cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4063931
title: From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2

description: <strong>Aims</strong>: Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two LQT2 patients, we tested whether the commercial association Lumacaftor+Ivacaftor (LUM+IVA) could shorten the QTc in the same two patients. <strong>Methods and Results</strong>: After hospital admission and one day of baseline recordings, half dose LUM+IVA was administered on day 1, followed by full dose (LUM 800 mg + IVA 500 mg) for 7 days. A continuous 12-lead Holter ECG allowed a large number of blind QTc measurements. LUM+IVA shortened QTc significantly in both patients: in V6 from 551±22 to 523±35 ms in Patient1, and from 472±21 to 449±20 ms in Patient2; in DII from 562±25 to 549±35 ms in Patient1, and from 485±32 to 452±18 ms in Patient2. In both patients the percentage of QTc values in the lower tertile increased strikingly: in V6 from 33% to 68% and from 33% to 76%; in DII from 33% to 50% and from 33% to 87%. In the wash-out period a rebound in QTc was observed. Patient1 more than Patient2 developed diarrhoea during the study. <strong>Conclusion</strong>: This represents the first attempt to validate in patients the <em>in vitro</em> results of a drug repurposing strategy for cardiovascular disorders. LUM+IVA shortened significantly the QTc in the two LQT2 patients with a trafficking defect, largely confirming the findings in their iPSC-CMs but with smaller quantitative changes. The findings are encouraging but immediate translation into clinical practice, without validation in more patients, would be premature.
DOI: 10.18462/iir.iccc.2020.296272
title: Proposal of a method to determine the effects of doors opening to size equipment of delivery trucks.
DOI: 10.5281/zenodo.4063940
title: Dataset for "Guidelines to study and develop soft electrode systems for neural stimulation"

description: Dataset for "Guidelines to study and develop soft electrode systems for neural stimulation"
DOI: 10.5281/zenodo.4063939
title: Dataset for "Guidelines to study and develop soft electrode systems for neural stimulation"

description: Dataset for "Guidelines to study and develop soft electrode systems for neural stimulation"
DOI: 10.18462/iir.iccc.2020.292592
title: Innovative method for evaluating liquid nitrogen consumption of cryogenic transport refrigerated units.
DOI: 10.25345/c5pf6g
title: MassIVE MSV000086227 - SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs
title: Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen D, Bauer MR, Taylor HB, Conway HL, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Keskin DB, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. 2020. T cell-mediated immunity may play a critical role in controlling and establishing protective immunity against SARS-CoV-2 infection; yet the repertoire of viral epitopes responsible for T cell response activation remains mostly unknown. Identification of viral peptides presented on class I human leukocyte antigen (HLA-I) can reveal epitopes for recognition by cytotoxic T cells and potential incorporation into vaccines. Here, we report the first HLA-I immunopeptidome of SARS-CoV-2 in two human cell lines at different times post-infection using mass spectrometry. We found HLA-I peptides derived not only from canonical ORFs, but also from internal out-of-frame ORFs in Spike and Nucleoprotein not captured by current vaccines. Proteomics analyses of infected cells revealed that SARS-CoV-2 may interfere with antigen processing and immune signaling pathways. Based on the endogenously processed and presented viral peptides that we identified, we estimate that a pool of 24 peptides would provide one or more peptides for presentation by at least one HLA allele in 99% of the human population. These biological insights and the list of naturally presented SARS-CoV-2 peptides will facilitate data-driven selection of peptides for immune monitoring and vaccine development.
DOI: 10.5281/zenodo.4063950
title: Data set from Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R. Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals. Front Physiol. 2019 Aug 23;10:1061. doi: 10.3389/fphys.2019.01061. PMID: 31507438; PMCID: PMC6716544.

description: Data set from Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R. Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals. Front Physiol. 2019 Aug 23;10:1061. doi: 10.3389/fphys.2019.01061. PMID: 31507438; PMCID: PMC6716544. This is the abstract: Orthostatic intolerance commonly occurs after prolonged bed rest, thus increasing the risk of syncope and falls. Baroreflex-mediated adjustments of heart rate and sympathetic vasomotor activity (muscle sympathetic nerve activity - MSNA) are crucial for orthostatic tolerance. We hypothesized that prolonged bed rest deconditioning alters overall baroreceptor functioning, thereby reducing orthostatic tolerance in healthy volunteers. As part of the European Space Agency Medium-term Bed Rest protocol, 10 volunteers were studied before and after 21 days of -6° head down bed rest (HDBR). In both conditions, subjects underwent ECG, beat-by-beat blood pressure, respiratory activity, and MSNA recordings while supine (REST) and during a 15-min 80° head-up tilt (TILT) followed by a 3-min -10 mmHg stepwise increase of lower body negative pressure to pre-syncope. Cardiac baroreflex sensitivity (cBRS) was obtained in the time (sequence method) and frequency domain (spectrum and cross-spectrum analyses of RR interval and systolic arterial pressure - SAP, variability). Baroreceptor modulation of sympathetic discharge activity to the vessels (sBRS) was estimated by the slope of the regression line between the percentage of MSNA burst occurrence and diastolic arterial pressure. Orthostatic tolerance significantly decreased after HDBR (12 ± 0.6 min) compared to before (21 ± 0.6 min). While supine, heart rate, SAP, and cBRS were unchanged before and after HDBR, sBRS gain was slightly depressed after than before HDBR (sBRS: -6.0 ± 1.1 versus -2.9 ± 1.5 burst% × mmHg<sup>-1</sup>, respectively). During TILT, HR was higher after than before HDBR (116 ± 4 b/min versus 100 ± 4 b/min, respectively), SAP was unmodified in both conditions, and cBRS indexes were lower after HDBR (<em>α</em> index: 3.4 ± 0.7 ms/mmHg; BRS<sub>SEQ</sub> 4.0 ± 1.0) than before (<em>α</em> index: 6.4 ± 1.0 ms/mmHg; BRS<sub>SEQ</sub> 6.8 ± 1.2). sBRS gain was significantly more depressed after HDBR than before (sBRS: -2.3 ± 0.7 versus -4.4 ± 0.4 burst% × mmHg<sup>-1</sup>, respectively). Our findings suggest that baroreflex-mediated adjustments in heart rate and MSNA are impaired after prolonged bed rest. The mechanism likely contributes to the decrease in orthostatic tolerance.
DOI: 10.5281/zenodo.4063949
title: Data set from Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R. Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals. Front Physiol. 2019 Aug 23;10:1061. doi: 10.3389/fphys.2019.01061. PMID: 31507438; PMCID: PMC6716544.

description: Data set from Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R. Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals. Front Physiol. 2019 Aug 23;10:1061. doi: 10.3389/fphys.2019.01061. PMID: 31507438; PMCID: PMC6716544. This is the abstract: Orthostatic intolerance commonly occurs after prolonged bed rest, thus increasing the risk of syncope and falls. Baroreflex-mediated adjustments of heart rate and sympathetic vasomotor activity (muscle sympathetic nerve activity - MSNA) are crucial for orthostatic tolerance. We hypothesized that prolonged bed rest deconditioning alters overall baroreceptor functioning, thereby reducing orthostatic tolerance in healthy volunteers. As part of the European Space Agency Medium-term Bed Rest protocol, 10 volunteers were studied before and after 21 days of -6° head down bed rest (HDBR). In both conditions, subjects underwent ECG, beat-by-beat blood pressure, respiratory activity, and MSNA recordings while supine (REST) and during a 15-min 80° head-up tilt (TILT) followed by a 3-min -10 mmHg stepwise increase of lower body negative pressure to pre-syncope. Cardiac baroreflex sensitivity (cBRS) was obtained in the time (sequence method) and frequency domain (spectrum and cross-spectrum analyses of RR interval and systolic arterial pressure - SAP, variability). Baroreceptor modulation of sympathetic discharge activity to the vessels (sBRS) was estimated by the slope of the regression line between the percentage of MSNA burst occurrence and diastolic arterial pressure. Orthostatic tolerance significantly decreased after HDBR (12 ± 0.6 min) compared to before (21 ± 0.6 min). While supine, heart rate, SAP, and cBRS were unchanged before and after HDBR, sBRS gain was slightly depressed after than before HDBR (sBRS: -6.0 ± 1.1 versus -2.9 ± 1.5 burst% × mmHg<sup>-1</sup>, respectively). During TILT, HR was higher after than before HDBR (116 ± 4 b/min versus 100 ± 4 b/min, respectively), SAP was unmodified in both conditions, and cBRS indexes were lower after HDBR (<em>α</em> index: 3.4 ± 0.7 ms/mmHg; BRS<sub>SEQ</sub> 4.0 ± 1.0) than before (<em>α</em> index: 6.4 ± 1.0 ms/mmHg; BRS<sub>SEQ</sub> 6.8 ± 1.2). sBRS gain was significantly more depressed after HDBR than before (sBRS: -2.3 ± 0.7 versus -4.4 ± 0.4 burst% × mmHg<sup>-1</sup>, respectively). Our findings suggest that baroreflex-mediated adjustments in heart rate and MSNA are impaired after prolonged bed rest. The mechanism likely contributes to the decrease in orthostatic tolerance.
DOI: 10.5517/ccdc.csd.ccpv4wj
title: CCDC 650748: Experimental Crystal Structure Determination

description: Related Article: Shampa Chakraborty, Shyamaprosad Goswami, Annada C. Maity, Ching Kheng Quah, Sandipan Halder|2020|J.Chem.Cryst.|50|164|doi:10.1007/s10870-019-00805-5
DOI: 10.5517/ccdc.csd.cc10815h
title: CCDC 931245: Experimental Crystal Structure Determination

description: Related Article: Shampa Chakraborty, Shyamaprosad Goswami, Annada C. Maity, Ching Kheng Quah, Sandipan Halder|2020|J.Chem.Cryst.|50|164|doi:10.1007/s10870-019-00805-5
DOI: 10.5517/ccdc.csd.cc10814g
title: CCDC 931244: Experimental Crystal Structure Determination

description: Related Article: Shampa Chakraborty, Shyamaprosad Goswami, Annada C. Maity, Ching Kheng Quah, Sandipan Halder|2020|J.Chem.Cryst.|50|164|doi:10.1007/s10870-019-00805-5
DOI: 10.5517/ccdc.csd.cc141kxn
title: CCDC 1044201: Experimental Crystal Structure Determination

description: Related Article: Xinchen Chi, Lanqing Wang, Shouwen Jin, Daqi Wang, Ying Zhao, Zhaohui Tao|2019|J.Chem.Cryst.|49|155|doi:10.1007/s10870-018-0753-z
DOI: 10.5517/ccdc.csd.cc142jd4
title: CCDC 1045115: Experimental Crystal Structure Determination

description: Related Article: Xinchen Chi, Lanqing Wang, Shouwen Jin, Daqi Wang, Ying Zhao, Zhaohui Tao|2019|J.Chem.Cryst.|49|155|doi:10.1007/s10870-018-0753-z
DOI: 10.5517/ccdc.csd.cc1k1ybw
title: CCDC 1431838: Experimental Crystal Structure Determination

description: Related Article: Liping Zhou, Rongkai Du, Xianrui Zhang, Hua Chen, Su Guan, Jing Li, Lei Zhang|2019|J.Chem.Cryst.|49|37|doi:10.1007/s10870-018-0754-y
DOI: 10.5517/ccdc.csd.cc1k1ycx
title: CCDC 1431839: Experimental Crystal Structure Determination

description: Related Article: Liping Zhou, Rongkai Du, Xianrui Zhang, Hua Chen, Su Guan, Jing Li, Lei Zhang|2019|J.Chem.Cryst.|49|37|doi:10.1007/s10870-018-0754-y
DOI: 10.5517/ccdc.csd.cc1mkc2m
title: CCDC 1506230: Experimental Crystal Structure Determination

description: Related Article: Andrii Vakulka, Evgeny Goreshnik|2018|J.Coord.Chem.|71|2426|doi:10.1080/00958972.2018.1481210
DOI: 10.5517/ccdc.csd.cc1mpjrl
title: CCDC 1510250: Experimental Crystal Structure Determination

description: Related Article: Piotr Kuś, Joachim Kusz, Maria Książek|2020|J.Chem.Cryst.|50|21|doi:10.1007/s10870-018-0752-0
DOI: 10.5517/ccdc.csd.cc1nphnh
title: CCDC 1540007: Experimental Crystal Structure Determination

description: Related Article: Shan Zhu, Huiping Hu, Jiugang Hu, Jiyuan Li, Fang Hu, YongxI Wang|2018|J.Coord.Chem.|71|2441|doi:10.1080/00958972.2018.1482416
DOI: 10.5517/ccdc.csd.ccytbqs
title: CCDC 888296: Experimental Crystal Structure Determination

description: Related Article: Jean Guillon, Stéphane Moreau, Vanessa Desplat, Marian Vincenzi, Noël Pinaud, Solène Savrimoutou, Sandra Rubio, Luisa Ronga, Filomena Rossi, Mathieu Marchivie|2019|J.Chem.Cryst.|49|106|doi:10.1007/s10870-018-0734-2
DOI: 10.5517/ccdc.csd.cc1p2mw8
title: CCDC 1551670: Experimental Crystal Structure Determination

description: Related Article: Yogesh B. Wagh,  Swapnil A. Padvi,  Pramod P. Mahulikar,  Dipak S. Dalal|2020|J.Heterocycl.Chem.|57|1101|doi:10.1002/jhet.3846
DOI: 10.5517/ccdc.csd.cc1p4g1b
title: CCDC 1553411: Experimental Crystal Structure Determination

description: Related Article: Philipp Langer, Lixu Yang, Constance R. Pfeiffer, William Lewis, Neil R. Champness|2019|Dalton Trans.|48|58|doi:10.1039/C8DT04096F
DOI: 10.5281/zenodo.4063964
title: Data set from Martins de Abreu R, Porta A, Rehder-Santos P, Cairo B, Donisete da Silva C, De Favari Signini É, Sakaguchi CA, Catai AM. Effects of inspiratory muscle-training intensity on cardiovascular control in amateur cyclists. Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R891-R902. doi: 10.1152/ajpregu.00167.2019. Epub 2019 Oct 9. PMID: 31596110.

description: Data set from Martins de Abreu R, Porta A, Rehder-Santos P, Cairo B, Donisete da Silva C, De Favari Signini É, Sakaguchi CA, Catai AM. Effects of inspiratory muscle-training intensity on cardiovascular control in amateur cyclists. Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R891-R902. doi: 10.1152/ajpregu.00167.2019. Epub 2019 Oct 9. PMID: 31596110. This is the abstract: Chronic effects of inspiratory muscle training (IMT) on autonomic function and baroreflex regulation are poorly studied. This study aims at evaluating chronic effects of different IMT intensities on cardiovascular control in amateur cyclists. A longitudinal, randomized, controlled blind study was performed on 30 recreational male cyclists undergoing IMT for 11 wk. Participants were randomly allocated into sham-trained group (SHAM, <em>n</em> = 9), trained group at 60% of the maximal inspiratory pressure (MIP60, <em>n</em> = 10), and trained group at critical inspiratory pressure (CIP, <em>n</em> = 11). Electrocardiogram, finger arterial pressure, and respiratory movements were recorded before (PRE) and after (POST) training at rest in supine position (REST) and during active standing (STAND). From the beat-to-beat series of heart period (HP) and systolic arterial pressure (SAP), we computed time domain markers, frequency domain indexes in the low frequency (0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) bands, an entropy-based complexity index (CI), and baroreflex markers estimated from spontaneous HP-SAP sequences. Compared with SHAM, the positive effect of MIP60 over the HP series led to the HF power increase during REST (PRE: 521.2 ± 447.5 ms<sup>2</sup>; POST: 1,161 ± 878.9 ms<sup>2</sup>) and the CI rise during STAND (PRE: 0.82 ± 0.18; POST: 0.97 ± 0.13). Conversely, the negative effect of CIP took the form of the decreased HP mean during STAND (PRE: 791 ± 71 ms; POST: 737 ± 95 ms). No effect of IMT was visible over SAP and baroreflex markers. These findings suggest that moderate-intensity IMT might be beneficial when the goal is to limit cardiac sympathetic hyperactivity at REST and/or in response to STAND. <strong> </strong>
DOI: 10.5281/zenodo.4063963
title: Data set from Martins de Abreu R, Porta A, Rehder-Santos P, Cairo B, Donisete da Silva C, De Favari Signini É, Sakaguchi CA, Catai AM. Effects of inspiratory muscle-training intensity on cardiovascular control in amateur cyclists. Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R891-R902. doi: 10.1152/ajpregu.00167.2019. Epub 2019 Oct 9. PMID: 31596110.

description: Data set from Martins de Abreu R, Porta A, Rehder-Santos P, Cairo B, Donisete da Silva C, De Favari Signini É, Sakaguchi CA, Catai AM. Effects of inspiratory muscle-training intensity on cardiovascular control in amateur cyclists. Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R891-R902. doi: 10.1152/ajpregu.00167.2019. Epub 2019 Oct 9. PMID: 31596110. This is the abstract: Chronic effects of inspiratory muscle training (IMT) on autonomic function and baroreflex regulation are poorly studied. This study aims at evaluating chronic effects of different IMT intensities on cardiovascular control in amateur cyclists. A longitudinal, randomized, controlled blind study was performed on 30 recreational male cyclists undergoing IMT for 11 wk. Participants were randomly allocated into sham-trained group (SHAM, <em>n</em> = 9), trained group at 60% of the maximal inspiratory pressure (MIP60, <em>n</em> = 10), and trained group at critical inspiratory pressure (CIP, <em>n</em> = 11). Electrocardiogram, finger arterial pressure, and respiratory movements were recorded before (PRE) and after (POST) training at rest in supine position (REST) and during active standing (STAND). From the beat-to-beat series of heart period (HP) and systolic arterial pressure (SAP), we computed time domain markers, frequency domain indexes in the low frequency (0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) bands, an entropy-based complexity index (CI), and baroreflex markers estimated from spontaneous HP-SAP sequences. Compared with SHAM, the positive effect of MIP60 over the HP series led to the HF power increase during REST (PRE: 521.2 ± 447.5 ms<sup>2</sup>; POST: 1,161 ± 878.9 ms<sup>2</sup>) and the CI rise during STAND (PRE: 0.82 ± 0.18; POST: 0.97 ± 0.13). Conversely, the negative effect of CIP took the form of the decreased HP mean during STAND (PRE: 791 ± 71 ms; POST: 737 ± 95 ms). No effect of IMT was visible over SAP and baroreflex markers. These findings suggest that moderate-intensity IMT might be beneficial when the goal is to limit cardiac sympathetic hyperactivity at REST and/or in response to STAND. <strong> </strong>
DOI: 10.5281/zenodo.4059529
title: Primary data of PhD thesis submitted by Catharina Lange

description: Primary data of cumulative PhD thesis submitted by Catharina Lange.
DOI: 10.5281/zenodo.4059528
title: Primary data of PhD thesis submitted by Catharina Lange

description: Primary data of cumulative PhD thesis submitted by Catharina Lange.
DOI: 10.18462/iir.iccc.2020.292566
title: Conceptual study of a transportable cooling system based on renewable energy for use on fruits and vegetables.
DOI: 10.5281/zenodo.4063942
title: BenjaminSMoss/Sheets-main-data-csv: Photocatalyst Sheets Data NM19124170A

description: Essential data in CSV format from our publication in Nature Materials (2020) entitled Linking in-situ charge accumulation to electronic structure in doped SrTiO3 reveals design principles for hydrogen evolving photocatalysts. by Benjamin Moss, Qian Wang, Keith T. Butler, Ricardo Grau-Crespo, Shababa Selim, Anna Regoutz , Takashi Hisatomi , Robert Godin, David J. Payne, Andreas Kafizas, Kazunari Domen, Ludmilla Steier* and James R. Durrant repository contains XPS data (shows raw EB folowed by EB after C 1s calibration to 284.8 eV. O 1s is provided with the VB data to faciliate core line separation analysis) DFT data (STO, Rh:STO and La,Rh:STO all have differnt VB minima due to the introduction of new states. Thus all have different 0K Ef positions DFT data was calibrated to the CB edge, the potential of which we calcualte to be unaffected by doping.) SEC data (was repeated twice with samples from two batches to make sure the effects observed was reproducable. For simplicity, only one set of SEC data is provided here. To get the sigmoidal plots shown normalise against 0 or -0.2 V RHE (i.e. divide everything else by the negative abs value at 590 nm at this potential)) TAS and PIA data.
DOI: 10.5281/zenodo.4063941
title: BenjaminSMoss/Sheets-main-data-csv: Photocatalyst Sheets Data NM19124170A

description: Essential data in CSV format from our publication in Nature Materials (2020) entitled Linking in-situ charge accumulation to electronic structure in doped SrTiO3 reveals design principles for hydrogen evolving photocatalysts. by Benjamin Moss, Qian Wang, Keith T. Butler, Ricardo Grau-Crespo, Shababa Selim, Anna Regoutz , Takashi Hisatomi , Robert Godin, David J. Payne, Andreas Kafizas, Kazunari Domen, Ludmilla Steier* and James R. Durrant repository contains XPS data (shows raw EB folowed by EB after C 1s calibration to 284.8 eV. O 1s is provided with the VB data to faciliate core line separation analysis) DFT data (STO, Rh:STO and La,Rh:STO all have differnt VB minima due to the introduction of new states. Thus all have different 0K Ef positions DFT data was calibrated to the CB edge, the potential of which we calcualte to be unaffected by doping.) SEC data (was repeated twice with samples from two batches to make sure the effects observed was reproducable. For simplicity, only one set of SEC data is provided here. To get the sigmoidal plots shown normalise against 0 or -0.2 V RHE (i.e. divide everything else by the negative abs value at 590 nm at this potential)) TAS and PIA data.