cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5821929
title: Additional file 1: Table S1. of Global avian influenza outbreaks 2010â 2016: a systematic review of their distribution, avian species and virus subtype

description: Avian influenza birds affected per virus subtype, country, epidemiological unit and year. References for Table S1. (ZIP 230Â kb)
DOI: 10.6084/m9.figshare.5821929.v1
title: Additional file 1: Table S1. of Global avian influenza outbreaks 2010â 2016: a systematic review of their distribution, avian species and virus subtype

description: Avian influenza birds affected per virus subtype, country, epidemiological unit and year. References for Table S1. (ZIP 230Â kb)
DOI: 10.6084/m9.figshare.5821902
title: Additional file 4: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: E coli results (xlsx). Raw data and calculations. (XLSX 286Â kb)
DOI: 10.6084/m9.figshare.5821902.v1
title: Additional file 4: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: E coli results (xlsx). Raw data and calculations. (XLSX 286Â kb)
DOI: 10.6084/m9.figshare.5821881
title: Additional file 3: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: A Validation by paraquat QTLs (xlsx). Full list of QTL intervals and their details. B Validation by paraquat QTLs measurements (zip). Initial DAT and csv files. (XLSX 53Â kb)
DOI: 10.6084/m9.figshare.5821881.v1
title: Additional file 3: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: A Validation by paraquat QTLs (xlsx). Full list of QTL intervals and their details. B Validation by paraquat QTLs measurements (zip). Initial DAT and csv files. (XLSX 53Â kb)
DOI: 10.6084/m9.figshare.5821872
title: Additional file 2: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: Testing with multiple materials (xlsx). Raw data and calculations. (XLSX 434Â kb)
DOI: 10.6084/m9.figshare.5821872.v1
title: Additional file 2: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: Testing with multiple materials (xlsx). Raw data and calculations. (XLSX 434Â kb)
DOI: 10.6084/m9.figshare.5821869
title: Additional file 5: of The dynamic intein landscape of eukaryotes

description: Sequences of all proteins. This file contains all nDNA, cpDNA, and vDNA inteins and HH proteins used in analyses in this study. (TXT 152Â kb)
DOI: 10.6084/m9.figshare.5821869.v1
title: Additional file 5: of The dynamic intein landscape of eukaryotes

description: Sequences of all proteins. This file contains all nDNA, cpDNA, and vDNA inteins and HH proteins used in analyses in this study. (TXT 152Â kb)
DOI: 10.6084/m9.figshare.5821854
title: Additional file 1: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: Validation by cell counting (xlsx). Raw data and calculations. (XLSX 549Â kb)
DOI: 10.6084/m9.figshare.5821854.v1
title: Additional file 1: of PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

description: Validation by cell counting (xlsx). Raw data and calculations. (XLSX 549Â kb)
DOI: 10.6084/m9.figshare.5821836
title: Additional file 4: of The dynamic intein landscape of eukaryotes

description: DnaBi alignment. This file contains an alignment of cpDnaBi, bacterial DnaBi, and cpClpPi for Fig. 6c. (FA 57Â kb)
DOI: 10.6084/m9.figshare.5821836.v1
title: Additional file 4: of The dynamic intein landscape of eukaryotes

description: DnaBi alignment. This file contains an alignment of cpDnaBi, bacterial DnaBi, and cpClpPi for Fig. 6c. (FA 57Â kb)
DOI: 10.6084/m9.figshare.5821818
title: Additional file 3: of The dynamic intein landscape of eukaryotes

description: Inteins in vDNA. This is a spreadsheet of eukaryotic inteins in vDNA with accession numbers and extein/intein sequences mined in this study. (XLSX 80Â kb)
DOI: 10.6084/m9.figshare.5821818.v1
title: Additional file 3: of The dynamic intein landscape of eukaryotes

description: Inteins in vDNA. This is a spreadsheet of eukaryotic inteins in vDNA with accession numbers and extein/intein sequences mined in this study. (XLSX 80Â kb)
DOI: 10.6084/m9.figshare.5821800
title: Additional file 2: of The dynamic intein landscape of eukaryotes

description: Inteins in nDNA and cpDNA. This is a spreadsheet of eukaryotic inteins in nDNA and cpDNA with accession numbers and extein/intein sequences mined in this study. (XLSX 177Â kb)
DOI: 10.6084/m9.figshare.5821800.v1
title: Additional file 2: of The dynamic intein landscape of eukaryotes

description: Inteins in nDNA and cpDNA. This is a spreadsheet of eukaryotic inteins in nDNA and cpDNA with accession numbers and extein/intein sequences mined in this study. (XLSX 177Â kb)
DOI: 10.6084/m9.figshare.5821791
title: Additional file 1: of Claudin expression during early postnatal development of the murine cochlea

description: â Claudin expression raw dataâ . This file contains the data points collected and analyzed in the text and figures. (XLSX 86 kb)
DOI: 10.6084/m9.figshare.5821791.v1
title: Additional file 1: of Claudin expression during early postnatal development of the murine cochlea

description: â Claudin expression raw dataâ . This file contains the data points collected and analyzed in the text and figures. (XLSX 86 kb)
DOI: 10.6084/m9.figshare.5821674
title: Supplemental materials - "Do natural disasters affect voting behavior? Evidence from Croatian floods"

description: - Data used for the article "Do natural disasters affect voting behavior? Evidence from Croatian floods"- Included are<br>-Database on voting behavior for 2009 and 2014 presidential election- Database on voting behavior for 2011 and 2015 parliamentary election- R script for both databases- Codebook
DOI: 10.6084/m9.figshare.5821626
title: Dataset for: Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia.

description: An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high altitude exposure, elicits physiological acclimatisation mechanisms alongside metabolic remodelling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n=5, male, age 28-54 yrs) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500m. Measurements taken pre and post expedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (+ 3.6) % increase in respiratory exchange ratio measured during incremental exercise (area under curve, p&gt;0.01, mean ±SD) and a 2.1(+ 0.8) % decrease in fat tissue (p&lt;0.05) post expedition. This was accompanied by an 11.6 (+1.9) % increase (p&gt;0.001) in VO2 max corrected to % lean mass post expedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in-depth characterisation of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth.
DOI: 10.6084/m9.figshare.5821626.v1
title: Dataset for: Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia.

description: An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high altitude exposure, elicits physiological acclimatisation mechanisms alongside metabolic remodelling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n=5, male, age 28-54 yrs) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500m. Measurements taken pre and post expedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (+ 3.6) % increase in respiratory exchange ratio measured during incremental exercise (area under curve, p&gt;0.01, mean ±SD) and a 2.1(+ 0.8) % decrease in fat tissue (p&lt;0.05) post expedition. This was accompanied by an 11.6 (+1.9) % increase (p&gt;0.001) in VO2 max corrected to % lean mass post expedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in-depth characterisation of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth.
DOI: 10.6084/m9.figshare.5821554
title: Identification of reference genes for real-time quantitative polymerase chain reaction based gene expression studies on various Olive (<i>Olea europaea</i> L.) tissues

description: Reference genes are essential for the normalisation of the expression data of quantitative real-time PCR for the purposes of validation. Although several reference genes have been validated for the olive, comprehensive analyses including an excessive number of candidate reference genes still require study in various olive tissue samples. In this work, a total of 40 candidate reference genes were tested for their stability in 8 different olive tissues (root, apical bud, lateral bud, pedicel, young leaf, mature leaf, fruit mesocarp, and seed) with the utilisation of the most popular software programs including GeNorm, NormFinder, BestKeeper, and ΔC<sub>t</sub>. The analyses of expression stability of candidate reference genes using quantitative real-time PCR demonstrated ubiquitin-conjugating enzyme (<i>UBC1</i>) as the most stable reference gene for the studied tissues of the olive. The GeNorm software also calculated the optimum reference gene combinations as two which consist of <i>UBC1</i> and the Clathrin adaptor complex medium subunit (<i>CLATHRIN</i>) genes. This study provides the most stable reference gene combination for normalisation of target genes for quantitative real-time PCR gene expression studies on the olive.
DOI: 10.6084/m9.figshare.5821554.v2
title: Identification of reference genes for real-time quantitative polymerase chain reaction based gene expression studies on various Olive (<i>Olea europaea</i> L.) tissues

description: Reference genes are essential for the normalisation of the expression data of quantitative real-time PCR for the purposes of validation. Although several reference genes have been validated for the olive, comprehensive analyses including an excessive number of candidate reference genes still require study in various olive tissue samples. In this work, a total of 40 candidate reference genes were tested for their stability in 8 different olive tissues (root, apical bud, lateral bud, pedicel, young leaf, mature leaf, fruit mesocarp, and seed) with the utilisation of the most popular software programs including GeNorm, NormFinder, BestKeeper, and ΔC<sub>t</sub>. The analyses of expression stability of candidate reference genes using quantitative real-time PCR demonstrated ubiquitin-conjugating enzyme (<i>UBC1</i>) as the most stable reference gene for the studied tissues of the olive. The GeNorm software also calculated the optimum reference gene combinations as two which consist of <i>UBC1</i> and the Clathrin adaptor complex medium subunit (<i>CLATHRIN</i>) genes. This study provides the most stable reference gene combination for normalisation of target genes for quantitative real-time PCR gene expression studies on the olive.
DOI: 10.21954/ou.rd.5821542
title: Death and Dying Seminar: A debate on assisted suicide (November 2017)

description: Last in the series of Death and Dying seminars held at the Open University on 21st November 2017.<br>This seminar looked at different viewpoints on assisted suicide. After presentations by Lesley Close (Dignity in Dying) and Dr Kevin Yuill (University of Sunderland) attendees engaged in a debate on the topics discussed.<br>Included are the video of the seminar, Why we need an assisted dying law powerpoint presentation and a Seminar review.
DOI: 10.6084/m9.figshare.5821536
title: data_horizontal_leaves.txt from Is countershading camouflage robust to lighting change due to weather?

description: Data file for the bird experiment;data file for the human experiment
DOI: 10.6084/m9.figshare.5821536.v1
title: data_horizontal_leaves.txt from Is countershading camouflage robust to lighting change due to weather?

description: Data file for the bird experiment;data file for the human experiment
DOI: 10.6084/m9.figshare.5821530
title: Dataset for: Interaction of replication protein A with two acidic peptides from human Bloom syndrome protein

description: Bloom syndrome protein (BLM) is one of five human RecQ helicases which maintain genomic stability. Interaction of BLM with replication protein A (RPA) stimulates the DNA unwinding ability of BLM. The interaction is expected to be crucial in DNA damage response systems. Although this stimulation of BLM by RPA is of particular importance in cancer cells, the precise binding surfaces of both proteins are not well understood. In this study, we show by fluorescence polarization anisotropy that both of BLM’s acidic surface peptides specifically bind to RPA70N. Our NMR analysis and docking models show that the basic cleft region of RPA70N is the binding site for both peptides and that the acidic peptide/basic cleft interaction governs RPA-BLM binding.
DOI: 10.6084/m9.figshare.5821530.v1
title: Dataset for: Interaction of replication protein A with two acidic peptides from human Bloom syndrome protein

description: Bloom syndrome protein (BLM) is one of five human RecQ helicases which maintain genomic stability. Interaction of BLM with replication protein A (RPA) stimulates the DNA unwinding ability of BLM. The interaction is expected to be crucial in DNA damage response systems. Although this stimulation of BLM by RPA is of particular importance in cancer cells, the precise binding surfaces of both proteins are not well understood. In this study, we show by fluorescence polarization anisotropy that both of BLM’s acidic surface peptides specifically bind to RPA70N. Our NMR analysis and docking models show that the basic cleft region of RPA70N is the binding site for both peptides and that the acidic peptide/basic cleft interaction governs RPA-BLM binding.
DOI: 10.6084/m9.figshare.5821527
title: The research contributions of predominantly North American Family Medicine educators to medical learner feedback: a descriptive analysis following a scoping review

description: <b>Background and objectives:</b> In 2016, we performed a scoping review as a means of mapping what is known in the literature about feedback to medical learners. In this descriptive analysis, we explore a subset of the results to assess the contributions of predominantly North American family medicine educators to the feedback literature. <b>Methods:</b> Nineteen articles extracted from our original scoping review plus six articles identified from an additional search of the journal Family Medicine are described in-depth. <b>Results:</b> The proportion of articles involving family medicine educators identified in our scoping review is small (n=19/650, 3%) and the total remains low (25) after including additional articles (n=6) from a Family Medicine search. They encompass a broad range of feedback methods and content areas. They primarily originated in the United States (n=19) and Canada (n=3) within Family Medicine Departments (n=20) and encompass a variety of scientific and educational research methodologies. <b>Conclusions:</b> The contributions of predominantly North American Family Medicine educators to the literature on feedback to learners are sparse in number and employ a variety of focus areas and methodological approaches. More studies are needed to assess for areas of education research where family physicians could make valuable contributions.
DOI: 10.6084/m9.figshare.5821527.v1
title: The research contributions of predominantly North American Family Medicine educators to medical learner feedback: a descriptive analysis following a scoping review

description: <b>Background and objectives:</b> In 2016, we performed a scoping review as a means of mapping what is known in the literature about feedback to medical learners. In this descriptive analysis, we explore a subset of the results to assess the contributions of predominantly North American family medicine educators to the feedback literature. <b>Methods:</b> Nineteen articles extracted from our original scoping review plus six articles identified from an additional search of the journal Family Medicine are described in-depth. <b>Results:</b> The proportion of articles involving family medicine educators identified in our scoping review is small (n=19/650, 3%) and the total remains low (25) after including additional articles (n=6) from a Family Medicine search. They encompass a broad range of feedback methods and content areas. They primarily originated in the United States (n=19) and Canada (n=3) within Family Medicine Departments (n=20) and encompass a variety of scientific and educational research methodologies. <b>Conclusions:</b> The contributions of predominantly North American Family Medicine educators to the literature on feedback to learners are sparse in number and employ a variety of focus areas and methodological approaches. More studies are needed to assess for areas of education research where family physicians could make valuable contributions.
DOI: 10.6084/m9.figshare.5821521
title: Supplementary Material for: Microglial Activation Induces Generation of Oligodendrocyte Progenitor Cells from the Subventricular Zone after Focal Demyelination in the Corpus Callosum

description: Neuroblasts derived from neural stem cells (NSCs) in the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb to generate interneurons under normal physiological conditions. When demyelination occurs, NSCs or neural progenitor cells (NPCs) in the SVZ provide newly formed oligodendrocytes to demyelinated lesions. The plasticity of NSC/NPC lineages may tend to oligodendrogenesis under the influence of demyelinated lesions. The mechanisms, however, still remain unknown. This study revealed that focal demyelination in the corpus callosum caused activation of the microglia, not only at the site of demyelination but also in the SVZ, and dramatically increased the generation of oligodendrocyte progenitor cells (OPCs) in the SVZ. Furthermore, the inhibition of microglial activation by minocycline treatment decreased OPC generation in the SVZ, suggesting that microglial activation in the SVZ, induced by the focal demyelination in the corpus callosum, regulates NSC/NPC lineage plasticity in situ. In contrast to the findings regarding demyelination in the corpus callosum, inducing focal demyelination in the internal capsule did not induce either microglial activation or OPC generation in the SVZ. These results suggest that the mechanism of OPC generation in the SVZ after inducing demyelinating lesions could be different across the demyelinated regions.
DOI: 10.6084/m9.figshare.5821521.v1
title: Supplementary Material for: Microglial Activation Induces Generation of Oligodendrocyte Progenitor Cells from the Subventricular Zone after Focal Demyelination in the Corpus Callosum

description: Neuroblasts derived from neural stem cells (NSCs) in the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb to generate interneurons under normal physiological conditions. When demyelination occurs, NSCs or neural progenitor cells (NPCs) in the SVZ provide newly formed oligodendrocytes to demyelinated lesions. The plasticity of NSC/NPC lineages may tend to oligodendrogenesis under the influence of demyelinated lesions. The mechanisms, however, still remain unknown. This study revealed that focal demyelination in the corpus callosum caused activation of the microglia, not only at the site of demyelination but also in the SVZ, and dramatically increased the generation of oligodendrocyte progenitor cells (OPCs) in the SVZ. Furthermore, the inhibition of microglial activation by minocycline treatment decreased OPC generation in the SVZ, suggesting that microglial activation in the SVZ, induced by the focal demyelination in the corpus callosum, regulates NSC/NPC lineage plasticity in situ. In contrast to the findings regarding demyelination in the corpus callosum, inducing focal demyelination in the internal capsule did not induce either microglial activation or OPC generation in the SVZ. These results suggest that the mechanism of OPC generation in the SVZ after inducing demyelinating lesions could be different across the demyelinated regions.
DOI: 10.6084/m9.figshare.5821506
title: Supplementary Material for: Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies

description: <b><i>Aims:</i></b> To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). <b><i>Methods:</i></b> Cross-sectional analyses were performed in pooled data from the CODAM (<i>n</i> = 469) and Hoorn (<i>n</i> = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (µg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. <b><i>Results:</i></b> Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (<i>p</i> values interaction &lt;0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. <b><i>Conclusions:</i></b> This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.
DOI: 10.6084/m9.figshare.5821464
title: data.xlsx

description: We investigate the relationship between social rank and mean cortisol levels, and fluctuations in cortisol levels within individuals across different social ranks.
DOI: 10.6084/m9.figshare.5821464.v2
title: data.xlsx

description: We investigate the relationship between social rank and mean cortisol levels, and fluctuations in cortisol levels within individuals across different social ranks.
DOI: 10.6084/m9.figshare.5821464.v1
title: data.xlsx

description: We investigate the relationship between social rank and mean cortisol levels, and fluctuations in cortisol levels within individuals across different social ranks.
DOI: 10.6084/m9.figshare.5821407
title: RNA-seq data

description: RNA-seq data of ccRCC from TCGA
DOI: 10.6084/m9.figshare.5821401
title: miRNA-seq data

description: miRNA-seq data of ccRCC from TCGA
DOI: 10.6084/m9.figshare.5821401.v1
title: miRNA-seq data

description: miRNA-seq data of ccRCC from TCGA
DOI: 10.6084/m9.figshare.5821398
title: ccRCC-clinical data

description: ccRCC-clinical data from TCGA
DOI: 10.6084/m9.figshare.5821398.v1
title: ccRCC-clinical data

description: ccRCC-clinical data from TCGA
DOI: 10.6084/m9.figshare.5821314
title: Dataset

description: Dataset LTBI agreement TST and QTF in cancer