cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27079588.v1
title: Supplementary material for "Early Paleozoic large-scale subduction retreat and slab rollback revealed by mafic arc magmas in the southern Central Asian Orogenic Belt"

description: The northern margin of the Tarim-North China collage features Early Paleozoic arc magmas, rifted terrains, and back-arc basins, yet their tectonic implications remain unclear. Mafic arc magmas may provide critical constraints on the thermal state of subducted slabs and subduction zone dynamics. This study explores the origins and large-scale significance of these magmas, concentrating on mafic rocks in NW China. Findings show they formed at 450 - 420 Ma and are geochemically resemble high-Al arc basalts. The magmas result from melting of sediment melt metasomatized mantle, followed by fractional crystallization of various minerals. The findings, integrated with regional data, reveal a continental arc over 1,500 km along the collage's northern margin, with prevalent slab-derived sediment melts in the sub-arc mantle wedge, indicating high slab surface temperatures (SST). This elevated SST likely arises from asthenosphere upwelling due to slab rollback, which is also responsible for the rifting of marginal terrains and the formation of back-arc basins along the northern edge of the collage. Furthermore, this retreating-type accretionary orogenic belt may globally interconnect to create a subduction girdle, thereby facilitating prolonged dispersal of Gondwana, drift and reunion of its derived continents in Asia, and the opening of the Paleo-Tethys.
DOI: 10.6084/m9.figshare.28601387.v1
title: S1_Dataset.csv

description: This study was conducted to explore the unmet needs and health-related quality of life (QOL) of family caregivers who support cancer patients, and to determine the impact of these unmet needs on their health-related QOL. A descriptive study was conducted from July 1 to July 30, 2023, in which a survey was administered to 129 family caregivers of cancer patients undergoing outpatient treatment at a general hospital of South Korea.
DOI: 10.60893/figshare.ajp.25939774.v1
title: Supplementary Online Material

description: Supplementary materials, containing fluence dependent data and fits, as well as description of measurements
DOI: 10.6084/m9.figshare.20000690.v4
title: Schima barcoding analyses

description: The folder includes alignment matrixes and phylogenetic trees.
DOI: 10.6084/m9.figshare.28148231.v1
title: Advancing Military Medicine Education: Curriculum Integration and Practical Training at the Defence Services Medical Academy

description: <b>Abstract</b><br><b>Introduction:</b> This study examines the integration of military medicine education at the Defence Services Medical Academy (DSMA), assessing the curriculum’s structure, practical training adequacy, and its relevance to the evolving needs of both military and civilian healthcare sectors.<br>Despite the comprehensive nature of DSMA’s curriculum, there are significant gaps in practical training and its continuity, which hinder the academy’s ability to effectively prepare students for the complexities of modern military medicine.<b>Methods:</b> A qualitative approach was employed, consisting of focused group discussions (FGDs) with six students and six faculty members. Data were analyzed using MAXQDA 24 to identify recurring themes related to curriculum content, instructional methods, and the effectiveness of practical training in military medicine.<b>Results:</b> The findings reveal that while DSMA offers a broad curriculum, practical training and its real-world application are insufficient. Key recommendations include revising the curriculum to include modern warfare medicine, expanding hands-on training experiences, and incorporating innovative teaching methods such as mobile training platforms. Additional strategies include using high-fidelity simulations, restructuring the curriculum to enhance its relevance, and establishing a dedicated department for military medicine.<b>Conclusion:</b> This research identifies critical gaps in DSMA’s curriculum, particularly in practical training, that need to be addressed to better prepare graduates for contemporary military and civilian healthcare demands. Implementing the recommended improvements will ensure that DSMA graduates are equipped to meet modern healthcare challenges and maintain the academy’s leadership in military medical education.
DOI: 10.6084/m9.figshare.27979727.v1
title: Supplementary Material for: Examining Negativity Biases in Facial Emotion Reactions in Young Persons First-Presenting with Borderline Personality Disorder

description: Introduction: Individuals with borderline personality disorder (BPD) are thought to experience specific biosocial vulnerabilities that give rise to a maladaptive negativity bias in the perception and expression of emotions. However, while this negative bias has been identified in adults with full threshold BPD or high BPD features, it is unclear whether it is evident earlier in the course of the disorder—that being, young persons with first presentation BPD meeting three or more BPD features, as defined by early intervention models. Methods: The current study compared patterns of facial responding in individuals aged 15-25 first presenting to a specialist outpatient service with three or more BPD features (n = 32) to age-matched healthy controls (n = 46). Facial electromyography was used to assess muscle activity associated with positive (zygomaticus major) and negative (corrugator supercilii) expression while participants viewed happy, angry, and neutral facial expressions. Results: The data revealed that negative facial emotional reactivity for the BPD group did not significantly differ from the control group. However, the results for positive emotional reactivity were more nuanced, indicating that while there was not an overall between group difference, there might be an effect of time suggestive of a slower positive emotional reaction to happy faces by the BPD group. Conclusions: These data provide initial evidence that negatively biased emotional expression, when responding with negative facial expressions to neutral, happy or angry faces, is not evident in young persons first-presenting to a specialist outpatient service for treatment of BPD. However, a bias may be demonstrated by what appears to be a slower positive affective response to happy faces. The implications of these findings are discussed, particularly in relation to factors associated with chronicity of illness that might potentially contribute to the development of a more pronounced negativity bias later in the course of the illness. We encourage further examination of negativity biases in the developmental sequelae of BPD via longitudinal design or cross-sectional designs that include BPD participants across the course of illness, as well as further research to explore the possibility that positive affective reactions in this group might not be grossly blunted, but rather delayed.
DOI: 10.6084/m9.figshare.28692515.v6
title: <b>Molecular mechanism of phenol 2-monooxygenase (FgPhm)</b><b>in regulating virulence and DON biosynthesis in </b><b><i>Fusarium graminearum</i></b>

description: this study has demonstrated that FgPhm1 is crucial for the growth and development of F. graminearum and the production of Deoxynivalenol (DON), and plays an important role in the pathogenicity and stress response processes of F. graminearum. Through depth research on phenol2-monooxygenase, it lays a foundation for fundamentally revealing the mechanism of action of phenol2-monooxygenase during the growth and development process of F. graminearum, and reveals the relationship between phenol metabolism and the pathogenic mechanism in F. graminearum. Thiswill provides a theoretical basis for the development of new pesticides and the prevention and control of Fusarium head blight of wheat.
DOI: 10.6084/m9.figshare.28789433.v1
title: Data S1. Supplementary Figures_vFinal_clean.docx

description: Radiation therapy causes long-term skeletal muscle atrophy and fibrosis in juvenile cancer survivors. The mechanisms responsible for the skeletal muscle late effects of radiation therapy are not well-understood and have prevented the development of effective treatments. Using single-cell RNA sequencing (scRNA-seq), we characterize cellular dynamics and communication in a murine model of therapeutic radiation at 24-hours and 56-days post-irradiation (post-IR).<b> </b>We detected changes in muscle stem (satellite) cells (MuSCs) characterized by an acute preservation of committed MuSCs and long-term relative depletion of deep quiescent MuSCs. A conserved senescence <i>Cdkn1a</i> signature was observed in all muscle-resident cells post-IR. Genes related to fibroblast proliferation were up-regulated and a fibrotic and senescent transcriptome persisted in Fibro-adipogenic progenitors (FAPs) post-IR. Intercellular communication analysis revealed FAPs as the primary contributor of extracellular matrix (ECM) and target of monocyte/macrophage-derived TGF-β signalling post-IR through TGF-βR2 on FAPs. Together, our findings provide insights into the potential mechanisms and intercellular communication responsible for radiation-induced muscle atrophy and fibrosis.
DOI: 10.6084/m9.figshare.5634754
title: The limitations of the electric-field model of the conductor and its didactical implications

description: We study a classical electrostatic problem presented in highschool and university textbooks: the electric field generated by a charge excess in a spheric conductor. Firstly, we verify the field value on the surface of the conductor, assuming the singular charge distribution model. Secondly, given some flexibility to the charge distribution to a uniform density over a tiny spherical shell, we show that apparent discrepancies that are presented in literature only give evidence of the limitations of the singular model on describing of the real object.
DOI: 10.6084/m9.figshare.7448018.v1
title: Manual laterality in action's coding strategies.xlsx

description: Raw data of an experiment presenting two objects (chestnut burr and apricot), with participants sorting out object's color while wearing gloves or not. Stimuli appeared on the right or left side of a computer screen and participants responded with their left or right hand. <br>Be careful, accuracy=0 for correct responses while accuracy=1 for errors.<br>For more details see "Grasping a chestnut burr: manual laterality in action's coding strategies", Michalland, Thébault, Briglia, Fraisse, Brouillet<br><br>
DOI: 10.6084/m9.figshare.7609160.v1
title: 25 venom expression signatures

description: 25 differential expression signatures generated for human IMR-32 cells exposed to dilute crude venoms. Signatures were made using DESeq2 with an FDR-corrected p-value threshold of 0.10. Gene names are represented using HUGO nomenclature.
DOI: 10.6084/m9.figshare.25336900.v1
title: Data for "Empirical stream thermal sensitivity cluster on the landscape according to geology and climate"

description: Climate change is modifying river temperature regimes across the world. To apply management interventions in an effective and efficient fashion, it is critical to both understand the underlying processes causing stream warming and identify the streams most and least sensitive to environmental change. Empirical stream thermal sensitivity, defined as the change in water temperature with a single degree change in air temperature, is a useful tool to characterize historical stream temperature conditions and to predict how streams might respond to future climate warming. We measured air and stream temperature across the Snoqualmie and Wenatchee basins, Washington, during the hydrologic years 2015–2021. We used ordinary least squares regression to calculate seasonal summary metrics of thermal sensitivity and time-varying coefficient models to derive continuous estimates of thermal sensitivity for each site. We then applied classification approaches to determine unique thermal sensitivity regimes and, further, to establish a link between environmental covariates and thermal sensitivity regimes. We found a diversity of thermal sensitivity responses across our basins that differed in both timing and magnitude of sensitivity. We also found that covariates describing underlying geology and snowmelt were the most important in differentiating clusters. Our findings and our approach can be used to inform strategies for river basin restoration and conservation in the context of climate change, such as identifying climate-insensitive areas of the basin that should be preserved and protected.
DOI: 10.6084/m9.figshare.11620104.v1
title: MENDH-Thermo-annotations

description: Functional annotations of MENDH-Thermo MAG
DOI: 10.6084/m9.figshare.11828454.v1
title: Simulated mean wave direction (3-hourly, 150a) from FIO-ESM v2.0 1pctCO2 experiment r1i1p1f1

description: Simulated mean wave direction (3-hourly, 150a) from FIO-ESM v2.0 1pctCO2 experiment (CO2 prescribed to increase at 1% per year) r1i1p1f1, which is branch from Jan 1, 301 of piControl experiment. The grid, named gx1v6, is the displaced pole (the North Pole displaced to the Greenland) grid with 1.1 degree in longitude and 0.27-0.54 degree in latitude.
DOI: 10.6084/m9.figshare.21760976.v2
title: MethylSeq bismark coverage files test data

description: - small test dataset for testing methylkit, bismark-produced coverage files <br>
DOI: 10.6084/m9.figshare.23666253.v1
title: Supplementary Material for: Conversion From Intermittent Hemodialysis to Peritoneal dialysis in metastatic Catheter-Related Blood Stream Infection

description: Of all complications from Central Venous Catheters (CVC) in End-Stage Renal Disease [ESRD] patients, Catheter-Related Blood Stream Infection [CRBSI] is one of the most devastating consequences. The option of catheter salvage is not an effective measure with metastatic infections. However, in patients with severe vasculopathy and/or near end-stage vascular disease, preservation of the venous access should be given utmost importance as the luxury of utilizing another vascular site is markedly limited. Providing adequate renal replacement therapy in this group of patients can be remarkably challenging for Nephrologists. We are presenting an ESRD patient with advanced vascular disease who developed metastatic catheter-related bloodstream infection (CRBSI) with worsening uremia who was successfully converted from Intermittent hemodialysis [IHD] to Peritoneal dialysis [P.D]. Our rationale was to minimize repeated intravascular procedures coupled with the presence of another intravascular device. This has led to a complete resolution of persistent bacteremia, with a steady improvement in the uremic state. Conversion from IHD to PD for persistent bacteremia with metastatic complications was seldom addressed in literature. In the absence of a significant contraindication to PD, it can be considered as a valid alternative possibility in order to interrupt this viscous cycle especially in vasculopathic patients.
DOI: 10.6084/m9.figshare.8987060.v1
title: Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica

description: The present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg.
DOI: 10.6084/m9.figshare.28603568.v1
title: Industry Practitioner Safety Resilience Common Factors Survey(DATA)

description: Survey data
DOI: 10.6084/m9.figshare.26392783.v1
title: <b>Screening diagnostic biomarkers for autism spectrum disorder using plasma proteomics combined with machine learning methods</b>

description: Background and aims: Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder in children. Currently, the pathogenesis of ASD has not been elucidated, and there are no specific therapeutic agents, but early detection and intervention can be effective. To discover biomarkers that can provide clinicians with diagnostic aids. Materials and Methods: We conducted a sequential window acquisition of all theoretical spectra-mass spectrometry (SWATH-MS)-based plasma proteomics study between ASD children and controls., 30 DSM-V defined ASD cases vs. age and sex-matched controls were initially evaluated by SWATH-MS and the findings followed-up by MRM analyses using an independent group of 30 ASD cases vs. controls. Ccombined with machine learning analysis to screen potential biomarkers and applied multiple reaction monitoring (MRM) technology to target and validate candidate biomarkers. Results: Fifty-one differentially expressed proteins (DEPs) were identified by SWATH analysis between cases and controls, and they were mainly associated with immune response, complements and coagulation cascade pathways, and apolipoprotein-related metabolic pathways, which have been reported in previous studies. Machine learning analysis screened 10 proteins as biomarker combinations (TFRC, PPBP, APCS, ALDH1A1, CD5L, SPARC, FGG, SHBG, S100A9, and PF4V1). In MRM targeted analysis, 4 proteins (PPBP, APCS, FGG, and PF4V1) were found to be significantly different between groups and had high diagnostic values as a combination of diagnostic markers for ASD (AUC=0.8087, 95% confidence interval, 0.6904-0.9252, p &lt; 0.0001). Conclusions: This study provides new insights into the mechanisms and blood diagnostic markers of ASD.
DOI: 10.6084/m9.figshare.7857857.v1
title: Mus musculus C3H/HeJ CasX sites

description: This is an annotated list of potential CasX (Cas12e) editing sites based on Ensembl Release 95 for <i>Mus musculus C3H/HeJ</i>. The sites are annotated with location contig, start, end, target sequence, PAM sequence, uniqueness among editing sites, and overlaps with known exons.
DOI: 10.6084/m9.figshare.12081144.v1
title: PanSTARRS DR1 Broad Morphology Catalog

description: This is a broad morphology (spiral or elliptical) catalog of images identified as galaxies from the first data release of PanSTARRS (PS1 DR1). Annotations were produced by a deep neural network based on the LeNet-5 architecture, and training labels were obtained using "superclean" Galaxy Zoo annotations.<br>The catalog contains labels for 1,662,190 images and has approximately 95% overall accuracy. The dataset is a csv file (with headers) containing the following columns:<b>objid</b> (string): The object ID of the image assigned by PanSTARRS.<b>ra</b> (float): The object's right ascension.<b>dec</b> (float): The object's declination.<b>prob_sp</b> (float): The probability of the galaxy being spiral.<b>prob_el</b> (float): The probability of the galaxy being elliptical.<b>spiral</b> (integer): If prob_sp is greater than prob_el, this is 1; otherwise, it is 0.<b>elliptical</b> (integer): If prob_el is greater than prob_sp, this is 1; otherwise, it is 0.
DOI: 10.6084/m9.figshare.3369790.v1
title: Pacing during an ultramarathon running event in hilly terrain

description: <b>Purpose.</b> The dynamics of speed selection as a function of distance, or pacing, are used in recreational, competitive, and scientific research situations as an indirect measure of the psycho-physiological status of an individual. The purpose of this study was to determine pacing on level, uphill and downhill sections of participants in a long (~173 km) ultramarathon performed on trails in hilly terrain. <b>Methods.</b> Fifteen ultramarathon runners competed in a ~173 km event (five finished at ~103 km) carrying a Global-Positioning System (GPS) device. Using the GPS data, we determined the speed, relative to average total speed, in level (LEV), uphill (UH) and downhill (DH) gradient categories as a function of total distance, as well as the correlation between overall performance and speed variability, speed loss, and total time stopped. <b>Results.</b> There were no significant differences in normality, variances or means in the relative speed in 173-km and 103-km participants. Relative speed decreased in LEV, UH and DH. The main component of speed loss occurred between 5% and 50% of the event distance in LEV, and between 5% and 95% in UH and DH. There were no significant correlations between overall performance and speed loss, the variability of speed, or total time stopped. <b>Conclusions.</b> Positive pacing was observed at all gradients, with the main component of speed loss occurring earlier (mixed pacing) in LEV compared to UH and DH. A speed reserve (increased speed in the last section) was observed in LEV and UH. The decrease in speed and variability of speed were more important in LEV and DH than in UH. The absence of a significant correlation between overall performance and descriptors of pacing is novel and indicates that pacing in ultramarathons in trails and hilly terrain differs to other types of running events.
DOI: 10.6084/m9.figshare.5531116.v5
title: My medication education data

description: A national representative sample of 6,226 students from 99 primary, middle, and high schools completed an online self-administered questionnaire. Multiple logistic regression analysis was used to examine factors related to inappropriate self-medication.
DOI: 10.6084/m9.figshare.7745735.v1
title: Supplementary Material for: Adherence to Kidney Disease: Improving Global Outcomes Mineral and Bone Guidelines for Monitoring Biochemical Parameters

description: <b><i>Background:</i></b> Mineral and bone disorder (MBD) is common in patients with chronic kidney disease (CKD), and is associated with risk of fractures, cardiovascular disease, and death. Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend monitoring CKD-MBD biochemical markers, including parathyroid hormone (PTH), phosphorus, 25-hydroxyvitamin D (25D), calcium, and alkaline phosphatase (ALP), in patients with moderate-to-severe CKD. <b><i>Methods:</i></b> To determine guideline adherence, we used administrative claims records from the 20% sample of Medicare beneficiaries with Parts A, B, and D coverage, 2007 to 2015, and identified cohorts of patients with nondialysis stage 3, 4, or 5 CKD. Testing for biochemical markers during follow-up was defined based on laboratory procedure codes. Baseline factors associated with laboratory testing were determined using logistic regression. All analyses were performed separately by CKD stage. <b><i>Results:</i></b> A total of 640,946 stage 3, 136,278 stage 4, and 22,076 stage 5 CKD patients, 50.2–52.9% women, mean age 74.4–78.0 years, were followed for a mean of 2.5, 1.3, and 0.7 years respectively. The frequency of testing was low for PTH (35.2–48.2%), phosphorus (46.6–62.0%), and 25D (29.3–46.7%). Testing was somewhat higher for calcium (88.1–95.4%) and ALP (63.5–88.1%); most tests were features of larger panels (e.g., basic metabolic panel). Older age, most comorbid conditions, and lack of prior nephrology care were associated with lower likelihood of testing. <b><i>Conclusions:</i></b> In fee-for-service Medicare beneficiaries, laboratory testing for CKD-MBD biochemical markers appears to be suboptimal in relation to KDIGO guidelines. Competing priories, such as management of comorbid disease and preparation for renal replacement therapy, may distract from CKD-MBD monitoring.