cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15151/esrf-es-749575299
title: Characterization of a transient high-valent nonheme Fe(V)=O species by means of a combined time-resolved UV-Vis/XAS investigation

description: Selective C-H bond oxidation is one of the main goals in organic chemistry and the use of non-heme iron catalysts has emerged as one of its most promising approaches. Highly reactive Fe(V)=O intermediates are invoked as the key oxidizing species in enzymatic and bioinspired oxidations with H2O2 acting as the terminal oxidant, but their direct detection remains elusive. Recently, the generation of Fe(V)=O species from Fe(III)-OOH hydroperoxides has been allowed by the assistance of a strong acid, but the labile Fe(V) species has not yet been directly detected. Our project aims to fill in this gap by monitoring the reaction between an Fe(III)-OOH complex and triflic acid using coupled time-resolved UV-Vis/XAS spectroscopies. The resulting electronic and structural insights are expected to definitely disclose the nature of the key Fe(V)=O oxidizing intermediates allowing a rational design of highly efficient non-heme complexes better mimicking the natural reactivity of iron oxygenases.
DOI: 10.15151/esrf-es-773179826
title: Study of the catalyst for LOHC de-hydrogenation

description: Pt catalyst will be studied during de-hydrogenation reaction of Liquid Organic Hydrogen Carriers (LOHC).
DOI: 10.15151/esrf-es-790926699
title: Ferroelectric defects as origin for resistive switching in Sr-deficient SrTiO3 thin films

description: trontium deficient thin SrTiO3 films show resistive switching that is assumed to be related to ferroelectric antisite defects where Ti occupies a Sr position. With increasing deficiency, these defects form polar regions (domains) in the lattice that can be switched by means of an electric field. In our model, the orientation of the spontaneous polarization defines the resistance through the film leading to the resistive switching behaviour. In this proposal, we want to verify the relation of ferroelectric and resistive switchen. In addition, we intend to determine the structure of polar defects in strontium deficient SrTiO3 as function of applied electric field . This will be done by a combination of X-ray absorption spectroscopy (XAS) and in-situ resonant X-ray diffraction (RXD).
DOI: 10.5281/zenodo.6481867
title: Data and Codes of Characterizing Uncertainties of Earth System Modeling with Heterogeneous Many-core Architecture Computing

description: These are the supporting information to verify the results in the paper, including input data, model outputs, the postprocessing scripts and the source codes.
DOI: 10.6084/m9.figshare.19645869
title: Supplementary Material for: Efficacy and Safety of Blood Derivative Therapy for Patients with COVID-19: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> The outbreak of COVID-19 has resulted in more than 200 million infections and 4 million deaths. The blood derivative therapy represented by intravenous immunoglobulin (IVIG) and convalescent plasma (CP) therapy may be the promising therapeutics for COVID-19. <b><i>Methods:</i></b> A systematic article search was performed for eligible studies published up to August 3, 2021, through the PubMed, Embase, Cochrane Library. The included articles were screened by using rigorous inclusion and exclusion criteria. All analyses were conducted using Review Manager 5.4. Quality of studies and risk of bias were evaluated. <b><i>Results:</i></b> A total of 5 IVIG therapy and 13 CP therapy randomized controlled trials were included with a sample size of 13,696 subjects diagnosed with COVID-19. IVIG could reduce the mortality compared with the control group (RR 0.65, 95% CI: 0.46–0.93, <i>p</i> = 0.02). The use of CP did not effectively reduce the mortality (RR 0.97, 95% CI: 0.91–1.03, <i>p</i> = 0.38), the length of hospital stay (MD −0.47, 95% CI: −4.13 to 3.20, <i>p</i> = 0.80), and the mechanical ventilation use (RR = 0.98, 95% CI: 0.89–1.07, <i>p</i> = 0.62) of the patients with COVID-19. Treatment with IVIG or CP was not significantly associated with an increase in reported adverse events (RR 1.07, 95% CI: 0.94–1.22, <i>p</i> = 0.28). <b><i>Conclusions:</i></b> Treatment with IVIG could be effective and safe to improve survival for patients with COVID-19. But the benefit of CP in the treatment of COVID-19 is limited. The certainty of the evidence was moderate for all outcomes.
DOI: 10.6084/m9.figshare.18524150.v1
title: Supplementary Material for: <b><i>Borrelia</i></b> Ocular Infection: A Case Report and a Systematic Review of Published Cases

description: <b><i>Introduction:</i></b> Lyme borreliosis can cause many diverse manifestations, also ocular disease where the diagnosis of ocular borreliosis is challenging. The primary aim was to report on the evidence of <i>Borrelia spirochetes</i> in the ocular tissue in presumed ocular borreliosis. <b><i>Methods:</i></b> A systematic review of pathological eye conditions was performed where <i>Borrelia</i> has been suspected in relevant ocular tissue, together with a case report of diagnosed uveitis with polymerase chain reaction (PCR)-confirmed <i>Borrelia afzelii</i> in the vitreous. The evidence for clinical and laboratory diagnosis was evaluated systematically. As a secondary aim, the treatment of ocular <i>Borrelia</i> infection was also evaluated for confirmed cases. <b><i>Results:</i></b> Thirteen includable studies were found, and after the removal of case duplicates, eleven unique cases were extracted. Apart from the present case report, 4 other cases reported strong evidence for the detection of <i>B. spirochetes</i> in ocular tissue. Four cases presented reasonable evidence for assumed detected <i>Borrelia</i>, while three additional cases showed only weak diagnostic credibility that <i>Borrelia</i> was detected. <b><i>Conclusion:</i></b> This systematic review, including all reported cases and our case report, supports evidence of ocular infection of <i>Borrelia</i> species. Furthermore, in case of suspicion of infection and seronegativity, it is justified to look for <i>Borrelia</i> in eye tissue samples. In addition, microscopy without using PCR is not sufficient to confirm the diagnosis of borreliosis on ocular tissue. In the articles studied, there was no unambiguous recommendation of treatment.
DOI: 10.6084/m9.figshare.18524150
title: Supplementary Material for: <b><i>Borrelia</i></b> Ocular Infection: A Case Report and a Systematic Review of Published Cases

description: <b><i>Introduction:</i></b> Lyme borreliosis can cause many diverse manifestations, also ocular disease where the diagnosis of ocular borreliosis is challenging. The primary aim was to report on the evidence of <i>Borrelia spirochetes</i> in the ocular tissue in presumed ocular borreliosis. <b><i>Methods:</i></b> A systematic review of pathological eye conditions was performed where <i>Borrelia</i> has been suspected in relevant ocular tissue, together with a case report of diagnosed uveitis with polymerase chain reaction (PCR)-confirmed <i>Borrelia afzelii</i> in the vitreous. The evidence for clinical and laboratory diagnosis was evaluated systematically. As a secondary aim, the treatment of ocular <i>Borrelia</i> infection was also evaluated for confirmed cases. <b><i>Results:</i></b> Thirteen includable studies were found, and after the removal of case duplicates, eleven unique cases were extracted. Apart from the present case report, 4 other cases reported strong evidence for the detection of <i>B. spirochetes</i> in ocular tissue. Four cases presented reasonable evidence for assumed detected <i>Borrelia</i>, while three additional cases showed only weak diagnostic credibility that <i>Borrelia</i> was detected. <b><i>Conclusion:</i></b> This systematic review, including all reported cases and our case report, supports evidence of ocular infection of <i>Borrelia</i> species. Furthermore, in case of suspicion of infection and seronegativity, it is justified to look for <i>Borrelia</i> in eye tissue samples. In addition, microscopy without using PCR is not sufficient to confirm the diagnosis of borreliosis on ocular tissue. In the articles studied, there was no unambiguous recommendation of treatment.
DOI: 10.6084/m9.figshare.19180619
title: Supplementary Material for: Association between polycystic ovarian syndrome and risk of gestational diabetes mellitus: A meta-analysis

description: Objectives: The results of studies regarding the association between polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) are controversial. Design: This meta-analysis was conducted to evaluate the relationship between PCOS and GDM. Methods: English language articles published before July 2021 were included by searching in databases: PubMed, EMBASE, Web of Science, Medline and Google Scholar. All these results were computed using STATA 12.0 software. The random-effects models were used to calculate summary odds ratio (OR) or relative risk (RR) and 95% confidence interval (CI) when the heterogeneity was high; Inversely, the fixed-effects models were used to calculate summary OR/RR and 95% CI when the heterogeneity was low. Results: The present study showed that PCOS was significantly associated with an increased risk of GDM with a random effects model (OR/RR = 2.02, 95% CI 1.74 to 2.34, I2 = 79.5%, p &lt; 0.0001). Subgroup analysis indicated an elevated risk of GDM in PCOS patients in both retrospective and prospective studies (retrospective studies: OR = 1.89, 95% CI 1.62 to 2.20; prospective studies: RR = 2.85, 95% CI 1.77 to 4.60). In addition, subgroup analysis indicated an elevated risk of GDM in PCOS patients in both Caucasian and Asian populations (Caucasian populations: OR/RR = 2.47, 95% CI 1.99 to 3.07; prospective studies: OR/RR = 1.58, 95% CI 1.23 to 2.02). Conclusion: Overall, findings of the meta-analysis showed that women with PCOS have an elevated risk of GDM compared to women without PCOS. Limitations: First, on account of sources of information, the role of several variables including BMI, the severity of GDM and serum lipid level in the association between PCOS and GDM can not be evaluated. Second, only studies published in English and Chinese were included, and the publish bias is impossible to avoid.
DOI: 10.25442/hku.19522474
title: Supporting data for "The antineoplastic impact of thymoquinone from nigella sativa on small cell lung cancer"

description: Dataset 1 shows the effects of thymoquinone (TQ), a naturally-derived compound from black cumin (<i>Nigella sativa</i>), on small cell lung cancer (SCLC) cells. TQ dose-dependently reduces cell viability of SCLC cells. Dataset 2 demonstrates the induction of S-phase arrest in SCLC cells. TQ halts cancer cell growth and destines the cell to apoptosis. Dataset 3 shows the effect of TQ on the expression of STAT3, a vital protein in cell proliferation.
DOI: 10.25442/hku.19522474.v1
title: Supporting data for "The antineoplastic impact of thymoquinone from nigella sativa on small cell lung cancer"

description: Dataset 1 shows the effects of thymoquinone (TQ), a naturally-derived compound from black cumin (<i>Nigella sativa</i>), on small cell lung cancer (SCLC) cells. TQ dose-dependently reduces cell viability of SCLC cells. Dataset 2 demonstrates the induction of S-phase arrest in SCLC cells. TQ halts cancer cell growth and destines the cell to apoptosis. Dataset 3 shows the effect of TQ on the expression of STAT3, a vital protein in cell proliferation.
DOI: 10.25442/hku.19524568
title: Supporting data for Enabling Novel Energy Conversion Schemes By (1) Developing Facile and Green Nanofabrication Techniques (2) Designing Bioinspired Heterogeneous Electrocatalysts (3) Constructing Efficient and Selective Hybrid Bilayer Membrane Platforms

description: This dataset includes the materials' physical characterization and electrochemical performance and the dataset has been well sorted by different methologoies and techniques utilized.
DOI: 10.25442/hku.19524568.v1
title: Supporting data for Enabling Novel Energy Conversion Schemes By (1) Developing Facile and Green Nanofabrication Techniques (2) Designing Bioinspired Heterogeneous Electrocatalysts (3) Constructing Efficient and Selective Hybrid Bilayer Membrane Platforms

description: This dataset includes the materials' physical characterization and electrochemical performance and the dataset has been well sorted by different methologoies and techniques utilized.
DOI: 10.25442/hku.19593799
title: Supporting data for "Corrosion rate of macrocell corrosion in reinforced concrete and service life modeling of carbonated concrete containing supplementary cementitious materials "

description: This dataset includes the raw and processed data for the thesis "Corrosion rate of macrocell corrosion in reinforced concrete and service life modeling of carbonated concrete containing supplementary cementitious materials". <br> Folder 1 corresponds to Chapter 3 in the thesis. This folder includes the raw and processed data for the corrosion rate measurement experiments conducted in simulated pore solutions. <br> Folder 2 corresponds to Chapter 4 in the thesis. This folder includes the raw and processed data for the corrosion rate measurement experiments conducted in reinforced concrete columns. <br> Folder 3 corresponds to Chapter 5 in the thesis. This folder includes the raw and processed data for the macrocell corrosion experiments conducted in carbonated SCM concrete specimens. <br> Folder 4 corresponds to Chapter 6 in the thesis. This folder includes the raw and processed data for service life modeling resutls in carbonated SCM concrete specimens. <br>
DOI: 10.25442/hku.19593799.v1
title: Supporting data for "Corrosion rate of macrocell corrosion in reinforced concrete and service life modeling of carbonated concrete containing supplementary cementitious materials "

description: This dataset includes the raw and processed data for the thesis "Corrosion rate of macrocell corrosion in reinforced concrete and service life modeling of carbonated concrete containing supplementary cementitious materials". <br> Folder 1 corresponds to Chapter 3 in the thesis. This folder includes the raw and processed data for the corrosion rate measurement experiments conducted in simulated pore solutions. <br> Folder 2 corresponds to Chapter 4 in the thesis. This folder includes the raw and processed data for the corrosion rate measurement experiments conducted in reinforced concrete columns. <br> Folder 3 corresponds to Chapter 5 in the thesis. This folder includes the raw and processed data for the macrocell corrosion experiments conducted in carbonated SCM concrete specimens. <br> Folder 4 corresponds to Chapter 6 in the thesis. This folder includes the raw and processed data for service life modeling resutls in carbonated SCM concrete specimens. <br>
DOI: 10.25442/hku.19593034
title: Supporting data for “The Protective Role of Tubular β-catenin in Acute Kidney Injury”

description: Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction in chronic kidney fibrosis, little is known of the influence of β-catenin on mitochondrial function in AKI. To decipher this interaction, we generated an inducible mouse model of tubule-specific β-catenin overexpression (TubCat), and a model of tubule-specific β-catenin depletion (TubcatKO), and induced septic AKI in these mice with lipopolysaccharide (LPS) and aseptic AKI with bilateral ischemia-reperfusion. In both AKI models, tubular β-catenin stabilization in TubCat animals significantly reduced BUN/serum creatinine, tubular damage (NGAL-positive tubules), apoptosis (TUNEL-positive cells) and necroptosis (phosphorylation of MLKL and RIP3) through activating AKT phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased PGC-1α and NRF1) and restored mitochondrial mass (increased TIM23) to re-establish mitochondrial homeostasis (increased fusion markers OPA1, MFN2, and decreased fission protein DRP1) through the FOXO3/PGC-1α signaling cascade. Conversely, kidney function loss and histological damage, tubular cell death, and mitochondrial dysfunction were all aggravated in TubCatKO mice. Mechanistically, β-catenin transfection maintained mitochondrial mass and activated PGC-1α via FOXO3 in LPS-exposed HK-2 cells. Taken together, these findings provide evidence that tubular β-catenin mitigates cell death and restores mitochondrial homeostasis in AKI through the common mechanisms associated with activation of AKT/p53 and FOXO3/PGC-1α signaling pathways.
DOI: 10.25442/hku.19593034.v1
title: Supporting data for “The Protective Role of Tubular β-catenin in Acute Kidney Injury”

description: Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction in chronic kidney fibrosis, little is known of the influence of β-catenin on mitochondrial function in AKI. To decipher this interaction, we generated an inducible mouse model of tubule-specific β-catenin overexpression (TubCat), and a model of tubule-specific β-catenin depletion (TubcatKO), and induced septic AKI in these mice with lipopolysaccharide (LPS) and aseptic AKI with bilateral ischemia-reperfusion. In both AKI models, tubular β-catenin stabilization in TubCat animals significantly reduced BUN/serum creatinine, tubular damage (NGAL-positive tubules), apoptosis (TUNEL-positive cells) and necroptosis (phosphorylation of MLKL and RIP3) through activating AKT phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased PGC-1α and NRF1) and restored mitochondrial mass (increased TIM23) to re-establish mitochondrial homeostasis (increased fusion markers OPA1, MFN2, and decreased fission protein DRP1) through the FOXO3/PGC-1α signaling cascade. Conversely, kidney function loss and histological damage, tubular cell death, and mitochondrial dysfunction were all aggravated in TubCatKO mice. Mechanistically, β-catenin transfection maintained mitochondrial mass and activated PGC-1α via FOXO3 in LPS-exposed HK-2 cells. Taken together, these findings provide evidence that tubular β-catenin mitigates cell death and restores mitochondrial homeostasis in AKI through the common mechanisms associated with activation of AKT/p53 and FOXO3/PGC-1α signaling pathways.
DOI: 10.15151/esrf-es-744171909
title: High entropy rare-earth ortho-niobates

description: High entropy oxides are one the most interesting new groups of ceramics. Their complex properties are interesting both from basic research and application point of view. Our previous work focused on the properties of proton conductors with low entropy. The current project aims on understanding of the relation of high configurational entropy of rare-earth ortho-niobates and their crystalline and electronic structure. The measurement of x-ray absorption will possibly reveal the relation between the cation composition and unoccupied electron densities for studied materials, this can be then linked to the materials electrochemical performance, ionic conductivity, and proton uptake. This will lead both to a better understanding of phenomena occurring in these materials but also will allow tailoring materials with desired properties for applications in proton-conducting cells.
DOI: 10.6084/m9.figshare.19646209
title: Additional file 2 of Development of the Clinical Gestalt Assessment: a visual clinical global impression scale for Proteus syndrome

description: Additional file 2: Table S1. Chronology key and rater responses.
DOI: 10.6084/m9.figshare.19646209.v1
title: Additional file 2 of Development of the Clinical Gestalt Assessment: a visual clinical global impression scale for Proteus syndrome

description: Additional file 2: Table S1. Chronology key and rater responses.
DOI: 10.5281/zenodo.6482346
title: SROADEX: Dataset for binary recognition and semantic segmentation of road surface areas from high resolution Aerial Orthoimages Covering Approximately 8,650 km2 of the Spanish Territory Tagged with Road Information

description: The data have been generated using scripts developed in Python using Open Source libraries (GDAL/OGR and MapScript) for rasterization of vector cartography representing the axes of the different types of roads (urban, interurban and rural). This cartography has been obtained from different Spanish official sources (National Geographic Institute and autonomic cartographic agencies) that we have revised and edited in a meticulous and systematic way to verify that the roads are represented on the cartography according to the orthoimages, available on January 1, 2021 in the download center of the National Center of Geographic Information (CNIG), on 16 rectangular areas (28,5 km * 18,5 km) of the Spanish territory (insular and peninsular). The dataset consists of 777599 images in png format of 256x256 pixels, organized in folders for the different trainings, separating those corresponding to training, testing and validation. The structure of the data is as follows:<br> 1-Road-Ortho and 1-Road-Mask contain the images and ground true for training the semantic segmentation networks.<br> 1-Road-Ortho and 2-NoRoad-Ortho contain aerial images containing or not containing vials, for the training of binary tessellation networks identifying tessellations with vials.<br> Moreover, in each folder the structure is the same: train, test, validation containing 90%, 5% and 5% of the total images and masks of each type. 1-Road-Ortho |----Train |----Test -----Validation 1-Road-Mask |----Train |----Test -----Validation 2-NoRoad-Ortho |----Train |----Test -----Validation
description: Grant PID2020-116448GB-I00, funded by the Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación (ES)
DOI: 10.5281/zenodo.5905849
title: SROADEX: Dataset for binary recognition and semantic segmentation of road surface areas from high resolution Aerial Orthoimages Covering Approximately 8,650 km2 of the Spanish Territory Tagged with Road Information

description: The data have been generated using scripts developed in Python using Open Source libraries (GDAL/OGR and MapScript) for rasterization of vector cartography representing the axes of the different types of roads (urban, interurban and rural). This cartography has been obtained from different Spanish official sources (National Geographic Institute and autonomic cartographic agencies) that we have revised and edited in a meticulous and systematic way to verify that the roads are represented on the cartography according to the orthoimages, available on January 1, 2021 in the download center of the National Center of Geographic Information (CNIG), on 16 rectangular areas (28,5 km * 18,5 km) of the Spanish territory (insular and peninsular). The dataset consists of 777599 images in png format of 256x256 pixels, organized in folders for the different trainings, separating those corresponding to training, testing and validation. The structure of the data is as follows:<br> 1-Road-Ortho and 1-Road-Mask contain the images and ground true for training the semantic segmentation networks.<br> 1-Road-Ortho and 2-NoRoad-Ortho contain aerial images containing or not containing vials, for the training of binary tessellation networks identifying tessellations with vials.<br> Moreover, in each folder the structure is the same: train, test, validation containing 90%, 5% and 5% of the total images and masks of each type. 1-Road-Ortho |----Train |----Test -----Validation 1-Road-Mask |----Train |----Test -----Validation 2-NoRoad-Ortho |----Train |----Test -----Validation
description: Grant PID2020-116448GB-I00, funded by the Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación (ES)
DOI: 10.6084/m9.figshare.19646254
title: Additional file 1 of Vascular function of the T3/modern clade WUSCHEL-Related HOMEOBOX transcription factor genes predate apical meristem-maintenance function

description: Additional file 1.