cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10057691
title: MOESM1 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 1: Table S1. Primer list. Description of primers required for Sanger sequencing.
DOI: 10.6084/m9.figshare.10057706.v1
title: MOESM3 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 3: Table S3. Deregulated genes after RNA-Sequencing.
DOI: 10.6084/m9.figshare.10057691.v1
title: MOESM1 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 1: Table S1. Primer list. Description of primers required for Sanger sequencing.
DOI: 10.6084/m9.figshare.10057700.v1
title: MOESM2 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 2: Table S2. WES annotation process.
DOI: 10.6084/m9.figshare.10057679
title: MOESM10 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 10: Table S10. Gene variants selected for PanDrugs.
DOI: 10.6084/m9.figshare.10057685
title: MOESM11 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 11: Table S 11. Therapies. Mutations. Deregulation UP. Deregulation DOWN.
DOI: 10.6084/m9.figshare.10057679.v1
title: MOESM10 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 10: Table S10. Gene variants selected for PanDrugs.
DOI: 10.6084/m9.figshare.10057685.v1
title: MOESM11 of The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

description: Additional file 11: Table S 11. Therapies. Mutations. Deregulation UP. Deregulation DOWN.
DOI: 10.6084/m9.figshare.12866429
title: Alignment_Muscle_BED.txt

description: Alignment of Alu-Scan PCR NGS Data to the hg19 Genome
DOI: 10.6084/m9.figshare.12866429.v1
title: Alignment_Muscle_BED.txt

description: Alignment of Alu-Scan PCR NGS Data to the hg19 Genome
DOI: 10.6084/m9.figshare.10057652
title: MOESM2 of PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

description: Additional file 2: Table S1. mRNA PRMT1 expression level (FPKM) and clinical characteristics for all patients and their tumors
DOI: 10.6084/m9.figshare.10057652.v1
title: MOESM2 of PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

description: Additional file 2: Table S1. mRNA PRMT1 expression level (FPKM) and clinical characteristics for all patients and their tumors
DOI: 10.6084/m9.figshare.10057583
title: MOESM1 of Fungi as source for new bio-based materials: a patent review

description: Additional file 1. List of all patents considered in the review.
DOI: 10.6084/m9.figshare.10057583.v1
title: MOESM1 of Fungi as source for new bio-based materials: a patent review

description: Additional file 1. List of all patents considered in the review.
DOI: 10.25375/uct.10057556
title: Faculty perceptions of OER in India 2014-2015, ROER4D Sub-project 3

description: This study aims to map the current preconceptions and behavioural determinants that influence academics’ engagement with Open Educational Resources (OER) in India. The key objectives of this research were to examine teachers’ attitudes towards OER in select Indian universities, establish teacher perspectives on OER use in order to establish the uptake of OER in India, identify barriers to the creation and use of OER in India, identify the factors motivating teachers’ uptake of OER in India, analyse teachers’ perceptions of quality of OER in India, and investigate relationships amongst teachers’ attitudes, motivation, perceptions of quality and barriers to use OER. The project utilised a mixed methods approach consisting of a survey and interviews conducted with academics from four Indian universities. The resultant dataset includes a qualitative component (interview transcripts) and a quantitative component (survey data).<br><br>This published dataset is comprised of the teacher survey instrument and accompanying microdata, and the teacher survey interview schedule with accompanying microdata. Microdata from the 27 interviews conducted have been combined into a single file.<br><br>The dataset is considered to be of potential interest to higher education teachers, administrators and policy-makers in higher education institutions, particularly in the context of India.<br><br>This dataset was first published by DataFirst.<br>
DOI: 10.25375/uct.10057550
title: OER effectiveness in higher education mathematics skills 2014-2015, ROER4D Sub-project 9

description: This study aims to examine the effect of the use of two Open Educational Resources (OER) (a Khan Academy online tutorial and an open textbook hosted on Wikibooks) with respect to the increase of logical-mathematical outcomes of first- and second-year higher education Chilean students. It also aims to uncover teacher and student perceptions about the use of OER in order to understand how these resources are used and valued. For these purposes, quantitative and qualitative methods were used to analyse student performance data and data produced from semi-structured interviews, focus groups and a survey.<br><br>The research process was comprised of a generation of an impact analysis database (regarding student’s performance through grades in a blended-learning mode setting and grades plus attendance in a contact mode setting) followed by student focus group and teacher interviews that led to a student survey. The published dataset does not include the student survey instrument and microdata, as access to this is restricted due to ethical constraints.<br><br>Findings indicate that students in a contact-study mathematics course who used a Khan Academy online mathematics tutorial obtained better examination results than students who did not use any additional resources, or those who used the open textbook. Moreover, it was also found that teachers and students have positive perceptions about the use of Khan Academy and Wikibooks materials.<br><br>This study is Sub-project 9 of the Research on Open Educational Resources for Development (ROER4D) project, hosted by the Centre for Innovation in Learning and Teaching (CILT) at the University of Cape Town, South Africa, and Wawasan Open University, Malaysia.<br><br>The interview data is in Spanish and the impact analysis database is in English. It is considered to be of potential interest to higher education and social science researchers (with a particular focus on Latin America and Chile), as well as policy-makers and advocates of open education policy and practice.<br><br>This dataset was first published by DataFirst.<br>
DOI: 10.25375/uct.10057550.v1
title: OER effectiveness in higher education mathematics skills 2014-2015, ROER4D Sub-project 9

description: This study aims to examine the effect of the use of two Open Educational Resources (OER) (a Khan Academy online tutorial and an open textbook hosted on Wikibooks) with respect to the increase of logical-mathematical outcomes of first- and second-year higher education Chilean students. It also aims to uncover teacher and student perceptions about the use of OER in order to understand how these resources are used and valued. For these purposes, quantitative and qualitative methods were used to analyse student performance data and data produced from semi-structured interviews, focus groups and a survey.<br><br>The research process was comprised of a generation of an impact analysis database (regarding student’s performance through grades in a blended-learning mode setting and grades plus attendance in a contact mode setting) followed by student focus group and teacher interviews that led to a student survey. The published dataset does not include the student survey instrument and microdata, as access to this is restricted due to ethical constraints.<br><br>Findings indicate that students in a contact-study mathematics course who used a Khan Academy online mathematics tutorial obtained better examination results than students who did not use any additional resources, or those who used the open textbook. Moreover, it was also found that teachers and students have positive perceptions about the use of Khan Academy and Wikibooks materials.<br><br>This study is Sub-project 9 of the Research on Open Educational Resources for Development (ROER4D) project, hosted by the Centre for Innovation in Learning and Teaching (CILT) at the University of Cape Town, South Africa, and Wawasan Open University, Malaysia.<br><br>The interview data is in Spanish and the impact analysis database is in English. It is considered to be of potential interest to higher education and social science researchers (with a particular focus on Latin America and Chile), as well as policy-makers and advocates of open education policy and practice.<br><br>This dataset was first published by DataFirst.<br>
DOI: 10.6084/m9.figshare.10055570
title: Investigation of the potential environmental risks of phthalate derivatives designed to be environmentally friendly

description: The biotoxicity and oestrogen activity of Phthalate (PAE) derivatives(table)The reaction barrier of the transition path was calculated(rar).<br>
DOI: 10.6084/m9.figshare.10055570.v2
title: Investigation of the potential environmental risks of phthalate derivatives designed to be environmentally friendly

description: The biotoxicity and oestrogen activity of Phthalate (PAE) derivatives(table)The reaction barrier of the transition path was calculated(rar).<br>
DOI: 10.6084/m9.figshare.10055570.v1
title: Investigation on the potential environmental risks of the phthalate derivatives designed with environmentally friendly in the Environment

description: The biotoxicity and oestrogen activity of Phthalate (PAE) derivatives(table)The reaction barrier of the transition path was calculated(rar).<br>
DOI: 10.6084/m9.figshare.10055438
title: Dataset Path Learning in Down Syndrome using Floor Matrix task

description: The dataset contains all data needed to reproduce the analyses presented in the manuscript titled "Path learning in individuals with Down syndrome: the use of floor matrix task and the role of visuo-spatial individual measures".<br>Labels for variables are quite obvious. A few clarifications and abbreviations are listed below:- Age_months indicate the chronological age in months<br>- SAQ is Everyday Spatial Activity Questionnaire score- PMA-SR-K1 is the Primary Mental Ability-K1 spatial task- GPT is Ghost Picture Test- WM matrix is the Working Memory task (the scores for the simultaneous and sequential versions are in two different columns as indicated)<br>- "Counterbalancing floor matrix task" indicates whether the Floor Matrix task was first performed in the observer condition and then in the map condition, or vice versa<br>
DOI: 10.6084/m9.figshare.10055366
title: Empty

description: Empty
DOI: 10.6084/m9.figshare.10055339
title: Antibacterial activity of a <i>Tribolium castaneum</i> defensin in an <i>in vitro</i> infection model of <i>Streptococcus pneumoniae</i>

description: <i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) is the most common bacterial cause of community-acquired pneumonia. Increasing rates of antibiotic-resistant <i>S. pneumoniae</i> strains impair therapy and necessitate alternative treatment options. In this study, we analysed insect-derived antimicrobial peptides (AMPs) for antibacterial effects on <i>S. pneumoniae</i> in a human <i>in vitro</i> infection model. AMP effects on bacterial growth were examined by colony forming unit (CFU)-assays, and growth curve measurements. Furthermore, cytotoxicity to primary human macrophages was detected by measuring lactate-dehydrogenase release to the supernatant. One AMP (Defensin 1) was tested in a model of primary human monocyte-derived macrophages infected with <i>S. pneumoniae</i> strain D39 and a multi-resistant clinical isolate. Inflammatory reactions were characterised by qPCR and multiplex-ELISA. In total, the antibacterial effects of 23 AMPs were characterized. Only <i>Tribolium castaneum</i> Defensin 1 showed significant antibacterial effects against <i>S. pneumoniae</i> strain D39 and a multi-resistant clinical isolate. During <i>in vitro</i> infection of primary human macrophages with <i>S. pneumoniae</i> D39, Defensin 1 displayed strong antibacterial effects, and consequently reduced bacteria-induced cytokine expression and release. In summary, <i>Tribolium castaneum</i> Defensin 1 showed profound antibacterial effectivity against <i>Streptococcus pneumoniae</i> D39 and a multi-resistant clinical isolate without unwanted cytotoxic or inflammatory side effects on human blood-derived macrophages.
DOI: 10.6084/m9.figshare.10055366.v2
title: Empty

description: Empty
DOI: 10.6084/m9.figshare.10055366.v1
title: The new kid on the block: Immigrant males win big whereas females pay fitness cost after dispersal - data

description: The data for residents and immigrants (successful dispersers) and their offspring using 29 years of monitoring from North American red squirrels (<i>Tamiasciurus hudsonicus</i>) in Yukon, Canada. Data obtained with funding from the Natural Sciences and Engineering Council of Canada, Northern Scientific Training Program, and the National Science Foundation.<br><br>Published. <b>Martinig, A. R.</b>, A. G. McAdam, B. Danzter, J. E. Lane, D. W. Coltman, & S. Boutin. 2019.<i> </i>The new kid on the block: Immigrant males win big whereas females pay fitness cost after dispersal. Ecology Letters (accepted).
DOI: 10.6084/m9.figshare.10055339.v2
title: Antibacterial activity of a <i>Tribolium castaneum</i> defensin in an <i>in vitro</i> infection model of <i>Streptococcus pneumoniae</i>

description: <i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) is the most common bacterial cause of community-acquired pneumonia. Increasing rates of antibiotic-resistant <i>S. pneumoniae</i> strains impair therapy and necessitate alternative treatment options. In this study, we analysed insect-derived antimicrobial peptides (AMPs) for antibacterial effects on <i>S. pneumoniae</i> in a human <i>in vitro</i> infection model. AMP effects on bacterial growth were examined by colony forming unit (CFU)-assays, and growth curve measurements. Furthermore, cytotoxicity to primary human macrophages was detected by measuring lactate-dehydrogenase release to the supernatant. One AMP (Defensin 1) was tested in a model of primary human monocyte-derived macrophages infected with <i>S. pneumoniae</i> strain D39 and a multi-resistant clinical isolate. Inflammatory reactions were characterised by qPCR and multiplex-ELISA. In total, the antibacterial effects of 23 AMPs were characterized. Only <i>Tribolium castaneum</i> Defensin 1 showed significant antibacterial effects against <i>S. pneumoniae</i> strain D39 and a multi-resistant clinical isolate. During <i>in vitro</i> infection of primary human macrophages with <i>S. pneumoniae</i> D39, Defensin 1 displayed strong antibacterial effects, and consequently reduced bacteria-induced cytokine expression and release. In summary, <i>Tribolium castaneum</i> Defensin 1 showed profound antibacterial effectivity against <i>Streptococcus pneumoniae</i> D39 and a multi-resistant clinical isolate without unwanted cytotoxic or inflammatory side effects on human blood-derived macrophages.
DOI: 10.6084/m9.figshare.10055339.v1
title: Antibacterial activity of a <i>Tribolium castaneum</i> defensin in an <i>in vitro</i> infection model of <i>Streptococcus pneumoniae</i>

description: <i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) is the most common bacterial cause of community-acquired pneumonia. Increasing rates of antibiotic-resistant <i>S. pneumoniae</i> strains impair therapy and necessitate alternative treatment options. In this study we analysed insect-derived antimicrobial peptides (AMPs) for antibacterial effects on <i>S. pneumoniae</i> in a human <i>in vitro</i> infection model. AMP effects on bacterial growth were examined by colony forming unit (CFU)-assays, and growth curve measurements. Furthermore, cytotoxicity to primary human macrophages was detected by measuring lactate-dehydrogenase release to the supernatant. One AMP (Defensin 1) was tested in a model of primary human monocyte-derived macrophages infected with <i>S. pneumoniae</i> strain D39 and a multi-resistant clinical isolate. Inflammatory reactions were characterised by qPCR and multiplex-ELISA. In total, antibacterial effects of 23 AMPs were characterized. Only <i>Tribolium castaneum</i> Defensin 1 showed significant antibacterial effects against <i>S. pneumoniae</i> strain D39 and a multi-resistant clinical isolate. During <i>in vitro</i> infection of primary human macrophages with <i>S. pneumoniae</i> D39, Defensin 1 displayed strong antibacterial effects, and consequently reduced bacteria-induced cytokine expression and release. In summary, <i>Tribolium castaneum</i> Defensin 1 showed profound antibacterial effectivity against <i>Streptococcus pneumoniae</i> D39 and a multi-resistant clinical isolate without unwanted cytotoxic or inflammatory side effects on human blood-derived macrophages.
DOI: 10.6084/m9.figshare.10053365
title: A new environment-aware scheduling method for remanufacturing system with non-dedicated reprocessing lines using improved flower pollination algorithm

description: This is the experimental data of the manuscript entitled “A new environment-aware scheduling method for remanufacturing system with non-dedicated reprocessing lines using improved flower pollination algorithm”. All data are generated through computer simulation and saved in the file with csv format. There are 12 instances for these experiments, which cover multiple scales. The datasets show the carbon emission signature, the weights for two objectives, the time to complete the corresponding operations in the corresponding workstations or reprocessing cells. The number of disassembly workstations, reassembly workstations, and reprocessing cells in each reprocessing line, the power consumptions of reassembly workstations and reprocessing cells in idle status and start-stop status, and the start-up time of reassembly workstations and reprocessing cells in each reprocessing line also shows in the datasets.
DOI: 10.6084/m9.figshare.10053374
title: A new environment-aware scheduling method for remanufacturing system with non-dedicated reprocessing lines using improved flower pollination algorithm

description: This is the experimental data of the manuscript entitled “A new environment-aware scheduling method for remanufacturing system with non-dedicated reprocessing lines using improved flower pollination algorithm”. All data are generated through computer simulation and saved in the file with csv format. There are 12 instances for these experiments, which cover multiple scales. The datasets show the carbon emission signature, the weights for two objectives, the time to complete the corresponding operations in the corresponding workstations or reprocessing cells. The number of disassembly workstations, reassembly workstations, and reprocessing cells in each reprocessing line, the power consumptions of reassembly workstations and reprocessing cells in idle status and start-stop status, and the start-up time of reassembly workstations and reprocessing cells in each reprocessing line also shows in the datasets.
DOI: 10.6084/m9.figshare.10053347
title: Corticosterone and progesterone differentially regulate HPA axis and neuroimmune responses to stress in male rats

description: In response to stressor exposure, expression of the inflammatory cytokine interleukin-1β (IL-1) is increased within the paraventricular nucleus of the hypothalamus (PVN). Surgical removal of the adrenal glands (ADX) potentiated stress-induced IL-1 expression, suggesting a role for adrenal-derived hormones in constraining stress-evoked increases in IL-1. While corticosterone (CORT) is a primary factor inhibiting IL-1 expression, progesterone (PROG) is also released by the adrenal glands in male rats in response to stress and also has potent anti-inflammatory properties. This series of studies first established doses of CORT and PROG that adequately recapitulate the normal stress-induced rise, and then tested for individual and combined roles of CORT and PROG in mitigating stress-induced expression of inflammatory genes. We found that CORT injection alone attenuated ADX-induced increases in IL-1 expression and normalized the HPA axis response to stress. In general, PROG replacement had little effect on changes in HPA axis responsivity or stress-induced inflammatory measures. When CORT and PROG were co-administered, a small effect on expression of the decoy receptor, IL-1R2 was observed, suggestive of an anti-inflammatory response. Overall, these results suggest that although CORT is likely to be the primary stress-related hormone responsible for constraining cytokine expression evoked by stress, CORT and PROG may exert certain combined actions that temper stress-induced neuroinflammation.LAY SUMMARYExposure to stress promoted expression of inflammation-related genes in the PVN and BNST. This inflammation was mainly suppressed by the adrenal hormone corticosterone, whereas progesterone had a smaller role in mitigating post-stress inflammation. Exposure to stress promoted expression of inflammation-related genes in the PVN and BNST. This inflammation was mainly suppressed by the adrenal hormone corticosterone, whereas progesterone had a smaller role in mitigating post-stress inflammation.
DOI: 10.6084/m9.figshare.10053347.v1
title: Corticosterone and progesterone differentially regulate HPA axis and neuroimmune responses to stress in male rats

description: In response to stressor exposure, expression of the inflammatory cytokine interleukin-1β (IL-1) is increased within the paraventricular nucleus of the hypothalamus (PVN). Surgical removal of the adrenal glands (ADX) potentiated stress-induced IL-1 expression, suggesting a role for adrenal-derived hormones in constraining stress-evoked increases in IL-1. While corticosterone (CORT) is a primary factor inhibiting IL-1 expression, progesterone (PROG) is also released by the adrenal glands in male rats in response to stress and also has potent anti-inflammatory properties. This series of studies first established doses of CORT and PROG that adequately recapitulate the normal stress-induced rise, and then tested for individual and combined roles of CORT and PROG in mitigating stress-induced expression of inflammatory genes. We found that CORT injection alone attenuated ADX-induced increases in IL-1 expression and normalized the HPA axis response to stress. In general, PROG replacement had little effect on changes in HPA axis responsivity or stress-induced inflammatory measures. When CORT and PROG were co-administered, a small effect on expression of the decoy receptor, IL-1R2 was observed, suggestive of an anti-inflammatory response. Overall, these results suggest that although CORT is likely to be the primary stress-related hormone responsible for constraining cytokine expression evoked by stress, CORT and PROG may exert certain combined actions that temper stress-induced neuroinflammation.LAY SUMMARYExposure to stress promoted expression of inflammation-related genes in the PVN and BNST. This inflammation was mainly suppressed by the adrenal hormone corticosterone, whereas progesterone had a smaller role in mitigating post-stress inflammation. Exposure to stress promoted expression of inflammation-related genes in the PVN and BNST. This inflammation was mainly suppressed by the adrenal hormone corticosterone, whereas progesterone had a smaller role in mitigating post-stress inflammation.