cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60641/3jwa-9s06
title: Adult Temperament Questionnaire (ATQ)

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The Adult Temperament Questionnaire (ATQ) is a 77-item questionnaire that measures self-reported effortful control, negative affect/neuroticism, extraversion/surgency, and orienting sensitivity. Each item is scored on a 7-point Likert-scale.
description: Within L-CID, 35 items from the Effortful control subscale (consisting of Attentional control, Activation control and Inhibitory control) and the Orienting sensitivity subscale (consisting of Neutral Perceptual Sensitivity, Affective Perceptual Sensitivity, and Associative Sensitivity) were used. When the parent indicated to have a partner, the questions were asked to the partner as well.
DOI: 10.60641/zkkh-sa52
title: fMRI - Social Delay Discounting Task (SDDT)

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The fMRI - Social Delay Discounting Task measures brain activity during the Social Delay Discounting Task that measures impulse control in a social context. In the task, the child is asked first to choose between a small amount of money now or a larger amount later. Next, the child is presented with a choice between receiving a smaller amount of money for themselves immediately or a larger amount for a friend at a later time. Similarly, the child is asked to make the same decision but for a stranger instead.
description: The SDDT was presented on a screen that participants viewed through a mirror attached to the head coil. Functional runs of the SDDT were acquired using a T1*-weighted turbo field echo (T1TFE) sequence. To account for T1 saturation effects, the first two volumes (dummy volumes) were discarded at the beginning of the scan. During the Middle Childhood Cohort waves, the SDDT consisted of 3 runs in total, with the number of volumes varying depending on the individual participant. The volumes covered the entire brain with a field of view (FOV) measuring 220 mm in the anterior-posterior (ap) direction, 220 mm in the right-left (rl) direction, and 111.65 mm in the foot-head (fh) direction. The imaging protocol used a repetition time (TR) of 2.2 seconds, an echo time (TE) of 30 ms, and a flip angle (FA) of 80°. The data was acquired sequentially in 37 slices with a voxel size of 2.75 mm x 2.75 mm x 2.75 mm.
DOI: 10.60641/yc67-v540
title: Pandemic Questionnaire

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The Pandemic Questionnaire is a self-developed questionnaire that aims to measure Covid-19-symptoms (e.g., fever, coughing, runny nose), Covid-19-related behaviors (e.g., meeting friends on crowded places, staying home as much as possible), and pandemic-related feelings (e.g., feeling inclined to help others, feelings of stress). The child-report version consists of 22 items, and parent-report version of only 4 items about symptoms and being at-risk.
DOI: 10.60641/dd17-sm88
title: Perceived Stress Scale (PSS)

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The Perceived Stress Scale (PSS) consists of 14 items and measures feelings of stress and anxiety in the past two weeks.
description: In the Covid-19 waves of L-CID, only 10 items were used.
DOI: 10.60641/js86-j107
title: Social Media Questionnaire (SMQ)

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The Social Media Questionnaire measures social media use, rules and attitudes about social media. The parent-report version consists of 42 items, with A, B, C, and D subscales. The child-report version consists of 35 items, with A, B, and C subscales.
DOI: 10.60641/xn4x-2q98
title: Saliva sample - Testosterone

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: Saliva was collected using a cotton swab or a collection device, such as a tube or container (passive drool).
description: In L-CID, the saliva sample of passive drool was used to measure testosterone. Over the course of the two weekdays (first two days of data collection), parents collected saliva samples from their children at three time-points (after awakening, between 16:00 and 18:00 and 30 minutes after dinner). The saliva was collected by requiring the children to spit into a small tube (passive drooling). Parents were asked to store the saliva in the freezer. Once collected, saliva samples were stored at −20° Celsius at the university.
DOI: 10.60641/58hw-gv84
title: fMRI - Prosocial Cyberball Game

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The fMRI - Prosocial Cyberball Game measures brain activity during the Prosocial Cyberball Game, in which a child has the opportunity to help a socially-excluded child in a ball throwing game.
description: Functional runs of the PCG were acquired using a T2*-weighted echo-planar imaging (EPI) technique. The first two volumes (dummy volumes) were discarded to allow for equilibration of T1 saturation effects. In total, there were 2 PCG runs conducted. The number of volumes acquired varied based on each participant's reaction time, with a maximum of 175 volumes. On average, 136 volumes (equivalent to 4.99 minutes) were acquired for each PCG run. The parameters used remained constant throughout the waves. The acquired volumes covered the entire brain, utilizing the following imaging parameters: a field of view (FOV) of 220 mm in the anterior-posterior (ap) direction, 220 mm in the right-left (rl) direction, and 111.65 mm in the foot-head (fh) direction. The imaging protocol included a repetition time (TR) of 2.2 seconds, an echo time (TE) of 30 ms, and a flip angle (FA) of 80°. The data was acquired sequentially in 37 slices, with a voxel size of 2.75 mm x 2.75 mm x 2.75 mm.
DOI: 10.60641/aq2y-s837
title: Parenting Practices Questionnaire - Warmth/Involvement (PPQ-WI)

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The Parenting Practices Questionnaire (PPQ) consists of 62 items that assess parenting style by asking the child about their parents' behavior.
description: Within L-CID, 11 items from the warmth/involvement subscale were used.
DOI: 10.60641/2psv-r012
title: MyChild - Internalized Conduct

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The MyChild questionnaire aims to measure conscience, moral development, and internalized compliance. It consists of 100 items over 10 different subscales that are rated on an 8-point Likert scale.
description: Within L-CID, 3 subscales were measured: Empathy, Guilt and Internalized Conduct. The MyChild - Internalized Conduct subscale consists of 15 items that assess a child's tendencies for internalized conduct according to their parent(s).
DOI: 10.17179/excli2024-7359_supplementary_data
title: Deoxybouvardin-glucoside induces apoptosis in non-small cell lung cancer cells by targeting EGFR/MET and AKT signaling pathway

description: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Its treatment is complicated due to the development of resistance to conventional chemotherapy and targeted therapy. Deoxybouvardin and related cyclic hexapeptides reportedly exhibit antitumor activities, but their mechanisms of action remain unclear. This study aimed to investigate the anticancer mechanisms of deoxybouvardin glucoside (DBG), a glucosidic form of deoxybouvardin from Rubia species, in gefitinib (GEF)-sensitive and -resistant NSCLC HCC827 cells. The effects of DBG treatment on cell proliferation were evaluated using a viability assay. The inhibitory effects of DBG treatment on the activities and phosphorylation of the protein kinases epidermal growth factor receptor (EGFR), MET, and AKTs were assessed using in vitro kinase assay and western blot, respectively. DBG treatment inhibited the growth of HCC827 cells in a concentration- and time-dependent manner. Results of in vitro kinase assay and western blotting showed that DBG treatment significantly inhibited the activities and phosphorylation of the protein kinases EGFR, MET, and AKT. Prediction using molecular docking showed that DBG is located in the ATP-binding pockets of these kinases, supporting the kinase inhibition by DBG treatment. Moreover, DBG treatment induced reactive oxygen species (ROS) generation and cell cycle arrest in the cells. The induction of apoptosis by DBG through caspase activation was confirmed by Z-VAD-FMK treatment. In summary, DBG treatment inhibited the growth of GEF-sensitive and -resistant NSCLC cells by targeting EGFR, MET, and AKTs. Moreover, it induced apoptosis by inducing ROS generation and caspase activation. These results indicate that DBG is a potential therapeutic agent for the treatment of GEF-resistant NSCLC.
description: EXCLI Journal; 23:Doc1287; ISSN 1611-2156
DOI: 10.60641/96ap-6324
title: Dutch Social Reward Questionnaire (DSRQ)

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The Dutch Social Reward Questionnaire (DSRQ) measures an individual's sensitivity to social rewards. It assesses how much people enjoy and seek social interactions, approval, and positive social feedback, providing insights into the motivational aspects of social behavior. This questionnaire consists of 20 items divided within six categories: Admiration, Negative Social Potency, Passivity, Prosocial Interactions, Sexual Reward, and Sociability.
DOI: 10.5517/ccdc.csd.cc2hgxb7
title: CCDC 2308239: Experimental Crystal Structure Determination

description: Related Article: Shengxiang Qin, Yaqi Zhang, Long Jiang, Man Kin Tse, Albert S. C. Chan, Liqin Qiu|2024|Green Chemistry|26|10299|doi:10.1039/D4GC03356F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60641/ysnr-0d42
title: School Questionnaire

description: The Leiden Consortium on Individual Development (L-CID) study was founded by Marinus van IJzendoorn, Eveline Crone, Marian Bakermans-Kranenburg and Rutger Engels in 2013. It was developed as one of four work packages of the overarching Consortium on Individual Development (CID). The L-CID study is a large-scale longitudinal intervention study in which 500 families with same-sex twins are followed over a six year period. L-CID has a cohort-sequential design with two cohorts: an early childhood cohort (ECC), aged 3-4 at wave 1, and a middle childhood cohort (MCC), aged 7-8 at wave 1. Annual assessments consist of alternating lab- or home visits during which behavioral and neurobiological data are collected. The collected data allow, among others, for testing which child characteristics shape the effect of (manipulated) environmental factors. The aim of L-CID is twofold: 1. To investigate the development of social competence and behavioral control in children between 3 and 14 years old; 2. To dissect the reason why not all children are equally responsive to variations in the social environment.
description: The self-developed School Questionnaire consists of 8 items about school-going of the children: (1) Do child 1 and child 2 go to school together?, (2) Are child 1 and child 2 in the same class?, (3) Was this choice made by you or by the school of child 1 and child 2?, (4) Did child 1 and child 2 go to the same school in previous years?, (5) Were child 1 and child 2 in the same class in previous years?, (6) What kind of school do child 1 and child 2 go to?, (7) In which group/class are child 1 and child 2? and (8) What level of education do child 1 and child 2 have?
DOI: 10.5517/ccdc.csd.cc2j14pf
title: CCDC 2324804: Experimental Crystal Structure Determination

description: Related Article: Raju Ram Puniya, Priyanka Takhar, Monika Chhapoliya, Rinki Deka, Dhruba Jyoti Kalita, Devendra Singh|2024|Mat.Advs.|5|7817|doi:10.1039/D4MA00634H
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.