cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23850660.v1
title: Low-no-calorie sweeteners exert marked compound-specific impact on the human gut microbiota <i>ex vivo</i>

description: Low-no-calorie sweeteners (LNCS) are used as sugar substitutes as part of strategies to reduce the risk of chronic diseases related to high sugar intake (e.g. type 2 diabetes (T2D)). This study investigated how a range of sweeteners [tagatose (TA)/maltitol (MA)/sorbitol (SO)/stevia (ST)/sucralose (SU)/acesulfame K (ACK)] impact the gut microbiota of T2D subjects and healthy human adults using the <i>ex vivo</i> SIFR® technology (<i>n</i> = 12). The cohort covered clinically relevant interpersonal and T2D-related differences. ACK/SU remained intact while not impacting microbial composition and metabolite production. In contrast, TA/SO and ST/MA were respectively readily and gradually fermented. ST and particularly TA/SO/MA increased bacterial density and SCFA production product-specifically: SO increased acetate (∼<i>Bifidobacterium adolescentis</i>), whilst MA/ST increased propionate (∼<i>Parabacteroides distasonis</i>). TA exerted low specificity as it increased butyrate for healthy subjects, yet propionate for T2D subjects. Overall, LNCS exerted highly compound-specific effects stressing that results obtained for one LNCS cannot be generalised to other LNCS.
DOI: 10.25403/upresearchdata.24421498
title: Exploring the relationship between person–environment fit, innovative work behavior, and subjective career success in the contemporary workplace

description: The data was collected by means of an electronic survey administered on the Qualtrics platform. The sample was obtained through non-probability sampling methods, specifically purposive and snowball sampling (<i>n = 492</i>). The first section of the survey required participants to report important biographical information such as their age, gender, race, home language, highest qualification, years of working experience and managerial level. Depending on the question, the participants were required to complete this section in the format of either nominal or ordinal scales. The researcher then used the multidimensional Subjective Career Success Inventory (SCSI) to measure subjective career success. This instrument comprises an eight-factor model, including the factors recognition, quality work, meaningful work, influence, authenticity, personal life, growth and development, and satisfaction. The instrument consisted of 24 items, i.e. each subscale contained three items. The participants were required to indicate the degree to which they agreed/disagreed with each item. The ratings ranged between 1 (strongly disagree) and 5 (strongly agree)The researcher also used the Perceived Fit Scale (PFS) to measure person–environment fit. The scale comprised three factors: person–organisation fit, needs–supplies fit and demands–abilities fit. This instrument consisted of nine items, with each subscale containing three items. Participants were required to indicate the degree to which they agreed/disagreed with each item using a five-point Likert scale. The ratings ranged between 1 (strongly disagree) and 5 (strongly agree).To measure innovative work behaviour in this study, the researcher used the Innovative Work Behaviour Self-report. Participants were required to indicate the frequency with which they were required to conduct each item in their workplace. The ratings ranged between 1 (never) and 7 (always).
DOI: 10.25403/upresearchdata.24421498.v1
title: Exploring the relationship between person–environment fit, innovative work behavior, and subjective career success in the contemporary workplace

description: The data was collected by means of an electronic survey administered on the Qualtrics platform. The sample was obtained through non-probability sampling methods, specifically purposive and snowball sampling (<i>n = 492</i>). The first section of the survey required participants to report important biographical information such as their age, gender, race, home language, highest qualification, years of working experience and managerial level. Depending on the question, the participants were required to complete this section in the format of either nominal or ordinal scales. The researcher then used the multidimensional Subjective Career Success Inventory (SCSI) to measure subjective career success. This instrument comprises an eight-factor model, including the factors recognition, quality work, meaningful work, influence, authenticity, personal life, growth and development, and satisfaction. The instrument consisted of 24 items, i.e. each subscale contained three items. The participants were required to indicate the degree to which they agreed/disagreed with each item. The ratings ranged between 1 (strongly disagree) and 5 (strongly agree)The researcher also used the Perceived Fit Scale (PFS) to measure person–environment fit. The scale comprised three factors: person–organisation fit, needs–supplies fit and demands–abilities fit. This instrument consisted of nine items, with each subscale containing three items. Participants were required to indicate the degree to which they agreed/disagreed with each item using a five-point Likert scale. The ratings ranged between 1 (strongly disagree) and 5 (strongly agree).To measure innovative work behaviour in this study, the researcher used the Innovative Work Behaviour Self-report. Participants were required to indicate the frequency with which they were required to conduct each item in their workplace. The ratings ranged between 1 (never) and 7 (always).
DOI: 10.6084/m9.figshare.24551092
title: Supplementary Material for: Daptomycin-induced eosinophilic pneumonia: a case report and systematic review.

description: Introduction Acute eosinophilic pneumonia (AEP) is a rare respiratory condition caused by eosinophil accumulation in the pulmonary tissue that can be related to drug administration. Daptomycin, an antibiotic active against gram-positive bacteria, is one of the leading causes of AEP among drugs. In order to raise awareness of this rare syndrome, in our work we have described a case of an 82 years-old male with Enterococcus faecalis endocarditis treated with daptomycin, who developed a daptomycin-induced AEP. We have performed a systematic review of the literature for all similar reported cases. Methods The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. To conduct the analysis, the terms “daptomycin AND eosinoph* AND pneum*”, were entered the databases Medline, Cinahl and Embase on April 13th, 2023. We considered relevant all records documenting AEP after daptomycin use. No restrictions in terms of year or language were made. A formal appraisal of observational studies was performed by Newcastle-Ottawa Scale. All results and data were reported by means of tables. Results Our search identified 93 relevant records, published between 2007 and 2023. A total of 120 patients were considered. Patients who experienced AEP were mostly males (n=88, 73.3%) with a mean age of 68.28 years (SD11.54). Daptomycin was most frequently prescribed for osteoarticular infections (n=75, 62.5%) and to treat gram-positive cocci infections. The most frequently isolated pathogen was Methicillin-resistant Staphylococcus aureus (MRSA). Daptomycin was mostly used with off-label indications (n=89, 74%). Symptoms of AEP were usually reported after a mean of 21.75 days of treatment (range 3-84) and typically included fever, dyspnea, dry cough and acute respiratory failure. Reported treatment strategies invariably included daptomycin withdrawal, respiratory support, and corticosteroid treatment. One hundred and sixteen patients fully recovered. A fatal outcome was described in 4 patients. Suggestive symptoms and imaging raised suspicion for AEP, confirmed with bronchoalveolar lavage in 57.5% of the cases. Discussion and Conclusions Daptomycin-induced AEP is a rare but potentially fatal complication, mostly reported after long treatment with daptomycin. Clinicians should be aware of this syndrome, as it could be initially misdiagnosed for an acute infectious respiratory syndrome, resulting in a delay in its diagnosis and treatment. Furthermore, since the risk of developing AEP is increased by longer drug exposure, caution should be used when discussing the use of daptomycin in longer treatment regimens.
DOI: 10.6084/m9.figshare.24551092.v1
title: Supplementary Material for: Daptomycin-induced eosinophilic pneumonia: a case report and systematic review.

description: Introduction Acute eosinophilic pneumonia (AEP) is a rare respiratory condition caused by eosinophil accumulation in the pulmonary tissue that can be related to drug administration. Daptomycin, an antibiotic active against gram-positive bacteria, is one of the leading causes of AEP among drugs. In order to raise awareness of this rare syndrome, in our work we have described a case of an 82 years-old male with Enterococcus faecalis endocarditis treated with daptomycin, who developed a daptomycin-induced AEP. We have performed a systematic review of the literature for all similar reported cases. Methods The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. To conduct the analysis, the terms “daptomycin AND eosinoph* AND pneum*”, were entered the databases Medline, Cinahl and Embase on April 13th, 2023. We considered relevant all records documenting AEP after daptomycin use. No restrictions in terms of year or language were made. A formal appraisal of observational studies was performed by Newcastle-Ottawa Scale. All results and data were reported by means of tables. Results Our search identified 93 relevant records, published between 2007 and 2023. A total of 120 patients were considered. Patients who experienced AEP were mostly males (n=88, 73.3%) with a mean age of 68.28 years (SD11.54). Daptomycin was most frequently prescribed for osteoarticular infections (n=75, 62.5%) and to treat gram-positive cocci infections. The most frequently isolated pathogen was Methicillin-resistant Staphylococcus aureus (MRSA). Daptomycin was mostly used with off-label indications (n=89, 74%). Symptoms of AEP were usually reported after a mean of 21.75 days of treatment (range 3-84) and typically included fever, dyspnea, dry cough and acute respiratory failure. Reported treatment strategies invariably included daptomycin withdrawal, respiratory support, and corticosteroid treatment. One hundred and sixteen patients fully recovered. A fatal outcome was described in 4 patients. Suggestive symptoms and imaging raised suspicion for AEP, confirmed with bronchoalveolar lavage in 57.5% of the cases. Discussion and Conclusions Daptomycin-induced AEP is a rare but potentially fatal complication, mostly reported after long treatment with daptomycin. Clinicians should be aware of this syndrome, as it could be initially misdiagnosed for an acute infectious respiratory syndrome, resulting in a delay in its diagnosis and treatment. Furthermore, since the risk of developing AEP is increased by longer drug exposure, caution should be used when discussing the use of daptomycin in longer treatment regimens.
DOI: 10.21227/wbpx-7736
title: Thermocouple Degradation data in Corrosive environments 

description: Thermocouples are widely used in industrial applications due to their robustness, low cost, reliability and ability to survive in harsh environments. However, these thermocouples are prone to failure in a highly acidic medium such as nuclear fuel reprocessing plants. This paper investigates the degradation phenomenon and its effect on measurement accuracy when a thermocouple with mechanical damage to the protective sheath is placed in a corrosive media. This work takes a novel approach of micro-machining a small hole in the thermocouple to mimic sheath damage, which enables the corrosive medium to directly interact with the sensing material, i.e., Chromel and Alumel. The thermocouples with artificially induced sheath defects are then subjected to ageing in different concentrations of acidic media at a constant temperature, while degradation data i.e. temperature is read and logged. The time-to-failure data of thermocouples at each concentration is analyzed using the Weibull distribution. Inverse Power Law is then used to model the life-stress relationship under a ruptured sheath condition. The study also explores the correlation between the residual life and the position of simulated ruptures. ANOVA is employed to test the hypotheses regarding the influence of rupture position on thermocouple performance. The analysis results show that the location of damage is statistically significant in determining the thermocouple’s residual life under damaged sheath condition.
DOI: 10.22008/fk2/rj35bw/tsdczm
title: DK_Formation_tops_v_1-4 Frisbee.xlsx

description: :unav
DOI: 10.22008/fk2/rj35bw
title: Formation tops for deep exploration wells drilled in Denmark, v. 1.5

description: Compilation of lithostratigraphic tops in deep Danish exploration wells with information on source of data
DOI: 10.22008/fk2/rj35bw/dfpykl
title: DK_Formation_tops_v_1-5 Frisbee.xlsx

description: In v. 1.5 well tops have been updated for several wells. Missing wells have been added (Frida-1, Francisca-1, G-1X).
DOI: 10.5258/soton/d2704
title: Dataset in support of the journal article 'A workflow for identifying viable crystal structures with partially occupied sites applied to solid electrolyte: Cubic Li$_7$La$_3$Zr$_2$O$_{12}$'

description: c-LLZO Structures A data set containing all c-LLZO structures that are symmetrically unique and have a Li-Li spacing of over 1.7 angstrom, It is accompanied by a csv file which contains energy and symmetry assignments
DOI: 10.6084/m9.figshare.24523273
title: Supplementary Material for: Non-familial Bilateral Synchronous Renal Cell Carcinoma with Discordant Histology with Eventual Complete Response to Dual Immunotherapy

description: Bilateral synchronous renal cell carcinoma (RCC) is rare, especially in sporadic rather than familial cases. While immunotherapy has improved prognosis, RCC remains a diagnosis with significant morbidity and mortality, particularly pronounced in patients with sarcomatoid RCC (sRCC). We describe a case of a patient with bilateral, synchronous, non-familial RCC, with and without sarcomatoid features and differing genetic markers, who demonstrated a pathologic response after neoadjuvant nivolumab and ipilimumab. The patient then had radical left nephrectomy and partial right nephrectomy followed by adjuvant nivolumab and cabozantinib, after which the patient had no evidence of disease. Our patient’s illustrative case shows the potential therapeutic value of immunotherapy even in sRCC, the disease’s most aggressive clinical subtype.
DOI: 10.6084/m9.figshare.24384448
title: Supplementary Material for: HMGB1 induced oxidative stress and Inflammation in endothelial cells exposed to Impinging Flow

description: Abstract Background: Oxidative stress and inflammation contribute to many aspects of the pathological processes involved in intracranial aneurysm (IA). However, the underlying mechanism for inducing oxidative stress and inflammation under impinging flow remains unclear. Accumulating evidence has shown that High mobility group box-1 (HMGB1) is associated with oxidative stress-related chronic diseases and inflammatory responses. Therefore, we aimed to investigate whether HMGB1 is involved in oxidative stress and inflammatory responses in endothelial cells (ECs) exposed to impinging flow. Methods: We used a modified T-chamber to simulate the in vitro situation of human umbilical vein endothelial cells (HUVECs) subjected to impinging flow at the arterial bifurcation in order to analyze the effect of wall shear stress (WSS) on the ECs. To investigate the role of HMGB1 in this process, we transfected ECs with shRNA before conducting impinging flow experiments. Intracellular reactive oxygen species (ROS) were measured by flow cytometry, and malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels were measured to assess oxidative stress. Inflammation was assessed by measuring the mRNA expression levels of IL-1β, IL-6 and IL-8 using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We also examined the cellular localisation of HMGB1 by immunofluorescence. Results: Exposure of HUVECs to WSS can increase the level of oxidative stress and inflammatory response. WSS increased the expression of HMGB1 in ECs and promoted the translocation of HMGB1 from cytosol to cytoplasm. When we knocked down HMGB1, the level of oxidative stress and inflammatory response caused by WSS in ECs decreased, suggesting that HMGB1 can mediate the oxidative stress and inflammatory response in HUVECs exposed to WSS. Conclusions：HMGB1 induced oxidative stress and inflammatory response in ECs exposed to Impinging Flow.
DOI: 10.6084/m9.figshare.24384448.v1
title: Supplementary Material for: HMGB1 induced oxidative stress and Inflammation in endothelial cells exposed to Impinging Flow

description: Abstract Background: Oxidative stress and inflammation contribute to many aspects of the pathological processes involved in intracranial aneurysm (IA). However, the underlying mechanism for inducing oxidative stress and inflammation under impinging flow remains unclear. Accumulating evidence has shown that High mobility group box-1 (HMGB1) is associated with oxidative stress-related chronic diseases and inflammatory responses. Therefore, we aimed to investigate whether HMGB1 is involved in oxidative stress and inflammatory responses in endothelial cells (ECs) exposed to impinging flow. Methods: We used a modified T-chamber to simulate the in vitro situation of human umbilical vein endothelial cells (HUVECs) subjected to impinging flow at the arterial bifurcation in order to analyze the effect of wall shear stress (WSS) on the ECs. To investigate the role of HMGB1 in this process, we transfected ECs with shRNA before conducting impinging flow experiments. Intracellular reactive oxygen species (ROS) were measured by flow cytometry, and malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels were measured to assess oxidative stress. Inflammation was assessed by measuring the mRNA expression levels of IL-1β, IL-6 and IL-8 using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We also examined the cellular localisation of HMGB1 by immunofluorescence. Results: Exposure of HUVECs to WSS can increase the level of oxidative stress and inflammatory response. WSS increased the expression of HMGB1 in ECs and promoted the translocation of HMGB1 from cytosol to cytoplasm. When we knocked down HMGB1, the level of oxidative stress and inflammatory response caused by WSS in ECs decreased, suggesting that HMGB1 can mediate the oxidative stress and inflammatory response in HUVECs exposed to WSS. Conclusions：HMGB1 induced oxidative stress and inflammatory response in ECs exposed to Impinging Flow.
DOI: 10.6084/m9.figshare.24211398
title: Climate, host ontogeny and pathogen structural specificity determine forest disease distribution at a regional scale

description: Excel file with the data used in the study.
DOI: 10.5258/soton/d2846
title: Dataset in support of the thesis 'Attachment in psychosis; Intra- and interpersonal processes affecting recovery'

description: Thesis project data for the award of Doctorate in Clinical Psychology this dataset is associated with Chapter 2: The role of attachment on emotional regulation, help-seeking, service engagement and recovery in psychosis Quantitative data for 65 participants collected using questionnaire methodology. Collected on the online survey platform Qualtrics. Data was downloaded and transferred to Statistical Package for Social Sciences Software (SPSS) version 28 for analyses. Thesis Award date: December 2023. ORCID ID: 0000-0002-5929-7756
DOI: 10.6084/m9.figshare.24516529
title: Supplementary Material for: Diagnostic performance of bile duct brush cytology with risk of malignancy of standardized categories in the wake of World Health Organization Reporting System for Pancreaticobiliary Cytopathology: An updated systematic review and meta-analysis

description: Introduction: The WHO Reporting System for Pancreaticobiliary Cytopathology revised the Papanicolaou Society of Cytopathology guidelines in alignment with the WHO classification of digestive system tumors, 5th edition. The current systematic review and meta-analysis have been conducted to accurately assess the performance of bile duct brush cytology and report the risk of malignancy (ROM) of each standard category by following the guidelines of diagnostic test accuracy meta-analysis. Methods: Medline/ Pubmed and Cochrane databases were searched till 8th June 2023 with a strategy that included target site (pancreaticobiliary and related terms), diagnostic method (bile duct brushing and related terms), and keywords for diagnostic performance (for Cochrane database). Inclusion criteria included studies that have assessed bile duct cytology (BDC) for pancreaticobiliary duct stricture with a sample size of over 50, provided cytological diagnoses similar to the WHO system with details to deduce true positives, true negatives, false positives, and false negatives through subsequent final diagnoses (Benign vs. Malignant). The exclusion criteria were the fewer sample size, assessment through other cytological categories, limited data, and clinical setting. Two authors independently reviewed the result of the search strategy. The quality of the selected articles was assessed by the QUADAS-2 tool. Bivariate random-effects model was used to get the pooled sensitivity and specificity. Heterogeneity across studies was assessed using I-squared statistics, and potential sources were found using meta-regression. Pooled and a range of ROM in each category was analyzed. Results: Thirteen studies were included with 4398 bile duct brushings. The pooled sensitivity is 0.437 (95% CI: 0.371-0.504), and the pooled specificity is 0.972 (95% CI: 0.943-0.987). The ROM in various categories are as follows: inadequate/non-diagnostic: 23%-100% (pooled- 50.15%), benign/negative for malignancy: 22%-70% (38%), atypical: 0%-95% (66%), suspicious for malignancy: 74%-100% (89%), malignant: 91% to 100% (98%). Conclusion: Even with standard cytological categories, the sensitivity of BDC remains low. The review has analyzed and discussed potential causes of heterogeneity that will be helpful for future diagnostic studies.
DOI: 10.21227/qqba-4a31
title: Discrete Hierarchical Conditional Variational Auto-Encoder and Self Attention Mechanism

description: The evaluations are modified with the feed back mechanism based on optimal model in Large Scale Group Decision Making (LSGDM) usually, the intelligent decision making cannot be achieved with end-to-end. The application of LSGDM is limited, such as the customer evaluation to sales factors, the most customers would not modify the provided evaluations. A novel method combining Conditional Variational Auto-Encoder (CVAE) and self attention mechanism is developed to conduct the intelligent decision making with end-to-end. After the evaluators provide the evaluations through pair-wise comparison of factors using Lginstic Preference Relation (LPR), the authors first construct the Discrete Hierarchical Conditional Variational Auto-Encoder (DHCVAE) model to generate the matrices with high consistency level according to the transformed matrices from the individual evaluations, and the quality of generated matrix is also improved. Second, the authors develop the method to aggregate the generated matrices to obtain the final consensus matrix via self attention mechanism. In the process of constructed self attention, all matrices would nearly reach consensus. The method deploys the action-state transition and policy gradient optimization to converge the process of constructed self attention quickly. The case study is conducted to verify the advantages of the developed method and the comparisons with other state-of-arts are also conducted. This data set is used in the case study.