cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17141960
title: Supplementary Material for: Novel <b><i>SNX13</i></b> Frameshift Variant in an Individual with Developmental Delay

description: Recently, an increasing number of genes have been associated with global developmental delay (GDD) and intellectual disability (ID). The sorting nexin (SNX) protein family plays multiple roles in protein trafficking and intracellular signaling. SNXs have been reported to be associated with several disorders, including Alzheimer disease and Down syndrome. Despite the growing evidence of an association of SNXs with neurodegeneration, SNX13 deficiency has not been associated with GDD or ID. In this study, we present the case of a 4-year-old boy with brain dysplasia and GDD, including language delay, cognitive delay, and dyskinesia. Exome sequencing revealed a 1-bp homozygous deletion in <i>SNX13</i> (NM_015132.5: exon8: c.742_743del; p.Tyr248Leufs*20), which caused a frameshift and predicted early termination. Sanger sequencing confirmed that the variant was inherited from his parents respectively. Our findings associate <i>SNX13</i> variation with GDD for the first time and provide a new GDD candidate gene.
DOI: 10.5281/zenodo.5766156
title: msd-errors - Data for the LLZO figure

description: Data for the figure showing the diffusion and Arrhenius plots for a short simulation of LLZO. <br><br>Created using showyourwork from this GitHub repo.
DOI: 10.25934/pr00003645.0
title: Available IPD datapackage for study 'A Phase III Randomized, Double-blind, Parallel Group Study to Evaluate the Efficacy and Safety of Once Daily Oral Administration of BI 10773 25 mg/Linagliptin 5 mg and BI 10773 10 mg/Linagliptin 5 mg Fixed Dose Combination Tablets Compared With the Individual Components (BI 10773 25 mg, BI 10773 10 mg, and Linagliptin 5 mg) for 52 Weeks in Treatment naïve and Metformin Treated Patients With Type 2 Diabetes Mellitus With Insufficient Glycaemic Control'

description: This trial will evaluate use of BI 10773/linagliptin once daily (qd) fixed dose combination (FDC) in treatment naïve and metformin treated patients with type 2 diabetes mellitus to support approval by regulatory authorities.
DOI: 10.25934/pr00003641.1
title: Available IPD datapackage for study 'A Phase III Randomised, Double-blind, Placebo-controlled, Parallel Group, Efficacy and Safety Study of BI 10773 (10 mg, 25 mg) Administered Orally, Once Daily Over 12 Weeks in Hypertensive Patients With Type 2 Diabetes Mellitus'

description: This trial will evaluate safety and efficacy of BI 10773 in hypertensive patients with type 2 diabetes. Since hyperglycaemia and hypertension are key risk factors for both micro- and macrovascular complications, assessment of both glucose and blood pressure lowering effects of BI 10773 in hypertensive patients with type 2 diabetes could provide clinically highly relevant, new information for the use of BI 10773
DOI: 10.5281/zenodo.5766214
title: Deputados Federais Evangélicos de 1933 a 2018

description: Conjunto de dados dos deputados evangélicos eleitos desde 1933 a 2018. Este conjunto é um dos resultados da tese de Doutorado "Financiamento de Campanha Política da Bancada Evangélica da Câmara Federal: uma abordagem com o uso de Mineração de Dados".
DOI: 10.5281/zenodo.5766213
title: Deputados Federais Evangélicos de 1933 a 2018

description: Conjunto de dados dos deputados evangélicos eleitos desde 1933 a 2018. Este conjunto é um dos resultados da tese de Doutorado "Financiamento de Campanha Política da Bancada Evangélica da Câmara Federal: uma abordagem com o uso de Mineração de Dados".
DOI: 10.5517/ccdc.csd.cc28qr3w
title: CCDC 2107228: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qr4x
title: CCDC 2107229: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qr5y
title: CCDC 2107230: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qr6z
title: CCDC 2107231: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qr70
title: CCDC 2107232: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qr81
title: CCDC 2107233: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qr92
title: CCDC 2107234: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc28qrb3
title: CCDC 2107235: Experimental Crystal Structure Determination

description: Related Article: Matthew J. Evans, Mathew D. Anker, Michael G. Gardiner, Claire L. McMullin, Martyn P. Coles|2021|Inorg.Chem.|60|18423|doi:10.1021/acs.inorgchem.1c03012
DOI: 10.5517/ccdc.csd.cc25llhw
title: CCDC 2013868: Experimental Crystal Structure Determination

description: Related Article: Dongqiu Li, Fang Cheng, Yuhai Tang, Jing Li, Yang Li, Jiao Jiao, Silong Xu|2021|Org.Lett.|23|9030|doi:10.1021/acs.orglett.1c03206
DOI: 10.5517/ccdc.csd.cc28vwjk
title: CCDC 2111209: Experimental Crystal Structure Determination

description: Related Article: Qian Xiao, Maojian Lu, Yinglan Deng, Jing-Xin Jian, Qing-Xiao Tong, Jian-Ji Zhong|2021|Org.Lett.|23|9303|doi:10.1021/acs.orglett.1c03700
DOI: 10.5281/zenodo.5764913
title: Green Claims Dataset

description: This dataset contains 773 tweets of companies from the cosmetics and electronics domain. Each Tweets has a binary label as either a green claim or not green claim and a multi-class label as either Explicit green claim, Implicit green claim or Not green claim. Green claims are defined as "all appeals that include ecological, environmental sustainability, or nature-friendly messages that target the needs and desires of environmentally concerned stakeholders." An explicit green claim is different than an implicit green claim in that it is specific to certain products or processes of the company making the claim while implicit claims are vague in general and avoid any kind of commitments.
DOI: 10.5281/zenodo.5534902
title: Green Claims Dataset

description: This dataset contains 773 tweets of companies from the cosmetics and electronics domain. Each Tweets has a binary label as either a green claim or not green claim and a multi-class label as either Explicit green claim, Implicit green claim or Not green claim. Green claims are defined as "all appeals that include ecological, environmental sustainability, or nature-friendly messages that target the needs and desires of environmentally concerned stakeholders." An explicit green claim is different than an implicit green claim in that it is specific to certain products or processes of the company making the claim while implicit claims are vague in general and avoid any kind of commitments.
DOI: 10.6084/m9.figshare.17141975
title: 2D orthotropic metamaterial micorstructrue dataset

description: This database contains 90245 orthotropic microstructures represented by 50x50 pixelated matrices as well as the associated independent components of the stiffness tensor calculator by energy-based homogenization, i.e.,C11 ,C12 , C22 and C66. The microstructures are composed of void (air) and solid (Young’s modulus=1(normalized), Poisson’s ratio=0.35). We first performed SIMP-based TO to find a corresponding pixelated microstructure design for each uniformly sampled target stiffness matrix. With 1400 microstructures generated by TO as initial seeds, an iterative stochastic shape perturbation algorithm is employed to perturb microstructure geometries that correspond to extreme and sparse properties.
DOI: 10.5281/zenodo.5766212
title: Data and Code for 'Increased generalization in a peak procedure after delayed reinforcement'

description: This dataset comes from the paper Buritica, J., & Alcala, E. (2019). Increased generalization in a peak procedure after delayed reinforcement. <em>Behavioural processes</em>, 169, 103978. The data comes in raw files and processed files. Commented scripts are also provided. For information about its structure see the Readme file. <strong>License</strong> CC-BY-4.0
description: The research was funded by CONACyT INFR-281265
DOI: 10.5281/zenodo.5766211
title: Data and Code for 'Increased generalization in a peak procedure after delayed reinforcement'

description: This dataset comes from the paper Buritica, J., & Alcala, E. (2019). Increased generalization in a peak procedure after delayed reinforcement. <em>Behavioural processes</em>, 169, 103978. The data comes in raw files and processed files. Commented scripts are also provided. For information about its structure see the Readme file. <strong>License</strong> CC-BY-4.0
description: The research was funded by CONACyT INFR-281265
DOI: 10.5281/zenodo.5766274
title: msd-errors - Random walk data

description: The data related to the random walk components of the msd-error work, including truly random and temporarily anti-correlated random walks at a series of system and step size. These have either be analysed numerically or analytically (using kinisi).<br><br>Created using showyourwork from this GitHub repo.
DOI: 10.25934/pr00003632.0
title: Available IPD datapackage for study 'A Phase III, Randomized, Double-blind, Placebo-controlled, Parallel Group Safety and Efficacy Study of BI 10773 (10 mg and 25 mg Administered Orally Once Daily) During 52 Weeks in Patients With Type 2 Diabetes Mellitus and Insufficient Glycemic Control on MDI Insulin Regimen Alone or With Metformin'

description: This trial will evaluate use of BI 10773 as add-on to insulin regimen alone or with metformin in patients with typr 2 diabetes. Both lowering glucose and HbA1c and reducing the use of insulin in this population would provide significant new information for the BI 10773 use and would offer a potential new therapeutic option in this population.
DOI: 10.25934/pr00003623.1
title: Available IPD datapackage for study 'A Randomized, Double-blind, Placebo-controlled Parallel Group Efficacy and Safety Study of BI 1356 Over 24 Weeks in T2D Patients With Insufficient Glycaemic Control Despite Metformin Therapy'

description: In this randomised, double-blind, parallel group trial, the safety and efficacy of 5 mg of Linagliptin administered orally once daily will be compared with a placebo after 24 weeks of treatment as add-on therapy to metformin in patients with type 2 diabetes and insufficient glycaemic control.
DOI: 10.5281/zenodo.5766235
title: Chongce ice core stable isotopes and temperature reconstruction (1524-2012 A.D.)

description: Chongce ice core stable isotopes and temperature reconstruction
DOI: 10.5281/zenodo.5766234
title: Chongce ice core stable isotopes and temperature reconstruction (1524-2012 A.D.)

description: Chongce ice core stable isotopes and temperature reconstruction
DOI: 10.25345/c51s14
title: MassIVE MSV000088544 - In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM
title: PEDV Spike protein digested with trypsin and chymotrypsin was analyzed by LC-MS/MS.
DOI: 10.34740/kaggle/dsv/2901804
title: AutoXGB
DOI: 10.15151/esrf-es-540930166
title: CryoEM-BAG France: Structural Biology using Cryo-EM in France

description: This proposal gathers Principal investigators from French Institutions that use cryo-EM to unravel the molecular mechanisms associated with various biological processes. Scientists belong to 8 centres that currently use Cryo-EM and have already used ESRF CM01 beamline. All the PIs in this application have submitted application in the two previous Rolling access applications and have or will soon collect data. Most of them will thus need Beam-time prior to august 2020. According to our listing, 14 projects are ready for data collection at ESRF CM01. Projects include the study of bacterial secretion systems (Bordeaux, Lyon, Paris), viruses and their infection mechanisms (Marseille), translation and its control (Bordeaux, Toulouse, Paris, Strasbourg), transcription (Strasbourg, Paris) and Macromolecular transport (Bordeaux, Lyon, Strasbourg).
DOI: 10.6084/m9.figshare.16821427.v1
title: N-Omniglot

description: N-Omniglot is a large neuromorphic few-shot learning dataset. It reconstructs strokes of Omniglot as videos and uses Davis346 to capture the writing of the characters. The recordings can be displayed using DV software's playback function (https://inivation.gitlab.io/dv/dv-docs/docs/getting-started.html). N-Omniglot is sparse and has little similarity between frames. It can be used for event-driven pattern recognition, few-shot learning and stroke generation.It is a neuromorphic event dataset composed of 1623 handwritten characters obtained by the neuromorphic camera Davis346. Each type of character contains handwritten samples of 20 different participants. The file structure and sample can be found in the corresponding PNG file.
DOI: 10.5281/zenodo.5764258
title: Dataset for paper "Do Performance Aspirations Matter for Guiding Software Configuration Tuning? An Empirical Investigation under Dual Performance Objectives"

description: This contains the dataset matched with the code on the GitHub page: https://github.com/ideas-labo/aspiration-study.
DOI: 10.5281/zenodo.5764257
title: Dataset for paper "Do Performance Aspirations Matter for Guiding Software Configuration Tuning? An Empirical Investigation under Dual Performance Objectives"

description: This contains the dataset matched with the code on the GitHub page: https://github.com/ideas-labo/aspiration-study.
DOI: 10.6084/m9.figshare.17142299
title: Supplementary Material for: Evaluating Residual Cognition in Advanced Cognitive Impairment: The Residual Cognition Assessment

description: <b><i>Background:</i></b> In nursing homes, most of the patients with dementia are affected by severe cognitive disorder. Care interventions follow an accurate and recurring multidimensional assessment, including cognitive status. There is still a need to develop new performance-based scales for moderate-to-advanced dementia. <b><i>Objectives:</i></b> The development of the Residual Cognition Assessment (RCA) responds to the need to create new scales for global cognitive screening in advanced dementia, with some peculiar features: performance based, brief (&lt;5 m), available without specific training, and suitable for nonverbal patients with minimal distress. <b><i>Methods:</i></b> Two raters have administered the RCA and the Severe Impairment Battery-short version (SIB-S) to 84 participants with MMSE = 0. After 2–3 weeks, the same sample has been retested. The RCA has been also administered to 40 participants with MMSE 1–10 for a comparison. <b><i>Results:</i></b> The RCA has exhibited excellent values for test-retest reliability (intraclass correlation [ICC] = 0.956) as well as for inter-rater reliability (ICC = 0.997). The concurrent validity analyzes have shown strong correlations between the RCA and the SIB-S with ρ = 0.807 (<i>p</i> &lt; 0.01), and the RCA and the Clinical Dementia Rating (CDR) with ρ = −0.663 (<i>p</i> &lt; 0.01). Moderate correlation has been found between the RCA and the Functional Assessment Staging Scale with ρ = −0.435 (<i>p</i> &lt; 0.01). The instrument has showed high internal reliability, too (total: <i>α</i> = 0.899). The RCA has low floor effect (2%) with respect to the SIB-S (58%) but shows ceiling effect in the MMSE 1–10 sample (50%). The ROC curve analyses demonstrate that the RCA is acceptably able to discriminate between subjects with CDR 4/5 with an AUC of 0.92. Exploratory factor analysis shows 3 factors, defined as three major degrees of cognitive performance in advanced dementia, indeed hierarchically structured in three possible levels of decline. <b><i>Conclusions:</i></b> The RCA has showed excellent validity and reliability as well as good sensitivity to identify advanced cognitive impairment in dementia, without floor effect. The RCA seems complementary to the MMSE, so advisable when the latter reaches 0. Administration and scoring are simple, and only few minutes are required to assess the patient. The RCA can discriminate at least 3 different major stages in advanced dementias: severe, profound, and late.
DOI: 10.6084/m9.figshare.17142299.v1
title: Supplementary Material for: Evaluating Residual Cognition in Advanced Cognitive Impairment: The Residual Cognition Assessment

description: <b><i>Background:</i></b> In nursing homes, most of the patients with dementia are affected by severe cognitive disorder. Care interventions follow an accurate and recurring multidimensional assessment, including cognitive status. There is still a need to develop new performance-based scales for moderate-to-advanced dementia. <b><i>Objectives:</i></b> The development of the Residual Cognition Assessment (RCA) responds to the need to create new scales for global cognitive screening in advanced dementia, with some peculiar features: performance based, brief (&lt;5 m), available without specific training, and suitable for nonverbal patients with minimal distress. <b><i>Methods:</i></b> Two raters have administered the RCA and the Severe Impairment Battery-short version (SIB-S) to 84 participants with MMSE = 0. After 2–3 weeks, the same sample has been retested. The RCA has been also administered to 40 participants with MMSE 1–10 for a comparison. <b><i>Results:</i></b> The RCA has exhibited excellent values for test-retest reliability (intraclass correlation [ICC] = 0.956) as well as for inter-rater reliability (ICC = 0.997). The concurrent validity analyzes have shown strong correlations between the RCA and the SIB-S with ρ = 0.807 (<i>p</i> &lt; 0.01), and the RCA and the Clinical Dementia Rating (CDR) with ρ = −0.663 (<i>p</i> &lt; 0.01). Moderate correlation has been found between the RCA and the Functional Assessment Staging Scale with ρ = −0.435 (<i>p</i> &lt; 0.01). The instrument has showed high internal reliability, too (total: <i>α</i> = 0.899). The RCA has low floor effect (2%) with respect to the SIB-S (58%) but shows ceiling effect in the MMSE 1–10 sample (50%). The ROC curve analyses demonstrate that the RCA is acceptably able to discriminate between subjects with CDR 4/5 with an AUC of 0.92. Exploratory factor analysis shows 3 factors, defined as three major degrees of cognitive performance in advanced dementia, indeed hierarchically structured in three possible levels of decline. <b><i>Conclusions:</i></b> The RCA has showed excellent validity and reliability as well as good sensitivity to identify advanced cognitive impairment in dementia, without floor effect. The RCA seems complementary to the MMSE, so advisable when the latter reaches 0. Administration and scoring are simple, and only few minutes are required to assess the patient. The RCA can discriminate at least 3 different major stages in advanced dementias: severe, profound, and late.
DOI: 10.5281/zenodo.5204678
title: Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions

description: Polysaccharide utilization loci (PULs) in the human gut microbiome have critical roles in shaping human health and ecological dynamics. We develop a CRISPR-FnCpf1-RecT genome-editing tool to study 23 PULs in the highly abundant species <em>B. uniformis</em> (BU). We identify the glycan-degrading functions of multiple PULs and elucidate transcriptional coordination between PULs that enables the population to adapt to the loss of PULs. Exploiting a pooled BU mutant barcoding strategy, we demonstrate that the <em>in vitro</em> fitness and the colonization ability of BU in the murine gut is enhanced by deletion of specific PULs and modulated by glycan availability. We show that BU PULs can mediate complex glycan-dependent interactions with butyrate producers that depend on the mechanism of degradation and the butyrate producer glycan utilizing ability. In sum, PULs are major determinants of community dynamics and butyrate production and can provide a selective advantage or disadvantage depending on the nutritional landscape.
DOI: 10.5281/zenodo.5204677
title: Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions

description: Polysaccharide utilization loci (PULs) in the human gut microbiome have critical roles in shaping human health and ecological dynamics. We develop a CRISPR-FnCpf1-RecT genome-editing tool to study 23 PULs in the highly abundant species <em>B. uniformis</em> (BU). We identify the glycan-degrading functions of multiple PULs and elucidate transcriptional coordination between PULs that enables the population to adapt to the loss of PULs. Exploiting a pooled BU mutant barcoding strategy, we demonstrate that the <em>in vitro</em> fitness and the colonization ability of BU in the murine gut is enhanced by deletion of specific PULs and modulated by glycan availability. We show that BU PULs can mediate complex glycan-dependent interactions with butyrate producers that depend on the mechanism of degradation and the butyrate producer glycan utilizing ability. In sum, PULs are major determinants of community dynamics and butyrate production and can provide a selective advantage or disadvantage depending on the nutritional landscape.
DOI: 10.25919/4gag-ga96
title: Parkes observations for project P960 semester 2021OCTS_01

description: We aim to carry out receiver pointing and characterisation tests of Parkes receivers. Typically, these tests are carried out after the receiver package is installed, but time does not always allow for proper characterisation. Receivers for consideration include UWL, MARS and 13MM packages. In addition to cross-referencing C007 for flux calibration via pointing, we aim to conduct gain-elevation and system temperature experiments using the Moon, to ensure users of the Parkes Observatory have the most accurate information available for calibration purposes. We also wish to fully characterise the spectro-polarimetry response of the UWL and cryoPAF, by determining the Mueller Matrix for the receivers.
DOI: 10.25919/m3yh-1b65
title: Parkes observations for project P574 semester 2021OCTS_04

description: We request time to observe 260 pulsars regularly in order to provide the accurate ephemerides necessary for the detection and characterisation of gamma-ray pulsars with the Fermi satellite. The main science goals are to increase the number of known gamma-ray pulsars (both radio-loud and radio-quiet), to determine accurate pulse profiles, and to characterise their high energy (phase-resolved) spectra. In the radio, the observations will also allow us to investigate: neutron stars and pulsar emission via detecting glitches and determining pulse timing parameters; and the ISM via measuring and monitoring dispersion measures, Faraday rotation measures, and scintillation. To date, we are (co-)authors on over 90 papers arising from the collaboration and P574 data, including three which use UWL observations. The data have contributed to the PhD theses of students from Bordeaux, Manchester, Oxford, Stanford, and Swinburne.