cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21201016
title: Sunflower cake in the diets of lightweight laying pullets: Effects on the growth phase and the beginning of production cycle

description: ABSTRACT The use of sunflower cake (SC) in animal feed has been studied mainly due to the characteristics that are given to them, since this by-product when incorporated in the feed can increase the economic viability and the nutritional value of the diet. The objective of this study was to evaluate the inclusion of sunflower cake in lightweight pullet diets and check their nutrient digestibility and metabolizable energy for several parameters, including diet, performance, body composition, nutrient retention, energy metabolism at the growth phase, performance of egg production, sexual maturity, and egg quality at the beginning of the laying phase. We distributed a total of 648 pullets in our study, which was a completely randomized design including six treatments with six replicates of 18 pullets each. The treatments included diets with 0, 5, 10, 15, 20, and 25% SC. Our study results concluded that pullets fed with diets containing SC showed a reduction (P&lt;0.01) in nutrient digestibility and metabolizable energy compared to those fed with the control diet. Pullets fed with 25% SC showed an increase (P&lt;0.01) in feed intake and feed conversion ratio. However, dietary inclusion of SC in pullet diets did not influence (P&gt;0.05) their body composition, nutrient retention, energy metabolism, sexual maturity, egg-laying performance, and egg quality of laying hens between 18 and 35 weeks of their age. Therefore, up to 25% of SC could be included in the diet of lightweight laying pullets in the growth phase since it exhibited no residual effect on their productive performance at the beginning of the laying phase.
DOI: 10.6084/m9.figshare.21201016.v1
title: Sunflower cake in the diets of lightweight laying pullets: Effects on the growth phase and the beginning of production cycle

description: ABSTRACT The use of sunflower cake (SC) in animal feed has been studied mainly due to the characteristics that are given to them, since this by-product when incorporated in the feed can increase the economic viability and the nutritional value of the diet. The objective of this study was to evaluate the inclusion of sunflower cake in lightweight pullet diets and check their nutrient digestibility and metabolizable energy for several parameters, including diet, performance, body composition, nutrient retention, energy metabolism at the growth phase, performance of egg production, sexual maturity, and egg quality at the beginning of the laying phase. We distributed a total of 648 pullets in our study, which was a completely randomized design including six treatments with six replicates of 18 pullets each. The treatments included diets with 0, 5, 10, 15, 20, and 25% SC. Our study results concluded that pullets fed with diets containing SC showed a reduction (P&lt;0.01) in nutrient digestibility and metabolizable energy compared to those fed with the control diet. Pullets fed with 25% SC showed an increase (P&lt;0.01) in feed intake and feed conversion ratio. However, dietary inclusion of SC in pullet diets did not influence (P&gt;0.05) their body composition, nutrient retention, energy metabolism, sexual maturity, egg-laying performance, and egg quality of laying hens between 18 and 35 weeks of their age. Therefore, up to 25% of SC could be included in the diet of lightweight laying pullets in the growth phase since it exhibited no residual effect on their productive performance at the beginning of the laying phase.
DOI: 10.6084/m9.figshare.21201019
title: Comparison of the efficacy of latanoprost versus dorzolamide/timolol fixed combination therapy in patients with pseudoexfoliative glaucoma according to glaucoma stage

description: ABSTRACT Purpose: Only a few trials have compared the intraocular pressure-lowering effects of prostaglandin analogs to carbonic anhydrase inhibitor plus beta-blocker fixed-dose combination therapy in patients with pseudoexfoliative glaucoma. Furthermore, the influence of the glaucoma stage on the intraocular pressure-lowering effects of these drug types has not been studied. The purpose of this study was to compare the IOP-lowering efficacy of latanoprost, a prostaglandin analog versus dorzolamide/timolol fixed combination, a carbonic anhydrase inhibitor plus beta-blocker fixed-dose combination therapy, in patients with pseudoexfoliative glaucoma based on glaucoma stage. Methods: The data of 32 eyes (32 patients) diagnosed with uniocular pseudoexfoliative glaucoma and treated with topical latanoprost (Group 1) or dorzolamide/timolol fixed combination (Group 2) were retrospectively assessed. The groups were subdivided into early and moderate-advanced stages. Patients’ demographics, baseline intraocular pressure, final intraocular pressure, and intraocular pressure difference (the difference between the baseline and final intraocular pressure) were determined from medical records and compared between groups and according to glaucoma stage. Results: The mean drug use duration was 17.7 ± 13.5 months. No significant differences in mean baseline intraocular pressure, mean final intraocular pressure and mean intraocular pressure difference between Groups 1 and 2. In Group 2, the mean intraocular pressure difference was significantly greater in patients with early versus moderate-advanced stage glaucoma (p=0.015). The difference, however, was not detected in Group 1. The mean intraocular pressure difference in early-stage glaucoma was significantly greater in Group 2 versus 1 (p=0.033). Conclusions: Latanoprost and dorzolamide/timolol fixed combination are effective treatments for newly diagnosed pseudoexfoliative glaucoma. In early-stage pseudoexfoliative glaucoma, greater intraocular pressure reduction was noted with dorzolamide/timolol fixed combination than with latanoprost; thus, dorzolamide/timolol fixed combination should be considered when a significant decrease in intraocular pressure is desired in early-stage glaucoma.
DOI: 10.6084/m9.figshare.21201019.v1
title: Comparison of the efficacy of latanoprost versus dorzolamide/timolol fixed combination therapy in patients with pseudoexfoliative glaucoma according to glaucoma stage

description: ABSTRACT Purpose: Only a few trials have compared the intraocular pressure-lowering effects of prostaglandin analogs to carbonic anhydrase inhibitor plus beta-blocker fixed-dose combination therapy in patients with pseudoexfoliative glaucoma. Furthermore, the influence of the glaucoma stage on the intraocular pressure-lowering effects of these drug types has not been studied. The purpose of this study was to compare the IOP-lowering efficacy of latanoprost, a prostaglandin analog versus dorzolamide/timolol fixed combination, a carbonic anhydrase inhibitor plus beta-blocker fixed-dose combination therapy, in patients with pseudoexfoliative glaucoma based on glaucoma stage. Methods: The data of 32 eyes (32 patients) diagnosed with uniocular pseudoexfoliative glaucoma and treated with topical latanoprost (Group 1) or dorzolamide/timolol fixed combination (Group 2) were retrospectively assessed. The groups were subdivided into early and moderate-advanced stages. Patients’ demographics, baseline intraocular pressure, final intraocular pressure, and intraocular pressure difference (the difference between the baseline and final intraocular pressure) were determined from medical records and compared between groups and according to glaucoma stage. Results: The mean drug use duration was 17.7 ± 13.5 months. No significant differences in mean baseline intraocular pressure, mean final intraocular pressure and mean intraocular pressure difference between Groups 1 and 2. In Group 2, the mean intraocular pressure difference was significantly greater in patients with early versus moderate-advanced stage glaucoma (p=0.015). The difference, however, was not detected in Group 1. The mean intraocular pressure difference in early-stage glaucoma was significantly greater in Group 2 versus 1 (p=0.033). Conclusions: Latanoprost and dorzolamide/timolol fixed combination are effective treatments for newly diagnosed pseudoexfoliative glaucoma. In early-stage pseudoexfoliative glaucoma, greater intraocular pressure reduction was noted with dorzolamide/timolol fixed combination than with latanoprost; thus, dorzolamide/timolol fixed combination should be considered when a significant decrease in intraocular pressure is desired in early-stage glaucoma.
DOI: 10.6084/m9.figshare.21201022
title: Prevalence and factors associated with pelvic floor dysfunction in university women: a cross-sectional study

description: Abstract Introduction Urinary incontinence (UI), fecal inconti-nence (FI), and genito-pelvic pain or penetration disorder (GPPPD) are considered pelvic floor dysfunction (PFD), and are mainly characterized by poor functionality of the pelvic floor muscles. Despite the relevance of these dysfunctions in women's lives, the demand for care is low. Objective To analyze the prevalence of PFD, in university women, and factors associated with PFD. Methods This is a cross-sectional study conducted at São Paulo State University, Marília, SP, Brazil, with undergraduate and/or postgraduate women aged over 18 years. An online questionnaire containing 40 open and multiple-choice questions about PFD was developed by the authors and a Google form was disclosed via social media (Facebook, Instagram) to the participants. The questionnaire was applied between April and July 2020. Results A sample of 707 participants was included. The average age was 22.5 ± 21.0 years old. The most prevalent PFD was GPPPD, reported by 30.7% of women, followed by UI (16.8%) and FI (3.2%). PFD was significant less reported in the Midwest region compared to other regions (p = 0.015) and significantly more prevalent in women who attended public university (p = 0.038), in women with UI, FI, and GPPPD. The association-test showed that attending public university showed association to UI (p &lt; 0.001), FI (p = 0.008) and GPPPD (p = 0.006). In addition, parity showed association with GPPD (p = 0.032) and to attend health courses with UI (p = 0.002). Conclusion PFD is prevalent among university women and GPPPD was the most recurrent, followed by UI and FI. GPPPD was associated with parity and attending a public university. UI was associated with attending public university and health courses. FI was associated with attending a public university.
DOI: 10.6084/m9.figshare.21201022.v1
title: Prevalence and factors associated with pelvic floor dysfunction in university women: a cross-sectional study

description: Abstract Introduction Urinary incontinence (UI), fecal inconti-nence (FI), and genito-pelvic pain or penetration disorder (GPPPD) are considered pelvic floor dysfunction (PFD), and are mainly characterized by poor functionality of the pelvic floor muscles. Despite the relevance of these dysfunctions in women's lives, the demand for care is low. Objective To analyze the prevalence of PFD, in university women, and factors associated with PFD. Methods This is a cross-sectional study conducted at São Paulo State University, Marília, SP, Brazil, with undergraduate and/or postgraduate women aged over 18 years. An online questionnaire containing 40 open and multiple-choice questions about PFD was developed by the authors and a Google form was disclosed via social media (Facebook, Instagram) to the participants. The questionnaire was applied between April and July 2020. Results A sample of 707 participants was included. The average age was 22.5 ± 21.0 years old. The most prevalent PFD was GPPPD, reported by 30.7% of women, followed by UI (16.8%) and FI (3.2%). PFD was significant less reported in the Midwest region compared to other regions (p = 0.015) and significantly more prevalent in women who attended public university (p = 0.038), in women with UI, FI, and GPPPD. The association-test showed that attending public university showed association to UI (p &lt; 0.001), FI (p = 0.008) and GPPPD (p = 0.006). In addition, parity showed association with GPPD (p = 0.032) and to attend health courses with UI (p = 0.002). Conclusion PFD is prevalent among university women and GPPPD was the most recurrent, followed by UI and FI. GPPPD was associated with parity and attending a public university. UI was associated with attending public university and health courses. FI was associated with attending a public university.
DOI: 10.6084/m9.figshare.21201024
title: Plantar pressure during gait: norm-referenced measurement for Brazilian healthy adults using the Footwork Pro® System

description: Abstract Introduction The measurement of plantar pressure is an important component in the evaluation of the locomotive system. However, the absence of norm-referenced measurement poses limitations to its use. Objective To verify the influence of gender on plantar pressure during gait in healthy adults and to propose norm-referenced measurement that may be used as a reference for monitoring. Methods The study included 353 healthy participants (158 females and 195 males), aged between 20 and 64 years, and with a normal foot posture. Using a pressure platform, the peak plantar pressure and pressure-time integrals were measured in three areas of the foot: forefoot, midfoot, and hindfoot. Results Both indicators of plantar pressure showed no significant differences between genders (p ≤ 0.05). Higher peak plantar pressure was found in the forefoot region, while a higher pressure-time integral was found in the hindfoot region. Percentile distribution values were made available for the data set of females and males. Conclusion The available norm-referenced measurement may be used to identify pathological gait parameters, monitor the efficacy of therapeutic interventions, and detect individuals in need of referral for a more sophisticated and detailed evaluation.
DOI: 10.6084/m9.figshare.21201024.v1
title: Plantar pressure during gait: norm-referenced measurement for Brazilian healthy adults using the Footwork Pro® System

description: Abstract Introduction The measurement of plantar pressure is an important component in the evaluation of the locomotive system. However, the absence of norm-referenced measurement poses limitations to its use. Objective To verify the influence of gender on plantar pressure during gait in healthy adults and to propose norm-referenced measurement that may be used as a reference for monitoring. Methods The study included 353 healthy participants (158 females and 195 males), aged between 20 and 64 years, and with a normal foot posture. Using a pressure platform, the peak plantar pressure and pressure-time integrals were measured in three areas of the foot: forefoot, midfoot, and hindfoot. Results Both indicators of plantar pressure showed no significant differences between genders (p ≤ 0.05). Higher peak plantar pressure was found in the forefoot region, while a higher pressure-time integral was found in the hindfoot region. Percentile distribution values were made available for the data set of females and males. Conclusion The available norm-referenced measurement may be used to identify pathological gait parameters, monitor the efficacy of therapeutic interventions, and detect individuals in need of referral for a more sophisticated and detailed evaluation.
DOI: 10.6084/m9.figshare.21201025
title: Post-trauma complex orthodontic approach: the impact of psychological issues of bullying on treatment decision

description: ABSTRACT Objective: This article aims to discuss the multidisciplinary approach required in the treatment of cases of impaction and ankylosis of permanent teeth, associated with a history of trauma, considering the psychological state of the child and family when faced with a traumatic case of bullying, by reporting the complex treatment of a central incisor needing to be orthodontically moved across the midline. Conclusion: This clinical case was a major challenge, which included complex multidisciplinary procedures. Results and stability after 26 months of retention indicated successful orthodontic space closure of two maxillary teeth, without the use of implants or prostheses, in an adolescent patient who had a history of dental trauma, alveolar bone loss, and an uncertain initial prognosis.
DOI: 10.6084/m9.figshare.21201025.v1
title: Post-trauma complex orthodontic approach: the impact of psychological issues of bullying on treatment decision

description: ABSTRACT Objective: This article aims to discuss the multidisciplinary approach required in the treatment of cases of impaction and ankylosis of permanent teeth, associated with a history of trauma, considering the psychological state of the child and family when faced with a traumatic case of bullying, by reporting the complex treatment of a central incisor needing to be orthodontically moved across the midline. Conclusion: This clinical case was a major challenge, which included complex multidisciplinary procedures. Results and stability after 26 months of retention indicated successful orthodontic space closure of two maxillary teeth, without the use of implants or prostheses, in an adolescent patient who had a history of dental trauma, alveolar bone loss, and an uncertain initial prognosis.
DOI: 10.6084/m9.figshare.21201027
title: Prevalence of malocclusion in public school students in the mixed dentition phase and its association with early loss of deciduous teeth

description: ABSTRACT Objective: To determine the prevalence of malocclusion and its association with the early loss of deciduous teeth and other factors in children in the mixed dentition phase, aged six to eight years, enrolled in public schools in southern Brazil. Methods: A cross-sectional study was conducted with a representative sample of 528 children from municipal public schools in 2009. Data collection involved a clinical examination for the determination of early tooth loss, dental caries, tongue pressure and malocclusion (outcome), as well as the administration of a questionnaire. Poisson regression analysis with robust variance was used to model the association between malocclusion and the independent variables. Results: The prevalence of malocclusion and early tooth loss was 69.1% and 21.8%, respectively. In the raw data analysis, malocclusion was associated with age, early tooth loss, dental caries and tongue pressure. After the adjustment, the likelihood of malocclusion was greater among children older than eight years, those who exerted tongue pressure on the teeth and those with early tooth loss. The likelihood of malocclusion was 24% greater among children with early tooth loss, compared to those without tooth loss. Conclusion: The early loss of deciduous teeth was associated with the occurrence of malocclusion in the children studied.
DOI: 10.6084/m9.figshare.21201030
title: RNP-world: The ultimate essence of life is a ribonucleoprotein process

description: Abstract The fundamental essence of life is based on process of interaction between nucleic acids and proteins. In a prebiotic world, amino acids, peptides, ions, and other metabolites acted in protobiotic routes at the same time on which RNAs performed catalysis and self-replication. Nevertheless, it was only when nucleic acids and peptides started to interact together in an organized process that life emerged. First, the ignition was sparked with the formation of a Peptidyl Transferase Center (PTC), possibly by concatenation of proto-tRNAs. This molecule that would become the catalytic site of ribosomes started a process of self-organization that gave origin to a protoorganism named FUCA, a ribonucleic ribosomal-like apparatus capable to polymerize amino acids. In that sense, we review hypotheses about the origin and early evolution of the genetic code. Next, populations of open biological systems named progenotes were capable of accumulating and exchanging genetic material, producing the first genomes. Progenotes then evolved in two paths: some presented their own ribosomes and others used available ribosomes in the medium to translate their encoded information. At some point, two different types of organisms emerged from populations of progenotes: the ribosome-encoding organisms (cells) and the capsid-encoding organisms (viruses).
DOI: 10.6084/m9.figshare.21201030.v1
title: RNP-world: The ultimate essence of life is a ribonucleoprotein process

description: Abstract The fundamental essence of life is based on process of interaction between nucleic acids and proteins. In a prebiotic world, amino acids, peptides, ions, and other metabolites acted in protobiotic routes at the same time on which RNAs performed catalysis and self-replication. Nevertheless, it was only when nucleic acids and peptides started to interact together in an organized process that life emerged. First, the ignition was sparked with the formation of a Peptidyl Transferase Center (PTC), possibly by concatenation of proto-tRNAs. This molecule that would become the catalytic site of ribosomes started a process of self-organization that gave origin to a protoorganism named FUCA, a ribonucleic ribosomal-like apparatus capable to polymerize amino acids. In that sense, we review hypotheses about the origin and early evolution of the genetic code. Next, populations of open biological systems named progenotes were capable of accumulating and exchanging genetic material, producing the first genomes. Progenotes then evolved in two paths: some presented their own ribosomes and others used available ribosomes in the medium to translate their encoded information. At some point, two different types of organisms emerged from populations of progenotes: the ribosome-encoding organisms (cells) and the capsid-encoding organisms (viruses).
DOI: 10.6084/m9.figshare.21201031
title: Ultraviolet radiation and the human eye

description: ABSTRACT This work is a critical review of the current understanding of the effect of ultraviolet radiation on the eye. It deals with the classification of this radiation, environmental level, and the factors that determine it, along with penetration into the human eye, toxicity to ocular structures, associated morbidities, events that may increase the vulnerability of the eye, and artificial eye filters.
DOI: 10.6084/m9.figshare.21201031.v1
title: Ultraviolet radiation and the human eye

description: ABSTRACT This work is a critical review of the current understanding of the effect of ultraviolet radiation on the eye. It deals with the classification of this radiation, environmental level, and the factors that determine it, along with penetration into the human eye, toxicity to ocular structures, associated morbidities, events that may increase the vulnerability of the eye, and artificial eye filters.
DOI: 10.6084/m9.figshare.21201034
title: Breaking bad news in ophthalmology: a literature review

description: ABSTRACT Medical specialties have recognized that breaking bad news assists clinical practice by mitigating the impact of difficult conversations. This scenario also encourages various studies on breaking bad news in ophthalmology since certain ocular diagnoses can be considered bad news. Thus, the objective is to review the scientific literature on breaking bad news in ophthalmology. The literature databases like MEDLINE/PUBMED, EMBASE, LILACS, SCOPUS, COCHRANE, and SCIELO, were screened for related research publications. Two independent reviewers read all the articles and short-listed the most relevant ones. Seven articles, in the formats of original article, review, editorial, oral communication, and correspondence, were reviewed. Conclusively it reveals that ophthalmologists are concerned with communicating bad news effectively but lack related studies. Nevertheless, there is a growing realization that training in breaking bad news can increase physicians’ confidence during communication, thus, benefiting the therapeutic relationship with the patient and his family. Therefore, it would be valuable to include breaking bad news training in the curriculum of residencies.