cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.2375545
title: Can new passenger cars reduce pedestrian lower extremity injury? A review of geometrical changes of front-end design before and after regulatory efforts

description: <b>Objective</b>: Pedestrian lower extremity represents the most frequently injured body region in car-to-pedestrian accidents. The European Directive concerning pedestrian safety was established in 2003 for evaluating pedestrian protection performance of car models. However, design changes have not been quantified since then. The goal of this study was to investigate front-end profiles of representative passenger car models and the potential influence on pedestrian lower extremity injury risk. <b>Methods</b>: The front-end styling of sedans and sport utility vehicles (SUV) released from 2008 to 2011 was characterized by the geometrical parameters related to pedestrian safety and compared to representative car models before 2003. The influence of geometrical design change on the resultant risk of injury to pedestrian lower extremity—that is, knee ligament rupture and long bone fracture—was estimated by a previously developed assessment tool assuming identical structural stiffness. Based on response surface generated from simulation results of a human body model (HBM), the tool provided kinematic and kinetic responses of pedestrian lower extremity resulted from a given car's front-end design. <b>Results</b>: Newer passenger cars exhibited a “flatter” front-end design. The median value of the sedan models provided 87.5 mm less bottom depth, and the SUV models exhibited 94.7 mm less bottom depth. In the lateral impact configuration similar to that in the regulatory test methods, these geometrical changes tend to reduce the injury risk of human knee ligament rupture by 36.6 and 39.6% based on computational approximation. The geometrical changes did not significantly influence the long bone fracture risk. <b>Conclusions</b>: The present study reviewed the geometrical changes in car front-ends along with regulatory concerns regarding pedestrian safety. A preliminary quantitative benefit of the lower extremity injury reduction was estimated based on these geometrical features. Further investigation is recommended on the structural changes and inclusion of more accident scenarios.
DOI: 10.6084/m9.figshare.2375545.v1
title: Can new passenger cars reduce pedestrian lower extremity injury? A review of geometrical changes of front-end design before and after regulatory efforts

description: <b>Objective</b>: Pedestrian lower extremity represents the most frequently injured body region in car-to-pedestrian accidents. The European Directive concerning pedestrian safety was established in 2003 for evaluating pedestrian protection performance of car models. However, design changes have not been quantified since then. The goal of this study was to investigate front-end profiles of representative passenger car models and the potential influence on pedestrian lower extremity injury risk. <b>Methods</b>: The front-end styling of sedans and sport utility vehicles (SUV) released from 2008 to 2011 was characterized by the geometrical parameters related to pedestrian safety and compared to representative car models before 2003. The influence of geometrical design change on the resultant risk of injury to pedestrian lower extremity—that is, knee ligament rupture and long bone fracture—was estimated by a previously developed assessment tool assuming identical structural stiffness. Based on response surface generated from simulation results of a human body model (HBM), the tool provided kinematic and kinetic responses of pedestrian lower extremity resulted from a given car's front-end design. <b>Results</b>: Newer passenger cars exhibited a “flatter” front-end design. The median value of the sedan models provided 87.5 mm less bottom depth, and the SUV models exhibited 94.7 mm less bottom depth. In the lateral impact configuration similar to that in the regulatory test methods, these geometrical changes tend to reduce the injury risk of human knee ligament rupture by 36.6 and 39.6% based on computational approximation. The geometrical changes did not significantly influence the long bone fracture risk. <b>Conclusions</b>: The present study reviewed the geometrical changes in car front-ends along with regulatory concerns regarding pedestrian safety. A preliminary quantitative benefit of the lower extremity injury reduction was estimated based on these geometrical features. Further investigation is recommended on the structural changes and inclusion of more accident scenarios.
DOI: 10.6084/m9.figshare.2375812
title: Methylation profiling identified novel differentially methylated markers including <i>OPCML</i> and <i>FLRT2</i> in prostate cancer

description: To develop new methods to distinguish indolent from aggressive prostate cancers (PCa), we utilized comprehensive high-throughput array-based relative methylation (CHARM) assay to identify differentially methylated regions (DMRs) throughout the genome, including both CpG island (CGI) and non-CGI regions in PCa patients based on Gleason grade. Initially, 26 samples, including 8 each of low [Gleason score (GS) 6] and high (GS ≥7) grade PCa samples and 10 matched normal prostate tissues, were analyzed as a discovery cohort. We identified 3,567 DMRs between normal and cancer tissues, and 913 DMRs distinguishing low from high-grade cancers. Most of these DMRs were located at CGI shores. The top 5 candidate DMRs from the low vs. high Gleason comparison, including <i>OPCML, ELAVL2, EXT1, IRX5</i>, and <i>FLRT2</i>, were validated by pyrosequencing using the discovery cohort. <i>OPCML</i> and <i>FLRT2</i> were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci. When GS 3+4 cases and GS 4+3 cases were compared, <i>OPCML</i>-DMR methylation showed a trend of lower methylation in the recurrence group (n=30) than in the no-recurrence (n=52) group. We conclude that whole-genome methylation profiling with CHARM revealed distinct patterns of differential DNA methylation between normal prostate and PCa tissues, as well as between different risk groups of PCa as defined by Gleason scores. A panel of selected DMRs may serve as novel surrogate biomarkers for Gleason score in PCa.
DOI: 10.6084/m9.figshare.2375812.v1
title: Methylation profiling identified novel differentially methylated markers including <i>OPCML</i> and <i>FLRT2</i> in prostate cancer

description: To develop new methods to distinguish indolent from aggressive prostate cancers (PCa), we utilized comprehensive high-throughput array-based relative methylation (CHARM) assay to identify differentially methylated regions (DMRs) throughout the genome, including both CpG island (CGI) and non-CGI regions in PCa patients based on Gleason grade. Initially, 26 samples, including 8 each of low [Gleason score (GS) 6] and high (GS ≥7) grade PCa samples and 10 matched normal prostate tissues, were analyzed as a discovery cohort. We identified 3,567 DMRs between normal and cancer tissues, and 913 DMRs distinguishing low from high-grade cancers. Most of these DMRs were located at CGI shores. The top 5 candidate DMRs from the low vs. high Gleason comparison, including <i>OPCML, ELAVL2, EXT1, IRX5</i>, and <i>FLRT2</i>, were validated by pyrosequencing using the discovery cohort. <i>OPCML</i> and <i>FLRT2</i> were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci. When GS 3+4 cases and GS 4+3 cases were compared, <i>OPCML</i>-DMR methylation showed a trend of lower methylation in the recurrence group (n=30) than in the no-recurrence (n=52) group. We conclude that whole-genome methylation profiling with CHARM revealed distinct patterns of differential DNA methylation between normal prostate and PCa tissues, as well as between different risk groups of PCa as defined by Gleason scores. A panel of selected DMRs may serve as novel surrogate biomarkers for Gleason score in PCa.
DOI: 10.6084/m9.figshare.2382304
title: A Statistical Framework for Improved Automatic Flaw Detection in Nondestructive Evaluation Images

description: Nondestructive evaluation (NDE) techniques are widely used to detect flaws in critical components of systems like aircraft engines, nuclear power plants, and oil pipelines to prevent catastrophic events. Many modern NDE systems generate image data. In some applications, an experienced inspector performs the tedious task of visually examining every image to provide accurate conclusions about the existence of flaws. This approach is labor-intensive and can cause misses due to operator ennui. Automated evaluation methods seek to eliminate human-factors variability and improve throughput. Simple methods based on peak amplitude in an image are sometimes employed and a trained-operator-controlled refinement that uses a dynamic threshold based on signal-to-noise ratio (SNR) has also been implemented. We develop an automated and optimized detection procedure that mimics these operations. The primary goal of our methodology is to reduce the number of images requiring expert visual evaluation by filtering out images that are overwhelmingly definitive on the existence or absence of a flaw. We use an appropriate model for the observed values of the SNR-detection criterion to estimate the probability of detection. Our methodology outperforms current methods in terms of its ability to detect flaws. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.2382304.v1
title: A Statistical Framework for Improved Automatic Flaw Detection in Nondestructive Evaluation Images

description: Nondestructive evaluation (NDE) techniques are widely used to detect flaws in critical components of systems like aircraft engines, nuclear power plants, and oil pipelines to prevent catastrophic events. Many modern NDE systems generate image data. In some applications, an experienced inspector performs the tedious task of visually examining every image to provide accurate conclusions about the existence of flaws. This approach is labor-intensive and can cause misses due to operator ennui. Automated evaluation methods seek to eliminate human-factors variability and improve throughput. Simple methods based on peak amplitude in an image are sometimes employed and a trained-operator-controlled refinement that uses a dynamic threshold based on signal-to-noise ratio (SNR) has also been implemented. We develop an automated and optimized detection procedure that mimics these operations. The primary goal of our methodology is to reduce the number of images requiring expert visual evaluation by filtering out images that are overwhelmingly definitive on the existence or absence of a flaw. We use an appropriate model for the observed values of the SNR-detection criterion to estimate the probability of detection. Our methodology outperforms current methods in terms of its ability to detect flaws. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.2410807
title: Episodic Mesozoic constructional events of central South China: constraints from lines of evidence of superimposed folds, fault kinematic analysis, and magma geochronology

description: The South China block (SCB), located in the convergence zones of the western Pacific subduction tectonic domain and Tethyan tectonic domain, has experienced complex tectonic processes, including the continent–continent collision caused by the closure of the Palaeo-Tethys Ocean, and the subduction of the Palaeo-Pacific plate. However, due to complex intracontinental deformation and abundant magmatism, there are serious divergences in the corresponding records of the tectonic transformation from Palaeo-Tethys to Palaeo-Pacific. We have analysed the map-scale superimposed fold system developed in central SCB and also inverted the palaeo-stress field based on the fault–slip vectors. On this basis, the deformation styles and superposition mechanism of two-stage folds were recovered to establish the tectonic stress field in early Mesozoic and tectono-magmatic events by combining the chronology of the accompanying syntectonic magma. The early E–W/WNW-trending folds and Triassic magmatic system were identified; these were controlled by the NE–SW-trending compressive stress field, to coordinate with the collisions between the SCB and the Indochina block in the southwest, and the North China block in the north. The late NE/NNE-trending folds superimposed on the early folds in an orthogonal way to form a large-scale dome-basin superimposed fold system, which were controlled by the WNW–ESE-trending compressive stress field. According to the strata relations involved in deformation and the chronology data of magmatic rocks, it could be determined that NE/ENE-trending folds would be formed during the Mid- to Late Jurassic, corresponding to the westward subduction events of the Palaeo-Pacific plate. The establishment of the large-scale superimposed fold styles and the identification of fold deformation in the Triassic and Jurassic are important for understanding the early Mesozoic tectonics of South China, and even for all East Asia continent. In particular, it can provide important temporal and spatial constraints to explain the complex deformation process and geodynamic settings of South China in the early Mesozoic.
DOI: 10.6084/m9.figshare.2416231
title: Robust scheduling for multi-objective flexible job-shop problems with flexible workdays

description: This study determines a robust schedule for a flexible job-shop scheduling problem with flexible workdays. The performance criteria considered in this study are tardiness, overtime and robustness. Furthermore, the problem is addressed in a Pareto manner, and a set of Pareto-optimal solutions is determined for this purpose. In consideration of all the aforementioned features, a goal-guided neighbourhood function is proposed based on efficient problem-dependent move-filtering methods. Two metaheuristic algorithms, named goal-guided multi-objective tabu search and goal-guided multi-objective hybrid search, are proposed in this work based on this neighbourhood function. The effectiveness of these approaches is demonstrated via empirical studies.
DOI: 10.6084/m9.figshare.2410807.v1
title: Episodic Mesozoic constructional events of central South China: constraints from lines of evidence of superimposed folds, fault kinematic analysis, and magma geochronology

description: The South China block (SCB), located in the convergence zones of the western Pacific subduction tectonic domain and Tethyan tectonic domain, has experienced complex tectonic processes, including the continent–continent collision caused by the closure of the Palaeo-Tethys Ocean, and the subduction of the Palaeo-Pacific plate. However, due to complex intracontinental deformation and abundant magmatism, there are serious divergences in the corresponding records of the tectonic transformation from Palaeo-Tethys to Palaeo-Pacific. We have analysed the map-scale superimposed fold system developed in central SCB and also inverted the palaeo-stress field based on the fault–slip vectors. On this basis, the deformation styles and superposition mechanism of two-stage folds were recovered to establish the tectonic stress field in early Mesozoic and tectono-magmatic events by combining the chronology of the accompanying syntectonic magma. The early E–W/WNW-trending folds and Triassic magmatic system were identified; these were controlled by the NE–SW-trending compressive stress field, to coordinate with the collisions between the SCB and the Indochina block in the southwest, and the North China block in the north. The late NE/NNE-trending folds superimposed on the early folds in an orthogonal way to form a large-scale dome-basin superimposed fold system, which were controlled by the WNW–ESE-trending compressive stress field. According to the strata relations involved in deformation and the chronology data of magmatic rocks, it could be determined that NE/ENE-trending folds would be formed during the Mid- to Late Jurassic, corresponding to the westward subduction events of the Palaeo-Pacific plate. The establishment of the large-scale superimposed fold styles and the identification of fold deformation in the Triassic and Jurassic are important for understanding the early Mesozoic tectonics of South China, and even for all East Asia continent. In particular, it can provide important temporal and spatial constraints to explain the complex deformation process and geodynamic settings of South China in the early Mesozoic.
DOI: 10.6084/m9.figshare.2416231.v1
title: Robust scheduling for multi-objective flexible job-shop problems with flexible workdays

description: This study determines a robust schedule for a flexible job-shop scheduling problem with flexible workdays. The performance criteria considered in this study are tardiness, overtime and robustness. Furthermore, the problem is addressed in a Pareto manner, and a set of Pareto-optimal solutions is determined for this purpose. In consideration of all the aforementioned features, a goal-guided neighbourhood function is proposed based on efficient problem-dependent move-filtering methods. Two metaheuristic algorithms, named goal-guided multi-objective tabu search and goal-guided multi-objective hybrid search, are proposed in this work based on this neighbourhood function. The effectiveness of these approaches is demonstrated via empirical studies.
DOI: 10.6084/m9.figshare.2556007
title: Ore-forming granites from Jurassic porphyry Mo deposits, east–central Jilin Province, China: geochemistry, geochronology, and petrogenesis

description: The east–central part of Jilin Province, NE China, hosts an important polymetallic metallogenic district that contains more than 10 recently discovered large-, medium-, and small-scale Mo deposits. The Mo deposits in this area include porphyry-, skarn-, and quartz vein-type mineralization, of which the porphyry-type deposits dominate. Few studies of these mineralization-related granitoids have been undertaken. Here, we present the results of a systematic regional survey of the geochemistry and geochronology of Mo mineralization-related granites in this area. Zircon U–Pb dating of the Fuanpu, Jidetun, Shuangshan, and Jiapigou granites, all of which are associated with Mo mineralization, yielded weighted mean <sup>206</sup>Pb<i>/</i><sup>238</sup>U ages of 167.05 ± 0.81, 170.91 ± 0.83, 183.8 ± 1.1, and 182.3 ± 2.2 Ma, respectively, indicating that these plutons were emplaced during the Early–Middle Jurassic. They have SiO<sub>2</sub> = 62.59–73.5 wt.%, Al<sub>2</sub>O<sub>3</sub> = 13.74–16.19 wt.%, and K<sub>2</sub>O/Na<sub>2</sub>O = 0.8–2.18. Chemically, they are metaluminous to peraluminous and belong to the high-K calc-alkaline to shoshonitic series. Moreover, they are enriched in large ion lithophile elements and light rare earth elements, and are depleted in high field strength elements, which are characteristics of I type granite. Whole rock Sr–Nd–Pb isotopic compositions of these granitoids are similar (initial <sup>87</sup>Sr/<sup>86</sup>Sr = 0.70404 to 0.70554; <i>ε</i>Nd(<i>t</i>) = –0.9 to 2.4; (<sup>206</sup>Pb/<sup>204</sup>Pb)<i><sub>t</sub></i> = 15.549–15.567, (<sup>207</sup>Pb/<sup>204</sup>Pb)<i><sub>t</sub></i> = 18.035–18.530, <sup>(208</sup>Pb/<sup>204</sup>Pb)<i><sub>t</sub></i> = 37.966–38.229) and altogether suggest that the magmas from which the Mo deposits were generated originated from the mantle or juvenile crust. Combining our results with regional Jurassic tectonic setting, we conclude that the mineralization of these granitoids reflected Pacific plate subduction which induced magma underplating and promoted the remelting of the juvenile crust, resulting in voluminous granitic magma.
DOI: 10.6084/m9.figshare.2556007.v1
title: Ore-forming granites from Jurassic porphyry Mo deposits, east–central Jilin Province, China: geochemistry, geochronology, and petrogenesis

description: The east–central part of Jilin Province, NE China, hosts an important polymetallic metallogenic district that contains more than 10 recently discovered large-, medium-, and small-scale Mo deposits. The Mo deposits in this area include porphyry-, skarn-, and quartz vein-type mineralization, of which the porphyry-type deposits dominate. Few studies of these mineralization-related granitoids have been undertaken. Here, we present the results of a systematic regional survey of the geochemistry and geochronology of Mo mineralization-related granites in this area. Zircon U–Pb dating of the Fuanpu, Jidetun, Shuangshan, and Jiapigou granites, all of which are associated with Mo mineralization, yielded weighted mean <sup>206</sup>Pb<i>/</i><sup>238</sup>U ages of 167.05 ± 0.81, 170.91 ± 0.83, 183.8 ± 1.1, and 182.3 ± 2.2 Ma, respectively, indicating that these plutons were emplaced during the Early–Middle Jurassic. They have SiO<sub>2</sub> = 62.59–73.5 wt.%, Al<sub>2</sub>O<sub>3</sub> = 13.74–16.19 wt.%, and K<sub>2</sub>O/Na<sub>2</sub>O = 0.8–2.18. Chemically, they are metaluminous to peraluminous and belong to the high-K calc-alkaline to shoshonitic series. Moreover, they are enriched in large ion lithophile elements and light rare earth elements, and are depleted in high field strength elements, which are characteristics of I type granite. Whole rock Sr–Nd–Pb isotopic compositions of these granitoids are similar (initial <sup>87</sup>Sr/<sup>86</sup>Sr = 0.70404 to 0.70554; <i>ε</i>Nd(<i>t</i>) = –0.9 to 2.4; (<sup>206</sup>Pb/<sup>204</sup>Pb)<i><sub>t</sub></i> = 15.549–15.567, (<sup>207</sup>Pb/<sup>204</sup>Pb)<i><sub>t</sub></i> = 18.035–18.530, <sup>(208</sup>Pb/<sup>204</sup>Pb)<i><sub>t</sub></i> = 37.966–38.229) and altogether suggest that the magmas from which the Mo deposits were generated originated from the mantle or juvenile crust. Combining our results with regional Jurassic tectonic setting, we conclude that the mineralization of these granitoids reflected Pacific plate subduction which induced magma underplating and promoted the remelting of the juvenile crust, resulting in voluminous granitic magma.