cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7466732.v1
title: Supplementary Material for: Autonomic Symptoms Correlate with Non-Autonomic Non-Motor Symptoms and Sleep Problems in Patients with Parkinson’s Disease

description: <b><i>Objective:</i></b> The objective of this study was to clarify the relationship between autonomic and non-autonomic non-motor symptoms in patients with Parkinson’s disease (PD). <b><i>Methods:</i></b> Sixty-five PD patients were included in this study (27 men and 38 women; aged 68.5 ± 10.0; Hoehn and Yahr (HY) stage 2.6 ± 1.1). The autonomic symptoms were evaluated by the Japanese version of the Scales for outcomes in PD autonomic (SCOPA-AUT) questionnaire. The patients were assessed with the mini-mental state examination (MMSE), PD sleep evaluation scale-2 (PDSS-2), Epworth sleepiness scale (ESS) and Beck’s depression inventory II (BDI-II). The Non-Motor Symptom Scale (NMSS) total scores and subscores of non-autonomic non-motor symptom domains (sleep/fatigue, mood/cognition, perceptual problems/hallucination, and attention/memory) were evaluated. A dopamine transporter (DAT) scan, metaiodobenzylguanidine (MIBG) myocardial scintigraphy, and card type olfactory identification test (open essence [OE, Wako]) were performed. <b><i>Results:</i></b> The SCOPA-AUT total score was positively correlated with the disease duration, HY stage, levodopa equivalent dose, PDSS-2, ESS, BDI-II and non-autonomic NMSS and inversely correlated with the MMSE. The high-SCOPA-AUT group (≥9) had lower MMSE scores and higher PDSS-2, ESS, BDI-II and non-motor NMSS scores than the low-SCOPA-AUT group (&lt; 9). The DAT scan, MIBG uptake and OE score did not differ between the groups. In a stepwise linear regression analysis, which excluded possibly overlapping items among the scales, the subtotals of PDSS-2 items, except for item 8 (nocturia), (<i>p</i> &lt; 0.0001) and non-autonomic NMSS domains (<i>p</i> = 0.00040) were significant predictors of the total SCOPA-AUT score. <b><i>Conclusion:</i></b> Our study shows significant correlations among autonomic symptoms, PD-related sleep problems and non-autonomic non-motor symptoms in PD patients.
DOI: 10.6084/m9.figshare.7466708
title: Supplementary Material for: Transbronchial Cryobiopsies for Diagnosing Interstitial Lung Disease: Real-Life Experience from a Tertiary Referral Center for Interstitial Lung Disease

description: <b><i>Background:</i></b> Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported. <b><i>Objectives:</i></b> We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. <b><i>Methods:</i></b> Data on all patients undergoing a cTBB for evaluation of suspected ILD between October 2015 and January 2017 were included in this retrospective case series. Procedure details, complication rates, histopathological results, and diagnostic consensus reached by a multidisciplinary team (MDT) discussion were collated and evaluated. <b><i>Results:</i></b> A total of 109 patients (mean age 64 years, range 19–85; 66% male, 38% never smokers) referred to our center with features suggestive of ILD underwent cTBB. The mean FVC% predicted was 77% (range 41–131), with a mean DLCO of 51% (range 20–86), and a 6-min walking test (6MWT) of 402 m (range 100–642). On average, 4 samples were taken from each patient (range 1–8), with a mean biopsy diameter of 5 mm (range 2–12). Complications included pneumothorax (11.9%), all treated with chest drain. Moderate bleeding occurred in 28.4% (all resolved without active measures). No acute disease exacerbations and no deaths occurred. A histopathological pattern diagnosis was possible in 80 cases (73.4%), and 26.6% of cases were considered nonspecific. An MDT consensus diagnosis was reached in 83.5% of cases. Subsequent SLB was proposed in 13 cases and performed in 8 cases. <b><i>Conclusions:</i></b> In the real-world setting, cTBB has a meaningful diagnostic value in the context of a MDT approach and may enable histopathological assessment even in patients with more advanced disease unsuitable for SLB.
DOI: 10.6084/m9.figshare.7466723
title: 20V_INPUT

description: 20V_INPUT
DOI: 10.7284/118188
title: Singlebeam Echosounder data collected during research cruise MGL1512 using a Knudsen 3260 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7466702
title: 20V_K4ME1

description: 20V_K4ME1
DOI: 10.6084/m9.figshare.7466708.v1
title: Supplementary Material for: Transbronchial Cryobiopsies for Diagnosing Interstitial Lung Disease: Real-Life Experience from a Tertiary Referral Center for Interstitial Lung Disease

description: <b><i>Background:</i></b> Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported. <b><i>Objectives:</i></b> We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. <b><i>Methods:</i></b> Data on all patients undergoing a cTBB for evaluation of suspected ILD between October 2015 and January 2017 were included in this retrospective case series. Procedure details, complication rates, histopathological results, and diagnostic consensus reached by a multidisciplinary team (MDT) discussion were collated and evaluated. <b><i>Results:</i></b> A total of 109 patients (mean age 64 years, range 19–85; 66% male, 38% never smokers) referred to our center with features suggestive of ILD underwent cTBB. The mean FVC% predicted was 77% (range 41–131), with a mean DLCO of 51% (range 20–86), and a 6-min walking test (6MWT) of 402 m (range 100–642). On average, 4 samples were taken from each patient (range 1–8), with a mean biopsy diameter of 5 mm (range 2–12). Complications included pneumothorax (11.9%), all treated with chest drain. Moderate bleeding occurred in 28.4% (all resolved without active measures). No acute disease exacerbations and no deaths occurred. A histopathological pattern diagnosis was possible in 80 cases (73.4%), and 26.6% of cases were considered nonspecific. An MDT consensus diagnosis was reached in 83.5% of cases. Subsequent SLB was proposed in 13 cases and performed in 8 cases. <b><i>Conclusions:</i></b> In the real-world setting, cTBB has a meaningful diagnostic value in the context of a MDT approach and may enable histopathological assessment even in patients with more advanced disease unsuitable for SLB.
DOI: 10.6084/m9.figshare.7466714
title: Supplementary Material for: Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4–5 and those established on haemodialysis (G5D). <b><i>Methods:</i></b> Ninety participants with CKD G4–5D were recruited from Nephrology Outpatient Clinics and 2 Haemodialysis Units between December 2016 and December 2017. Frailty was diagnosed using the Fried Frailty Phenotype. The following frailty screening tests were evaluated: Clinical Frailty Scale, PRISMA-7, CKD Frailty Index, CKD FI-LAB, walking speed, hand grip strength and Short Physical Performance Battery. <b><i>Results:</i></b> The mean age of participants was 69 years (SD ±13). One-third of participants were dialysis-dependent. Nineteen (21%) patients were categorised as frail, 42 (47%) as pre-frail and 29 (32%) as robust. Overall, walking speed was the most discriminative measure (AUC 0.97 [95% CI 0.93–1.00], sensitivity 0.84 [95% CI 0.62–0.94], specificity 0.96 [95% CI 0.88–0.99]). The Clinical Frailty Scale had the best performance of the non-physical assessment frailty screening methods (AUC 0.90 [95% CI 0.84–0.97], sensitivity 0.79 [95% CI 0.57–0.91], specificity 0.87 [95% CI 0.78–0.93]). <b><i>Conclusions:</i></b> Walking speed can be used to accurately screen for frailty in CKD populations. If it is not practical to perform a physical assessment to screen for frailty, the Clinical Frailty Scale is a useful alternative.
DOI: 10.6084/m9.figshare.7466723.v1
title: 20V_INPUT

description: 20V_INPUT
DOI: 10.6084/m9.figshare.7466684
title: 20V_K27AC

description: 20V_K27AC
DOI: 10.6084/m9.figshare.7466702.v1
title: 20V_K4ME1

description: 20V_K4ME1
DOI: 10.6084/m9.figshare.7466714.v2
title: Supplementary Material for: Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4–5 and those established on haemodialysis (G5D). <b><i>Methods:</i></b> Ninety participants with CKD G4–5D were recruited from Nephrology Outpatient Clinics and 2 Haemodialysis Units between December 2016 and December 2017. Frailty was diagnosed using the Fried Frailty Phenotype. The following frailty screening tests were evaluated: Clinical Frailty Scale, PRISMA-7, CKD Frailty Index, CKD FI-LAB, walking speed, hand grip strength and Short Physical Performance Battery. <b><i>Results:</i></b> The mean age of participants was 69 years (SD ±13). One-third of participants were dialysis-dependent. Nineteen (21%) patients were categorised as frail, 42 (47%) as pre-frail and 29 (32%) as robust. Overall, walking speed was the most discriminative measure (AUC 0.97 [95% CI 0.93–1.00], sensitivity 0.84 [95% CI 0.62–0.94], specificity 0.96 [95% CI 0.88–0.99]). The Clinical Frailty Scale had the best performance of the non-physical assessment frailty screening methods (AUC 0.90 [95% CI 0.84–0.97], sensitivity 0.79 [95% CI 0.57–0.91], specificity 0.87 [95% CI 0.78–0.93]). <b><i>Conclusions:</i></b> Walking speed can be used to accurately screen for frailty in CKD populations. If it is not practical to perform a physical assessment to screen for frailty, the Clinical Frailty Scale is a useful alternative.
DOI: 10.7284/118187
title: Speedlog data collected during research cruise MGL1512 using a Furuno DS-50 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7466663
title: N44 version by Knut

description: This is the version of the Nordic power system used by Knut
DOI: 10.6084/m9.figshare.7466684.v1
title: 20V_K27AC

description: 20V_K27AC
DOI: 10.6084/m9.figshare.7466714.v1
title: Supplementary Material for: Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease

description: <b><i>Background/Aims:</i></b> Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4–5 and those established on haemodialysis (G5D). <b><i>Methods:</i></b> Ninety participants with CKD G4–5D were recruited from Nephrology Outpatient Clinics and 2 Haemodialysis Units between December 2016 and December 2017. Frailty was diagnosed using the Fried Frailty Phenotype. The following frailty screening tests were evaluated: Clinical Frailty Scale, PRISMA-7, CKD Frailty Index, CKD FI-LAB, walking speed, hand grip strength and Short Physical Performance Battery. <b><i>Results:</i></b> The mean age of participants was 69 years (SD ±13). One-third of participants were dialysis-dependent. Nineteen (21%) patients were categorised as frail, 42 (47%) as pre-frail and 29 (32%) as robust. Overall, walking speed was the most discriminative measure (AUC 0.97 [95% CI 0.93–1.00], sensitivity 0.84 [95% CI 0.62–0.94], specificity 0.96 [95% CI 0.88–0.99]). The Clinical Frailty Scale had the best performance of the non-physical assessment frailty screening methods (AUC 0.90 [95% CI 0.84–0.97], sensitivity 0.79 [95% CI 0.57–0.91], specificity 0.87 [95% CI 0.78–0.93]). <b><i>Conclusions:</i></b> Walking speed can be used to accurately screen for frailty in CKD populations. If it is not practical to perform a physical assessment to screen for frailty, the Clinical Frailty Scale is a useful alternative.
DOI: 10.6084/m9.figshare.7466660
title: 20V_POL2

description: 20v pol2
DOI: 10.6084/m9.figshare.7466645
title: Evaluation results

description: Evaluation results for publication "Reducing inter-observer variability and interaction time of MR liver volumetry by combining automatic CNN-based liver segmentation and manual corrections"
DOI: 10.6084/m9.figshare.7466648
title: Data Set 1: Live cell microscopy videos of cellular distribution of PTEN:EGFP and PTEN-L:EGFP after 50µM glutamate stress in mouse primary neurons (Fig. 3a-b)

description: This dataset contains 8 live cell microscopy timelapse video files in <b>.avi</b> format. The imaging targets murine primary neurons using enhanced green fluorescent protein (EGFP).<br>The related study investigates the function and regulation of PTEN-L in neurons in the context of brain ischemia. Exogenous, EGFP-tagged PTEN-L or the shorter variant PTEN were expressed in primary neurons after knock out of endogenous PTEN. Oxygen-glucose deprivation or exposure to 50 µM glutamate were applied to neurons to test their response to ischemic-like stress.<br><b>Methods</b><br>Cells expressing PTEN:EGFP or PTEN-L:EGFP were imaged every 10 min for 90 min. The time-lapse movies compiled from the 90 min observation. Primary neurons derived from conditional PTEN knockout mice were transduced with both <i>Cre</i>-delivering lentiviral particles (LVPs) or control LVPs and <i>Pten</i>-delivering LVPs or control LVPs as described above and seeded in 8-well microscopy dishes (Ibidi). DIV 9 primary neurons were imaged while maintaining culturing conditions (20 % oxygen, 5 % CO<sub>2</sub> and 37°C). A confocal microscope (Nikon Ti2) with uniform spinning disk illumination (Andor Borealis), an EMCCD Camera (iXon3 DU-888 Ultra) and 60x Plan Apo oil objective (Nikon) was used to acquire images. 8 positions across 4 wells were selected and images of z-planes (30 - 40 µM with 1 µM intervals) were taken with a laser exciting at 488 nm (&gt;8 mW; 20 %) detecting EGFP and a laser exciting at 561 nm (&gt;15 mW; 9 %) detecting mCherry. Next, cells were treated with 50 µM glutamate and each position was imaged every 10 min for 90 min using above described settings. Fiji software was used to compile time lapse videos over the 90 min observation period. <br>
DOI: 10.6084/m9.figshare.7466648.v1
title: Data Set 1: Live cell microscopy videos of cellular distribution of PTEN:EGFP and PTEN-L:EGFP after 50µM glutamate stress in mouse primary neurons (Fig. 3a-b)

description: This dataset contains 8 live cell microscopy timelapse video files in <b>.avi</b> format. The imaging targets murine primary neurons using enhanced green fluorescent protein (EGFP).<br>The related study investigates the function and regulation of PTEN-L in neurons in the context of brain ischemia. Exogenous, EGFP-tagged PTEN-L or the shorter variant PTEN were expressed in primary neurons after knock out of endogenous PTEN. Oxygen-glucose deprivation or exposure to 50 µM glutamate were applied to neurons to test their response to ischemic-like stress.<br><b>Methods</b><br>Cells expressing PTEN:EGFP or PTEN-L:EGFP were imaged every 10 min for 90 min. The time-lapse movies compiled from the 90 min observation. Primary neurons derived from conditional PTEN knockout mice were transduced with both <i>Cre</i>-delivering lentiviral particles (LVPs) or control LVPs and <i>Pten</i>-delivering LVPs or control LVPs as described above and seeded in 8-well microscopy dishes (Ibidi). DIV 9 primary neurons were imaged while maintaining culturing conditions (20 % oxygen, 5 % CO<sub>2</sub> and 37°C). A confocal microscope (Nikon Ti2) with uniform spinning disk illumination (Andor Borealis), an EMCCD Camera (iXon3 DU-888 Ultra) and 60x Plan Apo oil objective (Nikon) was used to acquire images. 8 positions across 4 wells were selected and images of z-planes (30 - 40 µM with 1 µM intervals) were taken with a laser exciting at 488 nm (&gt;8 mW; 20 %) detecting EGFP and a laser exciting at 561 nm (&gt;15 mW; 9 %) detecting mCherry. Next, cells were treated with 50 µM glutamate and each position was imaged every 10 min for 90 min using above described settings. Fiji software was used to compile time lapse videos over the 90 min observation period. <br>
DOI: 10.6084/m9.figshare.7466660.v1
title: 20V_POL2

description: 20v pol2
DOI: 10.7284/118191
title: TSG (Thermosalinograph) data collected during research cruise MGL1512 using a Sea-Bird SBE-21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7466642
title: Science Podcast Database from Science podcasts: analysis of global production and output from 2004 to 2018

description: Excel spreadsheet containing all information used in this study of science podcasts.
DOI: 10.7284/122391
title: Expendable Probe data collected during research cruise MGL1514 using a Sippican MK21 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7466627
title: Supplementary Material from Nonlinear scaling effects in the stiffness of soft cellular structures

description: Summary of all data presented within the paper to create the figures.
DOI: 10.6084/m9.figshare.7466630
title: N44 version by Sigurd

description: This version of the Model is based upon Silje's version, but uses the tuning from Knut's version
DOI: 10.6084/m9.figshare.7466624
title: Supplementary Material 2 from Nonlinear scaling effects in the stiffness of soft cellular structures

description: Additional material generated as part of the manuscript revision process
DOI: 10.7284/122396
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1514 using a C&C C-Nav 3050 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7466624.v1
title: Supplementary Material 2 from Nonlinear scaling effects in the stiffness of soft cellular structures

description: Additional material generated as part of the manuscript revision process
DOI: 10.6084/m9.figshare.7466627.v1
title: Supplementary Material from Nonlinear scaling effects in the stiffness of soft cellular structures

description: Summary of all data presented within the paper to create the figures.
DOI: 10.6084/m9.figshare.7466618
title: Taxonomy and operational identification of Quaternary species of <i>Spiniferites</i> and related genera

description: In this article, we are proposing an Identification Key for recognition of Quaternary <i>Spiniferites</i> species and some morphologically close Quaternary taxa of some related genera. We summarize the morphological features of 43 taxa (including three subspecies and one variety) based on the original description of the holotypes and sometimes supplemented by our observations. In addition to the Identification Key, we refer to published illustrations that feature both typical and atypical specimens for each taxon. The compilation of this key gave us the opportunity to reconsider some taxonomic concepts, which resulted in two new combinations and an emendation: <i>Hafniasphaera granulata</i> (Mao 1989) comb. nov., emend. and <i>Hafniasphaera multisphaera</i> (Price and Pospelova 2014) comb. nov. In addition, we recommend that the names <i>Spiniferites nodosus</i> and <i>Spiniferites pseudofurcatus</i> subsp. <i>obliquus</i> be restricted to their holotype.
DOI: 10.6084/m9.figshare.7466618.v1
title: Taxonomy and operational identification of Quaternary species of <i>Spiniferites</i> and related genera

description: In this article, we are proposing an Identification Key for recognition of Quaternary <i>Spiniferites</i> species and some morphologically close Quaternary taxa of some related genera. We summarize the morphological features of 43 taxa (including three subspecies and one variety) based on the original description of the holotypes and sometimes supplemented by our observations. In addition to the Identification Key, we refer to published illustrations that feature both typical and atypical specimens for each taxon. The compilation of this key gave us the opportunity to reconsider some taxonomic concepts, which resulted in two new combinations and an emendation: <i>Hafniasphaera granulata</i> (Mao 1989) comb. nov., emend. and <i>Hafniasphaera multisphaera</i> (Price and Pospelova 2014) comb. nov. In addition, we recommend that the names <i>Spiniferites nodosus</i> and <i>Spiniferites pseudofurcatus</i> subsp. <i>obliquus</i> be restricted to their holotype.
DOI: 10.7284/122400
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGL1514 using a C&C C-Nav 2000 instrument system onboard the platform RV Marcus G. Langseth

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7466588
title: Supplementary Material for: Association between Freestanding Dialysis Facility Size and Medicare Quality Incentive Program Performance Scores

description: <b><i>Background:</i></b> Medicare uses a quality incentive program (QIP) criteria to evaluate care in dialysis facilities and apply monetary penalties on underperforming facilities. Smaller dialysis facilities are likely to be rural and operate on lower profit margin; therefore, such facilities are likely to underperform and face Medicare penalties. The variation in QIP scores by facility size is not yet known. We investigated the association between freestanding dialysis facility size and QIP scores. <b><i>Methods:</i></b> Our cross-sectional analysis compared QIP scores across levels of facility size for 5,193 freestanding dialysis facilities that received QIP scores in 2015. We used Medicare facility data including Dialysis Facility Compare, Performance Scores, Facility-Level Impact, and Area Health Resource and United States Renal Data System files for the payment year 2015. We measured the facility size using the number of dialysis stations per dialysis facility. QIP scores were used to determine the quality of care. A generalized linear model was estimated at an alpha level of 0.05. <b><i>Results:</i></b> Facilities operating more than 10 dialysis stations scored higher than those operating fewer. Further, facilities in the South and Northeast, not offering peritoneal dialysis, affiliated with chains (except chain 3) and spending more hours per dialysis achieved higher QIP scores. Facilities reporting a higher proportion of Hispanic patients and of patients with access to pre-end-stage renal disease (ESRD) nephrologist care achieved higher QIP scores. Conversely, facilities with a higher Black patient population and higher patient travel distances scored lower. <b><i>Conclusions:</i></b> The current study provides important finding about the performance of the dialysis facilities with ≤10 dialysis stations. Quality improvement strategies are needed, especially for the dialysis facilities with ≤10 stations, to prevent penalties and eventual closure of such facilities due to financial insolvency. Failure to address these issues will increase further disparities in ESRD care.