cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23659364
title: Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report

description: ABSTRACT In equatorial Brazil, the association of Burkitt lymphoma and Epstein–Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein–Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient’s condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.
DOI: 10.6084/m9.figshare.23659364.v1
title: Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report

description: ABSTRACT In equatorial Brazil, the association of Burkitt lymphoma and Epstein–Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein–Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient’s condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.
DOI: 10.6084/m9.figshare.22032314
title: A competing risk survival analysis of the sociodemographic factors of COVID-19 in-hospital mortality in Ecuador

description: This study aimed to analyze the effect of sociodemographic characteristics on COVID-19 in-hospital mortality in Ecuador from March 1 to December 31, 2020. This retrospective longitudinal study was performed with data from publicly accessible registries of the Ecuadorian National Institute of Statistics and Censuses (INEC). Data underwent a competing risk analysis with estimates of the cumulative incidence function (CIF). The effect of covariates on CIFs was estimated using the Fine-Gray model and results were expressed as adjusted subdistribution hazard ratios (SHR). The analysis included 30,991 confirmed COVID-19 patients with a mean age of 56.57±18.53 years; 60.7% (n = 18,816) were men and 39.3% (n = 12,175) were women. Being of advanced age, especially older than or equal to 75 years (SHR = 17.97; 95%CI: 13.08-24.69), being a man (SHR = 1.29; 95%CI: 1.22-1.36), living in rural areas (SHR = 1.18; 95%CI: 1.10-1.26), and receiving care in a public health center (SHR = 1.64; 95%CI: 1.51-1.78) were factors that increased the incidence of death from COVID-19, while living at an elevation higher than 2,500 meters above sea level (SHR = 0.69; 95%CI: 0.66-0.73) decreased this incidence. Since the incidence of death for individuals living in rural areas and who received medical care from the public sector was higher, income and poverty are important factors in the final outcome of this disease.
DOI: 10.6084/m9.figshare.22032314.v1
title: A competing risk survival analysis of the sociodemographic factors of COVID-19 in-hospital mortality in Ecuador

description: This study aimed to analyze the effect of sociodemographic characteristics on COVID-19 in-hospital mortality in Ecuador from March 1 to December 31, 2020. This retrospective longitudinal study was performed with data from publicly accessible registries of the Ecuadorian National Institute of Statistics and Censuses (INEC). Data underwent a competing risk analysis with estimates of the cumulative incidence function (CIF). The effect of covariates on CIFs was estimated using the Fine-Gray model and results were expressed as adjusted subdistribution hazard ratios (SHR). The analysis included 30,991 confirmed COVID-19 patients with a mean age of 56.57±18.53 years; 60.7% (n = 18,816) were men and 39.3% (n = 12,175) were women. Being of advanced age, especially older than or equal to 75 years (SHR = 17.97; 95%CI: 13.08-24.69), being a man (SHR = 1.29; 95%CI: 1.22-1.36), living in rural areas (SHR = 1.18; 95%CI: 1.10-1.26), and receiving care in a public health center (SHR = 1.64; 95%CI: 1.51-1.78) were factors that increased the incidence of death from COVID-19, while living at an elevation higher than 2,500 meters above sea level (SHR = 0.69; 95%CI: 0.66-0.73) decreased this incidence. Since the incidence of death for individuals living in rural areas and who received medical care from the public sector was higher, income and poverty are important factors in the final outcome of this disease.
DOI: 10.6084/m9.figshare.22268848
title: Hepatitis A seroprevalence among special populations in the Rio de Janeiro Metropolitan Area, Brazil

description: The objectives were to estimate hepatitis A virus seroprevalence in subjects attending to a travel medicine and immunization clinic in Rio de Janeiro, Brazil, and to develop a prediction model for hepatitis A virus seroprevalence. This retrospective research included individuals sequentially from April 2011 to June 2019 at a travel medicine and special population immunization clinic with an anti-hepatitis A virus IgG chemiluminescence result. Participants’ data were verified via electronic medical records. Data were split into development and validation set taking 2018 as the date break. A cross-validated elastic generalized linear model with binomial distribution was performed. In total, 2,944 subjects were analyzed. Hepatitis A virus overall seroprevalence was 67.8%. Health professionals, travelers, and those who had contact with immunocompromised subjects had lower seroprevalence (40%-55%), whereas subjects with chronic conditions (heart, lung, and liver) ranged from 89% to 94%. The retained predictors in the final model were sex, age, year of birth, travelers, HIV/AIDS, spleen dysfunction, transplant candidates, household communicators, cancer-related immunosuppression, health care professionals. Area under the curve was 0.836 and maximum error was 0.051. Users can make predictions with the following calculator: https://pedrobrasil.shinyapps.io/INDWELL/. The groups with lower seroprevalence should be evaluated more carefully regarding need for hepatitis A virus vaccination even when they seek immunization clinics for other purposes.
DOI: 10.6084/m9.figshare.22268848.v1
title: Hepatitis A seroprevalence among special populations in the Rio de Janeiro Metropolitan Area, Brazil

description: The objectives were to estimate hepatitis A virus seroprevalence in subjects attending to a travel medicine and immunization clinic in Rio de Janeiro, Brazil, and to develop a prediction model for hepatitis A virus seroprevalence. This retrospective research included individuals sequentially from April 2011 to June 2019 at a travel medicine and special population immunization clinic with an anti-hepatitis A virus IgG chemiluminescence result. Participants’ data were verified via electronic medical records. Data were split into development and validation set taking 2018 as the date break. A cross-validated elastic generalized linear model with binomial distribution was performed. In total, 2,944 subjects were analyzed. Hepatitis A virus overall seroprevalence was 67.8%. Health professionals, travelers, and those who had contact with immunocompromised subjects had lower seroprevalence (40%-55%), whereas subjects with chronic conditions (heart, lung, and liver) ranged from 89% to 94%. The retained predictors in the final model were sex, age, year of birth, travelers, HIV/AIDS, spleen dysfunction, transplant candidates, household communicators, cancer-related immunosuppression, health care professionals. Area under the curve was 0.836 and maximum error was 0.051. Users can make predictions with the following calculator: https://pedrobrasil.shinyapps.io/INDWELL/. The groups with lower seroprevalence should be evaluated more carefully regarding need for hepatitis A virus vaccination even when they seek immunization clinics for other purposes.
DOI: 10.6084/m9.figshare.23659366
title: Evaluation of irrigation requirement for the design of an irrigation system using a probabilistic approach for the estimation of evapotranspiration and rainfall

description: ABSTRACT Reference evapotranspiration (ET0) and rainfall are basic variables for estimating the net irrigation depth (NID). The objective of this study was to estimate the NID for designing irrigation systems in Piracicaba, SP, Brazil, using ET0 and rainfall probability distributions. A 30-year ET0 and rainfall dataset (1990-2019) was obtained from the ESALQ/USP weather station. The water balance between ET0 and rainfall indicated July, August, and September as months of higher water deficit. Based on the first-order Markov chain, August presented the highest water deficit. Rainfall and ET0 were estimated on 19 probability levels, and four probability distributions such as normal, log-normal, beta, and mixed gamma were evaluated. The analysis of historical August series using accumulated values in periods of five, ten, or 15 days is recommended for sizing irrigation designs in Piracicaba, SP, Brazil. The log-normal and mixed gamma probability distributions presented the best fit for ET0 and rainfall data, respectively. To reach a crop coefficient Kc = 1 in Piracicaba, SP, Brazil in August, the irrigation system should be designed for an NID of 4.1 mm day-1. The use of mean monthly rainfall and ET0 values for designing irrigation systems underestimates the NID by a mean of 26.6% compared to estimates made at a probability of 75% at five-, ten-, and 15-day intervals because the mean rainfall values occurred with exceedance probabilities of &lt; 36%, and mean ET0 values occurred with non-exceedance probabilities of &lt; 56%.
DOI: 10.6084/m9.figshare.23659366.v1
title: Evaluation of irrigation requirement for the design of an irrigation system using a probabilistic approach for the estimation of evapotranspiration and rainfall

description: ABSTRACT Reference evapotranspiration (ET0) and rainfall are basic variables for estimating the net irrigation depth (NID). The objective of this study was to estimate the NID for designing irrigation systems in Piracicaba, SP, Brazil, using ET0 and rainfall probability distributions. A 30-year ET0 and rainfall dataset (1990-2019) was obtained from the ESALQ/USP weather station. The water balance between ET0 and rainfall indicated July, August, and September as months of higher water deficit. Based on the first-order Markov chain, August presented the highest water deficit. Rainfall and ET0 were estimated on 19 probability levels, and four probability distributions such as normal, log-normal, beta, and mixed gamma were evaluated. The analysis of historical August series using accumulated values in periods of five, ten, or 15 days is recommended for sizing irrigation designs in Piracicaba, SP, Brazil. The log-normal and mixed gamma probability distributions presented the best fit for ET0 and rainfall data, respectively. To reach a crop coefficient Kc = 1 in Piracicaba, SP, Brazil in August, the irrigation system should be designed for an NID of 4.1 mm day-1. The use of mean monthly rainfall and ET0 values for designing irrigation systems underestimates the NID by a mean of 26.6% compared to estimates made at a probability of 75% at five-, ten-, and 15-day intervals because the mean rainfall values occurred with exceedance probabilities of &lt; 36%, and mean ET0 values occurred with non-exceedance probabilities of &lt; 56%.
DOI: 10.6084/m9.figshare.23659369
title: Modification of the government system in Brazil via constitutional amendment: parliamentarism, semi-presidentialism and other models

description: Abstract The article analyzes the constitutional possibility of replacing in Brazil, under the aegis of the 1988 Constitution, the presidential system of government by parliamentary, semi-presidential or other models. Examines the Proposals for Amendment to the Constitution presented to the Chamber of Deputies and the Senate with this object, verifying their eventual incompatibilities with the unamendable clauses. It analyzes what would be the consequence for the States and Municipalities in case of approval of the change in the government system, based on the principle of symmetry enunciated by the Federal Supreme Court. It concludes that, from the constitutional point of view, it is admissible to change the system of government in the country by way of constitutional amendment, provided that a plebiscite is held to previously consult the population about the change.
DOI: 10.6084/m9.figshare.23659369.v1
title: Modification of the government system in Brazil via constitutional amendment: parliamentarism, semi-presidentialism and other models

description: Abstract The article analyzes the constitutional possibility of replacing in Brazil, under the aegis of the 1988 Constitution, the presidential system of government by parliamentary, semi-presidential or other models. Examines the Proposals for Amendment to the Constitution presented to the Chamber of Deputies and the Senate with this object, verifying their eventual incompatibilities with the unamendable clauses. It analyzes what would be the consequence for the States and Municipalities in case of approval of the change in the government system, based on the principle of symmetry enunciated by the Federal Supreme Court. It concludes that, from the constitutional point of view, it is admissible to change the system of government in the country by way of constitutional amendment, provided that a plebiscite is held to previously consult the population about the change.
DOI: 10.6084/m9.figshare.23659367
title: A Modified Radiopropagation Multipath Model for Constant Refractivity Gradient Profiles

description: Abstract This paper presents a radiopropagation algorithm based on a Ray Tracing (RT) technique that combines a modified multipath model for constant refractivity gradient profiles and the Uniform Theory of Diffraction (UTD). A novel formulation is proposed by the authors for calculation and ground-reflection analysis of ray paths depending on atmospheric refractivity. The algorithm introduced herein was evaluated in a mixed scenario and in two more realistic case studies, under conditions of constant refractivity gradient and lossy terrain profiles. Pathloss results are obtained and compared with Parabolic Equation (PE) numerical solution results at 2.0 GHz, 3.5 GHz and 5.4 GHz. In such conditions, the modified radiopropagation multipath algorithm with atmospheric refractivity introduced herein showed satisfactory results.
DOI: 10.6084/m9.figshare.23659367.v1
title: A Modified Radiopropagation Multipath Model for Constant Refractivity Gradient Profiles

description: Abstract This paper presents a radiopropagation algorithm based on a Ray Tracing (RT) technique that combines a modified multipath model for constant refractivity gradient profiles and the Uniform Theory of Diffraction (UTD). A novel formulation is proposed by the authors for calculation and ground-reflection analysis of ray paths depending on atmospheric refractivity. The algorithm introduced herein was evaluated in a mixed scenario and in two more realistic case studies, under conditions of constant refractivity gradient and lossy terrain profiles. Pathloss results are obtained and compared with Parabolic Equation (PE) numerical solution results at 2.0 GHz, 3.5 GHz and 5.4 GHz. In such conditions, the modified radiopropagation multipath algorithm with atmospheric refractivity introduced herein showed satisfactory results.
DOI: 10.6084/m9.figshare.22121285
title: Prevalence of psychoactive substance use by adolescents in public schools in a municipality in the São Paulo Metropolitan Area, Brazil

description: This study aimed to estimate the prevalence of psychoactive substance use by adolescents from public schools. This is a cross-sectional study that used a random sample of adolescents from five public schools located in a municipality in the central-west region of the São Paulo Metropolitan Area, Brazil. Information on demographic, socioeconomic, and drug use was collected using self-report questionnaires. The sample consisted of 1,460 students, 716 (49%) males, aged 10-19 years (13.19±2.04 years). The prevalence of psychoactive substance use in the last month was 51% for analgesics; 48.8% for alcohol; 37.3% for tobacco; 30.8% for tranquilizers; 23.1% for marijuana; 22.6% for anabolic steroids; 21.6% for ecstasy; 15.3% for amphetamines/stimulants; 13.4% for phencyclidine; 12.9% for cocaine/crack; 12.6% for inhalants/solvents; 11.5% for opiates; 11.4% for hallucinogens; and 16.2% for other unclassified drugs. Elementary and middle school students were more likely to consume tobacco (OR = 2.306; 95%CI: 1.733-3.068; p &lt; 0.001), and male students were more likely to consume any type of substance. We identified a high use of psychoactive substances among this study participants, with a higher prevalence among male students.
DOI: 10.6084/m9.figshare.22081574
title: Patterns of abuse of elderly people in Brazil: analysis of notifications

description: This study aimed to describe the characteristics of elderly people abuse notifications by gender and to assess notification patterns according to gender. We analyzed data from the Brazilian Information System for Notificable Diseases (SINAN) in 2017. We carried out a descriptive analysis of victim characteristics, violence, and the probable perpetrator according to gender. Pearson’s χ2 test was used to assess the significance between groups. Then, we verified the main relationships between the studied characteristics and the victim’s gender by simple correspondence analysis (SCA). Thus, 17,311 cases/suspicions of elderly people abuse were notified, corresponding to 7.2% of the total number of violence notifications. Of these victims, 50.4% were white, 42.3% were married, and 17.2% had a disability/disorder; 76.9% occurred at home, 62.8% included physical violence, and 49.5% were cases of repeated violence. Most perpetrators were men (62%), and violence by two or more perpetrators was observed in 62.8% of the cases. SCA evidenced inequalities in older adults’ gender, which proved to be higher among women. Physical violence was the most common among younger and old individuals, whereas neglect/abandonment tended to occur more frequently among the oldest individuals, and was most often committed by daughters. In sum, this study demonstrated evidence of gender-based violence, especially among older adults. Disability proved to be an essential characteristic for neglect/abandonment in older adults. In this context, policies are needed to reduce gender inequalities and implement a care network for older adults who are victims of violence.
DOI: 10.6084/m9.figshare.22081574.v1
title: Patterns of abuse of elderly people in Brazil: analysis of notifications

description: This study aimed to describe the characteristics of elderly people abuse notifications by gender and to assess notification patterns according to gender. We analyzed data from the Brazilian Information System for Notificable Diseases (SINAN) in 2017. We carried out a descriptive analysis of victim characteristics, violence, and the probable perpetrator according to gender. Pearson’s χ2 test was used to assess the significance between groups. Then, we verified the main relationships between the studied characteristics and the victim’s gender by simple correspondence analysis (SCA). Thus, 17,311 cases/suspicions of elderly people abuse were notified, corresponding to 7.2% of the total number of violence notifications. Of these victims, 50.4% were white, 42.3% were married, and 17.2% had a disability/disorder; 76.9% occurred at home, 62.8% included physical violence, and 49.5% were cases of repeated violence. Most perpetrators were men (62%), and violence by two or more perpetrators was observed in 62.8% of the cases. SCA evidenced inequalities in older adults’ gender, which proved to be higher among women. Physical violence was the most common among younger and old individuals, whereas neglect/abandonment tended to occur more frequently among the oldest individuals, and was most often committed by daughters. In sum, this study demonstrated evidence of gender-based violence, especially among older adults. Disability proved to be an essential characteristic for neglect/abandonment in older adults. In this context, policies are needed to reduce gender inequalities and implement a care network for older adults who are victims of violence.
DOI: 10.6084/m9.figshare.22121285.v1
title: Prevalence of psychoactive substance use by adolescents in public schools in a municipality in the São Paulo Metropolitan Area, Brazil

description: This study aimed to estimate the prevalence of psychoactive substance use by adolescents from public schools. This is a cross-sectional study that used a random sample of adolescents from five public schools located in a municipality in the central-west region of the São Paulo Metropolitan Area, Brazil. Information on demographic, socioeconomic, and drug use was collected using self-report questionnaires. The sample consisted of 1,460 students, 716 (49%) males, aged 10-19 years (13.19±2.04 years). The prevalence of psychoactive substance use in the last month was 51% for analgesics; 48.8% for alcohol; 37.3% for tobacco; 30.8% for tranquilizers; 23.1% for marijuana; 22.6% for anabolic steroids; 21.6% for ecstasy; 15.3% for amphetamines/stimulants; 13.4% for phencyclidine; 12.9% for cocaine/crack; 12.6% for inhalants/solvents; 11.5% for opiates; 11.4% for hallucinogens; and 16.2% for other unclassified drugs. Elementary and middle school students were more likely to consume tobacco (OR = 2.306; 95%CI: 1.733-3.068; p &lt; 0.001), and male students were more likely to consume any type of substance. We identified a high use of psychoactive substances among this study participants, with a higher prevalence among male students.
DOI: 10.6084/m9.figshare.22032306
title: Care accessibility and availability for hypertensive patients in primary health care in a remote rural municipality in the state of Amazonas, Brazil, 2019

description: This single-case study aimed to evaluate access the geographic accessibility and availability of primary health care (PHC) in a remote rural municipality in Amazonas Stater, Brazil, to control systemic arterial hypertension. A thematic analysis was conducted to interpret the content of 11 semi-structured interviews with municipal managers, PHC professionals, and hypertensive healthcare users. Geographical accessibility is associated with river mobility, transportation availability, users’ financial travelling condition, and the presence of services near riverine communities, whereas availability to diagnose and monitor hypertensive patients depend on the presence of healthcare providers, medications, and equipment and the integration of PHC with the local health care network. Although access to health is more complex than our research goals, the evaluated dimensions show weaknesses which are exacerbated by a context marked by socio-spatial disparities and absent public policies, compromising the guarantee of individuals’ right to health.