cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48432/sq7vsp/i9tgba
title: Filizola_et_alcsv.tab

description: :unav
DOI: 10.48432/sq7vsp
title: Atributos físico-hídricos e estoque de carbono de solos de áreas sob irrigação em Itaí, SP

description: Os dados aqui disponibilizados foram usados para avaliar e comparar atributos físico-hídricos de solos de duas microbacias hidrográficas (MBH) de primeira ordem cultivadas com plantio direto (PD), sob irrigação por pivô central, em Itaí/SP, para estimar a condição das áreas de cultura. Foram avaliados os solos de 15 pontos amostrais, distribuídos nos terços Superior, Médio e Inferior da vertente de cada uma das MBH, sendo as coletas realizadas em 5 pontos distanciados numa mesma cota, ao longo de cada terço da vertente. O trabalho teve como objetivo apresentar e discutir comparativamente resultados de alguns parâmetros físicos, do teor de carbono e estoque deste último, em dois Latossolos Vermelhos Distróficos típicos. Os sistemas diferiam porque, entre 2012 e 2015, a sequência de culturas na MBH1 foi: trigo/algodão – feijão/soja – trigo/soja e na MBH2 a sequência foi composta por feijão/milho - feijão/milho - trigo/algodão. A qualidade do manejo foi avaliada pelo índice de qualidade participativo do plantio direto (IQP), proposto por Roloff, Lutz e Mello (2011). Na MBH2 o IQP foi de 6,9, levemente superior ao da MBH1 cujo IQP foi de 5,6, sendo que, nesta última, a ocorrência de erosão é bem mais evidente. Assim, considerou-se que o manejo adotado na MBH2 de melhor qualidade e o da MBH1 de qualidade relativamente inferior. Os locais de coletas estão situados no município de Itaí, sudoeste do estado de São Paulo, Brasil. A microbacia hidrográfica 1 (MBH1) localiza-se em 23°33’41,94"S e 49°04'50,34"W, a uma altitude de 649 m com relevo ondulado e vertente convexa. A microbacia hidrográfica 2 (MBH2) localiza-se a 23°35'00,35" S e 48°56'21,35" W a uma altitude de 703 m. Nesta MBH, o relevo é suave a suave ondulado e vertente côncava. A MBH1 apresenta relevo ondulado e vertente convexa; em todo o perfil a textura do solo é muito argilosa (700 g kg-1). Já, na MBH2 a textura é argilosa (515 g kg-1) na camada superficial e muito argilosa (600 g kg-1) em subsuperfície. Em ambas MBH, ocorre um horizonte epieutrófico devido a fertilização e calagem. O solo coletado foi enviado aos laboratórios da Embrapa Meio Ambiente para a avaliação das classes texturais, diâmetro médio ponderado (DMP), densidade aparente do solo (Ds), porosidade total, macroporosidade, argila dispersa em água (ADA) e carbono orgânico. As diferenças mais marcantes entre as duas áreas foram o teor de argila dispersa em água, a macroporosidade, assim como o estoque de carbono no solo.
DOI: 10.5281/zenodo.7035253
title: Zenodo Upload for DataFed record:YG044_Yichen_Guo_07172022

description: Zenodo Upload for DataFed record:YG044_Yichen_Guo_07172022
DOI: 10.5281/zenodo.7035252
title: Zenodo Upload for DataFed record:YG044_Yichen_Guo_07172022

description: Zenodo Upload for DataFed record:YG044_Yichen_Guo_07172022
DOI: 10.5281/zenodo.5079910
title: The phenotypic plasticity of an evolving digital organism

description: Data set and R code used in the analysis reported in the manuscript entitled "<em>The phenotypic plasticity of an evolving digital organism</em>", which has been accepted in Proc. R. Open. Sci. for publication.
description: https://gitlab.com/fortunalab/publications/phenotypic-plasticity-of-an-evolving-digital-organism
DOI: 10.25934/pr00005729.3
title: Available IPD datapackage for study 'A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Pertuzumab + Trastuzumab + Docetaxel vs. Placebo + Trastuzumab + Docetaxel in Previously Untreated HER2-Positive Metastatic Breast Cancer'

description: This study was a Phase III, randomized, double-blind, placebo-controlled, multicenter international clinical trial conducted to investigate the use of pertuzumab in combination with trastuzumab and docetaxel as first-line treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC). Participants could have received one prior hormonal treatment for MBC. Participants may have received systemic breast cancer treatment in the neo-adjuvant or adjuvant setting, provided that the participant had experienced a disease-free interval (DFI) of greater than or equal to (≥)12 months from completion of adjuvant systemic treatment (excluding hormonal therapy) to metastatic diagnosis. Participants may have received trastuzumab and/or a taxane during the neo-adjuvant or adjuvant treatment. Participants were randomized in 1:1 ratio to receive either pertuzumab or placebo, along with trastuzumab and docetaxel once every 3 weeks (q3w), during the treatment phase of the study until investigator-assessed radiographic or clinical progressive disease, unmanageable toxicity, or study termination. Participants in the Placebo arm were not allowed to receive open-label pertuzumab after discontinuation from study treatment. However, if any analysis of overall survival had met the predefined criteria for statistical significance, participants in the Placebo arm still on treatment were offered the option to receive open-label pertuzumab in addition to other study medications.
DOI: 10.5281/zenodo.6846628
title: Merging Morphological and Genetic Evidence to assess hybridization in Eurasian Late Pleistocene hominins

description: <pre>Previous scientific consensus saw human evolution as defined by adaptive differences (behavioural and/or biological) and the emergence of Homo sapiens as the ultimate replacement of non-modern groups by a modern, adaptively more competitive one. However, recent research has shown that the process underlying our origins was considerably more complex. While archaeological and fossil evidence suggests that behavioural complexity may not be confined to the modern human lineage, recent paleogenomic work shows that gene flow between distinct lineages (e.g., Neanderthals, Denisovans, early H. sapiens) occurred repeatedly in the Late Pleistocene, likely contributing elements to our genetic make-up that might have been crucial to our success as a diverse, adaptable species. Following these advances, the prevailing human origins model has shifted from one of near-complete replacement to a more nuanced view of partial replacement with considerable reticulation. Here we provide a brief introduction to the current genetic evidence for hybridization among hominins, its prevalence in, and effects on, comparative mammal groups, and especially how it manifests in the skull. We then explore the degree to which cranial variation seen in the fossil record of Late Pleistocene hominins from Western Eurasia corresponds with our current genetic and comparative data. We are especially interested in understanding the degree to which skeletal data can reflect admixture. Our findings indicate some correspondence between these different lines of evidence, flag individual fossils as possibly admixed, and suggest that different cranial regions may preserve hybridisation signals differentially. We urge further studies of the phenotype in order to expand our ability to detect the ways in which migration, interaction and genetic exchange have shaped the human past, beyond what is currently visible with the lens of ancient DNA. </pre>
DOI: 10.5281/zenodo.6846627
title: Merging Morphological and Genetic Evidence to assess hybridization in Eurasian Late Pleistocene hominins

description: <pre>Previous scientific consensus saw human evolution as defined by adaptive differences (behavioural and/or biological) and the emergence of Homo sapiens as the ultimate replacement of non-modern groups by a modern, adaptively more competitive one. However, recent research has shown that the process underlying our origins was considerably more complex. While archaeological and fossil evidence suggests that behavioural complexity may not be confined to the modern human lineage, recent paleogenomic work shows that gene flow between distinct lineages (e.g., Neanderthals, Denisovans, early H. sapiens) occurred repeatedly in the Late Pleistocene, likely contributing elements to our genetic make-up that might have been crucial to our success as a diverse, adaptable species. Following these advances, the prevailing human origins model has shifted from one of near-complete replacement to a more nuanced view of partial replacement with considerable reticulation. Here we provide a brief introduction to the current genetic evidence for hybridization among hominins, its prevalence in, and effects on, comparative mammal groups, and especially how it manifests in the skull. We then explore the degree to which cranial variation seen in the fossil record of Late Pleistocene hominins from Western Eurasia corresponds with our current genetic and comparative data. We are especially interested in understanding the degree to which skeletal data can reflect admixture. Our findings indicate some correspondence between these different lines of evidence, flag individual fossils as possibly admixed, and suggest that different cranial regions may preserve hybridisation signals differentially. We urge further studies of the phenotype in order to expand our ability to detect the ways in which migration, interaction and genetic exchange have shaped the human past, beyond what is currently visible with the lens of ancient DNA. </pre>
DOI: 10.6084/m9.figshare.19549495
title: Comparative genomics of "Candidatus Nanohaloarchaeota"

description: These are the raw data, scripts, and supplementary materials for the manuscript <strong>Comparative genomic insights into the evolution of </strong><em><strong>Halobacteria</strong></em><strong>-associated "</strong><em><strong>Candidatus</strong></em><strong> Nanohaloarchaeota"</strong>.
DOI: 10.6084/m9.figshare.19549495.v4
title: Comparative genomics of "Candidatus Nanohaloarchaeota"

description: These are the raw data, scripts, and supplementary materials for the manuscript <strong>Comparative genomic insights into the evolution of </strong><em><strong>Halobacteria</strong></em><strong>-associated "</strong><em><strong>Candidatus</strong></em><strong> Nanohaloarchaeota"</strong>.
DOI: 10.6084/m9.figshare.19549495.v3
title: Comparative genomics of "Candidatus Nanohaloarchaeota"

description: These are the raw data, scripts, and supplementary materials for the manuscript <strong>Comparative genomic insights into the evolution of </strong><em><strong>Halobacteria</strong></em><strong>-associated "</strong><em><strong>Candidatus</strong></em><strong> Nanohaloarchaeota"</strong>.
DOI: 10.6084/m9.figshare.20043374.v12
title: DDXPlus Dataset

description: We are releasing under the CC-BY licence a new large-scale dataset for Automatic Symptom Detection (ASD) and Automatic Diagnosis (AD) systems in the medical domain. The dataset contains patients synthesized using a proprietary medical knowledge base and a commercial rule-based AD system. Patients in the dataset are characterized by their socio-demographic data, a pathology they are suffering from, a set of symptoms and antecedents related to this pathology, and a differential diagnosis. The symptoms and antecedents can be binary, categorical and multi-choice, with the potential of leading to more efficient and natural interactions between ASD/AD systems and patients. To the best of our knowledge, this is the first large-scale dataset that includes the differential diagnosis, and non-binary symptoms and antecedents.
DOI: 10.5281/zenodo.7030983
title: Local structure and density of liquid Fe-C-S alloys at Moon's core conditions

description: This file includes the raw CAESAR and absorption data measured in each P-T condition and the Python codes for diffraction and absorption data analysis. Matlab codes for P-T calibration are also enclosed.
DOI: 10.6084/m9.figshare.20732512
title: Simulated logs

description: There are 21 event logs generated using the 21 process model in https://figshare.com/articles/dataset/_/20732095. The logs are available in mxml and csv formats
DOI: 10.6084/m9.figshare.20732215
title: Process models in Petri net

description: 21 process models as Petri net models
DOI: 10.6084/m9.figshare.20732215.v1
title: Process models in Petri net

description: 21 process models as Petri net models
DOI: 10.5517/ccdc.csd.cc2c86sn
title: CCDC 2182641: Experimental Crystal Structure Determination

description: Related Article: Alexandra S. Antonova, Eugeniya V. Nikitina, Karina S. Valchuk, Mikhail S. Grigoriev, Rosa M. Gomila, Antonio Frontera, Fedor I. Zubkov|2022|CrystEngComm|24|6093|doi:10.1039/D2CE00903J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.20732095
title: Process model simulated scenarios (BPMN)

description: The dataset contains 21 process models with a variety in process structure and behavior. These models also have the simulation parameters to simulate the process using BIMP (https://bimp.cs.ut.ee/)
DOI: 10.6084/m9.figshare.20732248
title: SUPPLEMENTARY TABLE 3.xlsx

description: Supplementary Table 3.
DOI: 10.6084/m9.figshare.20732248.v1
title: SUPPLEMENTARY TABLE 3.xlsx

description: Supplementary Table 3.
DOI: 10.6084/m9.figshare.20732248.v2
title: SUPPLEMENTARY TABLE 3.xlsx

description: Supplementary Table 3.
DOI: 10.21410/7e4/mqqjxo
title: Fonds Federico Tarragoni

description: Le fonds a été produit lors de la réalisation de la thèse de doctorat au sein de Université Paris 10 Nanterre, laboratoire IDHES, sous la direction de M Patrick Cingolani. Le titre du projet était « Il faut faire le peuple : sociologie d’un populisme par le bas au Venezuela et en Bolivie ». Ce projet a conduit le producteur à réaliser une campagne d’enquêtes en Amérique du Sud, pendant trois séjours de recherche pour la réalisation d’études sur le terrain : deux séjours en Venezuela (janvier-mai 2007, 2011), un en Bolivie (entre 2010 et 2011).
DOI: 10.25574/49825
title: Chandra X-ray Observatory ObsId 49825
DOI: 10.25574/49838
title: Chandra X-ray Observatory ObsId 49838
DOI: 10.25574/49843
title: Chandra X-ray Observatory ObsId 49843
DOI: 10.25574/49854
title: Chandra X-ray Observatory ObsId 49854
DOI: 10.25574/49859
title: Chandra X-ray Observatory ObsId 49859
DOI: 10.25574/49865
title: Chandra X-ray Observatory ObsId 49865
DOI: 10.25574/49871
title: Chandra X-ray Observatory ObsId 49871
DOI: 10.25574/49877
title: Chandra X-ray Observatory ObsId 49877
DOI: 10.25574/49882
title: Chandra X-ray Observatory ObsId 49882
DOI: 10.25919/2rdp-3p51
title: Parkes observations for project P1021 semester 2022APRS_04

description: We propose to continue our observations of PSR J1653-4518 and PSR J1812-15, a pair of long spin-period binary pulsars which both show degrees of orbitally-dependent variability. Binary pulsars are valuable objects of scientific study, allowing for multiple applications including tests of gravity, probes of the neutron star equation of state, and fossil records of stellar evolution. Long spin-period pulsars in binary systems are generally much rarer than faster-spinning `recycled’ pulsars, and represent an under-explored region of pulsar binary evolution. This is particularly true of PSR J1812-15, for which only one other pulsar (B1718-19) seems remotely comparable. Based on previous Parkes proposals, our understanding of these pulsars has significantly increased (including the development of a timing solution for PSR J1653-4518), such that we anticipate their publication in early 2022. However, a minimal low-cadence timing campaign is still required to pursue lingering questions regarding both pulsars. For PSR J1812-15, this data is required to address ongoing problems with phase connection, which may be caused by an undiagnosed glitch or other un-modelled timing effect. For PSR J1653-4518, this data is required to maintain phase-connection in support of a multifrequency observing campaign targeting high-frequency emission during the pulsar’s next anticipated eclipse in November 2022 (an effect seen in similar binary systems). These observations will set up additional publishable results beyond the anticipated near-term publications in early 2022.
DOI: 10.25574/49888
title: Chandra X-ray Observatory ObsId 49888
DOI: 10.25574/49894
title: Chandra X-ray Observatory ObsId 49894
DOI: 10.25574/49896
title: Chandra X-ray Observatory ObsId 49896

description: HIGH RESOLUTION X-RAY SPECTRA OF CLUSTER COOLING FLOWS
DOI: 10.25574/49905
title: Chandra X-ray Observatory ObsId 49905
DOI: 10.25574/49911
title: Chandra X-ray Observatory ObsId 49911
DOI: 10.25574/49917
title: Chandra X-ray Observatory ObsId 49917
DOI: 10.25574/49925
title: Chandra X-ray Observatory ObsId 49925
DOI: 10.25574/49933
title: Chandra X-ray Observatory ObsId 49933
DOI: 10.25574/49940
title: Chandra X-ray Observatory ObsId 49940
DOI: 10.25574/49946
title: Chandra X-ray Observatory ObsId 49946
DOI: 10.25574/49965
title: Chandra X-ray Observatory ObsId 49965
DOI: 10.25574/49973
title: Chandra X-ray Observatory ObsId 49973
DOI: 10.25574/49979
title: Chandra X-ray Observatory ObsId 49979
DOI: 10.25574/49985
title: Chandra X-ray Observatory ObsId 49985
DOI: 10.25574/49991
title: Chandra X-ray Observatory ObsId 49991
DOI: 10.25574/49999
title: Chandra X-ray Observatory ObsId 49999
DOI: 10.5281/zenodo.7032072
title: Dataset of "Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinityincreased CD8 T lymphocytes"

description: <strong>Background</strong>: Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studies have focused on T cell responses to antigen-specific stimulation. In contrast, little is known on the regulation of T cell responsiveness through continuous TCR triggering and consequent tonic signaling. Here, we addressed the question whether increasing the TCR affinity can lead to chronic interactions occurring directly between TCRs and MHC-(self) molecules, which may modulate the overall functional potency of tumor-redirected CD8 T cells. For this purpose, we developed two complementary human CD8 T cell models (i.e. HLA-A2 knock-in and knock-out) engineered with incremental-affinity TCRs to the HLA-A2/NY-ESO-1 tumor antigen.<br> <strong>Methods</strong>: The impact of HLA-A2 recognition, depending on TCR affinity, was assessed at the levels of the TCR/CD3 complex, regulatory receptors, and signaling, under steady-state conditions and in kinetic studies. The quality of<br> CD8 T cell responses was further evaluated by gene expression and multiplex cytokine profiling, as well as real-time quantitative cell killing, combined with co-culture assays.<br> <strong>Results</strong>: We found that HLA-A2 per se (in absence of cognate peptide) can trigger chronic activation followed by a tolerance-like state of tumor-redirected CD8 T cells with increased-affinity TCRs. HLA-A2pos but not HLA-A2neg T cells displayed an activation phenotype, associated with enhanced upregulation of c-CBL and multiple inhibitory receptors. T cell activation preceded TCR/CD3 downmodulation, impaired TCR signaling and functional<br> hyporesponsiveness. This stepwise activation-to-hyporesponsive state was dependent on TCR affinity and already detectable at the upper end of the physiological affinity range (KD ≤ 1 μM). Similar findings were made when<br> affinity-increased HLA-A2neg CD8 T cells were chronically exposed to HLA-A2pos-expressing target cells.<br> <strong>Conclusions</strong>: Our observations indicate that sustained interactions between affinity-increased TCR and self-MHC can directly adjust the functional potential of T cells, even in the absence of antigen-specific stimulation. The<br> observed tolerance-like state depends on TCR affinity and has therefore potential implications for the design of affinity-improved TCRs for adoptive T cell therapy, as several engineered TCRs currently used in clinical trials share<br> similar affinity properties.
DOI: 10.5281/zenodo.7032073
title: Dataset of "Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinityincreased CD8 T lymphocytes"

description: <strong>Background</strong>: Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studies have focused on T cell responses to antigen-specific stimulation. In contrast, little is known on the regulation of T cell responsiveness through continuous TCR triggering and consequent tonic signaling. Here, we addressed the question whether increasing the TCR affinity can lead to chronic interactions occurring directly between TCRs and MHC-(self) molecules, which may modulate the overall functional potency of tumor-redirected CD8 T cells. For this purpose, we developed two complementary human CD8 T cell models (i.e. HLA-A2 knock-in and knock-out) engineered with incremental-affinity TCRs to the HLA-A2/NY-ESO-1 tumor antigen.<br> <strong>Methods</strong>: The impact of HLA-A2 recognition, depending on TCR affinity, was assessed at the levels of the TCR/CD3 complex, regulatory receptors, and signaling, under steady-state conditions and in kinetic studies. The quality of<br> CD8 T cell responses was further evaluated by gene expression and multiplex cytokine profiling, as well as real-time quantitative cell killing, combined with co-culture assays.<br> <strong>Results</strong>: We found that HLA-A2 per se (in absence of cognate peptide) can trigger chronic activation followed by a tolerance-like state of tumor-redirected CD8 T cells with increased-affinity TCRs. HLA-A2pos but not HLA-A2neg T cells displayed an activation phenotype, associated with enhanced upregulation of c-CBL and multiple inhibitory receptors. T cell activation preceded TCR/CD3 downmodulation, impaired TCR signaling and functional<br> hyporesponsiveness. This stepwise activation-to-hyporesponsive state was dependent on TCR affinity and already detectable at the upper end of the physiological affinity range (KD ≤ 1 μM). Similar findings were made when<br> affinity-increased HLA-A2neg CD8 T cells were chronically exposed to HLA-A2pos-expressing target cells.<br> <strong>Conclusions</strong>: Our observations indicate that sustained interactions between affinity-increased TCR and self-MHC can directly adjust the functional potential of T cells, even in the absence of antigen-specific stimulation. The<br> observed tolerance-like state depends on TCR affinity and has therefore potential implications for the design of affinity-improved TCRs for adoptive T cell therapy, as several engineered TCRs currently used in clinical trials share<br> similar affinity properties.