cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.57760/sciencedb.26173
title: The solar UV irradiance
title: The solar UV irradiance

description: The UV irradiance data were measured by the solar UV detector of the Space Radiobiological Exposure Facility on the China Space Station
description: The UV irradiance data were measured by the solar UV detector of the Space Radiobiological Exposure Facility on the China Space Station
DOI: 10.15468/dl.dnx7gn
title: Occurrence Download

description: A dataset listing the 138 species recorded in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry MULTIPOLYGON (((-67.26892 48.89052, -67.27431 48.89875, -67.27412 48.90153, -67.28656 48.9077, -67.29786 48.89997, -67.29989 48.89681, -67.29354 48.89238, -67.28631 48.89064, -67.28727 48.88731, -67.28523 48.88395, -67.29005 48.8815, -67.28579 48.87923, -67.2917 48.87342, -67.29495 48.86158, -67.29511 48.84866, -67.29233 48.84666, -67.29384 48.8439, -67.28924 48.8382, -67.28402 48.83903, -67.27864 48.83572, -67.28072 48.82806, -67.28251 48.82401, -67.27727 48.81864, -67.27418 48.82051, -67.2721 48.82566, -67.26311 48.82956, -67.26132 48.83274, -67.25986 48.83657, -67.26136 48.84054, -67.25358 48.85295, -67.24756 48.85908, -67.24719 48.86608, -67.24484 48.86892, -67.24605 48.87335, -67.2471 48.87676, -67.24603 48.8774, -67.252 48.87852, -67.25741 48.88383, -67.25969 48.88671, -67.2599 48.89056, -67.26892 48.89052)))"
 ]
}

 The dataset's 138 records were derived from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037621-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25442/hku.29209553
title: Supporting data for "Modelling the drug response of on patient-derived organoids to identify combinatorial therapies for diffuse-type gastric cancer"

description: The study used patient-derived organoids (PDOs) established from patients with gastric cancer to perform drug response characterization and combinatorial drug screens, aiming to dissect drug mechanism, and enhance treatment efficacy by identification of combinatorial drug partners. For data sourced from previous literature and available publicly, the raw datafiles are included for reference. For drug response characterization, drug mechanism was dissected through comprehensive analysis of gene expression changes at both bulk and single cell levels. Bulk RNAseq and single cell RNAseq were performed in parallel, with 3 treatment conditions on 8 PDOs. The dataset files include the Log2TPM value of the 24 bulk RNAseq samples, and the count matrix for each of the 24 single cell RNAseq samples. For combinatorial drug screening, the combinatorial synergy was evaluated for 24 drug combinations. For 10 of these combinations, the combinatorial synergy was evaluated on 15 PDOs. Each drug was tested in a serial dilution of 7 concentrations, and each two-drug combination was tested with a matrix of 49 conditions (7 x 7) in technical triplicates. The dataset files include the growth rate response of every treatment conditions of all the combinatorial drug screening experiments. In addition, for 2 of the drug combinations, downstream mechanistic analysis was performed using staining and western blot, and the dataset files include the staining results in terms of positive cell proportion, and raw photo of the chemiluminescent signal detection of every western blot. <br>
DOI: 10.25442/hku.29209553.v1
title: Supporting data for "Modelling the drug response of on patient-derived organoids to identify combinatorial therapies for diffuse-type gastric cancer"

description: The study used patient-derived organoids (PDOs) established from patients with gastric cancer to perform drug response characterization and combinatorial drug screens, aiming to dissect drug mechanism, and enhance treatment efficacy by identification of combinatorial drug partners. For data sourced from previous literature and available publicly, the raw datafiles are included for reference. For drug response characterization, drug mechanism was dissected through comprehensive analysis of gene expression changes at both bulk and single cell levels. Bulk RNAseq and single cell RNAseq were performed in parallel, with 3 treatment conditions on 8 PDOs. The dataset files include the Log2TPM value of the 24 bulk RNAseq samples, and the count matrix for each of the 24 single cell RNAseq samples. For combinatorial drug screening, the combinatorial synergy was evaluated for 24 drug combinations. For 10 of these combinations, the combinatorial synergy was evaluated on 15 PDOs. Each drug was tested in a serial dilution of 7 concentrations, and each two-drug combination was tested with a matrix of 49 conditions (7 x 7) in technical triplicates. The dataset files include the growth rate response of every treatment conditions of all the combinatorial drug screening experiments. In addition, for 2 of the drug combinations, downstream mechanistic analysis was performed using staining and western blot, and the dataset files include the staining results in terms of positive cell proportion, and raw photo of the chemiluminescent signal detection of every western blot. <br>
DOI: 10.15468/dl.65x8xe
title: Occurrence Download

description: A dataset containing 66664 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rhinogobius Gill, 1859"
 ]
}

 The dataset includes 66664 records from 157 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037622-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29299286
title: rmsd_matrix_for_clustering

description: frame-frame RMSD calculated from the production runs
DOI: 10.6084/m9.figshare.29299286.v1
title: rmsd_matrix_for_clustering

description: frame-frame RMSD calculated from the production runs
DOI: 10.25442/hku.29211380
title: Supporting data for ""Genipin-Mediated Suppression of Inflammatory Macrophage Influx Reduces Postoperative Recurrence in Hepatocellular Carcinoma"

description: Surgical resection is the primary treatment regimen for early- to intermediate-stage hepatocellular carcinoma (HCC). However, postoperative recurrence affects up to 70% of patients within five years after surgery, significantly impairing postoperative patient prognosis. To date, no systemic therapeutics have been approved to prevent HCC recurrence, highlighting the urgent need to develop effective adjuvant postoperative interventions. The postoperative tumor microenvironment (TME), enriched with growth factors and inflammatory cytokines from liver regeneration and inflammation, facilitates residual tumor cell growth. Macrophages within the TME play a critical role in promoting tumor recurrence through angiogenesis and immunosuppression, with increased infiltration associated with higher recurrence risks. In this study, we investigated genipin, a compound derived from Gardenia jasminoides used in traditional Chinese medicine, as a novel therapeutic agent to suppress HCC recurrence by targeting postoperative macrophage influx.An orthotopic mouse model of HCC recurrence was developed to replicate human postoperative HCC conditions, involving orthotopic tumor implantation followed by surgical resection. Genipin, administered orally at 25 mg/kg and 50 mg/kg, dose-dependently delayed postoperative recurrence and reduced tumor burden, Genipin exhibited minimal cytotoxicity against HCC cells in vitro, suggesting its effects are mediated through TME modulation rather than direct tumor cell killing. Specifically, genipin significantly reduced the infiltration of pro-inflammatory CD11b+F4/80+Ly6C+ macrophages into the postoperative liver by interfering with CCL2/CCR2 mediated macrophage migration. While postoperative adoptive transfer of macrophages accelerated tumor recurrence and abolished the therapeutic effects of genipin.Mechanistically, genipin was identified as a natural PPARγ agonist. By activating PPARγ, genipin suppressed NF-κB p65-driven transcriptional programs that govern both CCR2 expression on macrophages and CCL2 secretion by hepatocytes. Through dual downregulation on the chemokine ligand production and receptor expression, genipin achieved robust inhibition of CCL2/CCR2 chemotaxis-mediated macrophage infiltration into the postoperative liver microenvironment and thereby inhibited HCC recurrence.Finally, multiplex immunohistochemistry analysis on HCC human samples revealed that macrophage infiltration in the adjacent liver combined with vascular integrity of primary HCC could effectively stratify patients with higher recurrence risks. We highlight the adjacent liver tissue derived biomarkers with superior predictive efficacy for postoperative recurrence, underscoring their capacity in reflecting the postoperative microenvironment that harbors residual HCC cells.<br>
DOI: 10.25442/hku.29211380.v1
title: Supporting data for ""Genipin-Mediated Suppression of Inflammatory Macrophage Influx Reduces Postoperative Recurrence in Hepatocellular Carcinoma"

description: Surgical resection is the primary treatment regimen for early- to intermediate-stage hepatocellular carcinoma (HCC). However, postoperative recurrence affects up to 70% of patients within five years after surgery, significantly impairing postoperative patient prognosis. To date, no systemic therapeutics have been approved to prevent HCC recurrence, highlighting the urgent need to develop effective adjuvant postoperative interventions. The postoperative tumor microenvironment (TME), enriched with growth factors and inflammatory cytokines from liver regeneration and inflammation, facilitates residual tumor cell growth. Macrophages within the TME play a critical role in promoting tumor recurrence through angiogenesis and immunosuppression, with increased infiltration associated with higher recurrence risks. In this study, we investigated genipin, a compound derived from Gardenia jasminoides used in traditional Chinese medicine, as a novel therapeutic agent to suppress HCC recurrence by targeting postoperative macrophage influx.An orthotopic mouse model of HCC recurrence was developed to replicate human postoperative HCC conditions, involving orthotopic tumor implantation followed by surgical resection. Genipin, administered orally at 25 mg/kg and 50 mg/kg, dose-dependently delayed postoperative recurrence and reduced tumor burden, Genipin exhibited minimal cytotoxicity against HCC cells in vitro, suggesting its effects are mediated through TME modulation rather than direct tumor cell killing. Specifically, genipin significantly reduced the infiltration of pro-inflammatory CD11b+F4/80+Ly6C+ macrophages into the postoperative liver by interfering with CCL2/CCR2 mediated macrophage migration. While postoperative adoptive transfer of macrophages accelerated tumor recurrence and abolished the therapeutic effects of genipin.Mechanistically, genipin was identified as a natural PPARγ agonist. By activating PPARγ, genipin suppressed NF-κB p65-driven transcriptional programs that govern both CCR2 expression on macrophages and CCL2 secretion by hepatocytes. Through dual downregulation on the chemokine ligand production and receptor expression, genipin achieved robust inhibition of CCL2/CCR2 chemotaxis-mediated macrophage infiltration into the postoperative liver microenvironment and thereby inhibited HCC recurrence.Finally, multiplex immunohistochemistry analysis on HCC human samples revealed that macrophage infiltration in the adjacent liver combined with vascular integrity of primary HCC could effectively stratify patients with higher recurrence risks. We highlight the adjacent liver tissue derived biomarkers with superior predictive efficacy for postoperative recurrence, underscoring their capacity in reflecting the postoperative microenvironment that harbors residual HCC cells.<br>
DOI: 10.15468/dl.m38asr
title: Occurrence Download

description: A dataset containing 624080 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Country is one of (Canada, Mexico, United States of America)",
 "EventDate is greater than or equal to 2025-05-17",
 "EventDate is less than or equal to 2025-06-16",
 {
 "not" : {
 "Issue" : [
 "is one of (Basis of record invalid, Coordinate reprojection failed, Coordinate reprojection suspicious, Coordinate precision invalid, Coordinate uncertainty meters invalid, Country mismatch, Country invalid, Geodetic datum invalid, Presumed swapped coordinate, Presumed negated longitude, Presumed negated latitude, Country coordinate mismatch)"
 ]
 }
 }
 ]
}

 The dataset includes 624080 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037623-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29279675
title: <b>Transcriptomics analysis and cold resistance in </b><b><i>Paeonia veitchii</i></b>

description: <i>Paeonia veitchii </i>is an important economic plant that is known for its exceptional medicinal value and for its remarkable tolerance to cold.<i> </i>However, the molecular mechanisms underlying its cold tolerance remain unclear. In this study, an integrated approach combining physiological analysis and multi-omics techniques was employed to investigate the metabolic pathways and molecular mechanisms involved in the cold stress response of<i> P. veitchii</i>. Metabolomic analysis revealed significant changes in the levels of 61 metabolites under cold stress, with prominent increases in polyamines (e.g., p-Coumaroylputrescine, +2.97-fold) and phenolic acids (e.g., Syringic acid, +3.69-fold). Transcriptomic profiling identified 22,525 DEGs, including 3,852 genes enriched in cold adaptation pathways including plant hormone signaling, MAPK signaling and glutathione metabolism. Key regulators of polyamine and phenolic acid metabolism were identified, including aldehyde dehydrogenase, arginine decarboxylase, polyamine oxidase (<i>PAO</i>), S-adenosylmethionine decarboxylase and aspartate aminotransferase, with downregulation of <i>PAO</i> promoting salidroside accumulation but simultaneously suppressing methylated indole-3-acetic acid. Moreover, the reduced accumulation of flavonoids may be linked to the expression of flavonoid 3'-monooxygenase. Furthermore, it was discovered that the ETH, JA-lle, SA, and MAPK signaling pathways play an active role in the signaling of <i>P. veitchii</i> roots during the response to cold stress. This study offers valuable insights into the complex regulatory mechanisms that govern the cold stress response in <i>P. veitchii</i> roots, thereby establishing a theoretical basis for a more comprehensive comprehension of its response and adaptation mechanisms to cold stress.
DOI: 10.6084/m9.figshare.29279675.v2
title: <b>Transcriptomics analysis and cold resistance in </b><b><i>Paeonia veitchii</i></b>

description: <i>Paeonia veitchii </i>is an important economic plant that is known for its exceptional medicinal value and for its remarkable tolerance to cold.<i> </i>However, the molecular mechanisms underlying its cold tolerance remain unclear. In this study, an integrated approach combining physiological analysis and multi-omics techniques was employed to investigate the metabolic pathways and molecular mechanisms involved in the cold stress response of<i> P. veitchii</i>. Metabolomic analysis revealed significant changes in the levels of 61 metabolites under cold stress, with prominent increases in polyamines (e.g., p-Coumaroylputrescine, +2.97-fold) and phenolic acids (e.g., Syringic acid, +3.69-fold). Transcriptomic profiling identified 22,525 DEGs, including 3,852 genes enriched in cold adaptation pathways including plant hormone signaling, MAPK signaling and glutathione metabolism. Key regulators of polyamine and phenolic acid metabolism were identified, including aldehyde dehydrogenase, arginine decarboxylase, polyamine oxidase (<i>PAO</i>), S-adenosylmethionine decarboxylase and aspartate aminotransferase, with downregulation of <i>PAO</i> promoting salidroside accumulation but simultaneously suppressing methylated indole-3-acetic acid. Moreover, the reduced accumulation of flavonoids may be linked to the expression of flavonoid 3'-monooxygenase. Furthermore, it was discovered that the ETH, JA-lle, SA, and MAPK signaling pathways play an active role in the signaling of <i>P. veitchii</i> roots during the response to cold stress. This study offers valuable insights into the complex regulatory mechanisms that govern the cold stress response in <i>P. veitchii</i> roots, thereby establishing a theoretical basis for a more comprehensive comprehension of its response and adaptation mechanisms to cold stress.
DOI: 10.6084/m9.figshare.29279675.v1
title: <b>的转录组学分析和抗寒</b><b><i>芍药</i></b>

description: <i>芍药是一种</i>重要的经济植物，以其卓越的药用价值和非凡的耐寒性而闻名。<i> </i>然而，其耐寒性的分子机制仍不清楚。在本研究中，采用生理分析和多组学技术相结合的综合方法研究了<i> P. veitchii</i>。代谢组学分析显示，在低温胁迫下，61 种代谢物的水平发生显著变化，其中多胺（例如，对香豆酰腐胺，+2.97 倍）和酚酸（例如，丁香酸，+3.69 倍）显著增加。转录组学分析鉴定了 22,525 个 DEGs，包括 3,852 个富含植物激素信号传导、MAPK 信号传导和谷胱甘肽代谢等冷适应途径的基因。确定了多胺和酚酸代谢的关键调节因子，包括醛脱氢酶、精氨酸脱羧酶、多胺氧化酶 （<i>PAO</i>）、S-腺苷甲硫氨酸脱羧酶和天冬氨酸氨基转移酶，其中 <i>PAO</i>促进红景天苷积累，但同时抑制甲基化吲哚-3-乙酸。此外，类黄酮积累的减少可能与类黄酮 3'-单加氧酶的表达有关。此外，研究发现 ETH 、 JA-lle 、 SA 和 MAPK 信号通路在<i>P. veitchii</i>。本研究为控制 <i>P. veitchii</i>，从而为更全面地理解其对寒冷胁迫的响应和适应机制奠定了理论基础。
DOI: 10.5281/zenodo.15645076
title: Sustaining SME Performance under Turbulent Conditions: The Synergistic Role of Digital and Network Capabilities through Collaborative Innovation in Emerging Markets
DOI: 10.5281/zenodo.15645077
title: Sustaining SME Performance under Turbulent Conditions: The Synergistic Role of Digital and Network Capabilities through Collaborative Innovation in Emerging Markets
DOI: 10.15468/dl.b268gf
title: Occurrence Download

description: A dataset containing 2869 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Lates niloticus (Linnaeus, 1758))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2869 records from 48 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037627-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48349/asu/gxb8e0
title: APPLE (Assessing Positive Peer Learning Environments) Partnership

description: Given that there has been no focused examination of gender integration in classrooms in almost 40 years, this project focused on reexamining this issue to better understand how boys and girls in contemporary US classrooms are (or are not) engaged with each other and the impact this has on academic outcomes (school engagement, academic perceptions and achievement). These files include SPSS datasets and a Codebook of data gathered from 3 cohorts of 3rd, 4th, and 5th grade students and their teachers on the current state of gender integration in upper elementary school classrooms.
description: IBM SPSS Statistics, 28
DOI: 10.15468/dl.hghs5t
title: Occurrence Download

description: A dataset containing 3072 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (NSW BioNet Atlas, ALA species sightings and OzAtlas, NatureMapr, Sustainable Rivers Audit, iNaturalist Research-grade Observations, Eremaea, FeralScan, BirdLife Australia, Birdata, EOD – eBird Observation Dataset, IMOS - Animal Tracking Facility - Acoustic Tracking - Quality Controlled Detections (2007 -2021))",
 "Geometry POLYGON((149.3222 -36.63558,149.6414 -36.66994,149.8052 -36.61731,150.08308 -36.30429,150.11087 -36.01299,150.1044 -35.60351,149.89175 -35.4584,149.61362 -35.53277,149.51846 -35.96415,149.3222 -36.63558))",
 "HasGeospatialIssue is false",
 "IucnRedListCategory is NT",
 "OccurrenceStatus is Present",
 "Year 2009-2019"
 ]
}

 The dataset includes 3072 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037629-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8sq49y
title: Occurrence Download

description: A dataset containing 376 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Heterotis niloticus (Cuvier, 1829))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 376 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037630-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29299280
title: Data and Code for manuscript titled: "How strong is enemy release? A systematic compilation across taxa and approaches."

description: This item contains two files:"How-strong-is-enemy-release.csv" is a UFT-8 CSV containing the cleaned data used in the manuscript titled "How strong is enemy release? A systematic compilation across taxa and approaches.""How-strong-is-enemy-release.zip" is a R project file containing code used to clean and analyse data for manuscript titled "How strong is enemy release? A systematic compilation across taxa and approaches.". Written using R version 4.2.1.
DOI: 10.6084/m9.figshare.29299280.v1
title: Data and Code for manuscript titled: "How strong is enemy release? A systematic compilation across taxa and approaches."

description: This item contains two files:"How-strong-is-enemy-release.csv" is a UFT-8 CSV containing the cleaned data used in the manuscript titled "How strong is enemy release? A systematic compilation across taxa and approaches.""How-strong-is-enemy-release.zip" is a R project file containing code used to clean and analyse data for manuscript titled "How strong is enemy release? A systematic compilation across taxa and approaches.". Written using R version 4.2.1.
DOI: 10.15468/dl.stcqac
title: Occurrence Download

description: A dataset listing the 62 species recorded in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry MULTIPOLYGON (((-67.42956 48.87034, -67.43502 48.86999, -67.43311 48.86374, -67.42291 48.86032, -67.41899 48.85679, -67.42326 48.85454, -67.41328 48.84693, -67.39059 48.8456, -67.3855 48.84136, -67.38195 48.83441, -67.38555 48.83247, -67.37977 48.82774, -67.37268 48.82689, -67.36477 48.8264, -67.36194 48.82611, -67.35826 48.82633, -67.35947 48.83014, -67.36398 48.83699, -67.36937 48.84129, -67.36876 48.84493, -67.3614 48.85547, -67.36869 48.8562, -67.37096 48.85553, -67.37611 48.85816, -67.37887 48.86108, -67.38318 48.86401, -67.40109 48.86518, -67.40689 48.86574, -67.41267 48.86413, -67.42956 48.87034)))"
 ]
}

 The dataset's 62 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037626-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.