cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25934/00005165
title: Reanalysis of CARES study to investigate the incidence of cardiovascular events and death after initiation and discontinuation of allopurinol and febuxostat

description: Gout is the most common inflammatory joint disease and causes pain, swelling, and joint damage. This disease is characterized by chronic hyperuricemia (an abnormally high level of uric acid in the blood) and uric acid crystal deposition in joints. There have been many reports about close association between gout and cardiovascular disease. However, whether hyperuricemia and uric acid crystal directly cause cardiovascular disease is not well known.
 Febuxostat is a highly selective and potent inhibitor of xanthine oxidase, a metabolic pathway for uric acid formation, which has been developed to treat patients with insufficient response to allopurinol. The cardiovascular safety of Febuxostat and Allopurinol in patients with gout and cardiovascular disease (CARES) was evaluated as an FDA requirement to determine whether febuxostat is not inferior to allopurinol in terms of adverse major cardiovascular events. The CARES trial suggested that the incidence of all-cause mortality and cardiovascular death was higher in the febuxostat group than that in the allopurinol group. Consequently, the United States Food and Drug Administration added a boxed warning to febuxostat regarding increased risk of death.
 We previously reanalyzed the CARES trial to calculate the mortality rates based on the median duration of exposure to study drugs and the median follow-up duration. A sharp increase in mortality was observed after allopurinol and febuxostat were discontinued. Even in view of the Sick-Stopper Effect, for about 40-fold increase in mortality following discontinuation of allopurinol and febuxostat, it was concluded that the sharp increase in mortality may be associated with rapid changes in uric acid level (rebound hyperuricemia), risk factor for acute gout attack.
 Based on this idea, we hypothesize that some of cardiovascular events may be cardiovascular gout attacks. Considering that cardiovascular disease is frequently associated with gout, and gout is a very common disease, the outcomes of this study are very important to public health.
DOI: 10.5281/zenodo.8389599
title: Beyond busy workers: Exploring the sensitivity of inactive ants to environmental cues

description: Dataset corresponding to the results displayed in the article "Beyond the busy workers: exploring the sensitivity of inactive ants to environmental cues"
DOI: 10.5281/zenodo.8389598
title: Beyond busy workers: Exploring the sensitivity of inactive ants to environmental cues

description: Dataset corresponding to the results displayed in the article "Beyond the busy workers: exploring the sensitivity of inactive ants to environmental cues"
DOI: 10.6084/m9.figshare.24242476
title: Supplementary Material for: Efficacy of a Self-Directed Video-based Caregiver-Implemented Language Programme

description: Introduction. Caregiver-implemented language programmes are effective for alleviating early language difficulties. This study examined the efficacy of a self-directed video-based caregiver-implement language programme in Chinese families. Method. This study consisted of two stages. In Stage 1, 31 caregiver-child dyads (typically developing children) completed the training programme (Group 1) in the form of six video-based training modules. In Stage 2, 28 caregiver-child dyads (children with language difficulties) receiving active speech therapy were randomly assigned to the training (Group 2) and control arms (Group 3). Group 2 received the same training as Group 1 in addition to their regular therapy while Group 3 was kept as status quo. Caregivers completed a quiz on their knowledge of language facilitation techniques (LFTs) and submitted caregiver-child interaction videos at the start and end of the training. Outcome measures included programme completion rate, quiz scores, and use of LFTs and children’s communication skills in the videos. A pre-post design and a between-group designs were adopted in the Stage 1 and 2 studies respectively. Results. A completion rate of about 60% in both stages was noted. Significantly higher post-training knowledge scores were found in Groups 1 and 2. General but non-significant growth in use of parallel talk and gesture, and significant gains in children’s vocalization in the training arm were observed. Conclusion. The self-directed video-based training programme would be useful in imparting information to caregivers. However, the modest improvements in the use of LFTs suggested direct coaching appeared to still play a significant role in enhancing the actual implementation of LFTs. Further investigation on a larger scale is required to evaluate the effectiveness of the training program for promoting the wider use of this mode as a preventive measure.
DOI: 10.6084/m9.figshare.24242476.v1
title: Supplementary Material for: Efficacy of a Self-Directed Video-based Caregiver-Implemented Language Programme

description: Introduction. Caregiver-implemented language programmes are effective for alleviating early language difficulties. This study examined the efficacy of a self-directed video-based caregiver-implement language programme in Chinese families. Method. This study consisted of two stages. In Stage 1, 31 caregiver-child dyads (typically developing children) completed the training programme (Group 1) in the form of six video-based training modules. In Stage 2, 28 caregiver-child dyads (children with language difficulties) receiving active speech therapy were randomly assigned to the training (Group 2) and control arms (Group 3). Group 2 received the same training as Group 1 in addition to their regular therapy while Group 3 was kept as status quo. Caregivers completed a quiz on their knowledge of language facilitation techniques (LFTs) and submitted caregiver-child interaction videos at the start and end of the training. Outcome measures included programme completion rate, quiz scores, and use of LFTs and children’s communication skills in the videos. A pre-post design and a between-group designs were adopted in the Stage 1 and 2 studies respectively. Results. A completion rate of about 60% in both stages was noted. Significantly higher post-training knowledge scores were found in Groups 1 and 2. General but non-significant growth in use of parallel talk and gesture, and significant gains in children’s vocalization in the training arm were observed. Conclusion. The self-directed video-based training programme would be useful in imparting information to caregivers. However, the modest improvements in the use of LFTs suggested direct coaching appeared to still play a significant role in enhancing the actual implementation of LFTs. Further investigation on a larger scale is required to evaluate the effectiveness of the training program for promoting the wider use of this mode as a preventive measure.
DOI: 10.6084/m9.figshare.24242479
title: Supplementary Material for: Efficacy of a Self-Directed Video-based Caregiver-Implemented Language Programme

description: Introduction. Caregiver-implemented language programmes are effective for alleviating early language difficulties. This study examined the efficacy of a self-directed video-based caregiver-implement language programme in Chinese families. Method. This study consisted of two stages. In Stage 1, 31 caregiver-child dyads (typically developing children) completed the training programme (Group 1) in the form of six video-based training modules. In Stage 2, 28 caregiver-child dyads (children with language difficulties) receiving active speech therapy were randomly assigned to the training (Group 2) and control arms (Group 3). Group 2 received the same training as Group 1 in addition to their regular therapy while Group 3 was kept as status quo. Caregivers completed a quiz on their knowledge of language facilitation techniques (LFTs) and submitted caregiver-child interaction videos at the start and end of the training. Outcome measures included programme completion rate, quiz scores, and use of LFTs and children’s communication skills in the videos. A pre-post design and a between-group designs were adopted in the Stage 1 and 2 studies respectively. Results. A completion rate of about 60% in both stages was noted. Significantly higher post-training knowledge scores were found in Groups 1 and 2. General but non-significant growth in use of parallel talk and gesture, and significant gains in children’s vocalization in the training arm were observed. Conclusion. The self-directed video-based training programme would be useful in imparting information to caregivers. However, the modest improvements in the use of LFTs suggested direct coaching appeared to still play a significant role in enhancing the actual implementation of LFTs. Further investigation on a larger scale is required to evaluate the effectiveness of the training program for promoting the wider use of this mode as a preventive measure.
DOI: 10.6084/m9.figshare.24242479.v1
title: Supplementary Material for: Efficacy of a Self-Directed Video-based Caregiver-Implemented Language Programme

description: Introduction. Caregiver-implemented language programmes are effective for alleviating early language difficulties. This study examined the efficacy of a self-directed video-based caregiver-implement language programme in Chinese families. Method. This study consisted of two stages. In Stage 1, 31 caregiver-child dyads (typically developing children) completed the training programme (Group 1) in the form of six video-based training modules. In Stage 2, 28 caregiver-child dyads (children with language difficulties) receiving active speech therapy were randomly assigned to the training (Group 2) and control arms (Group 3). Group 2 received the same training as Group 1 in addition to their regular therapy while Group 3 was kept as status quo. Caregivers completed a quiz on their knowledge of language facilitation techniques (LFTs) and submitted caregiver-child interaction videos at the start and end of the training. Outcome measures included programme completion rate, quiz scores, and use of LFTs and children’s communication skills in the videos. A pre-post design and a between-group designs were adopted in the Stage 1 and 2 studies respectively. Results. A completion rate of about 60% in both stages was noted. Significantly higher post-training knowledge scores were found in Groups 1 and 2. General but non-significant growth in use of parallel talk and gesture, and significant gains in children’s vocalization in the training arm were observed. Conclusion. The self-directed video-based training programme would be useful in imparting information to caregivers. However, the modest improvements in the use of LFTs suggested direct coaching appeared to still play a significant role in enhancing the actual implementation of LFTs. Further investigation on a larger scale is required to evaluate the effectiveness of the training program for promoting the wider use of this mode as a preventive measure.
DOI: 10.17909/b589-x726
title: IUE data SWP for HD 110073
DOI: 10.25934/00005166
title: Severe sepsis in the cardiac intensive care unit: management strategies and outcomes

description: Patients in the contemporary cardiac intensive care unit (CICU) present with an increasing frequency of non-cardiac critical illness syndromes including severe sepsis (Jentzer et al., 2019; Vallabhajosyula et al., 2019). Cardiac patients with severe sepsis have a higher frequency of conditions that could impact sepsis management including heart failure, valvular disease, arrhythmia, and ischemic heart disease (Bohula et al., 2019; Katz et al., 2016; Morrow et al., 2012). Moreover, cardiac patients with severe sepsis may have sepsis sources that differ from the general population such as infected cardiac implantable devices (Kusumoto et al., 2017) or endocarditis (Cahill et al., 2017). Whether current paradigms and guidelines for sepsis management (Levy, Evans, & Rhodes, 2018) apply to cardiac patients with severe sepsis is not known. 
Therefore, we aim to compare CICU patients with severe sepsis to the general population of severe sepsis patients. We hypothesize that demographics, source of sepsis and management strategies will differ substantially for septic cardiac patients and that outcomes will be worse with high rates of in-hospital mortality. Successful completion of our aims will provide impetus for prospective intervention trials is septic cardiac patients, inform CICU staffing and prognostication, and inform future iterations of sepsis guidelines. To fill these gaps in knowledge, we propose an international retrospective cohort study of patients with severe sepsis enrolled in the PROGRESS registry (Beale et al., 2010; Beale et al., 2009; Martin et al., 2009) of severe sepsis.
DOI: 10.6084/m9.figshare.24242506.v1
title: Supplementary Material for: Efficacy of a Self-Directed Video-based Caregiver-Implemented Language Programme

description: Introduction. Caregiver-implemented language programmes are effective for alleviating early language difficulties. This study examined the efficacy of a self-directed video-based caregiver-implement language programme in Chinese families. Method. This study consisted of two stages. In Stage 1, 31 caregiver-child dyads (typically developing children) completed the training programme (Group 1) in the form of six video-based training modules. In Stage 2, 28 caregiver-child dyads (children with language difficulties) receiving active speech therapy were randomly assigned to the training (Group 2) and control arms (Group 3). Group 2 received the same training as Group 1 in addition to their regular therapy while Group 3 was kept as status quo. Caregivers completed a quiz on their knowledge of language facilitation techniques (LFTs) and submitted caregiver-child interaction videos at the start and end of the training. Outcome measures included programme completion rate, quiz scores, and use of LFTs and children’s communication skills in the videos. A pre-post design and a between-group designs were adopted in the Stage 1 and 2 studies respectively. Results. A completion rate of about 60% in both stages was noted. Significantly higher post-training knowledge scores were found in Groups 1 and 2. General but non-significant growth in use of parallel talk and gesture, and significant gains in children’s vocalization in the training arm were observed. Conclusion. The self-directed video-based training programme would be useful in imparting information to caregivers. However, the modest improvements in the use of LFTs suggested direct coaching appeared to still play a significant role in enhancing the actual implementation of LFTs. Further investigation on a larger scale is required to evaluate the effectiveness of the training program for promoting the wider use of this mode as a preventive measure.
DOI: 10.6084/m9.figshare.24242506
title: Supplementary Material for: Efficacy of a Self-Directed Video-based Caregiver-Implemented Language Programme

description: Introduction. Caregiver-implemented language programmes are effective for alleviating early language difficulties. This study examined the efficacy of a self-directed video-based caregiver-implement language programme in Chinese families. Method. This study consisted of two stages. In Stage 1, 31 caregiver-child dyads (typically developing children) completed the training programme (Group 1) in the form of six video-based training modules. In Stage 2, 28 caregiver-child dyads (children with language difficulties) receiving active speech therapy were randomly assigned to the training (Group 2) and control arms (Group 3). Group 2 received the same training as Group 1 in addition to their regular therapy while Group 3 was kept as status quo. Caregivers completed a quiz on their knowledge of language facilitation techniques (LFTs) and submitted caregiver-child interaction videos at the start and end of the training. Outcome measures included programme completion rate, quiz scores, and use of LFTs and children’s communication skills in the videos. A pre-post design and a between-group designs were adopted in the Stage 1 and 2 studies respectively. Results. A completion rate of about 60% in both stages was noted. Significantly higher post-training knowledge scores were found in Groups 1 and 2. General but non-significant growth in use of parallel talk and gesture, and significant gains in children’s vocalization in the training arm were observed. Conclusion. The self-directed video-based training programme would be useful in imparting information to caregivers. However, the modest improvements in the use of LFTs suggested direct coaching appeared to still play a significant role in enhancing the actual implementation of LFTs. Further investigation on a larger scale is required to evaluate the effectiveness of the training program for promoting the wider use of this mode as a preventive measure.
DOI: 10.6084/m9.figshare.24242533.v1
title: Supplementary Material for: Relationship between the ratio of red cell distribution width to albumin and 28-day mortality among Chinese patients over 80 years with atrial fibrillation

description: Introduction: Atrial fibrillation (AF) is a prevalent heart arrhythmia in elderly adults aged 80 years or older. The red cell distribution width to albumin ratio has been acknowledged as a reliable prognostic marker for poor outcomes in a variety of disorders. However, there exists limited scientific evidence on the association of red cell distribution width to albumin (RAR) with mortality in geriatric individuals with AF. Methods: From January 2015 to June 2020, a retrospective study was conducted in a tertiary academic institution that diagnosed 1141 elderly adults with atrial fibrillation (AF). The RAR value was calculated as the ratio of RDW (%) to albumin (g/dL). The potential association between RAR and cardiovascular mortality and the risk of all-cause mortality within 28 days was evaluated by means of multivariable Cox regression analysis. Results: The 28-day all-cause and cardiovascular mortality rates were 8.7% and 3.3%, respectively. Increased RAR tertiles were found to be significantly associated with greater all-cause mortality (T1: 1.6%; T2: 6.2%; T3: 18.1%, P &lt; 0.001) and cardiovascular mortality (T1: 0.8%; T2: 2.9%; T3: 6.3%, P &lt; 0.001) using Kaplan‒Meier analysis. Continuous RAR had a positive association with all-cause mortality (HR=1.42, 95% CI 1.23-1.65) and cardiovascular mortality (HR=1.31, 95% CI 1.05-1.64), even after accounting for numerous confounding variables. In comparison to the T1 group, individuals with the highest RAR levels displayed a greater risk of all-cause mortality (HR=2.73, 95% CI 1.11-6.74) and cardiovascular mortality (HR=2.59, 95% CI 0.69-9.78). Increased RAR levels were related to higher rates of cardiovascular and all-cause mortality across almost all subgroups. Conclusion: RAR is independently correlated with 28-day all-cause mortality and cardiovascular mortality in AF-affected individuals aged ≥ 80. Keywords: cardiovascular disease; mortality; older; red cell distribution width; atrial fibrillation
DOI: 10.6084/m9.figshare.24242557.v1
title: Supplementary Material for: Effects of exercise during chemo- or radiotherapy on immune markers – a systematic review

description: Introduction Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise was shown to positively influence the immune system in several populations, while exercise overload may have negative effects. Exercise is currently recommended for all patients with cancer. However, knowledge regarding the effects of exercise on immune markers in patients undergoing chemo- or radiotherapy is limited. The aim of this study is to systematically review the effects of moderate and high intensity exercise interventions in patients with cancer during chemotherapy or radiotherapy, on immune markers. Methods For this review, a search was performed in PubMed and EMBASE, until March 2023. Methodological quality was assessed with the Pedro tool and best-evidence syntheses were performed both per immune marker and for the inflammatory profile. Results Methodological quality of the 15 included articles was rated fair to good. The majority of markers was unaltered, but observed effects included a suppressive effect of exercise during radiotherapy on some pro-inflammatory markers, a preserving effect of exercise during chemotherapy on NK cell degranulation and cytotoxicity, a protective effect on the decrease in thrombocytes during chemotherapy, and a positive effect of exercise during chemotherapy on IgA. Discussion/conclusion Although exercise only influenced a few markers, the results are promising. Exercise did not negatively influence immune markers, and some were positively affected since suppressed inflammation might have positive clinical implications. For future research, consensus is needed regarding a set of markers that are most responsive to exercise. Next, differential effects of training types and intensities on these markers should be further investigated, as well as their clinical implications.
DOI: 10.5281/zenodo.8115152
title: Data set "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra"

description: README This data set accompanies the publication "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra"<br> by Julia Brüggemann, Maria Chekmeneva, Mario Wolter, and Christoph R. Jacob<br> (TU Braunschweig, Germany) It contains the following files: <br> Directory 01_structures: - xyz files of all considered molecular structures.
DOI: 10.5281/zenodo.8115151
title: Data set "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra"

description: This data set accompanies the publication "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra" by Julia Brüggemann, Maria Chekmeneva, Mario Wolter, and Christoph R. Jacob (TU Braunschweig, Germany) It contains the following files: Directory 01_structures: - xyz files of all considered molecular structures. Directory 02_2d-ir_data_and_code: - updated version of the code of calculating 2D-IR spectra, initially published in DOI: 10.5281/zenodo.7328312, which can be used to obtain the 2D-IR spectra shown in the publication and its supporting information.
DOI: 10.5281/zenodo.8364410
title: Data set "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra"

description: README This data set accompanies the publication "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra"<br> by Julia Brüggemann, Maria Chekmeneva, Mario Wolter, and Christoph R. Jacob<br> (TU Braunschweig, Germany) It contains the following files: <br> Directory 01_structures: - xyz files of all considered molecular structures.
DOI: 10.5281/zenodo.8406331
title: Data set "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra"

description: This data set accompanies the publication "Structural Dependence of Extended Amide III Vibrations in Two-Dimensional Infrared Spectra" by Julia Brüggemann, Maria Chekmeneva, Mario Wolter, and Christoph R. Jacob (TU Braunschweig, Germany) It contains the following files: Directory 01_structures: - xyz files of all considered molecular structures. Directory 02_2d-ir_data_and_code: - updated version of the code of calculating 2D-IR spectra, initially published in DOI: 10.5281/zenodo.7328312, which can be used to obtain the 2D-IR spectra shown in the publication and its supporting information.