cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/3dw92rdgwz
title: Raw data-Assessment of DCE Utility for PCa Diagnosis Using PI-RADS v2.1: Effects on Diagnostic Accuracy and Reproducibility

description: research data of the work
DOI: 10.17632/4csjbf5hzy
title: LINF_180018500

description: Cysteine proteinase; Leishmania infantum (strain JPCM5)
DOI: 10.17632/6kz2rv4g6j
title: LCPT vs MR-4

description: Comparison of two once-daily administered tacrolimus formulations.
DOI: 10.17632/cd988kkyn6
title: tRNA m1A Methylation Regulates Ergosterol Biosynthesis for Infection of Magnaporthe oryzae

description: Uncropped blots, including Western and Northern blots;
Uncropped phenotypes, including phenotypes of Magnaporthe oryzae.
DOI: 10.17632/g3ppf76mfn
title: literature in industry 40

description: lit i40
DOI: 10.17632/hdhdryf7ct
title: Antisense oligonucleotide targeting macrophage migration inhibitory factor ameliorates experimental autoimmune encephalomyelitis

description: The file contains values underlying all graphs in figures and behind any reported means for the article titled "Antisense oligonucleotide targeting macrophage migration inhibitory factor ameliorates experimental autoimmune encephalomyelitis."

The cover and abstract of article is as follows:
Antisense oligonucleotide targeting macrophage migration inhibitory factor ameliorates experimental autoimmune encephalomyelitis

Benyuan Zhang1, 2, Sang-Hyeon Ju3, Minsung Park3, Min Hee Lee4, Hyun Jung Hong3, Jung Tae Kim3, Dong Yun Lee3, Jaehun Kim3, Ju Hee Lee1, 2, 5, Jiebo Zhu2, Jun Young Heo2, Yunju Jo6, Dongryeol Ryu6, Jinkuk Kim3, Hyon-Seung Yi1, 2, 5,**, Minho Shong3, 4, 7*

1Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea
2Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea
3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
4THOR Therapeutics, Inc., Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
5Department of Internal Medicine, Chungnam National University Hospital, Daejeon 35015, Republic of Korea
6Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
7Lead contact

SUMMARY
Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system (CNS), characterized by demyelination and axonal damage. This research investigates the role of macrophage migration inhibitory factor (MIF) in MS pathogenesis, focusing on the development and therapeutic potential of antisense oligonucleotides (ASOs) targeting MIF. Transcriptomic analysis of MS patients highlighted increased expression of MIF and its receptor CD74 in CNS lesions. In response, MIF-specific ASOs were designed and shown to effectively reduce MIF levels in vitro and in vivo. The study utilized the experimental autoimmune encephalomyelitis (EAE) mouse model, where intracerebroventricular administration of these ASOs led to significant reductions in demyelination and immune cell infiltration, while also improving motor functions. These findings suggest that targeting MIF with ASOs could be a viable treatment strategy for reducing both inflammation and neurodegeneration in MS.

Keywords: Macrophage migration inhibitory factor, antisense oligonucleotide, experimental autoimmune encephalomyelitis, multiple sclerosis, CNS inflammation
DOI: 10.17632/kxrph5sz9k
title: Growth Mindset, Cognitive Fusion, Information Bias

description: The study aimed to investigate the relationships between growth mindset, cognitive fusion, negative information bias, and positive information bias. The Growth Mindset Scale, the Attention to Positive and Negative Information Scale, and the Cognitive Fusion Questionnaire were employed. A total of 470 college students in China participated in the study. The findings showed a negative correlation between a growth mindset and cognitive fusion, revealing that a higher Growth Mindset Scale score predicted a lower level of cognitive fusion. In addition, a parallel mediation analysis demonstrated that negative information bias mediated the relationship between a growth mindset and cognitive fusion and that the indirect effect was significant. However, the mediation of positive information bias in this model was not significant. These results suggest that possessing a growth mindset is advantageous for mental health.
DOI: 10.17632/x4x92rx3tj
title: Young children's learning from storybooks varied by interactive and multimedia features

description: Young children's learning from storybooks varied by interactive and multimedia features
DOI: 10.17632/xbsz777x3t
title: LDHU3_01.0640

description: hypothetical protein - conserved; Leishmania donovani
DOI: 10.17632/xtr6kvy5dn
title: In Situ Trace Element and Nd Isotope Analyses of Apatite in Granitoids From the Eastern Central Asian Orogenic Belt: Implications for Petrogenesis and Post-Magmatic Alteration

description: Tables S1-S7
DOI: 10.17632/ygw5g544mn
title: Reference list for the KAKENHI proposal 202108

description: This is a reference list for the research funding proposal that is to be submitted to the JSPS KAKENHI: Grant-in-Aid for Early-Career Scientists.
DOI: 10.17632/znryjb62y3
title: Stress-induced transcriptional readthrough into neighboring genes is linked to intron retention | Figure 1E

description: Raw imaging data from Figure 1E from the article.
Lanes, in order of left to right, top to bottom:

FIRST ROW:
Furin-Fes (cDNA, Osmotic stress, 2h)
Furin-Fes (cDNA, Osmotic stress, 2h)
Furin-Fes (cDNA, Control)
Furin-Fes (cDNA, Control)
Furin-Fes (no-RT, Osmotic stress, 2h)
Furin-Fes (no-RT, Osmotic stress, 2h)
Furin-Fes (no-RT, Control)
Furin-Fes (no-RT, Control)
Ladder
Nectin2-Tomm40 (cDNA, Osmotic stress, 2h)
Nectin2-Tomm40 (cDNA, Osmotic stress, 2h)
Ladder
Tmem62-Ccndbp1 (cDNA, Osmotic stress, 2h)
Tmem62-Ccndbp1 (cDNA, Osmotic stress, 2h)
Tmem62-Ccndbp1 (cDNA, Control)
Tmem62-Ccndbp1 (cDNA, Control)
Ladder

SECOND ROW:
Nectin2-Tomm40 (cDNA, Control)
Nectin2-Tomm40 (cDNA, Control)
Ladder
Tnfrsf12a-Thoc6 (cDNA, Osmotic stress, 2h)
Tnfrsf12a-Thoc6 (cDNA, Osmotic stress, 2h)
Tnfrsf12a-Thoc6 (cDNA, Control)
Tnfrsf12a-Thoc6 (cDNA, Control)
Tnfrsf12a-Thoc6 (no-RT, Osmotic stress, 2h)
Tnfrsf12a-Thoc6 (no-RT, Osmotic stress, 2h)
Tnfrsf12a-Thoc6 (no-RT, Control)
Tnfrsf12a-Thoc6 (no-RT, Control)
DOI: 10.17632/4smjmzn5mg
title: algorithm_degradation_slb

description: This algorithm includes the MATLAB file used for the calculations in the paper titled "Technical and Economic Assessments in Customized Cost Analysis for Second-Life Batteries."
DOI: 10.17632/97vpwtjbhh
title: LINF_280025800

description: Zinc transporter 3 | ZIP3B
Leishmania infantum (strain JPCM5)
DOI: 10.17632/bfk24tk6zn
title: Effect of prolonged standing on knee pain among Physiotherapy Professionals: An online cross-sectional study

description: Extended standing has been demonstrated to have adverse
health effects on the lower limb. This study aims to determine the effect of prolonged
standing on knee pain among Physiotherapy Professionals.
DOI: 10.17632/f36szwkwjj
title: The history and mechanism of southeastward extrusion and exhumation of the Tibetan Plateau lithosphere

description: This dataset includes the following content. Figure S1. The granitic samples along the Gaoligong shear zone in the Nujiang tectonic zone. Figure S2. Undeformed samples from the Lushui, Gongshan, and Bingzhongluo regions in the Nujiang tectonic zone. Figure S3. Apatite fission-track radial plots of study samples using Radial Plotter. Figure S4. AHe ages versus effective uranium content [eU] and equivalent sphere radius for samples from the Nujiang tectonic zone. Figure S5. The comparison of the observed ages and predicted ages by the best-fit model in this paper. Figure S6. The 45−40 Ma mafic dykes were distributed in the Nujiang tectonic zone. Figure S7. The 45−40 Ma deformed rocks were distributed in the whole SE Tibetan Plateau. Table S1. Results for samples mica 40Ar/39Ar thermochronology. Table S2. Results for samples zircon U-Pb, apatite (U‐Th)/He, and fission track thermochronology. Table S3. Results for single-grain apatite (U‐Th)/He thermochronology. Table S4. Results for standard MK-1 and Durango apatite (U-Th)/He thermochronology. Table S5. Results for single-grain apatite fission track thermochronology. Table S6. The fission track length data for sample 20TC-05. Table S7. 40Ar/39Ar geochronological data for each sample. Table S8. LA-ICP-MS zircon U-Pb isotopic analyses of the samples in the Dawangtang (Nujiang turn) region.
DOI: 10.17632/vstnv3vdns
title: Índice de Similaridade

description: Índice de similaridade técnica entre as ocupações da CBO - Classificação Brasileira de Ocupações
DOI: 10.17632/w23rzzhsm4
title: LINF_150008200

description: ribonucleoprotein p18, mitochondrial precursor Leishmania infantum (strain JPCM5)
DOI: 10.17632/2hhv573mjn
title: Are we seeing eye to eye_dataset_2023

description: This study set out to improve understanding of how shoppers translate their retail companions’ attributes and actions into positive or negative emotional responses and shopping behavior. The latter was measured in terms of whether or not shoppers tended to end their purchase decision rather quickly due to a sense of 'haste' and whether or not shoppers were more likely to abandon their purchase. Data collected online from 316 respondents in Germany by means of a questionnaire with accompanying scenarios delivered three important insights. First, shoppers' sense of haste is influenced by whether the shopping companion is ‘enthusiastic’, ‘expert’ or ‘apathetic’. Second, emotions play a crucial role in determining shoppers’ behavior, even before consideration of the input of a companion. Third, shoppers’ emotions exert a critical influence on their perception of haste and also on the likelihood of their abandoning the purchase, while fully mediating a companion’s influence on abandonment. From a theoretical perspective, our findings offer interesting future research avenues with regard to the effect of shopper-companion interplay on shopping behavior and shoppers’ perceptions of the overall shopping experience. 

The dataset is to be interpreted as follows:

- The type of companion indicates which scenario the respective respondent was involved in, i.e. the type of companion they were confronted with or whether they read the unaccompanied control group scenario.
- Emotions measurement was derived from: Byun, S.-E., & Mann, M. (2011). The influence of others: The impact of perceived human crowding on perceived competition, emotions, and hedonic shopping value. Clothing and Textiles Research Journal, 29(4), 284-297. doi:10.1177/0887302x11422820
- Emotions and haste were measured with 7-point Likert scales ranging from 1 (strongly disagree) to 7 (strongly agree)
- Abandonment was measured by one question that required participants to indicate whether they would either proceed with the purchase decision or aborting the shopping trip after having read the scenario description

The respective questions/statements read as follows:

Haste 
•	I would take my time to make a decision.
•	I would hurry up making a decision.
•	I would calmly ponder all my options.
•	I would try to come to a decision as quickly as possible.

Abandonment
Based on the situation described before, how would you most likely proceed?
•	I would dedicate myself to the product selection
or
•	“I would postpone my decision”
DOI: 10.17632/75jnyk3v4b
title: LINF_220007400

description: phosphoinositide phosphatase | DUSP1
Leishmania infantum (strain JPCM5)
DOI: 10.17632/jc8k4cnr2c
title: tf-idf metric iKeyCriteria (dataset)

description: Result of document analysis with the tf-idf metric to obtain a key criteria pattern in serious game design methodologies.
DOI: 10.17632/xv5jwz3hhv
title: TCF7L2 dataset

description: TCF7L2 SNPs dataset
DOI: 10.17632/cs6x4f86f2
title: Data on heparinised poloxamer hydrogel with hyaluronic acid can stabilise and sustain the release of bioactive NT-3

description: This experimental dataset explores the utilisation of heparinized poloxamer hydrogel, blended with hyaluronic acid, for the delivery of neurotrophin-3 (NT-3).
DOI: 10.17632/ftf8jvyw7v
title: LINF_020006900

description: phosphoglycan beta 1-3 galactosyltransferase
DOI: 10.17632/w54zw47gkw
title: Development of probiotic yogurt products incorporated with Lactobacillus kefiranofaciens OSU-BSGOA1 in mono- and coculture with Kluyveromyces marxianus

description: Supplemental material
DOI: 10.17632/ysv6f9srp5
title: Salinity rather than nutrients reduces alien plant abundance and sustain native diversity in coastal dunes

description: Biological invasion is recognized as one of the major threats to biodiversity, particularly in coastal dune ecosystems. Many studies have associated alien plant invasion of dune ecosystem to human disturbances, but less is known about the role of soil properties in invasion after disturbance. Soil properties exert a particular role at early stages of succession, where changes in the initial species composition might shape the final success of the invaders. The aim of this study is to understand if it is possible to curb alien species success on highly invaded dunes by manipulating soil properties.
In a barrier island of the Marano and Grado’s lagoon, Northern Adriatic Sea, we mechanically removed all the vegetation present in the back dune, triggering a new ecological succession and further altered soil properties by salt, nitrogen, and organic matter addition in a full factorial design with randomized blocks. Soil disturbance reduced the overall diversity and abundance of alien plants. Soil treatment interactions strongly shaped total plant species abundance, diversity and composition. Soil salinity had a positive effect on native species abundance while decreasing the overall number of alien species, especially in soil with added organic matter. Our findings suggest that soil salinity, and its interplay with other soil properties, might reduce the initial alien species propagule pressure linked to soil seed bank and, hence, shape plant community trajectories. This study highlights that alien plant containment should be focused on early stages of succession.
DOI: 10.17632/2v5532nbgh
title: Tonic TCR and IL-1-beta signaling mediate phenotypic alterations of naive CD4+ T cells

description: Inert naive CD4+ T (TN) cells differentiate into functional helper T or regulatory T (Treg) cell subsets upon encountering antigens, enabling properly-directed immune responses. Although all TN cells can differentiate into any Th and Treg cell subsets, recent studies have revealed some heterogeneity among TN cells. Here, by developing novel reporter mice that detect ongoing T cell receptor (TCR) signaling, we revealed the effects of tonic TCR signaling on TN cells, while unexpectedly finding that IL-1-beta affects TN cell characteristics. IL-1-beta signals to TN cells particularly in the spleen and in inflamed tissues, attenuating their differentiation potential to Treg cells. A mouse colitis model revealed reversible effects of IL-1-beta on TN cells' colitogenic activities. Aberrant regulation of IL-1-betatargets in TN cells was detected in colitis patients, showing its association with therapeutic response to anti-TNF therapies. Our work revealed the IL-1-beta-TN cell axis as a novel regulator of immune response.
DOI: 10.17632/5dp6hwckj5
title: JAAD-D-24-00500-SuppTable1

description: Supplemental Table 1. Comparison of wholesale acquisition (WAC) and patient costs of clascoterone and sarecycline with other acne therapies. WAC info is publicly available and represents the cost wholesaler pays to manufacturer (data collected as of April 2024). WAC is not the same as “ASP”; ASP is the price the pharmacy pays for the medication from the wholesaler. Payment adjudication happens after they dispense to the patient. Covered: the process is only pertinent to "covered" prescriptions; when a Rx goes through covered the following fees are taken out of the WAC of each prescription (amount depends on contract negotiations: rebates to PBM/insurance for a branded drug in dermatology ranges from 50% of WAC to 80% of WAC in addition to other standard fees: returns, savings cards, e-vouchers, rebates, wholesaler fees, prompt pay). Uncovered: more often than not, in dermatology, when a medication is not covered, the manufacturer bypasses the wholesaler and the only income to the manufacturer is the co-pay the patient pays minus a dispensing fee & COGs (cost of goods). Distribution = manufacturer to pharmacy; pharmacy to patient. Cash Flow = uncovered copay from patient to pharmacy, pharmacy keeps dispensing fee, remaining to manufacturer (pharma company). Prior Authorizations (PAs): the overall Rx process without submitting a PA hurts the coverage of the medication because payors do not see this volume coming through. Payors want enough volume to make it worth paying for. Not filing PAs hurts the coverage of the dermatology specialty. Without them, drug coverage will not get better and the only remaining option is to increase the list price of the drug. CoPay – information in Table came from several common specialty pharmacies; however, co-pay depends on partnerships between manufacturers and pharmacies.
a must be filled at PhilRx for $90 offer
b off label use requires prior authorization and does not guarantee coverage
DOI: 10.17632/7n2mc25mt9
title: Rivera-Urbina et al. Broca and Wernicke tDCS

description: Data set, scripts and analysis results
DOI: 10.17632/bkz6wd74mv
title: IVF and female non-esential trace elements in follicular fluid, whole blood and urine

description: IVF outcomes from fifty-one women and measures of ten non-essential trace elements (Hg, Pb, As, Ba, Sr, Rb, Cs, Sn, Ni, Co) in their follicular fluid, whole blood, and urine
DOI: 10.17632/bxkkp6bv2j
title: Mapping the invisible chromatin transactions of prophase chromosome remodelling

description: Original image data for Figures 1, 2 and 6
DOI: 10.17632/cf6t2k33mf
title: LDHU3_04.0970

description: 60S ribosomal protein L10 Leishmania donovani (HU3 strain)
DOI: 10.17632/r8trrrzkpm
title: Omalizumab in the treatment of spontaneous chronic urticaria in SUS in the state of Bahia - synthesis of evidence on efficacy, safety and simplified estimate of budgetary impact

description: To analyze and synthesize the available scientific research on the efficacy and safety of the treatment of patients with ECU, refractory antihistamines-H1, and to estimate the budgetary impact of their incorporation into SUS in Bahia. Methods: Synthesis of scientific tests, monitoring of simplified estimate of budgetary impact.
DOI: 10.17632/tj6m9v2gky
title: The clinical spectrum of COVID-19-associated cutaneous manifestations: an Italian multicenter study of 200 adult patients

description: Supplemental Figure 1. Clinical features of COVID-19-associated skin manifestations. A) Urticarial rash on the lower limbs. B) Confluent erythematous rash on the chest and abdomen. C) Papulovesicular exanthem. D) Chilblain-like acral lesions on the feet. E) Palpable purpura on the outside of the thigh. F) Livedo reticularis-like lesions on the thighs. All photographs belong to the authors’ own collections.
DOI: 10.17632/vwjnkwxx4z
title: The RGD-binding Integrins αvβ6 and αvβ8 are Receptors for Mouse Adenovirus-1 and -3 Infection

description: Mammalian AdVs comprise more than ~350 types including over 100 human adenoviruses (HAdVs) and just three mouse AdV (MAdV). While most HAdVs initiate infection by high affinity/avidity binding of their fiber knob (FK) protein to either coxsackievirus AdV receptor (CAR), CD46 or desmoglein (DSG)-2, MAdV-1 (M1) infection requires arginine-glycine-aspartate (RGD) binding integrins. To identify the receptors mediating MAdV infection we generated five novel reporter viruses for MAdV-1/-2/-3 (M1, M2, M3) transducing permissive murine (m) CMT-93 cells, but not B16 mouse melanoma cells expressing mCAR, human (h) CD46 or hDSG-2. Recombinant M1 or M3 FKs cross-blocked M1 and M3 but not M2 infections. Profiling of murine and human cells expressing RGD-binding integrins suggested that αvβ6 and αvβ8 heterodimers are associated with M1 and M3 infections. Ectopic expression of mβ6 in B16 cells strongly enhanced M1 and M3 binding, infections and progeny productions comparable with mαvβ6-positive CMT-93 cells, whereas mβ8 expressing cells were more permissive to M1 than M3. Anti-integrin antibodies potently blocked M1 and M3 binding and infections of CMT-93 cells and hαvβ8-positive M000216 cells. Soluble integrin αvβ6, and synthetic peptides containing the RGDLXXL sequence derived from FK-M1, FK-M3 and foot and mouth disease virus coat protein potently interfered with M1/M3 infections, in agreement with high affinity interactions of FK-M1/FK-M3 with αvβ6/αvβ8, determined by surface plasmon resonance measurements. Molecular docking simulations of ternary complexes revealed a bent conformation of RGDLXXL-containing FK-M3 peptides on the subunit interface of αvβ6/β8, where the distal leucine residue dips into a hydrophobic pocket of β6/8, the arginine residue ionically engages αv aspartate215, and the aspartate residue coordinates a divalent cation in αvβ6/β8. Together, the RGDLXXL-bearing FKs are part of an essential mechanism for M1/M3 infection engaging murine and human αvβ6/8 integrins, which are also highly conserved in other mammals, and thus may favour cross-species virus transmission.
DOI: 10.17632/5kpwzdmxmh
title: LINF_050014000

description: hypothetical protein - conserved; Leishmania infantum
DOI: 10.17632/6xm78dbvc8
title: LDHU3_16.1900

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/8d92n72hj3
title: Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

description: Raw experimental data
DOI: 10.17632/g5sznxfzfw
title: Non-microRNA Binding Competitively Inhibits LIN28 Regulation. Tan et al.

description: Scanned images of unmodified western blots associated with publication.
DOI: 10.17632/k94njg2m5k
title: Diseño y Construcción un Prototipo LIGHTSTICKS Personalizado y Caracterizado: Vigilancia Tecnológica

description: El III Festival de la Felicidad 2024 busca celebrar la alegría, la unión y la creatividad a través de experiencias compartidas y multisensoriales. En este contexto, los lightsticks personalizados se convertirán en una herramienta clave para potenciar la participación de los asistentes y reforzar la identidad visual del evento. Estos dispositivos, que emiten luz y pueden sincronizarse para generar efectos visuales colectivos, permitirán a los participantes interactuar de manera activa con el espectáculo, promoviendo un ambiente de cohesión y celebración.

El diseño de estos lightsticks estará inspirado en los valores del festival, como la felicidad y la energía positiva. Se utilizarán colores vibrantes y formas simbólicas que representen la esencia del evento, transmitiendo vitalidad y dinamismo. Además, se integrarán tecnologías avanzadas para sincronizar los lightsticks y crear patrones de luz coordinados, lo que contribuirá a crear espectáculos visuales únicos. El proyecto busca que estos dispositivos no solo sean estéticamente atractivos, sino también funcionales y cómodos para el uso prolongado durante el festival.

El objetivo central del proyecto es la construcción de lightsticks personalizados que reflejen visualmente la identidad del III Festival de la Felicidad 2024, reforzando el sentido de comunidad entre los asistentes. Además de ser una herramienta visual, estos dispositivos serán un símbolo de unión, alegría y participación colectiva, convirtiéndose en un elemento esencial para el éxito y el impacto del evento.
DOI: 10.17632/t4z7d7fm98
title: LDHU3_01.0270

description: DNA excision/ repair protein SNF2; Leishmania donovani
DOI: 10.17632/v8jf29whrx
title: LINF_080008900

description: Hypothetical protein - conserved; Leishmania infantum (strain JPCM5)