cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21907612
title: Determination of ATP and its metabolites in dietary energy supplements by capillary electrophoresis

description: Abstract This study aimed to develop a simple and fast capillary electrophoresis (CE) method for the simultaneous determination of adenosine triphosphate (ATP) and its metabolites in dietary energy supplements. Reverse polarity separation mode for faster separation of the three strong negatively charged analytes and capillaries with a 25 µm inner diameter was employed. At -433 V/cm field strength at background electrolyte (BGE) consist with 0.1 M tris-HCl, 0.5 mM tetradecyltrimethylammonium chloride (TTAC) as positively charged surfactant and 0.3 mg/mL hydroxypropylmethylcellulose (HPMC) to reduce the electroosmotic flow (EOF), a complete separation of the three species were achieved in less than 15 minutes. The data acquisition was conducted at a wavelength of 254 nm. Three different commercialised dietary energy supplements were analysed.
DOI: 10.6084/m9.figshare.21907612.v1
title: Determination of ATP and its metabolites in dietary energy supplements by capillary electrophoresis

description: Abstract This study aimed to develop a simple and fast capillary electrophoresis (CE) method for the simultaneous determination of adenosine triphosphate (ATP) and its metabolites in dietary energy supplements. Reverse polarity separation mode for faster separation of the three strong negatively charged analytes and capillaries with a 25 µm inner diameter was employed. At -433 V/cm field strength at background electrolyte (BGE) consist with 0.1 M tris-HCl, 0.5 mM tetradecyltrimethylammonium chloride (TTAC) as positively charged surfactant and 0.3 mg/mL hydroxypropylmethylcellulose (HPMC) to reduce the electroosmotic flow (EOF), a complete separation of the three species were achieved in less than 15 minutes. The data acquisition was conducted at a wavelength of 254 nm. Three different commercialised dietary energy supplements were analysed.
DOI: 10.6084/m9.figshare.21907615
title: Vestibular function assessment in sudden hearing loss

description: Abstract Objectives: To perform vestibular assessment using cervical and ocular vestibular evoked myogenic potential, video head impulse test and caloric testing in patients with sudden hearing loss. Moreover, to evaluate the correlation of dizziness with vestibular tests and the correlation of vestibular tests with hearing prognosis. Methods: This is an observational, longitudinal and prospective study, including participants diagnosed with sudden hearing loss. The participants underwent cervical and ocular vestibular evoked myogenic potential, video head impulse test and caloric testing. The audiometric assessment was performed at the beginning and at the end of the follow-up. A value of p ≤ 0.05 was considered statistically significant. Results: Seventeen patients were included in the study sample, with a mean age of 45.4 ± 11.1 years. Five participants (29.41%) had dizziness and 15 (88.23%) had tinnitus. All participants underwent vestibular evaluation through cervical and ocular vestibular evoked myogenic potential and video head impulse test, and 13 of them were evaluated through caloric testing. The cervical vestibular evoked myogenic potential was considered altered in five (29.41%) participants, while 11 (64.71%) showed alterations at the ocular vestibular evoked myogenic potential. The video head impulse test and the caloric testing were considered altered in seven (41.18%) and five (38.46%) participants, respectively. There was no statistically significant correlation between the clinical data and the results of vestibular tests or hearing recovery, nor between the results of vestibular tests and hearing recovery. Conclusion: The assessment through vestibular evoked myogenic potential, video head impulse test and caloric testing showed vestibular involvement in some participants. However, it cannot be stated that the results of the vestibular tests are related to the hearing prognosis of sudden hearing loss.
DOI: 10.6084/m9.figshare.21907615.v1
title: Vestibular function assessment in sudden hearing loss

description: Abstract Objectives: To perform vestibular assessment using cervical and ocular vestibular evoked myogenic potential, video head impulse test and caloric testing in patients with sudden hearing loss. Moreover, to evaluate the correlation of dizziness with vestibular tests and the correlation of vestibular tests with hearing prognosis. Methods: This is an observational, longitudinal and prospective study, including participants diagnosed with sudden hearing loss. The participants underwent cervical and ocular vestibular evoked myogenic potential, video head impulse test and caloric testing. The audiometric assessment was performed at the beginning and at the end of the follow-up. A value of p ≤ 0.05 was considered statistically significant. Results: Seventeen patients were included in the study sample, with a mean age of 45.4 ± 11.1 years. Five participants (29.41%) had dizziness and 15 (88.23%) had tinnitus. All participants underwent vestibular evaluation through cervical and ocular vestibular evoked myogenic potential and video head impulse test, and 13 of them were evaluated through caloric testing. The cervical vestibular evoked myogenic potential was considered altered in five (29.41%) participants, while 11 (64.71%) showed alterations at the ocular vestibular evoked myogenic potential. The video head impulse test and the caloric testing were considered altered in seven (41.18%) and five (38.46%) participants, respectively. There was no statistically significant correlation between the clinical data and the results of vestibular tests or hearing recovery, nor between the results of vestibular tests and hearing recovery. Conclusion: The assessment through vestibular evoked myogenic potential, video head impulse test and caloric testing showed vestibular involvement in some participants. However, it cannot be stated that the results of the vestibular tests are related to the hearing prognosis of sudden hearing loss.
DOI: 10.6084/m9.figshare.21907617
title: Development and characterization of PLGA-Bupivacaine and PLGA-S75:R25 Bupivacaine (Novabupi®) biodegradable implants for postoperative pain

description: Abstract In the hospital environment, postoperative pain is a common occurrence that impairs patient recovery and rehabilitation and lengthens hospitalization time. Racemic bupivacaine hydrochloride (CBV) and Novabupi® (NBV) (S (-) 75% R (+) 25% bupivacaine hydrochloride) are two examples of local anesthetics used in pain management, the latter being an alternative with less deleterious effects. In the present study, biodegradable implants were developed using Poly(L-lactide-co-glycolide) through a hot molding technique, evaluating their physicochemical properties and their in vitro drug release. Different proportions of drugs and polymer were tested, and the proportion of 25%:75% was the most stable for molding the implants. Thermal and spectrometric analyses were performed, and they revealed no unwanted chemical interactions between drugs and polymer. They also confirmed that heating and freeze-drying used for manufacturing did not interfere with stability. The in vitro release results revealed drugs sustained release, reaching 64% for NBV-PLGA and 52% for CBV-PLGA up to 30 days. The drug release mechanism was confirmed by microscopy, which involved pores formation and polymeric erosion, visualized in the first 72 h of the in vitro release test. These findings suggest that the developed implants are interesting alternatives to control postoperative pain efficiently.
DOI: 10.6084/m9.figshare.21907617.v1
title: Development and characterization of PLGA-Bupivacaine and PLGA-S75:R25 Bupivacaine (Novabupi®) biodegradable implants for postoperative pain

description: Abstract In the hospital environment, postoperative pain is a common occurrence that impairs patient recovery and rehabilitation and lengthens hospitalization time. Racemic bupivacaine hydrochloride (CBV) and Novabupi® (NBV) (S (-) 75% R (+) 25% bupivacaine hydrochloride) are two examples of local anesthetics used in pain management, the latter being an alternative with less deleterious effects. In the present study, biodegradable implants were developed using Poly(L-lactide-co-glycolide) through a hot molding technique, evaluating their physicochemical properties and their in vitro drug release. Different proportions of drugs and polymer were tested, and the proportion of 25%:75% was the most stable for molding the implants. Thermal and spectrometric analyses were performed, and they revealed no unwanted chemical interactions between drugs and polymer. They also confirmed that heating and freeze-drying used for manufacturing did not interfere with stability. The in vitro release results revealed drugs sustained release, reaching 64% for NBV-PLGA and 52% for CBV-PLGA up to 30 days. The drug release mechanism was confirmed by microscopy, which involved pores formation and polymeric erosion, visualized in the first 72 h of the in vitro release test. These findings suggest that the developed implants are interesting alternatives to control postoperative pain efficiently.
DOI: 10.6084/m9.figshare.21907623
title: “I WANT to exercise”: the controversial recommendations for physical activity on the Ministry of Health website

description: Abstract The scope of this article is to analyze the contents regarding physical activity posted on the Brazil Health website of the Ministry of Health, between 2017-2020, describing them and discussing the (non-)existent interactions between the contents published and the Physical Education and Public Health area. Through net ethnographic tools, 98 publications that deal with physical activity/physical exercise/corporal practices were located, which were posted on the website over four years. It was observed that the behavioral aspect of health promotion is predominant in all the content, and three perspectives on physical activity recommendations were identified: “sportivized,” daily and generalized physical activity. These approaches are analyzed and considered along with the lack of the predominance of leisure in the recommendations, the absence of coordination with SUS programs and policies, and the lack of clippings that assess the social and economic inequalities in the country that affect the health/disease process and, consequently, the practice of physical activities. In addition to these points, it is essential that communication campaigns to encourage the movement treat the recognition of physical activity as a human right and foster the commitment to a fairer and more equitable society.
DOI: 10.6084/m9.figshare.21907623.v1
title: “I WANT to exercise”: the controversial recommendations for physical activity on the Ministry of Health website

description: Abstract The scope of this article is to analyze the contents regarding physical activity posted on the Brazil Health website of the Ministry of Health, between 2017-2020, describing them and discussing the (non-)existent interactions between the contents published and the Physical Education and Public Health area. Through net ethnographic tools, 98 publications that deal with physical activity/physical exercise/corporal practices were located, which were posted on the website over four years. It was observed that the behavioral aspect of health promotion is predominant in all the content, and three perspectives on physical activity recommendations were identified: “sportivized,” daily and generalized physical activity. These approaches are analyzed and considered along with the lack of the predominance of leisure in the recommendations, the absence of coordination with SUS programs and policies, and the lack of clippings that assess the social and economic inequalities in the country that affect the health/disease process and, consequently, the practice of physical activities. In addition to these points, it is essential that communication campaigns to encourage the movement treat the recognition of physical activity as a human right and foster the commitment to a fairer and more equitable society.
DOI: 10.6084/m9.figshare.21907626
title: Psychosocial aspects related to fruit and vegetable consumption in adolescents

description: Abstract This study aimed at assessing the association between psychosocial aspects and fruit and vegetable consumption in adolescents. Cross-sectional study developed with 327 adolescents from a public school in Brazil. A questionnaire developed for adolescents was applied to assess the influence of self-efficacy, family, peers, and body image on the consumption of fruits and vegetables. Specific questions assessed the intake frequency of fruits and vegetables, and the mean consumption was estimated using two 24-hour recalls. Scores related to psychosocial aspects were described as mean and median and the weight status was classified based on the body mass index. The average daily consumption of fruits and vegetables was 36.2 g and 45.4 g, respectively. Self-efficacy and the influence of peers were associated with an increase in the amount and frequency of fruits and vegetables consumption. Adolescents with higher scores of self-efficacy had greater average consumption of fruits and vegetables when compared to those with lower scores. The same was observed for the influence of peers. Self-efficacy and the influence of peers were the factors that most influenced the consumption of fruits and vegetables in adolescents.
DOI: 10.6084/m9.figshare.21907626.v1
title: Psychosocial aspects related to fruit and vegetable consumption in adolescents

description: Abstract This study aimed at assessing the association between psychosocial aspects and fruit and vegetable consumption in adolescents. Cross-sectional study developed with 327 adolescents from a public school in Brazil. A questionnaire developed for adolescents was applied to assess the influence of self-efficacy, family, peers, and body image on the consumption of fruits and vegetables. Specific questions assessed the intake frequency of fruits and vegetables, and the mean consumption was estimated using two 24-hour recalls. Scores related to psychosocial aspects were described as mean and median and the weight status was classified based on the body mass index. The average daily consumption of fruits and vegetables was 36.2 g and 45.4 g, respectively. Self-efficacy and the influence of peers were associated with an increase in the amount and frequency of fruits and vegetables consumption. Adolescents with higher scores of self-efficacy had greater average consumption of fruits and vegetables when compared to those with lower scores. The same was observed for the influence of peers. Self-efficacy and the influence of peers were the factors that most influenced the consumption of fruits and vegetables in adolescents.
DOI: 10.6084/m9.figshare.21907624
title: Measles vaccination in Brazil: where have we been and where are we headed?

description: Abstract The re-emergence of vaccine-preventable diseases due to the decline in vaccine coverage (VC) has been documented in several countries. The objective was to analyze the VC, the homogeneity of VC, and measles cases in Brazil from 2011 to 2021, focusing on the period of the COVID-19 pandemic, its temporal trend, space-time distribution, and factors associated with clusters of lower VC. This is an ecological study on measles VC (dose 1), with methods of interrupted time series and evaluation of spatio-temporal disposition, through the sweep test to identify clusters of VC. Starting in 2015, we observe a progressive decline in VC and homogeneity, with an accentuation after 2020, in all regions, particularly in the North and Northeast. Low VC clusters were associated with worse human development indicators, social inequality, and less access to the Family Health Strategy. In Brazil, the pandemic intensified health inequalities with low VC of measles in socially more vulnerable and unequal municipalities. There is a risk of virus circulation, however, the challenge of strengthening primary care, improving health communication and guaranteeing access to the vaccine, reducing missed opportunities for vaccination and vaccine hesitancy, is highlighted.
DOI: 10.6084/m9.figshare.21907624.v1
title: Measles vaccination in Brazil: where have we been and where are we headed?

description: Abstract The re-emergence of vaccine-preventable diseases due to the decline in vaccine coverage (VC) has been documented in several countries. The objective was to analyze the VC, the homogeneity of VC, and measles cases in Brazil from 2011 to 2021, focusing on the period of the COVID-19 pandemic, its temporal trend, space-time distribution, and factors associated with clusters of lower VC. This is an ecological study on measles VC (dose 1), with methods of interrupted time series and evaluation of spatio-temporal disposition, through the sweep test to identify clusters of VC. Starting in 2015, we observe a progressive decline in VC and homogeneity, with an accentuation after 2020, in all regions, particularly in the North and Northeast. Low VC clusters were associated with worse human development indicators, social inequality, and less access to the Family Health Strategy. In Brazil, the pandemic intensified health inequalities with low VC of measles in socially more vulnerable and unequal municipalities. There is a risk of virus circulation, however, the challenge of strengthening primary care, improving health communication and guaranteeing access to the vaccine, reducing missed opportunities for vaccination and vaccine hesitancy, is highlighted.
DOI: 10.6084/m9.figshare.21907629
title: Characteristics associated with the consumption of in natura or minimally processed and ultra-processed foods in one Brazilian metropolitan region

description: Abstract This cross-sectional study aimed to analyze the sociodemographic and lifestyle characteristics associated with the consumption of in natura or minimally processed and ultra-processed foods (UPFs) by adolescents in the Metropolitan Region of Greater Vitória, in Espírito Santo, Brazil. The data were obtained between 2016 and 2017. Logistic regression was adopted for the multivariate analysis. A total of 2,285 adolescents aged between 15 and 19 participated in the study. Greater consumption of minimally processed foods was associated with the adolescent doing paid work (OR=1.27; 95%CI=1.04-1.56), a high family income (OR=1.5; 95%CI=1.10-2.17), and engagement in physical activity (OR=1.9; 95%CI=1.45-2.63). Having brown/black skin (OR=1.3; 95%CI=1.02-1.61) and the habit of eating while surfing the web (OR=1.4; 95%CI=1.02-1.88) increased the chances of consuming UPFs. Being enrolled in a private school and being in the third/fourth year of high school reduced UPF consumption by 41.7% and 37.2%, respectively. It is concluded that greater purchasing power and engagement in physical activity influenced the consumption of minimally processed foods. On the other hand, self-reporting as brown/black and internet use increased the chances of greater UPF consumption.
DOI: 10.6084/m9.figshare.21907629.v1
title: Characteristics associated with the consumption of in natura or minimally processed and ultra-processed foods in one Brazilian metropolitan region

description: Abstract This cross-sectional study aimed to analyze the sociodemographic and lifestyle characteristics associated with the consumption of in natura or minimally processed and ultra-processed foods (UPFs) by adolescents in the Metropolitan Region of Greater Vitória, in Espírito Santo, Brazil. The data were obtained between 2016 and 2017. Logistic regression was adopted for the multivariate analysis. A total of 2,285 adolescents aged between 15 and 19 participated in the study. Greater consumption of minimally processed foods was associated with the adolescent doing paid work (OR=1.27; 95%CI=1.04-1.56), a high family income (OR=1.5; 95%CI=1.10-2.17), and engagement in physical activity (OR=1.9; 95%CI=1.45-2.63). Having brown/black skin (OR=1.3; 95%CI=1.02-1.61) and the habit of eating while surfing the web (OR=1.4; 95%CI=1.02-1.88) increased the chances of consuming UPFs. Being enrolled in a private school and being in the third/fourth year of high school reduced UPF consumption by 41.7% and 37.2%, respectively. It is concluded that greater purchasing power and engagement in physical activity influenced the consumption of minimally processed foods. On the other hand, self-reporting as brown/black and internet use increased the chances of greater UPF consumption.
DOI: 10.6084/m9.figshare.21907630
title: Progressive neuropathy in patients with lepromatous leprosy after multidrug therapy

description: BACKGROUND The lepromatous pole is a stigmatising prototype for patients with leprosy. Generally, these patients have little or no symptoms of peripheral nerve involvement at the time of their diagnosis. However, signs of advanced peripheral neuropathy would be visible during the initial neurological evaluation and could worsen during and after multidrug therapy (MDT). Disabilities caused by peripheral nerve injuries greatly affect these patients’ lives, and the pathophysiological mechanisms underlying nerve damage remain unclear. OBJECTIVES To evaluate the outcome of peripheral neuropathy in patients with lepromatous leprosy (LL) and persistent neuropathic symptoms years after completing MDT. METHODS We evaluated the medical records of 14 patients with LL who underwent nerve biopsies due to worsening neuropathy at least four years after MDT. FINDINGS Neuropathic pain developed in 64.3% of the patients, and a neurological examination showed that most patients had alterations in the medium- and large-caliber fibers at the beginning of treatment. Neurological symptoms and signs deteriorated despite complete MDT and prednisone or thalidomide use for years. Nerve conduction studies showed that sensory nerves were the most affected. MAIN CONCLUSIONS Patients with LL can develop progressive peripheral neuropathy, which continues to develop even when they are on long-term anti-inflammatory and immunosuppressive therapy.
DOI: 10.6084/m9.figshare.21907630.v1
title: Progressive neuropathy in patients with lepromatous leprosy after multidrug therapy

description: BACKGROUND The lepromatous pole is a stigmatising prototype for patients with leprosy. Generally, these patients have little or no symptoms of peripheral nerve involvement at the time of their diagnosis. However, signs of advanced peripheral neuropathy would be visible during the initial neurological evaluation and could worsen during and after multidrug therapy (MDT). Disabilities caused by peripheral nerve injuries greatly affect these patients’ lives, and the pathophysiological mechanisms underlying nerve damage remain unclear. OBJECTIVES To evaluate the outcome of peripheral neuropathy in patients with lepromatous leprosy (LL) and persistent neuropathic symptoms years after completing MDT. METHODS We evaluated the medical records of 14 patients with LL who underwent nerve biopsies due to worsening neuropathy at least four years after MDT. FINDINGS Neuropathic pain developed in 64.3% of the patients, and a neurological examination showed that most patients had alterations in the medium- and large-caliber fibers at the beginning of treatment. Neurological symptoms and signs deteriorated despite complete MDT and prednisone or thalidomide use for years. Nerve conduction studies showed that sensory nerves were the most affected. MAIN CONCLUSIONS Patients with LL can develop progressive peripheral neuropathy, which continues to develop even when they are on long-term anti-inflammatory and immunosuppressive therapy.