cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16900888
title: Additional file 13 of Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology

description: Additional file 13: Table S2. Significants test of the detected hydrolases.
DOI: 10.6084/m9.figshare.16900888.v1
title: Additional file 13 of Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology

description: Additional file 13: Table S2. Significants test of the detected hydrolases.
DOI: 10.6084/m9.figshare.16900891
title: Additional file 14 of Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology

description: Additional file 14: Table S3. Total proteins detected.
DOI: 10.6084/m9.figshare.16900891.v1
title: Additional file 14 of Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology

description: Additional file 14: Table S3. Total proteins detected.
DOI: 10.6084/m9.figshare.13642321
title: Additional file 2 of Parasitism of Aedes albopictus by Ascogregarina taiwanensis lowers its competitive ability against Aedes triseriatus

description: Additional file 2. Code.
DOI: 10.6084/m9.figshare.13642321.v1
title: Additional file 2 of Parasitism of Aedes albopictus by Ascogregarina taiwanensis lowers its competitive ability against Aedes triseriatus

description: Additional file 2. Code.
DOI: 10.6084/m9.figshare.13642324
title: Additional file 3 of Parasitism of Aedes albopictus by Ascogregarina taiwanensis lowers its competitive ability against Aedes triseriatus

description: Additional file 3. Generated data.
DOI: 10.6084/m9.figshare.13642324.v1
title: Additional file 3 of Parasitism of Aedes albopictus by Ascogregarina taiwanensis lowers its competitive ability against Aedes triseriatus

description: Additional file 3. Generated data.
DOI: 10.6084/m9.figshare.16901037
title: Additional file 17 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 17: Table S3. Vir protein similarities. Percentage identities between AB2/73 and other Ti plasmid Vir proteins.
DOI: 10.6084/m9.figshare.16901037.v1
title: Additional file 17 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 17: Table S3. Vir protein similarities. Percentage identities between AB2/73 and other Ti plasmid Vir proteins.
DOI: 10.6084/m9.figshare.16901040
title: Additional file 18 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 18: Table S4.R. etli plasmid p42a contains T-DNA border-like sequences. This table shows the annotation of a part of R. etli plasmid p42a, with in addition to the gene annotation derived from accession NC_007762 the locations of a number of sequences which (almost) match T-DNA border consensus sequences. Also notable is the presence of a NAD/NADP-octopine/nopaline-dehydrogenase-family-protein between two of these borders and the large number of insertion sequences.
DOI: 10.6084/m9.figshare.16901043
title: Additional file 19 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 19: Table S5. Table listing the presence or absence of a vir-box sequence (RYTNCANTTGNAAY) upstream of the virA gene.
DOI: 10.6084/m9.figshare.16901043.v1
title: Additional file 19 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 19: Table S5. Table listing the presence or absence of a vir-box sequence (RYTNCANTTGNAAY) upstream of the virA gene.
DOI: 10.6084/m9.figshare.16901052
title: Additional file 3 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 3: Table S1. List of genomes used for analyses. Genomes are listed which were used for protein clustering, species tree construction and building the gene presence heatmaps.
DOI: 10.6084/m9.figshare.16901052.v1
title: Additional file 3 of Complete genomic sequence and phylogenomics analysis of Agrobacterium strain AB2/73: a new Rhizobium species with a unique mega-Ti plasmid

description: Additional file 3: Table S1. List of genomes used for analyses. Genomes are listed which were used for protein clustering, species tree construction and building the gene presence heatmaps.
DOI: 10.6084/m9.figshare.16901103
title: Additional file 1 of Genome-wide screening of novel RT-qPCR reference genes for study of GLRaV-3 infection in wine grapes and refinement of an RNA isolation protocol for grape berries

description: Additional file 1: Table S1. Total RNA purity and concentration assessment of all samples examined in this study using NanoDrop 1000.
DOI: 10.6084/m9.figshare.16901103.v1
title: Additional file 1 of Genome-wide screening of novel RT-qPCR reference genes for study of GLRaV-3 infection in wine grapes and refinement of an RNA isolation protocol for grape berries

description: Additional file 1: Table S1. Total RNA purity and concentration assessment of all samples examined in this study using NanoDrop 1000.
DOI: 10.6084/m9.figshare.16901109
title: Additional file 3 of Genome-wide screening of novel RT-qPCR reference genes for study of GLRaV-3 infection in wine grapes and refinement of an RNA isolation protocol for grape berries

description: Additional file 3: Table S3. Candidate reference genes identified in RNA-Seq dataset of leaf samples as ordered by CV values of leaf. Table S4. Candidate reference genes identified in RNA-Seq dataset of berry samples as ordered by CV values of berry. Table S5. 2000 core candidate reference genes shared by leaf and berry RNA-Seq datasets, ranked by mean CV of CV_leaf and CV_berry.
DOI: 10.6084/m9.figshare.16901109.v1
title: Additional file 3 of Genome-wide screening of novel RT-qPCR reference genes for study of GLRaV-3 infection in wine grapes and refinement of an RNA isolation protocol for grape berries

description: Additional file 3: Table S3. Candidate reference genes identified in RNA-Seq dataset of leaf samples as ordered by CV values of leaf. Table S4. Candidate reference genes identified in RNA-Seq dataset of berry samples as ordered by CV values of berry. Table S5. 2000 core candidate reference genes shared by leaf and berry RNA-Seq datasets, ranked by mean CV of CV_leaf and CV_berry.
DOI: 10.6084/m9.figshare.16901112
title: Additional file 4 of Genome-wide screening of novel RT-qPCR reference genes for study of GLRaV-3 infection in wine grapes and refinement of an RNA isolation protocol for grape berries

description: Additional file 4: Table S6. Enriched KEGG pathways of 2000 core candidate reference genes.
DOI: 10.6084/m9.figshare.16901112.v1
title: Additional file 4 of Genome-wide screening of novel RT-qPCR reference genes for study of GLRaV-3 infection in wine grapes and refinement of an RNA isolation protocol for grape berries

description: Additional file 4: Table S6. Enriched KEGG pathways of 2000 core candidate reference genes.
DOI: 10.5519/qd.ii7huc8b
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (791 records)
DOI: 10.5517/ccdc.csd.cc24jkcm
title: CCDC 1982120: Experimental Crystal Structure Determination

description: Related Article: Sourav Mal, Manoranjan Jana|2021|J.Indian Chem.Soc.|98|100202|doi:10.1016/j.jics.2021.100202
DOI: 10.5517/ccdc.csd.cc26p1rq
title: CCDC 2046023: Experimental Crystal Structure Determination

description: Related Article: Haibo Huo, Weiqi Jiang, Feifei Sun, Jian Li, Baojun Shi|2021|Steroids|176|108931|doi:10.1016/j.steroids.2021.108931
DOI: 10.5517/ccdc.csd.cc26xhyl
title: CCDC 2053190: Experimental Crystal Structure Determination

description: Related Article: Zhichao Chen, Hong Zhang, Shu-Feng Zhou, Xiuling Cui|2021|Org.Lett.|23|7992|doi:10.1021/acs.orglett.1c02999
DOI: 10.5517/ccdc.csd.cc27t1bg
title: CCDC 2079645: Experimental Crystal Structure Determination

description: Related Article: Marta Lovisari, Robert Gericke, Brendan Twamley, Aidan R. McDonald|2021|Inorg.Chem.|60|15610|doi:10.1021/acs.inorgchem.1c02222
DOI: 10.5517/ccdc.csd.cc27vx12
title: CCDC 2081434: Experimental Crystal Structure Determination

description: Related Article: Samuele Ciceri, Diego Colombo, Patrizia Ferraboschi, Paride Grisenti, Marco Iannone, Matteo Mori, Fiorella Meneghetti|2021|Steroids|176|108928|doi:10.1016/j.steroids.2021.108928
DOI: 10.5517/ccdc.csd.cc27wkl9
title: CCDC 2082071: Experimental Crystal Structure Determination

description: Related Article: Narayan Sinha, Juan‐Ramón Jiménez, Björn Pfund, Alessandro Prescimone, Claude Piguet, Oliver S. Wenger|2021|Angew.Chem.,Int.Ed.|60|23722|doi:10.1002/anie.202106398
DOI: 10.5517/ccdc.csd.cc27zhsj
title: CCDC 2084898: Experimental Crystal Structure Determination

description: Related Article: E.A. Kravchenko, A.A. Gippius, S.V. Zhurenko, A.V. Tkachev, V.A. Semenova, A.V. Golubev, A.S. Kubasov, A.Yu. Bykov, G.A. Buzanov, K.Yu. Zhizhin, N.T. Kuznetsov|2021|Polyhedron|210|115514|doi:10.1016/j.poly.2021.115514
DOI: 10.5281/zenodo.5611986
title: Carbon Monitor - Global Daily CO2 Emissions in Near-Real-Time

description: <strong><em>Carbon Monitor: A near-real-time global daily CO2 emission dataset</em></strong> Carbon dioxide (CO<sub>2</sub>) emissions from the use of fossil fuels and the production of cement are the main driving force of climate change. Carbon Monitor is an international initiative providing for the first time regularly updated, science-based estimates of daily CO<sub>2</sub> emissions. Website: https://carbonmonitor.org Citation: Liu, Z., Ciais, P., Deng, Z. <em>et al.</em> Near-real-time monitoring of global CO<sub>2</sub> emissions reveals the effects of the COVID-19 pandemic. <em>Nat Commun</em> <strong>11, </strong>5172 (2020). https://doi.org/10.1038/s41467-020-18922-7 Data file description: Field Description country Brail, China, EU27 & UK, France, Germany, India, Italy, Japan, ROW, Russia, Spain, UK, US, WORLD * co2 CO2 emissions from fuel combustion and cement production process (unit: kt CO2) sector Power, Industry, Residential, Ground Transport, Domestic Aviation, International Aviation, International Shipping, Total **<sup>,</sup>*** date From 2019/1/1, every day * WORLD = China + US + EU27 & UK + India + Russia + Japan + Brazil + ROW + International Aviation (WORLD) + International Shipping (WORLD) ** Total (country level) = Power + Industry + Residential + Ground Transport + Domestic Aviation ** Total (WORLD) = Power + Industry + Residential + Ground Transport + Domestic Aviation + International Aviation + International Shipping
description: {"references": ["Liu, Z., Ciais, P., Deng, Z. et al. Near-real-time monitoring of global CO2 emissions reveals the effects of the COVID-19 pandemic. Nat Commun 11, 5172 (2020). https://doi.org/10.1038/s41467-020-18922-7", "Liu, Z., Ciais, P., Deng, Z. et al. Carbon Monitor, a near-real-time daily dataset of global CO2 emission from fossil fuel and cement production. Sci Data 7, 392 (2020). https://doi.org/10.1038/s41597-020-00708-7"]}
DOI: 10.5281/zenodo.5611985
title: Carbon Monitor - Global Daily CO2 Emissions in Near-Real-Time

description: <strong><em>Carbon Monitor: A near-real-time global daily CO2 emission dataset</em></strong> Carbon dioxide (CO<sub>2</sub>) emissions from the use of fossil fuels and the production of cement are the main driving force of climate change. Carbon Monitor is an international initiative providing for the first time regularly updated, science-based estimates of daily CO<sub>2</sub> emissions. Website: https://carbonmonitor.org Citation: Liu, Z., Ciais, P., Deng, Z. <em>et al.</em> Near-real-time monitoring of global CO<sub>2</sub> emissions reveals the effects of the COVID-19 pandemic. <em>Nat Commun</em> <strong>11, </strong>5172 (2020). https://doi.org/10.1038/s41467-020-18922-7 Data file description: Field Description country Brail, China, EU27 & UK, France, Germany, India, Italy, Japan, ROW, Russia, Spain, UK, US, WORLD * co2 CO2 emissions from fuel combustion and cement production process (unit: kt CO2) sector Power, Industry, Residential, Ground Transport, Domestic Aviation, International Aviation, International Shipping, Total **<sup>,</sup>*** date From 2019/1/1, every day * WORLD = China + US + EU27 & UK + India + Russia + Japan + Brazil + ROW + International Aviation (WORLD) + International Shipping (WORLD) ** Total (country level) = Power + Industry + Residential + Ground Transport + Domestic Aviation ** Total (WORLD) = Power + Industry + Residential + Ground Transport + Domestic Aviation + International Aviation + International Shipping
description: {"references": ["Liu, Z., Ciais, P., Deng, Z. et al. Near-real-time monitoring of global CO2 emissions reveals the effects of the COVID-19 pandemic. Nat Commun 11, 5172 (2020). https://doi.org/10.1038/s41467-020-18922-7", "Liu, Z., Ciais, P., Deng, Z. et al. Carbon Monitor, a near-real-time daily dataset of global CO2 emission from fossil fuel and cement production. Sci Data 7, 392 (2020). https://doi.org/10.1038/s41597-020-00708-7"]}
DOI: 10.25345/c5p26p
title: MassIVE MSV000088281 - MacMullanMA_NK-92_InterleukinSignaling
title: In these experiments, we stimulated cytokine starved NK-92 cells with interleukin(IL)-2 or IL-15 for 0, 5, 10, 15, or 30 minutes and investigated the resulting phospho-signaling.
DOI: 10.6084/m9.figshare.16879876
title: Data for ocean wave inversion based on the Doppler information

description: <br>The Doppler frequency shift and orbital velocity of the water waves is extracted from high-resolution airborne SAR data. The sea wave spectrum retrieved from line-of-sight velocity of wave and the in situ buoy measurement results.<br>
DOI: 10.5517/ccdc.csd.cc281bh5
title: CCDC 2086656: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc281bj6
title: CCDC 2086657: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc281bk7
title: CCDC 2086658: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc281bl8
title: CCDC 2086659: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc281bm9
title: CCDC 2086660: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc281bnb
title: CCDC 2086661: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc281bpc
title: CCDC 2086662: Experimental Crystal Structure Determination

description: Related Article: Wen-Chao Tu, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao|2021|Phytochemistry|193|112973|doi:10.1016/j.phytochem.2021.112973
DOI: 10.5517/ccdc.csd.cc286ppw
title: CCDC 2091808: Experimental Crystal Structure Determination

description: Related Article: Eugeny P. Ivakhnenko, Pavel A. Knyazev, Nikolay I. Omelichkin, Nadezhda I. Makarova, Andrey G. Starikov, Alexey E. Aleksandrov, Artem V. Ezhov, Alexey R. Tameev, Oleg P. Demidov, Vladimir I. Minkin|2021|Dyes Pigm.|197|109848|doi:10.1016/j.dyepig.2021.109848
DOI: 10.5517/ccdc.csd.cc28b683
title: CCDC 2095174: Experimental Crystal Structure Determination

description: Related Article: Kai-Wen Hu, Xiao You, Jin-Zheng Wang, Xiaoan Wen, Hongbin Sun, Qing-Long Xu, Zengwei Lai|2021|Org.Lett.|23|7873|doi:10.1021/acs.orglett.1c02889
DOI: 10.5517/ccdc.csd.cc28b694
title: CCDC 2095175: Experimental Crystal Structure Determination

description: Related Article: Kai-Wen Hu, Xiao You, Jin-Zheng Wang, Xiaoan Wen, Hongbin Sun, Qing-Long Xu, Zengwei Lai|2021|Org.Lett.|23|7873|doi:10.1021/acs.orglett.1c02889
DOI: 10.5517/ccdc.csd.cc28b6b5
title: CCDC 2095176: Experimental Crystal Structure Determination

description: Related Article: Kai-Wen Hu, Xiao You, Jin-Zheng Wang, Xiaoan Wen, Hongbin Sun, Qing-Long Xu, Zengwei Lai|2021|Org.Lett.|23|7873|doi:10.1021/acs.orglett.1c02889
DOI: 10.5517/ccdc.csd.cc28cwbw
title: CCDC 2096788: Experimental Crystal Structure Determination

description: Related Article: Xia Wang, Nvdan Hu, Wenlong Kong, Baoan Song, Shengkun Li|2022|Eur.J.Med.Chem.|227|113912|doi:10.1016/j.ejmech.2021.113912
DOI: 10.5517/ccdc.csd.cc24wg2l
title: CCDC 1992589: Experimental Crystal Structure Determination

description: Related Article: Xia Wang, Nvdan Hu, Wenlong Kong, Baoan Song, Shengkun Li|2022|Eur.J.Med.Chem.|227|113912|doi:10.1016/j.ejmech.2021.113912
DOI: 10.5517/ccdc.csd.cc28drgx
title: CCDC 2097629: Experimental Crystal Structure Determination

description: Related Article: Eun Bin Go, Lee Joon Kim, Hosea M. Nelson, Masao Ohashi, Yi Tang|2021|Org.Lett.|23|7819|doi:10.1021/acs.orglett.1c02836
DOI: 10.6084/m9.figshare.16616344.v1
title: Supplementary Material for: Association of polycythemia with outcomes of acute coronary syndrome

description: Medicine
DOI: 10.6084/m9.figshare.16616344
title: Supplementary Material for: Association of polycythemia with outcomes of acute coronary syndrome

description: Medicine
DOI: 10.6084/m9.figshare.16902664
title: Supplementary Material for: Decreases in Brain Size and Encephalization in Anatomically Modern Humans

description: Growth in human brain size and encephalization is well documented throughout much of prehistory and believed to be responsible for increasing cognitive faculties. Over the past 50,000 years, however, both body size and brain mass have decreased but little is known about the scaling relationship between the two. Here, changes to the human brain are examined using matched body remains to determine encephalization levels across an evolutionary timespan. The results find decreases to encephalization levels in modern humans as compared to earlier Holocene <i>H. sapiens</i> and Late Pleistocene anatomically modern <i>Homo</i>. When controlled for lean body mass, encephalization changes are isometric, suggesting that much of the declines in encephalization are driven by recent increases in obesity. A meta-review of genome-wide association studies finds some evidence for selective pressures acting on human cognitive ability, which may be an evolutionary consequence of the more than 5% loss in brain mass over the past 50,000 years.
DOI: 10.6084/m9.figshare.16902685
title: Supplementary Material for: Position Paper on the Value of Extended Adjuvant Therapy with Neratinib for Early HER2+/HR+ Breast Cancer

description: <b><i>Background:</i></b> In August 2018, neratinib – an oral, irreversible pan-HER-tyrosine-kinase inhibitor – was approved by the European Commission for the extended adjuvant treatment of adult patients with early-stage, hormone receptor-positive (HR+), HER2 overexpressed/amplified (HER2+) breast cancer who completed trastuzumab-based adjuvant therapy within the last year. Despite recent improvements in long-term outcome, there is still an unmet need to further reduce the risk of recurrence, especially in patients with poor response to neoadjuvant treatment. <b><i>Summary:</i></b> National and international guidelines included recommendations for using neratinib. Based on the health technology assessment for neratinib, the Federal Joint Committee (G-BA) in Germany has granted an added benefit for neratinib compared with the standard “watch and wait” strategies. Inclusion in the Reimbursement Code, however, was rejected by the Austrian social insurance companies in July 2020, and neratinib is now in the “No Box” for individual head physician reimbursement. <b><i>Key Messages:</i></b> We analysed the value of extended adjuvant therapy with neratinib in early HER2+/HR+ breast cancer based on current data and made recommendations for the evidence-based and economical use of neratinib in Austria. In particular, prognostic factors associated with an increased risk of recurrence following standard therapy are considered. Extended adjuvant therapy should be offered primarily to nodal-positive patients at surgery. For nodal-negative patients, neratinib therapy may be considered in case of large and/or inflammatory primary tumours (T3–4) without pathological complete response after neoadjuvant therapy. For all other patients, neratinib may be considered depending on additional risk factors on an individual basis that should be evaluated by interdisciplinary tumour conferences.
DOI: 10.6084/m9.figshare.16902685.v1
title: Supplementary Material for: Position Paper on the Value of Extended Adjuvant Therapy with Neratinib for Early HER2+/HR+ Breast Cancer

description: <b><i>Background:</i></b> In August 2018, neratinib – an oral, irreversible pan-HER-tyrosine-kinase inhibitor – was approved by the European Commission for the extended adjuvant treatment of adult patients with early-stage, hormone receptor-positive (HR+), HER2 overexpressed/amplified (HER2+) breast cancer who completed trastuzumab-based adjuvant therapy within the last year. Despite recent improvements in long-term outcome, there is still an unmet need to further reduce the risk of recurrence, especially in patients with poor response to neoadjuvant treatment. <b><i>Summary:</i></b> National and international guidelines included recommendations for using neratinib. Based on the health technology assessment for neratinib, the Federal Joint Committee (G-BA) in Germany has granted an added benefit for neratinib compared with the standard “watch and wait” strategies. Inclusion in the Reimbursement Code, however, was rejected by the Austrian social insurance companies in July 2020, and neratinib is now in the “No Box” for individual head physician reimbursement. <b><i>Key Messages:</i></b> We analysed the value of extended adjuvant therapy with neratinib in early HER2+/HR+ breast cancer based on current data and made recommendations for the evidence-based and economical use of neratinib in Austria. In particular, prognostic factors associated with an increased risk of recurrence following standard therapy are considered. Extended adjuvant therapy should be offered primarily to nodal-positive patients at surgery. For nodal-negative patients, neratinib therapy may be considered in case of large and/or inflammatory primary tumours (T3–4) without pathological complete response after neoadjuvant therapy. For all other patients, neratinib may be considered depending on additional risk factors on an individual basis that should be evaluated by interdisciplinary tumour conferences.