cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5759613
title: Supplementary Material for: Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

description: <b><i>Objective:</i></b> Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our study was aimed at investigating distinctive phenotypes conferred by different mutations within this class. <b><i>Methods:</i></b> We examined the two most prevalent mutations, D538G and Y537S, employing corroborative genome-edited and lentiviral-transduced ER+ T47D cell models. We used a luciferase-based reporter and endogenous phospho-ER immunoblot analysis to characterize the estrogen response of ER mutants and determined their resistance to known ER antagonists.<b><i> Results:</i></b> Consistent with their selection during estrogen deprivation therapy, these mutants conferred constitutive ER activity. While Y537S mutants showed no estrogen dependence, D538G mutants demonstrated an enhanced estrogen-dependent response. Both mutations conferred resistance to ER antagonists that was overcome at higher doses acting specifically through their ER target. <b><i>Conclusions:</i></b> These observations provide a tenable hypothesis for how D538G ESR1-expressing clones can contribute to shorter progression-free survival observed in the exemestane arm of the BOLERO-2 study. Thus, in those patients with dominant D538G-expressing clones, longitudinal analysis for this mutation in circulating free DNA may prove beneficial for informing more optimal therapeutic regimens.
DOI: 10.6084/m9.figshare.5759613.v1
title: Supplementary Material for: Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

description: <b><i>Objective:</i></b> Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our study was aimed at investigating distinctive phenotypes conferred by different mutations within this class. <b><i>Methods:</i></b> We examined the two most prevalent mutations, D538G and Y537S, employing corroborative genome-edited and lentiviral-transduced ER+ T47D cell models. We used a luciferase-based reporter and endogenous phospho-ER immunoblot analysis to characterize the estrogen response of ER mutants and determined their resistance to known ER antagonists.<b><i> Results:</i></b> Consistent with their selection during estrogen deprivation therapy, these mutants conferred constitutive ER activity. While Y537S mutants showed no estrogen dependence, D538G mutants demonstrated an enhanced estrogen-dependent response. Both mutations conferred resistance to ER antagonists that was overcome at higher doses acting specifically through their ER target. <b><i>Conclusions:</i></b> These observations provide a tenable hypothesis for how D538G ESR1-expressing clones can contribute to shorter progression-free survival observed in the exemestane arm of the BOLERO-2 study. Thus, in those patients with dominant D538G-expressing clones, longitudinal analysis for this mutation in circulating free DNA may prove beneficial for informing more optimal therapeutic regimens.
DOI: 10.6084/m9.figshare.5759598
title: Measures of intact prey items

description: Data related maximum size of intact prey recognized from Hydromantes stomach contents.
DOI: 10.6084/m9.figshare.5759598.v1
title: Measures of intact prey items

description: Data related maximum size of intact prey recognized from Hydromantes stomach contents.
DOI: 10.6084/m9.figshare.5759595
title: Data on the diet of Hydromantes salamanders

description: Data are related to 1,250 salamanders from 19 different populations. For each salamanders is shown the stomach condition and all prey items recognized at order level
DOI: 10.6084/m9.figshare.5759595.v1
title: Data on the diet of Hydromantes salamanders

description: Data are related to 1,250 salamanders from 19 different populations. For each salamanders is shown the stomach condition and all prey items recognized at order level
DOI: 10.6084/m9.figshare.5759586
title: Characterization of tetrathionate hydrolase from the marine acidophilic sulfur-oxidizing bacterium, <i>Acidithiobacillus thiooxidans</i> strain SH

description: Tetrathionate hydrolase (4THase), a key enzyme of the S<sub>4</sub>-intermediate (S4I) pathway, was partially purified from marine acidophilic bacterium, <i>Acidithiobacillus thiooxidans</i> strain SH, and the gene encoding this enzyme (SH-<i>tth</i>) was identified. SH-Tth is a homodimer with a molecular mass of 97 ± 3 kDa, and contains a subunit 52 kDa in size. Enzyme activity was stimulated in the presence of 1 M NaCl, and showed the maximum at pH 3.0. Although 4THases from <i>A. thiooxidans</i> and the closely related <i>Acidithiobacillus caldus</i> strain have been reported to be periplasmic enzymes, SH-Tth seems to be localized on the outer membrane of the cell, and acts as a peripheral protein. Furthermore, both 4THase activity and SH-Tth proteins were detected in sulfur-grown cells of strain SH. These results suggested that SH-Tth is involved in elemental sulfur-oxidation, which is distinct from sulfur-oxidation in other sulfur-oxidizing strains such as <i>A. thiooxidans</i> and <i>A. caldus</i>. SH-Tth from the marine bacterium exhibited halophilic features distinct from those of the limnetic <i>Af-</i>Tth.
DOI: 10.6084/m9.figshare.5759586.v1
title: Characterization of tetrathionate hydrolase from the marine acidophilic sulfur-oxidizing bacterium, <i>Acidithiobacillus thiooxidans</i> strain SH

description: Tetrathionate hydrolase (4THase), a key enzyme of the S<sub>4</sub>-intermediate (S4I) pathway, was partially purified from marine acidophilic bacterium, <i>Acidithiobacillus thiooxidans</i> strain SH, and the gene encoding this enzyme (SH-<i>tth</i>) was identified. SH-Tth is a homodimer with a molecular mass of 97 ± 3 kDa, and contains a subunit 52 kDa in size. Enzyme activity was stimulated in the presence of 1 M NaCl, and showed the maximum at pH 3.0. Although 4THases from <i>A. thiooxidans</i> and the closely related <i>Acidithiobacillus caldus</i> strain have been reported to be periplasmic enzymes, SH-Tth seems to be localized on the outer membrane of the cell, and acts as a peripheral protein. Furthermore, both 4THase activity and SH-Tth proteins were detected in sulfur-grown cells of strain SH. These results suggested that SH-Tth is involved in elemental sulfur-oxidation, which is distinct from sulfur-oxidation in other sulfur-oxidizing strains such as <i>A. thiooxidans</i> and <i>A. caldus</i>. SH-Tth from the marine bacterium exhibited halophilic features distinct from those of the limnetic <i>Af-</i>Tth.
DOI: 10.6084/m9.figshare.5759538
title: UNESCO cultural World Heritage in the Mediterranean coastal zone

description: These datasets include UNESCO cultural World Heritage sites (WHS) located in the Low Elevation Coastal Zone (LECZ) of the Mediterranean region as of 2018. The data have been produced within a study that assesses Mediterranean UNESCO World Heritage at risk from coastal flooding and erosion due to sea-level rise until 2100. <br>We have produced one dataset of so-called serial nominations, including all those cases where a WHS consists of more than one site, and one aggregated dataset of the main inscribed WHS. <br>The shapes of the WHS (serial and main) are available in polygon vector format in geographic coordinates (WGS84). The attribute tables are available in text format (CSV). For further information, please see the README file and the paper published based on these data:<br>Reimann, L, Vafeidis, AT, Brown, S, Hinkel, J, Tol, RSJ (2018). Mediterranean UNESCO World Heritage at risk from coastal flooding and erosion due to sea-level rise. Nature Communications 9: 4161, doi: 10.1038/s41467-018-06645-9.<br>Please cite the paper along with this repository when using the data. Suggested data citation:Reimann, L, Vafeidis, AT, Brown, S, Hinkel, J, Tol, RSJ (2018): UNESCO cultural World Heritage in the Mediterranean coastal zone. Available at https://doi.org/10.6084/m9.figshare.5759538.
DOI: 10.6084/m9.figshare.5759532
title: Partition flie of rrnS by IQ-TREE

description: Partition flie of <i>rrnS</i> by IQ-TREE
DOI: 10.6084/m9.figshare.5759529
title: Aligment flie of rrnS by IQ-TREE

description: Aligment flie of <i>rrnS</i> by IQ-TREE
DOI: 10.6084/m9.figshare.5759523
title: Alignment and partition file of rrnS by MrBayes

description: Alignment and partition file of rrnS by MrBayes
DOI: 10.6084/m9.figshare.5759523.v1
title: Alignment and partition file of rrnS by MrBayes

description: Alignment and partition file of rrnS by MrBayes
DOI: 10.6084/m9.figshare.5759520
title: Survey.sav

description: Full data set Ego Depletion Survey<br>
DOI: 10.6084/m9.figshare.5759517
title: Alignment and partition file of PCGs by MrBayes

description: Alignment and partition file of PCGs by MrBayes
DOI: 10.6084/m9.figshare.5759514
title: Alignment flie of PCGs by IQ-TREE

description: Alignment flie of PCGs by IQ-TREE
DOI: 10.6084/m9.figshare.5759514.v1
title: Alignment flie of PCGs by IQ-TREE

description: Alignment flie of PCGs by IQ-TREE
DOI: 10.6084/m9.figshare.5759508
title: Partition flie of PCGs by IQ-TREE

description: Partition flie of PCGs by IQ-TREE
DOI: 10.6084/m9.figshare.5759478
title: Supplementary Material for: Benefits of Individualized Feedback in Internet-Based Interventions for Depression: A Randomized Controlled Trial

description: <b><i>Background:</i></b> Even though there is an increasing number of studies on the efficacy of Internet-based interventions (IBI) for depression, experimental trials on the benefits of added guidance by clinicians are scarce and inconsistent. This study compared the efficacy of semistandardized feedback provided by psychologists with fully standardized feedback in IBI. <b><i>Methods:</i></b> Participants with mild-to-moderate depression (<i>n = </i>1,089, 66% female) from the client pool of a health insurance company participated in a cognitive-behavioral IBI targeting depression over 6 weeks. Individuals were randomized to weekly semistandardized e-mail feedback from psychologists (individual counseling; IC) or to automated, standardized feedback where a psychologist could be contacted on demand (CoD). The contents and tasks were identical across conditions. The primary outcome was depression; secondary outcomes included anxiety, rumination, and well-being. Outcomes were assessed before and after the intervention and 3, 6, and 12 months later. Changes in outcomes were evaluated using latent change score modeling. <b><i>Results:</i></b> Both interventions yielded large pre-post effects on depression (Beck Depression Inventory-II: <i>d</i><sub>IC</sub> = 1.53, <i>d</i><sub>CoD</sub> = 1.37; Patient Health Questionnaire-9: <i>d</i><sub>IC</sub> = 1.20, <i>d</i><sub>CoD</sub> = 1.04), as well as significant improvements of all other outcome measures. The effects remained significant after 3, 6, and 12 months. The groups differed with regard to attrition (IC: 17.3%, CoD: 25.8%, <i>p</i> = 0.001). Between-group effects were statistically nonsignificant across outcomes and measurement occasions. <b><i>Conclusion:</i></b> Adding semistandardized guidance in IBI for depression did not prove to be more effective than fully standardized feedback on primary and secondary outcomes, but it had positive effects on attrition.
DOI: 10.6084/m9.figshare.5759427
title: Sample DataSet for PlosOne

description: Supporting Files for Plos One Submission.<br>
DOI: 10.6084/m9.figshare.5759427.v1
title: Sample DataSet for PlosOne

description: Supporting Files for Plos One Submission.<br>
DOI: 10.6084/m9.figshare.5759328
title: Additional file 7: Table S4. of Cattle infection response network and its functional modules

description: Functional enrichment analysis of close neighbors (TOMâ &gt;â 0. 1) of 85 un-annotated genes in the network. (XLSX 50Â kb)
DOI: 10.6084/m9.figshare.5759328.v1
title: Additional file 7: Table S4. of Cattle infection response network and its functional modules

description: Functional enrichment analysis of close neighbors (TOMâ &gt;â 0. 1) of 85 un-annotated genes in the network. (XLSX 50Â kb)
DOI: 10.6084/m9.figshare.5759313
title: Additional file 6: Table S3. of Cattle infection response network and its functional modules

description: Over-represented GO/Pathway terms in the “green”, “saddle brown”, “light yellow” and “blue” module hub genes. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.5759313.v1
title: Additional file 6: Table S3. of Cattle infection response network and its functional modules

description: Over-represented GO/Pathway terms in the “green”, “saddle brown”, “light yellow” and “blue” module hub genes. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.5759259
title: Additional file 2: of Molecular characterization of larval development from fertilization to metamorphosis in a reef-building coral

description: Full GO results from Fishers exact test of genes in each module (XLSX 36Â kb)
DOI: 10.6084/m9.figshare.5759259.v1
title: Additional file 2: of Molecular characterization of larval development from fertilization to metamorphosis in a reef-building coral

description: Full GO results from Fishers exact test of genes in each module (XLSX 36Â kb)
DOI: 10.6084/m9.figshare.5759235
title: Additional file 2: Table S2. of Cattle infection response network and its functional modules

description: Over-represented GO/Pathway terms in the co-expressed modules. (XLSX 206Â kb)
DOI: 10.6084/m9.figshare.5759235.v1
title: Additional file 2: Table S2. of Cattle infection response network and its functional modules

description: Over-represented GO/Pathway terms in the co-expressed modules. (XLSX 206Â kb)
DOI: 10.6084/m9.figshare.5759217
title: Additional file 1: Table S1. of Cattle infection response network and its functional modules

description: Module membership, connectivity and expression pattern of 14,499 probe-sets used in this study. (XLSX 1290Â kb)
DOI: 10.6084/m9.figshare.5759217.v1
title: Additional file 1: Table S1. of Cattle infection response network and its functional modules

description: Module membership, connectivity and expression pattern of 14,499 probe-sets used in this study. (XLSX 1290Â kb)
DOI: 10.6084/m9.figshare.12895172
title: Metadata for the figures in Lim & Ruthazer, 2020

description: These spreadsheets contain the quantitative data used for analysis and figure generation in the paper.
DOI: 10.6084/m9.figshare.5759058
title: Additional file 6: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Claim volumes analysis. R code, claim volumes analysis and plot. R Markdown file. (RMD 15 kb)
DOI: 10.6084/m9.figshare.5759058.v1
title: Additional file 6: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Claim volumes analysis. R code, claim volumes analysis and plot. R Markdown file. (RMD 15 kb)
DOI: 10.6084/m9.figshare.5759040
title: Additional file 5: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Sensitivity plots R code, sensitivity plots.Â R Markdown file. (RMD 28 kb)
DOI: 10.6084/m9.figshare.5759040.v1
title: Additional file 5: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Sensitivity plots R code, sensitivity plots.Â R Markdown file. (RMD 28 kb)
DOI: 10.6084/m9.figshare.9847436.v1
title: wild dolphin fecal microbiota

description: Sequence data after merging and quality check obtained from feces of 10 wild Indo-Pacific bottlenose dolphins and 2 seawater samples around Mikura Island, Tokyo, Japan.
DOI: 10.6084/m9.figshare.5759019
title: Additional file 4: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Sensitivity analyses. R code, sensitivity analyses. R Markdown file. (RMD 19 kb)
DOI: 10.6084/m9.figshare.5759019.v1
title: Additional file 4: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Sensitivity analyses. R code, sensitivity analyses. R Markdown file. (RMD 19 kb)
DOI: 10.6084/m9.figshare.5759004
title: Additional file 3: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Main plots R code, main plots. R Markdown file. (RMD 26 kb)
DOI: 10.6084/m9.figshare.5759004.v1
title: Additional file 3: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Main plots R code, main plots. R Markdown file. (RMD 26 kb)
DOI: 10.6084/m9.figshare.5758980
title: Additional file 2: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Main analyses R code, main analyses. R Markdown file. (RMD 16 kb)
DOI: 10.6084/m9.figshare.5758980.v1
title: Additional file 2: of Effectiveness of employer financial incentives in reducing time to report worker injury: an interrupted time series study of two Australian workersâ compensation jurisdictions

description: Main analyses R code, main analyses. R Markdown file. (RMD 16 kb)
DOI: 10.6084/m9.figshare.9847436.v2
title: wild dolphin fecal microbiota

description: Sequence data after merging and quality check obtained from feces of 10 wild Indo-Pacific bottlenose dolphins <i>Tursiops aduncus</i> and 2 seawater samples around Mikura Island, Tokyo, Japan.
DOI: 10.6084/m9.figshare.5758962
title: Additional file 1: Tables S1-S9. of Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

description: (XLSX 101 kb)
DOI: 10.6084/m9.figshare.5758962.v1
title: Additional file 1: Tables S1-S9. of Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

description: (XLSX 101 kb)
DOI: 10.6084/m9.figshare.5758902
title: Additional file 2: of The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC)

description: P-values of 176 Yang pathways among BC subtypes. 71 Yang pathways were selected with p
DOI: 10.6084/m9.figshare.5758902.v1
title: Additional file 2: of The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC)

description: P-values of 176 Yang pathways among BC subtypes. 71 Yang pathways were selected with p
DOI: 10.6084/m9.figshare.5758887
title: Additional file 1: of Using Resistin, glucose, age and BMI to predict the presence of breast cancer

description: R script with the algorithm implementation. (ZIP 330 kb)
DOI: 10.6084/m9.figshare.5758878
title: Additional file 1: of The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC)

description: FDRs of 191 Yin . 133 Yin pathways were selected with PDF
DOI: 10.6084/m9.figshare.5758872
title: Additional file 1: of Exploring narratives of resilience among seven males living with spinal cord injury: a qualitative study

description: Interview guide. (ODT 7 kb)
DOI: 10.6084/m9.figshare.5758872.v1
title: Additional file 1: of Exploring narratives of resilience among seven males living with spinal cord injury: a qualitative study

description: Interview guide. (ODT 7 kb)
DOI: 10.6084/m9.figshare.5758839
title: Dataset for: Phanerozoic survivors: actinopterygian evolution through the Permo-Triassic and Triassic-Jurassic mass extinction events

description: Actinopterygians (ray-finned fishes) successfully passed through four of the big five mass extinction events of the Phanerozoic, but the effects of these crises on the group are poorly understood. Many researchers have assumed that the Permo-Triassic mass extinction (PTME) and end-Triassic extinction (ETE) had little impact on actinopterygians, despite devastating many other groups. Here, two morphometric techniques, geometric (body shape) and functional (jaw morphology), are used to assess the effects of these two extinction events on the group. The PTME elicits no significant shifts in functional disparity while body shape disparity increases. An expansion of body shape and functional disparity coincides with the neopterygian radiation and evolution of novel feeding adaptations in the Middle-Late Triassic. Through the ETE, small decreases are seen in shape and functional disparity, but are unlikely to represent major changes brought about by the extinction event. In the Early Jurassic, further expansions into novel areas of ecospace indicative of durophagy occur, potentially linked to losses in the ETE. As no evidence is found for major perturbations in actinopterygian evolution through either extinction event, the group appears to have been immune to two major environmental crises that were disastrous to most other organisms.
DOI: 10.6084/m9.figshare.5758839.v1
title: Dataset for: Phanerozoic survivors: actinopterygian evolution through the Permo-Triassic and Triassic-Jurassic mass extinction events

description: Actinopterygians (ray-finned fishes) successfully passed through four of the big five mass extinction events of the Phanerozoic, but the effects of these crises on the group are poorly understood. Many researchers have assumed that the Permo-Triassic mass extinction (PTME) and end-Triassic extinction (ETE) had little impact on actinopterygians, despite devastating many other groups. Here, two morphometric techniques, geometric (body shape) and functional (jaw morphology), are used to assess the effects of these two extinction events on the group. The PTME elicits no significant shifts in functional disparity while body shape disparity increases. An expansion of body shape and functional disparity coincides with the neopterygian radiation and evolution of novel feeding adaptations in the Middle-Late Triassic. Through the ETE, small decreases are seen in shape and functional disparity, but are unlikely to represent major changes brought about by the extinction event. In the Early Jurassic, further expansions into novel areas of ecospace indicative of durophagy occur, potentially linked to losses in the ETE. As no evidence is found for major perturbations in actinopterygian evolution through either extinction event, the group appears to have been immune to two major environmental crises that were disastrous to most other organisms.
DOI: 10.6084/m9.figshare.5758833
title: Kalara: Reveal, Make Seen

description: This poster was published for a the NCIS Research Conference at the Australian National University (Canberra) in April 2017. It details the methodology I have used in my PhD centered around collaborative filmmaking practice. <br>Graphic Design: Alexander Hayes
DOI: 10.6084/m9.figshare.5758797
title: 2018

description: ssssdd
DOI: 10.6084/m9.figshare.5758797.v1
title: 2018

description: ssssdd
DOI: 10.6084/m9.figshare.5758794
title: test geotiff

description: tiff<br>
DOI: 10.6084/m9.figshare.5758782
title: MODND1T.20100101.CN.NDVI.V2.TIF

description: geotiff