cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30759571.v1
title: Unveiling the prognostic and immunological role of IFI44 in glioma

description: Gliomas are aggressive central nervous system tumors with limited understanding of their molecular drivers. Identifying novel prognostic and therapeutic biomarkers remains crucial. Using TCGA, GTEx, GEO, and CGGA datasets, we performed differential expression, Cox regression, and LASSO analyses to identify prognostic genes. IFI44, one of eight significant candidates, was analyzed for its association with survival, clinical features (IDH mutation, 1p/19q codeletion) and tumor immune microenvironment. Functional assays were conducted to evaluate its effects on glioma cell proliferation, migration, and invasion. Transcriptomic analysis of 1,142 normal and 398 glioma samples identified 61 consistently dysregulated genes, predominantly enriched in immune-related rather than classical oncogenic pathways. In CGGA cohorts, eight progression-associated genes were identified, six associated with poor prognosis. IFI44 expression correlated with higher grade, older age, IDH wild type, and 1p/19q non-codeletion. High IFI44 tumors were enriched for NF1 mutations, while low IFI44 tumors carried IDH1, NOTCH1, and CIC mutations. Mechanistically, IFI44-high gliomas exhibited immune-suppressive pathway enrichment, increased checkpoint expression (PD-1/PD-L1, CTLA4, LAG3), and macrophage infiltration. Protein interaction analysis linked IFI44 to cytokine signaling and T-cell regulation. In U87 and U251 cells, IFI44 overexpression promoted proliferation, migration, and invasion, whereas knockdown suppressed these phenotypes. IFI44 may drive glioma progression through dual mechanisms of immune microenvironment remodeling and promotion of tumor cell aggressiveness, supporting its potential as a prognostic biomarker and therapeutic target. Although preliminary knockdown and overexpression assays were performed, the underlying mechanisms of IFI44-mediated immune regulation and tumor progression require further investigation.
DOI: 10.6084/m9.figshare.29548380
title: Prognostic value of sarcopenia in patients with nasopharyngeal carcinoma: a meta-analysis

description: Sarcopenia is widely explored for its significance for predicting nasopharyngeal carcinoma (NPC) prognosis, yet current results are inconsistent. Consequently, this meta-analysis focused on investigating its precise role in predicting NPC prognosis. We systemically retrieved studies in PubMed, Web of Science, Embase and Cochrane Library from inception to 17 March 2025. Sarcopenia was analysed for its role in predicting overall survival (OS) and progression-free survival (PFS) in NPC through determining combined hazard ratios (HRs) and 95% confidence intervals (CIs). Thereafter, associations of sarcopenia with NPC clinicopathological factors were estimated through aggregating odds ratios (ORs) with 95%CIs. There were eight studies with 5458 cases enrolled in this study. Based on the aggregated findings, sarcopenia was remarkably related to unfavourable OS (HR = 1.88, 95% CI = 1.47–2.40, <i>p</i> &lt; .001) as well as PFS (HR = 2.03, 95%CI = 1.48–2.80, <i>p</i> &lt; .001) of NPC. Moreover, sarcopenia was significantly associated with higher T stage (OR = 1.33, 95%CI = 1.12–1.59, <i>p</i> = .002). But it was not related to gender (OR = 0.87, 95%CI = 0.42–1.77, <i>p</i> = .694), N stage (OR = 1.00, 95%CI = 0.87–1.16, <i>p</i> = .952) and tumour-node-metastasis (TNM) stage (OR = 1.17, 95%CI = 0.94–1.46, <i>p</i> = .153) in NPC. This meta-analysis demonstrated that sarcopenia was a significant prognostic marker for poor OS and PFS in patients with NPC. Moreover, sarcopenia was also significantly associated with higher T stage of NPC. To our knowledge, the current work provides the first meta-analysis investigating the value of sarcopenia for predicting NPC prognosis. Sarcopenia was a significant prognostic marker for poor OS and PFS in patients with NPC. Sarcopenia was also significantly associated with higher T stage of NPC.
DOI: 10.6084/m9.figshare.29548380.v1
title: Prognostic value of sarcopenia in patients with nasopharyngeal carcinoma: a meta-analysis

description: Sarcopenia is widely explored for its significance for predicting nasopharyngeal carcinoma (NPC) prognosis, yet current results are inconsistent. Consequently, this meta-analysis focused on investigating its precise role in predicting NPC prognosis. We systemically retrieved studies in PubMed, Web of Science, Embase and Cochrane Library from inception to 17 March 2025. Sarcopenia was analysed for its role in predicting overall survival (OS) and progression-free survival (PFS) in NPC through determining combined hazard ratios (HRs) and 95% confidence intervals (CIs). Thereafter, associations of sarcopenia with NPC clinicopathological factors were estimated through aggregating odds ratios (ORs) with 95%CIs. There were eight studies with 5458 cases enrolled in this study. Based on the aggregated findings, sarcopenia was remarkably related to unfavourable OS (HR = 1.88, 95% CI = 1.47–2.40, <i>p</i> &lt; .001) as well as PFS (HR = 2.03, 95%CI = 1.48–2.80, <i>p</i> &lt; .001) of NPC. Moreover, sarcopenia was significantly associated with higher T stage (OR = 1.33, 95%CI = 1.12–1.59, <i>p</i> = .002). But it was not related to gender (OR = 0.87, 95%CI = 0.42–1.77, <i>p</i> = .694), N stage (OR = 1.00, 95%CI = 0.87–1.16, <i>p</i> = .952) and tumour-node-metastasis (TNM) stage (OR = 1.17, 95%CI = 0.94–1.46, <i>p</i> = .153) in NPC. This meta-analysis demonstrated that sarcopenia was a significant prognostic marker for poor OS and PFS in patients with NPC. Moreover, sarcopenia was also significantly associated with higher T stage of NPC. To our knowledge, the current work provides the first meta-analysis investigating the value of sarcopenia for predicting NPC prognosis. Sarcopenia was a significant prognostic marker for poor OS and PFS in patients with NPC. Sarcopenia was also significantly associated with higher T stage of NPC.
DOI: 10.6084/m9.figshare.30928073
title: Prognostic relevance of bone marrow immune cell fractions in newly diagnosed B-cell non-Hodgkin lymphoma patients

description: Non-Hodgkin lymphomas (NHLs) are the most common hematological malignancies worldwide. Among these, B-cell lymphomas (B-NHLs) are the second leading cause of death in hematologic neoplasms. In this study, a detailed immunophenotypic analysis of lymphocytes in the bone marrow aspirate (BMA) of 75 patients with four different subtypes of B-NHLs was performed at diagnosis. The samples were analyzed by flow cytometry (FC) using a stain-lyse-no wash technique and a comprehensive six-color antibody panel. Our data showed a different trend in the percentage values of the distinct lymphocyte subsets, which did not seem to correlate with a worse prognosis, except for B cells in diffuse large B-cell lymphoma (DLBCL), which were significantly higher in stage IV than in stages II and III. ROC curve analysis showed that the B-cell percentage value could be used to predict the stage of the disease. Total lymphocytes and B cells were greater in lymphomas that presented a lower percentage of disease progression, specifically mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL). In contrast, natural killer (NK) and T cells showed higher values in DLBCL and follicular lymphoma (FL), which progressed more frequently. Interestingly, in DLBCL patients with higher percentage values of double positive (DPT) and helper T cells (Th), we observed a good prognosis. Specifically, univariate Cox regression analyses indicated that a higher value of Th cells at diagnosis was a better prognostic predictor in patients with DLBCL. These preliminary findings encourage us to further investigate the role of lymphocyte subpopulations in B-cell NHL. This study provides a quick and inexpensive method for staging DLBCL by evaluating the percentage of CD19+ B lymphocytes using cytofluorimetry.In addition, the study showed that the evaluation of DPT and Th subsets can provide prognostic/predictive data, supporting their role in the immune response to cancer. This study provides a quick and inexpensive method for staging DLBCL by evaluating the percentage of CD19+ B lymphocytes using cytofluorimetry. In addition, the study showed that the evaluation of DPT and Th subsets can provide prognostic/predictive data, supporting their role in the immune response to cancer.
DOI: 10.6084/m9.figshare.30928073.v1
title: Prognostic relevance of bone marrow immune cell fractions in newly diagnosed B-cell non-Hodgkin lymphoma patients

description: Non-Hodgkin lymphomas (NHLs) are the most common hematological malignancies worldwide. Among these, B-cell lymphomas (B-NHLs) are the second leading cause of death in hematologic neoplasms. In this study, a detailed immunophenotypic analysis of lymphocytes in the bone marrow aspirate (BMA) of 75 patients with four different subtypes of B-NHLs was performed at diagnosis. The samples were analyzed by flow cytometry (FC) using a stain-lyse-no wash technique and a comprehensive six-color antibody panel. Our data showed a different trend in the percentage values of the distinct lymphocyte subsets, which did not seem to correlate with a worse prognosis, except for B cells in diffuse large B-cell lymphoma (DLBCL), which were significantly higher in stage IV than in stages II and III. ROC curve analysis showed that the B-cell percentage value could be used to predict the stage of the disease. Total lymphocytes and B cells were greater in lymphomas that presented a lower percentage of disease progression, specifically mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL). In contrast, natural killer (NK) and T cells showed higher values in DLBCL and follicular lymphoma (FL), which progressed more frequently. Interestingly, in DLBCL patients with higher percentage values of double positive (DPT) and helper T cells (Th), we observed a good prognosis. Specifically, univariate Cox regression analyses indicated that a higher value of Th cells at diagnosis was a better prognostic predictor in patients with DLBCL. These preliminary findings encourage us to further investigate the role of lymphocyte subpopulations in B-cell NHL. This study provides a quick and inexpensive method for staging DLBCL by evaluating the percentage of CD19+ B lymphocytes using cytofluorimetry.In addition, the study showed that the evaluation of DPT and Th subsets can provide prognostic/predictive data, supporting their role in the immune response to cancer. This study provides a quick and inexpensive method for staging DLBCL by evaluating the percentage of CD19+ B lymphocytes using cytofluorimetry. In addition, the study showed that the evaluation of DPT and Th subsets can provide prognostic/predictive data, supporting their role in the immune response to cancer.
DOI: 10.6084/m9.figshare.30928079
title: Care-seeking and treatment pathways of multidrug-resistant tuberculosis patients: an analysis of real-world data from regional health information system in Ningbo City in Eastern China

description: The patient pathway of multidrug-resistant tuberculosis (MDR-TB) in China is an essential but not well-studied area. This study aimed to understand the alignment between patient-initiated care-seeking demands for MDR-TB and the availability of diagnostic and treatment services in Ningbo, a city in eastern China, using patient pathway analysis (PPA). We collected the diagnostic and treatment data of 240 patients with MDR-TB in Ningbo from 2015 to 2019. Using patient pathway analysis, we matched the medical data of patients from different medical institutions and mapped their care pathways to illustrate their access to medical services. Our study indicated that the proportion of patients with MDR-TB who chose non-TB-designated medical institutions (55%) was higher than those who chose TB-designated medical institutions (45%) at their initial visit. An estimated 69% of patients with MDR-TB patients received initial TB screening services during their first visit. In this study, 47% of patients needed to visit 4–7 medical institutions to be diagnosed with MDR-TB. Overall, 80% (<i>n</i> = 192) of patients were diagnosed with MDR-TB within four visits, while 13% (<i>n</i> = 30), 4% (<i>n</i> = 10), and 3% (<i>n</i> = 8) of patients were not diagnosed at the fourth visit and remained at level 2, 1, and 0 medical institutions, respectively. The care-seeking pathway of patients with MDR-TB in Ningbo is complex. This indicates room for improvement in local diagnosis and referral services. There is a need to promote the deployment of MDR-TB screening, diagnosis, and treatment services at lower-level institutions.
DOI: 10.6084/m9.figshare.30928079.v1
title: Care-seeking and treatment pathways of multidrug-resistant tuberculosis patients: an analysis of real-world data from regional health information system in Ningbo City in Eastern China

description: The patient pathway of multidrug-resistant tuberculosis (MDR-TB) in China is an essential but not well-studied area. This study aimed to understand the alignment between patient-initiated care-seeking demands for MDR-TB and the availability of diagnostic and treatment services in Ningbo, a city in eastern China, using patient pathway analysis (PPA). We collected the diagnostic and treatment data of 240 patients with MDR-TB in Ningbo from 2015 to 2019. Using patient pathway analysis, we matched the medical data of patients from different medical institutions and mapped their care pathways to illustrate their access to medical services. Our study indicated that the proportion of patients with MDR-TB who chose non-TB-designated medical institutions (55%) was higher than those who chose TB-designated medical institutions (45%) at their initial visit. An estimated 69% of patients with MDR-TB patients received initial TB screening services during their first visit. In this study, 47% of patients needed to visit 4–7 medical institutions to be diagnosed with MDR-TB. Overall, 80% (<i>n</i> = 192) of patients were diagnosed with MDR-TB within four visits, while 13% (<i>n</i> = 30), 4% (<i>n</i> = 10), and 3% (<i>n</i> = 8) of patients were not diagnosed at the fourth visit and remained at level 2, 1, and 0 medical institutions, respectively. The care-seeking pathway of patients with MDR-TB in Ningbo is complex. This indicates room for improvement in local diagnosis and referral services. There is a need to promote the deployment of MDR-TB screening, diagnosis, and treatment services at lower-level institutions.
DOI: 10.15468/dl.wcst25
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003102-260120142942310/datasets/export for details.
DOI: 10.6084/m9.figshare.30049254
title: Effect of adequate calories and amino acids supplementation delivered via parenteral nutrition on muscle mass maintenance in patients with type I or II intestinal failure: a retrospective study

description: Muscle mass depletion caused by hypercatabolism and inappropriate nutritional support in patients with intestinal failure (IF) is associated with poor clinical outcomes and reduced quality of life. This retrospective study evaluated the correlation between nutritional support factors (type and composition) and muscle mass. In this cohort study, two hundreds and twenty-three eligible patients with type I or II IF were included at a clinical nutrition center between September 2013 and September 2017. Muscle mass was measured <i>via</i> Bioelectrical Impedance Analysis. Statistical analyses included paired-samples <i>T</i> test, Pearson’s or Spearman’s rank correlation, univariate and multivariate regressions. The mean age was 46.1 ± 18.6 years, the mean nutritional risk screening -2002 score was 3.5 ± 0.8, and the median hospitalization duration was 19.5 days. Multivariate linear regression analysis revealed that Δsoft lean mass (ΔSLM) and Δskeletal muscle mass (ΔSMM) were significantly correlated with calories delivered <i>via</i> parenteral nutrition (PN) (<i>β</i> = 0.051, 95%CI [0.014, 0.008], <i>p</i> &lt; 0.05 and <i>β</i> = 0.041, 95%CI [0.010, 0.072], <i>p</i> &lt; 0.05). Among the PN composition variables, daily glucose intake <i>via</i> PN showed a significant correlation with ΔSLM (<i>β</i> = 0.350, 95%CI [0.091, 0.609], <i>p</i> &lt; 0.01) and ΔSMM (<i>β</i> = 0.254, 95%CI [0.027, 0.481], <i>p</i> &lt; 0.01). Subgroup analysis revealed that daily glucose intake <i>via</i> PN was associated with ΔSMM, especially at ≥1.2 g/kg/day of amino acid intake (<i>r</i> = 0.328, <i>p</i> &lt; 0.01). Adequate calories and amino acids supplementation delivered <i>via</i> parenteral nutrition play an important role in promoting muscle mass maintenance in patients with type I or II intestinal failure, who were under metabolically unstable or enteral nutrition intolerance condition.
DOI: 10.6084/m9.figshare.30049254.v1
title: Effect of adequate calories and amino acids supplementation delivered via parenteral nutrition on muscle mass maintenance in patients with type I or II intestinal failure: a retrospective study

description: Muscle mass depletion caused by hypercatabolism and inappropriate nutritional support in patients with intestinal failure (IF) is associated with poor clinical outcomes and reduced quality of life. This retrospective study evaluated the correlation between nutritional support factors (type and composition) and muscle mass. In this cohort study, two hundreds and twenty-three eligible patients with type I or II IF were included at a clinical nutrition center between September 2013 and September 2017. Muscle mass was measured <i>via</i> Bioelectrical Impedance Analysis. Statistical analyses included paired-samples <i>T</i> test, Pearson’s or Spearman’s rank correlation, univariate and multivariate regressions. The mean age was 46.1 ± 18.6 years, the mean nutritional risk screening -2002 score was 3.5 ± 0.8, and the median hospitalization duration was 19.5 days. Multivariate linear regression analysis revealed that Δsoft lean mass (ΔSLM) and Δskeletal muscle mass (ΔSMM) were significantly correlated with calories delivered <i>via</i> parenteral nutrition (PN) (<i>β</i> = 0.051, 95%CI [0.014, 0.008], <i>p</i> &lt; 0.05 and <i>β</i> = 0.041, 95%CI [0.010, 0.072], <i>p</i> &lt; 0.05). Among the PN composition variables, daily glucose intake <i>via</i> PN showed a significant correlation with ΔSLM (<i>β</i> = 0.350, 95%CI [0.091, 0.609], <i>p</i> &lt; 0.01) and ΔSMM (<i>β</i> = 0.254, 95%CI [0.027, 0.481], <i>p</i> &lt; 0.01). Subgroup analysis revealed that daily glucose intake <i>via</i> PN was associated with ΔSMM, especially at ≥1.2 g/kg/day of amino acid intake (<i>r</i> = 0.328, <i>p</i> &lt; 0.01). Adequate calories and amino acids supplementation delivered <i>via</i> parenteral nutrition play an important role in promoting muscle mass maintenance in patients with type I or II intestinal failure, who were under metabolically unstable or enteral nutrition intolerance condition.
DOI: 10.6084/m9.figshare.29950162
title: The experience and needs of informal caregivers of people with dementia in rural Vietnam: a qualitative study

description: Caregivers of people with dementia living in rural areas face numerous challenges owing to the progressive nature of the disease, limited resources, and inadequate support services. Research on how caregivers experience dementia caregiving in Vietnam and similar Asian settings is limited. This study explored caregivers’ experiences, consequences, and caregiving needs in a rural district of Hanoi. We recruited 20 dyads (people with dementia and their caregivers) and eight health professionals. A qualitative study design using a semi-structured interview approach was employed. This study used a thematic analysis approach. Nine major themes were identified: (1) stepping into the caregiver role and responsibilities; (2) supporting activities of daily living; (3) managing behavioural problems; (4) complex care needs; (5) caregiver-related challenges; 6) healthcare-related challenges; (7) knowledge, perception, and awareness of caregivers; (8) consequences of caregiving; and (9) perceived needs. Thematic analyses revealed that the caregiving challenges of dementia caregivers were related to behavioral disturbance, functional care needs, complex care needs, caregiver-related challenges, healthcare-related challenges, understanding of dementia, and stepping into the caregiver role and responsibilities. The consequences of caregiving affect caregivers’ physical, psychological, and financial health. Understanding their experiences is essential for developing effective interventions to reduce caregiving burden and improve the quality of care.
DOI: 10.6084/m9.figshare.29950162.v1
title: The experience and needs of informal caregivers of people with dementia in rural Vietnam: a qualitative study

description: Caregivers of people with dementia living in rural areas face numerous challenges owing to the progressive nature of the disease, limited resources, and inadequate support services. Research on how caregivers experience dementia caregiving in Vietnam and similar Asian settings is limited. This study explored caregivers’ experiences, consequences, and caregiving needs in a rural district of Hanoi. We recruited 20 dyads (people with dementia and their caregivers) and eight health professionals. A qualitative study design using a semi-structured interview approach was employed. This study used a thematic analysis approach. Nine major themes were identified: (1) stepping into the caregiver role and responsibilities; (2) supporting activities of daily living; (3) managing behavioural problems; (4) complex care needs; (5) caregiver-related challenges; 6) healthcare-related challenges; (7) knowledge, perception, and awareness of caregivers; (8) consequences of caregiving; and (9) perceived needs. Thematic analyses revealed that the caregiving challenges of dementia caregivers were related to behavioral disturbance, functional care needs, complex care needs, caregiver-related challenges, healthcare-related challenges, understanding of dementia, and stepping into the caregiver role and responsibilities. The consequences of caregiving affect caregivers’ physical, psychological, and financial health. Understanding their experiences is essential for developing effective interventions to reduce caregiving burden and improve the quality of care.