DOI: 10.5281/zenodo.269650
title: Averaged results of blood flow simulations with discrete RBC tracking for microvascular networks

description: The dataset contains the results for blood flow simulations in 3 cerebral micorvascular networks.The microvascular networks are from the mouse parietal cortex (Blinder et al., 2013) and embedded in a tissue volume of approximately 1 cubic mm. For the blood flow simulations we used a numercial model with discrete tracking of RBCs which is described in Schmid et al., 2017. For each network the following data are provided:<br> - Microvascular network with averaged flow and pressure field, as well as averaged values for the distribution and motion of red blood cells (RBCs).<br> - RBC trajectories describing the motion of individual RBCs through the microvascular networks.<br> - The data is stored as a graph, i.e. vertices connected by edges.<br> - Details regarding the simulation parameters can be found in Schmid et al., 2017.<br> - Data format (pickle - files containing python dictonairies).<br> <br> <strong>Microvascular networks:</strong><br> <strong>edgesDict.pkl:</strong> dictionary with edge related data (dictionary keys: flow [um^3/ms], diameter [um], tuple [-], httBC [-], nkind [-], length [um], htt [-], nRBC [-], diameters [um], points [um])<br> <strong>verticesDict.pkl:</strong> dictionary with vertex related data (dictionary keys: pressure [mmHg], coordinates [um], pBC [mmHg]) Additional comments on dictionary keys:<br> - pBC: pressure boundary conditions. 'None' for internal nodes. Assigned based on the hierarchical boundary conditions approach (see Schmid et al. 2017 for details)<br> - tuple: connectivity of graph, tuple of vertices<br> - httBC: tube hematocrit boundary conditions. 'None' for internal nodes. Constant value assigned.<br> - nkind: integere to describe the vessel type. 0: pial artery, 1: pial venule, 2: descending arteriole, 3: ascending venule, 4: capillaries, 5: unknown<br> - htt: tube hematocrit<br> - nRBC: number of red blood cells<br> - points: list of tortuous vessel coordinates per edge<br> - diameters: local diameter measurements associated to the 'points' key. <br> <strong>RBC trajectories:</strong><br> <strong>RBC_trajectories.pkl: </strong>dictonary for each RBC with relevant tracking data (dictionary key: RBC index). The relavant tracking data per RBC is stored in another dictionary with the following keys: edges, lengths, times, pressure, nkindsMod, RBCleft Additional comments on dictionary keys per RBC:<br> - RBCleft: bool to indicate that RBC left the computational domain<br> - edges: edge indices through which the RBC moves on its way through the vasculature<br> - pressure: pressure [mmHg] values at the nodes along the RBC trajectory<br> - times: time [ms] the RBC spends in the respective edge segment<br> - nkindsMod: nkind at the nodes along the RBC trajectory <br> - lengths: cummulative length travelled [um]
description: {"references": ["Blinder P, Tsai PS, Kaufhold JP, Knutsen PM, Suhl H, Kleinfeld D. The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nature Neurosci. 2013;16(7):889\u2013897", "Schmid F, Tsai PS, Kleinfeld D, Jenny P, Weber B. Depth-Dependent Flow and Pressure Characteristics in Cortical Microvascular Networks. PLOS Computational Biology. 2017. doi: 10.1371/journal.pcbi.1005392"]}