cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5930857.v1
title: Epidemiology of fungal keratitis treated with penetrating keratoplasty by means of histopathologic findings

description: ABSTRACT Objective: To study, by means of histopathological examination, the epidemiology of fungal keratitis treated with penetrating keratoplasty therapy, emphasizing the presence of previous ocular surgery. Methods: Initially, we made an observational and cross-sectional study of corneal buttons from penetrating keratoplasty in the 2006-2015 period sent for histopathological examination at the Hospital Geral de Fortaleza Eye Bank.Tissues were stained with hematoxylin-eosin, PAS or Grocott, and examined with an optical microscope. We selected the cases with histopathological diagnosis of fungal keratitis. After the selection, we carried out a review of records seeking for age and sex of patients, date(s) of the graft(s) made to treat fungal keratitis, preoperative clinical diagnosis, presence/type of earlier and/or subsequent surgeries.We included 62 corneal buttons from 55 patients. Results: Most patients were male. Only 7 (11.29%) cases had recurrence of the surgically treated infection. 10 (16.13%) cases had eye surgery prior to fungal keratitis treated by transplant. No cases had fungal keratitis as preoperative clinical diagnosis.The main form of fungus in histopathological examination was isolated yeast form, followed by the yeast form associated with the filamentous form.The predominant aspect of Descemet's membrane was free of fungus. Conclusion: We demonstrated the healing potential of fungal keratitis when treated with penetrating therapeutic keratoplasty and the possible association of previous eye surgery factor for the development of these infections. Characteristics of histopathological examination have been approached differently from other studies that mostly specify only the microbiological examination. The difficulty in preoperative clinical diagnosis was highlighted, which may have contributed to the evolution of the cases studied for surgical treatment.
DOI: 10.5281/zenodo.6594378
title: MIDOG challenge npz files for Oneat

description: MIDOG challenge dataset converted to Oneat compatiable npz files Computational support provided by Jean Zay dynamic access grant: AD011013396, oneat model training and evaluation was performed on Jean Zay compute nodes
DOI: 10.6084/m9.figshare.6007919
title: Clinical analysis therapy and tomographic parameters of patients diagnosed with keratoconus attended at Fundação Hilton Rocha

description: Abstract Objective: Analyze clinical data, therapy and tomographic parameters of patients attended at Fundação Hilton Rocha. Methods: This essay is a retrospective study based on a random sample of 150 patients submitted to cornea tomography and previous segment (Pentacam – Oculus, Wetzlar, Germany) at Fundação Hilton Rocha in the year 2015. The patients were classified as carriers or suspects of keratoconus through the following parameters: pachymetry, anterior and posterior central elevation, Ambrosio Relational Thinnest (ART), value of D and keratometry. After the selection an analysis of the medical records was done, followed by harvest of clinical and therapeutical data of the patients. The data was put on table and then analyzed. Results: From the numbers of the patients diagnosed with carriers of keratoconus, 23% had 6 altered parameters, and 10% were classified with only 1 altered parameter. The ART index was the one that suffered the largest change (83%) on the keratoconus carriers. After analysis of clinical and therapeutical data, 76.8% of patients showed better or more of 20/60 degree of visual acuity, and 19% mentioned signs of atopy, 90% of the patients were using only corrective lenses as treatment (glasses and contact lenses). Conclusion: The use of tomographic indexes for the diagnosis of keratoconus has been increasing the sensibility and specificity of the triage of carriers of this ecstasy, allowing an earlier and better diagnosis of this medical condition.
DOI: 10.6084/m9.figshare.6007919.v1
title: Clinical analysis therapy and tomographic parameters of patients diagnosed with keratoconus attended at Fundação Hilton Rocha

description: Abstract Objective: Analyze clinical data, therapy and tomographic parameters of patients attended at Fundação Hilton Rocha. Methods: This essay is a retrospective study based on a random sample of 150 patients submitted to cornea tomography and previous segment (Pentacam – Oculus, Wetzlar, Germany) at Fundação Hilton Rocha in the year 2015. The patients were classified as carriers or suspects of keratoconus through the following parameters: pachymetry, anterior and posterior central elevation, Ambrosio Relational Thinnest (ART), value of D and keratometry. After the selection an analysis of the medical records was done, followed by harvest of clinical and therapeutical data of the patients. The data was put on table and then analyzed. Results: From the numbers of the patients diagnosed with carriers of keratoconus, 23% had 6 altered parameters, and 10% were classified with only 1 altered parameter. The ART index was the one that suffered the largest change (83%) on the keratoconus carriers. After analysis of clinical and therapeutical data, 76.8% of patients showed better or more of 20/60 degree of visual acuity, and 19% mentioned signs of atopy, 90% of the patients were using only corrective lenses as treatment (glasses and contact lenses). Conclusion: The use of tomographic indexes for the diagnosis of keratoconus has been increasing the sensibility and specificity of the triage of carriers of this ecstasy, allowing an earlier and better diagnosis of this medical condition.
DOI: 10.6084/m9.figshare.6008270.v1
title: Analysis of intraocular pressure variation after intravitreal injection of ranibizumab

description: Abstract Objective: Treatment with anti-angiogenic drugs is one of the most widely used modalities of treatment of macular edema related conditions. Intravitreal injection of a VEGF-A inhibitor is highly effective, but is related to adverse effects such as increased intraocular pressure. The objective of this study was to evaluate intraocular pressure (IOP) variation in patients who underwent intravitreal injections of ranibizumab, variation according to phakic/aphakic and history of previous injections. Methods: This was a cross-sectional observational study. All patients submitted to intravitreal injections with diagnosis of exudative age-related macular degeneration, retinal central vein occlusion with macular ede-ma, or diabetic macular edema were included. The IOP was measured before the injection, immediately after and 30 minutes after the injection with a portable tonometer. Results: 143 intravitreal injections were performed, with 96 injec-tions performed in 55 participants. The comparison between IOP before and 30 minutes after intravitreal injection showed to be statistically significant with higher than initial IOP (p &lt;0.0001) in patients with diabetic macular edema. Phakic and aphakic patients did not show significant differences regarding IOP variation. When only those participants who had received previous injections were analyzed, no significant variation was found. Conclusion: We conclude in this study that there is a significant difference between intraocular pressure before and 30 minutes after intravitreal injection of ranibizumab in patients with diabetic macular edema, showing that this period of time was not sufficient for regression of IOP at the pre-injection value . We did not find significant differences between other groups, comparing phakic and aphakic patients, nor in patients who had received previous injections.
DOI: 10.6084/m9.figshare.6008270
title: Analysis of intraocular pressure variation after intravitreal injection of ranibizumab

description: Abstract Objective: Treatment with anti-angiogenic drugs is one of the most widely used modalities of treatment of macular edema related conditions. Intravitreal injection of a VEGF-A inhibitor is highly effective, but is related to adverse effects such as increased intraocular pressure. The objective of this study was to evaluate intraocular pressure (IOP) variation in patients who underwent intravitreal injections of ranibizumab, variation according to phakic/aphakic and history of previous injections. Methods: This was a cross-sectional observational study. All patients submitted to intravitreal injections with diagnosis of exudative age-related macular degeneration, retinal central vein occlusion with macular ede-ma, or diabetic macular edema were included. The IOP was measured before the injection, immediately after and 30 minutes after the injection with a portable tonometer. Results: 143 intravitreal injections were performed, with 96 injec-tions performed in 55 participants. The comparison between IOP before and 30 minutes after intravitreal injection showed to be statistically significant with higher than initial IOP (p &lt;0.0001) in patients with diabetic macular edema. Phakic and aphakic patients did not show significant differences regarding IOP variation. When only those participants who had received previous injections were analyzed, no significant variation was found. Conclusion: We conclude in this study that there is a significant difference between intraocular pressure before and 30 minutes after intravitreal injection of ranibizumab in patients with diabetic macular edema, showing that this period of time was not sufficient for regression of IOP at the pre-injection value . We did not find significant differences between other groups, comparing phakic and aphakic patients, nor in patients who had received previous injections.
DOI: 10.6084/m9.figshare.6007841
title: Simultaneous bilateral and unilateral recurrent posterior scleritis

description: Abstract Posterior scleritis is an ocular inflammatory disease that affects the sclera e whose diagnosis is difficult. The main clinical manifestations are worsening of visual quality, ocular pain and finding in the posterior segment, such as serous retinal detachment, choroidal folds, optic disc edema and sclera thickening. We should award for systemic findings, because it is often accompanied by rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and infections, such as syphilis and tuberculosis.This paper aims to describe two cases: one patient with simultaneous bilateral posterior scleritis without systemic alterations correlated with the disease. Bilateral presentation is uncommon in this pathology; and another case of recurrent unilateral anterior and posterior scleritis.
DOI: 10.6084/m9.figshare.6007841.v1
title: Simultaneous bilateral and unilateral recurrent posterior scleritis

description: Abstract Posterior scleritis is an ocular inflammatory disease that affects the sclera e whose diagnosis is difficult. The main clinical manifestations are worsening of visual quality, ocular pain and finding in the posterior segment, such as serous retinal detachment, choroidal folds, optic disc edema and sclera thickening. We should award for systemic findings, because it is often accompanied by rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and infections, such as syphilis and tuberculosis.This paper aims to describe two cases: one patient with simultaneous bilateral posterior scleritis without systemic alterations correlated with the disease. Bilateral presentation is uncommon in this pathology; and another case of recurrent unilateral anterior and posterior scleritis.
DOI: 10.6084/m9.figshare.6388238
title: Decrease of myopia progression with 0.025% atropine

description: Abstract Purpose: To demonstrate the efficacy of 0.025% atropine eyedrops in myopic children in Brazil for decreasing myopia progression Methods: This was a prospective study with 60 children from Hospital Geral Universitário and Oftalmocenter Santa Rosa in Cuiabá, MT, Brazil, aged between 6 to 12 years, with spherical equivalent refractive error of -1.00 to -6.00 diopters (D) and astigmatism of -1.00 D or smaller. They underwent a complete ophthalmological examination, corneal topography and optical biometry. Children were assigned into two groups: group 1 used 0.025% atropine drop, once-nightly dosing, and it was prescribed total refraction in anti-reflective coating lens; and group 2 was prescribed just total refraction. A new evaluation was conducted 2 years after that. Paired student’s t-test was used to compare refractions, axial length and keratometry which were measured in an initial exam and after a two-year follow-up. Results: Of the 60 children, the 30 in group 1 had an age mean and SD 8.21 +/- 1.72, and of the control group were 8.17 +/- 1.73 years. Fourteen (46,66%) and 16 (53,33%) were male, respectively. Myopic progression was significantly lower in group 1 (-0.43 +/- 0.19 D) than in group 2 (-1.24 +/- 0.37 D) and axial length increase was also significantly smaller in group 1(0.19 +/- 0.09 mm) than in group 2 (0.48 +/- 0.12 mm). There were no significant statistical differences regarding keratometry between groups. Conclusions: Low dose atropine eyedrops were effective in decreasing myopia progression in 65% of this population studied for 2 years. Furthermore, a larger scale randomized controlled study with longer follow-up seems warranted.
DOI: 10.6084/m9.figshare.6388238.v1
title: Decrease of myopia progression with 0.025% atropine

description: Abstract Purpose: To demonstrate the efficacy of 0.025% atropine eyedrops in myopic children in Brazil for decreasing myopia progression Methods: This was a prospective study with 60 children from Hospital Geral Universitário and Oftalmocenter Santa Rosa in Cuiabá, MT, Brazil, aged between 6 to 12 years, with spherical equivalent refractive error of -1.00 to -6.00 diopters (D) and astigmatism of -1.00 D or smaller. They underwent a complete ophthalmological examination, corneal topography and optical biometry. Children were assigned into two groups: group 1 used 0.025% atropine drop, once-nightly dosing, and it was prescribed total refraction in anti-reflective coating lens; and group 2 was prescribed just total refraction. A new evaluation was conducted 2 years after that. Paired student’s t-test was used to compare refractions, axial length and keratometry which were measured in an initial exam and after a two-year follow-up. Results: Of the 60 children, the 30 in group 1 had an age mean and SD 8.21 +/- 1.72, and of the control group were 8.17 +/- 1.73 years. Fourteen (46,66%) and 16 (53,33%) were male, respectively. Myopic progression was significantly lower in group 1 (-0.43 +/- 0.19 D) than in group 2 (-1.24 +/- 0.37 D) and axial length increase was also significantly smaller in group 1(0.19 +/- 0.09 mm) than in group 2 (0.48 +/- 0.12 mm). There were no significant statistical differences regarding keratometry between groups. Conclusions: Low dose atropine eyedrops were effective in decreasing myopia progression in 65% of this population studied for 2 years. Furthermore, a larger scale randomized controlled study with longer follow-up seems warranted.
DOI: 10.6084/m9.figshare.7273229
title: Corneal Astigmatism in cataract surgery candidates

description: Abstract Purpose: To report the prevalence and analyse corneal astigmatism patterns in cataract surgery candidates. Methods: Researchers examined 2136 eyes from 1204 patients for cataract surgery from 1 January to 31 December 2016. All the candidates were evaluated with partial coherence interferometry (IOLMaster). The results were analysed statistically in relation to qualitative and quantitative variables. Results: The mean age of the patients was 71.9 years with a female predominance. Mean corneal astigmatism was 1.0 dioptre (D). Against the rule (ATR) astigmatism increased with age. Women presented with steeper corneas than men. In those patients who had both eyes measured, we found strong correlations between amount of right and left eye astigmatism, axis and keratometry. Overall, 39% of the eyes had corneal astigmatism &gt; 1.00 D and 19% &gt;1.50 D. Conclusions: A significant percentage of our population presents with corneal astigmatism &gt; 1.00 D with a shift from WTR (with the rule) to ATR with increasing age. Our findings, in a population that has never been described before, will be helpful to surgeons to enhance surgical techniques, patients to improve visual outcomes, IOL (intraocular lens) manufacturers to make better designs and health agents to optimise resources.
DOI: 10.6084/m9.figshare.7273229.v1
title: Corneal Astigmatism in cataract surgery candidates

description: Abstract Purpose: To report the prevalence and analyse corneal astigmatism patterns in cataract surgery candidates. Methods: Researchers examined 2136 eyes from 1204 patients for cataract surgery from 1 January to 31 December 2016. All the candidates were evaluated with partial coherence interferometry (IOLMaster). The results were analysed statistically in relation to qualitative and quantitative variables. Results: The mean age of the patients was 71.9 years with a female predominance. Mean corneal astigmatism was 1.0 dioptre (D). Against the rule (ATR) astigmatism increased with age. Women presented with steeper corneas than men. In those patients who had both eyes measured, we found strong correlations between amount of right and left eye astigmatism, axis and keratometry. Overall, 39% of the eyes had corneal astigmatism &gt; 1.00 D and 19% &gt;1.50 D. Conclusions: A significant percentage of our population presents with corneal astigmatism &gt; 1.00 D with a shift from WTR (with the rule) to ATR with increasing age. Our findings, in a population that has never been described before, will be helpful to surgeons to enhance surgical techniques, patients to improve visual outcomes, IOL (intraocular lens) manufacturers to make better designs and health agents to optimise resources.
DOI: 10.6084/m9.figshare.7273565
title: Coats disease associated with vasoproliferative tumor treated with cryotherapy and intravitreal injections of triamcinolone

description: Abstract Report of a case of Coats disease associated with retinal vasoproliferative tumor in a young female patient with two peripheral vascularized tumors and lipid exudation involving the macula and peripapillary region with serous retinal detachment areas and pre-papillary fibrous proliferation. The proposed and performed treatment was the intravitreal injection of triamcinolone acetonide to decrease the tumor exudation, followed by photocoagulation of the peripheral areas of telangiectasia without subretinal fluid and cryotherapy of the tumors. Despite that this is a rare and difficult to treat combination, in this case report, success was obtained in receding the tumor masses and reapplying the retina, leading to anatomic and visual stabilization.
DOI: 10.6084/m9.figshare.7273565.v1
title: Coats disease associated with vasoproliferative tumor treated with cryotherapy and intravitreal injections of triamcinolone

description: Abstract Report of a case of Coats disease associated with retinal vasoproliferative tumor in a young female patient with two peripheral vascularized tumors and lipid exudation involving the macula and peripapillary region with serous retinal detachment areas and pre-papillary fibrous proliferation. The proposed and performed treatment was the intravitreal injection of triamcinolone acetonide to decrease the tumor exudation, followed by photocoagulation of the peripheral areas of telangiectasia without subretinal fluid and cryotherapy of the tumors. Despite that this is a rare and difficult to treat combination, in this case report, success was obtained in receding the tumor masses and reapplying the retina, leading to anatomic and visual stabilization.
DOI: 10.6084/m9.figshare.7273214
title: Sympathetic ophthalmia

description: Abstract To report the case of a patient with sympathetic ophthalmia (OS), with serous detachment of retinal documented by spectral domain optical coherence tomography (OCT), indocyanine green (ICG) and angiofluorecephography (AGF). The diagnosis was made in a routine consultation and clinical treatment was initiated.
DOI: 10.6084/m9.figshare.7273214.v1
title: Sympathetic ophthalmia

description: Abstract To report the case of a patient with sympathetic ophthalmia (OS), with serous detachment of retinal documented by spectral domain optical coherence tomography (OCT), indocyanine green (ICG) and angiofluorecephography (AGF). The diagnosis was made in a routine consultation and clinical treatment was initiated.
DOI: 10.6084/m9.figshare.7273562
title: Tolosa-Hunt Syndrome

description: Abstract We present a case study of Tolosa-Hunt syndrome, a rare idiopathic disease, that is characterized by painful ophthalmoplegia of strong intensity, generally affecting the third cranial nerve, and, less frequently, the fourth or the sixth cranial nerves. Usually, there is no visual impairment. The treatment is based on corticosteroids with satisfactory results in most cases although recurrences can occur at intervals from months to years. In our case, the patient presented sudden pain periorbital associated with cranial nerves involvement, which have an excellent outcome after treatment with corticosteroids, with no relapses until today.
DOI: 10.6084/m9.figshare.7273562.v1
title: Tolosa-Hunt Syndrome

description: Abstract We present a case study of Tolosa-Hunt syndrome, a rare idiopathic disease, that is characterized by painful ophthalmoplegia of strong intensity, generally affecting the third cranial nerve, and, less frequently, the fourth or the sixth cranial nerves. Usually, there is no visual impairment. The treatment is based on corticosteroids with satisfactory results in most cases although recurrences can occur at intervals from months to years. In our case, the patient presented sudden pain periorbital associated with cranial nerves involvement, which have an excellent outcome after treatment with corticosteroids, with no relapses until today.
DOI: 10.6084/m9.figshare.7273571
title: Periorbital presentation of IgG4 related disease

description: Abstract IgG4-Related Disease is an immunomediated condition that is characterized by the presence of inflammatory lesions associated with fibrosis and lymphoplasmacytic infiltration rich in positive IgG4 tissue plasmocytes, forming a spectrum of fibroproliferative diseases. The pathogenesis of IgG4-RD is still poorly understood and the treatment is empirical. We report the case of a 50-year-old man with yellow eyelid lesions associated with local edema, previously diagnosed as an allergic process, until biopsy with immunohistochemical study and serum IgG4 dosage revealed the hypothesis of IgG4 related disease. Treatment with corticoid and rituximab was initiated, showing stabilization of the condition, without presenting other clinical forms of the disease.
DOI: 10.6084/m9.figshare.7273571.v1
title: Periorbital presentation of IgG4 related disease

description: Abstract IgG4-Related Disease is an immunomediated condition that is characterized by the presence of inflammatory lesions associated with fibrosis and lymphoplasmacytic infiltration rich in positive IgG4 tissue plasmocytes, forming a spectrum of fibroproliferative diseases. The pathogenesis of IgG4-RD is still poorly understood and the treatment is empirical. We report the case of a 50-year-old man with yellow eyelid lesions associated with local edema, previously diagnosed as an allergic process, until biopsy with immunohistochemical study and serum IgG4 dosage revealed the hypothesis of IgG4 related disease. Treatment with corticoid and rituximab was initiated, showing stabilization of the condition, without presenting other clinical forms of the disease.