cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26362419
title: Fabrication and characterization of apremilast-loaded zinc oxide-mesoporous silica nanoparticles for psoriasis treatment

description: <b>Aim:</b> The study was aimed to formulate and evaluate apremilast-loaded zinc oxide-mesoporous silica nanoparticles for treatment of psoriasis. <b>Materials & methods:</b> Mesoporous silica nanoparticles were prepared by using sol-gel method and evaluated for particle size, <i>in vitro</i> drug release, <i>in vitro</i> cytotoxicity study and <i>in vivo</i> pharmacodynamic study. <b>Results:</b> The synthesized mesoporous silica nanoparticles showed particle size of 319.9 ± 3.9 nm, with 24 ± 0.217% of loading capacity. <i>In vitro</i> cytotoxicity study on A-431 cell line showed increased anti-psoriatic activity of apremilast-loaded zinc oxide-mesoporous silica nanoparticles. <i>In vivo</i> pharmacodynamic study and histological studies showed improved efficacy of drug in imiquimod-induced psoriasis mice model. <b>Conclusion:</b> The apremilast-loaded zinc oxide-mesoporous silica nanoparticles showed improved therapeutic efficacy, suggesting that they are promising approach for topical treatment of psoriasis. Mesoporous silica nanoparticles (MSNs) were successfully prepared by the sol gel method. The structural characterization of MSNs was confirmed by the BET analysis and TEM analysis confirmed the uniform spherical formation of the MSNs. Zinc oxide was used as anti-inflammatory agent, antibacterial agent and has high biocompatibility. It absorbs the UV rays which is used in the phototherapy for the reduction of inflammation in the psoriasis. The amino functionalization of MSNs was performed to enhance the physical and chemical properties of the MSNs, and it was found that drug loading of apremilast was enhanced, it prevented leakage of drug and prevented aggregation of the particles. The zeta analysis and ninhydrin test confirmed the amino functionalization on MSNs. The <i>in vitro</i> and <i>ex vivo</i> drug-release study showed that sustained drug release was obtained in ZnO-MSNs. The cell viability studies showed enhanced efficacy of apremilast when loaded in the ZnO-MSNs. MSNs improved efficacy of apremilast in <i>in vivo</i>, imiquimod-induced psoriasis model, as the particle size of around 300 nm retained on the skin and sustained the drug release to elicit the action of drug.
DOI: 10.6084/m9.figshare.26362419.v1
title: Fabrication and characterization of apremilast-loaded zinc oxide-mesoporous silica nanoparticles for psoriasis treatment

description: <b>Aim:</b> The study was aimed to formulate and evaluate apremilast-loaded zinc oxide-mesoporous silica nanoparticles for treatment of psoriasis. <b>Materials & methods:</b> Mesoporous silica nanoparticles were prepared by using sol-gel method and evaluated for particle size, <i>in vitro</i> drug release, <i>in vitro</i> cytotoxicity study and <i>in vivo</i> pharmacodynamic study. <b>Results:</b> The synthesized mesoporous silica nanoparticles showed particle size of 319.9 ± 3.9 nm, with 24 ± 0.217% of loading capacity. <i>In vitro</i> cytotoxicity study on A-431 cell line showed increased anti-psoriatic activity of apremilast-loaded zinc oxide-mesoporous silica nanoparticles. <i>In vivo</i> pharmacodynamic study and histological studies showed improved efficacy of drug in imiquimod-induced psoriasis mice model. <b>Conclusion:</b> The apremilast-loaded zinc oxide-mesoporous silica nanoparticles showed improved therapeutic efficacy, suggesting that they are promising approach for topical treatment of psoriasis. Mesoporous silica nanoparticles (MSNs) were successfully prepared by the sol gel method. The structural characterization of MSNs was confirmed by the BET analysis and TEM analysis confirmed the uniform spherical formation of the MSNs. Zinc oxide was used as anti-inflammatory agent, antibacterial agent and has high biocompatibility. It absorbs the UV rays which is used in the phototherapy for the reduction of inflammation in the psoriasis. The amino functionalization of MSNs was performed to enhance the physical and chemical properties of the MSNs, and it was found that drug loading of apremilast was enhanced, it prevented leakage of drug and prevented aggregation of the particles. The zeta analysis and ninhydrin test confirmed the amino functionalization on MSNs. The <i>in vitro</i> and <i>ex vivo</i> drug-release study showed that sustained drug release was obtained in ZnO-MSNs. The cell viability studies showed enhanced efficacy of apremilast when loaded in the ZnO-MSNs. MSNs improved efficacy of apremilast in <i>in vivo</i>, imiquimod-induced psoriasis model, as the particle size of around 300 nm retained on the skin and sustained the drug release to elicit the action of drug.
DOI: 10.17632/56773rn2yd.1
title: Replication data for "The hidden costs of imposing minimum contributions to a global public good" (2nd R&R)

description: The attached files are R script and Excel file containing data from a laboratory experiment (Data) and a small additional data collection (Data_response) requested by the editor (referee). Using both datasets, replication.R creates all tests, tables and figures of the paper. The only exception is Table A1 which was taken directly from raw data.
DOI: 10.5281/zenodo.12806148
title: Wound Healing Assay Dataset (WHAD) and Cell Adhesion and Motility Assay Dataset (CAMAD)

description: Please refer to the repository:https://github.com/leonardo-iheme/whad_camad_datasets/tree/master
DOI: 10.5281/zenodo.12806149
title: Wound Healing Assay Dataset (WHAD) and Cell Adhesion and Motility Assay Dataset (CAMAD)

description: Please refer to the repository:https://github.com/leonardo-iheme/whad_camad_datasets/tree/master
DOI: 10.5281/zenodo.13141575
title: Dataset of Fentanyl Research: Key to Fighting the Opioid Crisis

description: List of documents included in the Opioids study. The Pubmed database IDs (PMIDs) are shown.
DOI: 10.5281/zenodo.13141576
title: Dataset of Fentanyl Research: Key to Fighting the Opioid Crisis

description: List of documents included in the Opioids study. The Pubmed database IDs (PMIDs) are shown.
DOI: 10.17632/fh8h4859nh.1
title: Real and synthetic 3D models of F50 sand grains

description: The dataset comprises 1,551 real sand grains obtained from synchrotron microcomputed tomography (SMT) scans and 50,000 synthetically generated sand grain 3D models created using a latent space denoising diffusion algorithm. The 3D surface models are provided as Wavefront OBJ files (.obj), and the original and generated point clouds, representing the 3D coordinates of the sand grain surfaces, can be extracted from the vertices of these surface meshes. 

The latent space denoising diffusion algorithm generates realistic synthetic sand grain point clouds that emulate the morphological features of real grains. The data shows that synthetic grains exhibit similar shape, size, and surface characteristics to the real grains, making it useful for studying granular assemblies' behavior in engineering applications. This dataset enables detailed analysis and comparison of real and synthetic sand grains, aiming to facilitate the development and validation of new models for granular material analysis. 

This dataset is part of the paper titled "Synthesizing Realistic Sand Assemblies with Denoising Diffusion in Latent Space" (2024) by Nikolaos N. Vlassis, WaiChing Sun, Khalid A. Alshibli, and Richard A. Regueiro.
DOI: 10.17632/tjsgr3688w.1
title: Comprehension of Demonstrative Pronouns in 4- to 6-year-old Children with High-Functioning Autism

description: Our aim in this paper was to explore the developmental trajectory of comprehension of locative demonstrative pronouns “Zhege”( this) and “nage” (that) in Mandarin Chinese in children with High-Functioning Autism (HFA) and typically development (TD) children between ages of 4 and 6. Using semi-structured interactive tasks, we designed three cuing settings, i.e., clueless, eye-gaze and pointing, each including the two locative  conditions of on-the-same side and on-opposite-sides. It was found that (1)in clueless settings the  4- to 6-year-old HFA group  performed less well than the TD group ,  and with gaze assisting the HFA group remained less capable in using them than their TD peers; (2) in the case that the speaker is located on the same side with the participant, the HFA group had greater difficulty understanding the demonstratives in clueless and gaze settings as compared with the TD group;and (3) the HFA group of 4 years of age and the TD group of 4 years of age had the pronoun-type effect, but the two groups reached congruence in understanding “zhege” and “nage”  when aided with pointing and gaze. These findings indicate that  children with HFA are impaired in processing such information  as gaze and location, which involves joint attention and the Theory of Mind (ToM). Nevertheless,  children with HFA have relatively preserved ability in using highly conspicuous pointing for the non-verbal clue virtually compensates the impairment.
DOI: 10.17632/tjsgr3688w.2
title: Comprehension of Demonstrative Pronouns in 4- to 6-year-old Children with High-Functioning Autism

description: Our aim in this paper was to explore the developmental trajectory of comprehension of locative demonstrative pronouns “Zhege”( this) and “nage” (that) in Mandarin Chinese in children with High-Functioning Autism (HFA) and typically development (TD) children between ages of 4 and 6. Using semi-structured interactive tasks, we designed three cuing settings, i.e., clueless, eye-gaze and pointing, each including the two locative conditions of on-the-same side and on-opposite-sides. It was found that (1)in clueless settings the 4- to 6-year-old HFA group performed less well than the TD group , and with gaze assisting the HFA group remained less capable in using them than their TD peers; (2) in the case that the speaker is located on the same side with the participant, the HFA group had greater difficulty understanding the demonstratives in clueless and gaze settings as compared with the TD group;and (3) the HFA group of 4 years of age and the TD group of 4 years of age had the pronoun-type effect, but the two groups reached congruence in understanding “zhege” and “nage” when aided with pointing and gaze. These findings indicate that children with HFA are impaired in processing such information as gaze and location, which involves joint attention and the Theory of Mind (ToM). Nevertheless, children with HFA have relatively preserved ability in using highly conspicuous pointing for the non-verbal clue virtually compensates the impairment.
DOI: 10.5281/zenodo.11471503
title: MedMNIST-C: Comprehensive benchmark and improved classifier robustness by simulating realistic image corruptions

description: Abstract: The integration of neural-network-based systems into clinical practice is limited by challenges related to domain generalization and robustness. The computer vision community established benchmarks such as ImageNet-C as a fundamental prerequisite to measure progress towards those challenges. Similar datasets are largely absent in the medical imaging community which lacks a comprehensive benchmark that spans across imaging modalities and applications. To address this gap, we create and open-source MedMNIST-C, a benchmark dataset based on the MedMNIST+ collection, covering 12 datasets and 9 imaging modalities. We simulate task and modality-specific image corruptions of varying severity to comprehensively evaluate the robustness of established algorithms against real-world artifacts and distribution shifts. We further provide quantitative evidence that our simple-to-use artificial corruptions allow for highly performant, lightweight data augmentation to enhance model robustness. Unlike traditional, generic augmentation strategies, our approach leverages domain knowledge, exhibiting significantly higher robustness when compared to widely adopted methods. By introducing MedMNIST-C and open-sourcing the corresponding library allowing for targeted data augmentations, we contribute to the development of increasingly robust methods tailored to the challenges of medical imaging. The code is available at github.com/francescodisalvo05/medmnistc-api.



This work has been accepted at the Workshop on Advancing Data Solutions in Medical Imaging AI @ MICCAI 2024 [preprint].


Note: Due to space constraints, we have uploaded all datasets except TissueMNIST-C. However, it can be reproduced via our APIs. 

Usage: We recommend using the demo code and tutorials available on our GitHub repository.

Citation: If you find this work useful, please consider citing us:



@article{disalvo2024medmnist,
  title={MedMNIST-C: Comprehensive benchmark and improved classifier robustness by simulating realistic image corruptions},
  author={Di Salvo, Francesco and Doerrich, Sebastian and Ledig, Christian},
  journal={arXiv preprint arXiv:2406.17536},
  year={2024}
}


Disclaimer: This repository is inspired by MedMNIST APIs and the ImageNet-C repository. Thus, please also consider citing MedMNIST, the respective source datasets (described here), and ImageNet-C.
DOI: 10.5281/zenodo.11471504
title: MedMNIST-C: Comprehensive benchmark and improved classifier robustness by simulating realistic image corruptions

description: Abstract: The integration of neural-network-based systems into clinical practice is limited by challenges related to domain generalization and robustness. The computer vision community established benchmarks such as ImageNet-C as a fundamental prerequisite to measure progress towards those challenges. Similar datasets are largely absent in the medical imaging community which lacks a comprehensive benchmark that spans across imaging modalities and applications. To address this gap, we create and open-source MedMNIST-C, a benchmark dataset based on the MedMNIST+ collection, covering 12 datasets and 9 imaging modalities. We simulate task and modality-specific image corruptions of varying severity to comprehensively evaluate the robustness of established algorithms against real-world artifacts and distribution shifts. We further provide quantitative evidence that our simple-to-use artificial corruptions allow for highly performant, lightweight data augmentation to enhance model robustness. Unlike traditional, generic augmentation strategies, our approach leverages domain knowledge, exhibiting significantly higher robustness when compared to widely adopted methods. By introducing MedMNIST-C and open-sourcing the corresponding library allowing for targeted data augmentations, we contribute to the development of increasingly robust methods tailored to the challenges of medical imaging. The code is available at github.com/francescodisalvo05/medmnistc-api.



This work has been accepted at the Workshop on Advancing Data Solutions in Medical Imaging AI @ MICCAI 2024 [preprint].


Note: Due to space constraints, we have uploaded all datasets except TissueMNIST-C. However, it can be reproduced via our APIs. 

Usage: We recommend using the demo code and tutorials available on our GitHub repository.

Citation: If you find this work useful, please consider citing us:



@article{disalvo2024medmnist,
  title={MedMNIST-C: Comprehensive benchmark and improved classifier robustness by simulating realistic image corruptions},
  author={Di Salvo, Francesco and Doerrich, Sebastian and Ledig, Christian},
  journal={arXiv preprint arXiv:2406.17536},
  year={2024}
}


Disclaimer: This repository is inspired by MedMNIST APIs and the ImageNet-C repository. Thus, please also consider citing MedMNIST, the respective source datasets (described here), and ImageNet-C.
DOI: 10.17632/tjsgr3688w.3
title: Comprehension of Spatial Demonstratives in 4- to 6-year-old Chinese-speaking Children with High-Functioning Autism

description: Our aim in this paper was to explore the developmental trajectory of comprehension of locative demonstrative pronouns “Zhe”( this) and “na” (that) in Mandarin Chinese in children with High-Functioning Autism (HFA) and typically development (TD) children between ages of 4 and 6. Using semi-structured interactive tasks, we designed three cuing settings, i.e., clueless, eye-gaze and pointing, each including the two locative conditions of on-the-same side and on-opposite-sides. It was found that (1)in clueless settings the 4- to 6-year-old HFA group performed less well than the TD group , and with gaze assisting the HFA group remained less capable in using them than their TD peers; (2) in the case that the speaker is located on the same side with the participant, the HFA group had greater difficulty understanding the demonstratives in clueless and gaze settings as compared with the TD group;and (3) the HFA group of 4 years of age and the TD group of 4 years of age had the pronoun-type effect, but the two groups reached congruence in understanding “zhe” and “na” when aided with pointing and gaze. These findings indicate that children with HFA are impaired in processing such information as gaze and location, which involves joint attention and the Theory of Mind (ToM). Nevertheless, children with HFA have relatively preserved ability in using highly conspicuous pointing for the non-verbal clue virtually compensates the impairment.
DOI: 10.17632/fcd8x2n97p.1
title: Pent-roof Geometric Model

description: The .pdf file shows how to calculate geometric properties of a sphere interacting with a pent-roof combustion chamber walls
DOI: 10.17632/j8bvnvcgzg.1
title: Supplementary material of "Different Effects of Carbon Pricing and Border Adjustment in Germany and Spain" by N. Hinterlang (2024)

description: This directory contains supplementary material of the paper "Different Effects of Carbon Pricing and Border Adjustment in Germany and Spain" by Natascha Hinterlang (Economic Modelling, forthcoming).

Supplementary material encompasses:


i) Appendix providing more details on the calibration (Appendix A), additional simulation results and robustness checks (Appendix B).

ii) Replication files for simulations of the multi-sectoral E-DSGE model EMuSe, including directories for all scenarios of the paper.
DOI: 10.17632/fcd8x2n97p.2
title: Pent-roof Geometric Model

description: The .pdf file shows how to calculate geometric properties of a sphere interacting with a pent-roof combustion chamber walls
DOI: 10.17632/rg8ksbfr8x.1
title: Wind Forecasting Dataset for STGATN

description: Our experimental area is located in the central part of Xinjiang, in the northwest region of China, between 86°57'51-"88°46'21" east longitude, and between 42°38'22-"44°23'26" north latitude. The experimental area covers large-scale wind farm such as the Sino-clean energy toli wind farm, the Guoneng dabancheng wind farm, the Xinjiang longyuan dabancheng wind farm, and the Huadian toli wind farm. We regard March, April, and May as spring, June, July, and August as summer, September, October, and November as autumn, and December, the following January, and the following February as winter. We collect hourly wind speed and surface pressure data from ERA5 for the years 2022 and 2023, and establish four datasets for spring, summer, autumn, and winter, namely LHZ_Spring, LHZ_Summer, LHZ_Autumn, and LHZ_Winter, for hourly wind speed forecasting. We calculate the daily average of wind speed and surface pressure based on the hourly data of 2022 and 2023, and create the LHZ dataset for daily wind speed forecasting.
DOI: 10.15468/dl.arnhm2
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is one of (Cepaea hortensis (O.F.Müller, 1774), Cepaea nemoralis (Linnaeus, 1758))",
 "Continent is Europe",
 "StateProvince is one of (England, Wales, Scotland)",
 "DecimalLatitude is less than 50",
 "DecimalLatitude is greater than or equal to 51"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043155-240626123714530/datasets/export for details.
DOI: 10.17632/s2fr33wjbj.1
title: Sensorimotor Intervention for Controlling Primitive Reflexes in Older Adults

description: The reemergence of primitive reflexes (PRs) in older adults is linked to cognitive impairment, but there are currently no methods to prevent or slow this. This study investigated whether a 16-week sensorimotor exercise program could help older adults and its potential impact on mental health. Of 115 participants over 60, 95 completed the study (mean age = 76.37, SD = 7.04 years, 22% men). The experimental group (n = 38) saw a nearly threefold decline in PRs, while the control group (n = 57) experienced a threefold increase. Cognitive function improved in the experimental group but not in the control group. PR changes were positively related to negative mental health indices and negatively related to well-being. These findings suggest that sensorimotor exercises can affect reemerging PRs and are associated with mental health benefits, potentially opening new research avenues for preventing cognitive and psychological decline in older adults.
DOI: 10.15468/dl.cgyk5u
title: Occurrence Download

description: A dataset containing 2427553 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Meleagris gallopavo Linnaeus, 1758)"
 ]
}

 The dataset includes 2427553 records from 251 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043151-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/z2t-16l-7jj
title: Chondrodite

description: Digital Specimen for the physical specimen hosted at Tallinn University of Technology.
DOI: 10.15468/dl.4v9b74
title: Occurrence Download

description: A dataset containing 3390 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cirsium nipponicum (Maxim.) Makino",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3390 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0200336-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q6ekwh
title: Occurrence Download

description: A dataset containing 1187 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Helenium pinnatifidum (Nutt.) Rydb."
 ]
}

 The dataset includes 1187 records from 57 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0238387-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8u95vq
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Exochaenium clavatum (Paiva & I.Nogueira) Kissling"
 ]
}

 The dataset includes 9 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0122058-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mdkjeg
title: Occurrence Download

description: A dataset containing 89 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "CoordinateUncertaintyInMeters 0.0-9800.0",
 "DatasetKey is iNaturalist Research-grade Observations",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Dipodomys ordii Woodhouse, 1853"
 ]
}

 The dataset includes 89 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0176885-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.