cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2765g9k
title: BindingDB Entry 50039281: Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), 5-Hydroxytryptamine receptor 7 (5-HT7), 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 4 (5-HT4), Acetylcholinesterase, Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A3, Adrenergic alpha1B, Alpha-1A adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Amine oxidase [flavin-containing] A, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor and beta-3 adrenergic receptor, Cannabinoid receptor 1, Cholecystokinin receptor, Dopamine D1 and D2 receptor, Dopamine receptor, Dopamine receptor D2L/neurotensin receptor NTS1, EDNRA, Glucocorticoid receptor, High-affinity choline transporter, Histamine H1 receptor, Histamine H2 receptor, Histamine receptor (H3), Imidazoline receptor 1 (I1R), Kappa-type opioid receptor, Melanocortin receptor 4, Melatonin receptor, Mitogen-activated protein kinase 14, Mu-type opioid receptor, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M1/M5 chimeric protein, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M2 and M4, Neurokinin 1 receptor, Neurokinin 2 receptor, Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit, Neuropeptide Y receptor type 1, Ribosyldihydronicotinamide dehydrogenase [quinone], SRC, Serotonin 3 (5-HT3) receptor, Serotonin and norepinephrine transporters (SERT/NET), Serotonin receptor (2b and 2c), Sodium-dependent dopamine transporter, and Sodium-dependent noradrenaline transporter, Uniprot P04150, P07550, P07948, P08172, P08173, P08588, P08908, P08912, P08913, P0DMS8, P11229, P14416, P16083, P17787, P18089, P20309, P21397, P21452, P21554, P21728, P22303, P23975, P25021, P25100, P25101, P25103, P25929, P28222, P28223, P28335, P29274, P30542, P30989, P31645, P32239, P32245, P34969, P35348, P35367, P35368, P35372, P35462, P41145, P41595, P43681, P46098, P48039, Q01959, Q13639, Q16539, Q9GZV3, Q9Y2I1, and Q9Y5N1
DOI: 10.7270/q28p61d2
title: BindingDB Entry 50038351: Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone.

description: Small molecule binding data for protein 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Uniprot P09610
DOI: 10.7270/q29z95w6
title: BindingDB Entry 50039288: Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.

description: Small molecule binding data for protein Epidermal growth factor receptor, Platelet-derived growth factor receptor beta, and Vascular endothelial growth factor receptor 2, Uniprot P00533, P09619, and P35968
DOI: 10.7270/q2bz6710
title: BindingDB Entry 50039280: Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.

description: Small molecule binding data for protein DNA topoisomerase I (Topo I), Uniprot P11387
DOI: 10.7270/q2df6s2h
title: BindingDB Entry 50038350: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

description: Small molecule binding data for protein Sterol 14α-demethylase (CYP51), Uniprot Q16850
DOI: 10.7270/q2fq9xmj
title: BindingDB Entry 50039287: 1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors.

description: Small molecule binding data for protein Galectin-3, Galectin-7, Galectin-8, and Galectin-9, Uniprot O00182, O00214, P17931, and P47929
DOI: 10.7270/q2h70gpf
title: BindingDB Entry 50038357: 2D QSAR and similarity studies on cruzain inhibitors aimed at improving selectivity over cathepsin L.

description: Small molecule binding data for protein Cruzipain, Uniprot P25779
DOI: 10.7270/q2kh0p9c
title: BindingDB Entry 50039286: An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

description: Small molecule binding data for protein Macrophage migration inhibitory factor (MIF), Uniprot P14174
DOI: 10.7270/q2mc914m
title: BindingDB Entry 50040303: A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.

description: Small molecule binding data for protein Asparagine synthetase, Uniprot P08243
DOI: 10.7270/q2q52qmc
title: BindingDB Entry 50039285: Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening.

description: Small molecule binding data for protein Protein-tyrosine phosphatase alpha and Receptor-type tyrosine-protein phosphatase beta (PTPβ), Uniprot P18433 and P23467
DOI: 10.7270/q2r49rw0
title: BindingDB Entry 50040302: 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

description: Small molecule binding data for protein DNA topoisomerase type IB small subunit
DOI: 10.7270/q2rr2034
title: BindingDB Entry 50038355: Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents.

description: Small molecule binding data for protein Thyroid Hormone Receptor (TR-beta) and Thyroid hormone receptor, Uniprot F1D8N7, P10827, and P10828
DOI: 10.7270/q2sq918d
title: BindingDB Entry 50038347: Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88.

description: Small molecule binding data for protein Heparanase, Uniprot Q9Y251
DOI: 10.7270/q2tx3gbs
title: BindingDB Entry 50039284: Selectivity and potency of cyclin-dependent kinase inhibitors.

description: Small molecule binding data for protein CDK2/Cyclin A/Cyclin A1, Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3, Cyclin-A2, Cyclin-Dependent Kinase 5 (CDK5), Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, and Cyclin-dependent kinase 6, Uniprot O95067, P06493, P11802, P14635, P20248, P24941, P78396, Q00534, Q00535, and Q8WWL7
DOI: 10.7270/q2vx0hnd
title: BindingDB Entry 50040301: Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.

description: Small molecule binding data for protein Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), Uniprot P00492
DOI: 10.7270/q2wh2qvh
title: BindingDB Entry 50038354: Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.

description: Small molecule binding data for protein AKT/p21CIP1, C-RAF, Casein Kinase II, Cytochrome P450 3A, Dual specificity mitogen-activated protein kinase kinase 1, Epidermal growth factor receptor, Fibroblast growth factor receptor 3, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 10, Platelet-derived growth factor receptor beta, Protein kinase C alpha type, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), Rho-associated protein kinase, Ribosomal protein S6 kinase (P70S6K), SRC, Serine/threonine-protein kinase Aurora, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, and Vascular endothelial growth factor receptor 2, Uniprot O14920, O14965, O75116, P00519, P00533, P04049, P06213, P06239, P06241, P07332, P08069, P08684, P09619, P12931, P17252, P22607, P23443, P31749, P35968, P36888, P49137, P53779, P68400, Q02750, Q05397, and Q15118
DOI: 10.7270/q2zp472h
title: BindingDB Entry 50039283: Studies on ligand binding to histidine triad nucleotide binding protein 1.

description: Small molecule binding data for protein Protein kinase C-interacting protein 1, Uniprot P62959
DOI: 10.7270/q208665c
title: BindingDB Entry 50038361: Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.

description: Small molecule binding data for protein Cannabinoid receptor 1, Cannabinoid receptor 2, and Cannabinoid receptor 2 (CB2), Uniprot P21554, P34972, and Q9QZN9
DOI: 10.7270/q21g0n86
title: BindingDB Entry 50039298: Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies.

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B, Uniprot P21397 and P27338
DOI: 10.7270/q22f7pd1
title: BindingDB Entry 50039290: Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B, Uniprot P21397 and P27338
DOI: 10.7270/q2416xxr
title: BindingDB Entry 50038360: Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety.

description: Small molecule binding data for protein Delta-type opioid receptor, Kappa-type opioid receptor, and Mu-type opioid receptor, Uniprot P35372, P41143, and P41145
DOI: 10.7270/q2571d0x
title: BindingDB Entry 50039297: Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics.

description: Small molecule binding data for protein Glucocorticoid receptor, Mineralocorticoid receptor (MR), and Progesterone receptor, Uniprot P04150, P06401, and P08235
DOI: 10.7270/q2765gdx
title: BindingDB Entry 50040306: Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists.

description: Small molecule binding data for protein Metabotropic glutamate receptor 5, Uniprot P41594
DOI: 10.7270/q27s7pmq
title: BindingDB Entry 50038359: Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.

description: Small molecule binding data for protein Acetylcholinesterase and Histamine receptor (H3), Uniprot P22303 and Q9Y5N1
DOI: 10.7270/q29024s4
title: BindingDB Entry 50039296: Rose Bengal analogs and vesicular glutamate transporters (VGLUTs).

description: Small molecule binding data for protein Vesicular acetylcholine transporter, Uniprot Q62666
DOI: 10.7270/q2bk1d72
title: BindingDB Entry 50038366: Exploring the potential of 3'-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin.

description: Small molecule binding data for protein RNAse A, Uniprot P07998
DOI: 10.7270/q2bv7hr2
title: BindingDB Entry 50040305: JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.

description: Small molecule binding data for protein Cannabinoid receptor 1 and Cannabinoid receptor 2, Uniprot P21554 and P34972
DOI: 10.7270/q2cf9r01
title: BindingDB Entry 50038358: Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade.

description: Small molecule binding data for protein Epidermal growth factor receptor, PKC alpha and beta-2, SRC, Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, VEGF-receptor 2 and tyrosine-protein kinase SRC, and Vascular endothelial growth factor receptor 2, Uniprot P00533, P05771, P06239, P12931, P35968, P43403, and P43405
DOI: 10.7270/q2dr2wh5
title: BindingDB Entry 50039295: Development of chemical probes: toward the mode of action of a methylene-linked di(aryl acetate) E1.

description: Small molecule binding data for protein AKT/p21CIP1, Uniprot P31749
DOI: 10.7270/q2gm88dw
title: BindingDB Entry 50040304: Camptothecins in tumor homing via an RGD sequence mimetic.

description: Small molecule binding data for protein Integrin beta-3/Vitronectin receptor alpha and Integrin beta-5/Vitronectin receptor alpha, Uniprot P05106, P06756, and P18084
DOI: 10.7270/q2jh3n6f
title: BindingDB Entry 50039294: 2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.

description: Small molecule binding data for protein Adenosine receptor A1 and Estradiol receptor alpha (ERα), Uniprot P03372 and P25099
DOI: 10.7270/q2m04697
title: BindingDB Entry 50038364: Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).

description: Small molecule binding data for protein Voltage-gated potassium channel, Uniprot P22459 and Q09470
DOI: 10.7270/q2n017cq
title: BindingDB Entry 50038356: Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, Serotonin and norepinephrine transporters (SERT/NET), Sigma-1 receptor, and Voltage-gated potassium channel, Uniprot P08908, P31645, Q12809, and Q60492
DOI: 10.7270/q2p84cw9
title: BindingDB Entry 50039293: Evaluation of N-substitution in 6,7-benzomorphan compounds.

description: Small molecule binding data for protein Delta-type opioid receptor, Mu-type opioid receptor, Nociceptin/mu opioid receptor, Opioid receptors; mu & delta, and mu/kappa opioid receptor, Uniprot P33533, P33535, P35372, P41143, and P41144
DOI: 10.7270/q2qr4xzz
title: BindingDB Entry 50038363: Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors.

description: Small molecule binding data for protein Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1), Uniprot P62813
DOI: 10.7270/q2t154m1
title: BindingDB Entry 50039292: Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.

description: Small molecule binding data for protein Carbonic anhydrase, Carbonic anhydrase 2, Carbonic anhydrase 9, and Dihydrofolate reductase, Uniprot P00381, P00915, P00918, and Q16790
DOI: 10.7270/q2xp75xq
title: BindingDB Entry 50039291: Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.

description: Small molecule binding data for protein Acetylcholinesterase, Nociceptin/mu opioid receptor, Opioid receptors; mu & delta, and mu/kappa opioid receptor, Uniprot O42275, P33533, P33535, and P41144
DOI: 10.7270/q20k29j4
title: BindingDB Entry 50039306: Novel selective anti-androgens with a diphenylpentane skeleton.

description: Small molecule binding data for protein Androgen Receptor and Vitamin D receptor, Uniprot P10275, P11473, and P19091
DOI: 10.7270/q2319wsc
title: BindingDB Entry 50038368: Probing lipid- and drug-binding domains with fluorescent dyes.

description: Small molecule binding data for protein Non-specific lipid-transfer protein and Serum albumin, Uniprot P02769 and P22307
DOI: 10.7270/q23f4qr3
title: BindingDB Entry 50040307: Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.

description: Small molecule binding data for protein Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and Metabotropic glutamate receptor 5, Uniprot P08684, P10635, and P41594
DOI: 10.7270/q2474bv4
title: BindingDB Entry 50039305: 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety.

description: Small molecule binding data for protein Motilin receptor, Uniprot O43193
DOI: 10.7270/q26t0njs
title: BindingDB Entry 50038367: A photoswitchable ITAM peptidomimetic: synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis-trans isomerization on binding.

description: Small molecule binding data for protein Tyrosine-protein kinase SYK, Uniprot P43405
DOI: 10.7270/q28053kv
title: BindingDB Entry 50039304: Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.

description: Small molecule binding data for protein Acetylcholinesterase, Uniprot O42275
DOI: 10.7270/q2cr5vbb
title: BindingDB Entry 50039303: Factor Xa inhibitors: next-generation antithrombotic agents.

description: Small molecule binding data for protein Coagulation factor X, Coagulation factor X/antithrombin III, Prothrombin, and Voltage-gated potassium channel, Uniprot P00734, P00742, P00743, P01008, and Q12809
DOI: 10.7270/q2fb53t0
title: BindingDB Entry 50038373: Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.

description: Small molecule binding data for protein Glycogen debranching enzyme and alpha-Glucosidase (α-Glucosidase), Uniprot P23739 and P35573
DOI: 10.7270/q2fn179h
title: BindingDB Entry 50040312: Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kß inhibitors.

description: Small molecule binding data for protein Cytochrome P450 3A, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, PI3-kinase subunit gamma, and Serine/threonine-protein kinase mTOR, Uniprot O00329, P08684, P42336, P42338, P42345, and P48736
DOI: 10.7270/q2g73fmz
title: BindingDB Entry 50038365: 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.

description: Small molecule binding data for protein Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A2b, and Adenosine receptor A3, Uniprot P0DMS8, P29274, P29275, and P30542
DOI: 10.7270/q2hh6m22
title: BindingDB Entry 50039302: Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation.

description: Small molecule binding data for protein Acetylcholinesterase, Uniprot O42275
DOI: 10.7270/q2k35vhw
title: BindingDB Entry 50038372: A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.

description: Small molecule binding data for protein Adenosine receptor A1, Adenosine receptor A2a, and Adenosine receptor A3, Uniprot P0DMS8, P29274, and P30542
DOI: 10.7270/q2n87bsc
title: BindingDB Entry 50039301: Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors.

description: Small molecule binding data for protein Tyrosinase, Uniprot O42713
DOI: 10.7270/q2pr7wwg
title: BindingDB Entry 50038371: Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.

description: Small molecule binding data for protein Dopamine Transporter (DAT), Norepinephrine Monoamine transporters, and Sodium-dependent serotonin transporter, Uniprot P23977 and P31652
DOI: 10.7270/q2s183gn
title: BindingDB Entry 50039300: 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists.

description: Small molecule binding data for protein Motilin receptor
DOI: 10.7270/q2th8nkr
title: BindingDB Entry 50038370: Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), and Serotonin receptor (2b and 2c), Uniprot P28223, P28335, and P41595
DOI: 10.7270/q2tx3ggk
title: BindingDB Entry 50040309: Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry.

description: Small molecule binding data for protein Sodium channel protein type VIII alpha subunit, Uniprot O88420
DOI: 10.7270/q2vh5ppp
title: BindingDB Entry 50038362: Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.

description: Small molecule binding data for protein Prostaglandin G/H synthase (Cyclooxygenase-2) and Prostaglandin G/H synthase (cyclooxygenase), Uniprot P05979 and P79208
DOI: 10.7270/q2ws8v6p
title: BindingDB Entry 50039299: Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1B, Adrenergic alpha1B, Delta-type opioid receptor, Kappa-type opioid receptor, Peripheral-Type Benzodiazepine Receptor, and Serotonin receptor (2b and 2c), Uniprot P16257, P28222, P35368, P41143, P41145, and P41595
DOI: 10.7270/q2z89d9g
title: BindingDB Entry 50038369: 11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists.

description: Small molecule binding data for protein Progesterone receptor, Uniprot P06401
DOI: 10.7270/q2zp477r
title: BindingDB Entry 50040308: Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides.

description: Small molecule binding data for protein G-protein Coupled Receptor 54 and KiSS-1 receptor, Uniprot Q924U1 and Q969F8
DOI: 10.7270/q2222vnj
title: BindingDB Entry 50038376: Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.

description: Small molecule binding data for protein Bile acid receptor FXR and G-protein coupled bile acid receptor 1, Uniprot Q8TDU6 and Q96RI1
DOI: 10.15156/bio/sh2101411.08fu
title: SH2101411.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh2101412.08fu
title: SH2101412.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.