cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5896924.v1
title: Dataset from Relatedness decreases and reciprocity increases cooperation in Norway rats

description: Kin selection and reciprocity are two mechanisms underlying the evolution of cooperation, but the relative importance of kinship and reciprocity for decisions to cooperate are yet unclear for most cases of cooperation. Here we experimentally tested the relative importance of relatedness and received cooperation for decisions to help a conspecific in wild-type Norway rats (<i>Rattus norvegicus</i>). Test rats provided more food to non-kin than to siblings, and they generally donated more food to previously helpful social partners than to those that had refused help. The rats thus applied reciprocal cooperation rules irrespective of relatedness, highlighting the importance of reciprocal help for cooperative interactions among both related and unrelated conspecifics.
DOI: 10.6084/m9.figshare.5896846
title: Annual rainfall on Palmyra Atoll taken from the station rain gauge from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

description: Rainfall data
DOI: 10.6084/m9.figshare.5896846.v1
title: Annual rainfall on Palmyra Atoll taken from the station rain gauge from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

description: Rainfall data
DOI: 10.6084/m9.figshare.5896813
title: Mosquito trap results from Palmyra Atoll, by date, island and trap type from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

description: Mosquito trap data
DOI: 10.6084/m9.figshare.5896813.v1
title: Mosquito trap results from Palmyra Atoll, by date, island and trap type from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

description: Mosquito trap data
DOI: 10.6084/m9.figshare.5896789
title: Stan code and data for Apple proliferation joint model

description: The compressed file contains the rstan-code and the data set used to fit the joint model for the Apple proliferation disease. The data set includes data on environment, vector, pathogen and AP symptoms of apple trees.
DOI: 10.6084/m9.figshare.5896789.v1
title: Rstan-code and input data for the Apple proliferation joint mod

description: The compressed file contains the rstan-code and the data set used to fit the joint model for the Apple proliferation disease. The data set includes data on environment, vector, pathogen and AP symptoms of apple trees.
DOI: 10.6084/m9.figshare.5896771
title: One-Step Synthesis of 3,4-Diphenyl-2-pyrrolinones by Solvent-Free and Bi2O3-Catalyzed Approaches and Cytotoxicity Screening Against Glioma Cells.pdf

description: Multifunctionalized 2-pyrrolinones were synthesized from the formal aza-[3 + 2] cycloaddition reactionof acyclic enaminones and diphenylcyclopropenone. For primary enaminones, solventless reaction undermicrowave heating was developed. On the other hand, catalysis by Bi2O3under conventional heating wasthe more suitable strategy when secondary enaminones were employed. These conditions allowed thesynthesis of a set of 2-pyrrolinones with two vicinal phenyl substituents, which were evaluated forcytotoxicity against U251 and C6 glioblastoma cells. In general, all tested 2-pyrrolinones with two vicinalphenyl rings were more active than those without this structural moiety, and 1-butyl-5-methyl-5-(2-oxopropyl)-3,4-diphenyl-1,5-dihydro-2H-pyrrol-2-one was the most cytotoxic and appears to be a newpossibility as an antitumor scaffold to this aggressive brain tumor
DOI: 10.6084/m9.figshare.5896771.v1
title: One-Step Synthesis of 3,4-Diphenyl-2-pyrrolinones by Solvent-Free and Bi2O3-Catalyzed Approaches and Cytotoxicity Screening Against Glioma Cells.pdf

description: Multifunctionalized 2-pyrrolinones were synthesized from the formal aza-[3 + 2] cycloaddition reactionof acyclic enaminones and diphenylcyclopropenone. For primary enaminones, solventless reaction undermicrowave heating was developed. On the other hand, catalysis by Bi2O3under conventional heating wasthe more suitable strategy when secondary enaminones were employed. These conditions allowed thesynthesis of a set of 2-pyrrolinones with two vicinal phenyl substituents, which were evaluated forcytotoxicity against U251 and C6 glioblastoma cells. In general, all tested 2-pyrrolinones with two vicinalphenyl rings were more active than those without this structural moiety, and 1-butyl-5-methyl-5-(2-oxopropyl)-3,4-diphenyl-1,5-dihydro-2H-pyrrol-2-one was the most cytotoxic and appears to be a newpossibility as an antitumor scaffold to this aggressive brain tumor
DOI: 10.6084/m9.figshare.5896759
title: A new rhynchosaur maxillary tooth plate morphotype expands the disparity of the group in the Ischigualasto Formation (Late Triassic) of Northwestern Argentina

description: Rhynchosaurs are a clade of quadruped, herbivorous stem-archosaur diapsids restricted to the Triassic Period. The group became globally distributed and the numerically dominant tetrapods of several terrestrial ecosystems before their extinction. Derived rhynchosaurs are characterized by a specialized masticatory apparatus, composed of a blade-and-groove occlusion with multiple longitudinal maxillary tooth rows. The morphology of the maxillary tooth plate has shown to be taxonomically and phylogenetically informative. So far, two rhynchosaur maxillary tooth plate morphotypes are known in Argentina, one belonging to an unnamed stenaulorhynchine from the Chañares Formation and the other to the hyperodapedontine <i>Hyperodapedon sanjuanensis</i>, the single rhynchosaur species currently name for the Ischigualasto Formation. Here we describe a new rhynchosaur maxillary tooth plate morphotype based on an indeterminate hyperodapedontine specimen from the Ischigualasto Formation. This maxillary tooth plate (PVL 2728) possesses a single longitudinal groove that divides symmetric lateral and medial tooth-bearing areas with relatively large tooth crowns, which is an uncommon combination of features among hyperodapedontines. These qualitative observations in addition to quantitative analyses show that the morphology of PVL 2728 differs from that of, at least, other sampled South American rhynchosaurs. Therefore, this specimen expands the morphological disparity of rhynchosaurs in northwest Argentina and southwestern Pangaea.
DOI: 10.6084/m9.figshare.5896759.v2
title: A new rhynchosaur maxillary tooth plate morphotype expands the disparity of the group in the Ischigualasto Formation (Late Triassic) of Northwestern Argentina

description: Rhynchosaurs are a clade of quadruped, herbivorous stem-archosaur diapsids restricted to the Triassic Period. The group became globally distributed and the numerically dominant tetrapods of several terrestrial ecosystems before their extinction. Derived rhynchosaurs are characterized by a specialized masticatory apparatus, composed of a blade-and-groove occlusion with multiple longitudinal maxillary tooth rows. The morphology of the maxillary tooth plate has shown to be taxonomically and phylogenetically informative. So far, two rhynchosaur maxillary tooth plate morphotypes are known in Argentina, one belonging to an unnamed stenaulorhynchine from the Chañares Formation and the other to the hyperodapedontine <i>Hyperodapedon sanjuanensis</i>, the single rhynchosaur species currently name for the Ischigualasto Formation. Here we describe a new rhynchosaur maxillary tooth plate morphotype based on an indeterminate hyperodapedontine specimen from the Ischigualasto Formation. This maxillary tooth plate (PVL 2728) possesses a single longitudinal groove that divides symmetric lateral and medial tooth-bearing areas with relatively large tooth crowns, which is an uncommon combination of features among hyperodapedontines. These qualitative observations in addition to quantitative analyses show that the morphology of PVL 2728 differs from that of, at least, other sampled South American rhynchosaurs. Therefore, this specimen expands the morphological disparity of rhynchosaurs in northwest Argentina and southwestern Pangaea.
DOI: 10.6084/m9.figshare.5896759.v1
title: A new rhynchosaur maxillary tooth plate morphotype expands the disparity of the group in the Ischigualasto Formation (Late Triassic) of Northwestern Argentina

description: Rhynchosaurs are a clade of quadruped, herbivorous stem-archosaur diapsids restricted to the Triassic Period. The group became globally distributed and the numerically dominant tetrapods of several terrestrial ecosystems before their extinction. Derived rhynchosaurs are characterized by a specialized masticatory apparatus, composed of a blade-and-groove occlusion with multiple longitudinal maxillary tooth rows. The morphology of the maxillary tooth plate has shown to be taxonomically and phylogenetically informative. So far, two rhynchosaur maxillary tooth plate morphotypes are known in Argentina, one belonging to an unnamed stenaulorhynchine from the Chañares Formation and the other to the hyperodapedontine <i>Hyperodapedon sanjuanensis</i>, the single rhynchosaur species currently name for the Ischigualasto Formation. Here we describe a new rhynchosaur maxillary tooth plate morphotype based on an indeterminate hyperodapedontine specimen from the Ischigualasto Formation. This maxillary tooth plate (PVL 2728) possesses a single longitudinal groove that divides symmetric lateral and medial tooth-bearing areas with relatively large tooth crowns, which is an uncommon combination of features among hyperodapedontines. These qualitative observations in addition to quantitative analyses show that the morphology of PVL 2728 differs from that of, at least, other sampled South American rhynchosaurs. Therefore, this specimen expands the morphological disparity of rhynchosaurs in northwest Argentina and southwestern Pangaea.
DOI: 10.6084/m9.figshare.5896753
title: Input data for the joint model of the Apple proliferation disease

description: The file contains the data set used to fit the joint model for the Apple proliferation disease. The data set includes data on environment, vector, pathogen and AP symptoms of apple trees.
DOI: 10.6084/m9.figshare.5896753.v1
title: Input data for the joint model of the Apple proliferation disease

description: The file contains the data set used to fit the joint model for the Apple proliferation disease. The data set includes data on environment, vector, pathogen and AP symptoms of apple trees.
DOI: 10.6084/m9.figshare.5896750
title: Home Range Utilization by Chacma Baboon (Papio ursinus) Troops on Suikerbosrand Nature Reserve, South Africa

description: Secondary data was used to determine the home range sizes and seasonal movements of 10 troops of baboons on Suikerbosrand Nature Reserve in South Africa. Data originated from GPS tracking collars that were fitted to one female baboon in each of 10 troops.
DOI: 10.6084/m9.figshare.5896708
title: Transcripts of interviews with 4 participants regarding Vicarious Liability in the SMME workplace

description: This is a collection of transcripts of interviews with four voluntary participants for the dissertation submitted in partial fulfillment of an MPhil specialising in Digital Curation at the University of Cape Town.<br>Title of the dissertation:Measuring the Effect of Vicarious Liability under POPI Implementation within SMMEs
DOI: 10.6084/m9.figshare.5896708.v1
title: Estate Manager Transcript.doc.docx

description: This is an interview dataset.
DOI: 10.6084/m9.figshare.5896627
title: 100SPARQLgold_adequate_source_target.txt

description: # SPARQLQuerySetPlease, if you want to use this query set please contact:<br>Isabel.torre@tecnalia.com
DOI: 10.6084/m9.figshare.5896627.v1
title: 100SPARQLgold_adequate_source_target.txt

description: # SPARQLQuerySetPlease, if you want to use this query set please contact:<br>Isabel.torre@tecnalia.com
DOI: 10.6084/m9.figshare.5896621
title: Supplementary Material for: Low Skeletal Muscle Density Is Associated with Early Death in Patients with Perihilar Cholangiocarcinoma Regardless of Subsequent Treatment

description: <b><i>Background:</i></b> Low skeletal muscle mass is associated with increased postoperative morbidity and worse survival following resection for perihilar cholangiocarcinoma (PHC). We investigated the predictive value of skeletal muscle mass and density for overall survival (OS) of all patients with suspected PHC, regardless of treatment. <b><i>Methods:</i></b> Baseline characteristics and parameters regarding disease and treatment were collected from all patients with PHC from 2002 to 2014. Skeletal muscle mass and density were measured at the level of the third lumbar vertebra on CT. The association between skeletal muscle mass and density with OS was investigated using the Kaplan-Meier method and Cox survival. <b><i>Results:</i></b> Median OS in 233 included patients did not differ between those with and without low skeletal muscle mass (<i>p</i> = 0.203), whereas a significantly different median OS (months) was observed between patients with low (HR 7.0, 95% CI 4.7–9.3) and high (HR 12.1, 95% CI 8.1–16.1) skeletal muscle density (<i>p</i> = 0.004). Low skeletal muscle density was independently associated with decreased OS (HR 1.78, 95% CI 1.03–3.07, <i>p</i> = 0.040) within the first 6 months but not after 6 months (HR 0.68, 95% CI 0.44–1.07, <i>p</i> = 0.093), after adjusting for age, tumour size and suspected peritoneal or other distant metastases on imaging. <b><i>Conclusion:</i></b> A time-dependent effect of skeletal muscle density on OS was found in patients with PHC, regardless of subsequent treatment. Low skeletal muscle density may identify patients at risk for early death.
DOI: 10.6084/m9.figshare.5896621.v1
title: Supplementary Material for: Low Skeletal Muscle Density Is Associated with Early Death in Patients with Perihilar Cholangiocarcinoma Regardless of Subsequent Treatment

description: <b><i>Background:</i></b> Low skeletal muscle mass is associated with increased postoperative morbidity and worse survival following resection for perihilar cholangiocarcinoma (PHC). We investigated the predictive value of skeletal muscle mass and density for overall survival (OS) of all patients with suspected PHC, regardless of treatment. <b><i>Methods:</i></b> Baseline characteristics and parameters regarding disease and treatment were collected from all patients with PHC from 2002 to 2014. Skeletal muscle mass and density were measured at the level of the third lumbar vertebra on CT. The association between skeletal muscle mass and density with OS was investigated using the Kaplan-Meier method and Cox survival. <b><i>Results:</i></b> Median OS in 233 included patients did not differ between those with and without low skeletal muscle mass (<i>p</i> = 0.203), whereas a significantly different median OS (months) was observed between patients with low (HR 7.0, 95% CI 4.7–9.3) and high (HR 12.1, 95% CI 8.1–16.1) skeletal muscle density (<i>p</i> = 0.004). Low skeletal muscle density was independently associated with decreased OS (HR 1.78, 95% CI 1.03–3.07, <i>p</i> = 0.040) within the first 6 months but not after 6 months (HR 0.68, 95% CI 0.44–1.07, <i>p</i> = 0.093), after adjusting for age, tumour size and suspected peritoneal or other distant metastases on imaging. <b><i>Conclusion:</i></b> A time-dependent effect of skeletal muscle density on OS was found in patients with PHC, regardless of subsequent treatment. Low skeletal muscle density may identify patients at risk for early death.
DOI: 10.6084/m9.figshare.5896534
title: Babic_Sencar_original_ data.xlsx

description: Original data going together with the manuscript 'Fingerprints of solar activity in ground level environmental radioactivity' by D. Babić and J. Senčar, submitted to the Proceedings of the Royal Society A<br>
DOI: 10.6084/m9.figshare.5896534.v1
title: Babic_Sencar_original_ data.xlsx

description: Original data going together with the manuscript 'Fingerprints of solar activity in ground level environmental radioactivity' by D. Babić and J. Senčar, submitted to the Proceedings of the Royal Society A<br>
DOI: 10.6084/m9.figshare.5896498
title: Supplementary Material for: A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury

description: <b><i>Background:</i></b> β-Adrenergic agents suppress inflammation and may play an important role in posttraumatic infections. Mechanisms may include inhibition of MAP kinase signaling. We sought to determine whether MKP-1 contributed to catecholamine suppression of innate immunity and also wanted to know whether early catecholamine treatment after traumatic injury increases the risk of later nosocomial infection. <b><i>Methods:</i></b> We performed experiments using THP-1 cells and peripheral blood mononuclear cells from healthy individuals. We exposed cells to epinephrine and/or LPS and measured inflammatory gene transcription and MAP kinase activation. We inhibited MKP-1 activity to determine its role in catecholamine-induced immune suppression. Finally, we studied injured subjects to determine whether early catecholamine treatment was associated with nosocomial infection. <b><i>Results:</i></b> Epinephrine increases MKP-1 transcripts and protein and decreases LPS-induced p38 and JNK phosphorylation and TNF-α gene transcription. RNAi inhibition of MKP-1 at least partially restores LPS-induced TNF-α gene expression (<i>p</i> = 0.024). In the clinical cohort, subjects treated with β-adrenergic agents had an increased risk of ventilator-associated pneumonia (aOR = 1.9; 95% CI = 1.3–2.6) and bacteremia (aOR = 1.5; 95% CI = 1.1–2.3). <b><i>Conclusions:</i></b> MKP-1 may have a role in catecholamine-induced suppression of innate immunity, and exogenous catecholamines might contribute to nosocomial infection risk.
DOI: 10.6084/m9.figshare.5896498.v1
title: Supplementary Material for: A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury

description: <b><i>Background:</i></b> β-Adrenergic agents suppress inflammation and may play an important role in posttraumatic infections. Mechanisms may include inhibition of MAP kinase signaling. We sought to determine whether MKP-1 contributed to catecholamine suppression of innate immunity and also wanted to know whether early catecholamine treatment after traumatic injury increases the risk of later nosocomial infection. <b><i>Methods:</i></b> We performed experiments using THP-1 cells and peripheral blood mononuclear cells from healthy individuals. We exposed cells to epinephrine and/or LPS and measured inflammatory gene transcription and MAP kinase activation. We inhibited MKP-1 activity to determine its role in catecholamine-induced immune suppression. Finally, we studied injured subjects to determine whether early catecholamine treatment was associated with nosocomial infection. <b><i>Results:</i></b> Epinephrine increases MKP-1 transcripts and protein and decreases LPS-induced p38 and JNK phosphorylation and TNF-α gene transcription. RNAi inhibition of MKP-1 at least partially restores LPS-induced TNF-α gene expression (<i>p</i> = 0.024). In the clinical cohort, subjects treated with β-adrenergic agents had an increased risk of ventilator-associated pneumonia (aOR = 1.9; 95% CI = 1.3–2.6) and bacteremia (aOR = 1.5; 95% CI = 1.1–2.3). <b><i>Conclusions:</i></b> MKP-1 may have a role in catecholamine-induced suppression of innate immunity, and exogenous catecholamines might contribute to nosocomial infection risk.
DOI: 10.6084/m9.figshare.5896492
title: Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies?

description: <b>Introduction</b>: Approved medications for relapsing-remitting multiple sclerosis have shown to be effective in terms of their anti-inflammatory potential. However, it is also crucial to evaluate what long-term effects a patient can expect from current MS drugs in terms of preventing neurodegeneration. Here we aim to provide an overview of the current treatment strategies in MS with a specific focus on potential neuroprotective effects. <b>Areas covered</b>: Randomized, double-blind and placebo or referral-drug controlled phase 2a/b and phase 3 trials were examined; non-blinded phase 4 studies (extension studies) were included to provide long-term data, if not otherwise available. Endpoints considered were expanded disability status scale, various neuropsychological tests, percent brain volume change and T1-hypointense lesions as well as multiple sclerosis functional composite, confirmed disease progression, and no evidence of disease activity. <b>Expert commentary</b>: Overall, neuroprotective functions of classical MS therapeutics are not sufficiently investigated, but available data show limited effects. Thus, further research and development in neuroprotection are warranted. When counselling patients, potential long-term beneficial effects should be presented more conservatively.
DOI: 10.6084/m9.figshare.5896492.v1
title: Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies?

description: <b>Introduction</b>: Approved medications for relapsing-remitting multiple sclerosis have shown to be effective in terms of their anti-inflammatory potential. However, it is also crucial to evaluate what long-term effects a patient can expect from current MS drugs in terms of preventing neurodegeneration. Here we aim to provide an overview of the current treatment strategies in MS with a specific focus on potential neuroprotective effects. <b>Areas covered</b>: Randomized, double-blind and placebo or referral-drug controlled phase 2a/b and phase 3 trials were examined; non-blinded phase 4 studies (extension studies) were included to provide long-term data, if not otherwise available. Endpoints considered were expanded disability status scale, various neuropsychological tests, percent brain volume change and T1-hypointense lesions as well as multiple sclerosis functional composite, confirmed disease progression, and no evidence of disease activity. <b>Expert commentary</b>: Overall, neuroprotective functions of classical MS therapeutics are not sufficiently investigated, but available data show limited effects. Thus, further research and development in neuroprotection are warranted. When counselling patients, potential long-term beneficial effects should be presented more conservatively.