cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29002604
title: Supplementary Material for: Preclinical evaluation of 99mTc-labeled LHRH analog as cancer receptor imaging.

description: Introduction: Breast cancer is the main cause of cancer-related mortality in women in the developed world. In particular, receptors of Luteinizing Hormone-Releasing Hormone (LHRH or GnRH) are overexpressed in this malignant disease. The aim of this study was to develop a new molecular probe [99mTc]Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/Nicotinic Acid (NA) as a novel molecular imaging agent for breast cancer.
Methods: HYNIC-GSG-LHRH(D-Lys6) was acquired and radiolabeled with [99mTc]Tc. Radiochemical purity and stability under different conditions were evaluated by Instant thin-layer chromatography (ITLC) and High-Performance Liquid Chromatography (HPLC). Lipophilicity was determined by the partition coefficient test. In vitro cell binding studies were performed in different human and mice breast cancer cell lines (MDA-MB-231, MDA-MB-435, MCF-7, BT474 and 4T1) as well as in normal murine fibroblasts (NIH-3T3) and CHO-K1 as a negative control. Biodistribution studies were performed in normal Balb/c mice and 4T1 tumor-bearing Balb/c mice up to 6 h post-injection (p.i.). SPECT/CT images were performed in 4T1 tumor-bearing Balb/c mice up to 5 h p.i. 
Results: [99mTc]Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/NA complex was labeled with a high radiochemical purity (&gt;98%) and remained stable for up to 4 h. It exhibited good hydrophilicity (Log P = - 2.82± 0.04) and also demonstrated significant and specific binding across all evaluated breast cancer cell lines. Biodistributions studies showed a high renal clearance and low nonspecific binding (&lt;2% Act/g) in most organs, as well as appreciable tumor uptake (5.8 ± 0.5 %ID/g 1 h p.i.) and high tumor-to-muscle ratio (maximum of 30.5 ± 11.2 at 1 h p.i.). SPECT/CT imaging of 4T1-tumor bearing Balb/c mice revealed results consistent with the biodistribution studies, showing a tumor-to-non-tumor ratio of greater than 3.5 at all evaluated times points. In vivo blocking studies confirmed specificity for the LHRH receptor.
Conclusions: [99mTc]Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/NA complex has shown significant potential for in vivo visualization of LHRH receptors expression in breast cancer.
DOI: 10.6084/m9.figshare.29002604.v1
title: Supplementary Material for: Preclinical evaluation of 99mTc-labeled LHRH analog as cancer receptor imaging.

description: Introduction: Breast cancer is the main cause of cancer-related mortality in women in the developed world. In particular, receptors of Luteinizing Hormone-Releasing Hormone (LHRH or GnRH) are overexpressed in this malignant disease. The aim of this study was to develop a new molecular probe [99mTc]Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/Nicotinic Acid (NA) as a novel molecular imaging agent for breast cancer.
Methods: HYNIC-GSG-LHRH(D-Lys6) was acquired and radiolabeled with [99mTc]Tc. Radiochemical purity and stability under different conditions were evaluated by Instant thin-layer chromatography (ITLC) and High-Performance Liquid Chromatography (HPLC). Lipophilicity was determined by the partition coefficient test. In vitro cell binding studies were performed in different human and mice breast cancer cell lines (MDA-MB-231, MDA-MB-435, MCF-7, BT474 and 4T1) as well as in normal murine fibroblasts (NIH-3T3) and CHO-K1 as a negative control. Biodistribution studies were performed in normal Balb/c mice and 4T1 tumor-bearing Balb/c mice up to 6 h post-injection (p.i.). SPECT/CT images were performed in 4T1 tumor-bearing Balb/c mice up to 5 h p.i. 
Results: [99mTc]Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/NA complex was labeled with a high radiochemical purity (&gt;98%) and remained stable for up to 4 h. It exhibited good hydrophilicity (Log P = - 2.82± 0.04) and also demonstrated significant and specific binding across all evaluated breast cancer cell lines. Biodistributions studies showed a high renal clearance and low nonspecific binding (&lt;2% Act/g) in most organs, as well as appreciable tumor uptake (5.8 ± 0.5 %ID/g 1 h p.i.) and high tumor-to-muscle ratio (maximum of 30.5 ± 11.2 at 1 h p.i.). SPECT/CT imaging of 4T1-tumor bearing Balb/c mice revealed results consistent with the biodistribution studies, showing a tumor-to-non-tumor ratio of greater than 3.5 at all evaluated times points. In vivo blocking studies confirmed specificity for the LHRH receptor.
Conclusions: [99mTc]Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/NA complex has shown significant potential for in vivo visualization of LHRH receptors expression in breast cancer.
DOI: 10.21233/418f-w656
title: LDDsite3014 water chemistry dataset

description: Raw data for the LDDsite3014 water chemistry dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.29002610
title: Supplementary Material for: Post-pancreatitis splenic artery pseudoaneurysm as a luring danger – a case report

description: INTRODUCTION
Splenic artery aneurysm (SAA) is a rare but potentially life-threatening condition. SAA can occur following an acute or chronic pancreatitis as a pseudoaneurysm, iatrogenic (post pancreatic/ splenic surgery) or post-traumatic. If symptomatic it needs to be treated urgently as it has a high risk of rupture
CASE PRESENTATION
Here is a case where a ruptured aneurysm presented in an unusual manner. First, as an acute abdomen and, second, delayed, as hemorrhagic shock. Only emergency laparotomy and splenectomy saved the patient`s life. 
CONCLUSION
If a splenic artery pseudoaneurysm is detected on CT scan, there is an increased risk of rupture irrespective of the size and the patient that should be pro-actively managed. Concomitant abdominal findings and diseases can delay diagnosis and underestimate the risk.
DOI: 10.6084/m9.figshare.29002613
title: Supplementary Material for: THE CONCEPT OF “CONVERSE THERAPEUTIC HIERARCHY” FOR PATIENTS WITH HEPATOCELLULAR CARCINOMA

description: Background. The clinical complexity of patients with hepatocellular carcinoma (HCC), the availability of multiple therapeutic options, and clinical therapeutic intents could make it challenging to identify an unequivocal limit between conversion, downstaging/downsizing, and neoadjuvant therapies and curative or palliative intent treatments and to dimension the most proper sequential therapeutic strategy for each patient. 
Summary. The concept of converse therapeutic hierarchy could rationally embrace all the different sequential treatment options (e.g., from surgery to systemic therapy) and the different therapeutic clinical intents (e.g., curative, neoadjuvant, downstaging/downsizing, conversion, and palliative), sharing the common goal of converting the patient with HCC from a less to a more favourable condition to improve the chance (higher applicability – conversion or downstaging intent) or the effectiveness (better postoperative outcome – neoadjuvant intent) of “intent-to-cure treatments”. This narrative review aims to introduce and explain the umbrella concept of the converse therapeutic hierarchy as a valuable framework for everyday clinical practice, enabling clinicians to better define ideal candidates and good responders for each sequential strategy. 
Furthermore, the converse therapeutic hierarchy concept represents a flexible container that should be continuously filled with new scientific evidence to build different sequential treatment strategies in the multidisciplinary and multi-step management of patients with HCC.
An operative and pragmatic definition of the various sequential treatment strategies, based on the initial probability of intent to cure therapy for patients with HCC, has also been proposed. This probability varies from very high to low. It is related to the initial treatment choice and the multiparametric patient evaluation (e.g., patient’s fitness, tumour features, liver function, and technical aspects) done by an expert multidisciplinary tumour board.
Key messages. The converse therapeutic hierarchy concept represents a valuable and pragmatic framework for everyday clinical practice. It also serves as a flexible container that must be filled with new high-quality evidence and expert consensus to better define the clinical boundaries between the different HCC sequential treatment strategies (e.g., neoadjuvant, downstaging/downsizing, and conversion).
DOI: 10.6084/m9.figshare.29002613.v1
title: Supplementary Material for: THE CONCEPT OF “CONVERSE THERAPEUTIC HIERARCHY” FOR PATIENTS WITH HEPATOCELLULAR CARCINOMA

description: Background. The clinical complexity of patients with hepatocellular carcinoma (HCC), the availability of multiple therapeutic options, and clinical therapeutic intents could make it challenging to identify an unequivocal limit between conversion, downstaging/downsizing, and neoadjuvant therapies and curative or palliative intent treatments and to dimension the most proper sequential therapeutic strategy for each patient. 
Summary. The concept of converse therapeutic hierarchy could rationally embrace all the different sequential treatment options (e.g., from surgery to systemic therapy) and the different therapeutic clinical intents (e.g., curative, neoadjuvant, downstaging/downsizing, conversion, and palliative), sharing the common goal of converting the patient with HCC from a less to a more favourable condition to improve the chance (higher applicability – conversion or downstaging intent) or the effectiveness (better postoperative outcome – neoadjuvant intent) of “intent-to-cure treatments”. This narrative review aims to introduce and explain the umbrella concept of the converse therapeutic hierarchy as a valuable framework for everyday clinical practice, enabling clinicians to better define ideal candidates and good responders for each sequential strategy. 
Furthermore, the converse therapeutic hierarchy concept represents a flexible container that should be continuously filled with new scientific evidence to build different sequential treatment strategies in the multidisciplinary and multi-step management of patients with HCC.
An operative and pragmatic definition of the various sequential treatment strategies, based on the initial probability of intent to cure therapy for patients with HCC, has also been proposed. This probability varies from very high to low. It is related to the initial treatment choice and the multiparametric patient evaluation (e.g., patient’s fitness, tumour features, liver function, and technical aspects) done by an expert multidisciplinary tumour board.
Key messages. The converse therapeutic hierarchy concept represents a valuable and pragmatic framework for everyday clinical practice. It also serves as a flexible container that must be filled with new high-quality evidence and expert consensus to better define the clinical boundaries between the different HCC sequential treatment strategies (e.g., neoadjuvant, downstaging/downsizing, and conversion).
DOI: 10.21233/n3pt-yb53
title: Ice Lake diatom dataset

description: Raw data for the Ice Lake diatom dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/2wz6-5x32
title: Millhurst Pond diatom surface sample dataset

description: Raw data for the Millhurst Pond diatom surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/7rpf-g228
title: Gull Lake diatom surface sample dataset

description: Raw data for the Gull Lake diatom surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/jyq1-3a40
title: Wawig Lake water chemistry dataset

description: Raw data for the Wawig Lake water chemistry dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/82kh-v834
title: LDDsite3939 ostracode surface sample dataset

description: Raw data for the LDDsite3939 ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/e93b-2x61
title: East Ujimqin Banner ostracode surface sample dataset

description: Raw data for the East Ujimqin Banner ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/6pxv-cd07
title: Lake Parker diatom bottom sample dataset

description: Raw data for the Lake Parker diatom bottom sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.29002592
title: 4_S23_3641_A4_2_study_v1_b1dcd489-a2c3-4355-b6c7-42e61ad47e55_2023-04-04_21-51-44-090_All.zip

description: renal cell carcinoma
DOI: 10.21233/9ch1-hd88
title: Pretty Lake diatom surface sample dataset

description: Raw data for the Pretty Lake diatom surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/tebr-6f64
title: Danzhou ostracode surface sample dataset

description: Raw data for the Danzhou ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/kn8f-c855
title: Pipestone Lake ostracode surface sample dataset

description: Raw data for the Pipestone Lake ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/q755-j170
title: SB-7, Seven Oaks Road pollen surface sample dataset

description: Raw data for the SB-7, Seven Oaks Road pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/k7d2-p874
title: LRRB79 pollen surface sample dataset

description: Raw data for the LRRB79 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/z4a0-cx95
title: Long Pond 256 diatom bottom sample dataset

description: Raw data for the Long Pond 256 diatom bottom sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/5x7c-9q17
title: Bowling Alley Site [34KA131] macroinvertebrate dataset

description: Raw data for the Bowling Alley Site [34KA131] macroinvertebrate dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/6n8k-5r50
title: Green Bay CBP pollen surface sample dataset

description: Raw data for the Green Bay CBP pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/vxva-da44
title: Lake Tai ostracode surface sample dataset

description: Raw data for the Lake Tai ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/4k4q-h361
title: ABD49 pollen surface sample dataset

description: Raw data for the ABD49 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.5281/zenodo.15377983
title: ГОРМОНАЛЬНАЯ РЕГУЛЯЦИЯ РОСТА И ВЫПАДЕНИЯ ВОЛОС: ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ И ИХ ЗНАЧЕНИЕ
DOI: 10.5281/zenodo.15377984
title: ГОРМОНАЛЬНАЯ РЕГУЛЯЦИЯ РОСТА И ВЫПАДЕНИЯ ВОЛОС: ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ И ИХ ЗНАЧЕНИЕ
DOI: 10.21233/nstj-xh83
title: Gardners Pond diatom surface sample dataset

description: Raw data for the Gardners Pond diatom surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/251a-x132
title: Old Crow Basin Locality CRH-11-1 [MkVl-9A] vertebrate fauna dataset

description: Raw data for the Old Crow Basin Locality CRH-11-1 [MkVl-9A] vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/80tj-t891
title: COMO7 pollen surface sample dataset

description: Raw data for the COMO7 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/sp6k-1f61
title: Grimes [23RI115] vertebrate fauna dataset

description: Raw data for the Grimes [23RI115] vertebrate fauna dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/ya1g-7q20
title: Clearwater Lake diatom dataset

description: Raw data for the Clearwater Lake diatom dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/7a54-3t89
title: Eoum-Ri ostracode surface sample dataset

description: Raw data for the Eoum-Ri ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/q031-m159
title: ONTSU 96 pollen surface sample dataset

description: Raw data for the ONTSU 96 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/17kx-h882
title: Railway testate amoebae surface sample dataset

description: Raw data for the Railway testate amoebae surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.15151/esrf-es-2015894929
title: Munich Crystallography BAG

description: The diverse groups of the Munich Crystallography BAG study a far range of subjects, reaching from structural aspects of fundamental cellular processes - such
as RNA processing, protein folding and degradation, DNA repair, chromatin remodelling, enzymes - to the design of foldamers. The research groups are located
at the LMU and TUM universities in Munich, at the Max-Planck-Institute of Biochemistry, Martinsried, and the Helmholtz Center, Neuherberg. Out-groups are
located at the universities in Darmstadt and Ulm, Germany. The research groups use X-ray crystallography, single-particle cryo-EM, SAXS, NMR and HDX and
XL-MS mass-spectrometry for structural studies.