cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3830694
title: Supplementary Material for: Efficacy of Vitrectomy Combined with Subretinal Recombinant Tissue Plasminogen Activator for Subretinal versus Subpigment Epithelial versus Combined Hemorrhages

description: <b><i>Background:</i></b> The aim of this study was to compare the outcomes after subretinal recombinant tissue plasminogen activator (rtPA) treatment for subretinal hemorrhages (SRH), subpigment epithelial hemorrhages (SPH), and combined subretinal and subpigment epithelial hemorrhages (CH). <b><i>Methods:</i></b> An observational analysis of patients treated with subretinal rtPA was performed. The primary endpoint was the assessment of visual improvement (best-corrected visual acuity, BCVA) after surgery. Secondary endpoints were evaluation of the maximal hemorrhage diameter (MHD) and central macular thickness (CMT) measured by spectral domain optical coherence tomography. <b><i>Results:</i></b> From a total of 83 eyes included in the study, 19 eyes showed SRH, 11 eyes SPH, and 53 eyes CH. For SRH and CH, the mean BCVA, MHD, and CMT improved significantly (p &lt; 0.05). For patients with SPH, both the mean MHD and CMT decreased significantly (p &lt; 0.05), whereas the mean BCVA improved only slightly after surgery (p = 0.28). <b><i>Conclusion:</i></b> Vitrectomy combined with subretinal rtPA injection and gas or air tamponade has a strong functional and anatomical effect on both SRH and CH and also seems to slightly improve the anatomical outcome in SPH.
DOI: 10.7910/dvn/v1rjpf/nw70hb
title: mea20170131_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830694.v1
title: Supplementary Material for: Efficacy of Vitrectomy Combined with Subretinal Recombinant Tissue Plasminogen Activator for Subretinal versus Subpigment Epithelial versus Combined Hemorrhages

description: <b><i>Background:</i></b> The aim of this study was to compare the outcomes after subretinal recombinant tissue plasminogen activator (rtPA) treatment for subretinal hemorrhages (SRH), subpigment epithelial hemorrhages (SPH), and combined subretinal and subpigment epithelial hemorrhages (CH). <b><i>Methods:</i></b> An observational analysis of patients treated with subretinal rtPA was performed. The primary endpoint was the assessment of visual improvement (best-corrected visual acuity, BCVA) after surgery. Secondary endpoints were evaluation of the maximal hemorrhage diameter (MHD) and central macular thickness (CMT) measured by spectral domain optical coherence tomography. <b><i>Results:</i></b> From a total of 83 eyes included in the study, 19 eyes showed SRH, 11 eyes SPH, and 53 eyes CH. For SRH and CH, the mean BCVA, MHD, and CMT improved significantly (p &lt; 0.05). For patients with SPH, both the mean MHD and CMT decreased significantly (p &lt; 0.05), whereas the mean BCVA improved only slightly after surgery (p = 0.28). <b><i>Conclusion:</i></b> Vitrectomy combined with subretinal rtPA injection and gas or air tamponade has a strong functional and anatomical effect on both SRH and CH and also seems to slightly improve the anatomical outcome in SPH.
DOI: 10.7910/dvn/v1rjpf/lyg4bw
title: mea20170711_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830667
title: Supplementary Material for: Telomere Length Recovery: A Strong Predictor of Overall Survival in Acute Promyelocytic Leukemia

description: Telomeres are the capping ends of chromosomes that protect the loss of genetic material and prevent chromosomal instability. In human tissue-specific stem/progenitor cells, telomere length (TL) is maintained by the telomerase complex, which consists of a reverse transcriptase catalytic subunit (TERT) and an RNA template <i>(TERC)</i>. Very short telomeres and loss-of-function mutations in the <i>TERT</i> and <i>TERC</i> genes have been reported in acute myeloid leukemia, but the role of telomeres in acute promyelocytic leukemia (APL) has not been well established. We report the results for a large cohort of 187 PML/RARα-positive APL patients. No germline mutations in the <i>TERT</i> or <i>TERC </i>genes were identified. Codon 279 and 1062 <i>TERT</i> polymorphisms were present at a frequency similar to that in the general population. TL measured in blood or marrow mononuclear cells at diagnosis was significantly shorter in the APL patients than in healthy volunteers, and shorter telomeres at diagnosis were significantly associated with high-risk disease. For patients who achieved complete remission, the median increase in TL from diagnosis to remission (delta TL) was 2.0 kilobase (kb), and we found delta TL to be the most powerful predictor of overall survival when compared with well-established risk factors for poor outcomes in APL.
DOI: 10.6084/m9.figshare.3830667.v1
title: Supplementary Material for: Telomere Length Recovery: A Strong Predictor of Overall Survival in Acute Promyelocytic Leukemia

description: Telomeres are the capping ends of chromosomes that protect the loss of genetic material and prevent chromosomal instability. In human tissue-specific stem/progenitor cells, telomere length (TL) is maintained by the telomerase complex, which consists of a reverse transcriptase catalytic subunit (TERT) and an RNA template <i>(TERC)</i>. Very short telomeres and loss-of-function mutations in the <i>TERT</i> and <i>TERC</i> genes have been reported in acute myeloid leukemia, but the role of telomeres in acute promyelocytic leukemia (APL) has not been well established. We report the results for a large cohort of 187 PML/RARα-positive APL patients. No germline mutations in the <i>TERT</i> or <i>TERC </i>genes were identified. Codon 279 and 1062 <i>TERT</i> polymorphisms were present at a frequency similar to that in the general population. TL measured in blood or marrow mononuclear cells at diagnosis was significantly shorter in the APL patients than in healthy volunteers, and shorter telomeres at diagnosis were significantly associated with high-risk disease. For patients who achieved complete remission, the median increase in TL from diagnosis to remission (delta TL) was 2.0 kilobase (kb), and we found delta TL to be the most powerful predictor of overall survival when compared with well-established risk factors for poor outcomes in APL.
DOI: 10.7910/dvn/v1rjpf/jnwxht
title: mea20170319_03.txt.gz

description: :unav
DOI: 10.5281/zenodo.4013858
title: Ooh Na Na Alternative Identifiers

description: A dump of the alternative identifiers extracted from the OBO Foundry as a three column TSV - prefixes, alt identifiers, primary identifiers.
DOI: 10.6084/m9.figshare.3830637
title: Supplementary Material for: Evidence of Interruption of the comM Gene in a Large Series of Clinical Isolates of Multidrug-Resistant Acinetobacter baumannii

description: Recent studies have recognized the ATPase-encoding <i>comM</i> gene as a hot spot for the integration of <i>Acinetobacter baumannii</i> resistance islands (RIs). Despite the circulation of high numbers of multidrug-resistant <i>A. baumannii </i>(MDR-AB) isolates in Middle East countries, no information is available about the interruption of <i>comM</i> and subsequent transposition into <i>comM</i> in isolates belonging to the global clones (GC) GC1, GC2, or GC3. In this study 401 <i>A. baumannii</i> isolates from hospitals in Tehran, Iran, were included. The resistance profile was determined by disc diffusion against 22 antibiotics. PCR was used to assess the GC type, presence of the <i>comM</i> gene, and the boundary junctions (J1 and J2) of RIs. Most of the MDR-AB isolates (384 of 388; 98%) and more than half of the susceptible <i>A. baumannii </i>isolates (9 of 13; 69%) had interrupted <i>comM</i> gene-carrying integrative elements. Among the isolates tested, 57 belonged to GC1, 86 to GC2, and 8 to GC3. A set of 250 isolates showed distinct patterns of allele-specific PCR for <i>ompA</i>, <i>csuE</i>, and <i>bla</i><sub>OXA-51-like</sub> genes. All but 2 of the GC1 isolates and 2 of the GC2 isolates contained interrupted <i>comM</i> genes. Four <i>A. baumannii</i> isolates harbored intact <i>comM</i>, but were multiply resistant to antibiotics. This study demonstrated that the <i>comM</i> gene is targeted by transposons in Iranian MDR-AB isolates belonging to different GCs. The data also showed that the carriage of interrupted <i>comM</i> is not exclusive to MDR isolates of <i>A. baumannii</i>.
DOI: 10.7910/dvn/v1rjpf/4u8jnd
title: mea20171009_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830637.v1
title: Supplementary Material for: Evidence of Interruption of the comM Gene in a Large Series of Clinical Isolates of Multidrug-Resistant Acinetobacter baumannii

description: Recent studies have recognized the ATPase-encoding <i>comM</i> gene as a hot spot for the integration of <i>Acinetobacter baumannii</i> resistance islands (RIs). Despite the circulation of high numbers of multidrug-resistant <i>A. baumannii </i>(MDR-AB) isolates in Middle East countries, no information is available about the interruption of <i>comM</i> and subsequent transposition into <i>comM</i> in isolates belonging to the global clones (GC) GC1, GC2, or GC3. In this study 401 <i>A. baumannii</i> isolates from hospitals in Tehran, Iran, were included. The resistance profile was determined by disc diffusion against 22 antibiotics. PCR was used to assess the GC type, presence of the <i>comM</i> gene, and the boundary junctions (J1 and J2) of RIs. Most of the MDR-AB isolates (384 of 388; 98%) and more than half of the susceptible <i>A. baumannii </i>isolates (9 of 13; 69%) had interrupted <i>comM</i> gene-carrying integrative elements. Among the isolates tested, 57 belonged to GC1, 86 to GC2, and 8 to GC3. A set of 250 isolates showed distinct patterns of allele-specific PCR for <i>ompA</i>, <i>csuE</i>, and <i>bla</i><sub>OXA-51-like</sub> genes. All but 2 of the GC1 isolates and 2 of the GC2 isolates contained interrupted <i>comM</i> genes. Four <i>A. baumannii</i> isolates harbored intact <i>comM</i>, but were multiply resistant to antibiotics. This study demonstrated that the <i>comM</i> gene is targeted by transposons in Iranian MDR-AB isolates belonging to different GCs. The data also showed that the carriage of interrupted <i>comM</i> is not exclusive to MDR isolates of <i>A. baumannii</i>.
DOI: 10.7910/dvn/v1rjpf/dudikz
title: mea20170704_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830565
title: Supplementary Material for: The Pioneering and Unknown Stereotactic Approach of Roeder and Orthner from Göttingen. Part I. Surgical Technique for Tailoring Individualized Stereotactic Lesions

description: During the 1950s through the 1970s, Hans Orthner and Fritz Roeder, two German neurologists from Göttingen, developed a sophisticated technique to perform functional stereotactic surgery with outstanding accuracy. They introduced direct air ventriculography performed in the same surgical session as the ablative stereotactic procedure. For individualized surgical targeting, Orthner prepared a stereotactic atlas (&gt;60 brains) with an ingenious brain-slicing device, the Göttinger macrotome. Brains were grouped based on similarity of six different head and ventricle measurements. A brain cluster representing the best match for a patient was selected for stereotactic targeting. Stereotactic lesions were tailored in an individual manner and shaped by stringing together multiple small coagulations following intraoperative test stimulation. This was achieved from a single probe trajectory by using well-engineered string electrodes with calibrated curving and involved laborious calculations. Only high-frequency thermocoagulation was regarded as appropriate for lesioning. With this meticulous technique, the most advanced stereotactic procedures were performed, including bilateral pallidotomy that ultimately could be restricted to the ansa lenticularis and ventromedial hypothalamotomy, the most delicate stereotactic operation performed to date. Outside Göttingen, this technique has only been used by Prof. Dieter Müller in Hamburg, Germany. This elaborate stereotactic approach is widely unknown and deserves to be discussed in a historical context.
DOI: 10.7910/dvn/v1rjpf/xmyndz
title: mea20170930_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830565.v1
title: Supplementary Material for: The Pioneering and Unknown Stereotactic Approach of Roeder and Orthner from Göttingen. Part I. Surgical Technique for Tailoring Individualized Stereotactic Lesions

description: During the 1950s through the 1970s, Hans Orthner and Fritz Roeder, two German neurologists from Göttingen, developed a sophisticated technique to perform functional stereotactic surgery with outstanding accuracy. They introduced direct air ventriculography performed in the same surgical session as the ablative stereotactic procedure. For individualized surgical targeting, Orthner prepared a stereotactic atlas (&gt;60 brains) with an ingenious brain-slicing device, the Göttinger macrotome. Brains were grouped based on similarity of six different head and ventricle measurements. A brain cluster representing the best match for a patient was selected for stereotactic targeting. Stereotactic lesions were tailored in an individual manner and shaped by stringing together multiple small coagulations following intraoperative test stimulation. This was achieved from a single probe trajectory by using well-engineered string electrodes with calibrated curving and involved laborious calculations. Only high-frequency thermocoagulation was regarded as appropriate for lesioning. With this meticulous technique, the most advanced stereotactic procedures were performed, including bilateral pallidotomy that ultimately could be restricted to the ansa lenticularis and ventromedial hypothalamotomy, the most delicate stereotactic operation performed to date. Outside Göttingen, this technique has only been used by Prof. Dieter Müller in Hamburg, Germany. This elaborate stereotactic approach is widely unknown and deserves to be discussed in a historical context.
DOI: 10.7910/dvn/v1rjpf/ol4kmu
title: mea20170613_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830556
title: Steroids contents in waters of wastewater purification plants: determination with partial-filling micellar electrokinetic capillary chromatography and UV detection

description: Partial-filling micellar electrokinetic capillary chromatography (PF-MEKC) with UV detection was applied for determination of human-based steroids in water samples of Finnish wastewater treatment plants. The samples were purified with solid-phase extraction (SPE) on octadecyl substituted polymer sorbents obtaining analyte enrichment of 20,000-fold. The steroids studied were androgens, estrogens, and progesterone. Three of the steroids could be quantified with the PF-MEKC method. The detection and quantification limits were 0.05–1.06 μg/mL and 0.15–3.2 μg/mL, meaning in the SPE concentrates as 2.5–53 pg/L and 7.5–160 pg/L, respectively. In the influent waters, the total amount of testosterone glucuronide, androstenedione, and progesterone was up to 350 ng/L. In effluent water samples the total steroid quantity was maximum at 320 ng/L. Remarkably high quantity of androstenedione was quantified in both influent and effluent water samples. The cleanest effluent waters were produced in Western Finland. Correspondingly, the highest quantities were located near the largest lake and river areas in South-Eastern Finland. The concentration variation in effluent waters was explained with differences in the purification materials and processes at the plants and with steroid adsorption on soil and organic material suspended into water.
DOI: 10.6084/m9.figshare.3830556.v1
title: Steroids contents in waters of wastewater purification plants: determination with partial-filling micellar electrokinetic capillary chromatography and UV detection

description: Partial-filling micellar electrokinetic capillary chromatography (PF-MEKC) with UV detection was applied for determination of human-based steroids in water samples of Finnish wastewater treatment plants. The samples were purified with solid-phase extraction (SPE) on octadecyl substituted polymer sorbents obtaining analyte enrichment of 20,000-fold. The steroids studied were androgens, estrogens, and progesterone. Three of the steroids could be quantified with the PF-MEKC method. The detection and quantification limits were 0.05–1.06 μg/mL and 0.15–3.2 μg/mL, meaning in the SPE concentrates as 2.5–53 pg/L and 7.5–160 pg/L, respectively. In the influent waters, the total amount of testosterone glucuronide, androstenedione, and progesterone was up to 350 ng/L. In effluent water samples the total steroid quantity was maximum at 320 ng/L. Remarkably high quantity of androstenedione was quantified in both influent and effluent water samples. The cleanest effluent waters were produced in Western Finland. Correspondingly, the highest quantities were located near the largest lake and river areas in South-Eastern Finland. The concentration variation in effluent waters was explained with differences in the purification materials and processes at the plants and with steroid adsorption on soil and organic material suspended into water.
DOI: 10.7910/dvn/v1rjpf/0dwo7s
title: mea20170102_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3als2i
title: mea20170327_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/10ndwl
title: mea20170301_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/xfvtct
title: mea20171117_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/6n9zls
title: mea20171014_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/agmd5i
title: mea20170513_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/morb08
title: mea20170514_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830508
title: Additional Info.

description: Additional information
DOI: 10.6084/m9.figshare.3830508.v1
title: Additional Info.

description: Additional information
DOI: 10.7910/dvn/v1rjpf/dc8dxn
title: mea20170808_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830496
title: Pleistocene age paleo-groundwater inferred from water-stable isotope values in the central part of the Baltic Artesian Basin

description: A new data set of δ<sup>2</sup>H and δ<sup>18</sup>O in the groundwater from the central part of the Baltic Artesian Basin is presented. The hydrogeological section is subdivided into stagnation, slow exchange and active exchange zones. Na–Ca–Cl brine found at the deepest part – the stagnation zone – is characterized by δ<sup>18</sup>O values above −5 ‰ and δ<sup>2</sup>H values approaching −40 ‰ with respect to Vienna Standard Mean Ocean Water. The slow exchange zone where waters of mostly intermediate salinity reside is characterized by δ<sup>18</sup>O values around −11.7 ‰ and δ<sup>2</sup>H values around −85.3 ‰. Mean δ<sup>18</sup>O and δ<sup>2</sup>H values of the fresh groundwater in the active water exchange zone are −11.1 and −79.9 ‰, respectively. Characteristically, the groundwater in the active and slow exchange zone is isotopically more depleted compared with the precipitation values observed, and the depletion increases with depth down to the level where strongly enriched brines are encountered.
DOI: 10.6084/m9.figshare.3830496.v1
title: Pleistocene age paleo-groundwater inferred from water-stable isotope values in the central part of the Baltic Artesian Basin

description: A new data set of δ<sup>2</sup>H and δ<sup>18</sup>O in the groundwater from the central part of the Baltic Artesian Basin is presented. The hydrogeological section is subdivided into stagnation, slow exchange and active exchange zones. Na–Ca–Cl brine found at the deepest part – the stagnation zone – is characterized by δ<sup>18</sup>O values above −5 ‰ and δ<sup>2</sup>H values approaching −40 ‰ with respect to Vienna Standard Mean Ocean Water. The slow exchange zone where waters of mostly intermediate salinity reside is characterized by δ<sup>18</sup>O values around −11.7 ‰ and δ<sup>2</sup>H values around −85.3 ‰. Mean δ<sup>18</sup>O and δ<sup>2</sup>H values of the fresh groundwater in the active water exchange zone are −11.1 and −79.9 ‰, respectively. Characteristically, the groundwater in the active and slow exchange zone is isotopically more depleted compared with the precipitation values observed, and the depletion increases with depth down to the level where strongly enriched brines are encountered.
DOI: 10.7910/dvn/v1rjpf/bhcyku
title: mea20170216_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830448
title: The tectonomagmatic significance of Neoarchaean variably alkali-enriched gabbro and diorite intrusions of the western Karelia Province

description: Table detailing oxygen-isotope analyses from this study.
DOI: 10.6084/m9.figshare.3830448.v1
title: The tectonomagmatic significance of Neoarchaean variably alkali-enriched gabbro and diorite intrusions of the western Karelia Province

description: Table detailing oxygen-isotope analyses from this study.
DOI: 10.7910/dvn/v1rjpf/ii0agd
title: mea20170221_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830439
title: The cost-effectiveness of TheraBite® as treatment for acute myogenic temporomandibular disorder

description: <b>Objective:</b> Temporomandibular disorder (TMD) is a very common and costly pain problem concerning the temporomandibular joint. A previous study has shown that for the treatment of acute myogenic TMD, TheraBite® (TB) offers a faster and greater effect than usual care consisting of physical therapy (PT). This study estimates the cost-effectiveness of TB compared to PT. <b>Methods:</b> Differences in costs and quality-adjusted life-years (QALYs) between TB and PT are analyzed using a decision model. <b>Results:</b> The point estimate for the incremental cost-effectiveness ratio is −28,068 EUR (−30,191 USD) per QALY (dominant) for TB versus PT. At the willingness-to-pay ratio of 20,000 EUR (21,513 USD) per QALY, TB has a 97% probability of being cost-effective compared to PT. <b>Conclusion:</b> TB is expected to be cost-effective compared to PT for the treatment of acute myogenic TMD, offering faster recovery of quality of life for patients, at a lower cost to society.
DOI: 10.7910/dvn/v1rjpf/uuescp
title: mea20171127_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830439.v1
title: The cost-effectiveness of TheraBite® as treatment for acute myogenic temporomandibular disorder

description: <b>Objective:</b> Temporomandibular disorder (TMD) is a very common and costly pain problem concerning the temporomandibular joint. A previous study has shown that for the treatment of acute myogenic TMD, TheraBite® (TB) offers a faster and greater effect than usual care consisting of physical therapy (PT). This study estimates the cost-effectiveness of TB compared to PT. <b>Methods:</b> Differences in costs and quality-adjusted life-years (QALYs) between TB and PT are analyzed using a decision model. <b>Results:</b> The point estimate for the incremental cost-effectiveness ratio is −28,068 EUR (−30,191 USD) per QALY (dominant) for TB versus PT. At the willingness-to-pay ratio of 20,000 EUR (21,513 USD) per QALY, TB has a 97% probability of being cost-effective compared to PT. <b>Conclusion:</b> TB is expected to be cost-effective compared to PT for the treatment of acute myogenic TMD, offering faster recovery of quality of life for patients, at a lower cost to society.
DOI: 10.7910/dvn/v1rjpf/vjbyj7
title: mea20171015_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/4s30a1
title: mea20171116_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830388
title: Nature Salary and Job satisfaction survey

description: Raw data for Nature's 2016 salary and job satisfaction survey
DOI: 10.7910/dvn/v1rjpf/02v6za
title: mea20170129_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830376
title: University of Leeds RCUK Report Aug 2015-July 2016.xlsx

description: University of Leeds RCUK Report August 2015 - July 2016
DOI: 10.7910/dvn/v1rjpf/vazxb0
title: mea20170701_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3830376.v1
title: University of Leeds RCUK Report Aug 2015-July 2016.xlsx

description: University of Leeds RCUK Report August 2015 - July 2016