cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7678103.v1
title: An electronic warning system helps reduce the time to diagnosis of sepsis

description: ABSTRACT Objective: To describe the improvements of an early warning system for the identification of septic patients on the time to diagnosis, antibiotic delivery, and mortality. Methods: This was an observational cohort study that describes the successive improvements made over a period of 10 years using an early warning system to detect sepsis, including systematic active manual surveillance, electronic alerts via a telephonist, and alerts sent directly to the mobile devices of nurses. For all periods, after an alert was triggered, early treatment was instituted according to the institutional sepsis guidelines. Results: In total, 637 patients with sepsis were detected over the study period. The median triage-to-diagnosis time was reduced from 19:20 (9:10 - 38:15) hours to 12:40 (2:50 - 23:45) hours when the manual surveillance method was used (p = 0.14), to 2:10 (1:25 - 2:20) hours when the alert was sent automatically to the hospital telephone service (p = 0.014), and to 1:00 (0:30 - 1:10) hour when the alert was sent directly to the nurse's mobile phone (p = 0.016). The diagnosis-to-antibiotic time was reduced to 1:00 (0:55 - 1:30) hours when the alert was sent to the telephonist and to 0:45 (0:30 - 1:00) minutes when the alert was sent directly to the nurse's mobile phone (p = 0.02), with the maintenance of similar values over the following years. There was no difference in the time of treatment between survivors and non-survivors. Conclusion: Electronic systems help reduce the triage-to-diagnosis time and diagnosis-to-antibiotic time in patients with sepsis.
DOI: 10.6084/m9.figshare.7678091
title: Control of early blight and bacterial spot in tomato by Rosmarinus officinalis extract

description: ABSTRACT Aiming to develop new measures of plant protection against diseases, the objective of this study was to verify the control of early blight (Alternaria solani) and bacterial spot (Xanthomonas vesicatoria) in tomato plants, as well as the antimicrobial activity against their causal agents, using soluble powder of rosemary (Rosmarinus officinalis). For the stability test, the soluble powder was kept at 40 oC during 0, 60, 120 and 180 days and assayed at five concentrations (0, 50, 100, 150 and 200 mg L-1). When the shelf life and the best concentration were defined, the application intervals of seven, 14 and 21 days were evaluated. As control treatments, the following fungicides were used: Azoxystrobin (200 mg active ingredient – a.i mL-1) for early blight and Copper Oxychloride (400 mg a.i. mL-1) for bacterial spot. There was no in vitro antimicrobial activity of the extract against A. solani and X. vesicatoria. The calculated concentration of rosemary extract that resulted in the least severity of diseases was 130 mg L-1, with 24 months of shelf life of the soluble powder. The extract provided the same control level for early blight and bacterial spot as that of the used fungicides, showing efficiency of up to 75% at a seven-day application interval. These results show the efficiency of rosemary soluble powder in controlling early blight and bacterial spot in tomato plants.
DOI: 10.6084/m9.figshare.7678097.v1
title: Mannheimia haemolytica pleuropneumonia in goats associated with shipping stress

description: ABSTRACT: This study described the epidemiological, clinical, pathological and bacteriological aspects of Mannheimia haemolytica pleuropneumonia in goats associated with shipping stress. Forty goats transported from the Northeast to the Southern region of Brazil died during shipment, or 2-3 days after unloading. Clinical signs included dyspnea, mucopurulent nasal discharge, and coughing. All goats were necropsied, and multiple tissues were collected for histopathological analysis and involved agent identifications. All lungs showed pulmonary consolidation, predominantly affecting the cranioventral lobes, in addition to the marked fibrinous pleuritis, pleural thickening, and pleural adhesions, that affected 90% of the goats. Histologically, there was fibrino-suppurative pleuropneumonia characterized by a diffuse neutrophilic infiltrate admixed with fibrin. Non-hemolytic [85% (34/40)] and hemolytic [15% (6/40)] species were obtained in bacteriological culture. Fir Mannheimia spp. was reported in 26 isolates and subsequently confirmed as M. haemolytica (99% identity), after amplification and partial sequencing of the 16S rDNA gene. Stress may trigger the development of bacterial pleuropneumonia in goats, and non-hemolytic strains of M. haemolytica may cause this condition in goats with severe immunosuppression.
DOI: 10.6084/m9.figshare.7678100.v1
title: Fast Determination of Iodine Number of Biodiesel Using Capillary Zone Electrophoresis with Multi- and Single-Point Calibration

description: A new and fast method was developed to determine the iodine number of biodiesel samples by capillary zone electrophoresis (CZE). In this procedure, the biodiesel sample reacts with Wijs solution in the presence of a catalyst and all the remaining iodine monochloride is converted to the iodide ion, which is quantified by CZE. Only small amounts of sample and reactant are required and µL level amounts of chloroform and Wijs solution. The reaction time was reduced to 3 min and the total analysis time is less than 15 min. The simplicity and speed of the method can be further enhanced by using single-point calibration. The limits of quantification (LOQ) and determination (LOD) values were better than 0.6 and 0.18 g per 100 g of biodiesel. Instrumental, intraday, and interday precisions were better than 1.13, 1.04 and 6.02% relative standard deviation (RSD). The accuracy was statistically verified by comparison with the standard method EN 14111.
DOI: 10.7284/106306
title: GNSS (Global Navigation Satellite System) data collected during research cruise BH11-21 using a Northstar 941X instrument system onboard the platform RV Blue Heron

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7678085
title: Clinical Course of Patients Undergoing Myocardial Revascularization Surgery in a Public Cardiology Referral Hospital in Pará, Brazil

description: Abstract Background: Myocardial revascularization surgery (MRS) is the most frequently performed cardiac surgery in Brazil. However, data on mortality rates among patients undergoing MRS in hospitals other than the main referral centers in the northern Brazil are scarce. Objective: To describe the clinical course of patients that submitted to MRS in the major public cardiology referral hospital in the Brazilian Amazon. Methods: Retrospective cohort analysis, by review of medical records of patients who had undergone MRS at Hospital das Clínicas Gaspar Vianna (FHCGV) from January 2013 to June 2014. Results: A total of 179 patients were evaluated. Mortality rate was 11.7% until 30 days after surgery. Waiting time for surgery ≥ 30 days (OR 2.59, 95%CI 1.02 - 6.56, p = 0.039), infection during hospitalization (OR 3.28, 95%CI 1.15 - 9.39, p = 0.021) and need for hemodialysis after surgery (OR 9.06 95%CI 2.07 - 39.54, p = 0.001) were predictors of mortality after CABG. Conclusion: A high mortality rate in the study population was found, higher than that reported in the literature and in other regions of Brazil.
DOI: 10.6084/m9.figshare.7678088
title: Potential of dioecious progenies of papaya plants for resistance to powdery mildew

description: ABSTRACT Landraces are important sources of genetic variability to be exploited by plant breeding programs. In Brazil, papaya is commercially grown mainly in the states of Espirito Santo and Bahia but, domestically, it is grown throughout the extensive Brazilian territory. However, exploration studies of genetic variability in local varieties of papaya are incipient in the country. The aim of this study was to evaluate the potential of 20 dioecious papaya genotypes for traits related to resistance to powdery mildew (Streptopodium caricae). Thus, this experiment was conducted in a greenhouse, in randomized block design, with four replicates and one plant per plot. The following were evaluated: incidence of leaves with powdery mildew symptoms and severity of powdery mildew in the fifth and seventh leaves. The obtained data were subjected to analysis of variance and mean comparison test via the least squares method. The variance components and the genetic value of progenies for incidence and severity of powdery mildew were also estimated via mixed models. There was a favorable situation for selection aimed at resistance to powdery mildew, with heritability ranging from 51.57 to 67.82 and selective accuracy above 70%. PMI1, PMI6, PMI8, PMI11, PMI12 and PMI15 stood out for presenting potential to reduce both the incidence and the severity of powdery mildew on foliage.
DOI: 10.6084/m9.figshare.7678091.v1
title: Control of early blight and bacterial spot in tomato by Rosmarinus officinalis extract

description: ABSTRACT Aiming to develop new measures of plant protection against diseases, the objective of this study was to verify the control of early blight (Alternaria solani) and bacterial spot (Xanthomonas vesicatoria) in tomato plants, as well as the antimicrobial activity against their causal agents, using soluble powder of rosemary (Rosmarinus officinalis). For the stability test, the soluble powder was kept at 40 oC during 0, 60, 120 and 180 days and assayed at five concentrations (0, 50, 100, 150 and 200 mg L-1). When the shelf life and the best concentration were defined, the application intervals of seven, 14 and 21 days were evaluated. As control treatments, the following fungicides were used: Azoxystrobin (200 mg active ingredient – a.i mL-1) for early blight and Copper Oxychloride (400 mg a.i. mL-1) for bacterial spot. There was no in vitro antimicrobial activity of the extract against A. solani and X. vesicatoria. The calculated concentration of rosemary extract that resulted in the least severity of diseases was 130 mg L-1, with 24 months of shelf life of the soluble powder. The extract provided the same control level for early blight and bacterial spot as that of the used fungicides, showing efficiency of up to 75% at a seven-day application interval. These results show the efficiency of rosemary soluble powder in controlling early blight and bacterial spot in tomato plants.
DOI: 10.6084/m9.figshare.7678085.v1
title: Clinical Course of Patients Undergoing Myocardial Revascularization Surgery in a Public Cardiology Referral Hospital in Pará, Brazil

description: Abstract Background: Myocardial revascularization surgery (MRS) is the most frequently performed cardiac surgery in Brazil. However, data on mortality rates among patients undergoing MRS in hospitals other than the main referral centers in the northern Brazil are scarce. Objective: To describe the clinical course of patients that submitted to MRS in the major public cardiology referral hospital in the Brazilian Amazon. Methods: Retrospective cohort analysis, by review of medical records of patients who had undergone MRS at Hospital das Clínicas Gaspar Vianna (FHCGV) from January 2013 to June 2014. Results: A total of 179 patients were evaluated. Mortality rate was 11.7% until 30 days after surgery. Waiting time for surgery ≥ 30 days (OR 2.59, 95%CI 1.02 - 6.56, p = 0.039), infection during hospitalization (OR 3.28, 95%CI 1.15 - 9.39, p = 0.021) and need for hemodialysis after surgery (OR 9.06 95%CI 2.07 - 39.54, p = 0.001) were predictors of mortality after CABG. Conclusion: A high mortality rate in the study population was found, higher than that reported in the literature and in other regions of Brazil.
DOI: 10.6084/m9.figshare.7678088.v1
title: Potential of dioecious progenies of papaya plants for resistance to powdery mildew

description: ABSTRACT Landraces are important sources of genetic variability to be exploited by plant breeding programs. In Brazil, papaya is commercially grown mainly in the states of Espirito Santo and Bahia but, domestically, it is grown throughout the extensive Brazilian territory. However, exploration studies of genetic variability in local varieties of papaya are incipient in the country. The aim of this study was to evaluate the potential of 20 dioecious papaya genotypes for traits related to resistance to powdery mildew (Streptopodium caricae). Thus, this experiment was conducted in a greenhouse, in randomized block design, with four replicates and one plant per plot. The following were evaluated: incidence of leaves with powdery mildew symptoms and severity of powdery mildew in the fifth and seventh leaves. The obtained data were subjected to analysis of variance and mean comparison test via the least squares method. The variance components and the genetic value of progenies for incidence and severity of powdery mildew were also estimated via mixed models. There was a favorable situation for selection aimed at resistance to powdery mildew, with heritability ranging from 51.57 to 67.82 and selective accuracy above 70%. PMI1, PMI6, PMI8, PMI11, PMI12 and PMI15 stood out for presenting potential to reduce both the incidence and the severity of powdery mildew on foliage.
DOI: 10.7284/106307
title: GNSS (Global Navigation Satellite System) data collected during research cruise BH11-22 using a Northstar 941X instrument system onboard the platform RV Blue Heron

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7678067
title: Digital elevation model quality on digital soil mapping prediction accuracy

description: ABSTRACT Digital elevation models (DEM) used in digital soil mapping (DSM) are commonly selected based on measures and indicators (quality criteria) that are thought to reflect how well a given DEM represents the terrain surface. The hypothesis is that the more accurate a DEM, the more accurate will be the DSM predictions. The objective of this study was to assess different criteria to identify the DEM that delivers the most accurate DSM predictions. A set of 10 criteria were used to evaluate the quality of nine DEMs constructed with different data sources, processing routines and three resolutions (5, 20, and 30 m). Multinomial logistic regression models were calibrated using 157 soil observations and terrain attributes derived from each DEM. Soil class predictions were validated using leave-one-out cross-validation. Results showed that, for each resolution, the quality criteria are useful to identify the DEM that more accurately represents the terrain surface. However, for all three resolutions, the most accurate DEM did not produce the most accurate DSM predictions. With the 20-m resolution DEMs, DSM predictions were five percentage points less accurate when using the more accurate DEM. The 5-m resolution was the most accurate DEM overall and resulted in DSM predictions with 44% accuracy; this value was equal to that obtained with two coarser resolution, lower accuracy DEMs. Thus, identifying the truly best DEM for DSM requires assessment of the accuracy of DSM predictions using some form of external validation, because not necessarily the most accurate DEM will produce the best DSM predictions.
DOI: 10.6084/m9.figshare.7678070
title: MODEL-BASED RUN-TO-RUN OPTIMIZATION FOR PROCESS DEVELOPMENT

description: Abstract Research and development of new processes is a fundamental part of any innovative industry. For process engineers, finding optimal operating conditions for new processes from the early stages is a main issue, since it improves economic viability, helps others areas of R&D by avoiding product bottlenecks and shortens the time-to-market period. Model-based optimization strategies are helpful in doing so, but imperfect models with parametric or structural errors can lead to suboptimal operating conditions. In this work, a methodology that uses probabilistic tendency models that are constantly updated through experimental feedback is proposed in order to rapidly and efficiently find improved operating conditions. Characterization of the uncertainty is used to make safe predictions even with scarce data, which is typical in this early stage of process development. The methodology is tested with an example from the traditional innovative pharmaceutical industry.
DOI: 10.6084/m9.figshare.7678073
title: C-PHYCOCYANIN PURIFICATION: MULTIPLE PROCESSES FOR DIFFERENT APPLICATIONS

description: Abstract C-phycocyanin is a potential nutraceutical/pharmaceutical candidate with functionalities that are better documented than those of health foods in general. Studies have demonstrated that C-phycocyanin has antioxidant and antitumor properties and potential activities against other diseases. However, its large-scale purification remains problematic and expensive. The aim of this work was to establish the best process for obtaining C-phycocyanin of different purities for different applications. The first step of this study was the maximization of the ultrafiltration process. Under the best ultrafiltration conditions, we evaluated the application of ultrafiltration, precipitation, and ion exchange chromatography (expanded and fixed beds) in different sequences and their effects on C-phycocyanin recovery and purification. It was possible to obtain C-phycocyanin that could be used as food dye with purity of 0.95 employing only diafiltration/ultrafiltration. With different process configurations, we obtained extracts that could be used as cosmetic dye with purity of 2.1 and biomarkers with purity of 3.0, and for therapeutic and biomedicine applications with an analytical grade (purity &gt; 4.0).
DOI: 10.6084/m9.figshare.7678076
title: Implementation of an Acute Coronary Syndrome Simulation Training Strategy for Emergency Healthcare Professionals

description: Abstract Background: The knowledge on the management of patients with acute coronary syndrome (ACS) is essential to reduce the gap between evidence and practice. Objective: To describe a simulation training strategy for emergency healthcare professionals and provide preliminary data on knowledge acquisition, learners' confidence and prescription of medications after training. Methods: The training was part of the implementation of two myocardial infarction systems of care. It comprehended lectures and simulation-based learning using high and low-fidelity mannequins and actors. It was tested in two phases: the first one in Belo Horizonte and the second one in Montes Claros, both in the state of Minas Gerais. A test was applied before and after training to assess knowledge acquisition. Confidence to perform thrombolysis in ST-elevation myocardial infarction (STEMI) patients was assessed using a questionnaire, and the impact on medication prescription analyzed STEMI patients admitted to hospitals in Montes Claros. Results: In the first phase, 156 professionals answered both tests: 70% of them improved their results and the median number of right answers increased (6, interquartile range [IQR] 5-7; vs 7 ([IQR] 6-9; p &lt; 0.05). In the second phase, 242 professionals answered both tests: 58% of the physicians and 83% of the nurses obtained better test scores. Participants referred a positive impact on their clinical practice, 95% reported feeling very secure when perform fibrinolysis after the training, and there was also an impact on medication prescription. Conclusions: There was an impact on the learners' knowledge acquisition and confidence using our two-phase training model, with evidence of impact on performance.
DOI: 10.6084/m9.figshare.7678064
title: Effect of brine and dry salting methods on the physicochemical and microbial quality of chub (Squalius cephalus Linnaeus, 1758)

description: Abstract The present study, looks at the physicochemical and microbiological quality changes that occur due to different salting techniques (20% salt concentration) of chub (Squalius cephalus) and when stored in 4 ± 0.5 °C. Samples of fish from each group was taken on the 15, 30, 45, 60, 90 and 120th day and was analyzed for nutritional component (crude protein, lipid, moisture, crude ash), pH value, salt content and the microbial flora (total mesophilic aerobic bacteria count, total coliform, total psychrophilic aerobic bacteria count, yeast and mould). It was determined that crude protein, lipid, crude ash and salt amounts in the group where dry salting method was applied were higher than the group where brine salting occurred, in addition protein and lipid values decreased as storage period was longer (P &lt; 0.05). It was determined that there is an increase in total aerobic mesophilic, psycrophile bacteria and enumeration of yeast and mould as storage period increased, while coliform bacteria decreased (P &lt; 0.05).
DOI: 10.6084/m9.figshare.7678073.v1
title: C-PHYCOCYANIN PURIFICATION: MULTIPLE PROCESSES FOR DIFFERENT APPLICATIONS

description: Abstract C-phycocyanin is a potential nutraceutical/pharmaceutical candidate with functionalities that are better documented than those of health foods in general. Studies have demonstrated that C-phycocyanin has antioxidant and antitumor properties and potential activities against other diseases. However, its large-scale purification remains problematic and expensive. The aim of this work was to establish the best process for obtaining C-phycocyanin of different purities for different applications. The first step of this study was the maximization of the ultrafiltration process. Under the best ultrafiltration conditions, we evaluated the application of ultrafiltration, precipitation, and ion exchange chromatography (expanded and fixed beds) in different sequences and their effects on C-phycocyanin recovery and purification. It was possible to obtain C-phycocyanin that could be used as food dye with purity of 0.95 employing only diafiltration/ultrafiltration. With different process configurations, we obtained extracts that could be used as cosmetic dye with purity of 2.1 and biomarkers with purity of 3.0, and for therapeutic and biomedicine applications with an analytical grade (purity &gt; 4.0).
DOI: 10.6084/m9.figshare.7678076.v1
title: Implementation of an Acute Coronary Syndrome Simulation Training Strategy for Emergency Healthcare Professionals

description: Abstract Background: The knowledge on the management of patients with acute coronary syndrome (ACS) is essential to reduce the gap between evidence and practice. Objective: To describe a simulation training strategy for emergency healthcare professionals and provide preliminary data on knowledge acquisition, learners' confidence and prescription of medications after training. Methods: The training was part of the implementation of two myocardial infarction systems of care. It comprehended lectures and simulation-based learning using high and low-fidelity mannequins and actors. It was tested in two phases: the first one in Belo Horizonte and the second one in Montes Claros, both in the state of Minas Gerais. A test was applied before and after training to assess knowledge acquisition. Confidence to perform thrombolysis in ST-elevation myocardial infarction (STEMI) patients was assessed using a questionnaire, and the impact on medication prescription analyzed STEMI patients admitted to hospitals in Montes Claros. Results: In the first phase, 156 professionals answered both tests: 70% of them improved their results and the median number of right answers increased (6, interquartile range [IQR] 5-7; vs 7 ([IQR] 6-9; p &lt; 0.05). In the second phase, 242 professionals answered both tests: 58% of the physicians and 83% of the nurses obtained better test scores. Participants referred a positive impact on their clinical practice, 95% reported feeling very secure when perform fibrinolysis after the training, and there was also an impact on medication prescription. Conclusions: There was an impact on the learners' knowledge acquisition and confidence using our two-phase training model, with evidence of impact on performance.