cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22132977.v1
title: Development of a co-created online self-management program for people with lower limb loss: self-management for amputee rehabilitation using technology (SMART)

description: To develop an online self-management program for individuals with recent lower limb loss, called Self-Management for Amputee Rehabilitation using Technology (SMART). We used the Intervention Mapping Framework as a blueprint and involved stakeholders throughout the process. A six-step study was conducted including (1) needs assessment using interviews, (2) translating needs to content, (3) applying the content into a prototype using theory-based methods, (4) a usability assessment using think-aloud cognitive testing, (5) planning for future adoption and implementation, and (6) assessing feasibility using mixed-methods to generate a plan to assess the effectiveness on health-outcomes in a randomized controlled trial. Following interviews with healthcare professionals (<i>n</i> = 31) and people with lower limb loss (<i>n</i> = 26), we determined the content of a prototype version. We then tested usability (<i>n</i> = 9) and feasibility (<i>n</i> = 12) by recruiting individuals with lower limb loss from different pools. We modified SMART to be assessed in a randomized controlled trial. SMART is a six-week online program with weekly contact of a peer mentor with lower limb loss who supported patients with goal-setting and action-planning. Intervention mapping facilitated the systematic development of SMART. SMART may improve health outcomes, but this would need to be confirmed in future studies.Implications for rehabilitationLearning new coping strategies and habits are essential after lower limb loss.Given the limitations and inaccessibility of educational and rehabilitation programs, online self-management education can assist patients in their recovery.Self-Management for Amputee Rehabilitation using Technology (SMART) has the potential to augment the self-management behaviors in individuals with lower limb loss through an improvement in access to educational content, skill-based videos, and support of a peer. Learning new coping strategies and habits are essential after lower limb loss. Given the limitations and inaccessibility of educational and rehabilitation programs, online self-management education can assist patients in their recovery. Self-Management for Amputee Rehabilitation using Technology (SMART) has the potential to augment the self-management behaviors in individuals with lower limb loss through an improvement in access to educational content, skill-based videos, and support of a peer.
DOI: 10.6084/m9.figshare.20115807
title: Additional file 1 of Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes

description: Additional file 1.
DOI: 10.6084/m9.figshare.21967445.v1
title: An umbrella review of the literature on the effectiveness of goal setting interventions in improving health outcomes in chronic conditions

description: To identify the contexts in which goal setting has been used in chronic disease management interventions and to estimate the magnitude of its effect on improvement of health outcomes. The strength of evidence and extent of potential bias in the published systematic reviews of goal setting interventions in chronic conditions were summarized using AMSTAR2 quality appraisal tool, number of participants, 95% prediction intervals, and between-study heterogeneity. Components of goal setting interventions were also extracted. Nine publications and 35 meta-analysis models were identified, investigating 25 health outcomes. Of the 35 meta-analyses, none found strong evidence and three provided some suggestive evidence on symptom reduction and perceived well-being. There was weak evidence for effects on eight health outcomes (HbA1c, self-efficacy, depression, anxiety, distress, medication adherence, health-related quality of life and physical activity), with the rest classified as non-significant. Half of the meta-analyses had high level of heterogeneity. Goal setting by itself affects outcomes of chronic diseases only to a small degree. This is not unexpected finding as changing outcomes in chronic diseases requires a complex and individualized approach. Implementing goal setting in a standardized way in the management of chronic conditions would seem to be a way forward.IMPLICATIONS FOR REHABILITATIONThe link between goal setting and health outcomes seems to be weak.Some levels of positive behavioural change could be of benefits to patients as seen by improved self-efficacy, patients’ satisfaction and overall quality of life.Systematic and consistent application of personalized goal-oriented interventions considering patient’s readiness to change could better predict improved outcomes.Incorporation of various goal setting components while actively engaging patient and/or their care givers in the process could appraise how goal setting could help with challenges in faced by people living with chronic conditions in different areas. The link between goal setting and health outcomes seems to be weak. Some levels of positive behavioural change could be of benefits to patients as seen by improved self-efficacy, patients’ satisfaction and overall quality of life. Systematic and consistent application of personalized goal-oriented interventions considering patient’s readiness to change could better predict improved outcomes. Incorporation of various goal setting components while actively engaging patient and/or their care givers in the process could appraise how goal setting could help with challenges in faced by people living with chronic conditions in different areas.
DOI: 10.6084/m9.figshare.12775258.v1
title: Additional file 2 of The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

description: Additional file 2. Supplementary Information-2.
DOI: 10.6084/m9.figshare.11742822
title: Co-Expression Network Analysis Identified Genes Associated with Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma

description: <b>Objective:</b> Cancer stem cells are self-renewal cells in tumors and can produce heterogeneous tumor cells, which play an important role in the development of lung squamous cell carcinoma (LSCC). In our research, we aimed to explore the expression of genes related to LSCC stem cells. <b>Methods:</b> We downloaded the RNAseq data, the pathological and prognostic profiles of LSCC cases from the public database TCGA. The mRNA expression-based stiffness index (mRNAsi) of LSCC was calculated and the prognostic value of mRNAsi was discussed. Then, we constructed a weighted gene co-expression network analysis (WGCNA) to screen key genes related to mRNAsi of LSCC. <b>Results:</b> MRNAsi is an independent prognostic factor in LSCC. We screened 5 key genes (BUB1, BIRC5, CCNB2, KIF15 and SPAG5) related to mRNAsi of LSCC based on WGCNA. The key genes were highly expressed in the tumor samples compared to the normal samples. In addition, there is a strong interaction between proteins of these key genes and a strong co-expression relationship at the transcriptional level. <b>Conclusions:</b> To conclude, mRNAsi play an important role in LSCC. Five key genes (BUB1, BIRC5, CCNB2, KIF15 and SPAG5) related to mRNAsi were screened, which may act as therapeutic targets for inhibiting the stem cell characteristics of LSCC.
DOI: 10.6084/m9.figshare.11742822.v1
title: Co-Expression Network Analysis Identified Genes Associated with Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma

description: <b>Objective:</b> Cancer stem cells are self-renewal cells in tumors and can produce heterogeneous tumor cells, which play an important role in the development of lung squamous cell carcinoma (LSCC). In our research, we aimed to explore the expression of genes related to LSCC stem cells. <b>Methods:</b> We downloaded the RNAseq data, the pathological and prognostic profiles of LSCC cases from the public database TCGA. The mRNA expression-based stiffness index (mRNAsi) of LSCC was calculated and the prognostic value of mRNAsi was discussed. Then, we constructed a weighted gene co-expression network analysis (WGCNA) to screen key genes related to mRNAsi of LSCC. <b>Results:</b> MRNAsi is an independent prognostic factor in LSCC. We screened 5 key genes (BUB1, BIRC5, CCNB2, KIF15 and SPAG5) related to mRNAsi of LSCC based on WGCNA. The key genes were highly expressed in the tumor samples compared to the normal samples. In addition, there is a strong interaction between proteins of these key genes and a strong co-expression relationship at the transcriptional level. <b>Conclusions:</b> To conclude, mRNAsi play an important role in LSCC. Five key genes (BUB1, BIRC5, CCNB2, KIF15 and SPAG5) related to mRNAsi were screened, which may act as therapeutic targets for inhibiting the stem cell characteristics of LSCC.
DOI: 10.6084/m9.figshare.20115755.v1
title: Additional file 1 of Posterior scleral reinforcement for the treatment of myopic traction maculopathy

description: Additional file 1.
DOI: 10.6084/m9.figshare.21992064.v1
title: More than just double discrimination: a scoping review of the experiences and impact of ableism and racism in employment

description: Research has shed light on the employment barriers faced by individuals with disabilities, and by racialized people. The challenges faced by people belonging to both marginalized groups are less well-understood. The purpose of this scoping review was to examine existing research on labour market and workplace experiences of racialized people with disabilities, and to identify how ableism and racism intersect to shape employment experiences and outcomes. Seven international databases were searched, covering the period from 2000 to April 2022. Four reviewers independently conducted the screening, and data extraction and analysis were performed on 44 articles that met our inclusion criteria. The findings highlighted rates of workplace ableism and racism (including discrimination allegations and perceived discrimination); types and forms of experiences arising from the intersection of ableism and racism (including unique individual stereotyping and systemic and institutional discrimination); and the role of other demographic variables. The intersection of ableism and racism impacted labour market outcomes, well-being in the workplace, and career/professional advancement. Our review highlights the need for greater in-depth research focusing explicitly on the intersection of ableism and racism (and of other forms of discrimination), to better understand and address the barriers that racialized people with disabilities face in employment.IMPLICATIONS FOR REHABILITATIONThe experiences of racialized people with disabilities have been under explored, and clinicians and rehabilitation specialists should consider incorporating intersectionality into their practices to better understand and serve these populations.Ableism and racism do not operate in isolation, and clinicians and other professionals need to be aware that racialized people with disabilities may face unique challenges and barriers as a result.Service providers should aim to address gaps and inequities in services faced by racialized people with disabilities which may prevent them from finding and/or maintaining meaningful employment. The experiences of racialized people with disabilities have been under explored, and clinicians and rehabilitation specialists should consider incorporating intersectionality into their practices to better understand and serve these populations. Ableism and racism do not operate in isolation, and clinicians and other professionals need to be aware that racialized people with disabilities may face unique challenges and barriers as a result. Service providers should aim to address gaps and inequities in services faced by racialized people with disabilities which may prevent them from finding and/or maintaining meaningful employment.
DOI: 10.6084/m9.figshare.19593947
title: Additional file 6 of A stepwise data interpretation process for renal amyloidosis typing by LMD-MS

description: Additional file 6: Supplementary Table 4. H-score calculation of immunoglobulin related amyloidosis in validation set.
DOI: 10.6084/m9.figshare.16969114
title: Additional file 2 of The ensemble learning model is not better than the Asian modified CKD-EPI equation for glomerular filtration rate estimation in Chinese CKD patients in the external validation study

description: Additional file 2. (XLS 179 kb)
DOI: 10.6084/m9.figshare.23788292.v1
title: Additional file 1 of MFNG is an independent prognostic marker for osteosarcoma

description: Additional file 1. Table S1. The prognosis-related gene in OS.
DOI: 10.6084/m9.figshare.12775258
title: Additional file 2 of The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

description: Additional file 2. Supplementary Information-2.
DOI: 10.6084/m9.figshare.20115435.v1
title: Additional file 1 of Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis

description: Additional file 1.
DOI: 10.5281/zenodo.10654151
title: Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency

description: Original code
DOI: 10.5281/zenodo.10654152
title: Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency

description: Original code
DOI: 10.6084/m9.figshare.16969258
title: Additional file 4 of A novel adenylate isopentenyltransferase 5 regulates shoot branching via the ATTTA motif in Camellia sinensis

description: Additional file 4.
DOI: 10.6084/m9.figshare.23788346
title: Additional file 1 of The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19

description: Additional file 1: Supplementary table 1. The 1616 differentially expressed genes between periodontitis and healthy control. Supplementary table 2. The 10201 differentially expressed genes between COVID-19 and healthy control. Supplementary table 3. The 175 pairs of co-upregulated TF between periodontitis and COVID-19.
DOI: 10.6084/m9.figshare.23788301.v1
title: Additional file 4 of MFNG is an independent prognostic marker for osteosarcoma

description: Additional file 4. Table S4. GO result for differential expression genes.
DOI: 10.6084/m9.figshare.22132977
title: Development of a co-created online self-management program for people with lower limb loss: self-management for amputee rehabilitation using technology (SMART)

description: To develop an online self-management program for individuals with recent lower limb loss, called Self-Management for Amputee Rehabilitation using Technology (SMART). We used the Intervention Mapping Framework as a blueprint and involved stakeholders throughout the process. A six-step study was conducted including (1) needs assessment using interviews, (2) translating needs to content, (3) applying the content into a prototype using theory-based methods, (4) a usability assessment using think-aloud cognitive testing, (5) planning for future adoption and implementation, and (6) assessing feasibility using mixed-methods to generate a plan to assess the effectiveness on health-outcomes in a randomized controlled trial. Following interviews with healthcare professionals (<i>n</i> = 31) and people with lower limb loss (<i>n</i> = 26), we determined the content of a prototype version. We then tested usability (<i>n</i> = 9) and feasibility (<i>n</i> = 12) by recruiting individuals with lower limb loss from different pools. We modified SMART to be assessed in a randomized controlled trial. SMART is a six-week online program with weekly contact of a peer mentor with lower limb loss who supported patients with goal-setting and action-planning. Intervention mapping facilitated the systematic development of SMART. SMART may improve health outcomes, but this would need to be confirmed in future studies.Implications for rehabilitationLearning new coping strategies and habits are essential after lower limb loss.Given the limitations and inaccessibility of educational and rehabilitation programs, online self-management education can assist patients in their recovery.Self-Management for Amputee Rehabilitation using Technology (SMART) has the potential to augment the self-management behaviors in individuals with lower limb loss through an improvement in access to educational content, skill-based videos, and support of a peer. Learning new coping strategies and habits are essential after lower limb loss. Given the limitations and inaccessibility of educational and rehabilitation programs, online self-management education can assist patients in their recovery. Self-Management for Amputee Rehabilitation using Technology (SMART) has the potential to augment the self-management behaviors in individuals with lower limb loss through an improvement in access to educational content, skill-based videos, and support of a peer.
DOI: 10.5281/zenodo.6088817
title: Data for "Let's not wing it: Effective conservation of subterranean-roosting bats"

description: Database as both excel (.xls) and tab-delimited (.csv) associated with the publication: 


Meierhofer M.B., et al. (2023) Let’s not wing it: Effective conservation of subterranean-roosting bats. Conservation biology.


Please refer to the main publication for a detailed description. An explanation of the database is available in the Metadata file uploaded alongside the database. R code to reproduce the analysis pipeline is available on GitHub:


https://github.com/StefanoMammola/Analysis_Cave_bat_conservation.git
description: Additional support is provided by Biodiversa+ 2021–2022 Join call, through the project "DarCo: The vertical dimension of conservation: A cost-effective plan to incorporate subterranean ecosystems in post-2020 biodiversity and climate change agendas", by the Academy of Finland (no. 339265 and 331515), by Kone Foundation (no. 202007611), and by Brazilian CNPq (grant no. 306574/2020-9)
DOI: 10.5281/zenodo.6088818
title: Data for "Towards evidence-based conservation of subterranean ecosystems"

description: Database as both excel (.xls) and tab-delimited (.csv) associated with the publication: <strong>Mammola S., et al. (2022) Towards evidence-based conservation of subterranean ecosystems. Biological Reviews, doi: 10.1111/brv.12851</strong> Please refer to the main publication for a detailed description. Explanation of the database is available in the Database_Mammola_et_al_Metadata.pdf file uploaded alongside the database. R code to reproduce the analysis pipeline is available in GitHub: <strong>https://github.com/StefanoMammola/Analysis_Practical-Subterranean-Conservation.git</strong>
description: Additional support is provided by the PRIN SHOWCAVE "A multidisciplinary research project to study, classify and mitigate the environmental impact in tourist caves" (project number 2017HTXT2R; funded by the Italian Ministry of Education, University and Research).
DOI: 10.5281/zenodo.7330158
title: Data for "Let's not wing it: Effective conservation of subterranean-roosting bats"

description: Database as both excel (.xls) and tab-delimited (.csv) associated with the publication: 


Meierhofer M.B., et al. (2023) Let’s not wing it: Effective conservation of subterranean-roosting bats. Conservation biology.


Please refer to the main publication for a detailed description. An explanation of the database is available in the Metadata file uploaded alongside the database. R code to reproduce the analysis pipeline is available on GitHub:


https://github.com/StefanoMammola/Analysis_Cave_bat_conservation.git
description: Additional support is provided by Biodiversa+ 2021–2022 Join call, through the project "DarCo: The vertical dimension of conservation: A cost-effective plan to incorporate subterranean ecosystems in post-2020 biodiversity and climate change agendas", by the Academy of Finland (no. 339265 and 331515), by Kone Foundation (no. 202007611), and by Brazilian CNPq (grant no. 306574/2020-9)
DOI: 10.6084/m9.figshare.16969316.v1
title: Additional file 1 of Patterns and timing of recurrence in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiotherapy plus esophagectomy

description: Additional file 1.
DOI: 10.6084/m9.figshare.16461527
title: Anterior nasal versus nasal mid-turbinate sampling for a SARS-CoV-2 antigen-detecting rapid test: does localisation or professional collection matter?

description: Most SARS-CoV-2 antigen-detecting rapid diagnostic tests require nasopharyngeal sampling, which is frequently perceived as uncomfortable and requires healthcare professionals, thus limiting scale-up. Nasal sampling could enable self-sampling and increase acceptability. The term nasal sampling is often not used uniformly and sampling protocols differ. This manufacturer-independent, prospective diagnostic accuracy study, compared professional anterior nasal and nasal mid-turbinate sampling for a WHO-listed SARS-CoV-2 antigen-detecting rapid diagnostic test. The second group of participants collected a nasal mid-turbinate sample themselves and underwent a professional nasopharyngeal swab for comparison. The reference standard was real-time polymerase chain reaction (RT-PCR) using combined oro-/nasopharyngeal sampling. Individuals with high suspicion of SARS-CoV-2 infection were tested. Sensitivity, specificity, and percent agreement were calculated. Self-sampling was observed without intervention. Feasibility was evaluated by observer and participant questionnaires. Among 132 symptomatic adults, both professional anterior nasal and nasal mid-turbinate sampling yielded a sensitivity of 86.1% (31/36 RT-PCR positives detected; 95%CI: 71.3–93.9) and a specificity of 100.0% (95%CI: 95.7–100). The positive percent agreement was 100% (95%CI: 89.0–100). Among 96 additional adults, self nasal mid-turbinate and professional nasopharyngeal sampling yielded an identical sensitivity of 91.2% (31/34; 95%CI 77.0–97.0). Specificity was 98.4% (95%CI: 91.4–99.9) with nasal mid-turbinate and 100.0% (95%CI: 94.2–100) with nasopharyngeal sampling. The positive percent agreement was 96.8% (95%CI: 83.8–99.8). Most participants (85.3%) considered self-sampling as easy to perform. Professional anterior nasal and nasal mid-turbinate sampling are of equivalent accuracy for an antigen-detecting rapid diagnostic test in ambulatory symptomatic adults. Participants were able to reliably perform nasal mid-turbinate sampling themselves, following written and illustrated instructions. Nasal self-sampling will facilitate scaling of SARS-CoV-2 antigen testing.
DOI: 10.6084/m9.figshare.20115435
title: Additional file 1 of Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis

description: Additional file 1.
DOI: 10.6084/m9.figshare.20115438
title: Additional file 2 of Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis

description: Additional file 2.
DOI: 10.6084/m9.figshare.20115755
title: Additional file 1 of Posterior scleral reinforcement for the treatment of myopic traction maculopathy

description: Additional file 1.