cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20455136
title: Prosthetic complications and quality of life among wearers of mandibular overdenture with the Facility-Equator system

description: Abstract This longitudinal study aimed to assess the performance of the Facility-Equator system as mandibular overdenture (MO) retainers from a prosthetic perspective during 2 years of loading and to investigate the oral health-related quality of life (OHRQoL) and whether prosthetic events can affect the OHRQoL. Twenty-four patients (68.1 ± 7.51 years) reported their OHRQoL through the Geriatric Oral Health Assessment Index (GOHAI) and Oral Health Impact Profile (OHIP-EDENT) questionnaires before MO loading and after 1 and 2 years of usage. Prosthetic occurrences were recorded during this period. Data were analyzed using the Wilcoxon test, Mann-Whitney test, and Spearman correlation coefficients. Of the 127 prosthetic events that occurred in the first year, the most frequent events were prosthesis adjustments (16.5%), dislodgement of the Equator attachment (14.17%), and O-ring replacement (11.8%). Eighty-seven prosthetic events were recorded in the second year, the most frequent events being prosthesis adjustments (27.6%), O-ring replacement (20.7%), and recapturing the female matrix (11.5%). All domains of the GOHAI and OHIP-EDENT questionnaires exhibited a significant difference (p &lt; 0.05) between the baseline and 1- and 2-year evaluations, except in the Social Disability and Psychological Discomfort domains (p &gt; 0.05) of OHIP-EDENT after 1 year. Complications related to prosthetic maintenance, such as fracturing of the prosthesis, Equator dislodgement, prosthesis rebasing, and new overdenture confection, affect the OHRQoL (p &lt; 0.05), primarily the Physical Pain and Discomfort domains, especially in the first year of MO loading.
DOI: 10.6084/m9.figshare.20455136.v1
title: Prosthetic complications and quality of life among wearers of mandibular overdenture with the Facility-Equator system

description: Abstract This longitudinal study aimed to assess the performance of the Facility-Equator system as mandibular overdenture (MO) retainers from a prosthetic perspective during 2 years of loading and to investigate the oral health-related quality of life (OHRQoL) and whether prosthetic events can affect the OHRQoL. Twenty-four patients (68.1 ± 7.51 years) reported their OHRQoL through the Geriatric Oral Health Assessment Index (GOHAI) and Oral Health Impact Profile (OHIP-EDENT) questionnaires before MO loading and after 1 and 2 years of usage. Prosthetic occurrences were recorded during this period. Data were analyzed using the Wilcoxon test, Mann-Whitney test, and Spearman correlation coefficients. Of the 127 prosthetic events that occurred in the first year, the most frequent events were prosthesis adjustments (16.5%), dislodgement of the Equator attachment (14.17%), and O-ring replacement (11.8%). Eighty-seven prosthetic events were recorded in the second year, the most frequent events being prosthesis adjustments (27.6%), O-ring replacement (20.7%), and recapturing the female matrix (11.5%). All domains of the GOHAI and OHIP-EDENT questionnaires exhibited a significant difference (p &lt; 0.05) between the baseline and 1- and 2-year evaluations, except in the Social Disability and Psychological Discomfort domains (p &gt; 0.05) of OHIP-EDENT after 1 year. Complications related to prosthetic maintenance, such as fracturing of the prosthesis, Equator dislodgement, prosthesis rebasing, and new overdenture confection, affect the OHRQoL (p &lt; 0.05), primarily the Physical Pain and Discomfort domains, especially in the first year of MO loading.
DOI: 10.6084/m9.figshare.20455138
title: Smart Spectrophotometric Methods for Concurrent Determination of Furosemide and Spironolactone Mixture in Their Pharmaceutical Dosage Forms

description: Abstract Simple, precise, accurate and speciﬁc spectrophotometric methods are progressed and validated for concurrent analysis of Furosemide (FUR) and Spironolactone (SPR) in their combined dosage form depend on spectral analysis procedures. Furosemide (FUR) in the binary mixture could be analyzed at its λmax 274 nm using its recovered zero order absorption spectrum using constant multiplication method (CM). Spironolactone (SPR) in the mixture could be analyzed at its λmax 238 nm by ratio subtraction method (RS). Concurrent determination for FUR and SPR in their mixture could be applied by amplitude modulation method (AM), absorbance subtraction method (AS) and ratio difference (RD). Linearity ranges of FUR and SPR were (2.0µg/mL-22.0 µg/mL) and (3.0µg/mL-30.0 µg/mL), respectively. Specificity of the proposed spectrophotometric methods was examined by analyzing the prepared mixtures in laboratory and was applied successfully for pharmaceutical dosage form analysis which have the cited drugs without additives contribution. The proposed spectrophotometric methods were also validated as per as the guidelines of ICH. Statistical comparison was performed between the obtained results with those from the official methods of the cited drugs, using one-way ANOVA, F-test and student t-test. The results are exhibiting insignificant difference concerning precision and accuracy.
DOI: 10.6084/m9.figshare.20455138.v1
title: Smart Spectrophotometric Methods for Concurrent Determination of Furosemide and Spironolactone Mixture in Their Pharmaceutical Dosage Forms

description: Abstract Simple, precise, accurate and speciﬁc spectrophotometric methods are progressed and validated for concurrent analysis of Furosemide (FUR) and Spironolactone (SPR) in their combined dosage form depend on spectral analysis procedures. Furosemide (FUR) in the binary mixture could be analyzed at its λmax 274 nm using its recovered zero order absorption spectrum using constant multiplication method (CM). Spironolactone (SPR) in the mixture could be analyzed at its λmax 238 nm by ratio subtraction method (RS). Concurrent determination for FUR and SPR in their mixture could be applied by amplitude modulation method (AM), absorbance subtraction method (AS) and ratio difference (RD). Linearity ranges of FUR and SPR were (2.0µg/mL-22.0 µg/mL) and (3.0µg/mL-30.0 µg/mL), respectively. Specificity of the proposed spectrophotometric methods was examined by analyzing the prepared mixtures in laboratory and was applied successfully for pharmaceutical dosage form analysis which have the cited drugs without additives contribution. The proposed spectrophotometric methods were also validated as per as the guidelines of ICH. Statistical comparison was performed between the obtained results with those from the official methods of the cited drugs, using one-way ANOVA, F-test and student t-test. The results are exhibiting insignificant difference concerning precision and accuracy.
DOI: 10.6084/m9.figshare.20455139
title: Poloxamer-enhanced solubility of griseofulvin and its related antifungal activity against Trichophyton spp.

description: Abstract Poorly water-soluble drugs, such as the antifungal drug griseofulvin (GF), exhibit limited bioavailability, despite their high membrane permeability. Several technological approaches have been proposed to enhance the water solubility and bioavailability of GF, including micellar solubilization. Poloxamers are amphiphilic block copolymers that increase drug solubility by forming micelles and supra-micellar structures via molecular self-association. In this regard, the aim of this study was to evaluate the water solubility increment of GF by poloxamer 407 (P407) and its effect on the antifungal activity against three Trichophyton mentagrophytes and two T. rubrum isolates. The GF water solubility profile with P407 revealed a non-linear behavior, well-fitted by the sigmoid model of Morgan-Mercer-Flodin. The polymer promoted an 8-fold increase in GF water solubility. Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), and 2D nuclear magnetic resonance (NMR Roesy) spectroscopy suggested a GF-P407 interaction, which occurs in the GF cyclohexene ring. These results were supported by an increase in the water solubility of the GF impurities with the same molecular structure. The MIC values recorded for GF ranged from 0.0028 to 0.0172 mM, except for T. Mentagrophytes TME34. Notably, the micellar solubilization of GF did not increase its antifungal activity, which could be related to the high binding constant between GF and P407.
DOI: 10.6084/m9.figshare.20455139.v1
title: Poloxamer-enhanced solubility of griseofulvin and its related antifungal activity against Trichophyton spp.

description: Abstract Poorly water-soluble drugs, such as the antifungal drug griseofulvin (GF), exhibit limited bioavailability, despite their high membrane permeability. Several technological approaches have been proposed to enhance the water solubility and bioavailability of GF, including micellar solubilization. Poloxamers are amphiphilic block copolymers that increase drug solubility by forming micelles and supra-micellar structures via molecular self-association. In this regard, the aim of this study was to evaluate the water solubility increment of GF by poloxamer 407 (P407) and its effect on the antifungal activity against three Trichophyton mentagrophytes and two T. rubrum isolates. The GF water solubility profile with P407 revealed a non-linear behavior, well-fitted by the sigmoid model of Morgan-Mercer-Flodin. The polymer promoted an 8-fold increase in GF water solubility. Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), and 2D nuclear magnetic resonance (NMR Roesy) spectroscopy suggested a GF-P407 interaction, which occurs in the GF cyclohexene ring. These results were supported by an increase in the water solubility of the GF impurities with the same molecular structure. The MIC values recorded for GF ranged from 0.0028 to 0.0172 mM, except for T. Mentagrophytes TME34. Notably, the micellar solubilization of GF did not increase its antifungal activity, which could be related to the high binding constant between GF and P407.
DOI: 10.5281/zenodo.6976233
title: Data for NHESS manuscript by Biass et al. (2022): Insights into the vulnerability of vegetation to tephra fallouts from interpretable machine learning and big Earth observation data

description: This repository contains the data produced in the context of the following paper: Biass S, Jenkins SF, Aberhard WH, Delmelle P, Wilson T (2022): Insights into the vulnerability of vegetation to tephra fallouts from interpretable machine learning and big Earth observation data, Accepted in NHESS Naming convention is: `run_date`_`landcover`_`impact_metrics`_`VI`_`anomaly`_test.pkl, where: Landcover is either crops, shrubs, herbaceous vegetation (grass), forests (trees) or all together Impact metrics is either minV (impact magnitude) or minT (impact duration) VI is the vegetation index (here, EVI) Anomaly is the impact indicator (here, cumulative difference index) Refer to the associated paper for more information on the methodology. Files are saved as .pkl and were generated by the explainerdashboard library. They are the result of XGBoost runs that were optimised with Optuna and analysed with the SHAP library. They contain: The explanatory variables and observed and computed target variables for all features The SHAP values To load the files, use this method.
DOI: 10.6084/m9.figshare.20455153
title: Nutritional status, Na+ and Cl- concentrations, and yield of sugarcane irrigated with brackish waters

description: ABSTRACT Salinization reduces the osmotic potential of soil solutions and promotes the accumulation of toxic ions (Na+ and Cl-) in plants, causing nutritional imbalance and yield reductions. Thus, the objective of the present study was to evaluate foliar concentrations of nutrients and Na+ and stalk yields in sugarcane RB92579 under different electrical conductivities of irrigation water and leaching fractions (LF). The experiment was conducted in drainage lysimeters in a 5 × 2 factorial scheme with five electrical conductivities of irrigation water - ECw (0.5, 2.0, 4.0, 6.0, and 8.0 dS m-1) without (LF1 = 0) or with a leaching fraction (LF2 = 0.17), and four replicates. Increased ECw decreased the concentrations of N, P, K, Mg, S, Fe, Mn, Cu, and Zn and increased those of Ca, Cl, and Na, reducing the biomass production in two cycles (plant-cane and first ratoon). The use of a leaching fraction of 0.17 mitigated the deleterious effects of salinity on nutrient concentration and yield.
DOI: 10.6084/m9.figshare.20455153.v1
title: Nutritional status, Na+ and Cl- concentrations, and yield of sugarcane irrigated with brackish waters

description: ABSTRACT Salinization reduces the osmotic potential of soil solutions and promotes the accumulation of toxic ions (Na+ and Cl-) in plants, causing nutritional imbalance and yield reductions. Thus, the objective of the present study was to evaluate foliar concentrations of nutrients and Na+ and stalk yields in sugarcane RB92579 under different electrical conductivities of irrigation water and leaching fractions (LF). The experiment was conducted in drainage lysimeters in a 5 × 2 factorial scheme with five electrical conductivities of irrigation water - ECw (0.5, 2.0, 4.0, 6.0, and 8.0 dS m-1) without (LF1 = 0) or with a leaching fraction (LF2 = 0.17), and four replicates. Increased ECw decreased the concentrations of N, P, K, Mg, S, Fe, Mn, Cu, and Zn and increased those of Ca, Cl, and Na, reducing the biomass production in two cycles (plant-cane and first ratoon). The use of a leaching fraction of 0.17 mitigated the deleterious effects of salinity on nutrient concentration and yield.
DOI: 10.6084/m9.figshare.20455148.v1
title: Application of HACCP for development of quality risk management in a water purification system

description: Abstract The present work reports the implementation of the Hazard Analysis Critical Control Point (HACCP) methodology to analyze the water purification system of a pharmaceutical site, in order to assure the system quality and prevent failures. As a matter of fact, the use of HACCP for development and implementation of Quality Risk Management (QRM) is not usual in pharmaceutical plants and it is applied here to improve the performance of the water purification system of a polymerization pilot plant used to manufacture pharmaceutical grade polymer microparticles. Critical Control Points (CCP) were determined with the aid of a decision tree and questions were made to characterize whether identified hazards constitute actual CCPs and should be monitored. When deviations were detected, corrective actions were performed and action plans were used for following-up and implementation of corrective actions. Finally, microbiological and physicochemical parameters were analyzed and the obtained results were regarded as appropriate. Therefore, it is shown that HACCP constitutes an effective tool for identification of hazards, establishment of corrective actions and monitoring of the critical control points that impact the process and the quality of the final pharmaceutical product most significantly.
DOI: 10.6084/m9.figshare.20455148
title: Application of HACCP for development of quality risk management in a water purification system

description: Abstract The present work reports the implementation of the Hazard Analysis Critical Control Point (HACCP) methodology to analyze the water purification system of a pharmaceutical site, in order to assure the system quality and prevent failures. As a matter of fact, the use of HACCP for development and implementation of Quality Risk Management (QRM) is not usual in pharmaceutical plants and it is applied here to improve the performance of the water purification system of a polymerization pilot plant used to manufacture pharmaceutical grade polymer microparticles. Critical Control Points (CCP) were determined with the aid of a decision tree and questions were made to characterize whether identified hazards constitute actual CCPs and should be monitored. When deviations were detected, corrective actions were performed and action plans were used for following-up and implementation of corrective actions. Finally, microbiological and physicochemical parameters were analyzed and the obtained results were regarded as appropriate. Therefore, it is shown that HACCP constitutes an effective tool for identification of hazards, establishment of corrective actions and monitoring of the critical control points that impact the process and the quality of the final pharmaceutical product most significantly.
DOI: 10.6084/m9.figshare.20455154
title: Leaching and availability of potassium in soil affected by conventional and coated fertilizer sources

description: ABSTRACT The use of coated fertilizers is a strategy for improving fertilization efficiency and crop yield. However, further studies are needed to understand the dynamics of different types of coated K fertilizers in the soil. The objective of this study was to evaluate K dynamics in soil columns after the application of conventional KCl and other K sources with coating (KCl-C) and compaction (KCl-CC) combined with the use of additives and polymers. The experiment comprised four treatments, consisting of three sources of K [conventional KCl, KCl coated with additives and polymers (KCl-C), and KCl compacted and coated with additives and polymers (KCl-CC)], and a control without K application, with four repetitions. The K concentration was evaluated in the leached solution collected from the soil columns for 28 days. After this period, the K concentration in the soil was determined. The absence of K fertilization in the soil led to a 26.5% reduction in the K concentration. The coated sources had lower granule hardness and higher K leaching than conventional KCl. The amounts of K leached were 62.2%, 68.5%, and 54.0% for KCl-CC, KCl-C, and conventional KCl, respectively. However, at the end of the experiment, the soil K concentration was higher under the KCl-C treatment.
DOI: 10.6084/m9.figshare.20455154.v1
title: Leaching and availability of potassium in soil affected by conventional and coated fertilizer sources

description: ABSTRACT The use of coated fertilizers is a strategy for improving fertilization efficiency and crop yield. However, further studies are needed to understand the dynamics of different types of coated K fertilizers in the soil. The objective of this study was to evaluate K dynamics in soil columns after the application of conventional KCl and other K sources with coating (KCl-C) and compaction (KCl-CC) combined with the use of additives and polymers. The experiment comprised four treatments, consisting of three sources of K [conventional KCl, KCl coated with additives and polymers (KCl-C), and KCl compacted and coated with additives and polymers (KCl-CC)], and a control without K application, with four repetitions. The K concentration was evaluated in the leached solution collected from the soil columns for 28 days. After this period, the K concentration in the soil was determined. The absence of K fertilization in the soil led to a 26.5% reduction in the K concentration. The coated sources had lower granule hardness and higher K leaching than conventional KCl. The amounts of K leached were 62.2%, 68.5%, and 54.0% for KCl-CC, KCl-C, and conventional KCl, respectively. However, at the end of the experiment, the soil K concentration was higher under the KCl-C treatment.
DOI: 10.6084/m9.figshare.20455156
title: Effect of the cranberry ( Vaccinium macrocarpon ) juice on reducing dentin erosion: an in vitro study

description: Abstract Vaccinium macrocarpon (cranberry) is a fruit that has an inhibitory effect on matrix metalloproteinases (MMPs) present in dentin and saliva. The inhibition of MMPs has been shown to prevent dentin erosion. The aim of this study was to analyze the effect of cranberry juice on the reduction of dentin erosion in vitro. Specimens of bovine dentin (4×4×2 mm) were randomized and divided into 4 groups (n = 17/group): distilled water (C-control, pH 7.2); green tea extract solution containing 400 µm epigallo-catechin-gallate (EGCg, positive control, pH 4.5); 10% cranberry extract (CrE, pH 3.9), and cranberry juice (CrJ, Cranberry JuxxTM, pH 2.8). Specimens were submitted to erosive pH cycles for 5 days. Each day, four demineralizations were carried out with 0.1% citric acid (90 s). After the acid challenges, specimens were rinsed and kept in treatment solutions for 1 min; afterwards, they were rinsed and stored in artificial saliva for 1 h at 37°C (or overnight at the end of each day). After the experimental period of 5 days, dentin loss was evaluated by contact profilometry. Data were analyzed by ANOVA and Tukey’s test (p &lt; 0.05). Dentin loss (µm ± SD) was significantly lower for all treatments (EGCg = 9.93 ± 2.90; CrE = 12.10 ± 5.44; CrJ = 11.04 ± 5.70) compared to control (21.23 ± 11.96), but it did not significantly differ from each other. These results indicate that the commercial cranberry juice, despite its low pH, is able to reduce dentin erosion, which might be due to the ability of cranberry components to inhibit MMPs.
DOI: 10.6084/m9.figshare.20455156.v1
title: Effect of the cranberry ( Vaccinium macrocarpon ) juice on reducing dentin erosion: an in vitro study

description: Abstract Vaccinium macrocarpon (cranberry) is a fruit that has an inhibitory effect on matrix metalloproteinases (MMPs) present in dentin and saliva. The inhibition of MMPs has been shown to prevent dentin erosion. The aim of this study was to analyze the effect of cranberry juice on the reduction of dentin erosion in vitro. Specimens of bovine dentin (4×4×2 mm) were randomized and divided into 4 groups (n = 17/group): distilled water (C-control, pH 7.2); green tea extract solution containing 400 µm epigallo-catechin-gallate (EGCg, positive control, pH 4.5); 10% cranberry extract (CrE, pH 3.9), and cranberry juice (CrJ, Cranberry JuxxTM, pH 2.8). Specimens were submitted to erosive pH cycles for 5 days. Each day, four demineralizations were carried out with 0.1% citric acid (90 s). After the acid challenges, specimens were rinsed and kept in treatment solutions for 1 min; afterwards, they were rinsed and stored in artificial saliva for 1 h at 37°C (or overnight at the end of each day). After the experimental period of 5 days, dentin loss was evaluated by contact profilometry. Data were analyzed by ANOVA and Tukey’s test (p &lt; 0.05). Dentin loss (µm ± SD) was significantly lower for all treatments (EGCg = 9.93 ± 2.90; CrE = 12.10 ± 5.44; CrJ = 11.04 ± 5.70) compared to control (21.23 ± 11.96), but it did not significantly differ from each other. These results indicate that the commercial cranberry juice, despite its low pH, is able to reduce dentin erosion, which might be due to the ability of cranberry components to inhibit MMPs.
DOI: 10.5281/zenodo.6818050
title: Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"

description: These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. <em>Format: tab-separated-value.</em> <em>Fields:</em> <em>gene_stable_id: Ensembl gene id</em> <em>gene_name: standard gene name</em> <em>pvalue: burden test significance (likelihood ratio test, population structure correction based on 6 PCA components)</em> <em>cmac_all: sum of minor allele dosages across all contributing samples and variants</em> <em>group: variant group (LOF, LOF+REVEL&gt;=75, LOF+REVEL&gt;=50, LOF+REVEL&gt;=25, see publication methods for further selection criteria).</em> <em>beta/se: beta/se of logistic ordinal regression (see publication methods). Positive = risk-increasing. Negative = risk-decreasing.</em>