cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26182943
title: Supplementary Material for: Efficacy and Safety of Anti-Osteoporotic Agents Across CKD Stages: A Meta-Analysis of Randomized Clinical Trials

description: Introduction: Osteoporosis poses a significant health concern, especially for individuals with chronic kidney disease (CKD). CKD disrupts mineral and bone metabolism, heightening the risk of fractures and complicating the management of osteoporosis. While anti-osteoporotic interventions aim to address bone health in CKD patients, ongoing research is essential to understand the comparative efficacy and safety of these medications, particularly in different CKD stages, notably in Stages 4 and 5.

Methods: We searched PubMed/MEDLINE, EMBASE, and the Cochrane CENTRAL for randomized controlled trials assessing the efficacy and safety of osteoporosis interventions in CKD up to June 15, 2024. The analysis utilized the pooled odds ratio (OR) along with the corresponding 95% confidence interval (CI), employing Comprehensive Meta-Analysis software, version 3.0. To assess heterogeneity in the results of individual studies, we used Cochran's Q statistic and the I2 statistic.

Results: We analyzed 12 randomized controlled trials involving 31,027 participants, revealing a significantly lower risk of vertebral fractures with anti-osteoporotic agents (Teriparatide, Denosumab, Romosozumab, Raloxifene) compared to placebo (pooled OR, 0.28 [95% CI, 0.22 to 0.36]). Stratification by CKD stages showed a lower risk in Stages 1-3 but no significant reduction in Stages 4 and 5. 
Teriparatide, Denosumab, and Romosozumab were effective in lowering fracture risk, whereas Raloxifene showed no significant effect. 
The lumbar spine, femoral neck, and total hip BMD showed no significant differences between anti-osteoporotic agents (Denosumab, Raloxifene, Risedronate, Alendronate, Teriparatide) and placebo. However, Romosozumab demonstrated a significantly greater BMD change in all kidney function categories. No reported side effects were observed in CKD stages 1 to 5 across the trials.

Conclusions: Our meta-analysis highlights the effectiveness of anti-osteoporotic agents in lowering vertebral fracture risk in CKD patients, particularly in Stages 1-3. However, this benefit is not apparent in Stages 4 and 5, necessitating further research. Despite the absence of reported side effects in CKD patients, clinicians should carefully assess the suitability of these medications, considering individual risks and benefits.
DOI: 10.15156/bio/587480
title: Full mothur UNITE+INSD dataset 2

description: this dataset comprises of all quality filtered unclustered UNITE + INSD sequences in mothur format.
DOI: 10.17632/vsxsjhp6n3.1
title: FEMINA2

description: Hypothesis: Reduced fetal movements is a symptom of placental insufficiency. This insufficiency can be detected antenatally using placental ultrasound, fetomaternal Doppler ultrasound and quantification of fetoplacentally-derived factors in the maternal circulation. Detecting placental insufficiency antenatally can predict placentally-derived adverse pregnancy outcome Methods: a cohort study of 300 singleton, non-anomalous pregnancies where mothers reported at least one episode of reduced fetal movements after at least 28 weeks gestation. Details of the methods of the study can be found in the related publications (PMID 27238714, INSERT PMID'S HERE) . Results: 300 participants were recruited. 2 were lost to follow up. 2 received postnatal diagnoses of significant fetal abnormalities and were excluded. 61/296 (20.6%) experienced adverse pregnancy outcome. Combining measures of placental function (PlGF/sFlt1 ratio and umbilical artery Doppler impedance) with estimation of fetal weight demonstrated improved test performance characteristics. Details of the results can be found in the related publication (INSERT PMID HERE). Conclusion: This study identified two clinical measures relating to placental health that have the potential to incrementally improve prediction of adverse pregnancy outcome after reduced fetal movements. However, these tests require further development and evaluation of their link to placental dysfunction and fetal wellbeing. The full diagnostic potential of these tests, particularly of the PlGF/sFlt1 ratio, needs to be prospectively assessed in future studies.
DOI: 10.34740/kaggle/dsv/2066096
title: BdSlHD-2300
DOI: 10.5281/zenodo.10045687
title: Data for "Strong El Niño events lead to robust multi-year ENSO predictability"

description: The full raw data, intermediate steps, and final results for all three experiments used in Lenssen et al. (202X), "Strong El Niño events lead to robust multi-year ENSO predictability," as submitted to GRL. Each zip file contains the raw data, intermediate steps, and final results for model analog forecast issued to predict that model or observational record. All data has been gridded to a common 2x2 grid using nco following the include `mygrid_2x2` file.
Archived codebase for this data available at https://zenodo.org/doi/10.5281/zenodo.10045615Live codebase at https://github.com/nlenssen/LongLeadENSO/
DOI: 10.5281/zenodo.10212951
title: Open Research Datasets – Testing Mantle Convection Simulations with Paleobiology and Other Stratigraphic Observations: Examples from Western North America

description: Data supporting the findings of "Testing Mantle Convection Simulations with Paleobiology and Other Stratigraphic Observations: Examples from Western North America" by Victoria M. Fernandes, Gareth G. Roberts and Fred D. Richards. Further details about these data can be found in the main manuscript and accompanying Supporting Information. This research was funded by NERC Large Grant MC2: Mantle Convection Constrained (NE/T012595/1). The datasets contained in this repository:1) Uplift constraints from youngest outcropping marine to terrestrial stratigraphic transitions, as described in Fernandes et al. (2019) JGR Earth Surface (Figure 1; MarineTerrestrialTransition_Fernandes_etal2019.txt)2) Digitised sediment isopachs from Roberts & Kirschbaum (1995), USGS Professional Paper 1561 (Supplementary Figure S3; Roberts_Kirschbaum_1995_isopachs.zip)3) Air-loaded subsidence grids (Supplementary Figure S4; Subsidence.zip)4) Temperature grids at 25 km depth intervals, from 50–400 km depth, generated from the SLNAAFSA hybrid Vs model of Hoggard et al. (2020), Nature Geoscience (Supplementary Figure S6; Temperature_grids_txt.zip)
DOI: 10.5281/zenodo.12616640
title: Dataset for "Stability of H2O-rich fluid in the deep mantle indicated by the MgO-SiO2-H2O phase relations at 23 GPa and 2000 K" by H. Fei

description: This dataset provides the EPMA and XRD data for "Stability of H2O-rich fluid in the deep mantle indicated by the MgO-SiO2-H2O phase relations at 23 GPa and 2000 K" by H. Fei.
DOI: 10.5281/zenodo.6846130
title: S29 | PHYTOTOXINS | Toxic Plant Phytotoxin (TPPT) Database

description: This is the collection associated with list S29 PHYTOTOXINS on the NORMAN Suspect List Exchange. https://www.norman-network.com/nds/SLE/ S29 PHYTOTOXINS <strong>Toxic Plant Phytotoxin (TPPT) Database</strong> TPPT Original File (27/06/2018)<br> TPPT Phytotoxins CSV, XLSX (23/01/2019 - updated 20/11/2019 to correct InChIKey errors) TPPT InChIKeys (22/03/2019 - ) A comprehensive toxic plant-phytotoxin (TPPT) database provided by Günthardt et al 2018, DOI: 10.1021/acs.jafc.8b01639<br> More information on the Agroscope TPPT website. Updated 20/11/2019 to correct InChIKey errors; updated 16/7/2022 to create merged SMILES column for PubChem deposition.
description: For more author details please see original publication DOI: 10.1021/acs.jafc.8b01639
DOI: 10.6084/m9.figshare.24941358
title: Molasses concentration (15, 20, 25, 30 and 35 °Brix), and pH (3.5, 4.0, 4.5, 5.0, and 5.5) of data analysis

description: Parameters analysis in SPSS version 25 such as molasses concentration (15, 20, 25, 30, and 35 °Brix), and pH (3.5, 4.0, 4.5, 5.0, and 5.5) were optimized using fed-batch fermentation.
DOI: 10.6084/m9.figshare.25827115
title: Supplementary Material for: Factors considered by experienced urologists when selecting alpha-blockers for patients with lower urinary tract symptoms or benign prostatic hyperplasia according to age

description: Introduction: To examine the opinions of urology specialists on whether there are actual differences in efficacy among α1-blockers and to identify the factors that should be considered when prescribing these medications according to age.

Methods: We surveyed 50 South Korean urology specialists with over 3 years of clinical experience in secondary or tertiary hospitals in July-August 2021. The survey covered urologists' demographics, awareness of α1-blocker prescription differences, and key factors in α1-blocker selection based on LUTS severity and patient age.

Results: Overall, 82% of the respondents believed that there were differences in efficacy of α1-blockers in actual practice according to age. Over 90% of the respondents agreed on the need for head-to-head comparison studies to compare the effects of different α1-blockers. Regardless of the severity of LUTS, urologists prioritize cardiovascular side effects when prescribing α1-blockers to patients aged ≥70 years. Further, 19% of the urologists prioritized ejaculatory side effects for mild-to-moderate LUTS and 9% for severe LUTS (p &lt; 0.001). 

Conclusions: This study shows that head-to-head studies comparing the efficacy of different α1-blockers are highly valuable for the real-world clinical application of α1-blockers. Notably, urologists prioritize cardiovascular and ejaculatory side effects in older and younger patients while prescribing α1-blockers, respectively.
DOI: 10.6084/m9.figshare.25975141
title: Supplementary Material for: Genetic findings in short Turkish children born to consanguineous parents

description: Introduction
The diagnostic yield of genetic analysis in the evaluation of children with short stature depends on associated clinical characteristics, but the additional effect of parental consanguinity has not been well documented. 
Methods
This observational case series of 42 short children from 34 consanguineous families was collected by six referral centres of paediatric endocrinology (inclusion criteria: short stature and parental consanguinity). In eighteen patients (12 families, Group 1), the clinical features suggested a specific genetic defect in the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis, and a candidate gene approach was used. In others (Group 2) a hypothesis-free approach was chosen (gene panels, microarray analysis, and whole-exome sequencing), further subdivided into 11 patients with severe short stature (height &lt;-3.5 SDS) and microcephaly (head circumference &lt;-3.0 SDS) (group 2a), 10 patients with syndromic short stature (group 2b) and were 3 patients with nonspecific isolated GH deficiency (group 2c). 
Results
In all 12 families from group 1, (likely) pathogenic variants were identified in GHR, IGFALS, GH1, and STAT5B. In 9/12 families from group 2a, variants were detected in PCNT, SMARCAL1, SRCAP, WDR4 and GHSR. In 5/9 families from group 2b, variants were found in TTC37, SCUBE3, NSD2, RABGAP1, and 17p13.3 microdeletions. In group 2c no genetic cause was found. Homozygous, compound heterozygous and heterozygous variants were found in 21, 1 and 4 patients, respectively. 
Conclusion
Genetic testing in short children from consanguineous parents has a high diagnostic yield, especially in cases of severe GH deficiency or insensitivity, microcephaly, and syndromic short stature.
DOI: 10.6084/m9.figshare.25997245
title: Supplementary Material for: Differences in cognitive trajectories of dementia: Comparison Alzheimer’s disease dementia and Dementia with Lewy bodies in Korean patient cohort

description: Background and purpose: 
Prediction of the dementia progression is important for patient management. We aimed to investigate the cognitive trajectories of Alzheimer’s disease dementia (ADD) and dementia with Lewy bodies (DLB) according to the initial structural change measured by comprehensive visual rating scales (CVRS).
Methods
We retrospectively included the patients who initially visited the Dementia Clinic of Chonnam National University Hospital between 2010 to 2012. All patients underwent dementia work up including neuropsychological battery (Seoul Neuropsychological Screening Battery, SNSB). We recruited the participant who underwent SNSB annually for three years successively. Total 136 patients of ADD and 63 patients of DLB were included for analyze. We analyzed the decline pattern of cognitive profile according to the initial brain structural changes. 
Results
The general cognitive trajectories between ADD and DLB patients were not different. However, DLB patients showed more rapid decline of cognitive function in language and related function, visual memory function, and frontal executive function. The scores were lower in participants with DLB with lesser atrophy group in attention, visuospatial function, and frontal executive function. In analysis of the cognitive trajectories, the visual memory domain declined rapidly in DLB with lesser atrophy group compared with the ADD with lesser atrophy group.
Conclusion
We founded that the differences in visual cognitive profile in ADD and DLB patients in serial follow up of neuropsychological tests. It is prominent in the mild structural change group of ADD and DLB.
DOI: 10.6084/m9.figshare.26247914
title: Supplementary Material for: Periostin predicts all-cause mortality in male but not female end-stage renal disease patients on hemodialysis

description: Background: Periostin is a matricellular protein. Elevated serum concentrations of periostin have been reported in patients with various cardiovascular diseases, including heart failure. Patients with end-stage renal disease have a substantially increased risk for cardiovascular diseases. However, there is a lack of clinical studies to clarify the prognostic significance of systemic periostin on all-cause mortality in patients with end-stage renal disease on hemodialysis.

Methods: 313 stable end-stage renal disease patients were recruited and followed for five years concerning all-cause mortality. At baseline, we collected blood samples and clinical data. Serum periostin concentrations were measured using a certified ELISA.

Results: The optimal cut-off value for serum periostin regarding all-cause mortality, calculated through ROC analysis, was 777.5 pmol/l. Kaplan-Meier survival analysis using this cut-off value demonstrated that higher periostin concentrations are linked to higher all-cause mortality (log-rank test: P = 0.002). Subgroup analysis revealed that serum periostin concentrations only affected all-cause mortality in male but not in female patients (P = 0.002 in male patients and P = 0.474 in female patients). Multivariate Cox regression analyses, adjusted for confounding factors, likewise showed that elevated serum periostin concentrations were positively associated with all-cause mortality in male (P = 0.028) but not in female patients on hemodialysis (P = 0.313).

Conclusion: Baseline serum periostin is an independent risk factor for all-cause mortality in male patients with chronic renal disease on hemodialysis.
DOI: 10.6084/m9.figshare.26298868
title: Supplementary Material for: Quality of Life in Recurrent Respiratory Papillomatosis Patients After Vocal Fold Surgery: An In-Depth Exploration

description: Introduction: This study explores the quality of life among patients with Recurrent Respiratory Papillomatosis (RRP) after vocal fold surgery as measured by the outcome scores of the Voice Handicap Index (VHI) and the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis (DT&PL). Differences in quality of life were explored within the independent variables age, surgical frequency, weeks since last vocal fold operation, gender, HPV type, surgical location, vaccination with Gardasil©, and a patient’s request to speak with a speech-language pathologist.
 
Methods: A single-center, observational cohort study was conducted with VHI and DT&PL scores and demographic and clinical data obtained from patient files. Inclusion criteria were a confirmed HPV type, age 18 years or older, the ability to fill in both questionnaires in Dutch, and having undergone at least one surgical procedure to remove laryngeal papilloma. Relationships of the independent variables with VHI and Distress Thermometer (DT) scores were explored using univariable and multivariable regressions as well as linear regression models. 
 
Results: Of 271 RRP patients, 100 met the inclusion criteria and responded to requests to fill in both questionnaires with a minimum of 12 weeks after their last operation. Our study showed a statistically significant negative relationship between age and VHI scores (P=0.02) in the univariable, and multiple linear regressions (P=0.01), indicating that patients experienced fewer self-perceived functional voice disabilities with each increase in age. A parallel negative relationship is seen between the variables age (P=0.03) and DT scores. Our results showed a statistically significant positive relationship between the number of vocal fold surgeries and DT scores (P=0.03).
 
Conclusion: The results of this study show a significant relationship between age, surgical frequency, and quality of life in patients with Recurrent Respiratory Papillomatosis (RRP). Older patients have lower Voice Handicap Index (VHI) and Distress Thermometer (DT scores), indicating fewer self-perceived voice and disease-related quality of life problems. Conversely, a rise in surgical frequency is significantly associated with higher DT scores, reflecting greater disease-related distress.
DOI: 10.6084/m9.figshare.26303590
title: Supplementary Material for: The prognostic test accuracy of the short and standard forms of the Montreal Cognitive Assessment.

description: Introduction
Cognitive impairment is a critical concern in stroke care, and international guidelines recommend early cognitive screening. The aim of this study was to determine the prognostic accuracy of both the short and standard forms of the Montreal Cognitive Assessment in predicting long-term cognitive recovery following a stroke.

Methods
For this study, we used data from the "Efficacy of Fluoxetine – a Randomized Controlled Trial in Stroke" (EFFECTS) study, which encompassed stroke patients from 35 Swedish centers over the period from 2014 to 2019. Cognitive assessments were initially conducted at 2 to 15 days post-stroke, with follow-up data gathered at 6 months. We used the MoCA for objective cognitive evaluation. For assessing subjective cognitive impairment, we used the memory and thinking domain of the Stroke Impact Scale. For psychometric evaluation of the short Swedish version of MoCA (s-MoCA-SWE), we used cross tables and binary logistic regression.

Results
The study included 1141 patients (62.2% men; median [interquartile range, IQR] age, 72.3 [13.2] years; median [IQR] stroke severity, 3.0 [3.0]). At baseline, the prevalence of cognitive impairment was 71.7% according to the s-MoCA-SWE (≤12) and 67.0% according to the MoCA (≤25). The s-MoCA-SWE demonstrated a sensitivity of 92.3% for correctly identifying patients with objective cognitive impairment and 81.5% for identifying those with subjective impairments at 6 months. Although the s-MoCA-SWE had higher sensitivity, the MoCA had a more balanced sensitivity and specificity in detecting both subjective and objective cognitive impairments. In both crude and multivariable models, the s-MoCA-SWE was more strongly associated than the MoCA with cognitive impairment at 6 months.

Conclusions
Both the short and standard versions of the MoCA appear to be effective in identifying individuals likely to experience persistent cognitive issues following a stroke. Considering the limited time available in an acute stroke unit, the short-form version may be more practical. Nevertheless, further prospective studies are required to validate these findings.
DOI: 10.6084/m9.figshare.26334907
title: Supplementary Material for: Family history of stroke is associated with large- and small-vessel etiology: a systematic review and meta-analysis

description: Background:
Several studies have investigated the association between family history of stroke (FHS) and stroke etiology, recurrence or mortality, however the results have been discrepant. We conducted a systematic review with meta-analysis to further evaluate the associations.
Materials and Methods:
We searched Scopus database using the term “family history” AND “stroke” up to December 2023 to identify observational studies and systematic reviews reporting both the prevalence of FHS and the rates of stroke etiology or recurrence or mortality. Case reports, series and narrative reviews were excluded. We used odds ratio as a common measure of association and I2 to determine heterogeneity of effects across studies.
Results:
We have identified 22 articles (130 999 patients, 53% female), which met the pre-specified inclusion criteria. After pooling the results, FHS was associated with large-vessel (OR, 1.24, 95%CI [1.07-1.44]), as well as small-vessel (OR, 1.17, 95%CI [1.05-1.31]), but not cardioembolic stroke etiology (OR, 0.74, 95%CI [0.60-0.90]). There was no relationship between FHS and stroke recurrence (OR, 1.16, 96%CI [0.84-1.61]), nor mortality (0.94, 95%CI [0.63-1.41]).
Conclusions:
FHS is associated with large- and small-vessel stroke etiology, but not stroke recurrence or mortality. These findings might be useful to physicians caring for stroke patients in their everyday practice.
DOI: 10.6084/m9.figshare.26249105
title: Supplementary Material for: Comparative performance of five cognitive screening tests in a large sample of seniors

description: Introduction
Recent introductions of disease-modifying treatments for Alzheimer’s disease have re-invigorated
the cause of early dementia detection. Cognitive “Paper & pencil” tests represent the bedrock of
clinical assessment, because they are cheap, easy to perform, and don’t require brain imaging or
biological testing. Cognitive tests vary greatly in duration, complexity, sociolinguistic biases, probed
cognitive domains, and their specificity and sensitivity of detecting cognitive impairment (CI).
Consequently, an ecologically valid head-to-head comparison seems essential for evidence-based
dementia screening.
Method
We compared five tests: MoCA, ADAS, ACE-III, Eurotest, and Phototest on a large sample of seniors
(N=456, 77.9 ± 8 years, 71% females). Their specificity and sensitivity was estimated in a novel way
by contrasting each test’s outcome to the majority outcome across the remaining tests (Comparative
Specificity & Sensitivity Calculation – CSSC). This obviates the need for an a priori gold standard such
as a clinically clear-cut sample of dementia/MCI/controls. We posit that the CSSC results in a more
ecologically valid estimation of clinical performance while precluding biases resulting from different
dementia/MCI diagnostic criteria, and the proficiency of detecting these conditions.
Results
There exists a stark trade-off between behavioral test specificity and sensitivity. The test with the
highest specificity had the lowest sensitivity, and vice versa. The comparative specificities and
sensitivities were, respectively: Phototest (97%, 47%), Eurotest (94%, 55%), ADAS (90%, 68%), ACE-III
(72%, 77%), MoCA (55%, 95%).
Conclusion
Assuming a CI prevalence of 10%, the shortest (~3 min) and the simplest instrument - the Phototest,
was shown to have the best overall performance (accuracy 92%, PPV 66%, NPV 94%).