cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30813182.v1
title: A systematic review of commencing full dose antihypertensives in newly diagnosed hypertension

description: This systematic review has explored the efficacy and safety of commencing full-dose antihypertensive treatment in individuals with essential hypertension. 16 randomised control trials (RCT’s) were eligible for inclusion, with some RCT’s assessing more than one treatment. The review assessed commonly used antihypertensive drugs (perindopril 8 mg, ramipril 10 mg, amlodipine 10 mg, losartan 100 mg, irbesartan 300 mg, candesartan 16 mg, and candesartan 32 mg) compared to low starting doses or placebo RCT’s. Eligible studies included 12 RCTs that compared full vs low doses and 19 RCTs that compared full starting doses vs placebo. The primary outcome was the difference in blood pressure reduction compared to controls (reported or calculated). Using full doses compared to low doses led to better BP reduction (overall, 3.9/2.2 mmHg lower achieved BP) without increase in adverse effects. This notion is supported by the changes achieved with full-dose treatment initiation compared to placebo (average over all studies: 11.4 [4.4]/6.5 [2.9] mmHg). The review indicates that initiating full dose antihypertensives for essential hypertension may be beneficial and safe. The available data are limited and further RCTs are required to assess this in specific patient groups to assess safety and efficacy. High blood pressure is the leading preventable cause of death and serious illness in the UK. When left untreated, it can lead to heart disease, stroke, kidney problems, and dementia. The good news is that high blood pressure is treatable. With proper medication and lifestyle changes, people can significantly reduce their risk of developing serious health problems. We conducted a comprehensive review of the existing research base to determine whether starting high blood pressure patients on full-strength medications from the beginning is more effective and safer than starting with lower doses. We found 16 high-quality studies involving commonly prescribed blood pressure medications, including perindopril, ramipril, amlodipine, losartan and irbesartan. The studies compared full doses versus low starting doses, and full doses versus inactive placebo pills. The results showed clear benefits to starting with full-strength medications. When patients began treatment with full doses rather than low doses, their blood pressure dropped. Importantly, starting with full doses did not cause more side effects than beginning with lower doses, suggesting this approach is safe for most patients with essential hypertension (high blood pressure without an underlying cause). These findings suggest that doctors could help patients achieve better blood pressure control more quickly by prescribing full-strength medications from the start, rather than gradually increasing doses over time. However, researchers note that more studies are needed to confirm this approach works safely across different patient populations.
DOI: 10.6084/m9.figshare.30032488
title: Weight loss following gastric bypass increases aldosterone reactivity to orthostatic stress in patients with obesity

description: Weight loss after gastric bypass is associated with blood pressure (BP) reduction. However, the precise role of the sympathetic nervous system (SNS) and renin-angiotensin-aldosterone system (RAAS) in this reduction remains unclear. We investigated the effect of RYGB-induced weight loss on the hemodynamic, hormonal and renal responses to an orthostatic stress induced by lower body negative pressure (LBNP). We conducted a monocentric study comparing response to LBNP (−30 mbar) in two groups of obese participants the first group underwent RYGB surgery (RYGB group) and the second group received lifestyle counselling (control group). We studied urinary sodium excretion, hemodynamic and hormonal responses before, during and 1 h after orthostatic stress induced by LBNP at three timelines: one month before planned RYGB (intervention group), and 3 and 12 months after the intervention. Thirty-seven adult participants were enrolled: 25 patients (72% women, age: 42.1 ± 10.5 years old, BMI 43.0 ± 5.1 kg/m<sup>2</sup>) in the RYGB group and 12 in control group (58% women, age: 44.8 ± 13.6 years old, BMI 43.3 ± 5.3 kg/m<sup>2</sup>). At 12 months, mean weight decreased from 126.3 ± 23.2 kg to 116 ± 20.7 kg in the control group and from 120.9 ± 19.4 kg to 78.6 ± 14.0 kg in the RYGB group (<i>p</i> value &lt; 0.01 between groups). During LBNP, the reduction in urinary sodium excretion (−1.98 mmol/h; CI95%: −3.72 to −0.30, <i>p</i> value = 0.02) and the increase in plasma aldosterone concentration (PAC; +9.94 pg/ml, CI 95%: 0.317–19.569, <i>p</i> value = 0.043) were more pronounced in the RYGB group. Our study suggests that weight loss induced by RYGB increases aldosterone responsiveness to orthostatic stress and enhances the sodium tubular response during orthostatic stress. NCT02218112
DOI: 10.6084/m9.figshare.30032488.v1
title: Weight loss following gastric bypass increases aldosterone reactivity to orthostatic stress in patients with obesity

description: Weight loss after gastric bypass is associated with blood pressure (BP) reduction. However, the precise role of the sympathetic nervous system (SNS) and renin-angiotensin-aldosterone system (RAAS) in this reduction remains unclear. We investigated the effect of RYGB-induced weight loss on the hemodynamic, hormonal and renal responses to an orthostatic stress induced by lower body negative pressure (LBNP). We conducted a monocentric study comparing response to LBNP (−30 mbar) in two groups of obese participants the first group underwent RYGB surgery (RYGB group) and the second group received lifestyle counselling (control group). We studied urinary sodium excretion, hemodynamic and hormonal responses before, during and 1 h after orthostatic stress induced by LBNP at three timelines: one month before planned RYGB (intervention group), and 3 and 12 months after the intervention. Thirty-seven adult participants were enrolled: 25 patients (72% women, age: 42.1 ± 10.5 years old, BMI 43.0 ± 5.1 kg/m<sup>2</sup>) in the RYGB group and 12 in control group (58% women, age: 44.8 ± 13.6 years old, BMI 43.3 ± 5.3 kg/m<sup>2</sup>). At 12 months, mean weight decreased from 126.3 ± 23.2 kg to 116 ± 20.7 kg in the control group and from 120.9 ± 19.4 kg to 78.6 ± 14.0 kg in the RYGB group (<i>p</i> value &lt; 0.01 between groups). During LBNP, the reduction in urinary sodium excretion (−1.98 mmol/h; CI95%: −3.72 to −0.30, <i>p</i> value = 0.02) and the increase in plasma aldosterone concentration (PAC; +9.94 pg/ml, CI 95%: 0.317–19.569, <i>p</i> value = 0.043) were more pronounced in the RYGB group. Our study suggests that weight loss induced by RYGB increases aldosterone responsiveness to orthostatic stress and enhances the sodium tubular response during orthostatic stress. NCT02218112
DOI: 10.6084/m9.figshare.29109006
title: Association between 24-hour blood pressure variability and mortality in acute ischemic stroke patients admitted in intensive care units: a MIMIC-IV study

description: Acute ischaemic stroke (AIS) patients in the intensive care unit (ICU) face high mortality. This study examined the association between systolic blood pressure variability (SBPV), specifically average real variability (SBP-ARV), and short-term mortality in critically ill AIS patients. We conducted a retrospective cohort study using the MIMIC-IV database. The primary outcomes were 28-day and 90-day all-cause mortality. Cox regression, Kaplan-Meier curves, restricted cubic spline (RCS) models, and subgroup analyses were used to assess associations. A total of 861 AIS patients were included. The 28-day and 90-day mortality rates were 20.9% and 23.3%, respectively. Higher SBP-ARV was independently associated with increased mortality. Compared with the lowest tertile, the highest tertile of SBP-ARV had significantly increased 28-day mortality (HR: 1.53; 95% CI: 1.03–2.27; <i>p</i> = 0.035). SBP-ARV as a continuous variable was also significantly associated with 28-day and 90-day mortality. RCS analysis showed that mortality risk increased when SBP-ARV exceeded 11.63. Our findings suggest that elevated systolic blood pressure variability, particularly higher SBP-ARV within the first 24 h of ICU admission, is significantly associated with increased 28-day and 90-day mortality in AIS patients. SBP-ARV may serve as a valuable prognostic marker for risk stratification and early clinical intervention in critically ill stroke patients. Stroke is a leading cause of death and disability worldwide. Some patients with severe strokes need to be treated in the intensive care unit (ICU), where close monitoring and advanced medical support are provided. However, many of these patients still face a high risk of death within a short period. Doctors are looking for reliable signs that can help predict which patients are at greater risk so that they can receive timely and targeted care. This study looked at changes in blood pressure over time—known as blood pressure variability (BPV)—in patients who had a severe ischaemic stroke and were admitted to the ICU. Using data from a large hospital database, we found that patients with greater fluctuations in their systolic blood pressure (the top number in a blood pressure reading) during the first 24 h in the ICU were more likely to die within 28 and 90 days. We also identified a specific threshold: once the fluctuation level exceeded a certain point, the risk of death increased steadily. This finding is important because blood pressure is a vital sign that is already measured routinely. Recognising dangerous levels of blood pressure variability early could help doctors identify high-risk stroke patients sooner. By doing so, healthcare teams could adjust treatments—such as blood pressure management—more effectively and potentially improve survival outcomes.
DOI: 10.6084/m9.figshare.29109006.v2
title: Association between 24-hour blood pressure variability and mortality in acute ischemic stroke patients admitted in intensive care units: a MIMIC-IV study

description: Acute ischaemic stroke (AIS) patients in the intensive care unit (ICU) face high mortality. This study examined the association between systolic blood pressure variability (SBPV), specifically average real variability (SBP-ARV), and short-term mortality in critically ill AIS patients. We conducted a retrospective cohort study using the MIMIC-IV database. The primary outcomes were 28-day and 90-day all-cause mortality. Cox regression, Kaplan-Meier curves, restricted cubic spline (RCS) models, and subgroup analyses were used to assess associations. A total of 861 AIS patients were included. The 28-day and 90-day mortality rates were 20.9% and 23.3%, respectively. Higher SBP-ARV was independently associated with increased mortality. Compared with the lowest tertile, the highest tertile of SBP-ARV had significantly increased 28-day mortality (HR: 1.53; 95% CI: 1.03–2.27; <i>p</i> = 0.035). SBP-ARV as a continuous variable was also significantly associated with 28-day and 90-day mortality. RCS analysis showed that mortality risk increased when SBP-ARV exceeded 11.63. Our findings suggest that elevated systolic blood pressure variability, particularly higher SBP-ARV within the first 24 h of ICU admission, is significantly associated with increased 28-day and 90-day mortality in AIS patients. SBP-ARV may serve as a valuable prognostic marker for risk stratification and early clinical intervention in critically ill stroke patients. Stroke is a leading cause of death and disability worldwide. Some patients with severe strokes need to be treated in the intensive care unit (ICU), where close monitoring and advanced medical support are provided. However, many of these patients still face a high risk of death within a short period. Doctors are looking for reliable signs that can help predict which patients are at greater risk so that they can receive timely and targeted care. This study looked at changes in blood pressure over time—known as blood pressure variability (BPV)—in patients who had a severe ischaemic stroke and were admitted to the ICU. Using data from a large hospital database, we found that patients with greater fluctuations in their systolic blood pressure (the top number in a blood pressure reading) during the first 24 h in the ICU were more likely to die within 28 and 90 days. We also identified a specific threshold: once the fluctuation level exceeded a certain point, the risk of death increased steadily. This finding is important because blood pressure is a vital sign that is already measured routinely. Recognising dangerous levels of blood pressure variability early could help doctors identify high-risk stroke patients sooner. By doing so, healthcare teams could adjust treatments—such as blood pressure management—more effectively and potentially improve survival outcomes.
DOI: 10.6084/m9.figshare.29109006.v1
title: Association Between 24-Hour Blood Pressure Variability and Mortality in Acute Ischemic Stroke Patients admitted in Intensive Care Units: A MIMIC-IV Study

description: Acute ischemic stroke (AIS) patients in the intensive care unit (ICU) face high mortality. This study examined the association between systolic blood pressure variability (SBPV), specifically average real variability (SBP-ARV), and short-term mortality in critically ill AIS patients. We conducted a retrospective cohort study using the MIMIC-IV database. The primary outcomes were 28-day and 90-day all-cause mortality. Cox regression, Kaplan-Meier curves, restricted cubic spline (RCS) models, and subgroup analyses were used to assess associations. A total of 861 AIS patients were included. The 28-day and 90-day mortality rates were 20.9% and 23.3%, respectively. Higher SBP-ARV was independently associated with increased mortality. Compared with the lowest tertile, the highest tertile of SBP-ARV had significantly increased 28-day mortality (HR: 1.53; 95% CI: 1.03–2.27; P = 0.035). SBP-ARV as a continuous variable was also significantly associated with 28-day and 90-day mortality. RCS analysis showed that mortality risk increased when SBP-ARV exceeded 11.63. Our findings suggest that elevated systolic blood pressure variability, particularly higher SBP-ARV within the first 24 hours of ICU admission, is significantly associated with increased 28-day and 90-day mortality in AIS patients. SBP-ARV may serve as a valuable prognostic marker for risk stratification and early clinical intervention in critically ill stroke patients. Stroke is a leading cause of death and disability worldwide. Some patients with severe strokes need to be treated in the intensive care unit (ICU), where close monitoring and advanced medical support are provided. However, many of these patients still face a high risk of death within a short period. Doctors are looking for reliable signs that can help predict which patients are at greater risk so that they can receive timely and targeted care. This study looked at changes in blood pressure over time—known as blood pressure variability (BPV)—in patients who had a severe ischemic stroke and were admitted to the ICU. Using data from a large hospital database, we found that patients with greater fluctuations in their systolic blood pressure (the top number in a blood pressure reading) during the first 24 hours in the ICU were more likely to die within 28 and 90 days. We also identified a specific threshold: once the fluctuation level exceeded a certain point, the risk of death increased steadily. This finding is important because blood pressure is a vital sign that is already measured routinely. Recognizing dangerous levels of blood pressure variability early could help doctors identify high-risk stroke patients sooner. By doing so, healthcare teams could adjust treatments—such as blood pressure management—more effectively and potentially improve survival outcomes.
DOI: 10.15468/dl.n2qbbn
title: Occurrence Download

description: A dataset containing 945 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is NZ National Vegetation Survey occurrence data",
 "TaxonKey is Pseudotsuga menziesii"
 ]
}

 The dataset includes 945 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050073-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kfbkmu
title: Occurrence Download

description: A dataset containing 43234 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is one of (Ammospiza nelsoni)",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence)",
 "Year is greater than or equal to 1951",
 "Year is less than or equal to 2024",
 "Month is greater than or equal to April",
 "Month is less than or equal to July",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 43234 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050075-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7k6tnt
title: Occurrence Download

description: A dataset containing 118 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Trollius macropetalus"
 ]
}

 The dataset includes 118 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050076-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bbyu94
title: Occurrence Download

description: A dataset containing 18492 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Japan, Korea (Democratic People’s Republic of), Korea, Republic of, Mongolia, Russian Federation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Caltha palustris"
 ]
}

 The dataset includes 18492 records from 182 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050077-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21227/cr1x-ra35
title: "Supplementary materials: Analytical Modeling and Full-Wave Simulation of Trihedral Corner Reflector Arrays"

description: "Supplementary materials: Analytical Modeling and Full-Wave Simulation of Trihedral Corner Reflector Arrays"
DOI: 10.15468/dl.6neh48
title: Occurrence Download

description: A dataset containing 32292 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is one of (Cypseloides niger)",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence)",
 "Year is greater than or equal to 1951",
 "Year is less than or equal to 2024",
 "Month is greater than or equal to April",
 "Month is less than or equal to July",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 32292 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050078-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b9fbad
title: Occurrence Download

description: A dataset containing 852 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Russian Federation, Mongolia, Korea, Republic of)",
 "TaxonKey is Knorringia sibirica"
 ]
}

 The dataset includes 852 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050079-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15472/h2f18v
title: Parcelas permanentes de vegetación de bosque de referencia como línea base a la restauración y aula viva - FPV Corredor de Vida del Cesar. Año 2025

description: I2D-BIO_2025_005. En el marco del convenio 141 del 2024, entre el Instituto de Investigación de Recursos Biológicos Alexander von Humboldt y el Fondo para la Vida y la biodiversidad, que tiene por objeto “Aunar esfuerzos técnicos, administrativos, jurídicos, financieros y operativos para la ejecución del proyecto “pactos hacia la restauración socioecológica y la bioeconomía sostenible en el corredor de vida del cesar”, para contribuir a las metas establecidas en el “programa corredor de vida del cesar” por fases, de acuerdo con la misionalidad del Instituto Humboldt”. Se realizó el presente conjunto de datos con la información taxonómica y estructural de 3 parcelas permanentes de vegetación de 0,12 ha correspondientes al componente 2. "Restauración y bioeconomía", del proyecto en el marco de la actividad de parcelas de línea base a la restauración y aula viva en el corredor de vida del Cesar. Se tomaron datos estructurales dasométricos tales como DAP, altura y posición espacial para todos los individuos vegetales con diámetro superior a 2,5 cm a una altura de 1,3 m. En total se reportaron 444 individuos arbóreos adultos para un total de 571 medidas asociadas a las ramas de los individuos arbóreos. De la misma manera se realizaron parcelas de regeneración natural de 1 x 1m en donde se registran dos registros adicionales.
DOI: 10.15468/dl.d747zt
title: Occurrence Download

description: A dataset containing 2682 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Russian Federation, Korea, Republic of, China, Japan)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Koenigia alpina"
 ]
}

 The dataset includes 2682 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050080-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yszqja
title: Occurrence Download

description: A dataset containing 5062 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Russian Federation, China, Mongolia, Japan, Korea (Democratic People’s Republic of), Korea, Republic of)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Bistorta vivipara"
 ]
}

 The dataset includes 5062 records from 112 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050082-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2lpdsh
title: CCDC 2403857: Experimental Crystal Structure Determination

description: Related Article: Sara Camorali, Lorenzo Tei, Marco Milanesio, Mattia Lopresti|2025|ChemistryOpen|14|e202500197|doi:10.1002/open.202500197
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2lpd8z
title: CCDC 2403841: Experimental Crystal Structure Determination

description: Related Article: Sara Camorali, Lorenzo Tei, Marco Milanesio, Mattia Lopresti|2025|ChemistryOpen|14|e202500197|doi:10.1002/open.202500197
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.