cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4312310.v1
title: Supplementary Material for: Effect of Tannic Acid on the Protective Properties of the in situ Formed Pellicle

description: <b><i>Objectives:</i></b> In the present in situ/ex vivo study the impact of tannic acid on the erosion-protective properties of the enamel pellicle was tested. Additionally, the antiadherent and antibacterial effects of tannic acid were evaluated. <b><i>Methods:</i></b> The pellicle was formed in situ on bovine enamel samples fixed on individual splints worn by 6 subjects. Following 1 min of pellicle formation the volunteers rinsed for 10 min with tannic acid. After further oral exposure for 19 min, 109 min, and 8 h overnight, respectively, slabs were incubated in HCl ex vivo (pH 2.0, 2.3, 3.0) over 120 s. Subsequently, kinetics of calcium and phosphate release were measured photometrically. Samples after a 1-min fluoride mouth rinse as well as enamel samples with and without a 30-min in situ pellicle served as controls. Antiadherent effects were evaluated after a 1-min rinse with tannic acid and oral exposure of the slabs overnight. DAPI (4′,6-diamidino-2-phenylindole) combined with concanavalin A staining and live/dead staining was used for fluorescence microscopic visualization and quantification of adherent bacteria and glucans. Modification of the pellicle's ultrastructure by tannic acid was evaluated by transmission electron microscopy (TEM). <b><i>Results:</i></b> Tannic acid significantly improved the erosion-protective properties of the pellicle in a pH-dependent manner. Bacterial adherence and glucan formation on enamel were significantly reduced after rinses with tannic acid as investigated by fluorescence microscopy. TEM imaging indicated that rinsing with tannic acid yielded a sustainable modification of the pellicle; it was distinctly more electron dense. <b><i>Conclusion:</i></b> Tannic acid offers an effective and sustainable approach for the prevention of caries and erosion.
DOI: 10.6084/m9.figshare.9751664.v1
title: Normal Cancer Cell Nucleus

description: Normal Cancer Cell Nucleus
DOI: 10.6084/m9.figshare.21579528.v1
title: elai.845.txt.gz

description: the elai results of the 845 maize.
DOI: 10.6084/m9.figshare.28235360.v1
title: The visual representation of the interaction between amino acids and the compounds identified from Delites™ against specific receptor proteins

description: These data for the visual representation of the interaction between amino acids and the compounds identified from Delites™ against specific receptor proteins
DOI: 10.6084/m9.figshare.28497422.v1
title: Supplementary Material for: Efficacy and Safety of IL-17 and JAK Inhibitors in Ankylosing Spondylitis: A Systematic Review and Network Meta-Analysis

description: Objective: The aim of this study was to compare the clinical efficacy and safety of interleukin-17 inhibitors and Janus kinase inhibitors in the treatment of ankylosing spondylitis based on a network meta-analysis.
Methods: According to the search strategy, systematic retrievals were conducted in PubMed, Embase, Web of Science, the Cochrane Register of Clinical Trials, Scopus, and website ClinicalTrials.gov, from the establishment to December 8, 2023. Randomized controlled trials (RCTs) of interleukin-17 inhibitors and Janus kinase inhibitors for the treatment of ankylosing spondylitis were selected according to the inclusion and exclusion criteria. The included studies were evaluated for quality using the Cochrane Risk of Bias Assessment Tool, and data were statistically analyzed using Software Stata 16.0, to compare the effectiveness and safety differences in all interventions.
Results: A total of 18 RCTs involving 3968 subjects were included in this study. The interventions were ranked from best to worst in terms of ASAS20: netakimab 120 mg &gt; filgotinib 200 mg &gt; tofacitinib 5 mg&gt; brodalumab 210 mg &gt;upadacitinib 15 mg &gt;bimekizumab 160 mg &gt; secukinumab 300 mg&gt; ixekizumab 80 mg Q4W &gt; secukinumab 150 mg &gt; secukinumab 150 mg no LD&gt; placebo, netakimab 120 mg outperformed all other interventions and the difference was statistically significant. The interventions were ranked from best to worst in terms of ASAS40: netakimab 120 mg &gt; tofacitinib 5 mg &gt; secukinumab 150 mg &gt; secukinumab 300 mg &gt; upadacitinib 15 mg &gt; bimekizumab 160 mg&gt; ixekizumab 80 mg Q4W &gt; filgotinib 200 mg &gt; brodalumab 210 mg &gt; secukinumab 150 mg no LD &gt; placebo, netakimab 120 mg outperformed all other interventions and was statistically significant (except the intervention of filgotinib 200 mg). In terms of AEs and SAEs, there was no statistical significance among all interventions.
Conclusions: The results of the network meta-analysis showed that netakimab 120mg ranked relatively high in outcome of ASAS20 and ASAS40. All treatments with IL-17 and JAK inhibitors were generally safe and well tolerated. However, the two included netakimab clinical studies may have limitations. Therefore, the therapeutic agents should be carefully selected in clinical treatment. Moreover, the efficacy and safety of netakimab remain to be further analyzed in studies with larger sample sizes and longer follow-up times.
DOI: 10.6084/m9.figshare.25673634.v1
title: Supplementary Material for: A Rapid Development of Post-Colonoscopy Appendicitis Within Twelve Hours: A Case Report

description: Introduction 
Colon cancer has seen a steady decline in incidence due to increased colonoscopy use. We can assume that this increased use, results in a higher incidence of post-colonoscopy complications such postpolypectomy syndrome, perforation and post-colonoscopy appendicitis (PCA). In this report we present a case of post-colonoscopy appendicitis presenting to the emergency department within 12 hours of a screening colonoscopy. 
Case Presentation
Our patient, a 77-year-old male, underwent an uncomplicated screening colonoscopy and was discharged home after briefly being monitored without any complaints. Later that day, the patient presented to the emergency department complaining of acute generalized abdominal pain. On presentation, the patient was found to be hypertensive and febrile with a distended abdomen with right lower quadrant tenderness on examination. Laboratory investigations noted an elevated white blood cell count with no evidence of acute appendicitis or focal inflammatory changes on contrast-enhanced abdominal and pelvic computer tomography. The patient was subsequently admitted and, developed worsening right lower quadrant abdominal pain and distention overnight. Due to this worsening clinical condition, the decision was made to proceed with a diagnostic laparoscopy. After frank pus was found laparoscopically around the cecum and appendix, it was then converted to an exploratory laparotomy. Subsequently, a perforated gangrenous appendix was found with an erythematous and indurated cecum. 
Conclusion
Major complications of colonoscopy can include perforation and/or post-colonoscopy bleeding which have been shown to have a respective incidence of 0.21% and 0.1%. With the anticipated rise in the number of colonoscopies, much rarer complication such as PCA with an incidence of less than 0.05% will be seen more frequently. Due to its nonspecific presentation, it is necessary for providers to consider PCA as an important differential for all patients presenting with abdominal pain after a colonoscopy.
DOI: 10.6084/m9.figshare.28877078.v1
title: Demo

description: Demo description.
DOI: 10.6084/m9.figshare.9944954.v1
title: Marginal Climate and Air Quality Costs of Aviation Emissions - Supplementary Dataset

description: <b>Supplementary Dataset for "Marginal Climate and Air Quality Costs of Aviation Emissions" - Environmental Research Letters (ERL-106869)</b><br>This dataset defines the uncertainty bounds for Tables SI.13-SI.18 in the paper, by including the full Monte Carlo simulation output data. <br>A CSV file is provided for each column in Table SI.13 to Table SI.18 in the paper. The CSV files include the ordered members of the Monte Carlo simulation, for instance the first row of each CSV file corresponds to the same Monte Carlo member. <br>For net costs including air quality costs, central estimates should be calculated using the central estimates from Table SI.13 to Table SI.18 in the paper. This is because, for air quality, the central values are not derived using Monte Carlo simulation, but rather by selecting a central VSL value as described in Section SI.1.3.1 in the paper. <br>This Monte Carlo dataset should be used to determine the uncertainty bounds for net costs due to changes in emissions of multiple species. <br>
DOI: 10.6084/m9.figshare.16645240.v1
title: Supplementary Material for: Estimation of Baseline Serum Creatinine with Machine Learning

description: <b><i>Introduction:</i></b> Comparing current to baseline serum creatinine is important in detecting acute kidney injury. In this study, we report a regression-based machine learning model to predict baseline serum creatinine. <b><i>Methods:</i></b> We developed and internally validated a gradient boosting model on patients admitted in Mayo Clinic intensive care units from 2005 to 2017 to predict baseline creatinine. The model was externally validated on the Medical Information Mart for Intensive Care III (MIMIC III) cohort in all ICU admissions from 2001 to 2012. The predicted baseline creatinine from the model was compared with measured serum creatinine levels. We compared the performance of our model with that of the backcalculated estimated serum creatinine from the Modification of Diet in Renal Disease (MDRD) equation. <b><i>Results:</i></b> Following ascertainment of eligibility criteria, 44,370 patients from the Mayo Clinic and 6,112 individuals from the MIMIC III cohort were enrolled. Our model used 6 features from the Mayo Clinic and MIMIC III datasets, including the presence of chronic kidney disease, weight, height, and age. Our model had significantly lower error than the MDRD backcalculation (mean absolute error [MAE] of 0.248 vs. 0.374 in the Mayo Clinic test data; MAE of 0.387 vs. 0.465 in the MIMIC III cohort) and higher correlation (intraclass correlation coefficient [ICC] of 0.559 vs. 0.050 in the Mayo Clinic test data; ICC of 0.357 vs. 0.030 in the MIMIC III cohort). <b><i>Discussion/Conclusion:</i></b> Using machine learning models, baseline serum creatinine could be estimated with higher accuracy than the backcalculated estimated serum creatinine level.
DOI: 10.6084/m9.figshare.22331314.v2
title: ctDNA dataset in pT1a clear cell renal cell carcinoma_v1.0

description: This dataset provides details of the data supporting the claims of the related manuscript: “Exploring the characteristics of circulating tumor DNA in pT1a clear cell renal cell carcinoma: a pilot study”.
DOI: 10.6084/m9.figshare.24659106.v1
title: 20231130_starrydata2

description: All data on Starrydata2, a database of experimental properties in the field of inorganic materials
DOI: 10.6084/m9.figshare.20352759.v1
title: Contig Coverage

description: Coverage summary statistics of represenative contigs for each tick sample.
DOI: 10.6084/m9.figshare.14864802.v1
title: Supplementary Material for: Automated Detection and Diameter Estimation for Mouse Mesenteric Artery Using Semantic Segmentation

description: <b><i>Background:</i></b> Pressurized myography is useful for the assessment of small artery structures and function. However, this procedure requires technical expertise for sample preparation and effort to choose an appropriate sized artery. In this study, we developed an automatic artery/vein differentiation and a size measurement system utilizing machine learning algorithms. <b><i>Methods and Results:</i></b> We used 654 independent mouse mesenteric artery images for model training. The model yielded an Intersection-over-Union of 0.744 ± 0.031 and a Dice coefficient of 0.881 ± 0.016. The vessel size and lumen size calculated from the predicted vessel contours demonstrated a strong linear correlation with manually determined vessel sizes (<i>R</i> = 0.722 ± 0.048, <i>p</i> &lt; 0.001 for vessel size and <i>R</i> = 0.908 ± 0.027, <i>p</i> &lt; 0.001 for lumen size). Last, we assessed the relation between the vessel size before and after dissection using a pressurized myography system. We observed a strong positive correlation between the wall/lumen ratio before dissection and the lumen expansion ratio (<i>R</i> = 0.832, <i>p</i> &lt; 0.01). Using multivariate binary logistic regression, 2 models estimating whether the vessel met the size criteria (lumen size of 160–240 μm) were generated with an area under the receiver operating characteristic curve of 0.761 for the upper limit and 0.747 for the lower limit. <b><i>Conclusion:</i></b> The U-Net-based image analysis method could streamline the experimental approach.
DOI: 10.6084/m9.figshare.22637413.v1
title: HG005 PacBio Hifi

description: HG005 PacBio Hifi vcf 37x coverage
DOI: 10.6084/m9.figshare.5128177.v1
title: Supplementary Material for: How Well Do Customers of Direct-to-Consumer Personal Genomic Testing Services Comprehend Genetic Test Results? Findings from the Impact of Personal Genomics Study

description: <b><i>Aim:</i></b> To assess customer comprehension of health-related personal genomic testing (PGT) results. <b><i>Methods:</i></b> We presented sample reports of genetic results and examined responses to comprehension questions in 1,030 PGT customers (mean age: 46.7 years; 59.9% female; 79.0% college graduates; 14.9% non-White; 4.7% of Hispanic/Latino ethnicity). Sample reports presented a genetic risk for Alzheimer's disease and type 2 diabetes, carrier screening summary results for &gt;30 conditions, results for phenylketonuria and cystic fibrosis, and drug response results for a statin drug. Logistic regression was used to identify correlates of participant comprehension. <b><i>Results:</i></b> Participants exhibited high overall comprehension (mean score: 79.1% correct). The highest comprehension (range: 81.1-97.4% correct) was observed in the statin drug response and carrier screening summary results, and lower comprehension (range: 63.6-74.8% correct) on specific carrier screening results. Higher levels of numeracy, genetic knowledge, and education were significantly associated with greater comprehension. Older age (≥60 years) was associated with lower comprehension scores. <b><i>Conclusions:</i></b> Most customers accurately interpreted the health implications of PGT results; however, comprehension varied by demographic characteristics, numeracy and genetic knowledge, and types and format of the genetic information presented. Results suggest a need to tailor the presentation of PGT results by test type and customer characteristics.
DOI: 10.6084/m9.figshare.23826435.v1
title: Anexos Aplicación del marco de valor de ASCO para evaluar el valor clínico y económico de enzalutamida y apalutamida en etapas tempranas del cáncer de próstata en Colombia.docx

description: anexos del estudio <b>Aplicación del marco de valor de ASCO para evaluar el valor clínico y económico de enzalutamida y apalutamida en etapas tempranas del cáncer de próstata en </b><b>Colombia</b><br>
DOI: 10.6084/m9.figshare.24126180.v1
title: Supplementary Material for: Pan-Cancer Analysis of the Prognostic and Immunological Role of SMG5: A biomarker for cancers

description: Introduction: SMG5 is involved in tumor cell development and viewed as a potential target for immunotherapy. The purpose of this study was to systematically analyze the expression level, function and prognostic value of SMG5 in pan-cancers. Methods: Differential expression of SMG5 in normal and tumor tissues was analyzed using The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression database (GTEx) data. Survival analysis was performed by Kaplan-Meier (KM) method and Cox risk regression. The relationship between SMG5 expression and lymphocyte abundance, tumor cell immune infiltration level, molecular and immune subtypes, as well as immune checkpoints were analyzed by Tumor-immune system interactions database (TISIDB), Tumor Immune Estimation Resource (TIMER) and Sangerbox databases. The correlation between SMG5 and immune scores was studied using the Estimation of Stromal and Immune cells in Malignant Tumours using Expression data (ESTIMATE) algorithm. Further, drug sensitivity analysis of SMG5 with low-grade glioma (LGG) was conducted using the CellMiner database. Results: SMG5 was highly expressed in 23 tumors and only had a significant impact on the prognosis of patients with LGG only. In addition, in tumor microenvironment and tumor immune analysis, we found that the level of immune infiltration, tumor mutational load (TMB), microsatellite instability (MSI) and immune checkpoints of LGG were significantly correlated with SMG5 expression. Furthermore, SMG5 was significantly associated with immune scores, stromal scores and sensitivity of some drugs in LGG. Conclusion: SMG5 is differentially expressed in several cancers and is significantly associated with prognosis, immune microenvironment and immune checkpoints in LGG patients. Therefore, SMG5 could be a potential pan-cancer biomarker and an immunotherapeutic target for LGG.
DOI: 10.6084/m9.figshare.15123576.v1
title: Supplementary Material for: A History of Cerebrovascular Disease Is Independently Associated with Increased Morbidity and Mortality in Patients with COVID-19: A Cohort Study of 369,563 COVID-19 Cases in the USA

description: <b><i>Objectives:</i></b> We set out to evaluate the risk for severe coronavirus disease 2019 (COVID-19) infection and subsequent cerebrovascular disease (CVD) in the population with a prior diagnosis of CVD within the past 10 years. <b><i>Methods:</i></b> We utilized the TriNetX Analytics Network to query 369,563 CO­VID-19 cases up to December 30, 2020. We created 8 cohorts of patients with COVID-19 diagnosis based on a previous diagnosis of CVD. We measured the odds ratios, relative risks, risk differences for hospitalizations, ICU/critical care services, intubation, mortality, and CVD recurrence within 90 days of COVID-19 diagnosis, compared to a propensity-matched cohort with no prior history of CVD within 90 days of COVID-19 diagnosis. <b><i>Results:</i></b> 369,563 patients had a confirmed diagnosis of COVID-19 with a subset of 22,497 (6.09%) patients with a prior diagnosis of CVD within 10 years. All cohorts with a CVD diagnosis had an increased risk of hospitalization, critical care services, and mortality within 90 days of COVID-19 diagnosis. Additionally, the data demonstrate that any history of CVD is associated with significantly increased odds of subsequent CVD post-COVID-19 compared to a matched control. <b><i>Conclusions:</i></b> CVD, a known complication of CO­VID-19, is more frequent in patients with a prior history of CVD. Patients with any previous diagnosis of CVD are at higher risks of morbidity and mortality from COVID-19 infection. In patients admitted to the ED due to COVID-19 symptoms, these risk factors should be promptly identified as delayed or missed risk stratification and could lead to an ineffective and untimely diagnosis of subsequent CVD, which would lead to protracted hospitalization and poor prognosis.
DOI: 10.6084/m9.figshare.5189002
title: Error and anomaly detection for intra-participant time-series data

description: Identification of errors or anomalous values, collectively considered outliers, assists in exploring data or through removing outliers improves statistical analysis. In biomechanics, outlier detection methods have explored the ‘shape’ of the entire cycles, although exploring fewer points using a ‘moving-window’ may be advantageous. Hence, the aim was to develop a moving-window method for detecting trials with outliers in intra-participant time-series data. Outliers were detected through two stages for the strides (mean 38 cycles) from treadmill running. Cycles were removed in stage 1 for one-dimensional (spatial) outliers at each time point using the median absolute deviation, and in stage 2 for two-dimensional (spatial–temporal) outliers using a moving window standard deviation. Significance levels of the t-statistic were used for scaling. Fewer cycles were removed with smaller scaling and smaller window size, requiring more stringent scaling at stage 1 (mean 3.5 cycles removed for 0.0001 scaling) than at stage 2 (mean 2.6 cycles removed for 0.01 scaling with a window size of 1). Settings in the supplied Matlab code should be customised to each data set, and outliers assessed to justify whether to retain or remove those cycles. The method is effective in identifying trials with outliers in intra-participant time series data.
DOI: 10.6084/m9.figshare.5129332.v1
title: Supplementary Material for: Muscle Strength and Fitness in Pediatric Obesity: a Systematic Review from the European Childhood Obesity Group

description: The increasing prevalence of paediatric obesity and related metabolic complications has been mainly associated with lower aerobic fitness while less is known regarding potential musculoskeletal impairments. The purpose of the present systematic review was to report the evidence regarding muscular fitness in children and adolescents with obesity. A systematic article search was conducted between November 2014 and June 2015 using MEDLINE, EMBASE, CINAHL psycINFO, SPORTDiscus and SocINDEX. Articles published in English and reporting results on muscle strength and muscular fitness in children and adolescents aged 6 to 18 years were eligible. Of 548 identified titles, 36 studies were included for analyses. While laboratory-based studies described higher absolute muscular fitness in youth with obesity compared with their lean peers, these differences are negated when corrected for body weight and lean mass, then supporting field-based investigations. All interventional studies reviewed led to improved muscular fitness in youth with obesity. Children and adolescents with obesity display impaired muscular fitness compared to healthy-weight peers, which seems mainly due to factors such as excessive body weight and increased inertia of the body. Our analysis also points out the lack of information regarding the role of age, maturation or sex in the current literature and reveals that routinely used field tests analysing overall daily muscular fitness in children with obesity provide satisfactory results when compared to laboratory-based data.
DOI: 10.6084/m9.figshare.25834906.v1
title: Supplementary Material for: Emphysematous pyelonephritis in a patient on SGLT2 inhibitor therapy – a rare clinical case report

description: Introduction: Emphysematous pyelonephritis is a rare but potentially life-threatening urinary tract infection characterized by the formation of gas in the renal parenchyma, collecting system and perinephric tissue. The condition typically develops in patients with specific predisposing factors such as diabetes mellitus, congenital or acquired obstructive uropathies or individuals taking immunosuppressive agents. Rarely can the disease occur in patients with other predisposing factors, such as the use of SGLT2 inhibitors but this is quite uncommon. The incidence of urinary tract infections associated with their use is still debatable, but cases of emphysematous pyelonephritis associated with SGLT2 inhibitors have been described in medical literature. Case Presentation: We present a rare case of a patient with emphysematous pyelonephritis without classical risk factors for the disease, who was taking an SGLT2 inhibitor. Conclusion: Although the frequency of urinary tract infections following the use of SGLT2 inhibitors is relatively low, their widespread application for treatment of numerous socially significant diseases underscores the necessity for specialists to be aware with all potential risks associated with their use, including the development of severe urinary tract infections.