cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.15005850
title: Dataset related to article "Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer"

description: This record contains raw data related to article "Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer"

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. PDAC is characterized by a complex tumor microenvironment (TME), that plays a pivotal role in disease progression and resistance to therapy. Investigating the spatial distribution and interaction of TME cells with the tumor is the basis for understanding the mechanisms underlying disease progression and represents a current challenge in PDAC research. Imaging mass cytometry (IMC) is the major multiplex imaging technology for the spatial analysis of tumor heterogeneity. However, there is a dearth of reports of multiplexed IMC panels for different preclinical mouse models, including pancreatic cancer. We addressed this gap by utilizing two preclinical models of PDAC: the genetically engineered, bearing KRAS–TP53 mutations in pancreatic cells, and the orthotopic, and developed a 28–marker panel for single–cell IMC analysis to assess the abundance, distribution and phenotypes of cells involved in PDAC progression and their reciprocal functional interactions. Herein, we provide an unprecedented definition of the distribution of TME cells in PDAC and compare the diversity between transplanted and genetic disease models. The results obtained represent an important and customizable tool for unraveling the complexities of PDAC and deciphering the mechanisms behind therapy resistance.
DOI: 10.5281/zenodo.15005851
title: Dataset related to article "Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer"

description: This record contains raw data related to article "Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer"

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. PDAC is characterized by a complex tumor microenvironment (TME), that plays a pivotal role in disease progression and resistance to therapy. Investigating the spatial distribution and interaction of TME cells with the tumor is the basis for understanding the mechanisms underlying disease progression and represents a current challenge in PDAC research. Imaging mass cytometry (IMC) is the major multiplex imaging technology for the spatial analysis of tumor heterogeneity. However, there is a dearth of reports of multiplexed IMC panels for different preclinical mouse models, including pancreatic cancer. We addressed this gap by utilizing two preclinical models of PDAC: the genetically engineered, bearing KRAS–TP53 mutations in pancreatic cells, and the orthotopic, and developed a 28–marker panel for single–cell IMC analysis to assess the abundance, distribution and phenotypes of cells involved in PDAC progression and their reciprocal functional interactions. Herein, we provide an unprecedented definition of the distribution of TME cells in PDAC and compare the diversity between transplanted and genetic disease models. The results obtained represent an important and customizable tool for unraveling the complexities of PDAC and deciphering the mechanisms behind therapy resistance.
DOI: 10.15468/dl.nrpqxc
title: Occurrence Download

description: A dataset containing 493 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry MULTIPOLYGON(((-104.05245 41.39323,-104.05321 41.00164,-102.05176 41.00233,-102.05171 40.00317,-95.30809 39.99995,-95.41589 40.04143,-95.39319 40.11833,-95.4797 40.18649,-95.47738 40.24258,-95.55096 40.26071,-95.56349 40.29781,-95.65572 40.30998,-95.62317 40.34447,-95.70043 40.50521,-95.66175 40.51739,-95.65581 40.54662,-95.67852 40.56259,-95.70869 40.5214,-95.76553 40.52996,-95.77421 40.57478,-95.7499 40.60685,-95.8859 40.72284,-95.83466 40.78099,-95.84842 40.86318,-95.80935 40.89164,-95.88248 41.05944,-95.86243 41.09037,-95.8829 41.15477,-95.84133 41.17592,-95.92792 41.19798,-95.91076 41.23268,-95.92775 41.29868,-95.90622 41.30129,-95.9037 41.27423,-95.87205 41.30253,-95.95578 41.34269,-95.92918 41.368,-95.92056 41.45182,-96.01263 41.47714,-96.00047 41.54001,-96.04822 41.51609,-96.09407 41.53852,-96.0813 41.57658,-96.11813 41.61547,-96.09484 41.65309,-96.12227 41.68462,-96.07286 41.70494,-96.10644 41.73894,-96.06449 41.79504,-96.16219 41.90263,-96.13011 41.97145,-96.1889 41.97822,-96.19438 42.00942,-96.24166 41.99913,-96.22222 42.02977,-96.27421 42.04773,-96.27112 42.11659,-96.34927 42.17011,-96.35986 42.21081,-96.32363 42.23001,-96.32917 42.25477,-96.41747 42.35218,-96.38579 42.47528,-96.50037 42.48249,-96.54862 42.51986,-96.61255 42.50555,-96.70867 42.60204,-96.70027 42.65465,-96.79382 42.66645,-96.80726 42.70233,-96.8979 42.73263,-96.95522 42.71814,-96.97533 42.75749,-97.13216 42.77229,-97.2117 42.81054,-97.21975 42.84633,-97.31693 42.86885,-97.44928 42.84571,-97.49371 42.86814,-97.59111 42.84262,-97.61624 42.86606,-97.67471 42.83121,-97.71618 42.86155,-97.77746 42.83668,-97.84329 42.86805,-97.87613 42.85738,-97.92051 42.78913,-98.01567 42.76224,-98.14674 42.83954,-98.44416 42.92873,-98.49857 42.99867,-104.05308 43.00056,-104.05245 41.39323)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Penstemon Schmidel",
 "Year 2000-2025"
 ]
}

 The dataset includes 493 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003049-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mc787y
title: Occurrence Download

description: A dataset containing 42274 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rosa canina var. canina)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Geometry POLYGON((-180 -90,180 -90,180 90,-180 90,-180 -90))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1945"
 ]
}

 The dataset includes 42274 records from 72 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003048-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hf6abb
title: Occurrence Download

description: A dataset listing the 2812 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Canadian Museum of Nature Crustacea Collection"
 ]
}

 The dataset's 2812 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003041-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fdru6z
title: Occurrence Download

description: A dataset containing 2047 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Canada",
 "GadmGid is CAN.1_1",
 "TaxonKey is Cistothorus stellaris (J.F.Naumann, 1823)"
 ]
}

 The dataset includes 2047 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003050-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yehq29
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Pteris incompleta Cav.)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 26 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003051-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2xt2fx
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-1.9 53.6,-1.8 53.6,-1.8 53.7,-1.9 53.7,-1.9 53.6))",
 "HasCoordinate is true",
 "TaxonKey is Pipistrellus pipistrellus (Schreber, 1774)",
 "Year 2013-2015"
 ]
}

 The dataset's 1 records were derived from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003040-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15005984
title: Dataset related to article "Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts"

description: This record contains raw data related to article "Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts"

Abstract

Introduction: Pancreatic ductal adenocarcinoma (PDAC) represents the complexity of interaction between cancer and cells of the tumor microenvironment (TME). Immune cells affect tumor cell behavior, thus driving cancer progression. Cancer-associated fibroblasts (CAFs) are responsible of the desmoplastic and fibrotic reaction by regulating deposition and remodeling of extracellular matrix (ECM). As tumor-promoting cells abundant in PDAC ECM, CAFs represent promising targets for novel anticancer interventions. However, relevant clinical trials are hampered by the lack of specific markers and elusive differences among CAF subtypes. Indeed, while single-cell transcriptomic analyses have provided important information on the cellular constituents of PDACs and related molecular pathways, studies based on the identification of protein markers in tissues aimed at identifying CAF subtypes and new molecular targets result incomplete.Methods: Herein, we applied multiplexed Imaging Mass Cytometry (IMC) at single-cell resolution on 8 human PDAC tissues to depict the PDAC composing cells, and profiling immune cells, endothelial cells (ECs), as well as endocrine cells and tumor cells.Results: We focused on CAFs by characterizing up to 19 clusters distinguished by phenotype, spatiality, and interaction with immune and tumor cells. We report evidence that specific subtypes of CAFs (CAFs 10 and 11) predominantly are enriched at the tumor-stroma interface and closely associated with tumor cells. CAFs expressing different combinations of FAP, podoplanin and cadherin-11, were associated with a higher level of CA19-9. Moreover, we identified specific subsets of FAP+ and podoplanin+/cadherin-11+ CAFs enriched in patients with negative prognosis.Discussion: The present study provides new general insights into the complexity of the PDAC microenvironment by defining phenotypic heterogeneities and spatial distributions of CAFs, thus suggesting different functions of their subtypes in the PDAC microenvironment.
DOI: 10.5281/zenodo.15005985
title: Dataset related to article "Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts"

description: This record contains raw data related to article "Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts"

Abstract

Introduction: Pancreatic ductal adenocarcinoma (PDAC) represents the complexity of interaction between cancer and cells of the tumor microenvironment (TME). Immune cells affect tumor cell behavior, thus driving cancer progression. Cancer-associated fibroblasts (CAFs) are responsible of the desmoplastic and fibrotic reaction by regulating deposition and remodeling of extracellular matrix (ECM). As tumor-promoting cells abundant in PDAC ECM, CAFs represent promising targets for novel anticancer interventions. However, relevant clinical trials are hampered by the lack of specific markers and elusive differences among CAF subtypes. Indeed, while single-cell transcriptomic analyses have provided important information on the cellular constituents of PDACs and related molecular pathways, studies based on the identification of protein markers in tissues aimed at identifying CAF subtypes and new molecular targets result incomplete.Methods: Herein, we applied multiplexed Imaging Mass Cytometry (IMC) at single-cell resolution on 8 human PDAC tissues to depict the PDAC composing cells, and profiling immune cells, endothelial cells (ECs), as well as endocrine cells and tumor cells.Results: We focused on CAFs by characterizing up to 19 clusters distinguished by phenotype, spatiality, and interaction with immune and tumor cells. We report evidence that specific subtypes of CAFs (CAFs 10 and 11) predominantly are enriched at the tumor-stroma interface and closely associated with tumor cells. CAFs expressing different combinations of FAP, podoplanin and cadherin-11, were associated with a higher level of CA19-9. Moreover, we identified specific subsets of FAP+ and podoplanin+/cadherin-11+ CAFs enriched in patients with negative prognosis.Discussion: The present study provides new general insights into the complexity of the PDAC microenvironment by defining phenotypic heterogeneities and spatial distributions of CAFs, thus suggesting different functions of their subtypes in the PDAC microenvironment.
DOI: 10.15468/dl.ebxxas
title: Occurrence Download

description: A dataset containing 311 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dioscorea filiformis Blume"
 ]
}

 The dataset includes 311 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003052-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n4ux77
title: Occurrence Download

description: A dataset containing 193 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rosa ×damascena Mill.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Geometry POLYGON((-180 -90,180 -90,180 90,-180 90,-180 -90))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1945"
 ]
}

 The dataset includes 193 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003055-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ss2kq4
title: Occurrence Download

description: A dataset containing 83 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ranunculus parnassiifolius L.)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 83 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003054-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6n2gjj
title: Occurrence Download

description: A dataset containing 52754 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetName is Hudson Bay Lowlands Project",
 "InstitutionKey is c146edb6-3a82-473c-b337-4acaa92f9513"
 ]
}

 The dataset includes 52754 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003036-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25810/rxtv-eb29.83
title: German Newspaper Coverage of Climate Change or Global Warming, 2004-2025 - February 2025

description: The Media and Climate Change Observatory Data monitors 126 sources (across newspapers, radio and TV) in 58 countries in seven different regions around the world. Data is assembled by accessing archives through the Lexis Nexis, Proquest and Factiva databases via the University of Colorado libraries. More information may be found at: http://mecco.colorado.edu.
DOI: 10.15468/dl.r7fg9b
title: Occurrence Download

description: A dataset containing 208229 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Bombus terrestris (Linnaeus, 1758), Andrena haemorrhoa (Fabricius, 1781), Xylocopa appendiculata Smith, 1852, Trigona carbonaria Smith, 1854, Melipona beecheii Bennett, 1831, Apis andreniformis Smith, 1857, Apis florea Fabricius, 1787, Apis laboriosa Smith, 1871, Apis dorsata Fabricius, 1793, Apis cerana Fabricius, 1793, Apis mellifera Linnaeus, 1758)",
 "Year is 2024"
 ]
}

 The dataset includes 208229 records from 63 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003044-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hbtzrs
title: Occurrence Download

description: A dataset containing 15496 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-120 -60,-25.003 -60,-25.003 30,-120 30,-120 -60))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "PublishingOrg is b3bf3a83-1f68-4541-a03f-330d30d567f5",
 "TaxonKey is Aves"
 ]
}

 The dataset includes 15496 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003056-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6s9vq7
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ranunculus weyleri Marès)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 12 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003059-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tkqu2j
title: Occurrence Download

description: A dataset containing 7617 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rosa gallica L.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Geometry POLYGON((-180 -90,180 -90,180 90,-180 90,-180 -90))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1945"
 ]
}

 The dataset includes 7617 records from 255 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003061-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.db9g2h
title: Occurrence Download

description: A dataset containing 596 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Bothrops atrox (Linnaeus, 1758), Nymphargus puyoensis (Flores & McDiarmid, 1989))"
 ]
}

 The dataset includes 596 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003062-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4tkzt5
title: Occurrence Download

description: A dataset containing 536 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ruscus aculeatus L.)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 536 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003064-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q5xhn8
title: Occurrence Download

description: A dataset containing 6652 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Bombus terrestris (Linnaeus, 1758), Andrena haemorrhoa (Fabricius, 1781), Xylocopa appendiculata Smith, 1852, Trigona carbonaria Smith, 1854, Melipona beecheii Bennett, 1831, Apis andreniformis Smith, 1857, Apis florea Fabricius, 1787, Apis laboriosa Smith, 1871, Apis dorsata Fabricius, 1793, Apis cerana Fabricius, 1793, Apis mellifera Linnaeus, 1758)",
 "Year is 2025"
 ]
}

 The dataset includes 6652 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003065-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.99fzby
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-0.7 51.4,-0.6 51.4,-0.6 51.5,-0.7 51.5,-0.7 51.4))",
 "HasCoordinate is true",
 "TaxonKey is Pipistrellus pipistrellus (Schreber, 1774)",
 "Year 2013-2015"
 ]
}

 The dataset's 1 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003053-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2qc9ba
title: Occurrence Download

description: A dataset containing 664 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Rosa glabrifolia C.A.Mey. ex Rupr.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Geometry POLYGON((-180 -90,180 -90,180 90,-180 90,-180 -90))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1945"
 ]
}

 The dataset includes 664 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003066-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.55s7tz
title: Occurrence Download

description: A dataset containing 288 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Salix salviifolia Brot.)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 288 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003067-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.