DOI: 10.5061/dryad.n940b
title: Data from: The contrasting phylodynamics of human influenza B viruses

description: A complex interplay of viral, host and ecological factors shape the
 spatio-temporal incidence and evolution of human influenza viruses.
 Although considerable attention has been paid to influenza A viruses, a
 lack of equivalent data means that an integrated evolutionary and
 epidemiological framework has until now not been available for influenza B
 viruses, despite their significant disease burden. Through the analysis of
 over 900 full genomes from an epidemiological collection of more than
 26,000 strains from Australia and New Zealand, we reveal fundamental
 differences in the phylodynamics of the two co-circulating lineages of
 influenza B virus (Victoria and Yamagata), showing that their individual
 dynamics are determined by a complex relationship between virus
 transmission, age of infection and receptor binding preference. In sum,
 this work identifies new factors that are important determinants of
 influenza B evolution and epidemiology.
description: Influenza B virus
 sequences from Australia and New Zealand, 2002–2013Tab delimited text file
 for 908 newly generated influenza B virus samples isolated from humans in
 Australia and New Zealand during 2002–2013. For each of these samples,
 virus sample name, collection data, country and GenBank accession numbers
 of each gene segment are provided.908_virus_accession.txtPrevalence percentageTab delimited text file providing percentages of viruses that were of type B in Australia (aus) and New Zealand (nz) and the three eastern states of Australia, New South Wales (nsw), Queensland (qld) and Victoria (vic). The percentage of viruses that were of Yamagata and Victoria lineages among all influenza B virus positive samples are provided for Australia (aus_yamagata and aus_victoria) and New Zealand (nz_yamagata and nz_victoria).Fig2_percentrage_prevalence.txtVirus accession numbersTab delimited text file for 908 newly generated influenza B virus samples isolated from humans in Australia and New Zealand during 2002–2013. For each of these samples, virus sample name, collection data, country and GenBank or GISAID accession numbers of each gene segment are provided.Virus_accession_numbers.txtBEAST xml file - B/VictoriaBeast input file (xml) with data and parameters used for Bayesian phylogenetic analysis of the HA dataset of B/Victoria viruses isolated in Australia and New Zealand.B_Victoria.xmlBEAST xml file - B/YamagataBeast input file (xml) with data and parameters used for Bayesian phylogenetic analysis of the HA dataset of B/Yamagata viruses isolated in Australia and New Zealand.B_Yamagata.xmlCases positive for influenza B virusesTab delimited text file providing patient age, country, date of sampling and lineage (Victoria or Yamagata) of 5260 influenza B viruses collected in Australia and New Zealand, 2002–2013cases.tsvHemagglutination inhibition titersExcel file with two sheets proving raw HI titer values for representative influenza B virus antigens of Victoria and Yamagata viruses isolated in Australia and New Zealand during 2002–2013 estimated against representative antisera. Strain names and passage history are provided for each antigen and antisera.HI_titers.xlsxPhylodynamic analysisBeast input file (xml) with data and parameters used to estimate epidemiological parameters (the effective reproductive number, Re) for each epidemic of virus lineages in Australia and New Zealand using the Birth-Death susceptible-infected-removed (BDSIR) model.BDSIR_analyses.zipPhylogeographic analysisBeast input file (xml) with data and parameters used to estimate counts of migration to and from Australia and New Zealand using the CTMC model.CTMC analyses.zip