cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19097634
title: Dapagliflozin attenuates cholesterol overloading-induced injury in mice hepatocytes with type 2 diabetes mellitus (T2DM) via eliminating oxidative damages

description: Cholesterol overloading-induced damages on hepatocytes cause liver dysfunctions, which further damages cholesterol metabolism and results in visceral fat accumulation in patients with type 2 diabetes mellitus (T2DM). The sodium-glucose cotransporter 2 (SGLT2) inhibitor Dapagliflozin has been reported to regulate cholesterol levels in T2DM patients, but the underlying mechanisms have not been studied. In the present study, we initially established <i>in vivo</i> T2DM mice models, and our results showed that both free cholesterol (FC) and cholesteryl ester (CE) were accumulated, while the pro-proliferation associated genes were downregulated in T2DM mice liver tissues, which were reversed by Dapagliflozin co-treatment. Similarly, the mice primary hepatocytes were loaded with cholesterol to establish <i>in vitro</i> models, and we expectedly found that Dapagliflozin attenuated cholesterol-overloading induced cytotoxicity and cellular senescence in the hepatocytes. Then, we noticed that oxidative damages occurred in T2DM mice liver tissues and cholesterol treated hepatocytes, which could be suppressed by Dapagliflozin. Also, elimination of Reactive Oxygen Species (ROS) by N-acetyl-L-cysteine (NAC) recovered cellular functions of hepatocytes <i>in vitro</i> and <i>in vivo</i>. Furthermore, the potential underlying mechanisms were uncovered, and our data suggested that Dapagliflozin activated the anti-oxidant Nrf2/HO-1 pathway in mice hepatocytes, and silencing of Nrf2 abrogated the protective effects of Dapagliflozin on cholesterol-overloaded hepatocytes. Collectively, we concluded that Dapagliflozin recovered cholesterol metabolism functions in T2DM mice liver via activating the anti-oxidant Nrf2/HO-1 pathway, and our data supported that Dapagliflozin was a potential therapeutic drug to eliminate cholesterol-induced cytotoxicity during T2DM pathogenesis.
DOI: 10.6084/m9.figshare.23812445
title: Additional file 4 of Genome-wide characterization, evolutionary analysis, and expression pattern analysis of the trihelix transcription factor family and gene expression analysis under MeJA treatment in Panax ginseng

description: Additional file 4: Table S4. The classification, annotation and GO functional categorization of the PgGT gene transcripts.
DOI: 10.6084/m9.figshare.12806080.v1
title: Additional file 8 of Proteomic analysis revealed common, unique and systemic signatures in gender-dependent hepatocarcinogenesis

description: Additional file 8: Table S1. Detailed information for identified and quantified proteins.
DOI: 10.6084/m9.figshare.19097634.v1
title: Dapagliflozin attenuates cholesterol overloading-induced injury in mice hepatocytes with type 2 diabetes mellitus (T2DM) via eliminating oxidative damages

description: Cholesterol overloading-induced damages on hepatocytes cause liver dysfunctions, which further damages cholesterol metabolism and results in visceral fat accumulation in patients with type 2 diabetes mellitus (T2DM). The sodium-glucose cotransporter 2 (SGLT2) inhibitor Dapagliflozin has been reported to regulate cholesterol levels in T2DM patients, but the underlying mechanisms have not been studied. In the present study, we initially established <i>in vivo</i> T2DM mice models, and our results showed that both free cholesterol (FC) and cholesteryl ester (CE) were accumulated, while the pro-proliferation associated genes were downregulated in T2DM mice liver tissues, which were reversed by Dapagliflozin co-treatment. Similarly, the mice primary hepatocytes were loaded with cholesterol to establish <i>in vitro</i> models, and we expectedly found that Dapagliflozin attenuated cholesterol-overloading induced cytotoxicity and cellular senescence in the hepatocytes. Then, we noticed that oxidative damages occurred in T2DM mice liver tissues and cholesterol treated hepatocytes, which could be suppressed by Dapagliflozin. Also, elimination of Reactive Oxygen Species (ROS) by N-acetyl-L-cysteine (NAC) recovered cellular functions of hepatocytes <i>in vitro</i> and <i>in vivo</i>. Furthermore, the potential underlying mechanisms were uncovered, and our data suggested that Dapagliflozin activated the anti-oxidant Nrf2/HO-1 pathway in mice hepatocytes, and silencing of Nrf2 abrogated the protective effects of Dapagliflozin on cholesterol-overloaded hepatocytes. Collectively, we concluded that Dapagliflozin recovered cholesterol metabolism functions in T2DM mice liver via activating the anti-oxidant Nrf2/HO-1 pathway, and our data supported that Dapagliflozin was a potential therapeutic drug to eliminate cholesterol-induced cytotoxicity during T2DM pathogenesis.
DOI: 10.6084/m9.figshare.12806083.v1
title: Additional file 9 of Proteomic analysis revealed common, unique and systemic signatures in gender-dependent hepatocarcinogenesis

description: Additional file 9: Table S2. Detailed information of identified DEPs validated by Western Blot assays.
DOI: 10.5281/zenodo.7275803
title: Data used in "Climatology and variability of air mass transport from the boundary layer to the Asian monsoon anticyclone"

description: The data presented here are needed to reproduce the analyses of the publication: Nützel, M., Brinkop, S., Dameris, M., Garny, H., Jöckel, P., Pan, L. L., and Park, M.: Climatology and variability of air mass transport from the boundary layer to the Asian monsoon anticyclone, Atmos. Chem. Phys., 22, 15659–15683, https://doi.org/10.5194/acp-22-15659-2022, 2022. A short explanation of the archived data is presented in the accompanying README.


Note: In the previous data set version (10.5281/zenodo.7275804) one file was missing and is added here.
DOI: 10.5281/zenodo.7275804
title: Data used in "Climatology and variability of air mass transport from the boundary layer to the Asian monsoon anticyclone"

description: The data presented here are needed to reproduce the analyses of the publication: Nützel, M., Brinkop, S., Dameris, M., Garny, H., Jöckel, P., Pan, L. L., and Park, M.: Climatology and variability of air mass transport from the boundary layer to the Asian monsoon anticyclone, Atmos. Chem. Phys., 22, 15659–15683, https://doi.org/10.5194/acp-22-15659-2022, 2022. A short explanation of the archived data is presented in the accompanying README.
description: {"references": ["N\u00fctzel et al., 2021, ACP, \"\""]}
DOI: 10.5281/zenodo.7438872
title: Data used in "Climatology and variability of air mass transport from the boundary layer to the Asian monsoon anticyclone"

description: The data presented here are needed to reproduce the analyses of the publication: Nützel, M., Brinkop, S., Dameris, M., Garny, H., Jöckel, P., Pan, L. L., and Park, M.: Climatology and variability of air mass transport from the boundary layer to the Asian monsoon anticyclone, Atmos. Chem. Phys., 22, 15659–15683, https://doi.org/10.5194/acp-22-15659-2022, 2022. A short explanation of the archived data is presented in the accompanying README.


Note: In the previous data set version (10.5281/zenodo.7275804) one file was missing and is added here.
DOI: 10.6084/m9.figshare.8087687
title: Additional file 1: of Enhancing the one health initiative by using whole genome sequencing to monitor antimicrobial resistance of animal pathogens: Vet-LIRN collaborative project with veterinary diagnostic laboratories in United States and Canada

description: Metadata entry template sheet. (XLSX 284 kb)
DOI: 10.6084/m9.figshare.8087750
title: MOESM7 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 7. KEGG pathway analysis of two libraries.
DOI: 10.5281/zenodo.10656763
title: Evolution of thermal and mechanical properties of commercial biodegradable blends subjected to mechanical recycling
DOI: 10.5281/zenodo.10656764
title: Evolution of thermal and mechanical properties of commercial biodegradable blends subjected to mechanical recycling
DOI: 10.6084/m9.figshare.8087750.v1
title: MOESM7 of Comparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq

description: Additional file 7. KEGG pathway analysis of two libraries.
DOI: 10.6084/m9.figshare.7045574
title: Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation

description: Hypertensive renal damage generally occurs during the middle and late stages of hypertension, which is typically characterized by proteinuria and renal inflammation. Captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been widely used for therapy of arterial hypertension and cardiovascular diseases. However, the protective effects of captopril on hypertension-induced organ damage remain elusive. The present study was designed to explore the renoprotective action of captopril in spontaneously hypertensive rats (SHR). The 6-week-old male SHR and age-matched Wistar-Kyoto rats were randomized into long-term captopril-treated (34 mg/kg) and vehicle-treated groups. The results showed that in SHR there was obvious renal injury characterized by the increased levels of urine albumin, total protein, serum creatinine, blood urea nitrogen, renal inflammation manifested by the increased mRNA and protein expression of inflammatory factors including tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and inducible nitric oxide synthase, and enhanced nuclear factor-κB (NF-κB) activation. Captopril treatment could lower blood pressure, improve renal injury, and suppress renal inflammation and NF-κB activation in SHR rats. In conclusion, captopril ameliorates renal injury and inflammation in SHR possibly via inactivation of NF-κB signaling.
DOI: 10.6084/m9.figshare.13337048
title: Assessing the interaction between Chinese sturgeon and wake behind D-shaped cylinder

description: This data deposit contains all the datasets needed to draw Figures (4,6) in the paper "Assessing the interaction between Chinese sturgeon and wake behind D-shaped cylinder", which is now under consideration for publication in Water Resources Research
DOI: 10.6084/m9.figshare.24347102
title: Efficient Model-Free Subsampling Method for Massive Data

description: Subsampling plays a crucial role in tackling problems associated with the storage and statistical learning of massive datasets. However, most existing subsampling methods are model-based, which means their performances can drop significantly when the underlying model is misspecified. Such an issue calls for model-free subsampling methods that are robust under diverse model specifications. Recently, several model-free subsampling methods have been developed. However, the computing time of these methods grows explosively with the sample size, making them impractical for handling massive data. In this article, an efficient model-free subsampling method is proposed, which segments the original data into some regular data blocks and obtains subsamples from each data block by the data-driven subsampling method. Compared with existing model-free subsampling methods, the proposed method has a significant speed advantage and performs more robustly for datasets with complex underlying distributions. As demonstrated in simulation experiments, the proposed method is an order of magnitude faster than other commonly used model-free subsampling methods when the sample size of the original dataset reaches the order of 10<sup>7</sup>. Moreover, simulation experiments and case studies show that the proposed method is more robust than other model-free subsampling methods under diverse model specifications and subsample sizes.
DOI: 10.6084/m9.figshare.12288485
title: Acute kidney injury after nephron sparing surgery and microwave ablation: focus on incidence, survival impact and prediction

description: To compare acute kidney injury (AKI) incidence between nephron sparing surgery (NSS) and microwave ablation (MWA) for T1a RCC patients, reveal the effect of AKI on survival prognosis, construct AKI nomogram and use Law of Total Probability for survival probability (SP) prediction. Patients were studied retrospectively after NSS (<i>n</i> = 1267) or MWA (<i>n</i> = 210) from January 1, 2011 to June 30, 2017. Using one to one Propensity Score Matching (PSM), 158 pairs of patients were identified for the cohort study. AKI incidence, risk factors and impact on survival outcomes were analyzed using Chi-square test, logistic and cox regression analysis. AKI risk and SP were predicted by nomogram and Law of Total Probability. The performance of the nomogram was assessed with respect to its discrimination, calibration, and clinical usefulness. AKI occurred more commonly in NSS (27.85%) cohort, when compared to MWA (17.72%) cohort (<i>p</i> = 0.032), but treatment modality was not independently predictive of AKI occurrence (odds ratio [OR]: 0.598; 95% confidence interval [CI]: 0.282–1.265; <i>p</i> = 0.178). The 5-yr overall survival (OS) was lower in AKI patients (73.5%) compared with non-AKI patients (94.8%; <i>p</i> &lt; 0.001). AKI was an independent risk factor for all-cause mortality in RCC patients (hazard ratio [HR]: 2.820; 95% confidence interval [CI]: 1.110–7.165; <i>p</i> = 0.029). Predictors for both NSS- and MWA-related AKI included tumor diameter, baseline eGFR and CCI score. RENAL score and tumor blood supply can predict AKI after NSS and MWA, respectively. The AKI normograms demonstrated good discrimination, with AUCs &gt;0.86, excellent calibration and net benefits at the decision curve analysis with probabilities ≥5%. SP predicted by Law of Total Probability was comparable to actual OS. AKI was an early indicator for poor overall survival in RCC patients. It can be predicted by several oncological parameters. Nomogram and Law of Total Probability can accurately predict AKI risk and SP.
DOI: 10.6084/m9.figshare.14379165.v1
title: Additional file 3 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 3. Jaccard Index of prognostic-hallmark gene groups. Jaccard index score of the set of prognostic-hallmark genes annotated to the same cancer groups when applying paired mapping schemes.
DOI: 10.6084/m9.figshare.14379180.v1
title: Additional file 8 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 8. Correspondence between MSigDB pathways and GO terms. GO terms corresponding to MSigDB pathways were extracted directly from MSigDB.
DOI: 10.6084/m9.figshare.14379180
title: Additional file 8 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 8. Correspondence between MSigDB pathways and GO terms. GO terms corresponding to MSigDB pathways were extracted directly from MSigDB.
DOI: 10.6084/m9.figshare.14379153.v1
title: Additional file 12 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 12. List of hallmark genes. Hallmark genes of GO mapping methods were generated by finding genes annotated to GO term selected by each method. The GO data and gene annotation was downloaded in Jan 2021. The full list of genes annotated to pathways was provided in the literature’s supplementary files.
DOI: 10.6084/m9.figshare.14379165
title: Additional file 3 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 3. Jaccard Index of prognostic-hallmark gene groups. Jaccard index score of the set of prognostic-hallmark genes annotated to the same cancer groups when applying paired mapping schemes.
DOI: 10.6084/m9.figshare.14379150.v1
title: Additional file 11 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 11. Full list of GO terms collected from papers. GO1, GO2, GO3 and GO4 represent 4 GO mapping schemes collected from 3 papers and 1 poster. Every page shows an individual cancer hallmark and GO terms which were assigned to it by different methods.
DOI: 10.6084/m9.figshare.14379183.v1
title: Additional file 9 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 9. Consensus among all mapping schemes. GO terms selected by more than 2 schemes (without PW1)/3 (with PW1) are considered as consensus terms.
DOI: 10.6084/m9.figshare.14379156.v1
title: Additional file 13 of Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations

description: Additional file 13. Prognostic genes of 17 cancer types.
DOI: 10.15468/dl.8pjqj3
title: Occurrence Download

description: A dataset containing 130 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pouzolzia denudata De Wild. & T.Durand"
 ]
}

 The dataset includes 130 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080941-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9hxaa3
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "GenusKey" : [
 "is Afzelia J.F.Gmel., 1792"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080942-240321170329656/datasets/export for details.
DOI: 10.15468/dl.g4q9s7
title: Occurrence Download

description: A dataset containing 5240 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Protea cynaroides (L.) L."
 ]
}

 The dataset includes 5240 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080943-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m9req8
title: Occurrence Download

description: A dataset containing 97 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polystichum drepanum (Sw.) C.Presl"
 ]
}

 The dataset includes 97 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080944-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wx9n2s
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pouzolzia fadenii Friis & Jellis"
 ]
}

 The dataset includes 24 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080945-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w59cn4
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "GenusKey" : [
 "is Incertae sedis"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080946-240321170329656/datasets/export for details.
DOI: 10.15468/dl.e7jwnm
title: Occurrence Download

description: A dataset containing 62 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polystichum duthiei (C.Hope) C.Chr."
 ]
}

 The dataset includes 62 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080947-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pmb2k8
title: Occurrence Download

description: A dataset containing 82 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Protea decurrens E.Phillips"
 ]
}

 The dataset includes 82 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080948-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kgn3f3
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "GenusKey" : [
 "is Afzelia Robineau-Desvoidy, 1863"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080950-240321170329656/datasets/export for details.
DOI: 10.15468/dl.thkc76
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pouzolzia floresiana Friis & Wilmot-Dear"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080949-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.22gcdx
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polystichum elmeri Copel."
 ]
}

 The dataset includes 12 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080951-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pscp5h
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Protea dekindtiana Engl."
 ]
}

 The dataset includes 7 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080952-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rwn4yc
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "GenusKey" : [
 "is Afzelia Robineau-Desvoidy, 1863"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080953-240321170329656/datasets/export for details.
DOI: 10.15468/dl.xrwrgn
title: Occurrence Download

description: A dataset containing 46 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pouzolzia gaudichaudii Leandri"
 ]
}

 The dataset includes 46 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080954-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.459uu7
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Polystichum eriorachis Alderw."
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080955-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6tzfcy
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "GenusKey" : [
 "is Afzelia Sm."
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0080956-240321170329656/datasets/export for details.