cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17120534
title: Additional file 6 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 6. GTEx top 1000 Gene Ontology. Gene Ontology enrichment for the top 1000 genes, whose expression across GTEx tissues is most positively correlated with tissue mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120534.v1
title: Additional file 6 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 6. GTEx top 1000 Gene Ontology. Gene Ontology enrichment for the top 1000 genes, whose expression across GTEx tissues is most positively correlated with tissue mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120537
title: Additional file 7 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 7. GTEx bottom 1000 Gene Ontology. Gene Ontology enrichment for the bottom 1000 genes, whose expression across GTEx tissues is most negatively correlated with tissue mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120537.v1
title: Additional file 7 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 7. GTEx bottom 1000 Gene Ontology. Gene Ontology enrichment for the bottom 1000 genes, whose expression across GTEx tissues is most negatively correlated with tissue mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120540
title: Additional file 8 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 8. TCGA top 1000 Gene Ontology. Gene Ontology enrichment for the top 1000 genes whose expression across TCGA cancer types is most positively correlated with cancer type mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120549
title: Additional file 9 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 9. TCGA bottom 1000 Gene Ontology. Gene Ontology enrichment for the bottom 1000 genes, whose expression across TCGA cancer types is most negatively correlated with cancer type mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120549.v1
title: Additional file 9 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 9. TCGA bottom 1000 Gene Ontology. Gene Ontology enrichment for the bottom 1000 genes, whose expression across TCGA cancer types is most negatively correlated with cancer type mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.6084/m9.figshare.17120540.v1
title: Additional file 8 of Malignancy and NF-κB signalling strengthen coordination between expression of mitochondrial and nuclear-encoded oxidative phosphorylation genes

description: Additional File 8. TCGA top 1000 Gene Ontology. Gene Ontology enrichment for the top 1000 genes whose expression across TCGA cancer types is most positively correlated with cancer type mtOXPHOS-nuOXPHOS correlation. Note the spreadsheet has multiple tabs corresponding to different gene set libraries interrogated.
DOI: 10.5281/zenodo.5750931
title: CAMSRA_Surface_O3S

description: This data is downloaded from CDS and it is produced by ECMWF with the name of CAMS global reanalysis (EAC4). Generated using Copernicus Climate Change Service information 2021 Neither the European Commission nor ECMWF is responsible for any use that may be made of the Copernicus information or data it contains.
DOI: 10.5281/zenodo.5750930
title: CAMSRA_Surface_O3S

description: This data is downloaded from CDS and it is produced by ECMWF with the name of CAMS global reanalysis (EAC4). Generated using Copernicus Climate Change Service information 2021 Neither the European Commission nor ECMWF is responsible for any use that may be made of the Copernicus information or data it contains.
DOI: 10.34740/kaggle/dsv/2880927
title: Covid-19 in Singapore : Latest Detailed Data
DOI: 10.34740/kaggle/dsv/2880935
title: Covid-19 in Singapore : Latest Detailed Data
DOI: 10.3886/e119446v133-103120
title: COVID-19 US State Policy Database

description: For questions or comments about the database please contact:<br>Alexandra Skinner <br>skinnera@bu.edu <br>Research Fellow & Database Manager<br>Department of Health Law, Policy & Management <br>Boston University School of Public Health<br><br>Database of state policies on closures, shelter-in-place orders, housing protections, changes to Medicaid and SNAP, physical distancing closures, reopening, and more created by researchers at the Boston University School of Public Health. Policies included are state-wide directives or mandates, not guidance or recommendations. In order for a policy to be included, it must apply to the entire state. We are working quickly to go through state government websites to make the policy database as complete and accurate as possible in a rapidly changing policy context. If you use data on a given policy, we encourage you to triangulate based on additional sources of policy data and to review the source documentation to consider the coding decisions that are right for your work. Of course, please email us if you note a discrepancy so we can improve the database for everyone. State policy source documentation can be found at: tinyurl.com/statepolicysources.
description: State policies. Smallest Geographic Unit: State
description: other; Contributors: Megan Cole Brahim, Noa Krawczyk, Carolyn Hoffman, Claire Corkish, Elizabeth Ferrara, Elizabeth Long, Emily Baroni, Faith Contador, Hannah Simon, Morgan Simko, Rachel Scheckman, Sarah Brewer, Sue Kulkarni, Felicia Heykoop, Manish Patel, Aishwarya Vidyasagaran, Andrew Chiao, Cara Safon, Samantha Burkhart, Harry Jung, Victor Lee, Marina MacKinnon, Aarohi Rede, Marie Vearling, Sophie Li, Christina Wang, Tim Levengood, María Jordán P. Emma Chistolini
DOI: 10.6084/m9.figshare.17119928.v1
title: Additional file 2 of Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)

description: Additional file 2: Supplementary Table 1. Repeated bivariate measure ANOVA of functional outcomes for sociodemographic characteristics by diagnostic groups. Significant p values bolded.
DOI: 10.25934/pr00003668.0
title: Available IPD datapackage for study 'A Phase III, Randomized, Double-blind, Parallel Group Study to Evaluate the Efficacy and Safety of Linagliptin 5 mg Compared to Placebo, Administered as Oral Fixed Dose Combination With Empagliflozin 10 mg or 25 mg for 24 Weeks, in Patients With Type 2 Diabetes Mellitus and Insufficient Glycaemic Control After 16 Weeks of Treatment With Empagliflozin 10 mg or 25 mg on Metformin Background Therapy'

description: The objective of the study is to investigate the efficacy, safety and tolerability of linagliptin 5 mg qd compared to placebo given for 24 weeks in inadequately controlled T2DM patients on empagliflozin 10 mg or 25 mg and maximum tolerated dose of metformin. The primary objective of efficacy evaluation is planned after 24 weeks of treatment. The study is designed to show superiority of the combination of empagliflozin and linagliptin over empagliflozin alone.
DOI: 10.6084/m9.figshare.17121074
title: Supplementary Material for: Prevention of Intra-Abdominal Adhesions Using the Combination of Mediclore® and a Statin

description: <b><i>Purpose:</i></b> This study investigated the antiadhesive effects of Mediclore®, rosuvastatin, and a combination of Mediclore and rosuvastatin in a rat adhesion model. <b><i>Methods:</i></b> The adhesion models (a total of 58 adult male rats) were divided into 4 groups. The control group (group C) received no special materials except for a saline. The experimental groups were treated with 5 mL of Mediclore (group M), rosuvastatin (group R), or rosuvastatin and Mediclore (group RM), and these materials were intraperitoneally placed under the incision. At postoperative day 14, the rats underwent re-laparotomy and adhesiolysis. Three investigators blinded to group assignment scored the extent of adhesion formation, the numbers of remote adhesions, and the extent of acute/chronic inflammation, fibrosis, edema, and congestion on resected specimens via histologic examination. <b><i>Results:</i></b> The macroscopic adhesion score in group RM (7.27 ± 3.51) was significantly lower than those in groups C (13.36 ± 2.24) and R (11.71 ± 1.98); group M (9.13 ± 4.09) had a significantly lower adhesion score than group C. The number of remote adhesions was significantly lower in groups R and RM than in group C. The acute inflammation score, chronic inflammation score, and fibrosis score in group RM; the acute inflammation score in group R; and the fibrosis score in group M were significantly lower than those in group C. <b><i>Conclusion:</i></b> The intraperitoneal application of Mediclore and a combination of Mediclore and rosuvastatin effectively reduced postoperative adhesions.
DOI: 10.6084/m9.figshare.17121074.v1
title: Supplementary Material for: Prevention of Intra-Abdominal Adhesions Using the Combination of Mediclore® and a Statin

description: <b><i>Purpose:</i></b> This study investigated the antiadhesive effects of Mediclore®, rosuvastatin, and a combination of Mediclore and rosuvastatin in a rat adhesion model. <b><i>Methods:</i></b> The adhesion models (a total of 58 adult male rats) were divided into 4 groups. The control group (group C) received no special materials except for a saline. The experimental groups were treated with 5 mL of Mediclore (group M), rosuvastatin (group R), or rosuvastatin and Mediclore (group RM), and these materials were intraperitoneally placed under the incision. At postoperative day 14, the rats underwent re-laparotomy and adhesiolysis. Three investigators blinded to group assignment scored the extent of adhesion formation, the numbers of remote adhesions, and the extent of acute/chronic inflammation, fibrosis, edema, and congestion on resected specimens via histologic examination. <b><i>Results:</i></b> The macroscopic adhesion score in group RM (7.27 ± 3.51) was significantly lower than those in groups C (13.36 ± 2.24) and R (11.71 ± 1.98); group M (9.13 ± 4.09) had a significantly lower adhesion score than group C. The number of remote adhesions was significantly lower in groups R and RM than in group C. The acute inflammation score, chronic inflammation score, and fibrosis score in group RM; the acute inflammation score in group R; and the fibrosis score in group M were significantly lower than those in group C. <b><i>Conclusion:</i></b> The intraperitoneal application of Mediclore and a combination of Mediclore and rosuvastatin effectively reduced postoperative adhesions.
DOI: 10.6084/m9.figshare.17121044
title: Supplementary Material for: Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids

description: Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulating MGHs have high motility and the interaction with the parasitoid rapidly triggers encapsulation. However, structural and molecular mechanisms behind these processes remained elusive. Here, we used detailed ultrastructural analysis and live cell imaging of MGHs to study encapsulation in <i>Drosophila ananassae</i> after parasitoid wasp infection. We found dynamic structural changes, mainly driven by the formation of diverse vesicular systems and newly developed complex intracytoplasmic membrane structures, and abundant generation of giant cell exosomes in MGHs. In addition, we used RNA sequencing to study the transcriptomic profile of MGHs and activated plasmatocytes 72 h after infection, as well as the uninduced blood cells. This revealed that differentiation of MGHs was accompanied by broad changes in gene expression. Consistent with the observed structural changes, transcripts related to vesicular function, cytoskeletal organization, and adhesion were enriched in MGHs. In addition, several orphan genes encoding for hemolysin-like proteins, pore-forming toxins of prokaryotic origin, were expressed at high level, which may be important for parasitoid elimination. Our results reveal coordinated molecular and structural changes in the course of MGH differentiation and parasitoid encapsulation, providing a mechanistic model for a powerful innate immune response.
DOI: 10.6084/m9.figshare.17121044.v1
title: Supplementary Material for: Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids

description: Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulating MGHs have high motility and the interaction with the parasitoid rapidly triggers encapsulation. However, structural and molecular mechanisms behind these processes remained elusive. Here, we used detailed ultrastructural analysis and live cell imaging of MGHs to study encapsulation in <i>Drosophila ananassae</i> after parasitoid wasp infection. We found dynamic structural changes, mainly driven by the formation of diverse vesicular systems and newly developed complex intracytoplasmic membrane structures, and abundant generation of giant cell exosomes in MGHs. In addition, we used RNA sequencing to study the transcriptomic profile of MGHs and activated plasmatocytes 72 h after infection, as well as the uninduced blood cells. This revealed that differentiation of MGHs was accompanied by broad changes in gene expression. Consistent with the observed structural changes, transcripts related to vesicular function, cytoskeletal organization, and adhesion were enriched in MGHs. In addition, several orphan genes encoding for hemolysin-like proteins, pore-forming toxins of prokaryotic origin, were expressed at high level, which may be important for parasitoid elimination. Our results reveal coordinated molecular and structural changes in the course of MGH differentiation and parasitoid encapsulation, providing a mechanistic model for a powerful innate immune response.
DOI: 10.6084/m9.figshare.17030138
title: Transaction Records

description: Records
DOI: 10.6084/m9.figshare.17030138.v6
title: Transaction Records

description: Records
DOI: 10.6084/m9.figshare.17030138.v5
title: Transaction Records

description: Records
DOI: 10.15151/esrf-es-637864432
title: Cryo-em of photosystem II (PSII) complexes

description: We try to perform high resolution structural studies of TSP4 PSII.
DOI: 10.6084/m9.figshare.16866292
title: Supplementary Material for: Molecular detection of parvovirus in Manchurian chipmunks (Tamias sibiricus asiaticus) captured in Korea

description: Cross-species transmission of viral diseases alarms our global community for its potential of novel pandemic events. Of various viral pathogens noted recently, parvoviruses have posed public health threats not only to humans but to wild animals. To investigate the prevalence of parvoviruses in wild Manchurian chipmunks, here we detected genetic fragments of the nonstructural protein of parvovirus by polymerase chain reaction in wild Manchurian chipmunk specimens captured in the central and southern regions of South Korea and compared their sequence homology with references. Of a total of 348 specimens examined, chipmunk parvovirus (ChpPV)-specific gene fragments were detected with a 31.32 % rate (109 chipmunks of 348) in their kidney, liver, lung, and spleen samples, and the chipmunks captured in Gangwon Province exhibited the highest positive rate (45.37%), followed by Gyeongsang (35.29%), Gyeonggi (31.03%), Chungcheong (20.00%), and Jeolla (19.70%). When compared with the reference sequences registered in GenBank, a partial ChpPV sequence showed 97.70% identity to the previously reported Korean strain at the nucleic acid level. In the phylogenetic analysis, ChpPV exhibited closer relationship to primate parvoviruses, erythroviruses, and bovine parvovirus than to adeno-associated viruses. Despite limited sample size and genetic sequences examined in this study, our results underline the prevalence of ChpPV in Korea and emphasize the need of close surveillance of parvoviruses in wild animals.
DOI: 10.6084/m9.figshare.17121080
title: Dataset for the manuscript entitled "Adaptation and psychometric evaluation of Hungarian version of the Fear of COVID-19 Scale"

description: Dataset for the manuscript entitled "Adaptation and psychometric evaluation of Hungarian version of the Fear of COVID-19 Scale"
DOI: 10.6084/m9.figshare.17121113
title: Supplementary Material for: Gender-Specific Differences of Renal Heat Tolerance in Older Adults during Heat Waves

description: <b><i>Background:</i></b> Heat waves are known to cause increased morbidity and mortality in susceptible populations like old and functionally impaired people. The objective of the study was to assess renal tubular stress, a predictor for development of acute kidney injury, during heat waves in Central Europe. As a marker of renal tubular stress tissue inhibitor of metalloproteinases-2 [TIMP-2]·insulin-like growth factor binding protein-7 [IGFBP7], a new FDA-cleared renal tubular stress biomarker, was used. <b><i>Materials and Methods:</i></b> 68 residents from facilities of sheltered housing with urine samples collected at heat waves in 2015 and at control visits were included. Urinary [TIMP-2]·[IGFBP7] was compared between the heat waves and the control visits. Multivariate linear models were adjusted for age, frailty index, and functional comorbidity index. <b><i>Results:</i></b> The median age was 82.0 years, 82.3% were women. The percentage of elevated levels of urinary [TIMP-2]·[IGFBP7] (&gt;0.3 [ng/mL]<sup>2</sup>/1,000) in the total study population was higher at the heat waves than at the control visits (25.0% vs. 17.7%). The effect of the heat waves on urinary [TIMP-2]·[IGFBP7] was stronger in men than in women: The percentage of elevated levels was 75.0% in men and 14.3% in women. In the multivariate analysis, the mean urinary [TIMP-2]·[IGFBP7] was 0.48 (95% CI 0.25; 0.70) (ng/mL)<sup>2</sup>/1,000 higher in men than in women. Except gender, a number of additional variables did not show an association with urinary [TIMP-2]·[IGFBP7] at the heat waves or the control visits. <b><i>Conclusions:</i></b> At heat waves, urinary [TIMP-2]·[IGFBP7] was elevated and higher in men than in women. This suggests gender-specific differences in renal heat tolerance in older people.
DOI: 10.6084/m9.figshare.17121113.v1
title: Supplementary Material for: Gender-Specific Differences of Renal Heat Tolerance in Older Adults during Heat Waves

description: <b><i>Background:</i></b> Heat waves are known to cause increased morbidity and mortality in susceptible populations like old and functionally impaired people. The objective of the study was to assess renal tubular stress, a predictor for development of acute kidney injury, during heat waves in Central Europe. As a marker of renal tubular stress tissue inhibitor of metalloproteinases-2 [TIMP-2]·insulin-like growth factor binding protein-7 [IGFBP7], a new FDA-cleared renal tubular stress biomarker, was used. <b><i>Materials and Methods:</i></b> 68 residents from facilities of sheltered housing with urine samples collected at heat waves in 2015 and at control visits were included. Urinary [TIMP-2]·[IGFBP7] was compared between the heat waves and the control visits. Multivariate linear models were adjusted for age, frailty index, and functional comorbidity index. <b><i>Results:</i></b> The median age was 82.0 years, 82.3% were women. The percentage of elevated levels of urinary [TIMP-2]·[IGFBP7] (&gt;0.3 [ng/mL]<sup>2</sup>/1,000) in the total study population was higher at the heat waves than at the control visits (25.0% vs. 17.7%). The effect of the heat waves on urinary [TIMP-2]·[IGFBP7] was stronger in men than in women: The percentage of elevated levels was 75.0% in men and 14.3% in women. In the multivariate analysis, the mean urinary [TIMP-2]·[IGFBP7] was 0.48 (95% CI 0.25; 0.70) (ng/mL)<sup>2</sup>/1,000 higher in men than in women. Except gender, a number of additional variables did not show an association with urinary [TIMP-2]·[IGFBP7] at the heat waves or the control visits. <b><i>Conclusions:</i></b> At heat waves, urinary [TIMP-2]·[IGFBP7] was elevated and higher in men than in women. This suggests gender-specific differences in renal heat tolerance in older people.
DOI: 10.6084/m9.figshare.17121104
title: Supplementary Material for: High Prevalence and Early Onsets: Legal and Illegal Substance Use in an Urban Cohort of Young Adults in Switzerland

description: <b><i>Introduction:</i></b> Debates about the legalization of illegal substances (e.g., cannabis) continue around the globe. A key consideration in these debates is the adequate protection of young people, which could be informed by current prevalence and age-of-onset patterns. For Switzerland, such information is limited, which is particularly true for women, despite advanced political efforts to legalize cannabis. The objective of the current study was to investigate substance use prevalence rates and ages of onset in a community-representative sample of female and male young adults in Switzerland. <b><i>Methods:</i></b> Data came from the Zurich Project on the Social Development from Childhood to Adulthood (z-proso). In 2018, participants (<i>N</i> = 1,180, 50.8% females) were ∼20 years old. Lifetime and past-year use of alcohol, tobacco, cannabinoids, stimulants, hallucinogens, opioids, and benzodiazepines were assessed with an extensive substance use questionnaire. Additionally, ages of onsets of the respective substances were estimated by averaging participants’ self-reported ages of onsets from ages 13 to 20 (max. 4 assessments). <b><i>Results:</i></b> 57% of 20-year-olds had used cannabinoids, 16% stimulants, 15% opioids (mostly codeine), and 8% hallucinogens in the past year. Males had higher prevalence than females for most drugs; nevertheless, females’ prevalence rates were notably high. Legal substance use was typically initiated 1.3–2.7 years before legal selling age. Thus, almost half of the sample had consumed alcohol and tobacco by age 14. More than 40% of the total sample had smoked cannabis by age 16. Males initiated use of legal substances and cannabis earlier than females. <b><i>Discussion:</i></b> Our recent community-representative data suggested unexpectedly high levels and early onsets of substance use compared to a previous Swiss surveys and also the European average. Drug policy debates should consider urban substance use patterns when considering legalization efforts.