cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.24400/527896/a01-2022.002
title: FSLE - Finite-Size Lyapunov Exponents and Orientations of the associated eigenvectors
title: Version 2024

description: The maps of Backward-in-time, Finite-Size Lyapunov Exponents (FSLEs) and Orientations of associated eigenvectors are computed over 30-year altimetry period and over global ocean in Delayed-Time and in Near-Real-Time. As a snapshot, each map represents the sea state for a given day. The Exponents and Orientations are distributed on a 1/25deg grid on a global coverage. In Delayed-Time, the maps are calculated every days since 1994/04/01. They are updated every year. In Near-Real-Time, the maps are delivered every day, with 20 days of delay.
DOI: 10.15468/dl.jgy8ru
title: Occurrence Download

description: A dataset containing 87 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "TaxonKey is Datnioides microlepis"
 ]
}

 The dataset includes 87 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009278-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7ubetz
title: Occurrence Download

description: A dataset containing 2179 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cypriniformes",
 "OccurrenceStatus is Present",
 "Geometry MULTIPOLYGON (((16.1257 -22.0882, 15.8234 -22.4662, 15.606 -22.8993, 15.4784 -23.4046, 15.4933 -24.0715, 20.509 -24.0715, 20.509 -28.5786, 20.509 -32.9007, 25.5395 -32.9007, 25.5395 -28.5786, 25.5395 -24.0715, 25.5395 -23.2724, 25.1306 -24.0715, 24.9333 -24.4571, 23.8962 -24.2467, 22.8065 -24.295, 22.3719 -24.7207, 22.2323 -25.547, 22.0387 -25.7188, 21.7833 -25.7784, 21.5388 -25.7113, 21.3553 -25.5415, 20.7576 -24.3688, 20.529 -24.0715, 20.509 -24.0455, 20.0952 -23.5072, 19.9968 -23.017, 19.7843 -22.5405, 19.1988 -21.8785, 18.5972 -21.5447, 17.8859 -21.3993, 17.1626 -21.4805, 16.5332 -21.7596, 16.1257 -22.0882)), ((20.2855 -34.7533, 20.509 -34.5676, 20.509 -32.9007, 17.7723 -32.9007, 17.8156 -33.0786, 18.3471 -33.7176, 18.3748 -33.8287, 18.2181 -34.0492, 18.3197 -34.3408, 18.4452 -34.429, 18.5435 -34.4213, 18.5872 -34.3667, 18.5363 -34.167, 18.7345 -34.1508, 18.7216 -34.3637, 18.7808 -34.4521, 19.0289 -34.4206, 19.0831 -34.4835, 19.2655 -34.5017, 19.2032 -34.6157, 19.2394 -34.6926, 19.375 -34.6963, 19.6091 -34.8524, 19.8251 -34.8396, 19.9798 -34.9064, 20.1081 -34.8731, 20.1517 -34.7847, 20.2855 -34.7533)), ((35.6007 -23.165, 35.628 -23.023, 35.6007 -22.9702, 35.6007 -23.165)), ((35.6007 -24.0157, 35.6306 -23.844, 35.6007 -23.8125, 35.6007 -24.0157)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 {
 "not" : {
 "Issue" : [
 "is one of (Recorded date invalid, Recorded date mismatch, Recorded date unlikely, Modified date invalid)"
 ]
 }
 }
 ]
}

 The dataset includes 2179 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009280-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17185637
title: Integrated Machine Learning Approaches to Explore the Role of Glycosylation-Related Genes in Idiopathic Pulmonary Fibrosis
DOI: 10.5281/zenodo.17185638
title: Integrated Machine Learning Approaches to Explore the Role of Glycosylation-Related Genes in Idiopathic Pulmonary Fibrosis
DOI: 10.15468/dl.tmq8es
title: Occurrence Download

description: A dataset containing 6988 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Monitoreos trianuales de fauna y flora en el Valle del Cerrejón, La Guajira",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 6988 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009282-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ytcsdn
title: Occurrence Download

description: A dataset containing 31556 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cypriniformes",
 "OccurrenceStatus is Present",
 "Geometry MULTIPOLYGON (((25.5395 -23.2724, 25.5395 -24.0715, 25.5395 -28.5786, 25.5395 -32.9007, 20.509 -32.9007, 20.509 -34.5676, 20.524 -34.555, 20.8859 -34.5419, 20.9606 -34.4398, 21.2995 -34.5131, 21.5296 -34.4338, 21.8696 -34.4439, 22.0323 -34.2835, 22.221 -34.2428, 22.2566 -34.1304, 22.5993 -34.0741, 22.9652 -34.1674, 23.4069 -34.1858, 23.4955 -34.0792, 23.6056 -34.0563, 24.8471 -34.2877, 24.9447 -34.2397, 25.0214 -34.0501, 25.5395 -34.1098, 25.6468 -34.1222, 25.7787 -34.0734, 25.7098 -33.9109, 25.8639 -33.797, 26.4806 -33.8473, 27.1586 -33.5889, 28.2048 -32.9007, 28.5753 -32.6569, 29.4902 -31.7517, 30.0251 -31.3959, 30.5701 -30.7329, 30.6252 -30.6659, 31.4179 -29.4257, 31.8178 -29.0299, 32.064 -28.9416, 32.4847 -28.5786, 32.55 -28.5222, 33.0346 -26.8668, 32.9741 -26.7838, 33.0415 -26.059, 32.9304 -26.0011, 32.7994 -26.1281, 32.6834 -26.0015, 32.813 -25.8728, 32.8513 -25.7166, 33.3048 -25.3731, 35.1489 -24.6699, 35.5808 -24.13, 35.5909 -24.0715, 35.6007 -24.0157, 35.6007 -23.8125, 35.4969 -23.7035, 35.6007 -23.165, 35.6007 -22.9702, 35.227 -22.2482, 34.6862 -21.6944, 34.013 -21.3095, 33.5 -21.1593, 32.9675 -21.1092, 32.4352 -21.1612, 31.8862 -21.3285, 30.5701 -20.3186, 29.6496 -19.6123, 28.947 -19.4003, 28.1821 -19.4609, 27.6072 -19.7214, 27.1332 -20.158, 25.5395 -23.2724)), ((17.754 -32.8255, 17.7723 -32.9007, 20.509 -32.9007, 20.509 -28.5786, 20.509 -24.0715, 15.4933 -24.0715, 15.4945 -24.1257, 16.0509 -25.6631, 15.6372 -28.0032, 16.2782 -28.5786, 16.4358 -28.7202, 16.726 -29.1235, 17.1957 -30.3752, 17.6655 -31.1743, 18.1322 -31.7679, 18.2495 -32.2638, 18.2339 -32.5266, 18.1411 -32.657, 18.1007 -32.7021, 18.0224 -32.6366, 17.8923 -32.6419, 17.754 -32.8255)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 {
 "not" : {
 "Issue" : [
 "is one of (Recorded date invalid, Recorded date mismatch, Recorded date unlikely, Modified date invalid)"
 ]
 }
 }
 ]
}

 The dataset includes 31556 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009279-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.decq5v
title: Occurrence Download

description: A dataset containing 2179 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cypriniformes",
 "OccurrenceStatus is Present",
 "Geometry MULTIPOLYGON (((16.1257 -22.0882, 15.8234 -22.4662, 15.606 -22.8993, 15.4784 -23.4046, 15.4933 -24.0715, 20.509 -24.0715, 20.509 -28.5786, 20.509 -32.9007, 25.5395 -32.9007, 25.5395 -28.5786, 25.5395 -24.0715, 25.5395 -23.2724, 25.1306 -24.0715, 24.9333 -24.4571, 23.8962 -24.2467, 22.8065 -24.295, 22.3719 -24.7207, 22.2323 -25.547, 22.0387 -25.7188, 21.7833 -25.7784, 21.5388 -25.7113, 21.3553 -25.5415, 20.7576 -24.3688, 20.529 -24.0715, 20.509 -24.0455, 20.0952 -23.5072, 19.9968 -23.017, 19.7843 -22.5405, 19.1988 -21.8785, 18.5972 -21.5447, 17.8859 -21.3993, 17.1626 -21.4805, 16.5332 -21.7596, 16.1257 -22.0882)), ((20.2855 -34.7533, 20.509 -34.5676, 20.509 -32.9007, 17.7723 -32.9007, 17.8156 -33.0786, 18.3471 -33.7176, 18.3748 -33.8287, 18.2181 -34.0492, 18.3197 -34.3408, 18.4452 -34.429, 18.5435 -34.4213, 18.5872 -34.3667, 18.5363 -34.167, 18.7345 -34.1508, 18.7216 -34.3637, 18.7808 -34.4521, 19.0289 -34.4206, 19.0831 -34.4835, 19.2655 -34.5017, 19.2032 -34.6157, 19.2394 -34.6926, 19.375 -34.6963, 19.6091 -34.8524, 19.8251 -34.8396, 19.9798 -34.9064, 20.1081 -34.8731, 20.1517 -34.7847, 20.2855 -34.7533)), ((35.6007 -23.165, 35.628 -23.023, 35.6007 -22.9702, 35.6007 -23.165)), ((35.6007 -24.0157, 35.6306 -23.844, 35.6007 -23.8125, 35.6007 -24.0157)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 {
 "not" : {
 "Issue" : [
 "is one of (Recorded date invalid, Recorded date mismatch, Recorded date unlikely, Modified date invalid)"
 ]
 }
 }
 ]
}

 The dataset includes 2179 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009281-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f28nkg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tarenaya hassleriana",
 "Country is Eswatini",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009283-250920141307145/datasets/export for details.
DOI: 10.15468/dl.rsxfk2
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tarenaya hassleriana",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 12 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009284-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dx3fvf
title: Occurrence Download

description: A dataset containing 126 records in GBIF matching the query:
SELECT
 kingdom,
 kingdomkey,
 phylum,
 phylumkey,
 class,
 classkey,
 "order",
 orderkey,
 family,
 familykey,
 genus,
 genuskey,
 species,
 specieskey,
 "year",
 IF(ISNULL(kingdomkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY kingdomkey, "year")) kingdomcount,
 IF(ISNULL(phylumkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY phylumkey, "year")) phylumcount,
 IF(ISNULL(classkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY classkey, "year")) classcount,
 IF(ISNULL(orderkey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY orderkey, "year")) ordercount,
 IF(ISNULL(familykey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY familykey, "year")) familycount,
 IF(ISNULL(genuskey), NULL, SUM(COUNT(*)) OVER (
 PARTITION BY genuskey, "year")) genuscount,
 COUNT(*) occurrences,
 MIN(GBIF_TEMPORALUNCERTAINTY(eventdate, eventtime)) mintemporaluncertainty,
 MIN(COALESCE(coordinateuncertaintyinmeters, 1000)) mincoordinateuncertaintyinmeters
FROM
 occurrence
WHERE
 occurrence.occurrencestatus = 'PRESENT'
 AND (CAST(occurrence.taxonkey AS INTEGER) = 3894676 OR CAST(occurrence.acceptedtaxonkey AS INTEGER) = 3894676 OR CAST(occurrence.kingdomkey AS INTEGER) = 3894676 OR CAST(occurrence.phylumkey AS INTEGER) = 3894676 OR CAST(occurrence.classkey AS INTEGER) = 3894676 OR CAST(occurrence.orderkey AS INTEGER) = 3894676 OR CAST(occurrence.familykey AS INTEGER) = 3894676 OR CAST(occurrence.genuskey AS INTEGER) = 3894676 OR CAST(occurrence.specieskey AS INTEGER) = 3894676)
 AND (occurrence.specieskey IS NOT NULL AND occurrence."year" IS NOT NULL)
GROUP BY
 occurrence.kingdom,
 occurrence.kingdomkey,
 occurrence.phylum,
 occurrence.phylumkey,
 occurrence.class,
 occurrence.classkey,
 occurrence."order",
 occurrence.orderkey,
 occurrence.family,
 occurrence.familykey,
 occurrence.genus,
 occurrence.genuskey,
 occurrence.species,
 occurrence.specieskey,
 occurrence."year"

 The dataset's 126 records were derived from 94 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009251-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kmmakq
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tarenaya hassleriana",
 "Country is South Africa",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009289-250920141307145/datasets/export for details.
DOI: 10.15468/dl.uvgwtq
title: Occurrence Download

description: A dataset containing 6988 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Monitoreos trianuales de fauna y flora en el Valle del Cerrejón, La Guajira",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 6988 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009287-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jn2nfb
title: Occurrence Download

description: A dataset containing 20160 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Sphagnum magellanicum"
 ]
}

 The dataset includes 20160 records from 277 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009288-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yvm7v3
title: Occurrence Download

description: A dataset containing 13924 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "OccurrenceStatus is Present",
 "StateProvince is Montana",
 "TaxonKey is Apidae"
 ]
}

 The dataset includes 13924 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009292-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18727/archive/102
title: Structure, Excitation, and Dynamics of the Inner Galactic Interstellar Medium (SEDIGISM)

description: The SEDIGISM (Structure, Excitation and Dynamics of the Inner Galactic Interstellar Medium) survey is an APEX 12-m telescope programme designed to map molecular gas in the inner Milky Way. The survey covers about 84 deg² of the southern Galactic plane, with continuous coverage from −60° ≤ l ≤ +17° at |b| ≤ 0.5°, and an additional 2 deg² region between +29° and +31° (W43) for comparison with northern surveys. The latitude range is extended in selected regions, reaching |b| ≤ 1° towards the Central Molecular Zone, b ≤ +0.75° towards RCW 120, and b ≤ −0.75° towards the Nessie filament. The primary data products are 13CO(2–1) and C18O(2–1) spectral cubes, complemented by additional transitions including CH3OH, H2CO, HC3N, HNCO, SiO, SO2, and SO. The dataset comprises 78 FITS cubes, each covering about 2° × 1° with 1° overlap, sampled at 9.5” pixels, 30” angular resolution, and 0.25 km/s velocity resolution (0.5 km/s for ancillary lines). The typical sensitivity is 0.8–1.0 K per channel (Tmb scale). The release includes fully calibrated spectral cubes and corresponding white-light integrated intensity maps.
description: This is a dynamic dataset; it is growing as new data is added. the DOI refers to the newest available dataset.
DOI: 10.15468/dl.m5fpdj
title: Occurrence Download

description: A dataset containing 86 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tarenaya hassleriana",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 86 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009293-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r92ssf
title: Occurrence Download

description: A dataset containing 220 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Lichenized Fungi Collection in Tay Nguyen University"
 ]
}

 The dataset includes 220 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009294-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fk9x7a
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tarenaya hassleriana",
 "Country is Viet Nam",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009296-250920141307145/datasets/export for details.
DOI: 10.15468/dl.xk3bq9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tarenaya hassleriana",
 "Country is Venezuela (Bolivarian Republic of)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009295-250920141307145/datasets/export for details.
DOI: 10.15468/dl.5uanm6
title: Occurrence Download

description: A dataset containing 1598806 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((35.851 -5.006, 38.834 -5.006, 38.834 -1.834, 35.851 -1.834, 35.851 -5.006))",
 "EventDate is greater than or equal to 1900-01-01",
 "EventDate is less than or equal to 2025-09-24"
 ]
}

 The dataset includes 1598806 records from 510 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009232-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fzby9c
title: Occurrence Download

description: A dataset containing 62 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Northern Cyprus 2009 (aggregated per 1-degree cell)"
 ]
}

 The dataset includes 62 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009298-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n2vqby
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Caylusea abyssinica",
 "Country is Belgium",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009299-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/13149205
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.5281/zenodo.17156571
title: Evaluation of LLM-based MT against Human Translators
DOI: 10.5281/zenodo.17156572
title: Evaluation of LLM-based MT against Human Translators
DOI: 10.15468/dl.zwmv3n
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Delosperma cooperi",
 "Country is Croatia",
 "HasCoordinate is true"
 ]
}

 The dataset includes 14 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009301-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30188398
title: Flavor and Bioactive Component Dynamics in Pueraria lobata Fermentation and the Potential Hypolipidemic Mechanism: An Integrated Approach Combining Intelligent Sensory Analysis, UHPLC-QTOF/MS, Network Pharmacology, Molecular Docking and Dynamics Simulation

description: This study systematically investigated the multidimensional effects of lactobacillus fermentation on Pueraria lobata (PL), and preliminarily explored its differential mechanisms of lipid-lowering through variations in fermentation processes. Results indicate that lactobacillus fermentation effectively preserves the contents of pharmacologically active components such as total flavonoids and total phenols in PL, while promoting the accumulation of total acids and maintaining its inherent antioxidant capacity. Flavor analysis revealed enhanced astringency and attenuated bitterness in fermented PL, accompanied by the formation of volatile flavor compounds such as β-pinene and butyric acid trans-2-hexenyl ester, collectively contributing to its unique flavor profile. Non-targeted metabolomics reveals that lactobacillus fermentation specifically drives the enrichment of low-abundance isoflavone aglycones such as daidzein and genistein, which exhibit higher bioactivity and bioavailability with potential for enhanced hypolipidemic activity. Network pharmacology combined with computational simulation identified 8 key enriched compounds, including genistein, which stably bound to 10 core targets (e.g., MMP9, ESR1) via hydrogen bonds/hydrophobic interactions, activating phosphoinositide 3-kinase/protein kinase B(PI3K-AKT) and estrogen signaling pathways to regulate lipid metabolism. This study elucidates the the enzymatic hydrolysis of puerarin glycosides to aglycones mediated by lactobacillus fermentation, constructes a multidimensional network of "components-targets-pathways-hyperlipidemia," and provides theoretical support for developing functional Pueraria-derived lipid-lowering products.
DOI: 10.6084/m9.figshare.30188398.v1
title: Flavor and Bioactive Component Dynamics in Pueraria lobata Fermentation and the Potential Hypolipidemic Mechanism: An Integrated Approach Combining Intelligent Sensory Analysis, UHPLC-QTOF/MS, Network Pharmacology, Molecular Docking and Dynamics Simulation

description: This study systematically investigated the multidimensional effects of lactobacillus fermentation on Pueraria lobata (PL), and preliminarily explored its differential mechanisms of lipid-lowering through variations in fermentation processes. Results indicate that lactobacillus fermentation effectively preserves the contents of pharmacologically active components such as total flavonoids and total phenols in PL, while promoting the accumulation of total acids and maintaining its inherent antioxidant capacity. Flavor analysis revealed enhanced astringency and attenuated bitterness in fermented PL, accompanied by the formation of volatile flavor compounds such as β-pinene and butyric acid trans-2-hexenyl ester, collectively contributing to its unique flavor profile. Non-targeted metabolomics reveals that lactobacillus fermentation specifically drives the enrichment of low-abundance isoflavone aglycones such as daidzein and genistein, which exhibit higher bioactivity and bioavailability with potential for enhanced hypolipidemic activity. Network pharmacology combined with computational simulation identified 8 key enriched compounds, including genistein, which stably bound to 10 core targets (e.g., MMP9, ESR1) via hydrogen bonds/hydrophobic interactions, activating phosphoinositide 3-kinase/protein kinase B(PI3K-AKT) and estrogen signaling pathways to regulate lipid metabolism. This study elucidates the the enzymatic hydrolysis of puerarin glycosides to aglycones mediated by lactobacillus fermentation, constructes a multidimensional network of "components-targets-pathways-hyperlipidemia," and provides theoretical support for developing functional Pueraria-derived lipid-lowering products.