cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20676997
title: Development and Chemical Characterization of Pequi Pericarp Flour (Caryocar brasiliense Camb.) and Effect of in vitro Digestibility on the Bioaccessibility of Phenolic Compounds

description: The pequi pericarp corresponds to the largest portion of the fruit and has a high nutritional value, but it is discarded as an agro-industrial residue. The present study aimed to prepare and characterize flours from the pequi pericarp in terms of their proximate composition, its antioxidant potential before and after the in vitro digestibility process and chemical profile, aiming at the full use of this fruit. The samples of pequi pericarp flours from the cities of Sete Lagoas, Paraopeba and Felixlândia were analyzed. The profile of chemical compounds present in the flours was determined using paper spray mass spectrometry. The in vitro simulated digestion technique was used to verify the stability of the phenolic compounds and the maintenance of the antioxidant capacity of the samples. The flours from the pequi pericarp showed to have higher levels of protein, ash and dietary fiber, compared to the data described in the literature for the pulp of the fruit. The analysis of paper spray mass spectrometry allowed the identification of 46 chemical compounds including amino acids, sugars, organic acids and phenolic compounds. The analysis of the main components showed that there was no chemical variation among the fruits from the cities studied. Through the in vitro digestibility technique, it was possible to observe an increase in the bioaccessibility of phenolic compounds, contributing to increase the already significant antioxidant capacity of the samples. It was concluded that the pequi pericarp flour has the potential to be used as a food ingredient due to the high bioaccessibility of its bioactive compounds, capable of reducing the risk of developing diseases caused by oxidative stress.
DOI: 10.6084/m9.figshare.20676997.v1
title: Development and Chemical Characterization of Pequi Pericarp Flour (Caryocar brasiliense Camb.) and Effect of in vitro Digestibility on the Bioaccessibility of Phenolic Compounds

description: The pequi pericarp corresponds to the largest portion of the fruit and has a high nutritional value, but it is discarded as an agro-industrial residue. The present study aimed to prepare and characterize flours from the pequi pericarp in terms of their proximate composition, its antioxidant potential before and after the in vitro digestibility process and chemical profile, aiming at the full use of this fruit. The samples of pequi pericarp flours from the cities of Sete Lagoas, Paraopeba and Felixlândia were analyzed. The profile of chemical compounds present in the flours was determined using paper spray mass spectrometry. The in vitro simulated digestion technique was used to verify the stability of the phenolic compounds and the maintenance of the antioxidant capacity of the samples. The flours from the pequi pericarp showed to have higher levels of protein, ash and dietary fiber, compared to the data described in the literature for the pulp of the fruit. The analysis of paper spray mass spectrometry allowed the identification of 46 chemical compounds including amino acids, sugars, organic acids and phenolic compounds. The analysis of the main components showed that there was no chemical variation among the fruits from the cities studied. Through the in vitro digestibility technique, it was possible to observe an increase in the bioaccessibility of phenolic compounds, contributing to increase the already significant antioxidant capacity of the samples. It was concluded that the pequi pericarp flour has the potential to be used as a food ingredient due to the high bioaccessibility of its bioactive compounds, capable of reducing the risk of developing diseases caused by oxidative stress.
DOI: 10.6084/m9.figshare.20677000.v1
title: The dynamics of financialized capitalism and the Brazilian health system: reflections in the shadows of the COVID-19 pandemic

description: The COVID-19 pandemic in Brazil has highlighted the importance of the Brazilian Unified National Health System (SUS) and the limitations of the country’s prevailing health system, consisting of the public and private sectors, in the context of financialized capitalism in which typical instabilities and crises are structurally determined. The article discusses the Brazilian health system under the aegis of financialized capitalism and during the COVID-19 pandemic. The article contends that financialization as a systemic pattern of wealth increases the process of commodification of socioeconomic relations which is inherent to this system, making the State’s provision of health services indispensable.
DOI: 10.6084/m9.figshare.20677000
title: The dynamics of financialized capitalism and the Brazilian health system: reflections in the shadows of the COVID-19 pandemic

description: The COVID-19 pandemic in Brazil has highlighted the importance of the Brazilian Unified National Health System (SUS) and the limitations of the country’s prevailing health system, consisting of the public and private sectors, in the context of financialized capitalism in which typical instabilities and crises are structurally determined. The article discusses the Brazilian health system under the aegis of financialized capitalism and during the COVID-19 pandemic. The article contends that financialization as a systemic pattern of wealth increases the process of commodification of socioeconomic relations which is inherent to this system, making the State’s provision of health services indispensable.
DOI: 10.6084/m9.figshare.20677003
title: Health plans and insurance: financialization of companies and economic groups that control the private healthcare scheme in Brazil

description: The article aims to describe the characteristics of financialization in a set of ten companies and economic groups operating health plans and insurance in Brazil from 2008 to 2016, selected according to their turnover and the size of their client portfolio. The financial/accounting and net worth dimensions were analyzed according to the balance sheets and cash flows, compared to microeconomic indicators of financialization and the records of changes in the shareholding structure filed with commercial boards. The authors analyzed the companies’ policy positions based on primary data from semi-structured interviews with qualified representatives and the analysis of shareholder reports and news from the specialized media. In short, financial dominance is expressed in the health plans studied here, but their characterization does not follow a universally reproducible and homogeneous pattern, and empirical research should play a key role in further investigating the phenomenon. Since health and healthcare are defined constitutionally as publicly relevant goods that require support by stable and equitable policies in the distribution of available resources, and given the oligopolistic and concentrating trend in the inherent resources in the process of financialization (in opposition to this guideline) and the strategic place occupied by these companies, the prospects for the system as a whole tend to evolve towards an increase in total health expenditures, with greater concentration of healthcare resources and circulation of resources in the financial accumulation sphere.
DOI: 10.6084/m9.figshare.20677003.v1
title: Health plans and insurance: financialization of companies and economic groups that control the private healthcare scheme in Brazil

description: The article aims to describe the characteristics of financialization in a set of ten companies and economic groups operating health plans and insurance in Brazil from 2008 to 2016, selected according to their turnover and the size of their client portfolio. The financial/accounting and net worth dimensions were analyzed according to the balance sheets and cash flows, compared to microeconomic indicators of financialization and the records of changes in the shareholding structure filed with commercial boards. The authors analyzed the companies’ policy positions based on primary data from semi-structured interviews with qualified representatives and the analysis of shareholder reports and news from the specialized media. In short, financial dominance is expressed in the health plans studied here, but their characterization does not follow a universally reproducible and homogeneous pattern, and empirical research should play a key role in further investigating the phenomenon. Since health and healthcare are defined constitutionally as publicly relevant goods that require support by stable and equitable policies in the distribution of available resources, and given the oligopolistic and concentrating trend in the inherent resources in the process of financialization (in opposition to this guideline) and the strategic place occupied by these companies, the prospects for the system as a whole tend to evolve towards an increase in total health expenditures, with greater concentration of healthcare resources and circulation of resources in the financial accumulation sphere.
DOI: 10.6084/m9.figshare.20676942.v1
title: UntitBioactive phytoconstituents and hemostatic and angiogenetic activities of Chromolaena odorata L. leaf extract gel on animal epistaxis model led Item

description: Underlying data of submission of the article entittled: Bioactive phytoconstituents and hemostatic and angiogenetic activities of <em>Chromolaena odorata</em> L. leaf extract gel on animal epistaxis model
DOI: 10.6084/m9.figshare.20677007
title: NEW MULTI-OBJECTIVE VRP INSTANCES MODELLING MAIL DELIVERIES FOR RIO CLARO CITY, SÃO PAULO, BRAZIL

description: ABSTRACT Optimization benchmarks are tools for the validation and comparison of algorithms. Routing benchmarks are particularly relevant to industry. However, there are few available VRP benchmarks based on realistic situations. This research creates a set of multi-objective (three objectives) instances for a length- constrained variant of VRP. The instances model a realistic case of mail delivery performed by mail carriers on foot in the Brazilian city of Rio Claro. A new graph of the city road map was created, and mail carriers’ activities were estimated. Streets were assigned with distinct probability densities to receive deliveries. This research produces 80 mail delivery instances with up to 50,000 deliveries per instance. Finally, bounds for a set of instances were produced. The instances are publicly available for the community to test, compare and validate multi-objective optimization algorithms.
DOI: 10.6084/m9.figshare.20677007.v1
title: NEW MULTI-OBJECTIVE VRP INSTANCES MODELLING MAIL DELIVERIES FOR RIO CLARO CITY, SÃO PAULO, BRAZIL

description: ABSTRACT Optimization benchmarks are tools for the validation and comparison of algorithms. Routing benchmarks are particularly relevant to industry. However, there are few available VRP benchmarks based on realistic situations. This research creates a set of multi-objective (three objectives) instances for a length- constrained variant of VRP. The instances model a realistic case of mail delivery performed by mail carriers on foot in the Brazilian city of Rio Claro. A new graph of the city road map was created, and mail carriers’ activities were estimated. Streets were assigned with distinct probability densities to receive deliveries. This research produces 80 mail delivery instances with up to 50,000 deliveries per instance. Finally, bounds for a set of instances were produced. The instances are publicly available for the community to test, compare and validate multi-objective optimization algorithms.
DOI: 10.6084/m9.figshare.20677010
title: Phosphoric acid containing proanthocyanidin enhances bond stability of resin/dentin interface

description: Abstract Proanthocyanidin (PA) is a promising dentin biomodifier due to its ability to stabilize collagen fibrils against degradation by matrix metalloproteinases (MMPs); however, the most effective protocol to incorporate PA into bonding procedures is still unclear. This study evaluated the effect of dentin biomodification with a PA acid etchant on MMP activity, adhesive interface morphology and resin-dentin microtensile bond strength. Sound extracted human molars were flattened to expose dentin and acid-etched for 15 s according to the groups: EXP - experimental phosphoric acid; EXP+PA - experimental phosphoric acid 10% PA; TE - total-etching system; SE - self-etching system. Samples were restored with composite resin and stored in distilled water (37ºC). MMP activity and interface morphology were analyzed after 24 h by in situ zymography (n=6) and scanning electron microscopy (n=3), respectively. The resin-dentin microtensile bond strength (μTBS) was evaluated after 24 h and 6 months storage (n=6). Significantly higher MMP activity was detected in etched dentin compared with untreated dentin (p&lt;0.05), but no difference among acid groups was found. Resin tags and microtags, indicative of proper adhesive system penetration in dentinal tubules and microtubules, were observed along the hybrid layer in all groups. There was no difference in μTBS between 24 h and 6 months for EXP+PA; moreover, it showed higher long-term μTBS compared with TE and EXP (p&lt;0.05). The results suggest that 15 s of biomodification was not sufficient to significantly reduce MMP activity; nonetheless, EXP+PA was still able to improve resin-dentin bond stability compared with total- and self-etching commercial systems.
DOI: 10.6084/m9.figshare.20677010.v1
title: Phosphoric acid containing proanthocyanidin enhances bond stability of resin/dentin interface

description: Abstract Proanthocyanidin (PA) is a promising dentin biomodifier due to its ability to stabilize collagen fibrils against degradation by matrix metalloproteinases (MMPs); however, the most effective protocol to incorporate PA into bonding procedures is still unclear. This study evaluated the effect of dentin biomodification with a PA acid etchant on MMP activity, adhesive interface morphology and resin-dentin microtensile bond strength. Sound extracted human molars were flattened to expose dentin and acid-etched for 15 s according to the groups: EXP - experimental phosphoric acid; EXP+PA - experimental phosphoric acid 10% PA; TE - total-etching system; SE - self-etching system. Samples were restored with composite resin and stored in distilled water (37ºC). MMP activity and interface morphology were analyzed after 24 h by in situ zymography (n=6) and scanning electron microscopy (n=3), respectively. The resin-dentin microtensile bond strength (μTBS) was evaluated after 24 h and 6 months storage (n=6). Significantly higher MMP activity was detected in etched dentin compared with untreated dentin (p&lt;0.05), but no difference among acid groups was found. Resin tags and microtags, indicative of proper adhesive system penetration in dentinal tubules and microtubules, were observed along the hybrid layer in all groups. There was no difference in μTBS between 24 h and 6 months for EXP+PA; moreover, it showed higher long-term μTBS compared with TE and EXP (p&lt;0.05). The results suggest that 15 s of biomodification was not sufficient to significantly reduce MMP activity; nonetheless, EXP+PA was still able to improve resin-dentin bond stability compared with total- and self-etching commercial systems.
DOI: 10.6084/m9.figshare.20677012
title: Belin/Ambrósio Enhanced Ectasia Display in cataract surgery and relation to final visual acuity

description: ABSTRACT Objective To analyze and describe the coefficients found on maximum Ambrósio Relational Thickness-Maximum (ART-Max) and Belin/Ambrósio Enhanced Ectasia Display total deviation (BAD-D) in eyes with normal corneal topography subjected to cataract surgery with premium intraocular lens implantation and correlated these data with final visual acuity. Methods ART-Max and BAD-D data from 103 eyes of patients subjected to implantation of diffractive bifocal intraocular lens, with normal corneal topography who achieved visual acuity of 20/20 or 20/25 without correction after cataract surgery were analyzed. The groups with normal and abnormal values were compared using the chi-square test. Results Thirty-two (31.1%) and 71 (68.9%) eyes presented normal and abnormal ART-Max values, respectively. The difference between these groups was significant (p=0.0002). Fifty-five (53.4%) and 48 (46.6%) eyes had normal and abnormal BAD-D, respectively, and intergroup difference was not significant (p=0.9576). Conclusion Among patients with normal corneal topography who underwent premium intraocular and had good final visual acuity of 20/20 or 20/25, suspicious or abnormal indices of ART-Max and BAD-D were frequent, providing evidence that it possibly should not be a contraindication.
DOI: 10.6084/m9.figshare.20677012.v1
title: Belin/Ambrósio Enhanced Ectasia Display in cataract surgery and relation to final visual acuity

description: ABSTRACT Objective To analyze and describe the coefficients found on maximum Ambrósio Relational Thickness-Maximum (ART-Max) and Belin/Ambrósio Enhanced Ectasia Display total deviation (BAD-D) in eyes with normal corneal topography subjected to cataract surgery with premium intraocular lens implantation and correlated these data with final visual acuity. Methods ART-Max and BAD-D data from 103 eyes of patients subjected to implantation of diffractive bifocal intraocular lens, with normal corneal topography who achieved visual acuity of 20/20 or 20/25 without correction after cataract surgery were analyzed. The groups with normal and abnormal values were compared using the chi-square test. Results Thirty-two (31.1%) and 71 (68.9%) eyes presented normal and abnormal ART-Max values, respectively. The difference between these groups was significant (p=0.0002). Fifty-five (53.4%) and 48 (46.6%) eyes had normal and abnormal BAD-D, respectively, and intergroup difference was not significant (p=0.9576). Conclusion Among patients with normal corneal topography who underwent premium intraocular and had good final visual acuity of 20/20 or 20/25, suspicious or abnormal indices of ART-Max and BAD-D were frequent, providing evidence that it possibly should not be a contraindication.
DOI: 10.6084/m9.figshare.20676942.v3
title: Bioactive phytoconstituents and hemostatic and angiogenetic activities of Chromolaena odorata L. leaf extract gel on animal epistaxis model

description: Underlying data of submission of the article entittled: Bioactive phytoconstituents and hemostatic and angiogenetic activities of <em>Chromolaena odorata</em> L. leaf extract gel on animal epistaxis model
DOI: 10.6084/m9.figshare.20676942.v2
title: Bioactive phytoconstituents and hemostatic and angiogenetic activities of Chromolaena odorata L. leaf extract gel on animal epistaxis model led Item

description: Underlying data of submission of the article entittled: Bioactive phytoconstituents and hemostatic and angiogenetic activities of <em>Chromolaena odorata</em> L. leaf extract gel on animal epistaxis model
DOI: 10.6084/m9.figshare.20677015
title: Analysis of financial statements from companies in the Brazilian health sector (2009-2015): concentration, centralization of capital, and expressions of financialization

description: The Brazilian health system is characterized by major participation by the private sector. In the current decade, companies working in health-related sectors have stood out in the corporate world due to the results and size of their financial operations. The study analyzed the companies’ trajectory from the perspective of financialization, defined as the dissemination of a pattern of accumulation, characteristic of contemporary capitalism. The article aimed to to analyze the expressions of financialization in the accounting-financial dimension of companies and corporate groups in the Brazilian health sector. The study describes the trajectory of accounting items and indicators from 2009 to 2015, based on an examination of financial statements from 43 companies in 5 subsectors (health plans, hospitals, retail pharmacies, pharmaceutical industry, and diagnostic and therapeutic support services). The results are analyzed in four categories: size, performance, indebtedness, and relevance of financial operations. The results were compared to the overall results for large and open-capital corporations in Brazil. The study reveals central aspects of financialization such as the sector’s growth, the expansion of leading companies, and capital centralization, corroborating hypotheses concerning the concentration and centralization of capital. Other hypotheses, such as the relevant impacts of financial operations on revenues, were not confirmed. Finally, the evidence provided by a strictly accounting-based analysis suggest the need to incorporate other dimensions, especially such strategies as mergers, acquisitions, and other equity operations.
DOI: 10.6084/m9.figshare.20677015.v1
title: Analysis of financial statements from companies in the Brazilian health sector (2009-2015): concentration, centralization of capital, and expressions of financialization

description: The Brazilian health system is characterized by major participation by the private sector. In the current decade, companies working in health-related sectors have stood out in the corporate world due to the results and size of their financial operations. The study analyzed the companies’ trajectory from the perspective of financialization, defined as the dissemination of a pattern of accumulation, characteristic of contemporary capitalism. The article aimed to to analyze the expressions of financialization in the accounting-financial dimension of companies and corporate groups in the Brazilian health sector. The study describes the trajectory of accounting items and indicators from 2009 to 2015, based on an examination of financial statements from 43 companies in 5 subsectors (health plans, hospitals, retail pharmacies, pharmaceutical industry, and diagnostic and therapeutic support services). The results are analyzed in four categories: size, performance, indebtedness, and relevance of financial operations. The results were compared to the overall results for large and open-capital corporations in Brazil. The study reveals central aspects of financialization such as the sector’s growth, the expansion of leading companies, and capital centralization, corroborating hypotheses concerning the concentration and centralization of capital. Other hypotheses, such as the relevant impacts of financial operations on revenues, were not confirmed. Finally, the evidence provided by a strictly accounting-based analysis suggest the need to incorporate other dimensions, especially such strategies as mergers, acquisitions, and other equity operations.
DOI: 10.6084/m9.figshare.20677016
title: Electrochemical immunosensor for detection of Plasmodium vivax lactate dehydrogenase

description: BACKGROUND Malaria is a disease that affects many tropical and subtropical countries, including Brazil. The use of tests for malaria detection is one of the fundamental strategies recommended by the World Health Organization for the control and eradication of the disease. The lack of diagnostic tests leads to an increase in transmission and non-reporting cases. OBJECTIVES This work described an electrochemical immunosensor for detecting Plasmodium vivax lactate dehydrogenase antigen (Ag-PvLDH). METHODS The device has developed by immobilising egg yolk IgY antibodies (Ab-PvLDH) on a gold electrode surface using cysteamine as linker. The immunosensor fabrication was followed by differential pulse voltammetry, and contact angle measurements were performed to characterise the modified gold electrode surface. FINDINGS The results for Ag-PvLDH determination exhibit a linear response at 10-50 µg mL-1 concentration range, with a limit of detection of 455 ng mL-1. The excellent selectivity of the device was confirmed. MAIN CONCLUSIONS The developed immunosensor showed a good performance, therefore, it can be considered an alternative test to detect malaria caused by P. vivax.