DOI: 10.7910/dvn/nslxc4
title: IMAGINE Fetal Diffusion Tensor MRI Atlas

description: # Fetal DWI Atlas&lt;br /&gt; &lt;br /&gt;

## UPDATE 2/12/26:&lt;br /&gt;
A higher fidelity version created using the same set of original subjects has generated. We have also added tissue and regional segmentations. Weeks 23-35 have been carefully edited for accuracy. Weeks 36-38 were created using multi-atlas segmentation and may have errors.&lt;br /&gt; &lt;br /&gt;

This version of the atlas has been moved to approximately overlay in the same space as the CRL2017 T2 Fetal Atlas. The modalities did not use the same set of subject scans and differences in processing pipelines and spatial distortions due to imaging modality may have contributed to different relative sizes of the atlas brains. Compared to earlier versions, both atlases now also share the same directional signs, though total image size and spacing still differ.&lt;br /&gt;&lt;br /&gt;

## UPDATE 2/2/23:&lt;br /&gt;
Tensor files have been added for each gestational age week.&lt;br /&gt;&lt;br /&gt;

## Contents&lt;br /&gt;

CRL 2019 Fetal Diffusion-Weighted Imaging (DWI) Atlas. This includes fractional anisotropy (FA), color fractional anisotropy (CFA), and Mean Diffusivity (MD) maps generated from in-utero DWI data of normative fetuses 23 to 38 weeks gestational age (GA). Each atlas image was composed from multiple subjects at that gestational age or +/- one week GA.

File suffixes:&lt;br /&gt;
_tensor - Reconstructed tensor image&lt;br /&gt;
Diffusion scalar images derived from tensor:&lt;br /&gt;
 _fa - Franctional anisotropy&lt;br /&gt;
 _cfa - Color FA&lt;br /&gt;
 _md - Mean diffusivity&lt;br /&gt;
_tissue - Tissue segmentation&lt;br /&gt;
_regional - Regional segmentation&lt;br /&gt;&lt;br /&gt;

DWIAtlas_labelkey.txt - ITK-SNAP label key for Tissue and Regional segmentations &lt;br /&gt;&lt;br /&gt;

Please contact us if there are any issues downloading the atlas images.
fetalmri@crl.med.harvard.edu


1. S Khan, L Vasung, B Marami, CK Rollins, O Afacan, C Ortinau, E Yang, SK Warfield, and A Gholipour. Fetal Brain Growth Portrayed by a Spatiotemporal Diffusion Tensor MRI Atlas Computed From In Utero Images. NeuroImage 2019.&lt;br /&gt;&lt;br /&gt;

2. S Khan, CK Rollins, C Ortinau, O Afacan, SK Warfield, and A Gholipour. Tract-Specific Group Analysis in Fetal Cohorts using in utero Diffusion Tensor Imaging. MICCAI 2018. [upcoming]&lt;br /&gt;&lt;br /&gt;

## License/Data Use Agreement&lt;br /&gt;
These files are published under CC BY 4.0: https://creativecommons.org/licenses/by/4.0/&lt;br /&gt;&lt;br /&gt;

Files in this data release were developed for research purposes and are not intended for medical or diagnostic use and have no warranty. The authors and distributors do not make any guarantees regarding the accuracy or usefulness of results generated from these tools or their derivatives, and are not liable for any damages resulting from their use.&lt;br /&gt;&lt;br /&gt;

Through this data use agreement, you agree to cite the DOI referring to this resource as well as the following work:&lt;br /&gt;
Khan, S., Vasung, L., Marami, B., Rollins, C.K., Afacan, O., Ortinau, C.M., Yang, E., Warfield, S.K. and Gholipour, A., 2019. Fetal brain growth portrayed by a spatiotemporal diffusion tensor MRI atlas computed from in utero images. Neuroimage, 185, pp.593-608.&lt;br /&gt;&lt;br /&gt;

Khan, S., Rollins, C.K., Ortinau, C.M., Afacan, O., Warfield, S.K. and Gholipour, A., 2018. Tract-specific group analysis in fetal cohorts using in utero diffusion tensor imaging. In Medical Image Computing and Computer Assisted Intervention–MICCAI 2018: 21st International Conference, Granada, Spain, September 16-20, 2018, Proceedings, Part III 11 (pp. 28-35). Springer International Publishing.&lt;br /&gt;&lt;br /&gt;
description: We have also released &lt;a href="https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/WE9JVR"&gt;a fetal T2 atlas&lt;/a&gt;, available on Harvard Dataverse
description: Please cite the following publications when referencing the IMAGINE 2019 fetal diffusion atlas.<br><br>

Khan, S., Vasung, L., Marami, B., Rollins, C.K., Afacan, O., Ortinau, C.M., Yang, E., Warfield, S.K. and Gholipour, A., 2019. Fetal brain growth portrayed by a spatiotemporal diffusion tensor MRI atlas computed from in utero images. Neuroimage, 185, pp.593-608.<br><br>

Khan, S., Rollins, C.K., Ortinau, C.M., Afacan, O., Warfield, S.K. and Gholipour, A., 2018. Tract-specific group analysis in fetal cohorts using in utero diffusion tensor imaging. In Medical Image Computing and Computer Assisted Intervention–MICCAI 2018: 21st International Conference, Granada, Spain, September 16-20, 2018, Proceedings, Part III 11 (pp. 28-35). Springer International Publishing.