cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20677016.v1
title: Electrochemical immunosensor for detection of Plasmodium vivax lactate dehydrogenase

description: BACKGROUND Malaria is a disease that affects many tropical and subtropical countries, including Brazil. The use of tests for malaria detection is one of the fundamental strategies recommended by the World Health Organization for the control and eradication of the disease. The lack of diagnostic tests leads to an increase in transmission and non-reporting cases. OBJECTIVES This work described an electrochemical immunosensor for detecting Plasmodium vivax lactate dehydrogenase antigen (Ag-PvLDH). METHODS The device has developed by immobilising egg yolk IgY antibodies (Ab-PvLDH) on a gold electrode surface using cysteamine as linker. The immunosensor fabrication was followed by differential pulse voltammetry, and contact angle measurements were performed to characterise the modified gold electrode surface. FINDINGS The results for Ag-PvLDH determination exhibit a linear response at 10-50 µg mL-1 concentration range, with a limit of detection of 455 ng mL-1. The excellent selectivity of the device was confirmed. MAIN CONCLUSIONS The developed immunosensor showed a good performance, therefore, it can be considered an alternative test to detect malaria caused by P. vivax.
DOI: 10.6084/m9.figshare.20677018
title: Financialization, accumulation, and shareholding changes in companies and corporate groups in the Brazilian health sector

description: This study aims to analyze the shareholding dimension of changes in companies and corporate groups in the Brazilian health sector from 2008 to 2017. The idea was to understand the strategies of accumulation in a context of financialization, defined as a systemic pattern of wealth in contemporary capitalism. The shareholding changes were submitted to descriptive and exploratory analysis based on different sources. We studied 58 companies from the subsectors of health plans, pharmacies, hospitals, diagnostics, pharmaceutical industry, and social organizations. Data were collected on the legal structure, ownership, and control, equity operations, and economic and patient care activities. Despite the heterogeneity of the companies and their strategies, the results point to an increase in the presence of domestic and international investors, changes in internal organization, capital, financing, and diversification of activities. The companies that stood out were actively pursuing capitalization via foreign investments, purchase and share of assets and shares, and mergers and acquisitions, accelerating the process of expansion, accumulation, and shareholding and financial appreciation. The result is an increase in capital flows and growing integration of economic and patient care structures in the Brazilian health sector with financial circuits, thereby linking peripheral intermediate companies to an expanded process of accumulation under financial dominance. The findings corroborate striking aspects of corporate dynamics in financialization that increasingly influence health systems in Brazil and the world.
DOI: 10.6084/m9.figshare.20677018.v1
title: Financialization, accumulation, and shareholding changes in companies and corporate groups in the Brazilian health sector

description: This study aims to analyze the shareholding dimension of changes in companies and corporate groups in the Brazilian health sector from 2008 to 2017. The idea was to understand the strategies of accumulation in a context of financialization, defined as a systemic pattern of wealth in contemporary capitalism. The shareholding changes were submitted to descriptive and exploratory analysis based on different sources. We studied 58 companies from the subsectors of health plans, pharmacies, hospitals, diagnostics, pharmaceutical industry, and social organizations. Data were collected on the legal structure, ownership, and control, equity operations, and economic and patient care activities. Despite the heterogeneity of the companies and their strategies, the results point to an increase in the presence of domestic and international investors, changes in internal organization, capital, financing, and diversification of activities. The companies that stood out were actively pursuing capitalization via foreign investments, purchase and share of assets and shares, and mergers and acquisitions, accelerating the process of expansion, accumulation, and shareholding and financial appreciation. The result is an increase in capital flows and growing integration of economic and patient care structures in the Brazilian health sector with financial circuits, thereby linking peripheral intermediate companies to an expanded process of accumulation under financial dominance. The findings corroborate striking aspects of corporate dynamics in financialization that increasingly influence health systems in Brazil and the world.
DOI: 10.6084/m9.figshare.20677025
title: Arbitrator’s expectations and motives regarding the expert accountant’s performance in arbitration in the light of role theory

description: ABSTRACT The paper sought to grasp the arbitrator’s expectations regarding the expert accountant’s performance in the arbitration arena in the light of role theory and the reasons for meeting these expectations or not. The study of arbitrator’s expectations has been poorly explored in the field of forensic accounting. This article helps to fill this gap by presenting expectations and motives that affect the arbitrator’s perception of the expert accountant’s service. The study is relevant because it grasps expectations from the arbitrator’s viewpoint (role transferrer) regarding the expert accountant’s performance (function recipient). Expectations are characterized by abilities and skills that may not be met during role performance due to conflicting or ambiguous reasons, simultaneous occurrence of two or more roles, or lack of clarity about the latter. The research aims to provide means for expert accountants entering arbitration and seek improvement for those already working in this scenario, reducing the gap between the arbitrator’s expectations and expert evidence production. The descriptive research has been designed as a field study and a qualitative approach to data. The research participants were 15 Brazilian arbitrators. Data collection took place through interviews and they were submitted to the content analysis method and the categorical analysis technique. The results indicate that the arbitrator’s expectations are oratory, objectivity, clarity, and sticking to the technical issue, while the reasons are inter-transferrer, inter-role conflict, overload, expert’s partiality, and lack of clarity when the arbitrator transfers the role. The practical contribution lies in providing means for expert accountants entering arbitration and seeking improvement for those already working in this scenario, reducing the gap between the arbitrator’s expectations and expert evidence production.
DOI: 10.6084/m9.figshare.20677025.v1
title: Arbitrator’s expectations and motives regarding the expert accountant’s performance in arbitration in the light of role theory

description: ABSTRACT The paper sought to grasp the arbitrator’s expectations regarding the expert accountant’s performance in the arbitration arena in the light of role theory and the reasons for meeting these expectations or not. The study of arbitrator’s expectations has been poorly explored in the field of forensic accounting. This article helps to fill this gap by presenting expectations and motives that affect the arbitrator’s perception of the expert accountant’s service. The study is relevant because it grasps expectations from the arbitrator’s viewpoint (role transferrer) regarding the expert accountant’s performance (function recipient). Expectations are characterized by abilities and skills that may not be met during role performance due to conflicting or ambiguous reasons, simultaneous occurrence of two or more roles, or lack of clarity about the latter. The research aims to provide means for expert accountants entering arbitration and seek improvement for those already working in this scenario, reducing the gap between the arbitrator’s expectations and expert evidence production. The descriptive research has been designed as a field study and a qualitative approach to data. The research participants were 15 Brazilian arbitrators. Data collection took place through interviews and they were submitted to the content analysis method and the categorical analysis technique. The results indicate that the arbitrator’s expectations are oratory, objectivity, clarity, and sticking to the technical issue, while the reasons are inter-transferrer, inter-role conflict, overload, expert’s partiality, and lack of clarity when the arbitrator transfers the role. The practical contribution lies in providing means for expert accountants entering arbitration and seeking improvement for those already working in this scenario, reducing the gap between the arbitrator’s expectations and expert evidence production.
DOI: 10.6084/m9.figshare.20677030
title: Pretreatment and Enzymatic Saccharification of Water Hyacinth, Sugarcane Bagasse, Maize Straw, and Green Coconut Shell Using an Organosolv Method with Glycerol and FeCl3

description: A method to pretreatment of biomasses using glycerol as a green solvent was developed. Optimization of organosolv pretreatment was performed using a 23 factorial design, investigating synergism among the variables particle size (from &lt; 0.85 to &gt; 2.0 mm), FeCl3 concentration (0.025-0.175 mol L-1), and temperature (160-220 °C). Although the effects of the variables differed according to the type of lignocellulose, it was nonetheless possible to find an optimal condition in common (&lt; 0.85 mm; 0.025 mol L-1; 220 °C), which was economically and environmentally sustainable, employing a small amount of catalyst. The biomasses pretreated using this combination of factors exhibited enzymatic digestibility exceeding 93% after 48 h, reflecting efficient reduction of recalcitrance as a result of high removal of hemicellulose (ca. 90%), provided by the use of FeCl3, together with substantial delignification. There was low formation of inhibitors in the hydrolysate, indicating that it could be directly fermented. The lignin removed to liquors could be easily recovered by centrifugation. Tests carried out under the optimal condition revealed that after the pretreatment the biomass could be directly used in enzymatic hydrolysis, without washing and wet. Furthermore, after simple treatment, crude glycerol was as effective as commercial glycerol.
DOI: 10.6084/m9.figshare.20677034
title: Discovery of Thiopyrimidinone Derivatives as a New Class of Human Aldose Reductase Inhibitors

description: Diabetes is a chronic metabolic disorder characterized by insufficient insulin production, the cells’ inability to use this insulin, or a combination of both, leading to secondary complications such as diabetic neuropathy and retinopathy. One way to prevent or control such complications is the use of aldose reductase (AR) inhibitors. In this work, we synthesized and tested new candidates for human AR inhibition containing a 2-thiopyrimidin-4-one heterocycle as a central ring. The fifteen derivatives were tested in vitro and their binding modes were evaluated via molecular docking simulations. AR inhibition assays showed that all synthesized compounds were able to inhibit the AR enzyme at 50 μM. From these results, seven compounds were noteworthy and had their half maximal inhibitory concentration (IC50) values estimated, ranging from 2.0 to 14.5 μM. Molecular docking simulations showed that these compounds bind specifically to the catalytic subpocket and the results indicate a good association between in vitro and in silico studies.
DOI: 10.6084/m9.figshare.20677034.v1
title: Discovery of Thiopyrimidinone Derivatives as a New Class of Human Aldose Reductase Inhibitors

description: Diabetes is a chronic metabolic disorder characterized by insufficient insulin production, the cells’ inability to use this insulin, or a combination of both, leading to secondary complications such as diabetic neuropathy and retinopathy. One way to prevent or control such complications is the use of aldose reductase (AR) inhibitors. In this work, we synthesized and tested new candidates for human AR inhibition containing a 2-thiopyrimidin-4-one heterocycle as a central ring. The fifteen derivatives were tested in vitro and their binding modes were evaluated via molecular docking simulations. AR inhibition assays showed that all synthesized compounds were able to inhibit the AR enzyme at 50 μM. From these results, seven compounds were noteworthy and had their half maximal inhibitory concentration (IC50) values estimated, ranging from 2.0 to 14.5 μM. Molecular docking simulations showed that these compounds bind specifically to the catalytic subpocket and the results indicate a good association between in vitro and in silico studies.
DOI: 10.6084/m9.figshare.20677036
title: A STOCHASTIC OPTIMIZATION MODEL FOR THE IRREGULAR KNAPSACK PROBLEM WITH UNCERTAINTY IN THE PLATE DEFECTS

description: ABSTRACT The present research deals with the two-dimensional knapsack problem by considering the cutting of irregular items from a rectangular plate with defects. While the defects are only known at the time of cutting (in the future), we need first to select which items to produce from cutting the plate. The final items cannot have any defects and the goal is to maximize the profit from cutting the plate and producing the items. We propose a two-stage stochastic optimization model that makes use of a discrete set of scenarios with the realization of the plate defects. The first-stage decisions involve selecting items for cutting and possible production. The second-stage decisions consider the positioning of items in the plate given the scenarios with defects, and then the cancellation and non-production of some selected items, if any. We also extend this model to include a measure of risk, aiming at robust solutions. We perform computational tests on instances adapted from the literature that consider three types of defects, eight scenarios, and four cases for determining each scenario’s probability. The tests evaluate the impact of uncertainties on the problem by calculating the expected value of perfect information and the value of the stochastic solution. The results indicate a percentage reduction in the profit of up to 27.7%, on average, when considering a fully risk-averse decision-maker.
DOI: 10.6084/m9.figshare.20677036.v1
title: A STOCHASTIC OPTIMIZATION MODEL FOR THE IRREGULAR KNAPSACK PROBLEM WITH UNCERTAINTY IN THE PLATE DEFECTS

description: ABSTRACT The present research deals with the two-dimensional knapsack problem by considering the cutting of irregular items from a rectangular plate with defects. While the defects are only known at the time of cutting (in the future), we need first to select which items to produce from cutting the plate. The final items cannot have any defects and the goal is to maximize the profit from cutting the plate and producing the items. We propose a two-stage stochastic optimization model that makes use of a discrete set of scenarios with the realization of the plate defects. The first-stage decisions involve selecting items for cutting and possible production. The second-stage decisions consider the positioning of items in the plate given the scenarios with defects, and then the cancellation and non-production of some selected items, if any. We also extend this model to include a measure of risk, aiming at robust solutions. We perform computational tests on instances adapted from the literature that consider three types of defects, eight scenarios, and four cases for determining each scenario’s probability. The tests evaluate the impact of uncertainties on the problem by calculating the expected value of perfect information and the value of the stochastic solution. The results indicate a percentage reduction in the profit of up to 27.7%, on average, when considering a fully risk-averse decision-maker.
DOI: 10.6084/m9.figshare.20677043.v1
title: Evaluation of the dosimetry and centralization of scout-view function in CBCT

description: Abstract This study evaluated the centralization of the region of interest (ROI) in acquisition of the CBCT images, when the freely positionable scout-view (SV) function is applied. Additionally, the dosimetry of the acquired images was assessed in the SV function alone as well as in complete tomographic image in two different fields of view (FOV) (50x50 and 78x150mm). A three-location device was created to accommodate the dosimeters and the specimens, in the right, middle and left location during image acquisition. For dose assessment, thermoluminescent dosimeters were irradiated within the FOV and analyzed in a portable reader. For ROI evaluation, three specimens of gutta-percha stick were placed on the same device and the CT scans were acquired (CBCT OP 300 Maxio device, 90kV, 13mA, 85 µm voxel size, FOV of 50X50mm), with and without the SV, in three positions (3-9, 1-7 and 5-11 o’clock), simulating different regions of the mouth. Two image evaluations were performed, an objective and subjective. There was a slight percentage increase (1.36% to 1.40%) of the radiation dose with the use of SV. The distances were significantly greater in the images acquired without SV (p &lt; 0.05). Every image obtained with SV was classified as being at the FOV’s center. In conclusion, the results demonstrated that SVs function is effective to centralize the ROI in the FOV, increasing the scan precision and avoiding repetitions due to positioning errors.
DOI: 10.6084/m9.figshare.20677043
title: Evaluation of the dosimetry and centralization of scout-view function in CBCT

description: Abstract This study evaluated the centralization of the region of interest (ROI) in acquisition of the CBCT images, when the freely positionable scout-view (SV) function is applied. Additionally, the dosimetry of the acquired images was assessed in the SV function alone as well as in complete tomographic image in two different fields of view (FOV) (50x50 and 78x150mm). A three-location device was created to accommodate the dosimeters and the specimens, in the right, middle and left location during image acquisition. For dose assessment, thermoluminescent dosimeters were irradiated within the FOV and analyzed in a portable reader. For ROI evaluation, three specimens of gutta-percha stick were placed on the same device and the CT scans were acquired (CBCT OP 300 Maxio device, 90kV, 13mA, 85 µm voxel size, FOV of 50X50mm), with and without the SV, in three positions (3-9, 1-7 and 5-11 o’clock), simulating different regions of the mouth. Two image evaluations were performed, an objective and subjective. There was a slight percentage increase (1.36% to 1.40%) of the radiation dose with the use of SV. The distances were significantly greater in the images acquired without SV (p &lt; 0.05). Every image obtained with SV was classified as being at the FOV’s center. In conclusion, the results demonstrated that SVs function is effective to centralize the ROI in the FOV, increasing the scan precision and avoiding repetitions due to positioning errors.
DOI: 10.6084/m9.figshare.20677048
title: Anti-Hyperglycemic Activities, Molecular Docking and Structure-Activity Relationships (SARs) Studies of Endiandric Acids and Kingianins from Endiandra kingiana

description: Diabetes has become a severe chronic disease worldwide with patients significantly increasing daily. Due to the side effects of insulin and oral hypoglycaemic agents employed in diabetes treatment, scientists are working hard to develop alternative approaches from natural plants that inhibit α-amylase and α-glucosidase. Consequently, by performing a phytochemical analysis on the bark of Endiandra kingiana, the present study isolated 11 cyclic polyketides. Analyses with one-dimensional and two-dimensional nuclear magnetic resonance (1D- and 2D-NMR), high-resolution electron ionization mass spectrometry (HRESIMS), and comparison with previous literature confirmed the compounds characteristics. Subsequently, the compounds were screened for in vitro α-amylase and α-glucosidase inhibiting activities. Compounds 9 and 2 exhibited potent inhibition towards α-amylase at 0.0008903 ± 0.5 and 0.02 ± 0.3 mg mL-1 of half-maximal inhibitory concentration (IC50) values, respectively. In the α-glucosidase inhibition assay, compounds 10 and 5 demonstrated good inhibition with IC50 values of 0.11 ± 0.08 and 0.14 ± 0.05 mg mL-1, respectively. The molecular docking examination demonstrated that the compounds adhered to the active sites on the C-terminal of the human pancreatic α-amylase (Protein Data Bank Identification (PDB ID): 2QV4, resolution: 1.97 Å) and maltase-glucoamylase (MGAM) (PDB ID: 3TOP, resolution: 2.88 Å), agreeing with α-amylase and α-glucosidase enzymes inhibitory reactions.
DOI: 10.6084/m9.figshare.20677048.v1
title: Anti-Hyperglycemic Activities, Molecular Docking and Structure-Activity Relationships (SARs) Studies of Endiandric Acids and Kingianins from Endiandra kingiana

description: Diabetes has become a severe chronic disease worldwide with patients significantly increasing daily. Due to the side effects of insulin and oral hypoglycaemic agents employed in diabetes treatment, scientists are working hard to develop alternative approaches from natural plants that inhibit α-amylase and α-glucosidase. Consequently, by performing a phytochemical analysis on the bark of Endiandra kingiana, the present study isolated 11 cyclic polyketides. Analyses with one-dimensional and two-dimensional nuclear magnetic resonance (1D- and 2D-NMR), high-resolution electron ionization mass spectrometry (HRESIMS), and comparison with previous literature confirmed the compounds characteristics. Subsequently, the compounds were screened for in vitro α-amylase and α-glucosidase inhibiting activities. Compounds 9 and 2 exhibited potent inhibition towards α-amylase at 0.0008903 ± 0.5 and 0.02 ± 0.3 mg mL-1 of half-maximal inhibitory concentration (IC50) values, respectively. In the α-glucosidase inhibition assay, compounds 10 and 5 demonstrated good inhibition with IC50 values of 0.11 ± 0.08 and 0.14 ± 0.05 mg mL-1, respectively. The molecular docking examination demonstrated that the compounds adhered to the active sites on the C-terminal of the human pancreatic α-amylase (Protein Data Bank Identification (PDB ID): 2QV4, resolution: 1.97 Å) and maltase-glucoamylase (MGAM) (PDB ID: 3TOP, resolution: 2.88 Å), agreeing with α-amylase and α-glucosidase enzymes inhibitory reactions.