cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3886/e239302
title: β-defensin-1 regulates influenza virus infection in human bronchial epithelial cells through the STAT3 signaling pathway

description: Understanding the host response to influenza A virus (IAV) infection is vital for developing intervention strategies. The primary barriers for invading respiratory pathogens are the airway epithelial cells of the respiratory tract and antimicrobial peptides produced by these cells. The antimicrobial peptide, β-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. Significant downregulation of β-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. HBEpCs overexpressing DEFB1 caused a significant reduction in IAV, that was confirmed by IAV matrix gene analysis and confocal microscopy. DEFB1expression after transfection with hsa-miR-186-5p and hsa-miR-340-5p provided evidence that DEFB1 expression could be modulated by these two miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. Overexpression of DEFB1 in IAV infected HBEpCs led to increased NF-kB expression. In a Polymerase Chain Reaction (PCR) array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of STAT3. In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered by cells overexpressing DEFB1, suggesting that this may be one of the pathways by which defensin regulates IAV replication in HBEpCs. In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that β-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239302v1
title: β-defensin-1 regulates influenza virus infection in human bronchial epithelial cells through the STAT3 signaling pathway

description: Understanding the host response to influenza A virus (IAV) infection is vital for developing intervention strategies. The primary barriers for invading respiratory pathogens are the airway epithelial cells of the respiratory tract and antimicrobial peptides produced by these cells. The antimicrobial peptide, β-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. Significant downregulation of β-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. HBEpCs overexpressing DEFB1 caused a significant reduction in IAV, that was confirmed by IAV matrix gene analysis and confocal microscopy. DEFB1expression after transfection with hsa-miR-186-5p and hsa-miR-340-5p provided evidence that DEFB1 expression could be modulated by these two miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. Overexpression of DEFB1 in IAV infected HBEpCs led to increased NF-kB expression. In a Polymerase Chain Reaction (PCR) array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of STAT3. In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered by cells overexpressing DEFB1, suggesting that this may be one of the pathways by which defensin regulates IAV replication in HBEpCs. In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that β-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239303
title: Applied force alters sensorineural and peripheral vascular function in an animal model of hand-arm vibration syndrome

description: Working with vibrating hand tools is associated with the development of hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms, finger blanching and changes in sensory function. Vibration plays a major role in the development of the symptoms that are characteristic of HAVS, however, the hands and fingers of worker using tools are also exposed to pressure applied as the workers grip tools. The pressure applied by gripping a tool might also affect blood flow and sensorineural function. Therefore, this study examined the effects of applied pressure [2 and 4 newtons (N)] on peripheral vascular and sensorineural function using a characterized rat tail model. The tails of rats were exposed to 0, 2 or 4N of applied force for 10 days. Blood flow (laser doppler) and sensitivity of the tail to pressure (Randall-Selitto pressure test) was measured on days 1, 5 and 10 of the exposure. The sensitivity of the tail nerves to electrical stimulation was measured on days 2 and 9.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239303v1
title: Applied force alters sensorineural and peripheral vascular function in an animal model of hand-arm vibration syndrome

description: Working with vibrating hand tools is associated with the development of hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms, finger blanching and changes in sensory function. Vibration plays a major role in the development of the symptoms that are characteristic of HAVS, however, the hands and fingers of worker using tools are also exposed to pressure applied as the workers grip tools. The pressure applied by gripping a tool might also affect blood flow and sensorineural function. Therefore, this study examined the effects of applied pressure [2 and 4 newtons (N)] on peripheral vascular and sensorineural function using a characterized rat tail model. The tails of rats were exposed to 0, 2 or 4N of applied force for 10 days. Blood flow (laser doppler) and sensitivity of the tail to pressure (Randall-Selitto pressure test) was measured on days 1, 5 and 10 of the exposure. The sensitivity of the tail nerves to electrical stimulation was measured on days 2 and 9.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239304
title: Factors affecting chlorinated product formation from sodium hypochlorite bleach and limonene reactions in the gas phase

description: The application of sodium hypochlorite bleach to surfaces causes the release of chlorine (Cl2) and hypochlorous acid (HOCl) into the gas phase where reactions with organic compounds can occur. The purpose of the current study was to investigate the reaction products generated from gas-phase bleach oxidants and limonene, a fragrance compound commonly found in indoor air due to personal care products and cleaning products. Gas-phase reactions were prepared in Teflon chambers housing HOCl, Cl2, and limonene. The resulting chemical products were collected and analyzed using gas-phase preconcentration following by gas chromatography and high-resolution mass spectrometry. Several chlorinated products were detected including a limonene chlorohydrin and limonene species containing one, two, and three chlorines. Product concentration and yields were estimated for the most abundant products, and greater than 80% of the transformed limonene was represented in the detected products. Temporal sampling of the reactions allowed time courses to be plotted for limonene transformation and chlorinated limonene product generation under different conditions including the treatments of HOCl/Cl2, Cl2 only, high vs. low relative humidity, and +/- ozone. These experiments provide additional insight into the chemical transformations initiated by sodium hypochlorite bleach oxidants in the gas phase which may be of interest to human health.
description: downloaded 10/28/2025
DOI: 10.3886/e239304v1
title: Factors affecting chlorinated product formation from sodium hypochlorite bleach and limonene reactions in the gas phase

description: The application of sodium hypochlorite bleach to surfaces causes the release of chlorine (Cl2) and hypochlorous acid (HOCl) into the gas phase where reactions with organic compounds can occur. The purpose of the current study was to investigate the reaction products generated from gas-phase bleach oxidants and limonene, a fragrance compound commonly found in indoor air due to personal care products and cleaning products. Gas-phase reactions were prepared in Teflon chambers housing HOCl, Cl2, and limonene. The resulting chemical products were collected and analyzed using gas-phase preconcentration following by gas chromatography and high-resolution mass spectrometry. Several chlorinated products were detected including a limonene chlorohydrin and limonene species containing one, two, and three chlorines. Product concentration and yields were estimated for the most abundant products, and greater than 80% of the transformed limonene was represented in the detected products. Temporal sampling of the reactions allowed time courses to be plotted for limonene transformation and chlorinated limonene product generation under different conditions including the treatments of HOCl/Cl2, Cl2 only, high vs. low relative humidity, and +/- ozone. These experiments provide additional insight into the chemical transformations initiated by sodium hypochlorite bleach oxidants in the gas phase which may be of interest to human health.
description: downloaded 10/28/2025
DOI: 10.3886/e239305
title: Testing the shock protection performance of Type I construction helmets using impactors of different masses

description: Top impacts are considered essential tests to evaluate the shock absorption performance of commonly used type I industrial helmets. Currently, there are two major test standards that are widely applied in helmet industry: ANSI/ISEA Z89.1 and EN397. Since drop impacts are performed using different impactors and at drop heights, results obtained using different test standards are not directly comparable. The purpose of the current study is to evaluate and compare the helmet impact test results obtained using these two frequently used helmet test standards. A representative basic Type I construction helmet model was selected for the study. A total of 19 drop impact tests were performed at different drop heights and with two different impactors (3.6 kg and 5.0 kg). Group (a) contains 10 drop impacts performed using the 3.6 kg impactor at drop heights from 0.31 m to 1.93 m. Group (b) contains 9 drop impacts performed using the 5.0 kg impactor at drop heights from 0.22 m to 1.32 m. Each of the impact trials was replicated four times. Relationships between the peak impact force and the drop height for these two test groups were analyzed and compared. When the helmets were tested with potential impact energy smaller than critical values, a consistent trend for the relationship of peak impact force as a function of the potential impact energy was obtained. Our results show that our previously proposed quantitative evaluation approach for industrial helmets’ shock absorption performance can be used with either the ANSI/ISEA Z89.1 or EN395 standard to quantify industrial helmets’ shock absorption performance. Furthermore, our results illustrated that the peak impact force would not be a reliable parameter to evaluate the helmets’ safety margin.
description: Data downloaded 5/20/2025
DOI: 10.15468/dl.8xsjsx
title: Occurrence Download

description: A dataset containing 2434 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eupherusa cyanophrys"
 ]
}

 The dataset includes 2434 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005466-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e239305v1
title: Testing the shock protection performance of Type I construction helmets using impactors of different masses

description: Top impacts are considered essential tests to evaluate the shock absorption performance of commonly used type I industrial helmets. Currently, there are two major test standards that are widely applied in helmet industry: ANSI/ISEA Z89.1 and EN397. Since drop impacts are performed using different impactors and at drop heights, results obtained using different test standards are not directly comparable. The purpose of the current study is to evaluate and compare the helmet impact test results obtained using these two frequently used helmet test standards. A representative basic Type I construction helmet model was selected for the study. A total of 19 drop impact tests were performed at different drop heights and with two different impactors (3.6 kg and 5.0 kg). Group (a) contains 10 drop impacts performed using the 3.6 kg impactor at drop heights from 0.31 m to 1.93 m. Group (b) contains 9 drop impacts performed using the 5.0 kg impactor at drop heights from 0.22 m to 1.32 m. Each of the impact trials was replicated four times. Relationships between the peak impact force and the drop height for these two test groups were analyzed and compared. When the helmets were tested with potential impact energy smaller than critical values, a consistent trend for the relationship of peak impact force as a function of the potential impact energy was obtained. Our results show that our previously proposed quantitative evaluation approach for industrial helmets’ shock absorption performance can be used with either the ANSI/ISEA Z89.1 or EN395 standard to quantify industrial helmets’ shock absorption performance. Furthermore, our results illustrated that the peak impact force would not be a reliable parameter to evaluate the helmets’ safety margin.
description: Data downloaded 5/20/2025
DOI: 10.15468/dl.uc9ehj
title: Occurrence Download

description: A dataset containing 256 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "PublishingCountry is Colombia",
 {
 "and" : [
 "Country is Colombia",
 {
 "not" : {
 "Issue" : [
 "is Country coordinate mismatch"
 ]
 }
 }
 ]
 }
 ]
 },
 {
 "and" : [
 "TaxonKey is one of (Squamata [GBIF Backbone Taxonomy], Testudines [GBIF Backbone Taxonomy], Cocodrylidae [GBIF Backbone Taxonomy])",
 "GadmGid is one of (COL.10.1_2)",
 {
 "or" : [
 {
 "and" : [
 "Elevation is greater than or equal to 600m"
 ]
 },
 {
 "and" : [
 "Elevation is less than or equal to 1500m"
 ]
 }
 ]
 },
 {
 "and" : [
 "Year is greater than or equal to 2015"
 ]
 }
 ]
 }
 ]
}

 The dataset includes 256 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005467-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qtg2cs
title: Occurrence Download

description: A dataset containing 136 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microtus umbrosus"
 ]
}

 The dataset includes 136 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005468-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zx6hc7
title: Occurrence Download

description: A dataset containing 53 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Surirella striatula, Pseudostaurosira subsalina, Rhopalodia musculus, Discostella woltereckii, Adlafia minuscula, Achnanthes thienemannii, Nitzschia forfica, Aulacoseira ambigua, Brachysira neoexilis, Fragilaria lanceolata, Achnanthidium latecephalum, Denticula elegans)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "Issue" : [
 "is one of (Recorded date invalid, Recorded date mismatch, Recorded date unlikely, Modified date invalid)"
 ]
 }
 },
 "Geometry MULTIPOLYGON (((27.1586 -33.5889, 28.2048 -32.9007, 28.5753 -32.6569, 29.4902 -31.7517, 29.7284 -31.5933, 29.7284 -28.9003, 29.7284 -24.1503, 25.0903 -24.1503, 24.9784 -24.369, 24.9333 -24.4571, 23.8962 -24.2467, 22.8065 -24.295, 22.3719 -24.7207, 22.2323 -25.547, 22.0387 -25.7188, 21.7833 -25.7784, 21.5388 -25.7113, 21.3553 -25.5415, 20.7576 -24.3688, 20.5896 -24.1503, 20.529 -24.0715, 20.509 -24.0455, 20.2284 -23.6805, 20.0952 -23.5072, 19.9968 -23.017, 19.7843 -22.5405, 19.1988 -21.8785, 18.5972 -21.5447, 17.8859 -21.3993, 17.1626 -21.4805, 16.5332 -21.7596, 16.1257 -22.0882, 15.8234 -22.4662, 15.606 -22.8993, 15.4784 -23.4046, 15.4933 -24.0715, 15.4945 -24.1257, 15.5034 -24.1503, 16.0509 -25.6631, 15.6372 -28.0032, 16.2782 -28.5786, 16.4358 -28.7202, 16.5654 -28.9003, 16.726 -29.1235, 17.1957 -30.3752, 17.6655 -31.1743, 18.1322 -31.7679, 18.2495 -32.2638, 18.2339 -32.5266, 18.1411 -32.657, 18.1007 -32.7021, 18.0224 -32.6366, 17.8923 -32.6419, 17.754 -32.8255, 17.7723 -32.9007, 17.8156 -33.0786, 18.0371 -33.4611, 18.1771 -33.6503, 18.2971 -33.8124, 18.2181 -34.0492, 18.3197 -34.3408, 18.4452 -34.429, 18.5435 -34.4213, 18.5872 -34.3667, 18.5363 -34.167, 18.7345 -34.1508, 18.7216 -34.3637, 18.7808 -34.4521, 19.0289 -34.4206, 19.0831 -34.4835, 19.2655 -34.5017, 19.2032 -34.6157, 19.2394 -34.6926, 19.375 -34.6963, 19.6091 -34.8524, 19.8251 -34.8396, 19.9798 -34.9064, 20.1081 -34.8731, 20.1517 -34.7847, 20.2284 -34.7667, 20.2855 -34.7533, 20.509 -34.5676, 20.524 -34.555, 20.8859 -34.5419, 20.9606 -34.4398, 21.2995 -34.5131, 21.5296 -34.4338, 21.8696 -34.4439, 22.0323 -34.2835, 22.221 -34.2428, 22.2566 -34.1304, 22.5993 -34.0741, 22.9652 -34.1674, 23.4069 -34.1858, 23.4955 -34.0792, 23.6056 -34.0563, 24.8471 -34.2877, 24.9447 -34.2397, 24.9784 -34.1564, 24.9784 -33.6503, 26.9976 -33.6503, 27.1586 -33.5889)))"
 ]
}

 The dataset includes 53 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57931/2497839
title: IM3 Projected U.S. Western Interconnection Grid Stress Dataset

description: This dataset provides projected grid stress and reliability results (including all model inputs and outputs from GO WEST and TEP) for Integrated Multisector, Multiscale Modeling (IM3) Phase 2 simulations across eight different scenarios for the U.S. Western Interconnection through 2055. The scenarios include combinations of two Shared Socioeconomic Pathways (SSP3 and SSP5) with four high-resolution climate projections specific to the United States from a set of Thermodynamic Global Warming (TGW) simulations. These climate projections include "hotter" and "cooler" variants for two Representative Concentration Pathways (RCP4.5 and RCP8.5). The resulting eight simulations are:

rcp45cooler_ssp3
rcp45cooler_ssp5
rcp45hotter_ssp3
rcp45hotter_ssp5
rcp85cooler_ssp3
rcp85cooler_ssp5
rcp85hotter_ssp3
rcp85hotter_ssp5
GO WEST is an open-source power grid modeling framework for the U.S. Western Interconnection, which allows users to tailor the model depending on their research study and science questions. It covers 28 balancing authorities (BAs) and 12 states in U.S. Western Interconnection. GO WEST allows users to select different number of nodes and come up with a simplified network by utilizing 10,000 nodal topology of the U.S. Western Interconnection (ACTIVSg10k). Users can select different number of nodes, mathematical formulations (linear programming vs. mixed-integer linear programming), transmission line limit scaling factors, and hurdle rate scaling factors. GO WEST offers a unit commitment and economic dispatch (UC/ED) module to simulate grid operations on an hourly scale. In this sense, users can calibrate and validate their model versions by comparing model outputs to historical datasets. 
TEP is an open-source transmission capacity expansion model, built on the GO WEST framework. It utilizes linear programming to optimize transmission capacity addition investment on existing lines within the GO WEST framework. The TEP model only increases the thermal capacity of existing transmission lines and does not add new lines to the system, which leaves the topology preserved. In order to use TEP model, users need to create scenarios with the GO WEST framework. 
Please refer to README file for a detailed description of the dataset including individual files and references.
DOI: 10.3886/e239306
title: Optimization of Aspergillus versicolor culture and aerosolization in a murine model of inhalational fungal exposure

description: Aspergillus versicolor is ubiquitous in the environment and is particularly abundant in damp indoor spaces. Exposure to Aspergillus species, as well as other environmental fungi, has been linked to adverse health outcomes including asthma, allergy, and even local or disseminated infection. However, the pulmonary immunological mechanisms associated with repeated exposure to A. versicolor have remained relatively uncharacterized. Here, A. versicolor was cultured and desiccated on rice, then placed in an acoustical generator system to achieve aerosolization. Mice were challenged with titrated doses of aerosolized conidia to examine deposition, lymphoproliferative properties, and then the immunotoxicological response to repeated inhalation exposures. The necessary dose to induce lymphoproliferation, but not infection-like pathology, was identified. Further, it was determined that the dose was able to initiate localized immune responses. The data presented in this study demonstrate an optimized and reproducible method for delivering A. versicolor conidia to rodents via nose-only inhalation. Additionally, the feasibility of a long-term repeated exposure study was established. This experimental protocol can be used in future studies to investigate physiological effects of repeated pulmonary exposure to fungal conidia utilizing a practical and relevant mode of delivery. In total, these data constitute an important foundation for subsequent research in the field.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239306v1
title: Optimization of Aspergillus versicolor culture and aerosolization in a murine model of inhalational fungal exposure

description: Aspergillus versicolor is ubiquitous in the environment and is particularly abundant in damp indoor spaces. Exposure to Aspergillus species, as well as other environmental fungi, has been linked to adverse health outcomes including asthma, allergy, and even local or disseminated infection. However, the pulmonary immunological mechanisms associated with repeated exposure to A. versicolor have remained relatively uncharacterized. Here, A. versicolor was cultured and desiccated on rice, then placed in an acoustical generator system to achieve aerosolization. Mice were challenged with titrated doses of aerosolized conidia to examine deposition, lymphoproliferative properties, and then the immunotoxicological response to repeated inhalation exposures. The necessary dose to induce lymphoproliferation, but not infection-like pathology, was identified. Further, it was determined that the dose was able to initiate localized immune responses. The data presented in this study demonstrate an optimized and reproducible method for delivering A. versicolor conidia to rodents via nose-only inhalation. Additionally, the feasibility of a long-term repeated exposure study was established. This experimental protocol can be used in future studies to investigate physiological effects of repeated pulmonary exposure to fungal conidia utilizing a practical and relevant mode of delivery. In total, these data constitute an important foundation for subsequent research in the field.
description: Data downloaded 5/20/2025