DOI: 10.7270/q2np27x5
title: BindingDB Entry 50010235: Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.

description: Small molecule binding data for protein 3-phosphoinositide-dependent protein kinase 1, 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1, Activin receptor type-1B, Angiopoietin-1 receptor, Aurora kinase B, Beta-adrenergic receptor kinase 1, Calcium/calmodulin-dependent protein kinase type IV, Casein kinase I isoform alpha, Casein kinase II subunit alpha, Cyclin-T1/Cyclin-dependent kinase 9, Cyclin-dependent kinase 2, Cyclin-dependent kinase 5 activator 1, Cyclin-dependent kinase 7, Cytoplasmic tyrosine-protein kinase BMX, Death-associated protein kinase 1, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity protein kinase CLK2, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Ephrin type-A receptor 3, Ephrin type-A receptor 8, Ephrin type-B receptor 2, Epidermal growth factor receptor, Fibroblast growth factor receptor 2, G protein-coupled receptor kinase 4, G protein-coupled receptor kinase 6, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Inhibitor of nuclear factor kappa-B kinase subunit beta, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Insulin receptor, Insulin-like growth factor 1 receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, Leucine-rich repeat serine/threonine-protein kinase 2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, MAP/microtubule affinity-regulating kinase 3, MAP/microtubule affinity-regulating kinase 4, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Misshapen-like kinase 1, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 13, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, NT-3 growth factor receptor, NUAK family SNF1-like kinase 1, Non-receptor tyrosine-protein kinase TYK2, PAS domain-containing serine/threonine-protein kinase, Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Protein kinase C iota type, Protein kinase C theta type, Protein kinase C zeta type, Protein-tyrosine kinase 6, Proto-oncogene tyrosine-protein kinase Src, RAC-alpha serine/threonine-protein kinase, RAC-beta serine/threonine-protein kinase, RAC-gamma serine/threonine-protein kinase, RAF proto-oncogene serine/threonine-protein kinase, Receptor tyrosine-protein kinase erbB-2, Receptor-type tyrosine-protein kinase FLT3, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Ribosomal protein S6 kinase alpha-3, Ribosomal protein S6 kinase beta-1, SRSF protein kinase 1, Serine/threonine-protein kinase 26, Serine/threonine-protein kinase B-raf, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase MRCK alpha, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase Nek4, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase PAK 1, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase pim-1, Sphingosine kinase 1, Testis-specific serine/threonine-protein kinase 1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase HCK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lck, Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, Vascular endothelial growth factor receptor 2, and cAMP-dependent protein kinase catalytic subunit alpha, Uniprot O00141, O00329, O14757, O14920, O15264, O15530, O60285, O60563, O60674, O75116, O96017, P00519, P00533, P04049, P04626, P04629, P06213, P06239, P07333, P08069, P08581, P08631, P10721, P11309, P12931, P15056, P17612, P21802, P23443, P23458, P24941, P25098, P27448, P27986, P28482, P29320, P29322, P29323, P29597, P31749, P31751, P32298, P35968, P36888, P36896, P41743, P43250, P43403, P43405, P45983, P45984, P48729, P49137, P49760, P49840, P49841, P50613, P50750, P51617, P51812, P51813, P51955, P51957, P52333, P52564, P53350, P53355, P54619, P68400, Q00535, Q02750, Q02763, Q04759, Q05513, Q06187, Q08881, Q13131, Q13153, Q13464, Q13627, Q13882, Q14164, Q15078, Q16288, Q16512, Q16539, Q16566, Q5S007, Q5VT25, Q8CIP4, Q8IW41, Q8N4C8, Q96GD4, Q96RG2, Q96SB4, Q9BXA7, Q9HC98, Q9NWZ3, Q9NYA1, Q9P289, Q9UHD2, Q9UL54, Q9Y243, and Q9Y478