cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20307188
title: Quality water assessment of the Matadouro Stream, Ijuí, Rio Grande do Sul, by physicochemical parameters and the Allium cepa test

description: ABSTRACT Urban water resources are of great importance for the maintenance of the ecosystem and their quality needs to be evaluated to identify possible sources of contamination. The present study aimed to use the Allium cepa L. test and physical-chemical analysis to assess the water quality of stream Matadouro, Ijuí, Rio Grande do Sul. The collections were carried out in four places of the urban stream and the samples used for physical-chemical analysis and Allium cepa test. The following parameters were evaluated: biochemical oxygen demand, chemical oxygen demand, total phosphorus, ammoniacal nitrogen, suspended solids and surfactants, trophic state index, mitotic index, and chromosomal aberrations. With regard to physical-chemical analysis, point 2 had the most changes, while point 1 (spring), the indicators showed better water quality. The trophic state index presented an average value of 59.17, classifying the stream in eutrophic degree. The mitotic index analysis showed that all points had stimulation of cell proliferation. Chromosomal aberrations were verified in all samples, however, higher in point 4. The Allium cepa test showed possible cytotoxic and genotoxic potential and, associated with the physical-chemical parameters, proved to be a good tool for assessing water quality. This study indicated that the urban stream is impacted by the surrounding actions, especially those related to domestic pollutants.
DOI: 10.25919/yq5r-3711
title: Parkes observations for project P1101 semester 2022APRS_08

description: We propose to carry out fortnightly monitoring of a very active repeater, FRB~190520, with the Parkes UWL system. Our current observations show that FRB~190520 is not only the most active FRB that can be observed with Parkes, but also shows unique behaviour at 2 to 3 GHz frequency. This makes UWL the ideal instrument to carry out in-depth studies of this repeating FRB. With this program, we expect to detect a large sample of bursts from FRB~190520, and in collaboration with the FAST telescope we will study emission properties, fluence distributions and polarisation properties over an extremely wide bandwidth with high sensitivity.
DOI: 10.6084/m9.figshare.19968577.v1
title: Double plating technique for fixing tibial plateau leveling osteotomy and modified cranial closing wedge ostectomy of the tibia in a dog with cranial cruciate ligament disease and excessive plateau angle: case report

description: ABSTRACT Tibial plateau leveling osteotomy (TPLO) associated to cranial wedge closing ostectomy (CCWO) has been one of the best options to manage cranial cruciate ligament (CCL) disease and excessive tibial plateau angle (TPA) in large dogs, however, the complication rate is potentially high. It is believed that a more robust fixation is necessary to stabilize them and decrease the risk of implant failure. A 6-year-old male American Pit Bull, weighing 36kg, with 90-day history of right hind limb lameness, was diagnosed with CCL disease. Due to the excessive tibial plateau angle (42°), TPLO was associated with a modified CCWO using a double plating technique. A final TPA of 12⁰ was accomplished, and a restricted level of exercises and physiotherapy were recommended. The patient was followed monthly until the fifth month postoperatively, when radiographic bone consolidation and no lameness were observed. By the date of this submission, 3 years after the procedure, the owner has reported no complications. The double plating technique for fixing TPLO and modified CCWO proved to be effective for the treatment of CrCL deficiency in a large dog with an excessive TPA.
DOI: 10.6084/m9.figshare.19968577
title: Double plating technique for fixing tibial plateau leveling osteotomy and modified cranial closing wedge ostectomy of the tibia in a dog with cranial cruciate ligament disease and excessive plateau angle: case report

description: ABSTRACT Tibial plateau leveling osteotomy (TPLO) associated to cranial wedge closing ostectomy (CCWO) has been one of the best options to manage cranial cruciate ligament (CCL) disease and excessive tibial plateau angle (TPA) in large dogs, however, the complication rate is potentially high. It is believed that a more robust fixation is necessary to stabilize them and decrease the risk of implant failure. A 6-year-old male American Pit Bull, weighing 36kg, with 90-day history of right hind limb lameness, was diagnosed with CCL disease. Due to the excessive tibial plateau angle (42°), TPLO was associated with a modified CCWO using a double plating technique. A final TPA of 12⁰ was accomplished, and a restricted level of exercises and physiotherapy were recommended. The patient was followed monthly until the fifth month postoperatively, when radiographic bone consolidation and no lameness were observed. By the date of this submission, 3 years after the procedure, the owner has reported no complications. The double plating technique for fixing TPLO and modified CCWO proved to be effective for the treatment of CrCL deficiency in a large dog with an excessive TPA.
DOI: 10.6084/m9.figshare.20307210
title: The incorrect disposal of solid residues inside an operation room: an environmental, economic, and social problem

description: ABSTRACT The overproduction of waste in our population is a serious social problem. In the health system, this is even more worrisome as the risks are aggravated by dangerous residues which need complex management. The lack of information and training of health professionals and managers, cleaning staff and patients regarding these residues may even result in occupational health, impact the environment, and result in considerable economical costs. In this work, the generation process of health care waste in an Operation Room (OR) of a large hospital was investigated, analyzing weights and costs, through in-loco observation of the operation row to investigate how the disposal is done and unveil the weak points in the process. During 4 months, 55 surgical procedures were observed and the residues generated in 1,498 procedures were weighted, of which 92% were disposed of as infectious waste. Among the factors that favored incorrect disposal, the following stand out: room size and disposal of trash cans for common and infectious waste. Here we highlight the need for ongoing training and environmental education, and the need to incorporate social-environmental values into the healthcare waste management routine, as well as the promotion of sustainable actions in the hospital leading to environmental, social, and economic sustainability.
DOI: 10.6084/m9.figshare.20307210.v1
title: The incorrect disposal of solid residues inside an operation room: an environmental, economic, and social problem

description: ABSTRACT The overproduction of waste in our population is a serious social problem. In the health system, this is even more worrisome as the risks are aggravated by dangerous residues which need complex management. The lack of information and training of health professionals and managers, cleaning staff and patients regarding these residues may even result in occupational health, impact the environment, and result in considerable economical costs. In this work, the generation process of health care waste in an Operation Room (OR) of a large hospital was investigated, analyzing weights and costs, through in-loco observation of the operation row to investigate how the disposal is done and unveil the weak points in the process. During 4 months, 55 surgical procedures were observed and the residues generated in 1,498 procedures were weighted, of which 92% were disposed of as infectious waste. Among the factors that favored incorrect disposal, the following stand out: room size and disposal of trash cans for common and infectious waste. Here we highlight the need for ongoing training and environmental education, and the need to incorporate social-environmental values into the healthcare waste management routine, as well as the promotion of sustainable actions in the hospital leading to environmental, social, and economic sustainability.
DOI: 10.48370/ofd/ba8asi/5jhu7x
title: FMW_Peniophorella praetermissa_M_4327.JPG

description: :unav
DOI: 10.48370/ofd/ba8asi/tdhlkd
title: FMW_Peniophorella praetermissa_M_4327 (2).JPG

description: :unav
DOI: 10.48370/ofd/ba8asi
title: Peniophorella praetermissa (P. Karst.) K. H. Larss., 4327

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.19968544
title: Antibodies against Leptospira spp. in bovine serum samples from several Brazilian states analyzed in the period from 2007 to 2015

description: ABSTRACT Bovine leptospirosis assumes great economic importance since it affects several production aspects. Therefore, knowledge about the occurrence and distribution of this disease is fundamental to adopt the correct prevention measures. The present study aimed to evaluate the frequency of anti-Leptospira spp. antibodies in 24,483 bovine serum samples received between 2007 to 2015 from 21 Brazilian states. Of these, 8,643 (35.3%) were reagents in the microscopic agglutination test to one or more serovars of Leptospira spp. The most frequent serovars were Wolffi (61.47%), Tarassovi (9.62%) and Pomona (7.20%). Hardjo serovar presented a prevalence of 6.27%. Among the 21 states analyzed, the State of Pernambuco had the highest frequency with 88.24% and the State of São Paulo was the origin of the largest number of analyzed samples (13,838), with a frequency of 31.54% of reagents. The results demonstrate a high exposure to several serovars of Leptospira spp. in bovine species in Brazilian states, showing the importance of adopting prophylactic measures in order to reduce the risk of infection in this specie.
DOI: 10.6084/m9.figshare.19968544.v1
title: Antibodies against Leptospira spp. in bovine serum samples from several Brazilian states analyzed in the period from 2007 to 2015

description: ABSTRACT Bovine leptospirosis assumes great economic importance since it affects several production aspects. Therefore, knowledge about the occurrence and distribution of this disease is fundamental to adopt the correct prevention measures. The present study aimed to evaluate the frequency of anti-Leptospira spp. antibodies in 24,483 bovine serum samples received between 2007 to 2015 from 21 Brazilian states. Of these, 8,643 (35.3%) were reagents in the microscopic agglutination test to one or more serovars of Leptospira spp. The most frequent serovars were Wolffi (61.47%), Tarassovi (9.62%) and Pomona (7.20%). Hardjo serovar presented a prevalence of 6.27%. Among the 21 states analyzed, the State of Pernambuco had the highest frequency with 88.24% and the State of São Paulo was the origin of the largest number of analyzed samples (13,838), with a frequency of 31.54% of reagents. The results demonstrate a high exposure to several serovars of Leptospira spp. in bovine species in Brazilian states, showing the importance of adopting prophylactic measures in order to reduce the risk of infection in this specie.
DOI: 10.48370/ofd/txr91q/loojnw
title: FMW_Peniophorella praetermissa_M_4191.JPG

description: :unav
DOI: 10.48370/ofd/txr91q/0qdshc
title: FMW_Peniophorella praetermissa_M_4191 (3).JPG

description: :unav
DOI: 10.48370/ofd/txr91q/dvqlcc
title: FMW_Peniophorella praetermissa_M_4191 (2).JPG

description: :unav
DOI: 10.48370/ofd/txr91q
title: Peniophorella praetermissa (P. Karst.) K. H. Larss., 4191

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.20307233
title: Use of biorelevant dissolution media in dissolution tests as a predictive method of oral bioavailability

description: Abstract Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions. Many dissolution media described in pharmacopoeias are not predictive of bioavailability. Due to this, biorelevant media are used as an alternative to solve this problem. The objective of this work is to evaluate the relevance of biorelevant dissolution media to predict in vivo drug dissolution. For this, a bibliographic search was carried out in scientific databases. The search was first performed for articles verifying the physicochemical properties of human gastrointestinal fluids. Subsequently, a comparison was made between the properties of gastrointestinal fluids and those of biorelevant and pharmacopoeial media. Finally, the results of bioequivalence studies and dissolution profile tests in biorelevant media described in the literature were compared. The results revealed that there are a few publications that have analysed some physicochemical properties of gastrointestinal fluids. In addition, high variability was observed for some properties. Regarding the comparison of these properties with pharmacopoeial media and biorelevant media, the analysis showed that the biorelevant media are more similar to gastrointestinal fluids than the pharmacopoeial media. Finally, the in vitro dissolution profile results were similar to the results obtained in vivo. Thus, biorelevant media may be useful for analysing dissolution profiles.
DOI: 10.6084/m9.figshare.20307233.v1
title: Use of biorelevant dissolution media in dissolution tests as a predictive method of oral bioavailability

description: Abstract Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions. Many dissolution media described in pharmacopoeias are not predictive of bioavailability. Due to this, biorelevant media are used as an alternative to solve this problem. The objective of this work is to evaluate the relevance of biorelevant dissolution media to predict in vivo drug dissolution. For this, a bibliographic search was carried out in scientific databases. The search was first performed for articles verifying the physicochemical properties of human gastrointestinal fluids. Subsequently, a comparison was made between the properties of gastrointestinal fluids and those of biorelevant and pharmacopoeial media. Finally, the results of bioequivalence studies and dissolution profile tests in biorelevant media described in the literature were compared. The results revealed that there are a few publications that have analysed some physicochemical properties of gastrointestinal fluids. In addition, high variability was observed for some properties. Regarding the comparison of these properties with pharmacopoeial media and biorelevant media, the analysis showed that the biorelevant media are more similar to gastrointestinal fluids than the pharmacopoeial media. Finally, the in vitro dissolution profile results were similar to the results obtained in vivo. Thus, biorelevant media may be useful for analysing dissolution profiles.
DOI: 10.48370/ofd/jiz0qx/51xdlz
title: FMW_Peniophorella praetermissa_M_3755.JPG

description: :unav
DOI: 10.48370/ofd/jiz0qx/y57kao
title: FMW_Peniophorella praetermissa_M_3755 (2).JPG

description: :unav
DOI: 10.48370/ofd/jiz0qx
title: Peniophorella praetermissa (P. Karst.) K. H. Larss., 3755

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.20307240.v1
title: Effects of thymoquinone in a rat model of reserpine-induced depression

description: Abstract The objective of this study is to examine the antidepressant and antioxidant effects of thymoquinone (TQ) on reserpine-induced depression, and to investigate the antidepressant and antioxidant activity of combined treatment of TQ+citalopram. In total, 36 male Wistar rats were randomly divided into 6 groups: 1)control1, 2)control2, 3)reserpine, 4)reserpine+TQ 5)reserpine+citalopram and 6)reserpine+TQ+citalopram. Depression was induced by administering intraperitoneal reserpine of 0.2mg/kg/14days. For antidepressant effects, 10 mg/kg TQ and/or 10 mg/kg citalopram was administered intragastrically 30 minutes prior to the administration of reserpine. Rat behavior was examined using the Behavioral Test following the completion of treatment protocol. Total nitric oxide (NOx) levels, malondialdehyde (MDA) levels, total oxidants status (TOS), total antioxidant status (TAS) in brain cortex, plasma as well as brain cortex glutathione (GSH) and levels of plasma total sulfhydryl groups (RSH) were examined. Treatment with TQ ameliorated the reserpine-induced changes in the Behavioral Test (p&lt;0.05). TQ treatment significantly increased dopamine (DA) and noradrenaline (NA) expressions when compared to the R group (p&lt;0.01). Serotonin (5-HT) expression also increased significantly (p&lt;0.05). Brain cortex and plasma TOS, MDA and NOx levels decreased, whereas TAS, GSH and RSH levels increased (p&lt; 0.05). TQ has the ability to prevent depression induced by reserpine. The combination of TQ+citalopram can be used in the treatment of depression with a stronger antioxidant effect
DOI: 10.6084/m9.figshare.20307240
title: Effects of thymoquinone in a rat model of reserpine-induced depression

description: Abstract The objective of this study is to examine the antidepressant and antioxidant effects of thymoquinone (TQ) on reserpine-induced depression, and to investigate the antidepressant and antioxidant activity of combined treatment of TQ+citalopram. In total, 36 male Wistar rats were randomly divided into 6 groups: 1)control1, 2)control2, 3)reserpine, 4)reserpine+TQ 5)reserpine+citalopram and 6)reserpine+TQ+citalopram. Depression was induced by administering intraperitoneal reserpine of 0.2mg/kg/14days. For antidepressant effects, 10 mg/kg TQ and/or 10 mg/kg citalopram was administered intragastrically 30 minutes prior to the administration of reserpine. Rat behavior was examined using the Behavioral Test following the completion of treatment protocol. Total nitric oxide (NOx) levels, malondialdehyde (MDA) levels, total oxidants status (TOS), total antioxidant status (TAS) in brain cortex, plasma as well as brain cortex glutathione (GSH) and levels of plasma total sulfhydryl groups (RSH) were examined. Treatment with TQ ameliorated the reserpine-induced changes in the Behavioral Test (p&lt;0.05). TQ treatment significantly increased dopamine (DA) and noradrenaline (NA) expressions when compared to the R group (p&lt;0.01). Serotonin (5-HT) expression also increased significantly (p&lt;0.05). Brain cortex and plasma TOS, MDA and NOx levels decreased, whereas TAS, GSH and RSH levels increased (p&lt; 0.05). TQ has the ability to prevent depression induced by reserpine. The combination of TQ+citalopram can be used in the treatment of depression with a stronger antioxidant effect
DOI: 10.6084/m9.figshare.20307251
title: Evaluation of cyanobacterial blooms in water supply rivers from Joinville city

description: ABSTRACT The proliferation of cyanobacteria in waters, especially in rivers, is associated with anthropic action, wastewater from industries, agriculture, and the lack of basic sanitation. Many health problems occur due to the cyanotoxins produced by these microorganisms. The present study aimed to evaluate the densities of cyanobacteria and their possible correlations with physical-chemical parameters in waters from supply rivers of the city of Joinville, in order to verify which factors are involved in the growth of these organisms between the years 2015 to 2019. The amount of cyanobacteria cells per milliliter of water were analyzed from the last 5 years of the Cubatão and Piraí rivers, based on the certificates of analysis provided by the current water supply service of Joinville. It was found that the cyanobacteria density values increased in both rivers from the year 2018. The physical-chemical parameters analyzed showed a low correlation with the cyanobacteria density from 2015 to 2019 for the Cubatão and Piraí rivers. To understand this increase in cyanobacteria, other climatic factors such as precipitation and average annual temperature were studied. The expressive increase in precipitation in January 2018, followed by a period of reduced rainfall, in addition to the gradual rising temperature in recent years, might be related to this elevation in the density of cyanobacteria between 2018 and 2019, requiring monitoring of this evolution in the supply rivers of the Joinville city.
DOI: 10.6084/m9.figshare.20307251.v1
title: Evaluation of cyanobacterial blooms in water supply rivers from Joinville city

description: ABSTRACT The proliferation of cyanobacteria in waters, especially in rivers, is associated with anthropic action, wastewater from industries, agriculture, and the lack of basic sanitation. Many health problems occur due to the cyanotoxins produced by these microorganisms. The present study aimed to evaluate the densities of cyanobacteria and their possible correlations with physical-chemical parameters in waters from supply rivers of the city of Joinville, in order to verify which factors are involved in the growth of these organisms between the years 2015 to 2019. The amount of cyanobacteria cells per milliliter of water were analyzed from the last 5 years of the Cubatão and Piraí rivers, based on the certificates of analysis provided by the current water supply service of Joinville. It was found that the cyanobacteria density values increased in both rivers from the year 2018. The physical-chemical parameters analyzed showed a low correlation with the cyanobacteria density from 2015 to 2019 for the Cubatão and Piraí rivers. To understand this increase in cyanobacteria, other climatic factors such as precipitation and average annual temperature were studied. The expressive increase in precipitation in January 2018, followed by a period of reduced rainfall, in addition to the gradual rising temperature in recent years, might be related to this elevation in the density of cyanobacteria between 2018 and 2019, requiring monitoring of this evolution in the supply rivers of the Joinville city.
DOI: 10.6084/m9.figshare.19968557
title: Multiresistance and virulence factors of Staphylococcus aureus isolated from pigs

description: ABSTRACT The emergence of livestock-associated methicillin-resistant Staphylococcus aureus strains (LA-MRSA) and the potential role of pigs in the evolution of these strains has led to increased interest in research of these microorganisms. However, this has contributed to a lack of research in the isolation and characterization of methicillin-susceptible S. aureus strains (MSSA). In this study, the prevalence of S. aureus in pigs in the nursery and finishing stages were analyzed. The susceptibility profiles to antibiotics, tolerance to heavy metals, and biofilm production of the isolates were evaluated using phenotypic and genotypic techniques. A total of 1,250 colonies suggestive of Staphylococcus spp. were isolated from 128 pigs, of which 63.6% (n = 795) belonged to this microbial genus. Sixty-seven colonies isolated from 34 animals (26.5%) were confirmed as S. aureus (8.4%). No strains resistant to copper, zinc, or methicillin were detected; however, all strains presented a resistance profile to at least three different classes of antimicrobials and 21 produced biofilms. These data are of concern, as they indicate the need for increased surveillance in the use of antimicrobials as well as reinforce the importance of studies on MSSA strains.