cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10527449
title: Dataset related to article "Can STEreotactic Body Radiation Therapy (SBRT) Improve the Prognosis of Unresectable Locally Advanced Pancreatic Cancer? Long-Term Clinical Outcomes, Toxicity and Prognostic Factors on 142 Patients (STEP Study) "

description: This record contains raw data related to article “Can STEreotactic Body Radiation Therapy (SBRT) Improve the Prognosis of Unresectable Locally Advanced Pancreatic Cancer? Long-Term Clinical Outcomes, Toxicity and Prognostic Factors on 142 Patients (STEP Study)"

Abstract



 Aim:  The gold standard of care for pancreatic adenocarcinoma is the integrated treatment of surgery and chemotherapy (ChT), but about 50% of patients present with unresectable disease. Our study evaluated the efficacy in terms of local control, survival and safety of stereotactic body radiation therapy (SBRT) in locally advanced pancreatic cancer (LAPC).

 Methods:  A retrospective study (STEP study) analyzed patients with LAPC treated with a dose of 45 Gy in 6 fractions. Local control (LC), distant progression free survival (DPFS), overall survival (OS) and toxicity were analyzed according to the Kaplan-Meier method.

 Results:  A total of 142 patients were evaluated. Seventy-six patients (53.5%) received induction ChT before SBRT. The median follow-up was 11 months. One-, 2- and 3-year LC rate was 81.9%, 69.1% and 58.5%. Median DPFS was 6.03 months; 1- and 2-year DPFS rate was 19.9% and 4.5%. Median OS was 11.6 months and 1-, 2- and 3-year OS rates were 45.4%, 16.1%, and 9.8%. At univariate analysis, performed by the log-rank test, age < 70 years (p = 0.037), pre-SBRT ChT (p = 0.004) and post-SBRT ChT (p = 0.019) were associated with better OS. No patients experienced G3 toxicity.

 Conclusion:  SBRT represents an effective and safe therapeutic option in the multimodal treatment of patients with LAPC in terms of increased LC. When SBRT was sequentially integrated with ChT, the treatment proved to be promising in terms of OS as well.
DOI: 10.5281/zenodo.10527457
title: Nutrient concentration and adsorption for laboratory and field experiment evaluating biochar as a potential tool to mitigate nutrient exports from managed boreal forest

description: Forest management in drained forested peatlands can negatively affect water quality due to the increase in exports of organic matter and nutrients. Therefore, new methods to alleviate this impact are needed. In laboratory conditions, biochar has been shown to be a strong sorbent of organic and inorganic nutrients due to its high surface area and ion-exchange capacity. However, evidence of the adsorption capacity in field conditions is lacking. Here, we studied the water purification performance of two different biochar feedstocks (wood- and garden residue-based) in a 10-day laboratory experiment where we incubated biochar with runoff water collected from drainage ditches in clear-cut peatland forests. We measured changes in pH and concentrations of inorganic phosphorus (PO4), total dissolved nitrogen (TDN), and dissolved organic carbon (DOC). The biochar with the best adsorbent capacity in the laboratory experiment was then tested in field conditions in a replicated catchment-scale experiment, where both clear-cutting and ditch cleaning were performed. We determined nutrient concentration of water at the inlet and outlet of biochar filters placed in outflow ditches of four catchments. We found that under laboratory conditions wood-based biochar efficiently adsorbed TDN and DOC, however, it released PO4. Furthermore, we found that the biochar filters reduced TDN and DOC concentration in field conditions. However, the percentage decrease in concentration was dependent on the initial concentrations of nutrients in the water and could be considered low. Moreover, we found that the biochar in the filters increased in TN content over the course of the experiment. This suggests that a wood-based biochar filter has the potential to be a water protection tool for reducing export of nutrients from catchments with high nutrient concentration. And that the biochar from the ditches could be applied back to the regenerating forest catchment as a potential soil amendment, closing the nutrient cycle.
DOI: 10.5281/zenodo.10527458
title: Nutrient concentration and adsorption for laboratory and field experiment evaluating biochar as a potential tool to mitigate nutrient exports from managed boreal forest

description: Forest management in drained forested peatlands can negatively affect water quality due to the increase in exports of organic matter and nutrients. Therefore, new methods to alleviate this impact are needed. In laboratory conditions, biochar has been shown to be a strong sorbent of organic and inorganic nutrients due to its high surface area and ion-exchange capacity. However, evidence of the adsorption capacity in field conditions is lacking. Here, we studied the water purification performance of two different biochar feedstocks (wood- and garden residue-based) in a 10-day laboratory experiment where we incubated biochar with runoff water collected from drainage ditches in clear-cut peatland forests. We measured changes in pH and concentrations of inorganic phosphorus (PO4), total dissolved nitrogen (TDN), and dissolved organic carbon (DOC). The biochar with the best adsorbent capacity in the laboratory experiment was then tested in field conditions in a replicated catchment-scale experiment, where both clear-cutting and ditch cleaning were performed. We determined nutrient concentration of water at the inlet and outlet of biochar filters placed in outflow ditches of four catchments. We found that under laboratory conditions wood-based biochar efficiently adsorbed TDN and DOC, however, it released PO4. Furthermore, we found that the biochar filters reduced TDN and DOC concentration in field conditions. However, the percentage decrease in concentration was dependent on the initial concentrations of nutrients in the water and could be considered low. Moreover, we found that the biochar in the filters increased in TN content over the course of the experiment. This suggests that a wood-based biochar filter has the potential to be a water protection tool for reducing export of nutrients from catchments with high nutrient concentration. And that the biochar from the ditches could be applied back to the regenerating forest catchment as a potential soil amendment, closing the nutrient cycle.
DOI: 10.5282/ubm/data.351
title: Supplementary Datasets for the Paper "A heated rock crack captures and polymerizes primordial DNA and RNA"

description: Previous versions of this dataset: 

Dirscherl, Christina Felicitas und Braun, Dieter: Supplementary Datasets for the Paper "A heated rock crack captures and polymerizes primordial DNA and RNA". 2022. Open Data LMU. 10.5282/ubm/data.326 (deposited 18. Okt. 2022 12:59) 

Dirscherl, Christina Felicitas and Braun, Dieter: Supplementary Datasets for the Paper "A heated rock crack captures and polymerizes primordial DNA and RNA". 2022. Open Data LMU. 10.5282/ubm/data.320 (deposited 12. Oct 2022 07:17)

Dirscherl, Christina Felicitas and Braun, Dieter: Supplementary Datasets for the Paper "A Heated Rock Pore Promotes Primordial DNA and RNA Polymerization". 2022. Open Data LMU. 10.5282/ubm/data.296 (deposited 16. Mar 2022 08:55)
DOI: 10.5281/zenodo.10527566
title: BARKAMOL AVLODNI TARBIYALASHDA MUSIQA MADANIYATINING PEDAGOGIK OMILLARI
DOI: 10.5281/zenodo.10527567
title: BARKAMOL AVLODNI TARBIYALASHDA MUSIQA MADANIYATINING PEDAGOGIK OMILLARI
DOI: 10.11583/dtu.23695065
title: Data set for "Volume compensation of large-deformation 3D-printed soft elastomeric elastocaloric regenerators"

description: <br>
This data set is for the article " Volume compensation of large-deformation 3D-printed soft elastomeric elastocaloric regenerators ".
<br>
The data contains the measured stress-strain responses, pressure change as a function of time to calulate the regeneraor volume changes, and the defomed fluid-channel coordinate from FE simulations presented in the article.
<br>
The data is structured as follows:
<br>
The mechanical data raw data of stress-strain behavior for the hyperelastic fitting constains in the folder "Hyperelstic fitting".
<br>
In the Volume-change measurements folder, the subdirectories are named accoriding to the loading rates, including Rate 1 (0.1 s-1) and Rate 2 (1 s-1). In each subdirectory, the corresponding pressure change, mechanical, ambient temperature data are given.
<br>
In the Volume-change simulations folder, the subdirectories are named according to the fluidic channel types. In each subdirectory the files are named accoding to the hyperelastic models name and the data files are named by the applied strains during the simulations. The final data files are the exported 3D coordinates of the fluidic channel nodes, in which the column refers to locX, locY, locZ, dispX, dispY, dispZ, forceX, forceY, forceZ, from the left to right.
DOI: 10.5281/zenodo.10527545
title: Dataset related to article "Percutaneous Computed Tomography (CT)-Guided Localization with Indocyanine Green for the Thoracoscopic Resection of Small Pulmonary Nodules"

description: This record contains raw data related to article “Percutaneous Computed Tomography (CT)-Guided Localization with Indocyanine Green for the Thoracoscopic Resection of Small Pulmonary Nodules"

Abstract



 Background:  The identification of small lung nodules is challenging during mini-invasive thoracic surgery. Unable to palpate them directly, surgeons have developed several methods to preoperatively localize pulmonary nodules, including the computed tomography-guided positioning of coils or metallic landmarks (hook wire) or bronchoscopic marking.

 Methods:  We present a series of patients scheduled for the video-assisted thoracoscopic sublobar resection of small pulmonary nodules, in which we performed preoperative percutaneous computed tomography (CT)-guided nodule localization through the injection of a mixture of indocyanine green and human albumin.

 Results:  A total of 40 patients underwent a preoperative CT-guided injection of indocyanine green followed by VATS resection within 24 h. Patients tolerated the procedure well, no pain medication was administrated, and no complications were observed during the marking procedure. All pulmonary nodules were easily detected and successfully resected.

 Conclusion:  the near-infrared dye marking solution of indocyanine green (ICG) with diluted human albumin was safe, effective, and easy to perform. The ICG solution has the potential to facilitate the accurate localization and resection of pulmonary nodules during VATS surgery, avoiding the risk of marker displacement/migration.
DOI: 10.5281/zenodo.10527544
title: Dataset related to article "Percutaneous Computed Tomography (CT)-Guided Localization with Indocyanine Green for the Thoracoscopic Resection of Small Pulmonary Nodules"

description: This record contains raw data related to article “Percutaneous Computed Tomography (CT)-Guided Localization with Indocyanine Green for the Thoracoscopic Resection of Small Pulmonary Nodules"

Abstract



 Background:  The identification of small lung nodules is challenging during mini-invasive thoracic surgery. Unable to palpate them directly, surgeons have developed several methods to preoperatively localize pulmonary nodules, including the computed tomography-guided positioning of coils or metallic landmarks (hook wire) or bronchoscopic marking.

 Methods:  We present a series of patients scheduled for the video-assisted thoracoscopic sublobar resection of small pulmonary nodules, in which we performed preoperative percutaneous computed tomography (CT)-guided nodule localization through the injection of a mixture of indocyanine green and human albumin.

 Results:  A total of 40 patients underwent a preoperative CT-guided injection of indocyanine green followed by VATS resection within 24 h. Patients tolerated the procedure well, no pain medication was administrated, and no complications were observed during the marking procedure. All pulmonary nodules were easily detected and successfully resected.

 Conclusion:  the near-infrared dye marking solution of indocyanine green (ICG) with diluted human albumin was safe, effective, and easy to perform. The ICG solution has the potential to facilitate the accurate localization and resection of pulmonary nodules during VATS surgery, avoiding the risk of marker displacement/migration.
DOI: 10.5281/zenodo.10527721
title: Dataset related to article "Right tracheal sleeve pneumonectomy with VV-ECMO assistance for non-small cell lung cancer through anterior thoracotomy: a single centre experience"

description: This record contains raw data related to article “Right tracheal sleeve pneumonectomy with VV-ECMO assistance for non-small cell lung cancer through anterior thoracotomy: a single centre experience"

Abstract



For a long time, non-small cell lung cancer (NSCLC) arising less than 2 cm distal to the carina has been usually considered unresectable and incurable with a radical or extended resection because of surgical technical difficulty and airway management. Recently, the introduction of more advanced surgical techniques, often including the use of extracorporeal life support (ECLS), has allowed us to extend the limits of conventional surgery, increasing the rate of complete surgical resection. ECLS also overcomes the limitation of conventional ventilation during complex tracheo-bronchial reconstruction, avoiding the presence of disturbing lines or tubes that obstruct the operative field during a challenging surgery. In this article, we share our experience in performing right tracheal sleeve pneumonectomy with veno-venous extracorporeal membrane oxygenation (VV-ECMO) in three cases by anterior right thoracotomy, reporting our tips and tricks.
DOI: 10.5281/zenodo.10527722
title: Dataset related to article "Right tracheal sleeve pneumonectomy with VV-ECMO assistance for non-small cell lung cancer through anterior thoracotomy: a single centre experience"

description: This record contains raw data related to article “Right tracheal sleeve pneumonectomy with VV-ECMO assistance for non-small cell lung cancer through anterior thoracotomy: a single centre experience"

Abstract



For a long time, non-small cell lung cancer (NSCLC) arising less than 2 cm distal to the carina has been usually considered unresectable and incurable with a radical or extended resection because of surgical technical difficulty and airway management. Recently, the introduction of more advanced surgical techniques, often including the use of extracorporeal life support (ECLS), has allowed us to extend the limits of conventional surgery, increasing the rate of complete surgical resection. ECLS also overcomes the limitation of conventional ventilation during complex tracheo-bronchial reconstruction, avoiding the presence of disturbing lines or tubes that obstruct the operative field during a challenging surgery. In this article, we share our experience in performing right tracheal sleeve pneumonectomy with veno-venous extracorporeal membrane oxygenation (VV-ECMO) in three cases by anterior right thoracotomy, reporting our tips and tricks.
DOI: 10.6084/m9.figshare.25019879
title: beetle_data_Laos_ORG-vs-CONV.csv

description: We present an updated version of our dataset for the classification of beetles into morphospecies. In this study, we examined beetle community composition in three organic and three conventional farming systems in Vientiane, Lao PDR. Our results indicate that beetle abundance was relatively consistent in both farm types, while species richness was higher in organic farming compared to conventional farming. Furthermore, predators were over 18 times more abundant, and insect pests 9 times less abundant, in organic farming, suggesting an enhanced pest control. Abundance and richness of beetles also exhibited seasonal variation during the year.These findings have enormous significance for the promotion of sustainable agriculture and the preservation of biodiversity in Southeast Asia and tropical countries in general, and they greatly advance our understanding of the ecological effects of various farming methods. They may also contribute to assisting government policy, particularly the Ministry of Agriculture, which plays a crucial role in promoting and supporting the development of organic agriculture in Lao PDR.
DOI: 10.34740/kaggle/dsv/7427474
title: Global Genomic Neurofibromatosis Neoplasia
DOI: 10.5281/zenodo.10527750
title: Link to dataset related to article "Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis"

description: This record contains raw data related to article “Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis"

Abstract



 Background:  Heart failure is typical in the elderly. Metabolic remodeling of cardiomyocytes underlies inexorable deterioration of cardiac function with aging: glycolysis increases at the expense of oxidative phosphorylation, causing an energy deficit contributing to impaired contractility. Better understanding of the mechanisms of this metabolic switching could be critical for reversing the condition.

 Methods:  To investigate the role of 3 histone modifications (H3K27ac, H3K27me3, and H3K4me1) in the metabolic remodeling occurring in the aging heart, we cross-compared epigenomic, transcriptomic, and metabolomic data from mice of different ages. In addition, the role of the transcriptional coactivator p300 (E1A-associated binding protein p300)/CBP (CREB binding protein) in cardiac aging was investigated using a specific inhibitor of this histone acetyltransferase enzyme.

 Results:  We report a set of species-conserved enhancers associated with transcriptional changes underlying age-related metabolic remodeling in cardiomyocytes. Activation of the enhancer region of Hk2-a key glycolysis pathway gene-was fostered in old age-onset mouse heart by pseudohypoxia, wherein hypoxia-related genes are expressed under normal O2 levels, via increased activity of P300/CBP. Pharmacological inhibition of this transcriptional coactivator before the onset of cardiac aging led to a more aerobic, less glycolytic, metabolic state, improved heart contractility, and overall blunting of cardiac decline.

 Conclusions:  Taken together, our results suggest how epigenetic dysregulation of glycolysis pathway enhancers could potentially be targeted to treat heart failure in the elderly.
DOI: 10.5281/zenodo.10527749
title: Link to dataset related to article "Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis"

description: This record contains raw data related to article “Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis"

Abstract



 Background:  Heart failure is typical in the elderly. Metabolic remodeling of cardiomyocytes underlies inexorable deterioration of cardiac function with aging: glycolysis increases at the expense of oxidative phosphorylation, causing an energy deficit contributing to impaired contractility. Better understanding of the mechanisms of this metabolic switching could be critical for reversing the condition.

 Methods:  To investigate the role of 3 histone modifications (H3K27ac, H3K27me3, and H3K4me1) in the metabolic remodeling occurring in the aging heart, we cross-compared epigenomic, transcriptomic, and metabolomic data from mice of different ages. In addition, the role of the transcriptional coactivator p300 (E1A-associated binding protein p300)/CBP (CREB binding protein) in cardiac aging was investigated using a specific inhibitor of this histone acetyltransferase enzyme.

 Results:  We report a set of species-conserved enhancers associated with transcriptional changes underlying age-related metabolic remodeling in cardiomyocytes. Activation of the enhancer region of Hk2-a key glycolysis pathway gene-was fostered in old age-onset mouse heart by pseudohypoxia, wherein hypoxia-related genes are expressed under normal O2 levels, via increased activity of P300/CBP. Pharmacological inhibition of this transcriptional coactivator before the onset of cardiac aging led to a more aerobic, less glycolytic, metabolic state, improved heart contractility, and overall blunting of cardiac decline.

 Conclusions:  Taken together, our results suggest how epigenetic dysregulation of glycolysis pathway enhancers could potentially be targeted to treat heart failure in the elderly.
DOI: 10.5281/zenodo.10527797
title: METHOD OF ASSESSMENT OF ENTREPRENEURIAL ABILITY BASED ON KEY PERFORMANCE INDICATORS (KPI)
DOI: 10.5281/zenodo.10527798
title: METHOD OF ASSESSMENT OF ENTREPRENEURIAL ABILITY BASED ON KEY PERFORMANCE INDICATORS (KPI)
DOI: 10.6084/m9.figshare.25020005
title: Aligned_SCGs_iFrame.faa

description: Aligned_SCGs_iFrame.faa
DOI: 10.6084/m9.figshare.25020005.v1
title: Aligned_SCGs_iFrame.faa

description: Aligned_SCGs_iFrame.faa
DOI: 10.5281/zenodo.10527810
title: CRIMINOLOGICAL ASPECTS OF FEMALE CRIMINALITY
DOI: 10.5281/zenodo.10527811
title: CRIMINOLOGICAL ASPECTS OF FEMALE CRIMINALITY
DOI: 10.5281/zenodo.10527827
title: INGLIZ  SHE'RIYATIDA KONSEPTUAL METAFORA KO'RINISHLARI.
DOI: 10.5281/zenodo.10527828
title: INGLIZ  SHE'RIYATIDA KONSEPTUAL METAFORA KO'RINISHLARI.
DOI: 10.5281/zenodo.10527802
title: Dataset related to article "Pilot study on a new endoscopic platform for colorectal endoscopic submucosal dissection"

description: This record contains raw data related to article “Pilot study on a new endoscopic platform for colorectal endoscopic submucosal dissection"

Abstract



 Background:  The endoscopic submucosal dissection (ESD) is a technically demanding and time-consuming procedure, with an increased risk of adverse events compared to standard endoscopic resection techniques. The main difficulties are related to the instability of the operating field and to the loss of traction. We aimed to evaluate in a pilot trial a new endoscopic platform [tissue retractor system (TRS); ORISE, Boston scientific Co., Marlborough, MA, USA], designed to stabilize the intraluminal space, and to provide tissue retraction and counter traction.

 Method:  We prospectively enrolled all consecutive patients who underwent an ESD for sigmoid/rectal lesions. The primary outcome was the rate of technical feasibility. Further technical aspects such as en-bloc and R0 resection rate, number of graspers used, circumferential incision time, TRS assemblage time, submucosal dissection time, and submucosal dissection speed were provided. Clinical outcomes (recurrence rate and adverse events) were recorded as well.

 Results:  In all, 10 patients (M/F 4/6, age: 70.4 ± 11.0 years old) were enrolled. Eight out of 10 lesions were located in the rectum. Average lesion size was 31.2 ± 2.7 mm, and mean lesion area was 1628.88 ± 205.3 mm2. The two sigmoid lesions were removed through standard ESD, because the platform assemblage failed after several attempts. All rectal lesions were removed in an en-bloc fashion. R0 resection was achieved in 7/8 (87.5%) patients in an average procedure time of 60.5 ± 23.3 min. None of the patients developed neither intraprocedural nor postprocedural adverse events.

 Conclusion:  TRS-assisted ESD is a feasible option when used in the rectum, with promising result in terms of efficacy and safety outcomes. Nevertheless, our pilot study underlines few technical limitations of the present platform that need to be overcome before the system could be widely and routinely used.