cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19518542
title: Additional file 11 of Novel drug-target interactions via link prediction and network embedding

description: Additional file 11: Table S2. Predicted drugs for MMP14 and ADAM1. List of potential approved drugs that can target MMP14 and ADAM17.
DOI: 10.6084/m9.figshare.19518542.v1
title: Additional file 11 of Novel drug-target interactions via link prediction and network embedding

description: Additional file 11: Table S2. Predicted drugs for MMP14 and ADAM1. List of potential approved drugs that can target MMP14 and ADAM17.
DOI: 10.6084/m9.figshare.19174433
title: Supplementary Material for: Objective response by mRECIST to initial lenvatinib therapy is an independent factor contributing to deep response in hepatocellular carcinoma treated with lenvatinib-transcatheter arterial chemoembolization sequential therapy

description: Objective: There is limited information regarding the benefits of Lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for unresectable hepatocellular carcinoma (u-HCC). We compared the efficacy and safety of LEN-TACE sequential therapy to LEN monotherapy and investigated the factors contributing to the LEN-TACE sequential therapy deep response. Methods: We enrolled a multi-center cohort of 247 patients with u-HCC treated with LEN between 2018 and 2020. Propensity score matching identified sixty-three matching pairs of patients with well-balanced characteristics. We retrospectively compared the clinical outcomes, including overall survival (OS), progression-free survival (PFS), and incidence of adverse events (AEs), between the LEN-TACE and LEN monotherapy groups. Additionally, we evaluated the tumor response, change in albumin-bilirubin (ALBI) score, factors affecting PFS and OS, and independent predictors contributing to the LEN-TACE sequential therapy deep response. In this study, at eight weeks after resumption of LEN after initial TACE, "deep response" was defined as achieving CR or PR on mRECIST, and at least a 30% decrease in the sum of diameters of target lesions, taking the baseline sum diameters as the reference. Results: The OS and PFS in the LEN-TACE group were significantly higher than those in the LEN monotherapy group (P = 0.002 and P = 0.037, respectively). The incidence of AEs related to LEN was not significantly different between the two groups. In LEN-TACE sequential therapy, the objective response rate was 61.9%, and the disease control rate was 74.6%, according to the mRECIST criteria. No significant change in the ALBI score was observed during sequential LEN-TACE therapy. Multivariable analyses revealed that deep response was independently associated with the outcome of the initial response to LEN by mRECIST: PR (odds ratio: 13.75, 95% CI: 0.41–1.32, P &lt;0.001). Conclusions: LEN-TACE sequential therapy may provide more clinical benefits than LEN monotherapy in u-HCC patients who responded to initial LEN treatment. Objective response according to mRECIST to initial LEN is an independent factor contributing to LEN-TACE sequential therapy deep response.
DOI: 10.6084/m9.figshare.19174433.v1
title: Supplementary Material for: Objective response by mRECIST to initial lenvatinib therapy is an independent factor contributing to deep response in hepatocellular carcinoma treated with lenvatinib-transcatheter arterial chemoembolization sequential therapy

description: Objective: There is limited information regarding the benefits of Lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for unresectable hepatocellular carcinoma (u-HCC). We compared the efficacy and safety of LEN-TACE sequential therapy to LEN monotherapy and investigated the factors contributing to the LEN-TACE sequential therapy deep response. Methods: We enrolled a multi-center cohort of 247 patients with u-HCC treated with LEN between 2018 and 2020. Propensity score matching identified sixty-three matching pairs of patients with well-balanced characteristics. We retrospectively compared the clinical outcomes, including overall survival (OS), progression-free survival (PFS), and incidence of adverse events (AEs), between the LEN-TACE and LEN monotherapy groups. Additionally, we evaluated the tumor response, change in albumin-bilirubin (ALBI) score, factors affecting PFS and OS, and independent predictors contributing to the LEN-TACE sequential therapy deep response. In this study, at eight weeks after resumption of LEN after initial TACE, "deep response" was defined as achieving CR or PR on mRECIST, and at least a 30% decrease in the sum of diameters of target lesions, taking the baseline sum diameters as the reference. Results: The OS and PFS in the LEN-TACE group were significantly higher than those in the LEN monotherapy group (P = 0.002 and P = 0.037, respectively). The incidence of AEs related to LEN was not significantly different between the two groups. In LEN-TACE sequential therapy, the objective response rate was 61.9%, and the disease control rate was 74.6%, according to the mRECIST criteria. No significant change in the ALBI score was observed during sequential LEN-TACE therapy. Multivariable analyses revealed that deep response was independently associated with the outcome of the initial response to LEN by mRECIST: PR (odds ratio: 13.75, 95% CI: 0.41–1.32, P &lt;0.001). Conclusions: LEN-TACE sequential therapy may provide more clinical benefits than LEN monotherapy in u-HCC patients who responded to initial LEN treatment. Objective response according to mRECIST to initial LEN is an independent factor contributing to LEN-TACE sequential therapy deep response.
DOI: 10.5517/ccdc.csd.cc26s48f
title: CCDC 2048984: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, George A. Koutsantonis, Max Roemer|2020|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc2bg9qv
title: CCDC 2158707: Experimental Crystal Structure Determination

description: Related Article: Hannes Vitze, Michael Bolte, Matthias Wagner|2022|CSD Communication|||
DOI: 10.6084/m9.figshare.19277976
title: Pharmacotherapeutic combinations for the treatment of Alzheimer’s disease

description: Alzheimer’s disease (AD) is the most common form of dementia, and four medications are currently available as symptomatic therapies: three cholinesterase inhibitors (ChEI) and memantine. In June 2021, aducanumab was approved in the United States under an accelerated approval pathway as the first novel putative disease-modifying therapy (p-DMT) targeting the <i>β</i>-amyloid (A<i>β</i>) cascade in the brain. The combination of several monotherapies to address the multifactorial pathogenesis of neurodegenerative diseases is an anticipated next step. The cholinergic hypothesis and the amyloid cascade hypothesis have been proposed as explanations for the pathogenesis of AD. Given the limited effectiveness of monotherapies based on these hypotheses, approaches using combination therapy are attempting to address the complexity of AD pathogenesis, including putative causative proteins-related neurodegeneration, neurotransmitters, and neuroinflammation, in a comprehensive manner. The efficacy of an initial or add-on combination approach to counteracting neurodegenerative processes and functional deterioration has been investigated. The combination of symptomatic therapies with approved anti-dementia medicines (one ChEI and memantine) has been found to be functionally effective for a moderately severe disease stage. Furthermore, combination strategies involving p-DMTs, symptomatic therapies, and neuro-regeneration may be useful in the future.
DOI: 10.6084/m9.figshare.19277976.v1
title: Pharmacotherapeutic combinations for the treatment of Alzheimer’s disease

description: Alzheimer’s disease (AD) is the most common form of dementia, and four medications are currently available as symptomatic therapies: three cholinesterase inhibitors (ChEI) and memantine. In June 2021, aducanumab was approved in the United States under an accelerated approval pathway as the first novel putative disease-modifying therapy (p-DMT) targeting the <i>β</i>-amyloid (A<i>β</i>) cascade in the brain. The combination of several monotherapies to address the multifactorial pathogenesis of neurodegenerative diseases is an anticipated next step. The cholinergic hypothesis and the amyloid cascade hypothesis have been proposed as explanations for the pathogenesis of AD. Given the limited effectiveness of monotherapies based on these hypotheses, approaches using combination therapy are attempting to address the complexity of AD pathogenesis, including putative causative proteins-related neurodegeneration, neurotransmitters, and neuroinflammation, in a comprehensive manner. The efficacy of an initial or add-on combination approach to counteracting neurodegenerative processes and functional deterioration has been investigated. The combination of symptomatic therapies with approved anti-dementia medicines (one ChEI and memantine) has been found to be functionally effective for a moderately severe disease stage. Furthermore, combination strategies involving p-DMTs, symptomatic therapies, and neuro-regeneration may be useful in the future.
DOI: 10.6084/m9.figshare.19518385
title: Velocity measurements at South China Sea

description: The observation site is located on the northern slope of the South China Sea (20.08°N, 115.2°E), with a water depth of 659 m. A bottom landing frame was deployed at the site from 00:00 on August 21, 2020 to 12:00 on August 22, with an observation duration of 36 h. The frame was equipped with velocity profilers (75k Hz-ADCP and 2M Hz-ADCP) and an Acoustic Doppler velocimetry (ADV). The 75k Hz-ADCP measured full-depth velocity profiles with sampling frequency of 1 Hz (75kHzADCP.mat). The 2M Hz-ADCP measured fine-scale (vertical resolution: 0.007 m) bottom boundary layer velocity profiles with sampling frequency of 1 Hz(2MHzADCP.mat). The ADV measured high frequency velocity (64 Hz) at 0.6 mab (ADV.mat).
DOI: 10.6084/m9.figshare.19518385.v1
title: Velocity measurements at South China Sea

description: The observation site is located on the northern slope of the South China Sea (20.08°N, 115.2°E), with a water depth of 659 m. A bottom landing frame was deployed at the site from 00:00 on August 21, 2020 to 12:00 on August 22, with an observation duration of 36 h. The frame was equipped with velocity profilers (75k Hz-ADCP and 2M Hz-ADCP) and an Acoustic Doppler velocimetry (ADV). The 75k Hz-ADCP measured full-depth velocity profiles with sampling frequency of 1 Hz (75kHzADCP.mat). The 2M Hz-ADCP measured fine-scale (vertical resolution: 0.007 m) bottom boundary layer velocity profiles with sampling frequency of 1 Hz(2MHzADCP.mat). The ADV measured high frequency velocity (64 Hz) at 0.6 mab (ADV.mat).
DOI: 10.5281/zenodo.6413923
title: Local survey network and monitoring data of VLBI telescope at Metsähovi

description: Observations of local surveying network and monitorin at Metsähovi. More information is in file Data_description.pdf.
DOI: 10.5281/zenodo.6413922
title: Local survey network and monitoring data of VLBI telescope at Metsähovi

description: Observations of local surveying network and monitorin at Metsähovi. More information is in file Data_description.pdf.
DOI: 10.5281/zenodo.6411400
title: Data from: Recovering wetland biogeomorphic feedbacks to restore the world's biotic carbon hotspots

description: These datafiles are part of a study that reviews how feedbacks between geomorphology and landscape-building vegetation underlie carbon storage and sequestration, and how feedback disruption can switch wetlands from carbon sinks into sources carbon stocks. Included ecosystems: ocean, forests, peatlands, mangrove forests, salt marshes, and seagrass meadows. Data were collected from other studies. Additional information regarding the methods, references or results of these datasets can be found in: Ralph J.M. Temmink, Leon P.M. Lamers, Christine Angelini, Tjeerd J. Bouma, Christian Fritz, Johan van de Koppel, Robin Lexmond, Max Rietkerk, Brian R. Silliman, Hans Joosten, Tjisse van der Heide. 2022. Recovering wetland biogeomorphic feedbacks to restore the world’s biotic carbon hotspots. <em>Science</em>.
DOI: 10.5281/zenodo.6411399
title: Data from: Recovering wetland biogeomorphic feedbacks to restore the world's biotic carbon hotspots

description: These datafiles are part of a study that reviews how feedbacks between geomorphology and landscape-building vegetation underlie carbon storage and sequestration, and how feedback disruption can switch wetlands from carbon sinks into sources carbon stocks. Included ecosystems: ocean, forests, peatlands, mangrove forests, salt marshes, and seagrass meadows. Data were collected from other studies. Additional information regarding the methods, references or results of these datasets can be found in: Ralph J.M. Temmink, Leon P.M. Lamers, Christine Angelini, Tjeerd J. Bouma, Christian Fritz, Johan van de Koppel, Robin Lexmond, Max Rietkerk, Brian R. Silliman, Hans Joosten, Tjisse van der Heide. 2022. Recovering wetland biogeomorphic feedbacks to restore the world’s biotic carbon hotspots. <em>Science</em>.
DOI: 10.6084/m9.figshare.19518751
title: Supplementary Material for: Exosomal miR-4639 and miR-210 in Plasma and Urine as Biomarkers in IgA Nephropathy

description: <b><i>Background:</i></b> It has been widely recognized that exosomal miRNAs can participate in the pathogenesis of different renal disorders and serve as disease biomarkers. Although kidney biopsy is still the gold standard for diagnosing and monitoring immunoglobulin A nephropathy (IgAN), it is highly required to identify new and effective noninvasive biomarkers for IgAN, the most frequently detected primary glomerulonephritis worldwide. <b><i>Methods:</i></b> Plasma and urinary exosomes were extracted by PEG precipitation. Size and morphological characteristics of plasma and urinary exosomes were observed by transmission electron microscopy and nanoparticle tracking analysis. The levels of plasma and urinary exosomes were revealed by Western blotting. The expressions of target miRNAs were revealed by in situ hybridization and qRT-PCR. <b><i>Results:</i></b> The levels of plasma and urinary exosomes were remarkably enhanced in IgAN patients compared with healthy controls (HCs). The expressions of miR-4639 and miR-210 in IgAN patients were significantly higher in contrast to the individuals with membranous nephropathy, minimal change nephrosis, diabetic nephropathy, or HC. These also played a valuable role in assessing the kidney function and the level of proteinuria. Furthermore, plasma and urinary exosomal miR-4639 expression was associated with more serious and active histological activity (mesangial hypercellularity, crescent, and C3 complement deposition). With an average follow-up of 8 months, miR-4639 and miR-210 expressions in plasma and urinary exosomes were higher in patients with progressive IgAN. Plasma exosomal miR-4639 and miR-210 were better than proteinuria (g/24 h) to estimate renal outcomes. <b><i>Conclusion:</i></b> Exosomal miR-4639 and miR-210 could be used as valid biomarkers to assist in diagnosis, evaluate severity, and assess disease development of IgAN.
DOI: 10.6084/m9.figshare.19518751.v1
title: Supplementary Material for: Exosomal miR-4639 and miR-210 in Plasma and Urine as Biomarkers in IgA Nephropathy

description: <b><i>Background:</i></b> It has been widely recognized that exosomal miRNAs can participate in the pathogenesis of different renal disorders and serve as disease biomarkers. Although kidney biopsy is still the gold standard for diagnosing and monitoring immunoglobulin A nephropathy (IgAN), it is highly required to identify new and effective noninvasive biomarkers for IgAN, the most frequently detected primary glomerulonephritis worldwide. <b><i>Methods:</i></b> Plasma and urinary exosomes were extracted by PEG precipitation. Size and morphological characteristics of plasma and urinary exosomes were observed by transmission electron microscopy and nanoparticle tracking analysis. The levels of plasma and urinary exosomes were revealed by Western blotting. The expressions of target miRNAs were revealed by in situ hybridization and qRT-PCR. <b><i>Results:</i></b> The levels of plasma and urinary exosomes were remarkably enhanced in IgAN patients compared with healthy controls (HCs). The expressions of miR-4639 and miR-210 in IgAN patients were significantly higher in contrast to the individuals with membranous nephropathy, minimal change nephrosis, diabetic nephropathy, or HC. These also played a valuable role in assessing the kidney function and the level of proteinuria. Furthermore, plasma and urinary exosomal miR-4639 expression was associated with more serious and active histological activity (mesangial hypercellularity, crescent, and C3 complement deposition). With an average follow-up of 8 months, miR-4639 and miR-210 expressions in plasma and urinary exosomes were higher in patients with progressive IgAN. Plasma exosomal miR-4639 and miR-210 were better than proteinuria (g/24 h) to estimate renal outcomes. <b><i>Conclusion:</i></b> Exosomal miR-4639 and miR-210 could be used as valid biomarkers to assist in diagnosis, evaluate severity, and assess disease development of IgAN.
DOI: 10.5281/zenodo.6413982
title: Transport-Energy Database: Kenya

description: This Transport-Energy Database (TED) covers technology, energy demand and policies relating to the transport-energy system in Kenya. It was compiled using data sources from the IEA, World Bank, Kenyan Government, EnergyData.info and the TraCs project (https://www.giz.de/en/worldwide/40579.html). All data sources are linked where possible. Data from the Kenyan Statistical Abstract and the TraCs data were manually transcribed from their sources. This dataset was compiled as part of the Climate Compatible Growth (CCG) programme for future work in constructing transport-energy decarbonisation narratives for partner countries, including Kenya. The data was validated in March/April 2022 by Nam Lolwe Environmental Services.
DOI: 10.5281/zenodo.5769710
title: Transport-Energy Database: Kenya

description: This Transport-Energy Database (TED) covers technology, energy demand and policies relating to the transport-energy system in Kenya. It was compiled using data sources from the IEA, World Bank, Kenyan Government, EnergyData.info and the TraCs project (https://www.giz.de/en/worldwide/40579.html). All data sources are linked where possible. Data from the Kenyan Statistical Abstract and the TraCs data were manually transcribed from their sources. This dataset was compiled as part of the Climate Compatible Growth (CCG) programme for future work in constructing transport-energy decarbonisation narratives for partner countries, including Kenya. The data was validated in March/April 2022 by Nam Lolwe Environmental Services.
DOI: 10.17903/fk2/9kmg7n
title: Informational Press Releases of the General Secretariat of Civil Protection on the new coronavirus

description: This is a collection of Press Releases of the General Secretariat for Civil Protection for the new coronavirus. The period covered by the collection is between 12.03.2020 and 04.05.2020. This collection - in addition to the Critical Discourse Analysis that has already taken place (see related publication) - can contribute to the implementation of research projects through applications of secondary text analysis.
DOI: 10.34740/kaggle/dsv/3410351
title: AutoXGB
DOI: 10.5281/zenodo.6413965
title: Supporting data for the submission to the WRR journal

description: It is supporting data for the submission entitled "Uncertainty Quantification of Transient-based Leakage Identification: A Frequency Domain Approach" to the WRR journal. 1. All figures in fig format. 2. Experimental data of the Perugia Test [1], and the Shahid Chamran Test [2]. [1] Keramat, A., Louati, M., Wang, X., Meniconi, S., Brunone, B., Ghidaoui, M.S. (2019). Objective Functions for Transient-Based Pipeline Leakage Detection in a Noisy Environment: Least Square and Matched-Filter. Journal of Water Resources Planning and Management, ASCE, 145(10), 04019042. [2] Rezapour, Shafai Bejestan, M., & Aminnejad, B. (2021). Case study of leak detection based on Gaussian function in experimental viscoelastic water pipeline. Water Science & Technology. Water Supply. https://doi.org/10.2166/ws.2021.145
DOI: 10.5281/zenodo.4898462
title: Supporting data for the submission to the WRR journal

description: It is supporting data for the submission entitled "Uncertainty Quantification of Transient-based Leakage Identification: A Frequency Domain Approach" to the WRR journal. 1. All figures in fig format. 2. Experimental data of the Perugia Test [1], and the Shahid Chamran Test [2]. [1] Keramat, A., Louati, M., Wang, X., Meniconi, S., Brunone, B., Ghidaoui, M.S. (2019). Objective Functions for Transient-Based Pipeline Leakage Detection in a Noisy Environment: Least Square and Matched-Filter. Journal of Water Resources Planning and Management, ASCE, 145(10), 04019042. [2] Rezapour, Shafai Bejestan, M., & Aminnejad, B. (2021). Case study of leak detection based on Gaussian function in experimental viscoelastic water pipeline. Water Science & Technology. Water Supply. https://doi.org/10.2166/ws.2021.145
DOI: 10.5281/zenodo.6413955
title: Realistic soil carbon sequestration considering food security and climate change

description: This dataset contains soil organic carbon stocks as described in Keel et al. Global Change Biology (submitted) Annual soil organic carbon (SOC) stocks (t C ha-1, 0-30 cm depth) of Swiss agricultural soils simulated with the model RothC for the years 2020-2100. Simulations were performed for 240 strata (regions with similar agricultural production types, climatic conditions and clay content). The SOC stocks are weighted averages across strata for the national scale. <br> Each column contains SOC stocks for a specific combination of a climate model chains (nine in total) and an emission scenario (three in total: RCP 26, RCP 45, RCP 85) (specified in column header). The results include simulated SOC stocks for a baseline scenario and five soil carbon sequestration (SCS) scenarios (cover crops, biochar amendment at two rates, biochar amendment based on biomass from two agroforestry scenarios). <br> The SCS scenarios were only performed on cropland, therefore there is only a single file for grassland (the baseline scenario). <br> All simulations (i.e. baseline as well as the five scenarios) account for changes in crop shares and organic matter additions associated with growing food demand as well as climate change. The scenarios are described in Keel et al. Global Change Biology (submitted) CL_baseline: Baseline scenario for cropland (CL) <br> GL_baseline: Baseline scenario for permanent grassland (GL)<br> CL_cover_crops: Cover crop scenario for cropland <br> CL_biochar_I: Biochar I scenario for cropland <br> CL_biochar_II: Biochar II scenario for cropland <br> CL_agroforestry_I: Agroforestry I scenario for cropland <br> CL_agroforestry_II: Agroforestry II scenario for cropland