cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5522/04/27161412.v1
title: Raw Data for RSC Nanoscale article "Multivalent nanobody engineering for enhanced physisorption and functional display on gold nanoparticles"

description: Raw data for the RSC Nanoscale article entitled: "Multivalent nanobody engineering for enhanced physisorption and functional display on gold nanoparticles" 2024. We demonstrate the value of using multivalent nanobody formats in improving the binding characteristics of gold nanoparticles in a lateral flow assay format and show the variation observed for different valency formats from 1-3. The nanobodies used are binders for the SARS-CoV-2 RBD as a model system. This archive contains dynamic light scattering data on nanoparticles with various nanobody protein coronas, bilayer interferometry kinetic data for engineered nanobodies, Uv-vis data on protein adsorption and aggregation studies, and lateral flow assay images for dose response studies. The data is in raw format and processed.
DOI: 10.6084/m9.figshare.27186066
title: <b>Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism: A Prospective Clinical Study</b>

description: Supplementary Materials of "<b>Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism: A Prospective Clinical Study</b>"
DOI: 10.6084/m9.figshare.27186066.v1
title: <b>Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism: A Prospective Clinical Study</b>

description: Supplementary Materials of "<b>Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism: A Prospective Clinical Study</b>"
DOI: 10.15468/dl.jfzezj
title: Occurrence Download

description: A dataset containing 47 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "DatasetKey" : [
 "is Global database of alien macrofungi"
 ]
 }
 },
 "TaxonKey is Tubercularia minor Link"
 ]
}

 The dataset includes 47 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002423-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26521046
title: Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications

description: <b>Aim & Objective:</b> This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy. <b>Materials & Methods:</b> The nanoformulation was optimized via Box-Behnken Design (BBD), with method validation adhering to US-FDA guidelines. <b>Results:</b> Multiple reaction monitoring transitions for PTX, BTZ and internal standard were m/z 855.80→286.60, 366.80→226.00 and 179.80→110.00, respectively. Elution done on C18 Luna column with 0.1% FA in MeOH:10 mM ammonium acetate. The size of nanoformulation was 133.9 ± 1.97 nm, PDI 0.19 ± 0.01 and zeta potential -19.20 ± 1.36 mV. Pharmacokinetics showed higher C<sub>max</sub> for PTX-BTZ-NE (313.75 ± 10.71 ng/ml PTX, 11.92 ± 0.53 ng/ml BTZ) versus free PTX-BTZ (104 ± 13.06 ng/ml PTX, 1.9 ± 0.08 ng/ml BTZ). <b>Conclusion:</b> Future findings will contribute to the treatment of breast cancer using PTX and BTZ. The importance of paclitaxel (PTX) and bortezomib (BTZ) in combination with chemotherapy is demonstrated by recently published studies. An obstacle to measuring the results of translational research is the lack of an analytical or bioanalytical approach for simultaneously estimating PTX and BTZ. A gap in the scientific literature has been filled by the development and validation of an LC-MS/MS method for the co-estimation or simultaneous measurement of PTX and BTZ. Both moieties were resolved in a Phenomenex Luna (C18), (7.5 × 4.6 mm, 3μ) column with a 0.1% FA in MeOH:10 mM ammonium acetate, 80:20 (% v/v) mobile phase at 0.6 ml/min flow rate. According to the US-FDA, the developed method was validated in female Sprague–Dawley rats plasma for different characteristics, such as linearity, precision and accuracy, LLOQ and stability studies. The oral P.K profile of PTX and BTZ co-loaded in a nanoformulation has been investigated in young female Sprague–Dawley rats to support the applicability of the established LC-MS/MS methodology. With an LLOQ of 1.0 ng/ml for each drug and a run time of 6.0 min, the calibration curve was found linear for the 1–600 ng/ml concentration range. The proposed LC-MS/MS method was confirmed to be repeatable, precise and accurate. The developed LC-MS/MS method was successfully illustrated for the co-estimation or simultaneous estimation of both drugs in rat plasma to generate an oral P.K profile. US-FDA Guidance of Industry and Bioanalytical Method Validation criteria was followed for the co-estimation of PTX and BTZ and was applied to nanoformulation development and bioanalytical investigations.
DOI: 10.6084/m9.figshare.26521056
title: Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia–reperfusion injury

description: <b>Aim:</b> To target the reactive oxygen species (ROS) accumulation and renal tubular epithelial cell (rTEC) death in renal ischemia–reperfusion injury (IRI), we constructed a nanoparticle that offers ROS scavenging and rTEC-death inhibition: mesoporous zinc–tannic acid nanozyme (ZnTA). <b>Materials & methods:</b> After successfully constructing ZnTA, we proceeded to examine its effect on ROS accumulation, cellular ferroptosis and apoptosis, as well as injury severity. <b>Results:</b> Malondialdehyde, Fe<sup>2+</sup> amounts and 4-HNE staining demonstrated that ZnTA effectively attenuated rTEC ferroptosis. TUNEL staining confirmed that Zn<sup>2+</sup> carried by ZnTA could effectively inhibit caspase 3 and caspase 9, mitigating apoptosis. Finally, it reduced renal IRI through the synergistic effect of ROS scavenging and cell-death inhibition. <b>Conclusion:</b> This study is expected to provide a paradigm for a combined therapeutic strategy for renal IRI. In this study, zinc–tannic acid nanozyme (ZnTA) was synthesized using natural plant polyphenol tannic acid. This study explored the morphological characteristics of ZnTA in detail. ZnTA has excellent reactive oxygen species scavenging effect. ZnTA was observed to effectively inhibit ferroptosis in both <i>in vitro</i> and <i>in vivo</i> experiments. The morphological characteristics of mitochondria after ZnTA treatment were examined using electron microscopy. Zn<sup>2+</sup> in ZnTA inhibited the expression of caspase 3 and 9. Apoptosis inhibition was observed after ZnTA treatment. ZnTA can effectively alleviate renal IRI.
DOI: 10.6084/m9.figshare.26521056.v1
title: Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia–reperfusion injury

description: <b>Aim:</b> To target the reactive oxygen species (ROS) accumulation and renal tubular epithelial cell (rTEC) death in renal ischemia–reperfusion injury (IRI), we constructed a nanoparticle that offers ROS scavenging and rTEC-death inhibition: mesoporous zinc–tannic acid nanozyme (ZnTA). <b>Materials & methods:</b> After successfully constructing ZnTA, we proceeded to examine its effect on ROS accumulation, cellular ferroptosis and apoptosis, as well as injury severity. <b>Results:</b> Malondialdehyde, Fe<sup>2+</sup> amounts and 4-HNE staining demonstrated that ZnTA effectively attenuated rTEC ferroptosis. TUNEL staining confirmed that Zn<sup>2+</sup> carried by ZnTA could effectively inhibit caspase 3 and caspase 9, mitigating apoptosis. Finally, it reduced renal IRI through the synergistic effect of ROS scavenging and cell-death inhibition. <b>Conclusion:</b> This study is expected to provide a paradigm for a combined therapeutic strategy for renal IRI. In this study, zinc–tannic acid nanozyme (ZnTA) was synthesized using natural plant polyphenol tannic acid. This study explored the morphological characteristics of ZnTA in detail. ZnTA has excellent reactive oxygen species scavenging effect. ZnTA was observed to effectively inhibit ferroptosis in both <i>in vitro</i> and <i>in vivo</i> experiments. The morphological characteristics of mitochondria after ZnTA treatment were examined using electron microscopy. Zn<sup>2+</sup> in ZnTA inhibited the expression of caspase 3 and 9. Apoptosis inhibition was observed after ZnTA treatment. ZnTA can effectively alleviate renal IRI.
DOI: 10.6084/m9.figshare.26575477.v1
title: The effects of conjugating anti-MUC1 aptamers on gold nanobipyramids and nanostars for photothermal cancer ablation

description: <b>Aim:</b> To ascertain the impact of shape and surface modification of anisotropic nanoparticles on the toxicity and photothermal efficiency toward cancerous cell lines. <b>Methods:</b> Gold nanobipyramids and nanostars surface modified with MUC1 aptamer were used in the current study to explore the toxicity and photothermal efficiency on MCF7 breast cancer cell lines via MTT assay. <b>Results:</b> Surface functionalization with MUC1 aptamer showed significant reduction in % cytotoxicity and increase in % specific internalization of nanostructures into MCF7 cell lines. Further, the photothermal studies accomplished at IC<sub>50</sub> concentration for 6 h of treatment and laser exposure for 15 min reported that aptamer-conjugated nanobipyramids were more effective and specific toward MCF7 cell lines than aptamer-conjugated nanostars. <b>Conclusion:</b> This work establishes a platform for the development of tailored photoablation based gold nanostructures for <i>in vivo</i> studies. The investigation on cytotoxic effects and photothermal efficiency of anisotropic spiked gold nanostructures are requisite. Gold Nanostars (GNS), nanobipyramids (GNB) possess exceptional tip-enhanced plasmonic characteristics. GNB and GNS were synthesized and surface modified with MUC1 aptamer. GNB and GNS exhibited photothermal conversion efficiency of 14.5 and 14.1%, respectively. GNB and GNS are much less cytotoxic after aptamer conjugation. Compared with aptamer-GNS, aptamer-GNB exhibited higher selective cellular internalization toward MCF7 cell lines. Photoablation studies revealed that MCF7 cell lines were more severely damaged by aptamer-GNB than by aptamer-GNS.
DOI: 10.6084/m9.figshare.26521046.v1
title: Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications

description: <b>Aim & Objective:</b> This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy. <b>Materials & Methods:</b> The nanoformulation was optimized via Box-Behnken Design (BBD), with method validation adhering to US-FDA guidelines. <b>Results:</b> Multiple reaction monitoring transitions for PTX, BTZ and internal standard were m/z 855.80→286.60, 366.80→226.00 and 179.80→110.00, respectively. Elution done on C18 Luna column with 0.1% FA in MeOH:10 mM ammonium acetate. The size of nanoformulation was 133.9 ± 1.97 nm, PDI 0.19 ± 0.01 and zeta potential -19.20 ± 1.36 mV. Pharmacokinetics showed higher C<sub>max</sub> for PTX-BTZ-NE (313.75 ± 10.71 ng/ml PTX, 11.92 ± 0.53 ng/ml BTZ) versus free PTX-BTZ (104 ± 13.06 ng/ml PTX, 1.9 ± 0.08 ng/ml BTZ). <b>Conclusion:</b> Future findings will contribute to the treatment of breast cancer using PTX and BTZ. The importance of paclitaxel (PTX) and bortezomib (BTZ) in combination with chemotherapy is demonstrated by recently published studies. An obstacle to measuring the results of translational research is the lack of an analytical or bioanalytical approach for simultaneously estimating PTX and BTZ. A gap in the scientific literature has been filled by the development and validation of an LC-MS/MS method for the co-estimation or simultaneous measurement of PTX and BTZ. Both moieties were resolved in a Phenomenex Luna (C18), (7.5 × 4.6 mm, 3μ) column with a 0.1% FA in MeOH:10 mM ammonium acetate, 80:20 (% v/v) mobile phase at 0.6 ml/min flow rate. According to the US-FDA, the developed method was validated in female Sprague–Dawley rats plasma for different characteristics, such as linearity, precision and accuracy, LLOQ and stability studies. The oral P.K profile of PTX and BTZ co-loaded in a nanoformulation has been investigated in young female Sprague–Dawley rats to support the applicability of the established LC-MS/MS methodology. With an LLOQ of 1.0 ng/ml for each drug and a run time of 6.0 min, the calibration curve was found linear for the 1–600 ng/ml concentration range. The proposed LC-MS/MS method was confirmed to be repeatable, precise and accurate. The developed LC-MS/MS method was successfully illustrated for the co-estimation or simultaneous estimation of both drugs in rat plasma to generate an oral P.K profile. US-FDA Guidance of Industry and Bioanalytical Method Validation criteria was followed for the co-estimation of PTX and BTZ and was applied to nanoformulation development and bioanalytical investigations.
DOI: 10.6084/m9.figshare.26521046.v2
title: Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications

description: <b>Aim & Objective:</b> This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy. <b>Materials & Methods:</b> The nanoformulation was optimized via Box-Behnken Design (BBD), with method validation adhering to US-FDA guidelines. <b>Results:</b> Multiple reaction monitoring transitions for PTX, BTZ and internal standard were m/z 855.80→286.60, 366.80→226.00 and 179.80→110.00, respectively. Elution done on C18 Luna column with 0.1% FA in MeOH:10 mM ammonium acetate. The size of nanoformulation was 133.9 ± 1.97 nm, PDI 0.19 ± 0.01 and zeta potential -19.20 ± 1.36 mV. Pharmacokinetics showed higher C<sub>max</sub> for PTX-BTZ-NE (313.75 ± 10.71 ng/ml PTX, 11.92 ± 0.53 ng/ml BTZ) versus free PTX-BTZ (104 ± 13.06 ng/ml PTX, 1.9 ± 0.08 ng/ml BTZ). <b>Conclusion:</b> Future findings will contribute to the treatment of breast cancer using PTX and BTZ. The importance of paclitaxel (PTX) and bortezomib (BTZ) in combination with chemotherapy is demonstrated by recently published studies. An obstacle to measuring the results of translational research is the lack of an analytical or bioanalytical approach for simultaneously estimating PTX and BTZ. A gap in the scientific literature has been filled by the development and validation of an LC-MS/MS method for the co-estimation or simultaneous measurement of PTX and BTZ. Both moieties were resolved in a Phenomenex Luna (C18), (7.5 × 4.6 mm, 3μ) column with a 0.1% FA in MeOH:10 mM ammonium acetate, 80:20 (% v/v) mobile phase at 0.6 ml/min flow rate. According to the US-FDA, the developed method was validated in female Sprague–Dawley rats plasma for different characteristics, such as linearity, precision and accuracy, LLOQ and stability studies. The oral P.K profile of PTX and BTZ co-loaded in a nanoformulation has been investigated in young female Sprague–Dawley rats to support the applicability of the established LC-MS/MS methodology. With an LLOQ of 1.0 ng/ml for each drug and a run time of 6.0 min, the calibration curve was found linear for the 1–600 ng/ml concentration range. The proposed LC-MS/MS method was confirmed to be repeatable, precise and accurate. The developed LC-MS/MS method was successfully illustrated for the co-estimation or simultaneous estimation of both drugs in rat plasma to generate an oral P.K profile. US-FDA Guidance of Industry and Bioanalytical Method Validation criteria was followed for the co-estimation of PTX and BTZ and was applied to nanoformulation development and bioanalytical investigations.
DOI: 10.6084/m9.figshare.26575477
title: The effects of conjugating anti-MUC1 aptamers on gold nanobipyramids and nanostars for photothermal cancer ablation

description: <b>Aim:</b> To ascertain the impact of shape and surface modification of anisotropic nanoparticles on the toxicity and photothermal efficiency toward cancerous cell lines. <b>Methods:</b> Gold nanobipyramids and nanostars surface modified with MUC1 aptamer were used in the current study to explore the toxicity and photothermal efficiency on MCF7 breast cancer cell lines via MTT assay. <b>Results:</b> Surface functionalization with MUC1 aptamer showed significant reduction in % cytotoxicity and increase in % specific internalization of nanostructures into MCF7 cell lines. Further, the photothermal studies accomplished at IC<sub>50</sub> concentration for 6 h of treatment and laser exposure for 15 min reported that aptamer-conjugated nanobipyramids were more effective and specific toward MCF7 cell lines than aptamer-conjugated nanostars. <b>Conclusion:</b> This work establishes a platform for the development of tailored photoablation based gold nanostructures for <i>in vivo</i> studies. The investigation on cytotoxic effects and photothermal efficiency of anisotropic spiked gold nanostructures are requisite. Gold Nanostars (GNS), nanobipyramids (GNB) possess exceptional tip-enhanced plasmonic characteristics. GNB and GNS were synthesized and surface modified with MUC1 aptamer. GNB and GNS exhibited photothermal conversion efficiency of 14.5 and 14.1%, respectively. GNB and GNS are much less cytotoxic after aptamer conjugation. Compared with aptamer-GNS, aptamer-GNB exhibited higher selective cellular internalization toward MCF7 cell lines. Photoablation studies revealed that MCF7 cell lines were more severely damaged by aptamer-GNB than by aptamer-GNS.
DOI: 10.15468/dl.hkauvc
title: Occurrence Download

description: A dataset containing 47 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "DatasetKey" : [
 "is Global database of alien macrofungi"
 ]
 }
 },
 "TaxonKey is Tubercularia minor Link"
 ]
}

 The dataset includes 47 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002425-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.69q3ss
title: Occurrence Download

description: A dataset containing 88 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Scinax strigilatus (Spix, 1824)"
 ]
}

 The dataset includes 88 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002426-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9tyc6m
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "DatasetKey" : [
 "is Global database of alien macrofungi"
 ]
 }
 },
 "TaxonKey is Tubercularia ulmea J.C.Carter"
 ]
}

 The dataset includes 21 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002427-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b3ez47
title: Occurrence Download

description: A dataset containing 491 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Sweden",
 "Geometry POLYGON((11.40677 58.24501,11.57816 58.24501,11.57816 58.33038,11.40677 58.33038,11.40677 58.24501))",
 "HasCoordinate is true",
 "TaxonKey is Mnemiopsis leidyi A.Agassiz, 1865"
 ]
}

 The dataset includes 491 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002430-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.10891140
title: Dataset for "Dissociable Roles of the mPFC-to-VTA pathway in the control od Impulsive action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats"

description: This dataset corresponds to the study "Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats". In this study, we used Positron Emission Tomography with [18F]-Fluorodeoxyglucose to evaluate brain metabolic activity in Roman High- (RHA) and Low-avoidance (RLA) rats, which exhibit innate differences in impulsivity. Notably, we used a viral-based intersectional chemogenetic strategy to isolate the role of the mPFC-to-VTA pathway in controlling impulsive behaviors. We selectively activated the mPFC-to-VTA pathway in RHA rats and inhibited it in RLA rats, assessing the effects on impulsive action and RDM in the rat gambling task. Our results showed that RHA rats displayed higher impulsive action, less optimal decision-making, and lower cortical activity than RLA rats at baseline. Chemogenetic activation of the mPFC-to-VTA pathway reduced impulsive action in RHA rats, whereas chemogenetic inhibition had the opposite effect in RLA rats. However, these manipulations did not affect RDM. Our findings suggest a dissociable role of the mPFC-to-VTA pathway in impulsive action and RDM, highlighting its potential as a target for investigating impulsivity-related disorders.

Contributions for usage of this data in publications:

If you publish any work using these data, please cite this repository and the associated publication.
DOI: 10.5281/zenodo.10891141
title: Dataset for "Dissociable Roles of the mPFC-to-VTA pathway in the control od Impulsive action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats"

description: This dataset corresponds to the study "Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats". In this study, we used Positron Emission Tomography with [18F]-Fluorodeoxyglucose to evaluate brain metabolic activity in Roman High- (RHA) and Low-avoidance (RLA) rats, which exhibit innate differences in impulsivity. Notably, we used a viral-based intersectional chemogenetic strategy to isolate the role of the mPFC-to-VTA pathway in controlling impulsive behaviors. We selectively activated the mPFC-to-VTA pathway in RHA rats and inhibited it in RLA rats, assessing the effects on impulsive action and RDM in the rat gambling task. Our results showed that RHA rats displayed higher impulsive action, less optimal decision-making, and lower cortical activity than RLA rats at baseline. Chemogenetic activation of the mPFC-to-VTA pathway reduced impulsive action in RHA rats, whereas chemogenetic inhibition had the opposite effect in RLA rats. However, these manipulations did not affect RDM. Our findings suggest a dissociable role of the mPFC-to-VTA pathway in impulsive action and RDM, highlighting its potential as a target for investigating impulsivity-related disorders.

Contributions for usage of this data in publications:

If you publish any work using these data, please cite this repository and the associated publication.
DOI: 10.5281/zenodo.13889297
title: SPSS spreadsheet data

description: This is a dataset analysis regarding our previous research and the current research. it is the result of our observations over 3 years of monitoring and is provided briefly within our 1st publication: https://doi.org/10.5281/zenodo.10407923.
DOI: 10.5281/zenodo.13889298
title: SPSS spreadsheet data
DOI: 10.5281/zenodo.13902598
title: SPSS spreadsheet data

description: This is a dataset analysis regarding our previous research and the current research. it is the result of our observations over 3 years of monitoring and is provided briefly within our 1st publication: https://doi.org/10.5281/zenodo.10407923.