DOI: 10.5061/dryad.f1vhhmh52
title: Effects of phloretin, ritonavir, indinavir and Bay-876 on glucose transport during peritoneal dialysis in Sprague-Dawley rats

description: We previously found that phloretin, a general blocker of facilitative
 glucose channels (GLUTs), reduced glucose absorption and improved
 ultrafiltration during peritoneal dialysis (PD) in rats. It is as yet
 unknown via which GLUTs such transport occurs and whether transport occurs
 in a trans-cellular fashion. This study was undertaken to elucidate (i)
 whether glucose may be transferred in a trans-cellular fashion across
 peritoneal cells and (ii) via which GLUTs glucose transport may be partly
 mediated during PD. The main study was performed in thirty-two
 Sprague-Dawley rats in which PD was performed by instillation of 20 mL
 2.3% glucose PD fluid which was allowed to dwell for 60 min. Animals were
 given an IV infusion of [18F]-deoxyglucose allowing us to monitor glucose
 transport in both directions: from the dialysate to the circulation and
 vice versa. Animals received either no treatment (control), or received
 intra-peritoneal phloretin (50 mg/L), ritonavir (60 mg/L), or BAY-876 (25
 mg/L). Water and transfer of low-molecular solutes were closely monitored
 during dialysis. Additional experiments were then performed in sixteen
 rats using receiving either no treatment (control) or intra-peritoneal
 indinavir (50 mg/L). 
description: GENERAL INFORMATION 1. Title of Dataset: Effects of Phloretin, Ritonavir,
 Indinavir, and BAY-876 on Glucose Transport During Peritoneal Dialysis in
 Sprague-Dawley Rats 2. Author Information A. Principal Investigator
 Contact Information Name: Carl Öberg Institution: Lund University, Medical
 Faculty Address: Box 117, SE-221 00 Email:
 [carl.oberg@med.lu.se](mailto:carl.oberg@med.lu.se) 3. Date of data
 collection June 2022 to September 2023 4. Geographic location of data
 collection: Lund, Sweden 5. Information about funding sources that
 supported the collection of the data: Funding by the Crafoord Foundation,
 Lund University Medical Faculty Foundation grant YF 2020-YF0056, and The
 Inga-Britt and Arne Lundberg’s Research Foundation (all to C.M. Öberg).
 ### DATA & FILE OVERVIEW 1. File List: fdgdata.xls, indinavir.xls
 **DATA-SPECIFIC INFORMATION FOR: fdgdata.xls** 1. Number of variables: 130
 2. Number of cases/rows: 32 3. Variable List: animal, "unique number
 assigned to each animal" treatment, "Dialysis fluid used, e.g.
 LowNa 1.5% represents low sodium and 1.5% glucose strength" weight,
 "Body weight in grams before dialysis" date, "Date of the
 experiment YYYY-MM-DD" vin, "Peritoneal dialysis fluid volume
 instilled in milliliters" vout, "Peritoneal dialysis fluid
 volume extracted in milliliters (see manuscript for details)" uvol,
 "Total urine volume" ufdgcpm,"18-F activity in urine sample
 Bq/mL" p_na_before, "Plasma sodium concentration before dialysis
 in mmol/L" p_k_before, "Plasma potassium concentration before
 dialysis in mmol/L" p_cl_before, "Plasma chloride concentration
 before dialysis in mmol/L" p_ica_before, "Plasma ionized calcium
 concentration before dialysis in mmol/L" p_tco2_before, "Plasma
 total carbon dioxide concentration before dialysis in mmol/L"
 p_glu_before, "Plasma glucose concentration before dialysis in
 mmol/L" p_urea_before, "Plasma urea concentration before
 dialysis in mmol/L" p_crea_before, "Plasma creatinine
 concentration before dialysis in mmol/L" map_before, "Mean
 arterial pressure before dialysis in mmol/L" hr_before, "Heart
 rate before dialysis in mmol/L" p_na_after, "Plasma sodium
 concentration after dialysis in mmol/L" p_k_after, "Plasma
 potassium concentration after dialysis in mmol/L" p_cl_after,
 "Plasma chloride concentration after dialysis in mmol/L"
 p_ica_after, "Plasma ionized calcium concentration after dialysis in
 mmol/L" p_tco2_after, "Plasma total carbon dioxide concentration
 before dialysis in mmol/L" p_glu_after, "Plasma glucose
 concentration after dialysis in mmol/L" p_urea_after, "Plasma
 urea concentration after dialysis in mmol/L" p_crea_after,
 "Plasma creatinine concentration after dialysis in mmol/L"
 map_after, "Mean arterial pressure before dialysis in mmol/L"
 hr_after, "Heart rate before dialysis in mmol/L" n_p_samples,
 "Number of blood samples obtained during dialysis" pt1,
 "Time point for blood sample #1 in minutes post start of
 dialysis" pt2, "Time point for blood sample #2 in minutes post
 start of dialysis" pt3, "Time point for blood sample #3 in
 minutes post start of dialysis" pt4, "Time point for blood
 sample #4 in minutes post start of dialysis" pt5, "Time point
 for blood sample #5 in minutes post start of dialysis" pt6,
 "Time point for blood sample #6 in minutes post start of
 dialysis" hb_before, "Blood hemoglobin concentration before
 dialysis in g/L" hb_after, "Blood hemoglobin concentration after
 dialysis in g/L" hct_before, "Blood hematocrit before
 dialysis" hct_after, "Blood hematocrit after dialysis"
 p_fdg_1, "Plasma 18F activity (blood sample #1) in Bq/mL"
 p_fdg_2, "Plasma 18F activity (blood sample #2) in Bq/mL"
 p_fdg_3, "Plasma 18F activity (blood sample #3) in Bq/mL"
 p_fdg_4, "Plasma 18F activity (blood sample #4) in Bq/mL"
 p_fdg_5, "Plasma 18F activity (blood sample #5) in Bq/mL"
 p_fdg_6, "Plasma 18F activity (blood sample #6) in Bq/mL"
 n_d_samples, "Number of dialysate samples obtained during
 dialysis" d_sv_1, "Sampling volume for dialysate sample #1 in
 milliliters" d_sv_2, "Sampling volume for dialysate sample #2 in
 milliliters" d_sv_3, "Sampling volume for dialysate sample #3 in
 milliliters" d_sv_4, "Sampling volume for dialysate sample #4 in
 milliliters" d_sv_5, "Sampling volume for dialysate sample #5 in
 milliliters" d_sv_6, "Sampling volume for dialysate sample #6 in
 milliliters" d_sv_7, "Sampling volume for dialysate sample #7 in
 milliliters" d_fdg_1, "18F activity in dialysate sample #1 in
 Bq/mL" d_fdg_2, "18F activity in dialysate sample #2 in
 Bq/mL" d_fdg_3, "18F activity in dialysate sample #3 in
 Bq/mL" d_fdg_4, "18F activity in dialysate sample #4 in
 Bq/mL" d_fdg_5, "18F activity in dialysate sample #5 in
 Bq/mL" d_fdg_6, "18F activity in dialysate sample #6 in
 Bq/mL" d_fdg_7, "18F activity in dialysate sample #7 in
 Bq/mL" d_glu_0, "Measured glucose concentration in fresh
 dialysis fluid (before instillation) in mmol/L" d_glu_1,
 "Measured glucose concentration in dialysate sample #1 in
 mmol/L" d_glu_2, "Measured glucose concentration in dialysate
 sample #2 in mmol/L" d_glu_3, "Measured glucose concentration in
 dialysate sample #3 in mmol/L" d_glu_4, "Measured glucose
 concentration in dialysate sample #4 in mmol/L" d_glu_5,
 "Measured glucose concentration in dialysate sample #5 in
 mmol/L" d_glu_6, "Measured glucose concentration in dialysate
 sample #6 in mmol/L" d_glu_7, "Measured glucose concentration in
 dialysate sample #7 in mmol/L" d_na_0, "Measured sodium
 concentration in fresh dialysis fluid (before instillation) in
 mmol/L" d_na_1, "Measured glucose concentration in dialysate
 sample #1 in mmol/L" d_na_2, "Measured glucose concentration in
 dialysate sample #2 in mmol/L" d_na_3, "Measured glucose
 concentration in dialysate sample #3 in mmol/L" d_na_4,
 "Measured glucose concentration in dialysate sample #4 in
 mmol/L" d_na_5, "Measured glucose concentration in dialysate
 sample #5 in mmol/L" d_na_6, "Measured glucose concentration in
 dialysate sample #6 in mmol/L" d_na_7, "Measured glucose
 concentration in dialysate sample #7 in mmol/L" d_k_0, "Measured
 potassium concentration in fresh dialysis fluid (before instillation) in
 mmol/L" d_k_1, "Measured potassium concentration in dialysate
 sample #1 in mmol/L" d_k_2, "Measured potassium concentration in
 dialysate sample #2 in mmol/L" d_k_3, "Measured potassium
 concentration in dialysate sample #3 in mmol/L" d_k_4, "Measured
 potassium concentration in dialysate sample #4 in mmol/L" d_k_5,
 "Measured potassium concentration in dialysate sample #5 in
 mmol/L" d_k_6, "Measured potassium concentration in dialysate
 sample #6 in mmol/L" d_k_7, "Measured potassium concentration in
 dialysate sample #7 in mmol/L" d_cl_0, "Measured chloride
 concentration in fresh dialysis fluid (before instillation) in
 mmol/L" d_cl_1, "Measured chloride concentration in dialysate
 sample #1 in mmol/L" d_cl_2, "Measured chloride concentration in
 dialysate sample #2 in mmol/L" d_cl_3, "Measured chloride
 concentration in dialysate sample #3 in mmol/L" d_cl_4,
 "Measured chloride concentration in dialysate sample #4 in
 mmol/L" d_cl_5, "Measured chloride concentration in dialysate
 sample #5 in mmol/L" d_cl_6, "Measured chloride concentration in
 dialysate sample #6 in mmol/L" d_cl_7, "Measured chloride
 concentration in dialysate sample #7 in mmol/L" d_ica_0,
 "Measured ionized calcium concentration in fresh dialysis fluid
 (before instillation) in mmol/L" d_ica_1, "Measured ionized
 calcium concentration in dialysate sample #1 in mmol/L" d_ica_2,
 "Measured ionized calcium concentration in dialysate sample #2 in
 mmol/L" d_ica_3, "Measured ionized calcium concentration in
 dialysate sample #3 in mmol/L" d_ica_4, "Measured ionized
 calcium concentration in dialysate sample #4 in mmol/L" d_ica_5,
 "Measured ionized calcium concentration in dialysate sample #5 in
 mmol/L" d_ica_6, "Measured ionized calcium concentration in
 dialysate sample #6 in mmol/L" d_ica_7, "Measured ionized
 calcium concentration in dialysate sample #7 in mmol/L" d_tco2_0,
 "Measured total carbon dioxide concentration in fresh dialysis fluid
 (before instillation) in mmol/L" d_tco2_1, "Measured total
 carbon dioxide concentration in dialysate sample #1 in mmol/L"
 d_tco2_2, "Measured total carbon dioxide concentration in dialysate
 sample #1 in mmol/L" d_tco2_3, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_tco2_4,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_5, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_tco2_6,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_7, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_urea_1,
 "Measured urea concentration in dialysate sample #1 in mmol/L"
 d_urea_2, "Measured urea concentration in dialysate sample #2 in
 mmol/L" d_urea_3, "Measured urea concentration in dialysate
 sample #3 in mmol/L" d_urea_4, "Measured urea concentration in
 dialysate sample #4 in mmol/L" d_urea_5, "Measured urea
 concentration in dialysate sample #5 in mmol/L" d_urea_6,
 "Measured urea concentration in dialysate sample #6 in mmol/L"
 d_urea_7, "Measured urea concentration in dialysate sample #7 in
 mmol/L" d_crea_0, "Measured creatinine concentration in fresh
 dialysis fluid (before instillation) in μmol/L" d_crea_1,
 "Measured creatinine concentration in dialysate sample #1 in
 μmol/L" d_crea_2, "Measured creatinine concentration in
 dialysate sample #2 in μmol/L" d_crea_3, "Measured creatinine
 concentration in dialysate sample #3 in μmol/L" d_crea_4,
 "Measured creatinine concentration in dialysate sample #4 in
 μmol/L" d_crea_5, "Measured creatinine concentration in
 dialysate sample #5 in μmol/L" d_crea_6, "Measured creatinine
 concentration in dialysate sample #6 in μmol/L" d_crea_7,
 "Measured creatinine concentration in dialysate sample #7 in
 μmol/L" dt1, "Time point for dialysate sample #1 in minutes post
 start of dialysis" dt2, "Time point for dialysate sample #2 in
 minutes post start of dialysis" dt3, "Time point for dialysate
 sample #3 in minutes post start of dialysis" dt4, "Time point
 for dialysate sample #4 in minutes post start of dialysis" dt5,
 "Time point for dialysate sample #5 in minutes post start of
 dialysis" dt6, "Time point for dialysate sample #6 in minutes
 post start of dialysis" dt7, "Time point for dialysate sample #7
 in minutes post start of dialysis" * Missing data codes: NA
 **DATA-SPECIFIC INFORMATION FOR: indinavir.xls** 1. Number of variables:
 155 2. Number of cases/rows: 16 3. Variable List: animal, "unique
 number assigned to each animal" treatment, "Control (no
 treatment) or indinavir" weight_before, "Body weight in grams
 before dialysis" weight_after, "Body weight in grams after
 dialysis" date, "Date of the experiment YYYY-MM-DD" vin,
 "Peritoneal dialysis fluid volume instilled in milliliters"
 vout, "Peritoneal dialysis fluid volume extracted in milliliters (see
 manuscript for details)" wo_in, "Wash-out fluid volume instilled
 (typically 15 mL)" wo_out, "Wash-out fluid volume drained (see
 manuscript for details)" wo_alb, "125I activity in wash-out
 fluid in Bq/mL" uvol, "Total urine volume in mL" u_glu,
 "Urine glucose concentration in mmol/L" uristix, "Urine
 glucose concentration as indicated by a dipstick test (Uristix)"
 u_alb, "125I activity in urine in Bq/mL" u_edta, "51Cr
 activity in urine in Bq/mL" p_na_before, "Plasma sodium
 concentration before dialysis in mmol/L" p_k_before, "Plasma
 potassium concentration before dialysis in mmol/L" p_cl_before,
 "Plasma chloride concentration before dialysis in mmol/L"
 p_ica_before, "Plasma ionized calcium concentration before dialysis
 in mmol/L" p_tco2_before, "Plasma total carbon dioxide
 concentration before dialysis in mmol/L" p_glu_before, "Plasma
 glucose concentration before dialysis in mmol/L" p_urea_before,
 "Plasma urea concentration before dialysis in mmol/L"
 p_crea_before, "Plasma creatinine concentration before dialysis in
 mmol/L" map_before, "Mean arterial pressure before dialysis in
 mmol/L" hr_before, "Heart rate before dialysis in mmol/L"
 p_na_after, "Plasma sodium concentration after dialysis in
 mmol/L" p_k_after, "Plasma potassium concentration after
 dialysis in mmol/L" p_cl_after, "Plasma chloride concentration
 after dialysis in mmol/L" p_ica_after, "Plasma ionized calcium
 concentration after dialysis in mmol/L" p_tco2_after, "Plasma
 total carbon dioxide concentration before dialysis in mmol/L"
 p_glu_after, "Plasma glucose concentration after dialysis in
 mmol/L" p_urea_after, "Plasma urea concentration after dialysis
 in mmol/L" p_crea_after, "Plasma creatinine concentration after
 dialysis in mmol/L" map_after, "Mean arterial pressure before
 dialysis in mmol/L" hr_after, "Heart rate before dialysis in
 mmol/L" n_p_samples, "Number of blood samples obtained during
 dialysis" pt1, "Time point for blood sample #1 in minutes post
 start of dialysis" pt2, "Time point for blood sample #2 in
 minutes post start of dialysis" pt3, "Time point for blood
 sample #3 in minutes post start of dialysis" pt4, "Time point
 for blood sample #4 in minutes post start of dialysis" pt5,
 "Time point for blood sample #5 in minutes post start of
 dialysis" pt6, "Time point for blood sample #6 in minutes post
 start of dialysis" hb_before, "Blood hemoglobin concentration
 before dialysis in g/L" hb_after, "Blood hemoglobin
 concentration after dialysis in g/L" p_hct_1, "Blood hematocrit
 for blood sample #1 in minutes post start of dialysis" p_hct_2,
 "Blood hematocrit for blood sample #2 in minutes post start of
 dialysis" p_hct_3, "Blood hematocrit for blood sample #3 in
 minutes post start of dialysis" p_hct_4, "Blood hematocrit for
 blood sample #4 in minutes post start of dialysis" p_hct_5,
 "Blood hematocrit for blood sample #5 in minutes post start of
 dialysis" p_hct_6, "Blood hematocrit for blood sample #6 in
 minutes post start of dialysis" p_edta_1, "Plasma 51Cr activity
 (blood sample #1) in Bq/mL" p_edta_2, "Plasma 51Cr activity
 (blood sample #2) in Bq/mL" p_edta_3, "Plasma 51Cr activity
 (blood sample #3) in Bq/mL" p_edta_4, "Plasma 51Cr activity
 (blood sample #4) in Bq/mL" p_edta_5, "Plasma 51Cr activity
 (blood sample #5) in Bq/mL" p_edta_6, "Plasma 51Cr activity
 (blood sample #6) in Bq/mL" p_alb_1, "Plasma 125I activity
 (blood sample #1) in Bq/mL" p_alb_2, "Plasma 125I activity
 (blood sample #2) in Bq/mL" p_alb_3, "Plasma 125I activity
 (blood sample #3) in Bq/mL" p_alb_4, "Plasma 125I activity
 (blood sample #4) in Bq/mL" p_alb_5, "Plasma 125I activity
 (blood sample #5) in Bq/mL" p_alb_6, "Plasma 125I activity
 (blood sample #6) in Bq/mL" n_d_samples, "Number of dialysate
 samples obtained during dialysis" d_sv_1, "Sampling volume for
 dialysate sample #1 in milliliters" d_sv_2, "Sampling volume for
 dialysate sample #2 in milliliters" d_sv_3, "Sampling volume for
 dialysate sample #3 in milliliters" d_sv_4, "Sampling volume for
 dialysate sample #4 in milliliters" d_sv_5, "Sampling volume for
 dialysate sample #5 in milliliters" d_sv_6, "Sampling volume for
 dialysate sample #6 in milliliters" d_sv_7, "Sampling volume for
 dialysate sample #7 in milliliters" d_edta_0, "51Cr activity in
 dialysis fluid (before instillation) in Bq/mL" d_edta_1, "51Cr
 activity in dialysate sample #1 in Bq/mL" d_edta_2, "51Cr
 activity in dialysate sample #2 in Bq/mL" d_edta_3, "51Cr
 activity in dialysate sample #3 in Bq/mL" d_edta_4, "51Cr
 activity in dialysate sample #4 in Bq/mL" d_edta_5, "51Cr
 activity in dialysate sample #5 in Bq/mL" d_edta_6, "51Cr
 activity in dialysate sample #6 in Bq/mL" d_edta_7, "51Cr
 activity in dialysate sample #7 in Bq/mL" d_alb_0, "125I
 activity in dialysis fluid (before instillation) in Bq/mL" d_alb_1,
 "125I activity in dialysate sample #1 in Bq/mL" d_alb_2,
 "125I activity in dialysate sample #2 in Bq/mL" d_alb_3,
 "125I activity in dialysate sample #3 in Bq/mL" d_alb_4,
 "125I activity in dialysate sample #4 in Bq/mL" d_alb_5,
 "125I activity in dialysate sample #5 in Bq/mL" d_alb_6,
 "125I activity in dialysate sample #6 in Bq/mL" d_alb_7,
 "125I activity in dialysate sample #7 in Bq/mL" d_glu_1,
 "Measured glucose concentration in dialysate sample #1 in
 mmol/L" d_glu_2, "Measured glucose concentration in dialysate
 sample #2 in mmol/L" d_glu_3, "Measured glucose concentration in
 dialysate sample #3 in mmol/L" d_glu_4, "Measured glucose
 concentration in dialysate sample #4 in mmol/L" d_glu_5,
 "Measured glucose concentration in dialysate sample #5 in
 mmol/L" d_glu_6, "Measured glucose concentration in dialysate
 sample #6 in mmol/L" d_glu_7, "Measured glucose concentration in
 dialysate sample #7 in mmol/L" d_na_0, "Sodium concentration in
 fresh dialysis fluid (before instillation) in mmol/L" d_na_1,
 "Measured glucose concentration in dialysate sample #1 in
 mmol/L" d_na_2, "Measured glucose concentration in dialysate
 sample #2 in mmol/L" d_na_3, "Measured glucose concentration in
 dialysate sample #3 in mmol/L" d_na_4, "Measured glucose
 concentration in dialysate sample #4 in mmol/L" d_na_5,
 "Measured glucose concentration in dialysate sample #5 in
 mmol/L" d_na_6, "Measured glucose concentration in dialysate
 sample #6 in mmol/L" d_na_7, "Measured glucose concentration in
 dialysate sample #7 in mmol/L" d_k_0, "Potassium concentration
 in fresh dialysis fluid (before instillation) in mmol/L" d_k_1,
 "Measured potassium concentration in dialysate sample #1 in
 mmol/L" d_k_2, "Measured potassium concentration in dialysate
 sample #2 in mmol/L" d_k_3, "Measured potassium concentration in
 dialysate sample #3 in mmol/L" d_k_4, "Measured potassium
 concentration in dialysate sample #4 in mmol/L" d_k_5, "Measured
 potassium concentration in dialysate sample #5 in mmol/L" d_k_6,
 "Measured potassium concentration in dialysate sample #6 in
 mmol/L" d_k_7, "Measured potassium concentration in dialysate
 sample #7 in mmol/L" d_cl_0, "Chloride concentration in fresh
 dialysis fluid (before instillation) in mmol/L" d_cl_1,
 "Measured chloride concentration in dialysate sample #1 in
 mmol/L" d_cl_2, "Measured chloride concentration in dialysate
 sample #2 in mmol/L" d_cl_3, "Measured chloride concentration in
 dialysate sample #3 in mmol/L" d_cl_4, "Measured chloride
 concentration in dialysate sample #4 in mmol/L" d_cl_5,
 "Measured chloride concentration in dialysate sample #5 in
 mmol/L" d_cl_6, "Measured chloride concentration in dialysate
 sample #6 in mmol/L" d_cl_7, "Measured chloride concentration in
 dialysate sample #7 in mmol/L" d_ica_1, "Measured ionized
 calcium concentration in dialysate sample #1 in mmol/L" d_ica_2,
 "Measured ionized calcium concentration in dialysate sample #2 in
 mmol/L" d_ica_3, "Measured ionized calcium concentration in
 dialysate sample #3 in mmol/L" d_ica_4, "Measured ionized
 calcium concentration in dialysate sample #4 in mmol/L" d_ica_5,
 "Measured ionized calcium concentration in dialysate sample #5 in
 mmol/L" d_ica_6, "Measured ionized calcium concentration in
 dialysate sample #6 in mmol/L" d_ica_7, "Measured ionized
 calcium concentration in dialysate sample #7 in mmol/L" d_tco2_0,
 "Total carbon dioxide concentration in fresh dialysis fluid (before
 instillation) in mmol/L" d_tco2_1, "Measured total carbon
 dioxide concentration in dialysate sample #1 in mmol/L" d_tco2_2,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_3, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_tco2_4,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_5, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_tco2_6,
 "Measured total carbon dioxide concentration in dialysate sample #1
 in mmol/L" d_tco2_7, "Measured total carbon dioxide
 concentration in dialysate sample #1 in mmol/L" d_urea_1,
 "Measured urea concentration in dialysate sample #1 in mmol/L"
 d_urea_2, "Measured urea concentration in dialysate sample #2 in
 mmol/L" d_urea_3, "Measured urea concentration in dialysate
 sample #3 in mmol/L" d_urea_4, "Measured urea concentration in
 dialysate sample #4 in mmol/L" d_urea_5, "Measured urea
 concentration in dialysate sample #5 in mmol/L" d_urea_6,
 "Measured urea concentration in dialysate sample #6 in mmol/L"
 d_urea_7, "Measured urea concentration in dialysate sample #7 in
 mmol/L" d_crea_1, "Measured creatinine concentration in
 dialysate sample #1 in μmol/L" d_crea_2, "Measured creatinine
 concentration in dialysate sample #2 in μmol/L" d_crea_3,
 "Measured creatinine concentration in dialysate sample #3 in
 μmol/L" d_crea_4, "Measured creatinine concentration in
 dialysate sample #4 in μmol/L" d_crea_5, "Measured creatinine
 concentration in dialysate sample #5 in μmol/L" d_crea_6,
 "Measured creatinine concentration in dialysate sample #6 in
 μmol/L" d_crea_7, "Measured creatinine concentration in
 dialysate sample #7 in μmol/L" dt1, "Time point for dialysate
 sample #1 in minutes post start of dialysis" dt2, "Time point
 for dialysate sample #2 in minutes post start of dialysis" dt3,
 "Time point for dialysate sample #3 in minutes post start of
 dialysis" dt4, "Time point for dialysate sample #4 in minutes
 post start of dialysis" dt5, "Time point for dialysate sample #5
 in minutes post start of dialysis" dt6, "Time point for
 dialysate sample #6 in minutes post start of dialysis" dt7,
 "Time point for dialysate sample #7 in minutes post start of
 dialysis" * Missing data codes: NA