cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8987831.v1
title: Population medical genetics: translating science to the community

description: Abstract Rare genetic disorders are currently in the spotlight due to the elevated number of different conditions and significant total number of affected patients. The study of these disorders is extremely helpful for the elucidation of physiological processes related with complex disorders. Isolated populations are instrumental for the study of genetic disorders, considering their homogeneity and high proportion of affected patients in a small geographic area. These favorable conditions lead to the creation of a new discipline, known as “population medical genetics”, which integrates medical genetics, population genetics, epidemiological genetics and community genetics. In order to develop practical activities in this new discipline, the National Institute of Population Medical Genetics (INaGeMP) was created in 2008 in Brazil. INaGeMP has developed several tools and funded numerous research activities. In this review, we highlight three successful projects developed in the first 10 years of INaGeMP activities (2008-2018): a newborn screening pilot study for MPS VI in Northeast Brazil, the study of Machado-Joseph disease in Brazilian families with Azorian ancestry, and the high twinning rate in a small town in southern Brazil. The results of these projects in terms of scientific output and contributions to the affected communities highlight the success and importance of INaGeMP.
DOI: 10.6084/m9.figshare.8987834.v1
title: People, Manatees and the Aquatic Environment in Early Modern Americas: Confluence and Divergence in the Historical Relationships Between Humans and Animals

description: ABSTRACT The manatee (manati of the West Indies, also called manatim or iguaragua in colonial Brazil) was highly valued and presented a broad historical geographic distribution in coastal, transitional and fluvial areas of the tropical Atlantic Ocean. Documental and iconographic sources of the 16th and 17th centuries show us that it was used as food and for medicinal purposes, to manufacture tools or even as a pet. Moreover, its economic and symbolic value was equally relevant. Continued overexploitation led to the disappearance of many populations of manatees, which are currently at the brinck of extinction. We will explore, from the point of view of marine environmental history, the pragmatic and symbolic meaning of the manatee in close connection to the importance given to rivers and watercourses. We also expect to contribute to place manatees and their ecosystem at the center of the discussion about the environmental and sociocultural contexts and interactions of indigenous and colonial societies in the Americas of the modern period.
DOI: 10.6084/m9.figshare.8987822
title: A Case of Chronic and Relapsing Paget Disease of the Vulva

description: Abstract Extramammary Paget disease is a rare neoplastic condition that more commonly affects postmenopausal Caucasian women. Although the vulvar area is the most frequently affected location, it corresponds solely to 1 to 2% of all vulvar malignancies. A 72-year-old female patient was observed in our outpatient clinic with a 2-year history of an erythematous and pruritic plaque on the vulva. Histopathology and immunohistochemistry studies were compatible with extramammary Paget disease of the vulva. Associated neoplastic conditions were excluded. Due to multiple relapses, the patient was submitted to three surgical interventions, including a total vulvectomy, and to external radiotherapy. The present case illustrates the chronic and recurrent nature of extramammary Paget disease despite aggressive procedures as well as the challenge in obtaining tumor-free resection margins.
DOI: 10.6084/m9.figshare.8987813
title: Family farming and wholesale markets: Social dynamics of the Central of Commercialization of Family farming (Cecaf / Ceasa) in Recife - Pernambuco

description: Abstract This research analyzes the social dynamics of the commercialization warehouse of family farming (Cecaf), within the scope of Ceasa, considering the social diversity, associative bases, strategies of commercialization and local disputes for the use of space. How do the daily dynamics of commercialization set up in Cecaf and who are the social actors are some of questions that lead this research. This work involved 38 interviewees, among commercial farmers and managers. Created with the purpose to serve exclusively Pronaf beneficiary family farming, Cecaf needed to broaden its target audience, given the scarcity of users that fulfilled this criterion, favoring the installation of a diversity of actors. This commercialization experiences define specific way of life and work which are nourished by a constant learning from the buying and selling strategies and through the relationships established with suppliers and customers. Knowing “everybody”, knowing how to deal with prices of products and the formal and informal rules for use of the “stones” are some of the requirements presented among farmers surveyed. Finally, it was possible to observe that the dynamics of commercialization reproduces mechanisms of dependency and subordination between more capitalized traders and other players.
DOI: 10.6084/m9.figshare.8987816
title: Schizophrenia TreAtment with electRic Transcranial Stimulation (STARTS): design, rationale and objectives of a randomized, double-blinded, sham-controlled trial

description: Abstract Introduction Schizophrenia is a severe mental disorder. While some antipsychotic medications have demonstrated efficacy in treating positive symptoms, there is no widely recognized treatment for negative symptoms, which can cause significant distress and impairment for patients with schizophrenia. Here we describe the rationale and design of the STARTS study (Schizophrenia TreAtment with electRic Transcranial Stimulation), a clinical trial aimed to test the efficacy of a non-pharmacological treatment known as transcranial direct current stimulation (tDCS) for treating the negative symptoms of schizophrenia Methods The STARTS study is designed as a randomized, sham-controlled, double-blinded trial evaluating tDCS for the treatment of the negative symptoms of schizophrenia. One-hundred patients will be enrolled and submitted to 10 tDCS sessions over the left dorsolateral prefrontal cortex (anodal stimulation) and left temporoparietal junction (cathodal stimulation) over 5 consecutive days. Participants will be assessed using clinical and neuropsychological tests before and after the intervention. The primary outcome is change in the Positive and Negative Syndrome Scale (PANSS) negative subscale score over time and across groups. Biological markers, including blood neurotrophins and interleukins, genetic polymorphisms, and motor cortical excitability, will also be assessed. Results The clinical results will provide insights about tDCS as a treatment for the negative symptoms of schizophrenia, and the biomarker investigation will contribute towards an improved understanding of the tDCS mechanisms of action. Conclusion Our results could introduce a novel therapeutic technique for the negative symptoms of schizophrenia. Clinical trial registration: ClinicalTrials.gov, NCT02535676 .
DOI: 10.6084/m9.figshare.8987819
title: RELATIONSHIPS OF PRODUCTION, WORK, ENVIRONMENT AND HEALTH IN A MULTINATIONAL AUTOMOTIVE COMPLEX IN PERNAMBUCO, BRAZIL

description: Abstract The study that originated the present article, which was conducted between 2015 and 2017, has the goal of understanding the possible relationships in the productive, environmental and sanitary contexts in the municipality of Goiana, in the state of Pernambuco, Brazil, with the arrival of the Fiat Chrysler Automobiles multinational enterprise. We aimed at developing an explanatory matrix based on the Driving force-Pressure-State-Exposure-Effect-Action framework, with the systematization of indicators for the monitoring of changes in the territory that could affect the health of the local population and the environment due to the establishment of the automotive complex. In order to do so, we proposed descriptive components for each dimension of the matrix, and we performed a systematization of secondary data in different databanks. We noticed effects on the well-being within the local context due to the territorial exposure to an increase in violence, precarization and injuries related to work, environmental contamination and precarious sanitation. In order to face the complex and systematic problems identified, we propose actions that can subsidize strategies for the vigilance in environmental health and in the health of the worker. Through the framework, we can describe processes of vulnerabilization in the local territories, associating them with productive structuring forces and changes in the social reproduction situation.
DOI: 10.6084/m9.figshare.8987822.v1
title: A Case of Chronic and Relapsing Paget Disease of the Vulva

description: Abstract Extramammary Paget disease is a rare neoplastic condition that more commonly affects postmenopausal Caucasian women. Although the vulvar area is the most frequently affected location, it corresponds solely to 1 to 2% of all vulvar malignancies. A 72-year-old female patient was observed in our outpatient clinic with a 2-year history of an erythematous and pruritic plaque on the vulva. Histopathology and immunohistochemistry studies were compatible with extramammary Paget disease of the vulva. Associated neoplastic conditions were excluded. Due to multiple relapses, the patient was submitted to three surgical interventions, including a total vulvectomy, and to external radiotherapy. The present case illustrates the chronic and recurrent nature of extramammary Paget disease despite aggressive procedures as well as the challenge in obtaining tumor-free resection margins.
DOI: 10.6084/m9.figshare.8987819.v1
title: RELATIONSHIPS OF PRODUCTION, WORK, ENVIRONMENT AND HEALTH IN A MULTINATIONAL AUTOMOTIVE COMPLEX IN PERNAMBUCO, BRAZIL

description: Abstract The study that originated the present article, which was conducted between 2015 and 2017, has the goal of understanding the possible relationships in the productive, environmental and sanitary contexts in the municipality of Goiana, in the state of Pernambuco, Brazil, with the arrival of the Fiat Chrysler Automobiles multinational enterprise. We aimed at developing an explanatory matrix based on the Driving force-Pressure-State-Exposure-Effect-Action framework, with the systematization of indicators for the monitoring of changes in the territory that could affect the health of the local population and the environment due to the establishment of the automotive complex. In order to do so, we proposed descriptive components for each dimension of the matrix, and we performed a systematization of secondary data in different databanks. We noticed effects on the well-being within the local context due to the territorial exposure to an increase in violence, precarization and injuries related to work, environmental contamination and precarious sanitation. In order to face the complex and systematic problems identified, we propose actions that can subsidize strategies for the vigilance in environmental health and in the health of the worker. Through the framework, we can describe processes of vulnerabilization in the local territories, associating them with productive structuring forces and changes in the social reproduction situation.
DOI: 10.6084/m9.figshare.8987813.v1
title: Family farming and wholesale markets: Social dynamics of the Central of Commercialization of Family farming (Cecaf / Ceasa) in Recife - Pernambuco

description: Abstract This research analyzes the social dynamics of the commercialization warehouse of family farming (Cecaf), within the scope of Ceasa, considering the social diversity, associative bases, strategies of commercialization and local disputes for the use of space. How do the daily dynamics of commercialization set up in Cecaf and who are the social actors are some of questions that lead this research. This work involved 38 interviewees, among commercial farmers and managers. Created with the purpose to serve exclusively Pronaf beneficiary family farming, Cecaf needed to broaden its target audience, given the scarcity of users that fulfilled this criterion, favoring the installation of a diversity of actors. This commercialization experiences define specific way of life and work which are nourished by a constant learning from the buying and selling strategies and through the relationships established with suppliers and customers. Knowing “everybody”, knowing how to deal with prices of products and the formal and informal rules for use of the “stones” are some of the requirements presented among farmers surveyed. Finally, it was possible to observe that the dynamics of commercialization reproduces mechanisms of dependency and subordination between more capitalized traders and other players.
DOI: 10.6084/m9.figshare.8987816.v1
title: Schizophrenia TreAtment with electRic Transcranial Stimulation (STARTS): design, rationale and objectives of a randomized, double-blinded, sham-controlled trial

description: Abstract Introduction Schizophrenia is a severe mental disorder. While some antipsychotic medications have demonstrated efficacy in treating positive symptoms, there is no widely recognized treatment for negative symptoms, which can cause significant distress and impairment for patients with schizophrenia. Here we describe the rationale and design of the STARTS study (Schizophrenia TreAtment with electRic Transcranial Stimulation), a clinical trial aimed to test the efficacy of a non-pharmacological treatment known as transcranial direct current stimulation (tDCS) for treating the negative symptoms of schizophrenia Methods The STARTS study is designed as a randomized, sham-controlled, double-blinded trial evaluating tDCS for the treatment of the negative symptoms of schizophrenia. One-hundred patients will be enrolled and submitted to 10 tDCS sessions over the left dorsolateral prefrontal cortex (anodal stimulation) and left temporoparietal junction (cathodal stimulation) over 5 consecutive days. Participants will be assessed using clinical and neuropsychological tests before and after the intervention. The primary outcome is change in the Positive and Negative Syndrome Scale (PANSS) negative subscale score over time and across groups. Biological markers, including blood neurotrophins and interleukins, genetic polymorphisms, and motor cortical excitability, will also be assessed. Results The clinical results will provide insights about tDCS as a treatment for the negative symptoms of schizophrenia, and the biomarker investigation will contribute towards an improved understanding of the tDCS mechanisms of action. Conclusion Our results could introduce a novel therapeutic technique for the negative symptoms of schizophrenia. Clinical trial registration: ClinicalTrials.gov, NCT02535676 .
DOI: 10.6084/m9.figshare.8987804
title: Determinants of farmers' opportunity cost in maintaining the legal reserve – the cases of São Paulo and Mato Grosso

description: Abstract This paper aims to estimate models that explain the determination of the opportunity cost of maintaining the legal reserve inside each farm as well as to identify possible spatial relationships among these costs. In order to reach this objective, the article uses the average cost of opportunity to holding legal reserve for the municipalities of São Paulo and Mato Grosso states in the years of 1995-96 and 2006. By using spatial econometric models, the main results indicate: (1st) there are spatial relationships among these opportunity costs; (2nd) second nature variables have more influence on these costs than the first nature variables; (3rd) there are different relationships between opportunity cost of maintaining legal reserve and the size of each farm for São Paulo and Mato Grosso states.
DOI: 10.6084/m9.figshare.8987810
title: Corrodibility and Adherence of Reinforced Concrete Rebars Electroplated with Zinc and Zinc-Nickel Alloys

description: Reinforced concrete is the main structural material used in the world in the construction of bridges, roads and commercial and residential buildings. One effective method for preventing corrosion of steel reinforcement is the application of galvanic coatings to the reinforcement itself. The present study evaluated the performance of three groups of reinforcing steel bars (black steel, used as a reference and rebars electroplated with Zinc and Zinc-Nickel alloys) to corrosion and adherence to the concrete matrix. For the analysis of corrosion, the specimens were subjected to two different accelerated corrosion tests: salt spray exposure and wet and dry semi-cycles. The corrosion potential was measured for the qualitative monitoring of the corrosion process and the corrosion rate was estimated. In order to evaluate the steel-concrete adherence, the pullout test was used, in accordance with RILEM-CEB-FIP. The results showed that Zinc and Zinc-Nickel coatings increased the durability of the reinforcing bars and the accelerated corrosion test of wetting and drying cycles proved to be more aggressive compared to the salt spray method to evaluate the corrosion process in the reinforced concrete specimens. Additionally, galvanized reinforcement reduced adherence to the concrete matrix.
DOI: 10.6084/m9.figshare.8987801
title: Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure

description: Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction &lt; 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p &lt; 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow.
DOI: 10.6084/m9.figshare.8987810.v1
title: Corrodibility and Adherence of Reinforced Concrete Rebars Electroplated with Zinc and Zinc-Nickel Alloys

description: Reinforced concrete is the main structural material used in the world in the construction of bridges, roads and commercial and residential buildings. One effective method for preventing corrosion of steel reinforcement is the application of galvanic coatings to the reinforcement itself. The present study evaluated the performance of three groups of reinforcing steel bars (black steel, used as a reference and rebars electroplated with Zinc and Zinc-Nickel alloys) to corrosion and adherence to the concrete matrix. For the analysis of corrosion, the specimens were subjected to two different accelerated corrosion tests: salt spray exposure and wet and dry semi-cycles. The corrosion potential was measured for the qualitative monitoring of the corrosion process and the corrosion rate was estimated. In order to evaluate the steel-concrete adherence, the pullout test was used, in accordance with RILEM-CEB-FIP. The results showed that Zinc and Zinc-Nickel coatings increased the durability of the reinforcing bars and the accelerated corrosion test of wetting and drying cycles proved to be more aggressive compared to the salt spray method to evaluate the corrosion process in the reinforced concrete specimens. Additionally, galvanized reinforcement reduced adherence to the concrete matrix.
DOI: 10.6084/m9.figshare.8987798
title: Utilization of bedded cattle confinement for organic manure of maize crop

description: ABSTRACT The use of organic wastes from housing systems in a compost bedded pack barn model could supply much of the fertiliser demand in the farm. Moreover, with the increase in food consumption from sustainable livestock, the use of compost generated in the farm itself becomes economically viable. This study aimed to evaluate the effect of organic manure from bedded cattle confinement applied at different moments on maize crop. The experiment was carried out in a randomized blocks with five treatments and five repetitions. The data were submitted to analysis of variance and the means were compared by Scott-Knott test at p ≤ 0.05. The treatments with addition of fresh compost and mature compost with nitrogen cover had higher production of maize shoot dry matter when compared to treatments without compost. For all variables analysed, the treatments with compost were superior to the other ones. The soil used for growing silage maize has improved considerably its chemical characteristics when the compost was applied. The use of bedding material compost from sheds as organic manure is recommended as a sustainable alternative in the reuse and treatment of waste from cattle confinement farm.
DOI: 10.6084/m9.figshare.8987804.v1
title: Determinants of farmers' opportunity cost in maintaining the legal reserve – the cases of São Paulo and Mato Grosso

description: Abstract This paper aims to estimate models that explain the determination of the opportunity cost of maintaining the legal reserve inside each farm as well as to identify possible spatial relationships among these costs. In order to reach this objective, the article uses the average cost of opportunity to holding legal reserve for the municipalities of São Paulo and Mato Grosso states in the years of 1995-96 and 2006. By using spatial econometric models, the main results indicate: (1st) there are spatial relationships among these opportunity costs; (2nd) second nature variables have more influence on these costs than the first nature variables; (3rd) there are different relationships between opportunity cost of maintaining legal reserve and the size of each farm for São Paulo and Mato Grosso states.