cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.7zmgrg
title: Occurrence Download

description: A dataset containing 8090 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Plethodon vehiculum"
 ]
}

 The dataset includes 8090 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005496-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e239324
title: Dermal exposure to the immunomodulatory antimicrobial chemical triclosan alters the skin barrier integrity and microbiome in mice

description: Triclosan is an antimicrobial chemical used in healthcare settings that can be absorbed through the skin. Exposure to triclosan has been positively associated with food and aeroallergy and asthma exacerbation in humans and, although not directly sensitizing, has been demonstrated to augment the allergic response in a mouse model of asthma. The skin barrier and microbiome are thought to play important roles in mediating inflammation and allergy and disruptions may contribute to development of allergic disease. To investigate potential connections of the skin barrier and microbiome with immune responses to triclosan, SKH1 mice were dermally exposed to triclosan (0.5-2%) or vehicle for up to 7 consecutive days.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239324v1
title: Dermal exposure to the immunomodulatory antimicrobial chemical triclosan alters the skin barrier integrity and microbiome in mice

description: Triclosan is an antimicrobial chemical used in healthcare settings that can be absorbed through the skin. Exposure to triclosan has been positively associated with food and aeroallergy and asthma exacerbation in humans and, although not directly sensitizing, has been demonstrated to augment the allergic response in a mouse model of asthma. The skin barrier and microbiome are thought to play important roles in mediating inflammation and allergy and disruptions may contribute to development of allergic disease. To investigate potential connections of the skin barrier and microbiome with immune responses to triclosan, SKH1 mice were dermally exposed to triclosan (0.5-2%) or vehicle for up to 7 consecutive days.
description: Data downloaded 5/20/2025
DOI: 10.6084/m9.figshare.30472022.v1
title: Novel pyrido[2,3-d]pyrimidines for bioimaging: Effect of water content on enhanced fluorescence and the mechanism of aggregation-induced blue-shifted emission

description: This dataset contains raw data from the spectroscopis and biological analyses published in the article entitled “Novel pyrido[2,3-d]pyrimidines for bioimaging: Effect of water content on enhanced fluorescence and the mechanism of aggregation-induced blue-shifted emission” in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (doi: 10.1016/j.saa.2025.126729). The raw data were generated during fluorescence and aggregation studies, as well as cytotoxicity analyses. The data provided correspond to figures published in the main article and supporting material file.
DOI: 10.6084/m9.figshare.30472022
title: Novel pyrido[2,3-d]pyrimidines for bioimaging: Effect of water content on enhanced fluorescence and the mechanism of aggregation-induced blue-shifted emission

description: This dataset contains raw data from the spectroscopis and biological analyses published in the article entitled “Novel pyrido[2,3-d]pyrimidines for bioimaging: Effect of water content on enhanced fluorescence and the mechanism of aggregation-induced blue-shifted emission” in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (doi: 10.1016/j.saa.2025.126729). The raw data were generated during fluorescence and aggregation studies, as well as cytotoxicity analyses. The data provided correspond to figures published in the main article and supporting material file.
DOI: 10.3886/e239320
title: Automated oil vapor inhalation exposure system

description: In August 2020 there were over 186,000 employees in the oil and gas extraction industry in the United States (United States Department of Labor. Bureau of Labor Statistics, 2020). Many workers in the upstream oil extraction industry have potential risk of crude oil vapor (COV) inhalation. There are many current knowledge gaps regarding the health effects from inhalation of complex mixtures found in crude oil vapors. To aid research in filling these gaps, an automated system that could carefully deliver and control the COV concentration within an animal inhalation exposure chamber was needed. The objective of this project was to develop an automated computer-controlled system to expose small laboratory animals to precise concentrations of crude oil vapor (COV).
description: Data downloaded 5/20/2025
DOI: 10.3886/e239320v1
title: Automated oil vapor inhalation exposure system

description: In August 2020 there were over 186,000 employees in the oil and gas extraction industry in the United States (United States Department of Labor. Bureau of Labor Statistics, 2020). Many workers in the upstream oil extraction industry have potential risk of crude oil vapor (COV) inhalation. There are many current knowledge gaps regarding the health effects from inhalation of complex mixtures found in crude oil vapors. To aid research in filling these gaps, an automated system that could carefully deliver and control the COV concentration within an animal inhalation exposure chamber was needed. The objective of this project was to develop an automated computer-controlled system to expose small laboratory animals to precise concentrations of crude oil vapor (COV).
description: Data downloaded 5/20/2025
DOI: 10.3886/e239325
title: High-fat western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis

description: Adipose tissue (AT), an endocrine organ, plays a central role in maintenance of whole-body energy homeostasis through its release of adipokines. Obesity, affecting over 40% of American adults, disrupts adipocyte metabolism leading to chronic systemic inflammation and metabolic dysfunction (MetDys). MetDys is associated with impaired lung function, pulmonary hypertension, and asthma. The aim of this study was to investigate the effects of high-fat Western diet (HFWD)-consumption on silica-induced pulmonary inflammation and fibrosis in the F344 rat.
description: Downloaded 5/20/2025
DOI: 10.3886/e239325v1
title: High-fat western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis

description: Adipose tissue (AT), an endocrine organ, plays a central role in maintenance of whole-body energy homeostasis through its release of adipokines. Obesity, affecting over 40% of American adults, disrupts adipocyte metabolism leading to chronic systemic inflammation and metabolic dysfunction (MetDys). MetDys is associated with impaired lung function, pulmonary hypertension, and asthma. The aim of this study was to investigate the effects of high-fat Western diet (HFWD)-consumption on silica-induced pulmonary inflammation and fibrosis in the F344 rat.
description: Downloaded 5/20/2025
DOI: 10.3886/e239316
title: Influence of Impurities from Manufacturing Process on the Toxicity Profile of Boron Nitride Nanotubes

description: The toxicity of boron nitride nanotubes (BNNTs) is confounded by the various manufacturing and purification strategies employed targeted to remove 30-60% of the residuals and impurities. Four BNNTs manufactured by the induction thermal plasma process allowed us to assess the influence of these residuals/impurities on the toxicity profile of BNNTs by producing a gradient of BNNT purity levels through sequential gas purification, and water and solvent washing, followed by filtration. Extensive characterization including Infrared, x-ray spectroscopy, thermogravimetric analysis, size, charge, surface area and density allowed characterization of the alteration in physicochemical properties as the material went through sequential purification. The material from each step was screened using acellular and in vitro assays that evaluated general toxicity, mechanisms of toxicity and macrophage function.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239316v1
title: Influence of Impurities from Manufacturing Process on the Toxicity Profile of Boron Nitride Nanotubes

description: The toxicity of boron nitride nanotubes (BNNTs) is confounded by the various manufacturing and purification strategies employed targeted to remove 30-60% of the residuals and impurities. Four BNNTs manufactured by the induction thermal plasma process allowed us to assess the influence of these residuals/impurities on the toxicity profile of BNNTs by producing a gradient of BNNT purity levels through sequential gas purification, and water and solvent washing, followed by filtration. Extensive characterization including Infrared, x-ray spectroscopy, thermogravimetric analysis, size, charge, surface area and density allowed characterization of the alteration in physicochemical properties as the material went through sequential purification. The material from each step was screened using acellular and in vitro assays that evaluated general toxicity, mechanisms of toxicity and macrophage function.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239323
title: Revealing the Structural and Chemical Properties of Copper-based Nanoparticles Released from Copper Treated Wood-Dataset

description: Copper-based preservatives consisting of micronized and nanoscale copper
 particles have been widely used in applications for wood protection. 
The presence of micronized/nanoscale particles and soluble aqueous 
copper in copper-treated wood has raised questions regarding the forms 
of released particles and the potential hazards of exposure during the 
use of these products. However, the lack of a comprehensive 
understanding of the chemistry of these Cu species is limiting the 
future investigation of the toxicity of these materials and their 
potential health impact on workers. In this work, we used a combination 
of scanning transmission electron microscope (STEM) and electron energy 
loss spectroscopy (EELS) to analyze the particles released during the 
sanding/sawing of copper-treated lumber. We have demonstrated using EELS
 Cu L2,3 edges with comparative reference spectra to determine the Cu 
species. Three types of species, including basic copper carbonate (BCC),
 Cu(0), and Cu(II)-Wood complex, were identified in released wood dust 
particles. The unbound copper particles also exist as a form of BCC or 
reduced Cu(0). The morphologies and chemical states of emitted copper 
particles indicate the potential chemical transformation due to 
copper-wood interactions.<br>
description: Data downloaded 5/20/2025
DOI: 10.3886/e239323v1
title: Revealing the Structural and Chemical Properties of Copper-based Nanoparticles Released from Copper Treated Wood-Dataset

description: Copper-based preservatives consisting of micronized and nanoscale copper
 particles have been widely used in applications for wood protection. 
The presence of micronized/nanoscale particles and soluble aqueous 
copper in copper-treated wood has raised questions regarding the forms 
of released particles and the potential hazards of exposure during the 
use of these products. However, the lack of a comprehensive 
understanding of the chemistry of these Cu species is limiting the 
future investigation of the toxicity of these materials and their 
potential health impact on workers. In this work, we used a combination 
of scanning transmission electron microscope (STEM) and electron energy 
loss spectroscopy (EELS) to analyze the particles released during the 
sanding/sawing of copper-treated lumber. We have demonstrated using EELS
 Cu L2,3 edges with comparative reference spectra to determine the Cu 
species. Three types of species, including basic copper carbonate (BCC),
 Cu(0), and Cu(II)-Wood complex, were identified in released wood dust 
particles. The unbound copper particles also exist as a form of BCC or 
reduced Cu(0). The morphologies and chemical states of emitted copper 
particles indicate the potential chemical transformation due to 
copper-wood interactions.<br>
description: Data downloaded 5/20/2025
DOI: 10.3886/e239319
title: Lung Toxicity Profile of Inhaled Copper-Nickel Welding Fume in A/J Mice

description: The process of stainless steel welding creates fumes rich in carcinogenic metals such as chromium (Cr). Welding consumables devoid of Cr are being produced in attempt to limit worker exposures to potentially toxic and carcinogenic metals. The study objective was to characterize a copper-nickel (Cu-Ni) fume generated using gas metal arc welding (GMAW) and determine the pulmonary deposition and toxicity of the fume in mice exposed by inhalation. Male A/J mice (6 – 8 weeks of age) were exposed to air or Cu-Ni welding fumes for 2 (low deposition) or 4 (high deposition) hours/day for 10 days. Mice were sacrificed and bronchoalveolar lavage (BAL), macrophage function, and histopathological analysis were performed at various timepoints post-exposure to evaluate resolution. Characterization of the fume indicated that most of the particles were between 0.1 and 1 µm in diameter, with a mass median aerodynamic diameter of 0.43 µm. Metal content of the fume was primarily Cu (~76%) and Ni (~12%). After exposure, BAL macrophages had a reduced ability to phagocytose E. coli at 1 and 7 days and lung cytotoxicity was evident and significant (&gt;12-19% fold change). Loss of body weight was also significant at these two early timepoints. Lung inflammation, the predominant lesion identified by histopathology, was observed as a subacute response early that progressively resolved by 28 days with only macrophage aggregates remaining late (84 days). Future studies are planned to investigate the tumorigenic potential of Cu-Ni fume in A/J mice.Read less
description: Data downloaded 5/20/2025
DOI: 10.3886/e239319v1
title: Lung Toxicity Profile of Inhaled Copper-Nickel Welding Fume in A/J Mice

description: The process of stainless steel welding creates fumes rich in carcinogenic metals such as chromium (Cr). Welding consumables devoid of Cr are being produced in attempt to limit worker exposures to potentially toxic and carcinogenic metals. The study objective was to characterize a copper-nickel (Cu-Ni) fume generated using gas metal arc welding (GMAW) and determine the pulmonary deposition and toxicity of the fume in mice exposed by inhalation. Male A/J mice (6 – 8 weeks of age) were exposed to air or Cu-Ni welding fumes for 2 (low deposition) or 4 (high deposition) hours/day for 10 days. Mice were sacrificed and bronchoalveolar lavage (BAL), macrophage function, and histopathological analysis were performed at various timepoints post-exposure to evaluate resolution. Characterization of the fume indicated that most of the particles were between 0.1 and 1 µm in diameter, with a mass median aerodynamic diameter of 0.43 µm. Metal content of the fume was primarily Cu (~76%) and Ni (~12%). After exposure, BAL macrophages had a reduced ability to phagocytose E. coli at 1 and 7 days and lung cytotoxicity was evident and significant (&gt;12-19% fold change). Loss of body weight was also significant at these two early timepoints. Lung inflammation, the predominant lesion identified by histopathology, was observed as a subacute response early that progressively resolved by 28 days with only macrophage aggregates remaining late (84 days). Future studies are planned to investigate the tumorigenic potential of Cu-Ni fume in A/J mice.Read less
description: Data downloaded 5/20/2025
DOI: 10.3886/e239310
title: Effects of inhaled tier-2 diesel engine exhaust on immunotoxicity in a rat model: A hazard identification study. Part III. Immunotoxicology

description: Diesel exhaust (DE) is an air pollutant containing gaseous compounds and particulate matter. Diesel engines are common on gas extraction and oil sites, leading to complex DE exposure to a broad range of compounds through occupational settings. The US EPA concluded that short-term exposure to DE leads to allergic inflammatory disorders of the airways. To further evaluate the immunotoxicity of DE, the effects of whole-body inhalation of 0.2 and 1 mg/m3 DE (total carbon; 6 h/d for 4 days) were investigated 1-, 7-, and 27-days post exposure in Sprague-Dawley rats using an occupationally relevant exposure system. DE exposure of 1 mg/m3 increased total cellularity, number of CD4+ and CD8+ T-cells, and B-cells at 1 d post-exposure in the lung lymph nodes. At 7 d post-exposure to 1 mg/m3, cellularity and the number of CD4+ and CD8+ T-cells decreased in the LLNs. In the bronchoalveolar lavage, B-cell number and frequency increased at 1 d post-exposure, Natural Killer cell number and frequency decreased at 7 d post-exposure, and at 27 d post-exposure CD8+ T-cell and CD11b+ cell number and frequency decreased with 0.2 mg/m3 exposure. In the spleen, 0.2 mg/m3 increased CD4+ T-cell frequency at 1 and 7 d post-exposure and at 27 d post-exposure increased CD4+ and CD8+ T-cell number and CD8+ T-cell frequency. B-cells were the only immune cell subset altered in the three tissues (spleen, LLNs, and BALF), suggesting the induction of the adaptive immune response. The increase in lymphocytes in several different organ types also suggests an induction of a systemic inflammatory response occurring following DE exposure. These results show that DE exposure induced modifications of cellularity of phenotypic subsets that may impair immune function and contribute to airway inflammation induced by DE exposure in rats.
description: Data downloaded 5/20/2025
DOI: 10.3886/e239310v1
title: Effects of inhaled tier-2 diesel engine exhaust on immunotoxicity in a rat model: A hazard identification study. Part III. Immunotoxicology

description: Diesel exhaust (DE) is an air pollutant containing gaseous compounds and particulate matter. Diesel engines are common on gas extraction and oil sites, leading to complex DE exposure to a broad range of compounds through occupational settings. The US EPA concluded that short-term exposure to DE leads to allergic inflammatory disorders of the airways. To further evaluate the immunotoxicity of DE, the effects of whole-body inhalation of 0.2 and 1 mg/m3 DE (total carbon; 6 h/d for 4 days) were investigated 1-, 7-, and 27-days post exposure in Sprague-Dawley rats using an occupationally relevant exposure system. DE exposure of 1 mg/m3 increased total cellularity, number of CD4+ and CD8+ T-cells, and B-cells at 1 d post-exposure in the lung lymph nodes. At 7 d post-exposure to 1 mg/m3, cellularity and the number of CD4+ and CD8+ T-cells decreased in the LLNs. In the bronchoalveolar lavage, B-cell number and frequency increased at 1 d post-exposure, Natural Killer cell number and frequency decreased at 7 d post-exposure, and at 27 d post-exposure CD8+ T-cell and CD11b+ cell number and frequency decreased with 0.2 mg/m3 exposure. In the spleen, 0.2 mg/m3 increased CD4+ T-cell frequency at 1 and 7 d post-exposure and at 27 d post-exposure increased CD4+ and CD8+ T-cell number and CD8+ T-cell frequency. B-cells were the only immune cell subset altered in the three tissues (spleen, LLNs, and BALF), suggesting the induction of the adaptive immune response. The increase in lymphocytes in several different organ types also suggests an induction of a systemic inflammatory response occurring following DE exposure. These results show that DE exposure induced modifications of cellularity of phenotypic subsets that may impair immune function and contribute to airway inflammation induced by DE exposure in rats.
description: Data downloaded 5/20/2025
DOI: 10.15468/dl.7a22mn
title: Occurrence Download

description: A dataset containing 172 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-84.76293 41.31624,-82.53505 41.31624,-82.53505 43.87062,-84.76293 43.87062,-84.76293 41.31624))",
 "HasCoordinate is true",
 "TaxonKey is Agrilus planipennis",
 "Year 2003-2024"
 ]
}

 The dataset includes 172 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005498-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3886/e239322
title: Characterizing dynamic atmosphere generation system performance for analytical method development

description: Laboratory-generated environments are substantial parts of the work involved in developing and validating methods for sampling volatile organic compounds (VOCs) in workplace atmospheres. We assessed the variability of samples produced by our dynamic atmosphere generation system designed for VOC generation and sampling. The characterization of bias and variability was conducted across various atmospheres containing pure n-heptane as well as mixtures of VOCs, which were collected using coconut shell charcoal tubes. The analysis of VOCs from these charcoal tubes was evaluated to reveal the variability from multiple sources: the generation of the atmosphere, the sampling process, and the analytical procedures. This research aimed to quantify the extent of variability from these sources and to estimate the sampling variability associated with our dynamic generation system. Our findings indicated that sampling variability ranged from 2% for pure n-heptane to 12% for a component within a ten-VOC mixture. Notably, sample variability increased with lower concentration levels and in mixtures compared to single-component atmospheres. This study provides a foundational reference for future experiments focused on atmosphere sampling performance at lower concentrations and in mixed VOC environments.<br>
description: Data downloaded: 5/20/2025
DOI: 10.3886/e239322v1
title: Characterizing dynamic atmosphere generation system performance for analytical method development

description: Laboratory-generated environments are substantial parts of the work involved in developing and validating methods for sampling volatile organic compounds (VOCs) in workplace atmospheres. We assessed the variability of samples produced by our dynamic atmosphere generation system designed for VOC generation and sampling. The characterization of bias and variability was conducted across various atmospheres containing pure n-heptane as well as mixtures of VOCs, which were collected using coconut shell charcoal tubes. The analysis of VOCs from these charcoal tubes was evaluated to reveal the variability from multiple sources: the generation of the atmosphere, the sampling process, and the analytical procedures. This research aimed to quantify the extent of variability from these sources and to estimate the sampling variability associated with our dynamic generation system. Our findings indicated that sampling variability ranged from 2% for pure n-heptane to 12% for a component within a ten-VOC mixture. Notably, sample variability increased with lower concentration levels and in mixtures compared to single-component atmospheres. This study provides a foundational reference for future experiments focused on atmosphere sampling performance at lower concentrations and in mixed VOC environments.<br>
description: Data downloaded: 5/20/2025