cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19660614.v2
title: Prepared species distributions

description: Raster layers representing 31 species/population distributions that were prepared for: Johnson, C.A., Drever, R., Kirby, P. Neave, E. and Martin, A. E. Protecting boreal caribou habitat can help conserve biodiversity and safeguard large quantities of soil carbon in Canada See <strong>Read_me.pdf</strong> for full description. These prepared distributions were later combined with select distributions from the ‘Range map extents, species at risk, Canada’ dataset (ECCC, 2016) to estimate species richness, taxonomic diversity, and presence of species considered to be unique to the boreal caribou distribution. Most of the prepared distributions, provided here, were based on georeferencing maps/figures in status reports and hand digitizing the distribution. Others are based on assembling National Hydro Network work units to re-create distributions in status reports. Some distributions are based on convex hull generation around map features, similar to extent of occurrence boundaries. For hand digitized distributions, rather than tracing all shorelines, islands, administrative boundaries, or other features, some supplementary layers from the Atlas of Canada data sets were used (see Read_me.pdf: ‘Supporting layers, used in species distribution preparation’ section for layers used). <strong>NOTE</strong>: These distributions are not official representations of any given species or population. Many were heavily generalized in the source maps. Additional spatial error was introduced during map georeferencing and digitizing. <br> <br>
DOI: 10.17632/jpbnkh4dbs
title: Human Enjoyment in Tactile Interaction with Horses and Dogs: A Comparative Study

description: Animal-assisted interventions (AAI) are increasingly being integrated into human healthcare services due to their demonstrated positive impacts on mental and physical health. This research involved two separate experiments with 10 therapy horses and 18 therapy dogs. In both studies, the effect of touch treatments was assessed on human heart rate (HR), heart rate variability (HRV) and positive emotional responses evaluated by the Positive Affect Scale (PAS) survey representing three categories: activated, relaxed and safe. The experiment involving horses also explored the effect of human experience with horses on human HR, HRV and PAS categories. Forty-nine human participants interacted with horses (4/participant), and 44 participants interacted with dogs (1-4/participant) individually. The interactions occurred under two treatments: forced touch (animals were restricted and required to interact) and consensual touch (animals were free and could voluntarily choose to interact). Each participant's HR and HRV were recorded using a heart rate monitor. Each horse was equipped with a heart rate monitor. After each treatment, participants completed the PAS survey on a scale of 1-5, where 1 indicated “did not feel this way at all” and 5 indicated “felt this way very much”. A GLIMMIX model with repeated measures was used for statistical analysis, and Pearson correlations analyzed the relationship between human and horse HR. During forced touch interactions with horses, human HR was higher (p = .0001) and HRV (p = .0065) was lower compared to consensual touch interactions. Human experience with horses did not affect HR (p = .3043) or HRV (p = .1366) during human-horse touch interactions, but it did influence responses on the PAS survey, with more experienced participants reporting a lower "activated" (p = .0058) and higher "relaxed" (p = .0275) and "safe" (p = .0343) feelings compared to participants with less horse experience. No correlation was determined between human and horse HR (r = 0.09). In the dog study, human HR (p = .2513) and HRV (p = .1691) did not differ between the two touch treatments during human-dog interactions. Touch treatment did not influence PAS scores in either human-horse (all p &gt; .1373) or human-dog (all p &gt; .0953) touch treatments. Participants perceived interactions with dogs more positively than with horses, as indicated by the descriptive comparison of PAS scores across the two studies. The findings suggest that providing horses with the choice to interact with humans may affect participants' cardiac arousal, while no such impact was observed in human cardiac responses during interactions with dogs. These findings indicate that the influence of choice on human response may vary depending on the animal species involved. Understanding the species-specific variations is crucial for maximizing the success and effectiveness of AAI programs
DOI: 10.17632/s4wpg8k7yc
title: FOXM1 affects oxidative stress, mitochondrial function, and the DNA damage response by regulating p21 in postovulatory aging oocytes

description: RNA-Seq data
DOI: 10.3535/7y5-m5d-1cz
title: Cephalopoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.11848284.v1
title: Confidence at 100% Replication Dataset and Code

description: This is the replication dataset for https://doi.org/10.1111/acem.13930
DOI: 10.6084/m9.figshare.14253896.v1
title: Additional file 2 of Changes in patient visits and diagnoses in a large academic center during the COVID-19 pandemic

description: Additional file 2: Supplement 2. All changes in diagnostic codes by ophthalmic subspecialty.
DOI: 10.3535/76g-ykx-cq5
title: Cephalopoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/9g4-00e-jvk
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/hx5jtyxtxr
title: Increased lactate secretion by cancer cells sustains non-cell-autonomous adaptive resistance to MET and EGFR targeted therapies. Apicella et al.

description: Microenvironment is known to influence cancer drug response and sustain resistance to therapies targeting receptor-tyrosine kinases. However if and how tumor microenvironment can be altered during treatment, contributing to resistance onset is not known. Here we show that, under prolonged treatment with tyrosine kinase inhibitors (TKIs), EGFR- or MET-addicted cancer cells displayed a metabolic shift towards increased glycolysis and lactate production. We identified secreted lactate as the key molecule able to instruct Cancer Associated Fibroblasts (CAFs) to produce Hepatocyte Growth Factor (HGF) in a NF-KB dependent manner. Increased HGF, activating MET-dependent signaling in cancer cells, sustained resistance to TKIs. Functional or pharmacological targeting of molecules involved in the lactate axis, such as lactate dehydrogenase or the lactate transporters MCT4 and MCT1, abrogated in vivo resistance, demonstrating the crucial role of this metabolite in the adaptive process. This non-cell-autonomous, adaptive resistance mechanism was observed in NSCLC patients progressed on EGFR TKIs, demonstrating the clinical relevance of our findings and opening novel scenarios in the challenge to drug resistance.
DOI: 10.17632/j5gd4ndd2g
title: Supplemental material for "Tildrakizumab efficacy, drug survival, and safety are comparable in patients with psoriasis with and without metabolic syndrome: Long-term results from two phase 3 randomized controlled studies (reSURFACE 1 and reSURFACE 2)"

description: Supplemental material for Lebwohl, et al., "Tildrakizumab efficacy, drug survival, and safety are comparable in patients with psoriasis with and without metabolic syndrome: Long-term results from two phase 3 randomized controlled studies (reSURFACE 1 and reSURFACE 2)," J Am Acad Dermatol, 2020
DOI: 10.3535/7cr-r03-7pe
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ddc-z3p-pap
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/znt-n61-2c0
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.25507327.v1
title: sciPlexGxE HPRT1 & MMR GxE Screens

description: HPRT1 & MMR GxE Screens from José L. McFaline-Figueroa, Sanjay Srivatsan, Andrew J. Hill, Molly Gasperini, Dana L. Jackson, Lauren Saunders, Silvia Domcke, Samuel G. Regalado, Paul Lazarchuck, Sarai Alvarez, Raymond J. Monnat, Jay Shendure, Cole Trapnell, "Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy", Cell Genomics, Volume 4, Issue 2, 2024, https://doi.org/10.1016/j.xgen.2023.100487. (https://www.sciencedirect.com/science/article/pii/S2666979X23003397)
DOI: 10.3535/480-1n6-kpb
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/774-73q-few
title: †Orthoceratoidea F. McCoy, 1844

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/t3f-w00-yx0
title: Gastropoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/xmw-gyn-e65
title: †Subulites Emmons, 1842

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.12949886.v1
title: A Core Competency Model for Clinical Informationists

description: This is a semi-processed data transcript from an interview with 10 librarianship professionals who provided CI services for at least 2 years in clinical settings and 12 clinicians who received CI services for at least 2 years to identify the competencies needed by clinical Informationist. Data were collected through semi-structured interviews. A qualitative content analysis led to the identification of 6 main categories and 25 subcategories. In this transcript, there are quotations from participants below each subcategory. Similar quotations have been removed.
DOI: 10.6084/m9.figshare.5718940.v1
title: Healthier Sairé: a intersectorial policy as a turning point for local equity

description: Abstract Public health studies see intersectoriality as a strategy to promote equity in addressing the social determinants of health. The municipality of Sairé, a member of the Healthy Pernambuco Municipalities Network (RPMS), stands out for its adoption of an intersectorial policy, named A Healthier Sairé. This present study examines how this policy has promoted local equity. It was a case study using a timeline to record critical events, analysis of documents, interviews and participant observation. Actor-Network Theory (ANT) was used as a theoretical reference, and showed how adoption of the municipal policy had been central in promoting local empowerment and equity. The results, based on the timeline, demonstrate that initially it was necessary to obtain a cognitive translation, conducted through the direct influence and responsibility of the RPMS, which facilitated a second, strategic translation, with the construction of a policy anchored on the municipal program - which is currently being translated logistically into concrete actions directed towards equity. Key factors in this process for promoting local equity were: the role of strategic leadership; the value given to training; and the retention and use of structures that had previously been built.
DOI: 10.6084/m9.figshare.8063768.v3
title: Fast Generalized Linear Models by Database Sampling and One-Step Polishing

description: In this article, I show how to fit a generalized linear model to <i>N</i> observations on <i>p</i> variables stored in a relational database, using one sampling query and one aggregation query, as long as N12+δ observations can be stored in memory, for some δ&gt;0. The resulting estimator is fully efficient and asymptotically equivalent to the maximum likelihood estimator, and so its variance can be estimated from the Fisher information in the usual way. A proof-of-concept implementation uses R with MonetDB and with SQLite, and could easily be adapted to other popular databases. I illustrate the approach with examples of taxi-trip data in New York City and factors related to car color in New Zealand. Supplementary materials for this article are available online.
DOI: 10.17632/6vd4jm5rnx
title: ADHERENCE OF HEAD AND NECK CANCER PATIENTS TO LASER PHOTOBIOMODULATION IN A PUBLIC HEALTH SERVICE

description: Evaluate the adherence of patients with head and neck cancer who underwent radiotherapy or not associated with chemotherapy to the preventive laser photobiomodulation protocol in a public health service. This project was submitted and approved by the Human Ethics. All patients were informed about the treatment proposal and purpose, as well as the possible risks and benefits of the study, and signed the Informed Consent Form (ICF), which stated that they understood the purpose of the research and the proposed treatment, following the criteria of resolution 466/12 of the National Health Council. This was a cross-sectional study whose population sample who had not yet started cancer treatment, through free demand. The study included individuals with head and neck malignant tumors who had not initiated the proposed treatment protocol (radiotherapy with or without chemotherapy), with a minimum age of 18 at the beginning of the study and who had previous staging and tumor grade in their medical records. Data were collected regarding the type of cancer, its graduation and staging, patient’s proposed treatment, dose and number of sessions. A preventive laser photobiomodulation protocol was performed from the first session of radiotherapy. In order to monitor the development of oral mucositis, a form was given to patients so that they could make notes of the initial clinical manifestations. Once reported and verified the appearance of the first lesion, the patients continued to be attended by the Dental Service for laser application. Laser photobiomodulation used in the present study was a semiconductor diode, Twin Flex® (MM Optics, São Carlos, Brazil), 86.7 mW, device’s active tip area of 0.1256 cm2, 660 nm, which was applied at specific and equidistant points throughout the oral mucosa. The dosimetry used at each application point is described in the literature (2J / cm2), through a period of 10 seconds (Zecha et al., 2015). Preventive laser photobiomodulation was performed in 28 equidistant points in the oral cavity, excluding the tumor site. Patients presented 3 times a week, over a period of 3 weeks. In cases of development of grade III and IV mucositis, according WHO criteria, the laser protocol changed from preventive to curative. The same standard dosimetry was used. However, the active laser tip was directed to the ulcer edges so that the energy density was distributed at equidistant points throughout the contour of this lesion. For data collection and analysis, Microsoft Excel software was used to develop a spreadsheet, built specifically for the study. Regarding the qualitative variables (gender, origin, medical and dental history and frequency of attendance at photobiomodulatory therapy sessions), the data were obtained from a one-dimensional frequency table, from which their respective percentages were identified. Pearson's Chi-Square and Fisher's exact tests were used. The significance level considered for this study was p &lt;0.05.
DOI: 10.3535/4re-f3j-k6d
title: Gastropoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.11410122.v2
title: The relationship between anthropogenic light and noise in U.S. National Parks

description: Noise and light pollution in 270*270 m pixels in each National Park across the continental United States. Also included are important landscape factors that may influence noise and light levels in parks.
DOI: 10.17632/4sxj4t7vr6
title: Sex differences in auditory function of the desert locust

description: Analysed datafile (excel) and code (RScript) for transduction currents and electrophysiological properties for Figure 2 of paper: Sex differences in auditory function of the desert locust
DOI: 10.3535/9ww-1a0-aac
title: †Trilobita

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/kf9-2jn-pkv
title: Brachiopoda Duméril, 1805

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/pl6-2cw-67m
title: †Subulites Emmons, 1842

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/hsddc6nmzw
title: Organ-specific Immunity: A Tissue Analysis Framework for Investigating Local Immune Responses to SARS-CoV-2. Ng et al.

description: 53 regions-of-interest (ROIs) of spatial transcript data (21 lung, 32 Gut). Each ROI is scaled to have the same 75th percentile (Q3 normalization), and genes that fall below limit of detection in more than 85% of ROIs are not included.
DOI: 10.3535/t10-7fz-j52
title: Gastropoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ybg-cm0-eef
title: Gastropoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.5607841.v1
title: Machine Learning approach to rupture dynamics

description: The deformation-related energy budget is usually considered in the simplest form or even completely omitted from the energy balance equation. We derive a full energy balance equation that accounts not only for heat energy but also for mechanical (elastic, plastic and viscous) work. The derived equation is implemented in DES3D, an unstructured finite element solver for long-term tectonic deformation. We verify the implementation by comparing numerical solutions to the corresponding semi-analytic solutions in three benchmarks extended from the classical oedometer test. Two of the benchmarks are designed to evaluate the temperature change in a Mohr-Coulomb elasto-plastic square governed by a simplified equation involving plastic power only and by the full temperature evolution equation, respectively. The third benchmark differs in that it computes thermal stresses associated with a prescribed uniform temperature increase. All the solutions from DES3D show relative errors less than 0.1 \%. We also investigate the long-term effects of deformation energetics on the evolution of large offset normal faults.We find that the models considering the full energy balance equation tend to produce more secondary faults and an elongated core complex. Our results for the normal fault system confirm that persistent inelastic deformation has significant impact on the long-term evolution of faults, motivating further exploration of the role of the full energy balance equation in other geodynamic systems.
DOI: 10.3535/fsw-enz-ljk
title: Gastropoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.6084/m9.figshare.20459172.v3
title: Supplemental file 6_GOBP_VSMC_LgVSmall.csv

description: GO BP pathway analysis between large and small arteries in rat mesenteric arteries (smooth muscle cells)
DOI: 10.6084/m9.figshare.25497445.v1
title: <b>A deep</b><b> </b><b>learning framework </b><b>for </b><b><i>in silico</i></b><b> screening of anticancer drugs at the single-cell level</b>

description: Tumor heterogeneity plays a pivotal role in tumor progression and resistance to clinical treatment. Single-cell RNA sequencing (scRNA-seq) enables us to understand heterogeneity within a cell population and identify rare cell types, thus improving our understanding of tumor progression and revealing therapeutic strategies. Here, we profile a pan-cancer single-cell transcriptional landscape, revealing heterogeneous expression patterns within malignant cells, precancerous cells, as well as cancer-associated stromal and endothelial cells. We introduce a deep learning framework named Shennong for <i>in silico</i> screening of anticancer drugs at the single-cell level. By applying Shennong to our pan-cancer landscape, we could infer potential patient-specific anticancer drugs and their targets, while predicting corresponding side effects. This robust and explainable framework may accelerate the drug discovery process and enhances the accuracy and efficiency of drug screening.
DOI: 10.17632/5p46ych7fz
title: Requirements Levels 

description: Variables requirements levels from IFC/CItyGML3.0- based LoIN : 
3D variables can be obtained from BIM, CIM or other data external sources. For each data source, integration workflows should be developed to retrieve the precise information. For each scale of the analysis (building or city or both), the degree of granularity should consider the smallest part/element of the model that holds significant information for simulating the property value (Biljecki et al, 2015). For example, indoor sunlight requires attributes at the level of IFC (ifcspace) and the value is stored in a CityGML class (Room). 


Figure 3: Variables specifications based LoIN - variables examples: Indoor (e.g., Property cost), Interactive (e.g., Indoor daylight, Sunlight exposure) and Outdoor (e.g., View quality) (italic: spatial elements; bold: non-spatial elements)( El Yamani et al. 2021).
In the following, we propose two information specification levels for property valuation, named LoIN-1 and LoIN-2, for  property valuation, which are described below.

•	LoIN-1 :
The specifications at this stage focus on the fundamental and generic entities and attributes that are necessary in any initial step for property valuation simulation and modeling. One such example is the Property Unit, which has boundaries that are required for defining other variables. The Property Unit can be defined as a boundary of space, volume, or building elements, and it can be obtained from either the IFC building elements or the IfcSpace (see this link for tables details).

•	LoIN-2 :
At the second level of the approach, detailed information is obtained for each variable by analyzing the input/output specifications of entities, attributes/Pset_properties, or relationships. The IFC/CityGML schema is used to select relevant classes or subclasses to retrieve the required varia-bles. 
The Pset_properties, which are attributes generated during the building modeling process according to IFC schema specifications, are used to provide more comprehensive information for each varia-ble. For instance, indoor daylight is modeled as a Pset_properties, which is created during the BIM modeling stage and is not exported as IFC parameters by default. This approach allows for a more granular and accurate simulation of 3D property valuation variables.(see this link for tables de-tails ).
DOI: 10.3535/h13-ese-9b8
title: †Subulites Emmons, 1842

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vbk-kgk-bc3
title: †Trilobita

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.17632/n9yrhhh3n8
title: Data for: Revising the Sweet chestnut (Castanea sativa Mill.) refugia history of the last glacial period with extended pollen and macrofossil evidence
DOI: 10.3535/f29-dsa-ch3
title: Gastropoda Cuvier, 1795

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/01w-8r3-ygw
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gpj-mh2-lt0
title: Platycladus Spach

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/kb8-6gn-vq5
title: †Leptaena Dalman, 1828

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.