cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/mny13s/upg0mx
title: BIOR0003_S15B.tab

description: :unav
DOI: 10.18739/a23b5w79p
title: Alexandra Fiord Mesic Tundra Ecosystem [Welker, J., J. Fahnestock]

description: The data set presented here represents growing season (late-1999, 2000 and 2001) values of net carbon dioxide exchange, photosynthesis, and respiration between the atmosphere and mesic tundra. The site is located at Alexandra Fiord on the east-central side of Ellesmere Island, Nunavut, Canada at 78.54N 75.55W, 50 m elevation asl. As part of the International Tundra Experiment (ITEX), Greg Henry of the University of British Columbia has been increasing air and soil temperatures at this site since 1993 using small open-topped chambers (OTCs). These OTCs are hexagonal in shape and are constructed of transparent fiberglass. They typically raise air and soil temperatures by 1 to 4C. The data set shows periodic carbon dioxide exchange data from the end of the 1999 growing season and throughout the 2000 and 2001 growing seasons in ambient plots and long-term (7-9 yrs) warmed (OTC) plots. The most complete data set (2001) begins in spring before winter snowmelt and ends at the end of summer when snow has once again covered the ground. The data are from 199908040800 to 200108062400 UTC.
DOI: 10.18739/a2736m23f
title: Benthic macroinfaunal samples collected from the Canadian Coast Guard Ship (CCGS) Sir Wilfrid Laurier, Northern Bering Sea to Chukchi Sea, 2012

description: The Pacific sector of the Arctic Ocean is experiencing major reductions in seasonal sea ice extent and increases in sea surface temperatures. One of the key uncertainties in this region is how the marine ecosystem will respond to seasonal shifts in the timing of spring sea ice retreat and/or delays in fall sea ice formation. Variations in upper ocean water hydrography, planktonic production, pelagic-benthic coupling and sediment carbon cycling are all influenced by sea ice and temperature change. To more systematically track the broad biological response to sea ice retreat and associated environmental change, an international consortium of scientists have developed a coordinated “Distributed Biological Observatory” (DBO) that includes selected biological measurements at multiple trophic levels, along with satellite and mooring measurements. The DBO currently focuses on five regional biological “hotspot” locations along a latitudinal gradient that allows for consistent sampling and monitoring at five biologically productive locations across a latitudinal gradient: DBO 1 (SLIP)-south of St. Lawrence Island (SLI), DBO2 (Chirikov)-north of SLI, DBO3 (southern Chukchi Sea), DBO4-NE Chukchi Sea,and DBO5-Barrow Canyon. This dataset contains benthic macroinfaunal population level from sediment samples collected at each station for the CCGS Sir Wilfrid Laurier cruise-Leg 1 in 2012, identified by station number (#), Station name (Stn. Name), Date (mm/dd/yy), latitude (°N), longitude (°W), and station depth (m). The following macroinfaunal parameters were determined: abundance, wet weight biomass (gww/m2), dry weight biomass (gC/m2), and taxon type.
DOI: 10.18739/a2bv79v7v
title: WRF-downscaling of CMIP5/CCSM4 simulations for Jarvis Creek, Alaska, 1970-2100

description: In order to assess future climate changes and impacts on Jarvis Creek's hydrological processes in Alaska, the CMIP5-CCSM4 hindcast simulations (1970-2005) and future projections (2006-2100) under the RCP6 mitigation scenario have been downscaled with the atmospheric regional model WRF (Weather Forecasting and Research). The downscaled results of 2-m temperature, relative humidity, 10-m wind speed, download shortwave radiation and precipitation were evaluated with the in-situ observations for the study area, which provides a measure to correct systemic bias in the WRF downscaling. This dataset includes the bias-corrected downscaling of 2-m temperature, relative humidity, 10-m wind speed, download shortwave radiation and precipitation for the Jarvis Creek, AK, and covers a period of 1970-2100. The data resolution is 20 km and hourly interval.
DOI: 10.18739/a2zp3w08h
title: Surface sediment samples collected from the CCGS Sir Wilfrid Laurier, Northern Bering Sea to Chukchi Sea, 2017

description: The Pacific sector of the Arctic Ocean is experiencing major reductions in seasonal sea ice extent and increases in sea surface temperatures. One of the key uncertainties in this region is how the marine ecosystem will respond to seasonal shifts in the timing of spring sea ice retreat and/or delays in fall sea ice formation. Variations in upper ocean water hydrography, planktonic production, pelagic-benthic coupling and sediment carbon cycling are all influenced by sea ice and temperature change. To more systematically track the broad biological response to sea ice retreat and associated environmental change, an international consortium of scientists have developed a coordinated Distributed Biological Observatory(DBO) that includes selected biological measurements at multiple trophic levels, along with satellite and mooring measurements. The DBO currently focuses on five regional biological "hotspot" locations along a latitudinal gradient that allows for consistent sampling and monitoring at five biologically productive locations across a latitudinal gradient: DBO 1 (SLIP)-south of St. Lawrence Island (SLI), DBO2 (Chirikov)-north of SLI, DBO3 (southern Chukchi Sea), DBO4-NE Chukchi Sea,and DBO5-Barrow Canyon. This dataset contains summary measurements of surface sediment collected at each station for the identified cruise, including: sediment grain size (≤0 phi, 1 phi, 2 phi, 3 phi, 4 phi, &gt;=5 phi, 1-4 phi, and modal phi size), total organic carbon (TOC), total organic nitrogen (TON), C/N and surface sediment chlorophyll (chl a). Surface sediment chlorophyll (chl a) content is scaled up to mg Chl a/m2.
DOI: 10.25625/jlhl13
title: The “long-tail of science“ perspective on RDM

description: The presentation is the result of DFG financed work, AZ NI 1250/1-2 Based on so called roadshow visits of 15 working groups across Germany and a online survey, both conducted in 2017, needs, gaps and challenges for research data management with respect to biological environmental research had been presented at the general assembly of the DFG financed GFBio project, gfbio.org.
DOI: 10.5519/qd.7kqbfx6j
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (4440114 records)
DOI: 10.25625/jlhl13/4yvc4f
title: Long-tail-of-science-perspectives-on-RDM_V20190917..pptx

description: :unav
DOI: 10.6073/pasta/ac3a766a0bf95e2215ba668231f18418
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Baron Ranch (BaronRanch262)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Baron Ranch in the Santa Barbara coastal area (site ID: BaronRanch262). Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/18e5e2e9f6c77a430e1b853ee1eba1bf
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Carpinteria Fire Station (Carpinteria208)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Carpinteria Fire Station in the Santa Barbara coastal area (site ID: Carpinteria208). Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/8e12efbc31d84dbed0c105f8c8a2486f
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Cater Water Treatment Plant (CaterWTP229)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Cater Water Treatment Plant (CaterWTP229) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.7910/dvn/c28qij/ca59fr
title: BTV_plus.WP1

description: :unav
DOI: 10.7910/dvn/c28qij/n3512p
title: Winapex.SIT

description: :unav
DOI: 10.7910/dvn/c28qij/4ni9qn
title: RFDTLST.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/7tlnln
title: WIL2_NP8.SAO

description: :unav
DOI: 10.7910/dvn/c28qij/axdlbs
title: APEXRUN.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/bbhuj8
title: APEXDIM.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/jfjwjn
title: MLRN2110.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/mx4vxh
title: NewWaterS.OUT

description: :unav
DOI: 10.7910/dvn/c28qij/tp1qye
title: APGSRUN.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/waa93n
title: WIL2_NP8.ASA

description: :unav
DOI: 10.7910/dvn/c28qij/yog4jj
title: WIL2_NP8.ACY

description: :unav
DOI: 10.7910/dvn/c28qij/gofxz7
title: till.dat

description: :unav
DOI: 10.7910/dvn/c28qij/ityfkg
title: MLRN.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/jvffgt
title: RAINDT.HLY

description: :unav
DOI: 10.7910/dvn/c28qij/oalkot
title: PSOCOM.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/qzsn0u
title: WIL2_NP8.OUT

description: :unav
DOI: 10.7910/dvn/c28qij/vpdwvu
title: BTV_warme.WP1

description: :unav
DOI: 10.7910/dvn/c28qij/wj2has
title: 22.OPS

description: :unav
DOI: 10.7910/dvn/c28qij/wqumvx
title: NewWaterS.SUB

description: :unav
DOI: 10.7910/dvn/c28qij/zbkhuy
title: fort.102

description: :unav
DOI: 10.7910/dvn/c28qij/4ecaoi
title: SUBA.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/5seqon
title: BTV_80_09.WP1

description: :unav
DOI: 10.7910/dvn/c28qij/amknmi
title: RFDTCOM.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/b3noji
title: WIL2_NP8.MSA

description: :unav
DOI: 10.7910/dvn/c28qij/hyzzmt
title: WIL2_NP8.DCN

description: :unav
DOI: 10.7910/dvn/c28qij/kgrptq
title: 650.sol

description: :unav
DOI: 10.7910/dvn/c28qij/oghoti
title: WIL2_NP8.DHY

description: :unav
DOI: 10.7910/dvn/c28qij/up16zr
title: fort.108

description: :unav
DOI: 10.7910/dvn/c28qij/uss5me
title: NewWaterS.SAF

description: :unav
DOI: 10.7910/dvn/c28qij/16gdhx
title: parms.dat

description: :unav
DOI: 10.7910/dvn/c28qij/82ow2k
title: pest.dat

description: :unav
DOI: 10.7910/dvn/c28qij/aopyvx
title: WIL2_NP8.ACN

description: :unav
DOI: 10.7910/dvn/c28qij/ckdnhc
title: WIND.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/d7uc2u
title: WINAPEX.SUB

description: :unav
DOI: 10.7910/dvn/c28qij/hnqcez
title: WDLST.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/jtyf3f
title: HERD.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/m0meh9
title: SOIL35K.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/syhis1
title: TR55.DAT

description: :unav
DOI: 10.7910/dvn/vts1t9/mn6or3
title: GDGS2018_Data_PLOS_One.tab

description: :unav
DOI: 10.5281/zenodo.3431395
title: Dataset for Leslie, Peredo & Pyenson 2019

description: Supplemental dataset for Leslie et al. (2019) The data included in this Zenodo archive are primarily the derived 3D models (STL or PLY files) for the main osteological elements of USNM 10300: the skull, the left and right periotics, and the right tympanic bulla. One DICOM data file includes all CT data for right tympanic bulla and both periotics. The files in this archive include materials published with the original article in <em>PeerJ</em> (Leslie et al., 2019). The type specimen itself (USNM 10300) is housed in the Department of Paleobiology at the Smithsonian Institution's National Museum of Natural History in Washington, D.C. Skull: - 3D model created from 3D laser scan data. (PLY, 138.9 MB) right tympanic bulla: - 3D model created from CT scan data. (STL, 31 MB) - within DICOM data set. (578.1 MB) right periotic - 3D model created from CT scan data. (STL, 17.5 MB) - within DICOM data set. (578.1 MB) left periotic - 3D model created from CT scan data. (STL, 19.1 MB) - within DICOM data set. (578.1 MB)
DOI: 10.7910/dvn/c28qij/cl9zec
title: PRINT.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/gbicu1
title: APSUBRUN.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/lajifq
title: WIL2_NP8.AWP

description: :unav
DOI: 10.7910/dvn/c28qij/ow319y
title: crop.dat

description: :unav
DOI: 10.7910/dvn/c28qij/qqwib5
title: fert.dat

description: :unav
DOI: 10.7910/dvn/c28qij/tf17rw
title: APEXFILE.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/xwfktx
title: 00000001.SOT

description: :unav
DOI: 10.7910/dvn/c28qij/yngff9
title: OPSC.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/zz1hcy
title: BTV_wetSp.WP1

description: :unav
DOI: 10.5281/zenodo.3431879
title: Dataset related to article "Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin"

description: This record contains raw data related to article "Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin" Abstract Control of synapse number and function in the developing central nervous system is critical to the formation of neural circuits. Astrocytes play a key role in this process by releasing factors that promote the formation of excitatory synapses. Astrocyte-secreted thrombospondins (TSPs) induce the formation of structural synapses, which however remain post-synaptically silent, suggesting that completion of early synaptogenesis may require a two-step mechanism. Here, we show that the humoral innate immune molecule Pentraxin 3 (PTX3) is expressed in the developing rodent brain. PTX3 plays a key role in promoting functionally-active CNS synapses, by increasing the surface levels and synaptic clustering of AMPA glutamate receptors. This process involves tumor necrosis factor-induced protein 6 (TSG6), remodeling of the perineuronal network, and a β1-integrin/ERK pathway. Furthermore, PTX3 activity is regulated by TSP1, which directly interacts with the N-terminal region of PTX3. These data unveil a fundamental role of PTX3 in promoting the first wave of synaptogenesis, and show that interplay of TSP1 and PTX3 sets the proper balance between synaptic growth and synapse function in the developing brain.
DOI: 10.5281/zenodo.3431880
title: Dataset related to article "Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin"

description: This record contains raw data related to article "Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin" Abstract Control of synapse number and function in the developing central nervous system is critical to the formation of neural circuits. Astrocytes play a key role in this process by releasing factors that promote the formation of excitatory synapses. Astrocyte-secreted thrombospondins (TSPs) induce the formation of structural synapses, which however remain post-synaptically silent, suggesting that completion of early synaptogenesis may require a two-step mechanism. Here, we show that the humoral innate immune molecule Pentraxin 3 (PTX3) is expressed in the developing rodent brain. PTX3 plays a key role in promoting functionally-active CNS synapses, by increasing the surface levels and synaptic clustering of AMPA glutamate receptors. This process involves tumor necrosis factor-induced protein 6 (TSG6), remodeling of the perineuronal network, and a β1-integrin/ERK pathway. Furthermore, PTX3 activity is regulated by TSP1, which directly interacts with the N-terminal region of PTX3. These data unveil a fundamental role of PTX3 in promoting the first wave of synaptogenesis, and show that interplay of TSP1 and PTX3 sets the proper balance between synaptic growth and synapse function in the developing brain.
DOI: 10.7910/dvn/c28qij/5kecmc
title: SITE.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/acxtz0
title: SOIL.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/d35evg
title: WPM1.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/gnrtij
title: fort.112

description: :unav
DOI: 10.7910/dvn/c28qij/jxw3vx
title: WIL2_NP8.SUS

description: :unav
DOI: 10.7910/dvn/c28qij/nlu3q7
title: WIL2_NP8.SAD

description: :unav
DOI: 10.7910/dvn/c28qij/oceden
title: NewWaterS.DAT

description: :unav
DOI: 10.7910/dvn/c28qij/ssgg90
title: 00000002.SOT

description: :unav
DOI: 10.7910/dvn/c28qij/xqscm5
title: BTV_inten.WP1

description: :unav
DOI: 10.6073/pasta/5eff221a4af85d60a9cbcc6fc21fe8a4
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Cold Springs Basin (ColdSprings210)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Cold Springs Basin (ColdSprings210) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/7b10f747d108ae3352b5f4c4220a0fe3
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Doulton Tunnel (DoultonTunnel231)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Doulton Tunnel (DoultonTunnel231) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/d1f6a8acf369b65dc98c67f514febbdb
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Dos Pueblos Ranch (DosPueblos226)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Dos Pueblos Ranch (DosPueblos226) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.7910/dvn/c28qij/0vmbut
title: fort.128

description: :unav
DOI: 10.7910/dvn/c28qij/lhuidz
title: APEXCONT.DAT

description: :unav
DOI: 10.6073/pasta/89570dba46c5bcf1b58b05c08529923f
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Santa Barbara County Road Yard (GoletaRdYard211)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Santa Barbara County Road Yard (GoletaRdYard211) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/9ff3de1b0c28df029fb6ca066a29f4e1
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Edison Trail (EdisonTrail252)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Edison Trail (EdisonTrail252) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/c5819a9d15a98696e65f0efd8b45c14a
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at El Deseo (ElDeseo255)

description: Precipitation was collected by the Santa Barbara County Flood Control District at El Deseo (ElDeseo255) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/6c6ceaab7c189afc85abb893280492a8
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at KTYD (KTYD227)

description: Precipitation was collected by the Santa Barbara County Flood Control District at KTYD (KTYD227) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/7b6ddfc376fc341b1362e9ee3b1883e2
title: Sagehen Creek Creel Census, 1953-1961

description: Data package contains two data tables documenting surveys of angler catch in the Sagehen Creek. The Creel Census was conducted during the summer months of 1953-1961 by a range of surveyors. An additional data table containing information about trout planting in Sagehen Creek prior to the Census is also included.
DOI: 10.6073/pasta/c8059b7b1e6502e65690efc39966f261
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at Nojoqui Falls Park (Nojoqui236)

description: Precipitation was collected by the Santa Barbara County Flood Control District at Nojoqui Falls Park (Nojoqui236) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.6073/pasta/eb0709b8d0b171f0928a65b3cffeadbe
title: SBC LTER: Land: Hydrology: Santa Barbara County Flood Control District - Precipitation at San Marcos Pass USFS Stn (SanMarcosPass212)

description: Precipitation was collected by the Santa Barbara County Flood Control District at San Marcos Pass USFS Stn (SanMarcosPass212) in the Santa Barbara coastal area. Data are reported hourly, and times reflect the end of the each 1-hour interval. For more information, see https://www.countyofsb.org/pwd/hydrology.sbc
DOI: 10.5281/zenodo.3432069
title: Dataset related to article "ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity"

description: This record contains raw data related to article "ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity" Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here we report that ACKR2 is expressed in hematopoietic precursors and downregulated during myeloid differentiation. Genetic inactivation of ACKR2 results in increased levels of inflammatory chemokine receptors and release from the bone marrow of neutrophils with increased anti-metastatic activity. In a model of NeuT-driven primary mammary carcinogenesis ACKR2 deficiency is associated with increased primary tumor growth and protection against metastasis. ACKR2 deficiency results in neutrophil-mediated protection against metastasis in mice orthotopically transplanted with 4T1 mammary carcinoma and intravenously injected with B16F10 melanoma cell lines. Thus, ACKR2 is a key regulator (checkpoint) of mouse myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils in mice.
DOI: 10.5281/zenodo.3432070
title: Dataset related to article "ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity"

description: This record contains raw data related to article "ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity" Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here we report that ACKR2 is expressed in hematopoietic precursors and downregulated during myeloid differentiation. Genetic inactivation of ACKR2 results in increased levels of inflammatory chemokine receptors and release from the bone marrow of neutrophils with increased anti-metastatic activity. In a model of NeuT-driven primary mammary carcinogenesis ACKR2 deficiency is associated with increased primary tumor growth and protection against metastasis. ACKR2 deficiency results in neutrophil-mediated protection against metastasis in mice orthotopically transplanted with 4T1 mammary carcinoma and intravenously injected with B16F10 melanoma cell lines. Thus, ACKR2 is a key regulator (checkpoint) of mouse myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils in mice.