cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60645/bdc-b7d9-81mg
title: Atherosclerosis Risk in Communities (ARIC) Cohort

description: 
The Atherosclerosis Risk in Communities (ARIC) Study, sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. The four communities are Forsyth County, NC; Jackson, MS; the northwest suburbs of Minneapolis, MN; and Washington County, MD. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date.

ARIC includes two parts: the Cohort Component and the Community Surveillance Component. The Cohort Component began in 1987, and each ARIC field center randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive examination, including medical, social, and demographic data. These participants were examined with the baseline visit occurring in 1987-89, the second visit in 1990-92, the third visit in 1993-95, the fourth visit in 1996-98, the fifth visit in 2011-13, the sixth visit 2016-17 and the seventh visit 2018-19. Follow-up occurs yearly by telephone to maintain contact with participants and to assess health status of the cohort. 

In the Community Surveillance Component, these four communities were investigated to determine the community-wide occurrence of hospitalized myocardial infarction and coronary heart disease deaths in men and women aged 35-84 years. Hospitalized stroke is investigated in cohort participants only. Starting in 2006, the study conducted community surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) for heart failure events beginning in 2005. Community Surveillance for non-cohorts ended in event year 2014.

ARIC is currently funded through 2028.

**The ARIC Cohort is utilized in the following dbGaP sub-studies.** To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" section of this top-level study page [phs000280](study.cgi?study_id=phs000280) ARIC Cohort. 
 - [phs000557](study.cgi?study_id=phs000557) ARIC_CARe - [phs000090](study.cgi?study_id=phs000090) GENEVA_ARIC - [phs000223](study.cgi?study_id=phs000223) PAGE_CALiCo_ARIC - [phs000398](study.cgi?study_id=phs000398) GO-ESP: HeartGo_ARIC - [phs000668](study.cgi?study_id=phs000668) CHARGE_ARIC - [phs000860](study.cgi?study_id=phs000860) MICORTEX - [phs001536](study.cgi?study_id=phs001536) CCDG_ARIC
DOI: 10.5281/zenodo.18505043
title: Do adult survival and productivity explain northward density shifts in European songbirds?
DOI: 10.5281/zenodo.18505042
title: Do adult survival and productivity explain northward density shifts in European songbirds?
DOI: 10.60645/bdc-077d-90xm
title: CARDIA Cohort

description: 
CARDIA is a study examining the etiology and natural history of cardiovascular disease beginning in young adulthood. In 1985-1986, a cohort of 5115 healthy black and white men and women aged 18-30 years were selected to have approximately the same number of people in subgroups of age (18-24 and 25-30), sex, race, and education (high school or less and more than high school) within each of four US Field Centers. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), 2005-2006 (Year 20), and 2010-2011 (Year 25); the proportions of the surviving cohort that have returned for the seven follow-up examinations were 90%, 86%, 81%, 79%, 74%, 72%, and 72%, respectively. In addition to the follow-up examinations, participants are contacted regularly for the ascertainment of information on out-patient procedures and hospitalizations experienced between contacts. Within the past five years, 95% of the original surviving cohort has been contacted.

While the specifics of each examination has differed somewhat, data have been collected on a variety of factors believed to be related to heart disease. These include conditions with clear links to heart disease such as blood pressure, cholesterol and other lipids. Data have also been collected on physical measurements such as weight and skinfold fat as well as lifestyle factors such as substance use (tobacco and alcohol), dietary and exercise patterns, behavioral and psychological variables, medical and family history, and other chemistries (e.g., insulin and glucose). In addition, subclinical atherosclerosis was measured via echocardiography during Years 5, 10, and 25, computed tomography during Years 15 and 20, and carotid ultrasound during Year 20.

**The CARDIA Cohort is utilized in the following dbGaP sub-studies.** To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page [phs000285](study.cgi?study_id=phs000285) CARDIA Cohort.  - [phs000236](study.cgi?study_id=phs000236) PAGE_CALiCo_CARDIA - [phs000309](study.cgi?study_id=phs000309) GENEVA_CARDIA - [phs000399](study.cgi?study_id=phs000399) GO-ESP HeartGO_CARDIA - [phs000613](study.cgi?study_id=phs000613) CARDIA_CARe
DOI: 10.60645/bdc-3inw-33m4
title: CARDIA Cohort

description: 
CARDIA is a study examining the etiology and natural history of cardiovascular disease beginning in young adulthood. In 1985-1986, a cohort of 5115 healthy black and white men and women aged 18-30 years were selected to have approximately the same number of people in subgroups of age (18-24 and 25-30), sex, race, and education (high school or less and more than high school) within each of four US Field Centers. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), 2005-2006 (Year 20), and 2010-2011 (Year 25); the proportions of the surviving cohort that have returned for the seven follow-up examinations were 90%, 86%, 81%, 79%, 74%, 72%, and 72%, respectively. In addition to the follow-up examinations, participants are contacted regularly for the ascertainment of information on out-patient procedures and hospitalizations experienced between contacts. Within the past five years, 95% of the original surviving cohort has been contacted.

While the specifics of each examination has differed somewhat, data have been collected on a variety of factors believed to be related to heart disease. These include conditions with clear links to heart disease such as blood pressure, cholesterol and other lipids. Data have also been collected on physical measurements such as weight and skinfold fat as well as lifestyle factors such as substance use (tobacco and alcohol), dietary and exercise patterns, behavioral and psychological variables, medical and family history, and other chemistries (e.g., insulin and glucose). In addition, subclinical atherosclerosis was measured via echocardiography during Years 5, 10, and 25, computed tomography during Years 15 and 20, and carotid ultrasound during Year 20.

**The CARDIA Cohort is utilized in the following dbGaP sub-studies.** To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page [phs000285](study.cgi?study_id=phs000285) CARDIA Cohort.  - [phs000236](study.cgi?study_id=phs000236) PAGE_CALiCo_CARDIA - [phs000309](study.cgi?study_id=phs000309) GENEVA_CARDIA - [phs000399](study.cgi?study_id=phs000399) GO-ESP HeartGO_CARDIA - [phs000613](study.cgi?study_id=phs000613) CARDIA_CARe
DOI: 10.60645/bdc-b2k7-927x
title: Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older

description: 
The Cardiovascular Health Study (CHS) is a prospective study of risk factors for development and progression of CHD and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 


Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 


Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication and mortality.

The Cardiovascular Health Study Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" section of this top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older.
DOI: 10.60645/bdc-0223-9i5o
title: Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older

description: 
The Cardiovascular Health Study (CHS) is a prospective study of risk factors for development and progression of CHD and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 


Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 


Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication and mortality.

The Cardiovascular Health Study Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" section of this top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older.
DOI: 10.60645/bdc-neh1-3def
title: Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older

description: 
The Cardiovascular Health Study (CHS) is a prospective study of risk factors for development and progression of CHD and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 


Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 


Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication and mortality.

The Cardiovascular Health Study Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" section of this top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older.
DOI: 10.25504/fairsharing.17a17e
title: FAIRsharing record for: FAIR Metric - Metadata uses CESSDA Access Rights Vocabulary
title: FM_Gen2-MI-A1.2_M_CARV

description: This FAIRsharing record describes:  Checks whether the data access terms in the metadata belong to the CESSDA Access Rights controlled vocabulary.
description: The source of this description is the metadata record on FAIRsharing.org, an educational and informative resource that describes and links databases, standards, and data policies. FAIRsharing also creates collections of these resources and recommendations of databases and standards based on 3rd party data policies.
DOI: 10.60645/bdc-85s2-m323
title: Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older

description: 
The Cardiovascular Health Study (CHS) is a prospective study of risk factors for development and progression of CHD and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 


Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 


Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication and mortality.

The Cardiovascular Health Study Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" section of this top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older.
DOI: 10.25504/fairsharing.022caa
title: FAIRsharing record for: FAIR Metric - Metadata Uses CESSDA ELSST Keywords
title: FM_I2_M_CEK

description: This FAIRsharing record describes:  Checks whether keywords used in the metadata belong to the ELSST controlled vocabulary.
description: The source of this description is the metadata record on FAIRsharing.org, an educational and informative resource that describes and links databases, standards, and data policies. FAIRsharing also creates collections of these resources and recommendations of databases and standards based on 3rd party data policies.
DOI: 10.25504/fairsharing.195ab2
title: FAIRsharing record for: FAIR Metric - Metadata Uses CESSDA Topic Vocabulary
title: FM_Gen2-MI-I2A_M_CTV

description: This FAIRsharing record describes:  Checks whether metadata topics belong to the controlled vocabulary called CESSDA Topic Classification.
description: The source of this description is the metadata record on FAIRsharing.org, an educational and informative resource that describes and links databases, standards, and data policies. FAIRsharing also creates collections of these resources and recommendations of databases and standards based on 3rd party data policies.
DOI: 10.60645/bdc-zpas-bl0p
title: NHLBI GO-ESP: Lung Cohorts Exome Sequencing Project (Pulmonary Arterial Hypertension)

description: 
The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery  Act investment,    was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with    heart, lung and blood diseases.  These and related diseases that are of high impact to public health and individuals from    diverse racial and ethnic groups will be studied.  These data may help researchers understand the causes of disease,    contributing to better ways to prevent, diagnose, and treat diseases, as well as determine whether to tailor prevention    and treatments to specific populations.  This could lead to more effective treatments and reduce the likelihood of side effects.     GO-ESP is comprised of five collaborative components: 3 cohort consortia - HeartGO, LungGO, and WHISP - and 2 sequencing centers -    BroadGO and SeattleGO.

The syndrome of pulmonary hypertension (PH) is a pulmonary disease that carries very high morbidity and mortality.  Pulmonary \tarterial hypertension (PAH) is a category of PH (WHO Group 1) that includes several entities (idiopathic or heritable PAH, and PAH associated \twith other diseases such as connective tissue diseases including scleroderma-associated PAH) and carries a dismal prognosis, in particular \twhen it relates to scleroderma-associated PAH (median survival of about 4 years). It is believed that the severity of structural changes \tinvolving the pulmonary vasculature and right ventricular failure are genetically determined.  The &#39;Genomics and Genetics of \tPulmonary Arterial Hypertension&#39; study at Johns Hopkins University aims to identify genetic determinants associated with risk \tof PAH in a cohort of European American and African American participants with and without PAH.  The study also focuses on patients \twith scleroderma, who are further stratified according to those who have or do not have PAH.  The broad goals of the \tLung GO/ESP-GO falls into two general categories: (i) discovery of all variants (i.e., common and rare) in all protein-coding \tregions of the human genome (i.e., the exome) conferring risk to complex pulmonary diseases including PAH.  The Johns Hopkins \tUniversity PAH cohort offers a unique opportunity to elucidate genetic variants that cause PAH.
DOI: 10.25504/fairsharing.236b80
title: FAIRsharing record for: FAIR Metric - Metadata Uses DDI Analysis Unit Vocabulary
title: FM_Gen2-MI-I2A_M_DAUV

description: This FAIRsharing record describes:  Checks if certain information elements contain terms from the DDI Analysis Unit controlled vocabulary.
description: The source of this description is the metadata record on FAIRsharing.org, an educational and informative resource that describes and links databases, standards, and data policies. FAIRsharing also creates collections of these resources and recommendations of databases and standards based on 3rd party data policies.
DOI: 10.25504/fairsharing.71b621
title: FAIRsharing record for: FAIR Metric - Metadata Uses DDI Mode Of Collection Vocabulary
title: FM_Gen2-MI-I2A_M_DMOCV

description: This FAIRsharing record describes:  Checks if certain information elements contain terms from the DDI Mode of Collection controlled vocabulary.
description: The source of this description is the metadata record on FAIRsharing.org, an educational and informative resource that describes and links databases, standards, and data policies. FAIRsharing also creates collections of these resources and recommendations of databases and standards based on 3rd party data policies.
DOI: 10.25504/fairsharing.15baa8
title: FAIRsharing record for: FAIR Metric - Metadata Uses DDI Time Method Vocabulary
title: FM_Gen2-MI-I2A_M_DTMV

description: This FAIRsharing record describes:  Checks if certain information elements contain terms from the DDI Time Method controlled vocabulary.
description: The source of this description is the metadata record on FAIRsharing.org, an educational and informative resource that describes and links databases, standards, and data policies. FAIRsharing also creates collections of these resources and recommendations of databases and standards based on 3rd party data policies.