cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6503405
title: In Vitro and In Vivo Biocompatibility Of ReOss® in Powder and Putty Configurations

description: Article This study evaluated comparatively two configurations (powder and putty) of a composite biomaterial based on PLGA (Poly(lactide-co-glycolide)/nanoescale hydroxyapatite (ReOss®, Intra-Lock International) through microscopic morphology, in vitro cytotoxicity, biocompatibility and in vivo response as a bone substitute. SEM and EDS characterized the biomaterials before/after grafting. Cytocompatibility was assessed with murine pre-osteoblasts. Osteoconductivity and biocompatibility were evaluated in White New Zealand rabbits. Both configurations were implanted in the calvaria of eighteen animals in non-critical size defects, with blood clot as the control group. After 30, 60 and 90 days, the animals were euthanized and the fragments containing the biomaterials and controls were harvested. Bone blocks were embedded in paraffin (n=15) aiming at histological and histomorphometric analysis, and in resin (n=3) aiming at SEM and EDS. Before implantation, the putty configuration showed both a porous and a fibrous morphological phase. Powder revealed porous particles with variable granulometry. EDS showed calcium, carbon, and oxygen in putty configuration, while powder also showed phosphorus. After implantation EDS revealed calcium, carbon, and oxygen in both configurations. The materials were considered cytotoxic by the XTT test. Histological analysis showed new bone formation and no inflammatory reaction at implant sites. However, the histomorphometric analysis indicated that the amount of newly formed bone was not statistically different between experimental groups. Although both materials presented in vitro cytotoxicity, they were biocompatible and osteoconductive. The configuration of ReOss® affected morphological characteristics and the in vitro cytocompatibility but did not impact on the in vivo biological response, as measured by the present model.
DOI: 10.6084/m9.figshare.6503405.v1
title: In Vitro and In Vivo Biocompatibility Of ReOss® in Powder and Putty Configurations

description: Article This study evaluated comparatively two configurations (powder and putty) of a composite biomaterial based on PLGA (Poly(lactide-co-glycolide)/nanoescale hydroxyapatite (ReOss®, Intra-Lock International) through microscopic morphology, in vitro cytotoxicity, biocompatibility and in vivo response as a bone substitute. SEM and EDS characterized the biomaterials before/after grafting. Cytocompatibility was assessed with murine pre-osteoblasts. Osteoconductivity and biocompatibility were evaluated in White New Zealand rabbits. Both configurations were implanted in the calvaria of eighteen animals in non-critical size defects, with blood clot as the control group. After 30, 60 and 90 days, the animals were euthanized and the fragments containing the biomaterials and controls were harvested. Bone blocks were embedded in paraffin (n=15) aiming at histological and histomorphometric analysis, and in resin (n=3) aiming at SEM and EDS. Before implantation, the putty configuration showed both a porous and a fibrous morphological phase. Powder revealed porous particles with variable granulometry. EDS showed calcium, carbon, and oxygen in putty configuration, while powder also showed phosphorus. After implantation EDS revealed calcium, carbon, and oxygen in both configurations. The materials were considered cytotoxic by the XTT test. Histological analysis showed new bone formation and no inflammatory reaction at implant sites. However, the histomorphometric analysis indicated that the amount of newly formed bone was not statistically different between experimental groups. Although both materials presented in vitro cytotoxicity, they were biocompatible and osteoconductive. The configuration of ReOss® affected morphological characteristics and the in vitro cytocompatibility but did not impact on the in vivo biological response, as measured by the present model.
DOI: 10.6084/m9.figshare.6503402
title: Sorghum yield after liming and combinations of phosphorus sources

description: ABSTRACT Phosphate fertilization has increased sorghum yield, but few studies are available on sorghum production and efficient fertilizer management related to liming and phosphorus (P) sources. This work evaluates production, dry matter partitioning and agronomic efficiency (AEI) in successive sorghum cycles after application of limestone and combinations of phosphorus sources. Two cycles were conducted in sequence in the same experimental field, in a 2 x 6 factorial scheme, corresponding to soil with or without liming and six combinations of P2O5 sources: control (0 kg ha-1 P2O5), 100% Itafós natural phosphate (NP), 75% NP + 25% single superphosphate (SS), 50% NP + 50% SS, 25% NP + 75% SS and 100% SS. Pots with capacity for 8 dm3 were used in a randomized block design with four replicates. The first cycle, conducted in the summer/autumn season, reached the highest dry matter production and P accumulation in treatments with higher SS proportions, leading to higher AEI. Subsequently, in the second cycle, conducted considering only the residual phosphate fertilization of the first cycle, highest dry matter production and AEI were obtained in the treatment with 100% or higher proportions of natural phosphate in the presence of liming, most likely due to the gradual release of P.
DOI: 10.6084/m9.figshare.6503402.v1
title: Sorghum yield after liming and combinations of phosphorus sources

description: ABSTRACT Phosphate fertilization has increased sorghum yield, but few studies are available on sorghum production and efficient fertilizer management related to liming and phosphorus (P) sources. This work evaluates production, dry matter partitioning and agronomic efficiency (AEI) in successive sorghum cycles after application of limestone and combinations of phosphorus sources. Two cycles were conducted in sequence in the same experimental field, in a 2 x 6 factorial scheme, corresponding to soil with or without liming and six combinations of P2O5 sources: control (0 kg ha-1 P2O5), 100% Itafós natural phosphate (NP), 75% NP + 25% single superphosphate (SS), 50% NP + 50% SS, 25% NP + 75% SS and 100% SS. Pots with capacity for 8 dm3 were used in a randomized block design with four replicates. The first cycle, conducted in the summer/autumn season, reached the highest dry matter production and P accumulation in treatments with higher SS proportions, leading to higher AEI. Subsequently, in the second cycle, conducted considering only the residual phosphate fertilization of the first cycle, highest dry matter production and AEI were obtained in the treatment with 100% or higher proportions of natural phosphate in the presence of liming, most likely due to the gradual release of P.
DOI: 10.6084/m9.figshare.6503399
title: Dental caries in schoolchildren: influence of inattention, hyperactivity and executive functions

description: Abstract Attention-deficit/hyperactivity disorder (ADHD) is characterized by inappropriate levels of hyperactivity, impulsivity, and/or inattention. Individuals with ADHD may present limitations with regard to executive functions and performing activities that involve planning and/or attention/concentration. The aim of the study was to investigate the association between dental caries and signs of ADHD in a representative sample of schoolchildren. A representative sample of 851 schoolchildren aged seven to 12 years was randomly selected from public and private schools. Data acquisition involved a clinical dental examination for cavitated permanent and deciduous teeth using the DMFT/dmft indices. Neuropsychological evaluations, including the assessment of intelligence (Raven’s Colored Progressive Matrix Test) and executive functions (Corsi Tapping Blocks tests and Digit Span test) were also performed. Parents/caregivers and teachers answered the SNAP-IV Questionnaire for the investigation of signs of inattention and hyperactivity in the family and school environment. Parents/caregivers also answered questionnaires addressing socioeconomic and socio-demographic characteristics. Descriptive analysis of the variables and Poisson regression with robust variance were performed. Parental reports of signs of inattention (PR: 1.28; p &lt; 0.05) and hyperactivity (PR: 1.15; p &lt; 0.05) were associated with a greater occurrence of caries. A better performance on the backward order of the Corsi Tapping Blocks tests (PR: 0.94; p &lt; 0.05) and higher level of mother’s schooling were associated with a lower frequency of caries. A better performance on executive function tasks was a protective factor against dental caries, whereas children considered inattentive and/or hyperactive by their parents had a higher prevalence rate of dental caries.
DOI: 10.6084/m9.figshare.6503399.v1
title: Dental caries in schoolchildren: influence of inattention, hyperactivity and executive functions

description: Abstract Attention-deficit/hyperactivity disorder (ADHD) is characterized by inappropriate levels of hyperactivity, impulsivity, and/or inattention. Individuals with ADHD may present limitations with regard to executive functions and performing activities that involve planning and/or attention/concentration. The aim of the study was to investigate the association between dental caries and signs of ADHD in a representative sample of schoolchildren. A representative sample of 851 schoolchildren aged seven to 12 years was randomly selected from public and private schools. Data acquisition involved a clinical dental examination for cavitated permanent and deciduous teeth using the DMFT/dmft indices. Neuropsychological evaluations, including the assessment of intelligence (Raven’s Colored Progressive Matrix Test) and executive functions (Corsi Tapping Blocks tests and Digit Span test) were also performed. Parents/caregivers and teachers answered the SNAP-IV Questionnaire for the investigation of signs of inattention and hyperactivity in the family and school environment. Parents/caregivers also answered questionnaires addressing socioeconomic and socio-demographic characteristics. Descriptive analysis of the variables and Poisson regression with robust variance were performed. Parental reports of signs of inattention (PR: 1.28; p &lt; 0.05) and hyperactivity (PR: 1.15; p &lt; 0.05) were associated with a greater occurrence of caries. A better performance on the backward order of the Corsi Tapping Blocks tests (PR: 0.94; p &lt; 0.05) and higher level of mother’s schooling were associated with a lower frequency of caries. A better performance on executive function tasks was a protective factor against dental caries, whereas children considered inattentive and/or hyperactive by their parents had a higher prevalence rate of dental caries.
DOI: 10.6084/m9.figshare.6503393
title: YTTRIUM ALUMINUM OXIDE DOPED WITH Yb3+AND Er3+ INCORPORATED INTO POLYAMIDE MEMBRANE

description: Lanthanide ions have special light emission, which can occur through descending and ascending energy conversion. Ascending energy conversion is especially interesting for bioapplications because excitation in the infrared region does not excite biomolecules and therefore does not interfere in detection, not to mention that it penetrates deeper in the skin. Here, we synthesized yttrium and aluminum oxide doped with Yb3+and Er3+ions via the non-hydrolytic sol-gel methodology. The doped matrix was incorporated and dispersed over a polyamide membrane obtained by Additive Manufacturing. X-ray diffraction revealed that a mixture of yttrium aluminum monoclinic and garnet phases emerged. Upon excitation at 980 nm in the Yb3+ion, the Er3+ presented more intense emission as a function of the laser power, which favored red emission. The intensities of the bands corresponding to the 4S3/2 → 4I15/2 (563 nm) and 5F9/2 → 4I15/2 (660 nm) transitions involved the absorption of two photons. The oxide incorporated into the polyamide membrane presented the same behavior. After coating with polyetherimide, the latter system was resistant to 5.1 W laser, which paves the way for new applications.
DOI: 10.6084/m9.figshare.6503393.v1
title: YTTRIUM ALUMINUM OXIDE DOPED WITH Yb3+AND Er3+ INCORPORATED INTO POLYAMIDE MEMBRANE

description: Lanthanide ions have special light emission, which can occur through descending and ascending energy conversion. Ascending energy conversion is especially interesting for bioapplications because excitation in the infrared region does not excite biomolecules and therefore does not interfere in detection, not to mention that it penetrates deeper in the skin. Here, we synthesized yttrium and aluminum oxide doped with Yb3+and Er3+ions via the non-hydrolytic sol-gel methodology. The doped matrix was incorporated and dispersed over a polyamide membrane obtained by Additive Manufacturing. X-ray diffraction revealed that a mixture of yttrium aluminum monoclinic and garnet phases emerged. Upon excitation at 980 nm in the Yb3+ion, the Er3+ presented more intense emission as a function of the laser power, which favored red emission. The intensities of the bands corresponding to the 4S3/2 → 4I15/2 (563 nm) and 5F9/2 → 4I15/2 (660 nm) transitions involved the absorption of two photons. The oxide incorporated into the polyamide membrane presented the same behavior. After coating with polyetherimide, the latter system was resistant to 5.1 W laser, which paves the way for new applications.
DOI: 10.6084/m9.figshare.6503390
title: Immediate laser-induced hemostasis in anticoagulated rats subjected to oral soft tissue surgery: a double-blind study

description: Abstract Given the growing trend towards medical indications for continuous use of anticoagulants, the number of patients on these medications continues to rise. The management of patients on oral anticoagulants requiring oral surgical procedures has aroused much controversy. Changes in an anticoagulation regimen are associated with an increased risk of thromboembolism. However, it seems logical and advantageous for the patients’ health if surgery could be performed without any change to the anticoagulation therapy. In dentistry, high-power lasers have been poorly explored in this field. The hemostatic properties of high-power lasers could be helpful during oral soft tissue surgeries in anticoagulated patients. The aim of this study was to compare bleeding time in anticoagulated rats after lingual frenectomy performed with a scalpel or diode laser with bleeding time in healthy animals. Twenty-four male Wistar rats were assigned to four groups (n = 6): (CS) Control-Scalpel Surgery; (AS) Anticoagulated-Scalpel Surgery; (CL) Control-Laser (diode laser 810 nm/1.5 W) Surgery; and (AL) Anticoagulated-Laser Surgery (diode laser 810 nm/1.5 W). Warfarin administration was used to induce anticoagulation. Blood was blotted every 30 seconds with filter paper until bleeding stopped to verify bleeding time. Two blinded researchers performed the surgeries and collected the bleeding time data. Diode laser surgery led to complete hemostasis in rats during and after lingual frenectomy. Zero bleeding was assessed during surgeries and after diode laser surgeries in anticoagulated rats. Laser-induced hemostasis offered an alternative solution to the controversial issue of intraoperative and postoperative bleeding control in patients on anticoagulation therapy.
DOI: 10.6084/m9.figshare.6503390.v1
title: Immediate laser-induced hemostasis in anticoagulated rats subjected to oral soft tissue surgery: a double-blind study

description: Abstract Given the growing trend towards medical indications for continuous use of anticoagulants, the number of patients on these medications continues to rise. The management of patients on oral anticoagulants requiring oral surgical procedures has aroused much controversy. Changes in an anticoagulation regimen are associated with an increased risk of thromboembolism. However, it seems logical and advantageous for the patients’ health if surgery could be performed without any change to the anticoagulation therapy. In dentistry, high-power lasers have been poorly explored in this field. The hemostatic properties of high-power lasers could be helpful during oral soft tissue surgeries in anticoagulated patients. The aim of this study was to compare bleeding time in anticoagulated rats after lingual frenectomy performed with a scalpel or diode laser with bleeding time in healthy animals. Twenty-four male Wistar rats were assigned to four groups (n = 6): (CS) Control-Scalpel Surgery; (AS) Anticoagulated-Scalpel Surgery; (CL) Control-Laser (diode laser 810 nm/1.5 W) Surgery; and (AL) Anticoagulated-Laser Surgery (diode laser 810 nm/1.5 W). Warfarin administration was used to induce anticoagulation. Blood was blotted every 30 seconds with filter paper until bleeding stopped to verify bleeding time. Two blinded researchers performed the surgeries and collected the bleeding time data. Diode laser surgery led to complete hemostasis in rats during and after lingual frenectomy. Zero bleeding was assessed during surgeries and after diode laser surgeries in anticoagulated rats. Laser-induced hemostasis offered an alternative solution to the controversial issue of intraoperative and postoperative bleeding control in patients on anticoagulation therapy.
DOI: 10.6084/m9.figshare.6503384
title: MULTICOMPONENT TRAINING TO IMPROVE THE FUNCTIONAL FITNESS AND GLYCEMIC CONTROL OF SENIORS WITH TYPE 2 DIABETES

description: ABSTRACT Type 2 diabetes mellitus (T2DM) is a prevalent disease in older adults and associated with functional impairment and abnormalities of the glycemic metabolism. Multicomponent training, which consists of strength, balance, coordination, gait, agility and proprioception exercises, is recommended to improve the physical function of the elderly, but its effects in the treatment of T2DM are not clear. The main goal was to investigate the effect of a multicomponent training protocol on functional and glycemic parameters in seniors with T2DM. Thirteen older adults (68±6 years) with T2DM were included. Before and after the intervention period, the following tests were performed: chair stand, arm curl, sit and reach, six-minute walk test (6MWT), fasting blood glucose and glycated hemoglobin (HbA1C). The training program was conducted for 16 weeks, three times a week, on nonconsecutive days. Each session consisted of 10 minutes of warm-up, 50 minutes of multicomponent exercises (coordination, muscle strength, flexibility, balance and agility) and 10 minutes of stretching and relaxation. Statistical analysis was performed using paired t-test and the Wilcoxon test (p&lt;0.05). Training induced an improvement in the arm curl (p = 0.001), sit and reach (p = 0.004), 6MWT (p = 0.009) and HbA1C (p = 0.01) tests. In conclusion, the multicomponent training protocol improved functional fitness and glycemic control in seniors with T2DM. However, fasting blood glucose levels and muscle strength of the lower limbs remained unchanged
DOI: 10.6084/m9.figshare.6503384.v1
title: MULTICOMPONENT TRAINING TO IMPROVE THE FUNCTIONAL FITNESS AND GLYCEMIC CONTROL OF SENIORS WITH TYPE 2 DIABETES

description: ABSTRACT Type 2 diabetes mellitus (T2DM) is a prevalent disease in older adults and associated with functional impairment and abnormalities of the glycemic metabolism. Multicomponent training, which consists of strength, balance, coordination, gait, agility and proprioception exercises, is recommended to improve the physical function of the elderly, but its effects in the treatment of T2DM are not clear. The main goal was to investigate the effect of a multicomponent training protocol on functional and glycemic parameters in seniors with T2DM. Thirteen older adults (68±6 years) with T2DM were included. Before and after the intervention period, the following tests were performed: chair stand, arm curl, sit and reach, six-minute walk test (6MWT), fasting blood glucose and glycated hemoglobin (HbA1C). The training program was conducted for 16 weeks, three times a week, on nonconsecutive days. Each session consisted of 10 minutes of warm-up, 50 minutes of multicomponent exercises (coordination, muscle strength, flexibility, balance and agility) and 10 minutes of stretching and relaxation. Statistical analysis was performed using paired t-test and the Wilcoxon test (p&lt;0.05). Training induced an improvement in the arm curl (p = 0.001), sit and reach (p = 0.004), 6MWT (p = 0.009) and HbA1C (p = 0.01) tests. In conclusion, the multicomponent training protocol improved functional fitness and glycemic control in seniors with T2DM. However, fasting blood glucose levels and muscle strength of the lower limbs remained unchanged
DOI: 10.6084/m9.figshare.6503378
title: Homogenization of a Continuously Microperiodic Multidimensional Medium

description: ABSTRACT The asymptotic homogenization method is applied to obtain formal asymptotic solution and the homogenized solution of a Dirichlet boundary-value problem for an elliptic equation with rapidly oscillating coefficients. The proximity of the formal asymptotic solution and the homogenized solution to the exact solution is proved, which provides the mathematical justification of the homogenization process. Preservation of the symmetry and positive-definiteness of the effective coefficient in the homogenized problem is also proved. An example is presented in order to illustrate the theoretical results.
DOI: 10.6084/m9.figshare.6503378.v1
title: Homogenization of a Continuously Microperiodic Multidimensional Medium

description: ABSTRACT The asymptotic homogenization method is applied to obtain formal asymptotic solution and the homogenized solution of a Dirichlet boundary-value problem for an elliptic equation with rapidly oscillating coefficients. The proximity of the formal asymptotic solution and the homogenized solution to the exact solution is proved, which provides the mathematical justification of the homogenization process. Preservation of the symmetry and positive-definiteness of the effective coefficient in the homogenized problem is also proved. An example is presented in order to illustrate the theoretical results.
DOI: 10.6084/m9.figshare.6503375
title: Fatigue strength of several dental ceramics indicated for CAD-CAM monolithic restorations

description: Abstract This in vitro study evaluated the fatigue strength of different ceramic materials indicated for monolithic restorations. Disc-shaped specimens were made according to ISO 6872 from five different ceramic materials: feldspathic ceramic (FC), polymer-infiltrated ceramic network (PIC), lithium disilicate glass-ceramic (LD), zirconia-reinforced lithium silicate glass-ceramic (ZLS), and high translucent tetragonal zirconia polycrystals doped by yttrium (YZ-HT). After obtaining the mean of each material (n = 5) from monotonic load-to-failure tests, specimens (n = 20) were subjected to fatigue tests (staircase method) using a biaxial flexural setup (piston-on-three-balls), to determine the fatigue strength. The parameters used for fatigue tests were: 100,000 cycles at 10 Hz, initial load of ~ 60% of mean load-to-failure, and step size of 5% of the initial load (specific for each ceramic material). Kruskal-Wallis and Bonferroni’s test (α = 0.05) were used to analyze the fatigue strength data. Fatigue strength (MPa) of the materials was statistically different among each other as follows: YZ-HT (370.2 ± 38.7) &gt; LD (175.2 ± 7.5) &gt; ZLS (152.1 ± 7.5) &gt; PIC (81.8 ± 3.9) &gt; FC (50.8 ± 1.9). Thus, it can be concluded that, in terms of fatigue, high translucent polycrystalline zirconia is the best choice for monolithic restorations as it bears the highest load before cracking/fracturing.