cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5909005.v1
title: Dataset for: Capturing the multifactorial nature of ARDS- “Two-hit” approach to model murine acute lung injury

description: Severe acute respiratory distress syndrome (ARDS) presents typically with an initializing event, followed by the need for mechanical ventilation. Most animal models of ALI are limited by the fact that they focus on a singular cause of acute lung injury (ALI) and therefore fail to mimic the complex, multifactorial pathobiology of ARDS. To better capture this scenario, we provide a comprehensive characterization of models of ALI combining two injuries: intra tracheal (i.t.) instillation of LPS or hypochloric acid (HCl) followed by ventilator-induced lung injury (VILI). We hypothesized, that mice pre-treated with LPS or HCl prior to VILI and thus receiving a (“ two-hit injury”) will sustain a super additive lung injury when compared to VILI. Mice were allocated to following treatment groups: control with i.t. NaCl, ventilation with low peak inspiratory pressure (PIP), i.t. HCl, i.t. LPS, VILI (high PIP), HCl i.t. followed by VILI and LPS i.t. followed by VILI. Severity of injury was determined by protein content and MPO activity in bronchoalveolar lavage (BAL), expression of inflammatory cytokines and histopathology. Mice subjected to VILI after HCl or LPS instillation displayed augmented lung injury, compared to singular lung injury. However, mice that received i.t. LPS prior to VILI showed significantly increased inflammatory lung injury compared to animals that underwent i.t. HCl followed by VILI. The two hit lung injury models described, resulting in additive but differential acute lung injury recaptures the clinical relevant multifactorial etiology of ALI and could be a valuable tool in translational research.
DOI: 10.6084/m9.figshare.5908963
title: Supplementary Material for: Successful Treatment of Differentiated Thyroid Carcinoma with Transaxillary Robotic Surgery and Radioiodine: The First European Experience

description: <b><i>Objectives:</i></b> Transaxillary robotic thyroidectomy surgery (TARS) has been reported to be a safe approach in patients with differentiated thyroid carcinoma, and oncological responses are promising. <b><i>Study Design:</i></b> This study aimed to evaluate the oncological outcomes of TARS followed by radioiodine (RAI) therapy in patients with differentiated thyroid carcinoma. Between 2011 and 2016, patients treated for differentiated thyroid carcinoma by TARS in a single institution, followed by RAI, were retrospectively included. The oncological response was performed according to the 2015 American Thyroid Association (ATA) guidelines 6–12 months later and at the last available visit. <b><i>Results:</i></b> A total of 42 patients (30 females) were included, with a median tumor size of 20 mm (12 cases of N1a and 5 cases of N1b on initial pathology report). According to ATA classification of recurrence risk after surgery, 17 and 25 patients were classified as low and intermediate risk, respectively. After RAI, all patients had a normal posttherapeutic whole body scan (except 1 patient, who had pathological lymph node uptake), but no unusual uptake was seen. At the 6- to 12-month evaluation (<i>n</i> = 37), 24 patients had excellent response, 8 had indeterminate response, and 5 had incomplete response (2 biological and 3 structural); no distant metastasis was found. At the last evaluation (median follow-up 15.9 months), 35 patients had no evidence of disease and 1 patient had a structural incomplete response. In total, a second open surgery was necessary for 3 patients to treat persistent lymph nodes (all intermediate risk). <b><i>Conclusion:</i></b> In this study, TARS followed by RAI therapy seems to be curative, even for patients with lymph node metastases, after good preoperative staging. More studies are required to confirm the findings.
DOI: 10.6084/m9.figshare.5908948
title: Supplementary Material for: Low Discontinuation Rate of Infliximab Treatment in Steroid-Dependent/Refractory Crohn’s Disease Patients

description: <b><i>Background:</i></b> Many patients with moderate to severe Crohn’s disease (CD) are treated with infliximab (IFX). As most of these patients experience a long-lasting therapy, the outcome and withdrawal of IFX treatment are important clinical questions. <b><i>Methods:</i></b> In this retrospective study, we analyzed the treatment outcome in moderate to severe CD patients with a steroid-dependent/refractory disease course started on IFX. Withdrawal of IFX was evaluated in patients with deep remission defined as clinical (Harvey-Bradshaw Index ≤4), biochemical (fecal calprotectin [FC] ≤150 μg/g stool) over a period of 2 years, and endoscopic and histological remission before discontinuation of IFX. <b><i>Results:</i></b> After induction with IFX, clinical remission was observed in 45/109 patients (41.3%) and clinical response in 61/109 patients (56.0%). Only 8/109 patients (7.3%) achieved deep remission and therefore could be discontinued from IFX therapy. In 4 of these patients (50%), relapse was observed after discontinuation of IFX treatment. FC decreased in these 8 patients in deep remission from 652 ± 168 μg/g stool (mean ± SE) at baseline to 24.9 ± 8.1 μg/g stool at 14 weeks. When compared to patients in deep remission, FC had decreased significantly less at 14 weeks in patients in clinical remission after induction with IFX (<i>n</i> = 31; 154 ± 55 μg/g stool; <i>p</i> = 0.01), in patients with clinical response after induction achieving clinical remission during the maintenance phase (<i>n</i> = 11; 352 ± 67 μg/g stool; <i>p</i> = 0.004), or in patients with chronic active disease course on maintenance therapy (<i>n</i> = 50; 645 ± 93 μg/g stool; <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> A low discontinuation rate was observed for steroid-dependent/refractory moderate to severe CD patients with IFX treatment. As FC showed a more or less pronounced decrease depending on the response to the IFX treatment, monitoring of FC may become a noninvasive tool for tailoring biological therapy in CD patients.
DOI: 10.6084/m9.figshare.5908948.v1
title: Supplementary Material for: Low Discontinuation Rate of Infliximab Treatment in Steroid-Dependent/Refractory Crohn’s Disease Patients

description: <b><i>Background:</i></b> Many patients with moderate to severe Crohn’s disease (CD) are treated with infliximab (IFX). As most of these patients experience a long-lasting therapy, the outcome and withdrawal of IFX treatment are important clinical questions. <b><i>Methods:</i></b> In this retrospective study, we analyzed the treatment outcome in moderate to severe CD patients with a steroid-dependent/refractory disease course started on IFX. Withdrawal of IFX was evaluated in patients with deep remission defined as clinical (Harvey-Bradshaw Index ≤4), biochemical (fecal calprotectin [FC] ≤150 μg/g stool) over a period of 2 years, and endoscopic and histological remission before discontinuation of IFX. <b><i>Results:</i></b> After induction with IFX, clinical remission was observed in 45/109 patients (41.3%) and clinical response in 61/109 patients (56.0%). Only 8/109 patients (7.3%) achieved deep remission and therefore could be discontinued from IFX therapy. In 4 of these patients (50%), relapse was observed after discontinuation of IFX treatment. FC decreased in these 8 patients in deep remission from 652 ± 168 μg/g stool (mean ± SE) at baseline to 24.9 ± 8.1 μg/g stool at 14 weeks. When compared to patients in deep remission, FC had decreased significantly less at 14 weeks in patients in clinical remission after induction with IFX (<i>n</i> = 31; 154 ± 55 μg/g stool; <i>p</i> = 0.01), in patients with clinical response after induction achieving clinical remission during the maintenance phase (<i>n</i> = 11; 352 ± 67 μg/g stool; <i>p</i> = 0.004), or in patients with chronic active disease course on maintenance therapy (<i>n</i> = 50; 645 ± 93 μg/g stool; <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> A low discontinuation rate was observed for steroid-dependent/refractory moderate to severe CD patients with IFX treatment. As FC showed a more or less pronounced decrease depending on the response to the IFX treatment, monitoring of FC may become a noninvasive tool for tailoring biological therapy in CD patients.
DOI: 10.6084/m9.figshare.5908873
title: The clinical characteristics of Kleine–Levin syndrome according to ethnicity and geographic location

description: <b>Purpose:</b> Kleine–Levin syndrome (KLS) is a rare, relapsing-remitting, debilitating sleep disorder. Examining KLS characteristics in different ethnic populations may help elucidate the genetic basis of the disorder. No studies have examined KLS in Arabs. Therefore, we compared the clinical characteristics of Saudi Arabian KLS patients to those in other published cohorts to determine whether Arab patients have a distinct phenotype. <b>Methods:</b> This study included all patients who were diagnosed with KLS at our center between June 2003 and July 2016 (<i>P</i> = 12; Six familial cases). All participants completed the Stanford KLS questionnaire. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale; eating attitudes were assessed with the Eating Attitudes Test-26. We compared the clinical characteristics of our patients to those in other published cohorts. <b>Results:</b> Saudi Arabian patients with KLS had similar features to those in patients from different countries and ethnic backgrounds, with only minor differences in sleep duration during disease episodes (2–3 h shorter). However, between episodes, Saudi Arabian KLS patients reported worse sleep, greater daytime sleepiness and higher levels of baseline depression, which may be related to KLS or to local cultural practices. Ankylosing spondylitis was present in five of the six familial patients. <b>Conclusion:</b> Saudi Arabian patients with KLS exhibited similar clinical characteristics during episodes compared to patients with KLS of different ethnicities. However, a new and interesting finding is that KLS patients may have inter-episode behavioral and pathophysiological changes, which may suggest that KLS is not necessarily a static disorder.
DOI: 10.6084/m9.figshare.5908873.v1
title: The clinical characteristics of Kleine–Levin syndrome according to ethnicity and geographic location

description: <b>Purpose:</b> Kleine–Levin syndrome (KLS) is a rare, relapsing-remitting, debilitating sleep disorder. Examining KLS characteristics in different ethnic populations may help elucidate the genetic basis of the disorder. No studies have examined KLS in Arabs. Therefore, we compared the clinical characteristics of Saudi Arabian KLS patients to those in other published cohorts to determine whether Arab patients have a distinct phenotype. <b>Methods:</b> This study included all patients who were diagnosed with KLS at our center between June 2003 and July 2016 (<i>P</i> = 12; Six familial cases). All participants completed the Stanford KLS questionnaire. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale; eating attitudes were assessed with the Eating Attitudes Test-26. We compared the clinical characteristics of our patients to those in other published cohorts. <b>Results:</b> Saudi Arabian patients with KLS had similar features to those in patients from different countries and ethnic backgrounds, with only minor differences in sleep duration during disease episodes (2–3 h shorter). However, between episodes, Saudi Arabian KLS patients reported worse sleep, greater daytime sleepiness and higher levels of baseline depression, which may be related to KLS or to local cultural practices. Ankylosing spondylitis was present in five of the six familial patients. <b>Conclusion:</b> Saudi Arabian patients with KLS exhibited similar clinical characteristics during episodes compared to patients with KLS of different ethnicities. However, a new and interesting finding is that KLS patients may have inter-episode behavioral and pathophysiological changes, which may suggest that KLS is not necessarily a static disorder.
DOI: 10.6084/m9.figshare.5908729
title: Additional file 8: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S6. Variations in bacterial (16S rRNA gene) and Symbiodinium (ITS2) communities explained by the addition of significant variables for the reduced models identified using RDA and forwardselection procedures. (XLSX 38Â kb)
DOI: 10.6084/m9.figshare.5908729.v1
title: Additional file 8: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S6. Variations in bacterial (16S rRNA gene) and Symbiodinium (ITS2) communities explained by the addition of significant variables for the reduced models identified using RDA and forwardselection procedures. (XLSX 38Â kb)
DOI: 10.6084/m9.figshare.5908714
title: Additional file 2: of The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development

description: Spreadsheet containing Tables S2A-D. The spreadsheet contains information on the libraries used for assembly and annotation of the A. limnaeus genome. In addition, the spreadsheet contains information on the RNA-seq libraries used for differential expression analysis. (XLSX 65 kb)
DOI: 10.6084/m9.figshare.5908714.v1
title: Additional file 2: of The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development

description: Spreadsheet containing Tables S2A-D. The spreadsheet contains information on the libraries used for assembly and annotation of the A. limnaeus genome. In addition, the spreadsheet contains information on the RNA-seq libraries used for differential expression analysis. (XLSX 65 kb)
DOI: 10.6084/m9.figshare.5908708
title: Additional file 7: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S5. Number of bacterial sequences and positive samples for each region at the family and genus levels. Taxa shared by at least 50% of samples in one population are colored in light gray, whereas taxa shared by at least 50% of the overall samples are colored in dark gray. We considered as core microbiota the taxa shared by 50% of samples for each of the four populations (regions) studied. (XLSX 128Â kb)
DOI: 10.6084/m9.figshare.5908708.v1
title: Additional file 7: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S5. Number of bacterial sequences and positive samples for each region at the family and genus levels. Taxa shared by at least 50% of samples in one population are colored in light gray, whereas taxa shared by at least 50% of the overall samples are colored in dark gray. We considered as core microbiota the taxa shared by 50% of samples for each of the four populations (regions) studied. (XLSX 128Â kb)
DOI: 10.6084/m9.figshare.5908696
title: Additional file 1: of The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development

description: Spreadsheet containing Tables S1A-J. The spreadsheet contains supplemental information on the species used for clustering analysis, positive selection results, GO term enrichment results, differential transcript abundance results, and Hsp70 family transcript abundance results. (XLSX 997 kb)
DOI: 10.6084/m9.figshare.5908696.v1
title: Additional file 1: of The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development

description: Spreadsheet containing Tables S1A-J. The spreadsheet contains supplemental information on the species used for clustering analysis, positive selection results, GO term enrichment results, differential transcript abundance results, and Hsp70 family transcript abundance results. (XLSX 997 kb)
DOI: 10.6084/m9.figshare.5908687
title: Additional file 6: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S4. Diversity indices calculated on bacterial diversity for each sample and statistical analyses of differences between regions. (XLSX 136Â kb)
DOI: 10.6084/m9.figshare.5908687.v1
title: Additional file 6: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S4. Diversity indices calculated on bacterial diversity for each sample and statistical analyses of differences between regions. (XLSX 136Â kb)
DOI: 10.6084/m9.figshare.5908678
title: Additional file 5: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S3. Bacterial OTU table with sequence tag counts per sample and taxonomic affiliation. (XLSX 49Â kb)
DOI: 10.6084/m9.figshare.5908678.v1
title: Additional file 5: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S3. Bacterial OTU table with sequence tag counts per sample and taxonomic affiliation. (XLSX 49Â kb)
DOI: 10.6084/m9.figshare.12894740
title: Socio-demographic and Lifestyle factors associated with Understanding Fast Food Consumption among Adults in Cambodia

description: Underlying data<br>
DOI: 10.6084/m9.figshare.5908633
title: Additional file 3: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S2. Symbiodinium OTU table with sequence tag counts per sample and taxonomic affiliation (XLSX 62Â kb)
DOI: 10.6084/m9.figshare.5908633.v1
title: Additional file 3: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S2. Symbiodinium OTU table with sequence tag counts per sample and taxonomic affiliation (XLSX 62Â kb)
DOI: 10.6084/m9.figshare.5908588
title: Additional file 1: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S1. Sample metadata including geographic and abiotic variables (temperature descriptors) as well as Pocillopora haplotype identification. (XLSX 55Â kb)
DOI: 10.6084/m9.figshare.5908588.v1
title: Additional file 1: of Thermal regime and host clade, rather than geography, drive Symbiodinium and bacterial assemblages in the scleractinian coral Pocillopora damicornis sensu lato

description: Table S1. Sample metadata including geographic and abiotic variables (temperature descriptors) as well as Pocillopora haplotype identification. (XLSX 55Â kb)
DOI: 10.6084/m9.figshare.5908573
title: MOESM5 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 5. nextRAD sample collection information, number of sequence reads, and unique stacks genotyped. Includes collection and sequencing details for all 320 individuals sequenced, and Stacks details for 162 individuals included in Stacks and downstream analyses.
DOI: 10.6084/m9.figshare.5908573.v1
title: MOESM5 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 5. nextRAD sample collection information, number of sequence reads, and unique stacks genotyped. Includes collection and sequencing details for all 320 individuals sequenced, and Stacks details for 162 individuals included in Stacks and downstream analyses.
DOI: 10.6084/m9.figshare.5908558
title: MOESM4 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 4. STRUCTURE file used for STRUCTURE, PCA and DAPC analyses, with genotypes for 162 individuals at 1,021 loci.
DOI: 10.6084/m9.figshare.5908558.v1
title: MOESM4 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 4. STRUCTURE file used for STRUCTURE, PCA and DAPC analyses, with genotypes for 162 individuals at 1,021 loci.
DOI: 10.6084/m9.figshare.5908549
title: Additional file 3: of Effectiveness of a field trap barrier system for controlling Aedes albopictus: a “removal trapping” strategy

description: Table S1. Database of the results analyzed in the present study. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.5908549.v1
title: Additional file 3: of Effectiveness of a field trap barrier system for controlling Aedes albopictus: a “removal trapping” strategy

description: Table S1. Database of the results analyzed in the present study. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.5908546
title: MOESM3 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 3. Bash scripts with commands used to align the sequencing reads to the Anopheles darlingi genome scaffolds and to run the Stacks pipeline.
DOI: 10.6084/m9.figshare.5908546.v1
title: MOESM3 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 3. Bash scripts with commands used to align the sequencing reads to the Anopheles darlingi genome scaffolds and to run the Stacks pipeline.
DOI: 10.6084/m9.figshare.5908522
title: MOESM2 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 2. Dataset of Anopheles darlingi counts by collection, month, year, site, exophagic/endophagic, and time period. Collections in Cahuide and Lupuna from 2013-2015 and in Santa Emilia from 2015 are included.
DOI: 10.6084/m9.figshare.5908522.v1
title: MOESM2 of Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru

description: Additional file 2. Dataset of Anopheles darlingi counts by collection, month, year, site, exophagic/endophagic, and time period. Collections in Cahuide and Lupuna from 2013-2015 and in Santa Emilia from 2015 are included.
DOI: 10.6084/m9.figshare.5908492
title: MOESM2 of Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

description: Additional file 2: Table S1. Number of differentially expressed genes in the different groups and conditions. Table S2. Previous measurements: List of variables measured. Table S3. Network modules: HotNet2 results. Table S4. Network modules: HotNet2 consensus. Table S5. Network modules: Functional characterization. Table S6. Network modules: Gene differential expression. Table S7. Previous measurements: Differentials. Table S8. Previous measurements: Association with network modules. Table S9. Comparison of microarray results with qPCR validation of external datasets.