cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20522970.v1
title: Correlation between productive and interior traits of steers of different genotypes

description: ABSTRACT The objective was to study the productive and biological traits of young cattle of the Kalmyk breed and its crosses. The experiment was conducted on 4 groups of steers, 10 heads each, at OAO Shurupovskoe, Frolovsky District, Volgograd Region. The experimental steers were kept in rooms separately in groups on a deep bed of straw and had free access to walking yards with mounds. The hemoglobin content and the numbers of erythrocytes and leukocytes were determined on a Medonic CA 530 hematological analyzer. The total protein in blood serum and protein fractions were found on an automatic biochemical analyzer Stat Faks 1904. The digital experimental data were processed by the variation statistics method in terms of the significance of the compared parameters using the Student's test accepted in biology and animal science. The study evidenced that the contents of morphological elements and proteins in blood reflected the metabolism and potential for crossbred steers to gain muscle mass.
DOI: 10.6084/m9.figshare.20522972
title: POLITICAL RESISTANCE WITHOUT FRIENDLY FIRE: FOR A LINGUISTIC IDEOLOGY OF MIXTURES IN OUR REVOLT

description: ABSTRACT Nowadays we witness the invasion of a belligerent culture in different areas of social life, including politics. As right-wing populism spreads worldwide, a close look at the way language has been used by political leaders and their supporters is necessary (HODGES, 2020). The same can be said about the linguistic beliefs that guide our interpretations of the forms and uses of languages and our ways of triggering political resistance. In this work, we analyze three tweets that criticize the discursive performances of Abraham Weintraub, former Minister of Education of the government of Jair Bolsonaro, when he violated the standard form of the Portuguese language. We aim to investigate the linguistic ideologies that guide such criticisms, assessing the effects they have on political projects interested in defending the rights of socially marginalized groups. For our analyses, we use iconization, fractal recursivity, and erasure (GAL & IRVINE, 2019) as theoretical-analytical constructs. The results of this study indicate that modes of resistance guided by linguistic ideologies that support a pure ideal of language endorse negative meanings associated with popular linguistic resources and, by extension, with socially excluded groups. We argue in favor of linguistic ideologies that embrace different ways of communicating (PINTO, 2013; FABRÍCIO & MOITA LOPES, 2019) as a possible approach to thinking about practices of political resistance that are, in fact, committed to inclusive and social justice agendas.
DOI: 10.6084/m9.figshare.20522972.v1
title: POLITICAL RESISTANCE WITHOUT FRIENDLY FIRE: FOR A LINGUISTIC IDEOLOGY OF MIXTURES IN OUR REVOLT

description: ABSTRACT Nowadays we witness the invasion of a belligerent culture in different areas of social life, including politics. As right-wing populism spreads worldwide, a close look at the way language has been used by political leaders and their supporters is necessary (HODGES, 2020). The same can be said about the linguistic beliefs that guide our interpretations of the forms and uses of languages and our ways of triggering political resistance. In this work, we analyze three tweets that criticize the discursive performances of Abraham Weintraub, former Minister of Education of the government of Jair Bolsonaro, when he violated the standard form of the Portuguese language. We aim to investigate the linguistic ideologies that guide such criticisms, assessing the effects they have on political projects interested in defending the rights of socially marginalized groups. For our analyses, we use iconization, fractal recursivity, and erasure (GAL & IRVINE, 2019) as theoretical-analytical constructs. The results of this study indicate that modes of resistance guided by linguistic ideologies that support a pure ideal of language endorse negative meanings associated with popular linguistic resources and, by extension, with socially excluded groups. We argue in favor of linguistic ideologies that embrace different ways of communicating (PINTO, 2013; FABRÍCIO & MOITA LOPES, 2019) as a possible approach to thinking about practices of political resistance that are, in fact, committed to inclusive and social justice agendas.
DOI: 10.6084/m9.figshare.20484563
title: Myasthenia gravis in clinical practice

description: ABSTRACT Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the main practical aspects of the diagnostic approach, treatment and care of myasthenic patients. Methods: The authors performed a non-systematic critical review summarizing the main practical aspects of myasthenia gravis. Results: Most patients with myasthenia have autoantibodies targeted at acetylcholine receptors or, less commonly, muscle-specific kinase - MuSK. Electrophysiology plays an important role in the diagnosis of neuromuscular junction dysfunction. The central clinical manifestation of myasthenia gravis is fatigable muscle weakness, which can affect eye, bulbar, respiratory, and limb muscles. With rare exceptions, patients have a good response to symptomatic treatment, but corticosteroids and/or immunosuppressants are usually also necessary to obtain good control of the manifestations of the disease. Conclusion: Knowledge of the peculiar aspects of their clinical and electrophysiological presentations is important for the diagnosis. Likewise, specific treatment and response time to each drug are crucial for proper care.
DOI: 10.6084/m9.figshare.20484563.v1
title: Myasthenia gravis in clinical practice

description: ABSTRACT Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the main practical aspects of the diagnostic approach, treatment and care of myasthenic patients. Methods: The authors performed a non-systematic critical review summarizing the main practical aspects of myasthenia gravis. Results: Most patients with myasthenia have autoantibodies targeted at acetylcholine receptors or, less commonly, muscle-specific kinase - MuSK. Electrophysiology plays an important role in the diagnosis of neuromuscular junction dysfunction. The central clinical manifestation of myasthenia gravis is fatigable muscle weakness, which can affect eye, bulbar, respiratory, and limb muscles. With rare exceptions, patients have a good response to symptomatic treatment, but corticosteroids and/or immunosuppressants are usually also necessary to obtain good control of the manifestations of the disease. Conclusion: Knowledge of the peculiar aspects of their clinical and electrophysiological presentations is important for the diagnosis. Likewise, specific treatment and response time to each drug are crucial for proper care.
DOI: 10.6084/m9.figshare.20522975
title: Assessment of the tolerance of soybean seeds to weathering deterioration in the pre-harvest phase by multivariate analysis

description: Abstract: Weathering deterioration in the pre-harvest phase impairs high-quality soybean seed production. The performance of several tests to infer seed quality is common in genotype selection, and multivariate statistics can assist in the interpretations. This study aimed to assess the efficiency of the principal component analysis (PCA) and canonical discriminant analysis (CDA) multivariate statistical methods in assessing the tolerance of seeds of different soybean cultivars to weathering deterioration in the pre-harvest phase under greenhouse conditions. Seeds of six soybean cultivars (DM 6563, BMX Apolo, BMX Potência, NA 5909, NS 5959, and TMG 1175) were produced. Different simulated precipitation levels (0, 60, 120, and 180 mm) were applied in the pre-harvest phase. The seeds were collected and assessed for physiological, physical, and biochemical analyses and the data were analyzed by PCA and CDA techniques. The results showed that PCA and CDA are efficient for assessing the tolerance to weathering deterioration in soybean seeds. PCA and CDA assisted in the recommendation of the tests first germination count, accelerated aging, tetrazolium, percentage of seeds with seed coat wrinkling, protein content, and protease activity in the pre-selection of genotypes for weathering deterioration. PCA and CDA also helped to identify the cultivars DM 6563 and BMX Potência as more susceptible and NA 5909 and TMG 1175 as more tolerant to weathering deterioration in the pre-harvest phase.
DOI: 10.6084/m9.figshare.20522975.v1
title: Assessment of the tolerance of soybean seeds to weathering deterioration in the pre-harvest phase by multivariate analysis

description: Abstract: Weathering deterioration in the pre-harvest phase impairs high-quality soybean seed production. The performance of several tests to infer seed quality is common in genotype selection, and multivariate statistics can assist in the interpretations. This study aimed to assess the efficiency of the principal component analysis (PCA) and canonical discriminant analysis (CDA) multivariate statistical methods in assessing the tolerance of seeds of different soybean cultivars to weathering deterioration in the pre-harvest phase under greenhouse conditions. Seeds of six soybean cultivars (DM 6563, BMX Apolo, BMX Potência, NA 5909, NS 5959, and TMG 1175) were produced. Different simulated precipitation levels (0, 60, 120, and 180 mm) were applied in the pre-harvest phase. The seeds were collected and assessed for physiological, physical, and biochemical analyses and the data were analyzed by PCA and CDA techniques. The results showed that PCA and CDA are efficient for assessing the tolerance to weathering deterioration in soybean seeds. PCA and CDA assisted in the recommendation of the tests first germination count, accelerated aging, tetrazolium, percentage of seeds with seed coat wrinkling, protein content, and protease activity in the pre-selection of genotypes for weathering deterioration. PCA and CDA also helped to identify the cultivars DM 6563 and BMX Potência as more susceptible and NA 5909 and TMG 1175 as more tolerant to weathering deterioration in the pre-harvest phase.
DOI: 10.6084/m9.figshare.20522978
title: Effect of different diet pellet sizes on the growth of juvenile cobia (Rachycentron canadum)

description: ABSTRACT It is known that there is a close relationship between pellet feed size and fish growth. However, the magnitude of this relationship regarding an animals’ feed efficiency is not yet clear. Therefore, the present study conducted at the Virginia Tech - Virginia Seafood Agricultural Research and Extension Center (USA), investigated the effects of three different pellet feed sizes, 1.7mm (EP.1), 2.3 mm (EP.2) and 3.1 mm (EP.3), on the growth of Cobia (Rachycentron canadum) in a recirculating aquaculture system (RAS). Animals were farmed for 55 days in 77.5-liter tanks (6 fish with an initial density of 3.78 g L⁻¹) weighing approximately 41.83±1.24g. The results showed that during the 8-week culture period, there were no significant differences between the animal’s final weight over the different pellet feed sizes (EP.1 - 952.5±40.7g; EP.2 - 1014.5±26.6g; EP.3 - 1030.0±54.8g). However, biomass gain showed significant differences (EP.1 - 704.0±34+.3g; EP.2 - 763.0±27.8g; EP.3 -776.5±51.9g). Consequently, significant differences were also found in the feed conversion factors.
DOI: 10.6084/m9.figshare.20522978.v1
title: Effect of different diet pellet sizes on the growth of juvenile cobia (Rachycentron canadum)

description: ABSTRACT It is known that there is a close relationship between pellet feed size and fish growth. However, the magnitude of this relationship regarding an animals’ feed efficiency is not yet clear. Therefore, the present study conducted at the Virginia Tech - Virginia Seafood Agricultural Research and Extension Center (USA), investigated the effects of three different pellet feed sizes, 1.7mm (EP.1), 2.3 mm (EP.2) and 3.1 mm (EP.3), on the growth of Cobia (Rachycentron canadum) in a recirculating aquaculture system (RAS). Animals were farmed for 55 days in 77.5-liter tanks (6 fish with an initial density of 3.78 g L⁻¹) weighing approximately 41.83±1.24g. The results showed that during the 8-week culture period, there were no significant differences between the animal’s final weight over the different pellet feed sizes (EP.1 - 952.5±40.7g; EP.2 - 1014.5±26.6g; EP.3 - 1030.0±54.8g). However, biomass gain showed significant differences (EP.1 - 704.0±34+.3g; EP.2 - 763.0±27.8g; EP.3 -776.5±51.9g). Consequently, significant differences were also found in the feed conversion factors.
DOI: 10.6084/m9.figshare.20495736
title: Influence of Values and Parenting Styles Perceived by Children in the Value Transmission

description: Abstract In order to better understand the relationship between parenting styles and parental values perceived by children and their values, 119 children were invited to answer the Basic Values Survey - Children’s version, the Parenting Styles Inventory, and a sociodemographic questionnaire. Results showed that the guardian’s perceived value priority does not depend on the parenting style perceived by children. Furthermore, positive parenting style is related to a greater value congruence between guardians and children, and parenting style and values are explanatory variables of the values endorsed by the children. The values and parenting styles perceived by children play an important role in the transmission of values between guardians and children.
DOI: 10.6084/m9.figshare.20495736.v1
title: Influence of Values and Parenting Styles Perceived by Children in the Value Transmission

description: Abstract In order to better understand the relationship between parenting styles and parental values perceived by children and their values, 119 children were invited to answer the Basic Values Survey - Children’s version, the Parenting Styles Inventory, and a sociodemographic questionnaire. Results showed that the guardian’s perceived value priority does not depend on the parenting style perceived by children. Furthermore, positive parenting style is related to a greater value congruence between guardians and children, and parenting style and values are explanatory variables of the values endorsed by the children. The values and parenting styles perceived by children play an important role in the transmission of values between guardians and children.
DOI: 10.6084/m9.figshare.20484522
title: Gene therapy in neuromuscular disorders

description: Abstract Monogenic neuromuscular disorders are potentially treatable through gene therapy. Using viral vectors, a therapeutic transgene aims to restore normal levels of a protein not produced by the defective gene, or to silence a gene whose expression leads to toxic effects. Spinal Muscular Atrophy (SMA) is a good example of a monogenic disease that currently has an AAV9-based vector gene therapy as a therapeutic option. In this review, we intend to discuss the viral vectors and their mechanisms of action, in addition to reviewing the clinical trials that supported the approval of gene therapy (AVXS-101) for SMA as well as neuromuscular diseases that are potentially treatable with gene replacement therapy.
DOI: 10.6084/m9.figshare.20484522.v1
title: Gene therapy in neuromuscular disorders

description: Abstract Monogenic neuromuscular disorders are potentially treatable through gene therapy. Using viral vectors, a therapeutic transgene aims to restore normal levels of a protein not produced by the defective gene, or to silence a gene whose expression leads to toxic effects. Spinal Muscular Atrophy (SMA) is a good example of a monogenic disease that currently has an AAV9-based vector gene therapy as a therapeutic option. In this review, we intend to discuss the viral vectors and their mechanisms of action, in addition to reviewing the clinical trials that supported the approval of gene therapy (AVXS-101) for SMA as well as neuromuscular diseases that are potentially treatable with gene replacement therapy.
DOI: 10.6084/m9.figshare.20522979
title: THE POWER OF FREE: IN SEARCH OF DEMOCRATIC ACADEMIC PUBLISHING STRATEGIES

description: ABSTRACT In this essay, Jan Blommaert discusses fundamental issues on the economic dimension of academic publishing, the reasons and the intentions for publishing as an academic, and the available alternatives. The author presents the conditions of the productive cycle of academic journal publishers and argues that the business model is based on the threefold exploitation of academics’ work, as authors, reviewers, and readers of the articles, and of the institutions and governments who fund the published research. The author criticizes the false solution of “gold” and “green” access and expose the impact of new modes of circulation on the cheapening and high reaches of academic communication. He defends democratic strategies of academic publishing led by the people who do research and argues for our autonomy to promote the primary function of academic publishing: the debate of ideas with the largest possible number of experts in the field.
DOI: 10.6084/m9.figshare.20522979.v1
title: THE POWER OF FREE: IN SEARCH OF DEMOCRATIC ACADEMIC PUBLISHING STRATEGIES

description: ABSTRACT In this essay, Jan Blommaert discusses fundamental issues on the economic dimension of academic publishing, the reasons and the intentions for publishing as an academic, and the available alternatives. The author presents the conditions of the productive cycle of academic journal publishers and argues that the business model is based on the threefold exploitation of academics’ work, as authors, reviewers, and readers of the articles, and of the institutions and governments who fund the published research. The author criticizes the false solution of “gold” and “green” access and expose the impact of new modes of circulation on the cheapening and high reaches of academic communication. He defends democratic strategies of academic publishing led by the people who do research and argues for our autonomy to promote the primary function of academic publishing: the debate of ideas with the largest possible number of experts in the field.
DOI: 10.6084/m9.figshare.20484467
title: Immune-checkpoint inhibitors for glioblastoma: what have we learned?

description: ABSTRACT Background: Glioblastoma, the most common malignant primary brain tumor, remains a lethal disease with few therapeutic options. Immunotherapies, particularly immune checkpoint inhibitors (ICPi), have revolutionized cancer treatment, but their role in glioblastoma is uncertain. Objective: To review the state of immunotherapies in glioblastoma, with an emphasis on recently published ICPi clinical trials. Methods: In this editorial/opinion article, we critically review results of the first generation of trials of ipilimumab, nivolumab and pembrolizumab in glioblastoma, as well as future directions. Results: Expression of PD-L1 is frequent in glioblastoma, ranging from 60-70% of patients. Phase 1 studies of nivolumab with and without ipilimumab, as well as pembrolizumab, showed no new safety concerns in brain tumors, and no neurotoxicity. However, randomized phase 3 trials of nivolumab showed no survival improvements over bevacizumab in recurrent glioblastoma; no role in newly diagnosed disease as a replacement for temozolomide in unmethylated MGMT promoter tumors; and no benefit as an addition to temozolomide in methylated MGMT tumors. However, studies examining post treatment tumor samples have shown signs of increased immunologic response, and occasional long lasting radiographic responses have been seen. A small study of pembrolizumab suggested a potential role as a “neoadjuvant” treatment in resectable recurrent glioblastoma, while other studies are investigating selection of patients with higher mutational burden and novel agents and combinatorial strategies. Conclusion: Despite initial negative trials, immunotherapy remains of high interest in glioblastoma, and many trials are still ongoing. Improving our mechanistic understanding of the immunosuppression and T cell dysfunction induced by both tumor and the CNS microenvironment remains however crucial for the development of successful immunotherapeutic approaches in this disease.
DOI: 10.6084/m9.figshare.20484467.v1
title: Immune-checkpoint inhibitors for glioblastoma: what have we learned?

description: ABSTRACT Background: Glioblastoma, the most common malignant primary brain tumor, remains a lethal disease with few therapeutic options. Immunotherapies, particularly immune checkpoint inhibitors (ICPi), have revolutionized cancer treatment, but their role in glioblastoma is uncertain. Objective: To review the state of immunotherapies in glioblastoma, with an emphasis on recently published ICPi clinical trials. Methods: In this editorial/opinion article, we critically review results of the first generation of trials of ipilimumab, nivolumab and pembrolizumab in glioblastoma, as well as future directions. Results: Expression of PD-L1 is frequent in glioblastoma, ranging from 60-70% of patients. Phase 1 studies of nivolumab with and without ipilimumab, as well as pembrolizumab, showed no new safety concerns in brain tumors, and no neurotoxicity. However, randomized phase 3 trials of nivolumab showed no survival improvements over bevacizumab in recurrent glioblastoma; no role in newly diagnosed disease as a replacement for temozolomide in unmethylated MGMT promoter tumors; and no benefit as an addition to temozolomide in methylated MGMT tumors. However, studies examining post treatment tumor samples have shown signs of increased immunologic response, and occasional long lasting radiographic responses have been seen. A small study of pembrolizumab suggested a potential role as a “neoadjuvant” treatment in resectable recurrent glioblastoma, while other studies are investigating selection of patients with higher mutational burden and novel agents and combinatorial strategies. Conclusion: Despite initial negative trials, immunotherapy remains of high interest in glioblastoma, and many trials are still ongoing. Improving our mechanistic understanding of the immunosuppression and T cell dysfunction induced by both tumor and the CNS microenvironment remains however crucial for the development of successful immunotherapeutic approaches in this disease.