cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5630314.v1
title: Valence-space associations in touchscreen interactions

description: Dataset, database and code concerning the manuscript: "Valence-space associations in touchscreen interactions: Valence match between emotional pictures and touch location leads to pictures' positive evaluation" (submitted manuscript )
DOI: 10.6084/m9.figshare.5630254
title: FE Models of Fetal Kick Reaction Force

description: Models for predicting fetal kick reaction force.
DOI: 10.6084/m9.figshare.5630263.v2
title: FE Models of Fetal Stress & Strain

description: Models for predicting stress and strain in the fetal skeleton.
DOI: 10.6084/m9.figshare.5630314.v2
title: Valence-space associations in touchscreen interactions

description: Dataset, database and code concerning the manuscript: "Valence-space associations in touchscreen interactions: Valence match between emotional pictures and touch location leads to pictures' positive evaluation"
DOI: 10.6084/m9.figshare.5630242
title: Thai SNOT-22

description: This is the data used in validity and reliability study of Thai SNOT-22 questionnaire
DOI: 10.6084/m9.figshare.5630245
title: MATLAB Code for Fetal Movement Tracking

description: Code for tracking fetal movements.
DOI: 10.6084/m9.figshare.5630263.v1
title: FE Models of Fetal Stress & Strain

description: Models for predicting stress and strain in the fetal skeleton.
DOI: 10.6084/m9.figshare.5630314.v4
title: Valence

description: Metadata
DOI: 10.6084/m9.figshare.5630242.v1
title: Thai SNOT-22

description: This is the data used in validity and reliability study of Thai SNOT-22 questionnaire
DOI: 10.6084/m9.figshare.5630233
title: Supplementary Material for: A Native Haitian Woman with Unverricht-Lundborg Disease

description: Unverricht-Lundborg disease (ULD) is an autosomal recessive progressive myoclonic epilepsy. The prevalence is highest in specific European countries and North Africa. Affected individuals have myoclonic and tonic-clonic seizures and a variable degree of ataxia and cognitive impairment. We report a native Haitian woman with ULD who was wheelchair bound due to nearly continuous myoclonic seizures exacerbated by activity and emotional distress. The seizures and their dramatic increase with volitional activity were recorded during video electroencephalography monitoring. Rational antiepileptic drug therapy controlled the seizures well enough for the patient to achieve a level of independence she had not experienced in over 25 years.
DOI: 10.6084/m9.figshare.5630314.v3
title: Valence-space associations in touchscreen interactions

description: Dataset, database and code concerning the manuscript: "Valence-space associations in touchscreen interactions: Valence match between emotional pictures and touch location leads to pictures' positive evaluation"
DOI: 10.6084/m9.figshare.5630182
title: Differential gene expression in heterophils isolated from commercial hybrid and Thai indigenous broiler chickens under quercetin supplementation

description: Chicken heterophils serve as the first-line defence in chicken innate immunity. The present study aimed to explore the effects of quercetin, a herbal phenolic substance known for its inflammatory modulation, on mRNA expression patterns in chicken heterophils. Isolated heterophils from two genetically distinct chicken lines, hybrid commercial and Thai indigenous chickens, Pradu Hang Dam, were <i>in vitro</i> co-cultured with live intestinal pathogenic <i>Salmonella enteritidis</i> under Phosphate-buffered saline (PBS) or quercetin supplementation. Quantitative real-time RT-PCR was performed to investigate the effects of quercetin on mRNA transcripts of 12 genes. The results showed that heterophils from hybrid chickens treated with quercetin had higher relative expression levels of <i>IL6</i>, <i>IL8L1</i>, <i>IL8L2</i>, <i>IL18</i>, <i>CCL4</i>, <i>LITAF</i>, and <i>MIF</i>. Unlike hybrid chickens, Pradu Hang Dam chickens had down-regulation of cytokine genes, <i>IL1B</i>, <i>IL6</i>, <i>IL8L1</i>, <i>IL8L2</i>, <i>IL12B</i>, and <i>IL18</i>, and chemokines, <i>CCL4</i> and <i>MIF</i>. In addition, <i>NOS2, IL17A</i>, and <i>TGFB1</i> were up-regulated in this lineage. In conclusion, our findings emphasize the modulatory effects of quercetin to down-regulate most pro-inflammatory genes, whereas it up-regulates anti-inflammatory gene (<i>TGFB1</i>) in Pradu Hang Dam chickens.
DOI: 10.6084/m9.figshare.5630188
title: Timing the tectonic mingling of ultramafic rocks and metasediments in the southern section of the coastal accretionary complex of central Chile

description: Uranium-lead ages are reported for zircons from ultramafic bodies and metamorphic host rocks of the Western Series that outcrop at La Cabaña, in the southern section of the coastal accretionary complex of central Chile. Metasedimentary mica schists hosting the ultramafic bodies contain a main detrital zircon population of Devonian age (365–380 Ma) clustering around ~368 Ma, differing significantly from neighbouring areas where Devonian zircons are scarce. Zircons from the metasomatic reaction zones (albitites and chloritites), formed during the emplacement and alteration of the ultramafic bodies, are mainly Ordovician (~478 Ma) and lack Devonian zircons, resembling a typical detrital zircon pattern from other locations in the Western Series. Zircons from the chloritite reaction zone of the Lavanderos serpentinite, the easternmost ultramafic body in La Cabaña, are in textural equilibrium with metamorphic ilmenite. Some of these zircons yield an average age of 283.4 ± 7 Ma (<i>n</i> = 6) which is identical, within error, to a previously reported K-Ar fuchsite cooling age of 282 ± 6 Ma from the reaction zone. Most zircons extracted from chromitite boulders have euhedral oscillatory-zoned growth patterns with a similar range of ages than those reported for the Western Series (324–1090 Ma; <i>n</i> = 12), except for two zircons with cloudy appearance and high U/Th ratios which yielded an average age of 285.5 ± 7 Ma. The presence of Early Permian zircons (~280–290 Ma) in all studied rocks suggests remobilization of Zr, possibly triggered by metasomatic fluids released during the disequilibrium reaction associated with the tectonic emplacement of the ultramafic rocks into the metasedimentary rock. Simultaneously with the formation of metasomatic zircons, Palaeozoic and Mesoproterozoic zircons from the metasedimentary rocks were mechanically incorporated into the ultramafic rocks, thus providing a record of the timing of crustal emplacement of the ultramafic rocks into the accretionary complex.
DOI: 10.6084/m9.figshare.5630188.v1
title: Timing the tectonic mingling of ultramafic rocks and metasediments in the southern section of the coastal accretionary complex of central Chile

description: Uranium-lead ages are reported for zircons from ultramafic bodies and metamorphic host rocks of the Western Series that outcrop at La Cabaña, in the southern section of the coastal accretionary complex of central Chile. Metasedimentary mica schists hosting the ultramafic bodies contain a main detrital zircon population of Devonian age (365–380 Ma) clustering around ~368 Ma, differing significantly from neighbouring areas where Devonian zircons are scarce. Zircons from the metasomatic reaction zones (albitites and chloritites), formed during the emplacement and alteration of the ultramafic bodies, are mainly Ordovician (~478 Ma) and lack Devonian zircons, resembling a typical detrital zircon pattern from other locations in the Western Series. Zircons from the chloritite reaction zone of the Lavanderos serpentinite, the easternmost ultramafic body in La Cabaña, are in textural equilibrium with metamorphic ilmenite. Some of these zircons yield an average age of 283.4 ± 7 Ma (<i>n</i> = 6) which is identical, within error, to a previously reported K-Ar fuchsite cooling age of 282 ± 6 Ma from the reaction zone. Most zircons extracted from chromitite boulders have euhedral oscillatory-zoned growth patterns with a similar range of ages than those reported for the Western Series (324–1090 Ma; <i>n</i> = 12), except for two zircons with cloudy appearance and high U/Th ratios which yielded an average age of 285.5 ± 7 Ma. The presence of Early Permian zircons (~280–290 Ma) in all studied rocks suggests remobilization of Zr, possibly triggered by metasomatic fluids released during the disequilibrium reaction associated with the tectonic emplacement of the ultramafic rocks into the metasedimentary rock. Simultaneously with the formation of metasomatic zircons, Palaeozoic and Mesoproterozoic zircons from the metasedimentary rocks were mechanically incorporated into the ultramafic rocks, thus providing a record of the timing of crustal emplacement of the ultramafic rocks into the accretionary complex.
DOI: 10.6084/m9.figshare.5630182.v1
title: Differential gene expression in heterophils isolated from commercial hybrid and Thai indigenous broiler chickens under quercetin supplementation

description: Chicken heterophils serve as the first-line defence in chicken innate immunity. The present study aimed to explore the effects of quercetin, a herbal phenolic substance known for its inflammatory modulation, on mRNA expression patterns in chicken heterophils. Isolated heterophils from two genetically distinct chicken lines, hybrid commercial and Thai indigenous chickens, Pradu Hang Dam, were <i>in vitro</i> co-cultured with live intestinal pathogenic <i>Salmonella enteritidis</i> under Phosphate-buffered saline (PBS) or quercetin supplementation. Quantitative real-time RT-PCR was performed to investigate the effects of quercetin on mRNA transcripts of 12 genes. The results showed that heterophils from hybrid chickens treated with quercetin had higher relative expression levels of <i>IL6</i>, <i>IL8L1</i>, <i>IL8L2</i>, <i>IL18</i>, <i>CCL4</i>, <i>LITAF</i>, and <i>MIF</i>. Unlike hybrid chickens, Pradu Hang Dam chickens had down-regulation of cytokine genes, <i>IL1B</i>, <i>IL6</i>, <i>IL8L1</i>, <i>IL8L2</i>, <i>IL12B</i>, and <i>IL18</i>, and chemokines, <i>CCL4</i> and <i>MIF</i>. In addition, <i>NOS2, IL17A</i>, and <i>TGFB1</i> were up-regulated in this lineage. In conclusion, our findings emphasize the modulatory effects of quercetin to down-regulate most pro-inflammatory genes, whereas it up-regulates anti-inflammatory gene (<i>TGFB1</i>) in Pradu Hang Dam chickens.
DOI: 10.6084/m9.figshare.5630149
title: Standardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists

description: <b>Introduction:</b> In breast cancer, there is a growing body of evidence that tumor-infiltrating lymphocytes (TILs) may have clinical utility and may be able to direct clinical decisions for subgroups of patients. Clinical utility is, however, not sufficient for warranting the implementation of a new biomarker in the routine practice, and evaluation of the analytical validity is needed, including testing the reproducibility of decentralized assessment of TILs. The aim of this study was to evaluate the inter-observer agreement of TILs assessment using a standardized method, as proposed by the International TILs Working Group 2014, applied to a cohort of breast cancers reflecting an average breast cancer population. <b>Material and methods:</b> Stromal TILs were assessed using full slide sections from 124 breast cancers with varying histology, malignancy grade and ER- and HER2 status. TILs were estimated by nine dedicated breast pathologists using scanned hematoxylin–eosin stainings. TILs results were categorized using various cutoffs, and the inter-observer agreement was evaluated using the intraclass coefficient (ICC), Kappa statistics as well as individual overall agreements with the median value of TILs. <b>Results:</b> Evaluation of TILs led to an ICC of 0.71 (95% CI: 0.65–0.77) corresponding to an acceptable agreement. Kappa values were in the range of 0.38–0.46 corresponding to a fair to moderate agreement. The individual agreements increased, when using only two categories (‘high’ vs. ‘low’ TILs) and a cutoff of 50–60%. <b>Discussion:</b> The results of the present study are in accordance with previous studies, and shows that the proposed methodology for standardized evaluation of TILs renders an acceptable inter-observer agreement. The findings, however, indicate that assessment of TILs needs further refinement, and is in support of the latest St. Gallen Consensus, that routine reporting of TILs for early breast cancer is not ready for implementation in a clinical setting.
DOI: 10.6084/m9.figshare.5630149.v1
title: Standardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists

description: <b>Introduction:</b> In breast cancer, there is a growing body of evidence that tumor-infiltrating lymphocytes (TILs) may have clinical utility and may be able to direct clinical decisions for subgroups of patients. Clinical utility is, however, not sufficient for warranting the implementation of a new biomarker in the routine practice, and evaluation of the analytical validity is needed, including testing the reproducibility of decentralized assessment of TILs. The aim of this study was to evaluate the inter-observer agreement of TILs assessment using a standardized method, as proposed by the International TILs Working Group 2014, applied to a cohort of breast cancers reflecting an average breast cancer population. <b>Material and methods:</b> Stromal TILs were assessed using full slide sections from 124 breast cancers with varying histology, malignancy grade and ER- and HER2 status. TILs were estimated by nine dedicated breast pathologists using scanned hematoxylin–eosin stainings. TILs results were categorized using various cutoffs, and the inter-observer agreement was evaluated using the intraclass coefficient (ICC), Kappa statistics as well as individual overall agreements with the median value of TILs. <b>Results:</b> Evaluation of TILs led to an ICC of 0.71 (95% CI: 0.65–0.77) corresponding to an acceptable agreement. Kappa values were in the range of 0.38–0.46 corresponding to a fair to moderate agreement. The individual agreements increased, when using only two categories (‘high’ vs. ‘low’ TILs) and a cutoff of 50–60%. <b>Discussion:</b> The results of the present study are in accordance with previous studies, and shows that the proposed methodology for standardized evaluation of TILs renders an acceptable inter-observer agreement. The findings, however, indicate that assessment of TILs needs further refinement, and is in support of the latest St. Gallen Consensus, that routine reporting of TILs for early breast cancer is not ready for implementation in a clinical setting.
DOI: 10.6084/m9.figshare.5630116
title: Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG)

description: <b>Introduction:</b> Neoadjuvant endocrine treatment (NET) is a low-toxicity approach to achieve operability in locally advanced breast cancer, and to facilitate breast conservation in early breast cancer, particular in patients with highly estrogen receptor (ER) positive and HER2-negative disease. Here, we report the results obtained by neoadjuvant letrozole in patients with early breast cancer in a phase-II design. <b>Material and methods:</b> A total of 119 postmenopausal women with ER-positive, HER2-negative operable breast cancer were assigned to four months of neoadjuvant letrozole before definitive surgery. Sentinel node or diagnostic fine needle aspiration cytology procedure was performed prior to treatment and the women were assessed prior, at two months, and before surgery with clinical examination, mammography and ultrasonography. Surgical specimens were examined for pathological response. Primary outcome was pathological and clinical response. <b>Results:</b> The per protocol population consisted of 112 patients. Clinical response was evaluated in 109 patients and pathological response in 108. Overall a mean decrease in tumor size was 15% (<i>p</i> ≤ .0001). One patient had complete pathological response and 55% of patients had partial pathological response. ER at 100%, ductal subtype, tumor size below 2 cm and lymph node–negative status was significantly associated with a better response to NET and malignancy grade 3 with a poorer response to NET. One patient progressed during treatment and received neoadjuvant chemotherapy. Eight patients received adjuvant chemotherapy due to lack of response. <b>Conclusion:</b> Neoadjuvant aromatase inhibitor therapy is an acceptable strategy in selected postmenopausal patients with ER-rich and HER2-negative early breast cancer with ductal histology and should be considered when chemotherapy either isn’t indicated or feasible.
DOI: 10.6084/m9.figshare.5630116.v1
title: Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG)

description: <b>Introduction:</b> Neoadjuvant endocrine treatment (NET) is a low-toxicity approach to achieve operability in locally advanced breast cancer, and to facilitate breast conservation in early breast cancer, particular in patients with highly estrogen receptor (ER) positive and HER2-negative disease. Here, we report the results obtained by neoadjuvant letrozole in patients with early breast cancer in a phase-II design. <b>Material and methods:</b> A total of 119 postmenopausal women with ER-positive, HER2-negative operable breast cancer were assigned to four months of neoadjuvant letrozole before definitive surgery. Sentinel node or diagnostic fine needle aspiration cytology procedure was performed prior to treatment and the women were assessed prior, at two months, and before surgery with clinical examination, mammography and ultrasonography. Surgical specimens were examined for pathological response. Primary outcome was pathological and clinical response. <b>Results:</b> The per protocol population consisted of 112 patients. Clinical response was evaluated in 109 patients and pathological response in 108. Overall a mean decrease in tumor size was 15% (<i>p</i> ≤ .0001). One patient had complete pathological response and 55% of patients had partial pathological response. ER at 100%, ductal subtype, tumor size below 2 cm and lymph node–negative status was significantly associated with a better response to NET and malignancy grade 3 with a poorer response to NET. One patient progressed during treatment and received neoadjuvant chemotherapy. Eight patients received adjuvant chemotherapy due to lack of response. <b>Conclusion:</b> Neoadjuvant aromatase inhibitor therapy is an acceptable strategy in selected postmenopausal patients with ER-rich and HER2-negative early breast cancer with ductal histology and should be considered when chemotherapy either isn’t indicated or feasible.
DOI: 10.6084/m9.figshare.5630092
title: Data used in analyses from Heterothermy is associated with reduced fitness in wild rabbits

description: Data used in analyses in the manuscript.
DOI: 10.6084/m9.figshare.5630086
title: Dataset ESM coal tit from Does oxidative stress shorten telomeres <i>in vivo</i>? A review

description: Excel file containing the coal tit data used as an example in ESM
DOI: 10.6084/m9.figshare.5630092.v1
title: Data used in analyses from Heterothermy is associated with reduced fitness in wild rabbits

description: Data used in analyses in the manuscript.
DOI: 10.6084/m9.figshare.5630086.v1
title: Dataset ESM coal tit from Does oxidative stress shorten telomeres <i>in vivo</i>? A review

description: Excel file containing the coal tit data used as an example in ESM
DOI: 10.6084/m9.figshare.5630071
title: Vascular and tissue changes of magnetic susceptibility in the mouse brain after transient cerebral ischemia

description: This is reconstructed magnitude, phase images and quantitative susceptibility maps of mice brains from gradient recalled echo data collected at different time points after middle cerebral artery occlusion and reperfusion. The methods and results are described in our publication in Translational Stroke Research 2017. Data are in NIfTI format.
DOI: 10.6084/m9.figshare.5630005
title: Vascular and tissue changes of magnetic susceptibility in the mouse brain after transient cerebral ischemia

description: This is reconstructed magnitude, phase images and quantitative susceptibility maps of mice brains from gradient recalled echo data collected at different time points after middle cerebral artery occlusion and reperfusion. The methods and results are described in our publication in Translational Stroke Research 2017. Data are in NIfTI format.
DOI: 10.6084/m9.figshare.5630014
title: Blastocyst images

description: Bos indicus blastocyst images
DOI: 10.6084/m9.figshare.5630005.v1
title: Vascular and tissue changes of magnetic susceptibility in the mouse brain after transient cerebral ischemia

description: This is reconstructed magnitude, phase images and quantitative susceptibility maps of mice brains from gradient recalled echo data collected at different time points after middle cerebral artery occlusion and reperfusion. The methods and results are described in our publication in Translational Stroke Research 2017. Data are in NIfTI format.
DOI: 10.6084/m9.figshare.5629996
title: How politics matters for EU funds’ absorption problems – a fuzzy-set analysis

description: This article explores the role of politics for member states’ absorption problems of European Union (EU) funds. Existing research relies solely on the influence of administrative capacities, but more recent evidence points at the additional relevance of politics as the party politicization of the implementation process. Drawing on this evidence, I argue that parties alternating in control of EU funds change implementation priorities and even management staff according to their preferences. These changes interrupt implementation, weaken capacities, and thereby also contribute to absorption problems. The argument is tested in a fuzzy-set qualitative comparative analysis of 17 operational programmes building large infrastructure in the new member states of the EU. The results strongly support a role of frequent party alternation and low capacities leading in conjunction to absorption problems. Low capacities are found to be an important, but crucially not a sufficient condition for absorption problems.
DOI: 10.6084/m9.figshare.5629996.v1
title: How politics matters for EU funds’ absorption problems – a fuzzy-set analysis

description: This article explores the role of politics for member states’ absorption problems of European Union (EU) funds. Existing research relies solely on the influence of administrative capacities, but more recent evidence points at the additional relevance of politics as the party politicization of the implementation process. Drawing on this evidence, I argue that parties alternating in control of EU funds change implementation priorities and even management staff according to their preferences. These changes interrupt implementation, weaken capacities, and thereby also contribute to absorption problems. The argument is tested in a fuzzy-set qualitative comparative analysis of 17 operational programmes building large infrastructure in the new member states of the EU. The results strongly support a role of frequent party alternation and low capacities leading in conjunction to absorption problems. Low capacities are found to be an important, but crucially not a sufficient condition for absorption problems.