cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13141412.v1
title: Supplementary Material for: Biomarkers of Unfavorable Outcome in Acute Ischemic Stroke Patients with Successful Recanalization by Endovascular Thrombectomy

description: <b><i>Background:</i></b> We aimed to identify plasma markers of unfavorable outcomes for patients with acute ischemic stroke (AIS) after recanalization by endovascular thrombectomy (EVT). <b><i>Methods:</i></b> From November 2017 to May 2019, we prospectively collected 61 AIS patients due to anterior large vessel occlusion who achieved recanalization by EVT. Plasma samples were obtained between 18 and 24 h after recanalization. Unfavorable outcomes included futile recanalization at 90 days and overall early complications within 7 days after EVT. <b><i>Results:</i></b> After adjustment for age and initial National Institute of Health Stroke Scale (NIHSS), matrix metalloproteinase-9 (MMP-9), tenascin-C, thioredoxin, ADAMTS13, and gelsolin were independently associated with both futile recanalization and overall early complications significantly (all <i>p</i> &lt; 0.05), while C-reactive protein (CRP) was independently associated with overall early complications (<i>p</i> = 0.031) but at the limit of significance for futile recanalization (<i>p</i> = 0.051). The baseline clinical model (BCM) (including age and initial NIHSS) demonstrated discriminating ability to indicate futile recanalization (area under the curve [AUC] 0.807, 95% confidence interval [CI] 0.693–0.921) and overall early complications (AUC 0.749, 95% CI 0.611–0.887). BCM+MMP-9+thioredoxin enhanced discrimination (AUC 0.908, 95% CI 0.839–0.978, <i>p</i> = 0.043) and reclassification (net reclassification improvement [NRI] 67.2%, <i>p</i> &lt; 0.001) to indicate futile recanalization. With respect to overall early complications, BCM+MMP-9+tenascin-C, BCM+MMP-9+CRP, BCM+MMP-9+ADAMTS13, BCM+tenascin-C+ADAMTS13, and BCM+CRP+ADAMTS13, all improved discrimination (AUC [95% CI]: 0.868 [0.766–0.970], 0.882 [0.773–0.990], 0.886 [0.788–0.984], 0.880 [0.783–0.977], and 0.863 [0.764–0.962], respectively, all <i>p</i> &lt; 0.05 by the DeLong method) and reclassification (NRI 59.1%, 71.8%, 51.1%, 67.4%, and 38.3%, respectively, all <i>p</i> &lt; 0.05). <b><i>Conclusions:</i></b> The increased levels of MMP-9, tenascin-C, CRP, thioredoxin, and decreased levels of ADAMTS13 and gelsolin were independent predictors of futile recanalization in AIS patients after recanalization by EVT.
DOI: 10.6084/m9.figshare.13141409
title: Supplementary Material for: Acute Kidney Disease Increases the Risk of Post-Kidney Biopsy Bleeding Complications

description: <b><i>Introduction:</i></b> Kidney biopsy, providing the insightful information for most kidney diseases, is an invasive diagnostic tool with certain risks ranging from the least severe macroscopic hematuria to the most severe life-threatening bleeding necessitating renal artery embolization. We aimed to compare the postbiopsy bleeding complications between 2 common methods and to further explore the risk factors of bleeding complications in patients using the negative pressure suction puncture (NPS) method. <b><i>Methods:</i></b> We retrospectively collected the data from percutaneous native kidney biopsies in 2016. The clinical, laboratory tests, pathological findings, and the occurrence of bleeding complications following kidney biopsy were analyzed. The kidney biopsy was performed in our center by experienced nephrologists with 2 different methods, namely, NPS method and real-time ultrasound-guided needle (RTU) method. We compared rates of complications between 2 methods and evaluated univariate and multivariate association of risk factors with bleeding complications in the NPS group. <b><i>Results:</i></b> 626 kidney biopsies were performed between January 2016 and December 2016. There were 83.2% (521/626) participants in the NPS group and 16.8% (105/626) in the RTU group. There were more participants in the RTU group needing &gt;1 needle pass during biopsy than those in the NPS group (61.0 vs. 14.7%, <i>p</i> &lt; 0.001). Acute kidney disease (AKD) occurred before the procedure of kidney biopsy accounted for 13.8% (72/521) in the NPS group and 1.9% (2/105) in the RTU group. The renal pathological findings revealed higher number of glomeruli in the NPS group than in the RTU group (26.8 ± 13.0 vs. 17.2 ± 8.6, <i>p</i> &lt; 0.001). The incidence of bleeding complications in the NPS group was lower than that in the RTU group (9.2 vs. 21.9%, <i>p</i> &lt; 0.01). Logistic multivariate regression showed that AKD was independently associated with bleeding complications after kidney biopsy in the NPS group. <b><i>Conclusion:</i></b> Regarding the bleeding risk, there was noninferiority of NPS over RTU. AKD contributes to higher risks of bleeding complications after kidney biopsy.
DOI: 10.6084/m9.figshare.13141409.v1
title: Supplementary Material for: Acute Kidney Disease Increases the Risk of Post-Kidney Biopsy Bleeding Complications

description: <b><i>Introduction:</i></b> Kidney biopsy, providing the insightful information for most kidney diseases, is an invasive diagnostic tool with certain risks ranging from the least severe macroscopic hematuria to the most severe life-threatening bleeding necessitating renal artery embolization. We aimed to compare the postbiopsy bleeding complications between 2 common methods and to further explore the risk factors of bleeding complications in patients using the negative pressure suction puncture (NPS) method. <b><i>Methods:</i></b> We retrospectively collected the data from percutaneous native kidney biopsies in 2016. The clinical, laboratory tests, pathological findings, and the occurrence of bleeding complications following kidney biopsy were analyzed. The kidney biopsy was performed in our center by experienced nephrologists with 2 different methods, namely, NPS method and real-time ultrasound-guided needle (RTU) method. We compared rates of complications between 2 methods and evaluated univariate and multivariate association of risk factors with bleeding complications in the NPS group. <b><i>Results:</i></b> 626 kidney biopsies were performed between January 2016 and December 2016. There were 83.2% (521/626) participants in the NPS group and 16.8% (105/626) in the RTU group. There were more participants in the RTU group needing &gt;1 needle pass during biopsy than those in the NPS group (61.0 vs. 14.7%, <i>p</i> &lt; 0.001). Acute kidney disease (AKD) occurred before the procedure of kidney biopsy accounted for 13.8% (72/521) in the NPS group and 1.9% (2/105) in the RTU group. The renal pathological findings revealed higher number of glomeruli in the NPS group than in the RTU group (26.8 ± 13.0 vs. 17.2 ± 8.6, <i>p</i> &lt; 0.001). The incidence of bleeding complications in the NPS group was lower than that in the RTU group (9.2 vs. 21.9%, <i>p</i> &lt; 0.01). Logistic multivariate regression showed that AKD was independently associated with bleeding complications after kidney biopsy in the NPS group. <b><i>Conclusion:</i></b> Regarding the bleeding risk, there was noninferiority of NPS over RTU. AKD contributes to higher risks of bleeding complications after kidney biopsy.
DOI: 10.21227/fm11-c993
title: Optimal feature configuration for malware detection datasets

description: Datasets consiting of features extracted from API calls, network activity and Cuckoo signatures of 19994 public files of different types.
DOI: 10.5281/zenodo.4131650
title: Practice of antibiotics use and awareness of antimicrobial resistance among undergraduate medical students

description: Antibiotic resistance is one of the actual problems associated with the irrational use of antibiotics The aim of study is to investigate practice of antibiotics use and awareness of antimicrobial resistance among undergraduate medical students Siberian State Medical University (SSMU). Material and methods. A self-administered online questionnaire was used to assess the practice of antibiotic use and awareness of antimicrobial resistance among 5-6 year students of GP and pediatrician faculties of Siberian State Medical University. Results. 334 students took part in the survey. During the last year, 58.1% of respondents used antibacterial drugs. The leading reasons for the use of antibiotics were: angina - 47.3%, viral infection of upper airway- 24.4%, sinusitis and / or otitis - 20.2%, urinary tract infections - 18.3%, bronchitis - 11.5%, pneumonia - 8 %, acute intestinal infections - 5.7%. The most frequently used: amoxicillin / clavulanic acid -57.6%, amoxicillin - 29%, azithromycin - 19.4%, ciprofloxacin - 13.4%, cephalosporins of the 3rd generation - 8.1%, clarithromycin - 7.6%. Most of the students used antibiotics as prescribed by a doctor (58.8%) and adhered to the duration of treatment prescribed by the doctor. The vast majority of students (99.4%) are aware of the problem of antibiotic resistance and 95.8% consider this problem important for Russian medicine. Conclusions. Undergraduate students of the Siberian State Medical University demonstrated adherence to medical recommendations regarding the use of antibiotics and a high awareness of the problem of antibiotic resistance.
DOI: 10.21227/3v4y-n633
title: Optimal feature configuration for malware detection datasets

description: Datasets consiting of features extracted from API calls, network activity and Cuckoo signatures of 19994 public files of different types.
DOI: 10.6084/m9.figshare.13141406
title: Pharmacokinetic data of Esomeprazole in critically ill patients

description: A data set on critically ill patients received once intravenous (IV) esomeprazole 40 mg, which information recorded included demographic data, laboratory values, CYP2C19 Metabolic Phenotype, stress ulcer risk factor, plasma concentration of esomeprazole at each sampling point and PK parameters. <br>
DOI: 10.6084/m9.figshare.13141406.v2
title: Pharmacokinetic data of Esomeprazole in critically ill patients

description: A data set on critically ill patients received once intravenous (IV) esomeprazole 40 mg, which information recorded included demographic data, laboratory values, CYP2C19 Metabolic Phenotype, stress ulcer risk factor, plasma concentration of esomeprazole at each sampling point and PK parameters. <br>
DOI: 10.6084/m9.figshare.13141406.v1
title: Pharmacokinetic data of Esomeprazole in critically ill patients

description: A data set on critically ill patients received once intravenous (IV) esomeprazole 40 mg, which information recorded included demographic data, laboratory values, CYP2C19 Metabolic Phenotype, stress ulcer risk factor, plasma concentration of esomeprazole at each sampling point and PK parameters. <br>
DOI: 10.6084/m9.figshare.7533062.v2
title: Synthesis and Biological Evaluation of Some New Thiophene, Thiazole, Dithiolane Derivatives and Related Compounds

description: A series of novel of heterocycles containing thiazole, thiophene moieties, and dithiolane derivatives were designed, synthesized, and characterized by <sup>1</sup>H NMR, IR, elemental analysis, and mass spectra using 2-cyanoacetylpyrrole <b>1</b> as a starting material. Under Gewald reaction condition thiazole derivative <b>3</b> was obtained while, reaction of thiocarbamoyl salt <b>6</b> with α-haloketone yielded the corresponding new synthesized derivatives <b>8</b>–<b>11</b>. When <b>1</b> was treated with cyclohydrocarbon keton in the presence of sulfur gave the corresponding aminothiophene and aminobenzothiophene derivatives <b>4</b> and <b>5</b>, respectively. Dithiolanone <b>16</b> was obtained by reaction of <b>12</b> with chloroacetyl chloride. The newly synthesized compounds were examined for their antioxidant and anticancer activities. Some of the newly synthesized compounds were found to be equipotent or more potent than drug reference as shown in the results. Moreover, molecular modeling was appreciated and was consistent with the experimental antioxidant activity results.
DOI: 10.6084/m9.figshare.7533062
title: Synthesis and Biological Evaluation of Some New Thiophene, Thiazole, Dithiolane Derivatives and Related Compounds

description: A series of novel of heterocycles containing thiazole, thiophene moieties, and dithiolane derivatives were designed, synthesized, and characterized by <sup>1</sup>H NMR, IR, elemental analysis, and mass spectra using 2-cyanoacetylpyrrole <b>1</b> as a starting material. Under Gewald reaction condition thiazole derivative <b>3</b> was obtained while, reaction of thiocarbamoyl salt <b>6</b> with α-haloketone yielded the corresponding new synthesized derivatives <b>8</b>–<b>11</b>. When <b>1</b> was treated with cyclohydrocarbon keton in the presence of sulfur gave the corresponding aminothiophene and aminobenzothiophene derivatives <b>4</b> and <b>5</b>, respectively. Dithiolanone <b>16</b> was obtained by reaction of <b>12</b> with chloroacetyl chloride. The newly synthesized compounds were examined for their antioxidant and anticancer activities. Some of the newly synthesized compounds were found to be equipotent or more potent than drug reference as shown in the results. Moreover, molecular modeling was appreciated and was consistent with the experimental antioxidant activity results.
DOI: 10.5281/zenodo.4126975
title: Implicit aspect-based opinion mining and analysis of airline industry based on user generated reviews

description: Mining opinions from reviews has been a field of ever-growing research. These include mining opinions on document level, sentence-level, and even aspect level of a review. While explicitly mentioned aspects in a review have been widely researched, very little work has been done in gathering opinions on aspects that are <em><strong>implied </strong></em>and not explicitly mentioned. E.g. “<strong><em>the flight was spacious and there was plenty of legroom</em></strong>”. This gives an opinion on the <em><strong>entities </strong></em>of the <em><strong>cabin </strong></em>and <em><strong>seat </strong></em>of an airline. Words like “<strong><em>spacious</em></strong>” and phrases like “<strong><em>plenty of legroom</em></strong>” help identify these <em><strong>implied entities</strong></em> and the <strong><em>opinions </em></strong>attached to them. Not much research has been done for gathering such implicit aspects and opinions for airline reviews. The present dataset is a <em><strong>manually annotated domain-specific aspect-based corpus </strong></em>that helps a study to extract and analyze opinions about such implied aspects and entities of airlines.
DOI: 10.5281/zenodo.4126974
title: Implicit aspect-based opinion mining and analysis of airline industry based on user generated reviews

description: Mining opinions from reviews has been a field of ever-growing research. These include mining opinions on document level, sentence-level, and even aspect level of a review. While explicitly mentioned aspects in a review have been widely researched, very little work has been done in gathering opinions on aspects that are <em><strong>implied </strong></em>and not explicitly mentioned. E.g. “<strong><em>the flight was spacious and there was plenty of legroom</em></strong>”. This gives an opinion on the <em><strong>entities </strong></em>of the <em><strong>cabin </strong></em>and <em><strong>seat </strong></em>of an airline. Words like “<strong><em>spacious</em></strong>” and phrases like “<strong><em>plenty of legroom</em></strong>” help identify these <em><strong>implied entities</strong></em> and the <strong><em>opinions </em></strong>attached to them. Not much research has been done for gathering such implicit aspects and opinions for airline reviews. The present dataset is a <em><strong>manually annotated domain-specific aspect-based corpus </strong></em>that helps a study to extract and analyze opinions about such implied aspects and entities of airlines.
DOI: 10.6084/m9.figshare.13139423.v1
title: Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in recovered COVID-19 individuals

description: <b>Coronavirus Disease 2019 (COVID-19), an emerging disease caused by infection with SARS-CoV-2</b><b><sup>1-3</sup></b><b>, </b><b>has spread worldwide and caused 21.2 million infections and 0.76 million deaths (as of August 15, 2020</b><b>)</b><b><sup>4</sup></b><b>.</b><b> </b><b>Symptoms of COVID-19 are varied and can be asymptomatic, mild, moderate, and severe</b><b><sup>5,6</sup></b><b>. In the early phase of SARS-CoV-2 infection, T and B cell counts are dramatically decreased</b><b><sup>7,8</sup></b><b>; however, IgM</b><b><sup>9-12</sup></b><b> and IgG</b><b><sup>13-15</sup></b><b> are detectable within 14 days after symptom onset. In COVID-19 convalescents, spike-specific neutralizing antibodies (nAbs) are variable</b><b><sup>3,16,17</sup></b><b>. To date, no specific drug or vaccine is available for COVID-19. Clinical trials have shown that patients benefit from the treatments with convalescent serum</b><b><sup>18,19</sup></b><b>. Nevertheless, antibody responses and cross-reactivity with other coronaviruses in the COVID-19 convalescents are largely unknown. Here we show that the majority of COVID-19 convalescents maintained SARS-CoV-2 spike S1- and S2-specific antibodies with neutralizing activity against the SARS-CoV-2 pseudotyped virus and that some of the antibodies cross-neutralized SARS-CoV, MERS-CoV, or both pseudotyped viruses. Convalescents who experienced severe COVID-19 disease showed higher nAb titers, a faster increase of lymphocyte counts, and a higher frequency of CXCR3<sup>+</sup> T follicular help (Tfh) cells than did non-severe convalescents. Circulating Tfh cells were spike-specific and functional, and the frequencies of CXCR3<sup>+</sup> Tfh cells were positively associated with nAb titers in recovered COVID-19 individuals. </b><b>No subjects had </b><b>detectable autoantibodies</b><b>. These findings provide insights into nAb responses in COVID-19 convalescents and facilitate the treatment and vaccine development for SARS-CoV-2 infection.</b>
DOI: 10.6084/m9.figshare.13141445.v1
title: Additional file 1 of Combined Transcriptome and Metabolome analysis of Pitaya fruit unveiled the mechanisms underlying Peel and pulp color formation

description: Additional file 1 : Table S1. List of primers used for qRT-PCR analysis. Table S2. List of DEGs between RR and GW-peel. Table S3. List of DEGs between RR and YW-peel. Table S4. List of DEGs between YW and GW-peel. Table S5. List of DEGs between RR and GW-pulp. Table S6. List of DEGs between RR and YW-pulp. Table S7. List of DEGs between YW and GW-pulp. Table S8. Summary of transcription factors differentially regulated between different fruit peels and pulps. Table S9. Concentrations of differentially accumulated metabolites between different peel and pulp colors
DOI: 10.6084/m9.figshare.13141447
title: Additional file 1 of Reliability and minimal detectable change of the ‘Imperial Spine’ marker set for the evaluation of spinal and lower limb kinematics in adults

description: Additional file 1: Table S1. Positioning of the ‘Imperial Spine’ marker set.
DOI: 10.6084/m9.figshare.13141466
title: Additional file 2 of Testing allometric scaling relationships in plant roots

description: Additional file 2.
DOI: 10.6084/m9.figshare.13141462
title: Additional file 1 of Phenylpropanoid metabolism and pigmentation show divergent patterns between brown color and green color cottons as revealed by metabolic and gene expression analyses

description: Additional file 1: Table S1. Information on prey sequences used for BLAST analysis. Table S2. Primers used in this study. Table S3. Formula of standard samples for total flavonoid content measurement. Table S4. FPKM of lignin and lignan biosynthesis genes in cotton fibers.
DOI: 10.13140/rg.2.2.11088.94726
title: Fig. 2 20 Pulse charge-discharge voltage traction results (d) Pulse charge voltage traction error
DOI: 10.5517/ccdc.csd.cc24423h
title: CCDC 1970115: Experimental Crystal Structure Determination

description: Related Article: Upasana Banerjee, Sujan K. Sarkar, Jeanette A. Krause, William L. Karney, Manabu Abe, Anna D. Gudmundsdottir|2020|Org.Lett.|22|7885|doi:10.1021/acs.orglett.0c02794
DOI: 10.6084/m9.figshare.13141462.v1
title: Additional file 1 of Phenylpropanoid metabolism and pigmentation show divergent patterns between brown color and green color cottons as revealed by metabolic and gene expression analyses

description: Additional file 1: Table S1. Information on prey sequences used for BLAST analysis. Table S2. Primers used in this study. Table S3. Formula of standard samples for total flavonoid content measurement. Table S4. FPKM of lignin and lignan biosynthesis genes in cotton fibers.
DOI: 10.6084/m9.figshare.13141466.v1
title: Additional file 2 of Testing allometric scaling relationships in plant roots

description: Additional file 2.
DOI: 10.13140/rg.2.2.24510.72005
title: Fig. 2 20 Pulse charge-discharge voltage traction results (d) Pulse charge voltage traction error
DOI: 10.6084/m9.figshare.13141471.v1
title: Additional file 2 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 2 Table S2. Significant sugar beet DEGs related to cell wall architecture, metabolism, developmental process, transport, defense response, hormone metabolism and transcription factors in the compatible sugar beet- BCN interaction.
DOI: 10.6084/m9.figshare.13141468.v1
title: Additional file 1 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 1 Table S1. Significant differentially expressed genes (DEGs) of sugar beet in the compatible sugar beet-beet cyst nematode (BCN) interaction.
DOI: 10.6084/m9.figshare.13141471
title: Additional file 2 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 2 Table S2. Significant sugar beet DEGs related to cell wall architecture, metabolism, developmental process, transport, defense response, hormone metabolism and transcription factors in the compatible sugar beet- BCN interaction.
DOI: 10.6084/m9.figshare.13141477
title: Additional file 4 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 4 Table S4. Significant differentially expressed sugar beet genes related to cell wall architecture, transport, defense response, hormone metabolism and transcription factors in the incompatible sugar beet- BCN interaction.
DOI: 10.6084/m9.figshare.13141474
title: Additional file 3 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 3 Table S3. Significant sugar beet DEGs in the incompatible sugar beet- BCN interaction.
DOI: 10.6084/m9.figshare.13141468
title: Additional file 1 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 1 Table S1. Significant differentially expressed genes (DEGs) of sugar beet in the compatible sugar beet-beet cyst nematode (BCN) interaction.
DOI: 10.6084/m9.figshare.13141477.v1
title: Additional file 4 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 4 Table S4. Significant differentially expressed sugar beet genes related to cell wall architecture, transport, defense response, hormone metabolism and transcription factors in the incompatible sugar beet- BCN interaction.
DOI: 10.6084/m9.figshare.13141480.v1
title: Additional file 5 of Molecular insights into the compatible and incompatible interactions between sugar beet and the beet cyst nematode

description: Additional file 5 Table S5. Significant DEGs in comparison of resistant and susceptible sugar beet cultivars in uninfected and BCN-infected conditions.