cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20004815
title: Cost-effectiveness analysis of nivolumab plus ipilimumab plus two cycles of platinum-doublet chemotherapy versus platinum-doublet chemotherapy alone for first-line treatment of stage IV or recurrent non-small cell lung cancer in the United States

description: This economic analysis evaluated the cost-effectiveness of nivolumab (NIVO) plus ipilimumab (IPI) plus two cycles of platinum-doublet chemotherapy (PDC) compared with four cycles of PDC as first-line treatment for patients with advanced NSCLC in the United States (US). A partitioned survival model was constructed with three mutually exclusive health states: progression free, progressed disease, and death. The analysis was conducted from a US healthcare payer perspective, using a time horizon of 25 years. Costs and outcomes were discounted at 3% annually. Survival outcomes from CheckMate 9LA were extrapolated with longer follow-up data from CheckMate 227 Part 1 (NIVO + IPI) and validated against data from other relevant clinical trials and real-world registries. Health-related quality of life utility values were derived from EQ-5D-3L data collected in CheckMate 9LA. US-specific costs (2020 dollars) were used for disease management; drug acquisition, administration, and monitoring; end-of-life care; adverse events; and subsequent treatments. Model outcomes included life years (LYs) gained, quality-adjusted LYs (QALYs) gained, and incremental cost-effectiveness ratio (ICER) for NIVO + IPI + PDC versus PDC. Sensitivity and scenario analyses were conducted. NIVO + IPI + PDC was associated with higher projected health benefits than PDC, including gains in LYs (3.71 vs 1.89) and QALYs (2.86 vs 1.37), and higher costs ($317,581 vs $119,909). The ICER was $132,960/QALY gained. NIVO + IPI + PDC had a 78–100% probability of being cost-effective at a willingness-to-pay threshold of $150,000–$250,000/QALY. Sensitivity and scenario analyses indicated that the results were robust to changes in key parameters. The inherent limitation in extrapolating clinical trial data was mitigated using data from the more mature CheckMate 227 Part 1 trial and validating the outcomes against data from other relevant trials and real-world registries. NIVO + IPI + PDC (two cycles) provides a new first-line treatment option for patients with advanced NSCLC that is cost-effective within a range considered acceptable in the US.
DOI: 10.6084/m9.figshare.20004815.v1
title: Cost-effectiveness analysis of nivolumab plus ipilimumab plus two cycles of platinum-doublet chemotherapy versus platinum-doublet chemotherapy alone for first-line treatment of stage IV or recurrent non-small cell lung cancer in the United States

description: This economic analysis evaluated the cost-effectiveness of nivolumab (NIVO) plus ipilimumab (IPI) plus two cycles of platinum-doublet chemotherapy (PDC) compared with four cycles of PDC as first-line treatment for patients with advanced NSCLC in the United States (US). A partitioned survival model was constructed with three mutually exclusive health states: progression free, progressed disease, and death. The analysis was conducted from a US healthcare payer perspective, using a time horizon of 25 years. Costs and outcomes were discounted at 3% annually. Survival outcomes from CheckMate 9LA were extrapolated with longer follow-up data from CheckMate 227 Part 1 (NIVO + IPI) and validated against data from other relevant clinical trials and real-world registries. Health-related quality of life utility values were derived from EQ-5D-3L data collected in CheckMate 9LA. US-specific costs (2020 dollars) were used for disease management; drug acquisition, administration, and monitoring; end-of-life care; adverse events; and subsequent treatments. Model outcomes included life years (LYs) gained, quality-adjusted LYs (QALYs) gained, and incremental cost-effectiveness ratio (ICER) for NIVO + IPI + PDC versus PDC. Sensitivity and scenario analyses were conducted. NIVO + IPI + PDC was associated with higher projected health benefits than PDC, including gains in LYs (3.71 vs 1.89) and QALYs (2.86 vs 1.37), and higher costs ($317,581 vs $119,909). The ICER was $132,960/QALY gained. NIVO + IPI + PDC had a 78–100% probability of being cost-effective at a willingness-to-pay threshold of $150,000–$250,000/QALY. Sensitivity and scenario analyses indicated that the results were robust to changes in key parameters. The inherent limitation in extrapolating clinical trial data was mitigated using data from the more mature CheckMate 227 Part 1 trial and validating the outcomes against data from other relevant trials and real-world registries. NIVO + IPI + PDC (two cycles) provides a new first-line treatment option for patients with advanced NSCLC that is cost-effective within a range considered acceptable in the US.
DOI: 10.6084/m9.figshare.20004539
title: Sr-Nd-Hf isotopic constraint on provenance of the modern Zambezi River sand sediments, Southern Africa

description: Sr-Nd-Hf isotope data of river sands from branches and main streams of the Zambezi River
DOI: 10.6084/m9.figshare.20004539.v2
title: Sr-Nd-Hf isotopic constraint on provenance of the modern Zambezi River sand sediments, Southern Africa

description: Sr-Nd-Hf isotope data of river sands from branches and main streams of the Zambezi River
DOI: 10.6084/m9.figshare.20004539.v1
title: Sr-Nd-Hf isotopic constraint on provenance of the modern Zambezi River sand sediments, Southern Africa

description: Sr-Nd-Hf isotope data of river sands from branches and main streams of the Zambezi River
DOI: 10.5281/zenodo.6616682
title: The Evaluation and Construction of the Capacities of Urban Innovation Chains Based on Efficiency Improvement

description: This paper studies urban innovation activities from the perspective of improving the efficiency of innovation chains and explores the operation patterns of urban innovation chains. The connotation of the urban innovation chain is analyzed according to the process of the innovation chain and the characteristics of urban innovation activities. The urban innovation chain can be divided into three stages (original innovation, technological innovation, and innovation transformation) and establishes an indicator system for evaluating the three capacities of the urban innovation chain using the development level of strategic emerging industries as an indicator to measure the efficiency of the urban innovation chain and analysing the relationship between these three constructed capacities in Chinese national innovative cities. Published data on China’s national innovative cities are used to measure the capacity of the urban innovation chain. The development of strategic emerging industries measures cities’ innovation performance, and an inductive approach is applied to analyze the relationship between the capacity construction of the urban innovation chain and innovation performance in innovative cities. This study found that the capacity of the urban innovation chain positively affected urban innovation performance and that the balanced development of the three capacities of the urban innovation chain positively affected urban innovation performance; when urban innovation performance was at its highest, the contribution of original innovation capacity to innovation performance was significantly greater than that of the other two capacities; an inverted U curve illustrated the relationship between the improvement of urban innovation performance and the balance of the three capacities of the urban innovation chain. The research conclusions of this paper enrich the relevant theories of innovation chain, provide reference for the construction of the UIC, and promote the development of strategic emerging industries.
DOI: 10.5281/zenodo.6616681
title: The Evaluation and Construction of the Capacities of Urban Innovation Chains Based on Efficiency Improvement

description: This paper studies urban innovation activities from the perspective of improving the efficiency of innovation chains and explores the operation patterns of urban innovation chains. The connotation of the urban innovation chain is analyzed according to the process of the innovation chain and the characteristics of urban innovation activities. The urban innovation chain can be divided into three stages (original innovation, technological innovation, and innovation transformation) and establishes an indicator system for evaluating the three capacities of the urban innovation chain using the development level of strategic emerging industries as an indicator to measure the efficiency of the urban innovation chain and analysing the relationship between these three constructed capacities in Chinese national innovative cities. Published data on China’s national innovative cities are used to measure the capacity of the urban innovation chain. The development of strategic emerging industries measures cities’ innovation performance, and an inductive approach is applied to analyze the relationship between the capacity construction of the urban innovation chain and innovation performance in innovative cities. This study found that the capacity of the urban innovation chain positively affected urban innovation performance and that the balanced development of the three capacities of the urban innovation chain positively affected urban innovation performance; when urban innovation performance was at its highest, the contribution of original innovation capacity to innovation performance was significantly greater than that of the other two capacities; an inverted U curve illustrated the relationship between the improvement of urban innovation performance and the balance of the three capacities of the urban innovation chain. The research conclusions of this paper enrich the relevant theories of innovation chain, provide reference for the construction of the UIC, and promote the development of strategic emerging industries.
DOI: 10.6084/m9.figshare.19714663
title: Adaptive increases in respiratory capacity and O2 affinity of subsarcolemmal mitochondria from skeletal muscle of high-altitude deer mice

description: Measurements of respiration, O2 kinetics, ROS emission, and enzyme activity in subsarcolemmal and intermyofibrillar mitochondria isolated from the gastrocnemius muscle of highland deer mice and lowland white-footed mice
DOI: 10.5281/zenodo.6616659
title: Well Sorted results from the UK Astronomy community

description: Submissions to Well Sorted from the UK Astronomy community. Members were asked to highlight their scientific interests to use data from the SKA and pathfinder facilities using MID and mixed frequencies, and for LOW frequencies. These were used as a starting point for the breakout groups in Workshop 1 Co-creating the UKSRC. <pre> </pre>
DOI: 10.5281/zenodo.6616658
title: Well Sorted results from the UK Astronomy community

description: Submissions to Well Sorted from the UK Astronomy community. Members were asked to highlight their scientific interests to use data from the SKA and pathfinder facilities using MID and mixed frequencies, and for LOW frequencies. These were used as a starting point for the breakout groups in Workshop 1 Co-creating the UKSRC. <pre> </pre>
DOI: 10.6084/m9.figshare.20004921
title: Pollen spectrum of Scaptotrigona aff. postica (Hymenoptera, Apidae, Meliponini) propolis from Barra do Corda, MA, Brazil

description: Propolis is a resinous substance collected by bees from different parts of a plant. Therefore, its quality is related to its botanical origin. The objective of the study was to verify whether the pollen types found indicate the botanical origin of their resins and contribute to understand the relationship of these bees with the vegetation surrounding the meliponary. Thirty one samples were collected over 12 months at seven day intervals. Pollen grains were extracted from the propolis and used to prepare microscope slides, after which identification, counting and determination of frequency classes was undertaken. A total of 94 pollen types were identified belonging to 35 plant families. Borreria verticillata (34.17%) was the most frequent pollen type, followed by Anadenanthera sp. (13.65%) and Mimosa caesalpiniifolia (10.5%). Fabaceae (38.37%) and Rubiaceae (34.18%) were the families with the highest pollen frequencies. There were also found 34 unique pollen types, i.e. types that only occur on a given month of the year which may be characterised as seasonal indicators for flowering species and thus infer data on their phenology. The results obtained were not enough to determine the botanical origin of the resins; however the wide variety of pollen types found in the propolis samples indicated a broad interaction between bees and plants and contributed toward the phytogeographic characterisation of the propolis.
DOI: 10.6084/m9.figshare.20004921.v1
title: Pollen spectrum of Scaptotrigona aff. postica (Hymenoptera, Apidae, Meliponini) propolis from Barra do Corda, MA, Brazil

description: Propolis is a resinous substance collected by bees from different parts of a plant. Therefore, its quality is related to its botanical origin. The objective of the study was to verify whether the pollen types found indicate the botanical origin of their resins and contribute to understand the relationship of these bees with the vegetation surrounding the meliponary. Thirty one samples were collected over 12 months at seven day intervals. Pollen grains were extracted from the propolis and used to prepare microscope slides, after which identification, counting and determination of frequency classes was undertaken. A total of 94 pollen types were identified belonging to 35 plant families. Borreria verticillata (34.17%) was the most frequent pollen type, followed by Anadenanthera sp. (13.65%) and Mimosa caesalpiniifolia (10.5%). Fabaceae (38.37%) and Rubiaceae (34.18%) were the families with the highest pollen frequencies. There were also found 34 unique pollen types, i.e. types that only occur on a given month of the year which may be characterised as seasonal indicators for flowering species and thus infer data on their phenology. The results obtained were not enough to determine the botanical origin of the resins; however the wide variety of pollen types found in the propolis samples indicated a broad interaction between bees and plants and contributed toward the phytogeographic characterisation of the propolis.
DOI: 10.6084/m9.figshare.20004924
title: In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)

description: ABSTRACT Aniba riparia (Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH• (EC50 of 296.2 μg mL-1) and ABTS•+ (EC50 of 450.1 μg mL-1), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 μg mL-1) and leishmanicidal activity on promastigotes of L. amazonensis (IC50 of 307.0 ± 79.6, 193.7 ± 44.3 and 81.8 ± 11.2 μg mL-1, respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.
DOI: 10.6084/m9.figshare.20004924.v1
title: In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)

description: ABSTRACT Aniba riparia (Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH• (EC50 of 296.2 μg mL-1) and ABTS•+ (EC50 of 450.1 μg mL-1), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 μg mL-1) and leishmanicidal activity on promastigotes of L. amazonensis (IC50 of 307.0 ± 79.6, 193.7 ± 44.3 and 81.8 ± 11.2 μg mL-1, respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.
DOI: 10.6084/m9.figshare.20004926
title: Hydroclimatic variables associated with El Nino and La Nina events at the Curuá-Una hydroelectric reservoir, Central Amazonia

description: ABSTRACT The anomalies of Sea Surface Temperature (SST) influence rainfall and therefore the regime of the rise and fall in the level of the rivers in the Amazon region. The aim of this study was to investigate the influence of the El Nino-Southern Oscillation (ENSO) on hydroclimatic variables and identify the existence of trends on these variables in the Curuá-Una hydroelectric reservoir in the West of the State of Pará. It was used 27 years of monthly precipitation and water flow data to identify possible trends using a non-parametric test (Mann Kendall, p&lt;0.05), and the standardized precipitation index (SPI) was also calculated. The results indicate a positive tendency of the influence of the ENSO on hydroclimatic variables, although it was observed that the rainfall did not increase over the period of 1977 to 2004. The SPI indicates that extreme events of precipitation are related to El Nino and La Nina and that lower precipitation periods were more intense in the decades of the 80´s and 90's. The results show that El Nino events can directly affect the water balance at the micro-watershed of Curuá-Una, as was observed in 2015.
DOI: 10.6084/m9.figshare.20004926.v1
title: Hydroclimatic variables associated with El Nino and La Nina events at the Curuá-Una hydroelectric reservoir, Central Amazonia

description: ABSTRACT The anomalies of Sea Surface Temperature (SST) influence rainfall and therefore the regime of the rise and fall in the level of the rivers in the Amazon region. The aim of this study was to investigate the influence of the El Nino-Southern Oscillation (ENSO) on hydroclimatic variables and identify the existence of trends on these variables in the Curuá-Una hydroelectric reservoir in the West of the State of Pará. It was used 27 years of monthly precipitation and water flow data to identify possible trends using a non-parametric test (Mann Kendall, p&lt;0.05), and the standardized precipitation index (SPI) was also calculated. The results indicate a positive tendency of the influence of the ENSO on hydroclimatic variables, although it was observed that the rainfall did not increase over the period of 1977 to 2004. The SPI indicates that extreme events of precipitation are related to El Nino and La Nina and that lower precipitation periods were more intense in the decades of the 80´s and 90's. The results show that El Nino events can directly affect the water balance at the micro-watershed of Curuá-Una, as was observed in 2015.
DOI: 10.6084/m9.figshare.20004929
title: New human case reports of cutaneous leishmaniasis by Leishmania (Viannia) naiffi in the Amazon region, Brazil

description: ABSTRACT Few cases of human cutaneous leishmaniasis (CL) caused by Leishmania naiffi were described in the medical literature. The aim of this study was to report and analyze new cases of L. naiffi in the period between the years 1992 to 2011. The strains were characterized by isoenzyme analysis. All patients assisted had small lesions; ranging from 1.0x1.0 mm and 13.5x11.5 mm. The lesions observed were widely distributed: 55.5% on the lower limb, 5.5% in the abdominal area, 16.6% on upper limb and 22.2% in upper limb and back. Seventy-two percent of patients had ulcerated lesions. Clinical course of the disease varied from 1 to 10 months. According to gender, most infected individuals were men (83.3%). The patients came from Amazonas (10), Pará (01) and Rondônia (01), north States of Brazil. Five patients were infected in experimental stations of the National Institute of Amazonian Research (INPA). Although the results of this study were similar to other reports in the literature, some of the patients had more of one skin lesion. It is also reported the first case of CL caused by L. naiffi in the State of Rondônia and identified an area of disease transmission in the experimental station of INPA.
DOI: 10.6084/m9.figshare.20004929.v1
title: New human case reports of cutaneous leishmaniasis by Leishmania (Viannia) naiffi in the Amazon region, Brazil

description: ABSTRACT Few cases of human cutaneous leishmaniasis (CL) caused by Leishmania naiffi were described in the medical literature. The aim of this study was to report and analyze new cases of L. naiffi in the period between the years 1992 to 2011. The strains were characterized by isoenzyme analysis. All patients assisted had small lesions; ranging from 1.0x1.0 mm and 13.5x11.5 mm. The lesions observed were widely distributed: 55.5% on the lower limb, 5.5% in the abdominal area, 16.6% on upper limb and 22.2% in upper limb and back. Seventy-two percent of patients had ulcerated lesions. Clinical course of the disease varied from 1 to 10 months. According to gender, most infected individuals were men (83.3%). The patients came from Amazonas (10), Pará (01) and Rondônia (01), north States of Brazil. Five patients were infected in experimental stations of the National Institute of Amazonian Research (INPA). Although the results of this study were similar to other reports in the literature, some of the patients had more of one skin lesion. It is also reported the first case of CL caused by L. naiffi in the State of Rondônia and identified an area of disease transmission in the experimental station of INPA.
DOI: 10.6084/m9.figshare.20004930
title: Patterns of mollusc distribution in mangroves from the São Marcos Bay, coast of Maranhão State, Brazil

description: ABSTRACT The diversity and distribution of molluscs from the Amazon Coast of Maranhão State, Brazil, are poorly understood. The aim of this study was to investigate how molluscs in two mangrove creeks (Buenos Aires and Tronco) at the São Marcos Bay, coast of the Maranhão State, respond to spatial and temporal variations in the environment. Sampling was performed in the intertidal area along three zones established using a straight line transect of 100 m. Abiotic variables of water and sediment were measured at each creek. We found 5,912 specimens belonging to 23 species and 15 families of epifaunal and infaunal molluscs. The patterns of their distribution in the two creeks were different. Salinity, dissolved oxygen, and rainfall were the main variables that affected the temporal distribution of molluscs. We found low species richness in the overall mollusc composition. Diversity in the Buenos Aires Creek was lower than that observed in the Tronco Creek, possibly because of activities of a port located in proximity to the former. The spatial distribution of molluscs along the zones followed an abundance and diversity gradient, mainly influenced by exposure time during low tide. Port activities may influence the patterns of mollusc distribution in the surrounding mangroves, and we thus highlight the importance of management and monitoring of these areas.