cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.18712/nsd-nsd2328-v1
title: Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015

description: The Scandinavian countries have the highest prevalence of type 1 diabetes in the world with a steady increase in Norway of 600 new cases yearly. Type 1 diabetes mellitus (T1DM) is an autoimmune insulin deficiency due to destruction of insulin producing beta-cells. It is the most common type of diabetes in children and is induced by various environmental factors acting on a genetic predisposition. There is a parallel occurrence of increased diabetes prevalence and a high exposure burden of endocrine disruptors (EDs), leaking from consumer products, over the last decades. Continuous presence of these chemicals in urine from adults, children and even infants reflects a constant exposure to EDs. The aim of the project was to investigate the effect of EDs on the development of T1DM. We investigated the effect of combined exposure to some of the most commonly found EDs, bisphenol A, di(2-ethylhexyl) phthalate (DEHP), diisobuthyl phthalate (DIBP), dibuthyl phthalate (DBP) and benzyl buthyl phthalate (BBP), in a mouse model for T1DM. Non obese diabetic (NOD) mice spontaneously develop T1DM and we monitored if the selected endocrine disruptors had an impact on the time of onset and incidence of the disease. To enable fetal and early life exposure we exposed pregnant and lactating mice. Progression of T1DM in pups was monitored through measurements of blood glucose, autoantibodies, proinflammatory cytokines and immuno-phenotyping of peripheral lymph nodes. The degree of insulitis in the pancreas and the amount of apoptotic beta cells was evaluated. Furthermore, the mechanisms involved in beta-cell death were investigated ex vivo in pancreatic islets and in a beta cell-line in vitro. The knowledge gained in this project will help to improve toxicological evaluations and health hazard assessment of EDs since there is limited knowledge on immunological effects of transmaternal exposure to a combination of these chemicals.
DOI: 10.6084/m9.figshare.22133897.v1
title: Supplementary Material for: Two very rare cases of metastatic thymic carcinoma with Sjogren’s syndrome: A Case series

description: Thymic tumors are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to be associated with autoimmune disorders or paraneoplastic syndromes. When these phenomena do occur, the vast majority are myasthenia gravis, pure red cell aplasia or systemic lupus erythematous (SLE). Paraneoplastic Sjogren’s syndrome is a rare complication of thymic carcinoma, with only two cases previously reported. Here we present two cases of patients with metastatic thymic carcinoma who developed autoimmune phenomena consistent with Sjogren’s syndrome without classical symptoms prior to treatment. One patient opted for surveillance of their malignancy while the other underwent chemoimmunotherapy with favourable results. These case reports describe two distinctive clinical presentations of a rare paraneoplastic phenomenon.
DOI: 10.18712/nsd-nsd2329-v2
title: Medicines and Patient Safety: Elderly and Other Vulnerable Patients, 2015

description: The main objectives of this project were to make the use of medicines safer and more effective for vulnerable patients, improving the health of patients through health services research focusing on the use of medicines by individuals and by society, to utilize pharmacoeconomic methodology in regard to prescribing quality and pharmaceutical intervention, and to analyze how this affects patient safety. The study of medicines and safety in vulnerable patients groups has many application potentials. By improving prescribing quality and through pharmacoeconomic assessments, efforts may reduce the risk of medication errors and promote a more rational use of the governmental health budget. This project includes a research strategy to be conducted by a research group in social pharmacy and pharmacy practice in collaboration with several research institutions on the Western Health Region of Norway, at the University of Oslo and the University of Groeningen. The research project was built on two substudies (elderly, herbal medicines), with medicines and patient safety as the common denominator. 

The data material includes following datasets:
- Mamen et al.: The aim of this study was to investigate Norwegian elderly patients' need for drug information and their attitudes towards MURs. Method: Structured questionnaire. In Norway's two largest cities, 162 patients who used at least one prescription drug were recruited from 18 senior centres. 
- Heitmann, Solheimsnes et al.: The purposes of this study were to investigate the treatments used for nausea and vomiting of pregnancy (NVP) according to NVP severity among Norwegian women and to assess whether maternal characteristics and attitudes were related to the use of pharmacological treatment of NVP. Method: Cross-sectional web-based study accessible from November 10th, 2014 to January 31st, 2015. Pregnant women and mothers with children =1 year of age were eligible to participate. 
- Heitmann, Svendsen, et al.: The aim of this study was to explore thoughts and attitudes among Norwegian pregnant women and GPs on treatment of NVP and pregnancy care. Method: Separate focus-group discussions were conducted with pregnant women and GPs. 
- Andreassen et al.: The aim of this study was to explore the perspectives of physicians, registered nurses and auxiliary nurses on the use, usefulness and potential challenges of using capillary blood glucose measurements in nursing homes, and the procedures for doing so. Method: three profession-specific focus group interviews. Interviews were transcribed in modified verbatim form and analysed in accordance with Malterud's principles of systematic text condensation. Five physicians, four registered nurses and three auxiliary nurses participated in the focus groups.

For further information about ”Medicines and Patient Safety: Elderly and Other Vulnerable Patients, 2015”, please contact the principal investigator.
DOI: 10.18712/nsd-nsd2330-v1
title: Screen Tablets and Language Stimulation in Kindergartens: Developing Tools to Assess the Effect of Tablet Screens on Linguistic Development, 2015

description: Kindergartens experience increasing expectations to introduce digital technology, and are increasingly making use of digital technologies in different activities. The kindergartens are crucial arenas for children's language development. Children learn languages first and foremost by using language in social situations, and through direct engagement in different language activities. Especially important are the ways that adults encourage children to take part in linguistic activities through structural methods like dialogic reading. With screen tablets (iPad) we have got a number of picture book apps and especially adapted digital stories. However, there is not much research on whether qualities of digital technologies take care of or undermine the language stimulating effect of reading activities. Digital technologies have other material and technical characteristics than the book; the iPad screen radiates light and we handle tablets and books differently when we turn pages and point. Therefore a very interesting question is how different technology affordances affect linguistic interaction under dialogical reading.
DOI: 10.18712/nsd-nsd2332-v2
title: Internet-based Cognitive Therapy in the Treatment of Patients with Mental Health Problems in General Practice. A Novel Collaborative Model, 2016

description: In Scandinavian general practice one third of all consultations are due to mental health problems. Many GPs find it difficult to treat psychiatric patients. Specialist mental health care services suffer from many referrals with varying quality. There is a lack of psychiatric specialist health service. Patients will have to wait 3- 6 months for specialist treatment. This delay often aggravates patient symptoms. To overcome varying quality by GPs and referral delay, we need new approaches to patient treatment followed by a more efficient use of the limited resources in the specialized health care. In Northern Norway, 32 % of the population live in rural areas and there is 0,59 psychologist per 1000 inhabitants compared to 1,11 per 1000 in the urban areas of Oslo and Akershus. Long travelling distances to regional hospitals, longer waiting lists, and fewer psychiatric spesialists add to patient sufferings. This also applies to many rural areas in the other Scandinavian countries. By slightly modifying and applying an already existing and well tested internet self help programme for treatment of mental problems and combined with visits to GPs, this project investigated a novel approach of collaboration between patients, GPs and specialist mental health care professionals. The aim was to obtain a more efficient and more qualified patient treatment, better referrals to specialist and safer transition from specialist health care back to GPs. 

Research question 1: Can the use of the internet-based self-help program BlueMood result in a novel approach of cooperation between patient and general practitioners and yield improved diagnostics and treatment of patients seeking help for depression? 
Research question 2: Will the use of BlueMood in general practice, result in more efficient referral practices and novel ways of collaboration between GPs and mental health care professionals? 
Research question 3: Will the use of the BlueMood increase GPs' coping skills in treating patients with mental health problems?
DOI: 10.18712/nsd-nsd2333-v1
title: Faroe Bank Channel Overflow: Dynamics and Mixing, 2013

description: The aim of this project was to investigate the mixing and entrainment of the dense oceanic overflow from the Faroe Bank Channel. A large part of the deep, cold waters in the Nordic Seas flow out through the Faroe Bank Channel and into the North Atlantic as a subsea flow. These currents flow over the thresholds between the Nordic Seas and The North Atlantic and mix with the surrounding water masses, and become an important part of the global ocean circulation and the climate. Since there is a lack of observations and we don't quite understand how the water masses mix, these processes are poorly represented in climate models. The mixing happens at a small scale (0,1-1 m), but are dependent on processes on a larger scale (10 m - 100 km). The connection between what happens at a small and large scale is of great importance, and requires dedicated and complex observation systems as well as process based observations. Expertise and new instrumentation were united in this project to meet these requirements. The goal was, based on observations, to improve the knowledge about the dynamics and mixing in dense deep ocean currents, with a special focus on the Faroe Bank Channel. Detailed measurements of the movements were gathered, from a large scale to the smaller scales where the energy “died out”. The observations were collected from ships and gliders, and from instrumented rigs deployed in the ocean over a whole year. The data set from these rigs are unique in the way that they for the first time provide us with measurements over a cross section that covers width and height of the whole outflow area. This made it possible to make a heat budget over the outflow area, which in turn produced time series of vertical mixing, volume transport and heat content. Data is available for downloading at www.pangaea.de. For further information regarding "Faroe Bank Channel Overflow: Dynamics and Mixing, 2013", please contact the primary investigator.
DOI: 10.18712/nsd-nsd2335-1-v1
title: User Survey of Norwegian Students Studying Abroad During the Second Year of Upper Secondary School, 2016 (part 1)

description: The "User Survey of Norwegian Students Studying Abroad During the Second Year of Upper Secondary School (Vg2), 2016" was carried out by ideas2evidence on behalf of SIU. This file contains no information about student countries. The background for the project was the Ministry of Education and Research's directive F02-14, where SIU was asked to carry out a user survey to increase the knowledge on students' experience of exchange abroad with the use of an approved exchange organization. The survey aimed to give information on whether or not the terms of approval still were fullfilled, and to give insight to quality of the students' experience of exchange abroad. This dataset includes data from the first user survey, and norwegian students staying abroad during their second year of upper secondary school in 2015-16. Organizations with few answers are recoded to "99- Other organizations". A file with information on students countries is also available for downloading. Data are freely available for downloading.
DOI: 10.18712/nsd-nsd2335-2-v1
title: User Survey of Norwegian Students Studying Abroad During the Second Year of Upper Secondary School, 2016 (part 2)

description: The "User Survey of Norwegian Students Studying Abroad During the Second Year of Upper Secondary School (Vg2), 2016" was carried out by ideas2evidence on behalf of SIU. This file contains no information about counties. The background for the project was the Ministry of Education and Research's directive F02-14, where SIU was asked to carry out a user survey to increase the knowledge on students' experience of exchange abroad with the use of an approved exchange organization. The survey aimed to give information on whether or not the terms of approval still were fullfilled, and to give insight to quality of the students' experience of exchange abroad. This dataset includes data from the first user survey, and norwegian students staying abroad during their second year of upper secondary school in 2015-16. Organizations with few answers are recoded to "99- Other organizations". Students countries with few answers are recoded to «99 - Other countries». A file with information on counties is also available for downloading. Data are freely available for downloading.
DOI: 10.18712/nsd-nsd2338-v1
title: Chronic Skin Diseases, Depression, Self-esteem and Body Image Among Adolscents in Oslo, 2009

description: Negative self-evaluation is central in the maintenance of depression, and low self-esteem among depressed individuals is described with experienced feelings of inadequacy, inferiority, worthlessness and incompetence. Self-esteem related to body image is salient among adolescents especially females. The experienced body image is disturbed when the individual is depressed or suffers from a disfiguring disease like on a visual part of the body. It has been shown among adults that chronic skin diseases are common in the community (25%) and highly associated with psychosocial factors. Little is known about these issues among adolescents. The following research questions were raised in the project “Chronic Skin Diseases, Depression, Self-esteem and Body Image Among Adolescents in Oslo, 229”. All questions focused on gender and ethnic differences: How prevalent were common chronic skin diseases, like psoriasis, eczema and acne? How strong was the association between common chronic skin diseases, depression, self-esteem and disturbed body image? Was the visibility an explanatory factor for disturbed body image? The method used to answer these questions was an epidemiological population-based study carried out in 2004 and conducted by the Institute of General Practice and Preventive Medicine, University of Oslo, and the Norwegian Institute of Public Health. A questionnaire was answered by all pupils aged 18-19 years old; 2183 responded and the participating rate was 91%. Information was collected on psycho-social factors, well- being, self-reported health and life style. Approval was given by the Regional Committee for Medical Research Ethics and the Norwegian Data Inspectorate. This project represented an opportunity to build up and strengthen research in Norway on adolescence with an active cooperation with colleagues both nationally and internationally. The project aimed at exploring the association of somatic disease and mental health. It is a contribution to understanding the needs of this age group in order to organize adequate health care, as well as to target prevention strategies.
DOI: 10.18712/nsd-nsd2339-v1
title: Non-Gaussian Time Series and Nonlinear Dependence in Finance Markets, 2016

description: Two key statistical features of finance markets are non-linearity and Non-Gaussianity. Between 2011 and 2012, Dag Tjøstheim coordinated the research of the project "Non-Guassian Time Series and Nonlinear Dependence", financed by The Finance Market Fund. The activity of the project was spread over three sub-projects, namely i) Local Gaussian correlation, ii) Nonlinear cointegration and iii) Integer-valued time series. In the referee report for the project it was pointed out that i) was most relevant for financial markets. Therefore the focus was directed towards this in the project "Non-Gaussian Time Series and Nonlinear Dependence in Finance Markets, 2016", for which metadata is presented here. Topics from i) that received attention were multivariate heavy tail dependence, multivariate extreme events, and multivariate portfolio analysis and risk. In addition we considered nonlinear cointegration theory using local Gaussian correlation, this combining i) and ii). Finally we explored the relationships to multiple copula theory, in particular the vine theory. All of this was relevant for the statistical analysis of financial markets.
DOI: 10.18712/nsd-nsd2340-v1
title: Regulation of Chromatin Remodeling and Gene Activity by A-kinase Anchoring Proteins, 2015

description: The goal of this project was to characterize in detail the molecular function of the nuclear AKAP, AKAP95, on the regulation of chromatin remodeling and gene activity in a differentiation context. The experimental strategy combined stem cell differentiation with state-of-the-art genome-scale epigenetics and bioinformatics, functional chromatin-based assays and RNAi/mutant. The data includes: 
- AKAP and FUS_genomics: Genomics viewer (browser) files and peak analysis for AKAP95 and FUS 
- AKAP and TPR: Images, microsopy videos, analyses, text/observations, manuscript. Data on BioID experiments and analysis 
- AKAP ChIP data and analysis. ChIP data_browser folder: genomics data for genome browsing (viewing). Analysis folder: various datasets. AKAP95ChIPGeneNames folder: gene lists 
- BioID: Mass-spectrometry proteomics data files
DOI: 10.18712/nsd-nsd2341-v1
title: Remittances, Standard of Living and Integration: A Study of Tamils Living in Scandinavian Capitals (REMIT-INT), 2016

description: The primary objective of the project was to study the remittance practices and their consequences with standard of living and the integration process of Tamils living in Scandinavia. The data was collected in Oslo, Stockholm and two places in Denmark. The study aims to map out the present pattern of remittance sending practices, positive and negative effects of remittance practices and the connection between remittance practice and the place. Scandinavian countries, though with many similarities among them, do present certain differences in the context of immigrant integration policy. The scale difference between the places does also matter in the context of the study, making a study of this nature both challenging and interesting. Similar numbers of Tamils live at present in Norway and Denmark numbering around 13,000. The population in Sweden is far smaller. The project adopts three hypotheses. These are described as follows: 1. Remittance sending has been largely a first-generation practice and the moral obligation for sending remittances is minimal among the second generation Tamils. 2. Remittance sending has impact on standard of living; and positively contributes to better labour market and housing conditions, but negatively contributes to health problems and relative poverty among remittance-sending Tamils and thus plays an important role in integration issues. 3. Remittance practices have association to place differences and have an impact on standard of living and integration through the differences in places and available social capital. For further information about ”Remittances, Standard of Living and Integration: A Study of Tamils Living in Scandinavian Capitals (REMIT-INT), 2016”, please contact the principal investigator.
DOI: 10.18712/nsd-nsd2341-v2
title: Remittances, Standard of Living and Integration: A Study of Tamils Living in Scandinavian Capitals (REMIT-INT), 2016

description: The primary objective of the project was to study the remittance practices and their consequences with standard of living and the integration process of Tamils living in Scandinavia. The data was collected in Oslo, Stockholm and two places in Denmark. The study aims to map out the present pattern of remittance sending practices, positive and negative effects of remittance practices and the connection between remittance practice and the place. Scandinavian countries, though with many similarities among them, do present certain differences in the context of immigrant integration policy. The scale difference between the places does also matter in the context of the study, making a study of this nature both challenging and interesting. Similar numbers of Tamils live at present in Norway and Denmark numbering around 13,000. The population in Sweden is far smaller. 

The project adopts three hypotheses. These are described as follows:
1.	Remittance sending has been largely a first-generation practice and the moral obligation for sending remittances is minimal among the second generation Tamils.
2.	Remittance sending has impact on standard of living; and positively contributes to better labour market and housing conditions, but negatively contributes to health problems and relative poverty among remittance-sending Tamils and thus plays an important role in integration issues.
3.	Remittance practices have association to place differences and have an impact on standard of living and integration through the differences in places and available social capital. 

For further information about ”Remittances, Standard of Living and Integration: A Study of Tamils Living in Scandinavian Capitals (REMIT-INT), 2016”, please contact the principal investigator.
DOI: 10.18712/nsd-nsd2342-v2
title: Norwegian Citizen Panel Wave 4, 2015

description: The Norwegian Citizen Panel is a platform for internet surveys of public opinion in important areas of society and politics in Norway. Participants are randomly recruited from the Norwegian population register, and they are encouraged to participate over time. The panel was fielded for the first time the fall of 2013 and the survey is carried out twice a year. The University of Bergen owns and is responsible for the Citizen panel. The company ideas 2 evidence recruits respondents, produces the survey, and provides documentation of the data. Data is stored and shared by NSD – Norwegian Centre for Research Data. The Norwegian Citizen Panel welcomes research proposals for survey content. More information about calls and other updates is available at www.medborger.uib.no.