cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13699237.v1
title: Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription

description: Microglia proliferation is critical for proper development and function of the central nervous system (CNS), while dysregulation of proliferation contributes to pathology. We recently reported that male inducible nitric oxide synthase knockout (iNOS<sup>−/−</sup>) mice displayed significantly more proliferating microglia in their postnatal cortex than age-matched wildtype (WT) male mice. Moreover, nitric oxide (NO) signaling in mouse microglia greatly upregulates calcium entry through transient receptor potential vanilloid type 2 (TRPV2) channels. Considering that TRPV2 activity restricts astrocytic proliferation within glioma tissues, we investigated the roles of iNOS/NO signaling and TRPV2 expression in the regulation of microglial proliferation in vitro using assays of calcium imaging, immunocytochemistry, western blot, and polymerase chain reaction. Results showed that non-dividing microglia exhibited substantially higher expression of TRPV2 on the plasma membrane and significantly larger calcium influx through TRPV2 channels in comparison to dividing microglia. Additionally, non-dividing WT microglia exhibited significantly more NO production than dividing WT microglia. Furthermore, the NO-donor NOC18 increased the nuclear translocation of nuclear factor of activated T-cells cytoplasmic 2 (NFATC2) and the mRNA of the cyclin-dependent kinase inhibitor p21 and decreased the percentage of dividing WT and iNOS<sup>–/–</sup> microglia in culture. Importantly, the presence of the TRPV2 inhibitor tranilast abolished these effects of NOC18. Together, results from this study indicated that iNOS/NO signaling inhibits microglial proliferation through TRPV2-mediated calcium influx, nuclear translocation of the transcription factor NFATC2, and p21 expression. Proposed molecular mechanism by which NO-TRPV2 signaling regulates microglia proliferation <i>in vitro.</i> Proposed molecular mechanism by which NO-TRPV2 signaling regulates microglia proliferation <i>in vitro.</i>
DOI: 10.2908/rail_tf_ns10_at
title: Zugbewegungen auf dem Schienennetzwerk - Österreich (2010)
title: Trafic ferroviaire sur le réseau ferré - Autriche (2010)
title: Train traffic on the rail network - Austria (2010)
DOI: 10.2908/rail_tf_ns10_be
title: Zugbewegungen auf dem Schienennetzwerk - Belgien (2010)
title: Trafic ferroviaire sur le réseau ferré - Belgique (2010)
title: Train traffic on the rail network - Belgium (2010)
DOI: 10.2908/rail_tf_ns10_bg
title: Trafic ferroviaire sur le réseau ferré - Bulgarie (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Bulgarien (2010)
title: Train traffic on the rail network - Bulgaria (2010)
DOI: 10.2908/rail_tf_ns10_ch
title: Train traffic on the rail network - Switzerland (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Schweiz (2010)
title: Trafic ferroviaire sur le réseau ferré - Suisse (2010)
DOI: 10.2908/rail_tf_ns10_cz
title: Train traffic on the rail network - Czech Republic (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Tschechische Republik 2010)
title: Trafic ferroviaire sur le réseau ferré -République Tchèque (2010)
DOI: 10.2908/rail_tf_ns10_de
title: Trafic ferroviaire sur le réseau ferré - Allemagne (2010)
title: Train traffic on the rail network - Germany (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Deutschland (2010)
DOI: 10.2908/rail_tf_ns10_dk
title: Trafic ferroviaire sur le réseau ferré - Danemark (2010)
title: Train traffic on the rail network - Denmark (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Dänemark (2010)
DOI: 10.2908/rail_tf_ns10_ee
title: Zugbewegungen auf dem Schienennetzwerk - Estland (2010)
title: Train traffic on the rail network - Estonia (2010)
title: Trafic ferroviaire sur le réseau ferré - Estonie (2010)
DOI: 10.2908/rail_tf_ns10_el
title: Train traffic on the rail network - Greece (2010)
title: Trafic ferroviaire sur le réseau ferré - Grèce (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Griechenland (2010)
DOI: 10.2908/rail_tf_ns10_es
title: Trafic ferroviaire sur le réseau ferré - Espagne (2010)
title: Train traffic on the rail network - Spain (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Spanien (2010)
DOI: 10.2908/rail_tf_ns10_fi
title: Zugbewegungen auf dem Schienennetzwerk - Finnland (2010)
title: Trafic ferroviaire sur le réseau ferré - Finlande (2010)
title: Train traffic on the rail network - Finland (2010)
DOI: 10.2908/rail_tf_ns10_fr
title: Trafic ferroviaire sur le réseau ferré - France (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Frankreich (2010)
title: Train traffic on the rail network - France (2010)
DOI: 10.2908/rail_tf_ns10_hr
title: Zugbewegungen auf dem Schienennetzwerk - Kroatien (2010)
title: Trafic ferroviaire sur le réseau ferré - Croatie (2010)
title: Train traffic on the rail network - Croatia (2010)
DOI: 10.2908/rail_tf_ns10_hu
title: Zugbewegungen auf dem Schienennetzwerk - Ungarn (2010)
title: Trafic ferroviaire sur le réseau ferré - Hongrie (2010)
title: Train traffic on the rail network - Hungary (2010)
DOI: 10.2908/rail_tf_ns10_ie
title: Trafic ferroviaire sur le réseau ferré - Irlande (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Irland (2010)
title: Train traffic on the rail network - Ireland (2010)
DOI: 10.2908/rail_tf_ns10_it
title: Train traffic on the rail network - Italia (2010)
title: Trafic ferroviaire sur le réseau ferré - Italie (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Italien (2010)
DOI: 10.2908/rail_tf_ns10_li
title: Train traffic on the rail network - Liechtenstein (2010)
title: Trafic ferroviaire sur le réseau ferré - Liechtenstein (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Liechtenstein (2010)
DOI: 10.2908/rail_tf_ns10_lt
title: Train traffic on the rail network - Lithuania (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Litauen (2010)
title: Trafic ferroviaire sur le réseau ferré - Lituanie (2010)
DOI: 10.2908/rail_tf_ns10_lu
title: Trafic ferroviaire sur le réseau ferré - Luxembourg (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Luxemburg (2010)
title: Train traffic on the rail network - Luxembourg (2010)
DOI: 10.2908/rail_tf_ns10_lv
title: Zugbewegungen auf dem Schienennetzwerk - Lettland (2010)
title: Trafic ferroviaire sur le réseau ferré - Lettonie (2010)
title: Train traffic on the rail network - Latvia (2010)
DOI: 10.2908/rail_tf_ns10_mk
title: Zugbewegungen auf dem Schienennetzwerk - Die ehemalige jugoslawische Republik Mazedonien (2010)
title: Trafic ferroviaire sur le réseau ferré - Ancienne République Yougoslave de Macédoine (2010)
title: Train traffic on the rail network - the Former Yugoslav Republic of Macedonia (2010)
DOI: 10.2908/rail_tf_ns10_nl
title: Trafic ferroviaire sur le réseau ferré - Pays-Bas (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Niederlande (2010)
title: Train traffic on the rail network - Netherlands (2010)
DOI: 10.2908/rail_tf_ns10_no
title: Trafic ferroviaire sur le réseau ferré - Norvège (2010)
title: Train traffic on the rail network - Norway (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Norwegen (2010)
DOI: 10.2908/rail_tf_ns10_pl
title: Trafic ferroviaire sur le réseau ferré - Pologne (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Polen (2010)
title: Train traffic on the rail network - Poland (2010)
DOI: 10.2908/rail_tf_ns10_pt
title: Train traffic on the rail network - Portugal (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Portugal (2010)
title: Trafic ferroviaire sur le réseau ferré - Portugal (2010)
DOI: 10.2908/rail_tf_ns10_ro
title: Trafic ferroviaire sur le réseau ferré - Roumanie (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Rumänien (2010)
title: Train traffic on the rail network - Romania (2010)
DOI: 10.2908/rail_tf_ns10_se
title: Zugbewegungen auf dem Schienennetzwerk - Schweden (2010)
title: Train traffic on the rail network - Sweden (2010)
title: Trafic ferroviaire sur le réseau ferré -Suède (2010)
DOI: 10.2908/rail_tf_ns10_si
title: Trafic ferroviaire sur le réseau ferré - Slovénie (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Slowenien (2010)
title: Train traffic on the rail network - Slovenia (2010)
DOI: 10.2908/rail_tf_ns10_sk
title: Trafic ferroviaire sur le réseau ferré - Slovaquie (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Slowakei (2010)
title: Train traffic on the rail network - Slovakia (2010)
DOI: 10.2908/rail_tf_ns10_tr
title: Train traffic on the rail network - Türkiye (2010)
title: Trafic ferroviaire sur le réseau ferré - Turquie (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Türkei (2010)
DOI: 10.2908/rail_tf_ns10_uk
title: Train traffic on the rail network - United Kingdom (2010)
title: Zugbewegungen auf dem Schienennetzwerk - Vereinigtes Königreich (2010)
title: Trafic ferroviaire sur le réseau ferré - Royaume-Uni (2010)
DOI: 10.2908/rail_tf_ns15_at
title: Train traffic on the rail network - Austria (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Österreich (2015)
title: Trafic ferroviaire sur le réseau ferré - Autriche (2015)
DOI: 10.2908/rail_tf_ns15_be
title: Trafic ferroviaire sur le réseau ferré - Belgique (2015
title: Zugbewegungen auf dem Schienennetzwerk - Belgien (2015
title: Train traffic on the rail network - Belgium (2015)
DOI: 10.2908/rail_tf_ns15_bg
title: Train traffic on the rail network - Bulgaria (2015)
title: Trafic ferroviaire sur le réseau ferré - Bulgarie (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Bulgarien (2015)
DOI: 10.2908/rail_tf_ns15_ch
title: Trafic ferroviaire sur le réseau ferré - Suisse (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Schweiz (2015)
title: Train traffic on the rail network - Switzerland (2015)
DOI: 10.2908/rail_tf_ns15_cz
title: Train traffic on the rail network - Czech Republic (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Tschechische Republik (2015)
title: Trafic ferroviaire sur le réseau ferré -République Tchèque (2015)
DOI: 10.2908/rail_tf_ns15_de
title: Train traffic on the rail network - Germany (2015)
title: Trafic ferroviaire sur le réseau ferré - Allemagne (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Deutschland (2015)
DOI: 10.2908/rail_tf_ns15_dk
title: Train traffic on the rail network - Denmark (2015)
title: Trafic ferroviaire sur le réseau ferré - Danemark (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Dänemark (2015)
DOI: 10.2908/rail_tf_ns15_ee
title: Trafic ferroviaire sur le réseau ferré - Estonie (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Estland (2015)
title: Train traffic on the rail network - Estonia (2015)
DOI: 10.2908/rail_tf_ns15_es
title: Train traffic on the rail network - Spain (2015)
title: Trafic ferroviaire sur le réseau ferré - Espagne (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Spanien (2015)
DOI: 10.2908/rail_tf_ns15_fi
title: Zugbewegungen auf dem Schienennetzwerk - Finnland (2015)
title: Train traffic on the rail network - Finland (2015)
title: Trafic ferroviaire sur le réseau ferré - Finlande (2015)
DOI: 10.2908/rail_tf_ns15_fr
title: Train traffic on the rail network - France (2015)
title: Trafic ferroviaire sur le réseau ferré - France (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Frankreich (2015)
DOI: 10.2908/rail_tf_ns15_hr
title: Train traffic on the rail network - Croatia (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Kroatien (2015)
title: Trafic ferroviaire sur le réseau ferré - Croatie (2015)
DOI: 10.2908/rail_tf_ns15_hu
title: Zugbewegungen auf dem Schienennetzwerk - Ungarn (2015)
title: Trafic ferroviaire sur le réseau ferré - Hongrie (2015)
title: Train traffic on the rail network - Hungary (2015)
DOI: 10.2908/rail_tf_ns15_ie
title: Trafic ferroviaire sur le réseau ferré - Irlande (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Irland (2015)
title: Train traffic on the rail network - Ireland (2015)
DOI: 10.2908/rail_tf_ns15_it
title: Zugbewegungen auf dem Schienennetzwerk - Italien (2015)
title: Train traffic on the rail network - Italia (2015)
title: Trafic ferroviaire sur le réseau ferré - Italie (2015)
DOI: 10.2908/rail_tf_ns15_li
title: Train traffic on the rail network - Liechtenstein (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Liechtenstein (2015)
title: Trafic ferroviaire sur le réseau ferré - Liechtenstein (2015)
DOI: 10.2908/rail_tf_ns15_lt
title: Trafic ferroviaire sur le réseau ferré - Lituanie (2015)
title: Train traffic on the rail network - Lithuania (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Litauen (2015)
DOI: 10.2908/rail_tf_ns15_lu
title: Train traffic on the rail network - Luxembourg (2015)
title: Trafic ferroviaire sur le réseau ferré - Luxembourg (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Luxemburg (2015)
DOI: 10.2908/rail_tf_ns15_lv
title: Train traffic on the rail network - Latvia (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Lettland (2015)
title: Trafic ferroviaire sur le réseau ferré - Lettonie (2015)
DOI: 10.6084/m9.figshare.9119459
title: The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

description: The <i>BCR-ABL1</i> fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) targeting the ABL kinase (such as imatinib) has dramatically improved survival of CML and Ph+ ALL patients. However, primary and acquired resistance to TKIs remains a clinical challenge. Ph+ leukemia patients who achieve a complete cytogenetic (CCR) or deep molecular response (MR) (≥4.5log reduction in <i>BCR-ABL1</i> transcripts) represent long-term survivors. Thus, the fast and early eradication of leukemic cells predicts MR and is the prime clinical goal for these patients. We show here that the first-in-class inhibitor of the Nedd8-activating enzyme (NAE1) MLN4924 effectively induced caspase-dependent apoptosis in Ph+ leukemia cells, and sensitized leukemic cells for ABL tyrosine kinase inhibitors (TKI) and hydroxyurea (HU). We demonstrate that MLN4924 induced DNA damage in Ph+ leukemia cells by provoking the activation of an intra S-phase checkpoint, which was enhanced by imatinib co-treatment. The combination of MLN4924 and imatinib furthermore triggered a dramatic shift in the expression of MCL1 and NOXA. Our data offers a clear rationale to explore the clinical activity of MLN4924 (alone and in combination with ABL TKI) in Ph+ leukemia patients
DOI: 10.6084/m9.figshare.9119459.v2
title: The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

description: The <i>BCR-ABL1</i> fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) targeting the ABL kinase (such as imatinib) has dramatically improved survival of CML and Ph+ ALL patients. However, primary and acquired resistance to TKIs remains a clinical challenge. Ph+ leukemia patients who achieve a complete cytogenetic (CCR) or deep molecular response (MR) (≥4.5log reduction in <i>BCR-ABL1</i> transcripts) represent long-term survivors. Thus, the fast and early eradication of leukemic cells predicts MR and is the prime clinical goal for these patients. We show here that the first-in-class inhibitor of the Nedd8-activating enzyme (NAE1) MLN4924 effectively induced caspase-dependent apoptosis in Ph+ leukemia cells, and sensitized leukemic cells for ABL tyrosine kinase inhibitors (TKI) and hydroxyurea (HU). We demonstrate that MLN4924 induced DNA damage in Ph+ leukemia cells by provoking the activation of an intra S-phase checkpoint, which was enhanced by imatinib co-treatment. The combination of MLN4924 and imatinib furthermore triggered a dramatic shift in the expression of MCL1 and NOXA. Our data offers a clear rationale to explore the clinical activity of MLN4924 (alone and in combination with ABL TKI) in Ph+ leukemia patients
DOI: 10.2908/rail_tf_ns15_mk
title: Zugbewegungen auf dem Schienennetzwerk - Die ehemalige jugoslawische Republik Mazedonien (2015)
title: Trafic ferroviaire sur le réseau ferré - Ancienne République Yougoslave de Macédoine (2015)
title: Train traffic on the rail network - the Former Yugoslav Republic of Macedonia (2015)
DOI: 10.2908/rail_tf_ns15_nl
title: Zugbewegungen auf dem Schienennetzwerk - Niederlande (2015)
title: Train traffic on the rail network - Netherlands (2015)
title: Trafic ferroviaire sur le réseau ferré - Pays-Bas (2015)
DOI: 10.2908/rail_tf_ns15_no
title: Train traffic on the rail network - Norway (2015)
title: Trafic ferroviaire sur le réseau ferré - Norvège (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Norwegen (2015)
DOI: 10.2908/rail_tf_ns15_pl
title: Zugbewegungen auf dem Schienennetzwerk - Polen (2015)
title: Train traffic on the rail network - Poland (2015)
title: Trafic ferroviaire sur le réseau ferré - Pologne (2015)
DOI: 10.2908/rail_tf_ns15_pt
title: Zugbewegungen auf dem Schienennetzwerk - Portugal (2015)
title: Trafic ferroviaire sur le réseau ferré - Portugal (2015)
title: Train traffic on the rail network - Portugal (2015)
DOI: 10.2908/rail_tf_ns15_ro
title: Zugbewegungen auf dem Schienennetzwerk - Rumänien (2015)
title: Train traffic on the rail network - Romania (2015)
title: Trafic ferroviaire sur le réseau ferré - Roumanie (2015)
DOI: 10.6084/m9.figshare.12851579
title: RETRACTED ARTICLE: MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancer

description: We, the Editors and Publisher of the journal <i>Cell Cycle</i>, have retracted the following article: Mingbo Cai, Zhenhua Hu, Liping Han, and Ruixia Guo. MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancer. Cell Cycle. 2020;19(19):2509-2518. doi: 10.1080/15384101.2020.1809258. Since publication, concerns have been raised about the integrity of the data in the article. When approached for an explanation, the authors have been unable to provide their original data and any further supporting information. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The authors agree with the retraction. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
DOI: 10.6084/m9.figshare.12851579.v3
title: RETRACTED ARTICLE: MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancer

description: We, the Editors and Publisher of the journal <i>Cell Cycle</i>, have retracted the following article: Mingbo Cai, Zhenhua Hu, Liping Han, and Ruixia Guo. MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancer. Cell Cycle. 2020;19(19):2509-2518. doi: 10.1080/15384101.2020.1809258. Since publication, concerns have been raised about the integrity of the data in the article. When approached for an explanation, the authors have been unable to provide their original data and any further supporting information. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The authors agree with the retraction. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
DOI: 10.6084/m9.figshare.9119459.v1
title: The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

description: The <i>BCR-ABL1</i> fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) targeting the ABL kinase (such as imatinib) has dramatically improved survival of CML and Ph+ ALL patients. However, primary and acquired resistance to TKIs remains a clinical challenge. Ph+ leukemia patients who achieve a complete cytogenetic (CCR) or deep molecular response (MR) (≥4.5log reduction in <i>BCR-ABL1</i> transcripts) represent long-term survivors. Thus, the fast and early eradication of leukemic cells predicts MR and is the prime clinical goal for these patients. We show here that the first-in-class inhibitor of the Nedd8-activating enzyme (NAE1) MLN4924 effectively induced caspase-dependent apoptosis in Ph+ leukemia cells, and sensitized leukemic cells for ABL tyrosine kinase inhibitors (TKI) and hydroxyurea (HU). We demonstrate that MLN4924 induced DNA damage in Ph+ leukemia cells by provoking the activation of an intra S-phase checkpoint, which was enhanced by imatinib co-treatment. The combination of MLN4924 and imatinib furthermore triggered a dramatic shift in the expression of MCL1 and NOXA. Our data offers a clear rationale to explore the clinical activity of MLN4924 (alone and in combination with ABL TKI) in Ph+ leukemia patients
DOI: 10.2908/rail_tf_ns15_se
title: Train traffic on the rail network - Sweden (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Schweden (2015)
title: Trafic ferroviaire sur le réseau ferré - Suède (2015)
DOI: 10.2908/rail_tf_ns15_si
title: Train traffic on the rail network - Slovenia (2015)
title: Trafic ferroviaire sur le réseau ferré - Slovénie (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Slowenien (2015)
DOI: 10.6084/m9.figshare.12851579.v2
title: MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancer

description: Human males absent on the first (hMOF) is a histone acetyltransferase (HAT) and is involved in the pathogenesis of various cancers. This article aimed to reveal the potential mechanism of the miR-572/hMOF/Sirt6 axis in ovarian cancer (OC). In this study, we found that the mRNA and protein levels of hMOF and Sirt6 were abnormally down-regulated in OC tissues and cells. Further study indicated that the overexpression of hMOF increased the level of H4 histone acetylation in the Sirt6 promoter region and enhanced the ability of hMOF to bind to the Sirt6 promoter in OC cells, and repressed the proliferation of SKOV3 cells and promoted the apoptosis of SKOV3 cells via up-regulating Sirt6. Moreover, it was found that miR-572 negatively regulated hMOF luciferase activity. After the transfection of miR-572 inhibitor into SKOV3 cells, the cell proliferation was significantly repressed, while this repression was reversed after the transfection of shRNA-hMOF. Besides, the overexpression of hMOF could significantly inhibit the growth of tumors. Overall, our findings uncovered a novel regulatory pattern of hMOF in OC progression and provided new insights for relieving OC.
DOI: 10.2908/rail_tf_ns15_sk
title: Trafic ferroviaire sur le réseau ferré - Slovaquie (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Slowakei (2015)
title: Train traffic on the rail network - Slovakia (2015)
DOI: 10.2908/rail_tf_ns15_tr
title: Trafic ferroviaire sur le réseau ferré - Turquie (2015)
title: Train traffic on the rail network - Türkiye (2015)
title: Zugbewegungen auf dem Schienennetzwerk - Türkei (2015)