cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20291941.v1
title: Urinary exosomes derived circRNAs as biomarkers for chronic renal fibrosis

description: Chronic renal disease (CKD) is a common and irreversible loss of renal function. Renal fibrosis reflected the degree of renal dysfunction. However, the current biomarkers only characterize the renal function instead of indicating the fibrosis degree. The potential diagnostic value of urinary exosomes derived circRNAs for renal fibrosis needs to be further studied. Urine exosomes from 3 chronic kidney disease (CKD) patients without renal fibrosis and 3 renal fibrotic patients were collected and human circRNAs microarray analysis were performed to detect the circRNAs expression profile. 110 biopsy-proven CKD patients and 54 healthy controls were enrolled and urine exosomes derived RNA was isolated. The expression of hsa_circ_0036649 was measured and the correlation with renal function parameter and pathological indicators was performed. The receiver operating characteristic (ROC) curve for the diagnosis of renal fibrosis was calculated. Human circRNAs microarray showed 365 circRNAs up expressed and 195 circRNAs down expressed in renal fibrotic patients compared to none fibrosis CKD patients. The expression of hsa_circ_0036649 was decreased in renal fibrotic patients according to RT-PCR and correlated with serum creatinine, blood urea nitrogen (BUN), estimated glomerular filtration rate and cystatin c. Further, the expression of hsa_circ_0036649 was correlated with the score of tubulointerstitial fibrosis (TIF) and the score of glomerular sclerosis. The ROC curve showed that hsa_circ_0036649 may predict renal fibrosis at a cut-off value of 0.597 with a sensitivity of 45.5% and specificity of 87.9%. Expression of urinary exosomes derived hsa_circ_0036649 associated with the degree of renal fibrosis. Its potential role as a biomarker in CKD remained to be supported by further follow-up studies.
Key MessagescircRNAs profile in urine exosomes in renal fibrosis patients was revealed.The expression of urine exosomes derived hsa_circ_0036649 was correlated to renal function and fibrosis degree.circRNAs derived from urinary exosomes may become a new research direction for biomarkers of renal fibrosis. circRNAs profile in urine exosomes in renal fibrosis patients was revealed. The expression of urine exosomes derived hsa_circ_0036649 was correlated to renal function and fibrosis degree. circRNAs derived from urinary exosomes may become a new research direction for biomarkers of renal fibrosis.
DOI: 10.6084/m9.figshare.21564424
title: Network pharmacology and <i>in vivo</i> experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis

description: Ulcerative colitis (UC), a chronic inflammatory disease, often cause carcinogenesis, disability, and intestinal perforation. The JingFangFuZiLiZhong formula (JFFZLZ) shows a good effect against UC in the clinic. Hence, we aim to investigate the mechanisms between JFFZLZ and UC <i>via</i> network pharmacology data mining and <i>in vivo</i> experiments. We obtained active constituents and related targets from public databases. The overlapped genes between JFFZLZ and UC targets were further analysed by enrichment analysis. The active constituents and hub targets were used to construct molecule docking analysis. We finally screened out nine hub targets and their expressions were verified in the Gene Expression Omnibus database and UC rats’ colon tissues after JFFZLZ treatment. The results implied that JFFZLZ mainly regulated signal transduction, metabolites production, and inflammation pathways. The expression of STAT3, CXCL8, IL6, CXCL12, TNF, TP53, and PTPN11 were both upregulated in colon tissues of UC patients and UC rats. While RELA, EGFR, and TP53 were downregulated in UC patients, but upregulated in UC rats. Furthermore, JFFZLZ could repair UC rats’ colon mucosal damage and promote the healing of ulcers <i>via</i> regulating the hub targets. These results elucidated that the anti-UC effect of JFFZLZ was closely related to the inhibition of inflammatory response, inhibition of oxidative stress, and repairing colon mucosal damage through different signal pathways. The findings could contribute to a better understanding of the regulation mechanisms in JFFZLZ against UC.Key messagesJFFZLZ could reduce the inflammatory infiltration and repair UC rats’ colon mucosal damage.Through the network pharmacology-based strategy and public database mining, we obtained the hub targets and key pathways between JFFZLF and UC.The mechanism of JFFZLZ against UC was inhibition of inflammatory response and oxidative stress by regulating the expression of the hub targets. JFFZLZ could reduce the inflammatory infiltration and repair UC rats’ colon mucosal damage. Through the network pharmacology-based strategy and public database mining, we obtained the hub targets and key pathways between JFFZLF and UC. The mechanism of JFFZLZ against UC was inhibition of inflammatory response and oxidative stress by regulating the expression of the hub targets.
DOI: 10.6084/m9.figshare.21564424.v1
title: Network pharmacology and <i>in vivo</i> experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis

description: Ulcerative colitis (UC), a chronic inflammatory disease, often cause carcinogenesis, disability, and intestinal perforation. The JingFangFuZiLiZhong formula (JFFZLZ) shows a good effect against UC in the clinic. Hence, we aim to investigate the mechanisms between JFFZLZ and UC <i>via</i> network pharmacology data mining and <i>in vivo</i> experiments. We obtained active constituents and related targets from public databases. The overlapped genes between JFFZLZ and UC targets were further analysed by enrichment analysis. The active constituents and hub targets were used to construct molecule docking analysis. We finally screened out nine hub targets and their expressions were verified in the Gene Expression Omnibus database and UC rats’ colon tissues after JFFZLZ treatment. The results implied that JFFZLZ mainly regulated signal transduction, metabolites production, and inflammation pathways. The expression of STAT3, CXCL8, IL6, CXCL12, TNF, TP53, and PTPN11 were both upregulated in colon tissues of UC patients and UC rats. While RELA, EGFR, and TP53 were downregulated in UC patients, but upregulated in UC rats. Furthermore, JFFZLZ could repair UC rats’ colon mucosal damage and promote the healing of ulcers <i>via</i> regulating the hub targets. These results elucidated that the anti-UC effect of JFFZLZ was closely related to the inhibition of inflammatory response, inhibition of oxidative stress, and repairing colon mucosal damage through different signal pathways. The findings could contribute to a better understanding of the regulation mechanisms in JFFZLZ against UC.Key messagesJFFZLZ could reduce the inflammatory infiltration and repair UC rats’ colon mucosal damage.Through the network pharmacology-based strategy and public database mining, we obtained the hub targets and key pathways between JFFZLF and UC.The mechanism of JFFZLZ against UC was inhibition of inflammatory response and oxidative stress by regulating the expression of the hub targets. JFFZLZ could reduce the inflammatory infiltration and repair UC rats’ colon mucosal damage. Through the network pharmacology-based strategy and public database mining, we obtained the hub targets and key pathways between JFFZLF and UC. The mechanism of JFFZLZ against UC was inhibition of inflammatory response and oxidative stress by regulating the expression of the hub targets.
DOI: 10.15468/dl.vpf3xw
title: Occurrence Download

description: A dataset containing 237 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Bassia hirsuta (L.) Asch.",
 "Geometry POLYGON((-30.937499 61.938950,-30.937499 27.059125,52.03125 27.059125,52.03125 61.938950,-30.937499 61.938950))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 237 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xttxet
title: Occurrence Download

description: A dataset containing 86 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Saurauia miniata C.F.Liang & Y.S.Wang"
 ]
}

 The dataset includes 86 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033344-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nragdd
title: Occurrence Download

description: A dataset containing 918 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Dioscorea schimperiana Hochst. ex Kunth"
 ]
}

 The dataset includes 918 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0052568-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ds8bku
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Hong Kong, Macao, Chinese Taipei)",
 "TaxonKey is Epinephelus areolatus (Forsskål, 1775)"
 ]
}

 The dataset includes 92 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033346-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kkmzkj
title: Occurrence Download

description: A dataset containing 3045 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vitex agnus-castus L."
 ]
}

 The dataset includes 3045 records from 158 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-150922153815467/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m89t5s
title: Occurrence Download

description: A dataset containing 88796 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Buphagidae"
 ]
}

 The dataset includes 88796 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0057424-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vsvbwz
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Berea College, Ralph L. Thompson Herbarium",
 "TaxonKey is Rudbeckia hirta L."
 ]
}

 The dataset includes 31 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060961-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z2u2cc
title: Occurrence Download

description: A dataset containing 1493 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Barisia imbricata (Wiegmann, 1828)"
 ]
}

 The dataset includes 1493 records from 54 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-151016162008034/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.66nbkh
title: Occurrence Download

description: A dataset containing 402 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Mariposas diurnas presentes en los parques urbanos de Bogotá"
 ]
}

 The dataset includes 402 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041219-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.or1nmu
title: Occurrence Download

description: A dataset containing 45779 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Zea mays L.",
 "HasGeospatialIssue is false",
 "HasCoordinate is false"
 ]
}

 The dataset includes 45779 records from 121 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-160311141623029/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rmauhr
title: Occurrence Download

description: A dataset containing 732 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Asarcornis scutulata (S.Müller, 1842)"
 ]
}

 The dataset includes 732 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0052587-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.99vuvf
title: Occurrence Download

description: A dataset containing 2383 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Redunca redunca (Pallas, 1767)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2383 records from 39 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009487-240202131308920/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vzsrlz
title: Occurrence Download

description: A dataset containing 76 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Scytalinidae"
 ]
}

 The dataset includes 76 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-160509122628363/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y2wp4m
title: Occurrence Download

description: A dataset containing 57 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Gastrochilus retrocallus (Hayata) Hayata"
 ]
}

 The dataset includes 57 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0063019-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kcmezk
title: Occurrence Download

description: A dataset containing 1032 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Greece",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Phlomis fruticosa L., Phlomis floccosa D.Don, Phlomis bourgaei Boiss.)"
 ]
}

 The dataset includes 1032 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0151038-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.76yj73
title: Occurrence Download

description: A dataset containing 2198 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vipera ursinii (Bonaparte, 1835)"
 ]
}

 The dataset includes 2198 records from 54 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0079669-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ruh3wk
title: Occurrence Download

description: A dataset containing 1002 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Schefflera vinosa (Cham. & Schltdl.) Frodin & Fiaschi"
 ]
}

 The dataset includes 1002 records from 71 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-160526112335914/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hstvu8
title: Occurrence Download

description: A dataset containing 207 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cremanthodium nobile (Franch.) Diels ex H.Lév."
 ]
}

 The dataset includes 207 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0151025-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ml81vi
title: Occurrence Download

description: A dataset containing 61354 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Salix fragilis L."
 ]
}

 The dataset includes 61354 records from 352 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-160623103540712/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c6tejq
title: Occurrence Download

description: A dataset containing 49 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Indonesia",
 "OccurrenceStatus is Present",
 "TaxonKey is Kaempferia L."
 ]
}

 The dataset includes 49 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0411783-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s2n69e
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Greece",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Phlomis bourgaei Boiss."
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0151028-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qwdzez
title: Occurrence Download

description: A dataset containing 23019 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ardea alba Linnaeus, 1758",
 "Country is Mexico"
 ]
}

 The dataset includes 23019 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005469-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xcbs2y
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sloanea uncinata T.D.Penn."
 ]
}

 The dataset includes 17 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0196813-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ftaq48
title: Occurrence Download

description: A dataset containing 46 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Emblemaria atlantica Jordan & Evermann, 1898"
 ]
}

 The dataset includes 46 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060342-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ghx1sw
title: Occurrence Download

description: A dataset containing 4919 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Brassica oleracea L.",
 "Geometry POLYGON((-30.937499 61.938950,-30.937499 27.059125,52.03125 27.059125,52.03125 61.938950,-30.937499 61.938950))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4919 records from 92 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005470-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.peagdw
title: Occurrence Download

description: A dataset containing 142 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cremanthodium oblongatum C.B.Clarke"
 ]
}

 The dataset includes 142 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0151029-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yfjfuz
title: Occurrence Download

description: A dataset containing 1439 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Year 2016-2019",
 "Geometry POLYGON((120.6032 24.54213,120.59692 24.35067,120.69109 24.41643,120.84804 24.5878,121.03638 24.83588,121.31888 25.1261,121.25924 25.16872,120.97046 25.05503,120.6032 24.54213))",
 "TaxonKey is Plantae",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1439 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0031264-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ijodhx
title: Occurrence Download

description: A dataset containing 75 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cephalocereus senilis (Haw.) Pfeiff."
 ]
}

 The dataset includes 75 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005470-150922153815467/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.p9437g
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Stelis soconuscana Solano"
 ]
}

 The dataset includes 6 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0196814-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jcmyu5
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Capricornis milneedwardsii David, 1869"
 ]
}

 The dataset includes 58 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027491-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jfsmak
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tabernaemontana chamelensis L.O.Alvarado & Lozada-Pérez"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0196815-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.