cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23090268.v1
title: Statistical process control of manufacturing tablets for antiretroviral therapy

description: Abstract In this study, the manufacturing process of lamivudine (3TC) and zidovudine (AZT) tablets (150+300 mg respectively) was evaluated using statistical process control (SPC) tools. These medicines are manufactured by the Fundação para o Remédio Popular “Chopin Tavares de Lima” (FURP) laboratory, and are distributed free of charge to patients infected with HIV by the Ministry of Health DST/AIDS national program. Data of 529 batches manufactured from 2012 to 2015 were collected. The critical quality attributes of weight variation, uniformity of dosage units, and dissolution were evaluated. Process stability was assessed using control charts, and the capability indices Cp, Cpk, Pp, and Ppk (process capability; process capability adjusted for non-centered distribution; potential or global capability of the process; and potential process capability adjusted for non-centered distribution, respectively) were evaluated. 3TC dissolution data from 2013 revealed a non-centered process and lack of consistency compared to the other years, showing Cpk and Ppk lower than 1.0 and the chance of failure of 2,483 in 1,000,000 tablets. Dissolution data from 2015 showed process improvement, revealed by Cpk and Ppk equal to 2.19 and 1.99, respectively. Overall, the control charts and capability indices showed the variability of the process and special causes. Additionally, it was possible to point out the opportunities for process changes, which are fundamental for understanding and supporting a continuous improvement environment.
DOI: 10.6084/m9.figshare.22671271.v1
title: Autophagy-overactivated microbial nanocomposite engineered from oncolytic adenoviruses for the cascade enhancement of cancer immunotherapy

description: The source data of our article
DOI: 10.6084/m9.figshare.22671271
title: Autophagy-overactivated microbial nanocomposite engineered from oncolytic adenoviruses for the cascade enhancement of cancer immunotherapy

description: The source data of our article
DOI: 10.6084/m9.figshare.22736519.v1
title: Imaging quantized vortex rings in superfluid helium to evaluate quantum dissipation

description: The Source Data file contains the data associated with the figures included in the paper.
DOI: 10.6084/m9.figshare.22736519
title: Imaging quantized vortex rings in superfluid helium to evaluate quantum dissipation

description: The Source Data file contains the data associated with the figures included in the paper.
DOI: 10.6084/m9.figshare.23090289
title: Strategies for the management of irrigation with saline water and nitrogen fertilization in millet crop

description: ABSTRACT It is believed that nitrogen fertilization will attenuate the salt stress on pearl millet plants. Thus, the objective was to evaluate the agronomic performance of the millet crop under different saline water irrigation strategies and nitrogen fertilization. The experimental design adopted was completely randomized (CRD), in a 4 x 2 factorial scheme, with 4 replicates, with the first factor being four irrigation strategies: S1 = low-salinity water (W1) = 0.3 dS m-1 throughout the cycle; S2 = saline water (W2) = 4.0 dS m-1 from 30 days after sowing - DAS; S3 = W2 from 45 DAS; and S4 = W2 from 65 DAS; and the second factor being two nitrogen doses (60 and 120 kg ha-1 of N). At the end of the experiment, the following variables were evaluated: photosynthesis, transpiration, stomatal conductance, instantaneous water use efficiency, internal CO2 concentration, leaf temperature, plant height, stem diameter, root length, panicle length, leaf dry mass, stem dry mass and root dry mass. Fertilization with 60 and 120 kg ha-1 promotes greater photosynthesis, transpiration, stomatal conductance and internal CO2 concentration in millet plants under the strategies S1, S2 and S3. The strategies S1 and S4 were more efficient to increase the efficient use of water and reduce leaf temperature.
DOI: 10.6084/m9.figshare.23090289.v1
title: Strategies for the management of irrigation with saline water and nitrogen fertilization in millet crop

description: ABSTRACT It is believed that nitrogen fertilization will attenuate the salt stress on pearl millet plants. Thus, the objective was to evaluate the agronomic performance of the millet crop under different saline water irrigation strategies and nitrogen fertilization. The experimental design adopted was completely randomized (CRD), in a 4 x 2 factorial scheme, with 4 replicates, with the first factor being four irrigation strategies: S1 = low-salinity water (W1) = 0.3 dS m-1 throughout the cycle; S2 = saline water (W2) = 4.0 dS m-1 from 30 days after sowing - DAS; S3 = W2 from 45 DAS; and S4 = W2 from 65 DAS; and the second factor being two nitrogen doses (60 and 120 kg ha-1 of N). At the end of the experiment, the following variables were evaluated: photosynthesis, transpiration, stomatal conductance, instantaneous water use efficiency, internal CO2 concentration, leaf temperature, plant height, stem diameter, root length, panicle length, leaf dry mass, stem dry mass and root dry mass. Fertilization with 60 and 120 kg ha-1 promotes greater photosynthesis, transpiration, stomatal conductance and internal CO2 concentration in millet plants under the strategies S1, S2 and S3. The strategies S1 and S4 were more efficient to increase the efficient use of water and reduce leaf temperature.
DOI: 10.6084/m9.figshare.23090347
title: The great Latin America debt crisis: a decade of asymmetric adjustment

description: ABSTRACT Latin America has entered a new phase of abundance of capital inflows, bearing some resemblance to the episode of 70’s. In this paper a review is made of the origins of indebtment in the 70’s, of the emergence of the crisis in the early 80’s, and of the management by creditors and debtors during that decade. Some lessons are derived about the working of international financial markets and policy implications.
DOI: 10.6084/m9.figshare.23090349
title: Hereditary hemochromatosis beyond hyperferritinemia: Clinical and laboratory investigation of the patient’s profile submitted to phlebotomy in two reference centers in southern Brazil

description: Abstract Hereditary Hemochromatosis is a disorder characterized by iron deposition in several organs and hyperferritinemia. The most studied variants are linked to the HFE gene. In Brazil, surveys that characterize this population are scarce, with no sampling in the state of Rio Grande do Sul. Our objective is to carry out a data collection focusing on the profile of this population and the influence of the most frequently HFE variants. Two centers were enrolled: Hospital de Clínicas de Porto Alegre and Hospital São Vicente de Paulo. Patients with hyperferritinemia and undergoing phlebotomy were invited. Clinical data were collected, including HFE investigation. Among the descriptive data, the allele frequency of the C282Y variant (0.252) stands out, which differs from the national scenario. Systemic arterial hypertension was the most cited comorbidity. Differences between centers were observed, highlighting higher frequency of H63D cases in HSVP (p&lt;0.01). Genotypes were stratified according to deleterious effect of C282Y variant. Higher transferrin saturation and number of phlebotomies were observed in the C282Y/C282Y cases (p&lt;0.001). Positive family history for hyperferritinemia was more prevalent in compound heterozygotes (p&lt;0.01). The results presented confirm the importance of encouraging such studies and reiterate the need for greater attention to this population.
DOI: 10.6084/m9.figshare.23090349.v1
title: Hereditary hemochromatosis beyond hyperferritinemia: Clinical and laboratory investigation of the patient’s profile submitted to phlebotomy in two reference centers in southern Brazil

description: Abstract Hereditary Hemochromatosis is a disorder characterized by iron deposition in several organs and hyperferritinemia. The most studied variants are linked to the HFE gene. In Brazil, surveys that characterize this population are scarce, with no sampling in the state of Rio Grande do Sul. Our objective is to carry out a data collection focusing on the profile of this population and the influence of the most frequently HFE variants. Two centers were enrolled: Hospital de Clínicas de Porto Alegre and Hospital São Vicente de Paulo. Patients with hyperferritinemia and undergoing phlebotomy were invited. Clinical data were collected, including HFE investigation. Among the descriptive data, the allele frequency of the C282Y variant (0.252) stands out, which differs from the national scenario. Systemic arterial hypertension was the most cited comorbidity. Differences between centers were observed, highlighting higher frequency of H63D cases in HSVP (p&lt;0.01). Genotypes were stratified according to deleterious effect of C282Y variant. Higher transferrin saturation and number of phlebotomies were observed in the C282Y/C282Y cases (p&lt;0.001). Positive family history for hyperferritinemia was more prevalent in compound heterozygotes (p&lt;0.01). The results presented confirm the importance of encouraging such studies and reiterate the need for greater attention to this population.
DOI: 10.6084/m9.figshare.23090365.v1
title: Individual job performance: Propositions for a personalized measurement and a comprehensive diagnosis

description: Abstract Purpose: Individual job performance is an important phenomenon for organizations but is difficult to measure and often with restricted diagnoses. The aim of this study was to present a set of general indicators of individual performance at work that contemplate different dimensions of this construct to support a personalized measurement and a comprehensive diagnosis. Originality/value: It presents a set of items, composed of eight behavioral categories, that allows for a comprehensive approach to work performance and a personalized way of measuring it in different professional areas and roles. Design/methodology/approach: This work followed a theoretical stage and an empirical one. In the former one, the theoretical model was chosen, the construct was operationalized, and job performance scales’ items were selected. In the empirical stage, the items were classified, selected, and adapted according to the dimensions of the chosen theoretical model, based on judges’ analyses (n = 16), expert panel (n = 6), and semantic validation by professionals (n = 9). Findings: The study generated 56 items for measuring job performance, divided into eight dimensions, according to the theoretical model adopted. Its use will allow a careful measurement of performance, with comprehensive diagnostics on the topic. Additionally, the findings allow academics and managers to raise the level of the debate about the construct to favor theoretical and methodological advances in the area.
DOI: 10.6084/m9.figshare.23090365
title: Individual job performance: Propositions for a personalized measurement and a comprehensive diagnosis

description: Abstract Purpose: Individual job performance is an important phenomenon for organizations but is difficult to measure and often with restricted diagnoses. The aim of this study was to present a set of general indicators of individual performance at work that contemplate different dimensions of this construct to support a personalized measurement and a comprehensive diagnosis. Originality/value: It presents a set of items, composed of eight behavioral categories, that allows for a comprehensive approach to work performance and a personalized way of measuring it in different professional areas and roles. Design/methodology/approach: This work followed a theoretical stage and an empirical one. In the former one, the theoretical model was chosen, the construct was operationalized, and job performance scales’ items were selected. In the empirical stage, the items were classified, selected, and adapted according to the dimensions of the chosen theoretical model, based on judges’ analyses (n = 16), expert panel (n = 6), and semantic validation by professionals (n = 9). Findings: The study generated 56 items for measuring job performance, divided into eight dimensions, according to the theoretical model adopted. Its use will allow a careful measurement of performance, with comprehensive diagnostics on the topic. Additionally, the findings allow academics and managers to raise the level of the debate about the construct to favor theoretical and methodological advances in the area.
DOI: 10.6084/m9.figshare.23090367
title: Estimated correlations of ultrasound carcass measurements and physical-chemical components of Santa Ines sheep meat

description: ABSTRACT. The evaluation of the carcass composition of livestock generates relevant information on the quality and final yield of the meat products. The objective of this work was to evaluate correlations the ultrasound measurements in vivo of the Longissimus lumborum with the physical-chemical components of one-year-old Santa Ines sheep bred in extensive systems. The ultrasound evaluation was performed of the rib eye area (USrea), loin depth (USld), loin width (USlw) and subcutaneous fat thickness (USsft). After slaughter, meat cuts were weighed and carcass yield was calculated. The 12th rib on the left side was separated from the carcass and dissected, after which individual bones, muscles and fat were separated and weighed. The components were regrouped, ground and collected for centesimal evaluation. Significant positive correlations (p &lt; 0.05) were found between the ultrasound measurements and meat metrics, except for the loin length, which had low correlation. Significant correlations (p &lt; 0.05) were found between muscles and the measurements of USld, USrea and USsft. The correlations (p &lt; 0.05) between the bones and USld and USrea were negative and significant. USsft presented correlation (p &lt; 0.05) with carcass yield. Thus, the ultrasound measurements associated with the Longissimus lumborum could constitute a valuable tool for evaluating the physical-chemical components and carcass of one-year-old Santa Inês sheep created in extensive systems.
DOI: 10.6084/m9.figshare.23090367.v1
title: Estimated correlations of ultrasound carcass measurements and physical-chemical components of Santa Ines sheep meat

description: ABSTRACT. The evaluation of the carcass composition of livestock generates relevant information on the quality and final yield of the meat products. The objective of this work was to evaluate correlations the ultrasound measurements in vivo of the Longissimus lumborum with the physical-chemical components of one-year-old Santa Ines sheep bred in extensive systems. The ultrasound evaluation was performed of the rib eye area (USrea), loin depth (USld), loin width (USlw) and subcutaneous fat thickness (USsft). After slaughter, meat cuts were weighed and carcass yield was calculated. The 12th rib on the left side was separated from the carcass and dissected, after which individual bones, muscles and fat were separated and weighed. The components were regrouped, ground and collected for centesimal evaluation. Significant positive correlations (p &lt; 0.05) were found between the ultrasound measurements and meat metrics, except for the loin length, which had low correlation. Significant correlations (p &lt; 0.05) were found between muscles and the measurements of USld, USrea and USsft. The correlations (p &lt; 0.05) between the bones and USld and USrea were negative and significant. USsft presented correlation (p &lt; 0.05) with carcass yield. Thus, the ultrasound measurements associated with the Longissimus lumborum could constitute a valuable tool for evaluating the physical-chemical components and carcass of one-year-old Santa Inês sheep created in extensive systems.
DOI: 10.5281/zenodo.7716066
title: Canine mammary tumors histopathological image classification by computer-aided pathology_ supplementary files

description: Supplementary files
DOI: 10.5281/zenodo.7716065
title: Canine mammary tumors histopathological image classification by computer-aided pathology_ supplementary files

description: Supplementary files
DOI: 10.6084/m9.figshare.23090382
title: Japanese investment in liberalizing Latin American economies: current pattern and possible impacts of FTA initiatives

description: ABSTRACT This paper analyzes Japanese investments in Latin America, especially in Chile, Mexico, Argentina, Venezuela and Brazil. In addition, it discusses the possible impacts that the free trade agreements being implemented in the region would have on these investments.
DOI: 10.6084/m9.figshare.23090382.v1
title: Japanese investment in liberalizing Latin American economies: current pattern and possible impacts of FTA initiatives

description: ABSTRACT This paper analyzes Japanese investments in Latin America, especially in Chile, Mexico, Argentina, Venezuela and Brazil. In addition, it discusses the possible impacts that the free trade agreements being implemented in the region would have on these investments.
DOI: 10.6084/m9.figshare.23090385.v1
title: Insect meal in poultry feed: a potential protein source

description: ABSTRACT. The present study aims to conduct a review on the potential use of insect meal as an alternative protein source in poultry feed, particularly to serve the rearing of free-range chickens. Insects are already part of the diet of birds in their natural habitat, and the availability of low-cost alternative foods with low environmental impact is essential for the development of the activity. The review comprehended studies that used meals consisting of silkworm (Bombyx mori) chrysalis, earthworm (Eisenia foetida), housefly (Musca domestica), black soldier fly (Hermetia illucens) and mealworm beetle (Tenebrio molitor) to replace plant-based protein sources. In general, insect meals have a high content of crude protein and ether extract, as well as an essential amino acid profile suitable for poultry feeding. The addition of insect meal in poultry feed normally shows good results as to growth performance and egg production, without causing a negative effect on carcass characteristics, meat sensory quality and egg quality, presenting itself as an alternative protein source with good prospects for replacing plant-based sources in poultry feed.
DOI: 10.6084/m9.figshare.23090385
title: Insect meal in poultry feed: a potential protein source

description: ABSTRACT. The present study aims to conduct a review on the potential use of insect meal as an alternative protein source in poultry feed, particularly to serve the rearing of free-range chickens. Insects are already part of the diet of birds in their natural habitat, and the availability of low-cost alternative foods with low environmental impact is essential for the development of the activity. The review comprehended studies that used meals consisting of silkworm (Bombyx mori) chrysalis, earthworm (Eisenia foetida), housefly (Musca domestica), black soldier fly (Hermetia illucens) and mealworm beetle (Tenebrio molitor) to replace plant-based protein sources. In general, insect meals have a high content of crude protein and ether extract, as well as an essential amino acid profile suitable for poultry feeding. The addition of insect meal in poultry feed normally shows good results as to growth performance and egg production, without causing a negative effect on carcass characteristics, meat sensory quality and egg quality, presenting itself as an alternative protein source with good prospects for replacing plant-based sources in poultry feed.
DOI: 10.6084/m9.figshare.23090400
title: Clinical outcomes of intravitreal treatment for ocular toxoplasmosis: systematic review and meta-analysis

description: ABSTRACT Background: Ocular toxoplasmosis is the leading cause of infectious posterior uveitis worldwide, accounting for 30-50% of all cases in immunocompetent patients. Conventional treatment is associated with adverse effects and does not prevent recurrence. Intravitreal drug administration can improve disease outcomes and reduce side effects. Herein, we conducted a systematic review and meta-analysis on the efficacy of intravitreal injections for treating ocular toxoplasmosis. Methods: The systematic search was conducted using PubMed, SciELO, and Google Scholar with the descriptors “ocular toxoplasmosis” AND “intravitreal”. We analyzed studies that met the inclusion criteria, i.e., experimental cases in patients treated intravitreally for ocular toxoplasmosis. Considering the systematic review, we focused on the number of intravitreal injections, the therapeutic drug class, and the presence of preexisting conditions. To assess the efficacy of intravitreal injections, a meta-analysis was performed using visual acuity, side effects, disease recurrence, and inflammatory responses as variables. Results: Intravitreal injection-induced side effects were rarely observed (0.49% [0.00, 1.51%] ). The use of antiparasitic and anti-inflammatory drugs afforded improved visual acuity (99.81% [98.60, 100.00%]) and marked effectiveness in treating ocular toxoplasmosis. Conclusions: Intravitreal injections may facilitate the successful treatment of ocular toxoplasmosis. However, clinicians should carefully evaluate the presence of preexisting conditions for ocular toxoplasmosis or previous diseases, as these can impact the decision to administer intravitreal injections.
DOI: 10.6084/m9.figshare.23090400.v1
title: Clinical outcomes of intravitreal treatment for ocular toxoplasmosis: systematic review and meta-analysis

description: ABSTRACT Background: Ocular toxoplasmosis is the leading cause of infectious posterior uveitis worldwide, accounting for 30-50% of all cases in immunocompetent patients. Conventional treatment is associated with adverse effects and does not prevent recurrence. Intravitreal drug administration can improve disease outcomes and reduce side effects. Herein, we conducted a systematic review and meta-analysis on the efficacy of intravitreal injections for treating ocular toxoplasmosis. Methods: The systematic search was conducted using PubMed, SciELO, and Google Scholar with the descriptors “ocular toxoplasmosis” AND “intravitreal”. We analyzed studies that met the inclusion criteria, i.e., experimental cases in patients treated intravitreally for ocular toxoplasmosis. Considering the systematic review, we focused on the number of intravitreal injections, the therapeutic drug class, and the presence of preexisting conditions. To assess the efficacy of intravitreal injections, a meta-analysis was performed using visual acuity, side effects, disease recurrence, and inflammatory responses as variables. Results: Intravitreal injection-induced side effects were rarely observed (0.49% [0.00, 1.51%] ). The use of antiparasitic and anti-inflammatory drugs afforded improved visual acuity (99.81% [98.60, 100.00%]) and marked effectiveness in treating ocular toxoplasmosis. Conclusions: Intravitreal injections may facilitate the successful treatment of ocular toxoplasmosis. However, clinicians should carefully evaluate the presence of preexisting conditions for ocular toxoplasmosis or previous diseases, as these can impact the decision to administer intravitreal injections.