cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7064417
title: Predicting microRNA-disease associations using bipartite local models and hubness-aware regression

description: The development and progression of numerous complex human diseases have been confirmed to be associated with microRNAs (miRNAs) by various experimental and clinical studies. Predicting potential miRNA-disease associations can help us understand the underlying molecular and cellular mechanisms of diseases and promote the development of disease treatment and diagnosis. Due to the high cost of conventional experimental verification, proposing a new computational method for miRNA-disease association prediction is an efficient and economical way. Since previous computational models ignored the hubness phenomenon, we presented a novel computational model of Bipartite Local models and Hubness-Aware Regression for MiRNA-Disease Association prediction (BLHARMDA). In this method, we first used known miRNA-disease associations to calculate the Jaccard similarity between miRNAs and between diseases, then utilized a modified kNNs model in the bipartite local model method. As a result, we effectively alleviated the detriments from ‘bad’ hubs. BLHARMDA obtained AUCs of 0.9141 and 0.8390 in the global and local leave-one-out cross validation, respectively, which outperformed most of the previous models and proved high prediction performance of BLHARMDA. Besides, the standard deviation of 0.0006 in 5-fold cross validation confirmed our model’s prediction stability and the averaged prediction accuracy of 0.9120 showed the high precision of our model. In addition, to further evaluate our model’s accuracy, we implemented BLHARMDA on three typical human diseases in three different types of case studies. As a result, 49 (Esophageal Neoplasms), 50 (Lung Neoplasms) and 50 (Carcinoma Hepatocellular) out of the top 50 related miRNAs were validated by recent experimental discoveries.
DOI: 10.6084/m9.figshare.7064417.v1
title: Predicting microRNA-disease associations using bipartite local models and hubness-aware regression

description: The development and progression of numerous complex human diseases have been confirmed to be associated with microRNAs (miRNAs) by various experimental and clinical studies. Predicting potential miRNA-disease associations can help us understand the underlying molecular and cellular mechanisms of diseases and promote the development of disease treatment and diagnosis. Due to the high cost of conventional experimental verification, proposing a new computational method for miRNA-disease association prediction is an efficient and economical way. Since previous computational models ignored the hubness phenomenon, we presented a novel computational model of Bipartite Local models and Hubness-Aware Regression for MiRNA-Disease Association prediction (BLHARMDA). In this method, we first used known miRNA-disease associations to calculate the Jaccard similarity between miRNAs and between diseases, then utilized a modified kNNs model in the bipartite local model method. As a result, we effectively alleviated the detriments from ‘bad’ hubs. BLHARMDA obtained AUCs of 0.9141 and 0.8390 in the global and local leave-one-out cross validation, respectively, which outperformed most of the previous models and proved high prediction performance of BLHARMDA. Besides, the standard deviation of 0.0006 in 5-fold cross validation confirmed our model’s prediction stability and the averaged prediction accuracy of 0.9120 showed the high precision of our model. In addition, to further evaluate our model’s accuracy, we implemented BLHARMDA on three typical human diseases in three different types of case studies. As a result, 49 (Esophageal Neoplasms), 50 (Lung Neoplasms) and 50 (Carcinoma Hepatocellular) out of the top 50 related miRNAs were validated by recent experimental discoveries.
DOI: 10.6084/m9.figshare.16305607
title: Additional file 9 of Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

description: Additional file 9: Table 3. Distribution of the 52 genes in meQTLs by each causal model.
DOI: 10.6084/m9.figshare.7064504
title: Semi-quantitative method for task planning in product eco-design

description: Ensuring the environmental sustainability of products is challenging because it involves all the stages and processes throughout product life cycle. Product eco-design is essential to achieve it. In the proposed methodology, product eco-design is implemented based on five eco-design elements, namely, function, material, geometric structure, connection relationship and manufacturing process. However, because of the fragmentation of existing eco-design tools, the gap between eco-design evaluation and eco-design optimisation requires a new mechanism to seamlessly integrate them for efficient industrial applications. A new checklist tool called Checklist of Product Eco-design Optimisation Potential (CPEOP) is developed to assess product eco-design optimisation potential. Based on the new tool, optimisation effect of product eco-design can be quantitatively assessed. Furthermore, a novel semi-quantitative method for task planning in product eco-design is proposed, which involves evaluating the product with CPEOP, screening candidates for eco-design and determining the candidates’ optimisation directions. The uncertainties arising from CPEOP and enterprise design status quo are further analysed. Subsequently, a case study on a refrigerator is conducted to elucidate the process of the method and reveal its potential. The proposed method is then discussed through a comparison with two mainstream eco-design tools.
DOI: 10.6084/m9.figshare.7064504.v1
title: Semi-quantitative method for task planning in product eco-design

description: Ensuring the environmental sustainability of products is challenging because it involves all the stages and processes throughout product life cycle. Product eco-design is essential to achieve it. In the proposed methodology, product eco-design is implemented based on five eco-design elements, namely, function, material, geometric structure, connection relationship and manufacturing process. However, because of the fragmentation of existing eco-design tools, the gap between eco-design evaluation and eco-design optimisation requires a new mechanism to seamlessly integrate them for efficient industrial applications. A new checklist tool called Checklist of Product Eco-design Optimisation Potential (CPEOP) is developed to assess product eco-design optimisation potential. Based on the new tool, optimisation effect of product eco-design can be quantitatively assessed. Furthermore, a novel semi-quantitative method for task planning in product eco-design is proposed, which involves evaluating the product with CPEOP, screening candidates for eco-design and determining the candidates’ optimisation directions. The uncertainties arising from CPEOP and enterprise design status quo are further analysed. Subsequently, a case study on a refrigerator is conducted to elucidate the process of the method and reveal its potential. The proposed method is then discussed through a comparison with two mainstream eco-design tools.
DOI: 10.6084/m9.figshare.16305607.v1
title: Additional file 9 of Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

description: Additional file 9: Table 3. Distribution of the 52 genes in meQTLs by each causal model.
DOI: 10.6084/m9.figshare.21220196.v1
title: Additional file 2 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 2.
DOI: 10.6084/m9.figshare.21220205.v1
title: Additional file 5 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 5.
DOI: 10.6084/m9.figshare.21220202.v1
title: Additional file 4 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 4.
DOI: 10.6084/m9.figshare.21220208.v1
title: Additional file 6 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 6.
DOI: 10.6084/m9.figshare.21220199
title: Additional file 3 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 3.
DOI: 10.6084/m9.figshare.21220205
title: Additional file 5 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 5.
DOI: 10.6084/m9.figshare.21220196
title: Additional file 2 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 2.
DOI: 10.6084/m9.figshare.21220208
title: Additional file 6 of Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet

description: Additional file 6.
DOI: 10.6084/m9.figshare.6318431
title: The concept of cooking skills: A review with contributions to the scientific debate

description: ABSTRACT This paper aimed to conduct a literature review about the concept of cooking skills to contribute to the scientific debate about the subject. A systematic search was performed in the Scopus, PubMed/MedLine and Web of Science databases as well as the periodicals of the Federal Agency for Support and Evaluation of Graduate Education in Brazil Coordenação de Aperfeiçoamento de Pessoal de Nível Superior website, using the following Portuguese and English keywords: cooking skills, cooking and food/meal preparation. We also consulted references cited by these papers, electronic dictionaries (in Portuguese, English and French), technical documents found on public and private institutional websites, as well as books. Basic, etymological/vernacular and systematic definitions for cooking were identified, including historical global and national contexts. To conceptualize cooking skills, categories related to food and individuals were established, purposing a conceptual model. The category related to food referred to the use of unprocessed/minimal processed foods (which require procedures prior to their preparation), and/or processed/ultra-processed foods (which need a little or no preparation, such as re-heating). The category related to individuals involved dimensions such as confidence, attitudes, behavior, and individual knowledge used to prepare foods. The historical definitions of cooking allowed us to clarify the concept of cooking skills. Considering the global context of valuing and recovering cooking for the promotion of healthy eating, this review can contribute to the scientific discussion about the concept of cooking skills. The purposed conceptual model enables parameters to be established for further investigations, allowing cooking interventions to be directed toward promoting healthy eating.
DOI: 10.6084/m9.figshare.6318431.v1
title: The concept of cooking skills: A review with contributions to the scientific debate

description: ABSTRACT This paper aimed to conduct a literature review about the concept of cooking skills to contribute to the scientific debate about the subject. A systematic search was performed in the Scopus, PubMed/MedLine and Web of Science databases as well as the periodicals of the Federal Agency for Support and Evaluation of Graduate Education in Brazil Coordenação de Aperfeiçoamento de Pessoal de Nível Superior website, using the following Portuguese and English keywords: cooking skills, cooking and food/meal preparation. We also consulted references cited by these papers, electronic dictionaries (in Portuguese, English and French), technical documents found on public and private institutional websites, as well as books. Basic, etymological/vernacular and systematic definitions for cooking were identified, including historical global and national contexts. To conceptualize cooking skills, categories related to food and individuals were established, purposing a conceptual model. The category related to food referred to the use of unprocessed/minimal processed foods (which require procedures prior to their preparation), and/or processed/ultra-processed foods (which need a little or no preparation, such as re-heating). The category related to individuals involved dimensions such as confidence, attitudes, behavior, and individual knowledge used to prepare foods. The historical definitions of cooking allowed us to clarify the concept of cooking skills. Considering the global context of valuing and recovering cooking for the promotion of healthy eating, this review can contribute to the scientific discussion about the concept of cooking skills. The purposed conceptual model enables parameters to be established for further investigations, allowing cooking interventions to be directed toward promoting healthy eating.
DOI: 10.6084/m9.figshare.6504350
title: Predictive capacity of indicators of adiposity in the metabolic syndrome in elderly individuals

description: ABSTRACT Objective To evaluate the predictive ability of adiposity indicators as MetS predictors in elderly individuals. Methods Cross-sectional study enrolled in the Estratégia Saúde da Família (Family Health Strategy). Anthropometric measurements were measured. Body Mass Index, Waist-Hip Ratio, Waist-Height Ratio, Conicity Index and Body Adiposity Index were calculated. Blood was collected and resting blood pressure was measured. MetS was classified according to the harmonizing criteria. The predictive ability of anthropometric variables was evaluated using Receiver Operating Characteristic curves. Results Regarding male individuals, our research indicates that the BMI, Waist-Height Ratio and Waist Hip Ratio are better predictors and they are equivalent to each other. As for female individuals, results show that the Body Mass Index and Waist-Height Ratio are better predictors and equivalent to each other. Conclusion Waist-Height Ratio and Body Mass Index are good MetS predictors for elderly individuals, especially among men. More research in this area is important. Comitê de Ética em Pesquisa com Seres Humanos da Universidade Federal de Viçosa. (Viçosa University Ethics Committee in Research with Human Beings) (nº 039/2011).
DOI: 10.6084/m9.figshare.6504350.v1
title: Predictive capacity of indicators of adiposity in the metabolic syndrome in elderly individuals

description: ABSTRACT Objective To evaluate the predictive ability of adiposity indicators as MetS predictors in elderly individuals. Methods Cross-sectional study enrolled in the Estratégia Saúde da Família (Family Health Strategy). Anthropometric measurements were measured. Body Mass Index, Waist-Hip Ratio, Waist-Height Ratio, Conicity Index and Body Adiposity Index were calculated. Blood was collected and resting blood pressure was measured. MetS was classified according to the harmonizing criteria. The predictive ability of anthropometric variables was evaluated using Receiver Operating Characteristic curves. Results Regarding male individuals, our research indicates that the BMI, Waist-Height Ratio and Waist Hip Ratio are better predictors and they are equivalent to each other. As for female individuals, results show that the Body Mass Index and Waist-Height Ratio are better predictors and equivalent to each other. Conclusion Waist-Height Ratio and Body Mass Index are good MetS predictors for elderly individuals, especially among men. More research in this area is important. Comitê de Ética em Pesquisa com Seres Humanos da Universidade Federal de Viçosa. (Viçosa University Ethics Committee in Research with Human Beings) (nº 039/2011).
DOI: 10.6084/m9.figshare.6504257
title: The under-reporting of energy intake influences the dietary pattern reported by obese women in the waiting list for bariatric surgery

description: ABSTRACT Objective To verify the interference of the energy intake under-reporting in the determination of the dietary patterns and nutrient intakes reported by obese women in the waiting list for bariatric surgery. Methods The study included 412 women aged 20 to 45 years with a body mass index ranging from 35 to 60kg/m2 who were on waiting list for bariatric surgery. Data from three reported food intake and physical activity, body weight, and height were used for estimating the reported energy intake, physical activity level, and resting energy expenditure. Subsequently, it was checked the biological plausibility of the reported energy intakes, classifying all participants as plausible reporters or under-reporters. Exploratory factor analysis was used to determine the participants’ dietary patterns. The Mann-Whitney test assessed the reported energy and nutrient intakes between plausible reporters and under-reporters groups. The Z-test assessed the variables of plausible reporters or under-reporters in relation to all participants of the study. Results Six dietary patterns were determined for all participants of study. After excluding information from under-reporting women, only two dietary patterns remained similar to those of all participants, while three other dietary patterns presented different conformations from food subgroups to plausible reporters. The reported energy intake did not present difference for the subgroups of fruits, leaf vegetables and vegetables. However, the energetic value reported for the other food subgroups was higher for the plausible reporters. Conclusion The under-reporting of energy intake influenced the determination of dietary patterns of obese women waiting for bariatric surgery.
DOI: 10.6084/m9.figshare.7562729
title: Markers of healthy eating habits, water intake, and constipation in children between 4 and 7 years of age

description: ABSTRACT Objective To evaluate the association between diet and constipation in children between four and seven years of age. Methods A cross-sectional study with 152 children between 4 and 7 years of age residing in Viçosa, Brazil. Constipation was defined in accordance with the Rome IV diagnostic criteria. Dietary habits were evaluated based on the frequency of food intake using a food diary for three days. Dietary analysis considered foods deemed healthy and unhealthy which could be associated with constipation, as well as the children’s consumption of fruits and vegetables. The amounts of fiber and water consumed were also rated as adequate or inadequate. As part of the analyses, Student’s t-test and the chi-square test were performed with a significance level of p&lt;0.05. Results The prevalence of constipation was 32.2%. Constipation was more common among children who did not consume fruits (p=0.020) or greens (p=0.002), as well as among children who consumed “instant” chocolate drinks (p=0.033). An association was found between the frequent consumption of fried food (p=0.020), a daily water intake lower than 600mL, and constipation (p=0.028). Conclusion Unhealthy eating habits among children, such as the lack of fruit and greens intake and the consumption of “instant” chocolate drinks and fried foods, were found to be positively correlated with constipation. The low fruit and vegetable consumption observed herein reflects the need for changes in children’s eating habits and the implementation of measures to promote the intake of healthy foods.
DOI: 10.6084/m9.figshare.7562729.v1
title: Markers of healthy eating habits, water intake, and constipation in children between 4 and 7 years of age

description: ABSTRACT Objective To evaluate the association between diet and constipation in children between four and seven years of age. Methods A cross-sectional study with 152 children between 4 and 7 years of age residing in Viçosa, Brazil. Constipation was defined in accordance with the Rome IV diagnostic criteria. Dietary habits were evaluated based on the frequency of food intake using a food diary for three days. Dietary analysis considered foods deemed healthy and unhealthy which could be associated with constipation, as well as the children’s consumption of fruits and vegetables. The amounts of fiber and water consumed were also rated as adequate or inadequate. As part of the analyses, Student’s t-test and the chi-square test were performed with a significance level of p&lt;0.05. Results The prevalence of constipation was 32.2%. Constipation was more common among children who did not consume fruits (p=0.020) or greens (p=0.002), as well as among children who consumed “instant” chocolate drinks (p=0.033). An association was found between the frequent consumption of fried food (p=0.020), a daily water intake lower than 600mL, and constipation (p=0.028). Conclusion Unhealthy eating habits among children, such as the lack of fruit and greens intake and the consumption of “instant” chocolate drinks and fried foods, were found to be positively correlated with constipation. The low fruit and vegetable consumption observed herein reflects the need for changes in children’s eating habits and the implementation of measures to promote the intake of healthy foods.
DOI: 10.6084/m9.figshare.14320649
title: Birth weight, physical growth and body composition in children: A longitudinal study

description: ABSTRACT Objective To describe children’s physical growth (body mass and height) velocity and body composition (fat percentage and Fat Free Mass); to investigate the magnitude of interindividual differences according to age, gender and birth weight categories, as well as to examine the differences in the average trajectories of children with Low Birth Weight and Normal Weight according to international references. Methods The sample consisted of 534 children (279 boys and 255 girls, 7 to 10 years old) evaluated in the first year of study and followed for 3 years with overlap between the ages of 7 and 9 years. Physical growth and body composition measurements included: height, body mass, fat percentage (�t) and Fat Free Mass. Multilevel Modelling was used. Results Birth weight was not associated with physical growth and body composition markers at 7 years old or with the velocity of their changes (p&gt;0.05). There were significant interindividual differences in the trajectories of physical growth (height and body mass; p&lt;0.001) and body composition (�t and Fat Free Mass; p&lt;0.001). In plotting on international percentile charts, the trajectories of growth and body composition were within expected values for age and gender, regardless of birth weight. Conclusion There are significant differences in the dynamics of stature growth, body mass and Fat Free Mass, and Low Birth Weight has no influence on this trajectory. In addition, values are within the expected range for age and sex.