DOI: 10.5281/zenodo.844849
title: Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve

description: Dataset containing the recorded and simulated data reported in the manuscript "Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve" published in the Journal of the Association for Research in Otolaryngology, JARO (https://doi.org/10.1007/s10162-019-00721-7):


	RECORDED Envelope Following Responses (EFR) in normal-hearing (NH) threshold and hearing-impaired (HI) human listeners using deeply (m = 85%) and shallowly (m = 25%) modulated sinusoidally amplitude modulated (SAM) tones.
	SIMULATED EFRs using the auditory nerve (AN) model by Zilany et al. (2009, 2014).


Files content and structure:

<strong>Recorded EFRs</strong>

<strong>Fig. 2:</strong>


	<em>fig2__recorded_efr.csv</em>:                      <br>
	EFR recordings as a function of stimulus level (EFR magnitude-level functions) for the NH and HI listeners using two modulation depths.


The file containing the recorded EFR data have the following columns:


	<em>lvl</em>:                             Stimulation level
	<em>m85_ok:                    </em>EFR magnitude (dB re to 1 µV) using m = 85%. Significant responses (F-test = 1)
	<em>m85_ko:                    </em>EFR magnitude (dB re to 1 µV) using m = 85%. Non-significant responses (F-test = 0)
	<em>m85_bkg:                  </em>Estimated background noise magnitude (dB re to 1 µV) for the recordings when m = 85%
	<em>m25_ok:                    </em>EFR magnitude (dB re to 1 µV) using m = 25%. Significant responses (F-test = 1)
	<em>m25_ko:                    </em>EFR magnitude (dB re to 1 µV) using m = 25%. Non-significant responses (F-test = 0)
	<em>m25_bkg:                  </em>Estimated background noise magnitude (dB re to 1 µV) for the recordings when m = 25% 
	<em>subj:                          </em>Listener id
	hearing:                     Hearing group (nh | hi) of the listener


<strong>Simulated EFRs:</strong>

<strong><em>Files with the simulation results summing across frequency and SR fiber type</em></strong>

<strong>Fig. 4:</strong>


	<em>fig4a__simul_efr__nh_23ohc_13ihc__no_cs.csv</em>:                       <br>
	Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4a).
	<em>fig4b__simul_efr__nh_slp_thres_all_ohc__no_cs.csv</em>:              <br>
	Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of OHC loss (Fig. 4b).
	<em>fig4c__simul_efr__nh_slp_thres_all_ihc__no_cs.csv</em>:               <br>
	Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of IHC loss (Fig. 4c).
	<em>fig4d__simul_efr__hi_23ohc_13ihc__no_cs.csv</em>:                       <br>
	Simulated EFR magnitude-level function for the HI listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).
	<em>fig4e__simul_efr__hi_all_ohc__no_cs.csv</em>:                               <br>
	Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming all of OHC loss (Fig. 4e).
	<em>fig4f__simul_efr__hi_all_ihc__no_cs.csv</em>:               <br>
	Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming all of IHC loss (Fig. 4f).
	<em>fig4g__simul_efr__hi_slp_thres_23ohc_13ihc__no_cs.csv</em>:                       <br>
	Simulated EFR magnitude-level function for the HI listeners (average) assuming sloping threshold at EHF and 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).
	<em>fig4h__simul_efr__hi_slp_thres_all_ohc__no_cs.csv</em>:                               <br>
	Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF and all of OHC loss (Fig. 4e).
	<em>fig4i__simul_efr__hi_slp_thres_all_ihc__no_cs.csv</em>:               <br>
	Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF and and all of IHC loss (Fig. 4f).


 

<strong>Fig. 5:</strong>


	<em>fig5a__simul_efr__nh__cs_ms_ls_100p.csv</em>:                              <br>
	Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming cochlear synaptopathy (CS) of a 100% of loss of only medium- and low-spontaneous rate (SR) AN fibers (Fig. 5a).
	<em>fig5b__simul_efr__nh09_cs__approx</em>.<em>csv</em>:            <br>
	Simulated EFR magnitude-level function to approximate the data for the NH threshold listener NH09 including CS (Fig. 5b).
	<em>fig5c__simul_efr__hi04_cs__approx</em>.<em>csv</em>:  <br>
	Simulated EFR magnitude-level function to approximate the data for the HI listener HI04 including CS (Fig. 5c).


 

<strong>Fig. 6:</strong>

Files with the simulation results for the NH threshold listener in different characteristic frequency (CF) bands and SR fiber types


	<em>fig6__simul_efr__nh_cf_band_analys__no_cs__m12.mat</em>:          <br>
	Simulated EFR magnitude-level function for the NH using a SAM tone with m = 12%.
	<em>fig6__simul_efr__nh_cf_band_analys__no_cs__m25.mat</em>:          <br>
	Simulated EFR magnitude-level function for the NH using a SAM tone with m = 25%.
	<em>fig6__simul_efr__nh_cf_band_analys__no_cs__m50.mat</em>:          <br>
	Simulated EFR magnitude-level function for the NH using a SAM tone with m = 50%.
	<em>fig6__simul_efr__nh_cf_band_analys__no_cs__m85.mat</em>:          <br>
	Simulated EFR magnitude-level function for the NH using a SAM tone with m = 85%.
	<em>fig6__simul_efr__nh_cf_band_analys__no_cs__m100.mat</em>:        <br>
	Simulated EFR magnitude-level function for the NH using a SAM tone with m = 100%.


 

<strong>Fig. 7:</strong>


	<em>fig7a__simul_efr__bw_analys__32oct_[20, 40, 60, 80, 100]p.csv</em>:                              <br>
	Simulated EFR magnitude-level function for the NH threshold listeners assuming CS of a bandwidth (BW) of 3/2-octave for a loss of AN fibers ranging from 20% to 100% (Fig. 7a).
	<em>fig7b__simul_efr__bw_analys__1oct_[20, 40, 60, 80, 100]p.csv</em>:            <br>
	Simulated EFR magnitude-level function for the NH threshold listeners assuming CS of a bandwidth (BW) of 1-octave for a loss of AN fibers ranging from 20% to 100% (Fig. 7b).
	<em>fig7c__simul_efr__bw_analys__13oct_[20, 40, 60, 80, 100]p.csv</em>:<br>
	Simulated EFR magnitude-level function for the NH threshold listeners assuming CS of a bandwidth (BW) of 1/3-octave for a loss of AN fibers ranging from 20% to 100% (Fig. 7c).


 

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The structure of the .csv files that contain the EFR simulations is:


	<em>lvl</em>:                          Stimulation level
	<em>mgn_mxxx:            </em>Simulated EFR magnitude (a.u. in dB) for each modulation depth (100%, 85%, 50%, 25% and 12%)
	<em>bkg_mxxx:             </em>Estimate of the background noise floor (a.u. in dB) for each modulation depth. 
	<em>ftest_mxxx:            </em>Result of the F-test statistical test (0 or 1) for each modulation depth.


 

The structure of the .mat files that contain the EFR simulations is:


	<em>exper_type</em>:           Name of the simulated experiment
	<em>species</em>:                 Species used in the AN model (in this study is always 2: human)
	<em>species_age</em>:         (Not used in this work). Age of the animal when species is 4: mouse
	modulation<em>:            </em>Modulation depth of the SAM tone used in the simulation <em>(100%, 85%, 50%, 25% or 12%)</em>
	<em>f_on:                      </em>Center frequency of the on-frequency band (<em>2000 Hz</em>)
	<em>f_off_hf:                 </em>Center frequency of the first off-frequency band (<em>3000 Hz</em>)
	<em>f_off_vhf:               </em>Center frequency of the second off-frequency band (<em>7000 Hz</em>) 
	<em>f_off_uvhf:             </em>Center frequency of the third off-frequency band (<em>12000 Hz</em>)
	<em>lvl_vect:                 </em>Stimulus level vector <em>(from 5 to 100 dB SPL, in steps of 5 dB)</em>
	<em>simul_efr             </em>  Structure with the simulated data
	
		The data structure contains many fields which are matricies of size 3x20. The columns are the 20 stimulus levels defined in <em>lvl_vect</em>, and the first row is the simulated EFR, the second row is the estimates background noise floor in the simulation, and the third row is the output of the F-test statistics.
		The structure fields can be divided in 4 groups:
		
			<em>ihc_</em>           Responses from the IHC (not shown in the paper)
			<em>an_hs_</em>      Responses from the High-SR fibers in the AN
			<em>an_ms_</em>     Responses from the Medium-SR fibers in the AN
			<em>an_ls_</em>       Responses from the Low-SR fibers in the AN
		
		
		Each group has 5 responses corresponding to the on-frequency band (<em>_on</em>) and the three off-frequency bands (<em>_off_hf</em>, <em>_off_vhf</em>, <em>_off_uvhf</em>); and the sum across frequencies (<em>_across_f</em>)
description: Funding: Oticon Centre of Excellence for Hearing and Speech Sciences (CHeSS) at the Technical University of Denmark (DTU) and Erasmus Mundus Student Exchange Network in Auditory Cognitive Neuroscience.