cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29424183
title: <i>HTR2A</i> DNA methylation as a diagnostic biomarker for rheumatoid arthritis: a validation study using targeted sequencing

description: To validate the potential of the serotonin receptor encoded by 5-hydroxytryptamine receptor 2A (HTR2A) cg15692052 DNA methylation as a diagnostic biomarker for rheumatoid arthritis (RA) and its subtypes. MethylTarget<sup>TM</sup> targeted region methylation sequencing technology was employed to analyze the DNA methylation levels of HTR2A cg15692052 in RA, health control, ankylosing spondylitis, psoriatic arthritis, gout, systemic lupus erythematosus, dermatomyositis, and primary Sjögren’s syndrome patients within the region of chr13:46898190~chr13:46897976. Machine learning algorithms were used to analyze data. Compared to the HC group, RA patients and four serological subtypes of RA (RF-negative RA, RF/CCP double-positive, RF/CCP double-negative, and CCP-negative RA) exhibited significantly higher levels of <i>HTR2A</i> cg15692052 methylation (<i>p</i> &lt; 0.05). Methylation levels in RA patients and its four serological subtypes were significantly positively correlated with erythrocyte sedimentation rate or C-reactive protein (<i>p</i> &lt; 0.05). <i>HTR2A</i> cg15692052 methylation levels combined with different clinical features can significantly distinguish RA patients with AUCs ranging from 0.672 to 0.757, RF/CCP double-negative patients with AUCs from 0.825 to 0.966, RF/CCP double-positive RA patients with AUCs from 0.714 to 0.846, and RF-negative RA patients with AUCs from 0.928 to 0.932. The <i>HTR2A</i> cg15692052 DNA methylation level can serve as a diagnostic biomarker for RA and its subtypes. Rheumatoid arthritis is a long-term condition that causes pain, swelling, and stiffness in the joints. Getting an early and accurate diagnosis is very important, but some patients do not show typical signs in regular blood tests, making it hard to detect the disease in time. In this study, we looked at whether a specific chemical change in the body – namely, DNA methylation, which can affect how genes work – could help identify people with rheumatoid arthritis more reliably. We focused on one gene in particular, called HTR2A, and compared this chemical change in people with rheumatoid arthritis, healthy individuals, and people with other joint problems. We found that this signal was noticeably different in people with rheumatoid arthritis, even in those who usually go undetected by common tests. These results suggest that checking for such gene-related changes could help doctors find and treat rheumatoid arthritis earlier, especially in patients who might otherwise be missed.
DOI: 10.6084/m9.figshare.29487714
title: Prevalence of colistin resistance in clinical <i>Klebsiella pneumoniae</i> isolates: a systematic review and meta-analysis

description: <i>Klebsiella pneumoniae</i> commonly causes nosocomial infections, and the rise of colistin-resistant strains poses a significant challenge to public health. This research aims to assess the worldwide prevalence of colistin resistance in <i>K. pneumoniae</i> isolates through a systematic review of scientific literature. We conducted a systematic literature review of relevant studies available in the PubMed, Scopus, and Web of Science databases up to December 2023. Following this, a meta-analysis was performed using Stata software to determine the overall prevalence of colistin resistance in <i>K.</i> <i>pneumoniae</i> isolates and to conduct subgroup analyses. This meta-analysis reviewed 682 studies and found a global prevalence of colistin resistance at 13% among all <i>K.</i> <i>pneumoniae</i> isolates. Notably, the data shows an increase in colistin resistance from 6% in 2010 to 18% in 2023. This study presents evidence of a substantial global prevalence of colistin resistance among clinical isolates of <i>K.</i> <i>pneumoniae</i>. It is recommended to conduct regular surveillance and testing for colistin resistance to effectively monitor and address this public health issue. <i>Klebsiella pneumoniae</i> has increasingly become resistant to various infections, with colistin often regarded as the last line of defense against these resistant strains. The emergence of colistin-resistant isolates poses a significant threat to public health. In this study, we aimed to assess the global prevalence of colistin resistance among <i>K.</i> <i>pneumoniae</i> isolates. We conducted a comprehensive review of relevant studies across three scientific databases, analyzing a total of 682 studies to determine the prevalence of colistin resistance. Our findings reveal a global prevalence rate of 13% for colistin resistance in <i>K.</i> <i>pneumoniae</i> isolates. Notably, this rate has risen from 6% in 2010 to 18% in 2023.To effectively monitor and combat this growing public health concern, we recommend regular surveillance and testing for colistin resistance in clinical settings.
DOI: 10.6084/m9.figshare.29487714.v1
title: Prevalence of colistin resistance in clinical <i>Klebsiella pneumoniae</i> isolates: a systematic review and meta-analysis

description: <i>Klebsiella pneumoniae</i> commonly causes nosocomial infections, and the rise of colistin-resistant strains poses a significant challenge to public health. This research aims to assess the worldwide prevalence of colistin resistance in <i>K. pneumoniae</i> isolates through a systematic review of scientific literature. We conducted a systematic literature review of relevant studies available in the PubMed, Scopus, and Web of Science databases up to December 2023. Following this, a meta-analysis was performed using Stata software to determine the overall prevalence of colistin resistance in <i>K.</i> <i>pneumoniae</i> isolates and to conduct subgroup analyses. This meta-analysis reviewed 682 studies and found a global prevalence of colistin resistance at 13% among all <i>K.</i> <i>pneumoniae</i> isolates. Notably, the data shows an increase in colistin resistance from 6% in 2010 to 18% in 2023. This study presents evidence of a substantial global prevalence of colistin resistance among clinical isolates of <i>K.</i> <i>pneumoniae</i>. It is recommended to conduct regular surveillance and testing for colistin resistance to effectively monitor and address this public health issue. <i>Klebsiella pneumoniae</i> has increasingly become resistant to various infections, with colistin often regarded as the last line of defense against these resistant strains. The emergence of colistin-resistant isolates poses a significant threat to public health. In this study, we aimed to assess the global prevalence of colistin resistance among <i>K.</i> <i>pneumoniae</i> isolates. We conducted a comprehensive review of relevant studies across three scientific databases, analyzing a total of 682 studies to determine the prevalence of colistin resistance. Our findings reveal a global prevalence rate of 13% for colistin resistance in <i>K.</i> <i>pneumoniae</i> isolates. Notably, this rate has risen from 6% in 2010 to 18% in 2023.To effectively monitor and combat this growing public health concern, we recommend regular surveillance and testing for colistin resistance in clinical settings.
DOI: 10.3535/k3s-eep-wh4
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/s55-h7z-z36
title: Bivalvia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vhe-glk-nz2
title: Dibolia Latreille, 1829

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xwm-w7z-dpz
title: Bison C. H. Smith, 1827

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/71j-w45-waa
title: Hibolithes

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/seb-y82-jg7
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bpc-2k8-5sf
title: Protetragonites

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yd0-4v0-z1x
title: †Trilobita

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/1kz-9ec-103
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/237-eyl-1qx
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6gy-za0-tr2
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/79t-8tl-2rz
title: Eremiproetus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xlb-z76-c06
title: Balclutha Kirkaldy, 1900

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hx0-y0y-bed
title: Scalpellum

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/x9h-0fp-a1m
title: Animalia

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/z9j-tel-pez
title: Cervus elaphus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xge-9p1-2ex
title: Equus (Equus) caballus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jzw-4w3-84e
title: †Pachyseris cristata Martin, 1880

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/swk-8ca-eh3
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/j10-94g-hna
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/t74-abm-hnv
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/yrm-q45-3rr
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/071-enc-qsl
title: †Lytoceras subfimbriatum (d'Orbigny, 1841)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/pgw-n93-dda
title: Olcostephanus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4f2-byq-1tq
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/abc-m28-yy8
title: Talpa Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wdb-w18-qdm
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/xav-xem-be2
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2bj-gsz-yd2
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/t95-rq8-nd0
title: Proetus

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/mmw-lzc-s9b
title: †Phylloceratidae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/tmz-kk3-etp
title: †Trilobita

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/c9c-y3y-zfx
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/l5t-q08-fkg
title: †Protetragonites quadrisulcatus (d'Orbigny, 1841)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/r6y-07w-jyn
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cgh-at4-qjc
title: †Protetragonites quadrisulcatus (d'Orbigny, 1841)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hsl-9q0-d0m
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7cm-khx-elc
title: †Chaetetes Fischer, 1830

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/ehg-8fy-qpm
title: Cnidaria

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.r5jgb8
title: Occurrence Download

description: A dataset containing 37244 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Sambucus canadensis)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 37244 records from 304 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020260-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/cc1397qc
title: CCDC 1021782: Experimental Crystal Structure Determination

description: Related Article: S.K.Singh, N.Kumar, A.Kumar, K.S.Bisht, V.S.Parmar, W.Errington|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1630|doi:10.1107/S0108270195002538
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139ts0
title: CCDC 1022342: Experimental Crystal Structure Determination

description: Related Article: V.M.Bolanos-Garcia, M.E.Jaramillo-Flores, K.Panneerselvam, M.Soriano-Garcia|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1641|doi:10.1107/S0108270195001107
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139v9k
title: CCDC 1022358: Experimental Crystal Structure Determination

description: Related Article: J.M.Fernandez-G, A.Rodriguez-Romero, K.Panneerselvam, M.Soriano-Garcia|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1643|doi:10.1107/S0108270195001417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139hmj
title: CCDC 1022027: Experimental Crystal Structure Determination

description: Related Article: K.Panneerselvam, M.Soriano-Garcia|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1646|doi:10.1107/S0108270195002216
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139vbl
title: CCDC 1022359: Experimental Crystal Structure Determination

description: Related Article: J.M.Fernandez-G, A.Rodriguez-Romero, K.Panneerselvam, M.Soriano-Garcia|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1643|doi:10.1107/S0108270195001417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139brh
title: CCDC 1021876: Experimental Crystal Structure Determination

description: Related Article: H.Saitoh, K.Saito, H.Itoh, T.Mochiduki, K.Kikuchi, I.Ikemoto|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1656|doi:10.1107/S0108270195001806
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139k76
title: CCDC 1022077: Experimental Crystal Structure Determination

description: Related Article: D.Cristiano, R.W.Gable, D.A.Lowe, J.Tsanaktsidis|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1658|doi:10.1107/S0108270195002411
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13997y
title: CCDC 1021829: Experimental Crystal Structure Determination

description: Related Article: Hongming Zhang, H.M.Refat, E.Biehl|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1667|doi:10.1107/S0108270195004288
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139k87
title: CCDC 1022078: Experimental Crystal Structure Determination

description: Related Article: D.Cristiano, R.W.Gable, D.A.Lowe, J.Tsanaktsidis|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1658|doi:10.1107/S0108270195002411
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13998z
title: CCDC 1021830: Experimental Crystal Structure Determination

description: Related Article: Hongming Zhang, H.M.Refat, E.Biehl|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1667|doi:10.1107/S0108270195004288
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139qkp
title: CCDC 1022242: Experimental Crystal Structure Determination

description: Related Article: S.Ianelli, M.Nardelli, C.Fraire, G.Grancini, M.Napoletano, F.Santangelo|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1675|doi:10.1107/S0108270195001478
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139qlq
title: CCDC 1022243: Experimental Crystal Structure Determination

description: Related Article: S.Ianelli, M.Nardelli, C.Fraire, G.Grancini, M.Napoletano, F.Santangelo|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1675|doi:10.1107/S0108270195001478
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139qmr
title: CCDC 1022244: Experimental Crystal Structure Determination

description: Related Article: S.Ianelli, M.Nardelli, C.Fraire, G.Grancini, M.Napoletano, F.Santangelo|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1675|doi:10.1107/S0108270195001478
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13993t
title: CCDC 1021825: Experimental Crystal Structure Determination

description: Related Article: A.Linden, S.Stanchev|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1694|doi:10.1107/S0108270195002368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc139sw2
title: CCDC 1022314: Experimental Crystal Structure Determination

description: Related Article: J.Fuller|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1680|doi:10.1107/S0108270195002514
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13991r
title: CCDC 1021823: Experimental Crystal Structure Determination

description: Related Article: A.Linden, S.Stanchev|1995|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|51|1697|doi:10.1107/S0108270195002356
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.