cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12845469.v1
title: Prognostic performance of proteomic testing in advanced non-small cell lung cancer: a systematic literature review and meta-analysis

description: Timely assessment of patient-specific prognosis is critical to oncology care involving a shared decision-making approach, but clinical prognostic factors traditionally used in NSCLC have limitations. We examine a proteomic test to address these limitations. This study examines the prognostic performance of the VeriStrat blood-based proteomic test that measures the inflammatory disease state of patients with advanced NSCLC. A systematic literature review (SLR) was performed, yielding cohorts in which the hazard ratio (HR) was reported for overall survival (OS) of patients with VeriStrat Poor (VSPoor) test results versus VeriStrat Good (VSGood). A study-level meta-analysis of OS HRs was performed in subgroups defined by lines of therapy and treatment regimens. Twenty-four cohorts met SLR criteria. Meta-analyses in five subgroups (first-line platinum-based chemotherapy, second-line single-agent chemotherapy, first-line EGFR-tyrosine kinase inhibitor (TKI) therapy, and second- and higher-line TKI therapy, and best supportive care) resulted in statistically significant (<i>p</i> ≤ .001) summary effect sizes for OS HRs of 0.42, 0.54, 0.41, 0.52, and 0.50, respectively, indicating increased OS by about two-fold for patients who test VSGood. No significant heterogeneity was seen in any subgroup (<i>p</i> &gt; .05). Advanced NSCLC patients classified VSGood have significantly longer OS than those classified VSPoor. The summary effect size for OS HRs around 0.4–0.5 indicates that the expected median survival of those with a VSGood classification is approximately 2–2.5 times as long as those with VSPoor. The robust prognostic performance of the VeriStrat test across various lines of therapy and treatment regimens has clinical implications for treatment shared decision-making and potential for novel treatment strategies.
DOI: 10.6084/m9.figshare.12871744.v1
title: Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin

description: There are significant differences in costs and effectiveness among the second-line treatment options for type 2 diabetes (T2DM). We aimed to evaluate the cost-effectiveness of the second-line anti-diabetic therapy in T2DM patients inadequately controlled on metformin (MET) in Taiwan from the perspective of the National Health Insurance (NHI). The Cardiff T2DM model was used to predict the occurrence of mortality, diabetes-related complications, and drug adverse events. Five second-line treatments were selected for the analysis: sodium-glucose cotransporter 2 inhibitors (SGLT-2-i), glucagon-like peptide-1 receptor agonists (GLP-1-RA), dipeptidyl peptidase-4 inhibitor (DPP-4-i), sulfonylurea (SU), and insulin (INS). Treatment efficacy data were obtained from meta-analyses and randomized clinical trials, whereas cost data were derived from the NHI databases. The analysis found that SU + MET (DPP-4-i as triple therapy) had the lowest cost, and SU + MET (SGLT-2-i as triple therapy) was associated with a mean incremental benefit of 0.47 quality-adjusted life years (QALYs) at an incremental cost of NT$2769, resulting in an incremental cost-effectiveness ratio (ICER) of NT$5840/QALY. Compared to their next less costly strategies, SGLT-2-i + MET (SU as triple therapy) and SGLT-2-i + MET (DPP-4-i as triple therapy) had ICER values of NT$63,170/QALY and NT$64,090/QALY, respectively. These results were fairly robust to extensive sensitivity analyses, but were relatively sensitive to baseline HbA1c, HbA1c threshold, and utilities. The addition of either SU or SGLT-2-i to MET was found to be cost-effective, using the 2019 forecast for GDP per capita of Taiwan (NT$770,770) as the willingness to pay (WTP) threshold.
DOI: 10.6084/m9.figshare.12871744
title: Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin

description: There are significant differences in costs and effectiveness among the second-line treatment options for type 2 diabetes (T2DM). We aimed to evaluate the cost-effectiveness of the second-line anti-diabetic therapy in T2DM patients inadequately controlled on metformin (MET) in Taiwan from the perspective of the National Health Insurance (NHI). The Cardiff T2DM model was used to predict the occurrence of mortality, diabetes-related complications, and drug adverse events. Five second-line treatments were selected for the analysis: sodium-glucose cotransporter 2 inhibitors (SGLT-2-i), glucagon-like peptide-1 receptor agonists (GLP-1-RA), dipeptidyl peptidase-4 inhibitor (DPP-4-i), sulfonylurea (SU), and insulin (INS). Treatment efficacy data were obtained from meta-analyses and randomized clinical trials, whereas cost data were derived from the NHI databases. The analysis found that SU + MET (DPP-4-i as triple therapy) had the lowest cost, and SU + MET (SGLT-2-i as triple therapy) was associated with a mean incremental benefit of 0.47 quality-adjusted life years (QALYs) at an incremental cost of NT$2769, resulting in an incremental cost-effectiveness ratio (ICER) of NT$5840/QALY. Compared to their next less costly strategies, SGLT-2-i + MET (SU as triple therapy) and SGLT-2-i + MET (DPP-4-i as triple therapy) had ICER values of NT$63,170/QALY and NT$64,090/QALY, respectively. These results were fairly robust to extensive sensitivity analyses, but were relatively sensitive to baseline HbA1c, HbA1c threshold, and utilities. The addition of either SU or SGLT-2-i to MET was found to be cost-effective, using the 2019 forecast for GDP per capita of Taiwan (NT$770,770) as the willingness to pay (WTP) threshold.
DOI: 10.15468/cdarx7
title: World List of Priapulida

description: This global marine species list is part of the World Register of Marine Species database, which aims to provide the most authoritative list of names of all marine species globally. Data have been contributed to the Catalogue of Life via the WoRMS, hosted by the Flanders Marine Institute (VLIZ).
DOI: 10.5281/zenodo.3969658
title: DELETE

description: DELETE
DOI: 10.15468/47wdkb
title: World List of Mystacocarida

description: This global marine species list is part of the World Register of Marine Species database, which aims to provide the most authoritative list of names of all marine species globally. Data have been contributed to the Catalogue of Life via the WoRMS, hosted by the Flanders Marine Institute (VLIZ).
DOI: 10.6084/m9.figshare.14259992
title: Supplementary Material for: Variants in <b><i>ACE2</i></b> and <b><i>TMPRSS2</i></b> Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects

description: It is plausible that variants in the <i>ACE2</i> and <i>TMPRSS2</i> genes might contribute to variation in COVID-19 severity and that these could explain why some people become very unwell whereas most do not. Exome sequence data was obtained for 49,953 UK Biobank subjects, of whom 82 had tested positive for SARS-CoV-2 and could be presumed to have severe disease. A weighted burden analysis was carried out using SCOREASSOC to determine whether there were differences between these cases and the other sequenced subjects in the overall burden of rare, damaging variants in <i>ACE2</i> or <i>TMPRSS2</i>. There were no statistically significant differences in weighted burden scores between cases and controls for either gene. There were no individual DNA sequence variants with a markedly different frequency between cases and controls. Whether there are small effects on severity, or whether there might be rare variants with major effect sizes, would require studies in much larger samples. Genetic variants affecting the structure and function of the ACE2 and TMPRSS2 proteins are not the main explanation for why some people develop severe symptoms in response to infection with SARS-CoV-2. This research was conducted using the UK Biobank Resource.
DOI: 10.15468/gr2hwn
title: World List of Scleractinia

description: This global marine species list is part of the World Register of Marine Species database, which aims to provide the most authoritative list of names of all marine species globally. Data have been contributed to the Catalogue of Life via the WoRMS, hosted by the Flanders Marine Institute (VLIZ).
DOI: 10.15468/d69drr
title: World List of Tanaidacea

description: This global marine species list is part of the World Register of Marine Species database, which aims to provide the most authoritative list of names of all marine species globally. Data have been contributed to the Catalogue of Life via the WoRMS, hosted by the Flanders Marine Institute (VLIZ).
DOI: 10.17870/bathspa.12263228
title: Very Clear Instructions - 300-word Statement

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine. <br>This item contains a 300-word Statement about the project.
DOI: 10.17870/bathspa.12263228.v1
title: Very Clear Instructions - 300-word Statement

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine. <br>This item contains a 300-word Statement about the project.
DOI: 10.17870/bathspa.12263774
title: Very Clear Instructions - Research Timeline and Research Questions

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine. <br>This item contains the Research Timeline and Research Questions for the project.
DOI: 10.17870/bathspa.12263774.v1
title: Very Clear Instructions - Research Timeline and Research Questions

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine. <br>This item contains the Research Timeline and Research Questions for the project.
DOI: 10.17870/bathspa.12263789
title: Very Clear Instructions - Performance - video extracts

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine.<br><br>This item contains video extracts of the performance held Off-site at The Polygon Gallery, North Vancouver on Friday, April 20, 2018.<br><br>Videos: John Wood and Paul Harrison; used with permission.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.12263789.v1
title: Very Clear Instructions - Performance - video extracts

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine.<br><br>This item contains video extracts of the performance held Off-site at The Polygon Gallery, North Vancouver on Friday, April 20, 2018.<br><br>Videos: John Wood and Paul Harrison; used with permission.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.12280487.v1
title: Very Clear Instructions - Performance Photos

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine.<br><br>This item contains evidence relating to the performance held Off-site at The Polygon Gallery, North Vancouver on Friday, April 20, 2018.<br><br>Photographs: <i>Four Eyes Portraits</i>, used with permission.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.12280487
title: Very Clear Instructions - Performance Photos

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine.<br><br>This item contains evidence relating to the performance held Off-site at The Polygon Gallery, North Vancouver on Friday, April 20, 2018.<br><br>Photographs: <i>Four Eyes Portraits</i>, used with permission.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.12263792
title: Very Clear Instructions - Methods and Process I

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine.<br><br>This item contains evidence of the methods and process of creating the performance, which was held Off-site at The Polygon Gallery, North Vancouver on Friday, April 20, 2018.<br><br>The evidence consists of notes made during the development of <i>Very Clear Instructions</i>.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.12263792.v1
title: Very Clear Instructions - Methods and Process I

description: <i>Very Clear Instructions</i> is a collaborative, cross-disciplinary piece which saw John Wood and Paul Harrison working with the Vancouver Contemporary Art Gallery (CAG) and Ballet BC. The performance is rooted in a distillation of everyday gestures and routine.<br><br>This item contains evidence of the methods and process of creating the performance, which was held Off-site at The Polygon Gallery, North Vancouver on Friday, April 20, 2018.<br><br>The evidence consists of notes made during the development of <i>Very Clear Instructions</i>.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.6084/m9.figshare.12156564
title: Surface pollen distribution in alpine zone of the higher Himalaya: a case study from the Kalla glacier valley, India

description: In order to understand the relationship between modern pollen spectra and vegetation, we analysed 20 surface sediment samples collected from the alpine zone of Kalla Bank glacier valley, Dhauliganga Basin, India covering an elevational stretch of c. 3600 to 5000 m asl and vegetation zones like the alpine scrub, alpine meadow and alpine barren. This study also provides insights into the vertical pollen transport along the elevational gradient of the glacier valley. Numerical analyses such as cluster analysis (CA), discriminant analysis (DA) and detrended correspondence analysis (DCA) are used to explore and discuss the modern pollen deposition patterns in the alpine settings. Despite the inconsistencies observed between modern vegetation and surface palynoassemblages, a good agreement is noticed between CA and DA classifications and DCA ordination results which reveal signature of upslope wind transport. High percentages of pine, cedar, alder and birch pollen grains in the above tree-line surface pollen assemblages are indicative of their upslope wind transport from a lower elevation. The inconsistencies may be attributed to the differential pollen representation between species, differential flowering and pollination of herbaceous taxa. The present study suggests altitude and monsoonal winds might be the two most influential factors that attributed changes in the surface palynoassemblages of the alpine vegetation in the Kalla Bank glacier (Kunti-Banar) valley. Therefore, while interpreting the fossil pollen spectra from any high altitude mountainous zone, long-distance pollen transport should always be taken into account, especially for anemophilous plant taxa.
DOI: 10.6084/m9.figshare.12852804
title: Tracking diversity and evolutionary pathways of Lebanese oak taxa through plastome analyses

description: The aim of this study is to better understand the phylogeography and evolution of the Lebanese oaks and to assess the convergence between their morpho-ecological and molecular characteristics. We investigated DNA sequence variation in four plastid markers (<i>TrnH-psbA, ycf1</i>, trnK-<i>matK</i> and <i>PetD</i>) of the seven species (three sections) occurring in Lebanon: <i>Q. calliprinos, Q. infectoria, Q. kotschyana, Q. cedrorum, Q. cerris, Q. look</i>, and <i>Q. ithaburensis</i>, in addition to <i>Q. libani</i> and <i>Q. cerris</i> from Syria, and possible hybrids. Among the four markers, the <i>TrnH-psbA</i> and <i>trnK-matK</i> loci resulted in the best-resolved genealogies. <i>Quercus calliprinos</i> haplotypes clearly belong to the west Asian-eastern Mediterranean ‘WAHEA’ lineage. Sect. <i>Cerris</i> haplotypes are derived variants of the central Mediterranean ‘Cerris-Ilex’ lineage. Sect. <i>Quercus</i> haplotypes were less differentiated and in close connection with the Caucasian primary refugium of white oaks. Despite the low species-level resolution, a gradient in genetic diversity linked to the ecological plasticity of the sampled species was observed. A close relationship of <i>Q. look</i> with <i>Q. cerris</i> is confirmed. <i>Quercus kotschyana</i> seems an ancient stock of closely related and disjunct oak of sect. <i>Quercus</i>. Finally, our results confirm the relevance of the Levant region as an important biogeographical crossroad between continents, and its key role in stimulating diversification and preservation of ancient genepools. Important areas in Lebanon that should be taken into consideration in future conservation strategies are highlighted, to ensure a wider genetic potential of local oak species to face the current climate change.
DOI: 10.6084/m9.figshare.12156564.v1
title: Surface pollen distribution in alpine zone of the higher Himalaya: a case study from the Kalla glacier valley, India

description: In order to understand the relationship between modern pollen spectra and vegetation, we analysed 20 surface sediment samples collected from the alpine zone of Kalla Bank glacier valley, Dhauliganga Basin, India covering an elevational stretch of c. 3600 to 5000 m asl and vegetation zones like the alpine scrub, alpine meadow and alpine barren. This study also provides insights into the vertical pollen transport along the elevational gradient of the glacier valley. Numerical analyses such as cluster analysis (CA), discriminant analysis (DA) and detrended correspondence analysis (DCA) are used to explore and discuss the modern pollen deposition patterns in the alpine settings. Despite the inconsistencies observed between modern vegetation and surface palynoassemblages, a good agreement is noticed between CA and DA classifications and DCA ordination results which reveal signature of upslope wind transport. High percentages of pine, cedar, alder and birch pollen grains in the above tree-line surface pollen assemblages are indicative of their upslope wind transport from a lower elevation. The inconsistencies may be attributed to the differential pollen representation between species, differential flowering and pollination of herbaceous taxa. The present study suggests altitude and monsoonal winds might be the two most influential factors that attributed changes in the surface palynoassemblages of the alpine vegetation in the Kalla Bank glacier (Kunti-Banar) valley. Therefore, while interpreting the fossil pollen spectra from any high altitude mountainous zone, long-distance pollen transport should always be taken into account, especially for anemophilous plant taxa.
DOI: 10.6084/m9.figshare.12852804.v1
title: Tracking diversity and evolutionary pathways of Lebanese oak taxa through plastome analyses

description: The aim of this study is to better understand the phylogeography and evolution of the Lebanese oaks and to assess the convergence between their morpho-ecological and molecular characteristics. We investigated DNA sequence variation in four plastid markers (<i>TrnH-psbA, ycf1</i>, trnK-<i>matK</i> and <i>PetD</i>) of the seven species (three sections) occurring in Lebanon: <i>Q. calliprinos, Q. infectoria, Q. kotschyana, Q. cedrorum, Q. cerris, Q. look</i>, and <i>Q. ithaburensis</i>, in addition to <i>Q. libani</i> and <i>Q. cerris</i> from Syria, and possible hybrids. Among the four markers, the <i>TrnH-psbA</i> and <i>trnK-matK</i> loci resulted in the best-resolved genealogies. <i>Quercus calliprinos</i> haplotypes clearly belong to the west Asian-eastern Mediterranean ‘WAHEA’ lineage. Sect. <i>Cerris</i> haplotypes are derived variants of the central Mediterranean ‘Cerris-Ilex’ lineage. Sect. <i>Quercus</i> haplotypes were less differentiated and in close connection with the Caucasian primary refugium of white oaks. Despite the low species-level resolution, a gradient in genetic diversity linked to the ecological plasticity of the sampled species was observed. A close relationship of <i>Q. look</i> with <i>Q. cerris</i> is confirmed. <i>Quercus kotschyana</i> seems an ancient stock of closely related and disjunct oak of sect. <i>Quercus</i>. Finally, our results confirm the relevance of the Levant region as an important biogeographical crossroad between continents, and its key role in stimulating diversification and preservation of ancient genepools. Important areas in Lebanon that should be taken into consideration in future conservation strategies are highlighted, to ensure a wider genetic potential of local oak species to face the current climate change.
DOI: 10.24385/44225
title: The role of the written element in composition PhDs in the UK: qualitative and quantitative survey data
DOI: 10.24385/44229
title: Memory, Migration and Music: Oral Histories from Lincolnshire's Eastern European migrant population