cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3376252.v1
title: TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription <i>via</i> facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters

description: Cells control their metabolism through modulating the anabolic and catabolic pathways. TP53INP2/DOR (tumor protein p53 inducible nuclear protein 2), participates in cell catabolism by serving as a promoter of autophagy. Here we uncover a novel function of TP53INP2 in protein synthesis, a major biosynthetic and energy consuming anabolic process. TP53INP2 localizes to the nucleolus through its nucleolar localization signal (NoLS) located at the C-terminal domain. Chromatin immunoprecipitation (ChIP) assays detected an association of TP53INP2 with the ribosomal DNA (rDNA), when exclusion of TP53INP2 from the nucleolus repressed rDNA promoter activity and the production of ribosomal RNA (rRNA) and proteins. The removal of TP53INP2 also impaired the association of the POLR1/RNA polymerase I preinitiation complex (PIC) with rDNA. Further, TP53INP2 interacts directly with POLR1 PIC, and is required for the assembly of the complex. These data indicate that TP53INP2 promotes ribosome biogenesis through facilitating rRNA synthesis at the nucleolus, suggesting a dual role of TP53INP2 in cell metabolism, assisting anabolism on the nucleolus, and stimulating catabolism off the nucleolus.
DOI: 10.6084/m9.figshare.3376243
title: Steven Dinger, David Rubin and Peter Fridjhon, Thermal Excitation of Gadolinium-based Contrast Agents Using Spin Resonance, PLOS ONE Journal Data, 2016

description: The data contains the temperature results of the four tested gadolinium contrast agents: Magnevist, MultiHance, Dotarem and ProHance. As well as two control substances: distilled water and saline. The data also contains the decay and pulse response of ProHance.<br>
DOI: 10.6084/m9.figshare.3376243.v2
title: Steven Dinger, David Rubin and Peter Fridjhon, Thermal Excitation of Gadolinium-based Contrast Agents Using Spin Resonance, PLOS ONE Journal Data, 2016

description: The data contains the temperature results of the four tested gadolinium contrast agents: Magnevist, MultiHance, Dotarem and ProHance. As well as two control substances: distilled water and saline. The data also contains the decay and pulse response of ProHance.<br>
DOI: 10.6084/m9.figshare.3376243.v1
title: Steven Dinger David Rubin and Peter Fridjhon, Thermal Excitation of Gadolinium-based Contrast Agents Using Spin Resonance, PLOS ONE Journal Data, 2016

description: The data contains the temperature results of the four tested gadolinium contrast agents: Magnevist, MultiHance, Dotarem and ProHance. As well as two control substances: distilled water and saline. The data also contains the decay and pulse response of ProHance.<br>
DOI: 10.6084/m9.figshare.3376189
title: Molecular Characterization of Lactobacilli Isolated from <i>Piper betle</i> L. var. Pachaikodi and Comparative Analysis of the Antimicrobial Effects of Isolate <i>Lactobacillus plantarum</i> KJB23 and Betel Leaves Extract

description: Traditionally <i>Piper betle</i> L. leaves have been used in India for fermenting certain foods. In our previous study, while fermenting Uttapam batter along with <i>Piper betle</i> L. var. Pachaikodi leaves led to suppression of gas formation and altered Lactic acid bacteria profile, especially in bacilli isolates compared to those observed in plain Uttapam batter fermentation. Hence, the aim of the present study was to understand the rationale behind these changes through characterization of <i>Lactobacillus</i> isolates from <i>Piper betle</i> L. var. Pachaikodi and also the leaves extracts for antimicrobial activity. Out of 72 isolates obtained from the betel leaves, only 10 isolates were bacilli which were chosen for their molecular characterization and to elucidate their inhibitory effects against major food borne pathogens and gas-forming bacteria and to compare with the effect of betel leaves extract. Random amplified polymorphic DNA (RAPD)-PCR and phenotype analysis was used to differentiate the isolates at strain level, 16S rRNA gene sequence for phylogenetic analysis and species-specific multiplex PCR analysis for sub-species identification. All isolates were identified as <i>Lactobacillus plantarum</i> subsp. <i>plantarum</i>. All <i>Lactobacillus</i> isolates were indigenous to leaf as they were resistant to betel leaves extract and showed maximum activity against some LAB and non-LAB indicator strains except <i>Lactobacillus plantarum</i> MTCC 6160 which was resistant. Among them, KJB23, 36 and 47 were the most effective. Particularly, the isolate KJB23 and ethanolic betal leaf extract showed rivaling inhibitory activity against major food borne pathogens, while dissimilar activity against gas forming bacteria. This study revealed that either <i>Piper betle</i> L. leaf or <i>Lactobacillus</i> strains from the leaves can be valuable for food applications when added to fermented products.
DOI: 10.6084/m9.figshare.3376189.v1
title: Molecular Characterization of Lactobacilli Isolated from <i>Piper betle</i> L. var. Pachaikodi and Comparative Analysis of the Antimicrobial Effects of Isolate <i>Lactobacillus plantarum</i> KJB23 and Betel Leaves Extract

description: Traditionally <i>Piper betle</i> L. leaves have been used in India for fermenting certain foods. In our previous study, while fermenting Uttapam batter along with <i>Piper betle</i> L. var. Pachaikodi leaves led to suppression of gas formation and altered Lactic acid bacteria profile, especially in bacilli isolates compared to those observed in plain Uttapam batter fermentation. Hence, the aim of the present study was to understand the rationale behind these changes through characterization of <i>Lactobacillus</i> isolates from <i>Piper betle</i> L. var. Pachaikodi and also the leaves extracts for antimicrobial activity. Out of 72 isolates obtained from the betel leaves, only 10 isolates were bacilli which were chosen for their molecular characterization and to elucidate their inhibitory effects against major food borne pathogens and gas-forming bacteria and to compare with the effect of betel leaves extract. Random amplified polymorphic DNA (RAPD)-PCR and phenotype analysis was used to differentiate the isolates at strain level, 16S rRNA gene sequence for phylogenetic analysis and species-specific multiplex PCR analysis for sub-species identification. All isolates were identified as <i>Lactobacillus plantarum</i> subsp. <i>plantarum</i>. All <i>Lactobacillus</i> isolates were indigenous to leaf as they were resistant to betel leaves extract and showed maximum activity against some LAB and non-LAB indicator strains except <i>Lactobacillus plantarum</i> MTCC 6160 which was resistant. Among them, KJB23, 36 and 47 were the most effective. Particularly, the isolate KJB23 and ethanolic betal leaf extract showed rivaling inhibitory activity against major food borne pathogens, while dissimilar activity against gas forming bacteria. This study revealed that either <i>Piper betle</i> L. leaf or <i>Lactobacillus</i> strains from the leaves can be valuable for food applications when added to fermented products.
DOI: 10.6084/m9.figshare.3376186
title: Frederick Orentlich

description: Frederick Orentlich is focused on senior financial matters including asset growth and protection assisting thousands of clients to date.<br><br>
DOI: 10.6084/m9.figshare.3376186.v1
title: Frederick Orentlich

description: Frederick Orentlich is focused on senior financial matters including asset growth and protection assisting thousands of clients to date.<br><br>
DOI: 10.6084/m9.figshare.3376117
title: Visualización de una serie de tiempo de temperatura media en la ciudad de Maracaibo, estado Zulia, Venezuela

description: Ejemplo ilustrativo del uso un gráfico radial en R (paquete plotrix) para mostrar las temperaturas a lo largo del año y durante varios años. Basado en datos de la estación climática 804070, serial 1015, ubicada en la ciudad de Maracaibo, estado Zulia, Venezuela para el periodo 1953 al 2012.
DOI: 10.6084/m9.figshare.3376114
title: Tables of results from the Monte Carlo study

description: The results of the Monte Carlo studies for the paper “Statistical Properties of Four Effect Size Measures for Mediation Models” are summarized in 64 tables. The first 16 tables contain values of bias, relative bias, efficiency, and standardized bias of point estimates of effect size measures in the single and parallel two-mediator models. Tables 17-56 contain values of power, Type I error rate, coverage, interval width, and imbalance for interval estimates of effect size measures in the single and parallel two-mediator models. Tables 57-64 contain values of relative bias of the Bayesian point summaries and coverage of equal-tail (ET) and highest posterior density (HPD) credibility intervals for the effect size measures in the single and two mediator models.
DOI: 10.6084/m9.figshare.3376114.v1
title: Tables of results from the Monte Carlo study

description: The results of the Monte Carlo studies for the paper “Statistical Properties of Four Effect Size Measures for Mediation Models” are summarized in 64 tables. The first 16 tables contain values of bias, relative bias, efficiency, and standardized bias of point estimates of effect size measures in the single and parallel two-mediator models. Tables 17-56 contain values of power, Type I error rate, coverage, interval width, and imbalance for interval estimates of effect size measures in the single and parallel two-mediator models. Tables 57-64 contain values of relative bias of the Bayesian point summaries and coverage of equal-tail (ET) and highest posterior density (HPD) credibility intervals for the effect size measures in the single and two mediator models.
DOI: 10.6084/m9.figshare.3376093
title: Sample SAS code for the Monte Carlo Study

description: These SAS files are sample code used for the Monte Carlo studies in a manuscript on statistical properties of four effect size measures for the mediated effect.Citation:Miočević, M., O’Rourke, H. P., MacKinnon, D. P., & Brown, H. C. (2016). <i>The bias and efficiency of five effect size measures for mediation models</i>. Under review at Behavior Research Methods.
DOI: 10.6084/m9.figshare.3371176
title: Correspondence administrative divisions level

description: Correspondence administrative divisions level in Madagascar<br>
DOI: 10.6084/m9.figshare.3371152
title: Patient participation in the development of a clinical guideline for inherited retinal dystrophies

description: <b>Objective</b>: To identify the most relevant self-perceived health problems and unmet needs among adults with inherited retinal dystrophies (IRDs) in order to incorporate patients’ perspective from the initial design of a clinical practice guideline (CPG) for IRDs in Spain. <b>Research design and methods</b>: A systematic review (SR) and a survey according to the Delphi method were carried out. <b>Main Outcome Measures</b>: Self-perceived health problems, unmet needs of care and treatment expectations related to IRDs. <b>Results</b>: From the SR, no information was found regarding unmet health care needs or dissatisfaction with health care services. In the survey, the most significant self-reported health problems were progressive decrease in visual acuity, visual field loss, abnormal sensitivity to light or glare, and night blindness. The main unmet needs were scarcity of disease information, lack of protocols for effective disease management and limited professional empathy. Treatment expectations were focused on the availability of protective and aids devices, easier access to rehabilitative services and psychological support. <b>Conclusion</b>: Patient involvement in CPG development helps to reduce the gap between the drawbacks of the routine clinical management and real-life needs of patients, especially in the context of rare diseases as IRDs where evidence-based therapies are scarce.
DOI: 10.6084/m9.figshare.3371152.v1
title: Patient participation in the development of a clinical guideline for inherited retinal dystrophies

description: <b>Objective</b>: To identify the most relevant self-perceived health problems and unmet needs among adults with inherited retinal dystrophies (IRDs) in order to incorporate patients’ perspective from the initial design of a clinical practice guideline (CPG) for IRDs in Spain. <b>Research design and methods</b>: A systematic review (SR) and a survey according to the Delphi method were carried out. <b>Main Outcome Measures</b>: Self-perceived health problems, unmet needs of care and treatment expectations related to IRDs. <b>Results</b>: From the SR, no information was found regarding unmet health care needs or dissatisfaction with health care services. In the survey, the most significant self-reported health problems were progressive decrease in visual acuity, visual field loss, abnormal sensitivity to light or glare, and night blindness. The main unmet needs were scarcity of disease information, lack of protocols for effective disease management and limited professional empathy. Treatment expectations were focused on the availability of protective and aids devices, easier access to rehabilitative services and psychological support. <b>Conclusion</b>: Patient involvement in CPG development helps to reduce the gap between the drawbacks of the routine clinical management and real-life needs of patients, especially in the context of rare diseases as IRDs where evidence-based therapies are scarce.
DOI: 10.6084/m9.figshare.3371038
title: Sero-prevalence data in humans

description: This data set was described and analyzed by Andriamandimby et al.,2010. A nationwide cross-sectional serological survey was achieved in 2008 and 2009.<br>
DOI: 10.6084/m9.figshare.3371035
title: RVF sero-prevalence data in animals

description: Data were provided by Malagasy Veterinary Services, Pasteur Institute of Madagascar, and FAO. <br>A partial analysis of these data was already published Jeanmaire, 2011. They were collected during the last RVF epidemic in 2008 in Madagascar.<br><br>
DOI: 10.6084/m9.figshare.3370972
title: Slight pressure imbalances can affect accuracy and precision of dual inlet-based clumped isotope analysis

description: It is well known that a subtle nonlinearity can occur during clumped isotope analysis of CO<sub>2</sub> that – if remaining unaddressed – limits accuracy. The nonlinearity is induced by a negative background on the <i>m</i>/<i>z</i> 47 ion Faraday cup, whose magnitude is correlated with the intensity of the <i>m</i>/<i>z</i> 44 ion beam. The origin of the negative background remains unclear, but is possibly due to secondary electrons. Usually, CO<sub>2</sub> gases of distinct bulk isotopic compositions are equilibrated at 1000 °C and measured along with the samples in order to be able to correct for this effect. Alternatively, measured <i>m</i>/<i>z</i> 47 beam intensities can be corrected for the contribution of secondary electrons after monitoring how the negative background on <i>m</i>/<i>z</i> 47 evolves with the intensity of the <i>m</i>/<i>z</i> 44 ion beam. The latter correction procedure seems to work well if the <i>m</i>/<i>z</i> 44 cup exhibits a wider slit width than the <i>m</i>/<i>z</i> 47 cup. Here we show that the negative <i>m</i>/<i>z</i> 47 background affects precision of dual inlet-based clumped isotope measurements of CO<sub>2</sub> unless raw <i>m</i>/<i>z</i> 47 intensities are directly corrected for the contribution of secondary electrons. Moreover, inaccurate results can be obtained even if the heated gas approach is used to correct for the observed nonlinearity. The impact of the negative background on accuracy and precision arises from small imbalances in <i>m</i>/<i>z</i> 44 ion beam intensities between reference and sample CO<sub>2</sub> measurements. It becomes the more significant the larger the relative contribution of secondary electrons to the <i>m</i>/<i>z</i> 47 signal is and the higher the flux rate of CO<sub>2</sub> into the ion source is set. These problems can be overcome by correcting the measured <i>m</i>/<i>z</i> 47 ion beam intensities of sample and reference gas for the contributions deriving from secondary electrons after scaling these contributions to the intensities of the corresponding <i>m</i>/<i>z</i> 49 ion beams. Accuracy and precision of this correction are demonstrated by clumped isotope analysis of three internal carbonate standards. The proposed correction scheme can be easily applied if the slit width of the <i>m</i>/<i>z</i> 49 Faraday cup is bigger than that of the <i>m</i>/<i>z</i> 47 cup.
DOI: 10.6084/m9.figshare.3370972.v1
title: Slight pressure imbalances can affect accuracy and precision of dual inlet-based clumped isotope analysis

description: It is well known that a subtle nonlinearity can occur during clumped isotope analysis of CO<sub>2</sub> that – if remaining unaddressed – limits accuracy. The nonlinearity is induced by a negative background on the <i>m</i>/<i>z</i> 47 ion Faraday cup, whose magnitude is correlated with the intensity of the <i>m</i>/<i>z</i> 44 ion beam. The origin of the negative background remains unclear, but is possibly due to secondary electrons. Usually, CO<sub>2</sub> gases of distinct bulk isotopic compositions are equilibrated at 1000 °C and measured along with the samples in order to be able to correct for this effect. Alternatively, measured <i>m</i>/<i>z</i> 47 beam intensities can be corrected for the contribution of secondary electrons after monitoring how the negative background on <i>m</i>/<i>z</i> 47 evolves with the intensity of the <i>m</i>/<i>z</i> 44 ion beam. The latter correction procedure seems to work well if the <i>m</i>/<i>z</i> 44 cup exhibits a wider slit width than the <i>m</i>/<i>z</i> 47 cup. Here we show that the negative <i>m</i>/<i>z</i> 47 background affects precision of dual inlet-based clumped isotope measurements of CO<sub>2</sub> unless raw <i>m</i>/<i>z</i> 47 intensities are directly corrected for the contribution of secondary electrons. Moreover, inaccurate results can be obtained even if the heated gas approach is used to correct for the observed nonlinearity. The impact of the negative background on accuracy and precision arises from small imbalances in <i>m</i>/<i>z</i> 44 ion beam intensities between reference and sample CO<sub>2</sub> measurements. It becomes the more significant the larger the relative contribution of secondary electrons to the <i>m</i>/<i>z</i> 47 signal is and the higher the flux rate of CO<sub>2</sub> into the ion source is set. These problems can be overcome by correcting the measured <i>m</i>/<i>z</i> 47 ion beam intensities of sample and reference gas for the contributions deriving from secondary electrons after scaling these contributions to the intensities of the corresponding <i>m</i>/<i>z</i> 49 ion beams. Accuracy and precision of this correction are demonstrated by clumped isotope analysis of three internal carbonate standards. The proposed correction scheme can be easily applied if the slit width of the <i>m</i>/<i>z</i> 49 Faraday cup is bigger than that of the <i>m</i>/<i>z</i> 47 cup.
DOI: 10.6084/m9.figshare.3370969
title: LinghubCMLQueries.pdf

description: SPARQL queries from Corpora List on Linghub
DOI: 10.6084/m9.figshare.3370939
title: Cognitive assessment in Amyotrophic Lateral Sclerosis by means of P300-Brain Computer Interface: a preliminary study

description: <i>Objective</i>: To investigate the use of P300-based Brain Computer Interface (BCI) technology for the administration of motor-verbal free cognitive tests in Amyotrophic Lateral Sclerosis (ALS). <i>Methods</i>: We recruited 15 ALS patients and 15 age- and education-matched healthy subjects. All participants underwent a BCI-based neuropsychological assessment, together with two standard cognitive screening tools (FAB, MoCA), two psychological questionnaires (BDI, STAI-Y) and a usability questionnaire. For patients, clinical and respiratory examinations were also performed, together with a behavioural assessment (FBI). <i>Results</i>: Correlations were observed between standard cognitive and BCI-based neuropsychological assessment, mainly concerning execution times in the ALS group. Moreover, patients provided positive rates concerning the BCI perceived usability and subjective experience. Finally, execution times at the BCI-based neuropsychological assessment were useful to discriminate patients from controls, with patients achieving lower processing speed than controls regarding executive functions. <i>Conclusions</i>: The developed motor-verbal free neuropsychological battery represents an innovative approach, that could provide relevant information for clinical practice and ethical issues. Its use for cognitive evaluation throughout the course of ALS, currently not available by means of standard assessment, must be addressed in further longitudinal validation studies. Further work will be aimed at refining the developed system and enlarging the cognitive spectrum investigated.
DOI: 10.6084/m9.figshare.3370939.v1
title: Cognitive assessment in Amyotrophic Lateral Sclerosis by means of P300-Brain Computer Interface: a preliminary study

description: <i>Objective</i>: To investigate the use of P300-based Brain Computer Interface (BCI) technology for the administration of motor-verbal free cognitive tests in Amyotrophic Lateral Sclerosis (ALS). <i>Methods</i>: We recruited 15 ALS patients and 15 age- and education-matched healthy subjects. All participants underwent a BCI-based neuropsychological assessment, together with two standard cognitive screening tools (FAB, MoCA), two psychological questionnaires (BDI, STAI-Y) and a usability questionnaire. For patients, clinical and respiratory examinations were also performed, together with a behavioural assessment (FBI). <i>Results</i>: Correlations were observed between standard cognitive and BCI-based neuropsychological assessment, mainly concerning execution times in the ALS group. Moreover, patients provided positive rates concerning the BCI perceived usability and subjective experience. Finally, execution times at the BCI-based neuropsychological assessment were useful to discriminate patients from controls, with patients achieving lower processing speed than controls regarding executive functions. <i>Conclusions</i>: The developed motor-verbal free neuropsychological battery represents an innovative approach, that could provide relevant information for clinical practice and ethical issues. Its use for cognitive evaluation throughout the course of ALS, currently not available by means of standard assessment, must be addressed in further longitudinal validation studies. Further work will be aimed at refining the developed system and enlarging the cognitive spectrum investigated.