cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14053811
title: Supplementary Material for: A Novel Multi-Action Emollient Plus Cream Improves Skin Barrier Function in Patients with Atopic Dermatitis: In vitro and Clinical Evidence

description: <b><i>Background:</i></b> Emollients capable of restoring the skin barrier function would extend their role beyond basic maintenance therapy in atopic dermatitis (AD). <b><i>Objectives:</i></b> Investigate the effect of a novel emollient plus cream (EC; Dermoflan®) on the skin barrier in vitro and in patients with mild-to-moderate AD. <b><i>Methods:</i></b> The effect of EC on the skin barrier recovery was evaluated using a tape-stripping (TS) model. After TS, organ cultures were treated with EC (undiluted or diluted 1:1 with water) and analyzed at 18–120 h using hematoxylin and eosin, Oil Red O, immunohistochemical, and immunofluorescent techniques. In a double-blind, randomized study, EC or placebo was applied once daily for 2 months to antecubital folds of the upper and lower limbs of patients with mild-to-moderate AD in clinical remission. Epidermal thickness, vascularization, and epidermal hydration were assessed by optical coherence tomography and corneometry, respectively, at baseline, and 1 and 2 months following treatment initiation. <b><i>Results:</i></b> Following TS, EC treatment significantly increased epidermal thickness and lipid content versus diluent in the skin organ culture, as well as claudin-1, involucrin, and caspase-14 expression, suggesting skin barrier repair. EC treatment also decreased keratin-16 expression and increased levels of Toll-like receptors 1 and 2 versus diluent, suggesting involvement in regulating the epidermal immune response. In 20 patients randomized 1:1 to EC or placebo, EC treatment at the elbow fold/popliteal fossa significantly decreased epidermal thickness after 2 months, and the number of blood vessels at the elbow fold after 1 and 2 months, versus placebo. EC significantly improved the skin hydration after 2 months versus baseline. <b><i>Conclusions:</i></b> This novel multi-action EC may help to restore epidermal homeostasis and improve the skin of patients with AD. Results indicate that this novel multi-action EC could be a valid adjuvant therapy in patients with AD. <b><i>Key Message:</i></b> Novel multi-action emollient cream helps to restore epidermal homeostasis and improves the skin affected by AD.
DOI: 10.6084/m9.figshare.14053811.v1
title: Supplementary Material for: A Novel Multi-Action Emollient Plus Cream Improves Skin Barrier Function in Patients with Atopic Dermatitis: In vitro and Clinical Evidence

description: <b><i>Background:</i></b> Emollients capable of restoring the skin barrier function would extend their role beyond basic maintenance therapy in atopic dermatitis (AD). <b><i>Objectives:</i></b> Investigate the effect of a novel emollient plus cream (EC; Dermoflan®) on the skin barrier in vitro and in patients with mild-to-moderate AD. <b><i>Methods:</i></b> The effect of EC on the skin barrier recovery was evaluated using a tape-stripping (TS) model. After TS, organ cultures were treated with EC (undiluted or diluted 1:1 with water) and analyzed at 18–120 h using hematoxylin and eosin, Oil Red O, immunohistochemical, and immunofluorescent techniques. In a double-blind, randomized study, EC or placebo was applied once daily for 2 months to antecubital folds of the upper and lower limbs of patients with mild-to-moderate AD in clinical remission. Epidermal thickness, vascularization, and epidermal hydration were assessed by optical coherence tomography and corneometry, respectively, at baseline, and 1 and 2 months following treatment initiation. <b><i>Results:</i></b> Following TS, EC treatment significantly increased epidermal thickness and lipid content versus diluent in the skin organ culture, as well as claudin-1, involucrin, and caspase-14 expression, suggesting skin barrier repair. EC treatment also decreased keratin-16 expression and increased levels of Toll-like receptors 1 and 2 versus diluent, suggesting involvement in regulating the epidermal immune response. In 20 patients randomized 1:1 to EC or placebo, EC treatment at the elbow fold/popliteal fossa significantly decreased epidermal thickness after 2 months, and the number of blood vessels at the elbow fold after 1 and 2 months, versus placebo. EC significantly improved the skin hydration after 2 months versus baseline. <b><i>Conclusions:</i></b> This novel multi-action EC may help to restore epidermal homeostasis and improve the skin of patients with AD. Results indicate that this novel multi-action EC could be a valid adjuvant therapy in patients with AD. <b><i>Key Message:</i></b> Novel multi-action emollient cream helps to restore epidermal homeostasis and improves the skin affected by AD.
DOI: 10.5517/ccdc.csd.cc25pm5p
title: CCDC 2016772: Experimental Crystal Structure Determination

description: Related Article: Sudesh M Morajkar, Bikshandarkoil R Srinivasan|2021|Indian J.Chem.,Sect.A:Inorg.,Bio-inorg.,Phys.,Theor.Anal.Chem.|60A|185|
DOI: 10.5517/ccdc.csd.cc26812m
title: CCDC 2033509: Experimental Crystal Structure Determination

description: Related Article: Valeriya Shcherbakova, Dmitry Dibchak, Mariya Snisarenko, Yevhen Skalenko, Aleksandr V. Denisenko, Anastasiia S. Kuznetsova, Pavel K. Mykhailiuk|2021|J.Org.Chem.|86|2200|doi:10.1021/acs.joc.0c02355
DOI: 10.5517/ccdc.csd.cc26813n
title: CCDC 2033510: Experimental Crystal Structure Determination

description: Related Article: Valeriya Shcherbakova, Dmitry Dibchak, Mariya Snisarenko, Yevhen Skalenko, Aleksandr V. Denisenko, Anastasiia S. Kuznetsova, Pavel K. Mykhailiuk|2021|J.Org.Chem.|86|2200|doi:10.1021/acs.joc.0c02355
DOI: 10.5517/ccdc.csd.cc25pm6q
title: CCDC 2016773: Experimental Crystal Structure Determination

description: Related Article: Sudesh M Morajkar, Bikshandarkoil R Srinivasan|2021|Indian J.Chem.,Sect.A:Inorg.,Bio-inorg.,Phys.,Theor.Anal.Chem.|60A|185|
DOI: 10.6084/m9.figshare.14053865
title: Supplementary Material for: Incidence of Retinal Detachment in Germany: Results from the Gutenberg Health Study

description: <b><i>Purpose:</i></b> To investigate the incidence of retinal detachment in the German population and to assess potential risk factors. <b><i>Methods:</i></b> The Gutenberg Health Study is a population-based cohort study in Mainz, Germany, including subjects (<i>n</i> = 15,010) with an age range from 35 to 74 years at baseline examination. Study participants underwent a comprehensive ophthalmological examination including distant-corrected visual acuity, refraction and slit-lamp examination at baseline examination. A computer-assisted telephone interview was conducted after 2.5 and 5 years, and health events were recorded. The 5-year cumulative incidence of retinal detachment was computed for the study sample and stratified on age decades. Risk factors were analyzed using logistic regression including age, sex, spherical equivalent, pseudophakia and prior laser retinal therapy. <b><i>Results:</i></b> 13,416 participants (age 52.2 ± 10.7 years, 48.8% female) were included in this analysis. Twenty-eight subjects had a retinal detachment in one eye, no subject had a retinal detachment in both eyes. The 5-year cumulative incidence of retinal detachment was 0.21% (95% CI 0.14–0.31%), the incidence rate was 42/100,000 person-years. Risk factors were male sex (OR 4.16, <i>p</i> = 0.004), pseudophakia (OR 3.93, <i>p</i> = 0.045) and myopia (OR 1.31 per diopter myopia, <i>p</i> &lt; 0.0001), but not prior retinal laser therapy or age. <b><i>Conclusion:</i></b> The incidence of retinal detachment in Germany at the age of 35–74 years is comparable to estimates from neighboring European countries. Risk factors are male sex, pseudophakia and myopia.
DOI: 10.15161/oar.it/73529
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.6084/m9.figshare.14053882
title: Sup data Fig.2 from Oviposition-site shift in phytophagous mites reflects a trade-off between predator avoidance and rainstorm resistance

description: Data for Figure 2
DOI: 10.6084/m9.figshare.14053882.v1
title: Sup data Fig.2 from Oviposition-site shift in phytophagous mites reflects a trade-off between predator avoidance and rainstorm resistance

description: Data for Figure 2
DOI: 10.6084/m9.figshare.14053888.v1
title: Sup data Egg position outdoors from Oviposition-site shift in phytophagous mites reflects a trade-off between predator avoidance and rainstorm resistance

description: Data of egg positions in the wild
DOI: 10.6084/m9.figshare.14053888
title: Sup data Egg position outdoors from Oviposition-site shift in phytophagous mites reflects a trade-off between predator avoidance and rainstorm resistance

description: Data of egg positions in the wild
DOI: 10.6084/m9.figshare.14053894.v1
title: Sup data Fig.1 from Oviposition-site shift in phytophagous mites reflects a trade-off between predator avoidance and rainstorm resistance

description: Data for Figure 1
DOI: 10.6084/m9.figshare.14053894
title: Sup data Fig.1 from Oviposition-site shift in phytophagous mites reflects a trade-off between predator avoidance and rainstorm resistance

description: Data for Figure 1
DOI: 10.6084/m9.figshare.14053911.v1
title: S2: Marie Byrd Land lithospheric mantle: a review of the xenolith record

description: Mineral major and trace element data, whole-rock major and trace element data
DOI: 10.6084/m9.figshare.14053911
title: S2: Marie Byrd Land lithospheric mantle: a review of the xenolith record

description: Mineral major and trace element data, whole-rock major and trace element data
DOI: 10.6084/m9.figshare.14053917.v1
title: Additional file 2 from Individual-based acoustic variation of the alarm calls in the long-tailed ground squirrel

description: Acoustic parameters measured from wideband alarms
DOI: 10.6084/m9.figshare.14053917
title: Additional file 2 from Individual-based acoustic variation of the alarm calls in the long-tailed ground squirrel

description: Acoustic parameters measured from wideband alarms
DOI: 10.6084/m9.figshare.14053932.v1
title: Additional file 1 from Individual-based acoustic variation of the alarm calls in the long-tailed ground squirrel

description: Acoustic parameters measured from whistles
DOI: 10.6084/m9.figshare.14053932
title: Additional file 1 from Individual-based acoustic variation of the alarm calls in the long-tailed ground squirrel

description: Acoustic parameters measured from whistles
DOI: 10.20351/29sg20190930
title: INSIGHT_LEG2 Cruise, RV Sarmiento de Gamboa

description: INSIGHT_LEG2 Cruise (29SG20190930) carried out on the Research Vessel Sarmiento de Gamboa in 2019
DOI: 10.20351/29he20190523
title: ZEE-2019 Cruise, RV Hespérides

description: ZEE-2019 Cruise (29HE20190523) carried out on the Research Vessel Hespérides in 2019
DOI: 10.5281/zenodo.4415787
title: WRF-Chem Volcano output - Etna Summer 2012

description: Output from a model run of a modified version of WRF-Chem, which we refer to as WRF-Chem Volcano (WCV). At the time of submission of this dataset, these data were the basis of the modelling part of a paper submitted imminently to [Atmospheric Chemistry and Physics Discussions (ACPD)]: "Observation and modelling of ozone-destructive chemistry in a quiescent degassing volcanic plume". The code of WCV is maintained here. Development of this code will continue after the submission of this repository, This branch is a permanent record of the code as used to create this dataset.<br> This is a simulation of the chemistry of the degassing plume of Etna in July/August 2012. This simulation includes bromine, chlorine and mercury chemistry. The time period modelled for the main and novolc runs is the 29 July - 01 August, however the first 24 hours of simulation are considered to be "spin up" and these data are not uploaded here. Other runs were begun from the state of the <em>main</em> model run at 2012-08-01 00:00 and therefore only output for this one day exists. All data here relates to domain "d04", which is the innermost nest (see Figure 3 of paper). Data from multiple runs is uploaded here, see Table 2 of paper. <strong>Overview of files</strong> <strong><em>Output files: RUNNAME_wrfout_d04_YYYY-MM-DD_HH:MM:SS</em></strong> Output data is contained in NetCDF files. Each file contains hourly snapshots of the 3D simulation with fields for various parameters. Most of the 4D (three spatial dimensions and time) variables record modelled mixing ratios of various gaseous species (in units ppm) and aerosol species (separated by species and size bin, in units ug/kg-dry-air). Many other variables are standard WRF-Chem output variables; please see WRF-Chem's documentation. If the meaning of a variable is unclear, please contact the author. Each file covers a period of 24 hours. Runs <em>main</em>, <em>novolc</em> and <em>hal00</em> were run for the full model period. The other runs were run for 2012-08-01 only, beginning with the model state of <em>main</em> at 2012-08-01 00:00:00 <em><strong>WRF-Chem namelist files</strong></em> <em>namelist.wps</em> is the input file used for the WPS pre-processor (common to all runs). <em>namelist.input</em> is the input file used for WRF, this file is common to all runs with volcanic emissions. <em>namelist.input_novolc </em>is the input file used for the novolc run <strong><em>PREP-CHEM SRC input files: prep_chem_sources_RUNNAME.inp</em></strong> Input files for PrepChem for each run with volcanic emissions.
DOI: 10.5519/qd.jmfjcxc4
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (103 records)
DOI: 10.25625/s3gi5n/cmohyo
title: 20201129-MSc-Alamgir.pdf

description: :unav
DOI: 10.25625/s3gi5n
title: Design and implementation of an API to ease the use of HPC systems

description: High Performance Computing (HPC) is a practice of aggregating computing power such that it delivers high performance in order to solve large scale problems, typically in science or engineering. The classical approach that facilitates solving these complex problems by scientists and engineers does not scale very well due to the manual executions of jobs. Our work facilitate such use cases and works with GitLab (a web based DevOps life-cycle tool), Continuous Integration(CI) pipeline and CI runners to automate parameterized jobs execution over the HPC system for different use cases such as compile, build, analyse and HPC-enabled workflows. Our envisioned architecture accepts jobs as part of a workflow using our RESTful API for GitLab’s CI pipeline and schedules the jobs over the HPC system using our Cron Job while ensuring no unauthorized extraction and modification of personal or research data as well as no abuse of HPC resources by injecting jobs from API or Cron Job by building a security model on top. The final thesis was submitted in partial fulfilment of the requirements for the course “Internet Technologies and Information Systems”, supervised by Prof. Ramin Yahyapour and Dr. Sven Bingert.
DOI: 10.18112/openneuro.ds003520.v1.0.0
title: PIRACY
DOI: 10.12751/g-node.557cih
title: Longitudinal (4 wks) T2-weighted MRI and DTI of WT mice with cortical stroke (thromboembolic model) in C57BL/6 mice.

description: Longitudinal MRI including T2-weighted (T2w) and diffusion tensor imaging (DTI) WT mice with cortical stroke lesions induced by injection of thrombin and survival time of 4 weeks (4 wks).
DOI: 10.5517/ccdc.csd.cc23bmcg
title: CCDC 1946625: Experimental Crystal Structure Determination

description: Related Article: Xinxin Lin, Cuilian Zeng, Chengkou Liu, Zheng Fang, Kai Guo|2021|Org.Biomol.Chem.|19|1352|doi:10.1039/D0OB02055A
DOI: 10.5517/ccdc.csd.cc25x6jv
title: CCDC 2023107: Experimental Crystal Structure Determination

description: Related Article: Shaikh Samser, Priyabrata Biswal, Sushanta Kumar Meher, Krishnan Venkatasubbaiah|2021|Org.Biomol.Chem.|19|1386|doi:10.1039/D0OB02515A
DOI: 10.5517/ccdc.csd.cc261kwq
title: CCDC 2027303: Experimental Crystal Structure Determination

description: Related Article: Masato Tsuda, Taiki Morita, Shintaro Fukuhara, Hiroyuki Nakamura|2021|Org.Biomol.Chem.|19|1358|doi:10.1039/D0OB02544E
DOI: 10.5517/ccdc.csd.cc26q1dd
title: CCDC 2046973: Experimental Crystal Structure Determination

description: Related Article: Hai-Qing Wang, Wenjing Ma, Ao Sun, Xin-Yue Sun, Chao Jiang, Yu-Chen Zhang, Feng Shi|2021|Org.Biomol.Chem.|19|1334|doi:10.1039/D0OB02388D
DOI: 10.6084/m9.figshare.14054057
title: Supplementary Material for: Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway

description: <b><i>Background and Objective:</i></b> Epidemiological evidence suggests that the antidiabetic drug metformin (MET) can also inhibit abdominal aortic aneurysm (AAA) formation. However, the underlying protective mechanism remains unknown. It has been reported that phosphorylated AMP-activated protein kinase (AMPK) levels are significantly lower in AAA tissues than control aortic tissues. AMPK activation can inhibit the downstream signaling molecule called mechanistic target of rapamycin (mTOR), which has also been reported be upregulated in thoracic aneurysms. Thus, blocking mTOR signaling could attenuate AAA progression. MET is a known agonist of AMPK. Therefore, in this study, we investigated if MET could inhibit formation of AAA by activating the AMPK/mTOR signaling pathway. <b><i>Materials and Methods:</i></b> The AAA animal model was induced by intraluminal porcine pancreatic elastase (PPE) perfusion in male Sprague Dawley rats. The rats were treated with MET or compound C (C.C), which is an AMPK inhibitor. AAA formation was monitored by serial ultrasound. Aortas were collected 4 weeks after surgery and subjected to immunohistochemistry, Western blot, and transmission electron microscopy analyses. <b><i>Results:</i></b> MET treatment dramatically inhibited the formation of AAA 4 weeks after PPE perfusion. MET reduced the aortic diameter, downregulated both macrophage infiltration and matrix metalloproteinase expression, decreased neovascularization, and preserved the contractile phenotype of the aortic vascular smooth muscle cells. Furthermore, we detected an increase in autophagy after MET treatment. All of these effects were reversed by the AMPK inhibitor C.C. <b><i>Conclusion:</i></b> This study demonstrated that MET activates AMPK and suppresses AAA formation. Our study provides a novel mechanism for MET and suggests that MET could be potentially used as a therapeutic candidate for preventing AAA.
DOI: 10.5281/zenodo.4548158
title: Surveillance of equine strangles in the United Kingdom between 2015 and 2019 based on laboratory detection of Streptococcus equi: Datasets and analysis code

description: This repository contains datasets and code used for the manuscript as titled above
DOI: 10.25625/jwcfpd/kcwpz7
title: Bumble_cleaned.tab

description: Cleaned data: recorded bumblebee-plant interactions
DOI: 10.25625/jwcfpd/eyiboi
title: Plant_survey_raw.tab

description: Raw data of flowering plant survey
DOI: 10.25625/jwcfpd/ukgtak
title: Bumble_pooled_for_analysis.tab

description: Pooled dataset for analysis in R: Bumblebee abundance, species richness, plant data and landscape parameters
DOI: 10.25625/jwcfpd/go8p4m
title: Metadata_pollen_detailed.tab

description: Metadata for sequenced bumblebee pollen samples
DOI: 10.25625/jwcfpd/yarz4a
title: Pollen_SRA_URL.txt

description: URLs to each sequenced pollen sample, deposited in the NCBI Sequence Read Archive.
DOI: 10.25625/jwcfpd
title: Replication Data for: "Effects of three flower field types on bumblebees and their pollen diets"

description: Dataset containing species richness and abundance of bumblebees, flowering plants, land use, environmenta background data, as well as metadata and accession URLs for sequenced pollen samples. For details please see the original publication.
DOI: 10.20351/29gd20031111
title: EFLUBIO-1 Cruise, RV García del Cid

description: EFLUBIO-1 Cruise (29GD20031111) carried out on the Research Vessel García del Cid in 2003
DOI: 10.6084/m9.figshare.14054076.v1
title: Statistical parametric mapping of biomechanical one-dimensional data with Bayesian inference

description: Recent developments in Statistical Parametric Mapping (SPM) for continuum data (e.g. kinematic time series) have been adopted by the biomechanics research community with great interest. The Python/MATLAB package spm1d developed by T. Pataky has introduced SPM into the biomechanical literature, adapted originally from neuroimaging. The package already allows many of the statistical analyses common in biomechanics from a frequentist perspective. In this paper, we propose an application of Bayesian analogs of SPM based on Bayes factors and posterior probability with default priors using the BayesFactor package in R. Results are provided for two typical designs (two-sample and paired sample <i>t</i>-tests) and compared to classical SPM results, but more complex standard designs are possible in both classical and Bayesian frameworks. The advantages of Bayesian analyses in general and specifically for SPM are discussed. Scripts of the analyses are available as supplementary materials.
DOI: 10.6084/m9.figshare.8221103.v1
title: Data mining the effects of testing conditions and specimen properties on brain biomechanics

description: Traumatic brain injury is highly prevalent in the United States. However, despite its frequency and significance, there is little understanding of how the brain responds during injurious loading. A confounding problem is that because testing conditions vary between assessment methods, brain biomechanics cannot be fully understood. Data mining techniques, which are commonly used to determine patterns in large datasets, were applied to discover how changes in testing conditions affect the mechanical response of the brain. Data at various strain rates were collected from published literature and sorted into datasets based on strain rate and tension vs. compression. Self-organizing maps were used to conduct a sensitivity analysis to rank the testing condition parameters by importance. Fuzzy C-means clustering was applied to determine if there were any patterns in the data. The parameter rankings and clustering for each dataset varied, indicating that the strain rate and type of deformation influence the role of these parameters in the datasets.
DOI: 10.6084/m9.figshare.14054076
title: Statistical parametric mapping of biomechanical one-dimensional data with Bayesian inference

description: Recent developments in Statistical Parametric Mapping (SPM) for continuum data (e.g. kinematic time series) have been adopted by the biomechanics research community with great interest. The Python/MATLAB package spm1d developed by T. Pataky has introduced SPM into the biomechanical literature, adapted originally from neuroimaging. The package already allows many of the statistical analyses common in biomechanics from a frequentist perspective. In this paper, we propose an application of Bayesian analogs of SPM based on Bayes factors and posterior probability with default priors using the BayesFactor package in R. Results are provided for two typical designs (two-sample and paired sample <i>t</i>-tests) and compared to classical SPM results, but more complex standard designs are possible in both classical and Bayesian frameworks. The advantages of Bayesian analyses in general and specifically for SPM are discussed. Scripts of the analyses are available as supplementary materials.