cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10218427
title: Data underpinning "Noncoplanar magnetic order in classical square-kagome antiferromagnets"

description: Motivated by the recent synthesis of a number of Mott insulating square-kagome materials, we explore the rich phenomenology of frustrated magnetism induced by this lattice geometry, also referred to as the squagome or shuriken lattice. On the classical level, square-kagome antiferromagnets are found to exhibit extensive degeneracies, order-by-disorder, and non-coplanar ordering tendencies, which we discuss for an elementary, classical Heisenberg model with nearest-neighbor and cross-plaquette interactions. Having in mind that upon introducing quantum fluctuations non-coplanar order can melt into chiral quantum spin liquids, we provide detailed information on the multitude of non-coplanar orders, including some which break rotational symmetry (possibly leading to nematic quantum orders), as well as a number of (incommensurate) spin spiral phases. Using extensive numerical simulations, we also discuss the thermodynamic signatures of these phases, which often show multi-step thermal ordering. Our comprehensive discussion of the classical square-kagome Heisenberg model, often drawing comparisons to the conventional kagome antiferromagnet, sets the stage for future explorations of quantum analogs of the various phases, either conceptually such as in quantum spin-1/2 generalizations of our model or experimentally such as in the Cu-based candidate materials.
DOI: 10.5281/zenodo.10218426
title: Data underpinning "Noncoplanar magnetic order in classical square-kagome antiferromagnets"

description: Motivated by the recent synthesis of a number of Mott insulating square-kagome materials, we explore the rich phenomenology of frustrated magnetism induced by this lattice geometry, also referred to as the squagome or shuriken lattice. On the classical level, square-kagome antiferromagnets are found to exhibit extensive degeneracies, order-by-disorder, and non-coplanar ordering tendencies, which we discuss for an elementary, classical Heisenberg model with nearest-neighbor and cross-plaquette interactions. Having in mind that upon introducing quantum fluctuations non-coplanar order can melt into chiral quantum spin liquids, we provide detailed information on the multitude of non-coplanar orders, including some which break rotational symmetry (possibly leading to nematic quantum orders), as well as a number of (incommensurate) spin spiral phases. Using extensive numerical simulations, we also discuss the thermodynamic signatures of these phases, which often show multi-step thermal ordering. Our comprehensive discussion of the classical square-kagome Heisenberg model, often drawing comparisons to the conventional kagome antiferromagnet, sets the stage for future explorations of quantum analogs of the various phases, either conceptually such as in quantum spin-1/2 generalizations of our model or experimentally such as in the Cu-based candidate materials.
DOI: 10.5517/ccdc.csd.cc2hkn91
title: CCDC 2310873: Experimental Crystal Structure Determination

description: Related Article: Kevin Schwitalla, Marc Schmidtmann, Rüdiger Beckhaus|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hknb2
title: CCDC 2310874: Experimental Crystal Structure Determination

description: Related Article: Kevin Schwitalla, Marc Schmidtmann, Rüdiger Beckhaus|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.24657846
title: Full_List_of_Dynamic_Cluster_ABCD

description: As PRC2 shows preference for binding to unmethylated CG-rich sequences in mammals, we asked whether the observed H3K27me3 remodelling is due to recruitment of PRC2 in response to global DNA demethylation.To understand the potential relationship, we categorized promoters based on the changes in DNA methylation and H3K27me3 between E10.5 and E13.5 (see Methods). We observed four patterns: Group A, loss of 5mC, gain of H3K27me3; Group B, loss of 5mC, continuous H3K27me3 enrichment; Group C, devoid of 5mC, continuous high level of H3K27me3; Group D, loss of 5mC, devoid of H3K27me3.Sex-specific chromatin remodelling safeguards transcription in germ cellsPMID: <b>34880491</b>DOI: 10.1038/s41586-021-04208-5
DOI: 10.6084/m9.figshare.24657846.v1
title: Full_List_of_Dynamic_Cluster_ABCD

description: As PRC2 shows preference for binding to unmethylated CG-rich sequences in mammals, we asked whether the observed H3K27me3 remodelling is due to recruitment of PRC2 in response to global DNA demethylation.To understand the potential relationship, we categorized promoters based on the changes in DNA methylation and H3K27me3 between E10.5 and E13.5 (see Methods). We observed four patterns: Group A, loss of 5mC, gain of H3K27me3; Group B, loss of 5mC, continuous H3K27me3 enrichment; Group C, devoid of 5mC, continuous high level of H3K27me3; Group D, loss of 5mC, devoid of H3K27me3.Sex-specific chromatin remodelling safeguards transcription in germ cellsPMID: <b>34880491</b>DOI: 10.1038/s41586-021-04208-5
DOI: 10.6084/m9.figshare.24466945.v1
title: Supplementary Material for: Brain Injury Outcomes after Adjuvant Erythropoietin Neuroprotection for Moderate or Severe Neonatal Hypoxic-Ischemic Encephalopathy: A Report from the HEAL Trial

description: Introduction. Erythropoietin (Epo) is a putative neuroprotective therapy that did not improve overall outcomes in a phase 3 randomized controlled trial for neonates with moderate or severe hypoxic-ischemic encephalopathy (HIE). However, HIE is a heterogeneous disorder, and it remains to be determined whether Epo had beneficial effects on a subset of perinatal brain injuries. Methods. This study was a secondary analysis of neuroimaging data from the High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial, which was conducted from 2016 – 2021 at 17 sites involving 23 US academic medical centers. Participants were neonates &gt;36 weeks’ gestation undergoing therapeutic hypothermia for moderate or severe HIE who received 5 doses of study drug (Epoetin alpha 1000 U/kg/dose) or placebo in the first week of life. Treatment assignment was stratified by trial site and severity of encephalopathy. The primary outcome was the locus, pattern and acuity of brain injury as determined by three independent readers using a validated HIE Magnetic Resonance Imaging (MRI) scoring system. Results. Of the 500 infants enrolled in HEAL, 470 (94%) had high quality MRI data obtained at a median of 4.9 days of age (IQR 4.5 – 5.8). The incidence of injury to the deep grey nuclei, cortex, white matter, brainstem and cerebellum was similar between Epo and placebo groups. Likewise, the distribution of injury patterns was similar between groups. Among infants imaged at less than 8 days (n=414), 94 (23%) evidenced only acute, 93 (22%) only subacute and 89 (21%) both acute and subacute injuries, with similar distribution across treatment groups. Conclusion. Adjuvant erythropoietin did not reduce the incidence of regional brain injury. Subacute brain injury was more common than previously reported, which has key implications for the development of adjuvant neuroprotective therapies for this population.
DOI: 10.6084/m9.figshare.24482113
title: Supplementary Material for: Efficacy of the Cytokine Adsorption Therapy in Patients with Severe COVID-19-Associated Pneumonia: Lesson Learned from a Prospective Observational Study

description: Introduction: Severe COVID-19 pneumonia can activate a cytokine storm. Hemoperfusion can reduce pro-inflammatory cytokines in sepsis but is still debated in the COVID-19 setting. Thus, we sought to investigate the benefits of HA-330 cytokine adsorption through clinical and laboratory outcomes. Methods: We conducted a single-center prospective observational study in adults with severe COVID-19 pneumonia admitted to the intensive care unit (ICU) at Chiang Mai University Hospital (Chiang Mai, Thailand). Those with cytokine storms indicated by organ injury, including acute respiratory distress syndrome (ARDS), and high inflammatory markers were included. Patients treated with the HA-330 device were classified as a hemoperfusion group, while those without cytokine adsorption were classified as a control group. We compared the outcomes on day 7 after treatment and evaluated the factors associated with 60-day mortality. Results: A total of 112 patients were enrolled. Thirty-eight patients received hemoperfusion, while 74 patients did not. Baseline cytokine storm parameters were comparable. In univariate analysis, there was an improvement in clinical and laboratory effects from hemoperfusion therapy. In multivariate analysis, APACHE II score, SOFA score, PaO2/FiO2, the number of hemoperfusion sessions, the amount of blood purified, hs-CRP, and IL-6 were associated with mortality. Using at least 3 sessions of hemoperfusion could mitigate the 60-day mortality (adjusted odds ratio 0.25, 95% CI 0.03-0.33, p=0.001). By categorizing the amount of blood treated into 3 groups of &lt;1 L/kg, 1-2 L/kg, and ≥2 L/kg, there was a linear dose-response association with survival, which was better in the higher volume purified (mortality 60% vs 33.3% vs 0%, respectively, p=0.015). Conclusions: The early initiation of HA-330 hemoperfusion could improve the severity score and laboratory outcomes of COVID-19 ARDS. The optimal dose of at least three sessions or the amount of blood purified greater than 1 L/kg were associated with a reduction in 60-day mortality.
DOI: 10.6084/m9.figshare.24482113.v1
title: Supplementary Material for: Efficacy of the Cytokine Adsorption Therapy in Patients with Severe COVID-19-Associated Pneumonia: Lesson Learned from a Prospective Observational Study

description: Introduction: Severe COVID-19 pneumonia can activate a cytokine storm. Hemoperfusion can reduce pro-inflammatory cytokines in sepsis but is still debated in the COVID-19 setting. Thus, we sought to investigate the benefits of HA-330 cytokine adsorption through clinical and laboratory outcomes. Methods: We conducted a single-center prospective observational study in adults with severe COVID-19 pneumonia admitted to the intensive care unit (ICU) at Chiang Mai University Hospital (Chiang Mai, Thailand). Those with cytokine storms indicated by organ injury, including acute respiratory distress syndrome (ARDS), and high inflammatory markers were included. Patients treated with the HA-330 device were classified as a hemoperfusion group, while those without cytokine adsorption were classified as a control group. We compared the outcomes on day 7 after treatment and evaluated the factors associated with 60-day mortality. Results: A total of 112 patients were enrolled. Thirty-eight patients received hemoperfusion, while 74 patients did not. Baseline cytokine storm parameters were comparable. In univariate analysis, there was an improvement in clinical and laboratory effects from hemoperfusion therapy. In multivariate analysis, APACHE II score, SOFA score, PaO2/FiO2, the number of hemoperfusion sessions, the amount of blood purified, hs-CRP, and IL-6 were associated with mortality. Using at least 3 sessions of hemoperfusion could mitigate the 60-day mortality (adjusted odds ratio 0.25, 95% CI 0.03-0.33, p=0.001). By categorizing the amount of blood treated into 3 groups of &lt;1 L/kg, 1-2 L/kg, and ≥2 L/kg, there was a linear dose-response association with survival, which was better in the higher volume purified (mortality 60% vs 33.3% vs 0%, respectively, p=0.015). Conclusions: The early initiation of HA-330 hemoperfusion could improve the severity score and laboratory outcomes of COVID-19 ARDS. The optimal dose of at least three sessions or the amount of blood purified greater than 1 L/kg were associated with a reduction in 60-day mortality.
DOI: 10.5281/zenodo.7142721
title: A seasonal analysis of aerosol NO3- sources and NOx oxidation pathways in the Southern Ocean marine boundary layer

description: This dataset includes coarse mode atmopsheric nitrate concentration and isotopic composition from the Southern Ocean marine boundary layer in summer (2018/19), winter (2019) and spring (2019). Environmental data (temperature, SLP and relative humidity) are also included.
DOI: 10.5281/zenodo.7142722
title: A seasonal analysis of aerosol NO3- sources and NOx oxidation pathways in the Southern Ocean marine boundary layer

description: This dataset includes coarse mode atmopsheric nitrate concentration and isotopic composition from the Southern Ocean marine boundary layer in summer (2018/19), winter (2019) and spring (2019). Environmental data (temperature, SLP and relative humidity) are also included.
DOI: 10.5281/zenodo.5740618
title: The importance of alkyl nitrates and sea ice emissions to atmospheric NOx sources and cycling in the summertime Southern Ocean marine boundary layer.

description: This data set includes atmospheric nitrate concentrations (corrected), nitrogen and oxygen isotopic compositions of atmospheric nitrate, wind speeds, atmospheric temperature, relative humidity and sea surface nitrite concentrations.
DOI: 10.48579/pro/gzq9fn/fhxqyi
title: BD_Dde_Pph.tab

description: :unav
DOI: 10.4121/84e7ddd5-e623-41d0-885d-d69a67907d54
title: Dataset to Examine the Vulnerability Counts and Patching Behavior of 104 IoT Vendors

description: This dataset aims to analyze persistent issues in IoT security, focusing on vendor responsibility. We investigate whether IoT-centric vendors perform worse than industry counterparts. Analyzing NVD data (30,056 CVEs) for 104 IoT vendors from January 2016 to November 2022, we consider factors like vendor size, location, and vulnerability disclosure policy. Our analysis reveals that IoT-centric vendors tend to produce more vulnerabilities.<br>Examining patching behavior, we collect unique data on the availability and timeliness of patches for 2,741 vulnerabilities (both IoT and non-IoT) from 104 leading vendors. Surprisingly, IoT-centric vendors are not worse; they release more patches on time compared to non-IoT-centric vendors. This dataset deepens understanding of IoT security factors and offers empirical insights for regulatory interventions to enhance IoT vendor security performance.<br><br><br><br><br>
DOI: 10.4121/84e7ddd5-e623-41d0-885d-d69a67907d54.v1
title: Dataset to Examine the Vulnerability Counts and Patching Behavior of 104 IoT Vendors

description: This dataset aims to analyze persistent issues in IoT security, focusing on vendor responsibility. We investigate whether IoT-centric vendors perform worse than industry counterparts. Analyzing NVD data (30,056 CVEs) for 104 IoT vendors from January 2016 to November 2022, we consider factors like vendor size, location, and vulnerability disclosure policy. Our analysis reveals that IoT-centric vendors tend to produce more vulnerabilities.<br>Examining patching behavior, we collect unique data on the availability and timeliness of patches for 2,741 vulnerabilities (both IoT and non-IoT) from 104 leading vendors. Surprisingly, IoT-centric vendors are not worse; they release more patches on time compared to non-IoT-centric vendors. This dataset deepens understanding of IoT security factors and offers empirical insights for regulatory interventions to enhance IoT vendor security performance.<br><br><br><br><br>
DOI: 10.6084/m9.figshare.24658050
title: HEK293 R-loop peaks

description: The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks were merged, resized to 500 bp and non-mappable regions and regions of the ENCODE blacklist were discarded.
DOI: 10.6084/m9.figshare.24658050.v1
title: HEK293 R-loop peaks

description: The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks were merged, resized to 500 bp and non-mappable regions and regions of the ENCODE blacklist were discarded.
DOI: 10.6084/m9.figshare.24658080
title: K562 R-loop peaks

description: The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks were merged, resized to 500 bp and non-mappable regions and regions of the ENCODE blacklist were discarded.
DOI: 10.6084/m9.figshare.24658080.v1
title: K562 R-loop peaks

description: The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks were merged, resized to 500 bp and non-mappable regions and regions of the ENCODE blacklist were discarded.
DOI: 10.6084/m9.figshare.22723835
title: Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway

description: Background and objective: Epidemiological research have displayed that dietary intake rich in lycopene, an antioxidant, is negatively correlated with the risk of cardiovascular disease (CVD). This study aimed to investigate whether the intervention with different concentrations of lycopene could attenuate H<sub>2</sub>O<sub>2</sub>-induced oxidative stress injury in human vascular endothelial cells (VECs). Methods: The human VECs HMEC-1 and ECV-304 were incubated with a final concentration of 300 µmol/L H<sub>2</sub>O<sub>2</sub>, followed by they were incubated with lycopene at doses of 0.5, 1, or 2 µm. Subsequently, cell proliferation, cytotoxicity, cell adhesion, reactive oxygen species (ROS) contents, adhesion molecule expression, oxidative stress levels, pro-inflammatory factor production, the apoptosis protein levels, and the silent information regulator-1 (SIRT1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway protein levels were tested by CCK-8 kit, lactate dehydrogenase (LDH) kit, immunofluorescence labeling, cell surface enzyme immunoassays (EIA), enzyme-linked immunosorbent assay (ELISA), as well as Western blot assays, respectively. Results: Under H<sub>2</sub>O<sub>2</sub> stimulation, HMEC-1 and ECV-304 cell proliferation and the SIRT1/Nrf2/HO-1 pathway protein expression were significantly reduced, whereas cytotoxicity, apoptosis, cell adhesion molecule expression, pro-inflammatory and oxidative stress factors production were apparently encouraged, which were partially countered by lycopene intervention in a dose-dependent manner. Conclusion: Lycopene alleviates H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in human VECs by reducing intracellular ROS levels, inflammatory factor production, cell adhesiveness, and apoptosis rate under oxidative stress conditions through activation of the SIRT1/Nrf2/HO-1 pathway.
DOI: 10.6084/m9.figshare.22723835.v1
title: Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway

description: Background and objective: Epidemiological research have displayed that dietary intake rich in lycopene, an antioxidant, is negatively correlated with the risk of cardiovascular disease (CVD). This study aimed to investigate whether the intervention with different concentrations of lycopene could attenuate H<sub>2</sub>O<sub>2</sub>-induced oxidative stress injury in human vascular endothelial cells (VECs). Methods: The human VECs HMEC-1 and ECV-304 were incubated with a final concentration of 300 µmol/L H<sub>2</sub>O<sub>2</sub>, followed by they were incubated with lycopene at doses of 0.5, 1, or 2 µm. Subsequently, cell proliferation, cytotoxicity, cell adhesion, reactive oxygen species (ROS) contents, adhesion molecule expression, oxidative stress levels, pro-inflammatory factor production, the apoptosis protein levels, and the silent information regulator-1 (SIRT1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway protein levels were tested by CCK-8 kit, lactate dehydrogenase (LDH) kit, immunofluorescence labeling, cell surface enzyme immunoassays (EIA), enzyme-linked immunosorbent assay (ELISA), as well as Western blot assays, respectively. Results: Under H<sub>2</sub>O<sub>2</sub> stimulation, HMEC-1 and ECV-304 cell proliferation and the SIRT1/Nrf2/HO-1 pathway protein expression were significantly reduced, whereas cytotoxicity, apoptosis, cell adhesion molecule expression, pro-inflammatory and oxidative stress factors production were apparently encouraged, which were partially countered by lycopene intervention in a dose-dependent manner. Conclusion: Lycopene alleviates H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in human VECs by reducing intracellular ROS levels, inflammatory factor production, cell adhesiveness, and apoptosis rate under oxidative stress conditions through activation of the SIRT1/Nrf2/HO-1 pathway.
DOI: 10.5281/zenodo.10218788
title: Origianl data for publication: Anchoring of Metal Complexes on Au25 Nanocluster for Enhanced Photocoupled Electrocatalytic CO2 Reduction

description: The file contains the original data for the publication: Anchoring of Metal Complexes on Au25 Nanocluster for Enhanced Photocoupled Electrocatalytic CO2 Reduction.
Angew. Chem. Int. Ed. 2023. doi.org/10.1002/anie.202316649.
The data is grouped acording to the figures in the manuscript and the supporting information.
DOI: 10.5281/zenodo.10218789
title: Origianl data for publication: Anchoring of Metal Complexes on Au25 Nanocluster for Enhanced Photocoupled Electrocatalytic CO2 Reduction

description: The file contains the original data for the publication: Anchoring of Metal Complexes on Au25 Nanocluster for Enhanced Photocoupled Electrocatalytic CO2 Reduction.
Angew. Chem. Int. Ed. 2023. doi.org/10.1002/anie.202316649.
The data is grouped acording to the figures in the manuscript and the supporting information.
DOI: 10.58060/v3qc-s402
title: EVA (European Vegetation Archive) and ReSurveyEurope - version 2023-01-27

description: The European Vegetation Archive is a collective database of vegetation plots from Europe and adjacent regions integrated into a single platform. Each plot contains a list of plant species in a specific small area, usually supplemented by an estimate of the cover of each species. EVA consists of individual databases owned by data contributors. Any use of the data from the individual databases is subject to the consent of the data owner. ReSurveyEurope is integrated as a subset of EVA. It contains vegetation-plot data with repeated measurements over time, including data from permanent plots and resurveys of vegetation survey plots.
DOI: 10.6084/m9.figshare.24461158
title: Lifetime data (Fig3e-f)

description: Lifetime data (Fig3e-f)