cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1434692.v2
title: Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

description: Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN <i>in vivo</i> and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN for 21 d exhibited the impaired glucose tolerance and insulin sensitivity, remarkable ER stress as well as attenuated insulin signaling in liver and adipose tissue but not in skeletal muscle. Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN. Consistent with these findings <i>in vivo</i>, we also observed that PGRN treatment induced ER stress, impaired insulin signaling in cultured hepatocytes and adipocytes, with such effects being partially nullified by blockade of PERK. Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2α axis of the ER stress response in action of PGRN. Collectively, our findings supported the notion that PGRN is a key regulator of insulin resistance and that PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2α dependent pathway.
DOI: 10.6084/m9.figshare.1434692.v3
title: Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

description: Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN <i>in vivo</i> and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN for 21 d exhibited the impaired glucose tolerance and insulin sensitivity, remarkable ER stress as well as attenuated insulin signaling in liver and adipose tissue but not in skeletal muscle. Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN. Consistent with these findings <i>in vivo</i>, we also observed that PGRN treatment induced ER stress, impaired insulin signaling in cultured hepatocytes and adipocytes, with such effects being partially nullified by blockade of PERK. Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2α axis of the ER stress response in action of PGRN. Collectively, our findings supported the notion that PGRN is a key regulator of insulin resistance and that PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2α dependent pathway.
DOI: 10.6084/m9.figshare.1434687
title: MongoDB metadata for dataset "Trend of traffic incidents in Europe and North America on the 3rd of July 2015"

description: MongoDB metadata for dataset "Trend of traffic incidents in Europe and North America on the 3rd of July 2015"(see first link)
DOI: 10.6084/m9.figshare.1434686
title: Trend of traffic incidents in Europe and North America on the 3rd of July 2015

description: The data was collected using the Bing Traffic API(see 1st link). It contains contains traffic incidents in Europe and North America on the 3rd of July 2015. One record contains data about one traffic incident at a specific timestamp. The data is in BSON format and you can import it to MongoDB using the mongorestore(see 2nd link) command. When you use the mongorestore command you should include the MongoDB metadata file(see 3rd link) that a geospatial index is created on the location of the records. This is an example of one record: { "_id" : ObjectId("556ee2cbed5d282e4de2ce7f"), "timestamp" : ISODate("2015-06-03T11:19:37.819Z"), "incidentId" : NumberLong("2634956835069326936"), "description" : "Closed between Monks Eleigh and Stowmarket - Closed.", "severity" : 4, "type" : 5, "verified" : true, "start" : ISODate("2015-05-25T23:00:00Z"), "end" : ISODate("2015-07-20T22:59:59Z"), "loc" : [ 0.90825, 52.10793 ] } Here the explanation of the fields: _id: unique id of the record (given by Mongodb) timestamp: date when the record requested from the Bing Traffic API incidentID: unique id for the incident (given by the Bing Traffic API) description: a textual description of the incidents severity: the severity of the incident(1 → Low Impact, 2 → Minor, 3 → Moderate, 4 → Serious) type: the type of the incident(1 → Accident, 2 → Congestion, 3 → Disabled Vehicle, 4 → Mass Transit, 5 → Miscellaneous, 6 → Other News, 7 → Planned Event, 8 → Road Hazard, 9 → Construction, 10 → Alert, 11 → Weather) verified: if the incident is confirmed by an official source start: the date when the incident occurred end: the date when the incident will end loc: the location of the incident (latitude and longitude)
DOI: 10.6084/m9.figshare.1434686.v1
title: Trend of traffic incidents in Europe and North America on the 3rd of July 2015

description: The data was collected using the Bing Traffic API(see 1st link). It contains contains traffic incidents in Europe and North America on the 3rd of July 2015. One record contains data about one traffic incident at a specific timestamp. The data is in BSON format and you can import it to MongoDB using the mongorestore(see 2nd link) command. When you use the mongorestore command you should include the MongoDB metadata file(see 3rd link) that a geospatial index is created on the location of the records. This is an example of one record: { "_id" : ObjectId("556ee2cbed5d282e4de2ce7f"), "timestamp" : ISODate("2015-06-03T11:19:37.819Z"), "incidentId" : NumberLong("2634956835069326936"), "description" : "Closed between Monks Eleigh and Stowmarket - Closed.", "severity" : 4, "type" : 5, "verified" : true, "start" : ISODate("2015-05-25T23:00:00Z"), "end" : ISODate("2015-07-20T22:59:59Z"), "loc" : [ 0.90825, 52.10793 ] } Here the explanation of the fields: _id: unique id of the record (given by Mongodb) timestamp: date when the record requested from the Bing Traffic API incidentID: unique id for the incident (given by the Bing Traffic API) description: a textual description of the incidents severity: the severity of the incident(1 → Low Impact, 2 → Minor, 3 → Moderate, 4 → Serious) type: the type of the incident(1 → Accident, 2 → Congestion, 3 → Disabled Vehicle, 4 → Mass Transit, 5 → Miscellaneous, 6 → Other News, 7 → Planned Event, 8 → Road Hazard, 9 → Construction, 10 → Alert, 11 → Weather) verified: if the incident is confirmed by an official source start: the date when the incident occurred end: the date when the incident will end loc: the location of the incident (latitude and longitude)
DOI: 10.6084/m9.figshare.1434687.v1
title: MongoDB metadata for dataset "Trend of traffic incidents in Europe and North America on the 3rd of July 2015"

description: MongoDB metadata for dataset "Trend of traffic incidents in Europe and North America on the 3rd of July 2015"(see first link)
DOI: 10.6084/m9.figshare.1434692.v4
title: Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

description: Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN <i>in vivo</i> and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN for 21 d exhibited the impaired glucose tolerance and insulin sensitivity, remarkable ER stress as well as attenuated insulin signaling in liver and adipose tissue but not in skeletal muscle. Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN. Consistent with these findings <i>in vivo</i>, we also observed that PGRN treatment induced ER stress, impaired insulin signaling in cultured hepatocytes and adipocytes, with such effects being partially nullified by blockade of PERK. Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2α axis of the ER stress response in action of PGRN. Collectively, our findings supported the notion that PGRN is a key regulator of insulin resistance and that PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2α dependent pathway.
DOI: 10.6084/m9.figshare.1434667
title: Applications of Metals and alloys in various industries

description: With the advancement of technologies, the modern industries like aerospace, aviation, oil & gas, nuclear power, electronic and electric, heat treating, medical and high tech industries are interested in using economical and high performance materials. This leads to use of materials in the more vigorous industrial conditions at the high temperatures where traditional materials can hardly be employed. Nowadays manufacturers and nickel suppliers are more focused in meeting the tough needs of demanding industries with the well fabricated materials that can withstand in the high temperature and severely corrosive conditions for the prolong period such as Monel, Inconel, Incoloy and Hastelloy alloys. In the chemical processing plants, alloys that are preferred for use are nickel - chromium alloys, nickel - copper alloys, copper – nickel alloys, iron- nickel – chromium alloys, austenitic chromium – nickel steels and stainless steels. These materials can be suitably used in handling the alkali products such as caustic soda, caustic potash and others. Deep oil and well plants include high temperature and pressure conditions where nickel based superalloys such as Inconel 625, Incoloy 825 and Hastelloy alloys. The pure metals and alloys for Aerospace engineering are titanium, Inconel 617, Inconel 718, Inconel X750, Nimonic 90, Nilo 36 and Incoloy A286. Inconel and Incoloy alloys are commonly used in gas turbines in aircraft engines. The nuclear power production industries commonly use the alloys- nimonic 75, nimonic 80A, alloy 718, alloy 600, alloy 617 and alloy X750. Nickel alloys are also significantly used in other high temperature and critical application industries such as welding, pollution and waste treatment, thermal processing, petro processing and electric and telecom.
DOI: 10.6084/m9.figshare.1434692.v6
title: Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

description: Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN <i>in vivo</i> and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN for 21 d exhibited the impaired glucose tolerance and insulin sensitivity, remarkable ER stress as well as attenuated insulin signaling in liver and adipose tissue but not in skeletal muscle. Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN. Consistent with these findings <i>in vivo</i>, we also observed that PGRN treatment induced ER stress, impaired insulin signaling in cultured hepatocytes and adipocytes, with such effects being partially nullified by blockade of PERK. Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2α axis of the ER stress response in action of PGRN. Collectively, our findings supported the notion that PGRN is a key regulator of insulin resistance and that PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2α dependent pathway.
DOI: 10.6084/m9.figshare.1434692.v5
title: Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

description: Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN <i>in vivo</i> and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN for 21 d exhibited the impaired glucose tolerance and insulin sensitivity, remarkable ER stress as well as attenuated insulin signaling in liver and adipose tissue but not in skeletal muscle. Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN. Consistent with these findings <i>in vivo</i>, we also observed that PGRN treatment induced ER stress, impaired insulin signaling in cultured hepatocytes and adipocytes, with such effects being partially nullified by blockade of PERK. Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2α axis of the ER stress response in action of PGRN. Collectively, our findings supported the notion that PGRN is a key regulator of insulin resistance and that PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2α dependent pathway.
DOI: 10.6084/m9.figshare.1434662
title: Metabolomics analysis reveals that AICAR affects glycerolipid, ceramide and nucleotide synthesis pathways in INS-1 Cells

description: This is relevant raw data and the heatmap for the paper published in Plos One with title " Metabolomics analysis reveals that AICAR affects glycerolipid, ceramide and nucleotide synthesis pathways in INS-1 Cells"
DOI: 10.6084/m9.figshare.1434661
title: SNP matrix for 73 Agona genomes

description: A SNP matrix for Zhou et al. 2012, PLoS Genetics.
DOI: 10.6084/m9.figshare.1434662.v1
title: Metabolomics analysis reveals that AICAR affects glycerolipid, ceramide and nucleotide synthesis pathways in INS-1 Cells

description: This is relevant raw data and the heatmap for the paper published in Plos One with title " Metabolomics analysis reveals that AICAR affects glycerolipid, ceramide and nucleotide synthesis pathways in INS-1 Cells"
DOI: 10.6084/m9.figshare.1434661.v1
title: SNP matrix for 73 Agona genomes

description: A SNP matrix for Zhou et al. 2012, PLoS Genetics.
DOI: 10.6084/m9.figshare.1434648
title: Out of Africa: did Emys orbicularis occidentaliscross the Strait of Gibraltar twice?

description: The narrow Strait of Gibraltar has separated the African and European continents since the Miocene (5.3 Mya), with a different degree of permeability for Mediterranean taxa. Southern and northern regions of the Iberian Peninsula and Morocco, respectively, are key areas to evaluate the colonization dynamics and biogeographic history of taxa occurring at both sides of this strait. The Ibero-Maghrebian subspecies of the European pond turtle, <em>Emys orbicularis occidentalis</em>, is patchily distributed and threatened throughout most of the Iberian Peninsula and northern Morocco and its origin is thought to be in North Africa. Here we expand the geographic sampling across the Iberian Peninsula and Morocco, with special emphasis in the southern tip of the peninsula and northern Morocco, and analyze mtDNA sequences of 183 <em>E. o. occidentalis </em>to better understand the complex biogeographic history of this subspecies. We provide for the first time evidence for shared haplotypes of Iberian and North African pond turtles, with an additional haplotype in the southern Iberian Peninsula derived from Moroccan haplotypes. This supports the hypothesis that the Strait of Gibraltar constitutes no significant biogeographic barrier for <em>E. orbicularis</em>. However, the newly discovered shared, or extremely similar, haplotypes of European pond turtles from the southern Iberian Peninsula and Morocco suggest either that at least two independent natural colonization waves from Morocco have reached the Iberian Peninsula or that Moroccan turtles were accidentally or deliberately introduced there.
DOI: 10.6084/m9.figshare.1434648.v1
title: Out of Africa: did Emys orbicularis occidentaliscross the Strait of Gibraltar twice?

description: The narrow Strait of Gibraltar has separated the African and European continents since the Miocene (5.3 Mya), with a different degree of permeability for Mediterranean taxa. Southern and northern regions of the Iberian Peninsula and Morocco, respectively, are key areas to evaluate the colonization dynamics and biogeographic history of taxa occurring at both sides of this strait. The Ibero-Maghrebian subspecies of the European pond turtle, <em>Emys orbicularis occidentalis</em>, is patchily distributed and threatened throughout most of the Iberian Peninsula and northern Morocco and its origin is thought to be in North Africa. Here we expand the geographic sampling across the Iberian Peninsula and Morocco, with special emphasis in the southern tip of the peninsula and northern Morocco, and analyze mtDNA sequences of 183 <em>E. o. occidentalis </em>to better understand the complex biogeographic history of this subspecies. We provide for the first time evidence for shared haplotypes of Iberian and North African pond turtles, with an additional haplotype in the southern Iberian Peninsula derived from Moroccan haplotypes. This supports the hypothesis that the Strait of Gibraltar constitutes no significant biogeographic barrier for <em>E. orbicularis</em>. However, the newly discovered shared, or extremely similar, haplotypes of European pond turtles from the southern Iberian Peninsula and Morocco suggest either that at least two independent natural colonization waves from Morocco have reached the Iberian Peninsula or that Moroccan turtles were accidentally or deliberately introduced there.
DOI: 10.6084/m9.figshare.1434641
title: Bitcoin Rates

description: Represents the bitcoin rates for the last few days in different currencies. Have been fetched from bitcoinaverage.com API within a Taverna Workbench Workflow
DOI: 10.6084/m9.figshare.1434641.v1
title: Bitcoin Rates

description: Represents the bitcoin rates for the last few days in different currencies. Have been fetched from bitcoinaverage.com API within a Taverna Workbench Workflow
DOI: 10.6084/m9.figshare.1434635
title: Mothership : (M)otherness and authorship in Tainted Love by Stewart Home

description: Mothership : (M)otherness and authorship in Tainted Love by Stewart Home Nikolina Nedeljkov Candidate in the PhD Program in English The Graduate Center, The City University of New York The paper based on the dissertation chapter presented at the conference Motherhood and creative practice: Maternal structures in creative work held on 1-2 June 2015 at London South Bank University
DOI: 10.6084/m9.figshare.1434634
title: Database for Verbs in the Dead Sea Scrolls

description: In this volume, Ken M. Penner uses an empirical method to establish that the Qumran authors’ selection of finite verb forms is determined not by aspect, but by tense or modality.
DOI: 10.6084/m9.figshare.1434046
title: The vocal communication of the mongoose lemur (<i>Eulemur mongoz</i>): phonation mechanisms, acoustic features and quantitative analysis

description: We recorded vocalisations of wild <i>Eulemur mongoz</i> groups in Madagascar and the Comoros Islands, as well as from habituated captive groups housed in European and Madagascan zoos. Each vocalisation was quantitatively described by means of an acoustic analysis procedure implemented in Praat, and vocal types were distinguished both by ear and by the visual screening of spectrograms. Vocal signals were then associated with the context in which they were produced, to explore whether they occur only in specific behavioural contexts or are uttered in a range of situations. We found that mongoose lemurs possess highly context-specific aerial alarm calls and territorial calls, while the ‘croui-croui’ is usually emitted to communicate between individuals regrouping at sunset. The other calls we recorded, such as those including low-pitched pulse trains sometimes followed by harmonic elements, were not tightly associated with a particular context. Mongoose lemur utterances included calls produced with closed mouths and the involvement of nasal resonance, or with constant degrees of mouth opening or mandible ‘articulation’ during phonation. We observed 15 vocal types, nine of which were entered into a multivariate model that classified vocal types with a high degree of reliability. The second and third formants played an important role in discriminating among types of calls.
DOI: 10.6084/m9.figshare.1434046.v1
title: The vocal communication of the mongoose lemur (<i>Eulemur mongoz</i>): phonation mechanisms, acoustic features and quantitative analysis

description: We recorded vocalisations of wild <i>Eulemur mongoz</i> groups in Madagascar and the Comoros Islands, as well as from habituated captive groups housed in European and Madagascan zoos. Each vocalisation was quantitatively described by means of an acoustic analysis procedure implemented in Praat, and vocal types were distinguished both by ear and by the visual screening of spectrograms. Vocal signals were then associated with the context in which they were produced, to explore whether they occur only in specific behavioural contexts or are uttered in a range of situations. We found that mongoose lemurs possess highly context-specific aerial alarm calls and territorial calls, while the ‘croui-croui’ is usually emitted to communicate between individuals regrouping at sunset. The other calls we recorded, such as those including low-pitched pulse trains sometimes followed by harmonic elements, were not tightly associated with a particular context. Mongoose lemur utterances included calls produced with closed mouths and the involvement of nasal resonance, or with constant degrees of mouth opening or mandible ‘articulation’ during phonation. We observed 15 vocal types, nine of which were entered into a multivariate model that classified vocal types with a high degree of reliability. The second and third formants played an important role in discriminating among types of calls.
DOI: 10.5281/zenodo.4015338
title: Chameleon KVM cloud traces (2020-09-04)

description: This cloud trace contains Nova compute events for the OpenStack KVM cloud on the Chameleon testbed since it was built in 2015. Several text fields have been anonymized to hide user information. This is the last set of traces for the KVM cloud built in 2015 in a file "chameleon_legacy_kvm_tacc_2020_02_03.zip". Chameleon deprecated the legacy KVM site in February 2020 and future versions of this deposition will not include this historical trace data. This trace contains data from 2015-09-17T15:37:05.000Z until 2020-02-03T06:23:40.000Z. The epoch time for timestamps is 2015-09-06T00:00:00. It follows version 0.3 of the cloud trace format. You can find more information and trace datasets at Science Clouds.
description: Please contact the data owner for using this data for any research purpose prior to release and acknowledge the source of the data in any published material based on it.
description: {"references": ["Keahey, Kate, et al. \"Chameleon: a scalable production testbed for computer science research.\" Contemporary High Performance Computing. CRC Press, 2019. 123-148."]}
DOI: 10.6084/m9.figshare.1434045
title: Villin folding contact maps

description: Training and test sets ~1M, 595-element binary valued contact maps for Villin folding trajectories Produced for C-alpha contacts below 8AA. ASCII-encoded, one line per contact map.