cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25934/pr00008316
title: Correlation Between Symptoms and Objective Measures of Disease Activity in Patients with Moderate to Severe Ulcerative Colitis and Crohn’s Disease

description: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) which carry a substantial burden on patients’ quality of life. Assessing disease activity in patients with IBD has traditionally included symptoms (or patient-reported outcomes [PROs]), visualization of the bowel mucosa at endoscopy, microscopic evaluation of inflammation (histology), and evaluating levels of biomarkers of inflammation in the blood (i.e., C-reactive protein [CRP] and stool (fecal calprotectin [FCP]). While symptom resolution is an important goal of therapy, the correlation between PROs and objective disease measures (i.e., endoscopy, histology, biomarkers) is poor.

Understanding the relationship between symptoms and endoscopic, histologic, and biomarker measures of disease is important for several reasons. First, clinical decisions such as treatment initiation or escalation are frequently made based on patient symptoms, although this may not be reflective of objective disease activity. Second, evaluating the efficacy of novel therapies in IBD clinical trials will rely on PROs. Third, understanding the relationship between symptoms and bowel healing will help inform decision-making by physicians, particularly during early treatment of IBD. Patients may have different preferences and consider medication attributes in addition to the likelihood of achieving remission, such as the speed of symptom improvement.

Individual patient data will help determine 
1. the correlation between symptoms and objective measures of healing; 
2. how effective different treatments are (treatment effect sizes) when assessed using different PROs and/or objective disease measures; and 
3. the speed of symptom resolution and objective measures of bowel healing with treatment, and their relationship to one another.
DOI: 10.5281/zenodo.7314523
title: [IO Islamic 2652] محبوب القلوب

description: <strong>Maḥbûb-alḳulûb.</strong> <strong>This manuscript is now IO Islamic 800 in the India Office collections.</strong> <strong>[metadata:</strong> <strong>Hermann Ethé</strong><strong><em>, </em></strong><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> <strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong> <strong>number 2652 here with notations and hyperlinks].</strong> 800 Maḥbûb-alḳulûb (محبوب القلوب). A collection of moral tales by Barkhwurdâr bin Maḥmûd Turkmân of Farâh, with the takhalluṣ Mumtâz, see fol. 1<sup>b</sup>, l. 2, and fol. 72<sup>a</sup>, l. 3. The title appears on fol. 72<sup>a</sup>, l. 6. It is in substance the same work as noticed in Rieu ii. p. 767 sq., but differs in so far as it is considerably smaller in extent and lacks the preface quoted there. The beginning (which differs from that in Rieu’s copy) is exactly the same as that of the Berlin copy (noticed by W. Pertsch, Berlin Cat., p. 317, No. 289), viz.: چهره پرداز عرائس حريم عجز و نياز و مصوّر نگار خانۀ فرنگ آب الخ. The short introduction on ff. 1<sup>b</sup>-2<sup>b</sup>, in which there is only mention of the author’s stay in Harât (fol. 2<sup>a</sup>, l. 12), refers exclusively to the <em>first story</em> of our collection, which begins on fol. 2<sup>b</sup>, and bears as title (see fol. 2<sup>a</sup>, l. 8): حكايت فيروزشاه مصرى و گنجور عابد (given as general title to the whole collection on the fly-leaf). The subdivisions consist of حكايت and باب, the latter nine in number (on ff. 22<sup>b</sup>, 38<sup>a</sup>, 40<sup>b</sup>, 50<sup>b</sup>, 61<sup>a</sup>, 66<sup>a</sup>, 69<sup>a</sup>, 71<sup>b</sup>, and 165<sup>a</sup>); the last bâb contains, as in Rieu’s copy, the story of Ra’nâ and Zîbâ ( باب از كتاب رعنا و زيبا). The author flourished under Minûćihrkhân’s governorship of Mashhad (A.H. 1034-1074=A.D. 1625-1664), see Rieu iii. p. 1093<sup>b</sup>. No date. The Maḥbûb-alḳulûb has been printed in Bombay, A.H. 1268. Bibliotheca Leydeniana. No. 2652, ff. 197, ll. 18; Nasta’lîḳ, by different hands, mixed with Shikasta; size, 12<sup>1/8</sup> in. by 7<sup>1/4</sup> in.
DOI: 10.5281/zenodo.7314522
title: [IO Islamic 2652] محبوب القلوب

description: <strong>Maḥbûb-alḳulûb.</strong> <strong>This manuscript is now IO Islamic 800 in the India Office collections.</strong> <strong>[metadata:</strong> <strong>Hermann Ethé</strong><strong><em>, </em></strong><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> <strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong> <strong>number 2652 here with notations and hyperlinks].</strong> 800 Maḥbûb-alḳulûb (محبوب القلوب). A collection of moral tales by Barkhwurdâr bin Maḥmûd Turkmân of Farâh, with the takhalluṣ Mumtâz, see fol. 1<sup>b</sup>, l. 2, and fol. 72<sup>a</sup>, l. 3. The title appears on fol. 72<sup>a</sup>, l. 6. It is in substance the same work as noticed in Rieu ii. p. 767 sq., but differs in so far as it is considerably smaller in extent and lacks the preface quoted there. The beginning (which differs from that in Rieu’s copy) is exactly the same as that of the Berlin copy (noticed by W. Pertsch, Berlin Cat., p. 317, No. 289), viz.: چهره پرداز عرائس حريم عجز و نياز و مصوّر نگار خانۀ فرنگ آب الخ. The short introduction on ff. 1<sup>b</sup>-2<sup>b</sup>, in which there is only mention of the author’s stay in Harât (fol. 2<sup>a</sup>, l. 12), refers exclusively to the <em>first story</em> of our collection, which begins on fol. 2<sup>b</sup>, and bears as title (see fol. 2<sup>a</sup>, l. 8): حكايت فيروزشاه مصرى و گنجور عابد (given as general title to the whole collection on the fly-leaf). The subdivisions consist of حكايت and باب, the latter nine in number (on ff. 22<sup>b</sup>, 38<sup>a</sup>, 40<sup>b</sup>, 50<sup>b</sup>, 61<sup>a</sup>, 66<sup>a</sup>, 69<sup>a</sup>, 71<sup>b</sup>, and 165<sup>a</sup>); the last bâb contains, as in Rieu’s copy, the story of Ra’nâ and Zîbâ ( باب از كتاب رعنا و زيبا). The author flourished under Minûćihrkhân’s governorship of Mashhad (A.H. 1034-1074=A.D. 1625-1664), see Rieu iii. p. 1093<sup>b</sup>. No date. The Maḥbûb-alḳulûb has been printed in Bombay, A.H. 1268. Bibliotheca Leydeniana. No. 2652, ff. 197, ll. 18; Nasta’lîḳ, by different hands, mixed with Shikasta; size, 12<sup>1/8</sup> in. by 7<sup>1/4</sup> in.
DOI: 10.6084/m9.figshare.21545136
title: Tabla comparativa sobre "Acciones Realizadas por Autoridades Electorales para el Reconocimiento de Derechos Políticos de Personas LGBT"

description: El Observatorio de Reformas Políticas en América Latina presenta la siguiente tabla comparativa sobre acciones realizadas por autoridades electorales para el reconocimiento de derechos políticos de personas LGBT. <br> Producto elaborado en el marco del Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) de la UNAM. Clave del proyecto: IN302122. Proyecto: “La capacidad de resiliencias de las democracias: elecciones y política en contexto de pandemia”, del Instituto de Investigaciones Jurídicas de la UNAM [Dir. Flavia Freidenberg].
DOI: 10.6084/m9.figshare.21545136.v1
title: Tabla comparativa sobre "Acciones Realizadas por Autoridades Electorales para el Reconocimiento de Derechos Políticos de Personas LGBT"

description: El Observatorio de Reformas Políticas en América Latina presenta la siguiente tabla comparativa sobre acciones realizadas por autoridades electorales para el reconocimiento de derechos políticos de personas LGBT. <br> Producto elaborado en el marco del Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) de la UNAM. Clave del proyecto: IN302122. Proyecto: “La capacidad de resiliencias de las democracias: elecciones y política en contexto de pandemia”, del Instituto de Investigaciones Jurídicas de la UNAM [Dir. Flavia Freidenberg].
DOI: 10.15139/s3/zol7q1
title: Subset of data used in Hino and Burke, 2021. The effect of information about climate risk on property values.

description: This contains several datasets used in: Hino, M. and Burke, M., 2021. The effect of information about climate risk on property values. Proceedings of the National Academy of Sciences, 118 (17). 10.1073/pnas.2003374118. Data contained here are regulatory flood hazard maps. Not all the code and data needed for replication are included here. See https://purl.stanford.edu/td021fz7393 for the full set of files.
DOI: 10.6084/m9.figshare.21506178
title: Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of New Drugs Against Human Topoisomerase I Receptor

description: Human Topoisomerase I (hTop1p) is a ubiquitous enzyme that relaxes supercoiled DNA through a conserved mechanism involving transient breakage, rotation, and binding. Htop1p is the molecular target of the chemotherapeutic drug camptothecin (CPT). It causes the hTop1p-DNA complex to slow down the binding process and clash with the replicative machinery during the S phase of the cell cycle, forcing cells to activate the apoptotic response. This gives hTop1p a central role in cancer therapy. Recently, two artesunic acid derivatives (compounds c6 and c7)have been proposed as promising inhibitors of hTop1p with possible antitumor activity. Classical molecular dynamics simulation was performed to assess the ability of the two compounds to maintain a stable binding pose over time. <br> The three folders contains files concerning the input and output data from the docking process of the compuonds candidates. <br> <strong>docking_structures_pdqt</strong>: obtained using autodock tools 4.2.6. <br> <strong>best_poses_output_docking</strong>: obtained using autodock vina 1.2.0. <br> <strong>docking_configuration_file</strong>: configuration files that define the receptor, ligand input, the center and size of the search space. <br> Authors: [Francesco Madeddu, Jessica Di Martino, Michele Pieroni, Davide Del Buono, Paolo Bottoni, Lorenzo Botta, Tiziana Castrignanò, and Raffaele Saladino]
DOI: 10.6084/m9.figshare.21506178.v3
title: Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of New Drugs Against Human Topoisomerase I Receptor

description: Human Topoisomerase I (hTop1p) is a ubiquitous enzyme that relaxes supercoiled DNA through a conserved mechanism involving transient breakage, rotation, and binding. Htop1p is the molecular target of the chemotherapeutic drug camptothecin (CPT). It causes the hTop1p-DNA complex to slow down the binding process and clash with the replicative machinery during the S phase of the cell cycle, forcing cells to activate the apoptotic response. This gives hTop1p a central role in cancer therapy. Recently, two artesunic acid derivatives (compounds c6 and c7)have been proposed as promising inhibitors of hTop1p with possible antitumor activity. Classical molecular dynamics simulation was performed to assess the ability of the two compounds to maintain a stable binding pose over time. <br> The three folders contains files concerning the input and output data from the docking process of the compuonds candidates. <br> <strong>docking_structures_pdqt</strong>: obtained using autodock tools 4.2.6. <br> <strong>best_poses_output_docking</strong>: obtained using autodock vina 1.2.0. <br> <strong>docking_configuration_file</strong>: configuration files that define the receptor, ligand input, the center and size of the search space. <br> Authors: [Francesco Madeddu, Jessica Di Martino, Michele Pieroni, Davide Del Buono, Paolo Bottoni, Lorenzo Botta, Tiziana Castrignanò, and Raffaele Saladino]
DOI: 10.5281/zenodo.7314533
title: A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

description: Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. Placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2,631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings. File descriptions: ppBMI_placenta_unadjustedmodel_NFJ.csv = EWAS summary statistics for the EWAS of ppBMI using the unadjusted model ppBMI_placenta_adjustedmodel_NFJ.csv = EWAS summary statistics for the EWAS of ppBMI using the adjusted model Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a Zenodo DOI generated for you go to ewascatalog.org/upload.
DOI: 10.5281/zenodo.7314511
title: Immune checkpoint molecule TIGIT regulates kidney T cell functions and mediates acute kidney injury

description: This dataset includes the single cell RNA-seq data associated with the publication listed in the title (abstract below).<br> <br> CellRanger.zip contains the raw transcript counts as produced by CellRanger. There is one folder per sample. The samples are indicated by the folder name (e.g. KO_Ctrl). <br> <br> We have also included .h5ad files that contain of cells that passed quality control, as described in the manuscript.<br> <br> adTIGIT_raw_031422.h5ad contains all passing cells and the raw counts, as well as cell annotations ('celltype')<br> <br> adTIGIT_Tonly_091421.h5ad contains only T cells, .X contains the normalized data and T-cell sub-type ('cluster').<br> <br> Abstract: T cells mediate pathologic and reparative processes during acute kidney injury (AKI) but exact mechanisms regulating kidney T cell functions are unclear. This study identified upregulation of the novel immune checkpoint molecule, TIGIT, on mouse and human kidney T cells following AKI. TIGIT-expressing kidney T cells produced proinflammatory cytokines and had effector and central memory phenotype. Kidney Tregs were predominantly TIGIT+ and reduced after ischemia reperfusion (IR) injury. TIGIT deficient mice had protection from both ischemic and nephrotoxic AKI. Single cell RNA sequencing led to discovery of possible downstream targets of TIGIT. TIGIT mediates AKI pathophysiology, is a promising target for developing AKI therapy, and is being increasingly studied in human cancer therapy trials.
DOI: 10.5281/zenodo.7314510
title: Immune checkpoint molecule TIGIT regulates kidney T cell functions and mediates acute kidney injury

description: This dataset includes the single cell RNA-seq data associated with the publication listed in the title (abstract below).<br> <br> CellRanger.zip contains the raw transcript counts as produced by CellRanger. There is one folder per sample. The samples are indicated by the folder name (e.g. KO_Ctrl). <br> <br> We have also included .h5ad files that contain of cells that passed quality control, as described in the manuscript.<br> <br> adTIGIT_raw_031422.h5ad contains all passing cells and the raw counts, as well as cell annotations ('celltype')<br> <br> adTIGIT_Tonly_091421.h5ad contains only T cells, .X contains the normalized data and T-cell sub-type ('cluster').<br> <br> Abstract: T cells mediate pathologic and reparative processes during acute kidney injury (AKI) but exact mechanisms regulating kidney T cell functions are unclear. This study identified upregulation of the novel immune checkpoint molecule, TIGIT, on mouse and human kidney T cells following AKI. TIGIT-expressing kidney T cells produced proinflammatory cytokines and had effector and central memory phenotype. Kidney Tregs were predominantly TIGIT+ and reduced after ischemia reperfusion (IR) injury. TIGIT deficient mice had protection from both ischemic and nephrotoxic AKI. Single cell RNA sequencing led to discovery of possible downstream targets of TIGIT. TIGIT mediates AKI pathophysiology, is a promising target for developing AKI therapy, and is being increasingly studied in human cancer therapy trials.
DOI: 10.25810/gvw5-ce89
title: TSIS-1 SIM V08 Solar Spectral Irradiance
DOI: 10.15151/esrf-es-998426068
title: IBS BAG

description: The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.
DOI: 10.5281/zenodo.7311992
title: Supporting data for the manuscript: "The Role of Mesoscale Cloud Morphology in the Shortwave Cloud Feedback"

description: This repository contains supporting data for the manuscript "The Role of Mesoscale Cloud Morphology in the Shortwave Cloud Feedback" in <em>Geophysical Research Letters</em>. Detailed descriptions of these datasets can be found in the manuscript text as well as in the file descriptions.
description: We acknowledge the World Climate Research Programme and its Working Group on Coupled Modelling for coordinating CMIP6; the climate modeling groups involved for their simulations; the Earth System Grid Federation (ESGF) for archiving and facilitating data usage; and the multiple funding agencies who support CMIP and ESGF efforts. Research by ILM is supported by the NOAA Climate and Global Change Postdoctoral Fellowship Program, administered by UCAR's Cooperative Programs for the Advancement of Earth System Science (CPAESS) under award NA18NWS4620043B. RW acknowledges support from the NASA MEASURES grant NASA0004-02 AM1 and NASA CloudSat and CALIPSO Science Team award 80NSSC19K1274.
DOI: 10.6084/m9.figshare.21545306
title: Introgression of Asian soybean rust resistant genes into elite soybean lines from Uruguay

description: Soybean is the main agricultural crop in Uruguay. One of the diseases with the greatest damage potential is Asian soybean rust, with estimated grain yield losses up 80% in the region. Throughout history, different authors have stated the importance of genetic resistance as a fundamental tool to decrease the adverse effects of phytopathogens, leading to agriculture sustainability. The objective of this work was to introduce rust resistance genes into elite lines of INIA’s soybean breeding program and to evaluate the enhanced resistance. Introgression of resistant genes was carried out in a greenhouse, through three backcrosses from F<sub>1</sub>. Two donors: Py7-1-47 and No6-12-B handed by JIRCAS with two resistant genes combinations (<i>Rpp1-b</i> + <i>Rpp5</i> and <i>Rpp4</i> +<i> Rpp5</i>, respectively) and three elite lines: SJ10-122-040, SJ10-158-039, and SJ10-173-072 from INIA’s breeding program were used. After each backcross, plants carrying both genes were selected with marker assisted selection. Each third backcross was self-pollinated (BC<sub>3</sub>F<sub>2</sub>) and single plant families were inoculated in the greenhouse. Percentage of rust resistant plants within the introgressed families ranged from 42% to 98%, compared to fully susceptible recurrent parents.
DOI: 10.6084/m9.figshare.21545306.v1
title: Introgression of Asian soybean rust resistant genes into elite soybean lines from Uruguay

description: Soybean is the main agricultural crop in Uruguay. One of the diseases with the greatest damage potential is Asian soybean rust, with estimated grain yield losses up 80% in the region. Throughout history, different authors have stated the importance of genetic resistance as a fundamental tool to decrease the adverse effects of phytopathogens, leading to agriculture sustainability. The objective of this work was to introduce rust resistance genes into elite lines of INIA’s soybean breeding program and to evaluate the enhanced resistance. Introgression of resistant genes was carried out in a greenhouse, through three backcrosses from F<sub>1</sub>. Two donors: Py7-1-47 and No6-12-B handed by JIRCAS with two resistant genes combinations (<i>Rpp1-b</i> + <i>Rpp5</i> and <i>Rpp4</i> +<i> Rpp5</i>, respectively) and three elite lines: SJ10-122-040, SJ10-158-039, and SJ10-173-072 from INIA’s breeding program were used. After each backcross, plants carrying both genes were selected with marker assisted selection. Each third backcross was self-pollinated (BC<sub>3</sub>F<sub>2</sub>) and single plant families were inoculated in the greenhouse. Percentage of rust resistant plants within the introgressed families ranged from 42% to 98%, compared to fully susceptible recurrent parents.
DOI: 10.34740/kaggle/dsv/4491168
title: Ethnic stigma in hiring
DOI: 10.6084/m9.figshare.21545316
title: Can Personality Traits Predict Likelihood of Compliance with COVID-19 Regulations?

description: Data set from surveys collected from 461 adults aged 18-99 years old and living in the United States during the time of the COVID-19 pandemic.
DOI: 10.5517/ccdc.csd.cc2cnpzq
title: CCDC 2194644: Experimental Crystal Structure Determination

description: Related Article: Arnold Ou, Alexandre N. Sobolev, Killugudi Swaminatha Iyer|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cnq0s
title: CCDC 2194645: Experimental Crystal Structure Determination

description: Related Article: Arnold Ou, Alexandre N. Sobolev, Killugudi Swaminatha Iyer|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.