cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13032989.v1
title: dataAGU.zip

description: The data was acquired West Bengal, India. The three magnetic components are recorded by the induction coils MFS-06 and the two horizontal electric components by non-polarizing electrodes Pb–PbCl<sub>2</sub>. The distance between the electrodes for electric field measurement is 80 m. We represent northward and eastward by the x- and y-components while the z represents a vertical component. The data sets are recorded using the ADU-06 (M/s Metronix GmbH). Time-series of the data sets (electric and magnetic components) are attached.<br>
DOI: 10.5281/zenodo.4061382
title: Comparative genomics of Meloidogyne haplanaria

description: Data related to the MSC thesis 'Comparative genomics of Meloidogyne haplanaria'.
DOI: 10.5281/zenodo.4040673
title: Comparative genomics of Meloidogyne haplanaria

description: Data related to the MSC thesis 'Comparative genomics of Meloidogyne haplanaria'.
DOI: 10.21253/dmu.13011182
title: Data from market interaction experiments

description: Data-set on market interaction classroom experiments. Data is described and analysed in the paper: 'Classroom market experiments: Data and reflections' by Anna Cartwright and Edward Cartwright.
DOI: 10.21253/dmu.13011182.v1
title: Data from market interaction experiments

description: Data-set on market interaction classroom experiments. Data is described and analysed in the paper: 'Classroom market experiments: Data and reflections' by Anna Cartwright and Edward Cartwright.
DOI: 10.5281/zenodo.4061678
title: FDG PETCT baseline scans in 10 cases of DLBCL

description: This dataset contains 10 anonymous cases of FDG PET/CT baseline studies in DLBCL patients
DOI: 10.5281/zenodo.4061677
title: FDG PETCT baseline scans in 10 cases of DLBCL

description: This dataset contains 10 anonymous cases of FDG PET/CT baseline studies in DLBCL patients
DOI: 10.5281/zenodo.4061684
title: Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m)

description: Recent studies on Andean children indicate a prevalence of dyslipidemia and hypertension compared to dwellers at lower altitudes, suggesting that despite similar food intake and daily activities, they undergo different metabolic adaptations. In the present study, the sphingolipid pattern was investigated in serum of 7 underweight (UW), 30 normal weight (NW), 13 overweight (OW), and 9 obese (O) Andean children by liquid chromatography-mass spectrometry (LC-MS). Results indicate that levels of Ceramides (Cers) and sphingomyelins (SMs) correlate positively with biochemical parameters (except for Cers and Vitamin D, which correlate negatively), whereas sphingosine-1-phosphate (S1P) correlates negatively. Correlation results and LC-MS data identify the axis high density lipoprotein-cholesterol (HDL-C), Cers, and S1P as related to hypoxia adaptation. Specifically UW children are characterized by increased levels of S1P compared to O and lower levels of Cers compared to NW children. Furthermore, O children show lower levels of S1P and similar levels of Cers and SMs as NW. In conclusion, our results indicate that S1P is the primary target of hypoxia adaptation in Andean children, and its levels are associated with hypoxia tolerance. Furthermore, S1P can act as marker of increased risk of metabolic syndrome and cardiac dysfunction in young Andeans living at altitude
DOI: 10.5281/zenodo.4061683
title: Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m)

description: Recent studies on Andean children indicate a prevalence of dyslipidemia and hypertension compared to dwellers at lower altitudes, suggesting that despite similar food intake and daily activities, they undergo different metabolic adaptations. In the present study, the sphingolipid pattern was investigated in serum of 7 underweight (UW), 30 normal weight (NW), 13 overweight (OW), and 9 obese (O) Andean children by liquid chromatography-mass spectrometry (LC-MS). Results indicate that levels of Ceramides (Cers) and sphingomyelins (SMs) correlate positively with biochemical parameters (except for Cers and Vitamin D, which correlate negatively), whereas sphingosine-1-phosphate (S1P) correlates negatively. Correlation results and LC-MS data identify the axis high density lipoprotein-cholesterol (HDL-C), Cers, and S1P as related to hypoxia adaptation. Specifically UW children are characterized by increased levels of S1P compared to O and lower levels of Cers compared to NW children. Furthermore, O children show lower levels of S1P and similar levels of Cers and SMs as NW. In conclusion, our results indicate that S1P is the primary target of hypoxia adaptation in Andean children, and its levels are associated with hypoxia tolerance. Furthermore, S1P can act as marker of increased risk of metabolic syndrome and cardiac dysfunction in young Andeans living at altitude
DOI: 10.5285/7df163a1-30c6-40b6-844d-20fa0acffd18
title: Five Deeps Expedition to map the western Puerto Rico Trench (Atlantic Ocean)

description: The Brownson Deep area of the Puerto Rico Trench was surveyed with a Kongsberg EM 124 gondola-mounted to the hull of the 225-foot DSSV Pressure Drop. The survey was conducted over the course of two days – December 18-19, 2018. The data meet the requirements for IHO Special Order standards.
DOI: 10.15479/at:ista:108
title: Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring
title: Subtitle

description: Mean repression values and standard error of the mean are given for all operator mutant libraries.
DOI: 10.5517/ccdc.csd.cc25850n
title: CCDC 2003840: Experimental Crystal Structure Determination

description: Related Article: Toyoharu Kobayashi, Yui Tomita, Yuichiro Kawamoto, Hisanaka Ito|2020|Org.Biomol.Chem.|18|7316|doi:10.1039/D0OB01430C
DOI: 10.5517/ccdc.csd.cc25jwn8
title: CCDC 2012230: Experimental Crystal Structure Determination

description: Related Article: Dibya Jyoti Mondal, Subhadip Roy, Jyoti Yadav, Matthias Zeller, Sanjit Konar|2020|Inorg.Chem.|59|13024|doi:10.1021/acs.inorgchem.0c02240
DOI: 10.5285/143e304e-b9d5-43bf-b323-f2ab517bc18b
title: Five Deeps Expedition to map the South Sandwich Trench (spanning the Atlantic and Southern oceans)

description: The South Sandwich Trench was surveyed with a Kongsberg EM 124 gondola-mounted to the hull of the 225-foot DSSV Pressure Drop. The survey was conducted over the course of seven days – February 2-9, 2019. The data meet the requirements for IHO Special Order standards.
DOI: 10.6084/m9.figshare.12362162
title: Laboratory findings of COVID-19: a systematic review and meta-analysis

description: The Coronavirus Disease (COVID-19) pandemic first broke out in December 2019 in Wuhan, China, and has now spread worldwide. Laboratory findings have been only partially described in some observational studies. To date, more comprehensive systematic reviews of laboratory findings on COVID-19 are missing. We performed a systematic review with a meta-analysis to assess laboratory findings in patients with COVID-19. Observational studies from three databases were selected. We calculated pooled proportions and 95% confidence interval (95% CI) using the random-effects model meta-analysis. A total of 1106 articles were identified from PubMed, Web of Science, CNKI (China), and other sources. After screening, 28 and 7 studies were selected for a systematic review and a meta-analysis, respectively. Of the 4,663 patients included, the most prevalent laboratory finding was increased C-reactive protein (CRP; 73.6%, 95% CI 65.0–81.3%), followed by decreased albumin (62.9%, 95% CI 28.3–91.2%), increased erythrocyte sedimentation rate (61.2%, 95% CI 41.3–81.0%), decreased eosinophils (58.4%, 95% CI 46.5–69.8%), increased interleukin-6 (53.1%, 95% CI 36.0–70.0%), lymphopenia (47.9%, 95% CI 41.6–54.9%), and increased lactate dehydrogenase (LDH; 46.2%, 95% CI 37.9–54.7%). A meta-analysis of seven studies with 1905 patients showed that increased CRP (OR 3.0, 95% CI: 2.1–4.4), lymphopenia (OR 4.5, 95% CI: 3.3–6.0), and increased LDH (OR 6.7, 95% CI: 2.4–18.9) were significantly associated with severity. These results demonstrated that more attention is warranted when interpreting laboratory findings in patients with COVID-19. Patients with elevated CRP levels, lymphopenia, or elevated LDH require proper management and, if necessary, transfer to the intensive care unit.
DOI: 10.6084/m9.figshare.12362162.v1
title: Laboratory findings of COVID-19: a systematic review and meta-analysis

description: The Coronavirus Disease (COVID-19) pandemic first broke out in December 2019 in Wuhan, China, and has now spread worldwide. Laboratory findings have been only partially described in some observational studies. To date, more comprehensive systematic reviews of laboratory findings on COVID-19 are missing. We performed a systematic review with a meta-analysis to assess laboratory findings in patients with COVID-19. Observational studies from three databases were selected. We calculated pooled proportions and 95% confidence interval (95% CI) using the random-effects model meta-analysis. A total of 1106 articles were identified from PubMed, Web of Science, CNKI (China), and other sources. After screening, 28 and 7 studies were selected for a systematic review and a meta-analysis, respectively. Of the 4,663 patients included, the most prevalent laboratory finding was increased C-reactive protein (CRP; 73.6%, 95% CI 65.0–81.3%), followed by decreased albumin (62.9%, 95% CI 28.3–91.2%), increased erythrocyte sedimentation rate (61.2%, 95% CI 41.3–81.0%), decreased eosinophils (58.4%, 95% CI 46.5–69.8%), increased interleukin-6 (53.1%, 95% CI 36.0–70.0%), lymphopenia (47.9%, 95% CI 41.6–54.9%), and increased lactate dehydrogenase (LDH; 46.2%, 95% CI 37.9–54.7%). A meta-analysis of seven studies with 1905 patients showed that increased CRP (OR 3.0, 95% CI: 2.1–4.4), lymphopenia (OR 4.5, 95% CI: 3.3–6.0), and increased LDH (OR 6.7, 95% CI: 2.4–18.9) were significantly associated with severity. These results demonstrated that more attention is warranted when interpreting laboratory findings in patients with COVID-19. Patients with elevated CRP levels, lymphopenia, or elevated LDH require proper management and, if necessary, transfer to the intensive care unit.
DOI: 10.6084/m9.figshare.12850064
title: Molecular screening of familial hypercholesterolemia in Icelanders

description: Familial hypercholesterolemia (FH) is a monogenic disease characterized by a lifelong exposure to high LDL-C levels that can lead to early onset coronary heart disease (CHD). The main causes of FH identified to date include loss-of-function mutations in <i>LDLR</i> or <i>APOB</i>, or gain-of-function mutations in <i>PCSK9</i>. Early diagnosis and genetic testing of FH suspects is critical for improved prognosis of affected individuals as lipid lowering treatments are effective in preventing CHD related morbidity and mortality. In the present study, we carried out a comprehensive screening, using a next-generation sequencing (NGS) panel, for FH culprit mutations in two Icelandic studies representative of either FH families or the general population. We confirmed all previously known mutations in the FH families, and identified two subjects that had been misdiagnosed clinically at young age. We identified six new mutations in the Icelandic FH families and detected three pathogenic mutations in the general population-based study. The application of the NGS panel revealed substantial diagnostic yields in identifying pathogenic mutations, or 68.2% of those with definite clinical diagnosis of FH in the family material and 5.6-fold enrichment in the population-based genetic testing.
DOI: 10.6084/m9.figshare.12850064.v1
title: Molecular screening of familial hypercholesterolemia in Icelanders

description: Familial hypercholesterolemia (FH) is a monogenic disease characterized by a lifelong exposure to high LDL-C levels that can lead to early onset coronary heart disease (CHD). The main causes of FH identified to date include loss-of-function mutations in <i>LDLR</i> or <i>APOB</i>, or gain-of-function mutations in <i>PCSK9</i>. Early diagnosis and genetic testing of FH suspects is critical for improved prognosis of affected individuals as lipid lowering treatments are effective in preventing CHD related morbidity and mortality. In the present study, we carried out a comprehensive screening, using a next-generation sequencing (NGS) panel, for FH culprit mutations in two Icelandic studies representative of either FH families or the general population. We confirmed all previously known mutations in the FH families, and identified two subjects that had been misdiagnosed clinically at young age. We identified six new mutations in the Icelandic FH families and detected three pathogenic mutations in the general population-based study. The application of the NGS panel revealed substantial diagnostic yields in identifying pathogenic mutations, or 68.2% of those with definite clinical diagnosis of FH in the family material and 5.6-fold enrichment in the population-based genetic testing.
DOI: 10.5285/1c642df0-905a-4936-97dd-81b50d7c3994
title: Five Deeps Expedition to map the Tonga Trench (Pacific Ocean)

description: The Tonga Trench was surveyed with a Kongsberg EM 124 gondola-mounted to the hull of the 225-foot DSSV Pressure Drop. The survey was conducted over the course of two weeks – May 29 – June 6, 2019. The data meet the requirements for IHO Special Order standards.
DOI: 10.5281/zenodo.4061696
title: Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

description: <strong>Background:</strong> Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA. HapA/HapA homozygous (HomoA) subjects show a reduced susceptibility to HIV-1 infection, probably secondary to the modulation of the antigen processing/presenting machinery. ERAP1 was recently shown to be secreted from the plasma membrane in response to activation; we investigated whether ERAP2 can be released as well and if the secreted form of this enzyme retains its antiviral function. <strong>Methods:</strong> Human monocyte derived macrophages (MDMs) were differentiated from peripheral blood mononuclear cells (PBMCs) isolated from 6 HomoA healthy controls and stimulated with IFNγ and LPS. ERAP2-FL secretion was evaluated by mass spectrometry. PBMCs (14 HomoA and 16 HomoB) and CD8-depleted PBMCs (CD8<sup>−</sup>PBMCs) (4 HomoA and 4 HomoB) were <em>in vitro</em> HIV-infected in the absence/presence of recombinant human ERAP2-FL (rhERAP2) protein; p24 viral antigen quantification was used to assess viral replication. IFNγ and CD69 mRNA expression, as well as the percentage of perforin-producing CD8+ T Lymphocytes, were analyzed 3 and 7-days post <em>in vitro</em> HIV-1-infection, respectively. The effect of rhERAP2 addition in cell cultures on T cell apoptosis, proliferation, activation, and maturation was evaluated as well on 24 h-stimulated PBMCs. <strong>Results:</strong> ERAP2 can be secreted from human MDMs in response to IFNγ/LPS stimulation. Notably, the addition of rhERAP2 to PBMC and CD8<sup>−</sup>PBMC cultures resulted in the reduction of viral replication, though these differences were statistically significant only in PBMCs (<em>p</em> &lt; 0.05 in both HomoA and HomoB). This protective effect was associated with an increase in IFNγ and CD69 mRNA expression and in the percentage of perforin-expressing CD107<sup>+</sup>CD8<sup>+</sup> cells. RhERAP2 addition also resulted in an increase in CD8<sup>+</sup> activated lymphocyte (CD25<sup>+</sup>HLA<sup>−</sup>DRII<sup>+</sup>) and Effector Memory/Terminally differentiated CD8<sup>+</sup> T cells ratio. <strong>Conclusions:</strong> This is the first report providing evidence for the release of ERAP2 in the secretome of immunocompetent cells. Data herein also indicate that exogenous ERAP2-FL exerts its protective function against HIV-1 infection, even in HomoB subjects who do not genetically produce it. Presumably, this defensive extracellular feature is only partially dependent on immune system modulation.
DOI: 10.5281/zenodo.4061695
title: Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

description: <strong>Background:</strong> Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA. HapA/HapA homozygous (HomoA) subjects show a reduced susceptibility to HIV-1 infection, probably secondary to the modulation of the antigen processing/presenting machinery. ERAP1 was recently shown to be secreted from the plasma membrane in response to activation; we investigated whether ERAP2 can be released as well and if the secreted form of this enzyme retains its antiviral function. <strong>Methods:</strong> Human monocyte derived macrophages (MDMs) were differentiated from peripheral blood mononuclear cells (PBMCs) isolated from 6 HomoA healthy controls and stimulated with IFNγ and LPS. ERAP2-FL secretion was evaluated by mass spectrometry. PBMCs (14 HomoA and 16 HomoB) and CD8-depleted PBMCs (CD8<sup>−</sup>PBMCs) (4 HomoA and 4 HomoB) were <em>in vitro</em> HIV-infected in the absence/presence of recombinant human ERAP2-FL (rhERAP2) protein; p24 viral antigen quantification was used to assess viral replication. IFNγ and CD69 mRNA expression, as well as the percentage of perforin-producing CD8+ T Lymphocytes, were analyzed 3 and 7-days post <em>in vitro</em> HIV-1-infection, respectively. The effect of rhERAP2 addition in cell cultures on T cell apoptosis, proliferation, activation, and maturation was evaluated as well on 24 h-stimulated PBMCs. <strong>Results:</strong> ERAP2 can be secreted from human MDMs in response to IFNγ/LPS stimulation. Notably, the addition of rhERAP2 to PBMC and CD8<sup>−</sup>PBMC cultures resulted in the reduction of viral replication, though these differences were statistically significant only in PBMCs (<em>p</em> &lt; 0.05 in both HomoA and HomoB). This protective effect was associated with an increase in IFNγ and CD69 mRNA expression and in the percentage of perforin-expressing CD107<sup>+</sup>CD8<sup>+</sup> cells. RhERAP2 addition also resulted in an increase in CD8<sup>+</sup> activated lymphocyte (CD25<sup>+</sup>HLA<sup>−</sup>DRII<sup>+</sup>) and Effector Memory/Terminally differentiated CD8<sup>+</sup> T cells ratio. <strong>Conclusions:</strong> This is the first report providing evidence for the release of ERAP2 in the secretome of immunocompetent cells. Data herein also indicate that exogenous ERAP2-FL exerts its protective function against HIV-1 infection, even in HomoB subjects who do not genetically produce it. Presumably, this defensive extracellular feature is only partially dependent on immune system modulation.
DOI: 10.21227/8e1n-fs75
title: Gaming Network Traffic Dataset

description: Gaming consoles are very common connected devices which have evolved in functionality and applications (games and beyond) they support. This diversity of traffic generated from these consoles has diverse quality of service (QoS) requirements. However, in order to offer diverse QoS, ISPs and operators must be able to classify this traffic. To enable research in traffic classification (Machine Learning based or other), we have generated and collected this dataset. This is a labelled dataset collected from a gaming console, PlayStation 4. The data was collected for a period of 2 weeks from July 26, 2020 till August 12, 2020. The data was collected 3 times a day (morning, afternoon, evening). There is a total of 41 rounds of data collection.
DOI: 10.25934/00003637.0
title: Available IPD datapackage for study 'A 52 Weeks, Double Blind, Randomized, Placebo-controlled Trial Evaluating the Effect of Oral BIBF 1120, 150 mg Twice Daily, on Annual Forced Vital Capacity Decline, in Patients With Idiopathic Pulmonary Fibrosis (IPF)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.6084/m9.figshare.13033262
title: all_generated_compounds.csv

description: Dataset of all possible (AA')BO3 and A(BB')O3 compositions<br>
DOI: 10.6084/m9.figshare.12130932
title: SARSraw_data.pdf

description: Docking scores to SARS-CoV-2 S-protein, human ACE2 receptor and their interface from ChemPLP docking algorithm as implemented in the Gold program, MOE descriptors used in QSAR, List of substructures generated by RECAP algorithm used as counts in QSAR modeling, results of ADME calculations
DOI: 10.6084/m9.figshare.12130932.v3
title: SARSraw_data.pdf

description: Docking scores to SARS-CoV-2 S-protein, human ACE2 receptor and their interface from ChemPLP docking algorithm as implemented in the Gold program, MOE descriptors used in QSAR, List of substructures generated by RECAP algorithm used as counts in QSAR modeling, results of ADME calculations
DOI: 10.6084/m9.figshare.12130932.v2
title: SARSraw_data.pdf

description: Docking scores to SARS-CoV-2 S-protein, human ACE2 receptor and their interface from ChemPLP docking algorithm as implemented in the Gold program, MOE descriptors used in QSAR, results of ADME calculations
DOI: 10.34740/kaggle/dsv/849937
title: Generated_NPs
DOI: 10.6084/m9.figshare.13032722
title: Ni-2-CPT-OMe_B3LYP-631Gd.xyz

description: Optimized Structure from DFT calculations (B3LYP/6-31G(d)).<br>
DOI: 10.6084/m9.figshare.13032722.v1
title: Ni-2-CPT-OMe_B3LYP-631Gd.xyz

description: Optimized Structure from DFT calculations (B3LYP/6-31G(d)).<br>
DOI: 10.5281/zenodo.4061740
title: Fracture dolomite as an archive of continental palaeo-environmental conditions

description: Supplementary Information File (raw data; Table 1-8) to the article "Fracture dolomite as an archive of continental palaeo-environmental conditions", published in Communications Earth & Environment
description: Funding of the NAWI Graz Central Laboratory for Water, Minerals and Rocks is highly appreciated through the EFRE-Land Steiermark initiative. T.K. acknowledges that the IRMS for clumped isotope analyses at Heidelberg University was funded through grant DFG-INST 35/1270-1. X.W. acknowledges funding support from the National Research Foundation of Singapore (grant no. NRF2017NRF-NSFC001-047) and the Earth Observatory of Singapore.
DOI: 10.5281/zenodo.4061739
title: Fracture dolomite as an archive of continental palaeo-environmental conditions

description: Supplementary Information File (raw data; Table 1-8) to the article "Fracture dolomite as an archive of continental palaeo-environmental conditions", published in Communications Earth & Environment
description: Funding of the NAWI Graz Central Laboratory for Water, Minerals and Rocks is highly appreciated through the EFRE-Land Steiermark initiative. T.K. acknowledges that the IRMS for clumped isotope analyses at Heidelberg University was funded through grant DFG-INST 35/1270-1. X.W. acknowledges funding support from the National Research Foundation of Singapore (grant no. NRF2017NRF-NSFC001-047) and the Earth Observatory of Singapore.
DOI: 10.21227/phqn-zm63
title: Latency measurments API gateway

description: This dataset contains requests execution times for comparison of direct requests and requests via API gateway to test API.