cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.26036/cnp0000194
title: Klebsiella Pneumoniae raw sequence reads

description: Morphological Changes of Bacteria Under the Impact of Antibiotics
DOI: 10.26036/cnp0000195
title: HIFI-Barcode-se400

description: Here we introduce a single-end 400bp sequencing strategy in BGISEQ-500 platform, which allow us to generates full-length reference barcodes via simply connection of 5’ and 3’ reads. Briefly, individual genomic DNA was extracted separately and amplified on a 96-well plate using 96 sets of uniquely tagged primers. Amplicons were then pooled, without fragment, and sequenced on BGISEQ-500 platform at 400 SE. Mixed HTS reads were assembled using a customized bioinformatics pipeline to obtain the barcode sequence for each individual. Compared with the available HTS platforms, our method had a more concise library construction strategy and easier analysis practice and most cost-effective.
DOI: 10.26036/cnp0000198
title: An ATAC-seq atlas of chromatin accessibility in mouse tissues

description: Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is a fundamental epigenomics approach and has been widely used in profiling the chromatin accessibility dynamics in mammalian species, such as human and mouse. However, a comprehensive reference ATAC-seq dataset source of adult mouse tissues is still lacking, hampering the discovery of tissue-specific accessible elements. Here, we report on a mouse ATAC-seq atlas by producing a total of 66 ATAC-seq profiles from 20 primary tissues of both male and female mice. The ATAC-seq read enrichment, fragment size distribution and reproducibility between replicates revealed high quality of the full datasets. We finally identified a sum of 296,574 accessible elements. We further identified key transcription factors specific to distinct tissues and found that the enrichment of each transcription factor can well reflect the developmental distance across tissues. In summary, our study provided an important resource on mouse epigenome and will be of high-value in various studies such as development, cell reprogramming and genetic diseases.
DOI: 10.26036/cnp0000203
title: Evolution of viviparity: Genomic and transcriptomic investigations of the transition from egg-laying to live birth

description: Viviparous (live-bearing) vertebrates have evolved repeatedly within otherwise oviparous(egg-laying) clades. The oviparity to viviparity transition requires numerous physiological,morphological, and immunological changes to the female reproductive tract, including eggshellreduction; delayed oviposition; placental development for supply of water and nutrition to theembryo by the mother; enhanced gas exchange; and suppression of maternal immune rejection ofthe embryo. Genomic and transcriptomic analyses of a closely related oviparous–viviparous pairof lizards (Phrynocephalus przewalskii and P. vlangalii) reveal the changes that account for thesetransitions. In addition, we compared the gene sequences in transcriptomes of four oviparous–viviparous pairs of lizards in different genera to look for possible gene convergence at thesequence level.
DOI: 10.26036/cnp0000209
title: Whole genome sequencing of 6 woolly mammoths

description: Six woolly mammoth samples were collected from Siberia and were sequenced using BGISEQ-500 platform.
DOI: 10.26036/cnp0000212
title: P18Z10200N0175

description: We sequenced de novo and assembled three industrial chlorella genomes, including Chlorella sorokiniana BD09, Chlorella sorokiniana BD08 and Chlorlella sp. Dachan, which are widely used for nutrient removal from piggery wastewater. The three newly sequenced genomes have been presented in a high genome assembly quality in contiguity comparable with previously published chlorella elsewhere.
DOI: 10.26036/cnp0000220
title: 甘蔗抗卷叶病

description: 通过RNA-seq比较分析甘蔗卷叶病抗病和易感病品种的转录组差异，揭示抗病感病机理
DOI: 10.26036/cnp0000222
title: whole genome sequencing of Sebastes schlegelii

description: Black rockfish (Sebastes schlegelii), belonging to Scorpaenidae, widely distributes the coastal waters of China, Japan, and Korea . Efforts for stock enhancement by releasing the juvenile has been made since 1980s. Many studies has been carried out on its viviparous breeding habits and aquaculture values . Black rockfish (Sebastes schlegelii), as one example species of Sebastes, fertilize internal and give birth to free-living fish. Copulation occurs in November and December while fertilization completes in April, so sperm will be preserved within female’s body for almost six months. This phenomenon of sperm storage is typically found in animals in which the time of mating does not synchronize with the time of ovulation in the female. Although it is reported in several taxa for insects , reptiles, birds and mammals, the mechanism has yet to be fully elucidated.
DOI: 10.26036/cnp0000223
title: 单细胞技术开发与应用

description: 该项目拟开发新型单细胞技术，实现高通量单细胞分析，并应用于医疗上。
DOI: 10.26036/cnp0000229
title: Genome of evolutionary nodal fishes

description: By sequencing the whole genome of nodal fishes, the development and evolution of nodal fishes were studied.
DOI: 10.26036/cnp0000233
title: RNA-seq of Vermivorous Oak Cone Snail (Conus quercinus)

description: RNA-seq of Vermivorous Oak Cone Snail (Conus quercinus)
DOI: 10.26036/cnp0000189
title: Whole genome resequencing of important Bos indicus breeds from Pakistan

description: Whole genome resequencing of Bos.indicus from Pakistan is a project of identifying sequencing based genome wide variations across the important B.indicus breeds of Pakistan. It is a collaborative project between NIBGE, Pakistan and BGI Shenzhen and is started in 2014.
DOI: 10.26036/cnp0000228
title: Green Algae

description: The genomes of early-branching streptophyte green algae shed light on the dawn of plant terrestrialization
DOI: 10.26036/cnp0000166
title: The Urinary Microbiota in Relation to the Reproductive Tract Microbiota

description: Here we report the urinary microbiota for a relatively large cohort of 152 women of reproductive age. Together with our recently published peritoneal fluid, uterine and vaginal samples from the same individuals, we show that although with greater amounts of Lactobacillus and Streptococcus, the urinary microbiota is similar to the reproductive tract, in accordance with the anatomical opening of the bladder. Together with a wealth of metadata, we also explore the potential of the urinary microbiota for diagnosis.
DOI: 10.26036/cnp0000235
title: RNA-seq of stingray

description: RNA-seq of stingray venom and comparative analysis
DOI: 10.26036/cnp0000236
title: Landscape of Endoderm and Liver Developmental Lineage Revealed by Single-Cell RNA Sequencing

description: Here, we construct a transgenic Foxa2-eGFP reporter mouse line and performed deep single-cell RNA sequencing on 1,966 individual cells isolated from the fluorescent endoderm and hepatic regions from ten embryonic stages, ranging from day E7.5 to E15.5. We identified the embryonic liver developmental trajectory origin from primitive streak, and characterized the transcriptome of the hepatic lineage.
DOI: 10.26036/cnp0000241
title: Acipenser ruthenus Genome sequencing and assembly

description: Acipenser ruthenus Genome sequencing and assembly
DOI: 10.26036/cnp0001478
title: Sinocyclocheilus grahami genome

description: Sinocyclocheilus grahami chromosome-level genome assembly results
DOI: 10.26036/cnp0000248
title: 非洲猪瘟病毒安徽省宣城市古泉镇2018年株

description: 2018年在安徽省宣城市古泉镇采集到的病毒样本，采用二代测序，并组装得到非洲猪瘟的全基因组序列
DOI: 10.26036/cnp0000281
title: 牡丹基因组测序、组装和注释

description: 牡丹是世界闻名的园艺花卉，具有极高的观赏价值。由于牡丹的基因组很大（约13Gb-15Gb),全基因组测序及组装一直是尚未解决的难题，参考基因组缺失导致人们对其遗传信息的了解甚少，妨碍了其育种进展，我们通过三代测序技术获得了大约67x的覆盖度的基因组序列，并用falcon软件将其组装成499,789 contigs，全长为13.78Gb，包含35,687个预测的基因。
DOI: 10.26036/cnp0000261
title: Cadmium Resistance E.coli strains

description: Cadmium (Cd) is a heavy metal that is extremely toxic to many organisms; however, microbes are highly adaptable to extreme conditions, including heavy metal contamination. Bacteria can evolve in the natural environment, generating resistant strains that can be studied to understand heavy metal resistance mechanisms, but obtaining such adaptive strains usually takes a long time. In this study, the genome replication engineering-assisted continuous evolution (GREACE) method was used to accelerate the evolutionary rate of the Escherichia coli genome to screen for E. coli mutants with high resistance to cadmium.
DOI: 10.26036/cnp0000264
title: The Genome assembly of asparagus bean

description: Asparagus bean (Vigna. unguiculata ssp. sesquipedialis), known for its very long and tender green pods, is an important vegetable crop broadly grown in the developing countries. Despite its agricultural and economic values, asparagus bean does not have a high-quality genome assembly for breeding novel agronomic traits. In this study, we reported a high-quality 632.8 Mb assembly of asparagus bean based on the whole genome shotgun sequencing strategy. We also generated a high-density linkage map for asparagus bean, which helped anchor 94.42% of the scaffolds into 11 pseudo-chromosomes. A total of 42,609 protein-coding genes and 3,579 non-protein-coding genes were predicted from the assembly. Taken together, these genomic resources of asparagus bean will facilitate the investigation of economically valuable traits in a variety of legume species, so that the cultivation of these plants would help combat the protein and energy malnutrition in the developing world.
DOI: 10.26036/cnp0000269
title: 基于全基因组测序的被子植物系统进化研究

description: 杜鹃花作为世界著名观赏植物，具有重要的科学、生态和经济价值。然而由于其经历了快速的辐射演化与频繁的自然杂交，给杜鹃花属植物准确的科学分类与物种鉴定带来了一定困难，这在一定程度上制约了我国杜鹃花资源的挖掘与利用。本研究通过对中国杜鹃花属6 个亚属85 个种的RAD-seq 高通量测序和基于这些数据的群体遗传学分析，探讨RAD-seq 技术在复杂类群分类与物种界定方面的优势。本研究中85 份材料比对到马缨杜鹃的平均比对率87.52%，在参考基因组上的平均覆盖度为5.21%，最终获得了620,423 个SNP 标记。初步的PCA、Structure 聚类及系统发育树的分析结果在亚属水平（杜鹃亚属、常绿杜鹃亚属、马银花亚属、羊踯躅亚属、映山红亚属和长蕊杜鹃亚属）基本支持目前形态学的分类处理，突出了鳞片在杜鹃属植物分类中的重要作用。
DOI: 10.26036/cnp0000277
title: Complete mitochondrial genome sequences of 5 woolly mammoths

description: Complete mitochondrial genome sequences of 5 woolly mammoths were assembled by using the whole genome sequences downloaded from the accession number of CNP0000209
DOI: 10.26036/cnp0000284
title: metagenomic study revealed the potential role of gout microbiome for gout

description: Gout is a common inflammatory arthritis disease caused by the chronic evaluated level of uric acid and the subsequent deposited urate crystals in and around joints. Emerging evidences have shown that gut microbiota is associated with numerous human diseases. However, the relationship between gout and microbiota still remains unclear. Here we performed a metagenomic study to reveal the differential microbial signature in gout patients and assess the association between gout and gut microbiome.
DOI: 10.26036/cnp0000288
title: RNA demo data

description: MGISEQ-2000 lncRNA and smallRNA demo data(Raw data and clean data)
DOI: 10.26036/cnp0000292
title: Musa balbisiana Genome sequencing and assembly

description: We present a draft genome assembly of Musa balbisiana, representing the putative progenitor or contributor of the B-subgenome to triploid cultivar bananas.
DOI: 10.26036/cnp0000293
title: P17Z10200N0249

description: 未习惯高原环境的人进入高海拔地区后极易发生急性高原反应。主要症状是急性低压缺氧通过对神经系统的损伤导致AMS和HACE的各种神经生理的临床症状，由于神经元的不可再生性，因此急性高原反应会造成严重损害。但目前为止，高原疾病的具体机制仍不明确。 常用的实验动物大鼠与小鼠对低压缺氧有较强的耐受性，不适合作为高原疾病的动物模型。灵长类与人有相似的大脑结构，适合作为动物模型; 目前食蟹猴基因组已经完成测序，利于我们进一步在组学水平上研究食蟹猴机制。 高原疾病缺乏合适的预防性药物，唯一批准的乙酰唑胺是磺胺类药物，其本身就有较高的过敏反应发生率; 也会造成认知伤害。因此我们使用食蟹猴实验探索两种內源性神经保护甾体对高原疾病的预防作用，两种甾体分别是孕酮和胆甾三醇(cholestane-3β,5α,6β-Triol)。
DOI: 10.26036/cnp0000295
title: 鹅掌楸基因组信息采集

description: 鹅掌楸基因组及注释结果
DOI: 10.26036/cnp0000297
title: Low Frequency Mutation Detector

description: A new method to detect low frequency mutations with high-depth NGS data.
DOI: 10.26036/cnp0000299
title: 关键进化节点鱼类的全基因组测序技术研发

description: 关键进化节点鱼类的全基因组测序技术研发
DOI: 10.26036/cnp0000302
title: genome of the Siamese fighting fish

description: Siamese fighting fish Betta splendens are notorious for their aggressiveness and accordingly have been widely used to study aggression. However, the lack of a reference genome has so far limited the understanding of the genetic basis of aggression in this species. Here we present the first reference genome assembly of the Siamese fighting fish.
DOI: 10.26036/cnp0000304
title: Transcriptome of Paralichthys olivaceus during the development

description: This research is aim to analyze the different phage during the development and growth of flounder (Paralichthys olivaceus), and further find the molecular mechanism about the development.
DOI: 10.26036/cnp0000303
title: 三七材料基因分型

description: 对1081份云南三七（Panax notoginseng）和375份越南三七（Panax vietnamensis）资源材料进行RAD测序，开发多态性分子标记，分析群体结构并对6个重要农艺性状进行全基因组关联分析（GWAS）。
DOI: 10.26036/cnp0000305
title: Buffalo embryo development RNA-seq

description: Global Transcriptome Analysis of Different Stages of Preimplantation Embryo Development in River Buffalo
DOI: 10.26036/cnp0000308
title: Killifish transcriptome

description: Killifish transcriptome
DOI: 10.26036/cnp0000854
title: Deep-sea snails

description: Sequenced and assembled two deep-sea snails.
DOI: 10.26036/cnp0000314
title: F15FTSSCKF0577+市二院12个人lncRNA信息采集

description: 本研究采用丹麦哥本哈根大学，Jan Stenvang实验室构建的乳腺癌的耐药性细胞系（抗紫杉醇的MCF-7和MDA-MB-231）提取的RNA 为研究材料，通过去核糖体链特异性建库转录组测序技术，采集细胞系转录组信息。全面分析耐药细胞里面的mRNA和lncRNA的表达情况。寻找耐药和正常细胞系中差异表达的lncRNA，分析其与外显子突变，mRNA表达的关系，全面深入分析耐药性产生的分子机理。寻找克服紫杉醇耐药的新靶标
DOI: 10.26036/cnp0000315
title: 狮子鱼组学研究

description: 狮子鱼基因组以及转录组学研究
DOI: 10.5517/ccdc.csd.cc270gzq
title: CCDC 2056043: Experimental Crystal Structure Determination

description: Related Article: Marion Till, John A. Kelly, Christoph G. P. Ziegler, Robert Wolf, Tianao Guo, Mark R. Ringenberg, Eugen Lutsker, Oliver Reiser|2021|Organometallics|40|1042|doi:10.1021/acs.organomet.1c00042
DOI: 10.26036/cnp0000317
title: 非洲茄基因组及重测序

description: Background: S. aethiopicum is a close relative to S. melongena and has been routinely used to improve disease resistance in S. melongena. However, these efforts have been greatly limited by the lack of a reference genome and the clear understanding of the genes involved during biotic and abiotic stress response. Results: We present here a draft genome assembly of S. aethiopicum of 1.02 Gb in size. Our data shows that 76.2% of the genome is occupied by repetitive sequences, predominantly long terminal repeat elements. We annotated 37,681 gene models including 34,905 protein-coding genes. We observed an expansion of resistance genes through two rounds of amplification of LTRs, which may have occurred around 1.25 and 3.5 million years ago, respectively. The expansion also occurred in gene families related to drought tolerance. Re-sequencing of 65 S. aethiopicum genotypes, 41,046 SNPs are closely linked to resistance genes. The domestication and demographic history inferred a selection of genes involved in drought tolerance in both “Gilo” and “Shum” groups. A pan-genome of S. aethiopicum with a total of 36,250 protein-coding genes was assembled, of which 1,345 genes are missing in the reference genome. Conclusions: Overall, the genome sequence of S. aethiopicum increases our understanding of the genomic mechanisms of its extraordinary disease resistance and drought tolerance. The SNPs identified are available for potential use by breeders. The information provided here will greatly accelerate the selection and breeding of the African eggplant as well as other crops within the Solanaceae family.
DOI: 10.5517/ccdc.csd.cc270h0s
title: CCDC 2056044: Experimental Crystal Structure Determination

description: Related Article: Marion Till, John A. Kelly, Christoph G. P. Ziegler, Robert Wolf, Tianao Guo, Mark R. Ringenberg, Eugen Lutsker, Oliver Reiser|2021|Organometallics|40|1042|doi:10.1021/acs.organomet.1c00042
DOI: 10.5517/ccdc.csd.cc270h2v
title: CCDC 2056046: Experimental Crystal Structure Determination

description: Related Article: Marion Till, John A. Kelly, Christoph G. P. Ziegler, Robert Wolf, Tianao Guo, Mark R. Ringenberg, Eugen Lutsker, Oliver Reiser|2021|Organometallics|40|1042|doi:10.1021/acs.organomet.1c00042
DOI: 10.26036/cnp0000340
title: De novo assembly of the Mongolian gerbil genome and transcriptome

description: BACKGROUND: The Mongolian gerbil (Meriones unguiculatus) has historically been used as a model organism for the auditory and visual systems, stroke/ischemia, epilepsy and aging related research since 1935 when laboratory gerbils were separated from their wild counterparts. In this study we report genome sequencing, assembly, and annotation further supported by transcriptome data from 27 different tissues samples. FINDINGS: The genome was assembled using Illumina HiSeq 2000 and resulted in a final genome size of 2.54 Gbp with contig and scaffold N50 values of 31.4 Kbp and 500.0 Kbp, respectively. Based on the k-mer estimated genome size of 2.48 Gbp, the assembly appears to be complete. The genome annotation was supported by transcriptome data that identified 36 019 predicted protein-coding genes across 27 tissue samples. A BUSCO search of 3023 mammalian groups resulted in 86% of curated single copy orthologs present among predicted genes, indicating a high level of completeness of the genome. CONCLUSIONS: We report a de novo assembly of the Mongolian gerbil genome that was further enhanced by annotation of transcriptome data from several tissues. Sequencing of this genome increases the utility of the gerbil as a model organism, opening the availability of now widely used genetic tools.
DOI: 10.26036/cnp0000343
title: 集成式肠道致病菌血清型分子鉴定系统的研发及应用

description: 霍乱、伤寒、副伤寒、痢疾以及其他感染性腹泻仍然是影响人类健康的重要疾病。这些疾病主要由O1群、O139群霍乱弧菌；伤寒、副伤寒是由伤寒沙门菌和甲、乙、丙型副伤寒沙门菌、志贺菌属等食源性致病菌引起。病原菌培养、血清学、PFGE等传统检测手段耗时耗力，操作繁琐，通量低，灵敏度低；近年来，细菌基因组测序和研究发展迅速，但国内肠道致病菌研究薄弱，因此亟需通过国内尤其是以广东地区为起点对历年流行的肠道致病菌进行测序和比较基因组学研究，阐明广东乃至国内其他区域肠道致病菌的群体结构、致病力、耐药的分子特征、流行病学、宿主特异性、基因型多样性和发病机制；并在此基础上，在全基因组水平，与全球肠道致病菌基因组数据比较分析，鉴定和筛选高分辨的分型溯源基因和位点，为开发肠道致病菌的监测防控、耐药毒力传播预测和临床诊疗技术奠定基础。
DOI: 10.26036/cnp0000316
title: Microbiome of Moutai Daqu

description: Moutai is one of the most famous Chinses liquors. The microbial community and activity of Moutai Daqu, the fermentation starter, have not been fully understood yet. Here, 16S rRNA gene V4-V5 amplicon sequencing was performed on a total of 185 Moutai Daqu samples and shotgun metagenomic sequencing on five of these samples.
DOI: 10.5517/ccdc.csd.cc273jlh
title: CCDC 2058976: Experimental Crystal Structure Determination

description: Related Article: Huiguang Dai, Weishi Li, Jeanette A. Krause, Hairong Guan|2021|Inorg.Chem.|60|6521|doi:10.1021/acs.inorgchem.1c00328
DOI: 10.26036/cnp0000347
title: RNA-seq analysis of quercetin-treated rice roots

description: Flavonoids play import roles in root development and its tropic responses. Whereas flavonoid-mediated changes of global gene transcription levels during root growth remains unclear. Here global transcription changes in quercetin-treated rice primary roots were analyzed using RNA-seq.
DOI: 10.5517/ccdc.csd.cc273jmj
title: CCDC 2058977: Experimental Crystal Structure Determination

description: Related Article: Huiguang Dai, Weishi Li, Jeanette A. Krause, Hairong Guan|2021|Inorg.Chem.|60|6521|doi:10.1021/acs.inorgchem.1c00328
DOI: 10.5517/ccdc.csd.cc273jnk
title: CCDC 2058978: Experimental Crystal Structure Determination

description: Related Article: Huiguang Dai, Weishi Li, Jeanette A. Krause, Hairong Guan|2021|Inorg.Chem.|60|6521|doi:10.1021/acs.inorgchem.1c00328
DOI: 10.26036/cnp0000360
title: Transcriptome sequencing of three conus species

description: Transcriptome sequencing of three vermivorous conus species
DOI: 10.26036/cnp0000364
title: Saccharina japonica genome

description: We constructed pseudo-chromosomes by combining a genetic linkage map with scaffold information .
DOI: 10.26036/cnp0000366
title: 红树林根系微生物

description: The rhizosphere microorganisms composition and function of mangrove plants were studied mainly by metagenomic sequencing and analysis.
DOI: 10.5517/ccdc.csd.cc273jvr
title: CCDC 2058984: Experimental Crystal Structure Determination

description: Related Article: Huiguang Dai, Weishi Li, Jeanette A. Krause, Hairong Guan|2021|Inorg.Chem.|60|6521|doi:10.1021/acs.inorgchem.1c00328
DOI: 10.5517/ccdc.csd.cc273jws
title: CCDC 2058985: Experimental Crystal Structure Determination

description: Related Article: Huiguang Dai, Weishi Li, Jeanette A. Krause, Hairong Guan|2021|Inorg.Chem.|60|6521|doi:10.1021/acs.inorgchem.1c00328
DOI: 10.26036/cnp0000368
title: BGISEQ NA12878 WGS

description: A dataset of NA12878/HG001 from BGISEQ sequencer . There are four runs in this dataset. They are PCR library PE100, PCR library PE150, PCR-free library PE100 and PCR-free library PE150
DOI: 10.5517/ccdc.csd.cc273jxt
title: CCDC 2058986: Experimental Crystal Structure Determination

description: Related Article: Huiguang Dai, Weishi Li, Jeanette A. Krause, Hairong Guan|2021|Inorg.Chem.|60|6521|doi:10.1021/acs.inorgchem.1c00328
DOI: 10.5517/ccdc.csd.cc274dxq
title: CCDC 2059823: Experimental Crystal Structure Determination

description: Related Article: Huaanzi Hu, Yan Peng, Ting Yu, Sidi Cheng, Shuang Luo, Qiang Zhu|2021|Org.Lett.|23|3636|doi:10.1021/acs.orglett.1c01036
DOI: 10.26036/cnp0000370
title: Re-sequencing of chickpea reference set

description: In order to harness the genome sequence for chickpea improvement, 300 chickpea genotypes of diverse origin were re-sequenced at 5X to 13X coverage.
DOI: 10.26036/cnp0000375
title: Whole genome sequencing of Lactobacillus plantarum LLY-606

description: Genome analysis of two Lactobacillus plantarum strains, LLY-606 and pc-26, a pre-evaluation for their potential as probiotics
DOI: 10.5517/ccdc.csd.cc276jzz
title: CCDC 2061871: Experimental Crystal Structure Determination

description: Related Article: Christopher Marsh, Xue Han, Jiangnan Li, Zhenzhong Lu, Stephen P. Argent, Ivan da Silva, Yongqiang Cheng, Luke L. Daemen, Anibal J. Ramirez-Cuesta, Stephen P. Thompson, Alexander J. Blake, Sihai Yang, Martin Schröder|2021|J.Am.Chem.Soc.|143|6586|doi:10.1021/jacs.1c01749
DOI: 10.26036/cnp0000380
title: 噬菌体bgi-phage

description: 噬菌体是侵染细菌的一类病毒，被认为是细菌之间进行遗传信息交换的一大使者，它可整合入细菌基因组随其进行复制，也可最终导致细菌裂解死亡。本项目是针对噬菌体挖掘与合成方向的系统而全面的基础与应用研究，涉及以下三大研究点：1. 噬菌体的高通量挖掘流程的开发2. 噬菌体重编程及其在细菌调控上的应用3. 噬菌体疗法对抗细菌感染引起的相关疾病
DOI: 10.5517/ccdc.csd.cc1m1q6l
title: CCDC 1491199: Experimental Crystal Structure Determination

description: Related Article: Christopher Marsh, Xue Han, Jiangnan Li, Zhenzhong Lu, Stephen P. Argent, Ivan da Silva, Yongqiang Cheng, Luke L. Daemen, Anibal J. Ramirez-Cuesta, Stephen P. Thompson, Alexander J. Blake, Sihai Yang, Martin Schröder|2021|J.Am.Chem.Soc.|143|6586|doi:10.1021/jacs.1c01749
DOI: 10.26036/cnp0000387
title: stLFR Library Kit demo data

description: Whole genome sequencing will be the largest application direction and the largest market in the field of sequencing in the future.It is necessary to develop a genomic sequencing kit on BGISEQ/MGISEQ to further meet the advantages of low prices to achieve the purpose of occupying the market.Most conventional whole-genome sequencing products on the market ignore the diploid characteristics of the human genome, or some of the available methods are difficult to use widely for different reasons, such as the CPT-seq method requiring custom-made transposase linker sequences and specific Sequencing methods are difficult to implement in general laboratories.The stLFR technology is more advantageous as an upgrade of the original LFR technology. It does not require any automated pipetting equipment and does not require MDA amplification. The data quality is significantly better than the CPT-seq technology in the length of Phasing. The equipment is simpler to operate and lower in cost.
DOI: 10.5517/ccdc.csd.cc26wpqj
title: CCDC 2052408: Experimental Crystal Structure Determination

description: Related Article: Li Tan, Zhishan Luo, Xiaoyong Chang, Yi Wei, Min Tang, Wen Chen, Qian Li, Pengfei Shen, Zewei Quan|2021|Inorg.Chem.|60|6600|doi:10.1021/acs.inorgchem.1c00393