cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.8146469
title: Context-dependent evolution of high trophic position drives functional disparity in subterranean crustaceans: data and R code

description: The dataset contains morphological data, phylogenetic tree, and R code used in the analyses presented in the paper titled "Context-dependent evolution of high trophic position drives functional disparity in subterranean crustaceans". Niphargus_morpho_data.xlsx: morphological data for import in R<br> Niphargus_tree.nex: consensus phylogenetic tree for import in R<br> Rcode.Rmd: the R script in R markdown format to reproduce the analyses<br> Rcode.html: the R script in html format <br> Reproducibility_report.doc: Functional diversity protocol checklist created with stepFD (https://facuxpalacio.shinyapps.io/stepFD/)
description: Funding: Slovenian Research and Innovation Agency (ARIS), core program funding (P1-0184), project (J1-2464) and PhD grants to ŠB and EP; University of Zurich Research Priority Programme on Global Change and Biodiversity URPP GCB (FA); University foundation of eng. Milan Lenarčič (EP). The equipment used in this study was purchased in the project "Development of Research Infrastructure For The International Competitiveness Of The Slovenian RRI Space –RI-SI-LifeWatch". The operation is co-financed by the Republic of Slovenia, Ministry of Education, Science and Sport and the European Union from the European Regional Development Fund.
DOI: 10.5281/zenodo.8146468
title: Context-dependent evolution of high trophic position drives functional disparity in subterranean crustaceans: data and R code

description: The dataset contains morphological data, phylogenetic tree, and R code used in the analyses presented in the paper titled "Context-dependent evolution of high trophic position drives functional disparity in subterranean crustaceans". Niphargus_morpho_data.xlsx: morphological data for import in R<br> Niphargus_tree.nex: consensus phylogenetic tree for import in R<br> Rcode.Rmd: the R script in R markdown format to reproduce the analyses<br> Rcode.html: the R script in html format <br> Reproducibility_report.doc: Functional diversity protocol checklist created with stepFD (https://facuxpalacio.shinyapps.io/stepFD/)
description: Funding: Slovenian Research and Innovation Agency (ARIS), core program funding (P1-0184), project (J1-2464) and PhD grants to ŠB and EP; University of Zurich Research Priority Programme on Global Change and Biodiversity URPP GCB (FA); University foundation of eng. Milan Lenarčič (EP). The equipment used in this study was purchased in the project "Development of Research Infrastructure For The International Competitiveness Of The Slovenian RRI Space –RI-SI-LifeWatch". The operation is co-financed by the Republic of Slovenia, Ministry of Education, Science and Sport and the European Union from the European Regional Development Fund.
DOI: 10.6084/m9.figshare.21394688
title: Real-world treatment patterns, costs, and outcomes in patients with AL amyloidosis: analysis of the Optum EHR and commercial claims databases

description: This study characterised real-world treatment patterns, clinical outcomes, and cost-of-illness in patients with light-chain (AL) amyloidosis. Data were extracted from the US-based Optum® EHR and Clinformatics® Data Mart (claims) databases (2008–2019) for patients newly diagnosed with AL amyloidosis and who initiated anti-plasma cell therapies. Healthcare resource utilisation (HCRU) and related costs were compared across lines of therapy (LOT). Incidences of cardiac and renal failure were evaluated using the Kaplan-Meier method. About 1347 patients (EHR, <i>n</i> = 776; claims, <i>n</i> = 571) were included. Median age was 68 years; 56.8% were male. At initial diagnosis, 33.1% and 15.1% of patients had cardiac and renal failure, respectively. Most patients received bortezomib-containing treatment in LOT1 (69%); bortezomib-cyclophosphamide-dexamethasone was most common (26%). HCRU was similar across LOTs. Mean per-patient-per-month and per-patient-per-LOT costs were $19,343 and $105,944 for LOT1, $19,183 and $95,793 for LOT2, and $16,611 and $128,446 for LOT3, respectively. Costs were primarily driven by anti-plasma cell therapies, outpatient visits, and hospitalisations. The 5-year cardiac and renal failure rates following initial diagnosis were 64.5% and 39.0%, respectively. AL amyloidosis is associated with substantial costs and suboptimal outcomes, highlighting the need for new therapeutic approaches to prevent organ deterioration, and reduce disease burden.
DOI: 10.6084/m9.figshare.21400488
title: An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis

description: The amyloidogenic transthyretin (TTR) variant, V122I, occurs in 4% of the African American population and frequently presents as a restricted cardiomyopathy. While heterozygosity for TTR V122I predominates, several compound heterozygous cases have been previously described. Herein, we detail features of ATTRv amyloidosis associated with novel compound heterozygous TTR mutation, T60I/V122I and provide evidence supporting the amyloidogenecity of T60I. A 63-year-old African American female presented with atrial fibrillation, congestive heart failure, autonomic and peripheral neuropathy. <i>In vitro</i> studies of TTR T60I and V122I were undertaken to compare the biophysical properties of the proteins. Congophilic deposits in a rectal biopsy were immunohistochemically positive for TTR. Serum screening by isoelectric focussing revealed two TTR variants in the absence of wild-type protein. DNA sequencing identified compound heterozygous <i>TTR</i> gene mutations, c.239C &gt; T and c.424G &gt; A. Adipose amyloid deposits were composed of both T60I and V122I. While kinetic stabilities of T60I and V122I variants were similar, distinct thermodynamic stabilities and amyloid growth kinetics were observed. This report provides clinical and experimental results supporting the amyloidogenic nature of a novel TTR T60I variant. <i>In vitro</i> data indicate that the destabilising effect of individual T60I and V122I variants appears to be additive rather than synergistic.
DOI: 10.6084/m9.figshare.21394392
title: Pulmonary function tests reveal unrecognised lung dysfunction and have independent prognostic significance in patients with systemic AL amyloidosis

description: Lung involvement in AL amyloidosis is not very common, but post-mortem data and retrospective studies suggest it is likely underrecognized. To perform a comprehensive evaluation of lung function with pulmonary function tests (PFTs) in patients with newly diagnosed AL amyloidosis. A prospective, non-interventional study of 139 consecutive patients with newly diagnosed AL amyloidosis. PFTs indicated normal breathing physiology in 68% of patients, obstructive in 9% and restrictive in 23%; the latter was associated with worse survival (28.6 vs 76 months for obstructive/normal physiology, <i>p</i> = 0.002) and remained significant after adjustment for Mayo stage and abnormal chest-CT. Forced vital capacity &lt;80% of predicted value, forced expiratory volume &lt;80% of predicted value, and carbon monoxide diffusion capacity &lt;70% were independently associated with poorer survival. Respiratory muscle strength (as assessed by maximal expiratory (Pe) and inspiratory (Pi) pressure) was affected in most patients (64% had Pi &lt; 55% and 57% had Pe &lt; 70% of predicted values). Pe% was an independent prognostic factor for survival (HR: 0.984 per 1% unit increase, <i>p</i> = 0.007). Pulmonary dysfunction, as assessed with PFTs, is common and underrecognized in patients with systemic AL amyloidosis, with significant prognostic and potentially therapeutic implications, independent of the degree of cardiac dysfunction or chest-CT findings.
DOI: 10.6084/m9.figshare.21394392.v1
title: Pulmonary function tests reveal unrecognised lung dysfunction and have independent prognostic significance in patients with systemic AL amyloidosis

description: Lung involvement in AL amyloidosis is not very common, but post-mortem data and retrospective studies suggest it is likely underrecognized. To perform a comprehensive evaluation of lung function with pulmonary function tests (PFTs) in patients with newly diagnosed AL amyloidosis. A prospective, non-interventional study of 139 consecutive patients with newly diagnosed AL amyloidosis. PFTs indicated normal breathing physiology in 68% of patients, obstructive in 9% and restrictive in 23%; the latter was associated with worse survival (28.6 vs 76 months for obstructive/normal physiology, <i>p</i> = 0.002) and remained significant after adjustment for Mayo stage and abnormal chest-CT. Forced vital capacity &lt;80% of predicted value, forced expiratory volume &lt;80% of predicted value, and carbon monoxide diffusion capacity &lt;70% were independently associated with poorer survival. Respiratory muscle strength (as assessed by maximal expiratory (Pe) and inspiratory (Pi) pressure) was affected in most patients (64% had Pi &lt; 55% and 57% had Pe &lt; 70% of predicted values). Pe% was an independent prognostic factor for survival (HR: 0.984 per 1% unit increase, <i>p</i> = 0.007). Pulmonary dysfunction, as assessed with PFTs, is common and underrecognized in patients with systemic AL amyloidosis, with significant prognostic and potentially therapeutic implications, independent of the degree of cardiac dysfunction or chest-CT findings.
DOI: 10.6084/m9.figshare.21394688.v1
title: Real-world treatment patterns, costs, and outcomes in patients with AL amyloidosis: analysis of the Optum EHR and commercial claims databases

description: This study characterised real-world treatment patterns, clinical outcomes, and cost-of-illness in patients with light-chain (AL) amyloidosis. Data were extracted from the US-based Optum® EHR and Clinformatics® Data Mart (claims) databases (2008–2019) for patients newly diagnosed with AL amyloidosis and who initiated anti-plasma cell therapies. Healthcare resource utilisation (HCRU) and related costs were compared across lines of therapy (LOT). Incidences of cardiac and renal failure were evaluated using the Kaplan-Meier method. About 1347 patients (EHR, <i>n</i> = 776; claims, <i>n</i> = 571) were included. Median age was 68 years; 56.8% were male. At initial diagnosis, 33.1% and 15.1% of patients had cardiac and renal failure, respectively. Most patients received bortezomib-containing treatment in LOT1 (69%); bortezomib-cyclophosphamide-dexamethasone was most common (26%). HCRU was similar across LOTs. Mean per-patient-per-month and per-patient-per-LOT costs were $19,343 and $105,944 for LOT1, $19,183 and $95,793 for LOT2, and $16,611 and $128,446 for LOT3, respectively. Costs were primarily driven by anti-plasma cell therapies, outpatient visits, and hospitalisations. The 5-year cardiac and renal failure rates following initial diagnosis were 64.5% and 39.0%, respectively. AL amyloidosis is associated with substantial costs and suboptimal outcomes, highlighting the need for new therapeutic approaches to prevent organ deterioration, and reduce disease burden.
DOI: 10.6084/m9.figshare.21400488.v1
title: An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis

description: The amyloidogenic transthyretin (TTR) variant, V122I, occurs in 4% of the African American population and frequently presents as a restricted cardiomyopathy. While heterozygosity for TTR V122I predominates, several compound heterozygous cases have been previously described. Herein, we detail features of ATTRv amyloidosis associated with novel compound heterozygous TTR mutation, T60I/V122I and provide evidence supporting the amyloidogenecity of T60I. A 63-year-old African American female presented with atrial fibrillation, congestive heart failure, autonomic and peripheral neuropathy. <i>In vitro</i> studies of TTR T60I and V122I were undertaken to compare the biophysical properties of the proteins. Congophilic deposits in a rectal biopsy were immunohistochemically positive for TTR. Serum screening by isoelectric focussing revealed two TTR variants in the absence of wild-type protein. DNA sequencing identified compound heterozygous <i>TTR</i> gene mutations, c.239C &gt; T and c.424G &gt; A. Adipose amyloid deposits were composed of both T60I and V122I. While kinetic stabilities of T60I and V122I variants were similar, distinct thermodynamic stabilities and amyloid growth kinetics were observed. This report provides clinical and experimental results supporting the amyloidogenic nature of a novel TTR T60I variant. <i>In vitro</i> data indicate that the destabilising effect of individual T60I and V122I variants appears to be additive rather than synergistic.
DOI: 10.5281/zenodo.8146499
title: Base de datos de artículos de la adicción a la tecnología y ansiedad en estudiantes

description: Artículos realizados con la base de datos Ebsco y Scielo, de artículos que estudiaron la adicción a la tecnología y ansiedad en estudiantes entre los años 2017 a 2023.
DOI: 10.5281/zenodo.8146498
title: Base de datos de artículos de la adicción a la tecnología y ansiedad en estudiantes

description: Artículos realizados con la base de datos Ebsco y Scielo, de artículos que estudiaron la adicción a la tecnología y ansiedad en estudiantes entre los años 2017 a 2023.
DOI: 10.5281/zenodo.8142270
title: LIFE Ilhas Barreira - D1 Project Milestone: Portfolio of UAV surveys database

description: The Ria Formosa Natural Park, a multi-barrier island system located in South Portugal, holds a variety of dune habitats of high ecological value. However, some of them are threatened by both human and natural pressures. An example are the grey dunes located at Barreta Island, which show clear signs of perturbation due to the settlement of two gull breeding colonies (west and east). The native grey dune vegetation coverage has been reduced within the nesting areas and replaced by ruderal species adapted to a higher nutrient content and gull physical disturbance (Talavera et al., 2022; Portela et al., 2023). Aiming to restore the native grey dune vegetation, the LIFE Ilhas Barreira project (LIFE18 NAT/PT/000927) implemented several conservation measures. Among them were the installation of gull control and exclusion areas in the two nesting areas (details on the materials and configuration of the exclusion and control areas can be found at Deliverable C2), which were monitored using a DJI Phantom 4 Multispectral drone during a 2-year period (December 2020-December 2022). The 5-band orthophotoimages available for download show the evolution of the vegetation coverage in these gull control and exclusion areas over the 2-year monitoring period.
description: This dataset is a deliverable of the LIFE project Ilhas Barreira: Conserving the Barrier Islands in Algarve to protect priority species and habitats (LIFE18 NAT/PT/000927), co-funded by the the European Commission LIFE programme.
DOI: 10.5281/zenodo.8142269
title: LIFE Ilhas Barreira - D1 Project Milestone: Portfolio of UAV surveys database

description: The Ria Formosa Natural Park, a multi-barrier island system located in South Portugal, holds a variety of dune habitats of high ecological value. However, some of them are threatened by both human and natural pressures. An example are the grey dunes located at Barreta Island, which show clear signs of perturbation due to the settlement of two gull breeding colonies (west and east). The native grey dune vegetation coverage has been reduced within the nesting areas and replaced by ruderal species adapted to a higher nutrient content and gull physical disturbance (Talavera et al., 2022; Portela et al., 2023). Aiming to restore the native grey dune vegetation, the LIFE Ilhas Barreira project (LIFE18 NAT/PT/000927) implemented several conservation measures. Among them were the installation of gull control and exclusion areas in the two nesting areas (details on the materials and configuration of the exclusion and control areas can be found at Deliverable C2), which were monitored using a DJI Phantom 4 Multispectral drone during a 2-year period (December 2020-December 2022). The 5-band orthophotoimages available for download show the evolution of the vegetation coverage in these gull control and exclusion areas over the 2-year monitoring period.
description: This dataset is a deliverable of the LIFE project Ilhas Barreira: Conserving the Barrier Islands in Algarve to protect priority species and habitats (LIFE18 NAT/PT/000927), co-funded by the the European Commission LIFE programme.
DOI: 10.34658/rdb.ozabba/n6reh4
title: Fig.9.jpg

description: :unav
DOI: 10.34658/rdb.ozabba/xewpl4
title: Fig.10.jpg

description: :unav
DOI: 10.5281/zenodo.8146510
title: Navigating the Complex Solid Form Landscape of the Quercetin Flavonoid Molecule

description: Data related to the paper published in Crystal Growth & Design, with doi:https://doi.org/10.1021/acs.cgd.3c00584. Quercetin, a naturally occurring bioflavonoid substance widely used in the nutraceutical and food industries, exists in various solid forms that can have different physicochemical properties, thus impacting this compound’s performance in various applications. In this work, we will clarify the complex solid-form landscape of this molecule. Two elusive isostructural solvates of quercetin were obtained from ethanol and methanol. The obtained crystals were characterized experimentally, but the crystallographic structure could not be solved due to their high instability. Nevertheless, the desolvated structure resulting from a high-temperature treatment (or prolonged storage at ambient conditions) of both these two labile crystals was characterized and solved via powder X-ray diffraction and solid-state nuclear magnetic resonance (SSNMR). This anhydrous crystal structure was compared with another anhydrous quercetin form obtained in our previous work, indicating that, at least, two different anhydrous polymorphs of quercetin exist. Navigating the solid-form landscape of quercetin is essential to ensure accurate control of the functional properties of food, nutraceutical, or pharmaceutical products containing crystal forms of this substance.
DOI: 10.34658/rdb.ozabba/ohgewd
title: Fig.6.jpg

description: :unav
DOI: 10.5281/zenodo.8146509
title: Navigating the Complex Solid Form Landscape of the Quercetin Flavonoid Molecule

description: Data related to the paper published in Crystal Growth & Design, with doi:https://doi.org/10.1021/acs.cgd.3c00584. Quercetin, a naturally occurring bioflavonoid substance widely used in the nutraceutical and food industries, exists in various solid forms that can have different physicochemical properties, thus impacting this compound’s performance in various applications. In this work, we will clarify the complex solid-form landscape of this molecule. Two elusive isostructural solvates of quercetin were obtained from ethanol and methanol. The obtained crystals were characterized experimentally, but the crystallographic structure could not be solved due to their high instability. Nevertheless, the desolvated structure resulting from a high-temperature treatment (or prolonged storage at ambient conditions) of both these two labile crystals was characterized and solved via powder X-ray diffraction and solid-state nuclear magnetic resonance (SSNMR). This anhydrous crystal structure was compared with another anhydrous quercetin form obtained in our previous work, indicating that, at least, two different anhydrous polymorphs of quercetin exist. Navigating the solid-form landscape of quercetin is essential to ensure accurate control of the functional properties of food, nutraceutical, or pharmaceutical products containing crystal forms of this substance.
DOI: 10.34658/rdb.ozabba/wmbphk
title: Fig.2a.jpg

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DOI: 10.34658/rdb.ozabba/iakgcb
title: Fig.2b.jpg

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DOI: 10.34658/rdb.ozabba/bsffvr
title: Fig.5b.jpg

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DOI: 10.34658/rdb.ozabba/my7p9d
title: Measured data M330-35.tab

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DOI: 10.34658/rdb.ozabba/nx1wgy
title: Fig.5a.jpg

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DOI: 10.34658/rdb.ozabba/tpzw9h
title: Comparison modeling vs measurements.tab

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DOI: 10.34658/rdb.ozabba/alhgya
title: Fig.8.jpg

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DOI: 10.34658/rdb.ozabba/co8ycd
title: Fig.4.jpg

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DOI: 10.34658/rdb.ozabba/xlepkx
title: Fig.7.jpg

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DOI: 10.6084/m9.figshare.23684484
title: GB-Score Files

description: All files for GB-Score.
DOI: 10.25403/upresearchdata.23671494
title: Analysis of livestock value chains

description: This dataset consists of an excel spreadsheet derived from Census of Commercial Agriculture (CoCA) 2018 as the study used secondary data. The spreadsheet was created to enable quantitative analysis that included simple descriptive statistics, hierarchical cluster analysis and multivariate analysis of variance on SPSS. It presents independent variables i.e. FMD red, free & protected zones against dependent variables such as livestock sales, livestock purchases, livestock retention, income from animals and animal products as well as agricultural land use in the different municipalities impacted by foot-and mouth disease in Limpopo, Mpumalanga and KwaZulu-Natal. The dataset mentions local municipalities and district regions found in three provinces mentioned and has grouped statistics according to these.
DOI: 10.25403/upresearchdata.23671494.v1
title: Analysis of livestock value chains

description: This dataset consists of an excel spreadsheet derived from Census of Commercial Agriculture (CoCA) 2018 as the study used secondary data. The spreadsheet was created to enable quantitative analysis that included simple descriptive statistics, hierarchical cluster analysis and multivariate analysis of variance on SPSS. It presents independent variables i.e. FMD red, free & protected zones against dependent variables such as livestock sales, livestock purchases, livestock retention, income from animals and animal products as well as agricultural land use in the different municipalities impacted by foot-and mouth disease in Limpopo, Mpumalanga and KwaZulu-Natal. The dataset mentions local municipalities and district regions found in three provinces mentioned and has grouped statistics according to these.