cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/v1rjpf/w9dtad
title: snk20151115_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997251.v2
title: Expression of kindlin-3 in melanoma cells impedes cell migration and metastasis

description: Kindlins are a small family of 4.1-ezrin-radixin-moesin (FERM)-containing cytoplasmic proteins. Kindlin-3 is expressed in platelets, hematopoietic cells, and endothelial cells. Kindlin-3 promotes integrin activation, clustering and outside-in signaling. Aberrant expression of kindlin-3 was reported in melanoma and breast cancer. Intriguingly, kindlin-3 has been reported to either positively or negatively regulate cancer cell metastasis. In this study, we sought to clarify the expression of kindlin-3 in melanoma cells and its role in melanoma metastasis. Two widely used metastatic mouse and human melanoma cell lines B16-F10 and M10, respectively, were examined and found to lack kindlin-3 mRNA and protein expression. When kindlin-3 was ectopically expressed in these cells, cell migration was markedly reduced. These are attributed to aberrant Rac1 and RhoA activation and overt membrane ruffling. Our data demonstrate for the first time that despite its well established role as a positive regulator of integrin-mediated cell adhesion, aberrant expression of kindlin-3 could lead to imbalanced RhoGTPases signaling that impedes rather than promotes cell migration.
DOI: 10.7910/dvn/v1rjpf/ehohjq
title: snk20150123_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997251.v1
title: Expression of kindlin-3 in melanoma cells impedes cell migration and metastasis

description: Kindlins are a small family of 4.1-ezrin-radixin-moesin (FERM)-containing cytoplasmic proteins. Kindlin-3 is expressed in platelets, hematopoietic cells, and endothelial cells. Kindlin-3 promotes integrin activation, clustering and outside-in signaling. Aberrant expression of kindlin-3 was reported in melanoma and breast cancer. Intriguingly, kindlin-3 has been reported to either positively or negatively regulate cancer cell metastasis. In this study, we sought to clarify the expression of kindlin-3 in melanoma cells and its role in melanoma metastasis. Two widely used metastatic mouse and human melanoma cell lines B16-F10 and M10, respectively, were examined and found to lack kindlin-3 mRNA and protein expression. When kindlin-3 was ectopically expressed in these cells, cell migration was markedly reduced. These are attributed to aberrant Rac1 and RhoA activation and overt membrane ruffling. Our data demonstrate for the first time that despite its well established role as a positive regulator of integrin-mediated cell adhesion, aberrant expression of kindlin-3 could lead to imbalanced RhoGTPases signaling that impedes rather than promotes cell migration.
DOI: 10.6084/m9.figshare.3997221
title: Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis

description: Chemotactic migration is a fundamental behavior of cells and its regulation is particularly relevant in physiological processes such as organogenesis and angiogenesis, as well as in pathological processes such as tumor metastasis. The majority of chemotactic stimuli activate cell surface receptors that belong to the G protein-coupled receptor (GPCR) superfamily. Although the autophagy machinery has been shown to play a role in cell migration, its mode of regulation by chemotactic GPCRs remains largely unexplored. We found that ligand-induced activation of 2 chemotactic GPCRs, the chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, triggers a marked reduction in the biogenesis of autophagosomes, in both HEK-293 and U87 glioblastoma cells. Chemotactic GPCRs exert their anti-autophagic effects through the activation of CAPNs, which prevent the formation of pre-autophagosomal vesicles from the plasma membrane. We further demonstrated that CXCR4- or UTS2R-induced inhibition of autophagy favors the formation of adhesion complexes to the extracellular matrix and is required for chemotactic migration. Altogether, our data reveal a new link between GPCR signaling and the autophagy machinery, and may help to envisage therapeutic strategies in pathological processes such as cancer cell invasion.
DOI: 10.7910/dvn/v1rjpf/ks9ast
title: snk20160115_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997221.v1
title: Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis

description: Chemotactic migration is a fundamental behavior of cells and its regulation is particularly relevant in physiological processes such as organogenesis and angiogenesis, as well as in pathological processes such as tumor metastasis. The majority of chemotactic stimuli activate cell surface receptors that belong to the G protein-coupled receptor (GPCR) superfamily. Although the autophagy machinery has been shown to play a role in cell migration, its mode of regulation by chemotactic GPCRs remains largely unexplored. We found that ligand-induced activation of 2 chemotactic GPCRs, the chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, triggers a marked reduction in the biogenesis of autophagosomes, in both HEK-293 and U87 glioblastoma cells. Chemotactic GPCRs exert their anti-autophagic effects through the activation of CAPNs, which prevent the formation of pre-autophagosomal vesicles from the plasma membrane. We further demonstrated that CXCR4- or UTS2R-induced inhibition of autophagy favors the formation of adhesion complexes to the extracellular matrix and is required for chemotactic migration. Altogether, our data reveal a new link between GPCR signaling and the autophagy machinery, and may help to envisage therapeutic strategies in pathological processes such as cancer cell invasion.
DOI: 10.7910/dvn/v1rjpf/fucdea
title: snk20160131_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/mklt8e
title: snk20160411_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997200
title: Exploring the trade-off between quality and fairness in human partner choice - Data for Raihani & Barclay 2016 RSOS

description: Data in 'Dictator Decisions' describe the decisions made by dictators over two subsequent dictator games, where starting endowment either changed or remained the same.<br><br>Data in 'Chooser Decisions' describe the decisions made by choosers based on the dictator's decision in game 1 and whether endowment was a stable or unstable trait.<br>
DOI: 10.6084/m9.figshare.3997203
title: Eliciting interval beliefs: An experimental study

description: Instructions, software, raw data and <br>codes for data analysis.
DOI: 10.7910/dvn/v1rjpf/j8fo7v
title: snk20160310_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/po39t0
title: snk20160414_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997200.v2
title: Exploring the trade-off between quality and fairness in human partner choice - Data for Raihani & Barclay 2016 RSOS

description: Data in 'Dictator Decisions' describe the decisions made by dictators over two subsequent dictator games, where starting endowment either changed or remained the same.<br><br>Data in 'Chooser Decisions' describe the decisions made by choosers based on the dictator's decision in game 1 and whether endowment was a stable or unstable trait.<br>
DOI: 10.7910/dvn/v1rjpf/zaq4yj
title: snk20160304_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997200.v1
title: Exploring the trade-off between quality and fairness in human partner choice - Data

description: Data in 'Dictator Decisions' describe the decisions made by dictators over two subsequent dictator games, where starting endowment either changed or remained the same.<br><br>Data in 'Chooser Decisions' describe the decisions made by choosers based on the dictator's decision in game 1 and whether endowment was a stable or unstable trait.<br>
DOI: 10.6084/m9.figshare.3997203.v1
title: Eliciting interval beliefs: An experimental study

description: Instructions, software, raw data and <br>codes for data analysis.
DOI: 10.7910/dvn/v1rjpf/jjmbje
title: snk20150608_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997203.v3
title: Eliciting interval beliefs: An experimental study

description: Instructions, software, raw data and <br>codes for data analysis.
DOI: 10.6084/m9.figshare.3997179
title: Antibacterial and anticancer activity of loaded quinazolinone polypyrrole/chitosan silver chloride nanocomposite

description: Polypyrrole/chitosan-silver chloride core shell nanocomposite (AgCl@PPC) was prepared by <i>in situ</i> oxidative polymerization of pyrrole (Py) using ferric chloride in the presence of chitosan (CS) and silver nitrate to develop a carrier and controlled release system for 3-amino-2-phenyl-4(3H)-quinazolinone (I). For sake of comparison, polypyrrole chitosan core shell nanoparticles (PPC) were prepared and loaded by (I). Fourier transform infrared spectroscopy, X-ray diffraction and thermal gravimetric analysis confirm that I was loaded into PPC and AgCl@PPC core shell nanocomposites respectively, through physical interaction. Results revealed that loaded AgCl@PPC and PPC exhibited excellent antibacterial and anticancer efficacy against Ehrlich ascites carcinoma cells.
DOI: 10.6084/m9.figshare.3997203.v2
title: Eliciting interval beliefs: An experimental study

description: Instructions, software, raw data and <br>codes for data analysis.
DOI: 10.7910/dvn/v1rjpf/ay5xkx
title: snk20151012_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997179.v2
title: Antibacterial and anticancer activity of loaded quinazolinone polypyrrole/chitosan silver chloride nanocomposite

description: Polypyrrole/chitosan-silver chloride core shell nanocomposite (AgCl@PPC) was prepared by <i>in situ</i> oxidative polymerization of pyrrole (Py) using ferric chloride in the presence of chitosan (CS) and silver nitrate to develop a carrier and controlled release system for 3-amino-2-phenyl-4(3H)-quinazolinone (I). For sake of comparison, polypyrrole chitosan core shell nanoparticles (PPC) were prepared and loaded by (I). Fourier transform infrared spectroscopy, X-ray diffraction and thermal gravimetric analysis confirm that I was loaded into PPC and AgCl@PPC core shell nanocomposites respectively, through physical interaction. Results revealed that loaded AgCl@PPC and PPC exhibited excellent antibacterial and anticancer efficacy against Ehrlich ascites carcinoma cells.
DOI: 10.7910/dvn/v1rjpf/vwynlz
title: snk20150115_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997179.v1
title: Antibacterial and Anticancer Activity of Loaded Quinazolinone Polypyrrole/Chitosan Silver Chloride Nanocomposite

description: Polypyrrole/chitosan- silver chloride core shell nanocomposite (AgCl@PPC) was prepared by <i>in situ</i> oxidative polymerization of pyrrole (Py) using ferric chloride in the presence of chitosan (CS) and silver nitrate to develop a carrier and controlled release system for 3-amino-2-phenyl-4(3H)-quinazolinone (I). For sake of comparison, polypyrrole chitosan core shell nanoparticles (PPC) were prepared and loaded by (I). Fourier transform infrared spectroscopy, X-ray diffraction and thermal gravimetric analysis confirm that I was loaded into PPC and AgCl@PPC core shell nanocomposites respectively, through physical interaction. Results revealed that loaded AgCl@PPC and PPC exhibited excellent antibacterial and anticancer efficacy against Erlich ascites carcinoma cells.
DOI: 10.7910/dvn/v1rjpf/qwgz2d
title: snk20161011_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/aw0ppq
title: snk20160418_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997149
title: Amadori adducts activated macrophages alter the insulin action in adipocytes .xlsx

description: Dataset of the qPCR and glucose transport
DOI: 10.6084/m9.figshare.3997149.v1
title: Amadori adducts activated macrophages alter the insulin action in adipocytes .xlsx

description: Dataset of the qPCR and glucose transport
DOI: 10.6084/m9.figshare.3997116
title: Data from Estimating Uncertainty in Daily Weather Interpolations: a Bayesian Framework for Developing Climate Surfaces

description: <b>Paper Abstract: </b>Conservation of biodiversity demands comprehension of evolutionary and ecological patterns and processes that occur over vast spatial and temporal scales. A central goal of ecology is to understand the climatic factors that control ecological processes and this has become even more important in the face of climate change. Especially at global scales, there can be enormous uncertainty in underlying environmental data used to explain ecological processes, but that uncertainty is rarely quantified or incorporated into ecological models. In this study a climate-aided Bayesian kriging approach is used to interpolate 20 years of daily meteorological observations (maximum and minimum temperature and precipitation) to a 1 arc-minute grid for the Cape Floristic Region of South Africa. Independent validation data revealed overall predictive performance of the interpolation to have R2 values of 0.90, 0.85, and 0.59 for maximum temperature, minimum temperature, and precipitation, respectively. A suite of ecologically-relevant climate metrics that include the uncertainty introduced by the interpolation were then generated. By providing the high resolution climate metric surfaces and uncertainties, this work facilitates richer and more robust predictive modeling in ecology and bio- geography. These data can be incorporated into ecological models to propagate the uncertainties through to the final predictions.<b>Data Description:</b>NetCDF file with the mean and standard deviation of the daily temperature and precipitation posterior distributions. Metadata is included within the file.<b>Code:</b>Available at https://github.com/adammwilson/BayesianClimate<br><br>
DOI: 10.7910/dvn/v1rjpf/ovmo6v
title: snk20150209_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997095
title: Rawdata eNose sepsis .xlsx

description: In this study we compared fecal samples of preterm infants developing LOS with strictly matched controls by means of Cyranose 320. Fecal samples were obtained prior to clinical onset of LOS. Healthy controls were matched based on center of birth, gestational age, birthweight, days of antibiotics prior to clinical onset, postnatal age and feeding pattern. <br><br><br>
DOI: 10.7910/dvn/v1rjpf/vh5qww
title: snk20151227_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997095.v1
title: Rawdata eNose sepsis .xlsx

description: In this study we compared fecal samples of preterm infants developing LOS with strictly matched controls by means of Cyranose 320. Fecal samples were obtained prior to clinical onset of LOS. Healthy controls were matched based on center of birth, gestational age, birthweight, days of antibiotics prior to clinical onset, postnatal age and feeding pattern. <br><br><br>
DOI: 10.7910/dvn/v1rjpf/a7zhaz
title: snk20151004_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/dqxjdj
title: snk20150725_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3997026
title: OCC triplestore of all the data, as of September 24, 2016

description: <pre>This archive contains the dump of the OpenCitation Corpus (OCC, http://opencitations.net) triplestore (Blazegraph, https://www.blazegraph.com/, licensed in GPLv2) containing all the data of the corpus, and created regularly every month.<br><br>After unzipping the archive, Disk ARchive (DAR, http://dar.linux.free.fr/, a multi-platform archive tool for managing huge amount of data) is needed for recreating the whole structure. For extracting the DAR archive, please run the command<br><br>dar -x [archive-name]<br><br>Where "[archive-name"] is the name of the DAR file without final package number and extension. E.g.:<br><br>dar -x 2016-09-23-triplestore<br><br>Please execute "run.sh" for running the triplestore, and use "stop.sh" for stopping it.<br><br>For further questions, comments, and suggestions please don't hesitate to contact Silvio Peroni at essepuntato@opencitations.net.</pre>
DOI: 10.6084/m9.figshare.3997026.v1
title: OCC triplestore of all the data, as of September 24, 2016

description: <pre>This archive contains the dump of the OpenCitation Corpus (OCC, http://opencitations.net) triplestore (Blazegraph, https://www.blazegraph.com/, licensed in GPLv2) containing all the data of the corpus, and created regularly every month.<br><br>After unzipping the archive, Disk ARchive (DAR, http://dar.linux.free.fr/, a multi-platform archive tool for managing huge amount of data) is needed for recreating the whole structure. For extracting the DAR archive, please run the command<br><br>dar -x [archive-name]<br><br>Where "[archive-name"] is the name of the DAR file without final package number and extension. E.g.:<br><br>dar -x 2016-09-23-triplestore<br><br>Please execute "run.sh" for running the triplestore, and use "stop.sh" for stopping it.<br><br>For further questions, comments, and suggestions please don't hesitate to contact Silvio Peroni at essepuntato@opencitations.net.</pre>
DOI: 10.7910/dvn/v1rjpf/rnhhun
title: snk20150916_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/bmow5c
title: snk20150504_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/zjptiv
title: snk20160605_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/daszep
title: snk20160923_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3996897.v1
title: Illustration From Ada Lovelace Day Panel Event: Championing Success and Avoiding the Echo Chamber

description: An illustration by Jessica Wade from the event ran by Digital Science celebrating Ada Lovelace Day Panel Event: Championing Success and Avoiding the Echo Chamber.
DOI: 10.7910/dvn/v1rjpf/ybcvdr
title: snk20161130_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3996360
title: Supplementary Material for: Haplotype Study in Argentinean Variegate Porphyria Patients

description: <b><i>Background/Aims:</i></b> The porphyrias are genetically heterogeneous diseases, and each mutation is exclusive to one or two families. Among the mutations responsible for variegate porphyria in our country, c.1042_1043insT stands out, since it was described only in Argentina and is present in about 40% of genetically diagnosed families. Thus, we hypothesized the possible existence of a common ancestor for the mutation in our population. <b><i>Methods:</i></b> We conducted a study based on microsatellite (short tandem repeats) haplotypes. <b><i>Results:</i></b> We found a common haplotype in all of the patients carrying the common mutation. The age of the mutation was estimated to be about 375 years. <b><i>Conclusion:</i></b> There is a recent founder effect in our population for this particular genetic alteration in variegate porphyria.
DOI: 10.7910/dvn/v1rjpf/82il1e
title: snk20160621_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/bxctsj
title: snk20150516_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3996360.v1
title: Supplementary Material for: Haplotype Study in Argentinean Variegate Porphyria Patients

description: <b><i>Background/Aims:</i></b> The porphyrias are genetically heterogeneous diseases, and each mutation is exclusive to one or two families. Among the mutations responsible for variegate porphyria in our country, c.1042_1043insT stands out, since it was described only in Argentina and is present in about 40% of genetically diagnosed families. Thus, we hypothesized the possible existence of a common ancestor for the mutation in our population. <b><i>Methods:</i></b> We conducted a study based on microsatellite (short tandem repeats) haplotypes. <b><i>Results:</i></b> We found a common haplotype in all of the patients carrying the common mutation. The age of the mutation was estimated to be about 375 years. <b><i>Conclusion:</i></b> There is a recent founder effect in our population for this particular genetic alteration in variegate porphyria.
DOI: 10.6084/m9.figshare.3996216
title: Supplementary Material for: Another Piece of the Puzzle of Podocyte B7-1 Expression: Lupus Nephritis

description: <b><i>Background/Aims:</i></b> Lupus nephritis (LN) is a frequent complication and a major predictor of poor prognosis of systemic lupus erythematosus. Immune complex deposition and T cell infiltration are crucial events in LN pathogenesis. B7-1 (CD80), normally expressed by antigen-presenting cells, is one of the major co-stimulators of T-cell activation through the binding with its counter-receptors CD28 and cytotoxic T-lymphocyte antigen-4. Unexpectedly, B7-1 induction was described at the podocyte level in patients affected by different renal diseases, including LN. These observations suggested a novel exciting function for B7-1 as a biomarker of podocyte injury, and hence that B7-1 inhibitory drugs could serve as podocyte-targeted treatment of intractable renal diseases. However, subsequent studies hardly questioned the reliability of B7-1 detection assays and the therapeutic efficacy of B7-1 blockade in proteinuric patients, casting doubts on B7-1 expression by podocytes. Here, we thoroughly investigated whether B7-1 was indeed expressed by podocytes in LN, before even considering employing B7-1 blockade in patients with severe manifestations of LN and unfavourable prognosis. <b><i>Methods:</i></b> Applying different immunohistochemical assays with 4 primary antibodies, we analysed kidney biopsies from 42 LN patients at different stages of the disease, and from NZB/NZW mice, an LN model. <b><i>Results:</i></b> B7-1 was not induced in podocytes in human and murine LN; instead its expression was confined to infiltrating inflammatory cells. <b><i>Conclusion:</i></b> B7-1 is not expressed by podocytes in LN. A renoprotective effect of B7-1 blockade in LN patients cannot be ruled out but, if confirmed, cannot be the result of an effect on podocyte B7-1.
DOI: 10.6084/m9.figshare.3996213
title: Expression and methylation of <i>BDNF</i> in the human brain in schizophrenia

description: <b>Objectives:</b> To examine the combined effect of the <i>BDNF</i> Val66Met (rs6265) polymorphism and <i>BDNF</i> DNA methylation on transcriptional regulation of the <i>BDNF</i> gene. <b>Methods:</b> DNA methylation profiles were generated for CpG sites proximal to Val66Met, within <i>BDNF</i> promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects. Val66Met genotypes and <i>BDNF</i> mRNA expression data were generated by transcriptome sequencing. Expression, methylation and genotype data were correlated and examined for association with schizophrenia. <b>Results:</b> There was 43% more of the <i>BDNF</i> V-VIII-IX transcript in schizophrenia samples. <i>BDNF</i> mRNA expression and DNA methylation of seven CpG sites were not associated with schizophrenia after accounting for age and PMI effects. <i>BDNF</i> mRNA expression and DNA methylation were not altered by Val66Met after accounting for age and PMI effects. DNA methylation of one CpG site had a marginally significant positive correlation with mRNA expression in schizophrenia subjects. <b>Conclusions:</b> Schizophrenia risk was not associated with differential <i>BDNF</i> mRNA expression and DNA methylation. A larger age-matched cohort with comprehensive clinical history is required to accurately identify the effects of genotype, mRNA expression and DNA methylation on schizophrenia risk.