cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6269147.v1
title: Supplementary Material for: Effectiveness End Points in Real-World Studies on Biological Therapies in Psoriasis: Systematic Review with Focus on Drug Survival

description: Psoriasis is a complex and chronic disease, and, in most cases, therapies are required during all patients’ lifetime. The efficacy and safety profiles of biological therapies are well established, but their effectiveness is still open to discussion. We performed a systematic review to summarize how the effectiveness of biological therapies for psoriasis is measured in real-world studies and to understand whether drug survival, a recent alternative outcome to clinical ones, is a recurrent and valid outcome of effectiveness. In March 2017, we searched for quantitative epidemiological data of psoriasis treatments using PubMed/Medline and EMBASE, and we included 65 publications. The retrospective study design (37%) was most frequent, followed by prospective registries (29%), prospective studies (19%), and retrospective administrative databases/claims. Drug survival was reported in over 60% of prospective registries and retrospective studies, and less frequently in prospective studies. A general consensus emerged in the definition of drug survival as the time patients remain under treatment with a specific therapy, and in its interpretation as an overall marker of treatment success and treatment adherence, as it represents simultaneously information on drug efficacy, drug safety, and patient satisfaction. In conclusion, notwithstanding some limitations, drug survival is a useful measurement of biological therapy effectiveness for psoriasis in daily practice. Its major advantage is that it can be computed also in already collected databases without any specific clinical information on psoriasis. This outcome, combined with evidence on clinical markers of effectiveness, can contribute to better understanding the performance of this expensive class of drugs.
DOI: 10.6084/m9.figshare.6269123
title: RAAAP Codebook to Datafile matrix

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is a matrix which shoes which variables are in which of the 15 datasets. Note that the codebook (DOI:10.6084/m9.figshare.6269120) details the 293 variables, however only 292 appear in the matrix as the <i>YearsEmployed </i>variable was depricated in favour of <i>YearsEmployedGrouped</i>.
DOI: 10.6084/m9.figshare.6269123.v1
title: RAAAP Codebook to Datafile matrix

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is a matrix which shoes which variables are in which of the 15 datasets. Note that the codebook (DOI:10.6084/m9.figshare.6269120) details the 293 variables, however only 292 appear in the matrix as the <i>YearsEmployed </i>variable was depricated in favour of <i>YearsEmployedGrouped</i>.
DOI: 10.6084/m9.figshare.6269120
title: RAAAP Codebook

description: <br>The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is the codebook which details the 293 variables processed and created from the data collected in the survey
DOI: 10.6084/m9.figshare.6269120.v1
title: RAAAP Codebook

description: <br>The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is the codebook which details the 293 variables processed and created from the data collected in the survey
DOI: 10.6084/m9.figshare.6269117
title: nmr data arborinine

description: NMR spectra of arborinine<br>
DOI: 10.6084/m9.figshare.6269111
title: RAAAP SPSS Syntax file - splitting output

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is the output from the SPSS syntax file (DOI:10.6084/m9.figshare.6269090) used to split the processed data into 15 linked datasets in help keep the data anonymous. The process is described in detail in the "RAAAP Data Cleansing Process" DOI:10.6084/m9.figshare.5948461
DOI: 10.6084/m9.figshare.6269102
title: RAAAP SPSS Syntax file - splitting

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This SPSS syntax file was developed to split the processed data into 15 linked datasets in help keep the data anonymous. The process is described in detail in the "RAAAP Data Cleansing Process" DOI:10.6084/m9.figshare.5948461
DOI: 10.6084/m9.figshare.6269096
title: RAAAP SPSS Syntax file - processing output

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is the output from the SPSS syntax file (DOI: 10.6084/m9.figshare.6269090) developed to process the raw qualtrics data, including data cleansing and anonymising. The process is described in detail in the "RAAAP Data Cleansing Process" DOI:10.6084/m9.figshare.5948461
DOI: 10.6084/m9.figshare.6269096.v1
title: RAAAP SPSS Syntax file - processing output

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This is the output from the SPSS syntax file (DOI: 10.6084/m9.figshare.6269090) developed to process the raw qualtrics data, including data cleansing and anonymising. The process is described in detail in the "RAAAP Data Cleansing Process" DOI:10.6084/m9.figshare.5948461
DOI: 10.6084/m9.figshare.6269090
title: RAAAP SPSS Syntax file - processing

description: The RAAAP project surveyed Research Managers and Administrators from across the world, asking questions about why people became RMAs, why they stayed as RMAs, what skills they need for their jobs (soft and hard), what level of seniority they are, demographic information, and so on - overall up to 222 data points were collected from each respondent. This SPSS syntax file was developed to process the raw qualtrics data, including data cleansing and anonymising. The process is described in detail in the "RAAAP Data Cleansing Process" DOI:10.6084/m9.figshare.5948461
DOI: 10.6084/m9.figshare.6269057
title: raw data.xlsx

description: Raw data of figures.
DOI: 10.6084/m9.figshare.6269054
title: Supplementary Material for: Beyond Irritable Bowel Syndrome: The Efficacy of the Low Fodmap Diet for Improving Symptoms in Inflammatory Bowel Diseases and Celiac Disease

description: <b><i>Background and Aim:</i></b> To evaluate the usefulness of a low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet on patients with irritable bowel syndrome (IBS), non-active inflammatory bowel diseases (IBD), and celiac disease (CD) on a gluten-free diet (GFD). <b><i>Methods:</i></b> Dietetic interventional prospective study. IBS, IBD, and CD subjects were evaluated to check if they fulfilled the Rome III criteria. Each subject was educated to follow a low FODMAP diet after being evaluated by filling out questionnaires that assessed the quality of life (QoL) and symptoms experienced (IBS-SSS and SF-36), and was reevaluated after 1 and 3 months. <b><i>Results:</i></b> One hundred twenty-seven subjects were enrolled: 56 with IBS, 30 with IBD, and 41 with CD. IBS-SSS showed that abdominal symptoms improved after 1 and 3 months of diet in all subjects, with significant difference among the 3 groups at T0 (average scores IBS: 293 ± 137, IBD: 206 ± 86, CD: 222 ± 65, <i>p</i> &lt; 0.001), but no difference at T3 (IBS: 88 ± 54, IBD: 73 ± 45, CD: 77 ± 49, <i>p</i> = ns). By analyzing the SF-36 questionnaire, we did not observe any difference between the 3 groups, in terms of response to diet (<i>p</i> = ns), we observed a clinical improvement from T0 to T3 for most of the questionnaire’s domains. <b><i>Conclusions:</i></b> A low FODMAP diet could be a valid option to counter ­abdominal symptoms in patients with IBS, non-active IBD, or CD on a GFD, and thus, improve their QoL and social ­relations.
DOI: 10.6084/m9.figshare.6269057.v1
title: raw data.xlsx

description: Raw data of figures.
DOI: 10.6084/m9.figshare.6269051
title: Supplementary Material for: High Intraperitoneal Interleukin-6 Levels Predict Peritonitis in Peritoneal Dialysis Patients: A Prospective Cohort Study

description: <b><i>Background:</i></b> To evaluate the predictive value of dialysate interleukin-6 (IL-6) representing local subclinical intraperitoneal inflammation for the development of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. <b><i>Methods:</i></b> Stable prevalent CAPD patients were enrolled in this prospective study. IL-6 concentration in the overnight effluent was determined and expressed as the IL-6 appearance rate (IL-6AR). Patients were divided into 2 groups according to the median of IL-6AR and prospectively followed up until the first episode of peritonitis, cessation of PD, or the end of the study (December 30, 2017). The utility of IL-6AR in predicting peritonitis-free survival was analyzed using the Kaplan-Meier and Cox proportional hazards models. <b><i>Results:</i></b> A total of 149 patients were enrolled, including 72 males (48%) with mean age 52.0 ± 13.6 years and median PD duration 26 (5.9–45.5) months. During follow-up, 7,923 patient months were observed and 154 episodes of peritonitis occurred in 82 patients. Previous peritonitis episodes were significantly associated with log dialysate IL-6AR levels (β = 0.187 [0.022–0.299], <i>p</i> = 0.023). Patients in the high IL-6AR group showed a significantly inferior peritonitis-free survival when compared with their counterparts in the low IL-6AR group (48.8 vs. 67.7 months, <i>p</i> = 0.026), as well as higher treatment failure percentage of peritonitis (20.3 vs. 9.3%, <i>p</i> = 0.049). A multivariate Cox regression showed that high dialysate IL-6AR (hazard ratio [HR] 1.247 [1.052–1.478]; <i>p</i> = 0.011) and high serum C-reactive protein (HR 1.072 [1.005–1.144]; <i>p</i> = 0.036) were independent risk factors for inferior peritonitis-free survival. <b><i>Conclusion:</i></b> This prospective study suggested that the intraperitoneal inflammation marker, dialysate IL-6 level, might be a potential predictor of peritonitis development in patients undergoing PD.
DOI: 10.6084/m9.figshare.6269048
title: Data for article "Assessing the temporal dynamics of aquatic and terrestrial litter decomposition in an alpine forest" published in FUNCTIONAL ECOLOGY by Yue et al. 2018

description: Details about the methods can be found in the corresponding article published in Functional Ecology. Any use of the data should be agreed by the authors by email at kyleyuechina@163.com.
DOI: 10.6084/m9.figshare.6269048.v1
title: Data for article "Assessing the temporal dynamics of aquatic and terrestrial litter decomposition in an alpine forest" published in FUNCTIONAL ECOLOGY by Yue et al. 2018

description: Details about the methods can be found in the corresponding article published in Functional Ecology. Any use of the data should be agreed by the authors by email at kyleyuechina@163.com.
DOI: 10.6084/m9.figshare.6269039
title: Supplementary Material for: Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

description: <b><i>Background:</i></b> Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. <b><i>Methods:</i></b><i></i> We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. <b><i>Results:</i></b> In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the <i>LDL receptor related protein 2</i> gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the <i>BCAS3</i> gene locus, and chr 18 with 3 variants including rs74183647 in the<i> nuclear factor of ­activated T-cells 1</i> gene locus) reached the suggestive level of <i>p</i> &lt; 1 × 10<sup>–6</sup> in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the <i>microsomal triglyceride transfer protein</i> gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of <i>p</i> &lt; 5 × 10<sup>–8</sup> in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. <b><i>Conclusion:</i></b> Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations.
DOI: 10.6084/m9.figshare.6269039.v1
title: Supplementary Material for: Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

description: <b><i>Background:</i></b> Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. <b><i>Methods:</i></b><i></i> We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. <b><i>Results:</i></b> In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the <i>LDL receptor related protein 2</i> gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the <i>BCAS3</i> gene locus, and chr 18 with 3 variants including rs74183647 in the<i> nuclear factor of ­activated T-cells 1</i> gene locus) reached the suggestive level of <i>p</i> &lt; 1 × 10<sup>–6</sup> in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the <i>microsomal triglyceride transfer protein</i> gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of <i>p</i> &lt; 5 × 10<sup>–8</sup> in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. <b><i>Conclusion:</i></b> Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations.
DOI: 10.6084/m9.figshare.6269024
title: ESC_LATERAL_GROW_REP_A

description: These are the original pictures of the ESC lateral grow experiment, for repetition A. Picture name (number) indicates time from experiment initiation.
DOI: 10.6084/m9.figshare.6269024.v4
title: ESC_LATERAL_GROW_REP_A

description: These are the original pictures of the ESC lateral grow experiment, for repetition A. Picture name (number) indicates time from experiment initiation.
DOI: 10.6084/m9.figshare.6269024.v3
title: ESC Lateral Grow

description: These are the original pictures of the ESC lateral grow experiment, for repetition A. Picture name (number) indicates time from experiment initiation.
DOI: 10.6084/m9.figshare.6269021
title: Supplementary Material for: Bidirectional Connections between Depression and Ataxia Severity in Spinocerebellar Ataxia Type 3 Patients

description: <b><i>Background:</i></b> Spinocerebellar ataxia type 3 (SCA3), which is the most common subtype of SCA worldwide, exhibits common neuropsychological symptoms such as depression. However, the contribution of depression to the severity of SCA3 has not yet been thoroughly investigated. <b><i>Methods:</i></b> The present study investigated the prevalence of depression using Beck depression inventory in 104 molecularly conﬁrmed SCA3 patients from China. The putative risk factors for depression and whether the depression could affect the severity of ataxia were established by multivariable linear regression models. <b><i>Results:</i></b> The frequency of depression in the study subjects was 57.69% (60/104), which was higher than that in SCA3 patients from a subset of other populations. The gender (<i>p</i> = 0.03) and severity (<i>p</i> &lt; 0.01) of ataxia were those risk factors that could affect depression. Conversely, depression (<i>p</i> &lt; 0.01) together with the duration (<i>p </i>&lt; 0.01) of SCA3 could also play a positive role in the severity of ataxia. <b><i>Conclusions:</i></b> The extremely common depression results from motor disability caused by ataxia; it also affects the disease severity of SCA3. These findings suggested that depression was a part of neurodegeneration in SCA3 and necessitated intensive focus and interventions while caring for SCA3 patients.
DOI: 10.6084/m9.figshare.6269015
title: Evaluation of the GeneXpert MTB/RIF in patients with presumptive tuberculous meningitis.

description: Clinical and CSF data of patients suspected with TB meningitis.
DOI: 10.6084/m9.figshare.6269015.v1
title: Evaluation of the GeneXpert MTB/RIF in patients with presumptive tuberculous meningitis.

description: Clinical and CSF data of patients suspected with TB meningitis.
DOI: 10.6084/m9.figshare.6269009
title: Supplementary Material for: Kidney Disease in Women is Associated with Disadvantaged Childhood Socioeconomic Position

description: <b><i>Background:</i></b> Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation. <b><i>Methods:</i></b> Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years. We defined childhood and adulthood SEP according to father’s and respondent’s occupation respectively. SEP was categorised as high (reference), intermediate, low and never worked. CKD was defined as a glomerular filtration rate &lt; 60 mL/min/1.73 m<sup>2</sup> estimated from the combination of creatinine and cystatin C. We used logistic regression to estimate the age-adjusted association between SEP and CKD separately in men and women. <b><i>Results:</i></b> Low childhood SEP was strongly associated with CKD in women, after adjusting for adulthood SEP (OR 1.90 [95% CI 1.24–2.92]), supporting the critical period hypothesis. This association was not explained by traditional CKD risk factors. Women who experienced low childhood SEP and whose circumstances improved in adulthood also had increased odds of CKD, further supporting a critical period effect in childhood. There was comparatively less evidence in support of the pathway or accumulation models. We did not observe a statistically significant association between SEP and CKD in men. <b><i>Conclusions:</i></b> Our findings suggest that women exposed to disadvantaged SEP in childhood represent an at-risk group in whom there may be opportunities for identification of CKD and facilitation of health-promoting behaviours from an early age.