cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11267540
title: Relationships between corneal biomechanics and the structural and functional parameters of glaucoma damage

description: ABSTRACT Purpose: To investigate the relationships between (i) thickness of the retinal nerve fiber layer, optic nerve head topography, and visual field parameters and (ii) corneal biomechanical properties in normal controls and patients with ocular hypertension and primary open-angle glaucoma. Methods: This observational, cross-sectional study included 68 eyes with primary open-angle glaucoma, 99 eyes with ocular hypertension and 133 control eyes. Corneal biomechanical properties, optic nerve head topographic features, retinal nerve fiber layer thickness, and visual fields were assessed in all cases. Corneal biomechanical properties, retinal nerve fiber layer thicknesses, and optic nerve head topographic features were compared among the groups. The associations between structural and functional measures of glaucomatous damage and corneal biomechanical factors were also evaluated. Results: Significantly lower corneal hysteresis and corneal resistance factor values were observed in the primary open-angle glaucoma and ocular hypertension groups as compared with the control group, but there were no significant differences between the primary open-angle glaucoma and ocular hypertension groups. In the ocular hypertension group, no associations were observed between the corneal hysteresis and corneal resistance factor with values and the structural and functional parameters. In the primary open-angle glaucoma group, positive correlations were observed between the corneal hysteresis values and the global retinal nerve fiber layer thickness (p&lt;0.01, r=0.27), mean retinal nerve fiber layer thickness (p&lt;0.01, r=0.33), and mean deviation (p&lt;0.01, r=0.26), and negative correlations were observed between the corneal resistance factor values, and the cup area (p&lt;0.01, r=-0.39), cup-to-disk ratio (p=0.02, r=-0.28), linear cup-to-disk ratio (p=0.02, r=-0.28), and cup shape (p=0.03, r=-0.26). In the control group, weak correlations were detected between the corneal hysteresis and the cup area (p=0.03, r=0.19), cup-to-disk ratio (p=0.01, r=0.21), and linear cup-to-disk ratio (p=0.01, r=0.22). Conclusions: Distinct correlations were identified between the corneal hysteresis and corneal resistance factor values and the functional and structural parameters in the primary open-angle glaucoma and control groups. Corneal hysteresis and corneal resistance factor may have different roles in the pathophysiology of glaucoma.
DOI: 10.6084/m9.figshare.11267549.v1
title: Capital Structure and Governance Mechanisms External to the Firm: A Cross-Country Analysis

description: Abstract This study investigates whether governance mechanisms external to the firm affect leverage using a sample of 7.490 companies from 40 countries. Our contribution is to separate mechanisms that protect minority shareholders from those that protect creditors rights. Our results show that companies issue debt following the Pecking Order Theory (POT). We find that both mechanisms protecting shareholders and creditors affect corporate leverage. When protection is high, companies issue less debt. Our results are robust to several alternative specifications and variations in our model. We interpret our results as evidence that, when investors are well protected, firms issue less debt, possibly to avoid the monitoring role of debt over the discretion of insiders.
DOI: 10.6084/m9.figshare.11267528
title: Enablers and barriers to environmental management development in higher education institutions: an analysis of sustainability reports of Global Reporting Initiative

description: ABSTRACT This research aims at exploring which characteristics of Higher Education Institutions act as enablers or barriers in the development of environmental management actions. The beta regression analysis of 38 sustainability reports prepared in accordance with the Global Reporting Initiative (GRI) guidelines showed that the institution’s ease of access to financial resources, the existence of an environmental/sustainability plan or policy and the public nature can be considered as enablers for the development of environmental management in HEI, while high complexity of the administrative structure and the existence of several campuses can be understood as barriers to its development. The study helps decision makers understand how the particularities of HEIs and the context in which they operate impact the development of environmental management actions.
DOI: 10.6084/m9.figshare.11267534
title: System for analysis of water abstraction and effluent dilution in Piracicaba river basin, Minas Gerais State, Brazil

description: ABSTRACT The granting of water use rights is one of the main management instruments for the quantitative and qualitative control of water resources. For its implementation, it is necessary, among other actions, to develop tools for integrated analysis of the quantitative and qualitative aspects of water. Thus, the objective of the study was to create a system for the analysis of water abstraction and effluent dilution in the Piracicaba river basin in Minas Gerais. Initially, the survey and preparation of the geographic, hydrological and administrative database were carried out. The system was developed using open-source technologies, with a three-layer structure: data, business, and presentation. According to the results, it was verified that the most critical sections regarding the grantable flow available are located at the mouth and spring of the Piracicaba river. The analysis of the data allowed us to conclude that the system consistently determines the availability of water throughout the hydrography, the dilution flow and discharge unavailability, and identifies stretches of the watercourses with critical water availability, providing support for analyses of the quali-quantitative granting of water resources in the basin.
DOI: 10.6084/m9.figshare.11267540.v1
title: Relationships between corneal biomechanics and the structural and functional parameters of glaucoma damage

description: ABSTRACT Purpose: To investigate the relationships between (i) thickness of the retinal nerve fiber layer, optic nerve head topography, and visual field parameters and (ii) corneal biomechanical properties in normal controls and patients with ocular hypertension and primary open-angle glaucoma. Methods: This observational, cross-sectional study included 68 eyes with primary open-angle glaucoma, 99 eyes with ocular hypertension and 133 control eyes. Corneal biomechanical properties, optic nerve head topographic features, retinal nerve fiber layer thickness, and visual fields were assessed in all cases. Corneal biomechanical properties, retinal nerve fiber layer thicknesses, and optic nerve head topographic features were compared among the groups. The associations between structural and functional measures of glaucomatous damage and corneal biomechanical factors were also evaluated. Results: Significantly lower corneal hysteresis and corneal resistance factor values were observed in the primary open-angle glaucoma and ocular hypertension groups as compared with the control group, but there were no significant differences between the primary open-angle glaucoma and ocular hypertension groups. In the ocular hypertension group, no associations were observed between the corneal hysteresis and corneal resistance factor with values and the structural and functional parameters. In the primary open-angle glaucoma group, positive correlations were observed between the corneal hysteresis values and the global retinal nerve fiber layer thickness (p&lt;0.01, r=0.27), mean retinal nerve fiber layer thickness (p&lt;0.01, r=0.33), and mean deviation (p&lt;0.01, r=0.26), and negative correlations were observed between the corneal resistance factor values, and the cup area (p&lt;0.01, r=-0.39), cup-to-disk ratio (p=0.02, r=-0.28), linear cup-to-disk ratio (p=0.02, r=-0.28), and cup shape (p=0.03, r=-0.26). In the control group, weak correlations were detected between the corneal hysteresis and the cup area (p=0.03, r=0.19), cup-to-disk ratio (p=0.01, r=0.21), and linear cup-to-disk ratio (p=0.01, r=0.22). Conclusions: Distinct correlations were identified between the corneal hysteresis and corneal resistance factor values and the functional and structural parameters in the primary open-angle glaucoma and control groups. Corneal hysteresis and corneal resistance factor may have different roles in the pathophysiology of glaucoma.
DOI: 10.6084/m9.figshare.11267543.v1
title: Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT

description: Abstract Periodontal therapy usually requires local anesthesia. If effective, a non-invasive, liposomal anesthetic gel could increase the levels of acceptance of patients in relation to periodontal therapy. Objective: This study investigated the efficacy of liposomal anesthetic gel for pain control during periodontal therapy. Methodology: Forty volunteers with moderate to severe chronic periodontitis were recruited, of which at least three sextants required periodontal therapy. At least one of the selected teeth had one site with a probing depth of ≥4 mm. The volunteers received the following three gels: a placebo, lidocaine/prilocaine (Oraqix®), or a liposomal lidocaine/prilocaine, which were applied to different sextants. Pain frequency was registered during treatment and the volunteers received a digital counter to register any painful or uncomfortable experiences. At the end of each session, the volunteers indicated their pain intensity using rating scales (NRS-101 and VRS-4). The volunteers had their hemodynamic parameters measured by a non-invasive digital monitor. Results: Pain frequency/intensity did not show statistical difference between intervention groups. The tested gels did not interfere with the hemodynamic indices. Dental anxiety, suppuration and probing depth could influence pain during periodontal therapy. Conclusion: Our results suggest limited indications for the use of non-invasive anesthesia when used for scaling and root planing. Intra-pocket anesthetic gel could be a good option for anxious patients, or those who have a fear of needles.
DOI: 10.6084/m9.figshare.11267516
title: Enhanced antioxidant activity of okara through solid state fermentation of GRAS Fungi

description: Abstract The enhancement of antioxidant activity of fermented okara was investigated using fungal solid-state fermentation. The initial fungal concentration and water activity were found to influence the enhanced antioxidant capacity of fermented okara. Extracellular enzymes, especially proteases and carbohydrases might facilitate the hydrolysis of okara protein that yielded antioxidative amino acids and peptides, as well as the release of isoflavones-derived components. Fermentation of okara with R. oligosporus with 1.04×10-3 gDCW/gokara as initial concentration, water activity of 0.931 was found to yield the highest antioxidant strength. Whereas for A. Oryzae, 1.6×10-3 gDCW/gokara was optimum as the initial concentration with water activity of 0.913. With these optimum conditions, solid-state fermentation of okara could enhance the antioxidant activity up to 2.6- and 5.5-fold, respectively for R. oligosporus and A. oryzae. Besides having an enhanced antioxidant activity, the fermented okara also had higher protein content, amino nitrogen content, and protein digestibility.
DOI: 10.6084/m9.figshare.11267528.v1
title: Enablers and barriers to environmental management development in higher education institutions: an analysis of sustainability reports of Global Reporting Initiative

description: ABSTRACT This research aims at exploring which characteristics of Higher Education Institutions act as enablers or barriers in the development of environmental management actions. The beta regression analysis of 38 sustainability reports prepared in accordance with the Global Reporting Initiative (GRI) guidelines showed that the institution’s ease of access to financial resources, the existence of an environmental/sustainability plan or policy and the public nature can be considered as enablers for the development of environmental management in HEI, while high complexity of the administrative structure and the existence of several campuses can be understood as barriers to its development. The study helps decision makers understand how the particularities of HEIs and the context in which they operate impact the development of environmental management actions.
DOI: 10.6084/m9.figshare.11267534.v1
title: System for analysis of water abstraction and effluent dilution in Piracicaba river basin, Minas Gerais State, Brazil

description: ABSTRACT The granting of water use rights is one of the main management instruments for the quantitative and qualitative control of water resources. For its implementation, it is necessary, among other actions, to develop tools for integrated analysis of the quantitative and qualitative aspects of water. Thus, the objective of the study was to create a system for the analysis of water abstraction and effluent dilution in the Piracicaba river basin in Minas Gerais. Initially, the survey and preparation of the geographic, hydrological and administrative database were carried out. The system was developed using open-source technologies, with a three-layer structure: data, business, and presentation. According to the results, it was verified that the most critical sections regarding the grantable flow available are located at the mouth and spring of the Piracicaba river. The analysis of the data allowed us to conclude that the system consistently determines the availability of water throughout the hydrography, the dilution flow and discharge unavailability, and identifies stretches of the watercourses with critical water availability, providing support for analyses of the quali-quantitative granting of water resources in the basin.
DOI: 10.6084/m9.figshare.11267519
title: New WHO odontogenic tumor classification: impact on prevalence in a population

description: Abstract Objectives: This study approaches the history of reclassifications and redefinitions around the odontogenic keratocyst (OK), as proposed by the World Health Organization (WHO), and aims to understand the impact of those changes on the prevalence and epidemiology of odontogenic tumors (OTs). Methodology: Cases of OTs diagnosed in an Oral Pathology service between January 1996 and December 2016 were reviewed. Demographic data of patients such as age, gender and site of lesions were retrieved from their respective records. Results: Within the studied period, 7,805 microscopic reports were elaborated and 200 (2.56%) of these were diagnosed as OTs. Out of these 200, between 1996 and 2005, prior to the 2005 WHO classification, there were 41 (20.5%) OTs cases, being odontoma the most frequent (23; 56.09%), followed by ameloblastoma (8; 19.51%) and myxoma (03; 7.31%). Between 2006 and 2016, after the previous 2005 WHO classification there were 159 (79.5%) OTs, being odontogenic keratocystic tumor (KCOT) the most frequent (68; 42.76%), followed by odontoma (39; 24.52%) and ameloblastoma (21; 13.20%). Conclusions: As of today, the most recent WHO classification to be followed brings KCOT back to the cyst category, which will impact on the prevalence and epidemiology of OTs; thus, this study was able to identify a considerable increase (287.80%) in the prevalence of OTs when the 2005 WHO classification was utilized. Despite being an important academic exercise, classifying odontogenic lesions and determining whether to place the odontogenic keratocyst in a cyst or tumor category is crucial to establish the correct diagnosis and treatment to follow, whether by oral medicine or oral surgery specialist, or by the general practitioner.
DOI: 10.6084/m9.figshare.11267522
title: Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline

description: ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 females and 9 males). Best-corrected visual acuity was &gt; 20/30 in &gt;90% of patients in both groups and did not change after treatment. After treatment, improvement in ocular symptoms and meibomian gland dysfunction was more pronounced in group B (p&lt;0.05); the other parameters did not reach statistical significance. Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin.
DOI: 10.6084/m9.figshare.11267504
title: Amassing of Hydroxymethylfurfural, 2- Furfural and 5- Methyl furfural in orange (Citrus reticulata) juice during storage

description: Abstract Vitamin C is imperative component of our nutrition and used as additive in many foods owing to its high antioxidant activity. The degradation of vitamin C content in orange juice during storage was evaluated in this study. Degradation of vitamin C in orange juice during 40 days storage at 0, 05, 15, 25, and 40 °C was analyzed and evaluated. Hydroxymethylfurfural (HMF) accumulation in orange juice acts as an indicator of ascorbic acid degradation. The initial vitamin C content in orange juice was 34.26 mg/100 mL that reduced when subjected to various storage conditions such as temperature and time. The loss of vitamin C during storage was lowest at 0 °C and the losses increased with rise in temperature. The Vitamin C content after 40 days in orange juice at 0 °C were 7.19 mg/100 mL while the Vitamin C content reduced to 1.89 mg/100 mL in orange juice that were kept at 40 °C. Hence, with increase in temperature, the Vitamin C was degraded and accretion of HMF, 5 methyl furfural, and 2 methyl furfural was increased. The zero-order interaction between storage time and treatment showed significant influence on HMF.
DOI: 10.6084/m9.figshare.11267510
title: Safety assessment of Spirulina platensis through sprague dawley rats modeling

description: Abstract Health safety of spirulina (Spirulina platensis) for food application was evaluated through hematology and histopathology of liver, spleen and kidney in Sprague Dawley rats fed on three isoproteic diets maintained to 10% protein for forty five days. Three groups of rats were maintained as control diet casein (R-C); diet containing crude spirulina (R-S) and diet containing purified spirulina protein (R-SPI). Hematological profile of the rats group fed on spirulina diets showed no significant increase in white blood cells (WBCs), while there was decreasing trend in the levels of neutrophils (60.46 ± 2.60%) and lymphocytes (33.53 ± 1.06%) in rats that were fed on spirulina diet (R-S) than the other tested experimental diet group. Histopathological examination revealed normal architecture of the liver with no abnormality in kidneys and spleen exhibiting safety of spirulina in both forms to mitigate protein energy malnutrition widely prevalent in developing countries.
DOI: 10.6084/m9.figshare.11267516.v1
title: Enhanced antioxidant activity of okara through solid state fermentation of GRAS Fungi

description: Abstract The enhancement of antioxidant activity of fermented okara was investigated using fungal solid-state fermentation. The initial fungal concentration and water activity were found to influence the enhanced antioxidant capacity of fermented okara. Extracellular enzymes, especially proteases and carbohydrases might facilitate the hydrolysis of okara protein that yielded antioxidative amino acids and peptides, as well as the release of isoflavones-derived components. Fermentation of okara with R. oligosporus with 1.04×10-3 gDCW/gokara as initial concentration, water activity of 0.931 was found to yield the highest antioxidant strength. Whereas for A. Oryzae, 1.6×10-3 gDCW/gokara was optimum as the initial concentration with water activity of 0.913. With these optimum conditions, solid-state fermentation of okara could enhance the antioxidant activity up to 2.6- and 5.5-fold, respectively for R. oligosporus and A. oryzae. Besides having an enhanced antioxidant activity, the fermented okara also had higher protein content, amino nitrogen content, and protein digestibility.
DOI: 10.6084/m9.figshare.11267519.v1
title: New WHO odontogenic tumor classification: impact on prevalence in a population

description: Abstract Objectives: This study approaches the history of reclassifications and redefinitions around the odontogenic keratocyst (OK), as proposed by the World Health Organization (WHO), and aims to understand the impact of those changes on the prevalence and epidemiology of odontogenic tumors (OTs). Methodology: Cases of OTs diagnosed in an Oral Pathology service between January 1996 and December 2016 were reviewed. Demographic data of patients such as age, gender and site of lesions were retrieved from their respective records. Results: Within the studied period, 7,805 microscopic reports were elaborated and 200 (2.56%) of these were diagnosed as OTs. Out of these 200, between 1996 and 2005, prior to the 2005 WHO classification, there were 41 (20.5%) OTs cases, being odontoma the most frequent (23; 56.09%), followed by ameloblastoma (8; 19.51%) and myxoma (03; 7.31%). Between 2006 and 2016, after the previous 2005 WHO classification there were 159 (79.5%) OTs, being odontogenic keratocystic tumor (KCOT) the most frequent (68; 42.76%), followed by odontoma (39; 24.52%) and ameloblastoma (21; 13.20%). Conclusions: As of today, the most recent WHO classification to be followed brings KCOT back to the cyst category, which will impact on the prevalence and epidemiology of OTs; thus, this study was able to identify a considerable increase (287.80%) in the prevalence of OTs when the 2005 WHO classification was utilized. Despite being an important academic exercise, classifying odontogenic lesions and determining whether to place the odontogenic keratocyst in a cyst or tumor category is crucial to establish the correct diagnosis and treatment to follow, whether by oral medicine or oral surgery specialist, or by the general practitioner.