cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22559839.v1
title: Supplementary Material for: Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney.

description: Introduction: While recent investigations show that klotho exerts reno-protective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage. Methods: The impacts of subcutaneous klotho supplementation on rats with subtotal nephrectomy were examined. Animals were divided into 3 groups: group1 (short remnant, SR): remnant kidney for 4 weeks, group 2 (long remnant, LR): remnant kidney for 12 weeks and group 3 (klotho supplementation: KL): klotho protein (20 μg/kg/day) supplementation on the remnant kidney. Blood pressure, blood and urine compositions with conventional methods such as enzyme-linked immunosorbent assay and radioimmunoassay, kidney histology and renal expressions of various genes were analyzed. In vitro studies were also performed to support in vivo findings. Results: Klotho protein supplementation decreased albuminuria (-43%), systolic blood pressure (-16%), fibroblast growth factor (FGF) 23 (-51%) and serum phosphate levels (-19%), renal angiotensin II concentration (-43%), fibrosis index (-70%), renal expressions of collagen I (-55%) and transforming growth factor β (-59%) (p&lt;0.05 for all). Klotho supplementation enhanced fractional excretion of phosphate (+45%), glomerular filtration rate (+76%), renal expressions of klotho (+148%), superoxide dismutase (+124%) and bone morphogenetic protein (BMP) 7 (+174%) (p&lt;0.05 for all). Conclusion: Our data indicated that klotho protein supplementation inactivated renal renin-angiotensin system, reducing blood pressure and albuminuria in remnant kidney. Furthermore, exogenous klotho protein supplementation elevated endogenous klotho expression to increase phosphate excretion with resultant reductions in FGF23 and serum phosphate. Finally, klotho supplementation reversed renal dysfunction and fibrosis in association with improved BMP7 in remnant kidney.
DOI: 10.6084/m9.figshare.14384522.v1
title: de Mendonca Oropouche.xlsx

description: Oropouche virus, analyse of vetor comptence.
DOI: 10.6084/m9.figshare.9817139.v1
title: Carpobrotus Data AJB 2019.xlsx

description: Data of growth (relative growth rate, RGR (day<sup>-1</sup>), total dry weight (g), and root to shoot ratio (RSR)), plant water content (PWC), composition of plant tissues (%C, %N, C/N, δ<sup>13</sup>C, Δ<sup>13</sup>C, and δ<sup>15</sup>N), and seasonal measurements throughout the experiment for the chlorophyll fluorescence and spectral reflectance parameters of <i>C. aff. acinaciformis</i> and <i>C. edulis</i> grown at two different nutrient conditions with no competition and in competition.<br>
DOI: 10.6084/m9.figshare.28738244.v9
title: Logic innovation

description: Logic innovation 9-pdf
DOI: 10.6084/m9.figshare.24785142.v1
title: Supplementary Material for: Abrocitinib Provides Rapid and Sustained Improvement in Skin Pain and Is Associated With Improved Quality of Life Outcomes in Adult and Adolescent Patients With Moderate-to-Severe Atopic Dermatitis

description: Background: Skin pain in atopic dermatitis (AD) increases with disease severity and is associated with substantial quality of life (QoL) burden. 
Objectives: To evaluate abrocitinib efficacy on skin pain and QoL in adults and adolescents with moderate-to-severe AD.
Methods: This post hoc analysis included data with abrocitinib administered as monotherapy (pooled phase 2b [NCT02780167] and phase 3 JADE MONO-1 [NCT03349060] and MONO-2 [NCT03575871]) or in combination with topical therapy (phase 3 JADE COMPARE [NCT03720470] and JADE TEEN [NCT03796676]). Patients received oral, once-daily abrocitinib 200 mg, abrocitinib 100 mg, or placebo for 12 or 16 weeks (JADE COMPARE). Skin pain was rated using the Pruritus and Symptoms Assessment for Atopic Dermatitis (PSAAD) skin pain Numerical Rating Scale (NRS) item (“How painful was your skin over the past 24 hours?”) on a scale from 0 (not painful) to 10 (extremely painful). Itch (Peak Pruritus NRS) and QoL (Dermatology Life Quality Index or Children’s Dermatology Life Quality Index) were assessed. Least squares mean (LSM) change from baseline was analyzed using mixed effects repeated measures modeling.
Results: A total of 1822 patients (monotherapy pool, n=942; JADE COMPARE, n=595; JADE TEEN; n=285) were analyzed. LSM change from baseline in PSAAD skin pain score was significantly greater with abrocitinib versus placebo from week 2 through week 12 or 16 across all 3 study populations and occurred in a dose-dependent manner. A greater proportion of patients achieved a ≥4-point improvement from baseline in PSAAD skin pain score with abrocitinib (200 mg and 100 mg) versus placebo in the monotherapy pool (56% and 38% vs 12%; week 12), JADE COMPARE (72% and 52% vs 26%; week 16), and JADE TEEN (51% and 60% vs 31%; week 12). Additionally, a greater proportion of patients achieved a stringent threshold of skin pain improvement (PSAAD skin pain score &lt;2) with abrocitinib versus placebo. Adults and adolescents who achieved a ≥4-point improvement in skin pain reported greater QoL improvement than those who did not achieve a ≥4-point improvement. A positive correlation (≥0.3) was observed between skin pain and QoL and separately between skin pain and itch across the 3 study populations.
Conclusion: Abrocitinib as monotherapy or in combination with topical therapy improved skin pain and was associated with improved QoL in both adults and adolescents with moderate-to-severe AD across all evaluated studies.
DOI: 10.6084/m9.figshare.27678540.v1
title: Metadata spreadsheet

description: Transcriptomic analysis revealed that differentially expressed genes in the absence of AoNmd5 were involved in carbohydrate metabolism, amino acid metabolism, lipid metabolism, transport and catabolism, energy metabolism, and translation.
DOI: 10.6084/m9.figshare.3410104.v3
title: Genetic Data for Alatina alata, a box jellyfish with a circumtropical distribution

description: Alignments and Tree file for data associated with the paper: "The Box Jellyfish Alatina alata Has a Circumtropical Distribution" by Jonathan W. Lawley1,2, Cheryl Lewis Ames2,3, Bastian Bentlage2, Angel Yanagihara4, Roger Goodwill5, Ehsan Kayal2, Kikiana Hurwitz5 and Allen G. Collins2,6<br>1 Departamento de Ecologia e Zoologia, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-970, Brazil2 Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013, USA3 Biological Sciences Graduate Program, University of Maryland, College Park, MD 20742, USA4 Department of Tropical Medicine, Medical Microbiology and Pharmacology John A. Burns School of Medicine, University of Hawai’i at Manoa, Honolulu, HI 96822, USA5 Department of Biology, Brigham Young University, Hawaii, Laie, HI 96792, USA6 National Systematics Laboratory of NOAA's Fisheries Service, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013, USA<br>
DOI: 10.6084/m9.figshare.7985456.v2
title: What format of treatment do patients with emotional disorders prefer and why? Implications for public mental health settings and policies

description: The data file contains information on patient format preferences (individual, group, or online) for psychological treatment.
DOI: 10.6084/m9.figshare.14213885.v1
title: Appendix 1 _ common decision-making models.docx

description: The common ethical decision-making models
DOI: 10.6084/m9.figshare.23552964.v4
title: The raw data of resting EEG of patients with prolonged disorders of consciousness

description: The dataset consists of resting-state electroencephalogram (EEG) data in dat format from 32 healthy individuals and 59 patients with consciousness disorders. Each data segment comprises 60 epochs, with each epoch lasting 2 seconds. There are 62 electrode points, and the sampling rate is 250 Hz.
DOI: 10.6084/m9.figshare.28682717.v1
title: Supplementary Material for: Clinical characteristics and outcomes of elderly COVID-19 patients admitted to ICU during Chinese Mainland’s Omicron Wave: A multicenter retrospective cohort study

description: Introduction: There is limited information on elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections. We aimed to describe the characteristics and outcomes of elderly patients with Omicron variant infections admitted to the intensive care unit (ICU) on the Chinese Mainland and to evaluate the risk factors associated with mortality in these patients. 
Methods: We conducted a multicenter retrospective study including elderly patients with SARS-CoV-2 infection who were admitted to the ICU from November 1, 2022, to February 11, 2023, on the Chinese Mainland. The primary objective of the study was to describe the characteristics and outcomes of elderly ICU patients with Omicron variant infections. The secondary objective was to evaluate the risk factors for mortality of these patients.
Results: We included 1605 patients aged 65 years or older diagnosed with severe or critical COVID-19 and admitted to ICUs in 59 hospitals across different areas of the Chinese Mainland. The median age was 78 years (P25–P75, 72–84), with male patients accounting for 1164/1605 (72.5%), and 1459/1605 (90.9%) of patients having at least one comorbidity. The median APACHE II scores and SOFA scores were 16 (P25–P75, 11–23) and 5 (P25–P75, 3–8), respectively. Among these patients, 553 (34.5%) were recovery discharged, 557 (34.7%) died in the ICUs, and 495 (30.8%) discharged voluntarily during therapy and were later confirmed dead after discharge. Multivariable logistics analysis indicated that older age, coinfection, high levels of white blood cell count, blood urea nitrogen, D-Dimer, and lactate at admission were against for recovery discharged.
Conclusions: Elderly patients infected with the Omicron variant of SARS-CoV-2 and admitted to the ICU had a considerable mortality rate. Better understanding of risk factors for mortality may improve clinical management and more rational allocation of limited medical resources during a COVID-19 surge.
DOI: 10.6084/m9.figshare.17131517.v1
title: 1 EFA

description: Exploratory Factor Analysis
DOI: 10.6084/m9.figshare.21343470.v1
title: 2nd times of test in caregiver

description: The second time home assessment was done by a caregiver.
DOI: 10.6084/m9.figshare.24800085.v3
title: Holographic 3D tracking for L. acidophilus, L. gasseri, L. casei Shirota, L. plantarum, and 37 5AS.

description: 3D tracking based on digital holographic microscopy in pH8 buffer, for L. acidophilus, L. gasseri, L. casei Shirota, L. plantarum, and 37 5AS.
DOI: 10.6084/m9.figshare.5241874.v1
title: Erratum: Prenatal Evaluation of the Fetal Conus Medullaris on a Routine Scan

description: <b><i>Objective:</i></b> To assess the ability to identify the conus medullaris (CM) and measure the conus-sacrum distance (CS distance) on a routine scan and the relationship with maternal and fetal factors. <b><i>Methods:</i></b> This was a prospective study. The assessment of the CM and the CS distance and the influence of the body mass index (BMI), gestational age (GA) and fetal position were analyzed. The correlation between the femur length (FL) and the GA with the CS distance was evaluated. <b><i>Results:</i></b> A total of 696 fetuses were analyzed. The CM could be visualized in 82.3% of the cases, and the CS distance could be analyzed in 81.2% of the cases. The CM assessment was statistically associated with BMI and fetal position but not with GA. The CS distance assessment was statistically associated with BMI and GA but not with fetal position. We determined a significant association between the FL/CS distance and between the GA/CS distance. <b><i>Conclusions:</i></b> Assessment of the CM is possible on most routine scans. The CS distance could be introduced to routine scans for the assessment of prenatal skin-covered spinal dysraphism. High BMI, advanced GA and breech presentation could be potential factors limiting the feasibility of evaluating the CM.
DOI: 10.6084/m9.figshare.993871.v1
title: Proportion of time spent by mice near urine from rats infected with Toxoplasma gondii vs urine from uninfected rats

description: Fresh: The data set provides information on the raw times (seconds) spent by individual mice in the bisect arm with fresh uninfected rat urine (control) vs. time spent in bisect with fresh urine from rats infected with Toxoplasma gondii (total trial time: 20 minutes). The preference score of Mouse 7 was identified as an outlier and was excluded from analyses. Aged: The data set provides information on the raw times (seconds) spent by individual mice in the bisect arm with aged (3 days) uninfected rat urine (control) vs. time spent in bisect with aged urine from rats infected with Toxoplasma gondii (total trial time: 20 minutes)
DOI: 10.6084/m9.figshare.28539779.v1
title: Supplementary Material from The near-resonance liquid sloshing under surge excitations: theory and experiment

description: ESM3_experiments_images_supside_part2.zip
DOI: 10.6084/m9.figshare.25610376.v1
title: Shotgun metagenomic analysis of microbiota dynamics during long-term backslopping fermentation of traditional fermented milk in a controlled laboratory environment

description: This study aimed to apply ultra-high-depth metagenomic sequencing to track the variations at both inter- and intra-population levels, representing macrodiversity and microdiversity, respectively, as well as the functional-level changes in naturally fermented milk microbiomes during a nine-month continuous fermentation process using the backslopping technique.
DOI: 10.6084/m9.figshare.5123527.v1
title: Supplementary Material for: ESI LC-MS and MS/MS Characterization of Antifungal Cyclic Lipopeptides Produced by <b><i>Bacillus subtilis </i></b>XF-1

description: <i>Bacillus subtilis</i> XF-1 (CGMCC No. 2357), a patent strain with good effects for controlling the clubroot of crucifer and many pathogenic fungi, was predicted to produce cyclic lipopeptide (CLP) antibiotics based on its genomic analysis. In this study, the CLPs were purified and determined with the following protocol: the supernatant of XF-1 cultivating mixture was firstly precipitated, then the precipitants were extracted with methanol and further separated by Sephadex LH-20 chromatography to test its antifungal activities. Fungi-inhibiting fractions were further characterized with LC/ESI-MS and LC/ESI-MS/MS. The results show that four molecular ion peaks [M+H]<sup>+</sup> (<i>m/z</i> 1,464, 1,478, 1,492 and 1,506) from fungi suppression fraction were identified as fengycin A with fatty acid of C<sub>16</sub>–C<sub>19</sub>, fengycin B (C<sub>14</sub>–C<sub>17</sub>), fengycin C (C<sub>15</sub>–C<sub>18</sub>), fengycin D (C<sub>15</sub>–C<sub>18</sub>) and fengycin S (C<sub>15</sub>–C<sub>18</sub>). Fengycin C (C<sub>15</sub> and C<sub>18</sub>), fengycin D (C<sub>15</sub>, C<sub>16</sub> and C<sub>18</sub>) and fengycin S (C<sub>15</sub>, C<sub>16</sub> and C<sub>18</sub>) were reported for the first time. The diversity of the fengycins that exist in this strain will help the elucidation of their biocontrol mechanisms.
DOI: 10.15468/dl.4fb8zz
title: Occurrence Download

description: A dataset containing 74 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Monochamus alternatus Hope, 1843"
 ]
}

 The dataset includes 74 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009592-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.4225/03/587dafea1cc63
title: Dataset: Time Series Indexing (TSI)

description: This is a dataset containing 1 million Satellite Image Time Series
DOI: 10.6084/m9.figshare.28112015.v1
title: Offensive Patterns and Performance Analysis in One-Possession Scenarios During the Last Minute and Overtime in the EuroLeague (data files for SPSS and Theme)

description: Este estudio analiza los patrones ofensivos y el rendimiento durante momentos críticos en el baloncesto masculino de élite, centrándose en escenarios de una sola posesión en el último minuto y las prórrogas de los partidos de la Euroliga. Utilizando una metodología observacional con herramientas estadísticas avanzadas (análisis de patrones T y pruebas de chi-cuadrado), se examinaron 709 acciones técnico-tácticas. Los resultados destacan la efectividad de los contraataques, las acciones con un mínimo de pases y las jugadas iniciadas por bases y pívots. Además, los tiros libres tras faltas del equipo contrario resultaron ser el desenlace exitoso más frecuente para los equipos que lideraban. Estos hallazgos ofrecen recomendaciones prácticas para optimizar estrategias ofensivas en situaciones de alta presiónEn el directorio se encuentran tres archivos. En el subdirectorio <b>Archivo SPSS/Datos</b> se incluye el archivo de la base de datos diseñado para su uso con el software IBM SPSS (Statistical Package for the Social Sciences). Por otro lado, en el subdirectorio <b>Archivos/THEME6</b> se encuentran dos archivos compatibles con el programa Theme 6 Edu para la búsqueda de T-Patterns. Si se utiliza Theme 5, será necesario añadir al archivo VVT el criterio "Inicio-Fin" con las categorías <code>:</code> y <code>&</code>. De no realizar esta modificación, el archivo no funcionará correctamente.---------------------------This study explores offensive patterns and performance during critical moments in elite men's basketball, focusing on one-possession scenarios in the last minute and overtime of EuroLeague games. Using an observational methodology with advanced statistical tools (T-Pattern analysis and chi-square tests), it examines 709 technical-tactical actions. The findings highlight the effectiveness of fast breaks, actions with minimal passing, and plays initiated by point guards and centers. Additionally, free throws following fouls by opponents emerged as the most common successful outcome for leading teams. These results provide actionable insights for optimizing offensive strategies under high-pressure conditions.In the directory, three files are available. The <b>Archivo SPSS/Datos</b> subdirectory contains the database file for use with IBM's Statistical Package for the Social Sciences (SPSS). Additionally, the <b>Archivos/THEME6</b> subdirectory includes two files compatible with the Theme 6 Edu software for T-Pattern analysis. If using Theme 5, the <code><strong>:</strong></code>and <code><strong>&</strong></code> categories must be added to the "Start-End" criterion in the VVT file. Without this adjustment, the file will not function properly.<br>
DOI: 10.6084/m9.figshare.25060217.v1
title: Pre-contact and post-colonial ecological legacies shape Surinamese rainforests

description: This dataset belongs to the <i>Ecology</i> manuscript (ECY23-0681) "Pre-contact and post-colonial ecological legacies shape Surinamese rainforests". <b>Table S1</b> contains radiocarbon dating results (uncalibrated and calibrated age ranges and 1 sigma errors). <br><b>Table S2 </b>contains the phytolith morphotypes used that were used in the data analyses and fig.2-3, their corresponding plant taxa and literature <br><b>Table S3</b> contains CROSS 1 sizes, the count of CROSS and bilobate morphotypes and its ratio. In bold are extended counts<br><b>Table S4 </b>shows the data used to create fig. 2, showing phytoliths in abundances (%) or as "present" and charcoal in volume (cm3/mm3)<br><b>Table S5 </b>shows the data used to create fig. 3, showing burned phytoliths (%), total arboreal phytoliths (%), the openess index, total palm abundances (%) and modern AGB estimates for surface samples (Avitabile et al., 2016; Hijmans et al., 2013).<br><b>Table S6</b> contains the raw phytolith data in abundances (%) or as noted as "present", when observed during an extended scan. <b>Abstract of the manuscript:</b><br>Disturbances in tropical forests can have long-lasting ecological impacts, but their manifestations (ecological legacies) in modern forests are uncertain. Many Amazonian forests bear the mark of past soil modifications, species enrichments and fire events, but the trajectories of ecological legacies from the pre-contact or post-colonial period remains relatively unexplored. We assessed the fire and vegetation history from 15 soil cores ranging from 0 to 10 km from a post-colonial Surinamese archaeological site. We show that: i) fires occurred from 96 BC to recent times and induced significant vegetation change, ii) persistent ecological legacies from pre-contact and post-colonial fire and deforestation practices were mainly within 1 km of the archaeological site, and iii) palm enrichment of <i>Attalea</i>, <i>Oenocarpus</i> and <i>Astrocaryum</i> occurrewithin 0 km, 1 km, and 8 km of the archaeological site, respectively. Our results challenge the notion of spatially extensive and persistent ecological legacies. Instead, our data indicate that the persistence and extent of ecological legacies is dependent on its timing, frequency, type, and intensity. Examining the mechanisms and manifestations of ecological legacies is crucial in assessing forest resilience and Indigenous and local land rights in the highly threatened Amazonian forests.
DOI: 10.6084/m9.figshare.27629043.v2
title: Supplementary Material for: Mineralocorticoid receptor antagonist combined with a SGLT2 inhibitor versus SGLT2 inhibitor alone in chronic kidney disease: a meta-analysis of randomized trials

description: Background: Sodium glucose co-transporter 2 inhibitors (SGLT2i) and mineralocorticoid receptor antagonists (MRAs) reduce the progression of kidney disease. Whether the combination of these agents provides additional benefits compared to SGLT2i alone is worth exploring using data from randomized trials designed for this purpose. 
Aims: To assess the randomized treatment effect of MRAs combined with SGLT2i vs SGLT2i alone on markers of kidney and cardiovascular health. 
Methods: Random-effects meta-analysis of randomized trials testing the combination of MRAs with SGLT2i vs SGLT2i alone on albuminuria, blood pressure, estimated glomerular filtration rate (eGFR) and serum potassium among patients with chronic kidney disease (CKD).
Results: Four randomized trials were included with a total of 272 patients with CKD: eGFR varying between 30 and 60 mL/min/1.73m2 and urinary albumin-to-creatinine ratio (UACR) between 90 and 500 mg/g, with &gt;60% having type 2 diabetes. Treatment with MRAs plus SGLT2i vs SGLT2i alone reduced UACR by -33.6% (-42.6 to -24.7%), P &lt;0.001, I2 =0%. MRAs plus SGLT2i vs SGLT2i alone reduced systolic blood pressure by -6.1 mmHg (-8.9 to -3.3) mmHg, eGFR by -3.4 mmHg (-5.2 to -1.6) mmHg, and increased serum potassium by +0.23 mmol/L (0.15 to 0.34) mmol/L; P &lt;0.001 for all, without significant heterogeneity between trials (I2 &lt;25%). 
Conclusion: In this meta-analysis, MRAs plus SGLT2i provided greater reductions in albuminuria and blood pressure compared to SGLT2i alone. Larger randomized trials with longer follow-up should test whether MRA/SGLT2i combination therapies improve cardiovascular and renal outcomes compared to SGLT2i alone.
DOI: 10.6084/m9.figshare.963548.v1
title: Kinesin-1 and microtubule gliding motility assay using heavy water

description: Speed measurements of the kinesin-1 and microtubule system using the gliding motility assay in varying types of heavy waters. Windows users can decompress the archive using 7-zip, http://7-zip.org/. *nix users can decompress the archive from the command line using: tar --lzma -xvf microtubule_data.tar.lzma