cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22548254.v1
title: Rivaroxaban in Outpatients with Mild or Moderate COVID-19: Rationale and Design of the Study CARE (CARE – Coalition COVID-19 Brazil VIII)

description: Abstract Background Previous studies have demonstrated a high risk of arterial and venous thromboembolic events as a consequence of direct viral damage to endothelial cells by SARS-CoV-2 and a procoagulant milieu due to increased biomarkers, such as D-dimer, fibrinogen, and factor VIII. Although randomized controlled trials of antithrombotic therapies have been conducted in hospitalized patients, few have evaluated the role of thromboprophylaxis in an outpatient setting. Objective To assess whether antithrombotic prophylaxis with rivaroxaban reduces the risk of venous or arterial thrombotic events, invasive ventilatory support, and death in COVID-19 outpatients. Methods The COVID Antithrombotic Rivaroxaban Evaluation (CARE) study, a multicenter, randomized, open-label, controlled trial of rivaroxaban 10 mg once daily for 14 days or local standard treatment alone to prevent adverse outcomes, is registered in clinicaltrials.gov (NCT04757857). The inclusion criteria are adults with confirmed or suspected SARS-CoV-2 infection and mild or moderate symptoms without indication for hospitalization, within 7 days of symptom onset, and 1 risk factor for COVID-19 complication (&gt; 65 years, hypertension, diabetes mellitus, asthma, chronic obstructive pulmonary disease or other chronic lung diseases, smoking, immunosuppression, or obesity). The primary composite endpoint, which includes venous thromboembolism, invasive mechanical ventilation, major acute cardiovascular events, and mortality within 30 days of randomization, will be assessed according to the intention-to-treat principle. All patients will provide informed consent. A significance level of 5% will be used for all statistical tests. Results Major thrombotic and bleeding outcomes, hospitalizations, and deaths will be centrally adjudicated by an independent clinical events committee blinded to the assigned treatment groups. Conclusion The CARE study will provide relevant and contemporary information about the potential role of thromboprophylaxis in outpatients with COVID-19.
DOI: 10.6084/m9.figshare.22548254
title: Rivaroxaban in Outpatients with Mild or Moderate COVID-19: Rationale and Design of the Study CARE (CARE – Coalition COVID-19 Brazil VIII)

description: Abstract Background Previous studies have demonstrated a high risk of arterial and venous thromboembolic events as a consequence of direct viral damage to endothelial cells by SARS-CoV-2 and a procoagulant milieu due to increased biomarkers, such as D-dimer, fibrinogen, and factor VIII. Although randomized controlled trials of antithrombotic therapies have been conducted in hospitalized patients, few have evaluated the role of thromboprophylaxis in an outpatient setting. Objective To assess whether antithrombotic prophylaxis with rivaroxaban reduces the risk of venous or arterial thrombotic events, invasive ventilatory support, and death in COVID-19 outpatients. Methods The COVID Antithrombotic Rivaroxaban Evaluation (CARE) study, a multicenter, randomized, open-label, controlled trial of rivaroxaban 10 mg once daily for 14 days or local standard treatment alone to prevent adverse outcomes, is registered in clinicaltrials.gov (NCT04757857). The inclusion criteria are adults with confirmed or suspected SARS-CoV-2 infection and mild or moderate symptoms without indication for hospitalization, within 7 days of symptom onset, and 1 risk factor for COVID-19 complication (&gt; 65 years, hypertension, diabetes mellitus, asthma, chronic obstructive pulmonary disease or other chronic lung diseases, smoking, immunosuppression, or obesity). The primary composite endpoint, which includes venous thromboembolism, invasive mechanical ventilation, major acute cardiovascular events, and mortality within 30 days of randomization, will be assessed according to the intention-to-treat principle. All patients will provide informed consent. A significance level of 5% will be used for all statistical tests. Results Major thrombotic and bleeding outcomes, hospitalizations, and deaths will be centrally adjudicated by an independent clinical events committee blinded to the assigned treatment groups. Conclusion The CARE study will provide relevant and contemporary information about the potential role of thromboprophylaxis in outpatients with COVID-19.
DOI: 10.6084/m9.figshare.22337794
title: Supplementary Material 3 - Code project in R (zipped) from Pests or prey? Micromammal species within an ancient anthropic environment at the norse settlement site of Tuquoy (Westray, Orkney)

description: Zip file containing an R scripting project, used to derive correlation data and visualisations.
DOI: 10.6084/m9.figshare.22337797
title: Supplementary Material 1 - Data Tables from Pests or prey? Micromammal species within an ancient anthropic environment at the norse settlement site of Tuquoy (Westray, Orkney)

description: Excel file with five tables containing Tuquoy micromammal data (four tables) and references from Andrews 1990 (one table).
DOI: 10.6084/m9.figshare.22337797.v3
title: Supplementary Material 1 - Data Tables from Pests or prey? Micromammal species within an ancient anthropic environment at the Norse settlement site of Tuquoy (Westray, Orkney)

description: Excel file with five tables containing Tuquoy micromammal data (four tables) and references from Andrews 1990 (one table).
DOI: 10.6084/m9.figshare.22548257.v1
title: Reproducibility of linear and angular cephalometric measurements obtained by an artificial-intelligence assisted software (WebCeph) in comparison with digital software (AutoCEPH) and manual tracing method

description: ABSTRACT Introduction: It has been suggested that human errors during manual tracing of linear/angular cephalometric parameters can be eliminated by using computer-aided analysis. The landmarks, however, are located manually and the computer system completes the analysis. With the advent of Artificial Intelligence in the field of Dentistry, automatic location of the landmarks has become a promising tool in digital Orthodontics. Methods: Fifty pretreatment lateral cephalograms obtained from the Orthodontic department of SRM dental college (India) were used. Analysis were done by the same investigator using the following methods: WebCeph™, AutoCEPH© for Windows or manual tracing. Landmark identification was carried out automatically by Artificial Intelligence in WebCeph™ and with a mouse driven cursor in AutoCEPH©, and manually using acetate sheet and 0.3-mm pencil, ruler and a protractor. The mean differences of the cephalometric parameters obtained between the three methods were calculated using ANOVA with statistical significance set at p&lt;0.05. Intraclass correlation coefficient (ICC) was used to determine both reproducibility and agreement between linear and angular measurements obtained from the three methods and intrarater reliability of repeated measurements. ICC value of &gt;0.75 indicated good agreement. Results: Intraclass correlation coefficient between the three groups was &gt;0.830, showing good level of agreement, and the value within each group was &gt;0.950, indicating high intrarater reliability. Conclusion: Artificial Intelligence assisted software showed good agreement with AutoCEPH© and manual tracing for all the cephalometric measurements.
DOI: 10.6084/m9.figshare.22548257
title: Reproducibility of linear and angular cephalometric measurements obtained by an artificial-intelligence assisted software (WebCeph) in comparison with digital software (AutoCEPH) and manual tracing method

description: ABSTRACT Introduction: It has been suggested that human errors during manual tracing of linear/angular cephalometric parameters can be eliminated by using computer-aided analysis. The landmarks, however, are located manually and the computer system completes the analysis. With the advent of Artificial Intelligence in the field of Dentistry, automatic location of the landmarks has become a promising tool in digital Orthodontics. Methods: Fifty pretreatment lateral cephalograms obtained from the Orthodontic department of SRM dental college (India) were used. Analysis were done by the same investigator using the following methods: WebCeph™, AutoCEPH© for Windows or manual tracing. Landmark identification was carried out automatically by Artificial Intelligence in WebCeph™ and with a mouse driven cursor in AutoCEPH©, and manually using acetate sheet and 0.3-mm pencil, ruler and a protractor. The mean differences of the cephalometric parameters obtained between the three methods were calculated using ANOVA with statistical significance set at p&lt;0.05. Intraclass correlation coefficient (ICC) was used to determine both reproducibility and agreement between linear and angular measurements obtained from the three methods and intrarater reliability of repeated measurements. ICC value of &gt;0.75 indicated good agreement. Results: Intraclass correlation coefficient between the three groups was &gt;0.830, showing good level of agreement, and the value within each group was &gt;0.950, indicating high intrarater reliability. Conclusion: Artificial Intelligence assisted software showed good agreement with AutoCEPH© and manual tracing for all the cephalometric measurements.
DOI: 10.6084/m9.figshare.22548261.v1
title: Dissemination... of what kind of science? Reflections on the representation of scientists in the journal Ciência Hoje das Crianças

description: Abstract: This study aimed to analyze the representations of scientists present in the journal Ciência Hoje das Crianças (CHC). The research presents a qualitative approach and documentary typology. The content analysis framework was used, from which three categories emerged: individualist-elitist, gender-position, and origin. Based on the analyses, it was possible to infer that the CHC journal presents a duality in its representations, given that it still brings in its content elitist and individualistic examples of scientists, there are also examples with plurality of bodies, genders, etc. Finally, it is important to highlight that the CHC journal is important for science teaching that directly contributes to the construction of an imaginary about scientists for those who read it. Thus, it becomes a fundamental space for breaking paradigms that have long been perpetuated in Scientific Dissemination materials.
DOI: 10.6084/m9.figshare.22548261
title: Dissemination... of what kind of science? Reflections on the representation of scientists in the journal Ciência Hoje das Crianças

description: Abstract: This study aimed to analyze the representations of scientists present in the journal Ciência Hoje das Crianças (CHC). The research presents a qualitative approach and documentary typology. The content analysis framework was used, from which three categories emerged: individualist-elitist, gender-position, and origin. Based on the analyses, it was possible to infer that the CHC journal presents a duality in its representations, given that it still brings in its content elitist and individualistic examples of scientists, there are also examples with plurality of bodies, genders, etc. Finally, it is important to highlight that the CHC journal is important for science teaching that directly contributes to the construction of an imaginary about scientists for those who read it. Thus, it becomes a fundamental space for breaking paradigms that have long been perpetuated in Scientific Dissemination materials.
DOI: 10.6084/m9.figshare.22548266
title: Permanent Education in Health and prison system actors in the pandemic scenario

description: Abstract Permanent Education in Health legitimized health education based on meaningful learning, experiences in daily work and collective problem solving, in addition to being based on the four-way approach, based on teaching, management, attention and social control. The COVID-19 pandemic has required new ways of doing health and education, especially in the prison system, where overcrowding is an impediment to social isolation. This study aimed to identify, through virtual conversation circles, the challenges encountered in daily work and discuss proposals for intervention with the actors of the prison system in the pandemic period, from the perspective of Permanent Education in Health. It was used a qualitative research approach with descriptive, interpretative and comprehensive analysis of the social phenomenon, through Minayo’s thematic analysis of content. From the thematic analysis of content, four categories emerged: challenges of health care in the prison system in the context of the COVID-19 pandemic; challenges for health management in prisons; dialogue between educational institutions and the prison system; and social control and family representation. The virtual conversation rounds provided in-depth discussions and collective constructions, proposing referrals based on the four-way approach of Permanent Education in Health.
DOI: 10.6084/m9.figshare.22548263.v1
title: Anxiety, depression, and memory loss in Chagas disease: a puzzle far beyond neuroinflammation to be unpicked and solved*

description: Mental disorders such as anxiety, depression, and memory loss have been described in patients with chronic Chagas disease (CD), a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. Social, psychological, and biological stressors may take part in these processes. There is a consensus on the recognition of an acute nervous form of CD. In chronic CD patients, a neurological form is associated with immunosuppression and neurobehavioural changes as sequelae of stroke. The chronic nervous form of CD has been refuted, based on the absence of histopathological lesions and neuroinflammation; however, computed tomography shows brain atrophy. Overall, in preclinical models of chronic T. cruzi infection in the absence of neuroinflammation, behavioural disorders such as anxiety and depression, and memory loss are related to brain atrophy, parasite persistence, oxidative stress, and cytokine production in the central nervous system. Interferon-gamma (IFNγ)-bearing microglial cells are colocalised with astrocytes carrying T. cruzi amastigote forms. In vitro studies suggest that IFNγ fuels astrocyte infection by T. cruzi and implicate IFNγ-stimulated infected astrocytes as sources of TNF and nitric oxide, which may also contribute to parasite persistence in the brain tissue and promote behavioural and neurocognitive changes. Preclinical trials in chronically infected mice targeting the TNF pathway or the parasite opened paths for therapeutic approaches with a beneficial impact on depression and memory loss. Despite the path taken, replicating aspects of the chronic CD and testing therapeutic schemes in preclinical models, these findings may get lost in translation as the chronic nervous form of CD does not fulfil biomedical model requirements, as the presence of neuroinflammation, to be recognised. It is hoped that brain atrophy and behavioural and neurocognitive changes are sufficient traits to bring the attention of researchers to study the biological and molecular basis of the central nervous system commitment in chronic CD.
DOI: 10.6084/m9.figshare.22548263
title: Anxiety, depression, and memory loss in Chagas disease: a puzzle far beyond neuroinflammation to be unpicked and solved*

description: Mental disorders such as anxiety, depression, and memory loss have been described in patients with chronic Chagas disease (CD), a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. Social, psychological, and biological stressors may take part in these processes. There is a consensus on the recognition of an acute nervous form of CD. In chronic CD patients, a neurological form is associated with immunosuppression and neurobehavioural changes as sequelae of stroke. The chronic nervous form of CD has been refuted, based on the absence of histopathological lesions and neuroinflammation; however, computed tomography shows brain atrophy. Overall, in preclinical models of chronic T. cruzi infection in the absence of neuroinflammation, behavioural disorders such as anxiety and depression, and memory loss are related to brain atrophy, parasite persistence, oxidative stress, and cytokine production in the central nervous system. Interferon-gamma (IFNγ)-bearing microglial cells are colocalised with astrocytes carrying T. cruzi amastigote forms. In vitro studies suggest that IFNγ fuels astrocyte infection by T. cruzi and implicate IFNγ-stimulated infected astrocytes as sources of TNF and nitric oxide, which may also contribute to parasite persistence in the brain tissue and promote behavioural and neurocognitive changes. Preclinical trials in chronically infected mice targeting the TNF pathway or the parasite opened paths for therapeutic approaches with a beneficial impact on depression and memory loss. Despite the path taken, replicating aspects of the chronic CD and testing therapeutic schemes in preclinical models, these findings may get lost in translation as the chronic nervous form of CD does not fulfil biomedical model requirements, as the presence of neuroinflammation, to be recognised. It is hoped that brain atrophy and behavioural and neurocognitive changes are sufficient traits to bring the attention of researchers to study the biological and molecular basis of the central nervous system commitment in chronic CD.
DOI: 10.6084/m9.figshare.22548266.v1
title: Permanent Education in Health and prison system actors in the pandemic scenario

description: Abstract Permanent Education in Health legitimized health education based on meaningful learning, experiences in daily work and collective problem solving, in addition to being based on the four-way approach, based on teaching, management, attention and social control. The COVID-19 pandemic has required new ways of doing health and education, especially in the prison system, where overcrowding is an impediment to social isolation. This study aimed to identify, through virtual conversation circles, the challenges encountered in daily work and discuss proposals for intervention with the actors of the prison system in the pandemic period, from the perspective of Permanent Education in Health. It was used a qualitative research approach with descriptive, interpretative and comprehensive analysis of the social phenomenon, through Minayo’s thematic analysis of content. From the thematic analysis of content, four categories emerged: challenges of health care in the prison system in the context of the COVID-19 pandemic; challenges for health management in prisons; dialogue between educational institutions and the prison system; and social control and family representation. The virtual conversation rounds provided in-depth discussions and collective constructions, proposing referrals based on the four-way approach of Permanent Education in Health.
DOI: 10.6084/m9.figshare.22548267
title: Interactions between Special Education and Regular Education: pedagogical actions for blind students

description: Abstract: Pedagogical actions are analyzed that were carried out in the teaching of Mathematics to blind students, based on the interaction between Special Education and Regular Education. This is a qualitative study, of the descriptive-exploratory type, with a documental character. Based on Historical-Cultural Theory, it was carried out in a Specialized Educational Assistance Center dedicated to visual impairment. Entries in specific forms and dialogues written and recorded in audios, collected among the participating subjects, were used for data collection. The results show: (a) the interactions carried out between Special Education and Regular Education expand the teaching and learning of Mathematics to visually impaired students, as they articulate and complement the work between both; (b) interaction and study among teachers allow learning and conceptual changes about disability and the possibility of learning for these people, expanding research and studies on inclusive education.
DOI: 10.6084/m9.figshare.22548269.v1
title: Morphological and phenological variability of Guaraní maize germplasm from Northeastern Argentina (NEA)

description: Abstract Morphological and phenological variability of Guaraní maize germplasm from Northeastern Argentina (NEA) are potential sources of genetic resources, constituting valuable repositories of alleles associated with tolerance and resistance to biotic and abiotic stresses. Here, we studied the morphological and phenological variability in maize populations of 14 Guaraní landraces from NEA and analysed the relationship among them. These landraces were characterised according to the endosperm consistency of grain as Popcorn (Pc), Floury (F) and Floury with corneal periphery (F-Pc). There were inter-population differences in phenological characters as time from germination to tassel emergence, from germination to spike emergence and from germination to anthesis (length of vegetative cycle -LVC). The morphological and phenological data here reported were used to carry out a cluster analysis, in which the F and Pc populations appeared as two separate groups and the F-Pc populations were included in the F group. Thus, the well-defined F (including F-Pc) and Pc genetic pools should be prioritised within the framework of breeding plans as well as ex situ and in situ conservation programs. For these purposes it is essential the morphological, phenological and genetic characterisation the maize Guaraní landraces.
DOI: 10.6084/m9.figshare.22548272.v1
title: Feasibility of Left Ventricle Lead Implantation in Cardiac Resynchronization Therapy Guided by Gated SPECT and Ventricular Remodeling

description: Abstract Background Cardiac resynchronization therapy (CRT) may benefit patients with advanced heart failure (HF). Abnormal eccentricity index by gated SPECT is related to structural and functional alterations of the left ventricle (LV). Objective The aim of this study is to evaluate the feasibility of LV lead implantation guided by phase analysis and its relationship to ventricular remodeling. Methods Eighteen patients with indication for CRT underwent myocardial scintigraphy for implant orientation, and eccentricity and ventricular shape parameters were evaluated. P &lt; 0.05 was adopted as statistical significance. Results At baseline, most patients were classified as NYHA 3 (n = 12). After CRT, 11 out of 18 patients were reclassified to a lower degree of functional limitation. In addition, patients’ quality of life was improved post-CRT. Significant reductions were observed in QRS duration, PR interval, end-diastolic shape index, end-systolic shape index, stroke volume, and myocardial mass post-CRT. The CRT LV lead was positioned concordant, adjacent, and discordant in 11 (61.1%), 5 (27.8%), and 2 (11.1%) patients, respectively. End-systolic and end-diastolic eccentricity demonstrated reverse remodeling post-CRT. Conclusions LV lead implantation in CRT guided by gated SPECT scintigraphy is feasible. The placement of the electrode concordant or adjacent to the last segment to contract was a determinant of reverse remodeling.