cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7942172
title: Health care are associated with worsening of frailty in community older adults

description: ABSTRACT OBJECTIVE To identify the factors associated with the worsening of frailty in older adults resident in the community. METHODS This is a prospective, longitudinal, and analytical study. The data collection in the baseline occurred in the participants’ homes from a random sampling by conglomerates. Demographic and socioeconomic variables, morbidities, and use of health services were analyzed. Frailty was measured by the Edmonton Frail Scale. The second data collection was performed after an average period of 42 months. The adjusted prevalence ratios were obtained by multiple Poisson regression analysis with robust variance. RESULTS A total of 394 older adults participated in both phases of the study, with 21.8% of them presenting worsening of the frailty condition. The variables that remained statistically associated with the transition to a worse state of frailty were: polypharmacy, negative self-perception of health, weight loss, and hospitalization over the past 12 months. CONCLUSIONS The factors associated with worsening of frailty along the studied period among older adults in the community were those related to health care. This result must be considered by health professionals when addressing frail and vulnerable older adults.
DOI: 10.6084/m9.figshare.7942184.v1
title: Galantamine protects against lipopolysaccharide-induced acute lung injury in rats

description: Lipopolysaccharide (LPS)-induced endotoxemia triggers the secretion of proinflammatory cytokines and can cause acute lung injury (ALI). The high mobility group box 1 (HMGB1) protein plays an important role as a late mediator of sepsis and ALI. Galantamine (GAL) is a central acetylcholinesterase inhibitor that inhibits the expression of HMGB1. This study evaluated the effects of GAL by measuring levels of inflammatory mediators and observing histopathological features associated with LPS-induced ALI. Sixty 8-10 week old male Sprague-Dawley rats (200-240 g) were randomized into three groups as follows: control group, LPS group (7.5 mg/kg LPS), and LPS+GAL group (5 mg/kg GAL before LPS administration). Histopathological examination of lung specimens obtained 12 h after LPS administration was performed to analyze changes in wet-to-dry (W/D) weight ratio, myeloperoxidase (MPO) activity, and HMGB1 expression level. Additionally, plasma concentrations of tumor necrosis factor-α, interleukin-6, and HMGB1 were measured using an enzyme-linked immunosorbent assay at 0 (baseline), 3, 6, 9, and 12 h after LPS administration. Mortality in the three groups was recorded at 72 h. LPS-induced ALI was characterized by distortion of pulmonary architecture and elevation of MPO activity, W/D weight ratio, and levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-6, and HMGB1. Pretreatment with GAL significantly reduced the LPS-induced lung pathological changes, W/D weight ratio, levels of pro-inflammatory cytokines and MPO activity (ANOVA). Moreover, GAL treatment significantly decreased the mortality rate (ANOVA). In conclusion, we demonstrated that GAL exerted a protective effect on LPS-induced ALI in rats.
DOI: 10.6084/m9.figshare.7942160
title: Particles panels prepared from dendê mesocarp as an alternative to MDF used in civil construction

description: ABSTRACT The lack of forest resources integrated with the need of purchasing more environmentally friendly products requires the use of other types of biomass besides wood in the construction sector. Therefore, the dendê mesocarp - waste arising from the agro-industry and with great use potential in developing new materials - is an alternative in the preparation of lignocellulosic panels to replace MDF (Medium Density Fiberboard), that is conventionally used. Thus, this work demonstrated the feasibility of the production and the structural integrity of this type of panel in the manufacture of building blocks to be used in civil construction through a comparative study of their properties with the MDF panels. The methodology consists in performing characterization tests in panels through determining their physical (water absorption, swelling and density) and mechanical (flexion resistance and modulus of elasticity) properties, besides analysing the morphology of the panels produced by the Scanning Electron Microscopy (MEV) technique, performing a chemical (via infrared spectrum Fourier transform) and thermal analysis through derived thermogravimetric curves. The results obtained suggest that the production of these panels without a binder, obtained by the incorporation of dendê mesocarp, adds value to the production chain of dendê, in addition to emerge as an alternative to the challenges inherent to the traditional production of wood panels and, consequently, is considered as an option of a constructive element to be integrated with the construction.
DOI: 10.6084/m9.figshare.7942163
title: Assessment of the diagnostic value of diffusion tensor imaging in patients with spinal cord compression: a meta-analysis

description: We investigated the diagnostic value of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of magnetic resonance diffusion tensor imaging (DTI) in patients with spinal cord compression (SCC) using a meta-analysis framework. Multiple scientific literature databases were exhaustively searched to identify articles relevant to this study. Mean values and standardized mean differences (SMDs) were calculated for the ADC and FA in normal and diseased tissues. The STATA version 12.0 software was used for statistical analysis. Of the 41 articles initially retrieved through database searches, 11 case-control studies were eligible for the meta-analysis and contained a combined total of 645 human subjects (394 patients with SCC and 251 healthy controls). All 11 studies reported data on FA, and 9 contained data related to the ADC. The combined SMDs of the ADC and FA showed that the ADC was significantly higher and the FA was lower in patients with SCC than in healthy controls. Subgroup analysis based on the b value showed higher ADCs in patients with SCC than in healthy controls at b values of both ≤500 and &gt;500 s/mm2. In summary, the main findings of this meta-analysis revealed an increased ADC and decreased FA in patients with SCC, indicating that DTI is an important diagnostic imaging tool to assess patients suspected to have SCC.
DOI: 10.6084/m9.figshare.7942166.v1
title: Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses

description: Physical exercise triggers coordinated physiological responses to meet the augmented metabolic demand of contracting muscles. To provide adequate responses, the brain must receive sensory information about the physiological status of peripheral tissues and organs, such as changes in osmolality, temperature and pH. Most of the receptors involved in these afferent pathways express ion channels, including transient receptor potential (TRP) channels, which are usually activated by more than one type of stimulus and are therefore considered polymodal receptors. Among these TRP channels, the TRPV1 channel (transient receptor potential vanilloid type 1 or capsaicin receptor) has well-documented functions in the modulation of pain sensation and thermoregulatory responses. However, the TRPV1 channel is also expressed in non-neural tissues, suggesting that this channel may perform a broad range of functions. In this review, we first present a brief overview of the available tools for studying the physiological roles of the TRPV1 channel. Then, we present the relationship between the TRPV1 channel and spontaneous locomotor activity, physical performance, and modulation of several physiological responses, including water and electrolyte balance, muscle hypertrophy, and metabolic, cardiovascular, gastrointestinal, and inflammatory responses. Altogether, the data presented herein indicate that the TPRV1 channel modulates many physiological functions other than nociception and thermoregulation. In addition, these data open new possibilities for investigating the role of this channel in the acute effects induced by a single bout of physical exercise and in the chronic effects induced by physical training.
DOI: 10.6084/m9.figshare.7942169.v1
title: Is a contrast study really necessary prior to ureteroscopy?

description: This study aimed to evaluate the effect of preoperative imaging techniques on the success and complication rates of ureteroscopy. We performed a retrospective analysis of 736 patients (455 males and 281 females), with a mean age of 45.5±15.2 years (range, 1-88 years), who underwent rigid ureteroscopic procedures for removal of ureteral stones. Patients were divided into 4 groups according to the type of imaging modality used: group I, intravenous urography (n=116); group II, computed tomography (n=381); group III, computed tomography and intravenous urography (n=91), and group IV, ultrasonography and abdominal plain film (n=148). Patients’ demographics, stone size and location, prior shock wave lithotripsy, lithotripsy technique, operation time, success rate, and rate of intraoperative complications were compared among the groups. There were no significant differences in success and complication rates among the groups. The stone-free rate after primary ureteroscopy was 87.1% in group I, 88.2% in group II, 96.7% in group III, and 89.9% in group IV (P=0.093). The overall incidence of intraoperative complications was 11.8%. According to the modified Satava classification system, 6.1% of patients had grade 1, 5.1% had grade 2, and 0.54% had grade 3 complications. Intraoperative complications developed in 12.1% of patients in group I, 12.6% of patients in group II, 7.7% of patients in group III, and 12.2% of patients in group IV (P=0.625). Our findings clearly demonstrate that ureteroscopic treatment of ureteral stones can be safely and effectively performed with no use of contrast study imaging, except in doubtful cases of anatomical abnormalities.
DOI: 10.6084/m9.figshare.7942172.v1
title: Health care are associated with worsening of frailty in community older adults

description: ABSTRACT OBJECTIVE To identify the factors associated with the worsening of frailty in older adults resident in the community. METHODS This is a prospective, longitudinal, and analytical study. The data collection in the baseline occurred in the participants’ homes from a random sampling by conglomerates. Demographic and socioeconomic variables, morbidities, and use of health services were analyzed. Frailty was measured by the Edmonton Frail Scale. The second data collection was performed after an average period of 42 months. The adjusted prevalence ratios were obtained by multiple Poisson regression analysis with robust variance. RESULTS A total of 394 older adults participated in both phases of the study, with 21.8% of them presenting worsening of the frailty condition. The variables that remained statistically associated with the transition to a worse state of frailty were: polypharmacy, negative self-perception of health, weight loss, and hospitalization over the past 12 months. CONCLUSIONS The factors associated with worsening of frailty along the studied period among older adults in the community were those related to health care. This result must be considered by health professionals when addressing frail and vulnerable older adults.
DOI: 10.6084/m9.figshare.7942151
title: Mathematical Intradisciplinarity with GeoGebra in School Mathematics

description: Abstract In this paper, we discuss the intradisciplinary work in school mathematics and bring evidences that the use of GeoGebra favors it. In order to do so, we question the process of disciplining science that contributed to the deepening of various areas, at the same time as it propelled a growing dissociation among them. Similarly, the hyper-specialization of mathematical knowledge has contributed to the fragmentation of school mathematics in the arithmetic, geometry, and algebra ramifications, which has made it difficult to learn by the students. Seeking the balance between fragmentation and totalization, we investigated the intradisciplinarity of school mathematics with GeoGebra. We used a qualitative research methodology and we analyzed an activity of proportional reasoning exploration developed with mathematics teachers from an elementary school. The analysis indicate that GeoGebra allows for the exploration of multiple representations that highlight particularities of the mathematical fronts through its diverse resources and windows that present the dynamically connected mathematical objects, which contributes in a way that the disadvantages of each representation are satisfied by the advantages of the others in teaching and learning mathematics. We concluded that the intradisciplinary mathematical approach with GeoGebra emphasizes the concomitant work among the different mathematical ramifications and offers the teachers the possibility of exploring it in their pedagogical practice.
DOI: 10.6084/m9.figshare.7942154
title: Personality traits and psychiatric comorbidities in alcohol dependence

description: Non-adaptive personality traits may constitute risk factors for development of psychiatric disorders such as depression and anxiety. We aim to evaluate associations and the predictive value of personality traits among alcohol-dependent individuals, with or without psychiatric comorbidities. The convenience sample comprised two groups of males over 18 years of age: one with subjects who had an alcohol dependence diagnosis (AG, n=110), and a control group without abuse and/or alcohol dependence diagnosis (CG, n=110). The groups were assessed by means of the Structured Clinical Interview DSM-IV (SCID-IV). AG participants were recruited among outpatients from the university hospital, whereas CG participants were recruited from a primary healthcare program. Data collection was done individually with self-assessment instruments. Parametric statistics were performed, and a significance level of P=0.05 was adopted. A positive correlation was observed between openness and the length of time that alcohol has been consumed, as were significant and negative correlations between conscientiousness and both the length of time alcohol has been consumed and the number of doses. For alcoholics, extraversion emerged as a protective factor against depression development (P=0.008) and tobacco abuse (P=0.007), whereas openness worked as a protective factor against anxiety (P=0.02). The findings point to specific deficits presented by alcoholics in relation to personality traits with or without psychiatric comorbidities and to the understanding that therapeutic approaches should favor procedures and/or preventive measures that allow more refined awareness about the disorder.
DOI: 10.6084/m9.figshare.7942157
title: Brazilian Breast Cancer Care Network: the perspective of health managers

description: ABSTRACT Objective: To analyze the organization of the Brazilian Breast Cancer Care Network, according to the perspective of managers of the Coordenadoria Regional de Saúde Sudeste (Southeast Regional Coordination of Health) of the city of São Paulo. Method: A descriptive study, with a qualitative approach, carried out with seven managers of this Coordination. The interview data were analyzed based on the components of the operational structure of the Brazilian Health Care Network: Communication Center; Secondary and Tertiary Care Points; Support Systems; Logistic Systems; and Network Governance System. Results: There is heterogeneity in the operationalization of the Care Network and the obstacles to its integration and comprehensiveness were: fragility of the bond with the users; high turnover of professionals in Primary Health Care; lack of standardization of the reference system and counter-referral, and low cooperation between municipal and state health services. Final considerations: The organization of the Brazilian Breast Cancer Care Network is fragmented, thus compromising the comprehensiveness of care.
DOI: 10.6084/m9.figshare.7942160.v1
title: Particles panels prepared from dendê mesocarp as an alternative to MDF used in civil construction

description: ABSTRACT The lack of forest resources integrated with the need of purchasing more environmentally friendly products requires the use of other types of biomass besides wood in the construction sector. Therefore, the dendê mesocarp - waste arising from the agro-industry and with great use potential in developing new materials - is an alternative in the preparation of lignocellulosic panels to replace MDF (Medium Density Fiberboard), that is conventionally used. Thus, this work demonstrated the feasibility of the production and the structural integrity of this type of panel in the manufacture of building blocks to be used in civil construction through a comparative study of their properties with the MDF panels. The methodology consists in performing characterization tests in panels through determining their physical (water absorption, swelling and density) and mechanical (flexion resistance and modulus of elasticity) properties, besides analysing the morphology of the panels produced by the Scanning Electron Microscopy (MEV) technique, performing a chemical (via infrared spectrum Fourier transform) and thermal analysis through derived thermogravimetric curves. The results obtained suggest that the production of these panels without a binder, obtained by the incorporation of dendê mesocarp, adds value to the production chain of dendê, in addition to emerge as an alternative to the challenges inherent to the traditional production of wood panels and, consequently, is considered as an option of a constructive element to be integrated with the construction.
DOI: 10.6084/m9.figshare.7942151.v1
title: Mathematical Intradisciplinarity with GeoGebra in School Mathematics

description: Abstract In this paper, we discuss the intradisciplinary work in school mathematics and bring evidences that the use of GeoGebra favors it. In order to do so, we question the process of disciplining science that contributed to the deepening of various areas, at the same time as it propelled a growing dissociation among them. Similarly, the hyper-specialization of mathematical knowledge has contributed to the fragmentation of school mathematics in the arithmetic, geometry, and algebra ramifications, which has made it difficult to learn by the students. Seeking the balance between fragmentation and totalization, we investigated the intradisciplinarity of school mathematics with GeoGebra. We used a qualitative research methodology and we analyzed an activity of proportional reasoning exploration developed with mathematics teachers from an elementary school. The analysis indicate that GeoGebra allows for the exploration of multiple representations that highlight particularities of the mathematical fronts through its diverse resources and windows that present the dynamically connected mathematical objects, which contributes in a way that the disadvantages of each representation are satisfied by the advantages of the others in teaching and learning mathematics. We concluded that the intradisciplinary mathematical approach with GeoGebra emphasizes the concomitant work among the different mathematical ramifications and offers the teachers the possibility of exploring it in their pedagogical practice.
DOI: 10.6084/m9.figshare.7942154.v1
title: Personality traits and psychiatric comorbidities in alcohol dependence

description: Non-adaptive personality traits may constitute risk factors for development of psychiatric disorders such as depression and anxiety. We aim to evaluate associations and the predictive value of personality traits among alcohol-dependent individuals, with or without psychiatric comorbidities. The convenience sample comprised two groups of males over 18 years of age: one with subjects who had an alcohol dependence diagnosis (AG, n=110), and a control group without abuse and/or alcohol dependence diagnosis (CG, n=110). The groups were assessed by means of the Structured Clinical Interview DSM-IV (SCID-IV). AG participants were recruited among outpatients from the university hospital, whereas CG participants were recruited from a primary healthcare program. Data collection was done individually with self-assessment instruments. Parametric statistics were performed, and a significance level of P=0.05 was adopted. A positive correlation was observed between openness and the length of time that alcohol has been consumed, as were significant and negative correlations between conscientiousness and both the length of time alcohol has been consumed and the number of doses. For alcoholics, extraversion emerged as a protective factor against depression development (P=0.008) and tobacco abuse (P=0.007), whereas openness worked as a protective factor against anxiety (P=0.02). The findings point to specific deficits presented by alcoholics in relation to personality traits with or without psychiatric comorbidities and to the understanding that therapeutic approaches should favor procedures and/or preventive measures that allow more refined awareness about the disorder.
DOI: 10.6084/m9.figshare.7942157.v1
title: Brazilian Breast Cancer Care Network: the perspective of health managers

description: ABSTRACT Objective: To analyze the organization of the Brazilian Breast Cancer Care Network, according to the perspective of managers of the Coordenadoria Regional de Saúde Sudeste (Southeast Regional Coordination of Health) of the city of São Paulo. Method: A descriptive study, with a qualitative approach, carried out with seven managers of this Coordination. The interview data were analyzed based on the components of the operational structure of the Brazilian Health Care Network: Communication Center; Secondary and Tertiary Care Points; Support Systems; Logistic Systems; and Network Governance System. Results: There is heterogeneity in the operationalization of the Care Network and the obstacles to its integration and comprehensiveness were: fragility of the bond with the users; high turnover of professionals in Primary Health Care; lack of standardization of the reference system and counter-referral, and low cooperation between municipal and state health services. Final considerations: The organization of the Brazilian Breast Cancer Care Network is fragmented, thus compromising the comprehensiveness of care.
DOI: 10.6084/m9.figshare.7942163.v1
title: Assessment of the diagnostic value of diffusion tensor imaging in patients with spinal cord compression: a meta-analysis

description: We investigated the diagnostic value of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of magnetic resonance diffusion tensor imaging (DTI) in patients with spinal cord compression (SCC) using a meta-analysis framework. Multiple scientific literature databases were exhaustively searched to identify articles relevant to this study. Mean values and standardized mean differences (SMDs) were calculated for the ADC and FA in normal and diseased tissues. The STATA version 12.0 software was used for statistical analysis. Of the 41 articles initially retrieved through database searches, 11 case-control studies were eligible for the meta-analysis and contained a combined total of 645 human subjects (394 patients with SCC and 251 healthy controls). All 11 studies reported data on FA, and 9 contained data related to the ADC. The combined SMDs of the ADC and FA showed that the ADC was significantly higher and the FA was lower in patients with SCC than in healthy controls. Subgroup analysis based on the b value showed higher ADCs in patients with SCC than in healthy controls at b values of both ≤500 and &gt;500 s/mm2. In summary, the main findings of this meta-analysis revealed an increased ADC and decreased FA in patients with SCC, indicating that DTI is an important diagnostic imaging tool to assess patients suspected to have SCC.