cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21353187.v1
title: Vestibular rehabilitation therapy in combination with transcranial direct current stimulation (tDCS) for treatment of chronic vestibular dysfunction in the elderly: a double-blind randomized controlled trial

description: Abstract Introduction Dizziness and imbalance are common dysfunctions in the elderly. Vestibular rehabilitation therapy is an effective method to alleviate chronic dizziness in patients with vestibular dysfunction. Transcranial direct current stimulation has reportedly improved balance function in patients with vestibular dysfunction. Objective This study was conducted to investigate the therapeutic efficacy of vestibular rehabilitation combined with transcranial direct current stimulation in elderly patients with vestibular dysfunction. Methods In a double-blinded randomized controlled trial, 36 elderly patients with chronic vestibular dysfunction were randomly assigned to either vestibular rehabilitation and transcranial direct current stimulation (n = 18) or vestibular rehabilitation alone (n = 18) group. The transcranial stimulation protocol consisted of multisession bifrontal electrical stimulation of the dorsolateral prefrontal cortex (2 mA intensity and 20 min duration), followed by rehabilitation exercises. The vestibular rehabilitation protocol consisted of habituation and adaptation exercises combined with gait exercises during a three week period. The primary outcome of this study was the dizziness handicap inventory score, and the secondary outcomes were activities-specific balance confidence and Beck anxiety inventory scores. Results For the dizziness handicap score, the repeated-measures analysis of variance showed a significant main effect of “time”, “stimulation” and stimulation × time interaction effect. There was a significant reduction in the overall dizziness handicap score with “time” for both the groups, which was more pronounced in the vestibular rehabilitation and electrical stimulation group. In terms of activities-specific balance confidence change scores, we found a significant main effect of “time” and “stimulation” main factors, but this effect for stimulation × time interaction was not significant. For the Beck anxiety score, we observed a significant main effect of “time”, but no evidence for the main effect of the “stimulation” factor. Conclusion Bifrontal transcranial direct current stimulation in combination with vestibular rehabilitation therapy is a promising approach to improve chronic vestibular symptoms in the elderly.
DOI: 10.6084/m9.figshare.21353187
title: Vestibular rehabilitation therapy in combination with transcranial direct current stimulation (tDCS) for treatment of chronic vestibular dysfunction in the elderly: a double-blind randomized controlled trial

description: Abstract Introduction Dizziness and imbalance are common dysfunctions in the elderly. Vestibular rehabilitation therapy is an effective method to alleviate chronic dizziness in patients with vestibular dysfunction. Transcranial direct current stimulation has reportedly improved balance function in patients with vestibular dysfunction. Objective This study was conducted to investigate the therapeutic efficacy of vestibular rehabilitation combined with transcranial direct current stimulation in elderly patients with vestibular dysfunction. Methods In a double-blinded randomized controlled trial, 36 elderly patients with chronic vestibular dysfunction were randomly assigned to either vestibular rehabilitation and transcranial direct current stimulation (n = 18) or vestibular rehabilitation alone (n = 18) group. The transcranial stimulation protocol consisted of multisession bifrontal electrical stimulation of the dorsolateral prefrontal cortex (2 mA intensity and 20 min duration), followed by rehabilitation exercises. The vestibular rehabilitation protocol consisted of habituation and adaptation exercises combined with gait exercises during a three week period. The primary outcome of this study was the dizziness handicap inventory score, and the secondary outcomes were activities-specific balance confidence and Beck anxiety inventory scores. Results For the dizziness handicap score, the repeated-measures analysis of variance showed a significant main effect of “time”, “stimulation” and stimulation × time interaction effect. There was a significant reduction in the overall dizziness handicap score with “time” for both the groups, which was more pronounced in the vestibular rehabilitation and electrical stimulation group. In terms of activities-specific balance confidence change scores, we found a significant main effect of “time” and “stimulation” main factors, but this effect for stimulation × time interaction was not significant. For the Beck anxiety score, we observed a significant main effect of “time”, but no evidence for the main effect of the “stimulation” factor. Conclusion Bifrontal transcranial direct current stimulation in combination with vestibular rehabilitation therapy is a promising approach to improve chronic vestibular symptoms in the elderly.
DOI: 10.6084/m9.figshare.21353189
title: The influence of season, environment, sex, and body mass on biochemical profile of the freshwater turtle Phrynops geoffroanus (Schweigger, 1812)

description: ABSTRACT We analyzed the influence of the season, the environment, and the sex, as well as the relation of body mass (BM) in the serum albumin (ALB), aspartate aminotransferase (AST), creatinine (C), creatine kinase (CK), phosphorus (P), total calcium (tCa), total protein (TP), urea (U), uric acid (UA), calcium:phosphorus ratio (Ca:P), and the globulin value (GV) of thirty individuals of Phrynops geoffroanus of the urban area of Cuiabá, Mato Grosso, Brazil. The modeling of biochemical parameters was performed using the Generalized Additive Models for Location, Scale and Shape (GAMLSS) to verify the influence of variables considered in this study on each of the biochemical parameters analyzed. The season influenced AST, CK, C, tCa, Ca:P and UA. The environment influenced tCa, Ca:P, U and UA. On the other hand, CK, tCa, P, Ca:P and U differed significantly between males and females. Regarding the BM, a relationship of this variable was observed with CK, C, tCa, P, U, UA and Ca:P. We concluded that the season, environment, sex, and body mass can influence the biochemical parameters of P. geoffroanus, and these factors should be routinely considered in the interpretation of laboratory results.
DOI: 10.6084/m9.figshare.21353189.v1
title: The influence of season, environment, sex, and body mass on biochemical profile of the freshwater turtle Phrynops geoffroanus (Schweigger, 1812)

description: ABSTRACT We analyzed the influence of the season, the environment, and the sex, as well as the relation of body mass (BM) in the serum albumin (ALB), aspartate aminotransferase (AST), creatinine (C), creatine kinase (CK), phosphorus (P), total calcium (tCa), total protein (TP), urea (U), uric acid (UA), calcium:phosphorus ratio (Ca:P), and the globulin value (GV) of thirty individuals of Phrynops geoffroanus of the urban area of Cuiabá, Mato Grosso, Brazil. The modeling of biochemical parameters was performed using the Generalized Additive Models for Location, Scale and Shape (GAMLSS) to verify the influence of variables considered in this study on each of the biochemical parameters analyzed. The season influenced AST, CK, C, tCa, Ca:P and UA. The environment influenced tCa, Ca:P, U and UA. On the other hand, CK, tCa, P, Ca:P and U differed significantly between males and females. Regarding the BM, a relationship of this variable was observed with CK, C, tCa, P, U, UA and Ca:P. We concluded that the season, environment, sex, and body mass can influence the biochemical parameters of P. geoffroanus, and these factors should be routinely considered in the interpretation of laboratory results.
DOI: 10.6084/m9.figshare.21353205
title: Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review

description: Abstract Introduction SARS-CoV-2 is the pathogen of COVID-19. The virus is composed of the spike, membrane and envelope. On physiological smell, odoriferous substances bind to proteins secreted by sustentacular cells in order to be processed by olfactory receptor neurons. Olfactory disorder is one of the main manifestations of COVID-19, however, research is still required to clarify the mechanism involved in SARS-CoV-2 induced anosmia. Objective This article aims to analyze current scientific evidence intended to elucidate the pathophysiological relationship between COVID-19 and the cause of olfactory disorders. Methods Pubmed, Embase, Scopus and ScienceDirect were used to compose this article. The research was conducted on November 24th, 2020. Original articles with experimental studies in human, animal and in vitro, short communications, viewpoint, published in the English language and between 2019 and 2020 were included, all related to the pathophysiological relationship between olfactory disorders and COVID-19 infection. Results Both human cell receptors ACE2 and TMPRSS2 are essential for the SARS-CoV-2 entrance. These receptors are mostly present in the olfactory epithelium cells, therefore, the main hypothesis is that anosmia is caused due to damage to non-neuronal cells which, thereafter, affects the normal olfactory metabolism. Furthermore, magnetic resonance imaging studies exhibit a relationship between a reduction on the neuronal epithelium and the olfactory bulb atrophy. Damage to non-neuronal cells explains the average recovery lasting a few weeks. This injury can be exacerbated by an aggressive immune response, which leads to damage to neuronal cells and stem cells inducing a persistent anosmia. Conductive anosmia is not sufficient to explain most cases of COVID-19 induced anosmia. Conclusion Olfactory disorders such as anosmia and hyposmia can be caused by COVID-19, the main mechanism is associated with olfactory epithelium damage, targeting predominantly non-neuronal cells. However, neuronal cells can also be affected, worsening the condition of olfactory loss.
DOI: 10.6084/m9.figshare.21353205.v1
title: Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review

description: Abstract Introduction SARS-CoV-2 is the pathogen of COVID-19. The virus is composed of the spike, membrane and envelope. On physiological smell, odoriferous substances bind to proteins secreted by sustentacular cells in order to be processed by olfactory receptor neurons. Olfactory disorder is one of the main manifestations of COVID-19, however, research is still required to clarify the mechanism involved in SARS-CoV-2 induced anosmia. Objective This article aims to analyze current scientific evidence intended to elucidate the pathophysiological relationship between COVID-19 and the cause of olfactory disorders. Methods Pubmed, Embase, Scopus and ScienceDirect were used to compose this article. The research was conducted on November 24th, 2020. Original articles with experimental studies in human, animal and in vitro, short communications, viewpoint, published in the English language and between 2019 and 2020 were included, all related to the pathophysiological relationship between olfactory disorders and COVID-19 infection. Results Both human cell receptors ACE2 and TMPRSS2 are essential for the SARS-CoV-2 entrance. These receptors are mostly present in the olfactory epithelium cells, therefore, the main hypothesis is that anosmia is caused due to damage to non-neuronal cells which, thereafter, affects the normal olfactory metabolism. Furthermore, magnetic resonance imaging studies exhibit a relationship between a reduction on the neuronal epithelium and the olfactory bulb atrophy. Damage to non-neuronal cells explains the average recovery lasting a few weeks. This injury can be exacerbated by an aggressive immune response, which leads to damage to neuronal cells and stem cells inducing a persistent anosmia. Conductive anosmia is not sufficient to explain most cases of COVID-19 induced anosmia. Conclusion Olfactory disorders such as anosmia and hyposmia can be caused by COVID-19, the main mechanism is associated with olfactory epithelium damage, targeting predominantly non-neuronal cells. However, neuronal cells can also be affected, worsening the condition of olfactory loss.
DOI: 10.6084/m9.figshare.21353208
title: Biomechanical comparison of a modified TPLO plate, a locking compression plate, and plate-rod constructs applied medially in a proximal gap model in canine synthetic tibias

description: ABSTRACT The aim of this study was to develop a modified tibial plateau leveling osteotomy (TPLO) plate and to compare its biomechanical properties with a locking compression plate (LCP) and plate-rod constructs for the stabilization of experimentally induced gap fractures in canine synthetic tibias. The tibial models were assigned to either repair with a modified TPLO plate (Group 1), locking compression plate construct (Group 2), or plate-rod construct (Group 3). The specimens were loaded to failure in axial compression, three-point mediolateral and craniocaudal bending. There was no statistical difference between the three groups regarding stiffness (N/mm) and deformation (mm) in axial compression. The modified TPLO plate achieved load to failure similar to the plate-rod construct in craniocaudal bending. There was no significant difference between groups on mediolateral bending tests regarding load to failure and deformation. Furthermore, there was no significant difference in stiffness between groups 1 and 2. In conclusion, the modified TPLO plate had similar mechanical properties to LCP and plate-rod construct in the axial compression and bending tests. Nonetheless, clinical studies with a large population of dogs are required to determine the value of this new implant in proximal tibial fracture repair.
DOI: 10.6084/m9.figshare.21353208.v1
title: Biomechanical comparison of a modified TPLO plate, a locking compression plate, and plate-rod constructs applied medially in a proximal gap model in canine synthetic tibias

description: ABSTRACT The aim of this study was to develop a modified tibial plateau leveling osteotomy (TPLO) plate and to compare its biomechanical properties with a locking compression plate (LCP) and plate-rod constructs for the stabilization of experimentally induced gap fractures in canine synthetic tibias. The tibial models were assigned to either repair with a modified TPLO plate (Group 1), locking compression plate construct (Group 2), or plate-rod construct (Group 3). The specimens were loaded to failure in axial compression, three-point mediolateral and craniocaudal bending. There was no statistical difference between the three groups regarding stiffness (N/mm) and deformation (mm) in axial compression. The modified TPLO plate achieved load to failure similar to the plate-rod construct in craniocaudal bending. There was no significant difference between groups on mediolateral bending tests regarding load to failure and deformation. Furthermore, there was no significant difference in stiffness between groups 1 and 2. In conclusion, the modified TPLO plate had similar mechanical properties to LCP and plate-rod construct in the axial compression and bending tests. Nonetheless, clinical studies with a large population of dogs are required to determine the value of this new implant in proximal tibial fracture repair.
DOI: 10.6084/m9.figshare.21353210
title: Cognitive Memory Training with Healthy Elderly: Meta-Analysis and Comparison of Strategies

description: Abstract Memory training is an alternative for cognitive improvement with elderly, currently evidenced in Brazilian research. Nevertheless, there is no verification of the differences between types of training, in order to identify the effectiveness of different strategies in intervention. Therefore, this paper seeks to compare strategies adopted in the Brazilian context. A meta-analysis was carried out, evaluating the effect size, publication bias and heterogeneity of the studies. The results indicate a statistically insignificant effect from insignificant to moderate on the worked memory subsystems, although with a moderate and significant effect on incidental memory. The presence of bias in publications and high heterogeneity between studies are indicated. Subsequent meta-analyses should associate the results with methodological characteristics of the works.
DOI: 10.6084/m9.figshare.21353210.v1
title: Cognitive Memory Training with Healthy Elderly: Meta-Analysis and Comparison of Strategies

description: Abstract Memory training is an alternative for cognitive improvement with elderly, currently evidenced in Brazilian research. Nevertheless, there is no verification of the differences between types of training, in order to identify the effectiveness of different strategies in intervention. Therefore, this paper seeks to compare strategies adopted in the Brazilian context. A meta-analysis was carried out, evaluating the effect size, publication bias and heterogeneity of the studies. The results indicate a statistically insignificant effect from insignificant to moderate on the worked memory subsystems, although with a moderate and significant effect on incidental memory. The presence of bias in publications and high heterogeneity between studies are indicated. Subsequent meta-analyses should associate the results with methodological characteristics of the works.
DOI: 10.6084/m9.figshare.21340623
title: International development cooperation as a global governance policy

description: Abstract The three major international texts adopted in 2015 -Addis Ababa Action Agenda on financing for development, 2030 Agenda for Sustainable Development and Paris Climate Agreement- place national public policies and actors at the heart of international development cooperation (IDC). By bringing IDC closer to national institutions, particularly development banks, and taking it further away from traditional foreign policy, this shift has challenged long-held IDC narratives and structures, both among developed and developing countries. It has also laid the foundations for a degree of structured and universal accountability within the international development cooperation system, setting the stage for a wider shift within global governance.
DOI: 10.6084/m9.figshare.21340623.v1
title: International development cooperation as a global governance policy

description: Abstract The three major international texts adopted in 2015 -Addis Ababa Action Agenda on financing for development, 2030 Agenda for Sustainable Development and Paris Climate Agreement- place national public policies and actors at the heart of international development cooperation (IDC). By bringing IDC closer to national institutions, particularly development banks, and taking it further away from traditional foreign policy, this shift has challenged long-held IDC narratives and structures, both among developed and developing countries. It has also laid the foundations for a degree of structured and universal accountability within the international development cooperation system, setting the stage for a wider shift within global governance.
DOI: 10.6084/m9.figshare.21353219
title: Calibration of chlorophyll hand-held meter based on vineyard NDVI zones for estimation of leaf N content

description: ABSTRACT The monitoring of chlorophyll content in grapevine leaves allows us to evaluate their N status, assisting with the information for the decision make about nutrient rate and application time to the vineyard. The present work aimed to propose an easy-to-use procedure for the calibration of a chlorophyll hand-held meter based on the NDVI homogeneous zones in a vineyard for the device readings and leaf sampling. We evaluated the wine grape ‘Chardonnay’ growing under drip irrigation in a vineyard located in the Southeast region of Brazil. Readings of the relative chlorophyll indices (a, b, and total) were taken in situ four times throughout the 2019 growing season, with the device placed on two leaves of every 40 pre-selected target plants in two homogeneous zones of NDVI previously defined in the vineyard. Subsequently, the chlorophyll and leaf nitrogen contents were determined in laboratory to relate them to the chlorophyll meter readings through generalized estimation equations. The chlorophyll meter is capable of estimating the levels of chlorophyll a, b and total by the models generated with an error of 0.98, 0.58, and 1.47 µg ml-1 cm-2 for calibration and of 1.03, 0.67, and 1.49 µg ml -1 cm-2 for prediction, respectively. The functions developed for the leaf N content present calibration error of 1.49 g kg-1 and prediction error of 3.39 g kg-1, but capable of providing an estimate when error is less than the amplitude of nitrogen sufficiency.
DOI: 10.6084/m9.figshare.21353219.v1
title: Calibration of chlorophyll hand-held meter based on vineyard NDVI zones for estimation of leaf N content

description: ABSTRACT The monitoring of chlorophyll content in grapevine leaves allows us to evaluate their N status, assisting with the information for the decision make about nutrient rate and application time to the vineyard. The present work aimed to propose an easy-to-use procedure for the calibration of a chlorophyll hand-held meter based on the NDVI homogeneous zones in a vineyard for the device readings and leaf sampling. We evaluated the wine grape ‘Chardonnay’ growing under drip irrigation in a vineyard located in the Southeast region of Brazil. Readings of the relative chlorophyll indices (a, b, and total) were taken in situ four times throughout the 2019 growing season, with the device placed on two leaves of every 40 pre-selected target plants in two homogeneous zones of NDVI previously defined in the vineyard. Subsequently, the chlorophyll and leaf nitrogen contents were determined in laboratory to relate them to the chlorophyll meter readings through generalized estimation equations. The chlorophyll meter is capable of estimating the levels of chlorophyll a, b and total by the models generated with an error of 0.98, 0.58, and 1.47 µg ml-1 cm-2 for calibration and of 1.03, 0.67, and 1.49 µg ml -1 cm-2 for prediction, respectively. The functions developed for the leaf N content present calibration error of 1.49 g kg-1 and prediction error of 3.39 g kg-1, but capable of providing an estimate when error is less than the amplitude of nitrogen sufficiency.
DOI: 10.6084/m9.figshare.21353220
title: Virtual simulations for health education: how are user skills assessed?

description: Abstract: Introduction: A virtual simulator, or one based on virtual reality, can computationally recreate real contexts. Objective: To analyze works on virtual simulations for training clinical procedures, focusing on the assessment of user skills. Method: Integrative literature review, carried out between 2010 and 2020. A total of 56 studies were selected 56 studies. Results: The selected studies showed that the variables and parameters of virtual simulators are usually obtained by consulting experts or through medical literature. These simulators mainly focus on developing psychomotor skills and assessing the learner’s performance through real-time alerts, progress indicators, and performance reports after the end of each training. Conclusion: Considering the expert’s knowledge exclusively to define the requirements of virtual simulators can limit their reliability and accuracy. The participation of experts in these projects does not follow standards regarding the selection and frequency with which they collaborate. Few simulators provide insightful and pertinent feedback on user performance.