cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25164146.v1
title: <b>Study on the Osmotic Response and Function of </b><b><i>Myo</i></b><b>-inositol Oxygenase in euryhaline fish Nile tilapia (</b><b><i>Oreochromis niloticus</i></b><b>)</b>

description: To understand the role of <i>myo</i>-inositol oxygenase (<i>miox</i>) in the osmotic regulation of Nile tilapia, its expression was analyzed in various tissues. The results showed that the expression of <i>miox</i> gene was highest in the kidney, followed by the liver, and was significantly upregulated in the kidney and liver under 1 h hyperosmotic stress. The relative luminescence efficiency of the <i>miox</i> gene transcription starting site (-4617 bp to +312 bp) under hyperosmotic stress was measured. Two fragments (-1640/-1619 and -620/-599) could induce the luminescence activity. Moreover, the -1640/-1619 and -620/-599 responded to hyperosmotic stress and high glucose stimulation by base mutation, suggesting that osmotic and carbohydrate response elements may exist in this region. Finally, the salinity tolerance of Nile tilapia was significantly reduced after the knocking down of <i>miox </i>gene. The accumulation of<i> myo</i>-inositol was affected and the expression of enzymes in glucose metabolism was significantly reduced after the <i>miox</i> gene was knocked down. Furthermore, hyperosmotic stress can cause oxidative stress, and MIOX may help maintain the cell redox balance under hyperosmotic stress. In summary, MIOX is essential in osmotic regulation to enhance the salinity tolerance of Nile tilapia by affecting <i>myo</i>-inositol accumulation, glucose metabolism and antioxidant performance.
DOI: 10.5517/ccdc.csd.cc2b0klj
title: CCDC 2145497: Experimental Crystal Structure Determination

description: Related Article: Guilin Ruan, Natalia Fridman, Galia Maayan|2022|Chem.-Eur.J.|28|e202202407|doi:10.1002/chem.202202407
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.12123717
title: A nonparametric statistical method for two crossing survival curves

description: In comparative research on time-to-event data for two groups, when two survival curves cross each other, it may be difficult to use the log-rank test and hazard ratio (HR) to properly assess the treatment benefit. Our aim was to identify a method for evaluating the treatment benefits for two groups in the above situation. We quantified treatment benefits based on an intuitive measure called the area between two survival curves (ABS), which is a robust measure of treatment benefits in clinical trials regardless of whether the proportional hazards assumption is violated or two survival curves cross each other. Additionally, we propose a permutation test based on the ABS, and we evaluate the effectiveness and reliability of this test with simulated data. The ABS permutation test is a robust statistical inference method with an acceptable type I error rate and superior power to detect differences in treatment effects, especially when the proportional hazards assumption is violated. The ABS can be used to intuitively quantify treatment differences over time and provide reliable conclusions in complicated situations, such as crossing survival curves.
DOI: 10.6084/m9.figshare.10026566
title: <i>IRX1</i> hypermethylation promotes heart failure by inhibiting CXCL14 expression

description: To identify the mechanism and functions of <i>IRX1</i> in heart failure (HF) and provide evidence for new therapies. Bioinformatic analysis was performed to select target genes in HF cells compared to normal groups. Experimental rats were treated in a controllable manner to explore how <i>IRX1</i> methylation accounted for this disease <i>in vivo</i>. Cardiac ultrasonic and morphologic examinations were conducted to test the mouse heart and evaluate the degree of cardiac impairment at in the level of organization. GSEA analysis revealed the relative enrichment of functions. Immunofluorescent assays, western blotting and qRT-PCR were used to determine the DNA methylation and expression levels. <i>IRX1</i> was hypermethylated in heart failure and identified as a target gene by bioinformatic analysis. Transverse aortic constriction (TAC) induced heart failure in rats, while 5-aza-2ʹ-deoxycytidine (5-Aza) alleviated heart failure in rats according to medical cardiac indexes. Western blotting and qRT-PCR revealed that a conspicuous difference in the expression of <i>IRX1</i> and <i>CXCL14</i> between HF and normal cardiac cells. As a result of gene methylation, left ventricular hypertrophy and cardiac fibrosis is usually accompanied by heart failure. Moreover, is the results implied that the demethylation of <i>IRX1</i> improves heart failure <i>in vivo</i> and <i>in vitro. IRX1</i> methylation induced damaged cardiac function and even heart failure, which has important implications for HF treatment and diagnosis.
DOI: 10.6084/m9.figshare.10026566.v1
title: <i>IRX1</i> hypermethylation promotes heart failure by inhibiting CXCL14 expression

description: To identify the mechanism and functions of <i>IRX1</i> in heart failure (HF) and provide evidence for new therapies. Bioinformatic analysis was performed to select target genes in HF cells compared to normal groups. Experimental rats were treated in a controllable manner to explore how <i>IRX1</i> methylation accounted for this disease <i>in vivo</i>. Cardiac ultrasonic and morphologic examinations were conducted to test the mouse heart and evaluate the degree of cardiac impairment at in the level of organization. GSEA analysis revealed the relative enrichment of functions. Immunofluorescent assays, western blotting and qRT-PCR were used to determine the DNA methylation and expression levels. <i>IRX1</i> was hypermethylated in heart failure and identified as a target gene by bioinformatic analysis. Transverse aortic constriction (TAC) induced heart failure in rats, while 5-aza-2ʹ-deoxycytidine (5-Aza) alleviated heart failure in rats according to medical cardiac indexes. Western blotting and qRT-PCR revealed that a conspicuous difference in the expression of <i>IRX1</i> and <i>CXCL14</i> between HF and normal cardiac cells. As a result of gene methylation, left ventricular hypertrophy and cardiac fibrosis is usually accompanied by heart failure. Moreover, is the results implied that the demethylation of <i>IRX1</i> improves heart failure <i>in vivo</i> and <i>in vitro. IRX1</i> methylation induced damaged cardiac function and even heart failure, which has important implications for HF treatment and diagnosis.
DOI: 10.6084/m9.figshare.25011562
title: Assessment of the ecological status of large lowland rivers (Sava and Tisa, Serbia) based on digital microscopic investigation of the diatom communities

description: Large lowland rivers represent an important type of ecosystem that has been under a constant anthropogenic influence (industry, thermal power plants, untreated communal water, and agriculture) for centuries, which has led to most of them no longer meeting natural reference conditions. These pressures affect diatom communities which represent a reliable bioindicator of the overall degradation of water bodies. The current study provides detailed information about benthic diatoms from the large international lowland rivers Sava and Tisa, analyzed using digital microscopy. Using the digital method and the BIIGLE 2.0 image annotation system, a total of 205 and 206 diatom taxa in the Sava and Tisa rivers were identified, belonging to 65 and 63 genera, respectively. Some of the dominant genera in the Sava River were <i>Achnanthidium</i>, <i>Cocconeis</i>, <i>Gyrosigma</i>, and <i>Navicula</i>, while in the Tisa River, mostly centric diatoms (<i>Discostella</i>, <i>Cyclotella</i>, <i>Stephanodiscus</i>) were dominant. Most of the recorded species are alkaliphilic and characteristic of running waters with high trophic conditions. The presence of halophilic taxa was also noted (e.g. <i>Bacillaria paxilifera</i>, <i>Tryblionella</i> species, <i>Nitzschia clausii</i>, <i>Navicula salinarum</i>). These taxa are sensitive indicators of even short-term changes in lowland lotic ecosystems characterized by elevated conductivity. The diatom indices showed very consistent ecological status, mainly moderate in terms of the general pollution index IPS, and poor to bad ecological status according to trophic diatom indices (Rott TI and TDI).
DOI: 10.6084/m9.figshare.25011562.v1
title: Assessment of the ecological status of large lowland rivers (Sava and Tisa, Serbia) based on digital microscopic investigation of the diatom communities

description: Large lowland rivers represent an important type of ecosystem that has been under a constant anthropogenic influence (industry, thermal power plants, untreated communal water, and agriculture) for centuries, which has led to most of them no longer meeting natural reference conditions. These pressures affect diatom communities which represent a reliable bioindicator of the overall degradation of water bodies. The current study provides detailed information about benthic diatoms from the large international lowland rivers Sava and Tisa, analyzed using digital microscopy. Using the digital method and the BIIGLE 2.0 image annotation system, a total of 205 and 206 diatom taxa in the Sava and Tisa rivers were identified, belonging to 65 and 63 genera, respectively. Some of the dominant genera in the Sava River were <i>Achnanthidium</i>, <i>Cocconeis</i>, <i>Gyrosigma</i>, and <i>Navicula</i>, while in the Tisa River, mostly centric diatoms (<i>Discostella</i>, <i>Cyclotella</i>, <i>Stephanodiscus</i>) were dominant. Most of the recorded species are alkaliphilic and characteristic of running waters with high trophic conditions. The presence of halophilic taxa was also noted (e.g. <i>Bacillaria paxilifera</i>, <i>Tryblionella</i> species, <i>Nitzschia clausii</i>, <i>Navicula salinarum</i>). These taxa are sensitive indicators of even short-term changes in lowland lotic ecosystems characterized by elevated conductivity. The diatom indices showed very consistent ecological status, mainly moderate in terms of the general pollution index IPS, and poor to bad ecological status according to trophic diatom indices (Rott TI and TDI).
DOI: 10.25502/1qa0-sc25/d
title: RCI veg seedling trial data.Murange, Kenya season 2 2023
DOI: 10.5066/p13b46b8
title: Louisiana Outer Coast Restoration Project – 2017 habitat map, Chenier Ronquille

description: This data release includes 2017 data for the Louisiana Outer Coast Restoration Project for Chenier Ronquille. Specifically, this data release includes a detailed habitat map, general habitat map, and georeferenced imagery. These habitat maps are developed using the methods and classification scheme from Louisiana Coastal Protection and Restoration Authority’s (CPRA) Barrier Island Comprehensive Monitoring (BICM) program. For more details on BICM habitat classes, see the Entity and Attribute Information section of the metadata. Please consult the accompanying readME.txt file for information and recommendations on the contents of this dataset (that is, dataset and recommended symbology). For more information about BICM habitat mapping, see Enwright and others (2020).
References:
Enwright, N.M., SooHoo, W.M., Dugas, J.L., Conzelmann, C.P., Laurenzano, C., Lee, D.M., Mouton, K., and Stelly, S.J., 2020, Louisiana Barrier Island Comprehensive Monitoring Program—Mapping habitats in beach, dune, and intertidal environments along the Louisiana Gulf of Mexico shoreline, 2008 and 2015–16: U.S. Geological Survey Open-File Report 2020–1030, 57 p., https://doi.org/10.3133/ofr20201030.
DOI: 10.6084/m9.figshare.19980630.v1
title: Additional file 2 of TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma

description: Additional file 2.
DOI: 10.6084/m9.figshare.21556938.v1
title: INFLUENCE OF UPPER BODY STRETCHING EXERCISES ON SHOT PUT

description: ABSTRACT Introduction The technique in the shot put and the ability in the throwing stage are two important factors that determine the ability of athletes. Qualified experts and coaches attach great importance to training and research on the ability of the throwing stage and the ability to throw. Objective Compare gravity load training and single incremental load training through practical means, analyzing the impacts on throwing ability in athletes. Methods The self-assessment method was used to conduct the comparative experiment on different forms of strength training in 20 college students. The experimental scheme adopts the single incremental load strength training, and the control scheme adopts the traditional barbell training. Results : After the experiment, the hand angle of group I was significantly higher than that of group II (P &lt; 0.05); after the experiment, the shoulder angle of group I was significantly higher than that of group II (P &lt; 0.05); after the experiment, the performance of the seated shot placed in group I was significantly higher than that of group II (P &lt; 0.05), and there was no significant difference in the standing performance (P &gt; 0.05). Conclusion Single incremental load training can significantly improve the throwing ability of shot put athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.5281/zenodo.10629504
title: Data Set: Factores que influyen en la comprensibilidad de Modelos BPMN

description: Data set de estudio empírico para la evaluación de factores de comprensibilidad en modelos BPMN.
DOI: 10.6084/m9.figshare.21556960
title: Wheat seed germination based on α-amylase activity to study promoting mechanism of Bacillus subtilis QM3

description: Abstract: The mechanism of promoting wheat seed germination by Bacillus subtilis has been paid great attention by many scholars. The germination rate and α-amylase activity of wheat seeds were significantly increased after germinating with Bacillus subtilis QM3 in this paper. Inhibitor and promoter of α-amylase were used to study relationship between bacteria and α-amylase. Compared with inhibitor group (10 mmol.L-1 EDTA), α-amylase activity of seeds treated by B. subtilis QM3 (106 CFU.mL-1) increased by 19.8%. It indicates that the inhibition has been alleviated. Similarly, α-amylase activity of co-treated group (2 mmol.L-1 CaCl2 and 106 CFU.mL-1 B. subtilis QM3) was higher than that of the promoter alone, reaching 14.9%. Furthermore, the results of α-amylase isozyme electrophoresis showed that there were three isozyme types in the gels, and the expression of α-amylase isoenzyme was significantly increased after treatment with B. subtilis QM3 (106 CFUmL.-1), which was reflected in the width and brightness of band mainly, especially band Cα. In addition, germination rate, α-amylase activity and isozyme electrophoresis of other three kinds of wheat seeds were also tested and similar results were obtained. Therefore, one of the possible mechanisms by which B. subtilis QM3 promotes seed germination is as a potential exogenous factor that can enhance activity and expression of α-amylase.
DOI: 10.6084/m9.figshare.21556990.v1
title: IMPROVING EXPLOSIVE BODY CAPACITY IN FEMALE SHORT TRACK SPEED SKATERS

description: ABSTRACT Introduction The peculiar characteristics of short track speed skating should be integrated into the psychology of competitions; it is considered that elite athletes engaged in this particular sport should have a healthy psychic condition. Objective Investigate the explosive power of female speed skaters in short track speed skating. Methods 10 key athletes from the national short track speed skating team were selected, and explosive power was tested by T-test, hexagonal test, and pro sensitivity test. Data analysis was performed using an independent sample t-test, differences in the results of related test indicators between groups were analyzed, and repeated measures analysis of variance was used. Results During the explosive kick phase, knee extension speed increased linearly from 210°/S to 600°/S, and hip extension speed increased linearly from 200°/S to 400°/S. Conclusion The development of muscle group strength and explosive power during training often shows differences in the degree of contraction, which is related to the arrangement of training methods. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.22602149
title: Additional file 3 of X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study

description: Additional file 3: Table S2. XWAS Meta-analysis Top ACE2 Xp22.2 Variants
DOI: 10.5281/zenodo.10629503
title: Data Set: Factores que influyen en la comprensibilidad de Modelos BPMN

description: Data set de estudio empírico para la evaluación de factores de comprensibilidad en modelos BPMN.
DOI: 10.5281/zenodo.10629663
title: Data Set: Factores que influyen en la comprensibilidad de Modelos BPMN

description: Data set de estudio empírico para la evaluación de factores de comprensibilidad en modelos BPMN.
DOI: 10.6084/m9.figshare.22602107.v1
title: Additional file 2 of StackCirRNAPred: computational classification of long circRNA from other lncRNA based on stacking strategy

description: Additional file 2: Table S1. The Optimal Feature Set of 110-dimensional.
DOI: 10.5281/zenodo.10630633
title: Base de datos- IJRDM

description: Base de datos utilizada para la elaboración del trabajo:

Marín-García, A., Gil-Saura, I., Ruiz-Molina, M.-E. and Fuentes-Blasco, M. (2023), "Relationship sustainability-store equity across segments of retail customers", International Journal of Retail & Distribution Management, Vol. 51 No. 3, pp. 366-385. https://doi.org/10.1108/IJRDM-12-2021-0585
DOI: 10.5281/zenodo.10630632
title: Base de datos- IJRDM

description: Base de datos utilizada para la elaboración del trabajo:

Marín-García, A., Gil-Saura, I., Ruiz-Molina, M.-E. and Fuentes-Blasco, M. (2023), "Relationship sustainability-store equity across segments of retail customers", International Journal of Retail & Distribution Management, Vol. 51 No. 3, pp. 366-385. https://doi.org/10.1108/IJRDM-12-2021-0585
DOI: 10.6084/m9.figshare.14741218
title: Additional file 2 of ITRAQ-based quantitative proteomics reveals the proteome profiles of MDBK cells infected with bovine viral diarrhea virus

description: Additional file 2: Table S2. The results of significantly differentially expressed proteins (p &lt; 0.05 and FC &gt; 1.5 or &lt; 0.67 ([fold change, FC]) in the BVDV NADL-infected MDBK cells at 12, 24, and 48 h after infection using iTRAQ technology.
DOI: 10.6084/m9.figshare.14741218.v1
title: Additional file 2 of ITRAQ-based quantitative proteomics reveals the proteome profiles of MDBK cells infected with bovine viral diarrhea virus

description: Additional file 2: Table S2. The results of significantly differentially expressed proteins (p &lt; 0.05 and FC &gt; 1.5 or &lt; 0.67 ([fold change, FC]) in the BVDV NADL-infected MDBK cells at 12, 24, and 48 h after infection using iTRAQ technology.
DOI: 10.6084/m9.figshare.24182583
title: Peripheral blood MicroRNAs as biomarkers of schizophrenia: expectations from a meta-analysis that combines deep learning methods

description: This study aimed at identifying reliable differentially expressed miRNAs (DEMs) for schizophrenia in blood <i>via</i> meta-analyses combined with deep learning methods. First, we meta-analysed published DEMs. Then, we enriched the pool of schizophrenia-associated miRNAs by applying two computational learning methods to identify candidate biomarkers and verified the results in external datasets. In total, 27 DEMs were found to be statistically significant (<i>p</i> &lt; .05). Ten candidate schizophrenia-associated miRNAs were identified through computational learning methods. The diagnostic efficiency was verified on a blood-miRNA dataset (GSE54578) with a random forest (RF) model and achieved an area under the curve (AUC) of 0.83 ± 0.14. Moreover, 855 experimentally validated target genes for these candidate miRNAs were retrieved, and 11 hub genes were identified. Enrichment analysis revealed that the main functions in which the target genes were enriched were those related to cell signalling, prenatal infections, cancers, cell deaths, oxidative stress, endocrine disorders, transcription regulation, and kinase activities. The diagnostic ability of the hub genes was reflected in a comparably good average AUC of 0.77 ± 0.09 for an external dataset (GSE38484). A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.
DOI: 10.6084/m9.figshare.24182583.v1
title: Peripheral blood MicroRNAs as biomarkers of schizophrenia: expectations from a meta-analysis that combines deep learning methods

description: This study aimed at identifying reliable differentially expressed miRNAs (DEMs) for schizophrenia in blood <i>via</i> meta-analyses combined with deep learning methods. First, we meta-analysed published DEMs. Then, we enriched the pool of schizophrenia-associated miRNAs by applying two computational learning methods to identify candidate biomarkers and verified the results in external datasets. In total, 27 DEMs were found to be statistically significant (<i>p</i> &lt; .05). Ten candidate schizophrenia-associated miRNAs were identified through computational learning methods. The diagnostic efficiency was verified on a blood-miRNA dataset (GSE54578) with a random forest (RF) model and achieved an area under the curve (AUC) of 0.83 ± 0.14. Moreover, 855 experimentally validated target genes for these candidate miRNAs were retrieved, and 11 hub genes were identified. Enrichment analysis revealed that the main functions in which the target genes were enriched were those related to cell signalling, prenatal infections, cancers, cell deaths, oxidative stress, endocrine disorders, transcription regulation, and kinase activities. The diagnostic ability of the hub genes was reflected in a comparably good average AUC of 0.77 ± 0.09 for an external dataset (GSE38484). A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.