DOI: 10.57760/sciencedb.o00130.04296
title: Analysis of antibody detection data of Mycoplasma pneumoniae in a hospital in Beijing City from 2017 to 2024
title: 2017—2024年北京市某医院肺炎支原体抗体检测数据分析

description: Objective  To explore the distribution characteristics of Mycoplasma pneumoniae (MP) antibody detection data in our hospital, provide data reference for the prevention and control of MP infections. Methods  A single-center retrospective study was conducted on patients (aged 0 to 105 years) with suspected MP infection from the outpatient, emergency and inpatient departments of Peking University Third Hospital between March 2017 to February 2024. MP antibodies in patient serum were detected using passive agglutination. χ² was used to analyze the differences in the positive rate of MP antibodies among different genders, ages, and seasons. Results  Among the 20,639 patients, the positive rate of MP antibodies was 23.19%, with a higher positive rate in females (27.16%) compared to males (19.90%)(χ²=151.191, P&lt;0.01). The positive rate in children (37.13%) was significantly higher than in adults(15.47%, χ²=1,246.433, P&lt;0.01). The 6 to &lt;12 year age group (63.11%) had the highest positive rate of MP antibodies, followed by 12 to &lt;18 year old group (56.78%). The positive rate of MP antibodies increased with age from 0 to 12 years old but gradually decreased after 12 to &lt;18 years old (P trend&lt;0.01). The annual MP antibody positivity rates from 2017 to 2023 were 26.92%, 29.23%, 27.46%, 18.43%, 17.16%, 11.89%, and 23.72%, respectively, with statistically significant differences among the years (χ² = 387.519, P &lt; 0.01). The combined positivity rate was highest in the autumn season (χ² = 242.560, P &lt; 0.01). The positive rates of MP antibodies before the epidemic (2017-2019), during the epidemic (2020-2022), and after the epidemic (2023-2024) were 28.00%, 16.60%, and 21.84%, respectively, with statistically significant differences among the three periods(χ²=295.845, P&lt;0.01).The monthly positive rate of MP fluctuated significantly in different years (5.63% to 43.11%). In the MP antibody titer, qualitative testing was conducted on 4,563 patients and 16,076 patients had a semi-quantitative MP antibody titer of ≥1:160 with a positive rate of 16.03%. Among the proportion of children with high titers of MP antibodies ≥1:1,280 was 11.11%. Conclusion  The positive rate of MP antibodies in Peking University Third Hospital varies by gender, age, and season. The infection shows periodic epidemic changes with a peak in autumn, mainly affecting children and adolescents.
description: Objective  To explore the distribution characteristics of Mycoplasma pneumoniae (MP) antibody detection data in our hospital, provide data reference for the prevention and control of MP infections. Methods  A single-center retrospective study was conducted on patients (aged 0 to 105 years) with suspected MP infection from the outpatient, emergency and inpatient departments of Peking University Third Hospital between March 2017 to February 2024. MP antibodies in patient serum were detected using passive agglutination. χ² was used to analyze the differences in the positive rate of MP antibodies among different genders, ages, and seasons. Results  Among the 20,639 patients, the positive rate of MP antibodies was 23.19%, with a higher positive rate in females (27.16%) compared to males (19.90%)(χ²=151.191, P&lt;0.01). The positive rate in children (37.13%) was significantly higher than in adults(15.47%, χ²=1,246.433, P&lt;0.01). The 6 to &lt;12 year age group (63.11%) had the highest positive rate of MP antibodies, followed by 12 to &lt;18 year old group (56.78%). The positive rate of MP antibodies increased with age from 0 to 12 years old but gradually decreased after 12 to &lt;18 years old (P trend&lt;0.01). The annual MP antibody positivity rates from 2017 to 2023 were 26.92%, 29.23%, 27.46%, 18.43%, 17.16%, 11.89%, and 23.72%, respectively, with statistically significant differences among the years (χ² = 387.519, P &lt; 0.01). The combined positivity rate was highest in the autumn season (χ² = 242.560, P &lt; 0.01). The positive rates of MP antibodies before the epidemic (2017-2019), during the epidemic (2020-2022), and after the epidemic (2023-2024) were 28.00%, 16.60%, and 21.84%, respectively, with statistically significant differences among the three periods(χ²=295.845, P&lt;0.01).The monthly positive rate of MP fluctuated significantly in different years (5.63% to 43.11%). In the MP antibody titer, qualitative testing was conducted on 4,563 patients and 16,076 patients had a semi-quantitative MP antibody titer of ≥1:160 with a positive rate of 16.03%. Among the proportion of children with high titers of MP antibodies ≥1:1,280 was 11.11%. Conclusion  The positive rate of MP antibodies in Peking University Third Hospital varies by gender, age, and season. The infection shows periodic epidemic changes with a peak in autumn, mainly affecting children and adolescents.