DOI: 10.5061/dryad.9zw3r22jw
title: Data from: Exploratory study evaluating the relationships between perinatal adversity, oxidative stress, and infant neurodevelopment across the first year of life data

description: Early childhood adversity increases risk for negative lifelong impacts on
 health and wellbeing. Identifying the risk factors and the associated
 biological adaptations early in life is critical to develop scalable early
 screening tools and interventions. Currently, there are limited, reliable
 early childhood adversity measures that can be deployed prospectively, at
 scale, to assess risk in pediatric settings. The goal of this two-site
 study was to determine if the gold standard measure of oxidative stress,
 F2-Isoprostanes, is potentially a reliable measure of a physiological
 response to adversity of the infant and mother. The study evaluated the
 independent relationships between F2-Isoprostanes, perinatal adversity and
 infant neurocognitive development. The study included mother-infant dyads
 born &gt;36 weeks’ gestation. Maternal demographic information and
 mental health assessments were utilized to generate a perinatal cumulative
 risk score.  Infants’ development was assessed at 6 and 12 months
 and both mothers and infants were assayed for F2-isoprostane levels in
 blood and urine, respectively. Statistical analysis revealed that
 cumulative risk scores correlated with higher maternal (p=0.01) and infant
 (p=0.05) F2-isoprostane levels at 6 months. Infant F2-isoprostane measures
 at 2 months were negatively associated with Mullen Scales of Early
 Learning Composite scores at 12 months (p=0.04). Lastly, higher cumulative
 risk scores predicted higher average maternal F2-isoprostane levels across
 the 1 year study time period (p=0.04).The relationship between perinatal
 cumulative risk scores and higher maternal and infant F2-isoprostanes at 6
 months may reflect an oxidative stress status that informs a sensitive
 period in which a biomarker can be utilized prospectively to reveal the
 physiological impact of early adversity.
description: # Data from: Exploratory study evaluating the relationships between
 perinatal adversity, oxidative stress, and infant neurodevelopment across
 the first year of life This dataset includes the following variables that
 were used in the analysis: * ID (de-identified participant ID) * Site
 (de-identified study site) * Excluded (participants excluded from data
 analysis) * marital_status (marital status):
 (1-single,2-married,3-cohabitating,4-widowed,5-separated,6-divorced,
 99-did not respond) * m_education (mom education): (1-8th grade of less,
 2-some high school, 3-high school/GED, 4-associate degree,
 5-bachelor's degree, 6-master's degree, 7-MD, JD, PhD or
 equivalent, 99-I do not wish to disclose) * family_income (family income):
 (1-less than 5K,2-5k-11999K,
 3-12k-15999K,4-16k-24999,5-25K-34999,6-35K-49999,7-50k-74999,8-75K-99999,9-100K+,10-I don't know, 99-I do not wish to disclose) These variables are repeated at 2 months, 6 months, 9 months, and in total: * phq_#m_tot  (patient health questionnaire total score a # months): Score range 0-27 * epds_#m_tot  (edinburgh postnatal depression scale total score at # months): Score range 0-30 * pss_#m_tot (percieved stress scale total score at # months): Score range 0-40 * m2_elc_sscore (mullen early learning composite standard score at # months):Mean 100, standard Deviation 15 * isop_#m (child urine isoprostane values ng/mg Cr at # months) * isop_mat_#m (maternal blood plasma isoprostane values ng/mL at # months) Note: empty cells represent information not provided by the participant and are counted as missing data. For biosamples collected from participants, empty cells represent missing data. ## Human subjects data We received explicit consent from study participants to publish the de-identified data in the public domain. We removed signifying information like location, coded the study participant ID's, and all other identifying information.