cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5277724.v1
title: Table S4 from Coevolution in the timing of GABAergic and pyramidal neuron maturation in primates

description: The cortex of primates is relatively expanded relative to many other mammals, yet little is known about what developmental processes account for the expansion of cortical subtype numbers in primates, including humans. We asked whether GABAergic and pyramidal neuron production occurs for longer than expected in primates than in mice in a sample of 86 developing primate and rodent brains. We use high-resolution structural, diffusion MR scans and histological material to compare the timing of the ganglionic eminences (GE) and cortical proliferative pool (CPP) maturation between humans, macaques, rats and mice. We also compare the timing of post-neurogenetic maturation of GABAergic and pyramidal neurons in primates (i.e. humans, macaques) relative to rats and mice to identify whether delays in neurogenesis are concomitant with delayed post-neurogenetic maturation. We found that the growth of the GE and CPP are both selectively delayed compared with other events in primates. By contrast, the timing of post-neurogenetic GABAergic and pyramidal events (e.g. synaptogenesis) are predictable from the timing of other events in primates and in studied rodents. The extended duration of GABAergic and pyramidal neuron production is associated with the amplification of GABAerigc and pyramidal neuron numbers in the human and non-human primate cortex.
DOI: 10.6084/m9.figshare.21840327.v1
title: Supplementary Material for: Evaluation of a novel combination therapy, based on trifluridine/tipiracil and fruquintinib, against colorectal cancer

description: Introduction: Trifluridine/tipiracil hydrochloride (FTD/TPI, Lonsurf®) is an oral antineoplastic agent that has been approved as a late-stage chemotherapy for colorectal cancer. Its major mechanism of action is the dysfunction of tumoral DNA including DNA strand breaks and decreased replication. Fruquintinib (ELUNATE®) is a novel kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-1, -2, and -3. In this study, we evaluated the antitumor activity of combination therapy with FTD/TPI and fruquintinib in vivo. Methods: The enhancement of the antitumor effects with FTD/TPI and fruquintinib combination, compared to the single drugs given alone was evaluated using two human colorectal cancer xenografts in nude mouse models. FTD/TPI (200 mg/kg) was orally administered for 5 consecutive days followed by 2 days of rest in a 7-day period. Fruquintinib (10 mg/kg) was orally administered consecutively for 2 and 3 weeks in SW48 and HCT 116 tumor-bearing models, respectively. After treatment with these agents, the microvessel density was evaluated by CD31 immunohistochemical analyses. Results: In both models, FTD/TPI and fruquintinib significantly inhibited tumor growth, and the activity of the combined treatment was significantly superior to that of either monotherapy. Body weight loss of greater than 20% was not observed in any group. A histochemical analysis showed nuclei enlargement, abnormal mitosis and karyorrhexis in the FTD/TPI treatment group. The microvessel density in the HCT 116 tumors treated with FTD/TPI and fruquintinib was significantly lower than that in the control group. Conclusion: The combination of FTD/TPI and fruquintinib could be a promising treatment option for colorectal cancer.
DOI: 10.6084/m9.figshare.26198549.v1
title: Supplementary Table 1.xlsx

description: gene
DOI: 10.17632/nt6dm9j7dw
title: Response of watershed sediment yield to rainfall and vegetation cover in the northern of Chinese Loess Plateau during the implementing of “Grain for Green” project

description: This dataset was used to study the cyclical changes in rainfall before and after the “Grain for Green” project in the northern Loess Plateau of China, and the coupling relationship between sediment yield in the watershed on annual rainfall and vegetation coverage over the past 20 years.
The watershed selected for the study is located in the Yulin area of Shaanxi Province, China, close to the Mao Wusu Desert, with soils containing large amounts of coarse sand particles, and annual rainfall is much lower than that of the central Loess Plateau, where regional droughts and heavy rainfall events are frequent. The study obtained the sediment yield under individual rainfall conditions by excavating sediment profiles at the outlet check dam of the watershed, combined with satellite remote sensing data.
DOI: 10.6084/m9.figshare.23904669.v1
title: Supplementary Material for: Evaluation the Impact of Obesity and Different Metabolic Status on the Prognosis of Hospitalized Patients with Inflammatory Bowel Disease: A Cohort Study.

description: Introduction: Obesity is associated with an increased risk of inflammatory bowel disease (IBD), whereas not all obesity individuals have the same effect. In individuals with obesity, the role of metabolic status in the readmission of IBD remains unclear. Our study aimed to evaluate the association between different obesity metabolic phenotypes and the prognosis of IBD patients. Methods: We conducted a longitudinal cohort study using Nationwide Readmission Database (2018 sample). Out of 12,928,231 discharge records, 63,748 records with a discharge diagnosis of IBD were identified for analysis. Cox proportional hazard ratio (HR) with 95% confidence interval (CI) was calculated adjusting for potential confounders. Results: During 180-day follow-up in IBD patients with different obesity metabolic phenotypes, all-cause readmission rate, inpatient mortality rate, unplanned readmission rate, total charge, hospitalized length of stay were statistical different (all P&lt;0.001). After multivariate Cox regression analysis, IBD patients with metabolically unhealthy nonobese (MUNO) had higher risk of readmission (all-cause and unplanned) (HR 1.04, 95% CI 1.00-1.08 and HR 1.06, 95% CI 1.02-1.10), and that with metabolically unhealthy obesity (MUO) had higher risk of unplanned readmission (HR 1.08, 95% CI 1.02-1.15). In subgroup analysis, both MUNO group and MUO group had higher risk of readmission (all-cause and unplanned) in UC subgroup; but only MUNO group had higher risk of readmission (all-cause and unplanned) (HR 1.05, 95% CI 1.00-1.10 and HR 1.06, 95%CI 1.01-1.12) in CD subgroup. Conclusion: Metabolic abnormalities were associated with an increased risk of readmission in patients with IBD, regardless of obesity.
DOI: 10.60893/figshare.pof.26117923.v1
title: Lookup table

description: The variation of physical function with the dimensionless temperature and pressure
DOI: 10.17632/nszt95sk4j
title: Data for: A systematic approach to quantitative Western blot analysis

description: Figures 5 and 6 have been shared for reviewers analysis.
DOI: 10.6084/m9.figshare.18318845.v1
title: Supplementary Material for: Polypharmacy and Hyperpolypharmacy in Older Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

description: <b><i>Background and Aim:</i></b> Polypharmacy (concomitant use of 5–9 medicines) and hyperpolypharmacy (concomitant use of over 10 medicines) were observed to be more frequent in older adults (≥65 years) and associated with adverse outcomes. Their prevalence and risk in older patients with Parkinson’s disease (PD) remain unknown. We aimed to synthesize the extant evidence on the prevalence and risk of polypharmacy and hyperpolypharmacy in older adults with PD. <b><i>Methods:</i></b> A systematic literature search was performed in PubMed/MEDLINE, Scopus, and Embase databases to identify pertinent studies published from 2000 to July 2021. Observational studies reporting the prevalence and association with disease of polypharmacy/hyperpolypharmacy in older adults with PD were meta-analyzed. Pooled prevalence and odds ratio (OR) with 95% confidence intervals (CIs) were calculated. <b><i>Results:</i></b> Out of the total 499 studies identified, 6 fulfilled the inclusion criteria and comprised 7,171 participants. The overall prevalence of polypharmacy and hyperpolypharmacy was 40% (95% CI: 37–44) and 18% (95% CI: 13–23), respectively. A meta-analysis of 4 studies indicated a significant association between polypharmacy (OR: 1.94, 95% CI: 1.26–2.62; <i>p</i> &lt; 0.001) and PD. Hyperpolypharmacy was also strongly associated with PD (OR: 3.11, 95% CI: 2.08–4.14; <i>p</i> &lt; 0.001). <b><i>Conclusion:</i></b> Polypharmacy (40%) and hyperpolypharmacy (18%) are highly prevalent and eventually increase the risk of drug-related problems in older adults with PD. Therefore, interventions that ensure rational geriatric pharmacotherapy are of critical importance for the older population with neurogenerative disorders.
DOI: 10.6084/m9.figshare.27902073.v1
title: Metab-Metab Interaction Table

description: Metab-Metab Interaction Table
DOI: 10.6084/m9.figshare.5769144.v2
title: Illustrations of flowers and pollinators

description: The illustrations of flower and pollinator species.
DOI: 10.6084/m9.figshare.26968609.v1
title: Inhibitory effect of exercise on elevated blood pressure and fetal growth restriction during pregnancy in Dahl salt-sensitive rats

description: <b>Background:</b>Despite the effectiveness of exercise in preventing gestational hypertension, its mechanism remains unknown. Patients with gestational hypertension exhibit a centrally dysregulated autonomic nervous system. This study explores the effects of exercise on Dahl salt-sensitive (DSS) rats, which develop hypertension during pregnancy. Changes in gene expression within the circulatory center and placenta are investigated to clarify the mechanism underlying exercise.<b>Method:</b>DSS rats were divided into two groups: non-exercise or exercise, and Sprague-Dawley rats were used as a control. Exercise involved voluntary running using a rotating cage, starting from 4 weeks prior to pregnancy until the last trimester. Cardiovascular parameters, molecular characteristics of brain cardiovascular centers and placenta, and fetal conditions were evaluated.
DOI: 10.6084/m9.figshare.22153964.v1
title: lamb and ewe chip-data

description: Chip data of 95 sheep after filtering
DOI: 10.6084/m9.figshare.12383351.v1
title: FC and FCSS files and images for geometric morphometric analyses of Ranunculus auricomus sexuals

description: FC (flow cytometry) and ssFCSS (single-seed flow cytometric seed screening) files (*.fcs + Excel sheets) of sexual species of the Ranunculus auricomus complex.<br>Images of basal and stem leaves, and receptacles used in geometric morphometric analysis for Ranunculus auricomus. We also provided TPS file s containing landmarks. <br>
DOI: 10.6084/m9.figshare.4983368.v1
title: Menopause Study Plos One

description: Data from a clinical trial investigating the effects of red clover isoflavone aglycones on menopausal symptoms<b></b>
DOI: 10.6084/m9.figshare.21428001.v1
title: Supplementary Material for: <b><i>APOL1</i></b> G3 Variant Is Associated with Cardiovascular Mortality and Sudden Cardiac Death in Patients Receiving Maintenance Hemodialysis of European Ancestry

description: <b><i>Introduction:</i></b> The G1 and G2 variants in the <i>APOL1</i> gene convey high risk for the progression of chronic kidney disease in African Americans. The G3 variant in <i>APOL1</i> is more common in patients of European ancestry (EA); outcomes associated with this variant have not been explored previously in EA patients receiving dialysis. <b><i>Methods:</i></b> DNA was collected from approximately half of the patients enrolled in the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) trial and genotyped for the G3 variants. We utilized an additive genetic model to test associations of G3 with the EVOLVE adjudicated endpoints of all-cause mortality, cardiovascular mortality, sudden cardiac death (SCD), and heart failure. EA and African ancestry samples were analyzed separately. Validation was done in the Vanderbilt BioVU using ICD codes for cardiovascular events that parallel the adjudicated endpoints in EVOLVE. <b><i>Results:</i></b> In EVOLVE, G3 in EA patients was associated with the adjudicated endpoints of cardiovascular mortality and SCD. In a validation cohort from the Vanderbilt BioVU, cardiovascular events and cardiovascular mortality defined by ICD codes showed similar associations in EA participants who had been on dialysis for 2 to &lt;5 years. <b><i>Discussion/Conclusions:</i></b> G3 in <i>APOL1</i> variant was associated with cardiovascular events and cardiovascular mortality in the EA patients receiving dialysis. This suggests that variations in the <i>APOL1</i> gene that differ in populations of different ancestry may contribute to cardiovascular disease.
DOI: 10.6084/m9.figshare.25706589.v1
title: Scoping data table

description: Simulation is increasingly being adopted by healthcare educators throughout the developed world as it offers a safe environment to practice skills. While there is literature on learning via simulation in healthcare in the developed world, more studies are required to investigate the factors influencing this approach in the developing world.
DOI: 10.6084/m9.figshare.21791765.v1
title: Morphology Data Files

description: Datasets for the taxonomic identification of plankton by morphology. Includes: 1) raw data of taxonomy per sample site. 2) taxonomy2PercentAbundance files for Biomass and Density data summarizing taxonomy and percent relative abundance for each sample. <br>
DOI: 10.6084/m9.figshare.7545002.v2
title: Hagfish from the Cretaceous Tethys Sea and a reconciliation of the morphological–molecular conflict in early vertebrate phylogeny: Data files

description: Cladistic datasets and data files from synchrotron scanning for DOI: 10.1073/pnas.1814794116.
DOI: 10.6084/m9.figshare.21842574.v1
title: D8 - qPCR results

description: CSV file with the qPCR results. The data shown has been averaged over the technical replicates, but each biological replicate is included. The abundance was calculated from the mean cycle threshold (Ct) which was then quantified into abundance (gene copy number) using the standard curve. <br> If the target could not be detected in all of the technical replicates the sample was marked as detected but not quantifiable and was given a value of '1.1' in order that the data could be plotted. <br> The columns of the file include the following information: 'Time' shows the month and year the sample was collected. 'Location' indicates the location. "Bio_rep" is the biological replicate. 'Filter' records the filter pore size in μm (all filters tested here were 5μm). 'Abundance' is the calculated abundance. 'N' shows the number of technical replicates that the abundance was averaged across. 'Sd' is the standard deviation in the technical replicates 'se' is the standard error across the technical replicates 'Target' shows the target of the primer and probes, includes the gene and group. 'Partner' shows whether the target was host or plastid.
DOI: 10.6084/m9.figshare.27002581.v1
title: RNA-seq analysis of gluconic acid in hypertrophic scar fibroblasts

description: Hypertrophic scar fibroblasts were subjected to treatment with either gluconic acid or a distilled water control for a duration of 24 hours, conducted in triplicate. Subsequent to the treatment, cells were harvested for the preparation of transcriptome libraries and sequencing, which was performed using the Illumina NovaSeq 6000 platform in paired-end 150 mode by ShanghaiBio Corporation. Differentially expressed genes (DEGs) were identified with the application of a false discovery rate (FDR) correction. Genes exhibiting a fold change of ≥2 and a P-value of ≤0.05 between the two groups were classified as DEGs.
DOI: 10.17632/hgsf7bwkrv
title: Dataset on ore grinding and grading process

description: In ore grinding and grading process, the detectable variables mainly include ore feeding flow (FIT2003), the ore feed pressure of cyclones (PIT2001), pump sump level (LIT2004&LIT2005), ore feed concentration of cyclones (DIT2001), overflow granularity (AT2001), the overflow concentration (DIT2002), flow-rate of overflow (FIT2005), and the amount of the returning sand. The controllable variables mainly include the amount of supplementary water (FIT2004) in slime dam and the rotational speed of turning pump (ZJB2DL).
DOI: 10.6084/m9.figshare.26086594.v1
title: EF classification of schizophrenia-Data Analysis-and-Code

description: EF classification of schizophrenia-Data Analysis-and-Code
DOI: 10.6084/m9.figshare.12459749.v1
title: Shear strength database for sands

description: Shear strength database for clean sands
DOI: 10.6084/m9.figshare.26977840.v1
title: LifeCare - Data

description: Raw data from a study comparing live and recorded music for people living with dementia.
DOI: 10.17632/bzwd9fx45s
title: A dataset of multiangular spectra of tree bark for three boreal tree species

description: The collection and preprocessing of this dataset has been reported in detail in Juola J., Hovi A., Rautiainen M. (2020). Multiangular spectra of tree bark for common boreal tree species in Europe. Silva Fennica vol. 54 no. 4 article id 10331. https://doi.org/10.14214/sf.10331. 

The dataset includes average multiangular stem bark reflectance spectra of three common boreal tree species found in Europe: silver birch (Betula pendula Roth), Scots pine (Pinus sylvestris L.), and Norway spruce (Picea abies (L.) H. Karst.).  Bidirectional reflectance factors (BRF) at visible and near-infrared wavelengths (418-924 nm) are reported for each tree species. Multiangular measurements were performed in six different view angles along the principal plane (29, 58, 65, 90, 115, and 140 degrees), using a laboratory goniometer. The 90° view angle is perpendicular to the sample surface, < 90° view angles are backward-scattering directions, and > 90° view angle are forward-scattering directions. The goniometer utilized a Specim IQ hyperspectral imaging spectrometer. The nominal illumination angle for the measurements was 40°. The average reflectance spectrum for each tree at each view angle was calculated by averaging over all measured samples. The samples comprised of stem bark taken at different heights along the tree stem, from two individual trees per species. The samples were collected from forest stands located in Keimolanmäki, Vantaa, Finland (60°19´N, 24°50´E), in March-April of 2019, and the measurements were conducted within 12 days from the sample collection. The study stands were typical managed and even-aged forests in Finland, approximately 40 years old, and grew on a mesic site type on mineral soil.

The spreadsheet "multiangular_spectra_juola_et_al_2020.csv" in this dataset is organized as follows: first column "tree_species" (pinus_sylvestris, picea_abies, betula_pendula) indicates the tree species, second column "view_angle" (29, 58, 65, 90, 115, 140) indicates the view angle, and the subsequent columns "wl417.5"- indicate the measured BRF value at that wavelength. A separate list of the wavelengths (without the prefix "wl") is provided in the file "list_of_wavelengths_juola_et_al_2020.csv". The encoding of the csv files is UTF-8.
DOI: 10.5281/zenodo.15301484
title: PanScan: A tertiary analysis tool for pangenome graph
DOI: 10.5281/zenodo.15314528
title: PanScan: A tertiary analysis tool for pangenome graph
DOI: 10.6084/m9.figshare.1476252.v1
title: "Evidence for multiple rhythmic skills" dataset

description: Rhythms, or patterns in time, play a vital role in both speech and music. Proficiency in a number of rhythm skills has been linked to language ability, suggesting that certain rhythmic processes in music and language rely on overlapping resources. However, a lack of understanding about how rhythm skills relate to each other has impeded progress in understanding how language relies on rhythm processing. In particular, it is unknown whether all rhythm skills are linked together, forming a single broad rhythmic competence, or whether there are multiple dissociable rhythm skills. We hypothesized that synchronization and rhythm memory/sequencing form two separate clusters of rhythm skills. This hypothesis was tested with a battery of two synchronization and two rhythm memory tests. Here we show that synchronization to a metronome and the ability to adjust to a changing tempo during synchronization are related skills. The ability to remember rhythms and to drum along to repeating rhythmic sequences are also related. However, we found no relationship between synchronization skills and rhythm memory skills. Thus, synchronization and rhythm memory are dissociable rhythmic aptitudes. This discovery may inform future research disambiguating how distinct rhythm competencies track with specific language functions.
DOI: 10.6084/m9.figshare.23265056.v1
title: Additional file 3 of Association between the person-centered maternity care experience and mental health after delivery in urban and rural Dhading, Nepal: a cross-sectional study

description: Additional File 3: Datasets
DOI: 10.6084/m9.figshare.23661354.v1
title: interact_2

description: Interact effects between 2 continuous variables
DOI: 10.6084/m9.figshare.28190957.v2
title: submesoscale modelling figures data at Changjiang River

description: This item shows submesoscale modelling figures data used at manuscript '<b>Tidal Modulation of Submesoscale Dynamics in the Yangtze River Estuary</b>'.The model domain spans the entire Yangtze River estuary (29.5°N-32°N, 120°E-124°E), with a horizontal resolution of approximately 1 km and 50 vertical coordinate levels. The simulation incorporates 16 tidal constituents and uses 6-hourly climatological atmospheric forcing from the European Centre for Medium-Range Weather Forecasts (ECMWF) operational model analysis as surface boundary conditions.The model is two-way nested from the climatological simulation of China's marginal seas described by Sun et al. (2019), which has been well-validated against various observational datasets. The monthly climatological mean discharges of the Yangtze River and Qiantang River are incorporated into the model. Following a 20-year spin-up, the model reached a state of equilibrium. To assess the effects of tidal forcing on submesoscale dynamics, we conducted two sets of simulations: one with tidal forcing and one without. The tidal and non-tidal analyses utilize hourly and daily outputs over the month of August, respectively.