cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12258086.v1
title: Additional file 1 of A meta-analytic evaluation of the correlation between event-free survival and overall survival in randomized controlled trials of newly diagnosed Ewing sarcoma

description: Additional file 1: Table S1. Detailed description of RCTs. RCT, randomized controlled trial; ITT, intention-to-treat; OS, overall survival; EFS, event-free survival; DFS, disease-free survival; VCR, vincristine; ActD, actinomycin D; CPA, cyclophosphamide; ADM (DOX), doxorubicin; IFM, ifosfamide; ETP, etoposide; VAC, VCR + ActD+CPA; VACA, VCR + ActD+CPA + ADM; VAIA, VCR + ActD+IFM + ADM; VAI, VCR + ActD+IFM; VDC, VCR + doxorubicin+CPA; IE, IFM + ETP; EVAIA, ETP + VCR + ActD+IFM + ADM.
DOI: 10.6084/m9.figshare.12258020
title: Additional file 1 of In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

description: Additional file 1.
DOI: 10.6084/m9.figshare.12258026
title: Additional file 2 of In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

description: Additional file 2.
DOI: 10.6084/m9.figshare.12258026.v1
title: Additional file 2 of In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

description: Additional file 2.
DOI: 10.6084/m9.figshare.12258020.v1
title: Additional file 1 of In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

description: Additional file 1.
DOI: 10.6084/m9.figshare.12257954
title: Additional file 3 of Feasibility of using an led-probe in third-space endoscopy: a clinical study

description: Additional file 3. POEM files. This is the POEM files from our cohort of patients with POEM that underwent to LP procedure.
DOI: 10.6084/m9.figshare.12257957
title: Additional file 4 of Feasibility of using an led-probe in third-space endoscopy: a clinical study

description: Additional file 4. G-POEM files. This is the G-POEM files from our cohort of patients with G-POEM that underwent to LP procedure.
DOI: 10.6084/m9.figshare.12257957.v1
title: Additional file 4 of Feasibility of using an led-probe in third-space endoscopy: a clinical study

description: Additional file 4. G-POEM files. This is the G-POEM files from our cohort of patients with G-POEM that underwent to LP procedure.
DOI: 10.6084/m9.figshare.12257954.v1
title: Additional file 3 of Feasibility of using an led-probe in third-space endoscopy: a clinical study

description: Additional file 3. POEM files. This is the POEM files from our cohort of patients with POEM that underwent to LP procedure.
DOI: 10.17632/ny945rfh3t.1
title: Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP): two morphological variants can be outlined. Supplemental table.

description: Online supplemental table. References of the literature review’s cases.
DOI: 10.6084/m9.figshare.12257639
title: Supplementary Material for: Sequential Systemic Treatment in Advanced Hepatocellular Carcinoma Is Able to Prolong Median Survival to More than 3 Years in a Selected Real-World Cohort

description: <b><i>Introduction:</i></b> The number of efficacious systemic agents for advanced hepatocellular carcinoma (HCC) has rapidly increased over the past 3 years. However, guidance for optimal sequential systemic treatment in patients with advanced disease and experience with outcome and safety profiles are lacking. <b><i>Objective:</i></b> We aimed to assess efficacy and tolerability of sequential systemic therapy of advanced HCC. <b><i>Methods:</i></b> Our single-center study prospectively followed 14 patients who received multiple, sequential systemic therapies after progression or intolerance to sorafenib. Endpoints were overall and progression-free survival (OS, PFS), objective response rate (ORR), and treatment-emergent adverse events (TEAE). <b><i>Results:</i></b> Patients had well-compensated liver function and good performance status at start of each systemic therapy. Agents included sorafenib (<i>n</i> = 14), regorafenib (<i>n</i> = 10), immunotherapy with nivolumab or pembrolizumab (<i>n</i> = 10), lenvatinib (<i>n</i> = 3), ramucirumab (<i>n</i> = 2), and others, with a median of 3 lines of systemic therapy per patient. Median OS was 37.4 months from initiation of first-line therapy with sorafenib. PFS and ORR for sorafenib, regorafenib, and immunotherapy were 6.6, 5.3, and 6.6 months, and 15.4, 11.1, and 22.2%, respectively. TEAE were frequent (46–80%), but mostly manageable during tyrosine kinase inhibitor therapy and without the need for termination in most patients. However, TEAE due to immunotherapy (60%) led to cessation of treatment in 40% of the patients. <b><i>Conclusions:</i></b> Sequential systemic therapy is able to prolong median OS in selected patients with advanced HCC to more than 3 years. TEAE are frequent, but manageable, and the quality of adverse events depends on the respective agent. Further investigation of potential predictive biomarkers for treatment allocation is needed.
DOI: 10.6084/m9.figshare.12257639.v1
title: Supplementary Material for: Sequential Systemic Treatment in Advanced Hepatocellular Carcinoma Is Able to Prolong Median Survival to More than 3 Years in a Selected Real-World Cohort

description: <b><i>Introduction:</i></b> The number of efficacious systemic agents for advanced hepatocellular carcinoma (HCC) has rapidly increased over the past 3 years. However, guidance for optimal sequential systemic treatment in patients with advanced disease and experience with outcome and safety profiles are lacking. <b><i>Objective:</i></b> We aimed to assess efficacy and tolerability of sequential systemic therapy of advanced HCC. <b><i>Methods:</i></b> Our single-center study prospectively followed 14 patients who received multiple, sequential systemic therapies after progression or intolerance to sorafenib. Endpoints were overall and progression-free survival (OS, PFS), objective response rate (ORR), and treatment-emergent adverse events (TEAE). <b><i>Results:</i></b> Patients had well-compensated liver function and good performance status at start of each systemic therapy. Agents included sorafenib (<i>n</i> = 14), regorafenib (<i>n</i> = 10), immunotherapy with nivolumab or pembrolizumab (<i>n</i> = 10), lenvatinib (<i>n</i> = 3), ramucirumab (<i>n</i> = 2), and others, with a median of 3 lines of systemic therapy per patient. Median OS was 37.4 months from initiation of first-line therapy with sorafenib. PFS and ORR for sorafenib, regorafenib, and immunotherapy were 6.6, 5.3, and 6.6 months, and 15.4, 11.1, and 22.2%, respectively. TEAE were frequent (46–80%), but mostly manageable during tyrosine kinase inhibitor therapy and without the need for termination in most patients. However, TEAE due to immunotherapy (60%) led to cessation of treatment in 40% of the patients. <b><i>Conclusions:</i></b> Sequential systemic therapy is able to prolong median OS in selected patients with advanced HCC to more than 3 years. TEAE are frequent, but manageable, and the quality of adverse events depends on the respective agent. Further investigation of potential predictive biomarkers for treatment allocation is needed.
DOI: 10.6084/m9.figshare.12254957
title: The Impact of Churn on Client Value in Health Insurance, Evaluation Using a Random Forest Under Various Censoring Mechanisms

description: <b><i>Abstract–</i>In the insurance broker market, commissions received by brokers are closely related to so-called “customer value”: the longer a policyholder keeps their contract, the more profit there is for the company and therefore the broker. Hence, predicting the time at which a potential policyholder will surrender their contract is essential to optimize a commercial process and define a prospect scoring. In this article, we propose a weighted random forest model to address this problem. Our model is designed to compensate for the impact of random censoring. We investigate different types of assumptions on the censoring, studying both the cases where it is independent or not from the covariates. We compare our approach with other standard methods which apply in our setting, using simulated and real data analysis. We show that our approach is very competitive in terms of quadratic error in addressing the given problem. Supplementary materials for this article are available online.</b>
DOI: 10.6084/m9.figshare.12254957.v2
title: The Impact of Churn on Client Value in Health Insurance, Evaluation Using a Random Forest Under Various Censoring Mechanisms

description: <b><i>Abstract–</i>In the insurance broker market, commissions received by brokers are closely related to so-called “customer value”: the longer a policyholder keeps their contract, the more profit there is for the company and therefore the broker. Hence, predicting the time at which a potential policyholder will surrender their contract is essential to optimize a commercial process and define a prospect scoring. In this article, we propose a weighted random forest model to address this problem. Our model is designed to compensate for the impact of random censoring. We investigate different types of assumptions on the censoring, studying both the cases where it is independent or not from the covariates. We compare our approach with other standard methods which apply in our setting, using simulated and real data analysis. We show that our approach is very competitive in terms of quadratic error in addressing the given problem. Supplementary materials for this article are available online.</b>
DOI: 10.6084/m9.figshare.12254522
title: The information score as a measure of oral discourse comprehension in the early school years

description: <i>Purpose</i>: Oral discourse comprehension is a fundamental skill that is predictive of future reading comprehension. The ability to identify important semantic propositions, in a narrative text, and their attachment to a mental model is an essential component of discourse comprehension. This study aimed to pilot a measure of free-recall in a narrative retell across three age groups to explore development. A secondary aim compared measures of free-recall and cued-recall. <i>Method</i>: One hundred and thirty-two (132) typically developing children aged 4–7 years provided a retell of the Squirrel Story narrative and completed the Narrative Comprehension Assessment (NCA). The Squirrel Story Information Score (SSIS) was used as a novel measure of free-recall calculated from the narrative retells. The NCA, which involves literal and inferential comprehension questions, was used as a measure of cued-recall. Scoring reliability was calculated to ensure test–retest validity. <i>Result</i>: Correlation analysis found excellent reliability of the SSIS measure. The difference between 4 and 5 year olds, and 5 and 6 year olds, was significant, with a large effect size. The difference between the 5 and 6 year olds was not significant. A large positive correlation was found between the measures of SSIS and NCA. <i>Conclusion</i>: The measure of SSIS proved sensitive to developmental progression, with a positive relationship found between the measures of free-recall and cued-recall. Variability between the measures highlights the need to consider both measures to ensure an accurate representation of discourse comprehension skills.
DOI: 10.6084/m9.figshare.12254522.v2
title: The information score as a measure of oral discourse comprehension in the early school years

description: <i>Purpose</i>: Oral discourse comprehension is a fundamental skill that is predictive of future reading comprehension. The ability to identify important semantic propositions, in a narrative text, and their attachment to a mental model is an essential component of discourse comprehension. This study aimed to pilot a measure of free-recall in a narrative retell across three age groups to explore development. A secondary aim compared measures of free-recall and cued-recall. <i>Method</i>: One hundred and thirty-two (132) typically developing children aged 4–7 years provided a retell of the Squirrel Story narrative and completed the Narrative Comprehension Assessment (NCA). The Squirrel Story Information Score (SSIS) was used as a novel measure of free-recall calculated from the narrative retells. The NCA, which involves literal and inferential comprehension questions, was used as a measure of cued-recall. Scoring reliability was calculated to ensure test–retest validity. <i>Result</i>: Correlation analysis found excellent reliability of the SSIS measure. The difference between 4 and 5 year olds, and 5 and 6 year olds, was significant, with a large effect size. The difference between the 5 and 6 year olds was not significant. A large positive correlation was found between the measures of SSIS and NCA. <i>Conclusion</i>: The measure of SSIS proved sensitive to developmental progression, with a positive relationship found between the measures of free-recall and cued-recall. Variability between the measures highlights the need to consider both measures to ensure an accurate representation of discourse comprehension skills.
DOI: 10.6084/m9.figshare.12254522.v1
title: The information score as a measure of oral discourse comprehension in the early school years

description: <i>Purpose</i>: Oral discourse comprehension is a fundamental skill that is predictive of future reading comprehension. The ability to identify important semantic propositions, in a narrative text, and their attachment to a mental model is an essential component of discourse comprehension. This study aimed to pilot a measure of free-recall in a narrative retell across three age groups to explore development. A secondary aim compared measures of free-recall and cued-recall. <i>Method</i>: One hundred and thirty-two (132) typically developing children aged 4–7 years provided a retell of the Squirrel Story narrative and completed the Narrative Comprehension Assessment (NCA). The Squirrel Story Information Score (SSIS) was used as a novel measure of free-recall calculated from the narrative retells. The NCA, which involves literal and inferential comprehension questions, was used as a measure of cued-recall. Scoring reliability was calculated to ensure test–retest validity. <i>Result</i>: Correlation analysis found excellent reliability of the SSIS measure. The difference between 4 and 5 year olds, and 5 and 6 year olds, was significant, with a large effect size. The difference between the 5 and 6 year olds was not significant. A large positive correlation was found between the measures of SSIS and NCA. <i>Conclusion</i>: The measure of SSIS proved sensitive to developmental progression, with a positive relationship found between the measures of free-recall and cued-recall. Variability between the measures highlights the need to consider both measures to ensure an accurate representation of discourse comprehension skills.
DOI: 10.6084/m9.figshare.12254486
title: Table S1 from After the bite: bacterial transmission from grey seals (<i>Halichoerus grypus</i>) to harbour porpoises (<i>Phocoena phocoena</i>)

description: Total OTU diversity and OTU counts of all samples included in this study.
DOI: 10.6084/m9.figshare.12254480
title: Supplementary material from After the bite: bacterial transmission from grey seals (<i>Halichoerus grypus</i>) to harbour porpoises (<i>Phocoena phocoena</i>)

description: The complete set of R commands used to process the microbiome data.
DOI: 10.6084/m9.figshare.12254486.v1
title: Table S1 from After the bite: bacterial transmission from grey seals (<i>Halichoerus grypus</i>) to harbour porpoises (<i>Phocoena phocoena</i>)

description: Total OTU diversity and OTU counts of all samples included in this study.
DOI: 10.6084/m9.figshare.12254480.v1
title: Supplementary material from After the bite: bacterial transmission from grey seals (<i>Halichoerus grypus</i>) to harbour porpoises (<i>Phocoena phocoena</i>)

description: The complete set of R commands used to process the microbiome data.
DOI: 10.6084/m9.figshare.12254459
title: Table S1a-b. Specimen list+Genbank no from Sponge symbiosis is facilitated by adaptive evolution of larval sensory and attachment structures in barnacles

description: Symbiotic relations and range of host usage are prominent in coral reefs and crucial to the stability of such systems. In order to explain how symbiotic relations are established and evolve, we used sponge-associated barnacles to ask (1) Does larval settlement on sponge hosts require novel adaptations facilitating symbiosis? (2) How do larvae settle and start life on their hosts? (3) How has this remarkable symbiotic lifestyle involving many barnacle species evolved? We found that the larvae (cyprids) of sponge-associated barnacles show a remarkably high level of interspecific variation compared with other barnacles. We document that variation in larval attachment devices are specifically related to properties of the surface on which they attach and metamorphose. Mapping of the larval and sponge surface features onto a molecular-based phylogeny showed that sponge symbiosis evolved separately at least three times within barnacles, with the same adaptive features being found in all larvae irrespective of phylogenetic relatedness. Furthermore, the metamorphosis of two species proceeded very differently, with one species remaining superficially on the host and developing a set of white calcareous structures, the other embedding itself into the live host tissue almost immediately after settlement. We argue that such a high degree of evolutionary flexibility of barnacle larvae played an important role in the successful evolution of complex symbiotic relationships in both coral reefs and other marine systems.
DOI: 10.6084/m9.figshare.12254459.v1
title: Table S1a-b. Specimen list+Genbank no from Sponge symbiosis is facilitated by adaptive evolution of larval sensory and attachment structures in barnacles

description: Symbiotic relations and range of host usage are prominent in coral reefs and crucial to the stability of such systems. In order to explain how symbiotic relations are established and evolve, we used sponge-associated barnacles to ask (1) Does larval settlement on sponge hosts require novel adaptations facilitating symbiosis? (2) How do larvae settle and start life on their hosts? (3) How has this remarkable symbiotic lifestyle involving many barnacle species evolved? We found that the larvae (cyprids) of sponge-associated barnacles show a remarkably high level of interspecific variation compared with other barnacles. We document that variation in larval attachment devices are specifically related to properties of the surface on which they attach and metamorphose. Mapping of the larval and sponge surface features onto a molecular-based phylogeny showed that sponge symbiosis evolved separately at least three times within barnacles, with the same adaptive features being found in all larvae irrespective of phylogenetic relatedness. Furthermore, the metamorphosis of two species proceeded very differently, with one species remaining superficially on the host and developing a set of white calcareous structures, the other embedding itself into the live host tissue almost immediately after settlement. We argue that such a high degree of evolutionary flexibility of barnacle larvae played an important role in the successful evolution of complex symbiotic relationships in both coral reefs and other marine systems.
DOI: 10.6084/m9.figshare.12254444
title: File S1. SeqAilgment from Sponge symbiosis is facilitated by adaptive evolution of larval sensory and attachment structures in barnacles

description: Symbiotic relations and range of host usage are prominent in coral reefs and crucial to the stability of such systems. In order to explain how symbiotic relations are established and evolve, we used sponge-associated barnacles to ask (1) Does larval settlement on sponge hosts require novel adaptations facilitating symbiosis? (2) How do larvae settle and start life on their hosts? (3) How has this remarkable symbiotic lifestyle involving many barnacle species evolved? We found that the larvae (cyprids) of sponge-associated barnacles show a remarkably high level of interspecific variation compared with other barnacles. We document that variation in larval attachment devices are specifically related to properties of the surface on which they attach and metamorphose. Mapping of the larval and sponge surface features onto a molecular-based phylogeny showed that sponge symbiosis evolved separately at least three times within barnacles, with the same adaptive features being found in all larvae irrespective of phylogenetic relatedness. Furthermore, the metamorphosis of two species proceeded very differently, with one species remaining superficially on the host and developing a set of white calcareous structures, the other embedding itself into the live host tissue almost immediately after settlement. We argue that such a high degree of evolutionary flexibility of barnacle larvae played an important role in the successful evolution of complex symbiotic relationships in both coral reefs and other marine systems.
DOI: 10.6084/m9.figshare.12254456
title: Table S2a-b. ML+BI parameters from Sponge symbiosis is facilitated by adaptive evolution of larval sensory and attachment structures in barnacles

description: Symbiotic relations and range of host usage are prominent in coral reefs and crucial to the stability of such systems. In order to explain how symbiotic relations are established and evolve, we used sponge-associated barnacles to ask (1) Does larval settlement on sponge hosts require novel adaptations facilitating symbiosis? (2) How do larvae settle and start life on their hosts? (3) How has this remarkable symbiotic lifestyle involving many barnacle species evolved? We found that the larvae (cyprids) of sponge-associated barnacles show a remarkably high level of interspecific variation compared with other barnacles. We document that variation in larval attachment devices are specifically related to properties of the surface on which they attach and metamorphose. Mapping of the larval and sponge surface features onto a molecular-based phylogeny showed that sponge symbiosis evolved separately at least three times within barnacles, with the same adaptive features being found in all larvae irrespective of phylogenetic relatedness. Furthermore, the metamorphosis of two species proceeded very differently, with one species remaining superficially on the host and developing a set of white calcareous structures, the other embedding itself into the live host tissue almost immediately after settlement. We argue that such a high degree of evolutionary flexibility of barnacle larvae played an important role in the successful evolution of complex symbiotic relationships in both coral reefs and other marine systems.