cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10677071
title: asyn_hsp70_Ch5_data

description: Repository which contains example unprocessed, and partially processed data for use with the code found at https://zenodo.org/doi/10.5281/zenodo.10677095 (asyn_hsp70_Ch5). This data pertains to the analysis of TIRF microscopy data which visualises the binding of fluorescently-labelled chaperones to alpha-synuclein fibrils. It can be downloaded using scripts within the associated repository and used to explore the analysis workflow described there.
DOI: 10.5281/zenodo.10677072
title: asyn_hsp70_Ch5_data

description: Repository which contains example unprocessed, and partially processed data for use with the code found at https://zenodo.org/doi/10.5281/zenodo.10677095 (asyn_hsp70_Ch5). This data pertains to the analysis of TIRF microscopy data which visualises the binding of fluorescently-labelled chaperones to alpha-synuclein fibrils. It can be downloaded using scripts within the associated repository and used to explore the analysis workflow described there.
DOI: 10.6084/m9.figshare.25239463
title: ObitrapOriginalData.zip

description: Proteomic analysis for freshly purified Prochlorococcus MED4 carboxysome was performed via Orbitrap Eclipse Tribrid Mass Spectrometry (Thermo Scientific).
DOI: 10.6084/m9.figshare.25239463.v2
title: ObitrapOriginalData.zip

description: Proteomic analysis for freshly purified Prochlorococcus MED4 carboxysome was performed via Orbitrap Eclipse Tribrid Mass Spectrometry (Thermo Scientific).
DOI: 10.6084/m9.figshare.25239463.v1
title: ObitrapOriginalData.zip

description: Proteomic analysis for freshly purified Prochlorococcus MED4 carboxysome was performed via Orbitrap Eclipse Tribrid Mass Spectrometry (Thermo Scientific).
DOI: 10.5281/zenodo.10457134
title: Law Indexes: Maine

description: As part of efforts to expand the Local Geohistory Project, which aims to educate users and disseminate information concerning the geographic history and structure of political subdivisions and local government, this respository has been created to disseminate law index data for the State of Maine. This index currently covers private and special laws only from 1820 through 1957.
Private and special laws concern one or several individuals, entities, or localities, unlike public or general laws, which apply to all similarly situated individuals, entities, and localities within a jurisdiction. Throughout New England, private and special laws were often the primary method used to alter municipal and county boundaries and forms of government.
The law index is released as a tab-separated values (TSV) file, output/MeLawIndex.tsv. The Detail column may contain additional Prefix information that is repeated from prior entries.
This repository does not contain the full text of the laws, nor does it currently contain links to the full text. Because the index was created using OCR technology, it may contain uncaptured errors.
DOI: 10.5281/zenodo.10457146
title: Law Indexes: Maine

description: As part of efforts to expand the Local Geohistory Project, which aims to educate users and disseminate information concerning the geographic history and structure of political subdivisions and local government, this respository has been created to disseminate law index data for the State of Maine. This index currently covers private and special laws only from 1820 through 1957.
Private and special laws concern one or several individuals, entities, or localities, unlike public or general laws, which apply to all similarly situated individuals, entities, and localities within a jurisdiction. Throughout New England, private and special laws were often the primary method used to alter municipal and county boundaries and forms of government.
The law index is released as a tab-separated values (TSV) file, output/MeLawIndex.tsv. The Detail column may contain additional Prefix information that is repeated from prior entries.
This repository does not contain the full text of the laws, nor does it currently contain links to the full text. Because the index was created using OCR technology, it may contain uncaptured errors.
DOI: 10.5281/zenodo.10677143
title: Model for the paper: Cause of enigmatic upper-mantle earthquakes in central Wyoming

description: We use a large number of high-quality arrival-time data of local and teleseismic events to determine detailed 3-D Vp isotropic and anisotropic tomography of the crust and mantle down to 750 km depth beneath Wyoming and its adjacent areas. For details, see https://doi.org/10.1785/0220230333

This dataset contains the obtained 3-D tomographic models of isotropic P-wave velocity, azimuthal anisotropy and radial anisotropy.
DOI: 10.5281/zenodo.8280776
title: Model for the paper: Cause of enigmatic upper-mantle earthquakes in central Wyoming

description: We use a large number of high-quality arrival-time data of local and teleseismic events to determine detailed 3-D Vp isotropic and anisotropic tomography of the crust and mantle down to 750 km depth beneath Wyoming and its adjacent areas. For details, see https://doi.org/10.1785/0220230333

This dataset contains the obtained 3-D tomographic models of isotropic P-wave velocity, azimuthal anisotropy and radial anisotropy.
DOI: 10.5281/zenodo.8280777
title: Model for the paper: Slab-plume interaction and 2013 Wyoming upper-mantle earthquakes

description: We use a large number of high-quality arrival-time data of local and teleseismic events to determine detailed 3-D Vp isotropic and anisotropic tomography of the crust and mantle down to 750 km depth beneath Wyoming and its adjacent areas. This dataset contains the obtained 3-D tomographic models of isotropic P-wave velocity, azimuthal anisotropy and radial anisotropy.
DOI: 10.6084/m9.figshare.25242756
title: Genetic confounds of transgenerational epigenetic inheritance in mice

description: Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to modify DNA methylation levels at specific promoters and then demonstrating the inheritance of the gain in methylation in offspring. In this technical commentary, we argue that the method used in the original study inherently amplifies the likelihood of genetic changes that thereafter lead to the heritability of epigenetic changes. We provide evidence that genetic changes from multiple sources do indeed occur in these experiments and explore several avenues by which these changes could be causal to the apparent inheritance of epigenetic changes. We conclude a genetic basis of inheritance cannot be ruled out and thus transgenerational epigenetic inheritance has not been adequately established by the original study.
DOI: 10.6084/m9.figshare.25242756.v1
title: Genetic confounds of transgenerational epigenetic inheritance in mice

description: Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to modify DNA methylation levels at specific promoters and then demonstrating the inheritance of the gain in methylation in offspring. In this technical commentary, we argue that the method used in the original study inherently amplifies the likelihood of genetic changes that thereafter lead to the heritability of epigenetic changes. We provide evidence that genetic changes from multiple sources do indeed occur in these experiments and explore several avenues by which these changes could be causal to the apparent inheritance of epigenetic changes. We conclude a genetic basis of inheritance cannot be ruled out and thus transgenerational epigenetic inheritance has not been adequately established by the original study.
DOI: 10.6084/m9.figshare.25242755
title: Association of changes in expression of <i>HDAC</i> and <i>SIRT</i> genes after drug treatment with cancer cell line sensitivity to kinase inhibitors

description: Histone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such transcriptional changes affect tumour sensitivity to drug treatment. We investigated the concerted transcriptional response of <i>HDAC</i> and <i>SIRT</i> genes to 15 approved antitumor agents in the NCI-60 cancer cell line panel. Antitumor agents with diverse mechanisms of action induced upregulation or downregulation of multiple <i>HDAC</i> and <i>SIRT</i> genes. <i>HDAC5</i> was upregulated by dasatinib and erlotinib in the majority of the cell lines. Tumour cell line sensitivity to kinase inhibitors was associated with upregulation of <i>HDAC5, HDAC1</i>, and several <i>SIRT</i> genes. We confirmed changes in <i>HDAC</i> and <i>SIRT</i> expression in independent datasets. We also experimentally validated the upregulation of HDAC5 mRNA and protein expression by dasatinib in the highly sensitive IGROV1 cell line. HDAC5 was not upregulated in the UACC-257 cell line resistant to dasatinib. The effects of cancer drug treatment on expression of <i>HDAC</i> and <i>SIRT</i> genes may influence chemosensitivity and may need to be considered during chemotherapy.
DOI: 10.6084/m9.figshare.25242755.v1
title: Association of changes in expression of <i>HDAC</i> and <i>SIRT</i> genes after drug treatment with cancer cell line sensitivity to kinase inhibitors

description: Histone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such transcriptional changes affect tumour sensitivity to drug treatment. We investigated the concerted transcriptional response of <i>HDAC</i> and <i>SIRT</i> genes to 15 approved antitumor agents in the NCI-60 cancer cell line panel. Antitumor agents with diverse mechanisms of action induced upregulation or downregulation of multiple <i>HDAC</i> and <i>SIRT</i> genes. <i>HDAC5</i> was upregulated by dasatinib and erlotinib in the majority of the cell lines. Tumour cell line sensitivity to kinase inhibitors was associated with upregulation of <i>HDAC5, HDAC1</i>, and several <i>SIRT</i> genes. We confirmed changes in <i>HDAC</i> and <i>SIRT</i> expression in independent datasets. We also experimentally validated the upregulation of HDAC5 mRNA and protein expression by dasatinib in the highly sensitive IGROV1 cell line. HDAC5 was not upregulated in the UACC-257 cell line resistant to dasatinib. The effects of cancer drug treatment on expression of <i>HDAC</i> and <i>SIRT</i> genes may influence chemosensitivity and may need to be considered during chemotherapy.
DOI: 10.5281/zenodo.7512511
title: Differential gas transport in shale nanochannels: helium, nitrogen, and methane

description: Measured Longmaxi shale core's apparent permeabilities for helium, nitrogen, and methane at various confining and pore pressures, and fitting parameters of response surface model.
DOI: 10.5281/zenodo.7512512
title: Differential gas transport in shale nanochannels: helium, nitrogen, and methane

description: Measured Longmaxi shale core's apparent permeabilities for helium, nitrogen, and methane at various confining and pore pressures, and fitting parameters of response surface model.
DOI: 10.6084/m9.figshare.21559122
title: Dataset of comparison value of ToucHB device and Automated complete blood (CBC) examination

description: A prospective diagnostic evaluation study of ToucHB device was designed and implemented at the central laboratory of Krishna Rajendra hospital attached to the Mysore Medical College and Research Institute, Mysore, India.
DOI: 10.6084/m9.figshare.21559122.v1
title: Dataset of comparison value of ToucHB device and Automated complete blood (CBC) examination

description: A prospective diagnostic evaluation study of ToucHB device was designed and implemented at the central laboratory of Krishna Rajendra hospital attached to the Mysore Medical College and Research Institute, Mysore, India.
DOI: 10.34740/kaggle/dsv/7653713
title: Contrastive Language Image Pretraining by openai
DOI: 10.6084/m9.figshare.25242805
title: A novel time-dependent electric vehicle pickup and delivery problem with time windows in cold supply chains

description: This is the dataset of the manuscript named "A novel time-dependent electric vehicle pickup and delivery problem with time windows in cold supply chains".
DOI: 10.6084/m9.figshare.25242832
title: Travel speed dataset of "A novel time-dependent electric vehicle pickup and delivery problem with time windows in cold supply chains"

description: This is the travel speed dataset for the the manuscript entitled “ A novel time-dependent electric vehicle pickup and delivery problem with time windows in cold supply chains ”.
DOI: 10.6084/m9.figshare.25242832.v1
title: Travel speed dataset of "A novel time-dependent electric vehicle pickup and delivery problem with time windows in cold supply chains"

description: This is the travel speed dataset for the the manuscript entitled “ A novel time-dependent electric vehicle pickup and delivery problem with time windows in cold supply chains ”.
DOI: 10.15151/esrf-es-1440746196
title: Crystallographic projects at Structural Biology Core Facility, JU - bringing the state of art support to the users in need.

description: Structural biology is very informative discipline providing strong support to virtually any biochemistry related project, however in many cases a lack of expertise is a barrier limiting application of structural biology techniques in the most exciting projects. Foundation of Structural Biology Core Facility (SBCF) at Jagiellonian University (JU, Krakow, Poland) was motivated by a need of providing a support of local experts to biochemists who could potentially benefit from detailed knowledge of their proteins of interest. SBCF is based on two pillars - cryo-EM and macromolecular crystallography. The later being conducted with the use of state-of-art beamlines at European synchrotron radiation sources. Since 2019 SBCF assisted in over 30 peer-reviewed publications. With this proposal we'd like to apply for an access to state of the art crystallographic bemlines at ESRF to help our user community to benefit from the brightest and most advanced X-ray sources in Europe.
DOI: 10.15151/esrf-es-1520434104
title: Morphology of sheep enthesis and 3D imaging of materials

description: - Study for the morphological characterization of sheep enthesis linked to user experiment at ID19 (LS3260)
- Feasibility measurements on solid-state batteries
- Feasibility measurements on 3D printed ceramics
- Feasibility study of shale specimens
DOI: 10.15151/esrf-es-1439270746
title: Phase transition kinetics in spheroidal graphite irons.

description: We plan to measure in-situ liquid-solid and solid-solid phase transitions in Fe-Si-C-alloys in the proposed experiment. One objective is to determine the undercooling for γ-Fe and graphite nucleation as a function of alloy composition and inoculation by ceramic microparticles, previously evaluated in SEM and TEM (see Figure 1). Also, the kinetics of the eutectic and eutectoid transitions will be recorded at fixed cooling rates as a function of crystallographic change: amorphous to γ-Fe in the eutectic (~1150 °C), and γ-Fe to α-Fe (~800 °C) in the eutectoid.
DOI: 10.15151/esrf-es-1439273441
title: EBS-enabled magnetic BCDI of domains in Sr2IrO4

description: Bragg coherent diffraction imaging (BCDI) uniquely enables the study of small crystalline samples with high strain sensitivity (~2 × 10−4) and high spatial resolution (~10 nm) in three-dimensions (3D). Here we propose to use BCDI to image magnetic domains within a single crystal of Sr2IrO4, a high-temperature superconductor (HTSC) analogue. We plan to image the (106) magnetic Bragg peak to observe the evolution of 3D antiferromagnetic (AFM) domains in real space, complemented by collecting normal charge (116) Bragg peaks below and above TN = 225K. The two peaks will provide information on how magnetic domains evolve as a function of temperature, and how they are pinned to any defects in the lattice or are confined by the crystal morphology. This experiment will study the evolution of 3D magnetic domains and domain walls to understand fundamental magnetic interactions that make iridates analogous to superconducting cuprates.
DOI: 10.15151/esrf-es-1439273507
title: Single Crystal X-Ray Diffraction Investigation of High Tc Sc-H Mixtures

description: Recent experiments have demonstrated an astonishing close-to-room-temperature superconductivity (Tc ~ 250 K) in laser-heated Y-H and La-H mixtures between 170 GPa and 200 GPa. While this is a game-changer in our understanding of condensed matter physics, these pressures are far too high for technological applications. Scandium hydrides, which are largely unexplored experimentally at high pressures, are predicted by computational calculations to also form several high-Tc superconducting new structures, including a promising ScH12 solid with a calculated Tc of 313 K below 100 GPa. The here proposed study will investigate laser-heated Sc-H mixtures between 40 and 250 GPa, in pursuit of the theoretically predicted wealth of Sc-H stoichiometries and structures, some featuring very high Tc values. Unit cell and Sc atom’s arrangement will be extracted by single-crystal X-ray diffraction sample characterization.
DOI: 10.15151/esrf-es-1439273893
title: Real time 3D imaging of interfacial fluctuation-dynamics during imbibition into porous media.

description: Imbibition of wetting liquids into porous media is a topic of great scientific interest due to its geological, environmental, biological, and daily life importance. Recent developments in X-ray techniques enable in situ imaging imbibition in 4D (3D + time). During imbibition, many rapid events take place at the interfaces between fluids and the solid matrix. Pore filling events happen rapidly in milliseconds, posing a challenge for real-time 3D monitoring. Consequently, 3D imaging has been mostly restricted to equilibrium states before and after the process. We propose to study a) forced and b) spontaneous imbibition of wetting phase fluid into porous media using our recently proposed stroboscopic method for non-destructive real-time 3D imaging of fast pore-scale events. These studies are scientifically valuable as they enable real time monitoring of fundamental imbibition dynamics at their native temporal and spatial scales, allowing proposed theoretical models to be challenged.
DOI: 10.15151/esrf-es-1438786078
title: Using Texture tomography to understand the co-organization of mineral and collagen in the enthesis

description: The enthesis is the insertion site of tendon into bone and it plays a major role in biomechanics of load transfer in our bodies. It has a complicated, hierarchical structure and a graduation of the collagen, mineral properties and orientations. The organization and function of these gradients are still not fully understood. This is due to the complex, 3D organization of the mineralized tissue which is difficult to study in 3D. To this end, we are currently developing Texture tomography to study the crystallographic texture in 3D. With this technique, we will understand the crystalline texture of the mineral in mouse achilles tendon enthesis (ATE) and compare it to the organization of the collagen fibrils on the nanoscale measured by SAXS tensor tomography. By studying the ATE in three states (healthy, unloaded, reloaded) the impact of loading on the nanostructural organization can be probed to eventually use the biomechanical knowledge for an improved treatment of enthesis injuries.
DOI: 10.15151/esrf-es-1438787924
title: Ferric Iron in serpentinites as proxy for abiotic H2 production

description: Serpentinization is considered as among the most important processes sustaining redox conditions suitable for the synthesis of natural H2 and abiotic CH4. This process is documented at mid ocean ridges but also occur in subduction zones. In the latter context the potential for serpentinization to generate natural H2 and abiotic CH4 is not well understood. Since the release of reduced fluids is guided by the oxidation of ferrous iron into ferric iron hosted in secondary minerals (mainly serpentine and magnetite), the definition of the Fe3+/FeTot ratio in high-pressure serpentinites is fundamental to provide new insights on the magnitude of redox transformation and the related deep H2-CH4 formation in subduction zones. Here, we aim to determine the Fe3+/FeTot concentration by looking at the Fe K-edge pre-edge feature in different arrays of minerals formed in ancient subduction zones, now exhumed to the surface.
DOI: 10.15151/esrf-es-1438788181
title: Local structure and density of (Mg,Fe)SiO3 glasses up to 250 GPa

description: Physical properties of liquid silicates under extreme conditions are of first importance in geophysics, to constrain the early molten stage as well as to understand the seismic anomalies detected nowadays at the Earth's Core-Mantle Boundary. It is however extremely challenging to measure accurate melt structure over 100 GPa, therefore the analogy with compressed glass is often used. 
Thanks to the unique capabilities of ID27 High pressure beamline (Multichannel collimator and high brilliance pink beam), our group would like to measure precise structure factor of (Mg,Fe)SiO3 glass up to 250 GPa, to understand the effect of Fe on density and local structure of glass. This dataset will be finally compared with recent XRD data of laser shocked liquid silicates patterns recorded at LCLS, in order to assess analogy and differences betweeen liquid and amorphous silicates.
DOI: 10.15151/esrf-es-1437868349
title: Acoustic velocites of CaSiO3 perovskite

description: We propose to measure the acoustic velocity of Ti- and/or Al-bearing calcium perovskite (capv), the 3rd most abundant mineral in the lower mantle. The two published studies of capv’s elastic properties have a significantly different temperature dependence, and both diverge significantly from computational results. Our previous work was one of these, reporting vp and vs of capv to ~ 13 GPa & 1500 K on ID06-LVP (see ES-464 and ES-636 reports). We now propose to extend this study, to determine the thermo-elastic properties of capv at pressures extending to 30-35 GPa. Data will overlap conditions of previous work to remeasure temperature derivatives as well as clarifying the pressure dependance of capv’s thermo-elastic properties for more reliable extrapolation to the deep lower mantle. This will contribute directly to the interpretation of lower mantle seismic heterogeneities, and provide a mechanism for fingerprinting recycled material throughout Earth’s mantle.
DOI: 10.15151/esrf-es-1438316906
title: Using long bone histology to illuminate the emergence of mammal reproductive life histories

description: This study will identify long-term evolutionary developments in mammal reproductive strategy, reflected in the microstructures of long bones. These strategies have fundamentally influenced the macroevolution of mammals since their emergence in the Mesozoic, but the timing and pattern of their emergence remains one of the major unanswered questions in palaeontology. Our study of histological microstructures in the femora and humeri of early mammals will be compared with representatives of the three major groups of living mammals: placentals, marsupials, and monotremes. Previous studies were restricted in terms of sample size and taxonomy due to the destructive nature of traditional histological preparation techniques. The use of non-destructive SRCT mapping will permit us to examine a broad collection of fossil mammals spanning the Late Triassic (~205 mya) to Late Cretaceous (90 mya), as well as extant monotremes – the latter omitted from previous studies.