DOI: 10.6084/m9.figshare.20592177
title: Is increased chronological age a contraindication to debulking surgery for elderly patients with advanced ovarian cancer?

description: We collected data of elderly patients aged 65 years and older who underwent debulking surgery for advanced ovarian cancer in order to explore the impact of old age on surgical outcomes and complications. A total of 120 patients were classified as follows: group 1, 65–69 years (<i>n</i> = 58); group 2, 70–74 years (<i>n</i> = 38); group 3, 75–79 years (<i>n</i> = 17); group 4, ≥80 years (<i>n</i> = 7). There were no differences in most of the characteristics, surgical extent and outcomes, and postoperative complications between the four groups, whereas polypharmacy was more common (6 vs. 5–16; <i>p</i>=.02) and operation time was shorter (median, 194 vs. 285–330 min; <i>p</i>=.02) in group 4. Factors related to frailty rather than age, polypharmacy, preoperative albumin level, estimated blood loss and transfusion increased the risk of postoperative complications. Thus, the impact of old age on surgical extent, outcomes and postoperative complications may be minimal in elderly patients with advanced ovarian cancer.
Impact Statement<b>What is already known on this subject?</b> Optimal debulking surgery is a significant factor in improving the prognosis of ovarian cancer but it is not easy to perform such radical surgery on elderly patients in fear of increasing surgical morbidity and mortality. Some studies suggest that underlying comorbidities may be a stronger contributing factor to increasing such risk rather than old age although there is not enough evidence yet.<b>What do the results of this study add?</b> Through this study, we could see that increased age is not the determining cause of increased morbidity and mortality in elderly patients who undergo optimal debulking surgery in ovarian cancer. There are other aspects describing a patient’s health status that can predict prognosis better rather than age.<b>What are the implications of these findings for clinical practice and/or further research?</b> Old age need not be a contraindication when performing optimal debulking surgery in elderly patients with advanced ovarian cancer. <b>What is already known on this subject?</b> Optimal debulking surgery is a significant factor in improving the prognosis of ovarian cancer but it is not easy to perform such radical surgery on elderly patients in fear of increasing surgical morbidity and mortality. Some studies suggest that underlying comorbidities may be a stronger contributing factor to increasing such risk rather than old age although there is not enough evidence yet. <b>What do the results of this study add?</b> Through this study, we could see that increased age is not the determining cause of increased morbidity and mortality in elderly patients who undergo optimal debulking surgery in ovarian cancer. There are other aspects describing a patient’s health status that can predict prognosis better rather than age. <b>What are the implications of these findings for clinical practice and/or further research?</b> Old age need not be a contraindication when performing optimal debulking surgery in elderly patients with advanced ovarian cancer.