cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24936714
title: Supplementary materials: Review and estimation of disutility for joint health states of severe and non-severe hypoglycemic events in diabetes

description: <b>These are peer-reviewed supplementary materials for the arti</b><b>cle '</b><b>Review and estimation of disutility for joint health states of severe and nonsevere hypoglycemic events in diabetes</b><b>' p</b><b>ublished in the </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b><b>Supplementary Material 1</b>: Literature Search Strategies<b>Supplementary Material 2</b>: Methods of estimating disutility of the joint four health states: daytime NSHE, nocturnal NSHE, daytime SHE, and nocturnal SHE<b>Supplementary Material 3</b>: Estimation of Disutility for Joint Two Health States of SHEs and NSHEs<b>Supplementary Material 4</b>: Disutility Data for Construct Validity<b>Supplementary Material 5</b>: Details of Studies Included in Literature Review<b>Summary: </b><b>Aim:</b> Many economic evaluations used linear or log-transformed additive methods to estimate the disutility of hypoglycemic events in diabetes, both nonsevere (NSHEs) and severe (SHEs). <b>Methods:</b> We conducted a literature search for studies of disutility for hypoglycemia. We used additive, minimum and multiplicative methods, and the adjusted decrement estimator to estimate the disutilities of joint health states with both NSHEs and SHEs in six scenarios. <b>Results:</b> Twenty-four studies reported disutilities for hypoglycemia in diabetes. Based on construct validity, the adjusted decrement estimator method likely provides less biased estimates, predicting that when SHEs occur, the additional impact from NSHEs is marginal. <b>Conclusion:</b> Our proposed new method provides a different perspective on the estimation of quality-adjusted life-years in economic evaluations of hypoglycemic treatments.
DOI: 10.6084/m9.figshare.24936714.v1
title: Supplementary materials: Review and estimation of disutility for joint health states of severe and non-severe hypoglycemic events in diabetes

description: <b>These are peer-reviewed supplementary materials for the arti</b><b>cle '</b><b>Review and estimation of disutility for joint health states of severe and nonsevere hypoglycemic events in diabetes</b><b>' p</b><b>ublished in the </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b><b>Supplementary Material 1</b>: Literature Search Strategies<b>Supplementary Material 2</b>: Methods of estimating disutility of the joint four health states: daytime NSHE, nocturnal NSHE, daytime SHE, and nocturnal SHE<b>Supplementary Material 3</b>: Estimation of Disutility for Joint Two Health States of SHEs and NSHEs<b>Supplementary Material 4</b>: Disutility Data for Construct Validity<b>Supplementary Material 5</b>: Details of Studies Included in Literature Review<b>Summary: </b><b>Aim:</b> Many economic evaluations used linear or log-transformed additive methods to estimate the disutility of hypoglycemic events in diabetes, both nonsevere (NSHEs) and severe (SHEs). <b>Methods:</b> We conducted a literature search for studies of disutility for hypoglycemia. We used additive, minimum and multiplicative methods, and the adjusted decrement estimator to estimate the disutilities of joint health states with both NSHEs and SHEs in six scenarios. <b>Results:</b> Twenty-four studies reported disutilities for hypoglycemia in diabetes. Based on construct validity, the adjusted decrement estimator method likely provides less biased estimates, predicting that when SHEs occur, the additional impact from NSHEs is marginal. <b>Conclusion:</b> Our proposed new method provides a different perspective on the estimation of quality-adjusted life-years in economic evaluations of hypoglycemic treatments.
DOI: 10.5255/ukda-sn-856652
title: Optimal Categorisation: The Origin and Nature of Gender From a Psycholinguistic Perspective, 2018-2023

description: As part of the attempt to understand the linguistic origin and cognitive nature of grammatical gender, we designed six psycholinguistic experiments for our language sample from Vanuatu (Merei, Lewo, Vatlongos, North Ambrym) and New Caledonia (Nêlêmwa, Iaai). Each language differs in number of classifiers, and whether nouns can freely occur with different classifiers, or are restricted to just one classifier (similar to grammatical gender).

Free-listing: participants heard a possessive classifier and listed associated nouns. This revealed the different semantic domains of classifiers, the salient nouns associated with each classifier, and showed whether participants listed the same noun with different classifiers.

Card-sorting: Participants free-sorted sixty images, followed by a structured sort according to which classifier they used with each picture. We compared whether similar piles were made across sorting tasks to reveal whether the linguistic classification system provides a structure for general cognition. 

Video-vignettes: Participants described 24 video clips which showed different interactions between an actor and their possession, evoking a classifier. This tested both typical and atypical interactions to see if the same or different classifiers were used.

Possessive-labelling: Participants heard 140 nouns in their language and responded by saying the item belonged to them, which meant using a classifier. This measured* inter-speaker variation in the use of classifiers for particular items, reaction times and inter-speaker variation for different possessions.

Storyboards: eight four-picture storyboards were presented to participants. We recorded participant responses, uncovering if the same classifier was used in consecutive parts of the larger story and whether the classifiers were used anaphorically. 

Eye-tracking: eight line-drawn pictures were combined in a paired-preference design. An eye tracker recorded fixation times. Participants heard the auditory cue of a classifier before being presented with a pair of images. This provided objective measures of automatic processing to identify patterns in attention.
DOI: 10.25345/c5sq8qv0t
title: MassIVE MSV000093756 - Catabolic pathway acquisition by soil pseudomonads readily enables growth with salicyl alcohol but does not affect colonization of Populus roots
title: Horizontal gene transfer (HGT) is a fundamental evolutionary process that plays a key role in bacterial evolution. The likelihood of a successful transfer event is expected to depend on the precise balance of costs and benefits resulting from pathway acquisition. Most experimental analyses of HGT have focused on phenotypes that have large fitness benefits under appropriate selective conditions, such as antibiotic resistance. However, many examples of HGT involve phenotypes that are predicted to provide smaller benefits, such as the ability to catabolize additional carbon sources. We have experimentally reproduced one such HGT event in the laboratory, studying the effects of transferring a pathway for catabolism of the plant-derived aromatic compound salicyl alcohol into soil isolates from the Pseudomonas genus. We find that pathway acquisition enables rapid catabolism of salicyl alcohol with only minor disruptions to existing metabolic and regulatory networks of the new host. However, this new catabolic potential does not confer a measurable fitness advantage during competitive growth in the rhizosphere. We conclude that the phenotype of salicyl alcohol catabolism is readily transferred by HGT but is selectively neutral under environmentally-relevant conditions. We propose that this condition is common and that HGT of many pathways will be self-limiting because the selective benefits are small and negative frequency-dependent.
DOI: 10.25345/c5nz8115c
title: MassIVE MSV000093757 - Alteration of proteome by MASTL inhibition in gastric cancer cells
title: Alteration of proteome by MASTL inhibition in gastric cancer cells
DOI: 10.6084/m9.figshare.24936825
title: Supplementary Material for: NODDING SYNDROME: A SYSTEMATIC REVIEW

description: Introduction: Nodding Syndrome (NS) remains a poorly understood disorder. For a long time, it has been thought to be restricted to East Africa, however cases in Central Africa have been increasing over time. The objective of this systematic review (SR) was to provide a summary of the state of knowledge on NS to date.
Methods: All original articles published on NS up to November 2021 were searched in four major databases and in the grey literature. Commentaries, editorials, book chapters, books, conference paper, qualitative studies that mentioned NS cases were also included. Data retrieved included study location, year of study and of publication, population characteristics, definition and diagnosis of NS, associated factors, and treatment if applicable. A meta-analysis of associated factors was performed where possible and results were presented as Odds Ratios and visualized as Forrest Plots. Geographic information systems were used for cartographic representations. The quality of the articles included was assessed.
Results: Of the 876 articles initially identified, 67 (corresponding to 59 studies) were included in the SR. NS is only present in Central and East Africa. Interestingly, there were reports of NS in Central Africa prior to 2010, earlier than previously thought. The way NS diagnosis was established varies according to studies, and the 2012 WHO classification was used in only 60% of the studies. Approximately 11% of the articles did not meet the quality requirements set for this review. In our meta-analysis, the main factor associated with NS was onchocerciasis (OR = 8.8 [4.8, 15.9]). However, the pathophysiology of the disease remains poorly understood. The lack of common antiepileptic drugs is a significant barrier for the management of head nodding and associated epileptic seizures. 
Discussion/conclusion: The lack of an operational definition of NS is an obstacle to its diagnosis and thus to its appropriate treatment. Indeed, diagnostic difficulties might have led to false positives and false negatives which could have altered the picture of NS presented in this article. Treatment should take into account nutritional and psychological factors, as well as associated infections. Some risk factors deserve further investigation; therefore, we suggest a multicentric study with an etiological focus using a more operational definition of NS.
DOI: 10.6084/m9.figshare.24936825.v1
title: Supplementary Material for: NODDING SYNDROME: A SYSTEMATIC REVIEW

description: Introduction: Nodding Syndrome (NS) remains a poorly understood disorder. For a long time, it has been thought to be restricted to East Africa, however cases in Central Africa have been increasing over time. The objective of this systematic review (SR) was to provide a summary of the state of knowledge on NS to date.
Methods: All original articles published on NS up to November 2021 were searched in four major databases and in the grey literature. Commentaries, editorials, book chapters, books, conference paper, qualitative studies that mentioned NS cases were also included. Data retrieved included study location, year of study and of publication, population characteristics, definition and diagnosis of NS, associated factors, and treatment if applicable. A meta-analysis of associated factors was performed where possible and results were presented as Odds Ratios and visualized as Forrest Plots. Geographic information systems were used for cartographic representations. The quality of the articles included was assessed.
Results: Of the 876 articles initially identified, 67 (corresponding to 59 studies) were included in the SR. NS is only present in Central and East Africa. Interestingly, there were reports of NS in Central Africa prior to 2010, earlier than previously thought. The way NS diagnosis was established varies according to studies, and the 2012 WHO classification was used in only 60% of the studies. Approximately 11% of the articles did not meet the quality requirements set for this review. In our meta-analysis, the main factor associated with NS was onchocerciasis (OR = 8.8 [4.8, 15.9]). However, the pathophysiology of the disease remains poorly understood. The lack of common antiepileptic drugs is a significant barrier for the management of head nodding and associated epileptic seizures. 
Discussion/conclusion: The lack of an operational definition of NS is an obstacle to its diagnosis and thus to its appropriate treatment. Indeed, diagnostic difficulties might have led to false positives and false negatives which could have altered the picture of NS presented in this article. Treatment should take into account nutritional and psychological factors, as well as associated infections. Some risk factors deserve further investigation; therefore, we suggest a multicentric study with an etiological focus using a more operational definition of NS.
DOI: 10.5281/zenodo.10421588
title: Abundance of Eukaryotic Microorganisms, their Ice Nucleating Macromolecule Concentrations and those of Standard Polysaccharides

description: Dataset associated with the publication Hartmann, Schrödner, Zeppenfeld et al. (2024): "Marine Polysaccharides – Major Contributor to Ice Nucleating Particles in Remote Marine Regions". The dataset includes the relative abundance of eukaryotic microorganisms collected between 19th till 24th of November 2017 around Svalbard onboard R/V Helmer Hanssen during polar night cruise. Further, the dataset presents the number concentration of ice nucleating macromolecules of selected eukaryotic microorganisms and standard polysaccharides. For further details see publication.
DOI: 10.5281/zenodo.10421589
title: Abundance of Eukaryotic Microorganisms, their Ice Nucleating Macromolecule Concentrations and those of Standard Polysaccharides

description: Dataset associated with the publication Hartmann, Schrödner, Zeppenfeld et al. (2024): "Marine Polysaccharides – Major Contributor to Ice Nucleating Particles in Remote Marine Regions". The dataset includes the relative abundance of eukaryotic microorganisms collected between 19th till 24th of November 2017 around Svalbard onboard R/V Helmer Hanssen during polar night cruise. Further, the dataset presents the number concentration of ice nucleating macromolecules of selected eukaryotic microorganisms and standard polysaccharides. For further details see publication.
DOI: 10.6084/m9.figshare.24936828
title: Supplementary Material for: Protective effect of glutathione administration on ovarian function in female rats with cyclophosphamide-induced ovarian damage

description: Objectives:
We investigated the potential of glutathione to protect ovarian function in rats exposed to cyclophosphamide by measuring serum anti-Mullerian hormone levels, follicle counts, and related parameters. 
Design:
Forty-two adult female Sprague-Dawley rats were randomly divided into six groups and treated with various combinations of cyclophosphamide, glutathione, and sodium chloride. On day 21, the rats were anaesthetized, and their ovaries were removed for examination. 
Participants/Materials, Setting, Methods:
Histopathological examination, serum anti-Mullerian hormone (AMH) concentrations, follicle counts, anti-Mullerian hormone-positive staining of follicle percentages were analyzed. Statistical analysis was performed using a one-way analysis of variance and Tukey’s test, with significance set at p&lt;0.05. 
Primary evaluations included serum anti-Mullerian hormone concentrations and ovarian follicle counts. Secondary measures encompassed histopathological examination and percentages of anti-Mullerian hormone-positive staining of follicles.
Results
Significant differences were observed in follicle counts, anti-Mullerian hormone-positive follicle parameters, and serum anti-Mullerian hormone concentrations among the six groups. Group 2 (treated with cyclophosphamide) had the lowest primordial, primary, secondary, and antral follicle counts and the highest atretic count. Group 6, treated with cyclophosphamide and 200 mg/kg glutathione, showed improved follicle counts compared to those in group 2. Reducing the glutathione dose to 100 mg/kg was ineffective. 
Limitations
This was an experimental animal investigation with a comparatively modest sample size. Experimental studies should be conducted to determine the optimal dosage and duration of glutathione therapy. Information gathered from an experimental animal model may not yield precisely similar outcomes in humans; therefore, additional investigations are necessary to examine the impact of glutathione on women experiencing POI. 
Conclusions
The anti-oxidative protective effect of directly administered glutathione was demonstrated for the first time. Low-dose glutathione was ineffective, whereas a high dose yielded significant ovarian protection against cyclophosphamide. Our findings provide valuable insights for supplementing clinical trials on the protective effects of glutathione against ovarian damage.
DOI: 10.6084/m9.figshare.24936828.v1
title: Supplementary Material for: Protective effect of glutathione administration on ovarian function in female rats with cyclophosphamide-induced ovarian damage

description: Objectives:
We investigated the potential of glutathione to protect ovarian function in rats exposed to cyclophosphamide by measuring serum anti-Mullerian hormone levels, follicle counts, and related parameters. 
Design:
Forty-two adult female Sprague-Dawley rats were randomly divided into six groups and treated with various combinations of cyclophosphamide, glutathione, and sodium chloride. On day 21, the rats were anaesthetized, and their ovaries were removed for examination. 
Participants/Materials, Setting, Methods:
Histopathological examination, serum anti-Mullerian hormone (AMH) concentrations, follicle counts, anti-Mullerian hormone-positive staining of follicle percentages were analyzed. Statistical analysis was performed using a one-way analysis of variance and Tukey’s test, with significance set at p&lt;0.05. 
Primary evaluations included serum anti-Mullerian hormone concentrations and ovarian follicle counts. Secondary measures encompassed histopathological examination and percentages of anti-Mullerian hormone-positive staining of follicles.
Results
Significant differences were observed in follicle counts, anti-Mullerian hormone-positive follicle parameters, and serum anti-Mullerian hormone concentrations among the six groups. Group 2 (treated with cyclophosphamide) had the lowest primordial, primary, secondary, and antral follicle counts and the highest atretic count. Group 6, treated with cyclophosphamide and 200 mg/kg glutathione, showed improved follicle counts compared to those in group 2. Reducing the glutathione dose to 100 mg/kg was ineffective. 
Limitations
This was an experimental animal investigation with a comparatively modest sample size. Experimental studies should be conducted to determine the optimal dosage and duration of glutathione therapy. Information gathered from an experimental animal model may not yield precisely similar outcomes in humans; therefore, additional investigations are necessary to examine the impact of glutathione on women experiencing POI. 
Conclusions
The anti-oxidative protective effect of directly administered glutathione was demonstrated for the first time. Low-dose glutathione was ineffective, whereas a high dose yielded significant ovarian protection against cyclophosphamide. Our findings provide valuable insights for supplementing clinical trials on the protective effects of glutathione against ovarian damage.
DOI: 10.6073/pasta/3901addcd63d77aedafa2bfd924b73cb
title: Harvard Forest Summer Research Program in Ecology Alumni Survey 2013-2015

description: Program Context
 Since its inception in 1985, when a single undergraduate worked on a study of old-growth forests, the Harvard Forest Summer Research Program in Ecology (HF-SRPE) has developed into a thriving and well-coordinated program that is central to the educational and research mission of the biological field station. With core support since 1993 from a succession of NSF REU Site awards and NSF REU supplements, and with additional funding from Harvard University, HF-SRPE has grown to support 20-30 undergraduate students annually. Students are mentored by principle investigators and senior scientists in conducting research in ecology, soil science, paleoecology, wildlife biology, conservation biology, and atmospheric sciences.
 The research conducted by our HF-SRPE students contributes substantially to long-term scientific investigations supported by NSF’s Long-Term Ecological Research (LTER) and National Ecological Observatory Network (NEON), NASA Earth System Science Pathfinder (ESSP) – Earth Ventures (EV) programs, The Smithsonian Institution’s ForestGEO network of plots, and Department of Energy’s (DOE) National Institute for Global Environmental Change (NIGEC). The overarching objectives of the program are to: enhance the ability of students to undertake high-quality interdisciplinary research; build teams of researchers in which students bring different strengths to the table, collaborate on cutting-edge projects, and find their own intellectual “voice”; encourage students to link fundamental and applied issues in their research; and cultivate the next generation of ecological scientists and educators that reflects the diversity of backgrounds and experiences of students in the United States.
 
 
 Problem Statement
 Starting in 2005 the National Science Foundation (NSF), as one of the largest funders of undergraduate research programs, began emphasizing the use of project evaluations to both qualitatively and quantitatively measure the success of REU programs (Research Experiences for Undergraduates (REU) Supplements and Sites: Program Solicitation NSF 05-592, 2005). One objective of this initiative, reaffirmed by the America COMPETES Reauthorization Act of 2010, is to track the success and outcomes of REU participants. Section 514 of this Act requires that “student participants are tracked, for employment and continued matriculation in STEM fields, through receipt of the undergraduate degree and for at least 3 years thereafter”. Due to the long term mission of Harvard Forest and the HF-SRPE, we are actively tracking the success of participants for a minimum of 10 years following their participation in the program.
DOI: 10.18712/nsd-nsd2576-v8
title: Norwegian Citizen Panel Round 11, 2018

description: The Norwegian Citizen Panel is a platform for internet surveys of public opinion in important areas of society and politics in Norway. Participants are randomly recruited from the Norwegian population register, and they are encouraged to participate over time. The panel was fielded for the first time the fall of 2013 and as of 2017 the survey is carried out three times a year. The data set for The Norwegian Citizen Panel Wave 11, 2018 also contains variables from previous waves, the wave number is indicated by the number after "r" in the variable name. The University of Bergen owns and is responsible for the Citizen panel. The company ideas2evidence recruits respondents, produces the survey, and provides documentation of the data. Data is stored and shared by Sikt - Norwegian Agency for Shared Services in Education and Research. The different datasets of the Norwegian Citizen Panel have different ID numbers to prevent the identification of individual participants across rounds. If access to data that follows participants over time (time-series/panel data) is desired, then it must be applied for by contacting DIGSSCORE (uib.no/digsscore / digsscore@uib.no). The same applies to text data and other data that is withheld in these datasets for privacy reasons. The Norwegian Citizen Panel welcomes research proposals for survey content. More information about calls and other updates are available at www.uib.no/en/citizen

The full text for the answer options can be found in the codebook, which is located further down the page.