cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21515115
title: Additional file 5 of Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

description: Additional file 5: Supplementary Figure 1. Leave-one-out permutation analysis plot for AD signature among individuals at high genetic predisposition to AD obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 2. Leave-one-out permutation analysis plot for Aging signature among individuals at high genetic predisposition to AD, obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 3. Leave-one-out permutation analysis plot for Aβ ratio among APOE-ɛ4 non-carriers obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 4. Leave-one-out permutation analysis plot for NfL among APOE-ɛ4 non-carriers obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 5. Leave-one-out permutation analysis plot for p-tau among individuals at high genetic predisposition to AD, obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables.
DOI: 10.6084/m9.figshare.16780901.v1
title: Additional file 9 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

description: Additional file 9:. FastQTL meQTL mapping results for RV-treated AECs (FDR&lt; 0.05).
DOI: 10.6084/m9.figshare.21515116
title: Additional file 2 of A genome-wide association study of mammographic texture variation

description: Additional file 2: Table S1. Number of GWAS subjects by study and platform. Table S4. GWAS results of significant V loci for all V assessments and models. Table S5. Lookup results of 72 MD phenotype SNPs in GWAS of V. Table S6. Lookup results of 195 breast cancer SNPs in GWAS of V. Table S7. Genetic correlation results of all V assessments and models. Table S8. SNP-set test results of all V assessments and models.
DOI: 10.6084/m9.figshare.21515116.v1
title: Additional file 2 of A genome-wide association study of mammographic texture variation

description: Additional file 2: Table S1. Number of GWAS subjects by study and platform. Table S4. GWAS results of significant V loci for all V assessments and models. Table S5. Lookup results of 72 MD phenotype SNPs in GWAS of V. Table S6. Lookup results of 195 breast cancer SNPs in GWAS of V. Table S7. Genetic correlation results of all V assessments and models. Table S8. SNP-set test results of all V assessments and models.
DOI: 10.6084/m9.figshare.6834860.v5
title: Covariate-Adjusted Tensor Classification in High Dimensions

description: In contemporary scientific research, it is often of great interest to predict a categorical response based on a high-dimensional tensor (i.e., multi-dimensional array) and additional covariates. Motivated by applications in science and engineering, we propose a comprehensive and interpretable discriminant analysis model, called the CATCH model (short for covariate-adjusted tensor classification in high-dimensions). The CATCH model efficiently integrates the covariates and the tensor to predict the categorical outcome. It also jointly explains the complicated relationships among the covariates, the tensor predictor, and the categorical response. The tensor structure is used to achieve easy interpretation and accurate prediction. To tackle the new computational and statistical challenges arising from the intimidating tensor dimensions, we propose a penalized approach to select a subset of the tensor predictor entries that affect classification after adjustment for the covariates. An efficient algorithm is developed to take advantage of the tensor structure in the penalized estimation. Theoretical results confirm that the proposed method achieves variable selection and prediction consistency, even when the tensor dimension is much larger than the sample size. The superior performance of our method over existing methods is demonstrated in extensive simulated and real data examples. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.12601652.v1
title: Newly designed and synthesized heterobimetallic [Cu<sup>II</sup>–Dy<sup>III</sup>] salamo-like complex: structural characterization, DFT calculation, and fluorescent property

description: A heterobimetallic 3d–4f complex [Cu(L)Dy(NO<sub>3</sub>)<sub>3</sub>] based on a symmetric salamo-like ligand (H<sub>2</sub>L) was synthesized and characterized by elemental analyses, IR, UV-Vis spectroscopy, and single-crystal X-ray diffraction. The complex crystallized in the monoclinic, space group P 2<sub>1</sub>/c, included one tetra-coordinated Cu(II) atom (Cu1), one deca-coordinated Dy(III) atom (Dy1), one completely deprotonated (L)<sup>2−</sup> unit, and three nitrate groups involved in coordination. Cu1 adopted a planar quadrilateral configuration, and Dy1 formed a slightly distorted double-cap square antiprism geometry. The complex finally formed an infinite 2D and 3D supramolecular structure via the intermolecular hydrogen bonds and π–π interactions. Due to the paramagnetism of Cu<sup>2+</sup> ions, the complex showed fluorescence quenching. The electronic structure and stability of the complex were proved by density functional theory (DFT) calculation.
DOI: 10.6084/m9.figshare.4737727
title: Collaborative approach of individual participant data of prospective studies of de-escalation in non-immunosuppressed critically ill patients with sepsis

description: <b>Background</b>: There is a concern to conduct de-escalation in very sick patients. <b>Aims</b>: To determine if de-escalation is feasible in ICU settings. <b>Methods</b>: We performed a metaanalysis of published studies conducted comparing de-escalation (defined by withdrawal of at least one antimicrobial empirically prescribed, switch to a new antimicrobial with narrower spectrum and withdrawal of at least one antimicrobial plus change of another drug to a new one with narrower spectrum) in non-immunocompromised patients with sepsis admitted to ICU. <b>Results</b>: Eight hundred and seventeen patients with severe sepsis or septic shock were evaluated. De-escalation was applied in 274 patients (33.5%). We found no differences in hospital long of stay between de-escalation group compared to those who did not receive it. We also found significant lower hospital mortality in de-escalation group as compared with no modification group in front of the others (25.9 vs. 43.1%; p &lt; 0.001). Taking into account the etiology of infection, in both gram negative and gram positives microorganisms, de-escalation strategy was assessed as a good prognosis factor for mortality in the adjusted multivariate analysis (OR 0.41; 95% CI 0.22–0.74 and OR 0.33; 95% CI 0.15–0.70 respectively) whereas SOFA score along with age were found as a factors independently associated with a worse clinical outcome (OR 1.23; 95% CI 1.12–1.35 and OR 1.02; 95% CI 1.01–1.04 respectively). <b>Conclusions</b>: In our study there was an independent association of de-escalation and decrease mortality rate.
DOI: 10.6084/m9.figshare.12599346
title: Additional file 3 of Transcriptome analyses revealed the ultraviolet B irradiation and phytohormone gibberellins coordinately promoted the accumulation of artemisinin in Artemisia annua L.

description: Additional file 3: Table S2. Expression value (FPKM) of the 250 differentially expressed genes (DEGs) in response to both GA, UV, and GA+UV treatments in artemisia and their predicted function (162 up-regulation DEGs genes, 88 down-regulation DEGs genes). CK = control group, GA = gibberellin, UV = ultra-violet-B irradiation, GA+UV = combination of gibberellin and ultra-violet-B irradiation.
DOI: 10.6084/m9.figshare.16780898
title: Additional file 8 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

description: Additional file 8:. FastQTL meQTL mapping results for vehicle-treated AECs (FDR&lt; 0.05).
DOI: 10.6084/m9.figshare.2117140
title: Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields

description: The increasing prevalence of extremely low frequency electromagnetic fields (ELF-EMFs) exposure has raised considerable public concern regarding the potential hazardous effects of ELF-EMFs on male reproductive function. Increasing evidence indicates that miRNAs are necessary for spermatogenesis and male fertility. However, the regulation of miRNA expression and the roles of miRNAs in response to ELF-EMFs remain unclear. In our study, mouse spermatocyte-derived GC-2 cells were intermittently exposed to a 50 Hz ELF-EMF for 72 h (5 min on/10 min off) at magnetic field intensities of 1 mT, 2 mT and 3 mT. MiR-26b-5p was differentially expressed in response to different magnetic field intensities of ELF-EMFs. The host gene CTDSP1 showed an unmethylation status in GC-2 cells at different magnetic field intensities of ELF-EMF exposure. MiR-26b-5p had no significant, obvious influence on the cell viability, apoptosis or cell cycle of GC-2 cells. However, the overexpression of miR-26b-5p significantly decreased the percentage of G0/G1 phase cells and slightly increased the percentage of S phase cells compared to the sham group that was exposed to a 50 Hz ELF-EMF. Computational algorithms identified Cyclin D2 (CCND2) as a direct target of miR-26b-5p. MiR-26b-5p and a 50 Hz ELF-EMF altered the expression of CCND2 at both the mRNA and protein levels. Overexpressed miR-26b-5p in GC-2 cells can change the mRNA expression of CCND2 following 50 Hz ELF-EMF at 3 mT. These findings demonstrate that miR-26b-5p could serve as a potential biomarker following 50 Hz ELF-EMF exposure, and miR-26b-5p-CCND2-mediated cell cycle regulation might play a pivotal role in the biological effects of ELF-EMFs.
DOI: 10.6084/m9.figshare.2117140.v1
title: Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields

description: The increasing prevalence of extremely low frequency electromagnetic fields (ELF-EMFs) exposure has raised considerable public concern regarding the potential hazardous effects of ELF-EMFs on male reproductive function. Increasing evidence indicates that miRNAs are necessary for spermatogenesis and male fertility. However, the regulation of miRNA expression and the roles of miRNAs in response to ELF-EMFs remain unclear. In our study, mouse spermatocyte-derived GC-2 cells were intermittently exposed to a 50 Hz ELF-EMF for 72 h (5 min on/10 min off) at magnetic field intensities of 1 mT, 2 mT and 3 mT. MiR-26b-5p was differentially expressed in response to different magnetic field intensities of ELF-EMFs. The host gene CTDSP1 showed an unmethylation status in GC-2 cells at different magnetic field intensities of ELF-EMF exposure. MiR-26b-5p had no significant, obvious influence on the cell viability, apoptosis or cell cycle of GC-2 cells. However, the overexpression of miR-26b-5p significantly decreased the percentage of G0/G1 phase cells and slightly increased the percentage of S phase cells compared to the sham group that was exposed to a 50 Hz ELF-EMF. Computational algorithms identified Cyclin D2 (CCND2) as a direct target of miR-26b-5p. MiR-26b-5p and a 50 Hz ELF-EMF altered the expression of CCND2 at both the mRNA and protein levels. Overexpressed miR-26b-5p in GC-2 cells can change the mRNA expression of CCND2 following 50 Hz ELF-EMF at 3 mT. These findings demonstrate that miR-26b-5p could serve as a potential biomarker following 50 Hz ELF-EMF exposure, and miR-26b-5p-CCND2-mediated cell cycle regulation might play a pivotal role in the biological effects of ELF-EMFs.
DOI: 10.6084/m9.figshare.7884308
title: Additional file 6: of RNA-Seq analysis reveals transcript diversity and active genes after common cutworm (Spodoptera litura Fabricius) attack in resistant and susceptible wild soybean lines

description: Table S6. DEGs in the resistant accession W99 at 3 d. (XLSX 341 kb)
DOI: 10.6084/m9.figshare.7884365
title: MOESM4 of Kluyveromyces marxianus developing ethanol tolerance during adaptive evolution with significant improvements of multiple pathways

description: Additional file 4. Genes involved in pathways closely related to ethanol tolerance. A file containing the referred pathways in this study, as well as the involved DE genes.
DOI: 10.6084/m9.figshare.7884365.v1
title: MOESM4 of Kluyveromyces marxianus developing ethanol tolerance during adaptive evolution with significant improvements of multiple pathways

description: Additional file 4. Genes involved in pathways closely related to ethanol tolerance. A file containing the referred pathways in this study, as well as the involved DE genes.
DOI: 10.6084/m9.figshare.12599340
title: Additional file 1 of Transcriptome analyses revealed the ultraviolet B irradiation and phytohormone gibberellins coordinately promoted the accumulation of artemisinin in Artemisia annua L.

description: Additional file 1: Table S1. List of the primers used for qRT-PCR experiments in Artemisia annul.
DOI: 10.6084/m9.figshare.13126437
title: Additional file 2 of Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

description: Additional file 2:. EMBASE search strategy (XLS 19 kb)
DOI: 10.6084/m9.figshare.13126437.v1
title: Additional file 2 of Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

description: Additional file 2:. EMBASE search strategy (XLS 19 kb)
DOI: 10.6084/m9.figshare.22040357
title: Physicochemical and antioxidant properties of extruded Rhodiola as affected by twin-screw extrusion

description: In order to explore the effect of extrusion operating parameters on the physicochemical and antioxidation properties of the extruded Rhodiola, Rhodiola was extruded as raw material under different moisture content (24, 26, 28%), barrel temperature (120, 130, 140°C) and screw speed (200, 250, 300 rpm) conditions. After extrusion, the water solubility index of Rhodiola was significantly higher than that of raw material, while the water absorption index was significantly lower than that of raw material. In addition, due to Maillard reaction, L* and a* values of color decreased significantly. The extraction rate of soluble substances, rhodioloside, total flavonoids and total phenols of <i>Rhodiola rosea</i> after extrusion were significantly higher (<i>P &lt; .05</i>) than those of the raw material. Both moisture content and barrel temperature had important effects on the total phenolic content and antioxidant activity. At the same time, moisture content also significantly affected the rhodioloside content when the barrel temperature significantly affected the total flavonoid content. Whereas, the screw speed significantly affected the total flavonoid content. In conclusion, the extrusion process facilitated the increase of active ingredients of Rhodiola and significantly enhanced its antioxidant capacity.
DOI: 10.6084/m9.figshare.22040357.v1
title: Physicochemical and antioxidant properties of extruded Rhodiola as affected by twin-screw extrusion

description: In order to explore the effect of extrusion operating parameters on the physicochemical and antioxidation properties of the extruded Rhodiola, Rhodiola was extruded as raw material under different moisture content (24, 26, 28%), barrel temperature (120, 130, 140°C) and screw speed (200, 250, 300 rpm) conditions. After extrusion, the water solubility index of Rhodiola was significantly higher than that of raw material, while the water absorption index was significantly lower than that of raw material. In addition, due to Maillard reaction, L* and a* values of color decreased significantly. The extraction rate of soluble substances, rhodioloside, total flavonoids and total phenols of <i>Rhodiola rosea</i> after extrusion were significantly higher (<i>P &lt; .05</i>) than those of the raw material. Both moisture content and barrel temperature had important effects on the total phenolic content and antioxidant activity. At the same time, moisture content also significantly affected the rhodioloside content when the barrel temperature significantly affected the total flavonoid content. Whereas, the screw speed significantly affected the total flavonoid content. In conclusion, the extrusion process facilitated the increase of active ingredients of Rhodiola and significantly enhanced its antioxidant capacity.
DOI: 10.6084/m9.figshare.13126440
title: Additional file 3 of Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

description: Additional file 3:. Cochrane search strategy
DOI: 10.6084/m9.figshare.21515083
title: Additional file 2 of A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes

description: Additional file 2: Supplementary Table 1. TOGA status of 18430 ancestral placental mammal genes in muroid rodent genome assemblies. Supplementary Table 2. Positively selected genes and their mutation tolerance in humans according to gnomAD.
DOI: 10.6084/m9.figshare.21515103
title: Additional file 1 of Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

description: Additional file 1: Supplementary Table 1. Characteristics of Single Nucleotide Polymorphisms (SNPs) associated with longer telomere length. The effect allele refers to the allele that is associated with longer telomere length. Chromosomal position of the SNPs (genome assembly GRCh37 (hg19)) according to the public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the National Human Genome Research Institute (NHGRI) (dbSNP).
DOI: 10.6084/m9.figshare.7359311
title: Time-resolved fluorescent immunochromatographic assay-based on three antibody labels for the simultaneous detection of aflatoxin B<sub>1</sub> and zearalenone in Chinese herbal medicines

description: A time-resolved fluorescent immunochromatographic assay (TRFICA) was successfully developed for the sensitive, simultaneous, and quantitative detection of aflatoxin B<sub>1</sub> (AFB1) and zearalenone (ZEN) in Chinese herbal medicines. Eu-nanospheres (EuNPs) with unique optical properties increased the stability and sensitivity of the immunochromatographic assay. To obtain stable quantitative results, we applied a three-label system in which monoclonal antibodies for AFB1 and ZEN were conjugated to the EuNPs as detection probes on the test line (T line), and EuNP-labelled chicken IgY conjugates acted as the reference on the control line (C line). The fluorescence intensities of the T and C lines were recorded, and the T/C ratio was employed as the quantitative signal for the elimination of strip variation and matrix effects. The parameters that affected the TRFICA were optimised. Under optimal conditions, the established TRFICA gave good linear ranges from 0.60 μg/kg to 3.92 μg/kg for AFB1 and from 0.40 μg/kg to 1.28 μg/kg for ZEN. The limits of detection for AFB1 and ZEN were as low as 0.60 and 0.40 μg/kg, respectively, in Chinese herbal medicines <i>Semen coicis, Rhizoma dioscoreae</i>, and <i>Platycodon grandiflorus</i>, respectively. The average recoveries of the spiked samples were 73%–95% for AFB1 and 75.83%–90% for ZEN, both with a relative standard deviation of &lt; 9.08%. The results of 15 actual samples detected by the developed TRFICA showed a satisfactory correlation with those of ultra-performance liquid chromatography tandem mass spectrometry. Therefore, the TRFICA is a simple, rapid, and sensitive approach to quantitatively detect mycotoxins in Chinese herbal medicines.
DOI: 10.6084/m9.figshare.12599355.v1
title: Additional file 6 of Transcriptome analyses revealed the ultraviolet B irradiation and phytohormone gibberellins coordinately promoted the accumulation of artemisinin in Artemisia annua L.

description: Additional file 6: Table S4. Repartition of the artemisinin-related genes after different treatments into the six co-expressed modules (Blue, Green, Brown, Yellow, Turquoise and Grey) detected by WGCNA.
DOI: 10.6084/m9.figshare.14699488
title: The efficacy of platelet rich plasma on anterior cruciate ligament reconstruction: a systematic review and meta-analysis

description: Anterior cruciate ligament (ACL) rupture is a common musculoskeletal injury, most frequently affecting young and physically active patients. Platelet-rich plasma (PRP) has been widely used in ACL reconstruction to augment the graft healing. However, high-level studies addressing its clinical efficacy could not reach a consensus. In this study, we assess the efficacy of PRP on pain relief, functional improvement along with radiological changes in patients who underwent ACL reconstruction. We performed comprehensive literature search and included 17 RCTs containing 970 participants who underwent ACL reconstruction. The combined data showed significant difference between PRP and control with regard to VAS score (MD: −1.12, 95% CI −1.92, −0.31; <i>P</i> = .007), subjective IKDC score (MD: 6.08, 95% CI 4.39, 7.77; <i>P</i> &lt; .00001) and Lysholm score (MD: 8.49, 95% CI 1.63, 15.36; <i>P</i> = .02) by postoperative 6 months, but only pain reduction was deemed clinically important. At the end of one year’s follow-up, no clinically meaningful improvement in VAS (MD: −0.47, <i>P</i> = .04), subjective IKDC score (MD: 3.99, <i>P</i> = .03), Lysholm score (MD: 2.30, <i>P</i> = .32), objective IKDC score (RR: 1.03, <i>P</i> = .09) and knee joint laxity (MD: 0.17, <i>P</i> = .28) was seen. In terms of radiological findings, about one-third of the studies favored PRP to facilitate the graft healing, improve the harvest site morbidity and prevent tunnel widening. In summary, moderate quality of evidence suggested that PRP could provide short-term but not long-term clinically important pain reduction.