cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21545897.v1
title: OSTEOTOMY AT THE BASE OF FEMORAL NECK AND OSTEOPLASTY FOR THE TREAMENT OF SCFE

description: ABSTRACT Objective: To compare the clinical outcomes between patients with moderate and severe slipped capital femoral epiphysis (SCFE) treated with osteotomy at the base of neck and osteoplasty and with healthy individuals. Methods: Comparative cohort with 12 patients (14 hips) with moderate and severe SCFE who underwent osteotomy at the base of neck and osteoplasty between 2007 and 2014. The mean age at surgery was 13.3 ± 2.5 years and the mean follow-up was 3.8 ± 2.2 years. We assessed the level of hip pain by the visual analog scale (VAS) and anterior impingement test (AIT); the level of function using the Harris Hip Score (HHS) and 12-Item Short Form Health Survey (SF-12), the range of motion (ROM) by goniometry and Drehmann sign, and the hip muscular strength by isokinetic and Trendelenburg sign. Results: The level of pain was slightly higher in the SCFE cohort compared with healthy hips (VAS, 0.8 ± 1.4 vs 0 ± 0, 0.007; AIT, 14% vs 0%, p = 0.06; respectively). No differences were observed between the SCFE and control cohort for the functional scores (HHS, 94 ± 7 vs 100 ± 1, p = 0.135); except for ROM, with increased internal rotation (37.3º ± 9.4º vs 28.7º ± 8.2º, p &lt; 0.001), and strength, with decreased abduction torque (75.5 ± 36.9 Nm/Kg vs 88.5 ± 27.6 Nm/Kg, p = 0.045) in the SCFE cohort. Conclusion: The osteotomy at the base of neck and the osteoplasty restored the hip motion and muscle strength, except for the abductor strength, to near normal levels, representing a viable option for the treatment of moderate and severe SCFE. Level of Evidence III, Ambidirectional Cohort Study.
DOI: 10.6084/m9.figshare.20134171
title: Nonnegative principal component analysis in thin layer fingerprint screening: A case of <i>Gentiana</i> extracts from <i>in vitro</i> cultures

description: Twenty-one species of Gentiana L. were successfully grown <i>in vitro</i> in the same conditions and 72 samples of various cultures of these species (root, shoots, cotyledon callus, hypocotyl callus, and root callus) were obtained. The investigated species were as follows: <i>G. affinis</i>, <i>G. andrewsii</i>, <i>G. bhutanica</i>, <i>G. burseri</i>, <i>G. cachemirica</i>, <i>G. capitata</i>, <i>G. crassicaulis</i>, <i>G. dahurica</i>, <i>G. decumbens</i>, <i>G. freyniana</i>, <i>G. frigida</i>, <i>G. gelida</i>, <i>G. grossheimii</i>, <i>G. kurroo</i>, <i>G. macrophylla</i>, <i>G. paradoxa</i>, <i>G. robusta</i>, <i>G. scabra</i>, <i>G. septemfida</i>, <i>G. siphonantha</i>, and <i>G. tianschanica</i>. The obtained samples were extracted with methanol–acetone–water (3:1:1) mixture, evaporated to dryness, and subjected to TLC on silica gel with mobile phase ethyl acetate–methanol–water (8:2:2) in sandwich mode. Data fusion of two densitometric modes: extinction at 254 nm and fluorescence at 312 nm (emission above 370 nm) were used as a fingerprint of each sample. Densitograms were denoised, subjected to baseline removal, warped, and analyzed with principal component analysis (PCA), hierarchical cluster analysis and—the novel proposal—nonnegative PCA. This allowed to split negatively intercorrelated fingerprint features to subsequent principal components (PCs), which increases the number of PCs required to see the same information, but these PCs are much more informative.
DOI: 10.6084/m9.figshare.20134171.v1
title: Nonnegative principal component analysis in thin layer fingerprint screening: A case of <i>Gentiana</i> extracts from <i>in vitro</i> cultures

description: Twenty-one species of Gentiana L. were successfully grown <i>in vitro</i> in the same conditions and 72 samples of various cultures of these species (root, shoots, cotyledon callus, hypocotyl callus, and root callus) were obtained. The investigated species were as follows: <i>G. affinis</i>, <i>G. andrewsii</i>, <i>G. bhutanica</i>, <i>G. burseri</i>, <i>G. cachemirica</i>, <i>G. capitata</i>, <i>G. crassicaulis</i>, <i>G. dahurica</i>, <i>G. decumbens</i>, <i>G. freyniana</i>, <i>G. frigida</i>, <i>G. gelida</i>, <i>G. grossheimii</i>, <i>G. kurroo</i>, <i>G. macrophylla</i>, <i>G. paradoxa</i>, <i>G. robusta</i>, <i>G. scabra</i>, <i>G. septemfida</i>, <i>G. siphonantha</i>, and <i>G. tianschanica</i>. The obtained samples were extracted with methanol–acetone–water (3:1:1) mixture, evaporated to dryness, and subjected to TLC on silica gel with mobile phase ethyl acetate–methanol–water (8:2:2) in sandwich mode. Data fusion of two densitometric modes: extinction at 254 nm and fluorescence at 312 nm (emission above 370 nm) were used as a fingerprint of each sample. Densitograms were denoised, subjected to baseline removal, warped, and analyzed with principal component analysis (PCA), hierarchical cluster analysis and—the novel proposal—nonnegative PCA. This allowed to split negatively intercorrelated fingerprint features to subsequent principal components (PCs), which increases the number of PCs required to see the same information, but these PCs are much more informative.
DOI: 10.6084/m9.figshare.21545927.v1
title: MORTALITY AFTER SURGICAL TREATMENT OF PROXIMAL HUMERUS FRACTURES IN OLDER PATIENTS

description: ABSTRACT Mortality of patients after osteosynthesis of proximal humeral fractures (PHF) has been poorly studied in contrast to fractures of the proximal femur. Objective: To evaluate the mortality of older patients with PHF undergoing surgical treatment. Methods: Retrospective study of patients undergoing surgical treatment PHF between 2009-2019. Demographic data, Neer classification, and mortality of this cohort of patients were evaluated. Non-categorical variables were tested using the Kolmogorov-Smirnov test. The unpaired t-test (parametric variables) was used. Categorical variables were tested by Fisher’s exact test. A Kaplan-Meier mortality curve was constructed. Results: 59 patients were evaluated. There was a predominance of females in the sixth decade of life. The most prevalent fractures were Neer’s type III. The highest mortality occurred in the first 4 years after surgery (4.1 + 3.2 years). The only comorbidity capable of changing the survival curve was DM (p = 0.03) Conclusion: Overall mortality was 11.3%. The highest mortality occurred in the first 4 years of follow-up. Diabetic patients evolve with earlier mortality and have 7 times more chance of death. Level of Evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.21545927
title: MORTALITY AFTER SURGICAL TREATMENT OF PROXIMAL HUMERUS FRACTURES IN OLDER PATIENTS

description: ABSTRACT Mortality of patients after osteosynthesis of proximal humeral fractures (PHF) has been poorly studied in contrast to fractures of the proximal femur. Objective: To evaluate the mortality of older patients with PHF undergoing surgical treatment. Methods: Retrospective study of patients undergoing surgical treatment PHF between 2009-2019. Demographic data, Neer classification, and mortality of this cohort of patients were evaluated. Non-categorical variables were tested using the Kolmogorov-Smirnov test. The unpaired t-test (parametric variables) was used. Categorical variables were tested by Fisher’s exact test. A Kaplan-Meier mortality curve was constructed. Results: 59 patients were evaluated. There was a predominance of females in the sixth decade of life. The most prevalent fractures were Neer’s type III. The highest mortality occurred in the first 4 years after surgery (4.1 + 3.2 years). The only comorbidity capable of changing the survival curve was DM (p = 0.03) Conclusion: Overall mortality was 11.3%. The highest mortality occurred in the first 4 years of follow-up. Diabetic patients evolve with earlier mortality and have 7 times more chance of death. Level of Evidence III, Retrospective Study.
DOI: 10.6084/m9.figshare.21545936
title: The greenway for bridge column rehabilitation: a comparison between different techniques based on multi-criteria decision analysis

description: Abstract One of the biggest issues in civil engineering is the poor performance of concrete repairs. In fact, in Europe only 50% of concrete structures restorations are estimated to be successful, even though rehabilitation costs account for about half of the yearly construction budgets. This research aims at investigating a potential green approach to the sustainability of rehabilitation solutions for infrastructures. Following a simplified analysis of C02 emissions, intervention costs, social aspects, structural performances and other variables considered relevant to the scope, possible rehabilitation techniques are compared and ranked. The following four different options have therefore been designed to be applied to an actual column of the Brabau Bridge in Sardinia (Italy): i. complete removal and replacement of the column, ii. replacement of the damaged longitudinal rebars by machined bars and ultra-high performance fibre-reinforced concrete (UHPFRC) strengthening, iii. longitudinal and transverse fiber reinforced polymers (FRP) wrapping, iv. concrete jacketing. A methodological and procedural strategy is established through multi-criteria analysis that will allow future developments to assess the whole Life Cycle Assessment of the maintenance work.
DOI: 10.6084/m9.figshare.21545936.v1
title: The greenway for bridge column rehabilitation: a comparison between different techniques based on multi-criteria decision analysis

description: Abstract One of the biggest issues in civil engineering is the poor performance of concrete repairs. In fact, in Europe only 50% of concrete structures restorations are estimated to be successful, even though rehabilitation costs account for about half of the yearly construction budgets. This research aims at investigating a potential green approach to the sustainability of rehabilitation solutions for infrastructures. Following a simplified analysis of C02 emissions, intervention costs, social aspects, structural performances and other variables considered relevant to the scope, possible rehabilitation techniques are compared and ranked. The following four different options have therefore been designed to be applied to an actual column of the Brabau Bridge in Sardinia (Italy): i. complete removal and replacement of the column, ii. replacement of the damaged longitudinal rebars by machined bars and ultra-high performance fibre-reinforced concrete (UHPFRC) strengthening, iii. longitudinal and transverse fiber reinforced polymers (FRP) wrapping, iv. concrete jacketing. A methodological and procedural strategy is established through multi-criteria analysis that will allow future developments to assess the whole Life Cycle Assessment of the maintenance work.
DOI: 10.6084/m9.figshare.21545937
title: Use of platelet-rich fibrin for bone repair: a systematic review and meta-analysis of preclinical studies

description: Abstract This systematic review evaluated the potential utility of platelet-rich fibrin (PRF) in bone repair in animals. The question is: can the use of PRF in bone defects in healthy rats induce bone repair compared to clot? This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma). The protocol was registered with Prospero (CRD [42020162319]). The literature search involved nine databases, including grey literature. All studies evaluated the bone defects created in rats filled with PRF and clots (control). Biomaterial evaluation was also performed in this study. The risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (Syrcle) tool for animal studies. A meta-analysis of quantitative data was performed to estimate the effect of PRF on bone repair in rats. Heterogeneity among the studies was assessed using the I2 statistic. The literature search retrieved 685 studies, 10 of which fulfilled the eligibility criteria, and 4 were included in the quantitative assessment. Analysis of the risk of bias revealed that most studies had a high risk of bias in performance and detection. Meta-analysis yielded divergent results and the absence of a statistically significant effect: PRF with control (standardized mean difference 2.54, 95% confidence interval -0.80–5.89; p = 0.14). In general, study heterogeneity was high (I2 ≥ 75.0%). The quality of the studies that influenced the conclusion of the review was based on the PICO, the sources and form of the search, the study selection criteria, the form of evaluation of publication bias, the evaluation of the quality of the studies, and data extraction by two researchers. PRF did not provide significant benefits for bone repair, resulting in unpredictable effects.
DOI: 10.6084/m9.figshare.21545937.v1
title: Use of platelet-rich fibrin for bone repair: a systematic review and meta-analysis of preclinical studies

description: Abstract This systematic review evaluated the potential utility of platelet-rich fibrin (PRF) in bone repair in animals. The question is: can the use of PRF in bone defects in healthy rats induce bone repair compared to clot? This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma). The protocol was registered with Prospero (CRD [42020162319]). The literature search involved nine databases, including grey literature. All studies evaluated the bone defects created in rats filled with PRF and clots (control). Biomaterial evaluation was also performed in this study. The risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (Syrcle) tool for animal studies. A meta-analysis of quantitative data was performed to estimate the effect of PRF on bone repair in rats. Heterogeneity among the studies was assessed using the I2 statistic. The literature search retrieved 685 studies, 10 of which fulfilled the eligibility criteria, and 4 were included in the quantitative assessment. Analysis of the risk of bias revealed that most studies had a high risk of bias in performance and detection. Meta-analysis yielded divergent results and the absence of a statistically significant effect: PRF with control (standardized mean difference 2.54, 95% confidence interval -0.80–5.89; p = 0.14). In general, study heterogeneity was high (I2 ≥ 75.0%). The quality of the studies that influenced the conclusion of the review was based on the PICO, the sources and form of the search, the study selection criteria, the form of evaluation of publication bias, the evaluation of the quality of the studies, and data extraction by two researchers. PRF did not provide significant benefits for bone repair, resulting in unpredictable effects.
DOI: 10.6084/m9.figshare.21506000
title: The role of cladocerans in green and brown food web coupling

description: ABSTRACT Cladocerans, an important zooplankton community, are consumers from the base of the food web of aquatic environments. We investigated the contribution of producers (phytoplankton and periphytic biofilm) and particulate organic carbon (POC). Collections were carried out in lakes of the Upper Paraná River Floodplain, the last stretch free of dams in the second-largest South American basin. Isotope ratios (δ13C and δ15N) were measured, besides the contributions of probable food sources to the cladocerans biomass. The phytoplankton constituted the source of carbon for cladocerans, followed by POC. Thus this work, in addition to emphasizing the importance of cladocerans in nutrient cycling, highlighted the need for the conservation of environments surrounding the lakes as they are the sources of organic matter for aquatic communities. Besides, the analyzed zooplanktonic organisms demonstrated their role in the interconnection between the green and brown food webs, which have been studied separately for a long time.
DOI: 10.6084/m9.figshare.21506000.v1
title: The role of cladocerans in green and brown food web coupling

description: ABSTRACT Cladocerans, an important zooplankton community, are consumers from the base of the food web of aquatic environments. We investigated the contribution of producers (phytoplankton and periphytic biofilm) and particulate organic carbon (POC). Collections were carried out in lakes of the Upper Paraná River Floodplain, the last stretch free of dams in the second-largest South American basin. Isotope ratios (δ13C and δ15N) were measured, besides the contributions of probable food sources to the cladocerans biomass. The phytoplankton constituted the source of carbon for cladocerans, followed by POC. Thus this work, in addition to emphasizing the importance of cladocerans in nutrient cycling, highlighted the need for the conservation of environments surrounding the lakes as they are the sources of organic matter for aquatic communities. Besides, the analyzed zooplanktonic organisms demonstrated their role in the interconnection between the green and brown food webs, which have been studied separately for a long time.
DOI: 10.6084/m9.figshare.21545940
title: Risk factors for jaw osteoradionecrosis: a case control study

description: Abstract There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development.
DOI: 10.6084/m9.figshare.21545940.v1
title: Risk factors for jaw osteoradionecrosis: a case control study

description: Abstract There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development.
DOI: 10.6084/m9.figshare.21505901
title: Influence of rainfall regime in the Cerrado biome on the maintenance of traps built by Myrmeleon brasiliensis (Navás) (Neuroptera: Myrmeleontidae) larvae and the morphology of adults

description: ABSTRACT Seasonality in the Cerrado biome of Brazil is characterized by a dry season and a rainy season, affecting the availability of water and generating nutritional limitations. Thus, plants and animals have developed adaptive mechanisms in order to survive in this environment. Insects known as antlions (Neuroptera: Myrmeleontidae) occur in areas of the Cerrado and build traps in dry soil to capture prey items. In the rainy season, these insects are unable to forage due to the waterlogged soil. The aim of this study was to investigate the influence of the rainfall regime in the Cerrado on aspects of trap-building behavior, larval development and morphological characteristics of adult antlions. Larvae of the antlion Myrmeleon brasiliensis (Návas, 1914) were observed and collected in an area of the Cerrado biome in the municipality of Aquidauana (MS), Brazil. Observations were performed in the rainy and dry seasons to determine the abundance of traps built by M. brasiliensis larvae. In the laboratory, experiments were performed involving the manipulation of the frequency of simulated rain on the traps. The results revealed that variations in rainfall due to seasonality in the Cerrado affect M. brasiliensis larvae, with greater foraging observed in the dry season. The laboratory experiments demonstrated that differences in the frequency of rains affect the mortality of the larvae, larval development time and the size of the adults. Thus, variations in rainfall patterns can lead to variations in the characteristics of the population structure of M. brasiliensis in areas of the Cerrado biome in Brazil.
DOI: 10.6084/m9.figshare.21505901.v1
title: Influence of rainfall regime in the Cerrado biome on the maintenance of traps built by Myrmeleon brasiliensis (Navás) (Neuroptera: Myrmeleontidae) larvae and the morphology of adults

description: ABSTRACT Seasonality in the Cerrado biome of Brazil is characterized by a dry season and a rainy season, affecting the availability of water and generating nutritional limitations. Thus, plants and animals have developed adaptive mechanisms in order to survive in this environment. Insects known as antlions (Neuroptera: Myrmeleontidae) occur in areas of the Cerrado and build traps in dry soil to capture prey items. In the rainy season, these insects are unable to forage due to the waterlogged soil. The aim of this study was to investigate the influence of the rainfall regime in the Cerrado on aspects of trap-building behavior, larval development and morphological characteristics of adult antlions. Larvae of the antlion Myrmeleon brasiliensis (Návas, 1914) were observed and collected in an area of the Cerrado biome in the municipality of Aquidauana (MS), Brazil. Observations were performed in the rainy and dry seasons to determine the abundance of traps built by M. brasiliensis larvae. In the laboratory, experiments were performed involving the manipulation of the frequency of simulated rain on the traps. The results revealed that variations in rainfall due to seasonality in the Cerrado affect M. brasiliensis larvae, with greater foraging observed in the dry season. The laboratory experiments demonstrated that differences in the frequency of rains affect the mortality of the larvae, larval development time and the size of the adults. Thus, variations in rainfall patterns can lead to variations in the characteristics of the population structure of M. brasiliensis in areas of the Cerrado biome in Brazil.