cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24128526.v1
title: Predictive factors for prolonged sick leave in breast cancer patients treated with adjuvant therapies: a retrospective registry study

description: Being able to work during and after breast cancer treatments is important for patients to have a sense of normalcy, financial security, and improved quality of life, and for society due to the economic burden of sick leave. Factors influencing the length of sick leave can be sociodemographic factors, workplace adaptations, recurrences, symptoms, and type of treatment. The aim of this study is to analyse factors associated with prolonged sick leave after adjuvant breast cancer treatments. The population of this registry study consists of 1333 early breast cancer patients diagnosed and treated in Helsinki University Hospital between 2016 and 2018. Data on patient demographics, disease characteristics, treatment, and healthcare resource utilization were obtained from Helsinki University Hospital and data on income level and sick leave were obtained from Kela sickness benefits registry. Prolonged sick leave was determined as the patient accumulating 30 or more reimbursed sick leave days during a 60-day follow-up period after the end of active oncological treatment. Univariate analysis and multivariate analysis were conducted. A total of 26% of the patients in this study were on sick leave for 30 or more days after the active treatments ended. Study findings show that chemotherapy, triple-negative breast cancer, reconstructive surgery, amount of outpatient visits, and income are associated with prolonged sick leave. Independent predictors of prolonged sick leave were treatment line, number of outpatient contacts, reconstruction, and triple-negative breast cancer. Our study shows that prolonged sick leave affects a substantial number of working-age women with early breast cancer. Independent predictors for prolonged sick leave were all treatment-related. Targeted support for treatment-related side-effects already during the treatment period could lead to better recovery and earlier return to work.
DOI: 10.6084/m9.figshare.24148244
title: Body mass index and its association with 22 cancer types: a Norwegian cohort study of 481 202 cancer cases

description: Body mass index and its association with 22 cancer types: a Norwegian cohort study of 481 202 cancer cases
DOI: 10.6084/m9.figshare.24148244.v1
title: Body mass index and its association with 22 cancer types: a Norwegian cohort study of 481 202 cancer cases

description: Body mass index and its association with 22 cancer types: a Norwegian cohort study of 481 202 cancer cases
DOI: 10.6084/m9.figshare.24271802.v1
title: Locoregional breast radiotherapy including IMN: optimizing the dose distribution using an automated non-coplanar VMAT-technique

description: Volumetric Modulated Arc Therapy (VMAT) offers better conformity, homogeneity and sparing of the heart and ipsilateral lung for locoregional radiotherapy in left-sided breast cancer compared to three-dimensional conformal radiotherapy (3D-CRT). However, conventional coplanar VMAT (cVMAT) can result in higher doses to the normal tissue on the contralateral side. This study investigates a non-coplanar VMAT-technique (ncVMAT) to mitigate this issue. CT series of 20 left sided breast cancer patients were included for planning of locoregional breast radiotherapy including internal mammary nodes (IMN). Three treatment plans; 3D-CRT, cVMAT and ncVMAT, were generated for each patient with a prescription dose of 40.05 Gy in 15 fractions. Both VMAT-techniques consisted of a single arc in the axial plane, while ncVMAT included an additional arc in the sagittal plane. All plans were optimized to cover the clinical target volume (CTV) by 38.05 Gy for the breast and 36.05 Gy for lymph nodes, with as low as possible dose to organs at risk. Full CTV coverage was achieved for all plans. Both cVMAT and ncVMAT delivered more conformal and homogeneous target doses than 3D-CRT. Doses to the heart and ipsilateral lung were significantly lower with ncVMAT compared to both cVMAT and 3D-CRT. ncVMAT reduced doses to both the contralateral breast and lung compared to cVMAT and achieved levels similar to 3D-CRT for the contralateral breast and moderately higher doses for the contralateral lung. Delivery of high doses (&gt;30 Gy) to the contralateral side was completely avoided with ncVMAT, contrary to the results for cVMAT and 3D-CRT. ncVMAT reduced doses to the heart and ipsilateral lung as compared to both cVMAT and 3D-CRT. All contralateral dose metrics were reduced with the novel ncVMAT technique compared to cVMAT, and the mean contralateral breast doses were similar to 3D-CRT.
DOI: 10.6084/m9.figshare.24059211.v1
title: Temporal changes in childhood cancer incidence and survival by stage at diagnosis in Australia, 2000–2017

description: The Toronto Paediatric Cancer Stage Guidelines are a compendium of staging systems developed to facilitate collection of consistent and comparable data on stage at diagnosis for childhood cancers by cancer registries. This retrospective, observational cohort study investigated changes in stage-specific incidence and survival for children diagnosed between 2000-2008 compared to 2009-2017 using the population-based Australian Childhood Cancer Registry. Information on mortality for each patient was available to 31<sup>st</sup> December 2020. Shifts in incidence by stage were evaluated using chi-square tests, and differences in stage-specific five-year observed survival for all causes of death over time were assessed using flexible parametric models. Stage was assigned according to the Toronto Guidelines for 96% (<i>n</i> = 7944) of the total study cohort (<i>n</i> = 8292). Changes in the distribution of incidence by stage between the two diagnosis periods were observed for retinoblastoma, with stage 0 increasing from 26% to 37% of cases (<i>p</i> = 0.02), and hepatoblastoma, with metastatic disease increasing from 22% to 39% of cases (p = 0.04). There were large gains in stage-specific survival over time for stage IV rhabdomyosarcoma (five-year adjusted mortality hazard ratio for 2009–2017 compared to 2000–2008 of 0.38, 95% CI 0.19–0.77; <i>p</i> = 0.01), stage M3 for medulloblastoma (HR = 0.41, 95% CI 0.21–0.79; <i>p</i> = 0.01) and metastatic neuroblastoma excluding stage MS (HR = 0.61, 95% CI 0.44-0.84; <i>p</i> &lt; 0.01). These results indicate that improvements in childhood cancer survival in Australia are most likely due to refined management rather than changes in stage at diagnosis, particularly for metastatic solid tumours. Wide international uptake of the Toronto Guidelines will allow comprehensive evaluation of differences in survival between countries.
DOI: 10.6084/m9.figshare.24271802
title: Locoregional breast radiotherapy including IMN: optimizing the dose distribution using an automated non-coplanar VMAT-technique

description: Volumetric Modulated Arc Therapy (VMAT) offers better conformity, homogeneity and sparing of the heart and ipsilateral lung for locoregional radiotherapy in left-sided breast cancer compared to three-dimensional conformal radiotherapy (3D-CRT). However, conventional coplanar VMAT (cVMAT) can result in higher doses to the normal tissue on the contralateral side. This study investigates a non-coplanar VMAT-technique (ncVMAT) to mitigate this issue. CT series of 20 left sided breast cancer patients were included for planning of locoregional breast radiotherapy including internal mammary nodes (IMN). Three treatment plans; 3D-CRT, cVMAT and ncVMAT, were generated for each patient with a prescription dose of 40.05 Gy in 15 fractions. Both VMAT-techniques consisted of a single arc in the axial plane, while ncVMAT included an additional arc in the sagittal plane. All plans were optimized to cover the clinical target volume (CTV) by 38.05 Gy for the breast and 36.05 Gy for lymph nodes, with as low as possible dose to organs at risk. Full CTV coverage was achieved for all plans. Both cVMAT and ncVMAT delivered more conformal and homogeneous target doses than 3D-CRT. Doses to the heart and ipsilateral lung were significantly lower with ncVMAT compared to both cVMAT and 3D-CRT. ncVMAT reduced doses to both the contralateral breast and lung compared to cVMAT and achieved levels similar to 3D-CRT for the contralateral breast and moderately higher doses for the contralateral lung. Delivery of high doses (&gt;30 Gy) to the contralateral side was completely avoided with ncVMAT, contrary to the results for cVMAT and 3D-CRT. ncVMAT reduced doses to the heart and ipsilateral lung as compared to both cVMAT and 3D-CRT. All contralateral dose metrics were reduced with the novel ncVMAT technique compared to cVMAT, and the mean contralateral breast doses were similar to 3D-CRT.
DOI: 10.6084/m9.figshare.24059211
title: Temporal changes in childhood cancer incidence and survival by stage at diagnosis in Australia, 2000–2017

description: The Toronto Paediatric Cancer Stage Guidelines are a compendium of staging systems developed to facilitate collection of consistent and comparable data on stage at diagnosis for childhood cancers by cancer registries. This retrospective, observational cohort study investigated changes in stage-specific incidence and survival for children diagnosed between 2000-2008 compared to 2009-2017 using the population-based Australian Childhood Cancer Registry. Information on mortality for each patient was available to 31<sup>st</sup> December 2020. Shifts in incidence by stage were evaluated using chi-square tests, and differences in stage-specific five-year observed survival for all causes of death over time were assessed using flexible parametric models. Stage was assigned according to the Toronto Guidelines for 96% (<i>n</i> = 7944) of the total study cohort (<i>n</i> = 8292). Changes in the distribution of incidence by stage between the two diagnosis periods were observed for retinoblastoma, with stage 0 increasing from 26% to 37% of cases (<i>p</i> = 0.02), and hepatoblastoma, with metastatic disease increasing from 22% to 39% of cases (p = 0.04). There were large gains in stage-specific survival over time for stage IV rhabdomyosarcoma (five-year adjusted mortality hazard ratio for 2009–2017 compared to 2000–2008 of 0.38, 95% CI 0.19–0.77; <i>p</i> = 0.01), stage M3 for medulloblastoma (HR = 0.41, 95% CI 0.21–0.79; <i>p</i> = 0.01) and metastatic neuroblastoma excluding stage MS (HR = 0.61, 95% CI 0.44-0.84; <i>p</i> &lt; 0.01). These results indicate that improvements in childhood cancer survival in Australia are most likely due to refined management rather than changes in stage at diagnosis, particularly for metastatic solid tumours. Wide international uptake of the Toronto Guidelines will allow comprehensive evaluation of differences in survival between countries.
DOI: 10.5281/zenodo.10712479
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.5281/zenodo.10724528
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.5281/zenodo.10762427
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.5281/zenodo.10762621
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.5281/zenodo.10850169
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.5281/zenodo.10764508
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.5281/zenodo.10788281
title: AVDATA-BR-CP - Brazilian Aviation Data - City-Pairs

description: This dataset is named AVDATA-BR-CP, with the "CP" suffix denoting a collection of Brazilian aviation data organized by domestic city pairs in Brazil ("CP" stands for "city pairs"), updated on a monthly basis. The primary source of this data is the National Civil Aviation Agency (ANAC). The data and variables used are described in Oliveira, A. V. M. (2024), in the paper titled "AVDATABR: An Open Database for Brazilian Air Transport", published in Communications in Airline Economics Research, volume 1, article 10671652, available at https://zenodo.org/doi/10.5281/zenodo.10671652.
DOI: 10.6084/m9.figshare.25451986
title: PMF-GRN: a Variational inference approach to single-cell gene regulatory network inference using probabilistic matrix factorization

description: Datasets used in the PMF-GRN manuscript
DOI: 10.34740/kaggle/dsv/7908089
title: Top Spotify Songs in 73 Countries (Daily Updated)
DOI: 10.34740/kaggle/dsv/7908097
title: Trending Youtube Video Statistics (113 Countries)
DOI: 10.34740/kaggle/dsv/7908100
title: Full TMDB Movies Dataset 2024 (1M Movies)
DOI: 10.7294/23739405.v1
title: Idealized cross-shore XBeach simulations of storm-induced barrier island change with varying subaerial profile and sediment mobility characteristics

description: Six thousand, four hundred and fourty four (6,444) two-dimensional, cross-shore computational simulations were carried out with the open computational model XBeach (Roelvink et al., 2009, Coastal Engineering; https://oss.deltares.nl/web/xbeach/) to investigate the influence of subaerial barrier-island profile shape and sediment mobility on barrier-island morphological response during coastal storms; results are presented in Irish et al. (2024; DOI: 10.1061/JWPED5/WWENG-2047). All simulations were forced at the offshore boundary (25-m depth) with (1) a 6-hr sinusoid storm surge timeseries varying from 1 m, Mean Sea Level (MSL) up to the provided Peak Surge value then returning to 1 m and (2) JONSWAP wave spectra with significant wave height and peak period respectively of 8 m and 10 s. Initial barrier island profiles, final XBeach-simulated barrier island profiles, varied XBeach input parameters, and output parameters calculated from the initial and final profiles are provided herein. Three sediment grain size distributions were considered, with distribution specified by median and 90th percentile, respectively: (0.2 mm, 0.3 mm), (0.4 mm,0.6 mm), and (0.6, 0.8 mm). All other XBeach input parameters were set to their default values. Four csv files are included within the zipped archive XBeachInputOutput_Irish_etal2023.zip, as discussed below.<br>Related research paper citation:Irish, J. L., Cheng, W., Weiss, R., Patch, S. M., Beever, M. A. (2024). Influence of belowground biomass on barrier-island evolution during storms: A computational parameter study. DOI: 10.1061/JWPED5/WWENG-2047<br>
DOI: 10.7294/23739405
title: Idealized cross-shore XBeach simulations of storm-induced barrier island change with varying subaerial profile and sediment mobility characteristics

description: Six thousand, four hundred and fourty four (6,444) two-dimensional, cross-shore computational simulations were carried out with the open computational model XBeach (Roelvink et al., 2009, Coastal Engineering; https://oss.deltares.nl/web/xbeach/) to investigate the influence of subaerial barrier-island profile shape and sediment mobility on barrier-island morphological response during coastal storms; results are presented in Irish et al. (2024; DOI: 10.1061/JWPED5/WWENG-2047). All simulations were forced at the offshore boundary (25-m depth) with (1) a 6-hr sinusoid storm surge timeseries varying from 1 m, Mean Sea Level (MSL) up to the provided Peak Surge value then returning to 1 m and (2) JONSWAP wave spectra with significant wave height and peak period respectively of 8 m and 10 s. Initial barrier island profiles, final XBeach-simulated barrier island profiles, varied XBeach input parameters, and output parameters calculated from the initial and final profiles are provided herein. Three sediment grain size distributions were considered, with distribution specified by median and 90th percentile, respectively: (0.2 mm, 0.3 mm), (0.4 mm,0.6 mm), and (0.6, 0.8 mm). All other XBeach input parameters were set to their default values. Four csv files are included within the zipped archive XBeachInputOutput_Irish_etal2023.zip, as discussed below.<br>Related research paper citation:Irish, J. L., Cheng, W., Weiss, R., Patch, S. M., Beever, M. A. (2024). Influence of belowground biomass on barrier-island evolution during storms: A computational parameter study. DOI: 10.1061/JWPED5/WWENG-2047<br>
DOI: 10.6084/m9.figshare.23925458
title: A systematic review on clinical adaptive radiotherapy for head and neck cancer

description: Head and neck cancer (HNC) patients’ anatomy may undergo significant changes during radiotherapy (RT). This potentially affects dose distribution and compromises conformity between planned and delivered dose. Adaptive radiotherapy (ART) is a promising technique to overcome this problem but requires a significant workload. This systematic review aims to estimate the clinical and dosimetric benefits of ART using prospective data. A search on PubMed and Web of Science according to the PRISMA guidelines was made on Feb 6, 2023. Search string used was: ‘adaptive radiotherapy head neck cancer’. English language filter was applied. All studies were screened for inclusion on title and abstract, and the full text was read and discussed in the research group in case of uncertainty. Inclusion criteria were a prospective ART strategy for HNC investigating clinical or dosimetric outcomes. A total of 1251 articles were identified of which 15 met inclusion criteria. All included studies were published between 2010 and 2023 with a substantial diversity in design, endpoints, and nomenclature. The number of patients treated with ART was small with a median of 20 patients per study (range 4 to 86), undergoing 1-2 replannings. Mean dose to the parotid glands was reduced by 0.4-7.1 Gy. Maximum dose to the spinal cord was reduced by 0.5-4.6 Gy. Only five studies reported clinical outcome and disease control was excellent. Data on toxicity were ambiguous with some studies indicating reduced acute toxicity and xerostomia, while others found reduced quality of life in patients treated with ART. The literature on clinical ART in HNC is limited. ART is associated with small reductions in doses to organs at risk, but the influence on toxicity and disease control is uncertain. There is a clear need for larger, prospective trials with a well-defined control group.
DOI: 10.6084/m9.figshare.23925458.v1
title: A systematic review on clinical adaptive radiotherapy for head and neck cancer

description: Head and neck cancer (HNC) patients’ anatomy may undergo significant changes during radiotherapy (RT). This potentially affects dose distribution and compromises conformity between planned and delivered dose. Adaptive radiotherapy (ART) is a promising technique to overcome this problem but requires a significant workload. This systematic review aims to estimate the clinical and dosimetric benefits of ART using prospective data. A search on PubMed and Web of Science according to the PRISMA guidelines was made on Feb 6, 2023. Search string used was: ‘adaptive radiotherapy head neck cancer’. English language filter was applied. All studies were screened for inclusion on title and abstract, and the full text was read and discussed in the research group in case of uncertainty. Inclusion criteria were a prospective ART strategy for HNC investigating clinical or dosimetric outcomes. A total of 1251 articles were identified of which 15 met inclusion criteria. All included studies were published between 2010 and 2023 with a substantial diversity in design, endpoints, and nomenclature. The number of patients treated with ART was small with a median of 20 patients per study (range 4 to 86), undergoing 1-2 replannings. Mean dose to the parotid glands was reduced by 0.4-7.1 Gy. Maximum dose to the spinal cord was reduced by 0.5-4.6 Gy. Only five studies reported clinical outcome and disease control was excellent. Data on toxicity were ambiguous with some studies indicating reduced acute toxicity and xerostomia, while others found reduced quality of life in patients treated with ART. The literature on clinical ART in HNC is limited. ART is associated with small reductions in doses to organs at risk, but the influence on toxicity and disease control is uncertain. There is a clear need for larger, prospective trials with a well-defined control group.
DOI: 10.6084/m9.figshare.24148349
title: CBCT-based online adaptive radiotherapy for head and neck cancer – dosimetric evaluation of first clinical experience

description: CBCT-based online adaptive radiotherapy for head and neck cancer – dosimetric evaluation of first clinical experience
DOI: 10.6084/m9.figshare.24148349.v1
title: CBCT-based online adaptive radiotherapy for head and neck cancer – dosimetric evaluation of first clinical experience

description: CBCT-based online adaptive radiotherapy for head and neck cancer – dosimetric evaluation of first clinical experience