cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7422641.v1
title: Relationship of statins and other cholesterol-lowering medications and risk of amyotrophic lateral sclerosis in the US elderly

description: <i>Objective</i>: Statins are commonly prescribed drugs that have been inconsistently associated with amyotrophic lateral sclerosis (ALS) risk. We examined associations between ALS risk and overall statin use, statin categories based on lipophilicity and other cholesterol-lowering medications, in Medicare beneficiaries. <i>Methods</i>: In <b>t</b>his nation-wide population-based case-control study, 10,450 Medicare participants (ages 66–89 years) diagnosed with ALS, using Medicare Parts A and B claims, between 1 January 2008 and 31 December 2014, were frequency-matched to 104,500 controls on age, sex, and selection year. Odds ratios (ORs) for the association between statins and ALS were estimated using logistic regression models. Covariates included dyslipidemia, other comorbidities, age, sex, race, proxies for smoking and obesity, Medicare use, and indicators of socioeconomic status. Statin use derived from Medicare Part D claims. Non–statin cholesterol–lowering drugs were evaluated as comparison drugs. <i>Results</i>: ALS risk was reduced with statin use (OR = 0.87 (95% confidence interval (CI) = 0.83–0.91)). While risk was unrelated to three cholesterol-lowering medications (nitrates, bile acid sequestrants, and ezetimibe), it was associated with fibrates (OR = 0.88 (95% CI = 0.80–0.97)). Risk for lipophilic statins was slightly lower than for other statins. ALS risk was lower in all statin categories for dyslipidemic individuals, but only lipophilic statins were associated with lower risk in non-dyslipidemic individuals and demonstrated an inverse trend with duration. <i>Conclusions</i>: Our findings suggest that statins are associated with lower ALS risk and offer new evidence that fibrates may be related to lower risk. However, we were unable to fully adjust for smoking and body mass index.
DOI: 10.6084/m9.figshare.7422617
title: Congruence, national context and trust in European institutions

description: How can we explain the recent decline of trust in representative institutions of the EU in many of its Member States? This article presents evidence supporting the congruence hypothesis, according to which citizens have been extrapolating their increasing distrust in national institutions to the EU institutions. We also find that these contagion effects are produced by citizens’ evaluations of national governments. Furthermore, we show that these spillover effects from the national to the EU level tend to be stronger in situations of economic recession and political crisis. The only counterbalance to this contagion comes from citizens’ positive evaluation of EU performance. We test these general arguments based on a twofold panel analysis of the Spanish case, a country that has suffered a remarkable deterioration of political trust in a context of profound economic and political crisis, by analysing data from a micro-level panel study and 28 pooled surveys from the Eurobarometer between 1999 and 2015.
DOI: 10.6084/m9.figshare.7422620
title: Rawdataset.xlsx

description: Plasma levels of the inflammatory and endothelial markers in women with von Willebrand disease and healthy controls.
DOI: 10.7284/113025
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1314 using a Garmin GPS-17HVS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422620.v1
title: Rawdataset.xlsx

description: Plasma levels of the inflammatory and endothelial markers in women with von Willebrand disease and healthy controls.
DOI: 10.6084/m9.figshare.7422617.v2
title: Congruence, national context and trust in European institutions

description: How can we explain the recent decline of trust in representative institutions of the EU in many of its Member States? This article presents evidence supporting the congruence hypothesis, according to which citizens have been extrapolating their increasing distrust in national institutions to the EU institutions. We also find that these contagion effects are produced by citizens’ evaluations of national governments. Furthermore, we show that these spillover effects from the national to the EU level tend to be stronger in situations of economic recession and political crisis. The only counterbalance to this contagion comes from citizens’ positive evaluation of EU performance. We test these general arguments based on a twofold panel analysis of the Spanish case, a country that has suffered a remarkable deterioration of political trust in a context of profound economic and political crisis, by analysing data from a micro-level panel study and 28 pooled surveys from the Eurobarometer between 1999 and 2015.
DOI: 10.7284/113026
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1314 using a Ashtech ADU2 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422617.v1
title: Congruence, national context and trust in European institutions

description: How can we explain the recent decline of trust in representative institutions of the EU in many of its Member States? This article presents evidence supporting the congruence hypothesis, according to which citizens have been extrapolating their increasing distrust in national institutions to the EU institutions. We also find that these contagion effects are produced by citizens’ evaluations of national governments. Furthermore, we show that these spillover effects from the national to the EU level tend to be stronger in situations of economic recession and political crisis. The only counterbalance to this contagion comes from citizens’ positive evaluation of EU performance. We test these general arguments based on a twofold panel analysis of the Spanish case, a country that has suffered a remarkable deterioration of political trust in a context of profound economic and political crisis, by analysing data from a micro-level panel study and 28 pooled surveys from the Eurobarometer between 1999 and 2015.
DOI: 10.7284/113027
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1314 using a Furuno GP-90D instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422593
title: Additional file 4: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S4. Differentially expressed genes in response to salt plus ozone (based on log fold change, with FDRâ
DOI: 10.6084/m9.figshare.7422587
title: Additional file 2: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S2. Differentially expressed genes in response to salt (based on log fold change, with FDRâ
DOI: 10.6084/m9.figshare.7422590
title: Additional file 3: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S3. Differentially expressed genes in response to ozone (based on absolute log fold change, with FDRâ
DOI: 10.6084/m9.figshare.7422593.v1
title: Additional file 4: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S4. Differentially expressed genes in response to salt plus ozone (based on log fold change, with FDRâ
DOI: 10.7284/113024
title: Gyrocompass data collected during research cruise NH1314 using a Sperry MK-37 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422587.v1
title: Additional file 2: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S2. Differentially expressed genes in response to salt (based on log fold change, with FDRâ
DOI: 10.6084/m9.figshare.7422590.v1
title: Additional file 3: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S3. Differentially expressed genes in response to ozone (based on absolute log fold change, with FDRâ
DOI: 10.6084/m9.figshare.7422584
title: Additional file 1: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S1. Blastn comparison between de novo assembly transcriptome (Q. ilex) and OCV3_91K reference transcriptome (Q. robur and Q. petraea, Lesur et al. 2015) [35]. (XLSX 6828 kb)
DOI: 10.7284/113021
title: Meteorological Station data collected during research cruise NH1314 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422584.v1
title: Additional file 1: of How Quercus ilex L. saplings face combined salt and ozone stress: a transcriptome analysis

description: Table S1. Blastn comparison between de novo assembly transcriptome (Q. ilex) and OCV3_91K reference transcriptome (Q. robur and Q. petraea, Lesur et al. 2015) [35]. (XLSX 6828 kb)
DOI: 10.6084/m9.figshare.7422569
title: MOESM4 of Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

description: Additional file 4. Results of KEGG enrichment analysis and GO analysis. Excel file reporting the detailed results obtained with STRING for KEGG enrichment analysis, Biological process, Molecular function and Cellular component.
DOI: 10.7284/113028
title: Meteorological Station data collected during research cruise NH1314 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422563
title: MOESM3 of Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

description: Additional file 3. Protein identification details and differential proteomic results based on label-free quantitation. Excel file reporting: the list of all proteins identified in each sample with the detailed data for coverage, proteins, unique peptides, and PSMs; the average NSAF value of each sheep protein in all experimental samples; the average NSAF value of each MAP protein in all experimental samples; and the complete list of all differential proteins detected in PTB vs K, PTB1 vs K, and PTB2 vs K, with the respective RSC, FC, beta-binomial p value, and beta-binomial p value after Benjaminiâ Hochberg correction.
DOI: 10.6084/m9.figshare.7422569.v1
title: MOESM4 of Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

description: Additional file 4. Results of KEGG enrichment analysis and GO analysis. Excel file reporting the detailed results obtained with STRING for KEGG enrichment analysis, Biological process, Molecular function and Cellular component.
DOI: 10.6084/m9.figshare.7422563.v1
title: MOESM3 of Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis

description: Additional file 3. Protein identification details and differential proteomic results based on label-free quantitation. Excel file reporting: the list of all proteins identified in each sample with the detailed data for coverage, proteins, unique peptides, and PSMs; the average NSAF value of each sheep protein in all experimental samples; the average NSAF value of each MAP protein in all experimental samples; and the complete list of all differential proteins detected in PTB vs K, PTB1 vs K, and PTB2 vs K, with the respective RSC, FC, beta-binomial p value, and beta-binomial p value after Benjaminiâ Hochberg correction.
DOI: 10.7284/113022
title: Winch data collected during research cruise NH1314 using a Markey DUSH-5 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422554
title: Additional file 5: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S4. RNA sequencing results (XLSX 51 kb)
DOI: 10.7284/113030
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise NH1315 using a Hawaii UHDAS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422554.v1
title: Additional file 5: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S4. RNA sequencing results (XLSX 51 kb)
DOI: 10.7284/113029
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise NH1315 using a Sea-Bird SBE-911+ instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422542
title: Additional file 3: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S3. List of cases (XLSX 66 kb)
DOI: 10.7284/113033
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1315 using a Furuno GP-150 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422542.v1
title: Additional file 3: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S3. List of cases (XLSX 66 kb)
DOI: 10.6084/m9.figshare.7422527
title: Additional file 2: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S2. Candidate probes in screening set for pyrosequencing assay (XLSX 11 kb)
DOI: 10.7284/113035
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1315 using a Garmin GPS-17HVS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422524
title: Additional file 8: of Homologous recombination changes the context of Cytochrome b transcription in the mitochondrial genome of Silene vulgaris KRA

description: Data Set S1. Coverage Genes. Data Set S2. Coverage ORFs. Data Set S3. Coverage Intergenic. Data Set S4. Editing Sites. Data Set S5. Editing Comparison. Data Set S6. Primers. (XLSX 93 kb)
DOI: 10.6084/m9.figshare.7422524.v1
title: Additional file 8: of Homologous recombination changes the context of Cytochrome b transcription in the mitochondrial genome of Silene vulgaris KRA

description: Data Set S1. Coverage Genes. Data Set S2. Coverage ORFs. Data Set S3. Coverage Intergenic. Data Set S4. Editing Sites. Data Set S5. Editing Comparison. Data Set S6. Primers. (XLSX 93 kb)
DOI: 10.6084/m9.figshare.7422527.v1
title: Additional file 2: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S2. Candidate probes in screening set for pyrosequencing assay (XLSX 11 kb)
DOI: 10.7284/113036
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1315 using a Ashtech ADU2 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422509
title: Additional file 1: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S1. Primer sequences and pyrosequencing assays (XLSX 14 kb)
DOI: 10.7284/113037
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1315 using a Furuno GP-90D instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422509.v1
title: Additional file 1: of Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

description: Table S1. Primer sequences and pyrosequencing assays (XLSX 14 kb)
DOI: 10.7284/113034
title: Gyrocompass data collected during research cruise NH1315 using a Sperry MK-37 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113031
title: Meteorological Station data collected during research cruise NH1315 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113038
title: Meteorological Station data collected during research cruise NH1315 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113032
title: Winch data collected during research cruise NH1315 using a Markey DUSH-5 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422461
title: Additional file 2: of Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity

description: Figure S1. MHC Class-I profile in K562, CAKI-1, SN12C, A498 and 786-O cells. The expression of MHC-I was evaluated in RCC target cells by flow cytometry (FITC-conjugated major histocompatibility complex (MHC) class I–specific antibody (IgG2a, W6/32, CBL139F, Cymbus Biotech, Hants, UK). Figure S2. NKs from VHL-MUT-RCC patients display higher cytotoxicity toward human renal cancer cells VHL mutated A498 and 786-O. NK cell function was evaluated through CD107a cell-surface expression in response to ex vivo stimulation with K562, CAKI-1 (VHL-WT), A498 and 786-O (VHL-MUT) cells. Degranulation (CD107a) was evaluated after gating on CD3-CD56+ cells. CD107a+NK cells in 5 VHL-MUT (A) and 9 VHL-WT (B) RCC patients versus K562, CAKI-1, A498 and 786-O renal cell lines. Figure S3. NCAM-1, DNAM-1, FcγRIIIa, NKp44 and NKG2D are slightly overexpressed in VHL-MUT RCC tumors. RNA from 34 RCC tumors (17 VHL-WT and 17 VHL-MUT). Transcript levels are presented as mean±SEM. Statistical significance was calculated by unpaired Student t test (p &lt; 0.05 ). Figure S4. NCAM-1, DNAM-1, FcγRIIIa, NKp30, NKp46, NKp44, NKG2D expression are upregulated in VHL-MUT tumors as compared to VHL-WT tumors. 17 VHL-MUT (A) and 17 VHL-WT (B). RT-PCR was performed on total RNA isolated from 34 tumors and relative peritumoral tissues (17 VHL-WT and 17 VHL-MUT). Relative gene expression levels were normalized to GUSB. Statistical significance was calculated by unpaired Student t test (p &lt; 0.05). Figure S5. Expression of DNAM-1 ligand (PVR) in CAKI-1 and A498 cell lines. The expression of PVR (CD155) was evaluated in RCC target cells by flow cytometry (PE anti-human CD155/PVR, ( clone SKIL.4, Biolegend, Cat No 337609). (ZIP 561 kb)
DOI: 10.6084/m9.figshare.7422461.v1
title: Additional file 2: of Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity

description: Figure S1. MHC Class-I profile in K562, CAKI-1, SN12C, A498 and 786-O cells. The expression of MHC-I was evaluated in RCC target cells by flow cytometry (FITC-conjugated major histocompatibility complex (MHC) class I–specific antibody (IgG2a, W6/32, CBL139F, Cymbus Biotech, Hants, UK). Figure S2. NKs from VHL-MUT-RCC patients display higher cytotoxicity toward human renal cancer cells VHL mutated A498 and 786-O. NK cell function was evaluated through CD107a cell-surface expression in response to ex vivo stimulation with K562, CAKI-1 (VHL-WT), A498 and 786-O (VHL-MUT) cells. Degranulation (CD107a) was evaluated after gating on CD3-CD56+ cells. CD107a+NK cells in 5 VHL-MUT (A) and 9 VHL-WT (B) RCC patients versus K562, CAKI-1, A498 and 786-O renal cell lines. Figure S3. NCAM-1, DNAM-1, FcγRIIIa, NKp44 and NKG2D are slightly overexpressed in VHL-MUT RCC tumors. RNA from 34 RCC tumors (17 VHL-WT and 17 VHL-MUT). Transcript levels are presented as mean±SEM. Statistical significance was calculated by unpaired Student t test (p &lt; 0.05 ). Figure S4. NCAM-1, DNAM-1, FcγRIIIa, NKp30, NKp46, NKp44, NKG2D expression are upregulated in VHL-MUT tumors as compared to VHL-WT tumors. 17 VHL-MUT (A) and 17 VHL-WT (B). RT-PCR was performed on total RNA isolated from 34 tumors and relative peritumoral tissues (17 VHL-WT and 17 VHL-MUT). Relative gene expression levels were normalized to GUSB. Statistical significance was calculated by unpaired Student t test (p &lt; 0.05). Figure S5. Expression of DNAM-1 ligand (PVR) in CAKI-1 and A498 cell lines. The expression of PVR (CD155) was evaluated in RCC target cells by flow cytometry (PE anti-human CD155/PVR, ( clone SKIL.4, Biolegend, Cat No 337609). (ZIP 561 kb)
DOI: 10.7284/113039
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise NH1316 using a Hawaii UHDAS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/113042
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1316 using a Furuno GP-150 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422443
title: Additional file 5: of Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells

description: Table S5–1. GO Biological Process annotations for genes altered only in MIA PaCa-2 by AbE treatment. Table S5–2. GO Biological Process annotations for genes altered only in PCI-35 by AbE treatment. Table S5–3. GO Biological Process annotations for genes altered only in PK-8 by AbE treatment. (XLS 996 kb)
DOI: 10.6084/m9.figshare.7422443.v1
title: Additional file 5: of Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells

description: Table S5–1. GO Biological Process annotations for genes altered only in MIA PaCa-2 by AbE treatment. Table S5–2. GO Biological Process annotations for genes altered only in PCI-35 by AbE treatment. Table S5–3. GO Biological Process annotations for genes altered only in PK-8 by AbE treatment. (XLS 996 kb)
DOI: 10.7284/113044
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1316 using a Garmin GPS-17HVS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7422434
title: Additional file 4: of Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells

description: Table S4â 1. Overrepresentation test using REACTOME. Table S4â 2. Genes overrepresented by REACTOME analysis. (XLS 31 kb)
DOI: 10.6084/m9.figshare.7422434.v1
title: Additional file 4: of Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells

description: Table S4â 1. Overrepresentation test using REACTOME. Table S4â 2. Genes overrepresented by REACTOME analysis. (XLS 31 kb)