cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30246601
title: Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis

description: We compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups. We used whole-blood methylome profiles for 5,146 ALS patients and 2,156 controls available for Project MinE. We predicted biological age with three generations of epigenetic clocks and estimated age acceleration by regressing our model on control individuals to evaluate case/control differences. To investigate the contribution of <i>C9orf72</i> expansions, we regressed the model on <i>C9orf72</i>-negative ALS patients. The predicted DunedinPACE pace of aging and telomere length additionally characterized aging dynamics. We found that white blood cell type proportions confound the previously observed increase in the pace of biological aging in ALS. When correcting for cell counts, there is no evidence for accelerated epigenetic aging compared to controls, except for ALS patients with the <i>C9orf72</i> repeat expansion. None of the epigenetic age acceleration scores contributed to survival. Our study revealed no significant difference in the pace of biological agingbetween ALS patients and controls, except for ALS patients carrying the <i>C9orf72</i> mutation. We emphasize the importance of altered white blood cell proportions in general ALS pathophysiology as opposed to accelerated aging per se. Amyotrophic Lateral Sclerosis (ALS) is a serious disease that affects the nervous system and makes it hard for people to move. One of the main risk factors for developing ALS is getting older. Our study looked at whether people with ALS have signs of aging faster than those who don’t have the disease. To do so, we examined changes in chemical markers on DNA, called DNA methylation, that occur as people age. We studied blood samples from 5,146 ALS patients and 2,156 healthy individuals, using several tools that estimate biological age and how quickly it changes. Our results showed that differences in immune cell composition help explain why it seems like ALS patients age faster. After taking these differences into account, we found that, generally, ALS patients did not age faster than healthy controls. However, those with the <i>C9orf72</i> genetic mutation did show signs of aging more quickly. Overall, our findings suggest that changes in immune cells are very important in ALS and may be more significant than the idea of accelerated aging, except for patients with the <i>C9orf72</i> mutation.
DOI: 10.6084/m9.figshare.30246601.v1
title: Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis

description: We compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups. We used whole-blood methylome profiles for 5,146 ALS patients and 2,156 controls available for Project MinE. We predicted biological age with three generations of epigenetic clocks and estimated age acceleration by regressing our model on control individuals to evaluate case/control differences. To investigate the contribution of <i>C9orf72</i> expansions, we regressed the model on <i>C9orf72</i>-negative ALS patients. The predicted DunedinPACE pace of aging and telomere length additionally characterized aging dynamics. We found that white blood cell type proportions confound the previously observed increase in the pace of biological aging in ALS. When correcting for cell counts, there is no evidence for accelerated epigenetic aging compared to controls, except for ALS patients with the <i>C9orf72</i> repeat expansion. None of the epigenetic age acceleration scores contributed to survival. Our study revealed no significant difference in the pace of biological agingbetween ALS patients and controls, except for ALS patients carrying the <i>C9orf72</i> mutation. We emphasize the importance of altered white blood cell proportions in general ALS pathophysiology as opposed to accelerated aging per se. Amyotrophic Lateral Sclerosis (ALS) is a serious disease that affects the nervous system and makes it hard for people to move. One of the main risk factors for developing ALS is getting older. Our study looked at whether people with ALS have signs of aging faster than those who don’t have the disease. To do so, we examined changes in chemical markers on DNA, called DNA methylation, that occur as people age. We studied blood samples from 5,146 ALS patients and 2,156 healthy individuals, using several tools that estimate biological age and how quickly it changes. Our results showed that differences in immune cell composition help explain why it seems like ALS patients age faster. After taking these differences into account, we found that, generally, ALS patients did not age faster than healthy controls. However, those with the <i>C9orf72</i> genetic mutation did show signs of aging more quickly. Overall, our findings suggest that changes in immune cells are very important in ALS and may be more significant than the idea of accelerated aging, except for patients with the <i>C9orf72</i> mutation.
DOI: 10.57903/uj/tyoxdi
title: MCPIP3 orchestrates the balance of epidermal proliferation and differentiation - raw research data

description: Dataset of raw data related to the publication doi: 10.1186/s12964-025-02184-1.
DOI: 10.48366/r1557928
title: Multi-modal language learning

description: Six research papers investigate multi-modal language learning in Artificial intelligence and Robot-Assisted domains.
DOI: 10.15468/dl.8xs9dx
title: Occurrence Download

description: A dataset listing the 185 species recorded in GBIF matching the query:
{
 "and" : [
 "GadmGid is ITA.6.7.7_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Aves"
 ]
}

 The dataset's 185 records were derived from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0054872-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17376169
title: Datasets used in the article "Efficient ice multiplication from freezing raindrop fragmentation"
DOI: 10.5281/zenodo.17434700
title: Datasets used in the article "Efficient ice multiplication from freezing raindrop fragmentation"
DOI: 10.5517/ccdc.csd.cc1mxrjt
title: CCDC 1517187: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrkv
title: CCDC 1517188: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrlw
title: CCDC 1517189: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrmx
title: CCDC 1517190: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrny
title: CCDC 1517191: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrpz
title: CCDC 1517192: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrq0
title: CCDC 1517193: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrr1
title: CCDC 1517194: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpmrp
title: CCDC 1510343: Experimental Crystal Structure Determination

description: Related Article: Benjamin M. Kriegel,  Lara C. E. Naested,  Grégory Nocton,  K. V. Lakshmi,  Trevor D. Lohrey,  Robert G. Bergman,  and John Arnold|2017|Inorg.Chem.|56|1626|doi:10.1021/acs.inorgchem.6b02735
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mxrs2
title: CCDC 1517195: Experimental Crystal Structure Determination

description: Related Article: Cristiana Cesari,  Iacopo Ciabatti,  Cristina Femoni,  Maria Carmela Iapalucci,  Federica Mancini,  and Stefano Zacchini|2017|Inorg.Chem.|56|1655|doi:10.1021/acs.inorgchem.6b02750
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpmsq
title: CCDC 1510344: Experimental Crystal Structure Determination

description: Related Article: Benjamin M. Kriegel,  Lara C. E. Naested,  Grégory Nocton,  K. V. Lakshmi,  Trevor D. Lohrey,  Robert G. Bergman,  and John Arnold|2017|Inorg.Chem.|56|1626|doi:10.1021/acs.inorgchem.6b02735
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpmvs
title: CCDC 1510346: Experimental Crystal Structure Determination

description: Related Article: Benjamin M. Kriegel,  Lara C. E. Naested,  Grégory Nocton,  K. V. Lakshmi,  Trevor D. Lohrey,  Robert G. Bergman,  and John Arnold|2017|Inorg.Chem.|56|1626|doi:10.1021/acs.inorgchem.6b02735
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpmwt
title: CCDC 1510347: Experimental Crystal Structure Determination

description: Related Article: Benjamin M. Kriegel,  Lara C. E. Naested,  Grégory Nocton,  K. V. Lakshmi,  Trevor D. Lohrey,  Robert G. Bergman,  and John Arnold|2017|Inorg.Chem.|56|1626|doi:10.1021/acs.inorgchem.6b02735
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpmtr
title: CCDC 1510345: Experimental Crystal Structure Determination

description: Related Article: Benjamin M. Kriegel,  Lara C. E. Naested,  Grégory Nocton,  K. V. Lakshmi,  Trevor D. Lohrey,  Robert G. Bergman,  and John Arnold|2017|Inorg.Chem.|56|1626|doi:10.1021/acs.inorgchem.6b02735
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1nqtpw
title: CCDC 1541279: Experimental Crystal Structure Determination

description: Related Article: Benita Barton, Sasha-Lee Dorfling, Eric C. Hosten|2017|Cryst.Growth Des.|17|6725|doi:10.1021/acs.cgd.7b01334
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpc3s
title: CCDC 1510075: Experimental Crystal Structure Determination

description: Related Article: Nasrina Parvin, Shiv Pal, Shabana Khan, Shubhajit Das, Swapan K. Pati, and Herbert W. Roesky|2017|Inorg.Chem.|56|1706|doi:10.1021/acs.inorgchem.6b02833
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpc4t
title: CCDC 1510076: Experimental Crystal Structure Determination

description: Related Article: Nasrina Parvin, Shiv Pal, Shabana Khan, Shubhajit Das, Swapan K. Pati, and Herbert W. Roesky|2017|Inorg.Chem.|56|1706|doi:10.1021/acs.inorgchem.6b02833
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpc5v
title: CCDC 1510077: Experimental Crystal Structure Determination

description: Related Article: Nasrina Parvin, Shiv Pal, Shabana Khan, Shubhajit Das, Swapan K. Pati, and Herbert W. Roesky|2017|Inorg.Chem.|56|1706|doi:10.1021/acs.inorgchem.6b02833
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpc6w
title: CCDC 1510078: Experimental Crystal Structure Determination

description: Related Article: Nasrina Parvin, Shiv Pal, Shabana Khan, Shubhajit Das, Swapan K. Pati, and Herbert W. Roesky|2017|Inorg.Chem.|56|1706|doi:10.1021/acs.inorgchem.6b02833
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpc7x
title: CCDC 1510079: Experimental Crystal Structure Determination

description: Related Article: Nasrina Parvin, Shiv Pal, Shabana Khan, Shubhajit Das, Swapan K. Pati, and Herbert W. Roesky|2017|Inorg.Chem.|56|1706|doi:10.1021/acs.inorgchem.6b02833
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1mpc8y
title: CCDC 1510080: Experimental Crystal Structure Determination

description: Related Article: Nasrina Parvin, Shiv Pal, Shabana Khan, Shubhajit Das, Swapan K. Pati, and Herbert W. Roesky|2017|Inorg.Chem.|56|1706|doi:10.1021/acs.inorgchem.6b02833
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1md92d
title: CCDC 1501363: Experimental Crystal Structure Determination

description: Related Article: Dhrubajyoti Majumdar, M. S. Surendra Babu, Sourav Das, Chandrajeet Mohapatra, Jayanta Kumar Biswas, Monojit Mondal|2017|Chem. Sel.|2|4811|doi:10.1002/slct.201700743
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1nqtqx
title: CCDC 1541280: Experimental Crystal Structure Determination

description: Related Article: Bartłomiej Pigulski, Jakub Cichos, Sławomir Szafert|2017|ACS Sustain.Chem.Eng.|5|7077|doi:10.1021/acssuschemeng.7b01274
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1nqv18
title: CCDC 1541290: Experimental Crystal Structure Determination

description: Related Article: Michael Trose, Fady Nahra, Albert Poater, David B. Cordes, Alexandra M. Z. Slawin, Luigi Cavallo, and Catherine S. J. Cazin|2017|ACS Catalysis|7|8176|doi:10.1021/acscatal.7b02737
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1nqv29
title: CCDC 1541291: Experimental Crystal Structure Determination

description: Related Article: Michael Trose, Fady Nahra, Albert Poater, David B. Cordes, Alexandra M. Z. Slawin, Luigi Cavallo, and Catherine S. J. Cazin|2017|ACS Catalysis|7|8176|doi:10.1021/acscatal.7b02737
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1nqv3b
title: CCDC 1541292: Experimental Crystal Structure Determination

description: Related Article: Michael Trose, Fady Nahra, Albert Poater, David B. Cordes, Alexandra M. Z. Slawin, Luigi Cavallo, and Catherine S. J. Cazin|2017|ACS Catalysis|7|8176|doi:10.1021/acscatal.7b02737
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.