cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31078762.v1
title: Supplementary Material for: Glyceryl trinitrate versus sham in the treatment of hyperacute stroke: the Efficacy of Nitric Oxide in Stroke-2 (ENOS-2) feasibility randomised controlled trial

description: Introduction
High blood pressure is associated with a poor outcome after stroke. Trials of transdermal glyceryl trinitrate (GTN), a nitric oxide donor, have suggested that treatment between 3 and 5 hours might improve functional outcome.

Methods
We randomly assigned hospitalised patients with an acute ischaemic or haemorrhagic stroke to two days of transdermal GTN (5 mg/day) or sham, started between 3 and 5 hours after onset. The primary feasibility outcome was recruitment rate; proof of concept was assessed at 90 days by central observers blinded to treatment assignment using the modified Rankin Scale (mRS). Data are number (%), median [interquartile range] or mean (standard deviation). Comparisons by multiple linear regression.

Results
39 of an intended 120 participants were recruited. A total of 3314 people were excluded, commonly related to presentation &gt;5 hours of onset or outside of researcher working hours, no eligible symptoms/signs or an unclear onset time. Mean age 72 (13) years, female 41%, blood pressure 161.8 (18.4)/80.8 (14.9) mmHg, time from onset at baseline 216 [186, 251] minutes. The fall in blood pressure over 24 hours did not differ between GTN versus sham. mRS at 3 months did not differ between the groups (difference in means, DIM -0.20, 95% confidence intervals -1.30, 0.90; p=0.72). GTN was associated with improved cognition on the telephone interview of cognition scale (DIM 8.0, 95% CI 1.3, 14.8; p=0.020). Although headache was more common, GTN was associated with fewer serious adverse events (p=0.020).

Conclusion
Recruitment limitations in this small single centre trial prevented demonstration of feasibility for patients in the time window of 3-5 hours post ictus. GTN demonstrated some evidence of proof-of-concept and was safe. A multicentre trial needs to further test this hypothesis.

Registration
ISRCTN17654248 Date: 31/3/2021
DOI: 10.6084/m9.figshare.31078765
title: Supplementary Material for: Differential Blood–Brain Barrier Permeability Driven by Asymmetric Hypoperfusion in a Vascular Dementia Model

description: Background: Blood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cerebral hypoperfusion. This study aims to investigate the effects of asymmetric hypoperfusion on BBB permeability using a mouse model of VaD.
Methods: Asymmetric bilateral carotid artery stenosis (ACAS) was induced using ligature rings. BBB integrity was assessed on 3 days post-surgery using Evans blue, IgG and albumin extravasation. A modified tissue processing protocol optimized endogenous markers detection. Regional and sex-based differences in BBB permeability were analyzed.
Results: Increased BBB permeability was observed in both corpus callosum and cortical areas, with significantly more severe leakage in the left cortex compared to the right, correlating directly with lower cerebral blood flow on the left side. In contrast, no significant asymmetrical difference in BBB permeability was detected in the corpus callosum. Additionally, male and female mice exhibited similar patterns of BBB permeability.
Conclusion: This study provides the first evidence that asymmetrical hypoperfusion significantly impacts regional BBB permeability in a mouse model of VaD. These findings highlight the importance of local hemodynamic changes in driving BBB dysfunction and underscore potential therapeutic targets for preventing or mitigating vascular dementia progression.
DOI: 10.6084/m9.figshare.31078765.v1
title: Supplementary Material for: Differential Blood–Brain Barrier Permeability Driven by Asymmetric Hypoperfusion in a Vascular Dementia Model

description: Background: Blood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cerebral hypoperfusion. This study aims to investigate the effects of asymmetric hypoperfusion on BBB permeability using a mouse model of VaD.
Methods: Asymmetric bilateral carotid artery stenosis (ACAS) was induced using ligature rings. BBB integrity was assessed on 3 days post-surgery using Evans blue, IgG and albumin extravasation. A modified tissue processing protocol optimized endogenous markers detection. Regional and sex-based differences in BBB permeability were analyzed.
Results: Increased BBB permeability was observed in both corpus callosum and cortical areas, with significantly more severe leakage in the left cortex compared to the right, correlating directly with lower cerebral blood flow on the left side. In contrast, no significant asymmetrical difference in BBB permeability was detected in the corpus callosum. Additionally, male and female mice exhibited similar patterns of BBB permeability.
Conclusion: This study provides the first evidence that asymmetrical hypoperfusion significantly impacts regional BBB permeability in a mouse model of VaD. These findings highlight the importance of local hemodynamic changes in driving BBB dysfunction and underscore potential therapeutic targets for preventing or mitigating vascular dementia progression.
DOI: 10.15468/dl.hzrnrg
title: Occurrence Download

description: A dataset containing 286 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ornithogalum umbellatum, Ornithogalum orthophyllum, Ornithogalum angustifolium, Ornithogalum angustifolium)",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "Year is greater than or equal to 2010",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "CoordinateUncertaintyInMeters is less than or equal to 50",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 286 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014194-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.31078768
title: Supplementary Material for: Coenzyme Q10 Supplementation in a Child with Biallelic COQ8A Variants: A Case Report

description: Pathogenic variants in COQ8A cause a rare form of primary coenzyme Q10 (CoQ10) deficiency that can lead to childhood-onset cerebellar ataxia and developmental delay. Reports of pediatric cases remain limited. We describe a 7-year-old boy with compound heterozygous COQ8A variants who presented with progressive cerebellar ataxia and intellectual disability. CoQ10 supplementation (10 mg/kg/day) was initiated after institutional ethics approval. During 1 year of therapy, the Scale for the Assessment and Rating of Ataxia (SARA) score improved from 17 to 9, serum CoQ10 concentration increased from 622 to 9,100 ng/mL, and mild cognitive improvement was noted (IQ 53 to 64). Brain MRI demonstrated cerebellar atrophy remained radiologically stable. No adverse effects were observed. This case highlights the clinical benefit and safety of CoQ10 supplementation in pediatric-onset COQ8A-related ataxia and emphasizes the importance of early genetic diagnosis and treatment initiation.
DOI: 10.6084/m9.figshare.31078768.v1
title: Supplementary Material for: Coenzyme Q10 Supplementation in a Child with Biallelic COQ8A Variants: A Case Report

description: Pathogenic variants in COQ8A cause a rare form of primary coenzyme Q10 (CoQ10) deficiency that can lead to childhood-onset cerebellar ataxia and developmental delay. Reports of pediatric cases remain limited. We describe a 7-year-old boy with compound heterozygous COQ8A variants who presented with progressive cerebellar ataxia and intellectual disability. CoQ10 supplementation (10 mg/kg/day) was initiated after institutional ethics approval. During 1 year of therapy, the Scale for the Assessment and Rating of Ataxia (SARA) score improved from 17 to 9, serum CoQ10 concentration increased from 622 to 9,100 ng/mL, and mild cognitive improvement was noted (IQ 53 to 64). Brain MRI demonstrated cerebellar atrophy remained radiologically stable. No adverse effects were observed. This case highlights the clinical benefit and safety of CoQ10 supplementation in pediatric-onset COQ8A-related ataxia and emphasizes the importance of early genetic diagnosis and treatment initiation.
DOI: 10.5281/zenodo.18269035
title: Optical Anomalies in Macroscopic  Vesicles: Empirical Evidence of Non Gaseous Internal Architecture in Common  Fluids

description: The classical physical model of ephemeral foam bubbles defines them as gas-filled cavities within a liquid matrix, governed by surface tension and strictly adhering to Plateau’s laws. According to standard geometric optics, such spherical interfaces under a single light source should exhibit a predictable, singular virtual image (specular reflection) on the convex surface. This study presents empirical data that challenges the universality of this model in common organic and inorganic fluid mediums (e.g., coffee infusions, salivary emulsions). Through a comparative analysis using macroscopic photography and high-magnification optical microscopy (up to 2000x), we identify a distinct class of vesicles herein termed Structured Vesicular Entities (SVEs). Unlike simple gas bubbles (Type-A), SVEs (Type-B) exhibit the "Multi-Focal Paradox"—simultaneous, non-concentric points of high luminosity within a single vesicular envelope—and a distinct internal opacity inconsistent with a homogeneous gas phase. This paper establishes a visual classification system distinguishing these two forms, proposing that SVEs represent a ubiquitous, selforganizing phenomenon possessing complex internal architecture.
DOI: 10.5281/zenodo.17911779
title: Optical Anomalies in Macroscopic  Vesicles: Empirical Evidence of Non Gaseous Internal Architecture in Common  Fluids

description: The classical physical model of ephemeral foam bubbles defines them as gas-filled cavities within a liquid matrix, governed by surface tension and strictly adhering to Plateau’s laws. According to standard geometric optics, such spherical interfaces under a single light source should exhibit a predictable, singular virtual image (specular reflection) on the convex surface. This study presents empirical data that challenges the universality of this model in common organic and inorganic fluid mediums (e.g., coffee infusions, salivary emulsions). Through a comparative analysis using macroscopic photography and high-magnification optical microscopy (up to 2000x), we identify a distinct class of vesicles herein termed Structured Vesicular Entities (SVEs). Unlike simple gas bubbles (Type-A), SVEs (Type-B) exhibit the "Multi-Focal Paradox"—simultaneous, non-concentric points of high luminosity within a single vesicular envelope—and a distinct internal opacity inconsistent with a homogeneous gas phase. This paper establishes a visual classification system distinguishing these two forms, proposing that SVEs represent a ubiquitous, selforganizing phenomenon possessing complex internal architecture.
DOI: 10.5281/zenodo.18208222
title: Notas de leitura do processo "Proyecto de Laboratorio en la Delegación Territorial de la Conserjería de Bienestar Social de la Junta de Castilla y León en Palencia [1984-1986]"

description: Notas de leitura do processo “Proyecto de Laboratorio en la Delegación Territorial de la Conserjería de Bienestar Social de la Junta de Castilla y León en Palencia [1984-1986]” existente no Archivo Municipal de Palencia, em Palencia.

Registo efetuado em fevereiro de 2025 no âmbito do projeto de investigação ReARQ.IB – Built Environment Knowledge for Resilient, Sustainable Communities: Understanding Everyday Modern Architecture and Urban Design in the Iberian Peninsula (1939-1985) (ERC GA949686) e publicado online em https://arquitecturaaqui.eu/es/documentacion/expedientes/58127/proyecto-de-laboratorio-en-la-delegacion-territorial-de-la-conserjeria-de-bienestar-social-de-la-junta-de-castilla-y-leon-en-palencia-1984-1986. 

Dados exportados da plataforma Arquitectura Aqui (https://arquitecturaaqui.eu), repositório do referido projeto, em janeiro de 2026.
DOI: 10.5281/zenodo.18208221
title: Notas de leitura do processo "Proyecto de Laboratorio en la Delegación Territorial de la Conserjería de Bienestar Social de la Junta de Castilla y León en Palencia [1984-1986]"

description: Notas de leitura do processo “Proyecto de Laboratorio en la Delegación Territorial de la Conserjería de Bienestar Social de la Junta de Castilla y León en Palencia [1984-1986]” existente no Archivo Municipal de Palencia, em Palencia.

Registo efetuado em fevereiro de 2025 no âmbito do projeto de investigação ReARQ.IB – Built Environment Knowledge for Resilient, Sustainable Communities: Understanding Everyday Modern Architecture and Urban Design in the Iberian Peninsula (1939-1985) (ERC GA949686) e publicado online em https://arquitecturaaqui.eu/es/documentacion/expedientes/58127/proyecto-de-laboratorio-en-la-delegacion-territorial-de-la-conserjeria-de-bienestar-social-de-la-junta-de-castilla-y-leon-en-palencia-1984-1986. 

Dados exportados da plataforma Arquitectura Aqui (https://arquitecturaaqui.eu), repositório do referido projeto, em janeiro de 2026.
DOI: 10.15468/dl.8hcksq
title: Occurrence Download

description: A dataset containing 111 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Madagascar",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Psidium cattleianum"
 ]
}

 The dataset includes 111 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014196-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3kw8tv
title: Occurrence Download

description: A dataset containing 331 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Phyteuma nigrum)",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "Year is greater than or equal to 2010",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "CoordinateUncertaintyInMeters is less than or equal to 50",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 331 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014197-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48733/ifjpan/ci9fq6
title: Selective reflection of light in glassforming ternary liquid crystalline mixtures - research data

description: The data were obtained with the differential scanning calorimetry, polarizing optical microscopy, X-ray diffraction, and broadband dielectric spectroscopy. The measurements were performed for two liquid crystalline mixtures: MIX5HFHH6 (MHPOBC:3F5HPhF6:3F5HPhH6 molar ratio 0.5:0.25:0.25) and MIX6HFHH6 (MHPOBC:3F6HPhF6:3F6HPhH6 molar ratio 0.5:0.25:0.25). The dataset was obtained as a part of the project “Research and characterization of the smectic glasses of selected liquid crystalline mixtures” 2023/07/X/ST3/00182 (MINIATURA 7), financed by the National Science Centre, Poland.
DOI: 10.15468/dl.nshk35
title: Occurrence Download

description: A dataset containing 1149860 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rumex acetosa"
 ]
}

 The dataset includes 1149860 records from 3573 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014111-260108223611665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57745/1fodeq
title: Raw-data-AChE-activity-supra-lethal-Hippocampus-D7-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/6iazxd
title: Raw-data-AChE-activity-sub-lethal-Piriform-cortex-amygdala-BiomedPharmaco-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/dfty1m
title: Raw-data-AChE-activity-sub-lethal-Motor-cortex-BiomedPharmaco-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/ocm7wc
title: Raw-data-AChE-activity-sub-lethal-Somatosensory-cortex-BiomedPharmaco-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/pnadrs
title: Raw-data-AChE-activity-supra-lethal-Hippocampus-D3-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/ps23dl
title: Raw-data-AChE-activity-sub-lethal-Spinal-cord-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/qvstmq
title: Raw-data-AChE-activity-supra-lethal-Somatosensory-cortex-D3-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/rpmsgg
title: Raw-data-AChE-activity-supra-lethal-Somatosensory-cortex-D1-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/svffpi
title: Raw-data-AChE-activity-sub-lethal-Diaphragm-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/tyrmpl
title: Raw-data-AChE-activity-supra-lethal-Somatosensory-cortex-D7-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/wdzu7b
title: Raw-data-AChE-activity-sub-lethal-Blood-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/wub0cg
title: Raw-data-AChE-activity supra-lethal-Hippocampus-D1-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.57745/xswoqo
title: Raw-data-AChE-activity-sub-lethal-Hippocampus-BiomedPharmaco-Lepinard-et-al-2025.tab

description: :unav
DOI: 10.15468/dl.wqex5b
title: Occurrence Download

description: A dataset containing 1897 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Picea omorika (Pancic) Purk."
 ]
}

 The dataset includes 1897 records from 106 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002870-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13127/mx04_macmap_08
title: Temperature profiles from eXpandable BathyTermograph (XBT) collected in June 2023 along the MX04 transect
title: MX04_MACMAP_08

description: The MX04_MACMAP_08 datasets have been gathered during the monitoring campaigns of sea temperature in the Ligurian and Tyrrhenian Seas started in September 2021 within the MACMAP project in collaboration with ENEA and GNV S.p.A. shipping company. The data are collected using XBT probes along the Genova-Palermo track (MX04 line of the SOOP program of GOOS) using ships of opportunity. According to Simoncelli et al. (2024) a full metadata description, compliant with the most recent community standards and formats, completes the dataset.
description: The data gathered using XBT (eXpendable BathyThermograph) probes during MACMAP monitoring activities in the Tyrrhenian and Ligurian Seas between 2021 and 2024 have been first formatted and standardized according to the latest community best practices and all available metadata have been inserted. Secondly, a new automatic Quality Control (QC) procedure has been developed and a new interpolation scheme has been applied, according to 10.5194/essd-2023-525.
DOI: 10.15468/dl.dyx8ex
title: Occurrence Download

description: A dataset containing 336689165 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "Geometry POLYGON((-118.10852 20.57501,-74.73752 20.57501,-74.73752 38.63189,-118.10852 38.63189,-118.10852 20.57501))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 336689165 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011242-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13127/mx04_macmap_07
title: Temperature profiles from eXpandable BathyTermograph (XBT) collected in March 2023 along the MX04 transect
title: MX04_MACMAP_07

description: The MX04_MACMAP_07 datasets have been gathered during the monitoring campaigns of sea temperature in the Ligurian and Tyrrhenian Seas started in September 2021 within the MACMAP project in collaboration with ENEA and GNV S.p.A. shipping company. The data are collected using XBT probes along the Genova-Palermo track (MX04 line of the SOOP program of GOOS) using ships of opportunity. According to Simoncelli et al. (2024) a full metadata description, compliant with the most recent community standards and formats, completes the dataset.
description: The data gathered using XBT (eXpendable BathyThermograph) probes during MACMAP monitoring activities in the Tyrrhenian and Ligurian Seas between 2021 and 2024 have been first formatted and standardized according to the latest community best practices and all available metadata have been inserted. Secondly, a new automatic Quality Control (QC) procedure has been developed and a new interpolation scheme has been applied, according to 10.5194/essd-2023-525.
DOI: 10.15468/dl.z6n29j
title: Occurrence Download

description: A dataset containing 131 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Primula moupinensis Franch."
 ]
}

 The dataset includes 131 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011261-250415084134356/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13127/mx04_macmap_06
title: Temperature profiles from eXpandable BathyTermograph (XBT) collected in December 2022 along the MX04 transect
title: MX04_MACMAP_06

description: The MX04_MACMAP_06 datasets have been gathered during the monitoring campaigns of sea temperature in the Ligurian and Tyrrhenian Seas started in September 2021 within the MACMAP project in collaboration with ENEA and GNV S.p.A. shipping company. The data are collected using XBT probes along the Genova-Palermo track (MX04 line of the SOOP program of GOOS) using ships of opportunity. According to Simoncelli et al. (2024) a full metadata description, compliant with the most recent community standards and formats, completes the dataset.
description: The data gathered using XBT (eXpendable BathyThermograph) probes during MACMAP monitoring activities in the Tyrrhenian and Ligurian Seas between 2021 and 2024 have been first formatted and standardized according to the latest community best practices and all available metadata have been inserted. Secondly, a new automatic Quality Control (QC) procedure has been developed and a new interpolation scheme has been applied, according to 10.5194/essd-2023-525.