cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6073/pasta/c62e1a04e9a021bd5549274b9f34a8a1
title: Autumnal Litter Input in DIRT Litter Manipulation Experiment at Harvard Forest 2008

description: Climate change will alter forest ecosystem productivity, changing the quantity and quality of detrital inputs to soil and altering rates of soil organic matter (SOM) accumulation and stabilization. To examine changes in forest soil SOM pools, we have used the Detritus Input and Removal Treatments (DIRT) Project to alter organic matter input rates and sources (roots, leaves) to soils, allowing us to measure contributions of organic matter sources to long-term SOM storage at five temperate forests (Harvard Forest, HJ Andrews, Bousson (PA) Experimental Forest (BEF), U. Michigan Biological Station (UMBS), Síkfokut ILTER, Hungary). Organic matter inputs are altered by excluding or adding leaf inputs, or by excluding roots from forested plots. Soil respiration partitioning at HF, BEF, and UMBS shows that soil fertility controls the allocation of C to above- and belowground tissue. At UMBS, glacial outwash sandy soils are extremely low in N, and C released from root respiration plus root litter decomposition is 87% of total soil respiration. Conversely, at the N-rich BEF site, total belowground sources of CO2 are only 61% of soil respiration, with 47% attributed to root litter. These data suggest that at BEF, leaf litter, comprising only 39% of soil respiration, would be a more important source of long-term SOM than root litter. However, soil chemistry and radiocarbon data have shown us that long-term soil C storage is complex. The year 2010 represents the 20-year anniversary of the initiation of DIRT treatments at the Harvard Forest (2010), and we are therefore planning to conduct systematic sampling campaigns for a comprehensive study of changes in SOM quality after long-term manipulation of inputs. One objective is to quantify how 20 years of litter input alterations have affected SOM quantity and quality at the surface (0-20 cm) and deeper in the soil profile (20-100 cm). To uderstand these changes, we need to quantify the quantity and quality of aboveground litter inputs. Total aboveground litter inputs were 300.4 + 8.9 (SE, n=21) g m-2. In congruence with the data for aboveground biomass, black oak contributed the dominant mass (73.9%) of litter inputs; red maple and paper birch together contributed 23.26% of the total. Six other tree species collectively constituted the balance of litter inputs.
DOI: 10.34740/kaggle/dsv/2363134
title: EU recovery and resilience facility current status
DOI: 10.5281/zenodo.5017874
title: Hydrogen sulfide release via the ACE inhibitor Zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis

description: The current strategies to reduce intimal hyperplasia (IH) principally rely on local drug delivery, in endovascular approach. The oral angiotensin converting enzyme inhibitor (ACEi) Zofenopril has additional effects compared to other non-sulfyhydrated ACEi to prevent intimal hyperplasia and restenosis. Given the number of patients treated with ACEi worldwide, these findings call for further prospective clinical trials to test the benefits of sulfhydrated ACEi over classic ACEi for the prevention of restenosis in hypertensive patients. Abstract Objectives Hypertension is a major risk factor for intimal hyperplasia (IH) and restenosis following vascular and endovascular interventions. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, limits restenosis. While there is no clinically available pure H2S releasing compound, the sulfhydryl-containing angiotensin-converting enzyme inhibitor Zofenopril is a source of H2S. Here, we hypothesized that Zofenopril, due to H2S release, would be superior to other non-sulfhydryl containing angiotensin converting enzyme inhibitor (ACEi), in reducing intimal hyperplasia in the context of hypertension. Materials Spontaneously hypertensive male Cx40 deleted mice (Cx40-/-) or WT littermates were randomly treated with Enalapril 20 mg (Mepha Pharma) or Zofenopril 30 mg (Mylan SA). Discarded human vein segments and primary human smooth muscle cells (SMC) were treated with the active compound Enalaprilat or Zofenoprilat. Methods IH was evaluated in mice 28 days after focal carotid artery stenosis surgery and in human vein segments cultured for 7 days ex vivo. Human primary smooth muscle cell (SMC) proliferation and migration were studied in vitro. Results Compared to control animals (intima/media thickness=2.3±0.33), Enalapril reduced IH in Cx40-/- hypertensive mice by 30% (1.7±0.35; p=0.037), while Zofenopril abrogated IH (0.4±0.16; p&lt;.0015 vs. Ctrl and p&gt;0.99 vs. sham-operated Cx40-/-mice). In WT normotensive mice, enalapril had no effect (0.9665±0.2 in control vs 1.140±0.27; p&gt;.99), while Zofenopril also abrogated IH (0.1623±0.07, p&lt;.008 vs. Ctrl and p&gt;0.99 vs. sham-operated WT mice). Zofenoprilat, but not Enalaprilat, also prevented intimal hyperplasia in human veins segments ex vivo. The effect of Zofenopril on carotid and SMC correlated with reduced SMC proliferation and migration. Zofenoprilat inhibited the MAPK and mTOR pathways in SMC and human vein segments. Conclusion Zofenopril provides extra beneficial effects compared to non-sulfhydryl ACEi to reduce SMC proliferation and restenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.
DOI: 10.5281/zenodo.3891375
title: Hydrogen sulfide release via the ACE inhibitor Zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis

description: The current strategies to reduce intimal hyperplasia (IH) principally rely on local drug delivery, in endovascular approach. The oral angiotensin converting enzyme inhibitor (ACEi) Zofenopril has additional effects compared to other non-sulfyhydrated ACEi to prevent intimal hyperplasia and restenosis. Given the number of patients treated with ACEi worldwide, these findings call for further prospective clinical trials to test the benefits of sulfhydrated ACEi over classic ACEi for the prevention of restenosis in hypertensive patients. Abstract Objectives Hypertension is a major risk factor for intimal hyperplasia (IH) and restenosis following vascular and endovascular interventions. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, limits restenosis. While there is no clinically available pure H2S releasing compound, the sulfhydryl-containing angiotensin-converting enzyme inhibitor Zofenopril is a source of H2S. Here, we hypothesized that Zofenopril, due to H2S release, would be superior to other non-sulfhydryl containing angiotensin converting enzyme inhibitor (ACEi), in reducing intimal hyperplasia in the context of hypertension. Materials Spontaneously hypertensive male Cx40 deleted mice (Cx40-/-) or WT littermates were randomly treated with Enalapril 20 mg (Mepha Pharma) or Zofenopril 30 mg (Mylan SA). Discarded human vein segments and primary human smooth muscle cells (SMC) were treated with the active compound Enalaprilat or Zofenoprilat. Methods IH was evaluated in mice 28 days after focal carotid artery stenosis surgery and in human vein segments cultured for 7 days ex vivo. Human primary smooth muscle cell (SMC) proliferation and migration were studied in vitro. Results Compared to control animals (intima/media thickness=2.3±0.33), Enalapril reduced IH in Cx40-/- hypertensive mice by 30% (1.7±0.35; p=0.037), while Zofenopril abrogated IH (0.4±0.16; p&lt;.0015 vs. Ctrl and p&gt;0.99 vs. sham-operated Cx40-/-mice). In WT normotensive mice, enalapril had no effect (0.9665±0.2 in control vs 1.140±0.27; p&gt;.99), while Zofenopril also abrogated IH (0.1623±0.07, p&lt;.008 vs. Ctrl and p&gt;0.99 vs. sham-operated WT mice). Zofenoprilat, but not Enalaprilat, also prevented intimal hyperplasia in human veins segments ex vivo. The effect of Zofenopril on carotid and SMC correlated with reduced SMC proliferation and migration. Zofenoprilat inhibited the MAPK and mTOR pathways in SMC and human vein segments. Conclusion Zofenopril provides extra beneficial effects compared to non-sulfhydryl ACEi to reduce SMC proliferation and restenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.
DOI: 10.6084/m9.figshare.14828577
title: The orignal data of NCS.xlsx

description: These data are the color depths of some samples of NCS INDEX 1950 Original calculated by 5 color depth formulas, and all the specimens were measured by applying an X-Rite Color i7.
DOI: 10.6073/pasta/8426383088008e9172d76cb62bf301f4
title: Ecophysiology of Carnivorous Plants Worldwide 1980-2011

description: Identification of trade-offs among physiological and morphological traits and their use in cost-benefit models and ecological or evolutionary optimization arguments have been hallmarks of ecological analysis for at least 50 years. Carnivorous plants are model systems for studying a wide range of ecophysiological and ecological processes and the application of a cost-benefit model for the evolution of carnivory by plants has provided many novel insights into trait-based cost-benefit models. Central to the cost-benefit model for the evolution of botanical carnivory is the relationship between nutrients and photosynthesis; of primary interest is how carnivorous plants efficiently obtain scarce nutrients that are supplied primarily in organic form as prey, digest and mineralize them so that they can be readily used, and allocate them to immediate versus future needs. Most carnivorous plants are terrestrial - they are rooted in sandy or peaty wetland soils - and most studies of cost-benefit trade-offs in carnivorous plants are based on terrestrial carnivorous plants. However more than 10% of carnivorous plants are unrooted aquatic plants. By examining data published between 1980 and 2011, we ask whether the cost-benefit model applies equally well to aquatic carnivorous plants and what general insights into trade-off models are gained by this comparison. Nutrient limitation is more pronounced in terrestrial carnivorous plants, which also have much lower growth rates and much higher ratio of dark respiration to photosynthetic rates than aquatic carnivorous plants. Phylogenetic constraints on ecophysiological trade-offs among carnivorous plants remain unexplored. Despite differences in detail, the general cost-benefit framework continues to be of great utility in understanding the evolutionary ecology of carnivorous plants. We provide a research agenda that if implemented would further our understanding of ecophysiological trade-offs in carnivorous plants and also would provide broader insights into similarities and differences between aquatic and terrestrial plants of all types.
DOI: 10.6073/pasta/4c8cda70ff0f8bf6456ca060d6e7d8c6
title: Decomposition Dynamics in the Sarracenia Purpurea Microecosystem at Harvard Forest 2010

description: Ecological communities show great variation in species richness, composition and food web structure across similar and diverse ecosystems. Knowledge of how this biodiversity relates to ecosystem functioning is important for understanding the maintenance of diversity and the potential effects of species losses or gains on ecosystems. While research often focuses on how variation in species richness influences ecosystem processes, assessing species richness in a food web context can provide further insight into the relationship between diversity and ecosystem functioning and provide potential mechanisms underpinning this relationship. Here, we assessed how species richness and trophic diversity affect decomposition rates in a complete aquatic food web: the five trophic level web that occurs within water-filled leaves of the northern pitcher plant, Sarracenia purpurea. We identified a trophic cascade in which top-predators - larvae of the pitcher-plant mosquito - indirectly increased bacterial decomposition by preying on bactivorous protozoa. Our data also revealed a facultative relationship in which larvae of the pitcher-plant midge increased bacterial decomposition by shredding detritus. These important interactions occur only in food webs with high trophic diversity, which in turn only occurs in food webs with high species richness. We show that species richness and trophic diversity underlie strong linkages between food web structure and dynamics that influence ecosystem functioning. The importance of trophic diversity and species interactions in determining how biodiversity relates to ecosystem functioning suggests that simply focusing on species richness does not give a complete picture as to how ecosystems may change with the loss or gain of species.
DOI: 10.6084/m9.figshare.14828733.v1
title: The orignal data of NCS.xlsx

description: These data are the color depths of some samples of NCS INDEX 1950 Original calculated by 5 color depth formulas, and all the specimens were measured by applying an X-Rite Color i7.
DOI: 10.6084/m9.figshare.14828733
title: The orignal data of NCS.xlsx

description: These data are the color depths of some samples of NCS INDEX 1950 Original calculated by 5 color depth formulas, and all the specimens were measured by applying an X-Rite Color i7.
DOI: 10.5281/zenodo.3492198
title: Data and code: Evaluation of the General Practice Pharmacist (GPP) intervention to optimise prescribing in Irish primary care: a non‐randomised pilot study

description: This is a dataset and Stata analytical code relating to prescribing issues identified in the GPP pilot feasibility study. The paper reporting this study has been published as follows: Cardwell K, Smith SM, Clyne B on behalf of the General Practice Pharmacist (GPP) Study Group, et al. Evaluation of the General Practice Pharmacist (GPP) intervention to optimise prescribing in Irish primary care: a non-randomised pilot study. BMJ Open 2020;10:e035087. doi: 10.1136/bmjopen-2019-035087 The abstract of the study is included below: <strong>Objective:</strong> Limited evidence suggests integration of pharmacists into the general practice team could improve medicines management for patients, particularly those with multimorbidity and polypharmacy. This study aimed to develop and assess the feasibility of an intervention involving pharmacists, working within general practices, to optimise prescribing in Ireland. <strong>Design:</strong> Non-randomised pilot study <strong>Setting:</strong> Primary care in Ireland <strong>Participants:</strong> Four general practices, purposively sampled and recruited to reflect a range of practice sizes and demographic profiles. <strong>Intervention:</strong> A pharmacist joined the practice team for six months (10 hours/week) and undertook medication reviews (face-to-face or chart-based) for adult patients, provided prescribing advice, supported clinical audits, and facilitated practice-based education. <strong>Outcome measures:</strong> Anonymised practice-level medication (e.g. medication changes) and cost data were collected. Patient-Reported Outcome Measure (PROM) data were collected on a subset of older adults (aged ≥65 years) with polypharmacy using patient questionnaires, before and six weeks after medication review by the pharmacist. <strong>Results:</strong> Across four practices, 787 patients were identified as having 1,521 prescribing issues by the pharmacists. Issues relating to potentially inappropriate or high-risk prescribing were addressed most often by the prescriber (51.8%), compared to cost-related issues (7.5%). Medication changes made during the study equated to approximately €57,000 in cost savings assuming they persisted for 12 months. Ninety-six patients aged ≥65 years with polypharmacy were recruited from the four practices for PROM data collection and 64 (66.7%) were followed up. There were no changes in patients’ treatment burden or attitudes to deprescribing following medication review, and there were conflicting changes in patients' self-reported quality of life. <strong>Conclusions:</strong> This non-randomised pilot study demonstrated that an intervention involving pharmacists, working within general practices is feasible to implement and has potential to improve prescribing quality. This study provides rationale to conduct a randomised controlled trial to evaluate the clinical and cost-effectiveness of this intervention.
DOI: 10.5281/zenodo.3492197
title: Data and code: Evaluation of the General Practice Pharmacist (GPP) intervention to optimise prescribing in Irish primary care: a non‐randomised pilot study

description: This is a dataset and Stata analytical code relating to prescribing issues identified in the GPP pilot feasibility study. The paper reporting this study has been published as follows: Cardwell K, Smith SM, Clyne B on behalf of the General Practice Pharmacist (GPP) Study Group, et al. Evaluation of the General Practice Pharmacist (GPP) intervention to optimise prescribing in Irish primary care: a non-randomised pilot study. BMJ Open 2020;10:e035087. doi: 10.1136/bmjopen-2019-035087 The abstract of the study is included below: <strong>Objective:</strong> Limited evidence suggests integration of pharmacists into the general practice team could improve medicines management for patients, particularly those with multimorbidity and polypharmacy. This study aimed to develop and assess the feasibility of an intervention involving pharmacists, working within general practices, to optimise prescribing in Ireland. <strong>Design:</strong> Non-randomised pilot study <strong>Setting:</strong> Primary care in Ireland <strong>Participants:</strong> Four general practices, purposively sampled and recruited to reflect a range of practice sizes and demographic profiles. <strong>Intervention:</strong> A pharmacist joined the practice team for six months (10 hours/week) and undertook medication reviews (face-to-face or chart-based) for adult patients, provided prescribing advice, supported clinical audits, and facilitated practice-based education. <strong>Outcome measures:</strong> Anonymised practice-level medication (e.g. medication changes) and cost data were collected. Patient-Reported Outcome Measure (PROM) data were collected on a subset of older adults (aged ≥65 years) with polypharmacy using patient questionnaires, before and six weeks after medication review by the pharmacist. <strong>Results:</strong> Across four practices, 787 patients were identified as having 1,521 prescribing issues by the pharmacists. Issues relating to potentially inappropriate or high-risk prescribing were addressed most often by the prescriber (51.8%), compared to cost-related issues (7.5%). Medication changes made during the study equated to approximately €57,000 in cost savings assuming they persisted for 12 months. Ninety-six patients aged ≥65 years with polypharmacy were recruited from the four practices for PROM data collection and 64 (66.7%) were followed up. There were no changes in patients’ treatment burden or attitudes to deprescribing following medication review, and there were conflicting changes in patients' self-reported quality of life. <strong>Conclusions:</strong> This non-randomised pilot study demonstrated that an intervention involving pharmacists, working within general practices is feasible to implement and has potential to improve prescribing quality. This study provides rationale to conduct a randomised controlled trial to evaluate the clinical and cost-effectiveness of this intervention.
DOI: 10.25919/5f85-pc48
title: Parkes observations for project P1101 semester 2021APRS_05

description: We propose to carry out fortnightly monitoring of a very active repeater, FRB~190520, with the Parkes UWL system. Our current observations show that FRB~190520 is not only the most active FRB that can be observed with Parkes, but also shows unique behaviour at 2 to 3 GHz frequency. This makes UWL the ideal instrument to carry out in-depth studies of this repeating FRB. With this program, we expect to detect a large sample of bursts from FRB~190520, and in collaboration with the FAST telescope we will search for potential periodicity and study emission properties over an extremely wide bandwidth with high sensitivity.
DOI: 10.5281/zenodo.5018007
title: Raw data for "Signatures of Intra- and Intermolecular Vibrational Coupling in Halogenated Liquids Revealed by Two-Dimensional Raman-Terahertz Spectroscopy"

description: Raw data for "Signatures of Intra- and Intermolecular Vibrational Coupling in Halogenated Liquids Revealed by Two-Dimensional Raman-Terahertz Spectroscopy"
DOI: 10.5281/zenodo.5018006
title: Raw data for "Signatures of Intra- and Intermolecular Vibrational Coupling in Halogenated Liquids Revealed by Two-Dimensional Raman-Terahertz Spectroscopy"

description: Raw data for "Signatures of Intra- and Intermolecular Vibrational Coupling in Halogenated Liquids Revealed by Two-Dimensional Raman-Terahertz Spectroscopy"
DOI: 10.5281/zenodo.5016572
title: Pano3D: GibsonV2 Tiny-Fullplus Filmic High Resolution

description: Pano3D is a new benchmark for depth estimation from spherical panoramas. Its goal is to drive progress for this task in a consistent and holistic manner. To achieve that we generate a new dataset and integrate evaluation metrics that capture not only depth performance, but also secondary traits like boundary preservation and smoothness. Moreover, Pano3D takes a step beyond typical intra-dataset evaluation schemes to inter-dataset performance assessment. By disentangling generalization to three different axes, Pano3D facilitates proper extrapolation assessment under different out-of-training data conditions. Relying on the Pano3D holistic benchmark for 360 depth estimation we perform an extended analysis and derive a solid baseline for the task.
description: Dataset of color images with shifted camera domain. Corresponding depth and normal maps can found at the respective related repositories.
DOI: 10.5281/zenodo.5016571
title: Pano3D: GibsonV2 Tiny-Fullplus Filmic High Resolution

description: Pano3D is a new benchmark for depth estimation from spherical panoramas. Its goal is to drive progress for this task in a consistent and holistic manner. To achieve that we generate a new dataset and integrate evaluation metrics that capture not only depth performance, but also secondary traits like boundary preservation and smoothness. Moreover, Pano3D takes a step beyond typical intra-dataset evaluation schemes to inter-dataset performance assessment. By disentangling generalization to three different axes, Pano3D facilitates proper extrapolation assessment under different out-of-training data conditions. Relying on the Pano3D holistic benchmark for 360 depth estimation we perform an extended analysis and derive a solid baseline for the task.
description: Dataset of color images with shifted camera domain. Corresponding depth and normal maps can found at the respective related repositories.
DOI: 10.6084/m9.figshare.14740332
title: Raw Data

description: Raw survey data from both 2017 and 2018 surveys "Bridging the Study-Work Chasm"
DOI: 10.6084/m9.figshare.14740332.v1
title: Raw Data

description: Raw survey data from both 2017 and 2018 surveys "Bridging the Study-Work Chasm"
DOI: 10.5281/zenodo.5018033
title: Raw data for "Impact of nuclear quantum effects on the structural inhomogeneity of liquid water"

description: Raw data for "Impact of nuclear quantum effects on the structural inhomogeneity of liquid water"
DOI: 10.5281/zenodo.5018032
title: Raw data for "Impact of nuclear quantum effects on the structural inhomogeneity of liquid water"

description: Raw data for "Impact of nuclear quantum effects on the structural inhomogeneity of liquid water"
DOI: 10.6084/m9.figshare.14336594
title: Excitatory and Inhibitory Inputs during Spontaneous activity

description: Whole- cell recording in voltage clamp, alternately held at the reversal potential for Na/K and Cl to isolate inhibitory and excitatory currents. Each file is a cell from an individual animal. <br><br>