cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19328675.v1
title: Supplementary Material for: Impact of Glucose Tolerance and Its Change on Incident Proteinuria: Analysis of a Nationwide Population-Based Dataset

description: <b><i>Introduction:</i></b> Although diabetes mellitus (DM) increases the risk of proteinuria, the relationship between prediabetes and proteinuria remains not fully understood. Further, whether the change in glucose is associated with the risk for proteinuria is unknown. <b><i>Methods:</i></b> This was a retrospective cohort study that included 1,849,074 participants (median age, 45 years; 59.3% men). No participants were taking glucose-lowering medications, and none had positive proteinuria at the initial health check-up. Each participant was categorized into three groups: normal (hemoglobin A1c [HbA1c] of &lt;5.7%, <i>n</i> = 1,563,121), prediabetes (HbA1c of 5.7–6.4%, <i>n</i> = 253,490), and DM (HbA1c of ≥6.5%, <i>n</i> = 32,463) groups. We investigated the association between each HbA1c category and incident proteinuria using Cox proportional hazards models. We analyzed the association between the annual change in HbA1c and the risk for proteinuria. <b><i>Results:</i></b> A total of 65,954 participants developed proteinuria during the observation period. Not only DM (hazard ratio [HR]: 2.15, 95% confidence interval [CI]: 2.07–2.24) but also prediabetes (HR: 1.14, 95% CI: 1.12–1.17) was associated with a greater risk for proteinuria. The relative risk reduction for proteinuria that was associated with prediabetes and DM was 12.3% and 53.5%, respectively. An annual increase in HbA1c was associated with a greater risk for proteinuria. This association was more pronounced in participants having prediabetes. <b><i>Conclusion:</i></b> Not only DM but also prediabetes increased the risk for proteinuria. The influence of change in HbA1c on incident proteinuria was pronounced in people with prediabetes. Optimizing glucose would provide more benefit to individuals having prediabetes for proteinuria prevention.
DOI: 10.6084/m9.figshare.7885133.v1
title: gVCF_NA18608

description: 1000 Genomes gVCF mapped to hs37d5 for NA18608. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.22219327.v1
title: A multi-tissue gene expression atlas in water buffalo

description: This dataset contains a one-to-one orthologous gene list between buffalo and cattle, a gene expression profile of 355 samples and 27,680 genes in buffalo, as well as a gene expression profile of 355 samples and 16,497 orthologous genes. Additionally, it includes tissue-specific expression genes, housekeeping genes list in buffalo, and conserved and differentially expressed genes list between buffalo and cattle.
DOI: 10.6084/m9.figshare.28759232.v3
title: test2

description: test21212123
DOI: 10.17632/24dssxsfp9
title: SUPPLEMENTAL INFORMATION Acute graft-versus-host disease presenting as Stevens–Johnson syndrome and toxic epidermal necrolysis: a retrospective cohort study

description: Supplemental material for Manuscript: Acute graft-versus-host disease presenting as Stevens–Johnson syndrome and toxic epidermal necrolysis: a retrospective cohort study (JAAD-D-22-00806R1)

Supplemental Method and Material. Methods and materials for immunohistochemistry.
Supplemental Table I. Immunohistochemical analyses of skin biopsy samples from non-Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)-like acute graft-versus-host disease (aGVHD) patients and SJS/TEN-like aGVHD patients.
Supplemental Table II. Treatment and prognosis for acute graft-versus-host disease with/without Stevens–Johnson syndrome and toxic epidermal necrolysis symptoms.
Supplemental Figure 1. Clinical pictures of a patient with Stevens–Johnson syndrome/toxic epidermal necrolysis-like acute graft-versus-host disease.
Supplemental Figure 2. Histopathology of skin lesions of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)-like acute graft-versus-host disease (aGVHD).
Supplemental Figure 3. Comparison of immunohistochemistry on skin biopsy samples from non-Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)-like acute graft-versus-host disease (aGVHD) patients and SJS/TEN-like aGVHD patients.
Supplemental Figure 4. Kaplan–Meier curves for probability of survival in acute graft-versus-host disease patients.
DOI: 10.6084/m9.figshare.13502547.v1
title: Supplementary Material for: Utilization of Machine Learning-Based Computer Vision and Voice Analysis to Derive Digital Biomarkers of Cognitive Functioning in Trauma Survivors

description: <b><i>Background:</i></b> Alterations in multiple domains of cognition have been observed in individuals who have experienced a traumatic stressor. These domains may provide important insights in identifying underlying neurobiological dysfunction driving an individual’s clinical response to trauma. However, such assessments are burdensome, costly, and time-consuming. To overcome barriers, efforts have emerged to measure multiple domains of cognitive functioning through the application of machine learning (ML) models to passive data sources. <b><i>Methods:</i></b> We utilized automated computer vision and voice analysis methods to extract facial, movement, and speech characteristics from semi-structured clinical interviews in 81 trauma survivors who additionally completed a cognitive assessment battery. A ML-based regression framework was used to identify variance in visual and auditory measures that relate to multiple cognitive domains. <b><i>Results:</i></b> Models derived from visual and auditory measures collectively accounted for a large variance in multiple domains of cognitive functioning, including motor coordination (<i>R</i><sup>2</sup> = 0.52), processing speed (<i>R</i><sup>2</sup> = 0.42), emotional bias (<i>R</i><sup>2</sup> = 0.52), sustained attention (<i>R</i><sup>2</sup> = 0.51), controlled attention (<i>R</i><sup>2</sup> = 0.44), cognitive flexibility (<i>R</i><sup>2</sup> = 0.43), cognitive inhibition (<i>R</i><sup>2</sup> = 0.64), and executive functioning (<i>R</i><sup>2</sup> = 0.63), consistent with the high test-retest reliability of traditional cognitive assessments. Face, voice, speech content, and movement have all significantly contributed to explaining the variance in predicting functioning in all cognitive domains. <b><i>Conclusions:</i></b> The results demonstrate the feasibility of automated measurement of reliable proxies of cognitive functioning through low-burden passive patient evaluations. This makes it easier to monitor cognitive functions and to intervene earlier and at a lower threshold without requiring a time-consuming neurocognitive assessment by, for instance, a licensed psychologist with specialized training in neuropsychology.
DOI: 10.6084/m9.figshare.25827103.v4
title: Raw data,interactive CTI network and MCODE sub-network diagram

description: The raw data used to obtain the network target, The interactive CTI network graph created, and detailed information on the MCODE sub-network diagram。用于获取网络目标的原始数据、创建的交互式 CTI 网络图以及 MCODE 子网图上的详细信息
DOI: 10.6084/m9.figshare.22357987.v1
title: Repeats annotation

description: <em>Gymnothorax reevesii</em> genome has a high content of repetative elements.
DOI: 10.6084/m9.figshare.28024736.v1
title: My Data

description: <b>Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation, and delay neuronal death in a mice model of Retinitis Pigmentosa</b>
DOI: 10.17632/hg8ps7v965
title: Extracellular vesicles supplement miR-143-3p to improve the dermal fibrosis of scleroderma

description: Data for Extracellular vesicles supplement miR-143-3p to improve the dermal fibrosis of scleroderma
DOI: 10.17632/jwjkszg4dx
title: STRM_Datasets

description: This contains the data used to validate the method proposed in "SpatioTemporally Resolved Multivariate Pattern Analysis for M/EEG", by Higgins et al 2021. Dataset contains (i) MEG data recorded during presentation of visual stimuli, and (ii) EEG data recorded during a cognitive value estimation task. For details see https://www.biorxiv.org/content/10.1101/2021.08.17.456594v1
DOI: 10.6084/m9.figshare.1466784.v1
title: Data for "Extinction Events can Accelerate Evolution"

description: This fileset provides csv files containing the results from the PLoS ONE paper "Extinction Events can Accelerate Evolution." abstract_model.csv provides the data for Fig. 1 er_wheeled_evolvability_over_generations.csv provides the data for Fig 3a. er_wheeled_final_evolvability provides the data for Fig 3c. er_biped_evolvability_over_generations.csv provides the data for Fig 3b. er_biped_final_evolvability.csv provides the data for Fig. 3d. er_wheeled_niches_fitness.csv provides the data for Fig. 4a and 5a. er_biped_niches_fitness.csv provides the data for Fig. 4b and 5b.
DOI: 10.17632/5gmsnv8zw9
title: JNK signaling regulates oviposition in the malaria vector Anopheles gambiae

description: This study addressed the role of the stress and immune signaling pathway, c-Jun N-terminal kinase (JNK) in the egg laying behaviour of female Anopheles gambiae mosquitoes that is licensed by mating. The study originated from a microarray analysis of heads of mated or virgin females which identified only a small number (24 genes) of significant expression changes 16 of which were connected to processes linked to wounding and coagulation responses such as melanization which can, in turn be linked to JNK signalling. To explain this gene signature we hypothesised that perhaps mating might increase JNK signalling in the heads of females. Much of the data here are western blots which attempt to document changes in the levels of phospho-JNK in different tissues and following different stimuli. In Figure 1 we document increases in pJNK in the head after mating and use RNAi to deplete JNK pathway components which reduce the number of mated blood fed females who oviposit their eggs. The data shown (Figure 1 d) reflect the number of females in multiple experiments who oviposited eggs by day 4 after mating. In Figure 2 we show that using RNAi to deplete puckered (dsp5) a JNK phosphatase, the levels of pJNK are artificially raised in the heads of virgin females and not strikingly in the reproductive tracts of the same females, and that this is enough to cause oviposition in a fraction of blood-fed virgin females that can be blocked by concomitant depletion of JNK itself, revealing JNK as the dominant target of puckered in driving this phenotype. Again the western blot data document changes in pJNK levels in head or reproductive tract after dspuc injection and the numbers of females ovipositing after differing dsRNA treatments and multiple experiments. In Figure 3 we mimic mating by injecting a steroid hormone 20 hydroxyecdysone (20E), normally transferred to females from the male during mating and previously shown to be sufficient to induce oviposition in blood fed virgin females, and find that this too increases pJNK levels selectively in the head - we saw no consistent effect in the reproductive tract - as well as oviposition in blood fed virgins that is inhibited by JNK pathway depletion. Again data show western blots for pJNK after 20E or control (solvent) injection and number of females ovipositing after differing RNAi treatments. Supplementary data support the main conclusions of the paper by: (S1) showing tissue and pathway selectivity of pJNK activation in the head after mating; (S2) comparing relative transcript levels of the two JNK genes known in Anopheles JNK1 and JNK3; (S3) effective depletion of JNK pathway components by RNAi including after double injections of dsJNK1 and dspuc; (S4) showing dsJNK1 reduces pJNK levels after mating; (S5) showing no significant effect of JNK pathway depletion on the process of egg development and; (S6) showing the mating-induced up regulation of wounding-related genes could be inhibited by dsJNK.
DOI: 10.17632/8tfr8xfrgb
title: Supplementary Documents on Thai-British Negotiations after WWII

description: As my research on Thailand’s post-war negotiations with Britain relies on archival records from the UK, US, and Thailand, it is essential to provide appendices of relevant documents for future researchers interested in the subject. Thus, readers of my research would find it beneficial to read my paper alongside these appendices. The UK and US documents, being in English, present no issues. However, Thai cabinet minutes, recorded in Thai, cannot be photocopied. Instead, I took notes and selected passages relevant to my research. To preserve the originality of these Thai documents, I have decided not to translate them into English. Researchers may use translation tools to cross-check their meanings. When referencing this dataset, please cite Charoenvattananukul, Peera “Supplementary Documents on Thai-British Negotiations after WWII”, Mendeley Data, V1, DOI: 10.17632/8tfr8xfrgb.1
DOI: 10.6084/m9.figshare.7883594.v1
title: gVCF_HG01134

description: 1000 Genomes gVCF mapped to hs37d5 for HG01134. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.25679760.v1
title: P101SC18011322-01-B1-16_result.tar.gz

description: RNA-seq analysis of differented GFP and shPPA1 3T3-L1 cells at 0,2,6 day post MDI induction
DOI: 10.6084/m9.figshare.25927240.v1
title: H7_W

description: Power related data for House 7
DOI: 10.6084/m9.figshare.23544708.v1
title: Supplementary Material for: Molecular and Functional Heterogeneity of Primary Pancreatic Neuroendocrine Tumors and Metastases

description: <b><i>Introduction:</i></b> Treatment response to the standard therapy is low for metastatic pancreatic neuroendocrine tumors (PanNETs) mainly due to the tumor heterogeneity. We investigated the heterogeneity between primary PanNETs and metastases to improve the precise treatment. <b><i>Methods:</i></b> The genomic and transcriptomic data of PanNETs were retrieved from the Genomics, Evidence, Neoplasia, Information, Exchange (GENIE), and Gene Expression Omnibus (GEO) database, respectively. Potential prognostic effects of gene mutations enriched in metastases were investigated. Gene set enrichment analysis was performed to investigate the functional difference. Oncology Knowledge Base was interrogated for identifying the targetable gene alterations. <b><i>Results:</i></b> Twenty-one genes had significantly higher mutation rates in metastases which included TP53 (10.3% vs. 16.9%, <i>p</i> = 0.035) and KRAS (3.7% vs. 9.1%, <i>p</i> = 0.016). Signaling pathways related to cell proliferation and metabolism were enriched in metastases, whereas epithelial-mesenchymal transition (EMT) and TGF-β signaling were enriched in primaries. Gene mutations were highly enriched in metastases that had significant unfavorable prognostic effects included mutation of TP53 (<i>p</i> &lt; 0.001), KRAS (<i>p</i> = 0.001), ATM (<i>p</i> = 0.032), KMT2D (<i>p</i> = 0.001), RB1 (<i>p</i> &lt; 0.001), and FAT1 (<i>p</i> &lt; 0.001). Targetable alterations enriched in metastases included mutation of TSC2 (15.5%), ARID1A (9.7%), KRAS (9.1%), PTEN (8.7%), ATM (6.4%), amplification of EGFR (6.0%), MET (5.5%), CDK4 (5.5%), MDM2 (5.0%), and deletion of SMARCB1 (5.0%). <b><i>Conclusion:</i></b> Metastases exhibited a certain extent of genomic and transcriptomic diversity from primary PanNETs. TP53 and KRAS mutation in primary samples might associate with metastasis and contribute to a poorer prognosis. A high fraction of novel targetable alterations enriched in metastases deserves to be validated in advanced PanNETs.
DOI: 10.6084/m9.figshare.17170994.v1
title: A genome-wide association study of total child psychiatric problems scores: summary statistics

description: Summary statistics for EAGLE GWAS on total child psychiatric problems scores. <br> Data is provided in R binary format and can be loaded within R with load("total_child_psychiatric_GWAS.Rdata"). <br> snp: SNP RS ID effect_allele: Effect allele other_allele: Other allele beta: Change in total psychiatric problem score in SD per number of effect allele se: Standard Error p: p-value n: Sample Size <br> For more information, see PLOS ONE publication: <br> Neumann A, Nolte IM, [...], Hartman C & Tiemeier H. A genome-wide association study of total child psychiatric problems scores. PloS one. 2022 Aug 22;17(8):e0273116. https://doi.org/10.1371/journal.pone.0273116 <br> Abstract: Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The SNP heritability of total psychiatric problems was 5.4% (SE=0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of <em>SBF2</em>, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total psychiatric problem score were shared with known genetic variants for common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (r<sub>G</sub> &gt; 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (r<sub>G</sub> &lt; 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation of with intelligence, educational attainment, wellbeing, smoking, and body fat (r<sub>G</sub> &gt; 0.29).The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between psychiatric disorders and related traits. <br> <br> <br>
DOI: 10.6084/m9.figshare.23246087.v1
title: Unshaded Electron Microscopy Images

description: Unshaded electron microscopy images for the manuscript: The exit of nanoparticles from solid tumours.https://www.nature.com/articles/s41563-023-01630-0
DOI: 10.6084/m9.figshare.1111543.v8
title: Come funziona la cognizione. Proposte per le leggi della cognizione e per gli strumenti che consentono di esprimerle

description: I think that the main reason why we do not understand the general principles of how knowledge works (and probably also the reason why we have not yet designed and built efficient machines capable of artificial intelligence), is not the excessive complexity of cognitive phenomena, but the lack of the conceptual and methodological tools to properly address the problem. It is like trying to build up Physics without the concept of number, or to understand the origin of species without including the mechanism of natural selection. In this paper I propose some new conceptual and methodological tools, which seem to offer a real opportunity to understand the logic of cognitive processes. I propose a new method to properly treat the concepts of structure and schema, and to perform on them operations of structural analysis. These operations allow to move straightforwardly from concrete to more abstract representations. With these tools I will suggest a definition for the concept of rule, of regularity and of emergent phenomena. From the analysis of some important aspects of the rules, I suggest to distinguish them in operational and associative rules. I propose that associative rules assume a dominant role in cognition. I also propose a definition for the concept of problem. At the end I will briefly illustrate a possible general model for cognitive systems.
DOI: 10.6084/m9.figshare.17372345.v1
title: Supplementary Material for: Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages

description: Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli. Previously, we reported that thrombin-derived C-terminal peptides (TCPs) are internalized in monocytes and macrophages in a time- and temperature-dependent manner. In this study, we investigated which endocytosis pathways are responsible for the internalization of TCPs. Using confocal microscopy and flow cytometry, we show that both clathrin-dependent and clathrin-independent pathways are involved in the internalization of the prototypic TCP GKY25 in RAW264.7 and human monocyte-derived M1 macrophages, whereas the uptake of GKY25 in monocytic THP-1 cells is mainly dynamin-dependent. Internalized GKY25 was transported to endosomes and finally lysosomes, where it remained detectable for up to 10 h. Comparison of GKY25 uptake with that of the natural occurring TCPs HVF18 and FYT21 indicates that the pathway of TCP endocytosis is not only cell type-dependent but also depends on the length and composition of the peptide as well as the presence of LPS and bacteria. Finally, using neutron reflectometry, we show that the observed differences between HVF18 and the other 2 TCPs may be explained partially by differences in membrane insertion. Taken together, we show that TCPs are differentially internalized into monocytes and macrophages.
DOI: 10.6084/m9.figshare.27224397.v1
title: Supplementary Material for: Urgent-Start Peritoneal Dialysis in Metformin-Associated Lactic Acidosis: A Critical Alternative When Immediate Hemodialysis is Unavailable

description: Introduction
Intermittent hemodialysis (IHD) is a preferable renal replacement therapy (RRT) option in metformin-associated lactic acidosis (MALA) due to rapid correct metabolic acidosis. However, IHD might not be started immediately. Immediate urgent-start peritoneal dialysis (iUSPD) is used as a life-saving dialysis option and then followed by IHD. The outcomes of iUSPD were compared with other extracorporeal dialysis in MALA.
Methods
In two tertiary hospitals in Thailand, the outcomes of patients with MALA who had received three different RRT modalities (iUSPD followed by IHD, IHD, and continuous renal replacement therapy [CRRT]) from January 2015 to December 2019 were compared. The primary outcome was 30-day mortality. The secondary outcomes were door-to-dialysis time and 90-day RRT dependence.
Results 
180 MALA cases that required dialysis were included (20 iUSPD, 120 IHD, and 40 CRRT). Their mean age was 64 years. Most of the patients had severe metabolic acidosis (mean pH 6.91, HCO3 6 mmol/L, and anion gap 40 mmol/L) and were critically ill. The 30-day mortality was 30% in iUSPD, 9.2% in IHD, and 32.5% in CRRT, p = 0.001). The mortality risk in the iUSPD group was not significantly different from those of the IHD and CRRT groups (adjusted HR 2.5, 95% CI 0.65–9.6 and adjusted HR 0.75, 95% CI 0.2–2.78, respectively). All dialysis modalities had comparable 90-day dialysis dependence. iUSPD exhibited the shortest door-to-dialysis time. 
Conclusion
In MALA, iUSPD followed by IHD might be a viable RRT option to save patient lives if no other dialysis option are available.
DOI: 10.17632/ws6b9bgnvj
title: bibliometrics analysis data of work engagement (1974-2021)

description: The original bibliographic data for this table was obtained from the Scopus database on 13 October 2021. There are two tables for the original data to provide data support for the bibliometric analysis of work engagement.
DOI: 10.6084/m9.figshare.13053398.v1
title: SoMo.ml Layer 3

description: SoMo.ml global soil moisture data for Layer 3 (30-50 cm).
DOI: 10.6084/m9.figshare.1534517.v1
title: Forensic Accounting and Fraud: Capability and Competence Requirements in Malaysia

description: <strong>Subject Area:</strong> Social Sciences Business & Management Business & Economics <strong>Article Type:</strong> Research Paper <strong>JEL Code:</strong> M4
DOI: 10.6084/m9.figshare.22249480.v1
title: World Climate Analysis

description: This dataset contains the average temperature for each country and city starting from 1830