cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48597/k4fx-4nsj
title: Particle_number_size_distribution at Aspvreten

description: Measurement of Particle_number_size_distribution at Aspvreten
DOI: 10.48597/kqm6-jtgv
title: Inorganics in air and particle phase at Hanoi

description: Measurement of Inorganics in air and particle phase at Hanoi
DOI: 10.48597/ksxr-6gqz
title: Particle_number_size_distribution at Hyytiälä

description: Measurement of Particle_number_size_distribution at Hyytiälä
DOI: 10.48597/m74z-jssj
title: Magnesium at Hoa Binh

description: Measurement of Magnesium at Hoa Binh
DOI: 10.48597/mhjs-rx39
title: Aerosol_absorption_coefficient at Melpitz

description: Measurement of Aerosol_absorption_coefficient at Melpitz
DOI: 10.48597/mkuu-nwzp
title: Sum_nitric_acid_and_nitrate at Bredkälen

description: Measurement of Sum_nitric_acid_and_nitrate at Bredkälen
DOI: 10.48597/n2bv-ws5n
title: Hydrochloric_acid at Serpong

description: Measurement of Hydrochloric_acid at Serpong
DOI: 10.48597/n43c-8jq9
title: Aerosol_absorption_coefficient at Aspvreten

description: Measurement of Aerosol_absorption_coefficient at Aspvreten
DOI: 10.48597/nxrp-ay78
title: Inorganics in air and particle phase at Chiang Mai - Mae Hia

description: Measurement of Inorganics in air and particle phase at Chiang Mai - Mae Hia
DOI: 10.48597/pg6z-f48v
title: Inorganics in air and particle phase at Cheju

description: Measurement of Inorganics in air and particle phase at Cheju
DOI: 10.48597/pwmu-bhpp
title: PM mass at Agia Marina Xyliatou / Cyprus Atmospheric Observatory

description: Measurement of PM mass at Agia Marina Xyliatou / Cyprus Atmospheric Observatory
DOI: 10.48597/q2q5-sxhm
title: Inorganics in air and particle phase at Vachiralongkorn Dam - Khanchanaburi

description: Measurement of Inorganics in air and particle phase at Vachiralongkorn Dam - Khanchanaburi
DOI: 10.48597/qxr8-spcq
title: Aerosol_light_scattering_coefficient at Finokalia

description: Measurement of Aerosol_light_scattering_coefficient at Finokalia
DOI: 10.48597/qygp-auau
title: Inorganics in air and particle phase at Petaling Jaya

description: Measurement of Inorganics in air and particle phase at Petaling Jaya
DOI: 10.48597/r6mw-x3ht
title: Calcium and heavy metals at Vredepeel

description: Measurement of Calcium and heavy metals at Vredepeel
DOI: 10.48597/r6yc-dvd9
title: Inorganics in air and particle phase at Los Banos

description: Measurement of Inorganics in air and particle phase at Los Banos
DOI: 10.48597/rf5u-ek4m
title: Inorganics in air and particle phase at Sado-seki

description: Measurement of Inorganics in air and particle phase at Sado-seki
DOI: 10.48597/s74s-39ck
title: Inorganics in air and particle phase at Imsil

description: Measurement of Inorganics in air and particle phase at Imsil
DOI: 10.48597/s9eq-wjy8
title: Inorganics in air and particle phase at Chiang Mai - Mae Hia

description: Measurement of Inorganics in air and particle phase at Chiang Mai - Mae Hia
DOI: 10.48597/sbqj-qkrw
title: Inorganics in air and particle phase at Vachiralongkorn Dam - Khanchanaburi

description: Measurement of Inorganics in air and particle phase at Vachiralongkorn Dam - Khanchanaburi
DOI: 10.6084/m9.figshare.14115239
title: Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

description: Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against glioma; however, the molecular target and mechanism of action of CBD in glioma are poorly understood. Here we investigated the molecular mechanisms underlying the antitumor effect of CBD in preclinical models of human glioma. Our results showed that CBD induced autophagic rather than apoptotic cell death in glioma cells. We also showed that CBD induced mitochondrial dysfunction and lethal mitophagy arrest, leading to autophagic cell death. Mechanistically, calcium flux induced by CBD through TRPV4 (transient receptor potential cation channel subfamily V member 4) activation played a key role in mitophagy initiation. We further confirmed TRPV4 levels correlated with both tumor grade and poor survival in glioma patients. Transcriptome analysis and other results demonstrated that ER stress and the ATF4-DDIT3-TRIB3-AKT-MTOR axis downstream of TRPV4 were involved in CBD-induced mitophagy in glioma cells. Lastly, CBD and temozolomide combination therapy in patient-derived neurosphere cultures and mouse orthotopic models showed significant synergistic effect in both controlling tumor size and improving survival. Altogether, these findings showed for the first time that the antitumor effect of CBD in glioma is caused by lethal mitophagy and identified TRPV4 as a molecular target and potential biomarker of CBD in glioma. Given the low toxicity and high tolerability of CBD, we therefore propose CBD should be tested clinically for glioma, both alone and in combination with temozolomide. <b>Abbreviations</b>: 4-PBA: 4-phenylbutyrate; AKT: AKT serine/threonine kinase; ATF4: activating transcription factor 4; Baf-A1: bafilomycin A<sub>1</sub>; CANX: calnexin; CASP3: caspase 3; CAT: catalase; CBD: cannabidiol; CQ: chloroquine; DDIT3: DNA damage inducible transcript 3; ER: endoplasmic reticulum; GBM: glioblastoma multiforme; GFP: green fluorescent protein; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; SLC8A1: solute carrier family 8 member A1; SQSTM1: sequestosome 1; TCGA: The cancer genome atlas; TEM: transmission electron microscopy; TMZ: temozolomide; TRIB3: tribbles pseudokinase 3; TRPC: transient receptor potential cation channel subfamily C; TRPV4: transient receptor potential cation channel subfamily V member 4
DOI: 10.6084/m9.figshare.20406694
title: Rapid assessment of interfacial stabilization mechanisms of metastable precipitates to accelerate high-temperature Al-alloy development

description: Precipitate strengthened high-temperature alloys are currently used in safety-critical applications. Understanding precipitate stability and solute segregation mechanisms at high temperatures is key to designing high-strength alloys. Rapid <i>in-situ</i> approaches, therefore, are pivotal in accelerating the alloy design process. Hereby using the test case of a promising high-temperature Al-Cu-Mn-Zr alloy, we demonstrate the value of <i>in-situ</i> atom probe tomography coupled with <i>in-situ</i> transmission electron microscopy to reveal atomic-scale mechanisms that lead to the emergence of non-equilibrium solute segregation. Mn and Zr segregation at strengthening precipitate(<i>θ’)</i>-matrix interface increases the kinetic barrier for phase transformation thus retaining high-temperature strength. Our rapid approach can essentially eliminate lengthy heat treatments, metallographic preparations, and ex-situ characterization steps and thus help accelerate the process of high-temperature alloy design.
DOI: 10.6084/m9.figshare.20406694.v1
title: Rapid assessment of interfacial stabilization mechanisms of metastable precipitates to accelerate high-temperature Al-alloy development

description: Precipitate strengthened high-temperature alloys are currently used in safety-critical applications. Understanding precipitate stability and solute segregation mechanisms at high temperatures is key to designing high-strength alloys. Rapid <i>in-situ</i> approaches, therefore, are pivotal in accelerating the alloy design process. Hereby using the test case of a promising high-temperature Al-Cu-Mn-Zr alloy, we demonstrate the value of <i>in-situ</i> atom probe tomography coupled with <i>in-situ</i> transmission electron microscopy to reveal atomic-scale mechanisms that lead to the emergence of non-equilibrium solute segregation. Mn and Zr segregation at strengthening precipitate(<i>θ’)</i>-matrix interface increases the kinetic barrier for phase transformation thus retaining high-temperature strength. Our rapid approach can essentially eliminate lengthy heat treatments, metallographic preparations, and ex-situ characterization steps and thus help accelerate the process of high-temperature alloy design.
DOI: 10.6084/m9.figshare.14115239.v1
title: Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

description: Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against glioma; however, the molecular target and mechanism of action of CBD in glioma are poorly understood. Here we investigated the molecular mechanisms underlying the antitumor effect of CBD in preclinical models of human glioma. Our results showed that CBD induced autophagic rather than apoptotic cell death in glioma cells. We also showed that CBD induced mitochondrial dysfunction and lethal mitophagy arrest, leading to autophagic cell death. Mechanistically, calcium flux induced by CBD through TRPV4 (transient receptor potential cation channel subfamily V member 4) activation played a key role in mitophagy initiation. We further confirmed TRPV4 levels correlated with both tumor grade and poor survival in glioma patients. Transcriptome analysis and other results demonstrated that ER stress and the ATF4-DDIT3-TRIB3-AKT-MTOR axis downstream of TRPV4 were involved in CBD-induced mitophagy in glioma cells. Lastly, CBD and temozolomide combination therapy in patient-derived neurosphere cultures and mouse orthotopic models showed significant synergistic effect in both controlling tumor size and improving survival. Altogether, these findings showed for the first time that the antitumor effect of CBD in glioma is caused by lethal mitophagy and identified TRPV4 as a molecular target and potential biomarker of CBD in glioma. Given the low toxicity and high tolerability of CBD, we therefore propose CBD should be tested clinically for glioma, both alone and in combination with temozolomide. <b>Abbreviations</b>: 4-PBA: 4-phenylbutyrate; AKT: AKT serine/threonine kinase; ATF4: activating transcription factor 4; Baf-A1: bafilomycin A<sub>1</sub>; CANX: calnexin; CASP3: caspase 3; CAT: catalase; CBD: cannabidiol; CQ: chloroquine; DDIT3: DNA damage inducible transcript 3; ER: endoplasmic reticulum; GBM: glioblastoma multiforme; GFP: green fluorescent protein; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; SLC8A1: solute carrier family 8 member A1; SQSTM1: sequestosome 1; TCGA: The cancer genome atlas; TEM: transmission electron microscopy; TMZ: temozolomide; TRIB3: tribbles pseudokinase 3; TRPC: transient receptor potential cation channel subfamily C; TRPV4: transient receptor potential cation channel subfamily V member 4
DOI: 10.6084/m9.figshare.12018132
title: Lattice Boltzmann method for shallow water flow with wave radiation stress

description: The protection of the marine environment is of growing concern, and the development of hydrodynamic models is required to study ocean processes. In this work, a two-dimensional hydrodynamic lattice Boltzmann model was developed to study wave–current coupling problems that combine wave radiation, bed shear stress and wind shear stress. The model is based on nonlinear shallow water equations and two different forms are developed to model wave radiation stress. The first form uses an additional external force term, including a weight factor in the lattice Boltzmann equation at the streaming step. The second form modifies a local equilibrium distribution function at the collision step. Von Neumann stability method is used to study the two schemes. This model was verified by three classic cases: waves diffracted by a straight vertical wall, waves diffracted by two breakwaters, and waves in a circular channel. The numerical results demonstrate the validity of the proposed model, indicating that it can accurately describe the characteristics of water flow with interactions between waves and currents.
DOI: 10.6084/m9.figshare.12018132.v1
title: Lattice Boltzmann method for shallow water flow with wave radiation stress

description: The protection of the marine environment is of growing concern, and the development of hydrodynamic models is required to study ocean processes. In this work, a two-dimensional hydrodynamic lattice Boltzmann model was developed to study wave–current coupling problems that combine wave radiation, bed shear stress and wind shear stress. The model is based on nonlinear shallow water equations and two different forms are developed to model wave radiation stress. The first form uses an additional external force term, including a weight factor in the lattice Boltzmann equation at the streaming step. The second form modifies a local equilibrium distribution function at the collision step. Von Neumann stability method is used to study the two schemes. This model was verified by three classic cases: waves diffracted by a straight vertical wall, waves diffracted by two breakwaters, and waves in a circular channel. The numerical results demonstrate the validity of the proposed model, indicating that it can accurately describe the characteristics of water flow with interactions between waves and currents.
DOI: 10.6084/m9.figshare.15163878
title: Excavating the pathogenic gene of breast cancer based on high throughput data of tumor and somatic reprogramming

description: Breast cancer (BC) is one of the most common malignancies in female, and has a high mortality rate. The mechanisms of tumorigenesis and reprogramming of somatic cells have a certain degree of similarity. Here, we focus on the relationship between gene expression, signaling pathways and functions in BC compared to induced pluripotent stem cells (iPSCs). We first identified differentially expressed genes (DEGs) common to BC and iPSCs in datasets from GEO and TCGA. We found 22 DEGs that were significantly associated with clinicopathological features and prognosis by performing Kaplan-Meier survival analysis and one-way ANOVA. The results of protein mass spectrometry of tumor stem cells (Mcfips) demonstrated that the proteins encoded by 8 of these DEGs were also differentially expressed. The functional enrichment analysis showed that most of the 30 DEGs were related to collagen and chromatin functions. Our results might offer targets for future studies into the mechanisms underlying tumor occurrence and progression, and our studies could provide valuable data for both basic research and clinical applications of BC.
DOI: 10.6084/m9.figshare.11493891
title: Spatiotemporal patterns of cladoceran community responses to water level variation in Haixi Lake, southwest China

description: Hydrological regulation of lakes has been increasingly practiced around the world, with significant ecological consequences. However, little is known on how lake regulation affects community organization and succession. Crustacean zooplankton play a central role in energy transfer along lake food webs because of their intermediate trophic level. Haixi Lake, a mesotrophic deep-water reservoir in southwest China, was a shallow lake by nature but underwent dam construction and reinforcement in 1957 and 1987–1990, respectively. We applied the sediment records of cladoceran remains in Haixi to uncover the spatial and temporal changes of cladoceran assemblages along a gradient of water depth by combining a spatial survey of 27 surface sediment samples with a temporal survey of a well-dated sediment core covering the last 2 centuries. Lake depth was identified to be a paramount factor in driving the temporal and spatial variation of cladoceran assemblages, which was dominated by planktonic cladocerans such as <i>Bosmina</i>. With increasing water levels, a significant loss of benthic cladocerans and species diversity was noted, as well as a long-term decrease in antennule lengths of bosminids. Specifically, a threshold water depth of ∼8 m was found, possibly linked to lake water thermal stability and littoral habitat coverage. Our results highlight that water level serves as a significant factor in structuring zooplankton species composition and body sizes and should be considered for sustainable water management in regulated inland waters.
DOI: 10.6084/m9.figshare.11493891.v1
title: Spatiotemporal patterns of cladoceran community responses to water level variation in Haixi Lake, southwest China

description: Hydrological regulation of lakes has been increasingly practiced around the world, with significant ecological consequences. However, little is known on how lake regulation affects community organization and succession. Crustacean zooplankton play a central role in energy transfer along lake food webs because of their intermediate trophic level. Haixi Lake, a mesotrophic deep-water reservoir in southwest China, was a shallow lake by nature but underwent dam construction and reinforcement in 1957 and 1987–1990, respectively. We applied the sediment records of cladoceran remains in Haixi to uncover the spatial and temporal changes of cladoceran assemblages along a gradient of water depth by combining a spatial survey of 27 surface sediment samples with a temporal survey of a well-dated sediment core covering the last 2 centuries. Lake depth was identified to be a paramount factor in driving the temporal and spatial variation of cladoceran assemblages, which was dominated by planktonic cladocerans such as <i>Bosmina</i>. With increasing water levels, a significant loss of benthic cladocerans and species diversity was noted, as well as a long-term decrease in antennule lengths of bosminids. Specifically, a threshold water depth of ∼8 m was found, possibly linked to lake water thermal stability and littoral habitat coverage. Our results highlight that water level serves as a significant factor in structuring zooplankton species composition and body sizes and should be considered for sustainable water management in regulated inland waters.
DOI: 10.6084/m9.figshare.15163878.v1
title: Excavating the pathogenic gene of breast cancer based on high throughput data of tumor and somatic reprogramming

description: Breast cancer (BC) is one of the most common malignancies in female, and has a high mortality rate. The mechanisms of tumorigenesis and reprogramming of somatic cells have a certain degree of similarity. Here, we focus on the relationship between gene expression, signaling pathways and functions in BC compared to induced pluripotent stem cells (iPSCs). We first identified differentially expressed genes (DEGs) common to BC and iPSCs in datasets from GEO and TCGA. We found 22 DEGs that were significantly associated with clinicopathological features and prognosis by performing Kaplan-Meier survival analysis and one-way ANOVA. The results of protein mass spectrometry of tumor stem cells (Mcfips) demonstrated that the proteins encoded by 8 of these DEGs were also differentially expressed. The functional enrichment analysis showed that most of the 30 DEGs were related to collagen and chromatin functions. Our results might offer targets for future studies into the mechanisms underlying tumor occurrence and progression, and our studies could provide valuable data for both basic research and clinical applications of BC.
DOI: 10.6084/m9.figshare.19358212
title: Survival Analysis via Ordinary Differential Equations

description: This article introduces an Ordinary Differential Equation (ODE) notion for survival analysis. The ODE notion not only provides a unified modeling framework, but more importantly, also enables the development of a widely applicable, scalable, and easy-to-implement procedure for estimation and inference. Specifically, the ODE modeling framework unifies many existing survival models, such as the proportional hazards model, the linear transformation model, the accelerated failure time model, and the time-varying coefficient model as special cases. The generality of the proposed framework serves as the foundation of a widely applicable estimation procedure. As an illustrative example, we develop a sieve maximum likelihood estimator for a general semiparametric class of ODE models. In comparison to existing estimation methods, the proposed procedure has advantages in terms of computational scalability and numerical stability. Moreover, to address unique theoretical challenges induced by the ODE notion, we establish a new general sieve M-theorem for bundled parameters and show that the proposed sieve estimator is consistent and asymptotically normal, and achieves the semiparametric efficiency bound. The finite sample performance of the proposed estimator is examined in simulation studies and a real-world data example. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.19358212.v1
title: Survival Analysis via Ordinary Differential Equations

description: This article introduces an Ordinary Differential Equation (ODE) notion for survival analysis. The ODE notion not only provides a unified modeling framework, but more importantly, also enables the development of a widely applicable, scalable, and easy-to-implement procedure for estimation and inference. Specifically, the ODE modeling framework unifies many existing survival models, such as the proportional hazards model, the linear transformation model, the accelerated failure time model, and the time-varying coefficient model as special cases. The generality of the proposed framework serves as the foundation of a widely applicable estimation procedure. As an illustrative example, we develop a sieve maximum likelihood estimator for a general semiparametric class of ODE models. In comparison to existing estimation methods, the proposed procedure has advantages in terms of computational scalability and numerical stability. Moreover, to address unique theoretical challenges induced by the ODE notion, we establish a new general sieve M-theorem for bundled parameters and show that the proposed sieve estimator is consistent and asymptotically normal, and achieves the semiparametric efficiency bound. The finite sample performance of the proposed estimator is examined in simulation studies and a real-world data example. Supplementary materials for this article are available online.
DOI: 10.48597/sqtw-vsck
title: Inorganics in air and particle phase at Pallas (Matorova)

description: Measurement of Inorganics in air and particle phase at Pallas (Matorova)
DOI: 10.48597/t5ce-2hgg
title: Pm10_mass at Hohenpeissenberg

description: Measurement of Pm10_mass at Hohenpeissenberg
DOI: 10.48597/t92p-pnvr
title: PM mass at Auchencorth Moss

description: Measurement of PM mass at Auchencorth Moss
DOI: 10.48597/tesj-mt26
title: Aerosol light scattering at Melpitz

description: Measurement of Aerosol light scattering at Melpitz
DOI: 10.48597/tmhd-vxdz
title: Inorganics in air and particle phase at Rishiri

description: Measurement of Inorganics in air and particle phase at Rishiri
DOI: 10.48597/u365-xf5m
title: Inorganics in air and particle phase at Primorskaya

description: Measurement of Inorganics in air and particle phase at Primorskaya
DOI: 10.48597/u5uw-c8t8
title: Inorganics in air and particle phase at Oki

description: Measurement of Inorganics in air and particle phase at Oki
DOI: 10.48597/ub9p-hc7g
title: Precipitation_amount at K-puszta

description: Measurement of Precipitation_amount at K-puszta
DOI: 10.48597/upuh-73gr
title: Particle_number_size_distribution at Aspvreten

description: Measurement of Particle_number_size_distribution at Aspvreten
DOI: 10.48597/uthq-ygkh
title: Pm25_mass at Auchencorth Moss

description: Measurement of Pm25_mass at Auchencorth Moss
DOI: 10.48597/v7q4-tnpg
title: Particle_number_size_distribution at Pallas (Sammaltunturi)

description: Measurement of Particle_number_size_distribution at Pallas (Sammaltunturi)