cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5128552.v1
title: Supplementary Material for: Angiotensin Converting Enzyme Inhibitor Dialyzability and Outcomes in Older Patients Receiving Hemodialysis

description: <b><i>Background/Aims:</i></b> Some angiotensin converting enzyme (ACE) inhibitors are efficiently removed from circulation by hemodialysis (‘high dialyzability'), whereas others are not (‘low dialyzability'). In patients receiving hemodialysis, this may influence the effectiveness of ACE inhibitors. <b><i>Methods:</i></b> Using linked healthcare databases we identified older patients receiving chronic hemodialysis who filled new ACE inhibitor prescriptions. The low dialyzability group (n = 3,369) included fosinopril and ramipril. The high dialyzability group (n = 5,974) included enalapril, lisinopril, and perindopril. The primary outcome was all-cause mortality within 180 days of first ACE inhibitor prescription. <b><i>Results:</i></b> There were 361 deaths among 5,974 patients (6.0%) prescribed with low dialyzability ACE inhibitors and 179 deaths among 3,369 patients (5.3%) prescribed with high dialyzability ACE inhibitors (relative risk 1.1, 95% CI 0.9-1.3, p = 0.6). <b><i>Conclusion:</i></b> In this study of older patients receiving hemodialysis, the dialyzability of ACE inhibitors was not associated with mortality or cardiovascular outcomes.
DOI: 10.6084/m9.figshare.5128537
title: Supplementary Material for: Microparticles from Patients with the Acute Coronary Syndrome Impair Vasodilatation by Inhibiting the Akt/eNOS-Hsp90 Signaling Pathway

description: <b><i>Objectives:</i></b> Endothelial dysfunction is involved in the development of the acute coronary syndrome (ACS). Plasma microparticles (MPs) from other diseases have been demonstrated to initiate coagulation and endothelial dysfunction. However, whether MPs from ACS patients impair vasodilatation and endothelial function remains unclear. <b><i>Methods:</i></b> Patients (n = 62) with ACS and healthy controls (n = 30) were recruited for MP isolation. Rat thoracic aortas were incubated with MPs from ACS patients or healthy controls to determine the effects of MPs on endothelial-dependent vasodilatation, the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS), the interaction of eNOS with heat shock protein 90 (Hsp90), and nitric oxide (NO) and superoxide anion (O<sub>2</sub><sup>-</sup>) production. The origin of MPs was assessed by flow cytometry. <b><i>Results:</i></b> MP concentrations were increased in patients with ACS compared with healthy controls. They were positively correlated with the degree of coronary artery stenosis. MPs from ACS patients impair endothelial-dependent vasodilatation, decrease both Akt and eNOS phosphorylation, decrease the interaction between eNOS and Hsp90, and decrease NO production but increase O<sub>2</sub><sup>-</sup> generation in rat thoracic aortas. Endothelial-derived MPs and platelet-derived MPs made up nearly 75% of MPs. <b><i>Conclusions:</i></b> Our data indicate that MPs from ACS patients negatively affect endothelial-dependent vasodilatation via Akt/eNOS-Hsp90 pathways.
DOI: 10.6084/m9.figshare.5128540
title: Supplementary Material for: Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness

description: Robust statistical, genetic and functional evidence supports a role for <i>DISC1</i> in the aetiology of major mental illness. Furthermore, many of its protein-binding partners show evidence for involvement in the pathophysiology of a range of neurodevelopmental and psychiatric disorders. Copy number variants (CNVs) are suspected to play an important causal role in these disorders. In this study, CNV analysis of <i>DISC1</i> and its binding partners <i>PAFAH1B1</i>, <i>NDE1</i>, <i>NDEL1</i>, <i>FEZ1</i>, <i>MAP1A</i>, <i>CIT</i> and <i>PDE4B</i> in Scottish and Northern Swedish population-based samples was carried out using multiplex amplicon quantification. Here, we report the finding of rare CNVs in <i>DISC1</i>, <i>NDE1</i> (together with adjacent genes within the 16p13.11 duplication), <i>NDEL1</i> (including the overlapping <i>MYH10 </i>gene) and <i>CIT</i>. Our findings provide further evidence for involvement of <i>DISC1</i> and its interaction partners in neuropsychiatric disorders and also for a role of structural variants in the aetiology of these devastating diseases.
DOI: 10.6084/m9.figshare.5128543
title: Supplementary Material for: Herbalists of Today's Switzerland and Their Plant Knowledge. A Preliminary Analysis from an Ethnobotanical Perspective

description: <b><i>Background:</i></b> Herbal medicine is a popular part of primary health care in Switzerland. Following an ethnobotanical approach, in this study we seek to identify Swiss herbalists with broad, empirical medicinal plant knowledge and use. We aim to consider different areas of the medicinal landscape including biomedicine, complementary and alternative medicine, and self-medication. <b><i>Material and Methods:</i></b> A total of 61 expert interviews were conducted from February 2010 to November 2011. The transfer of knowledge was analyzed according to a Switzerland-related selection of historical and recent popular as well as scientific herbal books. <b><i>Results:</i></b> A total of 254 medicinal plant species, belonging to 218 genera and 87 families, were recorded in 934 use reports. Predominantly leaves and flowers are used for the treatment of dermatological, respiratory, nervous, and gastrointestinal problems. Recent to historical herbal books are an important source of plant knowledge. <b><i>Conclusions: </i></b>Medicinal plants are used for self-medication and professional health care and despite different underlying medicinal concepts and philosophies, herbalists largely agree on the most important medicinal plant species.
DOI: 10.6084/m9.figshare.5128546
title: Supplementary Material for: The Conundrum of Papillary Breast Lesions within the C3 Category

description: <b><i>Objectives:</i></b> To identify features that could define papillary ductal cell proliferation within the C3 category and to subcategorise papillary lesions into benign papillomas which can be managed conservatively and atypical/malignant papillary neoplasms which require surgical intervention. <b><i>Study Design:</i></b> A blind microscopic rescreen of all C3 cases was conducted. The corresponding histological outcome was compared with the cytology. Statistical analysis was performed using papillary versus non-papillary outcomes and benign versus atypical/malignant papillary lesions. In addition, macropapillary lesions (papilloma and encysted papillary carcinoma) were plotted against micropapillary ductal carcinoma in situ. <b><i>Results:</i></b> Two hundred thirty FNA cases reported as C3 included 72 papillary neoplasms (52 benign papillomas and 20 atypical/malignant papillary lesions). Features specific to papillary lesions within C3 include macropapillary fragments, complex sheets, palisading strips, cystic background, cohesion and a decreased nuclear-to-cytoplasmic ratio. Features favouring atypical/malignant papillary lesions include decreased numbers of bare bipolar nuclei, discohesion and a non-cystic background. These features are common to most breast malignancies; however, identification of papillary features often results in a downgraded diagnosis from C5. <b><i>Conclusions:</i></b> This study supports the ability to reliably identify papillary ductal cell proliferation within C3. Certain features can distinguish papillary lesions from other C3 pathologies. This separation is likely to be clinically useful as papillary lesions may require a different management approach.
DOI: 10.6084/m9.figshare.5128549
title: Supplementary Material for: Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study

description: <b><i>Background:</i></b> The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. <b><i>Methods:</i></b> A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. <b><i>Results:</i></b> During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). <b><i>Conclusion:</i></b> Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.
DOI: 10.6084/m9.figshare.5128543.v1
title: Supplementary Material for: Herbalists of Today's Switzerland and Their Plant Knowledge. A Preliminary Analysis from an Ethnobotanical Perspective

description: <b><i>Background:</i></b> Herbal medicine is a popular part of primary health care in Switzerland. Following an ethnobotanical approach, in this study we seek to identify Swiss herbalists with broad, empirical medicinal plant knowledge and use. We aim to consider different areas of the medicinal landscape including biomedicine, complementary and alternative medicine, and self-medication. <b><i>Material and Methods:</i></b> A total of 61 expert interviews were conducted from February 2010 to November 2011. The transfer of knowledge was analyzed according to a Switzerland-related selection of historical and recent popular as well as scientific herbal books. <b><i>Results:</i></b> A total of 254 medicinal plant species, belonging to 218 genera and 87 families, were recorded in 934 use reports. Predominantly leaves and flowers are used for the treatment of dermatological, respiratory, nervous, and gastrointestinal problems. Recent to historical herbal books are an important source of plant knowledge. <b><i>Conclusions: </i></b>Medicinal plants are used for self-medication and professional health care and despite different underlying medicinal concepts and philosophies, herbalists largely agree on the most important medicinal plant species.
DOI: 10.6084/m9.figshare.5128528
title: Supplementary Material for: Small Supernumerary Marker Chromosomes in Human Infertility

description: Small supernumerary marker chromosomes (sSMC) are structurally abnormal chromosomes that cannot be unambiguously identified by banding cytogenetics. The objective of this study was to provide an overview of sSMC frequency and characterization in a context of infertility and to review the literature describing sSMC in relation with male and female infertility. Therefore, a systematic literature review on sSMC associated with infertility was conducted by means of a PubMed literature and a sSMC database (http://ssmc-tl.com/sSMC.html) search. A total of 234 patients with infertility were identified as carriers of sSMC. All chromosomes, except chromosomes 10, 19 and the X, were involved in sSMC, and in 72% the sSMC originated from acrocentric chromosomes. Euchromatic imbalances were caused by the presence of sSMC in 30% of the cases. Putative genes have been identified in only 1.2% of sSMC associated with infertility. The implication of sSMC in infertility could be due to a partial trisomy of some genes but also to mechanical effects perturbing meiosis. Further precise molecular and interphase-architecture studies on sSMC are needed in the future to characterize the relationship between this chromosomal anomaly and human infertility.
DOI: 10.6084/m9.figshare.5128531
title: Supplementary Material for: A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

description: <b><i>Background:</i></b> To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. <b><i>Methods:</i></b> All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. <b><i>Results:</i></b> We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p &lt; 0.01). <b><i>Conclusions:</i></b> In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.
DOI: 10.6084/m9.figshare.5128534
title: Supplementary Material for: Lateral Transorbital Endoscopic Access to the Hippocampus, Amygdala, and Entorhinal Cortex: Initial Clinical Experience

description: <b><i>Background/Aims:</i></b> Transorbital approaches traditionally have focused on skull base and cavernous sinus lesions medial to the globe. Lateral orbital approaches to the temporal lobe have not been widely explored despite several theoretical advantages compared to open craniotomy. Recently, we demonstrated the feasibility of the lateral transorbital technique in cadaveric specimens with endoscopic visualization. We describe our initial clinical experience with the endoscope-assisted lateral transorbital approach to lesions in the temporal lobe. <b><i>Methods:</i></b> Two patients with mesial temporal lobe pathology presenting with seizures underwent surgery. The use of a transpalpebral or Stallard-Wright eyebrow incision enabled access to the intraorbital compartment, and a lateral orbital wall ‘keyhole' opening permitted visualization of the anterior temporal pole. <b><i>Results:</i></b> This approach afforded adequate access to the surgical target and surrounding structures and was well tolerated by the patients. To the best of our knowledge, this report constitutes the first case series describing the endoscope-assisted lateral transorbital approach to the temporal lobe. We discuss the limits of exposure, the nuances of opening and closing, and comparisons to open craniotomy. <b><i>Conclusion:</i></b> Further prospective investigation of this approach is warranted for comparison to traditional approaches to the mesial temporal lobe.
DOI: 10.6084/m9.figshare.5128537.v1
title: Supplementary Material for: Microparticles from Patients with the Acute Coronary Syndrome Impair Vasodilatation by Inhibiting the Akt/eNOS-Hsp90 Signaling Pathway

description: <b><i>Objectives:</i></b> Endothelial dysfunction is involved in the development of the acute coronary syndrome (ACS). Plasma microparticles (MPs) from other diseases have been demonstrated to initiate coagulation and endothelial dysfunction. However, whether MPs from ACS patients impair vasodilatation and endothelial function remains unclear. <b><i>Methods:</i></b> Patients (n = 62) with ACS and healthy controls (n = 30) were recruited for MP isolation. Rat thoracic aortas were incubated with MPs from ACS patients or healthy controls to determine the effects of MPs on endothelial-dependent vasodilatation, the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS), the interaction of eNOS with heat shock protein 90 (Hsp90), and nitric oxide (NO) and superoxide anion (O<sub>2</sub><sup>-</sup>) production. The origin of MPs was assessed by flow cytometry. <b><i>Results:</i></b> MP concentrations were increased in patients with ACS compared with healthy controls. They were positively correlated with the degree of coronary artery stenosis. MPs from ACS patients impair endothelial-dependent vasodilatation, decrease both Akt and eNOS phosphorylation, decrease the interaction between eNOS and Hsp90, and decrease NO production but increase O<sub>2</sub><sup>-</sup> generation in rat thoracic aortas. Endothelial-derived MPs and platelet-derived MPs made up nearly 75% of MPs. <b><i>Conclusions:</i></b> Our data indicate that MPs from ACS patients negatively affect endothelial-dependent vasodilatation via Akt/eNOS-Hsp90 pathways.
DOI: 10.6084/m9.figshare.5128525
title: Supplementary Material for: Versorgung Zwangserkrankter mit kognitiver Verhaltenstherapie als Behandlungsmethode erster Wahl

description: <b><i>Hintergrund: </i></b>Die kognitive Verhaltenstherapie (KVT) mit Exposition und Reaktionsverhinderung stellt die Behandlungsmethode erster Wahl für Patienten mit Zwangsstörung dar. Ziel der vorliegenden Studie war die Bestimmung des Anteils an Patienten mit einer Zwangsstörung, die in Deutschland eine KVT mit Exposition und Reaktionsverhinderung erhalten. <b><i>Methode: </i></b>Hierzu wurden die Daten aus einer Befragung zur Behandlungsvorgeschichte einer Stichprobe von 369 Patienten mit einer Zwangsstörung nach ICD-10 analysiert. <b><i>Ergebnisse: </i></b>Insgesamt berichteten 60% der Patienten, in ihrer Behandlungsvorgeschichte mindestens einmal eine KVT mit Expositionsübungen erhalten zu haben. Bei 37% war dies die erste Behandlung. 46% gaben an, mindestens einmal eine KVT mit therapeutenbegleiteten Expositionsübungen erhalten zu haben. Durchschnittlich vergingen 6 Jahre zwischen Beginn der Zwangsstörung und Beginn der ersten Behandlung. <b><i>Schlussfolgerungen: </i></b>Zwei Fünftel der Patienten unserer Stichprobe berichteten, dass sie noch nie eine KVT mit Exposition und Reaktionsverhinderung erhalten hatten, obwohl es sich dabei um die Methode erster Wahl bei Zwangsstörungen handelt. Wir diskutieren potenzielle Hürden aufseiten der Patienten, Ärzte und Therapeuten sowie Maßnahmen, die zur Verbesserung der Versorgungssituation beitragen könnten.
DOI: 10.6084/m9.figshare.5128531.v1
title: Supplementary Material for: A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

description: <b><i>Background:</i></b> To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. <b><i>Methods:</i></b> All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. <b><i>Results:</i></b> We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p &lt; 0.01). <b><i>Conclusions:</i></b> In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.
DOI: 10.6084/m9.figshare.5128516
title: Supplementary Material for: Effectiveness of a Web-Based Cognitive Behavioural Intervention for Subthreshold Depression: Pragmatic Randomised Controlled Trial

description: <b><i>Background:</i></b> Research on the effectiveness of treatments for subthreshold depression (sD) is still scarce. The aim of the study was to evaluate the efficacy of a web-based guided self-help intervention (GET.ON Mood Enhancer) in the treatment of sD. <b><i>Methods:</i></b> Participants with sD (n = 406) recruited from the general population via a large health insurance company were randomly allocated to a web-based cognitive behavioural intervention or to enhanced care-as-usual. The primary outcome was the reduction in depressive symptom severity as measured with the Center for Epidemiological Studies Depression Scale at post-treatment and at 6-month follow-up. <b><i>Results:</i></b> Participants in the intervention group showed a significantly greater pre-post reduction in depressive symptom severity (d = 1.06; 95% CI: 0.86-1.27) compared to the control condition (d = 0.29; 95% CI: 0.10-0.49). The corresponding between-group effect size was d = 0.69 (95% CI: 0.49-0.89). At 6-month follow-up the effect was reduced to d = 0.28 (95% CI: 0.09-0.48) but was still statistically significant (F<sub>1, 403</sub> = 9.240, p = 0.003). <b><i>Conclusions:</i></b> This study lends support to the idea that problem solving coupled with behavioural activation is an effective treatment for sD. In addition, the delivery of this intervention over the Internet might be a promising strategy for the dissemination of psychological interventions for sD on a large scale.
DOI: 10.6084/m9.figshare.5128519
title: Supplementary Material for: Model for Predicting Cardiovascular Disease: Insights from a Korean Cardiovascular Risk Model

description: The profile and prevalence of risk factors in cardiovascular disease (CVD) are different between Western and Asian populations. In the guidelines, tailored approaches following risk stratification based on CVD risk models are recommended for the primary prevention of CVD in asymptomatic subjects. However, current risk models for predicting CVD in Asian populations are limited. A recent study of a large cohort of asymptomatic Korean individuals developed a CVD risk model to predict global cardiovascular risk that showed good performance in predicting cardiovascular events. This model may be useful for the primary prevention of CVD in East Asian individuals as well as Koreans.