cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7925/drs1.duchas_4502408
title: Pisreoga

description: Story collected by Paddy Delaney, a student at Mainistir Mhuigheó (B) school (Mayo Abbey, Co. Mayo) from informant Walter Hughes.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Padraig Ó Cuinn.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.6084/m9.figshare.7928129.v1
title: gVCF_NA19310

description: 1000 Genomes gVCF mapped to hs37d5 for NA19310. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928138.v1
title: Anammox_iTag

description: read files for 16S rRNA analysis of anammox reactor microbial community
DOI: 10.6084/m9.figshare.7928117
title: gVCF_NA19309

description: 1000 Genomes gVCF mapped to hs37d5 for NA19309. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928120.v1
title: gVCF_HG03823

description: 1000 Genomes gVCF mapped to hs37d5 for HG03823. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928111
title: gVCF_HG03821

description: 1000 Genomes gVCF mapped to hs37d5 for HG03821. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928114
title: gVCF_HG02155

description: 1000 Genomes gVCF mapped to hs37d5 for HG02155. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928117.v1
title: gVCF_NA19309

description: 1000 Genomes gVCF mapped to hs37d5 for NA19309. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928105
title: gVCF_NA19308

description: 1000 Genomes gVCF mapped to hs37d5 for NA19308. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928108
title: gVCF_HG02154

description: 1000 Genomes gVCF mapped to hs37d5 for HG02154. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928111.v1
title: gVCF_HG03821

description: 1000 Genomes gVCF mapped to hs37d5 for HG03821. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928114.v1
title: gVCF_HG02155

description: 1000 Genomes gVCF mapped to hs37d5 for HG02155. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928096
title: gVCF_HG02153

description: 1000 Genomes gVCF mapped to hs37d5 for HG02153. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928105.v1
title: gVCF_NA19308

description: 1000 Genomes gVCF mapped to hs37d5 for NA19308. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928090
title: gVCF_NA19307

description: 1000 Genomes gVCF mapped to hs37d5 for NA19307. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928093
title: gVCF_HG02152

description: 1000 Genomes gVCF mapped to hs37d5 for HG02152. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928102
title: gVCF_HG03817

description: 1000 Genomes gVCF mapped to hs37d5 for HG03817. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928108.v1
title: gVCF_HG02154

description: 1000 Genomes gVCF mapped to hs37d5 for HG02154. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928087
title: gVCF_HG03815

description: 1000 Genomes gVCF mapped to hs37d5 for HG03815. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928096.v1
title: gVCF_HG02153

description: 1000 Genomes gVCF mapped to hs37d5 for HG02153. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928102.v1
title: gVCF_HG03817

description: 1000 Genomes gVCF mapped to hs37d5 for HG03817. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928078
title: gVCF_NA19257

description: 1000 Genomes gVCF mapped to hs37d5 for NA19257. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928081
title: gVCF_HG02151

description: 1000 Genomes gVCF mapped to hs37d5 for HG02151. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928090.v1
title: gVCF_NA19307

description: 1000 Genomes gVCF mapped to hs37d5 for NA19307. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928093.v1
title: gVCF_HG02152

description: 1000 Genomes gVCF mapped to hs37d5 for HG02152. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928078.v1
title: gVCF_NA19257

description: 1000 Genomes gVCF mapped to hs37d5 for NA19257. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928087.v1
title: gVCF_HG03815

description: 1000 Genomes gVCF mapped to hs37d5 for HG03815. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928069
title: gVCF_HG02150

description: 1000 Genomes gVCF mapped to hs37d5 for HG02150. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928072
title: gVCF_NA19256

description: 1000 Genomes gVCF mapped to hs37d5 for NA19256. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928075
title: gVCF_HG03814

description: 1000 Genomes gVCF mapped to hs37d5 for HG03814. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928063
title: gVCF_NA19248

description: 1000 Genomes gVCF mapped to hs37d5 for NA19248. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928066
title: gVCF_HG03812

description: 1000 Genomes gVCF mapped to hs37d5 for HG03812. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928072.v1
title: gVCF_NA19256

description: 1000 Genomes gVCF mapped to hs37d5 for NA19256. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928075.v1
title: gVCF_HG03814

description: 1000 Genomes gVCF mapped to hs37d5 for HG03814. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928081.v1
title: gVCF_HG02151

description: 1000 Genomes gVCF mapped to hs37d5 for HG02151. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928057
title: gVCF_HG03809

description: 1000 Genomes gVCF mapped to hs37d5 for HG03809. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928060
title: gVCF_HG02147

description: 1000 Genomes gVCF mapped to hs37d5 for HG02147. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928066.v1
title: gVCF_HG03812

description: 1000 Genomes gVCF mapped to hs37d5 for HG03812. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928069.v1
title: gVCF_HG02150

description: 1000 Genomes gVCF mapped to hs37d5 for HG02150. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928057.v1
title: gVCF_HG03809

description: 1000 Genomes gVCF mapped to hs37d5 for HG03809. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928060.v1
title: gVCF_HG02147

description: 1000 Genomes gVCF mapped to hs37d5 for HG02147. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928051
title: gVCF_NA19247

description: 1000 Genomes gVCF mapped to hs37d5 for NA19247. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928063.v1
title: gVCF_NA19248

description: 1000 Genomes gVCF mapped to hs37d5 for NA19248. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928039
title: gVCF_HG02144

description: 1000 Genomes gVCF mapped to hs37d5 for HG02144. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928042
title: gVCF_NA19240

description: 1000 Genomes gVCF mapped to hs37d5 for NA19240. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928045
title: gVCF_HG03808

description: 1000 Genomes gVCF mapped to hs37d5 for HG03808. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928054
title: gVCF_HG02146

description: 1000 Genomes gVCF mapped to hs37d5 for HG02146. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928042.v1
title: gVCF_NA19240

description: 1000 Genomes gVCF mapped to hs37d5 for NA19240. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928045.v1
title: gVCF_HG03808

description: 1000 Genomes gVCF mapped to hs37d5 for HG03808. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928051.v1
title: gVCF_NA19247

description: 1000 Genomes gVCF mapped to hs37d5 for NA19247. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928054.v1
title: gVCF_HG02146

description: 1000 Genomes gVCF mapped to hs37d5 for HG02146. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928012
title: gVCF_HG03805

description: 1000 Genomes gVCF mapped to hs37d5 for HG03805. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7928039.v1
title: gVCF_HG02144

description: 1000 Genomes gVCF mapped to hs37d5 for HG02144. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7927931
title: gVCF_HG02143

description: 1000 Genomes gVCF mapped to hs37d5 for HG02143. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7927958
title: DNA methylation and functional characterization of the XIST gene during <i>in vitro</i> early embryo development in cattle

description: XIST, in association with the shorter ncRNA RepA, are essential for the initiation of X chromosome inactivation (XCI) in mice. The molecular mechanisms controlling XIST and RepA expression are well characterized in that specie. However, little is known in livestock. We aimed to characterize the DNA methylation status along the 5’ portion of XIST and to characterize its transcriptional profile during early development in cattle. Three genomic regions of XIST named here as promoter, RepA and DMR1 had their DNA methylation status characterized in gametes and embryos. Expression profile of XIST was evaluated, including sense and antisense transcription. Oocytes showed higher levels of methylation than spermatozoa that was demethylated. DMR1 was hypermethylated throughout oogenesis. At the 8–16-cell embryo stage DMR1 was completed demethylated. Interestingly, RepA gain methylation during oocyte maturation and was demethylated at the blastocyst stage, later than DMR1. These results suggest that DMR1 and RepA are transient differentially methylated regions in cattle. XIST RNA was detected in matured oocytes and in single cells from the 2-cell to the morula stage, confirming the presence of maternal and embryonic transcripts. Sense and antisense transcripts were detected along the XIST in blastocyst. <i>In silico</i> analysis identified 63 novel transcript candidates at bovine XIST locus from both the plus and minus strands. Taking together these results improve our understanding of the molecular mechanisms involved in XCI initiation in cattle. This information may be useful for the improvement of assisted reproductive technologies in livestock considering that <i>in vitro</i> conditions may impair epigenetic reprogramming.
DOI: 10.6084/m9.figshare.7927973
title: gVCF_NA19239

description: 1000 Genomes gVCF mapped to hs37d5 for NA19239. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7927931.v1
title: gVCF_HG02143

description: 1000 Genomes gVCF mapped to hs37d5 for HG02143. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7927973.v1
title: gVCF_NA19239

description: 1000 Genomes gVCF mapped to hs37d5 for NA19239. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7927958.v1
title: DNA methylation and functional characterization of the XIST gene during in vitro early embryo development in cattle

description: XIST, in association with the shorter ncRNA RepA, are essential for the initiation of X chromosome inactivation (XCI) in mice. The molecular mechanisms controlling XIST and RepA expression are well characterized in that specie. However, little is known in livestock. We aimed to characterize the DNA methylation status along the 5ʹ portion of XIST and to characterize its transcriptional profile during early development in cattle. Three genomic regions of XIST named here as promoter, RepA and DMR1 had their DNA methylation status characterized in gametes and embryos. Expression profile of XIST was evaluated, including sense and antisense transcription. Oocytes showed higher levels of methylation than spermatozoa that was demethylated. DMR1 was hypermethylated throughout oogenesis. At the 8-16-cell embryo stage DMR1 was completed demethylated. Interestingly, RepA gain methylation during oocyte maturation and was demethylated at the blastocyst stage, later than DMR1. These results suggest that DMR1 and RepA are transient differentially methylated regions in cattle. XIST RNA was detected in matured oocytes and in single cells from the 2-cell to the morula stage, confirming the presence of maternal and embryonic transcripts. Sense and antisense transcripts were detected along the XIST in blastocyst. <i>In silico</i> analysis identified 63 novel transcript candidates at bovine XIST locus from both the plus and minus strands. Taking together these results improve our understanding of the molecular mechanisms involved in XCI initiation in cattle. This information may be useful for the improvement of assisted reproductive technologies in livestock considering that <i>in vitro</i> conditions may impair epigenetic reprogramming.
DOI: 10.6084/m9.figshare.7927958.v2
title: DNA methylation and functional characterization of the XIST gene during <i>in vitro</i> early embryo development in cattle

description: XIST, in association with the shorter ncRNA RepA, are essential for the initiation of X chromosome inactivation (XCI) in mice. The molecular mechanisms controlling XIST and RepA expression are well characterized in that specie. However, little is known in livestock. We aimed to characterize the DNA methylation status along the 5’ portion of XIST and to characterize its transcriptional profile during early development in cattle. Three genomic regions of XIST named here as promoter, RepA and DMR1 had their DNA methylation status characterized in gametes and embryos. Expression profile of XIST was evaluated, including sense and antisense transcription. Oocytes showed higher levels of methylation than spermatozoa that was demethylated. DMR1 was hypermethylated throughout oogenesis. At the 8–16-cell embryo stage DMR1 was completed demethylated. Interestingly, RepA gain methylation during oocyte maturation and was demethylated at the blastocyst stage, later than DMR1. These results suggest that DMR1 and RepA are transient differentially methylated regions in cattle. XIST RNA was detected in matured oocytes and in single cells from the 2-cell to the morula stage, confirming the presence of maternal and embryonic transcripts. Sense and antisense transcripts were detected along the XIST in blastocyst. <i>In silico</i> analysis identified 63 novel transcript candidates at bovine XIST locus from both the plus and minus strands. Taking together these results improve our understanding of the molecular mechanisms involved in XCI initiation in cattle. This information may be useful for the improvement of assisted reproductive technologies in livestock considering that <i>in vitro</i> conditions may impair epigenetic reprogramming.
DOI: 10.6084/m9.figshare.7927868
title: Additional file 1: of miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells

description: Table S1 List of genes positively and negatively correlated to miR-96-5p expression in the subset of TCGA HNSCC tumors carrying missense TP53 mutations by bioinformatics analyses. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.7927868.v1
title: Additional file 1: of miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells

description: Table S1 List of genes positively and negatively correlated to miR-96-5p expression in the subset of TCGA HNSCC tumors carrying missense TP53 mutations by bioinformatics analyses. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.7927844
title: Additional file 1: of Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes

description: Participants’ responses to the questionnaire. The participants (n = 284) were presented with the survey questionnaire items (Q) regarding previous history of VVC (Q1), lifetime/annual frequencies of VVC episodes (Q2-Q3), vulvovaginal signs and symptoms (Q4), known causes (Q5), choice of clinical interventions for diagnoses and treatment regimens (Q6), post-treatment outcomes (Q7-Q10) and participant demographics (Q11-Q13). A set of 2 to 12 answer choices was included per question. All answer(s) selected by each respondent are indicated (Sheet 1. Raw data). Respondents selecting other as an answer choice in Q5-Q6 provided their specified responses as listed in the corresponding spreadsheets (Sheets 2–3. Q5 others and Q6 others). (XLSX 34 kb)
DOI: 10.6084/m9.figshare.7927844.v1
title: Additional file 1: of Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes

description: Participants’ responses to the questionnaire. The participants (n = 284) were presented with the survey questionnaire items (Q) regarding previous history of VVC (Q1), lifetime/annual frequencies of VVC episodes (Q2-Q3), vulvovaginal signs and symptoms (Q4), known causes (Q5), choice of clinical interventions for diagnoses and treatment regimens (Q6), post-treatment outcomes (Q7-Q10) and participant demographics (Q11-Q13). A set of 2 to 12 answer choices was included per question. All answer(s) selected by each respondent are indicated (Sheet 1. Raw data). Respondents selecting other as an answer choice in Q5-Q6 provided their specified responses as listed in the corresponding spreadsheets (Sheets 2–3. Q5 others and Q6 others). (XLSX 34 kb)
DOI: 10.6084/m9.figshare.7927814
title: Additional file 2: of FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing

description: Table S2. Inventory of pOCC shuttle vectors available at www.addgene.org . The 52 most popular shuttle vectors were deposited to Addgene (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7927811
title: Additional file 1: of FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing

description: Table S1. Inventory of available pOCC shuttle vectors. The userâ s gene of interest can be inserted into 143 available vectors using NotI and AscI restriction cloning (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7927814.v1
title: Additional file 2: of FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing

description: Table S2. Inventory of pOCC shuttle vectors available at www.addgene.org . The 52 most popular shuttle vectors were deposited to Addgene (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7927811.v1
title: Additional file 1: of FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing

description: Table S1. Inventory of available pOCC shuttle vectors. The userâ s gene of interest can be inserted into 143 available vectors using NotI and AscI restriction cloning (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7927754
title: Additional file 1: of Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)

description: GRADE Table - First area - PK variability provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the first area of the guidelines: “Pharmacokinetic variability of beta-lactam antibiotics”. GRADE Table - Second area – PK-PD provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the second area of the guidelines: “Pharmacokinetic-Pharmacodynamic relationship of beta-lactam antibiotics”. GRADE Table - Third area – Administration of beta-lactams provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the third area of the guidelines: “Administration of beta-lactam antibiotics”. GRADE Table - Fourth area – TDM provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the fourth area of the guidelines: “Therapeutic Drug Monitoring of beta-lactam antibiotics”. Flow-charts of study seletion provides a flow chart of the selection of the relevant studies among all the studies identified by the literature search for each of the four areas of the guidelines. Supplementary method file provides the keywords used for the bibliographic search for each of the four areas of the guidelines. (ZIP 134 kb)
DOI: 10.6084/m9.figshare.7927754.v1
title: Additional file 1: of Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)

description: GRADE Table - First area - PK variability provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the first area of the guidelines: “Pharmacokinetic variability of beta-lactam antibiotics”. GRADE Table - Second area – PK-PD provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the second area of the guidelines: “Pharmacokinetic-Pharmacodynamic relationship of beta-lactam antibiotics”. GRADE Table - Third area – Administration of beta-lactams provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the third area of the guidelines: “Administration of beta-lactam antibiotics”. GRADE Table - Fourth area – TDM provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the fourth area of the guidelines: “Therapeutic Drug Monitoring of beta-lactam antibiotics”. Flow-charts of study seletion provides a flow chart of the selection of the relevant studies among all the studies identified by the literature search for each of the four areas of the guidelines. Supplementary method file provides the keywords used for the bibliographic search for each of the four areas of the guidelines. (ZIP 134 kb)