cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8128109
title: Correlation between cardiovascular parameters and glaucomatous changes in the optic nerve in patients with low-output heart failure

description: Abstract Objectives: To correlate ophthalmoscopic and cardiovascular parameters in patients diagnosed with low-output heart failure (HFrEF) and to evaluate the association between HFrEF and glaucoma-suggestive alterations in the optic nerve. Methods: Descriptive, observational and prospective study, composed of 30 patients diagnosed with HFrEF. The patients were submitted to ophthalmologic examination, which included biomicroscopy, visual acuity, gonioscopy, intraocular pressure (IOP) and central corneal thickness (CCT) measurement. Their cardiovascular parameters evaluation, such as mean arterial pressure (MAP), left ventricular ejection fraction (LVEF), comorbidities and diagnosis time of HFrEF was performed upon a review over their medical chart. The left eye was arbitrarily chosen for statistical analysis of the data. Statistical correlation was performed using the Spearman test, while the comparison was performed using the Mann-Whitney U-test. Results: A high prevalence of peripapillary atrophy (73.3%) was observed, as well as a positive, moderate and statistically significant correlation between LVEF and ocular perfusion pressure (OPP) (r = 0.517; p = 0.004). Despite the lack of significance of the Mann-Whitney U-Test comparisons, a higher prevalence of peripapillary atrophy was found in patients with lower MAP, lower LVEF and lower OPP. Conclusion: HFrEF may be a risk factor for the development of glaucomatous changes in the optic nerve disc. The resulting peripapillary atrophy and low OPP from the contractile deficit may be related to the vascular theory about normal-tension glaucoma development.
DOI: 10.6084/m9.figshare.8128109.v1
title: Correlation between cardiovascular parameters and glaucomatous changes in the optic nerve in patients with low-output heart failure

description: Abstract Objectives: To correlate ophthalmoscopic and cardiovascular parameters in patients diagnosed with low-output heart failure (HFrEF) and to evaluate the association between HFrEF and glaucoma-suggestive alterations in the optic nerve. Methods: Descriptive, observational and prospective study, composed of 30 patients diagnosed with HFrEF. The patients were submitted to ophthalmologic examination, which included biomicroscopy, visual acuity, gonioscopy, intraocular pressure (IOP) and central corneal thickness (CCT) measurement. Their cardiovascular parameters evaluation, such as mean arterial pressure (MAP), left ventricular ejection fraction (LVEF), comorbidities and diagnosis time of HFrEF was performed upon a review over their medical chart. The left eye was arbitrarily chosen for statistical analysis of the data. Statistical correlation was performed using the Spearman test, while the comparison was performed using the Mann-Whitney U-test. Results: A high prevalence of peripapillary atrophy (73.3%) was observed, as well as a positive, moderate and statistically significant correlation between LVEF and ocular perfusion pressure (OPP) (r = 0.517; p = 0.004). Despite the lack of significance of the Mann-Whitney U-Test comparisons, a higher prevalence of peripapillary atrophy was found in patients with lower MAP, lower LVEF and lower OPP. Conclusion: HFrEF may be a risk factor for the development of glaucomatous changes in the optic nerve disc. The resulting peripapillary atrophy and low OPP from the contractile deficit may be related to the vascular theory about normal-tension glaucoma development.
DOI: 10.6084/m9.figshare.8128103
title: Seed spacing variability reduces common bean yield

description: ABSTRACT An uneven seed spacing in the sowing row increases the plants intraspecific competition for environmental resources, potentially lowering grain yields. This study aimed to assess the yield and yield components of common bean plants, as a function of coefficients of variation (0 %, 20 %, 40 % and 60 %) of seeds in the sowing row. The main yield components, plant traits and grain yield were evaluated. The yield component that best explains the seed spacing variability on grain yield is the number of grains per plant (r = 0.94). Grain yield declines linearly as the seed spacing variability increases: 81.5 kg ha-1 (4.4 %) for every 10 % increase in the coefficient of variation. Thus, a less longitudinal seed spacing variability contributes to achieving higher grain yields.
DOI: 10.6084/m9.figshare.8128103.v1
title: Seed spacing variability reduces common bean yield

description: ABSTRACT An uneven seed spacing in the sowing row increases the plants intraspecific competition for environmental resources, potentially lowering grain yields. This study aimed to assess the yield and yield components of common bean plants, as a function of coefficients of variation (0 %, 20 %, 40 % and 60 %) of seeds in the sowing row. The main yield components, plant traits and grain yield were evaluated. The yield component that best explains the seed spacing variability on grain yield is the number of grains per plant (r = 0.94). Grain yield declines linearly as the seed spacing variability increases: 81.5 kg ha-1 (4.4 %) for every 10 % increase in the coefficient of variation. Thus, a less longitudinal seed spacing variability contributes to achieving higher grain yields.
DOI: 10.6084/m9.figshare.8128100
title: Désiré-Magloire Bourneville and his contributions to pediatric neurology

description: ABSTRACT Désiré-Magloire Bourneville ought to be thought of as the father of Pediatric Neurology for his significant contributions to the field. He worked as a physician, politician, writer, and editor. He was the first to describe the autosomal dominant genetic condition known as “tuberous sclerosis complex”, after conducting an autopsy on a young female patient, where the main finding in the central nervous system was multiple dense tubers. The patient had refractory epilepsy and intellectual disability. His work was based on the study of epilepsy and idiocy, and he was also an advocate of public health and social medicine education; creating day hospital programs for children with this type of neurologic disease.
DOI: 10.6084/m9.figshare.8128100.v1
title: Désiré-Magloire Bourneville and his contributions to pediatric neurology

description: ABSTRACT Désiré-Magloire Bourneville ought to be thought of as the father of Pediatric Neurology for his significant contributions to the field. He worked as a physician, politician, writer, and editor. He was the first to describe the autosomal dominant genetic condition known as “tuberous sclerosis complex”, after conducting an autopsy on a young female patient, where the main finding in the central nervous system was multiple dense tubers. The patient had refractory epilepsy and intellectual disability. His work was based on the study of epilepsy and idiocy, and he was also an advocate of public health and social medicine education; creating day hospital programs for children with this type of neurologic disease.
DOI: 10.6084/m9.figshare.8128097
title: Productivity and nutritive value of elephant grass pastures under organic and conventional production systems

description: Abstract: Elephant grass (EG) (Pennisetum purpureum Schum.) have great importance in tropical and subtropical climates, especially on dairy farms. Normally, EG is established alone under high fertilization levels. EG in organic production system can improve low production costs and environmental issues, are still little known. The aim of this research was to evaluate the performance of herbage yield, nutritive value, extraction/ export nutrient and forage yield and animal responses. Three production systems of EG were analyzed: (i) EG mixed spontaneous-growing species (SGE) in warm-season and ryegrass (R) in cool-season under organic production; (ii) EG mixed SGE + R under conventional system (positive control); and (iii) EG based under conventional production (control). Holstein cows were used in a rotational stocking. Forage samples were collected to evaluate the pasture and animal responses. Seven grazing cycles were performed during the experimental period (312 days). Herbage yield, forage intake, and stocking rate were 12548; 10270; 19168 kg ha-1 and 2.5; 2.6; 2.7% and 3.3; 2.1; 4.5 AU ha-1 day-1, respectively. Crude protein of EG was 17.9; 15.4; 16.4%, respectively. Mixed pastures, in conventional and organic production, had a better forage distribution throughout the seasons. Highest forage yield and extraction/ export nutrient was reported in pure EG within the conventional system.
DOI: 10.6084/m9.figshare.8128097.v1
title: Productivity and nutritive value of elephant grass pastures under organic and conventional production systems

description: Abstract: Elephant grass (EG) (Pennisetum purpureum Schum.) have great importance in tropical and subtropical climates, especially on dairy farms. Normally, EG is established alone under high fertilization levels. EG in organic production system can improve low production costs and environmental issues, are still little known. The aim of this research was to evaluate the performance of herbage yield, nutritive value, extraction/ export nutrient and forage yield and animal responses. Three production systems of EG were analyzed: (i) EG mixed spontaneous-growing species (SGE) in warm-season and ryegrass (R) in cool-season under organic production; (ii) EG mixed SGE + R under conventional system (positive control); and (iii) EG based under conventional production (control). Holstein cows were used in a rotational stocking. Forage samples were collected to evaluate the pasture and animal responses. Seven grazing cycles were performed during the experimental period (312 days). Herbage yield, forage intake, and stocking rate were 12548; 10270; 19168 kg ha-1 and 2.5; 2.6; 2.7% and 3.3; 2.1; 4.5 AU ha-1 day-1, respectively. Crude protein of EG was 17.9; 15.4; 16.4%, respectively. Mixed pastures, in conventional and organic production, had a better forage distribution throughout the seasons. Highest forage yield and extraction/ export nutrient was reported in pure EG within the conventional system.
DOI: 10.6084/m9.figshare.12871553
title: Supplementary Material for: AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3

description: <b><i>Background:</i></b> Chronic hyperglycemia, a pivotal feature of diabetes mellitus (DM), initiates the formation of advanced glycation end products (AGEs) and the dysregulation of epigenetic mechanisms, which may cause injury to renal podocytes, a central feature of diabetic kidney disease (DKD). Previous data of our group showed that AGEs significantly reduce the expression of NIPP1 (nuclear inhibitor of protein phosphatase 1) in podocytes in vitro as well as in human and murine DKD. NIPP1 was shown by others to interact with enhancer of zeste homolog 2 (EZH2), which catalyzes the repressive methylation of H3K27me3 on histone 3. Therefore, we hypothesized that AGEs can directly induce epigenetic changes in podocytes. <b><i>Methods:</i></b> We analyzed the relevance of AGEs on EZH2 expression and activity in a murine podocyte cell line. Cells were treated with 5 mg/mL glycated BSA for 24 h. To determine the meaning of EZH2 suppression, EZH2 activity was inhibited by incubating the cells with the pharmacological methyltransferase inhibitor 3-deazaneplanocin A; EZH2 expression was repressed with siRNA. mRNA expression was analyzed with real-time PCR, and protein expression with Western blot. EZH2 expression and level of H3K27 trimethylation in podocytes of diabetic <i>db</i>/<i>db</i> mice, a mouse model for type 2 DM, were analyzed using immunofluorescence. <b><i>Results:</i></b> Our data demonstrated that AGEs decrease EZH2 expression in podocytes and consequently reduce H3K27me3. This suppression of EZH2 mimicked the AGE effects and caused an upregulated expression of pathological factors that contribute to podocyte injury in DKD. In addition, analyses of <i>db</i>/<i>db</i> mice showed significantly reduced H3K27me3 and EZH2 expression in podocytes. Moreover, the suppression of NIPP1 and EZH2 showed similar effects regarding podocyte injury. <b><i>Conclusions:</i></b> Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD.
DOI: 10.6084/m9.figshare.8128094
title: Xylanase for meat-type quails from 15 to 35 days old

description: ABSTRACT The objective of this study was to evaluate the effect of the supplementation of two xylanases in the diet of meat-type quail on performance, morphology of the intestinal mucosa, metabolization of nutrients, and carcass yield. The experimental design was a completely randomized 2×3+1 factorial arrangement [two metabolisable energy reductions (70 and 140 kcal/kg), with or without the inclusion of two xylanases (A and B), plus a control treatment without xylanase), totalling seven treatments with five replicates and 42 quail each. Total excreta were collected at 28 days of age to determine the metabolisable coefficients of dry matter, crude protein (CP), neutral detergent fibre (NDF), and gross energy (GE). There was no interaction between the energetic reductions and inclusion of xylanases on performance variables of the birds. The 70 kcal/kg reduction led to better results for feed intake, weight gain, and feed conversion, while the 140 kcal/kg reduction led to worse results. In terms of jejunum morphometry, there was no interaction between energy reductions and inclusion of xylanases, although xylanases increased villi height and villus:crypt ratio. There was an interaction between energy reduction and inclusion of enzymes for the metabolisability coefficients of CP, NDF, and GE, leading to improvements in these coefficients. Xylanases A and B are effective in energy-reduced corn and soybean meal diets for 15 to 35-day-old quail.
DOI: 10.6084/m9.figshare.8128094.v1
title: Xylanase for meat-type quails from 15 to 35 days old

description: ABSTRACT The objective of this study was to evaluate the effect of the supplementation of two xylanases in the diet of meat-type quail on performance, morphology of the intestinal mucosa, metabolization of nutrients, and carcass yield. The experimental design was a completely randomized 2×3+1 factorial arrangement [two metabolisable energy reductions (70 and 140 kcal/kg), with or without the inclusion of two xylanases (A and B), plus a control treatment without xylanase), totalling seven treatments with five replicates and 42 quail each. Total excreta were collected at 28 days of age to determine the metabolisable coefficients of dry matter, crude protein (CP), neutral detergent fibre (NDF), and gross energy (GE). There was no interaction between the energetic reductions and inclusion of xylanases on performance variables of the birds. The 70 kcal/kg reduction led to better results for feed intake, weight gain, and feed conversion, while the 140 kcal/kg reduction led to worse results. In terms of jejunum morphometry, there was no interaction between energy reductions and inclusion of xylanases, although xylanases increased villi height and villus:crypt ratio. There was an interaction between energy reduction and inclusion of enzymes for the metabolisability coefficients of CP, NDF, and GE, leading to improvements in these coefficients. Xylanases A and B are effective in energy-reduced corn and soybean meal diets for 15 to 35-day-old quail.
DOI: 10.6084/m9.figshare.8128091
title: Effect of adding fungicide to mixtures of triazoles and strobilurins in the control of downy mildew and Asian soybean rust

description: ABSTRACT Fungicides used to control the Asian soybean rust are composed almost entirely of mixtures involving the systemic (triazoles) and meso-systemic (strobilurins) modes of action. However, to control the soybean downy mildew, only protective fungicides are available. The present study aimed to evaluate the effectiveness of fungicides with different modes of action in the control of downy mildew and Asian soybean rust. A field experiment was carried out in a randomized block design, with seven treatments [negative control; difenoconazole at V7 + (azoxystrobin + cyproconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; carbendazim and mancozeb at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + mancozeb in V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1 + mancozeb at R2 and R5.1; (tebuconazole + carbendazim) at V7 + azoxystrobin + tebuconazole at R2 and R5.1 + mancozeb at R2 and R5.1 + carbendazim at R5.1] and four replicates. The following variables were evaluated: disease severity based on diagrammatic scales, phytotoxicity, product effectiveness, defoliation, number of pods per plant, number of seeds per pod, 1,000-seed weight and yield. The treatments with mancozeb addition showed to be more efficient in reducing the severity of mildew and Asian soybean rust and defoliation, providing increased seed yields for the crop. For the soybean downy mildew, the treatments with addition of mancozeb to benzimidazole, strobilurins and triazoles were more efficient in reducing the severity and for the control.
DOI: 10.6084/m9.figshare.8128091.v1
title: Effect of adding fungicide to mixtures of triazoles and strobilurins in the control of downy mildew and Asian soybean rust

description: ABSTRACT Fungicides used to control the Asian soybean rust are composed almost entirely of mixtures involving the systemic (triazoles) and meso-systemic (strobilurins) modes of action. However, to control the soybean downy mildew, only protective fungicides are available. The present study aimed to evaluate the effectiveness of fungicides with different modes of action in the control of downy mildew and Asian soybean rust. A field experiment was carried out in a randomized block design, with seven treatments [negative control; difenoconazole at V7 + (azoxystrobin + cyproconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; carbendazim and mancozeb at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + mancozeb in V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1 + mancozeb at R2 and R5.1; (tebuconazole + carbendazim) at V7 + azoxystrobin + tebuconazole at R2 and R5.1 + mancozeb at R2 and R5.1 + carbendazim at R5.1] and four replicates. The following variables were evaluated: disease severity based on diagrammatic scales, phytotoxicity, product effectiveness, defoliation, number of pods per plant, number of seeds per pod, 1,000-seed weight and yield. The treatments with mancozeb addition showed to be more efficient in reducing the severity of mildew and Asian soybean rust and defoliation, providing increased seed yields for the crop. For the soybean downy mildew, the treatments with addition of mancozeb to benzimidazole, strobilurins and triazoles were more efficient in reducing the severity and for the control.
DOI: 10.6084/m9.figshare.8128088
title: Variations in Tissue-Specific Expression of Adipose Differentiation-Related Protein Gene in Two Native Yunnan Chicken Breeds

description: ABSTRACT Adipose differentiation-related protein (ADFP) is a fatty acid-binding protein that can promote the absorption of long-chain fatty acids. However, few results have been published regarding its role in Yunnan Native chicken breeds. The aim of this study was to determine ADFP gene tissue-specific expression in Piao chickens (PC) and Wuliangshan black-bone chickens (WBC) by RT-qPCR. The ontogenetic expression levels of the ADFP gene were significantly different during growth and development phases in the subcutaneous fat, liver, and pectoralis muscle of PC, and in the subcutaneous fat, liver, and pectoralis muscle of WBC (p&lt;0.05). Individual tissue-differential expression levelswere detectedon d 91 and 112 in PC, with highest levels determined in abdominal fat and subcutaneous fat, respectively. However, in WBC, the highest levels were determined on d 49, 91 and 112 d in the pectoralis muscle and liver. Correlation analysis revealed ADFP expression level in liver of WBC was significantly related with LW and HC (p&lt;0.05), while no significant correlations with carcass fatness (CF) were found in PC (p&gt;0.05). The results suggest ADFPdifferential expression in the liver and pectoral muscles of PC and WBC during the growth and development phases (p&lt;0.05). The observed expression patterns indicate that the ADFP gene plays an important role in lipid metabolism of PC and WBC, and that these patterns are expressed differently in the tissues of different chicken genotypes.
DOI: 10.6084/m9.figshare.8128088.v1
title: Variations in Tissue-Specific Expression of Adipose Differentiation-Related Protein Gene in Two Native Yunnan Chicken Breeds

description: ABSTRACT Adipose differentiation-related protein (ADFP) is a fatty acid-binding protein that can promote the absorption of long-chain fatty acids. However, few results have been published regarding its role in Yunnan Native chicken breeds. The aim of this study was to determine ADFP gene tissue-specific expression in Piao chickens (PC) and Wuliangshan black-bone chickens (WBC) by RT-qPCR. The ontogenetic expression levels of the ADFP gene were significantly different during growth and development phases in the subcutaneous fat, liver, and pectoralis muscle of PC, and in the subcutaneous fat, liver, and pectoralis muscle of WBC (p&lt;0.05). Individual tissue-differential expression levelswere detectedon d 91 and 112 in PC, with highest levels determined in abdominal fat and subcutaneous fat, respectively. However, in WBC, the highest levels were determined on d 49, 91 and 112 d in the pectoralis muscle and liver. Correlation analysis revealed ADFP expression level in liver of WBC was significantly related with LW and HC (p&lt;0.05), while no significant correlations with carcass fatness (CF) were found in PC (p&gt;0.05). The results suggest ADFPdifferential expression in the liver and pectoral muscles of PC and WBC during the growth and development phases (p&lt;0.05). The observed expression patterns indicate that the ADFP gene plays an important role in lipid metabolism of PC and WBC, and that these patterns are expressed differently in the tissues of different chicken genotypes.
DOI: 10.6084/m9.figshare.8128085
title: Host plants for mealybugs (Hemiptera: Pseudococcidae) in grapevine crops

description: ABSTRACT Mealybugs (Hemiptera: Pseudococcidae) are considered pest insects of economic importance in grapevine crops. They are highly polyphagous, feeding on host plants of about 250 families. This study aimed to identify host plants for mealybugs in grapevine crops, in the São Francisco Valley region, Brazil. The samples included weeds, ornamentals, windbreaks, fruit trees and native plants of the Caatinga biome. A total of 37 species of host plants for mealybugs were identified, distributed in 18 families. The Malvaceae family was the most frequent one, with eigth host species identified, followed by Fabaceae with four and Euphorbiaceae with three. Most of these host plants are being recorded here for the first time in association with mealybugs species. From the identified plant species, 24 are hosts for Maconelicoccus hirsutus, 16 for Phenacoccus solenopsis, one for Ferrisia virgata, one for Dysmicoccus brevipes and one for Planococcus citri. The obtained results are important to better understand the host plant diversity for mealybugs, in order to implement integrated pest management programs.