cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14790267
title: Supplementary Material for: Transplacental Transfer and Fetal Pharmacodynamics of Sildenafil in the Pregnant Sheep Model

description: <b><i>Background:</i></b> Sildenafil is a phosphodiesterase-5 inhibitor considered for antenatal use for a variety of indications. We sought to assess sildenafil pharmacokinetics in the pregnant ewe and fetus and evaluate its physiological fetal effects. <b><i>Methods:</i></b> Twelve fetal lambs (127–133 days GA, term 145) were chronically catheterized in utero. Ewes received different doses of sildenafil, either via subcutaneous injection (1.6, 2.0 mg/kg/day) or intravenous (IV) infusion (3, 5, 7, 10, and 12 mg/kg/day). Maternal and fetal sildenafil concentrations and metabolic status (blood gas analysis) were measured at given intervals. The fetal heart rate, pulmonary blood flow, systemic and aortic pressure, and maternal uterine artery pressure were continuously monitored. <b><i>Results:</i></b> The transplacental sildenafil transfer was 2.9% (range: 1.4–7.8%), preventing attainment of fetal target concentrations without toxic maternal levels. IV sildenafil infusion induced an immediate, temporary, dose-dependent reduction of pulmonary vascular resistance (38–78%) and increased both pulmonary blood flow (32–132%) and heart rate (13–49%), with limited nonlinear dose-dependent effects on systemic and pulmonary pressures. Fetal and maternal blood gases and maternal uterine artery pressures were unaffected by sildenafil infusion. <b><i>Conclusion:</i></b> In sheep, transplacental transfer of sildenafil is extremely low. Though, minimal fetal sildenafil concentrations induce an acute transient pulmonary vasodilation, well-tolerated by the fetus and ewe.
DOI: 10.6084/m9.figshare.14790267.v1
title: Supplementary Material for: Transplacental Transfer and Fetal Pharmacodynamics of Sildenafil in the Pregnant Sheep Model

description: <b><i>Background:</i></b> Sildenafil is a phosphodiesterase-5 inhibitor considered for antenatal use for a variety of indications. We sought to assess sildenafil pharmacokinetics in the pregnant ewe and fetus and evaluate its physiological fetal effects. <b><i>Methods:</i></b> Twelve fetal lambs (127–133 days GA, term 145) were chronically catheterized in utero. Ewes received different doses of sildenafil, either via subcutaneous injection (1.6, 2.0 mg/kg/day) or intravenous (IV) infusion (3, 5, 7, 10, and 12 mg/kg/day). Maternal and fetal sildenafil concentrations and metabolic status (blood gas analysis) were measured at given intervals. The fetal heart rate, pulmonary blood flow, systemic and aortic pressure, and maternal uterine artery pressure were continuously monitored. <b><i>Results:</i></b> The transplacental sildenafil transfer was 2.9% (range: 1.4–7.8%), preventing attainment of fetal target concentrations without toxic maternal levels. IV sildenafil infusion induced an immediate, temporary, dose-dependent reduction of pulmonary vascular resistance (38–78%) and increased both pulmonary blood flow (32–132%) and heart rate (13–49%), with limited nonlinear dose-dependent effects on systemic and pulmonary pressures. Fetal and maternal blood gases and maternal uterine artery pressures were unaffected by sildenafil infusion. <b><i>Conclusion:</i></b> In sheep, transplacental transfer of sildenafil is extremely low. Though, minimal fetal sildenafil concentrations induce an acute transient pulmonary vasodilation, well-tolerated by the fetus and ewe.
DOI: 10.6084/m9.figshare.14790135
title: Supplementary Material for: Relationship between the <b><i>FTO</i></b> Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria

description: <b><i>Introduction:</i></b> Single nucleotide polymorphisms (SNP) in the fat mass and obesity-associated (<i>FTO</i>) gene have been associated with type 2 diabetes (T2D) and its complications. The aim of the present research was to investigate which and how (directly or indirectly) clinical and metabolic variables mediate the association between fat mass and the <i>FTO</i> gene and early chronic kidney disease (CKD) in individuals with T2D. <b><i>Methods:</i></b> This cross-sectional study was conducted in a sample of 236 participants with T2D (53.4% women, mean age 60 ± 10 years). DNA samples were genotyped for the rs7204609 polymorphism (C/T) in the <i>FTO</i> gene. Clinical, anthropometric, and metabolic data were collected. Path analysis was used to evaluate the associations. <b><i>Results:</i></b> Of the sample, 78 individuals with T2D had CKD (33%). Presence of the risk allele (<i>C</i>) was higher among participants with CKD (21.8 vs. 10.8%; <i>p</i> = 0.023). This polymorphism was positively associated with higher waist circumference, which in turn was associated with higher glycated hemoglobin and higher blood pressure. A higher blood-pressure level was associated with higher urinary albumin excretion (UAE) and as expected, higher UAE was associated with CKD. Path analysis showed an indirect relationship between the <i>FTO</i> gene and early CKD, mediated by waist circumference, blood-pressure levels, and UAE. <b><i>Conclusions:</i></b> These findings suggest that the <i>C</i> allele may contribute to genetic susceptibility to CKD in individuals with T2D through the presence of central obesity, hypertension, and high albuminuria.
DOI: 10.15468/se3ynn
title: Bacterioplankon from lakes on Byers Peninsula (2008)

description: Amplicon sequencing dataset (Illumina MiSeq) targeting Bacteria (16S ssu rRNA) in samples (n=9) taken in 2008 from Byers Peninsula (Antarctica).
DOI: 10.5281/zenodo.4964287
title: ECA&D data for creation of weather prediction dataset

description: <strong>Original weather data taken to create the "Weather prediction dataset".</strong> Data was downloaded from http://www.ecad.eu in April 2021.<br> The source of the data is hence the following: EUROPEAN CLIMATE ASSESSMENT & DATASET (ECA&D), file created on 22-04-2021<br> THESE DATA CAN BE USED FREELY PROVIDED THAT THE FOLLOWING SOURCE IS ACKNOWLEDGED: Klein Tank, A.M.G. and Coauthors, 2002. Daily dataset of 20th-century surface<br> air temperature and precipitation series for the European Climate Assessment.<br> Int. J. of Climatol., 22, 1441-1453.<br> Data and metadata available at http://www.ecad.eu <br> -----------<br> Physical units of the variables:<br> ---------- DATA UNITS:<br> CC : cloud cover in oktas<br> DD : wind direction in degrees<br> FG : wind speed in 0.1 m/s<br> FX : wind gust in 0.1 m/s<br> HU : humidity in 1 %<br> PP : sea level pressure in 0.1 hPa<br> QQ : global radiation in W/m2<br> RR : precipitation amount in 0.1 mm<br> SS : sunshine in 0.1 Hours<br> TG : mean temperature in 0.1 &#176;C<br> TN : minimum temperature in 0.1 &#176;C<br> TX : maximum temperature in 0.1 &#176;C
DOI: 10.5281/zenodo.4964286
title: ECA&D data for creation of weather prediction dataset

description: <strong>Original weather data taken to create the "Weather prediction dataset".</strong> Data was downloaded from http://www.ecad.eu in April 2021.<br> The source of the data is hence the following: EUROPEAN CLIMATE ASSESSMENT & DATASET (ECA&D), file created on 22-04-2021<br> THESE DATA CAN BE USED FREELY PROVIDED THAT THE FOLLOWING SOURCE IS ACKNOWLEDGED: Klein Tank, A.M.G. and Coauthors, 2002. Daily dataset of 20th-century surface<br> air temperature and precipitation series for the European Climate Assessment.<br> Int. J. of Climatol., 22, 1441-1453.<br> Data and metadata available at http://www.ecad.eu <br> -----------<br> Physical units of the variables:<br> ---------- DATA UNITS:<br> CC : cloud cover in oktas<br> DD : wind direction in degrees<br> FG : wind speed in 0.1 m/s<br> FX : wind gust in 0.1 m/s<br> HU : humidity in 1 %<br> PP : sea level pressure in 0.1 hPa<br> QQ : global radiation in W/m2<br> RR : precipitation amount in 0.1 mm<br> SS : sunshine in 0.1 Hours<br> TG : mean temperature in 0.1 &#176;C<br> TN : minimum temperature in 0.1 &#176;C<br> TX : maximum temperature in 0.1 &#176;C
DOI: 10.5522/04/13862309
title: Data for manuscript 'GMP compliant isolation of mucosal epithelial cells and fibroblasts from biopsy samples for clinical tissue engineering.'

description: Data points for figure 1, 2, 3, 4 and 6. GraphPad Prism 8 files
DOI: 10.5281/zenodo.4964386
title: Citizen Science in Action: Data on librarians and users perceptions of participating in a citizen science project

description: Data collected during the one year project (2018-2019) Citizen Science in Action promoted by the Barcelona Network of Public Libraries (Spain). The project was structured around two interdependent and hands-on activities offered to librarians as part of their lifelong training. The activities were: the Citizen Science Lab; and Science and Citizen Action. The Citizen Science Lab consisted of an introductory course of 5 two-hour citizen science capacitation sessions addressed at 30 librarians from 24 different libraries. The activity Science and Citizen Action involved 7 library professionals from three different libraries and their community of users and local associations in the co-design and implementation of a public behavioral experiment. The data covers the relatioship between librarians and library users' attitudes towards citizen science, their motivations to participate in a citizen science project, their perceived ability to implement a citizen science project (as for librarians) or to contribute to science (as for library users), and the participants intention to keep engaged with citizen science. For the Citizen Science Lab data on librarians engagement was collected through paper-based questionnaires at the beginning and at the end of the activity. For the Science and Citizen Action data on librarians engagement was collected at the beginning, middle and end of the activity. The Project was approved by the Ethics Committee of Universitat de Barcelona, and all methods were performed in accordance with the relevant guidelines and regulations.
DOI: 10.5281/zenodo.4964385
title: Citizen Science in Action: Data on librarians and users perceptions of participating in a citizen science project

description: Data collected during the one year project (2018-2019) Citizen Science in Action promoted by the Barcelona Network of Public Libraries (Spain). The project was structured around two interdependent and hands-on activities offered to librarians as part of their lifelong training. The activities were: the Citizen Science Lab; and Science and Citizen Action. The Citizen Science Lab consisted of an introductory course of 5 two-hour citizen science capacitation sessions addressed at 30 librarians from 24 different libraries. The activity Science and Citizen Action involved 7 library professionals from three different libraries and their community of users and local associations in the co-design and implementation of a public behavioral experiment. The data covers the relatioship between librarians and library users' attitudes towards citizen science, their motivations to participate in a citizen science project, their perceived ability to implement a citizen science project (as for librarians) or to contribute to science (as for library users), and the participants intention to keep engaged with citizen science. For the Citizen Science Lab data on librarians engagement was collected through paper-based questionnaires at the beginning and at the end of the activity. For the Science and Citizen Action data on librarians engagement was collected at the beginning, middle and end of the activity. The Project was approved by the Ethics Committee of Universitat de Barcelona, and all methods were performed in accordance with the relevant guidelines and regulations.
DOI: 10.24341/tethys.38
title: Geodaten - Blatt 75 Puchberg am Schneeberg (1:50.000)
title: Geodata - sheet 75 Puchberg am Schneeberg (1:50.000)

description: Die Geodaten wurden aus dem Kartenwerk GK50 „Geologische Karte der Republik Österreich 1:50.000“ abgeleitet. Die Datengrundlage basiert auf einer umfassenden Datenerhebung im Rahmen der gesetzlich verankerten geologischen Landesaufnahme von Österreich, welche eine umfangreiche Literaturrecherche, die Geländekartierung, sowie die Probenahme mit wissenschaftlichen Analysen und Messungen beinhaltet. Die im BMN-Blattschnitt veröffentlichten Geodaten entsprechen dem aktuellen Wissensstand zum Zeitpunkt des Kartendruckes und können geringfügig von den Originalen abweichen.
description: Die vorliegende Datenpublikation ist ein Bestandteil der Kartenserie „Geologische Karte der Republik Österreich 1:50.000“ (GK50), die im Zeitraum zwischen 1977 und 2017 veröffentlicht wurden und aus insgesamt 89 Geodatensätzen besteht. Eine ausführliche Datenbeschreibung wird mit den Kartendaten bereitgestellt und kann direkt zu jeder Publikation heruntergeladen werden.
description: This data publication is part of the map series "Geological Map of the Republic of Austria 1:50.000" (GK50), published between 1977 and 2017 consisting of 89 spatial data sets. A detailed data description is provided with the map data and can be downloaded together with the data publication.
DOI: 10.5517/ccdc.csd.cc1lfgwc
title: CCDC 1472713: Experimental Crystal Structure Determination

description: Related Article: Maciej Dębowski, Zbigniew Florjańczyk, Andrzej Ostrowski, Piotr A. Guńka, Janusz Zachara, Anna Krztoń-Maziopa, Jakub Chazarkiewicz, Anna Iuliano, Andrzej Plichta|2021|RSC Advances|11|7873|doi:10.1039/D0RA09493E
description: Related Article: Maciej Dębowski, Zbigniew Florjańczyk, Andrzej Ostrowski, Piotr A. Guńka, Janusz Zachara, Anna Krztoń-Maziopa, Jakub Chazarkiewicz, Anna Iuliano, Andrzej Plichta|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277clg
title: CCDC 2062665: Experimental Crystal Structure Determination

description: Related Article: Lucas S. Rodríguez Pirani, Antonela Cánneva, Mariana Geronés, Rosana M. Romano, Reinaldo Cavasso-Filho, Mauricio F. Erben, Roland Boese, Carlos O. Della Védova|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277q9j
title: CCDC 2062997: Experimental Crystal Structure Determination

description: Related Article: M.A. Velazquez Carmona, S. Bernes, P. De la Cruz Burelo, R.I. Sanchez Perez, L. Ysquierdo Rodriguez|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277w2g
title: CCDC 2063145: Experimental Crystal Structure Determination

description: Related Article: Nils Nöthling, Richard Goddard, Christian W. Lehmann|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277w3h
title: CCDC 2063146: Experimental Crystal Structure Determination

description: Related Article: Nils Nöthling, Richard Goddard, Christian W. Lehmann|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277w4j
title: CCDC 2063147: Experimental Crystal Structure Determination

description: Related Article: Nils Nöthling, Richard Goddard, Christian W. Lehmann|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277wm0
title: CCDC 2063162: Experimental Crystal Structure Determination

description: Related Article: Heather DiLallo, Dominic C. Babbini, Allen G. Oliver, Toni L. O. Barstis|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277wn1
title: CCDC 2063163: Experimental Crystal Structure Determination

description: Related Article: Heather DiLallo, Dominic C. Babbini, Allen G. Oliver, Toni L. O. Barstis|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277ybs
title: CCDC 2063215: Experimental Crystal Structure Determination

description: Related Article: Yu Xiong|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc277ydv
title: CCDC 2063217: Experimental Crystal Structure Determination

description: Related Article: Yu Xiong|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278djg
title: CCDC 2063655: Experimental Crystal Structure Determination

description: Related Article: Abdulrahman A. Alsimaree, Julian G. Knight, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278dkh
title: CCDC 2063656: Experimental Crystal Structure Determination

description: Related Article: Abdulrahman A. Alsimaree, Julian G. Knight, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278dmk
title: CCDC 2063658: Experimental Crystal Structure Determination

description: Related Article: Ahmed Alwaaly, Richard A. Henderson, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278dnl
title: CCDC 2063659: Experimental Crystal Structure Determination

description: Related Article: Thaer M. M. Al-Rammahi, Richard A. Henderson, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278dpm
title: CCDC 2063660: Experimental Crystal Structure Determination

description: Related Article: Thaer M. M. Al-Rammahi, Richard A. Henderson, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278dqn
title: CCDC 2063661: Experimental Crystal Structure Determination

description: Related Article: Thaer M. M. Al-Rammahi, Richard A. Henderson, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278drp
title: CCDC 2063662: Experimental Crystal Structure Determination

description: Related Article: Thaer M. M. Al-Rammahi, Richard A. Henderson, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278dsq
title: CCDC 2063663: Experimental Crystal Structure Determination

description: Related Article: Thaer M. M. Al-Rammahi, Richard A. Henderson, Paul G. Waddell|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278klp
title: CCDC 2063812: Experimental Crystal Structure Determination

description: Related Article: Xiaoming He|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278l26
title: CCDC 2063827: Experimental Crystal Structure Determination

description: Related Article: Józef Utko, Tadeusz Lis|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278l37
title: CCDC 2063828: Experimental Crystal Structure Determination

description: Related Article: Józef Utko, Tadeusz Lis|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278l48
title: CCDC 2063829: Experimental Crystal Structure Determination

description: Related Article: Józef Utko, Tadeusz Lis|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc278l59
title: CCDC 2063830: Experimental Crystal Structure Determination

description: Related Article: Józef Utko, Tadeusz Lis|2021|CSD Communication|||
DOI: 10.3886/e143102v1-89340
title: How Does Trade Respond to Anticipated Tariff Changes? Evidence from NAFTA

description: Firms anticipate upcoming tariff changes by shifting their purchases to periods with lower costs. This paper shows that such anticipatory dynamics overstate the trade elasticity. Standard identification of the trade response to trade cost changes uses tariff variation from Free Trade Agreements (FTA) and assumes that trade flows equal their consumption. However, FTAs eliminate tariffs gradually through announced phaseouts. This allows firms to delay their purchases until tariff cuts are effective while consuming their inventories. Indeed, during NAFTA's staged tariff reductions, imports experienced sizable \textit{anticipatory slumps} followed by \textit{liberalization bumps}. To study the behavior of consumed imports we construct a measure that uses inventory-sales ratios to smooth out trade flows. Its application to the data yields that the annual trade-flow elasticity is 56% larger than the trade-consumption response and that the ratio of the long- to short-run elasticity increases from 2.3 with trade flows to 3.4 with consumed imports. The measure is validated through Monte Carlo simulations of a (s,S) ordering model that reproduces the observed trade pattern.
DOI: 10.7488/191f40bd-ace9-4c8a-a36c-43b796303166
title: School staff’s, healthcare professionals’ and policymakers’ views of asthma and school-based asthma programme for primary school children: A qualitative study in Malaysia

description: 21 pdf files (de-identified transcripts and participants’ characteristics) ## Access ## This dataset is held in the Edinburgh DataVault, directly accessible only to authorised University of Edinburgh users. Academic researchers may request access, and will be required to sign a data sharing agreement.
description: Asthma is the commonest non-communicable disease among children potentially requiring urgent treatment during school hours, an important exemplar for school-based programmes. We conducted a qualitative study aimed to explore the views of school staff, healthcare professionals and policymakers, about asthma and school asthma programmes for primary school children. Purposive sampling was used to obtain diverse views from stakeholders in the education and health sectors in Malaysia. We used piloted semi-structured topic guides to conduct focus groups and individual interviews and completed data collection until we reached data saturation. The focus groups and interviews were audio-recorded, transcribed verbatim and analysed using inductive thematic analysis. Fifty-two participants (40 school staff, 9 healthcare professionals and 3 policymakers) contributed to nine focus groups and eleven individual interviews. The data in the Datavault contains 20 de-identified original transcripts and one de-identified file containing the characteristics of participants. We translated Malay (source language) to English and provided both languages in the transcripts. From our analysis, we found that school staff had limited awareness of asthma and first-aid asthma treatments. There was no guidance on asthma management in government schools, and teachers were unclear about their role in school children’s health. These uncertainties led to delays in treating asthma symptoms/attacks, and participants suggested that an asthma education programme and a school plan would improve asthma care. Perceived challenges in conducting school health programmes included a busy school schedule and poor parental participation. A tailored asthma programme developed in partnership with schools and health services could facilitate adoption/ and implementation. In conclusion, identifying and addressing issues and challenges specific to the school and broader community would facilitate a school asthma programme in line with the WHO School Health Initiative. Clarity over national policy on the role and responsibilities of school staff could support implementation and guide appropriate and prompt response to asthma emergencies in schools.
DOI: 10.24341/tethys.39
title: Geodaten - Blatt 76 Wiener Neustadt (1:50.000)
title: Geodata - sheet 76 Wiener Neustadt (1:50.000)

description: Die Geodaten wurden aus dem Kartenwerk GK50 „Geologische Karte der Republik Österreich 1:50.000“ abgeleitet. Die Datengrundlage basiert auf einer umfassenden Datenerhebung im Rahmen der gesetzlich verankerten geologischen Landesaufnahme von Österreich, welche eine umfangreiche Literaturrecherche, die Geländekartierung, sowie die Probenahme mit wissenschaftlichen Analysen und Messungen beinhaltet. Die im BMN-Blattschnitt veröffentlichten Geodaten entsprechen dem aktuellen Wissensstand zum Zeitpunkt des Kartendruckes und können geringfügig von den Originalen abweichen.
description: Die vorliegende Datenpublikation ist ein Bestandteil der Kartenserie „Geologische Karte der Republik Österreich 1:50.000“ (GK50), die im Zeitraum zwischen 1977 und 2017 veröffentlicht wurden und aus insgesamt 89 Geodatensätzen besteht. Eine ausführliche Datenbeschreibung wird mit den Kartendaten bereitgestellt und kann direkt zu jeder Publikation heruntergeladen werden.
description: This data publication is part of the map series "Geological Map of the Republic of Austria 1:50.000" (GK50), published between 1977 and 2017 consisting of 89 spatial data sets. A detailed data description is provided with the map data and can be downloaded together with the data publication.