cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5125717.v1
title: Supplementary Material for: Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention

description: <b><i>Aim:</i></b> It is difficult to reliably detect the earliest signs of Alzheimer's disease (AD)-associated cognitive impairment. Our aim was to compare 3 psychometric methods of identifying amnestic mild cognitive impairment (aMCI) in a middle-aged longitudinal cohort enriched for AD risk. <b><i>Methods:</i></b> Wisconsin Registry for Alzheimer's Prevention (WRAP) participants with 3 waves of cognitive assessment over approximately 6 years were coded as meeting each of 3 psychometric aMCI definitions: (a) ‘aMCI standard-baseline' used published norms to establish cutoffs for baseline performance; (b) ‘aMCI robust-baseline' applied WRAP-specific robust norms to baseline, and (c) ‘aMCI robust-multiwave' applied these robust norms across 3 waves of assessment. Each group was compared to a cognitively healthy subset. <b><i>Results:</i></b> Half the aMCI standard-baseline and one third of the aMCI robust-baseline group reverted to normal ranges at follow-up. Only the aMCI robust-multiwave method had an aMCI × age interaction showing significantly worse age-related memory declines in the aMCI group compared to the cognitively healthy group over 6 years of follow-up. <b><i>Conclusion:</i></b> Both cross-sectional methods showed instability over time, with many reverting to normal performance after baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late middle age is a critical step in improving prevention efforts.
DOI: 10.6084/m9.figshare.7171889.v1
title: Decline evidence from Historical collections as a tool for assessing the global pollination crisis

description: Data table containing raw estimates of pollinator changes over time and associated metadata from all published studies containing this data. For studies reporting different measures, each measure is reported in a different row.
DOI: 10.6084/m9.figshare.7629737.v1
title: test dataset

description: test
DOI: 10.17632/d8r9sz6yyz
title: Increases in humidity will intensify lethal hyperthermia risk for birds occupying humid lowlands

description: Measurements of body temperature, carbon dioxide production and evaporative water loss in trumpeter hornbills at various combinations of air temperature and humidity.
DOI: 10.17632/tgggwcmhyz
title: An Open Source Head-Fixation and Implant-Protection System for Mice

description: These files accompany the paper entitled "An Open Source Head-Fixation and Implant-Protection System for Mice" in HardwareX. We kindly ask that you cite our HardwareX paper if you use any of our files.

Here we present a suite of open source, customizable head fixation designs with standard variants including head-fix hardware as well as implant protection systems. 3D printable files are included as both .stl (for easy upload and printing with no modifications) as well as .sldprt (for modification in SolidWorks). Please note that ALL Headbar designs DO work with the same Headfix Mounting Hardware, for ease of integration. 

In this file repository you will find:
1)"Headfix Mounting Hardware V1.2" - these files correspond to the fork-like design in the Headfix Rig used to immobilize the Headbar affixed to the mouse's skull. This design works with ALL Headbar variants (e.g. V1.2, V3.1, V4.0). 

2) "Headbar V1.2" - these files correspond to the simplified Headbar design that does not have attachment points for the HeadHat. This design offers no implant protection. 

3) "Headbar V3.1" - these files correspond to a modified Headbar design that does have attachment points for the V3.1 HeadHat. This Headbar/HeadHat combination is appropriate for small electrode and cannula guide implants. 

4) "HeadHat V3.1" - these files are for the HeadHat V3.1 which clips onto the HeadbarV3.1 for the protection of implants

5) "V3.1_dimensions" - this is a .pdf file detailing dimensions of this HeadbarV3.1/HeadHat V3.1 combination.

6) "HeadbarV4.0" - these files correspond to a modified Headbardesign that does have attachment points for the V4.0 HeadHat. This design has a larger footprint than the other variants. This Headbar/HeadHat combination is appropriate for large electrode or other implants. 

7) "HeadHat V4.0" - these files are for the HeadHat V4.0 which clips onto the HeadbarV4.0 for the protection of implants

8) "V4.0_dimensions" - this is a .pdf file detailing dimensions of this HeadbarV4.0/HeadHat V4.0 combination.

9) "Headfix Base Drill Pattern" - this is a .pdf diagram detailing the four holes that will need to be made in the plastic base during assembly of the Headfix Rig in order to headfix an animal.
DOI: 10.17632/xkv89tbftc
title: Successional generation of functional multidiversity and ecosystem complexity - a dataset from the Ödenwinkel research platform

description: Dataset gathered during START-Project from 2019-2022 at the Ödenwinkel research platform, Austria. Information on the research platform: https://doi.org/10.5194/we-20-95-2020
Included datasets: 
- Plot metadata
- Soil nutrient content
- Soil temperature
- Arthropod survey
- Vegtation survey
- Bryophyte survey
- Soil bacterial OTU-table
- Soil fungal OTU-table
- Historical climate data from surrounding weather station
DOI: 10.6084/m9.figshare.11652342.v1
title: Additional file 5. English versions of Claim Evaluation Tools_tests administrated in Norway_2019

description: English versions of Claim Evaluation Tools_tests administrated in Norway_2019. These tests are not validated for use in English and should be used under the advice of the IHC network. See https://www.informedhealthchoices.org/ for more information.
DOI: 10.6084/m9.figshare.13604195.v1
title: 4i Dataset Gut et al.

description: Please cite original article: <br>https://doi.org/10.1126/science.aar7042
DOI: 10.6084/m9.figshare.19507561.v1
title: Supplementary Material for: Effectiveness of Intensively Applied Mirror Therapy in Older Patients with Post-Stroke Hemiplegia: A Preliminary Trial

description: <b><i>Introduction:</i></b> The present work was carried out to determine the effectiveness of neuromuscular stimulation triggered by mirror therapy (MT) in older patients with post-stroke hemiplegia by two different intervention protocols, either intensively or spaced. <b><i>Methods:</i></b> A preliminary trial conducted on Spanish rehabilitation centres was conducted. Forty older patients (&gt;70 years) with diagnosed post-stroke hemiplegia were randomly distributed to intensive intervention group (5 times/week for 6 weeks) or to spaced intervention group (3 times/week for 10 weeks), which underwent a similar number of MT sessions (<i>n</i> = 30). Muscle strength and activity were measured at baseline and at the end of treatment. Functional ability was also evaluated. <b><i>Results:</i></b> Although both interventions improved muscle activity parameters, intensive MT showed a significantly and statistically higher intervention effect on electromyographic activity (<i>p</i> &lt; 0.001) and muscle strength (<i>p</i> &lt; 0.001) than the spaced over time protocol. Attending to the Barthel Index scores, the effect on functionality was also greater in the intensive therapy group (<i>p</i> &lt; 0.001), although the functional improvement measured by the Fugl-Meyer test was similar (<i>p</i> = 0.235). The effect of the interventions was independent of age and clinical antecedents. <b><i>Conclusion:</i></b> Intensive MT appears to be more effective than a more spaced over time therapy; therefore, at least in the older adults, this treatment protocol should be recommended in the post-stroke recovery of these patients. Further studies will confirm with certainty whether this treatment is the most suitable guideline for to treat these patients.
DOI: 10.6084/m9.figshare.23945073.v2
title: Table S6: HN-score Data for All Mouse Genes

description: To evaluate the genes whose expression was altered by Heat stress, an index called the Heat-stress and Non-treatment score (HN-score) was calculated for each gene in human and mouse. The HN-score was calculated by subtracting the instances of genes classified as downregulated from those classified as upregulated. The HN-score were calculated using the script (https://github.com/no85j/hypoxia_code) registered on GitHub.
DOI: 10.6084/m9.figshare.24442423.v1
title: Marker Genes for immune deconvolution tools MCP-counter, xCell, EPIC, and quanTIseq

description: Marker Genes for immune deconvolution tools MCP-counter, xCell, EPIC, and quanTIseq
DOI: 10.6084/m9.figshare.24498955.v1
title: Source Data For cisDynet.

description: Chromatin accessibility sequencing has been widely used for uncovering genetic regulatory mechanisms and inferring gene regulatory networks. However, effectively integrating large-scale chromatin accessibility datasets has posed a significant challenge. This is due to the lack of a comprehensive end-to-end solution, as many existing tools primarily emphasize data pre-processing and overlook downstream analyses. To bridge this gap, we have introduced cisDynet, a holistic solution that combines streamlined data pre-processing using Snakemake and R functions with advanced downstream analysis capabilities. cisDynet excels in conventional data analyses, encompassing peak statistics, peak annotation, differential analysis, motif enrichment analysis, and more. Additionally, it allows to perform sophisticated data exploration such as tissue-specific peak identification, time-course data fitting, integration of RNA-seq data to establish peak-to-gene associations, constructing regulatory networks, and conducting enrichment analysis of GWAS variants. As a proof of concept, we applied cisDynet to re-analyze the comprehensive ATAC-seq datasets across various tissues from the ENCODE project. The analysis successfully delineated tissue-specific open chromatin regions (OCRs), established connections between OCRs and target genes, and effectively linked these discoveries with 1,861 GWAS variants. Furthermore, cisDynet was instrumental in dissecting the time-course open chromatin data of mouse embryonic development, revealing the dynamic behavior of OCRs over time and identifying key transcription factors governing differentiation trajectories. In summary, cisDynet offers researchers a user-friendly solution that minimizes the need for extensive coding, ensures the reproducibility of results, and greatly simplifies the exploration of epigenomic data.
DOI: 10.6084/m9.figshare.24855882.v2
title: Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion

description: Input data and results for the manuscript<i>Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion</i>Corresponding source code is available from GitHub: https://github.com/ComputationalBiomedicineGroup/iHetDescription of the files:01_processed.tar.xz: Preprocessed input data to be used by the source code provided on GitHubcontainers.tar.xz: Singularity containers providing dependencies for the analysisresults.tar.xz: Intermediate and Final output files generated by the computational analysis.
DOI: 10.6084/m9.figshare.25853446.v1
title: the compiled database of low-temperature thermochronology ages from the Tian Shan

description: The compiled database of low-temperature thermochronology ages uploaded here are used to reveal the temporal and spatial variations of the exhumation rates across the Tian Shan by using the inversion method, which are shown in the article "Two-stage exhumation, uplift, and basinward propagation of the Tian Shan during the late Cenozoic" authorized by Jiang Y.T. and the coauthors and published in the journal Earth-Science Reviews.
DOI: 10.6084/m9.figshare.29117933.v1
title: DFT files

description: DFT files of defect and perfect Ru.
DOI: 10.6084/m9.figshare.5373247.v1
title: Self-concept of mexican children with learning disorders

description: Seventy children between 8 and 11 years of age (34 female) from several elementary schools in Querétaro, México participated in this study. Forty-five children had an LD diagnosis (the LD group) and 25 children had good academic achievement (the GAA group). Our objective was to explore the relationship between self-concept and LD in Mexican children. Children with LD had percentiles lower than 10 in at least one subscale (reading, writing and/or mathematics) of the Infant Neuropsychological Scale for Children (ENI) (Matute, Rosselli, Ardila, & Ostrosky-Solis, 2005) and lower than 16 in at least another subscale. Six self-concept domains were evaluated with the Piers-Harris Self-Concept Scale.
DOI: 10.6084/m9.figshare.7322228.v2
title: GuacaMol Training SMILES

description: Training partition of dataset for the GuacaMol de novo design benchmarks.<br><br>This is a subset of molecules extracted from ChEMBL 24. For more information see https://www.ebi.ac.uk/chembl/<br>
DOI: 10.6084/m9.figshare.7678469.v1
title: Ivermectin and albendazole withdrawal period in goat milk

description: SUMMARY Theaimthis study was to determine the excretion profile of albendazole and ivermectin residues in milk from goats submitted to antiparasitic treatment. Twenty-four Brazilianmongrel lactating and pluriparous goats, maintained extensively on native pasture were orally treatedwith albendazole or ivermectin. Milk samples were collected before and after vermifuges application, in the days 0, 2, 3 e 4 to albendazole and 0, 3, 7, 14, 21, 28, 35 and 42 to ivermectin. The vermifuges residues were detected by high performance liquid cromatography with ultravioletdetector. The amount of residues contained in themilk was decreasing in function of time. The mean daily rates of decrease of albendazole residues were 63.34%, 40.18 and 100.0%, from the 2ndto the 4thday, respectively; on the 3rdday after treatment, 50% of the samples showed concentrations ≥ 47.61 μg.mL–1, and on the 4thday, no sample had albendazole residue. The amount excreted of ivermectin was similar between the 3rdand 21stday when all samples presented values ≥ 51.90 μg.mL-1; on the 35th day, 50% of the samples showed values above of recommended levels, and on the 42nd day, no sample had detectable ivermectin residue. In conclusion, the milk of Brazilian mongrel goats treated orally with albendazole or ivermectin does not contain its respective residues in detectable amounts from the 4th and 42nddays, respectively, after antiparasitic treatment.
DOI: 10.6084/m9.figshare.781246.v1
title: Hematology of Strigiformes

description: Raw data for the article: Laboratory Blood Analysis in Captive Strigiformes - Part I: Hematologic Reference Intervals and Agreement between Manual Blood Cell Counting Techniques Mélanie Ammersbach, DVM Hugues Beaufrère, Dr.Med.Vet., PhD, DABVP (Avian), DECZM (Avian) Annick Gionet Rollick, BSc Thomas Tully, DVM, MS, DABVP (Avian), DECZM (Avian)
DOI: 10.15482/usda.adc/1391716
title: Leptinotarsa decemlineata genome annotations v0.5.3
DOI: 10.17632/h9n62w5ycb
title: Nonlinear Transmission of International Financial Stress

description: This folder contains information and instructions to replicate results associated with Tuzcuoglu, K. (2024), Nonlinear Transmission of International Financial Stress, Economic Modelling.
DOI: 10.17632/vs2g9cdfx4
title: Data: Leino et al. 2024 - Pollution-related changes in nest microbiota: Implications for growth and fledging in three passerine birds

description: In our study titled ‘Pollution-related changes in nest microbiota: Implications for growth and fledging in three passerine birds’ (manuscript submitted in April 2024), we investigated the connections between metal pollution, bird nest microbiota, and bird fitness. 

The attached folder ‘Leino etal2024_Nest_Phyloseq_object_publ.zip’ contains an R-compatible phyloseq object with microbial reads data, taxonomy table, and sample metadata used in this study. A separate PDF 'Leino2024_Nest Phyloseq object clarifications' clarifies variable abbreviations used in the sample metadata.
DOI: 10.6084/m9.figshare.18881372.v3
title: iHypoxia: An Integrative Database of the Expression Dynamics of Proteins in Response to Hypoxia in Animals

description: we developed an integrated resource for the expression dynamics of proteins and candidate genes in response to hypoxia (iHypoxia), and this database contains 1629 expression events of 1215 proteins identified by low-throughput experiments (LTEs) and 456,852 quantitative expression events of 39,483 proteins identified by high-throughput experiments (HTEs) from five mammals that exhibit a response to hypoxia. Various experimental details such as the hypoxic experimental conditions, expression patterns, and samples were carefully collected and integrated. Furthermore, ~10,000 candidate genes were also integrated from diverse species inhabiting low oxygen environment. In addition, we conducted an orthologous search and identified 432,298 computationally detected proteins that may respond to hypoxia among 48 animals.
DOI: 10.6084/m9.figshare.21066901.v6
title: RGD1-CNHO Database

description: This reaction database is generated along with the manuscript "Comprehensive exploration of graphically defined reaction spaces". <br> Additional data files are provided here. The csv file named as RGD1CHNO_smiles.csv contains atom-mapped SMILES, activation energies, and enthalpies of formation for each reaction. The HDF5 file contains the geometry information and can be iterated by a python script from Github (https://github.com/zhaoqy1996/RGD1/parse_data.py). <br> An additional csv file (DFT_reaction_info.csv) is supplied to reproduce figures in the article.
DOI: 10.6084/m9.figshare.21397509.v1
title: VLT Sanger Sequencing

description: sanger sequencing ab1 and fasta files for vlt_111
DOI: 10.6084/m9.figshare.23268362.v1
title: Supplementary Material for: The Role of Intermittent Fasting and Dieting on Cognition in Adult Population: A Systematic Review of the Randomized Controlled Trials

description: <b><i>Objective:</i></b> A healthy diet is a modifiable risk factor that may impact cognition. A unique type of diet may include intermittent fasting (IF), an eating pattern in which individuals go extended periods with little or no meal intake, intervening with periods of normal food intake. IF has multiple health benefits including maintenance of blood glucose levels, reduction of insulin levels, depletion or reduction of glycogen stores, mobilization of fatty acids, and generation of ketones. IF has shown neuroprotective effects as it may lead to increased neurogenesis in the hippocampus, which may contribute to cognitive resilience. Diets including IF were examined as lifestyle modifications in the prevention and management of cognitive decline. <b><i>Methods:</i></b> A systematic literature search was conducted for randomized controlled trials (RCTs) which assessed the effect of dieting on cognitive functions in adults. <b><i>Results:</i></b> Dietary Approaches to Stop Hypertension (DASH), low-glycemic diets, and caloric restriction have shown improvement in cognitive function; however, there was a negative impact on problem-solving in those with comorbid cardiovascular disease. There is also contradictory evidence that caloric restriction and diet alone may not be sufficient for the improvement of cognitive functions and that exercise may have better efficacy on cognition. <b><i>Conclusion:</i></b> IF is considered a safe intervention, and no adverse effects were found in the reviewed studies; however, evidence is limited as there were only 9 low-quality RCTs that assessed the impact of IF on cognition. DASH, low-glycemic diets, and exercise may have effective roles in the management and prevention of cognitive decline, although further research is needed.
DOI: 10.6084/m9.figshare.25427758.v1
title: Risk-averse DA and RT based TH-HIES table 1 data.docx

description: Integrated energy system. Power system operation problems. Seasonal energy storage. Hydrogen hub.
DOI: 10.6084/m9.figshare.28093163.v1
title: Supplementary Material for: ISPAD Clinical Practice Consensus Guidelines 2024: Insulin and adjunctive treatments in children and adolescents with diabetes

description: 1. WHAT IS NEW OR DIFFERENT 
• Updated insulin treatment sections including new bolus and basal insulin formulations
• Updated recommendations on principles of intensive insulin treatment regimens including more intensive form of multiple daily injections with new generation faster acting insulins and ultra-long acting insulins, to achieve a high level of treatment personalization, better glycemia and empowerment for people with diabetes
• Review of the roles and rationales for new insulin analogs, biosimilars, and diabetes technology devices for insulin therapy in pediatric diabetology
• Summary of adjunctive medications used alongside insulin treatment that includes details on pramlintide, metformin, GLP-1 Receptor Agonists (GLP-1RA) and SGLT inhibitors.
• Key considerations with regards to access to insulin and affordability specifically innovative, multi-faceted approaches involving governments, healthcare providers, pharmaceutical companies, and advocacy groups to ensure that all persons with diabetes who need insulin can obtain it without financial hardship.
DOI: 10.6084/m9.figshare.28943522.v1
title: 2025-505-07-esnet-model.pt.zip

description: ESNet model weights file
DOI: 10.6084/m9.figshare.3811560.v1
title: repoDB Production Code

description: This figshare code set contains all R source code needed to full reproduce repoDB, including pre-processing all data sources, compiling the full repoDB database, as well as the source code for the repoDB R Shiny application.
DOI: 10.17632/5566d5mtd9
title: Collected data of water levels, waves, currents and suspended sediment concentration in west sea of Vietnamese Mekong Delta

description: Raw data in the manuscript by Nguyet-Minh Nguyen, Tu Duy Le, Hiep Van Pham, Hoang Thai Duong Vu, Sylvain Ouillon, Thanh Cong Nguyen to be submitted by Marine Geology as "Suspended sediment pattern along the Mekong Delta's west coast induced by strong southwest monsoon activities and extreme events".
Field investigations to collected data of water levels, waves, currents and suspended sediment concentration were conducted within the framework of the ViWat-project, which was funded by the Federal Ministry of Education and Research (BMBF, Germany, Grant number 02WCL1474A) and the Ministry of Science and Technology of Vietnam (ĐTĐL.CN-47/18).
DOI: 10.17632/hvzky7z99p
title: LBM

description: The different asymmetry of rainfall responses during radiative forcing increase and stabilization in RCP4.5 experiments
The climatology state, heat forcing and the model outputs of simulations in LBM
The details of files are shown in the README file.
DOI: 10.6084/m9.figshare.11473998.v2
title: MOESM9 of Multi-species annotation of transcriptome and chromatin structure in domesticated animals

description: Additional file 9 ATAC-seq peaks (coordinates, quantification, positional classification): the archive contains four folders, one for each species (bos_taurus, capra_hircus, gallus_gallus, sus_scrofa). Each folder contains the following six files:• mergedpeaks_allinfo_gn_frag.tsv• mergedpeaks_allinfo_tr_frag.tsv• mergedpeaks_allinfo_tr_ref.tsv• mergedpeaks_allinfo_gn_ref.tsv• mergedpeaks.peaknb.allexp.readnb.bed.readme.idx• mergedpeaks.peaknb.allexp.readnb.bed
DOI: 10.6084/m9.figshare.12599648.v1
title: Time-series parameters

description: This is a summary of results yielded in time series analyses (including three parameters: intercept, slope, autocorrelation).