cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11323454
title: Supplementary Material for: Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

description: Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In humans, the paired sialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have reciprocal roles in regulating macrophage immune responses, but their interaction with IL-1β signaling and the inflammasome has not been characterized. Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B <i>Streptococcus</i> (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1β release. Human THP-1 macrophages stably transfected with Siglec-14 exhibited increased caspase-1 activation, IL-1β release and pyroptosis after GBS infection, in a manner blocked by a specific inhibitor of nucleotide-binding domain leucine-rich repeat protein 3 (NLRP3), a protein involved in inflammasome assembly. Another leading pathogen, <i>Streptococcus pneumoniae</i>, lacks sialic acid but rather prominently expresses a sialidase, which cleaves sialic acid from macrophages, eliminating <i>cis</i>- interactions with the lectin receptor, thus attenuating Siglec-14 induced IL-1β secretion. Vimentin, a cytoskeletal protein released during macrophage inflammatory activation is known to induce the inflammasome. We found that vimentin has increased interaction with Siglec-14 compared to Siglec-5, and this interaction heightened IL-1β production by Siglec-14-expressing cells. Siglec-14 is absent from some humans because of a <i>SIGLEC5/14</i> fusion polymorphism, and we found increased IL-1β expression in primary macrophages from <i>SIGLEC14</i><sup>+/+</sup> individuals compared to those with the <i>SIGLEC14</i><sup>–/+</sup> and <i>SIGLEC14</i><sup>–/–</sup> genotypes. Collectively, our results identify a new immunoregulatory role of Siglec-14 as a positive regulator of NLRP3 inflammasome activation.
DOI: 10.6084/m9.figshare.11323457
title: Microbial binning of Almeida et al dataset using VAMB - Abundance Matrix

description: Abundance matrix of all clusters with at least one near complete genome (NC) from Almeida et al benchmark dataset that was binned using VAMB. <br>Abundance of each cluster was determined from jgi_summarize_bam_contig_depths based on the alignments. The weighted average was determined for each bin in a cluster weighting the read abundance with contig lengths. Hereafter, the abundance of the clusters was determined as the sum of each bin in the particular cluster. <br>
DOI: 10.6084/m9.figshare.11323418
title: Microbial binning of Almeida et al dataset using VAMB, p2

description: Part two of VAMB binning on Almeida et al benchmark dataset<br>
DOI: 10.6084/m9.figshare.11323415
title: Microbial binning of Almeida et al dataset using VAMB, p3

description: Part three of VAMB binning on Almeida et al benchmark dataset<br>
DOI: 10.6084/m9.figshare.11323457.v1
title: Microbial binning of Almeida et al dataset using VAMB - Abundance Matrix

description: Abundance matrix of all clusters with at least one near complete genome (NC) from Almeida et al benchmark dataset that was binned using VAMB. <br>Abundance of each cluster was determined from jgi_summarize_bam_contig_depths based on the alignments. The weighted average was determined for each bin in a cluster weighting the read abundance with contig lengths. Hereafter, the abundance of the clusters was determined as the sum of each bin in the particular cluster. <br>
DOI: 10.6084/m9.figshare.11323415.v1
title: Microbial binning of Almeida et al dataset using VAMB, p3

description: Part three of VAMB binning on Almeida et al benchmark dataset<br>
DOI: 10.6084/m9.figshare.11323418.v1
title: Microbial binning of Almeida et al dataset using VAMB, p2

description: Part two of VAMB binning on Almeida et al benchmark dataset<br>
DOI: 10.6084/m9.figshare.12848432
title: The evaluation of feeding, mortality and oviposition of poultry red mite (Dermanyssus gallinae) on aging hens using a high welfare on-hen feeding device_DATA.xlsx

description: A data set across time showing feeding rates, mortality and fecundity when using a high welfare feeding device.
DOI: 10.6084/m9.figshare.11323361
title: Microbial binning of Almeida et al dataset using VAMB, p1

description: File 1 of 4 of the metagenomic binning of Almeida et al. 2019 benchmark dataset done using VAMB.<br>
DOI: 10.6084/m9.figshare.11323337
title: 13C and 15N pulse labeling data from greenhouse experiment

description: Dataset for Keller and Philips 2019. Frontiers in Forest and Global Change. Relationship between belowground carbon allocation and nitrogen uptake in saplings varies by plant mycorrhizal type.
DOI: 10.6084/m9.figshare.11323361.v1
title: Microbial binning of Almeida et al dataset using VAMB, p1

description: File 1 of 4 of the metagenomic binning of Almeida et al. 2019 benchmark dataset done using VAMB.<br>
DOI: 10.6084/m9.figshare.12848432.v1
title: The evaluation of feeding, mortality and oviposition of poultry red mite (Dermanyssus gallinae) on aging hens using a high welfare on-hen feeding device_DATA.xlsx

description: A data set across time showing feeding rates, mortality and fecundity when using a high welfare feeding device.
DOI: 10.6084/m9.figshare.11323337.v1
title: 13C and 15N pulse labeling data from greenhouse experiment

description: Dataset for Keller and Philips 2019. Frontiers in Forest and Global Change. Relationship between belowground carbon allocation and nitrogen uptake in saplings varies by plant mycorrhizal type.
DOI: 10.6084/m9.figshare.11323289
title: Time-to-target simplifies optimal control of visuomotor feedback responses

description: This is the dataset, analysis and figure scripts for the article entitled "Time-to-target simplifies optimal control of visuomotor feedback responses". We provide the behavioural data (kinematics and forces) for point-to-point reaches to a target, where lateral cursor jumps are introduced during the reach. We also include various OFC models to normatively model our data: finite, infinite and receding horizon models, as well as a time-to-target dependent model
DOI: 10.6084/m9.figshare.11323304
title: Input data for: Global vulnerability of marine mammals to global warming.

description: The data set encompass the taxonomic, functional and phylogenetic data used in the study published in scientific report: Global vulnerability of marine mammals to global warming.<br><br>Phylogenetic tree data comes from Fritz et al 2009. The presence absence matrix was computed based on IUCN data. For more details on the traits data please see Albouy et al (2017).<br> Fritz, S. A., Bininda-Emonds, O. R. P. & Purvis, A. Geographical variation in predictors of mammalian extinction risk: big is bad, but only in the tropics. <i>Ecol. Lett.</i> <b>12</b>, 538–549 (2009). <br> Albouy, C., Delattre, V. L., Mérigot, B., Meynard, C. N. & Leprieur, F. Multifaceted biodiversity hotspots of marine mammals for conservation priorities. <i>Divers. Distrib.</i> <b>23</b>, 615–626 (2017).
DOI: 10.6084/m9.figshare.11323259
title: Sequence data for DENV

description: Sequence data for DENV
DOI: 10.6084/m9.figshare.11323259.v1
title: Data Citation 10

description: Seqeunce data of DENV
DOI: 10.6084/m9.figshare.11323259.v2
title: Seqeunce data of DENV

description: Seqeunce data of DENV
DOI: 10.6084/m9.figshare.11323214
title: Normalized titer for DENV

description: normalized titer for DENV
DOI: 10.6084/m9.figshare.11323214.v1
title: Data Citation 9

description: normalized titer for DENV
DOI: 10.6084/m9.figshare.11323151
title: HA sequence data for IBV

description: HA sequence data for IBV
DOI: 10.6084/m9.figshare.11323121
title: Pair-wise antigenic distance for IBV

description: pair-wise antigenic distance for IBV
DOI: 10.6084/m9.figshare.11323109
title: Data Citation 7

description: pair-wised antigneic distance for IVB
DOI: 10.6084/m9.figshare.11323109.v1
title: Data Citation 7

description: pair-wised antigneic distance for IVB
DOI: 10.6084/m9.figshare.11323100
title: Supplementary Material for: Prevalence and Impact of Type I Sensitization to Alpha-Gal in Patients Consulting an Allergy Unit

description: <b><i>Background:</i></b> Alpha-gal syndrome is a complex allergy with high clinical relevance regarding mammalian-derived food and drugs and is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-α-1,3-galactose. As not all alpha-gal sIgE-positive individuals pre­sent clinical symptoms upon consumption of mammalian meat, the diagnostic value of alpha-gal sIgE has yet to be clarified. <b><i>Objective:</i></b> To investigate the prevalence of alpha-gal-sIgE positivity among allergy patients, examine the impact of tick bites as associated risk factors and determine the diagnostic value of alpha-gal-sIgE positivity. <b><i>Methods:</i></b> A retrospective cross-sectional study evaluating patients in the Allergy Unit was performed. Alpha-gal-sIgE levels were assessed by ImmunoCAP assay. Exposure to tick bites was assessed by a questionnaire. A receiver operating characteristics (ROC) curve analysis was performed to determine the diagnostic value of alpha-gal sIgE for the diagnosis of alpha-gal syndrome. <b><i>Results:</i></b> In the study population (<i>n</i> = 1369), the overall prevalence of alpha-gal-sIgE-positive (≥0.10 kU<sub>A</sub>/L) individuals was 19.9%, and the highest prevalence (30.2%) was found in patients with insect venom allergies. A reported tick bite within the 12 months prior to blood sampling significantly increased the risk of alpha-gal-sIgE positivity (OR 2.084). The ROC curve analysis indicated alpha-gal sIgE ≥0.54 kU<sub>A</sub>/L as the optimal cutoff point for assessing the diagnostic value of alpha-gal syndrome in allergy patients. <b><i>Conclusions:</i></b> In allergy care settings, alpha-gal-sIgE positivity is a common finding. Alpha-gal sIgE is a sensitive marker in the diagnosis of alpha-gal syndrome but has limited predictive value for the characteristics or severity of this allergy.
DOI: 10.6084/m9.figshare.11323151.v2
title: HA sequence data for IBV

description: HA sequence data for IBV
DOI: 10.6084/m9.figshare.11323058
title: Exposure to phthalates and cardiovascular diseases with type 2 diabetes

description: supplemental data to the manuscript "Exposure to phthalates and cardiovascular diseases with type 2 diabetes"
DOI: 10.6084/m9.figshare.11323121.v1
title: Data Citation 7

description: pair-wised antigneic distance for IVB
DOI: 10.6084/m9.figshare.11323058.v1
title: Exposure to phthalates and cardiovascular diseases with type 2 diabetes

description: supplemental data to the manuscript "Exposure to phthalates and cardiovascular diseases with type 2 diabetes"
DOI: 10.6084/m9.figshare.11323151.v1
title: Data Citation 8

description: HA sequence data for IVB
DOI: 10.6084/m9.figshare.11323121.v2
title: pair-wise antigenic distance for IVB

description: pair-wise antigenic distance for IVB
DOI: 10.6084/m9.figshare.11323121.v3
title: Pair-wise antigenic distance for IVB

description: pair-wise antigenic distance for IVB
DOI: 10.6084/m9.figshare.11323007
title: Data_CI

description: a dataset regarding CI and TC
DOI: 10.6084/m9.figshare.11323001
title: Phylonetworks_input_trees.zip

description: Tree files generated for use in phylonetworks analysis of gene tree incongruence and introgression.
DOI: 10.6084/m9.figshare.11322998
title: Phylonetworks_reduced_taxa_alignments.zip

description: Alignments from assembled phylogenomic read data, from which trees were inferred for phylonetworks analysis of introgression and gene tree discordance.
DOI: 10.6084/m9.figshare.11323001.v1
title: Phylonetworks_input_trees.zip

description: Tree files generated for use in phylonetworks analysis of gene tree incongruence and introgression.
DOI: 10.6084/m9.figshare.11323007.v1
title: Data_CI

description: a dataset regarding CI and TC
DOI: 10.6084/m9.figshare.11322992
title: BGC_INPUT.zip

description: Input files for bgc, a program which allows the estimation of various parameters relating to hybridization for many loci from a population genomic dataset.
DOI: 10.6084/m9.figshare.11322995
title: Stacks_output.zip

description: Output from the Stacks (Catchen et al) pipeline for identifying variants from ddRADseq data
DOI: 10.6084/m9.figshare.11322998.v1
title: Phylonetworks_reduced_taxa_alignments.zip

description: Alignments from assembled phylogenomic read data, from which trees were inferred for phylonetworks analysis of introgression and gene tree discordance.
DOI: 10.6084/m9.figshare.11322986
title: DATASET-DISSERTAÇÃO-MINERAÇÃO DE DADOS ABERTOS-UMA ANÁLISE DO USO DE BOTS EM PREGÕES ELETRÔNICOS

description: DataSet for use in RapidMiner from the master's thesis. <br>OPEN DATA MINING: AN ANALYSIS OF THE USE OF BOTS IN THE<br>ELECTRONIC TRADING FLOORS<br>Dissertation presented to the Graduate Program in Management in Learning Organizations in compliance with the requirements for completion of the Professional Master in Management in Learning Organizations-UFPB.<br>Brazil's federal government has sought to match procurement procedures to trends in information and communication technologies. The electronic reverse auction was one of the products of these efforts, being characterized as a modality that presented structural solutions to improve the efficiency of purchases of common goods and services and that represents more than 94% of the bids that occurred in the country. Despite the benefits of electronic format, this environment brings challenges, such as dealing with the use of bots, which works by automatically bidding. While there is no law prohibiting its use, judgments of the Federal Court of Auditors state that its use provides a competitive advantage to suppliers holding this technology in question over other bidders, characterizing an affront to the principle of isonomy. Also in the sense of modernizing public procurement is increasing transparency through open data policies, as part of the context of Open Government and digital transformation. This study aims to analyze the situation of bot use in electronic reverse auctions through open data mining. Electronic reverse auctions held at the Ministry of Agriculture, Livestock and Supply in 2017 were analyzed. Data were obtained by request by the Electronic Information System for Citizen Information (e-SIC), having been adopted as methodology the knowledge discovery in databases. The results indicate that bot use in electronic reverse auctions in 2017 represented a more than 5% advantage in successful bid items observed for only 1.99% of the sample bidders, indicated as suspected use. The most relevant indicator for classifying bidders as suspects was the high number of bids issued in relation to the behavior observed in the sample. Results are expected to foster discussion of the effects of bot use on e-trading and to highlight the need for open data policy development for data mining to be an increasingly effective means to assess anomalies and increase the integrity of the bids made by the Federal Government Procurement Portal.<br>DataSet para uso no RapidMiner provenientes da dissertação de mestrado. MINERAÇÃO DE DADOS ABERTOS: UMA ANÁLISE DO USO DE BOTS EMPREGÕES ELETRÔNICOSDissertação apresentada ao Programa de Pós-Graduação em Gestão nas Organizações Aprendentes em cumprimento às exigências para conclusão do Mestrado Profissional em Gestão nas Organizações Aprendentes-UFPB.https://sig-arq.ufpb.br/arquivos/2019071230f6981803056bc243c9a4b41/Dissertao_-_Hugo_Medeiros_Souto_-_Minerao_de_Dados_Abertos_2.pdf<br>
DOI: 10.6084/m9.figshare.11322989
title: Detarioideae_bait_v1.fasta

description: Bait files for assembly of phylogenomic read data using HybPiper, published by Ojedo et al 2019.
DOI: 10.6084/m9.figshare.11322992.v1
title: BGC_INPUT.zip

description: Input files for bgc, a program which allows the estimation of various parameters relating to hybridization for many loci from a population genomic dataset.
DOI: 10.6084/m9.figshare.11322995.v1
title: Stacks_output.zip

description: Output from the Stacks (Catchen et al) pipeline for identifying variants from ddRADseq data
DOI: 10.6084/m9.figshare.11322986.v1
title: DATASET-DISSERTAÇÃO-MINERAÇÃO DE DADOS ABERTOS-UMA ANÁLISE DO USO DE BOTS EM PREGÕES ELETRÔNICOS

description: DataSet for use in RapidMiner from the master's thesis. <br>OPEN DATA MINING: AN ANALYSIS OF THE USE OF BOTS IN THE<br>ELECTRONIC TRADING FLOORS<br>Dissertation presented to the Graduate Program in Management in Learning Organizations in compliance with the requirements for completion of the Professional Master in Management in Learning Organizations-UFPB.<br>Brazil's federal government has sought to match procurement procedures to trends in information and communication technologies. The electronic reverse auction was one of the products of these efforts, being characterized as a modality that presented structural solutions to improve the efficiency of purchases of common goods and services and that represents more than 94% of the bids that occurred in the country. Despite the benefits of electronic format, this environment brings challenges, such as dealing with the use of bots, which works by automatically bidding. While there is no law prohibiting its use, judgments of the Federal Court of Auditors state that its use provides a competitive advantage to suppliers holding this technology in question over other bidders, characterizing an affront to the principle of isonomy. Also in the sense of modernizing public procurement is increasing transparency through open data policies, as part of the context of Open Government and digital transformation. This study aims to analyze the situation of bot use in electronic reverse auctions through open data mining. Electronic reverse auctions held at the Ministry of Agriculture, Livestock and Supply in 2017 were analyzed. Data were obtained by request by the Electronic Information System for Citizen Information (e-SIC), having been adopted as methodology the knowledge discovery in databases. The results indicate that bot use in electronic reverse auctions in 2017 represented a more than 5% advantage in successful bid items observed for only 1.99% of the sample bidders, indicated as suspected use. The most relevant indicator for classifying bidders as suspects was the high number of bids issued in relation to the behavior observed in the sample. Results are expected to foster discussion of the effects of bot use on e-trading and to highlight the need for open data policy development for data mining to be an increasingly effective means to assess anomalies and increase the integrity of the bids made by the Federal Government Procurement Portal.<br>DataSet para uso no RapidMiner provenientes da dissertação de mestrado. MINERAÇÃO DE DADOS ABERTOS: UMA ANÁLISE DO USO DE BOTS EMPREGÕES ELETRÔNICOSDissertação apresentada ao Programa de Pós-Graduação em Gestão nas Organizações Aprendentes em cumprimento às exigências para conclusão do Mestrado Profissional em Gestão nas Organizações Aprendentes-UFPB.https://sig-arq.ufpb.br/arquivos/2019071230f6981803056bc243c9a4b41/Dissertao_-_Hugo_Medeiros_Souto_-_Minerao_de_Dados_Abertos_2.pdf<br>
DOI: 10.6084/m9.figshare.11322989.v1
title: Detarioideae_bait_v1.fasta

description: Bait files for assembly of phylogenomic read data using HybPiper, published by Ojedo et al 2019.
DOI: 10.6084/m9.figshare.11322863
title: dati_mensili.txt

description: Time series 1951-2018 of monthly precipitation data of 15 stations of Abruzzo region, central Italy. Data provided from the Italian National Hydrographic Service.
DOI: 10.6084/m9.figshare.11322863.v1
title: dati_mensili.txt

description: Time series 1951-2018 of monthly precipitation data of 15 stations of Abruzzo region, central Italy. Data provided from the Italian National Hydrographic Service.
DOI: 10.6084/m9.figshare.11322116
title: LGF clustering for genes located in cps/kps loci

description: Two tables linking protein sequences found in cps and kps loci (one table each) with the locus gene families (LGFs) into which these proteins were assigned.
DOI: 10.6084/m9.figshare.11322842.v1
title: Unraveling the genetic diversity of Belgian Milk Sheep using medium density SNP genotypes: SNP genotypes

description: Title: Unraveling the genetic diversity of Belgian Milk Sheep using medium density SNP genotypesJournal: Animal Genetics <br>Article DOI: 10.1111/age.12891<br>
DOI: 10.6084/m9.figshare.11322101
title: Fig. 5

description: Fig.5. Dual stimuli effect on cell differentiation.<br>
DOI: 10.6084/m9.figshare.11322119.v1
title: Databases for Upper Palaeolithic in the Cserhát Mts.

description: This database serves to my PhD project, Upper Palaeolithic in the Cserhát Mts., Hungary. Description in Hungarian:<br>Az ELTE Történelemtudományok doktori iskola régészeti programjának kereti között végzett kutatásomban a Kárpát-medence legkorábbi, 40-20 ezer évvel ezelőtti Homo sapiens közösségeinek életmódjával foglalkozom. E hosszú időszak alatt jelentős klímaingadozások zajlottak, a kor emberei pedig különféle kulturális stratégiákat alakítottak ki a változó környezeti viszonyok kiaknázására. Tájhasználatuk kulcsfontosságú eleme a mobilitás volt, a vadakat követő évszakos mozgástól az egész kontinensre kiterjedő vándorlásokig. Hazánk területe, akárcsak ma, akkor is az Európa és Ázsia közti népességmozgások fontos állomása lehetett.<br>A kutatás a Cserhát-hegység középső és déli részének nagyrészt felszíni, többségében közöletlen, felső paleolitikus korú lelőhelyeit érinti. Célja, hogy ezeket egy olyan modellbe foglalja, ami a pattintott kő leletek készítésének, használatának és elhagyásának mozzanatait helyezi el a térben. A modell segítségével a leletanyagot létrehozó emberek tájhasználati stratégiáit rekonstruálom, illetve a Cserhát szerepét értékelem majd Közép-Európa mobilitási mintázataiban, az Aurignacien és a Gravettien régészeti horizontok idején.
DOI: 10.6084/m9.figshare.11322098
title: Fig. 4

description: Fig.4. Epigenetic alternation of cells exposed to dual stimuli.
DOI: 10.6084/m9.figshare.11322101.v1
title: Fig. 5

description: Fig.5. Dual stimuli effect on cell differentiation.<br>
DOI: 10.6084/m9.figshare.11322098.v1
title: Fig. 4

description: Fig.4. Epigenetic alternation of cells exposed to dual stimuli.