cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24966156.v1
title: Supplementary Material for: Systemic glucose regulation by a hindbrain inhibitory circuit in a mouse model of type 1 diabetes

description: Introduction. Previous work showed that increasing the electrical activity of inhibitory neurons in the dorsal vagal complex (DVC) is sufficient to increase whole-body glucose concentration in normoglycemic mice. Here we tested the hypothesis that deactivating GABAergic neurons in the dorsal hindbrain of hyperglycemic mice decreases synaptic inhibition of parasympathetic motor neurons in the dorsal motor nucleus of the vagus (DMV) and reduces systemic glucose levels. 
Methods. Chemogenetic activation or inactivation of GABAergic neurons in the nucleus tractus solitarius (NTS) was used to assess effects of modulating parasympathetic output on blood glucose concentration in normoglycemic and hyperglycemic mice. Patch-clamp electrophysiology in vitro was used to assess cellular effects of chemogenetic manipulation of NTS GABA neurons.
Results. Chemogenetic activation of GABAergic NTS neurons in from normoglycemic mice increased their action potential firing, resulting in increased inhibitory synaptic input to DMV motor neurons and elevated blood glucose concentration. Deactivation of GABAergic DVC neurons in normoglycemic mice altered their electrical activity but did not alter systemic glucose levels. Conversely, stimulation of GABAergic DVC neurons in mice that were hyperglycemic subsequent to treatment with streptozotocin changed their electrical activity but did not alter whole-body glucose concentration, while deactivation of this inhibitory circuit significantly decreased circulating glucose concentration. Peripheral administration of a brain impermeant muscarinic acetylcholine receptor antagonist abolished these effects. 
Conclusion. Disinhibiting vagal motor neurons decreases hyperglycemia in a mouse model of type 1 diabetes. This inhibitory brainstem circuit emerges as a key parasympathetic regulator of whole-body glucose homeostasis that undergoes functional plasticity in hyperglycemic conditions.
DOI: 10.6084/m9.figshare.24633702
title: CGCGNN datasets

description: A novel graph neural network model called CGCGNN to predict materials property. jdft_3d-8-18-2021.json is Jarvis-DFT dataset. Megnet.json is MP dataset. predicted_mixed_perovskites_computed_entries.tar is perovskites dataset.
DOI: 10.6084/m9.figshare.24633702.v1
title: AAGNN datasets

description: A novel graph neural network model called CGCGNN to predict materials property. jdft_3d-8-18-2021.json is Jarvis-DFT dataset. Megnet.json is MP dataset. predicted_mixed_perovskites_computed_entries.tar is perovskites dataset.
DOI: 10.6084/m9.figshare.24182487.v1
title: <i>NOS1AP</i> genotype and clinical parameters.xlsx

description: <b>Genetic polymorphisms in</b><b><i> NOS1AP</i></b><b> affects insulin secretion in response to exenatide in Chinese patients with type 2 diabetes mellitus</b>
DOI: 10.57841/casdc.0003333
title: 线性泛基因组骨架构建软件(LPGSB)测试数据集
DOI: 10.6084/m9.figshare.22665040.v1
title: Dynamic mechanical response of carbon nanotube yarns and their in situ electrical measurements

description: Carbon nanotube yarns (CNTYs) are outstanding hierarchical fibers with electrical properties that depend on temperature and mechanical stimuli, which makes them attractive as smart materials for sensing applications. In order to better understand the electrical response of CNTYs under a combination of dynamic loading and variations of temperature, their monotonic and cyclic tensile mechanical response, <i>in situ</i> Raman spectroscopy, mechanical hysteresis, and dynamic mechanical analysis (DMA) are investigated herein. The piezoresistivity and thermoresistivity of CNTYs were characterized to correlate the contribution of temperature and strain to the effective electrical response of the CNTY under DMA testing. It was found that the tensile load bearing of the CNTYs is governed mainly by structural changes of its bundles/fibrils, rather than by stretching of the carbon bonds. The large energy dissipation capabilities of the CNTYs arise mainly from friction among their fibrils and bundles, and also due to irreversible morphological changes in their hierarchical structure. The (mechanically constrained) thermoresistive characterization showed that the electrical resistance of the CNTYs decreases with increasing temperature, yielding an average temperature coefficient of resistance of −8.63 × 10<sup>−4</sup> K<sup>−1</sup>. The electrical response of the CNTYs during DMA temperature scans is governed by their thermoresistive response.
DOI: 10.25946/21500178
title: Nepali Ethnographic case study

description: This study provides a more in-depth understanding of the Nepali students’ specific needs and obstacles in achieving happiness and success in both academic and social areas of their lives during their time in Australia. Data was collected via in-depth interviews and field notes taking into consideration the two research questions: 1) What academic and social successes and challenges do Nepali students experience as learners at an Australian university? 2) How can these experiences be explained through the threshold concepts theory?
DOI: 10.25946/21500178.v1
title: Nepali Ethnographic case study

description: This study provides a more in-depth understanding of the Nepali students’ specific needs and obstacles in achieving happiness and success in both academic and social areas of their lives during their time in Australia. Data was collected via in-depth interviews and field notes taking into consideration the two research questions: 1) What academic and social successes and challenges do Nepali students experience as learners at an Australian university? 2) How can these experiences be explained through the threshold concepts theory?
DOI: 10.5281/zenodo.10457242
title: Accessibility Perspectives of Indian Software Professionals

description: This dataset captures the accessibility knowledge, practices of software professionals in the Indian context. The below are the columns: 



A11YKnowldge - A likert scale (5 point) rating of accessibility knowledge 

Domain - The domain within software industry 

Experience - Overall Industry experience 

A11YExperience - Whether have industry accessibility experience or not. If so, the role 

India - Whether location of the responded is India 

CompanyType - Type of company: Product / Service / Hybrid 

CompanySize - Size of the company: Large scale/medium scale/small scale 

CompanyModal - Business modal of the company: B2B / B2C/ C2C / Others 

CompanyInAT - If company delves into production of assitive technologies "Yes" , else a "No" 

ResourcesAvailable - A likert scale (5 point) on how much resources are available on accessibility for employees 

ParticipatedInInclusiveDesign - A boolean variable on if respondant has participated in inclusive design or not 

A11YTesting - How was accessibility testing done.

UserTest - How was user testing done.

StageOfInclusiveDesign - Stage in which inclusive design was practiced - Design / Development ...

A11YStandards - List of accessibility standards followed in the projects 

A11YExpertPresentInTeam - Was there accessibility expertise in the team or not 

ChallengesInA11Y - Challenges in ensuring accessibility 

ResoucesNeeded - Resources needed for making digital products more accessible 

Gender

Qualification

PWD - If identifies as a person with disability 

DisabilityType - If PWD, the type of disability 

KnowAPWD - Whether knows a person with disability
DOI: 10.5281/zenodo.10457243
title: Accessibility Perspectives of Indian Software Professionals

description: This dataset captures the accessibility knowledge, practices of software professionals in the Indian context. The below are the columns: 



A11YKnowldge - A likert scale (5 point) rating of accessibility knowledge 

Domain - The domain within software industry 

Experience - Overall Industry experience 

A11YExperience - Whether have industry accessibility experience or not. If so, the role 

India - Whether location of the responded is India 

CompanyType - Type of company: Product / Service / Hybrid 

CompanySize - Size of the company: Large scale/medium scale/small scale 

CompanyModal - Business modal of the company: B2B / B2C/ C2C / Others 

CompanyInAT - If company delves into production of assitive technologies "Yes" , else a "No" 

ResourcesAvailable - A likert scale (5 point) on how much resources are available on accessibility for employees 

ParticipatedInInclusiveDesign - A boolean variable on if respondant has participated in inclusive design or not 

A11YTesting - How was accessibility testing done.

UserTest - How was user testing done.

StageOfInclusiveDesign - Stage in which inclusive design was practiced - Design / Development ...

A11YStandards - List of accessibility standards followed in the projects 

A11YExpertPresentInTeam - Was there accessibility expertise in the team or not 

ChallengesInA11Y - Challenges in ensuring accessibility 

ResoucesNeeded - Resources needed for making digital products more accessible 

Gender

Qualification

PWD - If identifies as a person with disability 

DisabilityType - If PWD, the type of disability 

KnowAPWD - Whether knows a person with disability
DOI: 10.6084/m9.figshare.24966219
title: Supplementary Material for: Sex-specific appetite regulation of lipocalin-2 in high fat diet-induced obese mice

description: Lipocalin 2 (Lcn2) is a key factor in appetite suppression. However, the effect of Lcn2 on appetite in terms of sex differences has not been thoroughly studied. Methods: Young (3-month-old) whole-body Lcn2 knockout (Lcn2-/-) mice, which were fed normal diet (ND) or high-fat diet (HFD) for eight-weeks to investigate obesity, food intake, serum metabolism, hepatic lipid metabolism, and regulation of gastrointestinal hormones. Results: Lcn2 deficiency significantly increased the body weight and food intake of male mice when fed ND instead of HFD, and females when fed HFD but not ND. Compared to WT male mice, adiponectin level and phosphorylated form of AMPK in hypothalamus were both increased in ND-fed Lcn2-/- male mice, but decreased in HFD-fed Lcn2-/- male mice. However, in female mice, adiponectin and its energy metabolism pathway were not altered. Instead, estradiol was found to be substantially higher in ND-fed Lcn2-/- female mice and substantially lower in HFD-fed Lcn2-/- female mice compared with WT female mice. Estradiol alteration also caused similar changes in ERα in the hypothalamus, leading to changes in PI3K/AKT energy metabolism pathway. It suggested that the increased appetite caused by Lcn2 deficiency in male mice may be due to increased adiponectin expression and promotion of AMPK phosphorylation, while in female may be related to the decrease of circulating E2 and the inhibition of hypothalamic ERα/PI3K/AKT energy metabolism pathway. Conclusion: Lcn2 plays in a highly sex-specific manner in the regulation of appetite in young mice.
DOI: 10.6084/m9.figshare.24966219.v1
title: Supplementary Material for: Sex-specific appetite regulation of lipocalin-2 in high fat diet-induced obese mice

description: Lipocalin 2 (Lcn2) is a key factor in appetite suppression. However, the effect of Lcn2 on appetite in terms of sex differences has not been thoroughly studied. Methods: Young (3-month-old) whole-body Lcn2 knockout (Lcn2-/-) mice, which were fed normal diet (ND) or high-fat diet (HFD) for eight-weeks to investigate obesity, food intake, serum metabolism, hepatic lipid metabolism, and regulation of gastrointestinal hormones. Results: Lcn2 deficiency significantly increased the body weight and food intake of male mice when fed ND instead of HFD, and females when fed HFD but not ND. Compared to WT male mice, adiponectin level and phosphorylated form of AMPK in hypothalamus were both increased in ND-fed Lcn2-/- male mice, but decreased in HFD-fed Lcn2-/- male mice. However, in female mice, adiponectin and its energy metabolism pathway were not altered. Instead, estradiol was found to be substantially higher in ND-fed Lcn2-/- female mice and substantially lower in HFD-fed Lcn2-/- female mice compared with WT female mice. Estradiol alteration also caused similar changes in ERα in the hypothalamus, leading to changes in PI3K/AKT energy metabolism pathway. It suggested that the increased appetite caused by Lcn2 deficiency in male mice may be due to increased adiponectin expression and promotion of AMPK phosphorylation, while in female may be related to the decrease of circulating E2 and the inhibition of hypothalamic ERα/PI3K/AKT energy metabolism pathway. Conclusion: Lcn2 plays in a highly sex-specific manner in the regulation of appetite in young mice.
DOI: 10.5281/zenodo.10472715
title: scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data

description: The test data of the manuscript: scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data
DOI: 10.5281/zenodo.10472714
title: scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data

description: The test data of the manuscript: scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data
DOI: 10.6084/m9.figshare.24182487
title: <i>NOS1AP</i> genotype and clinical parameters.xlsx

description: <b>Genetic polymorphisms in</b><b><i> NOS1AP</i></b><b> affects insulin secretion in response to exenatide in Chinese patients with type 2 diabetes mellitus</b>
DOI: 10.6084/m9.figshare.24182487.v3
title: <i>NOS1AP</i> genotype and clinical parameters.xlsx

description: <b>Genetic polymorphisms in</b><b><i> NOS1AP</i></b><b> affects insulin secretion in response to exenatide in Chinese patients with type 2 diabetes mellitus</b>
DOI: 10.6084/m9.figshare.24182487.v2
title: <i>NOS1AP</i> genotype and clinical parameters.xlsx

description: <b>Genetic polymorphisms in</b><b><i> NOS1AP</i></b><b> affects insulin secretion in response to exenatide in Chinese patients with type 2 diabetes mellitus</b>
DOI: 10.5281/zenodo.10408381
title: Data behind The ALCHEMI atlas: principal component analysis reveals starburst evolution in NGC 253

description: This depository is for additional files of the PCA paper using the ALCHEMI survey.

std_datalist.csv: This is a csv file that includes standardized intensities for all the transitions/continua.

pca_alchemi_corrmatrix.py: This is a python file to plot a correlation matrix of standardized intensities. It displays a transition pair when you hover the cursor on the matrix element. It uses std_datalist.csv.
DOI: 10.5281/zenodo.10408380
title: Data behind The ALCHEMI atlas: principal component analysis reveals starburst evolution in NGC 253

description: This depository is for additional files of the PCA paper using the ALCHEMI survey.

std_datalist.csv: This is a csv file that includes standardized intensities for all the transitions/continua.

pca_alchemi_corrmatrix.py: This is a python file to plot a correlation matrix of standardized intensities. It displays a transition pair when you hover the cursor on the matrix element. It uses std_datalist.csv.
DOI: 10.5281/zenodo.10458971
title: Input parameters and output trajectory files for manuscript "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"

description: Input parameters used for molecular dynamics simulations on GROMACS 2022 software and the output trajectory files for calculating binding free energy, in the manuscript with the title: "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"
description: This research project was supported by Fundamental Fund 2024, Chiang Mai University, and the National Research Council of Thailand (NRCT) (grant numbers N35A650136 for PM and N41A650086 for NK)
DOI: 10.5281/zenodo.10472764
title: Input parameters and output trajectory files for manuscript "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"

description: Input parameters used for molecular dynamics simulations on GROMACS 2022 software and the output trajectory files for calculating binding free energy, in the manuscript with the title: "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"
description: This research project was supported by Fundamental Fund 2024, Chiang Mai University, and the National Research Council of Thailand (NRCT) (grant numbers N35A650136 for PM and N41A650086 for NK)
DOI: 10.5281/zenodo.8175794
title: Input parameters and output trajectory files for manuscript "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"

description: Input parameters used for molecular dynamics simulations on GROMACS 2022 software and the output trajectory files for calculating binding free energy, in the manuscript with the title: "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"
description: This research project was supported by Fundamental Fund 2024, Chiang Mai University, and the National Research Council of Thailand (NRCT) (grant numbers N35A650136 for PM and N41A650086 for NK)
DOI: 10.5281/zenodo.8175795
title: Input parameters and output trajectory files for manuscript "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLPro: Insights from the Computational and Experimental Investigations"

description: Input parameters used for molecular dynamics simulations on GROMACS 2022 software and the output trajectory files for calculating binding free energy, in the manuscript with the title: "Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL<sup>Pro</sup>: Insights from the Computational and Experimental Investigations"
description: This research project was supported by the National Research Council of Thailand (NRCT) (grant numbers N35A650136 for PM and N41A650086 for NK), and Fundamental Fund 2023 (grant number FF66/010 for PM).
DOI: 10.6084/m9.figshare.24901782
title: Genomic attributes of airway commensal bacteria

description: https://www.biorxiv.org/content/10.1101/2022.09.08.507073v1<br>Lung diseases due to infection and dysbiosis affect hundreds of millions of people world-wide<sup>1</sup><sup>-</sup><sup>4</sup>. Microbial communities at the airway mucosal barrier are conserved and highly ordered<sup>5</sup>, reflecting symbiosis and co-evolution with human host factors<sup>6</sup>. Freed of selection to digest nutrients for the host, the airway microbiome underpins cognate management of mucosal immunity and pathogen resistance. We show here the results of the first systematic culture and whole-genome sequencing of the principal airway bacterial species, identifying abundant novel organisms within the genera <i>Streptococcus, Pauljensenia, Neisseria</i> and <i>Gemella</i>. Bacterial genomes were enriched for genes encoding antimicrobial synthesis, adhesion and biofilm formation, immune modulation, iron utilisation, nitrous oxide (NO) metabolism and sphingolipid signalling. RNA-targeting CRISPR elements in some taxa suggest the potential to prevent or treat specific viral infections. Homologues of human <i>RO60</i> present in <i>Neisseria</i> spp. provide a possible respiratory primer for autoimmunity in systemic lupus erythematosus (SLE) and Sjögren syndrome. We interpret the structure and biogeography of airway microbial communities from clinical surveys in the context of whole-genome content, identifying features of airway dysbiosis that may presage breakdown of homeostasis during acute attacks of asthma and chronic obstructive pulmonary disease (COPD). We match the gene content of isolates to human transcripts and metabolites expressed late in airway epithelial differentiation, identifying pathways that can sustain host interactions with the microbiota. Our results provide a systematic basis for decrypting interactions between commensals, pathogens, and mucosal immunity in lung diseases of global significance.
DOI: 10.6084/m9.figshare.24901782.v2
title: Genomic attributes of airway commensal bacteria

description: https://www.biorxiv.org/content/10.1101/2022.09.08.507073v1<br>Lung diseases due to infection and dysbiosis affect hundreds of millions of people world-wide<sup>1</sup><sup>-</sup><sup>4</sup>. Microbial communities at the airway mucosal barrier are conserved and highly ordered<sup>5</sup>, reflecting symbiosis and co-evolution with human host factors<sup>6</sup>. Freed of selection to digest nutrients for the host, the airway microbiome underpins cognate management of mucosal immunity and pathogen resistance. We show here the results of the first systematic culture and whole-genome sequencing of the principal airway bacterial species, identifying abundant novel organisms within the genera <i>Streptococcus, Pauljensenia, Neisseria</i> and <i>Gemella</i>. Bacterial genomes were enriched for genes encoding antimicrobial synthesis, adhesion and biofilm formation, immune modulation, iron utilisation, nitrous oxide (NO) metabolism and sphingolipid signalling. RNA-targeting CRISPR elements in some taxa suggest the potential to prevent or treat specific viral infections. Homologues of human <i>RO60</i> present in <i>Neisseria</i> spp. provide a possible respiratory primer for autoimmunity in systemic lupus erythematosus (SLE) and Sjögren syndrome. We interpret the structure and biogeography of airway microbial communities from clinical surveys in the context of whole-genome content, identifying features of airway dysbiosis that may presage breakdown of homeostasis during acute attacks of asthma and chronic obstructive pulmonary disease (COPD). We match the gene content of isolates to human transcripts and metabolites expressed late in airway epithelial differentiation, identifying pathways that can sustain host interactions with the microbiota. Our results provide a systematic basis for decrypting interactions between commensals, pathogens, and mucosal immunity in lung diseases of global significance.