DOI: 10.3886/icpsr33444.v2
title: Center for Education and Drug Abuse Research (CEDAR): Etiological and Prospective Family Study in Southwestern Pennsylvania, Baseline and Follow-Up Data, 1990-2014
title: Version 2

description: The Center for Education and Drug Abuse Research (CEDAR) conducted research on 775 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). The pro-bands are men with lifetime presence/absence of SUD consequent to use of an illicit drug who have a 10-12 year old biological son or daughter. The biological children of SUD men are assigned to the high average risk (HAR) group whereas offspring of men without SUD, having neither axis 1 disorder ("normal") nor SUD psychiatric disorder, are assigned to the low average risk (LAR) group. A second control group (Psych control) was also collected, in whom the fathers had a lifetime DSM-III-R diagnosis of any psychiatric disorder not related to substance use. The sample sizes are as follows: HAR = 344, LAR = 350, and Psych = 81. The children had follow-up evaluations conducted at ages 12-14, 16, 19, and annually thereafter until age 30. CEDAR has already shown that they can predict in 10-12 year old youth cannabis use disorder by age 22 with approximately 70 percent accuracy, thereby substantiating the paradigm, subject recruitment strategy, and measurement protocols. Multidisciplinary research was conducted on family members (father, mother, children) with the objective of elucidating the genetic, bio-behavioral, and environmental factors on development of SUD consequent to use of illegal drugs. Research protocols are organized into three thematically connected research modules (Neurogenetics, Developmental Psychopathology, and Translation) linking etiology and prevention. The research components thus align with the NIH Roadmap model such that basic science informs clinical research leading to prevention guided by an understanding of etiology. In addition to module-level research, faculty also participate in three organizational aims: (1) Devise a practical scale to quantify the transmissible liability to SUD; (2) Empirically test a bio-psychological theory of SUD etiology focusing on off-time maturation leading to psychological dysregulation predisposing to SUD; and, (3) Delineate SUD liability variants within an ontogenetic framework.
description: Three groups of male and female children are studied for a 20-year period: (1) Offspring of substance abusing fathers, (2) Offspring of normal fathers, and (3) Offspring of psychiatrically disordered fathers. The three groups are longitudinally tracked from age 10-12 until they reach age 30 using the following assessment schedule: age 10-12, age 12-14, age 16, age 19, age 22, age 25, age 27, age 30. Brief annual updates were also collected between ages 19 and 30.
description: Presence of Common Scales: The study utilized the following measurement tools: Child Behavior Checklist (CBCL). Dimensions of Temperament - Revised (DOTs-R). Family Assessment Measure (FAM). Health Problems Checklist (HPQ). Multidimensional Personality Questionnaire (MPQ). Youth Self Report (YSR) Achenbach, T.M. (1991). Manual for the Youth Self-Report and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry. Young Adult Self Report (YASR) Achenbach, T.M. (1997) Manual for the Young Adult Self-Report and Young Adult Behavior Checklist. Burlington, VT: Department of Psychiatry, University of Vermont. Adult Self Report (ASR) Achenbach, T.M., and Rescorla, L.A. (2003). Manual for the ASEBA Adult Forms and Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth and Families. Interpersonal Support Evaluation List (ISEL) Cohen, S. and Hoberman, H.M. (1983). Positive events and social supports as buffers of life change stress. Journal of Applied Social Psychology, 13, 99-125. Social Readjustment Rating Scale Holmes, T.H., and Rahe, R.H. (1967). The social readjustment rating scale. Journal of Psychosomatic Research, 11, 213-218. Life Events Questionnaire Coddington, R.D. (1972). The significance of life events as etiologic factors in the diseases of children. II. Journal of Psychosomatic Research, 16, 205-213.
description: The sample uses a high risk paradigm, in which the families were selected based on a DSM-III-R diagnosis of substance use disorder in the biological father of the index child (High Average Risk, or HAR group) versus NO DSM-III-R psychiatric disorder (Low Average Risk, or LAR group). A second control group (Psych control) was also collected, in whom the fathers had a lifetime DSM-III-R diagnosis of any psychiatric disorder not related to substance use. The sample sizes are as follows: HAR = 344, LAR = 350, and Psych = 81. Citation: Tarter, R.E., Vanyukov, M.M. (2001). Introduction: Theoretical and operational framework for research into the etiology of substance use disorders. Journal of Child and Adolescent Substance Abuse 10 (4):1-12.
description: Datasets: DS0: Study-Level Files DS1: Adult Self Report - Index Case on Self DS2: Carbon Monoxide Monitoring - Index Case DS3: Child Behavior Checklist - Parents on Index Case DS4: Cognitive Error Questionnaire - Index Case DS5: Demographic Form - Father DS6: Demographic Form - Index Case (Visit 1) DS7: Demographic Form - Index Case (Visits 2 to 8) DS8: Demographic Form - Mother DS9: Dimensions of Temperament Survey - Caregiver on Index Case DS10: Dimensions of Temperament Survey - Father on Self DS11: Dimensions of Temperament Survey - Index Case on Self DS12: Dimensions of Temperament Survey - Mother on Self DS13: Drug Use Chart - Caregiver on Index Case DS14: Drug Use Chart - Father on Self DS15: Drug Use Chart - Index Case on Self DS16: Drug Use Chart - Mother on Self DS17: Family Assessment Measure - Dyadic Relationship Scale - Father on Index Case DS18: Family Assessment Measure - Dyadic Relationship Scale - Index Case on Father DS19: Family Assessment Measure - Dyadic Relationship Scale - Index Case on Mother DS20: Family Assessment Measure - Dyadic Relationship Scale - Index Case on Sibling DS21: Family Assessment Measure - Dyadic Relationship Scale - Mother on Index Case DS22: Family Assessment Measure - Dyadic Relationship Scale - Sibling on Index Case DS23: Family Assessment Measure - General Scale - Father on Self DS24: Family Assessment Measure - General Scale - Index Case on Self DS25: Family Assessment Measure - General Scale - Mother on Self DS26: Family Self Rating Scale - Father DS27: Family Self Rating Scale - Index Case DS28: Family Self Rating Scale - Mother DS29: Health Problems Checklist - Father DS30: Health Problems Checklist - Index Case DS31: Health Problems Checklist - Mother DS32: Life Events Inventory - Self Reported - Index Case DS33: Life Events Questionnaire - Self Reported - Index Case DS34: Multidimensional Personality Questionnaire - Father on Self DS35: Multidimensional Personality Questionnaire - Index Case on Self DS36: Multidimensional Personality Questionnaire - Mother on Self DS37: Nursing Assessment - Index Case DS38: Psychiatric History Marker for DSM-III-R - Father DS39: Psychiatric History Marker for DSM-III-R - Index Case DS40: Psychiatric History Marker for DSM-III-R - Mother DS41: Psychiatric History Marker DSM-IV - Father DS42: Psychiatric History Marker DSM-IV - Index Case DS43: Psychiatric History Marker DSM-IV - Mother DS44: Psychiatric Treatment History Questionnaire - Father DS45: Psychiatric Treatment History Questionnaire - Index Case DS46: Psychiatric Treatment History Questionnaire - Mother DS47: Revised Parent Adolescent Communication Scale - Index Case DS48: Social Support Scale (Version 0) - Index Case DS49: Social Support Scale (Version 8) - Index Case DS50: Substance Use Questionnaire - Drug - Index Case DS51: Substance Use Questionnaire - Rank - Index Case DS52: Substance Use Questionnaire - Scale - Index Case DS53: Substance Use Questionnaire - Stop - Index Case DS54: Vigilance Task - Index Case DS55: Young Adult Self Report - Index Case DS56: Youth Self Report - Index Case DS57: Adult Self Report - Sibling as Index DS58: Carbon Monoxide Monitoring - Sibling as Index DS59: Child Behavior Checklist - Parents on Sibling as Index DS60: Demographic Form - Sibling as Index (Visit 1) DS61: Cognitive Error Questionnaire - Sibling as Index DS62: Demographic Form - Sibling as Index (Visits 2 through 8) DS63: Dimensions of Temperament - Caregiver on Sibling as Index DS64: Dimensions of Temperament - Sibling as Index on Self DS65: Drug Screen - Sibling as Index DS66: Drug Use Chart - Caregiver on Sibling as Index DS67: Drug Use Chart - Sibling as Index on Self DS68: Family Assessment Measure - Dyadic Relationship Scale - Sibling as Index Case on Father DS69: Family Assessment Measure - Dyadic Relationship Scale - Sibling as Index Case on Sibling DS70: Family Assessment Measure - General Scale - Sibling as Index on Self DS71: Family Assessment Measure - Self Rating Scale - Sibling as Index on Self DS72: Health Problem Checklist - Sibling as Index on Self DS73: Life Events Inventory - Sibling as Index on Self DS74: Life Events Questionnaire - Sibling as Index on Self DS75: Multidimensional Personality Questionnaire - Sibling as Index on Self DS76: Nursing Assessment - Sibling as Index DS77: Psychiatric History Marker for DSM-III-R - Sibling as Index DS78: Psychiatric History Marker DSM-IV - Sibling as Index DS79: Psychiatric Treatment History Questionnaire - Sibling as Index DS80: Revised Parent Adolescent Communication - Sibling as Index DS81: Social Support Scale - Sibling as Index (Version 0) DS82: Social Support Scale - Sibling as Index (Version 8) DS83: Substance Use Questionnaire - Drug - Sibling as Index DS84: Substance Use Questionnaire - Rank - Sibling as Index DS85: Substance Use Questionnaire - Scale - Sibling as Index DS86: Substance Use Questionnaire - Stop - Sibling as Index DS87: Vigilance Task - Sibling as Index DS88: Young Adult Self Report - Sibling as Index DS89: Youth Self Report - Sibling as Index
description: Fathers, mothers, and biological children ages 10-12 in 1990 in Southeastern Pennsylvania whose father had a lifetime presence/absence of substance abuse disorder consequent to use of an illicit drug. Smallest Geographic Unit: Census tract
description: cognitive assessment test; face-to-face interview; mail questionnaire; paper and pencil interview (PAPI); on-site questionnaire; telephone interviewFor more information regarding the CEDAR study measures, users are encouraged to see the Center for Education and Drug Abuse Research (CEDAR) Web site.