cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5793705.v1
title: New molecular features of cowpea bean (<i>Vigna unguiculata</i>, l. Walp) β-vignin

description: Cowpea seed β-vignin, a vicilin-like globulin, proved to exert various health favourable effects, including blood cholesterol reduction in animal models. The need of a simple scalable enrichment procedure for further studies for tailored applications of this seed protein is crucial. A chromatography-independent fractionation method allowing to obtain a protein preparation with a high degree of homogeneity was used. Further purification was pursued to deep the molecular characterisation of β-vignin. The results showed: (i) differing glycosylation patterns of the two constituent polypeptides, in agreement with amino acid sequence features; (ii) the seed accumulation of a gene product never identified before; (iii) metal binding capacity of native protein, a property observed only in few other legume seed vicilins. Using a shorted protocol, -vignin with a high degree of purity was obtain. A glycolylated gene product, never identified before, and its metal binding capacity were identified.
DOI: 10.6084/m9.figshare.5793699
title: Brodalumab for the Treatment of Psoriasis: A Review of Phase III Trials

description: Article full textThe full text of this article can be found at http://link.springer.com/article/10.1007/s13555-016-0121-x.Provide enhanced content for this articleIf you are an author of this publication and would like to provide additional enhanced content for your article then please contact adisrapidplus@springer.com.The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.Other enhanced features include, but are not limited to:Slide decksVideos and animationsAudio abstractsAudio slides
DOI: 10.6084/m9.figshare.5793699.v1
title: Brodalumab for the Treatment of Psoriasis: A Review of Phase III Trials

description: Article full textThe full text of this article can be found at http://link.springer.com/article/10.1007/s13555-016-0121-x.Provide enhanced content for this articleIf you are an author of this publication and would like to provide additional enhanced content for your article then please contact adisrapidplus@springer.com.The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.Other enhanced features include, but are not limited to:Slide decksVideos and animationsAudio abstractsAudio slides
DOI: 10.6084/m9.figshare.5793693
title: Supplementary Material for: Risk Factors and Clinical Features in Cashew Nut Oral Food Challenges

description: <b><i>Background:</i></b> Cashew nuts (CN) are capable of causing severe allergic reactions. However, little has been reported about the details of CN oral food challenges (OFC). <b><i>Methods:</i></b> CN-specific IgE (sIgE) levels were measured for 1 year in 66 patients who underwent an OFC with &gt;3 g CN for diagnosis or confirmation of tolerance acquisition between June 2006 and August 2014. We retrospectively analyzed the OFC and patient background. <b><i>Results:</i></b> The median (IQR) age of the 66 patients (48 boys/men and 18 girls/women) was 7.0 years (5.7-8.8). Twelve patients (18.2%) had a positive OFC result; 6 of 8 (75%) patients with a history of an immediate reaction to CN failed the OFC. Anaphylaxis was experienced by 5 of these 12 (42%) patients. A history of an immediate reaction to CN and the CN sIgE levels were significantly different for patients with a positive or negative OFC result (<i>p</i> &lt; 0.01). Among patients without a previous immediate reaction to CN, the 95% positive predictive value (PPV) for the CN sIgE level for a positive OFC result was 66.1 kU<sub>A</sub>/L. <b><i>Conclusions:</i></b> A history of an immediate reaction to CN and high CN sIgE were risk factors for a positive OFC result. The number of positive OFC results was relatively low, but there was a high probability of anaphylaxis. We should consider the indication of OFC carefully for patients with a history of immediate reactions to CN and avoid OFC for patients without such a history whose CN sIgE values are &gt;66.1 kU<sub>A</sub>/L (95% PPV).
DOI: 10.6084/m9.figshare.5793693.v1
title: Supplementary Material for: Risk Factors and Clinical Features in Cashew Nut Oral Food Challenges

description: <b><i>Background:</i></b> Cashew nuts (CN) are capable of causing severe allergic reactions. However, little has been reported about the details of CN oral food challenges (OFC). <b><i>Methods:</i></b> CN-specific IgE (sIgE) levels were measured for 1 year in 66 patients who underwent an OFC with &gt;3 g CN for diagnosis or confirmation of tolerance acquisition between June 2006 and August 2014. We retrospectively analyzed the OFC and patient background. <b><i>Results:</i></b> The median (IQR) age of the 66 patients (48 boys/men and 18 girls/women) was 7.0 years (5.7-8.8). Twelve patients (18.2%) had a positive OFC result; 6 of 8 (75%) patients with a history of an immediate reaction to CN failed the OFC. Anaphylaxis was experienced by 5 of these 12 (42%) patients. A history of an immediate reaction to CN and the CN sIgE levels were significantly different for patients with a positive or negative OFC result (<i>p</i> &lt; 0.01). Among patients without a previous immediate reaction to CN, the 95% positive predictive value (PPV) for the CN sIgE level for a positive OFC result was 66.1 kU<sub>A</sub>/L. <b><i>Conclusions:</i></b> A history of an immediate reaction to CN and high CN sIgE were risk factors for a positive OFC result. The number of positive OFC results was relatively low, but there was a high probability of anaphylaxis. We should consider the indication of OFC carefully for patients with a history of immediate reactions to CN and avoid OFC for patients without such a history whose CN sIgE values are &gt;66.1 kU<sub>A</sub>/L (95% PPV).
DOI: 10.6084/m9.figshare.5793687
title: Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation

description: ABSTRACT Aims: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. Material and Methods: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP. Case group (group-2) was further classified into: Category 2A (patients not on catheter) and category 2B (patients on catheter). All relevant clinical parameters like IPSS, prostate size, Qmax, PVR were recorded. Cystoscopy and bladder biopsy were performed in all patients. Various ultrastructural parameters like myocytes, fascicular pattern, interstitial tissue, nerve hypertrophy and cell junction pattern were analyzed under electron microscope and they were clinically correlated using appropriate statistical tests. Results: Control group had significant difference as compared to case group in terms of baseline parameters like IPSS, flow rate and prostate size, both preoperatively and postoperatively, except for PVR, which was seen only preoperatively. There was statistically significant difference in ultrastructural patterns between case and control group in all five electron microscopic patterns. However, no significant difference was found between the subcategories of case groups. Conclusions: BPE is responsible for ultra structural changes in detrusor muscle and these changes remain persistent even after TURP. Nerve hypertrophy, which was not thoroughly discussed in previous studies, is also one of the salient feature of this study.
DOI: 10.6084/m9.figshare.5793687.v1
title: Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation

description: ABSTRACT Aims: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. Material and Methods: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP. Case group (group-2) was further classified into: Category 2A (patients not on catheter) and category 2B (patients on catheter). All relevant clinical parameters like IPSS, prostate size, Qmax, PVR were recorded. Cystoscopy and bladder biopsy were performed in all patients. Various ultrastructural parameters like myocytes, fascicular pattern, interstitial tissue, nerve hypertrophy and cell junction pattern were analyzed under electron microscope and they were clinically correlated using appropriate statistical tests. Results: Control group had significant difference as compared to case group in terms of baseline parameters like IPSS, flow rate and prostate size, both preoperatively and postoperatively, except for PVR, which was seen only preoperatively. There was statistically significant difference in ultrastructural patterns between case and control group in all five electron microscopic patterns. However, no significant difference was found between the subcategories of case groups. Conclusions: BPE is responsible for ultra structural changes in detrusor muscle and these changes remain persistent even after TURP. Nerve hypertrophy, which was not thoroughly discussed in previous studies, is also one of the salient feature of this study.
DOI: 10.6084/m9.figshare.5793684
title: Water basin management plan integrated in spatial plans in Scotland

description: ABSTRACT The Water Directive 2000/60/EC regards the water basin management plans integrated in spatial plans in the European community, affecting the regional and local planning. In Scotland, the Strategic Environmental Assessment is used to combine distinct sectors and planning scales. This paper compared the procedures and steps of spatial planning for the same area: Scottish River Basin Management Plan 2009/2015 and Local Development Plan for Glasgow 2010/2015, with their Strategic Environmental Assessment as well. As a result, features of each planning tools affect the aims and details of Strategic Environmental Assessment, which conducts gradually the planning integration. The practice of Strategic Environmental Assessment is useful regarding the Water Directive objectives.
DOI: 10.6084/m9.figshare.5793684.v1
title: Water basin management plan integrated in spatial plans in Scotland

description: ABSTRACT The Water Directive 2000/60/EC regards the water basin management plans integrated in spatial plans in the European community, affecting the regional and local planning. In Scotland, the Strategic Environmental Assessment is used to combine distinct sectors and planning scales. This paper compared the procedures and steps of spatial planning for the same area: Scottish River Basin Management Plan 2009/2015 and Local Development Plan for Glasgow 2010/2015, with their Strategic Environmental Assessment as well. As a result, features of each planning tools affect the aims and details of Strategic Environmental Assessment, which conducts gradually the planning integration. The practice of Strategic Environmental Assessment is useful regarding the Water Directive objectives.
DOI: 10.6084/m9.figshare.5793681
title: Bacterial cellulose nanocrystals: from obtaining, under different hydrolysis conditions, the incorporation as reinforcement in poly(L-lactic acid)

description: ABSTRACT This work aimed to produce bacterial cellulose, to obtain bacterial cellulose nanocrystals, to incorporate nanocrystals as a reinforcement in poly(L-lactic acid) and to evaluate the properties of these bionanocomposites. Bacterial cellulose membranes from the bacterium Gluconacetobacter hansenii were produced. From the membranes were obtained nanocrystals by hydrolysis with sulfuric acid (H2SO4), based on 11 experiments. The parameters varied in the experiments were: concentration of H2SO4, temperature and time. It is possible to define criteria for obtaining nanocrystals by thermogravimetric analysis and analysis of dynamic scattering of light. Main results indicate the possibility of obtaining in the condition of: 80% concentration of H2SO4 (m/m), 60 °C and 60 min. For this condition, suitable sizes of the nanocrystals (mean 388 nm), suitable zeta potential (-38 mV) and adequate thermal stability (Tonset2 = 301.9 °C) were obtained. Subsequently, nanocrystals obtained according to defined criteria were incorporated into poly(L-lactic acid) in two concentrations (2,5 and 5%), using two methods (without and with functionalization of nanocrystals). The prepared bionanocomposites were characterized by thermogravimetric analysis and differential explanatory calorimetry. Results of the techniques of characterization of bionanocomposites were compared with results of pure poly(L-lactic acid). Main results regarding the methods, reveal the importance of the functionalization of the nanocrystals before incorporating them to the poly(L-lactic acid). On the reinforcement concentration used, the increase of the thermal stability was gradual, according to reinforcement content, and for the bionanocomposite with 5% functionalized nanocrystals the increase was of 10,4 ºC in the Tonset2 in relation to the poly(L-lactic acid) pure. However, the degree of crystallinity decreased (Xc of pure PLLA = 40,38% and Xc of bionanocomposite with 5% of functionalized nanocrystals = 24,73%). It is concluded that the addition of bacterial cellulose nanocrystals in poly(L-lactic acid) is environmentally feasible and improves properties.
DOI: 10.6084/m9.figshare.5793681.v1
title: Bacterial cellulose nanocrystals: from obtaining, under different hydrolysis conditions, the incorporation as reinforcement in poly(L-lactic acid)

description: ABSTRACT This work aimed to produce bacterial cellulose, to obtain bacterial cellulose nanocrystals, to incorporate nanocrystals as a reinforcement in poly(L-lactic acid) and to evaluate the properties of these bionanocomposites. Bacterial cellulose membranes from the bacterium Gluconacetobacter hansenii were produced. From the membranes were obtained nanocrystals by hydrolysis with sulfuric acid (H2SO4), based on 11 experiments. The parameters varied in the experiments were: concentration of H2SO4, temperature and time. It is possible to define criteria for obtaining nanocrystals by thermogravimetric analysis and analysis of dynamic scattering of light. Main results indicate the possibility of obtaining in the condition of: 80% concentration of H2SO4 (m/m), 60 °C and 60 min. For this condition, suitable sizes of the nanocrystals (mean 388 nm), suitable zeta potential (-38 mV) and adequate thermal stability (Tonset2 = 301.9 °C) were obtained. Subsequently, nanocrystals obtained according to defined criteria were incorporated into poly(L-lactic acid) in two concentrations (2,5 and 5%), using two methods (without and with functionalization of nanocrystals). The prepared bionanocomposites were characterized by thermogravimetric analysis and differential explanatory calorimetry. Results of the techniques of characterization of bionanocomposites were compared with results of pure poly(L-lactic acid). Main results regarding the methods, reveal the importance of the functionalization of the nanocrystals before incorporating them to the poly(L-lactic acid). On the reinforcement concentration used, the increase of the thermal stability was gradual, according to reinforcement content, and for the bionanocomposite with 5% functionalized nanocrystals the increase was of 10,4 ºC in the Tonset2 in relation to the poly(L-lactic acid) pure. However, the degree of crystallinity decreased (Xc of pure PLLA = 40,38% and Xc of bionanocomposite with 5% of functionalized nanocrystals = 24,73%). It is concluded that the addition of bacterial cellulose nanocrystals in poly(L-lactic acid) is environmentally feasible and improves properties.
DOI: 10.6084/m9.figshare.5793678
title: Selection of rice genotypes to integrate a varietal mixture for blast control

description: ABSTRACT Blast, caused by Magnaporthe oryzae (Herbert) Barr, is one of the most important diseases affecting the rice crop. Several strategies for the disease management, such as use of resistant genotypes, have been adopted; however, the large number of pathogen races makes difficult to obtain cultivars of durable resistance. In this context, using a varietal mixture may be a viable and promising strategy for the disease control. Thus, the aim of this study was to evaluate the reaction of rice cultivars to M. oryzae races and the efficiency of the varietal mixture in reducing the severity of blast under lowland and upland conditions in Tocantins State. To evaluate the efficiency of the varietal mixture, 37 genotypes were sown in isolated lines and in mixture. The severity of leaf blast was evaluated over the crop cycle, as well as the incidence of panicle blast and the crop yield. There was variation in the reaction of the studied genotypes to the major inoculated races. The rice composition was effective in reducing blast severity on leaves and panicles and showed an increase in productivity under both lowland and upland conditions.
DOI: 10.6084/m9.figshare.5793678.v1
title: Selection of rice genotypes to integrate a varietal mixture for blast control

description: ABSTRACT Blast, caused by Magnaporthe oryzae (Herbert) Barr, is one of the most important diseases affecting the rice crop. Several strategies for the disease management, such as use of resistant genotypes, have been adopted; however, the large number of pathogen races makes difficult to obtain cultivars of durable resistance. In this context, using a varietal mixture may be a viable and promising strategy for the disease control. Thus, the aim of this study was to evaluate the reaction of rice cultivars to M. oryzae races and the efficiency of the varietal mixture in reducing the severity of blast under lowland and upland conditions in Tocantins State. To evaluate the efficiency of the varietal mixture, 37 genotypes were sown in isolated lines and in mixture. The severity of leaf blast was evaluated over the crop cycle, as well as the incidence of panicle blast and the crop yield. There was variation in the reaction of the studied genotypes to the major inoculated races. The rice composition was effective in reducing blast severity on leaves and panicles and showed an increase in productivity under both lowland and upland conditions.
DOI: 10.6084/m9.figshare.5793675
title: Isotonic sports drink promotes rehydration and decreases proteinuria following karate training

description: Abstract Introduction: Adequate hydration status in the sport is essential for good health, yet the relationship between hydration, proteinuria and sports is little studied. Objective: To analyze the influence of an isotonic sports drink as rehydration strategy on the hydration status and proteinuria after karate training. Methods: Ten athletes participated in this study. In the first session of standard training, called observation training session (STO), the athletes hydrated themselves according to their habits, and in the second session of standard training, called nutritional intervention training session (STIN), an ideal practice of hydration protocol was followed, using an isotonic sports drink as a rehydration liquid during the training. The hydration status was verified by monitoring the body weight before and after training, the urine specific gravity pre-and post-training and the urine volume post-training. To observe the influence of practice of hydration on the renal function post exercise proteinuria was measured. Results: We observed a statistically significant difference in urine density between the samples pre- and post-exercise only on STIN (p = 0.047). When we compare the sessions, there was a lower variation in body weight (p = 0.011) and higher urinary volume (p &lt; 0.001), on nutritional intervention training. In STO, there was a higher percentage of athletes who showed proteinuria (70%) compared to the STIN (50%) in the urine sample after training. Conclusion: The use of isotonic sports drink as practice of hydration by karate athletes promoted rehydration during one session of training and reduce post-training proteinuria.
DOI: 10.6084/m9.figshare.5793675.v1
title: Isotonic sports drink promotes rehydration and decreases proteinuria following karate training

description: Abstract Introduction: Adequate hydration status in the sport is essential for good health, yet the relationship between hydration, proteinuria and sports is little studied. Objective: To analyze the influence of an isotonic sports drink as rehydration strategy on the hydration status and proteinuria after karate training. Methods: Ten athletes participated in this study. In the first session of standard training, called observation training session (STO), the athletes hydrated themselves according to their habits, and in the second session of standard training, called nutritional intervention training session (STIN), an ideal practice of hydration protocol was followed, using an isotonic sports drink as a rehydration liquid during the training. The hydration status was verified by monitoring the body weight before and after training, the urine specific gravity pre-and post-training and the urine volume post-training. To observe the influence of practice of hydration on the renal function post exercise proteinuria was measured. Results: We observed a statistically significant difference in urine density between the samples pre- and post-exercise only on STIN (p = 0.047). When we compare the sessions, there was a lower variation in body weight (p = 0.011) and higher urinary volume (p &lt; 0.001), on nutritional intervention training. In STO, there was a higher percentage of athletes who showed proteinuria (70%) compared to the STIN (50%) in the urine sample after training. Conclusion: The use of isotonic sports drink as practice of hydration by karate athletes promoted rehydration during one session of training and reduce post-training proteinuria.