cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21079531.v1
title: Supplementary Material for: Associations between <b><i>TNFAIP3</i></b> Polymorphisms and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Update with Trial Sequential Analysis

description: <b><i>Introduction:</i></b> The tumor necrosis factor alpha inducible protein 3 (<i>TNFAIP3</i>) gene produces ubiquitin-editing protein A20, which inhibits nuclear factor-κB (NF-κB) activation in a variety of signaling pathways. We examined the association between <i>TNFAIP3</i> polymorphisms and rheumatoid arthritis (RA) susceptibility. <b><i>Methods:</i></b> MEDLINE, Embase, Scopus, and Web of Science were searched for available articles on <i>TNFAIP3</i> polymorphisms in RA patients from inception until July 11, 2022. We included case-control studies on the association between rs2230926 and rs5029937 polymorphisms of <i>TNFAIP3</i> and RA, and we excluded studies that contained overlapping data. We scored the quality of each study included based on the Newcastle-Ottawa Scale. Meta-analyses evaluated the association between <i>TNFAIP3</i> polymorphisms and RA susceptibility in diverse ethnic populations and was verified through trial sequential analysis (TSA). This meta-analysis was registered in the PROSPERO register (number: CRD42022345160). There was no funding source. <b><i>Results:</i></b> Seventeen studies were chosen for meta-analysis. Ten studies for rs2230926, and seven for rs5029937. An association was noted between <i>TNFAIP3</i> rs2230926 G allele and RA in all subjects (odds ratio [OR] = 1.389; 95% confidence interval [CI] = 1.161−1.662; <i>p</i> &lt; 0.001). Ethnicity-specific analysis showed significant association of rs2230926 G allele with RA in Europeans and Asians (OR = 1.642; 95% CI = 1.099–2.452; <i>p</i> = 0.015; OR = 1.404; 95% CI = 1.262−1.562; <i>p</i> &lt; 0.001). An association was also noted between <i>TNFAIP3</i> rs5029937 T allele and RA in all subjects (OR = 1.389; 95% CI = 1.207−1.785; <i>p</i> &lt; 0.001). An ethnicity-specific meta-analysis revealed a significant association of the rs5029937 T allele with RA in Europeans and Asians. Dominant model analysis showed the same pattern for <i>TNFAIP3</i> rs2230926 G and rs5029937 T alleles in Europeans and Asians, suggesting an association between rs2230926 G and rs5029937. TSA indicated a robust association between the <i>TNFAIP3</i> polymorphisms and the risk of RA. <b><i>Conclusion:</i></b> <i>TNFAIP3</i> rs2230926 and rs5029937 polymorphisms are associated with RA susceptibility in European and Asian populations. However, the data were not stratified by parameters such as rheumatoid factor status, disease activity, or environmental variables.
DOI: 10.6084/m9.figshare.21079567.v1
title: Supplementary Material for: Prevalence and Correlates of Embitterment in a National Representative Sample

description: <b><i>Introduction:</i></b> Embitterment may occur after stressful but normal life events, such as job loss, divorce, or unjust events. Embitterment is a normal affect, but it may become clinically relevant in case it becomes very strong and long-lasting, and impairs daily functioning. <b><i>Objective:</i></b> Until now, no epidemiological data on the frequency of high embitterment in the general population have been available. <b><i>Methods:</i></b> A national representative survey of 2,531 people was carried out in Germany in 2019. The participants gave ratings for their embitterment due to perceived events (Posttraumatic Embitterment Scale), their psychological capacity profile (Mini-ICF-APP-S), sick leave duration, and sociodemographics. <b><i>Results:</i></b> About 11.7% of the investigated representative population report moderate embitterment, and another 3.8% high embitterment. Embitterment was only low correlated with other psychopathology, here work anxiety (<i>r</i> = 0.281**). There are no differences between embittered and nonembittered in respect to age, sex, household members, and professional distribution. Those with the highest embitterment have been unemployed more often and have lower income. At least 7.2% of those with high embitterment have a severe psychological capacity impairment and are in need of support by thirds to fulfill daily duties. In 55% of the 802 who reported a stressful event, injustice by an important person has been reported. Injustice by an institution (14%) or societal injustice (12%) was least often reported as a relevant stressful event. <b><i>Conclusion:</i></b> Physicians, therapists, and public health must be aware of embitterment as a specific mental health problem which occurs frequently and may become chronic with work and life participation problems.
DOI: 10.6084/m9.figshare.21079591.v1
title: Supplementary Material for: Extended Pelvic Lymph Node Dissection Does Not Affect Functional Outcomes during Bilateral Nerve-Sparing Radical Prostatectomy

description: <b><i>Introduction:</i></b> A possible association between extended pelvic lymph node dissection (ePLND) in radical prostatectomy (RPE) and functional outcomes such as erectile function (EF) and continence recovery has been previously considered. This association stems from the direct proximity of ePLND to the pelvic plexus. In this paper, we aimed to critically examine an association of ePLND with functional outcomes in patients who underwent bilateral nerve-sparing RPE. <b><i>Methods:</i></b> 272 out of 782 patients from a randomized, patient-blinded, multicenter trial were retrospectively classified into two groups based on the D’Amico criteria: 114 had no PLND and 158 had ePLND. Continence (no pad/safety pad) and EF (Index of Erectile Function-5 [IIEF-5] questionnaire ≥17; sufficient erection for sexual intercourse) were assessed at 3, 6, and 12 months as well as postsurgical complications (Clavien-Dindo Classification). <b><i>Results:</i></b> After 12 months of follow-up, no significant difference for potency could be found between men without and subjected to ePLND: IIEF-5 ≥17 (23.2% vs. 27.2%; <i>p</i> = 0.55) and sufficient erection for intercourse (44.1% vs. 45.6%; <i>p</i> = 0.84). A multiple linear regression analysis demonstrated that while preoperative EF (<i>p</i> &lt; 0.001), pathological tumor stage (<i>p</i> = 0.027), and robot-assisted bilateral nerve-sparing RPE (<i>p</i> &lt; 0.001) were independent predictors of EF recovery, the same did not apply to ePLND. No association was detected for continence recovery (94.2% vs. 89.7%; <i>p</i> = 0.22) and complications of any grade after surgery (11.4% vs. 16.5%; <i>p</i> = 0.24). <b><i>Conclusion:</i></b> ePLND is not associated with increased risk of erectile dysfunction, incontinence or complications after bilateral nerve-sparing RPE.
DOI: 10.15151/esrf-es-874716752
title: The Netherlands BAG

description: The Netherlands BAG includes groups situated at five Dutch universities (Utrecht, Groningen, Amsterdam, Wageningen and Eindhoven) and at the Netherlands Cancer Institute in Amsterdam, with a total of twelve PIs. The structural biology research carried out in these groups is highly diverse, including prokaryotic and eukaryotic proteins with a strong focus on targets and processes of biomedical relevance. Central to many projects are protein receptors and their interactions with other proteins and with small molecule modulators. An additional major research area concerns structure-based protein engineering and design aiming at the characterization and engineering of new enzymes for green chemistry and new-to-nature reactions. Projects deal with membrane and soluble proteins, cell surface receptors, and protein-protein, protein-ribonucleotide, protein-drug and enzyme-ligand complexes.
DOI: 10.15151/esrf-es-921493013
title: Exploring the local structure of carbonate minerals to shed light on the carbon cycle

description: Carbonate minerals are present not only in the Earth crust, but even in the deeper part of our planet, being involved in the carbon cycle. In this view, we selected BaCO3 (witherite) and SrCO3 (strontianite), which exhibit the RT structure of aragonite. Upon temperature increase, these two minerals show phases transitions, that for now, were studied only taking into account the average structure. Interestingly, no structural analysis on the local structure by Pair Distribution Function (PDF) has ever been considered .To determine a link between the local structure and their behaviours upon heating, we propose an investigation using total scattering data collection. BaCo3 and SrCO3 will be investigated as well as their calcium counterpart (calcite and aragonite). Results will allow us to obtain a structural characterization of the average and local structure giving new insight into the evolution of these minerals as a function of the temperature and their role in the carbon cycle.
DOI: 10.15151/esrf-es-893681479
title: A time-resolved SAXS/WAXS study of super-structure formation in glycyrrhizin-based wound healing hydrogels

description: Glycyrrhizin (GA) containing hydrogels are used in wound healing applications since the GA increases the wound healing speed. GA forms hydrogels by an entropically-driven self-assembly into large cross-linked structures in water.1 These large structures are rapidly formed and contain fibrillar building blocks.2 Up to now, it is unclear how these fibrils self-assemble into larger constructs and how they can form crosslinked domains. As the self-assembly of GA gels happens within minutes fast recording is crucial to understand this process.3 When using these gels in wound healing applications, the gel strength is important for the gel to remain on the wound while glycerrhizin is released into the wound environment. Therefore, a study of the structure kinetics and structure evolution during the self-assembly process is essential to link with biological effects in wound healing processes.
DOI: 10.15151/esrf-es-921331412
title: Continuation - Activating a novel (Bi2O3/Bi) tandem catalyst for CO2 conversion: an operando XRD/tomography approach (CH6079)

description: we will perform post mortem XRD-CT on some Bi2O3 samples to identify the location of the oxide, metal and carbonate after reaction
DOI: 10.15151/esrf-es-922605330
title: Accumulation based, XRF Ghost Imaging acquisitions

description: X-ray Fluorescence (XRF) Ghost Imaging (GI) is an emerging imaging technique, that promises compelling advantages in terms of spatial resolution, and dose deposition on the samples. Its implementation has been proven on laboratory sources [1], but it has been hard to implement on synchrotron sources so far. So far, all attempts have used a so-called Computational GI approach. This approach suffers from multiple limitations: flat-field and intensity discrepancies between XRF and mask measurements, drifts in the masks positions, and non-ideal response of the beam intensity monitors. In the proposed experiment, we will develop a new XRF GI acquisition scheme that overcomes the above mentioned limitations. We will develop new acquisition setup and control scheme, in order to simultaneously acquire XRF and mask measurements. This will remove discrepancies between measurements, and reliable intensity monitoring. [1] 10.1364/OPTICA.441682
DOI: 10.15151/esrf-es-924289398
title: cross-sectional scanning diffraction tests on FeCr alloys and silicon chips in EH3

description: cross-sectional scanning diffraction tests on FeCr alloys and silicon chips in EH3
DOI: 10.15151/esrf-es-892737622
title: Local structural correlations in heavy rare-earth zirconates A2Zr2O7

description: Rare-earth A2Zr2O7 zirconates have been generally considered to crystallize with either long range ordered pyrochlore structure or disordered defect-fluorite structure, empirically depending on the size ratio between A and Zr cations. However, on a local scale, the ‘defect-fluorite’ members of the series have been discussed to reveal a lower-symmetry structure. Recently, our neutron and x-ray pair-distribution function studies of local structure correlations in the series suggested that the short-range environment of the nominally ‘defect-fluorite’ members is similar to the rhombohedral structure of the end-member Lu2Zr2O7. To unambiguously reveal subtle structural aspects in the A2Zr2O7 series, our PDF results are still to be corroborated by other local-environment sensitive techniques, namely the proposed EXAFS experiment.
DOI: 10.15151/esrf-es-922494635
title: Characterization of CoO phase transition via DFXM technique

description: We will observe the evolution of the hkl reflections of choice from room temperature, where CoO shows rock salt structure, to a target temperature below TN (293 K). The temperature will be controlled through external cooling using a N2 cryo-stream. The study will be performed through RSM and imaging of the 3D structure of the CoO sample trough mosaicity and strain maps in the ID06-HXM beamline in transmission mode. The single crystals are 5 mm x 5 mm x 50 um . The investigated reflections are the (100) and (111).
DOI: 10.15151/esrf-es-892042898
title: Interaction of Prohibitin with the inner of mitochondrial membrane

description: Prohibitin (PHB) is a heterodimer forming a multimeric ring in the intermembrane space at the inner mitochondrial membrane. PHB directs the cell’s energy production. Each of the two PHBs has an N-terminal helix thought to anchor the protein to the membranes. Our aim is to characterize the anchoring of PHB to the membrane by studying the two peptides corresponding to the intermembrane sequences of the dimer. Preliminary results collected showed the importance of lipid membrane composition in particular cardiolipin (CL, present at high concentration in mitochondrial membranes), but led to 3 unexpected findings: a seemingly opposite action of both N-terminal helices, slow kinetics of interaction, and concentration-threshold effects. The X-ray reflectivity experiment we propose for ID10 will (i) locate and quantify the 2 N-terminal helices in the membrane at various incubation times, (ii) elucidate possible synergisms between the peptides and (iii) resolve the role of CL.
DOI: 10.15151/esrf-es-892042933
title: Multiscale and multimodal characterization of polycrystal plasticity in metallic materials

description: This proposal will develop, and make available to the user community, a new experimental and algorithmic framework to conduct simulation informed multi-modal in situ experiments on metallic materials. This will allow to study the mechanical behaviour of polycrystalline samples at the microstructural scale (deformation, fracture). The establishment of automated acquisition and data processing pipelines will allow for the first time to use the feedback from experimentally driven simulations of the material response to guide subsequent “zoom-in” observations in selected regions of interest. Achieving this ambitious goal requires (i) a new, fully integrated, in situ load stage compatible with both id11 end stations (ii) an efficient data processing pipeline for DCT, topotomography and scanning-3DXRD acquisitions (both interactive & automated) and (iii) experimentally driven mechanical simulation routines to add stress/strain fields to the reconstructed data.
DOI: 10.15151/esrf-es-879445008
title: Structural analysis of historical materials

description: This proposal aims at implementing a new access route to the ESRF structural analysis capacities for the Heritage Science community. The upgrade to the ESRF-EBS was the triggering element to propose a single block allocation group (BAG). After discussion with multiple interested research teams, it was decided to target two complementary analytical configurations at the ESRF: High angular resolution XRD (ID22) and High lateral resolution XRD (ID13). The combination of these two beamlines generates precious clues on the origin, processing and degradation of historical materials. The new analytical capacities of the EBS, combined with an optimized access route is expected to increase the output of the Cultural Heritage community, to reinforce a scientific network of expert users structured around the ESRF, and to initiate new European collaborations in Heritage Science.
DOI: 10.15151/esrf-es-891425094
title: Domain structures in PbTiO3/SrTiO3 superlattices on DyScO3

description: Recently ferroelectric superlattices have emerged as the main platform for exploring novel polarization textures, such as polar vortices, skymion bubbles and supercrystal phases, and novel functionalities, such as negative capacitance [4,5]. Although state-of-the-art scanning transmission electron microscopy can provide useful information about the local polarization, much less is known about the response of these novel polar structures to temperature and applied electric field. To this end, we propose to use in-situ scanning x-ray diffraction microscopy (SXDM) at ID01 to study the evolution under applied field, at various temperatures, of the unusual domain structure appearing in in-plane polarised PbTiO3/SrTiO3 (PTO/STO) superlattices grown on DyScO3 substrates.
DOI: 10.15151/esrf-es-891425217
title: In-plane and out-of-plane structural analysis of epitaxial 2D MoS2 thin films MOCVD-grown on distinct Al2O3(0001) surfaces

description: This proposal aims to investigate epitaxial, 2D thin films of MoS2, a prototypical transition-metal dichalcogenide (TMD) semiconductor with potential applications in nanoelectronics. Single-layers of MoS2 have been grown by metal-organic chemical vapor deposition (MOCVD) on sapphire (α-Al2O3) substrates with distinct O-terminated (1×1) and Al-terminated (√31×√31)R9° surface reconstructions. To better understand the distinct growth behaviour and epitaxial model, a detailed structural analysis of the surfaces and interfaces is proposed by in-plane GIXD and out-of-plane XRR studies. Moreover, an in situ study involving thermal annealing of MoS2/Al2O3 samples in H2S-atmosphere can simulate S-rich reaction conditions and monitor evolution of the topmost sapphire surface and MoS2/Al2O3 interface. These experiments will gain a fundamental understanding of the impact of sapphire surface reconstruction, which is expected to play a crucial role in the vdW epitaxy of TMDs.
DOI: 10.15151/esrf-es-891425343
title: Unravelling a photoinduced compressive lattice response in the canonical Mott insulator (V1-xCrx)2O3

description: This proposal aims at determining the nature of lattice strain, compressive vs tensile, following the ultrafast photoexcitation of hot carriers in the canonical Mott insulator (V1-xCrx)2O3. Our recent µ-XRD mapping on (V0.95Cr0.05)2O3 thin films after an electric field-driven insulator to metal transition indeed revealed a compressive lattice response. As electric field and light pulses are both prone to generate hot carriers, we might expect that photoexcitation would also induce a compressive lattice response in (V1 - xCrx)2O3. Our preliminary pump-probe reflectivity study in (V0.95Cr0.05)2O3 films is consistent with this view. Overall this study might challenge the paradigm by which photoexcitation of matter always leads to a thermally-driven expansion, and suggest that Mott physics can lead to a reverse compressive behavior. This study is part of the MOTT-IA project, which aims at creating the first hardware neural network based on the properties of Mott insulators.
DOI: 10.15151/esrf-es-891427886
title: Towards Rational Understanding of the Fe-quarterpyridine-mediated CO2 Reduction Reaction

description: A renewable and clean energy economy is a societal challenge that has become one of the main concerns during last decades because of the implication of fossil fuels in global warming and climate change. Artificial photosynthesis is one of the most promising alternatives. In our group, we have prepared the recently reported [FeII(qpy)(H2O)2]2 with the objective of fully understanding the mechanism of the CO2 reduction to CO. Within this context, Kβ XES, HERFD, VtC XES techniques, are powerful techniques that can provide unique mechanistic information of this system, helping for the future design of not only qpy-based, but also other CO2 reduction catalysts.
DOI: 10.15151/esrf-es-886076657
title: Magnetic properties in the single molecular magnet TbPc2 insulating ferromagnet EuO2 system.

description: TbPc2 molecules are single molecular magnets (SMM) considered as of possible Qubis realizations in future quantum computing technology and for spinterfaces, spin filtering systems in semiconductors. Metallic substrates are well studied for these molecules but destroy most of the SMM properties. Insulating substrates like MgO are better suited for this purpose revealing coercive fields up to 2 T. Here we will investigate a ferromagnetic semiconducting surface, EuO. This surface is relatively stable in UHV conditions and will be prepared on-site. The magnetic properties of TbPc2 will be investigated on top of this surface.
DOI: 10.5519/qd.zks9jfsg
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (35 records)
DOI: 10.5519/qd.uiq78hwa
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (5275962 records)
DOI: 10.5519/qd.8lgxnh6t
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (8681 records)
DOI: 10.5519/qd.0swz23qn
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (5832 records)
DOI: 10.5519/qd.md271f9t
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (100 records)
DOI: 10.34740/kaggle/dsv/4191923
title: Contrastive Language Image Pretraining by openai
DOI: 10.21227/eqs0-wy86
title: test

description: test d
DOI: 10.25919/y05z-6p25
title: Parkes observations for project P1105 semester 2021APRS_19

description: We have re-processed all the observations in the Parkes pulsar data archive obtained during the first four years of the Parkes multibeam receiver and have developed a new artificial intelligence (AI) algorithm to investigate huge volume of candidates. Except for our previous detections, the latest results include 87 new fast radio burst (FRB) candidates with S/N above 7. These signals were only detected in a single beam of the receiver suggesting that they are unlikely to be terrestrial. Their dispersion measure (DM) excesses over the estimated Galactic DM place them at extragalactic distances. Using the Ultra Wideband Low (UWL) receiver we have opportunity to detect repeating signals from some of these FRB candidates. As all these signals were detected in the 20 cm band, the UWL provides the opportunity to observe stronger emission in other observing bands.
DOI: 10.6084/m9.figshare.21080476
title: Supporting Data

description: Supporting data for reproducing the figures found in Nature Communication paper "Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment"
DOI: 10.48366/r216269
title: Comparison on Knowledge Graph Construction Surveys

description: This comparison explored different knowledge graph construction surveys to highlight application approaches etc.
DOI: 10.25934/pr00006053.8
title: Available IPD datapackage for study 'A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Atezolizumab (MPDL3280A, Anti-PD-L1 Antibody) in Combination With Carboplatin+Paclitaxel or Atezolizumab in Combination With Carboplatin+Nab-Paclitaxel Versus Carboplatin+Nab-Paclitaxel in Chemotherapy-Naive Patients With Stage IV Squamous Non-Small Cell Lung Cancer'

description: This randomized, open-label study will evaluate the safety and efficacy of atezolizumab (MPDL3280A) in combination with carboplatin + paclitaxel or carboplatin + nab-paclitaxel compared with treatment with carboplatin + nab-paclitaxel in chemotherapy-naive participants with Stage IV squamous NSCLC.