cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb2220577
title: Enhanced Solubilisation of Fragrances in Solutions of Sugar Surfactants in Natural Deep Eutectic Solvents (NADES)

description: Natural deep eutectic solvents (NADES) represent a novel class of renewable and biodegradable solvents. We wish to investigate the self-aggregation behaviour of selected sugar surfactants (based on glucose, lactose etc.) in NADES. Our NADES of choice is a 1:2 molar mixture of choline chloride and urea, named "reline". Interestingly, such solutions could solubilise fragrance molecules such as terpenes and alcohols. The focus of this experiment lies in the solubilisation of multiple fragrance compounds and their synergistic effect. The unique combination of NADES, sugar surfactants and natural fragrance compounds results in a formulation of water-free biodegradable microemulsions. We see the possible application in cosmetics and in pharmaceuticals. With the help of small-angle neutron scattering, our objective is to shed light on the structure and size of these aggregates in NADES.
DOI: 10.5286/isis.e.rb2220577-1
title: Enhanced Solubilisation of Fragrances in Solutions of Sugar Surfactants in Natural Deep Eutectic Solvents (NADES)

description: Natural deep eutectic solvents (NADES) represent a novel class of renewable and biodegradable solvents. We wish to investigate the self-aggregation behaviour of selected sugar surfactants (based on glucose, lactose etc.) in NADES. Our NADES of choice is a 1:2 molar mixture of choline chloride and urea, named "reline". Interestingly, such solutions could solubilise fragrance molecules such as terpenes and alcohols. The focus of this experiment lies in the solubilisation of multiple fragrance compounds and their synergistic effect. The unique combination of NADES, sugar surfactants and natural fragrance compounds results in a formulation of water-free biodegradable microemulsions. We see the possible application in cosmetics and in pharmaceuticals. With the help of small-angle neutron scattering, our objective is to shed light on the structure and size of these aggregates in NADES.
DOI: 10.3535/fr8-kc5-vgk
title: Valerianella echinata (L.) DC.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/y85-kw9-cve
title: Trigonella hierosolymitana Boiss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2210226-2
title: Manufacturing of permanent magnets by additive manufacturing: Establishing neutron imaging as an essential characterization tool

description: Here we propose combined Bragg edge and magnetic contrast-based neutron imaging which will allow to identify the distribution of the ferromagnetic phase in correlation with the distribution of the magnetic domains in additive manufactured MnAl permanent magnets. The results from this study will show the way for optimisation of the manufacturing parameters.
DOI: 10.5286/isis.e.rb2220387
title: Peptide-mediated lipid transport in lung surfactant models: increasing the complexity while lowering the surface tension

description: Synthetic therapies to treat infant respiratory distress syndrome are urgently needed, as current treatments have stringent storage conditions and are inaccessible in developing countries. We need to understand better how lung surfactant protein B (SP-B) transports lipid between vital lipid reservoirs (when breathing in) to the surface monolayer keeping surface tension close to zero (when breathing out). This proposal builds on a broader project and results from a neutron reflectometry experiment to increase the complexity of the lung surfactant model at more realistic low surface tension values of relevance to lung function. Novelty in the approach is not only the low surface tension but also the selective deuteration of different components of the lipid mixture to highlight the reservoir composition directly with respect to the presence of a peptide analogue of SP-B for the first time.
DOI: 10.5286/isis.e.rb2220387-1
title: Peptide-mediated lipid transport in lung surfactant models: increasing the complexity while lowering the surface tension

description: Synthetic therapies to treat infant respiratory distress syndrome are urgently needed, as current treatments have stringent storage conditions and are inaccessible in developing countries. We need to understand better how lung surfactant protein B (SP-B) transports lipid between vital lipid reservoirs (when breathing in) to the surface monolayer keeping surface tension close to zero (when breathing out). This proposal builds on a broader project and results from a neutron reflectometry experiment to increase the complexity of the lung surfactant model at more realistic low surface tension values of relevance to lung function. Novelty in the approach is not only the low surface tension but also the selective deuteration of different components of the lipid mixture to highlight the reservoir composition directly with respect to the presence of a peptide analogue of SP-B for the first time.
DOI: 10.34740/kaggle/dsv/12416847
title: Contrastive Language Image Pretraining by openai
DOI: 10.3535/bp7-jzp-4q0
title: Fumaria judaica Boiss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/szn-jqw-df7
title: Anthoxanthum odoratum L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2220278
title: Model thylakoid-type bilayer structural changes at the electrode surface

description: Thylakoid membranes in chloroplasts are the hosts of a high density of light-harvesting proteins responsible for the first step of photosynthesis. In some bioelectronic devices that tap into the ability of plants to harvest solar energy, thylakoid membranes are extracted and deposited onto electrode surfaces to act as biological solar panels. These devices are currently limited by slow electron-transfer between the membrane and electrode, but optimising this process is non-trivial, and the underlying structure of the deposited membrane is unclear. Here, we aim to use neutron reflectometry to characterise model thylakoid membranes in situ and hence relate structural changes to overall quantum yield for this promising renewable energy technology.
DOI: 10.5286/isis.e.rb2220278-1
title: Model thylakoid-type bilayer structural changes at the electrode surface

description: Thylakoid membranes in chloroplasts are the hosts of a high density of light-harvesting proteins responsible for the first step of photosynthesis. In some bioelectronic devices that tap into the ability of plants to harvest solar energy, thylakoid membranes are extracted and deposited onto electrode surfaces to act as biological solar panels. These devices are currently limited by slow electron-transfer between the membrane and electrode, but optimising this process is non-trivial, and the underlying structure of the deposited membrane is unclear. Here, we aim to use neutron reflectometry to characterise model thylakoid membranes in situ and hence relate structural changes to overall quantum yield for this promising renewable energy technology.
DOI: 10.5286/isis.e.rb2220625-2
title: Creep Cavitation in Copper

description: The key objectives are to study creep cavitation (formation of voids at high temperature) in pure copper. Cavities forming in polycrystalline materials leads to a drop in the toughness of materials. The results from this experiment will inform the creep cavity modelling work in our EPSRC project (EP/R02607/1) and will be submitted for publication in peer-reviewed scientific journals. Such studies will give insights on the creep cavity formation and coarsening in stainless steels used for power generation industries.
DOI: 10.3535/np1-133-dmb
title: Scutellaria brevibracteata Stapf

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/qgh-71h-jbq
title: Garidella unguicularis Poir.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2210116-1
title: Pd catalyst poisoning in the electro-oxidation of methanol and formic acid: A combined neutron scattering and modulation excitation study

description: A wide range of chemical processes involving liquid phase reactions within which a solvent is in excess compared with the reagents. This dilutes the concentration of the reactive species and can often lead to difficulties in observing them. We propose to examine the use of time resolved measurements where the system undergoes a periodic modulation to enhance the sensitivity of the techniques to examine the parts of the system which change versus the unchanging elements, i.e. the solvent. Herein, neutron scattering will be employed to probe the changes in structure of palladium based electrocatalysts for use in fuel cells for clean energy applications. The neutron scattering is complementary to recently obtained X-ray data and will enable the active structure of the working catalyst to be determined and therefore provide insights into developing more efficient catalysts in the future.
DOI: 10.5286/isis.e.rb2220625
title: Creep Cavitation in Copper

description: The key objectives are to study creep cavitation (formation of voids at high temperature) in pure copper. Cavities forming in polycrystalline materials leads to a drop in the toughness of materials. The results from this experiment will inform the creep cavity modelling work in our EPSRC project (EP/R02607/1) and will be submitted for publication in peer-reviewed scientific journals. Such studies will give insights on the creep cavity formation and coarsening in stainless steels used for power generation industries.
DOI: 10.3535/bzt-bem-j9y
title: Stellaria media (L.) Vill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/vwx-h0y-lzr
title: Ochthodium aegyptiacum (L.) DC.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2210116
title: Pd catalyst poisoning in the electro-oxidation of methanol and formic acid: A combined neutron scattering and modulation excitation study

description: A wide range of chemical processes involving liquid phase reactions within which a solvent is in excess compared with the reagents. This dilutes the concentration of the reactive species and can often lead to difficulties in observing them. We propose to examine the use of time resolved measurements where the system undergoes a periodic modulation to enhance the sensitivity of the techniques to examine the parts of the system which change versus the unchanging elements, i.e. the solvent. Herein, neutron scattering will be employed to probe the changes in structure of palladium based electrocatalysts for use in fuel cells for clean energy applications. The neutron scattering is complementary to recently obtained X-ray data and will enable the active structure of the working catalyst to be determined and therefore provide insights into developing more efficient catalysts in the future.
DOI: 10.5286/isis.e.rb2220322
title: Endosomal Interaction of Lipid Nanoparticles

description: There has been a shift in the pharma industry towards development of medicines containing therapeutic agents acting at sub-cellular compartments, thereby creating a demand for advanced delivery vehicles that convey their payload to the required site of action. A feature of intracellular delivery is that the vehicle is taken up by the target cells via endocytosis with the vehicle and its payload becoming engulfed in the endosome. In order for the therapeutic molecule to exert its effect, it must escape from the endosome. Neutron reflectometry coupled with contrast variation will help to unravel the interaction(s) between lipid nanoparticles (LNPs) carrying RNA and containing different ionisable lipids and the endosomal membrane (particularly the early stage endosomal membrane) to enable the design of efficient LNPs that can escape the endosome at an early stage with an intact RNA payload.
DOI: 10.5286/isis.e.rb2220322-1
title: Endosomal Interaction of Lipid Nanoparticles

description: There has been a shift in the pharma industry towards development of medicines containing therapeutic agents acting at sub-cellular compartments, thereby creating a demand for advanced delivery vehicles that convey their payload to the required site of action. A feature of intracellular delivery is that the vehicle is taken up by the target cells via endocytosis with the vehicle and its payload becoming engulfed in the endosome. In order for the therapeutic molecule to exert its effect, it must escape from the endosome. Neutron reflectometry coupled with contrast variation will help to unravel the interaction(s) between lipid nanoparticles (LNPs) carrying RNA and containing different ionisable lipids and the endosomal membrane (particularly the early stage endosomal membrane) to enable the design of efficient LNPs that can escape the endosome at an early stage with an intact RNA payload.
DOI: 10.3535/pl1-wf3-p75
title: Cynosurus cristatus L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2220139
title: SANS study of antimicrobial synergy from pairing of lipopeptides and antibiotics against drug-resistant bacteria

description: Cationic lipopeptides are amphiphilic; they self-assemble and easily bind to anionic bacterial membranes. When used as a binary mixture with antibiotics such as tetracycline (TC), they interact strongly to form new aggregates. Thus, binary lipopeptide-TC complexes may interact with bacterial membrane differently from their individual components. The broad aim of this work is to reveal how representative pairs of lipopeptide-antibiotic mixtures interact with model bacterial membranes by SANS. This work will offer important insight in lipopeptide design in combinational therapy.
DOI: 10.5286/isis.e.rb2220139-1
title: SANS study of antimicrobial synergy from pairing of lipopeptides and antibiotics against drug-resistant bacteria

description: Cationic lipopeptides are amphiphilic; they self-assemble and easily bind to anionic bacterial membranes. When used as a binary mixture with antibiotics such as tetracycline (TC), they interact strongly to form new aggregates. Thus, binary lipopeptide-TC complexes may interact with bacterial membrane differently from their individual components. The broad aim of this work is to reveal how representative pairs of lipopeptide-antibiotic mixtures interact with model bacterial membranes by SANS. This work will offer important insight in lipopeptide design in combinational therapy.
DOI: 10.5286/isis.e.rb2220171-1
title: Identification of a Biomimetic Membrane Forming Mechanism in Extra-Terrestrial Environments

description: Cell membranes are complex structures that are robust enough to withstand changes in temperature and pressure, yet are stable and flexible enough to cope with a vast library of cellular processes. However, the mild conditions on Earth - conditions where water is liquid and membranes can be thermally stable - are famously scarce in the vastness of space. Recent data collected by the Cassini-Huygens probe, and subsequently studied by computer modelling has shown that some nitrogen-containing molecules may be able to spontaneously form membrane-like structures in the cold liquid methane lakes on Titan, one of the moons of Saturn. By recreating this atmosphere at ISIS and probing the behaviour of these molecules using neutron scattering, we hope to show that some of the processes we take for granted on Earth may also be possible in the alien atmosphere of Titan.
DOI: 10.3535/gch-p1p-47q
title: Onosma sericea Willd.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/n8a-2z9-fhq
title: Hordeum vulgare subsp. spontaneum (K.Koch) Asch. & Graebn.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2220171
title: Identification of a Biomimetic Membrane Forming Mechanism in Extra-Terrestrial Environments

description: Cell membranes are complex structures that are robust enough to withstand changes in temperature and pressure, yet are stable and flexible enough to cope with a vast library of cellular processes. However, the mild conditions on Earth - conditions where water is liquid and membranes can be thermally stable - are famously scarce in the vastness of space. Recent data collected by the Cassini-Huygens probe, and subsequently studied by computer modelling has shown that some nitrogen-containing molecules may be able to spontaneously form membrane-like structures in the cold liquid methane lakes on Titan, one of the moons of Saturn. By recreating this atmosphere at ISIS and probing the behaviour of these molecules using neutron scattering, we hope to show that some of the processes we take for granted on Earth may also be possible in the alien atmosphere of Titan.
DOI: 10.5286/isis.e.rb2220409
title: Magnetic excitations of single molecule magnet {Dy3Cr3}

description: A new single molecule magnet {Dy3Cr3} has been discovered. It possesses a square hysteresis loop and is accordingly promising for magnetic data storage applications. It is crucial to study the intra-molecular interactions by means of inelastic neutron scattering and shed more light on the unprecedented magnetic behaviours of {Dy3Cr3}. INS is a direct and unique probe to determine the magnetic quantum levels by measuring the magnetic excitations. We propose to measure the low-lying magnetic excitations on LET and determine unambiguously the intramolecular exchange constants. The spin Hamiltonian will be established according to the INS results. With the INS results, we should be able to get more insight to the origin of the magnetic anisotropy of this single molecule magnet {Dy3Cr3}.
DOI: 10.5286/isis.e.rb2220409-1
title: Magnetic excitations of single molecule magnet {Dy3Cr3}

description: A new single molecule magnet {Dy3Cr3} has been discovered. It possesses a square hysteresis loop and is accordingly promising for magnetic data storage applications. It is crucial to study the intra-molecular interactions by means of inelastic neutron scattering and shed more light on the unprecedented magnetic behaviours of {Dy3Cr3}. INS is a direct and unique probe to determine the magnetic quantum levels by measuring the magnetic excitations. We propose to measure the low-lying magnetic excitations on LET and determine unambiguously the intramolecular exchange constants. The spin Hamiltonian will be established according to the INS results. With the INS results, we should be able to get more insight to the origin of the magnetic anisotropy of this single molecule magnet {Dy3Cr3}.
DOI: 10.3535/9h1-6z9-3b3
title: Anthoxanthum odoratum L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/j3t-nk9-jaj
title: Avenula pubescens (Huds.) Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2010905-2
title: NEUTRON TOMOGRAPHY STUDIES OF GEOPOLYMER CERAMIC USED FOR REINFORCEMENT MATERIALS IN SOLDER ALLOYS FOR A ROBUST ELECTRONIC SOLDER JOINT

description: The focus of composite solders has been in improving the mechanical behaviour for producing a robust solder joint for a highly reliable electronic device. Recently, our research group has discovered that geopolymer ceramic could be used as an alternative reinforcement material in solder alloys.The formation of porosity in geopolymer ceramics is crucial on mechanical and electrical properties of solder composites where open and closed pores in the reinforcement particles could enhance the reinforcement/matrix mechanical bonding and reduce the electrical resistivity of the solder joint. Neutrons will be used to investigate the porosity evolution and to explore the change in amorphous to crystalline phase distributions (using energy dispersive techniques). This includes looking into the moisture and porosity relations and its growth kinetics after sintering (heating) process.
DOI: 10.5286/isis.e.rb2210249-2
title: Structure of Betaine-Glycerol Deep Eutectic Solvents with Iron Ions

description: Deep euetctic solvents (DES) are an emerging group of hydrogen bonding solvents, which have garnered interest due to their greener and highly tuneable nature. Most studies have focused on halogen containing DES, and the halide ion has been identified as a significant contributor to both the solvent structure and solvation processes. But these DES can be unsuitable for applications such as catalysis due to catalyst poisoning, and here we aim to investigate the processes behind the solvation of iron nitrate in the halogen free DES betaine:glycerol (molar ratio of 1:3). We aim to compare this to the neat DES structure previously studied by us. Through in situ measurements we will also investigate the structure and processes during iron oxide nanoparticle formation, to form a comprehensive image of the system together with the in situ EXAFS measurements we have collected for this system.
DOI: 10.5286/isis.e.rb2220215-1
title: Understanding alignment in gel noodles

description: We can prepare gel noodles by extruding a solution of a dipeptide at high pH into a salt bath. The noodles formed have sufficiently mechanically integrity to be manipulated and lifted out of solution. An potential advantage of these over bulk gels is that it appears that there is a significant degree of molecular alignment within these structures, opening up applications such as conducting wires. We need to quantify this alignment. Using SAXS, we could determine alignment from dried noodles, but not from wet noodles, which we believe is due to a lack of contrast. Here, we will use SANS relying on the contrast difference between gelator and D2O.
DOI: 10.3535/q8d-yqv-g35
title: Delphinium axilliflorum DC.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/qlb-pk1-ml4
title: Bromus sterilis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5286/isis.e.rb2220087-1
title: Influence of cure conditions on barrier properties and interface of epoxy coatings

description: Epoxy resins are often used as barrier coatings to ship liquid cargoes. To eliminate failures from pinhole defects in a single coating layer, a two-layer coat is used. The curing extent of the first layer before the second layer is applied dictates the coating's solvent barrier performance. The interlayer adhesion depends on the ability of the first layer to react with the second. Consequently the interface of the partially cured layer is of great importance. We will use NR to study spin-cast epoxy resin coatings that have experienced a range of controlled curing conditions against perdeuterated solvents. These experiments will characterise the extent to which solvent can penetrate the partially cured epoxy as well as the detail of the composition profile at the interface. Crucially, NR can also measure solvent accumulation at the interface between layers in a two-layer coating.