cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21835167.v1
title: Prevalence of Streptococcus agalactiae capsular types among pregnant women in Rio de Janeiro and the impact of a capsular based vaccine

description: Abstract Streptococcus agalactiae (group B Streptococcus, GBS) remains one major neonatal pathogen, being maternal colonization a risk factor for infection development. Despite effective, the usage of antibiotics to prevent neonatal infections has limitations. The bacterial polysaccharide capsule is a virulence determinant, a target for vaccine directed to pregnant women, and also the most useful epidemiological marker of GBS infections. Capsular polysaccharides are diverse and disease severity varies according to the expressed type. Here, capsular typing of 124 GBS isolates recovered from pregnant women was determined by a multiplex PCR-based method. The most frequent types were Ia (33.0%), II (25.8%) and V (21.8%). Other types found were Ib (8.9%), III (8.9%) and IV (1.6%). While type Ia was prevalent during the whole period (2002-2018), fluctuations in distribution of other types, specially V, were observed over time. Capsular type III, traditionally associated with severe neonatal infections, was poorly detected. Distribution of maternal GBS capsular types in the metropolitan area of Rio de Janeiro, with prevalence of Ia and II, is quite different from other parts of the world. The knowledge about GBS capsular type distribution is essential to predict the theoretical impact of developing capsule-based vaccines in the local population.
DOI: 10.6084/m9.figshare.21835170
title: Direct healthcare cost of hospital admissions for chronic non-communicable diseases sensitive to primary care in the elderly

description: Abstract Aging has imposed changes in the epidemiological profile and an increase in the prevalence of chronic non-communicable diseases (CNCDs). The aim was to estimate the direct cost related to hospital admissions of elderly people affected by CNCDs (hypertension, heart failure and diabetes mellitus) sensitive to primary care, in a medium-sized hospital, in the period 2015-2019. Secondly, we investigated whether clinical and demographic factors explain the costs and length of stay. The medical records of 165 elderly people were analyzed. We found a predominance of women with a mean age of 76.9 years. The most frequent cause of hospitalization was heart failure (62%), and the average length of stay was 9.5 days, and 16% of hospitalizations corresponded to rehospitalizations. Of these, 81% were caused by complications from the previous hospitalization. The estimated total cost was R$ 3 million. Male patients had a longer hospital stay compared to female patients. Hypertension and the total number of procedures were significant predictors of cost and length of stay. We found that in 5 years, the costs of hospital admissions for conditions sensitive to primary care in the elderly are considerable, indicating the relevance of investments in primary care.
DOI: 10.6084/m9.figshare.21835170.v1
title: Direct healthcare cost of hospital admissions for chronic non-communicable diseases sensitive to primary care in the elderly

description: Abstract Aging has imposed changes in the epidemiological profile and an increase in the prevalence of chronic non-communicable diseases (CNCDs). The aim was to estimate the direct cost related to hospital admissions of elderly people affected by CNCDs (hypertension, heart failure and diabetes mellitus) sensitive to primary care, in a medium-sized hospital, in the period 2015-2019. Secondly, we investigated whether clinical and demographic factors explain the costs and length of stay. The medical records of 165 elderly people were analyzed. We found a predominance of women with a mean age of 76.9 years. The most frequent cause of hospitalization was heart failure (62%), and the average length of stay was 9.5 days, and 16% of hospitalizations corresponded to rehospitalizations. Of these, 81% were caused by complications from the previous hospitalization. The estimated total cost was R$ 3 million. Male patients had a longer hospital stay compared to female patients. Hypertension and the total number of procedures were significant predictors of cost and length of stay. We found that in 5 years, the costs of hospital admissions for conditions sensitive to primary care in the elderly are considerable, indicating the relevance of investments in primary care.
DOI: 10.6084/m9.figshare.21835171
title: Fear and Human Trafficking

description: Abstract In this article I analyse the connections between fear and policies directed towards fighting human trafficking, considering the multi-sited ethnographic work carried since 2004, up to 2015 in Spain and up to the present moment in Brazil. In both countries the fieldwork involved observation in diverse places, situations and meetings and the interlocution with sex workers, migrants working in different labour sectors, sex industry entrepreneurs and agents connected with diverse governmentality domains. I analyse how people who should be protected by theses regimes feel fear of their effects because they provoke situations perceived as violence and consider how fear is a central emotion mobilized element in the dissemination of the anti-trafficking regimes. Finally, I show how the objects that incite fear have changed along the years, exploring the relations between these alterations and the political fields that these regimes integrate.
DOI: 10.6084/m9.figshare.21835171.v1
title: Fear and Human Trafficking

description: Abstract In this article I analyse the connections between fear and policies directed towards fighting human trafficking, considering the multi-sited ethnographic work carried since 2004, up to 2015 in Spain and up to the present moment in Brazil. In both countries the fieldwork involved observation in diverse places, situations and meetings and the interlocution with sex workers, migrants working in different labour sectors, sex industry entrepreneurs and agents connected with diverse governmentality domains. I analyse how people who should be protected by theses regimes feel fear of their effects because they provoke situations perceived as violence and consider how fear is a central emotion mobilized element in the dissemination of the anti-trafficking regimes. Finally, I show how the objects that incite fear have changed along the years, exploring the relations between these alterations and the political fields that these regimes integrate.
DOI: 10.6084/m9.figshare.9870866
title: Archival documents produced by scientific work: an analysis of laboratory notebooks from the Instituto Oswaldo Cruz

description: Resumo Analisa o caderno de laboratório, espécie documental produzida a partir dos registros da atividade científica, e seus diferentes tipos, bem como seu uso e seus formatos na pesquisa biomédica. A reflexão se apoia na pesquisa em andamento sobre os documentos dos laboratórios do Instituto Oswaldo Cruz e na relação destes com os conceitos, métodos, técnicas e práticas da arquivologia. A metodologia compreendeu, além de pesquisa bibliográfica, a aplicação de questionário, entrevistas e diagnóstico dos arquivos, nos quais se buscou identificar a gênese documental, as espécies/tipologias presentes e as práticas de manutenção e uso dos registros provenientes de 15 laboratórios. Discute ainda o caderno aberto de laboratório, formato disseminado no âmbito do debate contemporâneo da ciência aberta.
DOI: 10.6084/m9.figshare.9870866.v1
title: Archival documents produced by scientific work: an analysis of laboratory notebooks from the Instituto Oswaldo Cruz

description: Resumo Analisa o caderno de laboratório, espécie documental produzida a partir dos registros da atividade científica, e seus diferentes tipos, bem como seu uso e seus formatos na pesquisa biomédica. A reflexão se apoia na pesquisa em andamento sobre os documentos dos laboratórios do Instituto Oswaldo Cruz e na relação destes com os conceitos, métodos, técnicas e práticas da arquivologia. A metodologia compreendeu, além de pesquisa bibliográfica, a aplicação de questionário, entrevistas e diagnóstico dos arquivos, nos quais se buscou identificar a gênese documental, as espécies/tipologias presentes e as práticas de manutenção e uso dos registros provenientes de 15 laboratórios. Discute ainda o caderno aberto de laboratório, formato disseminado no âmbito do debate contemporâneo da ciência aberta.
DOI: 10.6084/m9.figshare.21835173.v1
title: Bimetallic Au-Pd/α-MoO3 Catalyst with High Oxygen Vacancies for Selective Oxidation of Cinnamyl Alcohol

description: Supported Au-Pd nanoparticles (NPs) have been extensively studied in alcohol oxidation reactions. However, few studies use reducible metal oxides as support, which can activate oxygen molecules and boost the selectivity of the reaction. In this work, Au-Pd NPs were supported on α-MoO3 and evaluated in the selective oxidation of cinnamyl alcohol without solvent. The Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and X-ray photoemission spectroscopy (XPS) analyses showed that the catalyst is richer in oxygen vacancies than the support, being probably responsible for the stability of the NPs (average size 4.62 ± 0.15 nm) and the high conversion and selectivity for the oxidation of cinnamyl alcohol. Furthermore, experiments have shown that the Au:Pd molar ratio influences the catalytic performance and can be optimized by controlling temperature, pressure, and reaction time. The catalyst proved to be active and selective for cinnamaldehyde in short reaction times. It showed satisfactory performance at 30 min and its best activity at 1 h with 94% conversion and 87% selectivity, without loss of activity and selectivity after four runs under the same reaction conditions.
DOI: 10.6084/m9.figshare.21835173
title: Bimetallic Au-Pd/α-MoO3 Catalyst with High Oxygen Vacancies for Selective Oxidation of Cinnamyl Alcohol

description: Supported Au-Pd nanoparticles (NPs) have been extensively studied in alcohol oxidation reactions. However, few studies use reducible metal oxides as support, which can activate oxygen molecules and boost the selectivity of the reaction. In this work, Au-Pd NPs were supported on α-MoO3 and evaluated in the selective oxidation of cinnamyl alcohol without solvent. The Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and X-ray photoemission spectroscopy (XPS) analyses showed that the catalyst is richer in oxygen vacancies than the support, being probably responsible for the stability of the NPs (average size 4.62 ± 0.15 nm) and the high conversion and selectivity for the oxidation of cinnamyl alcohol. Furthermore, experiments have shown that the Au:Pd molar ratio influences the catalytic performance and can be optimized by controlling temperature, pressure, and reaction time. The catalyst proved to be active and selective for cinnamaldehyde in short reaction times. It showed satisfactory performance at 30 min and its best activity at 1 h with 94% conversion and 87% selectivity, without loss of activity and selectivity after four runs under the same reaction conditions.
DOI: 10.6084/m9.figshare.21835176
title: Self-rated health and factors related to the work of basic education’s teachers in Brazil

description: Abstract The scope of this article is to analyze the association between teachers’ self-rated health and the conditions in which they work in Basic Education schools in Brazil. It involved a cross-sectional study, carried out between 2015 and 2016, representative of Basic Education teachers in the country, the outcome variable of which was self-rated health (SRH). The explanatory variables were the work-related characteristics. To assess the factors associated with SRH, the Proportional Odds Logistic Regression Model was used. The prevalence of poor SRH was 27%. The probability of poor SRH was significantly higher for the group that reported episodes of verbal violence (OR=1.26; 95%CI 1.09-1.44), work pressure (OR=1.18; 95%CI 1, 04-1.33), and a commute to school of more than 50 minutes (OR=1.19; 95%CI 1.03-1.38). The probability of poor SRH was significantly better for those who reported having enough time to complete their tasks (OR=0.77; 95%CI 0.64-0.92), social support (OR=0.79; 95%CI 0.69-0.89) and satisfaction with their workload (OR=0.79; 95%CI 0.69-0.91). Actions on the school environment and organization and improvements in the transport of teachers to work are desirable.
DOI: 10.6084/m9.figshare.21835176.v1
title: Self-rated health and factors related to the work of basic education’s teachers in Brazil

description: Abstract The scope of this article is to analyze the association between teachers’ self-rated health and the conditions in which they work in Basic Education schools in Brazil. It involved a cross-sectional study, carried out between 2015 and 2016, representative of Basic Education teachers in the country, the outcome variable of which was self-rated health (SRH). The explanatory variables were the work-related characteristics. To assess the factors associated with SRH, the Proportional Odds Logistic Regression Model was used. The prevalence of poor SRH was 27%. The probability of poor SRH was significantly higher for the group that reported episodes of verbal violence (OR=1.26; 95%CI 1.09-1.44), work pressure (OR=1.18; 95%CI 1, 04-1.33), and a commute to school of more than 50 minutes (OR=1.19; 95%CI 1.03-1.38). The probability of poor SRH was significantly better for those who reported having enough time to complete their tasks (OR=0.77; 95%CI 0.64-0.92), social support (OR=0.79; 95%CI 0.69-0.89) and satisfaction with their workload (OR=0.79; 95%CI 0.69-0.91). Actions on the school environment and organization and improvements in the transport of teachers to work are desirable.
DOI: 10.6084/m9.figshare.21835179
title: In vitro sperm characteristics and in vivo fertility of sex-sorted and conventional semen in suckled Nelore cows at a traditional schedule for timed-AI with estrus detection

description: ABSTRACT The aim of this study was to assess in vitro sperm characteristics and pregnancies/AI (P/AI) of conventional and sex-sorted semen at timed-AI of suckled, multiparous Nelore cows. All cows (n=348) were submitted to a traditional estradiol/progesterone(P4)-based protocol. At 48h after P4-device removal, the estrous behavior was recorded, and AI was performed with conventional or sex-sorted semen from two bulls. The following sperm assessments were performed: CASA, Hyposmotic Test, sperm morphometry and chromatin structure by TB staining. P/AI were reduced (P&lt;0.001) for sex-sorted compared to conventional semen in cows expressing estrus (27vs47%) or not (11vs.37%). Membrane integrity (Bull1: 30.3±9.6 vs. 52.3±12.4%, P=0.01; Bull2: 24.5±3.0 vs. 48.7±1.6%, P=0.006) and sperm concentration (Bull1: 23.2±0.6 vs. 43.0±0.8x10⁶sperm/mL, P&lt;0.001; Bull2: 25.1±2.8 vs. 42.1±0.7x10⁶sperm/mL; P&lt;0.001) were reduced in sex-sorted compared to conventional semen, for both bulls. Total and progressive motility were reduced in sex-sorted semen for Bull1 (TM: 49.7±15.9 vs. 94.9±1.9%, P=0.007; PM: 16.7±3.4 vs. 44.1±13.2%, P=0.009) and no differences were detected for Bull2 (TM: 45.0±17.5 vs. 68.2±19.1%, P=0.098; PM: 12.8±4.7 vs. 30.0±13.0%, P=0.065). Sperm ellipticity from sex-sorted was lower than conventional semen for Bull2 (0.306±0.01 vs. 0.342±0.02, P=0.02) and no difference was detected for Bull1 (0.332±0.01 vs. 0.330±0.01, P=0.55). Reduced in vivo fertility was observed for sex-sorted semen, regardless of estrous behavior. In vitro sperm quality of sex-sorted semen was compromised for both bulls, but differently affected for each sire.
DOI: 10.6084/m9.figshare.21835179.v1
title: In vitro sperm characteristics and in vivo fertility of sex-sorted and conventional semen in suckled Nelore cows at a traditional schedule for timed-AI with estrus detection

description: ABSTRACT The aim of this study was to assess in vitro sperm characteristics and pregnancies/AI (P/AI) of conventional and sex-sorted semen at timed-AI of suckled, multiparous Nelore cows. All cows (n=348) were submitted to a traditional estradiol/progesterone(P4)-based protocol. At 48h after P4-device removal, the estrous behavior was recorded, and AI was performed with conventional or sex-sorted semen from two bulls. The following sperm assessments were performed: CASA, Hyposmotic Test, sperm morphometry and chromatin structure by TB staining. P/AI were reduced (P&lt;0.001) for sex-sorted compared to conventional semen in cows expressing estrus (27vs47%) or not (11vs.37%). Membrane integrity (Bull1: 30.3±9.6 vs. 52.3±12.4%, P=0.01; Bull2: 24.5±3.0 vs. 48.7±1.6%, P=0.006) and sperm concentration (Bull1: 23.2±0.6 vs. 43.0±0.8x10⁶sperm/mL, P&lt;0.001; Bull2: 25.1±2.8 vs. 42.1±0.7x10⁶sperm/mL; P&lt;0.001) were reduced in sex-sorted compared to conventional semen, for both bulls. Total and progressive motility were reduced in sex-sorted semen for Bull1 (TM: 49.7±15.9 vs. 94.9±1.9%, P=0.007; PM: 16.7±3.4 vs. 44.1±13.2%, P=0.009) and no differences were detected for Bull2 (TM: 45.0±17.5 vs. 68.2±19.1%, P=0.098; PM: 12.8±4.7 vs. 30.0±13.0%, P=0.065). Sperm ellipticity from sex-sorted was lower than conventional semen for Bull2 (0.306±0.01 vs. 0.342±0.02, P=0.02) and no difference was detected for Bull1 (0.332±0.01 vs. 0.330±0.01, P=0.55). Reduced in vivo fertility was observed for sex-sorted semen, regardless of estrous behavior. In vitro sperm quality of sex-sorted semen was compromised for both bulls, but differently affected for each sire.
DOI: 10.6084/m9.figshare.21835182
title: Associated factors and treatment options for sleep bruxism in children: an umbrella review

description: Abstract Data on clinical management options for sleep bruxism in the primary dentition are inconclusive. This umbrella review aimed to synthesize the available evidence from systematic reviews (SRs) on the associated factors and treatment approaches for clinical management of sleep bruxism in children. A search was conducted in the MEDLINE/PubMed, Web of Science, Embase, and OpenGrey databases up to March 2022. SRs published on sleep bruxism in children containing data on associated factors or treatment outcomes were included. The AMSTAR-2 tool was used to assess the methodological quality of SRs. The search identified 444 articles, of which six were included. Sleep conditions, respiratory changes, personality traits, and psychosocial factors were the associated factors commonly identified. Treatments included psychological and pharmacological therapies, occlusal devices, physical therapy, and surgical therapy. All SRs included presented a high risk of bias. Overlapping of the included studies was considered very high. The best evidence available to date for the management of sleep bruxism in children is based on associated factors, with sleep duration and conditions, respiratory changes, as well as personality traits and psychosocial factors being the most important factors commonly reported by studies. However, there is currently insufficient evidence to make recommendations for specific treatment options.
DOI: 10.6084/m9.figshare.21835182.v1
title: Associated factors and treatment options for sleep bruxism in children: an umbrella review

description: Abstract Data on clinical management options for sleep bruxism in the primary dentition are inconclusive. This umbrella review aimed to synthesize the available evidence from systematic reviews (SRs) on the associated factors and treatment approaches for clinical management of sleep bruxism in children. A search was conducted in the MEDLINE/PubMed, Web of Science, Embase, and OpenGrey databases up to March 2022. SRs published on sleep bruxism in children containing data on associated factors or treatment outcomes were included. The AMSTAR-2 tool was used to assess the methodological quality of SRs. The search identified 444 articles, of which six were included. Sleep conditions, respiratory changes, personality traits, and psychosocial factors were the associated factors commonly identified. Treatments included psychological and pharmacological therapies, occlusal devices, physical therapy, and surgical therapy. All SRs included presented a high risk of bias. Overlapping of the included studies was considered very high. The best evidence available to date for the management of sleep bruxism in children is based on associated factors, with sleep duration and conditions, respiratory changes, as well as personality traits and psychosocial factors being the most important factors commonly reported by studies. However, there is currently insufficient evidence to make recommendations for specific treatment options.
DOI: 10.6084/m9.figshare.21835180
title: Glyceryl behenate-based solid lipid nanoparticles as a carrier of haloperidol for nose to brain delivery: formulation development, in-vitro, and in-vivo evaluation

description: Abstract This study was aimed to develop the haloperidol (HPL) loaded solid lipid nanoparticles (SLNs) for brain targeting through the intranasal route. SLNs were fabricated by the emulsification diffusion technique using glyceryl behenate as lipid and tween 80 as a surfactant. SLNs were evaluated for particle size, zeta potential, structure, entrapment efficiency, solid state characterization by differential scanning calorimetry (DSC), and in-vitro release. In-vivo biological evaluation was performed on albino Wistar rats for the determination of pharmacokinetic as well as brain targeting parameters. Particle size, PDI, zeta potential, and entrapment efficiency of optimized formulation (HPL-SLNs 6) were found to be 103±09 nm, 0.190±0.029, -23.5±1.07 mV, and 79.46±1.97% respectively. In-vitro drug release studies exhibited that 87.21± 3.63% of the entrapped drug was released from the SLNs within 24 h. DSC curves confirmed that during entrapment in SLNs, the drug was solubilized in the lipid matrix and converted into the amorphous form. Enhanced HPL targeting to the brain was observed from HPL-SLNs as compared to HPL-Sol when administered intranasally. The value of AUC 0-∞ in the brain for HPL-SLNs i.n. was found to be nearly 2.7 times higher than that of HPL-Sol i.v., whereas 3.66 times superior to HPL-Sol administered i.n. Stability studies revealed that the formulation remains unchanged when stored at 4±2 °C (refrigerator) and 25±2 °C /60 ±5% RH up to six months. Finally, it could be concluded that SLN is a suitable carrier for HPL with enhanced brain targeting through i.n administration, as compared to the HPL-Sol, administered i.n. and i.v.