cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q24b30xj
title: BindingDB Entry 50017721: Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.

description: Small molecule binding data for protein C-C chemokine receptor type 5, Cytochrome P450 1A1, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and Voltage-gated potassium channel, Uniprot P04798, P08684, P10635, P11712, P33261, P51681, and Q12809
DOI: 10.7270/q2513xmw
title: BindingDB Entry 50014180: Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists.

description: Small molecule binding data for protein Neuropeptide Y receptor type 1 and Neuropeptide Y receptor type 5 ( NPY Y5), Uniprot P25929 and Q15761
DOI: 10.7270/q26h4gx2
title: BindingDB Entry 50015835: Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.

description: Small molecule binding data for protein Calpain1/2, Caspase-3, Caspase-6, Caspase-7, Caspase-8, and Caspase-9, Uniprot P07384, P42574, P55210, P55211, P55212, and Q14790
DOI: 10.7270/q27080s4
title: BindingDB Entry 50012189: N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.

description: Small molecule binding data for protein Angiotensin-converting enzyme, Endothelin-converting enzyme 1 (ECE1), and Neprilysin, Uniprot P08049, P42892, and P47820
DOI: 10.7270/q27s7n6x
title: BindingDB Entry 50014195: 2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor.

description: Small molecule binding data for protein Tyrosinase, Uniprot P14679
DOI: 10.7270/q280527z
title: BindingDB Entry 50017719: Development of lipopeptides for inhibiting 20S proteasomes.

description: Small molecule binding data for protein Proteasome Macropain subunit, Proteasome Macropain subunit PRE2, and Proteasome component C5, Uniprot P22141, P23724, and P30656
DOI: 10.7270/q28s4pb9
title: BindingDB Entry 50014179: Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.

description: Small molecule binding data for protein Fibronectin receptor beta/Integrin alpha-4, Uniprot P05556 and P13612
DOI: 10.7270/q2b857ns
title: BindingDB Entry 50015834: The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.

description: Small molecule binding data for protein C-C chemokine receptor type 3, Uniprot O54814, P51677, P51678, and P56483
DOI: 10.7270/q2br8rh5
title: BindingDB Entry 50012188: Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity.

description: Small molecule binding data for protein Serotonin (5-HT) receptor and Serotonin receptor 2a and 2c (5HT2A and 5HT2C), Uniprot P08909 and P14842
DOI: 10.7270/q2cr5szk
title: BindingDB Entry 50017718: Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring.

description: Small molecule binding data for protein Delta-type opioid receptor, Kappa-type opioid receptor, and Mu-type opioid receptor, Uniprot P35372, P41143, and P41145
DOI: 10.7270/q2g160b2
title: BindingDB Entry 50015832: Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives.

description: Small molecule binding data for protein Nitric oxide synthase, brain and Nitric oxide synthase, inducible, Uniprot P29475 and P35228
DOI: 10.7270/q2gf0sv5
title: BindingDB Entry 50012184: Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.

description: Small molecule binding data for protein Angiotensin II receptor, Uniprot P30556
DOI: 10.7270/q2gh9hjx
title: BindingDB Entry 50017731: Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).

description: Small molecule binding data for protein C-C chemokine receptor type 8, Cytochrome P450 3A, and Voltage-gated potassium channel, Uniprot P08684, P51685, and Q12809
DOI: 10.7270/q2h994mh
title: BindingDB Entry 50014193: Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.

description: Small molecule binding data for protein Histamine H1 receptor, Histamine H2 Receptor, Histamine H3 receptor, Histamine receptor (H3), and Histamine receptor (H4), Uniprot P25021, P35367, Q9H3N8, Q9QYN8, and Q9Y5N1
DOI: 10.7270/q2hh6jp9
title: BindingDB Entry 50017714: Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

description: Small molecule binding data for protein Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) and Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2), Uniprot P12268 and P20839
DOI: 10.7270/q2j965ts
title: BindingDB Entry 50014172: Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.

description: Small molecule binding data for protein Mu-type opioid receptor, Nociceptin/mu opioid receptor, Opioid receptor, Opioid receptors; mu & delta, and mu/kappa opioid receptor, Uniprot P33533, P33535, P34975, P42866, and P97266
DOI: 10.7270/q2js9pzr
title: BindingDB Entry 50015843: Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.

description: Small molecule binding data for protein Vascular endothelial growth factor receptor 2, Uniprot P35968
DOI: 10.7270/q2ks6r1n
title: BindingDB Entry 50015831: (R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.

description: Small molecule binding data for protein Melatonin receptor, Uniprot P48039 and P49286
DOI: 10.7270/q2m61jkw
title: BindingDB Entry 50012181: The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production.

description: Small molecule binding data for protein Nitric Oxide Synthase, inducible, Uniprot P29477
DOI: 10.7270/q2n29wc9
title: BindingDB Entry 50014192: Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.

description: Small molecule binding data for protein Prostaglandin G/H synthase (cyclooxygenase), Uniprot P05979
DOI: 10.7270/q2n879d1
title: BindingDB Entry 50017712: Design, synthesis, and biological evaluation of indole derivatives as novel nociceptin/orphanin FQ (N/OFQ) receptor antagonists.

description: Small molecule binding data for protein Nociceptin receptor, Uniprot P41146
DOI: 10.7270/q2p26xkk
title: BindingDB Entry 50014170: 4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide, an orally active inhibitor of 5-lipoxygenase with improved pharmacokinetic and toxicology characteristics.

description: Small molecule binding data for protein 5-lipoxygenase/FLAP, Uniprot P09917
DOI: 10.7270/q2qf8sdj
title: BindingDB Entry 50015820: Amino acid conjugates as kappa opioid receptor agonists.

description: Small molecule binding data for protein Kappa-type opioid receptor, Uniprot P41145
DOI: 10.7270/q2qz2999
title: BindingDB Entry 50012179: Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.

description: Small molecule binding data for protein Dual specificity phosphatase Cdc25B, Protein-tyrosine phosphatase 1B, Receptor-type tyrosine-protein phosphatase F (LAR), and Tyrosine-Protein Phosphatase (CD45), Uniprot P08575, P10586, P18031, and P30305
DOI: 10.7270/q2rv0n4q
title: BindingDB Entry 50014190: Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin alphaVbeta3.

description: Small molecule binding data for protein Fibronectin receptor beta/Integrin alpha-4, Fibronectin receptor beta/Integrin alpha5, Integrin alpha-IIb/beta-3, and Integrin beta-3/Vitronectin receptor alpha, Uniprot P05106, P05556, P06756, P08514, P08648, and P13612
DOI: 10.7270/q2t72gzk
title: BindingDB Entry 50015840: Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists.

description: Small molecule binding data for protein Gonadotropin releasing hormone 1 (GnRHR1), Uniprot P30968
DOI: 10.7270/q2vq3211
title: BindingDB Entry 50012168: Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres.

description: Small molecule binding data for protein Human immunodeficiency virus type 1 protease
DOI: 10.7270/q2wm1ctk
title: BindingDB Entry 50014188: Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

description: Small molecule binding data for protein Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) and Protein Farnesyltransferase (PFT) Chain B, Uniprot P49354, P49356, and P53609
DOI: 10.7270/q2ws8swt
title: BindingDB Entry 50017710: 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.

description: Small molecule binding data for protein Sphingosine 1-Phosphate Receptor 2, Sphingosine 1-Phosphate Receptor 4, Sphingosine 1-Phosphate Receptor 5, Sphingosine 1-phosphate receptor, and Sphingosine 1-phosphate receptor 3, Uniprot O95136, O95977, P21453, Q99500, and Q9H228
DOI: 10.7270/q20c4v5h
title: BindingDB Entry 50014197: A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.

description: Small molecule binding data for protein Histamine H3 receptor and Histamine receptor (H3), Uniprot Q9QYN8 and Q9Y5N1
DOI: 10.7270/q21r6q0g
title: BindingDB Entry 50015848: Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 2C (5-HT2C), and Serotonin receptor (2b and 2c), Uniprot P28223, P28335, and P41595
DOI: 10.7270/q22806xk
title: BindingDB Entry 50012206: Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.

description: Small molecule binding data for protein GRIK1, Glutamate-Kainate 7, Grik2, and Grik5, Uniprot P39086, Q13002, Q13003, and Q16478
DOI: 10.7270/q2348jsw
title: BindingDB Entry 50014212: Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors.

description: Small molecule binding data for protein Protein Farnesyltransferase (PFT) Chain B, Uniprot P49356
DOI: 10.7270/q23b5zrb
title: BindingDB Entry 50017737: Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.

description: Small molecule binding data for protein Beta amyloid A4 protein, Uniprot P05067
DOI: 10.7270/q2416whz
title: BindingDB Entry 50014196: Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases.

description: Small molecule binding data for protein Dual specificity protein phosphatase (VHR), Uniprot P51452
DOI: 10.7270/q25h7fr7
title: BindingDB Entry 50015847: Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor alpha/beta agonist scaffold.

description: Small molecule binding data for protein Estradiol receptor alpha (ERα) and Estradiol receptor beta (ERβ), Uniprot P03372 and Q92731
DOI: 10.7270/q2610znx
title: BindingDB Entry 50012205: SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

description: Small molecule binding data for protein MAP kinase p38 and Prostaglandin G/H synthase (cyclooxygenase), Uniprot P05979 and P47811
DOI: 10.7270/q2736qhh
title: BindingDB Entry 50017736: Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor, Uniprot P37231
DOI: 10.7270/q29886hd
title: BindingDB Entry 50015846: Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

description: Small molecule binding data for protein Heme Oxygenase 1 (HO-1) and Heme Oxygenase 2 (HO-2), Uniprot P06762 and P23711
DOI: 10.7270/q29s1qcb
title: BindingDB Entry 50012201: Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

description: Small molecule binding data for protein NADH-ubiquinone oxidoreductase subunit B14.7, Uniprot Q8HXG6
DOI: 10.7270/q2bk1brz
title: BindingDB Entry 50014209: Benzene-di-N-octylcarbamates as conformationally constrained phospholipase A(2) inhibitors.

description: Small molecule binding data for protein Phospholipase A2, major isoenzyme, Uniprot P00592
DOI: 10.7270/q2br8rsr
title: BindingDB Entry 50017734: Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.

description: Small molecule binding data for protein PKC alpha and beta-2, Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C theta type, Protein kinase C, epsilon, Protein kinase C, eta, and Protein kinase C, gamma, Uniprot P05129, P05771, P17252, P24723, Q02156, Q04759, and Q05655
DOI: 10.7270/q2cj8cws
title: BindingDB Entry 50014194: Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.

description: Small molecule binding data for protein 5-Hydroxytryptamine receptor 2A (5-HT2A), 5-Hydroxytryptamine receptor 7 (5-HT7), 5-hydroxytryptamine receptor 1A, and Dopamine receptor D2L/neurotensin receptor NTS1, Uniprot P08908, P14416, P28223, and P34969
DOI: 10.7270/q2f18z7r
title: BindingDB Entry 50015844: Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.

description: Small molecule binding data for protein Cannabinoid receptor 1, Uniprot P21554
DOI: 10.7270/q2fj2g32
title: BindingDB Entry 50012200: A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones.

description: Small molecule binding data for protein Gonadotropin releasing hormone 1 (GnRHR1), Uniprot P30968
DOI: 10.7270/q2gb23f7
title: BindingDB Entry 50014207: Fluorinated dihydroquinolines as potent n-NOS inhibitors.

description: Small molecule binding data for protein Nitric oxide synthase, brain, Nitric oxide synthase, inducible, and Nitric-oxide synthase (endothelial and brain), Uniprot P29475 and P35228
DOI: 10.7270/q2k64hd2
title: BindingDB Entry 50012198: Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists.

description: Small molecule binding data for protein Neurokinin 1 receptor and Neurokinin 2 receptor, Uniprot P21452 and P25103
DOI: 10.7270/q2m32v5k
title: BindingDB Entry 50014204: 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands.

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine receptor 1D, Uniprot P28221 and P28222
DOI: 10.7270/q2m90886
title: BindingDB Entry 50017729: Synthesis and SAR of alpha-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors.

description: Small molecule binding data for protein Collagenase, Matrix metalloproteinase-1 (MMP1), and Stromelysin-1, Uniprot P03956, P08253, P08254, P14780, and P45452
DOI: 10.7270/q2nk3dk3
title: BindingDB Entry 50015854: Structure-activity relationships of dimeric PPAR agonists.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor alpha (PPAR alpha) and Peroxisome proliferator-activated receptor delta (PPAR delta), Uniprot Q03181 and Q07869
DOI: 10.7270/q2pk0fnk
title: BindingDB Entry 50015842: Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.

description: Small molecule binding data for protein Acyl-CoA: cholesterol acyltransferase (ACAT), Anandamide amidohydrolase, and Fatty-acid amide hydrolase 1 (FAAH), Uniprot O00519, O08914, and P23141
DOI: 10.7270/q2pz584g
title: BindingDB Entry 50012197: Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification.

description: Small molecule binding data for protein Coagulation factor X/antithrombin III, Prothrombin, and Trypsin-1, Uniprot P00734, P00742, and P07477
DOI: 10.7270/q2q23zt9
title: BindingDB Entry 50017749: Synthesis of biphenyltrienes as probes for beta-amyloid plaques.

description: Small molecule binding data for protein Beta amyloid A4 protein, Uniprot P05067
DOI: 10.7270/q2qv3kx1
title: BindingDB Entry 50014202: Design of small molecule ketoamide-based inhibitors of cathepsin K.

description: Small molecule binding data for protein Cathepsin K, Uniprot O35186 and P43235
DOI: 10.7270/q2r2110x
title: BindingDB Entry 50017728: The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

description: Small molecule binding data for protein Estradiol receptor alpha (ERα) and Estradiol receptor beta (ERβ), Uniprot P03372 and Q92731
DOI: 10.7270/q2sb458c
title: BindingDB Entry 50015852: Aglycon specificity profiling of alpha-glucosidases using synthetic probes.

description: Small molecule binding data for protein Alpha-glucosidase, Uniprot Q17058
DOI: 10.7270/q2tq60vs
title: BindingDB Entry 50012193: The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.

description: Small molecule binding data for protein Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) and Protein Farnesyltransferase (PFT), Uniprot P49354, P49356, and P53609
DOI: 10.7270/q2tt4qjq
title: BindingDB Entry 50017748: Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.

description: Small molecule binding data for protein P-glycoprotein 1, Uniprot P08183
DOI: 10.7270/q2vm4bp6
title: BindingDB Entry 50014199: Inhibition of alpha-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion.

description: Small molecule binding data for protein Beta-chymotrypsin
DOI: 10.7270/q2vt1rqj
title: BindingDB Entry 50017726: 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.

description: Small molecule binding data for protein Delta-type opioid receptor, Kappa-type opioid receptor, Mu-type opioid receptor, and Nociceptin receptor, Uniprot P35372, P41143, P41145, and P41146
DOI: 10.7270/q2x066jx
title: BindingDB Entry 50015849: Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.

description: Small molecule binding data for protein Heat shock protein HSP90, Uniprot P07900
DOI: 10.7270/q2xg9qfr
title: BindingDB Entry 50012207: The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.

description: Small molecule binding data for protein Monoamine Oxidase Type B (MAO-B), Uniprot P19643
DOI: 10.7270/q2z037nv
title: BindingDB Entry 50015839: Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.

description: Small molecule binding data for protein Glucagon receptor, Uniprot P47871
DOI: 10.7270/q2zg6rk4
title: BindingDB Entry 50012192: 4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

description: Small molecule binding data for protein Coagulation factor X/antithrombin III, Plasminogen, Prothrombin, Tissue-type plasminogen activator, and Urokinase-type plasminogen activator, Uniprot P00734, P00742, P00747, P00749, and P00750
DOI: 10.7270/q20r9nxk
title: BindingDB Entry 50015863: Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

description: Small molecule binding data for protein Thymidylate Synthase (TS) and Thymidylate synthase, Uniprot P00469 and P04818
DOI: 10.7270/q21835tn
title: BindingDB Entry 50012220: Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II.

description: Small molecule binding data for protein Folylpoly-gamma-glutamate synthetase and Glutamate carboxypeptidase II, Uniprot P70627 and Q05932
DOI: 10.7270/q2251hn2
title: BindingDB Entry 50014222: Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G.

description: Small molecule binding data for protein Cathepsin G, Prothrombin, and Trypsin-1, Uniprot P00734, P07477, and P08311
DOI: 10.7270/q22b8xnd
title: BindingDB Entry 50017759: Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors.

description: Small molecule binding data for protein Cyclooxygenase, Uniprot P35354
DOI: 10.7270/q24j0dmd
title: BindingDB Entry 50015861: Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.

description: Small molecule binding data for protein G protein-coupled receptor 44, Prostanoid DP receptor, and Prostanoid TP receptor, Uniprot P21731, Q13258, and Q9Y5Y4
DOI: 10.7270/q2513xj0
title: BindingDB Entry 50012219: Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

description: Small molecule binding data for protein Gonadotropin-releasing hormone receptor, Uniprot P30968
DOI: 10.7270/q2639pc4
title: BindingDB Entry 50017758: Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors.

description: Small molecule binding data for protein Cathepsin (B and K), Cathepsin (H and K), Cathepsin L1, Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, and Dipeptidyl peptidase I, Uniprot P05177, P07711, P07858, P08684, P09668, P10635, P11712, P33261, and P53634
DOI: 10.7270/q26t0m23
title: BindingDB Entry 50014211: Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).

description: Small molecule binding data for protein Plasminogen activator inhibitor-1, Uniprot P05121
DOI: 10.7270/q28915ck
title: BindingDB Entry 50015859: (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors.

description: Small molecule binding data for protein LDL-associated phospholipase A2, Uniprot Q13093
DOI: 10.7270/q28s4p8d
title: BindingDB Entry 50012218: Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

description: Small molecule binding data for protein Gonadotropin-releasing hormone receptor, Uniprot P30968 and P30969
DOI: 10.7270/q29p312r
title: BindingDB Entry 50014220: 3-trifluoromethyl-4-nitro-5-arylpyrazoles are novel K(ATP) channel agonists.

description: Small molecule binding data for protein Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1, Uniprot Q09428 and Q14654
DOI: 10.7270/q29w0f33
title: BindingDB Entry 50017756: Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3.

description: Small molecule binding data for protein Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3 and Cyclin-Dependent Kinase 5 (CDK5), Uniprot O95067, P06493, P14635, Q00535, Q15078, and Q8WWL7
DOI: 10.7270/q2d21x4c
title: BindingDB Entry 50015856: Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.

description: Small molecule binding data for protein Estradiol receptor alpha (ERα) and Estradiol receptor beta (ERβ), Uniprot P03372 and Q92731