cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24411862
title: Gene expression from 100 EAC pre-treatment biopsies

description: Despite the advent of neoadjuvant chemoradiotherapy (CRT), overall survival rates of esophageal adenocarcinoma (EAC) remain low. A readily induced mesenchymal transition of EAC cells contributes to resistance to CRT. In this study, we aimed to chart the heterogeneity in cell state transition after CRT and to identify its underpinnings. RNA-sequencing was performed on 100 pre-treatment biopsies.
DOI: 10.6084/m9.figshare.24411862.v1
title: Gene expression from 100 EAC pre-treatment biopsies

description: Despite the advent of neoadjuvant chemoradiotherapy (CRT), overall survival rates of esophageal adenocarcinoma (EAC) remain low. A readily induced mesenchymal transition of EAC cells contributes to resistance to CRT. In this study, we aimed to chart the heterogeneity in cell state transition after CRT and to identify its underpinnings. RNA-sequencing was performed on 100 pre-treatment biopsies.
DOI: 10.6084/m9.figshare.9980945.v1
title: The clinical impact of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and neuropsychological intervention in routine ALS care

description: <i>Objectives.</i> The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) is a brief multi-domain assessment designed for people with Amyotrophic Lateral Sclerosis (ALS). This study evaluated the clinical impact of using the ECAS on ALS patients, carers and healthcare professionals. A secondary aim was to evaluate the clinical impact of neuropsychological intervention. <i>Methods.</i> A survey of current screening practices in ALS services across the UK was undertaken. In addition comparative case studies, in seven ALS care contexts, was qualitatively explored through interviews with patients, carers and healthcare professionals. <i>Results.</i> 22/34 health care services responded to the survey. 95% screen patients for cognitive and behavioral changes and all used the ECAS. Thematic analysis indicated that the ECAS: raises awareness about cognitive and behavioral change between patients, carers and healthcare professionals; validates and/or reassures; identifies changes, aids understanding of the patients’ presentation and informs clinical decision-making. The latter includes suitability of interventions, adaptations by the multidisciplinary team, discussions about end-of-life care, referral on to other services, and identifying carers’ support needs. A number of indirect economic benefits were described. Clinical neuropsychological intervention was reported to help the multidisciplinary team manage the care particularly of complex cases, the effects on daily life, and stress of patients, carers and families. <i>Conclusions.</i> The ECAS has been widely implemented across ALS health care teams in the UK. Screening for cognitive/behavioral deficits and neuropsychological intervention has a positive impact on patients, carers and healthcare professionals and improves the quality of routine clinical care.
DOI: 10.6084/m9.figshare.10075394.v2
title: HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation

description: <i>Aim</i>: The demonstration that chaperone-mediated autophagy (CMA) contributes to the degradation of TDP-43, the main constituent of cytoplasmic inclusions typically found in motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS), has pointed out a possible involvement of CMA in aggregate formation. To explore this possibility, in this study, we verified the presence of a possible systemic CMA alteration in sALS patients and its effect on TDP-43 expression. <i>Materials and methods</i>: Gene and protein expression of the cytosolic chaperone HSC70 and the lysosome receptor LAMP2A, the two pivotal mediators of CMA, was assessed in peripheral blood mononuclear cells (PBMCs) derived from 30 sALS patients and 30 healthy controls. The expression of TDP-43 and co-chaperones BAG1 and BAG3 was also analyzed. <i>Results</i>: We found reduced HSC70 expression in patient cells, with no change in LAMP2A, and increased insoluble TDP-43 protein levels, with an aberrant intracellular localization. We also observed an unbalanced expression of co-chaperones BAG1 and BAG3. HSC70 down-regulation was confirmed in immortalized lymphoblastoid cell lines derived from sporadic and TARDBP mutant ALS patients. Lastly, we demonstrated that HSC70 silencing directly increases TDP-43 protein levels in human neuroblastoma cells. <i>Discussion</i>: Our results do not support the existence of a systemic CMA alteration in sALS patients but indicate a direct involvement of HSC70 alterations in ALS pathogenesis.
DOI: 10.6084/m9.figshare.9980945
title: The clinical impact of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and neuropsychological intervention in routine ALS care

description: <i>Objectives.</i> The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) is a brief multi-domain assessment designed for people with Amyotrophic Lateral Sclerosis (ALS). This study evaluated the clinical impact of using the ECAS on ALS patients, carers and healthcare professionals. A secondary aim was to evaluate the clinical impact of neuropsychological intervention. <i>Methods.</i> A survey of current screening practices in ALS services across the UK was undertaken. In addition comparative case studies, in seven ALS care contexts, was qualitatively explored through interviews with patients, carers and healthcare professionals. <i>Results.</i> 22/34 health care services responded to the survey. 95% screen patients for cognitive and behavioral changes and all used the ECAS. Thematic analysis indicated that the ECAS: raises awareness about cognitive and behavioral change between patients, carers and healthcare professionals; validates and/or reassures; identifies changes, aids understanding of the patients’ presentation and informs clinical decision-making. The latter includes suitability of interventions, adaptations by the multidisciplinary team, discussions about end-of-life care, referral on to other services, and identifying carers’ support needs. A number of indirect economic benefits were described. Clinical neuropsychological intervention was reported to help the multidisciplinary team manage the care particularly of complex cases, the effects on daily life, and stress of patients, carers and families. <i>Conclusions.</i> The ECAS has been widely implemented across ALS health care teams in the UK. Screening for cognitive/behavioral deficits and neuropsychological intervention has a positive impact on patients, carers and healthcare professionals and improves the quality of routine clinical care.
DOI: 10.6084/m9.figshare.10075394
title: HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation

description: <i>Aim</i>: The demonstration that chaperone-mediated autophagy (CMA) contributes to the degradation of TDP-43, the main constituent of cytoplasmic inclusions typically found in motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS), has pointed out a possible involvement of CMA in aggregate formation. To explore this possibility, in this study, we verified the presence of a possible systemic CMA alteration in sALS patients and its effect on TDP-43 expression. <i>Materials and methods</i>: Gene and protein expression of the cytosolic chaperone HSC70 and the lysosome receptor LAMP2A, the two pivotal mediators of CMA, was assessed in peripheral blood mononuclear cells (PBMCs) derived from 30 sALS patients and 30 healthy controls. The expression of TDP-43 and co-chaperones BAG1 and BAG3 was also analyzed. <i>Results</i>: We found reduced HSC70 expression in patient cells, with no change in LAMP2A, and increased insoluble TDP-43 protein levels, with an aberrant intracellular localization. We also observed an unbalanced expression of co-chaperones BAG1 and BAG3. HSC70 down-regulation was confirmed in immortalized lymphoblastoid cell lines derived from sporadic and TARDBP mutant ALS patients. Lastly, we demonstrated that HSC70 silencing directly increases TDP-43 protein levels in human neuroblastoma cells. <i>Discussion</i>: Our results do not support the existence of a systemic CMA alteration in sALS patients but indicate a direct involvement of HSC70 alterations in ALS pathogenesis.
DOI: 10.6084/m9.figshare.10075394.v1
title: HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation

description: <i>Aim</i>: The demonstration that chaperone-mediated autophagy (CMA) contributes to the degradation of TDP-43, the main constituent of cytoplasmic inclusions typically found in motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS), has pointed out a possible involvement of CMA in aggregate formation. To explore this possibility, in this study, we verified the presence of a possible systemic CMA alteration in sALS patients and its effect on TDP-43 expression. <i>Materials and methods</i>: Gene and protein expression of the cytosolic chaperone HSC70 and the lysosome receptor LAMP2A, the two pivotal mediators of CMA, was assessed in peripheral blood mononuclear cells (PBMCs) derived from 30 sALS patients and 30 healthy controls. The expression of TDP-43 and co-chaperones BAG1 and BAG3 was also analyzed. <i>Results</i>: We found reduced HSC70 expression in patient cells, with no change in LAMP2A, and increased insoluble TDP-43 protein levels, with an aberrant intracellular localization. We also observed an unbalanced expression of co-chaperones BAG1 and BAG3. HSC70 down-regulation was confirmed in immortalized lymphoblastoid cell lines derived from sporadic and TARDBP mutant ALS patients. Lastly, we demonstrated that HSC70 silencing directly increases TDP-43 protein levels in human neuroblastoma cells. <i>Discussion</i>: Our results do not support the existence of a systemic CMA alteration in sALS patients but indicate a direct involvement of HSC70 alterations in ALS pathogenesis.
DOI: 10.5281/zenodo.8301762
title: Transliterated Fragments of the Electronic Babylonian Literature Project (eBL)

description: <pre>Data from Paper "Transliterated Fragments of the Electronic Babylonian Literature Project (eBL, https://www.ebl.lmu.de/)</pre> Use together with code https://github.com/ElectronicBabylonianLiterature/tansliterated-fragments
DOI: 10.5281/zenodo.10018951
title: Transliterated Fragments of the Electronic Babylonian Literature Project (eBL)

description: Data from Paper "Transliterated Fragments of the Electronic Babylonian Literature Project (eBL, https://www.ebl.lmu.de/)


Use together with code https://github.com/ElectronicBabylonianLiterature/tansliterated-fragments
DOI: 10.5281/zenodo.8301761
title: Transliterated Fragments of the Electronic Babylonian Literature Project (eBL)

description: Data from Paper "Transliterated Fragments of the Electronic Babylonian Literature Project (eBL, https://www.ebl.lmu.de/)


Use together with code https://github.com/ElectronicBabylonianLiterature/tansliterated-fragments
DOI: 10.5517/ccdc.csd.cc2fl67h
title: CCDC 2251816: Experimental Crystal Structure Determination

description: Related Article: Liam K. Burt, Anthony F. Hill|2023|Dalton Trans.|52|13906|doi:10.1039/D3DT02649C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fl6bl
title: CCDC 2251819: Experimental Crystal Structure Determination

description: Related Article: Liam K. Burt, Anthony F. Hill|2023|Dalton Trans.|52|13906|doi:10.1039/D3DT02649C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gvgmf
title: CCDC 2289555: Experimental Crystal Structure Determination

description: Related Article: Thien H. Nguyen, Christophe Pauly, Greggory T. Kent, Guang Wu, Trevor W. Hayton|2023|Dalton Trans.|52|13868|doi:10.1039/D3DT02741D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gvgng
title: CCDC 2289556: Experimental Crystal Structure Determination

description: Related Article: Thien H. Nguyen, Christophe Pauly, Greggory T. Kent, Guang Wu, Trevor W. Hayton|2023|Dalton Trans.|52|13868|doi:10.1039/D3DT02741D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.7734163
title: How to Compute Atomistic Insight in DFT clusters: the REG-IQA Approach

description: Dataset for the paper "How to Compute Atomistic Insight in DFT clusters: the REG-IQA Approach" published to Journal of Chemical Information and Modelling.
The Dataset contains all the AIMAll calculations for each step of the intrinsic reaction coordinate of the HIV Protease hydrolysis described in the main manuscript and .xlsx files for all the REG-IQA results of the analyses pursued.
DOI: 10.5281/zenodo.7734164
title: How to Compute Atomistic Insight in DFT clusters: the REG-IQA Approach

description: Dataset for the paper "How to Compute Atomistic Insight in DFT clusters: the REG-IQA Approach" submitted to<em> Journal of Chemical Information and Modelling</em>. The Dataset contains all the AIMAll calculations for each step of the intrinsic reaction coordinate of the HIV Protease hydrolysis described in the main manuscript and .xlsx files for all the REG-IQA results of the analyses pursued.
DOI: 10.5281/zenodo.7925107
title: How to Compute Atomistic Insight in DFT clusters: the REG-IQA Approach

description: Dataset for the paper "How to Compute Atomistic Insight in DFT clusters: the REG-IQA Approach" published to Journal of Chemical Information and Modelling.
The Dataset contains all the AIMAll calculations for each step of the intrinsic reaction coordinate of the HIV Protease hydrolysis described in the main manuscript and .xlsx files for all the REG-IQA results of the analyses pursued.
DOI: 10.6084/m9.figshare.24331279
title: GWN Sample Data (CSP, SNA, AP)

description: Carotid sinus pressure (CSP), sympathetic nerve activity (SNA), and arterial pressure (AP) data obtained in anesthetized rats. The data were re-sampled at 10 Hz. The CSP was perturbed with Gaussian white noise signals with a mean of 120 mmHg and standard deviations of 10, 20, and 30 mmHg for 15 min each.
DOI: 10.6084/m9.figshare.24331279.v1
title: GWN Sample Data (CSP, SNA, AP)

description: Carotid sinus pressure (CSP), sympathetic nerve activity (SNA), and arterial pressure (AP) data obtained in anesthetized rats. The data were re-sampled at 10 Hz. The CSP was perturbed with Gaussian white noise signals with a mean of 120 mmHg and standard deviations of 10, 20, and 30 mmHg for 15 min each.
DOI: 10.6084/m9.figshare.24411922
title: Input data required to reproduce analysis for Score2

description: Pacini et al identify selective gene dependencies from CRISPR screens in 930 cell lines. Using clinically curated multi-omics data and protein-protein interactions networks, they curate 370 candidate targets and estimate their prevalence in patient tumour cohorts. This enhances understanding of gene depenencies and comprehensively maps targetable cancer dependencies.
DOI: 10.6084/m9.figshare.24411943
title: Data set for <i>TYMS </i>gene polymorphism

description: Data set
DOI: 10.6084/m9.figshare.24411943.v1
title: Data set for <i>TYMS </i>gene polymorphism

description: Data set
DOI: 10.7916/bxa4-bv46
title:  GRID3 SLE Settlement Names, Version 1.0
DOI: 10.18167/dvn1/igmhs7
title: WAT4CAM - Households socio-economic survey data in Battambang and Preah Vihear province (Cambodia) 2020

description: This dataset contains thirteen csv files including households’ answers to the WAT4CAM survey (2019-2020) in two Cambodian provinces and two text file presenting a more detailed description and the questionnaire content. Ce jeu de données contient treize fichiers csv comprenant les réponses des ménages à l'enquête WAT4CAM (2019-2020) dans deux provinces cambodgiennes et deux fichiers texte présentant une description plus détaillée et le contenu du questionnaire.
DOI: 10.34740/kaggle/dsv/6748985
title: COVID Vaccination in World (updated daily)
DOI: 10.5517/ccdc.csd.cc28kxf6
title: CCDC 2102588: Experimental Crystal Structure Determination

description: Related Article: Pooja Rani, Ahmad Husain, K. K. Bhasin, Girijesh Kumar|2022|Chem.Asian J.|17|e202101204|doi:10.1002/asia.202101204
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28kxlc
title: CCDC 2102593: Experimental Crystal Structure Determination

description: Related Article: Pooja Rani, Ahmad Husain, K. K. Bhasin, Girijesh Kumar|2022|Chem.Asian J.|17|e202101204|doi:10.1002/asia.202101204
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d94c7
title: CCDC 2213318: Experimental Crystal Structure Determination

description: Related Article: M. Nishimoto, Y. Uetake, Y. Yakiyama, H. Sakurai|2023|Chem.Asian J.|18|e202201103|doi:10.1002/asia.202201103
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dzb4w
title: CCDC 2233678: Experimental Crystal Structure Determination

description: Related Article: Ramalingam  Natarajan, SAndipan Ghorai, Suman Maji, Shovan Kumar Sen|2023|Chem.Asian J.|18|e202201312|doi:10.1002/asia.202201312
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.22128842
title: IRIS

description: Data associated with manuscript published in Communications Biology
DOI: 10.14768/52460ee0-30d3-4c89-8a01-888966d68087
title: IASI monthly O3 partial columns over European, Eastern US and Western US Mountains between 2008 and 2020

description: Mean monthly partial O3 columns between 2008 and 2020 retrieved from IASI over European (5-20°E,40-50°N), Eastern US (70-85°W,35-50°N) and Western US(100-125°W,30-50°N) Mountains. The data correspond to the lowermost troposphere (surface-3km), the lower free troposphere (3-6km), the upper free troposphere (6-9km), and the upper troposphere lowermost stratosphere (9-12km). These data have been used for ozone analysis (Putero et al., 2023) in the framework of the tropospheric ozone assessment report – phase 2 international initiative.
DOI: 10.6084/m9.figshare.20802700
title: HapMap3-1KG: 1000 Genomes processed genotypes in PLINK (.bed/bim/fam) format

description: Genotypes from the 1000 Genomes reference<sup> </sup>[1] (v5) were intersected with HapMap3 [2] variants based on rsids, and filtered to contain variants with an allele frequency of at least 1% in any of the "superpopulations" (AMR, AFR, EAS, EUR, SAS) defined by 1000 Genomes.<br><br>This data serves as a population reference for the comparison of polygenic scoring methods, as described in Monti et al. [3]. A more detailed description of how the genotypes were processed is provided in that manuscript.<br><br>When using this data, all three sources should be acknowledged:[1] Auton, A. <i>et al.</i> A global reference for human genetic variation. <i>Nature</i> <b>526</b>, 68–74 (2015)<br>[2] Altshuler, D. M. <i>et al.</i> Integrating common and rare genetic variation in diverse human populations. <i>Nature</i> <b>467</b>, 52–58 (2010)<br>[3]<br><br>The funding statement here refers only to the processing of the data, not data generation. Consider the sources above for full funding statements.<br><br>
DOI: 10.6084/m9.figshare.24411967
title: Scoping review of health benefits of culinary doses of herbs and spices raw data.xlsx

description: Data for a scoping review looking at the metabolic health benefits of culinary doses (those that might reasonably be achieved in food) of herbs and spices.
DOI: 10.6084/m9.figshare.24401146
title: R script and data from: Fallen trees as “natural bridges” for the movement of mammals crossing rivers

description: Script and datasets to reproduce all analyses from: Fallen trees as “natural bridges” for the movement of mammals crossing rivers
DOI: 10.6084/m9.figshare.24401146.v1
title: R script and data from: Fallen trees as “natural bridges” for the movement of mammals crossing rivers

description: Script and datasets to reproduce all analyses from: Fallen trees as “natural bridges” for the movement of mammals crossing rivers
DOI: 10.48420/22148963
title: Research data for "Accurate and efficient spin-phonon coupling and spin dynamics calculations for molecular solids"

description: This dataset contains the optimised crystalline geometry of [Dy(bbpen)Br], the phonon spectra obtained using a 2x2x1 supercell, the third-order force constants, the ab-initio calculated phonon lifetimes, and the magnetic relaxation rate calculations. These data allow us to understand the influence of phonon-phonon scattering on phonon linewidth, and how this influences magnetic relaxation.
DOI: 10.6084/m9.figshare.24408892.v1
title: Main results NSS

description: NSS - Number of Successful sequence
DOI: 10.18167/dvn1/bqef0o
title: NIRS Calibration Database on raw mashed Sweetpotato for Sensory Descriptors, Texture, DM, OCT Water absorption at CIP Uganda

description: The spectra were collected from 3 raw mashed roots. To scan raw mashed roots, atleast 3 raw roots were mashed together into a fine mash . After mashing, 3 subsamples were collected into a cuvette and scanned, producing three spectra per genotype. Sensory data was collected by 12 trained panellists, who consumed small cubes of each cooked sweetpotato genotype and rated the overall liking of the samples on a 10-point hedonic scale ranging from 1 (dislike extremely) to 10 (like extremely), for each sensory trait per genotypes.