cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10352375.v1
title: Global similarity and local differences in Campylobacter jejuni lineages associated with asymptomatic paediatric infection from the Peruvian Amazon

description: <i>Campylobacter</i> is the leading bacterial cause of gastroenteritis worldwide and despite high incidence in low- to middle-income countries, where infection can be fatal, surveillance is rare and the genotypes responsible for disease have not been identified. The epidemiology of disease is different to the developed world, where infection is mostly associated with consumption of contaminated meat products. Infection is endemic among children and asymptomatic carriage is thought to be common. Widespread malnutrition encourages asymptomatic colonisation stunting childhood growth, leading to poor cognitive and physical development. Here, we sequence the genomes of a collection of <i>C. jejuni</i> isolates sampled from children in the Peruvian Amazon to investigate genetic differences between them and a global reference collection. In addition to common global disease lineages, we identified local genotypes rarely seen before. Asymptomatic isolates were not restricted to specific ecological groups or genotypes and chicken was the primary source of infection. Hidden reservoirs of bacterial diversity can help us understand the genetics underlying differences in the presentation of disease and will inform work to improve infant health globally.<br>
DOI: 10.6084/m9.figshare.10347839.v1
title: All data files and processing script of "Anhydrite-assisted hydrothermal metal transport to the ocean floor – insights from thermo-hydro-chemical modeling"

description: Data files and processing script.
DOI: 10.6084/m9.figshare.10347062.v2
title: "Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker Zap" - Source Data

description: In this work, we used an in vitro reconstitution approach to study how the well-conserved protein ZapA affects FtsZ treadmilling and filament organization into large-scale patterns. Using high-resolution fluorescence microscopy and quantitative image analysis, we found that ZapA cooperatively increases the spatial order of the filament network, but binds only transiently to FtsZ filaments and has no effect on filament length and treadmilling velocity. Together, our data provides a model for how FtsZ-associated proteins can increase the precision and stability of the bacterial cell division machinery in a switch-like manner.
DOI: 10.6084/m9.figshare.10352375.v2
title: Global similarity and local differences in Campylobacter jejuni lineages associated with asymptomatic paediatric infection from the Peruvian Amazon

description: <i>Campylobacter</i> is the leading bacterial cause of gastroenteritis worldwide and despite high incidence in low- to middle-income countries, where infection can be fatal, surveillance is rare and the genotypes responsible for disease have not been identified. The epidemiology of disease is different to the developed world, where infection is mostly associated with consumption of contaminated meat products. Infection is endemic among children and asymptomatic carriage is thought to be common. Widespread malnutrition encourages asymptomatic colonisation stunting childhood growth, leading to poor cognitive and physical development. Here, we sequence the genomes of a collection of <i>C. jejuni</i> isolates sampled from children in the Peruvian Amazon to investigate genetic differences between them and a global reference collection. In addition to common global disease lineages, we identified local genotypes rarely seen before. Asymptomatic isolates were not restricted to specific ecological groups or genotypes and chicken was the primary source of infection. Hidden reservoirs of bacterial diversity can help us understand the genetics underlying differences in the presentation of disease and will inform work to improve infant health globally.<br>
DOI: 10.6084/m9.figshare.10347839.v2
title: All data files and processing script of "Anhydrite-assisted hydrothermal metal transport to the ocean floor – insights from thermo-hydro-chemical modeling"

description: Data files and processing script.
DOI: 10.6084/m9.figshare.10352375.v3
title: Global similarity and local differences in Campylobacter jejuni lineages associated with asymptomatic paediatric infection from the Peruvian Amazon

description: <i>Campylobacter</i> is the leading bacterial cause of gastroenteritis worldwide and despite high incidence in low- to middle-income countries, where infection can be fatal, surveillance is rare and the genotypes responsible for disease have not been identified. The epidemiology of disease is different to the developed world, where infection is mostly associated with consumption of contaminated meat products. Infection is endemic among children and asymptomatic carriage is thought to be common. Widespread malnutrition encourages asymptomatic colonisation stunting childhood growth, leading to poor cognitive and physical development. Here, we sequence the genomes of a collection of <i>C. jejuni</i> isolates sampled from children in the Peruvian Amazon to investigate genetic differences between them and a global reference collection. In addition to common global disease lineages, we identified local genotypes rarely seen before. Asymptomatic isolates were not restricted to specific ecological groups or genotypes and chicken was the primary source of infection. Hidden reservoirs of bacterial diversity can help us understand the genetics underlying differences in the presentation of disease and will inform work to improve infant health globally.<br>
DOI: 10.6084/m9.figshare.10352375.v4
title: Global similarity and local differences in Campylobacter jejuni lineages associated with asymptomatic paediatric infection from the Peruvian Amazon

description: <i>Campylobacter</i> is the leading bacterial cause of gastroenteritis worldwide and despite high incidence in low- to middle-income countries, where infection can be fatal, surveillance is rare and the genotypes responsible for disease have not been identified. The epidemiology of disease is different to the developed world, where infection is mostly associated with consumption of contaminated meat products. Infection is endemic among children and asymptomatic carriage is thought to be common. Widespread malnutrition encourages asymptomatic colonisation stunting childhood growth, leading to poor cognitive and physical development. Here, we sequence the genomes of a collection of <i>C. jejuni</i> isolates sampled from children in the Peruvian Amazon to investigate genetic differences between them and a global reference collection. In addition to common global disease lineages, we identified local genotypes rarely seen before. Asymptomatic isolates were not restricted to specific ecological groups or genotypes and chicken was the primary source of infection. Hidden reservoirs of bacterial diversity can help us understand the genetics underlying differences in the presentation of disease and will inform work to improve infant health globally.<br>
DOI: 10.6084/m9.figshare.10344524
title: SI Appendix

description: data for the SI Appendix
DOI: 10.6084/m9.figshare.10343747
title: Comorbidity associated with Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but does not affect the parasite cycle in mice

description: Ascariasis is considered the most neglected tropical disease, and is a major problem for the public health system. However, idiopathic pulmonary fibrosis (IPF) is a result of chronic extracellular deposition of matrix in the pulmonary parenchyma, and thickening of the alveolar septa, which reduces alveolar gas exchange. Considering the high rates of ascariasis and pulmonary fibrosis, we believe that these two diseases may co-exist and possibly lead to comorbidities. We therefore investigated the mechanisms involved in comorbidity of <i>Ascaris suum </i>(<i>A. suum</i>) infection, which could interfere with the progression of pulmonary fibrosis. In addition, we evaluated whether a previous lung fibrosis could interfere with the pulmonary cycle of <i>A. suum</i> in mice. The most important findings related to comorbidity in which <i>A. suum</i> infection exacerbated pulmonary and liver injury, inflammation and dysfunction, but did not promote excessive fibrosis in mice during the investigated comorbidity period. Interestingly, we found that pulmonary fibrosis did not alter the parasite cycle that transmigrated preferentially through preserved but not fibrotic areas of the lungs. Collectively, our results demonstrate that <i>A. suum</i> infection leads to comorbidity, and contributes to the aggravation of pulmonary dysfunction during pulmonary fibrosis, which also leads to significant liver injury and inflammation, without changing the <i>A. suum</i> cycle in the lungs.<br>
DOI: 10.6084/m9.figshare.10342145
title: Full RFID data for generating sociality data

description: The csv file is the full output of the RFID antennas that was used to generate the association and social network data for this paper.<br>The R Data file is the RFID data cleaned and simplified into the categories needed to run further analyses.<br>
DOI: 10.6084/m9.figshare.10342145.v1
title: Full RFID data for generating sociality data

description: The csv file is the full output of the RFID antennas that was used to generate the association and social network data for this paper.<br>The R Data file is the RFID data cleaned and simplified into the categories needed to run further analyses.<br>
DOI: 10.6084/m9.figshare.10344524.v2
title: SI Appendix

description: data for the SI Appendix
DOI: 10.6084/m9.figshare.10338413
title: Integration of pharmacological and CRISPR-Cas9 screens informs on drug mechanism of action in cancer cells

description: Systematic integrative analysis of pharmacological CRISPR-Cas9 screens revealed the mode-of-action of hundreds of anti-cancer drugs and protein interaction networks underpinning drug-response.
DOI: 10.6084/m9.figshare.10344524.v1
title: SI Appendix

description: data for the SI Appendix
DOI: 10.6084/m9.figshare.10338413.v1
title: Integration of pharmacological and CRISPR-Cas9 screens informs on drug mechanism of action in cancer cells

description: Systematic integrative analysis of pharmacological CRISPR-Cas9 screens revealed the mode-of-action of hundreds of anti-cancer drugs and protein interaction networks underpinning drug-response.
DOI: 10.6084/m9.figshare.10338341
title: Figure 9

description: data for the Figure 9
DOI: 10.6084/m9.figshare.10334927
title: Supporting data of the manuscript entitled “Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging”

description: The fMRI data generated for the study include 54 figures (PMNE group: 37 figures; control group: 17 figures). These data were analyzed with ALFF, ReHo and seed-based FC, respectively. Detailed demographic data of the PMNE group and control group were listed (Supplementary Tables S1 and S2). The raw data of ALFF and ReHo extracted from the significantly different brain regions between the two groups were also shown as Supplementary Information files (Supplementary Tables S3 and S4).
DOI: 10.6084/m9.figshare.10338341.v2
title: Figure 9

description: data for the Figure 9
DOI: 10.6084/m9.figshare.10338341.v1
title: Figure 9

description: data for the Figure 9
DOI: 10.6084/m9.figshare.10333667
title: TableS1-features-original-369

description: Values for each gene for each of 369 features used in paper:Non-Homology-Based Prediction of Gene Functions in maize <br>
DOI: 10.6084/m9.figshare.10334927.v1
title: Supplementary information of the manuscript entitled “Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging”

description: The fMRI data generated for the study include 54 figures (PMNE group: 37 figures; control group: 17 figures). These data were analyzed with ALFF, ReHo and seed-based FC, respectively. Detailed demographic data of the PMNE group and control group were listed (Supplementary Tables S1 and S2). The raw data of ALFF and ReHo extracted from the significantly different brain regions between the two groups were also shown as Supplementary Information files (Supplementary Tables S3 and S4).
DOI: 10.6084/m9.figshare.10333667.v1
title: TableS1-features-original-369

description: Values for each gene for each of 369 features used in paper:Non-Homology-Based Prediction of Gene Functions in maize <br>
DOI: 10.6084/m9.figshare.10333529
title: Eurostat data for immigrants integration (2010-2017)

description: These data covers indicators from the immigrants integration, from the Zaragoza Declaration indicators (2010). It includes data about social inclusion, employment, education and acquistion of citizenshp by foreigners in 10 selected countries of the European Union.
DOI: 10.17632/rj58z7xjv2.2
title: Data for: Experimental and numerical analysis of a cement based thermal energy storage system with a helical heat exchanger

description: The datasets presented here contain temporally highly resolved temperature measurements of cyclic charging/discharging experiments at 60 and 80°C within the water-saturated cementitious storage medium and the laboratory temperature, as well as measurements of the transient boundary conditions: the temperature in the inlet and outlet pipes and the flow rate of the circulating heat transfer fluid (water). In addition, the geometry and materials of the experimental setup of the laboratory-scale prototype are presented. The experimental data set can be used to determine the storage characteristics, i.e. quantities such as storage capacity, charging/discharging rates, energy efficiency as well as to determine the thermal losses of the storage module. The data sets are also useful for the validation of storage models like the one presented in Nordbeck et al [in revision] or related geothermal systems like borehole heat exchangers or energy piles with helical heat exchangers.
DOI: 10.6084/m9.figshare.10333475
title: dataset for the MuLBSTA score.xlsx

description: The dataset was used for the build-up of MuLBSTA score, predicting mortality rate of viral pneumonia. The dataset contains clinical information of 528 patients with viral pneumonia in Ruijin Hospital, Shanghai, China.
DOI: 10.6084/m9.figshare.10334927.v2
title: Supplementary information of the manuscript entitled “Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging”

description: The fMRI data generated for the study include 54 figures (PMNE group: 37 figures; control group: 17 figures). These data were analyzed with ALFF, ReHo and seed-based FC, respectively. Detailed demographic data of the PMNE group and control group were listed (Supplementary Tables S1 and S2). The raw data of ALFF and ReHo extracted from the significantly different brain regions between the two groups were also shown as Supplementary Information files (Supplementary Tables S3 and S4).
DOI: 10.6084/m9.figshare.10333475.v1
title: dataset for the MuLBSTA score.xlsx

description: The dataset was used for the build-up of MuLBSTA score, predicting mortality rate of viral pneumonia. The dataset contains clinical information of 528 patients with viral pneumonia in Ruijin Hospital, Shanghai, China.
DOI: 10.6084/m9.figshare.10333475.v3
title: dataset for the MuLBSTA score.xlsx

description: The dataset was used for the build-up of MuLBSTA score, predicting mortality rate of viral pneumonia. The dataset contains clinical information of 528 patients with viral pneumonia in Ruijin Hospital, Shanghai, China.
DOI: 10.6084/m9.figshare.10332314
title: Supplementary Material for: Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

description: A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19). The strain (LUMC16) was pigmented and hyperhemolytic. Stimulation of human primary cells with hyperhemolytic LUMC16 and STSS/NF-HH strains and pigment toxin resulted in a release of proinflammatory mediators, including tumor necrosis factor, interleukin (IL)-1β, and IL-6. In addition, LUMC16 induced blood clotting and showed factor XII activity on its surface, which was linked to the presence of the pigment. The expression of pigment was not linked to a mutation within the CovR/S region. In conclusion, our study shows that the hemolytic lipid toxin contributes to the ability of GBS to cause systemic hyperinflammation and interferes with the coagulation system.
DOI: 10.6084/m9.figshare.10333475.v2
title: dataset for the MuLBSTA score.xlsx

description: The dataset was used for the build-up of MuLBSTA score, predicting mortality rate of viral pneumonia. The dataset contains clinical information of 528 patients with viral pneumonia in Ruijin Hospital, Shanghai, China.
DOI: 10.6084/m9.figshare.10334927.v5
title: Supporting data of the manuscript entitled “Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging”

description: The fMRI data generated for the study include 54 figures (PMNE group: 37 figures; control group: 17 figures). These data were analyzed with ALFF, ReHo and seed-based FC, respectively. Detailed demographic data of the PMNE group and control group were listed (Supplementary Tables S1 and S2). The raw data of ALFF and ReHo extracted from the significantly different brain regions between the two groups were also shown as Supplementary Information files (Supplementary Tables S3 and S4).
DOI: 10.6084/m9.figshare.10334927.v4
title: Supporting data of the manuscript entitled “Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging”

description: The fMRI data generated for the study include 54 figures (PMNE group: 37 figures; control group: 17 figures). These data were analyzed with ALFF, ReHo and seed-based FC, respectively. Detailed demographic data of the PMNE group and control group were listed (Supplementary Tables S1 and S2). The raw data of ALFF and ReHo extracted from the significantly different brain regions between the two groups were also shown as Supplementary Information files (Supplementary Tables S3 and S4).
DOI: 10.6084/m9.figshare.10331774
title: Supplementary Material for: Long-Term Suppression of Disabling Tremor by Thalamic Stimulation in a Patient with Spinocerebellar Ataxia Type 2

description: The beneficial effect of thalamic deep brain stimulation (DBS) on action tremor has been reported in a few cases of spinocerebellar ataxia (SCA); however, several factors should be taken into account regarding the indication for DBS in advanced cases. We performed DBS of the ventral intermediate nucleus (Vim) of the thalamus for treatment of coarse action tremor in a patient with SCA2 (spinocerebellar ataxia type 2) in the wheelchair-bound stage. Although improvement of the tremor of the proximal part was incomplete, the patient regained substantial parts of daily functioning. The effect lasted for more than 6 years, and the suppression of tremor significantly contributed to maintaining the level of the patient’s expression into the bedridden stage. Vim DBS can be a treatment option for tremor in SCA patients, even in the advanced stage, as long as the tremor is depriving the patient of behavioral expression. As residual proximal tremor may hamper functional recovery, DBS of other targets or multi-targets should be further explored to attain a better outcome.
DOI: 10.6084/m9.figshare.10331663
title: Supplementary Material for: Patient-Centred Outcomes in Anaemia and Renal Disease: A Systematic Review

description: <b><i>Background:</i></b> Anaemia is a nearly universal complication of chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) have been demonstrated to improve clinical outcomes and quality of life (QOL) in renal patients with anaemia. Patient-reported outcome measures (PROMs) are increasingly being used to evaluate the patient-centred impact of medical therapy. Here, we describe a systematic review of studies that evaluated patient-centred outcomes (PCOs) in renal patients undergoing anaemia treatment. <b><i>Methods:</i></b> We conducted a search of Medline (Ovid), EMBASE (Ovid), PsychINFO, and CINAHL databases for studies published until March 2018 that investigated an intervention to treat anaemia in renal patients and used at least one PROM. We also performed a quality assessment for all included studies. Statistical analyses characterized each study, PROMs used, the quality of PCO reporting, and the association between haematological outcomes and PCOs. <b><i>Results:</i></b> Of the 3,533 studies identified in the database search, 21 met all eligibility criteria. Fourteen (67%) of the studies were randomized-controlled trials. Most studies (81%) investigated CKD patients, 14% investigated post-renal transplant patients and 5% assessed patients with heart disease on haemodialysis. The most common anaemia intervention, used in 95% of studies, was ESAs. Forty-three percent of studies utilized one PROM, most commonly the SF-36, a measure of QOL not specifically created for use in nephrology patients. About a third of studies selectively reported PROM subscales, rather than reporting all subscales. Notable biases among included studies included lack of blinding, selective outcome reporting, and lack of power estimates for PCOs. We did not find a statistically significant association between improvements in haemoglobin and QOL. <b><i>Conclusions:</i></b> Future studies employing anaemia and nephrology-specific PROMs and conducted with greater rigour, standardization in the research methods, and reporting of PCOs in renal populations will improve understanding of PCOs in this patient group and hopefully improve patient outcomes and experiences.
DOI: 10.6084/m9.figshare.10331774.v1
title: Supplementary Material for: Long-Term Suppression of Disabling Tremor by Thalamic Stimulation in a Patient with Spinocerebellar Ataxia Type 2

description: The beneficial effect of thalamic deep brain stimulation (DBS) on action tremor has been reported in a few cases of spinocerebellar ataxia (SCA); however, several factors should be taken into account regarding the indication for DBS in advanced cases. We performed DBS of the ventral intermediate nucleus (Vim) of the thalamus for treatment of coarse action tremor in a patient with SCA2 (spinocerebellar ataxia type 2) in the wheelchair-bound stage. Although improvement of the tremor of the proximal part was incomplete, the patient regained substantial parts of daily functioning. The effect lasted for more than 6 years, and the suppression of tremor significantly contributed to maintaining the level of the patient’s expression into the bedridden stage. Vim DBS can be a treatment option for tremor in SCA patients, even in the advanced stage, as long as the tremor is depriving the patient of behavioral expression. As residual proximal tremor may hamper functional recovery, DBS of other targets or multi-targets should be further explored to attain a better outcome.
DOI: 10.6084/m9.figshare.10330688
title: Dataset and code for "Quantifying irrigation cooling benefits to maize yield in the US Midwest"

description: Dataset and code for paper "Quantifying irrigation cooling benefits to maize yield in the US Midwest" by Li et al in Global Change Biology (DOI: 10.1111/gcb.15002).<br>Contact: Yan Li, yanli.geo@gmail.com