cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30397450.v4
title: Antibody Screening and Binding Prediction Analysis Targeting Stx2

description: Shiga toxin (Stx), produced by enterohemorrhagic <i>Escherichia coli</i> (EHEC), is a highly potent exotoxin responsible for severe complications such as hemolytic uremic syndrome (HUS). Among its isoforms, Stx2 exhibits stronger cytotoxicity and poses greater clinical risk, yet no effective therapy currently exists. In this study, two human monoclonal antibodies, YG12-1 and YG12-2, were identified from a phage-display library and systematically characterized using an integrated modeling–validation workflow. Structural modeling with <i>ImmuneBuilder</i> and <i>Rosetta</i> revealed that YG12-2 possessed a longer CDRH3 topology, more short-range hydrogen bonds, and stronger electrostatic complementarity, corresponding to lower binding energy and higher apparent affinity in ELISA.Despite its superior structural stability, YG12-2 exhibited weaker in vivo protection than YG12-1 in a murine peritoneal infection model, where YG12-1 conferred a dose-dependent survival advantage under lethal <i>E. coli</i> O157:H7 challenge. This paradox highlights a non-linear relationship between structural affinity and biological efficacy, emphasizing the importance of functional epitope accessibility and pharmacokinetic behavior in determining neutralization outcomes.Overall, this study demonstrates a computation-guided framework that bridges structural prediction with experimental validation, providing mechanistic insights into Stx2 recognition and suggesting potential structural and functional factors underlying antibody efficacy against Shiga toxin.
DOI: 10.6084/m9.figshare.30397450.v5
title: Antibody Screening and Binding Prediction Analysis Targeting Stx2

description: <b>Background: </b>Shiga toxin (Stx), produced by enterohemorrhagic Escherichia coli (EHEC), is a highly potent exotoxin responsible for severe complications such as hemolytic uremic syndrome (HUS). Among its isoforms, Stx2 exhibits stronger cytotoxicity and poses greater clinical risk, yet no effective therapy currently exists. Methods: In this study, two human monoclonal antibodies, YG12-1 and YG12-2, were identified from a phage display library and systematically characterized using an integrated modeling–validation workflow. <b>Results: </b>Structural modeling with ImmuneBuilder and Rosetta revealed that YG12- 2 possessed a longer CDRH3 topology, more short-range hydrogen bonds, and stronger electrostatic complementarity, corresponding to lower binding energy and higher apparent affinity in ELISA and SPR. Although YG12-2 had a better affinity, YG12-1 shows better protective activity in a murine model of acute peritoneal infection. This paradox highlights a non-linear relationship between structural affinity and biological efficacy, emphasizing the importance of functional epitope accessibility and pharmacokinetic behavior in determining neutralization outcomes. <b>Conlusion: </b>Overall, these results indicated that targeting Stx2 with YG12-1 and YG12-2 could serve as a promising protective strategy against E. coli O157:H7 infection
DOI: 10.21950/yafrc8
title: Federico-Tena World Population Historical Database : Ethiopia

description: Project developed by Giovanni Federico (New York University Abu Dhabi) and Antonio Tena Junguito (Universidad Carlos III de Madrid). Dataset: Ethiopia
description: Microsoft Excel
description: Web site: <strong>https://www.uc3m.es/investigacion/federico-tena-population</strong>



<strong>SEE MAP</strong>
DOI: 10.17897/sh1x-0s73
title: GeoBasis Nuuk - Automatic photo monitoring - K1

description: The automatic camera K1 is placed 300 m.a.s.l. at the mountain South of the fen close to the M300 station (Meteorology). The photos cover the fen, the outer part of the Kobbefjord valley and the very end of the fjord. Photos are captured once a day from October to March (13.00, WGWT) and three times a day from March-October (10.00, 13.00 and 16.00, WGWT). Camera was repositioned in 2009. Systems used: 2007-2011: HP Photosmart E427 6.9 mm camera, Time Guard timer, EL11, 2011-2013: Canon EOS camera, triggerbox, 2013-: Canon EOS camera, triggerbox controlled by CamBoxControl. Please contact the GeoBasis Nuuk manager for the photos. Automatic photo monitoring:Automatic photo monitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.13130/rd_unimi/gr9d83/gvcblr
title: AR list.xlsx.pdf

description: List of AR events
DOI: 10.13130/rd_unimi/gr9d83/m3hyfc
title: 1980_1989_AR.nc

description: Gridded AR dataset (objects shape and axis) from 1980 to 1989
DOI: 10.17897/bfnf-8740
title: GeoBasis Nuuk - Automatic photo monitoring - K2

description: The automatic camera K2 is placed 300 m.a.s.l. at the mountain South of the fen close to the M300 station (Meteorology). The photos cover the South Valley (in the direction of the Ameralik fjord). Photos are captured once a day from October to March (13.00, WGWT) and three times a day from March-October (10.00, 13.00 and 16.00, WGWT). Camera was repositioned in 2009. Systems used: 2007-2011: HP Photosmart E427 6.9 mm camera, Time Guard timer, EL11, 2011-2013: Canon EOS camera, triggerbox, 2013-: Canon EOS camera, triggerbox controlled by CamBoxControl. Please contact the GeoBasis Nuuk manager for the photos. Automatic photo monitoring:Automatic photo monitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.13130/rd_unimi/gr9d83/874pol
title: 2010_2019_AR.nc

description: Gridded AR dataset (objects shape and axis) from 2010 to 2019
DOI: 10.13130/rd_unimi/gr9d83/nph2hr
title: 1970_1979_AR.nc

description: Gridded AR dataset (objects shape and axis) from 1970 to 1979
DOI: 10.17897/4f6c-xj50
title: GeoBasis Nuuk - Automatic photo monitoring - K3

description: The automatic camera K3 is placed 500 m.a.s.l. at the mountain South of the fen close to the M500 station (Meteorology). The photos cover the inner part of Kobbefjord and the outer part of the Kobbefjord Valley. Photos are captured once a day (13.00, WGWT) all year. System used: 2007-: HP Photosmart E427 6.9 mm camera, Time Guard timer, EL11. Please contact the GeoBasis Nuuk manager for the photos. Automatic photo monitoring:Automatic photo monitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.13130/rd_unimi/gr9d83/4eyk5p
title: 1961_1969_AR.nc

description: Gridded AR dataset (objects shape and axis) from 1961 to 1969
DOI: 10.17897/f6jk-jc90
title: GeoBasis Nuuk - Automatic photo monitoring - K4

description: The automatic camera K4 is placed 500 m.a.s.l. at the mountain South of the fen close to the M500 station (Meteorology). The photos cover part of Badesø, the Qassi Valley and the Qassi Lake. Photos are captured once a day (13.00, WGWT) all year. Camera was repositioned in 2009. System used: 2007-: HP Photosmart E427 6.9 mm camera, Time Guard timer, EL11. Please contact the GeoBasis Nuuk manager for the photos. Automatic photo monitoring:Automatic photo monitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.13130/rd_unimi/gr9d83/xtxzid
title: 2000_2009_AR.nc

description: Gridded AR dataset (objects shape and axis) from 2000 to 2009
DOI: 10.13130/rd_unimi/gr9d83/kl9vsv
title: 2020_2024_AR.nc

description: Gridded AR dataset (objects shape and axis) from 2020 to 2024
DOI: 10.13130/rd_unimi/gr9d83/sbaenb
title: 1990_1999_AR.nc

description: Gridded AR dataset (objects shape and axis) from 1990 to 1999
DOI: 10.17897/r3r8-fz13
title: GeoBasis Nuuk - Automatic photo monitoring - K5

description: The automatic camera K5 is placed 800 m.a.s.l. at the mountain north of Badesø. The photos cover most of Badesø, part of the Qassi Valley and Langesø. Photos are captured once a day (13.00 WGWT) all year. Camera was repositioned in 2009. System used: 2007-2014: HP Photosmart E427 6.9 mm camera, Time Guard timer, EL11, 2014-: Canon EOS camera, trigger box controlled by CamBoxControl. Please contact the GeoBasis Nuuk manager for the photos. Automatic photo monitoring:Automatic photo monitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.13130/rd_unimi/gr9d83/078bkt
title: plot_2000-2009.tgz

description: Images of AR (IVT and shape), from 2000 to 2009
DOI: 10.17897/6fsb-m131
title: GeoBasis Nuuk - Automatic photo monitoring - K6

description: The automatic camera K6 is placed 800 m.a.s.l. at the mountain north of Badesø. The photos cover the Qassi lake. Photos are captured once a day (13.00 WGWT) all year. Camera was repositioned in 2009. System used: 2007-2015: HP Photosmart E427 6.9 mm camera, Time Guard timer, EL11, 2015-: Canon EOS camera, trigger box. Please contact the GeoBasis Nuuk manager for the photos. Automatic photo monitoring:Automatic photo monitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.13130/rd_unimi/gr9d83/f5iouf
title: plot_2010-2019.tgz

description: Images of AR (IVT and shape), from 2010 to 2019
DOI: 10.13130/rd_unimi/gr9d83/gzgw6s
title: plot_1980-1989.tgz

description: Images of AR (IVT and shape), from 1980 to 1989
DOI: 10.13130/rd_unimi/gr9d83/sfwwsl
title: plot_2020-2024.tgz

description: Images of AR (IVT and shape), from 2020 to 2024
DOI: 10.13130/rd_unimi/gr9d83/xlxsfo
title: plot_1961-1969.tgz

description: Images of AR (IVT and shape), from 1961 to 1969
DOI: 10.17897/7zme-8h97
title: GeoBasis Nuuk - Fluxmonitoring - AutochambersFen

description: The Methane station (LGR) measures the methane and CO2 fluxes between soil and atmosphere in the fen during the field season (app. end of May until mid-October). The station was established in 2007 in the fen close to the InteractFen (Meteorology, Soil Properties, Snow Properties), EddyFen (Flux Monitoring) and SoilFen (Meteorology, Soil Properties) stations, where the soil is very wet and there is up to more than 1 m of peat. The system consists of six automatic chambers that open and close over a cycle of one hour. When a chamber closes an analyzer monitors the CO2 and CH4 concentration within the closed chamber. Comments: In 2014 chamber 3 and 4 were relocated to new spots and got new tubing. In 2016 the lids got renovated and chamber 1, 2, 5 and 6 got new tubing. 2019: Chambers 1, 2, 3 were exchanged with new chambers on same locations. 2020: Chambers 4, 5 and 6 were exchanged with new chambers on same locations. In 2019-2021 the station suffered from various problems causing gaps in data. The station was closed after the field season 2021. Fluxmonitoring:Fluxmonitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.5281/zenodo.18347889
title: Data associated to "Hydrodynamic stability and pattern formation in hexatic epithelial layers"

description: Data associated to:

Josep-Maria Armengol-Collado, Leonardo Puggioni, Livio N. Carenza, and Luca Giomi, Hydrodynamic stability and pattern formation in hexatic epithelial layers, PRX Life 2026 https://doi.org/10.1103/zqx9-t89j 

Zip file containg the data used to produce Figs 3-4-6-7-8. More info in the file Readme.txt
DOI: 10.13130/rd_unimi/gr9d83/znueuq
title: plot_1970-1979.tgz

description: Images of AR (IVT and shape), from 1970 to 1979
DOI: 10.17897/sm0m-kc26
title: GeoBasis Nuuk - Fluxmonitoring - EddyFen

description: The EddyFen station measures carbon dioxide fluxes via eddy covariance method in a low Arctic fen site (40 m.a.s.l) close to InteractFen (Meteorology, Soil Properties, Snow Properties; 2011-) and SoilFen (Meteorology, Soil Properties; 2007-) and the former station AutochambersFen (Flux Monitoring; 2007-2021). The station was established in 2007 and originally instrumented with a LI7000 CO2/H2O analyzer and Gill 1210R3 sonic anemometer (2007-2018). In 2018 the station was relocated a few meters and upgraded with a LI7200RS closed-path gas analyzer and a SmartFlux2 processing system (2018-). Due to the relocation in 2018, the CO2 flux time series are divided into two datasets (pre-2018 and post-2018). This dataset contains quality-controlled fluxes of CO2, LE and H; wind speed and -direction from 2007-2018. The station was logging at a frequency of 20 Hz and data are aggregated as 30-minute averages (UTC-3 West Greenlandic Winter Time). Data were collected only during the summer field season (approximately May–October) due to winter power limitations. Post-2018 time series containing CO2 flux data is available under the dataset under "EddyFen_2018-". Fluxmonitoring:Fluxmonitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.5281/zenodo.18347888
title: Data associated to "Hydrodynamic stability and pattern formation in hexatic epithelial layers"

description: Data associated to:

Josep-Maria Armengol-Collado, Leonardo Puggioni, Livio N. Carenza, and Luca Giomi, Hydrodynamic stability and pattern formation in hexatic epithelial layers, PRX Life 2026 https://doi.org/10.1103/zqx9-t89j 

Zip file containg the data used to produce Figs 3-4-6-7-8. More info in the file Readme.txt
DOI: 10.13130/rd_unimi/gr9d83/aadjuc
title: README.txt

description: Readme file
DOI: 10.13130/rd_unimi/gr9d83/pdomol
title: plot_1990-1999.tgz

description: Images of AR (IVT and shape), from 1990 to 1999
DOI: 10.17897/cdwm-tv93
title: GeoBasis Nuuk - Fluxmonitoring - EddyFen_2018-

description: The EddyFen station measures carbon dioxide- and methane fluxes via eddy covariance method in a low Arctic fen site (40 m.a.s.l) close to InteractFen (Meteorology, Soil Properties, Snow Properties; 2011-) and SoilFen (Meteorology, Soil Properties; 2007-) and the former station AutochambersFen (Flux Monitoring; 2007-2021). The station was established in 2007 and originally instrumented with a LI7000 CO2/H2O analyzer and Gill 1210R3 sonic anemometer (2007-2018). In 2018 the station was relocated a few meters and upgraded with a LI7200RS closed-path gas analyzer and a SmartFlux2 processing system (2018-). The Gill HS-50 sonic anemometer replaced the previous model in 2019 (2019-), and an LI7700 open-path CH4 Analyzer was added in 2024 (2024-). Due to the relocation in 2018, the CO2 flux time series are divided into two datasets (pre-2018 and post-2018). This dataset contains quality-controlled fluxes of CO2, LE and H; CO2- and H2O concentrations; friction velocity; wind speed and -direction from 2018 onwards. In 2021 the station was labelled ICOS (Integrated Carbon Observation System) associated, and data are processed following ICOS standards, with a logging frequency of 20 Hz and aggregated as 30-minute averages (UTC-3 West Greenlandic Winter Time). From 2007 to 2023, data were collected only during the summer field season (approximately May–October) due to winter power limitations. Since 2024, continuous year-round data collection has been enabled, though occasional data gaps remain in the dark months from November to February. Pre-2018 time series containing CO2 flux data is available under the dataset under "EddyFen" and CH4 fluxes are expected to be made available as a separate dataset soon. Fluxmonitoring:Fluxmonitoring GeoBasis Nuuk:The GeoBasis monitoring programme focuses on selected abiotic characteristics in order to describe the state of Greenlandic terrestrial environments and their potential feedback effects in a changing climate. Monitored plot data is up-scaled to a landscape level and is used to improve ecosystem models to be able to quantify these feedback mechanisms. The GeoBasis programme provides an active response to recommendations in international assessments such as ACIA and SWIPA; and is continuously being adapted based on AMAP and other international founded recommendations. Furthermore, the GeoBasis programme is directly involved in several international networks and research projects (e.g. the Circumpolar Active Layer Monitoring (CALM) programme, the Nordic Centre of Excellence DEFROST, the Danish Centre of Excellence CENPERM, the EU-projects PAGE21 and INTERACT, and the Arctic Research Centre at Aarhus University). The GeoBasis programme is divided into a number of sub-groups, including:
DOI: 10.5281/zenodo.18374114
title: Polynomial Time Convergence for NP-Complete Problems via Bounded Carry Algebra: A Hierarchical Reduction Algorithm for the Subset Sum Problem

description: This paper presents a deterministic, polynomial-time algorithm (Hierarchical Carry Reduction: HCR) for the Subset Sum Problem, a classic NP-complete problem. By mapping integer sets into a vector space and analyzing carry transitions across hierarchical layers, we demonstrate that the number of active states is strictly bounded by O(n).