cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34725/dvn/5slynz
title: Meteorological data for the study site

description: Meteorological data (rainfall and temperature) useful in relating growth and productivity to influence of weather variability
DOI: 10.34725/dvn/aqdwrf
title: Mekong Household Baseline

description: This study consists of sex-disaggregated data and other related materials generated as part of the Sentinel Landscapes Network household survey baseline in Mekong sentinel site in China, Thailand and Laos. A total of 1982 households were surveyed between October to November 2014, January 2015 and January to March 2016 from 60 villages namely: MengLuo, ZhuShiHe, Lantianxiazhai & Dahuangba, DingJiaZhai, YangJiaZhai, DaBa, Mengyeba & Chahe, ManSa, Dazhai & Xiaofang, LanTianShangZhai, DingJiaShangZhai, PaXiHe, ZhangJiaWan, JiuMiao, XinZhai, Manda, Manfa, Mangajian, Mankong, Manlao, Manleidai, ManLeine, Manlongdong, Manluanga, Manna, Mansaojing, Mantang, Manyingdai , Manyingne, Manyuan, Ban Hok, Ban Krueng Tai, Ban Kwak Nuea, Ban Lo, Ban Luang, Ban Muangchoom, Ban Nern Somboon, Ban San, Ban Sri Mongkol, Ban Srivilai, Ban Tha Chareon, Ban Thakham, Ban Tong, Ban Tonplong, Ban Yai Nuea, Sienglea, Phiahuanam, Phonsa At, Napa, Namet, Thamun, Pangthong, Huaylor, Nangoua, Mang, Namtouy, Yor, Lai Gnai, Muanghom, Nalai. The data consists of information on household demographics, migration, education, asset ownership, income sources, household food security, progress out of poverty, crop production and sales, livestock products, participation in credit markets, social networks, and natural resource use. In compliance with the CGIAR protocol on collecting sex-disaggregated data, approximately 50% of the respondents interviewed were women. Before downloading any of the files, particularly the data files, please download and read the ’Sentinel Landscapes Network Disclaimer and Terms of Use’ file.
DOI: 10.34725/dvn/fdr8xd
title: West Africa Village level Baseline

description: This study consists of village level baseline data and other related materials generated as part of the ‘Sentinel Landscapes’ initiative. The village level baseline data was collected using four survey protocols designed by the International Forest Resources and Institutions (IFRI). The data collected is used to understand the relationship between communities, local governance and forests. Four IFRI protocols were used for this purpose: (i) Forest Form (ii) Settlement Form (iii) Association Form and (iv) Product Form. The instruments facilitate the collection of political and institutional data at communal level for those communities that use those forests. A total of 46 villages were surveyed between October to December 2013 and march to May 2014 namely: Sakou, Nongsom, Temnaoré, Bogoname, Loaga, Badinogo2, Rambo Watinooma, Bam, Sam, Kouka, Dao, Diao, Gao, Kassolo, Cassou, Bongnounou, Pro, Tiabona, Yinga, Vrassan, Kou, Lerou, Lon, Lué, Pani, Passin, Mao-Nassira, Tékourou, Bechembelle(Bichenboi), Bugubelle, Funsi, Gbele, Hellebe(Halemboi), Jijen, Kojokpere, Kuroboi, Sakai, Welembelle, Dasima, Duang, Jolinyiri , Kulfuo, Nmanduanu, Sentie, Tarsaw, Vamboi.
DOI: 10.34725/dvn/g42gsd
title: Nicaragua - Honduras Household Baseline

description: This study consists of sex-disaggregated data and other related materials generated as part of the Sentinel Landscapes Network household survey baseline in Nicaragu-Honduras sentinel site in Nicaragua and Honduras. A total of 844 households were surveyed between September 2013 and February 2014 from 33 villages namely: Santa Cruz, Altamira, Sumubila, Nazareth, El Naranjal, Columbus, San Miguel, San Pablo, San Antonio De Upa, Rio Negro, Santa Ana, El Roblar, Los Limones, Verapaz, La Chimpinilla, Ilipo, Copen, Jardines De La Sierra, La Celia, Las Champas, Las Delicias, Cuyamel, Zapotales, El Venado, Limoncito, Las Guarumas, La Tambora, El Guancaste, La Bodega, La Gimerita, La Libertad, Los Laureles, Santa Marta. The data consists of information on household demographics, migration, education, asset ownership, income sources, household food security, progress out of poverty, crop production and sales, livestock products, participation in credit markets, social networks, and natural resource use. In compliance with the CGIAR protocol on collecting sex-disaggregated data, approximately 50% of the respondents interviewed were women. Before downloading any of the files, particularly the data files, please download and read the ’Sentinel Landscapes Network Disclaimer and Terms of Use’
DOI: 10.5281/zenodo.5100975
title: Dataset for: Using plant traits to understand the contribution of biodiversity effects to annual crop community productivity

description: Dataset for: Using plant traits to understand the contribution of biodiversity effects to annual crop community productivity
DOI: 10.5517/ccdc.csd.cc294dzv
title: CCDC 2119407: Experimental Crystal Structure Determination

description: Related Article: Xiangjie Chen, Yi An, Guangfen Du, Yujie Zhao, Lin He, Jixing Zhao, Shi-Wu Li|2022|J.Org.Chem.|87|5497|doi:10.1021/acs.joc.1c02757
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bt07f
title: CCDC 2168984: Experimental Crystal Structure Determination

description: Related Article: Yanlei He, Dan Luo, Vincent M. Lynch, Mehroz Ahmed, Jonathan L. Sessler, Xiaodong Chi|2022|Cell Press: Chem|9|93|doi:10.1016/j.chempr.2022.09.004
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2bwwmr
title: CCDC 2171755: Experimental Crystal Structure Determination

description: Related Article: Yanlei He, Dan Luo, Vincent M. Lynch, Mehroz Ahmed, Jonathan L. Sessler, Xiaodong Chi|2022|Cell Press: Chem|9|93|doi:10.1016/j.chempr.2022.09.004
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.57745/maiqkw
title: MilKey Data Collection Guide.pdf

description: :unav
DOI: 10.57745/s1sgis
title: MilKey Data Collection Guide_v1.1.pdf

description: :unav
DOI: 10.21227/97dm-r325
title: mag_data

description: Two-electrode straight open magnetic source (TSOMS) has been widely used on the magnetic minesweeper and magnetic decoy. Fast-forward modeling and obtaining the high-precision magnetic field in the air are the prerequisites for real-time inversion and positioning of the TSOMS. In this paper, we propose an algorithm to calculate the magnetic field of the two-electrode straight open magnetic source (MFTSOMS) by previous theoretical research. And a classical algorithm of electric dipole magnetic field is used to verify the correctness of our algorithm. Considering the relationship between the accuracy and efficiency of the calculation, the optimized number of subdivision units of n = 105 is determined. In this case, the time range of calculating one point is from 0.01 to 0.2 seconds, and the order of magnitude of the calculation accuracy is about 10-6. Furthermore, a scaling experiment has been performed, and the results show a great agreement with the simulation under the optimized number of subdivision units. Index Terms—Magnetic Field of the Two-electrode Straight Open Magnetic Source (MFTSOMS), calculation accuracy, calculation efficiency, scaling experiment.
DOI: 10.6073/pasta/77937d7de2a99d201f5e9f4dd8664eec
title: ASD02 Stream discharge measured at the flumes on watershed N04D at Konza Prairie

description: Stream discharge is measured on a catchment (N04D), with 4-year fire return interval and grazed by bison since 1992. Measurements are taken at 5 minute intervals at a triangular throated flume. The prairie streams are 3rd-order and are intermittent. Daily and stormflow discharge records are available.
DOI: 10.5281/zenodo.7544855
title: PMB Analogs

description: Raw dataset generated from the PDGA for the project: PMB analogs.
DOI: 10.5281/zenodo.7544854
title: PMB Analogs

description: Raw dataset generated from the PDGA for the project: PMB analogs.
DOI: 10.5281/zenodo.7544882
title: Bibliometric analysis of soft skills and serious games

description: Database of articles from WoS included under the topics "Soft Skills" and "Serious Games".
DOI: 10.5281/zenodo.7544881
title: Bibliometric analysis of soft skills and serious games

description: Database of articles from WoS included under the topics "Soft Skills" and "Serious Games".
DOI: 10.6084/m9.figshare.19780274
title: Distinct designer diamines promote mitophagy, and thereby enhance healthspan in <i>C. elegans</i> and protect human cells against oxidative damage

description: Impaired mitophagy is a primary pathogenic event underlying diverse aging-associated diseases such as Alzheimer and Parkinson diseases and sarcopenia. Therefore, augmentation of mitophagy, the process by which defective mitochondria are removed, then replaced by new ones, is an emerging strategy for preventing the evolvement of multiple morbidities in the elderly population. Based on the scaffold of spermidine (Spd), a known mitophagy-promoting agent, we designed and tested a family of structurally related compounds. A prototypic member, 1,8-diaminooctane (VL-004), exceeds Spd in its ability to induce mitophagy and protect against oxidative stress. VL-004 activity is mediated by canonical aging genes and promotes lifespan and healthspan in <i>C. elegans</i>. Moreover, it enhances mitophagy and protects against oxidative injury in rodent and human cells. Initial structural characterization suggests simple rules for the design of compounds with improved bioactivity, opening the way for a new generation of agents with a potential to promote healthy aging.
DOI: 10.6084/m9.figshare.19780274.v1
title: Distinct designer diamines promote mitophagy, and thereby enhance healthspan in <i>C. elegans</i> and protect human cells against oxidative damage

description: Impaired mitophagy is a primary pathogenic event underlying diverse aging-associated diseases such as Alzheimer and Parkinson diseases and sarcopenia. Therefore, augmentation of mitophagy, the process by which defective mitochondria are removed, then replaced by new ones, is an emerging strategy for preventing the evolvement of multiple morbidities in the elderly population. Based on the scaffold of spermidine (Spd), a known mitophagy-promoting agent, we designed and tested a family of structurally related compounds. A prototypic member, 1,8-diaminooctane (VL-004), exceeds Spd in its ability to induce mitophagy and protect against oxidative stress. VL-004 activity is mediated by canonical aging genes and promotes lifespan and healthspan in <i>C. elegans</i>. Moreover, it enhances mitophagy and protects against oxidative injury in rodent and human cells. Initial structural characterization suggests simple rules for the design of compounds with improved bioactivity, opening the way for a new generation of agents with a potential to promote healthy aging.
DOI: 10.6084/m9.figshare.19991021
title: Supplementary Materials for: The Chagas Antigen and Epitope Atlas

description: The Chagas Antigen and Epitope Atlas contains experimentally-derived information on the antigenicity of Trypanosoma cruzi peptides. Antigenicity was measured on peptide arrays assayed with serum samples from Chagas disease subjects and matched negative controls. <br> High-density peptide arrays with custom designs were to display peptides derived from two complete T. cruzi proteomes. <br> Sampling of subjects from diverse human populations complements the antigenicity information of proteins and peptides with seroprevalence information across the Americas.
DOI: 10.6084/m9.figshare.19991021.v1
title: Supplementary Materials for: The Chagas Antigen and Epitope Atlas

description: The Chagas Antigen and Epitope Atlas contains experimentally-derived information on the antigenicity of Trypanosoma cruzi peptides. Antigenicity was measured on peptide arrays assayed with serum samples from Chagas disease subjects and matched negative controls. <br> High-density peptide arrays with custom designs were to display peptides derived from two complete T. cruzi proteomes. <br> Sampling of subjects from diverse human populations complements the antigenicity information of proteins and peptides with seroprevalence information across the Americas.
DOI: 10.6084/m9.figshare.20361629
title: Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

description: Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of AD, and deep brain stimulation (DBS), a surgical strategy that modulates neuronal activity to treat neurological and psychiatric disorders, produced positive effects in AD patients. However, the molecular mechanisms underlying the protective role(s) of brain stimulation are still elusive. We have previously demonstrated that induction of synaptic activity exerts protection in mouse models of AD and frontotemporal dementia (FTD) by enhancing the macroautophagy/autophagy flux and lysosomal degradation of pathological MAPT/Tau. We now provide evidence that TFEB (transcription factor EB), a master regulator of lysosomal biogenesis and autophagy, is a key mediator of this cellular response. In cultured primary neurons from FTD-transgenic mice, synaptic stimulation inhibits MTORC1 signaling, thus promoting nuclear translocation of TFEB, which, in turn, induces clearance of MAPT/Tau oligomers. Conversely, synaptic activation fails to promote clearance of toxic MAPT/Tau in neurons expressing constitutively active RRAG GTPases, which sequester TFEB in the cytosol, or upon TFEB depletion. Activation of TFEB is also confirmed in vivo in DBS-stimulated AD mice. We also demonstrate that DBS reduces pathological MAPT/Tau and promotes neuroprotection in Parkinson disease patients with tauopathy. Altogether our findings indicate that stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau. This mechanism, underlying the protective effect of DBS, provides encouraging support for the use of synaptic stimulation as a therapeutic treatment against tauopathies.<b>Abbreviations:</b> 3xTg-AD: triple transgenic AD mice; AD: Alzheimer disease; CSA: cyclosporine A; DBS: deep brain stimulation; DIV: days <i>in vitro</i>; EC: entorhinal cortex; FTD: frontotemporal dementia; gLTP: glycine-induced long-term potentiation; GPi: internal segment of the globus pallidus; PD: Parkinson disease; STN: subthalamic nucleus; TFEB: transcription factor EB
DOI: 10.6084/m9.figshare.20361629.v1
title: Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

description: Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of AD, and deep brain stimulation (DBS), a surgical strategy that modulates neuronal activity to treat neurological and psychiatric disorders, produced positive effects in AD patients. However, the molecular mechanisms underlying the protective role(s) of brain stimulation are still elusive. We have previously demonstrated that induction of synaptic activity exerts protection in mouse models of AD and frontotemporal dementia (FTD) by enhancing the macroautophagy/autophagy flux and lysosomal degradation of pathological MAPT/Tau. We now provide evidence that TFEB (transcription factor EB), a master regulator of lysosomal biogenesis and autophagy, is a key mediator of this cellular response. In cultured primary neurons from FTD-transgenic mice, synaptic stimulation inhibits MTORC1 signaling, thus promoting nuclear translocation of TFEB, which, in turn, induces clearance of MAPT/Tau oligomers. Conversely, synaptic activation fails to promote clearance of toxic MAPT/Tau in neurons expressing constitutively active RRAG GTPases, which sequester TFEB in the cytosol, or upon TFEB depletion. Activation of TFEB is also confirmed in vivo in DBS-stimulated AD mice. We also demonstrate that DBS reduces pathological MAPT/Tau and promotes neuroprotection in Parkinson disease patients with tauopathy. Altogether our findings indicate that stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau. This mechanism, underlying the protective effect of DBS, provides encouraging support for the use of synaptic stimulation as a therapeutic treatment against tauopathies.<b>Abbreviations:</b> 3xTg-AD: triple transgenic AD mice; AD: Alzheimer disease; CSA: cyclosporine A; DBS: deep brain stimulation; DIV: days <i>in vitro</i>; EC: entorhinal cortex; FTD: frontotemporal dementia; gLTP: glycine-induced long-term potentiation; GPi: internal segment of the globus pallidus; PD: Parkinson disease; STN: subthalamic nucleus; TFEB: transcription factor EB
DOI: 10.6084/m9.figshare.20222886
title: Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

description: The accumulation of toxic protein aggregates in multiple neurodegenerative diseases is associated with defects in the macroautophagy/autophagy-lysosome pathway. The amelioration of disease phenotypes across multiple models of neurodegeneration can be achieved through modulating the master regulator of lysosome function, TFEB (transcription factor EB). Using a novel multi-parameter high-throughput screen for cytoplasmic:nuclear translocation of endogenous TFEB and the related transcription factor TFE3, we screened the Published Kinase Inhibitor Set 2 (PKIS2) library as proof of principle and to identify kinase regulators of TFEB and TFE3. Given that TFEB and TFE3 are responsive to cellular stress we have established assays for cellular toxicity and lysosomal function, critical to ensuring the identification of hit compounds with only positive effects on lysosome activity. In addition to AKT inhibitors which regulate TFEB localization, we identified a series of quinazoline-derivative compounds that induced TFEB and TFE3 translocation. A novel series of structurally-related analogs was developed, and several compounds induced TFEB and TFE3 translocation at higher potency than previously screened compounds. KINOME<i>scan</i> and cell-based KiNativ kinase profiling revealed high binding for the PRKD (protein kinase D) family of kinases, suggesting good selectivity for these compounds. We describe and utilize a cellular target-validation platform using CRISPRi knockdown and orthogonal PRKD inhibitors to demonstrate that the activity of these compounds is independent of PRKD inhibition. The more potent analogs induced subsequent upregulation of the CLEAR gene network and cleared pathological HTT protein in a cellular model of proteinopathy, demonstrating their potential to alleviate neurodegeneration-relevant phenotypes. <b>Abbreviations:</b> AD: Alzheimer disease; AK: adenylate kinase; CLEAR: coordinated lysosomal expression and regulation; CQ: chloroquine; HD: Huntington disease; PD: Parkinson disease; PKIS2: Published Kinase Inhibitor Set 2; PRKD: protein kinase D; TFEB: transcription factor EB.
DOI: 10.6084/m9.figshare.20222886.v1
title: Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

description: The accumulation of toxic protein aggregates in multiple neurodegenerative diseases is associated with defects in the macroautophagy/autophagy-lysosome pathway. The amelioration of disease phenotypes across multiple models of neurodegeneration can be achieved through modulating the master regulator of lysosome function, TFEB (transcription factor EB). Using a novel multi-parameter high-throughput screen for cytoplasmic:nuclear translocation of endogenous TFEB and the related transcription factor TFE3, we screened the Published Kinase Inhibitor Set 2 (PKIS2) library as proof of principle and to identify kinase regulators of TFEB and TFE3. Given that TFEB and TFE3 are responsive to cellular stress we have established assays for cellular toxicity and lysosomal function, critical to ensuring the identification of hit compounds with only positive effects on lysosome activity. In addition to AKT inhibitors which regulate TFEB localization, we identified a series of quinazoline-derivative compounds that induced TFEB and TFE3 translocation. A novel series of structurally-related analogs was developed, and several compounds induced TFEB and TFE3 translocation at higher potency than previously screened compounds. KINOME<i>scan</i> and cell-based KiNativ kinase profiling revealed high binding for the PRKD (protein kinase D) family of kinases, suggesting good selectivity for these compounds. We describe and utilize a cellular target-validation platform using CRISPRi knockdown and orthogonal PRKD inhibitors to demonstrate that the activity of these compounds is independent of PRKD inhibition. The more potent analogs induced subsequent upregulation of the CLEAR gene network and cleared pathological HTT protein in a cellular model of proteinopathy, demonstrating their potential to alleviate neurodegeneration-relevant phenotypes. <b>Abbreviations:</b> AD: Alzheimer disease; AK: adenylate kinase; CLEAR: coordinated lysosomal expression and regulation; CQ: chloroquine; HD: Huntington disease; PD: Parkinson disease; PKIS2: Published Kinase Inhibitor Set 2; PRKD: protein kinase D; TFEB: transcription factor EB.
DOI: 10.34740/kaggle/dsv/4864458
title: Mahanagar Yatayat Dataset
DOI: 10.6073/pasta/07a1f6dab0a38dd95807cb9213b1c3d2
title: ASD04 Stream discharge measured at the flumes on watershed N20B at Konza Prairie

description: Stream discharge is measured on a catchment (N20B), with 20-year fire return interval and grazed by bison since 1992. Measurements are taken at 5 minute intervals at a triangular throated flume. The prairie streams are 3rd-order and are intermittent. Daily and stormflow discharge records are available.
DOI: 10.6073/pasta/5ee258a7e1e906b81df480f8b39b735f
title: ASD05 Stream discharge measured at the flumes on watershed N01B at Konza Prairie

description: Stream discharge is measured on a catchment (N01B), with 1-year fire return interval and grazed by bison since 1992. Measurements are taken at 5 minute intervals at a triangular throated flume. The prairie streams are 3rd-order and are intermittent. Daily and stormflow discharge records are available.
DOI: 10.5519/qd.ikkgq1ra
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (12497 records)
DOI: 10.6073/pasta/c136851471a422e1447d866bd8cdd790
title: ASD06 Stream discharge measured at the flumes on watershed N02B at Konza Prairie

description: Stream discharge is measured on a catchment (N02B), with 2-year fire return interval and grazed by bison since 1992. Measurements are taken at 5 minute intervals at a triangular throated flume. The prairie streams are 3rd-order and are intermittent. Daily and stormflow discharge records are available.