cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.15178113
title: Supplementary Material for: Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma

description: <b><i>Introduction:</i></b> Immune checkpoint inhibitors (ICIs) are promising agents for the treatment of hepatocellular carcinoma (HCC). However, the establishment of noninvasive measure that could predict the response to ICIs is challenging. This study aimed to evaluate tumor responses to ICIs using the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), which was shown to reflect Wnt/β-catenin activating mutation. <b><i>Methods:</i></b> A total of 68 intrahepatic HCC nodules from 18 patients with unresectable HCC and Child-Pugh class A liver function who received anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy were enrolled in this study. All patients had viable intrahepatic lesions evaluable using the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI within the 6 months prior to the treatment. The relative enhancement ratio was calculated, and the time to nodular progression (TTnP) defined as 20% or more increase in each nodule was compared between higher or hypo-enhancement HCC nodules. Then, the progression-free survival (PFS) and objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) were compared between patients with and without HCC nodules with higher enhancement on hepatobiliary phase images. <b><i>Results:</i></b> The median PFS was 2.7 (95% confidence interval [CI]: 1.4–4.0) months in patients with HCC nodules with higher enhancement (<i>n</i> = 8) and 5.8 (95% CI: 0.0–18.9) months in patients with hypointense HCC nodules (<i>n</i> = 10) (<i>p</i> = 0.007). The median TTnP of HCC nodules with higher enhancement (<i>n</i> = 23) was 1.97 (95% CI: 1.86–2.07) months and that of hypointense HCC nodules (<i>n</i> = 45) was not reached (<i>p</i> = 0.003). The ORR was 12.5% (1/8) versus 30.0% (3/10); the disease control rate was 37.5% (3/8) versus 70.0% (7/10), respectively, in patients with or without higher enhancement intrahepatic HCC nodules. <b><i>Conclusion:</i></b> The TTnP on HCC nodules with higher enhancement and the median PFS in patients who carried higher enhancement intrahepatic HCC nodules were significantly shorter than those in hypointense HCC nodules with anti-PD-1/PD-L1 monotherapy. The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.
DOI: 10.6084/m9.figshare.15178113.v1
title: Supplementary Material for: Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma

description: <b><i>Introduction:</i></b> Immune checkpoint inhibitors (ICIs) are promising agents for the treatment of hepatocellular carcinoma (HCC). However, the establishment of noninvasive measure that could predict the response to ICIs is challenging. This study aimed to evaluate tumor responses to ICIs using the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), which was shown to reflect Wnt/β-catenin activating mutation. <b><i>Methods:</i></b> A total of 68 intrahepatic HCC nodules from 18 patients with unresectable HCC and Child-Pugh class A liver function who received anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy were enrolled in this study. All patients had viable intrahepatic lesions evaluable using the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI within the 6 months prior to the treatment. The relative enhancement ratio was calculated, and the time to nodular progression (TTnP) defined as 20% or more increase in each nodule was compared between higher or hypo-enhancement HCC nodules. Then, the progression-free survival (PFS) and objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) were compared between patients with and without HCC nodules with higher enhancement on hepatobiliary phase images. <b><i>Results:</i></b> The median PFS was 2.7 (95% confidence interval [CI]: 1.4–4.0) months in patients with HCC nodules with higher enhancement (<i>n</i> = 8) and 5.8 (95% CI: 0.0–18.9) months in patients with hypointense HCC nodules (<i>n</i> = 10) (<i>p</i> = 0.007). The median TTnP of HCC nodules with higher enhancement (<i>n</i> = 23) was 1.97 (95% CI: 1.86–2.07) months and that of hypointense HCC nodules (<i>n</i> = 45) was not reached (<i>p</i> = 0.003). The ORR was 12.5% (1/8) versus 30.0% (3/10); the disease control rate was 37.5% (3/8) versus 70.0% (7/10), respectively, in patients with or without higher enhancement intrahepatic HCC nodules. <b><i>Conclusion:</i></b> The TTnP on HCC nodules with higher enhancement and the median PFS in patients who carried higher enhancement intrahepatic HCC nodules were significantly shorter than those in hypointense HCC nodules with anti-PD-1/PD-L1 monotherapy. The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.
DOI: 10.23729/db4069a3-4a79-47e3-86fc-f4b2c32f5254
title: CircVol lab day 0 preview

description: Day 0 scans of the lab samples of CircVol. Collective CircVol entry: https://doi.org/10.23729/f9ce14e4-a657-471e-b755-37ff4b902b3f Preview of PAS-dataset https://doi.org/10.23729/2d8ab2de-005d-4cac-86c1-a0feba2f1c00
DOI: 10.6084/m9.figshare.15307182
title: Supplementary Material for: Development of Skin Rash Predicts Outcome of Anti-PD-1- and Anti-CTLA4-Based Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Cancer or Squamous Cell Carcinoma of the Head and Neck: A Single-Center Analysis

description: <b><i>Objective:</i></b> We report the spectrum of immune-related adverse effects (irAEs) and outcome observed in a single-center cohort of 100 patients treated with immune checkpoint inhibitors in a routine clinical setting. <b><i>Methods:</i></b> Tumor entities included non-small cell lung cancer (<i>n</i> = 28), head and neck squamous cell carcinoma (<i>n</i> = 28), urothelial carcinoma (<i>n</i> = 7), and others (<i>n</i> = 37). <b><i>Results:</i></b> irAEs were documented in 49% of cases analyzed, and the most frequent manifestation consisted of immune-mediated skin rash (28%), colitis (9%), pneumonitis (8%), hypothyroidism (7%), or hepatitis (6%). Skin rash correlated with improved progression-free survival. <b><i>Conclusion:</i></b> Development of immune-related skin rash was found to correlate with favorable outcome, suggesting its practical feasibility as a potential predictive surrogate marker.
DOI: 10.6084/m9.figshare.15322722
title: Supplementary Material for: Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study

description: <b><i>Background:</i></b> Long-term pulmonary sequelae following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia are not yet confirmed; however, preliminary observations suggest a possible relevant clinical, functional, and radiological impairment. <b><i>Objectives:</i></b> The aim of this study was to identify and characterize pulmonary sequelae caused by SARS-CoV-2 pneumonia at 6-month follow-up. <b><i>Methods:</i></b> In this multicentre, prospective, observational cohort study, patients hospitalized for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support (“oxygen only,” “continuous positive airway pressure,” and “invasive mechanical ventilation”) and followed up at 6 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6-min walking test, chest X-ray, physical examination, and modified Medical Research Council (mMRC) dyspnoea score were collected. <b><i>Results:</i></b> Between March and June 2020, 312 patients were enrolled (83, 27% women; median interquartile range age 61.1 [53.4, 69.3] years). The parameters that showed the highest rate of impairment were DLCO and chest X-ray, in 46% and 25% of patients, respectively. However, only a minority of patients reported dyspnoea (31%), defined as mMRC ≥1, or showed restrictive ventilatory defects (9%). In the logistic regression model, having asthma as a comorbidity was associated with DLCO impairment at follow-up, while prophylactic heparin administration during hospitalization appeared as a protective factor. The need for invasive ventilatory support during hospitalization was associated with chest imaging abnormalities. <b><i>Conclusions:</i></b> DLCO and radiological assessment appear to be the most sensitive tools to monitor patients with the coronavirus disease 2019 (COVID-19) during follow-up. Future studies with longer follow-up are warranted to better understand pulmonary sequelae.
DOI: 10.6084/m9.figshare.15322722.v1
title: Supplementary Material for: Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study

description: <b><i>Background:</i></b> Long-term pulmonary sequelae following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia are not yet confirmed; however, preliminary observations suggest a possible relevant clinical, functional, and radiological impairment. <b><i>Objectives:</i></b> The aim of this study was to identify and characterize pulmonary sequelae caused by SARS-CoV-2 pneumonia at 6-month follow-up. <b><i>Methods:</i></b> In this multicentre, prospective, observational cohort study, patients hospitalized for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support (“oxygen only,” “continuous positive airway pressure,” and “invasive mechanical ventilation”) and followed up at 6 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6-min walking test, chest X-ray, physical examination, and modified Medical Research Council (mMRC) dyspnoea score were collected. <b><i>Results:</i></b> Between March and June 2020, 312 patients were enrolled (83, 27% women; median interquartile range age 61.1 [53.4, 69.3] years). The parameters that showed the highest rate of impairment were DLCO and chest X-ray, in 46% and 25% of patients, respectively. However, only a minority of patients reported dyspnoea (31%), defined as mMRC ≥1, or showed restrictive ventilatory defects (9%). In the logistic regression model, having asthma as a comorbidity was associated with DLCO impairment at follow-up, while prophylactic heparin administration during hospitalization appeared as a protective factor. The need for invasive ventilatory support during hospitalization was associated with chest imaging abnormalities. <b><i>Conclusions:</i></b> DLCO and radiological assessment appear to be the most sensitive tools to monitor patients with the coronavirus disease 2019 (COVID-19) during follow-up. Future studies with longer follow-up are warranted to better understand pulmonary sequelae.
DOI: 10.5281/zenodo.5102830
title: Evaluation of the shucking of certain species of scallops contaminated with domoic acid with a view to the production of edible parts meeting the safety requirements foreseen in the Union legislation - Summary statistics on occurrence and consumption data and exposure assessment results

description: DomoicAcid_Raw_Occurrence_Data.CSV contains the raw occurrence dataset on Domoic Acid contaminant in scallops as extracted from EFSA DWH on the 9 June 2020, 16,369 samples presented in the opinion as described in its section 1.3.2. Occurrence data submitted to EFSA. The data is provided in .csv format. This dataset is compliant with EFSA SSD model and contains two additional columns documenting issues identified in the cleaning process (column: issue) and the action taken (column: outcome) to address the issue (e.g. delete record or update values in specific fields). The link to the catalogues of controlled terminologies can be found under "Related identifiers”. <strong>Annex_</strong> DomoicAcid Table of contents <br> Table A1 Description of FoodEx2 codes used to describe scallop species and their anatomical parts Table A2 Data cleaning steps applied to occurrence data on domoic acid in scallops Table A3 Percentage of Left-Censored data and descriptive statistics for Limits of detection (LODs) and Limits of quantification (LOQs) for domoic acid in scallops (mg/kg) Table A4 Descriptive statistics for domoic acid in scallops (mg/kg) as reported in the cleaned database (statistics weighted by number of units per sample) Table A5 Descriptive statistics of body tissue weights (g) of scallops as submitted by data providers
description: EU; XLSX; data.collection@efsa.europa.eu
DOI: 10.5281/zenodo.5102829
title: Evaluation of the shucking of certain species of scallops contaminated with domoic acid with a view to the production of edible parts meeting the safety requirements foreseen in the Union legislation - Summary statistics on occurrence and consumption data and exposure assessment results

description: DomoicAcid_Raw_Occurrence_Data.CSV contains the raw occurrence dataset on Domoic Acid contaminant in scallops as extracted from EFSA DWH on the 9 June 2020, 16,369 samples presented in the opinion as described in its section 1.3.2. Occurrence data submitted to EFSA. The data is provided in .csv format. This dataset is compliant with EFSA SSD model and contains two additional columns documenting issues identified in the cleaning process (column: issue) and the action taken (column: outcome) to address the issue (e.g. delete record or update values in specific fields). The link to the catalogues of controlled terminologies can be found under "Related identifiers”. <strong>Annex_</strong> DomoicAcid Table of contents <br> Table A1 Description of FoodEx2 codes used to describe scallop species and their anatomical parts Table A2 Data cleaning steps applied to occurrence data on domoic acid in scallops Table A3 Percentage of Left-Censored data and descriptive statistics for Limits of detection (LODs) and Limits of quantification (LOQs) for domoic acid in scallops (mg/kg) Table A4 Descriptive statistics for domoic acid in scallops (mg/kg) as reported in the cleaned database (statistics weighted by number of units per sample) Table A5 Descriptive statistics of body tissue weights (g) of scallops as submitted by data providers
description: EU; XLSX; data.collection@efsa.europa.eu
DOI: 10.6084/m9.figshare.15314919
title: Supplementary Material for: Symptomatic Nephroptosis of the Transplant: First Report of Diagnostic Workup and Successful Minimal-Invasive Treatment

description: The symptomatic nephroptosis of a kidney transplant is a rare and potentially fatal complication and requires fast diagnosis and treatment. In this report, we describe a case in which intermittent symptomatic hydronephrosis and an increase of the creatinine levels were the leading symptoms of nephroptosis. Moreover, we describe the diagnostic procedures and the successful minimal-invasive treatment. To our knowledge, this is the first report of a symptomatic transplant nephroptosis with consecutive intermittent hydronephrosis and without complications of perfusion solved with a minimal-invasive approach.
DOI: 10.34740/kaggle/dsv/2541196
title: 2021 World Population (updated daily)
DOI: 10.6084/m9.figshare.14946408
title: Free Roaming Cats in Public Spaces

description: Do sustainable development goals accept free-roaming cats in public places? We provide insights and solutions regarding how cities worldwide confront this question. We present a two-phase urban toolkit that can help create an urban ecology that balances the needs of communal cats with residents’ desires for quietude and safety. The data includes the bibliometric analysis about the free-roaming cats and out cities. <br>
DOI: 10.6084/m9.figshare.14946408.v1
title: Free Roaming Cats in Public Spaces

description: Do sustainable development goals accept free-roaming cats in public places? We provide insights and solutions regarding how cities worldwide confront this question. We present a two-phase urban toolkit that can help create an urban ecology that balances the needs of communal cats with residents’ desires for quietude and safety. The data includes the bibliometric analysis about the free-roaming cats and out cities. <br>
DOI: 10.34740/kaggle/dsv/2541216
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.17028/rd.lboro.15330600
title: Supplementary Information Files for A three-dimensional asymmetric power HEAVY model

description: Supplementary Information Files for A three-dimensional asymmetric power HEAVY model<br>This article proposes the three‐dimensional HEAVY system of daily, intra‐daily, and range‐based volatility equations. We augment the bivariate model with a third volatility metric, the Garman–Klass estimator, and enrich the trivariate system with power transformations and asymmetries. Most importantly, we derive the theoretical properties of the multivariate asymmetric power model and explore its finite‐sample performance through a simulation experiment on the size and power properties of the diagnostic tests employed. Our empirical application shows that all three power transformed conditional variances are found to be significantly affected by the powers of squared returns, realized measure, and range‐based volatility as well. We demonstrate that the augmentation of the HEAVY framework with the range‐based volatility estimator, leverage and power effects improves remarkably its forecasting accuracy. Finally, our results reveal interesting insights for investments, market risk measurement, and policymaking.<br>
DOI: 10.17028/rd.lboro.15330600.v1
title: Supplementary Information Files for A three-dimensional asymmetric power HEAVY model

description: Supplementary Information Files for A three-dimensional asymmetric power HEAVY model<br>This article proposes the three‐dimensional HEAVY system of daily, intra‐daily, and range‐based volatility equations. We augment the bivariate model with a third volatility metric, the Garman–Klass estimator, and enrich the trivariate system with power transformations and asymmetries. Most importantly, we derive the theoretical properties of the multivariate asymmetric power model and explore its finite‐sample performance through a simulation experiment on the size and power properties of the diagnostic tests employed. Our empirical application shows that all three power transformed conditional variances are found to be significantly affected by the powers of squared returns, realized measure, and range‐based volatility as well. We demonstrate that the augmentation of the HEAVY framework with the range‐based volatility estimator, leverage and power effects improves remarkably its forecasting accuracy. Finally, our results reveal interesting insights for investments, market risk measurement, and policymaking.<br>
DOI: 10.25573/serc.13073249
title: Dataset: 1999 CO2xCommunity Experiment Belowground Biomass

description: <b>Abstract</b><br>Belowground biomass for 20 of the 45 experiment plots in the "CO<sub>2</sub>xCommunity" experiment taken in August 1999. Samples were taken after 13 years of continuous treatment with elevated CO<sub>2</sub> at an approximate CO<sub>2</sub> concentration of 750 ppm. Two soil cores were taken from each ambient CO<sub>2</sub> and elevated CO<sub>2</sub> plot in two plant communities, the C3 and C4 communities. A third plant community in the experiment was not sampled. The soil cores were 5.1 cm in diameter and 100 cm in length, extracted with a piston corer in three sections at target intervals of 0-33 cm, 34-66 cm, and 67-100 cm. The soil cores were sub-sectioned horizontally by depth. All belowground biomass was recovered from the top 15 cm of the soil core. At depths greater than 15 cm some soil sub-sections were used to estimate belowground biomass while others were used to estimate bulk density. Belowground biomass was sorted into the morphological categories living roots, rhizomes, and culms, and litter (i.e., dead roots and detritus), and color categories that can be interpreted as coming from C4 grasses or C3 sedges to a rough approximation. The data were gap-filled for depth sub-sections with no belowground biomass data, and modeled to provide estimates of whole-profile root biomass to a depth of 1 m. Total below ground biomass was significantly (p=0.017) and positively affected by the experimental treatment. <i>Spartina patens</i> had significantly less below ground biomass than <i>Schoenoplectus americanus</i> (p&lt;0.0001). Detailed methods and other metadata are provided in the Read Me file. The dataset is composed of 11 files including the disaggregated data, the derived data for total biomass, and replicable workflow in R for calculating the derived data from disaggregated data.<br>
DOI: 10.48324/dandi.000054/0.210819.1229
title: Plitt & Giocomo (2021) Experience Dependent Contextual Codes in the Hippocampus. Nat Neuro

description: Data included in Plitt & Giocomo (2021) Nature Neuroscience
DOI: 10.48324/dandi.000054/0.210819.1230
title: Plitt & Giocomo (2021) Experience Dependent Contextual Codes in the Hippocampus. Nat Neuro

description: Data included in Plitt & Giocomo (2021) Nature Neuroscience
DOI: 10.5281/zenodo.5221412
title: Sentinel-2 parallax-based cloud detection - sample dataset

description: This repository archives the Sentinel-2 sample data used in: D. Frantz, E. Haß, A. Uhl, J. Stoffels, and J. Hill (2018): Improvement of the Fmask algorithm for Sentinel-2 images: Separating clouds from bright surfaces based on parallax effects. Remote Sensing of Environment 215, 471-481. https://doi.org/10.1016/j.rse.2018.04.046
DOI: 10.5281/zenodo.5221411
title: Sentinel-2 parallax-based cloud detection - sample dataset

description: This repository archives the Sentinel-2 sample data used in: D. Frantz, E. Haß, A. Uhl, J. Stoffels, and J. Hill (2018): Improvement of the Fmask algorithm for Sentinel-2 images: Separating clouds from bright surfaces based on parallax effects. Remote Sensing of Environment 215, 471-481. https://doi.org/10.1016/j.rse.2018.04.046
DOI: 10.6084/m9.figshare.11888157.v6
title: 9. DataInBrief: bacterial AntiSMASH annotated contigs, raw data

description: Bacterial antiSMASH results of contig annotations <br>
DOI: 10.25794/reference/um8maue7
title: Xcc-147

description: EGNPP 1.2 whit proteic bank from = swissprot_bacteria + 510 NCBI Xanthomonodales
DOI: 10.5517/ccdc.csd.cc21n34z
title: CCDC 1896150: Experimental Crystal Structure Determination

description: Related Article: Nadia Alessandra Carmo dos Santos, Elena Badetti, Federico Begato, Klaus Wurst, Giulia Licini, Cristiano Zonta|2021|Eur.J.Inorg.Chem.|2021|2942|doi:10.1002/ejic.202100392
DOI: 10.5517/ccdc.csd.cc21n350
title: CCDC 1896151: Experimental Crystal Structure Determination

description: Related Article: Nadia Alessandra Carmo dos Santos, Elena Badetti, Federico Begato, Klaus Wurst, Giulia Licini, Cristiano Zonta|2021|Eur.J.Inorg.Chem.|2021|2942|doi:10.1002/ejic.202100392
DOI: 10.5517/ccdc.csd.cc26mb17
title: CCDC 2044358: Experimental Crystal Structure Determination

description: Related Article: Abhishek Tripathi, Andrea Daolio, Andrea Pizzi, Zhifang Guo, David R. Turner, Alberto Baggioli, Antonino Famulari, Glen B. Deacon, Giuseppe Resnati, Harkesh B. Singh|2021|Chem.Asian J.|16|2351|doi:10.1002/asia.202100545
DOI: 10.5517/ccdc.csd.cc27040f
title: CCDC 2055703: Experimental Crystal Structure Determination

description: Related Article: Peng Lu, Xiang Ren, Haofeng Xu, Dongpo Lu, Yufeng Sun, Zhan Lu|2021|J.Am.Chem.Soc.|143|12433|doi:10.1021/jacs.1c04773