DOI: 10.5281/zenodo.17238287
title: Effort_Less Processed fMRI

description: Dataset Description

This dataset consists of preprocessed functional MRI (fMRI) data collected as part of the research study titled "Trait-like neural signatures of physical effort perception dissociated from motor execution in humans." The study investigates how individual differences in the perception of physical effort are represented in the brain, independently of motor output.

Diego Lombardo led the preprocessing and analysis of the fMRI data and was primarily responsible for the conceptual design of the analytical framework. He also played a central role in preparing and writing the manuscript associated with this dataset. The initial analyses were guided by the very rich set of hypotheses outlined in the ANR-funded EffortLESS project (ANR-23-CE37-0014), led by Florian Monjo. These hypotheses were later refined and reformulated by Dr Lombardo in light of the emerging data.

Data acquisition was conducted at IRMGe, with the technical support and expertise of the research engineering team, whose contributions were essential to the success of the imaging protocol.

The data is provided in .mat format to support reuse and facilitate analysis. All fMRI data were preprocessed using FSL, including ICA-based denoising, following the protocol described in Griffanti et al. (2016). Spatial normalization was performed by first registering functional data to each subject’s T1-weighted anatomical image and then transforming to MNI-152 standard space.

Preprocessing Pipeline:





Motion correction




Spatial smoothing




Co-registration to individual T1-weighted anatomy




Normalization to MNI-152 standard space




ICA-based denoising using manual component classification



Data Summary:





Subjects included: 44




Missing data: Subjects 1, 9, and 35 are not included. Subject 28 is flagged as an intensity outlier.




Tasks included:





Task 1: Control task




Task 2: Ischemia condition (INB)






Volumes per task scan: 184




Resting-state fMRI: Not included due to storage limitations



ROI Extraction:

Time series were extracted using the Harvard-Oxford cortical atlas (file: HarvardOxford-cort-maxprob-thr25-1mm.nii.gz), comprising 48 cortical brain regions. ROI time series were co-registered to MNI space for each subject. Signals from left and right hemispheres were averaged, as the study did not test lateralization effects. Each subject’s data is saved in a .mat file containing a 48 (ROIs) × 184 (time points) matrix representing the BOLD signal. The raw denoised fMRI time series and subject-specific atlas templates coregistered to each participant’s T1 image are stored in a private folder: https://sfri-sante.netexplorer.pro/docs/696. Due to Zenodo’s storage limitations, these files are not hosted there but can be shared upon request.

File naming convention:ROIs_sub_xx_taskn.mat





xx = subject ID (1 to 43)




n = task number (1 = Control, 2 = INB)



All subject files are stored in the “ROI_Task1Vs2” directory.

Included Files:





matfiles_fMRI_Effort_Less.zip: Contains all final .mat files (max 5 GB due to storage constraints)




Disregard remaining .mat scripts not essential in this folder the final version are in the GitHub bellow



Code and Reproducibility:All analysis scripts needed to reproduce the main results and figures are available on GitHub:https://github.com/diegomlombardo

 

Here is a  list of Harvard‑Oxford cortical Atlas labels:




ROI #
Region Name




1
Frontal Pole


2
Insular Cortex


3
Superior Frontal Gyrus


4
Middle Frontal Gyrus


5
Inferior Frontal Gyrus, Pars Triangularis


6
Inferior Frontal Gyrus, Pars Opercularis


7
Precentral Gyrus


8
Temporal Pole


9
Superior Temporal Gyrus, Anterior Division


10
Superior Temporal Gyrus, Posterior Division


11
Middle Temporal Gyrus, Anterior Division


12
Middle Temporal Gyrus, Posterior Division


13
Middle Temporal Gyrus, Temporooccipital Part


14
Inferior Temporal Gyrus, Anterior Division


15
Inferior Temporal Gyrus, Posterior Division


16
Inferior Temporal Gyrus, Temporooccipital Part


17
Postcentral Gyrus


18
Superior Parietal Lobule


19
Supramarginal Gyrus, Anterior Division


20
Supramarginal Gyrus, Posterior Division


21
Angular Gyrus


22
Lateral Occipital Cortex, Superior Division


23
Lateral Occipital Cortex, Inferior Division


24
Intracalcarine Cortex


25
Frontal Medial Cortex


26
Juxtapositional Lobule Cortex


27
Subcallosal Cortex


28
Paracingulate Gyrus


29
Cingulate Gyrus, Anterior Division


30
Cingulate Gyrus, Posterior Division


31
Precuneous Cortex


32
Cuneal Cortex


33
Frontal Orbital Cortex


34
Parahippocampal Gyrus, Anterior Division


35
Parahippocampal Gyrus, Posterior Division


36
Lingual Gyrus


37
Temporal Fusiform Cortex, Anterior Division


38
Temporal Fusiform Cortex, Posterior Division


39
Temporal Occipital Fusiform Cortex


40
Occipital Fusiform Gyrus


41
Frontal Operculum Cortex


42
Central Opercular Cortex


43
Parietal Operculum Cortex


44
Planum Polare


45
Heschl’s Gyrus


46
Planum Temporale


47
Supracalcarine Cortex


48
Occipital Pole




 

 

Reference:Griffanti L, Douaud G, Bijsterbosch J, Evangelisti S, Alfaro-Almagro F, Glasser MF, Duff EP, Fitzgibbon S, Westphal R, Carone D, Beckmann CF, Smith SM. Hand classification of fMRI ICA noise components. NeuroImage. 2017 Jul 1;154:188–205. https://doi.org/10.1016/j.neuroimage.2016.12.036