cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6801119.v3
title: Genome-wide analysis of NGS data to compile cancer-specific panels of miRNA biomarkers

description: MicroRNAs are small non-coding RNAs that influence gene expression by 
binding to the 3' UTR of target mRNAs in order to repress protein 
synthesis. Soon after discovery, microRNA dysregulation has been 
associated to several pathologies. In particular, they have often been 
reported as differentially expressed in healthy and tumor samples. This 
fact suggested that microRNAs are likely to be good candidate biomarkers
 for cancer diagnosis and personalized medicine. With the advent of 
Next-Generation Sequencing (NGS), measuring the expression level of the 
whole miRNAome at once is now routine. Yet, the collaborative effort of 
sharing data opens to the possibility of population analyses. This 
context motivated us to perform an in-silico study to distill 
cancer-specific panels of microRNAs that can serve as biomarkers. We 
observed that the problem of finding biomarkers can be modeled as a 
two-class classification task where, given the miRNAomes of a population
 of healthy and cancerous samples, we want to find the subset of 
microRNAs that leads to the highest classification accuracy. We fulfill 
this task leveraging on a sensible combination of data mining tools. In 
particular, we used: differential evolution for candidate selection, 
component analysis to preserve the relationships among miRNAs, and SVM 
for sample classification. We identified $10$ cancer-specific panels 
whose classification accuracy is always higher than 92%. These panels 
have a very little overlap suggesting that miRNAs are not only 
predictive of the onset of cancer, but can be used for classification 
purposes as well. We experimentally validated the contribution of each 
of the employed tools to the selection of discriminating 
miRNAs.Moreover, we tested the significance of each panel for the 
corresponding cancer type. In particular, enrichment analysis showed 
that the selected miRNAs are involved in oncogenesis pathways, while 
survival analysis proved that miRNAs can be used to evaluate cancer 
severity. Summarizing: results demonstrated that our method is able to 
produce cancer-specific panels that are promising candidates for a 
subsequent in vitro validation.
DOI: 10.6084/m9.figshare.6801119.v2
title: BRCA_miRNA.xlsx

description: MicroRNAs are small non-coding RNAs that influence gene expression by binding to the 3' UTR of target mRNAs in order to repress protein synthesis. Soon after discovery, microRNA dysregulation has been associated to several pathologies. In particular, they have often been reported as differentially expressed in healthy and tumor samples. This fact suggested that microRNAs are likely to be good candidate biomarkers for cancer diagnosis and personalized medicine. With the advent of Next-Generation Sequencing (NGS), measuring the expression level of the whole miRNAome at once is now routine. Yet, the collaborative effort of sharing data opens to the possibility of population analyses. This context motivated us to perform an in-silico study to distill cancer-specific panels of microRNAs that can serve as biomarkers. We observed that the problem of finding biomarkers can be modeled as a two-class classification task where, given the miRNAomes of a population of healthy and cancerous samples, we want to find the subset of microRNAs that leads to the highest classification accuracy. We fulfill this task leveraging on a sensible combination of data mining tools. In particular, we used: differential evolution for candidate selection, component analysis to preserve the relationships among miRNAs, and SVM for sample classification. We identified $10$ cancer-specific panels whose classification accuracy is always higher than 92%. These panels have a very little overlap suggesting that miRNAs are not only predictive of the onset of cancer, but can be used for classification purposes as well. We experimentally validated the contribution of each of the employed tools to the selection of discriminating miRNAs.Moreover, we tested the significance of each panel for the corresponding cancer type. In particular, enrichment analysis showed that the selected miRNAs are involved in oncogenesis pathways, while survival analysis proved that miRNAs can be used to evaluate cancer severity. Summarizing: results demonstrated that our method is able to produce cancer-specific panels that are promising candidates for a subsequent in vitro validation.
DOI: 10.6084/m9.figshare.6801119
title: Genome-wide analysis of NGS data to compile cancer-specific panels of miRNA biomarkers

description: MicroRNAs are small non-coding RNAs that influence gene expression by 
binding to the 3' UTR of target mRNAs in order to repress protein 
synthesis. Soon after discovery, microRNA dysregulation has been 
associated to several pathologies. In particular, they have often been 
reported as differentially expressed in healthy and tumor samples. This 
fact suggested that microRNAs are likely to be good candidate biomarkers
 for cancer diagnosis and personalized medicine. With the advent of 
Next-Generation Sequencing (NGS), measuring the expression level of the 
whole miRNAome at once is now routine. Yet, the collaborative effort of 
sharing data opens to the possibility of population analyses. This 
context motivated us to perform an in-silico study to distill 
cancer-specific panels of microRNAs that can serve as biomarkers. We 
observed that the problem of finding biomarkers can be modeled as a 
two-class classification task where, given the miRNAomes of a population
 of healthy and cancerous samples, we want to find the subset of 
microRNAs that leads to the highest classification accuracy. We fulfill 
this task leveraging on a sensible combination of data mining tools. In 
particular, we used: differential evolution for candidate selection, 
component analysis to preserve the relationships among miRNAs, and SVM 
for sample classification. We identified $10$ cancer-specific panels 
whose classification accuracy is always higher than 92%. These panels 
have a very little overlap suggesting that miRNAs are not only 
predictive of the onset of cancer, but can be used for classification 
purposes as well. We experimentally validated the contribution of each 
of the employed tools to the selection of discriminating 
miRNAs.Moreover, we tested the significance of each panel for the 
corresponding cancer type. In particular, enrichment analysis showed 
that the selected miRNAs are involved in oncogenesis pathways, while 
survival analysis proved that miRNAs can be used to evaluate cancer 
severity. Summarizing: results demonstrated that our method is able to 
produce cancer-specific panels that are promising candidates for a 
subsequent in vitro validation.
DOI: 10.6084/m9.figshare.6801119.v1
title: BRCA_miRNA.xlsx

description: Datasets that are used in this article "Genome-wide analysis of NGS data to compile cancer-specific panels of miRNA biomarkers"<br>
DOI: 10.15468/dl.sarsgs
title: Occurrence Download

description: A dataset containing 43 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Thunnus albacares (Bonnaterre, 1788)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 43 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031520-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28015544
title: Masterchart and code

description: Title:Psychiatric morbidity and suicidality in individuals 6 months after a suicide attempt: a descriptive study in a tertiary hospital in South India
DOI: 10.6084/m9.figshare.6466124.v48
title: Popper test archive

description: A short description of the article
DOI: 10.6084/m9.figshare.6466124.v49
title: Popper test archive

description: A short description of the article
DOI: 10.6084/m9.figshare.6466124.v50
title: Popper test archive

description: A short description of the article
DOI: 10.15468/dl.b8x585
title: Occurrence Download

description: A dataset containing 13270 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Machine Observation, Observation, Specimen)",
 "Continent is Asia",
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Mammalia, Reptilia)",
 "Year 1980-2024"
 ]
}

 The dataset includes 13270 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031519-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.6479504.v1
title: GWAS DATA

description: This dataset included phenotype data and genetype data for our analysis. <br>
DOI: 10.6084/m9.figshare.6263858.v1
title: Source data for a study exploring production impacts of a 100% organic conversion in England and Wales

description: Underlying data for ‘Modelling the production impacts of a widespread conversion to organic agriculture in England and Wales’ by L.G. Smith et al. (2018). We develop and apply a bespoke model, the Optimal Land Use Model (OLUM) to estimate levels of production from agriculture in England and Wales under organic management . Outputs under a range of scenarios are compared to the real-world distribution of conventional production in 2010.
DOI: 10.15468/dl.5u595w
title: Occurrence Download

description: A dataset containing 401 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Spratelloides gracilis (Temminck & Schlegel, 1846)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 401 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031521-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xphkva
title: Occurrence Download

description: A dataset containing 2428507 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Specimen, Human Observation)",
 "TaxonKey is Papaveraceae"
 ]
}

 The dataset includes 2428507 records from 4654 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031516-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25582/data.2024-03.3075821/2543455
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/jas-tx0-1xe
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/p9s-6x6-xf3
title: †Esthoniopora subspherica (Bassler, 1911)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/1b0-fl0-5ly
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/t42-j4n-gl2
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/l0g-k6j-645
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/sh0-81f-zr1
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075822/2543456
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/smq-vtm-2wp
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/dng-63k-69c
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/w07-y6y-k7d
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/adk-etn-tgj
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/b9h-lrw-1v3
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075823/2543457
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/jf1-fkv-r02
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/tha-as7-lmg
title: †Lioclemella spinea (Bassler, 1911)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/p4j-591-5s4
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/swn-h4q-1zg
title: Anoigmaichnus? sp.

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/4sy-rge-1c5
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/khp-mma-laj
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075824/2543458
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/nhj-vhv-wmm
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zkb-475-544
title: †Stigmatella massalis Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/pw8-jqz-w2k
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/sw9-ts7-qmv
title: †Lioclemella spinea (Bassler, 1911)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/s16-z1w-eez
title: †Hemiphragma panderi (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075826/2543459
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/kbe-njy-wh2
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/mpb-qw7-yqp
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/b05-djr-p2b
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/xam-01b-qlt
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/42a-ptk-yw1
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/jkf-avq-ejj
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075830/2543460
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/bx8-585-c9m
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ger-am1-2jp
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0y5-f34-m14
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/lmt-m6q-8t1
title: †Dybowskites clavus (Bassler, 1911)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7t9-6ht-p7b
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/95a-7pr-rde
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075833/2543461
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/39d-t6v-ymk
title: †Lioclemella clava Grubbs, 1939

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0ev-f8a-j93
title: †Hemiphragma panderi (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/1d8-xrh-1zj
title: †Hemiphragma panderi (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/65m-ary-atd
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vpc-93e-crw
title: †Hemiphragma panderi (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075835/2543462
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/38n-kmf-6y0
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/c9n-2ac-5aa
title: †Hemiphragma panderi (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/9rt-qf7-351
title: †Hemiphragma panderi (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/t7j-hkq-wgx
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/mfy-wld-wb9
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/r4d-az3-qwb
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/0kb-rg5-k25
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/n7q-tae-ps6
title: †Revalopora revalensis (Dybowski, 1877)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075836/2543463
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/n29-ny6-x1l
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/51b-61n-m2j
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ta4-p86-z1e
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/25k-54m-797
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6xc-ann-r61
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075837/2543464
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/c1f-cxg-vnh
title: †Anaphragma mirabile cognatum Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gka-hzy-kqz
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/hvb-kfg-rv9
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/yzk-3x3-8mb
title: †Anaphragma mirabile cognatum Bassler, 1911

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/1bk-ala-9g3
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ybx-a3l-yhs
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075838/2543465
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/d6a-5nl-2s9
title: †Batostoma Ulrich, 1882

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/58m-sk2-ds8
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/d0a-1ef-11m
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/gwv-983-sn1
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zkl-v0l-b64
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075839/2543466
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/0wn-srp-n81
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/a1y-sk7-0e5
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/vy6-1rt-esl
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/3w4-xxs-hav
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/l8j-m0q-hwt
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/6yt-lz8-dc4
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/eq6-mtw-4w7
title: †Mesotrypa excentrica Modzalevskaya, 1953

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075840/2543467
title: Data for EMSL Project 51287 from March 2024
DOI: 10.3535/bs9-bpv-p6b
title: †Batostoma Ulrich, 1882

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/15v-d43-4n4
title: †Bythopora subgracilis (Ulrich, 1893)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/7eh-r8t-8vw
title: †Eridotrypa aedilis (Eichwald, 1855)

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/ntn-zet-s6x
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.3535/zz5-w6z-seb
title: †Batostoma Ulrich, 1882

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.25582/data.2024-03.3075841/2543468
title: Data for EMSL Project 51287 from March 2024