cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30448313.v3
title: <b>Temporal divergence and genome expansion in soil microbes sustain positive plant</b><b>–</b><b>soil feedbacks under crop rotation</b>

description: Sustainable food production relies on cropping systems that harness, rather than exhaust, the soil microbiome. Plant–soil feedbacks (PSFs) are shaped by interactions between microbial legacies from past crops and the microbial communities of current season. Still, their temporal dynamics and functional bases remain unclear. Using a multi-phase experiment with continuous wheat monoculture and wheat–soybean rotation, we show that monoculture progressively amplifies negative PSFs, while rotation sustains positive feedbacks enhancing plant growth. These outcomes were linked to a temporal partitioning of microbial influence: contemporary bacterial communities and persistent fungal legacies jointly determined feedback effects. Metagenomic analyses revealed that rotation consistently enriched microbes with larger genomes and broader functional capacity for nutrient cycling and pathogen defense. Inoculation experiments confirmed that large-genome bacteria promoted wheat growth, as supported by transcriptomic analyses showing upregulation of genes involved in nutrient mobilization, pathogen defense, and stress adaptation. Together, our results demonstrate that crop rotation drives eco-evolutionary shifts in soil microbiomes, favoring metabolically versatile, large-genome taxa, and highlight microbial genome size as a predictive trait for designing resilient and productive cropping systems.
DOI: 10.6084/m9.figshare.30448313.v2
title: <b>Temporal divergence and genome expansion in soil microbes sustain positive plant</b><b>–</b><b>soil feedbacks under crop rotation</b>

description: Sustainable food production relies on cropping systems that harness, rather than exhaust, the soil microbiome. Plant–soil feedbacks (PSFs) are shaped by interactions between microbial legacies from past crops and the microbial communities of current season. Still, their temporal dynamics and functional bases remain unclear. Using a multi-phase experiment with continuous wheat monoculture and wheat–soybean rotation, we show that monoculture progressively amplifies negative PSFs, while rotation sustains positive feedbacks enhancing plant growth. These outcomes were linked to a temporal partitioning of microbial influence: contemporary bacterial communities and persistent fungal legacies jointly determined feedback effects. Metagenomic analyses revealed that rotation consistently enriched microbes with larger genomes and broader functional capacity for nutrient cycling and pathogen defense. Inoculation experiments confirmed that large-genome bacteria promoted wheat growth, as supported by transcriptomic analyses showing upregulation of genes involved in nutrient mobilization, pathogen defense, and stress adaptation. Together, our results demonstrate that crop rotation drives eco-evolutionary shifts in soil microbiomes, favoring metabolically versatile, large-genome taxa, and highlight microbial genome size as a predictive trait for designing resilient and productive cropping systems.
DOI: 10.21227/nyvb-2r66
title: "testimagedata"

description: "A dataset for the simulation of UAV scene matching algorithms, containing SAR, visible, and infrared images."
DOI: 10.15468/dl.vtm2n9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Uroteuthis robsoni",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017136-251120083545085/datasets/export for details.
DOI: 10.15468/dl.2jsuwq
title: Occurrence Download

description: A dataset containing 6234 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hieracium albiflorum",
 "HasCoordinate is true"
 ]
}

 The dataset includes 6234 records from 119 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017137-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wp9bkg
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phrynopus oblivius"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017138-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u7mews
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Uroteuthis vossi",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017139-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.et35x8
title: Occurrence Download

description: A dataset containing 2268 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hilaria jamesii",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2268 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017140-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7tknkq
title: Occurrence Download

description: A dataset containing 16 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllomedusa duellmani"
 ]
}

 The dataset includes 16 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017141-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7jbpkf
title: Occurrence Download

description: A dataset containing 59 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((178.29209 -38.95929,176.7998 -38.63078,175.97961 -40.35366,176.94789 -40.50973,177.13258 -40.29877,178.29209 -38.95929))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Lophomyrtus obcordata"
 ]
}

 The dataset includes 59 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017142-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9bhnca
title: Occurrence Download

description: A dataset containing 1329 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "Month is one of (January, February, March, April, May, June, July, August, September, October)",
 "TaxonKey is Danaus plexippus",
 "Year 2025-2025"
 ]
}

 The dataset includes 1329 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017144-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n25zd2
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllomedusa ecuatoriana"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017146-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b23s6h
title: Occurrence Download

description: A dataset containing 104 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllomedusa perinesos"
 ]
}

 The dataset includes 104 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017147-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.aa5bw7
title: Occurrence Download

description: A dataset containing 142 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plectrohyla acanthodes"
 ]
}

 The dataset includes 142 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017148-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rdseqn
title: Occurrence Download

description: A dataset containing 1968 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Danaus plexippus",
 "Year 2024-2024"
 ]
}

 The dataset includes 1968 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017149-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.21644977
title: Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

description: Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general and focused fragment libraries that were screened in a biochemical inhibition assay. Screening revealed a new fragment-hit inhibitor of DdlB with a Ki value of 20.7 ± 4.5 µM. Binding to the enzyme was confirmed by an orthogonal biophysical method, surface plasmon resonance, making the hit a promising starting point for fragment development.
DOI: 10.6084/m9.figshare.21644977.v1
title: Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

description: Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general and focused fragment libraries that were screened in a biochemical inhibition assay. Screening revealed a new fragment-hit inhibitor of DdlB with a Ki value of 20.7 ± 4.5 µM. Binding to the enzyme was confirmed by an orthogonal biophysical method, surface plasmon resonance, making the hit a promising starting point for fragment development.
DOI: 10.6084/m9.figshare.21865192
title: Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells

description: Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC). However, after a certain period of responsiveness, ADT resistance occurs virtually in all patients and the disease progresses to lethal metastatic castration-resistant prostate cancer (mCRPC). Aberrant expression and function of the epigenetic modifiers EZH2 and BET over activates c-myc, an oncogenic transcription factor critically contributing to mCRPC. In the present work, we tested, for the first time, the combination of an EZH2 inhibitor with a BET inhibitor in metastatic PC cells. The combination outperformed single drugs in inhibiting cell viability, cell proliferation and clonogenic ability, and concomitantly reduced both c-myc and NF-kB expression. Although these promising results will warrant further in vivo validation, they represent the first step to establishing the rationale that the proposed combination might be suitable for mCRPC treatment, by exploiting molecular targets different from androgen receptor.
DOI: 10.6084/m9.figshare.21865192.v1
title: Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells

description: Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC). However, after a certain period of responsiveness, ADT resistance occurs virtually in all patients and the disease progresses to lethal metastatic castration-resistant prostate cancer (mCRPC). Aberrant expression and function of the epigenetic modifiers EZH2 and BET over activates c-myc, an oncogenic transcription factor critically contributing to mCRPC. In the present work, we tested, for the first time, the combination of an EZH2 inhibitor with a BET inhibitor in metastatic PC cells. The combination outperformed single drugs in inhibiting cell viability, cell proliferation and clonogenic ability, and concomitantly reduced both c-myc and NF-kB expression. Although these promising results will warrant further in vivo validation, they represent the first step to establishing the rationale that the proposed combination might be suitable for mCRPC treatment, by exploiting molecular targets different from androgen receptor.
DOI: 10.6084/m9.figshare.21428022
title: Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddings

description: Ligand-based drug design methods are thought to require large experimental datasets to become useful for virtual screening. In this work, we propose a computational strategy to design novel inhibitors of coronavirus main protease, M<sup>pro</sup>. The pipeline integrates publicly available screening and binding affinity data in a two-stage machine-learning model using the recent MACAW embeddings. Once trained, the model can be deployed to rapidly screen large libraries of molecules <i>in silico</i>. Several hundred thousand compounds were virtually screened and 10 of them were selected for experimental testing. From these 10 compounds, 8 showed a clear inhibitory effect on recombinant M<sup>pro</sup>, with half-maximal inhibitory concentration values (IC<sub>50</sub>) in the range 0.18–18.82 μM. Cellular assays were also conducted to evaluate cytotoxic, haemolytic, and antiviral properties. A promising lead compound against coronavirus M<sup>pro</sup> was identified with dose-dependent inhibition of virus infectivity and minimal toxicity on human MRC-5 cells.
DOI: 10.6084/m9.figshare.21428022.v2
title: Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddings

description: Ligand-based drug design methods are thought to require large experimental datasets to become useful for virtual screening. In this work, we propose a computational strategy to design novel inhibitors of coronavirus main protease, M<sup>pro</sup>. The pipeline integrates publicly available screening and binding affinity data in a two-stage machine-learning model using the recent MACAW embeddings. Once trained, the model can be deployed to rapidly screen large libraries of molecules <i>in silico</i>. Several hundred thousand compounds were virtually screened and 10 of them were selected for experimental testing. From these 10 compounds, 8 showed a clear inhibitory effect on recombinant M<sup>pro</sup>, with half-maximal inhibitory concentration values (IC<sub>50</sub>) in the range 0.18–18.82 μM. Cellular assays were also conducted to evaluate cytotoxic, haemolytic, and antiviral properties. A promising lead compound against coronavirus M<sup>pro</sup> was identified with dose-dependent inhibition of virus infectivity and minimal toxicity on human MRC-5 cells.
DOI: 10.15468/dl.afup2c
title: Occurrence Download

description: A dataset containing 79 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plectrohyla avia"
 ]
}

 The dataset includes 79 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017150-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17766663
title: SARS-CoV-2 Infektionen in Deutschland

description: Im Datensatz "SARS-CoV-2 Infektionen in Deutschland" des Robert Koch-Instituts werden die Daten basierend auf Meldungen zu SARS-CoV-2 Infektionen nach dem Infektionsschutzgesetz (IfSG) bereitgestellt. Darin enthalten sind Informationen auf Landkreisebene zu bestätigten Infektionen, Todesfällen und Genesungen, differenziert nach Altersgruppen und Geschlecht. Diese Daten dienen als Grundlage für epidemiologische Bewertungen und gesundheitspolitische Maßnahmen.
DOI: 10.15468/dl.ranbkr
title: Occurrence Download

description: A dataset containing 268 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((178.19744 -38.90959,176.75497 -38.51679,175.57388 -40.19344,176.56979 -40.64941,176.9911 -40.08007,177.71416 -39.7954,178.19744 -38.90959))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Myrsine australis"
 ]
}

 The dataset includes 268 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017151-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.agtcw9
title: Occurrence Download

description: A dataset containing 2073859 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tracheophyta",
 "DecimalLatitude is greater than or equal to 49.085278",
 "DecimalLatitude is less than or equal to 54.085278",
 "DecimalLongitude is greater than or equal to -10.0",
 "DecimalLongitude is less than or equal to -5.0",
 "HasCoordinate is TRUE",
 "HasGeospatialIssue is FALSE"
 ]
}

 The dataset includes 2073859 records from 224 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017130-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.etry6j
title: Occurrence Download

description: A dataset containing 83 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plectrohyla calthula"
 ]
}

 The dataset includes 83 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017152-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2ssarz
title: Occurrence Download

description: A dataset containing 2463115 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sordariomycetes",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2463115 records from 1471 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017131-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cocp4t
title: Occurrence Download

description: A dataset containing 197 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Reconstruction of surface water temperature of sediment core GIK12310-4, Cape Barbas, North-West Africa (Appendix Tab. 3)"
 ]
}

 The dataset includes 197 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002084-160822134323880/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7zbz96
title: Occurrence Download

description: A dataset containing 147778 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Ambrosia artemisiifolia L.)"
 ]
}

 The dataset includes 147778 records from 1228 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0186041-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h1xyfn
title: Occurrence Download

description: A dataset containing 180 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Year 1960-1990",
 "Geometry POLYGON((-180 79,180 79,180 81,-180 81,-180 79))",
 "HasCoordinate is true",
 "TaxonKey is Mammalia"
 ]
}

 The dataset includes 180 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027504-190918142434337/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vvgjds
title: Occurrence Download

description: A dataset containing 665 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brazil",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Rhinella granulosa (Spix, 1824)"
 ]
}

 The dataset includes 665 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0171908-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.e1cwk5
title: Occurrence Download

description: A dataset containing 1013 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rosa rugosa Thunb.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "or" : [
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Living Specimen"
 ]
 }
 ]
}

 The dataset includes 1013 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002084-170714134226665/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7ytn2p
title: Occurrence Download

description: A dataset containing 882 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dianthus algetanus Graells ex F.N.Williams"
 ]
}

 The dataset includes 882 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0171918-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jtsfvy
title: Occurrence Download

description: A dataset containing 62 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Xenopus lenduensis Evans, Greenbaum, Kusamba, Carter, Tobias, Mendel & Kelley, 2011"
 ]
}

 The dataset includes 62 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011694-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ks6vkj
title: Occurrence Download

description: A dataset containing 42 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Etheostoma rafinesquei Burr & Page, 1982"
 ]
}

 The dataset includes 42 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002084-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.