cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12546923.v1
title: Untitled ItemAA

description: This a test dataset.
DOI: 10.6084/m9.figshare.12546977.v1
title: Database S2 from Information transfer efficiency differs in wild chimpanzees and bonobos, but not social cognition

description: Data used to run the Model 1b
DOI: 10.6084/m9.figshare.12546902
title: Supplementary Material for: Evaluation of Biomarkers for the Prediction of Venous Thromboembolism in Ambulatory Cancer Patients

description: <b><i>Background:</i></b> Venous thromboembolism (VTE) is a common complication of cancer. This study aimed to evaluate immature platelet fraction (IPF), mean platelet volume (MPV), P-selectin, D-dimer, and thrombin generation (TG) as predictive biomarkers for VTE and further the improvement of existing risk assessment models (RAMs). <b><i>Methods:</i></b> A prospective, observational, exploratory study was conducted on ambulatory cancer patients with indication for systemic chemotherapy. Baseline RAMs included the Khorana-, Vienna Cancer, Thrombosis-, Protecht-, ONKOTEV-, and Catscore. IPF, MPV, P-selectin, D-dimer, and TG were analysed at baseline and 3-month follow-up. <b><i>Results:</i></b> We enrolled 100 patients, of whom 89 completed the follow-up. Frequent tumour types were breast (30%), gastric (14%), gynaecological (14%), and colorectal (14%) cancer. Ten of the 89 patients (11.2%) developed VTE. The highest VTE rate was observed in patients with cholangiocarcinoma (3/5; 60%). Baseline D-dimer levels but not IPF, MPV, or P-selectin were associated with the risk of developing VTE (HR 6.9; <i>p</i> = 0.021). None of the RAMs showed statistical significance in predicting VTE. Peak thrombin and endogenous thrombin potential were lower in patients who developed VTE. Biomarker changes between baseline and follow-up were not associated with VTE risk. <b><i>Conclusions:</i></b> VTE risk was well predicted by baseline D-dimer levels. Adding D-dimer could improve existing RAMs to better identify patients who may benefit from primary VTE prophylaxis. The VTE risk among patients with cholangiocarcinoma should be further evaluated.
DOI: 10.6084/m9.figshare.12546920
title: Supplementary Material for: The Impact of Palliative Care Team Consultation on Quality of Life of Patients with Advanced Cancer in Dutch Hospitals: An Observational Study

description: <b><i>Introduction:</i></b> Experimental studies have shown that palliative care team (PCT) involvement can improve quality of life (QoL) and symptom burden of patients with advanced cancer. It is unclear to what extent this effect is sustained in daily practice of hospital care. <b><i>Objective:</i></b> This observational study aims to investigate the effect of PCT consultation on QoL and symptom burden of hospitalized patients with advanced cancer in daily practice. <b><i>Methods:</i></b> After admission to 1 of 9 participating hospitals, patients with advanced cancer for whom the attending physician answered “no” to the Surprise Question were invited to complete a questionnaire, including the EORTC QLQ-C15-PAL, at 6 points in time, until 3 months after admission. Outcomes were compared between patients who received PCT consultation and patients who did not, taking into account differences in baseline characteristics. <b><i>Results:</i></b> A total of 164 patients consented to participate, of whom 32 received PCT consultation. Of these patients, 108 were able to complete a questionnaire at day 14, of whom 19 after receiving PCT consultation. After adjusting for baseline differences, EORTC QLQ-C15-PAL scores for pain, appetite, and emotional functioning at day 14 were more favorable for patients who received a PCT consultation. <b><i>Conclusion:</i></b> PCT consultation decreased patients’ symptom burden and tends to have a positive effect on QoL of hospitalized patients with advanced cancer, even if the PCT is consulted late in the patient’s disease trajectory.
DOI: 10.6084/m9.figshare.12546920.v1
title: Supplementary Material for: The Impact of Palliative Care Team Consultation on Quality of Life of Patients with Advanced Cancer in Dutch Hospitals: An Observational Study

description: <b><i>Introduction:</i></b> Experimental studies have shown that palliative care team (PCT) involvement can improve quality of life (QoL) and symptom burden of patients with advanced cancer. It is unclear to what extent this effect is sustained in daily practice of hospital care. <b><i>Objective:</i></b> This observational study aims to investigate the effect of PCT consultation on QoL and symptom burden of hospitalized patients with advanced cancer in daily practice. <b><i>Methods:</i></b> After admission to 1 of 9 participating hospitals, patients with advanced cancer for whom the attending physician answered “no” to the Surprise Question were invited to complete a questionnaire, including the EORTC QLQ-C15-PAL, at 6 points in time, until 3 months after admission. Outcomes were compared between patients who received PCT consultation and patients who did not, taking into account differences in baseline characteristics. <b><i>Results:</i></b> A total of 164 patients consented to participate, of whom 32 received PCT consultation. Of these patients, 108 were able to complete a questionnaire at day 14, of whom 19 after receiving PCT consultation. After adjusting for baseline differences, EORTC QLQ-C15-PAL scores for pain, appetite, and emotional functioning at day 14 were more favorable for patients who received a PCT consultation. <b><i>Conclusion:</i></b> PCT consultation decreased patients’ symptom burden and tends to have a positive effect on QoL of hospitalized patients with advanced cancer, even if the PCT is consulted late in the patient’s disease trajectory.
DOI: 10.6084/m9.figshare.12546686
title: The raw output values for FACS analysis (FCS) and the details of experiments and linked files

description: This contains the data obtained during analysis of the outcomes of the research titled "Towards understanding the cell surface phenotype, metabolic properties and immune functions of resident macrophages of the peritoneal cavity and splenic red pulp using high resolution quantitative proteomics"<br><br>The PPT file outlines the details of FACS experiments and associated raw files. The raw files named SM_PM_1 to SM_PM_10 can be opened using FlowJo _V10. which will link the corresponding .fcs files listed in the tables. The corresponding antibodies and fluorochromes used are also listed in the tables .
DOI: 10.6084/m9.figshare.12546581
title: Supplementary material.docx

description: supplementary data
DOI: 10.6084/m9.figshare.12546632
title: Killifish fluctuating temperature

description: set of primary data used for analysis presented in "Fluctuating temperatures extend median lifespan, improves reproduction and reduces growth in turquoise killifish"<b></b>
DOI: 10.6084/m9.figshare.12546563
title: Virus survival in evaporated saliva microdroplets deposited on inanimate surfaces

description: Raw data of Virus survival via plaque assays. This Dataset was used to prepare Fig. 4 in the Paper.<br>
DOI: 10.6084/m9.figshare.12546581.v1
title: Supplementary material.docx

description: supplementary data
DOI: 10.6084/m9.figshare.12546686.v3
title: The raw output values for FACS analysis (FCS) and the details of experiments and linked files

description: This contains the data obtained during analysis of the outcomes of the research titled "Towards understanding the cell surface phenotype, metabolic properties and immune functions of resident macrophages of the peritoneal cavity and splenic red pulp using high resolution quantitative proteomics"<br><br>The PPT file outlines the details of FACS experiments and associated raw files. The raw files named SM_PM_1 to SM_PM_10 can be opened using FlowJo _V10. which will link the corresponding .fcs files listed in the tables. The corresponding antibodies and fluorochromes used are also listed in the tables .
DOI: 10.6084/m9.figshare.12546536
title: Supplementary Material for: A Comprehensive Multidisciplinary Management Plan Is Effective in Reducing the Prevalence of Overweight and Obesity in Childhood and Adolescence

description: <b><i>Background:</i></b> Obesity in childhood and adolescence represents a major health problem of our century. In Greece, 30–35% of children and adolescents are overweight or obese. <b><i>Objective and Hypotheses:</i></b> To investigate the effectiveness of a comprehensive multidisciplinary personalized management plan at reducing the prevalence of overweight and obesity in childhood and adolescence. <b><i>Patients and Methods:</i></b> One thousand (<i>n</i> = 1,000) children and adolescents aged 2–18 years (mean age ± SD: 10.09 ± 2.86 years; 520 females, 480 males) were studied prospectively. Subjects were classified as obese (<i>n</i> = 579, 57.9%), overweight (<i>n</i> = 295, 29.5%) or having a normal body mass index (BMI) (<i>n</i> = 126, 12.6%) according to the International Obesity Task Force cutoff points. All subjects were evaluated by a multidisciplinary team at frequent intervals, received personalized advice on diet and exercise and were studied prospectively for 1 year. Detailed clinical evaluation and laboratory investigations were performed at the beginning and at the end of the study. <b><i>Results:</i></b> At initial evaluation, 57.9% of subjects were obese, 29.5% overweight and 12.6% of normal BMI. Indices of cardiometabolic disease were higher in obese than in overweight and normal-BMI subjects. Following 1 year of multidisciplinary management interventions, the prevalence of obesity decreased by 16.8%, the prevalence of normal BMI increased by 8.2%, and all cardiometabolic indices improved significantly. <b><i>Conclusions:</i></b> A personalized multidisciplinary management plan is effective at reducing the prevalence of obesity in childhood and adolescence.
DOI: 10.6084/m9.figshare.12546560
title: dataset.xls

description: A total of 997 data collected from a geographically well-defined catchment areas which represent the mixed culture and social, economic characteristics of Kerala population in India in 2018.
DOI: 10.6084/m9.figshare.12546455
title: Supporting information for "Simple Topographic Parameter for Along-trench Friction Distribution of Shallow Megathrust Fault"

description: This is the supporting information for "Simple Topographic Parameter for Along-trench Friction Distribution of Shallow Megathrust Fault"<br>
DOI: 10.6084/m9.figshare.12546536.v1
title: Supplementary Material for: A Comprehensive Multidisciplinary Management Plan Is Effective in Reducing the Prevalence of Overweight and Obesity in Childhood and Adolescence

description: <b><i>Background:</i></b> Obesity in childhood and adolescence represents a major health problem of our century. In Greece, 30–35% of children and adolescents are overweight or obese. <b><i>Objective and Hypotheses:</i></b> To investigate the effectiveness of a comprehensive multidisciplinary personalized management plan at reducing the prevalence of overweight and obesity in childhood and adolescence. <b><i>Patients and Methods:</i></b> One thousand (<i>n</i> = 1,000) children and adolescents aged 2–18 years (mean age ± SD: 10.09 ± 2.86 years; 520 females, 480 males) were studied prospectively. Subjects were classified as obese (<i>n</i> = 579, 57.9%), overweight (<i>n</i> = 295, 29.5%) or having a normal body mass index (BMI) (<i>n</i> = 126, 12.6%) according to the International Obesity Task Force cutoff points. All subjects were evaluated by a multidisciplinary team at frequent intervals, received personalized advice on diet and exercise and were studied prospectively for 1 year. Detailed clinical evaluation and laboratory investigations were performed at the beginning and at the end of the study. <b><i>Results:</i></b> At initial evaluation, 57.9% of subjects were obese, 29.5% overweight and 12.6% of normal BMI. Indices of cardiometabolic disease were higher in obese than in overweight and normal-BMI subjects. Following 1 year of multidisciplinary management interventions, the prevalence of obesity decreased by 16.8%, the prevalence of normal BMI increased by 8.2%, and all cardiometabolic indices improved significantly. <b><i>Conclusions:</i></b> A personalized multidisciplinary management plan is effective at reducing the prevalence of obesity in childhood and adolescence.
DOI: 10.6084/m9.figshare.12546632.v1
title: Killifish fluctuating temperature

description: set of primary data used for analysis presented in "Fluctuating temperatures extend median lifespan, improves reproduction and reduces growth in turquoise killifish"<b></b>
DOI: 10.6084/m9.figshare.12546560.v1
title: dataset.xls

description: A total of 997 data collected from a geographically well-defined catchment areas which represent the mixed culture and social, economic characteristics of Kerala population in India in 2018.
DOI: 10.6084/m9.figshare.12546455.v2
title: Supporting information for "Simple Topographic Parameter for Along-trench Friction Distribution of Shallow Megathrust Fault"

description: This is the supporting information for "Simple Topographic Parameter for Along-trench Friction Distribution of Shallow Megathrust Fault"<br>
DOI: 10.6084/m9.figshare.12546455.v1
title: Supporting information for "Simple Topographic Parameter for Along-trench Friction Distribution of Shallow Megathrust Fault"

description: This is the supporting information for "Simple Topographic Parameter for Along-trench Friction Distribution of Shallow Megathrust Fault"<br>
DOI: 10.6084/m9.figshare.12546290
title: Data set.xlsx

description: In this study, we examined the relationship between serum IgG titers to periodontal pathogens and outcome in ischemic stroke patients.
DOI: 10.6084/m9.figshare.12546290.v1
title: Data set.xlsx

description: In this study, we examined the relationship between serum IgG titers to periodontal pathogens and outcome in ischemic stroke patients.
DOI: 10.6084/m9.figshare.12546242
title: Microsatellite data and sampling locations

description: <b>The importance of long-term genetic monitoring of reintroduced populations: inbreeding in the natterjack toad (<i>Epidalea calamita</i>)</b><b><br></b><b> </b>Susanna Phillips<sup>1</sup>, Matthew Geary<sup>1</sup>, Matthew Allmark<sup>2</sup>, Sarah Bennett<sup>2</sup>, Kim Norman<sup>3</sup>, Rachel J. Ball<sup>1</sup>, Catherine M. Peters<sup>1</sup>, Anna P. Muir<sup>1*</sup><sup><br></sup><sup>1</sup>Conservation Biology Research Group, University of Chester, Chester, CH1 4BJ, UK.<sup>2</sup>Cheshire Wildlife Trust, Bickley Hall Farm, Bickley, Malpas, Cheshire, SY14 8EF, UK.<sup>3</sup>Eni UK Ltd, Liverpool Bay, Point of Ayr, Station Road, Talacre, Flintshire, CH8 9RD, UK.<br>The Herpetological Journal 2020<br>
DOI: 10.6084/m9.figshare.12546242.v1
title: Microsatellite data and sampling locations

description: <b>The importance of long-term genetic monitoring of reintroduced populations: inbreeding in the natterjack toad (<i>Epidalea calamita</i>)</b><b><br></b><b> </b>Susanna Phillips<sup>1</sup>, Matthew Geary<sup>1</sup>, Matthew Allmark<sup>2</sup>, Sarah Bennett<sup>2</sup>, Kim Norman<sup>3</sup>, Rachel J. Ball<sup>1</sup>, Catherine M. Peters<sup>1</sup>, Anna P. Muir<sup>1*</sup><sup><br></sup><sup>1</sup>Conservation Biology Research Group, University of Chester, Chester, CH1 4BJ, UK.<sup>2</sup>Cheshire Wildlife Trust, Bickley Hall Farm, Bickley, Malpas, Cheshire, SY14 8EF, UK.<sup>3</sup>Eni UK Ltd, Liverpool Bay, Point of Ayr, Station Road, Talacre, Flintshire, CH8 9RD, UK.<br>The Herpetological Journal 2020<br>
DOI: 10.6084/m9.figshare.12546200
title: Supplementary Material for: A Phase 3, Multicenter, Randomized, Two-Arm, Open-Label Study of Intermittent Oral Dosing of Roxadustat for the Treatment of Anemia in Japanese Erythropoiesis-Stimulating Agent-Naïve Chronic Kidney Disease Patients Not on Dialysis

description: <b><i>Introduction:</i></b> Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor approved for the treatment of anemia in Japan for patients with dialysis-dependent (DD) chronic kidney disease (CKD). <b><i>Objective:</i></b> Multicenter, randomized, open-label, noncomparative, phase 3 study to evaluate roxadustat for anemia of non-dialysis-dependent (NDD) CKD in Japan. <b><i>Methods:</i></b> Erythropoiesis stimulating agent (ESA)-naïve NDD-CKD patients were randomized to roxadustat (initial dose, 50 or 70 mg 3 times weekly), titrated to maintain hemoglobin (Hb) within 10.0–12.0 g/dL, for ≤24 weeks. Patients with either transferrin saturation of ≥5% or serum ferritin of ≥30 ng/mL during the screening period were eligible. Endpoints included response rate (proportion of patients achieving Hb ≥10.0 or ≥10.5 g/dL and Hb increase ≥1.0 g/dL from baseline) at end of treatment; average Hb (weeks 18–24); change of average Hb from baseline to weeks 18–24; maintenance rate (proportion of patients achieving Hb 10.0–12.0 g/dL at weeks 18–24); rate of rise (RoR) of Hb from weeks 0–4, discontinuation, or dose adjustment. Adverse events were monitored throughout the study. <b><i>Results:</i></b> Of 135 patients who provided informed consent, 100 were randomized and 99 received roxadustat (50 mg, <i>n</i> = 49; 70 mg, <i>n</i> = 50). The mean (SD) dose of roxadustat per intake at week 22 was 36.3 (22.7) mg in the roxadustat 50 mg group and 36.8 (16.0) mg in the roxadustat 70 mg group. Prior medications included oral iron therapy (20.2%) and intravenous iron therapy (1.0%). Overall response rate (95% CI) was 97.0% (91.4, 99.4; Hb ≥10.0 g/dL) and 94.9% (88.6, 98.3; Hb ≥10.5 g/dL). Mean (SD) Hb (weeks 18–24) was 11.17 (0.62) g/dL. Mean (SD) change of Hb from baseline (weeks 18–24) was 1.34 (0.86) g/dL. Maintenance rate (95% CI) was 88.8% (80.3, 94.5) among patients with ≥1 Hb measurement during weeks 18–24. Mean (SD) RoR of Hb was 0.291 (0.197) g/dL/week (50 mg) and 0.373 (0.235) g/dL/week (70 mg). Nasopharyngitis and hypertension were the most common adverse events. <b><i>Conclusion:</i></b> Roxadustat increased and maintained Hb in ESA-naïve, partially iron-depleted NDD-CKD patients with anemia.
DOI: 10.6084/m9.figshare.12546341.v1
title: Pavo_18Plus.pdf

description: Pienso para caballos 18Plus de la marca PAVO
DOI: 10.6084/m9.figshare.12546200.v1
title: Supplementary Material for: A Phase 3, Multicenter, Randomized, Two-Arm, Open-Label Study of Intermittent Oral Dosing of Roxadustat for the Treatment of Anemia in Japanese Erythropoiesis-Stimulating Agent-Naïve Chronic Kidney Disease Patients Not on Dialysis

description: <b><i>Introduction:</i></b> Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor approved for the treatment of anemia in Japan for patients with dialysis-dependent (DD) chronic kidney disease (CKD). <b><i>Objective:</i></b> Multicenter, randomized, open-label, noncomparative, phase 3 study to evaluate roxadustat for anemia of non-dialysis-dependent (NDD) CKD in Japan. <b><i>Methods:</i></b> Erythropoiesis stimulating agent (ESA)-naïve NDD-CKD patients were randomized to roxadustat (initial dose, 50 or 70 mg 3 times weekly), titrated to maintain hemoglobin (Hb) within 10.0–12.0 g/dL, for ≤24 weeks. Patients with either transferrin saturation of ≥5% or serum ferritin of ≥30 ng/mL during the screening period were eligible. Endpoints included response rate (proportion of patients achieving Hb ≥10.0 or ≥10.5 g/dL and Hb increase ≥1.0 g/dL from baseline) at end of treatment; average Hb (weeks 18–24); change of average Hb from baseline to weeks 18–24; maintenance rate (proportion of patients achieving Hb 10.0–12.0 g/dL at weeks 18–24); rate of rise (RoR) of Hb from weeks 0–4, discontinuation, or dose adjustment. Adverse events were monitored throughout the study. <b><i>Results:</i></b> Of 135 patients who provided informed consent, 100 were randomized and 99 received roxadustat (50 mg, <i>n</i> = 49; 70 mg, <i>n</i> = 50). The mean (SD) dose of roxadustat per intake at week 22 was 36.3 (22.7) mg in the roxadustat 50 mg group and 36.8 (16.0) mg in the roxadustat 70 mg group. Prior medications included oral iron therapy (20.2%) and intravenous iron therapy (1.0%). Overall response rate (95% CI) was 97.0% (91.4, 99.4; Hb ≥10.0 g/dL) and 94.9% (88.6, 98.3; Hb ≥10.5 g/dL). Mean (SD) Hb (weeks 18–24) was 11.17 (0.62) g/dL. Mean (SD) change of Hb from baseline (weeks 18–24) was 1.34 (0.86) g/dL. Maintenance rate (95% CI) was 88.8% (80.3, 94.5) among patients with ≥1 Hb measurement during weeks 18–24. Mean (SD) RoR of Hb was 0.291 (0.197) g/dL/week (50 mg) and 0.373 (0.235) g/dL/week (70 mg). Nasopharyngitis and hypertension were the most common adverse events. <b><i>Conclusion:</i></b> Roxadustat increased and maintained Hb in ESA-naïve, partially iron-depleted NDD-CKD patients with anemia.
DOI: 10.6084/m9.figshare.12546341
title: Piensos Essential para caballos marca PAVO en Agroanimal

description: Fichas técnicas de piensos para caballos Marca PAVO en su categoría Essential distribuidos por Agroanimal
DOI: 10.6084/m9.figshare.12546182
title: Supplementary Material for: Is Fluorescence Technology a Promising Tool for Detecting Infected Dentin in Deep Carious Lesions?

description: The purpose of this study was to determine if the degree of fluorescence detected by fluorescence-aided caries excavation (FACE) correlates with dentin bacterial microbiome diversity, as assessed by 16S rRNA gene amplicon sequencing, and with traditional tactile dentin caries assessment. Unidentified human teeth were obtained from a dental facility. The included teeth had a carious lesion two-thirds into the dentin, verified by radiography, and were red-fluorescing (RF) using FACE technology (SIROInspect; Sirona, Bensheim, Germany). Two independent examiners performed visual/tactile assessment of the lesions. RF sites were sampled with a sterile spoon excavator and dentin characteristics were evaluated. Once RF dentin was removed, a second sample of pink-fluorescing (PF) dentin was obtained. After excavation with a sterile round bur to nonfluorescing (NF) dentin, a third sample was collected with a slow-speed round bur. The samples were processed at the UNC (University of North Carolina at Chapel Hill) Microbiome Core Facility. Out of 134 extracted teeth collected, 21 fit the inclusion criteria, yielding 61 dentin samples. RF samples had the highest number of observed operational taxonomic units (<i>n</i> = 154), followed by PF (<i>n</i> = 109) and NF (<i>n</i> = 100). RF carious dentin was primarily “soft,” and NF dentin was assessed as “hard” 100% of the time by both examiners (rank correlation χ<sup>2</sup>: <i>p</i> &lt; 0.001). However, approximately one-third of the tactile assessments of hard dentin still displayed some fluorescence, either pink or red. We concluded that the sampled fluorescing (RF and PF) and NF carious dentin layers displayed diverse bacterial taxa, and tactile assessments of soft, leathery, and hard corresponded with RF, PF, and NF.