cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4557823.v1
title: Supplementary Material for: Blood Outgrowth Endothelial Cells Reduce Hypoxia-Mediated Fibroblast to Myofibroblast Conversion by Decreasing Proangiogenic Cytokines

description: <b><i>Purpose:</i></b> Hypoxic conditions cause fibroblasts to differentiate into alpha smooth-muscle cell actin (α -SMA)-positive cells, i.e. myofibroblasts. This process is a hallmark of venous neointimal hyperplasia (VNH) associated with hemodialysis vascular access. The purpose of this study was to determine if blood outgrowth endothelial cells (BOEC) may reduce the conversion of fibroblasts into myofibroblasts under hypoxic conditions, and to determine the potential mechanisms involved. <b><i>Methods:</i></b> An experimental model was used, in which fibroblasts and BOEC were subjected to hypoxia under contact and transwell conditions to determine if BOEC reduce the conversion of fibroblasts into myofibroblasts under hypoxic conditions. Gene expression under different conditions was performed. In addition, functional assays including cell proliferation and migration were determined. <b><i>Results:</i></b> This study demonstrates that contact needs to occur between BOEC and fibroblasts for the reduction of the hypoxia-driven conversion of fibroblasts into α-SMA. This is associated with a decrease in several proangiogenic genes including vascular endothelial growth factor A, platelet-derived growth factor, fibroblast growth factor and matrix metalloproteinase 2 in fibroblasts in contact with BOEC when compared to fibroblasts alone. In addition, migration is significantly reduced while proliferation remains unchanged. <b><i>Conclusion:</i></b> This study helps provide rationale for using BOEC delivered to the adventitia of the outflow vein of hemodialysis vascular access to reduce VNH.
DOI: 10.6084/m9.figshare.4557805
title: Supplementary Material for: Unc93b1-Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection

description: Coxsackievirus strain B serotype 3 (CVB3)-induced<b> </b>myocarditis is an important human disease that causes permanent tissue damage and can lead to death from acute infection or long-term morbidity caused by chronic inflammation. The timing and magnitude of immune activation following CVB3 infection can mediate a positive host outcome or increase tissue pathology. To better elucidate the role of endosomal Toll-like receptor (TLR) signaling in acute CVB3 infection, we studied mice with a loss-of-function mutation, known as <i>Letr</i> for ‘loss of endosomal TLR response', in <i>Unc93b1</i>, which is a chaperone protein for TLR3, TLR7 and TLR9. Using <i>Unc93b1</i><sup><i>Letr/</i></sup><sup><i>Letr</i></sup> mice, we determined that <i>Unc93b1</i>-dependent TLR activation was essential for the survival of acute CVB3-induced myocarditis. We also determined that a lack of endosomal TLR signaling was associated with a higher viral load in target organs and that it increased inflammation, necrosis and fibrosis in cardiac tissue. Loss of <i>Unc93b1</i> function was also associated with increased cardiac expression of <i>Ifn-b</i> and markers of tissue injury and fibrosis including <i>Lcn2</i> and <i>Serpina3n</i> early after CVB3 infection. These observations establish a significant role for <i>Unc93b1</i> in the regulation of the host inflammatory response to CVB3 infection and also reveal potential mediators of host tissue damage that merit further investigation in acute viral myocarditis.
DOI: 10.6084/m9.figshare.4557814.v1
title: Supplementary Material for: Transcriptional Analysis of Host Responses to Marek's Disease Virus Infection in Chicken Thymus

description: Marek's disease virus (MDV) is a cell-associated alpha-herpesvirus that causes T-cell lymphomas and nervous disorders in chickens. Different from other lymphoid organs, the thymus is the site of T-cell maturation and differentiation. However, the transcriptional response to MDV infection in the chicken thymus is still not known. In this study, we performed genome-wide expression analysis in thymus tissues of RB1B-infected chickens at different time points to investigate the molecular mechanisms of MDV pathogenesis. The number of differentially expressed genes with 2-fold or higher changes (&gt;2) are as follows: 1,250 genes (7 dpi), 834 genes (14 dpi), 1,958 genes (21 dpi), and 2,306 genes (28 dpi). Gene ontology enrichment analysis revealed that the upregulated genes were involved in immune and inflammatory response at 7 dpi; angiogenesis, cytoskeleton organization, cell adhesion, and signal transduction showed different expressions at 21 and 28 dpi. The expression pattern of 18 randomly selected genes was confirmed by real-time RT-PCR. Several differently expressed host genes associated with tumor development are discussed. We identified the global host-gene expression pattern in the thymus of chickens that responded to MDV infection. The present data may provide groundwork for future investigation in the biology and pathogenesis of MDV.
DOI: 10.6084/m9.figshare.4557805.v1
title: Supplementary Material for: Unc93b1-Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection

description: Coxsackievirus strain B serotype 3 (CVB3)-induced<b> </b>myocarditis is an important human disease that causes permanent tissue damage and can lead to death from acute infection or long-term morbidity caused by chronic inflammation. The timing and magnitude of immune activation following CVB3 infection can mediate a positive host outcome or increase tissue pathology. To better elucidate the role of endosomal Toll-like receptor (TLR) signaling in acute CVB3 infection, we studied mice with a loss-of-function mutation, known as <i>Letr</i> for ‘loss of endosomal TLR response', in <i>Unc93b1</i>, which is a chaperone protein for TLR3, TLR7 and TLR9. Using <i>Unc93b1</i><sup><i>Letr/</i></sup><sup><i>Letr</i></sup> mice, we determined that <i>Unc93b1</i>-dependent TLR activation was essential for the survival of acute CVB3-induced myocarditis. We also determined that a lack of endosomal TLR signaling was associated with a higher viral load in target organs and that it increased inflammation, necrosis and fibrosis in cardiac tissue. Loss of <i>Unc93b1</i> function was also associated with increased cardiac expression of <i>Ifn-b</i> and markers of tissue injury and fibrosis including <i>Lcn2</i> and <i>Serpina3n</i> early after CVB3 infection. These observations establish a significant role for <i>Unc93b1</i> in the regulation of the host inflammatory response to CVB3 infection and also reveal potential mediators of host tissue damage that merit further investigation in acute viral myocarditis.
DOI: 10.6084/m9.figshare.4557751
title: Supplementary Material for: Assessment of Whole-Exome Sequence Data in Attempted Suicide within a Bipolar Disorder Cohort

description: Suicidal behavior is a complex and devastating phenotype with a heritable component that has not been fully explained by existing common genetic variant analyses. This study represents the first large-scale DNA sequencing project designed to assess the role of rare functional genetic variation in suicidal behavior risk. To accomplish this, whole-exome sequencing data for ∼19,000 genes were generated for 387 bipolar disorder subjects with a history of suicide attempt and 631 bipolar disorder subjects with no prior suicide attempts. Rare functional variants were assessed in all exome genes as well as pathways hypothesized to contribute to suicidal behavior risk. No result survived conservative Bonferroni correction, though many suggestive findings have arisen that merit additional attention. In addition, nominal support for past associations in genes, such as <i>BDNF</i>, and pathways, such as the hypothalamic-pituitary-adrenal axis, was also observed. Finally, a novel pathway was identified that is driven by aldehyde dehydrogenase genes. Ultimately, this investigation explores variation left largely untouched by existing efforts in suicidal behavior, providing a wealth of novel information to add to future investigations, such as meta-analyses.
DOI: 10.6084/m9.figshare.4557808.v2
title: Inspiratory muscle training is effective to reduce postoperative pulmonary complications and length of hospital stay: a systematic review and meta-analysis

description: <b>Purpose:</b> This study systematically review and meta-analyse the effectiveness of inspiratory muscle training (IMT) to reduce postoperative pulmonary complications (PPC) and length of hospital stay (LOS), both in the preoperative and/or postoperative periods of cardiac, pulmonary, and abdominal surgical patients. Sensitive analysis was performed to examine which patients benefit more from IMT according to methodological features (quality of studies and sample size), patient’s characteristics (pulmonary risk stratification, age, and body mass index), type of surgery, period of training, and training protocols (training doses and level of supervision). <b>Methods:</b> The literature search was made in the electronic databases PubMed®, EBSCO, Web of Science<sup>®</sup>, PEDro and Scopus<sup>®</sup>. Only randomized controlled trials were included. Data extraction, quality assessment and meta-analysis were performed. <b>Results:</b> We included 17 randomized controlled trials in the systematic review, of which, 12 were included for the PPC meta-analysis and 11 for the LOS meta-analysis. IMT significantly reduced the risk of PPC (Risk Ratio (RR) = 0.50, 95%CI: 0.39, 0.64, <i>I<sup>2 </sup></i>=<i><sup> </sup></i>0.0%), and a decrease in LOS (Mean Difference = −1.41, 95%CI: −2.07, −0.75, <i>I</i><sup>2</sup> = 0.0%). <b>Conclusion:</b> IMT is effective to reduce PPC and LOS in patients undergoing surgery.Implications for RehabilitationPhysiotherapy interventions with inspiratory muscle training (IMT) are effective to reduce postoperative pulmonary complications (PPC) and length of hospital stay (LOS) after major surgery, and should start preoperatively.Rehabilitation with IMT is beneficial at all ages and risk levels, but older and high-risk patients benefit more, as well as pulmonary surgery patients.IMT is more effective if it is supervised, and prescription target at least two-week period, sessions with more than 15 minutes, with imposed load increment, and adding other exercise modes. Physiotherapy interventions with inspiratory muscle training (IMT) are effective to reduce postoperative pulmonary complications (PPC) and length of hospital stay (LOS) after major surgery, and should start preoperatively. Rehabilitation with IMT is beneficial at all ages and risk levels, but older and high-risk patients benefit more, as well as pulmonary surgery patients. IMT is more effective if it is supervised, and prescription target at least two-week period, sessions with more than 15 minutes, with imposed load increment, and adding other exercise modes.
DOI: 10.6084/m9.figshare.4557808.v1
title: Inspiratory muscle training is effective to reduce postoperative pulmonary complications and length of hospital stay: a systematic review and meta-analysis

description: <b>Purpose:</b> This study systematically review and meta-analyse the effectiveness of inspiratory muscle training (IMT) to reduce postoperative pulmonary complications (PPC) and length of hospital stay (LOS), both in the preoperative and/or postoperative periods of cardiac, pulmonary, and abdominal surgical patients. Sensitive analysis was performed to examine which patients benefit more from IMT according to methodological features (quality of studies and sample size), patient’s characteristics (pulmonary risk stratification, age, and body mass index), type of surgery, period of training, and training protocols (training doses and level of supervision). <b>Methods:</b> The literature search was made in the electronic databases PubMed®, EBSCO, Web of Science<sup>®</sup>, PEDro and Scopus<sup>®</sup>. Only randomized controlled trials were included. Data extraction, quality assessment and meta-analysis were performed. <b>Results:</b> We included 17 randomized controlled trials in the systematic review, of which, 12 were included for the PPC meta-analysis and 11 for the LOS meta-analysis. IMT significantly reduced the risk of PPC (Risk Ratio (RR) = 0.50, 95%CI: 0.39, 0.64, <i>I<sup>2 </sup></i>=<i><sup> </sup></i>0.0%), and a decrease in LOS (Mean Difference = −1.41, 95%CI: −2.07, −0.75, <i>I</i><sup>2</sup> = 0.0%). <b>Conclusion:</b> IMT is effective to reduce PPC and LOS in patients undergoing surgery.Implications for RehabilitationPhysiotherapy interventions with inspiratory muscle training (IMT) are effective to reduce postoperative pulmonary complications (PPC) and length of hospital stay (LOS) after major surgery, and should start preoperatively.Rehabilitation with IMT is beneficial at all ages and risk levels, but older and high-risk patients benefit more, as well as pulmonary surgery patients.IMT is more effective if it is supervised, and prescription target at least two-week period, sessions with more than 15 minutes, with imposed load increment, and adding other exercise modes. Physiotherapy interventions with inspiratory muscle training (IMT) are effective to reduce postoperative pulmonary complications (PPC) and length of hospital stay (LOS) after major surgery, and should start preoperatively. Rehabilitation with IMT is beneficial at all ages and risk levels, but older and high-risk patients benefit more, as well as pulmonary surgery patients. IMT is more effective if it is supervised, and prescription target at least two-week period, sessions with more than 15 minutes, with imposed load increment, and adding other exercise modes.
DOI: 10.6084/m9.figshare.4557688
title: Table_S3.xlsx

description: Updated Table S3 in Karlsson et al. (2014) to include links to Genbank accessions for OTU sequences.<br>Karlsson, Ida; Friberg, Hanna; Steinberg, Christian; Persson, Paula (2014): Fungicide Effects on Fungal Community Composition in the Wheat Phyllosphere.<br>https://dx.doi.org/10.1371/journal.pone.0111786
DOI: 10.6084/m9.figshare.4557688.v1
title: Table_S3.xlsx

description: Updated Table S3 in Karlsson et al. (2014) to include links to Genbank accessions for OTU sequences.<br>Karlsson, Ida; Friberg, Hanna; Steinberg, Christian; Persson, Paula (2014): Fungicide Effects on Fungal Community Composition in the Wheat Phyllosphere.<br>https://dx.doi.org/10.1371/journal.pone.0111786
DOI: 10.6084/m9.figshare.4557676
title: File_Plos_One_Bedside_rounds_stata10.dta

description: Inpatient satisfaction scores with bedside and usual care
DOI: 10.6084/m9.figshare.4557685
title: Wound-healing patent data

description: Wound-healing patent data
DOI: 10.6084/m9.figshare.4557667
title: Wound-healing_patent_data

description: wound-healing patent data
DOI: 10.6084/m9.figshare.4557658
title: Radiation-associated angiosarcoma after breast cancer: Improved survival by excision of all irradiated skin and soft tissue of the thoracic wall? A report of six patients

description: Radiation-associated angiosarcoma after breast cancer: Improved survival by excision of all irradiated skin and soft tissue of the thoracic wall? A report of six patients
DOI: 10.6084/m9.figshare.4557658.v1
title: Radiation-associated angiosarcoma after breast cancer: Improved survival by excision of all irradiated skin and soft tissue of the thoracic wall? A report of six patients

description: Radiation-associated angiosarcoma after breast cancer: Improved survival by excision of all irradiated skin and soft tissue of the thoracic wall? A report of six patients
DOI: 10.6084/m9.figshare.4557616
title: Foreign aid, democracy, and gender quota laws

description: Why do so many developing countries have gender quota policies? This article argues that foreign aid programmes influence developing countries to adopt policies aimed at fulfilling international norms regarding gender equality. This relationship is driven by two causal mechanisms. On the one hand, countries may use gender quotas as a signal to improve their standing in the international hierarchy, possibly as an end unto itself, but more likely as a means towards ensuring future aid flows. On the other, countries may adopt gender quotas as a result of successful foreign aid interventions specifically designed to promote women’s empowerment. I test these two causal mechanisms using data on foreign aid commitments to 173 non-OECD countries from 1974 to 2012. The results suggest that while programmes targeting women’s empowerment may have some influence on quota adoption, developing countries dependent on United States foreign aid are also likely to use gender quotas as signalling devices rather than as a result of ongoing liberalization efforts.
DOI: 10.6084/m9.figshare.4557607
title: Fear of cancer recurrence and unmet needs among breast cancer survivors in the first five years. A cross-sectional study

description: <b>Background:</b> It is unclear to which degree the services available after end of treatment are sufficient to meet the needs of women treated for breast cancer. The aim of the present study was to identify patient-reported supportive care needs and the prevalence of fear of cancer recurrence (FCR) following end of treatment in women treated for breast cancer. <b>Material and methods:</b> Using a cross-sectional design, women treated for breast cancer (<i>n</i> = 155; mean age 63) completed questionnaires concerning supportive care needs and FCR. Inclusion criteria were: ≥18 years of age and treated for primary breast cancer at Aarhus University Hospital, Aarhus, Denmark and between three months and five years after diagnosis. Associations between demographic characteristics, clinical factors, side effects, late effects and the two dependent variables, unmet needs (examined with linear regression model), and FCR (examined with logistic regression model) were analyzed. <b>Results:</b> The response rate was 79.9%. Almost all (82.6%) women reported at least one unmet need (mean number 9.3; range 0–34). More than half (59.3%) of the unmet needs were rated as strong unmet needs. The most frequent unmet needs were concerned with doctors collaborate to coordinate care; the need for having ongoing dialog with healthcare providers to receive available local health care services, understandable and up-to-date information, to manage side effects and feeling reassured that the best medical care are given. Having unmet needs were associated with young age, short time since primary surgery, and having clinical FCR. FCR was reported by 54.8% of the women and was associated with short time since primary surgery, having chemotherapy, having unmet needs, and moderate to severe muscle and joint pain and fatigue. <b>Conclusions:</b> Breast cancer survivors experience substantial unmet needs years after end of treatment, particularly among younger women and women having clinical FCR. Furthermore, FCR is frequent among women, particularly when closer in time to primary surgery.
DOI: 10.6084/m9.figshare.4557592
title: Disrupted trophic interactions affect recruitment of boreal deciduous and coniferous trees in northern Europe

description: This depository contains two data sets:<br>1. Collected and analysed field data related to herbivore browsing, and2. The 50 x 50 km fishnet (GIS data) as applied in:Per Angelstam P., Manton M., Pedersen S. and M. Elbakidze 2017. Disrupted trophic interactions affect recruitment of boreal deciduous and coniferous trees in northern Europe. Ecological Applications xxPlease note, other data used in this publication can be sourced from the original data sources (see cited literature for more information).
DOI: 10.6084/m9.figshare.4557607.v1
title: Fear of cancer recurrence and unmet needs among breast cancer survivors in the first five years. A cross-sectional study

description: <b>Background:</b> It is unclear to which degree the services available after end of treatment are sufficient to meet the needs of women treated for breast cancer. The aim of the present study was to identify patient-reported supportive care needs and the prevalence of fear of cancer recurrence (FCR) following end of treatment in women treated for breast cancer. <b>Material and methods:</b> Using a cross-sectional design, women treated for breast cancer (<i>n</i> = 155; mean age 63) completed questionnaires concerning supportive care needs and FCR. Inclusion criteria were: ≥18 years of age and treated for primary breast cancer at Aarhus University Hospital, Aarhus, Denmark and between three months and five years after diagnosis. Associations between demographic characteristics, clinical factors, side effects, late effects and the two dependent variables, unmet needs (examined with linear regression model), and FCR (examined with logistic regression model) were analyzed. <b>Results:</b> The response rate was 79.9%. Almost all (82.6%) women reported at least one unmet need (mean number 9.3; range 0–34). More than half (59.3%) of the unmet needs were rated as strong unmet needs. The most frequent unmet needs were concerned with doctors collaborate to coordinate care; the need for having ongoing dialog with healthcare providers to receive available local health care services, understandable and up-to-date information, to manage side effects and feeling reassured that the best medical care are given. Having unmet needs were associated with young age, short time since primary surgery, and having clinical FCR. FCR was reported by 54.8% of the women and was associated with short time since primary surgery, having chemotherapy, having unmet needs, and moderate to severe muscle and joint pain and fatigue. <b>Conclusions:</b> Breast cancer survivors experience substantial unmet needs years after end of treatment, particularly among younger women and women having clinical FCR. Furthermore, FCR is frequent among women, particularly when closer in time to primary surgery.
DOI: 10.6084/m9.figshare.4557616.v1
title: Foreign aid, democracy, and gender quota laws

description: Why do so many developing countries have gender quota policies? This article argues that foreign aid programmes influence developing countries to adopt policies aimed at fulfilling international norms regarding gender equality. This relationship is driven by two causal mechanisms. On the one hand, countries may use gender quotas as a signal to improve their standing in the international hierarchy, possibly as an end unto itself, but more likely as a means towards ensuring future aid flows. On the other, countries may adopt gender quotas as a result of successful foreign aid interventions specifically designed to promote women’s empowerment. I test these two causal mechanisms using data on foreign aid commitments to 173 non-OECD countries from 1974 to 2012. The results suggest that while programmes targeting women’s empowerment may have some influence on quota adoption, developing countries dependent on United States foreign aid are also likely to use gender quotas as signalling devices rather than as a result of ongoing liberalization efforts.