cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16443915
title: Supplementary Material for: Common <b><i>ABCB4</i></b> and <b><i>ABCB11</i></b> Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults

description: <b><i>Introduction:</i></b> Pathogenic mutations in genes encoding the hepatocanalicular transporters <i>ATP8B1</i>, <i>ABCB11</i> and <i>ABCB4</i> are causative for progressive cholestatic liver disease in children. In adults, less severe variants such as the common <i>ABCB4</i> c.711A&gt;T polymorphism have been associated with intrahepatic cholestasis in pregnancy and elevated liver enzymes. Hence, our aim was to study the role of common polymorphisms in adult patients with chronic unexplained cholestasis. <b><i>Methods:</i></b> Screening of outpatients of two university hospitals identified a cohort of 94 patients with chronic cholestasis of unknown origin after thorough exclusion of other causes. Genotyping was performed using TaqMan assays, and frequencies for the <i>ABCB4 rs2109505</i> (c.711A&gt;T), <i>rs1202283</i> (c.504T&gt;C), <i>ABCB11 rs2287622</i> (p.A444V) and <i>rs497692</i> (c.3084A&gt;G) variants of the study cohort were compared to a cohort of 254 healthy controls. <b><i>Results:</i></b> The dominating symptoms of the patients were pruritus and jaundice, though the majority of them did not report symptoms at inclusion. Advanced fibrosis or cirrhosis was present in 11 patients (11.7%) only. Genotyping revealed the presence of the <i>ABCB4</i> c.711A&gt;T risk variant in 79 patients (84%), a frequency that is significantly (<i>p</i> = 0.037) higher than that in controls (71%). The <i>ABCB11 p</i>.A444V variant was also more frequent in cholestatic patients (<i>p</i> = 0.042). <b><i>Conclusion:</i></b> The common <i>ABCB4</i> c.711A&gt;T and <i>ABCB11 p</i>.A444V polymorphisms are more prevalent in adult patients with idiopathic cholestasis than in healthy controls and may therefore represent risk factors for the development of chronic cholestatic liver disease.
DOI: 10.6084/m9.figshare.16443915.v1
title: Supplementary Material for: Common <b><i>ABCB4</i></b> and <b><i>ABCB11</i></b> Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults

description: <b><i>Introduction:</i></b> Pathogenic mutations in genes encoding the hepatocanalicular transporters <i>ATP8B1</i>, <i>ABCB11</i> and <i>ABCB4</i> are causative for progressive cholestatic liver disease in children. In adults, less severe variants such as the common <i>ABCB4</i> c.711A&gt;T polymorphism have been associated with intrahepatic cholestasis in pregnancy and elevated liver enzymes. Hence, our aim was to study the role of common polymorphisms in adult patients with chronic unexplained cholestasis. <b><i>Methods:</i></b> Screening of outpatients of two university hospitals identified a cohort of 94 patients with chronic cholestasis of unknown origin after thorough exclusion of other causes. Genotyping was performed using TaqMan assays, and frequencies for the <i>ABCB4 rs2109505</i> (c.711A&gt;T), <i>rs1202283</i> (c.504T&gt;C), <i>ABCB11 rs2287622</i> (p.A444V) and <i>rs497692</i> (c.3084A&gt;G) variants of the study cohort were compared to a cohort of 254 healthy controls. <b><i>Results:</i></b> The dominating symptoms of the patients were pruritus and jaundice, though the majority of them did not report symptoms at inclusion. Advanced fibrosis or cirrhosis was present in 11 patients (11.7%) only. Genotyping revealed the presence of the <i>ABCB4</i> c.711A&gt;T risk variant in 79 patients (84%), a frequency that is significantly (<i>p</i> = 0.037) higher than that in controls (71%). The <i>ABCB11 p</i>.A444V variant was also more frequent in cholestatic patients (<i>p</i> = 0.042). <b><i>Conclusion:</i></b> The common <i>ABCB4</i> c.711A&gt;T and <i>ABCB11 p</i>.A444V polymorphisms are more prevalent in adult patients with idiopathic cholestasis than in healthy controls and may therefore represent risk factors for the development of chronic cholestatic liver disease.
DOI: 10.6084/m9.figshare.16443906
title: Supplementary Material for: Alveolar Nitric Oxide and Peripheral Oxygen Saturation in Frequent Exacerbators with Asthma: A Pilot Study

description: <b><i>Introduction</i></b>: Asthmatics can experience recurrent exacerbations (AEs), irrespectively of asthma severity. Airway inflammatory monitoring could be fundamental to optimize the asthma management. The present study evaluated whether exhaled NO concentrations in proximal and distal respiratory compartments are different in AE-prone patients in combination with T2 blood biomarkers and resting oxygen saturation (SpO<sub>2</sub>). <b><i>Methods</i></b>: In this observational cross-sectional study, 91 mild-to-severe asthmatics were enrolled. Clinical characteristics, blood and lung function parameters including SpO<sub>2</sub>, and F<sub>E</sub>NO were evaluated. On 50 randomly selected patients, C<sub>A</sub>NO and J<sub>aw</sub>NO were also analyzed. Then, patients were stratified in frequent exacerbators (FEs) or non-frequent exacerbators (nFEs), according to AE frequency in the previous year (phase I). Chart data were re-evaluated through a 12-month follow-up period post exhaled NO measurement to detect occurrence of novel AE (phase II). <b><i>Results</i></b>: FE asthmatics had poorer asthma control and required higher therapeutic intensity (<i>p</i> &lt; 0.05). F<sub>E</sub>NO, C<sub>A</sub>NO, and J<sub>aw</sub>NO were similar between FE and nFE. FE exhibited higher total serum IgE levels and residual volume values but reduced SpO<sub>2</sub> than nFE (<i>p</i> &lt; 0.05); SpO<sub>2</sub>&lt;96.5% characterized the FE patient (odds ratio = 2.94). In phase II, C<sub>A</sub>NO was higher in the group with novel AE at 1-month post-NO measurement (<i>p</i> &lt; 0.05), but not afterward. A higher prevalence of C<sub>A</sub>NO &gt;6 ppb was detected in asthmatics who developed AE within 1 month, suggesting its potential clinical use as biomarker in predicting near-future AE (RR = 11.20). <b><i>Conclusion</i></b>: AE-susceptible asthmatics are characterized by air trapping and distal airway inflammation in conjunction with lower oxygen saturation. C<sub>A</sub>NO and SpO<sub>2</sub> could exert specific roles, respectively, in predicting AE and monitoring FE asthmatics.
DOI: 10.6084/m9.figshare.16443906.v1
title: Supplementary Material for: Alveolar Nitric Oxide and Peripheral Oxygen Saturation in Frequent Exacerbators with Asthma: A Pilot Study

description: <b><i>Introduction</i></b>: Asthmatics can experience recurrent exacerbations (AEs), irrespectively of asthma severity. Airway inflammatory monitoring could be fundamental to optimize the asthma management. The present study evaluated whether exhaled NO concentrations in proximal and distal respiratory compartments are different in AE-prone patients in combination with T2 blood biomarkers and resting oxygen saturation (SpO<sub>2</sub>). <b><i>Methods</i></b>: In this observational cross-sectional study, 91 mild-to-severe asthmatics were enrolled. Clinical characteristics, blood and lung function parameters including SpO<sub>2</sub>, and F<sub>E</sub>NO were evaluated. On 50 randomly selected patients, C<sub>A</sub>NO and J<sub>aw</sub>NO were also analyzed. Then, patients were stratified in frequent exacerbators (FEs) or non-frequent exacerbators (nFEs), according to AE frequency in the previous year (phase I). Chart data were re-evaluated through a 12-month follow-up period post exhaled NO measurement to detect occurrence of novel AE (phase II). <b><i>Results</i></b>: FE asthmatics had poorer asthma control and required higher therapeutic intensity (<i>p</i> &lt; 0.05). F<sub>E</sub>NO, C<sub>A</sub>NO, and J<sub>aw</sub>NO were similar between FE and nFE. FE exhibited higher total serum IgE levels and residual volume values but reduced SpO<sub>2</sub> than nFE (<i>p</i> &lt; 0.05); SpO<sub>2</sub>&lt;96.5% characterized the FE patient (odds ratio = 2.94). In phase II, C<sub>A</sub>NO was higher in the group with novel AE at 1-month post-NO measurement (<i>p</i> &lt; 0.05), but not afterward. A higher prevalence of C<sub>A</sub>NO &gt;6 ppb was detected in asthmatics who developed AE within 1 month, suggesting its potential clinical use as biomarker in predicting near-future AE (RR = 11.20). <b><i>Conclusion</i></b>: AE-susceptible asthmatics are characterized by air trapping and distal airway inflammation in conjunction with lower oxygen saturation. C<sub>A</sub>NO and SpO<sub>2</sub> could exert specific roles, respectively, in predicting AE and monitoring FE asthmatics.
DOI: 10.6084/m9.figshare.16417164.v1
title: Identification and analysis of oil candidate genes reveals the molecular basis of cottonseed oil accumulation in Gossypium hirsutum L.

description: <b>Table S1. </b>Cottonseed oil content of 196 lines intra-specific RIL population.<b></b> <b>Table S2. </b>ANOVA and broad-sense heritability analysis for cottonseed oil content.<b></b> <b>Table S3. </b>QTLs related to cottonseed oil content identified in eight environments. <b>Table S4. </b>832 genes in the five stable QTL regions. <b>Table S5.</b> KEGG pathway enrichment analysis of 832 genes around stable QTLs. <b>Table S6.</b> Genes list identified by BLAST with <i>Arabidopsis thaliana</i> oil-related genes. <b>Table S7. </b>The expression level (FPKM values) of candidate oil genes during developing ovules of <i>G. hirsutum</i> L.<b></b> <b>Table S8. </b>Four transcription factors related to cottonseed lipid content. <b>Table S9. </b>The microRNA-target gene regulatory network of <i>G. hirsutum</i> L. <b>Table S10.</b> The designed primers of genes encoding the key enzymes involved in lipid biosynthesis for qRT-PCR.
DOI: 10.14457/mu.the.1998.231
title: การศึกษาพฤติกรรมส่งเสริมสุขภาพของผู้สูงอายุโรคข้อเข่าเสื่อม
DOI: 10.14457/mu.the.1998.232
title: การศึกษาพฤติกรรมสุขภาพของผู้ป่วยเด็กวัยเรียนโรคหอบหืดที่มีการควบคุมโรคต่างกัน
DOI: 10.14457/mu.the.1998.233
title: การศึกษาความต้องการการดูแลและการได้รับการดูแลจากพยาบาลของผู้ป่วยที่หน่วยพักค้างรอดูอาการ ตึกผู้ป่วยนอกโรงพยาบาลศิริราช
DOI: 10.14457/mu.the.1998.234
title: ปัจจัยที่มีผลต่อกระบวนการตัดสินใจของผู้ติดเฮโรอีนที่เข้ารับการบำบัดรักษา : ศึกษาเฉพาะกรณีวัยรุ่นชายในสถานบำบัดเขตกรุงเทพมหานครและปริมณฑล
DOI: 10.14457/mu.the.1998.235
title: การศึกษาสมดุลย์น้ำเพื่อการออกแบบรูปแบบการปลูกพืช กรณีศึกษา : อ่างเก็บน้ำห้วยโจน ตำบลเขาหินซ้อน อำเภอพนมสารคาม จังหวัดฉะเชิงเทรา
DOI: 10.14457/mu.the.1998.236
title: การศึกษาการดำเนินงานกำจัดมูลฝอยของภาคเอกชน กรณีศึกษา : การจ้างเหมาเพื่อการกลบฝังร่วมกับกรุงเทพมหานคร
DOI: 10.14457/mu.the.1998.237
title: การเปรียบเทียบพฤติกรรมเกี่ยวกับการท่องเที่ยวเชิงอนุรักษ์ของนักท่องเที่ยวที่พักค้างแรมและไม่พักค้างแรม ในอุทยานแห่งชาติแก่งกระจาน
DOI: 10.14457/mu.the.1998.238
title: การสร้างและทดลองใช้คู่มือประกอบการสอน การศึกษานอกสถานที่ เรื่องการอนุรักษ์ทรัพยากรธรรมชาติและสิ่งแวดล้อม สำหรับนักเรียนระดับมัธยมศึกษาตอนต้น
DOI: 10.14457/mu.the.1998.239
title: การมีส่วนร่วมของประชาชนท้องถิ่นในการอนุรักษ์ทรัพยากรชายฝั่ง : กรณีศึกษาอำเภอละงู จังหวัดสตูล
DOI: 10.14457/mu.the.1998.240
title: พฤติกรรมการอนุรักษ์พลังงานของนักเรียนประถมศึกษา โรงเรียนในสังกัดสำนักงานการประถมศึกษากรุงเทพมหานคร
DOI: 10.14457/mu.the.1998.241
title: การศึกษาเปรียบเทียบการผลิตปลาหมึกแห้ง โดยใช้เทคโนโลยีพื้นบ้านและเทคโนโลยีประยุกต์ กรณีศึกษา : การผลิตปลาหมึกแห้ง อำเภอเมืองระยอง จังหวัดระยอง
DOI: 10.14457/mu.the.1998.242
title: การศึกษาการใช้สมการจำแนกกลุ่มในงานสำรวจสถานะสุขภาพเรื่องเบาหวานของประชาชนไทยในเขตอำเภอบ้านโป่ง จังหวัดราชบุรี
DOI: 10.14457/mu.the.1998.243
title: ผลของการบรรเทาปวดแบบไม่ใช้ยาต่อระดับความเจ็บปวด อัตราการเต้นของหัวใจและค่าความอิ่มตัวของออกซิเจนในทารกแรกเกิดที่ได้รับการเจาะเลือดบริเวณส้นเท้า
DOI: 10.14457/mu.the.1998.244
title: ความสัมพันธ์ระหว่างพฤติกรรมการเรียนกับผลสัมฤทธิ์ทางการเรียนวิชาศิลปะกับชีวิตของนักเรียนระดับชั้นมัธยมศึกษาปีที่ 2 โรงเรียนมัธยมศึกษา สังกัดกรมสามัญศึกษา จังหวัดสระบุรี
DOI: 10.14457/mu.the.1998.245
title: ผลการเตรียมความพร้อมต่อพฤติกรรมการเลี้ยงทารกด้วยนมมารดาและสัมพันธภาพระหว่างมารดาและทารกในมารดาที่ได้รับการผ่าตัดเอาทารกออกทางหน้าท้อง
DOI: 10.14457/mu.the.1998.246
title: การพัฒนาระบบผู้เชี่ยวชาญการควบคุมฝุ่นละอองจากโรงงานอุตสาหกรรม
DOI: 10.14457/mu.the.1997.430
title: การประเมินความเสี่ยงเชิงปริมาณของภาระกล้ามเนื้อหลังในพนักงานยกเพลทแบตเตอรี่ภายหลังการปรับปรุงสถานีงาน
DOI: 10.14457/mu.the.1998.247
title: การวิเคราะห์ ออกแบบ และพัฒนาระบบกระแสงานของงานสนับสนุนทุนวิจัย
DOI: 10.14457/mu.the.1998.248
title: ความเป็นพิษของน้ำทิ้งชุบโลหะสังกะสีซึ่งบำบัดด้วยไฮดรอกไซด์ และโพลีอิเล็กโตรไลท์ชนิดต่างๆ ต่อไรแดง
DOI: 10.14457/mu.the.1998.249
title: ความคิดเห็นของประธานกรรมการสุขาภิบาลเกี่ยวกับอำนาจหน้าที่ และการปฏิบัติงานตามพระราชบัญญัติการสาธารณสุข พ.ศ.2535
DOI: 10.14457/mu.the.1998.250
title: ความรู้และการปฏิบัติของผู้ประกอบการตามมาตรการทางกฎหมาย ในการประกอบกิจการสถานที่จำหน่ายอาหาร
DOI: 10.14457/mu.the.1998.251
title: ยาเม็ดคุมกำเนิดกับมะเร็งปากมดลูกชนิด adenocarcinoma
DOI: 10.14457/mu.the.1998.252
title: ผลของการรักษาผู้ป่วยวัณโรคที่มีการติดเชื้อไวรัสเอดส์ที่มารับการรักษา ที่โรงพยาบาลราชบุรี
DOI: 10.14457/mu.the.1998.253
title: ความสัมพันธ์ระหว่างปัจจัยคัดสรรกับการปฏิบัติหน้าที่ตามบทบาทของนักเรียนอาสาสมัครสาธารณสุขในโรงเรียน ชั้นประถมศึกษาปีที่ 5-6 ในโรงเรียนประถมศึกษา สังกัดกรุงเทพมหานคร
DOI: 10.14457/mu.the.1998.254
title: ปัญหา อุปสรรคในการปฏิบัติงานด้านการสืบสวนคดีประทุษร้ายทางเพศของเจ้าหน้าที่ตำรวจฝ่ายสืบสวน สถานีตำรวจในเขตตำรวจภูธรภาค 7
DOI: 10.14457/mu.the.1998.255
title: ปัจจัยที่มีความสัมพันธ์กับการใช้บริการที่คลีนิคนอกเวลาราชการ
DOI: 10.14457/mu.the.1997.431
title: การออกแบบการจัดนิทรรศการเรื่อง "หนังสือสมุดไทย" ณ อาคารเรือนไทย มหาวิทยาลัยมหิดล ศาลายา นครปฐม
DOI: 10.5281/zenodo.5266356
title: KrakN - associated dataset

description: In the upload, an example dataset for KrakN software for concrete crack detection is provided. It is to be used with https://github.com/MatZar01/KrakN repository.
DOI: 10.5281/zenodo.5266355
title: KrakN - associated dataset

description: In the upload, an example dataset for KrakN software for concrete crack detection is provided. It is to be used with https://github.com/MatZar01/KrakN repository.
DOI: 10.6084/m9.figshare.14651286
title: f1000researchdata.sav

description: Raw data of effect of Nigella sativa on M1/M2 level in cigarette smoke wistar.
DOI: 10.6084/m9.figshare.14651286.v1
title: f1000researchdata.sav

description: Raw data of effect of Nigella sativa on M1/M2 level in cigarette smoke wistar.
DOI: 10.15490/fairdomhub.1.datafile.4222.1
title: Luminex data: Pancreatic cancer-Senescene
DOI: 10.5281/zenodo.5235630
title: Seasonal Terrestrial Water Load Modulation of Seismicity at the Southeastern Margin of the Tibetan Plateau Deduced from GNSS and GRACE Data

description: Data Set S1. Focal mechanism solutions of M &gt; 4 earthquakes at the southeastern margin of the Tibetan Plateau. The data set includes 634 solutions of earthquakes M &gt; 4, and the time range is from 2009 to 2017. Data Set S2. The earthquake catalog is used to decluster aftershocks and background events, and the time range is from1st January 2009 to 10th June 2021. This data set includes 260656 events in the study area.
DOI: 10.5281/zenodo.5266382
title: Glacially induced stresses for a simple ice load

description: The zip file contains the input file to run an ABAQUS finite element model to obtain glacially induced stresses and vertical displacement for a simple circular ice load. In addition, the stress tensor and vertical displacement are provided for the upper 17.5 km for every time point and grid point of the model. More details are explained in a README file.
DOI: 10.5281/zenodo.5266381
title: Glacially induced stresses for a simple ice load

description: The zip file contains the input file to run an ABAQUS finite element model to obtain glacially induced stresses and vertical displacement for a simple circular ice load. In addition, the stress tensor and vertical displacement are provided for the upper 17.5 km for every time point and grid point of the model. More details are explained in a README file.
DOI: 10.5281/zenodo.5266322
title: On th

description: These are simulation results from running RAM-SCB and GLOW models. Two simulations were conducted. One uses diffusion coefficients derived based on statistical wave properties ("stat"), and the other uses coefficients from event-specific simultaneous wave properties ("event"). Data include the precipitating electron flux, wave diffusion coefficients, and height profiles of ionospheric electron density.
DOI: 10.5281/zenodo.5146024
title: Implication of Folate Deficiency in CYP2U1 loss of function

description: Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenic mechanisms remains sparse and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 gene, loss of which is known to be involved in a complex form of these diseases in Humans. We showed that this model partially recapitulated the clinical and biochemical phenotypes of patients. Using electron microscopy, lipidomic, and proteomic studies, we identified vitamin B2 as a substrate of the CYP2U1 enzyme, as well as coenzyme Q, neopterin, and interferon-alpha levels as putative biomarkers in mouse and in fluids obtained from the largest series of CYP2U1- mutated patients reported so far. We also confirmed brain calcifications as a potential biomarker in patients. Our results suggest that CYP2U1 deficiency disrupts mitochondrial function and impacts proper neurodevelopment, which could be prevented by folate supplementation in our mouse model, followed by a neurodegenerative process altering multiple neuronal and extra neuronal tissues.
description: Lipidomic and proteomic analysis
DOI: 10.5281/zenodo.5266395
title: Effectiveness of a multicomponent intervention consisting of education and feedback on reducing benzodiazepine prescriptions by general practitioners: BENZORED hybrid type I cluster randomized controlled trial.

description: Complete dataset variables: GP_ID<br> Health_District<br> Health_District_name<br> PHC_ID<br> PHC_ID_name<br> Arm<br> DHD_Baseline<br> DHD_12m<br> PercentageBZD_baseline<br> PercentageBZD_12m<br> PercentageBZD_baseline_age65<br> PercentageBZD_12m_age65
DOI: 10.5281/zenodo.5266396
title: On th

description: These are simulation results from running RAM-SCB and GLOW models. Two simulations were conducted. One uses diffusion coefficients derived based on statistical wave properties ("stat"), and the other uses coefficients from event-specific simultaneous wave properties ("event"). Data include the precipitating electron flux, wave diffusion coefficients, and height profiles of ionospheric electron density.
DOI: 10.6084/m9.figshare.16443954
title: Supplementary Material for: The Role of Hepatic Arterial Infusion Chemotherapy in the Treatment of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> The main aim of this study was to investigate comprehensively the clinical effect of hepatic arterial infusion chemotherapy (HAIC) on patients suffering from hepatocellular carcinoma (HCC). <b><i>Methods:</i></b> The following electronic databases were searched for eligible articles published from inception to July 2020: PubMed, Web of Science, Embase, and Cochrane Library. The main final indicators were overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). <b><i>Results:</i></b> A total of 26 studies entailing 4,506 cases were included for a meta-analysis. The results showed that HAIC could improve advanced HCC patients’ OS (HR, 0.49; 95% CI: 0.37–0.61) and PFS (HR, 0.52; 95% CI: 0.36–0.68). Remarkably, compared with Japan (HR, 0.58) and Korea (HR, 0.54), for the unresectable HCC patients, the HAIC group achieved higher efficacy on OS than the control group in China (HR, 0.24). The resectable HCC patients, who received HAIC adjuvant chemotherapy, exhibited favorable prognosis for OS (HR, 0.58; 95% CI: 0.27–0.88) and DFS (HR, 0.49; 95% CI: 0.31–0.68). <b><i>Conclusion:</i></b> HAIC improved long-term survival for both resectable and unresectable HCC patients in comparison with other therapies. However, the clinical effect of HAIC needs to be ascertained by large-scale well-designed studies.
DOI: 10.6084/m9.figshare.16444086
title: Supplementary Material for: Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute Kidney Injury Cell Model

description: <b><i>Background:</i></b> We intended to investigate the function of circular RNA RasGEF domain family member 1B (circ_RASGEF1B) in lipopolysaccharide (LPS)-induced septic acute kidney injury (AKI) cell model and its associated mechanism. <b><i>Methods:</i></b> TCMK-1 cells were exposed to 10 μg/mL LPS for 24 h to establish a septic AKI cell model. Mice were intraperitoneally injected with 10 mg/kg LPS to establish a septic AKI mice model. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot assay were used to measure RNA and protein expression, respectively. Cell viability and apoptosis were assessed by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and flow cytometry. Cell inflammatory response was analyzed using enzyme-linked immunosorbent assay. Dual-luciferase reporter assay was conducted to confirm the predicted target relationship between microRNA-146a-5p (miR-146a-5p) and circ_RASGEF1B or pyruvate dehydrogenase kinase 1 (Pdk1). <b><i>Results:</i></b> The circ_RASGEF1B level was upregulated in LPS-induced TCMK-1 cells and septic AKI mice models. LPS exposure reduced cell viability and promoted cell apoptosis and inflammatory response partly by upregulating circ_RASGEF1B. Circ_RASGEF1B bound to miR-146a-5p and miR-146a-5p interference partly overturned circ_RASGEF1B silencing-mediated effects in LPS-induced TCMK-1 cells. Pdk1 was a target of miR-146a-5p, and Pdk1 accumulation partly counteracted miR-146a-5p-induced influences in TCMK-1 cells upon LPS stimulation. <b><i>Conclusion:</i></b> Circ_RASGEF1B promoted LPS-induced apoptosis and inflammatory response in renal tubular epithelial cells partly by upregulating Pdk1 via acting as miR-146a-5p sponge.
DOI: 10.24396/ordar-85
title: Table S3 - Magma-Mush Interactions in the Lower Oceanic crust: Insights from Atlantis Bank Layered Series (Southwest Indian Ridge)

description: In-situ major element contents of plagioclases (Pl), clinopyroxenes (Cpx) and olivines (Ol) quantified by EPMA at the Laboratoire Magmas et Volcans (Clermont-Ferrand, France) with a Cameca SX100 equipped with four wavelength dispersive X-ray spectrometers. Analyses for all minerals were performed with a 15 kV accelerating potential and a focused beam using a 15 nA beam current. On-peak and background counting times were 10 or 20 s (see details and calibration standards for each element at the top of the table). Calibration standards are provided at the end of the table.