DOI: 10.20350/digitalcsic/17630
title: Dataset -Sodium lanthanide tungstate-based nanoparticles as bimodal probes for T1-T2 magnetic resonance imaging and X-ray computed tomography

description: Files List: Figure 1 F1b_Particle size histogram (b) of the synthesized nanoparticles Figure 2 F2a_blue XRD pattern of the synthesized nanoparticles F2a_red ticks corresponding to the tetragonal NaDy(WO4)2 (25-829 PDF file). F2b_FTIR spectrum of the tetragonal NaDy(WO4)2 nanoparticles F2c_TGA curve of the tetragonal NaDy(WO4)2 nanoparticles. Figure 3 F3_MES_black_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in MES, and aged undisturbed at 37ºC for 0 h. F3_MES_blue_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in MES, and aged undisturbed at 37ºC for 24 h. F3_MES_green_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in MES, and aged undisturbed at 37ºC for 48 h. F3_MES_red_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in MES, and aged undisturbed at 37ºC for 72 h. F3_Saline_black_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in saline, and aged undisturbed at 37ºC for 0 h. F3_Saline_blue_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in saline, and aged undisturbed at 37ºC for 24 h. F3_Saline_green_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in saline, and aged undisturbed at 37ºC for 48 h. F3_Saline_red_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in saline, and aged undisturbed at 37ºC for 72 h. F3_Water_black_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in water, and aged undisturbed at 37ºC for 0 h. F3_Water_blue_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in water, and aged undisturbed at 37ºC for 24 h. F3_Water_green_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in water, and aged undisturbed at 37ºC for 48 h. F3_Water_red_DLS curve obtained for the NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in water, and aged undisturbed at 37ºC for 72 h. Figure 5 F5c_Percentage of dead cells obtained from live-dead analysis F5d_black_Negative and positive control for live-dead analysis F5d_cyan_total number of cells per well obtained from live-dead analysis Figure 6 F6_black_negative and positive control for MTT assay F6_cyan_Mitochondrial activity of cells exposed to increasing concentration of the NaDy0.44Gd0.56(WO4)2@PAA nanoparticles evaluated by MTT assay Figure 7 F7c_EDX spectrum taken from the region marked with a white square in Figure 7 (a). Figure 8 F8_left_Viability of N2 worms incubated at 20°C with different NaDy0.44Gd0.56(WO4)2@PAA nanoparticles concentrations for 24h F8_right_Brood size (right) of N2 worms incubated at 20°C with different NaDy0.44Gd0.56(WO4)2@PAA nanoparticles concentrations for 24h Figure 9 F9a_blue_Relaxation rates 1/T1 measured at 3 T for aqueous dispersions of the NaDy0.44Gd0.56(WO4)2@PAA nanoparticles F9a_red_Relaxation rates 1/T1 measured at 1.44 T for aqueous dispersions of the NaDy0.44Gd0.56(WO4)2@PAA nanoparticles F9b_blue_Relaxation rates 1/T2 measured at 3 T for aqueous dispersions of the NaDy0.44Gd0.56(WO4)2@PAA nanoparticles F9b_red__Relaxation rates 1/T2 measured at 1.44 T for aqueous dispersions of the NaDy0.44Gd0.56(WO4)2@PAA nanoparticles Figure 11 F11_green_X-ray attenuation values (in Hounsfield units, HU) of NaDy0.44Gd0.56(WO4)2@PAA NPs dispersed in water F11_ red_X-ray attenuation values (in Hounsfield units, HU) of iohexol dispersed in water
description: Magnetic resonance imaging (MRI) is one of the most used imaging techniques for diagnosis in clinics. Often, magnetically-active substances, called contrast agents (CAs), have to be used, which increase contrast by shortening the longitudinal (T1) (resulting in signal enhancement in T1-weigthed images) and/or transverse (T2) (resulting in signal decay in T2-weighted images) relaxation times of the water protons present in biological tissues. A further strategy to improve diagnostic accuracy is recording both kinds of images (T1-weighted and T2-weighted) using dual T1-T2 CAs, which facilitates the exclusion of false positives. The traditional T1 or T2 contrast agents are not suitable for such a purpose. This paper deals with the development of double sodium lanthanide tungstate-based nanoparticles containing Gd3+ and Dy3+ cations, which are dispersible in physiological media, do not show appreciable in vitro (for human fibroblast cells) and in vivo (for C-elegans) toxicity and present appropriate relaxivity values for their use as a dual T1-T2 contrast agent for magnetic resonance imaging. In addition, they show an excellent X-ray attenuation capacity, thanks, mainly, to their tungsten content, which makes them also useful for X-ray computed tomography. Hence, the developed nanoparticles are ideal multimodal probes to be used as a dual T1-T2 contrast agent for magnetic resonance imaging and as a contrast agent for X-ray computed tomography.