cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30674231
title: Supplementary Material for: Caregiver Burden in Prion Disease

description: Background: Caregiver burden significantly impacts patient and caregiver outcomes and is an important treatment consideration in dementia. Previous research has demonstrated that like behavioral variant frontotemporal dementia, prion disease has higher caregiver burden than other forms of dementia; however, limited prospective research has investigated this specifically. Here we aim to describe caregiver wellbeing and burden in prion disease and determine whether demographic features, support group attendance, or features of the disease process predicted higher caregiver burden. 
Methods: 30 patients with prion disease and their caregivers were assessed longitudinally through the Teleneurology Assessment Program for Creutzfeldt-Jakob Disease. Caregivers were administered assessment instruments including the Neuropsychiatric Inventory Questionnaire (NPI-Q), MRC Prion Disease Rating Scale, and Outcome Evaluation of the National Family Caregiver Support Program. We performed descriptive and inferential statistics to examine the progression of caregiver burden and identify features that impacted caregiver burden severity. 
Results: 30 caregiver-patient dyads were followed longitudinally. Prion disease duration averaged 7.88 months. Mean initial NPI-Q distress score was 15. Qualitatively, distress increased until peaking on average half-way through disease duration, then declined. Higher burden (4-item Zarit Burden Interview) was associated with younger age at disease onset. Burden was not predicted by disease type, duration, caregiver demographics, MRC Prion Rating Scale scores, NPI-Q, or support group attendance
Conclusion: These findings confirm significant caregiver distress in prion disease and help to describe the course of caregiver burden throughout the disease. Statistical analyses were limited by small sample size and phenotypic heterogeneity and future research would benefit from larger samples.
DOI: 10.6084/m9.figshare.30674231.v1
title: Supplementary Material for: Caregiver Burden in Prion Disease

description: Background: Caregiver burden significantly impacts patient and caregiver outcomes and is an important treatment consideration in dementia. Previous research has demonstrated that like behavioral variant frontotemporal dementia, prion disease has higher caregiver burden than other forms of dementia; however, limited prospective research has investigated this specifically. Here we aim to describe caregiver wellbeing and burden in prion disease and determine whether demographic features, support group attendance, or features of the disease process predicted higher caregiver burden. 
Methods: 30 patients with prion disease and their caregivers were assessed longitudinally through the Teleneurology Assessment Program for Creutzfeldt-Jakob Disease. Caregivers were administered assessment instruments including the Neuropsychiatric Inventory Questionnaire (NPI-Q), MRC Prion Disease Rating Scale, and Outcome Evaluation of the National Family Caregiver Support Program. We performed descriptive and inferential statistics to examine the progression of caregiver burden and identify features that impacted caregiver burden severity. 
Results: 30 caregiver-patient dyads were followed longitudinally. Prion disease duration averaged 7.88 months. Mean initial NPI-Q distress score was 15. Qualitatively, distress increased until peaking on average half-way through disease duration, then declined. Higher burden (4-item Zarit Burden Interview) was associated with younger age at disease onset. Burden was not predicted by disease type, duration, caregiver demographics, MRC Prion Rating Scale scores, NPI-Q, or support group attendance
Conclusion: These findings confirm significant caregiver distress in prion disease and help to describe the course of caregiver burden throughout the disease. Statistical analyses were limited by small sample size and phenotypic heterogeneity and future research would benefit from larger samples.
DOI: 10.6084/m9.figshare.30674237
title: Supplementary Material for: Conversion resection or direct resection for patients with intermediate-stage hepatocellular carcinoma: a multicentre study

description: Introduction: The majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an intermediate stage, and current treatment options are associated with unfavorable overall prognosis. This study aimed to evaluate the efficacy of conversion therapy before resection compared with direct resection or comprehensive therapy alone in patients with intermediate-stage HCC, with a focus on pathological responses and long-term outcomes.
Methods: In this multicentre study, 248 patients diagnosed with intermediate-stage HCC between January 2020 and December 2023 were enrolled. Of these, 56 patients received preoperative conversion therapy followed by resection (conversion resection group), 162 underwent direct resection (direct resection group), and 30 received comprehensive therapy alone and did not undergo surgical resection (comprehensive therapy group). Propensity score matching was performed to balance the baseline characteristics, and pathological responses were systematically evaluated.
Results: Among conversion resection group, 13 patients (23.2%) achieved a pathological complete response, and 29 (51.8%) achieved a major pathological response. The conversion resection group exhibited significantly lower microvascular invasion rates (17.9% vs. 58.6%, p&lt;0.001) and higher tumour differentiation grades (p&lt;0.001). The median recurrence-free survival (RFS) was markedly improved in the conversion resection group (not reached vs. 12.3 months, p&lt;0.001), with 3-year overall survival (OS) rates of 94.7% vs. 77.6% vs. 43.9% being observed in the conversion resection group, direct resection group and comprehensive therapy group, respectively (p&lt;0.001). Multivariate analysis identified conversion therapy as an independent prognostic factor for both RFS (HR: 0.241, p&lt;0.001) and OS (HR: 0.179, p=0.006).
Conclusions: Preoperative conversion therapy could significantly improve pathological responses and long-term survival outcomes in intermediate-stage HCC patients.
DOI: 10.6084/m9.figshare.30674237.v1
title: Supplementary Material for: Conversion resection or direct resection for patients with intermediate-stage hepatocellular carcinoma: a multicentre study

description: Introduction: The majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an intermediate stage, and current treatment options are associated with unfavorable overall prognosis. This study aimed to evaluate the efficacy of conversion therapy before resection compared with direct resection or comprehensive therapy alone in patients with intermediate-stage HCC, with a focus on pathological responses and long-term outcomes.
Methods: In this multicentre study, 248 patients diagnosed with intermediate-stage HCC between January 2020 and December 2023 were enrolled. Of these, 56 patients received preoperative conversion therapy followed by resection (conversion resection group), 162 underwent direct resection (direct resection group), and 30 received comprehensive therapy alone and did not undergo surgical resection (comprehensive therapy group). Propensity score matching was performed to balance the baseline characteristics, and pathological responses were systematically evaluated.
Results: Among conversion resection group, 13 patients (23.2%) achieved a pathological complete response, and 29 (51.8%) achieved a major pathological response. The conversion resection group exhibited significantly lower microvascular invasion rates (17.9% vs. 58.6%, p&lt;0.001) and higher tumour differentiation grades (p&lt;0.001). The median recurrence-free survival (RFS) was markedly improved in the conversion resection group (not reached vs. 12.3 months, p&lt;0.001), with 3-year overall survival (OS) rates of 94.7% vs. 77.6% vs. 43.9% being observed in the conversion resection group, direct resection group and comprehensive therapy group, respectively (p&lt;0.001). Multivariate analysis identified conversion therapy as an independent prognostic factor for both RFS (HR: 0.241, p&lt;0.001) and OS (HR: 0.179, p=0.006).
Conclusions: Preoperative conversion therapy could significantly improve pathological responses and long-term survival outcomes in intermediate-stage HCC patients.
DOI: 10.34740/kaggle/dsv/13813553
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.6084/m9.figshare.30657758
title: <b>Unveiling Cytochrome P450 Enzymes that Catalyze Steroid Side-Chain Clea</b><b>vage in Bacteria-MD simulations</b>

description: All data associated with the MD simulations
DOI: 10.6084/m9.figshare.30657758.v3
title: <b>Unveiling Cytochrome P450 Enzymes that Catalyze Steroid Side-Chain Clea</b><b>vage in Bacteria-MD simulations</b>

description: All data associated with the MD simulations
DOI: 10.6084/m9.figshare.30657758.v2
title: <b>Unveiling Cytochrome P450 Enzymes that Catalyze Steroid Side-Chain Cleavage in Bacteria</b>

description: The input files for energy minimization and equilibration and the files for production runs
DOI: 10.15468/dl.8wgunq
title: Occurrence Download

description: A dataset containing 1216 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Occurrence evidence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Litchi chinensis"
 ]
}

 The dataset includes 1216 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001800-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29755613
title: <b>The Impact of Internet Use in the Digital Era on Public Political Trust in China—An Empirical Study Based on CGSS</b><b> </b><b>2021 Data</b>

description: The dataset used for “<b>The Impact of Internet Use in the Digital Era on Public Political Trust in China—An Empirical Study Based on CGSS</b><b> </b><b>2021 Data</b>” requires opening with SPSS software.
DOI: 10.6084/m9.figshare.29755613.v2
title: <b>The Impact of Internet Use in the Digital Era on Public Political Trust in China—An Empirical Study Based on CGSS</b><b> </b><b>2021 Data</b>

description: The dataset used for “<b>The Impact of Internet Use in the Digital Era on Public Political Trust in China—An Empirical Study Based on CGSS</b><b> </b><b>2021 Data</b>” requires opening with SPSS software.
DOI: 10.6084/m9.figshare.29755613.v1
title: PONE-D-25-01950.sav

description: PONE-D-25-01950 paper dataset
DOI: 10.15468/dl.ws5f7q
title: Occurrence Download

description: A dataset containing 484 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "TaxonKey is Phylloscopus tytleri",
 "Year 2024-2025"
 ]
}

 The dataset includes 484 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001801-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21227/xdvc-1038
title: "Andro-AutoPsy: Similarity-Based Android Malware and Benign Application Dataset"

description: "The Andro-AutoPsy dataset consists of Android malware and benign application samples collected to support research on similarity-based malware detection. Each application is analyzed using behavior-centric and creator-centric features, including certificate serial numbers, malicious API usage, permission likelihood ratios, system command execution, intent manipulation, and file integrity anomalies.The dataset was created for the Andro-AutoPsy system, which classifies applications by measuring the similarity of extracted behavioral footprints and identifying malware creator signatures. This approach enables not only malware detection but also grouping of malicious applications into behaviorally similar subfamilies. The system demonstrates strong applicability to zero-day malware detection and provides an alternative to traditional signature-based detection."
DOI: 10.15151/esrf-es-2290369132
title: Self-assembly of oppositely charged surfactants

description: Spontaneous self-assembly of cationic and anionic surfactants in the micromolar concentration range will be probed.
DOI: 10.15151/esrf-es-2232203021
title: Macromolecular crystallography at the Philipps University Marburg (MarBAG)

description: The MarBAG, based at Philipps-University Marburg and the Max-Planck-Institute for Terrestrial Microbiology in Marburg, Germany, employs X-ray crystallography to elucidate the fundamental mechanisms underlying the synthesis, assembly, and function of macromolecular machines and cellular structures. This research encompasses critical biological processes, including CO2 fixation pathways, flagellar biosynthesis, CRISPR-Cas systems, and phage-bacteria interactions. Additionally, our investigations extend to plant-pathogen interactions and the role of nucleotide-derived signaling molecules in cellular stress physiology and organization of bacteria and higher organisms.
To enhance our structural characterization of macromolecular complexes that are challenging to crystallize, we have recently installed a 200 keV cryo-electron microscope at UMR. This advanced instrumentation enables routine screening and quality assessment of samples for cryoelectron microscopy.
DOI: 10.15151/esrf-es-2232212192
title: Development of novel small molecules to target cellular pathways

description: Small molecules represent powerful tools to dissect physiological and pathological states of signaling pathways, yet require characterization through X-ray crystallography. This proposal encompasses the investigation of new classes of small molecules that target difficult proteins and non-typical binding sites. This includes the development of supramolecular compounds or cyclic peptides to address “non-druggable" proteins. The main collaborative research fields are tackling Ras protein signaling with structure-guided ligand design, developing inhibitors of the Ras-binding protein PDEd, screening of a novel sp3-enriched fragment library or targeting genetic regulators. Cellular signaling will also be addressed through the structural analysis of deubiquitinating enzymes or regulators of the kinetochore. Finally, we plan to crystallize membrane proteins including GPCRs in order to understand their biological function, characterize their ligand specificity and develop novel regulators.
DOI: 10.15151/esrf-es-2233785992
title: Munich Crystallography BAG

description: The diverse groups of the Munich Crystallography BAG study a far range of subjects, reaching from structural aspects of fundamental cellular processes - such as RNA processing, protein folding and degradation, DNA repair, chromatin remodelling, enzymes - to the design of foldamers. The research groups are located at the LMU and TUM universities in Munich, at the Max-Planck-Institute of Biochemistry, Martinsried, and the Helmholtz Center, Neuherberg. Out-groups are located at the universities in Darmstadt and Ulm, Germany. The research groups use X-ray crystallography, single-particle cryo-EM, cryo-ET, SAXS, NMR and HDX and XL-MS mass-spectrometry for structural studies.
DOI: 10.15151/esrf-es-2283072140
title: FePS3 bulk Polarimetry measurements

description: FePS3 (vdW antiferromagnet) complementary RIXS measurements
DOI: 10.15151/esrf-es-2280421631
title: HiP-CT of human organs and head

description: Continuation of the experiment for scanning human heads in 70% ethanol using HiP-CT. Head scanned during IH-MD-69 and IH-MD-72 has been remounted according to a new protocol. The aim is to verify whether the improved preparation process has allowed to place the head in a good position for scanning, with sensitive areas protected. If time will allow, human and animal organs in ethanol and in 4% formalin, mounted in agar will be scanned as well
DOI: 10.17169/refubium-39163
title: Replication Data for: The Loongana (CL) group of carbonaceous chondrites

description: A coordinated study of the petrology, mineral chemistry, and bulk chemical and isotopic composition of the five ungrouped carbonaceous chondrites Coolidge, Loongana 001, Los Vientos (LoV) 051, Northwest Africa (NWA) 033, and NWA 13400 reveals that these meteorites have a similar set of properties that distinguishes them from the other carbonaceous chondrite groups and allows definition of the new Loongana (CL) group of carbonaceous chondrites.
DOI: 10.15151/esrf-es-2277876527
title: Study of the filamentation of ISN1 from C. glabrata in the presence of its substrate IMP.

description: Candidemia, a bloodstream infection caused by Candida yeasts, represents a serious public health concern due to rising antifungal resistance. Candida glabrata, in particular, is known for its high resistance to conventional antifungal drugs, making the discovery of new therapeutic strategies an urgent priority.

To achieve this, the protein Isn1, a pivotal enzyme hydrolyzing both IMP (purine pathway) and possibly NMN (NAD pathway) is studied by X-ray crystallography, cryo-EM, and enzymology to uncover how ISN1 functions at the molecular level and to assess its potential as a novel antifungal target. Some preliminary data collected on the Glacios at IBS on the filamentous form of Isn1 gave a 3.17 A resolution. A data collection on a 300 kV microscope is now requested to reach a higher resolution that will allow a more complete description of the ligand biding as well as filament formation.
DOI: 10.57770/jgkwdg
title: Enhancing Cisplatin Efficacy in Hepatocellular Carcinoma with Selenocystine: The Suppression of DNA Repair and Inhibition of Proliferation in Hepatoma Cells

description: Cisplatin (cDDP) is a crucial chemotherapy drug for treating various cancers, including hepatocellular carcinoma (HCC). However, its effectiveness is often hindered by side effects and drug resistance. Selenocystine (SeC) demonstrates potential as an anticancer agent, particularly by inhibiting DNA repair mechanisms. This study explored the synergistic potential of SeC combined with cDDP for treating HCC. Our results show that SeC pretreatment followed by cDDP significantly suppresses HCC cell proliferation more effectively than either treatment alone, with minimal toxicity to normal liver cells. The combination induces significant DNA damage by inhibiting homologous recombination (HR) and non-homologous end joining (NHEJ) pathways. Xenograft experiments confirmed that the combined therapy strongly inhibits tumor growth. SeC boost the effectiveness of cDDP by amplifying DNA damage and inhibiting DNA repair, presenting a promising approach to enhancing liver cancer treatment.
DOI: 10.15151/esrf-es-2248510470
title: Activation and degredation of Co-based nitrate reduction electrocatalyst under relevant industrial conditions probed with XRD and XAS

description: The electrochemical reduction of nitrate into ammonia (NO3RR) is a promising approach to valorizing nitrogen waste from industrial point sources. Efficient catalysts based on metal-oxides/hydroxides, e.g. CoxOxHz, often undergo severe structural and compositional alterations during NO3RR which can even become superimposed by parasitic hydrogen evolution reaction (HER). Here, we apply a tandem X-ray absorption spectroscopy (XAS) and X-ray diffraction (XRD) technique under operando conditions to probe for the first-time catalyst activation and possible degradation phenomena under realistic industrial conditions in flow-cell configuration using nitrate concentrations beyond 1 M and electrolytes with a pH 4.5. We will demonstrated to which extent the local increase of the surface pH at ampere level NO3RR rates may kinetically stabilize cobalt oxides/hydroxides as active catalyst species even at mildly acid pH in the ”bulk” electrolyte solution.
DOI: 10.15151/esrf-es-2248516982
title: XRD Investigation of Novel Argon Filled-Ices to Extreme Pressures and Temperatures

description: Gas-filled ices are crystalline compounds of paramount importance to planetary science and potential energy storage applications, but the general understanding of their nature is challenged by a glaring inconsistency. Hydrogen and methane filled ices have been shown to be stable up to pressures of at least 90 GPa and 150 GPa, respectively, while homologous noble gas filled-ices were so far found to decompose just above a few GPa. On the othe hand, our recent Raman spectroscopy measurements show that argon filled-ice, when compressed fast enough through a narrow instability range: 5-10 GPa, remains well stable up to at least 40 GPa and also exhibits a phase transition from the previously known filled-ice phase ArH-IV to a new and unknown filled-ice phase. Here we propose to investigate this phase transition, the new structure and the related compression curves using powder XRD, to pressures of 50-80 GPa. This study will likely reconcile the inconsistency between filled ices.
DOI: 10.15151/esrf-es-2248519405
title: Selected D2O and H2O ices and phase transitions among them with Hirshfeld Atom Refinement

description: Studying ices is crucial for several scientific reasons, especially in fields like planetary science, astrophysics, and environmental science. Among the 23 structures of solid ices deposited in ICSD, in 7 the positions of H/D atoms are not determined, and in 10 only the isotropic ADPs for H/D atoms were refined. With HAR we can get H/D atom positions and ADPs as we have already proved in the case of ice VI and VII. We can also improve the neutron models of ices(as we have done for ice VII). We aim to apply HAR in order to: (a) establish structures of the following polymorphic forms of the D2O and H2O ices: II, III, V and VIII, Ih (hexagonal) and Ic(cubic), (b) improve geometry an establish anisotropic (maybe even anharmonic) ADP parameters for H/D atoms in these structures, (c) study phase transitions among different ices to explain their complex nature and correlate structural phenomena with thermodynamic data.
DOI: 10.15151/esrf-es-2248520987
title: Operando HERFD XANES and Kβ XES study on Co based alloy nanoparticles for Oxygen Evolution Reaction (OER) probing dynamic spin state and ele

description: Enhancing alkaline water splitting efficiency is critical for the widespread adoption of anion exchange membrane (AEM) electrolyzers. The oxygen evolution reaction (OER) is the key limiting step, and gaining a deeper understanding of transition metal-based catalysts under operating conditions is essential for design of improved electrocatalysts for OER. Our previous operando L-edge X-ray absorption spectroscopy (XAS) study on cobalt nanoparticles has revealed reversible oxidation and low-spin species formation at 1.65 V vs. RHE. However, L-edge XAS alone is challenging to fully distinguish between oxidation state changes, spin state transitions, and coordination environment evolution. To address this gap, we propose an operando study using high-energy-resolution fluorescence-detected X-ray absorption near-edge structure (HERFD-XANES) and X-ray emission spectroscopy (XES). These techniques will provide critical insights into the dynamic electronic structure of Co alloy catalysts.