cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1304573.v2
title: Out-of-Position Rear Impact Tissue-Level Investigation Using Detailed Finite Element Neck Model

description: <b>Objective:</b> Whiplash injuries can occur in automotive crashes and may cause long-term health issues such as neck pain, headache, and visual and auditory disturbance. Evidence suggests that nonneutral head posture can significantly increase the potential for injury in a given impact scenario, but epidemiological and experimental data are limited and do not provide a quantitative assessment of the increased potential for injury. Although there have been some attempts to evaluate this important issue using finite element models, none to date have successfully addressed this complex problem.<b>Methods:</b> An existing detailed finite element neck model was evaluated in nonneutral positions and limitations were identified, including musculature implementation and attachment, upper cervical spine kinematics in axial rotation, prediction of ligament failure, and the need for repositioning the model while incorporating initial tissue strains. The model was enhanced to address these issues and an iterative procedure was used to determine the upper cervical spine ligament laxities. The neck model was revalidated using neutral position impacts and compared to an out-of-position cadaver experiment in the literature. The effects of nonneutral position (axial head rotation) coupled with muscle activation were studied at varying impact levels.<b>Results:</b> The laxities for the ligaments of the upper cervical spine were determined using 4 load cases and resulted in improved response and predicted failure loads relative to experimental data. The predicted head response from the model was similar to an experimental head-turned bench-top rear impact experiment. The parametric study identified specific ligaments with increased distractions due to an initial head-turned posture and the effect of active musculature leading to reduced ligament distractions.<b>Conclusions:</b> The incorporation of ligament laxity in the upper cervical spine was essential to predict range of motion and traumatic response, particularly for repositioning of the neck model prior to impact. The results of this study identify a higher potential for injury in out-of-position rear collisions and identified at-risk locations based on ligament distractions. The model predicted higher potential for injury by as much as 50% based on ligament distraction for the out-of-position posture and reduced potential for injury with muscle activation. Importantly, this study demonstrated that the location of injury or pain depends on the initial occupant posture, so that both the location of injury and kinematic threshold may vary when considering common head positions while driving.
DOI: 10.6084/m9.figshare.1304540.v1
title: 25_T_T

description: Archive with graphs.
DOI: 10.6084/m9.figshare.1304541.v1
title: 25_T_F

description: Archive with graphs.
DOI: 10.6084/m9.figshare.1304535
title: A structured review of quantitative models in the blood supply chain: a taxonomic framework for decision-making

description: This paper presents a structured review of the literature on quantitative modelling for the blood product supply chain. This is a widely researched topic, dating back to the 1960s, and several other reviews have been published over the years. However, this paper presents new relevant information for researchers, not only by including more recent models but chiefly because of the structured way in which the models are presented. The models are broken down into five categories. The first four categories represent the four stages (echelons) in the supply chain: collection, production, inventory and delivery. The final category contains ‘integrated’ models which cover more than one stage. Each section (other than integrated models, which are treated slightly differently) contains two distinct elements. The first element is a diagrammatic representation of decisions and relationships, broken down by hierarchy level (strategic – tactical – operational). The second element is a text description of the main features, contributions and gaps found in the analysed models. An additional element for each section is available online, namely a searchable table describing specific features of each echelon, together with a taxonomic key to assist the reader.
DOI: 10.6084/m9.figshare.1304534
title: Supplementary Materials _Part A_Haili Lin

description: Supplementary Materials for Part A progress report
DOI: 10.6084/m9.figshare.1304535.v1
title: A structured review of quantitative models in the blood supply chain: a taxonomic framework for decision-making

description: This paper presents a structured review of the literature on quantitative modelling for the blood product supply chain. This is a widely researched topic, dating back to the 1960s, and several other reviews have been published over the years. However, this paper presents new relevant information for researchers, not only by including more recent models but chiefly because of the structured way in which the models are presented. The models are broken down into five categories. The first four categories represent the four stages (echelons) in the supply chain: collection, production, inventory and delivery. The final category contains ‘integrated’ models which cover more than one stage. Each section (other than integrated models, which are treated slightly differently) contains two distinct elements. The first element is a diagrammatic representation of decisions and relationships, broken down by hierarchy level (strategic – tactical – operational). The second element is a text description of the main features, contributions and gaps found in the analysed models. An additional element for each section is available online, namely a searchable table describing specific features of each echelon, together with a taxonomic key to assist the reader.
DOI: 10.6084/m9.figshare.1304528
title: LST MODIS

description: Land Surface Temperature over the Amazon forest. Data extracted from MODIS products.
DOI: 10.6084/m9.figshare.1304526
title: LCOVER MODIS

description: MODIS Land Cover product over the Amazon forest
DOI: 10.6084/m9.figshare.1304534.v2
title: Supplementary Materials _Part A_Haili Lin

description: Supplementary Materials for Part A progress report
DOI: 10.6084/m9.figshare.1304523
title: Bangladesh Interruption of Secondary Transmission of Influenza (BISTIS)

description: These are deidentified data from the Bangladesh Interruption of Secondary Transmission of Influenza Study (BISTIS), a randomized controlled trial conducted in Kishoregonj, Bangladesh, to investigate the effects of intensive handwashing promotion on transmission of influenza and influenza-like illness among household members.
DOI: 10.6084/m9.figshare.1304526.v1
title: LCOVER MODIS

description: MODIS Land Cover product over the Amazon forest
DOI: 10.6084/m9.figshare.1304534.v1
title: Supplementary Materials _Part A_Haili Lin

description: Supplementary Materials for Part A progress report
DOI: 10.6084/m9.figshare.1304519
title: Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

description: Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
DOI: 10.6084/m9.figshare.1304520
title: Supplementary Information Table S1

description: This is a supplementary information table of paper "Influence of fire on the vegetative phenological behavior of Brazilian savanna woody species" published in the scientific journal Biota Neotropica (http://www.biotaneotropica.org.br/).
DOI: 10.6084/m9.figshare.1304505
title: Genes co-regulated with <i>LBD16</i> in nematode feeding sites inferred from <i>in silico</i> analysis show similarities to regulatory circuits mediated by the auxin/cytokinin balance in Arabidopsis

description: Plant endoparasitic nematodes, root-knot and cyst nematodes (RKNs and CNs) induce within the root vascular cylinder transfer cells used for nourishing, termed giant cells (GCs) and syncytia. Understanding the molecular mechanisms behind this process is essential to develop tools for nematode control. Based on the crucial role in gall development of <i>LBD16</i>, also a key component of the auxin pathway leading to the divisions in the xylem pole pericycle during lateral root (LR) formation, we investigated genes co-regulated with <i>LBD16</i> in different transcriptomes and analyzed their similarities and differences with those of RKNs and CNs feeding sites (FS). This analysis confirmed <i>LBD16</i> and its co-regulated genes, integrated in signaling cascades mediated by auxins during LR and callus formation, as a particular feature of RKN-FS distinct to CNs. However, <i>LBD16</i>, and its positively co-regulated genes, were repressed in syncytia, suggesting a selective down- regulation of the <i>LBD16</i> auxin mediated pathways in CNs-FS. Interestingly, cytokinin-induced genes are enriched in syncytia and we encountered similarities between the transcriptome of shoot regeneration from callus, modulated by cytokinins, and that of syncytia. These findings establish differences in the regulatory networks leading to both FS formation, probably modulated by the auxin/cytokinin balance.
DOI: 10.6084/m9.figshare.1304519.v1
title: Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis.

description: Two pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
DOI: 10.6084/m9.figshare.1304519.v2
title: Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

description: Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
DOI: 10.6084/m9.figshare.1304479.v1
title: Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes

description: Phylogenetic trees from the paper "Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes" by Crisp et al. published in Genome Biology
DOI: 10.6084/m9.figshare.1304505.v1
title: Genes co-regulated with <i>LBD16</i> in nematode feeding sites inferred from <i>in silico</i> analysis show similarities to regulatory circuits mediated by the auxin/cytokinin balance in Arabidopsis

description: Plant endoparasitic nematodes, root-knot and cyst nematodes (RKNs and CNs) induce within the root vascular cylinder transfer cells used for nourishing, termed giant cells (GCs) and syncytia. Understanding the molecular mechanisms behind this process is essential to develop tools for nematode control. Based on the crucial role in gall development of <i>LBD16</i>, also a key component of the auxin pathway leading to the divisions in the xylem pole pericycle during lateral root (LR) formation, we investigated genes co-regulated with <i>LBD16</i> in different transcriptomes and analyzed their similarities and differences with those of RKNs and CNs feeding sites (FS). This analysis confirmed <i>LBD16</i> and its co-regulated genes, integrated in signaling cascades mediated by auxins during LR and callus formation, as a particular feature of RKN-FS distinct to CNs. However, <i>LBD16</i>, and its positively co-regulated genes, were repressed in syncytia, suggesting a selective down- regulation of the <i>LBD16</i> auxin mediated pathways in CNs-FS. Interestingly, cytokinin-induced genes are enriched in syncytia and we encountered similarities between the transcriptome of shoot regeneration from callus, modulated by cytokinins, and that of syncytia. These findings establish differences in the regulatory networks leading to both FS formation, probably modulated by the auxin/cytokinin balance.
DOI: 10.6084/m9.figshare.1304445
title: WOMEN AND HEALTH IN INDIA: AN OVERVIEW

description: Women constituting around half of the population play a distinct role in the development of our nation. As a mother, she shapes the personality and character of her children and thereby the character of the nation. As a housewife, she maintains the productivity of the human capital within her household through proper home management. Apart from this, a woman herself represents a unit of human capital and is therefore capable of contributing to the economy of the nation. Thus, unless women are mobilized towards contributing to the national development and growth, the nation is only half way towards development.
DOI: 10.6084/m9.figshare.1304519.v3
title: Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

description: Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
DOI: 10.6084/m9.figshare.1304445.v1
title: WOMEN AND HEALTH IN INDIA: AN OVERVIEW

description: Women constituting around half of the population play a distinct role in the development of our nation. As a mother, she shapes the personality and character of her children and thereby the character of the nation. As a housewife, she maintains the productivity of the human capital within her household through proper home management. Apart from this, a woman herself represents a unit of human capital and is therefore capable of contributing to the economy of the nation. Thus, unless women are mobilized towards contributing to the national development and growth, the nation is only half way towards development.
DOI: 10.6084/m9.figshare.1304519.v5
title: Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

description: Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
DOI: 10.6084/m9.figshare.1304505.v2
title: Genes co-regulated with <i>LBD16</i> in nematode feeding sites inferred from <i>in silico</i> analysis show similarities to regulatory circuits mediated by the auxin/cytokinin balance in Arabidopsis

description: Plant endoparasitic nematodes, root-knot and cyst nematodes (RKNs and CNs) induce within the root vascular cylinder transfer cells used for nourishing, termed giant cells (GCs) and syncytia. Understanding the molecular mechanisms behind this process is essential to develop tools for nematode control. Based on the crucial role in gall development of <i>LBD16</i>, also a key component of the auxin pathway leading to the divisions in the xylem pole pericycle during lateral root (LR) formation, we investigated genes co-regulated with <i>LBD16</i> in different transcriptomes and analyzed their similarities and differences with those of RKNs and CNs feeding sites (FS). This analysis confirmed <i>LBD16</i> and its co-regulated genes, integrated in signaling cascades mediated by auxins during LR and callus formation, as a particular feature of RKN-FS distinct to CNs. However, <i>LBD16</i>, and its positively co-regulated genes, were repressed in syncytia, suggesting a selective down- regulation of the <i>LBD16</i> auxin mediated pathways in CNs-FS. Interestingly, cytokinin-induced genes are enriched in syncytia and we encountered similarities between the transcriptome of shoot regeneration from callus, modulated by cytokinins, and that of syncytia. These findings establish differences in the regulatory networks leading to both FS formation, probably modulated by the auxin/cytokinin balance.
DOI: 10.6084/m9.figshare.1304519.v4
title: Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

description: Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process.
DOI: 10.6084/m9.figshare.1304397
title: Gaussian Job Archive for C19H18N2O3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1304505.v3
title: Genes co-regulated with <i>LBD16</i> in nematode feeding sites inferred from <i>in silico</i> analysis show similarities to regulatory circuits mediated by the auxin/cytokinin balance in Arabidopsis

description: Plant endoparasitic nematodes, root-knot and cyst nematodes (RKNs and CNs) induce within the root vascular cylinder transfer cells used for nourishing, termed giant cells (GCs) and syncytia. Understanding the molecular mechanisms behind this process is essential to develop tools for nematode control. Based on the crucial role in gall development of <i>LBD16</i>, also a key component of the auxin pathway leading to the divisions in the xylem pole pericycle during lateral root (LR) formation, we investigated genes co-regulated with <i>LBD16</i> in different transcriptomes and analyzed their similarities and differences with those of RKNs and CNs feeding sites (FS). This analysis confirmed <i>LBD16</i> and its co-regulated genes, integrated in signaling cascades mediated by auxins during LR and callus formation, as a particular feature of RKN-FS distinct to CNs. However, <i>LBD16</i>, and its positively co-regulated genes, were repressed in syncytia, suggesting a selective down- regulation of the <i>LBD16</i> auxin mediated pathways in CNs-FS. Interestingly, cytokinin-induced genes are enriched in syncytia and we encountered similarities between the transcriptome of shoot regeneration from callus, modulated by cytokinins, and that of syncytia. These findings establish differences in the regulatory networks leading to both FS formation, probably modulated by the auxin/cytokinin balance.
DOI: 10.6084/m9.figshare.1304350
title: Data Inter-training interval

description: These data show the results of four tests, one pretest and three posttest. It consist of three variables. Each task is performed three times (three trials). The movement times, the time it took to perform three different functional tasks. The duration of the maximal handopening during one of these tasks. And the deviation of the grip force control, in a task where a handle needed to be grasped with the correct amount of force.
DOI: 10.6084/m9.figshare.1304392
title: Online Data Supplement: Longevity is linked to mitochondrial mutation rates in rockfish: a test using Poisson regression

description: This is the online supplement for: Xia Hua, Peter Cowman, Dan Warren, and Lindell Bromham <em>Longevity is linked to mitochondrial mutation rates in rockfish: a test using Poisson regression.</em> Mol Biol Evol first published online June 5, 2015 doi:10.1093/molbev/msv137 It contains scripts, files and alignments assoicated with the paper to reproduce the branch length estimation analyses
DOI: 10.6084/m9.figshare.1304397.v1
title: Gaussian Job Archive for C19H18N2O3

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.