cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1279394.v259
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint from the early trans-species <i>O</i>-linked glycosylation of proteins and subsequent depletion of the volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might result in the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and the pronounced occurrence of anti-Tn in the plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and not affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1266451.v8
title: Parp1 nucleosome binding correlation study datasets

description: All RData files used in the fmdatabreastcaparp1 package and the PARP1 correlation analysis package fmcorrelationbreastcaparp1
DOI: 10.6084/m9.figshare.1266451.v7
title: FM Parp1 Correlation Data

description: All RData files used in the fmdatabreastcaparp1 package and the PARP1 correlation analysis package fmcorrelationbreastcaparp1
DOI: 10.6084/m9.figshare.1266476.v6
title: Informe de autoevaluación de actividades docentes. Jorge Hernán Ramírez. Universidad del Valle. Feb 15, 2014 a Dic 10, 2014.

description: Informe de autoevaluación Universidad del Valle.
DOI: 10.6084/m9.figshare.1266476.v8
title: Informe de autoevaluación de actividades docentes. Jorge Hernán Ramírez. Universidad del Valle. Feb 15, 2014 a Dic 10, 2014.

description: Informe de autoevaluación Universidad del Valle. Ramirez, Jorge H (2014): Mental disease stigma and academic bullying- criminal methods to silence medical and scientific debate. fig<strong>share</strong>.
DOI: 10.6084/m9.figshare.1279394.v260
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint from the early trans-species <i>O</i>-linked glycosylation of proteins and subsequent depletion of the volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might result in the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and the pronounced occurrence of anti-Tn in the plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and not affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1266476.v7
title: Informe de autoevaluación de actividades docentes. Jorge Hernán Ramírez. Universidad del Valle. Feb 15, 2014 a Dic 10, 2014.

description: Informe de autoevaluación Universidad del Valle.
DOI: 10.6084/m9.figshare.1279394.v261
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when expressed in any non-developmental tissue. Although ovariectomy and castration result in uncontrolled and/or enhanced humoral and cellular immunity involving increased weights of the spleen and thymus with pronounced B and T cell production, the development of mercaptoethanol-sensitive, complement-binding, non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This non-immune murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from the cross-reactive adaptive anti-A antibody, was strongly downregulated or did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint in the course of the early trans-species <i>O</i>-linked glycosylation of proteins and subsequent depletion of volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might result in the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and pronounced occurrence of anti-Tn in plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1279394.v262
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a mammalian immunoglobulin M (IgM) molecule was documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. While ovariectomy and castration result in uncontrolled immunity with pronounced B and T cell production, the non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from adaptive anti-A antibody did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint in the course of the early trans-species <i>O</i>-linked glycosylation of proteins and subsequent depletion of volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might result in the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure and quality of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and pronounced occurrence of anti-Tn in plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1279394.v263
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a mammalian immunoglobulin M (IgM) molecule was documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. While ovariectomy and castration result in uncontrolled immunity with pronounced B and T cell production, the non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from adaptive anti-A antibody did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint in the course of the early trans-species <i>O</i>-linked glycosylation of proteins and subsequent depletion of volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might result in the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure and quality of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and pronounced occurrence of anti-Tn in plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1266425
title: Data Preservation and Cyberinfrastructure

description: AGU F14 Poster on data preservation efforts related to legacy physical object collections at a state geological survey
DOI: 10.6084/m9.figshare.1279394.v264
title: Early ovariectomy reveals the germline encoding of the “natural” mammalian anti-A-reactive IgM reflecting developmental malignancy.

description: The germline encoding of a mammalian immunoglobulin M (IgM) molecule was documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. While ovariectomy and castration result in uncontrolled immunity with pronounced B and T cell production, the non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from adaptive anti-A antibody did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint during the early trans-species <i>O</i>-linked glycosylations of proteins in connection with subsequent or simultaneous depletion of volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might involve the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure and quality of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and pronounced occurrence of anti-Tn in plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1266424
title: Content Model Use and Development to Redeem Thin Scetion Records

description: Abstract: The National Geothermal Data System (NGDS) is a catalog of documents and datasets that provide information about geothermal resources located primarily within the United States. The goal of NGDS is to make large quantities of geothermal-relevant geoscience data available to the public by creating a national, sustainable, distributed, and interoperable network of data providers. The Geological Survey of Alabama (GSA) has been a data provider in the initial phase of NGDS. One method by which NGDS facilitates interoperability is through the use of content models. Content models provide a schema (structure) for submitted data. Schemas dictate where and how data should be entered. Content models use templates that simplify data formatting to expedite use by data providers. These methodologies implemented by NGDS can extend beyond geothermal data to all geoscience data. The GSA, using the NGDS physical samples content model, has tested and refined a content model for thin sections and thin section photos. Countless thin sections have been taken from oil and gas well cores housed at the GSA, and many of those thin sections have related photomicrographs. Record keeping for these thin sections has been scattered at best, and it is critical to capture their metadata while the content creators are still available. A next step will be to register the GSA’s thin sections with SESAR (System for Earth Sample Registration) and assign an IGSN (International Geo Sample Number) to each thin section. Additionally, the thin section records will be linked to the GSA’s online record database. When complete, the GSA’s thin sections will be more readily discoverable and have greater interoperability. Moving forward, the GSA is implementing use of NGDS-like content models and registration with SESAR and IGSN to improve collection maintenance and management of additional physical samples.
DOI: 10.6084/m9.figshare.1266425.v1
title: Data Preservation and Cyberinfrastructure

description: AGU F14 Poster on data preservation efforts related to legacy physical object collections at a state geological survey
DOI: 10.6084/m9.figshare.1266424.v1
title: Content Model Use and Development to Redeem Thin Scetion Records

description: Abstract: The National Geothermal Data System (NGDS) is a catalog of documents and datasets that provide information about geothermal resources located primarily within the United States. The goal of NGDS is to make large quantities of geothermal-relevant geoscience data available to the public by creating a national, sustainable, distributed, and interoperable network of data providers. The Geological Survey of Alabama (GSA) has been a data provider in the initial phase of NGDS. One method by which NGDS facilitates interoperability is through the use of content models. Content models provide a schema (structure) for submitted data. Schemas dictate where and how data should be entered. Content models use templates that simplify data formatting to expedite use by data providers. These methodologies implemented by NGDS can extend beyond geothermal data to all geoscience data. The GSA, using the NGDS physical samples content model, has tested and refined a content model for thin sections and thin section photos. Countless thin sections have been taken from oil and gas well cores housed at the GSA, and many of those thin sections have related photomicrographs. Record keeping for these thin sections has been scattered at best, and it is critical to capture their metadata while the content creators are still available. A next step will be to register the GSA’s thin sections with SESAR (System for Earth Sample Registration) and assign an IGSN (International Geo Sample Number) to each thin section. Additionally, the thin section records will be linked to the GSA’s online record database. When complete, the GSA’s thin sections will be more readily discoverable and have greater interoperability. Moving forward, the GSA is implementing use of NGDS-like content models and registration with SESAR and IGSN to improve collection maintenance and management of additional physical samples.
DOI: 10.6084/m9.figshare.1279394.v265
title: Germline encoded anti-A-reactive IgM arising from growth-dependent and aberrant O-GalNAc glycosylations*

description: The germline encoding of a mammalian immunoglobulin M (IgM) molecule was documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. While ovariectomy and castration result in uncontrolled immunity with pronounced B and T cell production, the non-immune anti-A reactivity in murine plasma was not enhanced after an ovariectomy that was performed in C57BL/10 mice prior to the onset of puberty. This murine anti-A, which is complementary to the GalNAc glycan of syngeneic ovarian glycolipids and distinct from adaptive anti-A antibody did not appear in plasma of animals ovariectomized at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint during the early trans-species <i>O</i>-linked glycosylations of proteins in connection with subsequent or simultaneous depletion of volatilely expressed “immature” <i>O</i>-GalNAc transferase activities, which might involve the generation and release of glycan-depleted proteins that by binding sites and reactivity reflect the structure and quality of the disappeared glycan. Consequently, these volatilely expressed non-somatic <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and pronounced occurrence of anti-Tn in plasma of the human histo (blood) group O, in which the A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the anti-Tn levels.
DOI: 10.6084/m9.figshare.1279394.v266
title: Germline encoded anti-A-reactive IgM arising from growth-dependent and aber-rant O-GalNAc glycosylations*

description: The germline encoding of a mammalian immunoglobulin M (IgM) molecule was experimentally documented for the first time in C57BL/10 mice subjected to an ovariectomy prior to the onset of puberty. The target of this innate antibody is a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. This murine anti-A, which is complementary to the GalNAc glycan expressed by syngeneic ovarian glycolipids and distinct from cross-reactive adaptive anti-A antibody, did not appear in the plasma of animals subjected to ovariectomy at the age of 20 days. In mouse and man, this molecule most likely gets its complementary footprint from the early growth-dependent, trans-species <i>O</i>-GalNAc glycosylations of proteins in connection with the subsequent transferase depletions, which result in the formation and release of glycan-depleted proteins that through specific binding sites and reactivity might establish this process and reveal the structure and quality of the volatilely expressed, “lost” glycans. Consequently, these <i>O</i>-GalNAc-glycosylations of proteins, involving serine/threonine residues, are either identical or metabolically related with those of the mucin-type, “aberrant” monosaccharide GalNAcα1-<i>O</i>-Ser/Thr-R or Tn antigen and explain the anti-Tn cross-reactivity of anti-A specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in the plasma of human histo (blood) group O. In fact, in the blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur and affect the reactivity of the anti-Tn antibody, which may occur in appearance as a growth regulator and depending on its level, initiates the process of growth inhibition through substrate competition with subsequent trans-species <i>O</i>-GalNAc-glycosylations.
DOI: 10.6084/m9.figshare.1266375
title: Visualising gait symmetry/asymmetry from acceleration data

description: Accelerometry-based quantification of gait symmetry/asymmetry is a promising approach for objectively evaluating gait dysfunctions. An important step in the application of this method in clinical settings is to develop reliable gait asymmetry measures and tools for visualising them to create easy-to-understand presentations for both clinicians and patients. This paper describes a new self-adaptive algorithm for estimating motion trajectory from acceleration data and visualising the degree of its asymmetry in 3D space. Two new parameters are introduced to capture asymmetric walking patterns based on the assessment of 3D autocorrelation and biphasicity of the motion trajectory. The performance of our algorithm is confirmed by analysing gait data collected from 245 healthy subjects. The proposed method may be clinically useful in tracking the process of recovering from pathology or injury after rehabilitation.