cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14267540.v1
title: Supplementary Material for: Triflusal in Patients with Acute Coronary Syndrome and Acetylsalicylic Acid Hypersensitivity

description: <b><i>Background:</i></b> Acetylsalicylic acid hypersensitivity (ASAH) limits therapeutic options in patients with acute coronary syndrome (ACS), who benefit from dual antiplatelet therapy (DAPT), especially when undergoing stent implantation. Our aim was to evaluate the safety and efficacy of triflusal in patients with ACS and ASAH. <b><i>Methods and Results:</i></b> Two-center retrospective study of patients diagnosed with ACS and ASAH from January 1, 2000, to May 1, 2020. Sixty-six patients were treated with triflusal. ASAH was confirmed with tests in 15 patients (22.7%). Forty-nine patients (74.2%) presented history of other drug allergies. Fifty-nine patients (89.4%) underwent stent implantation. DAPT was prescribed for ≥12 months in 54 patients. No adverse reactions to triflusal were reported. During a median follow-up of 5.12 years [IQR 2.7–9.9], rate of cardiovascular (CV) mortality was 6.1%, nonfatal myocardial infarction 12.1%, and ischemic stroke 4.5%. No cases of definite stent thrombosis occurred. Bleeding Academic Research Consortium grade ≥2 was observed in 3 patients during follow-up. <b><i>Conclusion:</i></b> In this series of patients presenting with ACS and ASA hypersensitivity, triflusal showed good tolerability and was associated with a low rate of CV and bleeding events.
DOI: 10.5281/zenodo.3906705
title: How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: an example in non-target plants

description: Raw data sets (.txt format) for the seven case studies in the paper entitled "How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: an example in non-target plants" submitted to PLOS One in July 2020.
description: This research aims to account for the uncertainty on 50% effective rates (ER50) in species sensitivity distribution (SSD) analyses and to study how including this uncertainty may influence the 5% Hazard Rate (HR5) estimation. We explored various endpoints (survival, emergence, shoot dry weight) for non-target plants from seven standard greenhouse studies that used different experimental approaches (vegetative vigour vs. seedling emergence) and applied seven herbicides at different growth stages. Firstly for each endpoint of each study, a three-parameter log-logistic model was fitted to experimental toxicity test data for each species under a Bayesian framework to get a posterior probability distribution for ER50. Then in order to account for the uncertainty on the ER50, we explored two censoring criteria to censor ER50 taking the ER50 distribution and the range of tested rates into account. Based on dose-response fitting results and censoring criteria, we considered input ER50 values SSD analyses in three ways (only point estimates chosen as ER50 medians, interval-censored ER50 based on their 95% credible interval and censored ER50 according to one of the two criteria), by fitting a log-normal distribution under a frequentist framework to get the three corresponding HR5 estimates. We observed that SSD fitted reasonably well when there were at least six distinct ER50 values. By comparing the three SSD curves and the three HR5 estimates, we found that propagating the uncertainty from ER50 and including censored data into the SSD analysis often leads to smaller point estimates of HR5, which is more conservative in a risk assessment context. In addition, we recommend not to focus solely on the point estimate of the HR5, but also to look at the precision of this estimate as depicted by the 95% confidence interval.
DOI: 10.5281/zenodo.3906704
title: How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: an example in non-target plants

description: Raw data sets (.txt format) for the seven case studies in the paper entitled "How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: an example in non-target plants" submitted to PLOS One in July 2020.
description: This research aims to account for the uncertainty on 50% effective rates (ER50) in species sensitivity distribution (SSD) analyses and to study how including this uncertainty may influence the 5% Hazard Rate (HR5) estimation. We explored various endpoints (survival, emergence, shoot dry weight) for non-target plants from seven standard greenhouse studies that used different experimental approaches (vegetative vigour vs. seedling emergence) and applied seven herbicides at different growth stages. Firstly for each endpoint of each study, a three-parameter log-logistic model was fitted to experimental toxicity test data for each species under a Bayesian framework to get a posterior probability distribution for ER50. Then in order to account for the uncertainty on the ER50, we explored two censoring criteria to censor ER50 taking the ER50 distribution and the range of tested rates into account. Based on dose-response fitting results and censoring criteria, we considered input ER50 values SSD analyses in three ways (only point estimates chosen as ER50 medians, interval-censored ER50 based on their 95% credible interval and censored ER50 according to one of the two criteria), by fitting a log-normal distribution under a frequentist framework to get the three corresponding HR5 estimates. We observed that SSD fitted reasonably well when there were at least six distinct ER50 values. By comparing the three SSD curves and the three HR5 estimates, we found that propagating the uncertainty from ER50 and including censored data into the SSD analysis often leads to smaller point estimates of HR5, which is more conservative in a risk assessment context. In addition, we recommend not to focus solely on the point estimate of the HR5, but also to look at the precision of this estimate as depicted by the 95% confidence interval.
DOI: 10.25403/upresearchdata.13312217
title: Technology and the impact on client engagement for Financial Advisors in South Africa

description: Financial planning process and technology stack is a qualitative study was conducted with Financial Advisors regarding their financial planning processes and the technological tools they use in their financial planning process. The datasets include the videos of the interviews, as well as the consent forms that were signed by the interviewees.
DOI: 10.25403/upresearchdata.13312217.v1
title: Technology and the impact on client engagement for Financial Advisors in South Africa

description: Financial planning process and technology stack is a qualitative study was conducted with Financial Advisors regarding their financial planning processes and the technological tools they use in their financial planning process. The datasets include the videos of the interviews, as well as the consent forms that were signed by the interviewees.
DOI: 10.6084/m9.figshare.14267420
title: Supplementary Material for: Ankle-Brachial Index Is a Predictor of In-Hospital Functional Status but Not of Complications in Hospitalized Elderly Patients

description: <b><i>Introduction:</i></b> Atherosclerosis causes a chronic reduction of vascularization with consequent impairment of the performance of organs, like the brain or muscles, which determines the functional and cognitive decline of the elderly and their ability to respond to acute stressful condition. Therefore, our aim was to evaluate if ankle brachial index (ABI) could effectively be a determinant of in-hospital functional status and complications in elderly hospitalized patients. <b><i>Methods:</i></b> This is a monocentric cross-sectional study of 189 patients aged 65 years or older. The study was undertaken at the Internal Medicine ward of Niguarda Hospital in Milan. ABI (BOSO ABY-System 100) and in-hospital status (activities of daily living, ADL and instrumental activities of daily living, IADL) were collected on the second day of hospitalization. Complications (falls and delirium episodes) were also recorded during the whole hospitalization period. <b><i>Results:</i></b> The average age of patients was 79.3 ± 6.9 years. Among outcomes, only ADL (<i>r</i> = 0.192, <i>p</i> = 0.007) and IADL score (<i>r</i> = 0.200, <i>p</i> = 0.005) showed significant correlation with ABI. Moreover, during the subsequent logistic regression, ABI remained among the statistically significant determinants of both scores (β = 0.231, <i>p</i> = 0.013 and β = 0.314, <i>p</i> = 0.001, respectively). <b><i>Conclusions:</i></b> The main result of our study is the finding of ABI as a significant determinant of acute in-hospital functional impairment (evaluated as ADL and IADL scores). The continuous exposure of the brain and muscles to the reduced perfusions induced by vascular atherosclerosis, probably determined the reduced ability to respond to stressful conditions.
DOI: 10.6084/m9.figshare.14267420.v1
title: Supplementary Material for: Ankle-Brachial Index Is a Predictor of In-Hospital Functional Status but Not of Complications in Hospitalized Elderly Patients

description: <b><i>Introduction:</i></b> Atherosclerosis causes a chronic reduction of vascularization with consequent impairment of the performance of organs, like the brain or muscles, which determines the functional and cognitive decline of the elderly and their ability to respond to acute stressful condition. Therefore, our aim was to evaluate if ankle brachial index (ABI) could effectively be a determinant of in-hospital functional status and complications in elderly hospitalized patients. <b><i>Methods:</i></b> This is a monocentric cross-sectional study of 189 patients aged 65 years or older. The study was undertaken at the Internal Medicine ward of Niguarda Hospital in Milan. ABI (BOSO ABY-System 100) and in-hospital status (activities of daily living, ADL and instrumental activities of daily living, IADL) were collected on the second day of hospitalization. Complications (falls and delirium episodes) were also recorded during the whole hospitalization period. <b><i>Results:</i></b> The average age of patients was 79.3 ± 6.9 years. Among outcomes, only ADL (<i>r</i> = 0.192, <i>p</i> = 0.007) and IADL score (<i>r</i> = 0.200, <i>p</i> = 0.005) showed significant correlation with ABI. Moreover, during the subsequent logistic regression, ABI remained among the statistically significant determinants of both scores (β = 0.231, <i>p</i> = 0.013 and β = 0.314, <i>p</i> = 0.001, respectively). <b><i>Conclusions:</i></b> The main result of our study is the finding of ABI as a significant determinant of acute in-hospital functional impairment (evaluated as ADL and IADL scores). The continuous exposure of the brain and muscles to the reduced perfusions induced by vascular atherosclerosis, probably determined the reduced ability to respond to stressful conditions.
DOI: 10.6084/m9.figshare.14267471
title: Supplementary Material for: Prevalence and Risk Factors of Developing Fistula or Organ Perforation in Patients Treated with Lenvatinib for Radioiodine-Refractory Thyroid Cancer

description: <b><i>Introduction:</i></b> Tyrosine kinase inhibitors represent a better treatment in patients with radioiodine-refractory differentiated thyroid cancer (RAI-R DTC). Lenvatinib is usually well-tolerated, but sometimes, it is associated with serious and even life-threatening side effects. The aim of this study was to evaluate the prevalence of and the potential risk factors for fistula and/or organ perforation in RAI-R DTC patients treated with lenvatinib. <b><i>Methods:</i></b> This study included data from advanced and progressive RAI-R DTC patients treated with lenvatinib from February 2011 to February 2020 who were followed up at a single center. The clinical-pathological features and the biochemical and morphological results of the patients were collected at the time of starting lenvatinib and during the follow-up. <b><i>Results:</i></b> Fourteen of 95 (14.7%) locally advanced or metastatic RAI-R DTC patients treated with lenvatinib developed a fistula or organ perforation. Nine of 14 (64.3%) patients had tumor infiltration of the trachea, bronchus, esophagus, pleura, or bladder. Five of 14 (35.7%) had a bowel perforation, but only 2 had preexisting diverticulosis. Evaluation of the risk factors for developing a fistula or organ perforation showed that the presence of tumor infiltration and the tumor histology (papillary and poorly differentiated vs. follicular and Hurthle thyroid cancer) were significantly correlated with the development of a fistula or organ perforation (<i>p</i> = 0.003 and <i>p</i> = 0.02, respectively). In the subgroup of patients with tumor infiltration, we found that the papillary thyroid cancer histotype was the only potential predictor of fistula development. External beam radiation therapy (EBRT), the starting dose of lenvatinib, and the duration of treatment were not relevant for the development of fistula. <b><i>Conclusions:</i></b> In metastatic thyroid cancer patients treated with lenvatinib, the presence of tumor infiltration and histological type should be considered as potential risk factors for the development of fistula or organ perforation, although they do not represent an absolute contraindication. Although EBRT and the presence of diverticulosis were not significantly associated with the development of fistula and organ perforation, they should be regarded as potential additional reasons for the development of these complications. According to our findings, there is no reason to start lenvatinib at a lower daily dose when tumor infiltration is present.
DOI: 10.6084/m9.figshare.14267471.v1
title: Supplementary Material for: Prevalence and Risk Factors of Developing Fistula or Organ Perforation in Patients Treated with Lenvatinib for Radioiodine-Refractory Thyroid Cancer

description: <b><i>Introduction:</i></b> Tyrosine kinase inhibitors represent a better treatment in patients with radioiodine-refractory differentiated thyroid cancer (RAI-R DTC). Lenvatinib is usually well-tolerated, but sometimes, it is associated with serious and even life-threatening side effects. The aim of this study was to evaluate the prevalence of and the potential risk factors for fistula and/or organ perforation in RAI-R DTC patients treated with lenvatinib. <b><i>Methods:</i></b> This study included data from advanced and progressive RAI-R DTC patients treated with lenvatinib from February 2011 to February 2020 who were followed up at a single center. The clinical-pathological features and the biochemical and morphological results of the patients were collected at the time of starting lenvatinib and during the follow-up. <b><i>Results:</i></b> Fourteen of 95 (14.7%) locally advanced or metastatic RAI-R DTC patients treated with lenvatinib developed a fistula or organ perforation. Nine of 14 (64.3%) patients had tumor infiltration of the trachea, bronchus, esophagus, pleura, or bladder. Five of 14 (35.7%) had a bowel perforation, but only 2 had preexisting diverticulosis. Evaluation of the risk factors for developing a fistula or organ perforation showed that the presence of tumor infiltration and the tumor histology (papillary and poorly differentiated vs. follicular and Hurthle thyroid cancer) were significantly correlated with the development of a fistula or organ perforation (<i>p</i> = 0.003 and <i>p</i> = 0.02, respectively). In the subgroup of patients with tumor infiltration, we found that the papillary thyroid cancer histotype was the only potential predictor of fistula development. External beam radiation therapy (EBRT), the starting dose of lenvatinib, and the duration of treatment were not relevant for the development of fistula. <b><i>Conclusions:</i></b> In metastatic thyroid cancer patients treated with lenvatinib, the presence of tumor infiltration and histological type should be considered as potential risk factors for the development of fistula or organ perforation, although they do not represent an absolute contraindication. Although EBRT and the presence of diverticulosis were not significantly associated with the development of fistula and organ perforation, they should be regarded as potential additional reasons for the development of these complications. According to our findings, there is no reason to start lenvatinib at a lower daily dose when tumor infiltration is present.
DOI: 10.17632/tbns9wthxt.1
title: Data for: The Environmental Tolerances and Metabolic Physiology of Sablefish (Anoplopoma fimbria)

description: Enclosed are the raw data for the tables and figures, along with a statistical analysis summary, related to the manuscript "The Environmental Tolerances and Metabolic Physiology of Sablefish (Anoplopoma fimbria)".
DOI: 10.15468/txha93
title: A new species of the genus Daplasa Moore from China based on morphological and molecular evidence (Lepidoptera: Erebidae: Lymantriinae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article An, Xuan, Da, Wa, Wang, Min, Wang, Houshuai (2021): A new species of the genus Daplasa Moore from China based on morphological and molecular evidence (Lepidoptera: Erebidae: Lymantriinae). Zootaxa 4948 (3): 439-446, DOI: https://doi.org/10.11646/zootaxa.4948.3.8
DOI: 10.25403/upresearchdata.13302569
title: Using the multilevel perspective framework to understand the transition of South Africa’s mining sector to a circular economy

description: Datasets consists of audio recordings of the interviews and the reports from the qualitative analysis from Atlas Ti as well as audio files of interviews from mining sector.
DOI: 10.25403/upresearchdata.13302569.v1
title: Using the multilevel perspective framework to understand the transition of South Africa’s mining sector to a circular economy

description: Datasets consists of audio recordings of the interviews and the reports from the qualitative analysis from Atlas Ti as well as audio files of interviews from mining sector.
DOI: 10.5281/zenodo.4624234
title: Total Italian Population Monthly 0-43 year of age - ISTAT

description: Total Italian Population - ISTAT - monthly time series Agregation level: comuni
DOI: 10.5281/zenodo.4624233
title: Total Italian Population Monthly 0-43 year of age - ISTAT

description: Total Italian Population - ISTAT - monthly time series Agregation level: comuni
DOI: 10.5281/zenodo.2633013
title: A Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: proof of concept with PCB153 and two freshwater species.

description: R Codes and corresponding .csv data files for estimating toxicokinetic model parameters for both chironomids and gammarids exposed to PCB153.
DOI: 10.5281/zenodo.2633012
title: A Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: proof of concept with PCB153 and two freshwater species.

description: R Codes and corresponding .csv data files for estimating toxicokinetic model parameters for both chironomids and gammarids exposed to PCB153.
DOI: 10.5281/zenodo.4629216
title: Deglacial ice sheet instabilities induced by proglacial lakes

description: This archive provides the GRISLI ice sheet model outputs as part of the manuscript "Deglacial ice sheet instabilities induced by proglacial lakes". Contact: aurelien.quiquet@lsce.ipsl.fr
DOI: 10.5281/zenodo.4629215
title: Deglacial ice sheet instabilities induced by proglacial lakes

description: This archive provides the GRISLI ice sheet model outputs as part of the manuscript "Deglacial ice sheet instabilities induced by proglacial lakes". Contact: aurelien.quiquet@lsce.ipsl.fr
DOI: 10.5281/zenodo.4409538
title: Enantioselective Modification of Sulfonamides and SulfonamideContaining Drugs via Carbene Organic Catalysis

description: This folder /xyz_structures/ contains the geometries (in .xyz format together with the energy, E, in Hartree) accompanying the paper<br> "Carbene Catalyzed Enantioselective Synthesis of Phthalidyl Sulfonamides" Where conformers occur, they are always named from the lowest Gibbs energy to the highest in ascending order from c1 (sometimes omitted), c2, c3, ... This folder has the following structure and they correspond to the raw data in the SI: <br> /int_II_confs/ <br> --&gt; conformers from conformational sampling of acyl azolium intermediate II using SMD(DCM)-M06-2X/def2-TZVP//M06-2X/def2-SVP level of theory. /with_Li_ion/ <br> --&gt; structures for the reaction between acyl azolium intermediate II and lithium sulfonamide with explicit Li+ ion participation. /without_Li_ion/ <br> --&gt; structures for the reaction between acyl azolium intermediate II and deprotonated sulfonamide without explicit Li+ ion participation.
DOI: 10.5281/zenodo.4381663
title: Enantioselective Modification of Sulfonamides and SulfonamideContaining Drugs via Carbene Organic Catalysis

description: This folder /xyz_structures/ contains the geometries (in .xyz format together with the energy, E, in Hartree) accompanying the paper<br> "Carbene Catalyzed Enantioselective Synthesis of Phthalidyl Sulfonamides" Where conformers occur, they are always named from the lowest Gibbs energy to the highest in ascending order from c1 (sometimes omitted), c2, c3, ... This folder has the following structure and they correspond to the raw data in the SI: <br> /int_II_confs/ <br> --&gt; conformers from conformational sampling of acyl azolium intermediate II using SMD(DCM)-M06-2X/def2-TZVP//M06-2X/def2-SVP level of theory. /with_Li_ion/ <br> --&gt; structures for the reaction between acyl azolium intermediate II and lithium sulfonamide with explicit Li+ ion participation. /without_Li_ion/ <br> --&gt; structures for the reaction between acyl azolium intermediate II and deprotonated sulfonamide without explicit Li+ ion participation.
DOI: 10.5281/zenodo.3780090
title: Supplementary data: The added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates.

description: Supporting information for the article "<strong>The added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates.</strong>" This provides all the R script and .csv files for each dataset.
DOI: 10.5281/zenodo.3780089
title: Supplementary data: The added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates.

description: Supporting information for the article "<strong>The added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates.</strong>" This provides all the R script and .csv files for each dataset.
DOI: 10.5281/zenodo.4629233
title: Monthly Italian Number of Deaths period 2015-2020 - ISTAT

description: Monthly number of deaths in Italy broken down of NUT-1 Code, Municipality, gender, and specific range of age (65+)
DOI: 10.25403/upresearchdata.13311893
title: Role of tax incentives on investments in venture capital companies in South Africa - a VCC perspective

description: This is a qualitative study and obtained data from Executives or Senior Management at Venture Capital Companies through interviews. Data was obtained from transcripts and the voice recordings as well as approved consent forms from research participants.
DOI: 10.25403/upresearchdata.13311893.v1
title: Role of tax incentives on investments in venture capital companies in South Africa - a VCC perspective

description: This is a qualitative study and obtained data from Executives or Senior Management at Venture Capital Companies through interviews. Data was obtained from transcripts and the voice recordings as well as approved consent forms from research participants.
DOI: 10.5281/zenodo.4629232
title: Monthly Italian Number of Deaths period 2015-2020 - ISTAT

description: Monthly number of deaths in Italy broken down of NUT-1 Code, Municipality, gender, and specific range of age (65+)