cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7090499
title: EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in Desmoplastic Small Round Cell Tumors

description: EWS fusion oncoproteins underlie the pathogenesis of several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive mesenchymal tumor driven by fusions between the disordered domain of EWS and the developmental transcription factor WT1. Here we combined chromatin occupancy and long-range interaction profiles to identify EWS-WT1-dependent gene regulation networks and directly controlled target genes. We show that EWS-WT1 operates primarily as a powerful activator of distal regulatory elements and controls an oncogenic gene expression program that characterize primary DSRCTs. Moreover, EWS-WT1 has two isoforms that differ by three amino acids in their DNA binding domain (+/- KTS), as observed for wild type WT1, and we show that each fusion isoform has a specific DNA binding profile that is distinct from its wild type counterparts and requires a functional EWSR1 prion like domain. Remarkably, xenograft experiments using human mesothelial cells, candidate cells of origin of DSRCT, reveal that both isoforms are required to generate viable tumors that resemble DSRCT. Finally, we identify new candidate EWS-WT1 target genes with potential therapeutic implications, including <em>CCND1</em>, whose inhibition by the clinically-approved drug Palbociclib leads to marked tumor burden decrease in DSRCT PDXs <em>in vivo</em>. Taken together, our studies identify gene regulation programs and therapeutic vulnerabilities in DSRCT and provide a mechanistic understanding of the complex isoform-dependent oncogenic activity of EWS-WT1.
DOI: 10.6084/m9.figshare.21153355
title: IJPR furniture data.sav

description: IJPR data for the Chinese furniture indstry
DOI: 10.6084/m9.figshare.21153355.v1
title: IJPR furniture data.sav

description: IJPR data for the Chinese furniture indstry
DOI: 10.6085/aa/pisco_recruitment.158.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.159.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1990

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.160.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.161.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1991

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.162.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.163.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1992

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.164.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.165.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1993

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.166.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.167.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1994

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.168.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.169.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1995

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.170.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.171.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1996

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.172.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.173.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1998

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.174.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.175.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 1999

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.176.1
title: (:unkn)
DOI: 10.6085/aa/pisco_recruitment.177.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 2000

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.179.1
title: PISCO: Intertidal: Recruitment Monitoring: OSU: Plate: 2001

description: This metadata record documents the recruitment monitoring study for PISCO intertidal. Settlement collectors are deployed and rock surfaces cleared at various sites along the pacific coast of California and Oregon. At each site there are at least two types of collectors. Collectors made of plastic mesh, ovoid, pot-scrubbers ("Tuffys") target mussel recruits. Plastic 10x10 cm PVC plates covered with 3M Safety-Walk target barnacle recruitment. 10x10 cm square plots were cleared on the rock near each barnacle recruitment plate to target natural barnacle recruitment. Turfys are rectangles of artificial turf that target crab recruitment. All collectors were deployed and plots cleared in the mid zone at all the sites throughout the year. Additional collectors and plots were added to the low and high shore levels in specific years and sites. Although mussels and barnacles were the main target taxa, other organisms were recorded as well.
DOI: 10.6085/aa/pisco_recruitment.180.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20070109.50.6
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-01-09. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 0.1 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.40.2
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-04-05. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 0.1 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.50.2
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-04-05. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 0.1 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.50.3
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-04-05. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 0.1 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.50.4
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-04-05. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 0.1 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070405.50.5
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-04-05. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 0.1 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070701.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20070701.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-07-01. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20070917.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20070917.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-09-17. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20071213.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20071213.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2007-12-13. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20080304.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20080304.40.2
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20080304.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2008-03-04. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20080304.50.2
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using an RDI 600 kHz Workhorse Sentinel ADCP beginning 2008-03-04. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20080304.50.3
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2008-03-04. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20080602.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20080602.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2008-06-02. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20080828.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20080828.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2008-08-28. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20081118.40.1
title: (:unkn)
DOI: 10.6085/aa/tpt001_018adcp018r00_20081118.50.1
title: PISCO: Physical Oceanography: bottom-mounted ADCP data: Terrace Point, California, USA (TPT001)

description: This metadata record describes bottom-mounted ADCP data collected at Terrace Point, California, USA, by PISCO. Measurements were collected using a RDI 600 kHz Workhorse Sentinel ADCP beginning 2008-11-18. The instrument depth was 018 meters, in an overall water depth of 18 meters (both relative to Mean Sea Level, MSL). The instrument was programmed with a sampling interval of 2.0 minutes and a vertical resolution of 1 meter.
DOI: 10.6085/aa/tpt001_018adcp018r00_20090213.40.1
title: (:unkn)