cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/djm65zrhmt
title: Durable Cell and Gene Therapy Potential and Financial Impact

description: Supporting data for Young CM, Quinn C, Trusheim MR, "Durable Cell and Gene Therapy Potential Patient and Financial Impact: US Projections of Product Approvals, Patients Treated, and Product Revenues", Drug Discovery Today, September 17, 2021. Available from: https://doi.org/10.1016/j.drudis.2021.09.001
The data is described in Young CM, Quinn C, Trusheim MR, "Data for Modelling US Projections of Product Approvals, Patients Treated, and Product Revenues for Durable Cell and Gene Therapies ", Data in Brief, Submitted Sep 21, 2021.

Taking the pipeline of clinical trials for durable cellular and gene therapy products at December 31, 2020 as a starting point, we use a Markov Chain Monte Carlo model to estimate a distribution for US FDA marketing approvals for those products. Further, using epidemiological data and estimated prices, we infer distributions for total patients treated and revenues generated.

The data presented includes forecasting data (FD), parameter estimation data (PED), and supplementary data (SS).

Forecasting data comprises the set of clinical trials used in our forecasts (FD1), a set of preclinical trials (FD2) (used for sensitivity analysis), estimates of the relative prevalence of genes or antigens associated with specific diseases (FD3), and estimates of the treatable incidence and prevalence for those diseases (FD4). FD4 also includes our assumptions regarding the potential market penetration and adoption rates for approved products.

Parameter estimation data comprises clinical trials data for specific products in four categories: chimeric antigen receptor T-cells (CAR-Ts) and T-cell receptors (TCRs) (PED1); other oncology (PED2); gene therapy (PED3); cellular therapy (PED4). These data are used to estimate "time in phase" and "trial success rates", the stochastic parameters used in our Markov Chain model.

Supplementary File S1 contains a bibliography organized by disease and, within diseases, by antigen or gene.
Supplementary File S2 contains examples of code (mostly SQL) used to extract and process data from the Clinical Trials Transformation Initiative's database for Aggregate Analysis of ClinicalTrials.gov (AACT). (AACT is a dynamic entity and was substantially changed on November 15, 2021.)
Supplementary File S3 contains participant inclusion and exclusion criteria for clinical trials in our sample.
Supplementary file S4 is an Excel workbook containing code useful for extracting NCT identifiers from Pharmaprojects data.

Clinical trials data in FD1 were extracted from the NIH/FDA ClinicalTrials.gov database. http://www.clinicaltrials.gov
Preclinical data in FD2 were identified using Informa PLC. Pharmaprojects, published 2021. https://pharmaintelligence.informa.com/products-and-services/data-and-analysis/ pharmaprojects
Clinical trials in the parameter estimation datasets (PED1-4) were identified using Informa PLC. Pharmaprojects, published 2021. Data for the identified trials were extracted from AACT.
DOI: 10.17632/hwzbvmxnk6
title: FFT Based Multiband Spectrum Sensing in SIMO In-band Full-Duplex Cognitive Radio Networks

description: The presented file represents matlab code for FFT Based Multiband Spectrum Sensing in SIMO In-band Full-Duplex Cognitive Radio Networks. Basically the plot shows the probability of detection versus probability of false alarm with constant window lengths in time domain and frequency domain respectively. The modulation scheme used is BPSK OFDM. The far end ie. desired channels are modeled as multipath Rayleigh fading with 3 channel taps each.
DOI: 10.6084/m9.figshare.12660467.v2
title: Pedestrian network attributes-- Datasets

description: Title: Attributing pedestrian networks with semantic information based on multi-source spatial dataAbstract: The lack of associating pedestrian networks, i.e., the paths and roads used for non-vehicular travel, with information about semantic attribution is a major weakness for many applications, especially those supporting accurate pedestrian routing. Researchers have developed various algorithms to generate pedestrian walkways based on datasets, including high-resolution images, existing map databases, and GPS data; however, the semantic attribution of pedestrian walkways is often ignored. The objective of our study is to automatically extract semantic information including incline values and the different categories of pedestrian paths from multi-source spatial data, such as crowdsourced GPS tracking data, land use data, and motor vehicle road (MVR) networks. Incline values for each pedestrian path were derived from tracking data through elevation filtering using wavelet theory and a similarity-based map-matching method. To automatically categorize pedestrian paths into five classes including sidewalk, crosswalk, entrance<i> </i>walkway, indoor path<i>,</i> and greenway, we developed a hierarchical strategy of spatial analysis using land use data and MVR networks. The effectiveness of our proposed method is demonstrated using real datasets including GPS tracking data collected by volunteers, land use data acquired from OpenStreetMap, and MVR network data downloaded from Gaode Map.
DOI: 10.6084/m9.figshare.19617648.v2
title: Source Data for Savinov et al. 2022: protein fragment mapping

description: Source Data and higher-resolution figure files associated with the following article: A. Savinov, A. Fernandez, S. Fields. Mapping functional regions of essential bacterial proteins with dominant-negative protein fragments. <em>Proc. Natl. Acad. Sci. U.S.A.</em> <strong>119</strong> (26) e2200124119 (2022). https://doi.org/10.1073/pnas.2200124119. Please cite this article if you make use of these data.
DOI: 10.6084/m9.figshare.21523521.v1
title: Character Dataset (DSchar10k)

description: The dataset Dissected Scene Characters 10k (DSChars10k ) contains 10,256 dissected character images. All images are alphabets with 52 classes, i.e., 26 classes for uppercase (A-Z) and another 26 classes for lowercase (a-z) characters. All character images are camera captured and Roman script. The dimension of all dissected character images is unequal. This dataset contains only 52 classes(alphabets only). All individual classes have an uneven number of samples.
DOI: 10.6084/m9.figshare.11550600.v2
title: Impact of stress on zebrafish behaviour

description: Impact of acute and chronic stress on swimming speed (sheet 1); time spent at the bottom of the tank (sheet) and fractal dimension (FD, sheet 3) where fish had no stress, acute or chronic stress and subject to no disturbance (control), anaesthesia and handling (Sham) and anaesthesia and fin clip. Acutely stressed controls and fin clip fish were subject to naloxone administration.Published in Journal of Experimental Biology (2020) 223, jeb224527. doi:10.1242/jeb.224527<br>
DOI: 10.60893/figshare.apl.28735070.v1
title: Supplemental Material (The most recently revised, unmarked version)

description: More details on computational methods, phonon dispersion, band structures, spin textures and analysis of intrinsic electric field.
DOI: 10.6084/m9.figshare.22899983.v1
title: Occurrences of pollinator species

description: A table with the Order, Family, Genus and species epithet of the 1730 species with at least one GBIF record. A column gives the number of records, and another the number of records left after cleaning the data.
DOI: 10.6084/m9.figshare.28779680.v1
title: Sample SRR3414629

description: Investigating the differential expression the reprogrammed and control in mouse
DOI: 10.6084/m9.figshare.21646703.v1
title: data MK and VOCs chicken preen gland

description: Raw data comprising relative proportion of FAs and VOCs in chicken preen secretions for two genotypes - Ross 308 and ISA Dual. Dataset categories are ID, SEX, GENOTYPE and experimental BOX (littered poultry pen) identity + relative proporitons of SFA, MUFA and PUFA + particular most dominant FAs. VOCs database comprises the same variable categories. For identity of partcular VOCs appeare as VAR_1, VAR_2 etc. will be provided on the request of the author (V. Gvozdikova Javurkova).
DOI: 10.6084/m9.figshare.24282451.v2
title: Sexual conflict: the fitness cost of traumatic insemination, female avoidance, and male mate choice

description: <b>Experiment 1: Female fitness</b>Code for analyses and visualization for egg and hatchling data are in the analyses_markdown files. Code for analyses and visualization for female longevity is in the longevity_analyses.R file in the scripts folder.<b>Experiment 2: Female insemination status</b>Everything is located in the female_insem_status folder Code for analyses and visualization: In scripts folder File name: observations_analysis.R Code for creating network visualizations: In scripts folder File name: sexual_networks.R The igraphplot2.R script is just for modifying some network aesthetic properties. It's used in the sexual_networks.R file<b>Experiment 3: Successive traumatic inseminations</b>Everything is also located in the analyses_markdown files.<br><br><b>All the same data and code is also available at the below GitHub link. </b>
DOI: 10.6084/m9.figshare.16511568.v1
title: FSMol Baseline Models

description: Baseline Model Weights for the FSMOL benchmark.<br>Accompanying code is available on github: https://github.com/microsoft/FS-Mol/
DOI: 10.6084/m9.figshare.26978050.v2
title: GVHD RAG Data with Production

description: A classic retrieval augmented generation (RAG) Q&A bot that answers questions about the GVHD medical condition.
DOI: 10.6084/m9.figshare.28714328.v1
title: DataCoSupplyChainDataset

description: DataCoSupplyChainDataset
DOI: 10.6084/m9.figshare.27201303.v3
title: List of SNPs found in Liberoid Meranti 1 and 2 samples and supplementary tables

description: List of SNPs found in Liberoid Meranti 1 and 2 samples. Use the following column names to distinguish the varieties:VH01787_14_AACHH5CHV_1_AGAGTCCA is Liberoid Meranti 1, plant 2 - 1_2VH01787_14_AACHH5CHV_1_AGGATAGC is Liberoid Meranti 2, plant 1 - 2_1VH01787_14_AACHH5CHV_1_CGATCGAT is Liberoid Meranti 2, plant 3 - 2_3VH01787_14_AACHH5CHV_1_GATCTTGC is Liberoid Meranti 2, plant 2 - 2_2VH01787_14_AACHH5CHV_1_GCTACTCT is Liberoid Meranti 1, plant 1 - 1_1 VH01787_14_AACHH5CHV_1_GTAGCGTA is Liberoid Meranti 1, plant 3 - 1_3
DOI: 10.6084/m9.figshare.27960840.v1
title: Cardiac performance data

description: <b>Variables in the dataset:</b><b>Coast:</b> Two coasts were samples for this dataset. The West coast was sampled at Namaqua National Park (NNP), the Southern coast at Garden Route National Park (GRNP).<b>Temperature:</b> Thermal treatments used for the acute thermal exposure of <i>S. capensis</i>. Five thermal treatments were used (24, 29, 34, 39, and 44ºC).<b>Cadmium:</b> Cadmium chloride (CdCl<sub>2</sub>) was used for the acute chemical exposure of <i>S. capensis</i>. Three concentrations were used: Control, Environmentally Relevant Concentration +10% (ERC +10%), and Environmentally Relevant Concentration +20% (ERC +20%).<b>Cardiac Performance (Heart rate):</b> The resultant heart rates of <i>S. capensis</i> per minute after acute chemical and thermal exposure. individual and average heart rates are included.
DOI: 10.25381/cput.27643668.v1
title: Kenya villages daily load data

description: This study addresses the issue of energy access in rural Kenya, where a significant portion of the population lacks electricity. The research focuses on designing renewable microgrids tailored to the specific renewable energy resources available in five selected villages: Mumbiri, South Korr, Kitulu, Mkwiro, and Sasimwani. The goal is to develop economically viable and sustainable energy solutions that meet these rural communities' electricity demand, improving their quality of life and reducing their dependence on traditional biomass-based energy sources.
DOI: 10.6084/m9.figshare.12925895.v1
title: Data for Delhey et al. Partial or complete? The evolution of post-juvenile moult strategies in passerine birds

description: <b>Variable descriptors for dataset</b> · TipLabel: scientific name matching taxonomy of www.birdtree.org · common.name: common name · tax.family: taxonomic family based on taxonomy at www.birdtree.org · post.juv.moult.score: extent of post juvenile moult where 0=partial, 1=partial or complete and 2=complete · post.juv.moult.complete: extent of post juvenile moult as binary variable where 0=partial, 1=partial or complete and complete · complete.moult.before.fst.breed: presence/absence of complete moult before the first breeding season, either through a complete post-juvenile moult or a complete nuptial moult. · moult.certainty.score: limited vs good · primary.moult.score: 0=partial, 1= complete · delay.plum.mat: delayed plumage maturation score · moult.source: reference for moult data · sexual.dichromatism: sexual dichromatism score · log.mass: log10 transformed body mass · perc.diet.seed: % of seed in diet · degrees.from.equator: absolute latitude of centroid of breeding distribution · mig.distance: migration distance · insolation: insolation value · annual.mean.temperature: annual mean temperature · annual.precipitation: annual precipitation · habitat.open: habitat openness score<br>
DOI: 10.6084/m9.figshare.26069647.v1
title: Word-Level Bangla Sign Language Gestures

description: This dataset includes 51 unique sign gestures for Bangla Sign Language words. The signs were performed by two signers. Each signer performed all the signs ten times, making the total number of videos in this dataset 1020 (51*2*10 videos).
DOI: 10.18742/25266595.v1
title: Data files supporting "<b>Do errors in the GHQ-12 response options matter?"</b>

description: <b>Background:</b><b> </b>The twelve item General Health Questionnaire (GHQ-12) is a widely used measure of psychological wellbeing. Because there are seven different sets of response options across the twelve items, there is scope for transcription errors to occur when researchers assemble their study materials. The impact of such errors might be more important if they occur in the first set of response options than if they occur later in the questionnaire, once participants have become aware that options to the right of the GHQ-12 response sets always indicate worse wellbeing.<b>Aims:</b><b> </b>To test the impact of introducing errors into the first and eighth set of response options for the GHQ-12 that render those response sets partially illogical.<b>Methods:</b><b> </b>We used a double-blind randomised controlled trial, pre-registered with Open Science Framework (osf.io/syhwf). Participants were recruited by a market research company from their existing panel of respondents in Great Britain. Participants were randomly allocated to receive one of three versions of the GHQ-12: a correct version (n=500), a version with a mistake in the first item (n=502), or a mistake in the eighth item (n=502). Mistakes replaced ‘better than usual’ (item one) or ‘more so than usual’ (item eight) with ‘not at all.’<b>Results:</b><b> </b>We found no differences between the versions in terms of number of participants with possible poor psychological wellbeing (χ<sup>2</sup>=0.32, df=2, p=0.85) or in mean GHQ-12 scores for the three groups (F(2, 1501)=0.26, p=0.77).<b>Conclusions:</b><b> </b>Small deviations from the standard GHQ-12 wording do not have a substantive impact on results.
DOI: 10.6084/m9.figshare.23275907.v1
title: Supplementary Material for: The European Portuguese Version of the Brief Negative Symptom Scale

description: Negative symptoms reflect a currently much-untreated loss of normal functioning and are frequently found in psychotic disorders. We present the first translation of the Brief Negative Symptom Scale (BNSS) to European Portuguese and evaluate its validity in a sample of Portuguese male patients with a psychotic spectrum disorder. The Portuguese BNSS showed excellent internal consistency, high convergent validity (i.e., strong correlation with the PANSS negative factor), and high discriminant validity (i.e., a lack of association with the PANSS positive factor). In sum, the present European Portuguese BNSS has shown to be reliable, thus extending this instrument’s clinical availability worldwide.
DOI: 10.5281/zenodo.15314430
title: Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to ⍺-synuclein – Source data

description: This file contains two tabs. The first one (Flow cytometry data) contains the acquired flow cytometry data used in the publication. The second tab (scRNAseq data), contains the cluster frequency of all samples analyzed by scRNAseq. See README file for more information.
DOI: 10.5281/zenodo.15314431
title: Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to ⍺-synuclein – Source data

description: This file contains two tabs. The first one (Flow cytometry data) contains the acquired flow cytometry data used in the publication. The second tab (scRNAseq data), contains the cluster frequency of all samples analyzed by scRNAseq. See README file for more information.
DOI: 10.17632/3d3mrkw8jr
title: Data for: Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson's Disease

description: Raw data for my manuscript submission
DOI: 10.6084/m9.figshare.19786465.v1
title: Supplementary Material for: Which Electronic Health Record System Should We Use? – A Systematic Review

description: The UK government had intended to introduce a comprehensive EHRs system in England by 2020. These EHRs would run across primary, secondary, and social care linking data in a single digital platform. This systematic review's objectives were to identify studies that compare EHRs in terms of direct comparison between systems and evaluate them using System and Software Quality Requirements and Evaluation (SQuaRE) ISO/IEC 25010. A systematic review was performed by searching EMBASE and Ovid MEDLINE databases between 1974 and April 2021. All original studies that appraised EHR systems and their providers were included. The main outcome measures were EHR system comparison and SQuaRE’s eight characteristics: functional suitability, performance efficiency, compatibility, usability, reliability, security, maintainability, and portability. A total of 724 studies were identified using the search criteria. After review of titles and abstracts, this was filtered down to 40 studies as per exclusion and inclusion criteria set out in our study selection. Seven studies compared more than one EHR. The following number of studies looked at the various aspects of the SQuaRE respectively. Nineteen studies addressed functional suitability, n=18 performance efficiency, n=12 compatibility, n=25 usability, n=6 reliability, n=2 security, n=16 maintainability, and n=13 portability. Epic was the most studied EHR system and one of the most implemented vendors in the USA market, and one of the top ten in UK. It is difficult to assess which is the most advantageous EHR system currently available when looking at them in accordance with SQuaRE’s eight characteristics for software evaluation.
DOI: 10.6084/m9.figshare.15131934.v1
title: New York Times News

description: New York Times news (15 March 2019-31 December 2019)
DOI: 10.6084/m9.figshare.24486394.v1
title: Supplementary Material for: Refractive management of surgical induced presbyopia in a young patient with vision-related quality of life complaints

description: Visual difficulties can negatively impact life quality. A 32-years-old woman, submitted to phacoemulsification with implantation of a monofocal intraocular lens (IOL) and Nd:YAG LASER posterior capsulotomy three years before, due to congenital cataracts, was referred to the Refractive Surgery Unit of Centro Hospitalar Universitário de Santo António. She had mixed astigmatism (+1.00-4.00x10°in the right eye and +0.50-1.75x180°in the left eye) and surgical-induced presbyopia, was intolerant to contact lenses, and felt that her vision significantly impaired her life quality. A trifocal Sulcoflex® (Rayner) IOL was implanted to correct the spherical and near refractive errors. In a second surgical time, a photorefractive keratectomy was performed to correct the residual astigmatism (-3.50x10º in the right eye and -1.50x170º in the left eye). In the last visit, distance and near uncorrected visual acuity were 20/20 (Snellen) and Jaeger 1, respectively, in both eyes, and the patient was very satisfied. When assessing the surgical options of young, working-age patients, clinicians should, when possible, consider alternative solutions to monofocal IOLs. In this patient, the combination of corneal and intraocular procedures allowed the correction of both the distance and near refractive errors, with a subsequent significant improvement in the patient’s quality of life.
DOI: 10.6084/m9.figshare.27200613.v1
title: Supplementary Material for: Alanyl-glutamine inhibits the epithelial-mesenchymal transition of airway epithelial cells in asthmatic mice via DPP4-Sirt1 pathway

description: Introduction: Alanyl-glutamine (Ala-Gln) is a compound known for its protective effects in various tissue injuries. However, its role in asthma-related lung injuries remains underexplored. This study investigates the mechanisms by which Ala-Gln modulates sDPP4-induced airway epithelial-mesenchymal transition and Ovalbumin (OVA)-induced asthma in a mouse model. 
Methods: An asthma model was established in female C57BL/6J mice by using OVA. CD4+ T cells and bronchial epithelial cells (BECs) were isolated from the spleen and bronchi of the mice, respectively. Interventions included recombinant sCD26/sDPP4 protein, Ala-Gln, and EX527 (a SIRT1 inhibitor). Flow cytometry was used to assess Th17 and Treg cell populations. Mice were treated with Ala-Gln, EX527, and budesonide (BUD). Histopathological changes in lung tissues were evaluated using hematoxylin-eosin and Masson staining. White blood cell counts were measured with a hematology analyzer. The expression levels of DPP4, IL-17, SIRT1, SMAD2/3, N-cadherin, E-cadherin, MMP9, and α-SMA proteins were analyzed.
Results: Treatment with recombinant sCD26/sDPP4 resulted in decreased E-cadherin expression in BECs and increased levels of α-SMA, MMP9, and N-cadherin, effects that were mitigated by Ala-Gln. Ala-Gln also prevented the reduction in SIRT1 expression in BECs and the increase in Th17 cell differentiation induced by recombinant sCD26/sDPP4. EX527 administration alongside Ala-Gln reversed these changes and enhanced the phosphorylation of SMAD2/3 through SIRT1 signaling. BUD alone reduced inflammation and fibrosis in bronchial tissue and lowered the Th17/Treg ratio in peribronchial lymph nodes. The therapeutic effect of BUD was further improved with concurrent Ala-Gln treatment. 
Conclusion: Ala-Gln can inhibit BEC fibrosis and Th17 cell differentiation mediated by recombinant sCD26/sDPP4 through the SIRT1 pathway. Combined with BUD, Ala-Gln enhanced therapeutic efficacy in OVA-induced asthma in mice, which could offer improved outcomes for asthmatic patients with elevated DPP4 levels.
DOI: 10.6084/m9.figshare.28597385.v1
title: Batemans Bay model output and observation data for model validation over June-August 2022

description: The attached Excel file contains data from FVCOM model and observations over the period June to August 2022. The data in file is as below (see also Figure 1&2 in the article for reference to places and detailed information of data): Hourly sea level at UD, PJ and BG. Hourly depth averaged meridional velocity at the ADCP station over the shelf. Hourly SWH and significant wave period at the wave-gauge site to the east of the bay mouth.