cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.27144012
title: <i>Supporting data for “</i><i>Targeting HAUS7 as a Therapeutic Approach</i><i>for Esophageal Squamous Cell Carcinoma</i><i>”</i>

description: The dataset established as part of the research on HAUS7 in esophageal squamous cell carcinoma (ESCC) elucidates the involvement of HAUS7 in ESCC progression through its interaction with γ-tubulin facilitated by the novel peptide HTIP1. The dataset incorporates raw and processed data encompassing diverse experimental modalities including western blotting, immunohistochemistry, microscopic imaging, and qPCR assay. Utilizing Prism software for analysis, the dataset encompasses comprehensive information on gene and protein expression profiles, cellular viability assessments, apoptotic assays, as well as observations on tumor growth and survival parameters derived from patient-derived xenograft models.
DOI: 10.25442/hku.27144012.v1
title: <i>Supporting data for “</i><i>Targeting HAUS7 as a Therapeutic Approach</i><i>for Esophageal Squamous Cell Carcinoma</i><i>”</i>

description: The dataset established as part of the research on HAUS7 in esophageal squamous cell carcinoma (ESCC) elucidates the involvement of HAUS7 in ESCC progression through its interaction with γ-tubulin facilitated by the novel peptide HTIP1. The dataset incorporates raw and processed data encompassing diverse experimental modalities including western blotting, immunohistochemistry, microscopic imaging, and qPCR assay. Utilizing Prism software for analysis, the dataset encompasses comprehensive information on gene and protein expression profiles, cellular viability assessments, apoptotic assays, as well as observations on tumor growth and survival parameters derived from patient-derived xenograft models.
DOI: 10.6084/m9.figshare.26730747
title: A significant correlation between ABA-induced seed-germination delay and salt tolerance of seedling in <i>Brassica napus</i>

description: Under abiotic stresses, such as salt stress, abscisic acid (ABA) production is induced and enhances stress tolerance. ABA is also an important plant hormone that regulates vital biological responses, including seed gemination delay. However, the interplay between stress conditions and biological responses is not well understood. Previously, we reported a wide salt tolerance variation among <i>Brassica napus</i> varieties. This range of salt tolerance makes <i>B. napus</i> ideal for exploring the relationship between salt tolerance and ABA-induced seed germination delay. First, we investigated the ABA-induced seed-germination delay of 22 <i>B. napus</i> varieties, each with different salt tolerances. We observed that highly salt-tolerant varieties exhibited significant seed-germination delays when exposed to increasing ABA concentrations. Additionally, among the varieties, exogenous ABA induced a range of different germination delays, suggesting a significant correlation between germination delay and salt tolerance at the seedling stage. Expression analysis, with and without ABA treatment, for several genes involved in the ABA signalling pathway and downstream was also performed at seed germination. The results suggest the potential involvement of <i>ABI5</i> and <i>SOS1</i> in both germination regulation and salt tolerance.
DOI: 10.6084/m9.figshare.26730747.v1
title: A significant correlation between ABA-induced seed-germination delay and salt tolerance of seedling in <i>Brassica napus</i>

description: Under abiotic stresses, such as salt stress, abscisic acid (ABA) production is induced and enhances stress tolerance. ABA is also an important plant hormone that regulates vital biological responses, including seed gemination delay. However, the interplay between stress conditions and biological responses is not well understood. Previously, we reported a wide salt tolerance variation among <i>Brassica napus</i> varieties. This range of salt tolerance makes <i>B. napus</i> ideal for exploring the relationship between salt tolerance and ABA-induced seed germination delay. First, we investigated the ABA-induced seed-germination delay of 22 <i>B. napus</i> varieties, each with different salt tolerances. We observed that highly salt-tolerant varieties exhibited significant seed-germination delays when exposed to increasing ABA concentrations. Additionally, among the varieties, exogenous ABA induced a range of different germination delays, suggesting a significant correlation between germination delay and salt tolerance at the seedling stage. Expression analysis, with and without ABA treatment, for several genes involved in the ABA signalling pathway and downstream was also performed at seed germination. The results suggest the potential involvement of <i>ABI5</i> and <i>SOS1</i> in both germination regulation and salt tolerance.
DOI: 10.6084/m9.figshare.26977933
title: Effect of rock phosphate direct application on tropical legumes under different soil types of Sudan Savanna

description: Direct application of low-grade rock phosphate (RP) is a less expensive alternative than the application of chemical phosphorus (P) for small holders relying on nutrient-deficient weathered soils. However, the effect of RP application on growth and yield is unstable for different crop species and soil water conditions. To identify legume species effective for RP direct application, five tropical legumes (cowpea, groundnut, bambara nut, mung bean, and soybean) were tested under two soil types with different water-holding capacities in Sudan Savanna; Lixisols and Plinthosols. The experiment was conducted under three conditions of P treatment, namely, RP application, triple super phosphate (TSP) application, and no phosphorus fertilizer application (0P). Under RP treatment, higher grain yield was obtained in Lixisols, which had a higher water-holding capacity. However, the yield increase was suppressed in the year with more rainfall owing to drastic changes in the soil moisture content, which caused excessive soil moisture stress during vegetative growth periods. Among the five legume species, cowpea and groundnut showed higher grain yields under the RP treatment than did other species. RP application increased shoot biomass but caused small changes in the shoot P and N concentrations. Soybean in Plinthosols had the highest yield ratio of RP/0P, but the absolute yield was low because of the insufficient soil water availability caused by the low water-holding capacity. RP direct application can assist shoot growth and yield, but it rarely compensates for basal yield differences between soil types and among legume species.
DOI: 10.6084/m9.figshare.26977933.v1
title: Effect of rock phosphate direct application on tropical legumes under different soil types of Sudan Savanna

description: Direct application of low-grade rock phosphate (RP) is a less expensive alternative than the application of chemical phosphorus (P) for small holders relying on nutrient-deficient weathered soils. However, the effect of RP application on growth and yield is unstable for different crop species and soil water conditions. To identify legume species effective for RP direct application, five tropical legumes (cowpea, groundnut, bambara nut, mung bean, and soybean) were tested under two soil types with different water-holding capacities in Sudan Savanna; Lixisols and Plinthosols. The experiment was conducted under three conditions of P treatment, namely, RP application, triple super phosphate (TSP) application, and no phosphorus fertilizer application (0P). Under RP treatment, higher grain yield was obtained in Lixisols, which had a higher water-holding capacity. However, the yield increase was suppressed in the year with more rainfall owing to drastic changes in the soil moisture content, which caused excessive soil moisture stress during vegetative growth periods. Among the five legume species, cowpea and groundnut showed higher grain yields under the RP treatment than did other species. RP application increased shoot biomass but caused small changes in the shoot P and N concentrations. Soybean in Plinthosols had the highest yield ratio of RP/0P, but the absolute yield was low because of the insufficient soil water availability caused by the low water-holding capacity. RP direct application can assist shoot growth and yield, but it rarely compensates for basal yield differences between soil types and among legume species.
DOI: 10.6084/m9.figshare.27060857
title: Effects of depressions and drainage systems on soybean (<i>Glycine max</i> (L.) Merill) growth during the early growth stages under excess water stress conditions

description: Soybean (<i>Glycine max</i> (L.) Merill) productivity is severely compromised under conditions of excess water, particularly during the early growth stages. Depressions in converted paddy fields are believed to significantly contribute to excess water stress. Farmers typically use drainage systems, such as field ditches and pipe drains to improve field drainage. In this study, we aimed to evaluate the impacts of depressions and drainage systems on soybean growth during the early growth stages in farming fields. Using uncrewed aerial vehicles and imaging processing software, we observed the soybean coverage ratio at two and four weeks after sowing. We analyzed the relationship between the coverage ratio and depression depth, distance from field ditches, and distance from pipe drains. Depressions deeper than 2 cm were present in all study fields, and the coverage ratio increase from 2 to 4 weeks after sowing was negatively correlated with depression depth. Although the distance from pipe drains was negatively related to the coverage ratio increase, the distance from field ditches had a limited effect. The construction of pipe drains significantly improved the coverage ratio increase, particularly in areas with deep depressions and near pipe drains, by up to 23.0 times in this study. Therefore, constructing pipe drains near depressions is an effective way to mitigate the impact of depressions and excess water stress on soybean growth during the early stages. Our results will be useful for developing strategies to improve drainage and soybean growth during early growth stages.
DOI: 10.6084/m9.figshare.27060857.v1
title: Effects of depressions and drainage systems on soybean (<i>Glycine max</i> (L.) Merill) growth during the early growth stages under excess water stress conditions

description: Soybean (<i>Glycine max</i> (L.) Merill) productivity is severely compromised under conditions of excess water, particularly during the early growth stages. Depressions in converted paddy fields are believed to significantly contribute to excess water stress. Farmers typically use drainage systems, such as field ditches and pipe drains to improve field drainage. In this study, we aimed to evaluate the impacts of depressions and drainage systems on soybean growth during the early growth stages in farming fields. Using uncrewed aerial vehicles and imaging processing software, we observed the soybean coverage ratio at two and four weeks after sowing. We analyzed the relationship between the coverage ratio and depression depth, distance from field ditches, and distance from pipe drains. Depressions deeper than 2 cm were present in all study fields, and the coverage ratio increase from 2 to 4 weeks after sowing was negatively correlated with depression depth. Although the distance from pipe drains was negatively related to the coverage ratio increase, the distance from field ditches had a limited effect. The construction of pipe drains significantly improved the coverage ratio increase, particularly in areas with deep depressions and near pipe drains, by up to 23.0 times in this study. Therefore, constructing pipe drains near depressions is an effective way to mitigate the impact of depressions and excess water stress on soybean growth during the early stages. Our results will be useful for developing strategies to improve drainage and soybean growth during early growth stages.
DOI: 10.25442/hku.27109150
title: Supporting data for "Modulation of alpha-4 beta-2 nicotinic acetylcholine receptor attenuates systemic inflammation and neuroinflammation triggered by laparotomy"

description: The scope of the data in this research project focuses on investigating the effects of an alpha-4 beta-2 nicotinic acetylcholine receptor agonist targeting postoperative neuroinflammation and cognitive decline in a murine model. The study includes a sample size of 150 mice, encompassing surgery group, surgery + agonist group and anaesthesia groups, to assess the therapeutic potential of the these agonists in mitigating neuroinflammatory responses and cognitive impairments following surgery. The data files comprise behavioral evaluations related to cognitive function, neuroinflammatory markers like pro-inflammtory cytokine or anti-inflmmatory cytokine, glial cell activation including astrocyte staining and microglia staining, as well as protein markers related to synaptic plasticity and memory function. This study offers a detailed insight into the experimental outcomes and molecular changes associated with the agonist treatment, aiming to elucidate the mechanisms underlying its neuroprotective and cognitive-enhancing properties.
DOI: 10.25442/hku.27109150.v1
title: Supporting data for "Modulation of alpha-4 beta-2 nicotinic acetylcholine receptor attenuates systemic inflammation and neuroinflammation triggered by laparotomy"

description: The scope of the data in this research project focuses on investigating the effects of an alpha-4 beta-2 nicotinic acetylcholine receptor agonist targeting postoperative neuroinflammation and cognitive decline in a murine model. The study includes a sample size of 150 mice, encompassing surgery group, surgery + agonist group and anaesthesia groups, to assess the therapeutic potential of the these agonists in mitigating neuroinflammatory responses and cognitive impairments following surgery. The data files comprise behavioral evaluations related to cognitive function, neuroinflammatory markers like pro-inflammtory cytokine or anti-inflmmatory cytokine, glial cell activation including astrocyte staining and microglia staining, as well as protein markers related to synaptic plasticity and memory function. This study offers a detailed insight into the experimental outcomes and molecular changes associated with the agonist treatment, aiming to elucidate the mechanisms underlying its neuroprotective and cognitive-enhancing properties.
DOI: 10.25442/hku.27117193
title: Supporting data for "Optimizing the mHealth intervention effect on addictive behaviors"

description: The rapid rise of mHealth has transformed healthcare delivery, and been found effective in addictive behaviors. However, challenges on participant disengagement and insufficient descriptions of the intervention content hinder further research. This thesis explored the mechanisms behind effective mHealth interventions for smoking cessation and alcohol reduction by examining both human-level factors (engagement) and intervention-specific content (Behavior change techniques, BCTs).A community-based, two-arm, parallel group, pragmatic, cluster-randomized controlled trial was conducted in 2017 to test the effectiveness of a 3-month mHealth chat-based smoking cessation intervention. It integrated regular cessation-specific messages and real-time support by a live counselor. Biochemically validated smoking abstinence was measured at 3 and 6 months. Similarly, a two-arm, parallel group, pragmatic and individual-randomized controlled trial for risky alcohol drinkers (AUDIT 8+) visiting AEDs was started in 2022. This intervention consisted of brief alcohol advice in-person at baseline, followed by 3 months of mHealth chat-based support with regular alcohol-related messages and real-time support. Study outcomes include weekly alcohol consumption, AUDIT score, binge drinking, heavy drinking, planned drinking, alcohol-related harm and AED re-attendance. Secondary analyses included participants from the intervention groups of both trials. Weekly responses to the regular messages were characterized as engagement, and analyzed using group-based trajectory modelling. Poisson regression with robust variance or linear regression were used to examine the associations between engagement trajectories and study outcomes. Only participants who interacted with counselors during real-time support were included for characterizing BCTs. Predefined messages were excluded for analyzing, with only the counselor’s messages during real-time support being coded. Machine learning approaches were employed to identify predictive BCTs for smoking abstinence, and Poisson regression with robust variance was used to examine associations between these BCTs and abstinence outcomes. The associations between coded BCTs and alcohol-related outcomes were tested using Poisson or linear regression in alcohol reduction trial.Different patterns of engagement were observed in smoking cessation and alcohol reduction intervention. Results from both studies indicated that higher engagement levels were associated with better outcomes. Significant BCTs associated with smoking cessation and alcohol reduction were identified. Future studies should focus on enhancing participant engagement, and incorporating effective BCTs to optimize the impact of mHealth interventions.
DOI: 10.25442/hku.27117193.v1
title: Supporting data for "Optimizing the mHealth intervention effect on addictive behaviors"

description: The rapid rise of mHealth has transformed healthcare delivery, and been found effective in addictive behaviors. However, challenges on participant disengagement and insufficient descriptions of the intervention content hinder further research. This thesis explored the mechanisms behind effective mHealth interventions for smoking cessation and alcohol reduction by examining both human-level factors (engagement) and intervention-specific content (Behavior change techniques, BCTs).A community-based, two-arm, parallel group, pragmatic, cluster-randomized controlled trial was conducted in 2017 to test the effectiveness of a 3-month mHealth chat-based smoking cessation intervention. It integrated regular cessation-specific messages and real-time support by a live counselor. Biochemically validated smoking abstinence was measured at 3 and 6 months. Similarly, a two-arm, parallel group, pragmatic and individual-randomized controlled trial for risky alcohol drinkers (AUDIT 8+) visiting AEDs was started in 2022. This intervention consisted of brief alcohol advice in-person at baseline, followed by 3 months of mHealth chat-based support with regular alcohol-related messages and real-time support. Study outcomes include weekly alcohol consumption, AUDIT score, binge drinking, heavy drinking, planned drinking, alcohol-related harm and AED re-attendance. Secondary analyses included participants from the intervention groups of both trials. Weekly responses to the regular messages were characterized as engagement, and analyzed using group-based trajectory modelling. Poisson regression with robust variance or linear regression were used to examine the associations between engagement trajectories and study outcomes. Only participants who interacted with counselors during real-time support were included for characterizing BCTs. Predefined messages were excluded for analyzing, with only the counselor’s messages during real-time support being coded. Machine learning approaches were employed to identify predictive BCTs for smoking abstinence, and Poisson regression with robust variance was used to examine associations between these BCTs and abstinence outcomes. The associations between coded BCTs and alcohol-related outcomes were tested using Poisson or linear regression in alcohol reduction trial.Different patterns of engagement were observed in smoking cessation and alcohol reduction intervention. Results from both studies indicated that higher engagement levels were associated with better outcomes. Significant BCTs associated with smoking cessation and alcohol reduction were identified. Future studies should focus on enhancing participant engagement, and incorporating effective BCTs to optimize the impact of mHealth interventions.
DOI: 10.25442/hku.27108862
title: Supporting data for "1.7-μm mode-locked fiber laser for nonlinear optical microscopy"

description: Datas in the folder entitled "1720-nm mode-locked fiber laser system for CARS imaging" include both the laser system datas and imaging datas. The laser system datas include datas of seed cavity and amplifiers, such as power stability, spectrum, time-domain pulse train of the output pulses. The imaging datas show the images I got through the system.Datas in the folder entitled "1780-nm mode-locked fiber laser system for 3PM" record the datas of the laser seed cavity and amplifiers. The datas include spectrums, pulse train of the output pulses.
DOI: 10.25442/hku.27108862.v1
title: Supporting data for "1.7-μm mode-locked fiber laser for nonlinear optical microscopy"

description: Datas in the folder entitled "1720-nm mode-locked fiber laser system for CARS imaging" include both the laser system datas and imaging datas. The laser system datas include datas of seed cavity and amplifiers, such as power stability, spectrum, time-domain pulse train of the output pulses. The imaging datas show the images I got through the system.Datas in the folder entitled "1780-nm mode-locked fiber laser system for 3PM" record the datas of the laser seed cavity and amplifiers. The datas include spectrums, pulse train of the output pulses.
DOI: 10.25442/hku.27110392
title: Supporting data for "Engineering ultrafast exciton dynamics to boost organic photovoltaic performance"

description: State-of-the-art organic photovoltaic (OPV) devices are based on Y-type acceptors, with power conversion efficiencies now exceeding 20%. However, the basic structure-photophysics-performance relationship of these materials remains unclear, hindering rational material development and engineering. Here we investigate a broad range of Y-type acceptors using a combination of experimental and theoretical studies. We first show that a transient electroabsorption (TEA) signal is universal in neat Y-type acceptor films upon photoexcitation, which is caused by the formation of intermolecular charge-transfer (ICT) states in tightly packed molecular aggregates (i.e. ordered regions of the film). Tracking the TEA signal growth dynamics can monitor the migration of excitons from disordered to ordered regions in various Y-type acceptor films on the sub-picosecond timescale. Importantly, our results reveal that Y-type acceptors with moderately reduced intermolecular interaction strength can generally achieve faster exciton migration, better structural uniformity and higher device performance, thereby providing insights for future OPV material development and engineering.
DOI: 10.25442/hku.27110392.v1
title: Supporting data for "Engineering ultrafast exciton dynamics to boost organic photovoltaic performance"

description: State-of-the-art organic photovoltaic (OPV) devices are based on Y-type acceptors, with power conversion efficiencies now exceeding 20%. However, the basic structure-photophysics-performance relationship of these materials remains unclear, hindering rational material development and engineering. Here we investigate a broad range of Y-type acceptors using a combination of experimental and theoretical studies. We first show that a transient electroabsorption (TEA) signal is universal in neat Y-type acceptor films upon photoexcitation, which is caused by the formation of intermolecular charge-transfer (ICT) states in tightly packed molecular aggregates (i.e. ordered regions of the film). Tracking the TEA signal growth dynamics can monitor the migration of excitons from disordered to ordered regions in various Y-type acceptor films on the sub-picosecond timescale. Importantly, our results reveal that Y-type acceptors with moderately reduced intermolecular interaction strength can generally achieve faster exciton migration, better structural uniformity and higher device performance, thereby providing insights for future OPV material development and engineering.