cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8058740.v2
title: Adipocyte abundances of CES1, CRYAB, ENO1 and GANAB are modified <i>in-vitro</i> by glucose restriction and are associated with cellular remodelling during weight regain

description: Long-term weight loss maintenance is a problem of overweight and obesity. Changes of gene expression during weight loss (WL) by calorie restriction (CR) are linked to the risk of weight regain (WR). However, detailed information on genes/proteins involved in the mechanism is still lacking. Therefore, we developed an <i>in-vitro</i> model system for glucose restriction (GR) and refeeding (RF) to uncover proteome differences between GR with RF vs normal feeding, of which we explored the relation with WR after WL. Human Simpson-Golabi-Behmel Syndrome cells were subjected to changing levels of glucose to mimic the condition of CR and RF. Proteome profiling was performed by liquid chromatography tandem mass spectrometry. This <i>in-vitro</i> model revealed 44 proteins differentially expressed after GR and RF versus feeding including proteins of the focal adhesions. Four proteins showed a persistent up- or down-regulation: liver carboxylesterase (CES1), mitochondrial superoxide dismutase [Mn] (SOD2), alpha-crystallin B-chain (CRYAB), alpha-enolase (ENO1). <i>In-vivo</i> weight loss-induced RNA expression changes linked CES1, CRYAB and ENO1 to WR. Moreover, of these 44 proteins, CES1 and glucosidase II alpha subunit (GANAB) during follow up correlated with WR. Correlation clustering of <i>in-vivo</i> protein expression data indicated an interaction of these proteins with structural components of the focal adhesions and cytoplasmic filaments in the adipocytes.
DOI: 10.6084/m9.figshare.10734989.v1
title: Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures

description: The incidence of obesity has increased dramatically over the past two decades with a prevalence of approximately 40% of the adult population within the United States. The current study examines the potential for transgenerational adipocyte (fat cell) epigenetic alterations. Adipocytes were isolated from the gonadal fat pad of the great-grand offspring F3 generation 1-year old rats ancestrally exposed to DDT (dichlorodiphenyltrichloroethane), atrazine, or vehicle control in order to obtain adipocytes for DNA methylation analysis. Observations indicate that there were differential DNA methylated regions (DMRs) in the adipocytes with the lean or obese phenotypes compared to control normal (non-obese or lean) populations. The comparison of epigenetic alterations indicated that there were substantial overlaps between the different treatment lineage groups for both the lean and obese phenotypes. Novel correlated genes and gene pathways associated with DNA methylation were identified, and may aid in the discovery of potential therapeutic targets for metabolic diseases such as obesity. Observations indicate that ancestral exposures during critical windows of development can induce the epigenetic transgenerational inheritance of DNA methylation changes in adipocytes that ultimately may contribute to an altered metabolic phenotype.
DOI: 10.6084/m9.figshare.7872584
title: Transcriptome profiling reveals association of peripheral adipose tissue pathology with type-2 diabetes in Asian Indians

description: Type 2 diabetes (T2D) is a complex disease with an elusive link between its molecular aetiology and clinical presentation. Although, the role of visceral adipose tissue in insulin-resistance and T2D is known, limited information is available on the role of peripheral-subcutaneous adipose tissue especially in Asian Indians. In this microarray-based study of diabetic and normal glucose tolerant Asian Indians, we generated the transcriptome of their thigh adipose tissue and analyzed differentially expressed genes (DEGs) using weighted gene co-expression network analysis; further we identified perturbed pathways implicated by these DEGs in relevant co-expression modules. We also attempted to link these pathways with known aspects of T2D pathophysiology in terms of their association with some of their intermediate traits, namely; adipocyte size, HOMA-B, HOMA-R, Hb1Ac, insulin, glucose-level, TNF-α, IL-6, VLDLs, LDLs, HDLs, and NEFAs. It was observed that several modules of co-expressed genes show an association with diabetes and some of its intermediate phenotypic traits mentioned above. Therefore, these findings suggest a role of peripheral subcutaneous adipose tissue in the pathophsiology of T2D in Asian Indians. Additionally, our study indicated that the peripheral subcutaneous adipose tissue in diabetics shows pathologic changes characterized by adipocyte hypertrophy and up-regulation of inflammation-related pathways.
DOI: 10.6084/m9.figshare.10734989
title: Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures

description: The incidence of obesity has increased dramatically over the past two decades with a prevalence of approximately 40% of the adult population within the United States. The current study examines the potential for transgenerational adipocyte (fat cell) epigenetic alterations. Adipocytes were isolated from the gonadal fat pad of the great-grand offspring F3 generation 1-year old rats ancestrally exposed to DDT (dichlorodiphenyltrichloroethane), atrazine, or vehicle control in order to obtain adipocytes for DNA methylation analysis. Observations indicate that there were differential DNA methylated regions (DMRs) in the adipocytes with the lean or obese phenotypes compared to control normal (non-obese or lean) populations. The comparison of epigenetic alterations indicated that there were substantial overlaps between the different treatment lineage groups for both the lean and obese phenotypes. Novel correlated genes and gene pathways associated with DNA methylation were identified, and may aid in the discovery of potential therapeutic targets for metabolic diseases such as obesity. Observations indicate that ancestral exposures during critical windows of development can induce the epigenetic transgenerational inheritance of DNA methylation changes in adipocytes that ultimately may contribute to an altered metabolic phenotype.
DOI: 10.6084/m9.figshare.7872584.v3
title: Transcriptome profiling reveals association of peripheral adipose tissue pathology with type-2 diabetes in Asian Indians

description: Type 2 diabetes (T2D) is a complex disease with an elusive link between its molecular aetiology and clinical presentation. Although, the role of visceral adipose tissue in insulin-resistance and T2D is known, limited information is available on the role of peripheral-subcutaneous adipose tissue especially in Asian Indians. In this microarray-based study of diabetic and normal glucose tolerant Asian Indians, we generated the transcriptome of their thigh adipose tissue and analyzed differentially expressed genes (DEGs) using weighted gene co-expression network analysis; further we identified perturbed pathways implicated by these DEGs in relevant co-expression modules. We also attempted to link these pathways with known aspects of T2D pathophysiology in terms of their association with some of their intermediate traits, namely; adipocyte size, HOMA-B, HOMA-R, Hb1Ac, insulin, glucose-level, TNF-α, IL-6, VLDLs, LDLs, HDLs, and NEFAs. It was observed that several modules of co-expressed genes show an association with diabetes and some of its intermediate phenotypic traits mentioned above. Therefore, these findings suggest a role of peripheral subcutaneous adipose tissue in the pathophsiology of T2D in Asian Indians. Additionally, our study indicated that the peripheral subcutaneous adipose tissue in diabetics shows pathologic changes characterized by adipocyte hypertrophy and up-regulation of inflammation-related pathways.
DOI: 10.6084/m9.figshare.8138147.v2
title: Does butein affect adipogenesis?

description: Butein is a plant flavonoid chalcone, with presumed anti-adipogenic properties. It was reported to impair preadipocyte differentiation, limit adipose tissue (AT) development and enhance white AT browning in rodents. In this study, we investigated the hypothesis that these effects of butein may occur via reduction of ADAMTS5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5) expression. Murine 3T3-L1 or 3T3-F442A preadipocytes were differentiated into mature adipocytes in the presence of butein or vehicle. At regular time intervals RNA was collected for gene expression studies. Male hemizygous mice for Tg(Ucp1-luc2,-tdTomato)1Kajim (ThermoMouse) were exposed to butein or vehicle, after which ATs were analyzed for <i>Adamts5</i> and uncoupling protein-1 (<i>Ucp-1</i>) mRNA level changes. During preadipocyte differentiation, butein (25 – 50 mM) did not affect <i>Adamts5</i> or <i>Ucp-1</i> expression. Oil Red O analysis and monitoring of differentiation markers failed to demonstrate effects of butein on the differentiation extent. Furthermore, butein administration to the ThermoMouse (10 or 20 mg/kg, 4 days) or to the C57BL6/Rj mice (20 mg/kg, 4 weeks) did not enhance <i>Adamts5</i> or <i>Ucp-1</i> expression. Thus, we could not demonstrate marked effects of butein on the preadipocyte differentiation extent or AT development and browning, nor on <i>Adamts5</i> or <i>Ucp-1</i> gene expression during these processes.
DOI: 10.6084/m9.figshare.8138147
title: Does butein affect adipogenesis?

description: Butein is a plant flavonoid chalcone, with presumed anti-adipogenic properties. It was reported to impair preadipocyte differentiation, limit adipose tissue (AT) development and enhance white AT browning in rodents. In this study, we investigated the hypothesis that these effects of butein may occur via reduction of ADAMTS5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5) expression. Murine 3T3-L1 or 3T3-F442A preadipocytes were differentiated into mature adipocytes in the presence of butein or vehicle. At regular time intervals RNA was collected for gene expression studies. Male hemizygous mice for Tg(Ucp1-luc2,-tdTomato)1Kajim (ThermoMouse) were exposed to butein or vehicle, after which ATs were analyzed for <i>Adamts5</i> and uncoupling protein-1 (<i>Ucp-1</i>) mRNA level changes. During preadipocyte differentiation, butein (25 – 50 mM) did not affect <i>Adamts5</i> or <i>Ucp-1</i> expression. Oil Red O analysis and monitoring of differentiation markers failed to demonstrate effects of butein on the differentiation extent. Furthermore, butein administration to the ThermoMouse (10 or 20 mg/kg, 4 days) or to the C57BL6/Rj mice (20 mg/kg, 4 weeks) did not enhance <i>Adamts5</i> or <i>Ucp-1</i> expression. Thus, we could not demonstrate marked effects of butein on the preadipocyte differentiation extent or AT development and browning, nor on <i>Adamts5</i> or <i>Ucp-1</i> gene expression during these processes.
DOI: 10.5519/qd.tbd4lzn0
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (40 records)
DOI: 10.7910/dvn/89y8yc/yhgfgs
title: SYPE 2014 V4.5.tab
DOI: 10.7910/dvn/89y8yc/gvbj6e
title: SYPE 2009 V2.tab
DOI: 10.5281/zenodo.7765551
title: Association of PD-L1 immunoexpression with the clinicopathological characteristics and its prognostic significance in OPMD and OSCC

description: Master chart for Oral Potentially Premalignant cases and Oral Squamous Cell carcinoma cases.
DOI: 10.5281/zenodo.7765550
title: Association of PD-L1 immunoexpression with the clinicopathological characteristics and its prognostic significance in OPMD and OSCC

description: Master chart for Oral Potentially Premalignant cases and Oral Squamous Cell carcinoma cases.
DOI: 10.5519/qd.2he2815y
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (28780 records)
DOI: 10.21227/c3bb-6y08
title: Affect recognition in muscular response signals

description: 10 soccer supporters gathered to watch a live broadcasted Premier League
match between Liverpool and Manchester United (4 - 0) on 19th of March 2022, all
equipped with wrist-worn accelerometers. All participants were aware of the purpose of this experiment and consented to participate
by attendance at the event, and by wearing the accelerometer. No personally sensitive
information was collected, all data is fully anonymised following the GDPR guidelines
and all procedures were in accordance with the recommendations of the data protection
agent at the Oslo Metropolitan University.
DOI: 10.11588/data/hj6svm/gkhegm
title: readme.txt

description: :unav
DOI: 10.11588/data/hj6svm/8cq2xg
title: run_input_tprfiles_main.zip

description: :unav
DOI: 10.5519/qd.kucsofe8
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (10631 records)
DOI: 10.11588/data/hj6svm/7kwwkg
title: run_input_tprfiles_KIMMDY.zip

description: :unav
DOI: 10.11588/data/hj6svm/hy0e5n
title: data_PYD_crosslinks.csv

description: :unav
DOI: 10.11588/data/hj6svm/6ch8t3
title: runs_overwiev.csv

description: :unav
DOI: 10.11588/data/hj6svm/qnwzkl
title: data_HLKNL_crosslinks.csv

description: :unav
DOI: 10.11588/data/hj6svm/0hplfq
title: data_HLKNL_crosslinks_force_corrected_SI.csv

description: :unav
DOI: 10.11588/data/hj6svm/lkhgzf
title: data_PYD_protonated_crosslinks.csv

description: :unav
DOI: 10.11588/data/hj6svm/bin6jh
title: Values_control_sample1_nobackground_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/6qyilq
title: Values_stressed500ug_sample3_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/3sbczo
title: original_stressed_RTT.jpg

description: :unav
DOI: 10.11588/data/hj6svm/3vpskt
title: Values_control_sample3_nobackground_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/9bvlhy
title: original_20230119.jpg

description: :unav
DOI: 10.11588/data/hj6svm/3dimph
title: Values_stressed500ug_sample1_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/axgyaw
title: sequence_coverage.tab

description: :unav
DOI: 10.11588/data/hj6svm/gfwwqr
title: bands_relative_ratios.tab

description: :unav
DOI: 10.11588/data/hj6svm/lcgbf3
title: Values_control_sample4_nobackground_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/9c8cpy
title: original_control_RTT.jpg

description: :unav
DOI: 10.11588/data/hj6svm/9o3g2g
title: Values_control_sample2_nobackground_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/jwm706
title: band_intensity_ratios.tab

description: :unav
DOI: 10.11588/data/hj6svm/7b7pho
title: IMG_20230119_bw_inverted_nobackground_rotated.jpg

description: :unav
DOI: 10.11588/data/hj6svm/szcu1j
title: Values_stressed500ug_sample2_inverted.tab

description: :unav
DOI: 10.11588/data/hj6svm/h46nqd
title: Values_stressed500ug_sample4_inverted.tab

description: :unav
DOI: 10.6084/m9.figshare.22332587
title: Mid-Ordovician stratigraphy and volcanism in the Hølonda area, Scandinavian Caledonides: complex tectonomagmatic development following arc–continent collision near the Laurentian margin of Iapetus

description: Table S1. Whole-rock geochemical data (Excel table), including isotopes.
DOI: 10.6084/m9.figshare.22332587.v1
title: Mid-Ordovician stratigraphy and volcanism in the Hølonda area, Scandinavian Caledonides: complex tectonomagmatic development following arc–continent collision near the Laurentian margin of Iapetus

description: Table S1. Whole-rock geochemical data (Excel table), including isotopes.
DOI: 10.6084/m9.figshare.22332590.v1
title: Mid-Ordovician stratigraphy and volcanism in the Hølonda area, Scandinavian Caledonides: complex tectonomagmatic development following arc–continent collision near the Laurentian margin of Iapetus

description: Table S5. U–Pb TIMS data Nonsåsen volcanic unit (Excel table).
DOI: 10.6084/m9.figshare.22332590
title: Mid-Ordovician stratigraphy and volcanism in the Hølonda area, Scandinavian Caledonides: complex tectonomagmatic development following arc–continent collision near the Laurentian margin of Iapetus

description: Table S5. U–Pb TIMS data Nonsåsen volcanic unit (Excel table).
DOI: 10.6084/m9.figshare.22332599
title: Mid-Ordovician stratigraphy and volcanism in the Hølonda area, Scandinavian Caledonides: complex tectonomagmatic development following arc–continent collision near the Laurentian margin of Iapetus

description: Table S6. LA–ICP–MS detrital zircon data (Excel table).
DOI: 10.6084/m9.figshare.22332599.v1
title: Mid-Ordovician stratigraphy and volcanism in the Hølonda area, Scandinavian Caledonides: complex tectonomagmatic development following arc–continent collision near the Laurentian margin of Iapetus

description: Table S6. LA–ICP–MS detrital zircon data (Excel table).
DOI: 10.5281/zenodo.7767453
title: calameuta_filiformis_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.5281/zenodo.7767452
title: calameuta_filiformis_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.5517/ccdc.csd.cc27zxgm
title: CCDC 2085291: Experimental Crystal Structure Determination

description: Related Article: Marta Castineira Reis|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dcmp3
title: CCDC 2215715: Experimental Crystal Structure Determination

description: Related Article: Yingyu Li|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dcmr5
title: CCDC 2215717: Experimental Crystal Structure Determination

description: Related Article: Yingyu Li|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dcmw9
title: CCDC 2215721: Experimental Crystal Structure Determination

description: Related Article: Yingyu Li|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.7767476
title: calameuta_filum_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.5281/zenodo.7767475
title: calameuta_filum_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.6084/m9.figshare.22332619
title: Self-learning techniques of medical student

description: This data provides information about general information, self-learning techniques and relevant characteristic of the participants.
DOI: 10.6084/m9.figshare.22332619.v1
title: Self-learning techniques of medical student

description: This data provides information about general information, self-learning techniques and relevant characteristic of the participants.
DOI: 10.17632/ffcyy3b34h.1
title: SupplementaryFigures for Trans-generation epigenetic effects driven by maternal phenotypes in dairy cattle. A co-methylation network approach

description: Supplementary figures and list of genes for the paper Trans-generation epigenetic effects driven by maternal phenotypes in dairy cattle. A co-methylation network approach
DOI: 10.17632/k7675c7tx9.1
title: CCSP: Mastering Cloud Security

description: CCSP, or Certified Cloud Security Professional, is a certification program that focuses on the knowledge and skills required to design, manage, and secure cloud environments. The <a href="https://www.igmguru.com/course/ccsp-isc2-certification-training/">CCSP Training</a>  certification is designed for IT professionals who are responsible for ensuring the security of cloud-based applications, services, and data.

Mastering cloud security is an essential requirement in today's technology-driven world. As more and more organizations move their data and applications to the cloud, the need for skilled professionals who can secure these environments has increased exponentially. The CCSP certification provides a comprehensive understanding of cloud security, including architecture, design, operations, and compliance.

To achieve CCSP certification, candidates must have a minimum of five years of IT experience, with three years of experience in information security and one year in cloud computing. The CCSP exam covers six domains: Cloud Concepts, Architecture and Design, Cloud Data Security, Cloud Platform and Infrastructure Security, Cloud Application Security, and Legal, Risk, and Compliance.

By earning the CCSP certification, IT professionals demonstrate their expertise in securing cloud-based applications, services, and data. It not only enhances their skills and knowledge but also increases their employability and earning potential. CCSP certified professionals can work as cloud security architects, engineers, consultants, analysts, and managers in a variety of industries.
DOI: 10.17632/k7675c7tx9.2
title: CCSP: Mastering Cloud Security

description: CCSP, or Certified Cloud Security Professional, is a certification program that focuses on the knowledge and skills required to design, manage, and secure cloud environments. The CCSP Training  certification is designed for IT professionals who are responsible for ensuring the security of cloud-based applications, services, and data.

Mastering cloud security is an essential requirement in today's technology-driven world. As more and more organizations move their data and applications to the cloud, the need for skilled professionals who can secure these environments has increased exponentially. The CCSP certification provides a comprehensive understanding of cloud security, including architecture, design, operations, and compliance.

To achieve CCSP certification, candidates must have a minimum of five years of IT experience, with three years of experience in information security and one year in cloud computing. The CCSP exam covers six domains: Cloud Concepts, Architecture and Design, Cloud Data Security, Cloud Platform and Infrastructure Security, Cloud Application Security, and Legal, Risk, and Compliance.

By earning the CCSP certification, IT professionals demonstrate their expertise in securing cloud-based applications, services, and data. It not only enhances their skills and knowledge but also increases their employability and earning potential. CCSP certified professionals can work as cloud security architects, engineers, consultants, analysts, and managers in a variety of industries.
DOI: 10.17632/htg5skmj55.1
title: Analysis of a biopolymer implementation in the automotive instrument panel

description: This work will analyze the Polypropylene´s behavior in the vehicle dashboard, this is an original material used by Ford Motor Company, and will be compared against the behavior of poly-lactic acid (PLA) which this study shows provides a better response to the knees impact against the dashboard, in addition to being a biopolymer the ecological impact is less than the synthetic polymers.
DOI: 10.17632/6tmhczfv82.1
title: Dataset for: Does capital structure affect profitability? Evidence from Ghanaian listed firms