cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12950801.v1
title: Supplementary Material for: Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy

description: <b><i>Background:</i></b> Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV). The impact of DAAs on recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains uncertain. <b><i>Objective:</i></b> We aimed to evaluate the risk of HCC recurrence in LT recipients cleared of HCV with DAAs at the time of LT compared to a control group of LT recipients who were viremic at the time of LT. <b><i>Methods:</i></b> The study was a single-center, retrospective cohort study of patients undergoing LT for HCV-related HCC from 2002 to 2017. We compared time to post-LT HCC recurrence in patients with a sustained virological response (SVR) from DAAs prior to LT (DAA group) to patients who were viremic at LT (HCV+ group) using Kaplan-Meier analysis. We performed a secondary analysis comparing post-LT HCC recurrence in the DAA group to LT recipients with SVR from interferon-based treatment prior to LT (IFN group). <b><i>Results:</i></b> One hundred fifty-one patients underwent LT for HCC related to HCV: 34 patients in DAA group, 95 patients in HCV+ group, and 22 in IFN group. Kaplan-Meier estimates of being HCC free were 96.2, 96.2, and 78.8% at 6, 12, and 24 months in DAA group, respectively, and 100, 98.6, and 95.8% at 6, 12, and 24 months in the HCV+ group, respectively; <i>p</i> = 0.08. There was no difference observed for HCC recurrence between the DAA and IFN groups. In a multivariate Cox proportional hazards model, DAA use increased the risk of post-LT HCC recurrence (HR 5.2, 95% CI 0.9–29.81, <i>p</i> = 0.07). <b><i>Conclusions:</i></b> A strong trend was observed on both Kaplan-Meier and multivariate analyses toward increased post-LT HCC recurrence in patients who achieved SVR prior to LT with DAAs compared to patients who were viremic at LT. Caution is required when considering pre-LT treatment of HCV with DAAs in patients with HCC.
DOI: 10.17632/mrmmv789fm
title: Biosensor versus Modified Early Warning Score for clinical deterioration

description: These three files are necessary to reproduce our research. Every file consists of one sheet. In every sheet, with help of the column 'patient', the data of the files can be merged. Please note that the content of the file 'Sensor data' is so large, that only a csv. file is suitable.
DOI: 10.17632/bwpbmjmnhb
title: Ecological and societal effects of Central Asian streamflow variation over the past eight centuries

description: Understanding changes in water availability is critical for Central Asia, however, long streamflow reconstructions extending beyond the period of instrumental gauge measurements are largely missing. Here, we present a 785-year-long streamflow reconstruction from spruce tree rings from the Tien Shan Mountains. Although an absolute causal relationship can not be established, relatively high streamflow rates coincided roughly with the period of Mongol expansion from 1225–1260 CE and the rise of the Timurid Empire from 1361–1400 CE. Since overall wetter conditions were further found during the Zunghar Khanate period 1693–1705 CE, we argue that phases of streamflow surplus likely promoted oasis and grassland productivity, which was an important factor for the rise of inner Eurasian steppe empires. Moreover, we suggest that the streamflow variation might be critical for plague outbreaks in Central Asia, and propose several explanations for possible links with Europe’s repeated Black Death pandemics. We demonstrate that 20th-century low streamflow is unprecedented in the past eight centuries and exacerbated the Aral Sea crisis, which is one of the most staggering ecological disasters of the twentieth century.
DOI: 10.6084/m9.figshare.19617732.v1
title: Plasma membrane proteins are modulated after vaccinia virus-infection

description: HFFF-TERTs or HeLa cells were mock-treated or infected with VACV at MOI 5 in DMEM supplemented with 2% FCS, 1% P/S. Cells were harvested at 15-18 hpi using accutase solution following the manufacturer’s instructions (Sigma-Aldrich). Validation of PM protein expression was performed with ~2x10^5 cells /sample, stained with Zombie NIR Fixable Viability Kit (Biolegend) in combination with the following antibodies: MHC-I (W6/32, kindly provided by Dr L. Boyle), MICA (2C10, Santa Cruz Biotechnology, Santa Cruz, CA, USA), EPHB4 (rea923, Miltenyi Biotech, Bergisch Gladbach, Germany), FAS(CD95) (DX2, Miltenyi Biotech), EGFR (528, Santa Cruz), HLA-B/C (4E, kindly provided by Dr L. Boyle), HLA-C/E (DT9, kindly provided by Dr L. Boyle), ULBP3 (166510, R&D systems), B7-H6 (875001, R&D systems, Minneapolis, U.S.A), ULBP-2/5/6 (65903, R&D systems), Plexin-B1 (rea728, Miltenyi Biotech), MICB (236511, R&D systems), TNFSRF10D (trail-R4) (104918, R&D systems), CD155 (SKII.4, Santa Cruz), isotype mouse Igg2b (Santa Cruz), isotype mouse IgG2a (Santa Cruz), isotype mouse IgG1 (Santa Cruz). Samples stained with unconjugated primary antibodies were subsequently probed with PE-conjugated Goat anti-mouse IgG (BioLegend). Cells were fixed using Fixation/Permeabilization Solution Kit according to the manufacturer’s instructions (BD Biosciences). Samples were analysed by flow cytometry using an Invitrogen Attune NxT cytometer and FlowJo software.
DOI: 10.17632/82pygctzwn
title: METHODOLOGIES FOR THE EVALUATION AND IMPROVEMENT OF LOADING AND UNLOADING OPERATIONS IN CITY CENTERS

description: ROTATION ANALYSIS In order to understand freight facilities demand in the city center and characterize the operation, rotation counts of freight operations were developed based following on-street parking analysis methodology presented in Cardenas & Cal y Mayor (2007). LEVEL OF SERVICE Loading and unloading performance analysis methodology found in Alho & Silva (2014) was selected as the most appropriate for this context, due to there is a high dependence on bay infrastructure for loading and loading operations and because this methodology was developed in a context of low data availability. STAKEHOLDER ANALYSIS Multi-Actor Multi-Criteria Analysis – MAMCA (Macharis et al., 2010) permitted to conclude that a combined set of strategies for loading and uploading operations in city centers should be implemented to raise parking offer and adapt to different demand conditions in terms of schedules and vehicles sizes. Some strategies requires a strong set of public incentives, including tax benefits and land price controls for logistic use. For this MAMCA analysis the surveys were completed as follows: 10 from Shippers/Carriers, 101 from receivers (Question PRO application used), 6 from authorities, 3 from residents (community leaders) and 2 from academics. According to the Cali Economic Census (DANE, 2006) there are approximately 4222 economic units in Cali city center, of which 23% belong to the retail trading sector for food, drinks and tobacco, the biggest group (CIIU Code 5211 of Chamber of Commerce). We decided to start our research with this type of commerce (971 units) and we have obtained responses from approximately 13% of them, so this represents a statistical confidence level of 90% (Torres, Paz, & Salazar, 2006). We developed 9 questionnaires for the enterprises that can represent approximately the 18% of the total shipper size in Cali city center (Bavaria, Coca-Cola, Productos Cárnicos, Productos Enrico, Distribuidora Colombina, Distribuidora Alpina, Pollos El Galpón, Quesos la Florida, Nutresa). We also interviewed 9 trade leaders and managers of parcel transport companies, (Cavasa, Andi, Adicomex, Sociedad Portuaria, Gids, Posey (International Freight Forwarders), Fedetranscol, Concretesa (Project’s Manager), Fenalco, Grecocentro).
DOI: 10.17632/4ssdn7kmp3
title: Journal of Iran's Economic Essays; "Jostarhaye Eghtesadiye Iran; No. 41

description: The Journal of Iran's Economic Essays; an Islamic approach (IEE) "Jostarhaye Eghtesadiye Iran" is an open-access double-blind peer-reviewed academic semi-annual journal that publishes original research, written with an Islamic approach in various Economic areas including Islamic economics and finance, Iran's economy, Fiqh (Islamic jurisprudence) and economics, philosophy of economics, economic theory, ethics and business, Islamic banking, economic development, and social security institution in Islam. JIEE especially welcomes comparative articles that study the western and Muslim scholars' viewpoints about important economic issues to find the best answer to theoretical and applied questions and also to explore their differences and similarities with the aim of bringing them closer to each other. This journal accepts analytical articles that reread Muslim scholars' ideas according to new approaches in economics, moral philosophy, Islamic banking and finance, social security, econometrics, and Islamic economic institutions. Therefore, it aims to serve the interests of a wide range of thoughtful and academic readers, economists, philosophers, theologians, banking and finance experts and others interested in the multidisciplinary study of economics and Islam (including Fiqh "Islamic jurisprudence"). We hope that this publication creates an atmosphere of constructive dialogue on different economic topics between national and international scholars by which it could have a role in the growth of Islamic economic thought in Iran. In addition, Islamic solutions to the economic problems of Iran and the world will be examined and analyzed, and they will be presented to the policy makers to help improve the Islamic economic system.

Major Topics

 The Journal publishes papers, including the following fields:

- Islamic economics and finance;

 - Iran's economy;

 - Fiqh (Islamic jurisprudence) and economics;

 - Philosophy of economics;

 - Economic theory;

 - Ethics;

- Islamic economic institutions

 - Islamic banking;

 - Economic development;

- Social security.
DOI: 10.21233/mdnh-nr59
title: Kholboo Lake ostracode surface sample dataset

description: Raw data for the Kholboo Lake ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.28856669.v1
title: <b>cefoperazone-sulbactam</b>

description: <b>cefoperazone-sulbactam</b><br>
DOI: 10.6084/m9.figshare.1297738.v4
title: Jisc APC template version 2

description: This template has been designed to be used by UK higher education institutions to record and monitor their article processing charge (APC) payments. It can be used for both internal reporting, and external reporting to RCUK and the Charity Open Access Fund (COAF) for compliance monitoring. Full details are available here: https://www.jisc-collections.ac.uk/Jisc-Monitor/APC-data-collection/ It is recommended that institutions archive the spreadsheets that they release in an online research repository, such as figshare or their own institutional repository. Institutions outside of the UK are welcome to make use of the template as well. If you spot any errors or want to know more, please get in touch at stuart.lawson@jisc.ac.uk
DOI: 10.6084/m9.figshare.7182293.v1
title: Supplementary Material for: Different Genetic Expression Profiles of Oxidative Stress and Apoptosis-Related Genes in Crohn’s Disease

description: <b><i>Background/Aims:</i></b> Increased oxidative stress and decreased immune cell apoptosis have been reported to be important factors in the pathogenesis of Crohn’s disease (CD). Our aim was to characterize the genetic expression of molecules implicated in the regulation of oxidative stress and apoptosis in peripheral white mononuclear cells of 18 healthy volunteers (controls) and 20 patients at the onset of CD (active CD [aCD]): 10 who achieved remission (inactive CD [iCD]) and 10 who did not present a complete and deep response to treatment (aCD-T). <b><i>Methods:</i></b> mRNA expression was measured by the Agena MassARRAY quantitative gene expression analysis application. The genes analyzed were Fas-receptor (FASR), Fas-ligand (FASL), signal transducer and activator of transcription 1 (STAT1), nuclear factor kappa-light-chain-­enhancer of activated B cells (NFKB1), apoptosis signal-regulating kinase 1 (ASK1), serine/threonine-protein kinase H1 (PSKH1), ATP-binding cassette sub-family B1 (ABCB1) and peptidylprolyl isomerase D (PPID). <b><i>Results:</i></b> During a CD flare, we found specific upregulated expression of the genes STAT1 and PSKH1, whereas ABCB1 and FASL were downregulated. In the patients with iCD, FASR and NFKB1 were upregulated. The expression levels of NFKB1, STAT1 and ABCB1 did not show any difference in patients with aCD at the onset of the disease and after treatment (aCD-T). The expression levels of PPID and ASK1 did not show any differences in the patients with aCD, iCD and the controls. We have also reviewed the cellular function and role of these genes in CD. <b><i>Conclusions:</i></b> These findings contribute to improving the understanding of the pathogenesis of CD and highlight potential genes involved.
DOI: 10.17632/r76d3pjnnk
title: Input data and detailed numerical results for 'A biased random-key genetic algorithm for routing and wavelength assignment under a sliding scheduled traffic model in WDM optical networks'

description: Each experiment contains a README file.
DOI: 10.17632/rr6n6sgk56
title: Irisin acts through its integrin receptor in a twp-step process involving extracellular Hsp90α

description: Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with exercise, and conveys physiological benefits, including improved cognition and resistance to neurodegeneration. Irisin acts via αV integrins; however, a mechanistic understanding of how small polypeptides like irisin can signal through integrins is poorly understood. Using mass spectrometry and cryo-EM, we demonstrate that the extracellular heat-shock protein 90α (eHsp90α) is secreted by muscle with exercise and activates integrin αVβ5. This allows for high-affinity irisin binding and signaling through an Hsp90α/αV/β5 complex. By including hydrogen/deuterium exchange data, we generate and experimentally validate a 2.98 Å RMSD irisin/αVβ5 complex docking model. Irisin binds very tightly to an alternative interface on αVβ5 distinct from that used by known ligands. These data elucidate a non-canonical mechanism by which a small polypeptide hormone like irisin can function through an integrin receptor.
DOI: 10.6084/m9.figshare.19195712.v1
title: Supplementary Material for: Effects of Body Weight Change on Development of Chronic Kidney Disease in Obese Metabolic Phenotypes

description: <b><i>Introduction:</i></b> Obesity is a risk factor for chronic kidney disease (CKD), but whether the reduction of body mass index (BMI) helps prevent CKD is controversial. Recently, obese metabolic phenotypes have raised considerable interest. We thus investigated the effect of BMI change on CKD development. <b><i>Methods:</i></b> We analyzed the data of 6,959 subjects who underwent annual health checkups in both 2013 and 2018. The subjects were categorized into five groups according to their BMI percentage change (ΔBMI) and classified into four obese metabolic phenotypes. By a multivariate logistic regression analysis, we investigated the association between BMI change and CKD development within the 5 years. <b><i>Results:</i></b> In total subjects, compared with the maintained BMI group (ΔBMI ≥0% but &lt;2.5%), the odd ratios (ORs) and 95% confidence intervals (CIs) of CKD development were 0.70 (95% CI 0.54–0.91) for the severe BMI decrease group (ΔBMI <i>Conclusions:</i> In the MHO phenotype, an increased BMI deteriorated CKD development, and a decreased BMI ameliorated CKD development in the MUNO phenotype.
DOI: 10.6084/m9.figshare.20025475.v1
title: Predicting financial distress in publicly-traded companies

description: ABSTRACT Several models for forecasting bankruptcy have been developed over the years, one of the reasons for which is the important part it plays in decision-making. However, forecasting a company’s bankruptcy leaves a very short time for stakeholders to change the situation. It is in this context that this paper arises in order to develop a model for predicting financial distress, which is identified as a step prior to bankruptcy. The predictive model uses the logistic regression technique with panel data and a sample of Brazilian publicly-traded companies with shares listed on the São Paulo Stock, Commodities, and Futures Exchange between 2001 and 2014. As well as financial variables, the final model includes market expectations (macroeconomic) and sector variables. These variables are statistically tested and the hypothesis is confirmed that they improve the accuracy of the model. The research identified the existence of financial distress in 96% of the companies that went bankrupt. In addition, the relationship between the phenomena of bankruptcy and financial distress is verified, using financial and macroeconomic explanatory variables. The results demonstrate that most (83%) of the explanatory variables in the model for predicting bankruptcy are also present in the model for predicting the phenomenon of financial distress. The expected gross domestic product variables and the quick ratio, asset turnover, and net equity over total liabilities financial variables are statistically significant in predicting both phenomena. With this evidence, the study suggests the use of the concept of financial distress as a stage prior to bankruptcy and provides a model for predicting financial distress with 89% accuracy when applied to publicly-traded companies in Brazil in the period examined.
DOI: 10.21233/yddf-nf38
title: Khyargas Lake ostracode surface sample dataset

description: Raw data for the Khyargas Lake ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.14472792.v1
title: Supplementary Material for: The Effect of Aging and Small-Vessel Disease Burden on Hematoma Location in Patients with Acute Intracerebral Hemorrhage

description: <b><i>Introduction:</i></b> Intracerebral hemorrhage (ICH) is a devastating hemorrhagic event and is associated with high mortality or severe neurological sequelae. Age-associated differences in hematoma location for nonlobar ICH are not well known. The aims of the present study were to elucidate the relationship between age and hematoma location and to assess the differences in small-vessel disease (SVD) burden as a potential surrogate marker for longstanding hypertension among various hematoma locations. <b><i>Methods:</i></b> From September 2014 through July 2019, consecutive patients with acute, spontaneous ICH were retrospectively enrolled from a prospective registry. Magnetic resonance imaging was performed during admission, and the total SVD burden score (including microbleeds, lacunes, enlarged perivascular spaces, and white matter hyperintensities) was calculated. The relationships of hematoma location with aging and SVD burden were assessed by using multivariate logistic regression analyses. <b><i>Results:</i></b> A total of 444 patients (156 women [35%]; median age 69 [interquartile range 59–79] years; National Institutes of Health Stroke Scale score 9 [17][3–17]) were enrolled in the present study. Multivariate logistic regression analyses showed that advanced age was independently associated with thalamic (odds ratio [OR]: 1.48, 95% confidence interval [CI]: 1.19–1.84, <i>p</i> &lt; 0.001 for 10-year increment) and lobar hemorrhage (OR: 1.58, 95% CI: 1.19–2.09, <i>p</i> = 0.002) and was independently and negatively related to putaminal hemorrhage (OR: 0.55, 95% CI: 0.44–0.68, <i>p</i> &lt; 0.001). The total SVD burden score was independently and positively associated with thalamic hemorrhage (OR: 1.27, 95% CI: 1.01–1.59, <i>p</i> = 0.045) and negatively with lobar hemorrhage (OR: 0.74, 95% CI: 0.55–0.99, <i>p</i> = 0.042), even after adjusting by age, but not with putaminal hemorrhage (OR: 0.91, 95% CI: 0.73–1.14, <i>p</i> = 0.395). <b><i>Conclusion:</i></b> Putaminal, thalamic, and lobar hemorrhages are prone to occur in specific ages and SVD states: putaminal in young patients, thalamic in old and high SVD burden patients, and lobar hemorrhages in old and low SVD burden patients. Susceptibility to bleeding with aging or severe SVD accumulation seems to differ considerably among brain locations.
DOI: 10.17632/jw25y27vrm
title: Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Fernandez-Castaneda et al

description: Source data and supplemental tables.
DOI: 10.17632/pbm89t98xg
title: Aluminum Life Cycle Inventory Dataset for China

description: This dataset has been established to address the lack of a comprehensive lifecycle inventory dataset for China's aluminum industry, a sector of critical importance due to its environmental and economic implications. It comprises 38 data sources, 216 processes and 2193 flows of China’s aluminum industry. The data collection process was rigorously conducted, adhering to the rules of data traceability and transparency. This dataset contributes significantly to the aluminum sector in China, enhancing the accuracy of LCA studies and supporting more informed and sustainable decisions.
DOI: 10.17632/xkj9czhpth
title: Conjunto de datos del asesoramiento en el diagnóstico institucional del estado de las Competencias Digitales Docente: Caso de la Unidad Educativa del Milenio Amazonas, período académico 2020 - 2021

description: In an environment mediated by Information and Communication Technologies due to the pandemic (COVID-19), it is necessary the Educational Counselling (EC) in the institutional diagnosis of the professional training needs (D1.C2.GE4) of the Teaching Digital Competences (TDC). Considering that the Amazonas Millennium Educational Unit did not have this diagnosis, the question was posed: to what extent will the counselling of the institutional diagnosis serve to determine the status of the TDC? Within the framework of the Educational Quality Standards, the objective was to counsel the Director in this diagnosis through the Counselling Plan for the determination of the state of the TDC, academic period 2020 - 2021. The study was mixed of explanatory scope and used Action Research, where the Director was the subject of the study. Information gathering techniques such as official documents, interview and Delphi were applied; likewise, analysis techniques such as content analysis and descriptive statistics were used. The results indicated weaknesses and strengths of the School Management at the time of this diagnosis, which was the basis for proposing a Plan, submitted to the judgment and validation of experts. The implementation of the Plan indicated that the stages and methodology of counselling guide the institutional management in a strategic, truthful, pertinent, and sufficient manner. Therefore, it is concluded that the counselling of the institutional diagnosis allows the determination of the state of the TDC, thus favoring the creation of knowledge through the EC process.