cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.uqijcn
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013591-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vqxetm
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013630-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3dcbqa
title: Occurrence Download

description: A dataset containing 285049546 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aves",
 "Year is greater than or equal to 2000"
 ]
}

 The dataset includes 285049546 records from 1424 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013644-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fjnth6
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is (Table 1) Proportion of Toxoplasma gondii seropositive arctic foxes (Alopex lagopus) by age group and geographic area"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013763-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3t6pnq
title: Occurrence Download

description: A dataset containing 775 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Unknown evidence",
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Material sample"
 ]
 },
 "Geometry POLYGON((-116.63636 19.25435,-94.08432 19.25435,-94.08432 45.83844,-117.33398 44.67803,-114.52148 37.81586,-114.36258 35.09809,-116.63636 19.25435))",
 "TaxonKey is Acer grandidentatum Nutt. ex Torr. & A.Gray",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 775 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0062708-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h7zkfc
title: Occurrence Download

description: A dataset containing 151837930 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Archaea",
 "TaxonKey is Bacteria",
 "TaxonKey is Chromista",
 "TaxonKey is Fungi",
 "TaxonKey is Plantae",
 "TaxonKey is Protozoa",
 "TaxonKey is Viruses"
 ]
 },
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 151837930 records from 7882 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013748-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr25300
title: Structure of the bee venom toxin melittin with [(C5H5)Ru]+ fragment attached to the tryptophan residue
DOI: 10.13018/bmr25301
title: Ig1 domain of human obscurin
DOI: 10.15468/dl.7vv5ha
title: Occurrence Download

description: A dataset containing 457 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "PublishingOrg is d3978a37-635a-4ae3-bb85-7b4d41bc0b88",
 "RecordedBy is Jeroen van der Kooij",
 "TaxonKey is Bufo bufo"
 ]
}

 The dataset includes 457 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003279-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr25302
title: Solution NMR structure of a novel cysteine framework containing Conus peptide Mo3964
DOI: 10.5517/ccdc.csd.cc1n6fq0
title: CCDC 1525532: Experimental Crystal Structure Determination

description: Related Article: Zhi-Qiang Jiang, Fei Wang, Jian Zhang|2017|Yingyong Huaxue|34|1072|doi:10.11944/j.issn.1000-0518.2017.09.170183
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1n6fr1
title: CCDC 1525533: Experimental Crystal Structure Determination

description: Related Article: Zhi-Qiang Jiang, Fei Wang, Jian Zhang|2017|Yingyong Huaxue|34|1072|doi:10.11944/j.issn.1000-0518.2017.09.170183
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25303
title: Titin M10 bound to obscurin ig1
DOI: 10.5517/ccdc.csd.cc2f078z
title: CCDC 2234550: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.31417568
title: <b>L</b><b>oss</b><b> of DNA methyltransferase 3a enhances </b><b>Caspase-8</b><b> transcription and promote</b><b>s</b><b> cardiomyocyte pyroptosis during myocardial infarction</b>

description: Aspartate-specific cysteine protease (Caspase)-8 plays a critical role in initiating pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD) during Yersinia infection. However, the role of Caspase-8 in pyroptosis after myocardial infarction (MI) and its underlying mechanism remains elusive. Herein we reported Caspase-8 is essential for cardiomyocyte pyroptosis post MI and Caspase-8/GSDMD signaling pathway is obviously activated in the infarcted hearts. The inhibition of Caspase-8 rescued the decline of cardiac function, myocardium injury and cardiomyocyte pyroptosis in MI mice. Conversely, forced expression of Caspase-8 aggravated cardiac injury in mice. Cardiomyocyte-specific knockout of GSDMD blunted the damage effects of Caspase-8 overexpression on cardiac function in mice. Bisulfite Sequencing PCR (BSP) analysis of infarcted hearts showed a CpG island with significantly reduced methylation levels near the Caspase-8 transcription start site (TSS). Methylated modification of this locus was mediated by DNMT3a, and negatively regulated Caspase-8 expression. In vivo, overexpression of DNMT3a alleviated cardiac function decline and cardiomyocyte pyroptosis by suppressing Caspase-8 in MI mice. Furthermore, the reduction of DNMT3a during MI was attributed to the increased ubiquitination. Demethylation of this locus obtained more opportunity of transcription factor (TF) binding like as HES1. Our study uncovers a novel regulatory axis, DNMT3a/Caspase-8/GSDMD, which drives post-MI cardiac injury by promoting cardiomyocyte pyroptosis, and suggested new therapeutic targets for ischemic heart diseases.
DOI: 10.6084/m9.figshare.31417568.v1
title: <b>L</b><b>oss</b><b> of DNA methyltransferase 3a enhances </b><b>Caspase-8</b><b> transcription and promote</b><b>s</b><b> cardiomyocyte pyroptosis during myocardial infarction</b>

description: Aspartate-specific cysteine protease (Caspase)-8 plays a critical role in initiating pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD) during Yersinia infection. However, the role of Caspase-8 in pyroptosis after myocardial infarction (MI) and its underlying mechanism remains elusive. Herein we reported Caspase-8 is essential for cardiomyocyte pyroptosis post MI and Caspase-8/GSDMD signaling pathway is obviously activated in the infarcted hearts. The inhibition of Caspase-8 rescued the decline of cardiac function, myocardium injury and cardiomyocyte pyroptosis in MI mice. Conversely, forced expression of Caspase-8 aggravated cardiac injury in mice. Cardiomyocyte-specific knockout of GSDMD blunted the damage effects of Caspase-8 overexpression on cardiac function in mice. Bisulfite Sequencing PCR (BSP) analysis of infarcted hearts showed a CpG island with significantly reduced methylation levels near the Caspase-8 transcription start site (TSS). Methylated modification of this locus was mediated by DNMT3a, and negatively regulated Caspase-8 expression. In vivo, overexpression of DNMT3a alleviated cardiac function decline and cardiomyocyte pyroptosis by suppressing Caspase-8 in MI mice. Furthermore, the reduction of DNMT3a during MI was attributed to the increased ubiquitination. Demethylation of this locus obtained more opportunity of transcription factor (TF) binding like as HES1. Our study uncovers a novel regulatory axis, DNMT3a/Caspase-8/GSDMD, which drives post-MI cardiac injury by promoting cardiomyocyte pyroptosis, and suggested new therapeutic targets for ischemic heart diseases.
DOI: 10.5517/ccdc.csd.cc2f07d3
title: CCDC 2234554: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25304
title: obscurin Ig1 bound to titin M10
DOI: 10.21942/uva.31422320
title: Data

description: Processed data for the manuscript "Effects of expectation, attention, and NMDA receptor blockade on feedforward and feedback processing" published in the Journal of Neuroscience.Link to the raw data: https://doi.org/10.21942/uva.28684382VAS: exp2_VAS_dataBehavior: taskRel_behavioral_dataEEG: taskRel_raw_EEG_data<br><br>
DOI: 10.21942/uva.31422320.v1
title: Data

description: Processed data for the manuscript "Effects of expectation, attention, and NMDA receptor blockade on feedforward and feedback processing" published in the Journal of Neuroscience.Link to the raw data: https://doi.org/10.21942/uva.28684382VAS: exp2_VAS_dataBehavior: taskRel_behavioral_dataEEG: taskRel_raw_EEG_data<br><br>
DOI: 10.5517/ccdc.csd.cc2f07f4
title: CCDC 2234555: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f082t
title: CCDC 2234575: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25305
title: titin M10 domain
DOI: 10.5517/ccdc.csd.cc2gkqpg
title: CCDC 2281156: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f07b1
title: CCDC 2234552: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25306
title: 1H, 13C and 15N chemical shift assignments for Oscillatoria agardhii agglutinin
DOI: 10.5517/ccdc.csd.cc2fhymj
title: CCDC 2249658: Experimental Crystal Structure Determination

description: Related Article: Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie|2023|J.Am.Chem.Soc.|145|26756|doi:10.1021/jacs.3c08796
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jmng9
title: CCDC 2342591: Experimental Crystal Structure Determination

description: Related Article: Yu-He Xu,  Xing Yang,  Ya-Nan Yang,  Lili Zhao,  Gernot Frenking,  Zhong-Ming Sun|2025|Nature Chemistry|17|556|doi:10.1038/s41557-025-01765-4
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2m9z64
title: CCDC 2422656: Experimental Crystal Structure Determination

description: Related Article: Yumeng Song, Yifan Zhou, Congcong Chen, Kezhou Fan, Zhen Wang, Yu Guo, Ziming Chen, Lingling Mao, Jun Yin, Philip C. Y. Chow|2025|J.Am.Chem.Soc.|147|19902|doi:10.1021/jacs.5c04417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25307
title: solution structure of SATB1 homeodomain
DOI: 10.5517/ccdc.csd.cc2mxkrw
title: CCDC 2440529: Experimental Crystal Structure Determination

description: Related Article: Ricarda Zimmermann, Nicolas Montesdeoca, Johannes Karges|2025|J.Med.Chem.|68|12258|doi:10.1021/acs.jmedchem.5c01124
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25308
title: Chemical shift assignments of human obscurin Ig58
DOI: 10.5517/ccdc.csd.cc2n4kt6
title: CCDC 2447258: Experimental Crystal Structure Determination

description: Related Article: Shengzhong Li, Xiao-Li Zhao, Xueliang Shi, Hai-Bo Yang|2025|J.Am.Chem.Soc.|147|34498|doi:10.1021/jacs.5c08506
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n4mgx
title: CCDC 2447309: Experimental Crystal Structure Determination

description: Related Article: Shengzhong Li, Xiao-Li Zhao, Xueliang Shi, Hai-Bo Yang|2025|J.Am.Chem.Soc.|147|34498|doi:10.1021/jacs.5c08506
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n4mhy
title: CCDC 2447310: Experimental Crystal Structure Determination

description: Related Article: Shengzhong Li, Xiao-Li Zhao, Xueliang Shi, Hai-Bo Yang|2025|J.Am.Chem.Soc.|147|34498|doi:10.1021/jacs.5c08506
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n4mk0
title: CCDC 2447312: Experimental Crystal Structure Determination

description: Related Article: Shengzhong Li, Xiao-Li Zhao, Xueliang Shi, Hai-Bo Yang|2025|J.Am.Chem.Soc.|147|34498|doi:10.1021/jacs.5c08506
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25309
title: FBP28 WW2 , mutation Y438R
DOI: 10.5517/ccdc.csd.cc2n7f7l
title: CCDC 2449999: Experimental Crystal Structure Determination

description: Related Article: Jun Wang, Ruihong Yao, Yanli Li, Zhihao Lu, Bin Yang, Zhou Wu, Yong Li, Jiajia Zeng, Zhirong Geng, Zhilin Wang|2025|J.Hazard.Mater.|499||doi:10.1016/j.jhazmat.2025.140233
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25310
title: FBP28 WW2 mutant Y446L
DOI: 10.13018/bmr25311
title: FBP28 WW2 mutant W457F
DOI: 10.13018/bmr25312
title: SOLUTION STRUCTURE OF HUMAN MBD1 CXXC1 DOMAIN
DOI: 10.5517/ccdc.csd.cc2q1q4n
title: CCDC 2504091: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Zhong‐Wen Chen, Teng‐Yu Huang, Xu‐Dong Wang, Yu‐Fei Ao, Qi‐Qiang Wang, De‐Xian Wang|2026|Eur.J.Org.Chem.|29|e202501180|doi:10.1002/ejoc.202501180
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2q1q8s
title: CCDC 2504095: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Zhong‐Wen Chen, Teng‐Yu Huang, Xu‐Dong Wang, Yu‐Fei Ao, Qi‐Qiang Wang, De‐Xian Wang|2026|Eur.J.Org.Chem.|29|e202501180|doi:10.1002/ejoc.202501180
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25313
title: FBP28 WW2 mutant Y438R DNDC
DOI: 10.5517/ccdc.csd.cc2q1qcw
title: CCDC 2504098: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Zhong‐Wen Chen, Teng‐Yu Huang, Xu‐Dong Wang, Yu‐Fei Ao, Qi‐Qiang Wang, De‐Xian Wang|2026|Eur.J.Org.Chem.|29|e202501180|doi:10.1002/ejoc.202501180
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2q1qdx
title: CCDC 2504099: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Zhong‐Wen Chen, Teng‐Yu Huang, Xu‐Dong Wang, Yu‐Fei Ao, Qi‐Qiang Wang, De‐Xian Wang|2026|Eur.J.Org.Chem.|29|e202501180|doi:10.1002/ejoc.202501180
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25314
title: FBP28 WW2 mutant Y238R L453A DNDC
DOI: 10.5517/ccdc.csd.cc2q1qj1
title: CCDC 2504103: Experimental Crystal Structure Determination

description: Related Article: Jun Zhu, Zhong‐Wen Chen, Teng‐Yu Huang, Xu‐Dong Wang, Yu‐Fei Ao, Qi‐Qiang Wang, De‐Xian Wang|2026|Eur.J.Org.Chem.|29|e202501180|doi:10.1002/ejoc.202501180
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13018/bmr25315
title: FBP28 WW2 mutant Y438R DN