cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8832329
title: Supplementary Material for: Transcapillary Refilling Rate and Its Determinants during Haemodialysis with Standard and High Ultrafiltration Rates

description: <b><i>Background:</i></b> Achieving euvolaemia using ultrafiltration (UF) during haemodialysis (HD) without inducing haemodynamic instability presents a major clinical challenge. Transcapillary refill is a key factor in sustaining the circulating blood volume (BV) during UF, which is in turn predicted by the rate of refilling. However, absolute plasma refilling rate (PRR), its determinants and variability with UF rate (UFR), have not been reported in the literature. <b><i>Method:</i></b> We studied paired HD sessions (<i>n</i> = 48) in 24 patients over 2 consecutive mid-week HD treatments. Plasma refilling was measured using real-time, minute-by-minute relative BV changes obtained from the integrated BV monitoring device during UF. A fixed bolus dilution approach at the start of HD was used to calculate absolute BV. The first control HD session was undertaken with a standard UFR required to achieve the prescribed target weight, while during the second study session, a fixed (high) UFR (1 L/h) was applied, either in the first (<i>n</i> = 12 patients) or in the final hour (n = 12 patients) of the HD session. Participants’ had their hydration status measured pre- and post-HD using multifrequency bioimpedance (BIS). Blood pressure was measured at 15-min intervals and blood samples were collected at 7 intervals during HD sessions. <b><i>Results:</i></b> The mean PRR during a standard 4-hr HD session was 4.3 ± 2.0 mL/kg/h and varied between 2 and 6 mL/kg/h. There was a mean time delay of 22 min (range 13.3–35.0 min) for onset of plasma refilling after the application of UF irrespective of standard or high UFRs. The maximum refilling occurred during the second hour of HD (mean max PRR 6.8 mL/kg/h). UFR (beta = 0.60, <i>p</i> &lt; 0.01) and BIS derived pre-HD overhydration index (beta = 0.44, <i>p</i> = 0.01) were consistent, independent predictors of the mean PRR (<i>R</i><sup>2</sup> = 0.49) in all HD sessions. At high UFRs, PRR exceeded 10 mL/kg/h. The total overall plasma refill contribution to UF volume was not significantly different between standard and high UF. During interventions no significant haemodynamic instability was observed in the study. <b><i>Conclusion:</i></b>We describe absolute transcapillary refilling rate and its profile during HD with UF. The findings provide the basis for the development of UF strategies to match varying PRRs during HD. An approach to fluid removal, which is tailored to patients’ refilling rates and capacity, provides an opportunity for more precision in the practice of UF.
DOI: 10.6084/m9.figshare.8832326.v1
title: Impact of social support on psychosocial symptoms and quality of life in cancer patients: results of a multilevel model approach from a longitudinal multicenter study

description: <b>Background:</b> This prospective multicenter study aimed to investigate the courses of positive support (PS) and detrimental interaction (DI), two different aspects of social support, and the relation between social support and psychosocial distress and/or health-related quality of life (HRQOL) in a large sample of patients with different cancers. <b>Methods:</b> For this observational study, we enrolled adult patients with cancer from 13 comprehensive cancer centers (CCCs) in Germany. We included a total of 1087 patients in our analysis. We assessed the outcomes via standardized self-report questionnaires at three measurement points: at admission for acute care (T1), 6 (T2) and 12 months (T3) thereafter. Our outcome variables included PS and DI, depression and anxiety symptoms, distress, mental quality of life (MQoL) and physical QoL (PQoL). Data were analyzed using three-level hierarchical linear modeling (HLM) and group-based trajectory modeling. <b>Results:</b> During the first year after the cancer diagnosis, both PS and DI decreased in our sample. Baseline depression symptom severity was a significant predictor of PS and DI. Further analyses revealed significant associations between PS, DI and the course of depression and anxiety symptoms, and MQoL. PS buffered the negative effects of DI with regards to these variables. Low DI was associated with better PQoL, whereas PS was not. In general, the impact of social support on psychosocial outcomes was weak to moderate. <b>Conclusions:</b> Our findings provide evidence for the influence of PS and DI on psychosocial symptoms and HRQOL, and emphasize the importance of psycho-oncological interventions that strengthen PS and prevent or reduce DI for patients with cancer and their relatives.
DOI: 10.6084/m9.figshare.8832251
title: Table S5 Subjective ratings of air freshness, acute health symptoms and alertness (Mean±SD) at different time during exposure under different experimental conditions..docx

description: the effects of different time on human thermal responses
DOI: 10.6084/m9.figshare.8832242
title: Table S4 Subjective ratings of thermal environment (Mean±SD) at different time during exposure under different experimental conditions..docx

description: The effects of different time on human thermal comfort.
DOI: 10.6084/m9.figshare.8832251.v1
title: Table S5 Subjective ratings of air freshness, acute health symptoms and alertness (Mean±SD) at different time during exposure under different experimental conditions..docx

description: the effects of different time on human thermal responses
DOI: 10.6084/m9.figshare.8832242.v1
title: Table S4 Subjective ratings of thermal environment (Mean±SD) at different time during exposure under different experimental conditions..docx

description: The effects of different time on human thermal comfort.
DOI: 10.6084/m9.figshare.8832173
title: Protective Effects of Trimetazidine in Retarding Selenite-Induced Lens Opacification

description: <b>Purpose</b>: Cataracts are the leading cause of vision loss worldwide, and the over-production of reactive oxygen species (ROS) is the foremost underlying cause of cataracts. Reducing ROS levels can efficiently prevent lens opacification, as evidenced by many studies. Here, we inhibited ROS overproduction with trimetazidine (TMZ), which is an antioxidant, to explore the therapeutic effects of TMZ and the mechanism of lens opacification. <b>Materials and methods</b>: Sodium selenite-induced cataract formation resulted in a significant loss of lens transparency. This effect could be efficiently rescued by TMZ, which was further found to be an inhibitor of ROS production, as determined by assaying oxidative stress-related parameters (SOD activity, MDA, ·OH and H<sub>2</sub>O<sub>2</sub> levels) during cataract formation. The experimental protocols involving animal research were approved by the Animal Care and Ethics Committee of Wenzhou Medical University and conducted according to the Association for Research in Vision and Ophthalmology under the guidelines of the Animal Welfare Act (SYXK 2015–0009). <b>Results</b>: Our study found that TMZ can retard the onset and progression of lens opacification <i>in vivo</i> in experiments using Sprague-Dawley (SD) suckling rats and can rescue the morphology of HLEB<sub>3</sub> cells <i>in vitro</i>. The flow cytometry and DNA fragmentation assays showed that TMZ could prevent sodium selenite-induced apoptosis. The western blot analysing showed that the levels of apoptosis-associated Bcl-2 and Nrf2 were dramatically decreased following the sodium selenite treatment. In addition, the bisulfate DNA sequencing revealed that the demethylation of CpGs in the promoter region of <i>Keap1</i> was stimulated, and that this demethylation could be inhibited by TMZ by rescuing the Nrf2 expression level. <b>Conclusions</b>: Our findings indicate that the antioxidant TMZ strongly reduces ROS production, which ultimately delays the progression of cataract formation, suggesting that treatment with TMZ represents a novel, promising antioxidant protection to retard cataract formation.
DOI: 10.6084/m9.figshare.8832173.v1
title: Protective Effects of Trimetazidine in Retarding Selenite-Induced Lens Opacification

description: <b>Purpose</b>: Cataracts are the leading cause of vision loss worldwide, and the over-production of reactive oxygen species (ROS) is the foremost underlying cause of cataracts. Reducing ROS levels can efficiently prevent lens opacification, as evidenced by many studies. Here, we inhibited ROS overproduction with trimetazidine (TMZ), which is an antioxidant, to explore the therapeutic effects of TMZ and the mechanism of lens opacification. <b>Materials and methods</b>: Sodium selenite-induced cataract formation resulted in a significant loss of lens transparency. This effect could be efficiently rescued by TMZ, which was further found to be an inhibitor of ROS production, as determined by assaying oxidative stress-related parameters (SOD activity, MDA, ·OH and H<sub>2</sub>O<sub>2</sub> levels) during cataract formation. The experimental protocols involving animal research were approved by the Animal Care and Ethics Committee of Wenzhou Medical University and conducted according to the Association for Research in Vision and Ophthalmology under the guidelines of the Animal Welfare Act (SYXK 2015–0009). <b>Results</b>: Our study found that TMZ can retard the onset and progression of lens opacification <i>in vivo</i> in experiments using Sprague-Dawley (SD) suckling rats and can rescue the morphology of HLEB<sub>3</sub> cells <i>in vitro</i>. The flow cytometry and DNA fragmentation assays showed that TMZ could prevent sodium selenite-induced apoptosis. The western blot analysing showed that the levels of apoptosis-associated Bcl-2 and Nrf2 were dramatically decreased following the sodium selenite treatment. In addition, the bisulfate DNA sequencing revealed that the demethylation of CpGs in the promoter region of <i>Keap1</i> was stimulated, and that this demethylation could be inhibited by TMZ by rescuing the Nrf2 expression level. <b>Conclusions</b>: Our findings indicate that the antioxidant TMZ strongly reduces ROS production, which ultimately delays the progression of cataract formation, suggesting that treatment with TMZ represents a novel, promising antioxidant protection to retard cataract formation.
DOI: 10.6084/m9.figshare.8831354
title: Table S1 Order of exposures by a 4x4 Latin-square design

description: The order of exposure followed a 4 × 4 Latin-square design that balanced out any effects of the sequence of exposure to the temperatures.
DOI: 10.6084/m9.figshare.8831339
title: Evaluation of potential health effects associated with occupational and environmental exposure to styrene – an update

description: The potential chronic health risks of occupational and environmental exposure to styrene were evaluated to update health hazard and exposure information developed since the Harvard Center for Risk Analysis risk assessment for styrene was performed in 2002. The updated hazard assessment of styrene’s health effects indicates human cancers and ototoxicity remain potential concerns. However, mechanistic research on mouse lung tumors demonstrates these tumors are mouse-specific and of low relevance to human cancer risk. The updated toxicity database supports toxicity reference levels of 20 ppm (equates to 400 mg urinary metabolites mandelic acid + phenylglyoxylic acid/g creatinine) for worker inhalation exposure and 3.7 ppm and 2.5 mg/kg bw/day, respectively, for general population inhalation and oral exposure. No cancer risk value estimates are proposed given the established lack of relevance of mouse lung tumors and inconsistent epidemiology evidence. The updated exposure assessment supports inhalation and ingestion routes as important. The updated risk assessment found estimated risks within acceptable ranges for all age groups of the general population and workers with occupational exposures in non-fiber-reinforced polymer composites industries and fiber-reinforced polymer composites (FRP) workers using closed-mold operations or open-mold operations with respiratory protection. Only FRP workers using open-mold operations not using respiratory protection have risk exceedances for styrene and should be considered for risk management measures. In addition, given the reported interaction of styrene exposure with noise, noise reduction to sustain levels below 85 dB(A) needs be in place.
DOI: 10.6084/m9.figshare.8830799
title: Population structure in porcine

description: This data contain 320 samples in porcine for the study of population structures.<br>
DOI: 10.6084/m9.figshare.8831339.v1
title: Evaluation of potential health effects associated with occupational and environmental exposure to styrene – an update

description: The potential chronic health risks of occupational and environmental exposure to styrene were evaluated to update health hazard and exposure information developed since the Harvard Center for Risk Analysis risk assessment for styrene was performed in 2002. The updated hazard assessment of styrene’s health effects indicates human cancers and ototoxicity remain potential concerns. However, mechanistic research on mouse lung tumors demonstrates these tumors are mouse-specific and of low relevance to human cancer risk. The updated toxicity database supports toxicity reference levels of 20 ppm (equates to 400 mg urinary metabolites mandelic acid + phenylglyoxylic acid/g creatinine) for worker inhalation exposure and 3.7 ppm and 2.5 mg/kg bw/day, respectively, for general population inhalation and oral exposure. No cancer risk value estimates are proposed given the established lack of relevance of mouse lung tumors and inconsistent epidemiology evidence. The updated exposure assessment supports inhalation and ingestion routes as important. The updated risk assessment found estimated risks within acceptable ranges for all age groups of the general population and workers with occupational exposures in non-fiber-reinforced polymer composites industries and fiber-reinforced polymer composites (FRP) workers using closed-mold operations or open-mold operations with respiratory protection. Only FRP workers using open-mold operations not using respiratory protection have risk exceedances for styrene and should be considered for risk management measures. In addition, given the reported interaction of styrene exposure with noise, noise reduction to sustain levels below 85 dB(A) needs be in place.
DOI: 10.6084/m9.figshare.8831354.v1
title: Order of exposures by a 4x4 Latin-square design

description: The order of exposure followed a 4 × 4 Latin-square design that balanced out any effects of the sequence of exposure to the temperatures.
DOI: 10.6084/m9.figshare.8830475
title: Data File 2.csv

description: The propagation loss of Europium Aluminium composite incorporated polymer optical waveguide amplifier for 10 cm length at 617 nm by using cut back method.
DOI: 10.6084/m9.figshare.8829437
title: Data File 1.csv

description: Optical gain of the Europium Aluminium composite incorporated polymer optical waveguide amplifier versus pump power with the variation of waveguide length ranging from 8 to 13 cm.
DOI: 10.6084/m9.figshare.8830475.v1
title: Data File 2.csv

description: The propagation loss of Europium Aluminium composite incorporated polymer optical waveguide amplifier for 10 cm length at 617 nm by using cut back method.
DOI: 10.25400/lincolnuninz.8829434
title: Meteorological observations at Lincoln: 2011

description: Lincoln meteorological observations have been taken at a range of sites over the years. A NIWA report (Mullan, A.B; Stuart, S.J; Hadfield, M.G; Smith, M.J (2010). Report on the Review of NIWA's 'Seven-Station' Temperature Series. NIWA Information Series No. 78. pp.129-154) records a number of these along with the work undertaken to reconcile the data between different sites. It is not yet clear which site(s) these measurements were taken at as we have not yet identified a correspondence with NIWA's records.<br><br>The datasets had been stored as .DAT files. The .DAT files have been uploaded as is, and also standardised and converted into .csv format.<br><br>Headers: The original .DAT files were stored without headers. Most of these could be recovered for the .csv by running the data through an old program that had been used in conjunction with the data, but one column remains "unknown".<br><br>Missing data: In the .DAT files, missing measurements are variously recorded, depending on context, as 0, -9, -99 or (in the case of Cloud cover) 9. In the .csv these values have been removed and left blank.<br><br>Units are most likely:<br><br>* solar radiation - probably MJ/m2 (megajoules per square metre)<br>* temperatures - Celsius (in early years possibly converted from an original measurement in Fahrenheit)<br>* rainfall - millimetres<br>* cloud - oktas (eighths of the sky taken up by cloud)<br>* wind run - kilometres<br>* vapour pressure - probably Pa (pascals)
DOI: 10.25400/lincolnuninz.8829428
title: Meteorological observations at Lincoln: 2009

description: Lincoln meteorological observations have been taken at a range of sites over the years. A NIWA report (Mullan, A.B; Stuart, S.J; Hadfield, M.G; Smith, M.J (2010). Report on the Review of NIWA's 'Seven-Station' Temperature Series. NIWA Information Series No. 78. pp.129-154) records a number of these along with the work undertaken to reconcile the data between different sites. It is not yet clear which site(s) these measurements were taken at as we have not yet identified a correspondence with NIWA's records.<br><br>The datasets had been stored as .DAT files. The .DAT files have been uploaded as is, and also standardised and converted into .csv format.<br><br>Headers: The original .DAT files were stored without headers. Most of these could be recovered for the .csv by running the data through an old program that had been used in conjunction with the data, but one column remains "unknown".<br><br>Missing data: In the .DAT files, missing measurements are variously recorded, depending on context, as 0, -9, -99 or (in the case of Cloud cover) 9. In the .csv these values have been removed and left blank.<br><br>Units are most likely:<br><br>* solar radiation - probably MJ/m2 (megajoules per square metre)<br>* temperatures - Celsius (in early years possibly converted from an original measurement in Fahrenheit)<br>* rainfall - millimetres<br>* cloud - oktas (eighths of the sky taken up by cloud)<br>* wind run - kilometres<br>* vapour pressure - probably Pa (pascals)
DOI: 10.25400/lincolnuninz.8829431
title: Meteorological observations at Lincoln: 2010

description: Lincoln meteorological observations have been taken at a range of sites over the years. A NIWA report (Mullan, A.B; Stuart, S.J; Hadfield, M.G; Smith, M.J (2010). Report on the Review of NIWA's 'Seven-Station' Temperature Series. NIWA Information Series No. 78. pp.129-154) records a number of these along with the work undertaken to reconcile the data between different sites. It is not yet clear which site(s) these measurements were taken at as we have not yet identified a correspondence with NIWA's records.<br><br>The datasets had been stored as .DAT files. The .DAT files have been uploaded as is, and also standardised and converted into .csv format.<br><br>Headers: The original .DAT files were stored without headers. Most of these could be recovered for the .csv by running the data through an old program that had been used in conjunction with the data, but one column remains "unknown".<br><br>Missing data: In the .DAT files, missing measurements are variously recorded, depending on context, as 0, -9, -99 or (in the case of Cloud cover) 9. In the .csv these values have been removed and left blank.<br><br>Units are most likely:<br><br>* solar radiation - probably MJ/m2 (megajoules per square metre)<br>* temperatures - Celsius (in early years possibly converted from an original measurement in Fahrenheit)<br>* rainfall - millimetres<br>* cloud - oktas (eighths of the sky taken up by cloud)<br>* wind run - kilometres<br>* vapour pressure - probably Pa (pascals)
DOI: 10.25400/lincolnuninz.8829434.v1
title: Meteorological observations at Lincoln: 2011

description: Lincoln meteorological observations have been taken at a range of sites over the years. A NIWA report (Mullan, A.B; Stuart, S.J; Hadfield, M.G; Smith, M.J (2010). Report on the Review of NIWA's 'Seven-Station' Temperature Series. NIWA Information Series No. 78. pp.129-154) records a number of these along with the work undertaken to reconcile the data between different sites. It is not yet clear which site(s) these measurements were taken at as we have not yet identified a correspondence with NIWA's records.<br><br>The datasets had been stored as .DAT files. The .DAT files have been uploaded as is, and also standardised and converted into .csv format.<br><br>Headers: The original .DAT files were stored without headers. Most of these could be recovered for the .csv by running the data through an old program that had been used in conjunction with the data, but one column remains "unknown".<br><br>Missing data: In the .DAT files, missing measurements are variously recorded, depending on context, as 0, -9, -99 or (in the case of Cloud cover) 9. In the .csv these values have been removed and left blank.<br><br>Units are most likely:<br><br>* solar radiation - probably MJ/m2 (megajoules per square metre)<br>* temperatures - Celsius (in early years possibly converted from an original measurement in Fahrenheit)<br>* rainfall - millimetres<br>* cloud - oktas (eighths of the sky taken up by cloud)<br>* wind run - kilometres<br>* vapour pressure - probably Pa (pascals)
DOI: 10.25400/lincolnuninz.8829422
title: Meteorological observations at Lincoln: 2008

description: Lincoln meteorological observations have been taken at a range of sites over the years. A NIWA report (Mullan, A.B; Stuart, S.J; Hadfield, M.G; Smith, M.J (2010). Report on the Review of NIWA's 'Seven-Station' Temperature Series. NIWA Information Series No. 78. pp.129-154) records a number of these along with the work undertaken to reconcile the data between different sites. It is not yet clear which site(s) these measurements were taken at as we have not yet identified a correspondence with NIWA's records.<br><br>The datasets had been stored as .DAT files. The .DAT files have been uploaded as is, and also standardised and converted into .csv format.<br><br>Headers: The original .DAT files were stored without headers. Most of these could be recovered for the .csv by running the data through an old program that had been used in conjunction with the data, but one column remains "unknown".<br><br>Missing data: In the .DAT files, missing measurements are variously recorded, depending on context, as 0, -9, -99 or (in the case of Cloud cover) 9. In the .csv these values have been removed and left blank.<br><br>Units are most likely:<br><br>* solar radiation - probably MJ/m2 (megajoules per square metre)<br>* temperatures - Celsius (in early years possibly converted from an original measurement in Fahrenheit)<br>* rainfall - millimetres<br>* cloud - oktas (eighths of the sky taken up by cloud)<br>* wind run - kilometres<br>* vapour pressure - probably Pa (pascals)