cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14279862
title: Reduction of prefrontal thickness in military police officers with post-traumatic stress disorder

description: Abstract Background Brain-imaging studies in post-traumatic stress disorder (PTSD) have consistently revealed alterations in brain structure and function and this is correlated to symptomatology. However, few studies have investigated the role of biomarkers in PTSD some specific groups, as police officers. Objective To evaluate prefrontal and limbic volumes, and cortical thickness of police officers exposed to trauma during work who developed post-traumatic stress disorder, resilient matched controls (without PTSD), and compared to healthy civilians. Methods Prefrontal and limbic volumes, and cortical thickness of 12 police officers with PTSD, 12 resilient police officers, and 12 healthy civilians who underwent brain MRI were analyzed. Results Differences in limbic structures volume were not significative after Bonferroni correction. A significant reduction in cortical thickness on right rostral cingulate, right and left middle frontal gyrus, left superior frontal, left lingual, calcarine and cuneus were observed in PTSD group in comparison to controls was observed. Discussion Although preliminary, our results suggested not only the association between cortical thickness and PTSD, but also indicated that patients and controls have anatomical differences.
DOI: 10.6084/m9.figshare.14279859
title: Mediating role of childhood abuse for the relationship between schizotypal traits and obsessive-compulsive disorder

description: Abstract Background The mediating role of childhood trauma in the relationship between schizotypal symptoms and obsessive-compulsive disorder (OCD) was not sufficiently investigated to date. Objectives In the present study, our major goal was to analyse the mediator role of childhood abuse (emotional, physical, and sexual), and neglect (emotional and physical) on the link between schizotypal symptoms and OCD, after controlling for duration of OCD, the mean number of comorbid Axis I disorders, and current anxiety. Methods One hundred fifteen patients (aged 18-65 years) who had primary diagnosis of OCD and Yale-Brown Obsessive-Compulsive Scale score ≥16 were assessed using the short form of Childhood Trauma Questionnaire questionnaire (CTQ-SF), Schizotypal Personality Questionnaire (SPQ), and Beck Anxiety Inventory (BAI). Results The all types of schizotypal symptoms were significantly correlated with the scores of childhood abuse and neglect, and BAI. The childhood abuse as a mediator significantly predicted the total YBOCS scores (p = 0.02) after when BAI scores were controlled. However, childhood neglect was not multivariately related to current OCD severity, and did not mediate the relationship between schizotypal traits and total YBOCS scores. Discussion We suggested that childhood trauma mediated the schizotypal traits in relationship with current OCD severity independent from anxiety severity.
DOI: 10.6084/m9.figshare.14279862.v1
title: Reduction of prefrontal thickness in military police officers with post-traumatic stress disorder

description: Abstract Background Brain-imaging studies in post-traumatic stress disorder (PTSD) have consistently revealed alterations in brain structure and function and this is correlated to symptomatology. However, few studies have investigated the role of biomarkers in PTSD some specific groups, as police officers. Objective To evaluate prefrontal and limbic volumes, and cortical thickness of police officers exposed to trauma during work who developed post-traumatic stress disorder, resilient matched controls (without PTSD), and compared to healthy civilians. Methods Prefrontal and limbic volumes, and cortical thickness of 12 police officers with PTSD, 12 resilient police officers, and 12 healthy civilians who underwent brain MRI were analyzed. Results Differences in limbic structures volume were not significative after Bonferroni correction. A significant reduction in cortical thickness on right rostral cingulate, right and left middle frontal gyrus, left superior frontal, left lingual, calcarine and cuneus were observed in PTSD group in comparison to controls was observed. Discussion Although preliminary, our results suggested not only the association between cortical thickness and PTSD, but also indicated that patients and controls have anatomical differences.
DOI: 10.6084/m9.figshare.14279864
title: Using data from schizophrenia outcome study to estimate the time to treatment outcome and the early-response cut-off score that predicts outcome at week 16

description: Abstract Background Being able to make an estimation of the time to clinical outcome, and making predictions early during treatment about the possibility of later response/non-response to treatment, is an important asset that can help to guide treatment strategies and counsel patients and caregivers about treatment expectations. Objectives The study aimed to determine the time course to treatment outcome and the psychopathological cut-off score at week 4 that predicts outcome at week 16. Methods This was a naturalistic follow-up study of 160 incident cases of schizophrenia over 16 weeks. Four intervals of follow-up clinical assessments were done. Standard criteria for response and remission were applied. Results The mean (median) times, in weeks, to response and remission using Brief Psychiatric Rating Scale (BPRS) data were 8.1(8.0); 8.4(8.0); and 10.9 (12.0), respectively. The Areas Under the Curves were high, for response (0.909; 95% C.I., 0.85-0.97) and remission (0.86; 95% C.I., 0.81 -0.94) at week 16. A cut-off score of 20.7% reduction in the total BPRS score at week 4, predicted response status (79.5% sensitivity, 84.2% specificity) and remission status (77.6% sensitivity, 73.3% specificity) at week 16. In addition, a cut-off of 10.21% reduction in the total Scale for Assessment of Negative Symptoms (SANS) score at week 4, predicted response (70.8% sensitivity, 95.5% specificity) at week 16. Discussion The results are in line with the general clinical impression that, by 2 months, most acutely ill inpatients are fit for discharge; and introduced for further investigation 10.21% reduction in SANS Score as a marker of treatment resistance in schizophrenia.
DOI: 10.6084/m9.figshare.14279864.v1
title: Using data from schizophrenia outcome study to estimate the time to treatment outcome and the early-response cut-off score that predicts outcome at week 16

description: Abstract Background Being able to make an estimation of the time to clinical outcome, and making predictions early during treatment about the possibility of later response/non-response to treatment, is an important asset that can help to guide treatment strategies and counsel patients and caregivers about treatment expectations. Objectives The study aimed to determine the time course to treatment outcome and the psychopathological cut-off score at week 4 that predicts outcome at week 16. Methods This was a naturalistic follow-up study of 160 incident cases of schizophrenia over 16 weeks. Four intervals of follow-up clinical assessments were done. Standard criteria for response and remission were applied. Results The mean (median) times, in weeks, to response and remission using Brief Psychiatric Rating Scale (BPRS) data were 8.1(8.0); 8.4(8.0); and 10.9 (12.0), respectively. The Areas Under the Curves were high, for response (0.909; 95% C.I., 0.85-0.97) and remission (0.86; 95% C.I., 0.81 -0.94) at week 16. A cut-off score of 20.7% reduction in the total BPRS score at week 4, predicted response status (79.5% sensitivity, 84.2% specificity) and remission status (77.6% sensitivity, 73.3% specificity) at week 16. In addition, a cut-off of 10.21% reduction in the total Scale for Assessment of Negative Symptoms (SANS) score at week 4, predicted response (70.8% sensitivity, 95.5% specificity) at week 16. Discussion The results are in line with the general clinical impression that, by 2 months, most acutely ill inpatients are fit for discharge; and introduced for further investigation 10.21% reduction in SANS Score as a marker of treatment resistance in schizophrenia.
DOI: 10.6084/m9.figshare.14279865
title: G protein gene variants in schizophrenia

description: Abstract Background Various studies demonstrating enhanced vulnerability to apoptosis may contribute to the pathobiology of schizophrenia. Objective Thus, G proteins may provide an intriguing link between the signal transduction, and apoptotic hypotheses of schizophrenia. In the light of these findings, we investigated whether G protein gene polymorphisms (GNAS1-T393C and GNB3-C825T) accounted for an increased risk of schizophrenia. Methods The present analyses were based on 100 subjects diagnosed with schizophrenia, and on 100 unrelated healthy controls. The genotyping of GNAS1-T393C, and GNB3-C825T gene polymorphisms were performed using the polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). Results: We demonstrated the positive association of GNB3-C825T gene variants with schizophrenia risk (p: 0.023). In our study, more prevalent CC genotype frequencies were detected in GNB3 in patients compared with the frequencies in the controls. The individuals with GNB3-C825T CC genotype had 2 fold increased risk for schizophrenia (p: 0.011, c2: 6.39, OR:2.14, 95% CI: 1.18-3.90). Discussion Our study results suggested that GNB3-C825T polymorphism might be associated with schizophrenia.
DOI: 10.6084/m9.figshare.14268723
title: Depression, PTSD and alexithymia in victims of intimate partner violence: a case-control study

description: Abstract Background Intimate partner violence (IPV) regards millions of women worldwide and can lead to serious psychopathological consequences. Objective We aimed to evaluate differences between a group of abused women and controls, and potential predictors of depression and PTSD in the IPV group. Methods We recruited 57 women who experienced IPV and 57 age-matched controls from the general population. After collecting socio-demographic characteristics, we administered the following scales: Hamilton Depression Rating Scale (HDRS), Davidson Trauma Scale (DTS), Toronto Alexithymia Scale (TAS-20) and Revised-Conflict Tactics Scale (CTS-2). Results Our results showed differences between women who experienced IPV and controls in the socio-economic status, employment and educational levels, childhood abuse and early terminations of pregnancy. Notably, the rates of depression, PTSD, and alexithymia were significantly different between the two groups. Linear regression models revealed that sexual coercion was an independent positive predictor of depressive symptoms, while alexithymia played a role in the development of PTSD in the group of abused women. Discussion Given the prevalence of depression and PTSD in victims of IPV, it is important to always investigate for IPV in women seeking for help in mental health services. Alexithymia in victims of IPV deserves to be further investigated by researchers.
DOI: 10.6084/m9.figshare.14279868
title: Correlates of neuropsychiatric and motor tests with language assessment in patients with Lewy body dementia

description: Abstract Background Lewy body dementia (LBD) impairs performance in daily activities and affects motor, language and visuospatial tasks. Objective We aimed to correlate neuropsychiatric and motor assessments with language and visual organization tests in LBD. Methods Twenty-two patients with dementia with Lewy bodies and ten patients with Parkinson’s disease dementia participated on a cross-sectional study that assessed cognition, functionality, caregiver burden, verbal fluency, the primer-level dictation section of the Boston Diagnostic Aphasia Examination (PLD-BDAE), the Hooper Visual Organization Test, the Neuropsychiatric Inventory and the Movement Disorder Society – Unified Parkinson’s Disease Rating Scale. Results Language and visuospatial test results followed motor impairment and general cognitive performance. Whereas visual organization did not predict performance in the PLD-BDAE, visuospatial abilities and verbal fluency were concurrently associated, suggesting that linguistic impairment in LBD may be attributed to neuropsychological components of cognition and language. Only visual organization was associated with behaviour, suggesting that neuropsychiatric symptoms associate with differential impairment of visual organization in comparison with language in LBD. Schooling did not affect visual organization or language test performance, while the length of dementia was negatively associated with visual organization and verbal fluency. Discussion Though visual organization tests follow behaviour and motor performance in LBD, there is differential impairment regarding language skills.
DOI: 10.6084/m9.figshare.14279868.v1
title: Correlates of neuropsychiatric and motor tests with language assessment in patients with Lewy body dementia

description: Abstract Background Lewy body dementia (LBD) impairs performance in daily activities and affects motor, language and visuospatial tasks. Objective We aimed to correlate neuropsychiatric and motor assessments with language and visual organization tests in LBD. Methods Twenty-two patients with dementia with Lewy bodies and ten patients with Parkinson’s disease dementia participated on a cross-sectional study that assessed cognition, functionality, caregiver burden, verbal fluency, the primer-level dictation section of the Boston Diagnostic Aphasia Examination (PLD-BDAE), the Hooper Visual Organization Test, the Neuropsychiatric Inventory and the Movement Disorder Society – Unified Parkinson’s Disease Rating Scale. Results Language and visuospatial test results followed motor impairment and general cognitive performance. Whereas visual organization did not predict performance in the PLD-BDAE, visuospatial abilities and verbal fluency were concurrently associated, suggesting that linguistic impairment in LBD may be attributed to neuropsychological components of cognition and language. Only visual organization was associated with behaviour, suggesting that neuropsychiatric symptoms associate with differential impairment of visual organization in comparison with language in LBD. Schooling did not affect visual organization or language test performance, while the length of dementia was negatively associated with visual organization and verbal fluency. Discussion Though visual organization tests follow behaviour and motor performance in LBD, there is differential impairment regarding language skills.
DOI: 10.5281/zenodo.5819181
title: COVID-19 and panic disorder: clinical considerations for the most physical of mental disorders

description: COVID-19 and panic<br> disorder: clinical<br> considerations for the most<br> physical of mental<br> disorders
DOI: 10.5281/zenodo.5819168
title: Halcyon smyrnensis decontaminated FSCR

description: .
DOI: 10.5281/zenodo.5819167
title: Halcyon smyrnensis decontaminated FSCR

description: .
DOI: 10.5281/zenodo.5819184
title: 'Precision' or 'personalized' psychiatry: different terms – same content?

description: ‘Precision’ or ‘personalized’ psychiatry: different terms – same<br> content? Due to the increased lifetime prevalence and personal,<br> social, and economic burden of mental disorders, psychiatry<br> is in need of a significant change in several aspects of<br> its clinical and research approaches. Over the last few<br> decades, the development of personalized / precision medicine in psychiatry focusing on tailored therapies that<br> fit each patient’s unique individual, physiological, and<br> genetic profile has not achieved the same results as those<br> obtained in other branches, such as oncology. The longawaited<br> revolution has not yet surfaced. There are various<br> explanations for this including imprecise diagnostic criteria,<br> incomplete understanding of the molecular pathology<br> involved, absence of available clinical tools and, finally, the<br> characteristics of the patient. Since then, the co-existence<br> of the two terms has sparked a great deal of discussion<br> around the definition and differentiation between the two<br> types of psychiatry, as they often seem similar or even<br> superimposable. Generally, the two terminologies are used<br> indiscriminately, alternatively, and / or separately, within<br> the same scientific works. In this paper, an overview is<br> provided on the overlap between the application and<br> meaning of the terms ‘precision psychiatry’ and ‘personalized<br> psychiatry’.
DOI: 10.5281/zenodo.5819183
title: 'Precision' or 'personalized' psychiatry: different terms – same content?

description: ‘Precision’ or ‘personalized’ psychiatry: different terms – same<br> content? Due to the increased lifetime prevalence and personal,<br> social, and economic burden of mental disorders, psychiatry<br> is in need of a significant change in several aspects of<br> its clinical and research approaches. Over the last few<br> decades, the development of personalized / precision medicine in psychiatry focusing on tailored therapies that<br> fit each patient’s unique individual, physiological, and<br> genetic profile has not achieved the same results as those<br> obtained in other branches, such as oncology. The longawaited<br> revolution has not yet surfaced. There are various<br> explanations for this including imprecise diagnostic criteria,<br> incomplete understanding of the molecular pathology<br> involved, absence of available clinical tools and, finally, the<br> characteristics of the patient. Since then, the co-existence<br> of the two terms has sparked a great deal of discussion<br> around the definition and differentiation between the two<br> types of psychiatry, as they often seem similar or even<br> superimposable. Generally, the two terminologies are used<br> indiscriminately, alternatively, and / or separately, within<br> the same scientific works. In this paper, an overview is<br> provided on the overlap between the application and<br> meaning of the terms ‘precision psychiatry’ and ‘personalized<br> psychiatry’.
DOI: 10.6084/m9.figshare.17868707
title: Covid19Research_Data set final.sav

description: The data and materials that support the results or analyses of the study. A cross-sectional quantitative approach was adopted for the study. A convenient sample of 1119 undergraduate students from two universities in the Volta Region of Ghana completed self-administered questionnaires following the appropriate ethical approval. The data were analyzed using descriptive statistics, Kruskal Wallis and Mann Whitney <i>U</i>-tests drawing on IBM Statistical Package for Social Sciences version 25.0.<br>
DOI: 10.6084/m9.figshare.17868707.v1
title: Covid19Research_Data set final.sav

description: The data and materials that support the results or analyses of the study. A cross-sectional quantitative approach was adopted for the study. A convenient sample of 1119 undergraduate students from two universities in the Volta Region of Ghana completed self-administered questionnaires following the appropriate ethical approval. The data were analyzed using descriptive statistics, Kruskal Wallis and Mann Whitney <i>U</i>-tests drawing on IBM Statistical Package for Social Sciences version 25.0.<br>
DOI: 10.5281/zenodo.5819191
title: Human recreation impacts seasonal activity and occupancy of American black bears (Ursus americanus) across the urban-wildlife interface

description: The datasets used for all analyses throughout the study that are downloaded from the Yooper Wildlife Watch Project found on Zooniverse.
DOI: 10.5281/zenodo.5819190
title: Human recreation impacts seasonal activity and occupancy of American black bears (Ursus americanus) across the urban-wildlife interface

description: The datasets used for all analyses throughout the study that are downloaded from the Yooper Wildlife Watch Project found on Zooniverse.
DOI: 10.5281/zenodo.5698539
title: Data for manuscript: "The Prevalence of Prejudice Denoting Terms in Spanish Newspapers"

description: This data set contains frequency counts of target words in 5 million news and opinion articles from 3 popular newspapers in Spain: El País, El Mundo and ABC. The target words are listed in the associated manuscript and are mostly words that denote some type of prejudice. A few additional words not denoting prejudice are also available since they are used in the manuscript for illustration purposes. The textual content of news and opinion articles from the outlets listed in Figure 1 of the main manuscript is available in the outlet's online domains and/or public cache repositories such as Google cache (https://webcache.googleusercontent.com), The Internet Wayback Machine (https://archive.org/web/web.php), and Common Crawl (https://commoncrawl.org). We used derived word frequency counts from original sources. Textual content included in our analysis is circumscribed to articles headlines and main body of text of the articles and does not include other article elements such as figure captions. Targeted textual content was located in HTML raw data using outlet specific xpath expressions. Tokens were lowercased prior to estimating frequency counts. To prevent outlets with sparse text content for a year from distorting aggregate frequency counts, we only include outlet frequency counts from years for which there is at least 1 million words of article content from an outlet. Yearly frequency usage of a target word in an outlet in any given year was estimated by dividing the total number of occurrences of the target word in all articles of a given year by the number of all words in all articles of that year. This method of estimating frequency accounts for variable volume of total article output over time. The list of compressed files in this data set is listed next: -analysisScripts.rar contains the analysis scripts used in the main manuscript -targetWordsInArticlesCounts.rar contains counts of target words in outlets articles as well as total counts of words in articles Usage Notes In a small percentage of articles, outlet specific XPath expressions can fail to properly capture the content of the article due to the heterogeneity of HTML elements and CSS styling combinations with which articles text content is arranged in outlets online domains. As a result, the total and target word counts metrics for a small subset of articles might not be precise. To conclude, in a data analysis of millions of news articles, we cannot manually check the correctness of frequency counts for every single article and hundred percent accuracy at capturing articles’ content is elusive due to the small number of difficult to detect boundary cases such as incorrect HTML markup syntax in online domains. Overall however, we are confident that our frequency metrics are representative of word prevalence in print news media content (see Figure 2 of main manuscript for supporting evidence).