cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1568811.v2
title: Comparative efficacy of antibiotics for the treatment of acute bacterial skin and skin structure infections (ABSSSI): a systematic review and network meta-analysis

description: Objective:The objective was to conduct a systematic review and network meta-analysis (NMA) of existing treatments for ABSSSI focusing on the novel lipoglycopeptide oritavancin.Methods:EMBASE, MEDLINE, MEDLINE in Process, CENTRAL (Cochrane), and select conferences were searched for randomized controlled trials investigating antimicrobial agents for the treatment of ABSSSI. NMA was used to estimate the odds ratios of the Test-Of-Cure (TOC) and Early Clinical Response (ECR) outcomes for treatments relative to vancomycin in the ITT populations. Sub-group analyses in MRSA and MSSA populations were conducted for TOC; sensitivity analyses investigated the use of the clinically evaluable (CE) populations and the restriction to trials following the recent FDA guidelines for clinical trials.Results:The systematic review identified 52 trials. The most commonly investigated treatments were vancomycin and linezolid; most trials reported TOC, but not ECR. The posterior mean and 95% credible intervals for odds ratios of TOC for antimicrobial agents relative to vancomycin were: linezolid (1.55; 0.91–2.57), daptomycin (2.18; 0.90–5.42), and oritavancin 1200 mg (1.06; 0.80–1.43). The odds ratio of ECR for oritavancin 1200 mg was 1.02 (0.23–4.33). In the MRSA sub-group the odds ratios relative to vancomycin for TOC were: linezolid (1.55; 0.96–2.46), daptomycin (0.74; 0.13–3.66), and oritavancin 1200 mg (0.94; 0.44–2.02). In the MSSA sub-group they were linezolid (1.36; 0.15–13.34) and oritavancin 1200 mg (0.82; 0.08–7.83). These results were robust to the sensitivity analyses.Conclusions:This NMA provides a unified framework for the comparison of all available antimicrobial agents used in the treatment of ABSSSI and is the first to assess the ECR end-point. The results suggest equivalence of clinical efficacy between vancomycin, daptomycin, linezolid, and novel antimicrobial agents including oritavancin for the treatment of ABSSSI at TOC. The wide uncertainty margins indicate the heterogeneity of the available evidence and the need for further research.
DOI: 10.6084/m9.figshare.1568804
title: Insect diapause of very variable duration: the case of the palm nut bruchid <i>Pachymerus nucleorum</i> (Coleoptera: Chrysomelidae)

description: SummaryData are provided here showing that larval diapause in the tropical palm nut bruchid <i>Pachymerus nucleorum</i> (Fabricius) can extend up to a maximum of about five years, although for most individuals the duration ranges from 15 to 48 months. The data were obtained for insects originating from one source only that were held under one set of temperature and photoperiod conditions only so the wide variation in duration is attributed to maternal control. Staggering the adult emergence times of a parent’s progeny can be regarded as an evolutionary strategy that increases the chance that some at least encounter favourable biotic or abiotic conditions. It is believed that extended diapause may be quite widespread amongst insects, including those of temperate climates.
DOI: 10.6084/m9.figshare.1568804.v2
title: Insect diapause of very variable duration: the case of the palm nut bruchid <i>Pachymerus nucleorum</i> (Coleoptera: Chrysomelidae)

description: SummaryData are provided here showing that larval diapause in the tropical palm nut bruchid <i>Pachymerus nucleorum</i> (Fabricius) can extend up to a maximum of about five years, although for most individuals the duration ranges from 15 to 48 months. The data were obtained for insects originating from one source only that were held under one set of temperature and photoperiod conditions only so the wide variation in duration is attributed to maternal control. Staggering the adult emergence times of a parent’s progeny can be regarded as an evolutionary strategy that increases the chance that some at least encounter favourable biotic or abiotic conditions. It is believed that extended diapause may be quite widespread amongst insects, including those of temperate climates.
DOI: 10.6084/m9.figshare.1568798
title: Intraspecific comparison of two complete mitogenome sequences from the Korean water deer (Cervidae: <i>Hydropotes inermis argyropus</i>)

description: The complete mitogenome (KP203884) of <i>Hydropotes i. argyropus</i> (SC15) showed 99.7% nucleotide similarity with that of the Chinese <i>H. i. inermis</i>, whereas only 99.1% nucleotide similarity with the known mitogenome of the Korean <i>H. i. argyropus</i> (HC23). Comparison of amino acid sequence also showed that <i>H. i. argyropus</i> (SC15) was more similar to the Chinese <i>H. i. inermis</i> (99.8%) than <i>H. i. argyropus</i> (HC23) (99.5%). Thus, the comparative analyses of the mitogenomes reveal that the Korean water deer <i>H. i. argyropus</i> (SC15) is more closely related to the Chinese water deer <i>H. i. inermis</i> than to the other Korean <i>H. i. argyropus</i> (HC23).
DOI: 10.6084/m9.figshare.1568797
title: Beyond Normal: Preparing Undergraduates for the Work Force in a Statistical Consulting Capstone

description: In this article we chronicle the development of the undergraduate statistical consulting course at Miami University, from canned to client-based projects, and argue that if the course is well designed with suitable mentoring, students can perform remarkably sophisticated analyses of real-world data problems that require solutions beyond the methods encountered in previous classes. We review the historical context in which the consulting class evolved, describe the logistics of implementing it, and review assessment and student reaction to the course. We also illustrate the types of challenging projects the students are confronted with via two case studies and relate the skills learned and reinforced in this consulting class model to the skills demanded in the modern statistical work force. This course also provides an opportunity to strengthen and nurture key points from the new American Statistical Association guidelines for undergraduate programs: namely, communicating analyses of real and complex data that require the application of diverse statistical models and approaches. Supplementary materials for this article are available online. [Received December 2014. Revised July 2015.]
DOI: 10.6084/m9.figshare.1568804.v1
title: Insect diapause of very variable duration: the case of the palm nut bruchid <i>Pachymerus nucleorum</i> (Coleoptera: Chrysomelidae)

description: SummaryData are provided here showing that larval diapause in the tropical palm nut bruchid <i>Pachymerus nucleorum</i> (Fabricius) can extend up to a maximum of about five years, although for most individuals the duration ranges from 15 to 48 months. The data were obtained for insects originating from one source only that were held under one set of temperature and photoperiod conditions only so the wide variation in duration is attributed to maternal control. Staggering the adult emergence times of a parent’s progeny can be regarded as an evolutionary strategy that increases the chance that some at least encounter favourable biotic or abiotic conditions. It is believed that extended diapause may be quite widespread amongst insects, including those of temperate climates.
DOI: 10.6084/m9.figshare.1568798.v1
title: Intraspecific comparison of two complete mitogenome sequences from the Korean water deer (Cervidae: <i>Hydropotes inermis argyropus</i>)

description: The complete mitogenome (KP203884) of <i>Hydropotes i. argyropus</i> (SC15) showed 99.7% nucleotide similarity with that of the Chinese <i>H. i. inermis</i>, whereas only 99.1% nucleotide similarity with the known mitogenome of the Korean <i>H. i. argyropus</i> (HC23). Comparison of amino acid sequence also showed that <i>H. i. argyropus</i> (SC15) was more similar to the Chinese <i>H. i. inermis</i> (99.8%) than <i>H. i. argyropus</i> (HC23) (99.5%). Thus, the comparative analyses of the mitogenomes reveal that the Korean water deer <i>H. i. argyropus</i> (SC15) is more closely related to the Chinese water deer <i>H. i. inermis</i> than to the other Korean <i>H. i. argyropus</i> (HC23).
DOI: 10.6084/m9.figshare.1568798.v2
title: Intraspecific comparison of two complete mitogenome sequences from the Korean water deer (Cervidae: <i>Hydropotes inermis argyropus</i>)

description: The complete mitogenome (KP203884) of <i>Hydropotes i. argyropus</i> (SC15) showed 99.7% nucleotide similarity with that of the Chinese <i>H. i. inermis</i>, whereas only 99.1% nucleotide similarity with the known mitogenome of the Korean <i>H. i. argyropus</i> (HC23). Comparison of amino acid sequence also showed that <i>H. i. argyropus</i> (SC15) was more similar to the Chinese <i>H. i. inermis</i> (99.8%) than <i>H. i. argyropus</i> (HC23) (99.5%). Thus, the comparative analyses of the mitogenomes reveal that the Korean water deer <i>H. i. argyropus</i> (SC15) is more closely related to the Chinese water deer <i>H. i. inermis</i> than to the other Korean <i>H. i. argyropus</i> (HC23).
DOI: 10.6084/m9.figshare.1568796
title: Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment

description: Genomic studies suggest an association of circadian clock genes with bipolar disorder (BD) and lithium response in humans. Therefore, we tested mice mutant in various clock genes before and after lithium treatment in the forced swim test (FST), a rodent behavioral test used for evaluation of depressive-like states. We find that expression of circadian clock components, including <i>Per2, Cry1</i> and <i>Rev-erbα,</i> is affected by lithium treatment, and thus, these clock components may contribute to the beneficial effects of lithium therapy. In particular, we observed that <i>Cry1</i> is important at specific times of the day to transmit lithium-mediated effects. Interestingly, the pathways involving <i>Per2</i> and <i>Cry1,</i> which regulate the behavior in the FST and the response to lithium, are distinct as evidenced by the phosphorylation of GSK3β after lithium treatment and the modulation of dopamine levels in the striatum. Furthermore, we observed the co-existence of depressive and mania-like symptoms in <i>Cry1</i> knock-out mice, which resembles the so-called mixed state seen in BD patients. Taken together our results strengthen the concept that a defective circadian timing system may impact directly or indirectly on mood-related behaviors.
DOI: 10.6084/m9.figshare.1568797.v2
title: Beyond Normal: Preparing Undergraduates for the Work Force in a Statistical Consulting Capstone

description: In this article we chronicle the development of the undergraduate statistical consulting course at Miami University, from canned to client-based projects, and argue that if the course is well designed with suitable mentoring, students can perform remarkably sophisticated analyses of real-world data problems that require solutions beyond the methods encountered in previous classes. We review the historical context in which the consulting class evolved, describe the logistics of implementing it, and review assessment and student reaction to the course. We also illustrate the types of challenging projects the students are confronted with via two case studies and relate the skills learned and reinforced in this consulting class model to the skills demanded in the modern statistical work force. This course also provides an opportunity to strengthen and nurture key points from the new American Statistical Association guidelines for undergraduate programs: namely, communicating analyses of real and complex data that require the application of diverse statistical models and approaches. Supplementary materials for this article are available online. [Received December 2014. Revised July 2015.]
DOI: 10.6084/m9.figshare.1568793
title: Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in <i>Fusarium graminearum</i>

description: Disruption of two <i>Fusarium</i> genes that negatively regulate trichothecene biosynthesis was reported to cause a drastic increase in trichothecene production. However, careful inspection of these genes revealed that neither was significantly related to trichothecene production. Agmatine medium maintained the expression of trichothecene genes at significant levels, resulting in a 2–3-fold increase in the final yield, as compared to glutamine medium.
DOI: 10.6084/m9.figshare.1568796.v1
title: Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment

description: Genomic studies suggest an association of circadian clock genes with bipolar disorder (BD) and lithium response in humans. Therefore, we tested mice mutant in various clock genes before and after lithium treatment in the forced swim test (FST), a rodent behavioral test used for evaluation of depressive-like states. We find that expression of circadian clock components, including <i>Per2, Cry1</i> and <i>Rev-erbα,</i> is affected by lithium treatment, and thus, these clock components may contribute to the beneficial effects of lithium therapy. In particular, we observed that <i>Cry1</i> is important at specific times of the day to transmit lithium-mediated effects. Interestingly, the pathways involving <i>Per2</i> and <i>Cry1,</i> which regulate the behavior in the FST and the response to lithium, are distinct as evidenced by the phosphorylation of GSK3β after lithium treatment and the modulation of dopamine levels in the striatum. Furthermore, we observed the co-existence of depressive and mania-like symptoms in <i>Cry1</i> knock-out mice, which resembles the so-called mixed state seen in BD patients. Taken together our results strengthen the concept that a defective circadian timing system may impact directly or indirectly on mood-related behaviors.
DOI: 10.6084/m9.figshare.1568797.v1
title: Beyond Normal: Preparing Undergraduates for the Work Force in a Statistical Consulting Capstone

description: In this article we chronicle the evolution of the undergraduate statistical consulting course at Miami University, from canned to client-based projects, and argue that if the course is well designed with suitable mentoring, students can perform remarkably sophisticated analyses of real-world data problems that require solutions beyond the methods encountered in previous classes. We review the historical context in which the consulting class evolved, describe the logistics of implementing it, and review assessment and student reaction to the course. We also illustrate the types of challenging projects the students are confronted with via two case studies and relate the skills learned and reinforced in this consulting class model to the skills demanded in the modern statistical workforce. This course also provides an opportunity to strengthen and nurture key points from the new ASA guidelines for undergraduate programs: namely, communicating analyses of real and complex data that require the application of diverse statistical models and approaches.
DOI: 10.6084/m9.figshare.1568793.v1
title: Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in <i>Fusarium graminearum</i>

description: Disruption of two <i>Fusarium</i> genes that negatively regulate trichothecene biosynthesis was reported to cause a drastic increase in trichothecene production. However, careful inspection of these genes revealed that neither was significantly related to trichothecene production. Agmatine medium maintained the expression of trichothecene genes at significant levels, resulting in a 2–3-fold increase in the final yield, as compared to glutamine medium.
DOI: 10.6084/m9.figshare.1568796.v3
title: Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment

description: Genomic studies suggest an association of circadian clock genes with bipolar disorder (BD) and lithium response in humans. Therefore, we tested mice mutant in various clock genes before and after lithium treatment in the forced swim test (FST), a rodent behavioral test used for evaluation of depressive-like states. We find that expression of circadian clock components, including <i>Per2, Cry1</i> and <i>Rev-erbα,</i> is affected by lithium treatment, and thus, these clock components may contribute to the beneficial effects of lithium therapy. In particular, we observed that <i>Cry1</i> is important at specific times of the day to transmit lithium-mediated effects. Interestingly, the pathways involving <i>Per2</i> and <i>Cry1,</i> which regulate the behavior in the FST and the response to lithium, are distinct as evidenced by the phosphorylation of GSK3β after lithium treatment and the modulation of dopamine levels in the striatum. Furthermore, we observed the co-existence of depressive and mania-like symptoms in <i>Cry1</i> knock-out mice, which resembles the so-called mixed state seen in BD patients. Taken together our results strengthen the concept that a defective circadian timing system may impact directly or indirectly on mood-related behaviors.
DOI: 10.6084/m9.figshare.1568796.v2
title: Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment

description: Genomic studies suggest an association of circadian clock genes with bipolar disorder (BD) and lithium response in humans. Therefore, we tested mice mutant in various clock genes before and after lithium treatment in the forced swim test (FST), a rodent behavioral test used for evaluation of depressive-like states. We find that expression of circadian clock components, including <i>Per2, Cry1</i> and <i>Rev-erbα,</i> is affected by lithium treatment, and thus, these clock components may contribute to the beneficial effects of lithium therapy. In particular, we observed that <i>Cry1</i> is important at specific times of the day to transmit lithium-mediated effects. Interestingly, the pathways involving <i>Per2</i> and <i>Cry1,</i> which regulate the behavior in the FST and the response to lithium, are distinct as evidenced by the phosphorylation of GSK3β after lithium treatment and the modulation of dopamine levels in the striatum. Furthermore, we observed the co-existence of depressive and mania-like symptoms in <i>Cry1</i> knock-out mice, which resembles the so-called mixed state seen in BD patients. Taken together our results strengthen the concept that a defective circadian timing system may impact directly or indirectly on mood-related behaviors.
DOI: 10.6084/m9.figshare.1568787
title: Tracing engineered nanomaterials in biological tissues using coherent anti-Stokes Raman scattering (CARS) microscopy – A critical review

description: Nanomaterials (NMs) are used in an extremely diverse range of products and are increasingly entering the environment, driving a need to better understand their potential health effects in both humans and wildlife. A major challenge in nanoparticle (eco)toxicology is the ability to localise NMs post exposure, to enable more targeted biological effects analyses. A range of imaging techniques have been applied to do so, but they are limited, requiring either extensive processing of the material, staining or use of high intensity illumination that can lead to photo damage and/or have limited tissue penetration. Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free imaging technique, providing contrast based on the intrinsic molecular vibrations of a specimen, circumventing the need for chemical perturbation by exogenous labels. CARS uses near infra-red excitation wavelengths which allow microscopy at depths of several hundred microns in intact tissues and minimises photo-damage to live and delicate samples. Here we provide an overview of the CARS process and present a series of illustrative examples demonstrating its application for detecting NMs within biological tissues, ranging from isolated cells to whole organisms and including materials spanning metals to polymers. We highlight the advantages of this technique which include chemically selective live imaging and substantial depth penetration, but we also discuss its limitations when applied to nanotoxicology, which most notably include the lack of resolution for studies on single nanoparticles.
DOI: 10.6084/m9.figshare.1568787.v1
title: Tracing engineered nanomaterials in biological tissues using coherent anti-Stokes Raman scattering (CARS) microscopy – A critical review

description: Nanomaterials (NMs) are used in an extremely diverse range of products and are increasingly entering the environment, driving a need to better understand their potential health effects in both humans and wildlife. A major challenge in nanoparticle (eco)toxicology is the ability to localise NMs post exposure, to enable more targeted biological effects analyses. A range of imaging techniques have been applied to do so, but they are limited, requiring either extensive processing of the material, staining or use of high intensity illumination that can lead to photo damage and/or have limited tissue penetration. Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free imaging technique, providing contrast based on the intrinsic molecular vibrations of a specimen, circumventing the need for chemical perturbation by exogenous labels. CARS uses near infra-red excitation wavelengths which allow microscopy at depths of several hundred microns in intact tissues and minimises photo-damage to live and delicate samples. Here we provide an overview of the CARS process and present a series of illustrative examples demonstrating its application for detecting NMs within biological tissues, ranging from isolated cells to whole organisms and including materials spanning metals to polymers. We highlight the advantages of this technique which include chemically selective live imaging and substantial depth penetration, but we also discuss its limitations when applied to nanotoxicology, which most notably include the lack of resolution for studies on single nanoparticles.
DOI: 10.6084/m9.figshare.1568779
title: Spontaneous Dissociation of Fluocinolone Acetonide Sustained Release Implant (Retisert) with Dislocation into the Anterior Chamber

description: <i>Purpose</i>: To report two cases of spontaneous Retisert implant dissociation with dislocation of the medication reservoir into the anterior chamber.<i>Design and methods</i>: Case reports.<i>Results</i>: Two patients with chronic, noninfectious uveitis following Retisert implantation between 6 and 7 years prior presented with a complaint of a “white spot” in their right eyes. Both patients had previous pars plana vitrectomies. Anterior segment examination revealed a dislocated medication reservoir of the Retisert implant in the inferior portion of anterior chamber with associated reservoir-corneal endothelial touch and stromal edema. The reservoirs were subsequently retrieved via a pars plana approach and removed from the anterior chamber through a corneal incision.<i>Conclusions</i>: Spontaneous dissociation of the Retisert implant with dislocation of the medication reservoir into the anterior chamber can be a late complication of Retisert implantation. Eye care professionals and patients should be aware of this complication, particularly with long-term intraocular retention of this device.