cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.25771737.v1
title: Supporting data for "Parallel engineering and activity profiling of base editor system"

description: Advancement in base editors’ development enables all possible base-pair conversions. Currently, laborious one-by-one testing has been used to select or engineer the optimal variant for inducing a specific base substitution with maximal efficiency yet minimal undesired effects. This thesis work presents a high throughput activity profiling platform to streamline the evaluation process by enabling simultaneous performance assessment of a diverse pool of base editor variant in scale. This platform generates single-nucleotide resolution readouts, allowing quantitative measurements of each variant’s performance within a cytosine base editor library, including editing efficiency, substrate motif preference, positional biases and haplotype analysis. Undesired outcomes such as impure edits, indels and noncanonical base conversions are also uncovered during the process. This work further demonstrates the discovery power of this platform via a sgRNA scaffold library, identifying two scaffold variants, SV48 and SV240, that enhance base editing efficiency while maintaining an acceptable rate of inducing undesired edits. This work also explores the potential of integrating machine learning techniques to broaden the scope of engineering with the platform, which further lowers the experimental burden. By introducing slight modifications, this platform can be adapted for parallel engineering and screening of other precise genome editors such as adenine base editors and prime editors. With the continuously expanding repertoire of genome editing tools, this platform addresses the pressing need for scalable, unbiased, and rapid benchmarking of engineered variants. This would also accelerate the development of next-generation precise genome editors and pave the way for specialised editor design by optimising, profiling, and selecting the most suitable tools for specific applications.
DOI: 10.25442/hku.25780836
title: Supporting data for "Systemic Immune Biomarkers Reflect the Local Tumor Immune Environment in Recurrent/Metastatic Nasopharyngeal Carcinoma"

description: Changes within the tumor immune microenvironment (TME) are often reflected in peripheral immune populations. Therein, development of biomarkers based on peripheral immune population phenotypes offers an opportunity to capture intratumoral dynamics. Here in we report development of a peripheral immune-based biomarker approach for Nasopharyngeal Carcinoma (R/M NPC). We focused on quantitating levels of peripheral CX3CR1+ CD8+ T cells with high clonal similarity to tumor-infiltrating counterparts and expression of the exclusive CX3CR1 ligand CX3CL1 in NPC models. We found that NPC tumor cell expression of CX3CL1 impacted the stemness and immunoregulatory polarization of CX3CR1+CD8+ T cells while also promoting their infiltration into the TME. Analysis of peripheral blood collected from 38 R/M NPC patients treated a bifunctional fusion protein bintrafusp alfa demonstrated that responders retained stable immune profiles, while non-responders experienced a decrease in CX3CR1+CD8+ T cells and an increase in monocytic myeloid derived suppressor cells (M-MDSCs). Additionally, we observed a significant correlation between tissue PD-L1 expression status and levels of soluble immune checkpoints. These findings suggest that CX3CR1+CD8+ T cells may serve as a potential predictive biomarker for immunotherapeutic outcomes in NPC.
DOI: 10.25442/hku.25780836.v1
title: Supporting data for "Systemic Immune Biomarkers Reflect the Local Tumor Immune Environment in Recurrent/Metastatic Nasopharyngeal Carcinoma"

description: Changes within the tumor immune microenvironment (TME) are often reflected in peripheral immune populations. Therein, development of biomarkers based on peripheral immune population phenotypes offers an opportunity to capture intratumoral dynamics. Here in we report development of a peripheral immune-based biomarker approach for Nasopharyngeal Carcinoma (R/M NPC). We focused on quantitating levels of peripheral CX3CR1+ CD8+ T cells with high clonal similarity to tumor-infiltrating counterparts and expression of the exclusive CX3CR1 ligand CX3CL1 in NPC models. We found that NPC tumor cell expression of CX3CL1 impacted the stemness and immunoregulatory polarization of CX3CR1+CD8+ T cells while also promoting their infiltration into the TME. Analysis of peripheral blood collected from 38 R/M NPC patients treated a bifunctional fusion protein bintrafusp alfa demonstrated that responders retained stable immune profiles, while non-responders experienced a decrease in CX3CR1+CD8+ T cells and an increase in monocytic myeloid derived suppressor cells (M-MDSCs). Additionally, we observed a significant correlation between tissue PD-L1 expression status and levels of soluble immune checkpoints. These findings suggest that CX3CR1+CD8+ T cells may serve as a potential predictive biomarker for immunotherapeutic outcomes in NPC.
DOI: 10.15468/dl.p2hszv
title: Occurrence Download

description: A dataset containing 215 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Podocerus brasiliensis (Dana, 1853))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 215 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025477-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gqnw8p
title: Occurrence Download

description: A dataset containing 298 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Callosobruchus maculatus (Fabricius, 1775))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 298 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025478-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yn643z
title: Occurrence Download

description: A dataset containing 954 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN.11_1",
 "TaxonKey is Aves",
 "Year 2014-2015"
 ]
}

 The dataset includes 954 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025479-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4n3n23
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "GbifRegion is Latin America and the Caribbean",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Aderus Stephens, 1829"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025481-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9vq687
title: Occurrence Download

description: A dataset containing 886 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Agasicles hygrophila Selman & Vogt, 1971)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 886 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025480-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.efza4g
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Leucothoe micronesiae J.L.Barnard, 1965)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 22 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025482-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ts2gzm
title: Occurrence Download

description: A dataset containing 596 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Chrysolina quadrigemina (Suffrian, 1851))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 596 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025483-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.acqa4p
title: Occurrence Download

description: A dataset containing 49 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Paraleucothoe flindersi (Stebbing, 1888))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 49 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025484-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jhspj5
title: Occurrence Download

description: A dataset containing 75 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Chelura terebrans Philippi, 1839)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 75 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025485-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z7vkuf
title: Occurrence Download

description: A dataset containing 6957752 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Chinese Taipei)",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 6957752 records from 916 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025460-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bzjswj
title: Occurrence Download

description: A dataset containing 4726 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Chrysolina hyperici (Forster, 1771))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4726 records from 269 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025486-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.daa32z
title: Occurrence Download

description: A dataset containing 772 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Caprella equilibra Say, 1818)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 772 records from 84 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025487-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dz2kjx
title: Occurrence Download

description: A dataset containing 284 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Algarobius prosopis (J.L.LeConte, 1858))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 284 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025489-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c4duws
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Caprella drepanochir Mayer, 1890)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 21 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025490-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.48cc25
title: Occurrence Download

description: A dataset containing 954 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN.11_1",
 "TaxonKey is Aves",
 "Year 2014-2015"
 ]
}

 The dataset includes 954 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025492-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7xtnxj
title: Occurrence Download

description: A dataset containing 221 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Algarobius bottimeri Kingsolver, 1972)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 221 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025493-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3w7fj3
title: Occurrence Download

description: A dataset containing 112 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ditylenchus dipsaci (Kühn, 1857) Filipjev, 1936"
 ]
}

 The dataset includes 112 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025494-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ey42xu
title: Occurrence Download

description: A dataset containing 1596 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Caprella mutica Schurin, 1935)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1596 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025495-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5gx4557c
title: MassIVE MSV000094812 - Gut microbiota synthetic community with bile acids
title: Q Exactive - with chromatographic separation on a Phenomenex polar C18 column
DOI: 10.15468/dl.9mam9z
title: Occurrence Download

description: A dataset containing 2151 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Neogalerucella calmariensis (Linnaeus, 1767))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2151 records from 151 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025496-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.89q9gg
title: Occurrence Download

description: A dataset containing 147 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Centaurea atropurpurea Olivier"
 ]
}

 The dataset includes 147 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0128804-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.22zdnm
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Gentianella stoliczka (Kurz ex C.B.Clarke) Holub"
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0218494-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j4gzqe
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Centaurea aphrodisea Boiss."
 ]
}

 The dataset includes 22 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0128749-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7kcvzs
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Bradypus pygmaeus Anderson & Handley, 2001"
 ]
}

 The dataset includes 14 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003880-190813142620410/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eggxcv
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rhaponticoides androssovii (Iljin) Negaresh"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0128739-230224095556074/datasets/export for details.
DOI: 10.15468/dl.br85av
title: Occurrence Download

description: A dataset containing 238 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chrysosplenium nudicaule Bunge"
 ]
}

 The dataset includes 238 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0199090-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r8mjcr
title: Occurrence Download

description: A dataset containing 136107 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((5.05783 43.09662,5.71701 43.09662,5.71701 43.87665,5.05783 43.87665,5.05783 43.09662))",
 "TaxonKey is Arthropoda"
 ]
}

 The dataset includes 136107 records from 316 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0218505-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hqe5qw
title: Occurrence Download

description: A dataset containing 522 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cinclodes palliatus (Tschudi, 1844)"
 ]
}

 The dataset includes 522 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0069512-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bv586b
title: Occurrence Download

description: A dataset containing 163923 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Sus scrofa Linnaeus, 1758",
 "Year 2000-2022"
 ]
}

 The dataset includes 163923 records from 1205 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0422094-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.v482fd
title: Occurrence Download

description: A dataset containing 174 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Centaurea ambigua Guss."
 ]
}

 The dataset includes 174 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0128729-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eg95zx
title: Occurrence Download

description: A dataset containing 23 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "TaxonKey is Cuminum cyminum"
 ]
}

 The dataset includes 23 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0042223-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gtyx1y
title: Occurrence Download

description: A dataset containing 181 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Schizothorax richardsonii (Gray, 1832)"
 ]
}

 The dataset includes 181 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021264-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6vtnh7
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Helicia saurauioides Sleumer"
 ]
}

 The dataset includes 5 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017507-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j8nq62
title: Occurrence Download

description: A dataset containing 329512 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Convolvulus arvensis L."
 ]
}

 The dataset includes 329512 records from 1007 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0205058-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b72qtn
title: Occurrence Download

description: A dataset containing 94 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Human Observation"
 ]
 },
 "Country is Mexico",
 "Year 2005-2019",
 "HasCoordinate is true",
 "TaxonKey is Pinus leiophylla Schiede ex Schltdl. & Cham."
 ]
}

 The dataset includes 94 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021264-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.suvm5a
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Lygodactylus graniticolus Jacobsen, 1992"
 ]
}

 The dataset includes 18 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080482-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6zk4lb
title: Occurrence Download

description: A dataset containing 218 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Oxalis tenuifolia Jacq."
 ]
}

 The dataset includes 218 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004464-200127171203522/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.