cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19746487
title: Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway

description: Globally, age-related macular degeneration (AMD) is a common irreversible ophthalmopathy. Oxidative stress of retinal pigment epithelial cells is involved in AMD occurrence and development. Klotho is an anti-aging protein with antioxidant properties. We investigated the protective properties of Klotho on hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced injury of retinal pigment epithelial cells (ARPE-19 cells) and its associated pathomechanisms. We found that Klotho pretreatment for 24 h could up-regulate Bcl-2 levels, decrease the cleaved-caspase-3 and Bax levels, inhibit H<sub>2</sub>O<sub>2</sub>-induced ARPE-19 cell apoptosis, and promote cell proliferation. Klotho pretreatment inhibited the H<sub>2</sub>O<sub>2</sub>-mediated elevations of reactive oxygen species (ROS) in ARPE-19 cells. It enhanced antioxidant activities of the cells and restored the glutathione peroxidase (GPX), superoxide dismutase (SOD2), catalase (CAT), as well as malondialdehyde (MDA) levels to close to the normal level. N-acetylcysteine (NAC), a reactive oxygen scavenger, could reverse the harmful effects of H<sub>2</sub>O<sub>2</sub> on proliferation, apoptosis, and oxidative stress of ARPE-19 cells. Further, Klotho pretreatment enhanced Akt phosphorylation and expression as well as nuclear translocation of Nrf2 in H<sub>2</sub>O<sub>2</sub>-treated ARPE-19 cells. This indicates that Klotho protects cells from oxidative stress by activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)-nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) signaling pathway. Klotho is, therefore, a potential preventive or treatment option for AMD.
DOI: 10.6084/m9.figshare.11358128
title: MOESM5 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 5: Table S2. Differentially Methylated 2â€‰kb regions.
DOI: 10.6084/m9.figshare.11358146
title: MOESM9 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 9: Table S5. Primers utilized in this study.
DOI: 10.6084/m9.figshare.11358146.v1
title: MOESM9 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 9: Table S5. Primers utilized in this study.
DOI: 10.6084/m9.figshare.11358128.v1
title: MOESM5 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 5: Table S2. Differentially Methylated 2â€‰kb regions.
DOI: 10.6084/m9.figshare.13979395.v1
title: Additional file 1 of Quantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants

description: Additional file 1: Figure S1. Quality control for the mass spectrometry identification process. The peptide length distribution (A) and the mass error distribution (B) are shown.
DOI: 10.6084/m9.figshare.11358134
title: MOESM7 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 7: Table S3. Methylation levels of imprinted DMRs in individuals with maternal NLRP5 variants.
DOI: 10.6084/m9.figshare.11358110.v1
title: MOESM3 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 3: Table S1. Statistical analysis.
DOI: 10.6084/m9.figshare.6115211
title: Carbon dioxide emissions from cascade hydropower reservoirs along the Wujiang River, China

description: Currently, CO<sub>2</sub> emissions from cascade hydropower reservoirs are not well understood. In this study, we investigated the seasonal carbon dioxide partial pressure (<i>p</i>CO<sub>2</sub>) and related environmental factors in 4 cascading reservoirs (Hong Jia Du, Dong Feng, Suo Feng Ying, and Wu Jiang Du) of Wujiang River, southwest China. The results showed that <i>p</i>CO<sub>2</sub> in the surface water of these reservoirs had obvious spatiotemporal changes and generally decreased from the riverine zone to the lacustrine zone in each reservoir. In summer, <i>p</i>CO<sub>2</sub> was highest downstream of the dam because of stratification and deep water discharge for hydropower generation, whereas <i>p</i>CO<sub>2</sub> was much lower in the surface water of the lacustrine zone because of carbon removal by photosynthesis. When water temperature was low, however, <i>p</i>CO<sub>2</sub> was higher in the surface water of the lacustrine zone because of respiration and organic decomposition. Among these reservoirs, only Suo Feng Ying had CO<sub>2</sub> emissions higher than the average value of natural lakes. In addition, CO<sub>2</sub> emission flux showed an exponentially negative relationship with hydraulic retention time of reservoirs, based on this work and other reports of reservoirs in the Yangtze River basin.
DOI: 10.6084/m9.figshare.6115211.v1
title: Carbon dioxide emissions from cascade hydropower reservoirs along the Wujiang River, China

description: Currently, CO<sub>2</sub> emissions from cascade hydropower reservoirs are not well understood. In this study, we investigated the seasonal carbon dioxide partial pressure (<i>p</i>CO<sub>2</sub>) and related environmental factors in 4 cascading reservoirs (Hong Jia Du, Dong Feng, Suo Feng Ying, and Wu Jiang Du) of Wujiang River, southwest China. The results showed that <i>p</i>CO<sub>2</sub> in the surface water of these reservoirs had obvious spatiotemporal changes and generally decreased from the riverine zone to the lacustrine zone in each reservoir. In summer, <i>p</i>CO<sub>2</sub> was highest downstream of the dam because of stratification and deep water discharge for hydropower generation, whereas <i>p</i>CO<sub>2</sub> was much lower in the surface water of the lacustrine zone because of carbon removal by photosynthesis. When water temperature was low, however, <i>p</i>CO<sub>2</sub> was higher in the surface water of the lacustrine zone because of respiration and organic decomposition. Among these reservoirs, only Suo Feng Ying had CO<sub>2</sub> emissions higher than the average value of natural lakes. In addition, CO<sub>2</sub> emission flux showed an exponentially negative relationship with hydraulic retention time of reservoirs, based on this work and other reports of reservoirs in the Yangtze River basin.
DOI: 10.6084/m9.figshare.13979395
title: Additional file 1 of Quantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants

description: Additional file 1: Figure S1. Quality control for the mass spectrometry identification process. The peptide length distribution (A) and the mass error distribution (B) are shown.
DOI: 10.6084/m9.figshare.16601049
title: Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis

description: Hepatocellular carcinoma (HCC) is a primary liver cancer with high morbidity and mortality. An increasing number of abnormal gene expressions were identified to be associated with the progression of HCC. Previous studies showed that the hsa-miR-30 c-5p (miR-30 c), one of the miR-30 family members, might play a role in suppressing tumor progression in a variety of tumors. The present study aims to examine miR-30 c effects in the development of HCC. The role of miR-30 c in HCC was comprehensively investigated by using bioinformatics and experiments <i>in vitro</i>. The multiple databases were combined to predict and screen the target genes and upstream lncRNAs of miR-30 c, and then constructed a competitive endogenous RNA (ceRNA) regulatory network with miR-30 c as the central miRNA. The miR-30 c-related ceRNA regulatory network was also initially validated <i>in vitro</i>. The results showed that miR-30 c over-expression could inhibit proliferation, migration, invasion, induce apoptosis, and increase G0/G1 phase ratio of HCC cells. Three miR-30 c upstream lncRNAs and 12 miR-30 c target genes were expressed in HCC cells with increased expression and poor prognosis, and a miR-30 C-related ceRNA regulatory network was constructed. This study verified miR-30 c as an inhibitory factor in the progression of HCC and performed analyses on the miR-30 c regulatory network, which might provide potential target information for HCC prognoses and therapies. However, further experiments <i>in vivo</i> and studies including clinical trials will be conducted to validate our results.
DOI: 10.6084/m9.figshare.11358143
title: MOESM8 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 8: Table S4. Sex and age information of controls.
DOI: 10.6084/m9.figshare.11358143.v1
title: MOESM8 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 8: Table S4. Sex and age information of controls.
DOI: 10.6084/m9.figshare.11358290
title: MOESM3 of Morphology is not a reliable taxonomic tool for the genus Lernaea: molecular data and experimental infection reveal that L. cyprinacea and L. cruciata are conspecific

description: Additional file 3: Table S3. Sequences used for the phylogenetic analyses in this study.
DOI: 10.48328/tudatalib-1349
title: Editierbares Parameterverzeichnis

description: Diese zusätzlichen Informationen dokumentieren den Umsetzungsprozess der erweiterten Ökobilanzierung. Im ersten Teil erfolgt die Generierung von Parametern für den frühen Technologieentwicklungprozess einer neuartigen Technologie in der ex-ante Sachbilanz. Im zweiten Teil folgt die zukunftsgerichtete Modifizierung von Parametern für den Szenarioentwicklungsprozess sowie Datentechniken und Visualisierung für die Annahmen des Zukunftsszenarios in der prospektiven Sachbilanz.
DOI: 10.6084/m9.figshare.16601049.v2
title: Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis

description: Hepatocellular carcinoma (HCC) is a primary liver cancer with high morbidity and mortality. An increasing number of abnormal gene expressions were identified to be associated with the progression of HCC. Previous studies showed that the hsa-miR-30 c-5p (miR-30 c), one of the miR-30 family members, might play a role in suppressing tumor progression in a variety of tumors. The present study aims to examine miR-30 c effects in the development of HCC. The role of miR-30 c in HCC was comprehensively investigated by using bioinformatics and experiments <i>in vitro</i>. The multiple databases were combined to predict and screen the target genes and upstream lncRNAs of miR-30 c, and then constructed a competitive endogenous RNA (ceRNA) regulatory network with miR-30 c as the central miRNA. The miR-30 c-related ceRNA regulatory network was also initially validated <i>in vitro</i>. The results showed that miR-30 c over-expression could inhibit proliferation, migration, invasion, induce apoptosis, and increase G0/G1 phase ratio of HCC cells. Three miR-30 c upstream lncRNAs and 12 miR-30 c target genes were expressed in HCC cells with increased expression and poor prognosis, and a miR-30 C-related ceRNA regulatory network was constructed. This study verified miR-30 c as an inhibitory factor in the progression of HCC and performed analyses on the miR-30 c regulatory network, which might provide potential target information for HCC prognoses and therapies. However, further experiments <i>in vivo</i> and studies including clinical trials will be conducted to validate our results.
DOI: 10.6084/m9.figshare.11358278.v1
title: MOESM2 of Morphology is not a reliable taxonomic tool for the genus Lernaea: molecular data and experimental infection reveal that L. cyprinacea and L. cruciata are conspecific

description: Additional file 2: Table S2. Sequences used for the comparative analyses in this study.
DOI: 10.5281/zenodo.8345058
title: From MS/MS Library Implementation to Molecular Networks: Exploring Oxylipin Diversity with NEO-MSMS library

description: Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids (PUFAs), serve as biomarkers for diseases and play crucial roles in human physiology and inflammation. Despite their significance, many non-enzymatic oxygenated metabolites of PUFAs (NEO-PUFAs) remain poorly reported, resulting in a lack of public datasets of experimental data and limiting their dereplication in further studies. To overcome this limitation, we constructed a high-resolution tandem mass spectrometry (MS/MS) database comprising pure NEO-PUFA (both commercial and synthesized) and in vitro free radical-induced oxidations of diverse PUFAs and oxylipins. Furthermore, we conducted various molecular networking analyses on these standards, as well as on in vitro free radical-induced oxidations, serum samples, and algae samples. This was done to demonstrate their potential in derreplication and to provide additional putative oxylipins This dataset contains all the data used in this study including the raw data and the MzMine 3 procesed data used to built the molecular networks (i.e. feature tables and MSMS spectra).


The folder ‘libraries’ contained the NEO-MSMS library divided into three .mgf files, i.e., the standards obtained with Q-Exactive Focus (i.e. NEOMSMS_QFocus_lib.mgf), Orbitrap ID-X Tribrid (i.e. NEOMSMS_idX_lib.mgf), and from the Watrous et al. study (Cell Chem Biol., 2019; 26(3):433-442) (NEOMSMS_Watrous_lib.mgf). Moreover, the individual .mgf files from each compound was included in three subfolders following the same syntax. The folder ‘oxPUFAs’ contains the raw .mzML files of the LC-MSMS analysis and the mzMine alignment results (i.e., the feature tables and the extracted .mgf files) of the in vitro oxidized PUFAs. The folder ‘algae_serum’ contains the same type of data from the algae and serum samples. The folder ‘oxOxylipins’ contains the raw .mzML files of the LC-MSMS analysis of the miniaturized oxidation of HETE, rearrangement of PGH1 and PGH2. Finally, the ‘putative_lib´ folder contains the putatively annotated oxylipins in the same structure as ‘libraries’ folder.
description: We would like to express our gratitude to the support of the Région Occitanie through the prematuration project MNE-AGPI-03. Á.S.I. acknowledges the support of Margarita Salas grant [UP2021-044-MS21-084] from the Ministry of Universities of the Government of Spain, financed by the European Union, NextGeneration EU and CIGE/2022/107 research project from Generalitat Valenciana, Conselleria d'Educació, Universitats i Ocupació. All authors also acknowledge the equipment employed to Laboratoire de Mesures Physiques platform at Institut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, Université de Montpellier, Montpellier, France.
DOI: 10.5281/zenodo.8345059
title: From MS/MS Library Implementation to Molecular Networks: Exploring Oxylipin Diversity with NEO-MSMS library

description: Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids (PUFAs), serve as biomarkers for diseases and play crucial roles in human physiology and inflammation. Despite their significance, many non-enzymatic oxygenated metabolites of PUFAs (NEO-PUFAs) remain poorly reported, resulting in a lack of public datasets of experimental data and limiting their dereplication in further studies. To overcome this limitation, we constructed a high-resolution tandem mass spectrometry (MS/MS) database comprising pure NEO-PUFA (both commercial and synthesized) and in vitro free radical-induced oxidations of diverse PUFAs and oxylipins. Furthermore, we conducted various molecular networking analyses on these standards, as well as on in vitro free radical-induced oxidations, serum samples, and algae samples. This was done to demonstrate their potential in derreplication and to provide additional putative oxylipins This dataset contains all the data used in this study including the raw data and the MzMine 3 procesed data used to built the molecular networks (i.e. feature tables and MSMS spectra).


The folder ‘libraries’ contained the NEO-MSMS library divided into three .mgf files, i.e., the standards obtained with Q-Exactive Focus (i.e. NEOMSMS_QFocus_lib.mgf), Orbitrap ID-X Tribrid (i.e. NEOMSMS_idX_lib.mgf), and from the Watrous et al. study (Cell Chem Biol., 2019; 26(3):433-442) (NEOMSMS_Watrous_lib.mgf). Moreover, the individual .mgf files from each compound was included in three subfolders following the same syntax. The folder ‘oxPUFAs’ contains the raw .mzML files of the LC-MSMS analysis and the mzMine alignment results (i.e., the feature tables and the extracted .mgf files) of the in vitro oxidized PUFAs. The folder ‘algae_serum’ contains the same type of data from the algae and serum samples. The folder ‘oxOxylipins’ contains the raw .mzML files of the LC-MSMS analysis of the miniaturized oxidation of HETE, rearrangement of PGH1 and PGH2. Finally, the ‘putative_lib´ folder contains the putatively annotated oxylipins in the same structure as ‘libraries’ folder.
description: We would like to express our gratitude to the support of the Région Occitanie through the prematuration project MNE-AGPI-03. Á.S.I. acknowledges the support of Margarita Salas grant [UP2021-044-MS21-084] from the Ministry of Universities of the Government of Spain, financed by the European Union, NextGeneration EU and CIGE/2022/107 research project from Generalitat Valenciana, Conselleria d'Educació, Universitats i Ocupació. All authors also acknowledge the equipment employed to Laboratoire de Mesures Physiques platform at Institut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, Université de Montpellier, Montpellier, France.
DOI: 10.6084/m9.figshare.11358110
title: MOESM3 of The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype

description: Additional file 3: Table S1. Statistical analysis.
DOI: 10.6084/m9.figshare.21316278.v1
title: Additional file 4 of Novel six-gene prognostic signature based on colon adenocarcinoma immune-related genes

description: Additional file4. TCGA data.
DOI: 10.6084/m9.figshare.23354105
title: An Empirical Model of Factors Affecting Customer Satisfaction with Mobile Takeaway Apps: Meituan App as a case studym

description: Mobile Apps accompanied by the rapid development of mobile Internet technology and the rapid changing of people's living style; Mobile Apps have been utilizing very frequently in almost every aspect in China. This study aims to identify factors affecting the customers’ satisfaction with Mobile takeaway Apps and focus on Meituan App (Takeaway function). By introducing eight variables, the present study provided a research model via the mediator of Herd Behavior (HB). The data was analyzed using SPSS to conduct descriptive statistics and Warp-PLS 7.0 was used to verify the model and its hypothesis. The mediated effects of intermediary variables were investigated using the Mplus 8.3 tool. The results demonstrated that the mediator of Herd Behavior together with other two important factors including expectation confirmation and perceived value played essential roles on customers’ satisfaction. Therefore, it was suggested that some marketing strategies and tactics associated with the Mobile App on takeaway function should be developed.
DOI: 10.6084/m9.figshare.23354105.v1
title: An Empirical Model of Factors Affecting Customer Satisfaction with Mobile Takeaway Apps: Meituan App as a case studym

description: Mobile Apps accompanied by the rapid development of mobile Internet technology and the rapid changing of people's living style; Mobile Apps have been utilizing very frequently in almost every aspect in China. This study aims to identify factors affecting the customers’ satisfaction with Mobile takeaway Apps and focus on Meituan App (Takeaway function). By introducing eight variables, the present study provided a research model via the mediator of Herd Behavior (HB). The data was analyzed using SPSS to conduct descriptive statistics and Warp-PLS 7.0 was used to verify the model and its hypothesis. The mediated effects of intermediary variables were investigated using the Mplus 8.3 tool. The results demonstrated that the mediator of Herd Behavior together with other two important factors including expectation confirmation and perceived value played essential roles on customers’ satisfaction. Therefore, it was suggested that some marketing strategies and tactics associated with the Mobile App on takeaway function should be developed.
DOI: 10.5281/zenodo.8015758
title: C-axis data from 3 depths at EGRIP

description: C-axis data as azimuth and latitude in degrees, from 3 depths at EGRIP: 145.93m, 1048.3m, 1449.07m
DOI: 10.4227/05/5088f8b5f1921
title: Goorooyarroo Nature Reserve Site 2, ACT. Ver. 1. VAST-2: Tracking the Transformation of Australia's Vegetated Landscapes. Australian Centre for Ecological Analysis and Synthesis, University of Queensland, Brisbane
DOI: 10.6084/m9.figshare.23354093
title: Chlorophyll-a and suspended sediment inversion

description: index.xlsx: The file provides the spectral and spectral index values of the P4M, X20, Sentinel-2, Landsat8, and Landsat9 sensors used to acquire images at the sampling points. Predict_SS.zip:This file provides the predicted values of suspended sediment for each sensor based on spectral indices and stepwise multiple regression models. Predict_Chla.zip:This file provides the predicted values of Chlorophyll-a for each sensor based on spectral indices and stepwise multiple regression models
DOI: 10.26179/5qyn-xf50
title: A 2000-year temperature reconstruction on the East Antarctic plateau, from argon-nitrogen and water stable isotopes in the Aurora Basin North ice core
DOI: 10.4227/05/57f4aa7197aa4
title: Wirilda-Callitris-Eucalyptus Mallee Low Open Grassy Woodland, SA. Ver. 1. VAST-2: Tracking the Transformation of Australia's Vegetated Landscapes. Australian Centre for Ecological Analysis and Synthesis, University of Queensland, Brisbane
DOI: 10.6084/m9.figshare.16556421
title: Classification of online misleading oral health information

description: A supplementary file of the manuscript: "Exploring online misleading oral health misinformation: a content analysis"
DOI: 10.6084/m9.figshare.16556421.v2
title: Classification of online misleading oral health information

description: A supplementary file of the manuscript: "Exploring online misleading oral health misinformation: a content analysis"
DOI: 10.6084/m9.figshare.16556421.v1
title: Classification of online misleading oral health information

description: A supplementary file of the manuscript: "Exploring online misleading oral health information: a content analysis"
DOI: 10.26179/z2zn-j090
title: Cetacean acoustic presence by species: TEMPO 2021 Sonobuoys
DOI: 10.25911/9e5h-6h87
title: Arabidopsis TR0036 - Phenotyping imaging data
title: Arabidopsis TR0036

description: Experiment ID: BVZ0036 Chamber(s)/Location: GC02, GC05