cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25592/uhhfdm.17305
title: Research-based learning in writing studies

description: The courses discussed cover topics of writing studies and are part of the extension curriculum “Writing Mentoring: Developing, Teaching and Researching Academic Writing”, which is offered by the Center of Teaching and Learning and the Department of German Philology at the University of Vienna. It can be attended by students of all subjects.
DOI: 10.25592/uhhfdm.17110
title: Forschendes Lernen in der Schreibwissenschaft

description: Die hier vorgestellte Veranstaltung ist im Bereich der Schreibforschung angesiedelt und wird vom Center of Teaching and Learning der Universität Wien in Kooperation mit dem Institut für Deutsche Philologie  angeboten. Es ist ein extracurriculares Angebot und kann von Studierenden aller Fachrichtungen besucht werden.
DOI: 10.25592/uhhfdm.17304
title: Research-based learning in writing studies

description: The courses discussed cover topics of writing studies and are part of the extension curriculum “Writing Mentoring: Developing, Teaching and Researching Academic Writing”, which is offered by the Center of Teaching and Learning and the Department of German Philology at the University of Vienna. It can be attended by students of all subjects.
DOI: 10.25592/uhhfdm.17109
title: Forschendes Lernen in der Schreibwissenschaft

description: Die hier vorgestellte Veranstaltung ist im Bereich der Schreibforschung angesiedelt und wird vom Center of Teaching and Learning der Universität Wien in Kooperation mit dem Institut für Deutsche Philologie  angeboten. Es ist ein extracurriculares Angebot und kann von Studierenden aller Fachrichtungen besucht werden.
DOI: 10.5281/zenodo.14443056
title: Performance Analysis of 5G User Plane Positioning via LCS-UPP

description: This contribution addresses 5G user plane positioning by providing an implementation and a performance analysis of selected procedures of the Location Services User Plane Protocol (LCS-UPP) according to Release 18 of the 3GPP TS 24.572. More precisely, the following pieces of information are included:



time measurements of LCS-UPP transport time depending on different TLS 1.3 implementation approaches and potential LPP payload size,

reference to a corresponding GitLab repository that contains the implementation files.


Note: The contents are part of the following publication: "User Plane Positioning in 5G Networks: A Design Space Study for Implementation". As mentioned below, the corresponding paper will be presented at the 21st International IEEE Conference on Factory Communication Systems (WFCS 2025, June 10-13 2025).
DOI: 10.6084/m9.figshare.29040231
title: Optimised formulation and characterisation of liposomes for enhanced stability and antiproliferative efficacy of <i>Orthosiphon aristatus</i> var. <i>aristatus</i> extract in lung cancer treatment

description: This study aimed to characterise and evaluate the antiproliferative potency of a standardised 50% ethanol extract of <i>Orthosiphon aristatus</i> var. <i>aristatus</i> leaves against human lung cancer cells <i>in vitro</i>. A liposomal drug delivery system was developed to enhance bioavailability and efficacy. Three formulations were designed with different extract-to-phospholipid ratios, phospholipid, and cholesterol content. NP2, formulated with a 1:1 extract-to-phosphatidylcholine ratio and 20% cholesterol, demonstrated optimal stability and efficacy. Liposomes were quantitatively and qualitatively characterised using light microscopy, TEM, SEM, zeta sizer, and zeta potential analysis. NP2 demonstrated better bioactive compounds release properties and better stability than the extract. The extract and liposomes inhibited the proliferation of human lung adenocarcinoma (A549) and normal endothelial cells (EA.hy926). The findings indicate that the extract possesses potent anti-lung cancer activity, with the NP2 liposomal formulation enhancing its therapeutic potential.
DOI: 10.6084/m9.figshare.29040231.v1
title: Optimised formulation and characterisation of liposomes for enhanced stability and antiproliferative efficacy of <i>Orthosiphon aristatus</i> var. <i>aristatus</i> extract in lung cancer treatment

description: This study aimed to characterise and evaluate the antiproliferative potency of a standardised 50% ethanol extract of <i>Orthosiphon aristatus</i> var. <i>aristatus</i> leaves against human lung cancer cells <i>in vitro</i>. A liposomal drug delivery system was developed to enhance bioavailability and efficacy. Three formulations were designed with different extract-to-phospholipid ratios, phospholipid, and cholesterol content. NP2, formulated with a 1:1 extract-to-phosphatidylcholine ratio and 20% cholesterol, demonstrated optimal stability and efficacy. Liposomes were quantitatively and qualitatively characterised using light microscopy, TEM, SEM, zeta sizer, and zeta potential analysis. NP2 demonstrated better bioactive compounds release properties and better stability than the extract. The extract and liposomes inhibited the proliferation of human lung adenocarcinoma (A549) and normal endothelial cells (EA.hy926). The findings indicate that the extract possesses potent anti-lung cancer activity, with the NP2 liposomal formulation enhancing its therapeutic potential.
DOI: 10.21233/6te4-f371
title: North Lake pollen surface sample dataset

description: Raw data for the North Lake pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.29040246
title: Penicinoid A, an undescribed sesterterpenoid with cytotoxic activity from <i>Penicillium herquei</i>

description: Penicinoid A (<b>1</b>), a previously undescribed sesterterpenoid, and ten known compounds, variculanol (<b>2</b>), citreoanthrasteroid A (<b>3</b>), ergosta-7,22<i>E</i>-diene-2<i>β</i>,3<i>α</i>,9<i>α</i>-triol (<b>4</b>), (22<i>E</i>,24<i>R</i>)-23-methylergosta-7,22-diene-3<i>β</i>,5<i>α</i>,6<i>β</i>,9<i>α</i>-tetrol (<b>5</b>), 9,11-dehydroergosterol peroxide (<b>6</b>), (22<i>E</i>,24<i>R</i>)-3<i>β</i>,5<i>α</i>,9<i>α</i>-trihydroxy-ergosta-7,22-dien-6-one (<b>7</b>), gymnasterone C (<b>8</b>), cyathisterol (<b>9</b>), demethylincisterol A3 (<b>10</b>), volemolide (<b>11</b>), were obtained from <i>Aconitum carmichaelii</i> endophytic fungus <i>Penicillium herquei</i>. Their structures were characterised by NMR, HRESIMS, ECD calculations and comparison with the reported literatures. All isolates were screened on their cytotoxicity against A549, Hepg2, HeLa, and HCT116 cells. Compounds <b>1</b>–<b>11</b> exhibited significant to weak cytotoxic effects (IC<sub>50</sub> values: 1.5 ± 0.1–37.3 ± 3.0 <i>μ</i>M). Additionally, their inhibitory activity on NO production in LPS stimulated RAW 264.7 macrophages were evaluated. Compounds <b>1</b>–<b>11</b> showed moderate to weak inhibitory activity (IC<sub>50</sub> values: 10.9 ± 1.0–35.1 ± 3.1 <i>μ</i>M). This is the first time that sesterterpenoids were found from the secondary metabolites of <i>P. herquei</i>.
DOI: 10.6084/m9.figshare.29040246.v1
title: Penicinoid A, an undescribed sesterterpenoid with cytotoxic activity from <i>Penicillium herquei</i>

description: Penicinoid A (<b>1</b>), a previously undescribed sesterterpenoid, and ten known compounds, variculanol (<b>2</b>), citreoanthrasteroid A (<b>3</b>), ergosta-7,22<i>E</i>-diene-2<i>β</i>,3<i>α</i>,9<i>α</i>-triol (<b>4</b>), (22<i>E</i>,24<i>R</i>)-23-methylergosta-7,22-diene-3<i>β</i>,5<i>α</i>,6<i>β</i>,9<i>α</i>-tetrol (<b>5</b>), 9,11-dehydroergosterol peroxide (<b>6</b>), (22<i>E</i>,24<i>R</i>)-3<i>β</i>,5<i>α</i>,9<i>α</i>-trihydroxy-ergosta-7,22-dien-6-one (<b>7</b>), gymnasterone C (<b>8</b>), cyathisterol (<b>9</b>), demethylincisterol A3 (<b>10</b>), volemolide (<b>11</b>), were obtained from <i>Aconitum carmichaelii</i> endophytic fungus <i>Penicillium herquei</i>. Their structures were characterised by NMR, HRESIMS, ECD calculations and comparison with the reported literatures. All isolates were screened on their cytotoxicity against A549, Hepg2, HeLa, and HCT116 cells. Compounds <b>1</b>–<b>11</b> exhibited significant to weak cytotoxic effects (IC<sub>50</sub> values: 1.5 ± 0.1–37.3 ± 3.0 <i>μ</i>M). Additionally, their inhibitory activity on NO production in LPS stimulated RAW 264.7 macrophages were evaluated. Compounds <b>1</b>–<b>11</b> showed moderate to weak inhibitory activity (IC<sub>50</sub> values: 10.9 ± 1.0–35.1 ± 3.1 <i>μ</i>M). This is the first time that sesterterpenoids were found from the secondary metabolites of <i>P. herquei</i>.
DOI: 10.21233/41bh-tn41
title: LDDsite3310 ostracode surface sample dataset

description: Raw data for the LDDsite3310 ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.7910/dvn/6ixxym
title: Supernova Event Dataset

description: Critical event dataset
DOI: 10.6084/m9.figshare.29040252
title: Loading esculin can improve the morphology and antibacterial properties of chitosan/whey protein isolate composite film

description: In this study, chitosan (CTS), whey protein isolate (WPI) and glycerol were used as biodegradable film-forming matrices to prepare composite films by solution blending. Esculin (ES) as antibacterial active compound, was added during the film modification process. CTS, CTS/WPI (C/W) and CTS/WPI/ES (C/W/ES) films were compared in terms of structure, physical properties and functions. Due to the effect of ES, C/W/ES film has good mechanical properties, barrier properties, and biodegradability. Compared with C/W film, the tensile strength, elongation at break, antioxidant activity, and biodegradability of C/W/ES film increased by 36.4%, 9.6%, 37.0%, and 33.65%, respectively. Its antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was significantly enhanced. The cherry tomato preservation test showed that C/W/ES film had a good effect on weight loss rate and decay rate of the fruits. In summary, loading ES can improve the morphology and antibacterial properties of the biodegradable composite film.
DOI: 10.6084/m9.figshare.29040252.v1
title: Loading esculin can improve the morphology and antibacterial properties of chitosan/whey protein isolate composite film

description: In this study, chitosan (CTS), whey protein isolate (WPI) and glycerol were used as biodegradable film-forming matrices to prepare composite films by solution blending. Esculin (ES) as antibacterial active compound, was added during the film modification process. CTS, CTS/WPI (C/W) and CTS/WPI/ES (C/W/ES) films were compared in terms of structure, physical properties and functions. Due to the effect of ES, C/W/ES film has good mechanical properties, barrier properties, and biodegradability. Compared with C/W film, the tensile strength, elongation at break, antioxidant activity, and biodegradability of C/W/ES film increased by 36.4%, 9.6%, 37.0%, and 33.65%, respectively. Its antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was significantly enhanced. The cherry tomato preservation test showed that C/W/ES film had a good effect on weight loss rate and decay rate of the fruits. In summary, loading ES can improve the morphology and antibacterial properties of the biodegradable composite film.
DOI: 10.6084/m9.figshare.29040258
title: NMR and mass spectral studies of ‘Abaliose’ – a novel hexasaccharide isolated from <i>Bubalus bubalis</i> milk

description: Milk oligosaccharides confer unique health benefits to the neonates. Recent studies show that these milk oligosaccharides (MO) show potent medicinal activities such as anti-tumour, immunostimulant, anti-complimentary, anti-cancerous, anti-inflammatory, anti-diabetic and active against virus. Buffalo milk oligosaccharide induces significant stimulation of antibody, delayed type hypersensitivity and non-specific immune response. Keeping the biological activities of buffalo MOs in mind, it was processed by the method developed by Deepak et al. Thereafter its purification involving chromatographic techniques, resulted in isolation of a novel hexasaccharide ‘Abaliose’. Three-dimensional structure of this oligosaccharide was elucidated by HSQC, TOCSY, COSY and HMBC NMR experiments and mass spectrometric data confirming it to be a Novel hexasaccharide made up of Glc, Gal, GlcNHAc and GalNHAc linked together by β-(1→4), β-(1→3) and β-(1→2) glycosidic linkages (Figure 1).
DOI: 10.6084/m9.figshare.29040258.v1
title: NMR and mass spectral studies of ‘Abaliose’ – a novel hexasaccharide isolated from <i>Bubalus bubalis</i> milk

description: Milk oligosaccharides confer unique health benefits to the neonates. Recent studies show that these milk oligosaccharides (MO) show potent medicinal activities such as anti-tumour, immunostimulant, anti-complimentary, anti-cancerous, anti-inflammatory, anti-diabetic and active against virus. Buffalo milk oligosaccharide induces significant stimulation of antibody, delayed type hypersensitivity and non-specific immune response. Keeping the biological activities of buffalo MOs in mind, it was processed by the method developed by Deepak et al. Thereafter its purification involving chromatographic techniques, resulted in isolation of a novel hexasaccharide ‘Abaliose’. Three-dimensional structure of this oligosaccharide was elucidated by HSQC, TOCSY, COSY and HMBC NMR experiments and mass spectrometric data confirming it to be a Novel hexasaccharide made up of Glc, Gal, GlcNHAc and GalNHAc linked together by β-(1→4), β-(1→3) and β-(1→2) glycosidic linkages (Figure 1).
DOI: 10.6084/m9.figshare.29040270
title: Quorum quenching mediated virulence factor impairment by <i>Pandanus tectorius</i> leaf extract against <i>Chromobacterium violaceum</i>

description: This study investigated the anti-quorum sensing ability of <i>Pandanus tectorius</i> (PT) leaf extract in suppressing virulence factors including biofilm formation in <i>Chromobacterium violaceum</i> under <i>in vitro</i> conditions. The extract significantly inhibited the biosynthesis of violacein, acyl homoserine lactone, chitinase, exopolysaccharides, haemolysin, and outer membrane vesicles at sub-MIC concentrations of 1.5, 1, and 0.5 mg/ml. Biofilm formation was reduced by 81.46% at a concentration of 1.5 mg/ml. PT leaf extract also downregulated the quorum sensing-associated genes, including <i>cviI</i>, <i>cviR</i>, and <i>vioA</i> of <i>C. violaceum</i>. GC-MS analysis identified 15 major bioactive compounds, which were docked with the cviR master regulator protein. Among those, stigmasterol demonstrated efficient binding at the active site of cviR, with a binding energy of −8.5 kcal/mol. Toxicity assays confirmed the non-toxic nature of the PT extract, highlighting its potential as a safe anti-quorum sensing agent.
DOI: 10.6084/m9.figshare.29040270.v1
title: Quorum quenching mediated virulence factor impairment by <i>Pandanus tectorius</i> leaf extract against <i>Chromobacterium violaceum</i>

description: This study investigated the anti-quorum sensing ability of <i>Pandanus tectorius</i> (PT) leaf extract in suppressing virulence factors including biofilm formation in <i>Chromobacterium violaceum</i> under <i>in vitro</i> conditions. The extract significantly inhibited the biosynthesis of violacein, acyl homoserine lactone, chitinase, exopolysaccharides, haemolysin, and outer membrane vesicles at sub-MIC concentrations of 1.5, 1, and 0.5 mg/ml. Biofilm formation was reduced by 81.46% at a concentration of 1.5 mg/ml. PT leaf extract also downregulated the quorum sensing-associated genes, including <i>cviI</i>, <i>cviR</i>, and <i>vioA</i> of <i>C. violaceum</i>. GC-MS analysis identified 15 major bioactive compounds, which were docked with the cviR master regulator protein. Among those, stigmasterol demonstrated efficient binding at the active site of cviR, with a binding energy of −8.5 kcal/mol. Toxicity assays confirmed the non-toxic nature of the PT extract, highlighting its potential as a safe anti-quorum sensing agent.
DOI: 10.21233/zn87-ng50
title: SOK-K12 pollen surface sample dataset

description: Raw data for the SOK-K12 pollen surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.29040273
title: Rutin attenuates iron overload induced-ferroptosis in rats’ heart tissue

description: Rutin is a natural flavonoid with antioxidant and iron chelating properties. Therefore, this study aimed to investigate the ameliorative effects of rutin against iron-overload and ionising radiation induced (IR)-ferroptosis in rats’ heart tissue. Rats were divided into nine groups; control, Rutin, IR, Fe, Fe + IR, Fe + Rutin, IR+Rutin, Fe + IR+Rutin and Fe + IR+Deferasirox. Serum iron profiles total iron, TIBC, ferritin, transferrin, and hepicidin were determined. Moreover, MDA, GSH, and NO levels and GPx, and SOD activities were also determined. Levels of gene expression of GPX4, Nrf2, DMT1, ACSL4, and caspase3 genes were evaluated by using RT-qPCR. Finally, histopathological examination of rat heart tissues of different groups was done. After rutin treatment, our results revealed that TIBC, ferritin, transferrin, hepicidin, MDA&NO were significantly decreased, while GSH level and GPx&SOD activities were significantly increased. Also, rutin exerting its protective role by increasing GPX4&Nrf2 expressions and decreasing DMTN, ACSL4, and caspase3 expressions. Rutin can be proposed as a therapeutic candidate to attenuate ferroptosis.
DOI: 10.6084/m9.figshare.29040273.v1
title: Rutin attenuates iron overload induced-ferroptosis in rats’ heart tissue

description: Rutin is a natural flavonoid with antioxidant and iron chelating properties. Therefore, this study aimed to investigate the ameliorative effects of rutin against iron-overload and ionising radiation induced (IR)-ferroptosis in rats’ heart tissue. Rats were divided into nine groups; control, Rutin, IR, Fe, Fe + IR, Fe + Rutin, IR+Rutin, Fe + IR+Rutin and Fe + IR+Deferasirox. Serum iron profiles total iron, TIBC, ferritin, transferrin, and hepicidin were determined. Moreover, MDA, GSH, and NO levels and GPx, and SOD activities were also determined. Levels of gene expression of GPX4, Nrf2, DMT1, ACSL4, and caspase3 genes were evaluated by using RT-qPCR. Finally, histopathological examination of rat heart tissues of different groups was done. After rutin treatment, our results revealed that TIBC, ferritin, transferrin, hepicidin, MDA&NO were significantly decreased, while GSH level and GPx&SOD activities were significantly increased. Also, rutin exerting its protective role by increasing GPX4&Nrf2 expressions and decreasing DMTN, ACSL4, and caspase3 expressions. Rutin can be proposed as a therapeutic candidate to attenuate ferroptosis.
DOI: 10.21233/1v02-8x88
title: First diatom surface sample dataset

description: Raw data for the First diatom surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/ap3m-zw26
title: Ledrosee pollen dataset

description: Raw data for the Ledrosee pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/cqbd-w406
title: Hunter Island [ElTa-25] specimen stable isotope dataset

description: Raw data for the Hunter Island [ElTa-25] specimen stable isotope dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.21233/rvv2-r235
title: Wolf Lake diatom surface sample dataset

description: Raw data for the Wolf Lake diatom surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.6084/m9.figshare.28777699
title: Clinical benefit of PD-1/PD-L1 inhibitors for poor performance status patients with advanced non-small cell lung cancer

description: The benefit of programmed cell death protein-1 (PD-1)/programmed cell death protein ligand-1 (PD-L1) inhibitors remains unclear in non-small cell lung cancer (NSCLC) patients with poor performance status (PS). In the current multi-centre retrospective cohort study, advanced or recurrent NSCLC patients treated with PD-1/PD-L1 inhibitors were enrolled. Of the 219 patients enrolled, 44 had PS 2–4. The objective response rate (ORR) of patients with PS 2–4 in 1<sup>st</sup> line was 33%. Among 1<sup>st</sup> line group, median progression-free survival (PFS) in patients with PS 2 was significantly longer compared to that in patients with PS 3–4 (15.3 months vs. 0.9 months, P = 0.039, Log-rank test). Among previously treated patients, the ORR of patients with PS 2–4 was only 4%, and PFS and overall survival was poor even in patients with PS 2. PD-1/PD-L1 inhibitors can be an option for PS 2 NSCLC patients in 1<sup>st</sup> line setting.
DOI: 10.6084/m9.figshare.28777699.v2
title: Clinical benefit of PD-1/PD-L1 inhibitors for poor performance status patients with advanced non-small cell lung cancer

description: The benefit of programmed cell death protein-1 (PD-1)/programmed cell death protein ligand-1 (PD-L1) inhibitors remains unclear in non-small cell lung cancer (NSCLC) patients with poor performance status (PS). In the current multi-centre retrospective cohort study, advanced or recurrent NSCLC patients treated with PD-1/PD-L1 inhibitors were enrolled. Of the 219 patients enrolled, 44 had PS 2–4. The objective response rate (ORR) of patients with PS 2–4 in 1<sup>st</sup> line was 33%. Among 1<sup>st</sup> line group, median progression-free survival (PFS) in patients with PS 2 was significantly longer compared to that in patients with PS 3–4 (15.3 months vs. 0.9 months, P = 0.039, Log-rank test). Among previously treated patients, the ORR of patients with PS 2–4 was only 4%, and PFS and overall survival was poor even in patients with PS 2. PD-1/PD-L1 inhibitors can be an option for PS 2 NSCLC patients in 1<sup>st</sup> line setting.