cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19899434
title: State of conservation of a modernist curtain wall: statistical studies of factors that affect the natural aging pattern

description: Abstract External vertical sealing systems constituted of steel and glass curtain walls become vulnerable after years of use, and their functional and technological obsolescence increases the need for retrofitting. In the 1960s and 1970s, carbon steel curtain walls were widely used in modernist buildings, which justifies efforts to understand how their degradation occurs over the years. With the aim of outlining a method to investigate the state of conservation in order to understand the natural aging pattern of this type of system, this research study statistically evaluated the behaviour of the curtain wall of a 1960s building located on the Esplanade of the Ministries, in the Brazilian capital, Brasilia. To this end, a building inspection was carried out and the data fed the statistical analysis, where multiple comparisons between variables were used to understand how the façade aged and to discuss cause-effect relationships. The ground floor presented the worst state of conservation. The fixed frame typology was the most preserved. When the horizontal sections were evaluated, the results showed that the facade aged in a similar way, except for the corrosion state at the joining with the north facade, which presented the worst results.
DOI: 10.6084/m9.figshare.19899434.v1
title: State of conservation of a modernist curtain wall: statistical studies of factors that affect the natural aging pattern

description: Abstract External vertical sealing systems constituted of steel and glass curtain walls become vulnerable after years of use, and their functional and technological obsolescence increases the need for retrofitting. In the 1960s and 1970s, carbon steel curtain walls were widely used in modernist buildings, which justifies efforts to understand how their degradation occurs over the years. With the aim of outlining a method to investigate the state of conservation in order to understand the natural aging pattern of this type of system, this research study statistically evaluated the behaviour of the curtain wall of a 1960s building located on the Esplanade of the Ministries, in the Brazilian capital, Brasilia. To this end, a building inspection was carried out and the data fed the statistical analysis, where multiple comparisons between variables were used to understand how the façade aged and to discuss cause-effect relationships. The ground floor presented the worst state of conservation. The fixed frame typology was the most preserved. When the horizontal sections were evaluated, the results showed that the facade aged in a similar way, except for the corrosion state at the joining with the north facade, which presented the worst results.
DOI: 10.6084/m9.figshare.19899441
title: Bio-Exercise (BioEx) - A biocreative orofacial myofunctional therapy: preliminary cephalometric study and clinical application

description: ABSTRACT Objective: To introduce newly structured and developed orofacial myofunctional therapy (OFMFT) protocols named Bio-Exercise (BioEx), and evaluate the treatment effect of this method, using lateral cephalometric analysis on malocclusion with low tongue posture in young patients. Methods: A retrospective preliminary study was performed using orthodontic records from 28 patients (mean age of 8.41±1.45-year-old, 13 males, 15 females) treated with BioEx therapy using tongue elevators for 18.14±9.04 months (range: 6 to 37 months). Pretreatment (T0) and post-BioEx therapy (T1) lateral cephalograms were subsequently analyzed for tongue posture changes by linear, anteroposterior and vertical measurements. The data were analyzed by paired t-test, considering a 5% significance level. Results: The tongue length (TGL) and tongue height (TGH) increased statistically significant between T0 and T1. The decrease of the dorsum of the tongue perpendicular to the palatal plane (Td-PP value) was statistically significant. The increase of the tip of the tongue perpendicular to the pterygomaxillary vertical line (TT-PMV) was not statistically significant. Conclusions: These preliminary cephalometric results indicate that BioEx can be an effective OFMFT modality in increasing the tonicity of the tongue muscles to establish more normalized tongue position at rest.
DOI: 10.6084/m9.figshare.19899453
title: Anticoagulants and their effects on the hematological and biochemical parameters of yellow-spotted amazon river turtle

description: ABSTRACT: Knowledge of suitable methods and reagents for assessing the health condition of specimens of a given species is essential. The present study evaluated the efficacy of the heparin anticoagulants 5,000 I.U. mL-1, Na2EDTA, and K3EDTA on the blood parameters of yellow-spotted amazon river turtle Podocnemis unifilis, employing different solutions for red blood cells count. The use of the various anticoagulants evaluated after 10 hours of storage efficiently inhibited coagulation in blood samples from P. unifilis. An increased number of erythrocytes was observed with the use of K3EDTA 5% when compared with heparin. Statistically significant changes in the erythrocyte number were observed with the use of the different solutions. Solutions which featured sodium citrate and formaldehyde in their composition, allowed erythrocytes counting up to 120 hours after blood collection, without a change in values. The use of the heparin anticoagulants 5,000 I.U. mL-1, Na2EDTA 3%, Na2EDTA 5%, K3EDTA 3% was recommended in the hematological analysis of P. unifilis. Also recommended was the use of the formaldehyde-citrate solution containing 1.9 g of sodium citrate and 1.0 mL of formaldehyde (in 50 mL of distilled water) to perform red blood cells counts in yellow-spotted amazon river turtle.
DOI: 10.6084/m9.figshare.19899453.v1
title: Anticoagulants and their effects on the hematological and biochemical parameters of yellow-spotted amazon river turtle

description: ABSTRACT: Knowledge of suitable methods and reagents for assessing the health condition of specimens of a given species is essential. The present study evaluated the efficacy of the heparin anticoagulants 5,000 I.U. mL-1, Na2EDTA, and K3EDTA on the blood parameters of yellow-spotted amazon river turtle Podocnemis unifilis, employing different solutions for red blood cells count. The use of the various anticoagulants evaluated after 10 hours of storage efficiently inhibited coagulation in blood samples from P. unifilis. An increased number of erythrocytes was observed with the use of K3EDTA 5% when compared with heparin. Statistically significant changes in the erythrocyte number were observed with the use of the different solutions. Solutions which featured sodium citrate and formaldehyde in their composition, allowed erythrocytes counting up to 120 hours after blood collection, without a change in values. The use of the heparin anticoagulants 5,000 I.U. mL-1, Na2EDTA 3%, Na2EDTA 5%, K3EDTA 3% was recommended in the hematological analysis of P. unifilis. Also recommended was the use of the formaldehyde-citrate solution containing 1.9 g of sodium citrate and 1.0 mL of formaldehyde (in 50 mL of distilled water) to perform red blood cells counts in yellow-spotted amazon river turtle.
DOI: 10.6084/m9.figshare.19899458
title: Desirability Function in analytical method development for determination of glitazones and metabolites employing HF-LPME

description: Abstract Thiazolidinedione, often shortened to TZD or glitazone, helps lower insulin resistance, which is the underlying problem for many people with type 2 diabetes. The two most known glitazones are pioglitazone (PGZ), with the brand name medicine Actos®, and rosiglitazone (RSG), which is Avandia®. This study presented a multivariate optimization in the microextraction procedure employing Fractional Factorial Design (FFD) combined with Desirability Function (DF) to determine TZD and metabolites in biological samples. Microextraction requires several parameters to be optimized; however, most of them still use univariate optimization. Finding optimum conditions by simple response is relatively simple, but the problems, in case of microextractions, are often more complex when it has more responses. For example, changing one factor that promotes one response may suppress the effect of the others. Thus, this multivariate optimization was applied for two bioanalytical methods for determination of TZD and metabolites, one by HPLC and other by CE, both using Hollow Fiber Liquid-Phase Microextraction (HF-LPME). The results establish the optimal values and elucidate how the factors that affect HF-LPME procedure perform in extraction efficiency for TZDs. Additionally, this study demonstrates that DF can be an important tool to optimize microextraction procedures.
DOI: 10.6084/m9.figshare.19899458.v1
title: Desirability Function in analytical method development for determination of glitazones and metabolites employing HF-LPME

description: Abstract Thiazolidinedione, often shortened to TZD or glitazone, helps lower insulin resistance, which is the underlying problem for many people with type 2 diabetes. The two most known glitazones are pioglitazone (PGZ), with the brand name medicine Actos®, and rosiglitazone (RSG), which is Avandia®. This study presented a multivariate optimization in the microextraction procedure employing Fractional Factorial Design (FFD) combined with Desirability Function (DF) to determine TZD and metabolites in biological samples. Microextraction requires several parameters to be optimized; however, most of them still use univariate optimization. Finding optimum conditions by simple response is relatively simple, but the problems, in case of microextractions, are often more complex when it has more responses. For example, changing one factor that promotes one response may suppress the effect of the others. Thus, this multivariate optimization was applied for two bioanalytical methods for determination of TZD and metabolites, one by HPLC and other by CE, both using Hollow Fiber Liquid-Phase Microextraction (HF-LPME). The results establish the optimal values and elucidate how the factors that affect HF-LPME procedure perform in extraction efficiency for TZDs. Additionally, this study demonstrates that DF can be an important tool to optimize microextraction procedures.
DOI: 10.6084/m9.figshare.19899477.v1
title: INTRAVERTEBRAL EXPANDABLE IMPLANTS IN THORACOLUMBAR VERTEBRAL COMPRESSION FRACTURES

description: ABSTRACT Current scientific evidence enhances the importance of the anatomic restauration of vertebral bodies with compression fractures aiming, as with other human body joints, to obtain a biomechanic and functional spine as close as the one prior to the fracture as possible. We consider that anatomic reduction of these fractures is only completely possible using intravertebral expandable implants, restoring vertebral endplate morphology, and enabling a more adequate intervertebral disc healing. This enables avoiding disc and osteodegenerative changes to that vertebral segment and its adjacent levels, as well as the anterior overload of adjacent vertebral bodies in older adults - a consequence of post-traumatic vertebral flattening - thus minimizing the risk of adjacent vertebral fractures. The ability of vertebral body fracture reduction and height maintenance over time and its percutaneous transpedicular application make the intra-vertebral expandable implants a very attractive option for treating these fractures. The authors show the direct and indirect reduction concepts of vertebral fractures, review the biomechanics, characteristics and indications of intravertebral expandable implants and present a suggestion for updating the algorithm for the surgical treatment of vertebral compression fractures which includes the use of intravertebral expandable implants. Level of Evidence V, Expert Opinion.
DOI: 10.6084/m9.figshare.19899477
title: INTRAVERTEBRAL EXPANDABLE IMPLANTS IN THORACOLUMBAR VERTEBRAL COMPRESSION FRACTURES

description: ABSTRACT Current scientific evidence enhances the importance of the anatomic restauration of vertebral bodies with compression fractures aiming, as with other human body joints, to obtain a biomechanic and functional spine as close as the one prior to the fracture as possible. We consider that anatomic reduction of these fractures is only completely possible using intravertebral expandable implants, restoring vertebral endplate morphology, and enabling a more adequate intervertebral disc healing. This enables avoiding disc and osteodegenerative changes to that vertebral segment and its adjacent levels, as well as the anterior overload of adjacent vertebral bodies in older adults - a consequence of post-traumatic vertebral flattening - thus minimizing the risk of adjacent vertebral fractures. The ability of vertebral body fracture reduction and height maintenance over time and its percutaneous transpedicular application make the intra-vertebral expandable implants a very attractive option for treating these fractures. The authors show the direct and indirect reduction concepts of vertebral fractures, review the biomechanics, characteristics and indications of intravertebral expandable implants and present a suggestion for updating the algorithm for the surgical treatment of vertebral compression fractures which includes the use of intravertebral expandable implants. Level of Evidence V, Expert Opinion.
DOI: 10.6084/m9.figshare.19899479
title: CORRELATION BETWEEN QUALITY OF LIFE AND THE CLINICAL RESULTS OF PATIENTS WITH LEPROSY WITH DROP FOOT AFTER TENDON TRANSFER

description: ABSTRACT Objective: To evaluate the functional results of surgically correcting drop foot in patients with leprosy and compare their SALSA, Social Participation, and AOFAS score. Methods: Overall, 22 patients were subjected to posterior tibial tendon transfer via the subcutaneous route to the foot dorsum with an average follow-up of 56 months (min 12, max 70). In our sample, 15 of the enrolled patients were men and seven, women, aged between 20 and 73 years old who were operated on from January 2014 to December 2017. The Pearson’s correlation test (r) was used to measure the correlation among those scales. A p &lt; 0.05 was considered significant between the pre- and pos-operative AOFAS scale scores. Results: Pre-operative average AOFAS score was 59.6 (min 35, max 74) and 77.2 postoperative (min 36, max 97) (p &lt; 0.0001), postoperative Salsa and Social Participation scale, 30.6 and 22.5, respectively. Statistical analysis suggests a strong positive correlation between AOFAS and Salsa scales (r = −0.83) and AOFAS and social participation (r = −0.78). Average dorsiflexion was 5.4 degrees. Conclusion: The surgical correction of drop foot positively affects the quality of life and social participation of patients with leprosy. Level of Evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.19899479.v1
title: CORRELATION BETWEEN QUALITY OF LIFE AND THE CLINICAL RESULTS OF PATIENTS WITH LEPROSY WITH DROP FOOT AFTER TENDON TRANSFER

description: ABSTRACT Objective: To evaluate the functional results of surgically correcting drop foot in patients with leprosy and compare their SALSA, Social Participation, and AOFAS score. Methods: Overall, 22 patients were subjected to posterior tibial tendon transfer via the subcutaneous route to the foot dorsum with an average follow-up of 56 months (min 12, max 70). In our sample, 15 of the enrolled patients were men and seven, women, aged between 20 and 73 years old who were operated on from January 2014 to December 2017. The Pearson’s correlation test (r) was used to measure the correlation among those scales. A p &lt; 0.05 was considered significant between the pre- and pos-operative AOFAS scale scores. Results: Pre-operative average AOFAS score was 59.6 (min 35, max 74) and 77.2 postoperative (min 36, max 97) (p &lt; 0.0001), postoperative Salsa and Social Participation scale, 30.6 and 22.5, respectively. Statistical analysis suggests a strong positive correlation between AOFAS and Salsa scales (r = −0.83) and AOFAS and social participation (r = −0.78). Average dorsiflexion was 5.4 degrees. Conclusion: The surgical correction of drop foot positively affects the quality of life and social participation of patients with leprosy. Level of Evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.19899497
title: Testing spatial and environmental factors to explain body shape variation in the widespread Central American Blackbelt cichlid Vieja maculicauda (Teleostei: Cichlidae)

description: Abstract Body-shape variability may respond to the interaction between history and environment, particularly in species whose range includes known biogeographical barriers. Central America has traditionally been regarded to have functioned as a complete land-bridge connecting two continents since the Plio-Pleistocene and as an incomplete one since much earlier. This history has helped shape species diversification and distributions. Vieja maculicauda is a widely distributed cichlid, found throughout most of the Atlantic slope of Central America, across three of the four geological blocks that make up this region and whose borders are known dispersal barriers. We asked whether there is an effect of geologic blocks on body shape of V. maculicauda as determined by geometric morphometric assessment of 151 individuals from across its range. We asked how much variance in body shape is explained by environmental variables. We used a CVA and a MANCOVA to determine whether a relationship between body shape and geologic blocks exists. For testing body shape correlation against geographic and environmental variables, we used a Mantel test. Our results suggest that body shape in V. maculicauda can be segregated by geologic blocks, while the correlation results showed no strong correlation between our sets of variables.
DOI: 10.6084/m9.figshare.19899497.v1
title: Testing spatial and environmental factors to explain body shape variation in the widespread Central American Blackbelt cichlid Vieja maculicauda (Teleostei: Cichlidae)

description: Abstract Body-shape variability may respond to the interaction between history and environment, particularly in species whose range includes known biogeographical barriers. Central America has traditionally been regarded to have functioned as a complete land-bridge connecting two continents since the Plio-Pleistocene and as an incomplete one since much earlier. This history has helped shape species diversification and distributions. Vieja maculicauda is a widely distributed cichlid, found throughout most of the Atlantic slope of Central America, across three of the four geological blocks that make up this region and whose borders are known dispersal barriers. We asked whether there is an effect of geologic blocks on body shape of V. maculicauda as determined by geometric morphometric assessment of 151 individuals from across its range. We asked how much variance in body shape is explained by environmental variables. We used a CVA and a MANCOVA to determine whether a relationship between body shape and geologic blocks exists. For testing body shape correlation against geographic and environmental variables, we used a Mantel test. Our results suggest that body shape in V. maculicauda can be segregated by geologic blocks, while the correlation results showed no strong correlation between our sets of variables.
DOI: 10.6084/m9.figshare.19899495
title: Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

description: Abstract The objective of the present study was to develop time delayed chronotherapeutic formulation of Eplerenone (Ep) to provide rapid drug release after a pre-determined lag time for the treatment of early morning hypertension. Cyclodextrin complexation was used to prepare fast release Ep core tablets. The developed core tablets were then coated with different rate-controlling polymers using compression coating technique. The developed tablets were evaluated for hardness, friability, drug content and swelling index. The in-vitro drug release was carried out to study the effect of different coating materials on drug release and lag time. Tablets selected for stability study were those showing lag time of 5-7 hours followed by complete drug release; F2, F3, F7, F8, and F12. The in-vivo study was carried out on tablets with the highest t90 as compared to commercial tablets after being administered to healthy human volunteers where plasma Ep and urinary Na/K ratio were determined. Results suggested that this approach was able to provide delayed release Ep formulations that will be useful for patients with morning surge in blood pressure.
DOI: 10.6084/m9.figshare.19899495.v1
title: Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

description: Abstract The objective of the present study was to develop time delayed chronotherapeutic formulation of Eplerenone (Ep) to provide rapid drug release after a pre-determined lag time for the treatment of early morning hypertension. Cyclodextrin complexation was used to prepare fast release Ep core tablets. The developed core tablets were then coated with different rate-controlling polymers using compression coating technique. The developed tablets were evaluated for hardness, friability, drug content and swelling index. The in-vitro drug release was carried out to study the effect of different coating materials on drug release and lag time. Tablets selected for stability study were those showing lag time of 5-7 hours followed by complete drug release; F2, F3, F7, F8, and F12. The in-vivo study was carried out on tablets with the highest t90 as compared to commercial tablets after being administered to healthy human volunteers where plasma Ep and urinary Na/K ratio were determined. Results suggested that this approach was able to provide delayed release Ep formulations that will be useful for patients with morning surge in blood pressure.
DOI: 10.6084/m9.figshare.19899501
title: Different nitrogen levels on vegetative growth and yield of conilon coffee (Coffea canephora)

description: ABSTRACT: The determination of nitrogen in plants by techniques that allow a fast diagnosis, based on plant growth characteristics, can be a useful tool for the nutritional management of coffee plants. Thus, this study evaluated growth and yield characteristics of irrigated conilon coffee in response to different nitrogen levels, resulting in the determination of the minimum N levels required to achieve the maximum yield, here called critical levels. The experiment was carried out in Colatina, Espirito Santo, Brazil, on plantations of conilon coffee, clonal variety Emcapa 8111, genotype 02. Six nitrogen levels were applied (0, 110, 220, 440, 880 and 1320 kg N ha-1) and the response in growth and yield characteristics periodically evaluated. There was a positive effect of the increasing N levels on yield, in that the N levels that provided 95% of the maximum yield (137.4 bags ha-1 and 108.5 bags ha-1) in the 2012/2013 and 2013/2014 growing seasons, respectively, were 420.7 and 543.1 kg N ha-1. There was also a positive effect of N levels on the growth characteristics and nitrogen contents, indicating their use as tools for a rapid nutritional diagnosis, with a view to optimizing the nitrogen management in Conilon coffee.