cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16998975.v1
title: MicroRNA-29a May Influence Myopia Development by Regulating Collagen I

description: The aim of this study was to characterize the regulatory role of microRNA-29a (miR-29a) in myopia, providing support for potential biomarkers and new therapeutic targets of myopia in humans. The miR-29a expression level was detected in the aqueous humor and peripheral blood plasma of 21 high myopic patients and eight cataract control patients using quantitative polymerase chain reaction. iTRAQ analysis of proteomes was conducted to show the regulatory effect of miR-29a on human scleral fibroblasts (SFs) cultured <i>in vitro</i>. We also assessed proliferation, migration, and collagen I synthesis in SF cells, mediated by miR-29a. MiR-29a expression was significantly higher in the aqueous humor of highly myopic patients than in the cataract control patients (fold change: 4.861, p = 0.001). miR-29a inhibited the synthesis of type I collagen in human SF cells and enhanced cell migration, but had no significant effect on cell proliferation. MiR-29a was highly expressed in aqueous humor of myopia patients and inhibited the synthesis of type I collagen in human SF cells <i>in vivo</i>, thereby it may play an important role in myopia development.
DOI: 10.6084/m9.figshare.19092565.v1
title: Additional file 15 of An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

description: Additional file 15: Table S5. The detailed information of 3585 LLPS-related genes in homo sapiens.
DOI: 10.6084/m9.figshare.7558310.v1
title: Additional file 3: of Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia

description: Results detail of CLL sex-related DMPs, DMRs, DEGs, GO, and FEM. (XLSX 4427 kb)
DOI: 10.6084/m9.figshare.12276779
title: Additional file 5 of The loss of photosynthesis pathway and genomic locations of the lost plastid genes in a holoparasitic plant Aeginetia indica

description: Additional file 5: Table S1. Gene contents of the plastomes of five holoparasitic plants and one autotrophic relative Lindenbergia philippensisin. Black boxes indicate the absence of genes, white boxes indicate the presence of genes, and gray boxes indicate pseudogenes.
DOI: 10.6084/m9.figshare.12276785.v1
title: Additional file 6 of The loss of photosynthesis pathway and genomic locations of the lost plastid genes in a holoparasitic plant Aeginetia indica

description: Additional file 6: Table S2. Genomic locations of the lost and transferred plastid genes in Aeginetia indica. The annotation, sequence alignment, alignment position and sequence identity are all based on the chloroplast genes of Lindenbergia philippensis. * indicates gene also present in the plastome of Aeginetia indica.
DOI: 10.6084/m9.figshare.12276764
title: Additional file 10 of The loss of photosynthesis pathway and genomic locations of the lost plastid genes in a holoparasitic plant Aeginetia indica

description: Additional file 10: Table S6. Primers used for quantitative real-time PCR.
DOI: 10.6084/m9.figshare.7033925.v1
title: Additional file 1: of Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

description: Table S1. Primer sequences used for mutation reconstruction and RM-seq. Table S2. Whole genome sequencing and SNP/indel calling of reconstructed rpoB mutants. Table S3. Rifampicin and daptomycin MIC of reconstructed mutants. Table S4. Characteristics of RM-seq sequencing libraries. (XLSX 34 kb)
DOI: 10.6084/m9.figshare.12276764.v1
title: Additional file 10 of The loss of photosynthesis pathway and genomic locations of the lost plastid genes in a holoparasitic plant Aeginetia indica

description: Additional file 10: Table S6. Primers used for quantitative real-time PCR.
DOI: 10.6084/m9.figshare.19092568
title: Additional file 16 of An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

description: Additional file 16: Table S6. The LLPS-related DEGs between LGG samples and normal samples.
DOI: 10.6084/m9.figshare.19092571
title: Additional file 17 of An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

description: Additional file 17: Table S7. The prognostic LLPS-related genes obtained through univariate Cox regression analysis in TCGA cohort.
DOI: 10.6084/m9.figshare.19092571.v1
title: Additional file 17 of An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

description: Additional file 17: Table S7. The prognostic LLPS-related genes obtained through univariate Cox regression analysis in TCGA cohort.
DOI: 10.6084/m9.figshare.19090820
title: Additional file 1 of Identification of novel signaling components in N,N’-Dinitrosopiperazine-mediated metastasis of nasopharyngeal Carcinoma by quantitative phosphoproteomics

description: Additional file 1: Table S1: DNP-regulated phosphopeptides identified using a SILAC quantitative proteomics approach. (XLS 212 KB)
DOI: 10.6084/m9.figshare.19092565
title: Additional file 15 of An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

description: Additional file 15: Table S5. The detailed information of 3585 LLPS-related genes in homo sapiens.
DOI: 10.6084/m9.figshare.19092660.v1
title: Additional file 1 of Differences in caecal microbiota composition and Salmonella carriage between experimentally infected inbred lines of chickens

description: Additional file 1. Feed composition used, primers sequences used for the amplification of the region specific to Salmonella Enteritidis in the invA gene and adapter/primer used in Illumina amplicon library preparation.
DOI: 10.6084/m9.figshare.19092669.v1
title: Additional file 4 of Differences in caecal microbiota composition and Salmonella carriage between experimentally infected inbred lines of chickens

description: Additional file 4. Taxonomic assignments for operational taxonomic units.
DOI: 10.6084/m9.figshare.13323728
title: Additional file 11 of Transcriptomic profiles of non-embryogenic and embryogenic callus cells in a highly regenerative upland cotton line (Gossypium hirsutum L.)

description: Additional file 11. Genes involved in DNA methylation regulation in NEC and EC callus. A list of all annotated genes involved in methylation regulation in the v2.0 of Gossypium hirsutum reference assembly with logFC values in EC. Functional annotation from domain scan and Arabidopsis thaliana definition lines from the best hit.
DOI: 10.6084/m9.figshare.19092669
title: Additional file 4 of Differences in caecal microbiota composition and Salmonella carriage between experimentally infected inbred lines of chickens

description: Additional file 4. Taxonomic assignments for operational taxonomic units.
DOI: 10.6084/m9.figshare.6509762
title: Geochronology, geochemistry and Sr-Nd-Pb-Hf isotopes of the Early Paleogene gabbro and granite from Central Lhasa, southern Tibet: petrogenesis and tectonic implications

description: The Tibetan Plateau is a composite orogenic belt that has experienced prolonged subduction, obduction, and collisional processes, during the opening and closure of successive Tethyan oceans. We present new zircon U-Pb ages and Hf isotopes, and whole-rock geochemical and Sr-Nd-Pb isotopic data from the Early Paleogene Longge’er gabbro and Qingduxiang granite of Central Lhasa, southern Tibet. Together these allow us to refine existing models for widespread magmatic activity associated with the subduction of the Neo-Tethyan Ocean. The Longge’er gabbro (53.5 ± 1.6 Ma) belongs to the low-K tholeiitic to medium-K and metaluminous series, while the Qingduxiang granite (54.5 ± 0.9 Ma) is characterized as high-K, calc-alkaline, metaluminous, and of I-type affinity. Both intrusions are enriched in the LREE and depleted in the HREE with negative Eu, Ba, Nb, Ta, Sr, and Ti anomalies. Trace elements characteristics and enriched whole-rock Sr-Nd-Pb and zircon Hf isotopic compositions demonstrate that the gabbro was derived from partial melting of enriched lithosphere mantle metasomatized by Central-Lhasa ancient crustal materials, while the I-type granite was generated by partial melting of Central-Lhasa ancient lower crust combined with magmas derived from Southern-Lhasa juvenile crust. Geochemical compositions of the gabbro and granite reveal the Early Paleogene magmatism was emplaced in a shallow extensional setting related to slab break off following the closure of the Neo-Tethyan Ocean. Combined with previous studies, we can infer slab rollback occurred from Late Cretaceous (~69 Ma) to Early Eocene (55 Ma), while slab break off was shortly lived at ca. 55–49 Ma. Consequently, the India-Asia collision must not have started later than ca. 55 Ma.
DOI: 10.6084/m9.figshare.19096324
title: Mesozoic tectonic transition of the northeastern North China Craton: Evidence from adakitic rocks in southeastern Jilin Province, China

description: Chronological and geochemical studies of adakites and adakitic rocks are important in understanding the tectonic evolution and geodynamic processes. We present new zircon U–Pb ages, Hf isotope, and geochemical analyses of adakitic rocks exposed in the Baishan area, southeastern Jilin Province, China. These new ages, together with existing age data, indicate that adakitic magmatism in southeastern Jilin Province can be subdivided into four stages: Early–Middle Triassic (251–235 Ma), Late Triassic (221–219 Ma), late Early–early Late Jurassic (176–156 Ma), and Early Cretaceous (ca. 130 Ma). Early–Middle Triassic adakitic rocks occur in a nearly E–W-trending belt within the northern margin of the northeastern North China Craton, indicating a compressional tectonic setting caused by the scissor-like closure of the Paleo-Asian Ocean from west to east. Late Triassic adakitic rocks occur in the Tonghua area and formed in an extensional setting caused by delamination after subduction and collision between the Yangtze Craton and NCC. Late Early–early Late Jurassic adakitic rocks occur in the Baishan and Kaiyuan areas and originated from partial melting of thickened lower crust in a compressional setting related to subduction of the Paleo-Pacific Plate. Early Cretaceous adakitic rocks occur in the Baishan area and were derived from partial melting of thickened lower crust above the subduction zone and delaminated lower crust, indicating that the subducting Paleo-Pacific Plate retreated to the eastern part of southern Jilin Province during the Early Cretaceous (ca. 130 Ma) and that the tectonic setting of the northeastern part of the NCC changed from compression to extension, starting in the east and progressing westward. In summary, the northeastern part of the NCC has been affected by a series of tectonic events during the Mesozoic, such as the closure of the Paleo-Asian Ocean, the collision between the NCC and YC, and the subduction of the Paleo-Pacific Plate.
DOI: 10.6084/m9.figshare.19092520.v1
title: Additional file 1 of Using the hybrid EMD-BPNN model to predict the incidence of HIV in Dalian, Liaoning Province, China, 2004–2018

description: Additional file 1: Monthly cases of HIV in Dalian, Liaoning province, China, during 2019 to 2020.
DOI: 10.6084/m9.figshare.11611038
title: MOESM8 of Genome-wide association reveals genetic variation of lint yield components under salty field conditions in cotton (Gossypium hirsutum L.)

description: Additional file 8 Table S6. QTNs and QTLs of single boll weight, lint percentage and boll number per plant detected by multi-loci MLM model. (XLSX 151â€‰kb)
DOI: 10.6084/m9.figshare.11611038.v1
title: MOESM8 of Genome-wide association reveals genetic variation of lint yield components under salty field conditions in cotton (Gossypium hirsutum L.)

description: Additional file 8 Table S6. QTNs and QTLs of single boll weight, lint percentage and boll number per plant detected by multi-loci MLM model. (XLSX 151â€‰kb)
DOI: 10.6084/m9.figshare.19092520
title: Additional file 1 of Using the hybrid EMD-BPNN model to predict the incidence of HIV in Dalian, Liaoning Province, China, 2004–2018

description: Additional file 1: Monthly cases of HIV in Dalian, Liaoning province, China, during 2019 to 2020.
DOI: 10.6084/m9.figshare.12276809
title: Additional file 9 of The loss of photosynthesis pathway and genomic locations of the lost plastid genes in a holoparasitic plant Aeginetia indica

description: Additional file 9: Table S5. Data sources of 64 reference plastid genomes used in this study.
DOI: 10.6084/m9.figshare.7034009.v1
title: MOESM3 of Molecular analysis of inherited cardiomyopathy using next generation semiconductor sequencing technologies

description: Additional file 3: Table S2. List of variant annotation information.
DOI: 10.6084/m9.figshare.12276809.v1
title: Additional file 9 of The loss of photosynthesis pathway and genomic locations of the lost plastid genes in a holoparasitic plant Aeginetia indica

description: Additional file 9: Table S5. Data sources of 64 reference plastid genomes used in this study.
DOI: 10.6084/m9.figshare.13323644
title: Additional file 2 of HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer

description: Additional file 2.
DOI: 10.6084/m9.figshare.13323644.v1
title: Additional file 2 of HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer

description: Additional file 2.
DOI: 10.6084/m9.figshare.13323706.v1
title: Additional file 2 of Distinct nucleotide patterns among three subgenomes of bread wheat and their potential origins during domestication after allopolyploidization

description: Additional file 2: Table S1. The comparison of [AT] values across ploymorphic sites among bread wheat and its wild progenitors. Table S2. Expression of candidate genes within qATD-3A and qATD-7D.
DOI: 10.6084/m9.figshare.7558286
title: Additional file 2: of Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

description: Table S1. Table indicating with which public dataset each sample is associated. Table S2. Differentially expressed genes between long-term treated and pre-treatment dormant tumours. Table S3. Enriched pathways for differentially expressed genes between long-term treated and pre-treatment dormant tumours. Table S4. Differentially expressed genes between long-term treated and pre-treatment acquired resistant tumours. Table S5. Enriched pathways for differentially expressed genes between long-term treated and pre-treatment acquired resistant tumours. Table S6. Differentially expressed genes between long-term treated dormant and resistant tumours. Table S7. Enriched pathways for differentially expressed genes between long-term treated dormant and resistant tumours. Table S8. Differentially expressed proteins between long-term treated dormant and resistant tumours. (XLSX 286 kb)
DOI: 10.6084/m9.figshare.13323728.v1
title: Additional file 11 of Transcriptomic profiles of non-embryogenic and embryogenic callus cells in a highly regenerative upland cotton line (Gossypium hirsutum L.)

description: Additional file 11. Genes involved in DNA methylation regulation in NEC and EC callus. A list of all annotated genes involved in methylation regulation in the v2.0 of Gossypium hirsutum reference assembly with logFC values in EC. Functional annotation from domain scan and Arabidopsis thaliana definition lines from the best hit.
DOI: 10.6084/m9.figshare.19092672.v1
title: Additional file 5 of Differences in caecal microbiota composition and Salmonella carriage between experimentally infected inbred lines of chickens

description: Additional file 5: Table S1. Results of the Anova test on individual Salmonella carriage for line, sex and experiment. Table S2. Proportion of phylum and family types over the 228 caecal microbiota analysed. Table S3. Results of the Anova test on alpha diversity and beta diversity for line, sex, experiment and high- and low-carriers. Table S4. Results of the Permanova on Bray–Curtis distance for experiment, isolators, sex and line. Table S5. Differentially abundant operational taxonomic units (DA OTU) between the N and 6l lines over the two experiments, when adjusting for isolator effect. Table S6. Differentially abundant genera and families between the N and 6l lines over the two experiments, when adjusting for isolator effect. Table S7. Differentially abundant operational taxonomic units (DA OTU) between the high and low carriers (line 6l-Experiment 1), when adjusting for isolator effect. Table S8. Differentially abundant genera and families between high and low carriers (line 6l-Experiment 1) when adjusting for isolator effect. Table S9. Differentially abundant pathways in common for the comparisons between lines N and 61 and between high and low carriers from line 6l in Experiment 1.
DOI: 10.6084/m9.figshare.7558310
title: Additional file 3: of Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia

description: Results detail of CLL sex-related DMPs, DMRs, DEGs, GO, and FEM. (XLSX 4427 kb)
DOI: 10.6084/m9.figshare.12799449
title: Additional file 6 of Development and evaluation of an up-converting phosphor technology-based lateral flow assay for rapid and quantitative detection of Coxiella burnetii phase I strains

description: Additional file 6: Table S1. The T/C ratios of UPT-LF and the C. burnetii gene copies for organ suspensions of infected mice.
DOI: 10.6084/m9.figshare.11756649
title: How Social Support Motivates Trust and Purchase Intentions in Mobile Social Commerce

description: Abstract Purpose: This study refers to the social support and trust theories to explore what kind of factors affect the users’ intention to adopt MSC. Design/methodology/approach: A total of 207 subjects who had previously experienced or known about MSC were identified and partial least squares were performed to analyse the measurement and structural models. Findings: The results indicated that MSC purchase intentions are affected significantly by four other factors (social support, perceived usefulness, subjective norm, and trust) and trust, in turn, is affected by three factors (social support, perceived usefulness, and subjective norms). Originality/value: First, this study examines the mechanism of trust formation and actions in the MSC context. Second, this study contributes by confirming the important role of social factors in the MSC context. Third, the study expands the social support theory. Finally, our research provides empirical evidence for enterprises that have adopted MSC to support their marketing strategy and programmes.
DOI: 10.6084/m9.figshare.11756649.v1
title: How Social Support Motivates Trust and Purchase Intentions in Mobile Social Commerce

description: Abstract Purpose: This study refers to the social support and trust theories to explore what kind of factors affect the users’ intention to adopt MSC. Design/methodology/approach: A total of 207 subjects who had previously experienced or known about MSC were identified and partial least squares were performed to analyse the measurement and structural models. Findings: The results indicated that MSC purchase intentions are affected significantly by four other factors (social support, perceived usefulness, subjective norm, and trust) and trust, in turn, is affected by three factors (social support, perceived usefulness, and subjective norms). Originality/value: First, this study examines the mechanism of trust formation and actions in the MSC context. Second, this study contributes by confirming the important role of social factors in the MSC context. Third, the study expands the social support theory. Finally, our research provides empirical evidence for enterprises that have adopted MSC to support their marketing strategy and programmes.
DOI: 10.6084/m9.figshare.11756766
title: miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway

description: Reperfusion strategies in acute myocardial infarction (AMI) can cause a series of additional clinical damage, defined as myocardial ischemia/reperfusion (I/R) injury, and thus there is a need for effective therapeutic methods to attenuate I/R injury. miR-26a-5p has been proven to be an essential regulator for biological processes in different cell types. Nevertheless, the role of miR-26a-5p in myocardial I/R injury has not yet been reported. We established an I/R injury model in vitro and in vivo. In vitro, we used cardiomyocytes to simulate I/R injury using hypoxia/reoxygenation (H/R) assay. In vivo, we used C57BL/6 mice to construct I/R injury model. The infarct area was examined by TTC staining. The level of miR-26a-5p and PTEN was determined by bioinformatics methods, qRT-PCR, and western blot. In addition, the viability and apoptosis of cardiomyocytes were separately detected by MTT and flow cytometry. The targeting relationship between miR-26a-5p and PTEN was analyzed by the TargetScan website and luciferase reporter assay. I/R and H/R treatment induced myocardial tissue injury and cardiomyocyte apoptosis, respectively. The results showed that miR-26a-5p was down-regulated in myocardial I/R injury. PTEN was found to be a direct target of miR-26a-5p. Furthermore, miR-26a-5p effectively improved viability and inhibited apoptosis in cardiomyocytes upon I/R injury by inhibiting PTEN expression to activate the PI3K/AKT signaling pathway. miR-26a-5p could protect cardiomyocytes against I/R injury by regulating the PTEN/PI3K/AKT pathway, which offers a potential approach for myocardial I/R injury treatment.
DOI: 10.6084/m9.figshare.11756766.v1
title: miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway

description: Reperfusion strategies in acute myocardial infarction (AMI) can cause a series of additional clinical damage, defined as myocardial ischemia/reperfusion (I/R) injury, and thus there is a need for effective therapeutic methods to attenuate I/R injury. miR-26a-5p has been proven to be an essential regulator for biological processes in different cell types. Nevertheless, the role of miR-26a-5p in myocardial I/R injury has not yet been reported. We established an I/R injury model in vitro and in vivo. In vitro, we used cardiomyocytes to simulate I/R injury using hypoxia/reoxygenation (H/R) assay. In vivo, we used C57BL/6 mice to construct I/R injury model. The infarct area was examined by TTC staining. The level of miR-26a-5p and PTEN was determined by bioinformatics methods, qRT-PCR, and western blot. In addition, the viability and apoptosis of cardiomyocytes were separately detected by MTT and flow cytometry. The targeting relationship between miR-26a-5p and PTEN was analyzed by the TargetScan website and luciferase reporter assay. I/R and H/R treatment induced myocardial tissue injury and cardiomyocyte apoptosis, respectively. The results showed that miR-26a-5p was down-regulated in myocardial I/R injury. PTEN was found to be a direct target of miR-26a-5p. Furthermore, miR-26a-5p effectively improved viability and inhibited apoptosis in cardiomyocytes upon I/R injury by inhibiting PTEN expression to activate the PI3K/AKT signaling pathway. miR-26a-5p could protect cardiomyocytes against I/R injury by regulating the PTEN/PI3K/AKT pathway, which offers a potential approach for myocardial I/R injury treatment.