cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14724133.v1
title: Immune enhancement effects of Korean ginseng berry polysaccharides on RAW264.7 macrophages through MAPK and NF-κB signalling pathways

description: Ginseng, a commonly used medicinal herb, contains polysaccharide as one of the bioactive compounds. This study aimed at evaluating the immune enhancement effects of Korean ginseng berry polysaccharides (GBPs) on macrophage RAW264.7 cells and their chemical characteristics. The crude polysaccharide (GBP-C) was extracted and fractionated to different polysaccharides (GBP-F1, GBP-F2, and GBP-F3). GBPs were mainly composed of rhamnose, arabinose, mannose, glucose and galactose, with molecular weights (<i>M<sub>w</sub></i>) ranging from 16 × 10<sup>3</sup> to 328 × 10<sup>3</sup> g/mol. While all the GBPs significantly increased the NO production in a dose-dependent manner, GBP-F2 showed the highest immune-enhancing effects. GBP-F2 up-regulated the mRNA expression of <i>iNOS</i>, <i>IL-1β</i>, <i>IL-6</i>, <i>IL-10,</i> and <i>TNF-α</i> through activating phosphorylation of NF-κB-p65, ERK1/2, JNK, and p38 to a greater extent than the other GBPs samples. These results indicate that GBPs, and especially GBP-F2, have strong immune enhancement effects desirable for application in the food and pharmaceutical industries.
DOI: 10.6084/m9.figshare.13489201
title: Red ginseng extracts as an adjunctive therapeutic for gout: preclinical and clinical evidence

description: We investigated if Red ginseng extract (RGE) suppressed monosodium urate crystal (MSU)-induced NLRP3 activation and could be a potential therapeutic agent for gout. The effects of RGE on acute gouty inflammation were investigated using the air-pouch model. RGE significantly suppressed acute gout inflammation in the air-pouch model, based on the decreased number of WBCs in the air-pouch lavage fluid. In vitro, RGE inhibited MSU-induced IL-1β production in THP-1 cells. Twenty-four gout patients in intercritical period were randomized either to red ginseng tablet (RGT) or placebo group. The assembly of NLRP3 inflammasomes was inhibited via reduced ASC expression and oligomerization. Patients taking RGT for 3 months showed significantly reduced NLRP3 expression compared to baseline. In conclusion, RGE suppressed acute gout inflammation by suppressing NLRP3 inflammasomes in animal models. Clinically, RGT suppressed NLRP3 expression in gout patients. The data suggest that red ginseng may exert an additive benefit in gout treatment.
DOI: 10.6084/m9.figshare.13489201.v1
title: Red ginseng extracts as an adjunctive therapeutic for gout: preclinical and clinical evidence

description: We investigated if Red ginseng extract (RGE) suppressed monosodium urate crystal (MSU)-induced NLRP3 activation and could be a potential therapeutic agent for gout. The effects of RGE on acute gouty inflammation were investigated using the air-pouch model. RGE significantly suppressed acute gout inflammation in the air-pouch model, based on the decreased number of WBCs in the air-pouch lavage fluid. In vitro, RGE inhibited MSU-induced IL-1β production in THP-1 cells. Twenty-four gout patients in intercritical period were randomized either to red ginseng tablet (RGT) or placebo group. The assembly of NLRP3 inflammasomes was inhibited via reduced ASC expression and oligomerization. Patients taking RGT for 3 months showed significantly reduced NLRP3 expression compared to baseline. In conclusion, RGE suppressed acute gout inflammation by suppressing NLRP3 inflammasomes in animal models. Clinically, RGT suppressed NLRP3 expression in gout patients. The data suggest that red ginseng may exert an additive benefit in gout treatment.
DOI: 10.6084/m9.figshare.17702364.v1
title: Sensitive CG-ICA based on heterologous coating antigen and mAb prepared with carbons-linker immunogen

description: Amantadine (AMD) is harmful to human health and has been forbidden as an antiviral drug in the livestock and poultry breeding. Thus, a rapid and sensitive detection method for AMD should be established. In this research, we have designed three kinds of haptens and then prepared three kinds of immunogens and coating antigens. A highly sensitive colloidal gold immunochromatographic assay (CG-ICA) for AMD detection by using heterologous coating antigen and mAb prepared with immunogen adding five carbons linker has been established. Under optimal conditions, the cut-off value of the CG-ICA was 2.5 ng/mL by naked eyes. The CG-ICA presented a good signal response to AMD in the concentration range of 0.1–2.5 ng/mL with low LOD at 0.077 ng/mL. These results indicated that the immunogen with carbon linker may obtain high-affinity antibody while the heterologous coating antigen may improve the sensitivity of ICA.
DOI: 10.6084/m9.figshare.17702367.v1
title: Stimulation of humoral and cell-mediated immunities in healthy and cyclophosphamide-induced immunosuppressed rats by the lyophilized <i>Houttuynia cordata</i> fermented drink

description: <i>Houttuynia cordata</i> fermented drinks (HCFDs) are dietary liquid supplements widely marketed and consumed for immune enhancement. In this study, the acute oral toxicity and immunostimulatory activity of the selected lyophilized HCFD in healthy and cyclophosphamide-induced immunosuppressed rats were evaluated. The lyophilized selected commercialized HCFD was safe in animal model as there was no acute oral toxic death at up to 2000 mg/kg in male Wistar rats. After 14 days of treatment, in immunosuppressed rats, lyophilized HCFD enhanced rat body weight gain and significantly increased spleen index at a dose of 100 mg/kg. Moreover, B-cell proliferation and anti-sheep red blood cell antibody production were significantly increased at doses of 100 and 200 mg/kg, respectively. The delayed-type hypersensitivity response was significantly stimulated at a dose of 200 mg/kg. These findings exhibited the immunostimulatory activity of the lyophilized HCFD by enhancing the immune responses in both humoral and cell-mediated immunities in immunosuppressed rats.
DOI: 10.6084/m9.figshare.14724133
title: Immune enhancement effects of Korean ginseng berry polysaccharides on RAW264.7 macrophages through MAPK and NF-κB signalling pathways

description: Ginseng, a commonly used medicinal herb, contains polysaccharide as one of the bioactive compounds. This study aimed at evaluating the immune enhancement effects of Korean ginseng berry polysaccharides (GBPs) on macrophage RAW264.7 cells and their chemical characteristics. The crude polysaccharide (GBP-C) was extracted and fractionated to different polysaccharides (GBP-F1, GBP-F2, and GBP-F3). GBPs were mainly composed of rhamnose, arabinose, mannose, glucose and galactose, with molecular weights (<i>M<sub>w</sub></i>) ranging from 16 × 10<sup>3</sup> to 328 × 10<sup>3</sup> g/mol. While all the GBPs significantly increased the NO production in a dose-dependent manner, GBP-F2 showed the highest immune-enhancing effects. GBP-F2 up-regulated the mRNA expression of <i>iNOS</i>, <i>IL-1β</i>, <i>IL-6</i>, <i>IL-10,</i> and <i>TNF-α</i> through activating phosphorylation of NF-κB-p65, ERK1/2, JNK, and p38 to a greater extent than the other GBPs samples. These results indicate that GBPs, and especially GBP-F2, have strong immune enhancement effects desirable for application in the food and pharmaceutical industries.
DOI: 10.6084/m9.figshare.17702367
title: Stimulation of humoral and cell-mediated immunities in healthy and cyclophosphamide-induced immunosuppressed rats by the lyophilized <i>Houttuynia cordata</i> fermented drink

description: <i>Houttuynia cordata</i> fermented drinks (HCFDs) are dietary liquid supplements widely marketed and consumed for immune enhancement. In this study, the acute oral toxicity and immunostimulatory activity of the selected lyophilized HCFD in healthy and cyclophosphamide-induced immunosuppressed rats were evaluated. The lyophilized selected commercialized HCFD was safe in animal model as there was no acute oral toxic death at up to 2000 mg/kg in male Wistar rats. After 14 days of treatment, in immunosuppressed rats, lyophilized HCFD enhanced rat body weight gain and significantly increased spleen index at a dose of 100 mg/kg. Moreover, B-cell proliferation and anti-sheep red blood cell antibody production were significantly increased at doses of 100 and 200 mg/kg, respectively. The delayed-type hypersensitivity response was significantly stimulated at a dose of 200 mg/kg. These findings exhibited the immunostimulatory activity of the lyophilized HCFD by enhancing the immune responses in both humoral and cell-mediated immunities in immunosuppressed rats.
DOI: 10.6084/m9.figshare.17702364
title: Sensitive CG-ICA based on heterologous coating antigen and mAb prepared with carbons-linker immunogen

description: Amantadine (AMD) is harmful to human health and has been forbidden as an antiviral drug in the livestock and poultry breeding. Thus, a rapid and sensitive detection method for AMD should be established. In this research, we have designed three kinds of haptens and then prepared three kinds of immunogens and coating antigens. A highly sensitive colloidal gold immunochromatographic assay (CG-ICA) for AMD detection by using heterologous coating antigen and mAb prepared with immunogen adding five carbons linker has been established. Under optimal conditions, the cut-off value of the CG-ICA was 2.5 ng/mL by naked eyes. The CG-ICA presented a good signal response to AMD in the concentration range of 0.1–2.5 ng/mL with low LOD at 0.077 ng/mL. These results indicated that the immunogen with carbon linker may obtain high-affinity antibody while the heterologous coating antigen may improve the sensitivity of ICA.
DOI: 10.34740/kaggle/dsv/3164712
title: Contrastive Language Image Pretraining by openai
DOI: 10.5281/zenodo.6032398
title: Dataset of Issues

description: This repository contains the datasets used in the study and the scripts used to collect them.
DOI: 10.6084/m9.figshare.18142718.v6
title: gene

description: Transcriptomics was employed to analyze and compare gene expression levels of different groups. It showed that the expressions of genes (Cyp1a1, Noct, and TUBB6) related to liver injury were regulated by SBS.
DOI: 10.5281/zenodo.6032447
title: Dataset of Issues

description: This repository contains the datasets used in the study and the scripts used to collect them. dataset -
DOI: 10.5281/zenodo.6032397
title: Dataset of Issues

description: This repository contains the datasets used in the study and the scripts used to collect them. dataset -
DOI: 10.6084/m9.figshare.19152497.v1
title: 12 tet(X4)-positive strains from pigs

description: WGS data of 12 tet(X4)-positive strains
DOI: 10.6084/m9.figshare.19152497
title: strains from pigs

description: WGS数据
DOI: 10.6084/m9.figshare.19152497.v3
title: strains from pigs

description: WGS数据
DOI: 10.6084/m9.figshare.19152497.v2
title: 12 tet(X4)-positive strains from pigs

description: WGS data of 12 tet(X4)-positive strains
DOI: 10.6084/m9.figshare.19145126.v1
title: Raw data matrix

description: Raw data matrix that served as the analysis dataset.
DOI: 10.5281/zenodo.5229867
title: Global atmospheric soluble iron deposition

description: This dataset contains the modeled atmospheric total/soluble iron deposition on a global scale for the present-day and future conditions. The relative contributions from anthropogenic, biomass burning, and dust sources have been resolved in the data. It can be used for the modeling of ocean biogeochemistry.
DOI: 10.5281/zenodo.5229866
title: Global atmospheric soluble iron deposition

description: This dataset contains the modeled atmospheric total/soluble iron deposition on a global scale for the present-day and future conditions. The relative contributions from anthropogenic, biomass burning, and dust sources have been resolved in the data. It can be used for the modeling of ocean biogeochemistry.
DOI: 10.5281/zenodo.6004534
title: The height-dependent delayed ionospheric response to solar EUV - data comparison - secondary files 117 - 122

description: <strong>Secondary files for doy 117 - 122</strong> For comparison with the observational results a TIE-GCM v2.0 model run in the 2.5 × 2.5 configuration is calculated. In order to converge to stable initial condition the model runs for 30 days prior to the final simulation starting at 28 March 2019. This initial run is configured with default parameters. The final run from 27 April 2019 to 24 May 2019 uses the default configuration of TIE-GCM with the Heelis Electric Convection Field Model (Heelis et al., 1982) as the high-latitude potential model. The input forcing is used from the NASA/GSFC’s OMNI data set
DOI: 10.5281/zenodo.6004533
title: The height-dependent delayed ionospheric response to solar EUV - data comparison - secondary files 117 - 122

description: <strong>Secondary files for doy 117 - 122</strong> For comparison with the observational results a TIE-GCM v2.0 model run in the 2.5 × 2.5 configuration is calculated. In order to converge to stable initial condition the model runs for 30 days prior to the final simulation starting at 28 March 2019. This initial run is configured with default parameters. The final run from 27 April 2019 to 24 May 2019 uses the default configuration of TIE-GCM with the Heelis Electric Convection Field Model (Heelis et al., 1982) as the high-latitude potential model. The input forcing is used from the NASA/GSFC’s OMNI data set
DOI: 10.5281/zenodo.6009777
title: The height-dependent delayed ionospheric response to solar EUV - data comparison - secondary files 129 - 134

description: <strong>Secondary files for doy 129 - 134</strong> For comparison with the observational results a TIE-GCM v2.0 model run in the 2.5 × 2.5 configuration is calculated. In order to converge to stable initial condition the model runs for 30 days prior to the final simulation starting at 28 March 2019. This initial run is configured with default parameters. The final run from 27 April 2019 to 24 May 2019 uses the default configuration of TIE-GCM with the Heelis Electric Convection Field Model (Heelis et al., 1982) as the high-latitude potential model. The input forcing is used from the NASA/GSFC’s OMNI data set
DOI: 10.5281/zenodo.6009776
title: The height-dependent delayed ionospheric response to solar EUV - data comparison - secondary files 129 - 134

description: <strong>Secondary files for doy 129 - 134</strong> For comparison with the observational results a TIE-GCM v2.0 model run in the 2.5 × 2.5 configuration is calculated. In order to converge to stable initial condition the model runs for 30 days prior to the final simulation starting at 28 March 2019. This initial run is configured with default parameters. The final run from 27 April 2019 to 24 May 2019 uses the default configuration of TIE-GCM with the Heelis Electric Convection Field Model (Heelis et al., 1982) as the high-latitude potential model. The input forcing is used from the NASA/GSFC’s OMNI data set
DOI: 10.6084/m9.figshare.19119770.v2
title: GBS sample data

description: A random subset (25M reads per file) of an existing real dataset. The dataset comprises Genotyping by Sequencing (GBS) data for 34 sheep from a high and a low selection line. The GBS library was created using a <i>Pst</i>I-<i>Msp</i>I double-digest followed by a size selection step. The dataset comprises several trios (dam, sire, progeny).Also provided are a set of bash, R, python helper scripts to go from fastq files to allelic depth information and arrive at a genomic relationship matrix.<br>Any data shared here is without warranty of any kind and in no event shall the authors or copyright holders be liable for any claim, damages or any liability.<br><br>
DOI: 10.5281/zenodo.5996768
title: HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut Microbiota.

description: We reported 102 complete metagenome assembled genomes (cMAGs) from five human fecal HiFi sequencing samples. 102_cMAGs_fna.tar.gz: Fasta sequence files of 102 cMAGs. gc_skew_figures.tar.gz: GC-skew pattern figures of 102 cMAGs. (SVG format) coverage_plots.tar.gz: Genome coverage plot of 102 cMAGs.
DOI: 10.5281/zenodo.5996767
title: HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut Microbiota.

description: We reported 102 complete metagenome assembled genomes (cMAGs) from five human fecal HiFi sequencing samples. 102_cMAGs_fna.tar.gz: Fasta sequence files of 102 cMAGs. gc_skew_figures.tar.gz: GC-skew pattern figures of 102 cMAGs. (SVG format) coverage_plots.tar.gz: Genome coverage plot of 102 cMAGs.
DOI: 10.5281/zenodo.5937700
title: The height-dependent delayed ionospheric response to solar EUV - data comparison

description: For comparison with the observational results a TIE-GCM v2.0 model run in the 2.5 × 2.5 configuration is calculated. In order to converge to stable initial condition the model runs for 30 days prior to the final simulation starting at 28 March 2019. This initial run is configured with default parameters. The final run from 27 April 2019 to 24 May 2019 uses the default configuration of TIE-GCM with the Heelis Electric Convection Field Model (Heelis et al., 1982) as the high-latitude potential model. The input forcing is used from the NASA/GSFC’s OMNI data set Secondary files: 117 - 122: https://zenodo.org/record/6004534 123 - 128: https://zenodo.org/record/6006516 129 - 134: https://zenodo.org/record/6009777 135 - 140: https://zenodo.org/record/6014195 141 - 143: https://zenodo.org/record/6014201
DOI: 10.5281/zenodo.5937699
title: The height-dependent delayed ionospheric response to solar EUV - data comparison

description: For comparison with the observational results a TIE-GCM v2.0 model run in the 2.5 × 2.5 configuration is calculated. In order to converge to stable initial condition the model runs for 30 days prior to the final simulation starting at 28 March 2019. This initial run is configured with default parameters. The final run from 27 April 2019 to 24 May 2019 uses the default configuration of TIE-GCM with the Heelis Electric Convection Field Model (Heelis et al., 1982) as the high-latitude potential model. The input forcing is used from the NASA/GSFC’s OMNI data set Secondary files: 117 - 122: https://zenodo.org/record/6004534 123 - 128: https://zenodo.org/record/6006516 129 - 134: https://zenodo.org/record/6009777 135 - 140: https://zenodo.org/record/6014195 141 - 143: https://zenodo.org/record/6014201
DOI: 10.17043/reghellin-2022-sediment-1
title: Carbonate content, carbon and oxygen stable isotopes of bulk sediment from the eastern equatorial Pacific
DOI: 10.5281/zenodo.6025022
title: Dataset related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"

description: This record contains data related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions" Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+ Vδ2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of Vδ2 T cells to exert the highest effector functions even against HLA-E+ tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.
DOI: 10.5281/zenodo.6025021
title: Dataset related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"

description: This record contains data related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions" Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+ Vδ2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of Vδ2 T cells to exert the highest effector functions even against HLA-E+ tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.
DOI: 10.5517/ccdc.csd.cc28v32b
title: CCDC 2110451: Experimental Crystal Structure Determination

description: Related Article: Shuo Wang, Atsushi Kaga, Takashi Kurogi, Hideki Yorimitsu|2022|Org.Lett.|24|1105|doi:10.1021/acs.orglett.2c00084
DOI: 10.5517/ccdc.csd.cc28vwqr
title: CCDC 2111215: Experimental Crystal Structure Determination

description: Related Article: Nguyen Hung Huy|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28wrmk
title: CCDC 2112049: Experimental Crystal Structure Determination

description: Related Article: Dong Xia, Xin-Fang Duan|2021|Chem.Commun.|57|13570|doi:10.1039/D1CC06204B
description: Related Article: xia dong|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc28xtxy
title: CCDC 2113081: Experimental Crystal Structure Determination

description: Related Article: Sehee Im, Chan Hee Ryu, Mingi Kim, Dong Kyun You, Sanghee Yi, Wonchul Lee, Kang Mun Lee|2022|Inorg.Chem.Front.|9|501|doi:10.1039/D1QI01405F
DOI: 10.5517/ccdc.csd.cc28xtyz
title: CCDC 2113082: Experimental Crystal Structure Determination

description: Related Article: Sehee Im, Chan Hee Ryu, Mingi Kim, Dong Kyun You, Sanghee Yi, Wonchul Lee, Kang Mun Lee|2022|Inorg.Chem.Front.|9|501|doi:10.1039/D1QI01405F
DOI: 10.5517/ccdc.csd.cc28xv02
title: CCDC 2113084: Experimental Crystal Structure Determination

description: Related Article: Sehee Im, Chan Hee Ryu, Mingi Kim, Dong Kyun You, Sanghee Yi, Wonchul Lee, Kang Mun Lee|2022|Inorg.Chem.Front.|9|501|doi:10.1039/D1QI01405F