cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8313170.v1
title: A multiscale analysis of land use dynamics in the buffer zone of Rio Doce State Park, Minas Gerais, Brazil

description: This article uses a multiscale approach for assessing landscape changes in one of the world’s biodiversity hotspots in Brazil, the Rio Doce State Park (PERD). In this article, we assess land use changes over a 30 year period. Our results show that, while inside the park landscape changes were minimal, in the park buffer zone human induced changes are steadily rising due to an increase in eucalyptus plantations and urban sprawl that grew by 4% and 1.9%, respectively. Agricultural land has been reduced by 6.35%, but there are trends that a form of welcome forest transition has been occurring. We report an increase in native forests from 40,588 ha in 1985 to 45,690 ha in 2015. The analysis of human impacts in the study area delivers very different results when varying the pixel size from 25 ha to 900 m<sup>2</sup>. The former shows a very high level of human influence while the latter reveals small but vital patches of native forest offering hopeful opportunities for sustainable natural resource management in this critical biome. Our work stresses the importance of better targeted policy making and sympathetic land use management of buffer zones of protected areas. Currently, such zones suffer from many development pressures and often experience contradictory policy frameworks which encourage a clash between biodiversity conservation and intensive agro husbandry production. <b>Highlights:</b> • We characterize land use transitions in a hotspot of biodiversity in Brazil. • Analysis at finer resolution show that there is still hope for forest recovery. • For instilling sustainable forest transitions there is the need for fresh governance.
DOI: 10.6084/m9.figshare.8313176.v1
title: Supplemental figures for "Widespread cell-specific prolactin receptor expression in mutiple murine organs"

description: The prolactin receptor (Prlr) mediates not only the multiple effects of prolactin, but also those of the placental lactogens and, in humans, some actions of growth hormone. While Prlr expression has been reported to be widespread in the body, specific cellular expression patterns within tissues are undefined for many organs. One persisting problem in investigating Prlr function is, that the protein is difficult to detect using conventional methods. To allow investigation of Prlr expression with a single cell resolution, we have recently developed a knock-in mouse strain in which Cre recombinase is expressed together with the long isoform of the Prlr using an internal ribosome entry site (IRES). When crossed to a Cre-dependent reporter mouse strain, Cre-mediated recombination will genetically label cells that acutely express the Prlr as well as cells that have transiently expressed the Prlr during development. We report here the anatomical distribution of cells which express the fluorescent reporter GFP in a total of 38 organs prepared from young adult male and female prolactin receptor reporter mice. Our results establish a novel resource for dissecting the functional role of Prlr in multiple murine tissues.<br>
DOI: 10.6084/m9.figshare.8313143
title: Supplementary Material for: Chitosan Oligosaccharide Exerts Anti-Allergic Effect against Shrimp Tropomyosin-Induced Food Allergy by Affecting Th1 and Th2 Cytokines

description: <b><i>Background:</i></b> Shrimp-derived allergen has a serious impact on people’s health. Chitosan oligosaccharide (COS) has anti-allergic action but its function on shrimp allergen-induced allergy and related molecular mechanisms remain unclear. <b><i>Methods:</i></b> COS and its degrees of polymerization (DP) were selected to interact with shrimp tropomyosin (TM) and IgE was measured. A mouse model of food allergy was established by receiving shrimp TM intraperitoneally. The models were treated with different concentrations of COS. Fecal and serum histamine, serum IgE, IgG1 and IgG2a, and inflammatory cytokines were measured. <b><i>Results:</i></b> The main products for COS were DP2–6 with the contents of 6, 40, 26, 16, and 4%, respectively, and reacted with shrimp TM increasingly when COS DP was increased. Severe symptoms of food allergy were observed in the TM group (diarrhea, anaphylactic response, and rectal temperature). In contrast, COS treatment improved these symptoms significantly (<i>p</i> &lt; 0.05). The sensitized mice were desensitized after they were treated with 1 mg/kg COS. COS treatment significantly reduced serum IgE and IgG1 levels, and increased IgG2a levels (<i>p</i> &lt; 0.05). COS consumption decreased fecal and serum histamine. COS treatment reduced Th2 cytokine (IL-4, IL-5, and IL-13) levels and increased the Th1 cytokine (IFN-γ) level (<i>p</i> &lt; 0.05). <b><i>Conclusions:</i></b> COS showed anti-allergy properties by regulating the levels of Th1 and Th2 cytokines.
DOI: 10.6084/m9.figshare.8313122
title: ISCALIMAB-KAHALY-SUPPLEMENTAL

description: <b>Context</b> The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves’ disease (GD) by promoting auto-reactive B cell activation. <b>Objective</b> Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD <b>Design</b> Open label, phase II proof-of-concept study <b>Setting </b>Multicenter <b>Patients </b>Fifteen with GD <b>Intervention</b> Patients received five doses of iscalimab at 10 mg/kg intravenously over 12 weeks. <b>Main outcome measures</b> Thyroid-related hormones and autoantibodies, plasma soluble CD40, free CD40 on B cells, soluble CXCL13, pharmacokinetics, and safety were assessed. <b>Results: </b>The iscalimab intervention resulted in complete CD40 engagement for up to 20 weeks. A clinical response and biochemical euthyroidism was observed in seven of 15 (47%) patients, free T3 and T4 normalized in seven patients who did not received any rescue medication with anti-thyroid drugs (ATD), and 2/15 (13.3%) showed normal TSH. Six (40%) patients required ATD. Serum concentrations of thyrotropin receptor autoantibodies (TSH-R-Ab) significantly declined in all patients (mean 15.3 IU/L versus 4.0 IU/L, 66% reduction, P&lt;0.001) and TSH-R-Ab levels normalized in four (27%). Thyroperoxidase and thyroglobulin autoantibodies significantly decreased in responders. Iscalimab rapidly reduced serum CXCL13 concentrations (94.1 pg./mL at baseline, 68.5 pg./mL, day 15, P&lt;0.001). Twelve (80.0%) patients reported at least one adverse event (AE). All treatment-related AE were mild or moderate and resolved by end of the study. <b>Conclusion</b>: Iscalimab was generally safe and clinically effective in a subgroup of hyperthyroid GD patients. Iscalimab should be tested further to understand better its potential therapeutic benefit.
DOI: 10.6084/m9.figshare.8313101
title: FBA, MH - Copy.sav

description: This is the raw data of the article titled Facebook Use, Facebook Addiction, and Mental Health of Chittagong University Students<b></b>
DOI: 10.6084/m9.figshare.8313122.v1
title: ISCALIMAB-KAHALY-SUPPLEMENTAL

description: <b>Context</b> The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves’ disease (GD) by promoting auto-reactive B cell activation. <b>Objective</b> Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD <b>Design</b> Open label, phase II proof-of-concept study <b>Setting </b>Multicenter <b>Patients </b>Fifteen with GD <b>Intervention</b> Patients received five doses of iscalimab at 10 mg/kg intravenously over 12 weeks. <b>Main outcome measures</b> Thyroid-related hormones and autoantibodies, plasma soluble CD40, free CD40 on B cells, soluble CXCL13, pharmacokinetics, and safety were assessed. <b>Results: </b>The iscalimab intervention resulted in complete CD40 engagement for up to 20 weeks. A clinical response and biochemical euthyroidism was observed in seven of 15 (47%) patients, free T3 and T4 normalized in seven patients who did not received any rescue medication with anti-thyroid drugs (ATD), and 2/15 (13.3%) showed normal TSH. Six (40%) patients required ATD. Serum concentrations of thyrotropin receptor autoantibodies (TSH-R-Ab) significantly declined in all patients (mean 15.3 IU/L versus 4.0 IU/L, 66% reduction, P&lt;0.001) and TSH-R-Ab levels normalized in four (27%). Thyroperoxidase and thyroglobulin autoantibodies significantly decreased in responders. Iscalimab rapidly reduced serum CXCL13 concentrations (94.1 pg./mL at baseline, 68.5 pg./mL, day 15, P&lt;0.001). Twelve (80.0%) patients reported at least one adverse event (AE). All treatment-related AE were mild or moderate and resolved by end of the study. <b>Conclusion</b>: Iscalimab was generally safe and clinically effective in a subgroup of hyperthyroid GD patients. Iscalimab should be tested further to understand better its potential therapeutic benefit.
DOI: 10.6084/m9.figshare.8313101.v1
title: FBA, MH - Copy.sav

description: This is the raw data of the article titled Facebook Use, Facebook Addiction, and Mental Health of Chittagong University Students<b></b>
DOI: 10.6084/m9.figshare.8313122.v2
title: ISCALIMAB-KAHALY-SUPPLEMENTAL

description: <b>Context</b> The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves’ disease (GD) by promoting auto-reactive B cell activation. <b>Objective</b> Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD <b>Design</b> Open label, phase II proof-of-concept study <b>Setting </b>Multicenter <b>Patients </b>Fifteen with GD <b>Intervention</b> Patients received five doses of iscalimab at 10 mg/kg intravenously over 12 weeks. <b>Main outcome measures</b> Thyroid-related hormones and autoantibodies, plasma soluble CD40, free CD40 on B cells, soluble CXCL13, pharmacokinetics, and safety were assessed. <b>Results: </b>The iscalimab intervention resulted in complete CD40 engagement for up to 20 weeks. A clinical response and biochemical euthyroidism was observed in seven of 15 (47%) patients, free T3 and T4 normalized in seven patients who did not received any rescue medication with anti-thyroid drugs (ATD), and 2/15 (13.3%) showed normal TSH. Six (40%) patients required ATD. Serum concentrations of thyrotropin receptor autoantibodies (TSH-R-Ab) significantly declined in all patients (mean 15.3 IU/L versus 4.0 IU/L, 66% reduction, P&lt;0.001) and TSH-R-Ab levels normalized in four (27%). Thyroperoxidase and thyroglobulin autoantibodies significantly decreased in responders. Iscalimab rapidly reduced serum CXCL13 concentrations (94.1 pg./mL at baseline, 68.5 pg./mL, day 15, P&lt;0.001). Twelve (80.0%) patients reported at least one adverse event (AE). All treatment-related AE were mild or moderate and resolved by end of the study. <b>Conclusion</b>: Iscalimab was generally safe and clinically effective in a subgroup of hyperthyroid GD patients. Iscalimab should be tested further to understand better its potential therapeutic benefit.
DOI: 10.6084/m9.figshare.8313056
title: Supplementary Material for: Frequency of Hypoglycaemia after Different Bariatric Surgical Procedures

description: <b><i>Objectives:</i></b> The frequency of postprandial hypoglycaemia after different operative procedures of bariatric surgery (BS) is unknown, although this complication is potentially dangerous. Predictors and severity of hypoglycaemia after Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy, and gastric banding were investigated in a large prospective study. <b><i>Methods:</i></b> This study was performed at an excellence centre for BS at a tertiary care institution. Data of 333 patients (mean BMI: 44.9 ± 9.6 kg/m<sup>2</sup>; mean age: 40 ± 10 years; 80.7% women) were analysed in a prospective study with a 2-year observation period after BS. All patients underwent a 2-hour oral glucose tolerance test (OGTT) with measurements of blood glucose (BG) and insulin. For the purpose of this study, hypoglycaemia was defined as a post-challenge BG &lt;2.8 mmol/L during the OGTT. <b><i>Results:</i></b> 72 (25.6%) of 281 patients showed post-challenge hypoglycaemia after surgery. Hypoglycaemia was different after various procedures: 32.6% of patients after RYGB, 22.6% after sleeve gastrectomy, but only 2.3% after gastric banding had hypoglycaemia. In the whole group, patients with hypoglycaemia had lost more weight (<i>p</i> = 0.013), had a slightly greater decrease in BMI (<i>p</i> = 0.037), a greater change in 2-hour post-challenge BG (<i>p</i> = 0.001), and a smaller change in 1-hour post-challenge insulin (<i>p</i> = 0.004) compared to patients without hypoglycaemia. <b><i>Conclusion:</i></b> This prospective study shows a higher prevalence of severe hypoglycaemia (25.6%) after BS than anticipated from retrospective registers. A systematic evaluation of glucose and insulin levels by OGTT 2 years post-surgery may help to identify patients at increased risk for symptomatic and asymptomatic hypoglycaemia.
DOI: 10.6084/m9.figshare.8312957
title: Statistics of Illumina-based RNA-seq data and quantification

description: Statistics of Illumina-based RNA-seq data and quantification
DOI: 10.6084/m9.figshare.8312957.v1
title: Statistics of Illumina-based RNA-seq data and quantification

description: Statistics of Illumina-based RNA-seq data and quantification
DOI: 10.6084/m9.figshare.8312825
title: List of raw reads for each accession

description: List of raw reads for each accession
DOI: 10.6084/m9.figshare.8312822
title: RPKM values and functional description for transcripts in all samples.xlsx

description: RPKM values and functional description for transcripts in all samples
DOI: 10.6084/m9.figshare.8312825.v1
title: List of raw reads for each accession

description: List of raw reads for each accession
DOI: 10.6084/m9.figshare.8312822.v1
title: RPKM values and functional description for transcripts in all samples.xlsx

description: RPKM values and functional description for transcripts in all samples
DOI: 10.6084/m9.figshare.8312825.v2
title: List of raw reads for each accession

description: List of raw reads for each accession
DOI: 10.6084/m9.figshare.8312804
title: Teka-Teki Silang Hasil Pelatihan Pembelajaran Berbasis Smartphone

description: Berikut ini adalah hasil kinerja para peserta Pelatihan Pembelajaran Berbasis <i>Smartphone</i> dalam membuat Teka Teki Silang memanfaatkan perangkat lunak <i>EclipseCrossword</i>. Pelatihan ini diselenggarakan atas kerja sama MGMP Fisika SMA Kabupaten Klaten dengan Dinas Pendidikan Jawa Tengah Wilayah V di SMA Negeri 3 Klaten pada tanggal 27-28 April 2019. Pelatihan kemudian dilanjutkan dengan penugasan secara daring dari tanggal 29 April hingga 4 Mei 2019. <br> Laporan kegiatan ini ditulis dalam bentuk artikel "Pembuatan Media Pembelajaran Memanfaatkan Aplikasi Quizlet, Quizizz, dan EclipseCrossword" yang dikirimkan ke Jurnal Pengabdian Pada Masyarakat http://ppm.ejournal.id/
DOI: 10.6084/m9.figshare.8312780
title: ViralEncephaCompare

description: this data decribed enterovirus infection from CSF specimen of 103 children patients with suspected viral encephalitis.
DOI: 10.6084/m9.figshare.8312780.v2
title: ViralEncephaCompare

description: this data decribed enterovirus infection from CSF specimen of 103 children patients with suspected viral encephalitis.
DOI: 10.6084/m9.figshare.8312774
title: Study on the Seasonal Stability Evolution Law of Expansive Soft Rock Roadway

description: In rock engineering such as mine engineering and tunnel engineering, the rock mass structure plays a key role in the strength, seepage and stability of the rock mass. Therefore, the geometric parameter statistics of structural planes in rock mass engineering is an important geological survey work. Traditional rock mass structural plane measurement methods are limited by various on-site conditions. With the application of advanced measurement technologies in underground mines, the measurement methods of rock mass structural planes have also been updated. Among them, photogrammetry and 3D laser scanning measurement are new methods suitable for measuring the structural planes of underground rock mass. Through the detailed comparison and analysis of three typical structural plane measurement methods, the 3D laser scanning technology has proven to have an incomparable advantage in the collection of rock mass structure measurement. It has explored a new way for the rapid collection of rock mass structure plane occurrence in areas with harsh geological conditions.
DOI: 10.6084/m9.figshare.8312774.v1
title: Study on the Seasonal Stability Evolution Law of Expansive Soft Rock Roadway

description: In rock engineering such as mine engineering and tunnel engineering, the rock mass structure plays a key role in the strength, seepage and stability of the rock mass. Therefore, the geometric parameter statistics of structural planes in rock mass engineering is an important geological survey work. Traditional rock mass structural plane measurement methods are limited by various on-site conditions. With the application of advanced measurement technologies in underground mines, the measurement methods of rock mass structural planes have also been updated. Among them, photogrammetry and 3D laser scanning measurement are new methods suitable for measuring the structural planes of underground rock mass. Through the detailed comparison and analysis of three typical structural plane measurement methods, the 3D laser scanning technology has proven to have an incomparable advantage in the collection of rock mass structure measurement. It has explored a new way for the rapid collection of rock mass structure plane occurrence in areas with harsh geological conditions.
DOI: 10.6084/m9.figshare.8312525
title: dataBrachy.tar.gz

description: Data for the submitted paper: <br>Pouso, Goodson, Silva: "Preoptic area activation and vasotocin involvement in the reproductive behavior of a weakly pulse-type electric fish, Brachyhypopomus gauderio"Submitted to Frontiers in Integrative neuroscience.<br>
DOI: 10.6084/m9.figshare.8312456
title: Precios.xlsx

description: Lista de precios de apertura y cierre de Santander, BBVA, Banco del bajío y Banorte. CLIDI
DOI: 10.6084/m9.figshare.8312525.v1
title: dataBrachy.tar.gz

description: Data for the submitted paper: <br>Pouso, Goodson, Silva: "Preoptic area activation and vasotocin involvement in the reproductive behavior of a weakly pulse-type electric fish, Brachyhypopomus gauderio"Submitted to Frontiers in Integrative neuroscience.<br>
DOI: 10.6084/m9.figshare.8312447
title: supplemental.docx

description: supplemental methods
DOI: 10.6084/m9.figshare.8312456.v1
title: Precios.xlsx

description: Lista de precios de apertura y cierre de Santander, BBVA, Banco del bajío y Banorte. CLIDI
DOI: 10.6084/m9.figshare.8312447.v1
title: supplemental.docx

description: supplemental methods
DOI: 10.6084/m9.figshare.8312447.v3
title: supplemental.docx

description: supplemental methods
DOI: 10.6084/m9.figshare.8312447.v2
title: supplemental.docx

description: supplemental methods
DOI: 10.6084/m9.figshare.8312408
title: Low Level Repository FAIR Overview

description: This dataset acts as a reference point for a practice paper that surveyed 5 subject specific data repositories and 5 generalist data repositories.<br>This dataset offers a high level analysis of 10 repositories in an attempt not only to assess the levels of FAIR-ness, but to provide a number of simple recommendations to help standardize the academy’s data repository infrastructure and bolster interoperability<br>
DOI: 10.6084/m9.figshare.8312366
title: Variation in different measures of diversity during primary succession on a tropical coastal dune

description: <b>Background</b>: The understanding of the processes that govern community assembly during ecological succession helps determine the ecological attributes in restoration and monitoring programmes. <b>Aims</b>: The aim of this long-term study of primary succession was to analyse changes in species richness, diversity, taxonomic distinctness and functional types to understand community assembly processes. <b>Methods</b>: For 25 years, species turnover was monitored in 150 permanent plots in a dune system on the coast of the Gulf of Mexico. <b>Results</b>: Earliest successional states had low species diversity and richness, a high unevenness in the taxonomic tree structure, and a lower number of functional groups, with psammophytes being dominant. Richness and diversity increased in a humped-back shape with intermediate states reaching the highest values. Succession generated taxonomic trees that became less uneven and more diverse, and the diversity of functional groups increased. <b>Conclusions</b>: The processes underlying community assembly are complex during succession: sand movement acts as an environmental filter affecting the dominant functional groups, and species interactions probably change from facilitation to competition. The understanding of the combined processes affecting the different measures of diversity over time can improve the effectiveness of restoration and conservation practice in dune systems.
DOI: 10.6084/m9.figshare.8312372
title: tree newick

description: the alignment and tree files of phylogenetic analysis
DOI: 10.6084/m9.figshare.8312366.v2
title: Variation in different measures of diversity during primary succession on a tropical coastal dune

description: <b>Background</b>: The understanding of the processes that govern community assembly during ecological succession helps determine the ecological attributes in restoration and monitoring programmes. <b>Aims</b>: The aim of this long-term study of primary succession was to analyse changes in species richness, diversity, taxonomic distinctness and functional types to understand community assembly processes. <b>Methods</b>: For 25 years, species turnover was monitored in 150 permanent plots in a dune system on the coast of the Gulf of Mexico. <b>Results</b>: Earliest successional states had low species diversity and richness, a high unevenness in the taxonomic tree structure, and a lower number of functional groups, with psammophytes being dominant. Richness and diversity increased in a humped-back shape with intermediate states reaching the highest values. Succession generated taxonomic trees that became less uneven and more diverse, and the diversity of functional groups increased. <b>Conclusions</b>: The processes underlying community assembly are complex during succession: sand movement acts as an environmental filter affecting the dominant functional groups, and species interactions probably change from facilitation to competition. The understanding of the combined processes affecting the different measures of diversity over time can improve the effectiveness of restoration and conservation practice in dune systems.