cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23803374.v1
title: Supplementary Material for: Long-term trajectories of biomarkers, functional, and echocardiographic parameters in patients with chronic heart failure from dilated or ischaemic cardiomyopathy

description: Introduction: The long-term evolution of clinical, echocardiographic and laboratory parameters of cardiac function in patients with chronic heart failure (HF) with either reduced (HFrEF) or mildly reduced (HFmrEF) left ventricular ejection fraction (LVEF) is incompletely characterized. Methods: We identified patients with chronic stable HF who presented at least twice to a university HF outpatient clinic between 1995 and 2021. Trajectories of NYHA functional class, LVEF, left ventricular internal enddiastolic diameter (LVIDD), NT-proBNP concentrations and HF treatment over ten years follow-up were analysed using fractional polynomials. Analyses were repeated after stratifying patients according to aetiology (ischemic vs. dilated) or HF category (HFrEF vs. HFmrEF). Results: A total of 2,132 patients were included, of whom 51% had ischemic and 49% had dilated HF. 86% and 14% were classified as HFrEF and HFmrEF, respectively. Mean LVEF was 28±10%, and median NT-proBNP and eGFR values were 1,170 (385-3,176) pmol/L and 81 (62-100) ml/min/1.73m², respectively. Median follow-up was 5.2 (2.6-9.2) years. Overall, NYHA functional class and LVIDD trajectories were U-shaped, whereas LVEF and NT-proBNP concentrations markedly improved during the first year and remained stable thereafter. However, the evolution of HF parameters significantly differed with respect to HF category and aetiology, with greater improvements seen in patients with HFrEF of non-ischemic origin. Improvements in HF variables were associated with optimization of HF therapy, notably with initiation and up-titration of renin-angiotensin-system blockers. Discussion/Conclusion: This study provides insights into the natural history of HF in a large cohort of well-treated chronic HF outpatients with respect to subgroups of HF and different etiologist.
DOI: 10.6084/m9.figshare.23803380
title: Supplementary Material for: Long-term trajectories of biomarkers, functional, and echocardiographic parameters in patients with chronic heart failure from dilated or ischaemic cardiomyopathy

description: Introduction: The long-term evolution of clinical, echocardiographic and laboratory parameters of cardiac function in patients with chronic heart failure (HF) with either reduced (HFrEF) or mildly reduced (HFmrEF) left ventricular ejection fraction (LVEF) is incompletely characterized. Methods: We identified patients with chronic stable HF who presented at least twice to a university HF outpatient clinic between 1995 and 2021. Trajectories of NYHA functional class, LVEF, left ventricular internal enddiastolic diameter (LVIDD), NT-proBNP concentrations and HF treatment over ten years follow-up were analysed using fractional polynomials. Analyses were repeated after stratifying patients according to aetiology (ischemic vs. dilated) or HF category (HFrEF vs. HFmrEF). Results: A total of 2,132 patients were included, of whom 51% had ischemic and 49% had dilated HF. 86% and 14% were classified as HFrEF and HFmrEF, respectively. Mean LVEF was 28±10%, and median NT-proBNP and eGFR values were 1,170 (385-3,176) pmol/L and 81 (62-100) ml/min/1.73m², respectively. Median follow-up was 5.2 (2.6-9.2) years. Overall, NYHA functional class and LVIDD trajectories were U-shaped, whereas LVEF and NT-proBNP concentrations markedly improved during the first year and remained stable thereafter. However, the evolution of HF parameters significantly differed with respect to HF category and aetiology, with greater improvements seen in patients with HFrEF of non-ischemic origin. Improvements in HF variables were associated with optimization of HF therapy, notably with initiation and up-titration of renin-angiotensin-system blockers. Discussion/Conclusion: This study provides insights into the natural history of HF in a large cohort of well-treated chronic HF outpatients with respect to subgroups of HF and different etiologist.
DOI: 10.6084/m9.figshare.23803380.v1
title: Supplementary Material for: Long-term trajectories of biomarkers, functional, and echocardiographic parameters in patients with chronic heart failure from dilated or ischaemic cardiomyopathy

description: Introduction: The long-term evolution of clinical, echocardiographic and laboratory parameters of cardiac function in patients with chronic heart failure (HF) with either reduced (HFrEF) or mildly reduced (HFmrEF) left ventricular ejection fraction (LVEF) is incompletely characterized. Methods: We identified patients with chronic stable HF who presented at least twice to a university HF outpatient clinic between 1995 and 2021. Trajectories of NYHA functional class, LVEF, left ventricular internal enddiastolic diameter (LVIDD), NT-proBNP concentrations and HF treatment over ten years follow-up were analysed using fractional polynomials. Analyses were repeated after stratifying patients according to aetiology (ischemic vs. dilated) or HF category (HFrEF vs. HFmrEF). Results: A total of 2,132 patients were included, of whom 51% had ischemic and 49% had dilated HF. 86% and 14% were classified as HFrEF and HFmrEF, respectively. Mean LVEF was 28±10%, and median NT-proBNP and eGFR values were 1,170 (385-3,176) pmol/L and 81 (62-100) ml/min/1.73m², respectively. Median follow-up was 5.2 (2.6-9.2) years. Overall, NYHA functional class and LVIDD trajectories were U-shaped, whereas LVEF and NT-proBNP concentrations markedly improved during the first year and remained stable thereafter. However, the evolution of HF parameters significantly differed with respect to HF category and aetiology, with greater improvements seen in patients with HFrEF of non-ischemic origin. Improvements in HF variables were associated with optimization of HF therapy, notably with initiation and up-titration of renin-angiotensin-system blockers. Discussion/Conclusion: This study provides insights into the natural history of HF in a large cohort of well-treated chronic HF outpatients with respect to subgroups of HF and different etiologist.
DOI: 10.6084/m9.figshare.23119835
title: Sample QM/MM files for "Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1-OH∙∙∙Nucleophile in Transition State Stabilization in Arabidopsis thaliana Cell Wall Invertase 1"

description: This dataset accompanies the manuscript: " <i>Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1-OH∙∙∙Nucleophile in Transition State Stabilization in Arabidopsise thaliana Cell Wall Invertase 1</i>".<br>It contains sample CHARMM input and output files, topologies, and parameters required for QM/MM calculations of reaction in a plant cell-wall invertase.<br><b>The QM/MM inputs include:</b>1. QM/MM MD simulation2. Energy minimization3. Reaction path calculation (adiabatic mapping)4. Umbrella sampling MD along reaction coordinate (PMF computations)<br><b>The outputs from QM/MM umbrella sampling MD include:</b>Snapshots of stationary points on the PMF plots in Figure 3A for sucrose hydrolysis catalyzed by a plant cell-wall invertase 1 from <i>Arabidopsise thaliana </i>(see Figure 3 in the main text, DOI: 10.1021/acs.jcim.3c00796)Trajectories from the last 40 ps of 100-ps umbrella sampling simulations<br><br><br><br><br><br><br><br>
DOI: 10.6084/m9.figshare.23119835.v1
title: Sample QM/MM files for "Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1-OH∙∙∙Nucleophile in Transition State Stabilization in Arabidopsis thaliana Cell Wall Invertase 1"

description: This dataset accompanies the manuscript: " <i>Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1-OH∙∙∙Nucleophile in Transition State Stabilization in Arabidopsise thaliana Cell Wall Invertase 1</i>".<br>It contains sample CHARMM input and output files, topologies, and parameters required for QM/MM calculations of reaction in a plant cell-wall invertase.<br><b>The QM/MM inputs include:</b>1. QM/MM MD simulation2. Energy minimization3. Reaction path calculation (adiabatic mapping)4. Umbrella sampling MD along reaction coordinate (PMF computations)<br><b>The outputs from QM/MM umbrella sampling MD include:</b>Snapshots of stationary points on the PMF plots in Figure 3A for sucrose hydrolysis catalyzed by a plant cell-wall invertase 1 from <i>Arabidopsise thaliana </i>(see Figure 3 in the main text, DOI: 10.1021/acs.jcim.3c00796)Trajectories from the last 40 ps of 100-ps umbrella sampling simulations<br><br><br><br><br><br><br><br>
DOI: 10.5281/zenodo.8194819
title: SENG 480B - Final Project

description: SENG 480B final project files described in 'Appendix A' section of final report.
DOI: 10.5281/zenodo.8194818
title: SENG 480B - Final Project

description: SENG 480B final project files described in 'Appendix A' section of final report.
DOI: 10.6084/m9.figshare.22189276.v3
title: Glacial-interglacial circulation and climatic changes in the South Indian Ocean (Kerguelen Plateau region) recorded by detrital and biogenic magnetites

description: Magnetic susceptibility, anhysteretic remanent magnetization, the ratio of anhysteretic remanent magnetization and magnetic susceptibility, saturation magnetization, and saturation isothermal remanent magnetization of the MD11-3353 core over the past 150 kyrs.
DOI: 10.6084/m9.figshare.22189276.v4
title: <b>Glacial-interglacial circulation and climatic changes in the South Indian Ocean </b><b>(Kerguelen Plateau region)</b><b> </b><b>recorded by detrital and biogenic </b><b>magnetic minerals</b>

description: Magnetic susceptibility, anhysteretic remanent magnetization, the ratio of anhysteretic remanent magnetization susceptibility and magnetic susceptibility, saturation magnetization, saturation isothermal remanent magnetization, and hard isothermal remanent magnetization of the MD11-3353 core over the past 150 kyrs.
DOI: 10.34740/kaggle/dsv/5389390
title: Tomatoes Dataset
DOI: 10.6084/m9.figshare.21936046
title: Making sense of competency-based medical education (CBME) literary conversations: A BEME scoping review: BEME Guide No. 78

description: Competency-based medical education (CBME) received increased attention in the early 2000s by educators, clinicians, and policy makers as a way to address concerns about physician preparedness and patient safety in a rapidly changing healthcare environment. Opinions and perspectives around this shift in medical education vary and, to date, a systematic search and synthesis of the literature has yet to be undertaken. The aim of this scoping review is to present a comprehensive map of the literary conversations surrounding CBME. Twelve different databases were searched from database inception up until 29 April 2020. Literary conversations were extracted into the following categories: perceived advantages, perceived disadvantages, challenges/uncertainties/skepticism, and recommendations related to CBME. Of the 5757 identified records, 387 were included in this review. Through thematic analysis, eight themes were identified in the literary conversations about CBME: credibility, application, community influence, learner impact, assessment, educational developments, organizational structures, and societal impacts of CBME. Content analysis supported the development of a heat map that provides a visual illustration of the frequency of these literary conversations over time. This review serves two purposes for the medical education research community. First, this review acts as a comprehensive historical record of the shifting perceptions of CBME as the construct was introduced and adopted by many groups in the medical education global community over time. Second, this review consolidates the many literary conversations about CBME that followed the initial proposal for this approach. These findings can facilitate understanding of CBME for multiple audiences both within and outside of the medical education research community.
DOI: 10.6084/m9.figshare.21936046.v1
title: Making sense of competency-based medical education (CBME) literary conversations: A BEME scoping review: BEME Guide No. 78

description: Competency-based medical education (CBME) received increased attention in the early 2000s by educators, clinicians, and policy makers as a way to address concerns about physician preparedness and patient safety in a rapidly changing healthcare environment. Opinions and perspectives around this shift in medical education vary and, to date, a systematic search and synthesis of the literature has yet to be undertaken. The aim of this scoping review is to present a comprehensive map of the literary conversations surrounding CBME. Twelve different databases were searched from database inception up until 29 April 2020. Literary conversations were extracted into the following categories: perceived advantages, perceived disadvantages, challenges/uncertainties/skepticism, and recommendations related to CBME. Of the 5757 identified records, 387 were included in this review. Through thematic analysis, eight themes were identified in the literary conversations about CBME: credibility, application, community influence, learner impact, assessment, educational developments, organizational structures, and societal impacts of CBME. Content analysis supported the development of a heat map that provides a visual illustration of the frequency of these literary conversations over time. This review serves two purposes for the medical education research community. First, this review acts as a comprehensive historical record of the shifting perceptions of CBME as the construct was introduced and adopted by many groups in the medical education global community over time. Second, this review consolidates the many literary conversations about CBME that followed the initial proposal for this approach. These findings can facilitate understanding of CBME for multiple audiences both within and outside of the medical education research community.
DOI: 10.15151/esrf-es-1303734776
title: Test measurements (NdCeLa)FeB and Fe-Pt thin films

description: The idea is to carry out test measurements (SAXS ans WAXS) on various samples deposited on Si substrates
DOI: 10.6084/m9.figshare.23803461
title: Persimmon image dataset

description: This persimmon image dataset consists of 800 training set and 200 validation set. This dataset had been used to train CNN for a low-cost machine vision system designed to flip the persimmons automatically in the real persimmon industry.The size of the training images : 416 x 416The size of the validation images : 3024 x 4032 (non-resizing images)
DOI: 10.6084/m9.figshare.23803581
title: dataset

description: The dataset provided gives detailed account of the effect of the drug on both maternal and neonatal outcome.
DOI: 10.6084/m9.figshare.23803653
title: Supplementary Material for: Circadian clock genes are regulated by rhythmic corticosterone at physiological levels in the rat hippocampus

description: Introduction: In the hippocampus, clock gene expression is important for memory and mood; however, the signaling mechanism controlling clock gene expression in the hippocampus is unknown. Recent findings suggest that circadian glucocorticoid rhythms driven by the suprachiasmatic nucleus (SCN) control rhythmic clock gene expression in neurons; in addition, dexamethasone modulates hippocampal clock gene expression. We therefore hypothesized that oscillations of clock genes in the hippocampus could be driven by SCN-controlled circadian rhythms in glucocorticoids. Methods: Temporal profiles of hippocampal clock gene expression were established by qRT-PCR on rat hippocampi, while cellular distribution was established by in situ hybridization. To determine the effect of rhythmic glucocorticoids on hippocampal clock gene expression, the SCN was lesioned, adrenal glands removed and a 24h exogenous corticosterone rhythm at physiological levels was reestablished by use of a programmable infusion pump. Results: Daily rhythms were detected for Per1, Per2, Bmal1, Nr1d1, and Dbp, while clock gene products were confirmed in both the hippocampus proper and the dentate gyrus. In sham controls, differential hippocampal expression of Per1 and Dbp between ZT3 and ZT15 was detectable. This rhythm was abolished by SCN-lesion; however, reestablishing the natural rhythm in corticosterone restored differential rhythmic expression of both Per1 and Dbp. Further, a 6h phase-delay in the corticosterone profile caused a predictable shift in expression of Nr1d1. Conclusion: Our data show that rhythmic corticosterone can drive hippocampal clock gene rhythms suggesting that the SCN regulates the circadian oscillator of the hippocampus by controlling the circadian rhythm in circulating glucocorticoids.
DOI: 10.5281/zenodo.8194943
title: Appendix: Ferdinando Calori Cesis' transcription errors in the Modena inventory of Pico della Mirandola's library

description: This Appendix presents the complete list of Ferdinando Calori Cesis’ transcription errors in the Modena inventory of Pico della Mirandola’s library. The Appendix accompanies the article titled "First-language transfer in the copying of Latin manuscripts: the case of Ferdinando Calori Cesis’ transcription of the Modena inventory of Pico della Mirandola’s library", to be published in the Nordic Journal of Renaissance Studies (2024). The columns contain the following information: 1) identifier number, 2) the reading of the inventory followed by Calori Cesis' transcription, separated by a square bracket, 3) whether the error is related to a(n Arabic) number or whether it is an omission, 4) the linguistic classification of the error, 5) whether the error is due to a hypercorrection, 6) whether it involves the transcription of j as i, 7) whether it involves the transcription of u as v, 8) whether it involves the transcription of y as i, and 9) whether the word involves h.
DOI: 10.5281/zenodo.8194942
title: Appendix: Ferdinando Calori Cesis' transcription errors in the Modena inventory of Pico della Mirandola's library

description: This Appendix presents the complete list of Ferdinando Calori Cesis’ transcription errors in the Modena inventory of Pico della Mirandola’s library. The Appendix accompanies the article titled "First-language transfer in the copying of Latin manuscripts: the case of Ferdinando Calori Cesis’ transcription of the Modena inventory of Pico della Mirandola’s library", to be published in the Nordic Journal of Renaissance Studies (2024). The columns contain the following information: 1) identifier number, 2) the reading of the inventory followed by Calori Cesis' transcription, separated by a square bracket, 3) whether the error is related to a(n Arabic) number or whether it is an omission, 4) the linguistic classification of the error, 5) whether the error is due to a hypercorrection, 6) whether it involves the transcription of j as i, 7) whether it involves the transcription of u as v, 8) whether it involves the transcription of y as i, and 9) whether the word involves h.
DOI: 10.6084/m9.figshare.23803679.v1
title: Hydrodynamic pressures on a stepped spillway with an aerator system subjected to different air flow rates

description: ABSTRACT Aerator systems promote additional insertion of air into the flow and can reduce the risk of cavitation and consequent damage to hydraulic structures. This work analyzes the hydrodynamic pressures on the steps of a physical model (with a chute inclination of 53.13º) subjected to different aeration conditions. When comparing the results with different air intake coefficients in the flow, it was concluded that the incorporation of air does not change in a generalized way all the statistical parameters associated with hydrodynamic pressures on the steps. However, with the insertion of air in the flow, there was an increase in the minimum pressure values measured in the region of the jet impact and downstream. Empirical equations for predicting the distribution of pressures on the steps under induced aeration conditions were proposed, valid for structures whose ratio between the height of the deflector and the height of the steps is equal to 0.167, with an aerator system installed at the beginning of the stepped chute.
DOI: 10.6084/m9.figshare.23803679
title: Hydrodynamic pressures on a stepped spillway with an aerator system subjected to different air flow rates

description: ABSTRACT Aerator systems promote additional insertion of air into the flow and can reduce the risk of cavitation and consequent damage to hydraulic structures. This work analyzes the hydrodynamic pressures on the steps of a physical model (with a chute inclination of 53.13º) subjected to different aeration conditions. When comparing the results with different air intake coefficients in the flow, it was concluded that the incorporation of air does not change in a generalized way all the statistical parameters associated with hydrodynamic pressures on the steps. However, with the insertion of air in the flow, there was an increase in the minimum pressure values measured in the region of the jet impact and downstream. Empirical equations for predicting the distribution of pressures on the steps under induced aeration conditions were proposed, valid for structures whose ratio between the height of the deflector and the height of the steps is equal to 0.167, with an aerator system installed at the beginning of the stepped chute.
DOI: 10.6084/m9.figshare.23803681
title: Cost analysis of GenoType® MTBDRplus and GenoType® MTBDRsl at the State Laboratory of São Paulo, Brazil

description: ABSTRACT Background: We aimed to evaluate the costs of GenoType® MTBDRplus and MTBDRsl incurred during the diagnosis of first- and second-line drug-resistant tuberculosis (TB) in São Paulo, Brazil. Methods: Mean and activity-based costs of GenoType® were calculated in a referral laboratory for TB in Brazil. Results: The mean cost value and activity-based cost of GenoType® MTBDRplus were USD 19.78 and USD 35.80 and those of MTBDRsl were USD 54.25 and USD 41.85, respectively. Conclusions: The cost of GenoType® MTBDRplus was reduced owing to the high number of examinations performed and work optimization.
DOI: 10.6084/m9.figshare.23803681.v1
title: Cost analysis of GenoType® MTBDRplus and GenoType® MTBDRsl at the State Laboratory of São Paulo, Brazil

description: ABSTRACT Background: We aimed to evaluate the costs of GenoType® MTBDRplus and MTBDRsl incurred during the diagnosis of first- and second-line drug-resistant tuberculosis (TB) in São Paulo, Brazil. Methods: Mean and activity-based costs of GenoType® were calculated in a referral laboratory for TB in Brazil. Results: The mean cost value and activity-based cost of GenoType® MTBDRplus were USD 19.78 and USD 35.80 and those of MTBDRsl were USD 54.25 and USD 41.85, respectively. Conclusions: The cost of GenoType® MTBDRplus was reduced owing to the high number of examinations performed and work optimization.
DOI: 10.6084/m9.figshare.23702006
title: Fertilization strategies to reduce the formation of stenospermocarpic mango fruits in the semiarid region

description: Abstract The mango cultivation has shown considerable losses, due to the intense occurrence of physiological disorders in its fruits, and stenospermocarpy is the main disorder under tropical semiarid conditions. So, the experiment was carried out to evaluate the potential loss of yield of mango cv. Palmer by stenospermocarpy, its relation with the nutritional state of the plant and yield as a function of fertilization strategies. The study was conducted in two experimental areas in the Brazilian semiarid. There is evidence that the leaf contents of phosphorus (P), iron (Fe) and zinc (Zn) influenced the development of stenospermocarpy fruits, associated with high temperature and low relative humidity in the flowering period of the crop. The incidence of fruits affected by stenospermocarpy reaches 90%, with an estimated yield loss of 28.81 Mg ha-1 for the mango cv. Palmer.