cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20299722.v1
title: Late Carboniferous extension-related magmatism in the southwestern Alxa block of NW China: geochronology, geochemistry, and tectonic implications

description: Whether the northern margin of the North China Craton (NCC) was a continental arc or in a lithospheric extensional setting during the Carboniferous is the primary divergence among different tectonic models about the terminal evolutionary history of the southeastern Central Asian Orogenic Belt (CAOB). The Alxa block is the western segment of the northern NCC and contiguous to the southeastern CAOB, and therefore the tectonic setting of the Carboniferous magmatic intrusions in this block can shed light on this controversy. In this contribution, new zircon U–Pb ages, elemental geochemistry, and Sr-Nd isotopes are presented for thirteen Late Carboniferous (~318–300 Ma) magmatic intrusions in the southwestern Alxa block. Among them, seven calc-alkaline I-type granites and one aluminous A2-type granite were probably generated by the partial melting and crystallization differentiation of various crustal sources (perhaps including earlier orogenic materials) under different temperature conditions. Four quartz diorites and one hornblende gabbro may be the partial melts of subduction-modified basaltic lower crust sources and sub-continental lithospheric mantle sources, respectively. According to the integration of the new results and regional geological correlations, the Alxa block and the southeastern CAOB were most likely in a uniform tectonic regime during the Carboniferous. At that time, this region was characterized by the lithospheric extension-related magmatic rock associations, the increasing mantle inputs over time, the clockwise P–T paths of high temperature-low pressure metamorphic rocks, and the transgression sedimentary sequences. All these lines of evidence suggest an intra-continental lithospheric extensional setting rather than a continental arc setting for the southeastern CAOB during the Carboniferous.
DOI: 10.34683/sr583
title: StoneRounds Case: SR583
title: AR Stargardt Disease

description: StoneRounds Case SR583 was diagnosed with AR Stargardt Disease likely caused by mutations in the gene: ABCA4.
DOI: 10.6084/m9.figshare.14532273
title: Additional file 3 of Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors

description: Additional file 3.
DOI: 10.6084/m9.figshare.14532270
title: Additional file 2 of Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors

description: Additional file 2.
DOI: 10.6084/m9.figshare.14532270.v1
title: Additional file 2 of Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors

description: Additional file 2.
DOI: 10.6084/m9.figshare.25213583
title: RepEnTools - mm39 RMSK.gtf

description: mm39 RMSK.gtf for RepEnToolsOnly suitable for mm39Original bed12 file made with repeat masker (www.repeatmasker.org), downloaded from UCSC Table Browser (Karolchik, 2004). Last updated:<b> </b>2020-07-30The repeat masker (RMSK) annotation file employed<b> </b>in <i>RepEnTools</i> is adjusted to correctly represent the information on the repeat element.
DOI: 10.7266/n7qv3jkx
title: Expendable bathythermograph (XBT) data from Northern Gulf of Mexico September 10, 2016
DOI: 10.6084/m9.figshare.11393019
title: <i>C9orf72</i> and <i>smcr8</i> mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis

description: How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in <i>C9orf72</i> is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we found that <i>c9orf72</i> and <i>smcr8</i> double-knockout (dKO) mice exhibit similar but more severe immune defects than the individual <i>knockouts</i>. In <i>c9orf72</i> or <i>smcr8</i> mutant macrophages, lysosomal degradation and exocytosis were impaired due to the disruption of autolysosome acidification. As a result of impaired lysosomal degradation, MTOR protein was aberrantly increased, resulting in MTORC1 signaling overactivation. Inhibition of hyperactive MTORC1 partially rescued macrophage dysfunction, splenomegaly and lymphadenopathy in <i>c9orf72</i> or <i>smcr8</i> mutant mice. Pharmacological inhibition of lysosomal degradation upregulated MTOR protein and MTORC1 signaling in differentiated wild-type macrophages, which resemble phenotypes in KO mice. In contrast, <i>C9orf72</i> or <i>Smcr8</i> depletion in proliferating macrophages decreased MTORC1 signaling. Our studies causatively link C9orf72-SMCR8’s cellular functions in lysosomal degradation, exocytosis, and MTORC1 signaling with their organism-level immune regulation, suggesting cell state (proliferation vs. differentiation)-dependent regulation of MTOR signaling via lysosomes.<b>Abbreviations</b>: ALS: amyotrophic lateral sclerosis; ATG13: autophagy related 13; BMDMs: bone marrow-derived macrophages; BafA<sub>1</sub>: bafilomycin A<sub>1</sub>; C9orf72: C9orf72, member of C9orf72-SMCR8 complex; CD68: CD68 antigen; ConA: concanamycin A; dKO: double knockout; DENN: differentially expressed in normal and neoplastic cells; FTD: frontotemporal dementia; GEF: guanine nucleotide exchange factor; IFNB1: interferon beta 1, fibroblast; IFNG: interferon gamma; IL1B/IL-1β: interleukin 1 beta; IL6: interleukin 6; iPSCs: induced pluripotent stem cells; LAMP1: lysosomal-associated membrane protein 1; LPOs: LAMP1-positive organelles; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; LPS: lipopolysaccharide; MTORC1: mechanistic target of rapamycin kinase complex 1; MEFs: mouse embryonic fibroblasts; MNs: motor neurons; NOS2/iNOS: nitric oxide synthase 2, inducible; RAN: repeat-associated non-AUG; RB1CC1/FIP200: RB1-inducible coiled-coil 1; RPS6/S6: ribosomal protein S6; RPS6KB1/S6K1: ribosomal protein S6 kinase, polypeptide 1; SMCR8: Smith-Magenis syndrome chromosome region, candidate 8; SQSTM1/p62: sequestosome 1; TFEB: transcription factor EB; TNF: tumor necrosis factor; TSC1: TSC complex subunit 1; ULK1: unc-51 like kinase 1; v-ATPase: vacuolar-type H⁺-translocating ATPase
DOI: 10.6084/m9.figshare.11393019.v2
title: <i>C9orf72</i> and <i>smcr8</i> mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis

description: How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in <i>C9orf72</i> is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we found that <i>c9orf72</i> and <i>smcr8</i> double-knockout (dKO) mice exhibit similar but more severe immune defects than the individual <i>knockouts</i>. In <i>c9orf72</i> or <i>smcr8</i> mutant macrophages, lysosomal degradation and exocytosis were impaired due to the disruption of autolysosome acidification. As a result of impaired lysosomal degradation, MTOR protein was aberrantly increased, resulting in MTORC1 signaling overactivation. Inhibition of hyperactive MTORC1 partially rescued macrophage dysfunction, splenomegaly and lymphadenopathy in <i>c9orf72</i> or <i>smcr8</i> mutant mice. Pharmacological inhibition of lysosomal degradation upregulated MTOR protein and MTORC1 signaling in differentiated wild-type macrophages, which resemble phenotypes in KO mice. In contrast, <i>C9orf72</i> or <i>Smcr8</i> depletion in proliferating macrophages decreased MTORC1 signaling. Our studies causatively link C9orf72-SMCR8’s cellular functions in lysosomal degradation, exocytosis, and MTORC1 signaling with their organism-level immune regulation, suggesting cell state (proliferation vs. differentiation)-dependent regulation of MTOR signaling via lysosomes.<b>Abbreviations</b>: ALS: amyotrophic lateral sclerosis; ATG13: autophagy related 13; BMDMs: bone marrow-derived macrophages; BafA<sub>1</sub>: bafilomycin A<sub>1</sub>; C9orf72: C9orf72, member of C9orf72-SMCR8 complex; CD68: CD68 antigen; ConA: concanamycin A; dKO: double knockout; DENN: differentially expressed in normal and neoplastic cells; FTD: frontotemporal dementia; GEF: guanine nucleotide exchange factor; IFNB1: interferon beta 1, fibroblast; IFNG: interferon gamma; IL1B/IL-1β: interleukin 1 beta; IL6: interleukin 6; iPSCs: induced pluripotent stem cells; LAMP1: lysosomal-associated membrane protein 1; LPOs: LAMP1-positive organelles; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; LPS: lipopolysaccharide; MTORC1: mechanistic target of rapamycin kinase complex 1; MEFs: mouse embryonic fibroblasts; MNs: motor neurons; NOS2/iNOS: nitric oxide synthase 2, inducible; RAN: repeat-associated non-AUG; RB1CC1/FIP200: RB1-inducible coiled-coil 1; RPS6/S6: ribosomal protein S6; RPS6KB1/S6K1: ribosomal protein S6 kinase, polypeptide 1; SMCR8: Smith-Magenis syndrome chromosome region, candidate 8; SQSTM1/p62: sequestosome 1; TFEB: transcription factor EB; TNF: tumor necrosis factor; TSC1: TSC complex subunit 1; ULK1: unc-51 like kinase 1; v-ATPase: vacuolar-type H⁺-translocating ATPase
DOI: 10.6084/m9.figshare.11393019.v1
title: <i>c9orf72</i> and <i>smcr8</i> mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis

description: How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in <i>C9orf72</i> is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we found that <i>c9orf72</i> and <i>smcr8</i> double-knockout (dKO) mice exhibit similar but more severe immune defects than the individual <i>knockouts</i>. In <i>c9orf72</i> or <i>smcr8</i> mutant macrophages, lysosomal degradation and exocytosis were impaired due to the disruption of autolysosome acidification. As a result of impaired lysosomal degradation, MTOR protein was aberrantly increased, resulting in MTORC1 signaling overactivation. Inhibition of hyperactive MTORC1 partially rescued macrophage dysfunction, splenomegaly and lymphadenopathy in <i>c9orf72</i> or <i>smcr8</i> mutant mice. Pharmacological inhibition of lysosomal degradation upregulated MTOR protein and MTORC1 signaling in differentiated wild-type macrophages, which resemble phenotypes in KO mice. In contrast, <i>C9orf72</i> or <i>Smcr8</i> depletion in proliferating macrophages decreased MTORC1 signaling. Our studies causatively link C9orf72-SMCR8’s cellular functions in lysosomal degradation, exocytosis, and MTORC1 signaling with their organism-level immune regulation, suggesting cell state (proliferation vs. differentiation)-dependent regulation of MTOR signaling via lysosomes.
DOI: 10.17028/rd.lboro.25251064.v1
title: Supplementary information files for Does social-norm messaging influence expected satiety and ideal portion-size selection?

description: © the authors, CC-BY NC ND 4.0Supplementary files for article Does social-norm messaging influence expected satiety and ideal portion-size selection?A person's perception of how long a food will stave off hunger (expected satiety) and the ideal amount to consume (ideal portion size) are both influenced by food-to-mealtime norms. Here, we examine whether social norms can modulate this effect, in three experimental studies. In study 1 (n = 235) participants were exposed to a social norm suggesting most people enjoyed consuming pasta for breakfast. There was a main effect of food-to-mealtime congruence for expected satiety and ideal portion size (p &lt; 0.001) – participants selected a smaller portion of pasta for breakfast (vs. lunch) – but there were no other main effects/interactions (p ≥ 0.15). Study 2 (n = 200) followed the same approach as study 1, but sought to examine whether the typical volume of food consumed at breakfast and lunch needed to be controlled. Again, there was a main effect of congruence (the same pattern) (p ≤ 0.02) but no other main effects/interactions (p ≥ 0.73). Study 3 (n = 208) followed the same approach as study 2, but the social-norm message was changed to suggest that most people who eat pasta for breakfast found it effectively reduced their hunger. Again, there was a main effect of congruence (the same pattern) (p &lt; 0.001) but no other main effects/interaction (p ≥ 0.26). These studies provide further evidence for the food-to-mealtime effect, but do not provide any evidence that a single, simple social-norm statement can modulate expected satiety or ideal portion size, or interact with the food-to-mealtime effect.
DOI: 10.6084/m9.figshare.21354495
title: Delocalization State-Induced Selective Bond Breaking for Efficient Methanol Electrosynthesis from CO2

description: Source data of XRD, .hkl file from 3D electron diffraction, and electrolysis data.
DOI: 10.6084/m9.figshare.15056821
title: Identification of microRNA transcriptome throughout the lifespan of yak (<i>Bos grunniens</i>) corpus luteum

description: The corpus luteum (CL) is a temporary organ that plays a critical role for female fertility by maintaining the estrous cycle. MicroRNA (miRNA) is a class of non-coding RNAs involved in various biological processes. However, there exists limited knowledge of the role of miRNA in yak CL. In this study, we used high-throughput sequencing to study the transcriptome dynamics of miRNA in yak early (eCL), middle (mCL) and late-stage CL (lCL). A total of 6,730 miRNAs were identified, including 5,766 known and 964 novels miRNAs. Three miRNAs, including bta-miR-126-3p, bta-miR-143 and bta-miR-148a, exhibited the highest expressions in yak CLs of all the three stages. Most of the miRNAs were 20–24 nt in length and the peak was at 22 nt. Besides, most miRNAs with different lengths displayed significant uracil preference at the 5'-end. Furthermore, 1,067, 280 and 112 differentially expressed (DE) miRNAs were found in eCL vs. mCL, mCL vs. lCL, and eCL vs. lCL, respectively. Most of the DE miRNAs were down-regulated in the eCL vs. mCL and eCL vs. lCL groups, and up-regulated in the mCL vs. lCL group. A total of 18,904 target genes were identified, with 18,843 annotated. Pathway enrichment analysis of the DE miRNAs target genes illustrated that the most enriched cellular process in each group included pathways in cancer, PI3K-Akt pathway, endocytosis, and focal adhesion. A total of 20 putative target genes in 47 DE miRNAs were identified to be closely associated with the formation, function or regression of CL. Three DE miRNAs, including bta-miR-11972, novel-miR-619 and novel-miR-153, were proved to directly bind to the 3'-UTR of their predicated target mRNAs, including <i>CDK4</i>, <i>HSD17B1</i> and <i>MAP1LC3C</i>, respectively. Both of these DE miRNAs and their target mRNAs exhibited dynamic expression profiles across the lifespan of yak CL. This study presents a general basis for understanding of the regulation of miRNA on yak CL and also provides a novel genetic resource for future analysis of the gene network during the estrous cycle in the yak.
DOI: 10.6084/m9.figshare.6668456.v1
title: XPS raw data from Highly efficient triazolone/metal ion/polydopamine/MCM-41 sustained release system with pH sensitive for pesticide delivery

description: MCM-41 was prepared through the sol–gel method and encapsulated by polydopamine (PDA) before coordinated with metal ion to form a highly efficient sustained release system (M-PDA–MCM-41) for triazolone delivery. The characterization results confirmed the existence of the coordination bond between the PDA layer and triazolone through the bridge effect from metal ion, which enhanced the interaction between PDA–MCM-41 and triazolone. The adsorption capacity (AC) of Fe-PDA–MCM-41 increased up to 173 mg g<sup>–1</sup>, which was 160% more than that of MCM-41. The sustained release performance of M-PDA–MCM-41 in different pH values was investigated. Under the conditions of pH ≤7, the release speed of triazolone increased with pH decreasing. Whereas its release speed in the weak base condition was slower than in the neutral condition. Therefore, the as-synthesized system showed significant pH-sensitivity in the sustained release process, indicating that the sustained release system can be well stored in the neutral or basic environment and activated in the acid environment. Their sustained release curves described by Korsmeyer–Peppas equation at pH 7 showed the same behaviour, indicating that PDA decoration or metal ion coordination only increases the steric hindrance and the interaction between carrier and triazolone instead of changing the original structure of the pure MCM material in accordance with XRD and BET analysis results.
DOI: 10.15468/wtrkrt
title: Red list of flora and fauna of Poltava region of Ukraine

description: The checklist consists of species of animals and plants that are rare or endangered in the territory of the Poltava region of Ukraine. The checklist was implemented by the decision of the eighteenth session of the fourth convocation of the Poltava Regional Council dated March 23, 2005.
DOI: 10.6084/m9.figshare.7717073.v1
title: Additional file 2: of Integrative analysis based on survival associated co-expression gene modules for predicting Neuroblastoma patientsâ survival time

description: Table S2. Enrichment analysis for unique co-expression modules which are enriched with different biological processes, molecular functions, or specific pathways related to cancer physiology or to neurological functions (XLS 39 kb)
DOI: 10.6084/m9.figshare.14532612
title: Additional file 2 of Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

description: Additional file 2 A list of potential therapeutic targets for Alzheimer’s disease.
DOI: 10.6084/m9.figshare.14532623.v1
title: Additional file 2 of High-resolution age-specific mapping of the two-week illness prevalence rate based on the National Health Services Survey and geostatistical analysis: a case study in Guangdong province, China

description: Additional file 2. The R codes of the study.
DOI: 10.6084/m9.figshare.7717115
title: Additional file 2: of Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury

description: The RNA sequencing results showed genes were significantly altered by overexpression of miR-126-5p in SAECs. Human small airway epithelial cells (SAECs) were transfected with either control miRNA or miR-126-5p mimic for 48â h, and total RNA was isolated for RNA sequencing analysis. Genes significantly altered by miR-126-5p were listed. (XLSX 433 kb)
DOI: 10.6084/m9.figshare.7716986.v1
title: Additional file 1: of Positive or negative? The shell alters the relationship among behavioral defense strategy, energy metabolic levels and antioxidant capacity in freshwater turtles

description: Data and correlation analysis for all parameters used in the present study. (XLSX 34 kb)
DOI: 10.6084/m9.figshare.7192925
title: Selection of marker peptides from casein phosphopeptide and application for quantification in infant formula

description: Casein phosphopeptides (CPPs) have been used worldwide as a nutritional supplement. However, the peptide components have been unknown; as a consequence, few quantification methods of CPP in infant formula were reported. This study introduced a quantification method based on peptide marker and corresponding peptide selection strategy using a simplified model with four commercial types of CPP. The peptides from four commercial CPPs were first identified. Due to the great variety of CPPs, two marker selection strategies were adopted: on one hand, universal marker peptide VLPVPQK can be used for the quantification of all four commercial CPPs, if the CPP can be obtained as a standard. On the other hand, the specific marker peptide LYQEPVLGPV can be used for identification and quantification of commercial CPP type K content in infant formula with a fixed calculation factor. In the simplified model, the combination use of the two markers can meet most of the requirements of CPP analysis in infant formula. The method validation revealed that this was suitable for the routine analysis laboratories without proteomics backgrounds. This selection strategy was suggested for the large-scale marker peptide selection with all commercial CPPs, which can give a comprehensive solution of CPP quantification in infant formula. <b>Abbreviations:</b> CPP: Casein phosphopeptides; LC: Liquid chromatography; TQMS: Triple quadrupole mass spectrometry; MRM: Multiple reaction monitoring; RSD: Relative standard deviation; <i>L</i>*: [<sup>13</sup>C<sub>6</sub>, <sup>15</sup>N]-leucine; SSSEE: Peptides sequence of serine-serine-serine-glutamic acid-glutamic acid
DOI: 10.6084/m9.figshare.14526029
title: Additional file 1 of Interaction between early-life pet exposure and methylation pattern of ADAM33 on allergic rhinitis among children aged 3–6 years in China

description: Additional file 1: Table S1. Description of data: twenty-five AR genes retrieved from Phenopedia database and references to the original publication reporting their association to AR.
DOI: 10.6084/m9.figshare.14532623
title: Additional file 2 of High-resolution age-specific mapping of the two-week illness prevalence rate based on the National Health Services Survey and geostatistical analysis: a case study in Guangdong province, China

description: Additional file 2. The R codes of the study.
DOI: 10.18112/openneuro.ds004952.v1.0.4
title: Novel Reading
DOI: 10.6084/m9.figshare.7717280
title: MOESM2 of Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke

description: Additional file 2: S2. Differentially expressed genes involved in stroke.
DOI: 10.6084/m9.figshare.7717295.v1
title: MOESM4 of Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke

description: Additional file 4: S4. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis among the AF- and stroke-related differentially expressed genes.
DOI: 10.6084/m9.figshare.6668459
title: FT-IR raw data from Highly efficient triazolone/metal ion/polydopamine/MCM-41 sustained release system with pH sensitive for pesticide delivery

description: MCM-41 was prepared through the sol–gel method and encapsulated by polydopamine (PDA) before coordinated with metal ion to form a highly efficient sustained release system (M-PDA–MCM-41) for triazolone delivery. The characterization results confirmed the existence of the coordination bond between the PDA layer and triazolone through the bridge effect from metal ion, which enhanced the interaction between PDA–MCM-41 and triazolone. The adsorption capacity (AC) of Fe-PDA–MCM-41 increased up to 173 mg g<sup>–1</sup>, which was 160% more than that of MCM-41. The sustained release performance of M-PDA–MCM-41 in different pH values was investigated. Under the conditions of pH ≤7, the release speed of triazolone increased with pH decreasing. Whereas its release speed in the weak base condition was slower than in the neutral condition. Therefore, the as-synthesized system showed significant pH-sensitivity in the sustained release process, indicating that the sustained release system can be well stored in the neutral or basic environment and activated in the acid environment. Their sustained release curves described by Korsmeyer–Peppas equation at pH 7 showed the same behaviour, indicating that PDA decoration or metal ion coordination only increases the steric hindrance and the interaction between carrier and triazolone instead of changing the original structure of the pure MCM material in accordance with XRD and BET analysis results.