cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.c81sr72
title: Supplemental appendix: Randomised trial of daily high-dose vitamin D3 in RRMS patients receiving sc interferon beta-1a

description: Objective In the phase II, randomized, double-blind,
 placebo-controlled Supplementation of Vigantol Oil versus Placebo Add-on
 in Patients with Relapsing-Remitting Multiple Sclerosis (RRMS) Receiving
 Rebif Treatment (SOLAR) study (NCT01285401), we assessed the efficacy and
 safety of add-on vitamin D3 in patients with RRMS.
 Methods Eligible patients with RRMS treated with SC
 interferon-β-1a (IFN-β-1a) 44 μg 3 times weekly and serum 25(OH)D levels
 &lt;150 nmol/L were included. From February 15, 2011, to May 11, 2015,
 229 patients were included and randomized 1:1 to receive SC IFN-β-1a plus
 placebo (n = 116) or SC IFN-β-1a plus oral high-dose vitamin
 D3 14,007 IU/d (n = 113). The revised primary outcome was the
 proportion of patients with no evidence of disease activity (NEDA-3) at
 week 48. Results At 48 weeks, 36.3% of patients who received
 high-dose vitamin D3 had NEDA-3, without a statistically
 significant difference in NEDA-3 status between groups (placebo 35.3%;
 odds ratio 0.93; 95% confidence interval [CI]
 0.53–1.63; p = 0.80). Compared with placebo, the
 high-dose vitamin D3 group had better MRI outcomes for combined
 unique active lesions (incidence rate ratio 0.68; 95% CI
 0.52–0.89; p = 0.0045) and change from baseline in total
 volume of T2 lesions (difference in mean ranks:
 −0.074; p = 0.035). Conclusions SOLAR did not
 establish a benefit for high-dose vitamin D3 as add-on to
 IFN-β-1a, based on the primary outcome of NEDA-3, but findings from
 exploratory outcomes suggest protective effects on development of new MRI
 lesions in patients with RRMS. Clinicaltrials.gov
 identifier NCT01285401. Classification of evidence This
 study provides Class II evidence that for patients with RRMS treated with
 SC IFN-β-1a, 48 weeks of cholecalciferol supplementation did not promote
 NEDA-3 status.
description: SOLAR datadryad
 appendix_25Feb2019
DOI: 10.5061/dryad.nk9871p
title: Data from: Pollination treatment affects fruit set and modifies marketable and storable fruit quality of commercial apples

description: Insect-mediated pollination increases yields of many crop species and some
 evidence suggests that it also influences crop quality. However, the
 mechanistic linkages between insect-mediated pollination and crop quality
 are poorly known. In this study, we explored how different pollination
 treatments affected fruit set, dry matter content (DMC), mineral content
 and storability of apples. Apple flowers supplementary pollinated with
 compatible pollen resulted in higher initial fruit set rates, higher fruit
 DMC and a tendency for lower fruit K:Ca ratio than flowers that received
 natural or no pollination. These variables are related to desirable
 quality aspects, since higher DMC is connected to higher consumer
 preference and lower K:Ca ratio is related to lower incidence of
 postharvest disorders during storage. Using structural equation modelling,
 we showed an indirect effect of pollination treatment on storability,
 however mediated by complex interactions between fruit set, fruit weight
 and K:Ca ratio. The concentrations of several elements in apples (K, Zn,
 Mg) were affected by the interaction between pollination treatment and
 apple weight, indicating that pollination affects element allocation into
 fruits. In conclusion, our study shows that pollination and the
 availability of compatible pollen needs to be considered in the management
 of orchard systems, not only to increase fruit set, but also to increase
 the quality and potentially the storability of apples.
description: R code for the
 analysis The R script with the
 final analyses for the results presented in the manuscript.
 Ap_poll_minerals_Final_analysis.R Data files on quality, storage, minerals and DMC The Zip-file Includes a R project file and four csv files with all data associated with the R script. Includes fruitset, seed set, quality variables including storage time, BRIX, firmness, acidity weight, mineral and DM content. _Samnegard_etal.zip
DOI: 10.5061/dryad.1f9d55b
title: Data from: Ready species one: exploring the use of augmented reality to enhance systematic biology with a revision of Fijian Strumigenys (Hymenoptera: Formicidae)

description: Advances in technology are rapidly changing the way people transmit, view,
 and interact with information. These advances offer new opportunities for
 researchers to share scientific discoveries with each other and the
 general public as never before. The field of revisionary biology has
 audiences confined to small groups of specialists, but the core task of
 systematic biology—documenting the endless forms of nature—is particularly
 well suited to capitalize on innovations in the realm of virtual, mixed
 and augmented reality. Interactive 3D digital models of biological
 specimens can help bridge barriers across scientific disciplines by
 circumventing technical jargon, and also promise to open exciting new
 vistas for public engagement. Here, we explore the potential of augmented
 reality for communicating the discovery of new species. As a test case, we
 revise a radiation of Strumigenys miniature trap-jaw ants in Fiji. In
 addition to traditional revisionary elements, we present an augmented
 reality application built specifically for this study. The application
 runs on mobile devices and allows users to interact with x-ray
 microtomography derived 3D specimen models and visualize 3D geographic
 distribution maps. We recognize twenty-three species in Fiji, including
 six new species: S. anorak n. sp., S. artemis n. sp., S. avatar n. sp., S.
 gunter n. sp., S. oasis n. sp., and S. parzival n. sp. This study
 demonstrates the potential of leveraging 3D data and technology for a more
 interactive systematic biology, and the need for research programs to
 develop robust and generalized tools to realize this potential.
description: Strumigenys_artemis_CASENT0186982_dicomRaw 3D-scan data of Strumigenys artemis, n. sp. holotype specimen in DICOM format.Strumigenys_anorak_CASENT0186900_dicomRaw 3D-scan data of Strumigenys anorak, n. sp. holotype specimen in DICOM format.Strumigenys_gunter_CASENT0184984_dicomRaw 3D-scan data of Strumigenys gunter, n. sp. holotype specimen in DICOM format.Strumigenys_avatar_CASENT0185902_dicomRaw 3D-scan data of Strumigenys avatar, n. sp. holotype specimen in DICOM format.Strumigenys_parzival_CASENT0186960_dicomRaw 3D-scan data of Strumigenys parzival, n. sp. holotype specimen in DICOM format.Strumigenys_oasis_CASENT0185751_dicomRaw 3D-scan data of Strumigenys oasis, n. sp. holotype specimen in DICOM format.
DOI: 10.5061/dryad.3jd86nj
title: Data from: Onset of clinical and MRI efficacy of ocrelizumab in relapsing multiple sclerosis

description: Objective: To assess the onset of ocrelizumab efficacy on brain magnetic
 resonance imaging (MRI) measures of disease activity in the Phase II study
 in relapsing-remitting multiple sclerosis (RRMS), and relapse rate in the
 pooled Phase III studies in relapsing multiple sclerosis (RMS). Methods:
 Brain MRI activity was determined in the Phase II trial at monthly
 intervals in patients with RRMS receiving placebo, ocrelizumab (600 mg),
 or intramuscular interferon (IFN) β-1a (30 μg). Annualized relapse rate
 (ARR; over various epochs) and time to first relapse were analyzed in the
 pooled population of the Phase III OPERA I and OPERA II trials in patients
 with RMS receiving ocrelizumab (600 mg) or subcutaneous IFN β-1a (44 μg).
 Results: In patients with RRMS, ocrelizumab reduced the number of new T1
 gadolinium-enhancing lesions by Week 4 vs placebo (p=0.042) and by Week 8
 vs intramuscular IFN β-1a (p&lt;0.001). Ocrelizumab also reduced the
 number of new or enlarging T2 lesions appearing between Weeks 4 and 8 vs
 both placebo and IFN β-1a (both p&lt;0.001). In patients with RMS,
 ocrelizumab significantly reduced ARR (p=0.005), and the probability of
 time to first protocol-defined relapse (p=0.014) vs subcutaneous IFN β-1a
 within the first 8 weeks. Conclusion: Epoch analysis of MRI-measured
 lesion activity in the Phase II study and relapse rate in the Phase III
 studies consistently revealed a rapid suppression of acute MRI and
 clinical disease activity following treatment initiation with ocrelizumab
 in patients with RRMS and RMS, respectively. Classification of evidence:
 This study provides Class II evidence that for patients with RRMS and RMS,
 ocrelizumab suppressed MRI activity within 4 weeks and clinical disease
 activity within 8 weeks.
description: Figure
 e-1Phase II study of
 ocrelizumab in patients with RRMSSup fig
 1_v1b.jpgFigure
 e-2Phase III OPERA I and
 OPERA II studies of ocrelizumab in patients with RMSSup fig
 2_v1b.jpgFigure
 e-3The effect of treatment
 with ocrelizumab on B-cell counts in the pooled OPERA
 populationSup fig
 3_v1b.jpgFigure
 e-4The number of new T2
 lesions in the Phase II populationSup fig
 4_v1c.jpgFigure
 e-5The number of enlarging
 T2 lesions in the Phase II populationSup fig
 5_v1c.jpg
DOI: 10.5061/dryad.55nc054
title: Data from: New physiological bench test reproducing noctural breathing pattern of patients with sleep disordered breathing

description: Previous studies have shown that Automatic Positive Airway Pressure (APAP)
 devices display different behaviors when connected to a bench using
 theoretical respiratory cycle scripts. However, these scripts are limited
 and do not simulate physiological behavior during the night. Our aim was
 to develop a physiological bench that is able to simulate patient
 breathing airflow by integrating polygraph data. We developed an algorithm
 analyzing polygraph data and transformed this information into digital
 inputs required by the bench hardware to reproduce a patient breathing
 profile on bench. The inputs are respectively the simulated respiratory
 muscular effort pressure input for an artificial lung and the sealed
 chamber pressure to regulate the Starling resistor. We did simulations on
 our bench for a total of 9 hours and 23 minutes for a breathing profile
 from the demonstration recording of a Nox T3 Sleep Monitor. The simulation
 performance results showed that in terms of relative peak-valley amplitude
 of each breathing cycle, simulated bench airflow was biased by only 1.48%
 ± 6.8% compared to estimated polygraph nasal airflow for a total of 6,479
 breathing cycles. For total respiratory cycle time, the average bias ±
 standard deviation was 0.000 ± 0.288 seconds. For patient apnea events,
 our bench simulation had a sensitivity of 84.7% and a positive predictive
 value equal to 90.3%, considering 149 apneas detected both in polygraph
 nasal airflow and simulated bench airflow. Our new physiological bench can
 personalize APAP device selection to each patient by taking into account
 individual characteristics of a sleep breathing profile.
description:  
 
  
description: The uploaded Zip file contains the original polygraph data
 issuing from one-night demonstration recording by a Nox T3 Monitor (Nox
 Medical, Reykjavik, Iceland), used by our study. They are respectively
 activity (20 Hz), RIP abdomen (25 Hz), RIP thorax (25 Hz), RIP flow (25
 Hz), nasal pressure (200 Hz), spO2 (3 Hz), audio volume (100 Hz) signals.
 It contains also all bench test result raw data, which were registered
 during bench simulation of the breathing profile contained in the
 previously described polygraph recordings. In the bench test result raw
 data files, the column Flow corresponds to the airflow simulated on bench,
 sampled at 20 Hz, with a unit of L/min. The column P1 corresponds to the
 pressure (cmH2O) measured at the upstream of Starling resistor, sampled at
 20Hz. The column P2 corresponds to the sealed chamber pressure (cmH2O) of
 Starling resistor, sampled at 20Hz. The column TTL represents the count of
 respiratory cycles.
DOI: 10.5061/dryad.p8n6q5m
title: Data from: New material of Gobicyon (Carnivora, Amphicyonidae, Haplocyoninae) from northern China and a review of Aktaucyonini evolution

description: The aberrant carnivore Gobicyon has been known for more than 80 years, but
 the evolutionary position and taxonomic diversity of this animal remain
 unclear due to the paucity of the known fossils. Here, we report a much
 richer and better preserved assemblage of Gobicyon material from Tongxin
 and Hezheng areas, northern China. Two new species, Gobicyon yei sp. nov.
 from the early Middle Miocene in Tongxin area and Gobicyon acutus sp. nov.
 from the late Middle Miocene in Hezheng area were recognised. Much better
 material of Gobicyon macrognathus and one isolated tooth of Gobicyon
 zhegalloi from Tongxin area are also described in detail. Gobicyon is
 recognised as a derived haplocyonid. A phylogenetic analysis of Gobicyon
 and related taxa was performed for the first time. The phylogenetic tree
 suggests a close relationship of Aktaucyon and Gobicyon (Aktaucyonini).
 Among the taxa traditionally included in haplocyonids, Haplocyonopsis is
 the closest to Aktaucyonini, as supported by its centrally located M1
 protocone and a uniformly distributed M1 lingual cingulum. The most
 significant evolutionary trends of Gobicyon are the reduction of the
 posterior molars (M2 and M3) and the strengthening of P4 and M1,
 suggesting a forward shift of crushing function along the tooth row.
description: matrixcharacter matrix of
 haplocyonids
DOI: 10.5061/dryad.8jj7432
title: Data from: Assessing the Recovery of an Antarctic Predator from Historical Exploitation

description: The recovery of whale populations from centuries of exploitation will
 likely have important management and ecological implications due to
 greater exposure to anthropogenic threats and increasing prey consumption.
 Here, a Bayesian population model integrates catch data, estimates of
 absolute and relative abundance, and information on genetics and biology
 to assess the recovery of western South Atlantic (WSA) humpback whales
 (Megaptera novaeangliae). Modeling scenarios are used to evaluate the
 sensitivity of model outputs resulting from the use of different data,
 different model assumptions, and uncertainty in catch allocation and in
 accounting for whales killed but not landed. A long period of exploitation
 drove WSA humpback whales to the brink of extinction. They declined from
 nearly 27,000 individuals in 1830 to only 450 whales in the mid 1950s.
 Protection led to a strong recovery and the current population is
 estimated to be at 93% of its pre-exploitation size. The recovery of WSA
 humpback whales may result in large removals of their primary prey, the
 Antarctic krill (Euphausia superba), and has the potential to modify the
 community structure in their feeding grounds. Continued monitoring is
 needed to understand how these whales will respond to modern threats and
 to climate-driven changes to their habitats.
description: Code and Data for
 "Assessing the Recovery of an Antarctic Predator from Historical
 Exploitation" A zip file containing
 the analysis results presented in Zerbini et al., as well as an empty
 directory structure and the code required to produce those results. Note
 that results were obtained using R version 3.5.2.   Code_Data_Zerbini_et_al.zip
DOI: 10.5061/dryad.pc261dp
title: Data from: The alternate hybrid method for springback prediction and die compensation

description: [No abstract entered]
description: Data_SBData of surface geometries of punch, plate, distance plate and reference. ascii data for springback, excel data dan capture of simulation
DOI: 10.5061/dryad.6c2fk58
title: Experimental investigation of insect deposition in lentic environments and implications for formation of Konservat-Lagerstätten

description: Terrestrial insects are often remarkably well preserved in lacustrine
 Konservat-Lagerstätten. However, the assumption that carcasses should sink
 fast through the water column seems to contradict evidence that this
 scenario is unlikely due to excessive buoyancy and surface tension. The
 mechanisms that promote rapid and permanent emplacement onto the sediment
 surface (RPESS) of such terrestrial animal remains are not fully
 understood. Here we use taphonomic experiments to show that floating in
 water, growth of microbial biofilms and reception of rapid sediment load
 promote RPESS of terrestrial insect remains in lentic water bodies. Our
 results show that the optimum conditions for RPESS occur when terrestrial
 insects enter a lentic water body in articulation, experience brief decay
 in association with growth of microbes, then are buried rapidly by
 airborne volcanic ash. These results provide a model for preservation of
 articulated terrestrial insects and emphasize the importance of microbial
 activity and volcanism for insect preservation in lacustrine
 Konservat-Lagerstätten.
description: S0-S4 This text
 file includes S0–S4. S0 includes information about
 the fossil specimen sectioned in this study. S1
 includes methods of measuring masses, dorsal surface areas and static
 contact angles of the experimental insects. S2 and
 S3 are details of calculating the falling velocities and external forces
 of the clasts during the sediment load. S4 is a
 list of well-studied lacustrine Lagerstätten incorporated into the
 statistical analysis.   
 S5_Experimental_records This spreadsheet includes measurements of insect characteristics and other parameters during the experiments, and the experimental records of Experiments 1, 3 and 4.   S6_S9_Experiment_2 This zip file includes experimental records of Experiment 2 in four separated spreadsheets.   S10_terrestrial_insects_lentic_PaleoDB This csv file includes the insect fossil records from "lacustrine", "crater lake" and "pond" deposits downloaded from the Paleobiology Database on 19th May 2019. Records of aquatic larvae and nymphs have been manually omitted.
DOI: 10.5061/dryad.97c1p16
title: Data from: Distribution of the specialist aphid Uroleucon nigrotuberculatum (Homoptera: Aphididae) in response to host plant semiochemical induction by the gall fly Eurosta solidaginis (Diptera: Tephritidae)

description: Many plants use terpenoids and other volatile compounds as semiochemicals.
 Reception of plant volatiles by conspecifics may trigger a defensive
 phytochemical response. These same compounds can also function as host
 recognition signals for phytophagous insects. In this experiment we find
 that when the specialist gall-forming fly Eurosta solidaginis attacks its
 tall goldenrod (Solidago altissima) host plant, the fly indirectly induces
 a phytochemical response in nearby tall goldenrod plants. This
 phytochemical response may, in turn, act as a positive signal attracting
 the goldenrod specialist aphid Uroleucon nigrotuberculatum. Laboratory
 based experiments exposing ungalled tall goldenrod plants to the volatiles
 released by E. solidaginis galls demonstrated a consistent increase in
 foliar terpenoid concentrations in ungalled plants. Analysis of tall
 goldenrod stem and gall tissue chemistry revealed induction of terpenoids
 in gall tissue, with a simultaneous decrease in green leaf volatile
 concentrations. Field experiments demonstrated a consistent spatial
 relationship in tall goldenrod foliar terpenoid concentrations with
 distance from an E. solidaginis gall. Both laboratory and field
 experiments establish consistent induction of the terpene β-farnesene, and
 that this compound is a strong positive predictor of U. nigrotuberculatum
 aphid presence on goldenrod plants along with plant biomass and several
 other foliar terpenoids. These findings suggest E. solidaginis induced
 phytochemistry, especially β-farnesene, may be acting as a kairomone,
 driving aphid distribution in the field.
description: ATRWRS_2019All data and code related to the publication are provided. Data describe Solidago altissima foliar terpenoid concentrations, Eurosta solidaginis gall tissue terpenoid concentrations, as well as field observed measurements of Uroleucon nigrotuberculatum aphid presence and host plant biomass. Please see the README.txt file for details on executing the code.
DOI: 10.5061/dryad.gr6df4k
title: Optimal control approaches for combining medicines and mosquito control in tackling dengue

description: Dengue is a debilitating and devastating viral infection spread by
 mosquito vectors, and over half the world's population currently live
 at risk of dengue (and other flavivirus) infections. Here we use an
 integrated epidemiological and vector ecology framework to predict optimal
 approaches for tackling dengue. Our aim is to investigate how vector
 control and/or vaccination strategies can be best combined and implemented
 for dengue disease control on small networks, and whether these optimal
 strategies differ under different circumstances. We show that that a
 combination of vaccination programmes and the release of genetically
 modified self-limiting mosquitoes (comparable to sterile insect
 approaches) is always considered the most beneficial strategy for reducing
 the number of infected individuals, due to both methods having differing
 impacts on the underlying disease dynamics. Additionally, depending on the
 impact of human movement on the disease dynamics, the optimal way to
 combat the spread of dengue is to focus prevention efforts on large
 population centres. Using mathematical frameworks, such as optimal
 control, are essential in developing predictive management and mitigation
 strategies for dengue disease control.
description: Accompanying
 CodeEnclosed is all the code
 used to run the optimal control studies presented in the
 manuscript.Submission.zip
DOI: 10.48366/r1581120
title: Semantic Vocabularies for Digital Product Passport and After-Sales Service

description: Comparison of RDF/OWL vocabularies addressing Digital Product Passport (DPP) requirements under EU ESPR 2024/1781. Evaluates product identification, lifecycle traceability, warranty semantics, and after-sales service workflows. Key finding: only Verisav Vocabularies provide machine-readable warranty payment rules and RMA workflows.