cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17694647.v1
title: Supplementary Material for: Unlocking Access to Broad Molecular Profiling: Benefits, Barriers, and Policy Solutions

description: <b><i>Objectives:</i></b> “Personalized healthcare” is generating new approaches to disease management by considering inter-individual variability in genes, environment, and lifestyle. Technologies such as comprehensive genomic profiling (CGP) are drivers of this shift. Here, we address the significant hurdles to the equitable implementation of CGP into routine clinical practice. <b><i>Methods:</i></b> This article draws on published evidence on the value of genomic profiling, as well as interviews with nine academic and clinical experts from six different countries to validate findings and test policy proposals for reforms. <b><i>Results:</i></b> The potential benefits of CGP extend beyond direct patient outcomes, to healthcare systems with societal and economic impacts. Among key barriers impeding integration into routine clinical practice are the lack of infrastructure to ensure reliable clinical testing and the limited understanding of genomics among healthcare personnel. In addition, the absence of health economic evidence supporting broader use of CGP is creating concerns for payers regarding the systemic benefits and affordability of this technology. <b><i>Conclusion:</i></b> Policy proposals that aim to improve equitable patient access to CGP will need to consider new funding models, health technology assessment processes that capture both patient and systemic benefits, and appropriate regulatory standards to determine the quality of genomic profiling tests.
DOI: 10.6084/m9.figshare.23541285.v1
title: Suppl table 2.xlsx

description: <strong>14C ages of the Revine chronologies from group 1&3 from group 2 and from group 4</strong>
DOI: 10.6084/m9.figshare.28876808.v2
title: pheno and gene data from OMIM and Clinvar

description: Genetic and phenotypic data obtained from Clinvar and OMIM websites
DOI: 10.6084/m9.figshare.16434885.v2
title: Datos procesados proyecto RETOS final

description: Dataset general de las variables asociadas a los mensajes recabados de grupos políticos analizados en proyecto DisinformationPoliticsLab, financiado por la Universidad Internacional de la Rioja (UNIR). En este dataset, se encuentran los datos de dependencia estadística asociada a la coocurrencia entre mensajes publicados y contenidos desinformativos identificados en Maldita.es y Newtral.es. También se incluye en este Dataset el análisis sentimental y hatespeech asociado a los grupos políticos analizados. Agradecimientos a Possible Incorporated SL por tu apoyo en la recopilación y el procesamiento de todos los datos en los que se basa este trabajo.
DOI: 10.6084/m9.figshare.21548679.v1
title: Analog waveforms of the SSI doublets to the station COL

description: The waveforms are in the standard Seismic Analysis Code (SAC) format. Bandpass filters can be further applied before making cross-correlation and time-shift measurements. Please see Supplementary Table 5 of Yang and Song (2022, Nature Geoscience) for the ranges of the filters we used for different SSI doublets.
DOI: 10.6084/m9.figshare.28673540.v1
title: Training data, trained models and other required files for 'A User-Tunable Machine Learning Framework for Step-Wise Synthesis Planning'.

description: We introduce MHNpath, a machine learning-driven retrosynthetic tool designed for computer-aided synthesis planning. Leveraging modern Hopfield networks and novel comparative metrics, MHNpath efficiently prioritizes reaction templates, improving the scalability and accuracy of retrosynthetic predictions. The tool incorporates a tunable scoring system that allows users to prioritize pathways based on cost, reaction temperature, and toxicity, thereby facilitating the design of greener and cost-effective reaction routes. We demonstrate its effectiveness through case studies involving complex molecules from ChemByDesign, showcasing its ability to predict novel synthetic and enzymatic pathways. Furthermore, we benchmark MHNpath against existing frameworks, replicating experimentally validated "gold-standard" pathways from PaRoutes. Our case studies reveal that the tool can generate shorter, cheaper, moderate-temperature routes employing green solvents, as exemplified by compounds such as dronabinol, arformoterol, and lupinine.
DOI: 10.4121/uuid:9dc82d0c-a216-45f4-b88c-25ef07a0b1f2
title: Data underlying the study into the housing capacity of the inhabitants of Mount Elgon

description: A questionnaire guide, questionnaire instructions, a questionnaire in English and a questionnaire in Swahili for inhabitant dwelling capacity evaluation for household survey Mt. Elgon (Kenya). Including a dataset with the answers from 200 households.
DOI: 10.6084/m9.figshare.8280755.v1
title: prostate psychopathology Benign images

description: this is prostate histopathology dataset, which includes benign, g3 and g4<br><br><br>
DOI: 10.6084/m9.figshare.19766659.v1
title: data.xlsx

description: supply chain management
DOI: 10.6084/m9.figshare.7982393.v1
title: x-ray diffraction results

description: Five x-ray diffraction results of tight sandstone from Songliao Basin
DOI: 10.17632/6943g3jzzy.1
title: sEMG data

description: RMS of sEMG data for patient with chronic non-specific neck pain when doing resistance exercise in six directions under four conditions.
DOI: 10.6084/m9.figshare.16567386.v1
title: Supplementary Material for: The Landscape and Potential Regulatory Mechanism of Lysine 2-Hydroxyisobutyrylation of Protein in End-Stage Renal Disease

description: <b><i>Background:</i></b> Acetylation has a vital role in the pathogenesis of end-stage renal disease (ESRD). Lysine 2-hydroxyisobutyrylation (<i>K</i><sub>hib</sub>) is a novel type of acetylation. In this study, we aimed to reveal the key features of <i>K</i><sub>hib</sub> in peripheral blood monocytes (PBMCs) of patients with ESRD. <b><i>Method:</i></b> We combined TMT labeling with LC-MS/MS analysis to compare <i>K</i><sub>hib</sub> modification of PBMCs between 20 ESRD patients and 20 healthy controls. The pan 2-hydroxyisobutyrylation antibody-based affinity enrichment method was used to reveal the features of <i>K</i><sub>hib</sub>, and the bioinformatics analysis was conducted to analyze the pathology of these <i>K</i><sub>hib</sub>-modified proteins. <b><i>Result:</i></b> Compared to healthy controls, we identified 440 upregulated proteins and 552 downregulated proteins in PBMCs of ESRD, among which 579 <i>K</i><sub>hib</sub> sites on 324 upregulated proteins and 287 <i>K</i><sub>hib</sub> sites on 188 downregulated proteins were identified. The site abundance, distribution, and function of the <i>K</i><sub>hib</sub> protein were further analyzed. The bioinformatics analysis revealed that the Rho/ROCK signaling pathway was highly enriched in ESRD, suggesting that it might contribute to renal fibrosis in ESRD patients. <b><i>Conclusion:</i></b> In this study, we found that <i>K</i><sub>hib</sub>-modified proteins correlated with the occurrence and progression of ESRD.
DOI: 10.6084/m9.figshare.28102958.v8
title: Vector-to-Image Converted Building Footprints or Building Change Detection

description: We present a challenging change detection problem in vector building footprints, which is critical when detected changes are used to update existing vector databases. We formulate our change detection into an image recognition problem, where deep learning approaches can be used. And we explore a more explainable multi-stage workflow of deep models.1．<b>Python environment</b>: requirements.txt2．<b>Step-by-step instructions on reproducing the results</b><b>:</b> Instructions_on_reproducing.docx3．<b>Code</b><b>:</b> Code_Feature-Fusion-CNN.zip4．<b>Data</b><b>:</b> (1) bounding-box.zip, (2) fixed-window.zip, (3) displacement.zip, (4) discrepancy.zip,(5) window_size_10.zip, (6) window_size_20.zip, (7) window_size_30.zip, (8) window_size_40.zip<br><br>
DOI: 10.6084/m9.figshare.13116482.v1
title: Supplementary Material for: Incidence and Prognostic Impact of Intracranial Hemorrhage after Endovascular Treatment for Acute Large Vessel Occlusion

description: <b><i>Introduction:</i></b> Endovascular treatment (EVT) is effective against acute cerebral large vessel occlusion (LVO). However, it has been associated with a high incidence of intracranial hemorrhage (ICH). Because the incidence of ICH and prognostic impact of ICH were not scrutinized in general patients, we investigated the impact of ICH after EVT on functional outcome at 90 days in patients with acute LVO. <b><i>Methods:</i></b> RESCUE-Japan Registry 2 was a multicenter registry that enrolled 2,420 consecutive patients with acute LVO within 24 h of onset. We analyzed 1,281 patients who received EVT and compared the functional outcomes between those with and without ICH (ICH and no-ICH groups, respectively) within 24 h after EVT. We explored the factors associated with ICH and prognostic impact of symptomatic ICH (SICH) among patients with ICH. We estimated the adjusted odds ratios (ORs) for good functional outcome as modified Rankin Scale scores 0–2 and mortality. We also explored the prognostic impact of symptomatic ICH (SICH) among patients with ICH. <b><i>Results:</i></b> ICH occurred in 333 patients (26.0%). Several factors such as perioperative edaravone, stent retriever, and baseline glucose were associated with development of ICH within 24 h. A good outcome was observed in 80 (24.0%) and 454 (47.9%) patients in the ICH and no-ICH groups, respectively, and the adjusted OR was 0.3 (95% confidence interval [CI] = 0.2–0.5, <i>p</i> &lt; 0.0001). Incidence of mortality within 90 days was not significantly different between the groups (adjusted OR 1.2; 95% CI: 0.7–1.9, <i>p</i> = 0.5). SICH was observed in 36 (10.8%) of 333 patients with ICH, and the good outcomes were 8.3 and 25.9% in patients with SICH and asymptomatic ICH (AICH), respectively (<i>p</i> = 0.02). Mortality at 90 days was 30.6 and 7.1% in patients with SICH and AICH, respectively (<i>p</i> &lt; 0.0001). <b><i>Conclusions:</i></b> The functional outcomes at 90 days were significantly worse in patients who developed ICH after receiving EVT for acute LVO, but the mortality was generally similar.
DOI: 10.6084/m9.figshare.21788777.v2
title: Dataset for Sustainable Development in Poor Areas

description: Datasets for Figure 2 and Figure 3
DOI: 10.6084/m9.figshare.25847371.v1
title: Supplementary Material for: Valley index as a predictor of prenatal diagnosis of total anomalous pulmonary venous connection

description: Introduction: Total anomalous pulmonary venous connection (TAPVC) has a low prenatal diagnostic rate. Therefore, we investigated whether Doppler waveforms with a low pulsatility in the pulmonary veins can indicate fetal TAPVC.
Methods: This retrospective study included 16 fetuses with TAPVC, including 10 with complex congenital heart disease and 104 healthy fetuses that underwent fetal echocardiography. Pulmonary venous S and D wave flow velocities and the valley (representing the lowest velocity between the S and D waves) were measured. Valley indices I and II were then calculated as (velocity of valley/ greater of the S and D wave velocities) and (velocity of valley/lesser of the S and D wave velocities), respectively.
Results: Supra/infracardiac TAPVC cases exhibited significantly greater valley indices than that of the healthy group. After adjusting for gestational age at fetal echocardiography, valley index I (odds ratio [OR] 7.26, p &lt; 0.01) and II (OR 9.23, p &lt; 0.01) were significant predictors of supra/infracardiac TAPVC. Furthermore, valley indices I and II exhibited a high area under the curve for detecting supra/infracardiac TAPVC, regardless of the presence of pulmonary venous obstruction. 
Conclusion: The valley index may be a useful tool for the detection of fetal TAPVC.
DOI: 10.6084/m9.figshare.26582044.v1
title: Generation and characterization of a variant of Thermostable Moloney Murine Leukemia Virus Reverse Transcriptase Enzyme

description: Reverse Transcriptase (RT) enzymes have been extensively utilized, especially in Polymerase Chain Reaction (PCR). Many viruses that cause infections worldwide contain ribonucleic acid (RNA), and for their molecular detection, it is essential to convert RNA to DNA using RT. This study aimed to create and characterize a thermostable Moloney Murine Reverse Transcriptase (MMLV-RT) enzyme by using consensus sequences from the latest MMLV-RT sequence database.
DOI: 10.6084/m9.figshare.27159747.v1
title: Supplementary Material for: Global and Regional Burden of Vaccine-Associated Erythema Multiforme and their Related Vaccines, 1967–2023: An In-Depth Analysis of the World Health Organization Pharmacovigilance Database

description: Objective: Vaccine-associated erythema multiforme (EM) remains under-researched, impacting global vaccine safety evaluations. This study examines the global and regional burden of EM and its association with specific vaccines to optimize vaccination strategies. Materials and Methods: We analyzed data from the WHO pharmacovigilance database on vaccine-associated EM from 1967 to 2023 (n=131,255,418 reports). Reporting frequencies, reported odds ratios (ROR), and information components (IC) were calculated for 16 vaccines across 170 countries. Results: We identified 6,355 cases (males, n=3,182 [50.07%]) of vaccine-associated EM from a total of 46,378 reports of all-cause EM. While vaccine-associated EM has been consistently reported, there has been a notable increase in reported incidence particularly in 2010 and 2020. Measles, mumps, and rubella vaccines had the highest association with vaccine-associated EM reports (ROR, 8.75 [95% confidence interval (CI), 8.11–9.44]; IC, 3.10 [IC0.25, 2.97]), followed by hepatitis B (8.54 [7.66–9.51]; 3.06 [2.88]), hepatitis A (8.11 [7.01–9.39]; 2.98 [2.74]), typhoid (6.50 [4.75–8.90]; 2.60 [2.07]), encephalitis (5.86 [4.35–7.91]; 2.47 [1.96]), diphtheria, tetanus toxoids, pertussis, polio, and Hemophilus influenza type b (5.70 [5.42–5.99]; 2.46 [2.38]), pneumococcal (5.56 [5.11–6.06]; 2.45 [2.31]), rotavirus (4.96 [4.21–5.84]; 2.29 [2.01]), varicella-zoster (4.44 [3.99–4.95]; 2.13 [1.95]).Vaccine-associated EM reports were more strongly correlated with younger age groups and males. The overall fatality rate of vaccine-associated EM was 0.04%. Conclusions: The rise in vaccine-associated EM across multiple vaccines, especially in younger populations, highlights the need for closer monitoring and more informed vaccination practices to mitigate adverse reactions.
DOI: 10.6084/m9.figshare.22794719.v1
title: Golf Oynama Veri Seti

description: golf oynama kararına ait veri seti. Karar ağaçları örneği için hazırlanmıştır.
DOI: 10.6084/m9.figshare.19996643.v1
title: Burnout syndrome and resilience in medical students from a Brazilian public college in Salvador, Brazil

description: Abstract Introduction Burnout syndrome is highly prevalent among medical students. Whereas burnout syndrome has been associated with negative outcomes, like suicidal ideation, protective factors are still unknown. Objective To evaluate if there is an association between burnout syndrome and resilience in medical students, assessing covariates such as depressive symptoms, suicidal ideation, and religiosity. Method This cross-sectional study was carried out with a sample of 209 students from a medical school in Brazil. Burnout syndrome was assessed using the Maslach Burnout Inventory – Student Survey. Potential protective factors and aggravators to burnout syndrome were investigated using appropriate scales. Results Fifty-nine students (28.2%) presented burnout. Multivariate analysis showed that resilience was a protective factor (p &lt; 0.001), along with being older, married or having better academic performance. Depressive symptoms were positively associated with burnout. Religiosity was not a protective factor and suicidal ideation was not associated with burnout when adjusted for depressive symptoms. Conclusion Burnout is frequent among medical students, impacting mental health and academic performance. Resilience seems to be a protective factor, and the relationship between burnout and suicidal ideation is possibly mediated by depressive symptoms. Prospective studies are needed to further investigate the associations found in this study.
DOI: 10.6084/m9.figshare.23725722.v1
title: Dataset for: "<b>Social uncertainty promotes signal complexity during approaches in wild chimpanzees </b><b>(</b><b><i>Pan troglodytes verus</i></b><b>)</b><b><i> </i></b><b>and mangabeys (</b><b><i>Cercocebus atys atys</i></b><b>)</b><b>".</b>

description: Dataset used in '<b>Social uncertainty promotes signal complexity during approaches in wild chimpanzees (</b><b><i>Pan troglodytes verus</i></b><b>)</b><b><i> </i></b><b>and mangabeys (</b><b><i>Cercocebus atys atys</i></b><b>)', Grampp et al.</b>Collected in wild chimpanzees and mangabeys from the Taï National Park, Ivory Coast (TCP and TMP).
DOI: 10.6084/m9.figshare.12249572.v1
title: Radius of gyration

description: Median and IQR of users' radius of gyration in a province by week. The fields of the table are:- COD_PROV of the province;- SIGLA of the province;- DEN_PCM of the province;- days in the format yyyy-mm-dd.- median week, Q1 week and Q3 week with week in the format dd/mm-DD/MM where dd/mm} and DD/MM are the first and the last day of the week, respectively.<br>
DOI: 10.6084/m9.figshare.22188193.v1
title: Data_S_Evolutionary Aspects of Selenium Binding Protein 1

description: DS1 - Alighment of SBP Proteins DS2 - TaxIDs (NCBI) of eucaryotic species without SBP homologs DS3 - Protein IDs (UniProt) not previously known as SBP homologs (unexpected) DS4 - Jalview project file (Java executable) containing the alignment of Data_S1 with 43 invariant positions DS5 - Chimera session file (Python executable) with a known SBP structure and highlighted residues (see text)
DOI: 10.6084/m9.figshare.28855634.v1
title: Replication package for: "An Anatomy of 488 Faults from Defects4J Based on the Control- and Data-Flow Graph Representations of Programs"

description: Artifacts and replication package for "An Anatomy of 488 Faults from Defects4J Based on the Control- and Data-Flow Graph Representations of Programs".Fault classificationFault classifications stored in JSON format in <i>[</i><i>p</i><i>roj]_fc.json</i> per project and <i>faultclassification.json</i> over all projects.StatisticsCalculated in<i> statistics.ipynb</i>; resulting graphs stored in <i>figures/</i>.
DOI: 10.6084/m9.figshare.14813115.v2
title: Ambient plume tracer and sediment concentration

description: Tracer and sediment concentration measured during the ambient plume tracking. The data was measured by a tow-yo'ed ECOTriplet Scattering Fluorescence sensor. The background stratification was measured by a tow-yo'ed SBE911plus CTD sensor.<br>
DOI: 10.6084/m9.figshare.28841051.v1
title: Color Blind and Non-Color Blind Friendly Chart

description: Dataset on VA Lung Cancer for Biomedical Data Visualization Class by Professor Ahmet Coskun
DOI: 10.25403/upresearchdata.20108993.v1
title: Fluorescent quantum dot-mycolic acid probe for Mycobacterium tuberculosis antibody detection

description: Supplementary data for a thesis titled "Development of a fluorescent quantum dot-mycolic acid probe for Mycobacterium tuberculosis antibody detection". <br> The data contains the following three files: 1.Two excel sheets of processed data of detection of antibodies using ELISA test and Fluorescence method. 2. One excel sheet of processed data of UV-vis spectroscopy excel sheet contains: FT-IR spectroscopy, TEM analysis, Fluorescence Spectroscopy, and XRD analysis. <br> <br> <br> <br> <br> <br>
DOI: 10.6084/m9.figshare.20474256.v1
title: Figure 3 data set.xlsx

description: oxidative stress challenge cell viability
DOI: 10.17632/mw36j2nm7x.1
title: Regulatory mechanisms governing RNA-Binding Protein LIN-28 transcription

description: LIN28A is an RNA-binding protein that plays a central role in maintaining pluripotency and regulating developmental timing by suppressing let-7 miRNA biogenesis. While much is known about its downstream effects, how LIN28A itself is transcriptionally regulated has remained elusive. In this study, we identified multiple intragenic enhancers within the Lin28a locus that give rise to enhancer RNAs (eRNAs) exhibiting strand-specific expression and context-dependent activation. These eRNAs are not uniformly expressed but are activated in a sequential and combinatorial manner, depending on the type and timing of external stimuli. Functional studies demonstrate that antisense eRNAs are particularly important for proper Lin28a expression, and their depletion leads to impaired pluripotency maintenance, altered let-7 miRNA levels, and defective embryoid body formation. This regulation is dynamic: different eRNAs contribute at distinct phases of differentiation or under metabolic perturbations, fine-tuning Lin28a output in response to cellular cues. Our findings reveal that the transcriptional regulation of Lin28a is governed by an unexpectedly complex mechanism involving multiple eRNAs working in coordination, highlighting a broader role for eRNAs in modulating gene expression programs during early development.
DOI: 10.6084/m9.figshare.22358095.v1
title: Artifact for Syntax Is All You Need: A Universal-Language Approach to Mutant Generation

description: This is the artifact for the paper "Syntax Is All You Need: A Universal-Language Approach to Mutant Generation".
DOI: 10.6084/m9.figshare.14979657.v1
title: Supplementary Material for: Effects of Dingchuan Decoction on Lung Function and Clinical Effectiveness Rate in Children with Asthma: A Systematic Review and Meta-Analysis

description: Dingchuan decoction (DCD) is a traditional Chinese prescription for asthma that remains popular today. To systematically evaluate the effect of DCD on lung function, clinical effectiveness rate, and safety in children with asthma, significant databases were searched for randomized controlled trials from their inception to September 9, 2019. Randomized controlled trials assessing the effect of DCD on lung function and clinical effectiveness rate in children with asthma were included in this meta-analysis. The methodological quality of the included trials was assessed using the Cochrane risk of bias tool. RevMan 5.3 was used for data analysis. Fourteen studies with 1,384 children were reviewed. FEV<sub>1</sub> improvement rate (mean difference [MD] 12.50, 95% confidence interval [CI] 8.72–16.29), PEF improvement rate (MD 14.28, 95% CI 11.08–17.49), and clinical effectiveness rate (relative risk 1.19, 95% CI 1.14–1.25) significantly increased in the DCD group when compared to simple conventional medication. Four trials suggest that DCD is safe for children. In conclusion, the use of DCD combined with conventional medication improves lung function and clinical effectiveness rate better than simple conventional medication. However, the selected trials lack blinding and large-scale studies. Therefore, to better manage DCD in clinical practice, more randomized controlled trials and large-scale studies are required for further evaluation.
DOI: 10.6084/m9.figshare.17058602.v1
title: BCR sequence data

description: AID is required for SHM and antibody affinity maturation. To evaluate the effect of USP10 on AID-mediated SHM and affinity maturation, we first examined the BCR mutation frequency in NP-CGG-immunized USP10-B<sup>WT</sup> and USP10-B<sup>KO</sup> mice by antibody gene sequencing. After USP10-B<sup>WT</sup> and USP10-B<sup>KO</sup> mouse GC B cells were sorted by FACS, we sequenced the IgH VH186.2 germline, which encodes an NP-specific antibody, and the JH4 intronic region, which is irrelevant for affinity selection, thus, serves as a pure indicator of SHM efficiency. The overall mutation frequency of both JH4 and VH186.2 was substantially decreased in the absence of USP10 (Figure 3G), suggesting that SHM was impaired.