cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22337635.v1
title: Persistent changes in expression of genes involved in inflammation and fibrosis in the lungs of rats exposed to airborne lunar dust

description: NASA is currently planning return missions to the Moon for further exploration and research. The Moon is covered by a layer of potentially reactive fine dust, which could pose a toxicological risk of exposure to explorers. To assess this risk, we exposed rats to lunar dust (LD) that was collected during the Apollo14 mission. Rats were exposed to respirable sizes of LD at concentrations of 0, 2.1, 6.8, 20.8, or 60.6 mg/m<sup>3</sup> for 4 weeks. At thirteen  weeks after exposure, we assessed 44,000 gene transcripts and found the expression of 614 genes with known functions were significantly altered in the rats exposed to the 2 higher concentrations of LD, whereas few changes in gene expression were detected in the group exposed to the lowest concentration of LD. Many of the significant changes in gene expression involved genes known to be associated with inflammation or fibrosis. Four genes encoding pro-inflammatory chemokines were analyzed further for all the sampling points at 1 day, and 1, 4, and 13 weeks after the 4-week dust exposure, using real-time polymerase chain reaction. The expression of these genes was altered in a dose- and time-dependent manner and persistently changed in the lungs of the rats exposed to the two higher concentrations of LD. Their expressions are consistent with changes we detected in pulmonary toxicity biomarkers and pathology in these animals during a previous study. Because Apollo-14 LD contains common mineral oxides similar to an Arizona volcanic ash, besides revealing the toxicity of LD, our findings could help elucidate the genomic and molecular mechanisms involved in pulmonary toxicity induced by terrestrial mineral dusts.
DOI: 10.6084/m9.figshare.20764771
title: Effects of metabolic energy intervention on lipid content and liver transcriptome in finisher yellow-feathered chickens

description: High-energy diets improve growth rates and shorten the growth period while resulting in excessive fat deposition in the liver of birds. The effect of different energy diets on lipid content and liver transcriptome in finisher Huxu chickens was examined here. A total of 200 90-d-old Huxu chickens with an average BW of 1.08 kg were randomly divided into two dietary treatments. The birds were fed diets either containing 12.06 MJ ME/kg (low metabolic energy, LME) or 13.31 MJ ME/kg (high metabolic energy, HME) for 45 days. Chickens fed the HME diet had significantly higher total triglyceride and total cholesterol concentrations in both plasma and liver than did those fed the LME diet. Transcriptomic profiling showed 480 known differentially expressed genes (DEG), with 180 down-regulated and 300 up-regulated chickens from the HME diet compared with the LME diet. Notably, these genes were mostly enriched in lipid metabolism including the PPAR signalling pathway, fatty acid elongation, and glycerophospholipid metabolism. The relative mRNA expression level of 14 lipid metabolism-related genes, included 13 up-regulated (<i>MBOAT2</i>, <i>PLA2G2E</i>, <i>AGPAT2</i>, <i>AGPAT3</i>, <i>PCYT2</i>, <i>PEMT</i>, <i>ELOVL2</i>, <i>HADHA</i>, <i>ACOT1L</i>, <i>FABP3</i>, <i>FABP1</i>, <i>PLIN1</i>, <i>RXRG</i>) and one down-regulated (<i>LCAT</i>) gene. In conclusion, the present findings indicate that a high-energy diet likely regulates gene expression of the 14 lipid metabolism-related genes through the PPAR signalling pathway, fatty acid elongation, and glycerophospholipid metabolism resulting in excessive fat accumulation in the liver of Huxu chickens. These results provide a better understanding of the biological mechanisms by which the increased dietary energy induces fat accumulation in the liver.HighlightsA high-energy diet without change in protein level induced excessive fat accumulation in the Huxu chickens.Chickens fed the high-energy diet had induced higher total triglyceride and total cholesterol concentrations in both plasma and liver.This study showed a comprehensive profile of hepatic gene expression in chickens with fatty liver induced by high energy. A high-energy diet without change in protein level induced excessive fat accumulation in the Huxu chickens. Chickens fed the high-energy diet had induced higher total triglyceride and total cholesterol concentrations in both plasma and liver. This study showed a comprehensive profile of hepatic gene expression in chickens with fatty liver induced by high energy.
DOI: 10.6084/m9.figshare.20764771.v1
title: Effects of metabolic energy intervention on lipid content and liver transcriptome in finisher yellow-feathered chickens

description: High-energy diets improve growth rates and shorten the growth period while resulting in excessive fat deposition in the liver of birds. The effect of different energy diets on lipid content and liver transcriptome in finisher Huxu chickens was examined here. A total of 200 90-d-old Huxu chickens with an average BW of 1.08 kg were randomly divided into two dietary treatments. The birds were fed diets either containing 12.06 MJ ME/kg (low metabolic energy, LME) or 13.31 MJ ME/kg (high metabolic energy, HME) for 45 days. Chickens fed the HME diet had significantly higher total triglyceride and total cholesterol concentrations in both plasma and liver than did those fed the LME diet. Transcriptomic profiling showed 480 known differentially expressed genes (DEG), with 180 down-regulated and 300 up-regulated chickens from the HME diet compared with the LME diet. Notably, these genes were mostly enriched in lipid metabolism including the PPAR signalling pathway, fatty acid elongation, and glycerophospholipid metabolism. The relative mRNA expression level of 14 lipid metabolism-related genes, included 13 up-regulated (<i>MBOAT2</i>, <i>PLA2G2E</i>, <i>AGPAT2</i>, <i>AGPAT3</i>, <i>PCYT2</i>, <i>PEMT</i>, <i>ELOVL2</i>, <i>HADHA</i>, <i>ACOT1L</i>, <i>FABP3</i>, <i>FABP1</i>, <i>PLIN1</i>, <i>RXRG</i>) and one down-regulated (<i>LCAT</i>) gene. In conclusion, the present findings indicate that a high-energy diet likely regulates gene expression of the 14 lipid metabolism-related genes through the PPAR signalling pathway, fatty acid elongation, and glycerophospholipid metabolism resulting in excessive fat accumulation in the liver of Huxu chickens. These results provide a better understanding of the biological mechanisms by which the increased dietary energy induces fat accumulation in the liver.HighlightsA high-energy diet without change in protein level induced excessive fat accumulation in the Huxu chickens.Chickens fed the high-energy diet had induced higher total triglyceride and total cholesterol concentrations in both plasma and liver.This study showed a comprehensive profile of hepatic gene expression in chickens with fatty liver induced by high energy. A high-energy diet without change in protein level induced excessive fat accumulation in the Huxu chickens. Chickens fed the high-energy diet had induced higher total triglyceride and total cholesterol concentrations in both plasma and liver. This study showed a comprehensive profile of hepatic gene expression in chickens with fatty liver induced by high energy.
DOI: 10.5066/p9txzx5w
title: Field observation of wind waves and current velocity (2020) along the Fog Point Living Shoreline, Maryland

description: This dataset contains measurements of wave height, peak wave period, and water depth taken every 0.5 hours from February 13 to June 12, 2020, at three wave gauge locations along the Fog Point shoreline in Martin National Wildlife Refuge, Maryland. These wave gauges were continuously sampled at 10 Hz, capturing 20-minute bursts every 30 minutes (peak wave periods longer than 7s were removed). Additionally, the dataset includes measurements of current velocity at one location during the same period. A tilt current meter (TCM, Lowell Instruments LLC, short-TCMs, range of 0-60 cm/s), consisting of a tilt-corrected compass in a buoyant casing and attached to a concrete tile at the sediment surface, was used to measure current velocities. The TCM was sampled at 16 Hz in bursts of 20 seconds. The measured wave and current data were used for the analysis of wave attenuation along the living shoreline.
DOI: 10.6084/m9.figshare.10279079
title: MOESM5 of Rapid generation and selection of Cas9-engineering TRP53 R172P mice that do not have off-target effects

description: Additional file 5: Table S1. Summary of the analysis of the potential off-target loci. The top 10 potential off-target loci are PCR amplified and subsequently subjected to Sanger sequencing and aligned with mouse genome. Although no off-target effects of #2â€“10 loci are found on all the 4 mice, the off-target effects of #1 locus are detected in KI1 and KI3 mice.
DOI: 10.6084/m9.figshare.10279079.v1
title: MOESM5 of Rapid generation and selection of Cas9-engineering TRP53 R172P mice that do not have off-target effects

description: Additional file 5: Table S1. Summary of the analysis of the potential off-target loci. The top 10 potential off-target loci are PCR amplified and subsequently subjected to Sanger sequencing and aligned with mouse genome. Although no off-target effects of #2â€“10 loci are found on all the 4 mice, the off-target effects of #1 locus are detected in KI1 and KI3 mice.
DOI: 10.6084/m9.figshare.10279097
title: MOESM1 of Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5 years old in Guangxi, China

description: Additional file 1: Table S1. Abbreviations of counties’ name. In order to clearly recognize the location of each county in Fig. 1, we made this comparison table of abbreviations of counties’ name.
DOI: 10.6084/m9.figshare.10279097.v1
title: MOESM1 of Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5 years old in Guangxi, China

description: Additional file 1: Table S1. Abbreviations of counties’ name. In order to clearly recognize the location of each county in Fig. 1, we made this comparison table of abbreviations of counties’ name.
DOI: 10.6084/m9.figshare.25234006
title: Rúbrica analítica comentarios de texto

description: Con esta rúbrica analítica el profesor puede corregir desde el punto de vista cualitativo y cuantitativo aquellos ejercicios obtenidos del análisis crítico de fuentes primarias.
DOI: 10.6084/m9.figshare.25234006.v1
title: Rúbrica analítica comentarios de texto

description: Con esta rúbrica analítica el profesor puede corregir desde el punto de vista cualitativo y cuantitativo aquellos ejercicios obtenidos del análisis crítico de fuentes primarias.
DOI: 10.6084/m9.figshare.12900544
title: Additional file 2 of Multi-level consistent changes of the ECM pathway identified in a typical keratoconus twin’s family by multi-omics analysis

description: Additional file 2: Table S3. Five hundred eighty-nine differentially expressed genes in II-1-HCF cells with at least 2-fold change and false discovery rate p value ≤0.05.
DOI: 10.6084/m9.figshare.12900544.v1
title: Additional file 2 of Multi-level consistent changes of the ECM pathway identified in a typical keratoconus twin’s family by multi-omics analysis

description: Additional file 2: Table S3. Five hundred eighty-nine differentially expressed genes in II-1-HCF cells with at least 2-fold change and false discovery rate p value ≤0.05.
DOI: 10.6084/m9.figshare.10279106
title: MOESM2 of Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5â€‰years old in Guangxi, China

description: Additional file 2: Table S2. Collinearity Diagnostics. According to the results of Collinearity diagnostics, the maximum condition index is 512.831, which is greater than 50. And the variance proportions of temperature, the highest temperature and the lowest temperature are 99, 60 and 62%. There is multicollinearity between these variables.
DOI: 10.6084/m9.figshare.10279106.v1
title: MOESM2 of Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5â€‰years old in Guangxi, China

description: Additional file 2: Table S2. Collinearity Diagnostics. According to the results of Collinearity diagnostics, the maximum condition index is 512.831, which is greater than 50. And the variance proportions of temperature, the highest temperature and the lowest temperature are 99, 60 and 62%. There is multicollinearity between these variables.
DOI: 10.6084/m9.figshare.10279112
title: MOESM3 of Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5 years old in Guangxi, China

description: Additional file 3: Table S3. Collinearity statistics. A multicollinearity evaluation of these meteorological factors (including daily average temperature, daily average relative humidity, hot, cold and extreme humid) shows that the VIF are more than 10 units, indicating that the degree of confounding effects of the climate factors is not acceptable. So, we did not analyze the effect of extreme situation on the HFMD.
DOI: 10.6084/m9.figshare.10279112.v1
title: MOESM3 of Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5 years old in Guangxi, China

description: Additional file 3: Table S3. Collinearity statistics. A multicollinearity evaluation of these meteorological factors (including daily average temperature, daily average relative humidity, hot, cold and extreme humid) shows that the VIF are more than 10 units, indicating that the degree of confounding effects of the climate factors is not acceptable. So, we did not analyze the effect of extreme situation on the HFMD.
DOI: 10.25378/janelia.9754841
title: Voltron Simultaneous Ephys

description: Datasets from simultaneous Voltron imaging and electrophysiology in zebrafish.
DOI: 10.25378/janelia.9754841.v1
title: Voltron Simultaneous Ephys

description: Datasets from simultaneous Voltron imaging and electrophysiology in zebrafish.
DOI: 10.6084/m9.figshare.12900580
title: Additional file 4 of Diversity patterns of soil microbial communities in the Sophora flavescens rhizosphere in response to continuous monocropping

description: Additional file 4: Table S1. The identified core OTUs of the bacterial and fungal communities.
DOI: 10.6084/m9.figshare.12900580.v1
title: Additional file 4 of Diversity patterns of soil microbial communities in the Sophora flavescens rhizosphere in response to continuous monocropping

description: Additional file 4: Table S1. The identified core OTUs of the bacterial and fungal communities.
DOI: 10.6084/m9.figshare.10279145
title: MOESM1 of Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio)

description: Additional file 1. The raw data files.
DOI: 10.6084/m9.figshare.10279145.v1
title: MOESM1 of Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio)

description: Additional file 1. The raw data files.
DOI: 10.6084/m9.figshare.10279157
title: MOESM3 of Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio)

description: Additional file 3. Differentially expressed lnRNAs in the brains of male and female zebrafish.
DOI: 10.6084/m9.figshare.10279157.v1
title: MOESM3 of Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio)

description: Additional file 3. Differentially expressed lnRNAs in the brains of male and female zebrafish.
DOI: 10.5281/zenodo.10671583
title: Dataset Related to article: MUSCLE AND MUSCLE-LIKE AUTOANTIGEN EXPRESSION IN MYASTHENIA GRAVIS THYMUS: POSSIBLE MOLECULAR HINT FOR AUTOSENSITIZATION

description: Ct values obtained from real time PCR analysis of housekeeping gene and targets from MG thymuses with hyperplasia and thymoma, normal thymuses and non-MG thymomas.
DOI: 10.5281/zenodo.10671584
title: Dataset Related to article: MUSCLE AND MUSCLE-LIKE AUTOANTIGEN EXPRESSION IN MYASTHENIA GRAVIS THYMUS: POSSIBLE MOLECULAR HINT FOR AUTOSENSITIZATION

description: Ct values obtained from real time PCR analysis of housekeeping gene and targets from MG thymuses with hyperplasia and thymoma, normal thymuses and non-MG thymomas.
DOI: 10.6084/m9.figshare.12900598
title: Additional file 1 of The best choices: the diversity and functions of the plants in the home gardens of the Tsang-la (Motuo Menba) communities in Yarlung Tsangpo Grand Canyon, Southwest China

description: Additional file 1.
DOI: 10.6084/m9.figshare.12900598.v1
title: Additional file 1 of The best choices: the diversity and functions of the plants in the home gardens of the Tsang-la (Motuo Menba) communities in Yarlung Tsangpo Grand Canyon, Southwest China

description: Additional file 1.
DOI: 10.6084/m9.figshare.20764975
title: Dataset 2.docx

description: Table of the Buchdahl dispersion equation coefficients (a_1-a_6) for the 197 eco-friendly glasses used in the paper.
DOI: 10.6084/m9.figshare.20764975.v1
title: Dataset 2.docx

description: Table of the Buchdahl dispersion equation coefficients (a_1-a_6) for the 197 eco-friendly glasses used in the paper.
DOI: 10.6084/m9.figshare.12900671
title: Additional file 2 of Genome-wide analysis of long non-coding RNAs in adult tissues of the melon fly, Zeugodacus cucurbitae (Coquillett)

description: Additional file 2: Table S1. Primer sequences used for RT-qPCR.
DOI: 10.6084/m9.figshare.12900671.v1
title: Additional file 2 of Genome-wide analysis of long non-coding RNAs in adult tissues of the melon fly, Zeugodacus cucurbitae (Coquillett)

description: Additional file 2: Table S1. Primer sequences used for RT-qPCR.
DOI: 10.6084/m9.figshare.12900632.v1
title: Additional file 2 of Using three statistical methods to analyze the association between exposure to 9 compounds and obesity in children and adolescents: NHANES 2005-2010

description: Additional file 2. Datasets generated and analyzed during the current study.
DOI: 10.6084/m9.figshare.12900632
title: Additional file 2 of Using three statistical methods to analyze the association between exposure to 9 compounds and obesity in children and adolescents: NHANES 2005-2010

description: Additional file 2. Datasets generated and analyzed during the current study.
DOI: 10.6084/m9.figshare.12900653
title: Additional file 1 of Identification and validation of stemness-related lncRNA prognostic signature for breast cancer

description: Additional file 1. The list of 1198 BCSC-related lncRNAs.
DOI: 10.6084/m9.figshare.12900653.v1
title: Additional file 1 of Identification and validation of stemness-related lncRNA prognostic signature for breast cancer

description: Additional file 1. The list of 1198 BCSC-related lncRNAs.
DOI: 10.6084/m9.figshare.12900656
title: Additional file 2 of Identification and validation of stemness-related lncRNA prognostic signature for breast cancer

description: Additional file 2. The list of 213 BCSC-related mRNAs.
DOI: 10.6084/m9.figshare.12900656.v1
title: Additional file 2 of Identification and validation of stemness-related lncRNA prognostic signature for breast cancer

description: Additional file 2. The list of 213 BCSC-related mRNAs.
DOI: 10.6084/m9.figshare.12900697
title: Additional file 7 of RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

description: Additional file 7.
DOI: 10.6084/m9.figshare.12900697.v1
title: Additional file 7 of RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

description: Additional file 7.
DOI: 10.6084/m9.figshare.12900700
title: Additional file 8 of RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

description: Additional file 8.
DOI: 10.6084/m9.figshare.12900700.v1
title: Additional file 8 of RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

description: Additional file 8.
DOI: 10.6084/m9.figshare.12900703
title: Additional file 9 of RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

description: Additional file 9.
DOI: 10.6084/m9.figshare.12900703.v1
title: Additional file 9 of RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

description: Additional file 9.
DOI: 10.6084/m9.figshare.16570725
title: Exploration of differentially-expressed exosomal mRNAs, lncRNAs and circRNAs from serum samples of gallbladder cancer and xantho-granulomatous cholecystitis patients

description: Gallbladder cancer (GBC) is the most common biliary tract malignancy worldwide. Although a growing number of studies have explored the mechanism of GBC, thus far, few molecules have been discovered that can be utilized as specific biomarkers for the early diagnosis and therapeutic treatment of GBC. Recent studies have shown that exosomes not only participate in the progression of tumors, but also carry specific information that can define multiple cancer types. The present study investigated the expression profiles of coding (or messenger) ribonucleic acids (mRNAs) and non-coding RNAs (ncRNAs, including long non-coding RNAs [lncRNAs] and circular RNAs [circRNAs]) in plasma-derived exosomes from GBC patients. Using high-throughput RNA sequencing and subsequent bioinformatic analysis, a number of differentially expressed (DE) mRNAs, lncRNAs, and circRNAs were identified in GBC exosomes, compared to their expressions in xantho-granulomatous cholecystitis (XGC) exosomes. Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) analyses were then conducted to investigate the potential functions of these DE RNAs. Furthermore, the interaction networks and competing endogenous RNA networks of these DE RNAs and their target genes were investigated, revealing a complex regulatory network among mRNAs and ncRNAs. In summary, this study demonstrates the diagnostic value of plasma-derived exosomes in GBC and provides a new perspective on the mechanism of GBC.
DOI: 10.6084/m9.figshare.16570725.v2
title: Exploration of differentially-expressed exosomal mRNAs, lncRNAs and circRNAs from serum samples of gallbladder cancer and xantho-granulomatous cholecystitis patients

description: Gallbladder cancer (GBC) is the most common biliary tract malignancy worldwide. Although a growing number of studies have explored the mechanism of GBC, thus far, few molecules have been discovered that can be utilized as specific biomarkers for the early diagnosis and therapeutic treatment of GBC. Recent studies have shown that exosomes not only participate in the progression of tumors, but also carry specific information that can define multiple cancer types. The present study investigated the expression profiles of coding (or messenger) ribonucleic acids (mRNAs) and non-coding RNAs (ncRNAs, including long non-coding RNAs [lncRNAs] and circular RNAs [circRNAs]) in plasma-derived exosomes from GBC patients. Using high-throughput RNA sequencing and subsequent bioinformatic analysis, a number of differentially expressed (DE) mRNAs, lncRNAs, and circRNAs were identified in GBC exosomes, compared to their expressions in xantho-granulomatous cholecystitis (XGC) exosomes. Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) analyses were then conducted to investigate the potential functions of these DE RNAs. Furthermore, the interaction networks and competing endogenous RNA networks of these DE RNAs and their target genes were investigated, revealing a complex regulatory network among mRNAs and ncRNAs. In summary, this study demonstrates the diagnostic value of plasma-derived exosomes in GBC and provides a new perspective on the mechanism of GBC.