cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24631254
title: Supplementary Material for: Exercise Regulates Myokines on Aging-related Diseases through Muscle-brain Crosstalk

description: Background: The related functions of skeletal muscle and brain decrease significantly with age, and muscle-brain-related diseases are primarily associated with each other. Exercise can promote the secretion of myokines in skeletal muscle, showing a beneficial effect on the function of both, reflecting muscle-brain crosstalk. However, the key mechanism of action of exercise-regulated myokines in muscle-brain diseases remains unclear.
Methods: Web of Science, PubMed, EBSCO, OVID, and China National Knowledge Infrastructure were searched from July 2022 to February 2023 using “myokine,” “myokines,” “exercise,” “training,” “physical activity,” “aging,” “brain” and “crosstalk” as keywords.
Results: Twenty-four experimental studies were selected from 2,941 studies involving seven common myokines. The exercises studied included aerobic exercise, resistance exercise, combined aerobic and resistance exercise, high-intensity interval training (HIIT), and high-intensity circuit training (HICT). Eighteen of the studies mentioned brain-derived neurotrophic factor (BDNF), four mentioned insulin-like growth factor 1 (IGF-1), three mentioned cathepsin B (CATB), and four mentioned irisin. There were four with vascular endothelial growth factor (VEGF), five with interleukin 6 (IL-6), and three with fibroblast growth factor 21 (FGF-21). There are multiple studies involving multiple myokines at the same time.
Conclusions: Type, duration, intensity, and frequency of exercise may affect the expression of myokines in muscle-brain crosstalk. Both low- to moderate-intensity aerobic exercise three times a week for 12 weeks or more and resistance exercise two or three times a week with low or moderate-intensity for 12 weeks have a strong effect on the expression of myokines. However, there are few studies on the effects of combined aerobic and resistance exercise, HIIT, and HICT on myokines, and more empirical studies are required in the future.
DOI: 10.6084/m9.figshare.24631071
title: Supplementary Material for: European Nephrologists' Attitudes Towards the Application of Artificial Intelligence in Clinical Practice: A Comprehensive Survey

description: Introduction: The rapid advancement of artificial intelligence and big data analytics, including descriptive, diagnostic, predictive, and prescriptive analytics, has the potential to revolutionize many areas of medicine, including nephrology and dialysis. Artificial intelligence and big data analytics can be used to analyse large amounts of patient medical records, including laboratory results and imaging studies, to improve the accuracy of diagnosis, enhance early detection, identify patterns and trends, and personalize treatment plans for patients with kidney disease. Additionally, artificial intelligence and big data analytics can be used to identify patients’ treatment who are not receiving adequate care, highlighting care inefficiencies in the dialysis provider, optimizing patient outcomes, and reducing healthcare costs, and consequently creating values for all the involved stakeholders. 
Objectives: We present the results of a comprehensive survey aimed at exploring the attitudes of European physicians from eight countries working within a major hemodialysis network (Fresenius Medical Care) towards the application of Artificial intelligence in clinical practice. 
Methods: An electronic survey on the implementation of artificial intelligence in hemodialysis clinics was distributed to 1,067 physicians. Of the 1,067 individuals invited to participate in the study, 404 (37.9%) professionals agreed to participate in the survey. Results: The survey showed that a substantial proportion of respondents believe that artificial intelligence has the potential to support physicians in reducing medical malpractice or mistakes. 
Conclusion: While artificial intelligence's potential benefits are recognized in reducing medical errors and improving decision-making, concerns about treatment plan consistency, personalization, privacy, and the human aspects of patient care persist. Addressing these concerns will be crucial for successfully integrating artificial intelligence solutions in nephrology practice.
DOI: 10.6084/m9.figshare.24755244
title: Airway contraction and cytokine release in isolated rat lungs induced by wear particles from the road and tire interface and road vehicle brakes

description: The dominant road traffic particle sources are wear particles from the road and tire interface, and from vehicle brake pads. The aim of this work was to investigate the effect of road and brake wear particles on pulmonary function and biomarkers in isolated perfused rat lungs. Particles were sampled from the studded tire wear of three road pavements containing different rock materials in a road simulator; and from the wear of two brake pad materials using a pin-on-disk machine. Isolated rat lungs inhaled the coarse and fine fractions of the sampled particles resulting in an estimated total particle lung dose of 50 μg. The tidal volume (TV) was measured during the particle exposure and the following 50 min. Perfusate and BALF were analyzed for the cytokines TNF, CXCL1 and CCL3. The TV of lungs exposed to rock materials was significantly reduced after 25 min of exposure compared to the controls, for quartzite already after 4 min. The particles of the heavy-duty brake pads had no effect on the TV. Brake particles resulted in a significant elevation of CXCL1 in the perfusate. Brake particles showed significant elevations of all three measured cytokines, and quartzite showed a significant elevation of TNF in BALF. The study shows that the toxic effect on lungs exposed to airborne particles can be investigated using measurements of tidal volume. Furthermore, the study shows that the choice of rock material in road pavements has the potential to affect the toxicity of road wear PM10.
DOI: 10.6084/m9.figshare.24755244.v1
title: Airway contraction and cytokine release in isolated rat lungs induced by wear particles from the road and tire interface and road vehicle brakes

description: The dominant road traffic particle sources are wear particles from the road and tire interface, and from vehicle brake pads. The aim of this work was to investigate the effect of road and brake wear particles on pulmonary function and biomarkers in isolated perfused rat lungs. Particles were sampled from the studded tire wear of three road pavements containing different rock materials in a road simulator; and from the wear of two brake pad materials using a pin-on-disk machine. Isolated rat lungs inhaled the coarse and fine fractions of the sampled particles resulting in an estimated total particle lung dose of 50 μg. The tidal volume (TV) was measured during the particle exposure and the following 50 min. Perfusate and BALF were analyzed for the cytokines TNF, CXCL1 and CCL3. The TV of lungs exposed to rock materials was significantly reduced after 25 min of exposure compared to the controls, for quartzite already after 4 min. The particles of the heavy-duty brake pads had no effect on the TV. Brake particles resulted in a significant elevation of CXCL1 in the perfusate. Brake particles showed significant elevations of all three measured cytokines, and quartzite showed a significant elevation of TNF in BALF. The study shows that the toxic effect on lungs exposed to airborne particles can be investigated using measurements of tidal volume. Furthermore, the study shows that the choice of rock material in road pavements has the potential to affect the toxicity of road wear PM10.
DOI: 10.6084/m9.figshare.24755479.v1
title: Vaping product exposure system (VaPES): a novel <i>in vitro</i> aerosol deposition system

description: Due to recent increases in the use of vaping devices, there is a high demand for research addressing the respiratory health effects of vaping products. Given the constantly changing nature of the vaping market with new devices, flavors, metals, and other chemicals rapidly emerging, there is a need for inexpensive and highly adaptable vaping device exposure systems. Here, we describe the design and validation of a novel <i>in vitro</i> aerosol exposure system for toxicity testing of vaping devices. We developed an inexpensive, open-source <i>in vitro</i> vaping device exposure system that produces even deposition, can be adapted for different vaping devices, and allows for experiments to be performed under physiological conditions. The system was then validated with deposition testing and a representative exposure with human bronchial epithelial cells (hBECs). The Vaping Product Exposure System (VaPES) produced sufficient and uniform deposition for dose-response studies and was precise enough to observe biological responses to vaping exposures. VaPES was adapted to work with both pod and cartridge-based vaping devices. We have designed and validated a novel vaping device exposure system that will eliminate the need to use high-cost commercial exposure systems, lowering the barrier to entry of physiologically relevant vaping studies.
DOI: 10.6084/m9.figshare.24799537
title: Supplementary Tables from The rediscovery of the putative ant social parasite <i>Manica parasitica</i> syn. nov. (Hymenoptera: Formicidae) reveals an unexpected endoparasite syndrome

description: Additional tables for Prebus MM, Georgiev BB, van de Kamp T, Hamann E, Baker I, Rabeling C. 2023. "The rediscovery of the putative ant social parasite Manica parasitica syn. nov. (Hymenoptera: Formicidae) reveals an unexpected endoparasite syndrome".
DOI: 10.6084/m9.figshare.24755479
title: Vaping product exposure system (VaPES): a novel <i>in vitro</i> aerosol deposition system

description: <b>Objective</b> Due to recent increases in the use of vaping devices, there is a high demand for research addressing the respiratory health effects of vaping products. Given the constantly changing nature of the vaping market with new devices, flavors, metals, and other chemicals rapidly emerging, there is a need for inexpensive and highly adaptable vaping device exposure systems. Here, we describe the design and validation of a novel <i>in vitro</i> aerosol exposure system for toxicity testing of vaping devices. <b>Materials and methods</b> We developed an inexpensive, open-source <i>in vitro</i> vaping device exposure system that produces even deposition, can be adapted for different vaping devices, and allows for experiments to be performed under physiological conditions. The system was then validated with deposition testing and a representative exposure with human bronchial epithelial cells (hBECs). <b>Results</b> The Vaping Product Exposure System (VaPES) produced sufficient and uniform deposition for dose-response studies and was precise enough to observe biological responses to vaping exposures. VaPES was adapted to work with both pod and cartridge-based vaping devices. <b>Conclusion</b> We have designed and validated a novel vaping device exposure system that will eliminate the need to use high-cost commercial exposure systems, lowering the barrier to entry of physiologically relevant vaping studies.
DOI: 10.17028/rd.lboro.24799437
title: Supplementary information files for Circular economy strategies for life cycle management of returnable transport items

description: Global trading activities rely heavily on several billions of transport packaging and returnable transport items, including pallets, containers, and crates, facilitating efficient product handling, transportation, and storage processes. Despite their benefits, their increased adoption across global logistics activities contribute to both environmental inefficiencies and increased packaging waste globally, creating the need for embedding circular economy principles into their lifecycle management processes. This paper, therefore, presents a systems thinking-driven integrative literature review to identify circular economy strategies for lifecycle management of returnable transport items. A circular economy lifecycle strategy mapping tool is initially developed for strategy mapping across the different intersections between the circular economy taxonomy of <i>regenerate, narrow, slow,</i> and <i>close</i>, and the <i>beginning, middle</i>, and <i>end of life</i> stages of returnable transport items. Following the structure of the tool, a strategic framework is proposed, consisting of distinct circular economy strategies throughout these different intersections, alongside a detailed analysis of the benefits, connections and trade-offs, and their impact on the system's environmental performance. The proposed framework offers guidance to returnable transport item poolers and logistics service providers towards embedding circular economy principles in their business models and improving the environmental sustainability of their fleet.
DOI: 10.6084/m9.figshare.21806103
title: Antimicrobial activity and phenolic composition of varieties of <i>Hibiscus sabdariffa</i> L. with red and white calyces

description: The antibacterial activities (ABAC) of white calyces varieties (WCV) of <i>Hibiscus sabdariffa</i> L has not been explored in depth. The aims of the study were to determine the ABAC of WCV and the relationship of phenolic composition with ABAC. Four experimental WCV (W1, W2, W3, and W4), and one with red calyces (RCV) were used. The ABAC of ethanol extracts were tested against Gram (+) and Gram (-) bacteria. WCV showed higher ABAC than RCV, and it was associated to flavonoid content which was 60% higher in WCV with respect to RCV. The free phenolic content of W1, W2, and W4 varieties was 50% higher than that observed in RCV and W3 varieties. The standardized abundance of N-feruloyltiramine and quercetin in the extracts of WCV was related with their highest ABAC. WCV are a promising source of phenolic compounds with high ABAC.
DOI: 10.6084/m9.figshare.21806103.v1
title: Antimicrobial activity and phenolic composition of varieties of <i>Hibiscus sabdariffa</i> L. with red and white calyces

description: The antibacterial activities (ABAC) of white calyces varieties (WCV) of <i>Hibiscus sabdariffa</i> L has not been explored in depth. The aims of the study were to determine the ABAC of WCV and the relationship of phenolic composition with ABAC. Four experimental WCV (W1, W2, W3, and W4), and one with red calyces (RCV) were used. The ABAC of ethanol extracts were tested against Gram (+) and Gram (-) bacteria. WCV showed higher ABAC than RCV, and it was associated to flavonoid content which was 60% higher in WCV with respect to RCV. The free phenolic content of W1, W2, and W4 varieties was 50% higher than that observed in RCV and W3 varieties. The standardized abundance of N-feruloyltiramine and quercetin in the extracts of WCV was related with their highest ABAC. WCV are a promising source of phenolic compounds with high ABAC.
DOI: 10.6084/m9.figshare.23608817.v1
title: A hybrid recommendation algorithm for green food based on review text and review time

description: Green food is well-known for its health benefits, environmental-friendliness, and safety. Current recommender systems used by e-commerce websites usually recommend products based on products' popularity or customers' ratings. However, users' reviews could be more representative of consumers' preferences. In addition, users' review time is not utilized. To reduce the recommendation bias, this study proposes a hybrid recommendation algorithm based on green food reviews and review time. The proposed algorithm combines a content-based recommendation algorithm with a user-based collaborative filtering approach, where affective values of reviews replace ratings and a time impact factor is considered. With the two classical evaluation indices of F1 and Mean Absolute Error (MAE), the experiments show that considering both reviews’ sentiments and dynamic changes of individuals’ preferences could improve recommendation effectiveness over three other algorithms, which provides a new reference direction for improving existing recommender systems on green food.
DOI: 10.6084/m9.figshare.22349040
title: The microbial composition and functional roles of different kombucha products in Singapore

description: Kombucha is a fermented tea known for its health-enhancing properties owing to the bioactive compounds generated by acetic acid bacteria (AAB) and lactic acid bacteria (LAB). We compared the distribution of AAB and LAB across nine kombucha products in Singapore (Product A to I) using shotgun metagenomics. High prevalence of Komagataeibacter species including Komagataeibacter saccharivorans (82.93% in B), Komagataeibacter xylinus (93.38% in D), and Komagataeibacter rhaeticus (92.20% and 30.62% in G and I) was detected in AAB-dominant kombucha. LAB-dominant kombucha was represented mainly by Bacillus coagulans (~99% in E and F) and Lactobacillus nagelii (~60% in H). Despite differences in bacterial composition, all kombucha harbour pathways involved in the biosynthesis of short-chain fatty acids (SCFAs), amino acids and vitamin B12. Interestingly, “fatty acid and beta-oxidation II (peroxisome)” and “fatty acid and beta-oxidation I” were only present in LAB-dominant kombucha. Further study is required to elucidate the significance of the discrepancies.
DOI: 10.25318/9810014501-fra
title: Conditions de logement des familles de militaires canadiens : Canada, provinces et territoires, régions métropolitaines de recensement et agglomérations de recensement y compris les parties

description: Données sur l'état de service militaire selon les indicateurs de logement, le type de ménage de la personne, le type de logement et le mode d'occupation incluant la présence de paiements hypothécaires et le logement subventionné pour la population âgée de 17 ans et plus dans les ménages propriétaires et locataires dont le revenu total du ménage est supérieur à zéro, dans les logements privés non agricoles et hors réserve au Canada, dans les provinces ou territoires, les régions métropolitaines de recensement, les agglomérations de recensement et les parties.
DOI: 10.6084/m9.figshare.23608817
title: A hybrid recommendation algorithm for green food based on review text and review time

description: Green food is well-known for its health benefits, environmental-friendliness, and safety. Current recommender systems used by e-commerce websites usually recommend products based on products' popularity or customers' ratings. However, users' reviews could be more representative of consumers' preferences. In addition, users' review time is not utilized. To reduce the recommendation bias, this study proposes a hybrid recommendation algorithm based on green food reviews and review time. The proposed algorithm combines a content-based recommendation algorithm with a user-based collaborative filtering approach, where affective values of reviews replace ratings and a time impact factor is considered. With the two classical evaluation indices of F1 and Mean Absolute Error (MAE), the experiments show that considering both reviews’ sentiments and dynamic changes of individuals’ preferences could improve recommendation effectiveness over three other algorithms, which provides a new reference direction for improving existing recommender systems on green food.
DOI: 10.6084/m9.figshare.24785829
title: Supplementary Material for: Preterm formula, fortified or unfortified human milk for very preterm infants, the PREMFOOD study, a parallel randomised feasibility trial

description: Objective: Uncertainty exists regarding optimal supplemental diet for very preterm infants if mother’s own milk (MM) is insufficient. We evaluated feasibility for a randomised controlled trial powered to detect important differences in health outcomes.
Methods: In this open, parallel, feasibility trial, we randomised infants 25+0-31+6 weeks gestation by opt-out consent, to one of three supplements to MM: unfortified human milk (UHM) (unfortified MM +/- unfortified pasteurised human donor milk (DM); fortified human milk (FHM) (fortified MM +/- fortified DM), and unfortified MM +/- preterm formula (PTF) from birth to 35+0 weeks post menstrual age. Feasibility outcomes included opt-outs, adherence rates, and slow growth safety criteria. We also obtained anthropometry, and magnetic resonance imaging body composition data at term and term plus 6 weeks (opt-in consent), as potential biomarkers for metabolic risk.
Results: 35 infants were randomised to UHM, 34 to FHM, and 34 to PTF groups, of which 21, 19, and 24 infants completed imaging at term. Opt-out consent was above target at 62%, while 6% of parents withdrew from feeding intervention. Two infants met predefined slow weight gain thresholds. There were no significant between-group differences in total adipose tissue volume at term (mean (sd): UHM: 0.870L (0.35L); FHM: 0.889L (0.31L); PTF: 0.809L (0.25L), p=0.66), nor in any other body composition measure or anthropometry at either timepoint.
Conclusions: Randomisation to UHM, FHM, and PTF feeding interventions by opt-out consent was acceptable to parents and clinical teams, associated with safe growth profiles, and body composition which did not indicate utility for biomarkers of metabolic risk.
DOI: 10.6084/m9.figshare.22349040.v1
title: The microbial composition and functional roles of different kombucha products in Singapore

description: Kombucha is a fermented tea known for its health-enhancing properties owing to the bioactive compounds generated by acetic acid bacteria (AAB) and lactic acid bacteria (LAB). We compared the distribution of AAB and LAB across nine kombucha products in Singapore (Product A to I) using shotgun metagenomics. High prevalence of Komagataeibacter species including Komagataeibacter saccharivorans (82.93% in B), Komagataeibacter xylinus (93.38% in D), and Komagataeibacter rhaeticus (92.20% and 30.62% in G and I) was detected in AAB-dominant kombucha. LAB-dominant kombucha was represented mainly by Bacillus coagulans (~99% in E and F) and Lactobacillus nagelii (~60% in H). Despite differences in bacterial composition, all kombucha harbour pathways involved in the biosynthesis of short-chain fatty acids (SCFAs), amino acids and vitamin B12. Interestingly, “fatty acid and beta-oxidation II (peroxisome)” and “fatty acid and beta-oxidation I” were only present in LAB-dominant kombucha. Further study is required to elucidate the significance of the discrepancies.