DOI: 10.5281/zenodo.18195473
title: Dataset for article: HPMA polymers as functional excipients in dermal nanoformulations of imiquimod; including the article in pdf

description: Dataset for article: HPMA polymers as functional excipients in dermal nanoformulations of imiquimod

 

Last updated: 2026-01-09

DOI:  10.5281/zenodo.18195473

 

______Contact______

* Eliska Kurfirtova       

* petrovai@vscht.cz

* +420 220 44 4188

* ORCID: 0000-0003-0691-8667

* Dept. of Organic Technology. Faculty of Chemical Technology, University of Chemistry and Technology, Prague

* Technicka 5, 166 28, Prague 6, Czech Republic

 

______Principal Investigator______

* Jarmila Zbytovska

* zbytovsj@vscht.cz

* +420 220 44 4223

* ORCID: 0000-0003-1541-8488

* Dept. of Organic Technology. Faculty of Chemical Technology, University of Chemistry and Technology, Prague

* Technicka 5, 166 28, Prague 6, Czech Republic

 

______Data manager or custodian______

* Aneta Kalvodova

* vovesnaa@vscht.cz

* +420 220 44 4188

* ORCID: 0000-0002-4224-4340

* Dept. of Organic Technology. Faculty of Chemical Technology, University of Chemistry and Technology, Prague

* Technicka 5, 166 28, Prague 6, Czech Republic

 

______Licence______   

*Dataset for HPMA polymers as functional excipients in dermal nanoformulations of imiquimod  article by Eliska Kurfirtova is licensed under CC BY 4.0

*licence information: https://creativecommons.org/licenses/by/4.0/

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______About the dataset______

 

The article focused on the p(HPMA) interaction with the skin barrier, specifically within the stratum corneum (SC), which was studied by confocal microscopy.

FTIR analysis confirmed that the polymers increase SC hydration without disrupting lipid organization.

As demonstrated by the ex vivo skin permeation study, the smallest p(HPMA) polymer (5 kg/mol) produced the strongest enhancement effect on IMQ delivery into skin tissue.

 

______Methods of data collection______

*TEWL

HW: Aquaflux AF200 (Biox Systems Ltd., UK)

Acquisition: minimal acquisition time 30s

*FTIR

HW: iZ10 (ThermoFisher, USA) with ZnSe ATR crystal (ThermoFisher, USA)

   acquisition: 64 scans, 2 cm^-1 resolution

*Permeation experiments

HW: Franz diffusion cells, Thermostated water bath, 60 position mixer (2mag AG, Germany)

*DLS

   HW: Zetasizer Nano ZS (Malwern Instruments, UK)

   Acquisition: Number od runs: 3, number of scans: 5

*TEM

HW: Jeol JEM-1010, Jeol Ltd., Tokyo, Japan

Acquisition: accelerating voltage: 80 kV

*Confocal microscopy

HW: Olympus Fluoview FV1000, using UPLFLN 20x objective, Tokyo, Japan

Acquisition: a laser (λ = 488 nm). The used laser strength was 2%

*HPLC

HW: Prominence LC-20 HPLC (Shimadzu, Tokyo, Japan) equipped with following: reverse-phase column Kinetex® (150 × 4.6 mm, 5 µm, RP C18, 100 Å) (Phenomenex, Torrance, USA); LC-20AD solvent delivery module with DGU-20A degasser; SIL-20AC autosampler; CTO-20AC column oven; SPD-M20A UV/VIS photodiode array detector; CBM-20A communication module

*Electrical impedance

HW: multimeter LCR 4080 (Voltcraft, Germany)

Acquisition: parallel-equivalent mode with an alternating current frequency of 120 Hz

 

______Methods of data processing______

The FTIR spectra were normalized [0,1] in OriginPro SW using inbuilt normalize function.

The exact peak position was evaluated in OriginPro SW using Find Peak function.

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______File name structure_____

Example: GACR_HPMA_260107_data summary

 

* RP_XX_YYMMDD_X_Z_000

     RP – research proposal

     XX – article identifier 

     YYMMDD – date of data creation

     X – type of data

     Z – measurement details

     000 – order of the files in the dataset

______File formats______

* Tabular, TEWL, FTIR, DLS data – converted to ASC

______SW necessary to open files______

* CSV and ASC files can be opened in text editors or Excel (Microsoft, USA)

______Date formats______

* YYYY-MM-DD

* HH-MM-SS 24hr format

______Units and abbreviations______

* TEWL data are in (g/m^2/h)

* Transdermal permeation and dermal entrapment are in (microg/cm^2)

* DLS particle sizes are in (nm) and PDI (-)

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______Dataset structure and List of files______

* Summary of data

GACR_HPMA_260107_data summary.csv