cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5242117.v1
title: Erratum: Quantitative Evaluation of Brain Stem Atrophy Using Magnetic Resonance Imaging in Adult Patients with Alexander Disease

description: Brain MRI in adult patients with Alexander disease (AxD) mainly shows atrophy in the medulla oblongata. However, currently there is no quantitative standard for assessing this atrophy. In this study, we quantitatively evaluated the brain stem of AxD patients with <i>glial fibrillary acidic protein (GFAP)</i> mutation using conventional MRI to evaluate its usefulness as an aid to diagnosing AxD in daily clinical practice. Nineteen AxD patients with <i>GFAP</i> mutation were compared with 14 patients negative for <i>GFAP</i> mutation in whom AxD was suspected due to “atrophy of the medulla oblongata.” In the <i>GFAP</i> mutation-positive group, the sagittal diameter of the medulla oblongata, the ratio of the diameter of the medulla oblongata to that of the midbrain (MO/MB), and the ratio of the sagittal diameter of the medulla oblongata to that of the pons (MO/Po) were significantly smaller compared to those of the <i>GFAP</i> mutation-negative group (<i>p</i> &lt; 0.01). The sensitivity and specificity of each parameter were 87.5 and 92.3%, 91.7 and 81.3%, and 88.2 and 100% with a sagittal diameter of the medulla oblongata &lt;9.0 mm, MO/MB &lt;0.60, and sagittal MO/Po &lt;0.46, respectively. These parameters can provide very useful information to differentially diagnose AxD from other disorders associated with brain stem atrophy in adult patients.
DOI: 10.6084/m9.figshare.5242105
title: Erratum: Predictors of BMI Vary along the BMI Range of German Adults - Results of the German National Nutrition Survey II

description: <b><i>Objective:</i></b> The objective of the study was to identify predictors of BMI in German adults by considering the BMI distribution and to determine whether the association between BMI and its predictors varies along the BMI distribution. <b><i>Methods:</i></b> The sample included 9,214 adults aged 18-80 years from the German National Nutrition Survey II (NVS II). Quantile regression analyses were conducted to examine the association between BMI and the following predictors: age, sports activities, socio-economic status (SES), healthy eating index-NVS II (HEI-NVS II), dietary knowledge, sleeping duration and energy intake as well as status of smoking, partner relationship and self-reported health. <b><i>Results:</i></b> Age, SES, self-reported health status, sports activities and energy intake were the strongest predictors of BMI. The important outcome of this study is that the association between BMI and its predictors varies along the BMI distribution. Especially, energy intake, health status and SES were marginally associated with BMI in normal-weight subjects; this relationships became stronger in the range of overweight, and were strongest in the range of obesity. <b><i>Conclusions:</i></b> Predictors of BMI and the strength of these associations vary across the BMI distribution in German adults. Consequently, to identify predictors of BMI, the entire BMI distribution should be considered.
DOI: 10.6084/m9.figshare.5242108
title: Erratum: Impact of PD-L1 Expression in Patients with Surgically Resected Non-Small-Cell Lung Cancer

description: <b><i>Background:</i></b> Immunotherapy can become a crucial therapeutic option to improve the prognosis of patients with non-small-cell lung cancer (NSCLC). Here, we evaluated the impact of programmed cell death ligand-1 (PD-L1) expression in surgically resected NSCLCs. <b><i>Methods:</i></b> We estimated PD-L1 expression in 229 consecutive NSCLC specimens using rabbit polyclonal antibodies to human PD-L1 in a SP263 immunohistochemical assay and evaluated PD-L1 expression for potential associations with clinicopathological parameters and survival time. <b><i>Results:</i></b> PD-L1 expression was significantly higher in tumors from men or current smokers. Squamous cell carcinoma histology was independently associated with high PD-L1 expression according to multivariate analysis (<i>p</i> = 0.015). The 5-year survival rate of patients was 70%, and the difference in the 5-year survival rate according to PD-L1 expression was not statistically significant (high expression group [67%] vs. low expression group [68%]); however, the squamous cell carcinoma group exhibited significantly lower 5-year survival rates as compared to the non-squamous cell carcinoma group (53 and 71%, respectively; <i>p</i> = 0.026). <b><i>Conclusion:</i></b> Here, we revealed high PD-L1 expression and poor prognosis observed in patients with surgically resected squamous NSCLC as compared with non-squamous NSCLC. Our results support the identification of patient subsets that most likely respond to anti-PD-1 therapy as the first step in precision medicine.
DOI: 10.6084/m9.figshare.5242132.v1
title: U–Pb–Hf isotopes and trace elements of metasomatic zircon delimit the evolution of neoproterozoic Capané ophiolite in the southern Brasiliano Orogen

description: The Capané ophiolite is a fragment of oceanic lithosphere obducted into the Ediacaran Porongos fold and thrust belt, southern Brasiliano Orogen. A studied rodingite blackwall contained in serpentinite has metasomatic zircon that displays multiple U–Pb ages from Tonian to Cryogenian (793 ± 0.9, 757 ± 2.1, 715 ± 2.2 Ma). The ages are interpreted as corresponding to multiple alteration events in the mantle. Multiple U–Pb–Hf isotopes and trace element analyses on the same crystals by laser ablation were controlled by backscatered electron images. Hf isotopes indicate zircon origin from a depleted mantle (<i>ε</i>Hf = +15 to +10.7), and trace elements point to an oceanic origin. The Capané ophiolite thus marks the evolution of the Adamastor ocean during the Tonian and Cryogenian, a significant result for the reconstruction of Rodinia and Gondwana supercontinents.
DOI: 10.6084/m9.figshare.5242114.v1
title: Erratum: Dermoscopy of Malignant Skin Tumours: What's New?

description: Dermoscopy represents a new and effective tool that assists dermatologists in improving the accuracy of clinical diagnosis in onco-dermatology. The aim of this article is to provide an overview of the latest and important dermoscopic progress and observations in this ever-evolving field of dermatology.
DOI: 10.6084/m9.figshare.5242105.v1
title: Erratum: Predictors of BMI Vary along the BMI Range of German Adults - Results of the German National Nutrition Survey II

description: <b><i>Objective:</i></b> The objective of the study was to identify predictors of BMI in German adults by considering the BMI distribution and to determine whether the association between BMI and its predictors varies along the BMI distribution. <b><i>Methods:</i></b> The sample included 9,214 adults aged 18-80 years from the German National Nutrition Survey II (NVS II). Quantile regression analyses were conducted to examine the association between BMI and the following predictors: age, sports activities, socio-economic status (SES), healthy eating index-NVS II (HEI-NVS II), dietary knowledge, sleeping duration and energy intake as well as status of smoking, partner relationship and self-reported health. <b><i>Results:</i></b> Age, SES, self-reported health status, sports activities and energy intake were the strongest predictors of BMI. The important outcome of this study is that the association between BMI and its predictors varies along the BMI distribution. Especially, energy intake, health status and SES were marginally associated with BMI in normal-weight subjects; this relationships became stronger in the range of overweight, and were strongest in the range of obesity. <b><i>Conclusions:</i></b> Predictors of BMI and the strength of these associations vary across the BMI distribution in German adults. Consequently, to identify predictors of BMI, the entire BMI distribution should be considered.
DOI: 10.6084/m9.figshare.5242108.v1
title: Erratum: Impact of PD-L1 Expression in Patients with Surgically Resected Non-Small-Cell Lung Cancer

description: <b><i>Background:</i></b> Immunotherapy can become a crucial therapeutic option to improve the prognosis of patients with non-small-cell lung cancer (NSCLC). Here, we evaluated the impact of programmed cell death ligand-1 (PD-L1) expression in surgically resected NSCLCs. <b><i>Methods:</i></b> We estimated PD-L1 expression in 229 consecutive NSCLC specimens using rabbit polyclonal antibodies to human PD-L1 in a SP263 immunohistochemical assay and evaluated PD-L1 expression for potential associations with clinicopathological parameters and survival time. <b><i>Results:</i></b> PD-L1 expression was significantly higher in tumors from men or current smokers. Squamous cell carcinoma histology was independently associated with high PD-L1 expression according to multivariate analysis (<i>p</i> = 0.015). The 5-year survival rate of patients was 70%, and the difference in the 5-year survival rate according to PD-L1 expression was not statistically significant (high expression group [67%] vs. low expression group [68%]); however, the squamous cell carcinoma group exhibited significantly lower 5-year survival rates as compared to the non-squamous cell carcinoma group (53 and 71%, respectively; <i>p</i> = 0.026). <b><i>Conclusion:</i></b> Here, we revealed high PD-L1 expression and poor prognosis observed in patients with surgically resected squamous NSCLC as compared with non-squamous NSCLC. Our results support the identification of patient subsets that most likely respond to anti-PD-1 therapy as the first step in precision medicine.
DOI: 10.6084/m9.figshare.5242111.v1
title: Erratum: Chronic Mesenteric Ischemia: Patient Outcomes Using Open Surgical Revascularization

description: <b><i>Background:</i></b> Chronic mesenteric ischemia (CMI) is a rare disease. Open treatment (OT) remains a valuable treatment option. We analyzed patient outcomes after OT and investigated health-related quality of life (HRQoL). <b><i>Methods:</i></b> Data were analyzed retrospectively. The investigation period was from January 1, 2001, to December 31, 2014. We investigated mortality and patency rates using Kaplan-Meier analysis. HRQoL was measured using a 36-item health survey. Various statistical methods were employed. <b><i>Results:</i></b> A total of 100 patients (celiac trunk [TC: <i>n</i> = 23], superior mesenteric artery [SMA: <i>n</i> = 26], or both [<i>n</i> = 51]) were included. Median follow-up was 5 ± 35 months. One-year survival rate for TC was 75 ± 11%, for SMA: 79 ± 10%, and for both: 96 ± 3%. TC 5-year survival was 75 ± 11% (SMA: 57 ± 16%: both: 80 ± 8%). Obesity and the length of hospital stay were independently associated with patient survival (<i>p</i> &lt; 0.05). Primary 1-year patency rate was 60 ± 13% for TC (SMA: 86 ± 10%; both: 71 ± 8%) and secondary 1-year patency rate was 84 ± 9% for TC (SMA: 100%; both: 79 ± 7%). HRQoL was inferior compared to the German normative data (<i>p</i> &lt; 0.05). <b><i>Conclusion:</i></b> CMI overlaps between gastrointestinal and vascular surgery. OT is safe, and simultaneous revascularization of the TC and the SMA does not affect mortality. Patients would not necessarily benefit from OT in terms of HRQoL.
DOI: 10.6084/m9.figshare.5242096
title: Erratum: Clinicopathological Features and Therapeutic Responses of Chinese Patients with Advanced Lung Adenocarcinoma Harboring an Anaplastic Lymphoma Kinase Rearrangement

description: <b><i>Background:</i></b> Presence of anaplastic lymphoma kinase (<i>ALK</i>) rearrangement is an indication for crizotinib in the treatment of patients with advanced or metastatic lung adenocarcinoma. Here, we sought to elucidate the association between clinicopathological features and <i>ALK</i> rearrangement status in Chinese patients with advanced lung adenocarcinoma harboring an <i>ALK</i> rearrangement. <b><i>Patients and Methods:</i></b><i>ALK</i> rearrangement status was determined using immunohistochemistry (IHC) in tumor tissues from 120 patients with advanced lung adenocarcinoma, and further assessed by fluorescence in situ hybridization (FISH) assay. The associations between <i>ALK</i> rearrangement status and clinicopathological features were analyzed. <b><i>Results:</i></b> According to IHC testing, the <i>ALK</i>-positive rate among the advanced lung adenocarcinoma patients was 6.67% (8/120). FISH validation found 5 patients with <i>ALK</i> rearrangement among the 8 IHC-positive cases. No significant difference was observed regarding age, sex, or smoking status between FISH-positive and -negative patients (p &gt; 0.05). None of the 5 FISH-positive patients benefited from first-line chemotherapy. <b><i>Conclusion:</i></b> IHC can be used as a reliable method for <i>ALK</i> rearrangement screening in patients with lung adenocarcinoma, but further FISH validation is imperative. Presence of <i>ALK</i> rearrangement predicts a more aggressive biological behavior of the tumor and might be indicative of poor response to chemotherapy.
DOI: 10.6084/m9.figshare.5242099
title: Erratum: Breast Cancer in Young Women - News from the BCY3 Consensus Conference

description: Medicine
DOI: 10.6084/m9.figshare.5242102
title: Erratum: Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes

description: Over the last 10 years the prevalence of obesity across the European continent has in general been rising. With the exception of a few countries where a levelling-off can be perceived, albeit at a high level, this upward trend seems likely to continue. However, considerable country to country variation is noticeable, with the proportion of people with obesity varying by 10% or more. This variation is intriguing and suggests the existence of different profiles of risk or protection factors operating in different countries. The identification of such protection factors could indicate suitable targets for interventions to help manage the obesity epidemic in Europe. This report is the output of a 2-day workshop on the ‘Diversity of Obesity in Europe'. The workshop included 14 delegates from 12 different European countries. This report contains the contributions and discussions of the materials and viewpoints provided by these 14 experts; it is not the output of a single mind. However, such is the nature of scientific analysis regarding obesity that it is possible that a different set of 14 experts may have come to a different set of conclusions. Therefore the report should not be seen as a definitive statement of a stable situation. Rather it is a focus for discussion and comment, and a vehicle to drive forward further understanding and management of obesity in Europe.
DOI: 10.6084/m9.figshare.5242090
title: Erratum: Collateral Flow and White Matter Disease in Patients with Internal Carotid Artery Occlusion

description: <b><i>Background:</i></b> When an internal carotid artery (ICA) occludes, a patient may develop cerebral infarction (CI). We investigated whether CI caused by ICA occlusion (ICAO) is associated with collateral flow through the anterior and posterior communicating arteries (ACoA and PCoA). <b><i>Methods:</i></b> In 100 patients with ICAO, we investigated CI and white matter disease by performing an MRI and the anatomy of the ACoA and PCoA were investigated by performing magnetic resonance angiography. All patients were divided into the symptomatic CI group or the no-CI group. The collateral flow pathway was estimated by the anterior cerebral artery (ACA)-PCoA score and the collateral flow volume after ICAO was estimated by the middle cerebral artery (MCA) flow score, based on how well the MCA was visualized. <b><i>Results:</i></b> Of 100 patients with ICAO, the symptomatic CI group included 36 patients. ACA-PCoA score and white matter disease grades were significantly higher in the CI group (indicating poor collateral flow). More than 80% of patients with an ACA-PCoA score of 4 (poor collateral) experienced symptomatic CI. Thirty-one symptomatic CI patients (86%) had an MCA flow score of 1 or 2 (decreased MCA flow). <b><i>Conclusion:</i></b> The ACA-PCoA score and white matter disease grade may suggest an increased risk of CI following ICAO.
DOI: 10.6084/m9.figshare.5242093
title: Erratum: HER2-Positive Neuroendocrine Breast Cancer: Case Report and Review of Literature

description: <b><i>Background:</i></b> Neuroendocrine carcinoma is an uncommon histology for breast cancer. <b><i>Case Report:</i></b> Our patient underwent right quadrantectomy for a neuroendocrine carcinoma in 1984 and had a bone relapse 30 years later. After thorough pathological and immunohistochemical analysis the diagnosis was confirmed and HER2 amplification was observed. Here we discuss the management, rationale and results of HER2-targeted therapy in advanced neuroendocrine breast carcinoma.
DOI: 10.6084/m9.figshare.5242099.v1
title: Erratum: Breast Cancer in Young Women - News from the BCY3 Consensus Conference

description: Medicine
DOI: 10.6084/m9.figshare.5242102.v1
title: Erratum: Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes

description: Over the last 10 years the prevalence of obesity across the European continent has in general been rising. With the exception of a few countries where a levelling-off can be perceived, albeit at a high level, this upward trend seems likely to continue. However, considerable country to country variation is noticeable, with the proportion of people with obesity varying by 10% or more. This variation is intriguing and suggests the existence of different profiles of risk or protection factors operating in different countries. The identification of such protection factors could indicate suitable targets for interventions to help manage the obesity epidemic in Europe. This report is the output of a 2-day workshop on the ‘Diversity of Obesity in Europe'. The workshop included 14 delegates from 12 different European countries. This report contains the contributions and discussions of the materials and viewpoints provided by these 14 experts; it is not the output of a single mind. However, such is the nature of scientific analysis regarding obesity that it is possible that a different set of 14 experts may have come to a different set of conclusions. Therefore the report should not be seen as a definitive statement of a stable situation. Rather it is a focus for discussion and comment, and a vehicle to drive forward further understanding and management of obesity in Europe.
DOI: 10.6084/m9.figshare.5242081
title: Erratum: A Retrospective Analysis of Stereoelectroencephalography and Subdural Electroencephalography for Preoperative Evaluation of Intractable Epilepsy

description: <b><i>Background:</i></b> Different methods for intracranial electrode recording have various advantages and disadvantages, and controversy exists regarding the complications of stereoelectroencephalography (SEEG) and subdural EEG. <b><i>Objective:</i></b> The purpose of this study was to determine the efficacy and safety of SEEG by comparing it with subdural EEG. <b><i>Methods:</i></b> Data from 100 patients who underwent SEEG (<i>n</i> = 48) and subdural EEG (<i>n</i> = 52) to evaluate the epileptogenic zone were collected from June 2011 to June 2015. The evaluation results, surgical outcomes, and complications were compared. <b><i>Results:</i></b> No significant differences were noted between the SEEG and subdural EEG groups in identifying the epileptogenic zone or undergoing epileptic surgery. Of the 88 patients who underwent epilepsy surgery after assessment, 59.5% in the SEEG group and 52.2% in the subdural EEG group became seizure free. No significant differences in postoperative seizure control or intelligence improvement were noted. The overall complication rate in SEEG patients (8/48; 16.7%) was lower than that in subdural EEG patients (13/52; 25%), particularly for hemorrhage and infection (4.2 vs. 17.3%, <i>p</i> &lt; 0.05). <b><i>Conclusions:</i></b> This retrospective review indicates that SEEG has low associated complications, particularly regarding hemorrhage and infection. SEEG is a safe and effective method for intracranial monitoring.
DOI: 10.6084/m9.figshare.5242087
title: Erratum: Comparison of Alternative Coupling Methods of the Vibrant Soundbridge Floating Mass Transducer

description: The active middle ear implant Vibrant Soundbridge© provides a variety of coupling modalities of the floating mass transducer (FMT) to various structures of the ossicular chain and the round window. A retrospective analysis was performed on 125 subjects (<i>n</i> = 137 ears) (1) to compare the efficacy of the different FMT coupling modalities with increasing degree of hearing loss, (2) to compare the performance in speech outcome and the effective gain between the coupling types, and (3) to evaluate the risk of additional hearing loss of each coupling procedure. The patients were grouped according to their type of FMT coupling into incus vibroplasty (incus group, <i>n</i> = 59), round window vibroplasty with coupler (RWC group, <i>n</i> = 23), round window vibroplasty without coupler (RW group, <i>n</i> = 22), and oval window vibroplasty with coupler (OWC group, <i>n</i> = 33). For each coupling group, pre- and postoperative thresholds, the results of the Freiburg monosyllable test at 65 dB SPL, and the effective gain across frequencies (0.5-6 kHz) were evaluated. A logistic regression function was used to describe the relationship between word recognition scores (WRS, in % correct) and the mean bone conduction (BC) hearing loss. The surgical procedure had no clinically relevant effect on BC thresholds of patients in each coupling group. The BC pure tone average (PTA<sub>4</sub>) for 50% WRS predicted by the model function was similar for the incus (48.2 dB nHL), RW (47.8 dB nHL), and OWC (49.0 dB nHL) groups, but higher for the RWC group (67.9 dB nHL). However, the median WRS was 80% or better with no significant differences in speech perception between coupling types (Kruskal-Wallis test, <i>p</i> = 0.229). The effective gain shows an advantage for the incus coupling between 0.5 and 2 kHz over the other coupling types. The performance of the FMT coupling modalities is equally good for patients with a mild-to-moderate hearing loss, but the efficacy of coupling types differs for patients with greater hearing loss (&gt;48 dB BC HL).
DOI: 10.6084/m9.figshare.5242093.v1
title: Erratum: HER2-Positive Neuroendocrine Breast Cancer: Case Report and Review of Literature

description: <b><i>Background:</i></b> Neuroendocrine carcinoma is an uncommon histology for breast cancer. <b><i>Case Report:</i></b> Our patient underwent right quadrantectomy for a neuroendocrine carcinoma in 1984 and had a bone relapse 30 years later. After thorough pathological and immunohistochemical analysis the diagnosis was confirmed and HER2 amplification was observed. Here we discuss the management, rationale and results of HER2-targeted therapy in advanced neuroendocrine breast carcinoma.