cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.11714639
title: P(Y)ROTYLENOL®

description: Spit small amount of saliva onto piece of aluminum foil.

Heat with fire pyrophosphate until it burns into residue  from other side of aluminum foil.

Isolate salts; suprisingly salty to taste.





















Exploring acetaminophen prodrugs and hybrids: a review





 



National Institutes of Health (NIH) (.gov)

https://www.ncbi.nlm.nih.gov › articles › PMC10958773











 



 

 














 












by VV Kouznetsov · 2024 — Acetaminophen (APAP, known as paracetamol) and nonsteroidal anti ... Among them, sodium phosphate 29 is in vivo hydrolyzable to APAP ...






 













Things to know






  

 

Patents






 

  

 




 

 
















Salts of acetaminophen





Abstract



Isolated salts of acetaminophen are disclosed. Alkali metal and alkaline-earth metal salts of acetaminophen were formed by reacting the free acid of acetaminophen with the corresponding metal hydroxide and then immediately isolating the resulting salt. These salts have been found to be more water soluble and less bitter in taste than the free acid form of acetaminophen.

 


Classifications









 C07C233/25 Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton






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EP0946163A2

European Patent Office

\





 

Application filed by McNeil PPC Inc




1999-10-06

 

Publication of EP0946163A2




Status

 

Withdrawn


Info Patent citations (7)   Non-patent citations (1)   Cited by (3)   Legal events   Similar documents   Priority and Related Applications External links Espacenet EPO GPI EP Register Global Dossier Discuss
DOI: 10.5281/zenodo.12791595
title: KNIGHT

description: CANSISTENTLY END IN DRAW TIE

Alekhine's Defense: John Tracy Gambit
DOI: 10.15468/dl.ujfs2q
title: Occurrence Download

description: A dataset containing 323 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cyperus tenuifolius (Steud.) Dandy",
 "Continent is Africa"
 ]
}

 The dataset includes 323 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000816-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qwperu
title: Occurrence Download

description: A dataset containing 3476 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "OccurrenceStatus is Present",
 "TaxonKey is Bothrops jararaca (Wied-Neuwied, 1824)"
 ]
}

 The dataset includes 3476 records from 57 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000817-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60707/f9qg-n928
title: STEM-EELS on volatile bearing inclusions in pyrrhotite
DOI: 10.60707/y8ej-vr63
title: STEM-EELS on volatile bearing inclusions in pyrrhotite
DOI: 10.60707/83n1-fh58
title: STEM-EELS on volatile bearing inclusions in pyrrhotite
DOI: 10.15468/dl.5ugzwu
title: Occurrence Download

description: A dataset containing 29913 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Arthroceras subterminale (Parish) Piirainen & G.Kadereit, Salicornia L., Arthrocaulon Piirainen & G.Kadereit, Halocnemum M.Bieb., Allenrolfea Kuntze, Microcnemum Ung.-Sternb., Halopeplis Ung.-Sternb., Mangleticornia P.W.Ball, G.Kadereit & Cornejo, Halostachys C.A.Mey., Heterostachys Ung.-Sternb., Kalidium Moq., Tecticornia Hook.f.)",
 "HasCoordinate is true",
 "BasisOfRecord is Specimen"
 ]
}

 The dataset includes 29913 records from 446 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000818-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60707/q0a8-td49
title: STEM-EELS on volatile bearing inclusions in pyrrhotite
DOI: 10.6084/m9.figshare.24085107
title: Cross-tolerance evolution is driven by selection on heat tolerance in <i>Drosophila subobscura</i>

description: Evolution of heat tolerance is a crucial mechanism for the adaptive response to global warming, but it depends on the genetic variance harbored by populations and the thermal stress intensity in nature. Selection experiments on heat tolerance have been key to understanding the heat tolerance evolution but the effect of variable heat stress intensity on the correlated responses of resistance traits has not been explored. Here, the effects of heat intensity selection (fast and slow ramping temperatures) for increasing knockdown temperature in <i>Drosophila subobscura</i> were evaluated on the knockdown time at different stressful temperatures (35, 36, 37, and 38 ºC), the thermal-death-time curves (TDT curves), the desiccation and starvation resistance. Correlated evolution was found for these four resistance traits in <i>D. subobscura</i>, which demonstrates that the evolutionary response to tolerate higher temperatures also confers the capacity to tolerate other stress such as desiccation and starvation. However, these correlated responses depended on the intensity of thermal selection and sex, which could limit our capacities to transfer these findings to natural scenarios. Nevertheless, this study reaffirms the value of the experimental evolutionary approach to explore and understand the adaptive responses of natural populations to global warming.
DOI: 10.6084/m9.figshare.24085107.v6
title: Cross-tolerance evolution is driven by selection on heat tolerance in <i>Drosophila subobscura</i>

description: Evolution of heat tolerance is a crucial mechanism for the adaptive response to global warming, but it depends on the genetic variance harbored by populations and the thermal stress intensity in nature. Selection experiments on heat tolerance have been key to understanding the heat tolerance evolution but the effect of variable heat stress intensity on the correlated responses of resistance traits has not been explored. Here, the effects of heat intensity selection (fast and slow ramping temperatures) for increasing knockdown temperature in <i>Drosophila subobscura</i> were evaluated on the knockdown time at different stressful temperatures (35, 36, 37, and 38 ºC), the thermal-death-time curves (TDT curves), the desiccation and starvation resistance. Correlated evolution was found for these four resistance traits in <i>D. subobscura</i>, which demonstrates that the evolutionary response to tolerate higher temperatures also confers the capacity to tolerate other stress such as desiccation and starvation. However, these correlated responses depended on the intensity of thermal selection and sex, which could limit our capacities to transfer these findings to natural scenarios. Nevertheless, this study reaffirms the value of the experimental evolutionary approach to explore and understand the adaptive responses of natural populations to global warming.
DOI: 10.15468/dl.bb3yn4
title: Occurrence Download

description: A dataset containing 617 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cyperus tenuis Sw.",
 "Continent is Africa"
 ]
}

 The dataset includes 617 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000819-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b6kx7k
title: Occurrence Download

description: A dataset containing 3801 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-85.61736 10.60216,-85.4916 10.60216,-85.4916 10.68674,-85.61736 10.68674,-85.61736 10.60216))",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 3801 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000822-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kafbas
title: Occurrence Download

description: A dataset containing 429 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cyperus tenuispica Steud.",
 "Continent is Africa"
 ]
}

 The dataset includes 429 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000820-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/11256089
title: Top Spotify Songs in 73 Countries (Daily Updated)
DOI: 10.15468/dl.b379t4
title: Occurrence Download

description: A dataset containing 3476 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "OccurrenceStatus is Present",
 "TaxonKey is Bothrops jararaca (Wied-Neuwied, 1824)"
 ]
}

 The dataset includes 3476 records from 57 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000821-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vv6d2w
title: Occurrence Download

description: A dataset containing 1184 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-114.71771 39.17768,-104.08286 39.17768,-104.08286 48.34436,-114.71771 48.34436,-114.71771 39.17768))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Myotis lucifugus (Le Conte, 1831)"
 ]
}

 The dataset includes 1184 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000823-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28719077
title: Supplemental Data for Babicheva et al. "Store-operated Ca2+ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells"

description: Endothelial-to-mesenchymal transition (EndMT) is a biological process that converts endothelial cells to mesenchymal cells with increased proliferative and migrative abilities. EndMT has been implicated in the development of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), a fatal and progressive lung vascular disease. Transforming growth factor β<sub>1</sub> (TGF-β<sub>1</sub>), an inflammatory cytokine, is known to induce EndMT in many types of endothelial cells including lung vascular endothelial cells (LVEC). An increase in cytosolic free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>cyt</sub>) is a major stimulus for cellular proliferation and phenotypic transition, but it is unknown whether Ca<sup>2+</sup> signaling is involved in EndMT. In this study we tested the hypothesis that TGF-β<sub>1</sub>-induced EndMT in human LVEC is Ca<sup>2+</sup>-dependent. Treatment of LVEC with TGF-β<sub>1</sub> for 5-7 days resulted in increase in SNAI1/2 expression, induction of EndMT, upregulation of STIM/Orai1 and enhancement of store-operated Ca<sup>2+</sup> entry (SOCE). Removal (or chelation) of extracellular or intracellular Ca<sup>2+</sup> with EGTA or BAPTA-AM respectively abolished EndMT in response to TGF-β<sub>1</sub>. Moreover, EGTA diminished TGF-β<sub>1</sub>-induced increase in SNAI in a dose-dependent manner. Knockdown of either STIM1 or Orai1 was sufficient to prevent TGF-β-mediated increase in SNAI1/2 and EndMT, but did not rescue the continuous adherent junctions. Blockade of Orai1 channels by AnCoA4 inhibited TGF-β-mediated EndMT and restored PECAM1-positive continuous adherent junctions. In conclusion, intracellular Ca<sup>2+</sup> signaling plays a critical role in TGF-β-associated EndMT through enhanced SOCE and STIM1-Orai1 interaction. Thus, targeting Ca<sup>2+</sup> signaling pathways regulating EndMT may be a novel therapeutic approach to treat PAH and other forms of pre-capillary pulmonary hypertension.
DOI: 10.13145/bacdive110437.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110437.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102126.10fu
title: SH0102126.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110438.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110438.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102127.10fu
title: SH0102127.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110439.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110439.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102128.10fu
title: SH0102128.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110440.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102129.10fu
title: SH0102129.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110440.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110441.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102130.10fu
title: SH0102130.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110441.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110442.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102131.10fu
title: SH0102131.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110442.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110443.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0102132.10fu
title: SH0102132.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive110443.20251217.10
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive110444.20241212.9.2
title: Streptomyces sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.