cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48677/16265e0b-2135-4909-a813-6a910ed06828
title: Kartographisches Modell 1:500 000 Vektor - Höhenlinien Stichtag 01.07.2022

description: Dieser Datensatz entspricht den Höhenschichtlinien des Objektbereichs Geländedarstellung des KM500-V. Das Kartographische Modell 1:500 000 - Vektor (KM500-V) beinhaltet die maßstabsbezogenen generalisierten Vektordaten der topographischen Übersichtskarte von Österreich im Maßstab 1:500 000. 

Das KM500-V ist gegliedert in die Objektbereiche Geländedarstellung, Gewässer, Grenzen (Staats-, Landes- und Bezirksgrenzen), Siedlungen (Signaturen und geographische Namen), Vegetation und Verkehr.

Stichtag = Erstellungsdatum:
Die Daten sind zu diesem Tag der aktuellste Datenbestand des BEV.
Dies ist nicht ident mit dem Aufnahme- bzw. Vermessungsdatum.
DOI: 10.5517/ccdc.csd.cc2h7l3g
title: CCDC 2301195: Experimental Crystal Structure Determination

description: Related Article: Yuma Shiratori, Julong Jiang, Koji Kubota, Satoshi Maeda, Hajime Ito|2024|J.Am.Chem.Soc.|146|1765|doi:10.1021/jacs.3c11851
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.10566351
title: Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation

description: Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S. Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation. J Mol Biol. 2023 Dec 15;435(24):168320. doi: 10.1016/j.jmb.2023.168320. Epub 2023 Oct 20. PMID: 37865287.

Abstract



Light chain amyloidosis (AL) is a systemic disease where fibrillar deposition of misfolded immunoglobulin light chains (LCs) severely affects organ function and results in poor prognosis for patients, especially when heart involvement is severe. Particularly relevant in this context is the cardiotoxicity exerted by still uncharacterized soluble LC species. Here, with the final goal of identifying alternative therapeutic strategies to tackle AL amyloidosis, we produced five llama-derived nanobodies (Nbs) specific against H3, a well-characterized amyloidogenic and cardiotoxic LC from an AL patient with severe cardiac involvement. We found that Nbs are specific and potent agents capable of abolishing H3 soluble toxicity in C. elegans in vivo model. Structural characterization of H3-Nb complexes revealed that the protective effect of Nbs is related to their ability to bind to the H3 VL domain and stabilise an unexpected partially open LC dimer in which the two VL domains no longer interact with each other. Thus, while identifying potent inhibitors of LC soluble toxicity, we also describe the first non-native structure of an amyloidogenic LC that may represent a crucial step in toxicity and aggregation mechanisms.
DOI: 10.5281/zenodo.10566352
title: Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation

description: Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S. Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation. J Mol Biol. 2023 Dec 15;435(24):168320. doi: 10.1016/j.jmb.2023.168320. Epub 2023 Oct 20. PMID: 37865287.

Abstract



Light chain amyloidosis (AL) is a systemic disease where fibrillar deposition of misfolded immunoglobulin light chains (LCs) severely affects organ function and results in poor prognosis for patients, especially when heart involvement is severe. Particularly relevant in this context is the cardiotoxicity exerted by still uncharacterized soluble LC species. Here, with the final goal of identifying alternative therapeutic strategies to tackle AL amyloidosis, we produced five llama-derived nanobodies (Nbs) specific against H3, a well-characterized amyloidogenic and cardiotoxic LC from an AL patient with severe cardiac involvement. We found that Nbs are specific and potent agents capable of abolishing H3 soluble toxicity in C. elegans in vivo model. Structural characterization of H3-Nb complexes revealed that the protective effect of Nbs is related to their ability to bind to the H3 VL domain and stabilise an unexpected partially open LC dimer in which the two VL domains no longer interact with each other. Thus, while identifying potent inhibitors of LC soluble toxicity, we also describe the first non-native structure of an amyloidogenic LC that may represent a crucial step in toxicity and aggregation mechanisms.
DOI: 10.48801/eubrewnet.izana
title: EUBREWNET ozone products for the Izana (Spain) station
DOI: 10.48801/eubrewnet.madrid
title: EUBREWNET ozone products for the Madrid (Spain) station
DOI: 10.48801/eubrewnet.uccle
title: EUBREWNET ozone products for the Uccle (Belgium) station
DOI: 10.25403/upresearchdata.25035812
title: Skills development for community youth through an El Sistema inspired community music programme in South Africa

description: In this study, I aimed to discover the potential avenues within the context of an El Sistema-inspired community music programme, particularly when integrated with an urban residential tertiary institution in South Africa. The objectives of this study were to identify the necessary physical and human resources for initiating an El Sistema-inspired community music programme, to explore the adaptation of such a programme to suit the country’s distinctive cultural context, and to elucidate the music education opportunities it could extend to the youth in South Africa. Three main themes emerged from data analysis namely collaboration, sustainability, and development of human potential. Interpreting the data revealed that these three themes are interconnected factors that set off a chain reaction, ultimately culminating in the success of a community music programme. Several subthemes evolved, such as crossing cultural barriers through music, integrating community music with tertiary music studies to develop teaching skills, contributing towards skills development for both community youth members and tertiary music students, as well as the wellbeing and upliftment of the broader community. In conclusion, this research underscores the intricate interplay of collaboration, sustainability, and human potential development as essential components for the success of an El Sistema-inspired community music programme in South Africa, shedding light on the transformative impact such an initiative may exert on individuals, communities, and the broader cultural fabric.
DOI: 10.25403/upresearchdata.25035812.v2
title: Skills development for community youth through an El Sistema inspired community music programme in South Africa

description: In this study, I aimed to discover the potential avenues within the context of an El Sistema-inspired community music programme, particularly when integrated with an urban residential tertiary institution in South Africa. The objectives of this study were to identify the necessary physical and human resources for initiating an El Sistema-inspired community music programme, to explore the adaptation of such a programme to suit the country’s distinctive cultural context, and to elucidate the music education opportunities it could extend to the youth in South Africa. Three main themes emerged from data analysis namely collaboration, sustainability, and development of human potential. Interpreting the data revealed that these three themes are interconnected factors that set off a chain reaction, ultimately culminating in the success of a community music programme. Several subthemes evolved, such as crossing cultural barriers through music, integrating community music with tertiary music studies to develop teaching skills, contributing towards skills development for both community youth members and tertiary music students, as well as the wellbeing and upliftment of the broader community. In conclusion, this research underscores the intricate interplay of collaboration, sustainability, and human potential development as essential components for the success of an El Sistema-inspired community music programme in South Africa, shedding light on the transformative impact such an initiative may exert on individuals, communities, and the broader cultural fabric.
DOI: 10.25403/upresearchdata.25035812.v1
title: Skills development for community youth through an El Sistema inspired community music programme in South Africa

description: In this study, I aimed to discover the potential avenues within the context of an El Sistema-inspired community music programme, particularly when integrated with an urban residential tertiary institution in South Africa. The objectives of this study were to identify the necessary physical and human resources for initiating an El Sistema-inspired community music programme, to explore the adaptation of such a programme to suit the country’s distinctive cultural context, and to elucidate the music education opportunities it could extend to the youth in South Africa. Three main themes emerged from data analysis namely collaboration, sustainability, and development of human potential. Interpreting the data revealed that these three themes are interconnected factors that set off a chain reaction, ultimately culminating in the success of a community music programme. Several subthemes evolved, such as crossing cultural barriers through music, integrating community music with tertiary music studies to develop teaching skills, contributing towards skills development for both community youth members and tertiary music students, as well as the wellbeing and upliftment of the broader community. In conclusion, this research underscores the intricate interplay of collaboration, sustainability, and human potential development as essential components for the success of an El Sistema-inspired community music programme in South Africa, shedding light on the transformative impact such an initiative may exert on individuals, communities, and the broader cultural fabric.
DOI: 10.25502/4473-kb25/d
title: EiA SAA Usecase Nigeria, maize sowing window validation experiment dataset, 2023.
DOI: 10.5281/zenodo.10566327
title: Minimally Invasive Surgery for Simple Congenital Heart Defects Preserving Aesthetics without Jeopardizing Patient Safety

description: Lo Rito M, Brindicci YCM, Moscatiello M, Varrica A, Reali M, Saracino A, Chessa M, Aloisio T, Isgrò G, Giamberti A. Minimally Invasive Surgery for Simple Congenital Heart Defects: Preserving Aesthetics without Jeopardizing Patient Safety. J Cardiovasc Dev Dis. 2023 Nov 6;10(11):452. doi: 10.3390/jcdd10110452. PMID: 37998510; PMCID: PMC10672407.

Abstract



Minimally invasive surgeries for pediatric patients have been proposed for decades, with different approaches in mind. Minimal right axillary thoracotomy (MRAT), proposed two decades ago, allows the preservation of patients' safety alongside faster aesthetic and functional recovery. The MRAT did not become widely adopted due to the prejudice that to follow a minimally invasive approach, safety and efficacy must be compromised. With this study, we aim to compare MRAT to the standard median sternotomy approach with a focus on safety and clinical outcomes. Between January 2017 and April 2021, 216 patients diagnosed with ASD, pAVSD, or PAPVD underwent surgical repair with different approaches in the same period. MRAT was used for 78 patients, and median sternotomy was used for 138 patients. In this last group, standard median sternotomy (SMS) was used for 116 patients, while a minimal skin incision (SMS mini) was used for 22 patients. There were no major complications overall nor in each specific approach. MRAT enabled the successful repair of simple heart defects, providing similar post-operative and cardiological recovery. MRAT does not compromise patients' safety and does not prolong the duration of surgery once the learning curve is overcome, which is generally after 15-20 consecutive operations.
DOI: 10.5281/zenodo.10566328
title: Minimally Invasive Surgery for Simple Congenital Heart Defects Preserving Aesthetics without Jeopardizing Patient Safety

description: Lo Rito M, Brindicci YCM, Moscatiello M, Varrica A, Reali M, Saracino A, Chessa M, Aloisio T, Isgrò G, Giamberti A. Minimally Invasive Surgery for Simple Congenital Heart Defects: Preserving Aesthetics without Jeopardizing Patient Safety. J Cardiovasc Dev Dis. 2023 Nov 6;10(11):452. doi: 10.3390/jcdd10110452. PMID: 37998510; PMCID: PMC10672407.

Abstract



Minimally invasive surgeries for pediatric patients have been proposed for decades, with different approaches in mind. Minimal right axillary thoracotomy (MRAT), proposed two decades ago, allows the preservation of patients' safety alongside faster aesthetic and functional recovery. The MRAT did not become widely adopted due to the prejudice that to follow a minimally invasive approach, safety and efficacy must be compromised. With this study, we aim to compare MRAT to the standard median sternotomy approach with a focus on safety and clinical outcomes. Between January 2017 and April 2021, 216 patients diagnosed with ASD, pAVSD, or PAPVD underwent surgical repair with different approaches in the same period. MRAT was used for 78 patients, and median sternotomy was used for 138 patients. In this last group, standard median sternotomy (SMS) was used for 116 patients, while a minimal skin incision (SMS mini) was used for 22 patients. There were no major complications overall nor in each specific approach. MRAT enabled the successful repair of simple heart defects, providing similar post-operative and cardiological recovery. MRAT does not compromise patients' safety and does not prolong the duration of surgery once the learning curve is overcome, which is generally after 15-20 consecutive operations.
DOI: 10.23729/0ebd41ae-bf88-4776-9797-b14ff6e78627
title: Koilismaa Set 1

description: Set 1 of Koilismaa data. Collective preview entry at https://doi.org/10.23729/2cbc518e-6f9b-4b3f-ac25-d262a983734b Preview dataset found at https://doi.org/10.23729/41b7a2d5-3958-4391-9e52-2efc9d325688 . To obtain data, please contact fairdata-pas@gtk.fi .
DOI: 10.48801/eubrewnet.el.arenosillo
title: EUBREWNET ozone products for the El Arenosillo (Spain) station
DOI: 10.5281/zenodo.6806676
title: Along flow acceleration of the Greenland ice sheet

description: The acceleration of Greenland ice flow derived from ITS_LIVE annual velocity data spanning 1985-2018.


There are two variations of using either weighted and unweighted least squares in the estimation. The data files follow the format:



	
weighted--ax.tif | acceleration in the x direction:
	
weighted--ay.tif  | acceleration in the y-direction.
	
weighted--a.tif | acceleration in the dominant flow direction
	
weighted--asigma.tif | standard error estimate of the "weighted--a" data.
	
weighted--N.tif | Number of years with data for each grid point.



All data are using a polar stereographic projection (EPSG:3413). 


 


This dataset was created as part of the study: Grinsted et al. 2022, Accelerating ice flow at the onset of the Northeast Greenland ice stream. Processing choices is detailed there. 
description: Acknowledgments: 
This work was supported by the Villum Investigator Project IceFlow (16572), a Dancea grant from the Danish Environmental Protection Agency (EPA), and Villum Foundation Experiment grant (2361). EastGRIP is directed and organized by the Physics of Ice, Climate and Earth group, at the Niels Bohr Institute, University of Copenhagen. It is supported by funding agencies and institutions in Denmark (A. P. Møller Foundation, University of Copenhagen), USA (US National Science Foundation, Office of Polar Programs), Germany (Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research), Japan (National Institute of Polar Research and Arctic Challenge for Sustainability), Norway (University of Bergen and Trond Mohn Foundation), Switzerland (Swiss National Science Foundation), France (French Polar Institute Paul-Emile Victor, Institute for Geosciences and Environmental research), Canada (University of Manitoba) and China (Chinese Academy of Sciences and Beijing Normal University).
DOI: 10.5281/zenodo.6806677
title: Along flow acceleration of the Greenland ice sheet

description: The acceleration of Greenland ice flow derived from ITS_LIVE annual velocity data spanning 1985-2018.


There are two variations of using either weighted and unweighted least squares in the estimation. The data files follow the format:



	
weighted--ax.tif | acceleration in the x direction:
	
weighted--ay.tif  | acceleration in the y-direction.
	
weighted--a.tif | acceleration in the dominant flow direction
	
weighted--asigma.tif | standard error estimate of the "weighted--a" data.
	
weighted--N.tif | Number of years with data for each grid point.



All data are using a polar stereographic projection (EPSG:3413). 


 


This dataset was created as part of the study: Grinsted et al. 2022, Accelerating ice flow at the onset of the Northeast Greenland ice stream. Processing choices is detailed there. 
description: Acknowledgments: 
This work was supported by the Villum Investigator Project IceFlow (16572), a Dancea grant from the Danish Environmental Protection Agency (EPA), and Villum Foundation Experiment grant (2361). EastGRIP is directed and organized by the Physics of Ice, Climate and Earth group, at the Niels Bohr Institute, University of Copenhagen. It is supported by funding agencies and institutions in Denmark (A. P. Møller Foundation, University of Copenhagen), USA (US National Science Foundation, Office of Polar Programs), Germany (Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research), Japan (National Institute of Polar Research and Arctic Challenge for Sustainability), Norway (University of Bergen and Trond Mohn Foundation), Switzerland (Swiss National Science Foundation), France (French Polar Institute Paul-Emile Victor, Institute for Geosciences and Environmental research), Canada (University of Manitoba) and China (Chinese Academy of Sciences and Beijing Normal University).
DOI: 10.5281/zenodo.10567693
title: Supplemental data for Failure strength of glacier ice inferred from Greenland crevasses

description: This archive contains data that were used in the preparation of this study: 

A. Grinsted, N. Rathmann, R. Mottram, A. M. Solgaard, J. Mathiesen, and C.S. Hvidberg. (2024) "Failure strength of glacier ice inferred from Greenland crevasses", The Cryosphere.

 

The study is mostly based on published datasets [see paper for details]. This archive only contains additional data files that were generated as part of this study.  

Aslak Grinsted, january 2024

FILES=============================================================

interior_mask.gpkgA geopackage file with a manually traced polygon of the interior part of the ice sheet. 

opening_crevasses_mask.tifThis is a mask of opening crevasses. Opening crevasses fulfill these criteria (see paper for details): - On the upstream edge of crevasse fields. (Detected using sobel filters and requiring the along flow crevasse density gradient to be positive)- Not inside interior_mask.gpkg - crevasse fraction<5%- Thickness[H]>200

tau_opening.csv- data extracted from various sources for opening crevasses. - Columns: tau_vm[Pa],x[m],y[m],z[m],crevasse_density,v[m/yr],acceleration[m/yr2],T[K],H[m],seasonal_amp[m/yr],zwallyregion,dcdl[m-1],e1[s-1],e2[s-1],t1[Pa],t2[Pa],is_steady
DOI: 10.5281/zenodo.10567694
title: Supplemental data for Failure strength of glacier ice inferred from Greenland crevasses

description: This archive contains data that were used in the preparation of this study: 

A. Grinsted, N. Rathmann, R. Mottram, A. M. Solgaard, J. Mathiesen, and C.S. Hvidberg. (2024) "Failure strength of glacier ice inferred from Greenland crevasses", The Cryosphere.

 

The study is mostly based on published datasets [see paper for details]. This archive only contains additional data files that were generated as part of this study.  

Aslak Grinsted, january 2024

FILES=============================================================

interior_mask.gpkgA geopackage file with a manually traced polygon of the interior part of the ice sheet. 

opening_crevasses_mask.tifThis is a mask of opening crevasses. Opening crevasses fulfill these criteria (see paper for details): - On the upstream edge of crevasse fields. (Detected using sobel filters and requiring the along flow crevasse density gradient to be positive)- Not inside interior_mask.gpkg - crevasse fraction<5%- Thickness[H]>200

tau_opening.csv- data extracted from various sources for opening crevasses. - Columns: tau_vm[Pa],x[m],y[m],z[m],crevasse_density,v[m/yr],acceleration[m/yr2],T[K],H[m],seasonal_amp[m/yr],zwallyregion,dcdl[m-1],e1[s-1],e2[s-1],t1[Pa],t2[Pa],is_steady
DOI: 10.5281/zenodo.10562520
title: Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients

description: Ceserani V, Lo Rito M, Agnifili ML, Pascaner AF, Rosato A, Anglese S, Deamici M, Negri J, Corrado C, Bedogni F, Secchi F, Lombardi M, Auricchio F, Frigiola A, Conti M. Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients. Sci Rep. 2023 Oct 14;13(1):17448. doi: 10.1038/s41598-023-44568-8. PMID: 37838795; PMCID: PMC10576762.

Abstract



Anomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail to assess the ischemic risk, calling for novel diagnostic approaches. To this aim, some recent studies propose to assess the coronary blood flow (CBF) in AAOCA by computational simulations but they are limited by the use of data from literature retrieved from normal subjects. To overcome this limitation and obtain a reliable assessment of CBF, we developed a fully patient-specific lumped parameter model based on clinical imaging and in-vivo data retrieved during invasive coronary functional assessment of subjects with AAOCA. In such a way, we can estimate the CBF replicating the two hemodynamic conditions in-vivo analyzed. The model can mimic the effective coronary behavior with high accuracy and could be a valuable tool to quantify CBF in AAOCA. It represents the first step required to move toward a future clinical application with the aim of improving patient care. The study was registered at Clinicaltrial.gov with (ID: NCT05159791, date 2021-12-16).