DOI: 10.5061/dryad.bvq83bk88
title: Data from: A concise review on antimicrobial peptides for prevention and treatment of dental caries

description: Antimicrobial peptides have become promising candidates for the
 development of antimicrobial therapeutics. This paper describes the
 collection and analysis of data performed for a published concise review
 on the application of antimicrobial peptides for the management of dental
 caries. A literature search was performed to locate journal articles
 published in the English language up to 2019. The search was performed
 through six common databases. The search term was (Antimicrobial peptide
 OR AMP OR Cathelicidin OR Defensin OR Histatin OR Statherin) AND (Caries
 OR Dental caries). A total of 4,392 journal articles were identified and
 956 duplicated articles were removed. Two investigators performed a
 screening of titles and abstracts of the articles. They excluded 3,364
 articles which were literature reviews or studies were unrelated to
 antimicrobial peptides or dental caries. The search finally included 67
 articles for analysis. The results of the search show the antibacterial
 properties of natural antimicrobial peptides against Streptococcus mutans.
 The anti-microbial peptides synthesized by researchers could inhibit
 bacteria, especially against Streptococcus mutans. This dataset lists and
 summarise the data from published studies regarding to antimicrobial
 peptides for management of dental caries. The dataset provides
 comprehensive knowledge on antimicrobial peptides as a bactericidal and
 remineralising reagent for the management of dental caries.
description: The literature search was performed by two independent
 investigators (NJY and YIX) to identify articles in English from
 establishment to 2019 including advanced online articles. The search was
 performed in four common databases on the subjects of dentistry, oral
 surgery and medicine: Embase, PubMed, Scopus and ISI Web of Science. In
 addition, the paper also searched two databases targeting for the archive
 of literature of antimicrobial peptides, namely Collection of
 Anti-Microbial Peptides and the Antimicrobial Peptide Database. The search
 term was (Antimicrobial peptide OR AMP OR Cathelicidin OR Defensin OR
 Histatin OR Statherin) AND (Caries OR Dental caries). Full search
 strategies were as follows: PubMed, (‘Antimicrobial peptide’ OR ‘AMP’ OR
 ‘Cathelicidin’ OR ‘Defensin’ OR ‘Histatin’ OR ‘Statherin’) AND (‘Caries’
 OR ‘Dental caries’); Web of Science, TOPIC: ((‘Antimicrobial peptide’ OR
 ‘AMP’ OR ‘Cathelicidin’ OR ‘Defensin’ OR ‘Histatin’ OR ‘Statherin’) AND
 (‘Caries’ OR ‘Dental caries’)) Timespan: All years. Indexes: SCI-EXPANDED,
 SSCI, A&HCI, CPCI-S, CPCI-SSH, ESCI.; Embase, ((Antimicrobial
 peptide or AMP or Cathelicidin or Defensin or Histatin or Statherin) and
 (Caries or Dental caries)).mp. [mp=title, abstract, heading word, drug
 trade name, original title, device manufacturer, drug manufacturer, device
 trade name, keyword, floating subheading word, candidate term word];
 Scopus, ALL ((antimicrobial AND peptide OR amp OR cathelicidin OR defensin
 OR histatin OR statherin) AND (caries OR dental AND caries )). The last
 search for this paper was conducted on 31 January 2020.
description: This
 dataset combines the results from previous studies regarding to
 antimicrobial peptides for management of dental caries. The dataset shows
 the antibacterial properties of natural antimicrobial peptides against
 <i>Streptococcus mutans</i>. In addition, the antimicrobial
 peptides synthesized by researchers could inhibit bacteria, especially
 against <i>Streptococcus mutans</i>. Some of antimicrobial
 peptides could prevent bacteria from adhering to tooth surface, whereas
 some of them displayed remineralising properties on
 hydroxyapatite. No
 previous review has evaluated the current status and prospects of
 antimicrobial peptides for managing dental caries. This dataset provides a
 comprehensive summary on using antimicrobial peptides as a promising
 reagent to prevent and treat dental caries. Hence, these data could be
 useful to researchers interested in development of novel anti-caries
 medication. The
 method of data collection was through a systematic search of the six
 databases. Clinical studies and studies of different designs were
 included. Therefore, the methods described and the data contained in this
 paper may be useful for future research on the application of
 antimicrobial peptides in management of dental caries in
 clinics. This
 dataset provides comprehensive knowledge on antimicrobial peptides as an
 bactericidal and remineralising reagent for the management of dental
 caries. <b>Table 1.
 </b>Types of<b> </b>antimicrobial peptides for
 prevention and treatment of dental caries <b>Table 2.
 </b>List of antimicrobial peptides
 and authors and year of the
 publications <b>Table 3.
 </b>Abbreviation list  <strong>Bibliography.
 </strong>The list of 67 articles remained for data
 analysis