cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3695391.v1
title: Supplementary Material for: Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer

description: Cancer immunotherapy is becoming a cornerstone in the clinical care of cancer patients due to the breakthrough trials with immune checkpoint blockade antibodies and chimeric antigen receptor T cells. The next breakthrough in cancer immunotherapy is likely to be oncolytic viruses engineered to selectively kill tumor cells and deceive the immune system to believe that the tumor is a foreign entity that needs to be eradicated. We have developed AdVince, an oncolytic adenovirus for treatment of liver metastases from neuroendocrine tumor (NET). AdVince includes the gene promoter from human chromogranin A for selective replication in neuroendocrine cells, miR122 target sequences for reduced liver toxicity, and a cell-penetrating peptide in the capsid for increased infectivity of tumor cells and optimized spread within tumors. This paper describes the preclinical evaluation of AdVince on freshly isolated human gastrointestinal NET cells resected from liver metastases and freshly isolated human hepatocytes as well as in fresh human blood. AdVince selectively replicates in and kills NET cells. Approximately 73-fold higher concentration of AdVince is needed to induce a similar level of cytotoxicity in NET cells as in hepatocytes. AdVince did not activate complement or induce considerable amount of proinflammatory cytokines or chemokines in human blood. The data presented herein indicate that AdVince can be safely evaluated in a phase I/IIa clinical trial for patients with liver-dominant NET.
DOI: 10.6084/m9.figshare.3695136
title: Supplementary Material for: Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis

description: <b><i>Background:</i></b> Nintedanib is approved for the treatment of idiopathic pulmonary fibrosis (IPF) and has been shown to slow disease progression by reducing annual lung function decline. <b><i>Objective:</i></b> To evaluate the results of a large cohort of IPF patients treated with nintedanib within a compassionate use program (CUP) in Germany (9 centers). <b><i>Methods:</i></b> Patients (≥40 years) were required to have a confirmed diagnosis of IPF, a forced vital capacity (FVC) ≥50% predicted (pred.) and a carbon monoxide diffusing capacity (DLCO) 30-79% pred. and not to be eligible for pirfenidone treatment. Clinical data, pulmonary function tests and adverse events were recorded up to July 2015. <b><i>Results:</i></b> Sixty-two patients (48 male/14 female) with moderate IPF (FVC 64 ± 17% pred. and DLCO 40 ± 10% pred.) were treated with nintedanib. 77% of patients switched from pirfenidone (mean treatment duration 14 ± 2 months) mostly due to disease progression (mean decline in FVC 7.4 ± 3% pred. in the 6 months prior to nintedanib intake). Initiation of nintedanib treatment occurred 69 ± 29 months after IPF diagnosis, and mean treatment duration was 8 ± 4 months. Most patients (63%) stabilized 6 months after treatment start (mean FVC decline 3 ± 1 vs. -17 ± 2% in patients with disease progression; p &lt; 0.01). The most common adverse events were diarrhea (63%) and weight loss (50%). Dose reduction occurred in 34% of cases and treatment discontinuation in 10%. <b><i>Conclusion:</i></b> Nintedanib treatment was generally well tolerated and was associated with FVC stabilization in the majority of IPF patients in this CUP setting where most patients were not treatment naïve. Our data are in agreement with the previously published data.
DOI: 10.6084/m9.figshare.3694968
title: Phylogenetic trees

description: Phylogenetic trees generated with starBEAST (*BEAST). clade tree = Potos_sp_run1.treecytochrome b tree = Potos_all_run1.tree<br>Phylogenetic trees generated with phyml:rooted tree: Potos_phyml_rooted.treeunrooted tree: Potos_phyml_rooted.tree
DOI: 10.6084/m9.figshare.3694770
title: Supplementary Material for: Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice

description: Helminths induce type 2 immune responses and establish an anti-inflammatory milieu in their hosts. This immunomodulation was previously shown to improve diet-induced insulin resistance which is linked to chronic inflammation. In the current study, we demonstrate that infection with the filarial nematode <i>Litomosoides sigmodontis</i> increased the eosinophil number and alternatively activated macrophage abundance within epididymal adipose tissue (EAT) and improved glucose tolerance in diet-induced obese mice in an eosinophil-dependent manner. <i>L. sigmodontis</i> antigen (LsAg) administration neither altered the body weight of animals nor adipose tissue mass or adipocyte size, but it triggered type 2 immune responses, eosinophils, alternatively activated macrophages, and type 2 innate lymphoid cells in EAT. Improvement in glucose tolerance by LsAg treatment remained even in the absence of Foxp3+ regulatory T cells. Furthermore, PCR array results revealed that LsAg treatment reduced inflammatory immune responses and increased the expression of genes related to insulin signaling (<i>Glut4</i>, <i>Pde3b, Pik3r1</i>, and<i> Hk2</i>) and fatty acid uptake (<i>Fabp4</i> and <i>Lpl</i>). Our investigation demonstrates that <i>L. sigmodontis </i>infection and LsAg administration reduce diet-induced EAT inflammation and improve glucose tolerance. Helminth-derived products may, therefore, offer new options to improve insulin sensitivity, while loss of helminth infections in developing and developed countries may contribute to the recent increase in the prevalence of type 2 diabetes.
DOI: 10.6084/m9.figshare.3694422
title: Supplementary Material for: From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century

description: <b><i>Objective: </i></b>The global obesity epidemic continues, new approaches are needed to understand the causes. We analyzed data from an evolutionary perspective, stressing developmental plasticity. <b><i>Methods: </i></b>We present diachronical height, weight, and BMI data for 702,902 Swiss male conscripts aged 18-20 years, a representative, standardized and unchanged data source. <b><i>Results: </i></b>From 1875 to 1879, the height distribution was slightly left-skewed; 12.1% of the conscripts were underweight, overweight and obesity were rare. The BMI-to-height relationship was positive but not linear, and very short conscripts were particularly slim. Since the 1870s, Swiss conscripts became taller, a trend that markedly slowed in the 1990s. In contrast, weight increased in two distinct steps at the end of the 1980s and again after 2002. Since 2010, BMI did not increase but stabilized at a high level. <b><i>Conclusions: </i></b>The body of young men adapted differently to varying living conditions over time: First, less investment in height and weight under conditions of undernutrition and food uncertainty; second, more investment in height under more stable nutritional conditions; third, development of obesity during conditions of plateaued height growth, overnutrition, and decreasing physical activity. This example contributes to the evaluation of hypotheses on human developmental plasticity.
DOI: 10.6084/m9.figshare.3694422.v1
title: Supplementary Material for: From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century

description: <b><i>Objective: </i></b>The global obesity epidemic continues, new approaches are needed to understand the causes. We analyzed data from an evolutionary perspective, stressing developmental plasticity. <b><i>Methods: </i></b>We present diachronical height, weight, and BMI data for 702,902 Swiss male conscripts aged 18-20 years, a representative, standardized and unchanged data source. <b><i>Results: </i></b>From 1875 to 1879, the height distribution was slightly left-skewed; 12.1% of the conscripts were underweight, overweight and obesity were rare. The BMI-to-height relationship was positive but not linear, and very short conscripts were particularly slim. Since the 1870s, Swiss conscripts became taller, a trend that markedly slowed in the 1990s. In contrast, weight increased in two distinct steps at the end of the 1980s and again after 2002. Since 2010, BMI did not increase but stabilized at a high level. <b><i>Conclusions: </i></b>The body of young men adapted differently to varying living conditions over time: First, less investment in height and weight under conditions of undernutrition and food uncertainty; second, more investment in height under more stable nutritional conditions; third, development of obesity during conditions of plateaued height growth, overnutrition, and decreasing physical activity. This example contributes to the evaluation of hypotheses on human developmental plasticity.
DOI: 10.6084/m9.figshare.3692187
title: Modelling population density over time: how spatial distance matters

description: Modelling population density over time: how spatial distance matters. <i>Regional Studies</i>. This study provides an empirical application of the Bayesian approach for modelling the evolution of population density distribution across time. It focuses on the case of Massachusetts by tracking changes in the importance of spatial distance from Boston concerning citizens’ choices of residence according to data for 1880–90 and 1930–2010. By adopting a Bayesian strategy, results show that Boston reinforced its attractiveness until the 1960s, when the city's accessibility no longer represented the unique determinant of population density distribution. Referring to selected historical evidence, a few possible interpretations are presented to endorse these results.
DOI: 10.6084/m9.figshare.3692187.v1
title: Modelling population density over time: how spatial distance matters

description: Modelling population density over time: how spatial distance matters. <i>Regional Studies</i>. This study provides an empirical application of the Bayesian approach for modelling the evolution of population density distribution across time. It focuses on the case of Massachusetts by tracking changes in the importance of spatial distance from Boston concerning citizens’ choices of residence according to data for 1880–90 and 1930–2010. By adopting a Bayesian strategy, results show that Boston reinforced its attractiveness until the 1960s, when the city's accessibility no longer represented the unique determinant of population density distribution. Referring to selected historical evidence, a few possible interpretations are presented to endorse these results.
DOI: 10.6084/m9.figshare.3692139.v1
title: Distribution of Industrial Growth in Nagoya Metropolitan Area, Japan: An Exploratory Analysis Using Geographical and Technological Proximities

description: Yamada E. and Kawakami T. Distribution of industrial growth in Nagoya Metropolitan Area, Japan: an exploratory analysis using geographical and technological proximities, <i>Regional Studies</i>. This study explores the spatial pattern of industry dynamics in Japan's motor metropolis of Nagoya. Exploratory spatial data analysis methodologies that reflect aspects of both geographical and technological proximities within regional industries are proposed and applied to the long-term, sustained manufacturing and service sector growth rates. The descriptive results identify the presence of positive multilayered growth clusters, driven mainly by the automobile and associated industries. These growth clusters differ in sectoral composition and geographical scale; the larger specialized growth cluster of transportation equipment encompasses the smaller one composed of diverse manufacturing and service sectors.
DOI: 10.21223/n6ttqa/mzjeeu
title: bkDzp5LRp8AI2LGT6s88g4YnCAO0T6.docx
DOI: 10.21223/n6ttqa/y7u9ya
title: Paratrioza_project.rar
DOI: 10.21223/n6ttqa/3rags6
title: 11634_DataDictionary_ElementDescription.tab
DOI: 10.21223/n6ttqa/suemt0
title: 11634_DataDictionary_UniqueIdentifier.tab
DOI: 10.21223/n6ttqa/bsixuk
title: 11634_DataDictionary_ElementDescription.tab
DOI: 10.21223/n6ttqa/ys8znr
title: 11634_DataDictionary_UniqueIdentifier.tab
DOI: 10.21223/n6ttqa/7ipd30
title: 11634_DataDictionary_ElementDescription.tab
DOI: 10.21223/n6ttqa
title: Dataset for: Phenology model and risk maps of the potato psyllid Bactericera cockerelli

description: The new data set of Bactericera cockerelli is necessary to develop the process-based temperature-driven and age-stage structured phenology models, and then to apply these models to insect species distribution and risk mapping. This phenology contains outputs in 2 modules: Modeling (Development time, Mortality, etc.) and Simulation (constant, fluctuating and spatial).
DOI: 10.6084/m9.figshare.3690456
title: Brazil: accelerated metropolization and urban crisis

description: Migration and rapid demographic growth in large metropolitan areas in Brazil are associated with high levels of territorial and social inequality. Four indicators of an associated urban crisis are examined: inequality in housing conditions, per capita income and years of schooling; a poor (or lack of a) public transport system, urban congestion and traffic accidents; high levels of violence and murder and the rapid diffusion of diseases linked to the lack of sanitary facilities. Territorial guidelines for a more balanced polycentric urban network and an active urban policy are required to address these issues but face a lack of political will.
DOI: 10.6084/m9.figshare.3690456.v1
title: Brazil: accelerated metropolization and urban crisis

description: Migration and rapid demographic growth in large metropolitan areas in Brazil are associated with high levels of territorial and social inequality. Four indicators of an associated urban crisis are examined: inequality in housing conditions, per capita income and years of schooling; a poor (or lack of a) public transport system, urban congestion and traffic accidents; high levels of violence and murder and the rapid diffusion of diseases linked to the lack of sanitary facilities. Territorial guidelines for a more balanced polycentric urban network and an active urban policy are required to address these issues but face a lack of political will.
DOI: 10.5281/zenodo.4013938
title: Snow depth and land surface cover in Tuolumne basin (California) from Pléiades images

description: This dataset contains products calculated from Pléiades images. Details about the products are available in https://doi.org/10.5194/tc-2020-15. These products were used in Figure 4. - pleiades_elevation_difference_raw_winter_minus_summer.tif : raw difference of digital elevation models (DEMs) calculated from Pléiades stereo images. - pleiades_snow_depth_winter.tif : difference of DEMs on snow terrain only (where pleiades_land_surface_cover_winter.tif==1 with morphological erosion) - pleiades_land_surface_cover_winter.tif : land cover surface in the winter images (1= snow, 2=forest, 3= stable terrain, 4=water) - pleiades_land_surface_cover_summer.tif : land cover surface in the summer images (1= snow, 2=forest, 3= stable terrain, 4=water) - elevation_difference_style.qml : qgis style used for elevation difference and snow depth. - land_surface_cover_style.qml : qgis style used for land cover surface.
DOI: 10.6084/m9.figshare.3689142
title: A Tale of Two Regionalisms: Improving the Measurement of Regionalism in Australia and Beyond

description: Brown A. J. and Deem J. A tale of two regionalisms: improving the measurement of regionalism in Australia and beyond, <i>Regional Studies</i>. Studies of regional identification are integral to the role of regionalism in political development, but how does one study regionalism when subnational political scales and regional political culture may be out of alignment? This question is tackled using Australia, a federation theorized as having possibly hit a regionalization ‘ceiling effect’, but which empirical study using a moderate relational approach shows to have not one regionalism but two within its political culture: formal ‘state-regionalism’ reflected in its federal system and a more organic ‘region-regionalism’ only thinly reflected in political structure, albeit apparently still consistent with federalism. Both are identified as politically salient and reflected in institutional preferences, but as also reinforcing debates that regionalization from a devolutionary perspective is far from complete, as manifested in citizen support for new regional government. The results better inform reform debates and provide departure points for research.
DOI: 10.6084/m9.figshare.3688599
title: A Bayesian Approach to Parameter Estimation in the Presence of Spatial Missing Data

description: The missing data problem has been widely addressed in the literature. The traditional methods for handling missing data may be not suited to spatial data, which can exhibit distinctive structures of dependence and/or heterogeneity. As a possible solution to the spatial missing data problem, this paper proposes an approach that combines the Bayesian Interpolation method [Benedetti, R. & Palma, D. (1994) Markov random field-based image subsampling method, <i>Journal of Applied Statistics</i>, 21(5), 495–509] with a multiple imputation procedure. The method is developed in a univariate and a multivariate framework, and its performance is evaluated through an empirical illustration based on data related to labour productivity in European regions.
DOI: 10.6084/m9.figshare.3688599.v1
title: A Bayesian Approach to Parameter Estimation in the Presence of Spatial Missing Data

description: The missing data problem has been widely addressed in the literature. The traditional methods for handling missing data may be not suited to spatial data, which can exhibit distinctive structures of dependence and/or heterogeneity. As a possible solution to the spatial missing data problem, this paper proposes an approach that combines the Bayesian Interpolation method [Benedetti, R. & Palma, D. (1994) Markov random field-based image subsampling method, <i>Journal of Applied Statistics</i>, 21(5), 495–509] with a multiple imputation procedure. The method is developed in a univariate and a multivariate framework, and its performance is evaluated through an empirical illustration based on data related to labour productivity in European regions.
DOI: 10.6084/m9.figshare.3688587
title: Cultural Diversity and Cultural Distance as Choice Determinants of Migration Destination

description: This study analyses the impact of cultural composition on regional attractiveness from the perspective of international migrant sorting behaviour on a European regional NUTS1 level. We use an attitudinal survey to quantify cultural distances between natives and immigrants in the region concerned, and estimate the migrants’ varying preferences for both cultural diversity and cultural distance. To account for regional unobserved heterogeneity, our econometric analysis employs artificial instrumental variables, as developed by Bayer et al., [2004a. An equilibrium model of sorting in an urban housing market. <i>NBER</i> no. 10865]. The main conclusions are twofold. On the one hand, cultural diversity increases regional attractiveness. On the other hand, average cultural distance greatly weakens regional attractiveness.
DOI: 10.6084/m9.figshare.3688587.v1
title: Cultural Diversity and Cultural Distance as Choice Determinants of Migration Destination

description: This study analyses the impact of cultural composition on regional attractiveness from the perspective of international migrant sorting behaviour on a European regional NUTS1 level. We use an attitudinal survey to quantify cultural distances between natives and immigrants in the region concerned, and estimate the migrants’ varying preferences for both cultural diversity and cultural distance. To account for regional unobserved heterogeneity, our econometric analysis employs artificial instrumental variables, as developed by Bayer et al., [2004a. An equilibrium model of sorting in an urban housing market. <i>NBER</i> no. 10865]. The main conclusions are twofold. On the one hand, cultural diversity increases regional attractiveness. On the other hand, average cultural distance greatly weakens regional attractiveness.
DOI: 10.6084/m9.figshare.3683793.v1
title: Rich transcription: verbal, nonverbal and performance behaviours in studio-based instrumental learning

description: The paper describes the research methods used to investigate studio interactions in higher education music, through the analysis of a range of interpersonal behaviours, cross-referenced with interview data.
DOI: 10.6084/m9.figshare.3682134
title: A high accuracy diffusion kinetics formalism for random multicomponent alloys: application to high entropy alloys

description: In this paper, a new, lighter, version of the highly accurate Moleko, Allnatt and Allnatt formalism for describing both tracer (self) and collective diffusion kinetics in multicomponent random alloys is presented. Verification of the resulting expressions is performed by means of kinetic Monte Carlo simulation. The accuracy of the new formalism is much higher than that of the combined Manning and Holdsworth and Elliott formalism discussed recently. Using this formalism the possible range of the tracer diffusion ratio of the highest to the lowest atomic component is examined for equiatomic (or near equiatomic) binary, ternary, quaternary and quinary alloys. It is shown that in the random alloy model, the correlation effect is the highest with a reduction of the fastest tracer diffusion by 40–55%, when moving from two pure metals to their equiatomic binary alloy. By adding the third component (with an intermediate mobility) this effect can be further increased with a possible total reduction of the fastest tracer diffusion by up to 70% (depending on the combinations of mobilities), while adding the fourth component brings this reduction up to 80% and with a possible maximum of up to 85% reduction for the 5-component alloy (again depending on the combinations of mobilities). But the slowest diffusing components are not affected by this. This suggests that kinetics arguments alone are not enough for explaining the sluggish diffusion observed of all atomic components in (equiatomic) high-entropy alloys.