cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7101599.v1
title: New insight on the relationship between lethal electrical fields versus cardiomyocyte orientation

description: Abstract Introduction Cardiovascular diseases represent a major cause of death world-wide and one of their greatest complications is the development of cardiac arrhythmias, in which ventricular fibrillation (VF) stands out as the most severe one. The only therapy that reverses VF is defibrillation. However defibrillatory shock is capable of killing heart cells and it is known that the orientation of the cell major axis with respect to the electrical field (E) direction is a determining factor for cellular excitation and injury, which is leading to the development of new defibrillation protocols. The aim of this work is to fill the gap in information about cell lethality for intermediate cell orientation angles. Methods Ventricular myocytes were extracted from adult male Wistar rats and the cells were plated in a chamber for perfusion and stimulation with bipolar voltage pulses to determine the stimulation threshold (ET). Then, monopolar stimulus was applied and amplitude was increased until cell lethal injury. This protocol was performed on four experimental groups: cells oriented at 0°, 30°, 60° and 90°, with respect to E direction. Results 87 cells were analyzed and an increase in amplitude of E associated with 50% lethality (E50) was verified as the direction of E application and cell major axis orientation departed. Conclusion Taken the same probability of lethality, our data suggest a nonlinear increase of E amplitude from 0° to 90° similar to that of ET. These in-between data had not yet been shown and are important for service-based future defibrillation protocols.
DOI: 10.6084/m9.figshare.7101593.v1
title: Adjustable versus non-adjustable suture techniques for concomitant horizontal strabismus: a comparative study

description: ABSTRACT Purpose: To compare the surgical results of adjustable and non-adjustable horizontal strabismus surgery for concomitant horizontal strabismus. Methods: The charts of 231 patients, who underwent horizontal strabismus surgery, selected using probabilistic sampling, were retrospectively reviewed. Patients were divided into two groups according to the surgical technique used and strabismus type. The adjustable suture technique was used for 107 patients (Group 1), and non-adjustable or conventional surgery was performed in the remaining 124 patients (Group 2). Patients with esotropia (ET) or exotropia (XT) of &lt;55 prism diopters (PD) at distance were included. The following exclusion criteria were applied: all intermittent or vertical deviations, anisotropias &gt;5 PD, syndromes, restrictive or paretic strabismus, reoperations, botulinum toxin injection, and patients postoperatively followed up for &lt;3 months. Surgical success was set to a range between orthotropia and an esodeviation of up to 10 PD for both ET and XT. Results: An amblyopia rate &gt;50% was present in all subgroups. Significant differences between strabismus groups submitted to adjustable technique and non-adjustable on postoperative day 1 were observed (p=0.00 for ET and p=0.01 for XT) and at the last visit for the XT group with a follow-up of at least 1 year (p=0.05). Conclusion: The adjustable suture technique produced a higher success rate than non-adjustable strabismus surgery for both ET and XT groups on postoperative day 1. For XT patients, the adjustable suture technique appears to produce better surgical results than non-adjustable surgery, when the surgical goal is long-lasting maintenance of a small hypercorrection.
DOI: 10.6084/m9.figshare.7101587
title: Assessment of social disablement among individuals living in therapeutic residential services in a small municipality of Rio de Janeiro state

description: Abstract Background Knowledge about the extent of social disablement among people with severe mental disorders living in therapeutic residential services is crucial for policy makers and mental health professionals involved in the delivery of community-base care. A cross-sectional study was conducted with people living in therapeutic residential services in the municipality of Carmo, Rio de Janeiro state, Brazil. Objective Evaluate limitations of the social behavior of the interviewees through the Social Behavior Scale (SBS). Method Data were collected between January and February 2017 using the SBS. Results The sample was composed mostly of men from Rio de Janeiro state, with mean age of 60.4 years, illiterate, benefit recipients, with schizophrenia and other psychotic disorders and a long period of previous hospitalization with no contact with their families. Approximately 96% of them showed at least one social behavior problem, often related to poor self-care, little spontaneous communication (Does the person start a conversation?), slowness, laughing and talking to self, and other problems (any other behavior or attitude not previously specified that seem to be delaying the progress of the person). Conclusion This population presented high frequency of social disablement that may prevent their social reintegration, evidencing the need for implementing social rehabilitation programs.
DOI: 10.6084/m9.figshare.7101587.v1
title: Assessment of social disablement among individuals living in therapeutic residential services in a small municipality of Rio de Janeiro state

description: Abstract Background Knowledge about the extent of social disablement among people with severe mental disorders living in therapeutic residential services is crucial for policy makers and mental health professionals involved in the delivery of community-base care. A cross-sectional study was conducted with people living in therapeutic residential services in the municipality of Carmo, Rio de Janeiro state, Brazil. Objective Evaluate limitations of the social behavior of the interviewees through the Social Behavior Scale (SBS). Method Data were collected between January and February 2017 using the SBS. Results The sample was composed mostly of men from Rio de Janeiro state, with mean age of 60.4 years, illiterate, benefit recipients, with schizophrenia and other psychotic disorders and a long period of previous hospitalization with no contact with their families. Approximately 96% of them showed at least one social behavior problem, often related to poor self-care, little spontaneous communication (Does the person start a conversation?), slowness, laughing and talking to self, and other problems (any other behavior or attitude not previously specified that seem to be delaying the progress of the person). Conclusion This population presented high frequency of social disablement that may prevent their social reintegration, evidencing the need for implementing social rehabilitation programs.
DOI: 10.6084/m9.figshare.7101578
title: Rebound tonometry versus Goldmann tonometry in school children: feasibility and agreement of intraocular pressure measurements

description: ABSTRACT Purpose: High intraocular pressure (IOP) is an important risk factor for a variety of pediatric ophthalmic conditions. The purpose of this study is to evaluate the feasibility, length of examination, and corneal epithelial damage induced by rebound tonometry (RBT) versus Goldmann applanation tonometry (GAT) in school children. Methods: Healthy children (n=57) participated in a randomized, transversal study with IOP measurement by GAT followed by RBT (study arm 1) or RBT followed by GAT (study arm 2). The number of attempts to acquire a reliable IOP measurement and the length of the examination were quantified. Corneal epithelial damage induced by tonometry was evaluated. Bland-Altman analysis was performed to establish the level of agreement between the two techniques. Results: The IOP was measured in all children with at least one of the devices. In both study arms, more children failed to be examined with GAT than with RBT (26% vs. 4%, and 16% vs. 6%, p&lt;0.001, in study arm 1 and 2, respectively). The length of examination was shorter for RBT than for GAT (67.81 s ± 35.20 s vs. 126.70 s ± 56.60 s; p&lt;0.0001); IOP measurements with RBT in both study arms were higher than those with GAT (15.20 ± 2.74 mmHg vs. 13.25 ± 2.47 mmHg, p=0.0247 and 16.76 ± 3.99 mmHg vs. 13.92 ± 2.08 mmHg, p=0.003, respectively). No difference was observed between RBT and GAT regarding the corneal epithelial damage caused by tonometry. Conclusion: IOP measurement is feasible in a greater number of children with RBT, and the examination was faster than that for GAT. Compared with GAT, RBT tended to overestimate the IOP. None of the methods induced marked corneal epithelial defects.
DOI: 10.6084/m9.figshare.7101578.v1
title: Rebound tonometry versus Goldmann tonometry in school children: feasibility and agreement of intraocular pressure measurements

description: ABSTRACT Purpose: High intraocular pressure (IOP) is an important risk factor for a variety of pediatric ophthalmic conditions. The purpose of this study is to evaluate the feasibility, length of examination, and corneal epithelial damage induced by rebound tonometry (RBT) versus Goldmann applanation tonometry (GAT) in school children. Methods: Healthy children (n=57) participated in a randomized, transversal study with IOP measurement by GAT followed by RBT (study arm 1) or RBT followed by GAT (study arm 2). The number of attempts to acquire a reliable IOP measurement and the length of the examination were quantified. Corneal epithelial damage induced by tonometry was evaluated. Bland-Altman analysis was performed to establish the level of agreement between the two techniques. Results: The IOP was measured in all children with at least one of the devices. In both study arms, more children failed to be examined with GAT than with RBT (26% vs. 4%, and 16% vs. 6%, p&lt;0.001, in study arm 1 and 2, respectively). The length of examination was shorter for RBT than for GAT (67.81 s ± 35.20 s vs. 126.70 s ± 56.60 s; p&lt;0.0001); IOP measurements with RBT in both study arms were higher than those with GAT (15.20 ± 2.74 mmHg vs. 13.25 ± 2.47 mmHg, p=0.0247 and 16.76 ± 3.99 mmHg vs. 13.92 ± 2.08 mmHg, p=0.003, respectively). No difference was observed between RBT and GAT regarding the corneal epithelial damage caused by tonometry. Conclusion: IOP measurement is feasible in a greater number of children with RBT, and the examination was faster than that for GAT. Compared with GAT, RBT tended to overestimate the IOP. None of the methods induced marked corneal epithelial defects.
DOI: 10.6084/m9.figshare.7101581
title: Care flows of moderate and severe burned patients in regions and health care networks of Minas Gerais

description: Abstract Background Burns, a problem of high incidence in the general population, reach people of all ages and social levels. Severity variation involves care at all levels of care. In 2000, the Brazilian Ministry of Health determined the organization of state burn centers specialized in the assistance of high complexity burns. Objective The configuration of care networks influences the health-disease process of the populations, organizes the flow of patients in the search for care, especially in the public system (SUS), reinforcing the logic of regionalized and hierarchical networks of care. Method This article mapped the flow of patients with severe burns under SUS, in the state of Minas Gerais, from January 2013 to December 2015. Results Ten macro-regions of health were not self-sufficient in the hospitalizations of their patients. The macro-region Center, city of Belo Horizonte, stood out as an important assistance network to the burned patient in the state. The North Macro-region was the best example of a network according to the SUS regionalization guidelines. Conclusion The study identified gaps in the distribution of assistance and pointed to the need for investments to create reference centers with equitable distribution in the state of Minas Gerais.
DOI: 10.6084/m9.figshare.7101581.v1
title: Care flows of moderate and severe burned patients in regions and health care networks of Minas Gerais

description: Abstract Background Burns, a problem of high incidence in the general population, reach people of all ages and social levels. Severity variation involves care at all levels of care. In 2000, the Brazilian Ministry of Health determined the organization of state burn centers specialized in the assistance of high complexity burns. Objective The configuration of care networks influences the health-disease process of the populations, organizes the flow of patients in the search for care, especially in the public system (SUS), reinforcing the logic of regionalized and hierarchical networks of care. Method This article mapped the flow of patients with severe burns under SUS, in the state of Minas Gerais, from January 2013 to December 2015. Results Ten macro-regions of health were not self-sufficient in the hospitalizations of their patients. The macro-region Center, city of Belo Horizonte, stood out as an important assistance network to the burned patient in the state. The North Macro-region was the best example of a network according to the SUS regionalization guidelines. Conclusion The study identified gaps in the distribution of assistance and pointed to the need for investments to create reference centers with equitable distribution in the state of Minas Gerais.
DOI: 10.6084/m9.figshare.7101572
title: Detection of Toxoplasma gondii DNA in peripheral blood and aqueous humor of patients with Toxoplasmic active focal necrotizing retinochoroiditis using real-time PCR

description: ABSTRACT Purpose: To evaluate the ability of real-time quantitative PCR (qPCR) for detectingToxoplasma gondii DNA in the peripheral blood and aqueous humor of patients with toxoplasmic active focal necrotizing retinochoroiditis. Methods: Fifty-five patients with infectious uveitis seen from 2009 to 2013 at the Department of Ophthalmology and Visual Sciences of the Federal University of São Paulo were enrolled in this study. Forty-three patients had toxoplasmic active focal necrotizing retinochoroiditis, and the remaining 12 had non-toxoplasmic infectious uveitis and served as controls. qPCR analysis forT. gondii DNA was performed on the patients' peripheral blood and aqueous humor samples. Results: The qPCR was positive for T. gondii DNA in 37.21% (16/43) of the aqueous humor samples and 2.33% (1/43) of the peripheral blood samples; further, 16.27% (7/43) of the patients had positive results in both their blood and aqueous humor samples. Conclusion: qPCR was able to detect T. gondii DNA in patients with toxoplasmic active focal necrotizing retinochoroiditis in the blood as well as the aqueous humor and can help with the diagnosis of the disease.
DOI: 10.6084/m9.figshare.7101575
title: Quality-of-life perception in elderly women who practice and do not practice the Pilates’ method

description: Abstract Background The aging process causes a reduction of the physical function, allowing the individual to have a decrease in the perception of the quality of life. Therefore, regular physical activity can be a favorable factor for a better perception of quality of life. Objective The aim of this study was to compare the quality-of-life perception of elderly women practitioners and non-practitioners of the Pilates’ method. Method divided into three exercise type groups and two age groups: 60-64.9 and 70-74.9 years. The exercise type groups were as follows: Pilates’ method practitioners (n=60), gymnastics practitioners (n=63), and non-practitioners of regular physical activity (n=62). The WHOQOL-OLD and WHOQOL-BREF questionnaires were applied to evaluate the quality-of-life perception. Statistics: The Shapiro-Wilk test verified the data distribution and comparative analysis was conducted using the Kruskal-Wallis test with Mann-Whitney Post-Hoc and Bonferroni correction. All analyses were processed using the SPSS software at 5% significance level (p&lt;0.05). Results For 60-64.9-year-old group assessed by the WHOQOL-OLD questionnaire, the non-practitioners of regular physical activity showed better perception in the social participation domain than that of the gymnastic practitioners. For 70-74.9-year-old group assessed by the same instrument, the Pilates’ method practitioners showed the best perception in most of the quality-of-life domains. Conclusion Elderly women practitioners of the Pilates’ method obtained the highest scores in most of the quality-of-life domains for the 70-74.9-year-old group.
DOI: 10.6084/m9.figshare.7101572.v1
title: Detection of Toxoplasma gondii DNA in peripheral blood and aqueous humor of patients with Toxoplasmic active focal necrotizing retinochoroiditis using real-time PCR

description: ABSTRACT Purpose: To evaluate the ability of real-time quantitative PCR (qPCR) for detectingToxoplasma gondii DNA in the peripheral blood and aqueous humor of patients with toxoplasmic active focal necrotizing retinochoroiditis. Methods: Fifty-five patients with infectious uveitis seen from 2009 to 2013 at the Department of Ophthalmology and Visual Sciences of the Federal University of São Paulo were enrolled in this study. Forty-three patients had toxoplasmic active focal necrotizing retinochoroiditis, and the remaining 12 had non-toxoplasmic infectious uveitis and served as controls. qPCR analysis forT. gondii DNA was performed on the patients' peripheral blood and aqueous humor samples. Results: The qPCR was positive for T. gondii DNA in 37.21% (16/43) of the aqueous humor samples and 2.33% (1/43) of the peripheral blood samples; further, 16.27% (7/43) of the patients had positive results in both their blood and aqueous humor samples. Conclusion: qPCR was able to detect T. gondii DNA in patients with toxoplasmic active focal necrotizing retinochoroiditis in the blood as well as the aqueous humor and can help with the diagnosis of the disease.
DOI: 10.6084/m9.figshare.7101575.v1
title: Quality-of-life perception in elderly women who practice and do not practice the Pilates’ method

description: Abstract Background The aging process causes a reduction of the physical function, allowing the individual to have a decrease in the perception of the quality of life. Therefore, regular physical activity can be a favorable factor for a better perception of quality of life. Objective The aim of this study was to compare the quality-of-life perception of elderly women practitioners and non-practitioners of the Pilates’ method. Method divided into three exercise type groups and two age groups: 60-64.9 and 70-74.9 years. The exercise type groups were as follows: Pilates’ method practitioners (n=60), gymnastics practitioners (n=63), and non-practitioners of regular physical activity (n=62). The WHOQOL-OLD and WHOQOL-BREF questionnaires were applied to evaluate the quality-of-life perception. Statistics: The Shapiro-Wilk test verified the data distribution and comparative analysis was conducted using the Kruskal-Wallis test with Mann-Whitney Post-Hoc and Bonferroni correction. All analyses were processed using the SPSS software at 5% significance level (p&lt;0.05). Results For 60-64.9-year-old group assessed by the WHOQOL-OLD questionnaire, the non-practitioners of regular physical activity showed better perception in the social participation domain than that of the gymnastic practitioners. For 70-74.9-year-old group assessed by the same instrument, the Pilates’ method practitioners showed the best perception in most of the quality-of-life domains. Conclusion Elderly women practitioners of the Pilates’ method obtained the highest scores in most of the quality-of-life domains for the 70-74.9-year-old group.
DOI: 10.6084/m9.figshare.7101566
title: Comparison of central corneal thickness estimated by an ultrasonic pachymeter and non-contact specular microscopy

description: ABSTRACT Purpose: To compare central corneal thickness (CCT) measurements of healthy individuals obtained with ultrasonic pachymetry (UP) and non-contact specular microscopy (NCSM). Method: In total, 148 eyes of 74 subjects with no ocular or systemic diseases were included in the study. Central corneal thickness measurements of all patients performed with UP and NCCM were compared. Results: A total of 74 subjects (38 females) were included in this study. The mean age was 45.2 ± 18.4 (range 12-85) years. The mean central corneal thickness of all 148 eyes was 546.9 ± 40 μm with UP and 510.8 ± 42 μm with NCSM. The mean central corneal thickness measured with NCSM was 35 μm thinner than that measured with UP (p&lt;0.001). A high degree of agreement was found between the two methods (r=0.942, p&lt;0.001). Conclusions: Our results suggest that NCSM measures thinner corneas than UP and that the correction formula we identified should be applied when comparing between these two devices.
DOI: 10.6084/m9.figshare.7101569
title: Crashworthiness Performance of Stiffened Foam-filled Tapered Structures under Axial and Oblique Dynamic Loads

description: Abstract This paper aims to explore crashworthiness performance of new designed foam-filled tapered structures under axial and oblique impact load conditions. The structures consisted of inner and outer tapered tubes connected together by four stiffening plates. They also included square, hexagonal, octagonal, decagonal and circular cross-sectional shapes with different ratios of a/b (ratio of the inner tube side length to the outer tube one). The ratio of a/b was assumed to be 0, 0.25, 0.5, 0.75 and 1. Crashworthiness criteria of specific energy absorption (SEA), peak collapse force (Fmax) and crash force efficiency (CFE) were obtained for these structures using the experimentally validated model in LS-DYNA. Based on the numerical results, semi-foam filled structures (i.e. those with the ratio of a/b=0.5) demonstrated greater crashworthiness performance than foam filled single-cell ones. Furthermore, according to the TOPSIS calculations, cross sectional shape of decagonal was found to be an outstanding potential profile for the automobile structural components.
DOI: 10.6084/m9.figshare.7101569.v1
title: Crashworthiness Performance of Stiffened Foam-filled Tapered Structures under Axial and Oblique Dynamic Loads

description: Abstract This paper aims to explore crashworthiness performance of new designed foam-filled tapered structures under axial and oblique impact load conditions. The structures consisted of inner and outer tapered tubes connected together by four stiffening plates. They also included square, hexagonal, octagonal, decagonal and circular cross-sectional shapes with different ratios of a/b (ratio of the inner tube side length to the outer tube one). The ratio of a/b was assumed to be 0, 0.25, 0.5, 0.75 and 1. Crashworthiness criteria of specific energy absorption (SEA), peak collapse force (Fmax) and crash force efficiency (CFE) were obtained for these structures using the experimentally validated model in LS-DYNA. Based on the numerical results, semi-foam filled structures (i.e. those with the ratio of a/b=0.5) demonstrated greater crashworthiness performance than foam filled single-cell ones. Furthermore, according to the TOPSIS calculations, cross sectional shape of decagonal was found to be an outstanding potential profile for the automobile structural components.