cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24321049
title: Supplementary Material for: Exploring shared genetic signatures of Alzheimer’s disease and multiple sclerosis: a bioinformatic analysis study

description: Background: Many clinical studies reported the coexistence of Alzheimer’s disease (AD) and multiple sclerosis (MS), but the common molecular signature between AD and MS remains elusive. The purpose of our study is to explore the genetic linkage between AD and MS through bioinformatic analysis, providing new insights into the shared signatures and possible pathogenesis of two diseases. Methods: The common differential expressed genes (DEGs) were determined between AD and MS from datasets obtained from Gene Expression Omnibus (GEO) database. Further, functional and pathway enrichment analysis, PPI network construction, and identification of hub genes were carried out. The expression level of hub genes was validated in two other external AD and MS datasets. Transcription factor (TF)-gene interactions and gene-miRNA interactions were performed in NetworkAnalyst. Finally, receiver operating characteristic (ROC) curve analysis was applied to evaluate the predictive value of hub genes. Results: A total of 75 common DEGs were identified between AD and MS. Functional and pathway enrichment analysis emphasized the importance of exocytosis and synaptic vesicle cycle, respectively. Six significant hub genes, including CCL2, CD44, GFAP, NEFM, STXBP1, and TCEAL6 were identified and verified as common hub genes shared by AD and MS. FOXC1 and hsa-mir-16-5p are the most common TF and miRNA in regulating hub genes, respectively. In the ROC curve analysis, all hub genes showed good efficiency in helping distinguishing patients from controls. Conclusions: Our study firstly identified a common genetic signature between AD and MS, paving the road for investigating shared machanism of AD and MS.
DOI: 10.6084/m9.figshare.24321049.v1
title: Supplementary Material for: Exploring shared genetic signatures of Alzheimer’s disease and multiple sclerosis: a bioinformatic analysis study

description: Background: Many clinical studies reported the coexistence of Alzheimer’s disease (AD) and multiple sclerosis (MS), but the common molecular signature between AD and MS remains elusive. The purpose of our study is to explore the genetic linkage between AD and MS through bioinformatic analysis, providing new insights into the shared signatures and possible pathogenesis of two diseases. Methods: The common differential expressed genes (DEGs) were determined between AD and MS from datasets obtained from Gene Expression Omnibus (GEO) database. Further, functional and pathway enrichment analysis, PPI network construction, and identification of hub genes were carried out. The expression level of hub genes was validated in two other external AD and MS datasets. Transcription factor (TF)-gene interactions and gene-miRNA interactions were performed in NetworkAnalyst. Finally, receiver operating characteristic (ROC) curve analysis was applied to evaluate the predictive value of hub genes. Results: A total of 75 common DEGs were identified between AD and MS. Functional and pathway enrichment analysis emphasized the importance of exocytosis and synaptic vesicle cycle, respectively. Six significant hub genes, including CCL2, CD44, GFAP, NEFM, STXBP1, and TCEAL6 were identified and verified as common hub genes shared by AD and MS. FOXC1 and hsa-mir-16-5p are the most common TF and miRNA in regulating hub genes, respectively. In the ROC curve analysis, all hub genes showed good efficiency in helping distinguishing patients from controls. Conclusions: Our study firstly identified a common genetic signature between AD and MS, paving the road for investigating shared machanism of AD and MS.
DOI: 10.5281/zenodo.10125287
title: Bioenergy cropping systems shape ant community composition and functional roles

description: R code and partial data for Haan, Helms, & Landis 2023, Bioenergy cropping systems shape ant community composition and functional roles, to be published in Frontiers in Conservation Science. The ant species list we use to generate the species matrix was uploaded previously (10.5281/zenodo.8215581) in association with another manuscript (Haan et al. 2023, Science Advances, Contrasting effects of bioenergy crops on biodiversity). Therefore here we include a small table with trait information for each species along with the R code used specifically for this manuscript.
DOI: 10.5281/zenodo.10125286
title: Bioenergy cropping systems shape ant community composition and functional roles

description: R code and partial data for Haan, Helms, & Landis 2023, Bioenergy cropping systems shape ant community composition and functional roles, to be published in Frontiers in Conservation Science. The ant species list we use to generate the species matrix was uploaded previously (10.5281/zenodo.8215581) in association with another manuscript (Haan et al. 2023, Science Advances, Contrasting effects of bioenergy crops on biodiversity). Therefore here we include a small table with trait information for each species along with the R code used specifically for this manuscript.
DOI: 10.6084/m9.figshare.24441085
title: Supplementary Material for: Gut microbe-metabolite profiles are associated with microbial pathways of longevity in women: a cross-sectional study conducted in China

description: Introduction: Recent research on the gut deepens people’s understanding of the role of gut microbe-metabolites in longevity. However, most of the longevity population is female, and the gut microbe-metabolites associated with longevity in women remain unknown. Here, we hypothesize that the gut microbe-metabolite levels differed between the longevity women (LW, age ≥ 90) and the elderly women (EW, 60 &lt; age &lt; 90). Methods: We performed a cross-sectional study of 22 women in Guangxi longevity areas. 16S rRNA full-length sequencing, bioinformatic analysis, and nuclear magnetic resonance hydrogen spectra (1H-NMR) were determined to analyze the gut microbiota, microbial pathways, and fecal metabolites. We evaluated significant differences and relationships in gut microbe-metabolites and microbial pathways using the Mann-Whitney test and Spearman correlation, respectively. Results: The EW experienced gut dysbiosis characterized by a higher Firmicutes/Bacteroidetes (F/B) value. The LW showed a higher abundance of Bacteroides and Alistipes, which might support health maintenance. Moreover, LW enriched alanine, aspartate, and glutamate metabolism, histidine metabolism, and pyruvate metabolism, leading to major changes in histidine, fumaric acid, acetate, valine, and aspartate. Interestingly, the most valuable metabolic pathway based on differential fecal metabolites confirmed the KEGG microbial pathway ‘alanine, aspartate, and glutamate metabolism’ enriched in LW. Impressively, Bacteroides and Alistipes were positively correlated with alanine, aspartate and glutamate metabolism, thus improving the level of aspartate, which could be a particular pathway related to longevity. Conclusion: The enriched gut genus and microbial pathways in LW showed a significant correlation, which might mediate the production of metabolites related to longevity.
DOI: 10.6084/m9.figshare.24441085.v1
title: Supplementary Material for: Gut microbe-metabolite profiles are associated with microbial pathways of longevity in women: a cross-sectional study conducted in China

description: Introduction: Recent research on the gut deepens people’s understanding of the role of gut microbe-metabolites in longevity. However, most of the longevity population is female, and the gut microbe-metabolites associated with longevity in women remain unknown. Here, we hypothesize that the gut microbe-metabolite levels differed between the longevity women (LW, age ≥ 90) and the elderly women (EW, 60 &lt; age &lt; 90). Methods: We performed a cross-sectional study of 22 women in Guangxi longevity areas. 16S rRNA full-length sequencing, bioinformatic analysis, and nuclear magnetic resonance hydrogen spectra (1H-NMR) were determined to analyze the gut microbiota, microbial pathways, and fecal metabolites. We evaluated significant differences and relationships in gut microbe-metabolites and microbial pathways using the Mann-Whitney test and Spearman correlation, respectively. Results: The EW experienced gut dysbiosis characterized by a higher Firmicutes/Bacteroidetes (F/B) value. The LW showed a higher abundance of Bacteroides and Alistipes, which might support health maintenance. Moreover, LW enriched alanine, aspartate, and glutamate metabolism, histidine metabolism, and pyruvate metabolism, leading to major changes in histidine, fumaric acid, acetate, valine, and aspartate. Interestingly, the most valuable metabolic pathway based on differential fecal metabolites confirmed the KEGG microbial pathway ‘alanine, aspartate, and glutamate metabolism’ enriched in LW. Impressively, Bacteroides and Alistipes were positively correlated with alanine, aspartate and glutamate metabolism, thus improving the level of aspartate, which could be a particular pathway related to longevity. Conclusion: The enriched gut genus and microbial pathways in LW showed a significant correlation, which might mediate the production of metabolites related to longevity.
DOI: 10.34740/kaggle/dsv/6967287
title: electricity consumption
DOI: 10.18112/openneuro.ds004661.v1.0.1
title: ANDI
DOI: 10.6084/m9.figshare.24248983
title: Supplementary Material for: Neratinib as extended adjuvant treatment of HER2-positive/HR-positive early breast cancer patients in Germany, Austria and Switzerland: interim results of the prospective, observational ELEANOR study

description: Introduction: Prognosis of patients diagnosed with HER2+ early breast cancer (eBC) has substantially improved, but distant recurrences impacting quality of life and survival still occur. One treatment option for extended adjuvant treatment in patients with HER2+/HR+ eBC is neratinib; available in Europe for patients who completed adjuvant trastuzumab-based therapy within 1 year. The ELEANOR study is investigating the real-world use of neratinib in Germany, Austria and Switzerland. Results from an interim analysis of the first 200 patients observed for ≥3 months are reported. Methods: The primary objective of this prospective, multicentre, observational study is to assess patient adherence to neratinib (defined as percentage of patients taking neratinib on ≥75% prescribed days). Secondary objectives are patient characteristics and treatment outcomes. Results: At cut-off (May 2, 2022), 202 patients had been observed for ≥3 months, with neratinib treatment documented for 187 patients (median age 53.0 years; 67.9% at increased risk of disease recurrence). In total 151 (80.7%) patients had received prior neoadjuvant treatment; of these 82 (54.3%) achieved a pathological complete response. Neratinib was initiated at a median 3.6 months after trastuzumab-based treatment, with 36.4% starting at a dose &lt;240 mg/day. Treatment is ongoing for 46.0% of patients, with median treatment duration of 11.2 (interquartile range 0.9–12.0) months. Diarrhoea was the most common adverse event (78.6% any grade, 20.3% Grade ≥3); pharmacologic prophylaxis was used in 85.6% of patients. Conclusions: The pattern of anti-HER2 pretreatment observed reflected the current treatment for HER2+/HR+ eBC in Germany, Austria and Switzerland. These interim results suggest that neratinib as an extended adjuvant is a feasible option after various anti-HER2 pretreatments, and that its tolerability can be managed and improved with proactive diarrhoea management. ClinicalTrials.gov identifier: NCT04388384
DOI: 10.5281/zenodo.10077205
title: The dataset of duplex ultrasound assessment of the internal mammary artery in women with unilateral mastectomy followed by radiotherapy for breast cancer
DOI: 10.5281/zenodo.10115356
title: The dataset of duplex ultrasound assessment of the internal mammary artery in women with unilateral mastectomy followed by radiotherapy for breast cancer
DOI: 10.6084/m9.figshare.24476551
title: <b>QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures from the promoter of the S100P gene</b>

description: <b>QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures from the promoter of the S100P gene</b>
DOI: 10.18112/openneuro.ds004657.v1.0.2
title: Driving with Autonomous Aids
DOI: 10.5281/zenodo.10125335
title: Underlying dataset Bertolini and Pastres Understanding the influence of swarming timing on the dispersal of Ostrea edulis larvae in the Northern Adriatic Sea

description: Output from opendrift simulations (final larval positions)
DOI: 10.5281/zenodo.10125336
title: Underlying dataset Bertolini and Pastres Understanding the influence of swarming timing on the dispersal of Ostrea edulis larvae in the Northern Adriatic Sea

description: Output from opendrift simulations (final larval positions)
DOI: 10.25380/iastate.24187698
title: Researcher Data Sharing: Behavior and Attitudes, 2018-2021

description: This collection contains data obtained through two rounds of an online survey of faculty and research staff at Iowa State University conducted in May 2018 and September 2021 by the Center for Survey Statistics and Methodology (CSSM) at Iowa State University. All faculty and research staff with job titles or characteristics that suggested they might have research responsibilities employed at the time of each survey were invited to complete the survey through an email invitation and several follow up messages.
DOI: 10.25380/iastate.24187698.v1
title: Researcher Data Sharing: Behavior and Attitudes, 2018-2021

description: This collection contains data obtained through two rounds of an online survey of faculty and research staff at Iowa State University conducted in May 2018 and September 2021 by the Center for Survey Statistics and Methodology (CSSM) at Iowa State University. All faculty and research staff with job titles or characteristics that suggested they might have research responsibilities employed at the time of each survey were invited to complete the survey through an email invitation and several follow up messages.
DOI: 10.18112/openneuro.ds004657.v1.0.3
title: Driving with Autonomous Aids
DOI: 10.6084/m9.figshare.24516988
title: Supplementary Material for: Electronic Patient-Reported Outcomes in Hidradenitis Suppurativa: Content Validity and Usability of the Electronic Hidradenitis Suppurativa Symptom Daily Diary, Hidradenitis Suppurativa Symptom Questionnaire and Hidradenitis Suppurativa Quality of Life Questionnaire

description: Background: Hidradenitis suppurativa (HS), a chronic skin condition that causes pain and physical dysfunction, can impact significantly on quality of life. Disease‑specific tools have been designed to assess the patient impact of HS, including the HS Symptom Daily Diary (HSSDD), the HS Symptom Questionnaire (HSSQ) and the HS Quality of Life (HiSQOL©) questionnaire, which have been developed into electronic instruments (eHSSDD, eHSSQ and eHiSQOL©). Objectives: To establish the content validity of the electronic version of the HSSDD and HSSQ, and the acceptability and usability of the HSSDD, HSSQ and HiSQOL© using concept elicitation and cognitive debriefing interviews. Methods: This was a non‑interventional qualitative video interview study involving participants aged ≥18 years with moderate to severe HS recruited from a single clinical site in the USA. Interviews gathered feedback on participants’ symptom experience, followed by training and completion of the eHSSDD, eHSSQ, and eHiSQOL© questionnaires on electronic hand-held devices. Participants were then interviewed on the content of the eHSSDD and eHSSQ, and the acceptability and usability of all three instruments. Interviews were transcribed and qualitatively analysed. Results: Twenty participants with moderate to severe HS (median age: 41.5 [range: 20.0–64.0]; n=16/20 female) were included. All participants found the eHSSDD, eHSSQ and eHiSQOL© instructions clear, and described the instruments as ‘easy’, ’simple’ and ’self-explanatory’. Overall understanding of individual items within the eHSSDD and eHSSQ was high; however, 6/20 participants had difficulty in understanding the ‘average skin pain’ item in the eHSSDD. All participants were able to accurately recall their symptoms within the recall periods of the eHSSDD and eHSSQ, although 4/20 participants found the 24-hour recall period of the eHSSDD limiting. Completion time was quick across all instruments and usability was high, with the majority of participants reporting no difficulty in completing questionnaires on electronic devices. Conclusion: The concepts covered in the eHSSDD and eHSSQ are relevant and important to patients, supporting their content validity. The findings also provide evidence of acceptability and usability of the eHSSDD, eHSSQ, and eHiSQOL©. A limitation was that all participants were recruited from a single site, which may have introduced selection bias and thus limit the generalisability of results.
DOI: 10.18112/openneuro.ds004660.v1.0.2
title: TNO
DOI: 10.5281/zenodo.10118838
title: Preguntas frecuentes en el campo de las ciencias de datos.

description: El dataset extraído se corresponde con las preguntas con mayor votación obtenida por la comunidad de Stackoverflow pertenecientes al ámbito de la ciencia de datos.
Para conseguir estas preguntas se realiza una filtración de la página con la etiqueta 'data-science' ordenando de mayor a menor, con lo que obtenemos más de 9000 preguntas formuladas.
El conjunto de datos resultante cuenta con 12 columnas y 2500 filas, estas columnas son identificadores de ciertos elementos que encontramos en preguntas realizadas en la página web de Stackoverflow.
Se ha decidido poner un máximo de filas ya que el tiempo invertido en extraer más de las 9000 preguntas puede resultar demasiado elevado y las preguntas más interesantes se encuentran en las primeras filas gracias a la ordenación por las votaciones de los usuarios.
DOI: 10.5281/zenodo.10118839
title: Preguntas frecuentes en el campo de las ciencias de datos.

description: El dataset extraído se corresponde con las preguntas con mayor votación obtenida por la comunidad de Stackoverflow pertenecientes al ámbito de la ciencia de datos.
Para conseguir estas preguntas se realiza una filtración de la página con la etiqueta 'data-science' ordenando de mayor a menor, con lo que obtenemos más de 9000 preguntas formuladas.
El conjunto de datos resultante cuenta con 12 columnas y 2500 filas, estas columnas son identificadores de ciertos elementos que encontramos en preguntas realizadas en la página web de Stackoverflow.
Se ha decidido poner un máximo de filas ya que el tiempo invertido en extraer más de las 9000 preguntas puede resultar demasiado elevado y las preguntas más interesantes se encuentran en las primeras filas gracias a la ordenación por las votaciones de los usuarios.
DOI: 10.5281/zenodo.10119054
title: Broadband waveforms for teleseismic receiver functions in the northwestern part of South America

description: This dataset provides a comprehensive collection of teleseismic events occurring within an epicentral distance range spanning 30° to 130°, featuring a minimum magnitude threshold of Mw > 4.5. Data from 98 triaxial broadband seismological stations affiliated with three distinct seismological networks: the Colombian Geological Survey (RSNC), IRIS-PASSCAL Consortium/USGS, and Volcanological Observatories are incorporated in this dataset. These recordings span the period from 1999 to 2021. The raw waveforms are updated, these were trimmed several seconds before and after the P-wave arrival.
The dataset is systematically arranged in chronological order based on teleseismic events and is presented in the SAC format. Geospatial information pertaining to each event is encapsulated within the header file.
DOI: 10.5281/zenodo.10119055
title: Broadband waveforms for teleseismic receiver functions in the northwestern part of South America

description: This dataset provides a comprehensive collection of teleseismic events occurring within an epicentral distance range spanning 30° to 130°, featuring a minimum magnitude threshold of Mw > 4.5. Data from 98 triaxial broadband seismological stations affiliated with three distinct seismological networks: the Colombian Geological Survey (RSNC), IRIS-PASSCAL Consortium/USGS, and Volcanological Observatories are incorporated in this dataset. These recordings span the period from 1999 to 2021. The raw waveforms are updated, these were trimmed several seconds before and after the P-wave arrival.
The dataset is systematically arranged in chronological order based on teleseismic events and is presented in the SAC format. Geospatial information pertaining to each event is encapsulated within the header file.
DOI: 10.7284/155194
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise MGL2302 using a Hawaii UHDAS instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155192
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL2302 using a CCTech C-Nav 2000 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155195
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL2302 using a CCTech C-Nav 3050 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155191
title: Gyrocompass data collected during research cruise MGL2302 using a Kongsberg Simrad GC80 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155193
title: INS (Inertial Navigation System) data collected during research cruise MGL2302 using a Applanix POS/MV-320 V3 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155199
title: INS (Inertial Navigation System) data collected during research cruise MGL2302 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155196
title: Speedlog data collected during research cruise MGL2302 using a Furuno DS-80 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155198
title: SSV (Sound Speed Velocimeter) data collected during research cruise MGL2302 using a AML MicroSV instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155197
title: TSG (Thermosalinograph) data collected during research cruise MGL2302 using a SeaBird SBE-45 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155206
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise MGL2303 using a Hawaii UHDAS instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155203
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL2303 using a CCTech C-Nav 2000 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/155207
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL2303 using a CCTech C-Nav 3050 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition