cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5121289.v1
title: Supplementary Material for: M1 Protein-Dependent Intracellular Trafficking Promotes Persistence and Replication of <i>Streptococcus pyogenes</i> in Macrophages

description: <i>Streptococcus pyogenes</i> is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although <i>S. pyogenes</i> are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emphasized. In patients with deep tissue infections, an intracellular reservoir of <i>S. pyogenes</i> within macrophages was shown to contribute to prolonged bacterial persistence. Here we demonstrate that intracellular survival of <i>S. pyogenes</i> in macrophages is associated with an M1 protein-dependent intracellular trafficking in the phagosomal-lysosomal pathway, which results in impaired fusion with lysosomes. The phagocytic vacuoles harbouring M1 protein-expressing bacteria not only served as a safe haven for the bacteria, but also as a replicating niche. An M1 protein-dependent modulation of macrophages was further supported by differences in NF-ĸB signalling between cells infected with either the wild-type or M1 protein-deficient strains, thereby indicating a suppressed inflammatory response when M1 protein was involved. Evidence of egress of bacteria out of their host cell and subsequent re-infection of new cells emphasize the importance of intracellular bacteria as a reservoir for dissemination of infection and continued tissue injury.
DOI: 10.6084/m9.figshare.5718532.v1
title: Biomarkers as predictors of mortality in critically ill patients with solid tumors

description: ABSTRACT Biochemical markers produced by the affected organ or body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and mortality. The aim of this study is to analyze different biochemical markers in critically cancer patients and to determine which of them can be used as predictors of mortality. This is a prospective, cross-sectional study conducted at a University Hospital in Porto Alegre - RS. Screening was done to include patients in the study. Serum biochemical markers obtained in the first 24 hours of Intensive Care Unit hospitalization were analyzed. A second review of medical records occurred after three months objected to identify death or Unit discharged. A sample of 130 individuals was obtained (control group n = 65, study group n = 65). In the multivariate model, serum magnesium values OR = 3.97 (1.17; 13.5), presence of neoplasia OR = 2.68 (95% CI 1.13; 6.37) and absence of sepsis OR = 0.31 (95% CI 0.12; 0.79) were robust predictors of mortality. The association of solid tumors, sepsis presence and alteration in serum magnesium levels resulted in an increased chance of mortality in critically ill patients.
DOI: 10.6084/m9.figshare.5129281.v1
title: Supplementary Material for: Age-Dependent Impact of Medication Underuse and Strategies for Improvement

description: <b><i>Background:</i></b> Medication underuse is common in aging populations and, because of the growing risk for competing deaths, the benefit of preventive medicines gradually vanishes with advancing age, thus limiting their success. <b><i>Objective:</i></b> To estimate the optimum time of initiation of the secondary prevention of cardiovascular events, we examined the impact of appropriate pharmacotherapy for different starting ages at which it is implemented. <b><i>Methods:</i></b> In the competing risk framework, we obtained the population's life course from life tables, combined it with effect estimates quantifying the real-world effectiveness of secondary prevention, and compared the outcome of patients not receiving appropriate treatment (underuse) with those receiving preventive medicines that have demonstrated a reduction in the transition to serious cardiovascular events (START criteria). Starting at the age of 55 years, the population proportions of the distinct states of the framework were calculated for each year of chronological age in subgroups of appropriate treatment and underuse. These proportions were used over a follow-up period to estimate measures of treatment effectiveness and risks of underuse. <b><i>Results:</i></b> Despite increasing relative effectiveness with advancing age, benefits measured by patient-relevant endpoints, such as life years gained (LYG) or gained quality-adjusted life years (QALYs), markedly dropped after the starting age of 75 years, but even at an initiation age of 85 years, QALYs gained exceeded 1 year. <b><i>Conclusion:</i></b> Interventions targeting medication underuse may achieve considerable benefits at any stage of later life, while the benefit is probably largest if appropriate treatment is started before 75 years.
DOI: 10.6084/m9.figshare.12815660.v1
title: Absorption and fluorescence spectra of the main cyanobacterial pigments capture the spectral niches created by the harmonics of the water molecule

description: <br>Dataset accompanies <b>Fig. 3 </b>and <b>Extended Data Fig. 3.</b>
DOI: 10.6084/m9.figshare.24151437.v3
title: Supplementary Material for: Associations between differential aging and lifestyle, environment, current, and future health conditions: Findings from Canadian Longitudinal Study on Aging

description: Introduction: An aging population is a pressing challenge for the healthcare system. Insights into promoting healthy longevity can be gained by quantifying the biological aging process and understanding the roles of modifiable lifestyle and environmental factors and chronic disease conditions. 

Methods: We developed a biological age (BioAge) index by applying multiple state-of-art machine learning models based on easily accessible blood test data from the Canadian Longitudinal Study of Aging (CLSA). The BioAge gap, which is the difference between BioAge index and chronological age, was used to quantify the differential aging, i.e., the difference between biological and chronological age, of the CLSA participants. We further investigated the associations between the BioAge gap and lifestyle, environmental factors, and current and future health conditions. Results: BioAge gap had strong associations with existing adverse health conditions (e.g., cancers, cardiovascular diseases, diabetes, kidney diseases) and future disease onset (e.g., Parkinson's disease, diabetes, and kidney diseases). We identified that frequent consumption of processed meat, pork, beef, and chicken, poor outcomes in nutritional risk screening, cigarette smoking, exposure to passive smoking, are associated with positive BioAge gap (“older” than expected in BioAge index). We also identified several modifiable factors, including eating fruits, legumes, vegetables, related to negative BioAge gap (“younger” than expected in BioAge index). 

Discussion/Conclusions: Our study shows that a BioAge index based on easily accessible blood tests has the potential to quantify the biological aging process that is associated with current and future adverse health events. The identified risk and protective factors for differential aging indicated by BioAge gap are informative for guiding policy making to promote healthy longevity.
DOI: 10.6084/m9.figshare.875395.v1
title: Climate trajectories for 1960-2009: land

description: The file contains maps of climate trajectories derived from the velocity of climate change for 1960-2009 for global land areas. Methods follow: Velocity-derived trajectories to indicate global regions susceptible to effects of geographical limits to climate-driven distribution shifts. Climate trajectories are paths that points on an isotherm will travel over specific periods, integrating spatially variable speeds and directions of climate velocity along the way to show effects that static velocity maps cannot. Geographical limits to trajectories, either barriers such as coasts and mountains or lack of connections to cooler or warmer environments, suggest limits to climatic niche shifts and, by inference, local species persistence or replacement from warmer environments. Velocity fields were derived for 1960-2009 for land and ocean surface temperatures7 on a 1º grid, allowing inference at a global scale, but sacrificing small-scale detail. We categorized types of trajectory behaviour using trajectory length and the percentages of trajectories starting in, ending in and passing through cells. Short trajectories indicated non- or slow-moving thermal niches. Cells were classed as relative climate sinks if a high proportion of trajectories terminated there. Absolute climate sinks were also distinguished: coastal climate sinks where trajectories were blocked by coasts, and internal climate sinks where velocities in neighbouring cells converged. Cells were classed as climate sources if no trajectories ended there. Thereafter, cells with a high proportion of trajectories passing through were classed as corridors. Divergence cells were identified as those where fewer trajectories ended than started in that cell, and convergence cells if the opposite were true. Uncertainty evaluated by bootstrap resampling of annual average temperature maps gave a likely (&gt;66% consistency) designation of types for 59% of ocean and 72% of land cells. Consistency was &lt;66% where spatial gradients and temperature trends are most uncertain, such as where inter- and multidecadal climate variability dominates as for the El Niño-Southern Oscillation in the tropical Pacific. Very likely classification (&gt;90%) was achieved for 40% of land and 26% of ocean cells, mainly sources, coastal sinks and low velocity areas .
DOI: 10.6084/m9.figshare.9896201.v1
title: HLNb2_1.fq.gz

description: The sequence of bacteria in 10-20 cm native forest soil in Hulunbuir Sandy Land
DOI: 10.6084/m9.figshare.26355211.v1
title: Zizania latifolia Genome sequencing and assembly files

description: Zizania latifolia Genome sequencing and assembly
DOI: 10.6084/m9.figshare.28033790.v1
title: Prompts mHealth prototype

description: After the initial development of the GOALS system 2.0, the prototype was subjected to 4 rounds of iterative testing. Based on the adjusted GOALS rubric, the prompt changed in those iterations
DOI: 10.6084/m9.figshare.28651748.v1
title: Supplementary Material for: Neuroendoscopic Surgical Treatment of Cerebellar Vermis Tumors in Pediatric Patients : Case Series

description: To investigate the utility and experience of neuroendoscopy in the resection of cerebellar vermis tumors. Retrospective analysis was conducted on the clinical data of cerebellar vermis tumors treated with the German STORZ neuroendoscope within the Department of Neurosurgery at Guizhou Provincial People's Hospital and Guizhou Hospital of Shanghai Children's Center from January 2021 to January 2024. Among the 18 patients, total resection was achieved in 16 cases, subtotal resection in 1 case, and biopsy in 1 case. Postoperative pathological analysis revealed 9 cases of medulloblastoma, 3 cases of ependymoma, and 5 cases of astrocytoma (comprising 2 WHO grade I, 2 grade II, and 1 grade III), along with 1 case of a benign cerebellar lesion. Postoperative complications included perioperative malignant arrhythmia in 1 case, cerebellar mutism in 4 cases, and ataxia in 13 cases. During the 1-36 months follow-up period, communicating hydrocephalus was observed in 2 cases. Improvement in hydrocephalus was noted at 2 months and 6 months postoperatively following ventriculoperitoneal shunt placement. Cerebellar mutism showed significant improvement postoperatively, with an average recovery time of 21 days (range: 81 ±15 days), while ataxia improved within an average of 50 days (range: 70 ±26 days) after surgery. The latest follow-up revealed tumor recurrence in 3 patients. Neuroendoscopic surgical resection of cerebellar vermis tumors, when performed by experienced operators, can effectively achieve the necessary surgical exposure and offer an alternative to traditional microscopy.
DOI: 10.6084/m9.figshare.13678999.v3
title: WETFEET: Mangrove growth responses to warming across a latitudinal gradient.csv

description: In the southeastern US, Avicennia germinans (black mangrove) is encroaching poleward due to warming temperatures and a decrease in annual freee events. To understand how warming will continue to impact mangrove encroachment, we deployed open-top passive warming chambers at three sites along the northeast coast of Florida encompassed by the Guana Tolomato Matanzas National Estuarine Research Reserve. Mangrove height and canopy widths were measured in each of the 36 plots (3 sites x 2 treatments x 6 replicates) at the outset of the experiment in May 2018 and then again in November 2018 (6 months) and in May 2019 (1 year). Plant height was measured to the tallest branch. Canopy width was measured at the widest dimension and then again at the dimension perpendicular from the first measurement. <br>In each plot, two PVC rings were placed over existing salt marsh vegetation. In August 2018, we measured the height and number of stems (stem density) of each species present in the biomass rings. All biomass was then cut at the base for allometric measurements in the lab. This process was repeated in August 2019.<br>To assess belowground root biomass, we took 30cm soil cores from each plot using a gauge auger in May 2018 and again in May 2019. Cores were split into two sections; 0-15cm depth, and 15-30cm depth. Each section was washed free from sediment, and remaining root biomass was dried in a 60 degree C oven and weighed.
DOI: 10.6084/m9.figshare.27939504.v1
title: G-1_Sanger_sequencing

description: Sanger sequencing primers and sequences used to manually curate <i>Thermoanaerobacter kivui</i> G-1 genome.
DOI: 10.6084/m9.figshare.5353540.v1
title: genotype.RData

description: This RData contains the genotypes of 2510 dairy cows after quality control and filtering. The dataset consisted of 364 cases and 2, 146 controls genotyped for 44, 046 SNPs.
DOI: 10.6084/m9.figshare.17122277.v1
title: Rock magnetic data of core MD01-2444 at 26.74 m depth

description: These files contain the original data of rock-magnetic measurements on core MD01-2444 sample at 26.74 m depth.
DOI: 10.6084/m9.figshare.14322042.v1
title: Comparative analysis of fretting fatigue resistance between overhead conductors made of aluminum alloys 900 MCM and 823 MCM

description: ABSTRACT The electric transmission and distribution industries and utilities are looking for the most optimized components for their transmission lines. Thus, there is a need to improve the formation of the overhead conductor, which is the costliest element of electric transmission lines. Under these circumstances, conductors formed solely of aluminum wires appear to be more advantageous over aluminum conductor steel reinforced, obtaining better ampacity/weight ratios, thus lowering the transmission cost. The objective of this article was to verify the influence of the fretting fatigue phenomenon under controlled conditions, on the AA 6201 T81 and AA 1120 H19 aluminum alloy wires, which form the overhead conductors CAL 900 MCM and CAL 823 MCM, respectively. To achieve these goals, an experimental program was created capable of acquiring the data on the fatigue life of the overhead conductors and the wires separately, in order to verify the influence of fretting under a 750 N normal contact load parameter. In the results, the CAL 900 MCM achieved the lowest fatigue life, despite it made of an alloy with better mechanical properties. The same result was obtained in the fretting fatigue tests on wires, so it can be inferred that the AA 6201 T81 alloy, although it has better fatigue resistance, is more susceptible to failure in the presence of fretting when compared to AA 1120 H19 alloy.
DOI: 10.6084/m9.figshare.13688392.v1
title: Data resulting from the study for sulfate explosive growth in wet plumes emitted from typical coal-fired stationary sources

description: The origins of atmospheric sulfate production have previously been explained by focusing on air quality models and complex chemical reaction processes. Here, we first report direct observations of sulfate production in stack plumes discharged from coal-fired power plants, industrial boilers, and sintering plants equipped with wet desulfurization systems.
DOI: 10.6084/m9.figshare.14307210.v1
title: Effect of wind in the design of reinforced concrete buildings

description: ABSTRACT This paper presents the results from a parametric study carried in order to quantify how far errors in the design stage related to the consideration of the wind action may put at risk the response and safety of reinforced concrete buildings. Using an architectural model as reference and varying the number of floors of the building, the structural safety was evaluated as a function of the wind action intensity. Results showed that even for low-rise buildings, with 10 floors, ignoring the wind action can significantly jeopardize their behaviour and safety. Yet, for slenderer buildings, up to 30 floors, it can lead to catastrophic results, as the ruin of the structure by progressive collapse.
DOI: 10.6084/m9.figshare.14370854.v1
title: [Material suplementario] Maltrato infantil y violencia ejercida por la pareja: resultados de una encuesta poblacional en Perú

description: Material suplementario del estudio "Maltrato infantil y violencia ejercida por la pareja: resultados de una encuesta poblacional en Perú", que evalúa la asociación entre la ocurrencia de maltrato psicologico y fisico en la infancia, y la aceptabilidad de violencia psicológica y física ejercida por la pareja en la adultez, en una muestra representativa de mujeres peruanas.
DOI: 10.6084/m9.figshare.25514719.v1
title: ALIGNN InterMat

description: https://arxiv.org/abs/2401.02021
DOI: 10.15131/shef.data.28398266.v1
title: A snapshot of UK universities and associated academic organisations on social media.

description: The spreadsheet is a snapshot of UK universities and associated academic organisations such as publishers, funders, learned societies, media organisations, open research platforms and initiatives, research centres and other organisations.<b>The first tab contains social media information on </b>Funders and research programmesCharities,Trusts and Non GovernmentLearned SocietiesProfessional bodies, collectives and groupsResearch news and opinionOpen research, impact, data and metricsFestivals, public engagementPublishers and journalsPhD, career developmentResearch Centres and programmesConferencesThe second tab is a snapshot of UK Universities and their social media links on X, Bluesky, Threads, Mastodon, LinkedIn, Facebook and Instagram. These are categorised by colour based on the following information:Actively left XNot posted on X in 2025 (as of 6th February 2025)Still posting on XNot posted on Bluesky yet, or just a single welcome postNot posted on Threads in 2025 (as of 6th February 2025)Not posted on Mastodon in 2025A living copy of this spreadsheet can be viewed via this link.Individuals representing UK and UK-facing academic and research organisations can contribute to the spreadsheet via this Google Form
DOI: 10.15468/dl.ycwtse
title: Occurrence Download

description: A dataset containing 438 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Macrophya alboannulata Costa, 1859"
 ]
}

 The dataset includes 438 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009654-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27273957.v2
title: Raw data of metabolomics

description: <b>Serum Metabolomic Characteristics of COVID-19 Patients Co-infection with Echovirus</b>
DOI: 10.15468/dl.qtps5n
title: Occurrence Download

description: A dataset containing 572 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Papua New Guinea",
 "Geometry POLYGON((136.97561 -9.48133,145.05927 -9.48133,145.05927 -1.63464,136.97561 -1.63464,136.97561 -9.48133))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "Year 2024-2025"
 ]
}

 The dataset includes 572 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009653-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.20532144.v1
title: Supplemental data files

description: This file contains Supplemental data files associated with our manuscript entitled "Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling" submitted to AJPGI. <br> This file includes- 1. Supplemental figure and figure legends 2. Supplemental tables with a list of antibodies used. 3. Raw uncropped Western blot images. <br> <br>
DOI: 10.6084/m9.figshare.3521870.v1
title: Appendix A. Quantitative ecological characteristics of 29 Adirondack lakes used in the analysis of intraspecific divergence in the body shape of pumpkinseed sunfish.

description: Quantitative ecological characteristics of 29 Adirondack lakes used in the analysis of intraspecific divergence in the body shape of pumpkinseed sunfish.