cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4629610
title: Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis

description: The objective of the present systematic review and meta-analysis was to examine the literature and to identify the results of randomized controlled trials (RCTs) comparing the use of letrozole to clomiphene citrate (CC) for ovulation induction in patients with polycystic ovary syndrome (PCOS). An exhaustive electronic literature search was performed using the MEDLINE and EMBASE databases until October 2014. Seven prospective RCTs comparing the use of letrozole to CC in PCOS patients met the inclusion criteria. Overall, the seven included studies accounted for 1833 patients (906 in the letrozole group and 927 in the CC group) and for 4999 ovulation induction cycles (2455 in the letrozole group and 2544 in the CC group). Five of the included studies reported data on live birth rates. There was a statistically significant increase in the live birth and pregnancy rates in the letrozole group when compared to the CC group, with a relative risk (RR) = 1.55 (95% confidence interval (CI): 1.26–1.90; <i>I<sup>2</sup></i><sup> </sup>= 0%) and RR = 1.38 (95% CI: 1.05–1.83; <i>I<sup>2</sup></i><sup> </sup>= 61%), respectively. There were no differences in the multiple pregnancy, miscarriage and ovulation rates between the two groups. Our study found that letrozole is superior to CC when considering the live birth and pregnancy rates in patients with PCOS.
DOI: 10.6084/m9.figshare.4629616.v1
title: Prevention of ovarian hyperstimulation syndrome in a rat model: comparison of the efficacy of tocilizumab with that of ranibizumab, cabergoline, and a gonadotropin-releasing hormone antagonist

description: The aim of the study is to investigate the effects of the interleukin-6 (IL-6) blocker tocilizumab in a hyperstimulated rat model and compare it with ranibizumab, a gonadotropin-releasing hormone antagonist (GnRHA), and cabergoline. Forty-seven rats were randomly divided into the following seven groups: Group 1: OHS; Group 2: OHS+ GnRHA; Group 3: OHS + ranibizumab; Group 4: OHS + cabergoline; Group 5: OHS + low-dose tocilizumab (TL); Group 6: OHS + high-dose tocilizumab (TH); Group 7: sham. Ovarian weight was significantly lower only in the ranibizumab group than in the OHS group. Estrogen levels were significantly lower in the GnRHA group than in the OHS and the treatment groups. Progesterone levels were significantly lower in the ranibizumab, cabergoline, and TL groups than in the OHS group. Among the treatment groups, corpus luteum counts were lower than in the OHS group. Corpus luteum counts were lowest in the tocilizumab groups. IL-6 intensity was lower in all treatment groups than in the OHS group. In the ranibizumab group IL-6 intensity was the lowest. The TL group did not significantly differ from the GnRHA and cabergoline groups regarding IL-6 expression. Ovarian VEGF expression was significantly lower in all treatment groups. For the TL, ranibizumab, and cabergoline groups VEGF intensity was similar. Tocilizumab may be a new strategy for preventing ovarian hyperstimulation syndrome by inhibition of IL-6.
DOI: 10.6084/m9.figshare.4629610.v1
title: Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis

description: The objective of the present systematic review and meta-analysis was to examine the literature and to identify the results of randomized controlled trials (RCTs) comparing the use of letrozole to clomiphene citrate (CC) for ovulation induction in patients with polycystic ovary syndrome (PCOS). An exhaustive electronic literature search was performed using the MEDLINE and EMBASE databases until October 2014. Seven prospective RCTs comparing the use of letrozole to CC in PCOS patients met the inclusion criteria. Overall, the seven included studies accounted for 1833 patients (906 in the letrozole group and 927 in the CC group) and for 4999 ovulation induction cycles (2455 in the letrozole group and 2544 in the CC group). Five of the included studies reported data on live birth rates. There was a statistically significant increase in the live birth and pregnancy rates in the letrozole group when compared to the CC group, with a relative risk (RR) = 1.55 (95% confidence interval (CI): 1.26–1.90; <i>I<sup>2</sup></i><sup> </sup>= 0%) and RR = 1.38 (95% CI: 1.05–1.83; <i>I<sup>2</sup></i><sup> </sup>= 61%), respectively. There were no differences in the multiple pregnancy, miscarriage and ovulation rates between the two groups. Our study found that letrozole is superior to CC when considering the live birth and pregnancy rates in patients with PCOS.
DOI: 10.6084/m9.figshare.12909500
title: SLA_25May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 25 May 2018.
DOI: 10.6084/m9.figshare.12909500.v1
title: SLA_25May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 25 May 2018.
DOI: 10.6084/m9.figshare.12909509
title: SLA_30May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 30 May 2018.
DOI: 10.6084/m9.figshare.12909509.v1
title: SLA_30May2018

description: Gridded SLA data from cds.climate.copernicus.eu for 30 May 2018.
DOI: 10.6084/m9.figshare.4628323
title: Sample Dry Weights

description: Dry weights (tonnes/ha) of near surface vegetation (&lt; 25 cm in height) collected in four land cover types in Victoria, Australia. Ten circular 0.15m radius samples were randomly located within one 10 m radius plot for each landcover type. Samples were mulched and weighed. 100g subsamples were then extracted and dryed following NSW DPI (2004). The relative decrease in weight was then applied to the total sample given the final dry weight expressed. <br><b>NSW DPI</b> (2004) Silage note no. 7, measuring the dry matter content of forages. http://www.dpi.nsw.gov.au/__data/assets/pdf_file/0007/229291/silage-note-7-measuring-the-dry-matter-content-of-forages.pdf<br><br>
DOI: 10.6084/m9.figshare.4628323.v1
title: Sample Dry Weights

description: Dry weights (tonnes/ha) of near surface vegetation (&lt; 25 cm in height) collected in four land cover types in Victoria, Australia. Ten circular 0.15m radius samples were randomly located within one 10 m radius plot for each landcover type. Samples were mulched and weighed. 100g subsamples were then extracted and dryed following NSW DPI (2004). The relative decrease in weight was then applied to the total sample given the final dry weight expressed. <br><b>NSW DPI</b> (2004) Silage note no. 7, measuring the dry matter content of forages. http://www.dpi.nsw.gov.au/__data/assets/pdf_file/0007/229291/silage-note-7-measuring-the-dry-matter-content-of-forages.pdf<br><br>
DOI: 10.6084/m9.figshare.4628239
title: Image based point clouds

description: Image based point clouds produce using 12 downward looking images collected with an Panasonic FMC-FZ100 camera over a small (0.15 m radius) samples. Images were processed in Agisoft Photoscan using the high accuracy setting for image matching and high quality setting for dense cloud reconstruction.<br>Point clouds have been normalised using the lasheight tool of lastools.
DOI: 10.6084/m9.figshare.4628197
title: Dataset for: The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice

description: Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonists, including spatial working memory deficits in rodents. Here, we tested the ability of LY354740 to rescue spatial working memory performance in mice that lack the GluA1 subunit of the AMPA glutamate receptor, encoded by Gria1, a gene recently implicated in schizophrenia by genome-wide association studies. We found that LY354740 failed to rescue the spatial working memory deficit in Gria1-/- mice during rewarded alternation performance in the T-maze. In contrast, LY354740 did reduce the locomotor hyperactivity in these animals to a level that was similar to controls. A similar pattern was found with the dopamine receptor antagonist haloperidol, with no amelioration of the spatial working memory deficit in Gria1-/- mice, even though the same dose of haloperidol reduced their locomotor hyperactivity. These results with LY354740 contrast with the rescue of spatial working memory in models of glutamatergic hypofunction using non-competitive NMDAR antagonists. Future studies should determine whether group II mGluR agonists can rescue spatial working memory deficits with other NMDAR manipulations, including genetic models and other pharmacological manipulations of NMDAR function.
DOI: 10.6084/m9.figshare.4628197.v1
title: Dataset for: The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice

description: Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonists, including spatial working memory deficits in rodents. Here, we tested the ability of LY354740 to rescue spatial working memory performance in mice that lack the GluA1 subunit of the AMPA glutamate receptor, encoded by Gria1, a gene recently implicated in schizophrenia by genome-wide association studies. We found that LY354740 failed to rescue the spatial working memory deficit in Gria1-/- mice during rewarded alternation performance in the T-maze. In contrast, LY354740 did reduce the locomotor hyperactivity in these animals to a level that was similar to controls. A similar pattern was found with the dopamine receptor antagonist haloperidol, with no amelioration of the spatial working memory deficit in Gria1-/- mice, even though the same dose of haloperidol reduced their locomotor hyperactivity. These results with LY354740 contrast with the rescue of spatial working memory in models of glutamatergic hypofunction using non-competitive NMDAR antagonists. Future studies should determine whether group II mGluR agonists can rescue spatial working memory deficits with other NMDAR manipulations, including genetic models and other pharmacological manipulations of NMDAR function.
DOI: 10.6084/m9.figshare.4628194
title: Dataset for: An adaptive kriging method for solving nonlinear inverse statistical problems

description: In various environmental contexts, estimating the distribution of unobserved random vectors X_i from some noisy indirect observations H(X_i)+U_i is required. If the relation between X_i and the quantity H(X_i), measured with the error U_i, is implemented by a CPU-consuming computer model H, a major practical difficulty is to perform the statistical inference with a relatively small number of runs of H. Following Fu et al. (2014), a Bayesian statistical framework is considered to make use of possible prior knowledge on the parameters of the distribution of the X_i, which is assumed Gaussian. Moreover, a Markov Chain Monte Carlo (MCMC) algorithm is carried out to estimate their posterior distribution by replacing H by a kriging metamodel build from a limited number of simulated experiments. Two heuristics, involving two different criteria to be optimized, are proposed to sequentially design these computer experiments in the limits of a given computational budget. The first criterion is a Weighted Integrated Mean Square Error (WIMSE). The second one, called Expected Conditional Divergence (ECD), developed in the spirit of the Stepwise Uncertainty Reduction (SUR) (Vazquez and Bect 2009), is based on the discrepancy between two consecutive approximations of the target posterior distribution. Several numerical comparisons conducted over a toy example then a motivating hydraulic real case-study show that such adaptive designs can significantly outperform the classical choice of a maximin Latin Hypercube Design (LHD) of experiments. Dealing with a major concern in hydraulic engineering, a particular emphasis is placed upon the prior elicitation of the case-study, highlighting the overall feasibility of the methodology. Faster convergences and manageability considerations lead to recommend the use of the ECD criterion in practical applications.
DOI: 10.6084/m9.figshare.4628077
title: TLS Point Clouds

description: TLS point clouds captured using a FARO Focus 3D x130 Terrestrial Laser Scanner. Four scans merged using ground control spheres and clipped to the area of each sample as described in the manuscript. <br>Point clouds have been normalised using lasheight tool of lastools.<br><br>
DOI: 10.6084/m9.figshare.4628041
title: APC talk

description: APC talk 8/2/2017
DOI: 10.6084/m9.figshare.4628077.v1
title: TLS Point Clouds

description: TLS point clouds captured using a FARO Focus 3D x130 Terrestrial Laser Scanner. Four scans merged using ground control spheres and clipped to the area of each sample as described in the manuscript. <br>Point clouds have been normalised using lasheight tool of lastools.<br><br>
DOI: 10.6084/m9.figshare.4628017
title: Mangrove Cuckoo Radio-telemetry Study

description: Metadata for the file “Mangrove_Cuckoo_location_data_2012_2015.csv”. <br>This file includes data for 16 Mangrove Cuckoos (Coccyzus minor) that were captured and fitted with VHF radio-transmitters. Birds were captured on Sanibel Island, Florida, USA and on the adjacent mainland in Fort Myers, Florida, USA. Radio-tagged birds were tracked between 13 April 2012 - 18 January 2015. Most locations of marked birds were estimated by triangulating the signal of the radio transmitter, as obtained using a handheld radio antenna. Some locations were estimated by an observer in an airplane. Location of individuals detected during aerial searches was estimated from the plane's Global Positioning System (GPS) after the signal had been localized using directional antennae and close circling by the pilot. Based on field trials, the estimated mean telemetry error associated with ground-based telemetry was 35.1 m (SD = 28.6 m; range = 5.7 m - 105.3 m). The telemetry error associated with aerial searches is unknown.<br>The following columns are included in this file:<br>Frequency: The frequency of the attached radio transmitter and the unique identifier for each individual in the study. <br>Latitude: Latitude (decimal degree) of the individual at the specified date and time. <br>Longitude: Longitude (decimal degree) of the individual at the specified date and time. <br>Date: Date and time at which the radio signal was recorded and at which the individual bird’s position (latitude, longitude) was estimated. <br>Aerial_or_ground: Whether the location was estimated by an observer on the ground or an observer in an airplane<br>Location_type: A variable indicating whether the record pertains to the initial capture of the individual or to a subsequent relocation.<br>For more information on these data, contact the principal investigator:<br>John Lloydjlloyd@vtecostudies.org
DOI: 10.6084/m9.figshare.4628017.v1
title: Mangrove Cuckoo Radio-telemetry Study

description: Metadata for the file “Mangrove_Cuckoo_location_data_2012_2015.csv”. <br>This file includes data for 16 Mangrove Cuckoos (Coccyzus minor) that were captured and fitted with VHF radio-transmitters. Birds were captured on Sanibel Island, Florida, USA and on the adjacent mainland in Fort Myers, Florida, USA. Radio-tagged birds were tracked between 13 April 2012 - 18 January 2015. Most locations of marked birds were estimated by triangulating the signal of the radio transmitter, as obtained using a handheld radio antenna. Some locations were estimated by an observer in an airplane. Location of individuals detected during aerial searches was estimated from the plane's Global Positioning System (GPS) after the signal had been localized using directional antennae and close circling by the pilot. Based on field trials, the estimated mean telemetry error associated with ground-based telemetry was 35.1 m (SD = 28.6 m; range = 5.7 m - 105.3 m). The telemetry error associated with aerial searches is unknown.<br>The following columns are included in this file:<br>Frequency: The frequency of the attached radio transmitter and the unique identifier for each individual in the study. <br>Latitude: Latitude (decimal degree) of the individual at the specified date and time. <br>Longitude: Longitude (decimal degree) of the individual at the specified date and time. <br>Date: Date and time at which the radio signal was recorded and at which the individual bird’s position (latitude, longitude) was estimated. <br>Aerial_or_ground: Whether the location was estimated by an observer on the ground or an observer in an airplane<br>Location_type: A variable indicating whether the record pertains to the initial capture of the individual or to a subsequent relocation.<br>For more information on these data, contact the principal investigator:<br>John Lloydjlloyd@vtecostudies.org
DOI: 10.6084/m9.figshare.4627954
title: Open Science practices (set of images)

description: Set of research practices that could be part of an Open Science workflow, covering preparation, discovery, analysis, writing, publication, outreach and assessment. <br>These examples of open science practices were prepared for and collected at several workshops in 2016, with researchers, funders, publishers, citizen scientists, librarians, university administrators, tool and platform developers, government officials, and other stakeholders in scholarly communication. <br>Practices are also available as editable powerpoint slides, and as 'Wheel of Open Science' visualization (png and editable pptx), collected in the Figshare collection 'Open Science practices'. <br>A link to a Google sheet listing a larger collection of research practices (including all these open science practices) is provided below. <br><br>This work is part of the project 'Innovations in Scholarly Communication'
DOI: 10.6084/m9.figshare.4626388
title: Hormone and antioxidant responses of <i>Lilium</i> Oriental hybrids ‘Sorbonne’ bulblets to humic acid treatments <i>in vitro</i>

description: The lily cultivar introduction is a very long process and bulblet development a limiting element in the entire cycle. The aim of the present study was to acquire a highly synchronized model system to gain insight into the bulbing process. Subsequently, this system was implemented to quantify the efficacy of humic acid applications to evaluate the hypothesized positive effect on bulblet growth. Based on weight, bulblet production was promoted with low humic acid concentration treatment (0.2 mg/L, LHA), showing 0.47 g weight and 11.68 mm diameter, while inhibitory effects were observed with increased doses. LHA significantly decreased the gibberellic acid content, and a pronounced phytohormone balance (promotive/inhibitive) was observed, which might be beneficial for the translocation of assimilates from the shoot to sink organs (bulblets). Intriguingly, LHA increased superoxide dismutase, peroxidase, ascorbate peroxidase, catalase, and glutathione reductase activities compared with the control during the early development stages, implicating a possible role for elimination of reactive oxygen species, thereby favouring cell expansion. In conclusion, we initially reported the effects of HA on the development of bulbous plants, showing that a relatively low dose markedly increased the bulblets size via positive GA and antioxidant responses. However, the mechanism of action needs further evaluation.
DOI: 10.6084/m9.figshare.4626388.v1
title: Hormone and antioxidant responses of <i>Lilium</i> Oriental hybrids ‘Sorbonne’ bulblets to humic acid treatments <i>in vitro</i>

description: The lily cultivar introduction is a very long process and bulblet development a limiting element in the entire cycle. The aim of the present study was to acquire a highly synchronized model system to gain insight into the bulbing process. Subsequently, this system was implemented to quantify the efficacy of humic acid applications to evaluate the hypothesized positive effect on bulblet growth. Based on weight, bulblet production was promoted with low humic acid concentration treatment (0.2 mg/L, LHA), showing 0.47 g weight and 11.68 mm diameter, while inhibitory effects were observed with increased doses. LHA significantly decreased the gibberellic acid content, and a pronounced phytohormone balance (promotive/inhibitive) was observed, which might be beneficial for the translocation of assimilates from the shoot to sink organs (bulblets). Intriguingly, LHA increased superoxide dismutase, peroxidase, ascorbate peroxidase, catalase, and glutathione reductase activities compared with the control during the early development stages, implicating a possible role for elimination of reactive oxygen species, thereby favouring cell expansion. In conclusion, we initially reported the effects of HA on the development of bulbous plants, showing that a relatively low dose markedly increased the bulblets size via positive GA and antioxidant responses. However, the mechanism of action needs further evaluation.
DOI: 10.6084/m9.figshare.4626262
title: PowerPoint Slides for: Universal Sustained Viral Response to the Combination of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with/without Ribavirin in Patients on Hemodialysis Infected with Hepatitis C Virus Genotypes 1 and 4

description: <b><i>Background:</i></b> Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and is associated with poor prognosis. Treatment with interferon and ribavirin is poorly tolerated, and few data are available on the impact of new direct-acting antivirals (DAAs). This study was intended to analyze the efficacy and safety of treatment with a combination of ombitasvir/paritaprevir/ritonavir and dasabuvir with/without ribavirin in HCV-infected patients on HD from 3 hospitals. <b><i>Methods:</i></b> This is a multicentric study. We analyze the clinical course of all patients on HD with HCV infection who had been treated with the combination of ombitasvir/paritaprevir/ritonavir and dasabuvir in 3 hospitals in Madrid, Spain. All patients under treatment had undergone Transient elastography (FibroScan®) and HCV RNA (PCR) and HCV genotype were determined simultaneously. <b><i>Results:</i></b> Thirty-five patients aged 53.3 ± 8.9 years (68.6% males) and with genotypes 1 and 4 were treated with the DAA regimen, and 17 were also given ribavirin. The most common etiology was glomerular disease. Sustained viral response was achieved in 100% of patients. Adverse effects were negligible, and no patient had to discontinue treatment. The most significant side effect was anemia, which led to a significant increase in the dose of erythropoiesis-stimulating agents. Anemia was more marked in patients receiving ribavirin. No patients required transfusions. <b><i>Conclusion:</i></b> A combination of ombitasvir/paritaprevir/ritonavir and dasabuvir with/without ribavirin for the treatment of HCV in patients on HD is highly effective and causes minimal side effects. This regimen represents a major advance in disease management. A considerable improvement in prognosis seems likely.