cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7951478.v1
title: gVCF_NA21127

description: 1000 Genomes gVCF mapped to hs37d5 for NA21127. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951436
title: gVCF_NA21126

description: 1000 Genomes gVCF mapped to hs37d5 for NA21126. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951436.v1
title: gVCF_NA21126

description: 1000 Genomes gVCF mapped to hs37d5 for NA21126. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951415
title: Global maps of Biodiversity Intactness Index (Sanchez-Ortiz et al., 2019 - bioRxiv )

description: Global maps of biodiversity intactness for the year 2005 (abundance-based BII and richness-based BII). These high-resolution rasters were used to plot Figure 1 in "Land-use and related pressures have reduced biotic integrity more on islands than on mainlands" (Sanchez-Ortiz et al., 2019). We have updated methods previously used to estimate BII globally (Newbold et al., 2016) to allow pressure effects to differ between islands and mainlands, while also implementing some other recent improvements in modelling.
DOI: 10.6084/m9.figshare.12879125.v1
title: Additional file 4 of High throughput nano-liter RT-qPCR to classify soil contamination using a soil arthropod

description: Additional file 4:Details of the qPCR assays used in this study; primer sequences and efficiencies; associated GO terms (XLS 42 KB)
DOI: 10.6084/m9.figshare.7951403
title: supplements.docx

description: Multi-variate regression analyses of metabolic traits in CAH patients.
DOI: 10.6084/m9.figshare.7951409
title: gVCF_NA21125

description: 1000 Genomes gVCF mapped to hs37d5 for NA21125. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12879143.v6
title: Additional file of High throughput nano-liter RT-qPCR to classify soil contamination using a soil arthropod

description: Additional file of High throughput nano-liter RT-qPCR to classify soil contamination using a soil arthropod
DOI: 10.6084/m9.figshare.7951403.v1
title: supplements.docx

description: Multi-variate regression analyses of metabolic traits in CAH patients.
DOI: 10.6084/m9.figshare.7951409.v1
title: gVCF_NA21125

description: 1000 Genomes gVCF mapped to hs37d5 for NA21125. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12879125
title: Additional file 4 of High throughput nano-liter RT-qPCR to classify soil contamination using a soil arthropod

description: Additional file 4:Details of the qPCR assays used in this study; primer sequences and efficiencies; associated GO terms (XLS 42 KB)
DOI: 10.6084/m9.figshare.7951364
title: gVCF_NA21124

description: 1000 Genomes gVCF mapped to hs37d5 for NA21124. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951340
title: gVCF_NA21122

description: 1000 Genomes gVCF mapped to hs37d5 for NA21122. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951352
title: gVCF_NA21123

description: 1000 Genomes gVCF mapped to hs37d5 for NA21123. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951352.v1
title: gVCF_NA21123

description: 1000 Genomes gVCF mapped to hs37d5 for NA21123. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951364.v1
title: gVCF_NA21124

description: 1000 Genomes gVCF mapped to hs37d5 for NA21124. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951340.v1
title: gVCF_NA21122

description: 1000 Genomes gVCF mapped to hs37d5 for NA21122. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951325
title: gVCF_NA21120

description: 1000 Genomes gVCF mapped to hs37d5 for NA21120. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951325.v1
title: gVCF_NA21120

description: 1000 Genomes gVCF mapped to hs37d5 for NA21120. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951295
title: Supplementary Material for: Genotype-Phenotype Correlation in Long-Term Cohort of Japanese Patients with Moyamoya Disease

description: <b><i>Background:</i></b> Homozygosity of this p.R4810K founder variant of <i>RNF213</i> moyamoya disease (MMD) susceptibility gene is known to influence the severity of the clinical disease phenotype at disease onset. However, the association between this genotype and long-term clinical manifestations has remained unclear. <b><i>Objectives:</i></b> The principal goal of this study was to investigate whether and how the p.R4810K variant of <i>RNF213</i> influences the long-term phenotype in Japanese patients with MMD. <b><i>Method:</i></b> This retrospective cohort study included 94 Japanese patients with MMD who underwent direct or combined bypass for revascularization with the p.R4810K genotype determined in our hospital. The following phenotypic parameters were analyzed at disease onset and over a long-term period: age and initial presentation at onset, recurrent stroke after initial revascularization, and final modified Rankin Scale. <b><i>Results:</i></b> The p.R4810K genotype was significantly associated with the phenotype at onset, especially in younger patients. Over a median follow-up period of 100 months, recurrent stroke occurred in 6 out of 94 patients: none out of 5 patients with the homozygous variant, 5 out of 64 with the heterozygous variant, and 1 out of 25 in the wild-type group. There were no significant differences among the genotypes. In particular, recurrent cerebral hemorrhage occurred in 5 patients, all possessing the heterozygous variant. The log-rank test showed no difference between the genotypes in the stroke-free survival rate. Furthermore, the p.R4810K genotype was not associated with a poor functional condition. <b><i>Conclusions:</i></b> The p.R4810K founder variant of <i>RNF213</i> affects the phenotype at disease onset. However, the optimal revascularization may be effective, regardless of the genotype, even for the homozygous variant, which has been thought to be the most pathogenic. This genotype may not strongly influence the long-term clinical manifestations or poor prognosis in MMD.
DOI: 10.6084/m9.figshare.7951313
title: gVCF_NA21119

description: 1000 Genomes gVCF mapped to hs37d5 for NA21119. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951295.v1
title: Supplementary Material for: Genotype-Phenotype Correlation in Long-Term Cohort of Japanese Patients with Moyamoya Disease

description: <b><i>Background:</i></b> Homozygosity of this p.R4810K founder variant of <i>RNF213</i> moyamoya disease (MMD) susceptibility gene is known to influence the severity of the clinical disease phenotype at disease onset. However, the association between this genotype and long-term clinical manifestations has remained unclear. <b><i>Objectives:</i></b> The principal goal of this study was to investigate whether and how the p.R4810K variant of <i>RNF213</i> influences the long-term phenotype in Japanese patients with MMD. <b><i>Method:</i></b> This retrospective cohort study included 94 Japanese patients with MMD who underwent direct or combined bypass for revascularization with the p.R4810K genotype determined in our hospital. The following phenotypic parameters were analyzed at disease onset and over a long-term period: age and initial presentation at onset, recurrent stroke after initial revascularization, and final modified Rankin Scale. <b><i>Results:</i></b> The p.R4810K genotype was significantly associated with the phenotype at onset, especially in younger patients. Over a median follow-up period of 100 months, recurrent stroke occurred in 6 out of 94 patients: none out of 5 patients with the homozygous variant, 5 out of 64 with the heterozygous variant, and 1 out of 25 in the wild-type group. There were no significant differences among the genotypes. In particular, recurrent cerebral hemorrhage occurred in 5 patients, all possessing the heterozygous variant. The log-rank test showed no difference between the genotypes in the stroke-free survival rate. Furthermore, the p.R4810K genotype was not associated with a poor functional condition. <b><i>Conclusions:</i></b> The p.R4810K founder variant of <i>RNF213</i> affects the phenotype at disease onset. However, the optimal revascularization may be effective, regardless of the genotype, even for the homozygous variant, which has been thought to be the most pathogenic. This genotype may not strongly influence the long-term clinical manifestations or poor prognosis in MMD.
DOI: 10.6084/m9.figshare.7951313.v1
title: gVCF_NA21119

description: 1000 Genomes gVCF mapped to hs37d5 for NA21119. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12879146.v2
title: Additional file of QTL mapping in white spruce: gene maps and genomic regions underlying adaptive traits across pedigrees, years and environments

description: Additional file of QTL mapping in white spruce: gene maps and genomic regions underlying adaptive traits across pedigrees, years and environments
DOI: 10.6084/m9.figshare.7951289
title: Additional materials from The history, genome and biology of NCTC 30: a non-pandemic <i>Vibrio cholerae</i> isolate from World War One

description: The sixth global cholera pandemic lasted from 1899 to 1923. However, despite widespread fear of the disease and of its negative effects on troop morale, very few soldiers in the British Expeditionary Forces contracted cholera between 1914 and 1918. Here, we have revived and sequenced the genome of NCTC 30, a 102-year-old <i>Vibrio cholerae</i> isolate, which we believe is the oldest publicly available live <i>V. cholerae</i> strain in existence. NCTC 30 was isolated in 1916 from a British soldier convalescent in Egypt. We found that this strain does not encode cholera toxin, thought to be necessary to cause cholera, and is not part of <i>V. cholerae</i> lineages responsible for the pandemic disease. We also show that NCTC 30, which predates the introduction of penicillin-based antibiotics, harbours a functional β-lactamase antibiotic resistance gene. Our data corroborate and provide molecular explanations for previous phenotypic studies of NCTC 30 and provide a new high-quality genome sequence for historical, non-pandemic <i>V. cholerae</i>.
DOI: 10.6084/m9.figshare.7951289.v1
title: Additional materials from The history, genome and biology of NCTC 30: a non-pandemic <i>Vibrio cholerae</i> isolate from World War One

description: The sixth global cholera pandemic lasted from 1899 to 1923. However, despite widespread fear of the disease and of its negative effects on troop morale, very few soldiers in the British Expeditionary Forces contracted cholera between 1914 and 1918. Here, we have revived and sequenced the genome of NCTC 30, a 102-year-old <i>Vibrio cholerae</i> isolate, which we believe is the oldest publicly available live <i>V. cholerae</i> strain in existence. NCTC 30 was isolated in 1916 from a British soldier convalescent in Egypt. We found that this strain does not encode cholera toxin, thought to be necessary to cause cholera, and is not part of <i>V. cholerae</i> lineages responsible for the pandemic disease. We also show that NCTC 30, which predates the introduction of penicillin-based antibiotics, harbours a functional β-lactamase antibiotic resistance gene. Our data corroborate and provide molecular explanations for previous phenotypic studies of NCTC 30 and provide a new high-quality genome sequence for historical, non-pandemic <i>V. cholerae</i>.
DOI: 10.6084/m9.figshare.7951256
title: gVCF_NA21117

description: 1000 Genomes gVCF mapped to hs37d5 for NA21117. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951274
title: gVCF_NA21118

description: 1000 Genomes gVCF mapped to hs37d5 for NA21118. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951247
title: gVCF_NA21116

description: 1000 Genomes gVCF mapped to hs37d5 for NA21116. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951274.v1
title: gVCF_NA21118

description: 1000 Genomes gVCF mapped to hs37d5 for NA21118. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951247.v1
title: gVCF_NA21116

description: 1000 Genomes gVCF mapped to hs37d5 for NA21116. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951256.v1
title: gVCF_NA21117

description: 1000 Genomes gVCF mapped to hs37d5 for NA21117. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951241
title: gVCF_NA21115

description: 1000 Genomes gVCF mapped to hs37d5 for NA21115. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951235
title: gVCF_NA21114

description: 1000 Genomes gVCF mapped to hs37d5 for NA21114. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951241.v1
title: gVCF_NA21115

description: 1000 Genomes gVCF mapped to hs37d5 for NA21115. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951232
title: Supplementary Material for: Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits

description: <b><i>Background:</i></b> Hypertension is a major risk factor for atherosclerotic disease. However, it is still not clear whether mechanical stress caused by hypertension directly affects the atherosclerotic development in the aorta and coronary arteries. <b><i>Objectives and Methods:</i></b> We generated a hypertensive (HTN) rabbit model by surgical removal of the left kidney and partial ligation of the right renal artery. After a 16-week cholesterol diet, we compared aortic and coronary atherosclerosis of HTN rabbits with those of normotensive rabbits. <b><i>Results:</i></b> Hypertension did not affect lipid and apolipoprotein levels in plasma but led to a 3.0-fold increase in aortic atherosclerosis and a 1.7-fold increase in coronary atherosclerosis compared with control rabbits. Enhanced atherosclerosis in HTN rabbits was caused by significant increases in macrophages and smooth muscle cells in the lesions. Furthermore, oxidized LDL contents in the lesions were significantly increased in HTN rabbits. In addition, HTN rabbits exhibited prominent hyaline arteriolosclerosis in coronary arterioles. <b><i>Conclusions:</i></b> These results indicate that hyper tension not only enhances atherosclerosis in large arteries including the aorta and coronary arteries but also affects hyaline arteriolosclerosis in small arteries.
DOI: 10.6084/m9.figshare.7951235.v1
title: gVCF_NA21114

description: 1000 Genomes gVCF mapped to hs37d5 for NA21114. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.12879152
title: Additional file 1 of QTL mapping in white spruce: gene maps and genomic regions underlying adaptive traits across pedigrees, years and environments

description: Additional file 1:List of gene markers retained for linkage map construction. List of primer sequences used for PCR amplification for each gene-marker retained for the construction of individual linkage maps for both crosses P and D. (XLS 6 MB)
DOI: 10.6084/m9.figshare.12879152.v1
title: Additional file 1 of QTL mapping in white spruce: gene maps and genomic regions underlying adaptive traits across pedigrees, years and environments

description: Additional file 1:List of gene markers retained for linkage map construction. List of primer sequences used for PCR amplification for each gene-marker retained for the construction of individual linkage maps for both crosses P and D. (XLS 6 MB)
DOI: 10.6084/m9.figshare.7951232.v1
title: Supplementary Material for: Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits

description: <b><i>Background:</i></b> Hypertension is a major risk factor for atherosclerotic disease. However, it is still not clear whether mechanical stress caused by hypertension directly affects the atherosclerotic development in the aorta and coronary arteries. <b><i>Objectives and Methods:</i></b> We generated a hypertensive (HTN) rabbit model by surgical removal of the left kidney and partial ligation of the right renal artery. After a 16-week cholesterol diet, we compared aortic and coronary atherosclerosis of HTN rabbits with those of normotensive rabbits. <b><i>Results:</i></b> Hypertension did not affect lipid and apolipoprotein levels in plasma but led to a 3.0-fold increase in aortic atherosclerosis and a 1.7-fold increase in coronary atherosclerosis compared with control rabbits. Enhanced atherosclerosis in HTN rabbits was caused by significant increases in macrophages and smooth muscle cells in the lesions. Furthermore, oxidized LDL contents in the lesions were significantly increased in HTN rabbits. In addition, HTN rabbits exhibited prominent hyaline arteriolosclerosis in coronary arterioles. <b><i>Conclusions:</i></b> These results indicate that hyper tension not only enhances atherosclerosis in large arteries including the aorta and coronary arteries but also affects hyaline arteriolosclerosis in small arteries.
DOI: 10.6084/m9.figshare.7951199
title: gVCF_NA21112

description: 1000 Genomes gVCF mapped to hs37d5 for NA21112. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951205
title: gVCF_NA21113

description: 1000 Genomes gVCF mapped to hs37d5 for NA21113. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951199.v1
title: gVCF_NA21112

description: 1000 Genomes gVCF mapped to hs37d5 for NA21112. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951178
title: gVCF_NA21110

description: 1000 Genomes gVCF mapped to hs37d5 for NA21110. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951190
title: gVCF_NA21111

description: 1000 Genomes gVCF mapped to hs37d5 for NA21111. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951172
title: gVCF_NA21109

description: 1000 Genomes gVCF mapped to hs37d5 for NA21109. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951178.v1
title: gVCF_NA21110

description: 1000 Genomes gVCF mapped to hs37d5 for NA21110. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951190.v1
title: gVCF_NA21111

description: 1000 Genomes gVCF mapped to hs37d5 for NA21111. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951166
title: Trees

description: Individual trees location (Pinus pinea L. and Pinus pinaster Ait.) in mixed Mediterranean stands.
DOI: 10.6084/m9.figshare.7951172.v1
title: gVCF_NA21109

description: 1000 Genomes gVCF mapped to hs37d5 for NA21109. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951160
title: gVCF_NA21108

description: 1000 Genomes gVCF mapped to hs37d5 for NA21108. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7951157
title: Supplementary Material for: Risk Factors for Late-Onset Sepsis in Preterm Infants: A Multicenter Case-Control Study

description: <b><i>Background:</i></b> Late-onset sepsis (LOS) in preterm infants is a leading cause of mortality and morbidity. Timely recognition and initiation of antibiotics are important factors for improved outcomes. Identification of risk factors could allow selection of infants at an increased risk for LOS. <b><i>Objectives:</i></b> The aim was to identify risk factors for LOS. <b><i>Methods:</i></b> In this multicenter case-control study, preterm infants born at ≤30 weeks of gestation were included at 9 neonatal intensive care units. Detailed demographical and clinical data were collected daily up to day 28 postnatally. Clinical and demographic risk factors were identified using univariate and multivariate regression analyses in a 1: 1 matched case-control cohort. <b><i>Results:</i></b> In total, 755 infants were included, including 194 LOS cases (41 gram-negative cases, 152 gram-positive cases, and 1 fungus). In the case-control cohort, every additional day of parenteral feeding increased the risk for LOS (adjusted OR = 1.29; 95% CI 1.07–1.55; <i>p</i> = 0.006), whereas antibiotics administration decreased this risk (OR = 0.08; 95% CI 0.01–0.88; <i>p</i> = 0.039). These findings could largely be attributed to specific LOS-causative pathogens, since these predictive factors could be identified for gram-positive, but not for gram-negative, LOS cases. Specifically cephalosporins administration prior to clinical onset was inversely related to coagulase-negative staphylococcus LOS (CoNS-LOS) development. Formula feeding was an independent risk factor for development of CoNS-LOS (OR = 3.779; 95% CI 1.257–11.363; <i>p</i> = 0.018). <b><i>Conclusion:</i></b> The length of parenteral feeding was associated with LOS, whereas breastmilk administration was protective against CoNS-LOS. A rapid advancement of enteral feeding, preferably with breastmilk, may proportionally reduce the number of parenteral feeding days and consequently the risk for LOS.
DOI: 10.6084/m9.figshare.7951181.v1
title: Krause et al. (2019) Earth's Future

description: Output is from three dynamic vegetation models (LPJ-GUESS, LPJ and CABLE) driven by three combinations of climate change and land-use change scenarios (SSP1xRCP26, SSP3xRCP60, SSP5xRCP85). The output also includes simulations in which either land use or climate and CO2 were kept constant from 2014 on to isolate the effects of future land-use change and climate change. Output variables are total carbon pools, evapotranspiration, surface albedo and runoff for four different time periods (2015,2050,2070,2090, 20-year averages). Spatial resolution is 0.5° (LPJ-GUESS and LPJ) or 1° (CABLE).<br>
DOI: 10.6084/m9.figshare.7951154
title: Supplementary Material for: Supporting the Management of Patients with Heart Failure within Asia-Pacific, Middle East, and African Countries: A Toolbox for Healthcare Providers

description: <b><i>Objectives:</i></b> The management of heart failure (HF) is most effective when established treatment guidelines and recommendations are followed. We aimed to develop a “Toolbox” of resources to facilitate the care of patients with acute HF and chronic HF with reduced ejection fraction delivered by healthcare professionals across Asia-Pacific, the Middle East and Africa (henceforth referred to as the “Region”). <b><i>Methods:</i></b> We convened a group of cardiologists from across the Region to develop a set of checklists, algorithms, and other practical resources. These resources are based on our experiences, current evidence, and international guidelines. <b><i>Results:</i></b> The HF Toolbox comprises three simplified sets of resources for use in the Emergency Room (ER), hospital and outpatient settings. Resources include admission and discharge checklists, treatment algorithms, recommendations for forming a multidisciplinary team, patient education, and self-management materials, and key performance indicators to monitor whether standards of care are met or maintained, or should be improved. <b><i>Conclusions:</i></b> The HF Toolbox provides practical resources to simplify the management of patients with HF and to support the formation of HF programs in the Region. The Toolbox is aligned with current guideline recommendations and can support the management of patients from presentation in the ER, through hospital admission to outpatient care.
DOI: 10.6084/m9.figshare.7951160.v1
title: gVCF_NA21108

description: 1000 Genomes gVCF mapped to hs37d5 for NA21108. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307