cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10532039
title: Dataset related to article "Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control"

description: This record contains raw data related to article “Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control"

Abstract



 Background:  The small-airway dysfunction (SAD), detected with impulse oscillometry (IOS) methods, has been recently better characterized in patients with asthma. However, little is known about SAD in asthmatic patients with normal spirometry (NS).

 Objective:  In this study, we aimed to investigate, in an unselected sample of 321 patients with physician-diagnosed asthma and NS, prevalence, clinical characterization, and impact on asthma control of IOS-defined SAD. As a secondary objective of the study, we focused on comparing the difference between IOS- and spirometry-defined SAD.

 Methods:  Consecutive patients with a previous diagnosis of asthma but normal spirometry at the moment of the enrollment were stratified by the presence of IOS-defined SAD (difference in resistance at 5 Hz and at 20 Hz [R5-R20] greater than 0.07 kPa x s x L-1). We have also assessed the presence of SAD defined by spirometry, according to FEF 25-75 < 65% of the predicted. Clinical and laboratory features were collected, and univariable and multivariable analyses were used to analyze cross-sectional associations between clinical variables and outcomes (SAD).

 Results:  IOS-defined SAD was present in 54.1% of the cohort. In contrast, spirometry-defined SAD was present in only 10% of patients. Subjects with IOS-defined SAD showed less well-controlled asthma and a higher mean inhaled corticosteroid dosage use compared with subjects without SAD (both P < .001). Overweight (odds ratio [OR], 1.14; 95% CI, 1.05-1.23), exacerbation history (OR, 3.06; 95% CI, 1.34-6.97), asthma-related night awakenings (OR, 6.88; 95% CI, 2.13-22.23), exercise-induced asthma symptoms (OR, 33.5; 95% CI, 9.51-117.8), and controlled asthma (OR, 0.22; 95% CI, 0.06-0.84) were independently associated with SAD.

 Conclusions:  Asthmatic patients with IOS-defined SAD showed less well-controlled asthma, more severe exacerbations and higher mean inhaled corticosteroid dosage. We confirmed exercise-induced asthma, asthma-related night awakenings, exacerbation history, and overweight as independently associated with SAD, while showing well-controlled asthma as inversely associated. SAD may be overlooked by standard spirometry.
DOI: 10.5281/zenodo.10532040
title: Dataset related to article "Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control"

description: This record contains raw data related to article “Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control"

Abstract



 Background:  The small-airway dysfunction (SAD), detected with impulse oscillometry (IOS) methods, has been recently better characterized in patients with asthma. However, little is known about SAD in asthmatic patients with normal spirometry (NS).

 Objective:  In this study, we aimed to investigate, in an unselected sample of 321 patients with physician-diagnosed asthma and NS, prevalence, clinical characterization, and impact on asthma control of IOS-defined SAD. As a secondary objective of the study, we focused on comparing the difference between IOS- and spirometry-defined SAD.

 Methods:  Consecutive patients with a previous diagnosis of asthma but normal spirometry at the moment of the enrollment were stratified by the presence of IOS-defined SAD (difference in resistance at 5 Hz and at 20 Hz [R5-R20] greater than 0.07 kPa x s x L-1). We have also assessed the presence of SAD defined by spirometry, according to FEF 25-75 < 65% of the predicted. Clinical and laboratory features were collected, and univariable and multivariable analyses were used to analyze cross-sectional associations between clinical variables and outcomes (SAD).

 Results:  IOS-defined SAD was present in 54.1% of the cohort. In contrast, spirometry-defined SAD was present in only 10% of patients. Subjects with IOS-defined SAD showed less well-controlled asthma and a higher mean inhaled corticosteroid dosage use compared with subjects without SAD (both P < .001). Overweight (odds ratio [OR], 1.14; 95% CI, 1.05-1.23), exacerbation history (OR, 3.06; 95% CI, 1.34-6.97), asthma-related night awakenings (OR, 6.88; 95% CI, 2.13-22.23), exercise-induced asthma symptoms (OR, 33.5; 95% CI, 9.51-117.8), and controlled asthma (OR, 0.22; 95% CI, 0.06-0.84) were independently associated with SAD.

 Conclusions:  Asthmatic patients with IOS-defined SAD showed less well-controlled asthma, more severe exacerbations and higher mean inhaled corticosteroid dosage. We confirmed exercise-induced asthma, asthma-related night awakenings, exacerbation history, and overweight as independently associated with SAD, while showing well-controlled asthma as inversely associated. SAD may be overlooked by standard spirometry.
DOI: 10.6084/m9.figshare.25027379
title: <b>预后、免疫浸润和</b><b>免疫治疗反应</b><b>膀胱癌</b>

description: 附表S1和S2
DOI: 10.6084/m9.figshare.25027379.v1
title: <b>预后、免疫浸润和</b><b>免疫治疗反应</b><b>膀胱癌</b>

description: 附表S1和S2
DOI: 10.57932/a3d7b9e6-9626-4d43-bb83-623900eb1053
title: Observed and mean of corrected precipitation in Ny-Alesund

description: This file contains precipitation data for Ny-Alesund from 01/01/1975 to 31/12/2022.
It contains observed data downloaded from the database of the Norwegian Meteorological Institute accessible via https://seklima.met.no/ (last accessed on 20/12/2023).
The corrected data correspond to the ensemble mean of corrected precipitation data as described in O. Champagne et al., Artificial Trends or Real Changes? Investigating Precipitation Records in Ny-Ålesund, Svalbard, submitted to the Journal of Hydrometeorology, 2023.
The file contains one table "Rain+Snow".

The columns represent the following data:
1. Date+time [UTC]: Date and time in UTC of the collection of the precipitation, i.e. the indicated values correspond to the precipitation collected in the following 12h period
2. Observed Rain: observed liquid precipitation in mm, derived from observed total precipitation as a function of temperature and solid to total precipitation ratios as described in Champagne et al. 
3. Observed Snow: observed solid precipitation in mm, derived from observed total precipitation as a function of temperature and solid to total precipitation ratios as described in Champagne et al.
4. Observed Rain+Snow: observed total precipitation in mm, downloaded from seklima.met.no
5. Ensemble mean Rain: Average of all corrected liquid precipitation in mm.
6. Ensemble mean Snow: Average of all corrected solid precipitation in mm.
7. Ensemble mean Rain+Snow: Average of all corrected total precipitation in mm.
DOI: 10.25442/hku.24906801
title: <b>Supporting data for "Highly Enantioselective cis-Dihydroxylation of Quinones,2,4-Dienoates and Styrenes Catalyzed by Iron N4 Complexes"</b>

description: My whole PhD study focuses on the iron-catalyzed asymmetric cis-dihydroxylation of alkenes. We developed a series of novel iron N4 catalysts, and they exhibited good performance in highly enantioselective cis-dihydroxylation. The dataset includes characterization of ligands and substrates.
DOI: 10.25442/hku.24906801.v1
title: <b>Supporting data for "Highly Enantioselective cis-Dihydroxylation of Quinones,2,4-Dienoates and Styrenes Catalyzed by Iron N4 Complexes"</b>

description: My whole PhD study focuses on the iron-catalyzed asymmetric cis-dihydroxylation of alkenes. We developed a series of novel iron N4 catalysts, and they exhibited good performance in highly enantioselective cis-dihydroxylation. The dataset includes characterization of ligands and substrates.
DOI: 10.25442/hku.24913236
title: Supporting data for “The pathological damage in testicular tissue of Syrian golden hamster associated with SARS-CoV-2 infection”

description: The role of SARS-CoV-2 in pathogenesis of male testicular damage remained largely unknown and our study aimed to explore more about how testes interacted with SARS-CoV-2 in hamster model. In this study, we discovered that the infection of SARS-CoV-2 BA.5 variant would cause chronic testicular degeneration changes which included the decreasing of testicular weight, size and abnormal serum sex hormone as well as degeneration and apoptosis in seminiferous tubules of Syrian golden hamsters. Furthermore, testicular tissue would not support productive SARS-CoV-2 infection. Interestingly, immune complex deposition could be found in the testes of SARS-CoV-2 infection hamsters which indicated autoimmune might play a critical role on the testicular damage.
DOI: 10.25442/hku.24913236.v1
title: Supporting data for “The pathological damage in testicular tissue of Syrian golden hamster associated with SARS-CoV-2 infection”

description: The role of SARS-CoV-2 in pathogenesis of male testicular damage remained largely unknown and our study aimed to explore more about how testes interacted with SARS-CoV-2 in hamster model. In this study, we discovered that the infection of SARS-CoV-2 BA.5 variant would cause chronic testicular degeneration changes which included the decreasing of testicular weight, size and abnormal serum sex hormone as well as degeneration and apoptosis in seminiferous tubules of Syrian golden hamsters. Furthermore, testicular tissue would not support productive SARS-CoV-2 infection. Interestingly, immune complex deposition could be found in the testes of SARS-CoV-2 infection hamsters which indicated autoimmune might play a critical role on the testicular damage.
DOI: 10.25442/hku.24916152
title: Supporting data for "<b>Antiviral effect of the branched peptide 4P9R on human rhinovirus</b>"

description: Human rhinovirus (HRV) is one of the most common viral pathogens that cause human respiratory tract infection, but there are no approved antiviral drugs for clinical use against HRV. In the recent COVID‐19 pandemic, the persistence of HRV and the complex effects of its co-infection have once again emphasised the importance of developing a broad-spectrum antiviral drug with anti-HRV effects. 4P9R is a branched broad-spectrum antiviral peptide developed by our group based on natural antiviral peptides, which has shown good antiviral potential against several influenza viruses and coronaviruses by crosslinking them and blocking their entry and release. However, the antiviral potential of 4P9R for non-enveloped viruses has not yet been tested.In this study, we demonstrated the dose-dependent antiviral effect of 4P9R against several HRV serotypes, including major group and minor group HRVs. We found that 4P9R could directly act on HRVs and crosslink the viruses on the cell surface, thus blocking their entry. We also demonstrated that 4P9R could increase viral attachment on cell surface and slightly reduce viral release. We tried to establish a mouse model for HRV replication to verify the antiviral effects of 4P9R. However, current HRV animal models could not support HRV replication with sufficient viral load changes in mice, indicating that the animal model requires further optimization. Overall, we demonstrated that this novel antiviral peptide has broad-spectrum activities against various serotypes of HRV.
DOI: 10.25442/hku.24916152.v1
title: Supporting data for "<b>Antiviral effect of the branched peptide 4P9R on human rhinovirus</b>"

description: Human rhinovirus (HRV) is one of the most common viral pathogens that cause human respiratory tract infection, but there are no approved antiviral drugs for clinical use against HRV. In the recent COVID‐19 pandemic, the persistence of HRV and the complex effects of its co-infection have once again emphasised the importance of developing a broad-spectrum antiviral drug with anti-HRV effects. 4P9R is a branched broad-spectrum antiviral peptide developed by our group based on natural antiviral peptides, which has shown good antiviral potential against several influenza viruses and coronaviruses by crosslinking them and blocking their entry and release. However, the antiviral potential of 4P9R for non-enveloped viruses has not yet been tested.In this study, we demonstrated the dose-dependent antiviral effect of 4P9R against several HRV serotypes, including major group and minor group HRVs. We found that 4P9R could directly act on HRVs and crosslink the viruses on the cell surface, thus blocking their entry. We also demonstrated that 4P9R could increase viral attachment on cell surface and slightly reduce viral release. We tried to establish a mouse model for HRV replication to verify the antiviral effects of 4P9R. However, current HRV animal models could not support HRV replication with sufficient viral load changes in mice, indicating that the animal model requires further optimization. Overall, we demonstrated that this novel antiviral peptide has broad-spectrum activities against various serotypes of HRV.
DOI: 10.25442/hku.24921258
title: <i>Supporting data for</i> "<b>Investigation into Drug Repositioning in Tackling Antimicrobial Resistance Caused </b><b>By Metallo-β-lactamases"</b>

description: The research was focused on the repurposing of drugs in tackling antimicrobial resistance caused by the production of metallo-β-lactamases in bacteria. The dataset included the data of the conducted cell-based and enzyme-based experiments, immunoblot analysis, resistance study, in vitro cell infection assay and in vivo animal study.
DOI: 10.25442/hku.24921258.v1
title: <i>Supporting data for</i> "<b>Investigation into Drug Repositioning in Tackling Antimicrobial Resistance Caused </b><b>By Metallo-β-lactamases"</b>

description: The research was focused on the repurposing of drugs in tackling antimicrobial resistance caused by the production of metallo-β-lactamases in bacteria. The dataset included the data of the conducted cell-based and enzyme-based experiments, immunoblot analysis, resistance study, in vitro cell infection assay and in vivo animal study.
DOI: 10.25442/hku.24922164.v1
title: Supporting data for “LAGUERRE PATH-DEPENDENT VOLATILITY MODEL"

description: This is the dataset that is synthesized to conduct the numerical experiment of model calibration and option pricing using the proposed LPDV model and the benchmark model in the study. The methodology for the synthesis of this dataset is outlined in the study. Asset prices can be obtained directly from the field S_t. Local volatility surfaces can be recovered from the field state according to the model parameters given in the study. Both the LPDV model and the benchmark model are then calibrated to the asset prices and the local volatilities surfaces. The calibrated models are then used to produce option prices of selected option payoffs for discussions.
DOI: 10.25442/hku.24941529
title: <b><i>Supporting data for</i></b><b> </b>"Very Brief Advice and Brief Intervention for Smoking Cessation"

description: healthcare smoking cessation trainingThis was a pre-post study, comprising 2 time points at post-training and 3-month follow-up. The study targeted all healthcare professionals and related students to join the online training. They were asked to report the (1) current practice on delivery of smoking cessation interventions at post-training and 3-month follow-up; (2) perceived capacity, confidence, and importance towards smoking cessation interventions and the satisfaction of online learning platform at 3-month follow-up.
DOI: 10.25442/hku.24941529.v1
title: <b><i>Supporting data for</i></b><b> </b>"Very Brief Advice and Brief Intervention for Smoking Cessation"

description: healthcare smoking cessation trainingThis was a pre-post study, comprising 2 time points at post-training and 3-month follow-up. The study targeted all healthcare professionals and related students to join the online training. They were asked to report the (1) current practice on delivery of smoking cessation interventions at post-training and 3-month follow-up; (2) perceived capacity, confidence, and importance towards smoking cessation interventions and the satisfaction of online learning platform at 3-month follow-up.
DOI: 10.25442/hku.24971934
title: <i>Supporting data for “Molecular Mechanism of Origin Firing in Budding Yeast”</i>

description: The primary objective of this thesis is to investigate the structures and functions of replication complexes involved in the origin firing process. To support the research conducted for this thesis, a comprehensive dataset is provided. The dataset includes information on various strains and plasmids, including different mutants. Additionally, the dataset contains the purification and assembly protocols, blotting results, and negative staining results of the proteins and complexes prepared for cryo-electron microscopy (cryo-EM) examination. Furthermore, the dataset includes the steps and blotting results of different assays conducted to elucidate the biochemical functions of the proteins. Raw data from specific analyses such as fluorescence-activated cell sorting (FACS) and spot assays are also included in the dataset.
DOI: 10.25442/hku.24971934.v1
title: <i>Supporting data for “Molecular Mechanism of Origin Firing in Budding Yeast”</i>

description: The primary objective of this thesis is to investigate the structures and functions of replication complexes involved in the origin firing process. To support the research conducted for this thesis, a comprehensive dataset is provided. The dataset includes information on various strains and plasmids, including different mutants. Additionally, the dataset contains the purification and assembly protocols, blotting results, and negative staining results of the proteins and complexes prepared for cryo-electron microscopy (cryo-EM) examination. Furthermore, the dataset includes the steps and blotting results of different assays conducted to elucidate the biochemical functions of the proteins. Raw data from specific analyses such as fluorescence-activated cell sorting (FACS) and spot assays are also included in the dataset.
DOI: 10.25919/qhm5-n609
title: Parkes observations for project P885 semester 2023OCTS_11

description: We request a continued modest monitoring cadence of once every 10 days for two radio magnetars, to track their rotation, flux density, and polarisation. 1E 1547.0-5408 has recently suffered a 'hiccup' in radiative properties as well as in its rotation, and the mid-term response to this event remains unclear. Swift J1818.0-1607 remains quite dynamic, and the unique UWL capabilities provide new opportunities to probe still mysterious radio emission mechanisms in magnetars. We will observe XTE J1810-197 and PSR J1622-4950, which ceased emission a year ago, less frequently. The overall request is 18 hours.
DOI: 10.25442/hku.24981828
title: <i>Supporting data for “Controlling the morphology of all-aqueous complex droplets”</i>

description: Emulsions formed by liquid-liquid phase separation (LLPS) are central components of pharmaceutics, foods, cosmetics and functional soft materials. Complex emulsions, such as multiple (multilayered) emulsions or Janus emulsions formed by multiple phases possess more functionalities, such as controlled release and sensing. The properties and functions of complex emulsions are intimately related to their structures. For instance, layered emulsions are designed for controlled release, while Janus emulsions are optimal templates for targeted release. Thus, controlling the morphology of complex emulsions is very critical. Traditionally, the morphology of complex emulsion can be tuned by surfactants, as seen in oil-water systems, where dynamically reconfigurable complex emulsions have been realized by gradually varying the concentration of surfactants or designing stimuli-responsive surfactants. However, such surfactant-based approach is normally not effective in all-aqueous systems. This is because the all-aqueous droplets possess ultra-low interfacial tension (from 1 µN/m to 1 mN/m), which hinders the adsorption of general surfactant-like molecules at their interfaces. Depending on the interaction between molecules, all-aqueous complex droplets can be generated from both segregative and associative LLPS. A unique feature of all-aqueous complex droplets is their biocompatibility with biological components that is unattainable by traditional oil-water systems, making them ideal vehicles for macromolecules. Composition and temperature-dependent routes have been reported to shape certain all-aqueous multiphase droplets. For instance, the number of layer within an all-aqueous layered droplet can be altered by relative ratio of two segregative polymers. Nevertheless, a general strategy to achieve dynamic all-aqueous complex emulsions with different wetting configurations has yet to be realized.In our work, we develop methods to controllably form all-aqueous complex emulsions under the ultra-low interfacial tension regime. To gain a comprehensive understanding and develop generic strategies for morphology control, all-aqueous complex droplets from different LLPS mechanisms, namely segregative and associative LLPS, are studied.
DOI: 10.25442/hku.24981828.v1
title: <i>Supporting data for “Controlling the morphology of all-aqueous complex droplets”</i>

description: Emulsions formed by liquid-liquid phase separation (LLPS) are central components of pharmaceutics, foods, cosmetics and functional soft materials. Complex emulsions, such as multiple (multilayered) emulsions or Janus emulsions formed by multiple phases possess more functionalities, such as controlled release and sensing. The properties and functions of complex emulsions are intimately related to their structures. For instance, layered emulsions are designed for controlled release, while Janus emulsions are optimal templates for targeted release. Thus, controlling the morphology of complex emulsions is very critical. Traditionally, the morphology of complex emulsion can be tuned by surfactants, as seen in oil-water systems, where dynamically reconfigurable complex emulsions have been realized by gradually varying the concentration of surfactants or designing stimuli-responsive surfactants. However, such surfactant-based approach is normally not effective in all-aqueous systems. This is because the all-aqueous droplets possess ultra-low interfacial tension (from 1 µN/m to 1 mN/m), which hinders the adsorption of general surfactant-like molecules at their interfaces. Depending on the interaction between molecules, all-aqueous complex droplets can be generated from both segregative and associative LLPS. A unique feature of all-aqueous complex droplets is their biocompatibility with biological components that is unattainable by traditional oil-water systems, making them ideal vehicles for macromolecules. Composition and temperature-dependent routes have been reported to shape certain all-aqueous multiphase droplets. For instance, the number of layer within an all-aqueous layered droplet can be altered by relative ratio of two segregative polymers. Nevertheless, a general strategy to achieve dynamic all-aqueous complex emulsions with different wetting configurations has yet to be realized.In our work, we develop methods to controllably form all-aqueous complex emulsions under the ultra-low interfacial tension regime. To gain a comprehensive understanding and develop generic strategies for morphology control, all-aqueous complex droplets from different LLPS mechanisms, namely segregative and associative LLPS, are studied.