cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22691386.v2
title: Untitled Item

description: The MIDOG++ dataset represents an extension of the data set used in the MIDOG 2021 and 2022 challenges. We provide region of interest images from 503 histological specimens of seven different tumor types with variable morphology: breast carcinoma, lung carcinoma, lymphosarcoma, neuroendocrine tumor, cutaneous mast cell tumor, cutaneous melanoma, and (sub)cutaneous soft tissue sarcoma. The human and canine samples were processed and stained at different human and veterinary pathology laboratories with standard H&E dye and digitized with different digital whole slide image scanners. We provide labels for 11,937 mitotic figures that have been differentiated against 14,351 imposter cells in a blinded consensus by two pathologists and a final decision by a third pathologist for disagreed labels.
DOI: 10.6084/m9.figshare.27999704.v1
title: Betz-Koch et al. 2025

description: Raw data
DOI: 10.6084/m9.figshare.29153168.v1
title: Finnsheep reference genome (Oar_Finn): TAD report

description: Summary statistics from TAD analysis that was based on Hi-C data from a Finnsheep ewe.
DOI: 10.6084/m9.figshare.5127352.v1
title: Supplementary Material for: Overcoming Treatment Resistance in Chronic Depression: A Pilot Study on Outcome and Feasibility of the Cognitive Behavioral Analysis System of Psychotherapy as an Inpatient Treatment Program

description: <b><i>Background:</i></b> The Cognitive Behavioral Analysis System of Psychotherapy (CBASP), initially developed as an outpatient treatment for chronic depression (CD), has been adapted as a multidisciplinary 12-week inpatient program for CD. <b><i>Methods:</i></b> Seventy inpatients with CD and treatment resistance were included in a noncontrolled trial. The Hamilton Depression Rating Scale served as the primary outcome measure. Prospective naturalistic follow-up assessments were conducted 6 and 12 months after discharge. <b><i>Results:</i></b> Dropout rate was 7.1%; 90.4% perceived the program as helpful. Pre-post comparisons yielded strong effect sizes; 75.7% of the intention-to-treat sample responded, and 40.0% remitted. Nonremission was associated with experiencing temporary deterioration of symptoms during treatment. After 6 months 75.0% and after 12 months 48.0% of patients sustained response. <b><i>Conclusions:</i></b> The CBASP program appears as a feasible acute treatment for treatment-resistant CD inpatients with promising outcome. However, the continuation of treatment after discharge should be optimized especially for patients with subjective deterioration during treatment.
DOI: 10.6084/m9.figshare.6508205.v4
title: Comprehensive analysis of Long non-coding RNA expression in dorsal root ganglion reveals cell type specificity and dysregulation following nerve injury - Supplemetary Data

description: <b>Comprehensive analysis of Long non-coding RNA expression in dorsal root ganglion reveals cell type specificity and dysregulation following nerve injury - Supplemetary Data</b> <br>S. Data 1: Novel LncRNAs in mouse and rat, in syntenically conserved regions between human, mouse and rat.<br> <br>S. Data 2: Novel LncRNAs in mouse DRG antisense of orthologous genes in mouse and rat. <br>S. Data 3: Novel LncRNAs in rat DRG antisense of orthologous genes in mouse and rat. <br>S. Data 4: Neuron sub-type specificity of ENSEMBL genes and novel LncRNAs. Neuron sub-type index is 1. MHN, 2. MHN (MI, IS), 3. C-LTMR, 4. MHN (IS), 5. MHN (IS), 6. MHN, 7. MHN (NS), 8. MR, 9. MHN, 10. MR. Average log2 expression holds the average expression in the neuron sub-type where the gene or LncRNAs was higher expressed. Expression SEM hold the standard error of the mean for the average expression estimator. <br>S. Data 5: DE analysis results and fpkm values of novel LncRNAs for IPSC-derived sensory neurons vs IPSC. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ cell_line*condition. <br>S. Data 6: Expression data for all antisense LncRNAs in IPSC-derived sensory neurons vs IPSC. <br>S. Data 7: Expression data for all intergenic LncRNAs in IPSC-derived sensory neurons vs IPSC. <br>S. Data 8: Expression data for all LncRNAs antisense of pain genes in IPSC-derived sensory neurons vs IPSC. <br>S. Data 9: Expression data for all intergenic LncRNAs adjacent to pain genes in IPSC-derived sensory neurons vs IPSC. <br>S. Data 10: Novel LncRNAs in human IPSC and mouse, in syntenically conserved regions between human, mouse and rat. <br>S. Data 11: Novel LncRNAs in human IPSC antisense of orthologous genes in human and mouse. <br>S. Data 12: DE analysis results and fpkm values of novel LncRNAs for rat DRG SNT vs Sham. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ condition. <br>S. Data 13: Expression data for all antisense LncRNAs in rat DRG SNT vs Sham. <br>S. Data 14: Expression data for all intergenic LncRNAs rat DRG SNT vs Sham. <br>S. Data 15: DE analysis results and fpkm values of novel LncRNAs for BALB/c and B10.D2 mouse DRG SNI vs Sham. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ sex + strain*condition. <br>S. Data 16: Expression data for all antisense LncRNAs in mouse DRG SNI vs Sham.<br> <br>S. Data 17: Expression data for all intergenic LncRNAs mouse DRG SNI vs Sham.
DOI: 10.6084/m9.figshare.7264667.v1
title: Gene duplication and evolution in recurring polyploidization-diploidization cycles in plants

description: Supporting data for "Gene duplication and evolution in recurring polyploidization-diploidization cycles in plants".
DOI: 10.17632/66mcwyk854
title: Data for: Does Dynamic Tape change the walking biomechanics of women with greater trochanteric pain syndrome? A double-blind randomised controlled crossover trial.
DOI: 10.17632/bd8jn26hzz
title: Data for: Optimization of Electric Vehicle Scheduling with Multiple Vehicle Types in Public Transport
DOI: 10.17632/wtxgwgc3yx
title: Mobile wallets 

description: Research project titled -What drives customer preference for mobile wallet payments - Evidence from India
DOI: 10.17632/xftgvhs97m
title: Green Marketing and Its Impact on Consumer Behavior in MSMEs Exploring Sustainable Environment Business Strategies

description: In conclusion, the study highlights the significant impact of green marketing on consumer behavior, particularly in the context of Micro, Small, and Medium Enterprises (MSMEs) that adopt sustainable environmental strategies. Key findings from the research suggest that green marketing plays an essential role in enhancing purchase intention and customer loyalty, which in turn positively influence customer responses to environmentally friendly products
DOI: 10.6084/m9.figshare.25039910.v1
title: Can the morphological traits of benthic testate amoebae in a freshwater lake be indicators of depth and environmental conditions.xlsx

description: Testate amoebae are widely used as proxies in palaeoecological reconstructions of lacustrine environments. However, our knowledge on their morphological adaptation to depth is still limited. This study aims to determine the correlations between the morphological and size structure of testate amoeba communities and depth and some other environmental variables along a depth gradient from 0 to 57 m in mesotrophic Valdayskoe Lake, Russia. The morphological structure of testate amoeba communities in the bottom surface sediments of the lake and their distribution along the depth gradient were described. The results of the Redundancy analysis indicated that sampling depth, temperature, pH, and slope angle significantly explained the total variance in the morphotypes community compositions, which were classified into three morphological groups. The set of morphotraits of testate amoebae communities differed drastically above and below the thermocline and may be used as an indicator of the depths. Above and below the thermocline, the morphological structure of testaceans is also determined by other environmental variables associated with the habitats they were found. The weighted and median body size of testate amoebae generally decreases with depth, but bottom relief influences the body size structure of the community via differences in the accumulation of organic matter on slopes and flat sites. These data may contribute to a better interpretation of palaeoecological records of subfossil testate amoebae in lacustrine surface sediments and serve as a basis for the development of a transfer function for reconstructing lake depths.
DOI: 10.6084/m9.figshare.25751289.v1
title: Single-molecule force spectroscopy data for prion-like conversion of wild-type SOD1 by pathogenic mutants G127X and G85R

description: Excel files containing (A) force-extension curve data and (B) ensemble assay data for studies on prion-like propagation of misfolding in SOD1.(A) Force-extension curve data from optical tweezers measurements of the unfolding and refolding of: (i) wild-type (WT)-G127X heterodimers of superoxide dismutase-1 (SOD1), pulling on the termini of the WT domain; (ii) WT-G127X SOD1 heterodimers pulling on the termini of the G127X domain; (iii) WT-G85R SOD1 heterodimers, pulling on the termini of the WT domain; and (iv) WT-WT homodimers (control), pulling on the termini of one of the WT domains. The file title indicates which construct was used in the measurements. In each file, data are presented as paired columns of force ("F", values listed in pN) and extension ("Ext", values listed in nm) data for sequential unfolding and refolding measurements (refolding data indicated by "_r" in column titles). The remainder of the column name indicates the molecule number (molecule 1, 2,...), followed by an underscore and the number for the set of curves measured from that molecule (set 1, 2,...), followed by an underscore and the number of the pull within that set (pull 1, 2,...). Each set of FECs is organized in a separate sheet in each file, with the tabs for the sheets labelled in the format MoleculeNumber_SetNumber.(B) Data from enzymatic assays and mass photometry assays of prion-like conversion in SOD1. Conversion assay results show the percent inhibition of WST-1 formazan formation by SOD1 at different time-points and under different solution conditions. Mass photometry results list the masses for all binding and unbinding events (respectively, positive and negative values) with SOD1 heterodimer alone, 10C12 antibody alone, and SOD1+antibody, at 0 and 48 hr incubation times.
DOI: 10.6084/m9.figshare.26830423.v1
title: <b>Оценка эффективности применения ранней селективной плазмофильтрации в составе комплексной интенсивной терапии у пациентов с абдоминальным септическим шоком: проспективное мультицентровое исследование</b>

description: <b><i>Актуальность.</i></b>Выбор тактики применения экстракорпоральной детоксикации (ЭКД), показаний, модальности процедур у больных с абдоминальным септическим шоком (СШ) остается не решенной проблемой.<b><i>Цель исследования.</i></b>Оценить влияние ранней селективной плазмофильтрации (СПФ) на динамику маркеров синдрома системной эндогенной интоксикации, тяжесть состояния и исходов заболевания <b>у </b>больных с абдоминальным СШ.<b><i>Материалы и методы.</i></b>В исследование включены 85 пациентов с клиникой абдоминального СШ осложненного острым повреждением почек (KDIGO I) получавшие стандартную интенсивную терапию. 1 группа: 23 пациента, применяли СПФ сочетанную с непрерывной вено-венозной гемофильтрацией (ПВВГДФ). 2 группа (контроль): 62 пациента, получали изолированную ПВВГДФ. Выполняли сравнительный анализ основных клинико-лабораторных показателей и исходов лечения между группами.<b><i>Результаты.</i></b>Применение ранней комбинированной ЭКД позволило снизить маркеры системной эндогенной интоксикации: СРБ с 225,4 (211; 248,4) до 210,5 (180,39; 230,18) мг/л к 3-м суткам терапии (6,6%; <i>р</i>=0,0016), к 5-7-10-м суткам 156,17 (110,67; 180,62), 87 (74,5; 94,1), 62,2 (45,7; 71) соответственно (30,7-61,4-72,4%; <i>р</i>=0,044; <i>р</i>=0,0001; <i>р</i>=0,0001); ИЛ-6 продемонстрировал снижение на 12,2% ко 2-м суткам (<i>р</i>=0,017) и 35,5, 39,4, 45,7 и 52,4% к 3-5-7-10 суткам терапии соответственно (<i>р</i>=0,022; <i>р</i>=0,009; <i>р</i>=0,0018; <i>р</i>=0,0001); лейкоциты с 19,7 (17,7;22,4) до 17,25 х10<sup>9</sup>/л (14,65; 19,15) к 3-м суткам (12,4%; <i>р</i>=0,00045), и 10,9 (9,3;14,1) 10-м суткам (44,7%; <i>р</i>=0,00048). Тяжесть органной дисфункции (SOFA) с 6 (4; 6) в 1-е сутки до 4 (3; 5) баллов к 3-м суткам терапии (<i>р</i>=0,026). Получена достоверная разница по выживаемости (<i>р</i>=0,037).<b><i>Выводы.</i></b><b> </b>Ранняя комбинированная ЭКД (СПФ и ПВВГДФ)<b> </b>позволяет быстро нормализовать лабораторные маркеры синдрома системной эндогенной интоксикации и улучшить выживаемость пациентов.<b><i>Ключевые слова:</i></b><b> </b>абдоминальный септический шок, синдром системный эндогенной интоксикации, селективная плазмофильтрация, интерлейкин-6, продленная вено-венозная гемодиафильтрация, острое повреждение почек.
DOI: 10.6084/m9.figshare.6400394.v2
title: fern transcriptome assemblies

description: assemblies of fern transcriptomes.
DOI: 10.6084/m9.figshare.5120491.v1
title: Supplementary Material for: Valproic Acid and All-Trans Retinoic Acid: Meta-Analysis of a Palliative Treatment Regimen in AML and MDS Patients

description: Currently, no standard treatment is available for elderly patients with de novo/secondary acute myeloid leukemia (AML) who are not eligible for intensive chemotherapy. New, less aggressive therapies are therefore needed. Histone deacetylase inhibitors (HDACi) are known to reduce proliferation and induce differentiation in hematological malignancies. With all-trans retinoic acid (ATRA) these effects have been reported to be even enhanced. Valproic acid (VPA) is an HDACi and has been known as anti-epileptic agent for many years. We treated 21 patients with de novo/secondary AML and 1 patient with myelodysplastic syndrome with ATRA (45 mg/m<sup>2</sup>/day in 2 doses, 14 days, q29 days) and VPA (150 mg/day 1 week, then 300 mg/day, continuously). Treatment was tolerated well with moderate side effects. 4 patients revealed hematological improvement and another 4 patients experienced a reduction in transfusion dependency. The overall response rate was 27%. Our study is presented together with an overview of the literature on the topic.
DOI: 10.17632/ngvnm5tty7
title: SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging

description: Sirtuins enzymes are heavily implicated in senescence and aging. The regulation of sirtuin proteins is tightly controlled but how sirtuin levels are regulated during aging and how they elicit tissue-specific cellular changes are unclear. We demonstrate that SIRT7 is targeted for degradation during senescence and is regulated by E3 Ligase TRIP12. We identified transcription factor NUCKS1 interacts with SIRT7 and is recruited onto chromatin during senescence. This is mediated by SIRT7 loss and subsequent increase of NUCKS1 acetylation. NUCKS1 depletion delayed senescence leading to reduced inflammatory gene expression associated with RELA, and CEBP. In Sirt7 KO mouse and aged livers, NUCKS1 was bound at promoters and enhancers of age-related genes and these regions gain accessibility during aging. Overall, our results uncover NUCKS1 as a interactor of SIRT7 and proteosomal loss of SIRT7 during senescence and liver aging promotes NUCKS1 acetylation and chromatin binding to induce metabolic and inflammatory genes.
DOI: 10.6084/m9.figshare.1472936.v1
title: ACUTE EFFECTS OF JAW CLENCHING USING A CUSTOMIZED MOUTHGUARD ON ANAEROBIC ABILITY AND VENTILATORY FLOWS

description: This article is an original research on the acute effects of custom-made mouthguard on athletic performance. The latest findings on the ergogenic effects of a dentistry-design, bite-aligning mouthpiece require additional research to assess its impact on anaerobic ability and ventilatory parameters. This paper was aimed at determining the ergogenic acute effects of wearing a custom-made mouthpiece on oral airflow dynamics, 30-sec Wingate Anaerobic Test performance parameters. Twenty-eight healthy and physically-active male subjects (age: 24.50 ± 3.32, height: 181.34 ± 7.4, weight: 78.14 ± 8.21), were voluntarily studied. The subjects were first briefed on the test protocols, and then performed the 30s Wingate test and Spirometer test. The experimental trials were performed in a random counterbalanced order. We evaluate maximum expiratory volume (VEmax L·min-1), mean power (W·Kg-1), peak power (W·Kg-1), time to peak (s), rate to fatigue (W·s -1) and lactate production (mMol·L-1), rate of perceived exertion (RPE). There were significant differences between mouthguard and no-mouthguard conditions in mean power (W·Kg-1), peak power (W·Kg-1), time to peak (s), and rate to fatigue (W·s-1) for the 30-sec Wingate Anaerobic Test. Significantly lower lactate production (mMol·L-1) was observed, in mouthguard condition but no significant differences were found in RPE. In airflow dynamics, the VEmax L·min-1 was significantly higher when comparing the mouthguard and the no mouthguard conditions in both forced and unforced conditions.
DOI: 10.6084/m9.figshare.14937621.v1
title: Supplementary Material for: Involvement of the Auditory Pathway in Spinocerebellar Ataxia Type 7

description: <b><i>Background:</i></b> Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a mutation in the <i>ATXN7</i> gene. The involvement of the brainstem auditory pathway in pathogenesis of this disease has not been systematically assessed. <b><i>Aim:</i></b> To determine involvement of the brainstem auditory pathway in SCA7 patients and its relationship to clinical features of the disease. <b><i>Methods:</i></b> In this case-control study, brainstem auditory-evoked potentials (BAEPs) were assessed in 12 SCA7 patients with clinical and molecular diagnosis, compared to 2 control groups of 16 SCA2 patients and 16 healthy controls. <b><i>Results:</i></b> SCA7 patients exhibited significant prolongation of I-wave and III-wave latencies, whereas SCA2 patients showed increased latencies for III and V waves and I–III interpeak interval. SCA7 patients with larger I-wave latencies exhibited larger CAG repeats, earlier onset age, and higher SARA scores, but in SCA2 cases, these were not observed. <b><i>Conclusions:</i></b> BAEP tests revealed functional involvement of the auditory pathway in SCA7 (mainly at) peripheral portions, which gave new insights into the disease physiopathology different from SCA2 and may unravel distinct pathoanatomical effects of polyQ expansions in the central nervous system. <b><i>Significance:</i></b> These findings offer important insights into the distinctive disease mechanisms in SCA7 and SCA2, which could be useful for differential diagnosis and designing specific precision medicine approaches for both conditions.
DOI: 10.6084/m9.figshare.19403054.v1
title: Grit, Posttraumatic Growth and Life Satisfaction

description: Longitudinal study on grit, posttraumatic growth after COVID-19 and life satisfaction at the beginning and end of the school year
DOI: 10.6084/m9.figshare.28254434.v1
title: Skin microbiota profiles and volatility following an exposure to <i>Batrachochytrium salamandrivorans </i>do not correlate with the intensity and severity of chytridiomycosis disease in <i>Pleurodeles waltl</i>.

description: Data and script used in Fieschi-Méric et al., (in revision) 'Skin microbiota profiles and volatility following an exposure to <i>Batrachochytrium salamandrivorans </i>do not correlate with the intensity and severity of chytridiomycosis disease in <i>Pleurodeles waltl</i>.'.DOI: to come once published
DOI: 10.6084/m9.figshare.5678737.v1
title: Dataset1 and putative SNPs under selection

description: Dataset 1 contains the called genotypes for 60 plains zebras, 3 Grevy's zebras, 3 mountain zebras and one Quagga zebra. A total of 98,512 SNPs were called. The data is based on the RADseq technology. We used a missingness filter of 0.2 and excluded monomorphic sites.<br>We also include a list of SNPs inferred from pcadapt, which are putatively under selection.<br><br>
DOI: 10.6084/m9.figshare.5759520.v1
title: Survey.sav

description: Full data set Ego Depletion Survey<br>
DOI: 10.17632/96xjz92ttj
title: Moringa leaves

description: The dataset I have compiled consists of over 500 images of Moringa leaves, meticulously categorized into "good" and "bad" classes. These images were captured using a Samsung mobile cam J7 Next Era, ensuring consistent image quality and resolution throughout the dataset. To maintain uniformity and minimize distractions, each leaf was photographed against a white background. The data collection process was conducted under daylight conditions, leveraging natural illumination to ensure accurate representation of the leaves' visual characteristics.

The key features of this dataset are as follows:

Image Variability: The dataset captures a wide range of Moringa leaves, showcasing variations in size, shape, texture, and overall condition. This diversity is essential for training robust classification models capable of accurately distinguishing between healthy and unhealthy leaves.

Annotation: Each image in the dataset is meticulously annotated to indicate whether the Moringa leaf falls under the "good" or "bad" category. These annotations serve as ground truth labels for supervised learning algorithms, facilitating the development of accurate classification models.

Consistent Background: To maintain consistency and minimize noise, all images feature a uniform white background. This deliberate choice eliminates distractions and ensures that the focus remains solely on the visual attributes of the Moringa leaves.

Daylight Conditions: The data collection process was carried out under natural daylight conditions to ensure consistent illumination across all images. Natural light enhances the visibility of leaf features and minimizes lighting variations, contributing to the authenticity and quality of the dataset.

High-Quality Images: Images captured with the Samsung mobile cam J7 Next Era exhibit high resolution and clarity, enabling detailed analysis of leaf characteristics. The quality of the images facilitates precise feature extraction, a crucial aspect of building accurate classification models.

Large Dataset Size: With over 500 images, the dataset provides a substantial volume of data for model training and validation. A larger dataset enhances model generalization and reduces the risk of overfitting, leading to improved classification performance on unseen data.
DOI: 10.17632/k53sbjzjdp
title: Original images for Pal et al., NAR 2022

description: Raw uncropped western blotting and microscopy images that were used for generating figures as discussed in Pal et al., NAR 2022