cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24891714.v2
title: Supplemental Files

description: Supplementary Files for manuscript. <b>Supplementary Table S1. List of abbreviations used in manuscript. </b><b>S</b><b>upplementary Figure S1. Fiber characteristics of skeletal muscle biopsies from COCOA-PAD trial.</b> <b>A-C) </b>Change in average myofiber cross-sectional area (CSA) of Type I <b>(A)</b>, Type IIa <b>(B)</b>, and Type IIa/x <b>(C)</b> fibers from baseline to 6-month follow-up in PLA and COCOA groups. D-F) Change in fiber type frequency, % of total fibers that are Type I <b>(D)</b>, Type IIa <b>(E)</b>, or Type IIa/x <b>(F)</b>. <b>G)</b> Change in the proportion of Type I fibers (%) with central nuclei. Difference between groups tested using an independent t-test, n=5 in PLA, n=9 in COCOA, ns: not significant. <b>Supplementary Figure S2. Correlations between fiber characteristics, muscle measures, and walking performance from COCOA-PAD trial. </b><b>A-B) </b>Association between the fold change in HO-1 levels <b>(A) </b>or NQO1 levels <b>(B)</b> with the change in Type II fibers with central nuclei. <b>(C-D)</b> The association between the fold change in HO-1 levels <b>(C)</b> or NQO1 levels<b> (D) </b>with the fold change in UQCRC2 levels. <b>E)</b> Association between the fold change in UQCRC2 levels and the change in 6-minute walk distance (m) from baseline to 6-month follow-up. Association tested by Pearson correlation. COCOA points shown in green and PLA shown in gray. Line of best fit, R<sup>2</sup>, and p-values shown. <b>Supplementary Figure S3. PAD serum treatment and EPI treatment effects on myotubes. A)</b> OCR trace over time after injections of indicated mitochondrial respiration modulators in Control myotubes [CON, standard 2% horse serum (HS)], 10% pooled PAD serum-treated myotubes (PAD serum), and 10% pooled healthy participant serum-treated myotubes (Healthy serum). <b>B) </b>Quantification of maximal OCR (FCCP-stimulated), normalized to protein concentration. <b>C) </b>Hydrogen peroxide production, assessed by AmR fluorescence. Data expressed as fold-regulation relative to CON myotubes. Experiments are averages of 4 technical replicates. <b>D)</b> Representative Western blot of p-Nrf2 and Nrf2 levels in myotube lysates treated with increasing doses of EPI or sulforaphane (SFN) as a positive control. <b>E)</b> Quantification of p-Nrf2 levels after densitometric analysis of the levels of each sample normalized to corresponding Nrf2 (p-Nrf2/Nrf2), expressed as fold-regulation relative to CON (untreated, 0 μM). Difference between groups (n=2-3/group) tested using a one-way ANOVA, results of pairwise post-hoc analyses (Tukey’s) displayed as *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001. <br>
DOI: 10.6084/m9.figshare.24891714.v1
title: Cocoa flavanols, Nrf2 activation, and oxidative stress in peripheral artery disease: Mechanistic findings in muscle based on outcomes from a randomized trial

description: Supplementary Files for manuscript. <b>Supplementary Table S1. List of abbreviations used in manuscript. </b><b>S</b><b>upplementary Figure S1. Fiber characteristics of skeletal muscle biopsies from COCOA-PAD trial.</b> <b>A-C) </b>Change in average myofiber cross-sectional area (CSA) of Type I <b>(A)</b>, Type IIa <b>(B)</b>, and Type IIa/x <b>(C)</b> fibers from baseline to 6-month follow-up in PLA and COCOA groups. D-F) Change in fiber type frequency, % of total fibers that are Type I <b>(D)</b>, Type IIa <b>(E)</b>, or Type IIa/x <b>(F)</b>. <b>G)</b> Change in the proportion of Type I fibers (%) with central nuclei. Difference between groups tested using an independent t-test, n=5 in PLA, n=9 in COCOA, ns: not significant. <b>Supplementary Figure S2. Correlations between fiber characteristics, muscle measures, and walking performance from COCOA-PAD trial. </b><b>A-B) </b>Association between the fold change in HO-1 levels <b>(A) </b>or NQO1 levels <b>(B)</b> with the change in Type II fibers with central nuclei. <b>(C-D)</b> The association between the fold change in HO-1 levels <b>(C)</b> or NQO1 levels<b> (D) </b>with the fold change in UQCRC2 levels. <b>E)</b> Association between the fold change in UQCRC2 levels and the change in 6-minute walk distance (m) from baseline to 6-month follow-up. Association tested by Pearson correlation. COCOA points shown in green and PLA shown in gray. Line of best fit, R<sup>2</sup>, and p-values shown. <b>Supplementary Figure S3. PAD serum treatment and EPI treatment effects on myotubes. A)</b> OCR trace over time after injections of indicated mitochondrial respiration modulators in Control myotubes [CON, standard 2% horse serum (HS)], 10% pooled PAD serum-treated myotubes (PAD serum), and 10% pooled healthy participant serum-treated myotubes (Healthy serum). <b>B) </b>Quantification of maximal OCR (FCCP-stimulated), normalized to protein concentration. <b>C) </b>Hydrogen peroxide production, assessed by AmR fluorescence. Data expressed as fold-regulation relative to CON myotubes. Experiments are averages of 4 technical replicates. <b>D)</b> Representative Western blot of p-Nrf2 and Nrf2 levels in myotube lysates treated with increasing doses of EPI or sulforaphane (SFN) as a positive control. <b>E)</b> Quantification of p-Nrf2 levels after densitometric analysis of the levels of each sample normalized to corresponding Nrf2 (p-Nrf2/Nrf2), expressed as fold-regulation relative to CON (untreated, 0 μM). Difference between groups (n=2-3/group) tested using a one-way ANOVA, results of pairwise post-hoc analyses (Tukey’s) displayed as *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001. <br>
DOI: 10.6073/pasta/1c29da43c8e45b436132b2189489c9c8
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 12 meteorological station: 30-minute soil volumetric water content data: 2013 - ongoing

description: 30-minute Soil Moisture data at 10 cm at CSIS Block-12. Collection of soil volumetric water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured at 10 cm depth at 3 locations at each of the 4 plots per block. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded every 30 minutes at an automated meteorological station installed at Jornada LTER CSIS Block-12 site. This is an ONGOING dataset.
DOI: 10.6073/pasta/08769518a63d06dbb8908efd01e1ea5c
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 12 meteorological station: Daily average soil volumetric water content data: 2013 - ongoing

description: Daily Average of 30-minute Soil Volumetric Water Content data at 10 cm at CSIS Block-12. Collection of soil water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured every 30 minutes at 10 cm depth at 3 locations at each of the 4 plots per block and averaged for the daily value. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded at an automated meteorological station installed at Jornada LTER CSIS Block-12 site. This is an ONGOING dataset.
DOI: 10.5281/zenodo.10480304
title: SMART Demo Meshes

description: These meshes need to be downloaded to run the examples in the smart-comp-sci repo. To run the examples, these should be placed in a folder titled "meshes" in the main repo folder.
DOI: 10.5281/zenodo.10480303
title: SMART Demo Meshes

description: These meshes need to be downloaded to run the examples in the smart-comp-sci repo. To run the examples, these should be placed in a folder titled "meshes" in the main repo folder.
DOI: 10.25934/pr00009388
title: A Prospective Machine Learning Model for the Identification of Sepsis Endotypes

description: Sepsis is a leading cause of death in serious COVID patients with no FDA-approved therapeutic treatment and has a 40%+ mortality rate. Current research in the field of Sepsis indicates that there is heterogeneity (i.e., differences) in the treatment effects (HTE) amongst Sepsis patients. This HTE is one of the major reasons why numerous trials have failed to deliver effective therapies. 

Previous studies have only retrospectively identified the HTE amongst patients, but have not looked at this heterogeneity proactively. We have a differentiated approach where we intend to develop an machine learning-based model for the proactive determination of endotypes (sub-categories) of Sepsis patients. A proactive approach can be helpful to us through predictive enrichment, which seeks to identify patients that are most likely to benefit from a novel therapy. Predictive enrichment means that instead of treating all patients with sepsis in the same way, enrichment strategies aim to separate the patients according to the different factors that may be contributing to their disease.
 
Biomarkers are biological molecules found in blood, other bodily fluids, or tissue which represents a sign of a normal or abnormal process in the body. As a first step, we will potentially explore developing a composite score (a numerical score made up from individual scores assigned to each factor of interest) based on biomarkers and clinical variables measured in the emergency room (ER) and other point-of-care outcomes to distinguish between the two endotypes.

Through access to anonymized and de-identified patient data from the study, we will use statistical and machine learning methods to proactively determine endotypes of Sepsis patients. Confidentiality and privacy will be maintained by storing the study data in a secure, encrypted, and password-protected analysis environment at GEn1E Lifesciences. We also understand that the data will be provided in the secure Vivli research environment and we agree and abide by the data sharing policies and anonymization standards set by the data contributor. This proposed research does not involve the use of any other data sources other than the study data.
DOI: 10.34740/kaggle/dsv/7379099
title: Balochi Language to English Translation Dataset
DOI: 10.6073/pasta/33568a5f081fc0952c4bbbce8c367eb3
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 12 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-12 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.5066/p9tsdeac
title: Digital surfaces and site data of well-screen top and bottom altitudes defining the irrigation production zone of the Mississippi River Valley alluvial aquifer within the Mississippi Alluvial Plain project region

description: Site data contained in the ScrIntrvls_AllSrcRefs_AllWellsRev.csv dataset define the top and bottom altitudes of well screens in 64,763 irrigation wells completed in the Mississippi River Valley alluvial aquifer (MRVA) that constitute a production zone in the Mississippi Alluvial Plain (MAP) extending across the midwestern and southern United States from Illinois to Louisiana. Each well entry contains an Enumerated Domain Value of the Attribute Label SrcRefNo to identify the state environmental agency that contributed to the database, and enumerated values are associated with specific state agencies by using the Enumerated Domain Value Definition. Screen-top and -bottom altitudes and land surface are referenced (corrected) to the National Elevation Dataset (NED) 10-meter digital elevation model (DEM; https://nationalmap.gov/elevation.html). The dataset identifies 50,103 screen-bottom altitudes and 50,457 screen-top altitudes that were used in subsequent geostatistical estimation after spatial analytics filtered out duplicate-coordinate wells, geographic and stratigraphic outliers, and incongruities of screen-top and -bottom altitudes compared with DEM land-surface altitude and the published digital surface of the bottom altitude of the MRVA (https://doi.org/10.3133/sim3426). Well entries are indexed in the dataset to identify use in four regional geostatistical models that collectively encompass the MAP extent and provide gridded estimates of screen-top and-bottom altitudes and estimation uncertainty (estimation variance) associated with each gridded altitude estimate. Digital surfaces of screen-top and -bottom estimates and estimation variances are represented as raster datasets that were converted to netCDF format and conform with the previously published National Hydrologic Grid (https://doi.org/10.5066/F7P84B24) at one-kilometer resolution. This dataset contains high-quality map images for gridded estimates of MRVA screen-top and -bottom altitude and for corresponding gridded estimation variances saved in the Tagged Image File (.tif) format.
DOI: 10.6073/pasta/b160a048babe3cc20503038400b64826
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 13 meteorological station: 30-minute summary data: 2017 - ongoing

description: This data package contains 30-minute air temperature, relative humidity, and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-1 met station. Average air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively. This is an ONGOING dataset.
DOI: 10.6084/m9.figshare.24112420
title: Clinical status of induction therapy incorporating a hypomethylating agent for newly diagnosed adult acute myeloid leukemia compared to the standard 7+3 regimen

description: Cytarabine and anthracycline combination therapy (7 + 3 regimen) is the standard care for induction chemotherapy in adult patients with acute myeloid leukemia (AML). Although this intensive regimen achieves a high response rate, it is highly toxic, especially in elderly or frail patients. Hypomethylating agents approved initially for high-risk myelodysplastic syndrome had longer survival times than conventional care in elderly patients with newly diagnosed AML. We summarize the latest information regarding induction therapy using hypomethylating agents (azacitidine and decitabine) for newly diagnosed AML. For untreated patients ineligible for an intensive regimen, a phase III trial exhibited the survival benefit of adding the highly selective BCL2 inhibitor venetoclax to azacitidine. The National Comprehensive Cancer Network guidelines recommend azacitidine or decitabine plus venetoclax as an option for patients with poor-risk AML, including those with <i>TP53</i> mutations and AML with the cytogenetic features of myelodysplastic syndrome. Future studies should evaluate positioning this combination as an induction therapy for younger patients eligible for hematopoietic stem cell transplantation. Without randomized trials, propensity score matching analysis suggested a comparable prognosis between azacitidine combination and intensive chemotherapy. Considering the feasibility of a doublet regimen incorporating azacitidine, a triplet regimen should be examined.
DOI: 10.6084/m9.figshare.24112420.v1
title: Clinical status of induction therapy incorporating a hypomethylating agent for newly diagnosed adult acute myeloid leukemia compared to the standard 7+3 regimen

description: Cytarabine and anthracycline combination therapy (7 + 3 regimen) is the standard care for induction chemotherapy in adult patients with acute myeloid leukemia (AML). Although this intensive regimen achieves a high response rate, it is highly toxic, especially in elderly or frail patients. Hypomethylating agents approved initially for high-risk myelodysplastic syndrome had longer survival times than conventional care in elderly patients with newly diagnosed AML. We summarize the latest information regarding induction therapy using hypomethylating agents (azacitidine and decitabine) for newly diagnosed AML. For untreated patients ineligible for an intensive regimen, a phase III trial exhibited the survival benefit of adding the highly selective BCL2 inhibitor venetoclax to azacitidine. The National Comprehensive Cancer Network guidelines recommend azacitidine or decitabine plus venetoclax as an option for patients with poor-risk AML, including those with <i>TP53</i> mutations and AML with the cytogenetic features of myelodysplastic syndrome. Future studies should evaluate positioning this combination as an induction therapy for younger patients eligible for hematopoietic stem cell transplantation. Without randomized trials, propensity score matching analysis suggested a comparable prognosis between azacitidine combination and intensive chemotherapy. Considering the feasibility of a doublet regimen incorporating azacitidine, a triplet regimen should be examined.
DOI: 10.6073/pasta/e5d16f8494667c24193636cd249b5574
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 13 meteorological station: 5-minute summary wind and air temperature data: 2013 - ongoing

description: This data package contains 5-minute air temperature and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-13 met station. Average air temperature, wind speed, and wind direction are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. This is a subset of baseline weather data collected at the 15 Jornada Basin LTER CSIS study blocks, New Mexico. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.5281/zenodo.10479278
title: Systematic Mapping Study on MLOps results

description: These are the last selection stage for the systematic mapping study on MLOps and the data extraction document used.
DOI: 10.5281/zenodo.10479279
title: Systematic Mapping Study on MLOps results

description: These are the last selection stage for the systematic mapping study on MLOps and the data extraction document used.
DOI: 10.6073/pasta/a516189c99488f3731eec87e1588304d
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 13 meteorological station: 1-hour summary data: 2017 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-13 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.5517/ccdc.csd.cc29hp9t
title: CCDC 2130236: Experimental Crystal Structure Determination

description: Related Article: Jianbo Song, Roman Pallach, Louis Frentzel‐Beyme, Pascal Kolodzeiski, Gregor Kieslich, Pia Vervoorts, Claire L. Hobday, Sebastian Henke|2022|Angew.Chem.,Int.Ed.|61|e202117565|doi:10.1002/anie.202117565
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc29hpbv
title: CCDC 2130237: Experimental Crystal Structure Determination

description: Related Article: Jianbo Song, Roman Pallach, Louis Frentzel‐Beyme, Pascal Kolodzeiski, Gregor Kieslich, Pia Vervoorts, Claire L. Hobday, Sebastian Henke|2022|Angew.Chem.,Int.Ed.|61|e202117565|doi:10.1002/anie.202117565
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc29hpcw
title: CCDC 2130238: Experimental Crystal Structure Determination

description: Related Article: Jianbo Song, Roman Pallach, Louis Frentzel‐Beyme, Pascal Kolodzeiski, Gregor Kieslich, Pia Vervoorts, Claire L. Hobday, Sebastian Henke|2022|Angew.Chem.,Int.Ed.|61|e202117565|doi:10.1002/anie.202117565
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc29hpdx
title: CCDC 2130239: Experimental Crystal Structure Determination

description: Related Article: Jianbo Song, Roman Pallach, Louis Frentzel‐Beyme, Pascal Kolodzeiski, Gregor Kieslich, Pia Vervoorts, Claire L. Hobday, Sebastian Henke|2022|Angew.Chem.,Int.Ed.|61|e202117565|doi:10.1002/anie.202117565
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.