cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20402478
title: Supplementary Material for: Acidic skin care promotes cutaneous microbiome recovery and skin physiology in an acute stratum corneum stress model

description: Introduction: Skin microbiome and skin physiology are important indicators of the epidermal homeostasis status. Stress models can reveal pathological conditions and modulating effects. Here we investigated the cutaneous microbiome in relation to skin physiology after mild tape stripping (TS) without treatment compared to two cosmetic leave-on lotions (pH 5.5 vs. pH 9.3) in 25 healthy volunteers. Methods: The microbiome was analyzed by 16S-rRNA-gene amplicon sequencing and put in relation to the following skin physiology parameter: epidermal barrier function (TEWA-Meter TM300), stratum corneum hydration (Corneometer CM 825), surface pH (pH-Meter) and skin erythema (Mexameter). Results: TS reduced the alpha diversity with a recovery over 7 days without treatment. Both lotions significantly accelerated the recovery of the alpha-diversity already after 2 days with a slightly higher rate for the acidic lotion. After TS, the relative abundance of Proteobacteria was increased, whereas Actinobacteria were reduced. The relative abundances of typical skin-associated genera were reduced after TS. Taxa compositions returned to normal levels after 7 days in all treatment groups. An accelerated normalization could be observed with both lotions already after two days. A significant difference in skin pH was observed on day2 and day7 with an increased pH for the alkaline lotion. Both lotions induced an increase in stratum corneum hydration. Conclusion: The study proved the suitability of an experimental stress model in the assessment of skin surface microbiome in relation to skin physiology. Stratum corneum hydration increased significantly with both lotions already at day2. Microbiome parameters (alpha-diversity, mean relative taxa, abundance of selected genera) normalized over 2-7 days. The following mechanisms could be responsible for the accelerated normalization of the microbiome: a) optimized hydration during the recovery phase, b) the composition of the lotion c) the induced repair mechanism. Thus, the formulation has a positive effect on the stratum corneum hydration and subsequently on cutaneous microbiome and skin physiology. Furthermore, this has eventually implications in the modulation of exogenous stress-induced epidermal alterations.
DOI: 10.6084/m9.figshare.20402478.v1
title: Supplementary Material for: Acidic skin care promotes cutaneous microbiome recovery and skin physiology in an acute stratum corneum stress model

description: Introduction: Skin microbiome and skin physiology are important indicators of the epidermal homeostasis status. Stress models can reveal pathological conditions and modulating effects. Here we investigated the cutaneous microbiome in relation to skin physiology after mild tape stripping (TS) without treatment compared to two cosmetic leave-on lotions (pH 5.5 vs. pH 9.3) in 25 healthy volunteers. Methods: The microbiome was analyzed by 16S-rRNA-gene amplicon sequencing and put in relation to the following skin physiology parameter: epidermal barrier function (TEWA-Meter TM300), stratum corneum hydration (Corneometer CM 825), surface pH (pH-Meter) and skin erythema (Mexameter). Results: TS reduced the alpha diversity with a recovery over 7 days without treatment. Both lotions significantly accelerated the recovery of the alpha-diversity already after 2 days with a slightly higher rate for the acidic lotion. After TS, the relative abundance of Proteobacteria was increased, whereas Actinobacteria were reduced. The relative abundances of typical skin-associated genera were reduced after TS. Taxa compositions returned to normal levels after 7 days in all treatment groups. An accelerated normalization could be observed with both lotions already after two days. A significant difference in skin pH was observed on day2 and day7 with an increased pH for the alkaline lotion. Both lotions induced an increase in stratum corneum hydration. Conclusion: The study proved the suitability of an experimental stress model in the assessment of skin surface microbiome in relation to skin physiology. Stratum corneum hydration increased significantly with both lotions already at day2. Microbiome parameters (alpha-diversity, mean relative taxa, abundance of selected genera) normalized over 2-7 days. The following mechanisms could be responsible for the accelerated normalization of the microbiome: a) optimized hydration during the recovery phase, b) the composition of the lotion c) the induced repair mechanism. Thus, the formulation has a positive effect on the stratum corneum hydration and subsequently on cutaneous microbiome and skin physiology. Furthermore, this has eventually implications in the modulation of exogenous stress-induced epidermal alterations.
DOI: 10.6084/m9.figshare.20282106
title: Supplementary Material for: Role of Proxy Respondents in International Stroke Research: Experience of the INTERSTROKE Study

description: Introduction Measuring patient-reported information in stroke research is challenging. To overcome this, use of proxy respondents is often a necessary strategy. In this study, we report on use and effect of proxy respondents on patient case-mix in a large international epidemiologic stroke study (INTERSTROKE). Methods This was a cross-sectional study of 13,458 cases of acute first stroke in 32 countries. A standardised study questionnaire recording behavioural cardiovascular risk factors was administered to the patient, and if unable to communicate adequately, a valid proxy, or both. We used logistic regression to evaluate the association of age, sex, education, occupation, stroke severity and region with need for proxy respondent, and report odds ratio (OR) with 95%CI. Results Among 13,458 participants with acute stroke, questionnaires were completed by patients alone in 41.4% (n=5573), combination of patient and proxy together in 21.7% (n=2,918) and proxy alone in 36.9% (n=4967). Use of proxy alone was greater in participants with severe stroke (4.7% with modified-Rankin score of 0 versus 80.5% in those with score 5; OR 187.13; 95% CI 119.61-308.22) older persons (43.8% of those aged 80 years and over versus 33.2% of those aged less than 40 years; age per decade OR 1.09; 95% CI 1.06-1.12), women (40.7% versus 34.3% of men; OR 1.32 95% CI 1.22-1.43); and those less educated (58.9% of those never educated versus 25.7% of those who attended third level education; OR 7.84; 95% CI 6.78-9.08). Conclusion Use of proxy respondents enhances the generalisability of international research studies of stroke, by increasing representation of women, patients with severe stroke, older age, and lower education.
DOI: 10.6084/m9.figshare.20282106.v1
title: Supplementary Material for: Role of Proxy Respondents in International Stroke Research: Experience of the INTERSTROKE Study

description: Introduction Measuring patient-reported information in stroke research is challenging. To overcome this, use of proxy respondents is often a necessary strategy. In this study, we report on use and effect of proxy respondents on patient case-mix in a large international epidemiologic stroke study (INTERSTROKE). Methods This was a cross-sectional study of 13,458 cases of acute first stroke in 32 countries. A standardised study questionnaire recording behavioural cardiovascular risk factors was administered to the patient, and if unable to communicate adequately, a valid proxy, or both. We used logistic regression to evaluate the association of age, sex, education, occupation, stroke severity and region with need for proxy respondent, and report odds ratio (OR) with 95%CI. Results Among 13,458 participants with acute stroke, questionnaires were completed by patients alone in 41.4% (n=5573), combination of patient and proxy together in 21.7% (n=2,918) and proxy alone in 36.9% (n=4967). Use of proxy alone was greater in participants with severe stroke (4.7% with modified-Rankin score of 0 versus 80.5% in those with score 5; OR 187.13; 95% CI 119.61-308.22) older persons (43.8% of those aged 80 years and over versus 33.2% of those aged less than 40 years; age per decade OR 1.09; 95% CI 1.06-1.12), women (40.7% versus 34.3% of men; OR 1.32 95% CI 1.22-1.43); and those less educated (58.9% of those never educated versus 25.7% of those who attended third level education; OR 7.84; 95% CI 6.78-9.08). Conclusion Use of proxy respondents enhances the generalisability of international research studies of stroke, by increasing representation of women, patients with severe stroke, older age, and lower education.
DOI: 10.6084/m9.figshare.20625900.v1
title: The studied papers

description: A list of studied papers during a review study on Volunteered Geographic Information (VGI) challenges.
DOI: 10.6084/m9.figshare.20625900
title: The studied papers

description: A list of studied papers during a review study on Volunteered Geographic Information (VGI) challenges.
DOI: 10.6084/m9.figshare.20626322
title: Additional file 10 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 10: File S5. Design and details of donor samples used to construct the Hybrid TMA for rapid validation of biomarkers identified in mass spectrometric studies.
DOI: 10.6084/m9.figshare.20626322.v1
title: Additional file 10 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 10: File S5. Design and details of donor samples used to construct the Hybrid TMA for rapid validation of biomarkers identified in mass spectrometric studies.
DOI: 10.6084/m9.figshare.20626325
title: Additional file 11 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 11.
DOI: 10.6084/m9.figshare.20626325.v1
title: Additional file 11 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 11.
DOI: 10.6084/m9.figshare.20626328.v1
title: Additional file 12 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 12.
DOI: 10.6084/m9.figshare.20626328
title: Additional file 12 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 12.
DOI: 10.6084/m9.figshare.20626346
title: Additional file 6 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 6: File S1. Proteome Discoverer Output of identified proteins and phosphoproteins with comprehensive list of peptides detected by mass spectrometry.
DOI: 10.6084/m9.figshare.20626346.v1
title: Additional file 6 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 6: File S1. Proteome Discoverer Output of identified proteins and phosphoproteins with comprehensive list of peptides detected by mass spectrometry.
DOI: 10.6084/m9.figshare.20626349
title: Additional file 7 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 7: File S2. Clusters identified in the proteome and phosphoproteome in EVs. Only those proteins were considered as identified hits, which had three values in any one triplicate condition.
DOI: 10.6084/m9.figshare.20626349.v1
title: Additional file 7 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 7: File S2. Clusters identified in the proteome and phosphoproteome in EVs. Only those proteins were considered as identified hits, which had three values in any one triplicate condition.
DOI: 10.6084/m9.figshare.20626355
title: Additional file 9 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 9: File S4. Reactome analyses of proteins and phosphoproteins identified by mass spectrometric characterization of EVs secreted from cell culture conditions.
DOI: 10.6084/m9.figshare.20626355.v1
title: Additional file 9 of Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment

description: Additional file 9: File S4. Reactome analyses of proteins and phosphoproteins identified by mass spectrometric characterization of EVs secreted from cell culture conditions.
DOI: 10.6084/m9.figshare.20626357
title: Additional file 1 of Impact of combined versus single-mode training programs based on drop jump and specific multidirectional repeated sprint on bio-motor ability adaptations: a parallel study design in professional basketball players

description: Additional file 1. All additional information for trainers.
DOI: 10.6084/m9.figshare.20626357.v1
title: Additional file 1 of Impact of combined versus single-mode training programs based on drop jump and specific multidirectional repeated sprint on bio-motor ability adaptations: a parallel study design in professional basketball players

description: Additional file 1. All additional information for trainers.
DOI: 10.5281/zenodo.5804184
title: Proteomic and Metabolomic Revealed Differences in the Distribution and Synthesis Mechanism of Aroma Precursors in Yunyan 87 Tobacco Leaf, Stem, and Root at the Seedling Stage

description: abstract
DOI: 10.5281/zenodo.5804183
title: Proteomic and Metabolomic Revealed Differences in the Distribution and Synthesis Mechanism of Aroma Precursors in Yunyan 87 Tobacco Leaf, Stem, and Root at the Seedling Stage

description: abstract
DOI: 10.6084/m9.figshare.20521974
title: Butovskaya_et_al_Resource_Allocation_in_Children

description: The dataset contains information on gender, age, ethnicity, location, and decisions in 6 experimental games (Prosocial, Envy, Sharing games - based on Fehr et al., 2008) for 2253 children and adolescents from 7 economically and culturally diverse societies (Hadza, Iraqw, Meru, Haya, Buryats, Tuvans, and Russians).
DOI: 10.6084/m9.figshare.20521974.v1
title: Butovskaya_et_al_Resource_Allocation_in_Children

description: The dataset contains information on gender, age, ethnicity, location, and decisions in 6 experimental games (Prosocial, Envy, Sharing games - based on Fehr et al., 2008) for 2253 children and adolescents from 7 economically and culturally diverse societies (Hadza, Iraqw, Meru, Haya, Buryats, Tuvans, and Russians).
DOI: 10.6084/m9.figshare.20626455
title: A school of thought on VGI challenges: a literature review

description: A list of studied papers during a review study on Volunteered Geographic Information (VGI) challenges.
DOI: 10.6084/m9.figshare.20626455.v1
title: The list of the studied papers

description: A list of studied papers during a review study on Volunteered Geographic Information (VGI) challenges.
DOI: 10.6084/m9.figshare.20626455.v2
title: A school of thought on VGI challenges: a literature review

description: A list of studied papers during a review study on Volunteered Geographic Information (VGI) challenges.
DOI: 10.5525/gla.researchdata.1111
title: Modelling an unconventional closed-loop deep borehole heat exchanger (DBHE): Sensitivity Analysis on the Newberry Volcanic Setting
DOI: 10.6084/m9.figshare.20626605
title: Supplementary Material for: Dietary fat composition affects hepatic angiogenesis and lymphangiogenesis in HCV core gene transgenic mice

description: Introduction: Previous research has demonstrated that an isocaloric diet rich in trans fatty acid (TFA), saturated fatty acid (SFA), and cholesterol (Chol) promoted steatosis-derived hepatic tumorigenesis in hepatitis C virus core gene transgenic (HCVcpTg) mice in different manners. Growth factor signaling and ensuing angiogenesis/lymphangiogenesis are key factors in hepatic tumorigenesis that have become recent therapeutic targets for hepatocellular carcinoma. However, the influence of dietary fat composition on these factors remains unclear. This study investigated whether the type of dietary fat would have a specific impact on hepatic angiogenesis/lymphangiogenesis in HCVcpTg mice. Methods: Male HCVcpTg mice were treated with a control diet, an isocaloric diet containing 1.5% cholesterol (Chol diet), or a diet replacing soybean oil with hydrogenated coconut oil (SFA diet) for a period of 15 months, or with shortening (TFA diet) for 5 months. The degree of angiogenesis/lymphangiogenesis and the expression of growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), were evaluated in non-tumorous liver tissues using quantitative mRNA measurement, immunoblot analysis, and immunohistochemistry. Results: Long-term feeding of SFA and TFA diets to HCVcpTg mice increased the expressions of vascular endothelial cell indicators, such as CD31 and TEK tyrosine kinase, in addition to lymphatic vessel endothelial hyaluronan receptor 1, indicating that angiogenesis/lymphangiogenesis were up-regulated only by these fatty acid-enriched diets. This promoting effect correlated with elevated VEGF-C and FGF receptor 2 and 3 levels in the liver. c-Jun N-terminal kinase (JNK) and hypoxia-inducible factor (HIF) 1α, both key regulators of VEGF-C expression, were enhanced in the SFA- and TFA-rich diet groups as well. The Chol diet significantly increased the expressions of such growth factors as FGF2 and PDGF subunit B (PDGF-B), without any detectable impact on angiogenesis/lymphangiogenesis. Conclusion: This study revealed that diets rich in SFA and TFA, but not Chol, might stimulate hepatic angiogenesis/lymphangiogenesis mainly through the JNK-HIF1α-VEGF-C axis. Our observations indicate an importance of dietary fat species for preventing hepatic tumorigenesis.
DOI: 10.6084/m9.figshare.20626605.v1
title: Supplementary Material for: Dietary fat composition affects hepatic angiogenesis and lymphangiogenesis in HCV core gene transgenic mice

description: Introduction: Previous research has demonstrated that an isocaloric diet rich in trans fatty acid (TFA), saturated fatty acid (SFA), and cholesterol (Chol) promoted steatosis-derived hepatic tumorigenesis in hepatitis C virus core gene transgenic (HCVcpTg) mice in different manners. Growth factor signaling and ensuing angiogenesis/lymphangiogenesis are key factors in hepatic tumorigenesis that have become recent therapeutic targets for hepatocellular carcinoma. However, the influence of dietary fat composition on these factors remains unclear. This study investigated whether the type of dietary fat would have a specific impact on hepatic angiogenesis/lymphangiogenesis in HCVcpTg mice. Methods: Male HCVcpTg mice were treated with a control diet, an isocaloric diet containing 1.5% cholesterol (Chol diet), or a diet replacing soybean oil with hydrogenated coconut oil (SFA diet) for a period of 15 months, or with shortening (TFA diet) for 5 months. The degree of angiogenesis/lymphangiogenesis and the expression of growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), were evaluated in non-tumorous liver tissues using quantitative mRNA measurement, immunoblot analysis, and immunohistochemistry. Results: Long-term feeding of SFA and TFA diets to HCVcpTg mice increased the expressions of vascular endothelial cell indicators, such as CD31 and TEK tyrosine kinase, in addition to lymphatic vessel endothelial hyaluronan receptor 1, indicating that angiogenesis/lymphangiogenesis were up-regulated only by these fatty acid-enriched diets. This promoting effect correlated with elevated VEGF-C and FGF receptor 2 and 3 levels in the liver. c-Jun N-terminal kinase (JNK) and hypoxia-inducible factor (HIF) 1α, both key regulators of VEGF-C expression, were enhanced in the SFA- and TFA-rich diet groups as well. The Chol diet significantly increased the expressions of such growth factors as FGF2 and PDGF subunit B (PDGF-B), without any detectable impact on angiogenesis/lymphangiogenesis. Conclusion: This study revealed that diets rich in SFA and TFA, but not Chol, might stimulate hepatic angiogenesis/lymphangiogenesis mainly through the JNK-HIF1α-VEGF-C axis. Our observations indicate an importance of dietary fat species for preventing hepatic tumorigenesis.
DOI: 10.6084/m9.figshare.20626623
title: Supplementary Material for: Dietary fat composition affects hepatic angiogenesis and lymphangiogenesis in HCV core gene transgenic mice

description: Introduction: Previous research has demonstrated that an isocaloric diet rich in trans fatty acid (TFA), saturated fatty acid (SFA), and cholesterol (Chol) promoted steatosis-derived hepatic tumorigenesis in hepatitis C virus core gene transgenic (HCVcpTg) mice in different manners. Growth factor signaling and ensuing angiogenesis/lymphangiogenesis are key factors in hepatic tumorigenesis that have become recent therapeutic targets for hepatocellular carcinoma. However, the influence of dietary fat composition on these factors remains unclear. This study investigated whether the type of dietary fat would have a specific impact on hepatic angiogenesis/lymphangiogenesis in HCVcpTg mice. Methods: Male HCVcpTg mice were treated with a control diet, an isocaloric diet containing 1.5% cholesterol (Chol diet), or a diet replacing soybean oil with hydrogenated coconut oil (SFA diet) for a period of 15 months, or with shortening (TFA diet) for 5 months. The degree of angiogenesis/lymphangiogenesis and the expression of growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), were evaluated in non-tumorous liver tissues using quantitative mRNA measurement, immunoblot analysis, and immunohistochemistry. Results: Long-term feeding of SFA and TFA diets to HCVcpTg mice increased the expressions of vascular endothelial cell indicators, such as CD31 and TEK tyrosine kinase, in addition to lymphatic vessel endothelial hyaluronan receptor 1, indicating that angiogenesis/lymphangiogenesis were up-regulated only by these fatty acid-enriched diets. This promoting effect correlated with elevated VEGF-C and FGF receptor 2 and 3 levels in the liver. c-Jun N-terminal kinase (JNK) and hypoxia-inducible factor (HIF) 1α, both key regulators of VEGF-C expression, were enhanced in the SFA- and TFA-rich diet groups as well. The Chol diet significantly increased the expressions of such growth factors as FGF2 and PDGF subunit B (PDGF-B), without any detectable impact on angiogenesis/lymphangiogenesis. Conclusion: This study revealed that diets rich in SFA and TFA, but not Chol, might stimulate hepatic angiogenesis/lymphangiogenesis mainly through the JNK-HIF1α-VEGF-C axis. Our observations indicate an importance of dietary fat species for preventing hepatic tumorigenesis.