cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30404899.v1
title: Supplementary Material for: INVITATION 20 - Association of outdoor allergens with respiratory allergic diseases: a systematic review

description: Introduction: The global burden of respiratory allergic diseases linked to outdoor allergens remains poorly quantified despite increasing evidence of the allergens’ impacts on respiratory allergic diseases. This systematic review synthesizes epidemiological evidence on the association between exposure to outdoor airborne allergens and respiratory disease incidence. 
Methods: Following PRISMA 2020 guidelines, we systematically searched three databases, PubMed, Embase, and the Cochrane Library, until December 2024. Observational studies reporting effect estimates for respiratory outcomes (asthma, allergic rhinitis, COPD exacerbations and cough) associated with quantified outdoor allergen exposure were eligible. Two reviewers independently conducted screening, data extraction, and quality assessment using an adapted Newcastle-Ottawa Scale. Random-effects models were employed to pool odds ratios (ORs), with subgroup analyses by sex. Publication bias were evaluated using Begg’s and Egger's tests, respectively. 
Results: From 6,551 identified records, 7 articles with 67 studies ( 46325 participants across 3 countries) met inclusion criteria. High-quality studies (NOS ≥7) constituted 86% of included articles. Pooled analyses revealed significant associations between outdoor allergen exposure and respiratory outcomes: OR=1.04 (95% CI: 1.02-1.06; P=0.008). Egger’s publication bias was non-significant (Egger's P=0.21), and Begg’s publication bias was also non-significant (Begg’s P=0.31). Trim-and-fill funnel plots suggested possible missing small-null studies, but the statistical analysis was non-significant. Sensitivity analyses confirmed robustness when excluding studies with potential residual confounding ( pooled OR range: 1.02-1.06). Subgroup analyses demonstrated female subgroup rather than male subgroup got stronger effects significantly: OR=1.04 (95% CI: 1.01-1.07), compared with male subgroup OR=1.02 (95% CI: 0.99-1.04). 
Conclusions: This comprehensive synthesis provides high-quality evidence that outdoor allergen exposure significantly increases risks of respiratory morbidity. The female is more likely to get respiratory morbidity compared with the male. Further research should prioritize harmonized exposure metrics and evaluate interactive effects with anthropogenic air pollutants.
DOI: 10.5517/ccx2414
title: CCDC 836195: Experimental Crystal Structure Determination

description: Related Article: Y.M.Badiei, M.A.Siegler, D.P.Goldberg|2011|J.Am.Chem.Soc.|133|1274|doi:10.1021/ja109923a
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccx2425
title: CCDC 836196: Experimental Crystal Structure Determination

description: Related Article: Y.M.Badiei, M.A.Siegler, D.P.Goldberg|2011|J.Am.Chem.Soc.|133|1274|doi:10.1021/ja109923a
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccvwcxz
title: CCDC 800882: Experimental Crystal Structure Determination

description: Related Article: Xiaochen Cai, S.Majumdar, G.C.Fortman, C.S.J.Cazin, A.M.Z.Slawin, C.Lhermitte, R.Prabhakar, M.E.Germain, T.Palluccio, S.P.Nolan, E.V.Rybak-Akimova, M.Temprado, B.Captain, C.D.Hoff|2011|J.Am.Chem.Soc.|133|1290|doi:10.1021/ja1103348
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccvwcy0
title: CCDC 800883: Experimental Crystal Structure Determination

description: Related Article: Xiaochen Cai, S.Majumdar, G.C.Fortman, C.S.J.Cazin, A.M.Z.Slawin, C.Lhermitte, R.Prabhakar, M.E.Germain, T.Palluccio, S.P.Nolan, E.V.Rybak-Akimova, M.Temprado, B.Captain, C.D.Hoff|2011|J.Am.Chem.Soc.|133|1290|doi:10.1021/ja1103348
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccx2447
title: CCDC 836198: Experimental Crystal Structure Determination

description: Related Article: G.Villar-Acevedo, E.Nam, S.Fitch, J.Benedict, J.Freudenthal, W.Kaminsky, J.A.Kovacs|2011|J.Am.Chem.Soc.|133|1419|doi:10.1021/ja107551u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccx2458
title: CCDC 836199: Experimental Crystal Structure Determination

description: Related Article: G.Villar-Acevedo, E.Nam, S.Fitch, J.Benedict, J.Freudenthal, W.Kaminsky, J.A.Kovacs|2011|J.Am.Chem.Soc.|133|1419|doi:10.1021/ja107551u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cctq2yj
title: CCDC 766008: Experimental Crystal Structure Determination

description: Related Article: V.I.Tsaryuk, K.P.Zhuravlev, A.V.Vologzhanina, V.A.Kudryashova, V.F.Zolin|2010|J.Photochem.Photobiol.A:Chem.|211|7|doi:10.1016/j.jphotochem.2010.01.012
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30404902
title: Supplementary Material for: Circulating Plasmacytoid Dendritic Cells are Numerically and Functionally Deficient in Trauma Patients

description: Introduction: Dendritic cells (DCs) are crucial in immune responses but their roles in trauma patients remain poorly understood. This study aimed to investigate the frequencies and functions of plasmacytoid DCs (pDCs) and conventional DCs (cDCs) in trauma patients.
Methods: This study included 25 trauma patients and 40 healthy controls. Using flow cytometry, the frequencies, cytokine production (IFN-α, TNF-α, IL-12), and expression of co-stimulatory/inhibitory (CD86/CD274) markers were analyzed. The relationship between CD274+ pDCs and the Injury Severity Score (ISS) was also evaluated. Additionally, in vitro experiments were conducted using proinflammatory cytokine stimulation and blocking antibodies to assess their effects on DC activation.
Results: Trauma patients showed decreased percentages and absolute numbers of pDCs, while cDC levels remained unchanged. Cytokine production was impaired, with reduced IFN-α and TNF-α from pDCs and IL-12 from cDCs. CD86+ and CD274+ expression were increased in pDCs but decreased in cDCs, with CD274+ pDCs positively correlating with ISS scores. In vitro studies revealed that proinflammatory cytokines enhanced activation markers, peaking at 72 hours; this observation was reversed by blocking antibodies.
Conclusion: This study demonstrates that trauma induces both numerical and functional deficiencies in circulating pDCs despite increased activation marker expression. The correlation between CD274+ pDCs and trauma severity, along with the temporal dynamics of cytokine-induced activation, suggests a complex role for pDCs in post-traumatic immune responses and provides new insights for developing targeted therapies for trauma-related immune complications.
DOI: 10.5517/cctq2zk
title: CCDC 766009: Experimental Crystal Structure Determination

description: Related Article: V.I.Tsaryuk, K.P.Zhuravlev, A.V.Vologzhanina, V.A.Kudryashova, V.F.Zolin|2010|J.Photochem.Photobiol.A:Chem.|211|7|doi:10.1016/j.jphotochem.2010.01.012
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cctq30m
title: CCDC 766010: Experimental Crystal Structure Determination

description: Related Article: V.I.Tsaryuk, K.P.Zhuravlev, A.V.Vologzhanina, V.A.Kudryashova, V.F.Zolin|2010|J.Photochem.Photobiol.A:Chem.|211|7|doi:10.1016/j.jphotochem.2010.01.012
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30404902.v1
title: Supplementary Material for: Circulating Plasmacytoid Dendritic Cells are Numerically and Functionally Deficient in Trauma Patients

description: Introduction: Dendritic cells (DCs) are crucial in immune responses but their roles in trauma patients remain poorly understood. This study aimed to investigate the frequencies and functions of plasmacytoid DCs (pDCs) and conventional DCs (cDCs) in trauma patients.
Methods: This study included 25 trauma patients and 40 healthy controls. Using flow cytometry, the frequencies, cytokine production (IFN-α, TNF-α, IL-12), and expression of co-stimulatory/inhibitory (CD86/CD274) markers were analyzed. The relationship between CD274+ pDCs and the Injury Severity Score (ISS) was also evaluated. Additionally, in vitro experiments were conducted using proinflammatory cytokine stimulation and blocking antibodies to assess their effects on DC activation.
Results: Trauma patients showed decreased percentages and absolute numbers of pDCs, while cDC levels remained unchanged. Cytokine production was impaired, with reduced IFN-α and TNF-α from pDCs and IL-12 from cDCs. CD86+ and CD274+ expression were increased in pDCs but decreased in cDCs, with CD274+ pDCs positively correlating with ISS scores. In vitro studies revealed that proinflammatory cytokines enhanced activation markers, peaking at 72 hours; this observation was reversed by blocking antibodies.
Conclusion: This study demonstrates that trauma induces both numerical and functional deficiencies in circulating pDCs despite increased activation marker expression. The correlation between CD274+ pDCs and trauma severity, along with the temporal dynamics of cytokine-induced activation, suggests a complex role for pDCs in post-traumatic immune responses and provides new insights for developing targeted therapies for trauma-related immune complications.
DOI: 10.5517/ccs9txs
title: CCDC 724436: Experimental Crystal Structure Determination

description: Related Article: T.Yamaguchi, K.Nanba, T.Ozeki, S.Irie, M.Irie|2010|J.Photochem.Photobiol.A:Chem.|213|141|doi:10.1016/j.jphotochem.2010.05.013
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccs9tyt
title: CCDC 724437: Experimental Crystal Structure Determination

description: Related Article: T.Yamaguchi, K.Nanba, T.Ozeki, S.Irie, M.Irie|2010|J.Photochem.Photobiol.A:Chem.|213|141|doi:10.1016/j.jphotochem.2010.05.013
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.zff66h
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Sphenodontia, Crocodylia, Squamata, Testudines)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((52.5 -45,60 -45,60 -37.5,52.5 -37.5,52.5 -45))"
 ]
}

 The dataset includes 26 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0046287-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccsqffb
title: CCDC 736542: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccsqfgc
title: CCDC 736543: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30404905
title: Supplementary Material for: Impact of Abemaciclib-induced Serum Creatinine Elevation on Dose Adjustment of Concomitant Medications

description: Introduction: Abemaciclib (ABE) is a selective cyclin-dependent kinase 4/6 inhibitor widely used in breast cancer treatment. ABE inhibits renal tubular transporters such as organic cation transporter 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2-K, thereby suppressing creatinine excretion. This leads to a reversible increase in serum creatinine (Scr) without causing true renal injury. Since Scr is commonly used to assess renal function and guide medication dose adjustments, this effect may influence the management of concomitant renally excreted drugs. We aimed to evaluate the impact of ABE-induced Scr changes on the dosing of concomitant renally excreted medications in real-world clinical practice.
Methods: In this retrospective observational study, we included female patients who initiated ABE at Hokkaido Cancer Center between March 1, 2018, and March 31, 2023. Renal function was classified based on the Kidney Disease: Improving Global Outcomes guidelines, using creatinine clearance (CCr) cutoff values of 60 mL/min and 30 mL/min. The primary endpoint was the proportion of patients whose renal function classification changed post-ABE initiation, based on the lowest CCr value recorded during treatment.
Results: Of 221 patients included in this study, 30.8% had grade ≥2 Scr elevation at 1 month post-ABE initiation, increasing to 56.6% after 2 years. CCr significantly decreased after ABE initiation compared with that at baseline (median [interquartile range]: 44.5 [34.7–55.7] mL/min vs. 61.6 [49.3–81.1] mL/min, P &lt; 0.01). After ABE discontinuation, CCr values returned to baseline levels. Overall, 50.2% of patients experienced a change in renal function classification after ABE initiation (P &lt; 0.01), and 22.6% required dose adjustment owing to these changes.
Conclusion: ABE administration led to Scr elevation and changes in renal function classification in approximately half of patients, impacting dose adjustment of concomitant renally-excreted medications. Therefore, appropriate management methods, including cystatin C-based renal evaluation, are necessary.
DOI: 10.5517/ccsqfhd
title: CCDC 736544: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccsqfjf
title: CCDC 736545: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30404905.v1
title: Supplementary Material for: Impact of Abemaciclib-induced Serum Creatinine Elevation on Dose Adjustment of Concomitant Medications

description: Introduction: Abemaciclib (ABE) is a selective cyclin-dependent kinase 4/6 inhibitor widely used in breast cancer treatment. ABE inhibits renal tubular transporters such as organic cation transporter 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2-K, thereby suppressing creatinine excretion. This leads to a reversible increase in serum creatinine (Scr) without causing true renal injury. Since Scr is commonly used to assess renal function and guide medication dose adjustments, this effect may influence the management of concomitant renally excreted drugs. We aimed to evaluate the impact of ABE-induced Scr changes on the dosing of concomitant renally excreted medications in real-world clinical practice.
Methods: In this retrospective observational study, we included female patients who initiated ABE at Hokkaido Cancer Center between March 1, 2018, and March 31, 2023. Renal function was classified based on the Kidney Disease: Improving Global Outcomes guidelines, using creatinine clearance (CCr) cutoff values of 60 mL/min and 30 mL/min. The primary endpoint was the proportion of patients whose renal function classification changed post-ABE initiation, based on the lowest CCr value recorded during treatment.
Results: Of 221 patients included in this study, 30.8% had grade ≥2 Scr elevation at 1 month post-ABE initiation, increasing to 56.6% after 2 years. CCr significantly decreased after ABE initiation compared with that at baseline (median [interquartile range]: 44.5 [34.7–55.7] mL/min vs. 61.6 [49.3–81.1] mL/min, P &lt; 0.01). After ABE discontinuation, CCr values returned to baseline levels. Overall, 50.2% of patients experienced a change in renal function classification after ABE initiation (P &lt; 0.01), and 22.6% required dose adjustment owing to these changes.
Conclusion: ABE administration led to Scr elevation and changes in renal function classification in approximately half of patients, impacting dose adjustment of concomitant renally-excreted medications. Therefore, appropriate management methods, including cystatin C-based renal evaluation, are necessary.
DOI: 10.5517/ccsqfkg
title: CCDC 736546: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccsqflh
title: CCDC 736547: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccsqfmj
title: CCDC 736548: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccsqfnk
title: CCDC 736549: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccsqfpl
title: CCDC 736550: Experimental Crystal Structure Determination

description: Related Article: B.Ojha, G.Das|2010|J.Photochem.Photobiol.A:Chem.|211|176|doi:10.1016/j.jphotochem.2010.01.021
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.