DOI: 10.5281/zenodo.18674364
title: Multi-ancestry GWAS of severe pregnancy nausea and vomiting - MoBa analysis

description: Contains the GWAS meta analysis summary statistics of the analysis of severe pregnancy nausea and vomiting in the Norwegian Mother, Father and Child (MoBa) cohort study, included in the folowing publication.

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity

Marlena Fejzo, Xinran Wang, Qing Tan, Julia Zöllner, Natàlia Pujol-Gualdo, Triin Laisk, Estonian Biobank Research Team, Sarah Finer, David A. van Heel, Genes & Health Research Team, Ben Brumpton, Laxmi Bhatta, Kristian Hveem, Elizabeth A. Jasper, Digna R. Velez Edwards, Jacklyn N. Hellwege, Todd Edwards, Gail P. Jarvik, Yuan Luo, Atlas Khan, Kimber MacGibbon, Yuan Gao, Gaoxiang Ge, Inna Averbukh, Erin Soon, Michael Angelo, Per Magnus, Stefan Johansson, Pål R. Njølstad, Artem Kim, Steven Gazal, Marc Vaudel, Chang Shu, Nicholas Mancuso. Nature Genetics, (in press), 2026.

 



Content

GWAS summary statistics are provided for association against the genomes of the father, mother, and child for the following phenotypes.






Hyperemesis gravidarum (hyperemesis_gravidarum_vs_all.tar.gz): GWAS of participants of pregnancies where the mother reported being hospitalized due to prolonged nausea and vomiting versus all other pregnancies.




Hyperemesis gravidarum vs. no nausea vomiting (hyperemesis_gravidarum_vs_no_nausea_vomiting.tar.gz): GWAS of participants of pregnancies where the mother reported being hospitalized due to prolonged nausea and vomiting versus mothers who did not report nausea or vomiting as control.




Nausea vomiting during pregnancy (nausea_vomiting.tar.gz): GWAS of participants of pregnancies where the mother reported suffering from nausea or vomiting versus mothers who did not report nausea or vomiting as control.




Nausea vomiting during pregnancy and hospitalization (nausea_vomiting_strength.tar.gz): GWAS of participants of pregnancies encoding {0: mothers who did not report nausea or vomiting, 1: mothers reported nausea or vomiting, 2: mothers reported being hospitalized}.




Nausea before week 4 (nausea_before_4w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea before week 4.




Vomiting before week 4 (vomiting_before_4w.tar.gz): GWAS of participants of pregnancies where the mother reported vomiting before week 4.




Nausea vomiting before week 4 (nausea_vomiting_before_4w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting before week 4.




Nausea vomiting before week 8 (nausea_vomiting_before_8w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting before week 8.




Nausea vomiting week 5 to 8 (nausea_vomiting_5w_8w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Nausea vomiting week 9 to 12 (nausea_vomiting_9w_12w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Nausea vomiting week 13 to 15 (nausea_vomiting_13w_15w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Nausea vomiting week 13 to 16 (long_term_nausea_vomiting_13w_16w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Nausea vomiting week 17 to 20 (long_term_nausea_vomiting_17w_20w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Nausea vomiting week 21 to 24 (long_term_nausea_vomiting_21w_24w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Nausea vomiting week 25 to 29 (long_term_nausea_vomiting_25w_29w.tar.gz): GWAS of participants of pregnancies where the mother reported nausea vomiting stratified by week.




Long-term nausea vomiting after week 17 (long_term_nausea_vomiting_after_17w.tar.gz): GWAS of participants of pregnancies where the mother reported suffering from long-term nausea vomiting after week 17.




Long-term nausea vomiting after week 21 (long_term_nausea_vomiting_after_21w.tar.gz): GWAS of participants of pregnancies where the mother reported suffering from long-term nausea vomiting after week 21.




Long-term nausea vomiting after week 25 (long_term_nausea_vomiting_after_25w.tar.gz): GWAS of participants of pregnancies where the mother reported suffering from long-term nausea vomiting after week 25.




Long-term nausea vomiting after week 29 (long_term_nausea_vomiting_after_29w.tar.gz): GWAS of participants of pregnancies where the mother reported suffering from long-term nausea vomiting after week 29.




Long-term nausea vomiting after week 13 (long_term_nausea_vomiting_after_13w.tar.gz): GWAS of participants of pregnancies where the mother reported suffering from long-term nausea vomiting after week 13.




Vomiting start (vomiting_week_from.tar.gz): GWAS of participants of pregnancies against the week where mothers reported beginning to suffer from vomiting.




Vomiting end (vomiting_week_to.tar.gz): GWAS of participants of pregnancies against the week where mothers reported ending to suffer from vomiting.




Vomiting duration (vomiting_duration.tar.gz): GWAS of participants of pregnancies against the duration in weeks where mothers reported suffering from vomiting.