cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24289066
title: Supplementary Material for: Outcomes and Feasibility of an Occupational Care Programme (TERRA) to Support Work Ability of Rare and Advanced Cancer Patients: A Report of 7 Cases

description: Introduction: Advancements in the field of oncology are allowing patients to live longer, with enhanced quality of life (QoL). Accordingly, more patients with cancer are expressing the desire to return to work (RTW). Previous research has indicated that patients with a rare or advanced cancer can experience unique problems in the RTW process. Methods: This pilot study evaluated the outcomes and feasibility of the occupational care programme TERRA (i.e., recalibraTe lifE and woRk with and afteR cAncer) for patients with a rare or advanced cancer. Four rare cancer patients and three advanced cancer patients completed TERRA; a supportive occupational care programme consisting of five online group sessions over a two-month period. Pre- and post-intervention outcomes were collected using validated self-report questionnaires. The primary outcome was work ability. Secondary outcomes included QoL, anxiety and depression, fatigue, unmet needs, self-efficacy, readiness for RTW, work intention, work involvement, and work-life conflict. Feasibility was assessed using the RE-AIM model. Results: Changes in work ability scores were inconsistent across participants. Well-being outcomes generally improved following the intervention. Feasibility was evaluated positively by both participants and trainers. Discussion/Conclusion: A multidisciplinary approach may further improve outcomes of occupational interventions supporting rare and advanced cancer patients. An effectiveness study to evaluate the outcomes and feasibility of the programme is deemed necessary.
DOI: 10.6084/m9.figshare.24289066.v1
title: Supplementary Material for: Outcomes and Feasibility of an Occupational Care Programme (TERRA) to Support Work Ability of Rare and Advanced Cancer Patients: A Report of 7 Cases

description: Introduction: Advancements in the field of oncology are allowing patients to live longer, with enhanced quality of life (QoL). Accordingly, more patients with cancer are expressing the desire to return to work (RTW). Previous research has indicated that patients with a rare or advanced cancer can experience unique problems in the RTW process. Methods: This pilot study evaluated the outcomes and feasibility of the occupational care programme TERRA (i.e., recalibraTe lifE and woRk with and afteR cAncer) for patients with a rare or advanced cancer. Four rare cancer patients and three advanced cancer patients completed TERRA; a supportive occupational care programme consisting of five online group sessions over a two-month period. Pre- and post-intervention outcomes were collected using validated self-report questionnaires. The primary outcome was work ability. Secondary outcomes included QoL, anxiety and depression, fatigue, unmet needs, self-efficacy, readiness for RTW, work intention, work involvement, and work-life conflict. Feasibility was assessed using the RE-AIM model. Results: Changes in work ability scores were inconsistent across participants. Well-being outcomes generally improved following the intervention. Feasibility was evaluated positively by both participants and trainers. Discussion/Conclusion: A multidisciplinary approach may further improve outcomes of occupational interventions supporting rare and advanced cancer patients. An effectiveness study to evaluate the outcomes and feasibility of the programme is deemed necessary.
DOI: 10.6084/m9.figshare.22290775.v1
title: SOPHIE: Spitzoid WSI dataset with clinical data

description: WSIs in .tif are grouped into three categories according to the histopathological diagnosis and each file is named according to the following format: Spitz Nevus (SN_00XX), Spitzoid Melanoma (SM_00XX), and Spitzoid Tumor of Unknown Malignant Potential (STUMP_00XX). In the SM group, there are two cases with more than one WSI. SM_0015 ("SM_0015A" and "SM_0015B") are two images of different regions of the same tumor. In SM_0016, "SM_0016A" is the primary tumor, while "SM_0016B" and "SM_0016C" are the lymph node metastasis of the same patient. Additionaly the is a excell file with the corresponding clinical data for each case.
DOI: 10.6084/m9.figshare.22290775
title: SOPHIE: Spitzoid WSI dataset with clinical data

description: WSIs in .tif are grouped into three categories according to the histopathological diagnosis and each file is named according to the following format: Spitz Nevus (SN_00XX), Spitzoid Melanoma (SM_00XX), and Spitzoid Tumor of Unknown Malignant Potential (STUMP_00XX). In the SM group, there are two cases with more than one WSI. SM_0015 ("SM_0015A" and "SM_0015B") are two images of different regions of the same tumor. In SM_0016, "SM_0016A" is the primary tumor, while "SM_0016B" and "SM_0016C" are the lymph node metastasis of the same patient. Additionaly the is a excell file with the corresponding clinical data for each case.
DOI: 10.6084/m9.figshare.24289084
title: Supplementary Material for: Outcomes and Feasibility of an Occupational Care Programme (TERRA) to Support Work Ability of Rare and Advanced Cancer Patients: A Report of 7 Cases

description: Introduction: Advancements in the field of oncology are allowing patients to live longer, with enhanced quality of life (QoL). Accordingly, more patients with cancer are expressing the desire to return to work (RTW). Previous research has indicated that patients with a rare or advanced cancer can experience unique problems in the RTW process. Methods: This pilot study evaluated the outcomes and feasibility of the occupational care programme TERRA (i.e., recalibraTe lifE and woRk with and afteR cAncer) for patients with a rare or advanced cancer. Four rare cancer patients and three advanced cancer patients completed TERRA; a supportive occupational care programme consisting of five online group sessions over a two-month period. Pre- and post-intervention outcomes were collected using validated self-report questionnaires. The primary outcome was work ability. Secondary outcomes included QoL, anxiety and depression, fatigue, unmet needs, self-efficacy, readiness for RTW, work intention, work involvement, and work-life conflict. Feasibility was assessed using the RE-AIM model. Results: Changes in work ability scores were inconsistent across participants. Well-being outcomes generally improved following the intervention. Feasibility was evaluated positively by both participants and trainers. Discussion/Conclusion: A multidisciplinary approach may further improve outcomes of occupational interventions supporting rare and advanced cancer patients. An effectiveness study to evaluate the outcomes and feasibility of the programme is deemed necessary.
DOI: 10.6084/m9.figshare.24289084.v1
title: Supplementary Material for: Outcomes and Feasibility of an Occupational Care Programme (TERRA) to Support Work Ability of Rare and Advanced Cancer Patients: A Report of 7 Cases

description: Introduction: Advancements in the field of oncology are allowing patients to live longer, with enhanced quality of life (QoL). Accordingly, more patients with cancer are expressing the desire to return to work (RTW). Previous research has indicated that patients with a rare or advanced cancer can experience unique problems in the RTW process. Methods: This pilot study evaluated the outcomes and feasibility of the occupational care programme TERRA (i.e., recalibraTe lifE and woRk with and afteR cAncer) for patients with a rare or advanced cancer. Four rare cancer patients and three advanced cancer patients completed TERRA; a supportive occupational care programme consisting of five online group sessions over a two-month period. Pre- and post-intervention outcomes were collected using validated self-report questionnaires. The primary outcome was work ability. Secondary outcomes included QoL, anxiety and depression, fatigue, unmet needs, self-efficacy, readiness for RTW, work intention, work involvement, and work-life conflict. Feasibility was assessed using the RE-AIM model. Results: Changes in work ability scores were inconsistent across participants. Well-being outcomes generally improved following the intervention. Feasibility was evaluated positively by both participants and trainers. Discussion/Conclusion: A multidisciplinary approach may further improve outcomes of occupational interventions supporting rare and advanced cancer patients. An effectiveness study to evaluate the outcomes and feasibility of the programme is deemed necessary.
DOI: 10.5517/ccdc.csd.cc2d0j76
title: CCDC 2205037: Experimental Crystal Structure Determination

description: Related Article: Yujiao Hou, Peilin Han, Like Zhang, Hao Li, Zhihong Xu|2022|Inorg.Chem.Front.|10|148|doi:10.1039/D2QI01922A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.24289114
title: Supplementary Material for: Comprehensive analysis of the relationship between cuproptosis-related gene GCSH and prognosis, tumor microenvironment infiltration, and therapy response in endometrial cancer

description: Background: Cuproptosis, a novel form of cell death regulated by protein lipoylation and implicated in mitochondrial metabolism. However, the impact of the cuproptosis-related gene γ-glutamylcysteine synthetase (GCSH) on endometrial cancer (EC) prognosis, tumor immune microenvironment, and therapeutic response remains to be further researched. Methods: The differential expression of GCSH between endometrial cancer and normal tissues was analyzed using multiple public databases. Additionally, cancer and adjacent tissues were prospectively collected from 17 EC patients, and immunohistochemical analysis was performed to further investigate GCSH expression differences. The relationship between GCSH and the prognosis and clinicopathological characteristics of EC patients was evaluated, and a nomogram was constructed to predict patient survival based on GCSH expression. Then, Gene set variation analysis (GSVA) was utilized to explore the potential biological functions of GCSH in EC. The impact of GCSH on the tumor microenvironment (TME) was estimated. Finally, the effect of GCSH on the response to immunotherapy and chemotherapeutic drugs in EC was investigated. Results: The expression of GCSH was significantly upregulated in EC. High GCSH expression was associated with poor prognosis in EC patients. Enrichment analysis showed that high GCSH was associated with immune suppression. Furthermore, high GCSH was found to be associated with a non-inflamed TME, leading to decreased infiltration levels of immune cells. Finally, it was observed that patients with high GCSH were insensitive to both immunotherapy and chemotherapeutic drugs. Conclusion: This study revealed the role of GCSH in TME, response to therapy, and clinical prognosis in EC, which provided novel insights for the therapeutic application in EC.
DOI: 10.6084/m9.figshare.24289114.v1
title: Supplementary Material for: Comprehensive analysis of the relationship between cuproptosis-related gene GCSH and prognosis, tumor microenvironment infiltration, and therapy response in endometrial cancer

description: Background: Cuproptosis, a novel form of cell death regulated by protein lipoylation and implicated in mitochondrial metabolism. However, the impact of the cuproptosis-related gene γ-glutamylcysteine synthetase (GCSH) on endometrial cancer (EC) prognosis, tumor immune microenvironment, and therapeutic response remains to be further researched. Methods: The differential expression of GCSH between endometrial cancer and normal tissues was analyzed using multiple public databases. Additionally, cancer and adjacent tissues were prospectively collected from 17 EC patients, and immunohistochemical analysis was performed to further investigate GCSH expression differences. The relationship between GCSH and the prognosis and clinicopathological characteristics of EC patients was evaluated, and a nomogram was constructed to predict patient survival based on GCSH expression. Then, Gene set variation analysis (GSVA) was utilized to explore the potential biological functions of GCSH in EC. The impact of GCSH on the tumor microenvironment (TME) was estimated. Finally, the effect of GCSH on the response to immunotherapy and chemotherapeutic drugs in EC was investigated. Results: The expression of GCSH was significantly upregulated in EC. High GCSH expression was associated with poor prognosis in EC patients. Enrichment analysis showed that high GCSH was associated with immune suppression. Furthermore, high GCSH was found to be associated with a non-inflamed TME, leading to decreased infiltration levels of immune cells. Finally, it was observed that patients with high GCSH were insensitive to both immunotherapy and chemotherapeutic drugs. Conclusion: This study revealed the role of GCSH in TME, response to therapy, and clinical prognosis in EC, which provided novel insights for the therapeutic application in EC.
DOI: 10.11583/dtu.23365280
title: Kortfisk - Anthropogenic activities at-sea (not fishing)

description: Geopackage - Open in e.g., qGIS or R with sf This file compiles anthropegenic activities at sea in Danish waters based on data retrieved from various sources, including HELCOM https://helcom.fi, OSPAR https://www.ospar.org, and (mostly) the Danish Maritime Authorities through their webportal https://havplan.dk This file is used in the KORTFISK project (DTU Aqua) to map the overlap between fishing and other anthropogenic activities at sea in Danish waters. All sources of data are referenced in the file.
DOI: 10.11583/dtu.23365280.v1
title: Kortfisk - Anthropogenic activities at-sea (not fishing)

description: Geopackage - Open in e.g., qGIS or R with sf This file compiles anthropegenic activities at sea in Danish waters based on data retrieved from various sources, including HELCOM https://helcom.fi, OSPAR https://www.ospar.org, and (mostly) the Danish Maritime Authorities through their webportal https://havplan.dk This file is used in the KORTFISK project (DTU Aqua) to map the overlap between fishing and other anthropogenic activities at sea in Danish waters. All sources of data are referenced in the file.
DOI: 10.57801/d8vk-qy91
title: The core tendencies underlying individual differences in prosocial behavior - WP1

description: Prior research has shown that certain personality traits account for individual differences in prosocial behaviour in certain situations. To provide a systematic understanding of these findings, Thielmann, Spadaro, and Balliet (2020) proposed an affordance-based framework providing clear hypotheses about which personality traits should predict prosocial behaviour under which circumstances. The current project aims to provide a conclusive test of this framework by specifically testing the framework’s key proposition that four broad trait classes can be identified, each of which predicts prosocial behaviour in the presence of a different situational affordance. To this end, we use data from the Prosocial Personality Project, a large-scale longitudinal study including various measures of personality and prosocial behaviour. We base our (pre-registered) analyses on a sample of N = 2649 participants who completed one of six economic games measuring incentivized prosocial behaviour in the presence of different situational affordances. We apply bifactor modelling to extract the shared variance among traits reflecting the same dispositional class and will predict prosocial behaviour using these latent “core tendencies”.
DOI: 10.6084/m9.figshare.24289141
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.6084/m9.figshare.24289141.v1
title: Supplementary Material for: Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock

description: Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice predisposes animals to cartilage injury and OA. Methods: The role of miR-195/497 cluster during OA progression was verified by mouse OA model with intraarticular injection of Agomir and Antagomir. We performed micro-CT analysis, Osteoarthritis Research Society International scores, and histological analysis in mouse knee joints. RNA sequencing was performed on the mouse cartilage cell line to explore the molecular mechanism of the miR-195/497 cluster and proteins in signaling pathway were evaluated using western blot. Senescence associated phenotypes were detected by western blot, senescence β-galactosidase Staining, and immunofluorescence. Results: This study demonstrated that miR-195/497-5p expression is disrupted in OA with senescent chondrocytes. In addition, miR-195/497-5p influenced the circadian rhythm of mice chondrocytes by modulating the expression of the Per2 protein, resulting in the gradual degradation of articular cartilage. We found that the miR-195/497 cluster targets DUSP3 expression. The deletion of the miR-195/497 cluster increased the level of DUSP3 expression and decreased the levels of phosphorylated ERK 1/2 and CREB. Per2 transcription is up-regulated by stimulating CREB and ERK1/2 phosphorylation. Conclusion: Our findings identify a regulatory mechanism connecting chondrocyte miR-195/497-5p to cartilage maintenance and repair and imply that circadian rhythm disturbances affected by miR-195/497-5p are risk factors for age-related joint diseases such as OA
DOI: 10.57801/m0st-x004
title: Freiburg Cohort Study
title: Freiburger Kohortenstudie

description: The aim of this study is to investigate, via official data, the emergence and evolution of crime, judicial reactions towards crime, and criminal careers. The Freiburg Cohort Study is a long-term project, which, due to its specific cohort design and its extensive period of evaluation, is unique in Germany. The following issues are of central im­por­tance to the study: Which age-dependent courses and dependencies can be observed, based on officially regis­tered crime? To what extent does the fact that one has been entered into official records at an earlier period of life – especially in childhood – determine conflict with the law at a later period? To what extent is the emergence and development of officially registered crime subordinate to a change in society? To what extent are judicial sanc­tions influenced by the type of crime committed and/or biographical factors, and to what extent are such sanctions dependent on social changes? To what extent does law enforcement intervention influence the development of delinquency?
DOI: 10.5281/zenodo.8430855
title: Topographic Wetness Index derived for Madagascar

description: The Topographic Wetness Index (TWI) is a proxy for soil moisture that can be derived from Digital Elevation Models (DEMs). Previously, TWI has been linked to patterns of plant species richness (Sørensen <em>et al</em>., 2006) and biomass (Xu <em>et al.</em>, 2015). TWI also represents the influence of topography, with catenary variation (Sørensen <em>et al</em>., 2006) and other soil properties significant to plants such as the distribution of organic matter (Pei et al., 2010) and soil carbon (Sumfleth and Duttmann, 2008). TWI is a physically-based model of catchment parameters derived from slope that calculates water supply from the contributing hillslope by routing it as drainage down the channel network through all cells in a DEM (Beven and Kirkby, 1979). The TWI quantifies the balance between water accumulation and drainage at a local catchment scale, using the following equation: <em>TWI = ln(upslope area / tan(slope))</em>.
DOI: 10.5281/zenodo.8430854
title: Topographic Wetness Index derived for Madagascar

description: The Topographic Wetness Index (TWI) is a proxy for soil moisture that can be derived from Digital Elevation Models (DEMs). Previously, TWI has been linked to patterns of plant species richness (Sørensen <em>et al</em>., 2006) and biomass (Xu <em>et al.</em>, 2015). TWI also represents the influence of topography, with catenary variation (Sørensen <em>et al</em>., 2006) and other soil properties significant to plants such as the distribution of organic matter (Pei et al., 2010) and soil carbon (Sumfleth and Duttmann, 2008). TWI is a physically-based model of catchment parameters derived from slope that calculates water supply from the contributing hillslope by routing it as drainage down the channel network through all cells in a DEM (Beven and Kirkby, 1979). The TWI quantifies the balance between water accumulation and drainage at a local catchment scale, using the following equation: <em>TWI = ln(upslope area / tan(slope))</em>.
DOI: 10.57801/5e5w-yp36
title: Virtual Reality Burglary and Sex Offender Project (VRBSOP)

description: will be added with further progress of the project