cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17026/dans-2x5-cngv
title: Data belonging to: "Cross-resistance between Platinum-based Chemotherapy and PARP Inhibitors in Castration-Resistant Prostate Cancer"

description: These data support the findings described in "Cross-resistance between Platinum-based Chemotherapy and PARP Inhibitors in Castration-Resistant Prostate Cancer" by Slootbeek et al. All data traceable to patients (eg. Study ID, date of birth) is excluded from the dataset.The dataset contains response data of 28 metastatic castration-resistant prostate cancer patients who recieved both a platinum-based chemotherapy and a PARP inhibitor. For conclusions and interpretations, please see the paper.
DOI: 10.17026/dans-xaw-36b2
title: Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

description: Molecular dynamics (MD) trajectories for Rev1 in complex with different incoming nucleotides dATP, dGTP, dTTP and rCTP. MD simulations were performed using AMBER package (ff14SB force-field) with explicit solvent and counter-ions. The durations of each trajectory is 1 microsecond. 1,000 snapshots each separated by 1 nanosecond are provided here in PDB format. The water molecules and counter-ions have been removed from these PDB frames. These files can be viewed using a biomolecular visualization software, such as PyMOL.
DOI: 10.17026/dans-z6z-ctye
title: The effectiveness of an e-health intervention with expert patient support in individuals with an eating disorder : A randomized controlled trial

description: The present study was a RCT comparing 4 conditions: 1) Internet-based intervention ‘Featback’, 2) online support froman expert patient, 3) Featback supplemented with online support from an expert patient, and 4) a waiting list control condition. This study had two aims: 1) To investigate the effectiveness and cost-effectiveness of 8 weeks of Featback, in comparison to Featback with online support from an expert patient, online support from an expert patient without Featback, and a waiting list control condition. In total, 355 participants enrolled in the study, 43% of which indicated never to have received treatment for their eating disorder, while the average duration of the eating disorder across the sample was more than 10 years. Study dropout rates were acceptable, with the respective number of participants completing assessments at baseline, post intervention, and 3, 6, 9 and 12 month follow up being 355 (100%; T0), 280 (79%; T1), 252 (71%; T2), 244 (69%; T3), 233 (66%; T4) en 242 (68%; T5). Featback only, Featback plus online expert-patient support and online expert-patient support only were effective in reducing eating disorder symptoms after eight weeks compared to a waiting list control condition. On the long term, the difference between the participants allocated to the waiting list control condition and the other conditions disappeared, indicating no long-term differences between the conditions regarding eating disorder symptoms. No significant differences between the conditions were found regarding QALYs, health care costs and societal costs. Nonsignificant differences in QALYs were in favor of the Featback conditions and the lowest societal costs per participant were observed in the Featback only condition (€16,741) while the highest costs were seen in the care-as-usual condition (€28,479). The Featback only condition had thehighest probability of being efficient compared to the alternatives for all acceptable willingness-to-pay values.
DOI: 10.17026/dans-zr3-eutj
title: Extended list of enriched GO terms and local clusters based on significantly upregulated genes in adult CMM knockdowns in the thesis by Heim 2022

description: This file contains a table with all enriched GO terms and local clusters based on significantly upregulated genes in adult CMM knockdowns according to RNAseq of multiple samples from brain area CMM in female zebra finches that received a lentiviral knockdown of FoxP1 either as juveniles or as adults.
DOI: 10.17026/dans-xn6-pjm8
title: The Bracon brevicornis genome, supporting data

description: In presenting the Bracon brevicornis genome, supporting information is made available. The material available in this database entry are as follows:1. Contamination scaffolds from decontamination process (note, identified as being neither the carrier DNA of tomato, nor belonging to the group Arthropoda in a BlobTools analysis. For more details, refer to source manuscript.2. Two sets of pseudohaplotype FASTA files, generated from decontaminated B. brevicornis reads and output from Supernova assembler
DOI: 10.17026/dans-z5z-zec9
title: The Nesidiocoris tenuis genome manuscript supporting data

description: In presenting the first mirid genome, Nesidiocoris tenuis, several supporting information is made available. Following the main supplemetary material document (link), the contents are in this database:S1.2. Flow cytometry data for N. tenuisS1.3. Decontamination and potential LGT indentificationS1.4. Gene list (UniProtKB list) and DAVID ReportsS1.5. Full protein setS1.7. Poolseq results in full
DOI: 10.17026/dans-xh8-gh92
title: Biodiversity recovery of Neotropical secondary forests

description: Data on tree biodiversity recovery during secondary succession across the Neotropics.
DOI: 10.17026/dans-23w-a9tn
title: The Trichogramma brassicae genome, supporting data

description: In presenting the Trichogramma brassicae genome, supporting information is made available. Following the main supplemetary material document, the contents in this database entry are as follows:S1.2. Contaminated Wolbachia scaffolds from assembly v3.0 (Backbone_1176.fa and Backbone_1392.fa)S1.3. DAVID input gene listS1.5. Full Trichogramma brassicae protein set from annotation
DOI: 10.17026/dans-zq6-wp2v
title: Bijdrage van het Cultureel Interview door POH-GGZ in diagnose en behandeling van niet-westerse patiënten in de huisartspraktijk

description: Het doel van het project was het krijgen van inzicht in de bijdrage van het Cultureel Interview (CI) door POH-GGZ in diagnose en behandeling van niet-westerse patiënten in de huisartsenpraktijk. Angst, depressie en somatisch onvoldoende verklaarde lichamelijke klachten (SOLK) komen veel voor bij niet-westerse migranten in de huisartsenpraktijk. Klachten worden door deze groep anders beleefd en gepresenteerd dan door autochtonen. Dit bemoeilijkt de diagnosestelling en behandeling. Verkennen van de invloed van culturele factoren op de klachtbeleving en relatie met zorgverleners kan de zorg aan niet-westerse migranten mogelijk verbeteren. Hiertoe hebben we het ‘Culturele Interview’ (gebaseerd op het Cultural Formulation Interview in de DSM-5) doorontwikkeld voor toepassing door de POH-GGZ en getoetst in de huisartsenpraktijk.Na getraind te zijn, namen zeven POH-GGZ| het Cultureel Interview af bij 43 patiënten van niet-westerse afkomst. We vergeleken deze groep met 22 controlepatiënten, die de gebruikelijke zorg ontvingen van niet getrainde POH-GGZ. Het betrof patiënten met een niet-Westerse achtergrond die nieuw in behandeling kwamen bij de POH-GGZ.
DOI: 10.17026/dans-zt7-kaad
title: Analyses of Electronic Medical Records Utilization in a Large Community Hospital

description: Electronic medical record utilization at NewYork-Presbyterian Brooklyn Methodist Hospital, a 651-bed tertiary care center from June 2016 to October 2016
DOI: 10.17026/dans-zg3-qvba
title: Differentially expressed genes for all subgroups examined in the thesis by Heim 2022

description: This file contains a table with all genes detected to be differentially expressed according to RNAseq of multiple samples from brain areas HVC or CMM in female zebra finches that received a lentiviral knockdown of FoxP1 either as juveniles or as adults.
DOI: 10.17026/dans-23p-7626
title: Gene set enrichment analyses data for all subgroups examined in the thesis by Heim 2022.

description: This file contains the gene set enrichment analyses data (GSEA 4.11) based on RNAseq of multiple samples from brain areas HVC or CMM in female zebra finches that received a lentiviral knockdown of FoxP1 either as juveniles or as adults.
DOI: 10.17026/dans-2bj-ks3v
title: Differentially expressed genes across all subgroups examined in the thesis by Heim 2022 that overlap with a previous study by Araujo et al. (2015)

description: This file contains a table with all genes detected to be differentially expressed in this study according to RNAseq of multiple samples from brain areas HVC or CMM in female zebra finches that received a lentiviral knockdown of FoxP1 either as juveniles or as adults and overlap with a study in mice by Araujo et al. (2015).
DOI: 10.17026/dans-27n-r6bn
title: Supplemental Data underlying the manuscript: Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

description: Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the cellular physiology of these different culture conditions by RNAseq of 14 BC cell lines cultured in both 2D and 3D conditions. All 3D BC cell cultures demonstrated increased mitochondrial metabolism and downregulated cell cycle programs. Luminal BC cells in 3D demonstrated overall limited reprogramming. 3D basal B BC cells showed increased expression of extracellular matrix (ECM) interaction genes, which coincides with an invasive phenotype not observed in other BC cells. Genes downregulated in 3D were associated with metastatic disease progression in BC patients, including cyclin dependent kinases and aurora kinases. Furthermore, the overall correlation of the cell line transcriptome to the BC patient transcriptome was increased in 3D cultures for all TNBC cell lines. To define the most optimal culture conditions to study the oncogenic pathway of interest, an open source bioinformatics strategy was established.
DOI: 10.17026/dans-2c6-4rfd
title: Samen Gezond Groot - optimalisering van de leefstijladvisering in de JGZ 0-4

description: Binnen het participatieve onderzoek Samen Gezond Groot is samen met JGZ-professionals en ouders van 4 organisaties (GGD Kennemerland, GGD Zaanstreek-Waterland, JGZ Kennemerland en JGZ Zuid-Holland West) onderzoek gedaan naar de ervaringen en tevredenheid met de huidige leefstijladvisering in de JGZ voor 0 tot 4 jarigen. Op basis hiervan zijn vier aangepaste werkwijzen/innovaties ontwikkeld om de leefstijladvisering te optimaliseren. Twee van deze aangepaste werkwijzen zijn geëvalueerd op tevredenheid en haalbaarheid.Dit onderzoek bestond uit een combinatie van kwantitatief (vragenlijsten) en kwalitatief onderzoek (interviews) met zowel JGZ professionals als ouders die met hun 0-4 jarige kind de JGZ bezoeken.
DOI: 10.17026/dans-x8k-kuxs
title: Compositional profiling of porcine tonsillar microbiota around weaning in relation to abundance of Streptococcus suis

description: Some Streptococcus suis strains are associated with post-weaning disease in piglets and are emerging zoonotic pathogens of humans. The piglet microbiota may positively or negatively influence colonisation of S. suis and invasive disease risk. To identify bacterial taxa correlated with S. suis abundance, samples from the tonsil and small intestine of piglets were collected around weaning for compositional microbiota profiling.
DOI: 10.17026/dans-xt5-ncj2
title: HANDS - Influence of visuo-proprioceptive illusion of movement and motor imagery of the wrist on EEG cortical excitability in healthy participants

description: EEG recording data of 20 healthy subjects when they feeled tendon vibration on their wrist while doing motor imagery about the wristRecording on 12 electrodes named1: 'Fz'2: 'FC1'3: 'FC2'4: 'FC5'5: 'FC6'6: 'Cz'7: 'C3'8: 'C4'9: 'T7'10: 'T8'11: 'CP1'12: 'CP2'13: 'CP5'14: 'CP6'15: 'Pz'
DOI: 10.17026/dans-2ag-f743
title: A view on critical oxygen delivery values during cardiopulmonary bypass

description: AbstractIntroduction: Low oxygen delivery during cardiopulmonary bypass is related to a range of adverse outcomes. Previous research specified certain critical oxygen delivery levels associated with acute kidney injury. However, a single universal critical oxygen delivery value is not sensible, as oxygen consumption has to be considered when determining critical delivery values. This study examined the associations between oxygen delivery, oxygen consumption and kidney function in patients undergoing cardiopulmonary bypass. Methods. Oxygen delivery, oxygen consumption and kidney function decrease were retrospectively studied in 65 adult patients. Results. Mean oxygen consumption was 56 ± 8 ml/min/m2, mean oxygen delivery was 281 ± 39 ml/min/m2. Twenty-seven patients (42%) had an oxygen delivery lower than the previously mentioned critical value of 272 ml/min/m2. None of the patients developed acute kidney injury according to RIFLE criteria. However, in 10 patients (15%) a decrease in the estimated glomerular filtration rate of more than 10% was noted, which was not associated with oxygen delivery lower than 272 ml/min/m2. Eighteen patients had a strong correlation (r &gt;0.500) between DO2 and VO2, but this was not related to low oxygen delivery. Central venous oxygen saturation (77 ± 3%), oxygen extraction ratio (21 ± 3%) and blood lactate levels at the end of surgery (1.2 ± 0.3 mmol/l) showed not to be indicative of insufficient oxygen delivery either. Conclusions. This study could not confirm an evident correlation between O2 delivery and O2 consumption or kidney function decrease, even at values below previously specified critical levels. The variability in O2 consumption however, is an indication that every patient has individual O2 needs, advocating for an individualized O2 delivery goal.
DOI: 10.17026/dans-xck-d6jq
title: Data belonging to Oram et al. Plant community flood resilience in intensively managed grasslands and the role of the plant economic spectrum.

description: These data belong to Oram et al. (2020) Plant community flood resilience in intensively managed grasslands and the role of the plant economic spectrum. Published in Journal of Applied Ecology.
DOI: 10.2909/65f095af-5225-490b-8a29-4500d4c31b8a
title: High Resolution Vegetation Phenology and Productivity: Plant Phenology Index (raster 10m) version 1 revision 1, Sep. 2021

description: This metadata refers to the Plant Phenology Index (PPI) dataset, one of the near real-time (NRT) Vegetation Index products of the pan-European High Resolution Vegetation Phenology and Productivity (HR-VPP), component of the Copernicus Land Monitoring Service (CLMS). The Plant Phenology Index (PPI) is a physically based vegetation index for improved monitoring of plant phenology, that is developed from a simplified solution to the radiative transfer equation by Jin and Eklundh (2014). PPI has a linear relationship with green leaf area index, a strong correlation with gross primary productivity, and is capable of disentangling remotely sensed plant phenology from snow seasonality. It is reported to be superior to other indices for spring phenology retrieval over the northern latitudes and for GPP estimation in African semi-arid ecosystems. Comparison of satellite-derived PPI to ground observations of plant phenology and gross primary productivity (GPP) shows strong similarity of temporal patterns over several Nordic boreal forest sites. The PPI dataset is made available as raster files with 10 x 10m resolution, in UTM/WGS84 projection corresponding to the Sentinel-2 tiling grid, for those tiles that cover the EEA38 countries and the United Kingdom and for the period from October 2016 until today, with daily updates. Each file has an associated quality indicator (QFLAG2) to assist users with the screening of clouds, shadows from clouds and topography, snow and water surfaces.
DOI: 10.17026/dans-zeh-fd4m
title: FOODSECURE Scenario Driver Database

description: The FOODSECURE Scenario Driver Database contains projections for key drivers that, in combination with storylines, describe four scenarios for the assessment of global food security. The database provides information for 19 regions that together have global coverage for the period 2010-2050.
DOI: 10.17026/dans-26a-mp4b
title: PRO-SWAP data

description: Dataset on culture-based prophylaxis in transrectal prostate biopsy
DOI: 10.17026/dans-xs9-hf76
title: Supplemental Data underlying the manuscript: Unraveling the spliceosomal control of breast cancer cell motility behavior

description: There is increasing evidence for a role of alternative splicing in the progression and metastasis of breast cancer. The role of the splicing machinery in the tumor cell migration of aggressive triple-negative breast cancer (TNBC) remains elusive. Here we systematically evaluated the role of RNA splicing in TNBC cell motility behavior. A targeted RNAi screen of all 244 major splicing factors in two highly motile TNBC cancer cell lines uncovered ten splicing factors, including CWC15, PHF5A, SF3A3, SMNDC1, SNRPA1, SNRPB2, SNRPD2, SNRPG, SRSF7 and U2AF1, that act as common migratory modulators in TNBC with limited effects on cell proliferation and survival. All of these factors were associated with aggressive breast cancer subtypes and/or metastasis-free survival in breast cancer patients. Two of the most prominent factors, SRSF7 and SMNDC1, are critical for RNA processing in association with regulating the expression of gene networks involved in cell-matrix adhesion signaling. SRSF7 resided in a large protein-protein interaction splicing complex together with PRPF4B and BUD31, and was affecting similar exon inclusion events, making this complex a candidate for drug development.
DOI: 10.17026/dans-23r-sfh8
title: Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) – MultiplexELISA data set

description: Multiplex ELISA data of immune, metabolism and hormone related molecules for 79 children included in the Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) study, an open-label trial during which children with ADHD followed a few-foods diet (FFD). Sampling was done before the FFD (t1) and after 5 weeks of FFD (t2).
DOI: 10.17026/dans-2x8-rge4
title: Supplemental Data underlying the manuscript: Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

description: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment. We performed an RNAi screen targeting 244 individual splicing factors to systematically evaluate their role in TNBC cell proliferation. We identified nine splicing factors, including SNRPD2, SNRPD3 and NHP2L1, of which depletion inhibited proliferation in two TNBC cell lines by deregulation of sister chromatid cohesion (SCC) via increased sororin intron 1 retention and down-regulation of SMC1, MAU2 and ESPL1. Protein-protein interaction analysis of SNRPD2, SNRPD3 and NHP2L1 identified that seven out of the nine identified splicing factors belong to the same spliceosome subcomplex including the novel component SUN2 that was also critical for efficient sororin splicing. Finally, sororin transcript levels highly correlate to various proliferation markers in BC patients, suggesting that deregulating sororin levels through targeting of the relevant splicing factors might be a potential strategy to treat TNBC.
DOI: 10.17026/dans-xap-jq2v
title: How are countries planning for costs of nutrition data and information systems?

description: This dataset was compiled for a review of national nutrition plans for 58 Scaling Up Nutrition (SUN) countries to better understand how countries are planning for and estimating the costs of their NDIS
DOI: 10.17026/dans-xxb-2rcu
title: Preoperative endometrial cancer risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: an ENITEC development and external validation study

description: Imputed dataset used for development of ENDORISK Bayesian network, to predict lymph node metastasis in endometrial cancer. These data were retrospectively collected from ten participating centers across Europe.These data belong to and include all variables for the statistical analyses conducted in the paper “Preoperative endometrial cancer risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: an ENITEC development and external validation study”, by Casper Reijnen and colleagues. The objective of this paper was to develop and validate a preoperative Bayesian network to predict the risk of lymph node metastasis and survival in patients surgically treated for endometrial cancer.Within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) consortium. Ten participating centers included patients treated between February 1995 and August 2013 for International Federation of Gynecology and Obstetrics (FIGO) stage I-IV endometrioid endometrial carcinoma (EEC), or non-endometrioid endometrial carcinoma (NEEC).
DOI: 10.17026/dans-xeb-u95k
title: HRCT Reference Atlas for Pulmonary Fibrosis Severity Score in Scleroderma Patients

description: Systemic sclerosis (SSc), also known as scleroderma, is a chronic, progressive connective tissue disease characterized by autoimmune phenomena, microangiopathy and fibrosis of the skin and internal organs. Pulmonary involvement by interstitial lung disease (SSc-ILD) is a significant cause of morbidity and mortality.In order to facilitate assessing the severity of ILD according to the Goh scoring system, we have made this reference atlas based on High Resolution Computed Tomography (HRCT) images.
DOI: 10.17026/dans-xhk-74m4
title: Can journal guidelines improve the reporting of antibody validation?

description: Data pertaining to the publication "Can journal guidelines improve the reporting of antibody validation?". The project investigates the quality of antibody validation information provided in 120 biomedical publications and whether the introduction of journal validation guidelines improved the quality of this information.The data covers 60 publications before introduction of guidelines, and 60 after introduction, half of which from journals with guidelines. The quality of antibody validation information was coded by one author ("Antibody validation information data set.xlsx"), with a sample checked for interrater reliability by another ("Interrater reliability data set.xlsx"). Effects of journal guidelines introduction were tested statistically with a pseudo-experimental design. (Code for the statistical package R is provided.) The data package also includes detailed explanation of how coding was performed ("Coding protocol.docx") and an explanation of these files and data labels ("Data dictionary.docx").
DOI: 10.5281/zenodo.10259296
title: Data from: Snowmobile noise alters bird vocalization patterns during winter and pre-breeding season
DOI: 10.5281/zenodo.10259297
title: Data from: Snowmobile noise alters bird vocalization patterns during winter and pre-breeding season
DOI: 10.17026/dans-xy8-mycd
title: Temperature sensitivity of freshwater denitrification and N2O emission – a meta-analysis

description: This depositited dataset contains the data and scripts underlying a meta-analysis on the temperature sensitivity of freshwater denitrification and N2O emission rates.
DOI: 10.17026/dans-2bj-7ach
title: Marketing of medicines in primary care: an analysis of direct marketing mailings and advertisements

description: In this study, we investigated the use of seven common persuasion strategies in direct marketing mailings and advertisements from pharmaceutical companies sent to general practitioners. We found that all persuasion strategies - i.e. reciprocity, consistency/commitment, social proof, liking, authority, scarcity and unity – were present in marketing materials from pharmaceutical companies along with a newly identified strategy, the use of emotional pressure, which happened to be present in one third of the materials. To this end, we analysed 68 unique marketing materials involving 37 different medicines.