cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14805808.v1
title: Curcumin restrains hepatocellular carcinoma progression depending on the regulation of the circ_0078710/miR-378b/PRIM2 axis

description: Curcumin has shown anti-tumor activity in multiple malignancies. The aim of our study was to explore the molecular mechanism behind the anti-tumor activity of curcumin in hepatocellular carcinoma (HCC). The proliferation, migration, invasion, and apoptosis were analyzed by 5-ethynyl-2′-deoxyuridine (EDU) assay, transwell migration assay, transwell invasion assay, and flow cytometry. Western blot assay and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were conducted to analyze protein and RNA expression. Dual-luciferase reporter assay, RNA immunoprecipitation (RIP) assay, and RNA-pull down assay were performed to confirm the interaction between microRNA-378b (miR-378b) and circular RNA_0078710 (circ_0078710) or DNA primase, polypeptide 2 (PRIM2). Tumor xenograft assay was conducted to assess the roles of curcumin and circ_0078710 <i>in vivo</i>. Curcumin stimulation restrained the proliferation, migration, and invasion, and triggered the apoptosis of HCC cells. Curcumin down-regulated the expression of circ_0078710 in HCC cells in a dose-dependent manner. Circ_0078710 knockdown aggravated curcumin-mediated anti-tumor effects in HCC cells. Circ_0078710 acted as a molecular sponge for miR-378b. Circ_0078710 interference-induced effects in curcumin-stimulated HCC cells were partly abolished by the silence of miR-378b. MiR-378b bound to the 3′ untranslated region (3′UTR) of PRIM2. PRIM2 overexpression partly reversed circ_0078710 interference-mediated influences in curcumin-treated HCC cells. Circ_0078710 silencing aggravated curcumin-mediated suppressive effect in tumor growth <i>in vivo</i>. Circ_0078710 silencing aggravated curcumin-mediated anti-tumor effects through mediating the miR-378b/PRIM2 signaling in HCC cells.
DOI: 10.6084/m9.figshare.7465961
title: Additional file 1: of Comparative genomic analysis revealed rapid differentiation in the pathogenicity-related gene repertoires between Pyricularia oryzae and Pyricularia penniseti isolated from a Pennisetum grass

description: Figure S1. Gene copy numbers of CAZymes in Botrytis cinereal, Colletotrichum gloeosporioides, Fusarium graminearum, Neurospora crassa, Sclerotinia sclerotiorum, Trichoderma reesei and Ustilago maydis as well as Pyricularia isolates collected from O. sativa (PoOs), T. aestivum (PoTa), D. sanguinalis (PgDs), S. viridis (PoSv), and E. indica (PoEi). Log2 Copy Number presents variation of copy number with increased red color means increased number of CAZymes. (XLSX 20 kb)
DOI: 10.6084/m9.figshare.13233003.v1
title: Additional file 2 of DeepciRGO: functional prediction of circular RNAs through hierarchical deep neural networks using heterogeneous network features

description: The biological process (BP)functions and case studies of circRNAs predicted by DeepciRGO.
DOI: 10.6084/m9.figshare.7465970
title: Additional file 3: of Comparative genomic analysis revealed rapid differentiation in the pathogenicity-related gene repertoires between Pyricularia oryzae and Pyricularia penniseti isolated from a Pennisetum grass

description: Table S2. P1609_vs_7015_unique_secreted. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.7465976.v1
title: Additional file 4: of Comparative genomic analysis revealed rapid differentiation in the pathogenicity-related gene repertoires between Pyricularia oryzae and Pyricularia penniseti isolated from a Pennisetum grass

description: Table S3. 70â 15 VS P1609 unique secreted proteins. (XLSX 71 kb)
DOI: 10.6084/m9.figshare.17427463
title: Cenozoic rifting and inversion of Beibuwan Basin and its linkage with the strike-slip movement along the Ailao Shan-Red River Shear Zone

description: The Cenozoic Beibuwan Basin is located along the eastern margin of the Ailao Shan Red River Shear Zone (ASRRSZ). The rifting and inversion processes of this basin provide important clues to the mechanism by which extrusion tectonics drive continental rifting and inversion development. However, the rifting and inversion of this basin remain ambiguous. Here, we employ seismic data, information about the time and displacement of faulting, syn-rift fault and isopach maps to analyse the Cenozoic rifting and inversion of Beibuwan Basin. Our results demonstrate that three stages of rifting and inversion occurred in this basin: (1) During the Palaeocene initial rifting, a series of NE-striking isolated half-grabens formed, which indicated that NW-SE extension dominated in this basin, and the southward slab-pull of Proto-South China Sea (SCS) was the likely cause of the extension. (2) During the Eocene rifting stage, besides significant motion on NE-striking faults, a small number of E-striking faults started to become active, which indicates that the extensional stress field shifted from NW-SE to N-S. (3) During the Oligocene rifting stage, the E-striking faults intensified, and controlled the distribution of the sediment depocentres, which implies that N-S extension dominated the deformation during this stage. The left-lateral strike-slip movement of the ASRRSZ and the slab-pull of the Proto-SCS are suggested to explain the extension stress field shift from NW-SE to N-S during the Eocene to Oligocene. (4) End-Oligocene, end-Miocene and end-Pliocene inversions have been recognized in this basin. The regional end-Oligocene inversion was stronger in the western area than the eastern area of the basin, which suggests that the compression caused by the left-lateral shearing of the ASRRSZ gradually decreased towards the east. In addition, the localized end-Miocene and end-Pliocene inversions occurred in the Haizhong sag.
DOI: 10.6084/m9.figshare.7465988.v1
title: MOESM12 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 12. VIF of selected environmental factors by the functions of envfit (permuâ =â 999) and vif.cca among the quadriplegia and paraplegic SCI groups.
DOI: 10.6084/m9.figshare.7465997
title: MOESM13 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 13. RDA/CCA showed that GLU, HDL, CR significantly affected bacterial composition in phylum level between quadriplegia and paraplegic SCI groups.
DOI: 10.6084/m9.figshare.7465865.v1
title: Additional file 1: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: Primers used for PCR and qRT-PCR. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7465997.v1
title: MOESM13 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 13. RDA/CCA showed that GLU, HDL, CR significantly affected bacterial composition in phylum level between quadriplegia and paraplegic SCI groups.
DOI: 10.6084/m9.figshare.7466000
title: MOESM14 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 14. RDA/CCA showed that HD, CR significantly affected bacterial composition in genus level between quadriplegia and paraplegic SCI groups.
DOI: 10.6084/m9.figshare.7466012.v1
title: MOESM16 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 16. Correlation heatmap analysis chart of different environmental factors on the community composition of quadriplegia and paraplegic SCI groups in genus level.
DOI: 10.6084/m9.figshare.13233003
title: Additional file 2 of DeepciRGO: functional prediction of circular RNAs through hierarchical deep neural networks using heterogeneous network features

description: The biological process (BP)functions and case studies of circRNAs predicted by DeepciRGO.
DOI: 10.6084/m9.figshare.7465904.v1
title: Additional file 6: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: The potential miRNA-target interactions which may play a vital role in muscle growth of the H. discus hannai. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.7466045
title: MOESM3 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 3. VIF of selected environmental factors by the functions of envfit (permuâ =â 999) and vif.cca among the healthy male and SCI groups.
DOI: 10.6084/m9.figshare.14281778.v1
title: Insulin Use and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery

description: Abstract Objective: To describe insulin use and postoperative glucose control in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: We examined 2,390 patients with and without diabetes enrolled in the Contemporary Analysis of Perioperative Cardiovascular Surgical Care (CAPS-Care) Study who underwent CABG surgery (01/2004 - 06/2005) to describe postoperative insulin use, variation in insulin use across different hospitals, and associated in-hospital complications and clinical outcomes. Logistic regression was used to assess the adjusted relationship between insulin use and clinical outcomes. Results: Overall, insulin was used in 82% (n=1,959) of patients, including 95% (n=1,203) with diabetes (n=1,258) and 67% (n=756) without diabetes (n=1,132). Continuous insulin was used in 35.5% of patients in the operating room and in 56% in the intensive care unit. Continuous insulin use varied significantly among centers from 8-100% in patients with diabetes. When compared with all patients not receiving insulin, insulin use in patients without diabetes was associated with a higher rate of death or major complication (adjusted odds ratio [OR]=1.54; 95% confidence interval [CI] 1.15-2.04; P=0.003). In patients with diabetes, insulin use was not associated with a higher risk of adverse outcomes (adjusted OR=1.01; 95% CI 0.52-1.98; P=0.98). Conclusion: The postoperative use of insulin is high among CABG patients in the United States of America. Insulin use in patients without diabetes was associated with worse clinical outcomes compared to patients (both with and without diabetes) who did not receive insulin. Further investigation is needed to determine the optimal use of postoperative insulin after CABG.
DOI: 10.6084/m9.figshare.7465871
title: Additional file 2: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: Small RNA sequencing Data. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.14281676.v1
title: Two Cases Treated by Different Strategies for Common Carotid Artery Dissection with Thrombosis Due to a Type A Aortic Dissection

description: Abstract Total arch replacement and stent trunk were performed for two patients. One of these underwent a total bilateral carotid artery replacement in anatomical position while the other underwent partial carotid artery dissection. The first patient demonstrated no neurological complication after surgery and a postoperative computed tomography angiography (CTA) showed bilateral common carotid artery patency. However, the second patient had neurological dysfunction after surgery, while a postoperative CTA showed occlusion of the left common carotid artery. Anatomical replacement for a common carotid artery dissection with thrombus has the potential to significantly improve cerebral perfusion and reduce postoperative neurological complications.
DOI: 10.5258/soton/d2936
title: Dataset in support of the University of Southampton Doctoral Thesis 'Understanding and improving the mechanisms of action of anti-GD2 monoclonal antibody therapy in neuroblastoma'.

description: Dataset in support of the University of Southampton Doctoral Thesis 'Understanding and improving the mechanisms of action of anti-GD2 monoclonal antibody therapy in neuroblastoma'

This dataset contains experimental data collected from the CCI (University of Southampton) or NDCN (University of Oxford) laboratory. These datasets were collected and calculated by the researcher and analysed using GraphPad Prism Software. Biochemical, in vitro and in vivo experimental protocols were utilised to generate the data.

The data is presented in excel file.
DOI: 10.24403/jp.1330400
title: Kreeb, K. H.: Methoden zur Pflanzenökologie und Bioindikation. - Jena : Gustav Fischer Verlag, 1990 / [rezensiert von] H. Manitz
DOI: 10.6084/m9.figshare.7465889
title: Additional file 4: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: The information of known miRNAs and novel miRNAs. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.7465856
title: Additional file 1: of Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats

description: Table S1. Raw data of relative PKC activity. Table S2. Raw data of Western blotting detection of SK2 expression. Table S3. Raw data of Western blotting detection of SK3 expression. Table S4 Raw data of Western blotting detection of pERK expression. Table S5. Raw data of mean optical density values of SK2 expression. Table S6. Raw data of mean optical density values of SK3 expression. (ZIP 25 kb)
DOI: 10.6084/m9.figshare.14281652.v1
title: Comparative Study between Surgical Repair of Atrial Septal Defect via Median Sternotomy, Right Submammary Thoracotomy, and Right Vertical Infra-Axillary Thoracotomy

description: Abstract Objective: To compare the results of surgical repair via median sternotomy, right submammary thoracotomy, and right vertical infra-axillary thoracotomy for atrial septal defect (ASD). Methods: This is a retrospective analysis of the relative perioperative and postoperative data of 136 patients who underwent surgical repair for ASD with the abovementioned three different treatments in our hospital from June 2014 to December 2017. Results: The results of the surgeries were all satisfactory in the three groups. No statistically significant difference was found in operative time, duration of cardiopulmonary bypass, blood transfusion amount, postoperative mechanical ventilation time, duration of intensive care unit, length of hospital stay, and hospital costs. However, the median sternotomy group had the longest incision. Meanwhile, there was no significant difference in postoperative complications. Conclusion: All three types of surgical incisions can be safely and effectively used to repair ASD. The treatments via right submammary thoracotomy and right vertical infra-axillary thoracotomy have advantages over the treatment via median sternotomy in cosmetic results and should be the recommended options.
DOI: 10.6084/m9.figshare.7465871.v1
title: Additional file 2: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: Small RNA sequencing Data. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7465883.v1
title: Additional file 3: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: Genomic location information of Small RNA. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7465898
title: Additional file 5: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: The conserved miRNAs across the different animal species in the miRBase. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.14281652
title: Comparative Study between Surgical Repair of Atrial Septal Defect via Median Sternotomy, Right Submammary Thoracotomy, and Right Vertical Infra-Axillary Thoracotomy

description: Abstract Objective: To compare the results of surgical repair via median sternotomy, right submammary thoracotomy, and right vertical infra-axillary thoracotomy for atrial septal defect (ASD). Methods: This is a retrospective analysis of the relative perioperative and postoperative data of 136 patients who underwent surgical repair for ASD with the abovementioned three different treatments in our hospital from June 2014 to December 2017. Results: The results of the surgeries were all satisfactory in the three groups. No statistically significant difference was found in operative time, duration of cardiopulmonary bypass, blood transfusion amount, postoperative mechanical ventilation time, duration of intensive care unit, length of hospital stay, and hospital costs. However, the median sternotomy group had the longest incision. Meanwhile, there was no significant difference in postoperative complications. Conclusion: All three types of surgical incisions can be safely and effectively used to repair ASD. The treatments via right submammary thoracotomy and right vertical infra-axillary thoracotomy have advantages over the treatment via median sternotomy in cosmetic results and should be the recommended options.
DOI: 10.6084/m9.figshare.7465850.v1
title: Additional file 2: of Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota

description: Operational taxonomic units (OTUs) and taxonomy of fecal microbiota. (XLSX 113â kb)
DOI: 10.6084/m9.figshare.7466057
title: MOESM4 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 4. RDA/CCA showed that GLU, HDL, CR significantly affected bacterial composition in phylum level between the healthy male and SCI groups.
DOI: 10.6084/m9.figshare.14281688.v1
title: Transcatheter aortic valve implantation versus surgical aortic valve replacement for treatment of severe aortic stenosis: comparison of results from randomized controlled trials and real-world data

description: Abstract Objective: Results from randomized controlled trials (RCTs) and real-world study (RWS) appear to be discordant. We aimed to investigate whether data derived from RCTs and RWS evaluating long-term all-cause mortality of transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis (AS) were in agreement. Methods: RCTs or RWS comparing TAVI and SAVR, reporting longterm (≥2-year follow-up) all-cause mortality, were identified. We also carried out subgroup analyses to access the effect in different subgroups. A pre-designated data extraction form including 5 domains and 26 items was used to explore the relationship between RCTs and RWS. Mortality and effect in different subgroups were evaluated using random-effects meta-analyses. Results: Five RCTs (5421 participants, TAVI: 2759, SAVR: 2662) and 33 RWS (20839 participants; TAVI: 6585, SAVR: 14254) were identified. Pooled RCT analysis showed no difference in all-cause mortality between TAVI and SAVR (HR=0.97, 95% CI: 0.88-1.07; P=0.55). In RWS, TAVI was associated with an increased risk of allcause mortality (HR=1.46, 95% CI: 1.26-1.69; P&lt;0.001) compared to SAVR. Conclusion: These results highlight the inconsistencies between RCTs and RWS in assessing long-term all-cause mortality in the treatment of AS using TAVI or SAVR, which may be caused by interactions of clinical characteristics or study design. RCTs as well as RWS are both developing and improving; the advantages of one kind of design, measurement and evaluation can and should be thoughtfully referred to the other.
DOI: 10.6084/m9.figshare.7466057.v1
title: MOESM4 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 4. RDA/CCA showed that GLU, HDL, CR significantly affected bacterial composition in phylum level between the healthy male and SCI groups.
DOI: 10.6084/m9.figshare.14281676
title: Two Cases Treated by Different Strategies for Common Carotid Artery Dissection with Thrombosis Due to a Type A Aortic Dissection

description: Abstract Total arch replacement and stent trunk were performed for two patients. One of these underwent a total bilateral carotid artery replacement in anatomical position while the other underwent partial carotid artery dissection. The first patient demonstrated no neurological complication after surgery and a postoperative computed tomography angiography (CTA) showed bilateral common carotid artery patency. However, the second patient had neurological dysfunction after surgery, while a postoperative CTA showed occlusion of the left common carotid artery. Anatomical replacement for a common carotid artery dissection with thrombus has the potential to significantly improve cerebral perfusion and reduce postoperative neurological complications.
DOI: 10.6084/m9.figshare.7465889.v1
title: Additional file 4: of Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai

description: The information of known miRNAs and novel miRNAs. (XLSX 18 kb)
DOI: 10.24403/jp.1330401
title: Martensen, H. O. & Probst, W.: Farn- und Samenpflanzen in Europa. - Stuttgart ; New York : Gustav Fischer Verlag, 1990 / [rezensiert von] H.-J. Zündorf
DOI: 10.6084/m9.figshare.22662441
title: Additional file 2 of Optimizing yeast for high-level production of kaempferol and quercetin

description: Additional file 2: Feeding profile for glucose limited fed-batch fermentation of kaempferol and quercetin.
DOI: 10.6084/m9.figshare.7466078
title: MOESM7 of Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

description: Additional file 7. Correlation heatmap analysis chart of different environmental factors on the community composition of healthy male and SCI groups in genus level.
DOI: 10.6084/m9.figshare.14281697
title: Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

description: Abstract Objective: To investigate the effect of Shenfu (SF) injection on donor heart preservation. Methods: Twelve pigs were randomly divided into SF group (n=6) and control group (n=6). After eight hours of perfusion, the differences in hemoglobin, the expression of Bcl-2 and BAX, and changes in the myocardial ultrastructure were compared to illustrate the effects of SF injection in heart preservation. Results: The differences in free hemoglobin between the SF group and the control group were statistically significant (P=0.001), and there was significant interaction of groups with times (P=0.019), but the perfusion time may not be associated with the hemoglobin concentration (P=0.616). According to Western blotting analysis, the expression of Bcl-2 was higher in the SF group than in the control group, while the expression of BAX was not different between the two groups. As to ultrastructural changes, both groups exhibited mitochondrial swelling and myofilament lysis, but the degree of damage in the SF group was smaller. Conclusion: Our study suggests that the application of SF injection for heart preservation may protect against cardiomyocytes and erythrocytes apoptosis, and Bcl-2 protein may play a role in these physiological processes.