cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7338938.v1
title: Visual Abstract CKD Suriname

description: This is a visual abstract of the paper: "Chronic kidney disease and kidney health care status: the healthy lifein Suriname (HeliSur) study"<br>Nannan Panday R, Haan Y, Diemer F, Punwasi A, Rommy C, Heerenveen I, van Montfrans GA, Brewster LM.Intern Emerg Med. 2018 Oct 26. doi: 10.1007/s11739-018-1962-3.<br>AbstractThe high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a random sample of the adult population, we collected data with standardized questionnaires, physical examination, and blood and urine samples analysed in a central laboratory. Prevalent CKD was graded with KDIGO guidelines. In addition, we assessed national data on prevalent renal replacement therapy (RRT), estimated the future need for RRT, and evaluated national kidney health work force and policies.We include 1117 participants (2.0‰ of the population), 63% women, 40% of African ancestry and 43% of Asian ancestry,with a mean age of 42.2 (SE 0.4) years. Blood pressure is elevated in 72% of the participants, 26% have diabetes or prediabetes, and 78% are obese or overweight. The prevalence of CKD is 5.4%, and around 0.3% have kidney failure, translating to approximately 1500 patients nationally (2690 per million population, pmp), with currently 516 patients (920 pmp) on dialysis.Based on the participants from the random population sample in CKD stage G3 or G4, we estimate that 6750–10,750 pmp may develop kidney failure within the next 10 years. However, specialized kidney health workforce is currently very limited, and specific national or local policies for CKD management are lacking. Since the large majority of the general population has one or more risk factors for CKD including elevated blood pressure, urgent action is needed to strengthen kidney health care and prevent a catastrophic rise in need for RRT in the coming years.<br>Keywords Cardiovascular risk factors · Chronic kidney disease · Renal replacement therapy · Low- and middle-income countries · Kidney health care
DOI: 10.7284/101946
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1006 using a Furuno GP-90D instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101947
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1006 using a Ashtech ADU2 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101953
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1006 using a MX Marine MX421 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101948
title: Gravimeter data collected during research cruise RR1006 using a Bell BGM-3 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101949
title: Meteorological Station data collected during research cruise RR1006 using a SIO MET-System instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101954
title: Multibeam Echosounder data collected during research cruise RR1006 using a Kongsberg EM122 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101966
title: Singlebeam Echosounder data collected during research cruise RR1006 using a Knudsen 320B/R instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101945
title: Winch data collected during research cruise RR1006 using a Markey DUTW-9-11 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338893
title: Physical confinement alters sarcoma cell cycle progression and division

description: Tumor cells experience physical confinement on one or multiple axes, both in the primary tumor and at multiple stages during metastasis. Recent work has shown that confinement in a 3D spheroid alters nucleus geometry and delays cell division, and that vertical confinement impairs mitotic spindle rounding, resulting in abnormal division events. Meanwhile, the effects of bi-axial confinement on cell cycle progression has received little attention. Given the critical role of nuclear shape and mechanics in cell division, we hypothesized that bi-axial physical confinement of the cell body and nucleus would alter cell cycle progression. We used sarcoma cells stably expressing the fluorescence ubiquitination cell cycle indicator (FUCCI), along with fibronectin-coated microchannel devices, and explored the impact of bi-axial physical confinement on cell cycle progression. Our results demonstrate that bi-axial physical confinement reduces the frequency of cell division, which we found to be attributed to an arrest in the S/G2/M phase of the cell cycle, and increases the frequency of abnormal division events. Cell and nuclear morphology were both altered in confinement, with the most confining channels preventing cells from undergoing the normal increase in size from G1 to S/G2/M during cell cycle progression. Finally, our results suggest that confinement induces a mechanical memory to the cells, given our observation of lasting effects on cell division and morphology, even after cells exited confinement. Together, our results provide new insights into the possible impact of mechanical forces on primary and secondary tumor formation and growth.
DOI: 10.7284/102001
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise RR1007 using a Hawaii UHDAS instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338893.v2
title: Physical confinement alters sarcoma cell cycle progression and division

description: Tumor cells experience physical confinement on one or multiple axes, both in the primary tumor and at multiple stages during metastasis. Recent work has shown that confinement in a 3D spheroid alters nucleus geometry and delays cell division, and that vertical confinement impairs mitotic spindle rounding, resulting in abnormal division events. Meanwhile, the effects of bi-axial confinement on cell cycle progression has received little attention. Given the critical role of nuclear shape and mechanics in cell division, we hypothesized that bi-axial physical confinement of the cell body and nucleus would alter cell cycle progression. We used sarcoma cells stably expressing the fluorescence ubiquitination cell cycle indicator (FUCCI), along with fibronectin-coated microchannel devices, and explored the impact of bi-axial physical confinement on cell cycle progression. Our results demonstrate that bi-axial physical confinement reduces the frequency of cell division, which we found to be attributed to an arrest in the S/G2/M phase of the cell cycle, and increases the frequency of abnormal division events. Cell and nuclear morphology were both altered in confinement, with the most confining channels preventing cells from undergoing the normal increase in size from G1 to S/G2/M during cell cycle progression. Finally, our results suggest that confinement induces a mechanical memory to the cells, given our observation of lasting effects on cell division and morphology, even after cells exited confinement. Together, our results provide new insights into the possible impact of mechanical forces on primary and secondary tumor formation and growth.
DOI: 10.7284/101997
title: Expendable Probe data collected during research cruise RR1007 using a Sippican MK21 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338881
title: EQUA-S

description: Data from EQUA-S validation
DOI: 10.7284/101992
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1007 using a Furuno GP-90D instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338881.v2
title: EQUA-S

description: Data from EQUA-S validation
DOI: 10.7284/101993
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1007 using a Ashtech ADU2 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338881.v1
title: EQUA-S

description: Data from EQUA-S validation
DOI: 10.7284/101998
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1007 using a MX Marine MX421 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338854
title: Supplementary Material for: In-Hospital Mortality and Major Adverse Cardiovascular Events after Kidney Transplantation in the United States

description: <b><i>Background:</i></b> Kidney transplantation (KT) is the treatment of choice for end-stage kidney disease. Cardiovascular disease is a major determinant of morbidity and mortality in patients with KT. Temporal trends in perioperative cardiovascular outcomes after KT are understudied, especially in light of an aging KT waitlist population. <b><i>Methods:</i></b> We performed a retrospective observational cohort study using the National Inpatient Sample for the years 2004–2013. All adult patients undergoing KT were identified using the appropriate International Classification of Diseases, 9th Revision, Clinical Modification codes. Demographic and hospital characteristics, discharge disposition, payer status, and major adverse cardiovascular events (MACEs) were summarized using summary statistics. Multivariate logistic regression was used to identify predictors of MACEs in the perioperative period of KT. <b><i>Results:</i></b> A total of 147,431 KTs were performed between 2004 and 2013. The mean age at KT went up from 48.1 to 51.8 years from 2004 to 2013. Medicare was the primary payer for 59.6% of the KTs. Overall average perioperative mortality was 0.5%, median length of stay was 5 days, and 6.5% of patients experienced an MACE, 78% of which were heart failures (HFs). Important predictors of perioperative MACEs were age ≥65 years (OR = 2.14), Medicare as primary payer (OR = 1.51), diabetes (OR = 1.46), recreational drug use (OR = 1.72), pulmonary circulation disorders (OR = 3.28), and malnutrition (OR = 1.91). <b><i>Conclusion:</i></b> Despite increases in age at the time of KT, the absolute risk of perioperative MACEs has remained stable from 2004 to 2013. HF is a major component of postoperative MACEs in KT. Malnutrition and pulmonary hypertension are major nontraditional predictors of perioperative MACE outcomes.
DOI: 10.7284/101994
title: Gravimeter data collected during research cruise RR1007 using a Bell BGM-3 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/101995
title: Meteorological Station data collected during research cruise RR1007 using a SIO MET-System instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338836
title: Table of events from Probing layered arc crust in the Lesser Antilles using receiver functions

description: Details of the events used to create the stacked receiver functions.
DOI: 10.6084/m9.figshare.7338836.v1
title: Table of events from Probing layered arc crust in the Lesser Antilles using receiver functions

description: Details of the events used to create the stacked receiver functions.
DOI: 10.7284/101999
title: Multibeam Echosounder data collected during research cruise RR1007 using a Kongsberg EM122 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338824
title: Supplementary Material for: Rhabdomyolysis among Critically Ill Combat Casualties: Long-Term Outcomes

description: <b><i>Background:</i></b> Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (HTN), among service members initially admitted to the intensive care unit after sustaining a combat injury in Iraq or Afghanistan between February 1, 2002 and February 1, 2011. <b><i>Methods:</i></b> Information on age, sex, injury severity score, mechanism of injury, serum creatinine, burn injury, presenting mean arterial pressure, and creatine kinase were retrospectively collected and analyzed for 2,208 patients. Standard descriptive tests were used to compare characteristics of patients with and without rhabdomyolysis. Competing risk Cox proportional hazards models were performed to assess the associated risk of rhabdomyolysis with both HTN and poor renal function. <b><i>Results:</i></b> While rhabdomyolysis was associated with HTN on univariate analysis (hazard ratio [HR] 1.30, 95% CI 1.03–1.64; <i>p</i> = 0.029), this difference did not persist on multivariable analysis (HR 1.27, 95% CI 0.99–1.62; <i>p</i> = 0.058). The median estimated glomerular filtration rate (eGFR) was 119 (interquartile range [IQR] 103–128) among those with rhabdomyolysis, compared with 108 (IQR 94–121) in the group without rhabdomyolysis (<i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> After adjustment, patients with rhabdomyolysis were not at an increased risk of HTN compared to patients without rhabdomyolysis. eGFR was paradoxically higher in patients with rhabdomyolysis. There was no association found between rhabdomyolysis and mortality.
DOI: 10.7284/102000
title: Singlebeam Echosounder data collected during research cruise RR1007 using a Knudsen 320B/R instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338824.v1
title: Supplementary Material for: Rhabdomyolysis among Critically Ill Combat Casualties: Long-Term Outcomes

description: <b><i>Background:</i></b> Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (HTN), among service members initially admitted to the intensive care unit after sustaining a combat injury in Iraq or Afghanistan between February 1, 2002 and February 1, 2011. <b><i>Methods:</i></b> Information on age, sex, injury severity score, mechanism of injury, serum creatinine, burn injury, presenting mean arterial pressure, and creatine kinase were retrospectively collected and analyzed for 2,208 patients. Standard descriptive tests were used to compare characteristics of patients with and without rhabdomyolysis. Competing risk Cox proportional hazards models were performed to assess the associated risk of rhabdomyolysis with both HTN and poor renal function. <b><i>Results:</i></b> While rhabdomyolysis was associated with HTN on univariate analysis (hazard ratio [HR] 1.30, 95% CI 1.03–1.64; <i>p</i> = 0.029), this difference did not persist on multivariable analysis (HR 1.27, 95% CI 0.99–1.62; <i>p</i> = 0.058). The median estimated glomerular filtration rate (eGFR) was 119 (interquartile range [IQR] 103–128) among those with rhabdomyolysis, compared with 108 (IQR 94–121) in the group without rhabdomyolysis (<i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> After adjustment, patients with rhabdomyolysis were not at an increased risk of HTN compared to patients without rhabdomyolysis. eGFR was paradoxically higher in patients with rhabdomyolysis. There was no association found between rhabdomyolysis and mortality.
DOI: 10.7284/101991
title: Winch data collected during research cruise RR1007 using a Markey DUTW-9-11 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.22023/mdx.7338797
title: Museum of Domestic Design & Architecture Case Study for Figshare Fest London 2018

description: In 2017, the Museum of Domestic Design & Architecture began to use figshare as a repository for research data and outputs for its Katagami stencil project. This presentation explores this use, how it came about and how MoDA and its researchers found using figshare, with reflections on future considerations. This is a Figshare fest London 15th November 2018 presentation.
DOI: 10.22023/mdx.7338797.v1
title: Museum of Domestic Design & Architecture Case Study for Figshare Fest London 2018

description: In 2017, the Museum of Domestic Design & Architecture began to use figshare as a repository for research data and outputs for its Katagami stencil project. This presentation explores this use, how it came about and how MoDA and its researchers found using figshare, with reflections on future considerations. This is a Figshare fest London 15th November 2018 presentation.
DOI: 10.7284/102011
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise RR1008 using a Hawaii UHDAS instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102007
title: Expendable Probe data collected during research cruise RR1008 using a Sippican MK21 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338764
title: Lipidomics and Metabolomics NCB-D36852A Romani et al.

description: Cells in tissues constantly experience mechanical forces imposed by surrounding cells and the extracellular matrix (ECM). Cells probe their mechanical environment with mechanoreceptors and mechanosensitive protein complexes, which then regulate mechanotransduction signaling pathways to induce the appropriate biological response. However, how metabolism is modulated by the mechanical microenvironment has only started to be addressed. Here we identify accumulation of lipids and cholesterol as a general cellular response to mechanical signals delivered by cell-matrix adhesions. Our findings identify a general mechanosensitive mechanism centered on Golgi dynamics and SREBP by which the physical cell microenvironment regulates a key metabolic pathway. <b><br> </b> <b> </b><br>
DOI: 10.6084/m9.figshare.7338764.v1
title: Lipidomics and Metabolomics NCB-D36852A Romani et al.

description: Cells in tissues constantly experience mechanical forces imposed by surrounding cells and the extracellular matrix (ECM). Cells probe their mechanical environment with mechanoreceptors and mechanosensitive protein complexes, which then regulate mechanotransduction signaling pathways to induce the appropriate biological response. However, how metabolism is modulated by the mechanical microenvironment has only started to be addressed. Here we identify accumulation of lipids and cholesterol as a general cellular response to mechanical signals delivered by cell-matrix adhesions. Our findings identify a general mechanosensitive mechanism centered on Golgi dynamics and SREBP by which the physical cell microenvironment regulates a key metabolic pathway. <b><br> </b> <b> </b><br>
DOI: 10.7284/102003
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1008 using a Furuno GP-90D instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338680
title: Additional file 2 of Numerical analysis of intracellular amino acid profiles of breast cancer cells with K-Ras or PI3K mutation in response to kinase inhibitors

description: All data set used in the paper are included in this file. (XLSX 36 kb)
DOI: 10.7284/102004
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1008 using a Ashtech ADU2 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7338680.v1
title: Additional file 2 of Numerical analysis of intracellular amino acid profiles of breast cancer cells with K-Ras or PI3K mutation in response to kinase inhibitors

description: All data set used in the paper are included in this file. (XLSX 36 kb)
DOI: 10.7284/102008
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1008 using a MX Marine MX421 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102005
title: Gravimeter data collected during research cruise RR1008 using a Bell BGM-3 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102006
title: Meteorological Station data collected during research cruise RR1008 using a SIO MET-System instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102009
title: Multibeam Echosounder data collected during research cruise RR1008 using a Kongsberg EM122 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102010
title: Singlebeam Echosounder data collected during research cruise RR1008 using a Knudsen 320B/R instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102002
title: Winch data collected during research cruise RR1008 using a Markey DUTW-9-11 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102021
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise RR1009 using a Hawaii UHDAS instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102017
title: Expendable Probe data collected during research cruise RR1009 using a Sippican MK21 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102013
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1009 using a Furuno GP-90D instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102014
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1009 using a Ashtech ADU2 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/102018
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1009 using a MX Marine MX421 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition