cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.3zkqh5
title: Occurrence Download

description: A dataset containing 74899 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Oenothera biennis L."
 ]
}

 The dataset includes 74899 records from 1323 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0052785-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.3843405.v3
title: Structural brain development during adolescence and its relation to psychiatric disorders

description: Adolescence is a period of human brain growth and high incidence of mental health disorders. I will present my work within the Neuroscience in Psychiatry Network (NSPN; www.nspn.org.uk) on cortical myelination between the ages of 14 and 24. I will show show, consistently in two cohorts, that age-related changes in adolescence are concentrated on the more densely connected hubs of the human structural connectome. I will demonstrate the power of integrating open data sets such as the Allen Brain Atlas with non-invasive imaging techniques: specifically by linking the expression of schizophrenia risk genes to adolescent brain development.
DOI: 10.7910/dvn/v1rjpf/acexhz
title: mea20161105_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843387.v1
title: Differential expressed analysis of <i>Tripterygium wilfordii</i> unigenes involved in terpenoid backbone biosynthesis

description: <i>Tripterygium wilfordii</i> Hook. f. is the traditional medicinal plants in China. Triptolide, wilforgine, and wilforine are the bioactive compounds in <i>T. wilfordii.</i> In this study, the contents of three metabolites and transcription levels of 21 genes involved in three metabolites biosynthesis in <i>T. wilfordii</i> were examined using high-performance liquid chromatography and reverse transcription PCR after application of methyl jasmonate (MeJA) on hairy roots in time course experiment (3–24 h). The results indicated that application of MeJA inhibited triptolide accumulation and promoted wilforgine and wilforine metabolites biosynthesis. In hairy roots, wilforgine content reached 693.36 μg/g at 6 h after adding MeJA, which was 2.23-fold higher than control. The accumulation of triptolide and wilforine in hairy roots increased the maximum at 9 h, which was 1.3- and 1.6-folds more than the control. Most of the triptolide secretes into the medium, but wilforgine and wilforine cannot secrete into the medium. The expression levels of unigenes which involved terpenoid backbone biosynthesis exist the correlation with marker metabolites (triptolide, wilforgine and wilforine) after induction by MeJA, and can be then used to infer flux bottlenecks in <i>T. wilfordii</i> secondary metabolites accumulation. These results showed that these genes may have potential applications in the metabolic engineering of <i>T. wilfordii</i> metabolites production.
DOI: 10.7910/dvn/v1rjpf/sor6h1
title: mea20151129_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/2gaw52
title: mea20150524_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/114oyy
title: mea20151013_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843372
title: Assessing microstructural substrates of white matter abnormalities: a comparative study using DTI and NODDI

description: This dataset includes the mean output scalar files (mean_FA/RD/AD/TR/NDI/ODI/fiso), plus the relevant statistical maps, all in nii format. This allows one to inspect and visualize the statistics on which the results are based on. It also included a READ ME text file for more information the data.
DOI: 10.6084/m9.figshare.3843378
title: Repeated courses of intratympanic dexamethasone injection are effective for intractable Meniere’s disease

description: <b>Conclusion:</b> Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere’s disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. <b>Objectives:</b> This study examined the effect of repeated courses of ITD administered on demand and investigated the possibility of ITD as an initial IT treatment for medically intractable MD patients. <b>Method:</b> Fifty-one patients who had been diagnosed with definite MD and given course(s) of ITD treatment were included. Vertigo control, pure tone average and functional disability scores were evaluated against the American Academy of Otolaryngology-Head and Neck Surgery guidelines for MD. <b>Results:</b> Vertigo disappeared or was substantially controlled in 58.8% and 23.5% of the patients, respectively, after the first ITD course. A repeated course further raised the complete vertigo control rate by 15.7% and intra-tympanic gentamycin injection could be postponed or avoided in 78.6% of the patients who required repeated IT treatment. Hearing was unchanged after the first course of ITD (<i>p</i> &gt; .05). No significant differences were detected in the clinical profiles or laboratory findings between patients receiving single course of ITD and those on multiple courses (<i>p</i> &gt; .05).
DOI: 10.7910/dvn/v1rjpf/xrbl7o
title: mea20151127_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843372.v1
title: Assessing microstructural substrates of white matter abnormalities: a comparative study using DTI and NODDI

description: This dataset includes the mean output scalar files (mean_FA/RD/AD/TR/NDI/ODI/fiso), plus the relevant statistical maps, all in nii format. This allows one to inspect and visualize the statistics on which the results are based on. It also included a READ ME text file for more information the data.
DOI: 10.6084/m9.figshare.3843378.v1
title: Repeated courses of intratympanic dexamethasone injection are effective for intractable Meniere’s disease

description: <b>Conclusion:</b> Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere’s disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. <b>Objectives:</b> This study examined the effect of repeated courses of ITD administered on demand and investigated the possibility of ITD as an initial IT treatment for medically intractable MD patients. <b>Method:</b> Fifty-one patients who had been diagnosed with definite MD and given course(s) of ITD treatment were included. Vertigo control, pure tone average and functional disability scores were evaluated against the American Academy of Otolaryngology-Head and Neck Surgery guidelines for MD. <b>Results:</b> Vertigo disappeared or was substantially controlled in 58.8% and 23.5% of the patients, respectively, after the first ITD course. A repeated course further raised the complete vertigo control rate by 15.7% and intra-tympanic gentamycin injection could be postponed or avoided in 78.6% of the patients who required repeated IT treatment. Hearing was unchanged after the first course of ITD (<i>p</i> &gt; .05). No significant differences were detected in the clinical profiles or laboratory findings between patients receiving single course of ITD and those on multiple courses (<i>p</i> &gt; .05).
DOI: 10.6084/m9.figshare.3843366
title: Table 1. Controls on the apex location of large deltas

description: Calculation of hydrodynamic backwater length for 13 rivers.
DOI: 10.6084/m9.figshare.3843369
title: Table 2. Controls on the apex location of large deltas

description: Apex type for studied deltas
DOI: 10.7910/dvn/v1rjpf/6vkgts
title: mea20160911_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843366.v1
title: Table 1. Controls on the apex location of large deltas

description: Calculation of hydrodynamic backwater length for 13 rivers.
DOI: 10.6084/m9.figshare.3843369.v1
title: Table 2. Controls on the apex location of large deltas

description: Apex type for studied deltas
DOI: 10.7910/dvn/v1rjpf/whwl0i
title: mea20161109_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843360
title: ankit_wjpps_(IF-2.78).pdf

description: Diabetes affects 12% of the total population in world. So it is very<br>important to treat this fatal disease. There are many marketed<br>preparation is available to treat diabetes but not a single medicine have<br>the ability to cure it. A thirst in research area is more and more<br>increased now a day. Novel pathways and targets are identified in<br>current time that may be kill this dragon named diabetes. Inhibition of<br>a novel target PTP1B is chosen for attack on diabetes. PTP1B<br>inhibition reported as negative regulator of insulin signaling pathway<br>which increased the insulin sensitivity on insulin receptor. The<br>numerous scaffold are reported and still so much research task going<br>on for PTP1B inhibition. We choose Hydantoin scaffold as novel<br>inhibition of PTP1B and design molecule that binds with this enzyme<br>and inhibit it. A series of substituted 2-[4-[(2,5-dioxo imidazolidin-4- ylidene) methyl]<br>Aryloxy] -N-arylacetamide is decided to synthesized. The inhibition of PTP1B is in vitro<br>tested over PTP1B enzymatic kit. Among all the tested compounds, two compound were<br>found most potent activity 90.59% & 97.56 % inhibition respecively (N-(4-bromophenyl)-2-<br>[4-[(2,5- dioxoimidazolidin-4-ylidene)methyl] phenoxy]acetamides) and (2-[[2-[4-[(2,5-dioxoimidazolidin-4-ylidene)methyl] phenoxy] acetyl]amino]benzoic acid) with compared to<br>standard drug suramin.
DOI: 10.6084/m9.figshare.3843360.v1
title: ankit_wjpps_(IF-2.78).pdf

description: Diabetes affects 12% of the total population in world. So it is very<br>important to treat this fatal disease. There are many marketed<br>preparation is available to treat diabetes but not a single medicine have<br>the ability to cure it. A thirst in research area is more and more<br>increased now a day. Novel pathways and targets are identified in<br>current time that may be kill this dragon named diabetes. Inhibition of<br>a novel target PTP1B is chosen for attack on diabetes. PTP1B<br>inhibition reported as negative regulator of insulin signaling pathway<br>which increased the insulin sensitivity on insulin receptor. The<br>numerous scaffold are reported and still so much research task going<br>on for PTP1B inhibition. We choose Hydantoin scaffold as novel<br>inhibition of PTP1B and design molecule that binds with this enzyme<br>and inhibit it. A series of substituted 2-[4-[(2,5-dioxo imidazolidin-4- ylidene) methyl]<br>Aryloxy] -N-arylacetamide is decided to synthesized. The inhibition of PTP1B is in vitro<br>tested over PTP1B enzymatic kit. Among all the tested compounds, two compound were<br>found most potent activity 90.59% & 97.56 % inhibition respecively (N-(4-bromophenyl)-2-<br>[4-[(2,5- dioxoimidazolidin-4-ylidene)methyl] phenoxy]acetamides) and (2-[[2-[4-[(2,5-dioxoimidazolidin-4-ylidene)methyl] phenoxy] acetyl]amino]benzoic acid) with compared to<br>standard drug suramin.
DOI: 10.7910/dvn/v1rjpf/8fcdp3
title: mea20161014_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/cidbkp
title: mea20150727_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843342
title: Behavioral data from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Prominent theories emphasize key roles for the insular cortex in the central representation of interoceptive sensations, but how this brain region responds dynamically to changes in interoceptive state remains incompletely understood. Here, we systematically modulated cardiorespiratory sensations in humans using bolus infusions of isoproterenol, a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline. To identify central neural processes underlying these parametrically modulated interoceptive states, we used pharmacological functional magnetic resonance imaging (phMRI) to simultaneously measure blood-oxygenation-level dependent (BOLD) and arterial spin labelling (ASL) signals in healthy participants. Isoproterenol infusions induced dose-dependent increases in heart rate and cardiorespiratory interoception, with all participants endorsing increased sensations at the highest dose. These reports were accompanied by increased BOLD and ASL activation of the right insular cortex at the highest dose. Different responses across insula subregions were also observed. During anticipation, insula activation increased in more anterior regions. During stimulation, activation increased in the mid-dorsal and posterior insula on the right, but decreased in the same regions on the left. This study demonstrates the feasibility of phMRI for assessing brain activation during adrenergic interoceptive stimulation, and provides further evidence supporting a dynamic role for the insula in representing changes in cardiorespiratory states.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.7910/dvn/v1rjpf/spn8f3
title: mea20160314_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843342.v1
title: Behavioral data from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Prominent theories emphasize key roles for the insular cortex in the central representation of interoceptive sensations, but how this brain region responds dynamically to changes in interoceptive state remains incompletely understood. Here, we systematically modulated cardiorespiratory sensations in humans using bolus infusions of isoproterenol, a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline. To identify central neural processes underlying these parametrically modulated interoceptive states, we used pharmacological functional magnetic resonance imaging (phMRI) to simultaneously measure blood-oxygenation-level dependent (BOLD) and arterial spin labelling (ASL) signals in healthy participants. Isoproterenol infusions induced dose-dependent increases in heart rate and cardiorespiratory interoception, with all participants endorsing increased sensations at the highest dose. These reports were accompanied by increased BOLD and ASL activation of the right insular cortex at the highest dose. Different responses across insula subregions were also observed. During anticipation, insula activation increased in more anterior regions. During stimulation, activation increased in the mid-dorsal and posterior insula on the right, but decreased in the same regions on the left. This study demonstrates the feasibility of phMRI for assessing brain activation during adrenergic interoceptive stimulation, and provides further evidence supporting a dynamic role for the insula in representing changes in cardiorespiratory states.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.6084/m9.figshare.3843339
title: Functional MRI data in MATLAB file format for BOLD from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Includes 4 variables: 1) Anticipation_vs_Baseline_Contrast; 2) Peak_vs_Baseline_Contrast; 3) Recovery_vs_Baseline_Contrast; 4) Dose_Order. Variables 1 to 3 are contrast maps built by subtracting the BOLD signal averaged over the baseline block (as defined in the text) from the BOLD signal averaged across anticipatory, peak and recovery blocks, respectively (as defined in the text). The contrast maps have 5 dimensions and include data for 21 subjects (second dimension) and 4 doses (first dimension), dimension 3-5 are x, y and z directions (91x109 x91 voxels), respectively. Dose orders in these data follow the order given in Dose_Order variable
DOI: 10.7910/dvn/v1rjpf/we5lyg
title: mea20151103_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843339.v1
title: Functional MRI data in MATLAB file format for BOLD from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Includes 4 variables: 1) Anticipation_vs_Baseline_Contrast; 2) Peak_vs_Baseline_Contrast; 3) Recovery_vs_Baseline_Contrast; 4) Dose_Order. Variables 1 to 3 are contrast maps built by subtracting the BOLD signal averaged over the baseline block (as defined in the text) from the BOLD signal averaged across anticipatory, peak and recovery blocks, respectively (as defined in the text). The contrast maps have 5 dimensions and include data for 21 subjects (second dimension) and 4 doses (first dimension), dimension 3-5 are x, y and z directions (91x109 x91 voxels), respectively. Dose orders in these data follow the order given in Dose_Order variable
DOI: 10.7910/dvn/v1rjpf/z757ky
title: mea20150119_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/mg0xf2
title: mea20161115_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843327
title: Functional MRI data in MATLAB file format for ASL from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Includes 4 variables: 1) Anticipation_vs_Baseline_Contrast; 2) Peak_vs_Baseline_Contrast; 3) Recovery_vs_Baseline_Contrast; 4) Dose_Order. Variables 1 to 3 are contrast maps built by subtracting the ASL signal averaged over the baseline block (as defined in the text) from the ASL signal averaged across anticipatory, peak and recovery blocks, respectively (as defined in the text). The contrast maps have 5 dimensions and include data for 21 subjects (second dimension) and 4 doses (first dimension), dimension 3-5 are x, y and z directions (91x109 x91 voxels), respectively. Dose orders in these data follow the order given in Dose_Order variable
DOI: 10.7910/dvn/v1rjpf/nj1ii0
title: mea20150723_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843324
title: Functional MRI data in MATLAB file format for BOLD; Functional MRI data in MATLAB file format for ASL; Contrast maps and weighted atlas map from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Prominent theories emphasize key roles for the insular cortex in the central representation of interoceptive sensations, but how this brain region responds dynamically to changes in interoceptive state remains incompletely understood. Here, we systematically modulated cardiorespiratory sensations in humans using bolus infusions of isoproterenol, a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline. To identify central neural processes underlying these parametrically modulated interoceptive states, we used pharmacological functional magnetic resonance imaging (phMRI) to simultaneously measure blood-oxygenation-level dependent (BOLD) and arterial spin labelling (ASL) signals in healthy participants. Isoproterenol infusions induced dose-dependent increases in heart rate and cardiorespiratory interoception, with all participants endorsing increased sensations at the highest dose. These reports were accompanied by increased BOLD and ASL activation of the right insular cortex at the highest dose. Different responses across insula subregions were also observed. During anticipation, insula activation increased in more anterior regions. During stimulation, activation increased in the mid-dorsal and posterior insula on the right, but decreased in the same regions on the left. This study demonstrates the feasibility of phMRI for assessing brain activation during adrenergic interoceptive stimulation, and provides further evidence supporting a dynamic role for the insula in representing changes in cardiorespiratory states.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.6084/m9.figshare.3843327.v1
title: Functional MRI data in MATLAB file format for ASL from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Includes 4 variables: 1) Anticipation_vs_Baseline_Contrast; 2) Peak_vs_Baseline_Contrast; 3) Recovery_vs_Baseline_Contrast; 4) Dose_Order. Variables 1 to 3 are contrast maps built by subtracting the ASL signal averaged over the baseline block (as defined in the text) from the ASL signal averaged across anticipatory, peak and recovery blocks, respectively (as defined in the text). The contrast maps have 5 dimensions and include data for 21 subjects (second dimension) and 4 doses (first dimension), dimension 3-5 are x, y and z directions (91x109 x91 voxels), respectively. Dose orders in these data follow the order given in Dose_Order variable
DOI: 10.7910/dvn/v1rjpf/yqzbli
title: mea20150523_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3843324.v1
title: Functional MRI data in MATLAB file format for BOLD; Functional MRI data in MATLAB file format for ASL; Contrast maps and weighted atlas map from How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation

description: Prominent theories emphasize key roles for the insular cortex in the central representation of interoceptive sensations, but how this brain region responds dynamically to changes in interoceptive state remains incompletely understood. Here, we systematically modulated cardiorespiratory sensations in humans using bolus infusions of isoproterenol, a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline. To identify central neural processes underlying these parametrically modulated interoceptive states, we used pharmacological functional magnetic resonance imaging (phMRI) to simultaneously measure blood-oxygenation-level dependent (BOLD) and arterial spin labelling (ASL) signals in healthy participants. Isoproterenol infusions induced dose-dependent increases in heart rate and cardiorespiratory interoception, with all participants endorsing increased sensations at the highest dose. These reports were accompanied by increased BOLD and ASL activation of the right insular cortex at the highest dose. Different responses across insula subregions were also observed. During anticipation, insula activation increased in more anterior regions. During stimulation, activation increased in the mid-dorsal and posterior insula on the right, but decreased in the same regions on the left. This study demonstrates the feasibility of phMRI for assessing brain activation during adrenergic interoceptive stimulation, and provides further evidence supporting a dynamic role for the insula in representing changes in cardiorespiratory states.This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
DOI: 10.7910/dvn/v1rjpf/hmgbol
title: mea20150510_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/g1pl78
title: mea20150607_03.txt.gz

description: :unav