cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5129860
title: Supplementary Material for: Leukocyte Profile in Peripheral Blood and Neutrophil-Lymphocyte Ratio in Hidradenitis Suppurativa: A Comparative Cross-Sectional Study of 462 Cases

description: <b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease. Increasing evidence suggests that HS involves dysfunctional immune responses in both the adaptive and the innate immune system. The recently proposed association of HS with metabolic syndrome may further add to the inflammatory state in HS. <b><i>Objective:</i></b> To investigate the status of inflammation and leukocyte profile in the peripheral blood of HS patients. <b><i>Materials and Methods:</i></b> Using a comparative cross-sectional study design, we investigated blood samples of high-sensitivity C-reactive protein (hs-CRP) and leukocyte profile in hospital-treated HS patients (HS-HOSP), self-reported population-based HS patients (HS-POP) and population controls. <b><i>Results:</i></b> Our study comprised 32 individuals in the HS-HOSP group, 430 in the HS-POP group, and 20,780 controls. The median hs-CRP for the HS-HOSP group was 5.1 mg/l (quartile range 2.6-8.2), 2.2 mg/l (1.0-4.3) for the HS-POP group and 1.3 mg/l (0.7-2.9) for the controls. An age-sex-adjusted analysis revealed a significantly higher hs-CRP for both HS groups compared to controls (p &lt; 0.0001). When performing age-sex-adjusted analysis, both HS groups had significantly higher odds of leukocytosis when compared to controls with an odds ratio for the HS-HOSP group of 4.38 (95% CI = 2.18-8.80; p &lt; 0.0001) and 1.95 (95% CI = 1.58-2.42; p &lt; 0.0001) for the HS-POP group. The age-sex-adjusted leukocyte differential count yielded significantly higher neutrophil (p &lt; 0.0001) and monocyte (p = 0.0014, p = 0.0004) levels in the HS groups compared with controls. <b><i>Conclusion:</i></b> The hs-CRP levels associated with HS appear to be intermediate (2.2-5.1 mg/l), implying systemic inflammation rather than infection. The peripheral blood leukocytosis in HS was dominated by neutrophils and monocytes.
DOI: 10.6084/m9.figshare.5129863
title: Supplementary Material for: Parental Smoking and Smoking Cognitions among Youth: A Systematic Review of the Literature

description: <b><i>Aims:</i></b> We summarized and discussed the empirical evidence for an association between parental smoking and smoking-related cognitions among youth and for the mediating role of smoking-related cognitions in the relation between parental and youth smoking behaviour. <b><i>Methods:</i></b> We conducted a systematic review of articles published between 1980 and February 2015 using the databases PsychInfo and PubMed. <b><i>Results:</i></b> The systematic search resulted in 41 eligible studies. Only 4 studies investigated smoking-related cognitions as putative mediators in the association between parental and youth smoking. The synthesis of evidence showed a mix of significant and non-significant associations between parental smoking and smoking-related cognitions among youth. A majority of results reported positive associations even when non-significant findings were found. However, studies that report an effect suggest that the effect may be quite modest. <b><i>Conclusion:</i></b> Empirical evidence does not confirm the commonly applied assertions of social learning theories that parental smoking increases the risk of youth smoking through the development of favourable smoking-related cognitions. Methodological and theoretical aspects that might explain the lack of consistent findings are discussed.
DOI: 10.6084/m9.figshare.5129869.v1
title: Supplementary Material for: Ranibizumab in Myopic Choroidal Neovascularization: A Subgroup Analysis by Ethnicity, Age, and Ocular Characteristics in RADIANCE

description: <b><i>Purpose:</i></b> To assess the impact of ethnicity, age, and ocular characteristics on ranibizumab efficacy in myopic choroidal neovascularization (CNV). <b><i>Methods:</i></b> In this post hoc subgroup analysis from the phase III RADIANCE study, best-corrected visual acuity (BCVA) outcomes and treatment exposure were analyzed in 105 patients treated with ranibizumab 0.5 mg. Baseline categories included ethnicity, age, baseline BCVA, lesion area, CNV lesion area, refraction sphere, axial length, subretinal fluid, and location of CNV. <b><i>Results:</i></b> At month 12, the mean change in BCVA was numerically higher in East-Asians than in Caucasians (17.0 vs. 14.1 letters). The median number of injections varied with ethnicity (East-Asians vs. Caucasians: 2 vs. 3), baseline BCVA (highest vs. lowest: 1 vs. 4), CNV lesion area and lesion area (largest vs. smallest: 5 vs. 1 and 5 vs. 2). <b><i>Conclusions:</i></b> East-Asians showed numerically higher BCVA gains than Caucasians. The number of injections varied across subgroups, emphasizing the need for individualized treatment.
DOI: 10.6084/m9.figshare.5129857
title: Supplementary Material for: Use of Complementary and Alternative Medicine in Cancer Patients: A Prospective Questionnaire-Based Study in an Oncological Outpatient Clinic

description: <b><i>Background:</i></b> A questionnaire-based prospective study was conducted to evaluate the current use of complementary and alternative medicine (CAM) in a hemato-oncological outpatient clinic. <b><i>Methods:</i></b> A multiple-choice questionnaire was designed to assess the use of CAM in a hemato-oncological outpatient clinic. It consisted of questions on sociodemographic and general patient data, and of different kind of questions concerning the use of CAM, including disclosure rates to oncologists and general physicians. The data was analyzed with SAS and a p-value &lt; 0.05 was considered as statistically significant. <b><i>Results:</i></b> 46 out of 251 patients (18%) indicated to use CAM. 62 out of all patients (25%) discussed the topic with their general physician or oncologist. Praying or nutritional supplements were the most often used type of CAM. 95 of all participating patients found that the use of CAM could be helpful. <b><i>Conclusions:</i></b> The findings of our monocentric study in an outpatient setting do not support the relatively high percentage of CAM users described in the current literature. Nevertheless, CAM needs to be defined more clearly, in order to increase the patients' awareness of CAM.
DOI: 10.6084/m9.figshare.5129863.v1
title: Supplementary Material for: Parental Smoking and Smoking Cognitions among Youth: A Systematic Review of the Literature

description: <b><i>Aims:</i></b> We summarized and discussed the empirical evidence for an association between parental smoking and smoking-related cognitions among youth and for the mediating role of smoking-related cognitions in the relation between parental and youth smoking behaviour. <b><i>Methods:</i></b> We conducted a systematic review of articles published between 1980 and February 2015 using the databases PsychInfo and PubMed. <b><i>Results:</i></b> The systematic search resulted in 41 eligible studies. Only 4 studies investigated smoking-related cognitions as putative mediators in the association between parental and youth smoking. The synthesis of evidence showed a mix of significant and non-significant associations between parental smoking and smoking-related cognitions among youth. A majority of results reported positive associations even when non-significant findings were found. However, studies that report an effect suggest that the effect may be quite modest. <b><i>Conclusion:</i></b> Empirical evidence does not confirm the commonly applied assertions of social learning theories that parental smoking increases the risk of youth smoking through the development of favourable smoking-related cognitions. Methodological and theoretical aspects that might explain the lack of consistent findings are discussed.
DOI: 10.6084/m9.figshare.5129854
title: Supplementary Material for: Enumeration and Molecular Characterisation of Circulating Tumour Cells in Endometrial Cancer

description: <b><i>Background:</i></b> This is a feasibility study to determine whether circulating tumour cells (CTCs) are detectable and suitable for molecular profiling in advanced endometrial cancer (aEC). <b><i>Method:</i></b> Between October 2012 and February 2014, 30 patients with aEC had baseline and up to 3 follow-up samples. CTCs and stathmin expression were evaluated using the CellSearch platform. Epithelial cell adhesion molecule (EpCAM) and stathmin immunohistochemistry were performed on FFPE tumour tissue. <b><i>Results:</i></b> Eighteen from 30 (60%) patients had detectable CTCs during study [1 CTC (n = 7), 2 (n = 4), 3 (n = 1), 4 (n = 2), 7 (n = 1), 8 (n = 1), 22 (n = 1), 172 (n = 1) in 7.5 ml blood]. Ten from 18 patients had between 50 and 100% of detectable CTCs that were stathmin positive. More CTC-positive than CTC-negative patients had non-endometrioid versus endometrioid histology, tumour size ≥5 versus &lt;5 cm, higher-stage disease and worse survival [hazard ratio 3.3, p &gt; 0.05, 95% confidence interval 0.7-16.2]. Twenty-one tumour blocks were tested for EpCAM and stathmin immunohistochemistry (IHC). Stathmin tumour immunostaining scores (TIS) on IHC were higher in CTC-positive patients. <b><i>Conclusion:</i></b> CTC enumeration and molecular profiling with stathmin on the CellSearch platform is feasible in aEC. Stathmin TIS on IHC, a known prognostic marker in EC, was associated with CTC positivity.
DOI: 10.6084/m9.figshare.5129860.v1
title: Supplementary Material for: Leukocyte Profile in Peripheral Blood and Neutrophil-Lymphocyte Ratio in Hidradenitis Suppurativa: A Comparative Cross-Sectional Study of 462 Cases

description: <b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease. Increasing evidence suggests that HS involves dysfunctional immune responses in both the adaptive and the innate immune system. The recently proposed association of HS with metabolic syndrome may further add to the inflammatory state in HS. <b><i>Objective:</i></b> To investigate the status of inflammation and leukocyte profile in the peripheral blood of HS patients. <b><i>Materials and Methods:</i></b> Using a comparative cross-sectional study design, we investigated blood samples of high-sensitivity C-reactive protein (hs-CRP) and leukocyte profile in hospital-treated HS patients (HS-HOSP), self-reported population-based HS patients (HS-POP) and population controls. <b><i>Results:</i></b> Our study comprised 32 individuals in the HS-HOSP group, 430 in the HS-POP group, and 20,780 controls. The median hs-CRP for the HS-HOSP group was 5.1 mg/l (quartile range 2.6-8.2), 2.2 mg/l (1.0-4.3) for the HS-POP group and 1.3 mg/l (0.7-2.9) for the controls. An age-sex-adjusted analysis revealed a significantly higher hs-CRP for both HS groups compared to controls (p &lt; 0.0001). When performing age-sex-adjusted analysis, both HS groups had significantly higher odds of leukocytosis when compared to controls with an odds ratio for the HS-HOSP group of 4.38 (95% CI = 2.18-8.80; p &lt; 0.0001) and 1.95 (95% CI = 1.58-2.42; p &lt; 0.0001) for the HS-POP group. The age-sex-adjusted leukocyte differential count yielded significantly higher neutrophil (p &lt; 0.0001) and monocyte (p = 0.0014, p = 0.0004) levels in the HS groups compared with controls. <b><i>Conclusion:</i></b> The hs-CRP levels associated with HS appear to be intermediate (2.2-5.1 mg/l), implying systemic inflammation rather than infection. The peripheral blood leukocytosis in HS was dominated by neutrophils and monocytes.
DOI: 10.6084/m9.figshare.5129866.v1
title: Supplementary Material for: Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation

description: <b><i>Background:</i></b> A recent genome-wide association study (GWAS) by our group identified 13 loci associated with the plasma triglyceride (TG) response to omega-3 (n-3) fatty acid (FA) supplementation. This study aimed to test whether single-nucleotide polymorphisms (SNPs) within the <i>IQCJ, NXPH1, PHF17</i> and <i>MYB</i> genes are associated with the plasma TG response to an n-3 FA supplementation. <b><i>Methods:</i></b> A total of 208 subjects followed a 6-week n-3 FA supplementation of 5 g/day of fish oil (1.9-2.2 g of eicosapentaenoic acid and 1.1 g of docosahexaenoic acid). Measurements of plasma lipids were made before and after the supplementation. Sixty-seven tagged SNPs were selected to increase the density of markers near GWAS hits. <b><i>Results:</i></b> In a repeated model, independent effects of the genotype and the gene-supplementation interaction were associated with plasma TG. Genotype effects were observed with two SNPs of <i>NXPH1</i>, and gene-diet interactions were observed with ten SNPs of <i>IQCJ</i>, four SNPs of <i>NXPH1</i> and three SNPs of <i>MYB</i>. Positive and negative responders showed different genotype frequencies with nine SNPs of <i>IQCJ</i>, two SNPs of <i>NXPH1</i> and two SNPs of <i>MYB</i>. <b><i>Conclusion:</i></b> Fine mapping in GWAS-associated loci allowed the identification of SNPs partly explaining the large interindividual variability observed in plasma TG levels in response to an n-3 FA supplementation.
DOI: 10.6084/m9.figshare.5129842
title: Supplementary Material for: Preparation and Adsorption Properties of Novel Porous Microspheres with Different Concentrations of Bilirubin

description: <b><i>Background:</i></b> Plasma perfusion was widely used to clear toxic substances of plasma. Particle size and uniformity of adsorbent microspheres also affect the absorption rate. <b><i>Methods:</i></b> Conventional suspension polymerization was improved using a pre-dispersion homogenizer to obtain novel adsorbent microspheres, named ERM-0100. Microsphere-related characteristics and attributes were analysed. <b><i>Result:</i></b> The ERM-0100 microspheres efficiently adsorbed different bilirubin concentrations, with a maximum rate of 59.72 ± 1.08%. At high bilirubin concentrations, ERM-0100 exhibited similar adsorption rate with BRS350 and BS330 (p = 0.303, p = 1.000, relatively), and higher than HB-H-6 (p = 0.000). At different concentration, ERM-0100 showed good adsorption performance. The ERM-0100 had no significant adsorption for electrolyte; for TP and ALB, the loss rates of ERM-0100 were 15.65 ± 0.36 and 23.23 ± 1.11%, respectively. In addition, ERM-0100 showed good blood compatibility. <b><i>Conclusion:</i></b> The ERM-0100 is a potential biomedical material for plasma perfusion for good effect, less costs and more safety. The microspheres may be coated to reduce its protein adsorption.
DOI: 10.6084/m9.figshare.5129845
title: Supplementary Material for: Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions

description: <b><i>Background:</i></b> Psoriasis is a chronic inflammatory skin disease characterized by plaques with inflammation, infiltration, hyper-/parakeratosis and desquamation. Microscopic findings in previous studies have revealed some degree of atrophy of the sebaceous glands in patients with psoriasis vulgaris and psoriatic alopecia. <b><i>Objective:</i></b> The aim of this study was to investigate possible changes of the sebaceous glands in patients with psoriatic plaques and especially psoriatic alopecia. <b><i>Methods:</i></b> Histological and stereological analyses were performed in skin specimens from involved and healthy-looking skin of 14 patients with psoriasis. Stereology detects and quantifies 3-dimensional structures ex vivo. Furthermore, the differentiation process of sebocytes of another 14 psoriatic patients was examined by immunohistochemistry of involved and uninvolved skin specimens. <b><i>Results:</i></b> A significant reduction of the number of sebaceous glands as well as of the volume of individual sebaceous glands was assessed in the lesional compared to the nonlesional psoriatic skin. Moreover, it was likely that sebocytes in psoriatic lesions may not differentiate properly. <b><i>Conclusion:</i></b> These findings indicate that the sebaceous gland may be a player and not an innocent bystander in the development of psoriatic lesions and especially of psoriatic alopecia.
DOI: 10.6084/m9.figshare.5129848
title: Supplementary Material for: Food Web Structure Shapes the Morphology of Teleost Fish Brains

description: Previous work showed that teleost fish brain size correlates with the flexible exploitation of habitats and predation abilities in an aquatic food web. Since it is unclear how regional brain changes contribute to these relationships, we quantitatively examined the effects of common food web attributes on the size of five brain regions in teleost fish at both within-species (plasticity or natural variation) and between-species (evolution) scales. Our results indicate that brain morphology is influenced by habitat use and trophic position, but not by the degree of littoral-pelagic habitat coupling, despite the fact that the total brain size was previously shown to increase with habitat coupling in Lake Huron. Intriguingly, the results revealed two potential evolutionary trade-offs: (i) relative olfactory bulb size increased, while relative optic tectum size decreased, across a trophic position gradient, and (ii) the telencephalon was relatively larger in fish using more littoral-based carbon, while the cerebellum was relatively larger in fish using more pelagic-based carbon. Additionally, evidence for a within-species effect on the telencephalon was found, where it increased in size with trophic position. Collectively, these results suggest that food web structure has fundamentally contributed to the shaping of teleost brain morphology.
DOI: 10.6084/m9.figshare.5129851
title: Supplementary Material for: Long-Term Survival Following Traumatic Brain Injury: A Population-Based Parametric Survival Analysis

description: <b><i>Background:</i></b> Long-term mortality may be increased following traumatic brain injury (TBI); however, the degree to which survival could be reduced is unknown. We aimed at modelling life expectancy following post-acute TBI to provide predictions of longevity and quantify differences in survivorship with the general population. <b><i>Methods:</i></b> A population-based retrospective cohort study using data from the Rochester Epidemiology Project (REP) was performed. A random sample of patients from Olmsted County, Minnesota with a confirmed TBI between 1987 and 2000 was identified and vital status determined in 2013. Parametric survival modelling was then used to develop a model to predict life expectancy following TBI conditional on age at injury. Survivorship following TBI was also compared with the general population and age- and gender-matched non-head injured REP controls. <b><i>Results:</i></b> Seven hundred and sixty nine patients were included in complete case analyses. The median follow-up time was 16.1 years (interquartile range 9.0-20.4) with 120 deaths occurring in the cohort during the study period. Survival after acute TBI was well represented by a Gompertz distribution. Victims of TBI surviving for at least 6 months post-injury demonstrated a much higher ongoing mortality rate compared to the US general population and non-TBI controls (hazard ratio 1.47, 95% CI 1.15-1.87). US general population cohort life table data was used to update the Gompertz model's shape and scale parameters to account for cohort effects and allow prediction of life expectancy in contemporary TBI. <b><i>Conclusions:</i></b> Survivors of TBI have decreased life expectancy compared to the general population. This may be secondary to the head injury itself or result from patient characteristics associated with both the propensity for TBI and increased early mortality. Post-TBI life expectancy estimates may be useful to guide prognosis, in public health planning, for actuarial applications and in the extrapolation of outcomes for TBI economic models.
DOI: 10.6084/m9.figshare.5129857.v1
title: Supplementary Material for: Use of Complementary and Alternative Medicine in Cancer Patients: A Prospective Questionnaire-Based Study in an Oncological Outpatient Clinic

description: <b><i>Background:</i></b> A questionnaire-based prospective study was conducted to evaluate the current use of complementary and alternative medicine (CAM) in a hemato-oncological outpatient clinic. <b><i>Methods:</i></b> A multiple-choice questionnaire was designed to assess the use of CAM in a hemato-oncological outpatient clinic. It consisted of questions on sociodemographic and general patient data, and of different kind of questions concerning the use of CAM, including disclosure rates to oncologists and general physicians. The data was analyzed with SAS and a p-value &lt; 0.05 was considered as statistically significant. <b><i>Results:</i></b> 46 out of 251 patients (18%) indicated to use CAM. 62 out of all patients (25%) discussed the topic with their general physician or oncologist. Praying or nutritional supplements were the most often used type of CAM. 95 of all participating patients found that the use of CAM could be helpful. <b><i>Conclusions:</i></b> The findings of our monocentric study in an outpatient setting do not support the relatively high percentage of CAM users described in the current literature. Nevertheless, CAM needs to be defined more clearly, in order to increase the patients' awareness of CAM.
DOI: 10.6084/m9.figshare.5129839
title: Supplementary Material for: Pulmonary Disease Caused by Non-Tuberculous Mycobacteria

description: Non-tuberculous mycobacteria (NTM) include more than 160 ubiquitous, environmental, acid-fast-staining bacterial species, some of which may cause disease in humans. Chronic pulmonary infection is the most common clinical manifestation. Although patients suffering from chronic lung diseases are particularly susceptible to NTM pulmonary disease, many affected patients have no apparent risk factors. Host and pathogen factors leading to NTM pulmonary disease are not well understood and preventive therapies are lacking. NTM isolation and pulmonary disease are reported to rise in frequency in Europe as well as in other parts of the world. Differentiation between contamination, infection, and disease remains challenging. Treatment of NTM pulmonary disease is arduous, lengthy, and costly. Correlations between results of in vitro antibiotic susceptibility testing and clinical treatment outcomes are only evident for the <i>Mycobacterium avium</i> complex, <i>M. kansasii</i>, and some rapidly growing mycobacteria. We describe the epidemiology of NTM pulmonary disease as well as emerging NTM pathogens and their geographical distribution in non-cystic fibrosis patients in Europe. We also review recent innovations for the diagnosis of NTM pulmonary disease, summarize treatment recommendations, and identify future research priorities to improve the management of patients affected by NTM pulmonary disease.