cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8223020
title: Additional file 6: of Application of high-throughput amplicon sequencing-based SSR genotyping in genetic background screening

description: Table S5 Valid and comparable SSRs in DXT and DXB. The valid SSR loci in each sample are those SSR loci covered by at least 10 reads and with stutter ratios lower than 0.5. Comparable SSRs between two samples are those SSR loci that are valid in both samples. The genotype is the major genotype of the SSR locus, represented as the repeat unit with the repeat number, e.g., CGC4. The coverage represents the number of reads that support the genotype. The stutter ratio represents the ratio of the read numbers of the minor and major genotypes. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.8223020.v1
title: Additional file 6: of Application of high-throughput amplicon sequencing-based SSR genotyping in genetic background screening

description: Table S5 Valid and comparable SSRs in DXT and DXB. The valid SSR loci in each sample are those SSR loci covered by at least 10 reads and with stutter ratios lower than 0.5. Comparable SSRs between two samples are those SSR loci that are valid in both samples. The genotype is the major genotype of the SSR locus, represented as the repeat unit with the repeat number, e.g., CGC4. The coverage represents the number of reads that support the genotype. The stutter ratio represents the ratio of the read numbers of the minor and major genotypes. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.8223023
title: Additional file 13: of Ruminal microbiome-host crosstalk stimulates the development of the ruminal epithelium in a lamb model

description: Table S11. GO enrichment analysis of differentially expressed genes in biological processes. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.8223023.v1
title: Additional file 13: of Ruminal microbiome-host crosstalk stimulates the development of the ruminal epithelium in a lamb model

description: Table S11. GO enrichment analysis of differentially expressed genes in biological processes. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.8223026
title: Additional file 7: of Application of high-throughput amplicon sequencing-based SSR genotyping in genetic background screening

description: Table S6 Valid and comparable SSRs in DXT and Xa21m. The valid SSR loci in each sample are those SSR loci covered by at least 10 reads and with stutter ratios lower than 0.5. The comparable SSRs between two samples are those SSR loci that are valid in both samples. The genotype is the major genotype of the SSR locus, represented as the repeat unit with the repeat number, e.g., CGC4. The coverage represents the number of reads that support the genotype. The stutter ratio represents the ratio of the read numbers of the minor and major genotypes. Asterisks represent the differential SSRs between two samples, and &gt; 5 indicates that the length difference of differential SSRs between two samples is &gt; 5 bp. SSRs with length differences less than 5 bp were hardly distinguished by electrophoresis. The name in the national standard represents the name of the differential SSR in the National Agricultural Standard of China No. NY/T 1433–3014. (XLSX 36 kb)
DOI: 10.6084/m9.figshare.8223026.v1
title: Additional file 7: of Application of high-throughput amplicon sequencing-based SSR genotyping in genetic background screening

description: Table S6 Valid and comparable SSRs in DXT and Xa21m. The valid SSR loci in each sample are those SSR loci covered by at least 10 reads and with stutter ratios lower than 0.5. The comparable SSRs between two samples are those SSR loci that are valid in both samples. The genotype is the major genotype of the SSR locus, represented as the repeat unit with the repeat number, e.g., CGC4. The coverage represents the number of reads that support the genotype. The stutter ratio represents the ratio of the read numbers of the minor and major genotypes. Asterisks represent the differential SSRs between two samples, and &gt; 5 indicates that the length difference of differential SSRs between two samples is &gt; 5 bp. SSRs with length differences less than 5 bp were hardly distinguished by electrophoresis. The name in the national standard represents the name of the differential SSR in the National Agricultural Standard of China No. NY/T 1433–3014. (XLSX 36 kb)
DOI: 10.6084/m9.figshare.7698755
title: Additional file 1: of SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer

description: Table S1. Primers for real-time PCR and oligos for siRNAs or shRNAs. (XLSX 11â kb)
DOI: 10.6084/m9.figshare.7698755.v1
title: Additional file 1: of SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer

description: Table S1. Primers for real-time PCR and oligos for siRNAs or shRNAs. (XLSX 11â kb)
DOI: 10.6084/m9.figshare.16611669.v1
title: Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells

description: Numerous differentially expressed circular RNAs (circRNAs) have been identified; however, their roles have not been fully elucidated. Since dysregulated circRNAs may have clinical applications, it is vital to study their expression characteristics, function, and mechanism in prostate cancer cells. The role, regulatory mechanism, and expression of hsa_circ_0075542 were analyzed using quantitative reverse transcription polymerase chain reaction. The results indicated that the expression of hsa_circ_0075542 was downregulated in prostate tumor tissues. The functions of prostate cancer cell lines LNCaP and PC3 cells were assessed using cell counting kit-8 and transwell assays and flow cytometry analysis. The results of the functional experiments showed that overexpression of hsa_circ_0075542 suppressed cell proliferation, reduced migration and invasiveness capabilities, and promoted apoptosis. Moreover, hsa_circ_0075542 targeted the microRNA-1197 (miR-1197) homeobox C11 (HOXC11) axis by sponging miR-1197. Overexpression of miR-1197 played a tumor-promoting role. Overexpression of hsa_circ_0075542 alleviated the tumor-promoting effect of miR-1197 overexpression In conclusion, hsa_circ_0075542 suppressed malignant characteristics and promoted apoptosis in LNCaP and PC3 cells by acting as a competing endogenous RNA of miR-1197. The hsa_circ_0075542/miR-1197 axis might play a role via HOXC11.
DOI: 10.6084/m9.figshare.16611675
title: Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer

description: GDP dissociation inhibitor (<i>GDI)</i> regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting GDP dissociation. This study evaluated the potential prognostic and predictive value of <i>GDI1</i> in colorectal cancer (CRC). To address the prognostic power of <i>GDI1</i>, we performed individual and pooled survival analyses on six independent CRC microarray gene expression datasets. <i>GDI1</i>-enriched signatures were also analyzed. Kaplan–Meier and Cox proportional analyses were employed for survival analysis. An immunohistochemistry (IHC) analysis was performed to validate the clinical relevance and prognostic significance of the GDI1 protein level in CRC tissue samples. The results revealed that <i>GDI1</i> mRNA level was significantly linked with the aggressiveness of CRC, which is compatible with gene set enrichment analysis. A meta-analysis and pooled analysis demonstrated that a higher mRNA <i>GDI1</i> expression was dramatically correlated with a worse survival in a dose-dependent manner in CRC patients. Further IHC analysis validated that the protein expression of GDI1 in both cytoplasm and membrane also significantly impacted the outcome of CRC patients. In CRC patients with stage III, chemotherapy significantly reduced the relative risk of death in low-<i>GDI1</i> subgroup (hazard ratio (HR) = 0.22; 95% confidence interval (95% CI) 0.09–0.56, <i>p</i> = 0.0003), but not in high-<i>GDI1</i> subgroup (HR = 0.63; 95% CI 0.35–1.14, <i>p</i> = 0.1137). Therefore, both high mRNA and protein levels of GDI1 were significantly related to poor outcomes in CRC patients. <i>GD11</i> may serve as a prognostic biomarker for CRC.
DOI: 10.6084/m9.figshare.7698791
title: Additional file 8: of SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer

description: Table S5. Differential mRNA expression in SPAG5 overexpression MDA-MB-231 cells compared with that in vector cells in RNA-sequencing analysis. (XLSX 6260â kb)
DOI: 10.6084/m9.figshare.16611675.v2
title: Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer

description: GDP dissociation inhibitor (<i>GDI)</i> regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting GDP dissociation. This study evaluated the potential prognostic and predictive value of <i>GDI1</i> in colorectal cancer (CRC). To address the prognostic power of <i>GDI1</i>, we performed individual and pooled survival analyses on six independent CRC microarray gene expression datasets. <i>GDI1</i>-enriched signatures were also analyzed. Kaplan–Meier and Cox proportional analyses were employed for survival analysis. An immunohistochemistry (IHC) analysis was performed to validate the clinical relevance and prognostic significance of the GDI1 protein level in CRC tissue samples. The results revealed that <i>GDI1</i> mRNA level was significantly linked with the aggressiveness of CRC, which is compatible with gene set enrichment analysis. A meta-analysis and pooled analysis demonstrated that a higher mRNA <i>GDI1</i> expression was dramatically correlated with a worse survival in a dose-dependent manner in CRC patients. Further IHC analysis validated that the protein expression of GDI1 in both cytoplasm and membrane also significantly impacted the outcome of CRC patients. In CRC patients with stage III, chemotherapy significantly reduced the relative risk of death in low-<i>GDI1</i> subgroup (hazard ratio (HR) = 0.22; 95% confidence interval (95% CI) 0.09–0.56, <i>p</i> = 0.0003), but not in high-<i>GDI1</i> subgroup (HR = 0.63; 95% CI 0.35–1.14, <i>p</i> = 0.1137). Therefore, both high mRNA and protein levels of GDI1 were significantly related to poor outcomes in CRC patients. <i>GD11</i> may serve as a prognostic biomarker for CRC.
DOI: 10.6084/m9.figshare.7698791.v1
title: Additional file 8: of SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer

description: Table S5. Differential mRNA expression in SPAG5 overexpression MDA-MB-231 cells compared with that in vector cells in RNA-sequencing analysis. (XLSX 6260â kb)
DOI: 10.6084/m9.figshare.16611675.v1
title: Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer

description: GDP dissociation inhibitor (<i>GDI)</i> regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting GDP dissociation. This study evaluated the potential prognostic and predictive value of <i>GDI1</i> in colorectal cancer (CRC). To address the prognostic power of <i>GDI1</i>, we performed individual and pooled survival analyses on six independent CRC microarray gene expression datasets. <i>GDI1</i>-enriched signatures were also analyzed. Kaplan–Meier and Cox proportional analyses were employed for survival analysis. An immunohistochemistry (IHC) analysis was performed to validate the clinical relevance and prognostic significance of the GDI1 protein level in CRC tissue samples. The results revealed that <i>GDI1</i> mRNA level was significantly linked with the aggressiveness of CRC, which is compatible with gene set enrichment analysis. A meta-analysis and pooled analysis demonstrated that a higher mRNA <i>GDI1</i> expression was dramatically correlated with a worse survival in a dose-dependent manner in CRC patients. Further IHC analysis validated that the protein expression of GDI1 in both cytoplasm and membrane also significantly impacted the outcome of CRC patients. In CRC patients with stage III, chemotherapy significantly reduced the relative risk of death in low-<i>GDI1</i> subgroup (hazard ratio (HR) = 0.22; 95% confidence interval (95% CI) 0.09–0.56, <i>p</i> = 0.0003), but not in high-<i>GDI1</i> subgroup (HR = 0.63; 95% CI 0.35–1.14, <i>p</i> = 0.1137). Therefore, both high mRNA and protein levels of GDI1 were significantly related to poor outcomes in CRC patients. <i>GD11</i> may serve as a prognostic biomarker for CRC.
DOI: 10.5281/zenodo.10679502
title: 3D models of Glass-making processes v2

description: 3D models about the process of glass making
DOI: 10.5281/zenodo.10679503
title: 3D models of Glass-making processes v2

description: 3D models about the process of glass making
DOI: 10.6084/m9.figshare.16611778
title: Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis

description: Increasing evidence has indicated the implications of circular RNAs (circRNAs) in the development of colorectal cancer (CRC). In this study, we investigated the functional role and mechanism of circ_0089153 in CRC pathogenesis. The expression levels of circ_0089153, microRNA (miR)-198, and SUMO-specific peptidase 1 (SENP1) were gauged by quantitative real-time PCR (qRT-PCR) or western blot. Cell proliferation, sphere formation, tube formation, and apoptosis abilities were detected by 5-Ethynyl-2ʹ-Deoxyuridine (EdU), sphere formation, tube formation, and flow cytometry assays, respectively. The direct relationship between miR-198 and circ_0089153 or SENP1 was verified by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. The mouse xenograft assays were performed to evaluate the role of circ_0089153 <i>in vivo</i>. Our data showed that circ_0089153 was overexpressed in CRC tissues and cells. Depletion of circ_0089153 repressed cell proliferation, sphere formation ability, and enhanced cell apoptosis, as well as inhibited tube formation <i>in vitro</i>. Moreover, circ_0089153 depletion diminished tumor growth <i>in vivo</i>. Mechanistically, circ_0089153 targeted miR-198, and the effects of circ_0089153 were mediated by miR-198. SENP1 was identified as a direct and functional target of miR-198. Circ_0089153 worked as a competing endogenous RNA (ceRNA) to post-transcriptionally regulate SENP1 expression by miR-198. Our findings identify circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC.
DOI: 10.6084/m9.figshare.16611778.v2
title: Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis

description: Increasing evidence has indicated the implications of circular RNAs (circRNAs) in the development of colorectal cancer (CRC). In this study, we investigated the functional role and mechanism of circ_0089153 in CRC pathogenesis. The expression levels of circ_0089153, microRNA (miR)-198, and SUMO-specific peptidase 1 (SENP1) were gauged by quantitative real-time PCR (qRT-PCR) or western blot. Cell proliferation, sphere formation, tube formation, and apoptosis abilities were detected by 5-Ethynyl-2ʹ-Deoxyuridine (EdU), sphere formation, tube formation, and flow cytometry assays, respectively. The direct relationship between miR-198 and circ_0089153 or SENP1 was verified by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. The mouse xenograft assays were performed to evaluate the role of circ_0089153 <i>in vivo</i>. Our data showed that circ_0089153 was overexpressed in CRC tissues and cells. Depletion of circ_0089153 repressed cell proliferation, sphere formation ability, and enhanced cell apoptosis, as well as inhibited tube formation <i>in vitro</i>. Moreover, circ_0089153 depletion diminished tumor growth <i>in vivo</i>. Mechanistically, circ_0089153 targeted miR-198, and the effects of circ_0089153 were mediated by miR-198. SENP1 was identified as a direct and functional target of miR-198. Circ_0089153 worked as a competing endogenous RNA (ceRNA) to post-transcriptionally regulate SENP1 expression by miR-198. Our findings identify circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC.
DOI: 10.6084/m9.figshare.16611778.v1
title: Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis

description: Increasing evidence has indicated the implications of circular RNAs (circRNAs) in the development of colorectal cancer (CRC). In this study, we investigated the functional role and mechanism of circ_0089153 in CRC pathogenesis. The expression levels of circ_0089153, microRNA (miR)-198, and SUMO-specific peptidase 1 (SENP1) were gauged by quantitative real-time PCR (qRT-PCR) or western blot. Cell proliferation, sphere formation, tube formation, and apoptosis abilities were detected by 5-Ethynyl-2ʹ-Deoxyuridine (EdU), sphere formation, tube formation, and flow cytometry assays, respectively. The direct relationship between miR-198 and circ_0089153 or SENP1 was verified by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. The mouse xenograft assays were performed to evaluate the role of circ_0089153 <i>in vivo</i>. Our data showed that circ_0089153 was overexpressed in CRC tissues and cells. Depletion of circ_0089153 repressed cell proliferation, sphere formation ability, and enhanced cell apoptosis, as well as inhibited tube formation <i>in vitro</i>. Moreover, circ_0089153 depletion diminished tumor growth <i>in vivo</i>. Mechanistically, circ_0089153 targeted miR-198, and the effects of circ_0089153 were mediated by miR-198. SENP1 was identified as a direct and functional target of miR-198. Circ_0089153 worked as a competing endogenous RNA (ceRNA) to post-transcriptionally regulate SENP1 expression by miR-198. Our findings identify circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC.
DOI: 10.6084/m9.figshare.9796067
title: Effect of Aerodynamic Configuration Parameters on Lateral-Directional Stability of Double-Swept Flying Wing Aircraft

description: ABSTRACT: Poor lateral-directional stability due to the absence of vertical stabilizer is a great risk to the aircraft with flying wing layout. In this paper, an unmanned aerial vehicle with this kind of configuration is chosen as the research object. A three-dimensional model of the unmanned aerial vehicle is established, and then the sensitivity analysis is performed to obtain the effects of main aerodynamic shape parameters on lateral-directional flying quality. The results show that the roll mode and spiral mode of the aircraft meet the requirements of Level 1 flying quality in MIL-F-8785C. But the Dutch roll mode is generally divergent, which means that the flying quality of the aircraft is unacceptable. Thus it can be seen that the Dutch roll mode is the key to the dynamic stability of the aircraft. Further studies show that increasing the value of wing aspect ratio or decreasing the values of dihedral angle and torsion angle are useful for improving the Dutch roll mode. It is valuable to reveal the influence mechanism of aerodynamic shape parameters on lateral-directional flying quality for the design of flying wing aircraft.
DOI: 10.6084/m9.figshare.7698947
title: Additional file 2: of Developmental characteristics of pearl oyster Pinctada fucata martensii: insight into key molecular events related to shell formation, settlement and metamorphosis

description: Gene Ontology enrichment of differentially expressed genes in P. f. martensii (XLSX 22 kb)
DOI: 10.6084/m9.figshare.7698947.v1
title: Additional file 2: of Developmental characteristics of pearl oyster Pinctada fucata martensii: insight into key molecular events related to shell formation, settlement and metamorphosis

description: Gene Ontology enrichment of differentially expressed genes in P. f. martensii (XLSX 22 kb)
DOI: 10.6084/m9.figshare.20281863
title: Nickel isotopic compositions of mineral separates in Beiyan peridotites, Nickel isotopic compositions, FeO contents and Fe3+/∑Fe of nephelinites from eastern China

description: Nickel isotopic compositions of mineral separates in Beiyan peridotites determined by MC-ICP-MS.
Nickel isotpoic compositions of nephelinites from eastern China determined by MC-ICP-MS;  FeO of nephelinites was determined by redox titration using ammonium metavanadate to quantify the Fe<sup>3+</sup>/ΣFe.
DOI: 10.6084/m9.figshare.7698938
title: Additional file 1: of Developmental characteristics of pearl oyster Pinctada fucata martensii: insight into key molecular events related to shell formation, settlement and metamorphosis

description: Kegg enrichment of differentially expressed genes in P. f. martensii (XLSX 19 kb)
DOI: 10.6084/m9.figshare.7698938.v1
title: Additional file 1: of Developmental characteristics of pearl oyster Pinctada fucata martensii: insight into key molecular events related to shell formation, settlement and metamorphosis

description: Kegg enrichment of differentially expressed genes in P. f. martensii (XLSX 19 kb)
DOI: 10.6084/m9.figshare.9796124
title: Evaluation of three superior oblique surgical weakening procedures for A-pattern strabismus

description: ABSTRACT Purpose: To evaluate three superior oblique surgical weakening procedures for correcting A-pattern strabismus: tenectomy, superior oblique hang-back recession, and that involving the use of superior oblique suture spacers. Methods: The inclusion criteria were A-pattern strabismus ≥10Δ and horizontal deviation ≥10Δ, with no other ocular abnormality and a follow-up period of ≥6 months. The 24 patients (mean age, 16.3 ± 8.1 years; mean postoperative follow-up, 9.63 ± 3.11 months) were randomly divided into three groups of 8 patients each. Sigmascan® Pro 5.0 software was used to measure the degree of torsion pre- and postoperatively. Results: Preoperatively, the mean angles of A-pattern deviation were 19.33Δ° ± 3.53Δ° (tenectomy group), 15.71Δ° ± 1.11Δ° (hang-back recession group), and 14.62Δ° ± 1.18Δ° (suture spacers group); these values did not differ significantly. At the final follow-up examination, the mean angles of A-pattern deviation were 4.67Δ° ± 0.67Δ° (tenectomy group), 6.29Δ° ± 1.48Δ° (hang-back recession group), and 4.38Δ° ± 1.03Δ° (suture spacers group), with no statistically significant difference in the correction in A-pattern strabismus among the three groups. Preoperatively, the mean torsional angles were +5.4° ± 3.9° (tenectomy group), +5.6° ± 4.9° (hang-back recession group), and +6.0° ± 3.3° (suture spacers group); these values did not differ significantly. At the final follow-up examination, the mean torsional angles were + 0.3° ± 5.6° (tenectomy group), +0.5° ± 4.6° (hang-back recession group), and +0.2° ± 5.2° (suture spacers group), with no statistically significant difference in the intorsion correction among the three groups. Conclusion: All three superior oblique weakening procedures were effective for correcting A-pattern strabismus and fundus intorsion.