cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/wgb2kxd2nc
title: Excessive-Dose Baricitinib for Severe Alopecia Areata Unresponsive to Conventional Therapy: A Real-World Assessment

description: 1. Research Hypothesis:
Our study hypothesized that a higher-than-approved dose of baricitinib (6 mg daily) would demonstrate enhanced efficacy in promoting hair regrowth for patients with severe, treatment-refractory alopecia areata (AA), while maintaining an acceptable safety profile under close monitoring.
2. What the Data Shows & Notable Findings:
The shared dataset comprises deidentified clinical data from four female patients with severe AA (including alopecia universalis and totalis) who were unresponsive to conventional therapies. The data shows that:
Efficacy: Dose escalation to baricitinib 6 mg daily resulted in clinically meaningful hair regrowth (SALT score improvement) in 3 out of 4 patients (75%). One patient achieved complete regrowth (SALT 0).
Safety: The data captures the safety profile, showing transient and manageable laboratory abnormalities (e.g., mild anemia, thrombocytosis, elevated creatinine) in some patients, with no severe adverse events reported.
Key Finding: The data supports the concept that a dose-dependent response exists for baricitinib in AA, and 6 mg may overcome the therapeutic "ceiling" of the standard 4 mg dose for some refractory patients.
3. How the Data Was Gathered:
Data was collected retrospectively from electronic medical records at our institution. It includes:
Baseline characteristics: Age, disease duration, AA subtype, baseline SALT score.
Treatment history: Prior and concomitant therapies, baricitinib dosing modifications.
Longitudinal efficacy outcomes: Serial SALT scores recorded at clinical visits.
Safety monitoring: Serial results of standard laboratory tests (complete blood count, comprehensive metabolic panel).
All data was anonymized to protect patient privacy.
4. How to Interpret and Use the Data:
This dataset is primarily intended for validation of our reported findings and for secondary analysis, such as exploring trends in dose-response relationships or safety parameters in severe AA.
Users should note the inherent limitations of a small, retrospective case series. The findings are hypothesis-generating and require confirmation in larger, controlled studies.
DOI: 10.17632/wgb2kxd2nc.1
title: Excessive-Dose Baricitinib for Severe Alopecia Areata Unresponsive to Conventional Therapy: A Real-World Assessment

description: 1. Research Hypothesis:
Our study hypothesized that a higher-than-approved dose of baricitinib (6 mg daily) would demonstrate enhanced efficacy in promoting hair regrowth for patients with severe, treatment-refractory alopecia areata (AA), while maintaining an acceptable safety profile under close monitoring.
2. What the Data Shows & Notable Findings:
The shared dataset comprises deidentified clinical data from four female patients with severe AA (including alopecia universalis and totalis) who were unresponsive to conventional therapies. The data shows that:
Efficacy: Dose escalation to baricitinib 6 mg daily resulted in clinically meaningful hair regrowth (SALT score improvement) in 3 out of 4 patients (75%). One patient achieved complete regrowth (SALT 0).
Safety: The data captures the safety profile, showing transient and manageable laboratory abnormalities (e.g., mild anemia, thrombocytosis, elevated creatinine) in some patients, with no severe adverse events reported.
Key Finding: The data supports the concept that a dose-dependent response exists for baricitinib in AA, and 6 mg may overcome the therapeutic "ceiling" of the standard 4 mg dose for some refractory patients.
3. How the Data Was Gathered:
Data was collected retrospectively from electronic medical records at our institution. It includes:
Baseline characteristics: Age, disease duration, AA subtype, baseline SALT score.
Treatment history: Prior and concomitant therapies, baricitinib dosing modifications.
Longitudinal efficacy outcomes: Serial SALT scores recorded at clinical visits.
Safety monitoring: Serial results of standard laboratory tests (complete blood count, comprehensive metabolic panel).
All data was anonymized to protect patient privacy.
4. How to Interpret and Use the Data:
This dataset is primarily intended for validation of our reported findings and for secondary analysis, such as exploring trends in dose-response relationships or safety parameters in severe AA.
Users should note the inherent limitations of a small, retrospective case series. The findings are hypothesis-generating and require confirmation in larger, controlled studies.
DOI: 10.17632/xc3mtsbjtg
title: When wood-based thermal mass performs as well as concrete

description: Data for "When wood-based thermal mass performs as well as concrete" (awaiting publication). A full-scale experiment conducted to validate a theoretical approach for optimizing the distribution of internal thermal mass in concert with natural buoyancy ventilation. The ventilation is driven by the indoor temperature damping (which is produced by the thermal mass) and flows up during the night and down during the day. Two test buildings were constructed in Alabama, USA (ASHRAE climate zone 3A), to compare the performance of wood and concrete thermal mass in this temperature-ventilation cycle.

A first experiment was conducted from October 8 to November 8, 2022, in which one test building was fitted with concrete thermal mass panels, while the second didn't have internal thermal mass and served as a control. Another comparative experiment was conducted a year later, between October 8 and November 8, 2023, in which wood thermal mass panels were installed on the walls, floor, and ceiling of the empty test building, allowing a direct comparison with the concrete thermal mass in the other building. The sensor layout remained identical in both test buildings and across both experiments. A pair of ATMOS 22 ultrasonic anemometers measured the flow velocity and direction in the two pairs of ventilation chimneys, along with Apogee EE08-SS air probes to measure temperature and relative humidity. Three Apogee ST-110-SS thermistors measured the air temperature in the middle of the interior spaces at equidistant heights between the floor and ceiling. Hukseflux HFP04 foil heat flux and surface temperature sensors were installed on the back and front faces of the middle wall thermal mass panels, or directly on the exposed wall insulation in the empty control building. In the first experiment, two additional heat flux sensors were installed on the exposed floor and ceiling insulation of the building with concrete thermal mass and the empty control building. In the second experiment, those same sensors were moved to the exposed surface of the wood floor and ceiling thermal mass panels. Outside the test buildings, a Gill Maximet weather station monitored the ambient air temperature and relative humidity along with the wind speed, gust, and direction. A pair of Apogee SL-510-SS Pyrgeometer and SP-110-SS Pyrgeometer also measured incoming solar and infrared irradiance. All outdoor measurements were taken at roof level, in between the two test buildings.
DOI: 10.17632/xc3mtsbjtg.1
title: When wood-based thermal mass performs as well as concrete

description: Data for "When wood-based thermal mass performs as well as concrete" (awaiting publication). A full-scale experiment conducted to validate a theoretical approach for optimizing the distribution of internal thermal mass in concert with natural buoyancy ventilation. The ventilation is driven by the indoor temperature damping (which is produced by the thermal mass) and flows up during the night and down during the day. Two test buildings were constructed in Alabama, USA (ASHRAE climate zone 3A), to compare the performance of wood and concrete thermal mass in this temperature-ventilation cycle.

A first experiment was conducted from October 8 to November 8, 2022, in which one test building was fitted with concrete thermal mass panels, while the second didn't have internal thermal mass and served as a control. Another comparative experiment was conducted a year later, between October 8 and November 8, 2023, in which wood thermal mass panels were installed on the walls, floor, and ceiling of the empty test building, allowing a direct comparison with the concrete thermal mass in the other building. The sensor layout remained identical in both test buildings and across both experiments. A pair of ATMOS 22 ultrasonic anemometers measured the flow velocity and direction in the two pairs of ventilation chimneys, along with Apogee EE08-SS air probes to measure temperature and relative humidity. Three Apogee ST-110-SS thermistors measured the air temperature in the middle of the interior spaces at equidistant heights between the floor and ceiling. Hukseflux HFP04 foil heat flux and surface temperature sensors were installed on the back and front faces of the middle wall thermal mass panels, or directly on the exposed wall insulation in the empty control building. In the first experiment, two additional heat flux sensors were installed on the exposed floor and ceiling insulation of the building with concrete thermal mass and the empty control building. In the second experiment, those same sensors were moved to the exposed surface of the wood floor and ceiling thermal mass panels. Outside the test buildings, a Gill Maximet weather station monitored the ambient air temperature and relative humidity along with the wind speed, gust, and direction. A pair of Apogee SL-510-SS Pyrgeometer and SP-110-SS Pyrgeometer also measured incoming solar and infrared irradiance. All outdoor measurements were taken at roof level, in between the two test buildings.
DOI: 10.6084/m9.figshare.29503922.v3
title: Materials for Ice Age Megafauna Dispersal manuscript

description: <b>Video S1. Simulated mean annual temperature (MAT)</b> <b>across the Eurasian continent</b><b>Video S2. Simulated mean annual precipitation (MAP) across the Eurasian continent</b><b>Video S3. Simulated biome distribution across the Eurasian continen</b><b>t</b><b>Data S1. </b><b>Summary of measured carbonate stable and clumped isotope data</b><b>Data S2. X-ray diffraction (XRD) of the carbonate samples</b><b>Data S3. Details of dual clumped isotope data</b><b>Data S4. Details of estimated water stable isotope data</b><b>Data S5. Existing palynological records in Central Asia compared with climate simulations</b>
DOI: 10.17632/d4c4z6dk2z
title: Hato (2017) storm tide characters and responses to morphological evolution

description: This data set include the numerical model simulated storm tide characters of Typhoon Hato (2017) in the 'Bay-Inlet-Channel' system of the Pearl River Estuary, China. The storm tide model was validated by recorded water levels during Hato at five tidal stations. The parameters presented here are the maximum storm tide (MXST), factors' (storm surge, astronomical tide, river flood, and factors' nonlinear interactions) contribution to the MXST, the astronomical tidal range, and the time lag between astronomical tide and storm tide. The responses of the storm tide to morphological evolution were simulated, with two scenarios of before ('Pre-EP' under 1960s geomorphology) and after ('Post-EP' under 2020s geomorphology) large-scale engineering projects, and the Post-EP case represents the validated actual Hato event. In addition, a potential 'Triple Coincidence' disaster was simulated, by adjusting the timing of a flood peak 5 days before Hato to be superimposed on the actual coincidence of peak surge and spring high tide during Hato, exhibiting even higher MXSTs.
DOI: 10.17632/d4c4z6dk2z.1
title: Hato (2017) storm tide characters and responses to morphological evolution

description: This data set include the numerical model simulated storm tide characters of Typhoon Hato (2017) in the 'Bay-Inlet-Channel' system of the Pearl River Estuary, China. The storm tide model was validated by recorded water levels during Hato at five tidal stations. The parameters presented here are the maximum storm tide (MXST), factors' (storm surge, astronomical tide, river flood, and factors' nonlinear interactions) contribution to the MXST, the astronomical tidal range, and the time lag between astronomical tide and storm tide. The responses of the storm tide to morphological evolution were simulated, with two scenarios of before ('Pre-EP' under 1960s geomorphology) and after ('Post-EP' under 2020s geomorphology) large-scale engineering projects, and the Post-EP case represents the validated actual Hato event. In addition, a potential 'Triple Coincidence' disaster was simulated, by adjusting the timing of a flood peak 5 days before Hato to be superimposed on the actual coincidence of peak surge and spring high tide during Hato, exhibiting even higher MXSTs.
DOI: 10.15468/dl.nzyvf4
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Chama croceata",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 12 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008442-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vtvxjr
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris minor",
 "Country is Libya",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008443-250914085247600/datasets/export for details.
DOI: 10.17632/t9c3gsysn8.1
title: Microneedling-Assisted Delivery of Type-III and Type-XVII Collagen for Refractory Androgenetic Alopecia: A Pilot Study on Therapeutic Efficacy

description: Supplementary Figure 1: A 51-year-old male with a 12-year history of androgenetic alopecia (AGA) underwent microneedling treatment with type III collagen (COL3) and type XVII collagen (COL17). Following 12 weeks of treatment, repigmentation of previously gray hair was observed, and newly grown hair exhibited pigmentation. Newly pigmented hairs are indicated within the dashed circles. (Scale bar = 2 mm.) 
Supplementary Figure 2: A 53-year-old male with a 5-year history of androgenetic alopecia (AGA) underwent a 24-week course of microneedling treatment with type III collagen (COL3) and type XVII collagen (COL17). Pre-treatment and post-treatment high-frequency ultrasound images demonstrate an increase in both superficial dermal (SD) and deep dermal (DD) thickness, with no apparent change in the epidermal layer (E). (Scale bar = 1 mm.)
Supplementary Table 1: Baseline characteristics of patients with refractory AGA.
DOI: 10.15468/dl.4c4ta3
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris minor",
 "Country is Lithuania",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008444-250914085247600/datasets/export for details.
DOI: 10.15468/dl.sufgfm
title: Occurrence Download

description: A dataset containing 263 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Phalaris minor",
 "Country is Mexico",
 "HasCoordinate is true"
 ]
}

 The dataset includes 263 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008445-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/pzfjt7nf33
title: Polyethylene Degradation by Electrochemical Oxidation Using a Nb/BDD Anode: Characterization of Products via Pyrolysis Coupled to GC-MS

description: Chromatograms obtained via Py-GC-MS, model Frontier Lab pyrolyzer (Koriyama, Japan) coupled with a GC-MSQP2010 Shimadzu gas chromatograph (Kyoto, Japan). For this purpose, 20 µL of the sample was deposited in a crucible and dried in an oven at 60 °C for 2 hours. Pyrolysis was conducted in an inert atmosphere at a temperature of 750 °C for 0.2 minutes. The pyrolysis products were immediately introduced into the gas chromatography system equipped with an RTX-5MS capillary column (30 m, 0.25 mm ID, 0.25 µm film thickness, with a 10 m guard column). The GC temperature program was set to start at 40 °C for 5 minutes, followed by a ramp of 18 °C/min to 330 °C, which was then held for 14 minutes. Detection was carried out using mass spectrometry in full scan mode for the MP fragmentation pattern and selected ion monitoring (SIM) method for the treatment samples, selecting the ions m/z 41, 43, 55, 56, 66, 69, 78, 83, 97, and 111 for quantification. Operational conditions were standardized, using helium as the carrier gas at a constant flow rate of 1.2 mL/min.
For the polyethylene pattern, the measurement were performed in a full scan method to correctly identify the retention time of each compound. To obtain complementary information about the results and how they were used, please find the paper published with the same title as this database.
DOI: 10.17632/pzfjt7nf33.1
title: Polyethylene Degradation by Electrochemical Oxidation Using a Nb/BDD Anode: Characterization of Products via Pyrolysis Coupled to GC-MS

description: Chromatograms obtained via Py-GC-MS, model Frontier Lab pyrolyzer (Koriyama, Japan) coupled with a GC-MSQP2010 Shimadzu gas chromatograph (Kyoto, Japan). For this purpose, 20 µL of the sample was deposited in a crucible and dried in an oven at 60 °C for 2 hours. Pyrolysis was conducted in an inert atmosphere at a temperature of 750 °C for 0.2 minutes. The pyrolysis products were immediately introduced into the gas chromatography system equipped with an RTX-5MS capillary column (30 m, 0.25 mm ID, 0.25 µm film thickness, with a 10 m guard column). The GC temperature program was set to start at 40 °C for 5 minutes, followed by a ramp of 18 °C/min to 330 °C, which was then held for 14 minutes. Detection was carried out using mass spectrometry in full scan mode for the MP fragmentation pattern and selected ion monitoring (SIM) method for the treatment samples, selecting the ions m/z 41, 43, 55, 56, 66, 69, 78, 83, 97, and 111 for quantification. Operational conditions were standardized, using helium as the carrier gas at a constant flow rate of 1.2 mL/min.
For the polyethylene pattern, the measurement were performed in a full scan method to correctly identify the retention time of each compound. To obtain complementary information about the results and how they were used, please find the paper published with the same title as this database.
DOI: 10.17632/8sx2ddz6xb
title: BRD3 Proteomics

description: BRD3-interacting proteins were isolated by immunoprecipitation using a BRD3-specific antibody from LPS-treated THP1-M155 and RAW264.7 cells. Equal volumes of immunoprecipitates from each sample were resolved on 4–12% Criterion XT Bis-Tris gels (Bio-Rad, Cat. #3450124), followed by mass spectrometry analysis.
DOI: 10.17632/8sx2ddz6xb.1
title: BRD3 Proteomics

description: BRD3-interacting proteins were isolated by immunoprecipitation using a BRD3-specific antibody from LPS-treated THP1-M155 and RAW264.7 cells. Equal volumes of immunoprecipitates from each sample were resolved on 4–12% Criterion XT Bis-Tris gels (Bio-Rad, Cat. #3450124), followed by mass spectrometry analysis.
DOI: 10.17632/9xf92fry3v
title: The relationships between insomnia, physical health, loneliness, and life satisfaction within a biopsychosocial model of well-being

description: The cross-sectional survey study comprised 511 undergraduate students from several universities in Saudi Arabia, including 72.60% women. Most of the students were between 18 and 23 years old (90.02%), studying the health track (70.06%), with the majority being in their second year of studies (31.51%), which is commonly referred to as the first year of specialty after the preparatory year. The data were collected online between April and September 2024. The survey included standardized psychological questionnaires: the General Self-Rated Health (GSRH-2), Satisfaction With Life Scale (SWLS-5), UCLA Loneliness Scale (ULS-8), and Athens Insomnia Scale (AIS-8). The study examines gender differences in all variables and associations between loneliness, insomnia, physical health, and life satisfaction. The study hypothesized that insomnia and physical health mediate the relationship between loneliness and life satisfaction.
DOI: 10.17632/9xf92fry3v.1
title: The relationships between insomnia, physical health, loneliness, and life satisfaction within a biopsychosocial model of well-being

description: The cross-sectional survey study comprised 511 undergraduate students from several universities in Saudi Arabia, including 72.60% women. Most of the students were between 18 and 23 years old (90.02%), studying the health track (70.06%), with the majority being in their second year of studies (31.51%), which is commonly referred to as the first year of specialty after the preparatory year. The data were collected online between April and September 2024. The survey included standardized psychological questionnaires: the General Self-Rated Health (GSRH-2), Satisfaction With Life Scale (SWLS-5), UCLA Loneliness Scale (ULS-8), and Athens Insomnia Scale (AIS-8). The study examines gender differences in all variables and associations between loneliness, insomnia, physical health, and life satisfaction. The study hypothesized that insomnia and physical health mediate the relationship between loneliness and life satisfaction.
DOI: 10.17632/hz9b97pc96
title: Estudo das barreiras à adoção da construção off-site no Brasil - dados coletados

description: Dados coletados com base em questionário
DOI: 10.17632/hz9b97pc96.1
title: Estudo das barreiras à adoção da construção off-site no Brasil - dados coletados

description: Dados coletados com base em questionário
DOI: 10.17632/gbc8czckgj
title: F, Cl, and H2O in nominally anhydrous minerals and hydrous minerals from lithospheric mantle xenoliths

description: These datasets include nominally anhydrous mineral (NAM; clinopyroxene, orthopyroxene, and olivine) major and minor element compositions, as well as F, Cl, and H2O concentrations in NAMs and F and Cl concentrations in hydrous minerals. Samples analyzed are peridotite xenoliths of the North American sub-continental lithospheric mantle (SCLM) from the Navajo Volcanic Field (NVF) and Cerro Chato on the Colorado Plateau and Elephant Butte and Kilbourne Hole along the southern Rio Grande Rift, as well as one peridotite xenolith from O'ahu, Hawaii. Previous studies have suggested that the North American SCLM has been metasomatized by fluids derived from the subducted Farallon plate. In the modally hydrated NVF xenoliths, hydrous minerals contain the vast majority of water and halogens. Pyroxenes in these xenoliths are F-poor but variably enriched in H2O and Cl, suggesting metasomatism via a hydrous fluid. Additionally, samples with anomalously high water contents have variations in Cl content across the grains that resemble diffusion profiles but do not have such variations in H2O or F. This suggests recent volatile enrichment leading to Cl heterogeneity in a subset of samples. 

In the modally anhydrous xenoliths, F is enriched in the NAMs and correlates with indices of melt depletion, whereas Cl is depleted and does not correlate with indices of melt depletion or metasomatism.