cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/nnm.24611913.v1
title: An update review of smart nanotherapeutics and liver cancer: opportunities and challenges - supplementary tables

description: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, typically diagnosed in advanced stages. Chemotherapy is necessary for treating advanced liver cancer; however, several challenges affect its effectiveness. These challenges include low specificity, high dosage requirements, high systemic toxicity and severe side effects, which significantly limit the efficacy of chemotherapy. These limitations can hinder the treatment of HCC. This review focuses on the prevalence of HCC, different types of liver cancer and the staging of the disease, along with available treatment methods. Additionally, explores recent and relevant studies on smart drug- and gene-delivery systems specifically designed for HCC. These systems include targeted endogenous and exogenous stimuli-responsive platforms.<b>Plain language summary: </b>Liver cancer is the third leading cause of cancer deaths in the world that is usually diagnosed in the last stages. Chemotherapy is commonly used to treat advanced liver cancer, but it faces several challenges that reduce its effectiveness. These challenges include low specificity (not targeting cancer cells specifically), high dosage requirements and side effects that can affect anywhere in the body. As a result, the efficacy of chemotherapy is significantly limited, making it difficult to treat liver cancer. This review discusses the prevalence of liver cancer, different types of liver cancer and how the disease is staged. It also explores various treatment methods available for liver cancer. Furthermore, the article explores recent and relevant studies on smart drug- and gene-delivery systems that are specifically designed to target liver cancer. These systems include platforms that respond to targeted and internal or external stimuli. They aim to improve the effectiveness of treatment for liver cancer.
DOI: 10.25549/examiner-c44-17489
title: Landslide...Santa Monica (3750 tons of earth fall on Highway near Palisades), 1951

description: 6 images. Landslide...Santa Monica (3750 tons of earth fall on Highway near Palisades), 20 August 1951. Isaac Fife; Brenda Lee Watts -- 11 years; Robert Watts -- 8 years.; Caption slip reads: "Photographer: Gaze. Date: 1951-08-20. Reporter: Gaze. Assignment: landslide -- Santa Monica. #46: Long shot of slide of 3750 tons of earth from Palisades Park Bluff onto Highway 101. #71: Another view of slide with auto of Isaac Fife, 1409 Victoria Avenue, Los Angeles, pushed 35 feet from its parking place. #87: Brenda Lee Watts, 11; her brother, Robert, 8; and their grandfather, Isaac Fife, beside damaged car".
DOI: 10.25402/nnm.24611970
title: Biogenic synthesis of gold nanoparticles using dual extract of tulsi–Vinca for breast cancer tumor regression in mice - supplementary material

description: <b>Aim: </b>This work aims to synthesize the gold nanoparticles (GNPs) using a dual extract of tulsi and <i>Vinca </i>(T<b>+</b>V-Gold) for breast cancer tumor regression. <b>Methods: </b>The GNPs were synthesized and characterized for their microscopic, spectroscopic and crystalline properties. Further, the GNPs were investigated for <i>in vitro </i>and <i>in vivo </i>studies for the treatment of the 4T1-induced triple-negative breast cancer murine model. <b>Results: </b>The GNPs for 4T1 tumor-challengedmice resulted in delayed tumor development and lower tumor burden, with T<b>+</b>V-Gold demonstrating the highest prevention of tumor spread. The antitumor effect of T<b>+</b>V-Gold is highly significant in the glutathione family antioxidants glutathione S-transferase and glutathione in tumor tissue samples. <b>Conclusion: </b>The bioefficacy and anticancer outcomes of T<b>+</b>V-Gold nanoformulation can be used as therapeutic agents, and drug-delivery vehicles.
DOI: 10.25402/nnm.24611970.v1
title: Biogenic synthesis of gold nanoparticles using dual extract of tulsi–Vinca for breast cancer tumor regression in mice - supplementary material

description: <b>Aim: </b>This work aims to synthesize the gold nanoparticles (GNPs) using a dual extract of tulsi and <i>Vinca </i>(T<b>+</b>V-Gold) for breast cancer tumor regression. <b>Methods: </b>The GNPs were synthesized and characterized for their microscopic, spectroscopic and crystalline properties. Further, the GNPs were investigated for <i>in vitro </i>and <i>in vivo </i>studies for the treatment of the 4T1-induced triple-negative breast cancer murine model. <b>Results: </b>The GNPs for 4T1 tumor-challengedmice resulted in delayed tumor development and lower tumor burden, with T<b>+</b>V-Gold demonstrating the highest prevention of tumor spread. The antitumor effect of T<b>+</b>V-Gold is highly significant in the glutathione family antioxidants glutathione S-transferase and glutathione in tumor tissue samples. <b>Conclusion: </b>The bioefficacy and anticancer outcomes of T<b>+</b>V-Gold nanoformulation can be used as therapeutic agents, and drug-delivery vehicles.
DOI: 10.25402/nnm.24763473
title: Engineering extracellular vesicles mimetics for targeted chemotherapy of drug-resistant ovary cancer - supplementary dataset

description: <b>Aim: </b>To develop nanocarriers for targeting the delivery of chemotherapeutics to overcome multidrug resistant ovarian cancer. <b>Materials & methods: </b>Doxorubicin-loaded nanovesicles were obtained through serial extrusion, followed by loading of P-glycoprotein siRNA and folic acid. The targeting ability and anticancer efficacy of the nanovesicles were evaluated. <b>Results: </b>The doxorubicin-loaded nanovesicles showed a high production yield. The presence of P-glycoprotein siRNA and folic acid resulted in reversed drug resistance and tumor targeting. This nanoplatform tremendously inhibited the viability of multidrug resistant ovarian cancer cells, which was able to target tumor tissue and suppress tumor growth without adverse effects. <b>Conclusion: </b>These bioengineered nanovesicles could serve as novel extracellular vesicles mimetics for chemotherapeutics delivery to overcome multidrug resistance.<b>Plain language summary: </b>When treating cancer affecting the ovaries, which is an organ in the female reproductive system, two challenges that arise are the inefficient delivery of chemotherapeutic drugs and the development of drug resistance inside the tumor. In this study, very small nano-scale particles called nanovesicles, which contain a chemotherapeutic drug called doxorubicin, were developed in an attempt to overcome both of these concerns. These nanovesicles were secreted by a healthy cell from an ovary, isolated and loaded with doxorubicin. These nanovesicles were also loaded with siRNA, which, in this case, prevents the synthesis of a protein in ovarian tumor cells called P-glycoprotein. This protein is responsible for pumping chemotherapy drugs back out of tumor cells, so preventing its synthesis was intended to counter chemotherapeutic resistance. The targeting ability of the nanovesicle was also enhanced with folic acid, as folic acid receptors are present on the surface of these tumor cells in higher numbers. These nanovesicles were readily and specifically taken up by ovarian tumor cells in mice with induced ovarian cancer. This reversed drug resistance and enhanced the toxic effects of doxorubicin on the tumor cells, which, in turn, increased tumor cell death and prevented tumor cell migration. No obvious adverse effect was found in mice treated with the nanovesicle system compared with the free chemotherapy drug with critical systematic toxicity. This research provides new avenues for ovarian cancer treatment, with combined therapies of siRNAs and chemotherapeutic drugs, targeted to tumor cells specifically, within nanovesicles.
DOI: 10.25549/examiner-c44-73322
title: Murder (Di Francisco), 1957

description: 3 images. Murder (Di Francisco), 10 December 1957. Cecil Robert Leighty (stabbed her to death); Mrs. Joy Lazatti -- 24 years (turned him in).; Caption slip reads: "Photographer: Snow. Date: 1957-12-10. Reporter: Waymire. Assignment: Murder (Di Francisco). Cecil Robert Leighty, 24, confessed killer. Mrs. Joy Lazatti, 24, who turned him in".
DOI: 10.25402/nnm.24763473.v1
title: Engineering extracellular vesicles mimetics for targeted chemotherapy of drug-resistant ovary cancer - supplementary dataset

description: <b>Aim: </b>To develop nanocarriers for targeting the delivery of chemotherapeutics to overcome multidrug resistant ovarian cancer. <b>Materials & methods: </b>Doxorubicin-loaded nanovesicles were obtained through serial extrusion, followed by loading of P-glycoprotein siRNA and folic acid. The targeting ability and anticancer efficacy of the nanovesicles were evaluated. <b>Results: </b>The doxorubicin-loaded nanovesicles showed a high production yield. The presence of P-glycoprotein siRNA and folic acid resulted in reversed drug resistance and tumor targeting. This nanoplatform tremendously inhibited the viability of multidrug resistant ovarian cancer cells, which was able to target tumor tissue and suppress tumor growth without adverse effects. <b>Conclusion: </b>These bioengineered nanovesicles could serve as novel extracellular vesicles mimetics for chemotherapeutics delivery to overcome multidrug resistance.<b>Plain language summary: </b>When treating cancer affecting the ovaries, which is an organ in the female reproductive system, two challenges that arise are the inefficient delivery of chemotherapeutic drugs and the development of drug resistance inside the tumor. In this study, very small nano-scale particles called nanovesicles, which contain a chemotherapeutic drug called doxorubicin, were developed in an attempt to overcome both of these concerns. These nanovesicles were secreted by a healthy cell from an ovary, isolated and loaded with doxorubicin. These nanovesicles were also loaded with siRNA, which, in this case, prevents the synthesis of a protein in ovarian tumor cells called P-glycoprotein. This protein is responsible for pumping chemotherapy drugs back out of tumor cells, so preventing its synthesis was intended to counter chemotherapeutic resistance. The targeting ability of the nanovesicle was also enhanced with folic acid, as folic acid receptors are present on the surface of these tumor cells in higher numbers. These nanovesicles were readily and specifically taken up by ovarian tumor cells in mice with induced ovarian cancer. This reversed drug resistance and enhanced the toxic effects of doxorubicin on the tumor cells, which, in turn, increased tumor cell death and prevented tumor cell migration. No obvious adverse effect was found in mice treated with the nanovesicle system compared with the free chemotherapy drug with critical systematic toxicity. This research provides new avenues for ovarian cancer treatment, with combined therapies of siRNAs and chemotherapeutic drugs, targeted to tumor cells specifically, within nanovesicles.
DOI: 10.25402/nnm.24786414
title: Delineating effect of headgroup and preparation method on transfection versus toxicity of DNA-loaded lipid nanocarriers - supplementary materials

description: <b>Aim: </b>To perform a parallel comparison of key parameters affecting the safety and efficiency of lipidbased nanovectors (i.e., complexing headgroups, composition and preparation method). <b>Materials & methods: </b>Various cationic and ionizable headgroups were screened for formulating lipoplexes with GFP– plasmid DNA. Ethanol injection and microfluidics were used to prepare nanoparticles with GFP–plasmid DNA complexed on the surface or within the interior of lipid bilayers. <b>Results: </b>Lipoplexes composed of sphingomyelin 102 exhibited the highest transfection efficiency given their higher cellular uptake in BRAF inhibitor-resistant melanoma cells. Lipid nanoparticles demonstrated acceptable transfection efficiency and high spheroid penetration while protecting plasmid DNA under simulated physiological conditions. <b>Conclusion: </b>Selecting the right complexing lipid and preparation method is critical for developing lipid nanocarriers to treat intractable diseases.<b>Plain language summary: </b>Certain genetic diseases or cancers can be treated with gene therapy. This involves the delivery of working genes to cells with a faulty copy. These genes are often contained in a circular piece of DNA called a plasmid. Plasmids can be delivered by a variety of structures called vectors. These vectors include altered viruses as well as lipid-based nanovectors, which are nanoscale spheres of phospholipids, a type of fat. Plasmids can either be internalized inside these spheres in lipid nanoparticles (LNPs) or attached to the surface in nanocomplexes. A section of the phospholipid called the headgroup faces outward in lipid-based nanovectors. The chemical makeup of these headgroups determines the function of the lipid-based nanovector. This study aimed to determine an optimal lipid-based nanovector in gene delivery by testing a variety and identifying which was most effective at delivering a gene that makes cells fluoresce green when successfully delivered. The more intense the fluorescence, the greater the degree of successful gene delivery. This study found that LNPs were more effective at delivering plasmid DNA than nanocomplexes and were safer and protected plasmid DNA better. The best performing LNP contained the lipid sphingomyelin 102, which is biodegradable. Therefore, the optimized LNP formulation employing sphingomyelin 102 as a biodegradable lipid could be an efficient nonviral gene-delivery system and will be further investigated to target drug-resistant melanoma, a type of skin cancer.
DOI: 10.25402/nnm.24786414.v1
title: Delineating effect of headgroup and preparation method on transfection versus toxicity of DNA-loaded lipid nanocarriers - supplementary materials

description: <b>Aim: </b>To perform a parallel comparison of key parameters affecting the safety and efficiency of lipidbased nanovectors (i.e., complexing headgroups, composition and preparation method). <b>Materials & methods: </b>Various cationic and ionizable headgroups were screened for formulating lipoplexes with GFP– plasmid DNA. Ethanol injection and microfluidics were used to prepare nanoparticles with GFP–plasmid DNA complexed on the surface or within the interior of lipid bilayers. <b>Results: </b>Lipoplexes composed of sphingomyelin 102 exhibited the highest transfection efficiency given their higher cellular uptake in BRAF inhibitor-resistant melanoma cells. Lipid nanoparticles demonstrated acceptable transfection efficiency and high spheroid penetration while protecting plasmid DNA under simulated physiological conditions. <b>Conclusion: </b>Selecting the right complexing lipid and preparation method is critical for developing lipid nanocarriers to treat intractable diseases.<b>Plain language summary: </b>Certain genetic diseases or cancers can be treated with gene therapy. This involves the delivery of working genes to cells with a faulty copy. These genes are often contained in a circular piece of DNA called a plasmid. Plasmids can be delivered by a variety of structures called vectors. These vectors include altered viruses as well as lipid-based nanovectors, which are nanoscale spheres of phospholipids, a type of fat. Plasmids can either be internalized inside these spheres in lipid nanoparticles (LNPs) or attached to the surface in nanocomplexes. A section of the phospholipid called the headgroup faces outward in lipid-based nanovectors. The chemical makeup of these headgroups determines the function of the lipid-based nanovector. This study aimed to determine an optimal lipid-based nanovector in gene delivery by testing a variety and identifying which was most effective at delivering a gene that makes cells fluoresce green when successfully delivered. The more intense the fluorescence, the greater the degree of successful gene delivery. This study found that LNPs were more effective at delivering plasmid DNA than nanocomplexes and were safer and protected plasmid DNA better. The best performing LNP contained the lipid sphingomyelin 102, which is biodegradable. Therefore, the optimized LNP formulation employing sphingomyelin 102 as a biodegradable lipid could be an efficient nonviral gene-delivery system and will be further investigated to target drug-resistant melanoma, a type of skin cancer.
DOI: 10.25549/examiner-c44-52526
title: Scout mother's camp out (Altadena), 1958

description: 10 images. Scout mother's camp out (Altadena), 27 June 1958. Mrs. Richard Bailey; Mrs. Paul East; Mrs. D.J. Crumb; Mrs. Robert Bernhard; Mrs. Henry W. Snyder; Mrs. Frank J. Ziol; Mrs. Kenneth Coombs; Mrs. Maurice Pitzer; Mrs. John Kepler; Mrs. Don Lewis; Mrs. Clyde Martin; Mrs. Lou Burstein; Mrs. Thomas Dublin; Mrs. Lee A. Berry; Mrs. Morris Outwater; Mrs. Harold Beveridge; Mrs. George Becker; Mrs. Robert Kahn; Mrs. Joe Barlow.; Caption slip reads: "Photographer: Swaim. Date: 1958-06-27. Reporter: Swaim. Assignment: Scout mother's camp out. Camp Huntington, Altadena. 12: Mrs. Lou Berstein, left, past pres., and Mrs. Thomas Dublin, 1st vice-pres. arriving for 17th annual campout [sic] of Federation of Mothers' Auxiliaries, San Gabriel Council, Boy Scouts. 4: L to R, Mrs. Ancel A. Horn, past pres., Mrs. Thomas Dublin 1st VP, and Mrs. Lee A. Berry, president, starting cookout for their campout [sic]. 9: Mrs. Morris Outwater, Mrs. Harold Beveridge, Mrs. George Becker and Mrs. Robert Kahn, cooking steaks, corn, etc. 10: Mrs. Joe Barlow munching on ear of corn. 19: Mrs. Richard Bailey, left, and Mrs. Paul East cooking steaks. 25/26: 'Purple people eaters' getting costume for skit at campout. L to R, Mrs. D.J. Crumb (sitting on log), Mrs. Robert Bernhard (peeking out of back of costume), Mrs. Henry W. Snyder, having custome [sic] arranged by Mrs. Frank J. Ziol. All are from Troop 4, Pasadena. 20: L to R, Mrs. Kenneth Coombs, Mrs. Maurice Pitzer, and Mrs. John Kepler making salad. 5: Mrs. Don Lewis (top) and Mrs. Clyde Martin (under), improvising table as a double bunk to get off ground away from animals, snakes, etc. 6: Same Mrs. Don Lewis and Mrs. Clyde Martin, add (l to r) Mrs. Paul East, Mrs. Herman Luebke, on horse, and Mrs. Richard Bailey".
DOI: 10.15468/dl.9ekwtb
title: Occurrence Download

description: A dataset containing 691415 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Poa annua L.)"
 ]
}

 The dataset includes 691415 records from 3470 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017262-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zn4jho
title: Occurrence Download

description: A dataset containing 9902 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is DSMZ Bacteria"
 ]
}

 The dataset includes 9902 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011701-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.32w2qn
title: Occurrence Download

description: A dataset containing 148 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Brassavola cucullata (L.) R.Br."
 ]
}

 The dataset includes 148 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0296035-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5yhuqv
title: Occurrence Download

description: A dataset containing 369 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Pelobates syriacus Boettger, 1889"
 ]
}

 The dataset includes 369 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045266-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7juwzz
title: Occurrence Download

description: A dataset containing 326 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Gampsorhynchus torquatus Hume, 1874"
 ]
}

 The dataset includes 326 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011701-171219132708484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.km9sgx
title: Occurrence Download

description: A dataset containing 197 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Macroalgas, equinodermos y crustáceos de la Isla Cayo Serranilla durante la Expedición Seaflower 2017 - Proyecto Colombia BIO"
 ]
}

 The dataset includes 197 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003867-190307172214381/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6ndatc
title: Occurrence Download

description: A dataset containing 131544 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Material sample, Specimen, Material citation)",
 "Geometry POLYGON((-75.7703 22.68583,-84.24308 24.2303,-111.38617 21.96954,-79.21387 -57.25166,-56.90081 -57.25166,-24.61809 -29.80223,-18.68376 -5.83577,-61.28999 19.09476,-73.88082 26.11053,-77.41185 25.63634,-79.30912 24.8259,-78.20238 23.55195,-75.7703 22.68583))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is one of (Dipsadidae, Colubridae, Tropidophiidae, Elapidae, Viperidae, Pseudoxenodontidae, Typhlopidae, Lamprophiidae, Pythonidae, Leptotyphlopidae, Boidae, Natricidae, Uropeltidae, Xenopeltidae, Homalopsidae, Acrochordidae, Anomalepididae, Aniliidae, Anomochilidae, Bolyeridae, Cylindrophiidae, Xenopeltis Reinwardt, 1827, Loxocemidae, Atractaspididae, Cyclocoridae, Prosymnidae, Psammophiidae, Pseudaspididae, Pseudoxyrhophiidae, Gerrhopilidae, Xenotyphlopidae, Pareidae, Xenodermidae, Xenophidiidae)"
 ]
}

 The dataset includes 131544 records from 262 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045186-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3bdrcv
title: Occurrence Download

description: A dataset containing 46863 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Coronilla varia L."
 ]
}

 The dataset includes 46863 records from 353 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0284293-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gfjolp
title: Occurrence Download

description: A dataset containing 20960 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sagittarius serpentarius (J.F.Miller, 1779)"
 ]
}

 The dataset includes 20960 records from 71 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011702-171219132708484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.