cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25550/1-x5jg
title: Gene summary for Gli2

description: ### Gene expression in the mandibular and maxillary arches _Gli2_ is expressed in the mesenchyme of the maxillary and mandibular arches at E10.5. In the mandibular arch, the most proximal region does not express Gli2. At E12.5, it is expressed in the osteogenic and odontogenic mesenchyme of maxilla and mandible. At E14.5, Gli2 is expressed in differentiated osteoblasts of maxilla and mandible, oral mesenchyme of the palate, tooth mesenchyme, and tongue. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/gli2-10.5.jpg){width=190 height=145} | ![ImageWithSize](/hatrac/facebase/genesummaries/gli2-12.5.jpg){width=190 height=145} | ![ImageWithSize](/hatrac/facebase/genesummaries/gli2-14.5.jpg){width=190 height=145} | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Maxillary mesenchyme and | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Maxillary and mandibular | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Differentiated osteoblasts | | distal mandibular mesenchyme | mesenchyme | in mandible and maxilla | | | | ![Image](/hatrac/facebase/genesummaries/755f8e.gif) Oral palatal mesenchyme | | | | ![Image](/hatrac/facebase/genesummaries/ece6f0.gif) Tooth mesenchyme | #### Sources: - Bai CB et al., Development. 2001 Dec;128(24):5161-72. - Gray PA et al., Science. 2004 Dec 24;306(5705):2255-7. - Hardcastle Z, et al., Development. 1998 Aug;125(15):2803-11 - Hui CC, et al., Dev Biol. 1994 Apr;162(2):402-13 - Mo R, et al., Development. 1997 Jan;124(1):113-23 - Rice R, et al., Gene Expr Patterns. 2006 Jan;6(2):206-12 - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/).
DOI: 10.25550/1-x5jr
title: Gene summary for Gli3

description: ### Gene expression in the mandibular and maxillary arches _Gli3_ is expressed in the mesenchyme of the maxillary and mandibular arches at E10.5. At E12.5, it is expressed in mandibular mesenchyme, including Meckel’s cartilage, tongue mesenchyme, and oral region of the palate. At E14.5, Gli3 is expressed in the odontogenic mesenchyme of maxilla and mandible, differentiated osteoblasts of maxilla and mandible, oral mesenchyme of the palate, tongue, sublingual muscles, and masticatory muscles. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/genesummary/images/gli3/gli3-10.5.jpg){width=280 height=214} | ![ImageWithSize](/genesummary/images/gli3/gli3-12.5.jpg){width=280 height=214} | ![ImageWithSize](/genesummary/images/gli3/gli3-14.5.jpg){width=280 height=214} | | ![Image](/genesummary/legend/c1b2d1.gif) Maxillary and mandibular | ![Image](/genesummary/legend/c1b2d1.gif) Mandibular mesenchyme, | ![Image](/genesummary/legend/524364.gif) Oral palatal mesenchyme | | mesenchyme | tongue mesenchyme, and | ![Image](/genesummary/legend/755f8e.gif) Tongue muscles and masticatory muscles | | | oral region of the palate | ![Image](/genesummary/legend/c1b2d1.gif) Differentiated osteoblasts | | | | of mandible and maxilla | | | | ![Image](/genesummary/legend/ece6f0.gif) Tooth mesenchyme | #### Sources: - Hui CC, et al., Dev Biol. 1994 Apr;162(2):402-13 - Mo R, et al., Development. 1997 Jan;124(1):113-23 - Rice R, et al., Gene Expr Patterns. 2006 Jan;6(2):206-12 - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/).
DOI: 10.25550/1-x5k0
title: Gene summary for Hand2

description: ### Gene expression in the mandibular and maxillary arches _Hand2_ is expressed in the distal mesenchyme of the mandibular arch at E10.5. At E12.5, it is expressed in the osteogenic mesenchyme adjacent to the Meckel’s cartilage, and the tongue mesenchyme. At E14.5, _Hand2_ is expressed in the differentiated osteoblasts of the mandible, the tongue mesenchyme, and the sublingual muscles. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/hand2-10.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/hand2-12.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/hand2-14.5.jpg){width=280 height=214} | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Distal mandibular | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Osteogenic progenitors | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Mandibular differentiated | | mesenchyme | adjacent to Meckel’s cartilage | osteoblasts | | | ![Image](/hatrac/facebase/genesummaries/755f8e.gif) Tongue mesenchyme | ![Image](/hatrac/facebase/genesummaries/755f8e.gif) Tongue mesenchyme | | | | ![Image](/hatrac/facebase/genesummaries/524364.gif) Sublingual muscles | #### Sources: - Funato N et al., Development 2009 136: 615-625 - Ruest LB, et al., Dev Biol. 2003 May 15;257(2):263-77 - Clouthier DE, et al., Dev Biol. 2000 Jan 1;217(1):10-24 - Diez-Roux G, et al., PLoS Biol. 2011;9(1):e1000582 - Ikle JM, et al., Dev Biol. 2012 Aug 1;368(1):118-26 - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/).
DOI: 10.25550/1-x5kr
title: Gene summary for Osr2

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=OSR2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=OSR2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=OSR2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=OSR2) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Osr2_anterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Osr2_anterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Osr2_anterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Osr2_anterior_E15.5.jpg) | ### Gene expression in the secondary palate _Osr2_ is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Osr2_coronal_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Osr2_coronal_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Osr2_oral_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Osr2_oral_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/C0B6D1.gif) Oral mesenchyme ![Image](/hatrac/facebase/genesummaries/ECB177.gif) Anterior mesenchyme (AP axis) #### Sources: - Lan et al. (2004) [Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis.](http://www.ncbi.nlm.nih.gov/pubmed/15175245) Development 131(13): 3207-16. ### External Links - [Osr2 odd-skipped related 2 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/107587) - [Osr2 odd-skipped related 2 (Drosophila) [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/116039) - [Osr2 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=OSR2&search=osr2) - [Osr2 Wikipedia](http://en.wikipedia.org/wiki/OSR2_(gene))
DOI: 10.25550/1-x5m0
title: Gene summary for Pax9

description: ### Gene expression in the mandibular and maxillary arches _Pax9_ is expressed in the odontogenic mesenchyme at E10.5 and E12.5. At E12.5, it is also expressed in the tongue. At E14.5, it is expressed in the odontogenic mesenchyme, Meckel’s cartilage, differentiated osteoblasts in maxilla and mandible, oral and medial regions of the palate, tongue muscles and mesenchyme, and sublingual muscles. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/pax9-10.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/pax9-12.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/pax9-14.5.jpg){width=280 height=214} | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Odontogenic mesenchyme | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Odontogenic mesenchyme | ![Image](/hatrac/facebase/genesummaries/524364.gif) Oral and medial | | | and tongue | palatal mesenchyme | | | | ![Image](/hatrac/facebase/genesummaries/755f8e.gif) Tongue and sublingual | | | | muscles | | | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Differentiated osteoblasts | | | | in mandible and maxilla | | | | ![Image](/hatrac/facebase/genesummaries/ece6f0.gif) Tooth mesenchyme | #### Sources: - Diez-Roux G, et al., PLoS Biol. 2011;9(1):e1000582 - Gray PA, et al., Science. 2004 Dec 24;306(5705):2255-2257 - ten Berge D, et al., Development. 1998 Oct;125(19):3831-42 - Aberg T, et al., Dev Biol. 2004 Jun 1;270(1):76-93 - Beverdam A, et al., Development. 2001 Oct;128(20):3975-86 - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/).
DOI: 10.25550/1-x5m8
title: Gene summary for Pitx2

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=PITX2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=PITX2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=PITX2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=PITX2) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Pitx2_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Pitx2_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Pitx2_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Pitx2_posterior_E15.5.jpg) | ### Gene expression in the secondary palate At E13.5, _Pitx2_ is expressed in the palatal epithelium along the AP axis. At E14.5, _Pitx2_ is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif) | ![ImageWithSize](/hatrac/facebase/genesummaries/Pitx2_coronal_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Pitx2_coronal_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif) | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif) | ![ImageWithSize](/hatrac/facebase/genesummaries/Pitx2_oral_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Pitx2_oral_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif) | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/FFFB76.gif) Osteogenic mesenchyme ![Image](/hatrac/facebase/genesummaries/8FBDCD.gif) All mesenchyme (AP axis) ![Image](/hatrac/facebase/genesummaries/legend_blue_line.png) All epithelium #### Sources: - Iwata et al. (2012) [Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis.](http://www.ncbi.nlm.nih.gov/pubmed/22123828) J. Biol. Chem. 287(4):2353-63. ### External Links - [Pitx2 paired-like homeodomain transcription factor 2 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/18741) - [Pitx2 paired-like homeodomain 2 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/5308) - [Pitx2 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=PITX2&search=pitx2) - [Pitx2 Wikipedia](http://en.wikipedia.org/wiki/PITX2)
DOI: 10.25550/1-x5mg
title: Gene summary for Prrx1

description: ### Gene expression in the mandibular and maxillary arches _Prrx1_ is expressed in the maxillary arch and the distal region of the mandibular arch at E10.5. At E12.5 and E14.5, _Prrx1_ is expressed throughout the mesenchyme of both maxilla and mandible. The tongue is negative at both stages. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/prrx1-10.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/prrx1-12.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/prrx1-14.5.jpg){width=280 height=214} | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Distal mesenchyme | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Odontogenic and osteogenic | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Osteogenic mesenchyme | | | mesenchyme | | #### Sources: - Jackson Lab. - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/).
DOI: 10.25550/1-x5mr
title: Gene summary for Runx2

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=RUNX2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=RUNX2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=RUNX2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=RUNX2) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Runx2_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Runx2_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Runx2_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Runx2_posterior_E15.5.jpg) | ### Gene expression in the secondary palate At E13.5 and E15.5, _Runx2_ is expressed in the osteogenic mesenchyme along the AP axis. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Runx2_coronal_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Runx2_coronal_E15.5_0.jpg){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Runx2_oral_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Runx2_oral_E15.5_0.jpg){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/FFFB76.gif) Osteogenic mesenchyme ![Image](/hatrac/facebase/genesummaries/8FBDCD.gif) All mesenchyme (AP axis) #### Sources: - Yamashiro et al. (2002) [Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development.](http://www.ncbi.nlm.nih.gov/pubmed/14516670) Mech. Dev. 119 Suppl 1:S107-10. - Baek et al. (2011) [Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.](http://www.ncbi.nlm.nih.gov/pubmed/21185278) Dev. Biol. 350(2):520-31. ### External Links - [Runx2 runt related transcription factor 2 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/12393) - [Runx2 runt-related transcription factor 2 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/860) - [Runx2 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=RUNX2&search=runx2) - [Runx2 Wikipedia](http://en.wikipedia.org/wiki/RUNX2)
DOI: 10.25550/1-x5n0
title: Gene summary for Shox2

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=SHOX2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=SHOX2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=SHOX2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=SHOX2) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Shox2_anterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Shox2_anterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Shox2_anterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Shox2_anterior_E15.5.jpg) | ### Gene expression in the secondary palate _Shox2_ is expressed in the mesenchyme of the anterior region of the developing palate, on both nasal and oral sides. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Shox2_coronal_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Shox2_coronal_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Shox2_coronal_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Shox2_oral_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Shox2_oral_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Shox2_oral_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/blank.gif){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/FD8873.gif) All mesenchyme (ON axis) ![Image](/hatrac/facebase/genesummaries/ECB177.gif) Anterior mesenchyme (AP axis) #### Sources: - Yu et al. (2005) [Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate.](http://www.ncbi.nlm.nih.gov/pubmed/14516670) Development 132(19): 4397-406. ### External Links - [Shox2 short stature homeobox 2 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/20429) - [Shox2 short stature homeobox 2 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/6474) - [Shox2 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=SHOX2&search=shox2) - [Shox2 Wikipedia](http://en.wikipedia.org/wiki/SHOX2)
DOI: 10.25550/1-x5ng
title: Gene summary for Tbx1

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=TBX1) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=TBX1) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=TBX1) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=TBX1) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Tbx1_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Tbx1_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Tbx1_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Tbx1_posterior_E15.5.jpg) | ### Gene expression in the secondary palate At E12.5, _Tbx1_ expression appears in the epithelium of the most posterior domain of the palatal shelf. _Tbx1_ is expressed in the medial and posterior edge of the secondary palate before and after fusion. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_coronal_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_coronal_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_coronal_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_coronal_E15.5_0.jpg){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_oral_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_oral_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_oral_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tbx1_oral_E15.5_0.jpg){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/legend_blue_line.png) All epithelium #### Sources: - Funato et al. (2012) [Tbx1 regulates oral epithelial adhesion and palatal development.](http://www.ncbi.nlm.nih.gov/pubmed/22371266) Hum. Mol. Genet. 21(11):2524-37. - Unpublished data from [Chai Lab, University of Southern California](http://face.usc.edu). ### External Links - [Tbx1 T-box 1 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/21380) - [Tbx1 T-box 1 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/6899) - [Tbx1 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=TBX1&search=tbx1) - [Tbx1 Wikipedia](http://en.wikipedia.org/wiki/TBX1)
DOI: 10.25550/1-x5nr
title: Gene summary for Tgfb3

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=TGFB3) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=TGFB3) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=TGFB3) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=TGFB3) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Tgfb3_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Tgfb3_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Tgfb3_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Tgfb3_posterior_E15.5.jpg) | ### Gene expression in the secondary palate _Tgfb3_ is expressed in the midline epithelium before the palatal shelves have contact in the midline (E14.0) until the complete disappearance of the MEE (E15.5). | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_coronal_E12.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_coronal_E13.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_coronal_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_coronal_E15.5_0.jpg){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_oral_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_oral_E13.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_oral_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Tgfb3_oral_E14.5_0.jpg){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/legend_brown_line.png) Midline epithelium #### Sources: - Yang LT, Li LY & Kaartinen V, 2008. [Tissue-specific expression of Cre recombinase from the Tgfb3 locus.](http://www.ncbi.nlm.nih.gov/pubmed/18257072) Genesis 46(2):112-8. - Jackson Laboratories. - Immunostaining. Unpublished data from [Chai Lab, University of Southern California](http://face.usc.edu). ### External Links - [Tgfb3 transforming growth factor, beta 3 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/21809) - [Tgfb3 transforming growth factor, beta 3 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/7043) - [Tgfb3 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=TGFB3&search=tgfb3) - [Tgfb3 Wikipedia](http://en.wikipedia.org/wiki/TGFB3)