cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7072685
title: Supplementary Material for: Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with <b><i>Bifidobacterium</i></b> Colonization

description: <b><i>Background:</i></b> Altered regulatory immune responses to microbial stimuli and intestinal colonization of beneficial bacteria early in life may contribute to the development of allergic diseases (e.g., atopic dermatitis [AD]). However, few reports have investigated these factors simultaneously. The purpose of this study was to analyze neonatal immune responses to microbial stimuli as well as intestinal colonization of beneficial bacteria, in relation to the development of AD in a birth cohort. <b><i>Methods:</i></b> Pregnant women were recruited, and their infants were followed up until 7 months of age. Levels of interleukin (IL)-10 released from cord-blood mononuclear cells (CBMCs) stimulated with heat-killed gram-positive bacteria (<i>Bifidobacterium bifidum</i> and <i>Lactobacillus rhamnosus</i> GG) and <i>Lactobacillus</i>-derived peptidoglycan were measured. Fecal<i> Bifidobacterium</i> counts at 4 days and 1 month were quantified using real-time polymerase chain reaction. The development of AD was determined by means of a questionnaire at 7 months of age. <b><i>Results:</i></b> The levels of released IL-10 were significantly lower in infants with AD (<i>n</i> = 17) than in infants without AD (<i>n</i> = 53) for all stimuli. In infants with fecal <i>Bifidobacterium</i>, the incidence of AD was inversely associated with the release of IL-10 from cord blood mononuclear cells. <b><i>Conclusion:</i></b> Our findings suggest that impaired IL-10 production in response to microbial stimuli at birth may be associated with an increased risk of developing infantile AD, even in infants with early colonization of intestinal bifidobacteria.
DOI: 10.6084/m9.figshare.7072700
title: Supplementary Material for: Bilirubin Production Is Increased in Newborn Mice Exposed to Isoflurane

description: <b><i>Background:</i></b> Increased bilirubin production due to hemolysis can lead to severe neonatal hyperbilirubinemia and, if left untreated, to bilirubin neurotoxicity. Post-cardiac surgery newborns have been shown to be at an increased risk for developing hyperbilirubinemia and also hemolysis. Isoflurane (ISO), a volatile anesthetic agent routinely used in newborn surgery, has been reported to upregulate heme oxygenase 1 (HO-1) expression. HO is the rate-limiting enzyme in the bilirubin production pathway. <b><i>Objective:</i></b> Here, we evaluated whether ISO exposure induces HO-1 and further increases bilirubin production in a hemolytic newborn mouse model. <b><i>Methods:</i></b> Three-day-old newborn mice were exposed to 2% ISO for 18 min or air. Liver HO activity and HO-1 protein were measured after exposure to ISO. Next, we evaluated the effect of ISO exposure on bilirubin production as indexed by the total body excretion rate of carbon monoxide following heme loading. <b><i>Results:</i></b> ISO significantly increased liver HO activity 120% and 116% at 24 and 48 h, respectively, after exposure. HO-1 protein levels also similarly increased after ISO exposure, but the increases were not statistically significant compared with controls. After heme loading, ISO-exposed pups had significantly higher bilirubin production rates (1.24-fold), and also peaked earlier, than age-matched nonexposed pups. <b><i>Conclusions:</i></b> ISO exposure can induce HO-1 expression in the liver and may explain the development of severe hyperbilirubinemia in postsurgical infants, especially in those undergoing hemolysis.
DOI: 10.6084/m9.figshare.7072685.v1
title: Supplementary Material for: Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with <b><i>Bifidobacterium</i></b> Colonization

description: <b><i>Background:</i></b> Altered regulatory immune responses to microbial stimuli and intestinal colonization of beneficial bacteria early in life may contribute to the development of allergic diseases (e.g., atopic dermatitis [AD]). However, few reports have investigated these factors simultaneously. The purpose of this study was to analyze neonatal immune responses to microbial stimuli as well as intestinal colonization of beneficial bacteria, in relation to the development of AD in a birth cohort. <b><i>Methods:</i></b> Pregnant women were recruited, and their infants were followed up until 7 months of age. Levels of interleukin (IL)-10 released from cord-blood mononuclear cells (CBMCs) stimulated with heat-killed gram-positive bacteria (<i>Bifidobacterium bifidum</i> and <i>Lactobacillus rhamnosus</i> GG) and <i>Lactobacillus</i>-derived peptidoglycan were measured. Fecal<i> Bifidobacterium</i> counts at 4 days and 1 month were quantified using real-time polymerase chain reaction. The development of AD was determined by means of a questionnaire at 7 months of age. <b><i>Results:</i></b> The levels of released IL-10 were significantly lower in infants with AD (<i>n</i> = 17) than in infants without AD (<i>n</i> = 53) for all stimuli. In infants with fecal <i>Bifidobacterium</i>, the incidence of AD was inversely associated with the release of IL-10 from cord blood mononuclear cells. <b><i>Conclusion:</i></b> Our findings suggest that impaired IL-10 production in response to microbial stimuli at birth may be associated with an increased risk of developing infantile AD, even in infants with early colonization of intestinal bifidobacteria.
DOI: 10.6084/m9.figshare.7072700.v1
title: Supplementary Material for: Bilirubin Production Is Increased in Newborn Mice Exposed to Isoflurane

description: <b><i>Background:</i></b> Increased bilirubin production due to hemolysis can lead to severe neonatal hyperbilirubinemia and, if left untreated, to bilirubin neurotoxicity. Post-cardiac surgery newborns have been shown to be at an increased risk for developing hyperbilirubinemia and also hemolysis. Isoflurane (ISO), a volatile anesthetic agent routinely used in newborn surgery, has been reported to upregulate heme oxygenase 1 (HO-1) expression. HO is the rate-limiting enzyme in the bilirubin production pathway. <b><i>Objective:</i></b> Here, we evaluated whether ISO exposure induces HO-1 and further increases bilirubin production in a hemolytic newborn mouse model. <b><i>Methods:</i></b> Three-day-old newborn mice were exposed to 2% ISO for 18 min or air. Liver HO activity and HO-1 protein were measured after exposure to ISO. Next, we evaluated the effect of ISO exposure on bilirubin production as indexed by the total body excretion rate of carbon monoxide following heme loading. <b><i>Results:</i></b> ISO significantly increased liver HO activity 120% and 116% at 24 and 48 h, respectively, after exposure. HO-1 protein levels also similarly increased after ISO exposure, but the increases were not statistically significant compared with controls. After heme loading, ISO-exposed pups had significantly higher bilirubin production rates (1.24-fold), and also peaked earlier, than age-matched nonexposed pups. <b><i>Conclusions:</i></b> ISO exposure can induce HO-1 expression in the liver and may explain the development of severe hyperbilirubinemia in postsurgical infants, especially in those undergoing hemolysis.
DOI: 10.26165/juelich-data/tvwuup/toduub
title: 578.png

description: :unav
DOI: 10.26165/juelich-data/tvwuup/73nush
title: 702.png

description: :unav
DOI: 10.26165/juelich-data/tvwuup/hzfjzs
title: 636.png

description: :unav
DOI: 10.6084/m9.figshare.7072643
title: Supplementary Material for: A Time-Series Analysis of Severe Burned Injury of Skin Gene Expression Profiles

description: <b><i>Background/Aims:</i></b> Major burn injury is one of the main severe forms of wound which lead to a mass of clinical debilitation, this study was to identify core biomarkers for the recovery of severe burned injury. <b><i>Methods:</i></b> Gene expression profiles (GSE19743) from the Gene Expression Omnibus (GEO) was downloaded, followed by background correction, normalization of raw microarray dataset and identification of differential expression genes (DEGs) . Soft clustering of DEGs was used for the screening of gene clusters that with sustained increasing (SIG) and decreasing expression (SDG) profiles along with the recovery process of burned injury. The significantly enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of SIGs and SDGs were obtained through the Database for Annotation, Visualization, and Integrated Discovery (DAVID), based on which the miRNA-gene regulation network for SIGs and SDGs were constructed from the miRWalk database. <b><i>Results:</i></b> Ten clusters were obtained through soft clustering. The SIGs and SDGs were found to be closely associated with the biological processes of immune system. The miRNA-gene regulation network analysis suggested different roles between SIGs and SDGs in the recovery of severe burned injury. Furthermore, a bunch of important biomarkers were identified, which would be helpful in the treatment of burned patients. <b><i>Conclusion</i></b><b><i>:</i></b> Our current findings suggest an interesting molecular link between transcriptional regulation potentially involved in immunosuppressive state after major burn injury, which warrants further exploration for their utilization in the treatment of major burn injury.
DOI: 10.26165/juelich-data/tvwuup/wbzqdj
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description: :unav
DOI: 10.25377/sussex.7072634
title: Research data for paper: Team Level Identification Predicts Perceived and Actual Team Performance: Longitudinal Multilevel Analyses with Sports Teams.

description: <b>Data for paper appearing in British Journal of Social Psychology Sept 2018</b><br><br>Team Performance and Social Identity Longitudinal Data Set<br>Longitudinal, multilevel team performance and social identity data set<br>A copy of SPSS software is required to download and view this data.<br><b>Abstract</b>Social identification and team performance literatures typically focus on the relationship between individual differences in identification and individual‐level performance. By using a longitudinal multilevel approach, involving 369 members of 45 sports teams across England and Italy, we compared how team‐level and individual‐level variance in social identification together predicted team and individual performance outcomes. As hypothesized, team‐level variance in identification significantly predicted subsequent levels of both perceived and actual team performance in cross‐lagged analyses. Conversely, individual‐level variance in identification did not significantly predict subsequent levels of perceived individual performance. These findings support recent calls for social identity to be considered a multilevel construct and highlight the influence of group‐level social identification on group‐level processes and outcomes, over and above its individual‐level effects.<br>
DOI: 10.25377/sussex.7072634.v1
title: Research data for paper: Team Level Identification Predicts Perceived and Actual Team Performance: Longitudinal Multilevel Analyses with Sports Teams.

description: <b>Data for paper appearing in British Journal of Social Psychology Sept 2018</b><br><br>Team Performance and Social Identity Longitudinal Data Set<br>Longitudinal, multilevel team performance and social identity data set<br>A copy of SPSS software is required to download and view this data.<br><b>Abstract</b>Social identification and team performance literatures typically focus on the relationship between individual differences in identification and individual‐level performance. By using a longitudinal multilevel approach, involving 369 members of 45 sports teams across England and Italy, we compared how team‐level and individual‐level variance in social identification together predicted team and individual performance outcomes. As hypothesized, team‐level variance in identification significantly predicted subsequent levels of both perceived and actual team performance in cross‐lagged analyses. Conversely, individual‐level variance in identification did not significantly predict subsequent levels of perceived individual performance. These findings support recent calls for social identity to be considered a multilevel construct and highlight the influence of group‐level social identification on group‐level processes and outcomes, over and above its individual‐level effects.<br>
DOI: 10.26165/juelich-data/tvwuup/i3gf1p
title: 416.png

description: :unav
DOI: 10.6084/m9.figshare.7072631
title: Eemian dataset - Test embargo

description: This is a test embargoed data of a pollen sequence of the Eemian (not real)
DOI: 10.6084/m9.figshare.7072601
title: Unraveling structural requirements of amino-pyrimidine T790M/L858R double mutant EGFR inhibitors: 2D and 3D QSAR study

description: EGFR is an important drug target in cancer. However, the ineffectiveness of first generation inhibitors due to the occurrence of a secondary mutation (T790M) results in the relapse of the disease. Identification of reversible inhibitors against T790M/L858R double mutants (TMLR) thus is a foremost requirement. In this study, various 2 D and 3 D Quantitative Structure–Activity Relationship models were built for amino-pyrimidine compounds with their known biological activity against TMLR mutants. The model developed using multiple linear regression statistical method via stepwise forward-backward variable selection technique showed the best results in terms of internal and external predictivity. The 2D-QSAR model indicated that the presence of electronegative atom, H-bond donors, moderate slogp, count of number of N atoms separated from O (T_N_O_4), 4pathClusterCount and number of S atom connected with two single bonds (SssSE-index), is required for increasing the inhibitory potential of compounds. Also, the 3D-QSAR model suggested that electronegative group at certain positions along with the presence of bulky groups is beneficial for good inhibition activity of the compounds. Thus, the QSAR models developed in the present work can be used for predicting the TMLR bioactivity of a new series of amino-pyrimidine derivatives. To the best of the author’s knowledge, this is the first study which deals with the development of 2 D and 3D-QSAR models for double mutant TMLR inhibitors.
DOI: 10.6084/m9.figshare.7072631.v1
title: Eemian dataset - Test embargo

description: This is a test embargoed data of a pollen sequence of the Eemian (not real)
DOI: 10.26165/juelich-data/tvwuup/sj3sul
title: 622.png

description: :unav
DOI: 10.6084/m9.figshare.7072601.v1
title: Unraveling structural requirements of amino-pyrimidine T790M/L858R double mutant EGFR inhibitors: 2D and 3D QSAR study

description: EGFR is an important drug target in cancer. However, the ineffectiveness of first generation inhibitors due to the occurrence of a secondary mutation (T790M) results in the relapse of the disease. Identification of reversible inhibitors against T790M/L858R double mutants (TMLR) thus is a foremost requirement. In this study, various 2 D and 3 D Quantitative Structure–Activity Relationship models were built for amino-pyrimidine compounds with their known biological activity against TMLR mutants. The model developed using multiple linear regression statistical method via stepwise forward-backward variable selection technique showed the best results in terms of internal and external predictivity. The 2D-QSAR model indicated that the presence of electronegative atom, H-bond donors, moderate slogp, count of number of N atoms separated from O (T_N_O_4), 4pathClusterCount and number of S atom connected with two single bonds (SssSE-index), is required for increasing the inhibitory potential of compounds. Also, the 3D-QSAR model suggested that electronegative group at certain positions along with the presence of bulky groups is beneficial for good inhibition activity of the compounds. Thus, the QSAR models developed in the present work can be used for predicting the TMLR bioactivity of a new series of amino-pyrimidine derivatives. To the best of the author’s knowledge, this is the first study which deals with the development of 2 D and 3D-QSAR models for double mutant TMLR inhibitors.
DOI: 10.26165/juelich-data/tvwuup/3l2oqf
title: 025.png

description: :unav
DOI: 10.6084/m9.figshare.7072568
title: Concreteness and emotional valence of episodic future thinking (EFT) independently affect the dynamics of intertemporal decisions

description: During intertemporal decisions, the value of future rewards decreases as a function of the delay of its receipt (temporal discounting, TD). Since high discount rates have been associated with a series of problematic behaviours and clinical conditions, current research has focused on possible modulators of TD. Specifically, a reduction of individual discount rates has been shown during episodic future thinking (EFT), wherein time intervals are anchored to personal future events. However, it is not entirely clear whether this effect is mediated by a change in the representation of future events (i.e., from abstract to concrete) or by a positive-emotion modulation. Here, we investigated this issue by manipulating the valence of the EFT (i.e., using negative, neutral and positive episodic tags), and by collecting explicit and implicit measures of behaviour. The results showed a significant reduction of TD in all the three emotional conditions compared to the baseline, with differences among them, thus suggesting the existence of a cumulative effect of the concreteness and affective components of the EFT. The analyses of implicit measures additionally revealed that this effect was mediated by a simultaneous increase/decrease of attraction toward the delayed/immediate alternative. Finally, these effects appeared to be modulated by participants' baseline discounting preferences. These findings provide important insights on clinical applications in reward-related disorders.<br>
DOI: 10.26165/juelich-data/tvwuup/ne2nyu
title: 006.png

description: :unav
DOI: 10.6084/m9.figshare.7072568.v1
title: Concreteness and emotional valence of episodic future thinking (EFT) independently affect the dynamics of intertemporal decisions

description: During intertemporal decisions, the value of future rewards decreases as a function of the delay of its receipt (temporal discounting, TD). Since high discount rates have been associated with a series of problematic behaviours and clinical conditions, current research has focused on possible modulators of TD. Specifically, a reduction of individual discount rates has been shown during episodic future thinking (EFT), wherein time intervals are anchored to personal future events. However, it is not entirely clear whether this effect is mediated by a change in the representation of future events (i.e., from abstract to concrete) or by a positive-emotion modulation. Here, we investigated this issue by manipulating the valence of the EFT (i.e., using negative, neutral and positive episodic tags), and by collecting explicit and implicit measures of behaviour. The results showed a significant reduction of TD in all the three emotional conditions compared to the baseline, with differences among them, thus suggesting the existence of a cumulative effect of the concreteness and affective components of the EFT. The analyses of implicit measures additionally revealed that this effect was mediated by a simultaneous increase/decrease of attraction toward the delayed/immediate alternative. Finally, these effects appeared to be modulated by participants' baseline discounting preferences. These findings provide important insights on clinical applications in reward-related disorders.<br>
DOI: 10.26165/juelich-data/tvwuup/dwhq37
title: 650.png

description: :unav
DOI: 10.6084/m9.figshare.7072532
title: RNA-sequencing transcriptome data of Laodelphax striatellus

description: To determine how <i>LsFoxO</i> affects nymphal diapause, analyses of RNA-sequencing transcriptome data after treatment with <i>LsFoxO</i>–RNA interference was performed
DOI: 10.26165/juelich-data/tvwuup/2nhewm
title: 503.png

description: :unav
DOI: 10.6084/m9.figshare.7072532.v1
title: RNA-sequencing transcriptome data of Laodelphax striatellus

description: To determine how <i>LsFoxO</i> affects nymphal diapause, analyses of RNA-sequencing transcriptome data after treatment with <i>LsFoxO</i>–RNA interference was performed
DOI: 10.26165/juelich-data/tvwuup/5vqozt
title: 475.png

description: :unav
DOI: 10.6084/m9.figshare.7072511
title: Lizard and Frog MiSeq Sequences

description: Illumina MiSeq sequences from three lizard and six frog species, 10 samples per species, from near the campus of Charles Darwin University, Australia. Sequence data correspond with "lizardfrog_metadata." Sequences demultiplexed and chimeras removed.
DOI: 10.6084/m9.figshare.7072511.v1
title: Lizard and Frog MiSeq Sequences

description: Illumina MiSeq sequences from three lizard and six frog species, 10 samples per species, from near the campus of Charles Darwin University, Australia. Sequence data correspond with "lizardfrog_metadata." Sequences demultiplexed and chimeras removed.
DOI: 10.26165/juelich-data/tvwuup/p2zozo
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DOI: 10.26165/juelich-data/tvwuup/pvh6aw
title: 454.png

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DOI: 10.26165/juelich-data/tvwuup/mjms4a
title: 303.png

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DOI: 10.26165/juelich-data/tvwuup/f0du8i
title: 160.png

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DOI: 10.26165/juelich-data/tvwuup/5oet4d
title: 634.png

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DOI: 10.26165/juelich-data/tvwuup/5cpamr
title: 200.png

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DOI: 10.26165/juelich-data/tvwuup/todjrn
title: 404.png

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DOI: 10.26165/juelich-data/tvwuup/lcjumy
title: 254.png

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DOI: 10.26165/juelich-data/tvwuup/si9m6v
title: 364.png

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DOI: 10.26165/juelich-data/tvwuup/xuf00p
title: 293.png

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DOI: 10.26165/juelich-data/tvwuup/dzmpjn
title: 077.png

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DOI: 10.26165/juelich-data/tvwuup/yvhx6i
title: 175.png

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DOI: 10.26165/juelich-data/tvwuup/96zuca
title: 052.png

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DOI: 10.26165/juelich-data/tvwuup/qdch08
title: 491.png

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DOI: 10.26165/juelich-data/tvwuup/k8hwdn
title: 280.png

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DOI: 10.26165/juelich-data/tvwuup/dw0aob
title: 289.png

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DOI: 10.26165/juelich-data/tvwuup/t56blr
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DOI: 10.26165/juelich-data/tvwuup/ydqcly
title: 155.png

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DOI: 10.26165/juelich-data/tvwuup/gg2fvw
title: 118.png

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DOI: 10.26165/juelich-data/tvwuup/x4u9u6
title: 643.png

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DOI: 10.26165/juelich-data/tvwuup/o1vywn
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DOI: 10.26165/juelich-data/tvwuup/0oigwq
title: 363.png

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DOI: 10.26165/juelich-data/tvwuup/t6jrzo
title: 514.png

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DOI: 10.26165/juelich-data/tvwuup/um8woy
title: 661.png

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DOI: 10.26165/juelich-data/tvwuup/l9hll6
title: 705.png

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DOI: 10.26165/juelich-data/tvwuup/cc8zgw
title: 348.png

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DOI: 10.26165/juelich-data/tvwuup/iqrupa
title: 191.png

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DOI: 10.26165/juelich-data/tvwuup/jxoxqg
title: 282.png

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DOI: 10.26165/juelich-data/tvwuup/xjyzkh
title: 109.png

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DOI: 10.26165/juelich-data/tvwuup/qmkg1t
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DOI: 10.26165/juelich-data/tvwuup/rsfloc
title: 432.png

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DOI: 10.26165/juelich-data/tvwuup/wch6zs
title: 619.png

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DOI: 10.26165/juelich-data/tvwuup/akf1qd
title: 445.png

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DOI: 10.26165/juelich-data/tvwuup/4feyuj
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DOI: 10.26165/juelich-data/tvwuup/avxfgh
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DOI: 10.26165/juelich-data/tvwuup/vinszh
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DOI: 10.26165/juelich-data/tvwuup/4rhwln
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DOI: 10.26165/juelich-data/tvwuup/zuf1oh
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DOI: 10.26165/juelich-data/tvwuup/drpi0m
title: 270.png

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DOI: 10.26165/juelich-data/tvwuup/ots6xu
title: 431.png

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