cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24916107
title: NV and T analysis data.xlsx

description: Norovirus (NV) infection causes acute gastroenteritis in children and adults. Upon infection with NV, specific CD8+ T cells, which play an important role in anti-infective immunity, are activated in the host. Owing to the NV’s wide genotypic variability, it is challenging to develop vaccines with cross-protective abilities against infection. To aid effective vaccine development, we examined specific CD8+ T-cell responses toward viral-structural protein (VP) epitopes, which enable binding to host susceptibility receptors. We isolated peripheral blood mononuclear cells from 196 participants to screen and identify predominant core peptides toward NV main and small envelope proteins using ex vivo and in vitro intracellular cytokine staining assays. Human leukocyte antigen (HLA) restriction characteristics were detected using next-generation sequencing. Three conservative immunodominant VP-derived CD8+ T-cell epitopes, VP294–102 (TDAARGAIN), VP2153–161 (RGPSNKSSN), and VP1141–148 (FPHIIVDV), were identified and restrictively presented by HLA-Cw*0102, HLA-Cw*0702, and HLA-A*1101 alleles, separately. Our findings provide useful insights into the development of future vaccines and treatments for NV infection.
DOI: 10.6084/m9.figshare.24916107.v1
title: NV and T analysis data.xlsx

description: Norovirus (NV) infection causes acute gastroenteritis in children and adults. Upon infection with NV, specific CD8+ T cells, which play an important role in anti-infective immunity, are activated in the host. Owing to the NV’s wide genotypic variability, it is challenging to develop vaccines with cross-protective abilities against infection. To aid effective vaccine development, we examined specific CD8+ T-cell responses toward viral-structural protein (VP) epitopes, which enable binding to host susceptibility receptors. We isolated peripheral blood mononuclear cells from 196 participants to screen and identify predominant core peptides toward NV main and small envelope proteins using ex vivo and in vitro intracellular cytokine staining assays. Human leukocyte antigen (HLA) restriction characteristics were detected using next-generation sequencing. Three conservative immunodominant VP-derived CD8+ T-cell epitopes, VP294–102 (TDAARGAIN), VP2153–161 (RGPSNKSSN), and VP1141–148 (FPHIIVDV), were identified and restrictively presented by HLA-Cw*0102, HLA-Cw*0702, and HLA-A*1101 alleles, separately. Our findings provide useful insights into the development of future vaccines and treatments for NV infection.
DOI: 10.5281/zenodo.10440814
title: PROCUREMENT OF WASTE-FREE COMPLEX LIQUID FERTILIZERS AND THEIR METHODS
DOI: 10.5281/zenodo.10440815
title: PROCUREMENT OF WASTE-FREE COMPLEX LIQUID FERTILIZERS AND THEIR METHODS
DOI: 10.5519/qd.bvqzzhrt
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (21 records)
DOI: 10.5281/zenodo.10440827
title: RAQAMLI TA'LIM RESURSLARINING OLIY TA'LIMDA QO'LLANILISHI VA AHAMIYATI.
DOI: 10.5281/zenodo.10440828
title: RAQAMLI TA'LIM RESURSLARINING OLIY TA'LIMDA QO'LLANILISHI VA AHAMIYATI.
DOI: 10.5519/qd.t3oipuoh
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (3 records)
DOI: 10.6084/m9.figshare.24916125
title: Monitoring the degradation of semi-natural grassland associations under different land-use patterns

description: The topicality of our research topic is justified by the significant change in traditional grassland management in the grassland areas of the Pannonian Basin. Due to several factors, the proportion of fallow grassland, and in parallel of over-exploited pastures, is continuously increasing. In the medium term (11 years), the effects of fallowing (Z), annual mowing (M), mowing and grazing (meadow treatment M + G), and permanent overgrazing (OG) as treatments on the population structure of grassland plants were investigated in a semi-natural grassland community in the Solonyec soil. It was found that the lowest degradation rates in the studied grassland biotope were obtained for the treatment presenting the utilisation pattern of mowing the main grassland phytomass followed by sheep grazing of the coltgrass. The highest degradation levels, which threatened the condition of the grassland community, were measured for the treatment presenting overgrazing with sheep at the end of the experimental period.
DOI: 10.6084/m9.figshare.24916125.v1
title: Monitoring the degradation of semi-natural grassland associations under different land-use patterns

description: The topicality of our research topic is justified by the significant change in traditional grassland management in the grassland areas of the Pannonian Basin. Due to several factors, the proportion of fallow grassland, and in parallel of over-exploited pastures, is continuously increasing. In the medium term (11 years), the effects of fallowing (Z), annual mowing (M), mowing and grazing (meadow treatment M + G), and permanent overgrazing (OG) as treatments on the population structure of grassland plants were investigated in a semi-natural grassland community in the Solonyec soil. It was found that the lowest degradation rates in the studied grassland biotope were obtained for the treatment presenting the utilisation pattern of mowing the main grassland phytomass followed by sheep grazing of the coltgrass. The highest degradation levels, which threatened the condition of the grassland community, were measured for the treatment presenting overgrazing with sheep at the end of the experimental period.
DOI: 10.5519/qd.g1hog74d
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (84 records)
DOI: 10.21227/m3hn-d118
title: Bitcoin memory pool transaction dataset

description: We have collected the transactions in the Bitcoin memory pool from about 17:00 on April 19, 2021 to 21:00 on April 23, 2021 by configuring the Bitcoin full node. This is because the price of bitcoin was high during this period, and frequent transactions caused congestion in the memory pool. The time dependence of Bitcoin transactions is not easy to express in the data on the blockchain. Affected by P2P network conditions, some transactions may not be accessed owing to block broadcasting, but we still obtained and analyzed 244,343 transaction data samples in the memory pool. Each data includes transaction hash, transaction handling fee, transaction size, transaction initiation time, blockchain height at the time of transaction initiation, transaction hash list dependent on the exchange, number of ancestor and descendant transactions in the transaction pool, transaction version number, transaction lock time, transaction input information, and transaction output information.
DOI: 10.5517/ccdc.csd.cc2bj265
title: CCDC 2160396: Experimental Crystal Structure Determination

description: Related Article: Rachel E. Nuttall, Truc Thuy Pham, Ailis C. Chadwick, Ingebjrg N. Hungnes, George Firth, Martin A. Heckenast, Hazel A. Sparkes, M. Carmen Galan, Michelle T. Ma, Paul G. Pringle|2023|Inorg.Chem.|62|20582|doi:10.1021/acs.inorgchem.2c04008
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.24915870.v2
title: Traits estimated when grown alone may underestimate competitive advantage and invasiveness of exotic species

description: This repository contains all the compiled data and code from the work "Traits estimated when grown alone may underestimate competitive advantage and invasiveness of exotic species" .
DOI: 10.5519/qd.c2zp5txx
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (8 records)
DOI: 10.21227/r3n1-y317
title: Bitcoin partial transaction autonomous message dataset

description: In the Bitcoin transaction autonomous message data set, we collected the transaction autonomy messages in the first 750,360 blocks of Bitcoin. The first message came from block 228,596. The data set spans from about 22:00 on March 29, 2013, to 8:00 on August 21, 2022. We collected 51,463,687 transaction autonomy messages from the Bitcoin system. For transaction autonomous messages in the data set, we converted hexadecimal characters into ASCII characters. For the convenience of viewing, we marked the character '0x00' as the character '.'. Each data includes message ID, transaction hash, transaction version number, block height, block hash, block timestamp, whether it is Coinbase, the sequence number of transactions in the block, input quantity, output quantity, input amount, output amount, transaction fee, the sequence number of scripts in the transaction output, and so on.
DOI: 10.5519/qd.xm0ho8m0
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (7 records)
DOI: 10.6084/m9.figshare.24276916
title: Haplotype-resolved genome assembly and annotation of Malus hybrid cultivar Flame and Malus hybrid cultivar Royalty

description: Malus cv. ‘Royalty’ and Malus cv. ‘Flame’ are representative ornamental crabapples, rich in flavonoids and serving as the preferred materials for studying the coloration mechanism.
DOI: 10.6084/m9.figshare.24916161
title: Supplementary Material for: Genetics of retinitis pigmentosa and other hereditary retinal disorders in Western Switzerland

description: Abstract
Introduction: Mutational screening of inherited retinal disorders is prerequisite for gene targeted therapy. Our aim is to report and analyze the proportions of mutations in inherited retinal disease (IRD) causing genes from a single center in Switzerland in order to describe the distribution of IRDs in Western Switzerland.
Methods: We conducted a retrospective study of patient records. Criteria for inclusion were residence in Western Switzerland for patients and relatives presenting a clinical diagnosis of IRDs and an established molecular diagnosis managed by the genetics service of the Jules-Gonin Eye Hospital (JGEH) of Lausanne between January 2002 and December 2022. We initially investigated the IRD phenotypes in all patients (full cohort) with a clinical diagnosis, then calculated the distribution of IRD gene mutations in the entire cohort (genetically determined cohort). We analyzed a sub-group that comprised pediatric patients (≤ 18 years of age). In addition, we calculated the distribution of gene mutations within the most represented IRDs. Comprehensive gene screening was performed using a combined approach of different generation of DNA microarray analysis, direct sequencing and Sanger sequencing.
Results: The full cohort comprised 899 individuals from 690 families with a clinical diagnosis of IRDs. We identified 400 individuals from 285 families with an elucidated molecular diagnosis (variants in 84 genes) in the genetically determined cohort. The pediatric cohort included 89 individuals from 65 families with an elucidated molecular diagnosis. The molecular diagnosis rate for the genetically determined cohort was 58.2 % (family ratio) and the 5 most frequently implicated genes per family were ABCA4 (11.6 %), USH2A (7.4 %), EYS (6.7 %), PRPH2 (6.3 %) and BEST1 (4.6 %). The pediatric cohort had a family molecular diagnosis rate of 64.4 % and the 5 most common mutated genes per family were RS1 (9.2 %), ABCA4 (7.7 %), CNGB3 (7.7 %), CACNA1F (6.2 %), CEP290 (4.6 %). 
Conclusions: This study describes the genetic mutation landscape of IRDs in Western Switzerland in order to quantify their disease burden and contribute to a better orientation of the development of future gene targeted therapies.
DOI: 10.6084/m9.figshare.24916167
title: Supplementary Material for: Impact of first wave of COVID-19 pandemic on mortality at emergency department in elderly patients with covid and non-covid diagnoses

description: Introduction: Mortality in emergency departments (ED) is not well known. This study aimed to assess the impact of the first-wave pandemic on deaths accounted in the ED of older patients with COVID and non-covid diseases.
Methods: We used data from the EDEN (Emergency Department and Elderly Needs) cohort (preCOVID period) and from the EDEN-Covid cohort (COVID period) that included all patients ≥65 years seen in 52 Spanish EDs from April 1 to 7, 2019, and March 30 to April 5, 2020, respectively. We recorded patient characteristics and final destination at ED. We compared older patients in the pre-COVID period, with older patients with non-covid and with covid-19. ED-Mortality (before discharge or hospitalization) is the prior outcome and was expressed as an adjusted Odds Ratio (aOR) with 95% interval confidence (IC). 
Results: We included 23,338 older patients from the preCOVID period (aged 78.3 (8.1) years), 6,715 patients with non-covid conditions (aged 78.9 (8.2) years) and 3,055 with covid (aged 78.3 (8.3) years) from the COVID period. Compared to the older patients preCOVID period, patients with non-covid and with COVID-19 were more often male, referred by a doctor and by ambulance, with more comorbidity and disability, dementia, nursing-home and more risk according to qSOFA, respectively (p&lt;0.001). Compared to the preCOVID period, patients with non-covid and with covid-19 were more often to be hospitalized from ED (24.8% vs 44.3% vs 79.1%) and were more often to die in ED (0.6% vs 1.2% vs 2.2%), respectively (p&lt;0.001). Compared to the pre-covid period, aOR for age, sex, comorbidity and disability, ED mortality in elderly patients cared in ED during the COVID period was 2.31 (95% CI 1,76-3,06), and 3.75 (95% CI 2.77-5.07) for patients with COVID. By adding the variable qSOFA to the model, such OR were 1.59 (95% CI 1,11-2.30) and 2.16 (95% CI 1,47-3,17), respectively.
Conclusions: During the early first pandemic wave of COVID-19, more complex and life-threatening older with COVID and non-covid diseases were seen compared to the pre-covid period. In addition, the need for hospitalization and the ED-mortality doubled in non-covid and tripled in COVID diagnosis. This increase in ED mortality is not only explained by the complexity or severity of the elderly patients but also because of the system's overload.
DOI: 10.6084/m9.figshare.24916167.v1
title: Supplementary Material for: Impact of first wave of COVID-19 pandemic on mortality at emergency department in elderly patients with covid and non-covid diagnoses

description: Introduction: Mortality in emergency departments (ED) is not well known. This study aimed to assess the impact of the first-wave pandemic on deaths accounted in the ED of older patients with COVID and non-covid diseases.
Methods: We used data from the EDEN (Emergency Department and Elderly Needs) cohort (preCOVID period) and from the EDEN-Covid cohort (COVID period) that included all patients ≥65 years seen in 52 Spanish EDs from April 1 to 7, 2019, and March 30 to April 5, 2020, respectively. We recorded patient characteristics and final destination at ED. We compared older patients in the pre-COVID period, with older patients with non-covid and with covid-19. ED-Mortality (before discharge or hospitalization) is the prior outcome and was expressed as an adjusted Odds Ratio (aOR) with 95% interval confidence (IC). 
Results: We included 23,338 older patients from the preCOVID period (aged 78.3 (8.1) years), 6,715 patients with non-covid conditions (aged 78.9 (8.2) years) and 3,055 with covid (aged 78.3 (8.3) years) from the COVID period. Compared to the older patients preCOVID period, patients with non-covid and with COVID-19 were more often male, referred by a doctor and by ambulance, with more comorbidity and disability, dementia, nursing-home and more risk according to qSOFA, respectively (p&lt;0.001). Compared to the preCOVID period, patients with non-covid and with covid-19 were more often to be hospitalized from ED (24.8% vs 44.3% vs 79.1%) and were more often to die in ED (0.6% vs 1.2% vs 2.2%), respectively (p&lt;0.001). Compared to the pre-covid period, aOR for age, sex, comorbidity and disability, ED mortality in elderly patients cared in ED during the COVID period was 2.31 (95% CI 1,76-3,06), and 3.75 (95% CI 2.77-5.07) for patients with COVID. By adding the variable qSOFA to the model, such OR were 1.59 (95% CI 1,11-2.30) and 2.16 (95% CI 1,47-3,17), respectively.
Conclusions: During the early first pandemic wave of COVID-19, more complex and life-threatening older with COVID and non-covid diseases were seen compared to the pre-covid period. In addition, the need for hospitalization and the ED-mortality doubled in non-covid and tripled in COVID diagnosis. This increase in ED mortality is not only explained by the complexity or severity of the elderly patients but also because of the system's overload.
DOI: 10.5519/qd.eqs0k10j
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (17 records)
DOI: 10.5519/qd.pnbme8pj
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (10 records)
DOI: 10.6084/m9.figshare.20859589.v1
title: Artificial restoration efforts drive communitysuccession and assembly in a desert during the past 53 years

description: The data and code are from "Artificial restoration efforts drive communitysuccession and assembly in a desert during the past 53 years".
DOI: 10.5519/qd.tw7gcxqm
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (4 records)
DOI: 10.6084/m9.figshare.24916158
title: A Stochastic Analysis of the Linguistic Provenance of English Place Names

description: In English place name analysis, meanings are often derived from the resemblance of roots in place names to topographical features, proper names and/or habitation terms in one of the languages that have had an influence on English place names. The problem here is that it is sometimes difficult to determine the base language to use to interpret the roots. The purpose of this paper is to stochastically determine the resemblance between 18799 English place names and 84687 place names from Ireland, Scotland, Wales, Denmark, Norway, Sweden, France, Germany, the Netherlands and Ancient Rome. Each English place name is ranked according to the extent to which it resembles place names from the other countries, and this provides a basis for determining the likely language to use to interpret the place name. A number of observations can be made using the ranking provided. In particular, it is found that ‘Harlington’ is the most archetypically English place name in the English sample, and ‘Anna’ is the least. Furthermore, it is found that the place names in the non-English datasets are most similar to Norwegian place names and least similar to Welsh place names.
DOI: 10.5281/zenodo.10426551
title: The evolution and future of research on Nature-based Solutions to address societal challenges

description: This dataset comprises the bibliographic text files used to analyse the Nature-based Solutions research landscape as presented in:



Dunlop, T., Khojasteh, D., Cohen-Shacham, E., Glamore, W., Haghani, M., van den Bosch, M., Rizzi, D., Greve, P., Felder, S. The Evolution and Future of Research on Nature-based Solutions to Address Societal Challenges. Communications Earth & Environment. 2024.


Excel spreadsheets containing data for the Global Water Security Index (Gain et al., 2016) presented in Figure 2 and the data required to reproduce Figures 1 and 2 in the paper above are also shared.
DOI: 10.5281/zenodo.10426552
title: The evolution and future of research on Nature-based Solutions to address societal challenges

description: This dataset comprises the bibliographic text files used to analyse the Nature-based Solutions research landscape as presented in:



Dunlop, T., Khojasteh, D., Cohen-Shacham, E., Glamore, W., Haghani, M., van den Bosch, M., Rizzi, D., Greve, P., Felder, S. The Evolution and Future of Research on Nature-based Solutions to Address Societal Challenges. Communications Earth & Environment. 2024.


Excel spreadsheets containing data for the Global Water Security Index (Gain et al., 2016) presented in Figure 2 and the data required to reproduce Figures 1 and 2 in the paper above are also shared.
DOI: 10.6084/m9.figshare.24916251
title: A novel collaborative electric location routing problem with battery-swapping stations considering range anxiety

description: This is the experimental data of the manuscript entitled “A novel collaborative electric location routing problem with battery-swapping stations considering range anxiety”.
DOI: 10.6084/m9.figshare.24916251.v1
title: A novel collaborative electric location routing problem with battery-swapping stations considering range anxiety

description: This is the experimental data of the manuscript entitled “A novel collaborative electric location routing problem with battery-swapping stations considering range anxiety”.
DOI: 10.7270/q2rv0sq0
title: BindingDB Entry 50016150: A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.

description: Small molecule binding data for protein Replicase polyprotein 1ab, Uniprot P0DTD1
DOI: 10.7270/q2wm1jfq
title: BindingDB Entry 50016147: Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

description: Small molecule binding data for protein Orexin receptor type 2 and Orexin/Hypocretin receptor type 1, Uniprot O43613 and O43614
DOI: 10.7270/q21c21v3
title: BindingDB Entry 50016146: Novel difluoromethyl-containing 1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1H-indole scaffold as potent 5-HT

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 6, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, and Cytochrome P450 3A4, Uniprot P05177, P08684, P10635, P11712, P33261, and P50406
DOI: 10.7270/q251437d
title: BindingDB Entry 50016143: 4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors.

description: Small molecule binding data for protein Aromatase, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, and Cytochrome P450 3A4, Uniprot P05177, P08684, P10635, P11511, P11712, and P33261
DOI: 10.7270/q28s4tw4
title: BindingDB Entry 50016142: Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay.

description: Small molecule binding data for protein Heat shock protein HSP 90-alpha, Histone deacetylase 1, Histone deacetylase 3, Histone deacetylase 6, and Histone deacetylase 7, Uniprot O15379, P07900, Q13547, Q8WUI4, and Q9UBN7
DOI: 10.7270/q2dj5kmv
title: BindingDB Entry 50016140: Design, synthesis and antitumor activity study of a gemcitabine prodrug conjugated with a HDAC6 inhibitor.

description: Small molecule binding data for protein Cytochrome P450 1A2, Cytochrome P450 2C6, Cytochrome P450 2D1, Cytochrome P450 2E1, and Cytochrome P450 3A2, Uniprot P04799, P05178, P05182, P05183, and P10633