cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21505964.v1
title: Manually prepared lamellae for Descemet stripping endothelial keratoplasty (Pachy-DSEK): comparison of four dissection depths

description: ABSTRACT Purpose: This study aimed to compare four depths of manual dissection for the preparation of Descemet stripping endothelial keratoplasty lamellae. Methods: Eye bank corneas were randomized into four groups according to dissection depths: Pachy-100 (incision depth = central corneal thickness-safety margin of 100 µm), Pachy-50 (safety margin of 50 µm), Pachy-0 (no safety margin), and Pachy+50 (incision depth = central corneal thickness + 50 µm). All endothelial lamellae were prepared using a standardized method of manual dissection (Pachy-DSEK). The central, paracentral (3.0-mm zone), and peripheral (6.0-mm zone) lamella thicknesses and incision depths were measured by optical coherence tomography. The 3.0-mm and 6.0-mm zone central-to-peripheral thickness ratios were calculated. Results: Endothelial perforation occurred only in the Pachy+50 group (n=3, 30%). Central lamella’s thickness in Pachy-100, Pachy-50, Pachy-0, and Pachy+50 groups measured 185 ± 42 µm, 122 ± 29 µm, 114 ± 29 µm, and 58 ± 31 µm, respectively (p&lt;0.001). The overall 3.0- and 6.0-mm C/P ratios were 0.97 ± 0.06 and 0.92 ± 0.14, respectively. Preoperative donor characteristics were not correlated with most thickness outcomes. The planned incision depth correlated significantly with most lamella’s thickness parameters (p&lt;0.001). The overall thickness of the lamella negatively correlated with the planned incision depth (p&lt;0.001, r=-0.580). The best outcome was found in the Pachy-0 group, as 75% of the lamellae measured &lt;130 µm and there was no endothelial perforation. Conclusions: By using a standardized method of dissection, most manually prepared lamellae presented a planar shape. Setting the incision depth to the central corneal thickness did not result in endothelial perforation and a high percentage of ultrathin lamellae was achieved.
DOI: 10.6084/m9.figshare.21505964
title: Manually prepared lamellae for Descemet stripping endothelial keratoplasty (Pachy-DSEK): comparison of four dissection depths

description: ABSTRACT Purpose: This study aimed to compare four depths of manual dissection for the preparation of Descemet stripping endothelial keratoplasty lamellae. Methods: Eye bank corneas were randomized into four groups according to dissection depths: Pachy-100 (incision depth = central corneal thickness-safety margin of 100 µm), Pachy-50 (safety margin of 50 µm), Pachy-0 (no safety margin), and Pachy+50 (incision depth = central corneal thickness + 50 µm). All endothelial lamellae were prepared using a standardized method of manual dissection (Pachy-DSEK). The central, paracentral (3.0-mm zone), and peripheral (6.0-mm zone) lamella thicknesses and incision depths were measured by optical coherence tomography. The 3.0-mm and 6.0-mm zone central-to-peripheral thickness ratios were calculated. Results: Endothelial perforation occurred only in the Pachy+50 group (n=3, 30%). Central lamella’s thickness in Pachy-100, Pachy-50, Pachy-0, and Pachy+50 groups measured 185 ± 42 µm, 122 ± 29 µm, 114 ± 29 µm, and 58 ± 31 µm, respectively (p&lt;0.001). The overall 3.0- and 6.0-mm C/P ratios were 0.97 ± 0.06 and 0.92 ± 0.14, respectively. Preoperative donor characteristics were not correlated with most thickness outcomes. The planned incision depth correlated significantly with most lamella’s thickness parameters (p&lt;0.001). The overall thickness of the lamella negatively correlated with the planned incision depth (p&lt;0.001, r=-0.580). The best outcome was found in the Pachy-0 group, as 75% of the lamellae measured &lt;130 µm and there was no endothelial perforation. Conclusions: By using a standardized method of dissection, most manually prepared lamellae presented a planar shape. Setting the incision depth to the central corneal thickness did not result in endothelial perforation and a high percentage of ultrathin lamellae was achieved.
DOI: 10.6084/m9.figshare.21505966
title: BINARY OR NON-BINARY? GENDER MORPHOLOGY IN SPANISH: DIFFERENCES DEPENDENT ON THE TASK

description: ABSTRACT there is empirical evidence in different languages on how the computation of gender morphology during psycholinguistic processing affects the conformation of sex-generic representations. However, there is no empirical evidence on the processing of non-binary morphological variants in Spanish (-x or -e) in contrast to the generic masculine variant (-o). To analyze this phenomenon, we conducted two experiments: an acceptability judgment task and a sentence comprehension task. The results show differences depending on the task. This means that the underlying processes put into play in each one generate different effects. In acceptability judgments, which involve strategic processes mediated by beliefs and the linguistic norm, the generic masculine is more acceptable to refer to mixed groups. In the sentence comprehension task, which inquires about automatic processes and implicit representations, the non-binary forms consistently elicited a reference to mixed groups. Furthermore, the response times indicated that these morphological variants do not entail a higher processing cost than the generic masculine.
DOI: 10.6084/m9.figshare.21505966.v1
title: BINARY OR NON-BINARY? GENDER MORPHOLOGY IN SPANISH: DIFFERENCES DEPENDENT ON THE TASK

description: ABSTRACT there is empirical evidence in different languages on how the computation of gender morphology during psycholinguistic processing affects the conformation of sex-generic representations. However, there is no empirical evidence on the processing of non-binary morphological variants in Spanish (-x or -e) in contrast to the generic masculine variant (-o). To analyze this phenomenon, we conducted two experiments: an acceptability judgment task and a sentence comprehension task. The results show differences depending on the task. This means that the underlying processes put into play in each one generate different effects. In acceptability judgments, which involve strategic processes mediated by beliefs and the linguistic norm, the generic masculine is more acceptable to refer to mixed groups. In the sentence comprehension task, which inquires about automatic processes and implicit representations, the non-binary forms consistently elicited a reference to mixed groups. Furthermore, the response times indicated that these morphological variants do not entail a higher processing cost than the generic masculine.
DOI: 10.6084/m9.figshare.21505967
title: Performance of Subnational Governments in the COVID-19 Pandemic: An Analysis of the Public and Private Health Services in Brazil

description: ABSTRACT This article analyzes the differences between public and private health services regarding infrastructure and human resources at the state (subnational) and macro-regional levels in Brazil. The research collected monthly data on inpatient beds and the number of nurses, physiotherapists, and doctors from Brazilian states for 2020. Indicators were created following quarterly changes and comparing the actions of public and private healthcare entities. Variations were analyzed using temporal graphs based on means and standard deviation. The findings suggest: (1) exponential growth in health care infrastructure and human resources led by public sector investment in the second quarter, followed by a slowdown; (2) a more significant variation in the acceleration and deceleration of the public sector response in the North of Brazil and the states of Maranhão, Rio Grande do Norte, and the Federal District; (3) the public sector was the primary response mechanism to the pandemic considering the variations throughout the year. The study concludes that the government was the leading actor in response to the COVID-19 pandemic in Brazil in 2020, pointing out that responses were uneven in the states.
DOI: 10.6084/m9.figshare.21505967.v1
title: Performance of Subnational Governments in the COVID-19 Pandemic: An Analysis of the Public and Private Health Services in Brazil

description: ABSTRACT This article analyzes the differences between public and private health services regarding infrastructure and human resources at the state (subnational) and macro-regional levels in Brazil. The research collected monthly data on inpatient beds and the number of nurses, physiotherapists, and doctors from Brazilian states for 2020. Indicators were created following quarterly changes and comparing the actions of public and private healthcare entities. Variations were analyzed using temporal graphs based on means and standard deviation. The findings suggest: (1) exponential growth in health care infrastructure and human resources led by public sector investment in the second quarter, followed by a slowdown; (2) a more significant variation in the acceleration and deceleration of the public sector response in the North of Brazil and the states of Maranhão, Rio Grande do Norte, and the Federal District; (3) the public sector was the primary response mechanism to the pandemic considering the variations throughout the year. The study concludes that the government was the leading actor in response to the COVID-19 pandemic in Brazil in 2020, pointing out that responses were uneven in the states.
DOI: 10.6084/m9.figshare.21505969
title: Ophthalmological findings in patients suspected with COVID-19 at a tertiary hospital in Pernambuco, Brazil

description: ABSTRACT Purpose: This study evaluated the frequency of the most common ophthalmological, neurological, and systemic findings in symptomatic patients seen at a COVID-19 screening service at Hospital das Clínicas - Universidade Federal de Pernambuco. Methods: A total of 104 patients under clinical suspicion of SARS-CoV-2 infection underwent medical evaluation through an ophthalmological and systemic symptoms survey. All participants selected for the study underwent COVID-19 RT-PCR testing. Results: The mean age was 38.8 years, with 44.23% between 31 and 40 years old, 68.27% female, and 31.73% male. The most common symptoms in patients with a positive RT-PCR test were cough (69.23%), fever (42.3%), hyposmia (38.46%), myalgia (38.46%), and ageusia (30.77%). In the positive group, 34.61% presented with ophthalmological symptoms: burning (19.23%), eye pain (11.54%), foreign body sensation (7.7%), hyperemia (7.7%), and tearing (3.84%). Conclusions: Systemic clinical features were characteristic of upper respiratory infection, but neurological findings of hyposmia and anosmia proved to be important markers for suspicion of SARS-CoV-2 infection. Ophthalmic symptoms in patients with COVID-19 were similar to those observed in other viral conditions and may precede systemic conditions. A high rate of self-medication was observed for general symptoms compared with ophthalmological conditions.
DOI: 10.6084/m9.figshare.21505969.v1
title: Ophthalmological findings in patients suspected with COVID-19 at a tertiary hospital in Pernambuco, Brazil

description: ABSTRACT Purpose: This study evaluated the frequency of the most common ophthalmological, neurological, and systemic findings in symptomatic patients seen at a COVID-19 screening service at Hospital das Clínicas - Universidade Federal de Pernambuco. Methods: A total of 104 patients under clinical suspicion of SARS-CoV-2 infection underwent medical evaluation through an ophthalmological and systemic symptoms survey. All participants selected for the study underwent COVID-19 RT-PCR testing. Results: The mean age was 38.8 years, with 44.23% between 31 and 40 years old, 68.27% female, and 31.73% male. The most common symptoms in patients with a positive RT-PCR test were cough (69.23%), fever (42.3%), hyposmia (38.46%), myalgia (38.46%), and ageusia (30.77%). In the positive group, 34.61% presented with ophthalmological symptoms: burning (19.23%), eye pain (11.54%), foreign body sensation (7.7%), hyperemia (7.7%), and tearing (3.84%). Conclusions: Systemic clinical features were characteristic of upper respiratory infection, but neurological findings of hyposmia and anosmia proved to be important markers for suspicion of SARS-CoV-2 infection. Ophthalmic symptoms in patients with COVID-19 were similar to those observed in other viral conditions and may precede systemic conditions. A high rate of self-medication was observed for general symptoms compared with ophthalmological conditions.
DOI: 10.6084/m9.figshare.21505973
title: Ocular manifestation of vertical transmission of dengue: case report

description: ABSTRACT A 7-week-old male delivered by cesarean section presented with a positive serology for dengue along with preretinal and retinal hemorrhages, vitreous opacities and cotton wool spots. The patient and his mother had positive serologies for Non Structural Protein 1 (NS1) by ELISA. Retinal and vitreous findings improved over a sixteen-week period. Spectral domain optical coherence tomography (OCT) showed preserved macular architecture. In this case report, we suggest that retinal and vitreous changes may be the ocular presenting features of vertically transmitted dengue in newborns, and that those findings may resolve with no major structural sequelae.
DOI: 10.6084/m9.figshare.21505973.v1
title: Ocular manifestation of vertical transmission of dengue: case report

description: ABSTRACT A 7-week-old male delivered by cesarean section presented with a positive serology for dengue along with preretinal and retinal hemorrhages, vitreous opacities and cotton wool spots. The patient and his mother had positive serologies for Non Structural Protein 1 (NS1) by ELISA. Retinal and vitreous findings improved over a sixteen-week period. Spectral domain optical coherence tomography (OCT) showed preserved macular architecture. In this case report, we suggest that retinal and vitreous changes may be the ocular presenting features of vertically transmitted dengue in newborns, and that those findings may resolve with no major structural sequelae.
DOI: 10.6084/m9.figshare.20485563
title: Estimation of net ecosystem carbon exchange at climate sites by combing remote sensing data and FLUXNET2015 data with machine learning algorithms

description: The Eddy Covariance (EC) flux stations have great limitations in the evaluation of the global Net ecosystem carbon exchange (NEE) and in the uncertainty reduction due to their sparse and uneven distribution and spatial representation. If the EC stations are linked with widely distributed meteorological stations using machine learning (ML) and remote sensing, it will play a big role in effectively improving the accuracy of the global NEE assessment and reducing the uncertainty. In this study, we first optimized the hyperparameters and input variables of the ML model based on the adaptive genetic algorithm. Then, we developed 566 random forest (RF)-based NEE estimation models by the strategy of spatial leave-out-one cross- validation (SLOOCV). We innovatively established the Euclidean distance-based accuracy projection algorithm of the R square (R2), which could test the accuracy for each model to estimate the NEE of the specific flux at the weather station. Only the model with the highest R2 was selected from the models with a prediction accuracy of R2&gt;0.5 for the specific meteorological stations to estimate its NEE. 4,674 out of 10,289 weather stations around the world might match at least one of the 566 NEE estimation models with a projected accuracy of R2 &gt; 0.5. The NEE estimation models we screened for the meteorological stations showed a reliable performance and a higher accuracy than former studies. The NEE values of the most (96.9%) screened meteorological stations around the world are negative (carbon sink) and most (65.3%) of those showed an increasing trend in the mean annual NEE (carbon sink). The FLUXCOM NEE estimation denoted larger values than our estimations at the corresponding meteorological stations. The NEE dataset produced at the meteorological stations could be used as a supplement to the EC observations and quasi-observation data to assess the NEE products of the global grid. The results of this work will provide theoretical and technical support for the climate change policy formulation and the terrestrial carbon sink assessments.
DOI: 10.6084/m9.figshare.21505975
title: Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women

description: Abstract Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains eNOS in the inactivated state leading to reduced nitric oxide (NO) production. Ischemic preconditioning disrupts the caveolin-eNOS complex leading to activation of the eNOS and thus results in cardioprotection. During ischemic preconditioning, NO produces cardioprotection by the opening of the KATP channel, and the caveolin forms a suitable signalling platform facilitating the interaction of NO with the KATP channel. Estrogen deficiency has been reported to upregulate caveolin-1 expression. The article aims to review the various mechanisms that placed the women at the risk of coronary artery diseases after postmenopausal estrogen deficiency and their role in the cardioprotective effect of ischemic preconditioning.
DOI: 10.6084/m9.figshare.21505975.v1
title: Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women

description: Abstract Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains eNOS in the inactivated state leading to reduced nitric oxide (NO) production. Ischemic preconditioning disrupts the caveolin-eNOS complex leading to activation of the eNOS and thus results in cardioprotection. During ischemic preconditioning, NO produces cardioprotection by the opening of the KATP channel, and the caveolin forms a suitable signalling platform facilitating the interaction of NO with the KATP channel. Estrogen deficiency has been reported to upregulate caveolin-1 expression. The article aims to review the various mechanisms that placed the women at the risk of coronary artery diseases after postmenopausal estrogen deficiency and their role in the cardioprotective effect of ischemic preconditioning.
DOI: 10.6084/m9.figshare.21505976
title: Trends in Graves’ orbitopathy research in the past two decades: a bibliometric analysis

description: ABSTRACT Purpose: This study was conducted to identify trends in Graves’ orbitopathy research in the past two decades and to elaborate on hot topics in the field. Methods: The Web of Science database was used to extract articles on Graves’ orbitopathy or its synonyms. Full data and references were exported to VOSviewer software to be analyzed. Visualization maps and charts were constructed accordingly. Results: We retrieved 1067 articles on Graves’ orbitopathy from the Web of Science database. The United States ranked first in terms of the article count (25), followed by Italy (141) and the People’s Republic of China (120). Wiersinga’s and the University of Amsterdam’s articles received the highest citation count (1509 and 3052, respectively). The University of Pisa and Thyroid published the highest number of articles (65 and 93, respectively). Co-authorship analysis showed four clusters of country collaborations: red cluster, European countries; green cluster, the United States, Brazil, Canada, South Korea, and Taiwan; a yellow cluster, People’s Republic of China; and blue cluster, Japan, Australia, and Poland. Keyword analysis revealed five clusters of topics: pathogenesis, management, association, quality of life, and surgery. Analysis of co-cited references also revealed five clusters: pathogenesis, management, risk factors, clinical assessment, and surgical management. Conclusion: Research on Graves’ orbitopathy has grown during the past two decades. Hot research topics are pathogenesis, management, risk factors, quality of life, and complications. Research trends have changed in the past two decades. Increasing interest in exploring Graves’ orbitopathy mechanisms and associations is evident. European countries are cooperating in this field of research. The United States has established more extensive international cooperation than other countries. We believe that more international collaboration involving developing countries is required.
DOI: 10.6084/m9.figshare.21505976.v1
title: Trends in Graves’ orbitopathy research in the past two decades: a bibliometric analysis

description: ABSTRACT Purpose: This study was conducted to identify trends in Graves’ orbitopathy research in the past two decades and to elaborate on hot topics in the field. Methods: The Web of Science database was used to extract articles on Graves’ orbitopathy or its synonyms. Full data and references were exported to VOSviewer software to be analyzed. Visualization maps and charts were constructed accordingly. Results: We retrieved 1067 articles on Graves’ orbitopathy from the Web of Science database. The United States ranked first in terms of the article count (25), followed by Italy (141) and the People’s Republic of China (120). Wiersinga’s and the University of Amsterdam’s articles received the highest citation count (1509 and 3052, respectively). The University of Pisa and Thyroid published the highest number of articles (65 and 93, respectively). Co-authorship analysis showed four clusters of country collaborations: red cluster, European countries; green cluster, the United States, Brazil, Canada, South Korea, and Taiwan; a yellow cluster, People’s Republic of China; and blue cluster, Japan, Australia, and Poland. Keyword analysis revealed five clusters of topics: pathogenesis, management, association, quality of life, and surgery. Analysis of co-cited references also revealed five clusters: pathogenesis, management, risk factors, clinical assessment, and surgical management. Conclusion: Research on Graves’ orbitopathy has grown during the past two decades. Hot research topics are pathogenesis, management, risk factors, quality of life, and complications. Research trends have changed in the past two decades. Increasing interest in exploring Graves’ orbitopathy mechanisms and associations is evident. European countries are cooperating in this field of research. The United States has established more extensive international cooperation than other countries. We believe that more international collaboration involving developing countries is required.