cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14473/csda/icjgda/morctz
title: TI_CHPS104, 105, 204, 205, 304, 305.pdf

description: Technical information
DOI: 10.6084/m9.figshare.21370851
title: Functional study and epigenetic targets analyses of <i>SIRT1</i> in intramuscular preadipocytes via ChIP-seq and mRNA-seq

description: The <i>SIRT1</i> epigenetic regulator is involved in hepatic lipid homoeostasis. However, the role of <i>SIRT1</i> in regulating intramuscular fat deposition as well as the pathways and potential epigenetic targets involved remain unknown. Herein, we investigate <i>SIRT1</i> function, its genome-wide epigenetic target profile, and transcriptomic changes under <i>SIRT1</i> overexpression during yak intramuscular preadipocytes differentiation. To this end, we analysed the relationship between <i>SIRT1</i> and intramuscular fat content as well as lipid metabolism-related genes in <i>longissimus dorsi</i> tissue. We found that <i>SIRT1</i> expression negatively correlates with intramuscular fat content as well as with the expression of genes related to lipid synthesis, while positively correlating with that of fatty acid oxidation-involved genes. <i>SIRT1</i> overexpression in intramuscular preadipocytes significantly reduced adipose differentiation marker expression, intracellular triacylglycerol content, and lipid deposition. Chromatin immunoprecipitation coupled with high-throughput sequencing of H3K4ac (a known direct target of <i>SIRT1</i>) and high-throughput mRNA sequencing results revealed that <i>SIRT1</i> may regulate intramuscular fat deposition via three potential new transcription factors (NRF1, NKX3.1, and EGR1) and four genes (<i>MAPK1, RXRA, AGPAT1</i>, and <i>HADH</i>) implicated in protein processing within the endoplasmic reticulum pathway and the MAPK signalling pathway in yaks. Our study provides novel insights into the role of <i>SIRT1</i> in regulating yak intramuscular fat deposition and may help clarify the mechanistic determinants of yak meat characteristics.
DOI: 10.6084/m9.figshare.21370851.v2
title: Functional study and epigenetic targets analyses of <i>SIRT1</i> in intramuscular preadipocytes via ChIP-seq and mRNA-seq

description: The <i>SIRT1</i> epigenetic regulator is involved in hepatic lipid homoeostasis. However, the role of <i>SIRT1</i> in regulating intramuscular fat deposition as well as the pathways and potential epigenetic targets involved remain unknown. Herein, we investigate <i>SIRT1</i> function, its genome-wide epigenetic target profile, and transcriptomic changes under <i>SIRT1</i> overexpression during yak intramuscular preadipocytes differentiation. To this end, we analysed the relationship between <i>SIRT1</i> and intramuscular fat content as well as lipid metabolism-related genes in <i>longissimus dorsi</i> tissue. We found that <i>SIRT1</i> expression negatively correlates with intramuscular fat content as well as with the expression of genes related to lipid synthesis, while positively correlating with that of fatty acid oxidation-involved genes. <i>SIRT1</i> overexpression in intramuscular preadipocytes significantly reduced adipose differentiation marker expression, intracellular triacylglycerol content, and lipid deposition. Chromatin immunoprecipitation coupled with high-throughput sequencing of H3K4ac (a known direct target of <i>SIRT1</i>) and high-throughput mRNA sequencing results revealed that <i>SIRT1</i> may regulate intramuscular fat deposition via three potential new transcription factors (NRF1, NKX3.1, and EGR1) and four genes (<i>MAPK1, RXRA, AGPAT1</i>, and <i>HADH</i>) implicated in protein processing within the endoplasmic reticulum pathway and the MAPK signalling pathway in yaks. Our study provides novel insights into the role of <i>SIRT1</i> in regulating yak intramuscular fat deposition and may help clarify the mechanistic determinants of yak meat characteristics.
DOI: 10.6084/m9.figshare.21370851.v1
title: Functional study and epigenetic targets analyses of <i>SIRT1</i> in intramuscular preadipocytes via ChIP-seq and mRNA-seq

description: The <i>SIRT1</i> epigenetic regulator is involved in hepatic lipid homoeostasis. However, the role of <i>SIRT1</i> in regulating intramuscular fat deposition as well as the pathways and potential epigenetic targets involved remain unknown. Herein, we investigate <i>SIRT1</i> function, its genome-wide epigenetic target profile, and transcriptomic changes under <i>SIRT1</i> overexpression during yak intramuscular preadipocytes differentiation. To this end, we analysed the relationship between <i>SIRT1</i> and intramuscular fat content as well as lipid metabolism-related genes in <i>longissimus dorsi</i> tissue. We found that <i>SIRT1</i> expression negatively correlates with intramuscular fat content as well as with the expression of genes related to lipid synthesis, while positively correlating with that of fatty acid oxidation-involved genes. <i>SIRT1</i> overexpression in intramuscular preadipocytes significantly reduced adipose differentiation marker expression, intracellular triacylglycerol content, and lipid deposition. Chromatin immunoprecipitation coupled with high-throughput sequencing of H3K4ac (a known direct target of <i>SIRT1</i>) and high-throughput mRNA sequencing results revealed that <i>SIRT1</i> may regulate intramuscular fat deposition via three potential new transcription factors (NRF1, NKX3.1, and EGR1) and four genes (<i>MAPK1, RXRA, AGPAT1</i>, and <i>HADH</i>) implicated in protein processing within the endoplasmic reticulum pathway and the MAPK signalling pathway in yaks. Our study provides novel insights into the role of <i>SIRT1</i> in regulating yak intramuscular fat deposition and may help clarify the mechanistic determinants of yak meat characteristics.
DOI: 10.6084/m9.figshare.15079451
title: Exosome-mediated transfer of circHIPK3 promotes trastuzumab chemoresistance in breast cancer

description: Breast cancer (BC) remains a public health dilemma in the world and it is one of the leading causes of death among women. Trastuzumab is a kind of commonly-used drugs in the treatment of BC, which especially can provide substantial benefits for HER2-positive BC. However, its long-time usage results in the emergence of resistance, which cuts down its efficacy in BC and leads to a poorer overall survival rate. Hence, the attempt of this study was to investigate how the drug resistance was enhanced. It has been identified that circHIPK3 could act as an oncogene in BC and promoted cell development through and a series of function assays. However, the underlying regulatory mechanism of circHIPK3 is not well established in trastuzumab resistance to date. Furthermore, we found the functional role of exosomes in trastuzumab chemoresistance and discovered that exosomes derived from trastuzumab-resistant cells could enhance the drug resistance of trastuzumab-sensitive cells. In last decades, competing endogenous RNA (ceRNA) has been a hot topic to investigate potential mechanism in cells. We subsequently performed mechanism experiments and rescue assays to verify circHIPK3 acted as a ceRNA in BC cells. In conclusion, we uncovered the regulatory mechanism by which exosome-transmitted circHIPK3 could promote trastuzumab chemoresistance of drug-sensitive BC cells.
DOI: 10.6084/m9.figshare.15079451.v1
title: Exosome-mediated transfer of circHIPK3 promotes trastuzumab chemoresistance in breast cancer

description: Breast cancer (BC) remains a public health dilemma in the world and it is one of the leading causes of death among women. Trastuzumab is a kind of commonly-used drugs in the treatment of BC, which especially can provide substantial benefits for HER2-positive BC. However, its long-time usage results in the emergence of resistance, which cuts down its efficacy in BC and leads to a poorer overall survival rate. Hence, the attempt of this study was to investigate how the drug resistance was enhanced. It has been identified that circHIPK3 could act as an oncogene in BC and promoted cell development through and a series of function assays. However, the underlying regulatory mechanism of circHIPK3 is not well established in trastuzumab resistance to date. Furthermore, we found the functional role of exosomes in trastuzumab chemoresistance and discovered that exosomes derived from trastuzumab-resistant cells could enhance the drug resistance of trastuzumab-sensitive cells. In last decades, competing endogenous RNA (ceRNA) has been a hot topic to investigate potential mechanism in cells. We subsequently performed mechanism experiments and rescue assays to verify circHIPK3 acted as a ceRNA in BC cells. In conclusion, we uncovered the regulatory mechanism by which exosome-transmitted circHIPK3 could promote trastuzumab chemoresistance of drug-sensitive BC cells.
DOI: 10.6084/m9.figshare.20846620
title: Comparative effect of ciprofloxacin and moxifloxacin on the modulation of bile acid profiles and gut microbiota in rats

description: Abstract Fluoroquinolones are an important class of antimicrobial agents to manage infectious diseases. However, knowledge about how host bile acids are modified by fluoroquinolones is limited. We investigated and compared the impact of fluoroquinolones on circulating bile acid profiles and gut microbiota from in vivo studies. We administered ciprofloxacin (100 mg/kg/day) or moxifloxacin (40 mg/kg/day) orally to male Wistar rats for seven days. Fifteen bile acids (BAs) from the serum and large intestine were quantified by HPLC-MS/MS. The diversity of gut microbiota after ciprofloxacin and moxifloxacin treatment was analyzed using high-throughput, next-generation sequencing technology. The two fluoroquinolone-treated groups had different BA profiles. Ciprofloxacin significantly reduced the hydrophobicity index of the BA pool, reduced secondary BAs, and increased taurine-conjugated primary BAs in both the serum and large intestine as compared with moxifloxacin. Besides, ciprofloxacin treatment altered intestinal microbiota with a remarkable increase in Firmicutes to Bacteroidetes ratio, while moxifloxacin exerted no effect. What we found suggests that different fluoroquinolones have a distinct effect on the host BAs metabolism and intestinal bacteria, and therefore provide guidance on the selection of fluoroquinolones to treat infectious diseases.
DOI: 10.6084/m9.figshare.20846620.v1
title: Comparative effect of ciprofloxacin and moxifloxacin on the modulation of bile acid profiles and gut microbiota in rats

description: Abstract Fluoroquinolones are an important class of antimicrobial agents to manage infectious diseases. However, knowledge about how host bile acids are modified by fluoroquinolones is limited. We investigated and compared the impact of fluoroquinolones on circulating bile acid profiles and gut microbiota from in vivo studies. We administered ciprofloxacin (100 mg/kg/day) or moxifloxacin (40 mg/kg/day) orally to male Wistar rats for seven days. Fifteen bile acids (BAs) from the serum and large intestine were quantified by HPLC-MS/MS. The diversity of gut microbiota after ciprofloxacin and moxifloxacin treatment was analyzed using high-throughput, next-generation sequencing technology. The two fluoroquinolone-treated groups had different BA profiles. Ciprofloxacin significantly reduced the hydrophobicity index of the BA pool, reduced secondary BAs, and increased taurine-conjugated primary BAs in both the serum and large intestine as compared with moxifloxacin. Besides, ciprofloxacin treatment altered intestinal microbiota with a remarkable increase in Firmicutes to Bacteroidetes ratio, while moxifloxacin exerted no effect. What we found suggests that different fluoroquinolones have a distinct effect on the host BAs metabolism and intestinal bacteria, and therefore provide guidance on the selection of fluoroquinolones to treat infectious diseases.
DOI: 10.14473/csda/wwumy2/buknfi
title: kf_data_bez_diakritiky_w3_chps_cz_v1.0_ENG.tab

description: Data
DOI: 10.14473/csda/wwumy2/encyhd
title: TI_CHPS104, 105, 204, 205, 304, 305.pdf

description: Technical information
DOI: 10.14473/csda/vtt61j/ozvd5i
title: tazatele_data_bez_diakritiky_w3_chps_v1.0_ENG_FIN.tab

description: Data
DOI: 10.6084/m9.figshare.21371070
title: Contrast the distribution, transformation, and degradation of dissolved and particulate organic matter in the South Yellow Sea, the East China Sea, and its adjacent Kuroshio Current

description: The detailed information of sampling stations, the carbon, nitrogen, and amino acids levels in DOM and POM, as well as other parameters including temperature, salinity, nutrients, chlorophyll-<em>a</em>, and biological parameters (heterotrophic bacteria, Synechococcus, and picoeukaryotes) are dispalyed in this dataset.
DOI: 10.6084/m9.figshare.15079636
title: Additional file 3 of Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon

description: Additional file 3.
DOI: 10.6084/m9.figshare.15079636.v1
title: Additional file 3 of Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon

description: Additional file 3.
DOI: 10.6084/m9.figshare.15079639
title: Additional file 4 of Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon

description: Additional file 4.
DOI: 10.6084/m9.figshare.15079639.v1
title: Additional file 4 of Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon

description: Additional file 4.
DOI: 10.6084/m9.figshare.15079630
title: Additional file 1 of Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon

description: Additional file 1.
DOI: 10.15468/dl.c9wuj7
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is USA.39_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Phragmites australis (Cav.) Trin., Phragmites australis subsp. salsa (Podp.) Soó, Phragmites australis var. berlanderi (E.Fourn.) C.F.Reed, 1987, Phragmites australis var. flavescens (Custer) Tzvelev)"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001984-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.0rum8g
title: Occurrence Download

description: A dataset containing 374 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tillandsia ionantha Planch."
 ]
}

 The dataset includes 374 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cqpsrw
title: Occurrence Download

description: A dataset containing 476 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is USA.39_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Phalaris arundinacea L."
 ]
}

 The dataset includes 476 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001982-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ktz3p5
title: Occurrence Download

description: A dataset containing 27643 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Mexico",
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((-99.30711 19.19791,-98.97267 19.19791,-98.97267 19.49915,-99.30711 19.49915,-99.30711 19.19791))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "InstitutionCode is inaturalist",
 "OccurrenceStatus is Present",
 "PublishingOrg is 28eb1a3f-1c15-4a95-931a-4af90ecb574d",
 "Year 2018-2019"
 ]
}

 The dataset includes 27643 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046933-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.331f5k
title: Occurrence Download

description: A dataset containing 533 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Euderma maculatum (J.A.Allen, 1891)"
 ]
}

 The dataset includes 533 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-150811131857512/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.naqem3
title: Occurrence Download

description: A dataset containing 2634 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Human Observation"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Ursus maritimus Phipps, 1774"
 ]
}

 The dataset includes 2634 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046916-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zbgcep
title: Occurrence Download

description: A dataset containing 411 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mutisia clematis L.fil."
 ]
}

 The dataset includes 411 records from 57 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001987-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.atumc4
title: Occurrence Download

description: A dataset containing 259 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brachygastra mellifica (Say, 1837)"
 ]
}

 The dataset includes 259 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-150831095807960/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.l1qsxu
title: Occurrence Download

description: A dataset containing 109270 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is ICN - Universidad Nacional de Colombia"
 ]
}

 The dataset includes 109270 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014820-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ss755b
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Stelis jubata Luer & R.Vásquez"
 ]
}

 The dataset includes 3 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0192566-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.weuttt
title: Occurrence Download

description: A dataset containing 970 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Allobates femoralis (Boulenger, 1884)"
 ]
}

 The dataset includes 970 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-150922153815467/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6sac6p
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rondeletia steirophylla Urb."
 ]
}

 The dataset includes 12 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0192567-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mhe477
title: Occurrence Download

description: A dataset containing 7908482 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry MULTIPOLYGON(((-123.46043 49.62257,-123.58803 49.53773,-123.68679 49.44272,-123.76245 49.333,-123.80645 49.22081,-123.82113 49.09916,-123.80142 48.98562,-123.75508 48.8721,-123.6792 48.76732,-123.57489 48.67007,-123.44545 48.58684,-123.29521 48.51942,-123.13883 48.47284,-122.97465 48.44232,-122.79163 48.43221,-122.62136 48.44226,-122.45136 48.47093,-122.28116 48.52176,-122.13928 48.58988,-122.01202 48.669,-121.90949 48.76545,-121.83247 48.87106,-121.78496 48.9825,-121.76663 49.10568,-121.77973 49.21827,-121.82494 49.33504,-121.89763 49.43983,-121.99598 49.53429,-122.12662 49.62125,-122.27163 49.68818,-122.44004 49.73977,-122.61309 49.77046,-122.79415 49.78064,-122.97526 49.7702,-123.14511 49.74209,-123.31349 49.68867,-123.46043 49.62257)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Animalia"
 ]
}

 The dataset includes 7908482 records from 369 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046920-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.clajrt
title: Occurrence Download

description: A dataset containing 2430 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Inventario Español de Especies Terrestres (MAGRAMA)",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 2430 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-171124123535762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d2pjet
title: Occurrence Download

description: A dataset containing 159 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Nudechinus verruculatus (Lütken, 1864)"
 ]
}

 The dataset includes 159 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0054783-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6nkcwu
title: Occurrence Download

description: A dataset containing 3790 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Latrodectus mactans (Fabricius, 1775)"
 ]
}

 The dataset includes 3790 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046928-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pnmwby
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2015",
 "Month is greater than or equal to August",
 "Country is United Arab Emirates",
 "TaxonKey is Passeriformes"
 ]
}

 The dataset includes 14 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.