cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30846959
title: Supplementary Material for: Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study

description: Background: Children with atopic dermatitis (AD) appear to have higher skin permeation, which may increase the risk of systemic adverse events following administration of potent topical corticosteroids, such as clobetasol propionate (CP). However, the assessment of dermal absorption in a controlled clinical trial in children is not feasible. Using model-based approaches, this study aimed to characterise stratum corneum (SC) and systemic exposure to CP following topical application of the cream formulation, and to investigate its effects on circulating cortisol levels and growth velocity in children with AD. 

Methods: Physiologically-based pharmacokinetic (PBPK) and pharmacokinetic-pharmacodynamic (PKPD) modelling were utilised to describe the dermal absorption of CP in a virtual cohort of paediatric patients (1 - &lt; 18 years old). Based on a skin impairment model for lesional and non-lesional skin, CP concentrations in the SC and in plasma were described over time. Simulation scenarios were then implemented to evaluate the effect of varying treatment conditions on the systemic exposure to CP, cortisol levels and growth velocity. Subsequently, clinical case scenarios were simulated to illustrate typical cases of AD in the paediatric population. 

Results: Surface area had the largest impact on the local and systemic concentrations of CP, while body site and age had a minor effect. When comparing similar surface areas and site of application, the dose, dosing regimen (o.d. vs. b.i.d.) and occlusion had no clinically relevant effect on the local and systemic exposure. Assuming a uniform application (1.2 mg/cm2), CP cream can be applied on up to 20% of the body surface area in children with AD over a period of 2 weeks. The short-term use of CP cream had no effect on the growth velocity of children with AD. 

Discussion: Surface area affected by AD should be considered when assessing the risk of systemic side effects. CP can be applied up to 20% of the BSA of a child (&gt; 1 year old) without clinically relevant changes to circulating cortisol levels. In contrast to the systemic effects of oral corticosteroids, the short-term use of CP has no impact the growth velocity of paediatric subjects with AD.
DOI: 10.6084/m9.figshare.30846959.v1
title: Supplementary Material for: Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study

description: Background: Children with atopic dermatitis (AD) appear to have higher skin permeation, which may increase the risk of systemic adverse events following administration of potent topical corticosteroids, such as clobetasol propionate (CP). However, the assessment of dermal absorption in a controlled clinical trial in children is not feasible. Using model-based approaches, this study aimed to characterise stratum corneum (SC) and systemic exposure to CP following topical application of the cream formulation, and to investigate its effects on circulating cortisol levels and growth velocity in children with AD. 

Methods: Physiologically-based pharmacokinetic (PBPK) and pharmacokinetic-pharmacodynamic (PKPD) modelling were utilised to describe the dermal absorption of CP in a virtual cohort of paediatric patients (1 - &lt; 18 years old). Based on a skin impairment model for lesional and non-lesional skin, CP concentrations in the SC and in plasma were described over time. Simulation scenarios were then implemented to evaluate the effect of varying treatment conditions on the systemic exposure to CP, cortisol levels and growth velocity. Subsequently, clinical case scenarios were simulated to illustrate typical cases of AD in the paediatric population. 

Results: Surface area had the largest impact on the local and systemic concentrations of CP, while body site and age had a minor effect. When comparing similar surface areas and site of application, the dose, dosing regimen (o.d. vs. b.i.d.) and occlusion had no clinically relevant effect on the local and systemic exposure. Assuming a uniform application (1.2 mg/cm2), CP cream can be applied on up to 20% of the body surface area in children with AD over a period of 2 weeks. The short-term use of CP cream had no effect on the growth velocity of children with AD. 

Discussion: Surface area affected by AD should be considered when assessing the risk of systemic side effects. CP can be applied up to 20% of the BSA of a child (&gt; 1 year old) without clinically relevant changes to circulating cortisol levels. In contrast to the systemic effects of oral corticosteroids, the short-term use of CP has no impact the growth velocity of paediatric subjects with AD.
DOI: 10.6084/m9.figshare.30846962
title: Supplementary Material for: Transcutaneous Retrobulbar Amphotericin B injection treatment for invasive fungal rhino-orbital sinusitis – case report

description: Introduction: Invasive fungal rhino-orbital sinusitis is a rare and life-threatening condition that occurs in immunosuppressed patients. This article aims to describe the case of a patient with bilateral orbital mucormycosis treated with right orbital exenteration and transcutaneous retrobulbar amphotericin B (AMPB) in the left orbit.
Case Presentation: A 61-year-old diabetic woman, immunosuppressed due to treatment with immunotherapy for breast cancer and systemic corticosteroid for sarcoidosis, was admitted to our hospital with complaints of severe headache, fever and complete right visual loss. Imaging exams demonstrated an invasive pansinusitis with right orbital apex involvement, extension to frontal cerebral space and an inflammatory swelling in the medial aspect of the left orbit with extra-conal extension. These findings corroborated the diagnosis of rhino-orbital mucormycosis with intracranial extension. Initial treatment included systemic antifungal therapy and necrotic tissue debridement, both encephalic and sinonasal. Since there was a complete right orbital apex and optic nerve involvement, she was treated with right orbital exenteration. The left eye presented good visual acuity (8/10 Snellen chart) and no signs of afferent or efferent pathway involvement. Regarding the left orbital soft tissue involvement, this patient was proposed to transcutaneous retrobulbar injections of 1 mL of 3.5mg/mL of amphotericin B. She received a total of 6 injections, with clinical stability and radiographic signs of improvement regarding the left orbital involvement of the infection.
Conclusion: Transcutaneous retrobulbar injection of AMPB seems to be a valid approach for specific cases of rhinosinus mucormycosis with orbital invasion, allowing for orbital preservation without compromising patient survival.
DOI: 10.6084/m9.figshare.30846962.v1
title: Supplementary Material for: Transcutaneous Retrobulbar Amphotericin B injection treatment for invasive fungal rhino-orbital sinusitis – case report

description: Introduction: Invasive fungal rhino-orbital sinusitis is a rare and life-threatening condition that occurs in immunosuppressed patients. This article aims to describe the case of a patient with bilateral orbital mucormycosis treated with right orbital exenteration and transcutaneous retrobulbar amphotericin B (AMPB) in the left orbit.
Case Presentation: A 61-year-old diabetic woman, immunosuppressed due to treatment with immunotherapy for breast cancer and systemic corticosteroid for sarcoidosis, was admitted to our hospital with complaints of severe headache, fever and complete right visual loss. Imaging exams demonstrated an invasive pansinusitis with right orbital apex involvement, extension to frontal cerebral space and an inflammatory swelling in the medial aspect of the left orbit with extra-conal extension. These findings corroborated the diagnosis of rhino-orbital mucormycosis with intracranial extension. Initial treatment included systemic antifungal therapy and necrotic tissue debridement, both encephalic and sinonasal. Since there was a complete right orbital apex and optic nerve involvement, she was treated with right orbital exenteration. The left eye presented good visual acuity (8/10 Snellen chart) and no signs of afferent or efferent pathway involvement. Regarding the left orbital soft tissue involvement, this patient was proposed to transcutaneous retrobulbar injections of 1 mL of 3.5mg/mL of amphotericin B. She received a total of 6 injections, with clinical stability and radiographic signs of improvement regarding the left orbital involvement of the infection.
Conclusion: Transcutaneous retrobulbar injection of AMPB seems to be a valid approach for specific cases of rhinosinus mucormycosis with orbital invasion, allowing for orbital preservation without compromising patient survival.
DOI: 10.6084/m9.figshare.30846965
title: Supplementary Material for: Polypharmacy following dementia diagnoses in Vietnam: results from real-world data in outpatient settings

description: Introduction: Polypharmacy might be clinically appropriate if it improves health outcomes of people with dementia. However, polypharmacy was associated with higher risks of impairment in cognitive, physical, and emotional abilities. Several studies on polypharmacy among people with dementia were performed globally, but not in Vietnam. This study aimed to investigate the epidemiology of polypharmacy among people with dementia in Vietnam.

Methods: This retrospective cohort study included outpatient individuals who were diagnosed with dementia between 01 January 2023 and 15 April 2024 in the Vietnam National Geriatric Hospital. Data was extracted from medical records, including dementia diagnosis, drug utilization, medical history before dementia diagnosis, comorbidities, and sociodemographic. The monthly quantity of drugs used was categorized as ‘no polypharmacy’ 0–4 drugs, ‘polypharmacy’ ≥5 drugs, and ‘hyperpolypharmacy’ ≥10 drugs. The primary outcome was the incidence of polypharmacy following dementia diagnosis. The prescription of potentially inappropriate medications in people with dementia, identified by using the American Geriatrics Society Beers criteria, was also evaluated. Multivariable logistic regression was employed to find associated risk factors of polypharmacy.

Results: During the follow-up from dementia diagnosis to 30 June 2024, there were 64 people having polypharmacy (median age at dementia diagnosis 73.5, 68.8% females) and 342 people without polypharmacy (median age at dementia diagnosis 74.0, 64.0% females). Age at dementia diagnosis, sex, regions of residence and education were not associated with having polypharmacy in people with dementia. Compared to people with Alzheimer’s disease, significantly higher probabilities of having polypharmacy were seen in people with vascular dementia (odds ratio (OR) 4.63, 95% confidence interval (CI) 2.16 – 9.92), and other dementias (OR 4.61, 95% CI 2.31 – 9.18). People with dementia at severe stage were at lower chance of having polypharmacy (OR 0.19, 95% CI 0.05 – 0.63). Potentially inappropriate medications were more frequent in the polypharmacy group (n = 27, 42.2%), compared to the non-polypharmacy group (n = 59, 17.3%). Prescribing antipsychotics in the polypharmacy group doubled that in the non-polypharmacy group (34.4% versus. 16.1%).

Discussion/Conclusion: Lower incidence of polypharmacy among people with dementia compared to previous studies might either imply the improvement in managing the prescription of potentially inappropriate medications or be underestimated by not including inpatient individuals. Future studies are necessary to clarify the impact of polypharmacy on health outcomes of people with dementia.
DOI: 10.6084/m9.figshare.30846965.v1
title: Supplementary Material for: Polypharmacy following dementia diagnoses in Vietnam: results from real-world data in outpatient settings

description: Introduction: Polypharmacy might be clinically appropriate if it improves health outcomes of people with dementia. However, polypharmacy was associated with higher risks of impairment in cognitive, physical, and emotional abilities. Several studies on polypharmacy among people with dementia were performed globally, but not in Vietnam. This study aimed to investigate the epidemiology of polypharmacy among people with dementia in Vietnam.

Methods: This retrospective cohort study included outpatient individuals who were diagnosed with dementia between 01 January 2023 and 15 April 2024 in the Vietnam National Geriatric Hospital. Data was extracted from medical records, including dementia diagnosis, drug utilization, medical history before dementia diagnosis, comorbidities, and sociodemographic. The monthly quantity of drugs used was categorized as ‘no polypharmacy’ 0–4 drugs, ‘polypharmacy’ ≥5 drugs, and ‘hyperpolypharmacy’ ≥10 drugs. The primary outcome was the incidence of polypharmacy following dementia diagnosis. The prescription of potentially inappropriate medications in people with dementia, identified by using the American Geriatrics Society Beers criteria, was also evaluated. Multivariable logistic regression was employed to find associated risk factors of polypharmacy.

Results: During the follow-up from dementia diagnosis to 30 June 2024, there were 64 people having polypharmacy (median age at dementia diagnosis 73.5, 68.8% females) and 342 people without polypharmacy (median age at dementia diagnosis 74.0, 64.0% females). Age at dementia diagnosis, sex, regions of residence and education were not associated with having polypharmacy in people with dementia. Compared to people with Alzheimer’s disease, significantly higher probabilities of having polypharmacy were seen in people with vascular dementia (odds ratio (OR) 4.63, 95% confidence interval (CI) 2.16 – 9.92), and other dementias (OR 4.61, 95% CI 2.31 – 9.18). People with dementia at severe stage were at lower chance of having polypharmacy (OR 0.19, 95% CI 0.05 – 0.63). Potentially inappropriate medications were more frequent in the polypharmacy group (n = 27, 42.2%), compared to the non-polypharmacy group (n = 59, 17.3%). Prescribing antipsychotics in the polypharmacy group doubled that in the non-polypharmacy group (34.4% versus. 16.1%).

Discussion/Conclusion: Lower incidence of polypharmacy among people with dementia compared to previous studies might either imply the improvement in managing the prescription of potentially inappropriate medications or be underestimated by not including inpatient individuals. Future studies are necessary to clarify the impact of polypharmacy on health outcomes of people with dementia.
DOI: 10.15468/dl.sz27sq
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 "and" : [
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 "HasGeospatialIssue is false",
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 "is one of (Fossil, Living Specimen)"
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 "DatasetKey is iNaturalist Research-grade Observations",
 "Country is United States of America",
 "Year is greater than or equal to 1984",
 "Year is less than or equal to 2024",
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}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044063-251120083545085/datasets/export for details.
DOI: 10.5281/zenodo.14037754
title: Calcium-rich parent materials enhance multiple soil functions and bacterial network complexity
DOI: 10.5281/zenodo.14037755
title: Calcium-rich parent materials enhance multiple soil functions and bacterial network complexity
DOI: 10.5880/gfz.lkut.2025.002
title: OpenBuildingMap

description: This data publication provides the OpenBuildingMap dataset, organized per zoom-level 6 Quadkey. The dataset provides information about the occupancy and height of individual buildings. The main purpose of this data collection is risk assessment for natural hazards, however it can be used by anyone in need of a building exposure dataset. 
 
Buildings play a critical role in understanding human settlement patterns and are essential for applications such as crisis management, urban planning, energy efficiency, and multi-hazard risk assessment. To address the need for comprehensive and accessible global building data, we introduce a dataset containing 2.7 billion building footprints, enriched with structured attributes such as occupancy type and height information classified using the GEM Building Taxonomy. This dataset is derived from the integration of the AI-derived Open Buildings and the Global ML Building Footprints datasets, and the crowdsourced OpenStreetMap, hence creating the most detailed and extensive building dataset to date. The quality of the dataset has been researched using intrinsic quality checks and external reference datasets, including cadaster data and the Global Human Settlement Layer. It is provided as a GeoPackage, to ensure it is easily accessible. 
 
This work has received funding from the European Union thought the Geo-INQUIRE project (GA 101058518), within the Research Infrastructures Programme of Horizon Europe.
DOI: 10.5880/gfz.fpxo.2025.003
title: Rheology of PDMS Korasilon fluids M used at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences, Potsdam, Germany

description: This dataset provides rheometric data of PDMS Korasilon® Fluids M used for analogue modelling at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences, Potsdam, Germany. 
The material samples have been analyzed at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences, Potsdam (HelTec) using an Anton Paar Physica MCR 301 rheometer in a plate-plate configuration at room temperature (21˚C). Rotational (controlled shear rate) tests with shear rates varying from 10^-4 to 10^-1 s^-1 were performed. 
 
According to our rheometric analysis, the material is Newtonian (n = 1) at strain rates below 1 s-1. The viscosities range from 10 to 2000 Pa s.
description: The data presented here are derived by rheometric testing using an Anton Paar Physica MCR 301 at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences, Potsdam (HelTec). We used a riffled plate-plate configuration (PP25/P2) with a 1 mm gap. Tests were performed at 21°C. 
 
Samples have been carefully prepared by the same person to obtain a homogeneous mixture and measured consistently following a consistent test protocol. After the introduction of the material into the measuring gap, the sample is allowed to relax for 360 s to remove residual stresses. Rotational tests with controlled shear rate (CSR tests) were performed at 19 different shear rates varying logarithmically from 10-4 to 10-1 s-1 and with respective interval lengths from 1000 to 10 s. Each sample was measured in triplicates to verify reproducibility and test intrinsic variability.
DOI: 10.5880/gfz.fpxo.2025.002
title: Rheology of PDMS Korasilon G20OH used at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences, Potsdam, Germany

description: This dataset provides rheometric data of the PDMS Korasilon G20OH used for analogue modelling at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences, Potsdam, Germany. 
 
The material sample has been analyzed at the Laboratory for Experimental Tectonics at GFZ Helmholtz Centre for Geosciences (HelTec) using an Anton Paar Physica MCR 301 rheometer in a cone-plate configuration at room temperature (21˚C). Rotational (controlled shear rate) tests with shear rates varying from 10^-4 to 10^-1 s^-1 were performed. 
 
According to our rheometric analysis, the material is quasi-Newtonian (n~1) at strain rates below 10^-2 s^-1 and weakly shear rate thinning above. The viscosity of G20OH is 1.6*10^4 Pa s.
DOI: 10.5880/gipp-mt.202127.1
title: Geophysical imaging of subsurface properties and magnetostratigraphy of sedimentary records

description: The Roter Kamm Crater is a 3.7-million-year-old meteoritic impact crater in the Sperrgebiet National Park in southern Namibia. The Sperrgebiet National Park, officially Tsau ǁKhaeb (Sperrgebiet) National Park, is a national park and former diamond mining area in southern Namibia. Since 1908 the public has had no access to the area and even when it was proclaimed a national park in 2008 most of the restrictions remained, leaving the environment mainly undisturbed and unexplored. 
 
The geophysical exploration of the Roter Kamm Crater can bring valuable information about its internal structure, as only a very limited number of geophysical studies had been carried out at this site. Prior gravimetry and (airborne-)magnetic measurements indicate a bowl-shaped anomaly underneath the crater with an estimated maximum sedimentary thickness of 400 m or higher. 
 
To be able to image the the crater infill appropriatly, two electromagnetic methods were applied: the Transient Electromagnetic (TEM) and the Audiomagnetotelluric (AMT) method. The AMT data set was planned as a complementary data set to the more extensive TEM data set to ensure the imaging of the lower boundary of the sedimentary infill. 
 
This data publication (10.5880/GIPP-MT.202127.1) encompasses a detailed report in pdf format with a description of the project, information on the experimental setup, data collection, instrumentation used, recording configuration and data quality. The folder structure and content of the data repository are described in detail in Ritter et al. (2019). Time-series data are provided in EMERALD format (Ritter et al., 2015).
description: The Geophysical Instrument Pool Potsdam (GIPP) provides field instruments for (temporary) seismological studies (both controlled source and earthquake seismology) and for magnetotelluric (electromagnetic) experiments. The GIPP is operated by the GFZ German Research Centre for Geosciences. The instrument facility is open for academic use. Instrument applications are evaluated and ranked by an external steering board. See Haberland and Ritter (2016) and https://www.gfz.de/gipp for more information.
DOI: 10.5880/fidgeo.2025.097
title: Relative Sensitivity Factors of 16O2H relative to 18O in deuterium-implanted spinel-structured oxides

description: Spinel-structured oxides (hereafter referred to as ‘spinels’) are a group of nominally anhydrous minerals characterized by a wide range of solid solutions. To allow the analysis of hydrogen in spinels by secondary ion mass spectrometry, Relative Sensitivity Factors (RSFs), which are typically matrix-dependent, need to be determined. Anticipating analysis of the OH- dimer rather than the H+ monomer, we present here RSF values of 16O2H relative to 18O for five natural spinels, including franklinite, Fe-bearing spinel, Mg-chromite, magnetite, and jacobsite. The Al2O3 content in the matrix of these crystals ranged from 0.09 wt% to 67.54 wt%. Our data indicate increasing RSF values with increasing Al2O3 content, from 2.76 x 10^20 to 2.72 x 10^21 atoms per cm3, with an RSD for two repeat analyses of about 4.3%. The increase of RSF with Al2O3 follows a second order polynomial form: RSF = 2.27x10^17 Al2O3^2 + 2.05 x10^19 Al2O3 + 3.02 x10^20. Further analyses at other instruments under different analytical conditions will be required to understand how robust the accuracy of these data can be considered. Expanded analyses of the here presented spinels, including depth-profiling, are reported in Zellmer et al. (2025).