cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1136008
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v6
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v1
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v7
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136017.v8
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v2
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v9
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v3
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v10
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v4
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136008.v5
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v11
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v6
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v12
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136017.v13
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v7
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v14
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136017.v15
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v8
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v16
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1135993
title: Rat hippocampal LFP, eyelid EMG, and stimulus timstamps (PLOS ONE Data)

description: The original raw data of the experiment in the Plos One paper; Keita Tokuda, Michimasa Nishikawa, Shigenori Kawahara, "Hippocampal state-dependent behavioral reflex to an identical sensory input in rats," <em>PLOS ONE</em>, (accepted). The data contains folders corresponding each rat:t1, t2, t3, t5, t6.<br>Each of those folders contains folders corresponding 12 sessions.<br>Each folder contains the files in Neuralynx file format, as below;<br>---------------------------- EMG.Ncs<br>Events.Nev<br>LogFile.txt<br>hippo.Ncs ---------------------------- The file "hippo.ncs" contains all the data from hippocampus acquired during the experimet. The file "EMG.ncs" contains all the data of eyelid electromyography acquired during the experiment.<br>One can refer to the Event.Nev file to know the time points of the task stimuli.<br>One can either visualize and convert the neuralynx files by downloading softwares from Neuralynx web cite.<br>http://neuralynx.com/research_software/file_converters_and_utilities/
DOI: 10.6084/m9.figshare.1136008.v9
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1136017.v17
title: Low-frequency sound affects active micromechanics in the human inner ear

description: Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (&lt;250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea, which are driven very inadequately at low frequencies. To assess the impact of low-frequency sound, we exploited a by-product of the active amplification of sound outer hair cells perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, low-frequency sounds significantly affects outer hair cells: A 90 s, 80 dB(A) low-frequency sound induced slow, concordant and positively correlated frequency- and level oscillations of spontaneous otoacoustic emissions which lasted for about two minutes after low-frequency sound offset. Low-frequency sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.
DOI: 10.6084/m9.figshare.1136008.v10
title: Two new cyclic dipeptides from <i>Rhinocladiella</i> sp. lgt-3, a fungal endophyte isolated from <i>Tripterygiun wilfordii</i> Hook

description: Two new cyclic dipeptides, rhinocladin A (<b>1</b>) and rhinocladin B (<b>2</b>), were isolated from a fungal endophyte (<i>Rhinocladiella</i> sp. lgt-3) of <i>Tripterygiun wilfordii</i> Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of <b>1</b> and <b>2</b> was also evaluated.
DOI: 10.6084/m9.figshare.1135993.v1
title: Hippocampal state-dependent behavioral reflex to an identical sensory input in rats

description: We examined the rat hippocampal local field potentials to monitor brain states during a conditional discrimination task in eyeblink conditioning.