cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6871076.v2
title: Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses

description: Genomic imprinting is an epigenetic phenomenon of differential allelic expression based on parental origin. To date, 263 imprinted genes have been identified among all investigated mammalian species. However, only 21 have been described in sheep, of which 11 are annotated in the current ovine genome. Here, we aim to i) use DNA/RNA high throughput sequencing to identify new monoallelically expressed and imprinted genes in day 135 ovine fetuses and ii) determine whether maternal diet (100%, 60%, or 140% of National Research Council Total Digestible Nutrients) influences expression of imprinted genes. We also reported strategies to solve technical challenges in the data analysis pipeline. We identified 80 monoallelically expressed, 13 new putative imprinted genes, and five known imprinted genes in sheep using the 263 genes stated above as a guide. Sanger sequencing confirmed allelic expression of seven genes, <i>CASD1, COPG2, DIRAS3, INPP5F, PLAGL1, PPP1R9A</i>, and <i>SLC22A18</i>. Among the 13 putative imprinted genes, five were localized in the known sheep imprinting domains of <i>MEST</i> on chromosome 4, <i>DLK1/GTL2</i> on chromosome 18 and <i>KCNQ1</i> on chromosome 21, and three were in a novel sheep imprinted cluster on chromosome 4, known in other species as <i>PEG10/SGCE</i>. The expression of <i>DIRAS3, IGF2, PHLDA2</i>, and <i>SLC22A18</i> was altered by maternal diet, albeit without allelic expression reversal. Together, our results expanded the list of sheep imprinted genes to 34 and demonstrated that while the expression levels of four imprinted genes were changed by maternal diet, the allelic expression patterns were un-changed for all imprinted genes studied.
DOI: 10.7910/dvn/1t8n3n/w4g2pu
title: 1V-16

description: sigma=1volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/g1vazd
title: 1V-35

description: sigma=1volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/buibc0
title: 1V-51

description: sigma=1volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/4hr5cg
title: 1V-58

description: sigma=1volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/08inc2
title: 1V-53

description: sigma=1volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/evs3ih
title: 1V-36

description: sigma=1volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/p7ghfn
title: 1-13.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/ya10zg
title: 1-18.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/0rtz5h
title: 1-23.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/vxa9wf
title: 1-8.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/1z3yb6
title: 1-17.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/fqbnc3
title: 1-21.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/7mrpoo
title: 1-7.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/du3uol
title: 1-15.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/wrneol
title: 1-41.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/tpcq70
title: 1-35.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/h9bwxk
title: 1-46.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/wqgfjs
title: 1-44.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/jthyop
title: 1-47.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/fod0ev
title: 1-40.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/v9nts2
title: 1-43.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/wa9c3w
title: 1-30.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/29srbx
title: 1-11.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/q86dog
title: 1-27.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/0dfigi
title: 1-48.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/un3s0m
title: 1-25.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/qzorfk
title: 1-33.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/33jubf
title: 1-34.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/pg0ja4
title: 1-19.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/g5anxg
title: 1.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/qbm6zf
title: A revision of the species of the Neoserica (sensu lato) vulpes group (Coleoptera: Scarabaeidae: Sericini)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Ahrens, Dirk, Liu, Wangang, Fabrizi, Silvia, Bai, Ming, Yang, Xing-Ke (2014): A revision of the species of the Neoserica (sensu lato) vulpes group (Coleoptera: Scarabaeidae: Sericini). Journal of Natural History 49 (17): 1073-1130, DOI: 10.1080/00222933.2014.974707
DOI: 10.7910/dvn/1t8n3n/i3alp2
title: 1-28.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/ijwb5b
title: 1-22.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/e7k568
title: 1-42.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/g67ww4
title: Intraspecific larval aggression in two species of Hyperini (Coleoptera: Curculionidae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Skuhrovec, Jiří, Štys, Pavel, Exnerová, Alice (2014): Intraspecific larval aggression in two species of Hyperini (Coleoptera: Curculionidae). Journal of Natural History 49 (19): 1131-1146, DOI: 10.1080/00222933.2014.974704
DOI: 10.7910/dvn/1t8n3n/yv1y1r
title: 1-37.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/c854p7
title: A new genus with two new species of mesosciophilids from the Middle Jurassic of China (Diptera: Nematocera: Mesosciophilidae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Shi, GuiFeng, Shih, ChungKun, Ren, Dong (2014): A new genus with two new species of mesosciophilids from the Middle Jurassic of China (Diptera: Nematocera: Mesosciophilidae). Journal of Natural History 49 (19): 1147-1158, DOI: 10.1080/00222933.2014.951085
DOI: 10.7910/dvn/1t8n3n/declrk
title: 1-9.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/vrrtyn
title: 1-5.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/bzd5fe
title: Classification, Natural History, and Evolution of the Subfamily Peloniinae O (Coleoptera: Cleroidea: Cleridae). Part IX. Taxonomic revision of the New World genus Muisca S

description: This dataset contains the digitized treatments in Plazi based on the original journal article Opitz, Pitz Pinola Weston (2018): Classification, Natural History, and Evolution of the Subfamily Peloniinae O (Coleoptera: Cleroidea: Cleridae). Part IX. Taxonomic revision of the New World genus Muisca S. Linzer biologische Beiträge 50 (1): 587-653, DOI: http://doi.org/10.5281/zenodo.4004283
DOI: 10.7910/dvn/1t8n3n/wwn2fa
title: 1-16.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/w6j9cx
title: A catalogue of the family Andrenidae (Hymenoptera: Apoidea) of Eritrea

description: This dataset contains the digitized treatments in Plazi based on the original journal article Madl, Michael (2018): A catalogue of the family Andrenidae (Hymenoptera: Apoidea) of Eritrea. Linzer biologische Beiträge 50 (1): 655-659, DOI: http://doi.org/10.5281/zenodo.4004346
DOI: 10.7910/dvn/1t8n3n/doqfyj
title: 1-32.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/fzlqdg
title: 1-1.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/jgbpk4
title: 1-51.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/flmmgc
title: 1-3.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/6gus8w
title: 1-36.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/1t8n3n/4mo6iy
title: 1-39.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.17637/rh.6870908
title: Fenix Chico Master Varve Chronology (2017)

description: This fileset includes the Fenix Chico Master Varve Chronology (FCMC17), and the geochemistry (major- and trace-element) of the Ho tephra layer from Hudson volcano (cf. Bendle et al. 2017). The FCMC17 is a composite, and calendar-year, varve chronology derived from the correlation of five independent site varve records from the Lago General Carerra-Buenos Aires basin (46.5°S) in central Patagonia (southern South America).
DOI: 10.7910/dvn/1t8n3n/fxm8fc
title: 1-14.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/hjb3a6
title: Description of Orthadenella coulsoni sp. nov. (Acari: Mesostigmata: Melicharidae) from Siberia with a key to the females of Orthadenella

description: This dataset contains the digitized treatments in Plazi based on the original journal article Gwiazdowicz, Dariusz J., Marchenko, Irina I., Teodorowicz, Ewa (2014): Description of Orthadenella coulsoni sp. nov. (Acari: Mesostigmata: Melicharidae) from Siberia with a key to the females of Orthadenella. Journal of Natural History 49 (27): 1659-1671, DOI: 10.1080/00222933.2014.974706
DOI: 10.17637/rh.6870908.v1
title: Fenix Chico Master Varve Chronology (2017)

description: This fileset includes the Fenix Chico Master Varve Chronology (FCMC17), and the geochemistry (major- and trace-element) of the Ho tephra layer from Hudson volcano (cf. Bendle et al. 2017). The FCMC17 is a composite, and calendar-year, varve chronology derived from the correlation of five independent site varve records from the Lago General Carerra-Buenos Aires basin (46.5°S) in central Patagonia (southern South America).
DOI: 10.7910/dvn/1t8n3n/ym4vzl
title: 1-10.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.6870866
title: Supplementary Material for: Trendelenburg Positioning in Large Vessel Ischaemic Stroke: A Pre-Post Observational Study Using Propensity Score Matching

description: <b><i>Background:</i></b> Along with pharmacological and mechanical recanalization, improving cerebral perfusion through the recruitment of collateral vessels during the acute phase of ischaemic stroke (IS) is a clinical challenge. Our objective was to assess the effectiveness and safety of Trendelenburg positioning (TP), a procedure intended to increase cerebral blood flow, on the outcome of IS. <b><i>Methods:</i></b> Two cohorts of patients with an acute supratentorial IS related to a large artery occlusion were compared. In the first cohort (<i>n</i> = 119), we used standard positioning (0 to +30°); in the second cohort (<i>n</i> = 90), we used TP (0 to –15°). The primary outcome measure was the improvement of National Institutes of Health Stroke Scale (NIHSS) score between admission and day 2. Factors associated with an improvement ≥4 points of NIHSS score were assessed using multiple logistic regression and propensity score (PS) matching analyses. <b><i>Results:</i></b> TP was significantly associated with a greater improvement of NIHSS score within 48 h following stroke onset (4.0 ± 5.7 vs. 1.8 ± 5.9, <i>p</i> = 0.011) but also at discharge (<i>p</i> = 0.005). Multiple logistic regression analysis suggested that TP was an independent predictor of early neurological improvement (adjusted OR 1.81, 95% CI 1.00–3.27) in a model controlling recanalization and haemoglobin level. In addition, PS matching analysis confirmed the possible effectiveness of TP (unadjusted OR 1.99, 95% CI 1.04–3.82), especially in male subjects. The effect of TP was more pronounced in patients with admission mean arterial blood pressure ≥100 mm Hg, those exhibiting a good collateral vessel network on admission CT-angiography or experiencing an effective recanalization. Furthermore, TP was not associated with life-threatening complications. <b><i>Conclusion:</i></b> TP could be an effective and safe strategy in patients with large IS resulting from the proximal occlusion of a large vessel.
DOI: 10.7910/dvn/1t8n3n/vxfn3o
title: 1-38.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.6870866.v1
title: Supplementary Material for: Trendelenburg Positioning in Large Vessel Ischaemic Stroke: A Pre-Post Observational Study Using Propensity Score Matching

description: <b><i>Background:</i></b> Along with pharmacological and mechanical recanalization, improving cerebral perfusion through the recruitment of collateral vessels during the acute phase of ischaemic stroke (IS) is a clinical challenge. Our objective was to assess the effectiveness and safety of Trendelenburg positioning (TP), a procedure intended to increase cerebral blood flow, on the outcome of IS. <b><i>Methods:</i></b> Two cohorts of patients with an acute supratentorial IS related to a large artery occlusion were compared. In the first cohort (<i>n</i> = 119), we used standard positioning (0 to +30°); in the second cohort (<i>n</i> = 90), we used TP (0 to –15°). The primary outcome measure was the improvement of National Institutes of Health Stroke Scale (NIHSS) score between admission and day 2. Factors associated with an improvement ≥4 points of NIHSS score were assessed using multiple logistic regression and propensity score (PS) matching analyses. <b><i>Results:</i></b> TP was significantly associated with a greater improvement of NIHSS score within 48 h following stroke onset (4.0 ± 5.7 vs. 1.8 ± 5.9, <i>p</i> = 0.011) but also at discharge (<i>p</i> = 0.005). Multiple logistic regression analysis suggested that TP was an independent predictor of early neurological improvement (adjusted OR 1.81, 95% CI 1.00–3.27) in a model controlling recanalization and haemoglobin level. In addition, PS matching analysis confirmed the possible effectiveness of TP (unadjusted OR 1.99, 95% CI 1.04–3.82), especially in male subjects. The effect of TP was more pronounced in patients with admission mean arterial blood pressure ≥100 mm Hg, those exhibiting a good collateral vessel network on admission CT-angiography or experiencing an effective recanalization. Furthermore, TP was not associated with life-threatening complications. <b><i>Conclusion:</i></b> TP could be an effective and safe strategy in patients with large IS resulting from the proximal occlusion of a large vessel.
DOI: 10.7910/dvn/1t8n3n/b5jado
title: 1-49.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.15468/ep2p7v
title: A catalogue of the families Argidae and Tenthredinidae (Hymenoptera: Symphyta: Tenthredinoidea) of Eritrea

description: This dataset contains the digitized treatments in Plazi based on the original journal article Madl, Michael (2018): A catalogue of the families Argidae and Tenthredinidae (Hymenoptera: Symphyta: Tenthredinoidea) of Eritrea. Linzer biologische Beiträge 50 (1): 665-670, DOI: http://doi.org/10.5281/zenodo.4004350
DOI: 10.15468/bgdede
title: Cranchiids of the South Atlantic Mid-Oceanic Ridge: results from the first southern MAR-ECO expedition

description: This dataset contains the digitized treatments in Plazi based on the original journal article Bolstad, K. S. R., Perez, J. A. A., Strugnell, J. M., Vidal, E. A. G. (2014): Cranchiids of the South Atlantic Mid-Oceanic Ridge: results from the first southern MAR-ECO expedition. Journal of Natural History 49 (21): 1351-1371, DOI: 10.1080/00222933.2013.867375
DOI: 10.7910/dvn/1t8n3n/jwjum2
title: 1-12.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.6870827
title: Supplementary Material for: Serum Uric Acid Levels as an Indicator for Metabolically Unhealthy Obesity in Children and Adolescents

description: <b><i>Background:</i></b> Metabolically healthy obesity (MHO) refers to those individuals who do not show cardiometabolic abnormalities. Our aim was to identify potential clinical and metabolic indicators that may help to distinguish between metabolically healthy and unhealthy individuals amongst overweight and obese children and adolescents. <b><i>Methods:</i></b> The study involved 246 overweight/obese and 212 normal-weight individuals enrolled in the LIFE Child study, aged between 6 and 18 years. Overweight/obese individuals without cardiovascular risk factors (fasting serum lipids, blood pressure, and glucose) were classified as MHO. Individuals meeting 1 or more criteria of cardiovascular risk factors were classified as metabolically unhealthy obesity (MUO). <b><i>Results:</i></b> Among the 246 overweight/obese individuals, 173 (70%) were MHO and 73 (30%) were MUO. The MHO individuals were younger, more likely to be male, and had lower BMI SDS. In the logistic regression models, uric acid (UA) SDS (OR 1.61, 95% CI 1.1–2.6, <i>p</i> = 0.004), waist circumference SDS (OR 2.50, 95% CI 1.2–6.4, <i>p</i> = 0.017), and C-peptide (OR 4.05, 95% CI 3.5–91, <i>p</i> = 0.003) were significant indicators of MUO. <b><i>Conclusion:</i></b> Our results suggest that nearly one-third of overweight/obese children are already identified as MUO. Serum levels of UA can be used as an indicator of unhealthy obesity in youth, where lower levels of UA indicate a lower risk and higher levels suggest a higher risk of MUO. We note that the relevance of identifying potential indicators remains the first most important step in future clinical research.
DOI: 10.7910/dvn/1t8n3n/jwzmr4
title: 1-6.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;