cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/xgr83xy8pm.1
title: Proteomics and RNAseq of C1-RIBOTAC treatment in MDA-MB-231

description: C1-RIBOTAC is a small molecule RNA degrader developed in our lab that selectively binds to human pre-miR-155 in cells and recruits RnaseL to degrade the transcript. Some RNA-binding compounds were expected to elicit a biological response as they bind functional sites, but most binders would not be expected to affect biological function. In these latter cases, an alternative way to modulate RNA biology is by cleaving the target via a ribonuclease targeting chimera, where an RNA-binding molecule is appended to a heterocycle that binds and locally activates RNase L. Overlay of the substrate specificity for RNase L with the binding landscape of small molecules in this study revealed many favorable candidate binders that are inactive but could be potently bioactive when converted into a degrader. We provide proof-of-concept by design of a degrader of the precursor to disease-associated microRNA-155 (pre-miR-155) in multiple cell lines and disease settings. These studies illustrate that small molecule RNA-targeted degradation can be leveraged to convert avid, yet inactive, binding interactions into potent and specific modulators of RNA function. The uploaded datasets include global proteomics and total RNA-seq studies to evaluate the effect on C1-RIBOTAC on the proteome and transcriptome of MDA-MB-231 cells.
DOI: 10.17632/xgr83xy8pm.2
title: Proteomics and RNAseq of C1-RIBOTAC treatment in MDA-MB-231

description: C1-RIBOTAC is a small molecule RNA degrader developed in our lab that selectively binds to human pre-miR-155 in cells and recruits RnaseL to degrade the transcript. Some RNA-binding compounds were expected to elicit a biological response as they bind functional sites, but most binders would not be expected to affect biological function. In these latter cases, an alternative way to modulate RNA biology is by cleaving the target via a ribonuclease targeting chimera, where an RNA-binding molecule is appended to a heterocycle that binds and locally activates RNase L. Overlay of the substrate specificity for RNase L with the binding landscape of small molecules in this study revealed many favorable candidate binders that are inactive but could be potently bioactive when converted into a degrader. We provide proof-of-concept by design of a degrader of the precursor to disease-associated microRNA-155 (pre-miR-155) in multiple cell lines and disease settings. These studies illustrate that small molecule RNA-targeted degradation can be leveraged to convert avid, yet inactive, binding interactions into potent and specific modulators of RNA function. The uploaded datasets include global proteomics and total RNA-seq studies to evaluate the effect on C1-RIBOTAC on the proteome and transcriptome of MDA-MB-231 cells.
DOI: 10.17632/xgr83xy8pm.3
title: Proteomics and RNA-seq of RIBOTAC treatment in MDA-MB-231 cells

description: C1-RIBOTAC is a small molecule RNA degrader developed in our lab that selectively binds to human pre-miR-155 in cells and recruits RnaseL to degrade the transcript. Some RNA-binding compounds were expected to elicit a biological response as they bind functional sites, but most binders would not be expected to affect biological function.  In these latter cases, an alternative way to modulate RNA biology is by cleaving the target via a ribonuclease targeting chimera, where an RNA-binding molecule is appended to a heterocycle that binds and locally activates RNase L.  Overlay of the substrate specificity for RNase L with the binding landscape of small molecules in this study revealed many favorable candidate binders that are inactive but could be potently bioactive when converted into a degrader.  We provide proof-of-concept by design of a degrader of the precursor to disease-associated microRNA-155 (pre-miR-155) in multiple cell lines and disease settings.  These studies illustrate that small molecule RNA-targeted degradation can be leveraged to convert avid, yet inactive, binding interactions into potent and specific modulators of RNA function. The uploaded datasets include global proteomics and total RNA-seq studies to evaluate the effect on C1-RIBOTAC on the proteome and transcriptome of MDA-MB-231 cells.
DOI: 10.17632/xgr83xy8pm.4
title: Proteomics and RNA-seq of RIBOTAC treatment in MDA-MB-231 cells

description: C1-RIBOTAC is a small molecule RNA degrader developed in our lab that selectively binds to human pre-miR-155 in cells and recruits RnaseL to degrade the transcript. Some RNA-binding compounds were expected to elicit a biological response as they bind functional sites, but most binders would not be expected to affect biological function.  In these latter cases, an alternative way to modulate RNA biology is by cleaving the target via a ribonuclease targeting chimera, where an RNA-binding molecule is appended to a heterocycle that binds and locally activates RNase L.  Overlay of the substrate specificity for RNase L with the binding landscape of small molecules in this study revealed many favorable candidate binders that are inactive but could be potently bioactive when converted into a degrader.  We provide proof-of-concept by design of a degrader of the precursor to disease-associated microRNA-155 (pre-miR-155) in multiple cell lines and disease settings.  These studies illustrate that small molecule RNA-targeted degradation can be leveraged to convert avid, yet inactive, binding interactions into potent and specific modulators of RNA function. The uploaded datasets include global proteomics and total RNA-seq studies to evaluate the effect on C1-RIBOTAC on the proteome and transcriptome of MDA-MB-231 cells.
DOI: 10.17632/94x7pjvxvw.1
title: Data regarding anti-quorum sensing and antimicrobial activity of Melaleuca alternifolia and Salvia sclarea essential oil against Pseudomonas aeruginosa

description: Researchers are now looking for alternatives that reduce the virulence and pathogenic potential of the bacteria without killing it. It can be accomplished by interfering with the quorum sensing (QS) system of bacteria. In this article, we aim to determine the antimicrobial and anti-QS activity of Salvia sclarea and Melaleuca alternifolia essential oils. The sub-lethal concentration of these essential oils (EOs) was found with the help of a growth curve, and further experiments were carried out below this concentration. To check for their anti-quorum activity, a bioreporter strain E. coli pJN105LpSC11 (to measure the concentration of 3-oxo-C12-HSL) and Chromobacterium violaceum CV026 (to check for the reduction in the formation of violacein pigment) was used. Several virulence phenotype assays like pyocyanin, alginate, and protease production, along with swarming motility, were done. The effect of these essential oils on biofilm formation was also checked. The results were confirmed by checking the expression of genes by real-time PCR.
DOI: 10.17632/94x7pjvxvw.2
title: Data regarding anti-quorum sensing and antimicrobial activity of Melaleuca alternifolia and Salvia sclarea essential oil against Pseudomonas aeruginosa

description: Researchers are now looking for alternatives that reduce the virulence and pathogenic potential of the bacteria without killing it. It can be accomplished by interfering with the quorum sensing (QS) system of bacteria. In this article, we aim to determine the antimicrobial and anti-QS activity of Salvia sclarea and Melaleuca alternifolia essential oils. The sub-lethal concentration of these essential oils (EOs) was found with the help of a growth curve, and further experiments were carried out below this concentration. To check for their anti-quorum activity, a bioreporter strain E. coli pJN105LpSC11 (to measure the concentration of 3-oxo-C12-HSL) and Chromobacterium violaceum CV026 (to check for the reduction in the formation of violacein pigment) was used. Several virulence phenotype assays like pyocyanin, alginate, and protease production, along with swarming motility, were done. The effect of these essential oils on biofilm formation was also checked. The results were confirmed by checking the expression of genes by real-time PCR.
DOI: 10.17632/94x7pjvxvw.3
title: Data regarding anti-quorum sensing and antimicrobial activity of Melaleuca alternifolia and Salvia sclarea essential oil against Pseudomonas aeruginosa

description: Researchers are now looking for alternatives that reduce the virulence and pathogenic potential of the bacteria without killing it. It can be accomplished by interfering with the quorum sensing (QS) system of bacteria. In this article, we aim to determine the antimicrobial and anti-QS activity of Salvia sclarea and Melaleuca alternifolia essential oils. The sub-lethal concentration of these essential oils (EOs) was found with the help of a growth curve, and further experiments were carried out below this concentration. To check for their anti-quorum activity, a bioreporter strain E. coli pJN105LpSC11 (to measure the concentration of 3-oxo-C12-HSL) and Chromobacterium violaceum CV026 (to check for the reduction in the formation of violacein pigment) was used. Several virulence phenotype assays like pyocyanin, alginate, and protease production, along with swarming motility, were done. The effect of these essential oils on biofilm formation was also checked. The results were confirmed by checking the expression of genes by real-time PCR.
DOI: 10.17632/94x7pjvxvw.4
title: Data regarding anti-quorum sensing and antimicrobial activity of Melaleuca alternifolia and Salvia sclarea essential oil against Pseudomonas aeruginosa

description: Researchers are now looking for alternatives that reduce the virulence and pathogenic potential of the bacteria without killing it. It can be accomplished by interfering with the quorum sensing (QS) system of bacteria. In this article, we aim to determine the antimicrobial and anti-QS activity of Salvia sclarea and Melaleuca alternifolia essential oils. The sub-lethal concentration of these essential oils (EOs) was found with the help of a growth curve, and further experiments were carried out below this concentration. To check for their anti-quorum activity, a bioreporter strain E. coli pJN105LpSC11 (to measure the concentration of 3-oxo-C12-HSL) and Chromobacterium violaceum CV026 (to check for the reduction in the formation of violacein pigment) was used. Several virulence phenotype assays like pyocyanin, alginate, and protease production, along with swarming motility, were done. The effect of these essential oils on biofilm formation was also checked. The results were confirmed by checking the expression of genes by real-time PCR.
DOI: 10.17632/wtbpcrc6n6.1
title: Dataset Inertial Sensors for Hip Arthroplasty Rehabilitation

description: Review of the scope of inertial systems used in different applications to measure movements of the human body, postural sway and anticipatory movements related to the diagnosis and evaluation for Hip Arthroplasty Rehabilitation.
DOI: 10.5445/ir/1000142191
title: Dataset to the publication 'Topology optimization on two-dimensional manifolds'
DOI: 10.17632/k2dcvb7ygc.1
title: Appendix A. Supplementary data

description: Supplementary datasets related to this article are available in the online supplementary data.
DOI: 10.17632/7gyxppvfwc.1
title: Historical settlements in the Qiantang River Basin

description: This data includes the site longitude and latitude, elevation, slope direction and other relevant information.We suppposed that with the evolution of dynasties and the change of environment, the relevant information of data will change correspondingly.
DOI: 10.5445/ir/1000140474
title: Database: Ridge-type roughness - from turbulent channel flow to internal combustion engine
DOI: 10.17632/2b33bbwjdp.1
title: MatlabCode_RAM-HT

description: The programs reproduce reweighted atomic norm minimization based on Hankel-Toeplitz model (RAM-HT) and compare its performance with other algorithms, such as ANM-HT, RAM-T and ANM-T. More details and figures are shown in:
[1] Chu Y, Wei Z, Yang Z. New reweighted atomic norm minimization approach for line spectral estimation[J]. Signal Processing, 2023, 206: 108897.
DOI: 10.17632/vb8t6xktzg.1
title: Supplemental data files for: A relationship between the migration of crustal material, normal faulting, and gneiss domes in the vicinity of the Dinggye region, Central Himalaya: insights from the electrical structure

description: Supplemental data files for: A relationship between the migration of crustal material, normal faulting, and gneiss domes in the vicinity of the Dinggye region, Central Himalaya: insights from the electrical structure
DOI: 10.17632/vb8t6xktzg.2
title: Supplemental data files for: Relationship between the migration of crustal material and dynamic mechanism in the vicinity of the Dinggye region, Central Himalaya: insights from the 3-D electrical structure

description: Supplemental data files for: A relationship between the migration of crustal material, normal faulting, and gneiss domes in the vicinity of the Dinggye region, Central Himalaya: insights from the electrical structure
DOI: 10.5519/qd.pifvb20d
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (23 records)
DOI: 10.17632/jzm9wpghtm.1
title: Data on the relationship of personality and integrity among Malaysian Government Employees

description: This is a raw data on the relationship of personality and integrity among Malaysian Government Employees.  This data set is a useful source of reference for researchers, policymakers, human resource managers and psychology officers in public services in understanding relationship between empoyees' personality and integrity.
DOI: 10.17632/d852chv29f.1
title: The use of artificial intelligence systems in diagnosis of pneumonia via signs and symptoms A systematic review

description: Scientific research for publishing the article
DOI: 10.17632/mdtwk5bxn5.1
title: AllBert EinStein SCARAB data

description: AllBert EinStein is intended to reenter spheres of known size and material into the atmosphere to determine the percentage of kinetic energy converted to light. The zip file contains the raw SCARAB data for the different sizes, materials, and initial conditions run for the AllBert EinStein mission. 
The .zip folder is subdivided in :
a-1- is the simulation of the assumed reentry rocket body with the cage structure and an artificial meteoroid
b-4- are the simulations with iron spheres of different dimensions with the cage structure
m- are the artificial meteoroid simulations of different materials and sizes
DOI: 10.17632/jj75nm9d3m.1
title: Private tutoring of senior lower and upper secondary students and some influencing factors – Data from Vietnam.

description: The dataset provides large-scale evaluation data on the private tutoring status of senior lower and upper secondary senior students in Vietnam and some factors that affect their private tutoring. The questionnaire was built based on the PISA 2019 questionnaire framework, where the questions were adjusted to fit the private tutoring issues of grade 9 and grade 12 students in Vietnam. The survey sample was collected using a two-stage stratified sampling method with the participation of all 63 provinces and cities in Vietnam, divided into 6 economic regions: Northeast and Northwest, Red River Delta, North Central Coast and Central Highlands, South Central Coast, Central Highlands, and Mekong River Delta. The survey was conducted directly in May 2019 with feedback from 15,221 grade 9 students and 19,412 grade 12. The raw data is stored in an Excel spreadsheet and analyzed for descriptive statistics, specifically mean values, standard deviations, and ranges. The dataset is expected to benefit policy planners, educators, school managers, and teachers interested in the private tutoring of lower and upper secondary students.
DOI: 10.17632/t8tm3ygfff.1
title: Online Child Sexual Abuse BD

description: A concurrent mixed-method study was conducted among grade 9-10 students from four randomly selected secondary schools in both urban and rural areas. Quantitative data were collected by a self-administered questionnaire and qualitative data by a semi-structure in-depth interview guideline. Among 456 participants in quantitative strand, about 86% of girls and 91% of boys reported using the Internet.
DOI: 10.5445/ir/1000126087
title: Large characteristic lengths in 3D chiral elastic metamaterials
DOI: 10.5281/zenodo.7684965
title: Digital Tools for Handwriting Proficiency Evaluation in Children - DATASET

description: Data to support the findings in the conference paper L. G. Dui, E. Calogero, M. Malavolti, C. Termine, M. Matteucci and S. Ferrante, "Digital Tools for Handwriting Proficiency Evaluation in Children," <em>2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI)</em>, Athens, Greece, 2021, pp. 1-4, doi: 10.1109/BHI50953.2021.9508539. Characterization.xls: an Excel file with sheets: Characterization: Subject ID School ID Class Age Sex Hand Years since starting writing in cursive TabletSUS: score for the System Usability Scale referred to writing on tablet PenSUS: score for the System Usability Scale referred to writing on paper with the smart ink pen BVSCO-2: number of graphemes produced when writing on paper or tablet pen_tablet_data.mat: a Matlab file with indicators and their names, computed with tablet and pen data
DOI: 10.5281/zenodo.7684964
title: Digital Tools for Handwriting Proficiency Evaluation in Children - DATASET

description: Data to support the findings in the conference paper L. G. Dui, E. Calogero, M. Malavolti, C. Termine, M. Matteucci and S. Ferrante, "Digital Tools for Handwriting Proficiency Evaluation in Children," <em>2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI)</em>, Athens, Greece, 2021, pp. 1-4, doi: 10.1109/BHI50953.2021.9508539. Characterization.xls: an Excel file with sheets: Characterization: Subject ID School ID Class Age Sex Hand Years since starting writing in cursive TabletSUS: score for the System Usability Scale referred to writing on tablet PenSUS: score for the System Usability Scale referred to writing on paper with the smart ink pen BVSCO-2: number of graphemes produced when writing on paper or tablet pen_tablet_data.mat: a Matlab file with indicators and their names, computed with tablet and pen data
DOI: 10.5445/ir/1000096054
title: Software and example data for error grid analysis

description: Supplement of the article Grothe O, Kaplan A, Kouz K, Saugel B. "Computer program for error grid analysis in arterial blood pressure method comparison studies" to provide the error grid analysis suggested in Saugel B, Grothe O, Nicklas JY. "Error Grid Analysis for Arterial Pressure Method Comparison Studies. Anesthesia and analgesia 2018;126:1177-85.
DOI: 10.17632/gd4yfvryyh.1
title: List of  transcripts ifferentially expressed in acute promyelocytic cells treated with the CHK1 inhibitor MK-8776, compared to untreated ones (Franza et al., 2023)

description: The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia (APL) cells. Here we show the list of the 1055 transcripts that were found significantly differentially expressed in MK-8776-treated APL cells compared to untreated ones (FDR≤0.05; Benjamini–Hochberg correction). RNA samples have been amplified, fragmented, and labeled for array hybridization according to the manufacturer’s instruction. Samples were then hybridized ON, washed, stained, and scanned using the Affymetrix GeneChip Hybridization Oven 640, Fluidic Station 450 and Scanner 3000 7G (Thermo Fisher Scientific) to generate the raw data files.
DOI: 10.17632/gd4yfvryyh.2
title: List of the transcripts differentially expressed in ATRA-resistant acute promyelocytic leukemia cells treated with the CHK1 inhibitor MK-8776, compared to untreated cells (Franza et al., 2023)

description: The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia (APL) cells. Here we show the list of the 1055 transcripts that were found significantly differentially expressed in MK-8776-treated APL cells compared to untreated ones (FDR≤0.05; Benjamini–Hochberg correction). RNA samples have been amplified, fragmented, and labeled for array hybridization according to the manufacturer’s instruction. Samples were then hybridized ON, washed, stained, and scanned using the Affymetrix GeneChip Hybridization Oven 640, Fluidic Station 450 and Scanner 3000 7G (Thermo Fisher Scientific) to generate the raw data files.
DOI: 10.17632/n2vs8spdhz.1
title: Designs used in published therapeutic studies of rare superficial vascular anomalies: A systematic literature search

description: DATASET:
Dataset.csv : CSV format
Search terms.docx  : word format
DOI: 10.17632/n2vs8spdhz.2
title: Designs used in published therapeutic studies of rare superficial vascular anomalies: A systematic literature search

description: DATASET:
Dataset.csv : CSV format
DOI: 10.17632/kmrsfhjfd3.1
title: Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

description: scientific research for publishing the article
DOI: 10.5281/zenodo.7684943
title: Effect of intense x-ray free-electron laser transient gratings on the magnetic domain structure of Tm:YIG

description: Dataset for the publication "Effect of intense x-ray free-electron laser transient gratings on the magnetic domain structure of Tm:YIG" by V. Ukleev, et al.
DOI: 10.17632/zjk552r6x6.1
title: Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age

description: scientific research for publishing the article
DOI: 10.17632/rb7mdnkf9x.1
title: Effects of Annurca Flesh Apple Polyphenols in Human Thyroid Cancer Cell Lines

description: scientific research for publishing the article
DOI: 10.17632/3kn94vpcr4.1
title: Rapid Efficacy of anifrolumab in refractory cutaneous manifestations of systemic lupus erythematosus: a prospective study of 11 patients

description: Supplementary Figure 1 legend: Kaplan-Meier curves for the probability of reaching a CLASI-50 (left panel) or complete response (right panel). The median time to reach CLASI-A 50 was one month (95% CI 1-3). The median time to reach complete response was 6 months (95% CI 1-∞)

Supplementary Figure 2 legend: CLASI damage and SELENA-SLEDAI scores for 11 patients before and at weeks 4 and 16 of anifrolumab treatment. Black solid circles represent individuals. The red bars indicate median values. P-values were calculated using the Mann-Whitney U test. p<0.05 was considered significant. NS, non-significant; W, Week
DOI: 10.5445/ir/1000144208
title: Data-Analysis Notebooks for the Thesis 'Electron Microscopic Investigation of Superconducting Fe- and Cu-based Thin Films'
DOI: 10.17632/63d66xzhgw.1
title: Rapid escape of new SARS-CoV-2 Omicron variants from BA.2 directed antibody responses by Dijokaite-Guraliuc et al

description: Movies for the above paper in Cell Reports

Movie S1. Heat map to indicate the concentration of antibody interactions across the RBD surface from the set of potent antibodies previously reported against early pandemic virus4.
 
Movie S2. Heat map to indicate the concentration of antibody interactions across the RBD surface from the set of potent antibodies previously reported against Beta variant14.
 
Movie S3. Heat map to indicate the concentration of antibody interactions across the RBD surface from the set of potent antibodies previously reported against Omicron BA.113.
 
Movie S4. Heat map to indicate the concentration of antibody interactions across the RBD surface from the set of potent antibodies against BA.2 reported in this paper (spikes show the BA.2 mutations).