DOI: 10.5281/zenodo.3893218
title: Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis

description: This dataset contains raw qMRI data and the corresponding calculated relaxation time maps, reference data and an example MATLAB script demonstrating how to access the data, comprising study: <strong>Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis </strong> Journal of Orthopaedic Research | DOI: https://doi.org/10.1002/jor.24780 Kajabi Abdul Wahed*(1,2), Casula Victor(1,2), Sarin Jaakko K.(3,4), Ketola Juuso H.(1), Nykänen Olli(3), te Moller Nikae C.R.(5), Mancini Irina A.D.(5), Visser Jetze(6), Brommer Harold(5), van Weeren P. René(5), Malda Jos(5,6), Töyräs Juha(3,4,7), Nieminen Miika T.(1,2,8), Nissi Mikko J.*(1,3) Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland Department of Applied Physics, University of Eastern Finland, Kuopio, Finland Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands Department of Orthopaedics, University Medical Center Utrecht, The Netherlands School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland *Corresponding authors:<br> Mikko J. Nissi<br> Department of Applied Physics,<br> University of Eastern Finland<br> POB 1627,<br> FI-70211, Kuopio, Finland<br> mikko.nissi@uef.fi<br> +358-50-5955517 Abdul Wahed Kajabi<br> Research Unit of Medical Imaging, Physics and Technology,<br> University of Oulu<br> POB 50,<br> FI-90029, Oulu, Finland<br> abdul.kajabi@oulu.fi<br> +358-50-3037425 Keywords: cartilage, post-traumatic, osteoarthritis, quantitative MRI, relaxation times The file "Pony_AllData.mat" contains all the data of the study. The main struct variable in the file ("all_data") contains several fields storing all the data per sample. In the following, brief descriptions for the main subfields are given: name: contains generic name of the sample qMRI_Data: contains qMRI raw data, the corresponding relaxation time maps and normalized cartilage full-thickness ROI profiles calcROI_Data: contains ROIs used to calculate the relaxation time maps analysisROI_Data: ROIs used for the analysis DD_prof and interpDD_prof: Original and interpolated profiles for proteoglycan content (Optical Density) PLM_prof and interpPLM_prof: Original and interpolated profiles for collagen fiber orientation (Polarized Light Microscopy) E_eq and E_dyn: Equilibrium and dynamic moduli of articular cartilage. The example script, "Analysis_script.m" contains a short demonstration on how the data in the struct can be accessed. The script assumes that Aedes (http://aedes.uef.fi) analysis software is available for matlab. (Abdul Wahed Kajabi, 17 Jun 2020)
description: Support from Jane and Aatos Erkko Foundation, the Academy of Finland (grants #285909, #293970, #319440 and #297033), Dutch Arthritis Foundation, and European Community's Seventh Framework Programme (FP7/2007– 2013) under grant agreement 309962 (HydroZONES).