cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23290675
title: Neck circumference and its association with anthropometric, clinical, and biochemical parameters in patients with chronic kidney disease on hemodialysis

description: ABSTRACT Objective: To investigate the association between neck circumference and anthropometric, clinical, and biochemical parameters in chronic kidney failure patients on hemodialysis. Methods: This is a cross-sectional study with patients with chronic kidney disease undergoing hemodialysis in Western Bahia. For the data collection, anthropometric measures were taken and clinical and biochemical data were gathered from the patient records and employing a structured questionnaire. A multiple linear regression was applied to evaluate the relationship between neck circumference and the anthropometric, clinical, and biochemical parameters. Results: A total of 119 patients were evaluated, of which 63.03% were men and 57.98% were aged between 35 and 59 years old. The mean neck circumference of the patients was 36.2±3.8 cm. A negative association was found between neck circumference and the female sex (p&lt;0.001), while waist circumference (p&lt;0.001), the body adiposity index (p=0.002), and pre-dialysis serum urea concentration (p=0.006) were positively associated with neck circumference. Conclusion: Neck circumference is inversely associated with the female sex and positively associated with a high waist circumference, body adiposity index, and serum urea concentration in patients with chronic kidney disease on hemodialysis.
DOI: 10.6084/m9.figshare.23290675.v1
title: Neck circumference and its association with anthropometric, clinical, and biochemical parameters in patients with chronic kidney disease on hemodialysis

description: ABSTRACT Objective: To investigate the association between neck circumference and anthropometric, clinical, and biochemical parameters in chronic kidney failure patients on hemodialysis. Methods: This is a cross-sectional study with patients with chronic kidney disease undergoing hemodialysis in Western Bahia. For the data collection, anthropometric measures were taken and clinical and biochemical data were gathered from the patient records and employing a structured questionnaire. A multiple linear regression was applied to evaluate the relationship between neck circumference and the anthropometric, clinical, and biochemical parameters. Results: A total of 119 patients were evaluated, of which 63.03% were men and 57.98% were aged between 35 and 59 years old. The mean neck circumference of the patients was 36.2±3.8 cm. A negative association was found between neck circumference and the female sex (p&lt;0.001), while waist circumference (p&lt;0.001), the body adiposity index (p=0.002), and pre-dialysis serum urea concentration (p=0.006) were positively associated with neck circumference. Conclusion: Neck circumference is inversely associated with the female sex and positively associated with a high waist circumference, body adiposity index, and serum urea concentration in patients with chronic kidney disease on hemodialysis.
DOI: 10.6084/m9.figshare.22633576.v1
title: Fast synthesis of large-area bilayer graphene film on Cu

description: The attached excel file include all the source data required, including Raman spectra and mapping, electrical, TEM measurement results, and the statistical results.
DOI: 10.6084/m9.figshare.22633576
title: Fast synthesis of large-area bilayer graphene film on Cu

description: The attached excel file include all the source data required, including Raman spectra and mapping, electrical, TEM measurement results, and the statistical results.
DOI: 10.6084/m9.figshare.22658980.v1
title: NOTCH4ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1

description: Resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) remains one of the major challenges in lung adenocarcinoma (LUAD) therapy. Here, we found an increased frequency of the L12_16 amino acid deletion mutation in the signal peptide region of NOTCH4 (NOTCH4ΔL12_16) in EGFR-TKI-sensitive patients. Functionally, exogenous induction of NOTCH4ΔL12_16 in EGFR-TKI -resistant LUAD cells sensitized them to EGFR-TKIs. This process was mainly mediated by the reduction of the intracellular domain of NOTCH4 (NICD4) caused by the NOTCH4ΔL12_16 mutation, which resulted in a lower localization of NOTCH4 in the plasma membrane. Mechanistically, NICD4 could transcriptionally upregulate the expression of HES1 by competitively binding to the gene promoter relative to p-STAT3. Because p-STAT3 can downregulate the expression of HES1 in EGFR-TKI-resistant LUAD cells, the reduction of NICD4 induced by NOTCH4ΔL12_16 mutation, leads to a decrease in HES1. Moreover, inhibition of the NOTCH4-HES1 pathway using inhibitors and siRNAs abolished the resistance of EGFR-TKI. Overall, we report that the NOTCH4ΔL12_16 mutation sensitizes LUAD patients to EGFR-TKIs through transcriptional down-regulation of HES1 and that targeted blockade of this signaling cohort could reverse EGFR-TKI -resistance in LUAD, providing a potential approach to overcome resistance to EGFR-TKI -therapy.
DOI: 10.6084/m9.figshare.22658980
title: NOTCH4ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1

description: Resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) remains one of the major challenges in lung adenocarcinoma (LUAD) therapy. Here, we found an increased frequency of the L12_16 amino acid deletion mutation in the signal peptide region of NOTCH4 (NOTCH4ΔL12_16) in EGFR-TKI-sensitive patients. Functionally, exogenous induction of NOTCH4ΔL12_16 in EGFR-TKI -resistant LUAD cells sensitized them to EGFR-TKIs. This process was mainly mediated by the reduction of the intracellular domain of NOTCH4 (NICD4) caused by the NOTCH4ΔL12_16 mutation, which resulted in a lower localization of NOTCH4 in the plasma membrane. Mechanistically, NICD4 could transcriptionally upregulate the expression of HES1 by competitively binding to the gene promoter relative to p-STAT3. Because p-STAT3 can downregulate the expression of HES1 in EGFR-TKI-resistant LUAD cells, the reduction of NICD4 induced by NOTCH4ΔL12_16 mutation, leads to a decrease in HES1. Moreover, inhibition of the NOTCH4-HES1 pathway using inhibitors and siRNAs abolished the resistance of EGFR-TKI. Overall, we report that the NOTCH4ΔL12_16 mutation sensitizes LUAD patients to EGFR-TKIs through transcriptional down-regulation of HES1 and that targeted blockade of this signaling cohort could reverse EGFR-TKI -resistance in LUAD, providing a potential approach to overcome resistance to EGFR-TKI -therapy.
DOI: 10.6084/m9.figshare.22698778.v1
title: Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults

description: Source data are provided with the paper, where the relevant data from each figure or table is represented by a single sheet within the source data file. Each sheet is named after the corresponding figure/ table.
DOI: 10.6084/m9.figshare.22699366.v1
title: Critical roles of metal-ligand complexes in the controlled synthesis of various metal nanoclusters

description: Experimental data are provided in the figures and Supplementary Information. Additional data are available from the corresponding authors upon request.
DOI: 10.6084/m9.figshare.22698778
title: Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults

description: Source data are provided with the paper, where the relevant data from each figure or table is represented by a single sheet within the source data file. Each sheet is named after the corresponding figure/ table.
DOI: 10.6084/m9.figshare.22699366
title: Critical roles of metal-ligand complexes in the controlled synthesis of various metal nanoclusters

description: Experimental data are provided in the figures and Supplementary Information. Additional data are available from the corresponding authors upon request.
DOI: 10.6084/m9.figshare.22806845.v1
title: Two RhoGEF isoforms with distinct localisation control furrow position during asymmetric cell division

description: Source data file as excel spreadsheet containing all data generated and published in this manuscript.
DOI: 10.6084/m9.figshare.22806845
title: Two RhoGEF isoforms with distinct localisation control furrow position during asymmetric cell division

description: Source data file as excel spreadsheet containing all data generated and published in this manuscript.
DOI: 10.6084/m9.figshare.23290678
title: Alternatives to stabilization: gradualismo, dollarization, and populism

description: ABSTRACT The paper discusses the issues involved in three different varieties of stabilization plans: gradualism, dollarization, and social pacts. It is argued that the efficiency of each alternative depends upon special conditions pertaining, by and large to the dynamics of price fixing in the Brazilian economy. Shock alternatives in particular, namely, price freezes or pre-fixing schemes, are said to have their usefulness attached to “backwards looking” price fixing behavior. Gradual strategies, on the other hand, especially when unambiguously orthodox, are said to be more efficient when “forward looking” behavior is adopted by price setters. The paper also discusses the conditions for the application of an Argentinean type dollarization in Brazil and also institutional peculiarities affecting the feasibility of “social pacts” in Brazil.
DOI: 10.6084/m9.figshare.23290678.v1
title: Alternatives to stabilization: gradualismo, dollarization, and populism

description: ABSTRACT The paper discusses the issues involved in three different varieties of stabilization plans: gradualism, dollarization, and social pacts. It is argued that the efficiency of each alternative depends upon special conditions pertaining, by and large to the dynamics of price fixing in the Brazilian economy. Shock alternatives in particular, namely, price freezes or pre-fixing schemes, are said to have their usefulness attached to “backwards looking” price fixing behavior. Gradual strategies, on the other hand, especially when unambiguously orthodox, are said to be more efficient when “forward looking” behavior is adopted by price setters. The paper also discusses the conditions for the application of an Argentinean type dollarization in Brazil and also institutional peculiarities affecting the feasibility of “social pacts” in Brazil.
DOI: 10.6084/m9.figshare.23290685
title: A master of the Brazilian economy: Ignácio Rangel

description: ABSTRACT Ignácio Rangel may be the more original analyst of the Brazilian economic development. His contribution was made particularly in the 1950s and 1960s. Influenced by Keynes and Marx, he adopts a historical and dialectical method. He was the first Brazilian economist to introduce the Kondratieff’ long cycles in the analysis of the Brazilian economy. ln his analysis of Brazil, he always stressed its dual and dynamic character, where the long cycles and changing process of leading social classes presides the process of accumulation in new sectors of the economy, transferring resources from the sector with idle capacity. His major contribution, however, was in inflation theory. He criticized the monetarist and the structuralist views of inflation and showed the endogenous character of the money supply in a pioneering way. As early as 1978 he realized the financial crisis of the state and, in spite of his left leaning position, proposed the privatization of public utilities.
DOI: 10.6084/m9.figshare.23290684
title: Compounds identified in plant extracts applied to agriculture and seed treatment

description: ABSTRACT: Plant extracts effects have been regarded and proven in researches under different applications in agriculture, including seed treatment. The plant extracts effectiveness is attributed to the presence of certain classes of compounds; therefore, studies that aim to identify and quantify these composites, which are present in plant extracts used in agriculture, are important, as well as the seed treatment. This research aimed to understand and describe through a systematic review, what were the main carried approaches, classes and identified compounds in studies with plant extracts to different applications in agriculture and the seed treatment. The period 2015 to 2020 was the one that exposed the higher research publication indexes, considering the theme under analysis, plant extracts in agriculture, seeking to identify or quantify the presence of metabolic composites, indicating a growing interest in this theme. Such studies pursued identifying and/or quantifying the compounds that are present in the plant extracts. The phenolic compounds constitute the priority class of metabolites to different functions, effects and applications in agriculture, mainly in seed treatment. The terpenes present a substantial potential as bioinsecticides to agriculture. Plant species that are rich in phenolic and terpenes compounds are a significant source of alternative control in the protection of the productive system.
DOI: 10.6084/m9.figshare.23290684.v1
title: Compounds identified in plant extracts applied to agriculture and seed treatment

description: ABSTRACT: Plant extracts effects have been regarded and proven in researches under different applications in agriculture, including seed treatment. The plant extracts effectiveness is attributed to the presence of certain classes of compounds; therefore, studies that aim to identify and quantify these composites, which are present in plant extracts used in agriculture, are important, as well as the seed treatment. This research aimed to understand and describe through a systematic review, what were the main carried approaches, classes and identified compounds in studies with plant extracts to different applications in agriculture and the seed treatment. The period 2015 to 2020 was the one that exposed the higher research publication indexes, considering the theme under analysis, plant extracts in agriculture, seeking to identify or quantify the presence of metabolic composites, indicating a growing interest in this theme. Such studies pursued identifying and/or quantifying the compounds that are present in the plant extracts. The phenolic compounds constitute the priority class of metabolites to different functions, effects and applications in agriculture, mainly in seed treatment. The terpenes present a substantial potential as bioinsecticides to agriculture. Plant species that are rich in phenolic and terpenes compounds are a significant source of alternative control in the protection of the productive system.
DOI: 10.6084/m9.figshare.23290685.v1
title: A master of the Brazilian economy: Ignácio Rangel

description: ABSTRACT Ignácio Rangel may be the more original analyst of the Brazilian economic development. His contribution was made particularly in the 1950s and 1960s. Influenced by Keynes and Marx, he adopts a historical and dialectical method. He was the first Brazilian economist to introduce the Kondratieff’ long cycles in the analysis of the Brazilian economy. ln his analysis of Brazil, he always stressed its dual and dynamic character, where the long cycles and changing process of leading social classes presides the process of accumulation in new sectors of the economy, transferring resources from the sector with idle capacity. His major contribution, however, was in inflation theory. He criticized the monetarist and the structuralist views of inflation and showed the endogenous character of the money supply in a pioneering way. As early as 1978 he realized the financial crisis of the state and, in spite of his left leaning position, proposed the privatization of public utilities.
DOI: 10.6084/m9.figshare.23290690.v1
title: Glyceryl guaiacol ether for sedation of horses undergoing orchiectomy when standing

description: ABSTRACT A study was designed to compare two sedation protocols to be used in horses undergoing orchiectomy when standing. In both protocols, the induction to the sedative state was performed with bolus detomidine at a dose of 10 µg/kg, intravenously (IV). In the first protocol (eight horses), the sedative state was maintained with 1% glyceryl guaiacol ether (GGE) in continuous infusion, at a dose of 1ml/kg/hour IV. In the second protocol (eight horses) this sedative effect was maintained with detomidine in continuous infusion at the same dose and induction route. Orchiectomy was performed on all animals. The two protocols allowed the surgeries to be performed when standing. However, horses kept under sedation by the GGE showed greater relaxation and a more intense degree of sedation. It should be noted that the use of GGE to maintain the sedative state in horses is unprecedented in the literature. The drug is used in anesthetic protocols in the species, but only in pre-anesthetic medication in general anesthesia. It was concluded that the two sedation protocols allowed the performance of orchiectomy with the horses when standing. However, the protocol in which 1% GGE was used showed more profound sedation, without adverse effects.
DOI: 10.6084/m9.figshare.23290690
title: Glyceryl guaiacol ether for sedation of horses undergoing orchiectomy when standing

description: ABSTRACT A study was designed to compare two sedation protocols to be used in horses undergoing orchiectomy when standing. In both protocols, the induction to the sedative state was performed with bolus detomidine at a dose of 10 µg/kg, intravenously (IV). In the first protocol (eight horses), the sedative state was maintained with 1% glyceryl guaiacol ether (GGE) in continuous infusion, at a dose of 1ml/kg/hour IV. In the second protocol (eight horses) this sedative effect was maintained with detomidine in continuous infusion at the same dose and induction route. Orchiectomy was performed on all animals. The two protocols allowed the surgeries to be performed when standing. However, horses kept under sedation by the GGE showed greater relaxation and a more intense degree of sedation. It should be noted that the use of GGE to maintain the sedative state in horses is unprecedented in the literature. The drug is used in anesthetic protocols in the species, but only in pre-anesthetic medication in general anesthesia. It was concluded that the two sedation protocols allowed the performance of orchiectomy with the horses when standing. However, the protocol in which 1% GGE was used showed more profound sedation, without adverse effects.
DOI: 10.6084/m9.figshare.23290693
title: Tin cartel: the two faces of the process

description: ABSTRACT The first part deals with the concentration and integration processes that took place in the tin mining industry during the 1920’s. It is argued that the articulation of the extractive and metallurgical sectors, although allowing for a better grip of world tin supply, turned the industry as a whole less capable of adjusting itself to market conditions. The second part shows the adverse effects of the policies implemented by the International Tin Committee. Finally, the path that led to the nationalization of the industry in the producing countries and the ways through which the reins of the market passed to the consumption side are also considered.
DOI: 10.6084/m9.figshare.23290693.v1
title: Tin cartel: the two faces of the process

description: ABSTRACT The first part deals with the concentration and integration processes that took place in the tin mining industry during the 1920’s. It is argued that the articulation of the extractive and metallurgical sectors, although allowing for a better grip of world tin supply, turned the industry as a whole less capable of adjusting itself to market conditions. The second part shows the adverse effects of the policies implemented by the International Tin Committee. Finally, the path that led to the nationalization of the industry in the producing countries and the ways through which the reins of the market passed to the consumption side are also considered.
DOI: 10.6084/m9.figshare.23290697
title: Boron sources and rates on soybean seed physiological quality and root system volume

description: Abstract: Soybean has shown increasing performance in terms of yield in recent years. However, despite this growth, the lack of quality control and knowledge about the effects of the nutritional status of plants has compromised the germination and vigor of a significant proportion of seeds. The aim of this study was to evaluate the physiological performance of seeds and root growth of soybean cultivated with boron (B) sources with different solubilities incorporated into the soil. The experimental design was completely randomized in a 2×5 factorial arrangement, with two B sources (boric acid and ulexite) and five B rates (0, 2, 4, 8, and 16 mg.kg-1). 100-seed weight (100SW), germination, seedling shoot length (SSL), seedling root length (SRL), accelerated aging (AA), root protrusion (RP), lignin content in the seed coat (LCSC), and root volume (RV) were evaluated. The B sources and rates showed a significant interaction with increases in RV, RP, SSL, SRL, and 100SW, while the LCSC decreased with increasing rates with no interaction effect, indicating a reduction of seed quality with rates up to 8.0 mg.kg-1, regardless of the B source used.
DOI: 10.6084/m9.figshare.23290697.v1
title: Boron sources and rates on soybean seed physiological quality and root system volume

description: Abstract: Soybean has shown increasing performance in terms of yield in recent years. However, despite this growth, the lack of quality control and knowledge about the effects of the nutritional status of plants has compromised the germination and vigor of a significant proportion of seeds. The aim of this study was to evaluate the physiological performance of seeds and root growth of soybean cultivated with boron (B) sources with different solubilities incorporated into the soil. The experimental design was completely randomized in a 2×5 factorial arrangement, with two B sources (boric acid and ulexite) and five B rates (0, 2, 4, 8, and 16 mg.kg-1). 100-seed weight (100SW), germination, seedling shoot length (SSL), seedling root length (SRL), accelerated aging (AA), root protrusion (RP), lignin content in the seed coat (LCSC), and root volume (RV) were evaluated. The B sources and rates showed a significant interaction with increases in RV, RP, SSL, SRL, and 100SW, while the LCSC decreased with increasing rates with no interaction effect, indicating a reduction of seed quality with rates up to 8.0 mg.kg-1, regardless of the B source used.