cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17639/nott.6636
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 39515

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 39515 (III) Source: VDRC Name: klg (1) Full name: klingon Also known as: l(3)rN712 Annotation symbol: CG6669 FlyBase ID: FBgn0017590 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6625
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 11605R2

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 11605R2 (III) Source: NIG Name: jbug (1) Full name: jitterbug Also known as: Annotation symbol: CG30092 FlyBase ID: FBgn0028371 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6624
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 27985

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 27985 (III) Source: Bloomington Name: lz Full name: lozenge Also known as: fs(1)M69, lozenge Annotation symbol: CG1689 FlyBase ID: FBgn0002576 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.322
title: Cortical predictors and correlates of cochlear implant outcome: a longitudinal study using functional near-infrared spectroscopy

description: This deposit contains the raw data obtained during Carly Anderson's PhD at the University of Nottingham and used in resulting publications. It contains neuroimaging data (functional near-infrared spectroscopy), speech perception data, and clinical characteristics of cochlear implant users.
DOI: 10.17639/nott.6243
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 8896R3

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 8896R3 (III) Source: NIG Name: 18w (1) Full name: 18 wheeler Also known as: Toll-2, tlr Annotation symbol: CG8896 FlyBase ID: FBgn0004364 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.350
title: Data for paper: Dispersive detection of radio-frequency dressed states, arxiv:1801.07016

description: We introduce a method to dispersively detect alkali atoms in radio-frequency dressed states. In particular, we use dressed detection to measure populations and population differences of atoms prepared in their clock states. Linear birefringence of the atomic medium enables atom number detection via polarisation homodyning, a form of common path interferometry. In order to achieve low technical noise levels, we perform optical sideband detection after adiabatic transformation of bare states into dressed states. The balanced homodyne signal then oscillates independently of field fluctuations at twice the dressing frequency, thus allowing for robust, phase-locked detection that circumvents low-frequency noise. Using probe pulses of two optical frequencies, we can detect both clock states simultaneously and obtain population difference as well as the total atom number. The scheme also allows for difference measurements by direct subtraction of the homodyne signals at the balanced detector, which should technically enable quantum noise limited measurements with prospects for the preparation of spin squeezed states. The method extends to other Zeeman sublevels and can be employed in a range of atomic clock schemes, atom interferometers, and other experiments using dressed atoms.
DOI: 10.17639/nott.6185
title: The Blue-Green Path to Urban Flood Resilience

description: Achieving urban flood resilience at local, regional and national levels requires a transformative change in planning, design and implementation of urban water systems. Flood risk, wastewater and stormwater management should be re-envisaged and transformed to: ensure satisfactory service delivery under flood, normal and drought conditions, and enhance and extend the useful lives of ageing grey assets by supplementing them with multi-functional Blue-Green infrastructure. The aim of the multidisciplinary Urban Flood Resilience (UFR) research project, which launched in 2016 and comprises academics from nine UK institutions, is to investigate how transformative change may be possible through a whole systems approach. UFR research outputs to date are summarised under three themes. Theme 1 investigates how Blue-Green and Grey (BG+G) systems can be co-optimised to offer maximum flood risk reduction, continuous service delivery and multiple co-benefits. Theme 2 investigates the resource capacity of urban stormwater and evaluates the potential for interoperability. Theme 3 focuses on the interfaces between planners, developers, engineers and beneficiary communities and investigates citizens’ interactions with BG+G infrastructure. Focussing on retrofit and new build case studies, UFR research demonstrates how urban flood resilience may be achieved through changes in planning, practice and policy to enable widespread uptake of BG+G infrastructure.
DOI: 10.17639/nott.368
title: A continuum damage model for transverse cracking in UD composites of linear viscoelastic behaviour by Fei Xu, I. Arthur Jones and Shuguang Li

description: Relates to a paper being submitted. The DOI will be entered when the paper has been published and a DOI assigned.
description: This deposit is in two parts and contains the raw data and results for research described in the manuscript A Continuum Damage Model for Transverse Cracking in UD Composites of Linear Viscoelastic Behaviour by Fei Xu, I. Arthur Jones and Shuguang Li, submitted to Composite Structures in August 2018
DOI: 10.17639/nott.6177
title: A Voigt effect based 3D vector magnetometer

description: We describe a method to dispersively detect all three vector components of an external magnetic field using alkali atoms based on the Voigt effect. Our method relies on measuring the linear birefringence of the radio frequency dressed atomic medium via polarization homodyning. This gives rise to modulated polarization signals at the first and second harmonic of the dressing frequency. The vector components of the external magnetic field are mapped onto the quadratures of these harmonics. We find that our scheme can be utilised in both cold and hot atomic gases to detect such external fields in shielded and unshielded environments. In the shielded hot vapour case we achieve field sensitivities well below 1~pT/√ Hz range for all 3 vector components, using pump-probe cycles with 125 Hz repetition rate, and limited by the short coherence time of the cell. Finally, our scheme has a simple single axis beam geometry making it advantageous for miniature magnetic field sensors.
DOI: 10.17639/nott.7003
title: VisitorBox core deck

description: A digital copy of the core deck of ideation cards created during the VisitorBox project. The cards have been developed as a result of prototyping workshops with museums and galleries, and will be released as an open resource upon project completion. The cards can be used to develop ideas for new visitor experiences, and for evaluating existing visitor experiences.
DOI: 10.17639/nott.6188
title: Two-dimensional diffusion of excitons in a perylene diimide monolayer quenched by a fullerene heterojunction

description: The structural and functional properties of organic heterojunctions play a vitally important role in the operation of organic devices, but their properties are difficult to measure directly due to the buried interfaces which are typically formed. We have grown model heterojunctions consisting of two monolayer-thick organic semiconductors, and to use these bilayers to explore the two-dimensional dynamics of excitons. The heterostructures are formed by sequential deposition of monolayers of perylene-3,4,9,10-tetracarboxylic-3,4,9,10-diimide (PTCDI) and fullerene (C60) on hexagonal boron nitride (hBN). The morphology of these bilayers was characterized using atomic force microscopy and showed clear differences in the C60 growth kinetics on hBN and PTCDI. The variation in the fluorescence of PTCDI-C60 heterostructures with increasing fullerene coverage showed a reduction in intensity consistent with exciton diffusion and quenching. We use a simple model for the intensity dependence to determine the two-dimensional exciton diffusion length in a PTCDI monolayer finding a value of 17 ± 3 nm for this parameter.
DOI: 10.17639/nott.6999
title: 1Hz GPS Japan network (GEONET) data for Tohoku-Oki Mw9.0 2011 earthquake

description: The GNSS network of Japan, which is known as GNSS Earth Observatoin Network System (GEONET-Japan) and operated by the Geospatial Information Authority of Japan, consists of more than 1200 continuously observing GNSS stations, covering the Japanese land area with 20 km average distance between neighborouring GNSS sites. The Mw9.0 earthquake of Tohoku on 2011 March 11 was fully recorded by GEONET and GPS records of 847 GEONET stations of 15-hour duration and 1 Hz sampling rate, covering the period of the earthquake, were available. The GPS records have been processed using the scientific Bernese GPS Software 5.2 in post-process Precise Point Positioning mode using a priori information of highest quality from the Center of Orbit Determination in Europe (CODE). This dataset is the 1 Hz GPS coordinate time-series, as the result of the post-process solution, in north, east and up components. The 1 Hz GPS time-series cover 7-hour period prior, during and after the Tohoku Mw9.0 2011 earthquake.
DOI: 10.17639/nott.7006
title: Connected Everything Industry Interviews : Priorities for Digital Manufacturing

description: To ascertain industry perspectives on digital manufacturing in the UK, and thereby identify fundamental and applied research challenges in digital manufacturing which will enable the acceleration of improvement in productivity.
DOI: 10.17639/nott.16
title: Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation - Supporting data 2

description: A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. Data presented here shows cell adhesion to microarrays, scaled up surfaces, pluripotent marker expression and multilineage differentiation markers. Please note that this data set is in two parts, the first part of which can be found here: http://doi.org/10.17639/nott.12
DOI: 10.17639/nott.60
title: Learning and Action Alliance framework to facilitate stakeholder collaboration and social learning in urban flood risk management

description: Flood and water management governance may be enhanced through partnership working, intra- and cross-organisational collaborations, and wide stakeholder participation. Nonetheless, barriers associated with ineffective communication, fragmented responsibilities and ‘siloed thinking’ restrict open dialogue and discussion. The Learning and Action Alliance (LAA) framework may help overcome these barriers by enabling effective engagement through social learning, and facilitating targeted actions needed to deliver innovative solutions to environmental problems. By increasing the adaptive capacity of decision-makers and participants, social learning through LAAs may lead to concerted action and sustained processes of behavioural change. In this paper, we evaluate the LAA framework as a catalyst for change that supports collaborative working and facilitates transition to more sustainable flood risk management. We use a case study in Newcastle-upon-Tyne, UK, to demonstrate how the LAA framework brought together disparate City stakeholders to co-produce new knowledge, negotiate innovative actions and, ultimately, work towards implementing a new vision for sustainable urban flood risk management. The shared vision of Newcastle as a ‘Blue-Green City’ that emerged is founded on a strong platform for social learning which increased organisations’ and individuals’ capacities to manage differences in perspectives and behaviours, reframe knowledge, and make collective decisions based on negotiation and conflict resolution. Broad recommendations based on lessons learned from the Newcastle LAA are presented to aid other cities and regions in establishing and running social learning platforms.
DOI: 10.17639/nott.7013
title: Survey of L2 English CMC activities

description: This data set contains the data collected from a survey run in collaboration between Andrew Moffat at the University of Nottingham, and Cambridge University Press. The data were collected using a questionnaire hosted on Bristol Online Surveys, with respondents recruited by means of a banner on CUP's online dictionary website. The data were collected as part of a PhD research project looking at L2 English CMC usage habits.
DOI: 10.17639/nott.376
title: The Adsorption of hexacontane on hexagonal boron nitride

description: We have investigated the adsorption of hexacontane (C60 H122) on hexagonal boron nitride (hBN) using atomic force microscopy (AFM). The molecules can be deposited either by sublimation or from solution and form lamellar rows with dimensions of the order of 0.1 - 1 µm in three different rotational domains. High-resolution AFM images reveal that, similar to alkanes on graphite, the molecules are adsorbed parallel to the lattice vectors of hBN and we show using molecular mechanics that this corresponds to the lowest energy configuration. Lamellar rows with the same periodicity are observed even when several layers of hexacontane are deposited, although there is some orientational disorder in these multilayers. We also observe heat-induced modification of hexacontane including re-crystallization. We compare our results with recent X-ray studies of alkane adsorption on hBN and discuss the possible role of alkanes on steering molecular self-assembly on hBN.
DOI: 10.17639/nott.58
title: 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling
title: ToF-SIMS of hydrogels

description: Data storage of 3 ToF-SIMS depth profiles of frozen-hydrated hydrogels as required by the EPSRC data deposit requirement
DOI: 10.17639/nott.36
title: Multiple rainfall event pollution transport by Sustainable Drainage Systems: the fate of fine sediment pollution

description: A key design criterion of sustainable urban drainage systems is to mitigate urban stormwater pollution. Current research defines sustainable urban drainage systems (SuDS) pollutant treatment efficiency through the detention of total suspended solids, urban nutrients and heavy metal pollutants within the system during a design flow event, with research focusing on sand (&gt;2mm) sediment movement. The impact of multiple rainfall-runoff events on the fine sediment (&lt;2mm) treatment efficiency of SuDS is not yet well defined and the temporal movement of detained sediment has not been investigated in detail. The field research presented in this paper addresses this research gap, monitoring ongoing fine sediment transport through a best practice designed SuDS network over 12 months through the use of a novel rare earth oxide (REO) trace methodology. Through time-stepped monitoring of the fine sediment pollution across three SuDS treatment trains (networks), the following key conclusions have been drawn. (1) That fine sediment becomes re-suspended and re-deposited within SuDS assets and the network as a result of ongoing multiple rainfall-runoff events. (2) That this re-suspension continues for over 52 weeks. (3) That by area, linear wetlands (within the monitored networks) out-perform wetland and swale assets in multiple event fine sediment detention. And (4) that multiple event monitoring and analysis of fine sediment within a SuDS network highlights the under-performance of SuDS assets against current design event expectations.
DOI: 10.17639/nott.7015
title: Effects of GNSS receiver tuning on the PLL tracking jitter estimation in the presence of ionospheric scintillation

description: This file is used to simulate GPS scintillation data using a Spirent GNSS simulator.
DOI: 10.17639/nott.14
title: Compounding and rheometry of PLA nanocomposites with coated and uncoated hydroxyapatite nanoplatelets

description: This is the research data for polylactic acid and novel nanoplatelets of hydroxyapatite (HANP) that were compounded in a laboratory scale twin-screw extruder and injection moulded to shape. The effect of HANP loading content, between 1 wt% and 10 wt%, and of HANP surface coating with tailored molecular dispersants, on processability and rheological behaviour were investigated. Dispersion of HANP within the matrix system was determined qualitatively using transmission electron micrographs. Surface coating of HANP with dispersants was observed to change the state of HANP dispersion in the nanocomposites. This was also reflected in the changes of the nanocomposites’ rheological response at lower frequencies
DOI: 10.17639/nott.335
title: Numerical modelling of hydro-morphological processes dominated by fine suspended sediment in a stormwater pond

description: Fine sediment plays crucial and multiple roles in the hydrological, ecological and geomorphological functioning of river systems. This study employs a two-dimensional (2D) numerical model to track the hydro-morphological processes dominated by fine suspended sediment, including the prediction of sediment concentration in flow bodies, and erosion and deposition caused by sediment transport. The model is governed by 2D full shallow water equations with which an advection-diffusion equation for fine sediment is coupled. Bed erosion and sedimentation are updated by a bed deformation model based on local sediment entrainment and settling flux in flow bodies. The model is initially validated with the three laboratory-scale experimental events where suspended load plays a dominant role. Satisfactory simulation results confirm the model’s capability in capturing hydro-morphodynamic processes dominated by fine suspended sediment at laboratory-scale. Applications to sedimentation in a stormwater pond are conducted to develop the process-based understanding of fine sediment dynamics over a variety of flow conditions. Urban flows with 5-year, 30-year and 100-year return period and the extreme flood event in 2012 are simulated. The modelled results deliver a step change in understanding fine sediment dynamics in stormwater ponds. The model is capable of quantitatively simulating and qualitatively assessing the performance of a stormwater pond in managing urban water quantity and quality.
DOI: 10.17639/nott.7027
title: “A Permanent National Necessity...” Adult Education and Lifelong Learning for 21st Century Britain
title: Report of the Centenary Commission on Adult Education

description: Report of the Centenary Commission on Adult Education (2019); chair: Dame Helen Ghosh. The Commission was set up by the Adult Education 100 campaign to mark the centenary of the Final Report (1919) of the Ministry of Reconstruction's Adult Education Committee. The Centenary Commission's purpose was to set a vision for adult education in Great Britain in the 21st century.