cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25140689.v1
title: all_editors_jounals_final.csv

description: This dataset presents a comprehensive portrait of the editorship phenomenon in Innovation Studies by probing the structural features of the boards of 20 leading innovation-oriented journals as of 2019.
DOI: 10.6084/m9.figshare.12315749
title: EC/SMC coculture images

description: These rar files contain all the images used in our study, including phase-contrast images(with 'B_RGB' in names) and fluorescent images (with 'F_RGB' in names). Combined with the codes shared provided in the article, one can use these images to replicate our results.The ‘High_Density’ zip file contains all the original phase-contrast and fluorescent images with the three relatively high culture densities (4, 6, 7 × 10^4 cells / cm2).The 'DAPI binary' file contains the twenty DAPI images and the corresponding manually binarized images used to train the binarization UNet model.
DOI: 10.6084/m9.figshare.14920958
title: Additional file 3 of Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis

description: Supplementary Table 2. Marker genes of overall t-stochastic neighbor embedding map.
DOI: 10.6084/m9.figshare.20163839.v1
title: Analysing climatic variability and extremes events in the Himalayan regions focusing on mountainous urban agglomerations

description: The present study highlights the long-term variations in temperature and precipitation using time series datasets of CRU and ERA5-Land across the Himalayan region. The Mann-Kendall and Sen’s slope-based trend analysis exhibited an apparent warming trend in the region, with higher increase in Tmin (1.5 °C) and comparatively lower increase in Tmax (0.8 °C) during 1901–2018. The joint CCl/WCRP/JCOMM based 19 extreme indices elucidated an increasing frequency of warm days (16%) in Central Himalayan urban agglomerations (HUAs) with a declining number of cold days (−6%) and cold nights (−4%) during 2000–2019. The moderate decline in the wet days (8%) and consecutive wet days (−5 days/20 years) observed in all HUAs compared to an increasing frequency of the consecutive dry days (3 days/20 years). Study reported higher warming in Kathmandu UA, while increased precipitation in Srinagar UA, and contributes to framing climate change adaptation and mitigation strategies in the mountainous system.
DOI: 10.6084/m9.figshare.14920958.v1
title: Additional file 3 of Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis

description: Supplementary Table 2. Marker genes of overall t-stochastic neighbor embedding map.
DOI: 10.6084/m9.figshare.22785349.v1
title: Prediction of the Impact of CYP2C19 Polymorphism on Drug-Drug Interaction between Voriconazole and Tacrolimus Using Physiologically-Based Pharmacokinetic Modelling

description: Abstract Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice. In vitro studies demonstrated that the magnitude of inhibition depends on the concentration of voriconazole, while voriconazole exposure is determined by the genotype status of CYP2C19. CYP2C19 gene polymorphism challenges the management of drug-drug interactions(DDIs) between voriconazole and tacrolimus. This work aimed to predict the impact of CYP2C19 polymorphism on the DDIs by using physiologically based pharmacokinetics (PBPK) models. The precision of the developed voriconazole and tacrolimus models was reasonable by evaluating the pharmacokinetic parameters fold error, such as AUC0-24, Cmax and tmax. Voriconazole increased tacrolimus concentration immediately in all population. The simulated duration of DDIs disappearance after voriconazole withdrawal were 146h, 90h and 66h in poor metabolizers (PMs), intermediate metabolizers (IMs) and extensive metabolizers(EMs), respectively. The developed and optimized PBPK models in this study can be applied to assit the dose adjustment for tacrolimus with and without voriconazole.
DOI: 10.6084/m9.figshare.22785351
title: Impact of Coronary Artery Disease on The Outcomes of Catheter Ablation in Patients with Atrial Fibrillation

description: ABSTRACT Introduction: The objective of this study is to investigate the possible impact of coronary artery disease (CAD) on clinical outcomes of catheter ablation in patients with atrial fibrillation (AF). Methods: Patients with AF who underwent coronary computed tomography and catheter ablation were enrolled. The presence of stenotic severity and plaque, characteristics of coronary arteries, clinical data, and adverse outcomes of catheter ablation were analysed. Results: A total of 243 patients were enrolled, 100 (41%) patients with CAD. The CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65-74 years, and sex category) score of AF patients with CAD was significantly (P&lt;0.001) higher than of those without CAD. Presence of stenotic artery and plaques increased significantly with increase of CHA2DS2-VASc score (P&lt;0.05). There was no significant (P=0.342) difference in AF recurrence between patients with and without CAD (30% versus 24%). Age, AF type, duration of AF, heart failure, CHA2DS2-VASc score, left ventricular ejection fraction, and left atrial diameter were significantly (P&lt;0.05) correlated with AF recurrence in univariant analysis. Multivariable analysis revealed that duration of AF (hazard ratio [HR] 1.769), heart failure (HR 1.821), and left atrial diameter (HR 1.487, P=0.022) remained significant independent predictors of AF recurrence. Patients with AF and concomitant CAD were significantly (P=0.030) associated with a worse outcome. Conclusion: CAD concomitant with AF may be associated with a worse clinical outcome even though CAD does not significantly affect the risk of AF recurrence after ablation therapy.
DOI: 10.6084/m9.figshare.14921042.v1
title: Additional file 2 of Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae

description: Additional file 2: Table S1. Predicted functional residues of Spt15 using the MutFunc database.
DOI: 10.6084/m9.figshare.14921048.v1
title: Additional file 4 of Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae

description: Additional file 4: Table S3. Primers used in this study.
DOI: 10.6084/m9.figshare.8105270
title: Additional file 12: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S6. Gene information from the global signal transduction network analysis. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.8105270.v1
title: Additional file 12: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S6. Gene information from the global signal transduction network analysis. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.8105306.v1
title: Additional file 3: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S2. The differently expressed genes identified by IRIâ +â RPostC vs. IRI vs. control comparison. (XLSX 203 kb)
DOI: 10.6084/m9.figshare.14921057
title: Additional file 7 of Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae

description: Additional file 7: Dataset S3. SDEG lists in the comparisons of Spt15 mutants vs. WT at thermal stress condition.
DOI: 10.6084/m9.figshare.14921006
title: Additional file 1 of Glycolate oxidase-dependent H2O2 production regulates IAA biosynthesis in rice

description: Additional file 1.
DOI: 10.6084/m9.figshare.14921063.v1
title: Additional file 9 of Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae

description: Additional file 9: Dataset S5. Clustered TFs (A) and SDE-TFs (B) regulating SDEGs.
DOI: 10.6084/m9.figshare.8105282.v1
title: Additional file 14: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S7. Gene information from the co-expression network analysis. (XLSX 67 kb)
DOI: 10.6084/m9.figshare.8105321
title: Additional file 7: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S5. The differently expressed genes identified by IRIâ +â RPostC vs. control comparison. (XLSX 3603 kb)
DOI: 10.6084/m9.figshare.14921006.v1
title: Additional file 1 of Glycolate oxidase-dependent H2O2 production regulates IAA biosynthesis in rice

description: Additional file 1.
DOI: 10.6084/m9.figshare.8105294.v1
title: Additional file 1: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S1. The primer sequences used in the qPCR assay. (XLSX 31 kb)
DOI: 10.6084/m9.figshare.7580936.v1
title: Additional file 2 of Decrease of gene expression diversity during domestication of animals and plants

description: Table S8. provides the mapping information for the seven pairs. Table S9. provides information about the resequencing data for rice. Table S10. provides the candidate selected genes for rice. Table S11. presents the expression diversity of the seven pairs. (XLSX 149 kb)
DOI: 10.6084/m9.figshare.8105282
title: Additional file 14: of Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

description: Table S7. Gene information from the co-expression network analysis. (XLSX 67 kb)
DOI: 10.6084/m9.figshare.14921042
title: Additional file 2 of Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae

description: Additional file 2: Table S1. Predicted functional residues of Spt15 using the MutFunc database.
DOI: 10.6084/m9.figshare.11267456
title: Interfacial bond-slip relationship between Carbon Fiber Reinforced Polymer Plate and Concrete after High Temperature of Asphalt Paving Construction

description: Abstract The bond-slip relationship of Carbon Fiber Reinforced Polymer (CFRP) plate-concrete after the influence of high temperature action of Stone Mastic Asphalt (SMA) paving was investigated in this article. Two groups of double shear specimens with different bonding length were designed and tested. Based on the test results, the failure modes of specimens, the strain distribution and the shear stress of CFRP-concrete interface were analyzed. Considering the influence of high temperature, the interfacial bond-slip constitutive model of CFRP plate and concrete after high temperature action of SMA paving construction was proposed. The proposed model can reflect the nonlinearity and interface softening behaviour of the CFRP plate-concrete interface constitutive relationship under special environment. Through the comparative study of exixting constitutive models, the interface bond-slip constitutive model proposed in this paper considers the effect of high temperature and has good agreement with the test results.
DOI: 10.6084/m9.figshare.11267456.v1
title: Interfacial bond-slip relationship between Carbon Fiber Reinforced Polymer Plate and Concrete after High Temperature of Asphalt Paving Construction

description: Abstract The bond-slip relationship of Carbon Fiber Reinforced Polymer (CFRP) plate-concrete after the influence of high temperature action of Stone Mastic Asphalt (SMA) paving was investigated in this article. Two groups of double shear specimens with different bonding length were designed and tested. Based on the test results, the failure modes of specimens, the strain distribution and the shear stress of CFRP-concrete interface were analyzed. Considering the influence of high temperature, the interfacial bond-slip constitutive model of CFRP plate and concrete after high temperature action of SMA paving construction was proposed. The proposed model can reflect the nonlinearity and interface softening behaviour of the CFRP plate-concrete interface constitutive relationship under special environment. Through the comparative study of exixting constitutive models, the interface bond-slip constitutive model proposed in this paper considers the effect of high temperature and has good agreement with the test results.
DOI: 10.6084/m9.figshare.14385586
title: Additional file 1 of Role of tumor mutation burden-related signatures in the prognosis and immune microenvironment of pancreatic ductal adenocarcinoma

description: Additional file 1: Figure S1. GO analysis and GSEA of the TRGs. (A) GO analysis showed the function of TRGs. (B) GSEA showed differentially enriched pathways of TRGs using the GO gene-sets. Figure S2. Mutational landscape of the TMB_high and TMB_low groups. Figure S3. Lasso regression identifies 16 TRGs for model construction. (A) The curve shows that the partial likelihood deviance changed along with the lambda value. The lambda value is determined when the partial likelihood deviance is at its minimum value. (B) When the lambda value is determined, the corresponding coefficient of each gene can be determined. Figure S4. Validation of the constructed model using the same coefficients and cutoff values. (A) PDAC patients were divided into high- and low-risk groups based on their scores calculated by the model. (B) The survival time and status of PDAC patients varied with increasing risk scores. (C) Patients with low lasso risk scores had prolonged OS. (D) Patients with high lasso risk scores featured increased cumulative hazards. (E) ROC curve to assess the accuracy of the model. Figure S5. The differential expression of four genes in the prognostic model based on bulk sequencing and qPCR validation. Target genes from left to right were GBP1, HIST1H1C, MMP28 and PPP1R15A, respectively. Cell-lines from top to bottom were capan-1, panc-1, Mia-paca-2 and SW1990. Figure S6. Correlation analysis between ANKRD55 expression and immune checkpoints (A) DNA transmethylases (B) and DNA repair-related proteins (C). Table S1. Primer sequencing of the genes that need to be validate by PCR. Table S2. A summary of survival-associated TRGs in PDAC. Table S3. Genes used in the construction of prognosis model. Table S4. Characterization of validation cohorts. Table S5. The association between CD8 + T cells infiltration and TMB score.
DOI: 10.6084/m9.figshare.22785351.v1
title: Impact of Coronary Artery Disease on The Outcomes of Catheter Ablation in Patients with Atrial Fibrillation

description: ABSTRACT Introduction: The objective of this study is to investigate the possible impact of coronary artery disease (CAD) on clinical outcomes of catheter ablation in patients with atrial fibrillation (AF). Methods: Patients with AF who underwent coronary computed tomography and catheter ablation were enrolled. The presence of stenotic severity and plaque, characteristics of coronary arteries, clinical data, and adverse outcomes of catheter ablation were analysed. Results: A total of 243 patients were enrolled, 100 (41%) patients with CAD. The CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65-74 years, and sex category) score of AF patients with CAD was significantly (P&lt;0.001) higher than of those without CAD. Presence of stenotic artery and plaques increased significantly with increase of CHA2DS2-VASc score (P&lt;0.05). There was no significant (P=0.342) difference in AF recurrence between patients with and without CAD (30% versus 24%). Age, AF type, duration of AF, heart failure, CHA2DS2-VASc score, left ventricular ejection fraction, and left atrial diameter were significantly (P&lt;0.05) correlated with AF recurrence in univariant analysis. Multivariable analysis revealed that duration of AF (hazard ratio [HR] 1.769), heart failure (HR 1.821), and left atrial diameter (HR 1.487, P=0.022) remained significant independent predictors of AF recurrence. Patients with AF and concomitant CAD were significantly (P=0.030) associated with a worse outcome. Conclusion: CAD concomitant with AF may be associated with a worse clinical outcome even though CAD does not significantly affect the risk of AF recurrence after ablation therapy.
DOI: 10.6084/m9.figshare.11267600
title: Mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and inflammation

description: Abstract Purpose: To investigate the effect of mesenteric lymph drainage on the spleen injury and the expressions of inflammatory cytokines in splenic tissue in mice following hemorrhagic shock. Methods: Male C57 mice were randomly divided into the sham shock, shock and shock+drainage groups. The mice in both shock and shock+drainage groups suffered femoral artery bleeding, maintained mean arterial pressure (MAP) of 40±2 mmHg for 90 min, and were resuscitated. And mesenteric lymph drainage was performed in the shock+drainage group at the time of resuscitation. After three hours of resuscitation, the splenic tissues were harvested for the histological observation and protein and mRNA expression analysis of cytokines. Results: The spleen in the shock group revealed a significantly structural damage and increased mRNA expressions of MyD88 and TRAF6 and protein expressions of TIPE2, MyD88, TRIF and TRAF3 compared to the sham group. By contrast, the splenic pathological injury in the shock+drainage group was alleviated significantly, and the mRNA and protein expressions of TIPE2, MyD88, TRIF, TRAF3 and TRAF6 were significantly lower than those in the shock group. Conclusion: These results indicate that post-hemorrhagic shock mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and the expressions of inflammatory cytokines.
DOI: 10.6084/m9.figshare.11267600.v1
title: Mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and inflammation

description: Abstract Purpose: To investigate the effect of mesenteric lymph drainage on the spleen injury and the expressions of inflammatory cytokines in splenic tissue in mice following hemorrhagic shock. Methods: Male C57 mice were randomly divided into the sham shock, shock and shock+drainage groups. The mice in both shock and shock+drainage groups suffered femoral artery bleeding, maintained mean arterial pressure (MAP) of 40±2 mmHg for 90 min, and were resuscitated. And mesenteric lymph drainage was performed in the shock+drainage group at the time of resuscitation. After three hours of resuscitation, the splenic tissues were harvested for the histological observation and protein and mRNA expression analysis of cytokines. Results: The spleen in the shock group revealed a significantly structural damage and increased mRNA expressions of MyD88 and TRAF6 and protein expressions of TIPE2, MyD88, TRIF and TRAF3 compared to the sham group. By contrast, the splenic pathological injury in the shock+drainage group was alleviated significantly, and the mRNA and protein expressions of TIPE2, MyD88, TRIF, TRAF3 and TRAF6 were significantly lower than those in the shock group. Conclusion: These results indicate that post-hemorrhagic shock mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and the expressions of inflammatory cytokines.
DOI: 10.6084/m9.figshare.11267612
title: Corneal differences between healthy and subclinical patients assessed using two diferente corneal tomographers

description: ABSTRACT Purpose: To analyze subclinical keratoconus topography indexes using Pentacam and Orbscan-II measurements to identify evidences for seeking sensitive indexes to screen and diagnose subclinical keratoconus. Methods: Fifty healthy participants (50 eyes) and 40 patients with subclinical keratoconus (40 eyes) were included. Seven common parameters including corneal thickness at the thinnest point; minimum curvature of the front surface (minimum simulated keratometry value, SimK’s Min); maximum curvature of the front surface (maximum simulated keratometry value, SimK’s Max); the frontal corneal surface best-fit spherical radius of the curvature; the back corneal surface best-fit spherical radius of curvature; the anterior corneal surface height (anterior Diff value); and the posterior corneal surface height (posterior Diff value) measured by Pentacam and Orbscan-II between normal and subclinical keratoconus eyes were compared. Results: Statistical differences between the healthy and subclinical keratoconus groups (p&lt;0.01) were found in all corneal parameters measured using both devices. Differences in the minimum curvature of the front surface (SimK’s Min), thinnest point, anterior Diff value, and posterior Diff value were significant between Pentacam and Orbscan-II in the subclinical keratoconus group (p&lt;0.05). Conclusion: The findings of this study identify the differences between normal and subclinical keratoconus eyes at the minimum curvature of the front surface, maximum curvature of the front surface, frontal corneal surface best-fit spherical radius of curvature, back corneal surface best-fit spherical radius of curvature, Anterior Diff value, and Posterior Diff value measures using Orbscan II and Pentacam that can help eye care practitioners clinically diagnose subclinical keratoconus.
DOI: 10.6084/m9.figshare.11267612.v1
title: Corneal differences between healthy and subclinical patients assessed using two diferente corneal tomographers

description: ABSTRACT Purpose: To analyze subclinical keratoconus topography indexes using Pentacam and Orbscan-II measurements to identify evidences for seeking sensitive indexes to screen and diagnose subclinical keratoconus. Methods: Fifty healthy participants (50 eyes) and 40 patients with subclinical keratoconus (40 eyes) were included. Seven common parameters including corneal thickness at the thinnest point; minimum curvature of the front surface (minimum simulated keratometry value, SimK’s Min); maximum curvature of the front surface (maximum simulated keratometry value, SimK’s Max); the frontal corneal surface best-fit spherical radius of the curvature; the back corneal surface best-fit spherical radius of curvature; the anterior corneal surface height (anterior Diff value); and the posterior corneal surface height (posterior Diff value) measured by Pentacam and Orbscan-II between normal and subclinical keratoconus eyes were compared. Results: Statistical differences between the healthy and subclinical keratoconus groups (p&lt;0.01) were found in all corneal parameters measured using both devices. Differences in the minimum curvature of the front surface (SimK’s Min), thinnest point, anterior Diff value, and posterior Diff value were significant between Pentacam and Orbscan-II in the subclinical keratoconus group (p&lt;0.05). Conclusion: The findings of this study identify the differences between normal and subclinical keratoconus eyes at the minimum curvature of the front surface, maximum curvature of the front surface, frontal corneal surface best-fit spherical radius of curvature, back corneal surface best-fit spherical radius of curvature, Anterior Diff value, and Posterior Diff value measures using Orbscan II and Pentacam that can help eye care practitioners clinically diagnose subclinical keratoconus.