cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26798285.v1
title: Prophylactic norepinephrine infusion to treat hypotension after spinal anaesthesia during caesarean section: a meta-analysis

description: Spinal anaesthesia is a common anaesthetic method for caesarean sections but often results in hypotension, posing potential risks to maternal and neonatal health. Norepinephrine, as a vasopressor, may be effective in preventing and treating this hypotension. This systematic review and meta-analysis aims to systematically evaluate the efficacy and safety of prophylactic norepinephrine infusion for the treatment of hypotension following spinal anaesthesia in caesarean sections. Literature searches were conducted in PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang, and VIP databases for relevant studies on prophylactic administration of norepinephrine for the treatment of hypotension after spinal anaesthesia in caesarean delivery. Reference lists of included articles were also searched. The latest search update was on March 20, 2024. Meta-analysis was conducted using R software. The methods recommended by the Cochrane Handbook, Begge’s and Egger’s tests were used for risk of bias evaluation of the included literature. Nine studies were finally included in this study. The results showed that prophylactic administration of norepinephrine was superior to the control group in four aspects of treating hypotension after spinal anaesthesia in caesarean delivery: the incidence of hypotension was reduced [RR = 0.34, 95%CI (0.27–0.43), <i>P</i> &lt; 0.01]; the incidence of severe hypotension was reduced [RR = 0.32, 95%CI (0.21–0.51), <i>P</i> &lt; 0.01]; and maternal blood pressure was more stable with MDPE [MD = –5.00, 95%CI (–7.80–−2.21), <i>P =</i> 0.06] and MDAPE [MD = 4.11, 95%CI (1.38–6.85), <i>P</i> &lt; 0.05], the incidence of nausea and vomiting was reduced [RR = 0.52, 95%CI (0.35–0.77), <i>P</i> &lt; 0.01]. On the other hand, the incidence of reactive hypertension was higher than the control group [RR = 3.58, 95%CI (1.94–6.58), <i>P</i> &lt; 0.01]. There was no difference between the two groups in one aspects: newborn Apgar scores [MD = –0.01, 95%CI (–0.10–0.09, <i>P</i> = 0.85)]. Prophylactic administration of norepinephrine is effective in treating hypotension after spinal anaesthesia in caesarean delivery patients; however, it does not provide improved safety and carries a risk of inducing reactive hypertension. Hypotension, or low blood pressure, after spinal anaesthesia can threaten the health of both mothers and their babies during caesarean sections. Norepinephrine is a drug that affects heart rate less and does not easily cross the placental barrier, which may reduce its potential negative effects on the baby. However, there are not many studies on using norepinephrine as a preventive measure. Our study systematically evaluated the use of prophylactic norepinephrine infusion to prevent hypotension in caesarean section patients. We found that it is effective in preventing low blood pressure but does not show improved safety and carries some risk of causing high pressure as a reaction.
DOI: 10.57745/lpm3jg
title: Intercropping_In_row_A12_20240321_155024_mask.png

description: :unav
DOI: 10.57745/qymp1m
title: Intercropping_In_row_REDN11_20240422_161247_mask.png

description: :unav
DOI: 10.6084/m9.figshare.27188531
title: The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers

description: Preeclampsia is still a disease whose cause and treatment have not been fully characterised. Early-onset preeclampsia occurs before the 34th week of pregnancy, and late-onset preeclampsia occurs at 34 weeks or older. In our study, we investigated whether the prognostic nutritional index (PNI) and pan immune inflammation value (PIV), which are used in the prognosis and prediction of diseases in new studies in the literature, are useful for predicting early-onset preeclampsia. The first group consisted of healthy pregnant women who had a single foetus without any additional disease between 24 and 34 gestational weeks, and the second group consisted of pregnant women who were diagnosed with early-onset preeclampsia and did not have any additional disease or foetal anomalies during the same gestational week. Neutrophil, lymphocyte, monocyte, thrombocyte, ALB, pan immune inflammation value (PIV) and prognostic nutritional index (PNI) scores were recorded. In our case control study, 70 patients with early-onset preeclampsia and 140 pregnant women composed the normotensive (control) group. There was a significant difference between the groups according to PIV (p = 0.04). The prognostic nutritional index (PNI) was significantly lower in the early-onset preeclampsia group than in the normotensive group (p &lt; 0,001). A PNI lower than 36, 30 could only predict early-onset preeclampsia with a low sensitivity of 31.1% and specificity of 45%; the area under the curve was 0,24 (95% confidence interval 0.18–0.31), <i>p</i> &lt; 0,001. Patients with PNI scores lower than 36,30 may have early-onset preeclampsia. Preeclampsia, often referred to as pregnancy poisoning, is a condition that is life-threatening to the mother and baby. It typically develops after the 20th week of pregnancy and is characterised by high blood pressure and deterioration in blood values. Preeclampsia comes in two forms: early and late. The early form occurs before the 34th week and tends to be more severe than the late form, causing narrowing of the vessels supplying the baby, decreased blood flow, and delayed foetal development. The late form commonly appears after the 34th week and is usually milder. Since the early form carries a higher risk and often requires premature delivery of the foetus or termination of the pregnancy, studies are being conducted on its prevention and treatment. This study aimed to investigate the differences in blood parameters between patients with early-onset preeclampsia and pregnant women with normal blood pressure and to assess for differences between both groups.
DOI: 10.6084/m9.figshare.27188531.v1
title: The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers

description: Preeclampsia is still a disease whose cause and treatment have not been fully characterised. Early-onset preeclampsia occurs before the 34th week of pregnancy, and late-onset preeclampsia occurs at 34 weeks or older. In our study, we investigated whether the prognostic nutritional index (PNI) and pan immune inflammation value (PIV), which are used in the prognosis and prediction of diseases in new studies in the literature, are useful for predicting early-onset preeclampsia. The first group consisted of healthy pregnant women who had a single foetus without any additional disease between 24 and 34 gestational weeks, and the second group consisted of pregnant women who were diagnosed with early-onset preeclampsia and did not have any additional disease or foetal anomalies during the same gestational week. Neutrophil, lymphocyte, monocyte, thrombocyte, ALB, pan immune inflammation value (PIV) and prognostic nutritional index (PNI) scores were recorded. In our case control study, 70 patients with early-onset preeclampsia and 140 pregnant women composed the normotensive (control) group. There was a significant difference between the groups according to PIV (p = 0.04). The prognostic nutritional index (PNI) was significantly lower in the early-onset preeclampsia group than in the normotensive group (p &lt; 0,001). A PNI lower than 36, 30 could only predict early-onset preeclampsia with a low sensitivity of 31.1% and specificity of 45%; the area under the curve was 0,24 (95% confidence interval 0.18–0.31), <i>p</i> &lt; 0,001. Patients with PNI scores lower than 36,30 may have early-onset preeclampsia. Preeclampsia, often referred to as pregnancy poisoning, is a condition that is life-threatening to the mother and baby. It typically develops after the 20th week of pregnancy and is characterised by high blood pressure and deterioration in blood values. Preeclampsia comes in two forms: early and late. The early form occurs before the 34th week and tends to be more severe than the late form, causing narrowing of the vessels supplying the baby, decreased blood flow, and delayed foetal development. The late form commonly appears after the 34th week and is usually milder. Since the early form carries a higher risk and often requires premature delivery of the foetus or termination of the pregnancy, studies are being conducted on its prevention and treatment. This study aimed to investigate the differences in blood parameters between patients with early-onset preeclampsia and pregnant women with normal blood pressure and to assess for differences between both groups.
DOI: 10.57745/s6it1i
title: Pure_tri_0N_REDN11_20240422_152835.jpg

description: :unav
DOI: 10.57745/h0jpvn
title: Pure_Tri_0N_A12_20240321_144531.jpg

description: :unav
DOI: 10.6084/m9.figshare.27268349
title: Application of WeChat-based cognitive behavioural stress management for early-stage cervical cancer patients: a randomised controlled study

description: This randomised controlled study was aimed at investigating the effects of WeChat-based cognitive behavioural stress management (WB-CBSM) on the mental health of patients with early-stage cervical cancer treated with surgical resection. A total of 184 patients with early-stage cervical cancer were randomised to receive either WB-CBSM (<i>n</i> = 92) or normal care (NC) (<i>n</i> = 92) for 8 weeks. Compared with the NC group, the WB-CBSM group exhibited reduced Hospital Anxiety and Depression Scale (HADS)–anxiety scores at months (M)1 (<i>t</i> = 2.022, <i>P</i> = 0.045), M3 (<i>t</i> = 2.575, <i>P</i> = 0.011), and M6 (<i>t</i> = 2.709, <i>P</i> = 0.007); anxiety rates at M3 (<i>χ<sup>2</sup></i> = 4.834, <i>P</i> = 0.028) and M6 (<i>χ<sup>2</sup></i> = 5.182, <i>P</i> = 0.023); HADS–depression scores at M3 (<i>t</i> = 2.069, <i>P</i> = 0.040) and M6 (<i>t</i> = 2.449, <i>P</i> = 0.015); and depression rates at M6 (<i>χ<sup>2</sup></i> = 4.268, <i>P</i> = 0.039). Moreover, the WB-CBSM group showed increased Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being scale scores at M1 (<i>t</i> = −2.001, <i>P</i> = 0.047), M3 (<i>t</i> = −2.281, <i>P</i> = 0.024), and M6 (<i>t</i> = −3.501, <i>P</i> = 0.001); the Quality of Life Questionnaire-Core 30 (QLQ-C30) global health score at M3 (<i>t</i> = −2.034, <i>P</i> = 0.043) and M6 (<i>t</i> = −2.426, <i>P</i> = 0.016); and QLQ-C30 function score at M3 (<i>t</i> = −2.009, <i>P</i> = 0.046). However, the groups exhibited decreased EuroQol-5 dimension scores at M3 (<i>t</i> = 2.056, <i>P</i> = 0.041) and M6 ((<i>t</i> = 2.242, <i>P</i> = 0.026) and QLQ-C30 symptom scores at M1 (<i>t</i> = 2.026, <i>P</i> = 0.044) and M3 (<i>t</i> = 2.210, <i>P</i> = 0.028). WB-CBSM reduced anxiety and depression and improved the spiritual well-being and quality of life of patients with early-stage cervical cancer treated with surgical resection. Patients with cervical cancer usually need to cope with mental health problems after surgery due to physical recovery and lack of social communication. Effective nursing care is thus essential for these patients. This study included 184 patients with early-stage cervical cancer who underwent surgical resections. Patients were randomised to receive WeChat-based cognitive behavioural stress management (WB-CBSM) (<i>n</i> = 92) or normal care (NC) (<i>n</i> = 92) for 8 weeks. WB-CBSM decreased anxiety scores at month (M) 1, M3, and M6; it also reduced depression scores at M3 and M6 compared with NC. Moreover, WB-CBSM increased spiritual well-being at M1, M3, and M6 and improved quality of life from the aspects of global health at M3 and M6, function at M3, and symptoms at M1 and M3. In summary, WB-CBSM improves psychological health and quality of life of patients with early-stage cervical cancer treated with surgical resection.
DOI: 10.6084/m9.figshare.27268349.v1
title: Application of WeChat-based cognitive behavioural stress management for early-stage cervical cancer patients: a randomised controlled study

description: This randomised controlled study was aimed at investigating the effects of WeChat-based cognitive behavioural stress management (WB-CBSM) on the mental health of patients with early-stage cervical cancer treated with surgical resection. A total of 184 patients with early-stage cervical cancer were randomised to receive either WB-CBSM (<i>n</i> = 92) or normal care (NC) (<i>n</i> = 92) for 8 weeks. Compared with the NC group, the WB-CBSM group exhibited reduced Hospital Anxiety and Depression Scale (HADS)–anxiety scores at months (M)1 (<i>t</i> = 2.022, <i>P</i> = 0.045), M3 (<i>t</i> = 2.575, <i>P</i> = 0.011), and M6 (<i>t</i> = 2.709, <i>P</i> = 0.007); anxiety rates at M3 (<i>χ<sup>2</sup></i> = 4.834, <i>P</i> = 0.028) and M6 (<i>χ<sup>2</sup></i> = 5.182, <i>P</i> = 0.023); HADS–depression scores at M3 (<i>t</i> = 2.069, <i>P</i> = 0.040) and M6 (<i>t</i> = 2.449, <i>P</i> = 0.015); and depression rates at M6 (<i>χ<sup>2</sup></i> = 4.268, <i>P</i> = 0.039). Moreover, the WB-CBSM group showed increased Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being scale scores at M1 (<i>t</i> = −2.001, <i>P</i> = 0.047), M3 (<i>t</i> = −2.281, <i>P</i> = 0.024), and M6 (<i>t</i> = −3.501, <i>P</i> = 0.001); the Quality of Life Questionnaire-Core 30 (QLQ-C30) global health score at M3 (<i>t</i> = −2.034, <i>P</i> = 0.043) and M6 (<i>t</i> = −2.426, <i>P</i> = 0.016); and QLQ-C30 function score at M3 (<i>t</i> = −2.009, <i>P</i> = 0.046). However, the groups exhibited decreased EuroQol-5 dimension scores at M3 (<i>t</i> = 2.056, <i>P</i> = 0.041) and M6 ((<i>t</i> = 2.242, <i>P</i> = 0.026) and QLQ-C30 symptom scores at M1 (<i>t</i> = 2.026, <i>P</i> = 0.044) and M3 (<i>t</i> = 2.210, <i>P</i> = 0.028). WB-CBSM reduced anxiety and depression and improved the spiritual well-being and quality of life of patients with early-stage cervical cancer treated with surgical resection. Patients with cervical cancer usually need to cope with mental health problems after surgery due to physical recovery and lack of social communication. Effective nursing care is thus essential for these patients. This study included 184 patients with early-stage cervical cancer who underwent surgical resections. Patients were randomised to receive WeChat-based cognitive behavioural stress management (WB-CBSM) (<i>n</i> = 92) or normal care (NC) (<i>n</i> = 92) for 8 weeks. WB-CBSM decreased anxiety scores at month (M) 1, M3, and M6; it also reduced depression scores at M3 and M6 compared with NC. Moreover, WB-CBSM increased spiritual well-being at M1, M3, and M6 and improved quality of life from the aspects of global health at M3 and M6, function at M3, and symptoms at M1 and M3. In summary, WB-CBSM improves psychological health and quality of life of patients with early-stage cervical cancer treated with surgical resection.
DOI: 10.57745/dpkj6f
title: Pure_Faba_HUAP30_20240408_151930_mask.png

description: :unav
DOI: 10.57745/9so0bl
title: Pure_tri_0N_REDN11_20240321_143630.jpg

description: :unav
DOI: 10.6084/m9.figshare.25323198
title: Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis

description: This study aimed to investigate the potential role of ferroptosis/hypoxia-related genes in cervical cancer to improve early management and treatment of cervical cancer. All data were downloaded from public databases. Ferroptosis/hypoxia-related genes associated with cervical cancer prognosis were selected to construct a risk score model. The relationship between risk score and clinical features, immune microenvironment and prognosis were analysed. Risk score model was constructed based on eight signature genes. Drug prediction analysis showed that bevacizumab and cisplatin were related to vascular endothelial growth factor A. Risk score, as an independent prognostic factor of cervical cancer, had a good survival prediction effect. The two groups differed significantly in degree of immune cell infiltration, gene expression, tumour mutation burden and somatic variation. We developed a novel prognostic gene signature combining ferroptosis/hypoxia-related genes, which provides new ideas for individual treatment of cervical cancer. Ferroptosis, hypoxia and immune regulation play important roles in cervical cancer progression. In this study, we developed a novel prognostic signature combining ferroptosis and hypoxia-related genes, which provides new ideas for individual treatment of cervical cancer patients. The risk score established by ferroptosis and hypoxia-related gene as an independent prognostic factor of cervical cancer has a good survival prediction effect. High and low risk groups showed significant differences in TIME, prognosis, biological metabolic pathway and tumour mutation burden. In addition, we found drugs associated with signature genes. In short, this study has laid a theoretical foundation for exploring the related molecular mechanisms and prognosis of cervical cancer. It also contributes to the exploration of clinical management and treatment.
DOI: 10.6084/m9.figshare.25323198.v1
title: Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis

description: This study aimed to investigate the potential role of ferroptosis/hypoxia-related genes in cervical cancer to improve early management and treatment of cervical cancer. All data were downloaded from public databases. Ferroptosis/hypoxia-related genes associated with cervical cancer prognosis were selected to construct a risk score model. The relationship between risk score and clinical features, immune microenvironment and prognosis were analysed. Risk score model was constructed based on eight signature genes. Drug prediction analysis showed that bevacizumab and cisplatin were related to vascular endothelial growth factor A. Risk score, as an independent prognostic factor of cervical cancer, had a good survival prediction effect. The two groups differed significantly in degree of immune cell infiltration, gene expression, tumour mutation burden and somatic variation. We developed a novel prognostic gene signature combining ferroptosis/hypoxia-related genes, which provides new ideas for individual treatment of cervical cancer. Ferroptosis, hypoxia and immune regulation play important roles in cervical cancer progression. In this study, we developed a novel prognostic signature combining ferroptosis and hypoxia-related genes, which provides new ideas for individual treatment of cervical cancer patients. The risk score established by ferroptosis and hypoxia-related gene as an independent prognostic factor of cervical cancer has a good survival prediction effect. High and low risk groups showed significant differences in TIME, prognosis, biological metabolic pathway and tumour mutation burden. In addition, we found drugs associated with signature genes. In short, this study has laid a theoretical foundation for exploring the related molecular mechanisms and prognosis of cervical cancer. It also contributes to the exploration of clinical management and treatment.
DOI: 10.57745/3zkydc
title: Intercropping_Mixed_REDN4_20240321_155455.jpg

description: :unav
DOI: 10.6084/m9.figshare.25288064
title: Impact of haemostasis methods during ovarian cystectomy on ovarian reserve: a pairwise and network meta-analysis

description: Haemostasis during ovarian cystectomy is reported to damage the ovarian reserve, but the comparative impacts of three haemostasis methods (bipolar energy, suture and haemostatic sealant) on ovarian reserve in patients with ovarian cysts are not well known. The Cochrane Library, PubMed and Web of Science databases were searched from the date of inception of the database to June 2022 for literature exploring the impact of haemostasis methods during ovarian cystectomy on ovarian reserve. A traditional meta-analysis was performed using Review Manager software. A network meta-analysis (NMA) was performed using Stata and GemTC software. The direct meta-analysis comparison indicated that the mean postoperative reduction of anti-Müllerian hormone (AMH) level was significantly higher in the electrocoagulation (bipolar) group than suture and haemostatic sealant group, both in the overall group and subgroup of women with ovarian endometrioma. In NMA, the reduction of postoperative AMH levels in the electrocoagulation (bipolar) group was higher than the suture group at 6 months with a statistical significance, and at 1, 3 and 12 months without a significant difference. The difference in the postoperative decrease of AMH level did not reach statistical significance between suture and sealant, coagulation and haemostatic sealant. The comprehensive ranking results revealed that suture treatment was, with the highest probability, beneficial to the protection of the ovarian reserve. There was insufficient research to detect the optimal haemostasis method for ovarian reserve preservation in ovarian cystectomy. Nevertheless, haemostasis by electrocoagulation (bipolar) should be avoided when possible, and the suture might be considered as the best choice. Haemostasis during ovarian cystectomy is reported to damage the ovarian reserve, but the comparative impacts of three haemostasis methods (bipolar energy, suture and haemostatic sealant) on ovarian reserve in patients with ovarian cysts are not well known. The level of AMH is the most widely used surrogate for ovarian reserve. Our research compared the impact of three haemostasis methods (electrocoagulation, suture and haemostatic sealant) on changes in the levels of anti-Müllerian hormone at 1, 3, 6 and 12 month(s) after the operation. The outcomes revealed that there was insufficient research to detect the optimal haemostasis method for ovarian preservation in ovarian cystectomy. Nevertheless, haemostasis by electrocoagulation (bipolar) should be avoided when possible, and the suture might be considered as the best choice.