cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21089047.v2
title: Densitometric analysis of the Ponceau stained blot and western blots.

description: Densitometric analysis of the Ponceau stained blot and western blot. The expression of HSP70 was quantified after normalization of the ponceau bands on PVDF membrane. C40 and S40 are the control and spermidine fed larave subjected to heat shock at 40 °C.
DOI: 10.5519/qd.a0uuxwiq
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (109 records)
DOI: 10.5519/qd.v56xzcfg
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (491 records)
DOI: 10.5281/zenodo.7074686
title: Maputo Bay: Marine Macroinvertebrates

description: A portion of a database (DB) provided by the COBIONET Project team (e.g. Niza <em>et al.</em>, 2021). Data sources included biodiversity repositories such as the Global Biodiversity Information Facility (GBIF), museum collections and scientific literature. The DB was already georeferenced (with every entry associated with a latitude and longitude), standardized according to a Darwin Core format, and validated. The original DB was cut for only accounting entries lying between the physical/ geomorphological boundaries of Maputo Bay (MB). The latitudes considered were between -26.10083 and -25.86053, whereas the longitudes ranged between 32.48915 and -25.86053. These resulting DB encompasses the following information for each occurrence: taxonomic level to genus or species; local (name and georeferences) and date of sampling; ecosystem type (e.g. mangrove, seagrass, etc.); habitat occupation; and trophic guild.
DOI: 10.5281/zenodo.7074685
title: Maputo Bay: Marine Macroinvertebrates

description: A portion of a database (DB) provided by the COBIONET Project team (e.g. Niza <em>et al.</em>, 2021). Data sources included biodiversity repositories such as the Global Biodiversity Information Facility (GBIF), museum collections and scientific literature. The DB was already georeferenced (with every entry associated with a latitude and longitude), standardized according to a Darwin Core format, and validated. The original DB was cut for only accounting entries lying between the physical/ geomorphological boundaries of Maputo Bay (MB). The latitudes considered were between -26.10083 and -25.86053, whereas the longitudes ranged between 32.48915 and -25.86053. These resulting DB encompasses the following information for each occurrence: taxonomic level to genus or species; local (name and georeferences) and date of sampling; ecosystem type (e.g. mangrove, seagrass, etc.); habitat occupation; and trophic guild.
DOI: 10.25418/crick.21089626
title: Immunocytochemistry (ICC) v1

description: This protocol describes how to do immunocytostochemistry for primary and hiPSC-derived cells.
DOI: 10.25418/crick.21089626.v1
title: Immunocytochemistry (ICC) v1

description: This protocol describes how to do immunocytostochemistry for primary and hiPSC-derived cells.
DOI: 10.5519/qd.7dzeo3n5
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (120 records)
DOI: 10.6084/m9.figshare.20088387
title: HIV-1 therapeutic vaccines in clinical development to intensify or replace antiretroviral therapy: the promising results of the Tat vaccine

description: Upon the introduction of the combination antiretroviral therapy (cART), HIV infection has become a chronic disease. However, cART is unable to eradicate the virus and fails to restore the CD4 counts in about 30% of the treated individuals. Furthermore, treatment is life-long, and it does not protect from morbidities typically observed in the elderly. Therapeutic vaccines represent the most cost-effective intervention to intensify or replace cART. Here, we briefly discuss the obstacles to the development and evaluation of the efficacy of therapeutic vaccines and review recent approaches evaluated in clinical trials. Although vaccines were generally safe and immunogenic, evidence of efficacy was negligible or marginal in most trials. A notable exception is the therapeutic Tat vaccine approach showing promising results of cART intensification, with CD4 T-cell increase and proviral load reduction beyond those afforded by cART alone. Rationale and evidence in support of choosing Tat as the vaccine target are thoroughly discussed.
DOI: 10.6084/m9.figshare.20088387.v1
title: HIV-1 therapeutic vaccines in clinical development to intensify or replace antiretroviral therapy: the promising results of the Tat vaccine

description: Upon the introduction of the combination antiretroviral therapy (cART), HIV infection has become a chronic disease. However, cART is unable to eradicate the virus and fails to restore the CD4 counts in about 30% of the treated individuals. Furthermore, treatment is life-long, and it does not protect from morbidities typically observed in the elderly. Therapeutic vaccines represent the most cost-effective intervention to intensify or replace cART. Here, we briefly discuss the obstacles to the development and evaluation of the efficacy of therapeutic vaccines and review recent approaches evaluated in clinical trials. Although vaccines were generally safe and immunogenic, evidence of efficacy was negligible or marginal in most trials. A notable exception is the therapeutic Tat vaccine approach showing promising results of cART intensification, with CD4 T-cell increase and proviral load reduction beyond those afforded by cART alone. Rationale and evidence in support of choosing Tat as the vaccine target are thoroughly discussed.
DOI: 10.6084/m9.figshare.20440269
title: Public health and budgetary impact of 20-valent pneumococcal conjugate vaccine for adults in England

description: Despite use of 23-valent pneumococcal polysaccharide vaccine (PPV23) in England, disease burden among at-risk adults remains high. We evaluated the public health and budgetary impact of 20-valent pneumococcal conjugate vaccine (PCV20) compared to the current adult pneumococcal vaccination program. Five-year outcomes and costs of invasive pneumococcal disease (IPD) and community-acquired pneumonia (CAP) among adults aged 65–99 years and adults aged 18–64 years with underlying conditions in England were projected using a deterministic cohort model. Hypothetical vaccination with PCV20 versus PPV23 was compared from the National Health Service (NHS) perspective. Replacing PPV23 with PCV20 would prevent 785 IPD hospitalizations, 11,751 CAP hospitalizations, and 1,414 deaths over 5 years, and would reduce medical care costs by £48.5 M. With vaccination costs higher by £107.2 M, projected net budgetary impact is £58.7 M. The budgetary impact would be greatest in year 1 (£26.3 M), and would decrease over time (to £1.6 M by year 5). The average budget increase (£11.7 M/year) represents &lt;0.01% of the Department of Health and Social Care total budget and &lt;3% of the vaccine budget. Use of PCV20 among adults currently eligible for PPV23 in England would substantially reduce the burden of pneumococcal disease, with modest budgetary impact.
DOI: 10.6084/m9.figshare.20440269.v2
title: Public health and budgetary impact of 20-valent pneumococcal conjugate vaccine for adults in England

description: Despite use of 23-valent pneumococcal polysaccharide vaccine (PPV23) in England, disease burden among at-risk adults remains high. We evaluated the public health and budgetary impact of 20-valent pneumococcal conjugate vaccine (PCV20) compared to the current adult pneumococcal vaccination program. Five-year outcomes and costs of invasive pneumococcal disease (IPD) and community-acquired pneumonia (CAP) among adults aged 65–99 years and adults aged 18–64 years with underlying conditions in England were projected using a deterministic cohort model. Hypothetical vaccination with PCV20 versus PPV23 was compared from the National Health Service (NHS) perspective. Replacing PPV23 with PCV20 would prevent 785 IPD hospitalizations, 11,751 CAP hospitalizations, and 1,414 deaths over 5 years, and would reduce medical care costs by £48.5 M. With vaccination costs higher by £107.2 M, projected net budgetary impact is £58.7 M. The budgetary impact would be greatest in year 1 (£26.3 M), and would decrease over time (to £1.6 M by year 5). The average budget increase (£11.7 M/year) represents &lt;0.01% of the Department of Health and Social Care total budget and &lt;3% of the vaccine budget. Use of PCV20 among adults currently eligible for PPV23 in England would substantially reduce the burden of pneumococcal disease, with modest budgetary impact.
DOI: 10.6084/m9.figshare.20207856
title: Expert review on global real-world vaccine effectiveness against SARS-CoV-2

description: COVID-19 vaccines have been highly effective in reducing morbidity and mortality during the pandemic. While primary series vaccination rates are generally high in Southeast Asian (SEA) countries, various factors have limited the rollout and impact of booster doses. We reviewed 79 studies in the International Vaccine Access Center (IVAC) VIEW-hub platform on vaccine effectiveness (VE) after primary immunizations with two-dose schedules. VE data were reported for SARS-CoV-2 infection, COVID-19-related hospitalizations and deaths, and stratified across variants of concern, age, study design and prior SARS-CoV-2 infection for mRNA vaccines (BNT162b2, mRNA-1273, and combinations of both), vector vaccines (AstraZeneca, AZD1222 [ChAdOx1 nCoV-19] ‘Vaxzevria’), and inactivated virus vaccines (CoronaVac). The most-studied COVID-19 vaccines provide consistently high (&gt;90%) protection against serious clinical outcomes like hospitalizations and deaths, regardless of variant. Additionally, this protection appears equivalent for mRNA vaccines and vector vaccines like AZD1222, as supported by our analysis of Asian and relevant international data, and by insights from SEA experts. Given the continued impact of COVID-19 hospitalizations and deaths on health-care systems worldwide, encouraging vaccination strategies that reduce this burden is more relevant than attempting to prevent broader but milder infections with specific variants, including Omicron.
DOI: 10.6084/m9.figshare.20207856.v1
title: Expert review on global real-world vaccine effectiveness against SARS-CoV-2

description: COVID-19 vaccines have been highly effective in reducing morbidity and mortality during the pandemic. While primary series vaccination rates are generally high in Southeast Asian (SEA) countries, various factors have limited the rollout and impact of booster doses. We reviewed 79 studies in the International Vaccine Access Center (IVAC) VIEW-hub platform on vaccine effectiveness (VE) after primary immunizations with two-dose schedules. VE data were reported for SARS-CoV-2 infection, COVID-19-related hospitalizations and deaths, and stratified across variants of concern, age, study design and prior SARS-CoV-2 infection for mRNA vaccines (BNT162b2, mRNA-1273, and combinations of both), vector vaccines (AstraZeneca, AZD1222 [ChAdOx1 nCoV-19] ‘Vaxzevria’), and inactivated virus vaccines (CoronaVac). The most-studied COVID-19 vaccines provide consistently high (&gt;90%) protection against serious clinical outcomes like hospitalizations and deaths, regardless of variant. Additionally, this protection appears equivalent for mRNA vaccines and vector vaccines like AZD1222, as supported by our analysis of Asian and relevant international data, and by insights from SEA experts. Given the continued impact of COVID-19 hospitalizations and deaths on health-care systems worldwide, encouraging vaccination strategies that reduce this burden is more relevant than attempting to prevent broader but milder infections with specific variants, including Omicron.
DOI: 10.25418/crick.21089686
title: Preparation of primary rat cortical neuron and astrocyte co-culture v1

description: This protocol describes how to prepare primary rat cortical neuron and astrocyte co-culture.
DOI: 10.25418/crick.21089686.v1
title: Preparation of primary rat cortical neuron and astrocyte co-culture v1

description: This protocol describes how to prepare primary rat cortical neuron and astrocyte co-culture.
DOI: 10.5517/ccdc.csd.cc24cyzg
title: CCDC 1977706: Experimental Crystal Structure Determination

description: Related Article: Jiwei Wang, Lin Liu, Licheng Zhan, Jun Zhang|2022|Inorg.Chem.Front.|9|4801|doi:10.1039/D2QI00357K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc24cz2l
title: CCDC 1977709: Experimental Crystal Structure Determination

description: Related Article: Jiwei Wang, Lin Liu, Licheng Zhan, Jun Zhang|2022|Inorg.Chem.Front.|9|4801|doi:10.1039/D2QI00357K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt3t
title: CCDC 2103446: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt4v
title: CCDC 2103447: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt5w
title: CCDC 2103448: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt6x
title: CCDC 2103449: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt7y
title: CCDC 2103450: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt8z
title: CCDC 2103451: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lt90
title: CCDC 2103452: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28ltb1
title: CCDC 2103453: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28ltc2
title: CCDC 2103454: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28ltd3
title: CCDC 2103455: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28ltf4
title: CCDC 2103456: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28ltg5
title: CCDC 2103457: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28lth6
title: CCDC 2103458: Experimental Crystal Structure Determination

description: Related Article: Yu-Ying Yang, Xiao-Quan Zhu, Yong Wang, Xin-Tao Wu, Tian-Lu Sheng|2022|Inorg.Chem.Front.|9|4732|doi:10.1039/D2QI00909A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28wswv
title: CCDC 2112088: Experimental Crystal Structure Determination

description: Related Article: Xiao Yang, Shihui Wang, Lei Xu, Qiang Yan, Chao Xu, Petr Matveev, Lecheng Lei, Chengliang Xiao|2022|Inorg.Chem.Front.|9|4671|doi:10.1039/D2QI01153K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28wt11
title: CCDC 2112093: Experimental Crystal Structure Determination

description: Related Article: Xiao Yang, Shihui Wang, Lei Xu, Qiang Yan, Chao Xu, Petr Matveev, Lecheng Lei, Chengliang Xiao|2022|Inorg.Chem.Front.|9|4671|doi:10.1039/D2QI01153K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28wt22
title: CCDC 2112094: Experimental Crystal Structure Determination

description: Related Article: Xiao Yang, Shihui Wang, Lei Xu, Qiang Yan, Chao Xu, Petr Matveev, Lecheng Lei, Chengliang Xiao|2022|Inorg.Chem.Front.|9|4671|doi:10.1039/D2QI01153K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28wt33
title: CCDC 2112095: Experimental Crystal Structure Determination

description: Related Article: Xiao Yang, Shihui Wang, Lei Xu, Qiang Yan, Chao Xu, Petr Matveev, Lecheng Lei, Chengliang Xiao|2022|Inorg.Chem.Front.|9|4671|doi:10.1039/D2QI01153K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.