cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29069168.v1
title: Supplementary Material for: Long-Term Longitudinal Analysis of Pulmonary Function Before and After Biological Therapy in Severe Asthma

description: Background: Biological agents are essential treatment options for severe asthma, particularly in cases with Type 2 (T2) inflammation, due to their ability to improve symptoms, prevent exacerbations, and reduce the use of oral corticosteroids. However, limited data exist regarding their long-term effects on lung function, particularly on forced expiratory volume in one second (FEV₁). This study aimed to analyze the longitudinal changes in FEV₁ before and after the initiation of biological agents by following cases over an extended period. 
Methods: This study included patients with at least three spirometric measurements before and after the initiation of biological agents, and a follow-up period of at least two years. The primary outcome was the annual change in FEV₁ (ΔFEV₁). Secondary outcomes included comparisons between patients with improved and deteriorated ΔFEV₁, differences based on the type of biological agent used, and comparisons between patients who achieved clinical remission and those who did not. 
Results: A total of 41 patients with severe asthma were analyzed. The overall ΔFEV₁ significantly improved after the introduction of biological agents (p &lt; 0.001). Patients with greater declines in FEV₁ prior to treatment showed more pronounced improvements, especially among those treated with anti-IL-5 biologics (mepolizumab and benralizumab) or anti-IL-4 receptor antibodies (p = 0.016 and p = 0.026, respectively). Furthermore, patients with elevated T2 inflammation biomarkers, such as fractional exhaled nitric oxide (FeNO) and peripheral blood eosinophil count (PBE), exhibited greater improvements in FEV₁. 
Conclusion: This study indicates that biological agents may help prevent the progressive decline in lung function in severe asthma, particularly among patients with significantly declined lung function or elevated T2 inflammation biomarkers before treatment. Further research is needed to explore differences in efficacy across various biological agents.
DOI: 10.6084/m9.figshare.29069171
title: Supplementary Material for: High Diagnostic Yield of Next Generation Sequencing in Charcot Marie Tooth Patients and a Novel Variant in the NDRG1 Gene

description: Introduction:Charcot-Marie-Tooth (CMT) is a disorder that encompasses a group of hereditary neuropathies. The clinical features of CMT is variable due to genetic heterogeneity. This study aimed to evaluate the utility of targated next-generation sequencing (NGS) panels in the molecular diagnosis of CMT in routine clinical practice and to determine the causative genetic variants. Methods: NGS was used to detect the causative single nucleotid variants in 55 genes associated with CMT alongside multiplex ligation probe amplification (MLPA) for copy number variation (CNV) analysis of the PMP22 gene. The period from the first clinical findings to genetic testing was considered as the 'diagnostic odyssey'. Results: A total of 58 patients with suspected CMT were analysed. MLPA was performed on 54 patients, while 4 underwent direct NGS due to suspicion of other CMT types. MLPA revealed pathogenic CNVs in 21 patients (36.2%). Among the 33 patients with negative MLPA results, 24 underwent NGS. Pathogenic / likely pathogenic variants were identified in 17 (60.7%) of total 28 patients. Overall, the diagnostic yield was 65.5% (38/58). Moreover, a novel likely pathogenic variant (c.637C&gt;T) was detected in the NDRG1 gene. The average diagnostic odyssey in diagnosed patients was 5.6 years. Conclusion:Targeted NGS panels are a highly effective tool for the genetic diagnosis of CMT and increase the diagnostic rates when used in conjunction with MLPA. Molecular genetic diagnosis is critical for CMT patients, particularly in light of ongoing research into targeted therapies. Furthermore, presence of undiagnosed cases underscores the likelihood that additional causative genes and mechanisms in CMT etiology remain to be discovered.
DOI: 10.6084/m9.figshare.29069171.v1
title: Supplementary Material for: High Diagnostic Yield of Next Generation Sequencing in Charcot Marie Tooth Patients and a Novel Variant in the NDRG1 Gene

description: Introduction:Charcot-Marie-Tooth (CMT) is a disorder that encompasses a group of hereditary neuropathies. The clinical features of CMT is variable due to genetic heterogeneity. This study aimed to evaluate the utility of targated next-generation sequencing (NGS) panels in the molecular diagnosis of CMT in routine clinical practice and to determine the causative genetic variants. Methods: NGS was used to detect the causative single nucleotid variants in 55 genes associated with CMT alongside multiplex ligation probe amplification (MLPA) for copy number variation (CNV) analysis of the PMP22 gene. The period from the first clinical findings to genetic testing was considered as the 'diagnostic odyssey'. Results: A total of 58 patients with suspected CMT were analysed. MLPA was performed on 54 patients, while 4 underwent direct NGS due to suspicion of other CMT types. MLPA revealed pathogenic CNVs in 21 patients (36.2%). Among the 33 patients with negative MLPA results, 24 underwent NGS. Pathogenic / likely pathogenic variants were identified in 17 (60.7%) of total 28 patients. Overall, the diagnostic yield was 65.5% (38/58). Moreover, a novel likely pathogenic variant (c.637C&gt;T) was detected in the NDRG1 gene. The average diagnostic odyssey in diagnosed patients was 5.6 years. Conclusion:Targeted NGS panels are a highly effective tool for the genetic diagnosis of CMT and increase the diagnostic rates when used in conjunction with MLPA. Molecular genetic diagnosis is critical for CMT patients, particularly in light of ongoing research into targeted therapies. Furthermore, presence of undiagnosed cases underscores the likelihood that additional causative genes and mechanisms in CMT etiology remain to be discovered.
DOI: 10.6084/m9.figshare.29069174
title: Supplementary Material for: A new family with X-linked intellectual disability-90: A case report of a novel DLG3 variant and literature review

description: Abstract
Introduction: X-linked intellectual disability (XLID) is a highly heterogeneous disease. Apart from Fragile X, other diseases that cause XLID are quite rare. The DLG3 gene variants cause XLID90. 
Case presentation: This study presents two patients diagnosed with XLID90 after identifying a novel variant in the DLG3 gene through whole exome sequencing analysis. Both patients had autism spectrum disorder (ASD), intellectual disability (ID), and dysmorphism. Additionally, an arachnoid cyst, which has not been previously reported in XLID90, was also detected in the patients. XLID90 has neither specific clinical findings nor dysmorphic features. Therefore, a detailed literature review is essential for clearly elucidating the phenotype. Here, 102 XLID90 cases from 18 publications reporting pathogenic variants in the DLG3 gene were reviewed to investigate the detailed clinical findings among these patients. The literature review has shown that ID is more frequently observed in patients with truncating variants, while seizures are more commonly seen in patients with non-truncating variants.
Conclusion: This study will provide homogeneous healthcare to patients and allow for appropriate genetic counseling.
DOI: 10.6084/m9.figshare.29069177
title: Supplementary Material for: Secondary ocular hypertension with exophthalmos as the first presentation of endogenous Cushing’s syndrome

description: Introduction: Cushing's syndrome results from excessive exposure to exogenous or endogenous steroid, while cushing's disease is hypercortisolism from an adrenocorticotropic hormone-secreting pituitary adenoma. Secondary ocular hypertension (OHT) accompanied by exophthalmos as the initial presentation of endogenous Cushing’s syndrome has rarely been reported.
Case Presentation: A 46-year-old Thai woman was referred for OHT treatment despite maximum tolerance to medication. Intraocular pressure (IOP) was 21 mmHg (right eye) and 25 mmHg (left eye). Visual acuity was 20/20 in both eyes. Bilateral eyelids were swollen without any palpable masses. Exophthalmometer measurements were 24 mm (right eye) and 23 mm (left eye). Extraocular muscle movements, anterior segment, gonioscopy and dilated fundoscopic exams were normal bilaterally. Optic nerve head was unremarkable in both eyes. Optical coherence tomography showed marginal inferior thinning of the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) in left eye. Computerized visual field 24-2 was normal bilaterally. She was diagnosed with secondary OHT with exophthalmos in both eyes. Thyroid function and thyroid antibody tests were unremarkable. Orbital and brain computed tomography revealed exophthalmos with an increase of retrobulbar fat bilaterally and a hypodense pituitary lesion. She was diagnosed with Cushing’s disease and underwent endoscopic transsphenoidal adenectomy. At six-month postoperatively, IOP decreased to 16 mmHg (right eye) and 17 mmHg (left eye), without any IOP-lowering medications. Exophthalmos also improved as exophthalmometer measurements were 20 mm (right eye) and 19 mm (left eye).
Conclusions: Endogenous Cushing's syndrome should be included in the differential diagnosis of secondary OHT with exophthalmos.
DOI: 10.6084/m9.figshare.29069177.v1
title: Supplementary Material for: Secondary ocular hypertension with exophthalmos as the first presentation of endogenous Cushing’s syndrome

description: Introduction: Cushing's syndrome results from excessive exposure to exogenous or endogenous steroid, while cushing's disease is hypercortisolism from an adrenocorticotropic hormone-secreting pituitary adenoma. Secondary ocular hypertension (OHT) accompanied by exophthalmos as the initial presentation of endogenous Cushing’s syndrome has rarely been reported.
Case Presentation: A 46-year-old Thai woman was referred for OHT treatment despite maximum tolerance to medication. Intraocular pressure (IOP) was 21 mmHg (right eye) and 25 mmHg (left eye). Visual acuity was 20/20 in both eyes. Bilateral eyelids were swollen without any palpable masses. Exophthalmometer measurements were 24 mm (right eye) and 23 mm (left eye). Extraocular muscle movements, anterior segment, gonioscopy and dilated fundoscopic exams were normal bilaterally. Optic nerve head was unremarkable in both eyes. Optical coherence tomography showed marginal inferior thinning of the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) in left eye. Computerized visual field 24-2 was normal bilaterally. She was diagnosed with secondary OHT with exophthalmos in both eyes. Thyroid function and thyroid antibody tests were unremarkable. Orbital and brain computed tomography revealed exophthalmos with an increase of retrobulbar fat bilaterally and a hypodense pituitary lesion. She was diagnosed with Cushing’s disease and underwent endoscopic transsphenoidal adenectomy. At six-month postoperatively, IOP decreased to 16 mmHg (right eye) and 17 mmHg (left eye), without any IOP-lowering medications. Exophthalmos also improved as exophthalmometer measurements were 20 mm (right eye) and 19 mm (left eye).
Conclusions: Endogenous Cushing's syndrome should be included in the differential diagnosis of secondary OHT with exophthalmos.
DOI: 10.15468/dl.eqhrpz
title: Occurrence Download

description: A dataset containing 242 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Willughbeia edulis Roxb."
 ]
}

 The dataset includes 242 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032460-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7939/r3kk94t19
title: BoardEx Reports - SMDEs Profiles - Set 1 - 2018 April

description: SMDE - senior management, disclosed earners - profiles. Includes: North America (NA) - SMDEs Profile - Characteristics (4 files); North America (NA) - SMDEs Profile - Education & Achievements; North America (NA) - SMDEs Profile - Employment Current Board; North America (NA) - SMDEs Profile - Employment Current NonBoard; North America (NA) - SMDEs Profile - Employment Historical Board; North America (NA) - SMDEs Profile - Employment Historical NonBoard (4 files); NA - SMDEs Profile - Other Activities
DOI: 10.15468/dl.8mww3w
title: Occurrence Download

description: A dataset containing 443229 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Empetrum L."
 ]
}

 The dataset includes 443229 records from 638 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032450-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57967/hf/5439
title: mmrag_benchmark
DOI: 10.57967/hf/5475
title: mmrag_benchmark
DOI: 10.15468/dl.mnx8p3
title: Occurrence Download

description: A dataset containing 7056 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Withania somnifera (L.) Dunal"
 ]
}

 The dataset includes 7056 records from 210 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032461-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15421405
title: National Research Projects and Their Impact on Scientific Production

description: Conjunto de datos relativos: 

Los proyectos nacionales de investigación y su impacto en la producción científica. El caso de la Universidad de Granada (2018-2023).
DOI: 10.7939/r3-dk7b-ge53
title: Boardex Reports - SMDEs Org Summaries - Set 2 - 2019 April

description: SMDEs org summary reports include information on individual SMDEs (senior management, disclosed earners). Includes: North America (NA) - SMDEs Org Summary (5 files).
DOI: 10.7939/r3cr5nq9c
title: BoardEx Reports - SMDEs Profiles - Set 1 - 2017 April

description: SMDE - senior management, disclosed earners - profiles. Includes: North America (NA) - SMDEs Profile - Characteristics North America (NA) - SMDEs Profile - Education & Achievements North America (NA) - SMDEs Profile - Employment North America (NA) - SMDEs Profile - Employment Historical NonBoard North America (NA) - SMDEs Profile - Other Activities Rest of World (ROW) - SMDEs Profile - Characteristics Rest of World (ROW) - SMDEs Profile - Education & Achievements Rest of World (ROW) - SMDEs Profile - Employment Rest of World (ROW) - SMDEs Profile - Employment Historical NonBoard Rest of World (ROW) - SMDEs Profile - Other Activities
DOI: 10.15468/dl.wxpyq4
title: Occurrence Download

description: A dataset containing 98 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "Geometry POLYGON((-98.7 20.6,-98.7 19.6,-97.4 19.6,-97.4 20.6,-98.7 20.6))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Sedum L.",
 "Year 2000-2025"
 ]
}

 The dataset includes 98 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032466-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6pud3y
title: Occurrence Download

description: A dataset containing 6541 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vernonia cinerea (L.) Less."
 ]
}

 The dataset includes 6541 records from 269 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032464-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7939/r3-x6je-g824
title: Boardex Reports - Director Network UK - 2021 November
DOI: 10.7939/r3-h7e4-w695
title: BoardEx Reports - Board Summaries - 2020 December

description: Board Summary Reports provide information on individual members of boards of directors (by name) including: director role & experience and committee membership. Data goes back to 1999 when available.
DOI: 10.15468/dl.abgv4v
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Empodesma Moore & Jeffords, 1945"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032467-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7939/r30v89t5d
title: BoardEx Reports - SMDEs Profiles - Set 2 - 2016 April

description: SMDE - senior management, disclosed earners - profiles. Includes: <br> Europe - SMDEs Profile - Characteristics<br> Europe - SMDEs Profile - Education & Achievements<br> Europe - SMDEs Profile - Employment<br> Europe - SMDEs Profile - Employment Historical NonBoard<br> Europe - SMDEs Profile - Other Activities<br> UK - SMDEs Profile - Characteristics<br> UK- SMDEs Profile - Education & Achievements<br> UK - SMDEs Profile - Employment<br> UK - SMDEs Profile - Employment Historical NonBoard<br> UK - SMDEs Profile - Other Activities<br>
DOI: 10.15468/dl.necgr8
title: Occurrence Download

description: A dataset containing 98 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "Geometry POLYGON((-98.7 20.6,-98.7 19.6,-97.4 19.6,-97.4 20.6,-98.7 20.6))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Sedum L.",
 "Year 2000-2025"
 ]
}

 The dataset includes 98 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032468-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29069159
title: Dataset for D-shaped Fiber Sensor with Different Polishing Lengths

description: This is the dataset of the RI sensor based on a D-shaped fiber structure for a paper under review in a Web of Science-indexed journal.
DOI: 10.7939/r3-fp9e-bk98
title: Boardex Reports - Company Details - 2020 April

description: Company details include address, home office url, ticker, industry sector, market capitalization, revenue and auditors. Includes: Europe - Company Details; North America (NA) - Company Details; Rest of the World (ROW) - Company Details; and UK - Company Details.
DOI: 10.7939/r3xg36
title: BoardEx Reports - Director Profiles - Set 2 - 2016 April

description: Director Profiles provide data on individual directors by ID number including: age, gender, education, number of boards on, achievements, board role ( current and historic) , and other activities (current and historic). Data back to 1999 when available. Includes: <br> Europe - Director Profile - Characteristics<br> Europe - Director Profile - Education & Achievements<br> Europe - Director Profile - Employment<br> Europe - Director Profile - Other Activities<br> UK - Director Profile - Characteristics<br> UK - Director Profile - Education & Achievements<br> UK - Director Profile - Employment<br> UK - Director Profile - Other Activities<br>
DOI: 10.15468/dl.pb7gru
title: Occurrence Download

description: A dataset containing 9204339 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Kusnezoviella chalchica Emeljanov, 1972, Chaetopteroplia segetum (Herbst, 1783), Bucephala clangula (Linnaeus, 1758), Acrolophus plumifrontella Clemens, 1859, Eurytoma saussureae Zerova, 1995, Pseudopanurgus virginicus (Cockerell, 1907), Olethreutes ferriferana (Walker, 1863), Loepa formosensis Mell, 1939, Epilachna sauteri (Weise, 1923), Xaniona galacta Zhang & Huang, 2005, Hydrellia limnobii Deonier, 1993, Heterotis niloticus (Cuvier, 1829), Rhinogobius giurinus (Rutter, 1897), Phoxinus phoxinus (Linnaeus, 1758), Cottus gobio Linnaeus, 1758, Esox lucius Linnaeus, 1758, Squalius cephalus (Linnaeus, 1758), Leuciscus leuciscus (Linnaeus, 1758), Australoheros facetus (Jenyns, 1842), Schistosoma mansoni Sambon, 1907, Angiostrongylus costaricensis Morera & Céspedes, 1971, Percichthys colhuapiensis MacDonagh, 1955, Percichthys trucha (Valenciennes, 1833), Odontesthes hatcheri (Eigenmann, 1909), Planaria torva (O.F.Müller, 1773), Polycelis tenuis Ijima, 1884, Thamnophis validus celaeno (Cope, 1861), Echinostoma macrorchis Ando & Ozaki, 1923, Schistosoma intercalatum Fisher, 1934, Schistosoma haematobium (Bilharz, 1852) Weinland, 1858, Schistosoma bovis (Looss, 1876) Blanchard, 1895, Brevibacillus brevis_C, Lanistes varicus (O.F.Müller, 1774), Belostoma flumineum Say, 1832, Procambarus alleni (Faxon, 1884), Angiostrongylus cantonensis (Chen, 1935), Angiostrongylus vasorum (Baillet, 1866), Fasciola nyanzae Leiper, 1910, Calicophoron daubneyi Dinnik, 1962, Echinostoma caproni Richard, 1964, Hypoderaeum conoideum (Bloch, 1782) Dietz, 1909, Echinostoma revolutum (Fröhlich, 1802) Looss, 1899, Echinostoma miyagawai Ishii, 1932, Trichobilharzia regenti Horak, Kolarova & Dvorak, 1998, Fascioloides magna (Bassa, 1875), Trichobilharzia ocellata (La Valette St.George, 1855) Brumpt, 1931, Dendrocoelum lacteum (Müller, 1774), Erpobdella octoculata (Linnaeus, 1758), Trichobilharzia franki Müller & Kimmig, 1994, Tinca tinca (Linnaeus, 1758))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 9204339 records from 1899 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032446-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/4mw-edk-nys
title: Erigeron caucasicus Steven

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/bpn-p2y-lkj
title: Cirsium acaulon subsp. gregarium (Boiss. ex DC.) Talavera

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/vfd-vsx-bdf
title: Senecio sylvaticus L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/d6c-zc0-hes
title: Crepis capillaris (L.) Wallr.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/qfk-kes-e3r
title: Paeonia coriacea Boiss.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/1fj-pgl-5dc
title: Melica L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/e2e-pp9-wt4
title: Carex canescens L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/php-whp-4te
title: Cynoglossum creticum Mill.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/509-ckk-3k9
title: Salvia verbenaca L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/7nd-cfw-dnb
title: Medicago disciformis DC.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.13140/rg.2.2.13007.38563
title: Online herbarium of Kerala Forest Research Institute, India [KFRI Herbarium]
DOI: 10.13140/rg.2.2.27687.44963
title: "fincrawling" Symphurus insularis - film 2
DOI: 10.3535/5r4-p7j-y53
title: Plantago lagopus L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.