cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5980303
title: Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction

description: Abstract Background: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. Objective: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. Methods: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10). Then, a swimming test with control of lactate production was performed. Based on its result, the lactate threshold (LT) was established to define the training intensities. After six weeks, the animals were reassessed by echocardiography and lactate production. Outcome measures were end-diastolic diameter (EDD), end-systolic diameter (ESD), left ventricular ejection fraction (LVEF, %) lactate at rest, lactate without overload, and lactate with 12g and 13.5g of additional load. Group comparisons of quantitative variables of the study were performed by one-factor analysis of variance (ANOVA). The Newman-Keuls test was used for multiple comparisons of the groups. Within-group comparisons of dependent variables between the two training protocols were performed by Student's t-test. Normality of the variables was tested by the Shapiro-Wilks test. Values of p &lt; 0.05 indicated statistical significance. Results: EDD, ESD, and LVEF before and after the training period were similar in within-group comparisons. However, EDD was significantly different (p=0.008) in the CG. Significant differences were found for L12g (p=0.002) and L13.5g (p = 0.032) in the ITG, and for L12g (p = 0.014) in the CG. No differences were found in the echocardiographic parameters between the groups. Significant differences were found in lactate without overload (p = 0.016) and L12 (p = 0.031) in the second assessment compared with the first, and between the groups - ITG vs. CG (p = 0.019) and CTG vs. CG (p = 0.035). Conclusion: Both methods produced a training effect without altering ventricular function.
DOI: 10.6084/m9.figshare.5980303.v1
title: Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction

description: Abstract Background: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. Objective: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. Methods: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10). Then, a swimming test with control of lactate production was performed. Based on its result, the lactate threshold (LT) was established to define the training intensities. After six weeks, the animals were reassessed by echocardiography and lactate production. Outcome measures were end-diastolic diameter (EDD), end-systolic diameter (ESD), left ventricular ejection fraction (LVEF, %) lactate at rest, lactate without overload, and lactate with 12g and 13.5g of additional load. Group comparisons of quantitative variables of the study were performed by one-factor analysis of variance (ANOVA). The Newman-Keuls test was used for multiple comparisons of the groups. Within-group comparisons of dependent variables between the two training protocols were performed by Student's t-test. Normality of the variables was tested by the Shapiro-Wilks test. Values of p &lt; 0.05 indicated statistical significance. Results: EDD, ESD, and LVEF before and after the training period were similar in within-group comparisons. However, EDD was significantly different (p=0.008) in the CG. Significant differences were found for L12g (p=0.002) and L13.5g (p = 0.032) in the ITG, and for L12g (p = 0.014) in the CG. No differences were found in the echocardiographic parameters between the groups. Significant differences were found in lactate without overload (p = 0.016) and L12 (p = 0.031) in the second assessment compared with the first, and between the groups - ITG vs. CG (p = 0.019) and CTG vs. CG (p = 0.035). Conclusion: Both methods produced a training effect without altering ventricular function.
DOI: 10.6084/m9.figshare.5980300
title: Preparation and Characterization of Mullite-Alumina Structures Formed "In Situ" from Calcined Alumina and Different Grades of Synthetic Amorphous Silica

description: The in situ reaction between alumina and silica to obtain mullite (Al6Si4O13) can be significantly affected by using synthetic amorphous silica (SAS) sources instead of crystalline ones (quartz and cristobalite). For instance, SASs promote early mullite formation (below 1300°C) and greater densification during sintering. This paper reports the "in situ" formation of mullite-alumina structures from fine calcined alumina (α-Al2O3) and four grades of SAS of different particles' morphology, specific surface area and internal porosity. After sintering assisted by dilatometry (up to 1500°C), the samples' total porosity, density and flexural strength were measured. The relative density and strength levels of some of these structures were greater than or comparable to other studies in which similar compositions were sintered at higher temperatures (1600-1700°C). Their microstructure assessment indicated that the specific surface area and internal porosity of SAS particles showed a major influence in the development of these physical properties.
DOI: 10.6084/m9.figshare.5980300.v1
title: Preparation and Characterization of Mullite-Alumina Structures Formed "In Situ" from Calcined Alumina and Different Grades of Synthetic Amorphous Silica

description: The in situ reaction between alumina and silica to obtain mullite (Al6Si4O13) can be significantly affected by using synthetic amorphous silica (SAS) sources instead of crystalline ones (quartz and cristobalite). For instance, SASs promote early mullite formation (below 1300°C) and greater densification during sintering. This paper reports the "in situ" formation of mullite-alumina structures from fine calcined alumina (α-Al2O3) and four grades of SAS of different particles' morphology, specific surface area and internal porosity. After sintering assisted by dilatometry (up to 1500°C), the samples' total porosity, density and flexural strength were measured. The relative density and strength levels of some of these structures were greater than or comparable to other studies in which similar compositions were sintered at higher temperatures (1600-1700°C). Their microstructure assessment indicated that the specific surface area and internal porosity of SAS particles showed a major influence in the development of these physical properties.
DOI: 10.6084/m9.figshare.5980297
title: Art – anthropology – art: the covers of the Horizontes Antropológicos magazine

description: Abstract From museum souvenirs to the focus of re-readings, the universe of art history has been used for different extra-artistic purposes. Constantly, filmmakers, designers and, in particular, professionals in the area of communication refer to it, taking fragments and allusions from this field to publicity campaigns, posters, visual identities, among others. This process can be frequently seen on the covers of Horizontes Antropológicos. Based on a reflection about the use of artistic images by the communication area and having as scope five specific issues of the magazine, this article investigates the artworks chosen, emphasizing some aspects such as representation and symbology, social function and trajectory. From a synthetic and thematic dialogue between art and anthropology, proposed by the editors of the magazine, an analytical dialogue emerges and justifies the historical value of this patrimony, taking into account its primordial value: the artistic one. From the artworks outline and approach, the construction by the artists of their own images can be emphasized, showing their role as social transformation agents.
DOI: 10.6084/m9.figshare.5980294
title: Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure

description: Abstract Background: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. Objective: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization in acute HF patients. Methods: Twenty-nine patients (systolic HF) were randomized into three groups: control (Control - only standard medical treatment); ET with placebo NIV (ET+Sham) and ET+NIV (NIV with 14 and 8 cmH2O of inspiratory and expiratory pressure, respectively). The 6MWT was performed on day 1 and day 10 of hospitalization and the ET was performed on an unloaded cycle ergometer until patients' tolerance limit (20 min or less) for eight consecutive days. For all analyses, statistical significance was set at 5% (p &lt; 0.05). Results: None of the patients in either exercise groups had adverse events or required exercise interruption. The 6MWT distance was greater in ET+NIV (Δ120 ± 72 m) than in ET+Sham (Δ73 ± 26 m) and Control (Δ45 ± 32 m; p &lt; 0.05). Total exercise time was greater (128 ± 10 vs. 92 ± 8 min; p &lt; 0.05) and dyspnea was lower (3 ± 1 vs. 4 ± 1; p &lt; 0.05) in ET+NIV than ET+Sham. The ET+NIV group had a shorter hospital stay (17 ± 10 days) than ET+Sham (23 ± 8 days) and Control (39 ± 15 days) groups (p &lt; 0.05). Total exercise time in ET+Sham and ET+NIV had significant correlation with length of hospital stay (r = -0.75; p = 0.01). Conclusion: Exercise training in acute HF was safe, had no adverse events and, when combined with NIV, improved 6MWT and reduce dyspnea and length of stay.
DOI: 10.6084/m9.figshare.5980297.v1
title: Art – anthropology – art: the covers of the Horizontes Antropológicos magazine

description: Abstract From museum souvenirs to the focus of re-readings, the universe of art history has been used for different extra-artistic purposes. Constantly, filmmakers, designers and, in particular, professionals in the area of communication refer to it, taking fragments and allusions from this field to publicity campaigns, posters, visual identities, among others. This process can be frequently seen on the covers of Horizontes Antropológicos. Based on a reflection about the use of artistic images by the communication area and having as scope five specific issues of the magazine, this article investigates the artworks chosen, emphasizing some aspects such as representation and symbology, social function and trajectory. From a synthetic and thematic dialogue between art and anthropology, proposed by the editors of the magazine, an analytical dialogue emerges and justifies the historical value of this patrimony, taking into account its primordial value: the artistic one. From the artworks outline and approach, the construction by the artists of their own images can be emphasized, showing their role as social transformation agents.
DOI: 10.6084/m9.figshare.5980294.v1
title: Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure

description: Abstract Background: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. Objective: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization in acute HF patients. Methods: Twenty-nine patients (systolic HF) were randomized into three groups: control (Control - only standard medical treatment); ET with placebo NIV (ET+Sham) and ET+NIV (NIV with 14 and 8 cmH2O of inspiratory and expiratory pressure, respectively). The 6MWT was performed on day 1 and day 10 of hospitalization and the ET was performed on an unloaded cycle ergometer until patients' tolerance limit (20 min or less) for eight consecutive days. For all analyses, statistical significance was set at 5% (p &lt; 0.05). Results: None of the patients in either exercise groups had adverse events or required exercise interruption. The 6MWT distance was greater in ET+NIV (Δ120 ± 72 m) than in ET+Sham (Δ73 ± 26 m) and Control (Δ45 ± 32 m; p &lt; 0.05). Total exercise time was greater (128 ± 10 vs. 92 ± 8 min; p &lt; 0.05) and dyspnea was lower (3 ± 1 vs. 4 ± 1; p &lt; 0.05) in ET+NIV than ET+Sham. The ET+NIV group had a shorter hospital stay (17 ± 10 days) than ET+Sham (23 ± 8 days) and Control (39 ± 15 days) groups (p &lt; 0.05). Total exercise time in ET+Sham and ET+NIV had significant correlation with length of hospital stay (r = -0.75; p = 0.01). Conclusion: Exercise training in acute HF was safe, had no adverse events and, when combined with NIV, improved 6MWT and reduce dyspnea and length of stay.
DOI: 10.6084/m9.figshare.5980285
title: Vimentin and Anti Vimentin Antibodies in Chagas' Disease

description: Abstract Background: Vimentin is a main structural protein of the cell, a component of intermediate cell filaments and immersed in cytoplasm. Vimentin is mimicked by some bacterial proteins and anti-vimentin antibodies occur in autoimmune cardiac disease, as rheumatic fever. In this work we studied vimentin distribution on LLC-MK2 cells infected with T. cruzi and anti-vimentin antibodies in sera from several clinical pictures of Chagas' disease or American Trypanosomiasis, in order to elucidate any vimentin involvement in the humoral response of this pathology. Objective: We standardized an indirect immunofluorescence assay (IFI) to determine sub cellular expression in either parasites and host cells, and ELISA to evaluate anti-vimentin antibodies in sera fron chagasic patients. Methods: We analyzed the distribution of vimentin in culture cells using indirect fluorescent assays, using as external controls anti-T. cruzi sera, derived from chronic infected patients for identification of the parasites in the same model. After infection and growth of T.cruzi amastigotes, those cells express larger amounts of vimentin, with heavy staining of cytoplasm outside the parasitophorous vacuole and some particle shadowing patterns, suggesting that vimentin are associated with cell cytoplasm. Anti-vimentin antibodies were present in most American trypanosomiasis samples, but notably, they are much more present in acute (76, 9%) or clinical defined syndromes, especially cardiac disease (87, 9%). Paradoxically, they were relatively infrequent in asymptomatic (25%) infected patients, which had a clearly positive serological reaction to parasite antigens, but had low frequency of anti-vimentin antibodies, similar to controls (2,5%). Conclusion: Our current data revealed that anti-vimentin antibodies induced during T. cruzi infection could be a marker of active disease in the host and its levels could also justify drug therapy in American Trypanosomiasis chronic infection, as a large group of asymptomatic patients would be submitted to treatment with frequent adverse reactions of the available drugs. Anti-vimentin antibodies could be a marker of cardiac muscle cell damage, appearing in American Trypanosomiasis patients during active muscle cell damage.
DOI: 10.6084/m9.figshare.5980285.v1
title: Vimentin and Anti Vimentin Antibodies in Chagas' Disease

description: Abstract Background: Vimentin is a main structural protein of the cell, a component of intermediate cell filaments and immersed in cytoplasm. Vimentin is mimicked by some bacterial proteins and anti-vimentin antibodies occur in autoimmune cardiac disease, as rheumatic fever. In this work we studied vimentin distribution on LLC-MK2 cells infected with T. cruzi and anti-vimentin antibodies in sera from several clinical pictures of Chagas' disease or American Trypanosomiasis, in order to elucidate any vimentin involvement in the humoral response of this pathology. Objective: We standardized an indirect immunofluorescence assay (IFI) to determine sub cellular expression in either parasites and host cells, and ELISA to evaluate anti-vimentin antibodies in sera fron chagasic patients. Methods: We analyzed the distribution of vimentin in culture cells using indirect fluorescent assays, using as external controls anti-T. cruzi sera, derived from chronic infected patients for identification of the parasites in the same model. After infection and growth of T.cruzi amastigotes, those cells express larger amounts of vimentin, with heavy staining of cytoplasm outside the parasitophorous vacuole and some particle shadowing patterns, suggesting that vimentin are associated with cell cytoplasm. Anti-vimentin antibodies were present in most American trypanosomiasis samples, but notably, they are much more present in acute (76, 9%) or clinical defined syndromes, especially cardiac disease (87, 9%). Paradoxically, they were relatively infrequent in asymptomatic (25%) infected patients, which had a clearly positive serological reaction to parasite antigens, but had low frequency of anti-vimentin antibodies, similar to controls (2,5%). Conclusion: Our current data revealed that anti-vimentin antibodies induced during T. cruzi infection could be a marker of active disease in the host and its levels could also justify drug therapy in American Trypanosomiasis chronic infection, as a large group of asymptomatic patients would be submitted to treatment with frequent adverse reactions of the available drugs. Anti-vimentin antibodies could be a marker of cardiac muscle cell damage, appearing in American Trypanosomiasis patients during active muscle cell damage.
DOI: 10.6084/m9.figshare.5980282
title: Figure 1&2

description: ddPCR dataset<br>
DOI: 10.6084/m9.figshare.5980282.v1
title: Figure 1&2

description: ddPCR dataset<br>
DOI: 10.6084/m9.figshare.5980234
title: The emergence and evanescence of Brazil’s new middle class

description: Abstract Between 2001 and 2013, Brazil’s economy grew with income redistribution. A result of inflationary stability, minimum wage increase, credit expansion and the widening of social policies, this period was characterized by the upward mobility of dozens of millions of Brazilians. Economists, journalists, politicians and marketers heralded the end of endemic poverty and the incorporation of this population into a newly defined “middle class”. Drawing from a documental ethnography, and from interviews with experts, this article pursuits the archeology of this category, problematizing the taxonomic ways of its emergence and evanescence. We argue that the “new middle class” must be understood as a scientific, political, and economic assemblage – one that is performed through statistic, governmental, and marketing alignments. Such diffuse scales of knowledge and power crystallized discursive fronts that rendered economic mobility legible in a country traditionally known for its stagnation and inequality.
DOI: 10.6084/m9.figshare.5980234.v1
title: The emergence and evanescence of Brazil’s new middle class

description: Abstract Between 2001 and 2013, Brazil’s economy grew with income redistribution. A result of inflationary stability, minimum wage increase, credit expansion and the widening of social policies, this period was characterized by the upward mobility of dozens of millions of Brazilians. Economists, journalists, politicians and marketers heralded the end of endemic poverty and the incorporation of this population into a newly defined “middle class”. Drawing from a documental ethnography, and from interviews with experts, this article pursuits the archeology of this category, problematizing the taxonomic ways of its emergence and evanescence. We argue that the “new middle class” must be understood as a scientific, political, and economic assemblage – one that is performed through statistic, governmental, and marketing alignments. Such diffuse scales of knowledge and power crystallized discursive fronts that rendered economic mobility legible in a country traditionally known for its stagnation and inequality.
DOI: 10.6084/m9.figshare.5980213
title: Largest case series of Latin American eyelid tumors over 13-Years from a single center in Sao Paulo, Brazil

description: ABSTRACT Purpose: Malignant lesions of the eyelid are the most common eye cancers. Although rarely lethal, late diagnosis can lead to serious visual morbidity. Definitive diagnosis of neoplastic lesions is pathological. Indications and types of eyelid lesions in a single high-volume ophthalmic reference center in Sao Paulo, Brazil, were analyzed. Methods: The surgical pathological reports of patients who underwent eye removal procedures between January 2000 and December 2012 were retrieved from the electronic database of the Ophthalmology Department and retrospectively reviewed. Data regarding the final anatomopathological diagnosis, sex, and age were analyzed via the χ2 test with Yates' correction. Results: Of the 1,113 eyelid tumors resected over the 13-year study period, 324 (29%) lesions were malignant. The most prevalent lesions were basal cell, squamous cell, and sebaceous gland carcinomas. The median ages of patients (females, n=165, 51%; males, n=159, 49%) with a diagnosis of basal cell, squamous cell, and sebaceous gland carcinomas were 65, 75, and 70 years, respectively. Conclusion: This is the largest retrospective cohort analysis of eyelid tumors in a Latin American population. These findings are in agreement with those from large centers in other countries and regions.
DOI: 10.6084/m9.figshare.5980213.v1
title: Largest case series of Latin American eyelid tumors over 13-Years from a single center in Sao Paulo, Brazil

description: ABSTRACT Purpose: Malignant lesions of the eyelid are the most common eye cancers. Although rarely lethal, late diagnosis can lead to serious visual morbidity. Definitive diagnosis of neoplastic lesions is pathological. Indications and types of eyelid lesions in a single high-volume ophthalmic reference center in Sao Paulo, Brazil, were analyzed. Methods: The surgical pathological reports of patients who underwent eye removal procedures between January 2000 and December 2012 were retrieved from the electronic database of the Ophthalmology Department and retrospectively reviewed. Data regarding the final anatomopathological diagnosis, sex, and age were analyzed via the χ2 test with Yates' correction. Results: Of the 1,113 eyelid tumors resected over the 13-year study period, 324 (29%) lesions were malignant. The most prevalent lesions were basal cell, squamous cell, and sebaceous gland carcinomas. The median ages of patients (females, n=165, 51%; males, n=159, 49%) with a diagnosis of basal cell, squamous cell, and sebaceous gland carcinomas were 65, 75, and 70 years, respectively. Conclusion: This is the largest retrospective cohort analysis of eyelid tumors in a Latin American population. These findings are in agreement with those from large centers in other countries and regions.