cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24560839.v1
title: <i>Pycard</i> deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue

description: PYCARD (PYD and CARD domain containing), a pivotal adaptor protein in inflammasome assembly and activation, contributes to innate immunity, and plays an essential role in the pathogenesis of atherosclerosis and restenosis. However, its roles in microRNA biogenesis remain unknown. Therefore, this study aimed to investigate the roles of PYCARD in miRNA biogenesis and neointima formation using <i>pycard</i> knockout (<i>pycard</i><sup>−/−</sup>) mice. Deficiency of <i>Pycard</i> reduced circulating miRNA profile and inhibited <i>Mir17</i> seed family maturation. The systemic <i>pycard</i> knockout also selectively reduced the expression of AGO2 (argonaute RISC catalytic subunit 2), an important enzyme in regulating miRNA biogenesis, by promoting chaperone-mediated autophagy (CMA)-mediated degradation of AGO2, specifically in adipose tissue. Mechanistically, <i>pycard</i> knockout increased PRMT8 (protein arginine N-methyltransferase 8) expression in adipose tissue, which enhanced AGO2 methylation, and subsequently promoted its binding to HSPA8 (heat shock protein family A (Hsp70) member 8) that targeted AGO2 for lysosome degradation through chaperone-mediated autophagy. Finally, the reduction of AGO2 and <i>Mir17</i> family expression prevented vascular injury-induced neointima formation in <i>Pycard</i>-deficient conditions. Overexpression of AGO2 or administration of mimic of <i>Mir106b</i> (a major member of the <i>Mir17</i> family) prevented <i>Pycard</i> deficiency-mediated inhibition of neointima formation in response to vascular injury. These data demonstrate that PYCARD inhibits CMA-mediated degradation of AGO2, which promotes microRNA maturation, thereby playing a critical role in regulating neointima formation in response to vascular injury independently of inflammasome activity and suggest that modulating PYCARD expression and function may represent a powerful therapeutic strategy for neointima formation. <b>Abbreviations:</b> 6-AN: 6-aminonicotinamide; ACTB: actin, beta; aDMA: asymmetric dimethylarginine; AGO2: argonaute RISC catalytic subunit 2; CAL: carotid artery ligation; CALCOCO2: calcium binding and coiled-coil domain 2; CMA: chaperone-mediated autophagy; CTSB: cathepsin B; CTSD: cathepsin D; DGCR8: DGCR8 microprocessor complex subunit; DOCK2: dedicator of cyto-kinesis 2; EpiAdi: epididymal adipose tissue; HSPA8: heat shock protein family A (Hsp70) member 8; IHC: immunohistochemical; ISR: in-stent restenosis; KO: knockout; LAMP2: lysosomal-associated membrane protein 2; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; miRNA: microRNA; NLRP3: NLR family pyrin domain containing 3; N/L: ammonium chloride combined with leupeptin; PRMT: protein arginine methyltransferase; PVAT: peri-vascular adipose tissues; PYCARD: PYD and CARD domain containing; sDMA: symmetric dimethylarginine; ULK1: unc-51 like kinase 1; VSMCs: vascular smooth muscle cells; WT: wild-type.
DOI: 10.48597/r6we-6vne
title: Measurement of Heptachlorepoxide at Turlough Hill

description: Measurement of Heptachlorepoxide at Turlough Hill
DOI: 10.6084/m9.figshare.24179229
title: AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer

description: Most breast cancers do not respond to immune checkpoint inhibitors and there is an urgent need to identify novel sensitization strategies. Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy for this purpose. Our initial observations showed that RB1CC1 depletion leads to accumulation of AZI2, in puncta along with selective macroautophagy/autophagy cargo receptors, which are both required for TBK1 activation. Specifically, disrupting the selective autophagy function of RB1CC1 was sufficient to sustain AZI2 puncta accumulation and TBK1 activation. AZI2 then mediates downstream activation of DDX3X, increasing its interaction with IRF3 for transcription of pro-inflammatory chemokines. Consequently, we performed a screen to identify inhibitors that can induce the AZI2-TBK1 pathway, and this revealed Lys05 as a pharmacological agent that induced pro-inflammatory chemokine expression and CD8<sup>+</sup> T cell infiltration into tumors. Overall, we have identified a distinct AZI2-TBK1-IFN signaling pathway that is responsive to selective autophagy blockade and can be activated to make breast cancers more immunogenic. <b>Abbreviations:</b> AZI2/NAP1: 5-azacytidine induced 2; CALCOCO2: calcium binding and coiled-coil domain 2; DDX3X: DEAD-box helicase 3 X-linked; FCCP: carbonyl cyanide p-triflouromethoxyphenylhydrazone; a protonophore that depolarizes the mitochondrial inner membrane; ICI: immune checkpoint inhibitor; IFN: interferon; NBR1: NBR1 autophagy cargo receptor; OPTN: optineurin; RB1CC1/FIP200: RB1 inducible coiled-coil 1; SQSTM1/p62: sequestosome 1; TAX1BP1: Tax1 binding protein 1; TBK1: TANK binding kinase 1
DOI: 10.6084/m9.figshare.24179229.v2
title: AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer

description: Most breast cancers do not respond to immune checkpoint inhibitors and there is an urgent need to identify novel sensitization strategies. Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy for this purpose. Our initial observations showed that RB1CC1 depletion leads to accumulation of AZI2, in puncta along with selective macroautophagy/autophagy cargo receptors, which are both required for TBK1 activation. Specifically, disrupting the selective autophagy function of RB1CC1 was sufficient to sustain AZI2 puncta accumulation and TBK1 activation. AZI2 then mediates downstream activation of DDX3X, increasing its interaction with IRF3 for transcription of pro-inflammatory chemokines. Consequently, we performed a screen to identify inhibitors that can induce the AZI2-TBK1 pathway, and this revealed Lys05 as a pharmacological agent that induced pro-inflammatory chemokine expression and CD8<sup>+</sup> T cell infiltration into tumors. Overall, we have identified a distinct AZI2-TBK1-IFN signaling pathway that is responsive to selective autophagy blockade and can be activated to make breast cancers more immunogenic. <b>Abbreviations:</b> AZI2/NAP1: 5-azacytidine induced 2; CALCOCO2: calcium binding and coiled-coil domain 2; DDX3X: DEAD-box helicase 3 X-linked; FCCP: carbonyl cyanide p-triflouromethoxyphenylhydrazone; a protonophore that depolarizes the mitochondrial inner membrane; ICI: immune checkpoint inhibitor; IFN: interferon; NBR1: NBR1 autophagy cargo receptor; OPTN: optineurin; RB1CC1/FIP200: RB1 inducible coiled-coil 1; SQSTM1/p62: sequestosome 1; TAX1BP1: Tax1 binding protein 1; TBK1: TANK binding kinase 1
DOI: 10.48597/rrsm-s97x
title: Measurement of Particle_number_size_distribution at DEM_Athens

description: Measurement of Particle_number_size_distribution at DEM_Athens
DOI: 10.6084/m9.figshare.25115336
title: ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells

description: Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression and chemotherapeutic resistance. ANXA2 (annexin A2), a potential therapeutic target for TNBC, has been reported to stimulate autophagy. In this study, we investigated the role of ANXA2 in autophagic processes in TNBC cells. TNBC patients exhibited high levels of ANXA2, which correlated with poor outcomes. ANXA2 increased LC3B-II levels following bafilomycin A<sub>1</sub> treatment and enhanced autophagic flux in TNBC cells. Notably, ANXA2 upregulated the phosphorylation of HSF1 (heat shock transcription factor 1), resulting in the transcriptional activation of <i>ATG7</i> (autophagy related 7). The mechanistic target of rapamycin kinase complex 2 (MTORC2) played an important role in ANXA2-mediated <i>ATG7</i> transcription by HSF1. MTORC2 did not affect the mRNA level of <i>ANXA2</i>, but it was involved in the protein stability of ANXA2. HSPA (heat shock protein family A (Hsp70)) was a potential interacting protein with ANXA2, which may protect ANXA2 from lysosomal proteolysis. ANXA2 knockdown significantly increased sensitivity to doxorubicin, the first-line chemotherapeutic regimen for TNBC treatment, suggesting that the inhibition of autophagy by ANXA2 knockdown may overcome doxorubicin resistance. In a TNBC xenograft mouse model, we demonstrated that ANXA2 knockdown combined with doxorubicin administration significantly inhibited tumor growth compared to doxorubicin treatment alone, offering a promising avenue to enhance the effectiveness of chemotherapy. In summary, our study elucidated the molecular mechanism by which ANXA2 modulates autophagy, suggesting a potential therapeutic approach for TNBC treatment. <b>Abbreviation:</b> ATG: autophagy related; ChIP: chromatin-immunoprecipitation; HBSS: Hanks’ balanced salt solution; HSF1: heat shock transcription factor 1; MTOR: mechanistic target of rapamycin kinase; TNBC: triple-negative breast cancer; TFEB: transcription factor EB; TFE3: transcription factor binding to IGHM enhancer 3
DOI: 10.6084/m9.figshare.25115336.v1
title: ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells

description: Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression and chemotherapeutic resistance. ANXA2 (annexin A2), a potential therapeutic target for TNBC, has been reported to stimulate autophagy. In this study, we investigated the role of ANXA2 in autophagic processes in TNBC cells. TNBC patients exhibited high levels of ANXA2, which correlated with poor outcomes. ANXA2 increased LC3B-II levels following bafilomycin A<sub>1</sub> treatment and enhanced autophagic flux in TNBC cells. Notably, ANXA2 upregulated the phosphorylation of HSF1 (heat shock transcription factor 1), resulting in the transcriptional activation of <i>ATG7</i> (autophagy related 7). The mechanistic target of rapamycin kinase complex 2 (MTORC2) played an important role in ANXA2-mediated <i>ATG7</i> transcription by HSF1. MTORC2 did not affect the mRNA level of <i>ANXA2</i>, but it was involved in the protein stability of ANXA2. HSPA (heat shock protein family A (Hsp70)) was a potential interacting protein with ANXA2, which may protect ANXA2 from lysosomal proteolysis. ANXA2 knockdown significantly increased sensitivity to doxorubicin, the first-line chemotherapeutic regimen for TNBC treatment, suggesting that the inhibition of autophagy by ANXA2 knockdown may overcome doxorubicin resistance. In a TNBC xenograft mouse model, we demonstrated that ANXA2 knockdown combined with doxorubicin administration significantly inhibited tumor growth compared to doxorubicin treatment alone, offering a promising avenue to enhance the effectiveness of chemotherapy. In summary, our study elucidated the molecular mechanism by which ANXA2 modulates autophagy, suggesting a potential therapeutic approach for TNBC treatment. <b>Abbreviation:</b> ATG: autophagy related; ChIP: chromatin-immunoprecipitation; HBSS: Hanks’ balanced salt solution; HSF1: heat shock transcription factor 1; MTOR: mechanistic target of rapamycin kinase; TNBC: triple-negative breast cancer; TFEB: transcription factor EB; TFE3: transcription factor binding to IGHM enhancer 3
DOI: 10.48597/sqjv-g5dx
title: Measurement of Heavy metals at Auchencorth Moss

description: Measurement of Heavy metals at Auchencorth Moss
DOI: 10.48597/tew7-bctc
title: Measurement of Particle_number_size_distribution at DEM_Athens

description: Measurement of Particle_number_size_distribution at DEM_Athens
DOI: 10.48597/ucxw-3wxv
title: Measurement of Nitrogen_monoxide at Chilbolton Observatory

description: Measurement of Nitrogen_monoxide at Chilbolton Observatory
DOI: 10.48597/vafm-2dfa
title: Measurement of Heptachlorepoxide at Turlough Hill

description: Measurement of Heptachlorepoxide at Turlough Hill
DOI: 10.48597/wddd-rya6
title: Measurement of Heptachlorepoxide at Turlough Hill

description: Measurement of Heptachlorepoxide at Turlough Hill
DOI: 10.48597/we33-rjm2
title: Measurement of Nitrogen_monoxide at Chilbolton Observatory

description: Measurement of Nitrogen_monoxide at Chilbolton Observatory
DOI: 10.48597/wqby-5z66
title: Measurement of Nitrogen_dioxide at Barcelona (Palau Reial)

description: Measurement of Nitrogen_dioxide at Barcelona (Palau Reial)
DOI: 10.48597/x38x-83z7
title: Measurement of Inorganics in air and particle phase at Auchencorth Moss

description: Measurement of Inorganics in air and particle phase at Auchencorth Moss
DOI: 10.48597/x3qg-fbkw
title: Measurement of Inorganics in air and particle phase at Auchencorth Moss

description: Measurement of Inorganics in air and particle phase at Auchencorth Moss
DOI: 10.48597/xd6g-9484
title: Measurement of Inorganics in air and particle phase at Auchencorth Moss

description: Measurement of Inorganics in air and particle phase at Auchencorth Moss
DOI: 10.48597/xpxz-6pzq
title: Measurement of Heptachlorepoxide at Turlough Hill

description: Measurement of Heptachlorepoxide at Turlough Hill
DOI: 10.48597/y9v8-8px4
title: Measurement of Inorganics in air and particle phase at Narberth

description: Measurement of Inorganics in air and particle phase at Narberth
DOI: 10.15468/dl.4s022d
title: Occurrence Download

description: A dataset containing 387 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cryptogramma stelleri (S.G.Gmel.) Prantl",
 "Country is United States of America"
 ]
}

 The dataset includes 387 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010578-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.auswuj
title: Occurrence Download

description: A dataset containing 274 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Heleobia australis (d'Orbigny, 1835)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 },
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is MANAGED"
 ]
 }
 },
 {
 "not" : {
 "EstablishmentMeans" : [
 "is not null"
 ]
 }
 }
 ]
 },
 {
 "or" : [
 "OccurrenceStatus is Present",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is not null"
 ]
 }
 }
 ]
 }
 ]
}

 The dataset includes 274 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0054459-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zq6rrt
title: Occurrence Download

description: A dataset containing 1367 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Anopheles albimanus Wiedemann, 1820"
 ]
}

 The dataset includes 1367 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037121-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.alvihh
title: Occurrence Download

description: A dataset containing 790 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Coleophora gryphipennella (Hübner, 1796)"
 ]
}

 The dataset includes 790 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010578-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qs9kgb
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((112.32861 23.95679,112.80322 23.4646,113.34815 23.37671,114.20947 23.16577,116.47705 23.35913,117.8877 24.4292,119.13135 25.80249,120.1333 27.2439,120.44971 29.68726,119.46533 32.23608,117.18018 32.85132,115.36963 32.85132,113.96338 32.71069,112.06494 32.11304,111.01025 28.89624,111.23877 26.61108,111.2915 25.64429,112.32861 23.95679))",
 "TaxonKey is Otis tarda Linnaeus, 1758"
 ]
}

 The dataset includes 7 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034742-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jfutpt
title: Occurrence Download

description: A dataset containing 82 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vipera kaznakovi Nikolsky, 1909"
 ]
}

 The dataset includes 82 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010579-160118175350007/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.psmj35
title: Occurrence Download

description: A dataset containing 3262 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Berberis amurensis Rupr."
 ]
}

 The dataset includes 3262 records from 144 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0054465-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5ctfk6
title: Occurrence Download

description: A dataset containing 208465 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cisticola exilis (Vigors & Horsfield, 1827)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
}

 The dataset includes 208465 records from 74 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001499-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.awcssl
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Microzooplankton abundance and biomass at station NBP97-08-35-5"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010579-160623103540712/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mrarkp
title: Occurrence Download

description: A dataset containing 12360 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is The Coleoptera collection (EC) of the Muséum national d'Histoire naturelle (MNHN - Paris)"
 ]
}

 The dataset includes 12360 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0316463-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7djtpe
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fimbristylis longistipitata Tang & F.T.Wang"
 ]
}

 The dataset includes 12 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000558-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8e3qsv
title: Occurrence Download

description: A dataset containing 82 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lychnophora brunioides Mart."
 ]
}

 The dataset includes 82 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0283275-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nc1xka
title: Occurrence Download

description: A dataset containing 141 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Thailand",
 "Country is Viet Nam",
 "Country is Myanmar",
 "Country is Lao People’s Democratic Republic",
 "Country is Malaysia",
 "Country is Singapore",
 "Country is Indonesia",
 "Country is Brunei Darussalam",
 "Country is Philippines",
 "Country is Timor-Leste",
 "Country is Papua New Guinea"
 ]
 },
 "HasCoordinate is true",
 "TaxonKey is Matoniaceae",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 141 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010579-171124123535762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yjqmb7
title: Occurrence Download

description: A dataset containing 8209 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Pogoniulus subsulphureus (Fraser, 1843)"
 ]
}

 The dataset includes 8209 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0054452-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vm4rbq
title: Occurrence Download

description: A dataset containing 220988 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "GadmGid is CHN.26_1",
 "OccurrenceStatus is Present",
 "Year 1978-2020"
 ]
}

 The dataset includes 220988 records from 335 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0310874-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vtre74
title: Occurrence Download

description: A dataset containing 1227 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Poland",
 "TaxonKey is Impatiens glandulifera Royle"
 ]
}

 The dataset includes 1227 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0414962-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xpukar
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ctenitis lanceolata (Baker) A.R.Sm.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010580-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.