cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17044/scilifelab.30009196.v1
title: Ultrasound-guided, magnetothermal wax capsule for localized gastrointestinal drug delivery

description: Oral drug delivery to specific lesions in the gastrointestinal (GI) tract remains a major challenge. The current systems depend on internal physiological triggers such as pH, enzymatic activity, and luminal pressure, which exhibit wide intra- and inter-patient variability. To address this, an ingestible capsule was developed to enable on-demand, site-specific drug release in response to an external alternating magnetic field (AMF), with ultrasound imaging used for real-time localization. The capsule is composed of a low-melting-point wax matrix embedded with superparamagnetic iron oxide nanoparticles (SPIONs), which generate heat upon AMF exposure, resulting in rapid wax melting and burst drug release. SPIONs exhibited no toxicity in zebrafish embryonic development, demonstrating excellent biocompatibility. Capsules were fabricated in a hemispherical shape using a 3D-printed mold, yielding highly reproducible batches with a mass variation within ±10%. A Design of Experiments (DoE) approach identified an optimized formulation comprising a 6:4 docosane:eicosane wax blend, 10 wt% SPION loading, and a 1.5 mm capsule shell thickness, achieving efficient magnetic heating while maintaining mechanical strength (&gt; 2 N), sufficient for withstanding GI transit.The optimized capsule formulation exhibited no cytotoxicity <i>in vitro</i> and remained intact throughout sequential incubation in simulated gastric, intestinal, and colonic fluids. No drug leakage or significant metal leaching (≤ 0.6%) was obtained. The capsule was successfully visualized in a porcine abdominal model using a handheld ultrasound device commonly used at the bedside in the clinic. AMF exposure triggered complete drug release within 33 seconds <i>in vitro</i>. <i>In vivo</i> studies in mice further demonstrated capsule localization via ultrasound, and AMF-triggered capsule melting in the colon via endoscopy. In conclusion, this magnetothermal capsule platform integrates non-invasive imaging and externally triggered drug release to enable localized GI drug delivery, representing a promising strategy for precision treatment of GI diseases.
DOI: 10.3535/1vx-e2a-7cg
title: Hieracium dollineri subsp. pseudaustriacum Zahn

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/dpe-tyb-p5l
title: Elymus repens (L.) Gould

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnb5ch
title: CCDC 605596: Experimental Crystal Structure Determination

description: Related Article: Shuangquan Zang, Yang Su, You Song, Yizhi Li, Zhaoping Ni, Huizhen Zhu, Qingjin Meng|2006|Cryst.Growth Des.|6|2369|doi:10.1021/cg060343u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnpfnd
title: CCDC 616424: Experimental Crystal Structure Determination

description: Related Article: F.G.Vogt, J.Brum, L.M.Katrincic, A.Flach, J.M.Socha, R.M.Goodman, R.C.Haltiwanger|2006|Cryst.Growth Des.|6|2333|doi:10.1021/cg060324k
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13140/rg.2.2.27691.03369
title: Guidance for the National Development from the Anagarika Dharmapala's Tenfold Programme
DOI: 10.3535/0dl-s6l-y0d
title: Asclepias curassavica L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/9hg-vnc-6tm
title: Acanthostyles buniifolius (Hook. & Arn.) R. M. King & H. Rob.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/pqb-gaj-dtw
title: Agropyron Gaertn.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccnb5dj
title: CCDC 605597: Experimental Crystal Structure Determination

description: Related Article: Shuangquan Zang, Yang Su, You Song, Yizhi Li, Zhaoping Ni, Huizhen Zhu, Qingjin Meng|2006|Cryst.Growth Des.|6|2369|doi:10.1021/cg060343u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccnb5fk
title: CCDC 605598: Experimental Crystal Structure Determination

description: Related Article: Shuangquan Zang, Yang Su, You Song, Yizhi Li, Zhaoping Ni, Huizhen Zhu, Qingjin Meng|2006|Cryst.Growth Des.|6|2369|doi:10.1021/cg060343u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/4hd-cv4-zrx
title: Aegilops biuncialis Vis.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/gph-w19-gh7
title: Valeriana officinalis L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/m3q-70x-ctn
title: Cymbalaria microcalyx subsp. microcalyx (Boiss.) Wettst.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp37rr
title: CCDC 628734: Experimental Crystal Structure Determination

description: Related Article: Swee Kuan Yen, Lip Lin Koh, F.E.Hahn, Han Vinh Huynh, T.S.A.Hor|2006|Organometallics|25|5105|doi:10.1021/om060510n
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp37ss
title: CCDC 628735: Experimental Crystal Structure Determination

description: Related Article: Swee Kuan Yen, Lip Lin Koh, F.E.Hahn, Han Vinh Huynh, T.S.A.Hor|2006|Organometallics|25|5105|doi:10.1021/om060510n
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/nr0-kge-36a
title: Chromolaena perijaensis R. M. King & H. Rob.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/t5z-fsq-he1
title: Dryopteris affinis subsp. borreri (Newman) Fraser-Jenk.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/wca-3t5-2jb
title: Hedysarum minjanense Rech. f.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp37qq
title: CCDC 628733: Experimental Crystal Structure Determination

description: Related Article: Swee Kuan Yen, Lip Lin Koh, F.E.Hahn, Han Vinh Huynh, T.S.A.Hor|2006|Organometallics|25|5105|doi:10.1021/om060510n
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13140/rg.2.2.28005.60645
title: Cosmology. image of the Universe in the Early Modern Times/ illustration set pt 1
DOI: 10.3535/y84-lec-92f
title: Taeniatherum caput-medusae (L.) Nevski

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/z66-r7d-18x
title: Aiouea vexatrix van der Werff

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp37pp
title: CCDC 628732: Experimental Crystal Structure Determination

description: Related Article: Swee Kuan Yen, Lip Lin Koh, F.E.Hahn, Han Vinh Huynh, T.S.A.Hor|2006|Organometallics|25|5105|doi:10.1021/om060510n
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3dfl
title: CCDC 628879: Experimental Crystal Structure Determination

description: Related Article: R.D.Adams, B.Captain, E.Trufan, Lei Zhu|2007|J.Am.Chem.Soc.|129|7545|doi:10.1021/ja070617h
description: Related Article: R.D.Adams, B.Captain, Lei Zhu|2006|J.Am.Chem.Soc.|128|13672|doi:10.1021/ja0657152
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/d46-sh0-hcl
title: Hieracium glaucinum subsp. glaucinum Jord.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/dvq-mj6-89w
title: Senecio carniolicus Willd.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/w5h-g06-qgm
title: Potamogeton natans L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3dgm
title: CCDC 628880: Experimental Crystal Structure Determination

description: Related Article: R.D.Adams, B.Captain, E.Trufan, Lei Zhu|2007|J.Am.Chem.Soc.|129|7545|doi:10.1021/ja070617h
description: Related Article: R.D.Adams, B.Captain, Lei Zhu|2006|J.Am.Chem.Soc.|128|13672|doi:10.1021/ja0657152
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3dhn
title: CCDC 628881: Experimental Crystal Structure Determination

description: Related Article: R.D.Adams, B.Captain, E.Trufan, Lei Zhu|2007|J.Am.Chem.Soc.|129|7545|doi:10.1021/ja070617h
description: Related Article: R.D.Adams, B.Captain, Lei Zhu|2006|J.Am.Chem.Soc.|128|13672|doi:10.1021/ja0657152
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/2cc-xg5-ba4
title: Chorispora tenella (Pall.) DC.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/ffe-059-eq3
title: Bromus hordeaceus L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3djp
title: CCDC 628882: Experimental Crystal Structure Determination

description: Related Article: Francisco Estevan, Pipsa Hirva, Mercedes Sanaú, MaAngeles Úbeda|2018|Organometallics|37|2980|doi:10.1021/acs.organomet.8b00342
description: Related Article: F.A.Cotton, I.O.Koshevoy, P.Lahuerta, C.A.Murillo, M.Sanau, M.A.Ubeda, Qinliang Zhao|2006|J.Am.Chem.Soc.|128|13674|doi:10.1021/ja0656595
description: Related Article: D.Penno, V.Lillo, I.O.Koshevoy, M.Sanau, M.A.Ubeda, P.Lahuerta, E.Fernandez|2008|Chem.-Eur.J.|14|10648|doi:10.1002/chem.200800931
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/0f6-vy8-f7e
title: Thymus illyricus Ronniger

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/lm2-l7f-27t
title: Elymus repens (L.) Gould

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/tv8-g9l-mbh
title: Selaginella amazonica Spring

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3dkq
title: CCDC 628883: Experimental Crystal Structure Determination

description: Related Article: Francisco Estevan, Pipsa Hirva, Mercedes Sanaú, MaAngeles Úbeda|2018|Organometallics|37|2980|doi:10.1021/acs.organomet.8b00342
description: Related Article: F.A.Cotton, I.O.Koshevoy, P.Lahuerta, C.A.Murillo, M.Sanau, M.A.Ubeda, Qinliang Zhao|2006|J.Am.Chem.Soc.|128|13674|doi:10.1021/ja0656595
description: Related Article: D.Penno, V.Lillo, I.O.Koshevoy, M.Sanau, M.A.Ubeda, P.Lahuerta, E.Fernandez|2008|Chem.-Eur.J.|14|10648|doi:10.1002/chem.200800931
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3dlr
title: CCDC 628884: Experimental Crystal Structure Determination

description: Related Article: K.M.Knoblock, C.J.Silvestri, D.M.Collard|2006|J.Am.Chem.Soc.|128|13680|doi:10.1021/ja063312w
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/2x8-f7k-jwy
title: Ceiba rivieri (Decne.) Ulbr.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/t3p-7vg-yp3
title: Elymus hispidus (Opiz) Melderis

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3dms
title: CCDC 628885: Experimental Crystal Structure Determination

description: Related Article: J.M.Murphy, J.D.Lawrence, K.Kawamura, C.Incarvito, J.F.Hartwig|2006|J.Am.Chem.Soc.|128|13684|doi:10.1021/ja064092p
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3g3b
title: CCDC 628931: Experimental Crystal Structure Determination

description: Related Article: H.V.R.Dias, S.Singh, J.A.Flores|2006|Inorg.Chem.|45|8859|doi:10.1021/ic061739y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/00g-hna-ddz
title: Geocaryum cynapioides (Guss.) Engstrand

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/nb5-fsj-r6c
title: Microparacaryum salsum (Boiss.) Hilger & Podlech

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/pvd-le5-anb
title: Plantago lagopus L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3g4c
title: CCDC 628932: Experimental Crystal Structure Determination

description: Related Article: H.V.R.Dias, S.Singh, J.A.Flores|2006|Inorg.Chem.|45|8859|doi:10.1021/ic061739y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3g5d
title: CCDC 628933: Experimental Crystal Structure Determination

description: Related Article: H.V.R.Dias, S.Singh, J.A.Flores|2006|Inorg.Chem.|45|8859|doi:10.1021/ic061739y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/1ev-y32-rqq
title: Valantia hispida L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/d9p-6vv-lrb
title: Majorana hortensis Moench

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/gjk-fr4-hq0
title: Molinia caerulea (L.) Moench

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3g6f
title: CCDC 628934: Experimental Crystal Structure Determination

description: Related Article: H.V.R.Dias, S.Singh, J.A.Flores|2006|Inorg.Chem.|45|8859|doi:10.1021/ic061739y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3g7g
title: CCDC 628935: Experimental Crystal Structure Determination

description: Related Article: D.L.Reger, J.R.Gardinier, J.D.Elgin, M.D.Smith, D.Hautot, G.J.Long, F.Grandjean|2006|Inorg.Chem.|45|8862|doi:10.1021/ic0607437
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/226-lg0-tsk
title: Caamembeca oxyphylla (DC.) J. F. B. Pastore

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/smh-2bt-4mm
title: Ruppia L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3g8h
title: CCDC 628936: Experimental Crystal Structure Determination

description: Related Article: D.L.Reger, J.R.Gardinier, J.D.Elgin, M.D.Smith, D.Hautot, G.J.Long, F.Grandjean|2006|Inorg.Chem.|45|8862|doi:10.1021/ic0607437
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.13140/rg.2.2.25892.07049
title: Simulation code
DOI: 10.3535/0dp-4lz-fjm
title: Koeleria Pers.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/vg9-7ba-80f
title: Schultesia brachyptera Cham.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3g9j
title: CCDC 628937: Experimental Crystal Structure Determination

description: Related Article: D.L.Reger, J.R.Gardinier, J.D.Elgin, M.D.Smith, D.Hautot, G.J.Long, F.Grandjean|2006|Inorg.Chem.|45|8862|doi:10.1021/ic0607437
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccp3gbk
title: CCDC 628938: Experimental Crystal Structure Determination

description: Related Article: Banglin Chen, Yu Yang, F.Zapata, Guodong Qian, Yongshi Luo, Jiahua Zhang, E.B.Lobkovsky|2006|Inorg.Chem.|45|8882|doi:10.1021/ic060568u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/fet-9yg-4mh
title: Ornithogalum L.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/lf7-h4v-jkx
title: Eugenia bimarginata O. Berg

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.3535/n0t-k36-1mv
title: Centranthus calcitrapae (L.) Dufr.

description: Digital Specimen for the physical specimen hosted at Natural History Museum Vienna.
DOI: 10.5517/ccp3gcl
title: CCDC 628939: Experimental Crystal Structure Determination

description: Related Article: Banglin Chen, Yu Yang, F.Zapata, Guodong Qian, Yongshi Luo, Jiahua Zhang, E.B.Lobkovsky|2006|Inorg.Chem.|45|8882|doi:10.1021/ic060568u
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.