cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25306195.v1
title: Supplementary Tables

description: This is the supplementary data set for the original research article titled 'Knowledge, Attitude, and Practice of Healthcare Professionals and Medical Students regarding Probiotics and Prebiotics in Lahore, Pakistan; A Cross-Sectional Study. This study aimed to assess the knowledge, attitude, and practice of healthcare professionals and medical students regarding prebiotics and probiotics in different health conditions. A total of 417 participants were included, and data was collected using a pre-formed questionnaire. The results showed that most respondents had poor knowledge and practice regarding prebiotics and probiotics. The study concluded that a lack of knowledge was the primary barrier to using pre- and probiotics. The authors suggest that educational tools like curriculum and training programs should include evidence-based information to raise awareness among healthcare professionals about their benefits and address concerns associated with their use in treating patients.
DOI: 10.6084/m9.figshare.24049779
title: An fNIRS dataset for driving risk cognition of passengers in highly automated driving scenarios

description: A total of 20 participants completed this driving simulator experiment. This study complied with the Declaration of Helsinki and was approved by the Institutional Review Board of Tsinghua University, China(Approval number: 20210102). Participants were voluntary after the task and informed consent had been explained, they also were informed that they may terminate this experiment at any time without any type of penalty, and the informed consent includes the notice that the results associated with this work might be published in academic journals or books.This dataset containsthe raw data of ΔHbOand ΔHbR, the preprocessing data of ΔHbOand ΔHbRby Homer3 and driving scenario data, and the driving scenario data is compose of the position, velocity and acceleration of ego vehicle and target vehicle (or pedestrian).They were stored in the folders of "RawfNIRSDataset", "PreprocessingfNIRSDataset", and "VehicleStatusDataset" respectively in Figshare. The data of twenty participants in same highly automated driving scenario was stored in a same folder, and the shorthand of scenario name is named as the folder name. Besides, The codes of preprocessing functions and procedures of validation mentioned in the technical validation section and a brief description(readme.docx) have been uploaded in the folder “code”in Figshare.
DOI: 10.6084/m9.figshare.24049798
title: Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

description: Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear. We detected concentration of metabolites through metabolomic analyses using UPLC-MS/MS, and the oxygen consumption rate was determined using the Seahorse Extracellular Flux analyzer. We observed that MLT effectively inhibited RCC cell growth both in vitro and in vivo. Additionally, MLT increased ROS levels, suppressed antioxidant enzyme activity, and induced apoptosis. Furthermore, MLT treatment upregulated key TCA cycle metabolites while reducing aerobic glycolysis products, leading to higher oxygen consumption rate, ATP production, and membrane potential. Moreover, MLT treatment suppressed phosphorylation of Akt, mTOR, and p70 S6 Kinase as well as the expression of HIF-1α/VEGFA in RCC cells; these effects were reversed by NAC (ROS inhibitors). Conversely, MLT synergistically inhibited cell growth with sunitinib and counteracted the Warburg effect induced by sunitinib in RCC cells. In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.
DOI: 10.6084/m9.figshare.24049798.v1
title: Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

description: Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear. We detected concentration of metabolites through metabolomic analyses using UPLC-MS/MS, and the oxygen consumption rate was determined using the Seahorse Extracellular Flux analyzer. We observed that MLT effectively inhibited RCC cell growth both in vitro and in vivo. Additionally, MLT increased ROS levels, suppressed antioxidant enzyme activity, and induced apoptosis. Furthermore, MLT treatment upregulated key TCA cycle metabolites while reducing aerobic glycolysis products, leading to higher oxygen consumption rate, ATP production, and membrane potential. Moreover, MLT treatment suppressed phosphorylation of Akt, mTOR, and p70 S6 Kinase as well as the expression of HIF-1α/VEGFA in RCC cells; these effects were reversed by NAC (ROS inhibitors). Conversely, MLT synergistically inhibited cell growth with sunitinib and counteracted the Warburg effect induced by sunitinib in RCC cells. In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.
DOI: 10.6084/m9.figshare.24574123
title: A Decorrelating and Debiasing Approach to Simultaneous Inference for High-Dimensional Confounded Models

description: Motivated by the simultaneous association analysis with the presence of latent confounders, this paper studies the large-scale hypothesis testing problem for the high-dimensional confounded linear models with both non-asymptotic and asymptotic false discovery control. Such model covers a wide range of practical settings where both the response and the predictors may be confounded. In the presence of the high-dimensional predictors and the unobservable confounders, the simultaneous inference with provable guarantees becomes highly challenging, and the unknown strong dependence among the confounded covariates makes the challenge even more pronounced. This paper first introduces a decorrelating procedure that shrinks the confounding effect and weakens the correlations among the predictors, then performs debiasing under the decorrelated design based on some biased initial estimator. Following that, an asymptotic normality result for the debiased estimator is established and standardized test statistics are then constructed. Furthermore, a simultaneous inference procedure is proposed to identify significant associations, and both the finite-sample and asymptotic false discovery bounds are provided. The non-asymptotic result is general and model-free, and is of independent interest. We also prove that, under minimal signal strength condition, all associations can be successfully detected with probability tending to one. Simulation and real data studies are carried out to evaluate the performance of the proposed approach and compare it with other competing methods.
DOI: 10.6084/m9.figshare.24574123.v1
title: A Decorrelating and Debiasing Approach to Simultaneous Inference for High-Dimensional Confounded Models

description: Motivated by the simultaneous association analysis with the presence of latent confounders, this paper studies the large-scale hypothesis testing problem for the high-dimensional confounded linear models with both non-asymptotic and asymptotic false discovery control. Such model covers a wide range of practical settings where both the response and the predictors may be confounded. In the presence of the high-dimensional predictors and the unobservable confounders, the simultaneous inference with provable guarantees becomes highly challenging, and the unknown strong dependence among the confounded covariates makes the challenge even more pronounced. This paper first introduces a decorrelating procedure that shrinks the confounding effect and weakens the correlations among the predictors, then performs debiasing under the decorrelated design based on some biased initial estimator. Following that, an asymptotic normality result for the debiased estimator is established and standardized test statistics are then constructed. Furthermore, a simultaneous inference procedure is proposed to identify significant associations, and both the finite-sample and asymptotic false discovery bounds are provided. The non-asymptotic result is general and model-free, and is of independent interest. We also prove that, under minimal signal strength condition, all associations can be successfully detected with probability tending to one. Simulation and real data studies are carried out to evaluate the performance of the proposed approach and compare it with other competing methods.
DOI: 10.6084/m9.figshare.25306198
title: 0. penaltis_clean.csv

description: database of penalty kicks in high-performance professional football
DOI: 10.5281/zenodo.8023456
title: 3D Model of the Inner lid of Butehamon, Museo Egizio, Turin (Inv. n. Cat. 2237; CGT10102a)

description: 3D model of the "yellow" coffin's inner lid of the Royal Scribe of the Necropolis Butehamon (Museo Egizio, Turin, Cat. 2237, CGT 10102.a)

The dataset contains:



zip file with the photographs and the 3D model generated with the software Agisoft Metashape Professional 1.8.3;

.png file with the orthophtgraph of the coffin textured and not textured

.psd file with the overlapped orthophtgraphs of the coffin textured and not textured (right, front and left sides)

Exported Report of 3D model

.pdn file with the verlapped layers (orthophotographs textured and not textured, drawings and points) generated with the open source paint. net


The photogrammetry is part of Faces Revealed Project. The project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 895130

 

If you publish material based on datasets contained in this archive, then, in your acknowledgements, please cite the original source, referring to it through the following DOI: 10.5281/zenodo.8023456
DOI: 10.6084/m9.figshare.11466981
title: Sedimentary response to the non-synchronous closure of Paleo-Asian Ocean: evidence from U-Pb ages and Hf isotopic compositions of detrital zircons from the Linxi Formation, NE China

description: The Linxi Formation is widely deposited in eastern Inner Mongolia (NE China), especially along northern parts of the Solonker-Xar Moron Suture (SXMS) in the eastern Central Asian Orogenic Belt, yet its depositional age and provenance remain ambiguous. We studied the petrography, geochronology, and Hf isotopes of two sandstone samples from this formation, and estimated the depositional age and the provenance of the Linxi Formation, and further constrained the evolution of the Paleo-Asian Ocean (PAO). Based on detailed field observations and measurements, we. Zircons from rocks of the Linxi Formation are mainly composed of detrital zircons of magmatic origin. The determined ages of detrital zircons range from 233 ± 2 Ma to 1365 ± 14 Ma, and indicate that the provenance of the Linxi Formation experienced at least four tectonic-thermal events between 1365 and 233 Ma: Neoproterozoic (ca. 1365–543 Ma), Early Palaeozoic (ca. 512–426 Ma), Late Palaeozoic (ca. 418–251 Ma), and Early Mesozoic (ca. 249–233 Ma). The youngest detrital zircon, with a U-Pb age of 233 ± 2 Ma, defines the maximum depositional age of the Linxi Formation. The ε<sub>Hf</sub> (t) values of dated zircons from the sandstone samples have a large range (−7.8–15.0). The four dominant age groups and the range in ε<sub>Hf</sub> (t) values are widely found in the Xing’an Block and Songnen-Zhangguangcai Range, which imply that the source of the Linxi Formation had an affinity with northeastern China. These data together with previous geochronological data (from west to east along the SXMS) on the crystallization and depositional ages of detrital zircon suggest that the Linxi Formation was deposited in different tectonic settings: convergent, collisional, and extensional. This study provides further evidence and constraints for the non-synchronous closure of the PAO.
DOI: 10.6084/m9.figshare.11466981.v1
title: Sedimentary response to the non-synchronous closure of Paleo-Asian Ocean: evidence from U-Pb ages and Hf isotopic compositions of detrital zircons from the Linxi Formation, NE China

description: The Linxi Formation is widely deposited in eastern Inner Mongolia (NE China), especially along northern parts of the Solonker-Xar Moron Suture (SXMS) in the eastern Central Asian Orogenic Belt, yet its depositional age and provenance remain ambiguous. We studied the petrography, geochronology, and Hf isotopes of two sandstone samples from this formation, and estimated the depositional age and the provenance of the Linxi Formation, and further constrained the evolution of the Paleo-Asian Ocean (PAO). Based on detailed field observations and measurements, we. Zircons from rocks of the Linxi Formation are mainly composed of detrital zircons of magmatic origin. The determined ages of detrital zircons range from 233 ± 2 Ma to 1365 ± 14 Ma, and indicate that the provenance of the Linxi Formation experienced at least four tectonic-thermal events between 1365 and 233 Ma: Neoproterozoic (ca. 1365–543 Ma), Early Palaeozoic (ca. 512–426 Ma), Late Palaeozoic (ca. 418–251 Ma), and Early Mesozoic (ca. 249–233 Ma). The youngest detrital zircon, with a U-Pb age of 233 ± 2 Ma, defines the maximum depositional age of the Linxi Formation. The ε<sub>Hf</sub> (t) values of dated zircons from the sandstone samples have a large range (−7.8–15.0). The four dominant age groups and the range in ε<sub>Hf</sub> (t) values are widely found in the Xing’an Block and Songnen-Zhangguangcai Range, which imply that the source of the Linxi Formation had an affinity with northeastern China. These data together with previous geochronological data (from west to east along the SXMS) on the crystallization and depositional ages of detrital zircon suggest that the Linxi Formation was deposited in different tectonic settings: convergent, collisional, and extensional. This study provides further evidence and constraints for the non-synchronous closure of the PAO.
DOI: 10.6084/m9.figshare.21428455
title: miR-140-3p/usp36 axis mediates ubiquitination to regulate PKM2 and suppressed the malignant biological behavior of breast cancer through Warburg effect

description: Breast cancer is a phenomenon in which breast epithelial cells proliferate out of control under the action of various carcinogenic factors. However, the role of USP36 in breast cancer is unknown. We analyzed the expression of USP36 in breast cancer and its association with poor prognosis in breast cancer patients. The effect of USP36 on malignant biological behavior of breast cancer was verified by cell functional experiments. The upstream regulatory mechanism of USP36 was analyzed by Western blot and quantitative RT-qPCR. The influence of USP36 on the Warburg effect of breast cancer was analyzed by detecting the metabolism of cellular energy substances. We found that USP36 is highly expressed in breast tumor tissues and breast cancer cell lines. High expression of USP36 predicts poor prognosis in patients with breast cancer. Effectively reducing the expression of USP36 can significantly inhibit the proliferation, invasion and migration of breast cancer cells, and promote the apoptosis of breast cancer cells. Meanwhile, inhibiting the expression of USP36 can significantly inhibit the production of ATP, lactate, pyruvate and glucose uptake in breast cancer cells. miR-140-3p is an upstream regulator of USP36, which can partially reverse the regulatory effect of USP36 on breast cancer cells. Importantly, USP36 regulates the expression of PKM2 through ubiquitination, which plays a role in regulating the Warburg effect. We confirmed that miR-140-3p regulates the expression of USP36, which mediates ubiquitination and regulates the expression of PKM2, and regulates the malignant biological behavior of breast cancer through the energy metabolism process.
DOI: 10.6084/m9.figshare.21428455.v1
title: miR-140-3p/usp36 axis mediates ubiquitination to regulate PKM2 and suppressed the malignant biological behavior of breast cancer through Warburg effect

description: Breast cancer is a phenomenon in which breast epithelial cells proliferate out of control under the action of various carcinogenic factors. However, the role of USP36 in breast cancer is unknown. We analyzed the expression of USP36 in breast cancer and its association with poor prognosis in breast cancer patients. The effect of USP36 on malignant biological behavior of breast cancer was verified by cell functional experiments. The upstream regulatory mechanism of USP36 was analyzed by Western blot and quantitative RT-qPCR. The influence of USP36 on the Warburg effect of breast cancer was analyzed by detecting the metabolism of cellular energy substances. We found that USP36 is highly expressed in breast tumor tissues and breast cancer cell lines. High expression of USP36 predicts poor prognosis in patients with breast cancer. Effectively reducing the expression of USP36 can significantly inhibit the proliferation, invasion and migration of breast cancer cells, and promote the apoptosis of breast cancer cells. Meanwhile, inhibiting the expression of USP36 can significantly inhibit the production of ATP, lactate, pyruvate and glucose uptake in breast cancer cells. miR-140-3p is an upstream regulator of USP36, which can partially reverse the regulatory effect of USP36 on breast cancer cells. Importantly, USP36 regulates the expression of PKM2 through ubiquitination, which plays a role in regulating the Warburg effect. We confirmed that miR-140-3p regulates the expression of USP36, which mediates ubiquitination and regulates the expression of PKM2, and regulates the malignant biological behavior of breast cancer through the energy metabolism process.
DOI: 10.5281/zenodo.8025245
title: 3D Model of the Mummy board of Butehamon, Museo Egizio, Turin (Inv. n. Cat. 2237; CGT10103)

description: 3D model of the "yellow" coffin's mummy board of the Royal Scribe of the Necropolis Butehamon (Museo Egizio, Turin, Cat. 2237, CGT 10103).

The dataset contains:



zip file with the photographs and the 3D model generated with the software Agisoft Metashape 1.8.3;

.png file with the orthophtgraph of the coffin textured and not textured

.psd file with the overlapped orthophtgraphs of the coffin textured and not textured (right, front and left sides)

Exported Report of 3D model

.pdn file with the verlapped layers (orthophotographs textured and not textured, drawings and points) generated with the open source paint. net


The dataset is part of the results of the  Faces Revealed Project. The project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 895130

 

If you publish material based on datasets contained in this archive, then, in your acknowledgements, please cite the original source, referring to it through the following DOI: 10.5281/zenodo.8025245
DOI: 10.57745/zifirn
title: vulnerabilite_agri_84.zip

description: :unav
DOI: 10.6084/m9.figshare.21952833
title: The complete chloroplast genome and phylogenetic analysis of <i>Christella dentata</i> (Forssk.) Brownsey & Jermy (Thelypteridaceae)

description: <i>Christella dentata</i> (Forssk.) Brownsey & Jermy (Thelypteridaceae) is endemic to the tropical and subtropical regions of Africa, Asia, and Asia Pacific. In this study, the complete chloroplast genome sequence of <i>C. dentata</i> was assembled using next-generation sequencing data. The complete chloroplast genome was 151,662 bp in length and had a typical quadripartite structure, which consisted of a small single-copy region (21,776 bp) and a large single-copy region (82,624 bp) that were separated by a pair of inverted repeats (23,631 bp each). A total of 131 genes were predicted, including 89 protein coding (CDS), 34 tRNA, and eight rRNA genes. The overall GC content of the chloroplast genome was 42.48%. Based on the concatenated shared unique CDS sequence dataset, phylogenetic analysis using both the maximum-likelihood and the Bayesian inference methods revealed that <i>C. dentata</i> is placed within Thelypteridaceae and is closely related to <i>Christella appendiculata</i>. Such genetic information would be useful for studies on the evolution pattern in ferns. The availability of chloroplast genome sequence for the species also paves the way to resolving the complicated relationship among members of <i>Christella</i>.
DOI: 10.6084/m9.figshare.21952833.v1
title: The complete chloroplast genome and phylogenetic analysis of <i>Christella dentata</i> (Forssk.) Brownsey & Jermy (Thelypteridaceae)

description: <i>Christella dentata</i> (Forssk.) Brownsey & Jermy (Thelypteridaceae) is endemic to the tropical and subtropical regions of Africa, Asia, and Asia Pacific. In this study, the complete chloroplast genome sequence of <i>C. dentata</i> was assembled using next-generation sequencing data. The complete chloroplast genome was 151,662 bp in length and had a typical quadripartite structure, which consisted of a small single-copy region (21,776 bp) and a large single-copy region (82,624 bp) that were separated by a pair of inverted repeats (23,631 bp each). A total of 131 genes were predicted, including 89 protein coding (CDS), 34 tRNA, and eight rRNA genes. The overall GC content of the chloroplast genome was 42.48%. Based on the concatenated shared unique CDS sequence dataset, phylogenetic analysis using both the maximum-likelihood and the Bayesian inference methods revealed that <i>C. dentata</i> is placed within Thelypteridaceae and is closely related to <i>Christella appendiculata</i>. Such genetic information would be useful for studies on the evolution pattern in ferns. The availability of chloroplast genome sequence for the species also paves the way to resolving the complicated relationship among members of <i>Christella</i>.
DOI: 10.15468/ynfgay
title: Parc éolien de l'Epine Amanty - L'Epine Amanty - 2021 - Prénuptial

description: Suivi migration par point d'observation en milieux agricole et de lisière.
DOI: 10.15468/afqk6s
title: Parc éolien Col de la Fageole-DEPOBIO_Coren_annee_2021_2022-12-12_IPA

description: COREN 2021 Processus de collecte IPA
DOI: 10.6084/m9.figshare.7797137
title: Raw data from Protein content and amino acids profile in 10 cultivars of ginkgo (<i>Ginkgo biloba</i> L.) nut from China

description: The raw values of N content and amino acid concentration for each sample of ginkgo nuts, obtained using automatic element analyzer and amino acid analyzer, respectively.
DOI: 10.6084/m9.figshare.7797137.v1
title: Raw data from Protein content and amino acids profile in 10 cultivars of ginkgo (<i>Ginkgo biloba</i> L.) nut from China

description: The raw values of N content and amino acid concentration for each sample of ginkgo nuts, obtained using automatic element analyzer and amino acid analyzer, respectively.