cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3843315
title: Original data sheet from Respiratory modulation of startle eye blink: a new approach to assess afferent signals from the respiratory system

description: Current approaches to assess interoception of respiratory functions cannot differentiate between the physiological basis of interoception, i.e. visceral-afferent signal processing and the psychological process of attention focusing. Furthermore, they typically involve invasive procedures, e.g. induction of respiratory occlusions or the inhalation of CO<sub>2</sub>-enriched air. The aim of this study was to test the capacity of startle methodology to reflect respiratory-related afferent signal processing, independent of invasive procedures. Forty-two healthy participants were tested in a spontaneous breathing and in a 0.25 Hz paced breathing condition. Acoustic startle noises of 105 dB(A) intensity (50 ms white noise) were presented with identical trial frequency at peak and on-going inspiration and expiration, based on a new pattern detection method, involving the online processing of the respiratory belt signal. The results show the highest startle magnitudes during on-going expiration compared with any other measurement points during the respiratory cycle, independent of whether breathing was spontaneous or paced. Afferent signals from slow adapting phasic pulmonary stretch receptors may be responsible for this effect. This study is the first to demonstrate startle modulation by respiration. These results offer the potential to apply startle methodology in the non-invasive testing of interoception-related aspects in respiratory psychophysiology.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.6084/m9.figshare.3843315.v1
title: Original data sheet from Respiratory modulation of startle eye blink: a new approach to assess afferent signals from the respiratory system

description: Current approaches to assess interoception of respiratory functions cannot differentiate between the physiological basis of interoception, i.e. visceral-afferent signal processing and the psychological process of attention focusing. Furthermore, they typically involve invasive procedures, e.g. induction of respiratory occlusions or the inhalation of CO<sub>2</sub>-enriched air. The aim of this study was to test the capacity of startle methodology to reflect respiratory-related afferent signal processing, independent of invasive procedures. Forty-two healthy participants were tested in a spontaneous breathing and in a 0.25 Hz paced breathing condition. Acoustic startle noises of 105 dB(A) intensity (50 ms white noise) were presented with identical trial frequency at peak and on-going inspiration and expiration, based on a new pattern detection method, involving the online processing of the respiratory belt signal. The results show the highest startle magnitudes during on-going expiration compared with any other measurement points during the respiratory cycle, independent of whether breathing was spontaneous or paced. Afferent signals from slow adapting phasic pulmonary stretch receptors may be responsible for this effect. This study is the first to demonstrate startle modulation by respiration. These results offer the potential to apply startle methodology in the non-invasive testing of interoception-related aspects in respiratory psychophysiology.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.6084/m9.figshare.3843312
title: SPSS behavioral EEG data from Changes in interoceptive processes following brain stimulation

description: The processing and perception of individual internal bodily signals (interoception) has been differentiated to comprise different levels and processes involved. The so-called heartbeat-evoked potential (HEP) offer an additional possibility to examine automatic processing of cardiac signals. Knowledge on neural structures potentially supporting different facets of interoception is still sparse. One way to get insights into neuroanatomical function is to manipulate the activity of different brain structures. In this study, we used repetitive transcranial magnetic stimulation (rTMS) and a continuous theta-burst protocol to inhibit specific central locations of the interoceptive network including the right anterior insula and the right somatosensory cortices and assessed effects on interoceptive facets and the HEP in 18 male participants. Main results were that inhibiting anterior insula resulted in a significant decline in cardiac and respiratory interoceptive accuracy (IAc) and in a consistent decrease in perception confidence. Continuous theta-burst stimulation (cTBS) over somatosensory cortices reduced only cardiac IAc and affected perception confidence. Inhibiting right anterior insula and right somatosensory cortices increased interoceptive sensibility and reduced the HEP amplitude over frontocentral locations. Our findings strongly suggest that cTBS is an effective tool to investigate the neural network supporting interoceptive processes.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.7910/dvn/v1rjpf/szjpfo
title: mea20151215_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843312.v1
title: SPSS behavioral EEG data from Changes in interoceptive processes following brain stimulation

description: The processing and perception of individual internal bodily signals (interoception) has been differentiated to comprise different levels and processes involved. The so-called heartbeat-evoked potential (HEP) offer an additional possibility to examine automatic processing of cardiac signals. Knowledge on neural structures potentially supporting different facets of interoception is still sparse. One way to get insights into neuroanatomical function is to manipulate the activity of different brain structures. In this study, we used repetitive transcranial magnetic stimulation (rTMS) and a continuous theta-burst protocol to inhibit specific central locations of the interoceptive network including the right anterior insula and the right somatosensory cortices and assessed effects on interoceptive facets and the HEP in 18 male participants. Main results were that inhibiting anterior insula resulted in a significant decline in cardiac and respiratory interoceptive accuracy (IAc) and in a consistent decrease in perception confidence. Continuous theta-burst stimulation (cTBS) over somatosensory cortices reduced only cardiac IAc and affected perception confidence. Inhibiting right anterior insula and right somatosensory cortices increased interoceptive sensibility and reduced the HEP amplitude over frontocentral locations. Our findings strongly suggest that cTBS is an effective tool to investigate the neural network supporting interoceptive processes.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.7910/dvn/v1rjpf/4h5r6j
title: mea20160908_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/bx1hbe
title: mea20161217_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/lvdqcu
title: mea20160331_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/kosxi7
title: mea20150712_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/66fwap
title: mea20160217_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843282
title: Summary of available data from Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

description: Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout the vast interoceptive network. To this end, we obtained relevant measures of cardiac interoception in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal brain damage: behavioural variant fronto-temporal dementia (bvFTD), Alzheimer's disease (AD) and fronto-insular stroke. Neural correlates of the three dimensions were examined through structural and functional resting-state imaging, and online measurements of the heart-evoked potential (HEP). The three patient groups presented deficits in interoceptive accuracy, associated with insular damage, connectivity alterations and abnormal HEP modulations. Interoceptive learning was differentially impaired in AD patients, evidencing a key role of memory networks in this skill. Interoceptive awareness results showed that bvFTD and AD patients overestimated their performance; this pattern was related to abnormalities in anterior regions and associated networks sub-serving metacognitive processes, and probably linked to well-established insight deficits in dementia. Our findings indicate how damage to specific hubs in a broad fronto-temporo-insular network differentially compromises interoceptive dimensions, and how such disturbances affect widespread connections beyond those critical hubs. This is the first study in which a multiple lesion model reveals fine-grained alterations of body sensing, offering new theoretical insights into neuroanatomical foundations of interoceptive dimensions.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.7910/dvn/v1rjpf/ipeys7
title: mea20151006_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843282.v1
title: Summary of available data from Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

description: Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout the vast interoceptive network. To this end, we obtained relevant measures of cardiac interoception in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal brain damage: behavioural variant fronto-temporal dementia (bvFTD), Alzheimer's disease (AD) and fronto-insular stroke. Neural correlates of the three dimensions were examined through structural and functional resting-state imaging, and online measurements of the heart-evoked potential (HEP). The three patient groups presented deficits in interoceptive accuracy, associated with insular damage, connectivity alterations and abnormal HEP modulations. Interoceptive learning was differentially impaired in AD patients, evidencing a key role of memory networks in this skill. Interoceptive awareness results showed that bvFTD and AD patients overestimated their performance; this pattern was related to abnormalities in anterior regions and associated networks sub-serving metacognitive processes, and probably linked to well-established insight deficits in dementia. Our findings indicate how damage to specific hubs in a broad fronto-temporo-insular network differentially compromises interoceptive dimensions, and how such disturbances affect widespread connections beyond those critical hubs. This is the first study in which a multiple lesion model reveals fine-grained alterations of body sensing, offering new theoretical insights into neuroanatomical foundations of interoceptive dimensions.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.7910/dvn/v1rjpf/u9xboo
title: mea20160203_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/djsqr9
title: mea20150902_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/paqerw
title: mea20151026_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843252
title: Supplementary Information from A touch of sleep: biophysical model of contact-mediated dormancy of archaea by viruses

description: The canonical view of the interactions between viruses and their microbial hosts presumes that changes in host and virus fate require the initiation of infection of a host by a virus. Infection may lead to the death of the host cell and release of viruses, to the elimination of the viral genome through cellular defense mechanisms, or the integration of the viral genome with the host as a chromosomal or extra-chromosomal element. Here we revisit this canonical view, inspired by recent experimental findings in which the majority of target host cells can be induced into a dormant state when exposed to either active or de-activated viruses, even when viruses are present at low relative titer. We propose that both the qualitative phenomena and the quantitative time-scales of dormancy induction are consistent with the hypothesis that cellular physiology can be altered by <i>contact</i> on the surface of host cells rather than strictly by <i>infection</i>. In order to test this hypothesis, we develop and study a biophysical model of contact-mediated dynamics involving virus particles and target cells. We show how virus particles can catalyze cellular transformations amongst many cells, even if they ultimately infect only one (or none). We also find that population-scale dormancy is robust to variation in the representation of model dynamics, including cell growth, death, and recovery.
DOI: 10.6084/m9.figshare.3843252.v1
title: Supplementary Information from A touch of sleep: biophysical model of contact-mediated dormancy of archaea by viruses

description: The canonical view of the interactions between viruses and their microbial hosts presumes that changes in host and virus fate require the initiation of infection of a host by a virus. Infection may lead to the death of the host cell and release of viruses, to the elimination of the viral genome through cellular defense mechanisms, or the integration of the viral genome with the host as a chromosomal or extra-chromosomal element. Here we revisit this canonical view, inspired by recent experimental findings in which the majority of target host cells can be induced into a dormant state when exposed to either active or de-activated viruses, even when viruses are present at low relative titer. We propose that both the qualitative phenomena and the quantitative time-scales of dormancy induction are consistent with the hypothesis that cellular physiology can be altered by <i>contact</i> on the surface of host cells rather than strictly by <i>infection</i>. In order to test this hypothesis, we develop and study a biophysical model of contact-mediated dynamics involving virus particles and target cells. We show how virus particles can catalyze cellular transformations amongst many cells, even if they ultimately infect only one (or none). We also find that population-scale dormancy is robust to variation in the representation of model dynamics, including cell growth, death, and recovery.
DOI: 10.7910/dvn/v1rjpf/bxna9y
title: mea20160129_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/b6iauw
title: mea20150706_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/evxmi6
title: mea20150307_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/mlxtls
title: mea20150115_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/p6lhlf
title: mea20150530_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ruzrsw
title: mea20150701_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vn4zhg
title: mea20150617_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/b7rabl
title: mea20151028_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/c20tvv
title: mea20150107_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/zlywok
title: mea20160114_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/wdkfdj
title: mea20160529_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/soavmz
title: mea20160218_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843195
title: Protection of endothelial cells against Ang II-induced impairment: Involvement of both PPARα and PPARγ via PI3K/Akt pathway

description: The aim of our study is to explore the involvement of PPARα and PPARγ in Ang II-induced endothelial injury. We found that Ang II significantly elevated the oxidative stress in HUVECs, causing apoptosis and cellular impairment in a time-dependent pattern. Activation of either PPARα by docosahexaenoic acid (DHA) or PPARγ by rosiglitazone protected the endothelial cells. Interestingly, a more significant effect was observed when DHA and rosiglitazone were administrated together. Moreover, we found that this protection was mediated through the PI3K/Akt pathway. Our study may help to understand the mechanism of endothelial dysfunction, contributing to the treatment of hypertension and other endothelial-related diseases.
DOI: 10.6084/m9.figshare.3843195.v1
title: Protection of endothelial cells against Ang II-induced impairment: Involvement of both PPARα and PPARγ via PI3K/Akt pathway

description: The aim of our study is to explore the involvement of PPARα and PPARγ in Ang II-induced endothelial injury. We found that Ang II significantly elevated the oxidative stress in HUVECs, causing apoptosis and cellular impairment in a time-dependent pattern. Activation of either PPARα by docosahexaenoic acid (DHA) or PPARγ by rosiglitazone protected the endothelial cells. Interestingly, a more significant effect was observed when DHA and rosiglitazone were administrated together. Moreover, we found that this protection was mediated through the PI3K/Akt pathway. Our study may help to understand the mechanism of endothelial dysfunction, contributing to the treatment of hypertension and other endothelial-related diseases.
DOI: 10.7910/dvn/v1rjpf/d9cpfn
title: mea20150529_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843060
title: Nasal contact points data table

description: Table S1 . Detailed summary of all data obtained for each of the 50 dogs included in this study
DOI: 10.7910/dvn/v1rjpf/vc7s12
title: mea20160923_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843060.v2
title: Nasal contact points data table

description: Table S1 . Detailed summary of all data obtained for each of the 50 dogs included in this study
DOI: 10.7910/dvn/v1rjpf/emcc0t
title: mea20160225_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843060.v1
title: Nasal contact points data table v2.xlsx

description: Table S1 . Detailed summary of all data obtained for each of the 50 dogs included in this study
DOI: 10.7910/dvn/v1rjpf/mmpm8c
title: mea20150301_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/7boi6n
title: mea20161025_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/wxhvma
title: mea20151124_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/jjslxo
title: mea20150126_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/y7sfzy
title: mea20160810_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/f6ugwp
title: mea20150922_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3rjzzo
title: mea20160825_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/thur2c
title: mea20150914_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/240okj
title: mea20151011_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/fetcu7
title: mea20150927_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843012
title: Correlation Between # of Plant Species and % of Vegetation and Grassland Coverage in an Open Field at York University

description: This study examines the relationship between the amount of plant species present in a quadrat that also compares the percentage of vegetation versus grasslands in an open field located by a body of water at York University. <b>Methods</b> In pairs, a quadrat was used to collect data in an open field filled with various plant species. The quadrat was thrown and placed 25 times to collect data of the total # of species, the total % of vegetation cover, the total % of grassland cover and total # individuals present within the quadrat. For each trial, the distance was measured from the previous quadrat location. The data was recorded onto an excel sheet and uploaded to Figshare (table above). <b>Hypothesis</b> There will be a positive correlation between the amount individuals present and % of vegetation covered within the quadrat. <b>Prediction</b> There will be a positive correlation between the amount of individuals present and the % of vegetation covered within the quadrat as the % of vegetation coverage increases, the higher the probability more individuals will be present. If the vegetation coverage exceeds the grassland coverage, more species will be viable to live in the quadrat thus producing more individuals. Therefore, having a greater vegetation coverage than grassland leads to the growth of individuals of the species present. <b>Metadata</b>- 25 quadrat measurements were taken place all at random and different locations<br> - The distance was measured from each quadrat to ensure a diverse sample of data collected. Data is quantitative.- Total # of species present = 8 different species were present in the open field located at York University. Data is quantitative.- Total # of individuals present = the amount of living flowers that were not damaged or wilted from natural causes. Data is quantitative. - Total % of Vegetation and Grassland Coverage = the area calculated within the quadrat comparing vegetation and grassland. Data is quantitative.<br>
DOI: 10.7910/dvn/v1rjpf/3lkrx2
title: mea20150619_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843012.v1
title: Correlation Between # of Plant Species and % of Vegetation and Grassland Coverage in an Open Field at York University

description: This study examines the relationship between the amount of plant species present in a quadrat that also compares the percentage of vegetation versus grasslands in an open field located by a body of water at York University. <b>Methods</b> In pairs, a quadrat was used to collect data in an open field filled with various plant species. The quadrat was thrown and placed 25 times to collect data of the total # of species, the total % of vegetation cover, the total % of grassland cover and total # individuals present within the quadrat. For each trial, the distance was measured from the previous quadrat location. The data was recorded onto an excel sheet and uploaded to Figshare (table above). <b>Hypothesis</b> There will be a positive correlation between the amount individuals present and % of vegetation covered within the quadrat. <b>Prediction</b> There will be a positive correlation between the amount of individuals present and the % of vegetation covered within the quadrat as the % of vegetation coverage increases, the higher the probability more individuals will be present. If the vegetation coverage exceeds the grassland coverage, more species will be viable to live in the quadrat thus producing more individuals. Therefore, having a greater vegetation coverage than grassland leads to the growth of individuals of the species present. <b>Metadata</b>- 25 quadrat measurements were taken place all at random and different locations<br> - The distance was measured from each quadrat to ensure a diverse sample of data collected. Data is quantitative.- Total # of species present = 8 different species were present in the open field located at York University. Data is quantitative.- Total # of individuals present = the amount of living flowers that were not damaged or wilted from natural causes. Data is quantitative. - Total % of Vegetation and Grassland Coverage = the area calculated within the quadrat comparing vegetation and grassland. Data is quantitative.<br>