cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4869351
title: Androstenone, skatole and the olfactory perception of boar taint

description: Fat samples from roughly a thousand pig carcasses were collected and subjected to a thorough sensory evaluation and quantification using a panel of 10 trained assessors on a sensory score scale ranging from 0 = ‘untainted’ to 5 = ‘strongly tainted’. The following variables are available in the dtR.csv data set: rater: the ID of the panelist/assessor product: the product ID dev: deviation from normal smell according to the respective rater, ordinal score between 0 = ‘untainted’ and 5 = ‘strongly tainted’ (see above) andro: the product’s androstenone content (in ppm) skatol: the product’s skatole content (in ppm) The following variables are available in the (aggregated) dtM.csv data set: product: the product id mdev: mean deviation from normal smell (across panelists) of the respective product andro: the product’s androstenone content (in ppm) skatol: the product’s skatole content (in ppm) If using the data, please cite: Daniel Mörlein, Johanna Trautmann, Jan Gertheiss, Lisa Meier-Dinkel, Jochen Fischer, Hans-Jörg Eynck, Lourens Heres, Christian Looft, and Ernst Tholen (2016). Interaction of skatole and androstenone in the olfactory perception of boar taint. <em>Journal of Agricultural and Food Chemistry</em>, 64, 4556-4565 Available at: https://pubs.acs.org/doi/10.1021/acs.jafc.6b00355
description: The data were collected as part of STRAT-E-GER project supported by funds of the Federal Ministry of Food and Agriculture (BMEL) based on a decision of the Parliament of the Federal Republic of Germany via the Federal Office for Agriculture and Food (BLE) under the innovation support program.
description: {"references": ["M\u00f6rlein et al. (2016). Interaction of skatole and androstenone in the olfactory perception of boar taint. Journal of Agricultural and Food Chemistry, 64, 4556-4565"]}
DOI: 10.5281/zenodo.4683190
title: 235 Shades of Pink

description: Subjects are asked to distinguish color chips from a reference (with L=57, a=25, b=6 in Lab space) using triangle tests. The variables in ColData.csv are as follows: id: subject ID ldd: the level/direction identifier, corresponding Lab values are found in LabDef.csv correct: 1= yes, 0= no by: year of birth gender: 1= female, 2= male, 3= diverse occupation: 1= employee, 2= student (university), 3= self-employed, 4= trainee, 5= student (high school), 6= other experience: 1= experience in the color industry (e.g. painter, graphic designer) 2= no industry experience, 3= I do not know device: 1= iPhone, 2= iPad, 3= Macbook, 4= iMac, 5= Smartphone (other), 6= Notebook (other), 7= Tablet (other), 8= PC, 9= other <br> Our data analysis is found in ColAnalysis.html. If using the data, please cite: B.A. Altmann, J. Gertheiss, I. Tomasevic, C. Engelkes, T. Glaesener, J. Meyer, A. Schäfer, R. Wiesen, and D. Mörlein (2022): Human perception of color differences using computer vision system measurements of raw pork loin. <em>Meat Science</em>, in press. https://www.sciencedirect.com/science/article/abs/pii/S0309174022000341
description: These data were collected as part of the Research-Oriented Teaching and Learning (Forschungsorientiertes Lehren und Lernen) program funded by the German Federal Ministry of Education and Research (Funding Nr.: 01PL16061).
DOI: 10.5281/zenodo.4683189
title: 235 Shades of Pink

description: Subjects are asked to distinguish color chips from a reference (with L=57, a=25, b=6 in Lab space) using triangle tests. The variables in ColData.csv are as follows: id: subject ID ldd: the level/direction identifier, corresponding Lab values are found in LabDef.csv correct: 1= yes, 0= no by: year of birth gender: 1= female, 2= male, 3= diverse occupation: 1= employee, 2= student (university), 3= self-employed, 4= trainee, 5= student (high school), 6= other experience: 1= experience in the color industry (e.g. painter, graphic designer) 2= no industry experience, 3= I do not know device: 1= iPhone, 2= iPad, 3= Macbook, 4= iMac, 5= Smartphone (other), 6= Notebook (other), 7= Tablet (other), 8= PC, 9= other <br> Our data analysis is found in ColAnalysis.html. If using the data, please cite: B.A. Altmann, J. Gertheiss, I. Tomasevic, C. Engelkes, T. Glaesener, J. Meyer, A. Schäfer, R. Wiesen, and D. Mörlein (2022): Human perception of color differences using computer vision system measurements of raw pork loin. <em>Meat Science</em>, in press. https://www.sciencedirect.com/science/article/abs/pii/S0309174022000341
description: These data were collected as part of the Research-Oriented Teaching and Learning (Forschungsorientiertes Lehren und Lernen) program funded by the German Federal Ministry of Education and Research (Funding Nr.: 01PL16061).
DOI: 10.5281/zenodo.6276446
title: Data set for the article 'Temporal scaling in C. elegans larval development'

description: This directory contains all analyzed data and data analysis scripts to create all figures for the article<br> Filina et al., Temporal scaling in C. elegans larval development, PNAS 2022 119:e2123110119
DOI: 10.5281/zenodo.6276445
title: Data set for the article 'Temporal scaling in C. elegans larval development'

description: This directory contains all analyzed data and data analysis scripts to create all figures for the article<br> Filina et al., Temporal scaling in C. elegans larval development, PNAS 2022 119:e2123110119
DOI: 10.12755/fostat.doc.2022.2
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : เคอร์คิวมินต่อการทำงานปกติของข้อต่อ
DOI: 10.12755/fostat.doc.2022.3
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : ผลิตภัณฑ์คอลลาเจนไฮโดรไลเซทและการเปลี่ยนแปลงความยืดหยุ่นของผิวหนังกับการปรับปรุงหน้าที่การทำงานของผิวหนัง
DOI: 10.5281/zenodo.6277343
title: data set related to article An Exploratory Study of Emotional Dysregulation Dimensions in Youth With Attention Deficit Hyperactivity Disorder and/or Bipolar Spectrum Disorders

description: This record contains raw data related to article An Exploratory Study of Emotional Dysregulation Dimensions in Youth With Attention Deficit Hyperactivity Disorder and/or Bipolar Spectrum Disorders
DOI: 10.12755/fostat.doc.2022.4
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : ไรย์ไฟเบอร์ต่อการเปลี่ยนแปลงการทำงานของลำไส้ การลดระดับน้ำตาลในเลือดหลังอาหาร (reduction of post-prandial glycaemic responses) และการรักษาระดับความเข้มข้นของ แอลดีแอล-คอเลสเตอรอล (LDL-cholesterol) ในกระแสเลือดให้คงอยู่ในระดับปกติ
DOI: 10.5281/zenodo.6276368
title: data set related to article An Exploratory Study of Emotional Dysregulation Dimensions in Youth With Attention Deficit Hyperactivity Disorder and/or Bipolar Spectrum Disorders

description: This record contains raw data related to article An Exploratory Study of Emotional Dysregulation Dimensions in Youth With Attention Deficit Hyperactivity Disorder and/or Bipolar Spectrum Disorders
DOI: 10.12755/fostat.doc.2022.5
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : ข้าวกล้องงอกต่อการควบคุมความดันโลหิตให้ปกติ และประชากรเป้าหมายของการกล่าวอ้างคือผู้ใหญ่ที่มีภาวะ Metabolic syndrome
DOI: 10.12755/fostat.doc.2022.6
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : Resistant maltodextrin ในการลดการตอบสนองต่อระดับน้ำตาลในเลือดที่เพิ่มหลังจากรับประทานอาหาร การควบคุมความเข้มข้นของ LDL-cholesterol และความเข้มข้นของไตรกลีเซอไรด์ในเลือดให้ปกติ และการเปลี่ยนแปลงการทำงานของลำไส้
DOI: 10.12755/fostat.doc.2022.7
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : โคลีนต่อการเผาผลาญไขมันในร่างกาย บำรุงรักษาการทำงานของตับ ส่งเสริมการทำงานของโฮโมซิสเตอีนเมแทบอลิซึม ควบคุมการทำงานของระบบประสาท และส่งเสริมความรู้ความเข้าใจตามปกติ รวมถึงการพัฒนาสมองและระบบประสาท
DOI: 10.12755/fostat.doc.2022.8
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : เวย์โปรตีนต่อการเพิ่มระดับความอิ่มนำไปสู่การลดใช้พลังงาน ควบคุมระดับน้ำหนักตัวให้ปกติและการเจริญเติบโตของมวลกล้ามเนื้อ เพิ่มมวลร่างกายที่ปราศจากไขมันในช่วงจำกัดพลังงาน ลดมวลไขมันในร่างกายในช่วงที่จำกัดพลังงาน เพิ่มความแข็งแรงของกล้ามเนื้อและความสามารถในระหว่างการแข่งขันครั้งต่อไปหลังจากการออกกำลังกายอย่างหนักซ่อมแซมเนื้อเยื่อของกล้ามเนื้อและฟื้นตัวได้เร็วขึ้นจากความเหนื่อยล้าหลังออกกำลังกาย
DOI: 10.12755/fostat.doc.2022.9
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : เบต้า-กลูแคนจากโอ๊ต และการลดลงของคอเลสเตอรอลในเลือด และการลดความเสี่ยงของการเกิดโรคหลอดเลือดหัวใจ
DOI: 10.12755/fostat.doc.2022.10
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : ผลิตภัณฑ์นมเปรี้ยวที่มีแลคโตบาซิลลัส คาเซอิ สายพันธุ์ DN-1140 (Lactobacillus casei DN-114001) และเชื้อโยเกิร์ต (Lactobacillus delbrueckii subsp. bulgaricus และ Streptococcus thermophilus) และการลดปริมาณสารพิษจาก Clostridium difficile ในลำไส้ซึ่งจะลดอุบัติการณ์ของโรคอุจจาระร่วงเฉียบพลัน (Acute diarrhoea)
DOI: 10.12755/fostat.doc.2022.11
title: กรณีศึกษา EFSA ข้อคิดเห็นทางวิชาการและการพิสูจน์การกล่าวอ้างเชิงสุขภาพ (EFSA case study: Scientific opinion and health claim substantiation) : โกโก้ฟลาวานอลและการคงภาวะปกติของการขยายตัวของเยื่อบุผนังหลอดเลือด
DOI: 10.5281/zenodo.5997144
title: Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction

description: Dataset from Malvindi PG, Lorusso R, Jiritano F, Santarpino G, Pilato M, Cammardella AG, van Putte B, Bonaros N, Garatti A, Paparella D. Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction. Ann Thorac Surg. 2021 Apr;111(4):e271-e273. doi: 10.1016/j.athoracsur.2020.06.138. Epub 2020 Sep 24. PMID: 32979373. Abstract Structural valve degeneration, valve thrombosis, or acute infective endocarditis may affect the postprocedural outcome of transcatheter aortic valve implanted (TAVI) prostheses. Data of patients who required late surgical explant of TAVI prostheses were obtained from 8 European centers. There were 13 patients who underwent surgical treatment for TAVI prosthesis failure after original admission due to prosthetic infective endocarditis in 6 patients, structural valve degeneration in 4, and valve thrombosis in 3. Hospital mortality was 15%, and survival at the 2-year follow-up was 71%. Abstract word count: 80.
DOI: 10.5281/zenodo.5997143
title: Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction

description: Dataset from Malvindi PG, Lorusso R, Jiritano F, Santarpino G, Pilato M, Cammardella AG, van Putte B, Bonaros N, Garatti A, Paparella D. Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction. Ann Thorac Surg. 2021 Apr;111(4):e271-e273. doi: 10.1016/j.athoracsur.2020.06.138. Epub 2020 Sep 24. PMID: 32979373. Abstract Structural valve degeneration, valve thrombosis, or acute infective endocarditis may affect the postprocedural outcome of transcatheter aortic valve implanted (TAVI) prostheses. Data of patients who required late surgical explant of TAVI prostheses were obtained from 8 European centers. There were 13 patients who underwent surgical treatment for TAVI prosthesis failure after original admission due to prosthetic infective endocarditis in 6 patients, structural valve degeneration in 4, and valve thrombosis in 3. Hospital mortality was 15%, and survival at the 2-year follow-up was 71%. Abstract word count: 80.
DOI: 10.25934/pr00005847.1
title: Available IPD datapackage for study 'Randomised, Double-blind, Parallel-group, Placebo-controlled, Fixed Dose Study on the Efficacy of [Vortioxetine] Lu AA21004 on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder (MDD)'

description: Major Depressive Disorder (MDD) is a severe and common psychiatric disorder. Although MDD primarily involves mood disturbances, patients also usually present alterations in cognitive function (attention, memory, executive functioning and psychomotor speed). Even though antidepressants are suggested in the literature to potentially improve cognitive dysfunction in patients with MDD to some degree, there is a lack of adequate and well-controlled studies to investigate this effect. This study will evaluate the efficacy, safety and tolerability of a new antidepressant Vortioxetine versus placebo on cognitive dysfunction in adult patients with MDD.
DOI: 10.25934/pr00007385
title: Cognitive predictors of antidepressant treatment outcome in patients with major depressive disorder

description: Cognitive difficulties, such as problems with attention, concentration, decision-making and memory, are a core component of major depression. While symptom questionnaires can assess subjective experience of cognitive difficulties, objective task-based measures are required for more directly assessing cognition. Using such task-based measures, prior studies have in general found that patients with a more profound impairment in cognition have a worse response to treatment with antidepressants. However, these studies have primarily not been gold-standard studies where the patient does not know if they are taking a drug or a placebo. There is, as a consequence, very little information about what either predicts antidepressant response differently from placebo, or predicts placebo response differently from antidepressants. As such, understanding the relationship between pretreatment cognition and placebo response is of paramount importance as doing so may elucidate what sort of cognitive profile is associated with a larger (or smaller) net benefit of antidepressants over placebo, as well as whether the ability of pre-treatment cognition to predict improvement in depression symptoms is something that is equally relevant to placebo as active antidepressants. The consequence of such analyses may allow identification of subgroups of depressed patients that may be particularly sensitive to antidepressants relative to placebo, and others which derive little or no benefit from antidepressants over placebo and thus particularly in need for new types of interventions being developed across the field. We will address these questions using a variety of statistical analyses of cognitive and clinical data from several studies of vortioxetine in patients with depression, which included a placebo arm and in some cases also a different antidepressant. These datasets were chosen for their size relative to previously published individual lab datasets, as well as the ability to replicate findings across studies. Our statistical methods will be ones common to clinical trial research, as well as those more closely related to simple forms of machine learning. Given the broad relevance of the proposed analyses, meaningful impact is expected for the general population of depressed patients (22M in the US alone), as well as patients with anxiety or trauma-related disorders in which antidepressant treatment is also a mainstay (10M's in the US). Indeed, at present it is estimated that one in eight in the US is on an antidepressant at any given time, thus illustrating both the breadth and need for a precision approach such as that described herein.
DOI: 10.48370/ofd/lnri3y
title: Plicatura crispa (Pers.) Rea, 534

description: Fungarium Makromycetes
DOI: 10.5517/ccdc.csd.cc294bph
title: CCDC 2119336: Experimental Crystal Structure Determination

description: Related Article: Xiancui Zhu, Yawen Qi, Yuanqing Yang, Dianjun Guo, Zeming Huang, Lijun Zhang, Yun Wei, Shuangliu Zhou, Shaowu Wang|2022|Inorg.Chem.|61|3202|doi:10.1021/acs.inorgchem.1c03673
DOI: 10.5517/ccdc.csd.cc294bqj
title: CCDC 2119337: Experimental Crystal Structure Determination

description: Related Article: Xiancui Zhu, Yawen Qi, Yuanqing Yang, Dianjun Guo, Zeming Huang, Lijun Zhang, Yun Wei, Shuangliu Zhou, Shaowu Wang|2022|Inorg.Chem.|61|3202|doi:10.1021/acs.inorgchem.1c03673
DOI: 10.5517/ccdc.csd.cc294brk
title: CCDC 2119338: Experimental Crystal Structure Determination

description: Related Article: Xiancui Zhu, Yawen Qi, Yuanqing Yang, Dianjun Guo, Zeming Huang, Lijun Zhang, Yun Wei, Shuangliu Zhou, Shaowu Wang|2022|Inorg.Chem.|61|3202|doi:10.1021/acs.inorgchem.1c03673
DOI: 10.5517/ccdc.csd.cc294bsl
title: CCDC 2119339: Experimental Crystal Structure Determination

description: Related Article: Xiancui Zhu, Yawen Qi, Yuanqing Yang, Dianjun Guo, Zeming Huang, Lijun Zhang, Yun Wei, Shuangliu Zhou, Shaowu Wang|2022|Inorg.Chem.|61|3202|doi:10.1021/acs.inorgchem.1c03673
DOI: 10.5517/ccdc.csd.cc29643s
title: CCDC 2121054: Experimental Crystal Structure Determination

description: Related Article: Satish K. Patel, Ram N. Patel, Abhay K. Patel, Neetu Patel, D. Choquesillo-Lazarte|2022|J.Mol.Struct.|1257|132545|doi:10.1016/j.molstruc.2022.132545
DOI: 10.5517/ccdc.csd.cc29644t
title: CCDC 2121055: Experimental Crystal Structure Determination

description: Related Article: Satish K. Patel, Ram N. Patel, Abhay K. Patel, Neetu Patel, D. Choquesillo-Lazarte|2022|J.Mol.Struct.|1257|132545|doi:10.1016/j.molstruc.2022.132545
DOI: 10.5517/ccdc.csd.cc29645v
title: CCDC 2121056: Experimental Crystal Structure Determination

description: Related Article: Satish K. Patel, Ram N. Patel, Abhay K. Patel, Neetu Patel, D. Choquesillo-Lazarte|2022|J.Mol.Struct.|1257|132545|doi:10.1016/j.molstruc.2022.132545
DOI: 10.48370/ofd/dzi401
title: Plicatura crispa (Pers.) Rea, 651

description: Fungarium Makromycetes
DOI: 10.5517/ccdc.csd.cc29f9vx
title: CCDC 2127959: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Yibin Xue, Rui Zhang, Benjamin L. Ratchford, Guangbin Dong|2022|J.Am.Chem.Soc.|144|3242|doi:10.1021/jacs.1c13342
DOI: 10.5517/ccdc.csd.cc29f9wy
title: CCDC 2127960: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Yibin Xue, Rui Zhang, Benjamin L. Ratchford, Guangbin Dong|2022|J.Am.Chem.Soc.|144|3242|doi:10.1021/jacs.1c13342
DOI: 10.5517/ccdc.csd.cc29fmq3
title: CCDC 2128265: Experimental Crystal Structure Determination

description: Related Article: Thomas Höllerhage, Thomas P. Spaniol, Ambre Carpentier, Laurent Maron, Jun Okuda|2022|Inorg.Chem.|61|3309|doi:10.1021/acs.inorgchem.1c03894
DOI: 10.5517/ccdc.csd.cc29fmr4
title: CCDC 2128266: Experimental Crystal Structure Determination

description: Related Article: Thomas Höllerhage, Thomas P. Spaniol, Ambre Carpentier, Laurent Maron, Jun Okuda|2022|Inorg.Chem.|61|3309|doi:10.1021/acs.inorgchem.1c03894
DOI: 10.5517/ccdc.csd.cc29fms5
title: CCDC 2128267: Experimental Crystal Structure Determination

description: Related Article: Thomas Höllerhage, Thomas P. Spaniol, Ambre Carpentier, Laurent Maron, Jun Okuda|2022|Inorg.Chem.|61|3309|doi:10.1021/acs.inorgchem.1c03894
DOI: 10.5517/ccdc.csd.cc29fmt6
title: CCDC 2128268: Experimental Crystal Structure Determination

description: Related Article: Thomas Höllerhage, Thomas P. Spaniol, Ambre Carpentier, Laurent Maron, Jun Okuda|2022|Inorg.Chem.|61|3309|doi:10.1021/acs.inorgchem.1c03894
DOI: 10.6084/m9.figshare.19235613
title: Supplementary Material for: Initial Proportion and Dynamic of B.1.1.7 SARS-CoV-2 in a Large City in the West of Germany

description: <b><i>Rationale:</i></b> Several mutational variants of SARS-CoV-2 have been identified in the past months with increasing prevalence worldwide. Some variants, such as B.1.1.7, are of high relevance due to increased transmissibility, facilitating virus spread and calling for stricter containment measures. <b><i>Objectives:</i></b> The aim of this study was to examine proportion and dynamic of B.1.1.7 in SARS-CoV-2-positive samples in a large city in the west of Germany. <b><i>Methods:</i></b> Consecutive SARS-CoV-2-positive samples from a local outpatient clinic, obtained over a period of 4 weeks (mid-January to mid-February 2021), were examined for the presence of the variant B.1.1.7. The size of B.1.1.7 infection clusters was compared with non-B.1.1.7 clusters. The transmissibility of SARS-CoV-2 variant B.1.1.7 was described based on corresponding cases of an infection cluster in a local child daycare centre. <b><i>Results:</i></b> Among 226 SARS-CoV-2-positive cases, B.1.1.7 was detected in 74 subjects (33%). The 7-day moving mean of the B.1.1.7 proportion started at 20% and reached 50% only 3 weeks later. B.1.1.7 clusters comprised 10.7 ± 12.1 persons per cluster, while non-B.1.1.7 clusters were considerably smaller (5.1 ± 5.8). One specific B.1.1.7 infection cluster in a 40-children daycare centre started with one teacher leading to 11 infected children and 8 infections among teachers. The infection spread to 6 families and one other daycare centre, with a total 43 SARS-CoV-2-positive subjects. <b><i>Conclusions:</i></b> We found a rapid increase in the SARS-CoV-2 variant B.1.1.7 with larger infection clusters than non-B.1.1.7. These results suggested a rapid increase in the B.1.1.7 proportion and a renewed increase in the total number of SARS-CoV-2 infections for the time following the analysed period. Considering the rapid emergence and spread of viral variants, close monitoring of mutation events is essential. Therefore, routine whole-genome sequencing appears to be useful in addition to searching for known mutations.
DOI: 10.6084/m9.figshare.19235613.v1
title: Supplementary Material for: Initial Proportion and Dynamic of B.1.1.7 SARS-CoV-2 in a Large City in the West of Germany

description: <b><i>Rationale:</i></b> Several mutational variants of SARS-CoV-2 have been identified in the past months with increasing prevalence worldwide. Some variants, such as B.1.1.7, are of high relevance due to increased transmissibility, facilitating virus spread and calling for stricter containment measures. <b><i>Objectives:</i></b> The aim of this study was to examine proportion and dynamic of B.1.1.7 in SARS-CoV-2-positive samples in a large city in the west of Germany. <b><i>Methods:</i></b> Consecutive SARS-CoV-2-positive samples from a local outpatient clinic, obtained over a period of 4 weeks (mid-January to mid-February 2021), were examined for the presence of the variant B.1.1.7. The size of B.1.1.7 infection clusters was compared with non-B.1.1.7 clusters. The transmissibility of SARS-CoV-2 variant B.1.1.7 was described based on corresponding cases of an infection cluster in a local child daycare centre. <b><i>Results:</i></b> Among 226 SARS-CoV-2-positive cases, B.1.1.7 was detected in 74 subjects (33%). The 7-day moving mean of the B.1.1.7 proportion started at 20% and reached 50% only 3 weeks later. B.1.1.7 clusters comprised 10.7 ± 12.1 persons per cluster, while non-B.1.1.7 clusters were considerably smaller (5.1 ± 5.8). One specific B.1.1.7 infection cluster in a 40-children daycare centre started with one teacher leading to 11 infected children and 8 infections among teachers. The infection spread to 6 families and one other daycare centre, with a total 43 SARS-CoV-2-positive subjects. <b><i>Conclusions:</i></b> We found a rapid increase in the SARS-CoV-2 variant B.1.1.7 with larger infection clusters than non-B.1.1.7. These results suggested a rapid increase in the B.1.1.7 proportion and a renewed increase in the total number of SARS-CoV-2 infections for the time following the analysed period. Considering the rapid emergence and spread of viral variants, close monitoring of mutation events is essential. Therefore, routine whole-genome sequencing appears to be useful in addition to searching for known mutations.