cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20677121.v1
title: RESULTS OF THE SURGICAL TREATMENT OF ARTICULAR SCAPULAR FRACTURES

description: ABSTRACT Introduction: Scapular fractures are rare injuries and are often associated with high-energy trauma, with joint fractures accounting for only 15% of all scapular fractures. Surgical treatment is indicated for fractures with large deviations and with joint instability. Objective: This study evaluates the clinical and functional results after surgical treatment of scapular fractures. Methods: Eight patients with scapular fractures were surgically treated between 2013 and 2019. For indication for surgical treatment, mediolateral deviations, glenopolar angle, angular deviations and joint deviations greater than 4 mm were taken into account. Radiographic results of consolidation, range of motion, functional score and visual analogue pain scale were obtained. Results: In the mean follow-up of twenty-nine months (13-40 months), all patients presented fracture consolidation. The mean UCLA score was 29 points (with 75% good results and 25% moderate results). Regarding the range of motion, the mean elevation was 146° (ranging from 110° to 60°), lateral rotation of 62° (36-80°) and medial rotation at the level of T7 (T6-T10). The final VAS mean was 2.3. All patients returned to the pre-injury level at work. Conclusion: In this series of cases, surgical treatment of scapular articular fractures provided satisfactory results with low rates of complications, showing to be an option in selected cases of deviated fractures. Level of Evidence IV, Case Series.
DOI: 10.6084/m9.figshare.20677124
title: Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes

description: Abstract The study aimed to explore the influence of genetic polymorphisms in ANKK1 and DRD2 on the signs and symptoms of temporomandibular disorder (TMD) in construction workers. This cross-sectional study included only male subjects. All construction workers were healthy and over 18 years age. Illiterate workers and functionally illiterate workers were excluded. The diagnosis of TMD was established according to the Research Diagnostic Criteria for TMD (RDC/TMD). Genomic DNA was used to evaluate the genetic polymorphisms ANKK1 (rs1800497) and DRD2 (rs6275; rs6276) using Real-Time PCR. Chi-square or Fisher exact tests were used to evaluate genotypes and allele distribution among the studied phenotypes. The established alpha of this study was 5%. The sample included a total of 115 patients. The age of the patients ranged from 19 to 70 years (mean age 38.2; standard deviation 11.7). Chronic pain (87.7%), disc displacement (38.2%), and joint inflammation (26.9%) were the most frequently observed signs and symptoms. The genetic polymorphism rs6276 in DRD2 was associated with chronic pain (p=0.033). In conclusion, our study suggests that genetic polymorphisms in DRD2 and ANKK1 may influence TMD signs and symptoms in a group of male construction workers.
DOI: 10.6084/m9.figshare.20677124.v1
title: Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes

description: Abstract The study aimed to explore the influence of genetic polymorphisms in ANKK1 and DRD2 on the signs and symptoms of temporomandibular disorder (TMD) in construction workers. This cross-sectional study included only male subjects. All construction workers were healthy and over 18 years age. Illiterate workers and functionally illiterate workers were excluded. The diagnosis of TMD was established according to the Research Diagnostic Criteria for TMD (RDC/TMD). Genomic DNA was used to evaluate the genetic polymorphisms ANKK1 (rs1800497) and DRD2 (rs6275; rs6276) using Real-Time PCR. Chi-square or Fisher exact tests were used to evaluate genotypes and allele distribution among the studied phenotypes. The established alpha of this study was 5%. The sample included a total of 115 patients. The age of the patients ranged from 19 to 70 years (mean age 38.2; standard deviation 11.7). Chronic pain (87.7%), disc displacement (38.2%), and joint inflammation (26.9%) were the most frequently observed signs and symptoms. The genetic polymorphism rs6276 in DRD2 was associated with chronic pain (p=0.033). In conclusion, our study suggests that genetic polymorphisms in DRD2 and ANKK1 may influence TMD signs and symptoms in a group of male construction workers.
DOI: 10.6084/m9.figshare.20677127
title: Huguenots, Englishmen, pineapples: abolitionist associational movement and enslaved people in escape routes between Pernambuco and Ceará in the 1880s

description: ABSTRACT Using terms like Huguenots, Englishmen, and pineapples, abolitionists have concealed the identity of enslaved people that they were in escape routes across the Pernambuco’s Zona da Mata region, Recife, and abolitionist quilombos in Ceará. This article examines the emergence of an interprovincial abolitionist networking in the early 1880s and the growing movement of escaped slaves between 1884 and 1888. It focuses on clandestine and radical actions performed by the Clube do Cupim. It also takes into consideration some aspects of Clube’s memory in the post-abolition. The Club stood out amongst abolitionist associations in terms of social diversity and the capacity to engage free, liberated and enslaved workers in operations that caused impacts over slavery in the region.
DOI: 10.6084/m9.figshare.20677130
title: Impact of smoking on protein levels of beta-defensins in periodontal disease

description: Abstract Antimicrobial peptides (AMPs) are important components of the host response against invading pathogens. In addition to their direct antimicrobial activity, they can also participate in the immune system modulation. However, the role of AMPs in the etiopathogenesis of periodontal disease and the risk factors that may influence their expression in the oral cavity are not fully understood. The aim of this study was to determine the impact of smoking on beta-defensin (hBD) 1 and 2 levels analyzing samples from periodontitis patients. Fifty patients with periodontitis, 25 smokers and 25 non-smokers, and 20 periodontally healthy patients were recruited. After periodontal clinical evaluation, gingival crevicular fluid (GCF) samples were collected from healthy sites of patients without periodontal disease and from healthy and diseased sites of patients with periodontitis. Peptides quantification was performed by sandwich ELISA technique. Smokers showed reduced GCF hBD 1 levels and increased hBD 2 levels compared to non-smokers in diseased sites (p &lt;0.05). Higher levels of hBD 1 were observed in healthy sites of patients without periodontal disease than in healthy sites of patients with periodontitis (p&lt;0.0001). Diseased sites of non-smokers presented higher levels of hBD 2 than healthy sites (p &lt;0.05). These results reveal that protein levels of hBDs 1 and 2 can be impaired by cigarette smoking in the presence of periodontal disease.
DOI: 10.6084/m9.figshare.20677130.v1
title: Impact of smoking on protein levels of beta-defensins in periodontal disease

description: Abstract Antimicrobial peptides (AMPs) are important components of the host response against invading pathogens. In addition to their direct antimicrobial activity, they can also participate in the immune system modulation. However, the role of AMPs in the etiopathogenesis of periodontal disease and the risk factors that may influence their expression in the oral cavity are not fully understood. The aim of this study was to determine the impact of smoking on beta-defensin (hBD) 1 and 2 levels analyzing samples from periodontitis patients. Fifty patients with periodontitis, 25 smokers and 25 non-smokers, and 20 periodontally healthy patients were recruited. After periodontal clinical evaluation, gingival crevicular fluid (GCF) samples were collected from healthy sites of patients without periodontal disease and from healthy and diseased sites of patients with periodontitis. Peptides quantification was performed by sandwich ELISA technique. Smokers showed reduced GCF hBD 1 levels and increased hBD 2 levels compared to non-smokers in diseased sites (p &lt;0.05). Higher levels of hBD 1 were observed in healthy sites of patients without periodontal disease than in healthy sites of patients with periodontitis (p&lt;0.0001). Diseased sites of non-smokers presented higher levels of hBD 2 than healthy sites (p &lt;0.05). These results reveal that protein levels of hBDs 1 and 2 can be impaired by cigarette smoking in the presence of periodontal disease.
DOI: 10.6084/m9.figshare.20677132
title: Posterior reversible encephalopathy syndrome in the pediatric population: a pictorial essay

description: Abstract Posterior reversible encephalopathy syndrome (PRES) is a rare disease attributed to an increase in blood pressure that exceeds the autoregulatory capabilities of the cerebral vasculature, resulting in brain edema. Although PRES primarily affects adults, the pediatric population is also at risk. Radiologists must be aware of that risk because the imaging features on brain MRI are often atypical, especially in pediatric patients. Over a 6-year period, nine pediatric patients were diagnosed with PRES at our institution. Here, those patients are evaluated retrospectively regarding demographic characteristics, clinical profiles, imaging aspects, and outcomes. In this pictorial essay, we review the typical and atypical imaging findings of PRES in pediatric patients, demonstrating that it should be considered in patients with a clinical profile suggestive of the diagnosis, given that prompt, effective treatment is important for full recovery, thus avoiding major morbidity and mortality in such patients.
DOI: 10.6084/m9.figshare.20677132.v1
title: Posterior reversible encephalopathy syndrome in the pediatric population: a pictorial essay

description: Abstract Posterior reversible encephalopathy syndrome (PRES) is a rare disease attributed to an increase in blood pressure that exceeds the autoregulatory capabilities of the cerebral vasculature, resulting in brain edema. Although PRES primarily affects adults, the pediatric population is also at risk. Radiologists must be aware of that risk because the imaging features on brain MRI are often atypical, especially in pediatric patients. Over a 6-year period, nine pediatric patients were diagnosed with PRES at our institution. Here, those patients are evaluated retrospectively regarding demographic characteristics, clinical profiles, imaging aspects, and outcomes. In this pictorial essay, we review the typical and atypical imaging findings of PRES in pediatric patients, demonstrating that it should be considered in patients with a clinical profile suggestive of the diagnosis, given that prompt, effective treatment is important for full recovery, thus avoiding major morbidity and mortality in such patients.
DOI: 10.6084/m9.figshare.20677141
title: Growth Performance and Tibia Mineralization of Broiler Chickens Supplemented with a Liquid Extract of Humic Substances

description: ABSTRACT The objective of the study was to evaluate the productive, carcass, and tibia mineralization responses in broiler chickens supplemented with a liquid extract of humic substances (HS) in the drinking water. Chicks were housed in holding cages from 8-42 days of age and were randomly assigned to one of five increasing HS levels in the drinking water (0, 161, 322, 483, and 644 µg/L). At 21 and 42 days, to obtain carcass and tibia measurements half of the broilers were slaughtered. ANOVA and linear regression were used to analyze the data. The HS chemical composition and flat structures were estimated. At 21 days, increasing levels of HS in the drinking water resulted in a cubic response on breast weight (p&lt;0.05), tibia ashes percentage (p&lt;0.05) and tibia Ca percentage, as well as a linear increasing response (p&lt;0.05) on P percentage. HS elicited a quadratic response on the tibia DM percentage (p&lt;0.05), Ca content (p&lt;0.01), and P content (p&lt;0.05) at 42 days. The optimal HS supplementation level to achieve the highest tibia DM percentage, Ca and P content were 345.00, 322.46, and 347.75 µg/L, respectively. Increasing HS levels also resulted in a cubic response in tibia Ca (p&lt;0.05) and P percentage (p&lt;0.01). In conclusions, HS supplementation in drinking water improved bone mineralization in broiler chickens at 21 and 42 days of age.
DOI: 10.6084/m9.figshare.20677141.v1
title: Growth Performance and Tibia Mineralization of Broiler Chickens Supplemented with a Liquid Extract of Humic Substances

description: ABSTRACT The objective of the study was to evaluate the productive, carcass, and tibia mineralization responses in broiler chickens supplemented with a liquid extract of humic substances (HS) in the drinking water. Chicks were housed in holding cages from 8-42 days of age and were randomly assigned to one of five increasing HS levels in the drinking water (0, 161, 322, 483, and 644 µg/L). At 21 and 42 days, to obtain carcass and tibia measurements half of the broilers were slaughtered. ANOVA and linear regression were used to analyze the data. The HS chemical composition and flat structures were estimated. At 21 days, increasing levels of HS in the drinking water resulted in a cubic response on breast weight (p&lt;0.05), tibia ashes percentage (p&lt;0.05) and tibia Ca percentage, as well as a linear increasing response (p&lt;0.05) on P percentage. HS elicited a quadratic response on the tibia DM percentage (p&lt;0.05), Ca content (p&lt;0.01), and P content (p&lt;0.05) at 42 days. The optimal HS supplementation level to achieve the highest tibia DM percentage, Ca and P content were 345.00, 322.46, and 347.75 µg/L, respectively. Increasing HS levels also resulted in a cubic response in tibia Ca (p&lt;0.05) and P percentage (p&lt;0.01). In conclusions, HS supplementation in drinking water improved bone mineralization in broiler chickens at 21 and 42 days of age.
DOI: 10.6084/m9.figshare.20677147
title: A New Approach for Histamine Functionalized Nanoparticles as Sorbent Phase for Bar Adsorptive Microextraction (BAµE) and Determination of Parabens in Water by HPLC-DAD

description: In this study, for the first time, histamine-functionalized magnetic nanoparticles (HIS-MNP) were used as sorbent phase combined with bar adsorptive microextraction (BAµE) for the determination of methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP) in water samples by high performance liquid chromatography coupled with diode array detection (HPLC-DAD). Extraction and desorption conditions, including desorption time and solvent, ionic strength effect and extraction time, were investigated. The extractions were performed for 90 min, 30% of NaCl and sample pH 5. Desorption was carried out using 250 μL of acetonitrile:methanol (25:75 v/v) for 30 min. The limits of detection (LODs) were of 1.5 μg L-1 and limits of quantification (LOQs) were 5.0 μg L-1 for all analytes. The intra-day precision ranged from 1% for EP, PP and BP to 3% for MP, EP, PP and BP. The inter-day precision ranged from 3% for EP to 18% for BP. The relative recoveries varied from 81 to 125%, and relative standard deviations (RSD) ranged between 1 and 16%.
DOI: 10.6084/m9.figshare.20677147.v1
title: A New Approach for Histamine Functionalized Nanoparticles as Sorbent Phase for Bar Adsorptive Microextraction (BAµE) and Determination of Parabens in Water by HPLC-DAD

description: In this study, for the first time, histamine-functionalized magnetic nanoparticles (HIS-MNP) were used as sorbent phase combined with bar adsorptive microextraction (BAµE) for the determination of methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP) in water samples by high performance liquid chromatography coupled with diode array detection (HPLC-DAD). Extraction and desorption conditions, including desorption time and solvent, ionic strength effect and extraction time, were investigated. The extractions were performed for 90 min, 30% of NaCl and sample pH 5. Desorption was carried out using 250 μL of acetonitrile:methanol (25:75 v/v) for 30 min. The limits of detection (LODs) were of 1.5 μg L-1 and limits of quantification (LOQs) were 5.0 μg L-1 for all analytes. The intra-day precision ranged from 1% for EP, PP and BP to 3% for MP, EP, PP and BP. The inter-day precision ranged from 3% for EP to 18% for BP. The relative recoveries varied from 81 to 125%, and relative standard deviations (RSD) ranged between 1 and 16%.
DOI: 10.6084/m9.figshare.20677151
title: Imaging manifestations of von Hippel-Lindau disease: an illustrated guide focusing on abdominal manifestations

description: Abstract Von Hippel-Lindau (VHL) disease is a monogenic autosomal dominant disorder with germline mutations of the VHL anti-oncogene on the short arm of chromosome 3 (3p25-26). It affects 1:36,000-50,000 individuals, with a penetrance greater than 90% at 65 years of age. Although of variable onset and presentation, with pleiotropism even among members of the same family who share a specific mutation, VHL disease usually manifests initially in young adults. It predisposes to the development of benign and malignant tumors of the central nervous system (CNS) and visceral organs. The clinical diagnosis of VHL disease can be made in the following circumstances: a) in patients with a family history of the disease and at least one of the tumors characteristic of it (e.g., retinal or CNS hemangioblastomas, clear cell renal cell carcinoma, pancreatic neuroendocrine tumors, and endolymphatic sac tumors); b) in patients with two or more CNS hemangioblastomas; c) or in patients with a retinal or CNS hemangioblastoma plus at least one visceral tumor characteristic of the disease, excluding renal and epididymal cysts. Imaging plays an important role in the diagnosis and follow-up of patients with VHL disease. This pictorial essay presents characteristic images of abdominal manifestations of VHL disease-related tumors that all radiologists should be aware of.
DOI: 10.6084/m9.figshare.20677151.v1
title: Imaging manifestations of von Hippel-Lindau disease: an illustrated guide focusing on abdominal manifestations

description: Abstract Von Hippel-Lindau (VHL) disease is a monogenic autosomal dominant disorder with germline mutations of the VHL anti-oncogene on the short arm of chromosome 3 (3p25-26). It affects 1:36,000-50,000 individuals, with a penetrance greater than 90% at 65 years of age. Although of variable onset and presentation, with pleiotropism even among members of the same family who share a specific mutation, VHL disease usually manifests initially in young adults. It predisposes to the development of benign and malignant tumors of the central nervous system (CNS) and visceral organs. The clinical diagnosis of VHL disease can be made in the following circumstances: a) in patients with a family history of the disease and at least one of the tumors characteristic of it (e.g., retinal or CNS hemangioblastomas, clear cell renal cell carcinoma, pancreatic neuroendocrine tumors, and endolymphatic sac tumors); b) in patients with two or more CNS hemangioblastomas; c) or in patients with a retinal or CNS hemangioblastoma plus at least one visceral tumor characteristic of the disease, excluding renal and epididymal cysts. Imaging plays an important role in the diagnosis and follow-up of patients with VHL disease. This pictorial essay presents characteristic images of abdominal manifestations of VHL disease-related tumors that all radiologists should be aware of.
DOI: 10.6084/m9.figshare.20677163
title: EPIDEMIOLOGICAL PROFILE OF PROXIMAL FEMORAL FRACTURES IN OLDER ADULTS AT THE REGIONAL HOSPITAL IN COTIA - SP, BRAZIL

description: ABSTRACT Objective: To identify the epidemiological profile of older patients with proximal femoral fractures treated at the Hospital Regional de Cotia, SP - Brazil, and describe the nutritional status of these patients. Methods: Data were obtained from the electronic patient medical records from August 2020 to April 2021. The variables studied were age, gender, ethnicity, weight and height (for BMI calculation), and presence of comorbidities. Fracture circumstances were also assessed, including trauma mechanism, anatomical location, and treatment. Moreover, the nutritional profile of patients was assessed using the Mini Nutritional Assessment (MAN). Results: Most patients were white women, with a mean age of 80 years and an average BMI of 23.55 kg/m2. Almost all patients suffered the fracture at home and the most common comorbidities were systemic arterial hypertension, diabetes mellitus, and Alzheimer’s disease. Most patients were considered to be malnourished or at risk of malnutrition. Conclusion: The nutritional status of older adults seems to be directly related to the risk of proximal fractures of the femur. Level of Evidence II, Retrospective Study.
DOI: 10.6084/m9.figshare.20677163.v1
title: EPIDEMIOLOGICAL PROFILE OF PROXIMAL FEMORAL FRACTURES IN OLDER ADULTS AT THE REGIONAL HOSPITAL IN COTIA - SP, BRAZIL

description: ABSTRACT Objective: To identify the epidemiological profile of older patients with proximal femoral fractures treated at the Hospital Regional de Cotia, SP - Brazil, and describe the nutritional status of these patients. Methods: Data were obtained from the electronic patient medical records from August 2020 to April 2021. The variables studied were age, gender, ethnicity, weight and height (for BMI calculation), and presence of comorbidities. Fracture circumstances were also assessed, including trauma mechanism, anatomical location, and treatment. Moreover, the nutritional profile of patients was assessed using the Mini Nutritional Assessment (MAN). Results: Most patients were white women, with a mean age of 80 years and an average BMI of 23.55 kg/m2. Almost all patients suffered the fracture at home and the most common comorbidities were systemic arterial hypertension, diabetes mellitus, and Alzheimer’s disease. Most patients were considered to be malnourished or at risk of malnutrition. Conclusion: The nutritional status of older adults seems to be directly related to the risk of proximal fractures of the femur. Level of Evidence II, Retrospective Study.
DOI: 10.6084/m9.figshare.20677165
title: Synthesis and Molecular Modeling Study of Two Bromo-Dimethoxybenzaldehydes

description: This work describes the synthesis, molecular structure, and packaging of the compounds 6-bromo-2,3-dimethoxybenzaldehyde (6-BRB) and 5-bromo-2,3-dimethoxybenzaldehyde (5 BRB). Characterization in the solid-state was carried out by X-ray diffraction, and the analysis of the interactions was described by the Hirshfeld surface, which helps in understanding the effect of replacing the bromine position in the aromatic ring. Both compounds (6-BRB and 5-BRB) crystallized in the space group P21/c and are stabilized with C-HO interactions, but only the 6-BRB has a halogen-type interaction. Theoretical calculations, carried out by the density functional theory at the CAM-B3LYP/6-311++G(d,p) level of theory in gas phase, provided information on their electronic properties. The geometric properties were compared to experimental data, and the analyses of the frontier molecular orbitals and the molecular electrostatic potential (MEP) maps were obtained to predict the physical-chemical properties. The supramolecular arrangements were analyzed throughout complexation interactions and corrected by counterpoise method. Hyperconjugation energies were employed to examine the stability of the intermolecular interactions of the compounds. The interaction intensities were determined through the topological parameters obtained through the quantum theory of atoms in molecules model.