cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60645/bdc-4g68-sjso
title: Population Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Atherosclerosis Risk in Communities (ARIC)

description: 
This sub-study [phs000223](study.cgi?study_id=phs000223) PAGE CALiCo ARIC contains genotype data and selected phenotype of subjects available from the [phs000223](study.cgi?study_id=phs000223). Summary level phenotypes for the NHLBI ARIC Cohort study participants can be viewed at the top-level study page [phs000280](study.cgi?study_id=phs000280) ARIC Cohort. Individual level phenotype data and molecular data for all ARIC Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI ARIC Cohort [phs000280](study.cgi?study_id=phs000280) study.

**CALiCo ARIC**<br> The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date. ARIC includes a Cohort Component and a Community Surveillance Component. Cohort enrollment began in 1987. Each ARIC field center randomly selected and recruited a sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive examination, including medical, social, and demographic data. These participants were reexamined every three years with the first screen (baseline) occurring in 1987-89, the second in 1990-92, the third in 1993-95, and the fourth and last exam wastook place in 1996-98. Follow-up occurs yearly byA fifth cohort examination is underway (2011-2013). Yearly telephone tointerviews maintain contact with participants and to assess health status of the cohort.

In the Community Surveillance Component, currently ongoing, these four communities are investigated to determine the community-wide occurrence of hospitalized myocardial infarction and coronary heart disease deaths in men and women aged 35-84 years. Hospitalized stroke is investigated in cohort participants only. The study conducts community surveillance of inpatient heart failure (ages 55 years and older) and cohort surveillance outpatient heart failure events beginning in 2005.

This study is part of the Population Architecture using Genomics and Epidemiology (PAGE) study [phs000356](study.cgi?study_id=phs000356).
DOI: 10.60645/bdc-3f95-58z1
title: STAMPEED: Cardiovascular Health Study (CHS)

description: 
** Note: This substudy phs000226 STAMPEED Cardiovascular Health Study contains GWAS data of the subset of the CHS cohort selected for the NHLBI&#39;s SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) project. Summary level phenotypes for the Cardiovascular Health Study Cohort study participants can be viewed at the top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort. Individual level phenotype data and molecular data for the Cardiovascular Health Study top-level study and substudies are available by requesting Authorized Access to the Cardiovascular Health Study (CHS) Cohort study [phs000287](./study.cgi?study_id=phs000287). **

The primary aim of the study is to conduct a genome-wide association study to identify genetic variants associated with the incidence of myocardial infarction (MI), stroke, and heart failure (HF) among participants enrolled in the Cardiovascular Health Study (CHS) who were free of clinical cardiovascular disease at baseline. The secondary aim is to conduct genome-wide association study of other phenotypes in CHS. The study is an ancillary study to CHS. CHS is a population-based cohort study of risk factors for heart disease and stroke among older adults recruited at 4 US sites in 1989-1990. Subjects underwent an extensive baseline examination, and annual follow-up examinations through 1988-1999.
DOI: 10.60645/bdc-15zm-0s4w
title: STAMPEED: Cardiovascular Health Study (CHS)

description: 
** Note: This substudy phs000226 STAMPEED Cardiovascular Health Study contains GWAS data of the subset of the CHS cohort selected for the NHLBI&#39;s SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) project. Summary level phenotypes for the Cardiovascular Health Study Cohort study participants can be viewed at the top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort. Individual level phenotype data and molecular data for the Cardiovascular Health Study top-level study and substudies are available by requesting Authorized Access to the Cardiovascular Health Study (CHS) Cohort study [phs000287](./study.cgi?study_id=phs000287). **

The primary aim of the study is to conduct a genome-wide association study to identify genetic variants associated with the incidence of myocardial infarction (MI), stroke, and heart failure (HF) among participants enrolled in the Cardiovascular Health Study (CHS) who were free of clinical cardiovascular disease at baseline. The secondary aim is to conduct genome-wide association study of other phenotypes in CHS. The study is an ancillary study to CHS. CHS is a population-based cohort study of risk factors for heart disease and stroke among older adults recruited at 4 US sites in 1989-1990. Subjects underwent an extensive baseline examination, and annual follow-up examinations through 1988-1999.
DOI: 10.60645/bdc-9369-1g59
title: STAMPEED: Cardiovascular Health Study (CHS)

description: 
** Note: This substudy phs000226 STAMPEED Cardiovascular Health Study contains GWAS data of the subset of the CHS cohort selected for the NHLBI&#39;s SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) project. Summary level phenotypes for the Cardiovascular Health Study Cohort study participants can be viewed at the top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort. Individual level phenotype data and molecular data for the Cardiovascular Health Study top-level study and substudies are available by requesting Authorized Access to the Cardiovascular Health Study (CHS) Cohort study [phs000287](./study.cgi?study_id=phs000287). **

The primary aim of the study is to conduct a genome-wide association study to identify genetic variants associated with the incidence of myocardial infarction (MI), stroke, and heart failure (HF) among participants enrolled in the Cardiovascular Health Study (CHS) who were free of clinical cardiovascular disease at baseline. The secondary aim is to conduct genome-wide association study of other phenotypes in CHS. The study is an ancillary study to CHS. CHS is a population-based cohort study of risk factors for heart disease and stroke among older adults recruited at 4 US sites in 1989-1990. Subjects underwent an extensive baseline examination, and annual follow-up examinations through 1988-1999.
DOI: 10.5284/1139168
title: Digital Archive from Level 2/3 Descriptive and Analytical Historic Building Recording and Archaeological Excavation at Shire Hill Hospital, Glossop, Derbyshire, September 2023 - December 2024

description: This collection comprises images and site records from a Level 2/3 Descriptive and Analytical Historic Building Recording and Archaeological Excavation at Shire Hill Hospital, Glossop, Derbyshire. The work was carried out by Archaeological Services WYAS from September 2023 to December 2024. Shire Hill Hospital comprises the former Glossop Union Workhouse built in 1832-1834 with later-C19 and early-C20 extensions, and Infirmary built in 1896-1897 with C20 extensions. The building recording focused on the most historic structures on the site including parts of the original workhouse, workhouse infirmary and a small cottage building. The excavation work followed a previous trial trench evaluation and involved the investigation of three areas of the site where former workhouse buildings once stood. The project produced evidence for the development of the site from extant historic structures and excavations of the remains of demolished early buildings of the workhouse.
DOI: 10.60645/bdc-879x-se00
title: STAMPEED: Cardiovascular Health Study (CHS)

description: 
** Note: This substudy phs000226 STAMPEED Cardiovascular Health Study contains GWAS data of the subset of the CHS cohort selected for the NHLBI&#39;s SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) project. Summary level phenotypes for the Cardiovascular Health Study Cohort study participants can be viewed at the top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort. Individual level phenotype data and molecular data for the Cardiovascular Health Study top-level study and substudies are available by requesting Authorized Access to the Cardiovascular Health Study (CHS) Cohort study [phs000287](./study.cgi?study_id=phs000287). **

The primary aim of the study is to conduct a genome-wide association study to identify genetic variants associated with the incidence of myocardial infarction (MI), stroke, and heart failure (HF) among participants enrolled in the Cardiovascular Health Study (CHS) who were free of clinical cardiovascular disease at baseline. The secondary aim is to conduct genome-wide association study of other phenotypes in CHS. The study is an ancillary study to CHS. CHS is a population-based cohort study of risk factors for heart disease and stroke among older adults recruited at 4 US sites in 1989-1990. Subjects underwent an extensive baseline examination, and annual follow-up examinations through 1988-1999.
DOI: 10.60645/bdc-5413-8z32
title: PAGE: CALiCo: Coronary Artery Risk Development in Young Adults(CARDIA)

description: 
This sub-study [phs000236](./study.cgi?study_id=phs000236) PAGE CALiCo CARDIA contains genotype derived from sequence data and selected phenotype of subjects available from the [phs000236](./study.cgi?study_id=phs000236) study. Summary level phenotypes for the NHLBI CARDIA Cohort study participants can be viewed at the top-level study page [phs000285](./study.cgi?study_id=phs000285) CARDIA Cohort. Individual level phenotype data and molecular data for all CARDIA Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI CARDIA Cohort [phs000285](./study.cgi?study_id=phs000285) study.

**CALiCo CARDIA**<br/> The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining how heart disease develops in adults. It began in 1986 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be approximately the same number of people in subgroups of race, gender, education (high school or less and more than high school) and age (18-24 and 25-30) in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), and 2005-2006 (Year 20). A majority of the group has been examined at each of the follow-up examinations (90%, 86%, 81%, 79%, 74%, and 72%, respectively).

While the specifics of each examination has differed somewhat, data have been collected on a variety of factors believed to be related to heart disease. These include conditions with clear links to heart disease such as blood pressure, cholesterol and other lipids. Data have also been collected on physical measurements such as weight and skinfold fat as well as lifestyle factors such as substance use (tobacco and alcohol), dietary and exercise patterns, behavioral and psychological variables, medical and family history, and other chemistries (e.g., insulin and glucose). In addition, subclinical atherosclerosis was measured via echocardiography during Years 5 and 10, computed tomography during Years 15 and 20, and carotid ultrasound during Year 20. A detailed description of the study and results from the first examination are summarized in Cutter et al (Controlled Clinical Trials, Volume 12, Number 1 [supplement], pages 1S-77S, 1991).

This study is part of the Population Architecture using Genomics and Epidemiology (PAGE) study [phs000356](./study.cgi?study_id=phs000356).
DOI: 10.60645/bdc-e434-b10m
title: PAGE: CALiCo: Coronary Artery Risk Development in Young Adults(CARDIA)

description: 
This sub-study [phs000236](./study.cgi?study_id=phs000236) PAGE CALiCo CARDIA contains genotype derived from sequence data and selected phenotype of subjects available from the [phs000236](./study.cgi?study_id=phs000236) study. Summary level phenotypes for the NHLBI CARDIA Cohort study participants can be viewed at the top-level study page [phs000285](./study.cgi?study_id=phs000285) CARDIA Cohort. Individual level phenotype data and molecular data for all CARDIA Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI CARDIA Cohort [phs000285](./study.cgi?study_id=phs000285) study.

**CALiCo CARDIA**<br/> The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining how heart disease develops in adults. It began in 1986 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be approximately the same number of people in subgroups of race, gender, education (high school or less and more than high school) and age (18-24 and 25-30) in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), and 2005-2006 (Year 20). A majority of the group has been examined at each of the follow-up examinations (90%, 86%, 81%, 79%, 74%, and 72%, respectively).

While the specifics of each examination has differed somewhat, data have been collected on a variety of factors believed to be related to heart disease. These include conditions with clear links to heart disease such as blood pressure, cholesterol and other lipids. Data have also been collected on physical measurements such as weight and skinfold fat as well as lifestyle factors such as substance use (tobacco and alcohol), dietary and exercise patterns, behavioral and psychological variables, medical and family history, and other chemistries (e.g., insulin and glucose). In addition, subclinical atherosclerosis was measured via echocardiography during Years 5 and 10, computed tomography during Years 15 and 20, and carotid ultrasound during Year 20. A detailed description of the study and results from the first examination are summarized in Cutter et al (Controlled Clinical Trials, Volume 12, Number 1 [supplement], pages 1S-77S, 1991).

This study is part of the Population Architecture using Genomics and Epidemiology (PAGE) study [phs000356](./study.cgi?study_id=phs000356).
DOI: 10.60645/bdc-47o8-72h5
title: Genetic Analysis of Limb Malformation Disorders: Miller Syndrome Sequencing Study (LMD-MS)

description: 
The overall goal of this project is to investigate the etiology and pathogenesis of malformations (i.e., birth defects) of the  	limb, concentrating on abnormalities of limb patterning such as limb deficiency/duplications and multiple congenital contractures.

The exome sequences of two siblings and two unrelated individuals were obtained by massively parallel DNA sequencing.  	The four individuals were affected with Miller syndrome (OMIM: [263750](http://www.ncbi.nlm.nih.gov/omim/263750)).

Additionally, the whole-genome sequences of a family of four were obtained with the method of Complete Genomics Incorporated (CGI).  	The two offspring were both affected with Miller syndrome and is the same sibling pair mentioned previously from whom exome sequences  	were also obtained.
DOI: 10.60645/bdc-xc89-70h3
title: Human Liver Cohort (HLC)

description: 
The Human Liver Cohort (HLC) study aimed to characterize the genetic architecture of gene expression in human liver 

	using genotyping, gene expression profiling, and enzyme activity measurements of Cytochrom P450. The HLC was assembled 

	from a total of 780 liver samples screened.  DNA samples were genotyped on the Affymetrix 500K SNP and Illumina 650Y 

	SNP genotyping arrays.  Only data from those samples which were collected postmortem are accessible through this submission.  

	These 228 samples represent a subset of the 427 samples included in the Human Liver Cohort Publication (Schadt, Molony 

	et al. 2008, PMID: [18462017](http://www.ncbi.nlm.nih.gov/pubmed/18462017)).   

	RNA samples were profiled on a custom Agilent 44,000 feature microarray composed of 39,280 oligonucleotide probes targeting 

	transcripts representing 34,266 known and predicted genes, including high-confidence, noncoding RNA sequences. Gene Expression 

	data for the samples from which it could be obtained is available in GEO under accession number GSE9588.

Results and networks will be made available for download from Sage Bionetworks.
DOI: 10.60645/bdc-125n-155q
title: NHLBI GO-ESP: Early-Onset Myocardial Infarction (Broad EOMI)

description: 
The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with heart, lung and blood diseases. These and related diseases that are of high impact to public health and individuals from diverse racial and ethnic groups will be studied. These data may help researchers understand the causes of disease, contributing to better ways to prevent, diagnose, and treat diseases, as well as determine whether to tailor prevention and treatments to specific populations. This could lead to more effective treatments and reduce the likelihood of side effects. GO-ESP is comprised of five collaborative components: 3 cohort consortia - HeartGO, LungGO, and WHISP - and 2 sequencing centers - BroadGO and SeattleGO.

In the Grand Opportunities Exome Sequencing Program Early MI Project (GO ESP - EOMI), we are sequencing cases with extremely early-onset MI drawn from 8 cohorts. These cohorts include five hospital or community-based studies that ascertained individuals based on MI status. These include PennCATH, Cleveland Clinic Genebank, Massachusetts General Hospital Premature Coronary Artery Disease Study (MGH-PCAD), Heart Attack Risk in Puget Sound (HARPS), and Translational Research Investigating Underlying Disparities in Myocardial Infarction Patients&#39; Health Status (TRIUMPH). Cases were selected based on MI occurring in men aged &#8804;50 years and women aged &#8804;60 years. In addition, early-MI cases are being drawn from three population-cohort studies including the Framingham Heart Study, the Women&#39;s Health Initiative, and the Atherosclerosis Risk in Communities Study. MI-free controls are being drawn from five population-based cohort studies including the Framingham Heart Study, the Women&#39;s Health Initiative, Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and the Jackson Heart Study. Controls were selected based on two factors: (1) highest predicted risk for MI based on Framingham risk score; and (2) absence of prevalent or incident MI despite a high predicted risk.
DOI: 10.60645/bdc-md62-7zyg
title: Atherosclerosis Risk in Communities (ARIC) Cohort

description: 
The Atherosclerosis Risk in Communities (ARIC) Study, sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. The four communities are Forsyth County, NC; Jackson, MS; the northwest suburbs of Minneapolis, MN; and Washington County, MD. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date.

ARIC includes two parts: the Cohort Component and the Community Surveillance Component. The Cohort Component began in 1987, and each ARIC field center randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive examination, including medical, social, and demographic data. These participants were examined with the baseline visit occurring in 1987-89, the second visit in 1990-92, the third visit in 1993-95, the fourth visit in 1996-98, the fifth visit in 2011-13, the sixth visit 2016-17 and the seventh visit 2018-19. Follow-up occurs yearly by telephone to maintain contact with participants and to assess health status of the cohort. 

In the Community Surveillance Component, these four communities were investigated to determine the community-wide occurrence of hospitalized myocardial infarction and coronary heart disease deaths in men and women aged 35-84 years. Hospitalized stroke is investigated in cohort participants only. Starting in 2006, the study conducted community surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) for heart failure events beginning in 2005. Community Surveillance for non-cohorts ended in event year 2014.

ARIC is currently funded through 2028.

**The ARIC Cohort is utilized in the following dbGaP sub-studies.** To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" section of this top-level study page [phs000280](study.cgi?study_id=phs000280) ARIC Cohort. 
 - [phs000557](study.cgi?study_id=phs000557) ARIC_CARe - [phs000090](study.cgi?study_id=phs000090) GENEVA_ARIC - [phs000223](study.cgi?study_id=phs000223) PAGE_CALiCo_ARIC - [phs000398](study.cgi?study_id=phs000398) GO-ESP: HeartGo_ARIC - [phs000668](study.cgi?study_id=phs000668) CHARGE_ARIC - [phs000860](study.cgi?study_id=phs000860) MICORTEX - [phs001536](study.cgi?study_id=phs001536) CCDG_ARIC