cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25403/upresearchdata.25164680.v1
title: Management of mentoring relationship using capability framework

description: This dataset presents the themes for interviewing mentor teachers and preservice teachers regarding the management of mentoring relationships in Early Childhood schools (Pre-schools). The mentor teachers and preservice teachers reflected on their experiences in the mentoring relationship to understand their true experiences and feelings regarding the management of mentoring relationships, gaining insight into the capabilities and conversion factors involved in mentoring relationships. The dataset also includes the ages of the preservice teachers and the years of teaching experience of the mentor teachers, who remain anonymous.
DOI: 10.25403/upresearchdata.25164680.v2
title: Constraints and enablers in mentoring relationship between preservice and mentor teachers

description: This dataset presents the themes for interviewing mentor teachers and preservice teachers regarding the management of mentoring relationships in Early Childhood schools (Pre-schools). The mentor teachers and preservice teachers reflected on their experiences in the mentoring relationship to understand their true experiences and feelings regarding the management of mentoring relationships, gaining insight into the capabilities and conversion factors involved in mentoring relationships. The dataset also includes the ages of the preservice teachers and the years of teaching experience of the mentor teachers, who remain anonymous.
DOI: 10.6084/m9.figshare.21077783
title: Additional file 3 of Evaluating the national system for rare diseases in China from the point of drug access: progress and challenges

description: Additional file 3: Figure S3. The flow chart for orphan drug screening in the survey.
DOI: 10.6084/m9.figshare.21077774.v1
title: Additional file 16 of Evaluating the national system for rare diseases in China from the point of drug access: progress and challenges

description: Additional file 16: Table S16. Number of orphan drugs with better availability and affordability in each efficacy group.
DOI: 10.6084/m9.figshare.21077888
title: Additional file 5 of QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110β dependent autophagy

description: Additional file 5: Original data of QKI-interacted proteins analyzed by mass spectrometry
DOI: 10.6084/m9.figshare.21602251.v1
title: Additional file 1 of Glycoproteomics revealed novel N-glycosylation biomarkers for early diagnosis of lung adenocarcinoma cancers

description: Additional file 1: Table S1. MS identified information in this study.
DOI: 10.6084/m9.figshare.23700449.v1
title: Additional file 1 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

description: Additional file 1: Table S1.
DOI: 10.6084/m9.figshare.21077888.v1
title: Additional file 5 of QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110β dependent autophagy

description: Additional file 5: Original data of QKI-interacted proteins analyzed by mass spectrometry
DOI: 10.6084/m9.figshare.6401585.v1
title: Additional file 3: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S5. GO analysis of genes encoded by the CMRs at P7 and P60, and SMRs at the four developmental stages. (XLSX 128Â kb)
DOI: 10.6084/m9.figshare.6401612.v1
title: Additional file 4: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S6. GO and KEGG pathway enrichment analysis of the genes encoded by SMRs and CMRs compared between the m6A peaks at P7 and P60 that were identified by using MACS2 software. (XLSX 303Â kb)
DOI: 10.6084/m9.figshare.23700449
title: Additional file 1 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

description: Additional file 1: Table S1.
DOI: 10.6084/m9.figshare.6401633.v1
title: Additional file 5: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S7 List of the 839 RNAs with strong positive or negative correlation between their methylation levels and expression levels. (XLSX 82Â kb)
DOI: 10.6084/m9.figshare.6401561.v1
title: Additional file 1: of Thermal processing of food reduces gut microbiota diversity of the host and triggers adaptation of the microbiota: evidence from two vertebrates

description: This file contains all the supporting information that is associated with the manuscript, including four additional figure captions and legends and four additional tables. The figures are included in separate files and labeled Figures S1â S4. (ZIP 1360 kb)
DOI: 10.6084/m9.figshare.6401561
title: Additional file 1: of Thermal processing of food reduces gut microbiota diversity of the host and triggers adaptation of the microbiota: evidence from two vertebrates

description: This file contains all the supporting information that is associated with the manuscript, including four additional figure captions and legends and four additional tables. The figures are included in separate files and labeled Figures S1â S4. (ZIP 1360 kb)
DOI: 10.6084/m9.figshare.6401612
title: Additional file 4: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S6. GO and KEGG pathway enrichment analysis of the genes encoded by SMRs and CMRs compared between the m6A peaks at P7 and P60 that were identified by using MACS2 software. (XLSX 303Â kb)
DOI: 10.6084/m9.figshare.6401633
title: Additional file 5: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S7 List of the 839 RNAs with strong positive or negative correlation between their methylation levels and expression levels. (XLSX 82Â kb)
DOI: 10.6084/m9.figshare.6401651
title: Additional file 6: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S8 GO analysis of the genes with altered m6A levels between wild-type and Alkbh5-deficient mice exposed to hypobaric hypoxia. (XLSX 83Â kb)
DOI: 10.6084/m9.figshare.6401585
title: Additional file 3: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S5. GO analysis of genes encoded by the CMRs at P7 and P60, and SMRs at the four developmental stages. (XLSX 128Â kb)
DOI: 10.6084/m9.figshare.6401564
title: Additional file 2: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S4. GO analysis of genes containing m6A ON and OFF switches during mouse cerebellar development. (XLSX 564Â kb)
DOI: 10.6084/m9.figshare.6401564.v1
title: Additional file 2: of RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

description: Table S4. GO analysis of genes containing m6A ON and OFF switches during mouse cerebellar development. (XLSX 564Â kb)
DOI: 10.6084/m9.figshare.6401570
title: Additional file 2: of UMI-count modeling and differential expression analysis for single-cell RNA sequencing

description: This file includes all supplementary tables. (XLSX 1530 kb)
DOI: 10.6084/m9.figshare.6401570.v1
title: Additional file 2: of UMI-count modeling and differential expression analysis for single-cell RNA sequencing

description: This file includes all supplementary tables. (XLSX 1530 kb)
DOI: 10.6084/m9.figshare.7974449
title: Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy

description: Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in the placenta of preeclampsia patients at term. Even though this decrease was not mimicked in the placenta at the pre-term stage, miR-376c expression was decreased in the plasma of these patients as early as the second trimester. Plasma and placenta specimens were obtained from pregnant women having unifetal gestation undergoing perinatal care between January 2014 and December 2016 (n=49). Early trimester placentas were collected from patients undergoing terminated pregnancies through dilation and curettage procedure. Our results showed that in addition to miR-376c, miR-441 levels were decreased in the placenta of preeclampsia patients, and this decrease occurred both at pre-term and at term. This decrease is also mimicked in the plasma levels at both early and late weeks of pregnancy, highlighting that miR-441 levels can serve as a diagnostic marker of risk of preeclampsia in pregnant women. Overexpression of the miR-441, as well as miR-376c, promoted cell viability, migration, and invasion in the human immortalized cytotrophoblast cell line HTR8/SVneo, indicating that their decrease in pregnant women would result in anomalous apoptosis and functional imbalance resulting in premature abortion and other complications. MiR-441 level can thus potentially serve as diagnostic marker of preeclampsia in pregnant women.
DOI: 10.6084/m9.figshare.7974554.v1
title: Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells

description: Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various types of cancer. However, its role on human oral squamous cell carcinoma (OSCC) cells is still not well elucidated. In the present study, we investigated the effect of BITC on apoptosis and invasion of SCC9 cells, and its underlying mechanisms in vitro and in vivo. SCC9 cells were exposed to BITC (5 and 25 μM) for 24 and 48 h. Cell growth, apoptosis, invasion, and migration were detected in vitro by MTT, FITC-conjugated annexin V/propidium iodide staining followed by flow cytometry, Matrigel-coated semi-permeable modified Boyden, and wound-healing assay. S100A4, PUMA, and MMP-9 expressions were detected to investigate its mechanisms. Xenotransplantation experiments were used to investigate the role of BITC on tumor growth and lung metastasis. BITC inhibited cell viability and induced cell apoptosis in a dose- and time-dependent manner through upregulation of PUMA signals. BITC inhibited cell invasion and migration by downregulation of S100A4 dependent MMP-9 signals. The ip administration of BITC reduced tumor growth but not lung metastasis of SCC9 cells subcutaneously implanted in nude mice. BITC treatment activated pro-apoptotic PUMA and inhibited S100A4-dependent MMP-9 signals, resulting in the inhibition of cell growth and invasion in cultured and xenografted SCC9 cells. Thereby, BITC is a potential therapeutic approach for OSCC.
DOI: 10.6084/m9.figshare.7974560
title: Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk

description: The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Based on our selection criteria, 24 case-control studies were finally enrolled in this overall meta-analysis; a subgroup analysis by the factors ethnicity, control source, and RVO type was done. Through the association test of overall meta-analysis, we did not observe a significant difference between RVO cases and controls under the A vs G (allele) (z=1.49, P=0.137), A vs G (carrier) (z=1.42, P =0.155), GA vs GG (z=1.50, P=0.135), and GA+AA vs GG (z=1.50, P=0.135). Furthermore, we observed similar negative results in the association test of subgroup analysis (all P&gt;0.05). Heterogeneity, Begg's, and Egger's tests excluded the presence of high heterogeneity and publication bias. Statistically stable results were observed in the sensitivity analyses. Based on integrated analysis of the current evidence, Prothrombin gene G20210A polymorphism is likely unrelated to the risk of RVO.
DOI: 10.6084/m9.figshare.21606052.v1
title: clusterMLD: An Efficient Hierarchical Clustering Method for Multivariate Longitudinal Data

description: Longitudinal data clustering is challenging because the grouping has to account for the similarity of individual trajectories in the presence of sparse and irregular times of observation. This paper puts forward a hierarchical agglomerative clustering method based on a dissimilarity metric that quantifies the cost of merging two distinct groups of curves, which are depicted by <i>B</i>-splines for the repeatedly measured data. Extensive simulations show that the proposed method has superior performance in determining the number of clusters, classifying individuals into the correct clusters, and in computational efficiency. Importantly, the method is not only suitable for clustering multivariate longitudinal data with sparse and irregular measurements but also for intensely measured functional data. Towards this end, we provide an R package for the implementation of such analyses. To illustrate the use of the proposed clustering method, two large clinical data sets from real-world clinical studies are analyzed.
DOI: 10.6084/m9.figshare.7974560.v1
title: Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk

description: The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Based on our selection criteria, 24 case-control studies were finally enrolled in this overall meta-analysis; a subgroup analysis by the factors ethnicity, control source, and RVO type was done. Through the association test of overall meta-analysis, we did not observe a significant difference between RVO cases and controls under the A vs G (allele) (z=1.49, P=0.137), A vs G (carrier) (z=1.42, P =0.155), GA vs GG (z=1.50, P=0.135), and GA+AA vs GG (z=1.50, P=0.135). Furthermore, we observed similar negative results in the association test of subgroup analysis (all P&gt;0.05). Heterogeneity, Begg's, and Egger's tests excluded the presence of high heterogeneity and publication bias. Statistically stable results were observed in the sensitivity analyses. Based on integrated analysis of the current evidence, Prothrombin gene G20210A polymorphism is likely unrelated to the risk of RVO.
DOI: 10.6084/m9.figshare.4828924
title: Cutaneous applied nano-ZnO reduce the ability of hair follicle stem cells to differentiate

description: The ability of metal oxide nanoparticles to penetrate the skin has aroused a great deal of interest during the past decade due to concerns over the safety of topically applied sunscreens that contain physical UV-resistant metal particles, such as nano-Zinc oxide (nZnO). Previous studies demonstrate that metal oxide nanoparticles accumulate in skin furrows and hair follicles following topical application while little is known about the consequence of these nanoparticles on skin homeostasis. The current investigation tested the effects of nZnO (0.5 mg/day mouse) on hair follicle physiology. Topical application of Vaseline containing nZnO, bulk ZnO (bZnO), or ionized Zn to newborn mice vibrissa pad over a period of 7 consecutive days revealed that nZnO accumulated within hair follicles, and this induced the apoptosis of hair follicle stem cells (HFSCs). <i>In vitro</i> studies also indicated that nZnO exposure caused obvious DNA damage and induced apoptosis in HFSCs. Furthermore, it was found that nZnO exposure perturbed genes associated with HFSC apoptosis, cell communication, and differentiation. HFSCs transplantation assay demonstrated that the potential of HFSCs to differentiate was reduced. This investigation indicates a potential risk of topically applied ZnO nanoparticles on skin homeostasis.
DOI: 10.6084/m9.figshare.4828924.v1
title: Cutaneous applied nano-ZnO reduce the ability of hair follicle stem cells to differentiate

description: The ability of metal oxide nanoparticles to penetrate the skin has aroused a great deal of interest during the past decade due to concerns over the safety of topically applied sunscreens that contain physical UV-resistant metal particles, such as nano-Zinc oxide (nZnO). Previous studies demonstrate that metal oxide nanoparticles accumulate in skin furrows and hair follicles following topical application while little is known about the consequence of these nanoparticles on skin homeostasis. The current investigation tested the effects of nZnO (0.5 mg/day mouse) on hair follicle physiology. Topical application of Vaseline containing nZnO, bulk ZnO (bZnO), or ionized Zn to newborn mice vibrissa pad over a period of 7 consecutive days revealed that nZnO accumulated within hair follicles, and this induced the apoptosis of hair follicle stem cells (HFSCs). <i>In vitro</i> studies also indicated that nZnO exposure caused obvious DNA damage and induced apoptosis in HFSCs. Furthermore, it was found that nZnO exposure perturbed genes associated with HFSC apoptosis, cell communication, and differentiation. HFSCs transplantation assay demonstrated that the potential of HFSCs to differentiate was reduced. This investigation indicates a potential risk of topically applied ZnO nanoparticles on skin homeostasis.
DOI: 10.6084/m9.figshare.6401885.v1
title: Additional file 1: of Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy

description: Table S1. Summary of sequencing quality. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.6401939
title: Additional file 4: of Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy

description: Table S3. Summary of FPKM. (XLSX 20703 kb)
DOI: 10.6084/m9.figshare.23700524
title: Additional file 1 of Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

description: Supplementary File 1
DOI: 10.6084/m9.figshare.6401960.v1
title: Additional file 6: of Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy

description: Table S5. Summary of enrichment based on stricter light-inducible genes (213). (XLSX 32 kb)
DOI: 10.6084/m9.figshare.21606052
title: clusterMLD: An Efficient Hierarchical Clustering Method for Multivariate Longitudinal Data

description: Longitudinal data clustering is challenging because the grouping has to account for the similarity of individual trajectories in the presence of sparse and irregular times of observation. This paper puts forward a hierarchical agglomerative clustering method based on a dissimilarity metric that quantifies the cost of merging two distinct groups of curves, which are depicted by <i>B</i>-splines for the repeatedly measured data. Extensive simulations show that the proposed method has superior performance in determining the number of clusters, classifying individuals into the correct clusters, and in computational efficiency. Importantly, the method is not only suitable for clustering multivariate longitudinal data with sparse and irregular measurements but also for intensely measured functional data. Towards this end, we provide an R package for the implementation of such analyses. To illustrate the use of the proposed clustering method, two large clinical data sets from real-world clinical studies are analyzed.
DOI: 10.6084/m9.figshare.23700533.v1
title: Additional file 4 of Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

description: Supplementary File 4
DOI: 10.6084/m9.figshare.7974554
title: Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells

description: Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various types of cancer. However, its role on human oral squamous cell carcinoma (OSCC) cells is still not well elucidated. In the present study, we investigated the effect of BITC on apoptosis and invasion of SCC9 cells, and its underlying mechanisms in vitro and in vivo. SCC9 cells were exposed to BITC (5 and 25 μM) for 24 and 48 h. Cell growth, apoptosis, invasion, and migration were detected in vitro by MTT, FITC-conjugated annexin V/propidium iodide staining followed by flow cytometry, Matrigel-coated semi-permeable modified Boyden, and wound-healing assay. S100A4, PUMA, and MMP-9 expressions were detected to investigate its mechanisms. Xenotransplantation experiments were used to investigate the role of BITC on tumor growth and lung metastasis. BITC inhibited cell viability and induced cell apoptosis in a dose- and time-dependent manner through upregulation of PUMA signals. BITC inhibited cell invasion and migration by downregulation of S100A4 dependent MMP-9 signals. The ip administration of BITC reduced tumor growth but not lung metastasis of SCC9 cells subcutaneously implanted in nude mice. BITC treatment activated pro-apoptotic PUMA and inhibited S100A4-dependent MMP-9 signals, resulting in the inhibition of cell growth and invasion in cultured and xenografted SCC9 cells. Thereby, BITC is a potential therapeutic approach for OSCC.
DOI: 10.6084/m9.figshare.6401918
title: Additional file 3: of Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy

description: Table S2. Unigene annotation details. (XLSX 49576 kb)
DOI: 10.6084/m9.figshare.23700527
title: Additional file 2 of Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

description: Supplementary File 2
DOI: 10.6084/m9.figshare.6401960
title: Additional file 6: of Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy

description: Table S5. Summary of enrichment based on stricter light-inducible genes (213). (XLSX 32 kb)
DOI: 10.6084/m9.figshare.23700536.v1
title: Additional file 5 of Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

description: Supplementary File 5
DOI: 10.6084/m9.figshare.23700527.v1
title: Additional file 2 of Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

description: Supplementary File 2
DOI: 10.6084/m9.figshare.23700524.v1
title: Additional file 1 of Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

description: Supplementary File 1