cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5241082.v1
title: Erratum: Signaling Axis in Osteoclast Biology and Therapeutic Targeting in the RANKL/RANK/OPG System

description: Bone integrity is maintained through a balance between bone formation and bone resorption, and osteoclasts are primary cells involved in bone resorption. Recent studies have revealed an essential role of macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL) in the development of osteoclasts, and detailed molecular cascades that induce osteoclast differentiation, activation and apoptosis have been clarified. Osteoclasts are involved in various pathologic conditions, such as osteoporosis, rheumatoid arthritis and tumor-induced bone disease, which are characterized by abnormal bone resorption, and the finding of RANKL has provided us a good therapeutic target for such pathologic conditions.
DOI: 10.6084/m9.figshare.14703108.v3
title: Table 2. Characteristics of Included Reviews

description: Characteristics of Included Reviews<br>
DOI: 10.6084/m9.figshare.23056766.v1
title: High-throughput investigation on serum and saliva samples by Raman spectroscopy in patients with polycystic ovary syndrome and periodontitis

description: The present findings on the significant association of PCOS with periodontitis highlight the great need for regular periodontal screening and essential oral healthcare integration in the long-term management of patients with PCOS.
DOI: 10.6084/m9.figshare.24603600.v1
title: Supplementary Material for: Developing and validating a simple risk score for patients with acute myocardial infarction

description: Introduction: Mortality from acute myocardial infarction (AMI) remains substantial. The current study is aimed at developing a novel simple risk score for AMI.
Methods: The Coronary Artery Tree description and Lesion EvaluaTion (CatLet) extended validation trial (ChiCTR2000033730) and the CatLet validation trial (ChiCTR-POC-17013536), both being registered with chictr.org, served as the derivation and validation datasets, respectively. Both datasets included 1018 and 308 patients, respectively. They all suffered from AMI and underwent percutaneous intervention (PCI). The endpoint was 4-year all-cause death. Lasso regression analysis was used for covariate selection and coefficient estimation. 
Results: Of 26 candidate predictor variables, four strongest predictors for 4-year mortality were included in this novel risk score with an acronym of BACEF (serum alBumin, Age, serum Creatinine, and LVEF). This score was well calibrated and yielded an AUC (95%CI) statistics of 0.84(0.80-0.87) in internal validation, 0.89(0.83-0.95) in internal-external (temporal) validation, and 0.83(0.77-0.89) in external validation. Notably, it outperformed the ACEF, ACEFII, GRACE scores with respect to 4-year mortality prediction.
Conclusion: A simple risk score for 4-year mortality risk stratification was developed, extensively validated, and calibrated in patients with AMI. This novel BACEF score may be a useful risk stratification tool for patients with AMI.
DOI: 10.6084/m9.figshare.25942813.v1
title: Supplementary Material for: Results from the Delivery of a Community Health Worker Training to Advance Competencies in Cancer Genomics

description: Introduction: Less than half of eligible Black women are assessed for genetic risk and only 28% engage in recommended HBOC risk-reducing interventions. CHWs are trusted members of the community that work as a liaison between health systems and the community to improve access to services and support cancer prevention efforts, though they are an overlooked to support genetic risk assessment. To address the need and training gaps for CHWs we developed and assessed an online training program called KEEP IT (Keeping Each other Engaged Program via IT).
Methods: The curriculum and modules were developed through engaging a panel of experts in a three-round Delphi process. The process led to creation of 10 modules for the training. Recruitment focused on CHWs who worked in clinical settings or groups providing outreach or health services to Black women. Measures of the training were guided by the RE-AIM framework to evaluate the course and its effectiveness.
Results: 46 individuals expressed interest in the training after recruitment. 38 individuals were eligible for the training and 26 completed the course. We found improvements in knowledge and genomics competencies immediately post-course, but the majority of these improvements were not sustained at three-months follow up. The training was highly rated for its relevance to CHW work and overall delivery. Top rated sessions included Hereditary Breast and Ovarian Cancer and Family History and Family History Collection. On average, participants reported discussing HBOC with 17 individuals at three-months follow-up.
Discussion: Championing a diverse cancer and genomics workforce can help address the goals of the National Cancer Plan to improve early detection and health equity. Through this training, CHWs gained critical cancer and genomics knowledge that was then applied to their primary roles.
DOI: 10.6084/m9.figshare.7489646.v1
title: intonation perception dataset

description: This file contains the minimal data-set for the manuscript titled "Effect of F0 Contour on Perception of Mandarin Chinese Speech against Masking" which was submitted to journal PLOS ONE.<br>The design of the experiment is fully explained in the manuscript.
DOI: 10.6084/m9.figshare.5104846.v1
title: When moles became diggers: <i>Tegulariscaptor</i> gen. nov., from the early Oligocene of south Germany, and the evolution of talpid fossoriality

description: The systematics of <i>Geotrypus</i> is among the most debated within Talpidae, but the recent development of quantitative methods for shape analyses allows us to provide a thorough reconsideration of <i>Geotrypus</i> spp. In the present study, we perform a systematic revision of the species <i>Geotrypus minor</i> from the early Oligocene of Germany using two-dimensional geometric morphometrics on the humerus, and cladistic analyses using two different character matrices. Our results suggest a distinct generic allocation for this species based on its unique humeral shape. Cladistic analyses reveal that <i>G. minor</i> has closer phylogenetic relationships with urotrichine shrew-moles than with other <i>Geotrypus</i> species or highly fossorial moles. Quantitative methods applied in this study support qualitative observations and fully justify a new generic allocation. In light of these results, Tegulariscaptor gen. nov. is proposed to encompass the material previously assigned to <i>G. minor</i>. http://zoobank.org/urn:lsid:zoobank.org:pub:8A839F1E-0EC8-4799-B3AE-1A4E54A95F0E
DOI: 10.6084/m9.figshare.6396374.v1
title: Database Peripartum Fetal Distress Excel

description: Dataset Peripartum Fetal Distress in Diabetic Women
DOI: 10.6084/m9.figshare.21198064.v3
title: Crr and Intrapr. Article

description: -Ddbb with the variables used in the analyses -Stata sintax with the analyses
DOI: 10.6084/m9.figshare.28150856.v1
title: Data from: Effects of urbanisation, habitat characteristics, and management on garden pond biodiversity: Findings from a large-scale citizen science survey

description: Data from:Zsuzsanna Márton, Barta Barbara, Csaba F. Vad, Beáta Szabó, Andrew J. Hamer, Vivien Kardos, Csilla Laskai, Ádám Fierpasz, Zsófia Horváth (2025) Effects of urbanisation, habitat characteristics, and management on garden pond biodiversity: Findings from a large-scale citizen science survey. Landscape and Urban planning,
DOI: 10.6084/m9.figshare.5123755.v1
title: Supplementary Material for: Neuropeptide TLQP-21, a VGF Internal Fragment, Modulates Hormonal Gene Expression and Secretion in GH3 Cell Line

description: In the present study we demonstrated that TLQP-21, a biologically active peptide derived from the processing of the larger pro-VGF granin, plays a role in mammotrophic cell differentiation. We used an established in vitro model, the GH3 cell line, which upon treatment with epidermal growth factor develops a mammotrophic phenotype consisting of induction of prolactin expression and secretion, and inhibition of growth hormone. Here we determined for the first time that during mammotrophic differentiation, epidermal growth factor also induces Vgf gene expression and increases VGF protein precursor processing and peptide secretion. After this initial observation we set out to determine the specific role of the VGF encoded TLQP-21 peptide on this model. TLQP-21 induced a trophic effect on GH3 cells and increased prolactin expression and its own gene transcription without affecting growth hormone expression. TLQP-21 was also able to induce a significant rise of cytoplasmic calcium, as measured by Fura2AM, due to the release from a thapsigargin-sensitive store. TLQP-21-dependent rise in cytoplasmic calcium was, at least in part, dependent on the activation of phospholipase followed by phosphorylation of PKC and ERK. Taken together, the present results demonstrate that TLQP-21 contributes to differentiation of the GH3 cell line toward a mammotrophic phenotype and suggest that it may exert a neuroendocrine role in vivo on lactotroph cells in the pituitary gland.
DOI: 10.6084/m9.figshare.28020791.v1
title: 1.8 ng

description: This dataset was used to explore deep learning models ability to quantify analyte load of LFA. Commercially available COVID-19 Rapid test kits, which test for the presence of nucleocapsid(N) protein, were photographed with a smartphone after results were ready. During the testing a known amount of N protein was added to the extraction buffer tube after which the following steps were performed according to manufacturer's instructions. This dataset was used to train deep learning models to classify various levels of N protein.
DOI: 10.17632/3h6h5d7xg2
title: Russian Handwritings Tracked

description: We created a character dataset by collecting samples from 12 writers. Each writer contributed with letters (lower and uppercase), digits, and words from a pangram that we have not employed in our experiments, but they are included in "extra" folder for each writer in this database. Up to 4 samples have been collected for each pair writer/character, and the total number of samples in this database version is 2812.

Database structure:

scanner.py - character scanning program, dataset collection.
convert2mnist.py - a program for converting a dataset into a mnist-like form. It is intended for an example with the test.
example_using.py - example of a primitive grid for character recognition. It is intended only to demonstrate the consistency of the dataset. When using the dataset, of course, the user can and will use their own, more advanced approaches.
data - folder with dataset.
w_n_m - folder with writer's attempt (in total 37 folders)
  [char] - the main file of the symbol track, a text file with a list of coordinates of the form - "x1","y1","x2","y2",...,"xN","yN".
  [char]_times - a file with additional information on the track with a list of time in ms between receiving coordinates of points.
  [char].png is an auxiliary file - a picture of the symbol as it was visible to the writer. The file is for understanding only.

Class distribution in example_using.py, which you can find in github repository provided below:

[A] = { "а" , "А" }
[Б] = { "б" , "Б" }
[В] = { "в" , "В" }
[Г] = { "г" , "Г" }
[Д] = { "д" , "Д" }
[Е] = { "е" , "Е" }
[Ё] = { "ё" , "Ё" }
[Ж] = { "ж" , "Ж" }
[З] = { "з" , "З" }
[И] = { "и" , "И" }
[Й] = { "й" , "Й" }
[К] = { "к" , "К" }
[Л] = { "л" , "Л" }
[М] = { "м" , "М" }
[Н] = { "н" , "Н" }
[О] = { "о" , "О", "0" }
[П] = { "п" , "П" }
[Р] = { "р" , "Р" }
[С] = { "с" , "С" }
[Т] = { "т" , "Т" }
[У] = { "у" , "У" }
[Ф] = { "ф" , "Ф" }
[Х] = { "х" , "Х" }
[Ц] = { "ц" , "Ц" }
[Ч] = { "ч" , "Ч" }
[Ш] = { "ш" , "Ш" }
[Щ] = { "щ" , "Щ" }
[Ъ] = { "ъ" , "Ъ" }
[Ы] = { "ы" , "Ы" }
[Ь] = { "ь" , "Ь" }
[Э] = { "э" , "Э" }
[Ю] = { "ю" , "Ю" }
[Я] = { "я" , "Я" }
[1] = { "1" }
[2] = { "2" }
[3] = { "3" }
[4] = { "4" }
[5] = { "5" }
[6] = { "6" }
[7] = { "7" }
[8] = { "8" }
[9] = { "9" }
DOI: 10.15468/dl.uvfgrx
title: Occurrence Download

description: A dataset containing 666 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Ochropleura leucogaster Freyer"
 ]
}

 The dataset includes 666 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009378-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.23615427.v2
title: Raw data - Darwin Board LOG files (.csv)

description: Raw LOG file datasets (.csv) from 'Darwin Board' microcomputers.
DOI: 10.6084/m9.figshare.26292994.v1
title: Supplemental dataset

description: Datasets for individual data and OTUs
DOI: 10.6084/m9.figshare.28235789.v1
title: Viral Contigs Identified from marine picocyanobacteria cultures

description: This dataset contains viral contigs recovered from marine picocyanobacteria cultures. The data was generated using high-throughput sequencing technologies, including Illumina and Qitan nanopore sequencing, to identify and assemble viral sequences present in marine environments. The contigs provide valuable insights into the viral diversity and microbial interactions in these ecosystems. This data can help researchers study marine virology and the ecological roles of viruses in marine ecosystems.
DOI: 10.6084/m9.figshare.23551920.v1
title: Supplementary Material for: Assessing the clinical and endoscopic efficacy of extended duration treatment with different doses of mesalazine for mild to moderate ulcerative colitis beyond 8 weeks of induction

description: Introduction: High-strength mesalazine formulations play an important role in providing a convenient option to increase the dose in ulcerative colitis (UC) patients and therefore avoiding the switch to another therapeutic class. Higher doses of mesalazine may be required during periods of remission in order to prevent relapse. Aim: To investigate clinical outcomes of three mesalazine maintenance doses adapted for post induction response. Methods: In this post-hoc analysis, 675 UC patients entered an open label extension study for a total of 38 weeks (including 8-12 week induction period with 3.2 g/day mesalazine). After the induction period they were separated into three groups: remitters (in clinical and endoscopic remission), responders (decrease in Partial Mayo Clinic Score (PMCS) of ≥ 2 points and ≥ 30% from week 0) and non-responders (failed to achieve endoscopic and clinical response at week 8) and received 1.6 g/day, 3.2 g/day or 4.8 g/day of mesalazine (using a new 1600 mg mesalazine tablet), respectively. Results: 133/202 (65.8%), 108/274 (39.4%) and 59/199 (29.6%) patients achieved clinical and endoscopic remission at week 38 with 1.6 g/day, 3.2 g/day and 4.8 g/day, respectively. At week 38, 142/202 (70.3%), 93/274 (33.9%) and 61/199 (30.7%) patients achieved clinical remission (stool score of 0 and rectal bleeding score of 0) with 1.6 g/day, 3.2 g/day and 4.8 g/day, respectively. Conclusions: Patients partially responding or not responding to an initial induction dose of 3.2 g/day mesalazine could benefit from an extended treatment period at the same dose, or an increase to 4.8 g/day in an attempt to achieve combined clinical and endoscopic remission.
DOI: 10.6084/m9.figshare.25656444.v3
title: PRISMA CHECKLIST v2020 for 'Efficacy and safety of various drug combinations in treating plaque psoriasis: A meta analysis'

description: PRISMA checklist for the research article Efficacy and safety of various drug combinations in treating plaque Psoriasis: A Meta Analysis
DOI: 10.6084/m9.figshare.28503419.v1
title: Supplementary Material for: Streptococcus pyogenes activates human platelets via streptolysin S-mediated calcium ion influx

description: Introduction: Streptococcus pyogenes (group A streptococcus, GAS) is an exclusively human pathogen. It causes a wide spectrum of diseases, ranging from mild infections such as pharyngitis to severe life-threatening conditions such as streptococcal toxic shock syndrome (STSS). Thrombocytopenia is a common feature of STSS and is associated with severe outcome. GAS produce a plethora of virulence factors, including streptolysin S (SLS), which has lytic as well as immuno-modulatory properties. However, its role in platelet activation remains unclear.
Methods: Washed human platelets were infected with GAS wild-type and SLS-deficient mutant (ΔsagA) strains. Platelet activation was assessed by measuring degranulation (CD62P expression). The role of calcium influx and the involvement of purinergic type 2 receptors (P2R) in platelet activation by GAS were assessed using chemical antagonists and calcium chelators.
Results: GAS activate human platelets via SLS-mediated calcium influx, marked by increased surface expression of CD62P. IVIG treatment improved platelet viability in wild-type infections but failed to prevent SLS-mediated activation. Blocking of P2 receptors via suramin or NF449 as well as the use of calcium chelators reduced SLS-mediated platelet activation.
Conclusion: This study identified SLS as an M-protein and consequently serotype-independent activator of human platelets. While IVIG partially improved platelet viability in GAS infections, its inability to prevent excessive platelet activation underscores the need for additional treatment options in severe GAS infections.
DOI: 10.6084/m9.figshare.28553168.v1
title: Capolab_Yeh1

description: Capolab_Yeh1 pool: 16S-18S (Yeh et al. 2021) metabarcoding run for NOR24 water samples (P stations and time series). Tag combinations will be shared upon publication (two projects).
DOI: 10.6084/m9.figshare.28674134.v1
title: 原始data.zip

description: 非洲猪瘟 （ASF） 由非洲猪瘟病毒 （ASFV） 引起，是一种传染性很强的出血性疾病，对全球养猪业造成严重的社会经济影响。尽管为开发有效的控制策略做出了巨大努力，但 缺乏有效的体外模型仍然是一个关键障碍。一个关键挑战在于 ASFV 的趋向性受限;它强烈感染原代猪肺泡巨噬细胞 （PAM），并且在大多数传代细胞系中表现出较差的复制效果，阻碍了机制研究和抗病毒开发。为了解决这一限制，我们对感染早期 ASFV 感染的 PAM （原代细胞） 和 ZMAC-4 细胞 （传代巨噬细胞系） 进行了比较转录组学分析。我们的研究结果揭示了两种细胞类型之间病毒易感性和宿主反应的显着差异。转录组分析确定了关键途径的不同激活： ZMAC-4 细胞主要上调氧化应激相关途径，而 PAMs 表现出强大的细胞因子信号传导和免疫激活。通过敲低和过表达实验对差异表达基因 （DEGs） 的进一步分析表明，junctophilin-4 （JPH4） 和细胞色素 P450 1A1 （CYP1A1） 是两个潜在的宿主限制因子。本研究描述了 ASFV 允许细胞与半允许细胞中的早期宿主病毒动力学，提供了对趋向性的机制见解，并强调 JPH4/CYP1A1 是抗病毒策略的新靶点。这些发现为合理设计抗病毒策略和改进疫苗平台奠定了基础，从而解决了非洲猪瘟研究中的关键空白。
DOI: 10.6084/m9.figshare.28242155.v1
title: MDAMB436 Co-Cultures

description: Flow Cytometry Analysis
DOI: 10.6084/m9.figshare.12067401.v1
title: Code and summary results for: Analysis of electronic health records reveals medication-related interference on point-of-care urine drug screening assays

description: Zip file contains parameter and metadata files, sql and R scripts, and results in the form of figures and csv files.
DOI: 10.6084/m9.figshare.24153633.v2
title: Down-regulation of TGF-β1 in Fibro-adipogenic Progenitors Initiates Muscle Ectopic Mineralization

description: Supplementary materials for article Down-regulation of TGF-β1 in Fibro-adipogenic Progenitors Initiates Muscle Ectopic Mineralization.
DOI: 10.6084/m9.figshare.5573542.v1
title: FRET Simulation Dataset

description: Datafiles contain over 3 million simulated noisy FRET spectra which can be used for validating FRET analysis approaches. The same data is formatted for both matlab and python. The matlab file can be read in with each of the components as a separate variable. The python numpy array can be read in and then converted to a dictionary containing each component using numpy.load(‘YourFilepath’).item().<br>Matlab Variable/Python Dictionary Entry:<br> ’Simulated Pixels’: These are simulated noisy spectra covering a range of SNR and FRET efficiencies, organized in the following manner: Simulated_Pixels[N,Power,Efficiency,Excitation,Emission], where N are repeat simulations to calculate statistics with (1000 simulations for every condition). Has an overall shape of (1000, 150, 11, 2, 32). ’sRET luxFRET Calibration Spectra’: These are noiseless calibration spectra organized in the following manner: sRET luxFRET Calibration Spectra[Power,Donor or Acceptor,Excitation,Emission], with an overall shape of (150, 2, 2, 32). These spectra can also be used to calculate the normalized emission spectra and gamma parameter needed for sensorFRET, but we also included those values separately for convenience. ’Power Vector’: The vector relating the indices in the 2nd dimension of ‘Simulated Pixels’ to the simulated power used ranging from 0.1-1000 (arbitrary units) in 150 logarithmic steps to change the SNR and provide normalized residuals in the approximate range of 0.001 to 0.1. ’Efficiency Vector’: The vector relating the indices in the 3rd dimension of ‘Simulated Pixels’ to the simulated FRET efficiency ranging from 0 to 1 in 11 linear steps. ’Excitation Wavelength Vector’: The vector relating the indices of the 4th dimension of ‘Simulated Pixels’ to the simulated Excitation wavelength, either 405 or 458. ’Emission Wavelength Vector’: The vector relating the indices of the 5th dimension of ‘Simulated Pixels’ to the simulated Emission Wavelengths, ranging from 416 to 718 in 32 linear steps to match the spectral resolution of our experiments. ’Normalized Emission Spectra’:An array containing the normalized emission shapes for the Cerulean and Venus fluorophores (shape of (2, 32)). ’Gamma’: the sensorFRET gamma parameter for the Cerulean/Venus-405/458 pairing, 0.0605 (from experiment) ’Qd’: the quantum efficiency of Cerulean, 0.62.<br> ’Qa’: the quantum efficiency of Venus, 0.57.
DOI: 10.6084/m9.figshare.23290097.v1
title: V4 Microbiome Library (phyloseq)

description: V4 Microbiome Library (phyloseq)
DOI: 10.6084/m9.figshare.28331269.v1
title: Additional file 2 of Long-read 16S rRNA amplicon sequencing reveals microbial characteristics in patients with colorectal adenomas and carcinoma lesions in Egypt

description: Supplementary Material 2