cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26763628
title: Supplementary Material for: Association between constipation and the risk of Parkinson’s disease among participants in the UK Biobank

description: Introduction: Constipation is common in patients with Parkinson’s disease (PD), but its impact on incident PD remains uncertain. We aimed to prospectively investigate constipation symptoms and the risk of PD.
Methods: Participants without PD at baseline from the UK Biobank were included in the study. Information on the regular use of laxatives, bowel movement frequency, and the frequency of hard or lumpy stools was collected. Incident PD was defined by the ICD-10 code. Cox proportional hazards models were used to assess the association between constipation symptoms and incident PD.
Results: In the analysis of regular laxative use and PD, 490,797 participants were included and 2,735 incident PD were detected. The multivariable adjusted HR of PD in participants who regularly used laxatives was 1.99 (95% confidence interval [CI], 1.70–2.33) compared with those not. In the analysis of bowel movement frequency and hard or lumpy stools and PD, 170,017 participants were included and 519 incident PD were detected. The multivariable adjusted HRs were 2.16 (95% CI, 1.74–2.68) and 2.57 (95% CI, 2.00–3.31) for participants with a bowel movement frequency of 3–6 times/week and &lt;3 times/week, respectively, compared with those with a bowel movement frequency of ≥7 times/week; compared with participants who never had hard or lumpy stools, multivariable adjusted HRs were 1.31 (95% CI, 1.07–1.60), 2.32 (95% CI, 1.77–3.05), and 2.94 (95% CI, 2.14–4.05) for those who sometimes had hard or lumpy stools, often had hard or lumpy stools, and most of time/always had hard or lumpy stools, respectively. 
Conclusions: Constipation measured by the regular use of laxatives, bowel movement frequency, and the frequency of hard or lumpy stools was significantly associated with an increased risk of incident PD.
DOI: 10.6084/m9.figshare.26736921
title: Additional file 4 of Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis

description: Supplementary Material 4. Identifications of microbes in the SIM cohort
DOI: 10.6084/m9.figshare.26736918
title: Additional file 3 of Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis

description: Supplementary Material 3. The summary of sequencing reads of 142 samples
DOI: 10.6084/m9.figshare.26763175
title: Supplementary Material for: Tumor Treating Fields (TTFields) Therapy and Lomustine Chemotherapy for the Treatment of Unresectable Progressive Glioblastoma

description: Introduction: Tumor Treating Fields (TTFields) therapy used concomitantly with maintenance temozolomide through second progression after radio-chemotherapy, is associated with improved survival outcomes compared to adjuvant temozolomide alone in individuals with newly-diagnosed (nd) glioblastoma (GBM). Lomustine (CCNU) is frequently used as monotherapy or concomitant with other chemotherapy regimens as second-line treatment for recurrent GBM (rGBM). 
Case presentation: We report a 59-year-old female patient diagnosed with MGMT-promoter methylated (mMGMT), isocitrate dehydrogenase-wildtype (IDHwt) GBM (World Health Organization Grade 4) who received TTFields therapy concomitant with first- and second-line chemotherapy following partial resection. The patient experienced tumor pseudoprogression/progression after three cycles of maintenance temozolomide/TTFields therapy and again after a further two cycles of procarbazine/CCNU/TTFields therapy, and was then switched to CCNU/TTFields therapy. During 18 months of treatment with concomitant TTFields therapy and CCNU, the patient experienced regression/reduction of both tumor volume and perifocal edema with tolerable hematotoxicity, and was able to maintain a high rate of TTFields therapy usage. The patient ultimately died after developing chemotherapy-related acute myeloid leukemia. 
Conclusion: This patient case is reflective of the EF-14 outcome using TTFields therapy beyond first progression concomitantly with chemotherapy. The observations from this case suggest that TTFields therapy concomitant with CCNU is a valuable treatment modality in patients with GBM, in this context.
DOI: 10.6084/m9.figshare.26736924
title: Additional file 5 of Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis

description: Supplementary Material 5. Differentially expressed genes between IM and CTRLs
DOI: 10.4121/18c744fe-b047-4bd7-9bb9-b6e2b5da74ed
title: Data underlying the publication: Risk assessment methods for water resource recovery for the production of bio-composite materials: Literature review and future research directions

description:  Bio-composite materials made from resources recovered from the water cycle are the future of the holistic approach towards sustainable wastewater treatment. The raw ingredients for these materials are coming from con- taminated sources such as wastewater resources, water plants from surface water etc.. Thus, different risks like human health, environmental and product quality risks need to be assessed. Existing literature was analysed regarding these risks, especially methods concerning the risk assessment in wastewater and drinking water treatment and water/wastewater-based resource recovery for reuse. The reviewed literature identified several risk assessment methods such as FMEA, FMECA, FTA, QMRA and QCRA as frequently used ones for these purposes. However, no dedicated methods were identified for the corresponding risk assessments related to bio-composite materials representing key knowledge gaps. The literature review also showed that the above identified risk assessment methods cannot be directly applied for bio-composite materials as many required input data are missing. To overcome above gaps, future research directions have been identified. These include use of qualitative risk assessment methods such as HAZOP and ETA to first identify hazards and map the risks. Once this is done, QMRA and QCRA could be used in combination with Monte Carlo analysis to assess the actual risks.
DOI: 10.15468/dl.xxhqer
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON (((147.713728 -34.430876, 147.713728 -34.435368, 147.71822 -34.435368, 147.71822 -34.430876, 147.713728 -34.430876)), ((147.71822 -34.435368, 147.71822 -34.437614, 147.722712 -34.437614, 147.722712 -34.435368, 147.71822 -34.435368)), ((147.722712 -34.435368, 147.724957 -34.435368, 147.724957 -34.430876, 147.722712 -34.430876, 147.722712 -34.435368)), ((147.724957 -34.435368, 147.724957 -34.43986, 147.731695 -34.43986, 147.731695 -34.435368, 147.724957 -34.435368)))"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071224-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26738055.v1
title: Additional file 3 of Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.26736924.v1
title: Additional file 5 of Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis

description: Supplementary Material 5. Differentially expressed genes between IM and CTRLs
DOI: 10.6084/m9.figshare.26743658.v1
title: Additional file 2 of The potential of new nicotine and tobacco products as tools for people who smoke to quit combustible cigarettes – a systematic review of common practices and guidance towards a robust study protocol to measure cessation efficacy

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.26763341.v1
title: <i>Helicobacter pylori</i> infection delays neutrophil apoptosis and exacerbates inflammatory response

description: <b>Aim:</b> Understanding molecular mechanisms of <i>Helicobacter pylori</i> (<i>H. pylori</i>)-induced inflammation is important for developing new therapeutic strategies for gastrointestinal diseases. <b>Materials & methods:</b> We designed an <i>H. pylori</i>-neutrophil infection model and explored the effects of <i>H. pylori</i> infection on neutrophils. <b>Results:</b><i>H. pylori</i> infected neutrophils showed a low level of apoptosis. <i>H. pylori</i> stimulation activated the NACHT/LRR/PYD domain-containing protein 3 (NLRP3)-gasdermin-D (GSDMD) pathway for interleukin (IL)-1β secretion. However, IL-1β secretion was not completely dependent on GSDMD, as inhibition of autophagy significantly reduced IL-1β release, and autophagy-related molecules were significantly upregulated in <i>H. pylori</i>-infected neutrophils. <b>Conclusion:</b> Therefore, <i>H. pylori</i> infection inhibits neutrophils apoptosis and induces IL-1β secretion through autophagy. These findings may be utilized to formulate therapeutic strategies against <i>H. pylori</i> mediated chronic gastritis. <i>Helicobacter pylori</i> (<i>H. pylori</i>) is a common opportunistic morbigenous bacterium worldwide and associated with gastrointestinal diseases. <i>H. pylori</i> strain ATCC 11637 was used in this study. We designed a <i>H. pylori</i> neutrophils infection model <i>in vitro</i> utilizing <i>in vivo</i> harvested neutrophils. Pathological tissue analysis were carried out by multiplexed immunohistochemistry. The <i>H. pylori</i> infected neutrophils showed a lower frequency of annexin V-labeling and upregulation of CXCR4. <i>H. pylori</i> stimulation promote the activation of the NLRP3-GSDMD-IL1β pathway. Autophagy inhibitor significantly reduced IL-1β release and autophagy related molecules were upregulated significantly in <i>H. pylori</i> infected neutrophils. <i>H. pylori</i> inhibited neutrophil apoptosis and prolonged neutrophil survival. The inhibition of neutrophil apoptosis by <i>H. pylori</i> was mediated by inhibition of caspase-3 activation. <i>H. pylori</i> infection induced IL-1β secretion by neutrophils via an autophagy-dependent mechanism.
DOI: 10.15468/dl.8yjg3y
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON (((147.998945 -34.392698, 147.998945 -34.399435, 147.996699 -34.399435, 147.996699 -34.401681, 147.998945 -34.401681, 147.998945 -34.403927, 148.001191 -34.403927, 148.001191 -34.408418, 148.007928 -34.408418, 148.007928 -34.41291, 148.016911 -34.41291, 148.016911 -34.406173, 148.014666 -34.406173, 148.014666 -34.399435, 148.01242 -34.399435, 148.01242 -34.401681, 148.001191 -34.401681, 148.001191 -34.392698, 147.998945 -34.392698)), ((148.016911 -34.41291, 148.016911 -34.415156, 148.005682 -34.415156, 148.005682 -34.417402, 148.007928 -34.417402, 148.007928 -34.428631, 148.005682 -34.428631, 148.005682 -34.430876, 148.001191 -34.430876, 148.001191 -34.437614, 148.005682 -34.437614, 148.005682 -34.435368, 148.007928 -34.435368, 148.007928 -34.444351, 148.01242 -34.444351, 148.01242 -34.437614, 148.016911 -34.437614, 148.016911 -34.435368, 148.014666 -34.435368, 148.014666 -34.421893, 148.021403 -34.421893, 148.021403 -34.41291, 148.016911 -34.41291)))"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071225-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26744138.v1
title: Additional file 1 of Deep migration learning-based recognition of diseases and insect pests in Yunnan tea under complex environments

description: Supplementary material 1
DOI: 10.6084/m9.figshare.26744201
title: Additional file 3 of Deep migration learning-based recognition of diseases and insect pests in Yunnan tea under complex environments

description: Supplementary material 3
DOI: 10.6084/m9.figshare.26763409.v1
title: Supplementary Material for: Rivaroxaban for thromboembolism prophylaxis in patients with nephrotic syndrome: A single-arm, prospective study

description: Objectives: Thromboembolism is a recognized complication of nephrotic syndrome (NS). Evidence supporting the use of rivaroxaban to prevent NS-related thrombosis is limited and controversial. This study aimed to explore the impact of NS on rivaroxaban pharmacokinetics and to collect observational data on the efficacy and safety of rivaroxaban as primary thromboprophylaxis in patients with NS. Methods: This prospective study analyzed 141 patients with NS who received rivaroxaban (10 mg/day) for thromboprophylaxis. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to measure the trough and peak plasma concentrations (Ctrough and Cmax) of rivaroxaban. The influence of clinical and genetic factors on these concentrations was examined using multivariate logistic regression. Results: The median Cmax and Ctrough were 68.5 ng/mL (IQR, 31.7-105.5 ng/mL) and 4.4 ng/mL (IQR, 1.2-11.9 ng/mL), respectively. The incidence of thromboembolic events (TEs) was 12.8%, while that of bleeding events was 14.2%, although all were classified as minor. Albumin level was the most significant factor affecting Cmax (ρ = 0.55; P &lt; 0.001) and was also significantly associated with TEs (0.81; 0.71-0.91 per 1.0 g/dL increase; P = 0.001) and bleeding risks (1.11; 1.03-1.19 per 1.0 g/dL increase; P = 0.008). Single nucleotide polymorphisms (SNPs) in the ABCB1 gene significantly influenced Ctrough but were not associated with clinical outcomes. Conclusion: Hypoalbuminemia significantly affects the pharmacokinetics of rivaroxaban in NS patients. A dose-adjustment strategy based on rivaroxaban concentrations, accounting for variable albumin levels, may improve the safety and efficacy of thromboprophylaxis in this population.
DOI: 10.6084/m9.figshare.26074273
title: Additional file 2 of Effect of plant communities on bacterial and fungal communities in a Central European grassland

description: Additional file 2.
DOI: 10.15468/dl.z5pdwq
title: Occurrence Download

description: A dataset containing 425 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Cuscuta monogyna Vahl"
 ]
}

 The dataset includes 425 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071226-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26737176.v1
title: Additional file 12 of Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes

description: Supplementary material 12: Supplementary Table 5.
DOI: 10.15468/dl.yqe46d
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((148.351535 -34.424139, 148.351535 -34.430876, 148.347044 -34.430876, 148.347044 -34.435368, 148.351535 -34.435368, 148.351535 -34.437614, 148.353781 -34.437614, 148.353781 -34.435368, 148.358273 -34.435368, 148.358273 -34.430876, 148.360519 -34.430876, 148.360519 -34.428631, 148.358273 -34.428631, 148.358273 -34.424139, 148.351535 -34.424139))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071227-240626123714530/datasets/export for details.
DOI: 10.6084/m9.figshare.26739540
title: Additional file 3 of Total antioxidant status levels in malaria: a systematic review and meta-analysis

description: Supplementary file 3.
DOI: 10.6084/m9.figshare.26739537
title: Additional file 2 of Total antioxidant status levels in malaria: a systematic review and meta-analysis

description: Supplementary file 2.
DOI: 10.6084/m9.figshare.26737215.v1
title: Additional file 11 of Comprehensive meta-analysis of severe fever with thrombocytopenia syndrome virus infections in humans, vertebrate hosts and questing ticks

description: Additional file 11: Figure S4. Funnel plot for assessing publication bias in studies reporting RNA prevalence of SFTSV in humans (a), vertebrate hosts (b) and ticks (c).
DOI: 10.4121/18c744fe-b047-4bd7-9bb9-b6e2b5da74ed.v1
title: Data underlying the publication: Risk assessment methods for water resource recovery for the production of bio-composite materials: Literature review and future research directions

description:  Bio-composite materials made from resources recovered from the water cycle are the future of the holistic approach towards sustainable wastewater treatment. The raw ingredients for these materials are coming from con- taminated sources such as wastewater resources, water plants from surface water etc.. Thus, different risks like human health, environmental and product quality risks need to be assessed. Existing literature was analysed regarding these risks, especially methods concerning the risk assessment in wastewater and drinking water treatment and water/wastewater-based resource recovery for reuse. The reviewed literature identified several risk assessment methods such as FMEA, FMECA, FTA, QMRA and QCRA as frequently used ones for these purposes. However, no dedicated methods were identified for the corresponding risk assessments related to bio-composite materials representing key knowledge gaps. The literature review also showed that the above identified risk assessment methods cannot be directly applied for bio-composite materials as many required input data are missing. To overcome above gaps, future research directions have been identified. These include use of qualitative risk assessment methods such as HAZOP and ETA to first identify hazards and map the risks. Once this is done, QMRA and QCRA could be used in combination with Monte Carlo analysis to assess the actual risks.
DOI: 10.6084/m9.figshare.26744291
title: Additional file 6 of Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid

description: Additional file 6.
DOI: 10.6084/m9.figshare.26744285.v1
title: Additional file 5 of Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid

description: Additional file 5.
DOI: 10.6084/m9.figshare.26740205.v1
title: Additional file 6 of Construction of a high-density genetic map and QTL localization of body weight and wool production related traits in Alpine Merino sheep based on WGR

description: Supplementary Material 6
DOI: 10.15468/dl.z3nwdt
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((148.591836 -34.430876, 148.591836 -34.433122, 148.594082 -34.433122, 148.594082 -34.435368, 148.596327 -34.435368, 148.596327 -34.430876, 148.591836 -34.430876))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071229-240626123714530/datasets/export for details.
DOI: 10.5281/zenodo.13328723
title: PySCENIC reduced test dataset for workflow testing

description: Reduced size test dataset for workflow components of PySCENIC, including expected results (inputs for subsequent steps), directly collected or derived from https://github.com/aertslab/SCENICprotocol/tree/master/example .
DOI: 10.5281/zenodo.13328724
title: PySCENIC reduced test dataset for workflow testing

description: Reduced size test dataset for workflow components of PySCENIC, including expected results (inputs for subsequent steps), directly collected or derived from https://github.com/aertslab/SCENICprotocol/tree/master/example .
DOI: 10.6084/m9.figshare.26737266.v1
title: Additional file 2 of Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

description: Supplementary Material 2
DOI: 10.15468/dl.r3ypz5
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Peromyscus felipensis Merriam, 1898"
 ]
}

 The dataset includes 7 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071230-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sgn2fn
title: Occurrence Download

description: A dataset containing 1196762 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((18.36988 -34.10131, 18.76361 -34.10131, 18.76361 -33.80608, 18.36988 -33.80608, 18.36988 -34.10131))",
 "Year is greater than or equal to 2000",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
}

 The dataset includes 1196762 records from 148 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071223-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26744624
title: Additional file 1 of Genome-wide analysis of MYB transcription factor family and AsMYB1R subfamily contribution to ROS homeostasis regulation in Avena sativa under PEG-induced drought stress

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.26737026.v1
title: Additional file 2 of Novel hypoxia- and lactate metabolism-related molecular subtyping and prognostic signature for colorectal cancer

description: Supplementary Material 2.
DOI: 10.15468/dl.kt73sm
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON (((148.798449 -34.437614, 148.805187 -34.437614, 148.805187 -34.435368, 148.802941 -34.435368, 148.802941 -34.430876, 148.798449 -34.430876, 148.798449 -34.437614)), ((148.798449 -34.437614, 148.796204 -34.437614, 148.796204 -34.43986, 148.798449 -34.43986, 148.798449 -34.437614)))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071231-240626123714530/datasets/export for details.
DOI: 10.6084/m9.figshare.26738418.v1
title: Additional file 1 of Entourage: all-in-one sequence analysis software for genome assembly, virus detection, virus discovery, and intrasample variation profiling

description: Additional file1: Raw outputs generated by Entourage from the analysis of Khan et al.’s dataset, containing 6 tables. These include (i) read cleaning results, (ii) read subtraction results, (iii) read assembly statistics, (iv) read back-mapping results, (v) the reports from the target detection module, and (vi) the report from the discovery module.
DOI: 10.6084/m9.figshare.26726348
title: Additional file 5 of No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

description: Table S5. Effect sizes and respective 95% confidence intervals of models including TPH2 data (XLSX 12 kb)
DOI: 10.6084/m9.figshare.26737269
title: Additional file 3 of Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.26738325.v1
title: Additional file 8 of A systematic review of experimentally tested implementation strategies across health and human service settings: evidence from 2010-2022

description: Supplementary Material 8.