cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27063501
title: Is combined letrozole and clomiphene superior to either as monotherapy: a systemic review and meta-analysis based on clinical trials

description: This research was conducted to assess the therapeutic advantage of combined letrozole and clomiphene citrate versus monotherapy for polycystic ovarian syndrome (PCOS) patients. Five databases were searched using the search string: (letrozole and clomiphene) AND (clomiphene OR clomiphene citrate OR CC) AND (letrozole OR LE) AND (ovulation induc* OR fertility induc* OR fertility preserv*) AND (polycystic ovarian syndrome OR PCOS). All statistical analyses were conducted in Review Manager 5.4.1. Random effect-effect model was used to pool risk ratio (RR), mean difference (MD), and odds ratio (OR) and their corresponding 95% confidence interval (CI). Moreover, qualitative analysis was conducted to qualitatively analyze ovulation, secondary outcomes, and cycle characteristics. One clinical trial and three randomized clinical trials (RCTs) were used in the study. Two studies were used in a quantitative analysis showing that combination was superior for ovulation induction (RR = 1.86 [1.37, 2.53]; <i>p</i> &lt; 0.0001; <i>I</i><sup>2</sup> = 0%), but the number of follicles ≥15 mm was significantly associated with the combination (MD = 0.40[0.14, 0.66]; <i>p</i> = 0.002; <i>I</i><sup>2</sup> = 0%). On subgroup analysis, only hot flushes were significantly associated with the combination (RR = 2.67[1.12, 6.36]; <i>p</i> = 0.03; <i>I</i><sup>2</sup> = 0%). The meta-analysis of two studies reported a significantly higher ovulation rate and number of dominant follicles in the combination therapy group compared with the LE alone arm but no significant difference in pregnancy rate, endometrial thickness, and adverse events. Our study demonstrates a significant effect of the combination on ovulation induction. The combination yielded a better chance of conception and viable pregnancy. Further studies are needed to determine the live birth rate.
HighlightsCombined Letrozole and Clomiphene is superior to either of these drugs alone for ovulation induction in PCOS.Our results conclude that the combination results in better ovulation, cycle characteristics, and secondary changes.Only the incidence of hot flushes as an adverse effect is increasingly reported in combination. Combined Letrozole and Clomiphene is superior to either of these drugs alone for ovulation induction in PCOS. Our results conclude that the combination results in better ovulation, cycle characteristics, and secondary changes. Only the incidence of hot flushes as an adverse effect is increasingly reported in combination.
DOI: 10.6084/m9.figshare.25428605
title: Quantitative proteomics reveals pregnancy prognosis signature of polycystic ovary syndrome women based on machine learning

description: We aimed to screen and construct a predictive model for pregnancy loss in polycystic ovary syndrome (PCOS) patients through machine learning methods. We obtained the endometrial samples from 33 PCOS patients and 7 healthy controls at the Reproductive Center of the Second Hospital of Lanzhou University from September 2019 to September 2020. Liquid chromatography tandem mass spectrometry (LCMS/MS) was conducted to identify the differentially expressed proteins (DEPs) of the two groups. Gene Ontology (GO) as well as Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed to analyze the related pathways and functions of the DEPs. Then, we used machine learning methods to screen the feature proteins. Multivariate Cox regression analysis was also conducted to establish the prognostic models. The performance of the prognostic model was then evaluated by the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). In addition, the Bootstrap method was conducted to verify the generalization ability of the model. Finally, linear correlation analysis was performed to figure out the correlation between the feature proteins and clinical data. Four hundred and fifty DEPs in PCOS and controls were screened out, and we obtained some pathways and functions. A prognostic model for the pregnancy loss of PCOS was established, which has good discrimination and generalization ability based on two feature proteins (TIA1, COL5A1). Strong correlation between clinical data and proteins were identified to predict the reproductive outcome in PCOS. The model based on the TIA1 and COL5A1 protein could effectively predict the occurrence of pregnancy loss in PCOS patients and provide a good theoretical foundation for subsequent research.
DOI: 10.6084/m9.figshare.25428605.v1
title: Quantitative proteomics reveals pregnancy prognosis signature of polycystic ovary syndrome women based on machine learning

description: We aimed to screen and construct a predictive model for pregnancy loss in polycystic ovary syndrome (PCOS) patients through machine learning methods. We obtained the endometrial samples from 33 PCOS patients and 7 healthy controls at the Reproductive Center of the Second Hospital of Lanzhou University from September 2019 to September 2020. Liquid chromatography tandem mass spectrometry (LCMS/MS) was conducted to identify the differentially expressed proteins (DEPs) of the two groups. Gene Ontology (GO) as well as Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed to analyze the related pathways and functions of the DEPs. Then, we used machine learning methods to screen the feature proteins. Multivariate Cox regression analysis was also conducted to establish the prognostic models. The performance of the prognostic model was then evaluated by the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). In addition, the Bootstrap method was conducted to verify the generalization ability of the model. Finally, linear correlation analysis was performed to figure out the correlation between the feature proteins and clinical data. Four hundred and fifty DEPs in PCOS and controls were screened out, and we obtained some pathways and functions. A prognostic model for the pregnancy loss of PCOS was established, which has good discrimination and generalization ability based on two feature proteins (TIA1, COL5A1). Strong correlation between clinical data and proteins were identified to predict the reproductive outcome in PCOS. The model based on the TIA1 and COL5A1 protein could effectively predict the occurrence of pregnancy loss in PCOS patients and provide a good theoretical foundation for subsequent research.
DOI: 10.6084/m9.figshare.27203555
title: HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation

description: This study aims to explore the alterations of dendritic cells (DCs) subpopulations in ectopic endometrial lesions and unveil the underlying mechanisms. Patients with endometriosis (<i>n</i> = 81) and women without endometriosis (<i>n</i> = 19) were recruited in this study. Dendritic cells (DCs) in the endometrial samples were counted after immunohistochemistry staining. The proportion of myeloid DCs and plasmacytoid DCs was calculated by flow cytometry. Primary DCs were isolated from tissues, and the cell viability and apoptosis were examined by MTT assay and flow cytometry. Cytokines were detected by the enzyme-linked immunosorbent assay. Differentially expressed genes were filtered by analyzing two datasets that were downloaded from GEO database and detected by RT-qPCR in tissues and isolated DCs. The function of HSD11B1 was examined in an endometrial stromal cell-DCs co-culture system and <i>in vitro</i> cultured DCs. Reduced myeloid DCs and increased CD11c-CD304-DCs were found in ectopic endometrium compared to control endometrium and eutopic endometrium from endometriosis patients. Myeloid DCs isolated from ectopic endometrium expressed less CD80, CD83, CD86 and had reduced proliferation, increased apoptosis, and reduced cytokine production. The expression of HSD11B1 was significantly increased in both ectopic endometrium and isolated myeloid DCs. Overexpression of HSD11B1 in immature DCs could repress DCs maturation and cytokine production. Endometrial stromal cells overexpressing HSD11B1 secreted increased cortisol, which repressed DCs maturation. HSD11B1 is upregulated in ectopic endometrial lesions, which may contribute to endometriosis through repressing myeloid DCs maturation.
DOI: 10.6084/m9.figshare.26942137
title: Association between sleep quality and duration during pregnancy and risk of gestational diabetes: A systematic review and meta-analysis

description: Gestational diabetes mellitus (GDM) is associated with several adverse maternal and neonatal outcomes. Previous studies reported a link between altered sleep and risk of GDM. This systematic review aims to collate evidence on the association between impaired sleep quality and duration, and the risk of GDM. PubMed, Embase, Web of Science, and Scopus databases were searched up to January 20, 2024. Studies reporting the association between impaired sleep quality and duration and risk of GDM were included. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Random-effects meta-analysis was performed, and the results were reported as hazard ratio (HR) with 95% confidence interval (CI). 19 studies were included. Meta-analysis revealed a significant increase in the risk of GDM in pregnant women with poor sleep quality (i.e. &lt;5 PSQI) (HR: 1.50, 95% CI: 1.26 − 1.78, <i>p</i> &lt; .001). Sleep duration of &lt;7 h (HR: 1.56, 95% CI.: 1.20 − 2.01, <i>p</i> &lt; .001), and &gt;8 h (HR: 2.32, 95% CI.: 1.19 − 4.50, <i>p</i> = .01) were also associated with a significantly higher incidence of GDM. Sleep quality and duration emerge as critical risk factors of GDM. Healthcare practitioners should consider targeted interventions to improve sleep hygiene as a potential measure for GDM prevention.
DOI: 10.6084/m9.figshare.27063501.v1
title: Is combined letrozole and clomiphene superior to either as monotherapy: a systemic review and meta-analysis based on clinical trials

description: This research was conducted to assess the therapeutic advantage of combined letrozole and clomiphene citrate versus monotherapy for polycystic ovarian syndrome (PCOS) patients. Five databases were searched using the search string: (letrozole and clomiphene) AND (clomiphene OR clomiphene citrate OR CC) AND (letrozole OR LE) AND (ovulation induc* OR fertility induc* OR fertility preserv*) AND (polycystic ovarian syndrome OR PCOS). All statistical analyses were conducted in Review Manager 5.4.1. Random effect-effect model was used to pool risk ratio (RR), mean difference (MD), and odds ratio (OR) and their corresponding 95% confidence interval (CI). Moreover, qualitative analysis was conducted to qualitatively analyze ovulation, secondary outcomes, and cycle characteristics. One clinical trial and three randomized clinical trials (RCTs) were used in the study. Two studies were used in a quantitative analysis showing that combination was superior for ovulation induction (RR = 1.86 [1.37, 2.53]; <i>p</i> &lt; 0.0001; <i>I</i><sup>2</sup> = 0%), but the number of follicles ≥15 mm was significantly associated with the combination (MD = 0.40[0.14, 0.66]; <i>p</i> = 0.002; <i>I</i><sup>2</sup> = 0%). On subgroup analysis, only hot flushes were significantly associated with the combination (RR = 2.67[1.12, 6.36]; <i>p</i> = 0.03; <i>I</i><sup>2</sup> = 0%). The meta-analysis of two studies reported a significantly higher ovulation rate and number of dominant follicles in the combination therapy group compared with the LE alone arm but no significant difference in pregnancy rate, endometrial thickness, and adverse events. Our study demonstrates a significant effect of the combination on ovulation induction. The combination yielded a better chance of conception and viable pregnancy. Further studies are needed to determine the live birth rate.
HighlightsCombined Letrozole and Clomiphene is superior to either of these drugs alone for ovulation induction in PCOS.Our results conclude that the combination results in better ovulation, cycle characteristics, and secondary changes.Only the incidence of hot flushes as an adverse effect is increasingly reported in combination. Combined Letrozole and Clomiphene is superior to either of these drugs alone for ovulation induction in PCOS. Our results conclude that the combination results in better ovulation, cycle characteristics, and secondary changes. Only the incidence of hot flushes as an adverse effect is increasingly reported in combination.
DOI: 10.6084/m9.figshare.26942137.v1
title: Association between sleep quality and duration during pregnancy and risk of gestational diabetes: A systematic review and meta-analysis

description: Gestational diabetes mellitus (GDM) is associated with several adverse maternal and neonatal outcomes. Previous studies reported a link between altered sleep and risk of GDM. This systematic review aims to collate evidence on the association between impaired sleep quality and duration, and the risk of GDM. PubMed, Embase, Web of Science, and Scopus databases were searched up to January 20, 2024. Studies reporting the association between impaired sleep quality and duration and risk of GDM were included. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Random-effects meta-analysis was performed, and the results were reported as hazard ratio (HR) with 95% confidence interval (CI). 19 studies were included. Meta-analysis revealed a significant increase in the risk of GDM in pregnant women with poor sleep quality (i.e. &lt;5 PSQI) (HR: 1.50, 95% CI: 1.26 − 1.78, <i>p</i> &lt; .001). Sleep duration of &lt;7 h (HR: 1.56, 95% CI.: 1.20 − 2.01, <i>p</i> &lt; .001), and &gt;8 h (HR: 2.32, 95% CI.: 1.19 − 4.50, <i>p</i> = .01) were also associated with a significantly higher incidence of GDM. Sleep quality and duration emerge as critical risk factors of GDM. Healthcare practitioners should consider targeted interventions to improve sleep hygiene as a potential measure for GDM prevention.
DOI: 10.6084/m9.figshare.27159804.v1
title: Lower serum LH level was related to poor embryo quality and adverse pregnancy outcomes in fixed GnRH antagonist protocol with estradiol pretreatment

description: To disclose the relationships between serum LH and reproductive outcomes in Gonadotropin-releasing hormone (GnRH) antagonist protocol pretreated with luteal estradiol. 371 patients, pretreated with estradiol, followed the GnRH antagonist protocol. They were divided into four groups based on the quartiles of serum LH levels on the day of gonadotropin (Gn) initiation(LH<sub>GI</sub>) and trigger (LH<sub>trigger</sub>). Data on various pregnancy outcomes were collected. As serum LH<sub>GI</sub> increased, anti-Müllerian hormone (AMH) level, antral follicle count (AFC), LH<sub>trigger</sub>, estradiol (E<sub>2</sub>) and P on the trigger day, E<sub>2</sub>/oocytes, and oocyte numbers increased and peaked in Q4, while Gn dose decreased. Good-quality embryo and blast formation rates increased and peaked in Q3. LH<sub>GI</sub> &lt;3.93 mIU/ml impaired ongoing pregnancy rate and LBR. After adjusting for AMH and AFC, the impacts were not significant. As LH<sub>trigger</sub> increased, E<sub>2</sub>/oocytes and good-quality embryo rate increased and peaked in T4 and implantation rate increased and peaked in T3. LH<sub>trigger</sub> &lt;1.49 mIU/ml independently influenced clinical pregnancy rate (CPR) after adjusting for AMH and AFC. LH<sub>GI</sub> was positively related to AMH, AFC, LH<sub>trigger</sub>, blast formation rate and negatively related to BMI, age and Gn dose. LH<sub>trigger</sub> was positively related to E2/oocytes and good quality embryo rate. Lower serum LH represents as a potential indicator for embryo quality and reproductive outcomes in GnRH antagonist fixed protocol pretreated with estradiol. Early identification of excessive suppression of LH levels will benefit individuals with normal ovarian reserve more.
DOI: 10.6084/m9.figshare.27159804
title: Lower serum LH level was related to poor embryo quality and adverse pregnancy outcomes in fixed GnRH antagonist protocol with estradiol pretreatment

description: To disclose the relationships between serum LH and reproductive outcomes in Gonadotropin-releasing hormone (GnRH) antagonist protocol pretreated with luteal estradiol. 371 patients, pretreated with estradiol, followed the GnRH antagonist protocol. They were divided into four groups based on the quartiles of serum LH levels on the day of gonadotropin (Gn) initiation(LH<sub>GI</sub>) and trigger (LH<sub>trigger</sub>). Data on various pregnancy outcomes were collected. As serum LH<sub>GI</sub> increased, anti-Müllerian hormone (AMH) level, antral follicle count (AFC), LH<sub>trigger</sub>, estradiol (E<sub>2</sub>) and P on the trigger day, E<sub>2</sub>/oocytes, and oocyte numbers increased and peaked in Q4, while Gn dose decreased. Good-quality embryo and blast formation rates increased and peaked in Q3. LH<sub>GI</sub> &lt;3.93 mIU/ml impaired ongoing pregnancy rate and LBR. After adjusting for AMH and AFC, the impacts were not significant. As LH<sub>trigger</sub> increased, E<sub>2</sub>/oocytes and good-quality embryo rate increased and peaked in T4 and implantation rate increased and peaked in T3. LH<sub>trigger</sub> &lt;1.49 mIU/ml independently influenced clinical pregnancy rate (CPR) after adjusting for AMH and AFC. LH<sub>GI</sub> was positively related to AMH, AFC, LH<sub>trigger</sub>, blast formation rate and negatively related to BMI, age and Gn dose. LH<sub>trigger</sub> was positively related to E2/oocytes and good quality embryo rate. Lower serum LH represents as a potential indicator for embryo quality and reproductive outcomes in GnRH antagonist fixed protocol pretreated with estradiol. Early identification of excessive suppression of LH levels will benefit individuals with normal ovarian reserve more.
DOI: 10.5281/zenodo.14501735
title: Code and data for "Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome"

description: The zip file contains all the code and data necessary to reproduce the results reported in "Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome". Please refer to the accompanying readme file for instructions.
DOI: 10.5281/zenodo.14501736
title: Code and data for "Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome"

description: The zip file contains all the code and data necessary to reproduce the results reported in "Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome". Please refer to the accompanying readme file for instructions.
DOI: 10.5281/zenodo.13832033
title: DC71_BLM7

description: https://dyncolldev.ht.lu.se/plus/artifact_view.php?item=71
DOI: 10.25345/c5nv99p42
title: MassIVE MSV000096727 - Utilizing Platinum(II)-Based Cross-linker To Investigate Glycogen Phosphorylase
title: Cross-linking mass spectrometry (XL-MS) is widely used in the analysis of protein structure and protein-protein interactions (PPIs). Throughout the entire workflow, the utilization of cross-linkers and the interpretation of cross-linking data are the core steps. Cisplatin, as a well-known anticancer drug, has been previously demonstrated for its capability and advantages as a cross-linker; However, due to the complexity of platinum(II) cross-linked products and the lack of suitable software for data interpretation, it has hindered its further application.
DOI: 10.15468/dl.ethzzz
title: Occurrence Download

description: A dataset containing 114 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Rosa verticillacantha Mérat"
 ]
}

 The dataset includes 114 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047790-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.13880294
title: BLM28314:7_DC71

description: https://dyncolldev.ht.lu.se/plus/artifact_view.php?item=71
DOI: 10.5517/ccdc.csd.cc2gsp21
title: CCDC 2287833: Experimental Crystal Structure Determination

description: Related Article: Daniel E. Felton, Tsuyoshi A. Kohlgruber, Zachary D. Tucker, Eva M. Gulotty, Brandon L. Ashfeld, Peter C. Burns|2023|Cryst.Growth Des.|23|8311|doi:10.1021/acs.cgd.3c00976
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.f86779
title: Occurrence Download

description: A dataset containing 864 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lactuca pulchella (Pursh) DC.",
 "Year 2000-2024"
 ]
}

 The dataset includes 864 records from 64 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047791-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3eyeby
title: Occurrence Download

description: A dataset containing 514 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Canada",
 "TaxonKey is Lactuca pulchella (Pursh) DC.",
 "Year 2000-2024"
 ]
}

 The dataset includes 514 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047792-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14552414
title: The effect of sex on the outcomes of POEM for the treatment of achalasia: a tertiary center study
DOI: 10.5281/zenodo.14552415
title: The effect of sex on the outcomes of POEM for the treatment of achalasia: a tertiary center study
DOI: 10.5281/zenodo.13832167
title: DC73_BLM10

description: https://dyncolldev.ht.lu.se/plus/artifact_view.php?item=73
DOI: 10.5281/zenodo.13880262
title: BLM28314:10_DC73

description: https://dyncolldev.ht.lu.se/plus/artifact_view.php?item=73
DOI: 10.15468/dl.n48h7v
title: Occurrence Download

description: A dataset containing 598 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Oenothera hispida (Benth.) W.L.Wagner, Hoch & Zarucchi"
 ]
}

 The dataset includes 598 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0047794-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14552419
title: Table S1: Concentration data of major and trace elements of the Starkville-South K-Pg boundary slab based on the two integrated-area linescan (IAL) profiles (at 25 µm stratigraphic resolution), following the µ-XRF calibration values displayed in Table 2.

description: Supplementary Table associated with manuscript Kaskes et al. (submitted to Geochemistry, Geophysics, Geosystems in December 2024):

Table S1: Concentration data of major and trace elements of the Starkville-South K-Pg boundary slab based on the two integrated-area linescan (IAL) profiles (at 25 µm stratigraphic resolution), following the µ-XRF calibration values displayed in Table 2.