cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14762991.v4
title: Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the potential mechanism of action of miltefosine

description: <i>Aspergillus fumigatus</i> is an important fungal pathogen and the main etiological agent of aspergillosis, a disease characterized by a noninvasive process that can evolve to a more severe clinical manifestation called invasive pulmonary aspergillosis (IPA) in immunocompromised patients. The antifungal arsenal to threat aspergillosis is very restricted. Azoles are the main therapeutic approach to control IPA, but the emergence of azole-resistant <i>A. fumigatus </i>isolates has significantly increased over the last decades. Therefore, new strategies are necessary to combat aspergillosis and drug repurposing has emerged as an efficient and alternative approach for identifying new antifungal drugs. Here, we used a screening approach to analyze <i>A. fumigatus</i> in vitro susceptibility to 1,127 compounds. <i>A. fumigatus</i> was susceptible to 10 compounds, including miltefosine, a drug that displayed fungicidal activity against <i>A. fumigatus</i>. By screening an <i>A. fumigatus</i> transcription factor null library, we identified a single mutant, which has the <i>smiA</i> (<i>s</i>ensitivity to <i>m</i>iltefosine) gene deleted, conferring a phenotype of susceptibility to miltefosine. The transcriptional profiling (RNA-seq) of the wild-type and the Δ<i>smiA</i> strains and the Chromatin Immunoprecipitation coupled to next generation sequencing (ChIP-Seq) of a SmiA-tagged strain exposed to miltefosine revealed genes of the sphingolipids pathway that are directly or indirectly regulated by SmiA. Sphingolipids analysis demonstrated that the mutant has overall decreased levels of sphingolipids when growing in the presence of miltefosine. The identification of SmiA represents the first genetic element described and characterized which plays a direct role in miltefosine response in fungi.<b><br> </b>
DOI: 10.6084/m9.figshare.25669473.v1
title: collocates of deictic verbs

description: This file includes tables of each deictic verb with its collocates including statistical measures such as MI, t-score, and logDice.
DOI: 10.6084/m9.figshare.5353486.v1
title: Horse data Plos One 2017.xlsx

description: This data file accompanies the Plos One publication:Low plasma cortisol and fecal cortisol metabolite measures as indicators of compromised welfare in domestic horses (<i>Equus caballus</i>) Jodi Pawluski<sup>1*</sup>, Patrick Jego<sup>2</sup>, Séverine Henry<sup>2</sup>, Anaelle Bruchet<sup>2</sup>, Rupert Palme<sup>3</sup>, Caroline Coste<sup>2</sup>, & Martine Hausberger<sup>4*</sup> <sup> </sup> <sup>1 </sup>Institut de recherche en santé, environnement et travail (Irset), U1085 INSERM, Université de Rennes 1, Rennes, France <sup>2 </sup>Université de Rennes 1, UMR 6552 CNRS Ethologie Animale et Humaine, Station Biologique de Paimpont, France <sup>3</sup>University of Veterinary Medicine, Department of Biomedical Sciences, Vienna, Austria <sup>4</sup>CNRS, UMR 6552 Ethologie animale et humaine, Université de Rennes 1, Rennes, France *Corresponding authors Email : j.pawluski@gmail.com/jodi-lynn.pawluski@univ-rennes1.fr Email : martine.hausberger@univ-rennes1.fr
DOI: 10.6084/m9.figshare.7982858.v1
title: LC-QuAD 2.0

description: question answering<br>
DOI: 10.5281/zenodo.15315691
title: Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial.

description: The dataset refers to the results of the Efficacy of Multiple Nonpharmacological Interventions - E.Mu.N.I. - study, published in the paper 'Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial.' by Rolandi et al. Aging Clin Exp Res 2025. The dataset is publicly available.
DOI: 10.5281/zenodo.15315692
title: Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial.

description: The dataset refers to the results of the Efficacy of Multiple Nonpharmacological Interventions - E.Mu.N.I. - study, published in the paper 'Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial.' by Rolandi et al. Aging Clin Exp Res 2025. The dataset is publicly available.
DOI: 10.6084/m9.figshare.27619872.v1
title: Supplementary Material for: Gender-specific differences in recurrence and progression following BCG instillation for NMIBC

description: Introduction: To assess gender-specific differences in recurrence-free (RFS), progression-free (PFS), cancer-specific survival (CSS) and overall survival (OS) among patients with intermediate or high-risk non-muscle invasive bladder cancer (NMIBC) receiving BCG is the primary aim of this systematic review and meta-analysis.
Methods: In July 2023, we performed a literature search using MEDLINE, Embase and Cochrane Library. This study was prospectively registered at PROSPERO (CRD 2023443269). The detailed review protocol is accessible via CRD. 
Results: The systematic literature search identified 6,723 studies, of which 38 fulfilled the inclusion criteria. Random effect meta-analysis for RFS, based on data from 24 studies, revealed no statistically significant gender-specific difference (HR comparing males to females=0.9618, 95% CI: 0.8408-1.1003, p=0.5707). Similarly, for PFS, incorporating data from 14 studies, no statistically significant difference (HR =0.9540, 95% CI: 0.7709- 1.1805, p=0.6648), for CSS, analysis of data from three studies yielded no statistically significant difference (HR =0.9228, 95% CI: 0.6196-1.3743, p=0.6925), and for OS, based on data from two studies, no statistically significant difference was observed (HR = 1.1436, 95% CI: 0.5092-2.5684, p=0.7452). The risk of bias assessment indicated an overall moderate to high risk of bias.
Conclusion: The findings indicate no association between gender and oncologic outcomes following BCG.
DOI: 10.6084/m9.figshare.28801157.v2
title: <b><i>Single electrically induced epileptic afterdischarge triggers synaptic weakening, AMPA receptor endocytosis and shrinkage of dendritic spines in the hippocampus</i></b>

description: Dataset of the manuscript entitled '<i>Single electrically induced epileptic afterdischarge triggers synaptic weakening, AMPA receptor endocytosis and shrinkage of dendritic spines in the hippocampus</i><br>
DOI: 10.6084/m9.figshare.1613282.v1
title: Daims ENR6 metagenome dataset

description: R formated metagenome dataset.
DOI: 10.6084/m9.figshare.8313605.v2
title: ACASS Motion Capture Data (N = 396)

description: This database accompanies the rticle "Introducing ACASS: An Annotated Character Animation Stimulus Set for Controlled (e)Motion Perception Studies" (doi.org/10.3389/frobt.2019.00094).<br>It contains 396 FBX-files and one text-file (TXT-file) explaining the structure of the filenames.<br><br>Please refer to the original article for further information.<br>
DOI: 10.6084/m9.figshare.5572774.v1
title: Interactome data

description: Interactome used for doing PPI based analysis
DOI: 10.6084/m9.figshare.11369355.v5
title: Turkish General Elections 2002-2018

description: Simulated results of the 2002 to 2018 Turkish elections with the threshold, malapportionment, and the threshold and malapportionment combined removed. The Gallagher Index is used to assess the proportionality of each simulation and is compared to the Gallagher Index of the actual result of each election.
DOI: 10.6084/m9.figshare.28491086.v1
title: <b>ASSESSMENT OF THE PERFORMANCE OF VARIOUS HYBRID MAIZE (</b><b><i>Zea mays </i></b><b>L.) VARIETIES DURING SPRING SEASON IN DHADING, NEPAL</b>

description: This research was conducted on Dhading, Nepal to identify superior hybrid genotypes of maize. The genotypes were evaluated in a randomized complete block design with three replications. They were sampled for different traits such as days to 50% plant emergence, plant height, days to 50% plant tasseling, days to 50% silking, anthesis-silking interval, cob height, leaf number below the main cob, leaf number above the main cob, stem girth, number of cobs per plant, cob length, cob girth, number of kernel row per cob, number of kernels per row, thousand kernel weight and grain yield. Among the 7, C.P.808 and Rampur Hybrid-10 are found to be better in yield and yield attributing characters.
DOI: 10.6084/m9.figshare.23726856.v1
title: Supplementary Material for: Health economic aspects of platelet concentrates – comparing cost and reimbursement of pathogen inactivated and conventional platelet concentrates in a German comprehensive cancer center.

description: INTRODUCTION Pathogen inactivation (PI) utilizing Amotosalen and UVA light (INTERCEPT® Blood System) is a well-established method for the production of safer platelet concentrates (PC). While many studies describe clinical and logistical benefits of PI, the implications and potential challenges from a hospital management perspective have not yet been analyzed - health economic analyses considering reimbursement of PI are lacking. The objective of this analysis was to examine the real-life inpatient treatment costs from a hospital perspective and to assess the economic impact of PI-PC versus conventional PC (CONV-PC) administration in Germany. METHODS Real-life cost data for inpatient cancer cases from 2020 of the University Hospital Cologne were identified by operating and procedure codes (OPS). The German diagnosis-related groups (G-DRG), extra fees, case mix index (CMI), length of stay (LOS), and average resource consumption of PC were evaluated from a micro-management perspective. The potential economic impact of implementing PI-treated PCs was modelled retrospectively. RESULTS In total, 951 inpatient cases were analyzed (CMI [median 4.7 - 9.9], LOS [median 26 days], number of cases in intensive care units [38%]). The median DRG fee was between EUR 13,800 and EUR 26,400. According to our model, the use of PI-PC compared to CONV-PC would result in savings between EUR 184 and EUR 306 per case. DISCUSSION / CONCLUSION From a hospital management perspective, oncological cases requiring PC transfusion are associated with a high CMI (reimbursement per DRG flat fee) and moderate costs with sufficient add-on payment for PI on a case level. Investment and process costs for PI implementation can be analyzed for site-specific scenarios.
DOI: 10.6084/m9.figshare.26879036.v1
title: SNPs of 10 populations of Macrobrachium rosenbergii

description: Mutation detection was performed on 198 individuals of 10 populations of <i>Macrobrachium rosenbergii</i>. A total of 300, 828 high-quality SNP loci were obtained after filtering.
DOI: 10.6084/m9.figshare.16715383.v1
title: Supplementary Material for: GPR43 suppresses intestinal tumor growth by modification of the mammalian target of rapamycin complex 1 activity in ApcMin/+ mice

description: Medicine
DOI: 10.21942/uva.26212940.v1
title: Behavioral data

description: Behavioral data for the manuscript: "Pharmacological elevation of catecholamine levels improves perceptual decisions, but not metacognitive insight"The file contains trial-wise information about, among others:presented stimulus (0: CW or 1: CCW)behavioral response (0: CW or 1: CCW)confidence rating (0: low confidence or 1: high confidence)RTDrugBaseline pupil size (and bin)
DOI: 10.17028/rd.lboro.28890251
title: Semi-structured interviews with adolescents (10-15YO) and their parents/carers/guardians about eating and body weight

description: We conducted semi-structured interviews with 16 adolescents (10-15-years-old) and their parents/carers/guardians exploring what messages they hear about eating and body weight from various sources in their lives (e.g., family, peers, school, social media); this included a scenario-building task. Semi-structured interviews were audio-recorded and transcribed for analysis. Depending on the medium chosen for their scenario-building (Dictated drawing or Lego), photographs of Lego outputs were taken and images created from dictated drawings using Canva.
DOI: 10.17028/rd.lboro.28890251.v1
title: Semi-structured interviews with adolescents (10-15YO) and their parents/carers/guardians about eating and body weight

description: We conducted semi-structured interviews with 16 adolescents (10-15-years-old) and their parents/carers/guardians exploring what messages they hear about eating and body weight from various sources in their lives (e.g., family, peers, school, social media); this included a scenario-building task. Semi-structured interviews were audio-recorded and transcribed for analysis. Depending on the medium chosen for their scenario-building (Dictated drawing or Lego), photographs of Lego outputs were taken and images created from dictated drawings using Canva.
DOI: 10.6084/m9.figshare.20300727.v1
title: Supplementary Material for: Cinnamon Infusion Reduces Satiety and Increases Energy Intake: A Randomized Crossover Trial

description: Background/Aims: This study aimed to evaluate the effects of the intake of a single dose of cinnamon infusion on energy metabolism, appetite responses and food intake in healthy individuals. Methods: This was an open randomized crossover clinical trial, with a minimum washout of seven days, which was conducted in which two standardized breakfasts were served randomly: one with cinnamon infusion (2g, Cinnamomum sp.) And one with water (control). The study included 21 healthy volunteers. Energy expenditure (EE), diet-induced thermogenesis (DIT), respiratory quotient (RQ), substrate oxidation and appetite responses were evaluated, as well as prospective food intake. Results: Ingestion of cinnamon infusion did not alter EE, DIT, RQ or substrate oxidation. The incremental area under the curve for hunger, satiety and desire to eat did not differ between the treatment with cinnamon infusion and water, however, there was a reduction in the feeling of satiety (p=0.021) compared to the control treatment. The energy consumption of the first meal after treatment was higher (p=0.05) in the treatment with cinnamon infusion than in the control treatment. Regarding macronutrients or food intake throughout the day, there was no difference between treatments. Conclusions: Although it did not affect energy metabolism, consuming a single dose of cinnamon infusion promoted less feeling of satiety and increased energy intake in the first meal after treatment. The study protocol was registered at the Brazilian Clinical Trials Registry Platform (RBR-5ftg3z).
DOI: 10.15468/dl.bav7fx
title: Occurrence Download

description: A dataset containing 18934 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Trogidae"
 ]
}

 The dataset includes 18934 records from 295 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0176564-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.22144736.v1
title: Nisin Lantibiotic Prevents Liver Steatosis and Mitochondrial Oxidative Stress following Polymicrobial-Periodontal Infection by Abrogating Oral and Gut Dysbiosis and Hepatic Exposure to Bacterial Load

description: Data are from a study examining the preventive effect of nisin on periodontal disease-related gut dysbiosis and non-alcoholic fatty liver disease, including results from several DNA and RNA sequencing, biochemical, and histological analyses.
DOI: 10.6084/m9.figshare.25057613.v1
title: Base datos_Bursera_Barrales y Bonfíl.xlsx

description: Base de datos "Análisis del conocimiento actual de la ecología, evolución y manejo del género Bursera en México"
DOI: 10.6084/m9.figshare.26787523.v1
title: Supplementary Material for: Impact of diabetes mellitus and obesity comorbidities on survival outcomes after hepatocellular carcinoma resection: A multicenter retrospective study

description: Introduction: This study aimed to evaluate the association of obesity and diabetes mellitus (DM) comorbidity with hepatocellular carcinoma (HCC) recurrence and survival.
Methods: We investigated 1,644 patients who underwent hepatic resection for solitary HCC without vascular invasion using computed tomography. Patients were categorized into four groups according to the combination of obesity and DM comorbidities: OB (+) or (−) and DM (+) or (−).Postoperative cumulative recurrence rates within and beyond 2 years and beyond 5 years were assessed.
Results: Multivariate Cox proportional hazard regression analysis revealed that the adjusted hazard ratios (HRs) of reduced recurrence-free survival was 1.10 (95% confidence interval [CI]: 0.91–1.33; p = 0.31), 0.94 (95% CI: 0.78–1.12; p = 0.48), and 1.24 (95% CI: 1.01–1.54; p = 0.045) in the OB(+)DM(−), OB(−)DM(+), and OB(+)DM(+) groups compared with the OB(−)DM(−) group, respectively. Additionally, the corresponding adjusted HRs of reduced overall survival were 0.93 (p = 0.57), 0.97 (p = 0.76), and 1.38 (p = 0.013) for OB(+)DM(−), OB(−)DM(+), and OB(+)DM(+) groups, respectively. No significant difference in the early recurrence rate was determined among the four groups. The OB(+)DM(+) group demonstrated an increased risk for late recurrence beyond 2 years and 5 years postoperatively compared with the OB(−)DM(−) group (HR: 1.51; p = 0.024 and HR: 2.53; p = 0.046, respectively). The OB(+)DM(−) and OB(−)DM(+) groups demonstrated an increased risk for late recurrence beyond 5 years postoperatively (HR: 3.83; p &lt; 0.001 and HR: 1.95; p = 0.037, respectively).
Conclusions: Obesity and DM coexistence increased late recurrence and worsened prognosis in patients with HCC undergoing hepatic resection. The results help surgeons develop possible different surveillance protocol and need to focus on diabetes/obesity control during life-long surveillance for patients with HCC.
DOI: 10.6084/m9.figshare.8980541.v1
title: Photos of the sites

description: Photos of some of the sites included in Globe-LFMC
DOI: 10.6084/m9.figshare.1011782.v1
title: Linear loss rates (% loss rates in parentheses) of DOM (<em>a</em><sub>320</sub> and four EEMs components) over the first four days of incubation as a function of time (bold means regression <em>p</em>-values

description: <b>Table 3.</b> Linear loss rates (% loss rates in parentheses) of DOM (<em>a</em><sub>320</sub> and four EEMs components) over the first four days of incubation as a function of time (bold means regression <em>p</em>-values <strong>Abstract</strong> The abundant thaw lakes and ponds in the circumarctic receive a new pool of organic carbon as permafrost peat soils degrade, which can be exposed to significant irradiance that potentially increases as climate warms and ice cover shortens. Exposure to sunlight is known to accelerate the transformation of dissolved organic matter (DOM) into molecules that can be more readily used by microbes. We sampled the water from two common classes of ponds found in the ice-wedge system of continuous permafrost regions of Canada, polygonal and runnel ponds, and followed the transformation of DOM over 12 days by looking at dissolved organic carbon (DOC) concentration and DOM absorption and fluorescence properties. The results indicate a relatively fast decay of color (3.4 and 1.6% loss d<sup>−1</sup> of absorption at 320 nm for the polygonal and runnel pond, respectively) and fluorescence (6.1 and 8.3% loss d<sup>−1</sup> of total fluorescent components, respectively) at the pond surface, faster in the case of humic-like components, but insignificant losses of DOC over the observed period. This result indicates that direct DOM mineralization (photochemical production of CO<sub>2</sub>) is apparently minor in thaw ponds compared to the photochemical transformation of DOM into less chromophoric and likely more labile molecules with a greater potential for microbial mineralization. Therefore, DOM photolysis in arctic thaw ponds can be considered as a catalytic mechanism, accelerating the microbial turnover of mobilized organic matter from thawing permafrost and the production of greenhouse gases, especially in the most shallow ponds. Under a warming climate, this mechanism will intensify as summers lengthen.
DOI: 10.6084/m9.figshare.8797100.v1
title: MS-275 Chemical Analogues Promote Hemoglobin Production and Erythroid Differentiation of K562 Cells

description: β-Thalassemia (β-thal) is a hemoglobinopathy characterized by reduced or absent β-globin production. Pharmacological reactivation of the γ-globin gene for the production of fetal hemoglobin (Hb F) presents an attractive treatment strategy. In an effort to identify promising therapeutic agents, we evaluated 80 analogues of the histone deacetylase inhibitor MS-275, a known Hb F inducer. The chemical analogues were identified <i>via</i> molecular modeling and targeted chemical modifications. Nine novel agents exhibited significant hemoglobin (Hb)-inducing and erythroid differentiation activities in the human K562 erythroleukemia cell line. Five of them appeared to be stronger inducers than the lead compound, MS-275, demonstrating the effectiveness of our method.
DOI: 10.6084/m9.figshare.17085842.v1
title: Supplementary Material for: Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease

description: <b><i>Background:</i></b> Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease and is well known to have extrarenal complications. Cardiovascular complications are of particular clinical relevance because of their morbidity and mortality; however, unclear is why they occur so frequently in patients with ADPKD and whether they are related to the genotypes. <b><i>Methods:</i></b> We extracted and retrospectively analyzed clinical data on patients with ADPKD who underwent echocardiography and whose genotype was confirmed by genetic testing between April 2016 and December 2020. We used next-generation sequencing to compare cardiac function, structural data, and the presence of cardiac valvular disease in patients with 1 of 3 genotypes: <i>PKD1</i>, <i>PKD2</i>, and non-<i>PKD1</i>, <i>2</i>. <b><i>Results:</i></b> This retrospective study included 65 patients with ADPKD. Patients were divided into 3 groups: <i>PKD1</i>, <i>n</i> = 32; <i>PKD2</i>, <i>n</i> = 12; and non-<i>PKD1</i>, <i>2</i>, <i>n</i> = 21. The prevalence of mitral regurgitation (MR) was significantly higher in the <i>PKD1</i> group than in the <i>PKD2</i> and non-<i>PKD1</i>, <i>2</i> group (46.9% vs. 8.3% vs. 19.0%, respectively; <i>p</i> = 0.02). In contrast, no significant difference was found for other cardiac valve complications. <b><i>Conclusion:</i></b> This study found a significantly higher prevalence of MR in patients with the <i>PKD1</i> genotype than in those with the <i>PKD2</i> or non-<i>PKD1</i>, <i>2</i> genotypes. Physicians may need to perform echocardiography earlier and more frequently in patients with ADPKD and the <i>PKD1</i> genotype and to control fluid volume and blood pressure more strictly in these patients to prevent future cardiac events.
DOI: 10.6084/m9.figshare.9810170.v1
title: LPG Paper Data Sets

description: 1. The appended data set of the two waves of ACCESS survey from 2014-15 and 2018 for panel data analysis.2. The merged data set of the two waves of ACCESS survey from 2014-15 and 2018 for cross-sectional data analysis.
DOI: 10.6084/m9.figshare.936924.v1
title: Data and code for "The lifespan development of cognate guessing skills in an unknown related language"

description: The data and R code for <strong>Jan Vanhove & Raphael Berthele, The lifespan development of cognate guessing skills in an unknown related language</strong> (forthcoming in <em>IRAL</em>). Feel free to reproduce our analyses or carry out your own analyses on these data, but please cite them or our paper appropriately when publishing your analyses. Please note that the software used for the analyses (described in the paper) is in constant development and that later program versions may yield (slightly) different results. Should you spot any errors in these analyses, please let us know!