cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11407218.v1
title: Time-of-day variation on performance measures in repeated-sprint tests: a systematic review

description: The lack of standardization of methods and procedures have hindered agreement in the literature related to time-of-day effects on repeated sprint performance and needs clarification. Therefore, the aim of the present study was to investigate and systematically review the evidence relating to time-of-day based on performance measures in repeated-sprints. The entire content of PubMed (MEDLINE), Scopus, SPORTDiscus® (via EBSCOhost) and Web of Science was searched. Only experimental research studies conducted in male adult participants aged ≥18yrs, published in English before June 2019 were included. Studies assessing repeated-sprints between a minimum of two time-points during the day (morning versus evening) were deemed eligible. The primary search revealed that a total of 10 out of 112 articles were considered eligible and subsequently included. Seven articles were deemed strong and three moderate quality. Eight studies found repeated-sprint performance across the first, first few, or all sprints, to increase in favor of the evening. The magnitude of difference is dependent on the modality and the exercise protocol used. The non-motorized treadmill established an average 3.5–8.5% difference in distance covered, average and peak velocity, and average power, across all sprints in three studies and in peak power in two studies. In cycling, power output differed across all sprints by 6.0% in one study and 8.0% for the first sprint only in five studies. All four studies measuring power decrement values (i.e. rate of fatigue) established differences up to 4.0% and two out of five studies established total work to be significantly higher by 8.0%. Repeated-sprint performance is affected by time-of-day with greater performance in the late/early afternoon. The magnitude is dependent on the variable assessed and the mode of exercise. There is a clear demand for more rigorous investigations which control factors that specifically relate to investigations of time-of-day and are specific to the sport of individuals.
DOI: 10.6084/m9.figshare.11407122
title: Supplementary Figures and Tables from Drivers of future urban flood risk

description: The Source – Pathway – Receptor (SPR) framework used in analysing the drivers of flood risk, and the relationships with drivers, responses and impacts. Adapted from (Evans et al., 2008).;Foresight Futures. The vertical dimension shows the system of governance, ranging from autonomy, where power remains at the regional/national level, to interdependence, where power increasingly moves to other institutions. The horizontal dimension shows social values, ranging from individualistic values to community-oriented values. Source: (Evans et al., 2004).;The distribution of average annual damage from river and coastal flooding across England and Wales in the 2080s. The maps represent changes in risk by the 2080s for the four future scenarios. Darker shades of red signify progressively greater increases in damage. Green signifies a reduction. Red area under the ‘Local Stewardship’ scenario, and dark red areas under the other three scenarios coincide with urban conurbations. Grid size is 10 x 10 km. Source: (Evans et al., 2004).;The characteristics of the four future scenarios considered in the 2004, 2008 and this current review of the drivers of flood risk. Source: (Evans et al., 2004).;Drivers of fluvial and coastal flooding (note: drivers that are grey-tinted affect flood risk indirectly via other drivers). Source: (Evans et al., 2004).
DOI: 10.6084/m9.figshare.11407122.v1
title: Supplementary Figures and Tables from Drivers of future urban flood risk

description: The Source – Pathway – Receptor (SPR) framework used in analysing the drivers of flood risk, and the relationships with drivers, responses and impacts. Adapted from (Evans et al., 2008).;Foresight Futures. The vertical dimension shows the system of governance, ranging from autonomy, where power remains at the regional/national level, to interdependence, where power increasingly moves to other institutions. The horizontal dimension shows social values, ranging from individualistic values to community-oriented values. Source: (Evans et al., 2004).;The distribution of average annual damage from river and coastal flooding across England and Wales in the 2080s. The maps represent changes in risk by the 2080s for the four future scenarios. Darker shades of red signify progressively greater increases in damage. Green signifies a reduction. Red area under the ‘Local Stewardship’ scenario, and dark red areas under the other three scenarios coincide with urban conurbations. Grid size is 10 x 10 km. Source: (Evans et al., 2004).;The characteristics of the four future scenarios considered in the 2004, 2008 and this current review of the drivers of flood risk. Source: (Evans et al., 2004).;Drivers of fluvial and coastal flooding (note: drivers that are grey-tinted affect flood risk indirectly via other drivers). Source: (Evans et al., 2004).
DOI: 10.6084/m9.figshare.11407029
title: Supplementary Material for: Switching Biologics in the Treatment of Psoriasis: A Multicenter Experience

description: <b><i>Background/Objective:</i></b> The purpose of our study was to provide evidence on the treatment choices, reasons, and results of switching between biologic agents in treating patients with psoriasis. <b><i>Methods:</i></b> We conducted a retrospective database search of six tertiary referral centers for pso­riasis patients between January 2007 and May 2019. We analyzed patient and treatment characteristics of all patients in the registry. <b><i>Results:</i></b> We enrolled 427 psoriatic patients treated with biologics, and 145 (34%) required a switch to another biologic. The reasons for discontinuing the first biologic agent were inefficacy (<i>n</i> = 106, 62.4%), adverse events (<i>n</i> = 28, 16.5%), and others (<i>n</i> = 36, 21.2%). At week 12, there was a 67.7% reduction in the Psoriasis Area and Severity Index (PASI) score of patients treated with their first biologic, and 51.4% reduction for the second. A drug survival analysis showed no statistically significant difference between the drug survival of first-line biologic agents, but ustekinumab had the highest survival rate among second-line biologics (log-rank <i>p</i> = 0.010). Multivariate analyses for overall drug discontinuation showed that the occurrence of psoriatic arthritis (OR: 1.883, 95% CI: 1.274–2.782, <i>p</i> = 0.001), nail involvement (OR: 2.334, 95% CI: 1.534–3.552, <i>p</i> &lt; 0.001), and use of concomitant treatment (OR: 2.303, 95% CI: 1.403 –3.780, <i>p</i> = 0.001) are predictors for discontinuation. <b><i>Conclusion:</i></b> Discontinuation of treatment was most commonly due to inefficacy. Patients who switched to a different biologic agent showed a similar improvement in PASI scores compared to biologic-naive patients. Switching to a second biologic therapy due to inefficacy or adverse events caused by the first one may improve psoriasis.
DOI: 10.6084/m9.figshare.11407029.v1
title: Supplementary Material for: Switching Biologics in the Treatment of Psoriasis: A Multicenter Experience

description: <b><i>Background/Objective:</i></b> The purpose of our study was to provide evidence on the treatment choices, reasons, and results of switching between biologic agents in treating patients with psoriasis. <b><i>Methods:</i></b> We conducted a retrospective database search of six tertiary referral centers for pso­riasis patients between January 2007 and May 2019. We analyzed patient and treatment characteristics of all patients in the registry. <b><i>Results:</i></b> We enrolled 427 psoriatic patients treated with biologics, and 145 (34%) required a switch to another biologic. The reasons for discontinuing the first biologic agent were inefficacy (<i>n</i> = 106, 62.4%), adverse events (<i>n</i> = 28, 16.5%), and others (<i>n</i> = 36, 21.2%). At week 12, there was a 67.7% reduction in the Psoriasis Area and Severity Index (PASI) score of patients treated with their first biologic, and 51.4% reduction for the second. A drug survival analysis showed no statistically significant difference between the drug survival of first-line biologic agents, but ustekinumab had the highest survival rate among second-line biologics (log-rank <i>p</i> = 0.010). Multivariate analyses for overall drug discontinuation showed that the occurrence of psoriatic arthritis (OR: 1.883, 95% CI: 1.274–2.782, <i>p</i> = 0.001), nail involvement (OR: 2.334, 95% CI: 1.534–3.552, <i>p</i> &lt; 0.001), and use of concomitant treatment (OR: 2.303, 95% CI: 1.403 –3.780, <i>p</i> = 0.001) are predictors for discontinuation. <b><i>Conclusion:</i></b> Discontinuation of treatment was most commonly due to inefficacy. Patients who switched to a different biologic agent showed a similar improvement in PASI scores compared to biologic-naive patients. Switching to a second biologic therapy due to inefficacy or adverse events caused by the first one may improve psoriasis.
DOI: 10.6084/m9.figshare.11407014
title: Spreadsheet of confusion matrices (Open Document Spreadsheet)

description: ODS (Open Document Spreadsheet) which only contains numeric data from a set of confusion matrices (one sheet per matrix).<br>It is the same quantitative data stored in a field of a table in the database. Only is provided as a complement to the database in order to access to the quantitative data in a more convenient format.<br>
DOI: 10.6084/m9.figshare.11406957
title: Supplementary Material for: Utility of Dual Red Imaging for Endoscopic Hemostasis of Gastric Ulcer Bleeding

description: Dual red imaging (DRI; Red Dichromatic Imaging (RDI)) is a new type of image-enhanced endoscopy composed of two long wavelengths that together can visualize vessels in the deep submucosa of the gastrointestinal wall. We treated a case of gastric ulcer bleeding in which the bleeding point could be clearly visualized using DRI. A 71-year-old man who was taking warfarin for atrial fibrillation noticed tarry stool, entered a state of hypovolemic shock, and underwent emergency esophagogastroduodenoscopy. The procedure was performed with a GIF-Y0058 prototype endoscope (Olympus Co., Tokyo, Japan) equipped with a DRI mode. An ulcer with active bleeding was found in the upper portion of the stomach, but the massive volume of the bleeding made it difficult to identify the bleeding point using white light imaging (WLI). Upon switching to DRI mode by pushing a button on the endoscope, the bleeding point could be identified rapidly and precisely, as it appeared in a deeper yellow than the surrounding area. Complete hemostasis was thereupon achieved. This case demonstrates that the DRI mode may be useful for detecting bleeding points that are difficult to detect using WLI.
DOI: 10.6084/m9.figshare.11406957.v1
title: Supplementary Material for: Utility of Dual Red Imaging for Endoscopic Hemostasis of Gastric Ulcer Bleeding

description: Dual red imaging (DRI; Red Dichromatic Imaging (RDI)) is a new type of image-enhanced endoscopy composed of two long wavelengths that together can visualize vessels in the deep submucosa of the gastrointestinal wall. We treated a case of gastric ulcer bleeding in which the bleeding point could be clearly visualized using DRI. A 71-year-old man who was taking warfarin for atrial fibrillation noticed tarry stool, entered a state of hypovolemic shock, and underwent emergency esophagogastroduodenoscopy. The procedure was performed with a GIF-Y0058 prototype endoscope (Olympus Co., Tokyo, Japan) equipped with a DRI mode. An ulcer with active bleeding was found in the upper portion of the stomach, but the massive volume of the bleeding made it difficult to identify the bleeding point using white light imaging (WLI). Upon switching to DRI mode by pushing a button on the endoscope, the bleeding point could be identified rapidly and precisely, as it appeared in a deeper yellow than the surrounding area. Complete hemostasis was thereupon achieved. This case demonstrates that the DRI mode may be useful for detecting bleeding points that are difficult to detect using WLI.
DOI: 10.6084/m9.figshare.11407014.v1
title: ODS spreadsheet of confusion matrices

description: ODS (Open Document Spreadsheet) which only contains numeric data from a set of confusion matrices (one sheet per matrix).<br>It is the same quantitative data stored in a field of a table in the database. Only is provided as a complement to the database in order to access to the quantitative data in a more convenient format.<br>
DOI: 10.6084/m9.figshare.11406948
title: Supplementary Material for: The Mode of Detection Is Not Associated with Quality of Life in Women with Breast Cancer

description: <b><i>Introduction:</i></b> Apart from saving lives, mammography screening programs (MSP) are expected to reduce negative side effects of treatment by detecting cancer earlier, when it is more responsive to less aggressive treatment. This study compared quality of life (QoL) among women with breast cancers that were detected either by screening mammography, as interval cancers, or clinically among women not participating in the MSP. <b><i>Methods:</i></b> Retrospective study of first-ever invasive breast cancers detected among MSP-eligible women aged 50–69 years between 2006 and 2012 in Münster, Germany. EORTC QLQ-C30 and -BR23 questionnaires were mailed to 1,399 cases still alive in 2015 (response rate 64.1%). <b><i>Results:</i></b> Women’s responses were obtained on average 6.1 years after diagnosis. Mean crude and age-adjusted scores for overall QoL, breast and body image (BBI), and five functional scales (FS) were comparable between groups of detection mode. Clearly lower adjusted means for most scores were observed in women with interval cancers, if time since diagnosis was less than 5 years. Cases younger than 60 years showed lower values for some FS, particularly among interval and screen-detected cases. <b><i>Discussion/Conclusion:</i></b> In summary, cases with breast cancer showed health-related score values that were similar to the general population of the same age. There was also no indication that mode of detection markedly influenced these scores. However, after adjusting for tumor stage and other influential factors, screening participants appeared more susceptible to score declines after a diagnosis of cancer than non-participants.
DOI: 10.6084/m9.figshare.11406948.v1
title: Supplementary Material for: The Mode of Detection Is Not Associated with Quality of Life in Women with Breast Cancer

description: <b><i>Introduction:</i></b> Apart from saving lives, mammography screening programs (MSP) are expected to reduce negative side effects of treatment by detecting cancer earlier, when it is more responsive to less aggressive treatment. This study compared quality of life (QoL) among women with breast cancers that were detected either by screening mammography, as interval cancers, or clinically among women not participating in the MSP. <b><i>Methods:</i></b> Retrospective study of first-ever invasive breast cancers detected among MSP-eligible women aged 50–69 years between 2006 and 2012 in Münster, Germany. EORTC QLQ-C30 and -BR23 questionnaires were mailed to 1,399 cases still alive in 2015 (response rate 64.1%). <b><i>Results:</i></b> Women’s responses were obtained on average 6.1 years after diagnosis. Mean crude and age-adjusted scores for overall QoL, breast and body image (BBI), and five functional scales (FS) were comparable between groups of detection mode. Clearly lower adjusted means for most scores were observed in women with interval cancers, if time since diagnosis was less than 5 years. Cases younger than 60 years showed lower values for some FS, particularly among interval and screen-detected cases. <b><i>Discussion/Conclusion:</i></b> In summary, cases with breast cancer showed health-related score values that were similar to the general population of the same age. There was also no indication that mode of detection markedly influenced these scores. However, after adjusting for tumor stage and other influential factors, screening participants appeared more susceptible to score declines after a diagnosis of cancer than non-participants.
DOI: 10.6084/m9.figshare.11407014.v3
title: Spreadsheet of confusion matrices (Open Document Spreadsheet)

description: ODS (Open Document Spreadsheet) which only contains numeric data from a set of confusion matrices (one sheet per matrix).<br>It is the same quantitative data stored in a field of a table in the database. Only is provided as a complement to the database in order to access to the quantitative data in a more convenient format.<br>
DOI: 10.6084/m9.figshare.11407014.v2
title: Spreadsheet of confusion matrices (Open Document Spreadsheet)

description: ODS (Open Document Spreadsheet) which only contains numeric data from a set of confusion matrices (one sheet per matrix).<br>It is the same quantitative data stored in a field of a table in the database. Only is provided as a complement to the database in order to access to the quantitative data in a more convenient format.<br>
DOI: 10.6084/m9.figshare.11406888
title: Interaction between autonomous and microtubule guidance systems controls cellulose synthase trajectories Item

description: <b>The organisation of cellulose microfibrils is critical for the strength and growth of plant cell walls. Microtubules have been shown to play a key role in controlling microfibril organisation by guiding cellulose synthase complexes</b><b>. However, cellulose synthase trajectories can be maintained when microtubules are removed by drugs, suggesting a separate guidance mechanism is also at play</b><b>. By slowing down microtubule dynamics, we reveal such a mechanism by showing that cellulose synthase complexes can interact with the trails left by other complexes, causing them to follow the trails or disappear. The stability of the trails, together with the sensitivity of their directions to cellulase treatment, indicates they most likely reflect nascent cellulose microfibrils. Over many hours, this autonomous mechanism alone can lead to a change in the dominant orientation of cellulose synthase trajectories. However, the mechanism can be overridden by the microtubule guidance system. Our findings suggest a dual guidance model, in which an autonomous system, involving interaction between cellulose synthases and microfibrils, can maintain aligned cellulose synthase trajectories, while a microtubule guidance system allows alignments to be steered by environmental and developmental cues. </b>
DOI: 10.6084/m9.figshare.11406912
title: Shared data for JGR

description: This is a compressed package including WRF simulation data (annual),CMORPH data(daily) and FNL data (daily).
DOI: 10.6084/m9.figshare.11406885
title: Supplementary Material for: Machine Learning Prediction of Radiofrequency Thermal Ablation Efficacy: A New Option to Optimize Thyroid Nodule Selection

description: <b><i>Background:</i></b> Radiofrequency (RF) is a therapeutic modality for reducing the volume of large benign thyroid nodules. If thermal therapies are interpreted as an alternative strategy to surgery, critical issues in their use are represented by the extent of nodule reduction and by the durability of nodule reduction over a long period of time. <b><i>Objective:</i></b> To assess the ability of machine learning to discriminate nodules with volume reduction rate (VRR) &lt; or ≥50% at 12 months following RF treatment. <b><i>Methods:</i></b> A machine learning model was trained with a dataset of 402 cytologically benign thyroid nodules subjected to RF at six Italian Institutions. The model was trained with the following variables: baseline nodule volume, echostructure, macrocalcalcifications, vascularity, and 12-month VRR. <b><i>Results:</i></b> After training, the model could distinguish between nodules having VRR &lt;50% from those having VRR ≥50% in 85% of cases (accuracy: 0.85; 95% confidence interval [CI]: 0.80–0.90; sensitivity: 0.70; 95% CI: 0.62–0.75; specificity: 0.99; 95% CI: 0.98–1.0; positive predictive value: 0.95; 95% CI: 0.92–0.98; negative predictive value: 0.95; 95% CI: 0.92–0.98). <b><i>Conclusions:</i></b> This study demonstrates that a machine learning model can reliably identify those nodules that will have VRR &lt; or ≥50% at 12 months after one RF treatment session. Predicting which nodules will be poor or good responders represents valuable data that may help physicians and patients decide on the best treatment option between thermal ablation and surgery or in predicting if more than one session might be necessary to obtain a significant volume reduction.
DOI: 10.6084/m9.figshare.11406888.v1
title: Interaction between autonomous and microtubule guidance systems controls cellulose synthase trajectories Item

description: <b>The organisation of cellulose microfibrils is critical for the strength and growth of plant cell walls. Microtubules have been shown to play a key role in controlling microfibril organisation by guiding cellulose synthase complexes</b><b>. However, cellulose synthase trajectories can be maintained when microtubules are removed by drugs, suggesting a separate guidance mechanism is also at play</b><b>. By slowing down microtubule dynamics, we reveal such a mechanism by showing that cellulose synthase complexes can interact with the trails left by other complexes, causing them to follow the trails or disappear. The stability of the trails, together with the sensitivity of their directions to cellulase treatment, indicates they most likely reflect nascent cellulose microfibrils. Over many hours, this autonomous mechanism alone can lead to a change in the dominant orientation of cellulose synthase trajectories. However, the mechanism can be overridden by the microtubule guidance system. Our findings suggest a dual guidance model, in which an autonomous system, involving interaction between cellulose synthases and microfibrils, can maintain aligned cellulose synthase trajectories, while a microtubule guidance system allows alignments to be steered by environmental and developmental cues. </b>
DOI: 10.6084/m9.figshare.11406912.v2
title: Shared data for JGR

description: This is a compressed package including WRF simulation data (annual),CMORPH data(daily) and FNL data (daily).