cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/112982
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1310 using a Furuno GP-150 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112984
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1310 using a Garmin GPS-17HVS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423532
title: SupplementaryData1.json

description: This dataset contains pixel values for upper and lower leaf-surfaces from images taken by a multispectral camera with filters mimicking avian spectral sensitivities. Raw pixel values have been normalized by the mean of each image, and represent relative quantum catches. Associated with each image set are the local date and time, habitat, and field site.
DOI: 10.7284/112985
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1310 using a Ashtech ADU2 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423532.v1
title: SupplementaryData1.json

description: This dataset contains pixel values for upper and lower leaf-surfaces from images taken by a multispectral camera with filters mimicking avian spectral sensitivities. Raw pixel values have been normalized by the mean of each image, and represent relative quantum catches. Associated with each image set are the local date and time, habitat, and field site.
DOI: 10.7284/112986
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1310 using a Furuno GP-90D instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112983
title: Gyrocompass data collected during research cruise NH1310 using a Sperry MK-37 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423457
title: Supplementary Material for: Analysis of Efficacy and Prognostic Factors of CLAG Treatment in Chinese Patients with Refractory or Relapsed Acute Myeloid Leukemia

description: <b><i>Background/Aims:</i></b> The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. <b><i>Methods:</i></b> Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m<sup>2</sup>/day cladribine (days 1–5), 2 g/m<sup>2</sup>/day cytarabine (days 1–5), and 300 μg/day filgrastim (days 0–5). The median follow-up duration was 10 months. <b><i>Results:</i></b> A total of 57 out of 67 patients were evaluable for remission after CLAG therapy, of whom 57.9% achieved a complete remission (CR) and the overall remission rate was 77.2%. The median overall survival (OS) was 10.0 months, with a 1-year OS of 40.3 ± 6.0% and 3-year OS of 16.7 ± 5.7%. CR at first induction after the initial diagnosis was associated with a favorable CR. Age above 60 years, high risk stratification, second or higher salvage therapy, and bone marrow (BM) blasts ≥42.1% were correlated with an unfavorable CR. Secondary disease, age ≥60 years, high risk stratification, and second or higher salvage therapy were associated with worse OS. Patients developed thrombocytopenia (41, 61%), febrile neutropenia (37, 55%), leukopenia (33, 49%), neutropenia (18, 27%), and anemia (9, 13%). <b><i>Conclusion:</i></b> CLAG was effective and well tolerated for R/R AML. BM blasts ≥42.1%, age ≥60 years, high risk stratification, and second or higher salvage therapy were independent factors for a poor prognosis.
DOI: 10.6084/m9.figshare.7423454
title: Wahbeh_Additional Data for Trance Channel Study

description: This fileset contains extended data for a manuscript. It includes the online survey administered, stories read by participants, and transcripts of open-ended responses.
DOI: 10.6084/m9.figshare.7423457.v1
title: Supplementary Material for: Analysis of Efficacy and Prognostic Factors of CLAG Treatment in Chinese Patients with Refractory or Relapsed Acute Myeloid Leukemia

description: <b><i>Background/Aims:</i></b> The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. <b><i>Methods:</i></b> Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m<sup>2</sup>/day cladribine (days 1–5), 2 g/m<sup>2</sup>/day cytarabine (days 1–5), and 300 μg/day filgrastim (days 0–5). The median follow-up duration was 10 months. <b><i>Results:</i></b> A total of 57 out of 67 patients were evaluable for remission after CLAG therapy, of whom 57.9% achieved a complete remission (CR) and the overall remission rate was 77.2%. The median overall survival (OS) was 10.0 months, with a 1-year OS of 40.3 ± 6.0% and 3-year OS of 16.7 ± 5.7%. CR at first induction after the initial diagnosis was associated with a favorable CR. Age above 60 years, high risk stratification, second or higher salvage therapy, and bone marrow (BM) blasts ≥42.1% were correlated with an unfavorable CR. Secondary disease, age ≥60 years, high risk stratification, and second or higher salvage therapy were associated with worse OS. Patients developed thrombocytopenia (41, 61%), febrile neutropenia (37, 55%), leukopenia (33, 49%), neutropenia (18, 27%), and anemia (9, 13%). <b><i>Conclusion:</i></b> CLAG was effective and well tolerated for R/R AML. BM blasts ≥42.1%, age ≥60 years, high risk stratification, and second or higher salvage therapy were independent factors for a poor prognosis.
DOI: 10.7284/112980
title: Meteorological Station data collected during research cruise NH1310 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423454.v2
title: Wahbeh_Additional Data for Trance Channel Study

description: This fileset contains extended data for a manuscript. It includes the online survey administered, stories read by participants, and transcripts of open-ended responses.
DOI: 10.6084/m9.figshare.7423454.v1
title: Wahbeh_Additional Data for Trance Channel Study

description: This fileset contains extended data for a manuscript. It includes the online survey administered, stories read by participants, and transcripts of open-ended responses.
DOI: 10.7284/112987
title: Meteorological Station data collected during research cruise NH1310 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112981
title: Winch data collected during research cruise NH1310 using a Markey DUSH-5 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112990
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise NH1311 using a Hawaii UHDAS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112989
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise NH1311 using a Sea-Bird SBE-911+ instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423364
title: Supplementary Material for: National Trends and Procedural Complications from Endomyocardial Biopsy: Results from the National Inpatient Sample, 2007–2014

description: <b><i>Aim:</i></b> The aim of this study is to report recent trends in the performance of endomyocardial biopsy (EMB) and its in-hospital complications (and their predictors) in the United States (US). <b><i>Method:</i></b> We analyzed Nationwide Inpatient Sample (NIS) database from years 2007 through 2014 to identify patients who underwent EMB. Once identified, the patients were subdivided into those with no history of heart transplant (HT) (cohort 1) and those with history of HT (cohort 2). We then studied the major complication of pericardial effusion, hemopericardium or/and cardiac tamponade that required a pericardiocentesis or a pericardial window (CTRPD) following the EMB procedure. <b><i>Results:</i></b> We observed a steady increase in the in-patient EMB procedures, with more EMB procedures being performed in males and in Caucasians. In cohort 1, the CTRPD was higher (0.70%) as compared to cohort 2 (0.19; <i>p</i> = 0.01). CTRPD in women was higher compared to men (0.94 vs. 0.53% <i>p</i> = 0.022). Most of the EMB procedures are performed in teaching hospitals. The CTRPD rate was significantly higher in the nonteaching hospitals when compared to teaching hospitals in both cohort 1 and cohort 2 (3.4 vs. 0.53% and 1 vs.0.18%, respectively; <i>p</i> = 0.01 and &lt; 0.001, respectively). The overall mortality in cohort 1 was 4.3% as compared to 2.5% in cohort 2; <i>p</i> = 0.01. In cohort 1, the mortality was significantly higher in the group that had EMB-related complications versus the group without the complications (20 vs. 2.5%; <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> There has been an increase in the number of EMB procedures in the US in recent years. Though the overall risk of CTRPD is very low, the risk is significantly higher in cohort 1, women, and in nonteaching hospitals. The study results provide data benchmarks for assessing EMB outcomes in the US.
DOI: 10.7284/112993
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1311 using a Furuno GP-150 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423364.v1
title: Supplementary Material for: National Trends and Procedural Complications from Endomyocardial Biopsy: Results from the National Inpatient Sample, 2007–2014

description: <b><i>Aim:</i></b> The aim of this study is to report recent trends in the performance of endomyocardial biopsy (EMB) and its in-hospital complications (and their predictors) in the United States (US). <b><i>Method:</i></b> We analyzed Nationwide Inpatient Sample (NIS) database from years 2007 through 2014 to identify patients who underwent EMB. Once identified, the patients were subdivided into those with no history of heart transplant (HT) (cohort 1) and those with history of HT (cohort 2). We then studied the major complication of pericardial effusion, hemopericardium or/and cardiac tamponade that required a pericardiocentesis or a pericardial window (CTRPD) following the EMB procedure. <b><i>Results:</i></b> We observed a steady increase in the in-patient EMB procedures, with more EMB procedures being performed in males and in Caucasians. In cohort 1, the CTRPD was higher (0.70%) as compared to cohort 2 (0.19; <i>p</i> = 0.01). CTRPD in women was higher compared to men (0.94 vs. 0.53% <i>p</i> = 0.022). Most of the EMB procedures are performed in teaching hospitals. The CTRPD rate was significantly higher in the nonteaching hospitals when compared to teaching hospitals in both cohort 1 and cohort 2 (3.4 vs. 0.53% and 1 vs.0.18%, respectively; <i>p</i> = 0.01 and &lt; 0.001, respectively). The overall mortality in cohort 1 was 4.3% as compared to 2.5% in cohort 2; <i>p</i> = 0.01. In cohort 1, the mortality was significantly higher in the group that had EMB-related complications versus the group without the complications (20 vs. 2.5%; <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> There has been an increase in the number of EMB procedures in the US in recent years. Though the overall risk of CTRPD is very low, the risk is significantly higher in cohort 1, women, and in nonteaching hospitals. The study results provide data benchmarks for assessing EMB outcomes in the US.
DOI: 10.7284/112995
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1311 using a Garmin GPS-17HVS instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112996
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1311 using a Ashtech ADU2 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112997
title: GNSS (Global Navigation Satellite System) data collected during research cruise NH1311 using a Furuno GP-90D instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112994
title: Gyrocompass data collected during research cruise NH1311 using a Sperry MK-37 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423265.v1
title: VALIDACIÓN DE UNA ESTRATEGIA DE ENSEÑANZA CON APOYO DE LA RED SOCIAL EDMODO PARA CONTRIBUIR EN EL APRENDIZAJE DE RESOLUCIÓN DE PROBLEMAS MATEMÁTICOS

description: El trabajo de investigación se realizó con el objetivo de validar la aplicación de una estrategia de enseñanza con el apoyo de la red social y la plataforma Edmodo para ayudar en la resolución de problemas matemáticos aplicados a estudiantes de primer año año de ingeniería en finanzas en el Instituto Profesional AIEP provenientes de liceos técnicos profesionales de la comuna de San Felipe. El marco teórico englobará las categorías que contribuya a la mejora de la capacidad de resolución de problemas, entre ellas se mencionan la plataforma Edmodo, la estrategia de enseñanza, la resolución de problemas y la enseñanza-aprendizaje de los estudiantes en la actualidad. La Metodología utilizada tuvo un diseño experimental. También tiene el enfoque mixto, análisis cuantitativo y análisis del discurso sociológico de la información recopilada a través de un cuestionario abierto. Los resultados de las encuestas y el cuestionario ayudaron a establecer las conclusiones y las recomendaciones, además de las propuestas con el uso de la plataforma Edmodo para la resolución de problemas en el contexto de las finanzas.<br>
DOI: 10.6084/m9.figshare.7423247
title: sst_modis_day.nc

description: MODIS sst 15-year timeseries in greater Kotzebue sound<br>
DOI: 10.6084/m9.figshare.7423247.v1
title: sst_modis_day.nc

description: MODIS sst 15-year timeseries in greater Kotzebue sound<br>
DOI: 10.7284/112991
title: Meteorological Station data collected during research cruise NH1311 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/112998
title: Meteorological Station data collected during research cruise NH1311 using a SIO MET-System instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7423163
title: Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks

description: DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is replicated only once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required for both the initiation and elongation of DNA replication. Although only two DNA helicase activities are necessary to establish a bidirectional replication fork from each replication origin, a large excess of MCM complexes is amassed and distributed along the chromatin. The function of the additional MCM complexes is not well understood, as most are displaced from the DNA during the S-phase, apparently without playing an active role in DNA replication. DNA damage response (DDR) kinases activated by stalled forks prevent the replication machinery from being activated, indicating a tight relationship between DDR and DNA replication. To investigate the role of MCM proteins in the cellular response to DNA damage, we used shRNA targeting MCM2 or MCM3 to determine the impact of a reduction in MCM complex. The alteration of MCM proteins induced a change in the activation of key factors of the DDR in response to Etoposide treatment. Etoposide-induced DNA damage affected the phosphorylation of γ-H2AX, CHK1 and CHK2 without affecting cell viability. Using assays measuring homologous recombination (HR) and non-homologous end-joining (NHEJ), we identified a decrease in both HR and NHEJ associated with a decrease in MCM complex.
DOI: 10.6084/m9.figshare.7423166
title: Divergent impact of actin isoforms on cell cycle regulation

description: We have shown that cytoplasmic actin isoforms play different roles in neoplastic cell transformation. β-Cytoplasmic actin acts as a tumor suppressor, affecting epithelial differentiation, cell growth, cell invasion and tumor growth of colon and lung carcinoma cells. In contrast, γ-cytoplasmic actin enhances malignant features of tumor cells whose actin network regulation is carried out <i>via</i> the γ-actin isoform. The goal of this study was to describe the role of cytoplasmic actins in cell cycle regulation of breast cancer cell lines MCF-7 and MDA-MB-231. The distinct roles of each cytoplasmic actin in the cell cycle driving were observed. β-Actin as well as γ-actin down-regulation inhibited proliferation of breast cancer cells, but only down-regulation of β-actin induced a significant decrease in diploid cell population and accumulation of tetraploid cells. Down-regulation of β-actin stimulated cyclin A2, B1 and D3 expression, whereas down-regulation of γ-actin reduced expression of these cyclins in both cell lines. Moreover, cyclin B1 and γ-actin were co-localized in mitotic control and β-actin-deficient cells. In mitotic MCF-7 cells down-regulation of β-actin caused an enrichment of prophase/metaphase population compared with control. γ-Actin down-regulation induced telophase enrichment. ERK1/2 and γ-actin co-localization and possible selective binding were revealed in MCF7 cells. β-Actin down-regulation induced ERK1/2 activation, while γ-actin down-regulation led to reduction of p-ERK1/2. A direct interaction of ERK1/2 with γ-actin and cyclin A2 in the same protein complex was also discovered. We suggest that γ-actin down-regulation leads to decrease of cyclin A2 level, inhibits ERK1/2 signaling and deceleration of breast cancer cells proliferation.
DOI: 10.6084/m9.figshare.7423166.v1
title: Divergent impact of actin isoforms on cell cycle regulation

description: We have shown that cytoplasmic actin isoforms play different roles in neoplastic cell transformation. β-Cytoplasmic actin acts as a tumor suppressor, affecting epithelial differentiation, cell growth, cell invasion and tumor growth of colon and lung carcinoma cells. In contrast, γ-cytoplasmic actin enhances malignant features of tumor cells whose actin network regulation is carried out <i>via</i> the γ-actin isoform. The goal of this study was to describe the role of cytoplasmic actins in cell cycle regulation of breast cancer cell lines MCF-7 and MDA-MB-231. The distinct roles of each cytoplasmic actin in the cell cycle driving were observed. β-Actin as well as γ-actin down-regulation inhibited proliferation of breast cancer cells, but only down-regulation of β-actin induced a significant decrease in diploid cell population and accumulation of tetraploid cells. Down-regulation of β-actin stimulated cyclin A2, B1 and D3 expression, whereas down-regulation of γ-actin reduced expression of these cyclins in both cell lines. Moreover, cyclin B1 and γ-actin were co-localized in mitotic control and β-actin-deficient cells. In mitotic MCF-7 cells down-regulation of β-actin caused an enrichment of prophase/metaphase population compared with control. γ-Actin down-regulation induced telophase enrichment. ERK1/2 and γ-actin co-localization and possible selective binding were revealed in MCF7 cells. β-Actin down-regulation induced ERK1/2 activation, while γ-actin down-regulation led to reduction of p-ERK1/2. A direct interaction of ERK1/2 with γ-actin and cyclin A2 in the same protein complex was also discovered. We suggest that γ-actin down-regulation leads to decrease of cyclin A2 level, inhibits ERK1/2 signaling and deceleration of breast cancer cells proliferation.
DOI: 10.6084/m9.figshare.7423157
title: Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

description: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease of unknown etiology. Multiple studies point to disruptions in immune functioning in ME/CFS patients as well as specific genetic polymorphisms and alterations of the DNA methylome in lymphocytes. However, potential interactions between DNA methylation and genetic background in relation to ME/CFS have not been examined. In this study we explored this association by characterizing the epigenetic (~480 thousand CpG loci) and genetic (~4.3 million SNPs) variation between cohorts of ME/CFS patients and healthy controls. We found significant associations of DNA methylation states in T-lymphocytes at several CpG loci and regions with ME/CFS phenotype. These methylation anomalies are in close proximity to genes involved with immune function and cellular metabolism. Finally, we found significant correlations of genotypes with methylation modifications associated with ME/CFS. The findings from this study highlight the role of epigenetic and genetic interactions in complex diseases, and suggest several genetic and epigenetic elements potentially involved in the mechanisms of disease in ME/CFS.
DOI: 10.6084/m9.figshare.7423163.v2
title: Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks

description: DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is replicated only once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required for both the initiation and elongation of DNA replication. Although only two DNA helicase activities are necessary to establish a bidirectional replication fork from each replication origin, a large excess of MCM complexes is amassed and distributed along the chromatin. The function of the additional MCM complexes is not well understood, as most are displaced from the DNA during the S-phase, apparently without playing an active role in DNA replication. DNA damage response (DDR) kinases activated by stalled forks prevent the replication machinery from being activated, indicating a tight relationship between DDR and DNA replication. To investigate the role of MCM proteins in the cellular response to DNA damage, we used shRNA targeting MCM2 or MCM3 to determine the impact of a reduction in MCM complex. The alteration of MCM proteins induced a change in the activation of key factors of the DDR in response to Etoposide treatment. Etoposide-induced DNA damage affected the phosphorylation of γ-H2AX, CHK1 and CHK2 without affecting cell viability. Using assays measuring homologous recombination (HR) and non-homologous end-joining (NHEJ), we identified a decrease in both HR and NHEJ associated with a decrease in MCM complex.
DOI: 10.7284/112992
title: Winch data collected during research cruise NH1311 using a Markey DUSH-5 instrument system onboard the platform RV New Horizon

description: Original (unprocessed) data collected during a Field_expedition