cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31204261.v1
title: Supplementary Material for: Cardiovascular Adverse Events of JAK vs. TNF Inhibitors using the Korean Pharmacovigilance Database

description: Introduction
Janus kinase inhibitors (JAK-Is), as novel medications, are utilized in treating immune-mediated inflammatory diseases such as rheumatoid arthritis. However, concerns about their cardiovascular safety associated with the use of JAK inhibitors have been increasing in recent years. This study aimed to compare the risk of cardiovascular events (CVEs) in patients taking JAK-Is and tumor necrosis factor alpha inhibitors (TNF-Is) using the Korea Adverse Event Reporting System (KAERS) database.

Methods
Adverse event (AE) reports between January 1, 2015 and December 31, 2020 of JAK-Is (tofacitinib or baricitinib) or TNF-Is (adalimumab, etanercept, or golimumab) were included. CVEs were categorized into major cardiovascular events (MACEs), thrombosis, and other CVEs. The reporting odds ratios (RORs) for outcomes with 95% confidence interval (CIs) were calculated using 2x2 contingency tables. 

Results
A total of 625 AE reports were identified for JAK-I and 4,777 for TNF-Is, resulting in 876 and 7,999 drug-AE pairs, respectively. Disproportionality analysis showed reporting signals suggesting possible associations between JAK-Is and CVEs compared with TNF-Is (ROR: 4.90, 95% CI: 2.80–8.59), with particularly pronounced for thrombosis (ROR: 12.70, 95% CI: 5.10–31.66). These trends were particularly notable in women (CVEs: ROR: 7.52, 95% CI: 3.06-18.47) and in patients over 50 years old (CVEs: ROR: 5.01, 95% CI: 2.02-12.43).

Conclusion
This disproportionality analysis using a national pharmacovigilance database identified reporting signals for total CVEs with JAK-Is compared to TNF-Is; in particular, a significant signal for thrombosis was observed.
DOI: 10.6084/m9.figshare.31204264
title: Supplementary Material for: What is the optimal endoscopic resection method for intermediate-sized (10–20 mm) superficial non-ampullary duodenal epithelial tumors? A Systematic review

description: Background:
For intermediate-sized (10–20 mm) superficial non-ampullary duodenal epithelial tumors (SNADETs), various endoscopic resection (ER) techniques are available, including conventional endoscopic mucosal resection (EMR), underwater EMR (UEMR), and endoscopic submucosal dissection (ESD). However, the optimal method remains uncertain.
Summary:
We conducted a systematic review of studies published from January 2013 to August 2023 using PubMed and the Japan Medical Abstracts Society database. Eligible studies reported ER outcomes for SNADETs of ≤20 mm. Data were extracted from 14 cohort studies (3 multicenter of lesions 10-20 mm in size and 11 single-center of lesions less than 20 mm), including en bloc and R0 resection rates, delayed bleeding, intraoperative and delayed perforation, and recurrence. In the multicenter studies, the pooled en bloc resection rates for EMR, UEMR, and ESD of intermediate-sized SNADETs were 82.7%, 74.8%, and 94.6%, respectively. The corresponding R0 resection rates were 54.2%, 50.6%, and 80.9%. Delayed bleeding rates were similar across methods (3.3% for EMR, 3.2% for UEMR, and 5.4% for ESD). However, intraoperative and delayed perforation were more frequent with ESD (7.9% and 3.0%) than with EMR (1.1% and 0.3%) and UEMR (0.0% and 0.0%). Single-center studies showed consistent trends, with ESD achieving higher resection rates but also showing greater variability in adverse events. Recurrence rates were about 5% for EMR and UEMR, with no recurrences reported after ESD.
Key messages:
While ESD provides superior resection quality, EMR and UEMR offer favorable outcomes with fewer adverse events. Given their safety and efficacy profiles, EMR and UEMR should be considered appropriate first-line treatment options for intermediate-sized SNADETs.
DOI: 10.6084/m9.figshare.31204264.v1
title: Supplementary Material for: What is the optimal endoscopic resection method for intermediate-sized (10–20 mm) superficial non-ampullary duodenal epithelial tumors? A Systematic review

description: Background:
For intermediate-sized (10–20 mm) superficial non-ampullary duodenal epithelial tumors (SNADETs), various endoscopic resection (ER) techniques are available, including conventional endoscopic mucosal resection (EMR), underwater EMR (UEMR), and endoscopic submucosal dissection (ESD). However, the optimal method remains uncertain.
Summary:
We conducted a systematic review of studies published from January 2013 to August 2023 using PubMed and the Japan Medical Abstracts Society database. Eligible studies reported ER outcomes for SNADETs of ≤20 mm. Data were extracted from 14 cohort studies (3 multicenter of lesions 10-20 mm in size and 11 single-center of lesions less than 20 mm), including en bloc and R0 resection rates, delayed bleeding, intraoperative and delayed perforation, and recurrence. In the multicenter studies, the pooled en bloc resection rates for EMR, UEMR, and ESD of intermediate-sized SNADETs were 82.7%, 74.8%, and 94.6%, respectively. The corresponding R0 resection rates were 54.2%, 50.6%, and 80.9%. Delayed bleeding rates were similar across methods (3.3% for EMR, 3.2% for UEMR, and 5.4% for ESD). However, intraoperative and delayed perforation were more frequent with ESD (7.9% and 3.0%) than with EMR (1.1% and 0.3%) and UEMR (0.0% and 0.0%). Single-center studies showed consistent trends, with ESD achieving higher resection rates but also showing greater variability in adverse events. Recurrence rates were about 5% for EMR and UEMR, with no recurrences reported after ESD.
Key messages:
While ESD provides superior resection quality, EMR and UEMR offer favorable outcomes with fewer adverse events. Given their safety and efficacy profiles, EMR and UEMR should be considered appropriate first-line treatment options for intermediate-sized SNADETs.
DOI: 10.6084/m9.figshare.31204267
title: Supplementary Material for: High Pressure Water Jet Ocular Injuries during Riot Control – A Case series

description: Purpose: To describe various ocular injuries caused by water jets, with a particular emphasis on injuries inflicted by water cannon vehicles used during riots. 
Design: A retrospective observational case series
Methods: We report a case series of eleven eyes of nine patients injured form a direct high pressure water jet used by the police in Israel as a riot control measure during a demonstration. All patients admitted to the emergency room with blunt ocular trauma had undergone clinical examination by an ophthalmologist. 
Results: Hyphema was the most common ocular injury observed, affecting 8 out of the 11 eyes examined, followed by traumatic mydriasis and vitreous hemorrhage in 54% and 36% of patients, respectively. In this series two of nine patients required ocular surgery. Injuries requiring surgical intervention were retinal detachment, lens dislocation and vitreous hemorrhage.
Conclusions: Water-jet injuries may inflict severe damage to the globe and orbital structures. Care should be taken preventing such injuries inflicted by water cannon vehicles used during riots.
DOI: 10.6084/m9.figshare.31204267.v1
title: Supplementary Material for: High Pressure Water Jet Ocular Injuries during Riot Control – A Case series

description: Purpose: To describe various ocular injuries caused by water jets, with a particular emphasis on injuries inflicted by water cannon vehicles used during riots. 
Design: A retrospective observational case series
Methods: We report a case series of eleven eyes of nine patients injured form a direct high pressure water jet used by the police in Israel as a riot control measure during a demonstration. All patients admitted to the emergency room with blunt ocular trauma had undergone clinical examination by an ophthalmologist. 
Results: Hyphema was the most common ocular injury observed, affecting 8 out of the 11 eyes examined, followed by traumatic mydriasis and vitreous hemorrhage in 54% and 36% of patients, respectively. In this series two of nine patients required ocular surgery. Injuries requiring surgical intervention were retinal detachment, lens dislocation and vitreous hemorrhage.
Conclusions: Water-jet injuries may inflict severe damage to the globe and orbital structures. Care should be taken preventing such injuries inflicted by water cannon vehicles used during riots.
DOI: 10.6084/m9.figshare.31204270
title: Supplementary Material for: The CrescNet Registry Achondroplasia Module: Real-World Demographic Data and Clinical Outcomes in Untreated and Vosoritide-Treated Individuals

description: Introduction: Achondroplasia is a rare skeletal dysplasia characterized by severe disproportionate short stature. Vosoritide is currently the only approved therapy. The CrescNet registry is a network of primary and specialized pediatric tertiary centers that aims to improve early detection of growth disorders in Europe. In 2021, an achondroplasia-specific data collection module was set up within CrescNet to enhance data collection among children with achondroplasia and assess the impact of interventions. Here, we describe the module setup and report preliminary real-world outcomes of vosoritide treatment over 3 years.

Methods: The module was established in 10 of 11 countries participating in CrescNet. Achondroplasia-specific data were collected, including developmental milestones, interventions (such as limb-lengthening surgery, treatment with vosoritide and growth hormone), complications, and health-related quality of life, alongside standard anthropometric measurements (eg height, weight, etc). Pseudonymized data were sent to the CrescNet central database, Leipzig University Hospital, Germany, for analysis by age and treatment status.

Results: As of May 2025, 486 participants from 32 tertiary centers were enrolled. Data from 73 untreated and 186 vosoritide-treated individuals with genetically documented achondroplasia were analyzed. In vosoritide-treated individuals, mean height standard deviation score, referenced to an untreated European achondroplasia population, significantly increased from baseline at 1, 2, and 3 years after vosoritide initiation (P≤0.0001).

Conclusions: The module facilitates the collection of real-world data to improve understanding of the natural history of achondroplasia and outcomes associated with interventions. Growth data from vosoritide-treated individuals were consistent with clinical trial findings and published real-world data. Longer-term follow-up is ongoing.
DOI: 10.6084/m9.figshare.31204270.v1
title: Supplementary Material for: The CrescNet Registry Achondroplasia Module: Real-World Demographic Data and Clinical Outcomes in Untreated and Vosoritide-Treated Individuals

description: Introduction: Achondroplasia is a rare skeletal dysplasia characterized by severe disproportionate short stature. Vosoritide is currently the only approved therapy. The CrescNet registry is a network of primary and specialized pediatric tertiary centers that aims to improve early detection of growth disorders in Europe. In 2021, an achondroplasia-specific data collection module was set up within CrescNet to enhance data collection among children with achondroplasia and assess the impact of interventions. Here, we describe the module setup and report preliminary real-world outcomes of vosoritide treatment over 3 years.

Methods: The module was established in 10 of 11 countries participating in CrescNet. Achondroplasia-specific data were collected, including developmental milestones, interventions (such as limb-lengthening surgery, treatment with vosoritide and growth hormone), complications, and health-related quality of life, alongside standard anthropometric measurements (eg height, weight, etc). Pseudonymized data were sent to the CrescNet central database, Leipzig University Hospital, Germany, for analysis by age and treatment status.

Results: As of May 2025, 486 participants from 32 tertiary centers were enrolled. Data from 73 untreated and 186 vosoritide-treated individuals with genetically documented achondroplasia were analyzed. In vosoritide-treated individuals, mean height standard deviation score, referenced to an untreated European achondroplasia population, significantly increased from baseline at 1, 2, and 3 years after vosoritide initiation (P≤0.0001).

Conclusions: The module facilitates the collection of real-world data to improve understanding of the natural history of achondroplasia and outcomes associated with interventions. Growth data from vosoritide-treated individuals were consistent with clinical trial findings and published real-world data. Longer-term follow-up is ongoing.
DOI: 10.6084/m9.figshare.31204273
title: Supplementary Material for: Long-term outcomes in patients with renal systemic light chain amyloidosis

description: Introduction: Studies on the long-term outcomes of patients with predominant renal involvement and no significant extra-renal organ involvement in systemic light chain (AL) amyloidosis remain limited. Here we describe the outcomes of this population and examine the impact of the one year estimated glomerular filtration rate (eGFR) changes on mortality and renal survival.
Methods：Patients with predominant renal involvement in AL amyloidosis who were diagnosed at National Clinical Research Center for Kidney Diseases of Jinling Hospital between 2010 and 2023 were included in this study. Medical records and follow-up data were collected. The primary endpoints, encompassing overall survival (OS) and renal survival, were analyzed using Kaplan-Meier and Cox regression.
Results：A total of 351 patients (median age 56, range 31-83; 53.3% male) were enrolled, with 86.9% having an eGFR &gt; 60 mL/min/1.73 m2 and median 24-hour proteinuria of 4.27 g/d. After a median follow-up of 60 months (range, 3-171 months), 65 patients (18.5%) were died and 60 (17.1%) had progressed to end-stage renal disease. The median OS was not reached, and the median renal survival was 157 months. The five-year OS and renal survival were 83.7% and 86.5%, respectively. Patients achieving at least a hematological and renal very good partial response exhibit significantly better outcomes. Within the first year, an eGFR decline of ≥5 mL/min/1.73m² (particularly ≥20 mL/min/1.73m2) was associated with increased dialysis risk, while a decline of ≥20 mL/min/1.73m2 was independently linked to elevated mortality risk.
Conclusion：AL amyloidosis patients with predominant renal involvement have a relatively good prognosis and early eGFR decline has the potential value in prognostic assessment of renal AL amyloidosis.
DOI: 10.6084/m9.figshare.31204273.v1
title: Supplementary Material for: Long-term outcomes in patients with renal systemic light chain amyloidosis

description: Introduction: Studies on the long-term outcomes of patients with predominant renal involvement and no significant extra-renal organ involvement in systemic light chain (AL) amyloidosis remain limited. Here we describe the outcomes of this population and examine the impact of the one year estimated glomerular filtration rate (eGFR) changes on mortality and renal survival.
Methods：Patients with predominant renal involvement in AL amyloidosis who were diagnosed at National Clinical Research Center for Kidney Diseases of Jinling Hospital between 2010 and 2023 were included in this study. Medical records and follow-up data were collected. The primary endpoints, encompassing overall survival (OS) and renal survival, were analyzed using Kaplan-Meier and Cox regression.
Results：A total of 351 patients (median age 56, range 31-83; 53.3% male) were enrolled, with 86.9% having an eGFR &gt; 60 mL/min/1.73 m2 and median 24-hour proteinuria of 4.27 g/d. After a median follow-up of 60 months (range, 3-171 months), 65 patients (18.5%) were died and 60 (17.1%) had progressed to end-stage renal disease. The median OS was not reached, and the median renal survival was 157 months. The five-year OS and renal survival were 83.7% and 86.5%, respectively. Patients achieving at least a hematological and renal very good partial response exhibit significantly better outcomes. Within the first year, an eGFR decline of ≥5 mL/min/1.73m² (particularly ≥20 mL/min/1.73m2) was associated with increased dialysis risk, while a decline of ≥20 mL/min/1.73m2 was independently linked to elevated mortality risk.
Conclusion：AL amyloidosis patients with predominant renal involvement have a relatively good prognosis and early eGFR decline has the potential value in prognostic assessment of renal AL amyloidosis.
DOI: 10.6084/m9.figshare.31204276
title: Supplementary Material for: Feasibility and safety of a robotic-assisted optical navigation system for pulmonary nodule percutaneous cryoablation: a prospective, single-center, single-arm pilot study

description: Background: Percutaneous cryoablation under imaging guidance is an effective therapeutic modality for pulmonary nodules, but the conventional technique relies on surgical complexity and physician experience. Computed tomography (CT)-guided robotic-assisted percutaneous puncture technique provides three-dimensional (3D) reconstruction, optimal needle trajectory planning, and monitoring of real-time respiratory motion, thereby enabling safe ablation of lung nodules. This study aimed to clinically evaluate the feasibility and safety of a robotic-assisted optical navigation system when utilized for CT-guided percutaneous cryoablation of pulmonary nodules.
Methods: Patients who underwent CT-guided percutaneous cryoablation via a robotic-assisted optical navigation system were prospectively enrolled in our study. The primary outcomes were the technical success rate and the technical efficacy rate, and the preoperative, intraoperative, and postoperative variables were recorded and analyzed for each patient.
Results: A total of 37 consecutive patients with a single nodule were ultimately enrolled in the present study. The technical success rate was 100%, and the technical efficacy rate of robotic-assisted cryoablation was 100% with no recurrence during the 1-month follow-up. The average number of needle adjustments per nodule was 0.82 ± 1.19 in this study, with a mean deviation of 3.47 ± 2.47 mm. The mean numbers of CT acquisitions and dose length product (DLP) used during needle insertion were 3.44 ± 1.65 and 638.86 ± 434.44 mGy•cm, respectively. The duration of needle placement was 15.95 ± 5.06 min, whereas the total procedural duration was 99.32 ± 32.00 min. Notably, the deviation was found to be significantly correlated with the lobar location and was more prominent in the lower lobe. However, no significant correlations were observed with the nodule type, size, distance to the pleura, chest wall thickness, needle trajectory length, decubitus position, or the pulmonary function status of the patient. Moreover, no significant changes were found in the pulmonary function of the patients before or after the treatment. No major grade ≥3 complications were observed. However, among the minor complications, there were 5 cases (13.51%) of immediate pneumothorax, 2 cases (5.41%) of delayed pneumothorax, and 1 case (2.70%) of hemorrhage. 
Conclusion: The feasibility, safety, and preliminary effectiveness of robotic-assisted optical navigation system for CT-guided percutaneous cryoablation of pulmonary nodules were demonstrated; however, long-term efficacy and safety require further validation through multicenter, large-scale, prospective clinical studies with extended follow-up.
DOI: 10.6084/m9.figshare.31204276.v1
title: Supplementary Material for: Feasibility and safety of a robotic-assisted optical navigation system for pulmonary nodule percutaneous cryoablation: a prospective, single-center, single-arm pilot study

description: Background: Percutaneous cryoablation under imaging guidance is an effective therapeutic modality for pulmonary nodules, but the conventional technique relies on surgical complexity and physician experience. Computed tomography (CT)-guided robotic-assisted percutaneous puncture technique provides three-dimensional (3D) reconstruction, optimal needle trajectory planning, and monitoring of real-time respiratory motion, thereby enabling safe ablation of lung nodules. This study aimed to clinically evaluate the feasibility and safety of a robotic-assisted optical navigation system when utilized for CT-guided percutaneous cryoablation of pulmonary nodules.
Methods: Patients who underwent CT-guided percutaneous cryoablation via a robotic-assisted optical navigation system were prospectively enrolled in our study. The primary outcomes were the technical success rate and the technical efficacy rate, and the preoperative, intraoperative, and postoperative variables were recorded and analyzed for each patient.
Results: A total of 37 consecutive patients with a single nodule were ultimately enrolled in the present study. The technical success rate was 100%, and the technical efficacy rate of robotic-assisted cryoablation was 100% with no recurrence during the 1-month follow-up. The average number of needle adjustments per nodule was 0.82 ± 1.19 in this study, with a mean deviation of 3.47 ± 2.47 mm. The mean numbers of CT acquisitions and dose length product (DLP) used during needle insertion were 3.44 ± 1.65 and 638.86 ± 434.44 mGy•cm, respectively. The duration of needle placement was 15.95 ± 5.06 min, whereas the total procedural duration was 99.32 ± 32.00 min. Notably, the deviation was found to be significantly correlated with the lobar location and was more prominent in the lower lobe. However, no significant correlations were observed with the nodule type, size, distance to the pleura, chest wall thickness, needle trajectory length, decubitus position, or the pulmonary function status of the patient. Moreover, no significant changes were found in the pulmonary function of the patients before or after the treatment. No major grade ≥3 complications were observed. However, among the minor complications, there were 5 cases (13.51%) of immediate pneumothorax, 2 cases (5.41%) of delayed pneumothorax, and 1 case (2.70%) of hemorrhage. 
Conclusion: The feasibility, safety, and preliminary effectiveness of robotic-assisted optical navigation system for CT-guided percutaneous cryoablation of pulmonary nodules were demonstrated; however, long-term efficacy and safety require further validation through multicenter, large-scale, prospective clinical studies with extended follow-up.
DOI: 10.15468/dl.sfub4p
title: Occurrence Download

description: A dataset containing 174 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Nerisyrenia linearifolia",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 174 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001584-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/14673667
title: LUFlow Network Intrusion Detection Data Set
DOI: 10.15468/dl.2bgbfq
title: Occurrence Download

description: A dataset containing 9244 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Cymodocea rotundata",
 "Year 1990-2026"
 ]
}

 The dataset includes 9244 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001587-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.58tdkh
title: Occurrence Download

description: A dataset containing 36096 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Parthenium hysterophorus"
 ]
}

 The dataset includes 36096 records from 500 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001589-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.