cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25416333.v1
title: Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases

description: The urgent demand for effective countermeasures against metallo-β-lactamases (MBLs) necessitates development of novel metallo-β-lactamase inhibitors (MBLIs). This study is dedicated to identifying critical chemical moieties within previously developed MBLIs, and critical MBLs should serve as the target in MBLI evaluations. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), a systematic literature analysis was conducted, and the NCBI RefSeq genome database was exploited to access the abundance profile and taxonomic distribution of MBLs and their variant types. Through the implementation of two distinct systematic approaches, we elucidated critical chemical moieties of MBLIs, providing pivotal information for rational drug design. We also prioritised MBLs and their variant types, highlighting the imperative need for comprehensive testing to ensure the potency and efficacy of the newly developed MBLIs. This approach contributes valuable information to advance the field of antimicrobial drug discovery.
DOI: 10.6084/m9.figshare.26984593
title: Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway

description: Rho family GTPases regulate cellular processes and promote tumour growth and metastasis; thus, RhoA is a potential target for tumour metastasis inhibition. However, limited progress has been made in the development of RhoA targeting anticancer drugs. Here, we synthesised benzo[<i>b</i>]thiophene-3-carboxylic acid 1,1-dioxide derivatives based on a covalent inhibitor of RhoA (DC-Rhoin), reported in our previous studies. The observed structure-activity relationship (contributed by carboxamide in C-3 and 1-methyl-1<i>H</i>-pyrazol in C-5) enhanced the anti-proliferative activity of the derivatives. Compound b19 significantly inhibited the proliferation, migration, and invasion of MDA-MB-231 cells and promoted their apoptosis. The suppression of myosin light chain phosphorylation and the formation of stress fibres confirmed the inhibitory activity of b19 via the RhoA/ROCK pathway. b19 exhibited a different binding pattern from DC-Rhoin, as observed in molecular docking analysis. This study provides a reference for the development of anticancer agents targeting the RhoA/ROCK pathway.
DOI: 10.6084/m9.figshare.26984593.v1
title: Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway

description: Rho family GTPases regulate cellular processes and promote tumour growth and metastasis; thus, RhoA is a potential target for tumour metastasis inhibition. However, limited progress has been made in the development of RhoA targeting anticancer drugs. Here, we synthesised benzo[<i>b</i>]thiophene-3-carboxylic acid 1,1-dioxide derivatives based on a covalent inhibitor of RhoA (DC-Rhoin), reported in our previous studies. The observed structure-activity relationship (contributed by carboxamide in C-3 and 1-methyl-1<i>H</i>-pyrazol in C-5) enhanced the anti-proliferative activity of the derivatives. Compound b19 significantly inhibited the proliferation, migration, and invasion of MDA-MB-231 cells and promoted their apoptosis. The suppression of myosin light chain phosphorylation and the formation of stress fibres confirmed the inhibitory activity of b19 via the RhoA/ROCK pathway. b19 exhibited a different binding pattern from DC-Rhoin, as observed in molecular docking analysis. This study provides a reference for the development of anticancer agents targeting the RhoA/ROCK pathway.
DOI: 10.6084/m9.figshare.27063282
title: Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways

description: Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise for treating inflammatory diseases. These compounds fall into two clusters with distinct effects: one inhibits neutrophilic superoxide (SO) anion production and elastase release triggered by N-formyl-Met-Leu-Phe (fMLF), with compound <b>6a</b> being most effective (IC<sub>50</sub> values of 1.23 and 1.37 μM, respectively), affecting c-Jun N-terminal kinase (JNK) and Akt phosphorylation. The second cluster suppresses formation of SO anion without affecting elastase levels, surpassed by compound <b>26a</b> (IC<sub>50</sub> of 1.56 μM), which attenuates various mitogen-activated protein kinases (MAPKs) with minimal Akt impact. Notably, none of the tested compounds showed cytotoxicity in human neutrophils, underscoring their potential as therapeutic agents against inflammatory diseases.
DOI: 10.6084/m9.figshare.27063282.v1
title: Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways

description: Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise for treating inflammatory diseases. These compounds fall into two clusters with distinct effects: one inhibits neutrophilic superoxide (SO) anion production and elastase release triggered by N-formyl-Met-Leu-Phe (fMLF), with compound <b>6a</b> being most effective (IC<sub>50</sub> values of 1.23 and 1.37 μM, respectively), affecting c-Jun N-terminal kinase (JNK) and Akt phosphorylation. The second cluster suppresses formation of SO anion without affecting elastase levels, surpassed by compound <b>26a</b> (IC<sub>50</sub> of 1.56 μM), which attenuates various mitogen-activated protein kinases (MAPKs) with minimal Akt impact. Notably, none of the tested compounds showed cytotoxicity in human neutrophils, underscoring their potential as therapeutic agents against inflammatory diseases.
DOI: 10.6084/m9.figshare.25379273
title: Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer

description: A series of novel benzimidazole derivatives were designed and synthesised based on the structures of reported oral available ALK inhibitor and HDAC inhibitor, pracinostat. In enzymatic assays, compound <b>3b</b>, containing a 2-acyliminobenzimidazole moiety and hydroxamic acid side chain, could inhibit both ALK and HDAC6 (IC<sub>50</sub> = 16 nM and 1.03 µM, respectively). Compound <b>3b</b> also inhibited various ALK mutants known to be involved in crizotinib resistance, including mutant L1196M (IC<sub>50</sub>, 4.9 nM). Moreover, <b>3b</b> inhibited the proliferation of several cancer cell lines, including ALK-addicted H2228 cells. To evaluate its potential for treating cancers <i>in vivo</i>, <b>3b</b> was used in a human A549 xenograft model with BALB/c nude mice. At 20 mg/kg, <b>3b</b> inhibited tumour growth by 85% yet had a negligible effect on mean body weight. These results suggest a attracting route for the further research and optimisation of dual ALK/HDAC inhibitors.
DOI: 10.6084/m9.figshare.25379273.v1
title: Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer

description: A series of novel benzimidazole derivatives were designed and synthesised based on the structures of reported oral available ALK inhibitor and HDAC inhibitor, pracinostat. In enzymatic assays, compound <b>3b</b>, containing a 2-acyliminobenzimidazole moiety and hydroxamic acid side chain, could inhibit both ALK and HDAC6 (IC<sub>50</sub> = 16 nM and 1.03 µM, respectively). Compound <b>3b</b> also inhibited various ALK mutants known to be involved in crizotinib resistance, including mutant L1196M (IC<sub>50</sub>, 4.9 nM). Moreover, <b>3b</b> inhibited the proliferation of several cancer cell lines, including ALK-addicted H2228 cells. To evaluate its potential for treating cancers <i>in vivo</i>, <b>3b</b> was used in a human A549 xenograft model with BALB/c nude mice. At 20 mg/kg, <b>3b</b> inhibited tumour growth by 85% yet had a negligible effect on mean body weight. These results suggest a attracting route for the further research and optimisation of dual ALK/HDAC inhibitors.
DOI: 10.6084/m9.figshare.27274671
title: <i>Bacillus</i> lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation

description: <i>Bacillus</i> lipopeptides have been reported to display anti-obesity effects. In the present study, Lipopeptides from <i>Bacillus velezensis</i> FJAT-45028 that consisted of iturin, fengycin and surfactin were reported. The lipopeptides exhibited a strong lipase inhibition activity in a concentration-dependent manner with a half maximal inhibitory concentration of 0.012 mg/mL, and the inhibition mechanism and type were reversible and competitive, respectively. Results of CCK8 assay showed that 3T3-L1 preadipocyte cells were completely viable under treatment of 0.050–0.2 mg/mL lipopeptides for 24 or 48 h. It was found that the lipopeptides could increase lipid droplets in the differentiated 3T3-L1 adipocytes in tested concentration and suppress the expression of peroxisome proliferator-activated receptor gamma (PPARγ). These results indicated the potential anti-obesity mechanism of the tested lipopeptides might be to inhibit lipase activity but not to suppress lipid accumulation in the adipocytes. Moreover, the lipopeptides could elevate glucose utilisation by 14.43%–33.81% in the differentiated 3T3-L1 adipocytes.
DOI: 10.6084/m9.figshare.27274671.v1
title: <i>Bacillus</i> lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation

description: <i>Bacillus</i> lipopeptides have been reported to display anti-obesity effects. In the present study, Lipopeptides from <i>Bacillus velezensis</i> FJAT-45028 that consisted of iturin, fengycin and surfactin were reported. The lipopeptides exhibited a strong lipase inhibition activity in a concentration-dependent manner with a half maximal inhibitory concentration of 0.012 mg/mL, and the inhibition mechanism and type were reversible and competitive, respectively. Results of CCK8 assay showed that 3T3-L1 preadipocyte cells were completely viable under treatment of 0.050–0.2 mg/mL lipopeptides for 24 or 48 h. It was found that the lipopeptides could increase lipid droplets in the differentiated 3T3-L1 adipocytes in tested concentration and suppress the expression of peroxisome proliferator-activated receptor gamma (PPARγ). These results indicated the potential anti-obesity mechanism of the tested lipopeptides might be to inhibit lipase activity but not to suppress lipid accumulation in the adipocytes. Moreover, the lipopeptides could elevate glucose utilisation by 14.43%–33.81% in the differentiated 3T3-L1 adipocytes.
DOI: 10.15468/dl.hcyqsx
title: Occurrence Download

description: A dataset containing 710 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eremurus spectabilis M.Bieb."
 ]
}

 The dataset includes 710 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049102-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.iin62m
title: Occurrence Download

description: A dataset containing 32 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Iris ventricosa Pall."
 ]
}

 The dataset includes 32 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021377-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.j8d68m
title: Occurrence Download

description: A dataset containing 20122 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Patella vulgata Linnaeus, 1758"
 ]
}

 The dataset includes 20122 records from 150 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0206360-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ctkyxq
title: Occurrence Download

description: A dataset containing 6543355 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hirundo rustica Linnaeus, 1758"
 ]
}

 The dataset includes 6543355 records from 1133 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021377-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2uyfwh
title: Occurrence Download

description: A dataset containing 526074 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Xeno-canto - Bird sounds from around the world"
 ]
}

 The dataset includes 526074 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0203389-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nkncjj
title: Occurrence Download

description: A dataset containing 26 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Cupressus goveniana var. abramsiana (C.B.Wolf) Little",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 26 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021378-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hxudu6
title: Occurrence Download

description: A dataset containing 22458 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Nymphoides peltata (S.G.Gmel.) Kuntze",
 "HasCoordinate is true"
 ]
}

 The dataset includes 22458 records from 236 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0208249-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tpself
title: Occurrence Download

description: A dataset containing 1261 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Wigandia urens (Ruiz & Pav.) Kunth"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1261 records from 91 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021378-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6a8dbq
title: Occurrence Download

description: A dataset containing 345 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eucalyptus urophylla S.T.Blake"
 ]
}

 The dataset includes 345 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0152701-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/0bt-k2w-1d4
title: Agrotis puta (Hübner, 1803)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/222-cf2-vsq
title: Noctua comes Hübner

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6ry-jxb-njc
title: Earias clorana (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/p9w-smt-bkl
title: Euxoa (Euxoa) tritici Linnaeus, 1761

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/y48-2jh-fe3
title: Euxoa (Euxoa) tritici Linnaeus, 1761

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mnz-f9g-ek8
title: Agrotis puta (Hübner, 1803)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ylc-r8j-ta7
title: Laspeyria flexula [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7yj-j3v-mzc
title: Agrotis ipsilon (Hufnagel, 1766)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/t4g-adr-es3
title: Lycophotia porphyrea [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vmb-2tp-eck
title: Hypena rostralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/et6-jd3-hcz
title: Agrotis vestigialis Hufnagel, 1766

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/r5v-033-w8c
title: Agrotis vestigialis Hufnagel, 1766

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.7910/dvn/yb5e8l
title: Replication Data for: "Substantive representation: Explaining the adoption of Indigenous rights legislation in Latin America"

description: Online Appendix and Replication Material (Data + Do-File) for the Article “Substantive representation: Explaining the adoption of Indigenous rights legislation in Latin America” When using the data, please cite this article (&lt;a&gt;https://doi.org/10.1017/lar.2025.15&lt;/a&gt;) &lt;br&gt;
&lt;br&gt;
The dataset used for this article is based on the INDILEX database. It contains yearly information about the number of Indigenous articles adopted in each country since 1979. &lt;br&gt;
&lt;br&gt;
Article Abstract: Indigenous peoples belong to the most underprivileged groups worldwide. To address this situation, countries in Latin America and beyond increasingly recognize Indigenous rights constitutionally. However, these constitutional rights are not implemented equally everywhere. This could relate to the corresponding ordinary law – or lack thereof. Here I ask: Under what conditions are Indigenous peoples represented in ordinary legislation? To answer this question, I collected the original INDILEX dataset on the status of Indigenous peoples and their rights in the legislation of sixteen Latin American countries (1979-2018). Building on the political representation literature, I contrast descriptive representation with political allies, social movements, and favourable context factors as determinants of the substantive representation of Indigenous peoples. The analysis shows that leftist presidents and a broad constitutional mandate are key predictors for Indigenous rights legislation. The role of Indigenous civil society and democracy depends on time frame and operationalization choice.
DOI: 10.3535/91k-vzz-msl
title: Nycteola revayana (Scopoli, 1772)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wlx-k33-vw1
title: Agrotis segetum [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7d9-0wr-0en
title: Triodia sylvina (Linnaeus, 1761)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8mg-k1g-nm8
title: Hepialus humuli (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/afa-jyj-5b7
title: Euclidia (Euclidia) glyphica Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/epw-983-yex
title: Rivula sericealis (Scopoli, 1763)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pvl-40c-zwh
title: Agrotis puta (Hübner, 1803)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ckx-kzx-pab
title: Hypenodes humidalis Doubleday, 1850

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/khn-ymz-4pr
title: Macrochilo cribrumalis (Hübner, 1793)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/19b-7zf-r5z
title: Noctua janthe Borkhausen, 1792

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7k5-gwk-xzm
title: Agrotis exclamationis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1ed-x4f-13m
title: Pechipogo strigilata (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ahn-5me-9hk
title: Euclidia (Callistege) mi Clerck, 1759

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2xh-w8g-nl2
title: Agrotis ripae Hübner, 1823

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/neh-p7v-5y8
title: Noctua interjecta Hübner

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/df7-dsy-02q
title: Catocala nupta Linnaeus, 1767

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vwj-teb-2pz
title: Rivula sericealis (Scopoli, 1763)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7ys-j2q-ksy
title: Minucia lunaris [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b2w-hgt-ml7
title: Laspeyria flexula [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6hz-qjf-br7
title: Catocala sponsa Linnaeus, 1767

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/m5q-r60-2aw
title: Hepialus humuli (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/05h-fcg-hlx
title: Axylia putris Linnaeus, 1761

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/45h-sp7-hef
title: Rivula sericealis (Scopoli, 1763)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tjg-vee-a9v
title: Euxoa (Euxoa) nigricans Linnaeus, 1761

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rv6-9ec-m7q
title: Herminia tarsipennalis Treitschke, 1835

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wqn-mxy-f0q
title: Noctua orbona Hufnagel, 1766

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5k9-cmc-7f4
title: Herminia tarsipennalis Treitschke, 1835

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xyb-q1x-8f0
title: Minucia lunaris [Denis & Schiffermüller], 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.