cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20064797.v1
title: Additional file 8 of mirTarRnaSeq: An R/Bioconductor Statistical Package for miRNA-mRNA Target Identification and Interaction Analysis

description: Additional file 8.
DOI: 10.6084/m9.figshare.20064800
title: Additional file 9 of mirTarRnaSeq: An R/Bioconductor Statistical Package for miRNA-mRNA Target Identification and Interaction Analysis

description: Additional file 9.
DOI: 10.6084/m9.figshare.20064827.v1
title: Additional file 1 of From a long-distance threat to the invasion front: a review of the invasive Aedes mosquito species in Belgium between 2007 and 2020

description: Additional file 1: Table S1. Overview of the trapping methods used to monitor invasive mosquito species (IMS) in Belgium during the different years (and projects) and in different risk scenarios, indicating the number of traps or larval sampling visits per site and the frequency of trapping or larval sampling. Table S2. Aedes albopictus detections in Belgium between 2007 and 2020 at the ten points of entry (PoEs) per year including the sampling perimeter, collection and detection methods, collection (light grey) and detection (dark grey) period, control measures (X), number of individuals (total, females, males, larvae and eggs) and project. Table S3. Aedes japonicus detections in Belgium between 2007 and 2020 at the four points of entry (PoEs) per year including the sampling perimeter, collection and detection methods, collection (light grey) and detection (dark grey) period, the control measures (X), number of individuals (total, females, males, larvae and eggs) and project. Table S4. Aedes koreicus detections in Belgium between 2007 and 2020 at the two points of entry (PoEs) per year including the sampling perimeter, collection and detection methods, collection (light grey) and detection (dark grey) period, control measures (X), number of individuals (total, females, males, larvae and eggs) and project.
DOI: 10.6084/m9.figshare.20064827
title: Additional file 1 of From a long-distance threat to the invasion front: a review of the invasive Aedes mosquito species in Belgium between 2007 and 2020

description: Additional file 1: Table S1. Overview of the trapping methods used to monitor invasive mosquito species (IMS) in Belgium during the different years (and projects) and in different risk scenarios, indicating the number of traps or larval sampling visits per site and the frequency of trapping or larval sampling. Table S2. Aedes albopictus detections in Belgium between 2007 and 2020 at the ten points of entry (PoEs) per year including the sampling perimeter, collection and detection methods, collection (light grey) and detection (dark grey) period, control measures (X), number of individuals (total, females, males, larvae and eggs) and project. Table S3. Aedes japonicus detections in Belgium between 2007 and 2020 at the four points of entry (PoEs) per year including the sampling perimeter, collection and detection methods, collection (light grey) and detection (dark grey) period, the control measures (X), number of individuals (total, females, males, larvae and eggs) and project. Table S4. Aedes koreicus detections in Belgium between 2007 and 2020 at the two points of entry (PoEs) per year including the sampling perimeter, collection and detection methods, collection (light grey) and detection (dark grey) period, control measures (X), number of individuals (total, females, males, larvae and eggs) and project.
DOI: 10.6084/m9.figshare.20064883.v1
title: Additional file 1 of Influence of emotional intelligence on the clinical ability of nursing interns: a structural equation model

description: Additional file 1.
DOI: 10.6084/m9.figshare.20064883
title: Additional file 1 of Influence of emotional intelligence on the clinical ability of nursing interns: a structural equation model

description: Additional file 1.
DOI: 10.6084/m9.figshare.20064928
title: Additional file 1 of Cultural adaptation of the mental health first aid guidelines for assisting a person at risk of suicide in Brazil: a Delphi expert consensus study

description: Additional file 1.
DOI: 10.6084/m9.figshare.20064928.v1
title: Additional file 1 of Cultural adaptation of the mental health first aid guidelines for assisting a person at risk of suicide in Brazil: a Delphi expert consensus study

description: Additional file 1.
DOI: 10.6084/m9.figshare.19102319
title: Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer

description: Endometrial cancer (EC) is a common and deadly cancer in women and novel therapeutic approaches are urgently needed. Polyamines (putrescine, spermidine, spermine) are critical for mammalian cell proliferation and MYC coordinately regulates polyamine metabolism through ornithine decarboxylase (ODC). ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug α-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumour growth arrest. Spermidine is required for the hypusine-dependent activation of eukaryotic translation initiation factors 5A1 (eIF5A1) and 5A2 (eIF5A2) and connects the MYC/ODC-induced deregulation of spermidine to eIF5A1/2 protein translation, which is increased during cancer cell proliferation. We show that eIF5A1 is significantly upregulated in EC cells compared to control cells (<i>p</i>=.000038) and that combined pharmacological targeting of ODC and eIF5A hypusination with cytostatic drugs DFMO and N1-guanyl-1,7-diaminoheptane (GC7), respectively, reduces eIF5A1 activation and synergistically induces apoptosis in EC cells. <i>In vivo</i>, DFMO/GC7 suppressed xenografted EC tumour growth in mice more potently than each drug alone compared to control (<i>p</i>=.002) and decreased putrescine (<i>p</i>=.045) and spermidine levels in tumour tissues. Our data suggest DFMO and GC7 combination therapy may be useful in the treatment or prevention of EC.
DOI: 10.6084/m9.figshare.19102319.v2
title: Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer

description: Endometrial cancer (EC) is a common and deadly cancer in women and novel therapeutic approaches are urgently needed. Polyamines (putrescine, spermidine, spermine) are critical for mammalian cell proliferation and MYC coordinately regulates polyamine metabolism through ornithine decarboxylase (ODC). ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug α-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumour growth arrest. Spermidine is required for the hypusine-dependent activation of eukaryotic translation initiation factors 5A1 (eIF5A1) and 5A2 (eIF5A2) and connects the MYC/ODC-induced deregulation of spermidine to eIF5A1/2 protein translation, which is increased during cancer cell proliferation. We show that eIF5A1 is significantly upregulated in EC cells compared to control cells (<i>p</i>=.000038) and that combined pharmacological targeting of ODC and eIF5A hypusination with cytostatic drugs DFMO and N1-guanyl-1,7-diaminoheptane (GC7), respectively, reduces eIF5A1 activation and synergistically induces apoptosis in EC cells. <i>In vivo</i>, DFMO/GC7 suppressed xenografted EC tumour growth in mice more potently than each drug alone compared to control (<i>p</i>=.002) and decreased putrescine (<i>p</i>=.045) and spermidine levels in tumour tissues. Our data suggest DFMO and GC7 combination therapy may be useful in the treatment or prevention of EC.
DOI: 10.6084/m9.figshare.20064098
title: DATA for Artificial Intelligence automates the characterization of reversibly actuating planar-flow-casted NiTi shape memory alloy foil

description: Nickel-Titanium (NiTi) shape memory alloys (SMAs) are smart materials able to recover their original shape under thermal stimulus. Near-net-shape NiTi SMA foils of 2 meters in length and width of 30 mm have been successfully produced by a planar flow casting facility at CSIRO, opening possibilities of wider applications of SMA foils. The study also focuses on establishing a fully automated experimental system for the characterisation of their reversible actuation, significantly improving SMA foils adaptation into real applications. Artificial Intelligence involving Computer Vision and Machine Learning based methods were successfully employed in the development of the automation SMA characterization process. The study finds that an Extreme Gradient Boosting (XGBoost) Regression model based predictive system experimented with over 175,000 video samples could achieve 99% overall prediction accuracy. Generalisation capability of the proposed system makes a significant contribution towards the efficient optimisation of the material design to produce high quality 30 mm SMA foils. This repository is related to this publication. <br> SI-1 Video: Demonstration video file for a 4BENDS shaped SMA foil while analysed through the newly proposed predictive AI system. SI-2 Video: Demonstration video file for a HALF CIRCLE shaped SMA foil while analysed through the newly proposed predictive AI system. SI-3 Video: Demonstration video file for an OMEGA shaped SMA foil while analysed through the newly proposed predictive AI system. SI-4 Video: Demonstration video file for a V shaped SMA foil while analysed through the newly proposed predictive AI system. 4BENDS_all_syncd_targets.txt: training targets for the 4 BENDS shaped SMA foils. 4BENDS_inputs_.txt: training inputs for the 4 BENDS shaped SMA foils. HALFCIRCLE_all_syncd_targets.txt: training targets for the HALF CIRCLE shaped SMA foils. HALFCIRCLE _inputs_.txt: training inputs for the HALF CIRCLE shaped SMA foils. OMEGA_all_syncd_targets.txt: training targets for the OMEGA shaped SMA foils. OMEGA_inputs_.txt: training inputs for the OMEGA shaped SMA foils. V_all_syncd_targets.txt: training targets for the V shaped SMA foils. V_inputs_.txt: training inputs for the V shaped SMA foils.
DOI: 10.34808/ytw9-yd49
title: Synovial sarcoma, biphasic - Female, 41 - Tissue image [6130730026841961]

description: This is the histopathological image of CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 41Clinical description: Tumor of subcutaneous tissue of left knee.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: SYNOVIAL-LIKE NEOPLASMSDiagnosis: Synovial sarcoma, biphasicResult of the histopathological examination: Synovial sarcoma, biphasic: TLE1+, EMA+, CD56+, CD99+. Presence of SS18 rearrangement.Sample:Material: FFPECollecting method: Excision of lesionsTopography: CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUESOrgan: CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUESTissue: Connective, subcutaneous and other soft tissues of kneeType of staining: positive/IHCStaining: Not applicableAntibody: EMATechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/bc20-7936
title: Neurofibroma, NOS - Female, 57 - Tissue image [6120730031816371]

description: This is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 57Clinical description: Brown elevated lesion of skin of chest with dimensions 0,7 x 0,5 x 0,4 cm.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: NERVE SHEATH TUMORSDiagnosis: Neurofibroma, NOSResult of the histopathological examination: Neurofibroma: S100+, SOX10+, CD34-, CD31-, CKAE1/AE3-, MelanA-, Ki-67 15%.Sample:Material: FFPECollecting method: Excision of lesionsTopography: SKINOrgan: SKINTissue: Skin of chestType of staining: positive/IHCStaining: Not applicableAntibody: s100Technology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/xzqz-p612
title: Twin pregnancy - Female, 33 - Tissue image [6110730021445601]

description: This is the histopathological image of PLACENTA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 33Clinical description: Twin pregnancy, dichorionic, diamniotic.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XV - Pregnancy, childbirth and the puerperiumDiagnosis: Twin pregnancyResult of the histopathological examination: Fetal membranes with usual structure.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: PLACENTATissue: Fetal membranesType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/cga4-cy84
title: Clear cell adenocarcinoma, NOS - Female, 87 - Tissue image [6120730031802761]

description: This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 87Clinical description: Polypoid tumor of uterine cavity with dimensions 3,5 x 1,5 x 1,5 cm.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: ADENOMAS AND ADENOCARCINOMASDiagnosis: Clear cell adenocarcinoma, NOSResult of the histopathological examination: Endometrial clear cell adenocarcinoma G3.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: CORPUS UTERITissue: EndometriumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/av6j-fz09
title: SMALL INTESTINE, Jejunum - Female, 45 - Tissue image [6140730016115531]

description: This is the histopathological image of SMALL INTESTINE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 45Clinical description: Tumor of the small intestine.Gender: FemaleDiagnosis:Classification: HealthyClassification code: Diagnosis: Result of the histopathological examination: Neuroendocrine tumor NET G1 of the small intestine. IHC: synaptophysin +, chromogranin +, Ki67 1%.
The tumor infiltrates the muscular wall, penetrates the fat tissue, and superficially infiltrates the serosa.Sample:Material: FFPECollecting method: Surgical specimenTopography: DIGESTIVE ORGANSOrgan: SMALL INTESTINETissue: JejunumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/z784-r451
title: Leiomyosarcoma, NOS - Female, 84 - Tissue image [6120730031814351]

description: This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 84Clinical description: Tumor of pancreas.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: MYOMATOUS NEOPLASMSDiagnosis: Leiomyosarcoma, NOSResult of the histopathological examination: Leiomyosarcoma G3: SMA+, DES+, h-caldesmone+, CD34-, MDM2-, Ki-67 50%.Sample:Material: FFPECollecting method: Surgical specimenTopography: RETROPERITONEUM AND PERITONEUMOrgan: RETROPERITONEUM AND PERITONEUMTissue: RetroperitoneumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/44my-7m97
title: Plasma cell myeloma - Female, 51 - Tissue image [6130730026846101]

description: This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 51Clinical description: No clinical data.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: PLASMA CELL TUMORSDiagnosis: Plasma cell myelomaResult of the histopathological examination: Myeloma: hypercellular bone marrow, diffuse and interstitial infiltration of atypical plasma cells (CD138+, kappa+, lambda-, Cd20-). Focally reticulin fibrosis (1+).Sample:Material: FFPECollecting method: Bone marrow biopsyTopography: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMSOrgan: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMSTissue: Bone marrowType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/veh6-nk15
title: Neurofibroma, NOS - Male, 63 - Tissue image [6120730031814531]

description: This is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 63Clinical description: Patient with neurofibromatosis. Lesion of skin of trunk.Gender: MaleDiagnosis:Classification: ICD-O_3.2Classification code: NERVE SHEATH TUMORSDiagnosis: Neurofibroma, NOSResult of the histopathological examination: Neurofibroma with dermis and fatty tissue infiltration: S100+, SOX-10+, SMA-, DES-, CKAE1/AE3-, EMA-, MDM2-, Ki-67 1%.Sample:Material: FFPECollecting method: Excision of lesionsTopography: SKINOrgan: SKINTissue: Skin of trunkType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/kr6h-wx07
title: Atypical polypoid adenomyoma - Female, 38 - Tissue image [61207300318171]

description: This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 38Clinical description: Suspicion of atypical polypoid adenomyoma.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: COMPLEX MIXED AND STROMAL NEOPLASMSDiagnosis: Atypical polypoid adenomyomaResult of the histopathological examination: Atypical polypoid adenomyoma. Epithelial component: ER+, CD10 focally+, p63 focally+, PTEN-, CEA-, SMA-, Ki-67 50%. Stroma: SMA+, ER+, PTEN+, CD10-, p63-, CEA-, Ki-67 10%.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: CORPUS UTERITissue: Corpus uteriType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/a8gm-1w77
title: Leiomyosarcoma, NOS - Female, 84 - Tissue image [6120730031813611]

description: This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 84Clinical description: Tumor of pancreas.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: MYOMATOUS NEOPLASMSDiagnosis: Leiomyosarcoma, NOSResult of the histopathological examination: Leiomyosarcoma G3: SMA+, DES+, h-caldesmone+, CD34-, MDM2-, Ki-67 50%.Sample:Material: FFPECollecting method: Surgical specimenTopography: RETROPERITONEUM AND PERITONEUMOrgan: RETROPERITONEUM AND PERITONEUMTissue: RetroperitoneumType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/sqqv-6p37
title: Endometriosis - Female, 37 - Tissue image [613073002686811]

description: This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 37Clinical description: Endometriosis of corpus uterus, ovary and abdominal cavity. Tumor of urinary bladder and colon.Gender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XIV - Diseases of the genitourinary systemDiagnosis: EndometriosisResult of the histopathological examination: Endometriosis.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: OVARYTissue: OvaryType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk
DOI: 10.34808/m1rs-fx90
title: Ancient schwannoma - Male, 66 - Tissue image [6120730031827821]

description: This is the histopathological image of CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 66Clinical description: Subcutaneous tumor of lower limb with dimensions 3 x 1,5 x 1,5 cm.Gender: MaleDiagnosis:Classification: ICD-O_3.2Classification code: NERVE SHEATH TUMORSDiagnosis: Ancient schwannomaResult of the histopathological examination: Ancient schwannoma: SOX10+, S100+, CD34-, CKAE1/AE3-, SMA-, MelanA-, Ki-67 3%.Sample:Material: FFPECollecting method: Excision of lesionsTopography: CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUESOrgan: CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUESTissue: Connective, subcutaneous and other soft tissues of lower limb and hipType of staining: positive/IHCStaining: Not applicableAntibody: SMATechnology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk