cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31429172.v1
title: Genomic and structural insights into TATA-Binding protein from cestodes

description: The TATA-binding protein (TBP) is an essential component of the eukaryotic transcriptional machinery, yet little is known about the structure, evolution, and functional divergence of TBP paralogs in parasitic flatworms. Here, we performed a comprehensive comparative analysis of TBP1 and TBP2 across cestode species of medical and veterinary relevance. Using genomic annotation, multiple sequence alignment, homology modeling, phylogenetics, electrostatic potential mapping, and protein – DNA docking complemented with molecular dynamics (MD) simulations, we reveal that both paralogs maintain a highly conserved genomic organization and the canonical TBP α/β saddle architecture. TBP1 exhibits moderate variability in sequence and electrostatic in peripheral regions, whereas TBP2 is more conserved, suggesting distinct evolutionary constraints. Despite paralog divergence, all cestode TBPs retain the key aromatic and basic residues required for minor-groove recognition of the TATA box and interaction with general transcription factors. Docking and MD simulations confirm a conserved pattern of TATA-binding across species, with TBP2 displaying exceptionally uniform interaction networks. Together, these findings provide genomic and structural data for TBPs in cestodes, suggesting the existence of paralog-specific regulatory roles and offering new insights into transcriptional control in parasitic flatworms.
DOI: 10.25549/maw-ouc11399dlyl
title: Nayarit group : pole ceremony [3D]

description: Nine individuals sit facing inward towards a central pole. Eight of the individuals appear to be adults or possibly couples. The ninth figure appears to be a juvenile. The grouping suggests a ceremonial procedure.
DOI: 10.25549/maw-ouc113888693
title: Ceramic earspools : 2

description: There are twenty-eight ceramic ear spools. Fourteen are black ware, six orange ware, five tan ware, one incised, one polychrome, one cone-shaped. Riker Mount has six orange ware. Riker Box has twenty-two ear spools, four different styles.17 napkin ring, 6 Horer color, 2 cone shape, 1 tube shape. 1 solid, 3 pierced, 1 incised, 1 painted polychrome.
DOI: 10.6084/m9.figshare.31429175
title: Supplementary Material for: Stevens-Johnson Syndrome Following A single Ampicillin Dose in an Elderly Patient: A Case Report

description: Stevens-Johnson Syndrome (SJS) is a rare but life-threatening mucocutaneous disorder, most commonly triggered by medications. This case report presents a 75-year-old Armenian female who developed severe SJS following a single dose of ampicillin. She initially presented with fever, generalized weakness, and a rapidly progressing bullous rash affecting her face, neck, upper limbs, and chest. Her medical history included untreated rheumatoid arthritis and chronic bronchitis, for which she had been self-medicating with corticosteroids and other medications. Despite early initiation of high-dose corticosteroids and supportive therapy, her condition deteriorated, leading to septicemia and respiratory failure, necessitating admission to the Infectious Diseases Department. Multidisciplinary management, including immunosuppressive therapy with cyclosporine and targeted antimicrobial treatment, resulted in clinical stabilization and eventual recovery.
DOI: 10.6084/m9.figshare.31429175.v1
title: Supplementary Material for: Stevens-Johnson Syndrome Following A single Ampicillin Dose in an Elderly Patient: A Case Report

description: Stevens-Johnson Syndrome (SJS) is a rare but life-threatening mucocutaneous disorder, most commonly triggered by medications. This case report presents a 75-year-old Armenian female who developed severe SJS following a single dose of ampicillin. She initially presented with fever, generalized weakness, and a rapidly progressing bullous rash affecting her face, neck, upper limbs, and chest. Her medical history included untreated rheumatoid arthritis and chronic bronchitis, for which she had been self-medicating with corticosteroids and other medications. Despite early initiation of high-dose corticosteroids and supportive therapy, her condition deteriorated, leading to septicemia and respiratory failure, necessitating admission to the Infectious Diseases Department. Multidisciplinary management, including immunosuppressive therapy with cyclosporine and targeted antimicrobial treatment, resulted in clinical stabilization and eventual recovery.
DOI: 10.25549/maw-ouc113889072
title: Ceramic earspools : 2

description: There are twenty-eight ceramic ear spools. Fourteen are black ware, six orange ware, five tan ware, one incised, one polychrome, one cone-shaped. Riker Mount has six orange ware. Riker Box has twenty-two ear spools, four different styles.17 napkin ring, 6 Horer color, 2 cone shape, 1 tube shape. 1 solid, 3 pierced, 1 incised, 1 painted polychrome.
DOI: 10.6084/m9.figshare.31429178
title: Supplementary Material for: Successful Treatment of Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis with Pegcetacoplan: A Case Report

description: Immune complex–mediated membranoproliferative glomerulonephritis (IC-MPGN) lacks proven targeted therapy and is often refractory to non-specific immunosuppression. Dysregulation of the alternative complement pathway provides a mechanistic rationale for proximal C3 inhibition. A 19-year-old man presented with nephrotic-range proteinuria (24-hour protein 7,988 mg/day; urine protein–creatinine ratio [UPCR] 2,502 mg/g), haematuria, hypoalbuminaemia (20 g/L), and depressed complement (C3 0.06–0.14 g/L with normal C4). Kidney biopsy demonstrated IC-MPGN with granular IgA/IgG/C3 along capillary loops and electron-dense deposits in subendothelial, intramembranous, and subepithelial locations. Despite treatment with corticosteroids and tacrolimus, disease activity persisted, prompting initiation of pegcetacoplan 1,080 mg subcutaneously twice weekly. By August 2025, UPCR decreased to 751 mg/g (−70% from baseline), and 24-hour urinary protein excretion declined to 1,386 mg/day (−83%). Serum albumin increased from 20 to 36 g/L, while serum creatinine remained stable (92 µmol/L). Complement levels normalised, with C3 rising from 0.06 g/L to 1.27 g/L and C4 improving to 0.18 g/L, permitting discontinuation of antihypertensive and immunosuppressive medications. No adverse events were observed. Pegcetacoplan achieved rapid biochemical and clinical remission in refractory IC-MPGN, enabling cessation of non-specific immunosuppression and supporting C3-targeted therapy for complement-dysregulated disease. Longer follow-up with histologic correlation and biomarker-guided selection is needed to define durability and responders.
DOI: 10.6084/m9.figshare.31429178.v1
title: Supplementary Material for: Successful Treatment of Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis with Pegcetacoplan: A Case Report

description: Immune complex–mediated membranoproliferative glomerulonephritis (IC-MPGN) lacks proven targeted therapy and is often refractory to non-specific immunosuppression. Dysregulation of the alternative complement pathway provides a mechanistic rationale for proximal C3 inhibition. A 19-year-old man presented with nephrotic-range proteinuria (24-hour protein 7,988 mg/day; urine protein–creatinine ratio [UPCR] 2,502 mg/g), haematuria, hypoalbuminaemia (20 g/L), and depressed complement (C3 0.06–0.14 g/L with normal C4). Kidney biopsy demonstrated IC-MPGN with granular IgA/IgG/C3 along capillary loops and electron-dense deposits in subendothelial, intramembranous, and subepithelial locations. Despite treatment with corticosteroids and tacrolimus, disease activity persisted, prompting initiation of pegcetacoplan 1,080 mg subcutaneously twice weekly. By August 2025, UPCR decreased to 751 mg/g (−70% from baseline), and 24-hour urinary protein excretion declined to 1,386 mg/day (−83%). Serum albumin increased from 20 to 36 g/L, while serum creatinine remained stable (92 µmol/L). Complement levels normalised, with C3 rising from 0.06 g/L to 1.27 g/L and C4 improving to 0.18 g/L, permitting discontinuation of antihypertensive and immunosuppressive medications. No adverse events were observed. Pegcetacoplan achieved rapid biochemical and clinical remission in refractory IC-MPGN, enabling cessation of non-specific immunosuppression and supporting C3-targeted therapy for complement-dysregulated disease. Longer follow-up with histologic correlation and biomarker-guided selection is needed to define durability and responders.
DOI: 10.25549/maw-ouc113888708
title: Labret : ear ornament

description: To make this object require time, skill and craftsmanship. The black obsidian was core flaked for the basic shape and size. Small pieces of obsidian would be pushed off by pressure flaking. The shape would be refined by wearing away the surface with abrasive rocks and sand.
DOI: 10.25549/maw-ouc113889070
title: West Mexican stamp seals : two

description: Both of these stamp seals are perforated for suspension. They depict abstract faces wearing a triple tipped headdress, large round eyes with three vertical linear elements below them. The images suggest the Rain God, Tlaloc.
DOI: 10.6084/m9.figshare.31429181
title: Supplementary Material for: Monocentric, vehicle-controlled, double-blind study to assess the short- and long-term effects of a Ceramide NP C15-containing emollient on the skin microbiome and the skin barrier function in sensitive skin

description: Introduction:

Sensitive skin is a common skin condition that impairs quality of life and is characterised by unpleasant sensations to normally non-irritating stimuli. Restoration of skin barrier integrity can relieve symptoms, and accumulating evidence indicates a contributory role of the skin microbiome not only in barrier function but also as a potential modulator in sensitive skin. Ceramide-containing emollients improve barrier function and may modulate microbial communities via restoration of stratum corneum lipids, hydration, and immune regulation. 

Methods:

In this randomized, double-blind, vehicle-controlled trial, an emollient containing Ceramide NP C15 was evaluated for its effects on sensitive skin symptoms and skin barrier function. Fifty participants applied the study products in a split-body design for six weeks. Primary assessments included skin physiology and symptom burden. Furthermore, skin microbiota changes were explored using flow cytometry (FC)-based bacterial profiling and 16s rRNA gene sequencing.

Results:

Both the Ceramide NP C15 formulation and the vehicle were associated with improvements in subjective symptoms. In participants with impaired skin barrier, treatment with the ceramide formulation was associated with a significant reduction in transepidermal water loss. FC- and 16S-based analyses indicated modest, treatment-associated changes in skin microbiota composition including an early and sustained increase in microbial evenness and a significant enrichment of Bifidobacterium.

Conclusion:

In this exploratory, randomized controlled study, a Ceramide NP C15-containing emollient was associated with improvements in skin barrier function. Exploratory microbiome analyses suggested treatment-associated changes in microbial community characteristics, which should prompt further investigations in their clinical relevance for sensitive skin.
DOI: 10.6084/m9.figshare.31429181.v1
title: Supplementary Material for: Monocentric, vehicle-controlled, double-blind study to assess the short- and long-term effects of a Ceramide NP C15-containing emollient on the skin microbiome and the skin barrier function in sensitive skin

description: Introduction:

Sensitive skin is a common skin condition that impairs quality of life and is characterised by unpleasant sensations to normally non-irritating stimuli. Restoration of skin barrier integrity can relieve symptoms, and accumulating evidence indicates a contributory role of the skin microbiome not only in barrier function but also as a potential modulator in sensitive skin. Ceramide-containing emollients improve barrier function and may modulate microbial communities via restoration of stratum corneum lipids, hydration, and immune regulation. 

Methods:

In this randomized, double-blind, vehicle-controlled trial, an emollient containing Ceramide NP C15 was evaluated for its effects on sensitive skin symptoms and skin barrier function. Fifty participants applied the study products in a split-body design for six weeks. Primary assessments included skin physiology and symptom burden. Furthermore, skin microbiota changes were explored using flow cytometry (FC)-based bacterial profiling and 16s rRNA gene sequencing.

Results:

Both the Ceramide NP C15 formulation and the vehicle were associated with improvements in subjective symptoms. In participants with impaired skin barrier, treatment with the ceramide formulation was associated with a significant reduction in transepidermal water loss. FC- and 16S-based analyses indicated modest, treatment-associated changes in skin microbiota composition including an early and sustained increase in microbial evenness and a significant enrichment of Bifidobacterium.

Conclusion:

In this exploratory, randomized controlled study, a Ceramide NP C15-containing emollient was associated with improvements in skin barrier function. Exploratory microbiome analyses suggested treatment-associated changes in microbial community characteristics, which should prompt further investigations in their clinical relevance for sensitive skin.
DOI: 10.25549/maw-ouc113889075
title: West Mexican stamp seals : two

description: Both of these stamp seals are perforated for suspension. They depict abstract faces wearing a triple tipped headdress, large round eyes with three vertical linear elements below them. The images suggest the Rain God, Tlaloc.
DOI: 10.6084/m9.figshare.31429184
title: Supplementary Material for: Myelodysplastic Neoplasm with Increased Blasts-1 Presenting with Concurrent Diagnostic and Prognostically Relevant Morphologic Features: A Case Report

description: Introduction:Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and morphologic dysplasia, with a variable risk of progression to acute myeloid leukemia. Despite advances in molecular diagnostics, bone marrow morphology remains a cornerstone of diagnosis and risk stratification.
Case Presentation:We report the case of a 72-year-old woman who presented with progressive fatigue and pancytopenia. Bone marrow examination revealed prominent dyserythropoiesis, dysgranulopoiesis, numerous micromegakaryocytes with unilobed nuclei, scattered atypical spindle-shaped mast cells, and 5–7% blasts. These findings fulfilled the diagnostic criteria for myelodysplastic neoplasm with increased blasts-1 (MDS-IB1) according to the WHO 2022 classification. Conventional cytogenetics demonstrated a normal female karyotype.
Conclusion:This case illustrates the diagnostic and prognostically relevant value of concurrent morphologic abnormalities across multiple hematopoietic lineages in MDS. It underscores the enduring importance of meticulous bone marrow morphologic assessment, particularly when comprehensive molecular data are not immediately available.
DOI: 10.6084/m9.figshare.31429184.v1
title: Supplementary Material for: Myelodysplastic Neoplasm with Increased Blasts-1 Presenting with Concurrent Diagnostic and Prognostically Relevant Morphologic Features: A Case Report

description: Introduction:Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and morphologic dysplasia, with a variable risk of progression to acute myeloid leukemia. Despite advances in molecular diagnostics, bone marrow morphology remains a cornerstone of diagnosis and risk stratification.
Case Presentation:We report the case of a 72-year-old woman who presented with progressive fatigue and pancytopenia. Bone marrow examination revealed prominent dyserythropoiesis, dysgranulopoiesis, numerous micromegakaryocytes with unilobed nuclei, scattered atypical spindle-shaped mast cells, and 5–7% blasts. These findings fulfilled the diagnostic criteria for myelodysplastic neoplasm with increased blasts-1 (MDS-IB1) according to the WHO 2022 classification. Conventional cytogenetics demonstrated a normal female karyotype.
Conclusion:This case illustrates the diagnostic and prognostically relevant value of concurrent morphologic abnormalities across multiple hematopoietic lineages in MDS. It underscores the enduring importance of meticulous bone marrow morphologic assessment, particularly when comprehensive molecular data are not immediately available.
DOI: 10.25549/maw-ouc113985475
title: Spouted bottle with convex sides

description: Tlatilco was located along a small stream near the ancient great lakes. The area was rich in flora and fauna, which allowed them to make lavish gifts to be buried with their dead
DOI: 10.25549/maw-ouc113985497
title: Spouted bottle with convex sides

description: Tlatilco was located along a small stream near the ancient great lakes. The area was rich in flora and fauna, which allowed them to make lavish gifts to be buried with their dead
DOI: 10.6084/m9.figshare.31429187
title: Supplementary Material for: Respiratory syncytial virus nonstructural protein 1 inhibits production of cytokines and chemokines by differentiated primary nasal epithelial cells cultured at air-liquid interface

description: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and older adults. Currently approved vaccines target only the viral fusion protein, but live-attenuated vaccines - e.g. through inactivation of nonstructural protein 1 (NS1) - likely induce a broader immune response. NS1 inhibits the immune response by repressing interferon production, but this has mostly been shown in immortalized cell lines, which do not necessarily represent the in vivo situation. Here, we assessed the effect of NS1 mutations on replication and host responses in physiologically relevant differentiated primary human nasal epithelial cells (HNEC) cultured at air-liquid interface (ALI). Using yeast-based reverse genetics, NS1-inactivating mutations were introduced. In differentiated HNECs, NS1 mutants showed delayed replication compared to wild-type virus. Bulk RNA sequencing early after infection revealed stronger antiviral signatures in HNEC infected with NS1 mutants compared to wild-type, characterized by upregulation of interferons and chemokines. Cytokine analysis confirmed these results. Finally, an indirect immune cell migration assay revealed that both WT and NS1-mutant viruses induce migration of mainly neutrophils. In conclusion, this study shows that RSV NS1 supports viral replication not only via inhibition of the production of interferons, but also by reducing early chemokine production and secretion by epithelial cells. Together, our data highlight the suitability of the ALI transwell model for preclinical assessment of live-attenuated vaccine candidates.
DOI: 10.6084/m9.figshare.31429187.v1
title: Supplementary Material for: Respiratory syncytial virus nonstructural protein 1 inhibits production of cytokines and chemokines by differentiated primary nasal epithelial cells cultured at air-liquid interface

description: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and older adults. Currently approved vaccines target only the viral fusion protein, but live-attenuated vaccines - e.g. through inactivation of nonstructural protein 1 (NS1) - likely induce a broader immune response. NS1 inhibits the immune response by repressing interferon production, but this has mostly been shown in immortalized cell lines, which do not necessarily represent the in vivo situation. Here, we assessed the effect of NS1 mutations on replication and host responses in physiologically relevant differentiated primary human nasal epithelial cells (HNEC) cultured at air-liquid interface (ALI). Using yeast-based reverse genetics, NS1-inactivating mutations were introduced. In differentiated HNECs, NS1 mutants showed delayed replication compared to wild-type virus. Bulk RNA sequencing early after infection revealed stronger antiviral signatures in HNEC infected with NS1 mutants compared to wild-type, characterized by upregulation of interferons and chemokines. Cytokine analysis confirmed these results. Finally, an indirect immune cell migration assay revealed that both WT and NS1-mutant viruses induce migration of mainly neutrophils. In conclusion, this study shows that RSV NS1 supports viral replication not only via inhibition of the production of interferons, but also by reducing early chemokine production and secretion by epithelial cells. Together, our data highlight the suitability of the ALI transwell model for preclinical assessment of live-attenuated vaccine candidates.
DOI: 10.25549/maw-ouc113985470
title: Seated figure : Morelos baby

description: Infantile figures have been found throughout Mesoamerica. The Morelos figure exhibits great care in the sculpting of the hair, the face, especially the mouth, feet and toes. The belly, arms and legs indicate abundance, but the figure has not been fully developed.
DOI: 10.15468/dl.rbj8u9
title: Occurrence Download

description: A dataset containing 1024 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Xenops minutus",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2026",
 "Country is Colombia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1024 records from 121 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001332-260226173443078/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/maw-ouc113985462
title: Tlatilco acrobat

description: An unusual figure portraying an acrobat. The maker didn't quite understand bending human anatomy and 3-D sculpture. They created a three-dimensional male elite figure with a flat two-dimensional perspective
DOI: 10.25549/maw-ouc113985509
title: Standing bearded male

description: During the Preclassic period, hand-modeled human figures were produced in abundance. The vast majority are female fertility figures, but there are the occasional males, shamans, and ballplayers.
DOI: 10.25549/maw-ouc113888873
title: Obsidian jewelry : earrings

description: Once a thin obsidian blade has been knocked off the core, it can be shaped by pressing off tiny pieces of the volcanic stone. The edges can be dulled by rubbing them with different stones. Holes are drilled for suspension. This pair of earrings was crafted this way.
DOI: 10.25549/maw-ouc113889083
title: Colima anthropomorphic, zoomorphic figure

description: The eyes, ears, mouth, and spine were inlaid in this figurative deep blue-green stone. The stone's image is obviously male, but less apparent are the secondary front and rear faces. Lay the stone stomach down, it transforms into a resting frog, the symbol of fertility. The stone transforms from a man to a frog and maybe a dog.
DOI: 10.25549/maw-ouc113889098
title: Macehead : transforming images : 2

description: A macehead is a symbol of power, authority, and an object of destruction. The dog heads could represent food, companionship, warmth, or a guide or visitor to the underworld. Turn the macehead over and there are two horned frogs, a good source of a hallucinogenic drug. The poison allowed a shaman access to other worlds. The frog is associated with renewal, change, or transformation and fertility.