cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.14499732
title: DataSet-Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177-Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model

description: Data published in 





PMID: 35499391

 PMCID: PMC9377759

 DOI: 10.1158/1535-7163.MCT-21-0791


Targeted radionuclide therapy (TRT) using probes labeled with Lutetium-177 (177Lu) represents a new and growing type of cancer therapy. We studied immunologic changes in response to TRT with 177Lu labeled anti-human CD20 camelid single domain antibodies (sdAb) in a B16-melanoma model transfected to express human CD20, the target antigen, and ovalbumin, a surrogate tumor antigen. High-dose TRT induced melanoma cell death, calreticulin exposure, and ATP-release in vitro. Melanoma-bearing mice received fractionated low and high-dose TRT via tumor targeting anti-human CD20 sdAbs, as opposed to control sdAbs. Tumor growth was delayed with both doses. Low- and high-dose TRT increased IL10 serum levels. Low-dose TRT also decreased CCL5 serum levels. At the tumor, high-dose TRT induced a type I IFN gene signature, while low-dose TRT induced a proinflammatory gene signature. Low- and high-dose TRT increased the percentage of PD-L1pos and PD-L2pos myeloid cells in tumors with a marked increase in alternatively activated macrophages after high-dose TRT. The percentage of tumor-infiltrating T cells was not changed, yet a modest increase in ovalbumin-specific CD8pos T-cells was observed after low-dose TRT. Contradictory, low and high-dose TRT decreased CD4pos Th1 cells in addition to double negative T cells. In conclusion, these data suggest that low and high-dose TRT induce distinct immunologic changes, which might serve as an anchoring point for combination therapy.
DOI: 10.5281/zenodo.14499733
title: DataSet-Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177-Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model

description: Data published in 





PMID: 35499391

 PMCID: PMC9377759

 DOI: 10.1158/1535-7163.MCT-21-0791


Targeted radionuclide therapy (TRT) using probes labeled with Lutetium-177 (177Lu) represents a new and growing type of cancer therapy. We studied immunologic changes in response to TRT with 177Lu labeled anti-human CD20 camelid single domain antibodies (sdAb) in a B16-melanoma model transfected to express human CD20, the target antigen, and ovalbumin, a surrogate tumor antigen. High-dose TRT induced melanoma cell death, calreticulin exposure, and ATP-release in vitro. Melanoma-bearing mice received fractionated low and high-dose TRT via tumor targeting anti-human CD20 sdAbs, as opposed to control sdAbs. Tumor growth was delayed with both doses. Low- and high-dose TRT increased IL10 serum levels. Low-dose TRT also decreased CCL5 serum levels. At the tumor, high-dose TRT induced a type I IFN gene signature, while low-dose TRT induced a proinflammatory gene signature. Low- and high-dose TRT increased the percentage of PD-L1pos and PD-L2pos myeloid cells in tumors with a marked increase in alternatively activated macrophages after high-dose TRT. The percentage of tumor-infiltrating T cells was not changed, yet a modest increase in ovalbumin-specific CD8pos T-cells was observed after low-dose TRT. Contradictory, low and high-dose TRT decreased CD4pos Th1 cells in addition to double negative T cells. In conclusion, these data suggest that low and high-dose TRT induce distinct immunologic changes, which might serve as an anchoring point for combination therapy.
DOI: 10.15468/dl.jfxwqv
title: Occurrence Download

description: A dataset containing 2223 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pergularia daemia",
 "Geometry POLYGON ((-17.62504 -34.81917, 51.13387 -34.81917, 51.13387 37.34999, -17.62504 37.34999, -17.62504 -34.81917))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2223 records from 85 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022676-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vp7cbk
title: Occurrence Download

description: A dataset containing 36515 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Taxon occurrence data for the FungalRoot database"
 ]
}

 The dataset includes 36515 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022678-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d57d53
title: Occurrence Download

description: A dataset containing 731 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is France",
 "Geometry POLYGON((-0.4363 45.05977,-0.41412 45.05977,-0.41412 45.07584,-0.4363 45.07584,-0.4363 45.05977))",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 731 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022679-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.23645/epacomptox.6328037
title: ToxCast Assay Description Documentation

description: This documentation for the ToxCast assay endpoints is in a format outlined by the OECD Guidance Document 211 (GD211) for describing non-guideline in vitro test methods and their interpretation. The intent of GD 211 is to harmonize non-guideline, in vitro method descriptions to allow assessment of the relevance of the test method for biological responses of interest and the quality of the data produced. These reports are a work in progress and will be iteratively updated as more information becomes available.Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25
DOI: 10.23645/epacomptox.6328037.v12
title: ToxCast Assay Description Documentation

description: This documentation for the ToxCast assay endpoints is in a format outlined by the OECD Guidance Document 211 (GD211) for describing non-guideline in vitro test methods and their interpretation. The intent of GD 211 is to harmonize non-guideline, in vitro method descriptions to allow assessment of the relevance of the test method for biological responses of interest and the quality of the data produced. These reports are a work in progress and will be iteratively updated as more information becomes available.Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25
DOI: 10.23645/epacomptox.6328037.v11
title: ToxCast Assay Description Documentation

description: This documentation for the ToxCast assay endpoints is in a format outlined by the OECD Guidance Document 211 (GD211) for describing non-guideline in vitro test methods and their interpretation. The intent of GD 211 is to harmonize non-guideline, in vitro method descriptions to allow assessment of the relevance of the test method for biological responses of interest and the quality of the data produced. These reports are a work in progress and will be iteratively updated as more information becomes available.Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25
DOI: 10.15468/dl.6njt2y
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Iberis amara",
 "Country is Ecuador",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022680-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7910/dvn/ry2cvr
title: Replication Data for: "Efficiency and Redistribution in Environmental Policy: An Equilibrium Analysis of Agricultural Supply Chains"

description: This is the replication package for “Efficiency and Redistribution in Environmental Policy: An Equilibrium Analysis of Agricultural Supply Chains,” accepted in 2025 by the Journal of Political Economy.
DOI: 10.5281/zenodo.17035679
title: Metadata, individual and co-assembled fecal esMAGdb, and biopsy contigs
title: Ulcerative colitis, cross-sectional,  AaUH

description: Data from High-resolution recovery of epithelial-associated gut microbiota using new alignment approach and an environment-specific reference database:

Metagenomic bacterial contig data from biopsies extracted using three different extraction kits (Section 3.2, dataset 1), the bacterial contig data from biopsies extracted using the Molzym kit (Section 3.3, dataset 2), the individually assembled and co-assembled metagenomic contig data from faecal samples – esMAGdb contigs (Section 3.4, dataset 3), and mixed-assembly MAGs from the faecal samples, including a HQ MAG filtered esMAGdb version (Section 3.4, dataset 4). The repository also includes the associated esMAGdb metadata and code examples of the bash script.

Data for the generated MAGs are available in the supplementary (Sup. Table 3).
DOI: 10.5281/zenodo.17035680
title: Metadata, individual and co-assembled fecal esMAGdb, and biopsy contigs
title: Ulcerative colitis, cross-sectional,  AaUH

description: Data from High-resolution recovery of epithelial-associated gut microbiota using new alignment approach and an environment-specific reference database:

Metagenomic bacterial contig data from biopsies extracted using three different extraction kits (Section 3.2, dataset 1), the bacterial contig data from biopsies extracted using the Molzym kit (Section 3.3, dataset 2), the individually assembled and co-assembled metagenomic contig data from faecal samples – esMAGdb contigs (Section 3.4, dataset 3), and mixed-assembly MAGs from the faecal samples, including a HQ MAG filtered esMAGdb version (Section 3.4, dataset 4). The repository also includes the associated esMAGdb metadata and code examples of the bash script.

Data for the generated MAGs are available in the supplementary (Sup. Table 3).
DOI: 10.15468/dl.jtnbw8
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Iberis amara",
 "Country is Estonia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 9 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022682-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r2cpd9
title: Occurrence Download

description: A dataset containing 4197 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Mimosa tenuiflora, Mimosa tenuiflora, Croton adamantinus)"
 ]
}

 The dataset includes 4197 records from 190 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022681-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5zc4k5
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Iberis amara",
 "Country is India",
 "HasCoordinate is true"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022683-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17046336
title: Gridded SSP-RCP land cover data from IMAGE 3.0.1

description: This dataset contains gridded global land cover data at 30 arcmin spatial resolution for various combinations of the shared socioeconomic pathways (SSPs) and representative concentration pathways (RCPs) from 1970 until 2100 in 5-year timesteps, based on the Integrated Model to Assess the Global Environment (IMAGE 3.0.1). 

The zip file ssp_nc_files.zip contains 15 subfolders, one for each SSP-RCP combination. Each subfolder contains two files with different land cover types:



GLANDCOVER_30MIN.nc



cropland (1)

pasture (2)

forest (3)

other natural land (4)

urban areas (5)



GLANDCOVERDETAIL_30MIN.nc



rainfed cropland (1)

irrigated cropland (2)

rainfed bio-energy crops (3)

irrigated bio-energy crops (4)

additional deforestation (5)

protected area (6)




For each grid cell, the global land cover data shows the grid cell share (0-1) allocated for a certain land cover type. The file GAREACELLNOWATER_30MIN.NC can be used in combination with the grid cell shares to calculate the land surface area (km2) per land cover type.

SSP scenarios from IMAGE are documented in: https://doi.org/10.1016/j.gloenvcha.2016.05.008

For any repository inquiries please contact: Jonathan Doelman (jonathan.doelman@pbl.nl) or Ruben Prütz (ruben.pruetz@pik-potsdam.de).

Python code to preprocess the land cover data can be found at: https://github.com/rubenpruetz/analysis-biodiversity-impact-per-removal 

KNMI Data Platform: https://dataplatform.knmi.nl/organization/pbl
DOI: 10.5281/zenodo.17046335
title: Gridded SSP-RCP land cover data from IMAGE 3.0.1

description: This dataset contains gridded global land cover data at 30 arcmin spatial resolution for various combinations of the shared socioeconomic pathways (SSPs) and representative concentration pathways (RCPs) from 1970 until 2100 in 5-year timesteps, based on the Integrated Model to Assess the Global Environment (IMAGE 3.0.1). 

The zip file ssp_nc_files.zip contains 15 subfolders, one for each SSP-RCP combination. Each subfolder contains two files with different land cover types:



GLANDCOVER_30MIN.nc



cropland (1)

pasture (2)

forest (3)

other natural land (4)

urban areas (5)



GLANDCOVERDETAIL_30MIN.nc



rainfed cropland (1)

irrigated cropland (2)

rainfed bio-energy crops (3)

irrigated bio-energy crops (4)

additional deforestation (5)

protected area (6)




For each grid cell, the global land cover data shows the grid cell share (0-1) allocated for a certain land cover type. The file GAREACELLNOWATER_30MIN.NC can be used in combination with the grid cell shares to calculate the land surface area (km2) per land cover type.

SSP scenarios from IMAGE are documented in: https://doi.org/10.1016/j.gloenvcha.2016.05.008

For any repository inquiries please contact: Jonathan Doelman (jonathan.doelman@pbl.nl) or Ruben Prütz (ruben.pruetz@pik-potsdam.de).

Python code to preprocess the land cover data can be found at: https://github.com/rubenpruetz/analysis-biodiversity-impact-per-removal 

KNMI Data Platform: https://dataplatform.knmi.nl/organization/pbl
DOI: 10.15468/dl.f25nfd
title: Occurrence Download

description: A dataset containing 5553568 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Asia",
 "Country is China",
 "OccurrenceStatus is Present",
 "Year 2000-2025"
 ]
}

 The dataset includes 5553568 records from 3724 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022652-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bezp2t
title: Occurrence Download

description: A dataset containing 16 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Iberolacerta galani Arribas, Carranza & Odierna, 2006"
 ]
}

 The dataset includes 16 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0130370-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.o11lwa
title: Occurrence Download

description: A dataset containing 125 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Year 2000-2018",
 "Geometry POLYGON((-99.19006 16.33118,-96.27869 15.54016,-94.37805 16.21033,-92.2467 14.60632,-91.79626 15.90271,-90.42297 16.02356,-90.41199 16.45203,-91.30188 17.21008,-91.01624 17.36389,-90.95032 17.8363,-89.02771 17.7594,-86.57776 21.38489,-90.14832 21.26404,-100.18433 23.17017,-99.19006 16.33118))",
 "HasCoordinate is true",
 "TaxonKey is Bothrops asper (Garman, 1883)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 125 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011449-180824113759888/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4d5h29
title: Occurrence Download

description: A dataset containing 8218619 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year 2016-2021"
 ]
}

 The dataset includes 8218619 records from 269 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0038710-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zs6tmj
title: Occurrence Download

description: A dataset containing 12006 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Empidonax flavescens Lawrence, 1865"
 ]
}

 The dataset includes 12006 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004254-180730143533302/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cmqc8g
title: Occurrence Download

description: A dataset containing 925 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Polygala fruticosa P.J.Bergius)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 925 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053371-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.oz63y7
title: Occurrence Download

description: A dataset containing 9195 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phaseolus lunatus L."
 ]
}

 The dataset includes 9195 records from 119 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011451-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8pkioj
title: Occurrence Download

description: A dataset containing 163201 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Marie-Victorin Herbarium (MT) - Plantes vasculaires"
 ]
}

 The dataset includes 163201 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015520-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sfhwww
title: Occurrence Download

description: A dataset containing 267 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Canistrocarpus cervicornis (Kütz.) J.C.De Paula & De Clerck",
 "Year 2000-2021"
 ]
}

 The dataset includes 267 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034176-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ciaf3x
title: Occurrence Download

description: A dataset containing 3536 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Apis florea Fabricius, 1787"
 ]
}

 The dataset includes 3536 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004254-190307172214381/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.94hks6
title: Occurrence Download

description: A dataset containing 206 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Mexico",
 "Country is Argentina",
 "Country is Brazil",
 "Country is Costa Rica"
 ]
 },
 "TaxonKey is Latrodectus geometricus C.L.Koch, 1841"
 ]
}

 The dataset includes 206 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011451-180730143533302/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x9wxnb
title: Occurrence Download

description: A dataset containing 210 species occurrences available in GBIF matching the query:
{
 "and" : [
 "InstitutionCode is FR",
 "TaxonKey is Xanthium L."
 ]
}

 The dataset includes 210 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0130407-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5zmgte
title: Occurrence Download

description: A dataset containing 113780 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "TaxonKey is Columbidae"
 ]
}

 The dataset includes 113780 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040687-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hnhv5w
title: Occurrence Download

description: A dataset containing 378 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "TaxonKey is Bactris gasipaes Kunth"
 ]
}

 The dataset includes 378 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034175-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bbg9ar
title: Occurrence Download

description: A dataset containing 556 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lemur catta Linnaeus, 1758"
 ]
}

 The dataset includes 556 records from 58 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011451-190813142620410/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.