cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/9gsndvdjw3
title: TRIM25 phase separation drivers the RIG-I activation and restricted by influenza A virus NS1 to mediate immune evasion

description: ere we show that tripartite motif-containing protein 25 (TRIM25), a critical E3 ubiquitin ligase of RIG-I, undergoes LLPS in cells. And the intermolecular poly-hydrogen bond at 244-249 (-EY-EMK-) in the disordered region in coiled coil domain mediating its dimerization is important for TRIM25 phase separation. TRIM25 LLPS significantly weakened by amino acid mutations at 244-249 abolishes the activation of RIG-I K63 ubiquitination, type I interferon production and fails to inhibit influenza A virus (IAV) replication in human A549 cells. Furthermore, we found that initial TRIM25 at a liquid-like state is required for the formation of RIG-I signaling condensates and serves as microreactors to bind to dsRNA and recruits RIG-I, and subsequently catalyzes K63 ubiquitination of RIG-I to trigger downstream signaling activation. Intriguingly, IAV nonstructural protein 1 (NS1) undergoes LLPS under transfection or PR8-GFP virus infection states. NS1 protein was able to form condensates with TRIM25 more preferentially than RIG-I and led to the solidification of TRIM25, consequently blocks the formation of TRIM25 with RIG-I condensates and mediating immune evasion. Our results demonstrate that the TRIM25 LLPS drives the RIG-I signaling activation and also provides new perspectives for understanding mechanism for how viruses overcome innate immunity.
DOI: 10.5281/zenodo.14782854
title: Fram Strait: Possible key to saving Arctic ice

description: This repository contains the data, figures and code used for analysis and visualization in the study by Detelina Ivanova and co-authors, titled “Fram Strait: Possible key to saving Arctic ice,” which is submitted for publication in Journal of Forntiers in Climate: Climate Adaptation (January 2025).

The repository includes:



Processed climate model output: Data from CESM1.2 climate simulations conducted for the study by the authors. It contains processed model output from CAM (atmospheric model component) and CICE (sea ice model component) and Fram Strait Export extracted and calculated from the CICE model data.

Data formats: The data are stored in NETCDF and CSV formats.

Analysis and visualization code: Scripts written in NCAR Command Language (NCL) and Matlab by Detelina Ivanova.


This repository serves as the primary resource for reproducing the analyses and visualizations presented in the manuscript.
DOI: 10.5281/zenodo.14782855
title: Fram Strait: Possible key to saving Arctic ice

description: This repository contains the data, figures and code used for analysis and visualization in the study by Detelina Ivanova and co-authors, titled “Fram Strait: Possible key to saving Arctic ice,” which is submitted for publication in Journal of Forntiers in Climate: Climate Adaptation (January 2025).

The repository includes:



Processed climate model output: Data from CESM1.2 climate simulations conducted for the study by the authors. It contains processed model output from CAM (atmospheric model component) and CICE (sea ice model component) and Fram Strait Export extracted and calculated from the CICE model data.

Data formats: The data are stored in NETCDF and CSV formats.

Analysis and visualization code: Scripts written in NCAR Command Language (NCL) and Matlab by Detelina Ivanova.


This repository serves as the primary resource for reproducing the analyses and visualizations presented in the manuscript.
DOI: 10.17632/3m9rxfznpm
title: LDHU3_20.1850

description: SET domain-containing protein; Leishmania donovani (HU3 strain)
DOI: 10.17632/77r6w44xbp
title: Dataset_linear generalized model_barley

description: The dataset includes meteorological and energy balance measurements to train and validate a linear generalized model (GLM) to estimate daily actual evapotranspiration on a barley crop. Measurements were taken in eastern Argentine Pampas (La Alcira station: 37,49ºS, 58,90º W, 186 m.a.s.l.). The file MethodsX_Notebook includes the routines of the model.
DOI: 10.17632/zy9r99mzgs
title: Compilation of ages, trace element and Nd-Hf-Sr-Pb isotope geochemistry of Cenozoic basalts in the South China Sea tectonic domain.

description: In recent studies, we have confirmed that the OIBs and N-MORBs accreted in the Hengchun accretionary prism (Hengchun Peninsula, southern Taiwan) are debris of the oceanic crust and seamount in the subducted South China Sea. This enables us to evaluate the contributions from the recycled oceanic crust and the Hainan Plume to Cenozoic basalts in the South China Sea region via investigating a compilation of geochemical and isotopic data. From a macroscopic perspective, we identified a regional mantle heterogeneity boundary approximately in accordance with the Red River – Zhongnan Fault system, and a specious FOZO-like mantle component, which are resulted from the subduction, stagnation and recycling of (paleo-)Pacific oceanic slab. Additionally, we attributed the carbonated melts (with high U/Pb and low Th/U ratios) emerged at about 25 Ma to the influence of the Hainan Plume. These findings shed new light on the understanding of the tectonic-magmatic evolution in the South China Sea region.
DOI: 10.17632/ky4yxk9mc7
title: Unexpectedly high fluxes of phosphorus and iron at the sediment-water interface during the frozen period

description: This is a compilation of data on DGT-labile phosphorus and iron at the sediment-water interface for 11 sampling sites in the Xingkai Lake watershed during winter and spring, as well as HR-Peeper data.
DOI: 10.17632/vcj5gm8nhc
title: Raw data: Ecotoxicological Effects of the Herbicide Metribuzin on Tenebrio molitor Hemocyte

description: Herbicides are synthetic chemicals that are extensively employed in agricultural practices with the objective of enhancing crop yield and quality. Despite their selectivity for plant systems and being generally regarded as non-toxic to animals, there is a paucity of understanding surrounding the sublethal effects on non-target organisms, including animals. This gap underscores the necessity for ecotoxicological research that prioritizes the identification of suitable models and develops reliable biomarkers for the early assessment of environmental impact. In this context, hemocytes—circulating immune cells found in invertebrates—have been identified as a crucial system for assessing sublethal toxicological effects, given their role in immune defense and overall organism health. Tenebrio molitor, a beetle pest of stored grain, was used as a model for the assessment of the effects of a metribuzin-based herbicide (MTB, Feinzin DF 70, 70% metribuzin, 0.25 kg/ha). Following a 96 h exposure to MTB, the males (7–10 days post-eclosion) were examined for multiple biomarkers in their hemocytes, including cell density, phagocytic activity, lysosomal membrane stability, and cytological changes. Although no mortality was observed, exposure to MTB resulted in a reduction in the phagocytic index and an increase in blast-like cells, indicating the potential for immunotoxicity. Lysosomal membrane stability was reduced, though no significant changes in hemocyte density or nuclear morphology were observed. These responses indicate potential immune system impairment, which could affect the beetle’s fitness and reproductive potential. This study highlights the potential of hemocytes for assessing sublethal herbicide effects, raising concerns about the ecological impact of herbicides in agroecosystems and their potential risks to both wildlife and human health.

Keywords: agrochemicals; alternative models; apoptosis; biomarkers; cytotoxicity; hematology; immunocompetence; insects; neutral red assay 


Vommaro, M.L.; Guadagnolo, M.; Lento, M.; Giglio, A. Ecotoxicological Effects of the Herbicide Metribuzin on Tenebrio molitor Hemocytes. Environments 2025, 12, 30. https://doi.org/10.3390/environments12010030
DOI: 10.17632/3786tx9y9b
title: Dentin Erosion and Proteolytic Activity: Evaluating MMP Inhibition Strategies through a Systematic Review.

description: Systematic searches were conducted in PubMed, Scopus, and Web of Science databases up to December 2024. Inclusion criteria included in vitro and in situ studies published in English or Spanish that investigated MMP or cathepsin activity in eroded or erosion-abrasion dentin. Risk of bias was assessed using a modified Cochrane tool adapted for in vitro studies. Thirteen studies met the inclusion criteria. Of these, 10 were in vitro, 2 were in situ, and 1 used a combined in vitro/in vivo design. Risk of bias assessment showed that 85% of the included studies had a low risk of bias, with the remainder exhibiting moderate risk due to unclear randomization or incomplete outcome reporting.
DOI: 10.17632/2bnh588j4v
title: Coaching to Improve Colorectal Cancer Screening Equity (CoachIQ)

description: This dataset includes clinical organization-reported data on organizational characteristics, evidence-based intervention use, patient characteristics, and colorectal cancer screening rates at the CoachIQ pilot study baseline. The data were collected in early 2023 from six clinical organizations.
DOI: 10.17632/tvpwwrj6rr
title: Parenting in crisis

description: The database contains partial survey data from the ‘Parenting in Times of Crisis’ project.
DOI: 10.17632/zdyx4zsvw9
title: BMAC Dataset - 'Proteomic Analysis of BMAC from the Iliac Crest and Humeral Head Using Support Vector Machines'

description: Dataset contains antibody microarray data used in the following work: 'Proteomic Analysis of BMAC from the Iliac Crest and Humeral Head Using Support Vector Machines'.
DOI: 10.15468/dl.2xcp6t
title: Occurrence Download

description: A dataset containing 2194 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phaeocystis globosa Scherffel, 1899"
 ]
}

 The dataset includes 2194 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007126-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/2vwv7w37j5
title: RT-qPCR assessment of mRNA expression (ERBB4, NRG4 and major lipogenesis genes) in human liver with histologic liver images and biochemical analysis of blood serum

description: ERBB4 and NRG4 have been shown to ameliorate steatosis and prevent the development of non-alcoholic steatohepatitis in mouse models, but little to nothing is known about their role in non-alcoholic fatty liver disease (NAFLD) in humans. This data is the first expression study of ERBB4, NRG4, ACACA, FASN, FTO, SREBF1 and TFEB mRNAs in the liver biospecimens of individuals with obesity, type 2 diabetes and biopsy-proven NAFLD. 
Against a background of increased BMI, ERBB4 and NRG4 mRNA levels decreased, while ACACA mRNA levels increased. No deregulation of the analyzed transcripts was detected in NAFLD (link to the article). 

The data also contains information on detailed blood biochemical parameters, the anthropometric information (including diagnosis) and liver histology images that can be used for various meta-analyses and the development of prognostic biomarkers. 

Verification of the diagnosis of patients was performed at the Regional Clinical Hospital in Kaliningrad, Russia. Patients underwent standard dietary adjustments before elective abdominal surgery, which was performed under general anesthesia. All obese patients discontinued medications affecting carbohydrate and lipid metabolism parameters 36 hours before surgery. A fasting blood sample was obtained the morning before surgery. During surgery, liver samples of up to 0.5 mL were collected for RNA extraction (immediately placed in 600 μL RNAlater solution (Ambion, USA)) and up to 1 mL for histologic analysis (immediately fixed in 5 mL neutral buffered formalin). The study was conducted in accordance with the World Medical Association Declaration of Helsinki (2000) and the Protocol to the Convention on Human Rights and Biomedicine (1999). The study was approved by the local ethics committee of the Immanuel Kant Baltic Federal University: IKBFU Ethics Committee Conclusion №40 of 26.06.2023. All of the participants provided signed informed consent. All interventions were performed by highly qualified medical professionals and posed no risk to the patients' health.

Inclusion criteria: individuals over 21 years who have received a diagnosis of their health condition from an official healthcare provider and have been referred for planned abdominal surgery, and who declared their willingness to participate in the study and donate a small tissue sample and their blood by giving informed written consent. 

Exclusion criteria: presence of infectious liver disease, concomitant somatic and infectious diseases in the acute inflammatory stage, presence of a known HIV infection, presence of malignant or benign neoplasms, age under 21 years, refusal to undergo medical and laboratory examinations during the study, or refusal to sign the informed consent form.
DOI: 10.17632/rphcz68bxb
title: Youngest Leopard Cub Ever Found in a Tree Hole with Mother at Yala National Park, Sri Lanka: A Rare Sighting

description: Abstract
Introduction: The Sri Lankan leopard (Panthera pardus kotiya) is a sub species of the Panthera pardus family. It inhabits a variety of island’s habitats ranging from tropical rainforests to arid zone scrublands. This report documents the rare sighting of a newborn Sri Lankan leopard cub observed with its mother in a tree hole within Yala National Park, Sri Lanka. 

Results: On April 7, 2023, a female leopard and a newborn cub: estimated to be less than 10 days old, were sighted in a tree hole located approximately 15 feet above ground level. The mother leopard was observed nursing and grooming the cub, exhibiting relaxed yet vigilant behavior. The interaction was captured through high-resolution photography, capturing this rare display of maternal care and habitat use. Subsequent observations, including a follow-up sighting in 2024, indicated that the cub has continued to thrive, highlighting successful mother-cub bonding and survival.

Discussion: This sighting marks the youngest leopard cub ever documented in the Yala National Park, Sri Lanka and highlights the suitability for leopard breeding within the ecosystem. These observations contribute to understanding critical aspects of leopard maternal care and habitat requirements, which impact the cub survival during early life. Continued conservation and research in Sri Lanka’s protected areas are essential to ensure the survival of this vulnerable species and its future within the island’s ecosystems.
DOI: 10.17632/xrw2n58zkh
title: LINF_040006500

description: Protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/92v9vzth8v
title: Data for: The 18S–25S ribosomal RNA unit of yerba mate (Ilex paraguariensis A. St.-Hil.)

description: This dataset contains the supplementary material of the article at Plant Biosystems entitled "The 18S–25S ribosomal RNA unit of yerba mate (Ilex paraguariensis A. St.-Hil.)" by Aguilera et al. The dataset consists of 8 files. By the time this article was published this dataset was deposited at "https://drive.google.com/folderview?id=0B3Hl6DDYmVW6Q2d2MHRQdUJFRTQ&usp=sharing", however this link is currently is unavailable.
DOI: 10.17632/92x2r52j3m
title: A temperature and material-dependent model for the lateral spread during hot rolling of steels utilizing an artificial neural network

description: This dataset includes all data and source codes in Fortran, Python and Matlab for the manuscript "A temperature and material-dependent model for the lateral spread during hot rolling of steels utilizing an artificial neural network"
DOI: 10.17632/p6sz83bd3x
title: Data for: NOVEL SPRUE DESIGNS IN METAL CASTING via 3D SAND-PRINTING

description: SEM, EDS and Mechanical Test Data from 3DSP Castings
DOI: 10.17632/96ynr52vwh
title: One step hydrothermal synthesis of green Iron-Modified Catalyst by food waste biogas residue for Ozonation of Ciprofloxacin: Characterization, Degradation Mechanism, DFT study and Reactive Oxygen Species role

description: Recently, Biogas has been a well-known energy source due to global energy crises and huge urban leftover food waste by hospitality or food delivery. Still, it produces untreated biogas residue (BR), which causes heavy metals, and hazardous compounds leaching. Additionally, the proliferation of antibiotics such as ciprofloxacin (CIP) in the dairy and veterinary industry results in continuous release into water, posing a serious threats to ecological health. Herein, this study presents the hydrothermal synthesis of a series of Iron (Fe)-modified catalysts derived from eco-friendly ball milling boosted biogas residual biochar (BRB) to remove CIP via catalytic ozonation degradation. Fe-modified biochar with 2.5 wt. % iron loading and synthesized at 240 ℃ (2.5Fe-FBRB-240 ℃) exhibited the highest removal efficiency of 98.61% and stability for ten cycles of 20 min each. An optimal catalyst has demonstrated potential for CIP degradation in river and tap water, and ICP-MS has shown safer Fe-leaching. Toxicity assessment, mechanism, and degradation pathways were also proposed. Electrochemical studies, density functional theory (DFT) calculations, and Electron paramagnetic resonance (EPR) analysis confirmed the involvement of electron transfer and reactive oxygen species, like hydroxyl radicals (•OH), sulfate radicals (SO4•−), and singlet oxygen (1O2) in CIP degradation. This study provides a novel perspective for eliminating organic contaminants using biogas residue biochar-based catalysts.
DOI: 10.17632/cjyww43m5h
title: Intergovernmentalism and lateral pressure version two

description: Intergovernmentalism and lateral pressure version two
DOI: 10.17632/c3czjzkp2t
title: LINF_040006200

description: Protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/2y9vjt3kyw
title: dipole moment fluctuation (angle, magnitude, and RMSF) data of CRBP-atREA complexes (wild-type, Q108R)

description: 1. input files (GROMACS dipole moment dataset)
'dipoles_pbc_nojump_0_50_dt10_rxx.xvg' 

2. MATLAB source code
'dipole_fluc.m'

3. Output files
'mean_angfluc.txt' and 'std_angfluc.txt' : angle fluctuations between residues and ligand dipoles
'mean_magfluc.txt' and 'std_magfluc.txt' : magnitude fluctuations of dipole moment of residues
'dRMSF_res.txt' : dipole moment RMSF of the protein
DOI: 10.17632/2ktsr76452
title: Color measurement of butter available on the Polish market

description: The data was obtained by analyzing butters available on the Polish market. Based on the manufacturer's data, the following information was entered: taste, ingredients, fat content (including saturated fatty acids), carbohydrates (including sugars), protein, salt. The color coordinates L, a*, b* and X, Y, Z were measured in the SPIN and SPEX system. On the basis of the L coordinates (lightness), a* and b*, the following were calculated: (WI) white index, (YI) yellowness index, (C) chroma, (BI) brownness index.
DOI: 10.17632/n46bm9ct42
title: How Election Cycles Influence Automation Adoption: A Comparative Study of Public and Private Sector Policies in the U.S

description: This dataset examines how U.S. electoral cycles influence automation adoption trends in the public and private sectors. Drawing on a mixed-method approach, the data combine longitudinal quantitative analysis of automation rates over the period 2000–2020 with qualitative insights from semi-structured interviews with 30 decision-makers. Significant increases in public sector automation are seen after the election, given the policy for modernization by an incoming administration, while private sector investments in automation are much lower during the pre-election period due to uncertainty over future regulations. The current study fills an important gap between political economy and technological adoption by providing empirical evidence and practical recommendations for policymakers and business executives. These drivers include regulatory uncertainty and an electoral mandate; a dataset on the trends, regression analyses, and thematic insights was drawn upon.
DOI: 10.17632/zxbp2zhz4x
title: Axin2, GSK3B data

description: Pathogenic bacteria located in the vagina and cervix have the potential to migrate to the endometrium and induce a proinflammatory cytotoxic response in the endometrial cavity, potentially damaging the embryo or preventing its implantaPathogenic bacteria located in the vagina and cervix have the potential to migrate to the endometrium and induce a proinflammatory cytotoxic response in the endometrial cavity, potentially damaging the embryo or preventing its implantation. The predominant Lactobacillus species act to suppress the growth of other pathogenic bacteria in the vaginal environment. Alterations in Wnt signaling-related genes, such as GSK3β and Axin2, have been significantly implicated in recurrent miscarriage.
Given the importance of understanding the complex mechanisms governing uterine tissue function and factors affecting embryo implantation, along with evidence that demonstrates the role of the vaginal bacterial flora in the continuation of pregnancy, in this study we investigated the changes in the expression of the above two genes in an endometrial cell line (ENSC) with the aim of investigating the effect of Lactobacillus crispatus extract on them. 
Our research showed that the bacteria has positive influence on the expression of some of Wnt1 pathway genes. Axin2 gene had significantly higher expression than that of GSK3β. No significant alterations in gene expression were detected in the untreated ENSC cell lines. 
tion. The predominant Lactobacillus species act to suppress the growth of other pathogenic bacteria in the vaginal environment. Alterations in Wnt signaling-related genes, such as GSK3β and Axin2, have been significantly implicated in recurrent miscarriage.
Given the importance of understanding the complex mechanisms governing uterine tissue function and factors affecting embryo implantation, along with evidence that demonstrates the role of the vaginal bacterial flora in the continuation of pregnancy, in this study we investigated the changes in the expression of the above two genes in an endometrial cell line (ENSC) with the aim of investigating the effect of Lactobacillus crispatus extract on them. 
Our research showed that the bacteria has positive influence on the expression of some of Wnt1 pathway genes. Axin2 gene had significantly higher expression than that of GSK3β. No significant alterations in gene expression were detected in the untreated ENSC cell lines.
DOI: 10.17632/dmf3hxxdmz
title: Data for: Early crust in East Antarctica: Extension from Enderby Land into Kemp Land

description: SIMS and LASS analyses of zircon grains from Aker Peaks.
DOI: 10.17632/nyvtynw9x8
title: Effects of typical vegetation roots on the erosion process of Tarim river bank simulated by BSTEM model

description: Results of toe erosion and bank stability of four roots at four sites.
DOI: 10.17632/54t7jy9z4b
title: LDHU3_20.2160

description: Protein with WD-40 repeats; Leishmania donovani (HU3 strain)
DOI: 10.17632/ff2k2cd66x
title: GENEJOURNAL-D-24-05261R1

description: This document shows the TrMYB130 physiological data and phylogenetic relationship between white clover and Arabidopsis 1R-MYB family members.