cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21556726
title: Stability indicating Rp-UPLC method development and validation for the simultaneous estimation of fosnetupitant and palonosetron in bulk and injection dosage form

description: Abstract A stability indicating UPLC method has been developed and validated for the simultaneous determination of fosnetupitant and palonosetron in bulk and in injection dosage form. This combination is used for the prevention of acute and delayed nausea and vomiting associated with initial and repeated courses of highly emetogenic chemotherapy for cancer. The chromatographic analysis was performed on an HSS, RP C18 column (2.1 x 100 mm, 1.8 µm) with an isocratic mobile phase composed of 0.25 M potassium dihydrogen orthophosphate buffer (pH 6.5), pH adjusted with dilute sodium hydroxide:acetonitrile (55:45 v/v), at a flow rate of 0.5 mL/min, and the eluents were monitored at an isosbestic point of 286 nm. The developed method was validated according to the ICH guidelines pertaining to specificity, precision, accuracy, linearity and robustness, and the stability indicating nature of the method was established by forced degradation studies. The retention times of fosnetupitant and palonosetron were observed at 1.390 and 2.404 min, respectively. The developed method proved to be accurate and precise. Linearity was established between 4.70 and 14.10 µg/mL for fosnetupitant and between 0.05 and 0.15 µg/mL for palonosetron. The LOD and LOQ were 0.115 and 0.385 µg/mL, respectively, for fosnetupitant, and 0.005 and 0.016 µg/mL, respectively, for palonosetron. Therefore, the proposed UPLC method was reliable, reproducible, precise and sensitive for the quantification of fosnetupitant and palonosetron.
DOI: 10.6084/m9.figshare.21556713
title: Brassica rapa Chiifu v4.0 FL-LTR-RTs

description: Brassica rapa Chiifu v4.0 FL-LTR-RTs
DOI: 10.6084/m9.figshare.21556713.v1
title: Brassica rapa Chiifu v4.0 FL-LTR-RTs

description: Brassica rapa Chiifu v4.0 FL-LTR-RTs
DOI: 10.6084/m9.figshare.21556726.v1
title: Stability indicating Rp-UPLC method development and validation for the simultaneous estimation of fosnetupitant and palonosetron in bulk and injection dosage form

description: Abstract A stability indicating UPLC method has been developed and validated for the simultaneous determination of fosnetupitant and palonosetron in bulk and in injection dosage form. This combination is used for the prevention of acute and delayed nausea and vomiting associated with initial and repeated courses of highly emetogenic chemotherapy for cancer. The chromatographic analysis was performed on an HSS, RP C18 column (2.1 x 100 mm, 1.8 µm) with an isocratic mobile phase composed of 0.25 M potassium dihydrogen orthophosphate buffer (pH 6.5), pH adjusted with dilute sodium hydroxide:acetonitrile (55:45 v/v), at a flow rate of 0.5 mL/min, and the eluents were monitored at an isosbestic point of 286 nm. The developed method was validated according to the ICH guidelines pertaining to specificity, precision, accuracy, linearity and robustness, and the stability indicating nature of the method was established by forced degradation studies. The retention times of fosnetupitant and palonosetron were observed at 1.390 and 2.404 min, respectively. The developed method proved to be accurate and precise. Linearity was established between 4.70 and 14.10 µg/mL for fosnetupitant and between 0.05 and 0.15 µg/mL for palonosetron. The LOD and LOQ were 0.115 and 0.385 µg/mL, respectively, for fosnetupitant, and 0.005 and 0.016 µg/mL, respectively, for palonosetron. Therefore, the proposed UPLC method was reliable, reproducible, precise and sensitive for the quantification of fosnetupitant and palonosetron.
DOI: 10.6084/m9.figshare.21556731
title: Rapid tests for HIV, syphilis, and chronic hepatitis in a prison population in a prison complex in Salvador (BA), Brazil

description: Abstract This study aimed to quantitatively analyze the results of rapid tests for Human Immunodeficiency Virus (HIV), Syphilis, and Chronic Hepatitis in the prison population in a prison complex in Salvador (BA), Brazil. This cross-sectional study consisted of a sample of men incarcerated from August 2018 to August 2020 submitted to rapid tests. Descriptive statistics and prevalence ratios with respective 95% confidence intervals were employed to analyze data. A total of 6,160 men were studied. Most were black and brown (93.1%) and resided in Salvador (BA), Brazil (65.8%), with predominantly elementary schooling level (65.3%). Five hundred eighty-one (9.4%) people deprived of their liberty were positive for one or more STIs, and Syphilis was the most prevalent (80%). The variables age greater than 25 years [PR = 1.37 95%CI (1.17-1.61)] and schooling level without Higher Education [PR = 2.16 95%CI (1.04-4.49)] were associated with a higher positivity rate in tests, while not sharing drugs was a protective factor for test positivity [PR = 1.28 95%CI (1.07-1.53)]. We concluded that there was a low prevalence of STIs in the sample studied, and Syphilis was the most prevalent.
DOI: 10.6084/m9.figshare.21556731.v1
title: Rapid tests for HIV, syphilis, and chronic hepatitis in a prison population in a prison complex in Salvador (BA), Brazil

description: Abstract This study aimed to quantitatively analyze the results of rapid tests for Human Immunodeficiency Virus (HIV), Syphilis, and Chronic Hepatitis in the prison population in a prison complex in Salvador (BA), Brazil. This cross-sectional study consisted of a sample of men incarcerated from August 2018 to August 2020 submitted to rapid tests. Descriptive statistics and prevalence ratios with respective 95% confidence intervals were employed to analyze data. A total of 6,160 men were studied. Most were black and brown (93.1%) and resided in Salvador (BA), Brazil (65.8%), with predominantly elementary schooling level (65.3%). Five hundred eighty-one (9.4%) people deprived of their liberty were positive for one or more STIs, and Syphilis was the most prevalent (80%). The variables age greater than 25 years [PR = 1.37 95%CI (1.17-1.61)] and schooling level without Higher Education [PR = 2.16 95%CI (1.04-4.49)] were associated with a higher positivity rate in tests, while not sharing drugs was a protective factor for test positivity [PR = 1.28 95%CI (1.07-1.53)]. We concluded that there was a low prevalence of STIs in the sample studied, and Syphilis was the most prevalent.
DOI: 10.6084/m9.figshare.21556732
title: INFLUENCE OF HIGH-INTENSITY EXERCISE ON PHYSICAL FITNESS OF SWIMMERS

description: ABSTRACT Introduction High-intensity swimming requires athletes to have explosive power, endurance, lactic acid resistance, aerobic metabolism, and other qualities. Pre-competition physical training is mainly based on high interval training, promoting ATP-CP synthesis in the body. It can enhance the resistance to lactic acid and promote lactic acid clearance. Objective This article explores the effect of high-intensity pre-competition training on the physical fitness of swimmers. The results can be used as a reference for swimmers to perform high-intensity training before the competition. Methods Eight swimmers were selected by random sampling. The study subjects received eight weeks of high-intensity training before the competition. The athletes’ gas metabolism and anaerobic thresholds were detected before and after training. At the same time, the physiological and chemical indicators of the experimental subjects were detected in this paper. Finally, this paper analyzes the experimental results by employing mathematical statistics. Results The metabolism function of the athletes changed significantly in the later period of pre-competition training (P&lt;0.05). Serum lactate concentration had no significant effect on the anaerobic threshold (P&gt;0.05). Conclusion High-intensity exercise has a particular promotion effect on improving the physical quality of swimmers. This exercise can lay a solid foundation for the swimmer’s physical fitness. Level of evidence II; Therapeutic studies – investigation of treatment results.
DOI: 10.6084/m9.figshare.21556732.v1
title: INFLUENCE OF HIGH-INTENSITY EXERCISE ON PHYSICAL FITNESS OF SWIMMERS

description: ABSTRACT Introduction High-intensity swimming requires athletes to have explosive power, endurance, lactic acid resistance, aerobic metabolism, and other qualities. Pre-competition physical training is mainly based on high interval training, promoting ATP-CP synthesis in the body. It can enhance the resistance to lactic acid and promote lactic acid clearance. Objective This article explores the effect of high-intensity pre-competition training on the physical fitness of swimmers. The results can be used as a reference for swimmers to perform high-intensity training before the competition. Methods Eight swimmers were selected by random sampling. The study subjects received eight weeks of high-intensity training before the competition. The athletes’ gas metabolism and anaerobic thresholds were detected before and after training. At the same time, the physiological and chemical indicators of the experimental subjects were detected in this paper. Finally, this paper analyzes the experimental results by employing mathematical statistics. Results The metabolism function of the athletes changed significantly in the later period of pre-competition training (P&lt;0.05). Serum lactate concentration had no significant effect on the anaerobic threshold (P&gt;0.05). Conclusion High-intensity exercise has a particular promotion effect on improving the physical quality of swimmers. This exercise can lay a solid foundation for the swimmer’s physical fitness. Level of evidence II; Therapeutic studies – investigation of treatment results.
DOI: 10.6084/m9.figshare.21556737
title: Formaldehyde analysis of seized cosmetic products by HS-GC-MS of methylal, ethoxymethoxymethane, and ethylal derivatives

description: Abstract Formaldehyde is a carcinogenic compound used as preservative in cosmetic products. In this study, a derivatization procedure using MeOH, EtOH and HCl (25:25:1), and incubation at 60ºC for 4 hours was optimized, and the derivatized products - methylal, ethoxymethoxymethane (EMM), and ethylal - were directly analyzed by headspace-gas chromatography-mass spectrometry (HS-GC-MS) to determine formaldehyde concentrations. The validated method provided good linearity of the standard curve, selectivity, recovery (89.6-106.6%), repeatability, and intermediate precision (RSD &lt; 12%), with an LOD of 0.0015% and an LOQ of 0.005% for all derivatized analytes. The validated method showed to be fast, clean, and easy to implement in a laboratory. To the best of our knowledge, this is the first reported HS-GC-MS procedure to determine formaldehyde as methylal, ethylal, and EMM as derivatized compounds. The method was satisfactorily applied for the analysis of nine hair-straightener cream samples seized by the Civil Police of the Federal District, Brazil. Eight samples contained formaldehyde, at levels ranging from 0.33 to 4.02 %, higher than the legal levels, indicating the need to control the levels of this toxic compound in cosmetic products.
DOI: 10.6084/m9.figshare.21556737.v1
title: Formaldehyde analysis of seized cosmetic products by HS-GC-MS of methylal, ethoxymethoxymethane, and ethylal derivatives

description: Abstract Formaldehyde is a carcinogenic compound used as preservative in cosmetic products. In this study, a derivatization procedure using MeOH, EtOH and HCl (25:25:1), and incubation at 60ºC for 4 hours was optimized, and the derivatized products - methylal, ethoxymethoxymethane (EMM), and ethylal - were directly analyzed by headspace-gas chromatography-mass spectrometry (HS-GC-MS) to determine formaldehyde concentrations. The validated method provided good linearity of the standard curve, selectivity, recovery (89.6-106.6%), repeatability, and intermediate precision (RSD &lt; 12%), with an LOD of 0.0015% and an LOQ of 0.005% for all derivatized analytes. The validated method showed to be fast, clean, and easy to implement in a laboratory. To the best of our knowledge, this is the first reported HS-GC-MS procedure to determine formaldehyde as methylal, ethylal, and EMM as derivatized compounds. The method was satisfactorily applied for the analysis of nine hair-straightener cream samples seized by the Civil Police of the Federal District, Brazil. Eight samples contained formaldehyde, at levels ranging from 0.33 to 4.02 %, higher than the legal levels, indicating the need to control the levels of this toxic compound in cosmetic products.
DOI: 10.6084/m9.figshare.21556738
title: EFFECTS OF STRETCHING TRAINING ON LOWER LIMB EXPLOSIVE STRENGTH IN FIGURE SKATING ATHLETES

description: ABSTRACT Introduction Figure skating is characterized by a high degree of flexibility, balance, and technical precision. It belongs to the sports group that combines high speed and endurance. Therefore, it is very important for athletes to correctly master these techniques and physical strength and execute precise movements in their performances. Objective Explore the effect of stretching training on the lower limb explosive strength of figure skating athletes. Methods 20 outstanding male figure skaters from the Chinese team were selected as volunteers. The experimental method was used using the OPTOJUMP test system, among other instruments, for comparison of pre and post-intervention results. Results Through scientific observation, it was found that skaters have less requirement for upper limb strength training, minimizing its importance because upper limb strength training can assist in motor coordination of athletes’ lower limbs and help them stabilize to perform dynamic movements. Therefore upper limb strength training is also emphasized in the proposed training. Conclusion The stretching training on the lower limb strength of figure skating athletes proved to be useful for the improvement of performance and execution of the intrinsic movements of the sport. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.21556738.v1
title: EFFECTS OF STRETCHING TRAINING ON LOWER LIMB EXPLOSIVE STRENGTH IN FIGURE SKATING ATHLETES

description: ABSTRACT Introduction Figure skating is characterized by a high degree of flexibility, balance, and technical precision. It belongs to the sports group that combines high speed and endurance. Therefore, it is very important for athletes to correctly master these techniques and physical strength and execute precise movements in their performances. Objective Explore the effect of stretching training on the lower limb explosive strength of figure skating athletes. Methods 20 outstanding male figure skaters from the Chinese team were selected as volunteers. The experimental method was used using the OPTOJUMP test system, among other instruments, for comparison of pre and post-intervention results. Results Through scientific observation, it was found that skaters have less requirement for upper limb strength training, minimizing its importance because upper limb strength training can assist in motor coordination of athletes’ lower limbs and help them stabilize to perform dynamic movements. Therefore upper limb strength training is also emphasized in the proposed training. Conclusion The stretching training on the lower limb strength of figure skating athletes proved to be useful for the improvement of performance and execution of the intrinsic movements of the sport. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.21556740
title: MULTIVARIATE ANALYSIS OF SOURSOP UNDER SALT STRESS AND EXOGENOUS APPLICATION OF HYDROGEN PEROXIDE1

description: ABSTRACT The objective of this study was to evaluate, through multivariate data analysis, the effect of exogenous application of hydrogen peroxide on the photosynthetic pigments, gas exchange and growth of soursop seedlings under salt stress. The study was conducted in a greenhouse, at Federal University of Campina Grande - Paraíba. The assay was carried out from May to October 2018. The treatments were distributed in a randomized block design, in a 5 × 5 factorial arrangement, corresponding to five levels of irrigation water electrical conductivity - ECw (0.6-control, 1.2, 1.8, 2.4, and 3.0 dS m-1) and five concentrations of hydrogen peroxide - H2O2 (0, 10, 20, 30, and 40 μM), with two plants per plot and four replicates. Irrigation water salinity from 1.2 dS m-1 negatively affected the biosynthesis of photosynthetic pigments, gas exchange and growth of soursop. Application of hydrogen peroxide at the concentration of 20 μM resulted in attenuation of salt stress effects on the biosynthesis of photosynthetic pigments, gas exchange and growth of soursop. Hydrogen peroxide concentrations above 30 μM intensified the deleterious effect of irrigation water salinity on the photosynthetic pigments, gas exchange and growth of soursop.
DOI: 10.6084/m9.figshare.21556740.v1
title: MULTIVARIATE ANALYSIS OF SOURSOP UNDER SALT STRESS AND EXOGENOUS APPLICATION OF HYDROGEN PEROXIDE1

description: ABSTRACT The objective of this study was to evaluate, through multivariate data analysis, the effect of exogenous application of hydrogen peroxide on the photosynthetic pigments, gas exchange and growth of soursop seedlings under salt stress. The study was conducted in a greenhouse, at Federal University of Campina Grande - Paraíba. The assay was carried out from May to October 2018. The treatments were distributed in a randomized block design, in a 5 × 5 factorial arrangement, corresponding to five levels of irrigation water electrical conductivity - ECw (0.6-control, 1.2, 1.8, 2.4, and 3.0 dS m-1) and five concentrations of hydrogen peroxide - H2O2 (0, 10, 20, 30, and 40 μM), with two plants per plot and four replicates. Irrigation water salinity from 1.2 dS m-1 negatively affected the biosynthesis of photosynthetic pigments, gas exchange and growth of soursop. Application of hydrogen peroxide at the concentration of 20 μM resulted in attenuation of salt stress effects on the biosynthesis of photosynthetic pigments, gas exchange and growth of soursop. Hydrogen peroxide concentrations above 30 μM intensified the deleterious effect of irrigation water salinity on the photosynthetic pigments, gas exchange and growth of soursop.
DOI: 10.6084/m9.figshare.21556743
title: INFLATION EXPECTATIONS: A SYSTEMATIC LITERATURE REVIEW AND BIBLIOMETRIC ANALYSIS

description: ABSTRACT The main purpose of this work is to conduct a systematic literature review regarding inflation expectations, their determinants, and their implications for policy making in Latin America. The analysis shows the importance of inflation expectations in the countries that use an inflation targeting scheme, while also supporting the idea that inflation expectations can affect other sectors of the economy. As for the determinants of expectations, the findings show the importance of past iterations of expectations, supporting the idea that the inflation expectations are heavily determined by themselves. The amount of research being conducted in this field is not comprehensive. This is even more evident in the Latin American region since it is a recent research field with a meager number of publications, deeming our study useful for future research. The classification process makes it easier to know the most common variables and econometric methods used to find the determinants of inflation expectations and their impact on other economic variables.
DOI: 10.6084/m9.figshare.21556743.v1
title: INFLATION EXPECTATIONS: A SYSTEMATIC LITERATURE REVIEW AND BIBLIOMETRIC ANALYSIS

description: ABSTRACT The main purpose of this work is to conduct a systematic literature review regarding inflation expectations, their determinants, and their implications for policy making in Latin America. The analysis shows the importance of inflation expectations in the countries that use an inflation targeting scheme, while also supporting the idea that inflation expectations can affect other sectors of the economy. As for the determinants of expectations, the findings show the importance of past iterations of expectations, supporting the idea that the inflation expectations are heavily determined by themselves. The amount of research being conducted in this field is not comprehensive. This is even more evident in the Latin American region since it is a recent research field with a meager number of publications, deeming our study useful for future research. The classification process makes it easier to know the most common variables and econometric methods used to find the determinants of inflation expectations and their impact on other economic variables.
DOI: 10.6084/m9.figshare.21556747
title: Double burden of malnutrition as a risk factor for overweight and obesity

description: ABSTRACT OBJECTIVE To assess the longitudinal effect of double burden of malnutrition (DBM) on the risk of developing child and adolescent overweight or obesity. METHODS Analysis of the Peruvian Young Lives Study, younger cohort: baseline (2002) and 4 follow-ups (2006–2007, 2009–2010, 2013–2014, and 2016–2017). Outcomes were the incidence of overweight and obesity as defined by the World Health Organization standards. The exposure comprised a variable with 4 categories: non-stunted child with a non-overweight mother (reference group), non-stunted child with an overweight mother, stunted child with a non-overweight mother, and stunted child with an overweight mother (i.e., DBM). Poisson regression models were built to assess the association of interest, and relative risks (RR) and 95%CI were reported. RESULTS Data from 2,034 children; 50.0% were girls and the mean age was 12.0 (3.6) months at baseline. Non-stunted children with an overweight mother had greater risk (RR = 1.64; 95%CI: 1.35–1.99) of developing overweight, compared with the risk for stunted children with a non-overweight mother (RR = 1.38; 95%CI: 1.10–1.72), and for those with DBM (RR = 1.28; 95%CI: 1.02–1.61). When compared with the reference group, obesity risk was greater among non-stunted children with an overweight mother (RR = 2.33; 95%CI: 1.68–3.22), greater among stunted children with a non-overweight mother (RR = 2.59; 95%CI: 1.75–3.84), and greater among those with DBM (RR = 2.14; 95%CI: 1.39–3.28). CONCLUSIONS DBM is a risk factor for childhood overweight and obesity in Peru. Dual-duty policies tackling both undernutrition in children and overweight in mothers are needed to reduce DBM and its future effects in Peru.