cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7900241
title: Correlation of cadherin-17 protein expression with clinicopathological features and prognosis of patients with sporadic gastric cancer

description: This study aimed to explore the correlations between cadherin-17 (CDH17) protein expression and the clinicopathological features and prognosis of patients with sporadic gastric cancer (GC). Nine relevant studies of 1,960 patients were identified using electronic database searches supplemented with a manual search in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 statistical software. Relative risks and 95% confidence intervals were determined, and Z test was used to measure the significance of the overall effect size. A total of nine eligible cohort studies were included in this meta-analysis. The expression of CDH17 in patients with diffuse GC was significantly higher than in those with intestinal-type GC. Moreover, the tumor depth of invasion differed significantly between patients with positive CDH17 (CDH17+) and negative CDH17 (CDH17-) GC. However, there were no significant differences between CDH17+ and CDH17- GC patients with respect to tumor node metastasis clinical stages, histological grades, or lymph node metastasis. Despite the differences in invasive depth, there was no significant difference in 5-year survival rates between CDH17+ and CDH17- GC patients. Our meta-analysis provides evidence that CDH17 protein expression may be associated with the development of GC, suggesting that CDH17 is an important biomarker that could be useful for the early diagnosis of GC. However, CDH17 levels do not appear to impact overall survival.
DOI: 10.6084/m9.figshare.7900244
title: An Amorphous Silicon Photo TFT with Si3N4/Al2O3 or HfO2 Double Layered Insulator for Digital Imaging Applications

description: Abstract This paper focuses on amorphous silicon photo thin-film transistors with double layered insulator using Si3N4/Al2O3 or HfO2 as candidates for the succession of Si3N4 as a traditional insulator in the fabrication of hydrogenated amorphous silicon thin-film transistors. Whether for industry or for research, there is a need to investigate the use of thin gate insulators for these devices to overcome leakage current. Our investigations included direct and transfer characteristics in dark and under illumination, generated photocurrents, external quantum efficiency and responsivity. Performance is evaluated in terms of the dielectric thickness and nature. Improvements in the proposed structures regarding off-current, responsivity and quantum efficiency are achieved via these materials. Comparing with Si3N4/HfO2 transistor, the Si3N4/Al2O3 device shows the lowest off-current. The HfO2 device presents the highest on-current when illuminated. The generated photocurrent is higher for Si3N4/HfO2 transistor revealing a lower amount of trapped charge. Under illumination and for very thin thicknesses, both devices enhance the Si3N4 device off-current and reach Si3N4 single layer dielectric based phototransistor performance. external quantum efficiency and responsivity are higher in HfO2 devices comparing with Al2O3 devices. The results are promising and may support further investigations in order to develop high k gate insulators for MIS photo thin-film transistors.
DOI: 10.6084/m9.figshare.7900247.v1
title: Compact Filtenna for WLAN Applications

description: Abstract This manuscript proposes a Filtenna operating in the frequency range of 5.15-5.35 GHz for possible application in wireless local area network (WLAN). Initially, a monopole antenna consisting of a square loop radiating patch is designed at 5.2 GHz and is integrated into a bandpass filter (BPF) with centre frequency of 5.2 GHz. Within the proposed frequency band of operation, the filtenna exhibits omni-directional radiation pattern, good selectivity and low reflection loss. Also, the VSWR observed is less than 2 and peak antenna gain is approximately 2.5 dBi within the frequency range. A consistency is obtained between the simulation and the experiment.
DOI: 10.6084/m9.figshare.7900250.v1
title: The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro - oncology center

description: ABSTRACT Introduction: In view of the detailed histologic evaluation of prostate cancer (PC), it is usually advisable to provide a “second opinion” to confirm diagnosis. This study aimed to compare the Gleason score (GS) of initial diagnosis versus that of histopathologic review of patients with PC. The secondary objective was to compare initial GS versus histopathologic review versus post - surgical histopathology. Material and methods: Retrospective study based on chart review of patients with PC that attended the Uro - oncology Department of Hospital das Clínicas - UNICAMP - Campinas, Brazil, from April, 2002, to April, 2012. Data were divided in groups: patients with biopsies performed elsewhere, biopsies after pathological review and histopathological results following retropubic radical prostatectomy (RRP). These were evaluated in relation to GS difference using Fleis's Kappa concordance coefficient. Results: 402 PC patients, with a median age of 66 years, were evaluated. Reviewed GS showed worsening, with accuracy of 61.2%, and Kappa concordance value = 0.466. Among 143 patients submitted to surgery, GS varied widely, regarding initial evaluation, review and post - surgical RRP. Joint concordance of evaluations was weak (Kappa = 0.216), mainly due to almost no existence concordance between initial evaluation and following RRP (Kappa = 0.041). Conclusion: There is a great histopathological variation of initial GS versus reviewed GS. There is also a better correlation of reviewed GS and post - surgical GS than with initial GS. The second opinion by an uropathologist improves diagnosis and should be advised for better therapeutic decision.
DOI: 10.6084/m9.figshare.7900235
title: The impact of single positive surgical margin features on biochemical recurrence after robotic radical prostatectomy

description: ABSTRACT Objective: Parameters predictive of biochemical or clinical recurrence after Radical Prostatectomy (RP) were determined as pre-treatment PSA value, pathologic tumor stage, tumor grade and presence of Positive Surgical Margin (PSM), extracapsular extension and seminal vesicle invasion and the status of pelvic lymph nodes. The aim of our study is to evaluate the effect of additional features in patients undergoing RP in our clinic. Materials and Methods: We studied 556 RP operations performed between 2009 and 2016 for prostate cancer at this clinic. Preoperative and postoperative data of the patients were retrospectively reviewed. RP specimens were examined by two pathologists specialized in this subject. Of these patients, 78 (14.02%) patients with PSM were included in the study. The pathology slides of these patients were reassessed. The length of PSM (mm), localization (apex, basis and posterolateral) and Gleason pattern at this margin was determined and statistical correlations with BCR were calculated. Results: The mean follow-up after the RP of 41 patients included in the study was 37.4 ± 13.2 months. During the follow-up period of the patients, BCR was observed in 16 patients (39.02%). No statistically significant difference was observed in age and prostate volume between the groups with and without BCR development (p &gt; 0.05). Preoperative PSA level was found to be statistically significantly higher in the group with BCR development compared to the group without recurrence (p = 0.004). In-group comparisons in each aforementioned Gleason score groups were performed in terms of BCR development and the preoperative Gleason score in the group with development of recurrence was found to be statistically significantly higher compared to the group without recurrence (p = 0.007). The length of the surgical margin was measured as 7.4 ± 4.4 mm in the BCR-developing group and 4.7 ± 3.8 mm in the no-BCR- developing group; it was statistically significantly higher in the group with development of recurrence (p = 0.03). Conclusion: Length and location of the PSM and the Gleason score detected in the PSM region could not predict biochemical recurrence according to the results of this present study. However high preoperative PSA value is an independent prognostic factor for biochemical recurrence.
DOI: 10.6084/m9.figshare.7900244.v1
title: An Amorphous Silicon Photo TFT with Si3N4/Al2O3 or HfO2 Double Layered Insulator for Digital Imaging Applications

description: Abstract This paper focuses on amorphous silicon photo thin-film transistors with double layered insulator using Si3N4/Al2O3 or HfO2 as candidates for the succession of Si3N4 as a traditional insulator in the fabrication of hydrogenated amorphous silicon thin-film transistors. Whether for industry or for research, there is a need to investigate the use of thin gate insulators for these devices to overcome leakage current. Our investigations included direct and transfer characteristics in dark and under illumination, generated photocurrents, external quantum efficiency and responsivity. Performance is evaluated in terms of the dielectric thickness and nature. Improvements in the proposed structures regarding off-current, responsivity and quantum efficiency are achieved via these materials. Comparing with Si3N4/HfO2 transistor, the Si3N4/Al2O3 device shows the lowest off-current. The HfO2 device presents the highest on-current when illuminated. The generated photocurrent is higher for Si3N4/HfO2 transistor revealing a lower amount of trapped charge. Under illumination and for very thin thicknesses, both devices enhance the Si3N4 device off-current and reach Si3N4 single layer dielectric based phototransistor performance. external quantum efficiency and responsivity are higher in HfO2 devices comparing with Al2O3 devices. The results are promising and may support further investigations in order to develop high k gate insulators for MIS photo thin-film transistors.
DOI: 10.6084/m9.figshare.7900229
title: The role of kinship in knowledge about medicinal plants: evidence for context-dependent model-based biases in cultural transmission?

description: ABSTRACT The similarity in traditional knowledge of medicinal plants was evaluated to draw inferences about the most important models for local knowledge transmission. The following questions were addressed: (1) Do related individuals possess greater similarity in knowledge of medicinal plants than unrelated individuals? (2) Do related individuals of the same generation possess greater similarity in knowledge than do related individuals of different generations? Semi-structured interviews were conducted on the medicinal plants known by the residents of a rural community in western Bahia. Mann-Whitney tests were used to compare Jaccard similarity values between related and unrelated individuals and between relatives of the same generation and relatives of different generations. Related individuals were found to have more similar knowledge than unrelated individuals, and relatives of the same generation were found to have more similar knowledge than relatives of different generations. These findings suggest that there are factors that favor cultural transmission between relatives of the same generation other than just vertical transmission.
DOI: 10.6084/m9.figshare.7900232
title: Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages

description: This study aimed to determine the effects of different concentrations of propofol (2,6-diisopropylphenol) on lipopolysaccharide (LPS)-induced expression and release of high-mobility group box 1 protein (HMGB1) in mouse macrophages. Mouse macrophage cell line RAW264.7 cells were randomly divided into 5 treatment groups. Expression levels of HMGB1 mRNA were detected using RT-PCR, and cell culture supernatant HMGB1 protein levels were detected using enzyme-linked immunosorbent assay (ELISA). Translocation of HMGB1 from the nucleus to the cytoplasm in macrophages was observed by Western blotting and activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in the nucleus was detected using ELISA. HMGB1 mRNA expression levels increased significantly in the cell culture supernatant and in cells after 24 h of stimulating RAW264.7 cells with LPS (500 ng/mL). However, HMGB1 mRNA expression levels in the P2 and P3 groups, which received 500 ng/mL LPS with 25 or 50 μmol/mL propofol, respectively, were significantly lower than those in the group receiving LPS stimulation (P&lt;0.05). After stimulation by LPS, HMGB1 protein levels were reduced significantly in the nucleus but were increased in the cytoplasm (P&lt;0.05). Simultaneously, the activity of NF-κB was enhanced significantly (P&lt;0.05). After propofol intervention, HMGB1 translocation from the nucleus to the cytoplasm and NF-κB activity were inhibited significantly (each P&lt;0.05). Thus, propofol can inhibit the LPS-induced expression and release of HMGB1 by inhibiting HMGB1 translocation and NF-κB activity in RAW264.7 cells, suggesting propofol may be protective in patients with sepsis.
DOI: 10.6084/m9.figshare.7900235.v1
title: The impact of single positive surgical margin features on biochemical recurrence after robotic radical prostatectomy

description: ABSTRACT Objective: Parameters predictive of biochemical or clinical recurrence after Radical Prostatectomy (RP) were determined as pre-treatment PSA value, pathologic tumor stage, tumor grade and presence of Positive Surgical Margin (PSM), extracapsular extension and seminal vesicle invasion and the status of pelvic lymph nodes. The aim of our study is to evaluate the effect of additional features in patients undergoing RP in our clinic. Materials and Methods: We studied 556 RP operations performed between 2009 and 2016 for prostate cancer at this clinic. Preoperative and postoperative data of the patients were retrospectively reviewed. RP specimens were examined by two pathologists specialized in this subject. Of these patients, 78 (14.02%) patients with PSM were included in the study. The pathology slides of these patients were reassessed. The length of PSM (mm), localization (apex, basis and posterolateral) and Gleason pattern at this margin was determined and statistical correlations with BCR were calculated. Results: The mean follow-up after the RP of 41 patients included in the study was 37.4 ± 13.2 months. During the follow-up period of the patients, BCR was observed in 16 patients (39.02%). No statistically significant difference was observed in age and prostate volume between the groups with and without BCR development (p &gt; 0.05). Preoperative PSA level was found to be statistically significantly higher in the group with BCR development compared to the group without recurrence (p = 0.004). In-group comparisons in each aforementioned Gleason score groups were performed in terms of BCR development and the preoperative Gleason score in the group with development of recurrence was found to be statistically significantly higher compared to the group without recurrence (p = 0.007). The length of the surgical margin was measured as 7.4 ± 4.4 mm in the BCR-developing group and 4.7 ± 3.8 mm in the no-BCR- developing group; it was statistically significantly higher in the group with development of recurrence (p = 0.03). Conclusion: Length and location of the PSM and the Gleason score detected in the PSM region could not predict biochemical recurrence according to the results of this present study. However high preoperative PSA value is an independent prognostic factor for biochemical recurrence.
DOI: 10.6084/m9.figshare.7900238.v1
title: Pervious concrete: study of dosage and polypropylene fibers addiction

description: Abstract The use of pervious concrete to minimize the effects caused by the impermeability of the soil as a result of increasing urbanization is an alternative that still requires further studies regarding its design and implementation. From this perspective, this paper presents a study of the characteristics of pervious concrete, including its tensile strength, compressive strength, flexural strength and the permeability coefficient, through the development of various mixtures to adjust the characteristics of the local aggregates. Eight mixtures were studied based on a reference mixture, five of which were related to the pervious concrete with the addition of finer aggregates than the reference mixture without these aggregates. Subsequently, three mixtures were studied with the inclusion of polypropylene fibers in order to analyze the effects of the addition of fibers on the properties of the pervious concrete. It is concluded that the presence of fibers changed the characteristics of the concrete, increasing its strengths while achieving a good permeability in its mixtures. An improvement in the flexural strength of the pervious concrete was observed, which is the main property to be considered for its use in pavements, without harming the permeability, which raises the possibility for its application.
DOI: 10.6084/m9.figshare.7900241.v1
title: Correlation of cadherin-17 protein expression with clinicopathological features and prognosis of patients with sporadic gastric cancer

description: This study aimed to explore the correlations between cadherin-17 (CDH17) protein expression and the clinicopathological features and prognosis of patients with sporadic gastric cancer (GC). Nine relevant studies of 1,960 patients were identified using electronic database searches supplemented with a manual search in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 statistical software. Relative risks and 95% confidence intervals were determined, and Z test was used to measure the significance of the overall effect size. A total of nine eligible cohort studies were included in this meta-analysis. The expression of CDH17 in patients with diffuse GC was significantly higher than in those with intestinal-type GC. Moreover, the tumor depth of invasion differed significantly between patients with positive CDH17 (CDH17+) and negative CDH17 (CDH17-) GC. However, there were no significant differences between CDH17+ and CDH17- GC patients with respect to tumor node metastasis clinical stages, histological grades, or lymph node metastasis. Despite the differences in invasive depth, there was no significant difference in 5-year survival rates between CDH17+ and CDH17- GC patients. Our meta-analysis provides evidence that CDH17 protein expression may be associated with the development of GC, suggesting that CDH17 is an important biomarker that could be useful for the early diagnosis of GC. However, CDH17 levels do not appear to impact overall survival.
DOI: 10.6084/m9.figshare.7900226
title: Brimonidine-induced unilateral ocular lichen planus: a case report

description: ABSTRACT This report was written to describe a case of unilateral brimonidine-induced conjunctival lichen planus. Because the ophthalmic examination indicated chronic conjunctivitis or drug-induced pseudopemphigoid, the patient underwent thorough ophthalmic and systemic examinations, as well as conjunctival biopsy and direct immunofluorescence studies. A 71-year-old woman with unilateral left eye findings of chronic conjunctivitis was referred to our Ophthalmology Department. The patient reported that chronic conjunctivitis began shortly after she initiated use of topical brimonidine. Ophthalmic examination revealed foreshortening of the inferior fornix and symblepharon. Conjunctival biopsy revealed submucous lymphocytes and shaggy distribution of fibrinogen on direct immunofluorescence; this was suggestive of ocular lichen planus. No other systemic lesions were found that were consistent with the presentation of lichen planus. A good response was observed to topical cyclosporine treatment. To our knowledge, this may be the first report of unilateral ocular lichen planus without systemic findings. The correlation with the initiation of topical brimonidine suggests that this might be the first case of biopsy-confirmed brimonidine-induced ocular lichen planus.
DOI: 10.6084/m9.figshare.7900232.v1
title: Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages

description: This study aimed to determine the effects of different concentrations of propofol (2,6-diisopropylphenol) on lipopolysaccharide (LPS)-induced expression and release of high-mobility group box 1 protein (HMGB1) in mouse macrophages. Mouse macrophage cell line RAW264.7 cells were randomly divided into 5 treatment groups. Expression levels of HMGB1 mRNA were detected using RT-PCR, and cell culture supernatant HMGB1 protein levels were detected using enzyme-linked immunosorbent assay (ELISA). Translocation of HMGB1 from the nucleus to the cytoplasm in macrophages was observed by Western blotting and activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in the nucleus was detected using ELISA. HMGB1 mRNA expression levels increased significantly in the cell culture supernatant and in cells after 24 h of stimulating RAW264.7 cells with LPS (500 ng/mL). However, HMGB1 mRNA expression levels in the P2 and P3 groups, which received 500 ng/mL LPS with 25 or 50 μmol/mL propofol, respectively, were significantly lower than those in the group receiving LPS stimulation (P&lt;0.05). After stimulation by LPS, HMGB1 protein levels were reduced significantly in the nucleus but were increased in the cytoplasm (P&lt;0.05). Simultaneously, the activity of NF-κB was enhanced significantly (P&lt;0.05). After propofol intervention, HMGB1 translocation from the nucleus to the cytoplasm and NF-κB activity were inhibited significantly (each P&lt;0.05). Thus, propofol can inhibit the LPS-induced expression and release of HMGB1 by inhibiting HMGB1 translocation and NF-κB activity in RAW264.7 cells, suggesting propofol may be protective in patients with sepsis.
DOI: 10.6084/m9.figshare.7900217
title: Hypertension Prevalence, Treatment and Control in Older Adults in a Brazilian Capital City

description: Abstract Background: The diagnosis, treatment and control of arterial hypertension are fundamental for a reduction in cardiovascular outcomes, especially in the elderly. In Brazil, there are few studies that specifically identified these rates in the elderly population. Objective: To verify rates of prevalence, treatment and control of hypertension in elderly people living in the urban area of a Brazilian capital city. Methods: A cross-sectional, population-based, randomized, cluster-based study with 912 non-institutionalized elderly individuals (≥ 60 years), living in urban areas in the city of Goiania, Midwest Brazil. Predictor variables were: age, gender, socioeconomic and lifestyle aspects. Blood pressure measurements were performed at home; patients were considered as having arterial hypertension when SBP and/or DBP ≥ 140/90 mmHg or when using antihypertensive drugs (dependent variable). Rates of hypertension treatment and control were evaluated. Variable association analyses were performed by multivariate logistic regression and level of significance was set at 5%. Results: The prevalence of arterial hypertension was 74.9%, being higher (78.6%) in men (OR 1.4, 95% CI: 1.04-1.92); the treatment rate was 72.6%, with higher rates being observed in smokers (OR 2.06, 95% CI: 1.28-3.33). The rate of hypertension control was 50.8%,being higher in women (OR 1.57, 95% CI: 1.19-2.08). Conclusion: The prevalence rates were high. Treatment and control rates were low and associated with gender, age and lifestyle, indicating the need for early and individual interventions.