cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24972171
title: Supplementary Material for: Protective effect of glutathione administration on ovarian function in female rats with cyclophosphamide-induced ovarian damage

description: Objectives:
We investigated the potential of glutathione to protect ovarian function in rats exposed to cyclophosphamide by measuring serum anti-Mullerian hormone levels, follicle counts, and related parameters. 
Design:
Forty-two adult female Sprague-Dawley rats were randomly divided into six groups and treated with various combinations of cyclophosphamide, glutathione, and sodium chloride. On day 21, the rats were anaesthetized, and their ovaries were removed for examination. 
Participants/Materials, Setting, Methods:
Histopathological examination, serum anti-Mullerian hormone (AMH) concentrations, follicle counts, anti-Mullerian hormone-positive staining of follicle percentages were analyzed. Statistical analysis was performed using a one-way analysis of variance and Tukey’s test, with significance set at p&lt;0.05. 
Primary evaluations included serum anti-Mullerian hormone concentrations and ovarian follicle counts. Secondary measures encompassed histopathological examination and percentages of anti-Mullerian hormone-positive staining of follicles.
Results
Significant differences were observed in follicle counts, anti-Mullerian hormone-positive follicle parameters, and serum anti-Mullerian hormone concentrations among the six groups. Group 2 (treated with cyclophosphamide) had the lowest primordial, primary, secondary, and antral follicle counts and the highest atretic count. Group 6, treated with cyclophosphamide and 200 mg/kg glutathione, showed improved follicle counts compared to those in group 2. Reducing the glutathione dose to 100 mg/kg was ineffective. 
Limitations
This was an experimental animal investigation with a comparatively modest sample size. Experimental studies should be conducted to determine the optimal dosage and duration of glutathione therapy. Information gathered from an experimental animal model may not yield precisely similar outcomes in humans; therefore, additional investigations are necessary to examine the impact of glutathione on women experiencing POI. 
Conclusions
The anti-oxidative protective effect of directly administered glutathione was demonstrated for the first time. Low-dose glutathione was ineffective, whereas a high dose yielded significant ovarian protection against cyclophosphamide. Our findings provide valuable insights for supplementing clinical trials on the protective effects of glutathione against ovarian damage.
DOI: 10.6084/m9.figshare.24972171.v1
title: Supplementary Material for: Protective effect of glutathione administration on ovarian function in female rats with cyclophosphamide-induced ovarian damage

description: Objectives:
We investigated the potential of glutathione to protect ovarian function in rats exposed to cyclophosphamide by measuring serum anti-Mullerian hormone levels, follicle counts, and related parameters. 
Design:
Forty-two adult female Sprague-Dawley rats were randomly divided into six groups and treated with various combinations of cyclophosphamide, glutathione, and sodium chloride. On day 21, the rats were anaesthetized, and their ovaries were removed for examination. 
Participants/Materials, Setting, Methods:
Histopathological examination, serum anti-Mullerian hormone (AMH) concentrations, follicle counts, anti-Mullerian hormone-positive staining of follicle percentages were analyzed. Statistical analysis was performed using a one-way analysis of variance and Tukey’s test, with significance set at p&lt;0.05. 
Primary evaluations included serum anti-Mullerian hormone concentrations and ovarian follicle counts. Secondary measures encompassed histopathological examination and percentages of anti-Mullerian hormone-positive staining of follicles.
Results
Significant differences were observed in follicle counts, anti-Mullerian hormone-positive follicle parameters, and serum anti-Mullerian hormone concentrations among the six groups. Group 2 (treated with cyclophosphamide) had the lowest primordial, primary, secondary, and antral follicle counts and the highest atretic count. Group 6, treated with cyclophosphamide and 200 mg/kg glutathione, showed improved follicle counts compared to those in group 2. Reducing the glutathione dose to 100 mg/kg was ineffective. 
Limitations
This was an experimental animal investigation with a comparatively modest sample size. Experimental studies should be conducted to determine the optimal dosage and duration of glutathione therapy. Information gathered from an experimental animal model may not yield precisely similar outcomes in humans; therefore, additional investigations are necessary to examine the impact of glutathione on women experiencing POI. 
Conclusions
The anti-oxidative protective effect of directly administered glutathione was demonstrated for the first time. Low-dose glutathione was ineffective, whereas a high dose yielded significant ovarian protection against cyclophosphamide. Our findings provide valuable insights for supplementing clinical trials on the protective effects of glutathione against ovarian damage.
DOI: 10.6084/m9.figshare.24972132
title: Heat shocks during eggs incubation lead to development, morphological and behavioural differentiation in Arctic charr (<i>Salvelinus alpinus</i>)

description: Temperature variation is affecting fish biodiversity worldwide, causing changes in geographic distribution, phenotypic structure and even species extinction. Incubation is a critical stage for stenothermic species, which are vulnerable to large temperature fluctuations, and its effects on the phenotype at later developmental stages are understudied, despite phenotype is essential for organism ecology and evolution. In this study, we tested the effects heat shocks during the embryonic period on the phenotype of Arctic charr (<i>Salvelinus alpinus</i>). We repeatedly quantified multiple phenotypic traits, including morphology, development and behaviour, over a period of 4 months, from hatching to juvenile stage on individuals having experienced heat shocks (+ 5°C on 24h, seven times) during their embryonic stage or not. We found that heat shocks led to smaller body size at hatching, and a lower sociability. Interestingly, these effects weakened throughout the development of individuals, and even reversed in the case of body size. We also found accelerated growth rate and higher body condition in the presence of heat shocks. Our study provides evidence that heat shocks experienced during incubation can have long-lasting effects on an individual's phenotype. This highlights the importance of the incubation phase for the development of ectothermic organisms, and suggests that temperature fluctuations may have significant ecological and evolutionary implications for Arctic charr. Given the predicted increase in extreme events and unpredictability of temperature fluctuations, it is critical to further investigate their effects on development by examining fluctuations that vary in frequency and intensity.
DOI: 10.6084/m9.figshare.24972132.v1
title: Heat shocks during eggs incubation lead to development, morphological and behavioural differentiation in Arctic charr (<i>Salvelinus alpinus</i>)

description: Temperature variation is affecting fish biodiversity worldwide, causing changes in geographic distribution, phenotypic structure and even species extinction. Incubation is a critical stage for stenothermic species, which are vulnerable to large temperature fluctuations, and its effects on the phenotype at later developmental stages are understudied, despite phenotype is essential for organism ecology and evolution. In this study, we tested the effects heat shocks during the embryonic period on the phenotype of Arctic charr (<i>Salvelinus alpinus</i>). We repeatedly quantified multiple phenotypic traits, including morphology, development and behaviour, over a period of 4 months, from hatching to juvenile stage on individuals having experienced heat shocks (+ 5°C on 24h, seven times) during their embryonic stage or not. We found that heat shocks led to smaller body size at hatching, and a lower sociability. Interestingly, these effects weakened throughout the development of individuals, and even reversed in the case of body size. We also found accelerated growth rate and higher body condition in the presence of heat shocks. Our study provides evidence that heat shocks experienced during incubation can have long-lasting effects on an individual's phenotype. This highlights the importance of the incubation phase for the development of ectothermic organisms, and suggests that temperature fluctuations may have significant ecological and evolutionary implications for Arctic charr. Given the predicted increase in extreme events and unpredictability of temperature fluctuations, it is critical to further investigate their effects on development by examining fluctuations that vary in frequency and intensity.
DOI: 10.34740/kaggle/dsv/7375520
title: AutoXGB
DOI: 10.34740/kaggle/dsv/7375521
title: OnlineFree
DOI: 10.5281/zenodo.10477452
title: Bayesian inference of multimessenger astrophysical data: Joint and coherent inference of gravitational waves and kilonovae

description: We release the set of about 10M equations of state (EOS) used in the paper 

Bayesian inference of multimessenger astrophysical data: Joint and coherent inference of gravitational waves and kilonovae Breschi et al.

The EOS set is generated with a Markov Chain Monte Carlo approach by fixing the crust EOS and assuming i) general relativity; ii) causality at higher densities. Hence, it is agnostic on nuclear physics and not affected by nuclear physics uncertainties. The set includes EOS with and without first order phase transition. Please see

On the maximum mass of neutron stars and GW190814  Godzieba et al. (also arxiv link)

The EOS are four-pieces piecewise polytropes. There are 4 adiabatic indices and three transition densities where the adiabatic index changes. The first index is for the crust EOS and is fixed for all EOSs.            The columns of the original txt files are arranged as follows:                      column 1:  G0 (crust adiabatic index)       \          column 2:  G1                                            |__________ four adiabatic indices          column 3:  G2                                            |          column 4:  G3                                           /           column 5:  log(rho0)    \           column 6:  log(rho1)     |------- log of the three transition densities           column 7:  log(rho2)    /           column 8:  central density of M = 1.4 Msun neutron star           column 9:  radius of M = 1.4 Msun neutron star           column 10: lambda_2 of M = 1.4 Msun neutron star           column 11: central density of maximum mass neutron star           column 12: radius of maximum mass neutron star           column 13: mass of maximum mass neutron star           column 14: maximum sound speed squared divided by the speed of light                      squared (max(c_s^2)/c^2) of the maximum mass neutron star            Each of these columns a dataset of the HDF5.

Please cite the two references above if you use the dataset.
DOI: 10.5281/zenodo.10477451
title: Bayesian inference of multimessenger astrophysical data: Joint and coherent inference of gravitational waves and kilonovae

description: We release the set of about 10M equations of state (EOS) used in the paper 

Bayesian inference of multimessenger astrophysical data: Joint and coherent inference of gravitational waves and kilonovae Breschi et al.

The EOS set is generated with a Markov Chain Monte Carlo approach by fixing the crust EOS and assuming i) general relativity; ii) causality at higher densities. Hence, it is agnostic on nuclear physics and not affected by nuclear physics uncertainties. The set includes EOS with and without first order phase transition. Please see

On the maximum mass of neutron stars and GW190814  Godzieba et al. (also arxiv link)

The EOS are four-pieces piecewise polytropes. There are 4 adiabatic indices and three transition densities where the adiabatic index changes. The first index is for the crust EOS and is fixed for all EOSs.            The columns of the original txt files are arranged as follows:                      column 1:  G0 (crust adiabatic index)       \          column 2:  G1                                            |__________ four adiabatic indices          column 3:  G2                                            |          column 4:  G3                                           /           column 5:  log(rho0)    \           column 6:  log(rho1)     |------- log of the three transition densities           column 7:  log(rho2)    /           column 8:  central density of M = 1.4 Msun neutron star           column 9:  radius of M = 1.4 Msun neutron star           column 10: lambda_2 of M = 1.4 Msun neutron star           column 11: central density of maximum mass neutron star           column 12: radius of maximum mass neutron star           column 13: mass of maximum mass neutron star           column 14: maximum sound speed squared divided by the speed of light                      squared (max(c_s^2)/c^2) of the maximum mass neutron star            Each of these columns a dataset of the HDF5.

Please cite the two references above if you use the dataset.
DOI: 10.5281/zenodo.10477376
title: Global scenarios of anthropogenic mercury emissions in GAINS

description: This dataset contains eight scenarios of future global mercury emissions from the base year 2015 to 2050, generated using the GAINS Global model (https://gains.iiasa.ac.at/gains4/GOD/index.login).

File types and abbreviations, as well as scenario descriptions are found  in "2024_ACP_Brocza-etal_Legend.xlsx" 

Types of files:




em_data_hgpaper_*SCEN*
Hg emissions data by year & region, aggregated


hg_ef_data_hgpaper_*SCEN*
Ranges of emission factors in aggregated regions and sectors


hg_spec_data_hgpaper_*SCEN*
Speciated Hg emissions in aggregated regions and sectors




Level of detail:

Data are aggregated into 15 regions:

Global, Africa, Asia_Pacific (+ sub-regions China, India, Japan, Southeast_Asia), Central_and_South_America (+ Brazil), Eurasia (+ Russia), Europe (+EU27), Middle_East, North_America (+USA).

 

The corresponding manuscript titled "Global scenarios of anthropogenic mercury emissions" has been submitted.
DOI: 10.5281/zenodo.10477377
title: Global scenarios of anthropogenic mercury emissions in GAINS

description: This dataset contains eight scenarios of future global mercury emissions from the base year 2015 to 2050, generated using the GAINS Global model (https://gains.iiasa.ac.at/gains4/GOD/index.login).

File types and abbreviations, as well as scenario descriptions are found  in "2024_ACP_Brocza-etal_Legend.xlsx" 

Types of files:




em_data_hgpaper_*SCEN*
Hg emissions data by year & region, aggregated


hg_ef_data_hgpaper_*SCEN*
Ranges of emission factors in aggregated regions and sectors


hg_spec_data_hgpaper_*SCEN*
Speciated Hg emissions in aggregated regions and sectors




Level of detail:

Data are aggregated into 15 regions:

Global, Africa, Asia_Pacific (+ sub-regions China, India, Japan, Southeast_Asia), Central_and_South_America (+ Brazil), Eurasia (+ Russia), Europe (+EU27), Middle_East, North_America (+USA).

 

The corresponding manuscript titled "Global scenarios of anthropogenic mercury emissions" has been submitted.
DOI: 10.5281/zenodo.10477490
title: Resolving the Polyphyletic
DOI: 10.5281/zenodo.10477491
title: Resolving the Polyphyletic
DOI: 10.6084/m9.figshare.24972204
title: Empty trial.docx

description: Interview data
DOI: 10.6084/m9.figshare.24972204.v1
title: Empty trial.docx

description: Interview data
DOI: 10.4121/c881f6f4-3217-439e-8331-026bce99e9f7.v1
title: Data underlying the research of Kinetic and thermodynamic transition pathways of silica by machine learning: implication for meteorite impacts

description: We construct the potential energy surface of silica under various pressure conditions using machine learning potential and have refined three unique pressure windows, either kinetically or thermodynamically favored, to stabilize seifertite, which reached an agreement with observations in meteorites.
DOI: 10.11588/data/y3kipm
title: Real-time definition of single seed placement sensitivity in low-dose-rate prostate brachytherapy [code and patient data]

description: PURPOSE: In low-dose-rate brachytherapy iodine seeds are implanted based on a treatment plan, generated with respect to different dose constraints. The quality of the dose distribution depends on a precise seed placement, however, it is not clear which seed misplacements have a large impact. MATERIALS AND METHODS: We developed a method using automatic differentiation to calculate gradients of dose parameters with regard to the seeds' positions. Thus, we understand their sensitivity with respect to the seed placement. A statistical analysis is performed on a data set with 35 prostate brachytherapy patients. RESULTS: The most sensitive seeds regarding the dosimetric parameters of both rectum and urethra are close to the corresponding organ. Their gradient directions are mainly orthogonal to their surfaces. However, not all seeds close to the surface are equally sensitive with regard to the dose parameter. The most sensitive seeds regarding the prostate's dose parameters are distributed throughout the prostate and the direction of the gradients are mainly parallel to its surface. A linear regression with respect to different patient parameters shows that dose constraints which are barely fulfilled have large gradients and thus are additionally sensitive to misplacement. CONCLUSION: Automatic differentiation can be used to analyze dose parameter sensitivity with respect to seed placement. Integrating this into treatment planning systems is valuable as it speeds up the planning procedure, making it more robust and less dependent on user experience while showing the operating physician which needle placements require greater accuracy than others.
DOI: 10.5281/zenodo.10477412
title: test data for hycDemux
DOI: 10.5281/zenodo.10477413
title: test data for hycDemux
DOI: 10.6084/m9.figshare.24972219
title: malleable cast iron surface defect dataset(MCISD)

description: malleable cast iron surface defect dataset(MCISD)
DOI: 10.6084/m9.figshare.24935778.v1
title: <b>Extrapulmonary tuberculosis' effects on patients' quality of life and recurrence over a 2-year follow-up period: a prospective cohort study</b>

description: As Supportive Information, Additional File, you can find the minimal dataset from the study "Extrapulmonary tuberculosis' effects on patients' quality of life and recurrence over a 2-year follow-up period: a prospective cohort study." Data set.Ethical clearance was obtained from the Regional Committee for Medical and Health Research Ethics, Western Norway (REK Vest), and the National Bioethics Committee of Pakistan. All study participants signed informed written consent. For participants &lt; 15 years of age, the written consent was signed by the parent or guardian.This study assessed the impact of tuberculous lymphadenitis and pleuritis on patient-reported QoL, the short-term and long-term effects of treatment on QoL, and the recurrence of disease after two years.
DOI: 10.34740/kaggle/ds/4285684
title: 🔥💪Top 1000 YouTube Fitness & Nutrition Channels
DOI: 10.6084/m9.figshare.24972249
title: Supplementary Material for: Management of Patients with Breast Biopsy under Anticoagulation or Antiplatelet Therapy: Results of a Survey of German Experts

description: Introduction
Pre-therapeutic histologic diagnosis through image-guided core needle biopsy (CNB) or vacuum-assisted biopsy (VAB) for suspicious breast findings is a standard procedure. Despite the moderate risk of bleeding, a significant proportion of patients are on temporary or permanent anti-coagulation therapy (ACT) or anti-platelet therapy (APT). Currently, there are no established guidelines for managing biopsies in such patients, leading to varying approaches in clinical practice.

Methods
An online survey was conducted among all members of the breast ultrasound working group at the German Society for Ultrasound in Medicine (DEGUM) and the working group for breast diagnostics at the German Radiology Society (DRG). It included n=51 questions about individual risk perception of biopsy-related bleeding complications and the specific management of biopsies on ACT/APT.

Results 
A total of 332 experts participated, with 51.8% reporting the absence of a standardized management plan for breast biopsies on ACT/APT. Concerning specific ACT/APT medications, the survey revealed discrepancies in risk perception and management: The majority preferred discontinuing medication with directly acting oral anti-coagulants (DOACs; CNB: 66.9%; VAB: 91.1%), phenprocoumon (CNB: 74.9%; VAB: 96.7%), or therapeutic heparin (CNB: 46.1%; VAB: 72.7%). However, there was a lower inclination to discontinue acetylsalicylic acid (ASA; CNB: 15.2%; VAB: 50.3%) or prophylactic heparin (CNB: 11.9%, VAB: 36.3%).

Conclusion 
Breast biopsies for patients on ASA or prophylactic heparin are deemed safe and part of standard clinical practice. However, despite available feasibility studies, conducting breast biopsies on ACT medications such as DOACs or phenprocoumon appears feasible only for a minority of experts.
DOI: 10.6084/m9.figshare.24972477
title: Supplementary Material for: The prenatal hypoxic pathology associated with maternal stress predisposes to dysregulated expression of the chrna7 gene and the subsequent development of nicotine addiction in adult offspring

description: Introduction: Previous studies have shown that fetal hypoxia predisposes individuals to develop addictive disorders in adulthood. However, the specific impact of maternal stress, mediated through glucocorticoids and often coexisting with fetal hypoxia, is not yet fully comprehended. Methods: To delineate the potential effects of these pathological factors, we designed models of prenatal severe hypoxia (PSH) in conjunction with maternal stress and prenatal intrauterine ischemia (PII). We assessed the suitability of these models for our research objectives by measuring HIF1α levels and evaluating the glucocorticoid neuroendocrine system. To ascertain nicotine dependence, we employed the conditioned place aversion test and the startle response test. To identify the key factor implicated in nicotine addiction associated with PSH, we employed techniques such as western blot, immunohistochemistry, and correlational analysis between chrna7 and nr3c1 genes across different brain structures. Results: In adult rats exposed to PSH and PII, we observed increased levels of HIF1α in the hippocampus (HPC). However, the PSH group alone exhibited reduced glucocorticoid receptor (GR) levels and disturbed circadian glucocorticoid rhythms. Additionally, they displayed signs of nicotine addiction in the conditioned place aversion and startle response tests. We also observed elevated levels of phosphorylated DARPP-32 protein in the nucleus accumbens (NAc) indicated compromised glutamatergic efferent signaling. Furthermore, there was reduced expression of α7 nAChR, which modulates glutamate release, in the medial prefrontal cortex (PFC) and HPC. Correlation analysis revealed strong associations between chrna7 and nr3c1 expression in both brain structures.
Conclusion: Perturbations in the glucocorticoid neuroendocrine system and glucocorticoid-dependent gene expression of chrna7 associated with maternal stress response to hypoxia in prenatal period favor the development of nicotine addiction in adulthood.