cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3886/e244321v1
title: Behavioral Risk Factors – Vision and Eye Health Surveillance

description: 2013-2022. This dataset is a de-identified summary table of vision and eye health data indicators from BRFSS, stratified by all available combinations of age group, race/ethnicity, sex, risk factor and state. BRFSS is a system of telephone surveys conducted by CDC that collect state data about U.S. residents regarding their health-related risk behaviors, chronic health conditions, and use of preventive services. BRFSS completes more than 400,000 adult interviews each year across 50 states, the District of Columbia, and three U.S. territories. BRFSS data for VEHSS includes one question from the core component related to Visual Function. Data were suppressed following NCHS standards. Data will be updated as it becomes available. Detailed information on VEHSS BRFSS analyses can be found on the VEHSS BRFSS webpage (link). General information about BRFSS can be found on the BRFSS website (https://www.cdc.gov/brfss). The VEHSS BRFSS dataset was last updated in November 2019.
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description: (Downloaded 1/16/2026)
DOI: 10.5281/zenodo.18282410
title: Hypericum L. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282409
title: Hypericum L. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282418
title: Hypericum brasiliense Choisy. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282419
title: Hypericum brasiliense Choisy. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282397
title: CONTEMPORARY CHALLENGES IN MANAGERIAL DECISION-MAKING IN SMALL BUSINESSES

description: Managerial decision-making in small businesses has become increasingly complex in the context of rapid economic, technological, and social change. Unlike large corporations, small enterprises operate with limited resources, higher vulnerability to external shocks, and a strong dependence on the personal competencies of owners and managers. This paper explores contemporary problems in managerial decision-making in small businesses from an international and theoretical perspective. It examines how uncertainty, information asymmetry, digital transformation, human capital constraints, financial limitations, and institutional environments shape decision-making processes in small firms. Particular attention is given to the role of intuition versus analytical approaches, the impact of digital tools on decision quality, and the psychological and behavioral factors influencing small business managers.
DOI: 10.5281/zenodo.10808193
title: Development of the First Stroke Leader in Negative Cloud-to-Ground Lightning during Thunderstorm Evolution

description: The files contain the complete radar and lightning datasets of the 12 thunderstorms used in the analysis presented in “Development of the First Stroke Leader in Negative Cloud-to-Ground Lightning during Thunderstorm Evolution”
DOI: 10.5281/zenodo.16895968
title: Development of the First Stroke Leader in Negative Cloud-to-Ground Lightning during Thunderstorm Evolution

description: The files contain the complete radar and lightning datasets of the 12 thunderstorms used in the analysis presented in “Development of the First Stroke Leader in Negative Cloud-to-Ground Lightning during Thunderstorm Evolution”
DOI: 10.5281/zenodo.18282396
title: CONTEMPORARY CHALLENGES IN MANAGERIAL DECISION-MAKING IN SMALL BUSINESSES

description: Managerial decision-making in small businesses has become increasingly complex in the context of rapid economic, technological, and social change. Unlike large corporations, small enterprises operate with limited resources, higher vulnerability to external shocks, and a strong dependence on the personal competencies of owners and managers. This paper explores contemporary problems in managerial decision-making in small businesses from an international and theoretical perspective. It examines how uncertainty, information asymmetry, digital transformation, human capital constraints, financial limitations, and institutional environments shape decision-making processes in small firms. Particular attention is given to the role of intuition versus analytical approaches, the impact of digital tools on decision quality, and the psychological and behavioral factors influencing small business managers.
DOI: 10.3886/e244322
title: DASH – School Health Profiles (Profiles)

description: 2022 School Health Profiles (Profiles) Dataset. Profiles is a system of surveys assessing school health policies and practices in states, school districts, territories, and tribes. Profiles surveys are conducted biennially by education and health agencies among middle and high school principals and lead health education teachers. Profiles monitors the current status of school health education requirements and content, physical education and physical activity, practices related to bullying and sexual harassment, school health policies related to tobacco-use prevention and nutrition, school-based health and mental health services, family engagement and community involvement, and school health coordination.
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description: (Downloaded 1/16/2026)
DOI: 10.3886/e244322v1
title: DASH – School Health Profiles (Profiles)

description: 2022 School Health Profiles (Profiles) Dataset. Profiles is a system of surveys assessing school health policies and practices in states, school districts, territories, and tribes. Profiles surveys are conducted biennially by education and health agencies among middle and high school principals and lead health education teachers. Profiles monitors the current status of school health education requirements and content, physical education and physical activity, practices related to bullying and sexual harassment, school health policies related to tobacco-use prevention and nutrition, school-based health and mental health services, family engagement and community involvement, and school health coordination.
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description: (Downloaded 1/16/2026)
DOI: 10.6084/m9.figshare.31081537
title: Supplementary Material for: The Association of Dietary Patterns with Age-Related Macular Degeneration in a Multi-Ethnic Older Singaporean Population

description: Introduction: The associations of dietary patterns and age-related macular degeneration (AMD) have been reported using mostly Western and Japanese populations and evidence in multi-ethnic Asian populations, with potentially different dietary patterns, is lacking. In this study, we aimed to identify dietary patterns in a multi-ethnic older Singaporean population and examine their associations with AMD.
Methods: This was a cross-sectional analysis of the Population Health and Eye Disease Profile in Elderly Singaporeans (PIONEER) study. Dietary intake was assessed using a 110-item interviewer-administered food frequency questionnaire validated in a Singaporean population. Presence and stage of AMD were categorized using fundus photographs and an established AMD classification. Dietary patterns were generated by applying exploratory factor analysis, and their associations with presence of AMD and stage of AMD were evaluated using adjusted logistic regression models and adjusted multinomial logistic regression models, respectively.
Results: Of 1480 Chinese, Malay, and Indian individuals aged≥60 years (mean 71.3±7.7), age-standardized prevalence of any, early, and late AMD were 7.1%, 4.8%, and 2.2%. Three dietary patterns were generated: “Snacks, Fried Foods, and Refined Carbohydrates”; “Poultry, Meat and Fish”; and “Wholemeal Bread, Legumes and Nuts”. After adjusting for covariates, higher “Snacks, Fried Foods, and Refined Carbohydrates” pattern scores was associated with higher odds of any AMD (OR=1.41, 95%CI: 1.02-1.96) and early AMD (OR=1.63, 95%CI: 1.12-2.37). “Snacks, Fried Foods, and Refined Carbohydrates” pattern scores in the highest quartile were associated with higher odds of any AMD (OR=2.18, 95%CI: 1.01-4.72), compared to the lowest quartile.
Conclusion: Only the “Snacks, Fried Foods, and Refined Carbohydrates” pattern was associated with AMD in this multi-ethnic older Singaporean population. These findings may inform the development of dietary guidelines in Singapore for more targeted AMD management, although prospective, longitudinal data are needed.
DOI: 10.6084/m9.figshare.31081537.v1
title: Supplementary Material for: The Association of Dietary Patterns with Age-Related Macular Degeneration in a Multi-Ethnic Older Singaporean Population

description: Introduction: The associations of dietary patterns and age-related macular degeneration (AMD) have been reported using mostly Western and Japanese populations and evidence in multi-ethnic Asian populations, with potentially different dietary patterns, is lacking. In this study, we aimed to identify dietary patterns in a multi-ethnic older Singaporean population and examine their associations with AMD.
Methods: This was a cross-sectional analysis of the Population Health and Eye Disease Profile in Elderly Singaporeans (PIONEER) study. Dietary intake was assessed using a 110-item interviewer-administered food frequency questionnaire validated in a Singaporean population. Presence and stage of AMD were categorized using fundus photographs and an established AMD classification. Dietary patterns were generated by applying exploratory factor analysis, and their associations with presence of AMD and stage of AMD were evaluated using adjusted logistic regression models and adjusted multinomial logistic regression models, respectively.
Results: Of 1480 Chinese, Malay, and Indian individuals aged≥60 years (mean 71.3±7.7), age-standardized prevalence of any, early, and late AMD were 7.1%, 4.8%, and 2.2%. Three dietary patterns were generated: “Snacks, Fried Foods, and Refined Carbohydrates”; “Poultry, Meat and Fish”; and “Wholemeal Bread, Legumes and Nuts”. After adjusting for covariates, higher “Snacks, Fried Foods, and Refined Carbohydrates” pattern scores was associated with higher odds of any AMD (OR=1.41, 95%CI: 1.02-1.96) and early AMD (OR=1.63, 95%CI: 1.12-2.37). “Snacks, Fried Foods, and Refined Carbohydrates” pattern scores in the highest quartile were associated with higher odds of any AMD (OR=2.18, 95%CI: 1.01-4.72), compared to the lowest quartile.
Conclusion: Only the “Snacks, Fried Foods, and Refined Carbohydrates” pattern was associated with AMD in this multi-ethnic older Singaporean population. These findings may inform the development of dietary guidelines in Singapore for more targeted AMD management, although prospective, longitudinal data are needed.
DOI: 10.6084/m9.figshare.31081540
title: Supplementary Material for: Early neurotoxicity following a single dose of brentuximab in a patient with Epstein bar virus driven lymphoma: A Case Report

description: Background:
Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) present unique challenges in immunocompromised patients. Neurotoxic complications typically arise after prolonged exposure and tend to manifest as peripheral neuropathy. This case describes acute encephalopathy shortly after a brief course, an uncommon and severe adverse effect. 
Case Report:
We describe a 17-year-old Hispanic male with EBV-associated LPD in the setting of complex autoimmune vasculitis and immunosuppression. Disease was unresponsive to multiple therapies including rituximab and chemotherapy, but eventually responded to a course of SMILE (steroid-dexamethasone, methotrexate, ifosfamide, L-asparaginase, etoposide). Brentuximab vedotin maintenance was initiated to secure remission. However, 7 days post-initiation, he developed culture-negative sepsis which progressed to acute encephalopathy and multiorgan failure. Infectious work-up along with Neurological evaluation, including imaging and cerebrospinal fluid analysis, did not identify an alternative etiology.
Conclusion:
This case highlights a rare instance of early brentuximab vedotin-induced encephalopathy and underscores the need for close neurological monitoring in high-risk patients.
DOI: 10.5281/zenodo.18282430
title: LINF_310023900

description: Zinc finger (MYND-type)-containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.6084/m9.figshare.31081540.v1
title: Supplementary Material for: Early neurotoxicity following a single dose of brentuximab in a patient with Epstein bar virus driven lymphoma: A Case Report

description: Background:
Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) present unique challenges in immunocompromised patients. Neurotoxic complications typically arise after prolonged exposure and tend to manifest as peripheral neuropathy. This case describes acute encephalopathy shortly after a brief course, an uncommon and severe adverse effect. 
Case Report:
We describe a 17-year-old Hispanic male with EBV-associated LPD in the setting of complex autoimmune vasculitis and immunosuppression. Disease was unresponsive to multiple therapies including rituximab and chemotherapy, but eventually responded to a course of SMILE (steroid-dexamethasone, methotrexate, ifosfamide, L-asparaginase, etoposide). Brentuximab vedotin maintenance was initiated to secure remission. However, 7 days post-initiation, he developed culture-negative sepsis which progressed to acute encephalopathy and multiorgan failure. Infectious work-up along with Neurological evaluation, including imaging and cerebrospinal fluid analysis, did not identify an alternative etiology.
Conclusion:
This case highlights a rare instance of early brentuximab vedotin-induced encephalopathy and underscores the need for close neurological monitoring in high-risk patients.
DOI: 10.5281/zenodo.18282429
title: LINF_310023900

description: Zinc finger (MYND-type)-containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.6084/m9.figshare.31081543
title: Supplementary Material for: UFT-Induced Sinusoidal Obstruction Syndrome as a Suspected Cause of Liver Cirrhosis during Adjuvant Chemotherapy for Lung Adenocarcinoma: A Case Report

description: Introduction: Tegafur/uracil (UFT) is a widely used oral adjuvant chemotherapy for non-small cell lung cancer. Severe hepatic toxicity is rare, and sinusoidal obstruction syndrome (SOS) has not been well characterized in this setting. [1–3].
Case Presentation: A 76-year-old man underwent thoracoscopic middle lobectomy for stage IA3 papillary adenocarcinoma of the right lung. Adjuvant UFT therapy was started 2 months postoperatively. Although liver enzymes were mildly elevated, treatment was continued. After 11 months of UFT, he developed abdominal distension and bilateral leg edema. Laboratory testing revealed severe hypoalbuminemia, coagulopathy, and marked increases in M2BPGi and hyaluronic acid. Viral hepatitis, autoimmune disease, metabolic liver disease, and cardiogenic hepatopathy were excluded. Contrast-enhanced CT showed pronounced hepatic atrophy, moderate ascites, and heterogeneous delayed-phase enhancement consistent with sinusoidal perfusion abnormalities. Because of ascites and coagulopathy, biopsy was contraindicated. The constellation of imaging, clinical course, and laboratory findings indicated drug-induced sinusoidal injury most consistent with UFT-related SOS. UFT was discontinued, and supportive management was initiated, including albumin, diuretics, and ursodeoxycholic acid. Liver function gradually improved, ascites resolved, and follow-up CT demonstrated partial restoration of hepatic volume over 6 months.
Conclusion: This case represents the first reported instance in which UFT-induced hepatic injury was clinically, biochemically, and radiologically demonstrated to be consistent with sinusoidal obstruction syndrome. It highlights a rare but serious hepatic complication of UFT and underscores that careful monitoring of fibrosis markers and radiologic findings—not only liver enzymes—is essential for early detection of drug-induced sinusoidal obstruction syndrome during prolonged adjuvant chemotherapy.
DOI: 10.6084/m9.figshare.31081543.v1
title: Supplementary Material for: UFT-Induced Sinusoidal Obstruction Syndrome as a Suspected Cause of Liver Cirrhosis during Adjuvant Chemotherapy for Lung Adenocarcinoma: A Case Report

description: Introduction: Tegafur/uracil (UFT) is a widely used oral adjuvant chemotherapy for non-small cell lung cancer. Severe hepatic toxicity is rare, and sinusoidal obstruction syndrome (SOS) has not been well characterized in this setting. [1–3].
Case Presentation: A 76-year-old man underwent thoracoscopic middle lobectomy for stage IA3 papillary adenocarcinoma of the right lung. Adjuvant UFT therapy was started 2 months postoperatively. Although liver enzymes were mildly elevated, treatment was continued. After 11 months of UFT, he developed abdominal distension and bilateral leg edema. Laboratory testing revealed severe hypoalbuminemia, coagulopathy, and marked increases in M2BPGi and hyaluronic acid. Viral hepatitis, autoimmune disease, metabolic liver disease, and cardiogenic hepatopathy were excluded. Contrast-enhanced CT showed pronounced hepatic atrophy, moderate ascites, and heterogeneous delayed-phase enhancement consistent with sinusoidal perfusion abnormalities. Because of ascites and coagulopathy, biopsy was contraindicated. The constellation of imaging, clinical course, and laboratory findings indicated drug-induced sinusoidal injury most consistent with UFT-related SOS. UFT was discontinued, and supportive management was initiated, including albumin, diuretics, and ursodeoxycholic acid. Liver function gradually improved, ascites resolved, and follow-up CT demonstrated partial restoration of hepatic volume over 6 months.
Conclusion: This case represents the first reported instance in which UFT-induced hepatic injury was clinically, biochemically, and radiologically demonstrated to be consistent with sinusoidal obstruction syndrome. It highlights a rare but serious hepatic complication of UFT and underscores that careful monitoring of fibrosis markers and radiologic findings—not only liver enzymes—is essential for early detection of drug-induced sinusoidal obstruction syndrome during prolonged adjuvant chemotherapy.
DOI: 10.6084/m9.figshare.31081546
title: Supplementary Material for: Vulvar metastasis from breast cancer treated with abemaciclib plus fulvestrant: a case report

description: Abstract

Introduction
Breast cancer is the most common malignant tumor in women, affecting approximately 1 in 9 
women worldwide. In contrast, vulvar cancer remains rare, accounting for &lt;1% of all cancers among women. Metastatic vulvar tumors are even rarer, constituting only 5 to 8% of all vulvar cancers. In some cases, breast cancer may metastasize to the vulva or vulvar tumors can arise from ectopic breast tissue. 

Case Report
We report the case of a 78-year-old woman with vulvar metastasis of breast origin occurring 17 years after the diagnosis of primary breast cancer. The recurrence was identified by a PET scan concurrent with the patient reporting episodes of vaginal bleeding. Diagnosis was confirmed by clinical examination and biopsy. The proposed treatment was combined cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor abemaciclib and anti-estrogen agent fulvestrant. The patient demonstrated a good response, with a favorable clinical outcome as she is still in complete remission.

Conclusion
This case underscores the importance of long-term follow-up of hormone-sensitive breast cancer, including thorough clinical examinations. To the best of our knowledge, this is the first reported case of vulvar metastasis from breast cancer that was successfully treated with the combination of abemaciclib and fulvestrant, leading to a complete response. The use of CDK4/6 inhibitors for the treatment of vulvar metastases of breast origin represents a significant advance, offering a less invasive and potentially more effective alternative to current treatment protocols.
DOI: 10.6084/m9.figshare.31081546.v1
title: Supplementary Material for: Vulvar metastasis from breast cancer treated with abemaciclib plus fulvestrant: a case report

description: Abstract

Introduction
Breast cancer is the most common malignant tumor in women, affecting approximately 1 in 9 
women worldwide. In contrast, vulvar cancer remains rare, accounting for &lt;1% of all cancers among women. Metastatic vulvar tumors are even rarer, constituting only 5 to 8% of all vulvar cancers. In some cases, breast cancer may metastasize to the vulva or vulvar tumors can arise from ectopic breast tissue. 

Case Report
We report the case of a 78-year-old woman with vulvar metastasis of breast origin occurring 17 years after the diagnosis of primary breast cancer. The recurrence was identified by a PET scan concurrent with the patient reporting episodes of vaginal bleeding. Diagnosis was confirmed by clinical examination and biopsy. The proposed treatment was combined cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor abemaciclib and anti-estrogen agent fulvestrant. The patient demonstrated a good response, with a favorable clinical outcome as she is still in complete remission.

Conclusion
This case underscores the importance of long-term follow-up of hormone-sensitive breast cancer, including thorough clinical examinations. To the best of our knowledge, this is the first reported case of vulvar metastasis from breast cancer that was successfully treated with the combination of abemaciclib and fulvestrant, leading to a complete response. The use of CDK4/6 inhibitors for the treatment of vulvar metastases of breast origin represents a significant advance, offering a less invasive and potentially more effective alternative to current treatment protocols.
DOI: 10.5281/zenodo.18282451
title: Hypericum caprifoliatum Cham. & Schltdl. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282452
title: Hypericum caprifoliatum Cham. & Schltdl. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282458
title: Hypericum carinatum Griseb. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48
DOI: 10.5281/zenodo.18282459
title: Hypericum carinatum Griseb. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:48