cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8988248.v1
title: The natural history of pregnancies with prenatal diagnosis of Trisomy 18 or Trisomy 13: Retrospective cases of a 23-year experience in a Brazilian public hospital

description: Abstract Trisomy 18 (T18) and trisomy 13 (T13) are polymalformative syndromes associated with a high rate of spontaneous abortions, intrauterine death, and short postnatal life. This study describes the overall outcome in a country where the therapeutic interruption of pregnancy is not available. The medical records of women with prenatal diagnosis of full trisomy of T13 or T18 between October 1994 and October 2017 were analyzed in order to describe their natural outcomes. Thirteen cases of T13 and 29 cases of T18 were included. The miscarriage rate was 9% for T18 and no cases for T13. Intrauterine fetal death occurred in 46% and 52% of cases for T13 and T18, respectively. The rate of live births for T13 was 54%, and the median survival was one day (95% CI -33.55 - 90.40) and 71% died in the first 24 hours of life. The rate of live births for T18 was 37% and the median survival was two days (95% CI -1.89 - 13.17); 90% of the affected babies died within first week of life. For the affected babies reaching the first year of life and for those who lived longer, multiple invasive and expensive procedures were required, without success in prolonging life beyond 180 days. This large series provides information for professionals and women regarding the natural histories of T13 and T18. Results of this study are consistent with those referenced in the literature, emphasizing the need of structured protocols and guidelines aiming early T13 and T18 diagnosis, prenatal care, gestation/parents follow-up, and counseling processes. For those couples with earlier diagnosis, a better follow-up and counseling during the prenatal care lead to the option for a support or palliative management of the newborn. Finally, when the counseling process is appropriate, it becomes easier to take decisions respecting the parent’s autonomy and to look for better outcomes for both, the mother and the fetus.
DOI: 10.6084/m9.figshare.8988254.v1
title: Impact of Prosthesis-Patient Mismatch on 1-Year Outcomes after Transcatheter Aortic Valve Implantation: Meta-analysis of 71,106 Patients

description: Abstract Objectives: This study sought to evaluate the impact of prosthesis-patient mismatch (PPM) on the risk of early-term mortality after transcatheter aortic valve implantation (TAVI). Methods: Databases (Medical Literature Analysis and Retrieval System Online [MEDLINE], Excerpta Medica dataBASE [EMBASE], Cochrane Controlled Trials Register [CENTRAL/CCTR], ClinicalTrials.gov, Scientific Electronic Library Online [SciELO], Latin American and Caribbean Literature on Health Sciences [LILACS], and Google Scholar) were searched for studies published until February 2019. PPM after TAVI was defined as moderate if the indexed effective orifice area (iEOA) was between 0.85 cm2/m2 and 0.65 cm2/m2 and as severe if iEOA ≤ 0.65 cm2/m2. Results: The search yielded 1,092 studies for inclusion. Of these, 18 articles were analyzed, and their data extracted. The total number of patients included who underwent TAVI was 71,106. The incidence of PPM after TAVI was 36.3% (25,846 with PPM and 45,260 without PPM). One-year mortality was not increased in patients with any PPM (odds ratio [OR] 1.021, 95% confidence interval [CI] 0.979-1.065, P=0.338) neither in those with moderate PPM (OR 0.980, 95% CI 0.933-1.029, P=0.423). Severe PPM was separately associated with high risk (OR 1.109, 95% CI 1.041-1.181, P=0.001). Conclusion: The presence of severe PPM after TAVI increased early-term mortality. Although moderate PPM seemed harmless, the findings of this study cannot not rule out the possibility of it being detrimental, since there are other registries that did not address this issue yet.
DOI: 10.6084/m9.figshare.8988242
title: Analysis of real options applied in the diversification of rural production in Paraná state

description: Abstract The objective of this paper is to analyze the contribution of the use of the Real Options Theory (TOR) in the investments analysis of the diversification of rural production in Paraná state (Brazil). It is an exploratory research, with a technical documental procedure, of quantitative character, using primary and secondary sources, in cross-section and statistical analysis of a case study on the analysis of the financial viability and the distribution of probabilities by TOR in an investment project of diversification in agricultural production. The cash flow was based on data from suppliers and information collected on the Secretariat of Agriculture of Paraná State (Seab) website, in relation to coffee, cassava, corn, soybean and wheat crops. The analysis consisted in calculating the present value using traditional investment analysis methods such as NPV, TIR and Payback, and the real options through the binomial tree for comparability. The results show that the Real Options Theory is a more accurate method to calculate the present value in projects of diversification of rural production, since it better captures managerial flexibility and the handling of NPV considering project volatility.
DOI: 10.6084/m9.figshare.8988236
title: Influence of Mechanical Cycling on Residual Strain in Superelastic Cu-Al-Be-Nb Alloys

description: The understanding of the stabilization mechanism of martensite used to obtain alloys with high hysteresis and the possibility of recovering this martensite (residual strain) by heating at temperatures higher than As and Af have been fundamental for application in bonding devices. One of the possibilities to enhance residual strain is through mechanical cycling. This work evaluated the influence of number of cycles and the effect of precipitation of Nb-rich particles as mechanisms to increase residual strain in superelastic Cu-Al-Be-Nb alloys. The results showed that the presence of Nb-rich precipitates was not a predominant factor for the enhancement of residual strain. In addition, mechanical cycling has proved to be an efficient mechanism for raising residual strain, and consequently increasing the amount of martensite retained. However, the gain of residual strain is accompanied by an increase of plastic deformation.
DOI: 10.6084/m9.figshare.8988239
title: MICROBIAL METABOLOMICS: INNOVATIONS AND APPLICATIONS

description: Over the past few years, metabolomics has been employed in a broad range of applications in different research fields. Microbial metabolomics has been applied in several microbiological areas, such as identification of microorganisms, cell mutations, functional gene approach, identification of unique metabolic pathways and microbial engineering, leading to a better understanding of the global metabolism and metabolic regulation of certain systems. Metabolites produced by microorganisms constitute a large promising group with diverse applications; however, most of these systems are still unknown and underexplored. In this context, the overall analysis of metabolites involved in a biological system can be used to discover potential biomarkers or specific metabolic changes due to a biological phenomenon studied. In this sense, this review aims to understand the main challenges faced by each step of the workflow in the metabolic analysis of microorganisms and how these difficulties have been overcome. A critical analysis of the articles published within the last five years will be accomplished in this paper to understand how these studies have contributed to the microbial metabolomics research. Moreover, major trends observed in this area will be highlighted here in order to guide readers interested in microbial metabolomics in their future researches.
DOI: 10.6084/m9.figshare.8988242.v1
title: Analysis of real options applied in the diversification of rural production in Paraná state

description: Abstract The objective of this paper is to analyze the contribution of the use of the Real Options Theory (TOR) in the investments analysis of the diversification of rural production in Paraná state (Brazil). It is an exploratory research, with a technical documental procedure, of quantitative character, using primary and secondary sources, in cross-section and statistical analysis of a case study on the analysis of the financial viability and the distribution of probabilities by TOR in an investment project of diversification in agricultural production. The cash flow was based on data from suppliers and information collected on the Secretariat of Agriculture of Paraná State (Seab) website, in relation to coffee, cassava, corn, soybean and wheat crops. The analysis consisted in calculating the present value using traditional investment analysis methods such as NPV, TIR and Payback, and the real options through the binomial tree for comparability. The results show that the Real Options Theory is a more accurate method to calculate the present value in projects of diversification of rural production, since it better captures managerial flexibility and the handling of NPV considering project volatility.
DOI: 10.6084/m9.figshare.8988236.v1
title: Influence of Mechanical Cycling on Residual Strain in Superelastic Cu-Al-Be-Nb Alloys

description: The understanding of the stabilization mechanism of martensite used to obtain alloys with high hysteresis and the possibility of recovering this martensite (residual strain) by heating at temperatures higher than As and Af have been fundamental for application in bonding devices. One of the possibilities to enhance residual strain is through mechanical cycling. This work evaluated the influence of number of cycles and the effect of precipitation of Nb-rich particles as mechanisms to increase residual strain in superelastic Cu-Al-Be-Nb alloys. The results showed that the presence of Nb-rich precipitates was not a predominant factor for the enhancement of residual strain. In addition, mechanical cycling has proved to be an efficient mechanism for raising residual strain, and consequently increasing the amount of martensite retained. However, the gain of residual strain is accompanied by an increase of plastic deformation.
DOI: 10.6084/m9.figshare.8988239.v1
title: MICROBIAL METABOLOMICS: INNOVATIONS AND APPLICATIONS

description: Over the past few years, metabolomics has been employed in a broad range of applications in different research fields. Microbial metabolomics has been applied in several microbiological areas, such as identification of microorganisms, cell mutations, functional gene approach, identification of unique metabolic pathways and microbial engineering, leading to a better understanding of the global metabolism and metabolic regulation of certain systems. Metabolites produced by microorganisms constitute a large promising group with diverse applications; however, most of these systems are still unknown and underexplored. In this context, the overall analysis of metabolites involved in a biological system can be used to discover potential biomarkers or specific metabolic changes due to a biological phenomenon studied. In this sense, this review aims to understand the main challenges faced by each step of the workflow in the metabolic analysis of microorganisms and how these difficulties have been overcome. A critical analysis of the articles published within the last five years will be accomplished in this paper to understand how these studies have contributed to the microbial metabolomics research. Moreover, major trends observed in this area will be highlighted here in order to guide readers interested in microbial metabolomics in their future researches.
DOI: 10.6084/m9.figshare.8988230
title: Effect Of The Application Of Constant And Variable Temperatures at the Overaging Stage in the Mechanical Properties of Trip780 Steel

description: The effect of the application of constant temperatures (isothermal plateau) and variables (cooling ramp) during the overaging (OA) stage of the continuous annealing cycle in the microstructural characteristics and mechanical properties of a TRIP steel of the class of 780 MPa was investigated. It was simulated six overaging conditions in the equipment Gleeble. The microstructures presented variable fractions of ferrite, bainite, retained austenite and a small martensite portion. All the conditions achieved the minimum strength of 780 MPa it is possible to highlight the conditions for initial OA temperature of 440 °C where presented the best results of mechanical properties and typical TRIP steels behaviors.
DOI: 10.6084/m9.figshare.8988233
title: What is the appropriate time to measure outcome and process factors in psychodynamic psychotherapy?

description: Abstract Introduction Different instruments and methods for measuring factors related to the progress and effectiveness of psychodynamic psychotherapy (PDT) have been widely discussed in the literature. However, there are no established guidelines on the most appropriate time to perform these measurements. Objectives The aim of this study is to problematize what is the appropriate time to measure the initial outcomes (symptoms, interpersonal relationships, quality, and social role) and process factors (alliance) in the early stages of PDT. Methods A naturalistic cohort study was conducted, following 304 patients during the first six months of psychotherapy. The therapeutic alliance was evaluated after four sessions; symptoms, interpersonal relationships, and social role were evaluated at intake and after 12 and 24 sessions. Results Our results indicate that four sessions were sufficient to measure the bond dimension of the therapeutic alliance, while more time is probably needed to adequately measure other aspects of the therapeutic alliance, such as tasks and goals. However, 12 sessions of treatment proved sufficient to detect improvements in all dimensions of the outcome instruments with moderate effect sizes, and those gains were stable at the 24th session. Conclusion According to our findings, 12 sessions seem to be sufficient to assess initial gains in PDT, although more studies are needed to evaluate the appropriate time to assess all aspects of the therapeutic alliance. Further studies are also required to evaluate the appropriate time to assess intermediate and long-term progress with regard to symptoms, interpersonal relations, social role and personality reorganization.
DOI: 10.6084/m9.figshare.8988227
title: Influence of the Gas Pressure of Plasma Nitriding on the Structural, Mechanical and Tribological Surface Properties of AISI 316L

description: In this paper, the influence of gas nitriding (80% H2-20% N2) pressure (between 3 and 7 Torr) on the modification of surface properties of AISI 316L stainless steel is examined. The structural, mechanical, tribological and electrochemical properties of the layer produced in disk samples were studied. The samples’ characteristics were determined by scanning electron microscopy, X-ray diffraction, electrochemical potential curves, microhardness, roughness and wear tests. When pressure increases, the microhardness, elasticity and thickness also increase. The maximum thickness of the nitrided layer was 6.4 µm, the hardness reached 2200 HV0.0036 and the mass loss decreased until 1% relatively to the unnitrided sample. The X-ray diffractograms showed the presence of the expanded austenite in all the samples. The correlation between these diffractograms and the corrosion results corroborate to the most recent previous conclusions of our systematic study, which evince the interconnection between the improvement of the corrosion resistance and the presence of nitrides on the top of the nitrided layer. More significant presence of such nitrides was observed for the sample nitrided at 6 Torr, whose corrosion performance was better than for the other samples. This pressure seems to be the most indicated to improve the properties under study. Moreover, the results verified not only that the sample geometry is an important factor for enhancing these properties but also that the border effect, which causes the rings on the disk border, depends on the pressure, but not on temperature or time from the plasma nitriding process.
DOI: 10.6084/m9.figshare.8988230.v1
title: Effect Of The Application Of Constant And Variable Temperatures at the Overaging Stage in the Mechanical Properties of Trip780 Steel

description: The effect of the application of constant temperatures (isothermal plateau) and variables (cooling ramp) during the overaging (OA) stage of the continuous annealing cycle in the microstructural characteristics and mechanical properties of a TRIP steel of the class of 780 MPa was investigated. It was simulated six overaging conditions in the equipment Gleeble. The microstructures presented variable fractions of ferrite, bainite, retained austenite and a small martensite portion. All the conditions achieved the minimum strength of 780 MPa it is possible to highlight the conditions for initial OA temperature of 440 °C where presented the best results of mechanical properties and typical TRIP steels behaviors.
DOI: 10.6084/m9.figshare.8988233.v1
title: What is the appropriate time to measure outcome and process factors in psychodynamic psychotherapy?

description: Abstract Introduction Different instruments and methods for measuring factors related to the progress and effectiveness of psychodynamic psychotherapy (PDT) have been widely discussed in the literature. However, there are no established guidelines on the most appropriate time to perform these measurements. Objectives The aim of this study is to problematize what is the appropriate time to measure the initial outcomes (symptoms, interpersonal relationships, quality, and social role) and process factors (alliance) in the early stages of PDT. Methods A naturalistic cohort study was conducted, following 304 patients during the first six months of psychotherapy. The therapeutic alliance was evaluated after four sessions; symptoms, interpersonal relationships, and social role were evaluated at intake and after 12 and 24 sessions. Results Our results indicate that four sessions were sufficient to measure the bond dimension of the therapeutic alliance, while more time is probably needed to adequately measure other aspects of the therapeutic alliance, such as tasks and goals. However, 12 sessions of treatment proved sufficient to detect improvements in all dimensions of the outcome instruments with moderate effect sizes, and those gains were stable at the 24th session. Conclusion According to our findings, 12 sessions seem to be sufficient to assess initial gains in PDT, although more studies are needed to evaluate the appropriate time to assess all aspects of the therapeutic alliance. Further studies are also required to evaluate the appropriate time to assess intermediate and long-term progress with regard to symptoms, interpersonal relations, social role and personality reorganization.
DOI: 10.6084/m9.figshare.8988221
title: Treatment of type 1A endoleak using coil embolization: a case report

description: Abstract In a type 1A endoleak, the endograft is unable to fully seal the proximal aneurysm neck and blood flow leaks between the wall of the aortic neck and the graft material. This article reports a case in which coil embolization was used and presents a literature review (PubMed, LILACS, and SciELO). Searches were run for articles published in the past 5 years using the descriptors “endoleak 1A”, “coil embolization,” and “treatment”. Type 1A endoleak occurs in 1.1% of patients within 30 days of graft placement. Treatment of an endoleak is obligatory and usually consists of sealing the proximal graft neck using stents and balloons to expand the landing zone or to increase the radial force of the graft. Some studies have suggested using embolization techniques with cyanoacrylate, fibrin glue, and Onyx, demonstrating success rates that exceed 97%. However, correction of type 1A endoleak using coil embolization has seldom been described.
DOI: 10.6084/m9.figshare.8988215
title: Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type

description: Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. METHODS: The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. RESULTS: Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. CONCLUSIONS: The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM.
DOI: 10.6084/m9.figshare.8988221.v1
title: Treatment of type 1A endoleak using coil embolization: a case report

description: Abstract In a type 1A endoleak, the endograft is unable to fully seal the proximal aneurysm neck and blood flow leaks between the wall of the aortic neck and the graft material. This article reports a case in which coil embolization was used and presents a literature review (PubMed, LILACS, and SciELO). Searches were run for articles published in the past 5 years using the descriptors “endoleak 1A”, “coil embolization,” and “treatment”. Type 1A endoleak occurs in 1.1% of patients within 30 days of graft placement. Treatment of an endoleak is obligatory and usually consists of sealing the proximal graft neck using stents and balloons to expand the landing zone or to increase the radial force of the graft. Some studies have suggested using embolization techniques with cyanoacrylate, fibrin glue, and Onyx, demonstrating success rates that exceed 97%. However, correction of type 1A endoleak using coil embolization has seldom been described.
DOI: 10.6084/m9.figshare.8988227.v1
title: Influence of the Gas Pressure of Plasma Nitriding on the Structural, Mechanical and Tribological Surface Properties of AISI 316L

description: In this paper, the influence of gas nitriding (80% H2-20% N2) pressure (between 3 and 7 Torr) on the modification of surface properties of AISI 316L stainless steel is examined. The structural, mechanical, tribological and electrochemical properties of the layer produced in disk samples were studied. The samples’ characteristics were determined by scanning electron microscopy, X-ray diffraction, electrochemical potential curves, microhardness, roughness and wear tests. When pressure increases, the microhardness, elasticity and thickness also increase. The maximum thickness of the nitrided layer was 6.4 µm, the hardness reached 2200 HV0.0036 and the mass loss decreased until 1% relatively to the unnitrided sample. The X-ray diffractograms showed the presence of the expanded austenite in all the samples. The correlation between these diffractograms and the corrosion results corroborate to the most recent previous conclusions of our systematic study, which evince the interconnection between the improvement of the corrosion resistance and the presence of nitrides on the top of the nitrided layer. More significant presence of such nitrides was observed for the sample nitrided at 6 Torr, whose corrosion performance was better than for the other samples. This pressure seems to be the most indicated to improve the properties under study. Moreover, the results verified not only that the sample geometry is an important factor for enhancing these properties but also that the border effect, which causes the rings on the disk border, depends on the pressure, but not on temperature or time from the plasma nitriding process.