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DOI: 10.6084/m9.figshare.21340478
title: Additional file 8 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents

description: Additional file 8: Table S7. Genomic and proteomic information of 20 MAGs recovered in this study.
DOI: 10.6084/m9.figshare.21340481.v1
title: Additional file 9 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents

description: Additional file 9: Table S8. Genomic and proteomic data of the predominant Nautiliaceae and Thiomicrorhabdus MAGs used for metabolic modules reconstruction.
DOI: 10.6084/m9.figshare.19767745
title: Additional file 3 of Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array

description: Additional file 3. Enrichment statistics for the TF motifs enriched at female-biased CpGs.
DOI: 10.6084/m9.figshare.21340511.v1
title: Additional file 4 of Functional differentiation determines the molecular basis of the symbiotic lifestyle of Ca. Nanohaloarchaeota

description: Additional file 4. All commands, scripts, and R codes are included.
DOI: 10.6084/m9.figshare.21340511
title: Additional file 4 of Functional differentiation determines the molecular basis of the symbiotic lifestyle of Ca. Nanohaloarchaeota

description: Additional file 4. All commands, scripts, and R codes are included.
DOI: 10.6084/m9.figshare.15049094
title: Incomplete thermal ablation-induced up-regulation of transcription factor nuclear receptor subfamily 2, group F, member 6 (NR2F6) contributes to the rapid progression of residual liver tumor in hepatoblastoma

description: Hepatoblastoma is a kind of extreme malignancy frequently diagnosed in children. Although surgical resection is considered as the first-line treatment for hepatoblastoma, a relatively large population of patients have lost the preferred opportunity for surgery. Administration of locoregional ablation enables local tumor control but with the deficiency of insufficient ablation, residual tumor, and rapid progression. In this study, we integrated 219 hepatoblastoma and 121 non-cancer liver tissues to evaluate the expression of NR2F6, from which a higher NR2F6 level was found in hepatoblastoma compared with non-cancer livers with a standard mean difference (SMD) of 1.04 (95% CI: 0.79, 1.29). The overexpression of NR2F6 also appeared to be an efficient indicator in distinguishing hepatoblastoma tissues from non-cancer liver tissues from the indication of a summarized AUC of 0.90, with a pooled sensitivity of 0.76 and a pooled specificity of 0.89. Interestingly, nude mouse xenografts provided direct evidence that overexpressed NR2F6 was also detected in residual tumor compared to untreated hepatoblastoma. Chromatin immunoprecipitation-binding data in HepG2 cells and transcriptome analysis of HepG2 xenografts were combined to identify target genes regulated by NR2F6. We finally selected 150 novel target genes of NR2F6 in residual tumor of incomplete ablation, and these genes appeared to be associated with the biological regulation of lipid metabolism-related pathway. Accordingly, targeting NR2F6 holds a therapeutic promise in treating residual recurrent hepatoblastoma after incomplete ablation.
DOI: 10.6084/m9.figshare.15049094.v1
title: Incomplete thermal ablation-induced up-regulation of transcription factor nuclear receptor subfamily 2, group F, member 6 (NR2F6) contributes to the rapid progression of residual liver tumor in hepatoblastoma

description: Hepatoblastoma is a kind of extreme malignancy frequently diagnosed in children. Although surgical resection is considered as the first-line treatment for hepatoblastoma, a relatively large population of patients have lost the preferred opportunity for surgery. Administration of locoregional ablation enables local tumor control but with the deficiency of insufficient ablation, residual tumor, and rapid progression. In this study, we integrated 219 hepatoblastoma and 121 non-cancer liver tissues to evaluate the expression of NR2F6, from which a higher NR2F6 level was found in hepatoblastoma compared with non-cancer livers with a standard mean difference (SMD) of 1.04 (95% CI: 0.79, 1.29). The overexpression of NR2F6 also appeared to be an efficient indicator in distinguishing hepatoblastoma tissues from non-cancer liver tissues from the indication of a summarized AUC of 0.90, with a pooled sensitivity of 0.76 and a pooled specificity of 0.89. Interestingly, nude mouse xenografts provided direct evidence that overexpressed NR2F6 was also detected in residual tumor compared to untreated hepatoblastoma. Chromatin immunoprecipitation-binding data in HepG2 cells and transcriptome analysis of HepG2 xenografts were combined to identify target genes regulated by NR2F6. We finally selected 150 novel target genes of NR2F6 in residual tumor of incomplete ablation, and these genes appeared to be associated with the biological regulation of lipid metabolism-related pathway. Accordingly, targeting NR2F6 holds a therapeutic promise in treating residual recurrent hepatoblastoma after incomplete ablation.
DOI: 10.6084/m9.figshare.19767748.v1
title: Additional file 4 of Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array

description: Additional file 4. Enrichment statistics for the TF motifs enriched at male-biased CpGs.
DOI: 10.6084/m9.figshare.19767751
title: Additional file 5 of Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array

description: Additional file 5. Genes annotated to saDMPs via Hi-C analysis.
DOI: 10.6084/m9.figshare.9809642
title: MOESM2 of Estrogen receptors promote NSCLC progression by modulating the membrane receptor signaling network: a systems biology perspective

description: Additional file 2. Complete results of the GO and KEGG enrichment analysis.
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n.1
title: 5-methylbenzene-1,3-diol;hydrate
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2, and canonical SMILES descriptor[cheminf_000007]: Cc1cc(O)cc(c1)O.O, and by the IUPAC name[cheminf_000107]: 5-methylbenzene-1,3-diol;hydrate.
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-36497

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000596 | distortionless enhancement with polarization transfer (DEPT)
 
 CHMO:0000599 | correlation spectroscopy (COSY)
 
 CHMO:0000604 | heteronuclear single quantum coherence (HSQC)
 
 CHMO:0000601 | heteronuclear multiple bond coherence (HMBC)
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, DMSO-d6 [2.50 ppm], ppm) δ = 9.02 (s, 2H), 6.02–6.00 (m, 3H), 2.10 (s, 3H). Missing signal: (2H) from the monohydrate
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000599
title: correlation spectroscopy (COSY) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for correlation spectroscopy (COSY)
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000604
title: heteronuclear single quantum coherence (HSQC) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for heteronuclear single quantum coherence (HSQC)
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000596
title: distortionless enhancement with polarization transfer (DEPT) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for distortionless enhancement with polarization transfer (DEPT)
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, DMSO-d6 [39.5 ppm], ppm) δ = 158.3 (2C), 139.2 (Cq), 107.1 (2C, CH), 99.8 (CH), 21.3 (CH3).
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000601
title: heteronuclear multiple bond coherence (HMBC) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for heteronuclear multiple bond coherence (HMBC)
DOI: 10.14272/nbkpnamthbimla-uhfffaoysa-n/chmo0000596.1
title: distortionless enhancement with polarization transfer (DEPT) (5-methylbenzene-1,3-diol;hydrate)
title: InChI=1S/C7H8O2.H2O/c1-5-2-6(8)4-7(9)3-5;/h2-4,8-9H,1H3;1H2

description: dataset for distortionless enhancement with polarization transfer (DEPT)