cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30676016
title: Supplementary Material for: Aflibercept 2 mg for Neovascular Age-Related Macular Degeneration: XTEND at 3 Years

description: Introduction: Long-term, global, data evaluating intravitreal aflibercept (IVT-AFL) 2 mg for treatment of neovascular age-related macular degeneration (nAMD) in real-world practice are needed. This study investigated the long-term, real-world effectiveness and safety of IVT-AFL 2 mg in patients with nAMD.

Methods: XTEND was a multicenter, observational, prospective study. Enrollment was conducted between May 2019 and May 2020; patient follow-up period was 36 months. Treatment-naïve patients were treated with IVT-AFL 2 mg (fixed dosing or treat-and-extend [T&E]) according to the local label; for the T&E regimen, treatment intervals could be extended according to the national label (either European Medicines Agency [EMA]-aligned or non-EMA-aligned).

Results: Overall, 1483 patients across 17 countries were treated with IVT-AFL 2 mg; mean ± standard deviation (SD) age was 78.8 ± 8.5 years; 60.4% were female. Overall, 62.6% of patients completed the 36-month follow-up visit. The mean (95% confidence interval [CI]) changes in best-corrected visual acuity from baseline were +4.6 (3.7, 5.4), +2.3 (1.3, 3.3), and +0.9 (−0.2, 1.9) at Months 12, 24, and 36, respectively. The mean (95% CI) changes in central subfield thickness from baseline were −106 (−114, −99) μm, −109 (−117, −102) μm, and −110 (−118, −103) μm at Months 12, 24, and 36, respectively. The mean ± SD numbers of injections from baseline to Months 12, 24, and 36 were 7.7 ± 2.7, 11.3 ± 5.3, and 13.7 ± 7.5, respectively. No new safety concerns were identified.

Conclusion: This study demonstrates that improvements with IVT-AFL 2 mg were maintained through Month 36, suggesting that long-term durability of vision is achievable in patients with treatment-naïve nAMD in real-world practice.

Trial Registration: ClinicalTrials.gov Identifier: NCT03939767. Available at: https://www.clinicaltrials.gov/study/NCT03939767
DOI: 10.6084/m9.figshare.30676016.v1
title: Supplementary Material for: Aflibercept 2 mg for Neovascular Age-Related Macular Degeneration: XTEND at 3 Years

description: Introduction: Long-term, global, data evaluating intravitreal aflibercept (IVT-AFL) 2 mg for treatment of neovascular age-related macular degeneration (nAMD) in real-world practice are needed. This study investigated the long-term, real-world effectiveness and safety of IVT-AFL 2 mg in patients with nAMD.

Methods: XTEND was a multicenter, observational, prospective study. Enrollment was conducted between May 2019 and May 2020; patient follow-up period was 36 months. Treatment-naïve patients were treated with IVT-AFL 2 mg (fixed dosing or treat-and-extend [T&E]) according to the local label; for the T&E regimen, treatment intervals could be extended according to the national label (either European Medicines Agency [EMA]-aligned or non-EMA-aligned).

Results: Overall, 1483 patients across 17 countries were treated with IVT-AFL 2 mg; mean ± standard deviation (SD) age was 78.8 ± 8.5 years; 60.4% were female. Overall, 62.6% of patients completed the 36-month follow-up visit. The mean (95% confidence interval [CI]) changes in best-corrected visual acuity from baseline were +4.6 (3.7, 5.4), +2.3 (1.3, 3.3), and +0.9 (−0.2, 1.9) at Months 12, 24, and 36, respectively. The mean (95% CI) changes in central subfield thickness from baseline were −106 (−114, −99) μm, −109 (−117, −102) μm, and −110 (−118, −103) μm at Months 12, 24, and 36, respectively. The mean ± SD numbers of injections from baseline to Months 12, 24, and 36 were 7.7 ± 2.7, 11.3 ± 5.3, and 13.7 ± 7.5, respectively. No new safety concerns were identified.

Conclusion: This study demonstrates that improvements with IVT-AFL 2 mg were maintained through Month 36, suggesting that long-term durability of vision is achievable in patients with treatment-naïve nAMD in real-world practice.

Trial Registration: ClinicalTrials.gov Identifier: NCT03939767. Available at: https://www.clinicaltrials.gov/study/NCT03939767
DOI: 10.15139/s3/xbrar2
title: Data Management and Sharing Plan for: Biomaterial Scaffolds for Ex Vivo and In Situ CAR-T Cell Production

description: The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data.
description: Data Management and Sharing Plan
DOI: 10.6084/m9.figshare.30676019
title: Supplementary Material for: Assessing Tumour Budding in Lung Squamous Cell Carcinoma: A Comparative Analysis of Digital Whole Slide Imaging and Light Microscopy

description: Introduction
Tumour budding (TB) is an emerging prognostic marker in solid cancers and has recently been endorsed by the IASLC as a component of grading in lung squamous cell carcinoma (LUSC). With the growing adoption of digital pathology, the reproducibility of TB assessment on whole-slide images (WSI) warrants evaluation.
Methods
We assessed the utility of WSI for TB evaluation in a retrospective cohort of 204 resected LUSC cases. Peritumoral budding (PTB) and intratumoural budding (ITB) were independently scored by two pathologists, applying the International Tumour Budding Consensus Conference (ITBCC) criteria established for colorectal cancer and endorsed by the IASLC for use in LUSC. 816 TB hotspot regions were analyzed.
Results
Substantial intraobserver reliability was observed, with strong correlations between absolute bud counts in WSI and CLM (R = 0.845, P &lt; 0.001; R = 0.880, P &lt; 0.001). Interobserver agreement was moderate for both PTB and ITB across platforms [Cohen’s κ: CLM 0.582 (PTB), 0.570 (ITB); WSI 0.593 (PTB), 0.423 (ITB)]. Discordance mainly occurred in lower TB categories due to differences in hotspot selection and morphological mimics. When applying the recently proposed IASLC two-tier cutoff (0–9 buds vs ≥10 buds), interobserver agreement for PTB improved modestly (κ = 0.49 for CLM; κ = 0.53 for WSI), with overall agreement exceeding 93%.
Conclusion
These findings support the feasibility and reproducibility of TB assessment using WSI and highlight its potential for standardizing LUSC TB evaluation in digital pathology workflows. WSI also demonstrated practical advantages, including easier field selection and annotation.
DOI: 10.6084/m9.figshare.30676019.v1
title: Supplementary Material for: Assessing Tumour Budding in Lung Squamous Cell Carcinoma: A Comparative Analysis of Digital Whole Slide Imaging and Light Microscopy

description: Introduction
Tumour budding (TB) is an emerging prognostic marker in solid cancers and has recently been endorsed by the IASLC as a component of grading in lung squamous cell carcinoma (LUSC). With the growing adoption of digital pathology, the reproducibility of TB assessment on whole-slide images (WSI) warrants evaluation.
Methods
We assessed the utility of WSI for TB evaluation in a retrospective cohort of 204 resected LUSC cases. Peritumoral budding (PTB) and intratumoural budding (ITB) were independently scored by two pathologists, applying the International Tumour Budding Consensus Conference (ITBCC) criteria established for colorectal cancer and endorsed by the IASLC for use in LUSC. 816 TB hotspot regions were analyzed.
Results
Substantial intraobserver reliability was observed, with strong correlations between absolute bud counts in WSI and CLM (R = 0.845, P &lt; 0.001; R = 0.880, P &lt; 0.001). Interobserver agreement was moderate for both PTB and ITB across platforms [Cohen’s κ: CLM 0.582 (PTB), 0.570 (ITB); WSI 0.593 (PTB), 0.423 (ITB)]. Discordance mainly occurred in lower TB categories due to differences in hotspot selection and morphological mimics. When applying the recently proposed IASLC two-tier cutoff (0–9 buds vs ≥10 buds), interobserver agreement for PTB improved modestly (κ = 0.49 for CLM; κ = 0.53 for WSI), with overall agreement exceeding 93%.
Conclusion
These findings support the feasibility and reproducibility of TB assessment using WSI and highlight its potential for standardizing LUSC TB evaluation in digital pathology workflows. WSI also demonstrated practical advantages, including easier field selection and annotation.
DOI: 10.5281/zenodo.16561910
title: Dataset for publication: "Three decades of GNSS-derived geocenter motion: disentangling geophysical signal from systematic errors"

description: This dataset contains two combined geocenter time series solutions (V3M and V7D) that serve as supplementary data to the article "Three decades of GNSS-derived geocenter motion: disentangling geophysical signal from systematic errors" currently under review in Advances in Space Research. The solutions are derived from a comprehensive analysis of ten International GNSS Service (IGS) Analysis Centers spanning three decades (1994-2025). 

Dataset Components:



V3M Solution: Combined geocenter series using 3-month sliding window for variance component estimation

V7D Solution: Combined geocenter series using 7-day sliding window for variance component estimation


Data Structure:



GPS Week: GPS week number

Day of GPS Week: Day within the GPS week (0-6)

MJD: Modified Julian Date

ISO Date: Date in ISO 8601 format (YYYY-MM-DDTHH:MM:SSZ)

X, Y, Z: Geocenter coordinates in millimeters

XE, YE, ZE: Formal errors for X, Y, Z components in millimeters


Methodology: The combined solutions are produced using Förstner's variance component estimation method, which optimally weights contributions from individual IGS Analysis Centers (COD, ESA, GFZ, GRG, JPL, MIT, NGS, TUG, ULR, WHU). 

Key Features:



Spans three processing periods: IGS Repro3, IGS Repro3 extension, and operational IGS20 products

Includes GPS, GLONASS, and Galileo constellation data

Demonstrates strong agreement with independent techniques (SLR, LEO) at seasonal timescales (correlations >0.8)

Provides parameter-level combination alternative to normal equation-based approaches


Coordinate System: Solutions referenced to IGSR3 TRF (1994-2022) and IGS20 TRF (2022-2025)

Units: Coordinates and uncertainties in millimeters (mm)

Temporal Resolution: Daily estimates with different combination window lengths

This dataset supports research in geodesy, geophysics, Earth system science, and reference frame applications, particularly for studies requiring high-quality geocenter motion estimates with reduced systematic errors.

Note: This dataset accompanies a manuscript currently under peer review and provides the combined geocenter solutions analyzed in the research paper.
DOI: 10.5281/zenodo.16561909
title: Dataset for publication: "Three decades of GNSS-derived geocenter motion: disentangling geophysical signal from systematic errors"

description: This dataset contains two combined geocenter time series solutions (V3M and V7D) that serve as supplementary data to the article "Three decades of GNSS-derived geocenter motion: disentangling geophysical signal from systematic errors" currently under review in Advances in Space Research. The solutions are derived from a comprehensive analysis of ten International GNSS Service (IGS) Analysis Centers spanning three decades (1994-2025). 

Dataset Components:



V3M Solution: Combined geocenter series using 3-month sliding window for variance component estimation

V7D Solution: Combined geocenter series using 7-day sliding window for variance component estimation


Data Structure:



GPS Week: GPS week number

Day of GPS Week: Day within the GPS week (0-6)

MJD: Modified Julian Date

ISO Date: Date in ISO 8601 format (YYYY-MM-DDTHH:MM:SSZ)

X, Y, Z: Geocenter coordinates in millimeters

XE, YE, ZE: Formal errors for X, Y, Z components in millimeters


Methodology: The combined solutions are produced using Förstner's variance component estimation method, which optimally weights contributions from individual IGS Analysis Centers (COD, ESA, GFZ, GRG, JPL, MIT, NGS, TUG, ULR, WHU). 

Key Features:



Spans three processing periods: IGS Repro3, IGS Repro3 extension, and operational IGS20 products

Includes GPS, GLONASS, and Galileo constellation data

Demonstrates strong agreement with independent techniques (SLR, LEO) at seasonal timescales (correlations >0.8)

Provides parameter-level combination alternative to normal equation-based approaches


Coordinate System: Solutions referenced to IGSR3 TRF (1994-2022) and IGS20 TRF (2022-2025)

Units: Coordinates and uncertainties in millimeters (mm)

Temporal Resolution: Daily estimates with different combination window lengths

This dataset supports research in geodesy, geophysics, Earth system science, and reference frame applications, particularly for studies requiring high-quality geocenter motion estimates with reduced systematic errors.

Note: This dataset accompanies a manuscript currently under peer review and provides the combined geocenter solutions analyzed in the research paper.
DOI: 10.5281/zenodo.17671394
title: Raw dataset for 'Synovial inflammatory profiles in horses with and without systemic B. burgdorferi infection'

description: Excel spreadsheet with anonymized raw numerical values. One set of numerical Lyme Multiplex values (i.e., OSP A, C, and F) are available per horse; this assay was only performed once per horse. Numerical cytokine and chemokine multiplex results are included per sample (as 1-3 samples were collected per horse). The cytokine and chemokine assays were performed in duplicate per sample. Abbreviations: ND=not detected (i.e., below limit of detection); NR=not ran (i.e., insufficient sample volume).
DOI: 10.5281/zenodo.17671395
title: Raw dataset for 'Synovial inflammatory profiles in horses with and without systemic B. burgdorferi infection'

description: Excel spreadsheet with anonymized raw numerical values. One set of numerical Lyme Multiplex values (i.e., OSP A, C, and F) are available per horse; this assay was only performed once per horse. Numerical cytokine and chemokine multiplex results are included per sample (as 1-3 samples were collected per horse). The cytokine and chemokine assays were performed in duplicate per sample. Abbreviations: ND=not detected (i.e., below limit of detection); NR=not ran (i.e., insufficient sample volume).
DOI: 10.15468/dl.fg3xg2
title: Occurrence Download

description: A dataset containing 19625 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Country is United States of America",
 "Geometry POLYGON((-151.25677 12.18282,2.84907 12.18282,2.84907 73.79683,-151.25677 73.79683,-151.25677 12.18282))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Carduus nutans"
 ]
}

 The dataset includes 19625 records from 132 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002346-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15139/s3/kwfdde
title: Data Management and Sharing Plan for: Learning curve evaluation supporting changes and improvements on a new developed EPA-based curriculum in Dentistry

description: The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data.
description: Data Management and Sharing Plan
DOI: 10.15468/dl.fkg7dr
title: Occurrence Download

description: A dataset containing 19376 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "TaxonKey is Gunnera tinctoria"
 ]
}

 The dataset includes 19376 records from 86 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002347-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y5pg56
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "ScientificName" : [
 "is Aningeria altissima"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002349-251120083545085/datasets/export for details.
DOI: 10.5281/zenodo.17671648
title: Field Running Incurs Higher Physiological Cost of Energy than Treadmill Running Despite Matched Speeds: Evidence from Endurance Athletes
DOI: 10.5281/zenodo.17671647
title: Field Running Incurs Higher Physiological Cost of Energy than Treadmill Running Despite Matched Speeds: Evidence from Endurance Athletes
DOI: 10.5281/zenodo.17153519
title: Mechanical properties of PBF-LB NiTi under quasi-static and cyclic compressive loading at low speed

description: The dataset contains data from mechanical testing of NiTi cylinders under quasi-static and cyclic loading at low speed.
DOI: 10.5281/zenodo.17153518
title: Mechanical properties of PBF-LB NiTi under quasi-static and cyclic compressive loading at low speed

description: The dataset contains data from mechanical testing of NiTi cylinders under quasi-static and cyclic loading at low speed.
DOI: 10.5281/zenodo.14500574
title: Dataset for publication: "Advancing Multi-GNSS Orbit Combination in the Variance Component Estimation Framework"

description: This dataset provides supplementary material for the scientific paper:Zajdel, R., Mansur, G., Sakic, P. et al. Advancing multi-GNSS orbit combination in the variance component estimation framework. J Geod 99, 90 (2025). https://doi.org/10.1007/s00190-025-02005-w

It includes solutions, configuration files, and associated data necessary for replication and further research. All detailed metadata, solutions, and content descriptions are included in the accompanying JSON file.

Access Conditions: Open AccessLicense: CC-BY-4.0Usage Notes: Please cite the accompanying paper when using this dataset.

For more information, refer to the JSON file provided with the dataset.
DOI: 10.5281/zenodo.14500573
title: Dataset for publication: "Advancing Multi-GNSS Orbit Combination in the Variance Component Estimation Framework"

description: This dataset provides supplementary material for the scientific paper:Zajdel, R., Mansur, G., Sakic, P. et al. Advancing multi-GNSS orbit combination in the variance component estimation framework. J Geod 99, 90 (2025). https://doi.org/10.1007/s00190-025-02005-w

It includes solutions, configuration files, and associated data necessary for replication and further research. All detailed metadata, solutions, and content descriptions are included in the accompanying JSON file.

Access Conditions: Open AccessLicense: CC-BY-4.0Usage Notes: Please cite the accompanying paper when using this dataset.

For more information, refer to the JSON file provided with the dataset.
DOI: 10.5281/zenodo.17672737
title: Divergent temporal responses of grassland plant and soil microbial stability to multiple global changes
DOI: 10.5281/zenodo.17320794
title: Divergent temporal responses of grassland plant and soil microbial stability to multiple global changes
DOI: 10.15468/dl.3rgbar
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Kazakhstan",
 "GadmGid is KAZ.9_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Fragaria viridis"
 ]
}

 The dataset includes 92 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002350-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4ntxam
title: Occurrence Download

description: A dataset containing 603 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aningeria altissima"
 ]
}

 The dataset includes 603 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002351-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hx2bcf
title: Occurrence Download

description: A dataset containing 72 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aningeria robusta"
 ]
}

 The dataset includes 72 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002353-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.upb7n4
title: Occurrence Download

description: A dataset containing 428960 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is NEON ticks sampled using drag cloths and tick pathogen status"
 ]
}

 The dataset includes 428960 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002348-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rzf3gc
title: Occurrence Download

description: A dataset containing 56 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Kazakhstan",
 "GadmGid is KAZ.9_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Prunus padus"
 ]
}

 The dataset includes 56 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002354-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14043672
title: IBIF: Intactness-based biodiversity impact factors

description: The intactness-based biodiversity impact factors (IBIF) dataset contains a set of consistent country-level biodiversity impact factors (BIFs) that can be used to attribute losses in local terrestrial biodiversity intactness to emissions and extractions associated with production and consumption. The BIFs were obtained with the global biodiversity model GLOBIO, which quantifies local biodiversity intactness based on the mean species abundance (MSA) indicator. IBIF (v2) contains BIFs for five environmental pressures (CO2 emissions, NH3 emissions, NOx emissions, land use (five categories) and roads) for 234 countries. For more information on how the factors were established, please see the accompanying journal article, available at:

 https://doi.org/10.1038/s41597-025-05946-1
DOI: 10.5281/zenodo.16234138
title: IBIF: Intactness-based biodiversity impact factors

description: The intactness-based biodiversity impact factors (IBIF) dataset contains a set of consistent country-level biodiversity impact factors (BIFs) that can be used to attribute losses in local terrestrial biodiversity intactness to emissions and extractions associated with production and consumption. The BIFs were obtained with the global biodiversity model GLOBIO, which quantifies local biodiversity intactness based on the mean species abundance (MSA) indicator. IBIF (v2) contains BIFs for five environmental pressures (CO2 emissions, NH3 emissions, NOx emissions, land use (five categories) and roads) for 234 countries. For more information on how the factors were established, please see the accompanying journal article, available at:

 https://doi.org/10.1038/s41597-025-05946-1
DOI: 10.15468/dl.yj437c
title: Occurrence Download

description: A dataset containing 19501 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rachycentron canadum",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 19501 records from 185 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002355-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.