cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc25n4rr
title: CCDC 2015364: Experimental Crystal Structure Determination

description: Related Article: Qiaomu Yang, Yusen Qiao, Alex McSkimming, Liane M. Moreau, Thibault Cheisson, Corwin H. Booth, Ekaterina Lapsheva, Patrick J. Carroll, Eric J. Schelter|2021|Inorg.Chem.Front.|8|934|doi:10.1039/D0QI00969E
DOI: 10.5517/ccdc.csd.cc2688zr
title: CCDC 2033754: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc26890t
title: CCDC 2033755: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc26891v
title: CCDC 2033756: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc26892w
title: CCDC 2033757: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc26893x
title: CCDC 2033758: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc26894y
title: CCDC 2033759: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc26895z
title: CCDC 2033760: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc268960
title: CCDC 2033761: Experimental Crystal Structure Determination

description: Related Article: Julia Krzywik, Maral Aminpour, Jan Janczak, Ewa Maj, Mahshad Moshari, Witold Mozga, Joanna Wietrzyk, Jack.A. Tuszyński, Adam Huczyński|2021|Eur.J.Med.Chem.|215|113282|doi:10.1016/j.ejmech.2021.113282
DOI: 10.5517/ccdc.csd.cc267d84
title: CCDC 2032895: Experimental Crystal Structure Determination

description: Related Article: Guang-Qing Wang, Jie-Fen Huang, Xiao-Feng Huang, Shu-Qi Deng, Sheng-Run Zheng, Song-Liang Cai, Jun Fan, Wei-Guang Zhang|2021|Inorg.Chem.Front.|8|1083|doi:10.1039/D0QI01257B
DOI: 10.25505/fiz.icsd.cc273wy6
title: CSD 2059328: Experimental Crystal Structure Determination

description: Related Article: O. Isnard, S. Miraglia, D. Fruchart, J. Deportes|1992|J.Magn.Magn.Mater.|103|157|doi:10.1016/0304-8853(92)90249-N
DOI: 10.25505/fiz.icsd.cc277sz8
title: CSD 2063080: Experimental Crystal Structure Determination

description: Related Article: M. Reehuis, W. Jeitschko|1990|J.Phys.Chem.Solids|51|961|doi:10.1016/0022-3697(90)90039-I
DOI: 10.17033/data.00000142
title: The formulation of curcumin preparations with enhanced bioavailability for manufacturing in Vietnam

description: The climate and hill/mountain soil in Vietnam are suitable for the large scale cultivation of Curcuma longa, a crop which allows enhanced income and employment for local farmers. Curcumin, extracted from Curcuma Longa, is used in food, health and cosmetic products within Vietnam and for export; current production is estimated at circa 100 tons per year. Curcumin is also of increasing interest medically in terms of its anti-oxidant and anti-inflammatory activity, but a key issue is that its oral bioavailability is low. The aim of this work was to allow enhanced oral bioavailability from solid oral dosage forms that can be sustainably (economically and environmentally) manufactured in Vietnam, using local materials. The target set for this project, and achieved at its conclusion, was to develop at least one formulation, and to have started scale-up studies prior to full-scale production
description: This was a formulation development exercise completed in the Labs at the university of Brighton and Techbifarm, Hanoi.
DOI: 10.26126/intervals.tmvgi7
title: Aerosol generation [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Along the study, the aerosol was assessed in order to ensure robust delivery of the smoke or aerosols to the animal chambers. This monitoring included chamber aerosol delivery parameters, chemical characterization, and particle size distribution.
This dataset includes single measurements.
DOI: 10.26126/intervals.potpkb
title: Aerosol uptake and exposure [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Biomarkers of exposure, including carboxyhemoglobin, nicotine, nicotine metabolites, and biomarkers of exposure to HPHCs were measured in blood and in urine.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.b4ghhe
title: BALF flow cytometry [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Free lung cells (FLCs) in the bronchoalveolar lavage fluid were characterized and quantified by flow cytometry.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.nof6ba
title: BALF protein analysis [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
BALF was characterized using targeted proteomics.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.vmwfdt
title: Blood flow cytometry [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Blood cells were characterized and quantified by flow cytometry.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.mevewd
title: Clinical chemistry [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Clinical chemistry parameters to monitor kidney and liver function and metabolic profiles were assessed.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.d4q55u
title: General condition and health [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Along the study, general health of animals was monitored. This includes weekly body weight measurement, food and water intake, group and individual observations, ophthalmoscopy, and mortality.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.qtplkp
title: Hematology [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study where A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Platelets, red and white blood cells, as well as the clotting potential were measured in blood samples.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.b87fld
title: Histology - Lung tumor [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The incidence, multiplicity, load and size of lung tumors were determined by a histopathologist.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.owx32a
title: Histology - Non-respiratory [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Histopathological evaluation of the non-respiratory organs, including >100 organs or parts thereof, according to the OECD Test Guideline 453 for Combined Chronic Toxicity/Carcinogenicity Studies.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.cdj8hp
title: Histology - Respiratory tract [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Histopathological evaluation of the respiratory organs, including larynx, trachea, and lung, according to the OECD Test Guideline 453 for Combined Chronic Toxicity/Carcinogenicity Studies.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.gqp3cj
title: Larynx miRNA [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Because the most proximal part of the trachea was dissected together with the larynx, and further trimming and separation of the tissues was not desirable in favor of preserving nucleic acid integrity, laryngeal and tracheal epithelia were combined (termed “larynx” herein) for transcriptomics analysis.
The larynx miRNome was characterized using Affymetrix GeneChip™ miRNA 4.0 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8541.
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.a53xu7
title: Larynx miRNA [miRNA expression levels per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The trachea miRNome was characterized using Affymetrix GeneChip™ miRNA 4.0 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8541.
This dataset is the normalized intensity values for each miRNA and each sample.
DOI: 10.26126/intervals.q55sc8
title: Larynx mRNA [Gene expression levels per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Because the most proximal part of the trachea was dissected together with the larynx, and further trimming and separation of the tissues was not desirable in favor of preserving nucleic acid integrity, laryngeal and tracheal epithelia were combined (termed “larynx” herein) for transcriptomics analysis.
The trachea transcriptome was characterized using Affymetrix GeneChip® Mouse 430 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8540.
This dataset is the normalized intensity values for each gene and each sample.
DOI: 10.26126/intervals.vs3ys6
title: Larynx mRNA [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Because the most proximal part of the trachea was dissected together with the larynx, and further trimming and separation of the tissues was not desirable in favor of preserving nucleic acid integrity, laryngeal and tracheal epithelia were combined (termed “larynx” herein) for transcriptomics analysis.
The trachea transcriptome was characterized using Affymetrix GeneChip® Mouse 430 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8540.
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.qbc5fa
title: Lung emphysema [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The extent of emphysema was assessed by histomorphometry and lung volume measurements.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.7yxk37
title: Lung function [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Lung function measurements using unrestrained whole body plethysmography (FlexiVent system, SCIREQ, Montreal, Canada).
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.q6uwyh
title: Lung miRNA [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The lung miRNome was characterized using Affymetrix GeneChip™ miRNA 4.0 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8541. There is only data from the whole (left) lung for one time point (month 1).
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.w4ym2t
title: Lung miRNA [miRNA expression levels per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The lung miRNome was characterized using Affymetrix GeneChip™ miRNA 4.0 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8541. There is only data from the whole (left) lung for one time point (month 1).
This dataset is the normalized intensity values for each miRNA and each sample.
DOI: 10.26126/intervals.8tn6kk
title: Lung mRNA [Gene expression levels per animal] 

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The lung transcriptome was characterized using Affymetrix GeneChip® Mouse 430 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8540. Data are for both lung tumors and parenchyma (and not whole lung) for months 5, 10, and 15/18.
This dataset is the normalized intensity values for each gene and each sample.
DOI: 10.26126/intervals.aow6fu
title: Lung mRNA [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The lung transcriptome was characterized using Affymetrix GeneChip® Mouse 430 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8540. Data are for both lung tumors and parenchyma (and not whole lung) for months 5, 10, and 15/18.
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.i6gn46
title: Lung untargeted proteomics (iTRAQ) [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The lung proteome was characterized using iTRAQ (untargeted analysis). The full dataset is available in PRIDE under the accession number PXD016460. There is only data from the whole (left) lung for one time point (month 1).
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.24d6ls
title: Lung untargeted proteomics (iTRAQ) [Protein expression level per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The lung proteome was characterized using iTRAQ (untargeted analysis). The full dataset is available in PRIDE under the accession number PXD016460. There is only data from the whole (left) lung for one time point (month 1).
This dataset is the normalized intensity values for each identified protein and each sample.
DOI: 10.26126/intervals.zpubth
title: Nasal epithelium miRNA [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The nasal epithellium miRNome was characterized using Affymetrix GeneChip™ miRNA 4.0 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8541.
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.urjdme
title: Nasal epithelium miRNA [miRNA expression levels per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The nasal epithellium miRNome was characterized using Affymetrix GeneChip™ miRNA 4.0 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8541.
This dataset is the normalized intensity values for each miRNA and each sample.
DOI: 10.26126/intervals.3ohga6
title: Nasal epithelium mRNA [Gene expression levels per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The nasal epithelium transcriptome was characterized using Affymetrix GeneChip® Mouse 430 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8540.
This dataset is the normalized intensity values for each gene and each sample.
DOI: 10.26126/intervals.52l8fr
title: Nasal epithelium mRNA [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The nasal epithelium transcriptome was characterized using Affymetrix GeneChip® Mouse 430 Array. The full dataset is available from ArrayExpress under the identifier: E-MTAB-8540.
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.53um4n
title: Nasal epithelium untargeted proteomics (iTRAQ) [Inferential statistics]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The nasal epithelium proteome was characterized using iTRAQ (untargeted analysis). The full dataset is available in PRIDE under the accession number PXD016466.
This dataset contains the statistics resulting from the comparison of treatment and control groups.
DOI: 10.26126/intervals.224x6t
title: Nasal epithelium untargeted proteomics (iTRAQ) [Protein expression level per animal]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
The nasal epithelium proteome was characterized using iTRAQ (untargeted analysis). The full dataset is available in PRIDE under the accession number PXD016466.
This dataset is the normalized intensity values for each identified protein and each sample.
DOI: 10.26126/intervals.d26giv
title: Organ weight [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Gross pathology, including organ weight was assessed.
This dataset includes single measurements for each animal.
DOI: 10.26126/intervals.7d8lkg
title: Urinalysis and fecal corticosterone [Individual measurements]

description: This dataset was generated in an in vivo systems toxicology study during which A/J mice were exposed to cigarette smoke or aerosol of a heat-not-burn platform, THS 2.2, for up to 18 months (please refer to the study page for more detail on the study design).
Urinalysis and fecal corticosterone measurements were perfomed.
This dataset includes single measurements for each animal.