cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/126337
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE16-10 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124459
title: Barometer data collected during research cruise PE16-10 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352774
title: RNA Seq report.tar.bz2

description: RNA-seq data for the following project: A high-throughput anti-aging drug screen was developed that simultaneously measures senescence-associated b-galactosidase activity and proliferation. Applied to replicatively pre-aged fibroblasts, this screen yielded violuric acid (VA) and 1-naphthoquinone-2-monoxime (N2N1) as its top two hits. These lead compounds extended the replicative life spans of normal and progeroid human cells in a dose-dependent manner and also extended the chronological life spans of mice and C. elegans. They are further shown here to function as redox catalysts in oxidations of NAD(P)H. They thus slow age-related declines in NAD(P)<sup>+</sup>/NAD(P)H ratios. VA participates in non-enzymatic electron transfers from NAD(P)H to oxidized glutathione or peroxides. N2N1 transfers electrons from NAD(P)H to cytochrome c or CoQ<sub>10</sub> via NAD(P)H dehydrogenase (quinone) 1 (NQO1). Our results indicate that pharmacologic manipulation of NQO1 activity <i>via</i> redox catalysts may reveal mechanisms of senescence and aging
DOI: 10.7284/124589
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-10 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352774.v1
title: RNA Seq report.tar.bz2

description: RNA-seq data for the following project: A high-throughput anti-aging drug screen was developed that simultaneously measures senescence-associated b-galactosidase activity and proliferation. Applied to replicatively pre-aged fibroblasts, this screen yielded violuric acid (VA) and 1-naphthoquinone-2-monoxime (N2N1) as its top two hits. These lead compounds extended the replicative life spans of normal and progeroid human cells in a dose-dependent manner and also extended the chronological life spans of mice and C. elegans. They are further shown here to function as redox catalysts in oxidations of NAD(P)H. They thus slow age-related declines in NAD(P)<sup>+</sup>/NAD(P)H ratios. VA participates in non-enzymatic electron transfers from NAD(P)H to oxidized glutathione or peroxides. N2N1 transfers electrons from NAD(P)H to cytochrome c or CoQ<sub>10</sub> via NAD(P)H dehydrogenase (quinone) 1 (NQO1). Our results indicate that pharmacologic manipulation of NQO1 activity <i>via</i> redox catalysts may reveal mechanisms of senescence and aging
DOI: 10.7284/124463
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-10 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124460
title: Hygrometer data collected during research cruise PE16-10 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.21954/ou.rd.7352579
title: OpenMARS MY28-32 standard database

description: The Open access to Mars Assimilated Remote Soundings (OpenMARS) database is a reanalysis product combining past spacecraft observations with a state-of-the-art Mars Global Circulation Model (GCM). The OpenMARS product is a global surface/atmosphere reference database of key variables for multiple Mars years.<br><br>Spacecraft observations of column dust optical depth and temperature profiles from the Mars Climate Sounder (MCS) instrument on the Mars Reconnaissance Orbiter spacecraft are combined with a Mars GCM used at the Open University. The standard database includes 2-hourly output of key dynamic and surface variables such as zonal/meridional wind, temperature as a function of altitude and column dust optical depth.<br>Extended details on this dataset can be found in the OpenMARS-MY28-32-reference-manual.pdf document included in this repository.<br>This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633127.
DOI: 10.21954/ou.rd.7352579.v1
title: OpenMARS MY28-32 standard database

description: The Open access to Mars Assimilated Remote Soundings (OpenMARS) database is a reanalysis product combining past spacecraft observations with a state-of-the-art Mars Global Circulation Model (GCM). The OpenMARS product is a global surface/atmosphere reference database of key variables for multiple Mars years.<br><br>Spacecraft observations of column dust optical depth and temperature profiles from the Mars Climate Sounder (MCS) instrument on the Mars Reconnaissance Orbiter spacecraft are combined with a Mars GCM used at the Open University. The standard database includes 2-hourly output of key dynamic and surface variables such as zonal/meridional wind, temperature as a function of altitude and column dust optical depth.<br>Extended details on this dataset can be found in the OpenMARS-MY28-32-reference-manual.pdf document included in this repository.<br>This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633127.
DOI: 10.7284/124461
title: Transmissometer data collected during research cruise PE16-10 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352471
title: Quantitative evaluation of the relative apparent diffusion coefficient values on multiparametric magnetic resonance imaging to predict higher Gleason score prostate cancer

description: <b>Introduction</b>: Apparent diffusion coefficient (ADC) values on multiparametric magnetic resonance imaging (mpMRI) have been reported to correlate with high-Gleason score (GS) prostate cancer. However, the relative ADC values between tumor lesions and normal tissue have been suggested as more suitable than the absolute ADC values for evaluation of diffusion abnormalities, because absolute ADC values are susceptible to differences in scanners or scanner settings. The present study evaluated the usefulness of the relative assessment of ADC values between tumor lesions and normal tissue on preoperative mpMRI for the prediction of high-risk prostate cancer on radical prostatectomy specimens. <b>Materials and Methods</b>: A retrospective analysis of 48 men who underwent radical prostatectomy between January 2013 and December 2014 was conducted. MpMRI was performed with a 3.0-T scanner using b-values of 0 and 1500 s/mm<sup>2</sup>. ADC values of the tumor (ADC<sub>TUMOR</sub>) and normal prostate and the relative ADC tumor/normal ratio (ADC<sub>TNR</sub>) were evaluated by two radiologists. <b>Results</b>: The inter-rater reliability between two radiologists for ADC<sub>TUMOR</sub> measurement was high, with Pearson’s <i>r</i> = 0.982. There was no difference in ADC<sub>TUMOR</sub> between GS ≤7 and GS ≥8. In contrast, ADC<sub>TNR</sub> was significantly lower in GS ≥8 than in GS ≤7. ROC curves of ADC<sub>TNR</sub> to predict higher GS (≥8) showed better classification performance (AUC = 0.8243, <i>p</i> = .0012 by radiologist A and AUC = 0.7961, <i>p</i> = .0031 by radiologist B) than of ADC<sub>TUMOR</sub>. <b>Conclusions</b>: The relative assessment of ADC values between tumor lesions and normal tissue could improve the detection rate of high-risk prostate cancers.
DOI: 10.7284/124462
title: TSG (Thermosalinograph) data collected during research cruise PE16-10 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352471.v1
title: Quantitative evaluation of the relative apparent diffusion coefficient values on multiparametric magnetic resonance imaging to predict higher Gleason score prostate cancer

description: <b>Introduction</b>: Apparent diffusion coefficient (ADC) values on multiparametric magnetic resonance imaging (mpMRI) have been reported to correlate with high-Gleason score (GS) prostate cancer. However, the relative ADC values between tumor lesions and normal tissue have been suggested as more suitable than the absolute ADC values for evaluation of diffusion abnormalities, because absolute ADC values are susceptible to differences in scanners or scanner settings. The present study evaluated the usefulness of the relative assessment of ADC values between tumor lesions and normal tissue on preoperative mpMRI for the prediction of high-risk prostate cancer on radical prostatectomy specimens. <b>Materials and Methods</b>: A retrospective analysis of 48 men who underwent radical prostatectomy between January 2013 and December 2014 was conducted. MpMRI was performed with a 3.0-T scanner using b-values of 0 and 1500 s/mm<sup>2</sup>. ADC values of the tumor (ADC<sub>TUMOR</sub>) and normal prostate and the relative ADC tumor/normal ratio (ADC<sub>TNR</sub>) were evaluated by two radiologists. <b>Results</b>: The inter-rater reliability between two radiologists for ADC<sub>TUMOR</sub> measurement was high, with Pearson’s <i>r</i> = 0.982. There was no difference in ADC<sub>TUMOR</sub> between GS ≤7 and GS ≥8. In contrast, ADC<sub>TNR</sub> was significantly lower in GS ≥8 than in GS ≤7. ROC curves of ADC<sub>TNR</sub> to predict higher GS (≥8) showed better classification performance (AUC = 0.8243, <i>p</i> = .0012 by radiologist A and AUC = 0.7961, <i>p</i> = .0031 by radiologist B) than of ADC<sub>TUMOR</sub>. <b>Conclusions</b>: The relative assessment of ADC values between tumor lesions and normal tissue could improve the detection rate of high-risk prostate cancers.
DOI: 10.6084/m9.figshare.7352468
title: Measles virus genome

description: A generic MeV genome representation highlighting coding sequences, proteins produced (yellow boxes) and the diagnostic and sequencing PCR assay target regions referred to in the linked bioRxiv manuscript. The genome is drawn to scale based on MeV Edmonston strain (GenBank accession: AF266288).<b></b>
DOI: 10.7284/124468
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-11 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352489.v2
title: Queensland Measles virus (MeV) genotypes, 2010 to 2017

description: Phylogenetic analysis of partial nucleoprotein (N)-gene sequences from 122 MeV positive clinical specimens analysed in Queensland between 2010 and 2017. The sequenced region includes the World Health Organization-recommended N450 amplicon encoding the carboxyl-terminal of the N gene. MeV sequences associated with sequenced patients are marked in red, MeVV strain sequences in blue and WHO reference sequences, used to define genotypes and subtypes are marked in green.<br>
DOI: 10.7284/124478
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-12 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124483
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-13 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352468.v3
title: Measles virus genome

description: A generic MeV genome representation highlighting coding sequences, proteins produced (yellow boxes) and the diagnostic and sequencing PCR assay target regions referred to in the linked bioRxiv manuscript. The genome is drawn to scale based on MeV Edmonston strain (GenBank accession: AF266288).<b></b>
DOI: 10.7284/124488
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-14 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352462
title: Appendix 2: Geochemical data. Timing of strain partitioning and magmatism in the Scottish Scandian collision, evidence from the high Ba–Sr Orkney granite complex

description: Appendix 2: Geochemical data
DOI: 10.6084/m9.figshare.7352462.v1
title: Appendix 2: Geochemical data. Timing of strain partitioning and magmatism in the Scottish Scandian collision, evidence from the high Ba–Sr Orkney granite complex

description: Appendix 2: Geochemical data
DOI: 10.6084/m9.figshare.7352465
title: Appendix 1: Geochronological data. Timing of strain partitioning and magmatism in the Scottish Scandian collision, evidence from the high Ba–Sr Orkney granite complex

description: Appendix 1: Geochronological data
DOI: 10.7284/124492
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-15 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352441
title: Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm

description: All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the fungicide vinclozolin (VIN) perturb hormone signaling and lead to dysfunctions following prenatal exposures. Beyond direct exposures, transgenerational disease phenotypes can persist for multiple generations without subsequent exposure. The mechanisms of action of these EDCs differ: VIN is anti-androgenic while the PCB mixture Aroclor 1221 (A1221) is weakly estrogenic. Based on limited evidence for the inheritance of epimutations in germline, we measured DNA methylation in brain and sperm of rats. Pregnant dams were exposed from day 8–18 of gestation to low dosages of VIN, A1221, or the vehicle. To produce paternal lineages, exposed F1 males were bred with untreated females, creating the F2 and subsequently F3 generations. In adult F1 and F3 males, mature sperm was collected, and brain nuclei involved in anxiety and social behaviors (CA3 of the hippocampus; central amygdala) were selected for assays of epimutations in CpG islands using reduced representation bisulfite sequencing. In F1 sperm, VIN and PCBs induced differential methylation in 215 and 284 CpG islands, respectively, compared to vehicle. The majority of effects were associated with hypermethylation. Fewer epimutations were detected in the brain. A subset of differentially methylated regions were retained from the F1 to the F3 generation, suggesting a common mechanism of EDC and germline epigenome interaction. Thus, EDCs can cause heritable epimutations in the sperm that may embody the future phenotype of brain-behavior disorders caused by direct or transgenerational exposures.
DOI: 10.6084/m9.figshare.7352447
title: Bacteria diversity analysis.zip

description: soil bacteria diversity
DOI: 10.7284/124497
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-16 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352441.v1
title: Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm

description: All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the fungicide vinclozolin (VIN) perturb hormone signaling and lead to dysfunctions following prenatal exposures. Beyond direct exposures, transgenerational disease phenotypes can persist for multiple generations without subsequent exposure. The mechanisms of action of these EDCs differ: VIN is anti-androgenic while the PCB mixture Aroclor 1221 (A1221) is weakly estrogenic. Based on limited evidence for the inheritance of epimutations in germline, we measured DNA methylation in brain and sperm of rats. Pregnant dams were exposed from day 8–18 of gestation to low dosages of VIN, A1221, or the vehicle. To produce paternal lineages, exposed F1 males were bred with untreated females, creating the F2 and subsequently F3 generations. In adult F1 and F3 males, mature sperm was collected, and brain nuclei involved in anxiety and social behaviors (CA3 of the hippocampus; central amygdala) were selected for assays of epimutations in CpG islands using reduced representation bisulfite sequencing. In F1 sperm, VIN and PCBs induced differential methylation in 215 and 284 CpG islands, respectively, compared to vehicle. The majority of effects were associated with hypermethylation. Fewer epimutations were detected in the brain. A subset of differentially methylated regions were retained from the F1 to the F3 generation, suggesting a common mechanism of EDC and germline epigenome interaction. Thus, EDCs can cause heritable epimutations in the sperm that may embody the future phenotype of brain-behavior disorders caused by direct or transgenerational exposures.
DOI: 10.7284/126343
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE16-17 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352423
title: Allelopathic vs. autotoxic potential of a grassland weed—evidence from a seed germination experiment

description: <b>Background</b>: Mechanisms affecting invasiveness of non-indigenous species have received much attention. Few studies have investigated invasions by native plants. Invasive native species such as common ragwort (<i>Jacobaea vulgaris</i>) may become noxious weeds. They challenge farming and nature conservation by outcompeting fodder plants or rare herbs. One mechanism that can result in outcompeting plants is by allelopathy. <b>Aim</b>: We evaluated the potential of <i>J. vulgaris</i> to suppress germination in common and rare grassland species by allelopathy. <b>Methods</b>: In a germination chamber experiment, we exposed 22 species and <i>J. vulgaris</i> itself to ragwort leachate. We controlled for osmotic effects by germination tests in mannitol solution and water. We assessed germination percentage—time —synchrony and radicle length. <b>Results</b>: Leachate reduced germination percentage, germination time, synchrony and radicle length. These effects were similar for <i>J. vulgaris</i>, indicating autotoxicity. Rare species germinated less than common species but were not more sensitive to the phytotoxic effects of <i>J. vulgaris</i>. Restraining effects of the leachate were similar to the mere osmotic effect. <b>Conclusion</b>: Our results question allelopathy as the main driving mechanism behind <i>J. vulgaris</i> gaining dominance. However, the impact of <i>J. vulgaris</i> might depend on the composition of the invaded plant community due to species-specific effects.
DOI: 10.7284/124498
title: Barometer data collected during research cruise PE16-17 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352423.v1
title: Allelopathic vs. autotoxic potential of a grassland weed—evidence from a seed germination experiment

description: <b>Background</b>: Mechanisms affecting invasiveness of non-indigenous species have received much attention. Few studies have investigated invasions by native plants. Invasive native species such as common ragwort (<i>Jacobaea vulgaris</i>) may become noxious weeds. They challenge farming and nature conservation by outcompeting fodder plants or rare herbs. One mechanism that can result in outcompeting plants is by allelopathy. <b>Aim</b>: We evaluated the potential of <i>J. vulgaris</i> to suppress germination in common and rare grassland species by allelopathy. <b>Methods</b>: In a germination chamber experiment, we exposed 22 species and <i>J. vulgaris</i> itself to ragwort leachate. We controlled for osmotic effects by germination tests in mannitol solution and water. We assessed germination percentage—time —synchrony and radicle length. <b>Results</b>: Leachate reduced germination percentage, germination time, synchrony and radicle length. These effects were similar for <i>J. vulgaris</i>, indicating autotoxicity. Rare species germinated less than common species but were not more sensitive to the phytotoxic effects of <i>J. vulgaris</i>. Restraining effects of the leachate were similar to the mere osmotic effect. <b>Conclusion</b>: Our results question allelopathy as the main driving mechanism behind <i>J. vulgaris</i> gaining dominance. However, the impact of <i>J. vulgaris</i> might depend on the composition of the invaded plant community due to species-specific effects.
DOI: 10.7284/124594
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-17 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124502
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-17 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124499
title: Hygrometer data collected during research cruise PE16-17 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124500
title: Transmissometer data collected during research cruise PE16-17 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124501
title: TSG (Thermosalinograph) data collected during research cruise PE16-17 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126344
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE16-18 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124503
title: Barometer data collected during research cruise PE16-18 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124595
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-18 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124507
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-18 using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124504
title: Hygrometer data collected during research cruise PE16-18 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition