cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.30277360
title: Supporting data for "<i>ASXL1 </i>C-terminal truncation and <i>SRSF2</i> mutation drive leukemogenesis via immune reprogramming"

description: This dataset provides a comprehensive molecular resource for a study investigating the mechanisms of leukemia development using a genetically engineered zebrafish model. The research specifically focuses on the synergistic effects of mutations in the epigenetic regulator <i>asxl1</i> and the RNA splicing factor <i>SRSF2</i>, two genes frequently co-mutated in human myeloid malignancies. To recapitulate the disease, we generated zebrafish models harboring these mutations and performed an integrated analysis combining detailed phenotyping, histopathology, and multi-layered transcriptomic profiling. <b>The raw sequencing data for both bulk and single-cell RNA-seq have been deposited in the NCBI BioProject database under the accession number PRJNA1290872.</b>The data files contained within <b>this specific repository</b> represent the core processed and analytical outputs from this study. The <b>Bulk RNA-seq</b> analyses include spreadsheets identifying <b>differentially expressed genes</b> in double mutant fish compared to wildtype controls, which highlight key transcriptional changes driving leukemia. Furthermore, we provide files detailing <b>alternative spliced genes</b> and corresponding <b>Sashimi plots</b> to visualize the specific splicing events disrupted by the SRSF2 mutation. Complementing the bulk analysis, the <b>Single-cell RNA-seq (scRNA-seq)</b> data allows for the dissection of cellular heterogeneity within the leukemia model. This includes lists of <b>differentially expressed genes</b> across distinct cell populations, as well as the results of <b>Gene Set Variation Analysis (GSVA)</b>, which assesses the activity of specific biological pathways in single cells. A summary document is also included, synthesizing the key phenotypic and molecular findings into a consolidated overview.By making this dataset publicly available, we aim to provide the scientific community with a valuable resource to deepen the understanding of the molecular interplay between epigenetic and splicing dysregulation in leukemia, potentially informing future diagnostic and therapeutic strategies. All data is anonymized and free of sensitive information.
DOI: 10.25442/hku.30277360.v1
title: Supporting data for "<i>ASXL1 </i>C-terminal truncation and <i>SRSF2</i> mutation drive leukemogenesis via immune reprogramming"

description: This dataset provides a comprehensive molecular resource for a study investigating the mechanisms of leukemia development using a genetically engineered zebrafish model. The research specifically focuses on the synergistic effects of mutations in the epigenetic regulator <i>asxl1</i> and the RNA splicing factor <i>SRSF2</i>, two genes frequently co-mutated in human myeloid malignancies. To recapitulate the disease, we generated zebrafish models harboring these mutations and performed an integrated analysis combining detailed phenotyping, histopathology, and multi-layered transcriptomic profiling. <b>The raw sequencing data for both bulk and single-cell RNA-seq have been deposited in the NCBI BioProject database under the accession number PRJNA1290872.</b>The data files contained within <b>this specific repository</b> represent the core processed and analytical outputs from this study. The <b>Bulk RNA-seq</b> analyses include spreadsheets identifying <b>differentially expressed genes</b> in double mutant fish compared to wildtype controls, which highlight key transcriptional changes driving leukemia. Furthermore, we provide files detailing <b>alternative spliced genes</b> and corresponding <b>Sashimi plots</b> to visualize the specific splicing events disrupted by the SRSF2 mutation. Complementing the bulk analysis, the <b>Single-cell RNA-seq (scRNA-seq)</b> data allows for the dissection of cellular heterogeneity within the leukemia model. This includes lists of <b>differentially expressed genes</b> across distinct cell populations, as well as the results of <b>Gene Set Variation Analysis (GSVA)</b>, which assesses the activity of specific biological pathways in single cells. A summary document is also included, synthesizing the key phenotypic and molecular findings into a consolidated overview.By making this dataset publicly available, we aim to provide the scientific community with a valuable resource to deepen the understanding of the molecular interplay between epigenetic and splicing dysregulation in leukemia, potentially informing future diagnostic and therapeutic strategies. All data is anonymized and free of sensitive information.
DOI: 10.15468/dl.366bym
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"within","geometry":"POLYGON ((90.04916299999999 25.187541, 89.971568 25.181964, 89.895904 25.165372, 89.82405300000001 25.138176, 89.75779900000001 25.101055, 89.69878300000001 25.054929, 89.648459 25.000945, 89.608065 24.940439, 89.578585 24.874912, 89.56073000000001 24.805982, 89.55492099999999 24.73535, 89.56128099999999 24.664758, 89.579634 24.595942, 89.60950800000001 24.530591, 89.650156 24.47031, 89.70056700000001 24.416573, 89.759496 24.370695, 89.825497 24.333796, 89.896953 24.306778, 89.97211900000001 24.290299, 90.04916299999999 24.284762, 90.12620699999999 24.290299, 90.201373 24.306778, 90.272829 24.333796, 90.33883 24.370695, 90.39775899999999 24.416573, 90.44817 24.47031, 90.48881799999999 24.530591, 90.518692 24.595942, 90.53704500000001 24.664758, 90.54340500000001 24.73535, 90.53759599999999 24.805982, 90.519741 24.874912, 90.490261 24.940439, 90.449867 25.000945, 90.39954299999999 25.054929, 90.34052699999999 25.101055, 90.27427299999999 25.138176, 90.202422 25.165372, 90.126758 25.181964, 90.04916299999999 25.187541))"},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006612-260120142942310/datasets/export for details.
DOI: 10.5517/ccdc.csd.cc2dhfq2
title: CCDC 2219374: Experimental Crystal Structure Determination

description: Related Article: Luyao Wang, Mengqi Pei, Dongdong Sun, Jingjing Liu, Xie Han, Simin Liu|2025|Chin.Chem.Lett.||112221|doi:10.1016/j.cclet.2025.112221
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dhh7n
title: CCDC 2219421: Experimental Crystal Structure Determination

description: Related Article: Luyao Wang, Mengqi Pei, Dongdong Sun, Jingjing Liu, Xie Han, Simin Liu|2025|Chin.Chem.Lett.||112221|doi:10.1016/j.cclet.2025.112221
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dhhhx
title: CCDC 2219429: Experimental Crystal Structure Determination

description: Related Article: Luyao Wang, Mengqi Pei, Dongdong Sun, Jingjing Liu, Xie Han, Simin Liu|2025|Chin.Chem.Lett.||112221|doi:10.1016/j.cclet.2025.112221
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dhhn2
title: CCDC 2219434: Experimental Crystal Structure Determination

description: Related Article: Luyao Wang, Mengqi Pei, Dongdong Sun, Jingjing Liu, Xie Han, Simin Liu|2025|Chin.Chem.Lett.||112221|doi:10.1016/j.cclet.2025.112221
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2g1ry7
title: CCDC 2265819: Experimental Crystal Structure Determination

description: Related Article: Lin Li, Haibing Han, Yuying Fu, Jinjian Liu|2025|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01327
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gj90b
title: CCDC 2279771: Experimental Crystal Structure Determination

description: Related Article: Shuang-Cheng Li, Zi-Long Geng, Rui-Biao Fu, Zu-Ju Ma, Xin-Tao Wu|2024|Scripta Materialia|239|115824|doi:10.1016/j.scriptamat.2023.115824
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gmvts
title: CCDC 2283206: Experimental Crystal Structure Determination

description: Related Article: Hadi Kargar, Mehdi Fallah-Mehrjardi, Ersin Acar, Emine Berrin Poyraz, Necmi Dege, Khurram Shahzad Munawar|2024|J.Mol.Struct.|1318|139224|doi:10.1016/j.molstruc.2024.139224
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gntsr
title: CCDC 2284135: Experimental Crystal Structure Determination

description: Related Article: Hadi Kargar, Mehdi Fallah‑Mehrjardi, Khurram Shahzad Munawar, Ersin Acar, Necmi Dege, Sevgi Kansız|2025|J.Iran.Chem.Soc.|22|769|doi:10.1007/s13738-025-03184-1
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jx8d4
title: CCDC 2350866: Experimental Crystal Structure Determination

description: Related Article: Souvik Mukherjee, Sourav Ghosh, Keya Ghosh, Prasanta Ghosh|2025|Chem.Asian J.|20|e202401338|doi:10.1002/asia.202401338
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jx8f5
title: CCDC 2350867: Experimental Crystal Structure Determination

description: Related Article: Souvik Mukherjee, Sourav Ghosh, Keya Ghosh, Prasanta Ghosh|2025|Chem.Asian J.|20|e202401338|doi:10.1002/asia.202401338
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2k9jq4
title: CCDC 2362656: Experimental Crystal Structure Determination

description: Related Article: Luyao Wang, Mengqi Pei, Dongdong Sun, Jingjing Liu, Xie Han, Simin Liu|2025|Chin.Chem.Lett.||112221|doi:10.1016/j.cclet.2025.112221
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2jrvsy
title: CCDC 2346631: Experimental Crystal Structure Determination

description: Related Article: Milan Gumtya, Shamim Ahmad, Pradip Kumar Hansda, Suman Das, Surajit Singh, Debasish Haldar|2025|J.Mol.Struct.|1356||doi:10.1016/j.molstruc.2025.145183
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.47v5yf
title: Occurrence Download

description: A dataset containing 1225 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Nuphar advena",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 1225 records from 105 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006613-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2kh429
title: CCDC 2368030: Experimental Crystal Structure Determination

description: Related Article: Milan Gumtya, Shamim Ahmad, Pradip Kumar Hansda, Suman Das, Surajit Singh, Debasish Haldar|2025|J.Mol.Struct.|1356||doi:10.1016/j.molstruc.2025.145183
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kk7w8
title: CCDC 2370070: Experimental Crystal Structure Determination

description: Related Article: Alexia Marques Silva, Austin P. Lanquist, Curtis E. Moore, Randolph P. Thummel, Jeremy J. Kodanko, Claudia Turro|2025|J.Am.Chem.Soc.|||doi:10.1021/jacs.5c16353
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kk7x9
title: CCDC 2370071: Experimental Crystal Structure Determination

description: Related Article: Alexia Marques Silva, Austin P. Lanquist, Curtis E. Moore, Randolph P. Thummel, Jeremy J. Kodanko, Claudia Turro|2025|J.Am.Chem.Soc.|||doi:10.1021/jacs.5c16353
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2kry4f
title: CCDC 2376495: Experimental Crystal Structure Determination

description: Related Article: Souvik Mukherjee, Sourav Ghosh, Keya Ghosh, Prasanta Ghosh|2025|Chem.Asian J.|20|e202401338|doi:10.1002/asia.202401338
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2l6qj2
title: CCDC 2389744: Experimental Crystal Structure Determination

description: Related Article: Ganesh Shantaram Khomane, Tzu-Chun Yen, Gangababu Marri, Yi-Ru Chen, Pin-Ching Wang, Wenwei Lin|2025|Adv.Synth.Catal.|367|e70173|doi:10.1002/adsc.70173
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2llyqw
title: CCDC 2401499: Experimental Crystal Structure Determination

description: Related Article: Luying Song, Liming Wang, Renbo An, Wei Zhang, Ying Jin|2026|Asian J.Org.Chem|15|e70245|doi:10.1002/ajoc.70245
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lxsjv
title: CCDC 2410948: Experimental Crystal Structure Determination

description: Related Article: Xiumei Bai, Daria A. Ipatova, Dmitry A. Skvortsov, Vyacheslav A. Chertkov, Boris N. Tarasevich, Jinlei Bian, Yury V. Timchenko, Igor A. Rodin, Victor A. Tafeenko, Dmitry S. Yakovlev, Alexander A. Spasov, Raul I. Musaev, Nataliya A. Gurova, Jiayue Gao, Elena R. Milaeva, Elena K. Beloglazkina, Alexander V. Finko|2025|Med.Chem.Res.|34|1557|doi:10.1007/s00044-025-03427-z
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lxz0j
title: CCDC 2411118: Experimental Crystal Structure Determination

description: Related Article: Ziqiang Zhang, Wenbing Wang, Yating Shan, Quan Wang, Fuzhou Wang|2025|Chem. Sel.|10|e02948|doi:10.1002/slct.202502948
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mjjmb
title: CCDC 2428962: Experimental Crystal Structure Determination

description: Related Article: Priyanka Saha, Nicolas Chrysochos, Benedict J. Elvers, Siva Sankar Murthy Bandaru, Tejaswinee Gangber, Khyati Gaur, Ivo Krummenacher, Holger Braunschweig, Vadapalli Chandrasekhar, Prince Ravat, Carola Schulzke, Anukul Jana|2025|Chem.-Eur.J.|31|e02914|doi:10.1002/chem.202502914
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mjjpd
title: CCDC 2428964: Experimental Crystal Structure Determination

description: Related Article: Priyanka Saha, Nicolas Chrysochos, Benedict J. Elvers, Siva Sankar Murthy Bandaru, Tejaswinee Gangber, Khyati Gaur, Ivo Krummenacher, Holger Braunschweig, Vadapalli Chandrasekhar, Prince Ravat, Carola Schulzke, Anukul Jana|2025|Chem.-Eur.J.|31|e02914|doi:10.1002/chem.202502914
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n28np
title: CCDC 2445052: Experimental Crystal Structure Determination

description: Related Article: Shaoqiang Feng, Chengan Wan, Xiaoqiang Liang, Feng Zhang, Lei Feng, Chen Wen|2025|J.Mol.Struct.|||doi:10.1016/j.molstruc.2025.145184
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n96jq
title: CCDC 2451713: Experimental Crystal Structure Determination

description: Related Article: Zi-hang Yuan,Si-ya Zheng, Yu-mei Dai, En Tang
|2025|Appl.Organomet.Chem.|39||doi:10.1002/aoc.70363
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nrcyr
title: CCDC 2465335: Experimental Crystal Structure Determination

description: Related Article: Yu Zhang, Jialu Sun, Zhaojing Zheng, Yuankai Zhang, Hong Lu, Hao Wei|2025|Angew.Chem.,Int.Ed.|64|e20893|doi:10.1002/anie.202520893
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.