cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17876/plate/dr.3/plates/110_69940
title: Digital object identifier (DOI) for the plate 69940 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69941
title: Digital object identifier (DOI) for the plate 69941 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69942
title: Digital object identifier (DOI) for the plate 69942 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69943
title: Digital object identifier (DOI) for the plate 69943 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69944
title: Digital object identifier (DOI) for the plate 69944 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69945
title: Digital object identifier (DOI) for the plate 69945 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69946
title: Digital object identifier (DOI) for the plate 69946 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69947
title: Digital object identifier (DOI) for the plate 69947 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69948
title: Digital object identifier (DOI) for the plate 69948 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69949
title: Digital object identifier (DOI) for the plate 69949 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69950
title: Digital object identifier (DOI) for the plate 69950 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69951
title: Digital object identifier (DOI) for the plate 69951 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69952
title: Digital object identifier (DOI) for the plate 69952 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69953
title: Digital object identifier (DOI) for the plate 69953 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69954
title: Digital object identifier (DOI) for the plate 69954 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69955
title: Digital object identifier (DOI) for the plate 69955 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69956
title: Digital object identifier (DOI) for the plate 69956 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69957
title: Digital object identifier (DOI) for the plate 69957 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69958
title: Digital object identifier (DOI) for the plate 69958 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69959
title: Digital object identifier (DOI) for the plate 69959 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69960
title: Digital object identifier (DOI) for the plate 69960 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69961
title: Digital object identifier (DOI) for the plate 69961 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69962
title: Digital object identifier (DOI) for the plate 69962 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69963
title: Digital object identifier (DOI) for the plate 69963 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69964
title: Digital object identifier (DOI) for the plate 69964 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69965
title: Digital object identifier (DOI) for the plate 69965 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69966
title: Digital object identifier (DOI) for the plate 69966 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69967
title: Digital object identifier (DOI) for the plate 69967 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69968
title: Digital object identifier (DOI) for the plate 69968 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69969
title: Digital object identifier (DOI) for the plate 69969 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69970
title: Digital object identifier (DOI) for the plate 69970 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69971
title: Digital object identifier (DOI) for the plate 69971 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69972
title: Digital object identifier (DOI) for the plate 69972 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69973
title: Digital object identifier (DOI) for the plate 69973 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69974
title: Digital object identifier (DOI) for the plate 69974 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69975
title: Digital object identifier (DOI) for the plate 69975 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69976
title: Digital object identifier (DOI) for the plate 69976 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69977
title: Digital object identifier (DOI) for the plate 69977 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69978
title: Digital object identifier (DOI) for the plate 69978 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69979
title: Digital object identifier (DOI) for the plate 69979 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69980
title: Digital object identifier (DOI) for the plate 69980 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69981
title: Digital object identifier (DOI) for the plate 69981 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69982
title: Digital object identifier (DOI) for the plate 69982 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69983
title: Digital object identifier (DOI) for the plate 69983 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69984
title: Digital object identifier (DOI) for the plate 69984 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69985
title: Digital object identifier (DOI) for the plate 69985 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69986
title: Digital object identifier (DOI) for the plate 69986 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69987
title: Digital object identifier (DOI) for the plate 69987 in archive 110 from the APPLAUSE DR3
DOI: 10.17876/plate/dr.3/plates/110_69988
title: Digital object identifier (DOI) for the plate 69988 in archive 110 from the APPLAUSE DR3
DOI: 10.7910/dvn/5og9vv/oagby6
title: beps9297_replication.tab

description: :unav
DOI: 10.7910/dvn/5og9vv/wvlmi1
title: dist.tab

description: :unav
DOI: 10.14469/hpc/6075
title: C18 CCSD/6-311G(d) SCF=11 Kekule mode = -4310 cm-1

description: Gaussian Calculation
DOI: 10.5281/zenodo.3382983
title: MoMA Collection - Automatic Monthly Update

description: Temporary Description
DOI: 10.5281/zenodo.3382984
title: MoMA Collection - Automatic Monthly Update

description: Temporary Description
DOI: 10.5061/dryad.8g3rv46/1
title: Dryad Item 10.5061/DRYAD.8G3RV46/1

description: (:tba)
DOI: 10.5281/zenodo.3382295
title: Compartment and Hub Definitions Tune Metabolic Networks for Metabolomic Interpretations

description: This archive contains data for a report by the same title.<br> Data relate to software projects MetaboNet and DyMetaboNet.<br> MetaboNet: https://github.com/tcameronwaller/metabonet<br> DyMetaboNet: https://github.com/tcameronwaller/dymetabonet File descriptions dymetabonet_2019-08-29.mp4 ... raw screen capture video of DyMetaboNet<br> dock_metabonet_2019-08-18.zip ... complete MetaboNet export<br> model_* ... curation of human metabolic model by MetaboNet<br> model_dymetabonet.zip ... format for DyMetaboNet<br> model_compartments* ... compartments<br> model_processes* ... processes<br> model_reactions* ... reactions<br> model_metabolites* ... metabolites<br> measurement_* ... curation of metabolomic measurements by MetaboNet<br> measurement_study_*_report.tsv ... summary of match measurements to metabolites<br> measurement_study_*.tsv ... metabolites' fold changes and probabilities between groups<br> measurement_study_*_metaboanalyst.txt ... format for MetaboAnalyst<br> measurement_study_*_metaboanalyst_pair.txt ... format for MetaboAnalyst with sample pairs<br> network_* ... multiple definitions of metabolic networks<br> network_compartments-true_hubs-true.zip ... compartmental network with hubs<br> network_compartments-true_hubs-false.zip ... compartmental network without hubs<br> network_compartments-false_hubs-true.zip ... noncompartmental network with hubs<br> network_compartments-false_hubs-false.zip ... noncompartmental network without hubs<br> network_compartments-*_hubs_*/network_cytoscape.json ... format for Cytoscape<br> network_compartments-*_hubs_*/network_networkx.pickle ... format for NetworkX<br> network_compartments-*_hubs_*/nodes_reactions.pickle ... network's nodes for reactions<br> network_compartments-*_hubs_*/nodes_metabolites.pickle ... network's nodes for metabolites<br> network_compartments-*_hubs_*/links.pickle ... network's links<br> network_compartments-*_hubs_*/analysis/nodes_reactions.tsv ... nodes' metrics relative to reactions<br> network_compartments-*_hubs_*/analysis/nodes_metabolites.tsv ... nodes' metrics relative to metabolites<br> network_compartments-*_hubs_*/analysis/network_reactions.tsv ... network's metrics relative to reactions<br> network_compartments-*_hubs_*/analysis/network_metabolites.tsv ... network's metrics relative to metabolites<br> network_compartments-*_hubs_*/measurement/metabolites.tsv ... measurements on nodes for metabolites
DOI: 10.6073/pasta/f5443b4f2c945d0701abaf793cbf8d7f
title: PIE LTER Year 2016, 15 minute measurements of dissolved oxygen, water temperature at the Ipswich River head of tide, Sylvania Dam in Ipswich, MA.

description: Year 2016, continuous measurements, every 15 minutes, were made of dissolved oxygen, water temperature in the Ipswich River behind the head of tide dam in Ipswich, MA.
DOI: 10.15468/12myso
title: Two new species of groundwater amphipods of the genus Niphargus Schiödte, 1849 from northwestern Iran

description: This dataset contains the digitized treatments in Plazi based on the original journal article Mamaghani-Shishvan, Mahmoud, Esmaeili-Rineh, Somayeh (2019): Two new species of groundwater amphipods of the genus Niphargus Schiödte, 1849 from northwestern Iran. European Journal of Taxonomy 546: 1-23, DOI: https://doi.org/10.5852/ejt.2019.546
DOI: 10.5061/dryad.2264mf4/1
title: Dryad Item 10.5061/DRYAD.2264MF4/1

description: (:tba)
DOI: 10.17632/8h3jzf2t78.1
title: Data for: Plasma diamine oxidase activity decline with diarrhea severity in calves indicating systemic dysfunction related to intestinal mucosal damage

description: A total of 50 Holstein calves were enrolled. Thirty-six of the 50 calves presented diarrhea and were sub-classified by severity based on fecal status (0: firm, 1: pasty, 2: loose, and 3: watery) and blood pH (acidemia: blood pH &lt;7.25) as follows: Seventeen calves exhibiting watery diarrhea and/or fall into acidemia were sub-categorized into the severe group. The other nineteen calves exhibiting pasty or loose diarrhea and not fall into acidemia were sub-categorized into the moderate group. The remaining 14 calves without diarrhea were assigned to the control group.
DOI: 10.5519/qd.zwy54vun
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.7910/dvn/edqldk/16ytvb
title: FR, BSV 03 VI, 2.5 x, PPL 2.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/79rzoe
title: FR, BSV 03 II, 2.5 x, PPL-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/pmruur
title: FR, BSV 03 VI, 2.5 x, XP.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/vm3ywj
title: FR, BSV 03 VII, 2.5 x, XP.jpg

description: :unav
DOI: 10.7910/dvn/gtfaqw/2e8skb
title: pedro-fonseca-ad-ufpe-2019.tab

description: :unav
DOI: 10.7910/dvn/gtfaqw/vihyyg
title: pedro-fonseca-ad-ufpe-2019.R

description: :unav
DOI: 10.7910/dvn/edqldk/4304sh
title: Geo_sample 005.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/674y9x
title: FR, BSV 03 V, 2.5 x, PPL.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/9qer9g
title: FR, BSV 03 I, 2.5 x, XP-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/djl9iy
title: FR 6_slip_SEM.tif

description: :unav
DOI: 10.7910/dvn/edqldk/k0etll
title: FR, BSV 03 I, 10 x, PPL volcanic rock.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/kekser
title: FR, BSV 03 I, 2.5 x, PPL-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/kylnsc
title: FR, BSV 03 V, 5 x, XP.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/pq43xs
title: FR1_Theta_2-Theta_XRD.raw

description: :unav
DOI: 10.7910/dvn/edqldk/q8fhwm
title: FR, BSV 03 VIII, 2.5 x, PPL.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/vchnz1
title: FR, BSV 03 III, 2.5 x, XP-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/6dkqa7
title: Concotti Forcello p-XRF final table-1.tab

description: :unav
DOI: 10.7910/dvn/edqldk/8rxpci
title: FR6_slip_Theta_2-Theta_XRD.raw

description: :unav
DOI: 10.7910/dvn/edqldk/mwzjo5
title: Geo_sample_ 006.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/qnq7n5
title: FR, BSV 03 I, 5 x, PPL calcite-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/qtvkmg
title: FR4_Theta_2-Theta_XRD.raw

description: :unav
DOI: 10.7910/dvn/edqldk/tcoxm6
title: FR, BSV 03 VII, 2.5 x, PPL.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/xpslkz
title: FR 6_SEM.tif

description: :unav
DOI: 10.7910/dvn/edqldk/1dptuv
title: FR 8_SEM.tif

description: :unav
DOI: 10.7910/dvn/edqldk/8wtg00
title: FR, BSV 03 V, 2.5 x, XP 2.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/e9lcja
title: FR, BSV 03 IV, 2.5 x, XP.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/fhwkgv
title: FR 5_SEM.tif

description: :unav
DOI: 10.7910/dvn/edqldk/ft1ix1
title: FR, BSV 03 V, 2.5 x, XP.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/i5wyqo
title: FR, BSV 03 VI, 2.5 x, XP 2.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/l7rx1x
title: FR, BSV 03 VIII, 2.5 x, XP.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/rmr6e7
title: FR8_Theta_2-Theta_XRD.raw

description: :unav
DOI: 10.7910/dvn/edqldk/witzhu
title: FR6_Theta_2-Theta_XRD.raw

description: :unav
DOI: 10.7910/dvn/edqldk/5ilzph
title: FR, BSV 03 IV, 2.5 x, PPL-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/cmic68
title: FR, BSV 03 I, 10 x, XP volcanic rock.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/dxjlsk
title: Concotti Forcello p-XRF raw data-1.tab

description: :unav
DOI: 10.7910/dvn/edqldk/ixycus
title: FR, BSV 03 VI, 2.5 x, PPL.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/lqrfup
title: FR, BSV 03 II, 2.5 x, XP-1.jpg

description: :unav
DOI: 10.7910/dvn/edqldk/p02sm4
title: FR 4_SEM.tif

description: :unav
DOI: 10.7910/dvn/edqldk/qypu3u
title: FR 2_SEM.tif

description: :unav
DOI: 10.7910/dvn/edqldk/zgd6e0
title: FR, BSV 03 III, 2.5 x, PPL-1.jpg

description: :unav
DOI: 10.14469/hpc/6076
title: C14 B3LYP/6-31G(d) Kekule mode = 1115 cm-1

description: Gaussian Calculation
DOI: 10.5281/zenodo.3382312
title: Lume's journal articles XML files

description: XML files from Lume's journal article community extracted from PDFs with GROBID https://lume.ufrgs.br/handle/10183/19209
DOI: 10.5281/zenodo.3382313
title: Lume's journal articles XML files

description: XML files from Lume's journal article community extracted from PDFs with GROBID https://lume.ufrgs.br/handle/10183/19209
DOI: 10.7910/dvn/vs5jdp/8k6ogm
title: PR_LC2010.zip

description: The LCLU data of 2010 at spatial resolution of 30 meters in the GeoTiff data format.
DOI: 10.7910/dvn/vs5jdp/olldgc
title: PR_LC2000.zip

description: The LCLU data of 2000 at spatial resolution of 30 meters in the GeoTiff data format.
DOI: 10.6073/pasta/7c69b449417a936f005758d1a183c303
title: PIE LTER Year 2018, 15 minute measurements of dissolved oxygen, water temperature at the Ipswich River head of tide, Sylvania Dam in Ipswich, MA.

description: Year 2018, continuous measurements, every 15 minutes, were made of dissolved oxygen, water temperature in the Ipswich River behind the head of tide dam in Ipswich, MA.
DOI: 10.6073/pasta/8f1b2522788c6b1e6bc43605e4a61c50
title: PIE LTER Year 2017, 15 minute measurements of dissolved oxygen, water temperature at the Ipswich River head of tide, Sylvania Dam in Ipswich, MA.

description: Year 2017, continuous measurements, every 15 minutes, were made of dissolved oxygen, water temperature in the Ipswich River behind the head of tide dam in Ipswich, MA.
DOI: 10.14469/hpc/6074
title: C14 MP2/Def2-TZVPP, kekule vibration = 6481 cm-1

description: Gaussian Calculation
DOI: 10.5519/qd.fsvgwwmy
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (786 records)
DOI: 10.7910/dvn/6xs8z1/bnhuco
title: small-appendix.pdf

description: appendix to paper
DOI: 10.7910/dvn/6xs8z1/dwiwo0
title: ge.tab

description: George and Epstein data, included here for convenience
DOI: 10.7910/dvn/6xs8z1/jt2w0l
title: project-directory.zip

description: the project directory to reproduce all of our results, also at https://github.com/kellymccaskey/small
DOI: 10.7910/dvn/6xs8z1/smodb2
title: README.md

description: :unav
DOI: 10.7910/dvn/6xs8z1/tvlzxu
title: weisiger.tab

description: Weisiger data, included here for convenience
DOI: 10.7910/dvn/6xs8z1/ybpaq1
title: small.pdf

description: main manuscript
DOI: 10.17632/2ftkfv8gdd.1
title: Data for: The timing of Malvales evolution: incorporating its extensive fossil record to inform about lineage diversification
DOI: 10.17632/gty4zkxd4f.1
title: Data for: Does Specialized Psychological Treatment for Offending Reduce Recidivism? A Meta-Analysis Examining Staff and Program Variables as Predictors of Treatment Effectiveness

description: SPSS file containing all articles reviewed for the meta-analyses and key study variables.
DOI: 10.17632/phpftf6bb3.1
title: Data for: The timing of Malvales evolution: incorporating its extensive fossil record to inform about lineage diversification

description: Molecular sequence alignment and taxon sets for extant species and fossils
DOI: 10.17632/xnspbzxk26.1
title: Data for: Wettability Alteration Induced Water Uptake in Shale Oil Reservoirs: A Geochemical Interpretation for Oil-Brine-OM Interaction during Hydraulic Fracturing
DOI: 10.5519/qd.ucy8gwn3
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1269 records)
DOI: 10.17632/89h2s5vwrj.1
title: Data for: The long-term impacts of climate and fire on catchment processes and aquatic ecosystem response in Tasmania, Australia
DOI: 10.17632/phpftf6bb3.2
title: Data for: The timing of Malvales evolution: incorporating its extensive fossil record to inform about lineage diversification

description: Molecular sequence alignment and taxon sets for extant species and fossils
DOI: 10.5281/zenodo.3382816
title: Publication analysis on gliomas

description: Supplementary material 1: Original data of Gliomas publication Supplementary material 2: Python code for analysis.
DOI: 10.5281/zenodo.3382817
title: Publication analysis on gliomas

description: Supplementary material 1: Original data of Gliomas publication Supplementary material 2: Python code for analysis.
DOI: 10.25345/c5mh21
title: MassIVE MSV000084262 - Glycoproteomics in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN) disease
title: Glycoproteomic analysis of T cell blasts from 3 healthy controls and 3 XMEN patients.
DOI: 10.5281/zenodo.3382318
title: Preliminary investigation of caspase6 cleavage of HTT and HTT-HAP40 2019/07/15

description: <strong>Project: </strong>Structural and functional analysis of huntingtin protein <strong>Experiment: </strong>Preliminary investigation of caspase6 cleavage of HTT and HTT-HAP40 <strong>Date: </strong>2019/07/15 <strong>Background: </strong>HTT is cleaved by numerous enzymes to generate protein fragments, many of which have implications for disease pathogenesis (reviewed by Saudou et al (2016) Neuron). However, very few of these proteases have been assessed for their cleavage of purified HTT protein or HTT-HAP40 protein samples. Caspase-6 cleavage of HTT has been reported to generate a aa. 1-586 fragment. However, it is not clear how HAP40 binding of HTT might affect cleavage by caspase-6 or release of this fragment from the complex structure. The caspase-6 cleavage site is in the intrinsically disordered region, distal from the globular structure. How cleavage might release a 1-586 fragment from the remainder of the structure remains incompletely understood. <strong>Rationale: </strong>In this experiments I am aiming to optimise conditions for caspase-6 cleavage to test how proteolytic cleavage of HTT affects “pathogenic” fragment formation for apo vs HAP40-bound HTT.
description: Dr. Harding is the recipient of the Huntington's Disease Society of America Berman Topper Career Development Fellowship which funds and supports this research, in addition to generous funding from the CHDI Foundation and the Huntington Society of Canada. The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
DOI: 10.5281/zenodo.3382319
title: Preliminary investigation of caspase6 cleavage of HTT and HTT-HAP40 2019/07/15

description: <strong>Project: </strong>Structural and functional analysis of huntingtin protein <strong>Experiment: </strong>Preliminary investigation of caspase6 cleavage of HTT and HTT-HAP40 <strong>Date: </strong>2019/07/15 <strong>Background: </strong>HTT is cleaved by numerous enzymes to generate protein fragments, many of which have implications for disease pathogenesis (reviewed by Saudou et al (2016) Neuron). However, very few of these proteases have been assessed for their cleavage of purified HTT protein or HTT-HAP40 protein samples. Caspase-6 cleavage of HTT has been reported to generate a aa. 1-586 fragment. However, it is not clear how HAP40 binding of HTT might affect cleavage by caspase-6 or release of this fragment from the complex structure. The caspase-6 cleavage site is in the intrinsically disordered region, distal from the globular structure. How cleavage might release a 1-586 fragment from the remainder of the structure remains incompletely understood. <strong>Rationale: </strong>In this experiments I am aiming to optimise conditions for caspase-6 cleavage to test how proteolytic cleavage of HTT affects “pathogenic” fragment formation for apo vs HAP40-bound HTT.
description: Dr. Harding is the recipient of the Huntington's Disease Society of America Berman Topper Career Development Fellowship which funds and supports this research, in addition to generous funding from the CHDI Foundation and the Huntington Society of Canada. The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
DOI: 10.5061/dryad.tr87dh0/1
title: Dryad Item 10.5061/DRYAD.TR87DH0/1

description: (:tba)