cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4954115
title: Fused Quinoline Heterocycles X. First Synthesis of New Four Heterocyclic Ring Systems 10-amino-6,9-disubstituted-[1,2,4]triazino[4’,3':1,5]pyrazolo- [4,3-<i>c</i>]quinoline Derivatives

description: A novel, simple, and efficient synthetic methodology for the synthesis of the hitherto unreported tetracyclic 10-amino-6,9-disubstituted-[1,2,4]triazino[4’,3':1,5]pyrazolo[4,3-<i>c</i>]-quinolines, in one step, has been developed by coupling of various active methylene compounds with diazotized heterocyclic amines. Reacting 2,4-dichloroquinoline-3-carbonitrile (<b>1</b>) with cyanoacetic acid hydrazide (<b>2</b>) in the presence of triethylamine in refluxing MeOH gave the unexpected 3-amino-4-chloro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (<b>4</b>), instead of the desired tetracyclic ring system <b>3</b>(Scheme 1). Refluxing <b>4</b> with excess of cyclic secondary amines <b>5a-c</b> in boiling DMF yielded the corresponding 4-amino-pyrazolo[4,3-<i>c</i>]-quinolines <b>6a-c</b>. Diazotization of compounds <b>4</b> and <b>6a-c</b> with sodium nitrite and concentrated HCl at -5 °C gave the corresponding diazonium salts <b>17a-d</b>, which were then subjected to couple with different active methylene nitriles, namely 2-cyanothioacetamide (<b>12</b>), ethyl cyanoacetate (<b>13</b>), malononitrile (<b>14</b>), 2-cyanoacetamide (<b>15</b>) and 2-cyano-<i>N</i>-phenylacetamide (<b>16</b>), in aqueous ethanol containing sodium acetate as a buffer solution. The coupling reaction of diazonium salts <b>17</b> with <b>12, 13</b> and<b>14</b> leading to the novel perianellated tetracyclic ring system 10-amino-6,9-disubstituted-[1,2,4]triazino[4′,3′:1,5]pyrazolo[4,3-<i>c</i>]quinolines <b>19, 23</b> and <b>27</b>, respectively, in one step, is described for the first time. On the other hand, coupling reaction of diazonium salt <b>17a</b> with both<b>15</b> and <b>16</b> yielded the previously unknown tetracyclic 10-amino-6-chloro-[1,2,4]triazino-[4’,3':1,5]pyrazolo[4,3-<i>c</i>]quinoline-9-carboxamides <b>28a</b> and <b>28b</b>, respectively (Scheme 6). No chromatographic techniques have been employed for the purification of the products. The structures of all the newly synthesized compounds were unambiguously confirmed by spectroscopic and analytical techniques.
DOI: 10.6084/m9.figshare.4954115.v1
title: Fused quinoline heterocycles X. First synthesis of new four heterocyclic ring systems 10-amino-6,9-disubstituted-[1,2,4]triazino[4′,3′:1,5]pyrazolo[4,3-<i>c</i>]quinoline derivatives

description: A novel, simple, and efficient synthetic methodology for the synthesis of hitherto unreported tetracyclic 10-amino-6,9-disubstituted-[1,2,4]triazino[4′,3′:1,5]pyrazolo[4,3-<i>c</i>]quinolines, in one step, has been developed by coupling of various active methylene compounds with diazotized heterocyclic amines. Reacting 2,4-dichloroquinoline-3-carbonitrile (<b>1</b>) with cyanoacetic acid hydrazide (<b>2</b>) in the presence of triethylamine in refluxing MeOH gave the unexpected 3-amino-4-chloro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (<b>4</b>), instead of the desired tetracyclic ring system <b>3</b> (Scheme 1). Refluxing <b>4</b> with excess of cyclic secondary amines <b>5a–c</b> in boiling dimethylformamide yielded the corresponding 4-amino-pyrazolo[4,3-<i>c</i>]quinolines <b>6a–c</b>. Diazotization of compounds <b>4</b> and <b>6a–c</b> with sodium nitrite and concentrated HCl at −5 °C gave the corresponding diazonium salts <b>17a–d</b>, which were then subjected to couple with different active methylene nitriles, namely, 2-cyanothioacetamide (<b>12</b>), ethyl cyanoacetate (<b>13</b>), malononitrile (<b>14</b>), 2-cyanoacetamide (<b>15</b>), and 2-cyano-<i>N</i>-phenylacetamide (<b>16</b>), in aqueous ethanol containing sodium acetate as a buffer solution. The coupling reaction of diazonium salts <b>17</b> with <b>12, 13</b>, and <b>14</b> leading to the novel perianellated tetracyclic ring system 10-amino-6,9-disubstituted-[1,2,4]triazino[4′,3′:1,5]pyrazolo[4,3-<i>c</i>]quinolines <b>19, 23</b>, and <b>27</b>, respectively, in one step, is described for the first time. On the other hand, coupling reaction of diazonium salt <b>17a</b> with both <b>15</b> and <b>16</b> yielded the previously unknown tetracyclic 10-amino-6-chloro-[1,2,4]triazino[4′,3′:1,5]pyrazolo[4,3-<i>c</i>]quinoline-9-carboxamides <b>28a</b> and <b>28b</b>, respectively (Scheme 6). No chromatographic techniques have been used for the purification of the products. The structures of all the newly synthesized compounds were unambiguously confirmed by spectroscopic and analytical techniques.
DOI: 10.6084/m9.figshare.4954202.v1
title: Human Embryonic Craniofacial Tissue Epigenomic Data and Chromatin State Segmentations from the Cotney Lab at UConn Health

description: Human Embryonic Craniofacial Tissue Epigenomic Data and Chromatin State Segmentations from the Cotney Lab at UConn Health
DOI: 10.6084/m9.figshare.4954040
title: Intraocular Cytokine Levels in Post-Cataract Endophthalmitis and their Association with Visual Outcome

description: <i>Purpose</i>: The host immune reaction during endophthalmitis, studied in particular through the intraocular cytokine network, is essential for the comprehension of the disease and the development of new therapies. Therefore, the purpose of this study was to elucidate the cytokine composition of aqueous humor during endophthalmitis. <i>Methods</i>: In a multicenter case-control study, forty-nine patients with postoperative endophthalmitis and 60 controls (cataract surgery) were included. Visual acuity, local inflammatory grading, medical history and intraocular levels of 27 cytokines and chemokines (measured by multiplex immunoassay) were recorded. <i>Results</i>: During endophtalmitis, an increase in total cytokines was observed. The raise of Th1 cytokines was particularly noticeable. Chemokines, such as IL-8, MIP-1 β, MCP-1, G-CSF and IP-10, also increased. Pearson’s correlation analyses showed a poor visual prognosis with high levels of IL-8, MCP-1 and VEGF and a low level of IL-10 at admission. <i>Conclusion</i>: An increase in inflammatory cytokines is noticeable during endophthalmitis, with a particular emphasis on IL-8, MCP-1 and VEGF. Targeted anti-inflammatory and anti-VEGF treatments may be of interest in the future.
DOI: 10.6084/m9.figshare.4954067
title: Degradation of protein translation machinery by amino acid starvation-induced macroautophagy

description: Macroautophagy is regarded as a nonspecific bulk degradation process of cytoplasmic material within the lysosome. However, the process has mainly been studied by nonspecific bulk degradation assays using radiolabeling. In the present study we monitor protein turnover and degradation by global, unbiased approaches relying on quantitative mass spectrometry-based proteomics. Macroautophagy is induced by rapamycin treatment, and by amino acid and glucose starvation in differentially, metabolically labeled cells. Protein dynamics are linked to image-based models of autophagosome turnover. Depending on the inducing stimulus, protein as well as organelle turnover differ. Amino acid starvation-induced macroautophagy leads to selective degradation of proteins important for protein translation. Thus, protein dynamics reflect cellular conditions in the respective treatment indicating stimulus-specific pathways in stress-induced macroautophagy.
DOI: 10.6084/m9.figshare.4954067.v1
title: Degradation of protein translation machinery by amino acid starvation-induced macroautophagy

description: Macroautophagy is regarded as a nonspecific bulk degradation process of cytoplasmic material within the lysosome. However, the process has mainly been studied by nonspecific bulk degradation assays using radiolabeling. In the present study we monitor protein turnover and degradation by global, unbiased approaches relying on quantitative mass spectrometry-based proteomics. Macroautophagy is induced by rapamycin treatment, and by amino acid and glucose starvation in differentially, metabolically labeled cells. Protein dynamics are linked to image-based models of autophagosome turnover. Depending on the inducing stimulus, protein as well as organelle turnover differ. Amino acid starvation-induced macroautophagy leads to selective degradation of proteins important for protein translation. Thus, protein dynamics reflect cellular conditions in the respective treatment indicating stimulus-specific pathways in stress-induced macroautophagy.
DOI: 10.6084/m9.figshare.4954040.v1
title: Intraocular Cytokine Levels in Post-Cataract Endophthalmitis and their Association with Visual Outcome

description: <i>Purpose</i>: The host immune reaction during endophthalmitis, studied in particular through the intraocular cytokine network, is essential for the comprehension of the disease and the development of new therapies. Therefore, the purpose of this study was to elucidate the cytokine composition of aqueous humor during endophthalmitis. <i>Methods</i>: In a multicenter case-control study, forty-nine patients with postoperative endophthalmitis and 60 controls (cataract surgery) were included. Visual acuity, local inflammatory grading, medical history and intraocular levels of 27 cytokines and chemokines (measured by multiplex immunoassay) were recorded. <i>Results</i>: During endophtalmitis, an increase in total cytokines was observed. The raise of Th1 cytokines was particularly noticeable. Chemokines, such as IL-8, MIP-1 β, MCP-1, G-CSF and IP-10, also increased. Pearson’s correlation analyses showed a poor visual prognosis with high levels of IL-8, MCP-1 and VEGF and a low level of IL-10 at admission. <i>Conclusion</i>: An increase in inflammatory cytokines is noticeable during endophthalmitis, with a particular emphasis on IL-8, MCP-1 and VEGF. Targeted anti-inflammatory and anti-VEGF treatments may be of interest in the future.
DOI: 10.6084/m9.figshare.4953929
title: Results on how frequently social decision schemes violate desirable properties

description: Results of our study on how frequently social decision schemes (SDSs) violate desirable properties under stochastic dominance. The examined SDSs are Random Serial Dictatorship (RSD) and Maximal Lottery (ML).<br>It was previously shown that efficiency and strategyproofness are incompatible under the assumption of some basic fairness conditions.<br><br>We consider efficiency, strategyproofness, monotonicity, very strong participation, envy-freeness on the assignment domain and give a support size analysis for ML.
DOI: 10.6084/m9.figshare.4953929.v1
title: Results on how frequently social decision schemes violate desirable properties

description: Results of our study on how frequently social decision schemes (SDSs) violate desirable properties under stochastic dominance. The examined SDSs are Random Serial Dictatorship (RSD) and Maximal Lottery (ML).<br>It was previously shown that efficiency and strategyproofness are incompatible under the assumption of some basic fairness conditions.<br><br>We consider efficiency, strategyproofness, monotonicity, very strong participation, envy-freeness on the assignment domain and give a support size analysis for ML.
DOI: 10.6084/m9.figshare.4944761
title: Vibrio vulnificus Clinical Isolates RNA-Seq

description: RNA-Seq raw FASTQ files from Vibrio vulnificus CMCP6 and YJ016 strains. Comparison in artificial seawater (ASW) vs. human serum (HS) environments. Paired end, 2 replicates per condition.
DOI: 10.6084/m9.figshare.4944761.v2
title: Vibrio vulnificus Clinical Isolates RNA-Seq

description: RNA-Seq raw FASTQ files from Vibrio vulnificus CMCP6 and YJ016 strains. Comparison in artificial seawater (ASW) vs. human serum (HS) environments. Paired end, 2 replicates per condition.
DOI: 10.6084/m9.figshare.4944761.v4
title: Vibrio vulnificus Clinical Isolates RNA-Seq

description: RNA-Seq raw FASTQ files from Vibrio vulnificus CMCP6 and YJ016 strains. Comparison in artificial seawater (ASW) vs. human serum (HS) environments. Paired end, 2 replicates per condition.
DOI: 10.6084/m9.figshare.4944761.v3
title: Vibrio vulnificus Clinical Isolates RNA-Seq

description: RNA-Seq raw FASTQ files from Vibrio vulnificus CMCP6 and YJ016 strains. Comparison in artificial seawater (ASW) vs. human serum (HS) environments. Paired end, 2 replicates per condition.
DOI: 10.6084/m9.figshare.4944188
title: Cortical Structures Associated With Sports Participation in Children: A Population-Based Study

description: We studied cortical morphology in relation to sports participation and type of sport using a large sample of healthy children (<i>n</i> = 911). Sports participation data was collected through a parent-reported questionnaire. Magnetic resonance scans were acquired, and different morphological brain features were quantified. Global volumetric measures were not associated with sports participation. We observed thicker cortex in motor and premotor areas associated with sports participation. In boys, team sports participation, relative to individual sports, was related to thinner cortex in prefrontal brain areas involved in the regulation of behaviors. This study showed a relationship between sports participation and brain maturation.
DOI: 10.6084/m9.figshare.4944188.v1
title: Cortical Structures Associated With Sports Participation in Children: A Population-Based Study

description: We studied cortical morphology in relation to sports participation and type of sport using a large sample of healthy children (<i>n</i> = 911). Sports participation data was collected through a parent-reported questionnaire. Magnetic resonance scans were acquired, and different morphological brain features were quantified. Global volumetric measures were not associated with sports participation. We observed thicker cortex in motor and premotor areas associated with sports participation. In boys, team sports participation, relative to individual sports, was related to thinner cortex in prefrontal brain areas involved in the regulation of behaviors. This study showed a relationship between sports participation and brain maturation.
DOI: 10.6084/m9.figshare.12906485.v2
title: Data Giroux 2020.xlsx

description: Embodiment and kinaesthesia scores (speed, duration) from two experiments (Giroux et al)
DOI: 10.25430/researchdata.cab.unipd.it.00000375
title: Monitoring and modeling drainage network contraction and dry down in Mediterranean headwater catchments

description: The dataset contanins data relative to the field surveys of the active network, related to the manuscript "Monitoring and modeling drainage network contraction and dry down in Mediterranean headwater catchments".
DOI: 10.17633/rd.brunel.4939391
title: Is sociopolitical egalitarianism related to bodily and facial formidability in men? Dataset

description: Data used for: Price, M. E., Sheehy-Skeffington, J., Sidanius, J., Pound, N. (In press). Is sociopolitical egalitarianism related to bodily and facial formidability in men? <em>Evolution and Human Behavior.</em>
DOI: 10.17633/rd.brunel.4939391.v1
title: Is sociopolitical egalitarianism related to bodily and facial formidability in men? Dataset

description: Data used for: Price, M. E., Sheehy-Skeffington, J., Sidanius, J., Pound, N. (In press). Is sociopolitical egalitarianism related to bodily and facial formidability in men? <em>Evolution and Human Behavior.</em>
DOI: 10.6084/m9.figshare.4937684
title: Data from: Transcriptomic differentiation underlying marine-to-freshwater transitions in the South American silversides Odontesthes argentinensis and O. bonariensis (Atheriniformes)

description: These are datafiles associated with the paper Hughes LC, Somoza GM, Nguyen BN, et al. Transcriptomic differentiation underlying marine- to- freshwater transitions in the South American silversides Odontesthes argentinensis and O. bonariensis (Atheriniformes). Ecol Evol. 2017;00:1–11. https://doi.org/10.1002/ece3.3133
DOI: 10.6084/m9.figshare.4937684.v1
title: Data from: Transcriptomic differentiation underlying marine-to-freshwater transitions in the South American silversides Odontesthes argentinensis and O. bonariensis (Atheriniformes)

description: These are datafiles associated with the paper Hughes LC, Somoza GM, Nguyen BN, et al. Transcriptomic differentiation underlying marine- to- freshwater transitions in the South American silversides Odontesthes argentinensis and O. bonariensis (Atheriniformes). Ecol Evol. 2017;00:1–11. https://doi.org/10.1002/ece3.3133
DOI: 10.6084/m9.figshare.4937183
title: ACTwatch Outlet Survey Files: Uganda 2013

description: ACTwatch Uganda 2013 files This collection contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Uganda 2013 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4936559
title: ACTwatch Outlet Survey Files: Nigeria 2013

description: ACTwatch Nigeria 2013 files This collection contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Nigeria 2013 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4936301
title: Rani CD4CD8 Plos One data set

description: Data set for Plos One submission: The Composition of T-Cell Subsets are Altered in the Burn Wound Early After Injury
DOI: 10.6084/m9.figshare.4936301.v1
title: Rani CD4CD8 Plos One data set

description: Data set for Plos One submission: The Composition of T-Cell Subsets are Altered in the Burn Wound Early After Injury
DOI: 10.6084/m9.figshare.12906524
title: Morphometric data of Cardiocondyla obscurior workers

description: Quantitative measurements of four morphological traits (EY, HL, SP, ML) of workers of the myrmicine ant species Cardiocondyla obscurior. Workers were collected from control colonies (C), 17-DMAG-treated colonies (T), and from two natural populations in Brazil (BR) and Spain (SP). <br>
DOI: 10.6084/m9.figshare.12906524.v1
title: Morphometric data of Cardiocondyla obscurior workers

description: Quantitative measurements of four morphological traits (EY, HL, SP, ML) of workers of the myrmicine ant species Cardiocondyla obscurior. Workers were collected from control colonies (C), 17-DMAG-treated colonies (T), and from two natural populations in Brazil (BR) and Spain (SP). <br>
DOI: 10.6084/m9.figshare.4933325
title: Supplementary Datasets from Spatial patterns of Anchoveta (<i>Engraulis ringens</i>) eggs and larvae in relation to <i>p</i>CO<sub>2</sub> in the Peruvian upwelling system

description: Datasets for oceanographic variables, eggs, and larvae
DOI: 10.6084/m9.figshare.4933325.v1
title: Supplementary Datasets from Spatial patterns of Anchoveta (<i>Engraulis ringens</i>) eggs and larvae in relation to <i>p</i>CO<sub>2</sub> in the Peruvian upwelling system

description: Datasets for oceanographic variables, eggs, and larvae
DOI: 10.6084/m9.figshare.4933292
title: Experimental data from Adhesion modulation using glue droplet spreading in spider capture silk

description: Raw data for the adhesion experiments presented in the manuscript
DOI: 10.6084/m9.figshare.4933292.v1
title: Experimental data from Adhesion modulation using glue droplet spreading in spider capture silk

description: Raw data for the adhesion experiments presented in the manuscript
DOI: 10.5258/soton/d1507
title: Data set for Nonlinear properties of laser-processed polycrystalline silicon waveguides for integrated photonics

description: This dataset supports the publication: Ozan Aktas, Swe Z. Oo, Stuart J. MacFarquhar, Antulio Tarazona, Harold M. H. Chong, and Anna C. Peacock (2020) Nonlinear properties of laser-processed polycrystalline silicon waveguides for integrated photonics. Optics Express. The excel file contains all experimental and simulation data used for generating Fig.3 to Fig.6.
DOI: 10.6084/m9.figshare.4930082
title: Processed data freeze for Jupyter notebooks

description: Freeze of processed data for the Jupyter Notebooks accompanying the manuscript "Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma" by Kas, S.M., de Ruiter, J.R. and Schipper, K et al. in Nature Genetics, 2017.<br>Can be used to recreate the results in the notebooks without re-running the sequencing pipelines.<br><br>
DOI: 10.6084/m9.figshare.4930082.v1
title: Processed data freeze for Jupyter notebooks

description: Freeze of processed data for the Jupyter Notebooks accompanying the manuscript "Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma" by Kas, S.M., de Ruiter, J.R. and Schipper, K et al. in Nature Genetics, 2017.<br>Can be used to recreate the results in the notebooks without re-running the sequencing pipelines.<br><br>
DOI: 10.6084/m9.figshare.4929866
title: Processed expression and insertion datasets

description: Processed RNA-sequencing and insertion datasets accompanying the manuscript "Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma" by Kas, S.M., de Ruiter, J.R. and Schipper, K et al. in Nature Genetics, 2017.<br>