cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17870/bathspa.8118584
title: danceroom Spectroscopy 2.0 - Performance and Installation at Zentrum für Kunst und Medien (ZKM) in Karlsruhe, Germany (2014)

description: danceroom Spectroscopy (dS) is an arts/science collaborative project exploring molecular dynamics, allowing users to interact with a scientifically-accurate molecular simulation through movement in real time. Hyde’s contribution is the sound and music for the project, involving a complex interactive system (for a public installation) and an hour long interactive score for a dance-based performance using the system.<br><br>This item contains photo documentation of a performance and installation at Zentrum für Kunst und Medien (ZKM) in Karlsruhe, Germany, 4-6 January 2014.<br><br><b>Photos by Joseph Hyde.</b><b>Used with permission.<br></b><b><br>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.8143538
title: danceroom Spectroscopy 2.0 - We the Curious Exhibition

description: danceroom Spectroscopy (dS) is an arts/science collaborative project exploring molecular dynamics, allowing users to interact with a scientifically-accurate molecular simulation through movement in real time. Hyde’s contribution is the sound and music for the project, involving a complex interactive system (for a public installation) and an hour long interactive score for a dance-based performance using the system.<br>This item documents an interactive exhibition of danceroom Spectroscopy held at We the Curious, in Bristol, UK.<br><b>Photos by Joseph Hyde.</b><b>Used with permission. </b><b><br></b><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law</b><br>
DOI: 10.17870/bathspa.8143538.v1
title: danceroom Spectroscopy 2.0 - We the Curious Exhibition

description: danceroom Spectroscopy (dS) is an arts/science collaborative project exploring molecular dynamics, allowing users to interact with a scientifically-accurate molecular simulation through movement in real time. Hyde’s contribution is the sound and music for the project, involving a complex interactive system (for a public installation) and an hour long interactive score for a dance-based performance using the system.<br>This item documents an interactive exhibition of danceroom Spectroscopy held at We the Curious, in Bristol, UK.<br><b>Photos by Joseph Hyde.</b><b>Used with permission. </b><b><br></b><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law</b><br>
DOI: 10.6084/m9.figshare.14264396
title: DATA Food provisioning in the Collared Flycatcher (Ficedula albicollis)

description: In bird species where offspring growth and survival rely on parents’ food provisioning, parents can maximise their fitness by increasing the quantity and/or the quality of preys delivered to their offspring. Many studies have focused on inter-individual variation in feeding rate, yet this measure may not accurately reflect the total amount of food (i.e. energy) provided by parents if there is large variation in the quantity and quality of preys at each feeding. Here, we explored the relative role of individual (sex, age, body condition), breeding (hatching date, brood size) and environmental (temperature) factors on feeding rate, prey number, size and quality, and their contribution to total prey biomass delivered to the nestlings of 164 Collared Flycatcher (Ficedula albicollis) parents in 98 nests. Preys delivered to the nest were mainly larvae (53.6%) and flying insects (45.6%). Feeding rate increased with brood size and age, and was higher in males than females. Mean prey number decreased, but mean prey size increased, as the season progressed and parents feeding their brood with primary larvae brought more preys per visit. Relationships between feeding rate, mean prey number and size remained when taking into account the provisioning quality: parents brought either a large number of small prey or a small number of larger items, and the force of the trade-offs between feeding rate and mean prey number and size depended on the quality of the provisioning of the parents. Whatever the percentage of larvae among preys in the provisioning, the variance in total prey biomass was foremost explained by feeding rate (65.1% to 76.6%) compared to mean prey number (16.4% to 26%) and prey size (2.7% to 4%). Our study shows that variation in feeding rate, prey number, size, but not quality (i.e. percentage of larvae), were influenced by individual factors (sex and age) and breeding decisions (brood size and timing of breeding) and that, whatever the provisioning strategy adopted, feeding rate was the best proxy of the total biomass delivered to the nestlings.<br>
DOI: 10.6084/m9.figshare.14153367
title: Multivariate analyses for investigating highly polluted marine ecosystem: The case study of Mar Piccolo (Taranto, South Italy)

description: This study presents the benefits of the application of multivariate techniques for the hazard assessment of a heavily polluted marine ecosystem. The study area, named Mar Piccolo, near Taranto city (Southern Italy), is a shallow marine basin located nearby an industrial compromised area, declared by the national government as Contaminated Site of Environmental Interest (SIN) due to the presence of long-lasting large industrial settlements that have severely impacted the marine environment. Besides the anthropogenic pressures, the marine basin is characterized by high productivity of several species at different trophic levels of the food chain, that confers to the bottom sediments an unusually high organic matter content. The latter is even enhanced by the presence of freshwater springs in the marine basin. The dynamism of the ecosystem demands for advanced evaluation tools for its correct characterisation. Multivariate ANOVA allied by Hierarchical Clustering are applied in this research to provide a readable picture of the quality status of the sediments, aiming at identifying different loading factors and getting insights into their simultaneous effects. The innovative approach adopted circumvents inefficient time-consuming procedures, usually required by the conventional univariate analyses of each parameter selected for sediment characterisation. A comprehensive hazard assessment was possible thanks to a clear graphical representation of the hazard distribution that supported the identification of the hazard controlling factors, confirming the efficiency of the adopted approach. The tools proposed herein can thus be recommended for the decision makers in investigating and interpretation of the quality status of complex polluted marine eco-systems.
DOI: 10.6084/m9.figshare.14153367.v1
title: Multivariate analyses for investigating highly polluted marine ecosystem: The case study of Mar Piccolo (Taranto, South Italy)

description: This study presents the benefits of the application of multivariate techniques for the hazard assessment of a heavily polluted marine ecosystem. The study area, named Mar Piccolo, near Taranto city (Southern Italy), is a shallow marine basin located nearby an industrial compromised area, declared by the national government as Contaminated Site of Environmental Interest (SIN) due to the presence of long-lasting large industrial settlements that have severely impacted the marine environment. Besides the anthropogenic pressures, the marine basin is characterized by high productivity of several species at different trophic levels of the food chain, that confers to the bottom sediments an unusually high organic matter content. The latter is even enhanced by the presence of freshwater springs in the marine basin. The dynamism of the ecosystem demands for advanced evaluation tools for its correct characterisation. Multivariate ANOVA allied by Hierarchical Clustering are applied in this research to provide a readable picture of the quality status of the sediments, aiming at identifying different loading factors and getting insights into their simultaneous effects. The innovative approach adopted circumvents inefficient time-consuming procedures, usually required by the conventional univariate analyses of each parameter selected for sediment characterisation. A comprehensive hazard assessment was possible thanks to a clear graphical representation of the hazard distribution that supported the identification of the hazard controlling factors, confirming the efficiency of the adopted approach. The tools proposed herein can thus be recommended for the decision makers in investigating and interpretation of the quality status of complex polluted marine eco-systems.
DOI: 10.6084/m9.figshare.14264396.v1
title: DATA Food provisioning in the Collared Flycatcher (Ficedula albicollis)

description: In bird species where offspring growth and survival rely on parents’ food provisioning, parents can maximise their fitness by increasing the quantity and/or the quality of preys delivered to their offspring. Many studies have focused on inter-individual variation in feeding rate, yet this measure may not accurately reflect the total amount of food (i.e. energy) provided by parents if there is large variation in the quantity and quality of preys at each feeding. Here, we explored the relative role of individual (sex, age, body condition), breeding (hatching date, brood size) and environmental (temperature) factors on feeding rate, prey number, size and quality, and their contribution to total prey biomass delivered to the nestlings of 164 Collared Flycatcher (Ficedula albicollis) parents in 98 nests. Preys delivered to the nest were mainly larvae (53.6%) and flying insects (45.6%). Feeding rate increased with brood size and age, and was higher in males than females. Mean prey number decreased, but mean prey size increased, as the season progressed and parents feeding their brood with primary larvae brought more preys per visit. Relationships between feeding rate, mean prey number and size remained when taking into account the provisioning quality: parents brought either a large number of small prey or a small number of larger items, and the force of the trade-offs between feeding rate and mean prey number and size depended on the quality of the provisioning of the parents. Whatever the percentage of larvae among preys in the provisioning, the variance in total prey biomass was foremost explained by feeding rate (65.1% to 76.6%) compared to mean prey number (16.4% to 26%) and prey size (2.7% to 4%). Our study shows that variation in feeding rate, prey number, size, but not quality (i.e. percentage of larvae), were influenced by individual factors (sex and age) and breeding decisions (brood size and timing of breeding) and that, whatever the provisioning strategy adopted, feeding rate was the best proxy of the total biomass delivered to the nestlings.<br>
DOI: 10.6084/m9.figshare.14264601
title: Creation and validation of a citywide pediatric asthma registry for the District of Columbia

description: To create and validate a citywide pediatric Asthma Registry to improve the care and outcomes of children and adolescents in Washington, DC through data-driven quality improvement (QI). All available electronic health record data from inpatient and outpatient domains of Children’s National Hospital were aggregated from an existing enterprise data warehouse. Inclusion criteria included asthma relevant ICD-10 codes over the prior 24 months. Available Asthma Registry measures include patient demographics, ambulatory visits, hospital admissions, persistent asthma diagnoses, and prescription of controller medications. Data capture was validated using US Census data and current asthma prevalence estimate of the Behavioral Risk Factor Surveillance System (BRFSS). The registry identified 15,991 DC children and adolescents with asthma aged 0–17 years, inclusive, at the end of 2020. This was 14.2% higher than the estimate of 14,001 children derived from BRFSS. Characteristics of those in the registry included: mean age of 9.5 (1.4) years, 57.9% male, 72.3% Black, and 66.7% publicly insured. Over the prior 24 months, 30.3% had ≥1 emergency department visit, and 10.5% had ≥1 hospital admission. Controller medications were prescribed for 59.6% of children with persistent asthma. Rates varied by sampled primary care practice sites. A population-level pediatric asthma registry captures more children and adolescents with asthma in DC then a BRFSS-derived estimate, and provides city-wide measures of asthma-related utilization. The registry allows for stratification by primary care practice locations and asthma characteristics, supporting the design, implementation, and evaluation of QI projects at the practice, health system, and population levels. Supplemental data for this article can be accessed at publisher’s website.
DOI: 10.6084/m9.figshare.14264601.v1
title: Creation and validation of a citywide pediatric asthma registry for the District of Columbia

description: To create and validate a citywide pediatric Asthma Registry to improve the care and outcomes of children and adolescents in Washington, DC through data-driven quality improvement (QI). All available electronic health record data from inpatient and outpatient domains of Children’s National Hospital were aggregated from an existing enterprise data warehouse. Inclusion criteria included asthma relevant ICD-10 codes over the prior 24 months. Available Asthma Registry measures include patient demographics, ambulatory visits, hospital admissions, persistent asthma diagnoses, and prescription of controller medications. Data capture was validated using US Census data and current asthma prevalence estimate of the Behavioral Risk Factor Surveillance System (BRFSS). The registry identified 15,991 DC children and adolescents with asthma aged 0–17 years, inclusive, at the end of 2020. This was 14.2% higher than the estimate of 14,001 children derived from BRFSS. Characteristics of those in the registry included: mean age of 9.5 (1.4) years, 57.9% male, 72.3% Black, and 66.7% publicly insured. Over the prior 24 months, 30.3% had ≥1 emergency department visit, and 10.5% had ≥1 hospital admission. Controller medications were prescribed for 59.6% of children with persistent asthma. Rates varied by sampled primary care practice sites. A population-level pediatric asthma registry captures more children and adolescents with asthma in DC then a BRFSS-derived estimate, and provides city-wide measures of asthma-related utilization. The registry allows for stratification by primary care practice locations and asthma characteristics, supporting the design, implementation, and evaluation of QI projects at the practice, health system, and population levels. Supplemental data for this article can be accessed at publisher’s website.
DOI: 10.6084/m9.figshare.14071342
title: Synthesis and biological activity evaluation of some new mixed azines appended tetrahydro-1,2,4-triazines

description: A series of 6-acetyl-2,4-diaryl-2,3,4,5-tetrahydro-1,2,4-triazines (<b>2a–2f</b>) was synthesized by double Mannich reaction of the hydrazone <b>1a</b> or <b>1b</b> with formaldehyde and the appropriate amine. A similar reaction of <b>1a</b> with the appropriate diamine afforded the <i>bis</i>(tetrahydro-triazines) <b>3a–b</b>, and <b>4a–b</b>. Whereas, the 6-cinnamoyl derivatives <b>5a</b>-<b>c</b> were obtained by the reaction of <b>2a</b> with the appropriate aldehyde. The hydrazone <b>7</b>, derived from <b>2a</b>, was treated with the appropriate aldehyde or ketone to afford the mixed azines <b>8–12</b> and <b>13–16</b>. The biological activity, antibacterial, antifungal and antioxidants of the most newly synthesized compounds of these derivatives were screened. Compounds <b>2b</b>, <b>3a</b> and <b>7</b> revealed the best results against all screened biological activity
DOI: 10.6084/m9.figshare.14071342.v1
title: Synthesis and biological activity evaluation of some new mixed azines appended tetrahydro-1,2,4-triazines

description: A series of 6-acetyl-2,4-diaryl-2,3,4,5-tetrahydro-1,2,4-triazines (<b>2a–2f</b>) was synthesized by double Mannich reaction of the hydrazone <b>1a</b> or <b>1b</b> with formaldehyde and the appropriate amine. A similar reaction of <b>1a</b> with the appropriate diamine afforded the <i>bis</i>(tetrahydro-triazines) <b>3a–b</b>, and <b>4a–b</b>. Whereas, the 6-cinnamoyl derivatives <b>5a</b>-<b>c</b> were obtained by the reaction of <b>2a</b> with the appropriate aldehyde. The hydrazone <b>7</b>, derived from <b>2a</b>, was treated with the appropriate aldehyde or ketone to afford the mixed azines <b>8–12</b> and <b>13–16</b>. The biological activity, antibacterial, antifungal and antioxidants of the most newly synthesized compounds of these derivatives were screened. Compounds <b>2b</b>, <b>3a</b> and <b>7</b> revealed the best results against all screened biological activity
DOI: 10.6084/m9.figshare.13920708.v1
title: Reactivity of 5-phenyl-3-[(2-chloroquinolin-3-yl)methylene] furan-2(3<i>H</i>)-one towards hydrazine and benzylamine: A comparative study

description: The reactivity of a 2-chloroquinolinylfuranone derivative <b>3</b> was investigated against two nitrogen nucleophilic reagents namely, hydrazine and benzylamine. It was found that the regioselectivity of the reaction products was mainly dependent on the nature of nucleophiles, reaction conditions, and solvent used. Therefore, hydrazinolysis of <b>3</b> afforded the corresponding acid hydrazide and pyridazinone derivatives depending on the reaction conditions. Otherwise, benzylamine reacted with <b>3</b> at different reaction aspects to provide <i>N</i>-benzylamide, <i>N</i>-benzylpyrrolone, and 2-benzylaminoquinolinyl-<i>N</i>-benzylpyrrolone derivatives. The chemical structures of all synthesized compounds were substantiated from their analytical as well as spectroscopic data. Based on the charge density calculations and computational chemical study which excluded the aza-Michael addition reaction and confirm the higher electron-deficiency of lactone carbonyl group than C2-quinoline position, it can be concluded that the C2-furanone becomes more susceptible to attack by the nucleophilic reagent, hydrazine and benzylamine.
DOI: 10.6084/m9.figshare.13920708
title: Reactivity of 5-phenyl-3-[(2-chloroquinolin-3-yl)methylene] furan-2(3<i>H</i>)-one towards hydrazine and benzylamine: A comparative study

description: The reactivity of a 2-chloroquinolinylfuranone derivative <b>3</b> was investigated against two nitrogen nucleophilic reagents namely, hydrazine and benzylamine. It was found that the regioselectivity of the reaction products was mainly dependent on the nature of nucleophiles, reaction conditions, and solvent used. Therefore, hydrazinolysis of <b>3</b> afforded the corresponding acid hydrazide and pyridazinone derivatives depending on the reaction conditions. Otherwise, benzylamine reacted with <b>3</b> at different reaction aspects to provide <i>N</i>-benzylamide, <i>N</i>-benzylpyrrolone, and 2-benzylaminoquinolinyl-<i>N</i>-benzylpyrrolone derivatives. The chemical structures of all synthesized compounds were substantiated from their analytical as well as spectroscopic data. Based on the charge density calculations and computational chemical study which excluded the aza-Michael addition reaction and confirm the higher electron-deficiency of lactone carbonyl group than C2-quinoline position, it can be concluded that the C2-furanone becomes more susceptible to attack by the nucleophilic reagent, hydrazine and benzylamine.
DOI: 10.6084/m9.figshare.14264607.v1
title: Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on <i>BCR-ABL1</i>-like subtype

description: <i>BCR-ABL1</i>-like acute lymphoblastic leukemia (ALL) is a high-risk disease with a complex genomic background. Though extensively studied, data on the frequency and mutual associations of present mutations are still incomplete in adult patients. This retrospective study aims to map the genomic landscape of B-other ALL in a cohort of adult patients with a focus on the <i>BCR-ABL1</i>-like ALL subtype. We analyzed bone marrow and peripheral blood samples of adult B-other ALL patients treated consecutively at three major Czech teaching hospitals. Samples were analyzed by cytogenetic methods, gene expression profiling, multiplex ligation-dependent probe amplification (MLPA), and next-generation sequencing (NGS). Fifty-eight B-other ALL patients (not <i>BCR-ABL1</i>, <i>KMT2A</i>-rearranged, <i>ETV6-RUNX1</i>, <i>TCF3-PBX1</i>, or iAMP21) were included in the study. Median follow-up was 23.8 months. Samples from 33 patients were available for a gene expression analysis, 48.9% identified as <i>BCR-ABL1</i>-like ALL. Of the <i>BCR-ABL1</i>-like ALL cases, 18.8% harbored <i>IGH-CRLF2</i> and 12.5% <i>P2RY8-CRLF2</i> fusion gene. We observed a higher MRD failure rate in <i>BCR-ABL1</i>-like than in non-<i>BCR-ABL1</i>-like ALL patients after the induction treatment (50.0 vs. 13.3%, <i>p</i>=.05). There was a trend to worse progression-free and overall survival in the <i>BCR-ABL1</i>-like group, though not statistically significant. Deletions in <i>IKZF1</i> gene were found in 31.3% of <i>BCR-ABL1</i>-like cases. Patients with concurrent <i>IKZF1</i> and <i>CDKN2A/B, PAX5</i> or PAR1 region deletions (<i>IKZF1</i><sup>plus</sup> profile) had significantly worse progression-free survival than those with sole <i>IKZF1</i> deletion or <i>IKZF1</i> wild-type (<i>p</i>=.02). NGS analysis was performed in 54 patients and identified 99 short variants in <i>TP53, JAK2, NRAS, PAX5, CREBBP, NF1, FLT3, ATM, KRAS, RUNX1</i>, and other genes. Seventy-five of these gene variants have not yet been described in B-cell precursor ALL to date. This study widens existing knowledge of the <i>BCR-ABL1</i>-like and B-other ALL genomic landscape in the adult population, supports previous findings, and identifies a number of novel gene variants.