cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24707478
title: Role of the CD40–CD40L expression level pathway in the diagnosis of unexplained recurrent pregnancy loss

description: Unexplained recurrent spontaneous pregnancy loss (URPL) lacks effective treatment and reliable early diagnosis and prediction. Immunologic dysfunction can be an underlying cause of recurrent pregnancy loss (RPL). Considering the regulatory role of CD40–CD40L in immune responses, we explored its clinical significance in URPL. The 108 women with URPL who were treated in Hebei Yanda Hospital from January 2020 to December 2022 were selected as study subjects, and another 108 healthy women who were not pregnant and matched with the age and body mass index of the study group were selected as the control group. CD40 and CD4 + CD25 + Treg cells in peripheral blood mononuclear cells (PBMCs) and CD40L in peripheral blood platelets were measured by flow cytometry. The predictive value of CD40–CD40L in URPL for the risk of RPL was determined by receiver operating characteristic (ROC) curves. The correlations of CD40–CD40L with CD4 + CD25 + Treg cells and serum pro-inflammatory factors were assessed by Pearson’s analysis. CD40 on the surface of PBMCs and CD40L on the surface of platelets were up-regulated in URPL patients. CD40 in combination with CD40L had high predictive value for the risk of RPL in URPL patients. Peripheral blood CD40–CD40L was positively linked to IL-17 and IL-23, and negatively to CD4 + CD25 + Treg cells and IL-10 in URPL patients. The CD40–CD40L pathway expression in peripheral blood can help predict the risk of RPL in URPL patients. This study discovered significant increases in the blood levels of two transmembrane glycoproteins, CD40 and CD40L, in patients with two or more consecutive unexplained recurrent spontaneous pregnancy loss, compared to healthy women. The elevated levels of CD40 and CD40L indicated an increased risk of recurrent pregnancy loss in these patients, which could help early and timely management of these patients.
DOI: 10.6084/m9.figshare.24707478.v1
title: Role of the CD40–CD40L expression level pathway in the diagnosis of unexplained recurrent pregnancy loss

description: Unexplained recurrent spontaneous pregnancy loss (URPL) lacks effective treatment and reliable early diagnosis and prediction. Immunologic dysfunction can be an underlying cause of recurrent pregnancy loss (RPL). Considering the regulatory role of CD40–CD40L in immune responses, we explored its clinical significance in URPL. The 108 women with URPL who were treated in Hebei Yanda Hospital from January 2020 to December 2022 were selected as study subjects, and another 108 healthy women who were not pregnant and matched with the age and body mass index of the study group were selected as the control group. CD40 and CD4 + CD25 + Treg cells in peripheral blood mononuclear cells (PBMCs) and CD40L in peripheral blood platelets were measured by flow cytometry. The predictive value of CD40–CD40L in URPL for the risk of RPL was determined by receiver operating characteristic (ROC) curves. The correlations of CD40–CD40L with CD4 + CD25 + Treg cells and serum pro-inflammatory factors were assessed by Pearson’s analysis. CD40 on the surface of PBMCs and CD40L on the surface of platelets were up-regulated in URPL patients. CD40 in combination with CD40L had high predictive value for the risk of RPL in URPL patients. Peripheral blood CD40–CD40L was positively linked to IL-17 and IL-23, and negatively to CD4 + CD25 + Treg cells and IL-10 in URPL patients. The CD40–CD40L pathway expression in peripheral blood can help predict the risk of RPL in URPL patients. This study discovered significant increases in the blood levels of two transmembrane glycoproteins, CD40 and CD40L, in patients with two or more consecutive unexplained recurrent spontaneous pregnancy loss, compared to healthy women. The elevated levels of CD40 and CD40L indicated an increased risk of recurrent pregnancy loss in these patients, which could help early and timely management of these patients.
DOI: 10.6084/m9.figshare.24018173
title: KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1

description: Endometrial cancer (EC) is the most common gynaecologic malignancy. This study was to explore the role of kruppel-like factor 2 (KLF2) in EC cell behaviours. The expression of KLF2 in EC and its correlation with NPM1 were first predicted on the database. Levels of KLF2 and nucleophosmin 1 (NPM1) in EC cell lines were then determined. After transfection of the overexpression vector of KLF2 or NPM1, cell proliferation, invasion, and migration were evaluated. The binding relationship between KLF2 and the NPM1 promoter was analysed. KLF2 was downregulated while NPM1 was upregulated in EC cells. KLF2 overexpression reduced the proliferation potential of EC cells and the number of invaded and migrated cells. KLF2 was enriched in the NPM1 promoter and inhibited NPM1 transcriptional level. NPM1 overexpression neutralised the effects of KLF2 overexpression on suppressing EC cell growth. Collectively, KLF2 was decreased in EC cells and KLF2 overexpression increased the binding to the NPM1 promoter to inhibit NPM1 transcription, thus suppressing EC cell growth. <b>What is already known on this subject?</b> Endometrial cancer (EC) sees a significant increase in prevalence globally with poor survival rates. KLF2 has been recognised as a tumour suppressor in a variety of malignancies. NPM1 can regulate EC cell viability and apoptosis.<b>What do the results of this study add?</b> This study highlighted that KLF2 produces an anti-tumour effect in EC and KLF2 can regulate NPM1 expression in EC and thereafter affect the proliferative, migratory, and invasive abilities of EC cells.<b>What are the implications of these findings for clinical practice and/or further research?</b> KLF2 overexpression suppresses NPM1 transcription and inhibits EC cell growth. Targeting KLF2 overexpression may be useful for EC treatment in clinical practice. <b>What is already known on this subject?</b> Endometrial cancer (EC) sees a significant increase in prevalence globally with poor survival rates. KLF2 has been recognised as a tumour suppressor in a variety of malignancies. NPM1 can regulate EC cell viability and apoptosis. <b>What do the results of this study add?</b> This study highlighted that KLF2 produces an anti-tumour effect in EC and KLF2 can regulate NPM1 expression in EC and thereafter affect the proliferative, migratory, and invasive abilities of EC cells. <b>What are the implications of these findings for clinical practice and/or further research?</b> KLF2 overexpression suppresses NPM1 transcription and inhibits EC cell growth. Targeting KLF2 overexpression may be useful for EC treatment in clinical practice.
DOI: 10.6084/m9.figshare.24018173.v1
title: KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1

description: Endometrial cancer (EC) is the most common gynaecologic malignancy. This study was to explore the role of kruppel-like factor 2 (KLF2) in EC cell behaviours. The expression of KLF2 in EC and its correlation with NPM1 were first predicted on the database. Levels of KLF2 and nucleophosmin 1 (NPM1) in EC cell lines were then determined. After transfection of the overexpression vector of KLF2 or NPM1, cell proliferation, invasion, and migration were evaluated. The binding relationship between KLF2 and the NPM1 promoter was analysed. KLF2 was downregulated while NPM1 was upregulated in EC cells. KLF2 overexpression reduced the proliferation potential of EC cells and the number of invaded and migrated cells. KLF2 was enriched in the NPM1 promoter and inhibited NPM1 transcriptional level. NPM1 overexpression neutralised the effects of KLF2 overexpression on suppressing EC cell growth. Collectively, KLF2 was decreased in EC cells and KLF2 overexpression increased the binding to the NPM1 promoter to inhibit NPM1 transcription, thus suppressing EC cell growth. <b>What is already known on this subject?</b> Endometrial cancer (EC) sees a significant increase in prevalence globally with poor survival rates. KLF2 has been recognised as a tumour suppressor in a variety of malignancies. NPM1 can regulate EC cell viability and apoptosis.<b>What do the results of this study add?</b> This study highlighted that KLF2 produces an anti-tumour effect in EC and KLF2 can regulate NPM1 expression in EC and thereafter affect the proliferative, migratory, and invasive abilities of EC cells.<b>What are the implications of these findings for clinical practice and/or further research?</b> KLF2 overexpression suppresses NPM1 transcription and inhibits EC cell growth. Targeting KLF2 overexpression may be useful for EC treatment in clinical practice. <b>What is already known on this subject?</b> Endometrial cancer (EC) sees a significant increase in prevalence globally with poor survival rates. KLF2 has been recognised as a tumour suppressor in a variety of malignancies. NPM1 can regulate EC cell viability and apoptosis. <b>What do the results of this study add?</b> This study highlighted that KLF2 produces an anti-tumour effect in EC and KLF2 can regulate NPM1 expression in EC and thereafter affect the proliferative, migratory, and invasive abilities of EC cells. <b>What are the implications of these findings for clinical practice and/or further research?</b> KLF2 overexpression suppresses NPM1 transcription and inhibits EC cell growth. Targeting KLF2 overexpression may be useful for EC treatment in clinical practice.
DOI: 10.48420/24923067
title: Fructose dehydration data - Catalysts

description: Underpinning data set for Impact of Porous Silica Nanosphere Architectures on the Catalytic Performance of Supported Sulphonic Acid Sites for Fructose Dehydration to 5-HydroxymethylfurfuralC.-A. H. Price, A. Torres-Lopez, R. Evans, N. S. Hondow, M. A. Isaacs, A. S. Jamal, C. M. A. Parlett, <i>ChemPlusChem</i> 2023, 88, e202300413.https://doi.org/10.1002/cplu.202300413
DOI: 10.34740/kaggle/dsv/7330513
title: 2021 World Population (updated daily)
DOI: 10.6084/m9.figshare.24936300
title: Supplementary materials: What works when: mapping patient and stakeholder engagement methods along the ten-step continuum framework

description: <b>These are peer-reviewed supplementary table</b>s<b> for the article '</b><b>What works when: mapping patient and stakeholder engagement methods along the ten-step continuum framework</b><b>' published in the </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b>Supplemental Table A. CINAHL® (Cumulative Index of Nursing and Allied Health) Database Search StringSupplemental Table B. Patient Participant Counts for Game Board ResponsesSupplemental Table C. Researcher Participant Counts for Game Board ResponsesSupplemental Table D. Other Stakeholder Participant Counts for Game Board ResponsesSupplemental Table E. Qualitative Summary – Concepts by Participant Group<b>Summary: </b><b>Aim:</b> This study provides a recommended ‘patient engagement translation table’ that identifies evidence-based methods for meaningful patient engagement along a ten-step framework for continuous engagement. <b>Materials & methods:</b> We used a mixed methods research design to collect data on preferred engagement methods, including an environmental scan of available literature, interviews and focus groups with patient-centered outcomes research stakeholders to match methods with research steps and a modified Delphi process with subject matter experts to create the final translation table. <b>Results:</b> Evidence-based engagement methods included community partnerships, focus groups, interviews, meetings, sharing print materials, social media, storytelling, surveys and including patients as research team members. <b>Conclusion:</b> Our recommended patient engagement translation table is designed to assist investigators in determining appropriate engagement methods for meaningful interactions with stakeholders.
DOI: 10.6084/m9.figshare.24936300.v1
title: Supplementary materials: What works when: mapping patient and stakeholder engagement methods along the ten-step continuum framework

description: <b>These are peer-reviewed supplementary table</b>s<b> for the article '</b><b>What works when: mapping patient and stakeholder engagement methods along the ten-step continuum framework</b><b>' published in the </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b>Supplemental Table A. CINAHL® (Cumulative Index of Nursing and Allied Health) Database Search StringSupplemental Table B. Patient Participant Counts for Game Board ResponsesSupplemental Table C. Researcher Participant Counts for Game Board ResponsesSupplemental Table D. Other Stakeholder Participant Counts for Game Board ResponsesSupplemental Table E. Qualitative Summary – Concepts by Participant Group<b>Summary: </b><b>Aim:</b> This study provides a recommended ‘patient engagement translation table’ that identifies evidence-based methods for meaningful patient engagement along a ten-step framework for continuous engagement. <b>Materials & methods:</b> We used a mixed methods research design to collect data on preferred engagement methods, including an environmental scan of available literature, interviews and focus groups with patient-centered outcomes research stakeholders to match methods with research steps and a modified Delphi process with subject matter experts to create the final translation table. <b>Results:</b> Evidence-based engagement methods included community partnerships, focus groups, interviews, meetings, sharing print materials, social media, storytelling, surveys and including patients as research team members. <b>Conclusion:</b> Our recommended patient engagement translation table is designed to assist investigators in determining appropriate engagement methods for meaningful interactions with stakeholders.
DOI: 10.6084/m9.figshare.24936318
title: Source data and code for Fig. 1a and Fig. 2

description: This repository contains R code and data for our manuscript:"<b>Hidden zoonotic risk: immunogenetic-pathogen networks shrink in a generalist rodent inhabiting disturbed landscapes</b>"by Ramona Fleischer, Georg Joachim Eibner, Nina Isabell Schwensow, Sofia Paraskevopoulou, Gerd Mayer, Victor Max Corman, Christian Drosten, Kerstin Wilhelm, Alexander Christoph Heni, Simone Sommer and Dominik Werner SchmidIn this work we examined the effect of anthropogenic disturbance at the landscape level on neutral genetic diversity and diversity at the important immune gene region of the Major Histocompatibility Complex class II and multiple pathogen infections in a common neotropical rodent generalist, the Tomey's spiny rat (<i>Proechimys semispinosus</i>).This file contains one of the layers that are necessary to produce figure 2 of the main manuscript using the circos software.
DOI: 10.6084/m9.figshare.24936318.v1
title: Source data and code for Fig. 1a and Fig. 2

description: This repository contains R code and data for our manuscript:"<b>Hidden zoonotic risk: immunogenetic-pathogen networks shrink in a generalist rodent inhabiting disturbed landscapes</b>"by Ramona Fleischer, Georg Joachim Eibner, Nina Isabell Schwensow, Sofia Paraskevopoulou, Gerd Mayer, Victor Max Corman, Christian Drosten, Kerstin Wilhelm, Alexander Christoph Heni, Simone Sommer and Dominik Werner SchmidIn this work we examined the effect of anthropogenic disturbance at the landscape level on neutral genetic diversity and diversity at the important immune gene region of the Major Histocompatibility Complex class II and multiple pathogen infections in a common neotropical rodent generalist, the Tomey's spiny rat (<i>Proechimys semispinosus</i>).This file contains one of the layers that are necessary to produce figure 2 of the main manuscript using the circos software.
DOI: 10.34740/kaggle/dsv/7330548
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.5281/zenodo.10454258
title: Data underpinning "Temperature flow in pseudo-Majorana functional renormalization for quantum spins"

description: Data and plotting scripts.

The data is zipped as a .tar. To unzip and install all dependencies, please run `julia setupEnv.jl".

to generate plots, run `julia PlotAll.jl`
DOI: 10.5281/zenodo.10454259
title: Data underpinning "Temperature flow in pseudo-Majorana functional renormalization for quantum spins"

description: Data and plotting scripts.

The data is zipped as a .tar. To unzip and install all dependencies, please run `julia setupEnv.jl".

to generate plots, run `julia PlotAll.jl`
DOI: 10.5281/zenodo.10429096
title: A comparative analysis of somatic mutations occurring at "common" loci and other loci with the TCGA somatic mutation dataset.

description: A comparative analysis of somatic mutations occurring at "common" loci and other loci with the TCGA somatic mutation dataset.
DOI: 10.5281/zenodo.10453323
title: A comparative analysis of somatic mutations occurring at "common" loci and other loci with the TCGA somatic mutation dataset.

description: A comparative analysis of somatic mutations occurring at "common" loci and other loci with the TCGA somatic mutation dataset.
DOI: 10.5281/zenodo.10396426
title: test

description: test dataset

each json file is a list of dictionaries, where each dictionary contains a speech, the speech's speaker, date, filename of ga meeting and speaker's country where applicable
DOI: 10.5281/zenodo.10396427
title: test

description: test dataset

each json file is a list of dictionaries, where each dictionary contains a speech, the speech's speaker, date, filename of ga meeting and speaker's country where applicable
DOI: 10.5281/zenodo.10454310
title: test

description: test dataset

each json file is a list of dictionaries, where each dictionary contains a speech, the speech's speaker, date, filename of ga meeting and speaker's country where applicable
DOI: 10.5517/ccdc.csd.cc2dnq82
title: CCDC 2224444: Experimental Crystal Structure Determination

description: Related Article: Cong Guo, Hui-Jun Geng, Wen-Ji Wang, Yan-Xiang Liu, Lu Deng, Jun-Mian Tian, Jin-Ming Gao, Jiang-Jiang Tang|2024|Phytochemistry|218|113951|doi:10.1016/j.phytochem.2023.113951
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f4wl2
title: CCDC 2239024: Experimental Crystal Structure Determination

description: Related Article: Laxmikant D. Gangnale, Satya Ravi Teja Miriyala, Kalyan Kumar Pasunooti, D. Srinivasa Reddy|2023|J.Org.Chem.|88|17330|doi:10.1021/acs.joc.3c02157
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f4wm3
title: CCDC 2239025: Experimental Crystal Structure Determination

description: Related Article: Laxmikant D. Gangnale, Satya Ravi Teja Miriyala, Kalyan Kumar Pasunooti, D. Srinivasa Reddy|2023|J.Org.Chem.|88|17330|doi:10.1021/acs.joc.3c02157
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5255/ukda-sn-856834
title: Market Survey of Food and Beverage Purchase Behaviours, Commodity Packaging and Plastics in Off-Grid Greater Accra, Ghana and Kisumu, Kenya, 2021

description: This data set comprises a market survey of foods and beverages
and their packaging as sold at a sample of retail outlets in
urban Greater Accra, Ghana and Kisumu, Kenya. It also
comprises responses to a short shopper questionnaire and
all data were collected in areas classified as slums. The data
set was collected with the aim of quantifying packaging
waste associated with food and beverage purchases. It also
aimed to develop and evaluate a low-cost method for
identifying plastic resin types in resource-poor settings
lacking laboratory facilities. At each sampled retail outlet,
observations were made of vendor or consumer packaging
behaviours when food or beverage purchases took place.
Short interviews were conducted with shoppers. Where
foods or beverages were wrapped in plastics, packaging
samples were collected and further characterised in a basic
laboratory. Alongside recording labelling and other
packaging characteristics, the laboratory protocol also
completed a simple observation checklist (e.g. testing if
packaging floated; how it behaved on cutting), so as to infer
the packaging's plastic resin type. The data set should thus
be of interest to researchers wishing to understand waste
generation and packaging in urban Africa.
DOI: 10.6084/m9.figshare.24936339
title: Supplementary materials: Single-arm oncology trials and the nature of external controls arms

description: <b>This is a peer-reviewed supplementary table for the article '</b><b>Single-arm oncology trials and the nature of external controls arms</b><b>' published in the </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b><b>Supplementary Table 1:</b> Comparing cancer types of focus among the 15 example studies.<b>Summary: </b><b>Aim:</b> Single-arm trials with external control arms (ECAs) have gained popularity in oncology. ECAs may consist of primary data from previous trials, electronic health records (EHRs) or aggregate data from the literature. We sought to provide a description of how such studies achieve similarity of patients, comparability of data quality and outcome assessment. <b>Materials & methods:</b> In a stratified convenience sample of 15 studies, five used primary data from trials as ECAs, five used secondary data from EHRs and five used aggregate data from the literature. Data were collected from the published literature and public web resources, blinded to the eventual approval decision. <b>Results:</b> Studies using ECAs from primary data and EHR data displayed methods to achieve comparability of information, including matched baseline characteristics. Aggregate data from published studies did not attempt to match covariates. The EHR controls often showed calendar time overlap for collecting information while trial data were mostly historic. Outcome data were not consistently reported across studies. US FDA approval was only seen when primary data from trials or EHR data were used as the ECA, however no ECA in this sample directly contributed to approval. <b>Discussion:</b> In this nonsystematic review of ECAs for single-arm trials, the ECAs derived from primary data collected by other trials or EHRs show patterns of patient comparability, time overlap, and realistic methodological approaches to achieving balance between treatment arms. They are often submitted to regulators while literature-derived aggregate findings as ECA may serve as benchmarks for pipeline decisions.