cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2z321xm
title: BindingDB Entry 50049290: A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.

description: Small molecule binding data for protein A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), Matrix metalloproteinase (1 and 13), Matrix metalloproteinase (2 and 3), Matrix metalloproteinase 12, Matrix metalloproteinase 14, and Matrix metalloproteinase 2/9, Uniprot O75173, P08253, P08254, P39900, P45452, P50281, and Q9UNA0
DOI: 10.15468/s9ivoh
title: Description de trois nouvelles espèces d ° Amblyopone avec quelques notes biogéographiques sur le genre au Brésil (Formicidae, Ponerinae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Lacau, Sébastien, Delabie, Jacques H. C. (2002): Description de trois nouvelles espèces d ° Amblyopone avec quelques notes biogéographiques sur le genre au Brésil (Formicidae, Ponerinae). Bulletin de la Société entomologíque de France 107 (1): 33-41, DOI: http://doi.org/10.5281/zenodo.3576308
DOI: 10.7270/q21v5h87
title: BindingDB Entry 50049297: The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A

description: Small molecule binding data for protein Adenosine receptor, Adenosine receptor A1/Alpha-2A adrenergic receptor, and Adenosine receptors; A1 & A2a, Uniprot P0DMS8, P29274, P29275, and P30542
DOI: 10.7270/q25m680z
title: BindingDB Entry 50049296: Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 2C, Dopamine D2 receptor and serotonin 2a receptor, and Serotonin receptor (2b and 2c), Uniprot P28335 and P41595
DOI: 10.7270/q298898h
title: BindingDB Entry 50049295: The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

description: Small molecule binding data for protein Glutamate [NMDA] receptor subunit epsilon 2/zeta 1, Glutamate [NMDA] receptor subunit epsilon 3/zeta 1, and Ionotropic glutamate receptor NMDA 1/2D, Uniprot P35439, Q00960, Q00961, and Q62645
DOI: 10.7270/q2d220xw
title: BindingDB Entry 50049302: Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.

description: Small molecule binding data for protein BRD4/HDAC1, DNA (cytosine-5)-methyltransferase 1 (DNMT1), Histone acetyltransferase KAT2A/KAT2B, Histone-arginine methyltransferase CARM1, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Nuclear SET domain-containing protein 1 (NSD1), PRMT5/MEP50 Enzyme, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 3, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 8, Protein arginine methyltransferase 7 (PRMT7), and SET domain-containing protein 7/9 (Set7/9), Uniprot O14744, O60678, O60885, P26358, Q86X55, Q8TEK3, Q8WTS6, Q92830, Q96L73, Q96LA8, Q99873, Q9BQA1, Q9NR22, and Q9NVM4
DOI: 10.7270/q2f191zc
title: BindingDB Entry 50049294: Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

description: Small molecule binding data for protein BRAF/CRAF and RAF serine/threonine protein kinase, Uniprot P15056
DOI: 10.7270/q2js9spd
title: BindingDB Entry 50049293: Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRa) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).

description: Small molecule binding data for protein Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor, Potassium voltage-gated channel subfamily H member 2, Proto-oncogene tyrosine-protein kinase receptor Ret , Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta), Vascular endothelial growth factor receptor 1, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot L7RSL3, P07333, P07949, P09619, P10721, P11362, P16234, P17948, P35916, P35968, P36888, and Q12809
DOI: 10.7270/q2pk0jdp
title: BindingDB Entry 50049292: Synthetic Approaches to the New Drugs Approved During 2015.

description: Small molecule binding data for protein D(3) dopamine receptor, Dipeptidyl peptidase 4, and Dopamine receptor D2L/neurotensin receptor NTS1, Uniprot P14416, P27487, and P35462
DOI: 10.7270/q2sb481g
title: BindingDB Entry 50049299: Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.

description: Small molecule binding data for protein Acid ceramidase (AC), Uniprot Q13510
DOI: 10.7270/q2x350rs
title: BindingDB Entry 50049298: Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10), Human diphtheria toxin-like ADP-ribosyltransferase (ARTD4 or PARP4), Human diphtheria toxin-like ADP-ribosyltransferase (ARTD8 or PARP14), Mono [ADP-ribose] polymerase PARP16, Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon, PARP 1, 2 and 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphodiesterase 3 and 5 (PDE3 and PDE5), Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 11, Serotonin 3 (5-HT3) receptor, Solute carrier organic anion transporter family member 1B1 (OATP1B1), and Tankyrase 1/2, Uniprot O95271, P02708, P09874, P40989, P46098, P48736, Q14432, Q460N5, Q53GL7, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, and Q9Y6L6
DOI: 10.7270/q20v8g2z
title: BindingDB Entry 50049305: Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization.

description: Small molecule binding data for protein Interleukin-15 and Interleukin-2 (IL-2), Uniprot P40933 and P60568
DOI: 10.7270/q24m96tq
title: BindingDB Entry 50049304: 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.

description: Small molecule binding data for protein Potassium voltage-gated channel subfamily H member 2, Uniprot Q12809
DOI: 10.7270/q27d2xd7
title: BindingDB Entry 50049311: Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.

description: Small molecule binding data for protein Lactoperoxidase (LPO) and Myeloperoxidase, Uniprot P05164 and P80025
DOI: 10.7270/q28c9zhm
title: BindingDB Entry 50049303: a-Conotoxin [S9A]TxID Potently Discriminates betweena3ß4 anda6/a3ß4 Nicotinic Acetylcholine Receptors.

description: Small molecule binding data for protein Neuronal acetylcholine receptor, Neuronal acetylcholine receptor protein alpha-2/beta-4 subunit, Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit, Neuronal acetylcholine receptor protein alpha-4/beta-4 subunit, Nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta, Nicotinic acetylcholine receptor alpha6/alpha3/beta4, and Nicotinic acetylcholine receptor alpha9/alpha10, Uniprot P02716, P04756, P04757, P09483, P09690, P12389, P12390, P12392, P20782, P43143, P43144, Q05941, and Q9JLB5
DOI: 10.7270/q2c53p3h
title: BindingDB Entry 50049310: Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

description: Small molecule binding data for protein Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Macrophage colony-stimulating factor 1 receptor, Pancreatic endoplasmic reticulum kinase (PERK), SRC, Serine/threonine-protein kinase TAO2, Tyrosine-protein kinase BMX, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lyn, VEGF-receptor 2 and Fibroblast growth factor receptor 1, VEGF-receptor 2 and Fibroblast growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot P07333, P07948, P11362, P21802, P22455, P22607, P35916, P35968, P51451, P51813, P52333, Q9NZJ5, and Q9UL54
DOI: 10.7270/q2ht2rmg
title: BindingDB Entry 50049301: Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

description: Small molecule binding data for protein Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protein kinase ABL1, Uniprot P00519 and P12931
DOI: 10.7270/q2mk6g5c
title: BindingDB Entry 50049308: Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.

description: Small molecule binding data for protein Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a), Dopamine D2 receptor and serotonin 2a receptor, Potassium voltage-gated channel subfamily H member 2, Serotonin receptor (2b and 2c), and Serotonin receptor 2a and 2c (5HT2A and 5HT2C), Uniprot P08909, P14842, P28335, P41595, and Q12809
DOI: 10.7270/q2nk3h9r
title: BindingDB Entry 50049300: Synthesis of 8-Substituted Analogues of Cyclic ADP-4-Thioribose and Their Unexpected Identification as Ca

description: Small molecule binding data for protein Ryanodine receptor, Uniprot Q8TA74
DOI: 10.7270/q2rb76v7
title: BindingDB Entry 50049307: Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.

description: Small molecule binding data for protein Baculoviral IAP repeat-containing protein 2/Estrogen receptor, Uniprot P03372
DOI: 10.7270/q2w37zkk
title: BindingDB Entry 50049306: Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.

description: Small molecule binding data for protein Neuromedin-U receptor 1 and Neuromedin-U receptor 2, Uniprot O55040, Q8BZ39, Q9GZQ4, and Q9HB89
DOI: 10.15468/m747ie
title: Species composition and diagnoses of leaf- and fruit-scarring beetles (Coleoptera, Chrysomelidae) infesting bananas and plantains (Zingiberales, Musaceae) in the Indian subcontinent

description: This dataset contains the digitized treatments in Plazi based on the original journal article Prathapan, Kaniyarikkal D., Poorani, Janakiraman, Kumari, S. Amritha, Anuradha, C., Balakrishnan Padmanaban,, Thanigairaj, Ramalingam (2019): Species composition and diagnoses of leaf- and fruit-scarring beetles (Coleoptera, Chrysomelidae) infesting bananas and plantains (Zingiberales, Musaceae) in the Indian subcontinent. Deutsche Entomologische Zeitschrift 66 (2): 179-202, DOI: http://dx.doi.org/10.3897/dez.66.47447, URL: http://dx.doi.org/10.3897/dez.66.47447
DOI: 10.7270/q23n25nf
title: BindingDB Entry 50049312: Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension.

description: Small molecule binding data for protein 3',5'-cyclic phosphodiesterase, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Cytochrome P450 1A, Cytochrome P450 2B6, Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A, Phosphodiesterase 2 and 5 (PDE2 and PDE5), Phosphodiesterase 3 and 5 (PDE3 and PDE5), Phosphodiesterase 6A, Phosphodiesterase 7, Phosphodiesterase 8, Potassium voltage-gated channel subfamily H member 2, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, and cAMP-specific 3',5'-cyclic phosphodiesterase 4D, Uniprot O00408, O60658, O76074, O76083, P05177, P08684, P10632, P10635, P11712, P16499, P20813, P33261, Q01064, Q08499, Q12809, Q13946, Q14432, and Q9Y233
DOI: 10.7270/q2b56n2g
title: BindingDB Entry 50049319: Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.

description: Small molecule binding data for protein Protein-tyrosine phosphatase 1B, Uniprot P18031
DOI: 10.7270/q2fx7cr1
title: BindingDB Entry 50049318: Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS

description: Small molecule binding data for protein G protein-coupled receptor 34 and Probable G-protein coupled receptor 34, Uniprot Q9R1K6 and Q9UPC5
DOI: 10.7270/q2gt5qg3
title: BindingDB Entry 50049309: 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.

description: Small molecule binding data for protein Carbonic anhydrase and Carbonic anhydrases; II & IX, Uniprot O43570, P00915, P00918, and Q16790
DOI: 10.7270/q2kk9f3w
title: BindingDB Entry 50049317: The Fragment Network: A Chemistry Recommendation Engine Built Using a Graph Database.

description: Small molecule binding data for protein Serine/threonine-protein kinase AKT2, Uniprot P31751
DOI: 10.7270/q2qc05s9
title: BindingDB Entry 50049316: Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease.

description: Small molecule binding data for protein Glutaminyl Cyclase, Uniprot Q16769
DOI: 10.7270/q2v40xfr
title: BindingDB Entry 50049315: Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.

description: Small molecule binding data for protein N-formyl peptide receptor 2, Uniprot P25090
DOI: 10.7270/q2zw1p55
title: BindingDB Entry 50049313: Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.

description: Small molecule binding data for protein Axin-1/Glycogen synthase kinase-3 beta, Cyclin-dependent kinase 6, Cyclin-dependent kinase 9, Dual specificity protein kinase CLK1/CLK4, Dual specificity protein kinase CLK2, Dual specificity protein kinase CLK3, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Dual-specificity tyrosine-phosphorylation regulated kinase 2, Dual-specificity tyrosine-phosphorylation regulated kinase 3, Epidermal growth factor receptor, Fibroblast growth factor receptor, Mitogen-activated protein kinase 1, Serine/threonine-protein kinase ULK1, Tyrosine-protein kinase ABL1, and Tyrosine-protein kinase JAK2, Uniprot O43781, O60674, O75385, P00519, P00533, P22455, P28482, P49759, P49760, P49761, P49841, P50750, Q00534, Q13627, Q92630, Q9HAZ1, and Q9Y463
DOI: 10.7270/q22n54kz
title: BindingDB Entry 50049321: Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.

description: Small molecule binding data for protein DNA Gyrase, Uniprot P0A0K8 and P20831
DOI: 10.7270/q26d5w99
title: BindingDB Entry 50049320: Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents.

description: Small molecule binding data for protein Multidrug resistance protein 1/Multidrug resistance associated protein 1, Uniprot P08183
DOI: 10.7270/q2dz0bm6
title: BindingDB Entry 50049326: Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.

description: Small molecule binding data for protein Hexokinase type IV, Uniprot P17712
DOI: 10.7270/q2jq139g
title: BindingDB Entry 50049325: Quinazoline derivatives as selective CYP1B1 inhibitors.

description: Small molecule binding data for protein Cytochrome P450 1A, Cytochrome P450 1B1, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, and Cytochrome P450 3A, Uniprot P04798, P05177, P08684, P10635, P11712, P33261, and Q16678
DOI: 10.7270/q2pg1v0c
title: BindingDB Entry 50049324: Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy.

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 1/6, Histone deacetylase 3/Nuclear receptor corepressor 2, and Histone deacetylase 8, Uniprot A0A024QZ26, A5H660, O15379, Q13547, Q9BY41, Q9UBN7, and Q9Y618
DOI: 10.7270/q2t43wdq
title: BindingDB Entry 50049323: Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.

description: Small molecule binding data for protein 5-lipoxygenase/FLAP, Bile acid receptor, Cysteinyl leukotriene receptor, Cysteinyl leukotriene receptor 1, and Pregnane X receptor (PXR), Uniprot O75469, P20292, Q2NNR5, Q96RI1, and Q9Y271
DOI: 10.7270/q2xw4n3p
title: BindingDB Entry 50049322: Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect isletβ-cells from apoptosis.

description: Small molecule binding data for protein Aurora kinase A, Axin-1/Glycogen synthase kinase-3 beta, Cyclin-T1/Cyclin-dependent-like kinase 5, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Cyclin-dependent kinase 9, Death-associated protein kinase 1, Death-associated protein kinase 2, Death-associated protein kinase 3, Inhibitor of NF-kappa-B kinase alpha/beta, SRC, Serine/threonine-protein kinase 17A, Serine/threonine-protein kinase 17B (STK17B), Tyrosine-protein kinase BTK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase SYK, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O14920, O14965, O43293, O60674, O94768, P11802, P43405, P49841, P50750, P51451, P52333, P53355, Q00534, Q00535, Q02763, Q06187, Q08881, Q9UEE5, and Q9UIK4
DOI: 10.15468/wvisqm
title: A new specIes of the genus Stereocephalus Lynch, Į 8 8 4 from Paraguay (Coleoptera StaphylInIdae PaederInae)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Matějíček, Jan (2017): A new specIes of the genus Stereocephalus Lynch, Į 8 8 4 from Paraguay (Coleoptera StaphylInIdae PaederInae). Biodiversity Journal 9 (1): 65-68, DOI: http://doi.org/10.5281/zenodo.3576316
DOI: 10.5281/zenodo.3575106
title: IO Islamic 921. Kitâb-i-Futûḥ, Persian translation of the Arabic work فتوح ابن اعثم

description: IO Islamic 921. Kitâb-i-Futûḥ, Persian translation of the Arabic work فتوح ابن اعثم
DOI: 10.5281/zenodo.3575107
title: IO Islamic 921. Kitâb-i-Futûḥ, Persian translation of the Arabic work فتوح ابن اعثم

description: IO Islamic 921. Kitâb-i-Futûḥ, Persian translation of the Arabic work فتوح ابن اعثم
DOI: 10.3886/e115784v2
title: Effectiveness of indicators in the assessment of cognitive feigning: from type of stimuli to detection strategies An updated and extended meta-analysis

description: The present database contains 109 entries which represent studies on the assessment of neuropsychological feigning. From each study we extracted a set of outcomes used to detect cognitive feigning in groups of normal and clinical participants. Subjects considered to be feigning were labeled mal and represented the experimental group, subjects considered to be honest were labeled hon and represented the control group. We selected 3 types of contrasts between groups: honest vs malingering (hon vs mal), malingering vs malingering (mal vs mal), and honest vs honest (hon vs hon). Two studies included an extra category of participants labeled indeterminate, which generated two new contrast possibilities: honest vs indeterminate (hon vs indeterm), and indeterminate vs malingering (indeterm vs mal). Test means and SDs were extracted for each group of participants, on each scale/indicator of included measures. Extracted data also includes: sample size of experimental and control groups, type of participants (normal/diagnoses for clinical patients), type of feigning, type of research design, type of investigated cognitive process, type of indicator used by the corresponding scale, type of detection strategy, and type of stimulus.
DOI: 10.5281/zenodo.3564423
title: Transcranial detection of amyloid-beta at single plaque resolution in vivo with large-field multifocal illumination fluorescence microscopy

description: The abnormal deposition of beta-amyloid proteins in the brain is one of the major histopathological hallmarks of Alzheimer’s disease. Currently available intravital microscopy techniques can visualize plaques with high resolution, but are limited to a small field-of-view and with depth limitation. Here, we report the transcranial detection of amyloid-beta deposits at the whole brain scale with 20 mm resolution in APP/PS1 and arcAb mouse models of Alzheimer’s disease amyloidosis using a novel large-field multifocal illumination (LMI) fluorescence microscopy technique. High sensitive and specific detection of amyloid-beta deposits at single plaque level in APP/PS1 and arcAb mice was facilitated using luminescent conjugated oligothiophene HS-169. Immunohistochemical staining with HS-169, anti-Ab antibody 6E10, conformation antibodies OC (fibrillar) on brain tissue sections further showed that HS-169 resolved compact parenchymal and vessel-associated amyloid deposits. In conclusion, we demonstrate a new <em>in vivo </em>imaging platform for detection of amyloid-beta deposits at single plaque resolution in murine models of Alzheimer’s disease amyloidosis.
DOI: 10.5281/zenodo.3564424
title: Transcranial detection of amyloid-beta at single plaque resolution in vivo with large-field multifocal illumination fluorescence microscopy

description: The abnormal deposition of beta-amyloid proteins in the brain is one of the major histopathological hallmarks of Alzheimer’s disease. Currently available intravital microscopy techniques can visualize plaques with high resolution, but are limited to a small field-of-view and with depth limitation. Here, we report the transcranial detection of amyloid-beta deposits at the whole brain scale with 20 mm resolution in APP/PS1 and arcAb mouse models of Alzheimer’s disease amyloidosis using a novel large-field multifocal illumination (LMI) fluorescence microscopy technique. High sensitive and specific detection of amyloid-beta deposits at single plaque level in APP/PS1 and arcAb mice was facilitated using luminescent conjugated oligothiophene HS-169. Immunohistochemical staining with HS-169, anti-Ab antibody 6E10, conformation antibodies OC (fibrillar) on brain tissue sections further showed that HS-169 resolved compact parenchymal and vessel-associated amyloid deposits. In conclusion, we demonstrate a new <em>in vivo </em>imaging platform for detection of amyloid-beta deposits at single plaque resolution in murine models of Alzheimer’s disease amyloidosis.
DOI: 10.5281/zenodo.3575108
title: IO Islamic 248. Ta'rîkh-i-Futûḥ-i-Shâm, Persian translation of the Conquest of Syria History

description: IO Islamic 248. Ta’rîkh-i-Futûḥ-i-Shâm, Persian translation of the Conquest of Syria History
DOI: 10.5281/zenodo.3575109
title: IO Islamic 248. Ta'rîkh-i-Futûḥ-i-Shâm, Persian translation of the Conquest of Syria History

description: IO Islamic 248. Ta’rîkh-i-Futûḥ-i-Shâm, Persian translation of the Conquest of Syria History