cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11835759
title: Supplementary Material for: Clozapine-Associated Obsessive-Compulsive Symptoms and Their Management: A Systematic Review and Analysis of 107 Reported Cases

description: <b><i>Background:</i></b> It is not uncommon to find obsessive-compulsive symptoms (OCS) in patients treated with clozapine. These symptoms are attributed to anti-serotonergic effects of clozapine. The objective of this study was to conduct a systematic review of reported cases of clozapine-associated OCS to better understand the nature and management of these symptoms. <b><i>Methods:</i></b> MEDLINE, Embase, and PsycINFO databases were searched with no publication year or language restrictions. Studies reporting cases of clozapine-associated OCS, either de novo or exacerbation of preexisting OCS, were included. The final search date was July 11, 2019. <b><i>Results:</i></b> Fifty-seven studies, involving 107 cases (75 de novo, 32 exacerbated OCS), were included. Clozapine triggered moderate-severe OCS at varying doses (100–900 mg/day) and treatment durations (median 6 months, interquartile range 2–24 months). Higher severity was significantly associated with preexisting OCS, poorer insight into OCS, and active psychosis at the time of OCS. Common strategies to treat clozapine-associated OCS included adding selective serotonin reuptake inhibitors, clomipramine, or aripiprazole, often accompanied by clozapine dose reduction. The rate of response to antidepressants was 49% (29/59), where younger age, shorter duration of underlying illness, shorter cloza­pine treatment duration, better insight into OCS, and presence of taboo thoughts were significantly associated with antidepressant response. Subsequent clozapine dose reduction was effective in many non-responders, where aripiprazole was simultaneously added in 50% (8/16). <b><i>Conclusions:</i></b> Clozapine can trigger severe OCS. Adding aripiprazole with/without clozapine dose reduction may be a good alternative to antidepressants for managing clozapine-associated OCS. Clinicians should be more vigilant about these adverse effects and administer appropriate treatments.
DOI: 10.6084/m9.figshare.11835765
title: Supplementary Material for: Physical Activity, Hormone Therapy Use, and Stroke Risk among Women in the California Teachers Study Cohort

description: <b><i>Background:</i></b> Postmenopausal hormone therapy (HT) increases the risk of stroke. Here we evaluate whether leisure time physical activity (LTPA) can change stroke risk in women using HT, leveraging data from the California Teachers Study. <b><i>Methods:</i></b> Female California educators without a prior history of stroke (<i>n</i> = 118,294) were followed from 1995 through 2015 for stroke end points. Based on statewide hospitalization data, 4,437 women had ischemic (<i>n</i> = 3,162; International Classification of Diseases [ICD]-9 433, 434, 436) or hemorrhagic (<i>n</i> = 1,275; ICD-9 430–432, excluding 432.1) stroke. LTPA and HT use were evaluated at 2 time points (baseline [1995–1996] and 10-year follow-up [2005–2006]). LTPA was assessed using American Heart Association (AHA) recommendations (&gt;150 min/week moderate or &gt;75 min/week strenuous physical activity). Using multivariable Cox proportional hazards models, we estimated the hazard ratios (HRs) and 95% CIs for the associations between HT use and concurrent LTPA with incident stroke. <b><i>Results:</i></b> Compared to women who never used HT, stroke risk was highest among women who were current HT users and did not meet AHA recommendations for LTPA at the time of their HT use: HR<sub>baseline</sub> 1.28 (95% CI 1.13–1.44); HR<sub>10-year follow-up</sub> 1.17 (95% CI 0.91–1.50). Based on the baseline questionnaire, current HT users who met AHA recommendations for LTPA in 1995–1996 still had elevated stroke risk in the 20-year follow-up (HR 1.22, 95% CI 1.08–1.37). However, among current HT users who met AHA recommendations for LTPA at the 2005–2006 follow-up questionnaire, stroke risk was not elevated (HR 1.01, 95% CI 0.80–1.29). Evaluation of the 2 time points in concert further demonstrated that meeting AHA recommendations for LTPA at the most recent follow-up time point was required to reduce HT-related stroke risk. <b><i>Conclusion:</i></b> Concurrent physical activity may attenuate the short-term increase in risk of stroke risk associated with HT use.
DOI: 10.6084/m9.figshare.11835759.v1
title: Supplementary Material for: Clozapine-Associated Obsessive-Compulsive Symptoms and Their Management: A Systematic Review and Analysis of 107 Reported Cases

description: <b><i>Background:</i></b> It is not uncommon to find obsessive-compulsive symptoms (OCS) in patients treated with clozapine. These symptoms are attributed to anti-serotonergic effects of clozapine. The objective of this study was to conduct a systematic review of reported cases of clozapine-associated OCS to better understand the nature and management of these symptoms. <b><i>Methods:</i></b> MEDLINE, Embase, and PsycINFO databases were searched with no publication year or language restrictions. Studies reporting cases of clozapine-associated OCS, either de novo or exacerbation of preexisting OCS, were included. The final search date was July 11, 2019. <b><i>Results:</i></b> Fifty-seven studies, involving 107 cases (75 de novo, 32 exacerbated OCS), were included. Clozapine triggered moderate-severe OCS at varying doses (100–900 mg/day) and treatment durations (median 6 months, interquartile range 2–24 months). Higher severity was significantly associated with preexisting OCS, poorer insight into OCS, and active psychosis at the time of OCS. Common strategies to treat clozapine-associated OCS included adding selective serotonin reuptake inhibitors, clomipramine, or aripiprazole, often accompanied by clozapine dose reduction. The rate of response to antidepressants was 49% (29/59), where younger age, shorter duration of underlying illness, shorter cloza­pine treatment duration, better insight into OCS, and presence of taboo thoughts were significantly associated with antidepressant response. Subsequent clozapine dose reduction was effective in many non-responders, where aripiprazole was simultaneously added in 50% (8/16). <b><i>Conclusions:</i></b> Clozapine can trigger severe OCS. Adding aripiprazole with/without clozapine dose reduction may be a good alternative to antidepressants for managing clozapine-associated OCS. Clinicians should be more vigilant about these adverse effects and administer appropriate treatments.
DOI: 10.6084/m9.figshare.11835765.v1
title: Supplementary Material for: Physical Activity, Hormone Therapy Use, and Stroke Risk among Women in the California Teachers Study Cohort

description: <b><i>Background:</i></b> Postmenopausal hormone therapy (HT) increases the risk of stroke. Here we evaluate whether leisure time physical activity (LTPA) can change stroke risk in women using HT, leveraging data from the California Teachers Study. <b><i>Methods:</i></b> Female California educators without a prior history of stroke (<i>n</i> = 118,294) were followed from 1995 through 2015 for stroke end points. Based on statewide hospitalization data, 4,437 women had ischemic (<i>n</i> = 3,162; International Classification of Diseases [ICD]-9 433, 434, 436) or hemorrhagic (<i>n</i> = 1,275; ICD-9 430–432, excluding 432.1) stroke. LTPA and HT use were evaluated at 2 time points (baseline [1995–1996] and 10-year follow-up [2005–2006]). LTPA was assessed using American Heart Association (AHA) recommendations (&gt;150 min/week moderate or &gt;75 min/week strenuous physical activity). Using multivariable Cox proportional hazards models, we estimated the hazard ratios (HRs) and 95% CIs for the associations between HT use and concurrent LTPA with incident stroke. <b><i>Results:</i></b> Compared to women who never used HT, stroke risk was highest among women who were current HT users and did not meet AHA recommendations for LTPA at the time of their HT use: HR<sub>baseline</sub> 1.28 (95% CI 1.13–1.44); HR<sub>10-year follow-up</sub> 1.17 (95% CI 0.91–1.50). Based on the baseline questionnaire, current HT users who met AHA recommendations for LTPA in 1995–1996 still had elevated stroke risk in the 20-year follow-up (HR 1.22, 95% CI 1.08–1.37). However, among current HT users who met AHA recommendations for LTPA at the 2005–2006 follow-up questionnaire, stroke risk was not elevated (HR 1.01, 95% CI 0.80–1.29). Evaluation of the 2 time points in concert further demonstrated that meeting AHA recommendations for LTPA at the most recent follow-up time point was required to reduce HT-related stroke risk. <b><i>Conclusion:</i></b> Concurrent physical activity may attenuate the short-term increase in risk of stroke risk associated with HT use.
DOI: 10.6084/m9.figshare.11835774.v1
title: Supplementary Material for: Pregnancy-Related Acute Kidney Injury in the United States: Clinical Outcomes and Health Care Utilization

description: <b><i>Background:</i></b> Acute kidney injury (AKI) during pregnancy is a public health problem and is associated with maternal and fetal morbidity and mortality. Clinical outcomes and health care utilization in pregnancy-related AKI, especially in women with diabetes, are not well studied. <b><i>Methods:</i></b> Using data from the 2006 to 2015 Nationwide Inpatient Sample, we identified 42,190,790 pregnancy-related hospitalizations in women aged 15–49 years. We determined factors associated with AKI, including race/ethnicity, and associations between AKI and inpatient mortality, and between AKI and cardiovascular (CV) events, during pregnancy-related hospitalizations. We calculated health care expenditures from pregnancy-related AKI hospitalizations. <b><i>Results:</i></b> Overall, the rate of AKI during pregnancy-related hospitalizations was 0.08%. In the adjusted regression analysis, a higher likelihood of AKI during pregnancy-related hospitalizations was seen in 2015 (OR 2.20; 95% CI 1.89–2.55) than in 2006; in older women aged 36–40 years (OR 1.49; 95% CI 1.36–1.64) and 41–49 years (OR 2.12; 95% CI 1.84–2.45) than in women aged 20–25 years; in blacks (OR 1.52; 95% CI 1.40–1.65) and Native Americans (OR 1.45; 95% CI 1.10–1.91) than in whites, and in diabetic women (OR 4.43; 95% CI 4.04–4.86) than in those without diabetes. Pregnancy-related hospitalizations with AKI were associated with a higher likelihood of inpatient mortality (OR 13.50; 95% CI 10.47–17.42) and CV events (OR 9.74; 95% CI 9.08–10.46) than were hospitalizations with no AKI. The median cost was higher for a delivery hospitalization with AKI than without AKI (USD 18,072 vs. 4,447). <b><i>Conclusion:</i></b> The rates of pregnancy-related AKI hospitalizations have increased during the last decade. Factors associated with a higher likelihood of AKI during pregnancy included older age, black and Native American race/ethnicity, and diabetes. Hospitalizations with pregnancy-related AKI have an increased risk of inpatient mortality and CV events, and a higher health care utilization than do those without AKI.
DOI: 10.6084/m9.figshare.11835735
title: Supplementary Material for: Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates

description: <b><i>Introduction:</i></b> Quality measures for colonoscopy such as adenoma detection rate (ADR) have been proposed to be surveilled for ensuring minimum standards. However, its direct measurement is time consuming and often neglected. Extrapolating ADR and other quality measures from polyp detection rate (PDR) can be a pragmatic alternative. <b><i>Objective:</i></b> To determine quotients for estimating ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) from PDR in an Australian cohort. <b><i>Methods:</i></b> Consecutive adult patient colonoscopies during a 1-year period were retrospectively assessed in a single Australian tertiary endoscopy center. Adenoma detection quotient (ADQ) and SSA/P detection quotient (SSA/P-DQ) were defined as the division of ADR and SSA/P-DR by PDR, respectively. The primary outcome was the number of procedures to achieve a stable cumulative ADQ and SSA/P-DQ. Secondary outcomes included evaluation of ADQ and SSA/P-DQ in different subsets. <b><i>Results:</i></b> In total, 2,657 colonoscopies were performed by 15 endoscopists in 2016. The ADR, SSA/P-DR, and PDR found were 32.2, 6.7, and 47.3%, respectively. The ADQ and SSA/P-DQ values found were 0.68 and 0.14, respectively. After approximately 500 procedures, both ADQ and SSA/P-DQ became stable. Interclass correlation coefficient (ICC) for the prediction of ADR from ADQ was excellent for all endoscopists that performed &gt;177 procedures in that year (ICC 0.84). <b><i>Conclusions:</i></b> ADQ and SSA/P-DQ values were consistent when over 500 procedures were analyzed. ADQ had an excellent correlation with ADR when &gt;177 procedures per endoscopist were evaluated.
DOI: 10.6084/m9.figshare.11835735.v1
title: Supplementary Material for: Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates

description: <b><i>Introduction:</i></b> Quality measures for colonoscopy such as adenoma detection rate (ADR) have been proposed to be surveilled for ensuring minimum standards. However, its direct measurement is time consuming and often neglected. Extrapolating ADR and other quality measures from polyp detection rate (PDR) can be a pragmatic alternative. <b><i>Objective:</i></b> To determine quotients for estimating ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) from PDR in an Australian cohort. <b><i>Methods:</i></b> Consecutive adult patient colonoscopies during a 1-year period were retrospectively assessed in a single Australian tertiary endoscopy center. Adenoma detection quotient (ADQ) and SSA/P detection quotient (SSA/P-DQ) were defined as the division of ADR and SSA/P-DR by PDR, respectively. The primary outcome was the number of procedures to achieve a stable cumulative ADQ and SSA/P-DQ. Secondary outcomes included evaluation of ADQ and SSA/P-DQ in different subsets. <b><i>Results:</i></b> In total, 2,657 colonoscopies were performed by 15 endoscopists in 2016. The ADR, SSA/P-DR, and PDR found were 32.2, 6.7, and 47.3%, respectively. The ADQ and SSA/P-DQ values found were 0.68 and 0.14, respectively. After approximately 500 procedures, both ADQ and SSA/P-DQ became stable. Interclass correlation coefficient (ICC) for the prediction of ADR from ADQ was excellent for all endoscopists that performed &gt;177 procedures in that year (ICC 0.84). <b><i>Conclusions:</i></b> ADQ and SSA/P-DQ values were consistent when over 500 procedures were analyzed. ADQ had an excellent correlation with ADR when &gt;177 procedures per endoscopist were evaluated.
DOI: 10.17028/rd.lboro.11835693
title: Bibliography of periodical contributions by George Eliot, Frances Milton Trollope, Frances Eleanor Trollope, Thomas Adolphus Trollope, and Theodosia Garrow Trollope

description: Excel file comprising 4 sheets. These are also available as individual .csv files:<br>Attributions_Periodical: Gives the bibliographic information concerning all works that I have been able to source for each of the authors in question, including whether the piece was published anonymously or not.Attributions_Periodical_No-TAT-or-TGT: A duplicate of the above sheet, with the work of Thomas Adolphus Trollope and Theodosia Garrow Trollope removed.Periodical_Info: Information about the periodicals listed in the bibliography, including dates of issue, editors, publishers, and proprietors.Other_Wellesley_Attributions: Pieces found in the <i>Wellesley Index</i> that concern the authors written by others.Suspected_Periodical_Attributions: Works that I suspect were written by one of the authors but are not attributed to them in the <i>Wellesley</i> or <i> Curran</i> indices.
DOI: 10.17028/rd.lboro.11835693.v2
title: Bibliography of periodical contributions by George Eliot, Frances Milton Trollope, Frances Eleanor Trollope, Thomas Adolphus Trollope, and Theodosia Garrow Trollope

description: Excel file comprising 4 sheets. These are also available as individual .csv files:<br>Attributions_Periodical: Gives the bibliographic information concerning all works that I have been able to source for each of the authors in question, including whether the piece was published anonymously or not.Attributions_Periodical_No-TAT-or-TGT: A duplicate of the above sheet, with the work of Thomas Adolphus Trollope and Theodosia Garrow Trollope removed.Periodical_Info: Information about the periodicals listed in the bibliography, including dates of issue, editors, publishers, and proprietors.Other_Wellesley_Attributions: Pieces found in the <i>Wellesley Index</i> that concern the authors written by others.Suspected_Periodical_Attributions: Works that I suspect were written by one of the authors but are not attributed to them in the <i>Wellesley</i> or <i> Curran</i> indices.
DOI: 10.17028/rd.lboro.11835693.v1
title: Bibliography of periodical contributions by George Eliot, Frances Milton Trollope, Frances Eleanor Trollope, Thomas Adolphus Trollope, and Theodosia Garrow Trollope

description: Excel file comprising 6 sheets. These are also available as individual .csv files:<br>Attributions_Periodical: Gives the bibliographic information concerning all works that I have been able to source for each of the authors in question, including whether the piece was published anonymously or not.F-E-T_Novel_Parts_Individual: Gives information about each individual issue of Frances Eleanor Trollope's fiction published in periodicals.F-E-T_Novel_Parts_Together: Gives information about Frances Eleanor Trollope's fiction published in periodicals with novels synthesised in a single line.Periodical_Info: Information about the periodicals listed in the bibliography, including dates of issue, editors, publishers, and proprietors.Other_Wellesley_Attributions: Pieces found in the <i>Wellesley Index</i> that concern the authors written by others.Suspected_Periodical_Attributions: Works that I suspect were written by one of the authors but are not attributed to them in the <i>Wellesley</i> or <i> Curran</i> indices.
DOI: 10.6084/m9.figshare.11835633
title: Supplementary data: for Harris et al. Full spectra colouration and condition-dependent signalling in a skin-based carotenoid sexual ornament.

description: This dataset contains the reflectance spectra (320-700nm) of male black grouse, along with dependent variables and random effects use in analysis. The file contains two sheets -the data, and a sheet describing the headers.
DOI: 10.6084/m9.figshare.11835636
title: Transcriptome data of tea variety zhenong 139 under 10 mg / L fluoride stress (first leaf, fifth leaf and root)

description: Transcriptome data of tea variety zhenong 139 under 10 mg / L fluoride stress (first leaf, fifth leaf and root)
DOI: 10.6084/m9.figshare.11835663
title: DurumWheat259indx7817sites.vcf

description: Filtered SNP variants of 259 durum wheat accessions in VCF v4.2 format. For details on SNP calling and filtering, please see M&M of the manuscript titled: "Whole genome scan reveals molecular signatures of divergence and selection related to important traits in durum wheat germplasm".
DOI: 10.6084/m9.figshare.11835633.v1
title: Supplementary data: for Harris et al. Full spectra colouration and condition-dependent signalling in a skin-based carotenoid sexual ornament.

description: This dataset contains the reflectance spectra (320-700nm) of male black grouse, along with dependent variables and random effects use in analysis. The file contains two sheets -the data, and a sheet describing the headers.
DOI: 10.6084/m9.figshare.11835636.v1
title: Transcriptome data of tea variety zhenong 139 under 10 mg / L fluoride stress (first leaf, fifth leaf and root)

description: Transcriptome data of tea variety zhenong 139 under 10 mg / L fluoride stress (first leaf, fifth leaf and root)
DOI: 10.6084/m9.figshare.11835663.v1
title: DurumWheat259indx7817sites.vcf

description: Filtered SNP variants of 259 durum wheat accessions in VCF v4.2 format. For details on SNP calling and filtering, please see M&M of the manuscript titled: "Whole genome scan reveals molecular signatures of divergence and selection related to important traits in durum wheat germplasm".
DOI: 10.6084/m9.figshare.11835396
title: Additional file 2 of Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population

description: Additional file 2: Table S2. Haplotype estimation for five high frequency BRCA1 SNVs in three different Cancer Centers in Brazil. Here we show only haplotypes with frequencies higher than 1%. In red, the haplotype identified as significantly more frequent in the elderly cohort, in our HBOC cohort analysis. In bold, the haplotype that was significantly more frequent in the control group of all three other Brazilian Cancer Centers. HPOA = Hospital das Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; ACC = A.C. Camargo Cancer Center, São Paulo, SP, Brazil; HCB = Barretos Cancer Hospital, Barretos, SP, Brazil. Hp = estimated haplotypes. Hap. freq. = haplotype frequency. p-value = haplotype score statistic p-value calculated by Haplo.stats. NA = when the haplotype score statistic p-value could not be calculated.
DOI: 10.6084/m9.figshare.11835396.v1
title: Additional file 2 of Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population

description: Additional file 2: Table S2. Haplotype estimation for five high frequency BRCA1 SNVs in three different Cancer Centers in Brazil. Here we show only haplotypes with frequencies higher than 1%. In red, the haplotype identified as significantly more frequent in the elderly cohort, in our HBOC cohort analysis. In bold, the haplotype that was significantly more frequent in the control group of all three other Brazilian Cancer Centers. HPOA = Hospital das Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; ACC = A.C. Camargo Cancer Center, São Paulo, SP, Brazil; HCB = Barretos Cancer Hospital, Barretos, SP, Brazil. Hp = estimated haplotypes. Hap. freq. = haplotype frequency. p-value = haplotype score statistic p-value calculated by Haplo.stats. NA = when the haplotype score statistic p-value could not be calculated.
DOI: 10.6084/m9.figshare.11835390
title: Additional file 1 of Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population

description: Additional file 1: Table S1. Clinical characterization of the HBOC cohort. NI = Not-informed; CNS = Central Nervous System. The tumor size, lymph node staging and the metastasis status are reported according to MOC Brazil guidelines for tumor staging (https://mocbrasil.com/).
DOI: 10.6084/m9.figshare.11835390.v1
title: Additional file 1 of Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population

description: Additional file 1: Table S1. Clinical characterization of the HBOC cohort. NI = Not-informed; CNS = Central Nervous System. The tumor size, lymph node staging and the metastasis status are reported according to MOC Brazil guidelines for tumor staging (https://mocbrasil.com/).
DOI: 10.6084/m9.figshare.11835282
title: Additional file 2 of Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

description: Additional file 2: Supplementary dataset 1
DOI: 10.6084/m9.figshare.11835282.v1
title: Additional file 2 of Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

description: Additional file 2: Supplementary dataset 1
DOI: 10.6084/m9.figshare.11835198
title: Additional file 2 of Genotype-by-environment interaction in coast redwood outside natural distribution - search for environmental cues

description: Additional file 2 Phenotypic data. The Additional file 2 contains all phenotypic data used in this study.