DOI: 10.7270/q2db82rh
title: BindingDB Entry 50038381: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

description: Small molecule binding data for protein 5-lipoxygenase/FLAP, AKT/p21CIP1, Adenosine kinase, Aryl hydrocarbon receptor, Aurora kinase B/Inner centromere protein, C-RAF, CDK6/G1/S-specific cyclin D3, CFTR, CaM kinase IV, CaM-kinase kinase alpha, CaM-kinase kinase beta, Calcium dependent protein kinase, Casein Kinase II, Casein kinase I delta/epsilon, Casein kinase I isoform alpha (CK1 Alpha), Casein kinase I isoform delta, Casein kinase II subunit alpha, Cyclin-Dependent Kinase 1 (CDK1), Cyclin-Dependent Kinase 7 (CDK7), Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cyclin-dependent kinase 5 regulatory subunit 1, Cyclin-dependent kinase 9, Cyclooxygenase-1 (COX-1), DNA-dependent protein kinase, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity protein kinase CLK1, Dual specificity protein kinase CLK2, Dual specificity protein kinase CLK3, Dual specificity protein kinase CLK4, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Ephrin type-B receptor 3 (EPHB3), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Inhibitor of NF-kappa-B kinase (IKK), Insulin-like growth factor I receptor, JAK2/TYK2, JAK3/JAK1, MAP kinase ERK2, MAP kinase p38, MAP kinase-activated protein kinase 2, Macrophage colony stimulating factor receptor, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 13 (MAPK13), Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 8, Nitric oxide synthase, inducible, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit gamma, PKC alpha and beta-2, Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α), Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide, Phospholipase A2, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Protein kinase C (PKC), Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C, epsilon, Protein kinase C, gamma, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), Receptor tyrosine-protein kinase erbB-4 (HER4), Rho-associated protein kinase, SM myosin light chain kinase (smMLCK), SRC, Serine-protein kinase ATM, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase CHK2, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase EEF2K, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK3, TGF-beta receptor type I, Topoisomerase II alpha (HuTopoIIα), Transcription factor AP-1, Tyrosine- and threonine-specific cdc2-inhibitory kinase, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BTK, Tyrosine-protein kinase CSK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), c-Jun N-terminal kinase, JNK, and p38 delta/gamma, Uniprot L7RSL3, O00418, O00750, O14757, O14920, O14965, O15111, O15264, O35491, O35492, O35493, O60674, O75116, O96017, P00519, P00533, P04049, P04054, P04626, P05129, P05412, P05771, P06239, P06241, P06493, P07333, P07947, P07948, P08069, P08581, P08631, P09619, P09917, P10721, P11309, P11362, P11388, P11802, P12931, P13569, P14635, P16234, P17252, P17948, P22518, P23219, P24941, P27361, P27986, P28482, P29597, P30281, P31749, P35228, P35869, P35916, P35918, P35968, P36507, P36888, P36897, P40231, P41240, P41279, P42336, P42338, P43403, P43405, P45983, P45984, P45985, P46734, P48729, P48730, P48736, P49137, P49674, P49840, P49841, P50613, P50750, P51813, P51946, P52332, P52333, P53778, P53779, P54753, P55263, P68400, P78527, Q00534, Q02156, Q02750, Q02763, Q05513, Q05655, Q06187, Q08881, Q13315, Q13464, Q13535, Q13627, Q15078, Q15118, Q15303, Q15746, Q15759, Q16539, Q16566, Q6FI23, Q8N5S9, Q96GD4, Q96RR4, Q99640, Q9H4B4, and Q9P1W9