cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7615763.v2
title: Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health’s candidate drug EH301 in people with ALS (PALS). <i>Methods</i>: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS were recruited thanks to the collaboration of the Spanish Foundation for ALS Research (FUNDELA). Study participants were randomized to receive either EH301 or placebo and underwent evaluation for 4 months. Differences between EH301 and placebo-treated participants were evaluated based on standard clinical endpoints, including the revised ALS functional rating scale (ALSFRS-R), forced vital capacity (FVC), and the Medical Research Council (MRC) grading scale. <i>Results</i>: Compared to placebo, participants treated with EH301 demonstrated significant improvements in the ALSFRS-R score, pulmonary function, muscular strength, and in skeletal muscle/fat weight ratio. EH301 was shown to significantly slow the progression of ALS relative to placebo, and even showed improvements in several key outcome measures compared with baseline. <i>Conclusions</i>: This study provides evidence in support of the disease-modifying effects of EH301 for the treatment of ALS.
DOI: 10.6084/m9.figshare.7615763.v4
title: Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health’s candidate drug EH301 in people with ALS (PALS). <i>Methods</i>: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS were recruited thanks to the collaboration of the Spanish Foundation for ALS Research (FUNDELA). Study participants were randomized to receive either EH301 or placebo and underwent evaluation for 4 months. Differences between EH301 and placebo-treated participants were evaluated based on standard clinical endpoints, including the revised ALS functional rating scale (ALSFRS-R), forced vital capacity (FVC), and the Medical Research Council (MRC) grading scale. <i>Results</i>: Compared to placebo, participants treated with EH301 demonstrated significant improvements in the ALSFRS-R score, pulmonary function, muscular strength, and in skeletal muscle/fat weight ratio. EH301 was shown to significantly slow the progression of ALS relative to placebo, and even showed improvements in several key outcome measures compared with baseline. <i>Conclusions</i>: This study provides evidence in support of the disease-modifying effects of EH301 for the treatment of ALS. <b>Trial registration:</b>ClinicalTrials.gov identifier: NCT03489200.
DOI: 10.6084/m9.figshare.7615763.v3
title: Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health’s candidate drug EH301 in people with ALS (PALS). <i>Methods</i>: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS were recruited thanks to the collaboration of the Spanish Foundation for ALS Research (FUNDELA). Study participants were randomized to receive either EH301 or placebo and underwent evaluation for 4 months. Differences between EH301 and placebo-treated participants were evaluated based on standard clinical endpoints, including the revised ALS functional rating scale (ALSFRS-R), forced vital capacity (FVC), and the Medical Research Council (MRC) grading scale. <i>Results</i>: Compared to placebo, participants treated with EH301 demonstrated significant improvements in the ALSFRS-R score, pulmonary function, muscular strength, and in skeletal muscle/fat weight ratio. EH301 was shown to significantly slow the progression of ALS relative to placebo, and even showed improvements in several key outcome measures compared with baseline. <i>Conclusions</i>: This study provides evidence in support of the disease-modifying effects of EH301 for the treatment of ALS.
DOI: 10.7284/125048
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise EN578 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124984
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN578 using a Furuno GP-90D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124985
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN578 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7615709
title: Drosophila strain specific response to cisplatin neurotoxicity

description: <i>Drosophila melanogaster</i> has recently been developed as a simple, <i>in vivo</i>, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. <i>Drosophila</i> sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. <i>Drosophila</i> is a promising model with which to study the effect of genetics on sensitivity to CIPN.
DOI: 10.6084/m9.figshare.7615676
title: Two-sided role of estrogen on endometrial carcinogenesis: stimulator or suppressor?

description: Endometrial carcinoma (EC) often expresses estrogen receptors (ER), and the growth of EC is stimulated by estrogen. Therefore, EC is considered to be an estrogen-dependent tumor. However, the role of estrogen in endometrial carcinogenesis is somewhat unclear because the majority of EC occurs at peri- or post menopause when serum estrogen levels are generally decreased. In this article, we describe the double-edged role of estrogen in the genesis of EC, especially in terms of mismatch repair functions <i>in vitro</i> and <i>in vivo</i>, i.e. when serum estradiol (E2) levels are relatively low (approximately less than 90 pg/ml), and E2 enhance the carcinogenesis, whereas high E2 levels may suppress the carcinogenesis. This will deepen mechanistic insight into unopposed estrogen.
DOI: 10.6084/m9.figshare.7615676.v1
title: Two-sided role of estrogen on endometrial carcinogenesis: stimulator or suppressor?

description: Endometrial carcinoma (EC) often expresses estrogen receptors (ER), and the growth of EC is stimulated by estrogen. Therefore, EC is considered to be an estrogen-dependent tumor. However, the role of estrogen in endometrial carcinogenesis is somewhat unclear because the majority of EC occurs at peri- or post menopause when serum estrogen levels are generally decreased. In this article, we describe the double-edged role of estrogen in the genesis of EC, especially in terms of mismatch repair functions <i>in vitro</i> and <i>in vivo</i>, i.e. when serum estradiol (E2) levels are relatively low (approximately less than 90 pg/ml), and E2 enhance the carcinogenesis, whereas high E2 levels may suppress the carcinogenesis. This will deepen mechanistic insight into unopposed estrogen.
DOI: 10.6084/m9.figshare.7615709.v1
title: Drosophila strain specific response to cisplatin neurotoxicity

description: <i>Drosophila melanogaster</i> has recently been developed as a simple, <i>in vivo</i>, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. <i>Drosophila</i> sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. <i>Drosophila</i> is a promising model with which to study the effect of genetics on sensitivity to CIPN.
DOI: 10.7284/124988
title: Gyrocompass data collected during research cruise EN578 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124989
title: Gyrocompass data collected during research cruise EN578 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125093
title: Meteorological Station data collected during research cruise EN578 using a RM Young 26800 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125090
title: Radiometer data collected during research cruise EN578 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125136
title: Radiometer data collected during research cruise EN578 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7614362
title: Crop-weed competition changes the decomposition of soil organic matter fractions in the rhizosphere

description: Certain plant combinations can stimulate the mineralization of soil organic matter (SOM), thereby changing the storage of soil organic carbon and affecting the physical and chemical soil properties. The aim of this study was to evaluate whether competition between weeds and maize can stimulate SOM decomposition. Eight treatments were performed: monoculture of maize and weeds (<i>Amaranthus viridis, Bidens pilosa</i>, and <i>Ipomoea grandifolia</i>), maize in competition with weeds, and non-cultivated soil. During cultivation, the rhizosphere priming effect (RPE) on SOM was estimated. Additionally, at 60 days after planting, soil samples were collected to measure the C contents of particulate (POM) and mineral-associated (MAOM) organic matter. From the 43<sup>rd</sup> day of cultivation onwards, the coexistence between maize and <i>B. pilosa</i> led to the highest RPE values, while maize vs. <i>A. viridis</i> showed negative RPE. Maize vs. <i>A. viridis</i> and maize vs. <i>I. grandifolia</i> caused increase in MAOM-C and decreases in POM-C. <i>Ipomoea grandifolia</i> monoculture and maize vs. <i>B. pilosa</i> led to the highest MAOM-C losses and reduced POM-C compared to the non-cultivated soils. Here it is demonstrated that competition between maize and <i>B. pilosa</i> increases SOM mineralization, while competition between maize and <i>A. viridis</i> or <i>I. grandifolia</i> retards this process.
DOI: 10.7284/125060
title: TSG (Thermosalinograph) data collected during research cruise EN578 using a Sea-Bird SBE-45 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7614362.v1
title: Crop-weed competition changes the decomposition of soil organic matter fractions in the rhizosphere

description: Certain plant combinations can stimulate the mineralization of soil organic matter (SOM), thereby changing the storage of soil organic carbon and affecting the physical and chemical soil properties. The aim of this study was to evaluate whether competition between weeds and maize can stimulate SOM decomposition. Eight treatments were performed: monoculture of maize and weeds (<i>Amaranthus viridis, Bidens pilosa</i>, and <i>Ipomoea grandifolia</i>), maize in competition with weeds, and non-cultivated soil. During cultivation, the rhizosphere priming effect (RPE) on SOM was estimated. Additionally, at 60 days after planting, soil samples were collected to measure the C contents of particulate (POM) and mineral-associated (MAOM) organic matter. From the 43<sup>rd</sup> day of cultivation onwards, the coexistence between maize and <i>B. pilosa</i> led to the highest RPE values, while maize vs. <i>A. viridis</i> showed negative RPE. Maize vs. <i>A. viridis</i> and maize vs. <i>I. grandifolia</i> caused increase in MAOM-C and decreases in POM-C. <i>Ipomoea grandifolia</i> monoculture and maize vs. <i>B. pilosa</i> led to the highest MAOM-C losses and reduced POM-C compared to the non-cultivated soils. Here it is demonstrated that competition between maize and <i>B. pilosa</i> increases SOM mineralization, while competition between maize and <i>A. viridis</i> or <i>I. grandifolia</i> retards this process.
DOI: 10.7284/125061
title: TSG (Thermosalinograph) data collected during research cruise EN578 using a Sea-Bird SBE-21 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124993
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise EN579 using a Hawaii UHDAS instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125095
title: Anemometer data collected during research cruise EN579 using a RM Young 05103 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7614266
title: overtaking before reflection

description: One dimensional simulation where the rarefaction wave catches up to the forward shock before the latter reaches the back side of the target.<br>
DOI: 10.6084/m9.figshare.7614266.v1
title: overtaking before reflection

description: One dimensional simulation where the rarefaction wave catches up to the forward shock before the latter reaches the back side of the target.<br>
DOI: 10.7284/125096
title: Anemometer data collected during research cruise EN579 using a RM Young 05103 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125049
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise EN579 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124990
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN579 using a Furuno GP-90D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124991
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN579 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124994
title: Gyrocompass data collected during research cruise EN579 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.25377/sussex.7614197
title: External objects and computer code abstractions

description: —Digital Appendix / Documentation of the PhD Study: IM-Medea: Posthumanism and Remediation in Music Theatre.—<br>This is a collection of external Max/MSP objects and code abstractions that are used in many of the experiments of this PhD study. They will have to be installed separately from the experiment-specific computer code that can be found in each one of the 9 experiments.
DOI: 10.7284/124995
title: Gyrocompass data collected during research cruise EN579 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.5519/qd.bho6uk68
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.7284/125097
title: Meteorological Station data collected during research cruise EN579 using a RM Young 26800 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125094
title: Radiometer data collected during research cruise EN579 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7614140
title: Raw Data: Factors limiting sensitivity to binocular disparity in human vision

description: Data from 53 subjects in three experiments.<br>Experiment 1 (53 subjects): Four-alternative forced choice task where subjects viewed a field of black and white dots. They located which location (of four) contained a wedge-shaped target in either crossed or uncrossed disparity. Stimuli were presented for an unlimited duration.<br>Experiment 2 (18 subjects): As above but with stimulus duration reduced to 250 ms. Also, stimuli now contained disparity noise (standard deviation of 0 to 512 arc seconds) applied to each dot. This allowed us to measure noise-masking functions.<br>Experiment 3 (11 subjects): Control experiment with duration further reduced to 50 ms.
DOI: 10.7284/125137
title: Radiometer data collected during research cruise EN579 using a Eppley RAD instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/125062
title: TSG (Thermosalinograph) data collected during research cruise EN579 using a Sea-Bird SBE-45 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7614110
title: reflection before overtaking

description: One dimensional collision where the forward shock wave reflects from the back side of the target before the rarefaction overtakes it.<br>
DOI: 10.6084/m9.figshare.7614110.v1
title: reflection before overtaking

description: One dimensional collision where the forward shock wave reflects from the back side of the target before the rarefaction overtakes it.<br>
DOI: 10.7284/125063
title: TSG (Thermosalinograph) data collected during research cruise EN579 using a Sea-Bird SBE-21 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7614092
title: Delivery and feto-neonatal outcomes of diamniotic twin pregnancies in women with no chronic disease or gestational complications: impact of mode of conception

description: <b>Introduction:</b> Autologous and heterologous assisted reproductive technology (ART) conceptions have been on the rise for the last few decades and alongside with that have the rate of multiple pregnancies. Multiple gestations are associated with high odds of gestational complications and, in turn, adverse delivery and feto-neonatal outcomes. Whether ART-conception further increases such elevated risk is still debated. ART is more commonly accessed by older women with chronic diseases, which relate to heightened likelihood of complications. We decided to investigate the influence of autologous and heterologous ART conception compared to spontaneous conception on delivery and feto-neonatal outcomes of diamniotic twin pregnancies in a cohort of healthy women with no chronic conditions or gestational complications. <b>Materials and methods:</b> Retrospective cohort study among diamniotic twin pregnancies in mothers without pregestational or gestational disease. Delivery and feto-neonatal outcomes were compared among three groups according to mode of conception: (1) spontaneous conception (SC, referent group, <i>n</i> = 251 pregnancies), (2) autologous ART-conception (A-ART, <i>n</i> = 87), and (3) heterologous ART-conception (H-ART, <i>n</i> = 22). <b>Results:</b> At adjusted analyses, twin pregnancies conceived by A-ART showed a twofold heightened risk of delivery by urgent/emergent cesarean section, as well as four and sevenfold increase in odds of blood loss &gt;1000 and &gt;1500 mL, respectively. H-ART pregnancies were at fivefold higher risk of undergoing prelabor cesarean section compared to SC, whereas no differences were identified for odds of severe post-partum hemorrhage. Also, A-ART and H-ART gestations displayed fetal and neonatal outcomes similar to SC pregnancies when analysis was adjusted for relevant confounding factors. <b>Conclusion:</b> Our results suggest that both A-ART and H-ART conception associate with increased odds of operative delivery among diamniotic twin pregnancies in healthy mothers with no chronic diseases or gestational complications. Also, a higher risk of severe postpartum hemorrhage appears to relate to A-ART independent of mode of delivery and maternal age. Further studies with larger series of uncomplicated twin pregnancies are warranted to improve our understanding of the relationship of ART to adverse delivery outcomes.
DOI: 10.6084/m9.figshare.7614089
title: An <i>EnSpm</i> interspersed repeat identified in <i>Triticum aestivum</i> and implicated in resistance to <i>Diuraphis noxia</i>

description: <i>Diuraphis noxia</i> Kurdjumov, 1913 (Hemiptera: Aphididae), commonly known as the Russian wheat aphid, is a devastating pest of wheat and barley. Although fourteen sources of resistance (<i>Dn</i> genes) have been identified to date, none have been cloned. In this study a mapping population of 373 F<sub>3/4</sub> segregating wheat plants and ‘Chinese Spring’ 7D deletion lines were screened with AFLP, SSR and EST markers. From the marker screens, a 122.8 cM genetic map was constructed placing the <i>Dn1</i> resistance gene on chromosome 7DS near the centromere, in bin 7DS5-0.36-0.62 proportionally to the physical ‘Chinese Spring’ deletion 7D map. The map contains 38 new AFLP markers, one microsatellite (<i>Xgwm111</i>) and two EST markers. Of all the markers, AFLP E-ACT/M-CTG_0270.84 showed the closest linkage to <i>Dn1</i> and were mapped at 3.5 cM, whereas EST markers RGA2-29_30 and SSH-RGA2 were mapped at 15.3 cm and 15.9 cM, respectively, from <i>Dn1</i>. An AFLP marker, E-ACA/M-CAG-257, located 21.4 cM from the <i>Dn1</i> resistance gene, was successfully cloned and sequenced. The marker sequence was identified to belong to the interspersed repeat class of the subfamily CMC-EnSpm.