cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48370/ofd/nug9gh
title: Neomys anomalus - 75985, Zoological collection of the Mammal Research Institute, PAS

description: Neomys anomalus (Mediterranean water shrew) from Zoological collection of the Mammal Research Institute PAS. Collected 1968-07-12, in: Białowieża National Park, Poland. Material type: body
DOI: 10.48370/ofd/yimofn/xexvfq
title: MRIPAS_coll_75168_NeomysAnomalus_1968_scan.jpg

description: :unav
DOI: 10.48370/ofd/yimofn/kax5km
title: MRIPAS_coll_75168_NeomysAnomalus_1968_F_body_scan_ct.swf

description: :unav
DOI: 10.48370/ofd/yimofn
title: Neomys anomalus - 75168, Zoological collection of the Mammal Research Institute, PAS

description: Neomys anomalus (Mediterranean water shrew) from Zoological collection of the Mammal Research Institute PAS. Collected 1968-06-22, in: Białowieża National Park, Poland. Material type: body
DOI: 10.48370/ofd/h0fhol/i1wfqf
title: HMW_Allium_ursinum_L._H_2645.jpg

description: :unav
DOI: 10.48370/ofd/h0fhol
title: Czosnek niedźwiedzi (Allium ursinum L.), 2645

description: Herbarium
DOI: 10.6084/m9.figshare.19425209.v1
title: data file for Sustainability of the regional financial system: a case study of the Northwestern Federal District.xlsx

description: This is a data calculation for sustainability of regional financial system and is case study of the Northwestern Federal District in Russia <br>This article covers the study of assessing the sustainability of Russian regions’ financial systems. The study is based on the methods of generalization and synthesis, correlation-regression analysis, and multivariate classification methods. Since the regional financial system is a complex formation, many scientific works are devoted to studying sustainability issues of the financial system. Nevertheless, the relevance of the study topic is confirmed by the lack of a systematic approach to assessing the integral index of sustainability and the possibility of using various tools in determining the complex indicator. The use of the author’s methodology with the application of the methods of mathematical statistics makes it possible to assess the financial system sustainability in four sectors, to include in the assessment the indicators having the nature of leading indicators, and also to identify regions with extreme values of debt burden indicators. <br>Testing of the methodology using open data for the regions of the Northwestern Federal District for the period from 2010 to 2019 made it possible to obtain the following results: to classify the regions of the district according to three levels of debt sustainability; to identify the indicators of debt, financial, corporative and personal sustainability; to substantiate the key sustainability indicators for each of the selected sectors; to raise the problem of the low level of the financial system debt sustainability in 35% of the regions of the Northwestern Federal District (NWFD). During the study, the criteria values of the debt sustainability indicators were statistically substantiated, regulated by the Russian Federation's budget code. An increased level of financial system sustainability among the regions of the Northwestern Federal District is observed in the corporative and personal finance sectors, which indicates a significant contribution of businesses and households to maintaining the balance and sustainability of the financial system in Russia as a whole. Also, the study results allowed to identify regions with a constantly high level of debt, financial, corporative, and personal sustainability: the city of Saint Petersburg, the Leningrad, and the Kaliningrad regions.<br><br>
DOI: 10.48370/ofd/ztfqlv/gmmila
title: HMW_Allium_ursinum_L._H_0416.jpg

description: :unav
DOI: 10.48370/ofd/ztfqlv
title: Czosnek niedźwiedzi (Allium ursinum L.), 416

description: Herbarium
DOI: 10.48370/ofd/6vbvkn/hwmge8
title: MRIPAS_coll_75113_NeomysAnomalus_1968_scan.jpg

description: :unav
DOI: 10.48370/ofd/6vbvkn/5qb07d
title: MRIPAS_coll_75113_NeomysAnomalus_1968_F_body_scan_ct.swf

description: :unav
DOI: 10.48370/ofd/6vbvkn
title: Neomys anomalus - 75113, Zoological collection of the Mammal Research Institute, PAS

description: Neomys anomalus (Mediterranean water shrew) from Zoological collection of the Mammal Research Institute PAS. Collected 1968-06-22, in: Field in Białowieża, Poland. Material type: body
DOI: 10.48370/ofd/ukwpzn/n5lncr
title: MRIPAS_coll_75056_NeomysAnomalus_1968_scan.jpg

description: :unav
DOI: 10.48370/ofd/ukwpzn/nz2twv
title: MRIPAS_coll_75056_NeomysAnomalus_1968_M_body_scan_ct.swf

description: :unav
DOI: 10.48370/ofd/ukwpzn
title: Neomys anomalus - 75056, Zoological collection of the Mammal Research Institute, PAS

description: Neomys anomalus (Mediterranean water shrew) from Zoological collection of the Mammal Research Institute PAS. Collected 1968-06-21, in: Białowieża National Park, Poland. Material type: body
DOI: 10.48370/ofd/dtgmvx/bklthf
title: MRIPAS_coll_74935_NeomysAnomalus_1968_scan.jpg

description: :unav
DOI: 10.48370/ofd/dtgmvx/qgwewe
title: MRIPAS_coll_74935_NeomysAnomalus_1968_M_body_scan_ct.swf

description: :unav
DOI: 10.48370/ofd/dtgmvx
title: Neomys anomalus - 74935, Zoological collection of the Mammal Research Institute, PAS

description: Neomys anomalus (Mediterranean water shrew) from Zoological collection of the Mammal Research Institute PAS. Collected 1968-06-20, in: Białowieża National Park, Poland. Material type: body
DOI: 10.48370/ofd/yeshpz/eqniga
title: HMW_Anemone_narcissifolia_L._H_01314.jpg

description: :unav
DOI: 10.48370/ofd/yeshpz
title: Zawilec narcyzowy (Anemone narcissifolia L.), 1314

description: Herbarium
DOI: 10.5281/zenodo.6400353
title: The effect of intravitreal triamcinolone injection at the end of phacoemulsification surgery on central macular thickness and diabetic retinopathy progression

description: <strong>Purpose: </strong>To compare the efficacy of intraoperative intravitreal injection of triamcinolone acetonide with standard phacoemulsification on the central subfield macular thickness CSMT, distance corrected visual acuity CDVA, and the progression of diabetic retinopathy in diabetic patients. <strong>Setting: </strong>Al Mouassat university hospital, Damascus University, Damascus, Syria. <strong>Methods</strong>: In this prospective single-blinded randomized clinical trial, 50 patients with type 2 diabetes were randomly assigned to one group. The case received an intravitreal injection of triamcinolone acetonide IVTA at the end of phacoemulsification surgery, and the control had routine phacoemulsification surgery without any injection. Central subfield macular thickness CSMT, the progression of diabetic retinopathy DR, corrected distant visual acuity CDVA, intraocular pressure IOP, and adverse events like endophthalmitis, were compared between the 2 groups 1, 3, and 6 months postoperatively. CDVA and IOP were compared at one-week post-op as well.
DOI: 10.5281/zenodo.6400352
title: The effect of intravitreal triamcinolone injection at the end of phacoemulsification surgery on central macular thickness and diabetic retinopathy progression

description: <strong>Purpose: </strong>To compare the efficacy of intraoperative intravitreal injection of triamcinolone acetonide with standard phacoemulsification on the central subfield macular thickness CSMT, distance corrected visual acuity CDVA, and the progression of diabetic retinopathy in diabetic patients. <strong>Setting: </strong>Al Mouassat university hospital, Damascus University, Damascus, Syria. <strong>Methods</strong>: In this prospective single-blinded randomized clinical trial, 50 patients with type 2 diabetes were randomly assigned to one group. The case received an intravitreal injection of triamcinolone acetonide IVTA at the end of phacoemulsification surgery, and the control had routine phacoemulsification surgery without any injection. Central subfield macular thickness CSMT, the progression of diabetic retinopathy DR, corrected distant visual acuity CDVA, intraocular pressure IOP, and adverse events like endophthalmitis, were compared between the 2 groups 1, 3, and 6 months postoperatively. CDVA and IOP were compared at one-week post-op as well.
DOI: 10.6084/m9.figshare.16879453.v2
title: Prognostic assessment of the zone of occurrence of radiation combined injuries within a nuclear blast area

description: A detonation of nuclear weapon (NW) is considered as one of the most devastating radiological scenarios in the list of modern global threats. An essential proportion of victims in a mass casualty radiation event may require an immediate medical care due to radiation combined injuries (RCI). Surprisingly, there is a lack of clear guidance for quantitative prognosis of the spatial distribution of expected RCI casesin a given nuclear explosion scenario. This work is aimed at the presentation of a new, improved model, allowing more confident evaluation of the contributions from different NW destructive forces to RCI formation, thus leading to more accurate approximation of the zone around the epicenter for a guided search for RCI cases. The model is made compatible with a classic approach and provides the estimates of radial distance from the epicenter, at which NW explosion can produce RCI. Mathematical formalism comprises a set of equations for the reciprocal assessment of a distance–effect for radiation dose (separately for neutrons and gamma-rays), thermal wave and blast shock wave depending on the NW type, detonation yield and altitude, environmental conditions (i.e. season) and shielding factors. The model’s capabilities were demonstrated using an example of the RCI grade causing a profound operational performance decrement of military personnel in two marginal scenarios: Troops deployed in an open area or a tank crew. A remarkable difference in the expected radial zones of possible RCI occurrence was found between the actions of a ‘historical’ atomic bomb, thermonuclear weapons, and low-yield neutron munitions, also with a noticeable impact of the season factor (summer/winter). For a tank crew the clinically manageable RCI are possible only in very high yield explosion scenarios, while the damage caused by radiation alone possess much higher risk. Suggested formalism may provide guidance for a preliminary planning of countermeasures, targeting of radiation reconnaissance, and clarification of triage results in a broad range of radiological scenarios based on NW detonation. Further improvement of the model is possible by considering neutrons’ and gamma-rays’ relative biological efficacy, possible shielding factors, and a synergetic effect of NW’s destructive forces.
DOI: 10.6084/m9.figshare.17155724
title: mRNA and small RNA gene expression changes in peripheral blood to detect internal Ra-223 exposure

description: Excretion analysis is the established method for detection of incorporated alpha-emitting radionuclides, but it is laborious and time consuming. We sought a simplified method in which changes in gene expression might be measured in human peripheral blood to detect incorporated radionuclides. Such an approach could be used to quickly determine internal exposure in instances of a radiological dispersal device or a radiation accident. We evaluated whole blood samples from five patients with castration-resistant prostate cancer and multiple bone metastases (without visceral or nodal involvement), who underwent treatment with the alpha emitting isotope Radium-223 dichloride (Ra-223, Xofigo<sup>®</sup>). Patients received about 4 MBq per cycle and, depending on survival and treatment tolerance, were followed for six months. We collected 24 blood samples approximately monthly corresponding to treatment cycle. Firstly, we conducted whole genome screening of mRNAs (mRNA seq) and small RNAs (small RNA seq) using next generation sequencing in one patient at eight different time points during all six cycles of Ra-223-therapy. We identified 1900 mRNAs and 972 small RNAs (222 miRNAs) that were differentially up- or down-regulated during follow-up after the first treatment with Ra-223. Overall candidate RNA species inclusion criteria were a general (≥|2|-fold) change or with peaking profiles (≥|5|-fold) at specific points in time. Next we chose 72 candidate mRNAs and 101 small RNAs (comprising 29 miRNAs) for methodologic (<i>n</i> = 8 samples, one patient) and independent (<i>n</i> = 16 samples, four patients) validation by qRT-PCR. In total, 15 mRNAs (but no small RNAs) were validated by methodologic and independent testing. However, the deregulation occurred at different time points, showing a large inter-individual variability in response among patients. This proof of concept provides support for the applicability of gene expression measurements to detect internalized alpha-emitting radionuclides, but further work is needed with a larger sample size. While our approach has merit for internal deposition monitoring, it was complicated by the severe clinical condition of the patients we studied.
DOI: 10.6084/m9.figshare.17155724.v1
title: mRNA and small RNA gene expression changes in peripheral blood to detect internal Ra-223 exposure

description: Excretion analysis is the established method for detection of incorporated alpha-emitting radionuclides, but it is laborious and time consuming. We sought a simplified method in which changes in gene expression might be measured in human peripheral blood to detect incorporated radionuclides. Such an approach could be used to quickly determine internal exposure in instances of a radiological dispersal device or a radiation accident. We evaluated whole blood samples from five patients with castration-resistant prostate cancer and multiple bone metastases (without visceral or nodal involvement), who underwent treatment with the alpha emitting isotope Radium-223 dichloride (Ra-223, Xofigo<sup>®</sup>). Patients received about 4 MBq per cycle and, depending on survival and treatment tolerance, were followed for six months. We collected 24 blood samples approximately monthly corresponding to treatment cycle. Firstly, we conducted whole genome screening of mRNAs (mRNA seq) and small RNAs (small RNA seq) using next generation sequencing in one patient at eight different time points during all six cycles of Ra-223-therapy. We identified 1900 mRNAs and 972 small RNAs (222 miRNAs) that were differentially up- or down-regulated during follow-up after the first treatment with Ra-223. Overall candidate RNA species inclusion criteria were a general (≥|2|-fold) change or with peaking profiles (≥|5|-fold) at specific points in time. Next we chose 72 candidate mRNAs and 101 small RNAs (comprising 29 miRNAs) for methodologic (<i>n</i> = 8 samples, one patient) and independent (<i>n</i> = 16 samples, four patients) validation by qRT-PCR. In total, 15 mRNAs (but no small RNAs) were validated by methodologic and independent testing. However, the deregulation occurred at different time points, showing a large inter-individual variability in response among patients. This proof of concept provides support for the applicability of gene expression measurements to detect internalized alpha-emitting radionuclides, but further work is needed with a larger sample size. While our approach has merit for internal deposition monitoring, it was complicated by the severe clinical condition of the patients we studied.
DOI: 10.6084/m9.figshare.16879450.v1
title: Improved radiation expression profiling in blood by sequential application of sensitive and specific gene signatures

description: Combinations of expressed genes can discriminate radiation-exposed from normal control blood samples by machine learning (ML) based signatures (with 8–20% misclassification rates). These signatures can quantify therapeutically relevant as well as accidental radiation exposures. The prodromal symptoms of acute radiation syndrome (ARS) overlap those present in influenza and dengue fever infections. Surprisingly, these human radiation signatures misclassified gene expression profiles of virally infected samples as false positive exposures. The present study investigates these and other confounders, and then mitigates their impact on signature accuracy. This study investigated recall by previous and novel radiation signatures independently derived from multiple Gene Expression Omnibus datasets on common and rare non-neoplastic blood disorders and blood-borne infections (thromboembolism, <i>S. aureus</i> bacteremia, malaria, sickle cell disease, polycythemia vera, and aplastic anemia). Normalized expression levels of signature genes are used as input to ML-based classifiers to predict radiation exposure in other hematological conditions. Except for aplastic anemia, these blood-borne disorders modify the normal baseline expression values of genes present in radiation signatures, leading to false-positive misclassification of radiation exposures in 8–54% of individuals. Shared changes, predominantly in DNA damage response and apoptosis-related gene transcripts in radiation and confounding hematological conditions, compromise the utility of these signatures for radiation assessment. These confounding conditions (sickle cell disease, thrombosis, <i>S. aureus</i> bacteremia, malaria) induce neutrophil extracellular traps, initiated by chromatin decondensation, DNA damage response and fragmentation followed by programmed cell death or extrusion of DNA fragments. Riboviral infections (e.g. influenza or dengue fever) have been proposed to bind and deplete host RNA binding proteins, inducing R-loops in chromatin. R-loops that collide with incoming replication forks can result in incompletely repaired DNA damage, inducing apoptosis and releasing mature virus. To mitigate the effects of confounders, we evaluated predicted radiation-positive samples with novel gene expression signatures derived from radiation-responsive transcripts encoding secreted blood plasma proteins whose expression levels are unperturbed by these conditions. This approach identifies and eliminates misclassified samples with underlying hematological or infectious conditions, leaving only samples with true radiation exposures. Diagnostic accuracy is significantly improved by selecting genes that maximize both sensitivity and specificity in the appropriate tissue using combinations of the best signatures for each of these classes of signatures.
DOI: 10.6084/m9.figshare.16879450
title: Improved radiation expression profiling in blood by sequential application of sensitive and specific gene signatures

description: Combinations of expressed genes can discriminate radiation-exposed from normal control blood samples by machine learning (ML) based signatures (with 8–20% misclassification rates). These signatures can quantify therapeutically relevant as well as accidental radiation exposures. The prodromal symptoms of acute radiation syndrome (ARS) overlap those present in influenza and dengue fever infections. Surprisingly, these human radiation signatures misclassified gene expression profiles of virally infected samples as false positive exposures. The present study investigates these and other confounders, and then mitigates their impact on signature accuracy. This study investigated recall by previous and novel radiation signatures independently derived from multiple Gene Expression Omnibus datasets on common and rare non-neoplastic blood disorders and blood-borne infections (thromboembolism, <i>S. aureus</i> bacteremia, malaria, sickle cell disease, polycythemia vera, and aplastic anemia). Normalized expression levels of signature genes are used as input to ML-based classifiers to predict radiation exposure in other hematological conditions. Except for aplastic anemia, these blood-borne disorders modify the normal baseline expression values of genes present in radiation signatures, leading to false-positive misclassification of radiation exposures in 8–54% of individuals. Shared changes, predominantly in DNA damage response and apoptosis-related gene transcripts in radiation and confounding hematological conditions, compromise the utility of these signatures for radiation assessment. These confounding conditions (sickle cell disease, thrombosis, <i>S. aureus</i> bacteremia, malaria) induce neutrophil extracellular traps, initiated by chromatin decondensation, DNA damage response and fragmentation followed by programmed cell death or extrusion of DNA fragments. Riboviral infections (e.g. influenza or dengue fever) have been proposed to bind and deplete host RNA binding proteins, inducing R-loops in chromatin. R-loops that collide with incoming replication forks can result in incompletely repaired DNA damage, inducing apoptosis and releasing mature virus. To mitigate the effects of confounders, we evaluated predicted radiation-positive samples with novel gene expression signatures derived from radiation-responsive transcripts encoding secreted blood plasma proteins whose expression levels are unperturbed by these conditions. This approach identifies and eliminates misclassified samples with underlying hematological or infectious conditions, leaving only samples with true radiation exposures. Diagnostic accuracy is significantly improved by selecting genes that maximize both sensitivity and specificity in the appropriate tissue using combinations of the best signatures for each of these classes of signatures.
DOI: 10.6084/m9.figshare.16879453
title: Prognostic assessment of the zone of occurrence of radiation combined injuries within a nuclear blast area

description: A detonation of nuclear weapon (NW) is considered as one of the most devastating radiological scenarios in the list of modern global threats. An essential proportion of victims in a mass casualty radiation event may require an immediate medical care due to radiation combined injuries (RCI). Surprisingly, there is a lack of clear guidance for quantitative prognosis of the spatial distribution of expected RCI casesin a given nuclear explosion scenario. This work is aimed at the presentation of a new, improved model, allowing more confident evaluation of the contributions from different NW destructive forces to RCI formation, thus leading to more accurate approximation of the zone around the epicenter for a guided search for RCI cases. The model is made compatible with a classic approach and provides the estimates of radial distance from the epicenter, at which NW explosion can produce RCI. Mathematical formalism comprises a set of equations for the reciprocal assessment of a distance–effect for radiation dose (separately for neutrons and gamma-rays), thermal wave and blast shock wave depending on the NW type, detonation yield and altitude, environmental conditions (i.e. season) and shielding factors. The model’s capabilities were demonstrated using an example of the RCI grade causing a profound operational performance decrement of military personnel in two marginal scenarios: Troops deployed in an open area or a tank crew. A remarkable difference in the expected radial zones of possible RCI occurrence was found between the actions of a ‘historical’ atomic bomb, thermonuclear weapons, and low-yield neutron munitions, also with a noticeable impact of the season factor (summer/winter). For a tank crew the clinically manageable RCI are possible only in very high yield explosion scenarios, while the damage caused by radiation alone possess much higher risk. Suggested formalism may provide guidance for a preliminary planning of countermeasures, targeting of radiation reconnaissance, and clarification of triage results in a broad range of radiological scenarios based on NW detonation. Further improvement of the model is possible by considering neutrons’ and gamma-rays’ relative biological efficacy, possible shielding factors, and a synergetic effect of NW’s destructive forces.
DOI: 10.48370/ofd/l3ddhj/asf0ko
title: HMW_Anemone_sylvestris_L._H_8120.jpg

description: :unav
DOI: 10.48370/ofd/l3ddhj
title: Zawilec wielkokwiatowy (Anemone sylvestris L.), 8120

description: Herbarium
DOI: 10.48370/ofd/xjdutw/tbstu4
title: HMW_Anemone_sylvestris_L._H_6810.jpg

description: :unav
DOI: 10.48370/ofd/xjdutw
title: Zawilec wielkokwiatowy (Anemone sylvestris L.), 6810

description: Herbarium