cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60645/bdc-005e-8fp1
title: Acute Respiratory Distress Network (ARDSNet) Studies 10 and 12 Statins for Acutely Injured Lungs from Sepsis (SAILS) (ARDSNet-SAILS-BioLINCC)

description: 
**<u>Data Access NOTE:</u>** Please refer to the &#8220;Authorized Access&#8221; section below for information about how access to the data from this accession differs from many other dbGaP accessions. 

<u>Biospecimens </u><br>Access to Biospecimens is through the NHLBI Biologic Specimen and Data Repository Information Coordinating Center ([BioLINCC](https://biolincc.nhlbi.nih.gov/home/)). Biospecimens from ARDSNet-SAILS include Plasma, DNA, and Urine. Please note that use of biospecimens in genetic research is subject to a tiered consent. 

<u>Objectives </u><br>The SAILS trial was intended to assess the efficacy and safety of oral rosuvastatin in participants with sepsis-induced Acute Lung Injury (ALI) and test the hypothesis that rosuvastatin therapy would improve the clinical outcomes of critically ill participants with sepsis-associated acute respiratory distress syndrome (ARDS). 

<u>Background </u><br>In ARDS, inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses. Previous observational studies suggested that statins improved clinical outcomes in participants with sepsis. 

<u>Participants </u><br>There were 745 participants. 

<u>Design </u><br>Participants were randomly assigned in permuted blocks to receive either enteral rosuvastatin or placebo. A 40 mg loading dose of the study drug was administered within four hours after randomization. Subsequently, maintenance doses of 20 mg were administered daily until the third day after discharge from the intensive care unit, study day 28, hospital discharge, or death, whichever came first. The primary outcome measure was mortality before hospital discharge home or until study day 60 if the participant was still in a health care facility. Secondary outcome measures included the number of ventilator-free days to day 28, organ-failure-free days to day 14, and ICU-free days to day 28. 

<u>Conclusions </u><br>The study was stopped because of futility after 745 of an estimated 1000 participants had been enrolled. There was no significant difference between study groups in 60 day in-hospital mortality or in mean ventilator-free days. The rosuvastatin group had fewer days free of hepatic or renal failure. Thus, rosuvastatin therapy did not improve clinical outcomes in participants with sepsis-associated ARDS and may have contributed to hepatic and renal organ dysfunction.
DOI: 10.5517/ccdc.csd.cc2nyctt
title: CCDC 2471097: Experimental Crystal Structure Determination

description: Related Article: Srinivasarao Yaragorla, Liyaqat Ali|2026|Chem.-Eur.J.|32|e03306|doi:10.1002/chem.202503306
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nycvv
title: CCDC 2471098: Experimental Crystal Structure Determination

description: Related Article: Srinivasarao Yaragorla, Liyaqat Ali|2026|Chem.-Eur.J.|32|e03306|doi:10.1002/chem.202503306
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60645/bdc-568u-sao3
title: Incentives and Case Management to Improve Cardiac Care: Healthy Lifestyle Program (HeLP)

description: None
DOI: 10.5517/ccdc.csd.cc2nz921
title: CCDC 2471973: Experimental Crystal Structure Determination

description: Related Article: Altaf Husain, Nissar Hussain, Shaikh M. Mobin|2026|J.Mater.Chem.A|||doi:10.1039/d5ta09288d
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nz9vt
title: CCDC 2471997: Experimental Crystal Structure Determination

description: Related Article: Altaf Husain, Nissar Hussain, Shaikh M. Mobin|2026|J.Mater.Chem.A|||doi:10.1039/d5ta09288d
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2p4b39
title: CCDC 2476810: Experimental Crystal Structure Determination

description: Related Article: N. A. Shimin, L. B. Serezhkina, M. S. Grigoriev, A. V. Savchenkov, V. N. Serezhkin|2025|Russ.J.Coord.Chem.|51|904|doi:10.1134/S107032842560113X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2p4b4b
title: CCDC 2476811: Experimental Crystal Structure Determination

description: Related Article: N. A. Shimin, L. B. Serezhkina, M. S. Grigoriev, A. V. Savchenkov, V. N. Serezhkin|2025|Russ.J.Coord.Chem.|51|904|doi:10.1134/S107032842560113X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2p5mgz
title: CCDC 2478061: Experimental Crystal Structure Determination

description: Related Article: Siying Chen, Junli Yang, Shuaijie Liu, Yehong Huo, Xin Cheng, Lingling Li, Wei Ji|2026|Chemical Science|||doi:10.1039/d5sc07918g
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2p5z1x
title: CCDC 2478389: Experimental Crystal Structure Determination

description: Related Article: M. D. Gotsko, N. A. Korobeinikov, S. S. Opanasyuk, S. A. Adonin|2026|Russ.J.Coord.Chem.|51|899|doi:10.1134/S107032842560127X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2p5z2y
title: CCDC 2478390: Experimental Crystal Structure Determination

description: Related Article: M. D. Gotsko, N. A. Korobeinikov, S. S. Opanasyuk, S. A. Adonin|2026|Russ.J.Coord.Chem.|51|899|doi:10.1134/S107032842560127X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pbk9x
title: CCDC 2482799: Experimental Crystal Structure Determination

description: Related Article: Prashant Kaushik, Kuldeep Mahiya, Mandeep, Presenjit, Ritika, Vinod Kumar, Ajay Kumar Mishra, Swaraj Kumar Babu, Pradeep Kumar Naik, Ravinder Kumar|2026|J.Mol.Struct.|1353|144662|doi:10.1016/j.molstruc.2025.144662
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pcrvp
title: CCDC 2483963: Experimental Crystal Structure Determination

description: Related Article: Sayanta Roy, Gobinda Dolai, SK Ariyan, Bhubaneswar Mandal|2026|RSC Advances|16|5466|doi:10.1039/d5ra08605a
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pcrwq
title: CCDC 2483964: Experimental Crystal Structure Determination

description: Related Article: Sayanta Roy, Gobinda Dolai, SK Ariyan, Bhubaneswar Mandal|2026|RSC Advances|16|5466|doi:10.1039/d5ra08605a
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pdfm5
title: CCDC 2484607: Experimental Crystal Structure Determination

description: Related Article: R.Ya. Okmanov, A.A. Ziyaev, T.T. Toshmurodov, U.S. Makhmudov, A.G. Eshimbetov, S.A. Sasmakov, B. Tashkhodzhaev|2025|Chem. Data Collect.|60|101212|doi:10.1016/j.cdc.2025.101212
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pdfn6
title: CCDC 2484608: Experimental Crystal Structure Determination

description: Related Article: R.Ya. Okmanov, A.A. Ziyaev, T.T. Toshmurodov, U.S. Makhmudov, A.G. Eshimbetov, S.A. Sasmakov, B. Tashkhodzhaev|2025|Chem. Data Collect.|60|101212|doi:10.1016/j.cdc.2025.101212
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pdfp7
title: CCDC 2484609: Experimental Crystal Structure Determination

description: Related Article: R.Ya. Okmanov, A.A. Ziyaev, T.T. Toshmurodov, U.S. Makhmudov, A.G. Eshimbetov, S.A. Sasmakov, B. Tashkhodzhaev|2025|Chem. Data Collect.|60|101212|doi:10.1016/j.cdc.2025.101212
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pdfq8
title: CCDC 2484610: Experimental Crystal Structure Determination

description: Related Article: R.Ya. Okmanov, A.A. Ziyaev, T.T. Toshmurodov, U.S. Makhmudov, A.G. Eshimbetov, S.A. Sasmakov, B. Tashkhodzhaev|2025|Chem. Data Collect.|60|101212|doi:10.1016/j.cdc.2025.101212
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qs7g7
title: CCDC 2525739: Experimental Crystal Structure Determination

description: Related Article: Huimin Xing, Jiangmei Chen, Chunyu Tao, Yun Zhao, Haifang Mao, Jian Xu, Wei Wang, Guoqing Wang, Miaomiao Jin|2026|Journal of Chemical Engineering Data|||doi:10.1021/acs.jced.5c00575
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qsp18
title: CCDC 2526160: Experimental Crystal Structure Determination

description: Related Article: Constantin G. Daniliuc, Thomas Özgün, Roland Fröhlich, Gerhard Erker|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qspbk
title: CCDC 2526169: Experimental Crystal Structure Determination

description: Related Article: Constantin G. Daniliuc, Xin Xu, Gerhard Erker|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qt10m
title: CCDC 2526500: Experimental Crystal Structure Determination

description: Related Article: Constantin G. Daniliuc, Philipp Feldhaus, Roland Fröhlich, Gerhard Erker|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qt4c2
title: CCDC 2526604: Experimental Crystal Structure Determination

description: Related Article: Constantin G. Daniliuc, Markus Erdmann, Roland Fröhlich, Gerhard Erker
|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qt6rj
title: CCDC 2526678: Experimental Crystal Structure Determination

description: Related Article: Constantin G. Daniliuc, Olga Ekkert, Roland Fröhlich, Gerhard Erker|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qt7sl
title: CCDC 2526710: Experimental Crystal Structure Determination

description: Related Article: Constantin G. Daniliuc, Olga Ekkert, Roland Fröhlich, Gerhard Erker|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qtcdb
title: CCDC 2526822: Experimental Crystal Structure Determination

description: Related Article: Huber, Alexander, Wölper, Christoph, Voskuhl, Jens|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qtcjg
title: CCDC 2526826: Experimental Crystal Structure Determination

description: Related Article: Abozolof, Jarmok, Wölper, Christoph, Giese, Michael|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2qtckh
title: CCDC 2526827: Experimental Crystal Structure Determination

description: Related Article: Abozolof, Jarmok, Blanke, Meik, Wölper, Christoph, Giese, Michael|2026|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60645/bdc-853o-71g7
title: Acute Respiratory Distress Network (ARDSNet) Studies 06 and 08 Prospective, Randomized, Multicenter Trial of Aerosolized Albuterol Versus Placebo for the Treatment of Acute Lung Injury (ALTA) (ARDSNet-ALTA-BioLINCC)

description: 
**<u>Data Access NOTE:</u>** Please refer to the &#8220;Authorized Access&#8221; section below for information about how access to the data from this accession differs from many other dbGaP accessions. 

<u>Biospecimens </u><br>Access to Biospecimens is through the NHLBI Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC). Biospecimens from ARDSNet-ALTA include Plasma, DNA, Urine, and BAL. Please note that use of biospecimens in genetic research is subject to a tiered consent. 

<u>Objectives </u><br>This clinical trial was designed to test the hypothesis that an aerosolized beta-2-agonist, albuterol, would improve clinical outcomes in participants with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). 

<u>Background </u><br>In participants with acute lung injury and acute respiratory distress syndrome (ALI/ARDS), inflammation of the pulmonary circulation increases vascular permeability. Fluid leaks from blood vessels into the pulmonary interstitium and alveoli. Recovery from this form of acute respiratory failure requires that the pulmonary edema resolve. The resolution of alveolar edema is driven by active transport of sodium and chloride ions from the luminal space across both type I and type II alveolar epithelial cells, creating an osmotic gradient for the reabsorption of water. In the ex vivo human lung, the rate of alveolar fluid clearance can be doubled by treatment with a cyclic AMP beta-2 adrenergic receptor agonist. 

On the basis of the preclinical observations that treatment with beta-2-agonists could reduce pulmonary edema and accelerate the rate of alveolar fluid clearance, the ALTA study was designed and undertaken with the hypothesis that treatment of participants with ALI/ARDS with beta-agonist therapy would accelerate the resolution of alveolar edema and improve clinical outcomes. 

<u>Participants </u><br>There were 282 participants. 

<u>Design </u><br>Study staff conducted a multicenter, randomized, placebo-controlled clinical trial in which participants were randomized to receive aerosolized albuterol (5 mg) or saline placebo every 4 hours for up to 10 days. The primary outcome variable for the trial was ventilator-free days. 

<u>Conclusions </u><br>Ventilator-free days were not significantly different between the albuterol and placebo groups. The results suggest that aerosolized albuterol does not improve clinical outcomes in participants with ALI. Routine use of beta-2 agonist therapy in mechanically ventilated participants with ALI cannot be recommended (Matthay, et al., 2011, PMID: [21562125](https://pubmed.ncbi.nlm.nih.gov/21562125/)).
DOI: 10.60645/bdc-iue7-2f2y
title: Jackson Heart Study - Images

description: 
The Jackson Heart Study (JHS) is a large, community-based, observational study that recruited 5,306 African American adults from three counties (Hinds, Madison and Rankin) in the Jackson, MS area. Participants age 35-84 years at baseline were enrolled from each of 4 recruitment pools: (1) random, 17%, (2) volunteer, 30%, (3) currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 31%, and (4) secondary family members, 22% (family study participants were age&#8805;21 years). Data available include medical history, physical examination, blood/urine analytes, and interview questions on areas such as physical activity, stress, coping and spirituality, racism and discrimination, socioeconomic position, and access to health care. Extensive clinical phenotyping includes anthropometrics, electrocardiography, carotid ultrasound, ankle-brachial blood pressure index, echocardiography, CT chest and abdomen for coronary and aortic calcification, liver fat, subcutaneous and visceral fat measurements, and cardiac MRI. Participants have been contacted annually by telephone to update information, confirm vital status, document interim medical events, hospitalizations and functional status, and obtain sociocultural information. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths.