cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/133130
title: Winch data collected during research cruise SR1812 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203563.v1
title: MOESM1 of An improved secretion signal enhances the secretion of model proteins from Pichia pastoris

description: Additional file 1: Figure S1. The S. cerevisiae α-factor secretion signal. Depicted is the 5′ portion of the MFα1 gene encoding pre-pro-α-factor. This sequence encodes the Leu42 variant. Cleavage sites for signal peptidase and Kex2 are marked, and Leu42 and Asp83 are highlighted. This image was generated using SnapGene software. Figure S2. Low variation in secreted protein levels between clones. Each of the indicated constructs was transformed into P. pastoris cells, and six independent clones with confirmed single integrations were cultured and then analyzed as in Fig. 2a to measure extracellular protein. For each construct, the average protein level for the six clones was defined as 1.0. Two representative clones of a given construct were chosen for further analysis. The red boxes represent E2-Crimson constructs, and the black boxes represent BTL2 constructs. Figure S3. Immunoblot showing cell-associated and secreted E2-Crimson. Strains that expressed E2-Crimson fused to the indicated secretion signals were grown and induced. Fractions containing cell-associated E2-Crimson (“C”) or E2-Crimson in the extracellular medium (“M”) were subjected to SDS-PAGE and immunoblotting. The molecular weight (“MW”) marker was the Precision Plus Protein Dual Color Standards (Bio-Rad). Molecular weights of the protein standards are indicated. Figure S4. Large image fields of cells expressing the various constructs. From the experiment of Fig. 3, large image fields were captured to illustrate that the fluorescence patterns were consistent among the cells in a population, and that cells expressing constructs with the α-factor signal sequence were often unusually large. Scale bar, 2 μm. Figure S5. Distribution of ER-targeted GFP-HDEL before induced expression of E2-Crimson constructs. The same cultures shown in Fig. 4b were examined by fluorescence microscopy before methanol-induced expression of the E2-Crimson constructs. All of the strains showed a typical ER pattern for GFP-HDEL. Scale bar, 2 μm. Figure S6. Theoretical prediction of aggregation propensities in the two allelic variants of the α-factor pro region. Left, the Leu42 variant of the α-factor pro region was analyzed using the online AGGRESCAN tool ( http://bioinf.uab.es/aap/ ). The position of Leu42 in a predicted aggregation-prone region is marked. Right, the same analysis was performed for the Ser42 variant of the α-factor pro region.
DOI: 10.7284/133131
title: Winch data collected during research cruise SR1812 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/131989
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SR1813 using a Hawaii UHDAS instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203548
title: Additional file 4 of Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

description: Annotation Overview. Excel sheet containing all human annotation sub sets which were used to generate features for model training. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.7203548.v1
title: Additional file 4 of Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

description: Annotation Overview. Excel sheet containing all human annotation sub sets which were used to generate features for model training. (XLSX 15 kb)
DOI: 10.7284/131986
title: GNSS (Global Navigation Satellite System) data collected during research cruise SR1813 using a Trimble BD982 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203542
title: Additional file 3 of Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

description: Annotation Overview. Excel sheet containing all mouse annotation sub sets which were used to generate features for model training. (XLSX 15 kb)
DOI: 10.7284/133165
title: Gravimeter data collected during research cruise SR1813 using a Bell BGM-3 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203539
title: Additional file 2 of Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

description: Annotation Overview. Excel sheet containing all human and mouse annotations which were used to generate features for model training. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.7203539.v1
title: Additional file 2 of Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

description: Annotation Overview. Excel sheet containing all human and mouse annotations which were used to generate features for model training. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.7203542.v1
title: Additional file 3 of Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

description: Annotation Overview. Excel sheet containing all mouse annotation sub sets which were used to generate features for model training. (XLSX 15 kb)
DOI: 10.7284/131990
title: INS (Inertial Navigation System) data collected during research cruise SR1813 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203416
title: Graph Design

description: Using the User Manual included in the research paper, and the Graph Design Example file as a reference, the user enters or saves all the vertices and edges needed to specify the model of the system topography.
DOI: 10.6084/m9.figshare.7203533
title: Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen

description: <i>Background:</i> The Edinburgh cognitive and behavioral ALS screen (ECAS) was developed specifically to detect cognitive and behavioral changes in patients with amyotrophic lateral sclerosis (ALS). Differences with regard to normative data of different (language) versions of neuropsychological tests such as the ECAS exist. <i>Objective:</i> To derive norms for the Dutch version of the ECAS. <i>Methods:</i> Normative data were derived from a large sample of 690 control subjects and cognitive profiles were compared between a matched sample of 428 patients with ALS and 428 control subjects. <i>Results:</i> Age, level of education, and sex were significantly associated with performance on the ECAS in the normative sample. ECAS data were not normally distributed and therefore normative data were expressed as percentile ranks. The comparison of ECAS scores between patients and control subjects demonstrated that patients obtained significantly lower scores for language, executive function, verbal fluency, and memory, which is in line with the established cognitive profile of ALS. <i>Conclusion:</i> For an accurate interpretation of ECAS results, it is important to derive normative data in large samples with nonparametric methods. The present normative data provide healthcare professionals with an accurate estimate of how common or uncommon patients’ ECAS scores are and provide a useful supplement to existing cut-off scores.
DOI: 10.7284/131997
title: INS (Inertial Navigation System) data collected during research cruise SR1813 using a iXSea Hydrins instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203533.v1
title: Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen

description: <i>Background:</i> The Edinburgh cognitive and behavioral ALS screen (ECAS) was developed specifically to detect cognitive and behavioral changes in patients with amyotrophic lateral sclerosis (ALS). Differences with regard to normative data of different (language) versions of neuropsychological tests such as the ECAS exist. <i>Objective:</i> To derive norms for the Dutch version of the ECAS. <i>Methods:</i> Normative data were derived from a large sample of 690 control subjects and cognitive profiles were compared between a matched sample of 428 patients with ALS and 428 control subjects. <i>Results:</i> Age, level of education, and sex were significantly associated with performance on the ECAS in the normative sample. ECAS data were not normally distributed and therefore normative data were expressed as percentile ranks. The comparison of ECAS scores between patients and control subjects demonstrated that patients obtained significantly lower scores for language, executive function, verbal fluency, and memory, which is in line with the established cognitive profile of ALS. <i>Conclusion:</i> For an accurate interpretation of ECAS results, it is important to derive normative data in large samples with nonparametric methods. The present normative data provide healthcare professionals with an accurate estimate of how common or uncommon patients’ ECAS scores are and provide a useful supplement to existing cut-off scores.
DOI: 10.6084/m9.figshare.7203533.v2
title: Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen

description: <i>Background:</i> The Edinburgh cognitive and behavioral ALS screen (ECAS) was developed specifically to detect cognitive and behavioral changes in patients with amyotrophic lateral sclerosis (ALS). Differences with regard to normative data of different (language) versions of neuropsychological tests such as the ECAS exist. <i>Objective:</i> To derive norms for the Dutch version of the ECAS. <i>Methods:</i> Normative data were derived from a large sample of 690 control subjects and cognitive profiles were compared between a matched sample of 428 patients with ALS and 428 control subjects. <i>Results:</i> Age, level of education, and sex were significantly associated with performance on the ECAS in the normative sample. ECAS data were not normally distributed and therefore normative data were expressed as percentile ranks. The comparison of ECAS scores between patients and control subjects demonstrated that patients obtained significantly lower scores for language, executive function, verbal fluency, and memory, which is in line with the established cognitive profile of ALS. <i>Conclusion:</i> For an accurate interpretation of ECAS results, it is important to derive normative data in large samples with nonparametric methods. The present normative data provide healthcare professionals with an accurate estimate of how common or uncommon patients’ ECAS scores are and provide a useful supplement to existing cut-off scores.
DOI: 10.6084/m9.figshare.7203410
title: Graph Example

description: This Excel table contains a detailed example of a graph-theoretic model used in the specification of the physical topology and network of the modeled system.
DOI: 10.6084/m9.figshare.7203404
title: Graph Input Data Example

description: This Excel file provides a detailed example of the computation data needed to compute risk, Safety, Security and other system properties.
DOI: 10.6084/m9.figshare.7203410.v1
title: Graph Example

description: This Excel table contains a detailed example of a graph-theoretic model used in the specification of the physical topology and network of the modeled system.
DOI: 10.7284/131998
title: INS (Inertial Navigation System) data collected during research cruise SR1813 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203401
title: Graph Input Data

description: With the user manual provided at the end of the research manuscript, and the Graph Input Data Example.xlsx as a reference, the user provides all the graph semantic data required to evaluate all the performance criteria for the system.These criteria include the probability that the principal target can be reached, and the costs, elapsed times and total vulnerability resulting from a penetration attempt by one or more intruders.This performance computation is accurate and efficient, requiring an insignificant amount of computation time.It also resolves all the statistical dependencies and probabilistic uncertainties believed to be an important challenge to a risk manager and his or her analysts.<br><br><br>User enters the Graph Topological data in this excel file, thereby creating a topological model.
DOI: 10.6084/m9.figshare.7203401.v1
title: Graph Input Data

description: With the user manual provided at the end of the research manuscript, and the Graph Input Data Example.xlsx as a reference, the user provides all the graph semantic data required to evaluate all the performance criteria for the system.These criteria include the probability that the principal target can be reached, and the costs, elapsed times and total vulnerability resulting from a penetration attempt by one or more intruders.This performance computation is accurate and efficient, requiring an insignificant amount of computation time.It also resolves all the statistical dependencies and probabilistic uncertainties believed to be an important challenge to a risk manager and his or her analysts.<br><br><br>User enters the Graph Topological data in this excel file, thereby creating a topological model.
DOI: 10.6084/m9.figshare.7203398
title: A General Method for Quantifying Risk using Probabilistic Graph Models

description: This research manuscript presents a novel method for computing the risk, safety and reliability associated with the functioning and operation of complex systems. Together with its data support files, it provides a complete framework for resolving statistical dependencies and probabilistic uncertainties.
DOI: 10.7284/131999
title: INS (Inertial Navigation System) data collected during research cruise SR1813 using a iXSea Hydrins instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/131982
title: Meteorological Station data collected during research cruise SR1813 using a SIO MET-System instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/131987
title: Multibeam Echosounder data collected during research cruise SR1813 using a Kongsberg EM712 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/131988
title: Multibeam Echosounder data collected during research cruise SR1813 using a Kongsberg EM122 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203305
title: Classifier and vectorizer pickle files

description: Classifiers and vectorizers for ATHENA CogPO label prediction.
DOI: 10.7284/131991
title: Multibeam Echosounder data collected during research cruise SR1813 using a Kongsberg EM712 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203299
title: multiclass output labels

description: output labels for the multiclass clasifier ground coverage in the rural images.<br>
DOI: 10.6084/m9.figshare.7203299.v1
title: multiclass output labels

description: output labels for the multiclass clasifier ground coverage in the rural images.<br>
DOI: 10.7284/131984
title: Singlebeam Echosounder data collected during research cruise SR1813 using a Knudsen 3260 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/131994
title: Winch data collected during research cruise SR1813 using a Markey DETW-9-11 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203245
title: Tree

description: newick file necessary to replicate Fig. S1 in https://github.com/KyleTDavid/NGS/blob/master/get_plots.R. Tree topology taken from NCBI taxonomy database.
DOI: 10.7284/131995
title: Winch data collected during research cruise SR1813 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203140
title: Data table for historical cardiovascular health in Surinamese men

description: This dataset consists of a single data table in <b>.docx</b> Word document format, holding aggregated data on cardiovascular risk factors for men in Paramaribo, Suriname.<br>In related studies from 2013-2015, the population of Suriname was found to have a high cardiovascular risk factor burden. Around 40% of the general population was hypertensive, 15% had diabetes, and the large majority had one or more risk factors for cardiovascular disease. However, it was not possible to assess time trends in these risk factors as historical data were lacking. <br> This dataset holds rediscovered and hitherto unpublished aggregated data of what was apparently the first population study on measured blood pressure, diabetes, and cardiovascular health in men in Suriname, assessed in 1973. These are presented alongside 2013 data for the same variables. These data may help understand the cardiovascular risk factor escalation of the local population in time as well as aid in projections of future cardiovascular disease in this middle income country. <br>The variables reported in the data table are: sample size (%), sampling method, African ancestry (%), Regular leisure exercise (%), Ever smoked tobacco (%), Hypertension (%) and Diabetes (%).
DOI: 10.6084/m9.figshare.7203245.v2
title: Tree

description: newick file necessary to replicate Fig. S1 in https://github.com/KyleTDavid/NGS/blob/master/get_plots.R. Tree topology taken from NCBI taxonomy database.
DOI: 10.6084/m9.figshare.7203140.v1
title: Data table for historical cardiovascular health in Surinamese men

description: This dataset consists of a single data table in <b>.docx</b> Word document format, holding aggregated data on cardiovascular risk factors for men in Paramaribo, Suriname.<br>In related studies from 2013-2015, the population of Suriname was found to have a high cardiovascular risk factor burden. Around 40% of the general population was hypertensive, 15% had diabetes, and the large majority had one or more risk factors for cardiovascular disease. However, it was not possible to assess time trends in these risk factors as historical data were lacking. <br> This dataset holds rediscovered and hitherto unpublished aggregated data of what was apparently the first population study on measured blood pressure, diabetes, and cardiovascular health in men in Suriname, assessed in 1973. These are presented alongside 2013 data for the same variables. These data may help understand the cardiovascular risk factor escalation of the local population in time as well as aid in projections of future cardiovascular disease in this middle income country. <br>The variables reported in the data table are: sample size (%), sampling method, African ancestry (%), Regular leisure exercise (%), Ever smoked tobacco (%), Hypertension (%) and Diabetes (%).
DOI: 10.6084/m9.figshare.7203245.v1
title: newick tree used for Supplementary Figure 1

description: necessary to replicate Fig. S1 in https://github.com/KyleTDavid/NGS/blob/master/get_plots.R
DOI: 10.7284/131996
title: Winch data collected during research cruise SR1813 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7203029
title: Data set

description: Data sheet on attentional control theory<br>
DOI: 10.7284/131714
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SR1814 using a Hawaii UHDAS instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/131711
title: GNSS (Global Navigation Satellite System) data collected during research cruise SR1814 using a Trimble BD982 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7201340
title: Assessment of light transmission aggregometry on the routine coagulation analyzer Sysmex CS-2500 using CE-marked agonists from Hyphen Biomed

description: Light transmission aggregometry (LTA) is still considered as the “gold standard” for platelet function assessment but, as acompletely manual technology, it is labour intensive. This challenge can be overcome by performing platelet aggregometry in anautomated method on a routine coagulation analyzer. We aimed to compare and correlate results obtained from a traditional manual LTA solution realized in our Reference Center with an optimized automated system using CE-marked agonist reagents. Platelet rich plasma from patients with suspected platelet disorders, von Willebrand disease or antiplatelet therapy have been assessed using a wide range of agonist concentrations. Results were expressed as Maximal Platelet Aggregation and correlation was analyzed using the Passing and Bablok regression test. Platelet aggregometry studies were performed in 49 samples. Maximal aggregation response with ADP (0.5-10 μM), collagen (2 mg/μL), ristocetin (1.2 mg/mL) and arachidonic acid (1 mM) agonists showed significant correlation between the two aggregometers (p&lt; .001). We observed a more variable response using lowconcentrations of ADP (≤5 μM). Moreover, we also noted discrepancies with the low dose of ristocetin, showing excessive paradoxical agglutination with the CS-2500, suggesting that a lower ristocetin dose should be used with this system. These data show that CS-2500 has the advantages of a walk-away technology and the use of CE-marked reagents also permit the possibility of an easier certification.
DOI: 10.7284/131715
title: INS (Inertial Navigation System) data collected during research cruise SR1814 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition