cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13359056
title: Supplementary Material for: Duration of Oral Antibiotics Administration for Cetuximab-Induced Acneiform Eruption

description: <b><i>Background:</i></b> Acneiform eruption is the most common cutaneous adverse event associated with cetuximab. As it can affect quality of life and adversely affect chemotherapy schedule, additional medical care is required. <b><i>Objectives:</i></b> To investigate the adherence to and the duration of antibiotic administration to treat cetuximab-induced acneiform eruption. <b><i>Methods:</i></b> Medical data of patients who were referred to the Department of Dermatology were reviewed from January 2013 to June 2018. Dermatologists assessed the severity of acneiform eruption and prescribed tetracycline-class antibiotics according to the severity every 2 or 4 weeks. We investigated the duration and amount of oral antibiotic administration and analyzed the factors that may affect the control of acneiform eruption statistically. <b><i>Results:</i></b> A total of 207 of 267 patients referred to the Department of Dermatology showed acneiform eruption; 124 patients were treated with minocycline, 34 patients with doxycycline, 27 patients with both, and 22 patients with topical agents. The mean duration of oral antibiotic medication was 82.7 days. A statistical analysis of the factors that prolonged the use of antibiotics for more than 90 days showed that male and younger age were risk factors. Shorter time interval from starting cetuximab to starting antibiotics was associated with longer duration of antibiotic use, statistically. <b><i>Conclusions:</i></b> Cetuximab-induced acneiform eruption can be well controlled with tetracycline-class antibiotics in about 3 months. It can last longer in male and younger patients. The sooner and the more severe it appears, the longer it can last.
DOI: 10.6084/m9.figshare.13359056.v1
title: Supplementary Material for: Duration of Oral Antibiotics Administration for Cetuximab-Induced Acneiform Eruption

description: <b><i>Background:</i></b> Acneiform eruption is the most common cutaneous adverse event associated with cetuximab. As it can affect quality of life and adversely affect chemotherapy schedule, additional medical care is required. <b><i>Objectives:</i></b> To investigate the adherence to and the duration of antibiotic administration to treat cetuximab-induced acneiform eruption. <b><i>Methods:</i></b> Medical data of patients who were referred to the Department of Dermatology were reviewed from January 2013 to June 2018. Dermatologists assessed the severity of acneiform eruption and prescribed tetracycline-class antibiotics according to the severity every 2 or 4 weeks. We investigated the duration and amount of oral antibiotic administration and analyzed the factors that may affect the control of acneiform eruption statistically. <b><i>Results:</i></b> A total of 207 of 267 patients referred to the Department of Dermatology showed acneiform eruption; 124 patients were treated with minocycline, 34 patients with doxycycline, 27 patients with both, and 22 patients with topical agents. The mean duration of oral antibiotic medication was 82.7 days. A statistical analysis of the factors that prolonged the use of antibiotics for more than 90 days showed that male and younger age were risk factors. Shorter time interval from starting cetuximab to starting antibiotics was associated with longer duration of antibiotic use, statistically. <b><i>Conclusions:</i></b> Cetuximab-induced acneiform eruption can be well controlled with tetracycline-class antibiotics in about 3 months. It can last longer in male and younger patients. The sooner and the more severe it appears, the longer it can last.
DOI: 10.21258/1498954
title: Inventaire forestier national suisse - Tableau no 897483
DOI: 10.21258/1506424
title: Inventaire forestier national suisse - Tableau no 892015
DOI: 10.21258/1516535
title: Inventaire forestier national suisse - Tableau no 898171
DOI: 10.21258/1501534
title: Inventaire forestier national suisse - Tableau no 893034
DOI: 10.21258/1489600
title: Inventaire forestier national suisse - Tableau no 892907
DOI: 10.21258/1518335
title: Inventaire forestier national suisse - Tableau no 898248
DOI: 10.21258/1488155
title: Inventaire forestier national suisse - Tableau no 899234
DOI: 10.21258/1504946
title: Inventaire forestier national suisse - Tableau no 902263
DOI: 10.21258/1521437
title: Inventaire forestier national suisse - Tableau no 899482
DOI: 10.21258/1509071
title: Inventaire forestier national suisse - Tableau no 892996
DOI: 10.21258/1482824
title: Inventaire forestier national suisse - Tableau no 898056
DOI: 10.25345/c5mv2g
title: MassIVE MSV000086572 - Motif-dependent Synthetic Immune Receptor Interactome Profiling by Photoaffinity Proteomics
title: The identification of tyrosine phosphorylation-dependent interactome of immune receptors is crucial for the understanding of signal pathways involved in immune signaling and immunotherapy. However, identifying motif-specific interactome for each tyrosine phosphorylation site commonly found on these multi-phosphorylated membrane proteins remains challenging. Here we describe a photoaffinity-based chemical proteomic approach to dissect motif-specific cytoplasmic interactome of the critical immune coreceptor CD28. Various full-length CD28 cytoplasmic tail (CD28cyto) with different combination of three phosphotyrosine (pY) motifs and selectively replaced Photo-Methionine (Photo-Met) were chemically synthesized. Taking advantage of the covalent bonds formed by Photo-Met with short space arm, pY motif-dependent and direct CD28cyto interactome was selectively captured and accurately characterized by label-free quantitative proteomics. The chemical proteomic analysis well recapitulated reported CD28cyto interacting proteins to pY191 and pY209 motifs. Importantly, we defined the stand-alone interaction of phospholipase PLCG1 to Y191 motif with enhanced affinity to the sequence neighboring the transmembrane domain. Furthermore, we explored the interactome of previously undefined pY218 motif and found that a critical kinase PKC theta strongly and directly associated with pY218 through its C2 domain.
DOI: 10.21258/1499802
title: Inventaire forestier national suisse - Tableau no 899200
DOI: 10.21258/1488937
title: Inventaire forestier national suisse - Tableau no 899613
DOI: 10.21258/1491243
title: Inventaire forestier national suisse - Tableau no 902047
DOI: 10.21258/1492584
title: Inventaire forestier national suisse - Tableau no 898793
DOI: 10.21258/1506220
title: Inventaire forestier national suisse - Tableau no 897493
DOI: 10.21258/1504594
title: Inventaire forestier national suisse - Tableau no 891834
DOI: 10.21258/1528985
title: Inventaire forestier national suisse - Tableau no 899291
DOI: 10.21258/1511380
title: Inventaire forestier national suisse - Tableau no 897896
DOI: 10.21258/1481839
title: Inventaire forestier national suisse - Tableau no 897065
DOI: 10.21258/1505225
title: Inventaire forestier national suisse - Tableau no 897302
DOI: 10.6084/m9.figshare.11316281
title: Dataset and code: Disentangling the groundwater response to Earth and atmospheric tides to improve subsurface characterisation

description: This repository provides the python code and dataset for the paper entitled "Technical Note: Disentangling the groundwater response to Earth and atmospheric tides to improve subsurface characterisation" published in the journal "Hydrology and Earth System Sciences".
DOI: 10.21258/1489430
title: Inventaire forestier national suisse - Tableau no 898010
DOI: 10.21258/1494104
title: Inventaire forestier national suisse - Tableau no 898999
DOI: 10.5281/zenodo.4244313
title: Toxicological Effect and Risk Assessment (TERA) Knowledge Graph

description: The Toxicological Effect and Risk Assessment (TERA) Knowledge Graph is based on chemical effect data from U.S. EPA ECOTOX. This data is aligned to non-proprietary identifiers using ontology alignment tools and external sources (eg. wikidata). This enables the use of external chemical knowledge graphs (eg. ChEBI, PubChem, Mesh, "Courtesy of the U.S. National Library of Medicine"). This data set also included an aggregated (into a knowledge graph) of the NCBI taxonomy and Encyclopedia of Life traits data. Linking ECOTOX to external sources enables the extrapolation of effect data, which can extend the reach of ecological risk assessment and limit laboratory experiments. The construction and APIs to facilitate access can be found at https://github.com/NIVA-Knowledge-Graph/TERA LICENCES:<br> <strong>EOL</strong>: Various Creative Commons (CC),<br> <strong>NCBI</strong>: Creative Commons CC0 1.0 Universal (CC0 1.0),<br> <strong>ECOTOX</strong>: No restrictions,<br> <strong>PubChem</strong>: Open Data Commons Open Database License, <br> <strong>ChEMBL</strong>: CC Attribution,<br> <strong>MeSH</strong>: Open<em>, Courtesy of the U.S. National Library of Medicine,</em><br> <strong>Wikidata</strong><em>: CC0 1.0.</em>
description: {"references": ["Myklebust, Erik B. et. al. Enabling Semantic Data Access for Toxicological Risk Assessment (2019). CoRR abs/1908.10128"]}
DOI: 10.5281/zenodo.3559865
title: Toxicological Effect and Risk Assessment (TERA) Knowledge Graph

description: The Toxicological Effect and Risk Assessment (TERA) Knowledge Graph is based on chemical effect data from U.S. EPA ECOTOX. This data is aligned to non-proprietary identifiers using ontology alignment tools and external sources (eg. wikidata). This enables the use of external chemical knowledge graphs (eg. ChEBI, PubChem, Mesh, "Courtesy of the U.S. National Library of Medicine"). This data set also included an aggregated (into a knowledge graph) of the NCBI taxonomy and Encyclopedia of Life traits data. Linking ECOTOX to external sources enables the extrapolation of effect data, which can extend the reach of ecological risk assessment and limit laboratory experiments. The construction and APIs to facilitate access can be found at https://github.com/NIVA-Knowledge-Graph/TERA LICENCES:<br> <strong>EOL</strong>: Various Creative Commons (CC),<br> <strong>NCBI</strong>: Creative Commons CC0 1.0 Universal (CC0 1.0),<br> <strong>ECOTOX</strong>: No restrictions,<br> <strong>PubChem</strong>: Open Data Commons Open Database License, <br> <strong>ChEMBL</strong>: CC Attribution,<br> <strong>MeSH</strong>: Open<em>, Courtesy of the U.S. National Library of Medicine,</em><br> <strong>Wikidata</strong><em>: CC0 1.0.</em>
description: {"references": ["Myklebust, Erik B. et. al. Enabling Semantic Data Access for Toxicological Risk Assessment (2019). CoRR abs/1908.10128"]}
DOI: 10.5281/zenodo.4314280
title: SIRT1 activation attenuates the cardiac dysfunction induced by endothelial cell-specific deletion of CRIF1

description: Figure 1 (a) SIRT1 mRNA levels in the heart tissues were quantified using qPCR. (b) SIRT1 deacetylase activity in heart homogenates. (c) SIRT1 protein expression in the heart tissues were determined by western blotting. α-tubulin was used as the internal control. Densitometric analysis of SIRT1 protein levels is shown. All data are presented as means ± SEM of three independent experiments. *p &lt; 0.05 vs. WT mice. #p &lt; 0.05 vs. CRIF1 EKO mice.
DOI: 10.5281/zenodo.4314279
title: SIRT1 activation attenuates the cardiac dysfunction induced by endothelial cell-specific deletion of CRIF1

description: Figure 1 (a) SIRT1 mRNA levels in the heart tissues were quantified using qPCR. (b) SIRT1 deacetylase activity in heart homogenates. (c) SIRT1 protein expression in the heart tissues were determined by western blotting. α-tubulin was used as the internal control. Densitometric analysis of SIRT1 protein levels is shown. All data are presented as means ± SEM of three independent experiments. *p &lt; 0.05 vs. WT mice. #p &lt; 0.05 vs. CRIF1 EKO mice.
DOI: 10.21258/1515350
title: Inventaire forestier national suisse - Tableau no 891676
DOI: 10.21258/1501820
title: Inventaire forestier national suisse - Tableau no 891970
DOI: 10.21258/1484621
title: Inventaire forestier national suisse - Tableau no 899021
DOI: 10.21258/1479928
title: Inventaire forestier national suisse - Tableau no 893045
DOI: 10.21258/1502003
title: Inventaire forestier national suisse - Tableau no 891705
DOI: 10.6084/m9.figshare.13341236.v1
title: Supplementary Material for: Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome – An International Consensus Statement

description: The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a “logbook” for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies.
DOI: 10.21258/1510441
title: Inventaire forestier national suisse - Tableau no 899653
DOI: 10.17632/ktx4cj55pn.1
title: Radiographic Dataset for VHS determination learning process

description: The data collected at baseline include latero lateral thoracic radiographic images of canine patients. This data was collected in 2019- 2020. The number of patients is 156 canine patients. The dataset consists of 156 radiographic images . The images are in PNG format. Materials and Methods Radiographic images were taken and collected at the Small Animal Veterinary Teaching Hospital, Veterinary Sciences Reasearch Institute, Autonomous University of Baja California. The image collection and classification was performed between 2019- 2020. The instrument used in the radiographic image adquisition process is Universal AV Choice X-Ray System and Rayence XMARU 1417PGA-PCA 14×17″ cassette digital detector (DR system). In the development of radiographic studies, techniques were used in the range of the following parameters using a high peak kilovoltage (kVp 70-80) and low milliampere-second technique (mA 200, ms 10-40) equivalent to 2-8 mAs. This technique allows for latitude (long gray scale) images, which are important when evaluating the structures of the thorax. For a right and left lateral image, patients were positioned on the table with the dependent side down. Relevant anatomical structures in the determination of VHS were included. The laterals beam projections extended from the cranial margin of the manubrium to the caudo-dorsal margin of the lung margin/diaphragmatic crus. The sternum of the patient was included so as not to exclude vital anatomy. The number of images collected initially was 628 and were stored in a DICOM format. DICOM images were converted to PNG format by using a DICOM converter application included on the acquisition software. After performing classification and preprocessing, the number of images included in the final dataset was reduced to 152 representative images. All images were cropped to different sizes to remove unused and unimportant boundaries from the images using fast photo crop. As the original images contain confidential patient information not relevant for the overall educational purpose, the data was anonymized by removing all fields that would enable patient identification. The original VHS measurement was not included in the image because they may affect the output results of the training process.
DOI: 10.21258/1515878
title: Inventaire forestier national suisse - Tableau no 897590
DOI: 10.21258/1503499
title: Inventaire forestier national suisse - Tableau no 897635
DOI: 10.21258/1507684
title: Inventaire forestier national suisse - Tableau no 897884
DOI: 10.21258/1500998
title: Inventaire forestier national suisse - Tableau no 902272
DOI: 10.21258/1502667
title: Inventaire forestier national suisse - Tableau no 897953
DOI: 10.21258/1508403
title: Inventaire forestier national suisse - Tableau no 891713
DOI: 10.21258/1495741
title: Inventaire forestier national suisse - Tableau no 902121
DOI: 10.25502/8kf1-6y77/d
title: Phenology of Fopius arisanus

description: Fopius arisanus (Sonan), a koinobiont solitary egg-pupal endoparasitoid of numerous tephritid fruit fly specie, was recently introduced into Africa for the control of the Oriental fruit fly, Bactrocera dorsalis (Hendel). In this study, life-table data of F. arisanus were generated under laboratory conditions at six constant temperatures (15, 20, 25, 30, 28 and 35 °C; 75% RH, L12:D12 photoperiod) on Bactrocera dorsalis. Several non-linear functions were fitted to model species development, mortality, longevity and oviposition using the Insect Life Cycle Modeling software. The established phenology models were stochastically simulated at fluctuating temperatures to estimate the life table parameters. F. arisanus completed development from egg to adult at all the temperatures tested except at 35 °C. Mean developmental time from egg to adult was inversely proportional to the temperature. The minimum temperature threshold (Tmin) from egg to adult was 8.15 °C, while the maximum temperature threshold (Tmax) was estimated at 34.2 °C. The optimal temperature for immature stages survival was predicted for 20 to 30 °C. The optimum fecundity estimated was 251 eggs/female at 22 °C. Following the stochastic simulations, the Humid Forest with Bimodal Rainfall of Cameroon presented suitable thermal conditions for potential population growth of F. arisanus. The present study shows the importance of temperature on the demographic parameters of F. arisanus. Effect of the difference in thermal requirements between B. dorsalis and F. arisanus on biological control under climate change scenarios is discussed.
DOI: 10.21258/1485543
title: Inventaire forestier national suisse - Tableau no 899616
DOI: 10.21258/1506290
title: Inventaire forestier national suisse - Tableau no 899207
DOI: 10.21258/1495861
title: Inventaire forestier national suisse - Tableau no 897968
DOI: 10.21258/1504635
title: Inventaire forestier national suisse - Tableau no 898006
DOI: 10.21258/1528732
title: Inventaire forestier national suisse - Tableau no 898797
DOI: 10.21258/1501003
title: Inventaire forestier national suisse - Tableau no 899669
DOI: 10.21258/1489665
title: Inventaire forestier national suisse - Tableau no 896959
DOI: 10.6084/m9.figshare.12979709.v2
title: 16S miTags from Challenger Deep metagenomes

description: 16S miTags were extracted from clean forward metagenomic reads using rna_hmm3.py.
DOI: 10.21258/1519148
title: Inventaire forestier national suisse - Tableau no 897681
DOI: 10.21258/1508181
title: Inventaire forestier national suisse - Tableau no 897957
DOI: 10.21258/1504729
title: Inventaire forestier national suisse - Tableau no 899148
DOI: 10.21258/1486674
title: Inventaire forestier national suisse - Tableau no 891925
DOI: 10.21258/1512508
title: Inventaire forestier national suisse - Tableau no 897878
DOI: 10.21258/1504872
title: Inventaire forestier national suisse - Tableau no 899508
DOI: 10.21258/1497243
title: Inventaire forestier national suisse - Tableau no 897362
DOI: 10.21258/1496573
title: Inventaire forestier national suisse - Tableau no 902281
DOI: 10.6084/m9.figshare.13359365
title: Supplementary Material for: Incidence of Stroke and Ischemic Stroke Subtypes: A Community-Based Study in Brno, Czech Republic

description: <b><i>Background:</i></b> There are few contemporary epidemiological data on stroke for Central Europe. We performed a population-based study evaluating the incidence of stroke, stroke types, and ischemic stroke (IS) subtypes in Brno, the second biggest city in the Czech Republic (CR). <b><i>Methods:</i></b> Using the National Registry of Hospitalized Patients, and hospital databases, we identified all patients hospitalized with a stroke diagnosis in Brno hospitals in 2011. For Brno residents with validated stroke diagnosis, we calculated (a) the overall incidence of hospitalized stroke, (b) incidence rates for IS, subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), and (c) incidence rates for IS subtypes. We calculated the average annual age- and sex-standardized incidence (European Standard Population and World Health Organization), to compare our results with other studies. <b><i>Results:</i></b> The overall crude incidence of stroke in Brno was 213/100,000 population. The incidence of stroke for stroke types were as follows: SAH, 6.9; ICH, 26.4; and IS, 180 cases per 100,000 population, respectively. The WHO-standardized annual stroke incidence was 107 for all strokes and 88 for IS, 14.4 for ICH, and 5 for SAH. For IS subtypes, the WHO-standardized incidence was large artery atherosclerosis 25.8, cardioembolism 27.8, lacunar 21.6, other determined etiology 6.2, and undetermined etiology 6.5 cases per 100,000 population. <b><i>Conclusions:</i></b> The stroke incidence is lower than that previously reported for the CR and Eastern Europe probably reflecting socioeconomic changes in post-communistic countries in the region. These findings could contribute to stroke prevention strategies and influence health policies.
DOI: 10.6084/m9.figshare.13359383
title: Supplementary Material for: Analysis of the Interaction between Polygenic Risk Score and Calorie Intake in Obesity in the Korean Population

description: <b><i>Introduction:</i></b> Obesity results from an imbalance in the intake and expenditure of calories that leads to lifestyle-related diseases. Although genome-wide association studies (GWAS) have revealed many obesity-related genetic factors, the interactions of these factors and calorie intake remain unknown. This study aimed to investigate interactions between calorie intake and the polygenic risk score (PRS) of BMI. <b><i>Methods:</i></b> Three cohorts, i.e., from the Korea Association REsource (KARE; <i>n</i> = 8,736), CArdioVAscular Disease Association Study (CAVAS; <i>n</i> = 9,334), and Health EXAminee (HEXA; <i>n</i> = 28,445), were used for this study. BMI-related genetic loci were selected from previous GWAS. Two scores, PRS, and association (a)PRS, were used; the former was determined from 193 single-nucleotide polymorphisms (SNPs) from 5 GWAS datasets, and the latter from 62 SNPs (potentially associated) from 3 Korean cohorts (meta-analysis, <i>p</i> &lt; 0.01). <b><i>Results:</i></b> PRS and aPRS were significantly associated with BMI in all 3 cohorts but did not exhibit a significant interaction with total calorie intake. Similar results were obtained for obesity. PRS and aPRS were significantly associated with obesity but did not show a significant interaction with total calorie intake. We further analyzed the interaction with protein, fat, and carbohydrate intake. The results were similar to those for total calorie intake, with PRS and aPRS found to not be associated with the interaction of any of the 3 nutrition components for either BMI or obesity. <b><i>Discussion:</i></b> The interaction of BMI PRS with calorie intake was investigated in 3 independent Korean cohorts (total <i>n</i> = 35,094) and no interactions were found between PRS and calorie intake for obesity.