cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11662938
title: A new Co(II)-based coordination polymer: crystal structure and treatment activity on Alzheimer’s disease by reducing the accumulation of Aβ

description: A new coordination polymer, namely, [Co<sub>2</sub>(L)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]<sub>n</sub>·nH<sub>2</sub>O (<b>1</b>) (H<sub>2</sub>L = 5-(1H-1,2,4-triazol-1-yl)-1,3-benzenedicarboxylic acid), was synthesized via the reaction of H<sub>2</sub>L and Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O at pH value of 3.6 under the hydrothermal conditions. In addition, a technique of green hand grinding was carried out to decrease complex <b>1</b>’s particle size, resulting in the formation of nanoscale <b>1</b> (denoted as nano <b>1</b> hereafter) with ball-like morphology. Furthermore, the prevention and treatment ability of the compound on the Alzheimer’s disease (AD) was evaluated and the related mechanism was discussed. First, the animal model AD of was established within mice, then brain weight along with volume was measured after compound treatment. Besides, the content of the Amyloid (Aβ) was detected to reveal the mechanism and the target of the compound.
DOI: 10.6084/m9.figshare.11662938.v1
title: A new Co(II)-based coordination polymer: crystal structure and treatment activity on Alzheimer’s disease by reducing the accumulation of Aβ

description: A new coordination polymer, namely, [Co<sub>2</sub>(L)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]<sub>n</sub>·nH<sub>2</sub>O (<b>1</b>) (H<sub>2</sub>L = 5-(1H-1,2,4-triazol-1-yl)-1,3-benzenedicarboxylic acid), was synthesized via the reaction of H<sub>2</sub>L and Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O at pH value of 3.6 under the hydrothermal conditions. In addition, a technique of green hand grinding was carried out to decrease complex <b>1</b>’s particle size, resulting in the formation of nanoscale <b>1</b> (denoted as nano <b>1</b> hereafter) with ball-like morphology. Furthermore, the prevention and treatment ability of the compound on the Alzheimer’s disease (AD) was evaluated and the related mechanism was discussed. First, the animal model AD of was established within mice, then brain weight along with volume was measured after compound treatment. Besides, the content of the Amyloid (Aβ) was detected to reveal the mechanism and the target of the compound.
DOI: 10.6084/m9.figshare.11662950.v2
title: Brain abscess: clinical, radiological and microbiological data for a retrospective UK cohort

description: These files are the supporting metadata for a retrospective analysis of a clinical cohort of adults with a diagnosis of bacterial brain abscess at Oxford University Hospitals NHS Foundation Trust, in the UK. The study was locally approved as a clinical audit.<br>The xls file contains the clinical metadata reported by our study.<br>We have provided a STROBE statement (Strengthening the Reporting of Observational Studies in Epidemiology)<br>The supplementary data file (pdf) contains the following information:<br><b>Suppl Figure 1: </b>CONSORT diagram for identification of a cohort of adults with brain abscesses from a tertiary referral hospital in the UK. <br><b>Suppl Fig 2: </b>Duration of antibiotic therapy for adults treated for bacterial brain abscess<br><b>Suppl Table 1: </b>Association between S. milleri infection and other patient characteristics in a cohort of 39 adults with positive microbiology diagnosis of bacterial brain abscess<br><b>Suppl Table 2</b>: Number of surgical interventions undertaken for 47 adults presenting with brain abscess<br>
DOI: 10.6084/m9.figshare.11662914
title: Hexavalent chromium and stomach cancer: a systematic review and meta-analysis

description: Hexavalent chromium [Cr(VI)] is known to cause lung cancer in workers of certain industries, but an association with stomach cancer is uncertain and widely debated. Systematic review and meta-analyses were conducted to assess the risk of stomach cancer mortality/morbidity in humans and experimental animals exposed to Cr(VI). In accordance with the protocol (PROSPERO #CRD4201605162), searches in PubMed and Embase<sup>®</sup>, and reviews of secondary literature bibliographies, were used to identify eligible studies. Critical appraisal of internal validity and qualitative integration were carried out using the National Toxicology Program’s Office of Health Assessment and Translation (OHAT) approach; meta-analyses were conducted based on the occupational data (the only data suitable for quantitative assessment). Forty-seven publications (3 animal, 44 occupational, 0 non-occupational) met the eligibility criteria. Stomach cancer was only observed in one high risk of bias animal study, and in the low risk of bias studies no stomach cancer was observed. Thus, confidence in this evidence base is high. Environmental epidemiology studies did not meet eligibility criteria because exposure and outcome were not measured at the individual level. Meta-analyses of human data resulted in overall meta relative risks of 1.08 (95% CI: 0.96–1.21) including all studies and 1.03 (95%CI: 0.84–1.26) excluding studies associated with the highest risk of bias. Because most occupational studies have high risk of bias for confounding and exposure domains, the overall confidence in this evidence base is low to moderate. Combining the streams of evidence per the OHAT approach, Cr(VI) does not pose a stomach cancer hazard in humans.
DOI: 10.6084/m9.figshare.11662860
title: Preprocessed_Datasets.zip

description: Imaging of mouse embryonic hearts using a customized vertical light-sheet microscope
DOI: 10.6084/m9.figshare.11662854
title: questionnaires_18.xlsx

description: Questionnaire data on well-being in bark beetle impacted forests<br>
DOI: 10.6084/m9.figshare.11662860.v1
title: Preprocessed_Datasets.zip

description: Imaging of mouse embryonic hearts using a customized vertical light-sheet microscope
DOI: 10.17028/rd.lboro.11662845
title: Supplementary Information Files for 'The influence of climate change on the restoration trajectory of a nutrient-rich deep lake'

description: Supplementary Information Files for 'The influence of climate change on the restoration trajectory of a nutrient-rich deep lake'<br>Abstract:Nutrient reduction in impacted lowland freshwater systems is ecologically and culturally important. Gaining a greater insight into how lakes respond to lowering nutrient loads and how climate-driven physical limnology affects present and future cycling of available nutrients is important for ecosystem resource management. This study examines the nutrient decline in a hypereutrophic freshwater lake (Rostherne Mere, Cheshire, UK) 25 years after sewage effluent diversion, a uniquely long-term analysis of a recovering nutrient-rich deep lake. Using nutrient, phytoplankton, climate and catchment hydrological monitoring, the contemporary lake system is compared to previous studies from 1990 to 2002. Nutrient change since point source load diversion showed annual average and maximum phosphorus (P) concentrations decreased significantly for the first 10 years (1992: ~ 600 µg P L−1; 2002: ~ 200 µg P L−1), but have since stabilised due to a substantial legacy sediment P internal load. Dissolved inorganic nitrogen (DIN) concentrations have not substantially changed since diversion, resulting in the alteration of the DIN/SRP ratio from a system characterised by N limitation (N:P ~ 5), to one predominantly P limited (N:P &gt; 20). Nutrient changes over this time are shown to drive ecological change, especially in the cyanobacterial and algal communities. Furthermore, very high-resolution monitoring of lake inflow and outflow (every 5 min during 2016) shows that water residence time at this lake is significantly shorter than previously estimated (~ 0.8 years compared to previous estimates of ~ 1.6–2.4 years). Together with long-term data demonstrating that the stratification period at Rostherne Mere has increased by 40 days over the last ~ 50 years (due to later autumnal mixing), we show that a rapid rate of epilimnetic flushing together with a long stratification period substantially reduces the available epilimnetic P during the summer cyanobacterial bloom. This is of growing importance for many such lakes, given widespread climate-driven lengthening of stratification and a national trend of decreasing summer rainfall (decreasing seasonal flushing) but more intense summer storm events (resulting in short-term flushing events).<br>
DOI: 10.17028/rd.lboro.11662845.v1
title: Supplementary Information Files for 'The influence of climate change on the restoration trajectory of a nutrient-rich deep lake'

description: Supplementary Information Files for 'The influence of climate change on the restoration trajectory of a nutrient-rich deep lake'<br>Abstract:Nutrient reduction in impacted lowland freshwater systems is ecologically and culturally important. Gaining a greater insight into how lakes respond to lowering nutrient loads and how climate-driven physical limnology affects present and future cycling of available nutrients is important for ecosystem resource management. This study examines the nutrient decline in a hypereutrophic freshwater lake (Rostherne Mere, Cheshire, UK) 25 years after sewage effluent diversion, a uniquely long-term analysis of a recovering nutrient-rich deep lake. Using nutrient, phytoplankton, climate and catchment hydrological monitoring, the contemporary lake system is compared to previous studies from 1990 to 2002. Nutrient change since point source load diversion showed annual average and maximum phosphorus (P) concentrations decreased significantly for the first 10 years (1992: ~ 600 µg P L−1; 2002: ~ 200 µg P L−1), but have since stabilised due to a substantial legacy sediment P internal load. Dissolved inorganic nitrogen (DIN) concentrations have not substantially changed since diversion, resulting in the alteration of the DIN/SRP ratio from a system characterised by N limitation (N:P ~ 5), to one predominantly P limited (N:P &gt; 20). Nutrient changes over this time are shown to drive ecological change, especially in the cyanobacterial and algal communities. Furthermore, very high-resolution monitoring of lake inflow and outflow (every 5 min during 2016) shows that water residence time at this lake is significantly shorter than previously estimated (~ 0.8 years compared to previous estimates of ~ 1.6–2.4 years). Together with long-term data demonstrating that the stratification period at Rostherne Mere has increased by 40 days over the last ~ 50 years (due to later autumnal mixing), we show that a rapid rate of epilimnetic flushing together with a long stratification period substantially reduces the available epilimnetic P during the summer cyanobacterial bloom. This is of growing importance for many such lakes, given widespread climate-driven lengthening of stratification and a national trend of decreasing summer rainfall (decreasing seasonal flushing) but more intense summer storm events (resulting in short-term flushing events).<br>
DOI: 10.6084/m9.figshare.11662794
title: Data set for "Structural variation of forest edges across Europe"

description: Data for the paper on 'Structural variation of forest edges across Europe'<br>
DOI: 10.6084/m9.figshare.11662794.v1
title: Data set for "Structural variation of forest edges across Europe"

description: Data for the paper on 'Structural variation of forest edges across Europe'<br>
DOI: 10.6084/m9.figshare.11662773
title: Real-time deformability cytometry data of primary human skeletal stem cells and the human osteosarcoma cell line MG-63

description: <b>Real-time deformability data of primary human skeletal stem cells and the human osteosarcoma cell line MG-63</b><br><br>The MG-63 cell line is used as a model system for human skeletal stem cells (SSC). See references [1] and [2] for more information. The file names follow the pattern <i>"[sample]_[flow rate/reservoir]_[repetition]_[date].rtdc"</i>, i.e. the file "SSC_32uls_rep1_20150611.rtdc" contains human skeletal stem cell data measured at a flow rate of 32µl/s - it is the first of two repetitions.<br><br><br>This is a subset of the data used by Xavier et al. [1] to quantify the stiffness of MG-63 and SSC cells. Herbig et al. [2] used the 16µl/s data in section IIID to illustrate linear mixed model analysis.<br><br><br><b>References<br></b>[1] M. Xavier et al., Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry, Integrative Biology, 2016, doi:10.1039/C5IB00304K<br><br>[2] M. Herbig et al., Statistics for real-time deformability cytometry: Clustering, dimensionality reduction, and significance testing, Biomicrofluidics, 2018. doi:10.1063/1.5027197<br><br>
DOI: 10.17028/rd.lboro.11662764
title: Supplementary Information Files for 'Integrating habitat- and species-based perspectives for wetland conservation in lowland agricultural landscapes'

description: Three figures and a pdf document of supplementary information for the article 'Integrating habitat- and species-based perspectives for wetland conservation in lowland agricultural landscapes'<br>Abstract:Wetlands are among the most endangered ecosystems worldwide with multiple direct and indirect stressors, especially in human-altered areas like intensive agricultural landscapes. Conservation management and efforts often focus on species diversity and charismatic taxa, but scarcely consider habitats. By focusing on a complex formed by 107 permanent wetlands at 18 Natura 2000 sites in the Emilia-Romagna region (northern Italy), the patterns of habitats of conservation concern were investigated and the concordance with threatened species patterns was analysed. Wetlands were characterised in terms of morphology, connectivity, land use and management as drivers of assemblage and richness patterns of habitats. Our results showed a strong concordance between the distribution and richness patterns of both habitats and threatened taxa (birds, mammals, amphibians, reptiles, fish, invertebrates, and plants). Thus, habitats seem an effective proxy of species patterns. The variables related with perimeter, environmental heterogeneity and presence of water bodies were the most important ones associated with habitat richness patterns. The presence of aquatic systems (measured as the percentage of wetland area occupied by an aquatic surface) and their position in the hydrographic network were associated mostly with habitats distribution. Low richness wetlands (in habitat terms) were not complementary as no new habitat types were supported. The results stressed the relevance of wetlands with wide water body perimeters composed of diverse systems as being key for biodiversity conservation in a simplified agricultural matrix. Integrating habitat- and species-based perspectives seems a promising field and may provide a rapid assessment tool to acquire effective information for wetlands conservation and assessment.<br>
DOI: 10.17028/rd.lboro.11662764.v1
title: Supplementary Information Files for 'Integrating habitat- and species-based perspectives for wetland conservation in lowland agricultural landscapes'

description: Three figures and a pdf document of supplementary information for the article 'Integrating habitat- and species-based perspectives for wetland conservation in lowland agricultural landscapes'<br>Abstract:Wetlands are among the most endangered ecosystems worldwide with multiple direct and indirect stressors, especially in human-altered areas like intensive agricultural landscapes. Conservation management and efforts often focus on species diversity and charismatic taxa, but scarcely consider habitats. By focusing on a complex formed by 107 permanent wetlands at 18 Natura 2000 sites in the Emilia-Romagna region (northern Italy), the patterns of habitats of conservation concern were investigated and the concordance with threatened species patterns was analysed. Wetlands were characterised in terms of morphology, connectivity, land use and management as drivers of assemblage and richness patterns of habitats. Our results showed a strong concordance between the distribution and richness patterns of both habitats and threatened taxa (birds, mammals, amphibians, reptiles, fish, invertebrates, and plants). Thus, habitats seem an effective proxy of species patterns. The variables related with perimeter, environmental heterogeneity and presence of water bodies were the most important ones associated with habitat richness patterns. The presence of aquatic systems (measured as the percentage of wetland area occupied by an aquatic surface) and their position in the hydrographic network were associated mostly with habitats distribution. Low richness wetlands (in habitat terms) were not complementary as no new habitat types were supported. The results stressed the relevance of wetlands with wide water body perimeters composed of diverse systems as being key for biodiversity conservation in a simplified agricultural matrix. Integrating habitat- and species-based perspectives seems a promising field and may provide a rapid assessment tool to acquire effective information for wetlands conservation and assessment.<br>
DOI: 10.6084/m9.figshare.11662773.v2
title: Real-time deformability cytometry data of primary human skeletal stem cells and the human osteosarcoma cell line MG-63

description: <b>Real-time deformability data of primary human skeletal stem cells and the human osteosarcoma cell line MG-63</b><br><br>The MG-63 cell line is used as a model system for human skeletal stem cells (SSC). See references [1] and [2] for more information. The file names follow the pattern <i>"[sample]_[flow rate/reservoir]_[repetition]_[date].rtdc"</i>, i.e. the file "SSC_32uls_rep1_20150611.rtdc" contains human skeletal stem cell data measured at a flow rate of 32µl/s - it is the first of two repetitions.<br><br><br>This is a subset of the data used by Xavier et al. [1] to quantify the stiffness of MG-63 and SSC cells. Herbig et al. [2] used the 16µl/s data in section IIID to illustrate linear mixed model analysis.<br><br><br><b>References<br></b>[1] M. Xavier et al., Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry, Integrative Biology, 2016, doi:10.1039/C5IB00304K<br><br>[2] M. Herbig et al., Statistics for real-time deformability cytometry: Clustering, dimensionality reduction, and significance testing, Biomicrofluidics, 2018. doi:10.1063/1.5027197<br><br>
DOI: 10.6084/m9.figshare.11662773.v1
title: Real-time deformability data of primary human skeletal stem cells and the human osteosarcoma cell line MG-63

description: <b>Real-time deformability data of primary human skeletal stem cells and the human osteosarcoma cell line MG-63</b><br><br>The MG-63 cell line is used as a model system for human skeletal stem cells (SSC). See references [1] and [2] for more information. The file names follow the pattern <i>"[sample]_[flow rate/reservoir]_[repetition]_[date].rtdc"</i>, i.e. the file "SSC_32uls_rep1_20150611.rtdc" contains human skeletal stem cell data measured at a flow rate of 32µl/s - it is the first of two repetitions.<br><br><br>This is a subset of the data used by Xavier et al. [1] to quantify the stiffness of MG-63 and SSC cells. Herbig et al. [2] used the 16µl/s data in section IIID to illustrate linear mixed model analysis.<br><br><br><b>References<br></b>[1] M. Xavier et al., Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry, Integrative Biology, 2016, doi:10.1039/C5IB00304K<br><br>[2] M. Herbig et al., Statistics for real-time deformability cytometry: Clustering, dimensionality reduction, and significance testing, Biomicrofluidics, 2018. doi:10.1063/1.5027197<br><br>
DOI: 10.6084/m9.figshare.11662725
title: My R project

description: This is my R project file.
DOI: 10.6084/m9.figshare.11662488
title: metafeatures.json

description: A learning curve dataset on OpenML data providing many statistics such as loss, accuracy, configuration, global and loca gradient statistics.<br>
DOI: 10.6084/m9.figshare.11662428
title: data_2k.zip

description: A learning curve dataset on OpenML data providing many statistics such as loss, accuracy, configuration, global and loca gradient statistics.<br>
DOI: 10.6084/m9.figshare.11662422
title: data_2k_lw.zip

description: A learning curve dataset on OpenML data providing many statistics such as loss, accuracy, configuration, global and loca gradient statistics.<br>
DOI: 10.6084/m9.figshare.11662368
title: Data and supplementary information for "Meteorological data for Nagata, Yakushima Island, Japan, during 2005–2014"

description: Data and supplementary information for "Meteorological data for Nagata, Yakushima Island, Japan, during 2005–2014". See <b>README.txt</b> for the details.
DOI: 10.6084/m9.figshare.11662347
title: Proteome database of Bacillus thuringiensis

description: <i>Bacillus thuringiensis </i>is a common soil-dwelling Gram-positive bacterium that sporulates. A pathogen for some insects due to the formation of crystal proteins known as δ-endotoxin, the bacterium has been a model organism for investigating natural pesticides. Besides soils, the bacterium also naturally inhabits a variety of surfaces such as those of different plants, in the gut of insects as well as in the aquatic environment. This work provides fundamental proteomic information about <i>B. thuringiensis</i> that could serve a variety of basic microbiological and biotechnological studies. Specifically, the UniProt proteome file of the organism was parsed by an in-house MATLAB proteome analysis software that results in the construction of a proteome database comprising protein name, amino acid sequence, number of residues, molecular weight and nucleotide sequence of proteins. Such information is critical for guiding many aspects of modern molecular cloning and protein analysis workflows pertinent to deciphering the molecular mechanisms that underlie the formation of crystal proteins as well as the biopesticidal effect of this bacterium. <br><br>
DOI: 10.6084/m9.figshare.11662347.v1
title: Proteome database of Bacillus thuringiensis

description: <i>Bacillus thuringiensis </i>is a common soil-dwelling Gram-positive bacterium that sporulates. A pathogen for some insects due to the formation of crystal proteins known as δ-endotoxin, the bacterium has been a model organism for investigating natural pesticides. Besides soils, the bacterium also naturally inhabits a variety of surfaces such as those of different plants, in the gut of insects as well as in the aquatic environment. This work provides fundamental proteomic information about <i>B. thuringiensis</i> that could serve a variety of basic microbiological and biotechnological studies. Specifically, the UniProt proteome file of the organism was parsed by an in-house MATLAB proteome analysis software that results in the construction of a proteome database comprising protein name, amino acid sequence, number of residues, molecular weight and nucleotide sequence of proteins. Such information is critical for guiding many aspects of modern molecular cloning and protein analysis workflows pertinent to deciphering the molecular mechanisms that underlie the formation of crystal proteins as well as the biopesticidal effect of this bacterium. <br><br>
DOI: 10.6084/m9.figshare.11662212
title: neo4j_Chembl_DrugBank.db.tar.gz

description: Data source for CompoundDB4j
DOI: 10.6084/m9.figshare.11662173
title: MOESM9 of Benchmarking principal component analysis for large-scale single-cell RNA-sequencing

description: Additional file 9 Pair plots of all the pCA (Pancreas) implementations.
DOI: 10.6084/m9.figshare.11662212.v1
title: neo4j_Chembl_DrugBank.db.tar.gz

description: Data source for CompoundDB4j
DOI: 10.6084/m9.figshare.11662170
title: MOESM8 of Benchmarking principal component analysis for large-scale single-cell RNA-sequencing

description: Additional file 8 Pair plots of all the pCA (PBMCs) implementations.