cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.17905113
title: The Astrophysics LISA "Disc-IMRI" Code Comparison Project: Simulation Data
title: High-mass-ratio binaries in AGN-like discs

description: This repository contains the simulation data that was generated for the LISA Astrophysics Working Group code comparison project on intermediate-mass ratio binaries in AGN-like accretion disks. The project utilized simulations of binaries embedded in an isothermal, viscous accretion disk using 8 codes: ATHENA++, DISCO (2 versions), FARGO3D, GASOLINE, GIZMO, PHANTOM, and RAMSES. We provide timeseries files (labeled by <author>_<code>_<resolution>_<massratio>_<aspectratio>.dat) that contain the torque components on the binary versus time, and snapshot files (labeled by <author>_<code>_<resolution>_<massratio>_<aspectratio>_<orbits>.dat) that contain the fluid x and y positions, surface densities, and Cartesian velocities.
DOI: 10.5281/zenodo.17372153
title: The Astrophysics LISA "Disc-IMRI" Code Comparison Project: Simulation Data
title: High-mass-ratio binaries in AGN-like discs

description: This repository contains the simulation data that was generated for the LISA Astrophysics Working Group code comparison project on intermediate-mass ratio binaries in AGN-like accretion disks. The project utilized simulations of binaries embedded in an isothermal, viscous accretion disk using 8 codes: ATHENA++, DISCO (2 versions), FARGO3D, GASOLINE, GIZMO, PHANTOM, and RAMSES. We provide timeseries files (labeled by <author>_<code>_<resolution>_<massratio>_<aspectratio>.dat) that contain the torque components on the binary versus time, and snapshot files (labeled by <author>_<code>_<resolution>_<massratio>_<aspectratio>_<orbits>.dat) that contain the fluid x and y positions, surface densities, and Cartesian velocities.
DOI: 10.17026/ar/anxsbp
title: PAN-00179895 - bronze spearhead/lancehead

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00179895&lt;/p&gt;
description: Modified: 2025-09-30T14:21:40+02:00
DOI: 10.5281/zenodo.17905472
title: Redox-driven diagenetic impacts on sedimentary and magnetic records during late Pleistocene oceanographic evolution on the Ross Sea continental margin

description: This archive file contains all data produced in the paper "Redox-driven diagenetic impacts on sedimentary and magnetic records during late Pleistocene oceanographic evolution on the Ross Sea continental margin" submitted to Palaeogeography, Palaeoclimatology, Palaeoecology.

 

- Supplementary Data Set 01. Magnetic, sedimentary, and geochemical data for core RS15-GC44
DOI: 10.5281/zenodo.17905471
title: Redox-driven diagenetic impacts on sedimentary and magnetic records during late Pleistocene oceanographic evolution on the Ross Sea continental margin

description: This archive file contains all data produced in the paper "Redox-driven diagenetic impacts on sedimentary and magnetic records during late Pleistocene oceanographic evolution on the Ross Sea continental margin" submitted to Palaeogeography, Palaeoclimatology, Palaeoecology.

 

- Supplementary Data Set 01. Magnetic, sedimentary, and geochemical data for core RS15-GC44
DOI: 10.6084/m9.figshare.29467593.v1
title: Extract of <i>Scytonema bilaspurense</i> NK13 strongly exhibits anticancer activities on cervical cancer HeLa cells

description: Cyanobacteria are new emerging sources of anticancer compounds with many lead structures for drug development. This study aimed to elucidate the anticancer activity of the crude extract of <i>Scytonema bilaspurense</i> NK13 on cervical cancer HeLa cells based on its ability to induce apoptotic inducements, arrest cell cycles and inhibit cell invasion. As a result, a number of cells treated with the NK13 extract (NK13E) entering apoptotic phases were 5.0-fold higher than that of negative control cells. Accordingly, the transcript levels of <i>BAX</i>, <i>CASPASE-8</i>, and <i>CASPASE-3</i> in the NK13E-treated cells were up-regulated with 23.7-, 3.6- and 1.3-fold, respectively, higher than those in the negative control cells. Moreover, treatment with NK13E caused cell cycle arrest at the S phase in a p53-independent manner. Particularly, percentages of NK13E-treated cells in sub-G1, S, G2/M were 22.2%, 24.6% and 13.8%, while percentages of DMSO-treated-control cells in sub-G1, S, G2/M were 3.3%, 15.3% and 19.7%, respectively. Consistent with cell cycle arrest results, the expression levels of <i>CDKN1A</i> and <i>CDNK2A</i> in NK13E-treated cells were promoted to 26.6-folds and 5.6-folds higher than those of negative control cells, respectively. In addition, NK13E could also significantly inhibit invasion ability of the cells <i>in vitro</i>. This result was proven by up-regulating <i>FAK</i>/<i>PI3K</i>/<i>AKT</i>, along with down-regulating <i>N-cadherin</i>, which plays a crucial role in regulating the invasion activity of cancer cells. In conclusion, we suggest that the <i>Scytonema bilaspurense</i> NK13 strain is a potential source of precious compounds for developing new therapies for cervical cancer treatment.
DOI: 10.6084/m9.figshare.30849991
title: Reviewing laboratory culturing of laminarian kelp: <i>Laminaria hyperborea</i>, <i>L. digitata</i>, and <i>Saccharina latissima</i> and their use in ecotoxicology

description: Despite underpinning entire polar and temperate coastal ecosystems, kelp is rarely examined in standard ecotoxicology test batteries, and no universally accepted testing guidelines exist despite the growing regulatory interest in macroalgal tests. Declines in kelp populations, linked increasingly to pollution and other anthropogenic stressors, reinforce an urgent need to quantify contaminant effects on kelp health and survival. Reliable and consistent kelp cultivation protocols are therefore essential for generating ecotoxicological data that both addresses critical gaps in environmental risk assessment and provides alternatives to vertebrate testing in toxicology. The microscopic kelp life stages present a particular opportunity for reproducible assays at recognized bottlenecks in the life cycle, where kelp is often most sensitive to environmental stressors. This review consolidates laboratory cultivation techniques for three key species: <i>Laminaria hyperborea</i>, <i>L. digitata</i>, and <i>Saccharina latissima</i>, drawing on published literature and practitioner interviews. Protocols are outlined for spores, gametophytes, juvenile sporophytes, and mature sporophytes, with an emphasis on managing life stage transitions. Key parameters include temperature (5–15°C), nutrient enrichment (F2P), and precise control of light intensity, wavelength, and photoperiod. Strategies to address challenges such as contamination, genetic drift, and long-term culture maintenance are identified, alongside a discussion of emerging efforts to standardize kelp bioassays. The synthesis supports a broader and more robust use of kelp-based assays, which will strengthen our capacity to assess and understand pollution risks to kelp forests, and advance conservation and sustainable management of coastal ecosystems.
DOI: 10.6084/m9.figshare.30849991.v1
title: Reviewing laboratory culturing of laminarian kelp: <i>Laminaria hyperborea</i>, <i>L. digitata</i>, and <i>Saccharina latissima</i> and their use in ecotoxicology

description: Despite underpinning entire polar and temperate coastal ecosystems, kelp is rarely examined in standard ecotoxicology test batteries, and no universally accepted testing guidelines exist despite the growing regulatory interest in macroalgal tests. Declines in kelp populations, linked increasingly to pollution and other anthropogenic stressors, reinforce an urgent need to quantify contaminant effects on kelp health and survival. Reliable and consistent kelp cultivation protocols are therefore essential for generating ecotoxicological data that both addresses critical gaps in environmental risk assessment and provides alternatives to vertebrate testing in toxicology. The microscopic kelp life stages present a particular opportunity for reproducible assays at recognized bottlenecks in the life cycle, where kelp is often most sensitive to environmental stressors. This review consolidates laboratory cultivation techniques for three key species: <i>Laminaria hyperborea</i>, <i>L. digitata</i>, and <i>Saccharina latissima</i>, drawing on published literature and practitioner interviews. Protocols are outlined for spores, gametophytes, juvenile sporophytes, and mature sporophytes, with an emphasis on managing life stage transitions. Key parameters include temperature (5–15°C), nutrient enrichment (F2P), and precise control of light intensity, wavelength, and photoperiod. Strategies to address challenges such as contamination, genetic drift, and long-term culture maintenance are identified, alongside a discussion of emerging efforts to standardize kelp bioassays. The synthesis supports a broader and more robust use of kelp-based assays, which will strengthen our capacity to assess and understand pollution risks to kelp forests, and advance conservation and sustainable management of coastal ecosystems.
DOI: 10.6084/m9.figshare.28000403
title: Algal biomusic generation

description: Technologies which can generate music with limited human intervention are a longstanding area of investigation for musicians and musicologists, with particular interest in how these technologies can be harnessed for ecocentric forms of musical expression. To date, most of these efforts have focused on the use of computational algorithms to compose music. Biomusic – music created using biological data – provides an alternative paradigm for the creation of non-human music which can be truly ecocentric. Photosynthetic organisms in particular offer the ability to create music which responds to changes in their environment, such as changes in light conditions and temperature. Herein, we propose how the ubiquitous bioelectrical activities of algae (which are correlated with their photosynthetic activity) can be utilized for biomusic generation. In addition to describing the scientific principles underpinning these algal biomusic systems, we also provide tutorial descriptions of the bioelectrochemical devices and signal processing pipelines which can be used to engineer them. In addition, we provide an overview of the many musical applications that can be accessed with this technology, highlighting a few pioneering examples of algal biomusic generation.
DOI: 10.6084/m9.figshare.28000403.v1
title: Algal biomusic generation

description: Technologies which can generate music with limited human intervention are a longstanding area of investigation for musicians and musicologists, with particular interest in how these technologies can be harnessed for ecocentric forms of musical expression. To date, most of these efforts have focused on the use of computational algorithms to compose music. Biomusic – music created using biological data – provides an alternative paradigm for the creation of non-human music which can be truly ecocentric. Photosynthetic organisms in particular offer the ability to create music which responds to changes in their environment, such as changes in light conditions and temperature. Herein, we propose how the ubiquitous bioelectrical activities of algae (which are correlated with their photosynthetic activity) can be utilized for biomusic generation. In addition to describing the scientific principles underpinning these algal biomusic systems, we also provide tutorial descriptions of the bioelectrochemical devices and signal processing pipelines which can be used to engineer them. In addition, we provide an overview of the many musical applications that can be accessed with this technology, highlighting a few pioneering examples of algal biomusic generation.
DOI: 10.6084/m9.figshare.29467593
title: Extract of <i>Scytonema bilaspurense</i> NK13 strongly exhibits anticancer activities on cervical cancer HeLa cells

description: Cyanobacteria are new emerging sources of anticancer compounds with many lead structures for drug development. This study aimed to elucidate the anticancer activity of the crude extract of <i>Scytonema bilaspurense</i> NK13 on cervical cancer HeLa cells based on its ability to induce apoptotic inducements, arrest cell cycles and inhibit cell invasion. As a result, a number of cells treated with the NK13 extract (NK13E) entering apoptotic phases were 5.0-fold higher than that of negative control cells. Accordingly, the transcript levels of <i>BAX</i>, <i>CASPASE-8</i>, and <i>CASPASE-3</i> in the NK13E-treated cells were up-regulated with 23.7-, 3.6- and 1.3-fold, respectively, higher than those in the negative control cells. Moreover, treatment with NK13E caused cell cycle arrest at the S phase in a p53-independent manner. Particularly, percentages of NK13E-treated cells in sub-G1, S, G2/M were 22.2%, 24.6% and 13.8%, while percentages of DMSO-treated-control cells in sub-G1, S, G2/M were 3.3%, 15.3% and 19.7%, respectively. Consistent with cell cycle arrest results, the expression levels of <i>CDKN1A</i> and <i>CDNK2A</i> in NK13E-treated cells were promoted to 26.6-folds and 5.6-folds higher than those of negative control cells, respectively. In addition, NK13E could also significantly inhibit invasion ability of the cells <i>in vitro</i>. This result was proven by up-regulating <i>FAK</i>/<i>PI3K</i>/<i>AKT</i>, along with down-regulating <i>N-cadherin</i>, which plays a crucial role in regulating the invasion activity of cancer cells. In conclusion, we suggest that the <i>Scytonema bilaspurense</i> NK13 strain is a potential source of precious compounds for developing new therapies for cervical cancer treatment.
DOI: 10.6084/m9.figshare.30580113
title: Global seaweed stock and Marine Protected Area assessments provide potential opportunities to protect wild seaweeds

description: Wild seaweeds and associated habitats are the basis of the world’s seaweed industry, yet they lack adequate global conservation protection. A review of the industry’s global distribution, production and species based on available datasets and literature searches revealed that seaweed wild harvesting and aquaculture were reported in 82 countries on five continents. However, analysis of key datasets (FAO and Phyconomy) revealed reporting inconsistencies within the industry. Widespread uncertainty as to which species are used and the quantities produced by the industry has implications for wild stock sustainability, biosecurity, product provenance and safety. This points to the need for greater standardization and wild stock protection by the industry. Analysis of the industry’s global distribution in relationship to Marine Protected Areas revealed c. 50% of aquaculture and wild harvesting sites were close to conservation areas. This presents farmers and harvesters with a potential opportunity to strategically develop the MPA concept to protect wild stocks and secure the long-term future of this industry. There is a lack of certainty of the species identity used in the seaweed industry.There is a need for greater standardization in the seaweed industry and protection of wild stocks.The discovery that c. 50% of Marine Protected Areas globally were close to seaweed farms and wild harvesting sites raises the possibility that MPAs could be developed to afford the industry potential protection. There is a lack of certainty of the species identity used in the seaweed industry. There is a need for greater standardization in the seaweed industry and protection of wild stocks. The discovery that c. 50% of Marine Protected Areas globally were close to seaweed farms and wild harvesting sites raises the possibility that MPAs could be developed to afford the industry potential protection.
DOI: 10.6084/m9.figshare.30580113.v1
title: Global seaweed stock and Marine Protected Area assessments provide potential opportunities to protect wild seaweeds

description: Wild seaweeds and associated habitats are the basis of the world’s seaweed industry, yet they lack adequate global conservation protection. A review of the industry’s global distribution, production and species based on available datasets and literature searches revealed that seaweed wild harvesting and aquaculture were reported in 82 countries on five continents. However, analysis of key datasets (FAO and Phyconomy) revealed reporting inconsistencies within the industry. Widespread uncertainty as to which species are used and the quantities produced by the industry has implications for wild stock sustainability, biosecurity, product provenance and safety. This points to the need for greater standardization and wild stock protection by the industry. Analysis of the industry’s global distribution in relationship to Marine Protected Areas revealed c. 50% of aquaculture and wild harvesting sites were close to conservation areas. This presents farmers and harvesters with a potential opportunity to strategically develop the MPA concept to protect wild stocks and secure the long-term future of this industry. There is a lack of certainty of the species identity used in the seaweed industry.There is a need for greater standardization in the seaweed industry and protection of wild stocks.The discovery that c. 50% of Marine Protected Areas globally were close to seaweed farms and wild harvesting sites raises the possibility that MPAs could be developed to afford the industry potential protection. There is a lack of certainty of the species identity used in the seaweed industry. There is a need for greater standardization in the seaweed industry and protection of wild stocks. The discovery that c. 50% of Marine Protected Areas globally were close to seaweed farms and wild harvesting sites raises the possibility that MPAs could be developed to afford the industry potential protection.
DOI: 10.6084/m9.figshare.30489613
title: <i>In silico</i> discovery of skin depigmenting agents from <i>Chlorella vulgaris</i>: a network pharmacology and molecular simulation approach

description: Hyperpigmentation is a common skin condition resulting from uncontrolled melanin production or accumulation. Commercial skin-whitening products have been reported to cause undesirable skin effects, limiting safe treatment options. Microalgae are increasingly explored as sustainable sources for cosmetic applications due to their diverse bioactive properties and versatility. <i>Chlorella vulgaris</i>, a green microalga, is regarded as a promising source of beneficial compounds, particularly in cosmeceuticals. In this study, pigmentation-related targets were identified from public databases, and network pharmacology techniques were employed, including protein–protein interaction (PPI) network construction using STRING and visualization in Cytoscape. Enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The interactions between hub targets and <i>C. vulgaris</i> compounds retrieved from PubChem were investigated via molecular docking and molecular dynamics simulations. Hub genes <i>TYRP1</i>, <i>TYR</i>, <i>TP53</i>, <i>SLC45A2</i>, <i>CTNNB1</i>, and <i>MC1R</i> were identified as significant regulators of melanocyte differentiation and melanogenesis-associated pathways. Molecular docking highlighted four hit compounds namely 7,22-ergostadienol acetate (CID: 14056082), dehydroergosterol acetate (CID: 69827569), ergosterol acetate (CID: 6436903), and [(3S,10S,13 R,14 R,17 R)-17-[(E,2 R,5 R)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl 2,3,4,12,14,15,16,17-octahydro-1 H-cyclopenta[a]phenanthren-3-yl] acetate (PubChem CID: 162856537), which showed favourable binding affinities with the core gene targets. Molecular dynamics revealed that these compounds could bind stably to <i>SLC45A2</i>, <i>CTNNB1</i>, and <i>MC1R</i>, suggesting potential depigmenting effects of <i>C. vulgaris</i>. While these findings provide a theoretical framework for microalgae-derived depigmentation agents, the study is based solely on <i>in silico</i> predictions and relies on currently available compound–target databases, which may not encompass the full chemical diversity of <i>C. vulgaris</i>. Therefore, further validation through phytochemical characterization, <i>in vitro</i> assays, and <i>in vivo</i> studies is essential to confirm the therapeutic potential of these compounds for pigmentation-related skin disorders.
DOI: 10.6084/m9.figshare.30489613.v1
title: <i>In silico</i> discovery of skin depigmenting agents from <i>Chlorella vulgaris</i>: a network pharmacology and molecular simulation approach

description: Hyperpigmentation is a common skin condition resulting from uncontrolled melanin production or accumulation. Commercial skin-whitening products have been reported to cause undesirable skin effects, limiting safe treatment options. Microalgae are increasingly explored as sustainable sources for cosmetic applications due to their diverse bioactive properties and versatility. <i>Chlorella vulgaris</i>, a green microalga, is regarded as a promising source of beneficial compounds, particularly in cosmeceuticals. In this study, pigmentation-related targets were identified from public databases, and network pharmacology techniques were employed, including protein–protein interaction (PPI) network construction using STRING and visualization in Cytoscape. Enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The interactions between hub targets and <i>C. vulgaris</i> compounds retrieved from PubChem were investigated via molecular docking and molecular dynamics simulations. Hub genes <i>TYRP1</i>, <i>TYR</i>, <i>TP53</i>, <i>SLC45A2</i>, <i>CTNNB1</i>, and <i>MC1R</i> were identified as significant regulators of melanocyte differentiation and melanogenesis-associated pathways. Molecular docking highlighted four hit compounds namely 7,22-ergostadienol acetate (CID: 14056082), dehydroergosterol acetate (CID: 69827569), ergosterol acetate (CID: 6436903), and [(3S,10S,13 R,14 R,17 R)-17-[(E,2 R,5 R)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl 2,3,4,12,14,15,16,17-octahydro-1 H-cyclopenta[a]phenanthren-3-yl] acetate (PubChem CID: 162856537), which showed favourable binding affinities with the core gene targets. Molecular dynamics revealed that these compounds could bind stably to <i>SLC45A2</i>, <i>CTNNB1</i>, and <i>MC1R</i>, suggesting potential depigmenting effects of <i>C. vulgaris</i>. While these findings provide a theoretical framework for microalgae-derived depigmentation agents, the study is based solely on <i>in silico</i> predictions and relies on currently available compound–target databases, which may not encompass the full chemical diversity of <i>C. vulgaris</i>. Therefore, further validation through phytochemical characterization, <i>in vitro</i> assays, and <i>in vivo</i> studies is essential to confirm the therapeutic potential of these compounds for pigmentation-related skin disorders.
DOI: 10.17026/ar/wrvgxl
title: PAN-00051795 - grindstone/whetstone

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00051795&lt;/p&gt;
description: Modified: 2025-07-10T14:04:05+02:00