cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29880857.v2
title: STOML2 knockdown inhibits inflammation and airway remodeling of PDGF-BB-induced airway smooth-muscle cells by the MAPK pathway

description: Asthma is a chronic inflammatory airway disease characterized by airway inflammation and remodeling. Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs), induced by platelet-derived growth factor BB (PDGF-BB), are associated with the occurrence and progression of asthma. In this study, we aim to investigate the expression and molecular mechanisms of stomatin-like protein-2 (STOML2) in airway remodeling in asthma. PDGF-BB-stimulated HASMCs were used as the asthma cell model. STOML2 expression levels in the serum of patients with asthma and healthy controls were measured using qRT-PCR. Additionally, qRT-PCR and western blotting were used to measure STOML2, E-cadherin, and N-cadherin expression in HASMCs. Extracellular matrix components were detected by western blot assay. The viability and migration of HASMCs were analyzed using MTT and Transwell assays. Tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6 contents were evaluated using the corresponding kits. The key molecules of the p38 mitogen-activated protein kinase (p38 MAPK) pathway (p38 and p38) were determined using western blotting. Increased STOML2 expression was observed in both patients with asthma and PDGF-BB-treated HASMCs. STOML2 knockdown inhibits STOML2 expression in HASMCs. PDGF-BB induced proliferation, migration, extracellular matrix deposition, inflammatory responses, and p38 MAPK pathway activation in HASMCs. However, the opposite effects were observed following STOML2 knockdown or SB-203580 treatment, respectively. Furthermore, P79350 treatment reversed the effect of STOML2 knockdown. Our results showed that silencing STOML2 inhibits inflammation and airway remodeling in PDGF-BB-stimulated HASMCs via the p38 MAPK pathway. Thus, STOML2 is a promising therapeutic target for the treatment of asthma.
DOI: 10.5517/ccdc.csd.cc1p50nj
title: CCDC 1553957: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50pk
title: CCDC 1553958: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.29545721.v1
title: Artificial Intelligence Performance in Pediatric Asthma

description: Asthma is the most common chronic disease of childhood, characterized by symptoms such as wheezing, shortness of breath, and coughing. With the advancement of technology, artificial intelligence applications are increasingly being used in various fields, among which ChatGPT is one of the most widely utilized. The aim of this study is to evaluate the reliability, quality, and readability of the answers provided by the ChatGPT-4o application to questions related to pediatric asthma. The ChatGPT-4o application was used to record answers to 25 of the most frequently asked questions about asthma in children. To determine the reliability of the answers, we used the Global Quality Scale and modified DISCERN tool. We tested readability using seven indices: Automated Readability Index, Flesch Reading Ease Score, Flesch-Kincaid Grade Level, Gunning Fog Readability Index, Simple Measure of Gobbledygook, Coleman-Liau Readability Index, and Linsear Write Formula. The answers provided by the ChatGPT-4o application to questions about childhood asthma were found to have good reliability (88% by the first evaluator and 84% by the second evaluator) and high quality (88% by both evaluators). The application scored 10.77 ± 1.58 on the Flesch-Kincaid Grade Level scale, and in conjunction with the other indices, the results indicated that the answers required a high level of reading proficiency. Artificial intelligence can be a reliable tool for parents in providing information about pediatric asthma. However, these findings suggest that readability issues may hinder the clinical application of artificial intelligence-generated content in asthma diagnosis and treatment.
DOI: 10.5517/ccdc.csd.cc1p50ql
title: CCDC 1553959: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50rm
title: CCDC 1553960: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50sn
title: CCDC 1553961: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50tp
title: CCDC 1553962: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.aa6ng4
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "StateProvince is COnnecticut"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055076-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc1p50vq
title: CCDC 1553963: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50wr
title: CCDC 1553964: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50xs
title: CCDC 1553965: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p50yt
title: CCDC 1553966: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.27626269
title: Contribution of an academic writing intervention on the micro-macrostructure skills of students with intellectual disability

description: Academic writing is a complex task involving microstructure (linguistic-level) and macrostructure (coherence structure) indices. Our goal was to examine the contribution of an academic writing intervention programme among students with intellectual disability at the microstructure and macrostructure levels while characterising the learning curves. Six students with mild intellectual disability studying for a BA (MCA = 30.43, MIQ = 69.17) participated in a spiral intervention programme of 32 lessons focusing on improving paragraph complexity and text structure measured at five time-points. Microstructure improvement in number of words, sentences, paragraphs, words per paragraph, lexical density, adjectives along with macrostructure improvement in text-paragraph structure, global-local linkage were found. A rapid increase in macrostructure indices was observed between the first and second testing points, after which a ceiling effect was reached. Concurrently, microstructure indices demonstrated a slower, more gradual learning curve throughout the intervention period. The discussion will focus on the improvement patterns in microstructure–macrostructure indices and the various learning curves observed. It explores the implications of these findings for cognitive modifiability in adults with intellectual disability and the potential of tailored academic writing interventions in post-secondary education programmes. A long-term, spiral intervention programme was effective at improving academic writing skills that require high cognitive involvement among individuals with intellectual disabilities in microstructure and macrostructure indices.Different types of linear learning curves showed a rapid increase in macrostructure indices, alongside a mixed rate of improvement in microstructure indices.The participants' thinking skills improved from focused thinking to transcendental thinking following the Structural Cognitive Modifiability (Feuerstein, 2003).The results can be explained via the Compensatory Trajectory theory (Lifshitz, 2020; 2015) which claims that chronological age plays an important role in determining the cognitive level and ability in adults with intellectual disabilities. A long-term, spiral intervention programme was effective at improving academic writing skills that require high cognitive involvement among individuals with intellectual disabilities in microstructure and macrostructure indices. Different types of linear learning curves showed a rapid increase in macrostructure indices, alongside a mixed rate of improvement in microstructure indices. The participants' thinking skills improved from focused thinking to transcendental thinking following the Structural Cognitive Modifiability (Feuerstein, 2003). The results can be explained via the Compensatory Trajectory theory (Lifshitz, 2020; 2015) which claims that chronological age plays an important role in determining the cognitive level and ability in adults with intellectual disabilities.
DOI: 10.6084/m9.figshare.27626269.v1
title: Contribution of an academic writing intervention on the micro-macrostructure skills of students with intellectual disability

description: Academic writing is a complex task involving microstructure (linguistic-level) and macrostructure (coherence structure) indices. Our goal was to examine the contribution of an academic writing intervention programme among students with intellectual disability at the microstructure and macrostructure levels while characterising the learning curves. Six students with mild intellectual disability studying for a BA (MCA = 30.43, MIQ = 69.17) participated in a spiral intervention programme of 32 lessons focusing on improving paragraph complexity and text structure measured at five time-points. Microstructure improvement in number of words, sentences, paragraphs, words per paragraph, lexical density, adjectives along with macrostructure improvement in text-paragraph structure, global-local linkage were found. A rapid increase in macrostructure indices was observed between the first and second testing points, after which a ceiling effect was reached. Concurrently, microstructure indices demonstrated a slower, more gradual learning curve throughout the intervention period. The discussion will focus on the improvement patterns in microstructure–macrostructure indices and the various learning curves observed. It explores the implications of these findings for cognitive modifiability in adults with intellectual disability and the potential of tailored academic writing interventions in post-secondary education programmes. A long-term, spiral intervention programme was effective at improving academic writing skills that require high cognitive involvement among individuals with intellectual disabilities in microstructure and macrostructure indices.Different types of linear learning curves showed a rapid increase in macrostructure indices, alongside a mixed rate of improvement in microstructure indices.The participants' thinking skills improved from focused thinking to transcendental thinking following the Structural Cognitive Modifiability (Feuerstein, 2003).The results can be explained via the Compensatory Trajectory theory (Lifshitz, 2020; 2015) which claims that chronological age plays an important role in determining the cognitive level and ability in adults with intellectual disabilities. A long-term, spiral intervention programme was effective at improving academic writing skills that require high cognitive involvement among individuals with intellectual disabilities in microstructure and macrostructure indices. Different types of linear learning curves showed a rapid increase in macrostructure indices, alongside a mixed rate of improvement in microstructure indices. The participants' thinking skills improved from focused thinking to transcendental thinking following the Structural Cognitive Modifiability (Feuerstein, 2003). The results can be explained via the Compensatory Trajectory theory (Lifshitz, 2020; 2015) which claims that chronological age plays an important role in determining the cognitive level and ability in adults with intellectual disabilities.
DOI: 10.5517/ccdc.csd.cc1p50zv
title: CCDC 1553967: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p510x
title: CCDC 1553968: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p511y
title: CCDC 1553969: Experimental Crystal Structure Determination

description: Related Article: Brennan S. Billow, Tanner J. McDaniel, Aaron L. Odom|2017|Nature Chemistry|9|837|doi:10.1038/nchem.2843
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p512z
title: CCDC 1553970: Experimental Crystal Structure Determination

description: Related Article: Corey P. Burns, Branford O. Wilkins, Courtney M. Dickie, Trevor P. Latendresse, Larry Vernier, Kuduva R. Vignesh, Nattamai S. Bhuvanesh, Michael Nippe|2017|Chem.Commun.|53|8419|doi:10.1039/C7CC02457F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1kk8ky
title: CCDC 1446570: Experimental Crystal Structure Determination

description: Related Article: Elvis Robles-Marín, Alexander Mondragón, Paulina R. Martínez-Alanis, Gabriel Aullón, Marcos Flores-Alamo, Ivan Castillo|2018|Dalton Trans.|47|10932|doi:10.1039/C8DT01562G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5174
title: CCDC 1553975: Experimental Crystal Structure Determination

description: Related Article: Leo A. Joyce, Christopher C. Nawrat, Edward C. Sherer, Mirlinda Biba, Andrew Brunskill, Gary E. Martin, Ryan D. Cohen, Ian W. Davies|2018|Chemical Science|9|415|doi:10.1039/C7SC04249C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p57vy
title: CCDC 1554180: Experimental Crystal Structure Determination

description: Related Article: Elvis Robles-Marín, Alexander Mondragón, Paulina R. Martínez-Alanis, Gabriel Aullón, Marcos Flores-Alamo, Ivan Castillo|2018|Dalton Trans.|47|10932|doi:10.1039/C8DT01562G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p57wz
title: CCDC 1554181: Experimental Crystal Structure Determination

description: Related Article: Elvis Robles-Marín, Alexander Mondragón, Paulina R. Martínez-Alanis, Gabriel Aullón, Marcos Flores-Alamo, Ivan Castillo|2018|Dalton Trans.|47|10932|doi:10.1039/C8DT01562G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p51kg
title: CCDC 1553985: Experimental Crystal Structure Determination

description: Related Article: Ryan R. Maar,  Amir Rabiee Kenaree,  Ruizhong Zhang,  Yichen Tao,  Benjamin D. Katzman,  Viktor N. Staroverov,  Zhifeng Ding,  and Joe B. Gilroy|2017|Inorg.Chem.|56|12436|doi:10.1021/acs.inorgchem.7b01907
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p51lh
title: CCDC 1553986: Experimental Crystal Structure Determination

description: Related Article: Manuel R. Rodríguez, Álvaro Beltrán, Ángel Mudarra, Eleuterio Álvarez, Feliu Maseras, M. Mar Díaz-Requejo, Pedro J. Pérez|2017|Angew.Chem.,Int.Ed.|56|12842|doi:10.1002/anie.201705664
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p51mj
title: CCDC 1553987: Experimental Crystal Structure Determination

description: Related Article: Manuel R. Rodríguez, Álvaro Beltrán, Ángel Mudarra, Eleuterio Álvarez, Feliu Maseras, M. Mar Díaz-Requejo, Pedro J. Pérez|2017|Angew.Chem.,Int.Ed.|56|12842|doi:10.1002/anie.201705664
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.