cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29178833.v1
title: Supplementary Material for: Longitudinal Decrease in Left Ventricular Size with Age: Impact on Mortality and Cardiovascular Hospitalization

description: Background: A small left ventricular (LV) chamber size may reflect adverse cardiac remodeling and have prognostic implications. The prognostic significance of reductions in LV size in hearts with normal baseline LV size remains unclear. This study investigated clinical characteristics and outcomes associated with longitudinal decreases in LV size in this population.
Methods: We analyzed echocardiographic data from 6,232 adults with normal baseline left ventricular end-diastolic diameter (LVEDD), with a mean interval of 4.8 years between baseline and follow-up echocardiograms. Participants were categorized by LVEDD change from baseline: No Change (&lt;5 mm), Decreased (≥5 mm), and Increased (≥5 mm).
Results: A decrease in LVEDD was observed in 24% of participants (mean change -9±3 mm) and was significantly associated with older age, female sex, decreased volumes, concentric remodeling and diastolic dysfunction. LVEDD increase (13%, 9±4 mm) was associated with higher prevalence of cardiovascular comorbidities and reduced LVEF. Multivariable Cox regression showed decreased LVEDD was independently associated with increased mortality (HR 1.19, 95% CI 1.03-1.37, p=0.02). Sensitivity analysis using annual LVEDD change (&gt;1mm/year) demonstrated a significant association with mortality (HR 1.45, 95% CI 1.26-1.66, p&lt;0.001) and the combined endpoint of death/cardiovascular hospitalization (HR 1.26, 95% CI 1.12-1.41, p&lt;0.001). Restricted cubic spline analysis confirmed a U-shaped relationship between continuous LVEDD change and mortality. Furthermore, increase or decrease in left ventricular end-diastolic volumes were associated with increased mortality and death/cardiovascular hospitalization.
Conclusions: A progressive decrease in LVEDD in normal-sized hearts was independently associated with adverse outcomes, highlighting the prognostic importance of declining LV size.
DOI: 10.17898/10026/1
title: studies_kuha_web.xls

description: :unav
DOI: 10.17898/10026/10
title: SUF_CC0.txt

description: :unav
DOI: 10.17898/10026/14
title: 1_scuf.txt

description: :unav
DOI: 10.17898/10026/6
title: PUF_CCBYNC.txt

description: :unav
DOI: 10.17898/10026/8
title: SUF_CCBYNC.txt

description: :unav
DOI: 10.22033/esgf/cmip6.13801
title: IPSL IPSL-CM6A-LR model output prepared for CMIP6 DAMIP

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.DAMIP.IPSL.IPSL-CM6A-LR' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The IPSL-CM6A-LR climate model, released in 2017, includes the following components:
 atmos: LMDZ (NPv6, N96; 144 x 143 longitude/latitude; 79 levels; top level 80000 m), land: ORCHIDEE (v2.0, Water/Carbon/Energy mode), ocean: NEMO-OPA (eORCA1.3, tripolar primarily 1deg; 362 x 332 longitude/latitude; 75 levels; top grid cell 0-2 m), ocnBgchem: NEMO-PISCES, seaIce: NEMO-LIM3. 
The model was run by the Institut Pierre Simon Laplace, Paris 75252, France (IPSL) in native nominal resolutions: atmos: 250 km, land: 250 km, ocean: 100 km, ocnBgchem: 100 km, seaIce: 100 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.22033/esgf/cmip6.13831
title: IPSL IPSL-CM6A-LR model output prepared for CMIP6 DAMIP hist-nat

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.DAMIP.IPSL.IPSL-CM6A-LR.hist-nat' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The IPSL-CM6A-LR climate model, released in 2017, includes the following components:
 atmos: LMDZ (NPv6, N96; 144 x 143 longitude/latitude; 79 levels; top level 80000 m), land: ORCHIDEE (v2.0, Water/Carbon/Energy mode), ocean: NEMO-OPA (eORCA1.3, tripolar primarily 1deg; 362 x 332 longitude/latitude; 75 levels; top grid cell 0-2 m), ocnBgchem: NEMO-PISCES, seaIce: NEMO-LIM3. 
The model was run by the Institut Pierre Simon Laplace, Paris 75252, France (IPSL) in native nominal resolutions: atmos: 250 km, land: 250 km, ocean: 100 km, ocnBgchem: 100 km, seaIce: 100 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.22033/esgf/cmip6.3035
title: BCC BCC-CSM2MR model output prepared for CMIP6 ScenarioMIP ssp370

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.ScenarioMIP.BCC.BCC-CSM2-MR.ssp370' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The BCC-CSM 2 MR climate model, released in 2017, includes the following components:
 atmos: BCC_AGCM3_MR (T106; 320 x 160 longitude/latitude; 46 levels; top level 1.46 hPa), land: BCC_AVIM2, ocean: MOM4 (1/3 deg 10S-10N, 1/3-1 deg 10-30 N/S, and 1 deg in high latitudes; 360 x 232 longitude/latitude; 40 levels; top grid cell 0-10 m), seaIce: SIS2. 
The model was run by the Beijing Climate Center, Beijing 100081, China (BCC) in native nominal resolutions: atmos: 100 km, land: 100 km, ocean: 50 km, seaIce: 50 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.22033/esgf/cmip6.3694
title: CCCma CanESM5 model output prepared for CMIP6 ScenarioMIP ssp534-over

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.ScenarioMIP.CCCma.CanESM5.ssp534-over' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The CanESM5 climate model, released in 2019, includes the following components:
 aerosol: interactive, atmos: CanAM5 (T63L49 native atmosphere, T63 Linear Gaussian Grid; 128 x 64 longitude/latitude; 49 levels; top level 1 hPa), atmosChem: specified oxidants for aerosols, land: CLASS3.6/CTEM1.2, landIce: specified ice sheets, ocean: NEMO3.4.1 (ORCA1 tripolar grid, 1 deg with refinement to 1/3 deg within 20 degrees of the equator; 361 x 290 longitude/latitude; 45 vertical levels; top grid cell 0-6.19 m), ocnBgchem: Canadian Model of Ocean Carbon (CMOC); NPZD ecosystem with OMIP prescribed carbonate chemistry, seaIce: LIM2. 
The model was run by the Canadian Centre for Climate Modelling and Analysis, Environment and Climate Change Canada, Victoria, BC V8P 5C2, Canada (CCCma) in native nominal resolutions: aerosol: 500 km, atmos: 500 km, atmosChem: 500 km, land: 500 km, landIce: 500 km, ocean: 100 km, ocnBgchem: 100 km, seaIce: 100 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.22033/esgf/cmip6.3814
title: CMCC CMCC-CM2-VHR4 model output prepared for CMIP6 HighResMIP highresSST-present

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.HighResMIP.CMCC.CMCC-CM2-VHR4.highresSST-present' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The CMCC-CM2-VHR4 climate model, released in 2017, includes the following components:
 aerosol: prescribed MACv2-SP, atmos: CAM4 (1/4deg; 1152 x 768 longitude/latitude; 26 levels; top at ~2 hPa), land: CLM4.5 (SP mode), ocean: NEMO3.6 (ORCA0.25 1/4 deg from the Equator degrading at the poles; 1442 x 1051 longitude/latitude; 50 vertical levels; top grid cell 0-1 m), seaIce: CICE4.0. 
The model was run by the Fondazione Centro Euro-Mediterraneo sui Cambiamenti Climatici, Lecce 73100, Italy (CMCC) in native nominal resolutions: aerosol: 25 km, atmos: 25 km, land: 25 km, ocean: 25 km, seaIce: 25 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.22033/esgf/cmip6.3923
title: CNRM-CERFACS CNRM-CM6-1-HR model output prepared for CMIP6 CMIP amip

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.CMIP.CNRM-CERFACS.CNRM-CM6-1-HR.amip' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The CNRM-CM6-1-HR climate model, released in 2017, includes the following components:
 aerosol: prescribed monthly fields computed by TACTIC_v2 scheme, atmos: Arpege 6.3 (T359; Gaussian Reduced with 181724 grid points in total distributed over 360 latitude circles (with 720 grid points per latitude circle between 32.2degN and 32.2degS reducing to 18 grid points per latitude circle at 89.6degN and 89.6degS); 91 levels; top level 78.4 km), atmosChem: OZL_v2, land: Surfex 8.0c, ocean: Nemo 3.6 (eORCA025, tripolar primarily 1/4deg; 1442 x 1050 longitude/latitude; 75 levels; top grid cell 0-1 m), seaIce: Gelato 6.1. 
The model was run by the CNRM (Centre National de Recherches Meteorologiques, Toulouse 31057, France), CERFACS (Centre Europeen de Recherche et de Formation Avancee en Calcul Scientifique, Toulouse 31057, France) (CNRM-CERFACS) in native nominal resolutions: aerosol: 100 km, atmos: 100 km, atmosChem: 100 km, land: 100 km, ocean: 25 km, seaIce: 25 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.6084/m9.figshare.29178836
title: Supplementary Material for: Targeted Clinical Analysis of PTPN11, SOS1, and NRAS Mutations and Associated Cardiac, Auditory, and Ophthalmologic Findings in Noonan Syndrome Patients

description: Background: Noonan Syndrome (NS) is a genetic disorder inherited as an autosomal dominant or sporadic trait, characterized by distinctive facial features, congenital heart defects, short stature, mental retardation, and sensory impairments. The aim was to investigate the clinical correlations of selected variants in the PTPN11, SOS1, and NRAS genes with ophthalmologic, audiologic, and psychometric findings in patients clinically diagnosed with NS. 
Methods: Thirty-two patients (8 females and 24 males) clinically diagnosed with NS and aged between 6 months and 18 years were included. Genetic testing was performed for PTPN11, SOS1, and NRAS genes. Patients underwent standardized examinations by the same ophthalmologist, audiologist, and psychologist. A comprehensive database of findings was created, and statistical analyses were performed using SPSS 17.
Results: Molecular analysis revealed variants in PTPN11 gene in 37.5% (12/32), SOS1 related variants in 9.4% (3/32), and NRAS related variant in 3.1% (1/32). Ophthalmologic assessments indicated astigmatism in 8 patients and myopia in 5. Hearing loss was identified in 21.9% (7/32) of the cohort, with two PTPN11 and one NRAS mutation-positive patients affected. Psychometric evaluations showed mental retardation in 40.6% (13/32), with a significant proportion of PTPN11 mutation-positive patients affected. 
Conclusion: The study found no significant relationships between genetic mutations and ophthalmologic, audiologic, or psychometric outcomes. Further investigations with larger sample sizes are necessary to elucidate the genotype-phenotype correlations in NS.
DOI: 10.17898/10026/15
title: 0_puf.txt

description: :unav
DOI: 10.17898/10026/18
title: Baza usposabljanj-za-ADP(1).xls

description: :unav
DOI: 10.17898/10026/3
title: Odprti_CCBY.txt

description: :unav
DOI: 10.22033/esgf/cmip6.1944
title: CAS CAS-ESM2.0 model output prepared for CMIP6 CMIP

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.CMIP.CAS.CAS-ESM2-0' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The CAS-ESM 2.0 (Chinese Academy of Sciences Earth System Model version 2.0) climate model, released in 2019, includes the following components:
 aerosol: IAP AACM, atmos: IAP AGCM 5.0 (Finite difference dynamical core; 256 x 128 longitude/latitude; 35 levels; top level 2.2 hPa), atmosChem: IAP AACM, land: CoLM, ocean: LICOM2.0 (LICOM2.0, primarily 1deg; 362 x 196 longitude/latitude; 30 levels; top grid cell 0-10 m), ocnBgchem: IAP OBGCM, seaIce: CICE4. 
The model was run by the Chinese Academy of Sciences, Beijing 100029, China (CAS) in native nominal resolutions: aerosol: 100 km, atmos: 100 km, atmosChem: 100 km, land: 100 km, ocean: 100 km, ocnBgchem: 100 km, seaIce: 100 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.
DOI: 10.22033/esgf/cmip6.3017
title: BCC BCC-ESM1 model output prepared for CMIP6 CMIP piControl

description: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets: These data include all datasets published for 'CMIP6.CMIP.BCC.BCC-ESM1.piControl' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'.
 
 The BCC-ESM 1 climate model, released in 2017, includes the following components:
 atmos: BCC_AGCM3_LR (T42; 128 x 64 longitude/latitude; 26 levels; top level 2.19 hPa), atmosChem: BCC-AGCM3-Chem, land: BCC_AVIM2, ocean: MOM4 (1/3 deg 10S-10N, 1/3-1 deg 10-30 N/S, and 1 deg in high latitudes; 360 x 232 longitude/latitude; 40 levels; top grid cell 0-10 m), seaIce: SIS2. 
The model was run by the Beijing Climate Center, Beijing 100081, China (BCC) in native nominal resolutions: atmos: 250 km, atmosChem: 250 km, land: 250 km, ocean: 50 km, seaIce: 50 km. 

Project: These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6).

CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ).

The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. - Project website: https://pcmdi.llnl.gov/CMIP6.