cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25934/pr00010158
title: Biomarker-based strategies to enhance efficacy and reduce toxicity in lung cancer immunotherapy

description: Lung cancer is the 2nd most common cancer worldwide. It is the most common cancer in men and the 2nd most common cancer in women. There were more than 2.2 million new cases of lung cancer in 2020. Among them, immune checkpoint blockaded (ICB) immunotherapy is the mainstay treatment of patients. Immune checkpoint blockaded (ICB) therapy works by blocking proteins that stop the immune system from attacking the cancer cells. They allow the immune system to recognize and kill the cancer cells.

Types of ICB include anti-programmed cell death protein 1 (PD-1) and anti-programmed-death-ligand 1 (PD-L1), which are the recommended first treatment of non-small cell lung cancer. However, ICB is only effective for about 30-40% of patients (they are ICB-sensitive). Additionally, patients for whom ICB works often experience undesired side effects, know as immune-related adverse events (irAEs). Previous studies have witnessed that patients with irAEs during ICB therapy are prone to have a better overall survival and response to ICB therapy. However, severe irAEs might lead to patients therapy being stopped, causing reduced quality of life and even death.

Further research is needed to firstly, identify biomarkers (biological molecule found in blood, other body fluids, or tissues) that can be used as a sign to indicate that they will respond to the ICB therapy, which may enhance precision immunotherapy and improve patient outcomes. Secondly, the mechanisms underlying ICB resistance in patients who do not respond to ICB therapy are not well understood; combination strategies, where other therapies are used in combinations with ICB to reverse ICB resistance are not yet fully explored and could expand the population of patients who can benefit from ICB therapy. Thirdly, therapeutic targets and biomarkers for irAEs are urgently needed for monitoring ICB toxicity, in order to prevent severe immune-related adverse events (irAEs) and ensure safer treatment for patients.

This study will obtain biological features of ICB efficacy/toxicity group, search for potential factors related to  irAEs  and other prognostic indicators, and attempt to predict the outcome of ICB efficacy/toxicity in patients using machine learning methods
DOI: 10.15468/dl.yyvwej
title: Occurrence Download

description: A dataset containing 6520 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mercenaria mercenaria (Linnaeus, 1758)"
 ]
}

 The dataset includes 6520 records from 132 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021281-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14036155
title: Hassfurt Einhorn-Apotheke (ca. 1924/1947)

description: Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf. gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope): https://kalliope-verbund.info/DE-611-BF-70963 [Funktion: Im Findbuch anzeigen]Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht veröffentlicht werden dürfen).Historical
DOI: 10.5281/zenodo.14036156
title: Hassfurt Einhorn-Apotheke (ca. 1924/1947)

description: Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf. gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope): https://kalliope-verbund.info/DE-611-BF-70963 [Funktion: Im Findbuch anzeigen]Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht veröffentlicht werden dürfen).Historical
DOI: 10.15468/dl.wsrsny
title: Occurrence Download

description: A dataset containing 23623 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pueraria montana (Lour.) Merr."
 ]
}

 The dataset includes 23623 records from 404 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021283-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qvhj3y
title: Occurrence Download

description: A dataset containing 287 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pitar morrhuanus (Dall, 1902)"
 ]
}

 The dataset includes 287 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021284-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mxg7gw
title: Occurrence Download

description: A dataset containing 455343 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Phoenicopterus roseus Pallas, 1811"
 ]
}

 The dataset includes 455343 records from 344 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021262-241024112534372/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vyn3vg
title: Occurrence Download

description: A dataset containing 24789 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Opuntia ficus-indica (L.) Mill."
 ]
}

 The dataset includes 24789 records from 417 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007957-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8xqpsx
title: Occurrence Download

description: A dataset containing 10820 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pinus taeda L."
 ]
}

 The dataset includes 10820 records from 285 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007958-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rb8yvd
title: Occurrence Download

description: A dataset containing 77075 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lonicera japonica Thunb."
 ]
}

 The dataset includes 77075 records from 925 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007956-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dr62e5
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Linaria vulgaris Planellas"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007959-250127130748423/datasets/export for details.
DOI: 10.15468/dl.pc8hp6
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pinus taeda Blanco"
 ]
}

 The dataset includes 9 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007960-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fakt9m
title: Occurrence Download

description: A dataset containing 98 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lonicera japonica Thumb."
 ]
}

 The dataset includes 98 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007961-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xmuvx3
title: Occurrence Download

description: A dataset containing 88 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Occurrence evidence, Material sample)",
 "Country is one of (Myanmar, Thailand, Lao People’s Democratic Republic, Sri Lanka, Viet Nam, Nepal, India, unknown or invalid)",
 "OccurrenceStatus is Present",
 "TaxonKey is Manis pentadactyla Linnaeus, 1758"
 ]
}

 The dataset includes 88 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007962-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d4smgm
title: Occurrence Download

description: A dataset containing 237 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Linaria vulgaris Hill, 1756"
 ]
}

 The dataset includes 237 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007963-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25582/data.2024-02.3034847/2547640
title: Data for EMSL Project 60579 from February 2024
DOI: 10.25582/data.2024-02.3034848/2547641
title: Data for EMSL Project 60579 from February 2024
DOI: 10.25582/data.2024-02.3034849/2547642
title: Data for EMSL Project 60579 from February 2024
DOI: 10.15468/dl.ssmg87
title: Occurrence Download

description: A dataset containing 297 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is DEU.4_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Quercus robur L.",
 "Year 1982-2014"
 ]
}

 The dataset includes 297 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078526-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dmjqmq
title: Occurrence Download

description: A dataset containing 1634825 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Elasmobranchii"
 ]
}

 The dataset includes 1634825 records from 573 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003575-180412121330197/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b42kwh
title: Occurrence Download

description: A dataset containing 7989 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is United States of America",
 "HasCoordinate is true",
 "TaxonKey is Juniperus virginiana L.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 7989 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023009-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zf7xtj
title: Occurrence Download

description: A dataset containing 1534 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is VERTEBRADOS DE VALOR ESPECIAL EN ÁREAS PROTEGIDAS DE LA ARGENTINA",
 "TaxonKey is Tapirus terrestris (Linnaeus, 1758)"
 ]
}

 The dataset includes 1534 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002762-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kxekh4
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cola lissachensis Pellegr."
 ]
}

 The dataset includes 40 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003575-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vf4tww
title: Occurrence Download

description: A dataset containing 100 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brachyplatystoma platynemum Boulenger, 1898"
 ]
}

 The dataset includes 100 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005756-171025204727650/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vwf2gd
title: Occurrence Download

description: A dataset listing the 13958 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((100 26.5, 100.1 26.7, 99.7 26.6, 99.09999999999999 27.65, 99 28.7, 98.7 29.05, 98.40000000000001 29.95, 98.5 30.45, 98.2 30.8, 97.90000000000001 30.9, 97.90000000000001 31.15, 97.7 31.25, 97.7 31.5, 97.90000000000001 31.6, 97.95 32.2, 96.90000000000001 32.65, 96.65000000000001 33, 96.45 32.95, 96.09999999999999 33.25, 95.8 33.2, 95.2 33.45, 95.15000000000001 33.6, 94.8 33.55, 94.7 33.8, 94.25 33.65, 94.25 33.3, 93.84999999999999 33.3, 93.95 33.05, 94.40000000000001 33, 94.34999999999999 32.75, 94.59999999999999 32.75, 94.45 32.55, 93.95 32.45, 93.7 32.6, 93.5 32.45, 92.84999999999999 32.75, 92.2 32.75, 92.15000000000001 32.9, 91.90000000000001 32.85, 91.45 33.1, 91.40000000000001 33.3, 90.84999999999999 33.4, 90.55 34.1, 90.34999999999999 34.05, 90.15000000000001 34.4, 89.8 34.35, 89.8 34.9, 90.5 34.95, 91.05 34.75, 91.15000000000001 35.05, 90.8 35.3, 91.5 35.55, 91.59999999999999 35.35, 92.3 35.45, 93.40000000000001 35.35, 93.65000000000001 35.75, 94.59999999999999 35.6, 94.59999999999999 35.45, 95.15000000000001 35.4, 95.84999999999999 35.05, 96.15000000000001 34.55, 96.84999999999999 34.3, 97.2 33.95, 97.65000000000001 34.2, 97.75 33.85, 97.95 33.95, 98.45 33.85, 98.75 33.3, 99.05 33.35, 99.40000000000001 33.05, 100.35 33.35, 100.35 33.65, 100.95 33.25, 101.35 33.15, 101.5 33.25, 101.65 33.05, 102.05 32.95, 102.2 32.7, 102.15 32.3, 102.35 32.15, 102.5 32.45, 102.8 32.45, 102.95 32.85, 103.3 32.85, 103.4 33.05, 103 34, 102.6 34, 102.55 34.15, 102.7 34.25, 103.25 34.3, 103.55 34.15, 103.9 34.3, 104.05 34.15, 104.1 34.35, 104.35 34.4, 104.6 34.2, 105.1 34.5, 105.95 34.3, 106.35 34.45, 106.55 34.25, 107 34.25, 106.8 33.7, 106.2 33.6, 106.05 33.4, 105.5 33.4, 105.15 33.1, 105.15 32.75, 104.6 32.75, 104.75 32.4, 104.95 32.35, 104.75 31.65, 104.25 31.8, 103.9 31.65, 103.7 31.35, 103.45 31.5, 102.9 31.25, 102.9 30.9, 102.45 30.8, 102.4 30.25, 101.7 29.6, 101.7 29.2, 102 28.8, 101.95 28.15, 101.65 27.95, 101.75 27.4, 101.15 27, 100.65 27.15, 100.45 26.8, 100.6 26.45, 100.4 26.5, 100.1 26.25, 100 26.5))",
 "HasCoordinate is true",
 "Year is greater than or equal to 1960",
 "HasGeospatialIssue is false"
 ]
}

 The dataset's 13958 records were derived from 302 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050682-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.aiuqru
title: Occurrence Download

description: A dataset containing 1737 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Crocodylus acutus (Cuvier, 1807)"
 ]
}

 The dataset includes 1737 records from 70 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003575-180925134338326/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uv956c
title: Occurrence Download

description: A dataset containing 84 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Material sample"
 ]
 },
 "TaxonKey is Grammonus diagrammus (Heller & Snodgrass, 1903)"
 ]
}

 The dataset includes 84 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0042850-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.iucp5z
title: Occurrence Download

description: A dataset containing 396 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Canis lupus lycaon Schreber, 1775"
 ]
}

 The dataset includes 396 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002778-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gbss2t
title: Occurrence Download

description: A dataset containing 2152 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Andinobates Twomey, Brown, Amézquita & Mejía-Vargas, 2011"
 ]
}

 The dataset includes 2152 records from 59 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050399-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6bvvnq
title: Occurrence Download

description: A dataset containing 1901 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Raphia P.Beauv.",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1901 records from 96 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0077407-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.srpgwo
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Observation",
 "BasisOfRecord is Human Observation"
 ]
 },
 "Country is Mexico",
 "HasCoordinate is true",
 "TaxonKey is Inga vera Willd.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 28 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002766-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mz9sgb
title: Occurrence Download

description: A dataset containing 545 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Argentina",
 "Country is Chile"
 ]
 },
 "TaxonKey is Araucaria araucana (Molina) K.Koch"
 ]
}

 The dataset includes 545 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064590-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w8cj2h
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Narcissus christopheri",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017356-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5f43xs
title: Occurrence Download

description: A dataset containing 1170 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Leporinus fasciatus (Bloch, 1794)"
 ]
}

 The dataset includes 1170 records from 71 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0274686-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eqb7xw
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "and" : [
 "Year 1900-2020",
 "HasCoordinate is true",
 "TaxonKey is Acropora cervicornis (Lamarck, 1816)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset's 1 records were derived from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050406-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ryoth7
title: Occurrence Download

description: A dataset containing 21626 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Month is January",
 "HasCoordinate is true",
 "TaxonKey is Calidris ferruginea (Pontoppidan, 1763)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 21626 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005757-180412121330197/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.muytwz
title: Occurrence Download

description: A dataset containing 8942 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Urosaurus ornatus (Baird & Girard, 1852)",
 "HasCoordinate is True",
 "Country is United States of America",
 "Year is greater than or equal to 1960",
 "Year is less than or equal to 2020",
 "Month is greater than or equal to January",
 "Month is less than or equal to December",
 "HasGeospatialIssue is False",
 "DecimalLatitude is greater than or equal to 24.5",
 "DecimalLatitude is less than or equal to 49.5",
 "DecimalLongitude is greater than or equal to -125.0",
 "DecimalLongitude is less than or equal to -66.5"
 ]
}

 The dataset includes 8942 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0109489-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.953ba4
title: Occurrence Download

description: A dataset containing 996 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-121 32,-114 32,-114 37,-121 37,-121 32))",
 "HasCoordinate is true",
 "TaxonKey is Enhydra lutris (Linnaeus, 1758)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 996 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058346-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.re8j7z
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pycnophyllopsis cryptantha (Mattf.) M.Timana"
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005757-180824113759888/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.