cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/rjb9d57gg5
title: Donepezil Hydrochloride Ameliorates Peripheral Inflammation in Vascular Dementia by Regulating Treg Homeostasis. Sai Qi

description: Background: Vascular dementia (VD) is the second most common type of dementia after Alzheimer's disease, with complex pathology and high prevalence. Donepezil hydrochloride, a classic acetylcholinesterase inhibitor, has been clinically shown to improve cognitive function in VD patients. Recent studies suggest it also possesses neuroprotective and anti-inflammatory properties. Peripheral inflammation and immune dysregulation can drive neuroinflammation and cognitive impairment. Regulatory T cells (Tregs) are crucial for maintaining immune homeostasis and preventing excessive inflammation. Decreased Treg number and function have been linked to cognitive impairment in VD. However, it remains unclear whether donepezil alleviates cognitive deficits in VD by modulating peripheral Treg homeostasis and reducing peripheral inflammation. 
Methods: 70 patients with VD were recruited and assigned to the donepezil group, while 70 normal elderly individuals were recruited and assigned to the normal control group. Both groups underwent neurobehavioral scale testing, flow cytometry, and enzyme-linked immunosorbent assay, and correlation analysis was conducted on the test results of patients with VD. 
Results: Donepezil hydrochloride ameliorated cognitive impairment in VD patients, reduced apoptosis of peripheral blood lymphocyte subsets (Annexin V CD4+ and Annexin V CD8+ T cells), increases in the proportions of peripheral blood(CD3+ and CD4+ T cells, Tregs, Ki67+CD3+, Ki67+CD4+ and Ki67+CD8+ T cells, Ki67+Tregs, as well as the CD4+/CD8+ T-cell ratio). Furthermore, it decreased pro-inflammatory cytokines (IL-1β, TNF-α), and elevated anti-inflammatory cytokines (IL-2, IL-4, IL-10, IL-35, TGF-β1) in the peripheral blood. In VD patients, a strong negative correlation existed between changes in ADAS-cog scores and the proportion of Tregs. Changes in the proportion of CD4+ T cells showed a strong negative correlation with that of CD8+ T cells and a positive correlation with that of Tregs. Change in the proportion of Tregs exhibited a strong positive correlation with changes in IL-10, IL-35, and TGF-β1 levels.
Conclusions: It was found that the improvement of cognitive ability in patients with VD by donepezil hydrochloride may be closely related to the increase in the proportion and function of Tregs and the reduction in peripheral inflammation levels.
DOI: 10.17632/rjb9d57gg5.1
title: Donepezil Hydrochloride Ameliorates Peripheral Inflammation in Vascular Dementia by Regulating Treg Homeostasis. Sai Qi

description: Background: Vascular dementia (VD) is the second most common type of dementia after Alzheimer's disease, with complex pathology and high prevalence. Donepezil hydrochloride, a classic acetylcholinesterase inhibitor, has been clinically shown to improve cognitive function in VD patients. Recent studies suggest it also possesses neuroprotective and anti-inflammatory properties. Peripheral inflammation and immune dysregulation can drive neuroinflammation and cognitive impairment. Regulatory T cells (Tregs) are crucial for maintaining immune homeostasis and preventing excessive inflammation. Decreased Treg number and function have been linked to cognitive impairment in VD. However, it remains unclear whether donepezil alleviates cognitive deficits in VD by modulating peripheral Treg homeostasis and reducing peripheral inflammation. 
Methods: 70 patients with VD were recruited and assigned to the donepezil group, while 70 normal elderly individuals were recruited and assigned to the normal control group. Both groups underwent neurobehavioral scale testing, flow cytometry, and enzyme-linked immunosorbent assay, and correlation analysis was conducted on the test results of patients with VD. 
Results: Donepezil hydrochloride ameliorated cognitive impairment in VD patients, reduced apoptosis of peripheral blood lymphocyte subsets (Annexin V CD4+ and Annexin V CD8+ T cells), increases in the proportions of peripheral blood(CD3+ and CD4+ T cells, Tregs, Ki67+CD3+, Ki67+CD4+ and Ki67+CD8+ T cells, Ki67+Tregs, as well as the CD4+/CD8+ T-cell ratio). Furthermore, it decreased pro-inflammatory cytokines (IL-1β, TNF-α), and elevated anti-inflammatory cytokines (IL-2, IL-4, IL-10, IL-35, TGF-β1) in the peripheral blood. In VD patients, a strong negative correlation existed between changes in ADAS-cog scores and the proportion of Tregs. Changes in the proportion of CD4+ T cells showed a strong negative correlation with that of CD8+ T cells and a positive correlation with that of Tregs. Change in the proportion of Tregs exhibited a strong positive correlation with changes in IL-10, IL-35, and TGF-β1 levels.
Conclusions: It was found that the improvement of cognitive ability in patients with VD by donepezil hydrochloride may be closely related to the increase in the proportion and function of Tregs and the reduction in peripheral inflammation levels.
DOI: 10.17632/hwhcdr945d
title: Data for: Crystallinity-dependent transformation of layered manganese oxides: implications for the mineral diversity of manganese oxides in nature

description: Raw data for figures of SR-XRD patterns and Raman spectra in the manuscript by Wen et al., as "Crystallinity-dependent transformation of layered manganese oxides: implications for the mineral diversity of manganese oxides in nature".
DOI: 10.17632/hwhcdr945d.2
title: Data for: Crystallinity-dependent transformation of layered manganese oxides: implications for the mineral diversity of manganese oxides in nature

description: Raw data for figures of SR-XRD patterns and Raman spectra in the manuscript by Wen et al., as "Crystallinity-dependent transformation of layered manganese oxides: implications for the mineral diversity of manganese oxides in nature".
DOI: 10.17632/5tfht8z769.2
title: Parameter Optimization of floating foundations for Offshore Wind Turbines Based on Machine Learning

description: With the increasing global demand for renewable energy, offshore wind power generation has attracted great attention, especially the development of floating offshore wind turbines .Offshore floating wind turbine foundations involve multiple key dimensional parameters that strongly interact and influence the system's extreme motion response. Traditional optimization methods struggle to handle these complex couplings, necessitating AI-driven approaches like neural networks for intelligent parameter optimization. However, limited dataset availability in this emerging field poses a challenge. This paper proposes a small-sample-based optimization method for wind turbine foundation design. The HexaSemi-submersible FOWT was optimized by tuning four key parameters :column spacing (L), platform draft (T), column diameter (D), and caisson height (h). OpenFAST simulated motion responses, followed by a BP neural network modeling parameter-displacement relationships. Coupled with genetic algorithms, this approach reduced platform displacement by 16.03% versus the original design configuration.
DOI: 10.17632/f5mmsp8mmj
title: NMN mitigates high-altitude hypoxia-induced cognitive impairment by inhibiting microglial ferroptosis. Xu et al.

description: The Upated original data material for this manuscript.
DOI: 10.17632/f5mmsp8mmj.1
title: NMN mitigates high-altitude hypoxia-induced cognitive impairment by inhibiting microglial ferroptosis. Xu et al.

description: The Upated original data material for this manuscript.
DOI: 10.17632/tkpnnc23k8
title: Bulk transcriptomics of peripheral blood mononuclear cells of childhood-onset SLE patients and healthy controls
DOI: 10.17632/tkpnnc23k8.1
title: Bulk transcriptomics of peripheral blood mononuclear cells of childhood-onset SLE patients and healthy controls
DOI: 10.17632/fwsw46ktyp
title: Serum proteomics (Olink) data of childhood-onset SLE patients and healthy controls
DOI: 10.17632/fwsw46ktyp.1
title: Serum proteomics (Olink) data of childhood-onset SLE patients and healthy controls
DOI: 10.17632/vvbgztc2n2
title: Diagnosing Fourth-Grade Students’ Misconceptions of Matter and Its Properties: An Integrated IRT And Latent Class Analysis Using A Four-Tier Diagnostic Test

description: Diagnosing Fourth-Grade Students’ Misconceptions of Matter and Its Properties: An Integrated IRT And Latent Class Analysis Using A Four-Tier Diagnostic Test
DOI: 10.17632/vvbgztc2n2.1
title: Diagnosing Fourth-Grade Students’ Misconceptions of Matter and Its Properties: An Integrated IRT And Latent Class Analysis Using A Four-Tier Diagnostic Test

description: Diagnosing Fourth-Grade Students’ Misconceptions of Matter and Its Properties: An Integrated IRT And Latent Class Analysis Using A Four-Tier Diagnostic Test
DOI: 10.17632/4y7cjz7jyg
title: Custom 1×1M Agilent microarray designed from E. curvula floral transcriptomes
DOI: 10.17632/4y7cjz7jyg.1
title: Custom 1×1M Agilent microarray designed from E. curvula floral transcriptomes
DOI: 10.15468/dl.yg9s79
title: Occurrence Download

description: A dataset containing 1165 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Celastrina lavendularis"
 ]
}

 The dataset includes 1165 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002130-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/zhg537mxjx
title: Supplementary material IJPara25_482

description: Transmission trial
DOI: 10.17632/zhg537mxjx.1
title: Supplementary material IJPara25_482

description: Transmission trial
DOI: 10.5281/zenodo.18432078
title: spatial_indicators_full_agg_csquare_grid
DOI: 10.5281/zenodo.18432079
title: spatial_indicators_full_agg_csquare_grid
DOI: 10.5281/zenodo.18406872
title: UV-Vis and Fluorescence Spectroscopy Data for the Interaction of Naphtho[2,3-b]indolizine-6,11-dione Derivatives with Putrescine

description: Biogenic amines (BAs) pose a significant threat to food safety and can cause adverse health effects. The development of innovative sensing materials for the optical detection of BAs is crucial for monitoring food quality. This dataset contains raw spectral data obtained from UV-Vis absorption and fluorescence emission spectra for five naphtho[2,3-b]indolizine-6,11-dione derivatives. The data characterize the optical response of these fluorophores to the sequential addition of putrescine (PUT).

This work has been supported by research and development grant No RTU-PA-2024/1-0028 under the EU Recovery and Resilience Facility funded project No. 5.2.1.1.i.0/2/24/I/CFLA/003 “Implementation of consolidation and management changes at Riga Technical University, Liepaja University, Rezekne Academy of Technology, Latvian Maritime Academy and Liepaja Maritime College for the progress towards excellence in higher education, science, and innovation”.
DOI: 10.5281/zenodo.18406873
title: UV-Vis and Fluorescence Spectroscopy Data for the Interaction of Naphtho[2,3-b]indolizine-6,11-dione Derivatives with Putrescine

description: Biogenic amines (BAs) pose a significant threat to food safety and can cause adverse health effects. The development of innovative sensing materials for the optical detection of BAs is crucial for monitoring food quality. This dataset contains raw spectral data obtained from UV-Vis absorption and fluorescence emission spectra for five naphtho[2,3-b]indolizine-6,11-dione derivatives. The data characterize the optical response of these fluorophores to the sequential addition of putrescine (PUT).

This work has been supported by research and development grant No RTU-PA-2024/1-0028 under the EU Recovery and Resilience Facility funded project No. 5.2.1.1.i.0/2/24/I/CFLA/003 “Implementation of consolidation and management changes at Riga Technical University, Liepaja University, Rezekne Academy of Technology, Latvian Maritime Academy and Liepaja Maritime College for the progress towards excellence in higher education, science, and innovation”.
DOI: 10.15468/dl.z5z7s8
title: Occurrence Download

description: A dataset containing 485 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Saussurea medusa"
 ]
}

 The dataset includes 485 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002131-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/t6scvp
title: Common bird monitoring scheme in Bulgaria

description: The Common bird monitoring scheme is developed by the Bulgarian Society for the Protection of Birds. The data are used to produce trends of common birds in the country which are published in nine yearly reports. These reports contain not only individual species trends but also habitat indices like the Farmland bird index and Forest Bird Index. The first year of publication is 2007 which contains the first assessment of the species trends for the period 2005-2007.Data are submitted annually to the Pan European Common Bird Monitoring Scheme administration to produce European wide indices and species trends. These trends and indices are delivered to the European Commission and Eurostat for decision-making.The current data set presents data for each individual survey plot visited in the period mentioned below.
DOI: 10.5281/zenodo.18432004
title: Supplementary Data for: Transient Aggregation-Prone States in Disordered Proteins as Therapeutic Targets: The Amyloid-β Case

description: This repository contains the complete computational dataset supporting the manuscript "Transient Aggregation-Prone States in Disordered Proteins as Therapeutic Targets: The Amyloid-β Case". 

The dataset enables full reproduction of the computational workflow, including Temperature Replica Exchange Molecular Dynamics (T-REMD) simulations, HADDOCK protein-protein docking, and subsequent analysis used to identify and characterize aggregation-prone conformational states of the Aβ42 peptide.

Contents

1. structures/- starting_conformations_TREMD/: 72 initial Aβ42 conformations for T-REMD initialization (.gro format)- representative_clusters_TREMD/: Representative cluster structures from T-REMD simulations using OPLS and a99SB-UCB force fields (.xtc format)- aggregation_prone_conformations/: Aβ42 monomers classified as aggregation-prone (.pdb format)- non_aggregation_prone_conformations/: Aβ42 monomers classified as non-aggregation-prone (.pdb format)

2. parameters/- mdp_files_TREMD/: GROMACS molecular dynamics parameter files and generation scripts for all 72 T-REMD replicas- HADDOCK_homodimer_docking/: Complete HADDOCK 2.4 input files for Aβ-Aβ homodimer docking- HADDOCK_DNAJB6_docking/: Complete HADDOCK 2.4 input files for Aβ-DNAJB6 docking validation

3. processed_data/- correlation_homodimer_docking/: Correlation analysis between HADDOCK scores and structural descriptors for different time windows (600-800 ns and 800-1000 ns)- correlation_DNAJB6/: Correlation analysis between Aβ-Aβ and Aβ-DNAJB6 HADDOCK scores

4. analysis_scripts/- clustering_analysis.sh: GROMOS clustering of MD trajectories- calculate_chemical_shifts.tcl: VMD/SPARTA+ script for NMR chemical shift calculations- calculate_jcoupling.tcl: VMD script for ³JHNHα coupling constant calculations- pearson_correlation_descriptors.py: Correlation analysis between HADDOCK scores and structural descriptors- pearson_correlation_dnajb6.py: Analysis of Aβ-Aβ vs Aβ-DNAJB6 binding correlation

Software Requirements

- GROMACS 2022.4 (or compatible)- HADDOCK 2.4- VMD 1.9.3 (or compatible)- SPARTA+ 2.88 (or later)- Python 3 with standard scientific libraries

Usage

Complete documentation, including detailed usage instructions for all scripts and reproduction protocols, is provided in the README.md file included in this repository.

Contact

For questions regarding this dataset, please contact: luca.bellucci@nano.cnr.it, margherita.bini@nano.cnr.it
DOI: 10.5281/zenodo.18432003
title: Supplementary Data for: Transient Aggregation-Prone States in Disordered Proteins as Therapeutic Targets: The Amyloid-β Case

description: This repository contains the complete computational dataset supporting the manuscript "Transient Aggregation-Prone States in Disordered Proteins as Therapeutic Targets: The Amyloid-β Case". 

The dataset enables full reproduction of the computational workflow, including Temperature Replica Exchange Molecular Dynamics (T-REMD) simulations, HADDOCK protein-protein docking, and subsequent analysis used to identify and characterize aggregation-prone conformational states of the Aβ42 peptide.

Contents

1. structures/- starting_conformations_TREMD/: 72 initial Aβ42 conformations for T-REMD initialization (.gro format)- representative_clusters_TREMD/: Representative cluster structures from T-REMD simulations using OPLS and a99SB-UCB force fields (.xtc format)- aggregation_prone_conformations/: Aβ42 monomers classified as aggregation-prone (.pdb format)- non_aggregation_prone_conformations/: Aβ42 monomers classified as non-aggregation-prone (.pdb format)

2. parameters/- mdp_files_TREMD/: GROMACS molecular dynamics parameter files and generation scripts for all 72 T-REMD replicas- HADDOCK_homodimer_docking/: Complete HADDOCK 2.4 input files for Aβ-Aβ homodimer docking- HADDOCK_DNAJB6_docking/: Complete HADDOCK 2.4 input files for Aβ-DNAJB6 docking validation

3. processed_data/- correlation_homodimer_docking/: Correlation analysis between HADDOCK scores and structural descriptors for different time windows (600-800 ns and 800-1000 ns)- correlation_DNAJB6/: Correlation analysis between Aβ-Aβ and Aβ-DNAJB6 HADDOCK scores

4. analysis_scripts/- clustering_analysis.sh: GROMOS clustering of MD trajectories- calculate_chemical_shifts.tcl: VMD/SPARTA+ script for NMR chemical shift calculations- calculate_jcoupling.tcl: VMD script for ³JHNHα coupling constant calculations- pearson_correlation_descriptors.py: Correlation analysis between HADDOCK scores and structural descriptors- pearson_correlation_dnajb6.py: Analysis of Aβ-Aβ vs Aβ-DNAJB6 binding correlation

Software Requirements

- GROMACS 2022.4 (or compatible)- HADDOCK 2.4- VMD 1.9.3 (or compatible)- SPARTA+ 2.88 (or later)- Python 3 with standard scientific libraries

Usage

Complete documentation, including detailed usage instructions for all scripts and reproduction protocols, is provided in the README.md file included in this repository.

Contact

For questions regarding this dataset, please contact: luca.bellucci@nano.cnr.it, margherita.bini@nano.cnr.it
DOI: 10.5281/zenodo.18432443
title: NUTQIY KONTEKSTDA POLIFUNKSIONAL PREDLOGLARNING O'ZGARISHI VA SHUNGA MOS BIRLIKLAR BILAN ALOQASI

description: Ushbu tezisda o‘zbek tilidagi  ko‘makchilarning (masalan, “bilan”, “uchun”, “dan” kabi) nutqiy kontekstda qanday transformatsiyaga uchrayotgani va ularga vazifadosh bo‘lgan til birliklari (sinonimik iboralar, bog‘lovchilar, otlar bilan birikmalar) bilan qanday o‘zaro bog‘lanishi o‘rganiladi. Predloglarning statik emas, balki dinamik tabiati – ya’ni kontekstga qarab ma’no o‘zgarishi, metaforik kengayishi va almashinishi – asosiy e’tibor markazida. Tadqiqot o‘zbek tilini asos qilib olib, ingliz (“with”, “for”, “from”) va rus (“s”, “dlya”, “iz”) tillaridagi o‘xshash predloglar bilan solishtirma tahlil qiladi. Natijalar shuni ko‘rsatadiki, nutqiy jarayonda predloglar tez-tez o‘zgarib, tilning moslashuvchanligi va iqtisodiyotini ta’minlaydi, ammo bu chet tillarini o‘rganuvchilar uchun qiyinchilik tug‘diradi. Ushbu yondashuv tilning pragmatik va semantik jihatlarini yoritishga, shuningdek, korpus tilshunosligi asosida amaliy misollar orqali tilshunoslikdagi mavjud bo‘shliqlarni to‘ldirishga qaratilgan.
DOI: 10.5281/zenodo.18432444
title: NUTQIY KONTEKSTDA POLIFUNKSIONAL PREDLOGLARNING O'ZGARISHI VA SHUNGA MOS BIRLIKLAR BILAN ALOQASI

description: Ushbu tezisda o‘zbek tilidagi  ko‘makchilarning (masalan, “bilan”, “uchun”, “dan” kabi) nutqiy kontekstda qanday transformatsiyaga uchrayotgani va ularga vazifadosh bo‘lgan til birliklari (sinonimik iboralar, bog‘lovchilar, otlar bilan birikmalar) bilan qanday o‘zaro bog‘lanishi o‘rganiladi. Predloglarning statik emas, balki dinamik tabiati – ya’ni kontekstga qarab ma’no o‘zgarishi, metaforik kengayishi va almashinishi – asosiy e’tibor markazida. Tadqiqot o‘zbek tilini asos qilib olib, ingliz (“with”, “for”, “from”) va rus (“s”, “dlya”, “iz”) tillaridagi o‘xshash predloglar bilan solishtirma tahlil qiladi. Natijalar shuni ko‘rsatadiki, nutqiy jarayonda predloglar tez-tez o‘zgarib, tilning moslashuvchanligi va iqtisodiyotini ta’minlaydi, ammo bu chet tillarini o‘rganuvchilar uchun qiyinchilik tug‘diradi. Ushbu yondashuv tilning pragmatik va semantik jihatlarini yoritishga, shuningdek, korpus tilshunosligi asosida amaliy misollar orqali tilshunoslikdagi mavjud bo‘shliqlarni to‘ldirishga qaratilgan.
DOI: 10.15468/dl.ezgrx7
title: Occurrence Download

description: A dataset containing 912 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-74.02968 6.51293,-73.86757 6.51293,-73.86757 6.66822,-74.02968 6.66822,-74.02968 6.51293))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 912 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002132-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jmmf76
title: Occurrence Download

description: A dataset containing 23633 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Europe",
 "Country is Portugal",
 "TaxonKey is Phaeophyceae"
 ]
}

 The dataset includes 23633 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002133-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cbby97
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sonneratia lanceolata",
 "HasCoordinate is true",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2010",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 {
 "not" : {
 "HasGeospatialIssue" : [
 "is true"
 ]
 }
 }
 ]
}

 The dataset includes 27 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002134-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18432126
title: 3H magnetic structure revisited: Insights from Patterson function analysis

description: The radial Patterson magnetization density of tritium has been reconstructed from experimental form factors.
DOI: 10.5281/zenodo.18431765
title: spatial_indicators_full_agg_FT_csquare_grid
DOI: 10.35090/gatech/80593
title: Data for Observations of the Gas Phase Composition of the 2024 BioLab Industrial Plume in the Atlanta Metropolitan Area: Conyers, GA
DOI: 10.15468/dl.dq2hfh
title: Occurrence Download

description: A dataset containing 1006 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Crotalus willardi"
 ]
}

 The dataset includes 1006 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002135-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.