cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3438557
title: ADAR editing detection script and data for DImmSV

description: R script to identify ADAR edits and exclude preferential ADAR editing sites in DImmSV sequences.
DOI: 10.6084/m9.figshare.3438557.v1
title: ADAR editing detection script and data for DImmSV

description: R script to identify ADAR edits and exclude preferential ADAR editing sites in DImmSV sequences.
DOI: 10.6084/m9.figshare.3438413
title: Herbs, ingredients and targets of SWT and SJZT1.rar

description: <b>Traditional Chinese Medicine (TCM) is increasingly getting clinical application worldwide. But its theory like QI-Blood is still abstract. Actually, Qi deficiency and blood deficiency, which were treated by Si-Jun-Zi-Tang (SJZT) and Si-Wu-Tang (SWT) respectively, have characteristic clinical manifestations. Here, we analyzed targets of the ingredients in SJZT and SWT to unveil potential biologic mechanisms between Qi deficiency and blood deficiency through biomedical approaches. First, ingredients in SWT and SJZT were retrieved from TCMID database. The genes targeted by these ingredients were chosen from STITCH. After enrichment analysis by Gene Ontology (GO) and DAVID, enriched GO terms with p-value less than 0.01 were collected and interpreted through DAVID and KEGG. Then a visualized network was constructed with ClueGO. Finally, a total of 243 genes targeted by 195 ingredients of SWT formula and 209 genes targeted by 61 ingredients of SJZT were obtained. Six </b> <b>metabolism pathways and two environmental information processing pathways </b><b>enriched by targets were correlated with two or more herbs in SWT and SJZT formula, respectively. SWT significantly influence amino acid and carbohydrate metabolism. While SJZT mainly influence the organismal system function, environmental information processing, metabolism and cellular processes.</b>
DOI: 10.6084/m9.figshare.3438413.v1
title: Herbs, ingredients and targets of SWT and SJZT1.rar

description: <b>Traditional Chinese Medicine (TCM) is increasingly getting clinical application worldwide. But its theory like QI-Blood is still abstract. Actually, Qi deficiency and blood deficiency, which were treated by Si-Jun-Zi-Tang (SJZT) and Si-Wu-Tang (SWT) respectively, have characteristic clinical manifestations. Here, we analyzed targets of the ingredients in SJZT and SWT to unveil potential biologic mechanisms between Qi deficiency and blood deficiency through biomedical approaches. First, ingredients in SWT and SJZT were retrieved from TCMID database. The genes targeted by these ingredients were chosen from STITCH. After enrichment analysis by Gene Ontology (GO) and DAVID, enriched GO terms with p-value less than 0.01 were collected and interpreted through DAVID and KEGG. Then a visualized network was constructed with ClueGO. Finally, a total of 243 genes targeted by 195 ingredients of SWT formula and 209 genes targeted by 61 ingredients of SJZT were obtained. Six </b> <b>metabolism pathways and two environmental information processing pathways </b><b>enriched by targets were correlated with two or more herbs in SWT and SJZT formula, respectively. SWT significantly influence amino acid and carbohydrate metabolism. While SJZT mainly influence the organismal system function, environmental information processing, metabolism and cellular processes.</b>
DOI: 10.6084/m9.figshare.3438410
title: Political Consulting Expenditures 2012 and 2016

description: Includes expenditures through March 30 of election year by campaign committees and super pacs as well as independent expenditures though May 1
DOI: 10.6084/m9.figshare.3438410.v1
title: Political Consulting Expenditures 2012 and 2016

description: Includes expenditures through March 30 of election year by campaign committees and super pacs as well as independent expenditures though May 1
DOI: 10.6084/m9.figshare.3438392
title: Dressmakers show enhanced stereoscopic vision

description: This is a set of measures for stereovision using psychophysics on a computer with a stereoscope for absolute and relative disparities at two pedestals (5 and 10 arcmin) and using a single stimulus method. The two groups are subjects that are professional dressmakers and non-dressmakers in Geneva.<br>
DOI: 10.6084/m9.figshare.3438392.v1
title: Dressmakers show enhanced stereoscopic vision

description: This is a set of measures for stereovision using psychophysics on a computer with a stereoscope for absolute and relative disparities at two pedestals (5 and 10 arcmin) and using a single stimulus method. The two groups are subjects that are professional dressmakers and non-dressmakers in Geneva.<br>
DOI: 10.6084/m9.figshare.3438371
title: VoCol Evaluation Material

description: VoCol Evaluation Material
DOI: 10.6084/m9.figshare.3438371.v2
title: VoCol Evaluation Material

description: VoCol Evaluation Material
DOI: 10.6084/m9.figshare.3438371.v1
title: VoCol Evaluation Material

description: VoCol Evaluation Material
DOI: 10.6084/m9.figshare.3438362
title: Cis eQTL analysis of SLC2A2 in human liver tissue

description: A three-stage genome wide association study (GWAS) reports the finding of the C-allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (p=6.6x10<sup>-14</sup>) greater metformin induced HbA1c reduction in 10,577 participants of European ancestry (doi:10.1038/ng.3632). The SNP, rs8192675 is the top cis-eQTL for SLC2A2 in 1,226 human liver samples, suggesting a key role for hepatic GLUT2 in regulation of metformin action. Here, we deposit the SLC2A2 transcript levels (see Supplemental Table A) in 583 human liver samples and their genotypes within the SLC2A2 region (see Supplemental Table B). The data here are referred to as data set 4 in the published GWAS (doi:10.1038/ng.3632).
DOI: 10.6084/m9.figshare.3438347
title: Repeatmasker annotation tables

description: These are tab-delimited text files containing the RepeatMasker annotation tables. These tables have been cleaned to remove parentheses from the strand information.
DOI: 10.6084/m9.figshare.3438347.v1
title: Repeatmasker annotation tables

description: These are tab-delimited text files containing the RepeatMasker annotation tables. These tables have been cleaned to remove parentheses from the strand information.
DOI: 10.6084/m9.figshare.3438344
title: Deer simplify vegetation structure and reduce abundance of web-building spiders

description: In this study, we determined whether deer affected assemblages of web-building spiders. We examined web-building spider assemblages with and without deer, using a paired exclosure-control design in two regions of the northern hardwoods forest of the U.S.—the Allegheny Plateau of Pennsylvania and the Northern Highlands of Wisconsin—separated by approximately 1000 km. We surveyed webs and vegetation to determine the degree to which deer alter the abundance and composition of a web-building spider guild.
DOI: 10.6084/m9.figshare.3438344.v1
title: Deer simplify vegetation structure and reduce abundance of web-building spiders

description: In this study, we determined whether deer affected assemblages of web-building spiders. We examined web-building spider assemblages with and without deer, using a paired exclosure-control design in two regions of the northern hardwoods forest of the U.S.—the Allegheny Plateau of Pennsylvania and the Northern Highlands of Wisconsin—separated by approximately 1000 km. We surveyed webs and vegetation to determine the degree to which deer alter the abundance and composition of a web-building spider guild.
DOI: 10.6084/m9.figshare.3438317
title: Edited FASTA alignment of mtDNA sequences from the Western Palaearctic Hyles euphorbiae complex (HEC; Lepidoptera: Sphingidae)

description: Alignment (FASTA format) of partial sequences of mitochondrial genes COI/II and interjacent tRNA-leucine from 889 specimens of the Hyles euphorbiae complex (HEC; Lepidoptera: Sphingidae) from various localities covering virtually its entire Western Palaearctic distribution range (Macaronesia, Maghreb, Europe, Middle East, Western Asia).<br><br>From the original sequences (see Genbank accession numbers in Tab. S1 of the associated publication: Mende et al., 2016, Scientific Reports), base positions with &gt;10 ambiguities in the total alignment were deleted from all sequences and the few remaining ambiguities at non-informative sites were overwritten to the respective base at their particular locus and those at parsimony-informative sites to the most common base of the corresponding haplogroup. The present alignment includes the deleted positions within the sequences ("?") for coherence of the sequence and easy inference of base triplets; all calculations of the associated publication were done without "?" positions. <br><br><br>key to file:<br><br>&gt;XXX- (= abbreviation of pooled populations; corresponds to abbreviations in Figs. 1, 3 and 7 and Tab. S1 of the associated publication)<br><br>#### (= voucher number in the invertebrates tissue catalogue of the Museum für Tierkunde Dresden, Germany; corresponds to column "MTD-TW #" in Tab. S1 of the associated publication)<br><br>NNNNN [= sequence of mitochondrial genes COI (from position 1-1463), tRNA-leucine (1464-1525) and COII (position 1526-2127); ? = data that has been deleted from sequences for calculations due to ambiguities (see above)]
DOI: 10.6084/m9.figshare.3438317.v1
title: Edited FASTA alignment of mtDNA sequences from the Western Palaearctic Hyles euphorbiae complex (HEC; Lepidoptera: Sphingidae)

description: Alignment (FASTA format) of partial sequences of mitochondrial genes COI/II and interjacent tRNA-leucine from 889 specimens of the Hyles euphorbiae complex (HEC; Lepidoptera: Sphingidae) from various localities covering virtually its entire Western Palaearctic distribution range (Macaronesia, Maghreb, Europe, Middle East, Western Asia).<br><br>From the original sequences (see Genbank accession numbers in Tab. S1 of the associated publication: Mende et al., 2016, Scientific Reports), base positions with &gt;10 ambiguities in the total alignment were deleted from all sequences and the few remaining ambiguities at non-informative sites were overwritten to the respective base at their particular locus and those at parsimony-informative sites to the most common base of the corresponding haplogroup. The present alignment includes the deleted positions within the sequences ("?") for coherence of the sequence and easy inference of base triplets; all calculations of the associated publication were done without "?" positions. <br><br><br>key to file:<br><br>&gt;XXX- (= abbreviation of pooled populations; corresponds to abbreviations in Figs. 1, 3 and 7 and Tab. S1 of the associated publication)<br><br>#### (= voucher number in the invertebrates tissue catalogue of the Museum für Tierkunde Dresden, Germany; corresponds to column "MTD-TW #" in Tab. S1 of the associated publication)<br><br>NNNNN [= sequence of mitochondrial genes COI (from position 1-1463), tRNA-leucine (1464-1525) and COII (position 1526-2127); ? = data that has been deleted from sequences for calculations due to ambiguities (see above)]
DOI: 10.6084/m9.figshare.3438275
title: Gene annotation coordinate files

description: These files contain the coordinates for coding sequences of genes and pseudo-genes that are located on the following clones:a) C. adamanteus clone 29M24b) C. atrox clone 91J7c) C. atrox clone 152I6d) C. scutulatus clone 102I5
DOI: 10.6084/m9.figshare.3438275.v1
title: Gene annotation coordinate files

description: These files contain the coordinates for coding sequences of genes and pseudo-genes that are located on the following clones:a) C. adamanteus clone 29M24b) C. atrox clone 91J7c) C. atrox clone 152I6d) C. scutulatus clone 102I5
DOI: 10.6084/m9.figshare.3438251
title: Datasets for article on burrowing, climbing and upright standing in the laboratory rat

description: Female Sprague-Dawley rats were housed in semi-naturalistic environments. The frequency, duration and temporal distribution of burrowing, climbing, upright standing and lateral stretching were recorded from video when rats were 3, 8 and 13 months old. Frequency of lateral stretching was also recorded in 13 month old rats housed in standard laboratory cages. Videos were scored by 2 scorers, so inter-observer reliability data are also provided.
DOI: 10.6084/m9.figshare.3438191
title: Extracted data.xlsx

description: Data includes demographic characteristics, clinical characteristics and modalities of treatment
DOI: 10.6084/m9.figshare.3438191.v1
title: Extracted data.xlsx

description: Data includes demographic characteristics, clinical characteristics and modalities of treatment
DOI: 10.6084/m9.figshare.3437987
title: CPR data.doc

description: Data of Cardiopulmonary muscular fatigue
DOI: 10.6084/m9.figshare.3437753
title: Supplementary Material for: Serum Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Levels in Older Subjects with Dementia and Mild Cognitive Impairment

description: <b><i>Background:</i></b> The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been involved in both physiological and pathological conditions, including vascular pathologies and pathologies of the central nervous system. Nonetheless, the knowledge about the role of systemic TRAIL in patients affected by different types of dementia and mild cognitive impairment (MCI) is still limited. <b><i>Objective:</i></b> We assessed serum TRAIL levels in a large cohort of older individuals (n = 644) including patients with late-onset Alzheimer's disease (LOAD), vascular dementia (VAD), ‘mixed' dementia (MIX), MCI, and healthy controls. <b><i>Methods:</i></b> Circulating TRAIL was measured by ELISA. <b><i>Results:</i></b> At univariate analysis, TRAIL levels were higher in VAD, MIX, and MCI patients compared with LOAD patients and controls. Using the multiple linear regression model, we found that TRAIL levels were associated with VAD and MCI, but not MIX, independent of potential confounding factors. <b><i>Conclusion:</i></b> The finding of high levels of circulating TRAIL in VAD and MCI seems to suggest that both of these conditions are characterized by a significant vascular damage with respect to LOAD.
DOI: 10.6084/m9.figshare.3437753.v1
title: Supplementary Material for: Serum Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Levels in Older Subjects with Dementia and Mild Cognitive Impairment

description: <b><i>Background:</i></b> The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been involved in both physiological and pathological conditions, including vascular pathologies and pathologies of the central nervous system. Nonetheless, the knowledge about the role of systemic TRAIL in patients affected by different types of dementia and mild cognitive impairment (MCI) is still limited. <b><i>Objective:</i></b> We assessed serum TRAIL levels in a large cohort of older individuals (n = 644) including patients with late-onset Alzheimer's disease (LOAD), vascular dementia (VAD), ‘mixed' dementia (MIX), MCI, and healthy controls. <b><i>Methods:</i></b> Circulating TRAIL was measured by ELISA. <b><i>Results:</i></b> At univariate analysis, TRAIL levels were higher in VAD, MIX, and MCI patients compared with LOAD patients and controls. Using the multiple linear regression model, we found that TRAIL levels were associated with VAD and MCI, but not MIX, independent of potential confounding factors. <b><i>Conclusion:</i></b> The finding of high levels of circulating TRAIL in VAD and MCI seems to suggest that both of these conditions are characterized by a significant vascular damage with respect to LOAD.
DOI: 10.6084/m9.figshare.3437738
title: Supplementary Material for: Genetic Association of TCF4 and AKT1 Gene Variants with the Age at Onset of Schizophrenia

description: <b><i>Background:</i></b> Age at onset (AAO) is a known prognostic indicator for schizophrenia and is hypothesized to correlate with cognition and symptom severity. <i>TCF4 </i>and <i>AKT1</i> are schizophrenia risk genes involved in cognitive functions. The current study examined the interactive effects of <i>TCF4 </i>and <i>AKT1 </i>variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia. <b><i>Methods:</i></b> This study consisted of 322 patients with schizophrenia meeting the DSM-IV criteria. Six single nucleotide polymorphisms (SNPs) of <i>TCF4</i> (rs12966547, rs8766, rs2958182, rs9960767, rs10401120 and rs17512836) and seven <i>AKT1</i> SNPs (rs2498804, rs3803304, rs2494732, rs3730358, rs1130214, rs2498784 and rs3803300) were genotyped using the TaqMan® SNP genotyping-based assays method. The relationship of AAO with each variant was investigated using analyses of covariance. <b><i>Results:</i></b> Among the <i>TCF4</i> variants, rs12966547 (p = 0.024) and rs8766 (p = 0.021) were significantly associated with earlier AAO. We found a lower average AAO in patients with the AA genotype of rs12966547, while the CT genotype of rs8766 was demonstrated to have a protective effect on AAO. For rs8766, there was significant gene × gender interaction (p = 0.012) in influencing AAO. However, these results were not significant after false discovery rate correction. Significant gene × ethnicity interactions were observed to influence AAO (p &lt; 0.05). The Kaplan-Meier curve of the minor AA genotype of rs12966547 displayed a significant trend (p = 0.008) for onset after 19 years of age. Similarly, the minor CC genotype of rs8766 showed a significantly (p = 0.034) lower AAO compared to the TT genotype. <b><i>Conclusion:</i></b> Our analyses suggest that individual risk genotypes may influence the risk of schizophrenia in an age-specific manner.
DOI: 10.6084/m9.figshare.3437738.v1
title: Supplementary Material for: Genetic Association of TCF4 and AKT1 Gene Variants with the Age at Onset of Schizophrenia

description: <b><i>Background:</i></b> Age at onset (AAO) is a known prognostic indicator for schizophrenia and is hypothesized to correlate with cognition and symptom severity. <i>TCF4 </i>and <i>AKT1</i> are schizophrenia risk genes involved in cognitive functions. The current study examined the interactive effects of <i>TCF4 </i>and <i>AKT1 </i>variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia. <b><i>Methods:</i></b> This study consisted of 322 patients with schizophrenia meeting the DSM-IV criteria. Six single nucleotide polymorphisms (SNPs) of <i>TCF4</i> (rs12966547, rs8766, rs2958182, rs9960767, rs10401120 and rs17512836) and seven <i>AKT1</i> SNPs (rs2498804, rs3803304, rs2494732, rs3730358, rs1130214, rs2498784 and rs3803300) were genotyped using the TaqMan® SNP genotyping-based assays method. The relationship of AAO with each variant was investigated using analyses of covariance. <b><i>Results:</i></b> Among the <i>TCF4</i> variants, rs12966547 (p = 0.024) and rs8766 (p = 0.021) were significantly associated with earlier AAO. We found a lower average AAO in patients with the AA genotype of rs12966547, while the CT genotype of rs8766 was demonstrated to have a protective effect on AAO. For rs8766, there was significant gene × gender interaction (p = 0.012) in influencing AAO. However, these results were not significant after false discovery rate correction. Significant gene × ethnicity interactions were observed to influence AAO (p &lt; 0.05). The Kaplan-Meier curve of the minor AA genotype of rs12966547 displayed a significant trend (p = 0.008) for onset after 19 years of age. Similarly, the minor CC genotype of rs8766 showed a significantly (p = 0.034) lower AAO compared to the TT genotype. <b><i>Conclusion:</i></b> Our analyses suggest that individual risk genotypes may influence the risk of schizophrenia in an age-specific manner.
DOI: 10.6084/m9.figshare.3437723
title: Phylogenies of CCapSV, DImmSV and PAegRV

description: Phylogenies of CCapSV, DImmSV and PAegRV were inferred in MrBayes (v3.2.5). A general time reversible model with gamma distributed rate variation and a proportion of invariable sites was used, with parameters estimated from the data during the analysis. A site-specific rate model was used, that allowed each codon position to have its own rate. Models were run for 1 million MCMC generations, with trees being sampled every 1000 generations. The first 25 per cent of the trees were discarded to ensure that the chains had reached stationarity, and a consensus tree was created from the remaining trees. Trees are midpoint rooted.
DOI: 10.6084/m9.figshare.3437723.v1
title: Phylogenies of CCapSV, DImmSV and PAegRV

description: Phylogenies of CCapSV, DImmSV and PAegRV were inferred in MrBayes (v3.2.5). A general time reversible model with gamma distributed rate variation and a proportion of invariable sites was used, with parameters estimated from the data during the analysis. A site-specific rate model was used, that allowed each codon position to have its own rate. Models were run for 1 million MCMC generations, with trees being sampled every 1000 generations. The first 25 per cent of the trees were discarded to ensure that the chains had reached stationarity, and a consensus tree was created from the remaining trees. Trees are midpoint rooted.
DOI: 10.6084/m9.figshare.3437654
title: Carbon monoxide adsorption on anatase TiO2 nanoparticles

description: <br>Graphical abstract of the article:"On the Simple Complexity of Carbon Monoxide on Oxide Surfaces: Facet-Specific Donation and Backdonation Effects Revealed on TiO2 Anatase Nanoparticles"ChemPhysChem. doi:10.1002/cphc.201600284<br>IR and modeling studies on TiO<sub>2</sub> nanoparticles reveal that the stretching frequency of adsorbed CO results from a synergic donation/backdonation mechanism, by which the surface oxygen anions act as electron donors even if not directly bonded to the adsorbate.<br><br>This item also contains an additional figure of the Ti sites and a simplified representation of the Ti-CO bonding mechanism. Both images were created for a blog post. Further material can be found at the links below. The last link refers to the above-mentioned blog post explaining and commenting the findings of the article.<br><br>
DOI: 10.6084/m9.figshare.3437654.v4
title: Carbon monoxide adsorption on anatase TiO2 nanoparticles

description: <br>Graphical abstract of the article:"On the Simple Complexity of Carbon Monoxide on Oxide Surfaces: Facet-Specific Donation and Backdonation Effects Revealed on TiO2 Anatase Nanoparticles"ChemPhysChem. doi:10.1002/cphc.201600284<br>IR and modeling studies on TiO<sub>2</sub> nanoparticles reveal that the stretching frequency of adsorbed CO results from a synergic donation/backdonation mechanism, by which the surface oxygen anions act as electron donors even if not directly bonded to the adsorbate.<br><br>This item also contains an additional figure of the Ti sites and a simplified representation of the Ti-CO bonding mechanism. Both images were created for a blog post. Further material can be found at the links below. The last link refers to the above-mentioned blog post explaining and commenting the findings of the article.<br><br>
DOI: 10.6084/m9.figshare.3437654.v3
title: Carbon monoxide adsorption on anatase TiO2 nanoparticles

description: <br>Graphical abstract of the article:"On the Simple Complexity of Carbon Monoxide on Oxide Surfaces: Facet-Specific Donation and Backdonation Effects Revealed on TiO2 Anatase Nanoparticles"ChemPhysChem. doi:10.1002/cphc.201600284<br>IR and modeling studies on TiO<sub>2</sub> nanoparticles reveal that the stretching frequency of adsorbed CO results from a synergic donation/backdonation mechanism, by which the surface oxygen anions act as electron donors even if not directly bonded to the adsorbate.<br>Further material can be found at the links below. The last link refers to a blog post explaining and commenting the findings of the article.<br><br>