cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4299389.v16
title: Long-Term Effects of Acute Stress on the Prefrontal-Limbic System in the Healthy Adult

description: Most
people are exposed to at least one traumatic event during the course of their lives, but large numbers of people do not develop
posttraumatic stress disorders. Although previous studies have shown that
repeated and chronic stress change the brain’s structure and function, few
studies have focused on the long-term
effects of acute
stressful exposure in a nonclinical sample,
especially the morphology and functional connectivity changes in brain regions
implicated in emotional reactivity and emotion regulation. Forty-one months
after the 5/12 Wenchuan earthquake, we investigated the effects of trauma exposure
on the structure and functional connectivity of the brains of trauma-exposed
healthy individuals compared with healthy controls matched for age, sex, and
education. We then used machine-learning algorithms with the brain structural
features to distinguish between the two groups at an individual level. In the trauma-exposed
healthy individuals, our results showed greater gray matter density in
prefrontal-limbic brain systems, including the dorsal anterior cingulate
cortex, medial prefrontal cortex, amygdala
and hippocampus, than in the controls. Further analysis showed stronger
amygdala-hippocampus functional connectivity in the trauma-exposed healthy
compared to the controls. Our findings revealed that survival of traumatic experiences, without developing
PTSD, was associated with greater gray matter density in the prefrontal-limbic
systems related to emotional regulation.
DOI: 10.6084/m9.figshare.4299389.v17
title: Long-Term Effects of Acute Stress on the Prefrontal-Limbic System in the Healthy Adult

description: Most
people are exposed to at least one traumatic event during the course of their lives, but large numbers of people do not develop
posttraumatic stress disorders. Although previous studies have shown that
repeated and chronic stress change the brain’s structure and function, few
studies have focused on the long-term
effects of acute
stressful exposure in a nonclinical sample,
especially the morphology and functional connectivity changes in brain regions
implicated in emotional reactivity and emotion regulation. Forty-one months
after the 5/12 Wenchuan earthquake, we investigated the effects of trauma exposure
on the structure and functional connectivity of the brains of trauma-exposed
healthy individuals compared with healthy controls matched for age, sex, and
education. We then used machine-learning algorithms with the brain structural
features to distinguish between the two groups at an individual level. In the trauma-exposed
healthy individuals, our results showed greater gray matter density in
prefrontal-limbic brain systems, including the dorsal anterior cingulate
cortex, medial prefrontal cortex, amygdala
and hippocampus, than in the controls. Further analysis showed stronger
amygdala-hippocampus functional connectivity in the trauma-exposed healthy
compared to the controls. Our findings revealed that survival of traumatic experiences, without developing
PTSD, was associated with greater gray matter density in the prefrontal-limbic
systems related to emotional regulation.
DOI: 10.5519/qd.53hdwlvu
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.6084/m9.figshare.4299671
title: The thermo-mechanical response of PP nanocomposites at high graphene loading

description: Authors have successfully fabricated polypropylene/graphene nanoplatelets (PP/GNPs), nanocomposites that are thermally conductive, processable, and flame resistant. Thermal conductivity measurements indicated that the thermal coefficient scaled linearly with GNP loading, where a value of 2.0 W m<sup>− 1</sup> K<sup>− 1</sup> was achieved at 40 wt-% loading. Tensile measurements indicated that the modulus increased linearly with GNP loading, while the Izod impact, after an initial decrease, remained constant for loadings up to 50 wt-%. Small angle X-ray scattering (SAXS) showed a large decrease in the amount of lamellar structure relative to the neat PP, while wide angle X-ray scattering (WAXS) showed a high degree of crystallinity. These results are consistent with formation of a new type of layered nanocomposite, composed of crystalline PP chains oriented onto layered GNPs.
DOI: 10.6084/m9.figshare.4299671.v1
title: The thermo-mechanical response of PP nanocomposites at high graphene loading

description: Authors have successfully fabricated polypropylene/graphene nanoplatelets (PP/GNPs), nanocomposites that are thermally conductive, processable, and flame resistant. Thermal conductivity measurements indicated that the thermal coefficient scaled linearly with GNP loading, where a value of 2.0 W m<sup>− 1</sup> K<sup>− 1</sup> was achieved at 40 wt-% loading. Tensile measurements indicated that the modulus increased linearly with GNP loading, while the Izod impact, after an initial decrease, remained constant for loadings up to 50 wt-%. Small angle X-ray scattering (SAXS) showed a large decrease in the amount of lamellar structure relative to the neat PP, while wide angle X-ray scattering (WAXS) showed a high degree of crystallinity. These results are consistent with formation of a new type of layered nanocomposite, composed of crystalline PP chains oriented onto layered GNPs.
DOI: 10.6084/m9.figshare.4299731.v1
title: TIMP1 promotes multi-walled carbon nanotube-induced lung fibrosis by stimulating fibroblast activation and proliferation

description: Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may cause fibrosing lesions in animal lungs, raising health concerns about such exposure in humans. The mechanisms underlying fibrosis development remain unclear, but they are believed to involve the dysfunction of fibroblasts and myofibroblasts. Using a mouse model of MWCNT exposure, we found that the tissue inhibitor of metalloproteinase 1 (Timp1) gene was rapidly and highly induced in the lungs by MWCNTs in a time- and dose-dependent manner. Concomitantly, a pronounced elevation of secreted TIMP1 was observed in the bronchoalveolar lavage (BAL) fluid and serum. Knockout (KO) of Timp1 in mice caused a significant reduction in fibrotic focus formation, collagen fiber deposition, recruitment of fibroblasts and differentiation of fibroblasts into myofibroblasts in the lungs, indicating that TIMP1 plays a critical role in the pulmonary fibrotic response to MWCNTs. At the molecular level, MWCNT exposure significantly increased the expression of the cell proliferation markers Ki-67 and PCNA and a panel of cell cycle-controlling genes in the lungs in a TIMP1-dependent manner. MWCNT-stimulated cell proliferation was most prominent in fibroblasts but not myofibroblasts. Furthermore, MWCNTs elicited a significant induction of CD63 and integrin β1 in lung fibroblasts, leading to the formation of a TIMP1/CD63/integrin β1 complex on the surface of fibroblasts <i>in vivo</i> and <i>in vitro</i>, which triggered the phosphorylation and activation of Erk1/2. Our study uncovers a new pathway through which induced TIMP1 critically modulates the pulmonary fibrotic response to MWCNTs by promoting fibroblast activation and proliferation via the TIMP1/CD63/integrin β1 axis and ERK signaling.
DOI: 10.6084/m9.figshare.4299731
title: TIMP1 promotes multi-walled carbon nanotube-induced lung fibrosis by stimulating fibroblast activation and proliferation

description: Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may cause fibrosing lesions in animal lungs, raising health concerns about such exposure in humans. The mechanisms underlying fibrosis development remain unclear, but they are believed to involve the dysfunction of fibroblasts and myofibroblasts. Using a mouse model of MWCNT exposure, we found that the tissue inhibitor of metalloproteinase 1 (Timp1) gene was rapidly and highly induced in the lungs by MWCNTs in a time- and dose-dependent manner. Concomitantly, a pronounced elevation of secreted TIMP1 was observed in the bronchoalveolar lavage (BAL) fluid and serum. Knockout (KO) of Timp1 in mice caused a significant reduction in fibrotic focus formation, collagen fiber deposition, recruitment of fibroblasts and differentiation of fibroblasts into myofibroblasts in the lungs, indicating that TIMP1 plays a critical role in the pulmonary fibrotic response to MWCNTs. At the molecular level, MWCNT exposure significantly increased the expression of the cell proliferation markers Ki-67 and PCNA and a panel of cell cycle-controlling genes in the lungs in a TIMP1-dependent manner. MWCNT-stimulated cell proliferation was most prominent in fibroblasts but not myofibroblasts. Furthermore, MWCNTs elicited a significant induction of CD63 and integrin β1 in lung fibroblasts, leading to the formation of a TIMP1/CD63/integrin β1 complex on the surface of fibroblasts <i>in vivo</i> and <i>in vitro</i>, which triggered the phosphorylation and activation of Erk1/2. Our study uncovers a new pathway through which induced TIMP1 critically modulates the pulmonary fibrotic response to MWCNTs by promoting fibroblast activation and proliferation via the TIMP1/CD63/integrin β1 axis and ERK signaling.
DOI: 10.6084/m9.figshare.4308932
title: Neoproterozoic alkaline intrusive complex in the northwestern Yangtze Block, Micang Mountains region, South China: petrogenesis and tectonic significance

description: Voluminous Neoproterozoic mafic–ultramafic, felsic, and alkaline intrusions are found in the northern Yangtze Block, South China. Here, we present whole-rock major and trace element, and Sr–Nd isotopic compositions, together with zircon U–Pb ages, for syenite and gabbro samples from the Shuimo–Zhongziyuan alkaline intrusive complex in the Micang Mountains region at the northwestern margin of the Yangtze Block. Zircon U–Pb dating yields crystallization ages for the Na- and K-rich Shuimo syenites of 869 ± 4 (MSWD = 0.85, 2<i>σ</i>) and 860 ± 5 Ma (MSWD = 0.47, 2<i>σ</i>), respectively, and for the Zhongziyuan gabbros of 753 ± 4 Ma (MSWD = 0.23, 2<i>σ</i>), indicating that the syenites and gabbros represent different stages of magmatism. The syenites include both Na- and K-rich types and have high values of the Rittman index (<i>σ</i>), and high SiO<sub>2</sub> and Na<sub>2</sub>O + K<sub>2</sub>O contents. These syenites are enriched in light rare earth elements (LREE) and large-ion lithophile elements (LILE), but depleted in high-field-strength elements (HFSE), with high (La/Yb)<sub>N</sub> values and small negative and positive Eu anomalies (Eu/Eu* = 0.74–1.17). In contrast, the gabbros have lower SiO<sub>2</sub> and Na<sub>2</sub>O + K<sub>2</sub>O contents, are only slightly enriched in LREEs, are enriched in LILE but depleted in HFSEs, and have small negative and positive Eu anomalies (Eu/Eu* = 0.86–1.37). The syenites have low initial <sup>87</sup>Sr/<sup>86</sup>Sr (0.703340) and <i>ɛ</i><sub>Nd</sub>(<i>t</i>) values (+1.9 to +7.7). The gabbros have relatively high initial <sup>87</sup>Sr/<sup>86</sup>Sr (0.703562–0.704933) and positive <i>ɛ</i><sub>Nd</sub>(<i>t</i>) values (+1.6 to +4.5). These data suggest that the syenites and gabbros are isotopically similar and were largely derived from melts of depleted mantle. The syenites underwent significant fractional crystallization and small amounts of crustal contamination during magma evolution. In contrast, the gabbros were formed by partial melting (&gt;15%) of a garnet lherzolite source and might also have experienced crustal assimilation. Taking into account the geochemical signatures and magmatic events, we propose that the Shuimo syenites formed in an intra-arc rifting setting, however, the Zhongziyuan gabbros were most likely produced in a subduction-related, continental margin arc setting during the Neoproterozoic, thus suggesting that the alkaline intrusive complex were formed by the arc-related magmatism in the Micang Mountains.
DOI: 10.6084/m9.figshare.4308932.v1
title: Neoproterozoic alkaline intrusive complex in the northwestern Yangtze Block, Micang Mountains region, South China: petrogenesis and tectonic significance

description: Voluminous Neoproterozoic mafic–ultramafic, felsic, and alkaline intrusions are found in the northern Yangtze Block, South China. Here, we present whole-rock major and trace element, and Sr–Nd isotopic compositions, together with zircon U–Pb ages, for syenite and gabbro samples from the Shuimo–Zhongziyuan alkaline intrusive complex in the Micang Mountains region at the northwestern margin of the Yangtze Block. Zircon U–Pb dating yields crystallization ages for the Na- and K-rich Shuimo syenites of 869 ± 4 (MSWD = 0.85, 2<i>σ</i>) and 860 ± 5 Ma (MSWD = 0.47, 2<i>σ</i>), respectively, and for the Zhongziyuan gabbros of 753 ± 4 Ma (MSWD = 0.23, 2<i>σ</i>), indicating that the syenites and gabbros represent different stages of magmatism. The syenites include both Na- and K-rich types and have high values of the Rittman index (<i>σ</i>), and high SiO<sub>2</sub> and Na<sub>2</sub>O + K<sub>2</sub>O contents. These syenites are enriched in light rare earth elements (LREE) and large-ion lithophile elements (LILE), but depleted in high-field-strength elements (HFSE), with high (La/Yb)<sub>N</sub> values and small negative and positive Eu anomalies (Eu/Eu* = 0.74–1.17). In contrast, the gabbros have lower SiO<sub>2</sub> and Na<sub>2</sub>O + K<sub>2</sub>O contents, are only slightly enriched in LREEs, are enriched in LILE but depleted in HFSEs, and have small negative and positive Eu anomalies (Eu/Eu* = 0.86–1.37). The syenites have low initial <sup>87</sup>Sr/<sup>86</sup>Sr (0.703340) and <i>ɛ</i><sub>Nd</sub>(<i>t</i>) values (+1.9 to +7.7). The gabbros have relatively high initial <sup>87</sup>Sr/<sup>86</sup>Sr (0.703562–0.704933) and positive <i>ɛ</i><sub>Nd</sub>(<i>t</i>) values (+1.6 to +4.5). These data suggest that the syenites and gabbros are isotopically similar and were largely derived from melts of depleted mantle. The syenites underwent significant fractional crystallization and small amounts of crustal contamination during magma evolution. In contrast, the gabbros were formed by partial melting (&gt;15%) of a garnet lherzolite source and might also have experienced crustal assimilation. Taking into account the geochemical signatures and magmatic events, we propose that the Shuimo syenites formed in an intra-arc rifting setting, however, the Zhongziyuan gabbros were most likely produced in a subduction-related, continental margin arc setting during the Neoproterozoic, thus suggesting that the alkaline intrusive complex were formed by the arc-related magmatism in the Micang Mountains.
DOI: 10.5281/zenodo.10866016
title: tricuspidalestes_caeruleus_zanfona_1.fasta.gz

description: .
DOI: 10.5281/zenodo.10866017
title: tricuspidalestes_caeruleus_zanfona_1.fasta.gz

description: .
DOI: 10.6084/m9.figshare.4315691
title: Divergent functions of <i>SNAC4–9</i> and possible mechanisms for tomato adaptation to abiotic stresses

description: Plants are exposed to all types of abiotic stresses during the process of growth and development, which could adversely affect the productivity and postharvest storage quality of plants. In the current study, the expression of <i>SNAC4–9</i> and the changes of physiological parameters were analyzed in tomato seedlings under various abiotic conditions and hormone treatments. The results demonstrate that all six genes were induced by these stresses at differential induction levels and that <i>SNAC4–9</i> gene expression profiles were likely to be related to the ABA, SA, and MeJA signaling pathways. In addition, all of the stress- and hormone-treated seedlings exhibited significant increases in their proline content and antioxidant enzyme activities. MDA was significantly increased in seedlings exposed to stress and decreased in hormone-treated seedlings. These data collectively suggest that SNAC4–9 might function through ABA, SA, and JA signaling pathways and the regulation of proline and antioxidant systems. This study combines molecular biology and physiology to provide valuable information for further exploring the functional roles of <i>NAC</i> genes in response to environmental stresses and indicates that these genes may exhibit potential for enhancing stress tolerance of transgenic tomato plants and further improving the postharvest storage quality of tomato plants.
DOI: 10.6084/m9.figshare.4315691.v1
title: Divergent functions of <i>SNAC4–9</i> and possible mechanisms for tomato adaptation to abiotic stresses

description: Plants are exposed to all types of abiotic stresses during the process of growth and development, which could adversely affect the productivity and postharvest storage quality of plants. In the current study, the expression of <i>SNAC4–9</i> and the changes of physiological parameters were analyzed in tomato seedlings under various abiotic conditions and hormone treatments. The results demonstrate that all six genes were induced by these stresses at differential induction levels and that <i>SNAC4–9</i> gene expression profiles were likely to be related to the ABA, SA, and MeJA signaling pathways. In addition, all of the stress- and hormone-treated seedlings exhibited significant increases in their proline content and antioxidant enzyme activities. MDA was significantly increased in seedlings exposed to stress and decreased in hormone-treated seedlings. These data collectively suggest that SNAC4–9 might function through ABA, SA, and JA signaling pathways and the regulation of proline and antioxidant systems. This study combines molecular biology and physiology to provide valuable information for further exploring the functional roles of <i>NAC</i> genes in response to environmental stresses and indicates that these genes may exhibit potential for enhancing stress tolerance of transgenic tomato plants and further improving the postharvest storage quality of tomato plants.
DOI: 10.6084/m9.figshare.4315694
title: Molecular cloning and functional analysis of a flavanone 3-hydroxylase gene from blueberry

description: <i>Vaccinium corymbosum</i> (blueberry) is touted as a superfood with numerous health benefits due to its high levels of flavonoids. Flavanone 3-hydroxylase (F3H) is a key regulatory enzyme of the flavonoid pathway. In this study, we cloned the full-length cDNA of <i>F3H</i> (designated <i>VcF3H</i>) from young blueberry leaves using rapid amplification of cDNA ends (RACE). The cDNA contained a 1080-bp open reading frame that encoded a 359-amino acid protein. The deduced VcF3H protein showed high similarities to other plant F3Hs. Conserved amino acid motifs required for ferrous iron binding (HXD) and 2-oxoglutarate binding (RXS) were identified in VcF3H, VcFLS (flavonol synthase), and VcANS (anthocyanidin synthase). Quantitative RT-PCR analysis demonstrated that <i>VcF3H</i> was expressed in all tissues tested, with particularly high expression in young leaves, fruits (pink and blue), and stems. Anthocyanins accumulated mainly in fruits, whereas flavonols were found mainly in leaves and stems. Furthermore, the expression pattern of <i>VcF3H</i> was similar to that of <i>VcCHS</i>, <i>VcDFR</i>, and <i>VcANS</i> in various tissues. Heterologous expression of <i>VcF3H</i> in <i>Arabidopsis thaliana</i> increased the anthocyanin content in leaves, but did not affect the flavonol content. Thus, <i>VcF3H</i> seems to be involved in anthocyanin synthesis in the flavonoid biosynthetic pathway when ectopically expressed in <i>Arabidopsis</i>.
DOI: 10.6084/m9.figshare.4315694.v1
title: Molecular cloning and functional analysis of a flavanone 3-hydroxylase gene from blueberry

description: <i>Vaccinium corymbosum</i> (blueberry) is touted as a superfood with numerous health benefits due to its high levels of flavonoids. Flavanone 3-hydroxylase (F3H) is a key regulatory enzyme of the flavonoid pathway. In this study, we cloned the full-length cDNA of <i>F3H</i> (designated <i>VcF3H</i>) from young blueberry leaves using rapid amplification of cDNA ends (RACE). The cDNA contained a 1080-bp open reading frame that encoded a 359-amino acid protein. The deduced VcF3H protein showed high similarities to other plant F3Hs. Conserved amino acid motifs required for ferrous iron binding (HXD) and 2-oxoglutarate binding (RXS) were identified in VcF3H, VcFLS (flavonol synthase), and VcANS (anthocyanidin synthase). Quantitative RT-PCR analysis demonstrated that <i>VcF3H</i> was expressed in all tissues tested, with particularly high expression in young leaves, fruits (pink and blue), and stems. Anthocyanins accumulated mainly in fruits, whereas flavonols were found mainly in leaves and stems. Furthermore, the expression pattern of <i>VcF3H</i> was similar to that of <i>VcCHS</i>, <i>VcDFR</i>, and <i>VcANS</i> in various tissues. Heterologous expression of <i>VcF3H</i> in <i>Arabidopsis thaliana</i> increased the anthocyanin content in leaves, but did not affect the flavonol content. Thus, <i>VcF3H</i> seems to be involved in anthocyanin synthesis in the flavonoid biosynthetic pathway when ectopically expressed in <i>Arabidopsis</i>.
DOI: 10.5281/zenodo.7554683
title: Data for paper "The Effect of Energetic Ion Dispersionless Injections on the Ring Current Dynamics"

description: The injection list and processed statistical data of paper "The Effect of Energetic Ion Dispersionless Injections on the Ring Current Dynamics.
DOI: 10.5281/zenodo.7554684
title: Data for paper "The Effect of Energetic Ion Dispersionless Injections on the Ring Current Dynamics"

description: The injection list and processed statistical data of paper "The Effect of Energetic Ion Dispersionless Injections on the Ring Current Dynamics.
DOI: 10.6084/m9.figshare.25466917
title: Importance scores of regulatory nucleotides in maize (calculated by occlusion)

description: The importance score of each nucleotide in the transcriptional regulatory region of each gene in maize was evaluated by the PhytoExpr model.
DOI: 10.6084/m9.figshare.25466917.v1
title: Importance scores of regulatory nucleotides in maize (calculated by occlusion)

description: The importance score of each nucleotide in the transcriptional regulatory region of each gene in maize was evaluated by the PhytoExpr model.
DOI: 10.5281/zenodo.10845068
title: Participatory Design Materials: Co-designing Child-Robot Relational Norm Intervention to Regulate Children's Handwriting Posture
DOI: 10.5281/zenodo.10845067
title: Participatory Design Materials: Co-designing Child-Robot Relational Norm Intervention to Regulate Children's Handwriting Posture
DOI: 10.5281/zenodo.10866022
title: Participatory Design Materials: Co-designing Child-Robot Relational Norm Intervention to Regulate Children's Handwriting Posture
DOI: 10.6084/m9.figshare.24910674.v1
title: Supplemenary for "Earth-Moon Dynamics from Cyclostratigraphy Reveals Possible Ocean Tide Resonance in the Mesoproterozoic Era"

description: Supplementary Materials forEarth-Moon Dynamics from Cyclostratigraphy Reveals Possible Oceanic Resonance in the Mesoproterozoic Era<br>