cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4139443
title: The spatial landscape of lung pathology during COVID-19 progression - processed IMC data

description: Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19). However thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking. We use high parameter imaging mass cytometry9 targeting the expression of 36 proteins, to investigate at single cell resolution, the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2. This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Neutrophil and macrophage infiltration are hallmarks of bacterial pneumonia and COVID-19, respectively. We provide evidence that SARS-CoV-2 infects predominantly alveolar epithelial cells and induces a localized hyper-inflammatory cell state associated with lung damage. By leveraging the temporal range of COVID-19 severe fatal disease in relation to the time of symptom onset, we observe increased macrophage extravasation, mesenchymal cells, and fibroblasts abundance concomitant with increased proximity between these cell types as the disease progresses, possibly as an attempt to repair the damaged lung tissue. This spatially resolved single-cell data allowed us to develop a biologically interpretable landscape of lung pathology from a structural, immunological and clinical standpoint. This spatial single-cell landscape enabled the pathophysiological characterization of the human lung from its macroscopic presentation to the single-cell, providing an important basis for the understanding of COVID-19, and lung pathology in general.
description: We make available binary masks delineating the position of cells in imaging mass cytometry data for all 23 samples, totaling 237 regions of lung tissue. In addition, a h5ad file with intensity values for all single-cells and their classification in clusters and meta-clusters is also available. Companion deposit to https://doi.org/10.5281/zenodo.4110560
DOI: 10.6084/m9.figshare.14305722
title: Synthesis and Characterization of Zinc Oxide Obtained by Combining Zinc Nitrate with Sodium Hydroxide in Polyol Medium

description: RESUMO Polyols as solvents are widely and successfully used in various methodologies to obtain zinc oxide nanostructures. One of the main reasons of using polyols is related to its capacity to prevent the agglomeration of ZnO nanoparticles during the synthesis and to promote a more stable colloidal solution of it. In this work it is presented, for the first time, the obtaining of nanostructured ZnO by a polyol mediated solvothermal synthesis using zinc nitrate as precursor. The combination of the zinc source with sodium hydroxide in a polyol medium with PVA as dispersing agent provided a simple process for obtaining nanostructured ZnO. The zinc oxide nanostructures obtained were characterized by UV-visible, XRD, FESEM, TEM, DLS and BET. As result, was obtained a wurtzite phase with hexagonal structure with crystallite size of 12 nm and, according to TEM micrographs, an average size of 14 nm, which was corroborated to other analyses.
DOI: 10.5281/zenodo.4139442
title: The spatial landscape of lung pathology during COVID-19 progression - processed IMC data

description: Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19). However thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking. We use high parameter imaging mass cytometry9 targeting the expression of 36 proteins, to investigate at single cell resolution, the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2. This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Neutrophil and macrophage infiltration are hallmarks of bacterial pneumonia and COVID-19, respectively. We provide evidence that SARS-CoV-2 infects predominantly alveolar epithelial cells and induces a localized hyper-inflammatory cell state associated with lung damage. By leveraging the temporal range of COVID-19 severe fatal disease in relation to the time of symptom onset, we observe increased macrophage extravasation, mesenchymal cells, and fibroblasts abundance concomitant with increased proximity between these cell types as the disease progresses, possibly as an attempt to repair the damaged lung tissue. This spatially resolved single-cell data allowed us to develop a biologically interpretable landscape of lung pathology from a structural, immunological and clinical standpoint. This spatial single-cell landscape enabled the pathophysiological characterization of the human lung from its macroscopic presentation to the single-cell, providing an important basis for the understanding of COVID-19, and lung pathology in general.
description: We make available binary masks delineating the position of cells in imaging mass cytometry data for all 23 samples, totaling 237 regions of lung tissue. In addition, a h5ad file with intensity values for all single-cells and their classification in clusters and meta-clusters is also available. Companion deposit to https://doi.org/10.5281/zenodo.4110560
DOI: 10.6084/m9.figshare.14305721
title: Application of Failure Criteria in Aeronautical Sandwich Structure Composites with a Central Hole Subjected to Bending Testing

description: Abstract This study aimeds at investigating the mechanical behavior of an E-glass fiber-reinforced epoxy resin of a laminated composite sandwich with honeycomb core and a central hole, used in the aeronautics industry submitted to bending loading. Three analytical failure models applied to laminated composites were compared in order to study the influence of stress concentration due to a central hole. The following criteria were assessed: Average Stress Criterion (ASC), Point Stress Criterion (PSC) and the Inherent Flaw Model (IFM). These models were applied to experimental data obtained in a four-point bending test in samples of the sandwich laminate. Finally, modifications on failure prediction models were proposed and appied in sandwich laminates with a central hole. The results obtained showed the applicability of the proposed formulation and that the suggested changes to the model more adequately fit it to the experimental data.
DOI: 10.6084/m9.figshare.14305719
title: Longitudinal, Transverse, and Torsional Free Vibrational and Mechanical Behavior of Silicon Nanotubes Using an Atomistic Model

description: Abstract Silicon nanotubes (SiNTs) have been successfully synthesized recently. Despite the wide potential applications of SiNTs, their mechanical properties are rarely reported. In this study, as the first step, the mechanical behavior of clamped-free single-walled silicon nanotubes (SWSiNTs) for both armchair and zigzag structures is investigated by using molecular dynamics (MD) simulations while the inter-atomic forces are described by the Tersoff-Brenner many-body potential energy function. Meanwhile, the results of the total strain energy are used to establish an expression for predicting Young’s modulus of the nanotubes. Afterward, the free vibrational analysis including torsional, longitudinal and transverse vibrations behavior of SWSiNTs with different diameters and lengths are investigated to report the corresponding fundamental frequencies as a significant design parameter. In this study, also, an important stress-strain parameter ratio is defined for vibration analyses named dynamic Young’s modulus. Thereafter, the natural frequencies that are obtained using the current atomistic model are successfully compared with those evaluated by the continuum mechanics model. It is concluded that the utilized approach can predict the frequencies with reasonable accuracy. Furthermore, the effects of geometry on the natural frequencies for both armchair and zigzag structures are examined. The obtained results provide valuable insights into the vibrational behavior of silicon-based nanotubes.
DOI: 10.6084/m9.figshare.14305717
title: Metallurgical and Electrochemical characterization of a Supermartensitic Steel

description: The pitting corrosion of supermartensitic stainless steel (SMSS) was studied in an aqueous solution of 0.1 mol/L NaCl using the scanning vibrating electrode technique (SVET) and cyclic voltammetry. The SMSS showed 0.9% of retained austenite, as verified by Mössbauer spectroscopy. Cuboidal TiN particles were identified on the steel surfaces, by using optical, scanning electron, and transmission microscopy, associated to Mg-Ca-Al rich precipitates. Pit nucleation was slow and only verified after 24 h, associated to TiN/CaO·MgO·Al2O3 complex inclusions, thus on original interdendritic spaces, where lower Cr content and the presence of inclusions are expected.
DOI: 10.17870/bathspa.12302732
title: Tarrare the Freak - 300 Word Statement

description: <i>Tarrare the Freak</i> is a project which negotiates a model of puppetry as a practice-based analytic to deepen understanding of ethical and historical issues within the medical humanities. The piece showcased at the Bristol Festival of Puppetry (Tobacco Factory Theatres, September 2015) and Suspense Festival, London (New Diorama Theatre, November 2015), and toured the UK in 2017 including a 3-week run at Wilton’s Music Hall, London.<br>This item contains the 300-Word Statement. <br><br><br>
DOI: 10.17870/bathspa.12302732.v2
title: Tarrare the Freak - 300 Word Statement

description: <i>Tarrare the Freak</i> is a project which negotiates a model of puppetry as a practice-based analytic to deepen understanding of ethical and historical issues within the medical humanities. The piece showcased at the Bristol Festival of Puppetry (Tobacco Factory Theatres, September 2015) and Suspense Festival, London (New Diorama Theatre, November 2015), and toured the UK in 2017 including a 3-week run at Wilton’s Music Hall, London.<br>This item contains the 300-Word Statement. <br><br><br>
DOI: 10.6084/m9.figshare.14305716
title: The Influence of Different Concentrations of a Natural Clay Material as Active Principle in Cosmetic Formulations

description: Abstract The clay minerals have characteristics and properties that allow their applicability in the cosmetic area, being incorporated into formulations as an active principle. Therefore, the aim of this work is characterizing and evaluating the influence of a clay from Miracema do Norte, Tocantins, Brazil, named Clay V, on the physicochemical characteristics of a hydrophilic gel of Aristoflex®, a copolymer of the neutralized acryloyldimethyltaurate and vinylpyrrolidone sulphonic acid. Clay V was decontaminated and characterized through microbiological evaluation, crystalline phases present by X-Ray Diffraction (XRD), chemical composition by X-Ray Fluorescence (XRF), thermogravimetric analysis (TGA) and granulometric distribution by sieving. Gels were prepared using Clay V with particles in the range ≤ 180 μm in three different concentrations: 1%, 3% and 5% (w/w) and a standard gel without clay. The formulations were evaluated according to organoleptic characteristics, pH, viscosity, spreadability and the centrifugation test. The microbiological evaluation showed that the clay sample is in compliance with the parameters established by the legislation. The following mineral phases were identified by XRD: kaolinite, illite, vermiculite and quartz, mainly composed of silica and alumina according to XRF. Thermal analysis showed that the clay has two thermal decomposition reactions, the largest being 547.6°C. The granulometric analysis identified that the largest fraction (63.22%) was of particles with sizes greater than 710 μm. The organoleptic characteristics presented by the formulations were suitable, with characteristic gel odor, homogeneous appearance, soft and refreshing texture and staining based on the concentration of Clay V used. The obtained pH values were within the range between 5.5 and 6.5, and it was verified that the gel has high spreadability, distributing evenly on the skin. The values obtained for viscosity showed that the formulations are non-Newtonian fluids with pseudoplastic behavior. The centrifugation test showed that the formulations are stable, with no phase separation. The results obtained with the tests showed that the natural clay V material is beneficial in cosmetic products and can be used for incorporation in cosmetic gel formulations of Aristoflex® type.
DOI: 10.17870/bathspa.12302732.v1
title: Tarrare the Freak - 300 Word Statement

description: <i>Tarrare the Freak</i> is a project which negotiates a model of puppetry as a practice-based analytic to deepen understanding of ethical and historical issues within the medical humanities. The piece showcased at the Bristol Festival of Puppetry (Tobacco Factory Theatres, September 2015) and Suspense Festival, London (New Diorama Theatre, November 2015), and toured the UK in 2017 including a 3-week run at Wilton’s Music Hall, London.<br>This item contains the 300-Word Statement. <br><br><br>
DOI: 10.6084/m9.figshare.14305715
title: Influence of Physical and Chemical Components on the Physical-Mechanical Properties of Ten Brazilian Wood Species

description: Abstract Wood offers a good combination of high strength and low density, but its complete characterization takes a long time. This study aimed to correlate apparent density, chemical component and porosity parameters with the physical and mechanical properties of the wood as an alternative route to reduce the time spent proposing equations to estimate each mechanical property. Ten tropical wood species were characterized in accordance with Brazilian Standards and chemical components were determined by the Klason method, and the porosity using mercury intrusion. Multivariate regression models were applied to the results of each species to find the relationships. Good results were obtained, such as the coefficient of determination and the analysis of variance, which indicated that the equations for 10 out of the 16 properties are significant. Therefore, the apparent density, chemical component and porosity parameters used reduce the time intervals much lower than the time test stipulated by the standard.
DOI: 10.6084/m9.figshare.14305712
title: Response of a DIN 18MnCrSiMo6-4 Continuous Cooling Bainitic Steel to Plasma Nitriding with a Nitrogen Rich Gas Composition

description: Abstract The use of continuous cooling bainitic steels can provide a more energy efficient manufacturing route. However, for their use in mechanical components like gears, it is necessary to improve their surface properties without impacting the core properties to guarantee reliable mechanical performance. The effect of temperature and time on the plasma nitriding response of a DIN 18MnCrSiMo6-4 steel was investigated. The plasma nitriding was performed for 3, 6 and 9 hours, at 400, 450, 500 and 550 °C, using a gas mixture composed of 76 vol.% nitrogen and 24 vol.% hydrogen. Samples were characterized before and after plasma nitriding concerning the microstructure, hardness and microhardness, fracture toughness, phase composition and residual stress states. Based on the results presented, layer growth constants (k) for different temperatures was determined. Moreover, it could be found that 500 °C gave the best results investigated here, as higher temperature took to core and surface hardness decrease. The nitrided samples with thicker compound layers presented a fracture behavior dominated by the formation of Palmqvist cracks. X-ray phase analysis indicated the formation of biphasic compound layer on the surface of all nitrided samples. The diffusion zone presented compressive residual stresses with highest values near the surface.
DOI: 10.6084/m9.figshare.14305710
title: Analysis of Spinel Based Inclusions During the Last Stage of The Steelmaking Process of SAE 52100

description: Abstract Al2O3 (alumina) and MgO·Al2O3 (spinel) inclusions cause valve obstruction (clogging) in continuous casting and can deteriorate the quality of the final product. In this context, industrial heats of the bearing steel SAE 52100 was examined. Samples were collected in the final steps of the steelmaking process, both after vacuum treatment and during continuous casting. A scanning electron microscope (SEM) equipped with a energy-dispersive spectrometer (EDS) and automated particle characterization analysis was used to characterize the inclusions present in the steel samples. Thermodynamic calculations were performed with the commercial software FactSageTM 7.2. Based on thermodynamic predictions, parameters such as solid fraction, liquid fraction, MgO saturation point of the slags, content of dissolved elements in steel (Al, Mg, Ca,...) and the construction of a phase stability diagram were determined. The results in this study showed a tendency for increase in MgO content in the inclusions with the decrease of �O and SiO2 contents in the slag, an increase of binary basicity (�O/%SiO2). It is verified that the MgO contents in the slag were close to the saturation, increasing the probability for the formation of inclusions rich in MgO and/or spinel. On the other hand, stability diagrams confirm the formation of spinel inclusions for each of the heats analyzed. During the final step of the steelmaking process, there is a tendency for re-oxidation, which is verified by an increase in the density of inclusions (or total oxygen TO values).
DOI: 10.6084/m9.figshare.14305707
title: Enhancement of the Photodegradative Potential of Polymer Composites Containing Babassu Fiber

description: Abstract Vegetable fibers are widely used as reinforcement in the production of composites. In this work, the photodegradative potential of polymer composites containing babassu fiber was characterized and evaluated. The fibers were extracted manually and immersed in a 10% NaOH solution (Mercerization). After drying, they were crushed and incorporated into the low-density polyethylene matrix in proportions of 5%, 10%, and 20% of the total mass of the composite. The composites were subjected to Scanning Electron Microscopy analysis (showed the incorporation of fibers into the polymeric matrix), Infrared Spectroscopy (the presence of fiber was observed with peaks at 3200-3600 cm-1, and 1596 cm-1-1036 cm-1), Mechanical Tests (with 20% fiber, there is a 44% decrease in tension, 48% in strain and 12% in Young's modulus) and Thermogravimetric Analysis (inicial fiber degradation starts between 220-337 °C, and matrix degradation between 333-550 °C). The composites were subjected to degradation processes by solar radiation and under artificial UV-B. Samples of oxy-biodegradable plastic bags were also degraded under the same degradation conditions of the composites. These results show that the materials used in the research, besides presenting an excellent degree of compatibilization, also reveal an improvement in the photodegradation potential of composites.
DOI: 10.6084/m9.figshare.14305704
title: Thermal, Morphological, and Mechanical Properties of Regular and Waxy Maize Starch Films Reinforced with Cellulose Nanofibers (CNF)

description: Abstract Biodegradable films were prepared using regular and waxy starch and reinforced with cellulose nanofibers (CNF) from eucalyptus. Both films were characterized by their optical, structural, barrier, thermal and mechanical properties. The films presented a homogeneous, smooth surface without bubbles or cracks and good handling characteristics. Both films showed a mixture of B and V-type diffraction patterns. The water solubility of the samples decreased after the incorporation of nanocellulose. The water vapor permeability for both sources significantly reduced after incorporating nanocellulose at 0.5% and 1%. It is possible to observe that the addition of CNF increased the thermal stability of the starch films. On the other hand, the incorporation of nanocellulose improved either the mechanical resistance of the starch films.
DOI: 10.6084/m9.figshare.14305703
title: Plasma Nitriding of ISO 5832-1 Stainless Steel with Intermittent Nitrogen Flow at 450°C

description: Abstract ISO 5832-1 stainless steel specimens were plasma nitrided at different nitrogen potentials. The main goal was to obtain the S-phase with different nitrogen concentrations and free of chromium-based precipitates. The control of nitrogen potential was made by pulsing the gas at predetermined times: 10/10, 05/15, 02/18, and 01/19, where the numbers represent the time in minutes that the nitrogen flow was kept on/off, respectively. For all pulsing conditions, the nitriding was carried out at 450 °C for 2 hours. After nitriding, specimens were characterized by means of optical (OM) and electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD) and microhardness. Results show that the nitrided layer thickness decreases with decreasing times of nitrogen pulse, and that lower times of nitrogen flow lead to lower precipitation of chromium nitrides. It can be thus concluded that the use of intermittent nitrogen flow is an alternative to control the nitrided layer in terms of thickness, hardness, and the amount of nitrogen present in phase ɣN (S-phase).
DOI: 10.6084/m9.figshare.14305698
title: Corrosion Susceptibility and Functionally Graded Properties of Ti-35Nb-4Sn Alloy Processed by Laser Remelting

description: The effect of laser remelting on the corrosion susceptibility and mechanical properties of Ti-35Nb-4Sn (mass%) alloy is investigated across the remelted track profile. In comparison to the cold-rolled microstructure of base metal, recrystallization of heat affected zone (HAZ) improved plastic energy absorption and pitting corrosion resistance, by the reduction of active sites for pit nucleation. In fusion zone, however, passivation was compromised by the formation of dendritic microstructure with Sn enriched interdendritic region, where preferential pitting corrosion occurred. Fusion zone was the most anodic region and presented a corrosion potential difference of 35 mV, in comparison to the adjacent and most cathodic HAZ. Electrochemical impedance analysis showed that spontaneous passivation was most effective in base metal, that developed a thicker and more compact passive film. Local increase in elastic modulus and microhardness of fusion zone shows that laser remelting is a viable processing route for the manufacturing of biomaterials with functionally graded properties.
DOI: 10.17870/bathspa.12340976
title: Tarrare the Freak Research Programme - 'History of Medicine and The Depraved Appetite of Tarrare the Freak'

description: <i>Tarrare the Freak</i> is a project which negotiates a model of puppetry as a practice-based analytic to deepen understanding of ethical and historical issues within the medical humanities. The piece showcased at the Bristol Festival of Puppetry (Tobacco Factory Theatres, September 2015) and Suspense Festival, London (New Diorama Theatre, November 2015), and toured the UK in 2017 including a 3-week run at Wilton’s Music Hall, London.<br><br>This item contains the Research Programme given to audience members at performances of <i>The Depraved Appetite of Tarrare the Freak</i> at the Bristol Festival of Puppetry (Tobacco Factory Theatres), 2-3 Sep 2015, and at Suspense Festival, London (New Diorama Theatre), 2-3 Nov 2015.<br><br>Content provided courtesy of Laura Purcell-Gates and Wattle & Daub Theatre. All images used with permission.