DOI: 10.6084/m9.figshare.24054636
title: Additional file 1 of A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis

description: Additional file 1: Table S1. The characteristic of sex hormone-binding globulin adjusted for BMI associated index SNPs, their effect sizes with exposure and outcome, as well as their associations with potential confounders. Table S2. The characteristic of sex hormone-binding globulin adjusted for BMI associated index SNPs in men, their effect sizes with exposure and outcome, as well as their associations with potential confounders. Table S3. The characteristic of sex hormone-binding globulin adjusted for BMI associated index SNPs in women, their effect sizes with exposure and outcome, as well as their associations with potential confounders. Table S4. The characteristic of crude sex hormone-binding globulin associated index SNPs, their effect sizes with exposure and outcome, as well as their associations with potential confounders. Table S5. The characteristic of crude sex hormone binding globulin associated index SNPs in men, their effect sizes with exposure and outcome, as well as their associations with potential confounders. Table S6. The characteristic of crude sex hormone-binding globulin associated index SNPs in women, their effect sizes with exposure and outcome, as well as their associations with potential confounders. Table S7. Cross-trait meta-analysis between sex hormone-binding globulin adjusted for BMI and rheumatoid arthritis, excluding the MHC region (PCPASSOC &lt; 5×10−8, PSHBGadjBMI &lt; 1×10−5 and PRA &lt; 1×10−5). Table S8. Cross-trait meta-analysis between crude sex hormone-binding globulin and rheumatoid arthritis, excluding the MHC region (PCPASSOC &lt; 5×10−8, PSHBG &lt; 1×10−5 and PRA &lt; 1×10−5). Table S9. Functional annotation of SNPs shared between sex hormone-binding globulin adjusted for BMI and rheumatoid arthritis identified from the cross-trait meta-analysis, excluding the MHC region. Table S10. Functional annotation of SNPs shared between crude sex hormone-binding globulin and rheumatoid arthritis identified from the cross-trait meta-analysis, excluding the MHC region. Table S11. List of 99% credible set SNPs in each sex hormone-binding globulin adjusted for BMI and rheumatoid arthritis shared locus identified from fine-mapping analysis (r2 threshold = 0.6). Table S12. Shared significant genes between sex hormone binding globulin adjusted for BMI and rheumatoid arthritis from transcriptome-wide association studies using gene expressions across 49 GTEx tissues. Table S13. Bidirectional causal associations between genetically predicted sex hormone-binding globulin levels and risk of rheumatoid arthritis. Table S14. Sensitivity analysis of causal association between genetically predicted sex hormone-binding globulin levels and risk of rheumatoid arthritis. Table S15. Causal association between sex hormone-binding globulin levels and risk of rheumatoid arthritis based on the robust adjusted profile score (RAPS). Table S16. Power calculation in assumed and actual OR in our study.