cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3394639.v139
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers were observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003).These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, but other than on the surfaces of metabolically weak red cells, appear transiently to be completed by graft-phenotype-specific protective glycosylation and recover when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v140
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur in successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (Bastani, 2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous decrease of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on the surfaces of metabolically weak red cells, appear to be completed by graft-phenotype-specific protective glycosylation and may only recover when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v141
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur in successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (Bastani, 2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous decrease of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on the surfaces of metabolically weak red cells, appear to be completed by graft-phenotype-specific protective glycosylation and may only recover when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v142
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur in successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (Bastani, 2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous decrease of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on the surfaces of metabolically weak red cells, appear to be completed by graft-phenotype-specific protective glycosylation and may only recover when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v143
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur in successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (Bastani, 2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous decrease of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on the surfaces of metabolically weak red cells, appear to be completed by graft-phenotype-specific protective glycosylation and may only recover when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v144
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur after successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani ( 2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous decrease of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on the surfaces of metabolically weak red cells, they appear to be completed by graft-phenotype-specific protective glycosylation, and may recover when the graft-intrinsic enzymatic power and supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v145
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur after successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous fall of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena occurring in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on red cell surfaces, they appear to be completed by graft-phenotype-specific protective glycosylation, and depending on the type of graft may recover when the graft-intrinsic enzymatic power and/or supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v146
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur after successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous fall of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena occurring in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on red cell surfaces, they appear to be completed by graft-phenotype-specific protective glycosylation, and depending on the type of graft may recover when the graft-intrinsic enzymatic power and/or supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v147
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991) (Della-Guardia et al., 2008) and does not occur after successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous fall of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena occurring in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on red cell surfaces, they appear to be completed by graft-phenotype-specific protective glycosylation, and depending on the type of graft may recover when the graft-intrinsic enzymatic power and/or supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394639.v148
title: Spontaneous and therapeutic glycosidic accommodation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

description: In contrast to non-nucleated ABO(H) red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs; it is extremely rare in liver transplantations (Adams, 1991; Della-Guardia et al., 2008) and does not occur after successful bone marrow engraftment (Takahashi, 2005). Moreover, a case of transient, selective disappearance of pre-existing donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014)<i> </i>such transient decrease of donor-specific HLA-antibodies is not uncommon after incompatible liver transplantation. Treatment of pure red cell aplasia (PRCA) with ABO incompatible RBC, after ABO blood group incompatible hematopoietic stem cell transplantation, was followed by spontaneous fall of isoagglutinin levels in several individuals (Stussi et al. 2009). In addition, an exponential fall in both anti-A/B reactive IgM and IgG titers was observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003). These phenomena occurring in “major incompatibilities” most likely reflect a complex mechanism, in which pre-existing anti-graft-reactive immunoglobulins of the host are adsorbed on complementary sites on the cell surfaces of the graft, but unlike on red cell surfaces, they appear to be completed by graft-phenotype-specific protective glycosylation, and depending on the type of graft may recover when the graft-intrinsic enzymatic power and/or supply of specific substrates are exhausted.
DOI: 10.6084/m9.figshare.3394594
title: Characterization of urge to cough and cough symptoms associated with the common cold: results of a US internet survey

description: <b>Objectives</b>: Our knowledge of cough physiology is limited despite years of study. Even less is known about the sensation of urge to cough. Given that limited clinical data are available about urge to cough and cough attributes during a common cold, we sought to gain insights into experiences and perceptions related to these symptoms. <b>Methods</b>: An internet survey consisting of 51 questions was fielded in the United States. Eligible survey participants included men and women aged 18 years and older who had suffered from a cold with cough within the three months preceding the survey. Participants who confirmed suffering from recurrent cough, asthma, chronic bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, or gastrointestinal reflux were excluded. <b>Results</b>: Of 19,530 initial respondents, 8011 had a cold in the past three months. Of these, 6484 (81%) had experienced cough symptoms; 2708 respondents with cough due to cold and no exclusionary condition made up the analysis sample. Most respondents (62%) reported that cough developed one to two days after the onset of cold symptoms, and 45% felt that cough worsened their other cold symptoms. In 69% of respondents, cough outlasted other cold symptoms. Urge to cough was reported by 98% of respondents, and among these respondents, 64% described it as uncontrollable and 65% rated severity as moderate. More than half of respondents (57%) considered the sensation of urge to cough and the act of coughing as equally bothersome. Although urge to cough and inability to control cough were the most bothersome aspects of cough due to cold, few (&lt;20%) respondents asked healthcare providers for treatment recommendations. <b>Conclusion</b>: Symptoms of urge to cough and cough are common and have a significant impact on cold sufferers. Understanding attributes of these symptoms may provide insights for effective management and the development of novel treatment strategies.
DOI: 10.6084/m9.figshare.3394594.v1
title: Characterization of urge to cough and cough symptoms associated with the common cold: results of a US internet survey

description: <b>Objectives</b>: Our knowledge of cough physiology is limited despite years of study. Even less is known about the sensation of urge to cough. Given that limited clinical data are available about urge to cough and cough attributes during a common cold, we sought to gain insights into experiences and perceptions related to these symptoms. <b>Methods</b>: An internet survey consisting of 51 questions was fielded in the United States. Eligible survey participants included men and women aged 18 years and older who had suffered from a cold with cough within the three months preceding the survey. Participants who confirmed suffering from recurrent cough, asthma, chronic bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, or gastrointestinal reflux were excluded. <b>Results</b>: Of 19,530 initial respondents, 8011 had a cold in the past three months. Of these, 6484 (81%) had experienced cough symptoms; 2708 respondents with cough due to cold and no exclusionary condition made up the analysis sample. Most respondents (62%) reported that cough developed one to two days after the onset of cold symptoms, and 45% felt that cough worsened their other cold symptoms. In 69% of respondents, cough outlasted other cold symptoms. Urge to cough was reported by 98% of respondents, and among these respondents, 64% described it as uncontrollable and 65% rated severity as moderate. More than half of respondents (57%) considered the sensation of urge to cough and the act of coughing as equally bothersome. Although urge to cough and inability to control cough were the most bothersome aspects of cough due to cold, few (&lt;20%) respondents asked healthcare providers for treatment recommendations. <b>Conclusion</b>: Symptoms of urge to cough and cough are common and have a significant impact on cold sufferers. Understanding attributes of these symptoms may provide insights for effective management and the development of novel treatment strategies.