cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21582788
title: Additional file 5 of Prescreening of tumor samples for tumor-centric transcriptome analyses of lung adenocarcinoma

description: Additional file 5: Supplementary Table 3. Tumor cell percentage estimated via single-cell RNA sequencing (scRNA-seq) of patient samples.
DOI: 10.6084/m9.figshare.21582788.v1
title: Additional file 5 of Prescreening of tumor samples for tumor-centric transcriptome analyses of lung adenocarcinoma

description: Additional file 5: Supplementary Table 3. Tumor cell percentage estimated via single-cell RNA sequencing (scRNA-seq) of patient samples.
DOI: 10.6084/m9.figshare.21582797
title: Additional file 3 of A case control investigation of COVID-19 associated mucormycosis in India

description: Additional file 3. Table S1: Details of the genomic reads mapped, total reads, pangolin lineage and the accession numbers for each of the strains retrieved.
DOI: 10.6084/m9.figshare.21582797.v1
title: Additional file 3 of A case control investigation of COVID-19 associated mucormycosis in India

description: Additional file 3. Table S1: Details of the genomic reads mapped, total reads, pangolin lineage and the accession numbers for each of the strains retrieved.
DOI: 10.5517/ccdc.csd.cc282jc8
title: CCDC 2087799: Experimental Crystal Structure Determination

description: Related Article: R. Alan Aitken, Alexandra M. Z. Slawin|2022|Molbank|2022|M1482|doi:10.3390/M1482
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.21582897.v1
title: Data-Soil Respiration.xlsx

description: <strong>effects of precipitation frequency on soil respiration</strong>
DOI: 10.6084/m9.figshare.21582897
title: Data-Soil Respiration.xlsx

description: <strong>effects of precipitation frequency on soil respiration</strong>
DOI: 10.6084/m9.figshare.21582906.v1
title: Supplementary Material for: A Randomized Phase 2 Study of 5-Aminolevulinic Acid Hydrochloride and Sodium Ferrous Citrate for the Prevention of Nephrotoxicity Induced by Cisplatin-Based Chemotherapy of Lung Cancer

description: <b><i>Introduction:</i></b> Cisplatin-based chemotherapy was established in the 1980s, and it has been improved by the development of a short hydration protocol in lung cancer therapy. However, cisplatin-based chemotherapy is still associated with renal toxicity. Because 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC) is known to be a mitochondrial activator and a heme oxygenase-1 (HO-1) inducer, 5-ALA with SFC is speculated to mitigate cisplatin-induced renal inflammation. <b><i>Methods:</i></b> We investigated the effects of oral administration of 5-ALA with SFC for preventing cisplatin-based nephrotoxicity in patients with lung cancer and evaluated its benefits for patients who received cisplatin-based chemotherapy. The primary endpoint was the significance of the difference between the serum creatinine (sCr) levels of the patients administered 5-ALA with SFC and those given placebo after course 1 of chemotherapy. The difference in the estimated glomerular filtration rate (eGFR) between the two groups was also evaluated as the secondary endpoint. <b><i>Results:</i></b> The double-blind, randomized two-arm studies were conducted at 15 medical facilities in Japan; 54 male and 20 female patients with lung cancer who received cisplatin-based chemotherapy between the ages of 42 and 75 years were included in the study. The compliance rate was greater than 94% in the primary assessment and subsequent drug administration periods. All enrolled patients completed the four cycles of cisplatin-based chemotherapy with short hydration. The average level of sCr on day 22 of course 1 was 0.707 mg/dL in the group treated with 5-ALA and SFC and 0.735 mg/dL in the placebo group, respectively, and the sCr in the test group was significantly lower than that in the placebo group (<i>p =</i> 0.038). In addition, the eGFR was significantly higher in the SPP-003 group than in the placebo group up to day 1 of course 3 (84.66 and 75.68 mL/min/1.73 m<sup>2</sup>, respectively, <i>p =</i> 0.02) and kept better even after the last administration of the study drug (82.37 and 73.49 mL/min/1.73 m<sup>2</sup>, respectively, <i>p =</i> 0.013). <b><i>Conclusions:</i></b> The oral administration of 5-ALA with SFC is beneficial to patients undergoing cisplatin-based chemotherapy for lung cancer with short hydration.
DOI: 10.6084/m9.figshare.21061648
title: circRNA PLOD2 promotes tumorigenesis and Warburg effect in colon cancer by the miR-513a-5p/SIX1/LDHA axis

description: Increasing evidence has proved that circRNAs might act as potential biomarkers for tumor diagnosis and prognosis. However, the functions and mechanisms of multiple circRNAs in colon cancer remains unclear. Here, we found circPLOD2 was dramatically upregulated in colon cancer tissue and cell lines. In vitro CCK-8, colony formation and transwell assays, and in vivo tumor transplantation assay were performed and explored that circPLOD2 might promote tumor proliferation, migration and invasion in vitro and in vivo. Moreover, based on the analysis of RNA pull-down, RNA immunoprecipitation, luciferase and rescued assays, we confirmed that the interactions between circPLOD2, miR-513a-5p and SIX1. It suggested that circPLOD2 acted as a sponge of miR-513a-5p to regulate the activation of the target gene SIX1. In addition, as a key transcription factor of Warburg effect related genes, SIX1 was proved to enhance the transcriptional expression of LDHA by chromatin immunoprecipitation assay, thereby regulating glycolysis in colon cancer cells. Therefore, we identified that circPLOD2 promoted colon cancer progression through miR-513a-5p/SIX1/LDHA axis, and acted as a new biomarker for colon cancer prognosis and treatment.
DOI: 10.6084/m9.figshare.21061648.v1
title: circRNA PLOD2 promotes tumorigenesis and Warburg effect in colon cancer by the miR-513a-5p/SIX1/LDHA axis

description: Increasing evidence has proved that circRNAs might act as potential biomarkers for tumor diagnosis and prognosis. However, the functions and mechanisms of multiple circRNAs in colon cancer remains unclear. Here, we found circPLOD2 was dramatically upregulated in colon cancer tissue and cell lines. In vitro CCK-8, colony formation and transwell assays, and in vivo tumor transplantation assay were performed and explored that circPLOD2 might promote tumor proliferation, migration and invasion in vitro and in vivo. Moreover, based on the analysis of RNA pull-down, RNA immunoprecipitation, luciferase and rescued assays, we confirmed that the interactions between circPLOD2, miR-513a-5p and SIX1. It suggested that circPLOD2 acted as a sponge of miR-513a-5p to regulate the activation of the target gene SIX1. In addition, as a key transcription factor of Warburg effect related genes, SIX1 was proved to enhance the transcriptional expression of LDHA by chromatin immunoprecipitation assay, thereby regulating glycolysis in colon cancer cells. Therefore, we identified that circPLOD2 promoted colon cancer progression through miR-513a-5p/SIX1/LDHA axis, and acted as a new biomarker for colon cancer prognosis and treatment.
DOI: 10.6084/m9.figshare.20368344.v1
title: Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1

description: Increasing evidence has shown that circular RNAs (circRNAs) play critical roles in various diseases, including keloid. The purpose of this study was to investigate the role of circ_0057452 and related action mechanisms during the development of keloid. The expression levels of circ_0057452, microRNA-7-5p (miR-7-5p) and GRB2 associated binding protein 1 (GAB1) mRNA were determined by quantitative real-time PCR (qRT-PCR). Cell proliferation was evaluated using methylthiazolyldiphenyl-tetrazolium bromide (MTT) and 5-Ethynyl-2’-deoxyuridine (Edu) assays. Flow cytometry analysis was utilized to determine cell cycle distribution and cell apoptosis. Western blot assay was used to measure apoptosis-related, collagen synthesis-related, and GAB1 protein levels. Cell migration and invasion were detected by wound healing assay and transwell assay. The interaction between miR-7-5p and circ_0057452 or GAB1 was confirmed by dual-luciferase reporter, RNA pull-down, and RNA Immunoprecipitation (RIP) assays. Circ_0057452 and GAB1 were upregulated in keloid tissues and keloid fibroblasts (KFs), while miR-7-5p was downregulated. Circ_0057452 knockdown or miR-7-5p overexpression inhibited the proliferation, migration, invasion, and collagen synthesis and induced cell cycle arrest and apoptosis of KFs. MiR-7-5p was targeted by circ_0057452, and its inhibition overturned the effects of circ_0057452 knockdown. In addition, GAB1 was a target of miR-7-5p, and GAB1 upregulation abolished the role of miR-7-5p overexpression and circ_0057452 knockdown in KFs. Circ_0057452 regulated the expression of GAB1 by adsorbing miR-7-5p in KFs. Circ_0057452 knockdown suppressed keloid development by regulating miR-7-5p/GAB1 axis, which might provide a promising therapeutic target for keloid.
DOI: 10.6084/m9.figshare.20368344
title: Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1

description: Increasing evidence has shown that circular RNAs (circRNAs) play critical roles in various diseases, including keloid. The purpose of this study was to investigate the role of circ_0057452 and related action mechanisms during the development of keloid. The expression levels of circ_0057452, microRNA-7-5p (miR-7-5p) and GRB2 associated binding protein 1 (GAB1) mRNA were determined by quantitative real-time PCR (qRT-PCR). Cell proliferation was evaluated using methylthiazolyldiphenyl-tetrazolium bromide (MTT) and 5-Ethynyl-2’-deoxyuridine (Edu) assays. Flow cytometry analysis was utilized to determine cell cycle distribution and cell apoptosis. Western blot assay was used to measure apoptosis-related, collagen synthesis-related, and GAB1 protein levels. Cell migration and invasion were detected by wound healing assay and transwell assay. The interaction between miR-7-5p and circ_0057452 or GAB1 was confirmed by dual-luciferase reporter, RNA pull-down, and RNA Immunoprecipitation (RIP) assays. Circ_0057452 and GAB1 were upregulated in keloid tissues and keloid fibroblasts (KFs), while miR-7-5p was downregulated. Circ_0057452 knockdown or miR-7-5p overexpression inhibited the proliferation, migration, invasion, and collagen synthesis and induced cell cycle arrest and apoptosis of KFs. MiR-7-5p was targeted by circ_0057452, and its inhibition overturned the effects of circ_0057452 knockdown. In addition, GAB1 was a target of miR-7-5p, and GAB1 upregulation abolished the role of miR-7-5p overexpression and circ_0057452 knockdown in KFs. Circ_0057452 regulated the expression of GAB1 by adsorbing miR-7-5p in KFs. Circ_0057452 knockdown suppressed keloid development by regulating miR-7-5p/GAB1 axis, which might provide a promising therapeutic target for keloid.
DOI: 10.6084/m9.figshare.21582873.v1
title: Supplementary Material for: Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan

description: <b><i>Introduction:</i></b> C3 glomerulopathy (C3G) is a rare, progressive kidney disease resulting from dysregulation of the alternative pathway (AP) of complement. Biomarkers at baseline were investigated in patients with C3G who participated in two phase 2 studies with the factor D (FD) inhibitor, danicopan. <b><i>Methods:</i></b> Patients with biopsy-confirmed C3G, proteinuria ≥500 mg/day, and estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m<sup>2</sup> were enrolled into two studies (NCT03369236 and NCT03459443). Biomarker analysis was performed for patients with C3G confirmed by central pathology laboratory re-evaluation. Complement and clinical biomarkers, biopsy composite score, and activity and chronicity indices were assessed at baseline and analyzed by pairwise Spearman correlation analysis. <b><i>Results:</i></b> Twenty-nine patients were included in the analysis (median [interquartile range] age: 24.0 [10.0] years). Systemic complement AP activation was evident by reduced median concentrations of C3 and C5, elevated sC5b-9, and normal C4, relative to reference ranges. C3 showed strong pairwise correlations with C5 and sC5b-9 (<i>r</i> = 0.80 and −0.73, respectively; <i>p</i> &lt; 0.0001). Baseline Ba and FD concentrations were inversely correlated with eGFR (<i>r</i> = −0.83 and −0.87, respectively; <i>p</i> &lt; 0.0001). Urinary concentrations of sC5b-9 were correlated with both plasma sC5b-9 and proteinuria (<i>r</i> = 0.69 and <i>r</i> = 0.83, respectively; <i>p</i> &lt; 0.0001). Biopsy activity indices correlated strongly with biomarkers of systemic AP activation, including C3 (<i>r</i> = −0.76, <i>p</i> &lt; 0.0001), whereas chronicity indices aligned more closely with eGFR (<i>r</i> = −0.57, <i>p</i> = 0.0021). <b><i>Conclusion:</i></b> Associations among complement biomarkers, kidney function, and kidney histology may add to the current understanding of C3G and assist with the characterization of patients with this heterogenous disease.
DOI: 10.6084/m9.figshare.21582618.v1
title: Supplementary Material for: Development of the Story Telling Examination for Early Mild Cognitive Impairment (Pre-Mild Cognitive Impairment) Screening

description: <b><i>Introduction:</i></b> Cognitive function prior to mild cognitive impairment (MCI) has become a burgeoning interest. Tools used to detect this early period before MCI are being pilot-tested. This study aimed to develop a new test to detect pre-MCI and to examine its content validity and feasibility. <b><i>Methods:</i></b> The Story Telling Examination for Early MCI Screening (STEEMS), an audio cognitive test, was developed. It covers ten cognitive domains, e.g., executive function, language fluency, abstract reasoning. Face and content validity were examined by experts in geriatric psychiatry and psychology. The content validity index was 1.00. STEEMS comprised 12 items with 2–4 types of scoring. The tool was further examined in 16 pilot samples for feasibility among healthy participants having no cognitive impairment (Montreal Cognitive Assessment [MoCA] test score ≥25, Mini-Cog ≥3) and no depressive symptoms (Geriatric Depression Scale &lt;6). <b><i>Results:</i></b> The 16 healthy older individuals aged 59–73 years, mean age was 65.06 ± 4.07 years, were predominantly males (68.8%). STEEMS scores ranged from 10 to 25, with a mean of 18.38 (SD = 4.2). Thirteen percent obtained 100% correct on the STEEMS, 63% scored 68–92% correct, and 25% scored 40–60% correct. The pre-MCI scores are illustrated by a bell curve’s graphical depiction, suggesting a normal distribution probability distribution. Correlation between STEEMS and MoCA test scores was observed. STEEMS showed to be feasible for early elderly or late adults as being brief and easy to understand. The time spent to administer was predictably less than 7 min. <b><i>Discussion/Conclusion:</i></b> STEEMS could potentially serve as a tool for pre-MCI screening. Further study and investigation in a larger population are required.
DOI: 10.6084/m9.figshare.21582909
title: Reaction-time_data_For-share.xlsx

description: This is a cross-sectional study that included 64 graduate students who used a smartphone from the University of Phayao. They were randomly selected from strata based on city, age, and gender. Adolescents aged 18 to 22 were eligible for this study if they could converse adequately and had used smartphones for social media every day for at least a year before participation.
DOI: 10.6084/m9.figshare.21582909.v1
title: Reaction-time_data_For-share.xlsx

description: This is a cross-sectional study that included 64 graduate students who used a smartphone from the University of Phayao. They were randomly selected from strata based on city, age, and gender. Adolescents aged 18 to 22 were eligible for this study if they could converse adequately and had used smartphones for social media every day for at least a year before participation.
DOI: 10.5281/zenodo.3566780
title: Archaeological bitumen from Tell Abraq - GC-MS & d13C data

description: This dataset belongs to a research that was carried out on bitumen excavated at Tell Abraq, a Bronze Age period site located in the United Arab Emirates. Several bitumen samples from various contexts were sampled and subjected to both GC-MS and Stable Carbon Isotope Analysis. <br> This dataset holds:<br> -Measured d13C values<br> -GC-MS Raw Data (registered by Agilent Software)<br> -Peak surfaces and molecular ratios (both .xlsx and .csv format, both are identical)<br> -Photos linked to the samples
description: {"references": ["Van de Velde T., Magee P. & Lynen F. 2017. The bitumen imports at Tell Abraq - tracing the second millennium BC bitumen industry in south-east Arabia. Proceedings of the Seminar for Arabian Studies 47: 227-238"]}
DOI: 10.5281/zenodo.3566781
title: Archaeological bitumen from Tell Abraq - GC-MS & d13C data

description: This dataset belongs to a research that was carried out on bitumen excavated at Tell Abraq, a Bronze Age period site located in the United Arab Emirates. Several bitumen samples from various contexts were sampled and subjected to both GC-MS and Stable Carbon Isotope Analysis. <br> This dataset holds:<br> -Measured d13C values<br> -GC-MS Raw Data (registered by Agilent Software)<br> -Peak surfaces and molecular ratios (both .xlsx and .csv format, both are identical)<br> -Photos linked to the samples
description: {"references": ["Van de Velde T., Magee P. & Lynen F. 2017. The bitumen imports at Tell Abraq - tracing the second millennium BC bitumen industry in south-east Arabia. Proceedings of the Seminar for Arabian Studies 47: 227-238"]}
DOI: 10.6084/m9.figshare.21299412
title: Additional file 10 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 10. Standardcomplexes1.
DOI: 10.6084/m9.figshare.21299412.v1
title: Additional file 10 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 10. Standardcomplexes1.
DOI: 10.6084/m9.figshare.21299415
title: Additional file 11 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 11. Standardcomplexes2
DOI: 10.6084/m9.figshare.21299415.v1
title: Additional file 11 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 11. Standardcomplexes2
DOI: 10.6084/m9.figshare.21299418
title: Additional file 12 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 12. An example diagram to describe the Algorithm 2.
DOI: 10.6084/m9.figshare.21299418.v1
title: Additional file 12 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 12. An example diagram to describe the Algorithm 2.
DOI: 10.6084/m9.figshare.21299421
title: Additional file 13 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 13. An example diagram to describe the Algorithm 3.
DOI: 10.6084/m9.figshare.21299421.v1
title: Additional file 13 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 13. An example diagram to describe the Algorithm 3.
DOI: 10.6084/m9.figshare.21299424
title: Additional file 14 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 14. An example diagram to describe the Algorithm 5.
DOI: 10.6084/m9.figshare.21299424.v1
title: Additional file 14 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 14. An example diagram to describe the Algorithm 5.
DOI: 10.6084/m9.figshare.21299427.v1
title: Additional file 15 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 15. Experimental results on String dataset.
DOI: 10.6084/m9.figshare.21299430
title: Additional file 16 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 16. Experimental results on DIP dataset.
DOI: 10.6084/m9.figshare.21299430.v1
title: Additional file 16 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 16. Experimental results on DIP dataset.
DOI: 10.6084/m9.figshare.21299433
title: Additional file 17 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 17. Experimental results on Biogrid dataset.
DOI: 10.6084/m9.figshare.21299427
title: Additional file 15 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 15. Experimental results on String dataset.
DOI: 10.6084/m9.figshare.21299433.v1
title: Additional file 17 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 17. Experimental results on Biogrid dataset.
DOI: 10.6084/m9.figshare.21299436
title: Additional file 18 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 18. Functional enrichment analysis of protein complexes detected in String, DIP and Biogrid datasets.
DOI: 10.6084/m9.figshare.21299436.v1
title: Additional file 18 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 18. Functional enrichment analysis of protein complexes detected in String, DIP and Biogrid datasets.
DOI: 10.6084/m9.figshare.21299460
title: Additional file 8 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 8. Go slim mapping.
DOI: 10.6084/m9.figshare.21299460.v1
title: Additional file 8 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 8. Go slim mapping.
DOI: 10.6084/m9.figshare.21299463
title: Additional file 9 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 9. Subcellular localization data.
DOI: 10.6084/m9.figshare.21299463.v1
title: Additional file 9 of Detecting protein complexes with multiple properties by an adaptive harmony search algorithm

description: Additional file 9. Subcellular localization data.
DOI: 10.6084/m9.figshare.21582930
title: effects of precipitation frequency on soil respiration

description: effects of precipitation frequency on soil respiration
DOI: 10.25375/uct.7454210
title: PI-SWERL measurement and Landsat dust source geo unit classification dataset for Namibia

description: This dataset contains PI-SWERL dust emission measurements and Landsat geomorphological unit dust source point data used in a paper entitled: Assessing landscape-scale dust emission potential using combined ground-based measurements and remote sensing data.
DOI: 10.25375/uct.7454210.v3
title: PI-SWERL measurement and Landsat dust source geo unit classification dataset for Namibia

description: This dataset contains PI-SWERL dust emission measurements and Landsat geomorphological unit dust source point data used in a paper entitled: Assessing landscape-scale dust emission potential using combined ground-based measurements and remote sensing data.