cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24787356.v1
title: Supplementary Material for: Twelve-months outcomes after metabolic and bariatric surgery among youths participating in a structured preparation and follow-up program – Results of the Youth with Extreme obesity Study (YES)

description: Introduction: While invasive and associated with risks, metabolic and bariatric surgery (MBS) can promote sustained weight loss and substantial health benefits in youths with extreme obesity.The path toward informed decision making for or against MBS is poorly characterized and postoperative follow-up to assess risks and benefits is inconsistent. In youths with extreme obesity we aimed to evaluate decision making toward MBS, as well as MBS outcomes and adherence with follow-up and recommendations in the setting of a structured pre- and post- MBS.
Methods: Participants were recruited in the setting of the multicenter “Youth with Extreme Obesity Study” (YES). YES is a cohort study in adolescents and young adults aged 14–24 years with obesity (BMI≥30.0 kg/m2) who were recruited at four medical centers and one job center in Germany between 2012 and 2018. Participants at two medical centers with BMI≥35kg/m2, aged 14-24 years, and interested in pursuing MBS were included in the subproject 3 “Safety and effectiveness of weight loss surgery in adolescents with severe obesity within a structured pre- and post-surgery treatment program – an observational study” that comprised a 2-months pre- and 12-months post-MBS program. 
Results: Twenty-eight of 169 youths (17%) with BMI≥35kg/m2 were interested in MBS. Twenty-six fulfilled published eligibility criteria for MBS and participated in the structured pre- MBS preparation program. Of these, 9 participants (2 female) decided against, and 17 (n=11 females) decided for MBS (sleeve gastrectomy). The 12-months follow-up rate was high (16/17 [94%]) and all participants achieved significant weight reduction (ΔBMI:-16.1±5.6 kg/m2). Eleven of 16 participants (69%) reported taking the prescribed dietary supplements in the first year after MBS, but only five of them (31%) did so daily. In contrast to the high 12-month retention rate, follow-up after completion of the structured program was low at 24-months (9/16 [56%]) and at 36-months (5/15 [36%]) respectively. 
Conclusion: Participants demonstrated active decision making for or against MBS and high adherence with the structured pre- and 12 months post- MBS program, but participation was low thereafter. These findings endorse the need for longer-term structured post-MBS programs to capture long-term outcomes and provide adequate care in this vulnerable group at the transition to adulthood.
DOI: 10.14284/652
title: LifeWatch observatory data: nutrient, pigment, suspended matter and secchi measurements in the Belgian Part of the North Sea

description: In the framework of the Lifewatch marine observatory a number of fixed stations on the Belgian Part of the North Sea (BPNS) are visited on a monthly or seasonal basis using the RV Simon Stevin. A grid of nine stations covers the coastal zone and are sampled monthly. Eight additional stations, located further at sea, are sampled on a seasonal basis.

This dataset contains measurements of nutrients, pigments, suspended matter and secchi measurements in the Belgian Part of the North Sea (BPNS) since 2001.
DOI: 10.6084/m9.figshare.24893181
title: Supplementary Material for: Hypoglycemia in Children Referred to a Tertiary Care Pediatric Endocrine Clinic: Age-Dependent Etiological Variations

description: Introduction: Diagnosing hypoglycemia in infants and children presents significant challenges. Our objective was to elucidate the diagnoses and clinical features of children with hypoglycemia referred to a pediatric endocrine tertiary clinic.

Methods: Retrospective study of 154 children (0-18 years old) presenting with hypoglycemia, during 1992-2018. 

Results: The cohort was divided by clinical diagnosis into six groups: ketotic hypoglycemia (n=45, 29.2%), congenital hyperinsulinemic hypoglycemia (n=35, 22.7%), transient hyperinsulinemic hypoglycemia (n=28, 18.2%), metabolic disorder (n=14, 9.1%), systemic disease/syndrome (n=15, 9.7%), and hormone deficiencies (n=8, 5.2%). Two patients had insulinoma and in 7 (4.5%) no diagnosis was elucidated. At diagnosis, 58 (37.7%) were &lt;1 month old, 23 (14.9%) aged 1-12 months, 58 (37.7%) aged 1-6 years, and 15 (9.7%) aged 6-18 years. Hypoglycemia etiology varied among neonates, infants, and children. In eight patients hypoglycemia was asymptomatic. Of 47 patients who completed a diagnostic fast, 31 became hypoglycemic, yet a significant added value for diagnosis was only found in 14 (29.8%) patients. 

Conclusions: Hypoglycemia etiology in children is heterogeneous and varies by age. Any hypoglycemia measured in a child should be seriously evaluated as 7% are asymptomatic. Work-up should be tailored based on age, and clinical, biochemical, and imaging findings. Despite extensive work-up, in a significant number of patients the mechanism underlying pediatric hypoglycemia remains an enigma. This emphasizes the unmet needs and challenges in studying pediatric hypoglycemia.
DOI: 10.6084/m9.figshare.24893181.v1
title: Supplementary Material for: Hypoglycemia in Children Referred to a Tertiary Care Pediatric Endocrine Clinic: Age-Dependent Etiological Variations

description: Introduction: Diagnosing hypoglycemia in infants and children presents significant challenges. Our objective was to elucidate the diagnoses and clinical features of children with hypoglycemia referred to a pediatric endocrine tertiary clinic.

Methods: Retrospective study of 154 children (0-18 years old) presenting with hypoglycemia, during 1992-2018. 

Results: The cohort was divided by clinical diagnosis into six groups: ketotic hypoglycemia (n=45, 29.2%), congenital hyperinsulinemic hypoglycemia (n=35, 22.7%), transient hyperinsulinemic hypoglycemia (n=28, 18.2%), metabolic disorder (n=14, 9.1%), systemic disease/syndrome (n=15, 9.7%), and hormone deficiencies (n=8, 5.2%). Two patients had insulinoma and in 7 (4.5%) no diagnosis was elucidated. At diagnosis, 58 (37.7%) were &lt;1 month old, 23 (14.9%) aged 1-12 months, 58 (37.7%) aged 1-6 years, and 15 (9.7%) aged 6-18 years. Hypoglycemia etiology varied among neonates, infants, and children. In eight patients hypoglycemia was asymptomatic. Of 47 patients who completed a diagnostic fast, 31 became hypoglycemic, yet a significant added value for diagnosis was only found in 14 (29.8%) patients. 

Conclusions: Hypoglycemia etiology in children is heterogeneous and varies by age. Any hypoglycemia measured in a child should be seriously evaluated as 7% are asymptomatic. Work-up should be tailored based on age, and clinical, biochemical, and imaging findings. Despite extensive work-up, in a significant number of patients the mechanism underlying pediatric hypoglycemia remains an enigma. This emphasizes the unmet needs and challenges in studying pediatric hypoglycemia.
DOI: 10.6084/m9.figshare.25003136
title: Geocoding-Feature_Selection

description: The growing popularity of location-based services has resulted in the enhancement of resources for producing geographical data and the development of the amount of data kept in geographic databases. The big data stored in databases is valuable for advanced geospatial analysis in several fields, including emergency responses, crime and traffic management, disease surveillance, and more. Geocoding, a crucial preprocessing step in geospatial data analysis, involves retrieving textual descriptions of locations into geographic identifiers. Nevertheless, geocoding outcomes delivered by worldwide service providers neglect various constraints related to textual data, including misspellings, abbreviations, and non-standard names. To overcome this issue, we propose a new approach for enhancing the quality of online geocoding services through the utilization of feature selection techniques. The proposed method is based on text similarity algorithms that are utilized to match the retrieved addresses. Compared to conventional geocoding outcomes, there is potential for an improvement of approximately 10% to 25% in the address-matching procedures employed in online geocoding services. The improvement was accomplished through the utilization of two feature selection methods, specifically mutual information feature selection and minimum redundancy maximum relevance, out of a total of fourteen approaches. Furthermore, the findings indicate that it is appropriate to prioritize character-based text similarity algorithms when comparing addresses retrieved from online geocoding services.
DOI: 10.6084/m9.figshare.25003136.v1
title: Geocoding-Feature_Selection

description: The growing popularity of location-based services has resulted in the enhancement of resources for producing geographical data and the development of the amount of data kept in geographic databases. The big data stored in databases is valuable for advanced geospatial analysis in several fields, including emergency responses, crime and traffic management, disease surveillance, and more. Geocoding, a crucial preprocessing step in geospatial data analysis, involves retrieving textual descriptions of locations into geographic identifiers. Nevertheless, geocoding outcomes delivered by worldwide service providers neglect various constraints related to textual data, including misspellings, abbreviations, and non-standard names. To overcome this issue, we propose a new approach for enhancing the quality of online geocoding services through the utilization of feature selection techniques. The proposed method is based on text similarity algorithms that are utilized to match the retrieved addresses. Compared to conventional geocoding outcomes, there is potential for an improvement of approximately 10% to 25% in the address-matching procedures employed in online geocoding services. The improvement was accomplished through the utilization of two feature selection methods, specifically mutual information feature selection and minimum redundancy maximum relevance, out of a total of fourteen approaches. Furthermore, the findings indicate that it is appropriate to prioritize character-based text similarity algorithms when comparing addresses retrieved from online geocoding services.
DOI: 10.5281/zenodo.10518334
title: 2024 GMAP Winter School - Venus basemap data sources (Magellan + VIRTIS data)

description: The provided data set displays the transition area between Themis Regio and Helen Planitia contains interesting geologic structures and shows surface emissivity anomalies that could be interpreated as variarions in Venus surface composition. This data set can be used to practice geologic mapping and surface emissivity in the open-source QGIS program.
DOI: 10.5281/zenodo.10518335
title: 2024 GMAP Winter School - Venus basemap data sources (Magellan + VIRTIS data)

description: The provided data set displays the transition area between Themis Regio and Helen Planitia contains interesting geologic structures and shows surface emissivity anomalies that could be interpreated as variarions in Venus surface composition. This data set can be used to practice geologic mapping and surface emissivity in the open-source QGIS program.
DOI: 10.6084/m9.figshare.24967776
title: Supplementary Material for: Network Analysis of Borderline Personality Features in Adolescence Using a Screening Tool in A Chinese Community Sample

description: Introduction: This study investigated the structure of the borderline personality features (BPF) network and the most central BPF in adolescence. Methods: Cross-sectional self-report data from 4,866 Chinese adolescents (M = 13.96, SD = 1.64; 61.3% girls) were included in the network analysis models. BPF were assessed with the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD). Results: Identity disturbance and affective instability emerged as the most central BPF in the current adolescent sample. In addition, chronic emptiness was also found with high centrality. The general networks of BPF were very similar between adolescent boys and girls, although some differences were detected. Discussion: This study further supports the necessity of BPD assessment and diagnosis in adolescence and identifies the distinctive importance of identity and affective dysregulation in the early development of BPD. The findings provide empirical insights into the interconnections of BPF, which resonate with therapeutic mechanisms of evidence-based treatments for BPD. However, the research was limited in its use of a screening measurement rather than a diagnostic tool. Future studies can further explore BPD psychopathology in adolescence with longitudinal data and clinical interviews.
DOI: 10.6084/m9.figshare.24972825
title: Supplementary Material for: Safety and efficacy of asciminib in chronic myeloid leukemia patient with chronic kidney diseases: a case report

description: Chronic myeloid leukemia is characterized by the presence of the BCR::ABL1 fusion gene, and tyrosine kinase inhibitors have revolutionized its treatment. Asciminib, a targeted ABL inhibitor, offers a promising alternative for patients who do not respond to or tolerate two or more conventional tyrosine kinase inhibitors. However, limited data exist regarding its safety and efficacy in individuals with chronic kidney disease. We present a case report of a 62-year-old chronic myeloid leukemia patient with stage 3 chronic kidney disease who experienced TKI intolerance, primarily due to fluid retention. Transitioning to asciminib therapy not only resulted in a deep molecular response but also did not exacerbate renal function, and resolve the fluid retention issue.
DOI: 10.6084/m9.figshare.24972825.v1
title: Supplementary Material for: Safety and efficacy of asciminib in chronic myeloid leukemia patient with chronic kidney diseases: a case report

description: Chronic myeloid leukemia is characterized by the presence of the BCR::ABL1 fusion gene, and tyrosine kinase inhibitors have revolutionized its treatment. Asciminib, a targeted ABL inhibitor, offers a promising alternative for patients who do not respond to or tolerate two or more conventional tyrosine kinase inhibitors. However, limited data exist regarding its safety and efficacy in individuals with chronic kidney disease. We present a case report of a 62-year-old chronic myeloid leukemia patient with stage 3 chronic kidney disease who experienced TKI intolerance, primarily due to fluid retention. Transitioning to asciminib therapy not only resulted in a deep molecular response but also did not exacerbate renal function, and resolve the fluid retention issue.
DOI: 10.6084/m9.figshare.25003208
title: Supplementary Material for: Chinese Multidisciplinary Expert Consensus on Immune Checkpoint Inhibitor (ICI)-Based Combination Therapy for Hepatocellular Carcinoma (2023 Edition)

description: Immune checkpoint inhibitor (ICI)-based combination therapy modalities for hepatocellular carcinoma (HCC) have achieved significant efficacy in clinical research and practice and have become the mainstay for the treatment of unresectable HCC. To better help clinicians use combination immunotherapy drugs and regimens rationally, effectively, and safely, the editorial board facilitated a discussion with multidisciplinary experts in the field, adopted the "Delphi" consensus formation method, and finally revised and completed the "Chinese Multidisciplinary Expert Consensus on the Immune Checkpoint Inhibitors (ICIs)-Based Combination Therapy for Hepatocellular Carcinoma (2023 Edition)" on the basis of the 2021 edition. This consensus primarily focuses on the principles and methods of clinical practice of combination therapy based on ICIs, aiming to summarize the recommendations for clinical application based on the latest research and expert experience and provide application guidance for clinicians.
DOI: 10.6084/m9.figshare.25003322.v1
title: Supplementary Material for: Identification and functional study of enhancers of EYA1, the causative gene of branchio-oto-renal syndrome

description: Introduction: Branchio-oto-renal syndrome (BOR syndrome) is a rare genetic disorder with an incidence of 1 in 40,000, affecting the development of multiple organs, including the branchio, ear and kidney. It is responsible for 2% of childhood deafness. Currently, variants in the coding regions of the main causative genes, such as EYA1, SIX1, and SIX5, explain only half of the disease’s etiology. Therefore, there is a need to explore the non-coding regions, which constitute the majority of the genome, especially the regulatory regions, as potential new causative factors. Method: In this study, we focused on the EYA1 gene, which accounts for over 40% of BOR syndrome cases, and conducted a screening of candidate enhancers within a 250 kb region upstream and downstream of the gene using comparative genomics. We characterized the enhancer activities of these candidates in zebrafish using the Tol2 transposon system. Results: Our findings revealed that out of the 11 conserved non-coding elements (CNEs) examined, four exhibited enhancer activity. Notably, CNE16.39 and CNE16.45 displayed tissue-specific enhancer activity in the ear. CNE16.39required the full-length 206 bp sequence for inner-ear-specific expression, while the core functional region of CNE16.45 was identified as 136 bp. Confocal microscopy results demonstrated that both CNE16.39 and CNE16.45 drove the expression of GFP in the sensory region of the crista of the inner ear in zebrafish, consistent with the expression pattern of eya1. Conclusion: This study contributes to the understanding of the regulatory network governing EYA1 expression and offers new insights to further clarify the pathogenic role of EYA1 in BOR syndrome.
DOI: 10.6084/m9.figshare.25003331.v1
title: Supplementary Material for: Chinese Multidisciplinary Expert Consensus on Immune Checkpoint Inhibitor (ICI)-Based Combination Therapy for Hepatocellular Carcinoma (2023 Edition)

description: Immune checkpoint inhibitor (ICI)-based combination therapy modalities for hepatocellular carcinoma (HCC) have achieved significant efficacy in clinical research and practice and have become the mainstay for the treatment of unresectable HCC. To better help clinicians use combination immunotherapy drugs and regimens rationally, effectively, and safely, the editorial board facilitated a discussion with multidisciplinary experts in the field, adopted the "Delphi" consensus formation method, and finally revised and completed the "Chinese Multidisciplinary Expert Consensus on the Immune Checkpoint Inhibitors (ICIs)-Based Combination Therapy for Hepatocellular Carcinoma (2023 Edition)" on the basis of the 2021 edition. This consensus primarily focuses on the principles and methods of clinical practice of combination therapy based on ICIs, aiming to summarize the recommendations for clinical application based on the latest research and expert experience and provide application guidance for clinicians.
DOI: 10.6084/m9.figshare.25003334
title: Supplementary Material for: Mental health of school-aged children treated with propranolol or atenolol for infantile hemangioma and their parents

description: Background: Infants with infantile hemangioma (IH) have been effectively treated with propranolol or atenolol. Concerns were raised about the mental health of these children at school-age, due to central nervous system effects of propranolol and visible nature of IH. 

Objective: This study aimed to compare the mental health at school-age of children treated with propranolol to children treated with atenolol for IHs, and their parents. 

Methods: This two-center cross-sectional study included children aged ≥6 years and treated with either propranolol or atenolol for IH during infancy. Children’s outcomes were performance-based affect recognition (NEPSY-II-NL), and parent-reported emotional and behavioral functioning (CBCL), and health-related quality of life (KIDSCREEN-27). Parents’ outcome was parenting stress (OBVL). 

Results: Data of 105 children (36 propranolol, 69 atenolol; 6.0 to 11.8 years) were analyzed. Mental health outcomes did not differ between both beta-blocker groups. Although overall functioning was in line with norms, children presented specific problems concerning affect recognition, and parent-reported attention and social quality of life. Parents showed increased physical symptoms, depressive symptoms, and parent-child relationship problems. 

Conclusion: No difference in mental health at school-age was found between children treated with propranolol or atenolol for IH. Although few overall mental health problems were found, specific problems require follow-up. Follow-up of children should be directed towards affect recognition, attention, and social functioning in daily life. Problems reported by parents could be ameliorated by mental health support during and after their infant’s beta-blocker treatment.
DOI: 10.5281/zenodo.10518707
title: Will women's representation reduce bribery? Trends in corruption and public service delivery across European regions

description: Dataset and replication files to 'Will women's representation reduce bribery? Trends in corruption and public service delivery across European regions', by Monika Bauhr, Nicholas Charron & Len Wängnerud, at Political Behavior.
description: Abstract:  While a growing body of work suggests that women's representation reduce overall corruption levels, we know less about if changes in representation patterns also have implications for citizens first hand experiences with public service delivery. This study posits that women elected representatives reduce street level bribery, in particular when the share of women increases in contexts where relatively few women are elected or when the absolute increase in women's representation is relatively large. Using newly collected data on the share of women in 128 regional level parliaments in 10 European countries and four rounds of the European Quality of Government Index (EQI) survey (2010-2021), our two way fixed effects models show that on average, the proportion of women in regional parliaments is strongly associated with citizens' self-reported experiences of bribery across all countries and years. Furthermore, our difference-in-difference design shows that the level of bribery in public service provision dropped more sharply in regions that experienced a greater absolute or greater marginal increase in women’s representation. Our results may be understood in light of women candidates priority on well functioning and low corrupt public service provision and important signals of inclusiveness and non-discrimination that an increase in women's representation conveys to civil servants.