cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19533025
title: Ecofriendly Spectrophotometric Methods for the Simultaneous Determination of Flupirtine Maleate and Thiocolchicoside: Evaluation of Greenness Profile

description: The present study represents four simple UV spectrophotometric methods that are accurate, precise, and ecofriendly for estimating flupirtine maleate and thiocolchicoside in pharmaceutical formulation. The four methods are the second order derivative of zero order spectra, the first derivative of ratio spectra, the extended ratio subtraction technique, and the absorption factor method. The proposed methods have linear calibration curves in the range of 14-26 to 2.80-5.2 µg mL<sup>-1</sup> for flupirtine maleate and thiocolchicoside, correspondingly. The proposed methods are evaluated toward synthetic mixtures of the drugs as mentioned earlier and then extended to commercial pharmaceutical formulations of the analytes of interest. The findings of the assay for determining the cited drugs in pharmaceutical tablets were statistically analysed with those of the published HPLC method, implying that no discernible difference exists between the suggested and published procedures. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. The methods have been validated according to ICH criteria and confirmed to be within acceptable limits.
DOI: 10.15151/esrf-es-686558386
title: BAG for the Structural Biology Groups in Madrid

description: This proposal is a collaborative effort of the Structural Biology Groups of Madrid with the objective to form a strong core of scientist devoted to this area of research in Spain. It is composed of 18 groups distributed in 4 Institutes.
DOI: 10.15151/esrf-es-705440176
title: The Netherlands BAG

description: The Netherlands BAG includes groups situated at five Dutch universities (Utrecht, Groningen, Amsterdam, Wageningen and Eindhoven) and at the Netherlands Cancer Institute in Amsterdam, with a total of twelve PIs. The structural biology research carried out in these groups is highly diverse, including prokaryotic and eukaryotic proteins with a strong focus on targets and processes of biomedical relevance. Central to many projects are protein receptors and their interactions with other proteins and with small molecule modulators. An additional major research area concerns structure-based protein engineering and design aiming at the characterization and engineering of new enzymes for green chemistry and new-to-nature reactions. Projects deal with membrane and soluble proteins, cell surface receptors, and protein-protein, protein-ribonucleotide, protein-drug and enzyme-ligand complexes.
DOI: 10.15151/esrf-es-705444849
title: BAG Montpellier

description: The BAG of Montpellier ...
DOI: 10.15151/esrf-es-686597007
title: Synchrotron Serial Crystallography (SSX) BAG

description: The aim of this BAG is the development of new methods, hardware and software for different applications in SSX. The new EBS machine is in the privileged position of exploiting flux density previously unmatched at synchrotron beamlines. This is likely to open a new paradigm in serial synchrotron crystallography, by enhancing the signal to noise of the diffraction data and reducing the minimum exposure time. The increase in photon flux density at the sample position will interest most of the MX beamlines and it is going to be particularly effective for microfocus beamline such as ID23-2 and ID30A3. We plan to further develop different SSX data collection methods in the attempt to profit of the characteristic of the new beam and to extend the implementation of automated procedures to simplify the access to SSX methods for the MX community.
DOI: 10.15151/esrf-es-755354239
title: X-ray nano imaging of complex materials

description: Multiple technique developments and sample tests are foreseen in this proposal.
DOI: 10.5283/epub.35087
title: Data archive of "Keep flexible - keep switching! The influence of forced task switching on voluntary task switching"
DOI: 10.14469/hpc/10338
title: Sulfolane, G = -705.690341

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/10339
title: PhBF2 in sulfolane, G = -456.159277 (sum = -1,161.849618)

description: Gaussian 16 (C01) calculation
DOI: 10.14469/hpc/10340
title: PhBF2-sulfolane in sulfolane, G = -1161.844527 ( = +0.34)

description: Gaussian 16 (C01) calculation
DOI: 10.6084/m9.figshare.13102050
title: Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil

description: Virgin coconut oil (VCO) is a functional food oil prepared from fresh coconut kernel either by hot-processed (HPVCO) or fermentation-processed (FPVCO). The FPVCO has been widely explored for its pharmacological efficacy; while HPVCO, which has traditional uses, is less explored. The present study compared the phenolic content and nephroprotective effect of both these oils in male Wistar rats. <i>In vitro</i> antioxidant activity was estimated in terms of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power and <i>ex vivo</i> lipid peroxidation inhibition. In <i>in vivo</i> models, the rats were pretreated orally with of FPVCO or HPVCO (doses 2 and 4 mL/kg) for seven days and nephrotoxicity was induced by the single intraperitoneal injection of cisplatin (10 mg/kg). The results indicated significantly higher polyphenol content in HPVCO (400.3 ± 5.8 µg/mL) than that of FPVCO (255.5 ± 5.8 µg/mL). Corroborating with the increased levels of polyphenols, the <i>in vitro</i> antioxidant potential was significantly higher in the HPVCO. Further, pretreatment with these VCO preparations protected the rats against the cisplatin-induced nephrotoxicity, with higher extent by HPVCO. The renal function markers like urea, creatinine and total bilirubin were significantly reduced (<i>p</i>
DOI: 10.6084/m9.figshare.13102050.v1
title: Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil

description: Virgin coconut oil (VCO) is a functional food oil prepared from fresh coconut kernel either by hot-processed (HPVCO) or fermentation-processed (FPVCO). The FPVCO has been widely explored for its pharmacological efficacy; while HPVCO, which has traditional uses, is less explored. The present study compared the phenolic content and nephroprotective effect of both these oils in male Wistar rats. <i>In vitro</i> antioxidant activity was estimated in terms of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power and <i>ex vivo</i> lipid peroxidation inhibition. In <i>in vivo</i> models, the rats were pretreated orally with of FPVCO or HPVCO (doses 2 and 4 mL/kg) for seven days and nephrotoxicity was induced by the single intraperitoneal injection of cisplatin (10 mg/kg). The results indicated significantly higher polyphenol content in HPVCO (400.3 ± 5.8 µg/mL) than that of FPVCO (255.5 ± 5.8 µg/mL). Corroborating with the increased levels of polyphenols, the <i>in vitro</i> antioxidant potential was significantly higher in the HPVCO. Further, pretreatment with these VCO preparations protected the rats against the cisplatin-induced nephrotoxicity, with higher extent by HPVCO. The renal function markers like urea, creatinine and total bilirubin were significantly reduced (<i>p</i>
DOI: 10.6084/m9.figshare.13116606
title: Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia

description: Myopia (nearsightedness) is a vision disorder with a blurring of far objects, affect millions worldwide. 7-methylxanthine (7-MX) is a molecule that is presently under clinical investigation for the treatment of myopia. In the present study, we have investigated sub-chronic and chronic toxicity of 7-MX in comparison to other clinically used methylxanthines i.e., caffeine and theobromine as per OECD guidelines 408 and 452. 7-MX was administered orally for 90 days at three different doses of 250, 500, and 1000 mg/kg for sub-chronic toxicity evaluation, and at a limit dose of 1000 mg/kg in 180 days chronic toxicity evaluation in rats. In sub-chronic treatment, 7-MX showed no mortality and signs for toxicity in any group, whereas 10% and 40% mortality with signs for toxicity were observed in caffeine and theobromine treated groups, respectively. A similar, safety profile was observed with 7-MX in 180 days of chronic toxicity study. Further, to confirm any morphological changes in organs; ultrasound and X-rays analysis were performed and no changes in the size of organs, cyst formation, fluid retention, or crystal formation was observed. Thus, the repeated dose study of 7-MX for 180 days may augment the possibility of using 7-MX clinically for the safe and effective treatment of myopia.
DOI: 10.6084/m9.figshare.13116606.v1
title: Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia

description: Myopia (nearsightedness) is a vision disorder with a blurring of far objects, affect millions worldwide. 7-methylxanthine (7-MX) is a molecule that is presently under clinical investigation for the treatment of myopia. In the present study, we have investigated sub-chronic and chronic toxicity of 7-MX in comparison to other clinically used methylxanthines i.e., caffeine and theobromine as per OECD guidelines 408 and 452. 7-MX was administered orally for 90 days at three different doses of 250, 500, and 1000 mg/kg for sub-chronic toxicity evaluation, and at a limit dose of 1000 mg/kg in 180 days chronic toxicity evaluation in rats. In sub-chronic treatment, 7-MX showed no mortality and signs for toxicity in any group, whereas 10% and 40% mortality with signs for toxicity were observed in caffeine and theobromine treated groups, respectively. A similar, safety profile was observed with 7-MX in 180 days of chronic toxicity study. Further, to confirm any morphological changes in organs; ultrasound and X-rays analysis were performed and no changes in the size of organs, cyst formation, fluid retention, or crystal formation was observed. Thus, the repeated dose study of 7-MX for 180 days may augment the possibility of using 7-MX clinically for the safe and effective treatment of myopia.
DOI: 10.5281/zenodo.4475671
title: Analysematrix von Stellenausschreibungen mit Forschungsdaten(management)-Schwerpunkt in Deutschland 2020.01.03-2020.11.22

description: Matrix mit strukturierter Auswertung von 162 Stellenanzeigen mit FDM-Bezug (Zeunert, Miriam, & Schneemann, Carsten. (2021). Stellenkorpus - Forschungsdaten(management) 2020.01.03-2020.11.22 (Version 1.0.0.) [Data set]. Zenodo. http://doi.org/10.5281/zenodo.4430688), nach administrativen, formalen und inhaltlichen Kriterien, Schwerpunkt bildet die Verzeichnung des Anforderungsprofils.
DOI: 10.5281/zenodo.4475670
title: Analysematrix von Stellenausschreibungen mit Forschungsdaten(management)-Schwerpunkt in Deutschland 2020.01.03-2020.11.22

description: Matrix mit strukturierter Auswertung von 162 Stellenanzeigen mit FDM-Bezug (Zeunert, Miriam, & Schneemann, Carsten. (2021). Stellenkorpus - Forschungsdaten(management) 2020.01.03-2020.11.22 (Version 1.0.0.) [Data set]. Zenodo. http://doi.org/10.5281/zenodo.4430688), nach administrativen, formalen und inhaltlichen Kriterien, Schwerpunkt bildet die Verzeichnung des Anforderungsprofils.
DOI: 10.6084/m9.figshare.19532953
title: Genome assembly of an Australian native grass species reveals a recent whole genome duplication and biased gene retention of genes involved in stress response

description: This is the fasta file of the <i>Bothriochloa decipiens </i>chromosomal level final genome assembly and the gff file of gene annotation. This was used in the study titled as "Genome assembly of an Australian native grass species reveals a recent whole genome duplication and biased gene retention of genes involved in stress response" which will be submitted to Molecular Ecology Resources journal.
DOI: 10.6084/m9.figshare.19533082.v1
title: Data on occurrence of perfluoroalkyl substances in influents and effluents collected from different wastewater treatment plants in Latvia

description: The data set contains occurrence data of 17 perfluoroalkyl substances (PFAS) (including 10 perfluorinated carboxylic acids and 7 perfluorinated sulfonic acids) in influent and effluent samples collected from 43 wastewater treatment plants (WWTPs) located in different cities in Latvia.
DOI: 10.6084/m9.figshare.19533229
title: Factors Affecting Teachers’ Social Media Use during Covid-19

description: The survey was adapted from prior studies. It was validated through PLS-SEM measurement model
DOI: 10.5281/zenodo.4252765
title: Urban wastewater virome by viral metagenomics and target enrichment sequencing

description: Metagenomic analysis of virus in raw sewage.
DOI: 10.5281/zenodo.4252764
title: Urban wastewater virome by viral metagenomics and target enrichment sequencing

description: Metagenomic analysis of virus in raw sewage.
DOI: 10.5281/zenodo.4161275
title: Unveiling viruses associated to gastroenteritis using metagenomics approach

description: Metagenomic analysis of viruses in feces.
DOI: 10.5281/zenodo.4161274
title: Unveiling viruses associated to gastroenteritis using metagenomics approach

description: Metagenomic analysis of viruses in feces.
DOI: 10.34740/kaggle/dsv/3420041
title: Contrastive Language Image Pretraining by openai
DOI: 10.5281/zenodo.6418258
title: A list of body and object concepts

description: The list includes 784 human body parts and object concepts. The concepts are based on the available concept sets in Concepticon (List et al. 2016, 2021) and were tagged as <em>human body part,</em> <em>animal</em>, <em>clothing</em>, <em>food</em>, <em>household</em> <em>items</em>, <em>instrument</em>, <em>landscape</em>, <em>plant</em>, <em>spatial</em> <em>relation</em>, <em>tool</em>, and <em>vehicle</em>.
DOI: 10.5281/zenodo.6365495
title: A list of body and object concepts

description: The list includes 784 human body parts and object concepts. The concepts are based on the available concept sets in Concepticon (List et al. 2016, 2021) and were tagged as <em>human body part,</em> <em>animal</em>, <em>clothing</em>, <em>food</em>, <em>household</em> <em>items</em>, <em>instrument</em>, <em>landscape</em>, <em>plant</em>, <em>spatial</em> <em>relation</em>, <em>tool</em>, and <em>vehicle</em>.
DOI: 10.5281/zenodo.6418665
title: LiBforSecUse Data Release - Impedance spectra of life cycle tests of commercial 18650 cells

description: The EMPIR project LiBforSecUse aimed to develop empirical measurement models to estimate the residual capacity of second-use Li-ion battery cells with impedance-based measurement and evaluation methods. The models have been established based on a series of life cycle tests of commercial 18650 (graphite/NMC) cells including regular impedance spectroscopy and capacity measurements. The measured data are made publicly available here. They can be downloaded to verify the models established within the project and they may be used for further investigations. However, the user is asked to pay tribute to the project and the researchers providing the data by citing this data source. A pdf file is added to give more detailed information on the data.
description: There have been issues downloading the pdf. Therefore, the file has been replaced. There is no contentual difference between V1 and V2
DOI: 10.5281/zenodo.6418171
title: LiBforSecUse Data Release - Impedance spectra of life cycle tests of commercial 18650 cells

description: The EMPIR project LiBforSecUse aimed to develop empirical measurement models to estimate the residual capacity of second-use Li-ion battery cells with impedance-based measurement and evaluation methods. The models have been established based on a series of life cycle tests of commercial 18650 (graphite/NMC) cells including regular impedance spectroscopy and capacity measurements. The measured data are made publicly available here. They can be downloaded to verify the models established within the project and they may be used for further investigations. However, the user is asked to pay tribute to the project and the researchers providing the data by citing this data source. A pdf file is added to give more detailed information on the data.
description: There have been issues downloading the pdf. Therefore, the file has been replaced. There is no contentual difference between V1 and V2
DOI: 10.6084/m9.figshare.19533343.v1
title: Guizhi Fuling pill attenuates liver fibrosis <i>in vitro</i> and <i>in vivo</i> via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways

description: Liver fibrosis resulting from chronic liver injuries (CLI) is a common health problem globally. Guizhi Fuling pill (GZFL), a modern preparation from traditional Chinese medicine, exhibited anti-dysmenorrhea, anti-inflammatory, and immune-regulative effects. However, the effect of GZFL on liver fibrosis remains unknown. In this research, LX-2 cells were stimulated with acetaldehyde for mimicking liver fibrosis progression <i>in vitro</i>. In addition, carbon tetrachloride (CCl<sub>4</sub>)-induced mouse model of liver fibrosis was established as well. The data revealed GZFL obviously suppressed the proliferation and triggered the apoptosis of acetaldehyde-stimulated LX-2 cells. In addition, GZFL prevented acetaldehyde-induced activation of LX-2 cells via downregulation of TGF-β1, p-Smad2, p-Smad3, CUGBP1, and upregulation of p-STAT1 and Smad7. Meanwhile, GZFL significantly alleviated CCl<sub>4</sub>‑induced liver fibrosis, as evidenced by the decrease of ALT and AST levels. Moreover, GZFL downregulated the expressions of TGF-β1, p-Smad2, p-Smad3, and CUGBP1 in CCl<sub>4</sub>-treated mice. Furthermore, GZFL remarkably elevated the levels of IFN-γ, p-STAT1, and Smad7 in CCl<sub>4</sub>-treated mice. To sum up, GZFL was able to inhibit liver fibrosis <i>in vitro</i> and <i>in vivo</i> through suppressing TGF-β1/Smad2/3-CUGBP1 signaling and activating IFN-γ/STAT1/Smad7 signaling. Thus, GZFL might have a potential to act as a therapeutic agent for anti-fibrotic therapy.
DOI: 10.6084/m9.figshare.19533343
title: Guizhi Fuling pill attenuates liver fibrosis <i>in vitro</i> and <i>in vivo</i> via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways

description: Liver fibrosis resulting from chronic liver injuries (CLI) is a common health problem globally. Guizhi Fuling pill (GZFL), a modern preparation from traditional Chinese medicine, exhibited anti-dysmenorrhea, anti-inflammatory, and immune-regulative effects. However, the effect of GZFL on liver fibrosis remains unknown. In this research, LX-2 cells were stimulated with acetaldehyde for mimicking liver fibrosis progression <i>in vitro</i>. In addition, carbon tetrachloride (CCl<sub>4</sub>)-induced mouse model of liver fibrosis was established as well. The data revealed GZFL obviously suppressed the proliferation and triggered the apoptosis of acetaldehyde-stimulated LX-2 cells. In addition, GZFL prevented acetaldehyde-induced activation of LX-2 cells via downregulation of TGF-β1, p-Smad2, p-Smad3, CUGBP1, and upregulation of p-STAT1 and Smad7. Meanwhile, GZFL significantly alleviated CCl<sub>4</sub>‑induced liver fibrosis, as evidenced by the decrease of ALT and AST levels. Moreover, GZFL downregulated the expressions of TGF-β1, p-Smad2, p-Smad3, and CUGBP1 in CCl<sub>4</sub>-treated mice. Furthermore, GZFL remarkably elevated the levels of IFN-γ, p-STAT1, and Smad7 in CCl<sub>4</sub>-treated mice. To sum up, GZFL was able to inhibit liver fibrosis <i>in vitro</i> and <i>in vivo</i> through suppressing TGF-β1/Smad2/3-CUGBP1 signaling and activating IFN-γ/STAT1/Smad7 signaling. Thus, GZFL might have a potential to act as a therapeutic agent for anti-fibrotic therapy.
DOI: 10.6084/m9.figshare.14545760
title: DNA barcoding approach to characterize microalgae isolated from freshwater systems in Ecuador

description: The use of suitable DNA barcodes and the generation of databases with reference sequences have been considered a promissory approach for the identification of Chlorophyta and Cyanophyta microalgae. In this study, we carried out a molecular characterization and identification of strains isolated from freshwater systems in Ecuador using a dual barcode method. The target sequences for Chlorophyta were 18S rDNA and <i>rbc</i>L genes, and 16S rDNA and 16S–23S rDNA intergenic spacer (ITS) for Cyanophyta. We reported these DNA barcodes for 20 different Molecular Operational Taxonomic Units (MOTUs) for Chlorophyta and 10 for Cyanophyta. Our results show that the 18S V4 hypervariable region (300 bp) is sufficient for differentiating between isolates, but <i>rbc</i>L is a determinant for genus identification in Scenedesmaceae and Chlorellaceae strains. In Cyanophyta, both barcodes enabled the genus-level assignment of 9 out of 10 MOTUs. These results highlight the necessity of a second barcode additional to small ribosomal subunit sequences to improve molecular identification. Furthermore, the present study significantly contributes to the body of Ecuadorian barcode sequences of microalgae that are currently documented, making them available for future comparative diversity studies.
DOI: 10.6084/m9.figshare.17138774
title: Exploring local morphological and molecular variation in parasitic species <i>Gaiadendron punctatum</i> (Loranthaceae) from Northwestern Andes of Colombia

description: <i>Gaiadendron punctatum</i> (Ruiz & Pav.) G. Don. exhibits a wide morphological variation and geographical distribution, ranging from Nicaragua to Bolivia. Reported polymorphism and the existence of more than 20 synonyms for <i>Gaiadendron punctatum</i> might indicate that there is either a cryptic complex, or that this species shows great variation. Populations from Northwestern Colombia were sampled to evaluate if local morphological variation was reflected in molecular variation. Two chloroplast regions were used, and haplotype networks were performed for each region. Also, reproductive and vegetative characters were compared between populations. Three different morphotypes were observed according to examined variables. DNA sequences showed some nucleotide substitutions and indels that characterized some of the morphotypes. Network analyses group together individuals of the same morphotype for both regions. We found evidence that the three different morphotypes here described showed some degree of genetic identity. Further work is needed for sampling along the whole distribution range of this species, to propose hypotheses about different entities or the existence of a single polymorphic taxon with altitudinal ecotypes.