cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12956417
title: Gestational diabetes mellitus is associated with antenatal hypercoagulability and hyperfibrinolysis: a case control study of Chinese women

description: To determine the relationship between gestational diabetes mellitus (GDM) and coagulation/fibrinolysis abnormality in antenatal Chinese women. Case control study: 50 women had GDM and 132 did not (the NGDM group) grouping by the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Maternal plasma biochemistry and previous medical history were collected from perinatal health records. Antenatal coagulation/fibrinolysis activity (CFA) parameters were assessed using thromboelastography and routine CFA parameters, respectively. Univariate and multiple regression analyses were used to evaluate the associations between GDM and CFA parameters. Maternal age, platelet, ALT, ALP, urea nitrogen, and previous history of abortion were taken as the covariables. The women with GDM were significantly older than those without GDM (30.3 vs. 28.6 years, <i>p</i> = .012). Compared with the NGDM group, the GDM group had a significantly higher prevalence of cesarean delivery (56.0 vs. 37.9%, <i>p</i> = .027) and higher values of fibrinogen (FIB; 4.7 vs. 4.3 g/L, <i>p</i> = .001), activated partial thromboplastin time (APTT; 30.9 vs. 29.5 s, <i>p</i> = .010).There were no significant differences in the prevalence of maternal thrombotic events or neonatal events. GDM was significantly associated with higher APTT (<i>β</i> =1.41 s, 95% CI: 0.29–2.53), higher FIB (<i>β</i> = 0.38 g/L, 95% CI: 0.14–0.61), and higher percentage reduction in clot lysis after 30 min (LY30; <i>β</i> = 1.14%, 95% CI: 0.15–2.13) after adjustment for potential confounding factors. GDM is significantly associated with hypercoagulability and hyperfibrinolysis in these antenatal Chinese women.
DOI: 10.6084/m9.figshare.20296450
title: Additional file 18 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 18: Supplementary table 8.
DOI: 10.6084/m9.figshare.20296375.v1
title: Additional file 4 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 4: Table S2. Expression of miR-22-3p in AD blood dataset GSE120584.
DOI: 10.6084/m9.figshare.21345005.v1
title: Risk factors for immune-mediated hepatotoxicity in patients with cancer treated with immune checkpoint inhibitors: a systematic review and meta-analysis

description: Immune checkpoint inhibitors (ICIs) are effective for the treatment of various cancers, but can lead to immune-mediated hepatotoxicity (IMH). The aim of this study was to analyze the risk factors for IMH in cancer patients treated with ICIs. The PubMed, EMBASE, and Cochrane Library databases were searched. Eligible studies should compare the difference between patients who developed and did not develop IMH. Odds ratio (OR) and weighted mean difference (WMD) with 95% confidence interval (CI) were calculated. Among the 5030 papers initially identified, 13 studies were included. Meta-analyses indicated that age (WMD: −5.200, 95%CI: −7.481 to −2.919), history of ICIs treatment (OR: 4.491, 95%CI: 2.205 to 9.145), ICIs combination therapy (OR: 5.353, 95%CI: 1.663 to 17.232), and aspartate aminotransferase (AST) level (WMD: 5.039, 95%CI: 1.220 to 8.857) were significantly associated with the risk of any grade IMH; and age (WMD: −5.193; 95%CI: −9.669 to −0.718) was significantly associated with the risk of grade ≥3 IMH. These findings provide the evidence for identifying patients at a high risk of IMH. Appropriate intervention may be given to prevent from IMH in high-risk patients, thereby enabling ICIs to achieve an expected tumor response. PLAIN LANGUAGE SUMMARY At present, immune checkpoint inhibitors (ICIs) are one of the most important treatment choices for cancer. ICIs can enhance the antitumor response by inhibiting the immune checkpoint pathway. The immune checkpoint pathways include CTLA-4 pathway and PD-1 pathway, which inhibit the activation of the immune system. Among them, CTLA-4 pathway stops potentially autoreactive T-cell at the initial stage of T-cell activation, and the PD-1 pathway regulates activated T-cell at the later stage of an immune response. However, excessively enhanced immune activity may cause immune cells to attack health organs like the liver, developing immune-mediated hepatotoxicity (IMH), which may affect the tumor response of ICIs. Therefore, it is crucial to explore the risk factors for IMH in cancer patients treated with ICIs. We searched 3 medical databases: PubMed, EMBASE, and Cochrane Library, and then the studies that evaluated the difference between patients who developed and did not develop IMH were included in our systematic review and meta-analysis. The meta-analyses showed younger patients, patients with history of ICIs treatment, patients who had ICIs combination therapy, and patients with higher liver enzyme AST levels were more likely to develop IMH. Therefore, doctors should pay more attention to the patients at high-risk for IMH with the goal of improving the chances that they achieve a good response from their ICIs therapy.
DOI: 10.6084/m9.figshare.20296435.v1
title: Additional file 13 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 13: Supplementary table 3.
DOI: 10.6084/m9.figshare.20296438
title: Additional file 14 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 14: Supplementary table 4.
DOI: 10.6084/m9.figshare.20296381.v1
title: Additional file 6 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 6: Table S4. Flow cytometry results of blank group and Aβ modeling group.
DOI: 10.6084/m9.figshare.20296387.v1
title: Additional file 8 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 8: Table S6. Flow cytometry results of miR-22-3p acting on AD cell model.
DOI: 10.6084/m9.figshare.20296450.v1
title: Additional file 18 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 18: Supplementary table 8.
DOI: 10.6084/m9.figshare.13488792
title: Seasonally resolved NEEM Be10 for 1887-1950

description: <strong>Supplementary dataset to Zheng et al., "Solar activity of the past 100 years inferred from 10Be in ice cores – implications for long-term solar activity reconstructions".</strong><strong>(Always quote the paper above when using data)</strong><br>
DOI: 10.6084/m9.figshare.11915946
title: Datapoints

description: Datapoints for figures<br>
DOI: 10.18112/openneuro.ds004952.v1.0.3
title: Novel Reading
DOI: 10.6084/m9.figshare.20296465
title: Additional file 21 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 21: Supplementary table 11.
DOI: 10.6084/m9.figshare.20296390
title: Additional file 9 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 9: Table S7. Western blotting results of miR-22-3p acting on AD cell model.
DOI: 10.6084/m9.figshare.19354028
title: Genome assembly of Floccularia luteovirens

description: The Floccularia luteovirens was collected in Qinghai-Tibet Plateau. Then, sequenced and assembled by us.
DOI: 10.6084/m9.figshare.20296468
title: Additional file 22 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 22: Supplementary table 12.
DOI: 10.6084/m9.figshare.20296447.v1
title: Additional file 17 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 17: Supplementary table 7.
DOI: 10.6084/m9.figshare.20296468.v1
title: Additional file 22 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 22: Supplementary table 12.
DOI: 10.6084/m9.figshare.19767844.v1
title: Additional file 2 of The progression rate of spinocerebellar ataxia type 3 varies with disease stage

description: Additional file 2. ICARS prediction based on expanded ATXN3 CAG repeat length, AOga and duration.
DOI: 10.6084/m9.figshare.12956417.v1
title: Gestational diabetes mellitus is associated with antenatal hypercoagulability and hyperfibrinolysis: a case control study of Chinese women

description: To determine the relationship between gestational diabetes mellitus (GDM) and coagulation/fibrinolysis abnormality in antenatal Chinese women. Case control study: 50 women had GDM and 132 did not (the NGDM group) grouping by the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Maternal plasma biochemistry and previous medical history were collected from perinatal health records. Antenatal coagulation/fibrinolysis activity (CFA) parameters were assessed using thromboelastography and routine CFA parameters, respectively. Univariate and multiple regression analyses were used to evaluate the associations between GDM and CFA parameters. Maternal age, platelet, ALT, ALP, urea nitrogen, and previous history of abortion were taken as the covariables. The women with GDM were significantly older than those without GDM (30.3 vs. 28.6 years, <i>p</i> = .012). Compared with the NGDM group, the GDM group had a significantly higher prevalence of cesarean delivery (56.0 vs. 37.9%, <i>p</i> = .027) and higher values of fibrinogen (FIB; 4.7 vs. 4.3 g/L, <i>p</i> = .001), activated partial thromboplastin time (APTT; 30.9 vs. 29.5 s, <i>p</i> = .010).There were no significant differences in the prevalence of maternal thrombotic events or neonatal events. GDM was significantly associated with higher APTT (<i>β</i> =1.41 s, 95% CI: 0.29–2.53), higher FIB (<i>β</i> = 0.38 g/L, 95% CI: 0.14–0.61), and higher percentage reduction in clot lysis after 30 min (LY30; <i>β</i> = 1.14%, 95% CI: 0.15–2.13) after adjustment for potential confounding factors. GDM is significantly associated with hypercoagulability and hyperfibrinolysis in these antenatal Chinese women.
DOI: 10.6084/m9.figshare.21877598
title: Chalcophile element systematics of Mariana Trough basalts and implications for sulphide saturation evolution of intra-oceanic back-arc magmatic systems

description: Magmatic sulphides largely control the behaviour of chalcophile elements in evolving magmas and also play critical roles in ore-forming processes at convergent plate margins. Magmas at the back-arc spreading centre of Mariana Trough are less affected by slab-derived fluids than Mariana arc basalts. However, whether the evolution of chalcophile elements in Mariana Trough magmas resembles or differs from those in arc magmas is poorly known. Based on the detailed petrological and geochemical studies, we present high-precision analyses of whole-rock chalcophile element (S, Cu, Ag, Re, Pd, Pt, Ru, Ir) contents for a suit of basaltic lavas (n = 15) from the central Mariana Trough. The occurrence of sulphides in high-Mg olivine crystals (Fo<sub>80</sub>) indicates that at least one episode of sulphide saturation occurred during early-stage magmatic evolution. The sulphur contents of most basalts were not significantly affected by degassing processes due to low oxidation state and high hydrostatic pressures. Instead, progressive fractionation of liquid sulphide with magmatic evolution is the dominant process, as reflected by sulphide petrography, the decrease in Cu, Ag, Pd, and Pt contents, and concomitant increase in Cu/Pd ratios (22,500–708,500), as well as nearly constant Cu/Ag (mean of 3137 ± 848, 1s) with decreasing MgO. We attribute early sulphide saturation of Mariana Trough basalts to their generation and evolution under relatively reducing conditions, with the limited effect of slab components. Combined with data from other island arc and back-arc lavas, we further show that the extent of adding slab-derived components, regardless of specific arc and back-arc tectonic settings, are determinants of the sulphide evolution and chalcophile element behaviour in magmatic systems above intra-oceanic subduction zones. Early magmatic sulphide saturation at central Mariana Trough would result in barren magmatic systems that are not suitable for the large-scale Cu-Au mineralization at the seafloor.
DOI: 10.6084/m9.figshare.21877598.v1
title: Chalcophile element systematics of Mariana Trough basalts and implications for sulphide saturation evolution of intra-oceanic back-arc magmatic systems

description: Magmatic sulphides largely control the behaviour of chalcophile elements in evolving magmas and also play critical roles in ore-forming processes at convergent plate margins. Magmas at the back-arc spreading centre of Mariana Trough are less affected by slab-derived fluids than Mariana arc basalts. However, whether the evolution of chalcophile elements in Mariana Trough magmas resembles or differs from those in arc magmas is poorly known. Based on the detailed petrological and geochemical studies, we present high-precision analyses of whole-rock chalcophile element (S, Cu, Ag, Re, Pd, Pt, Ru, Ir) contents for a suit of basaltic lavas (n = 15) from the central Mariana Trough. The occurrence of sulphides in high-Mg olivine crystals (Fo<sub>80</sub>) indicates that at least one episode of sulphide saturation occurred during early-stage magmatic evolution. The sulphur contents of most basalts were not significantly affected by degassing processes due to low oxidation state and high hydrostatic pressures. Instead, progressive fractionation of liquid sulphide with magmatic evolution is the dominant process, as reflected by sulphide petrography, the decrease in Cu, Ag, Pd, and Pt contents, and concomitant increase in Cu/Pd ratios (22,500–708,500), as well as nearly constant Cu/Ag (mean of 3137 ± 848, 1s) with decreasing MgO. We attribute early sulphide saturation of Mariana Trough basalts to their generation and evolution under relatively reducing conditions, with the limited effect of slab components. Combined with data from other island arc and back-arc lavas, we further show that the extent of adding slab-derived components, regardless of specific arc and back-arc tectonic settings, are determinants of the sulphide evolution and chalcophile element behaviour in magmatic systems above intra-oceanic subduction zones. Early magmatic sulphide saturation at central Mariana Trough would result in barren magmatic systems that are not suitable for the large-scale Cu-Au mineralization at the seafloor.
DOI: 10.6084/m9.figshare.20296462
title: Additional file 20 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 20: Supplementary table 10.
DOI: 10.6084/m9.figshare.19767847
title: Additional file 3 of The progression rate of spinocerebellar ataxia type 3 varies with disease stage

description: Additional file 3. ICARS prediction based on expanded ATXN3 CAG repeat length and duration.
DOI: 10.6084/m9.figshare.20296465.v1
title: Additional file 21 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 21: Supplementary table 11.
DOI: 10.6084/m9.figshare.24499174.v1
title: Manuscript.zip

description: It is the manuscript.
DOI: 10.6084/m9.figshare.20296429.v1
title: Additional file 11 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 11: Supplementary table 1.
DOI: 10.6084/m9.figshare.20296444.v1
title: Additional file 16 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 16: Supplementary table 6.
DOI: 10.6084/m9.figshare.20296384
title: Additional file 7 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 7: Table S5. Results of Western blotting of blank group and Aβ modeling group.
DOI: 10.6084/m9.figshare.20296384.v1
title: Additional file 7 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 7: Table S5. Results of Western blotting of blank group and Aβ modeling group.
DOI: 10.6084/m9.figshare.20296390.v1
title: Additional file 9 of MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

description: Additional file 9: Table S7. Western blotting results of miR-22-3p acting on AD cell model.
DOI: 10.6084/m9.figshare.20296453.v1
title: Additional file 19 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 19: Supplementary table 9.
DOI: 10.6084/m9.figshare.20296432
title: Additional file 12 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 12: Supplementary table 2.
DOI: 10.6084/m9.figshare.20296438.v1
title: Additional file 14 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 14: Supplementary table 4.
DOI: 10.6084/m9.figshare.20296453
title: Additional file 19 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 19: Supplementary table 9.
DOI: 10.6084/m9.figshare.20296462.v1
title: Additional file 20 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts

description: Additional file 20: Supplementary table 10.
DOI: 10.6084/m9.figshare.11907930
title: Leaving the fish bowl: the ornamental trade as a global vector for freshwater fish invasions

description: Despite its social and economic benefits, the trade in ornamental species (henceforth, ‘ornamental trade’) has become a major source of non-native fish introductions into freshwater ecosystems. However, the ornamental trade as a vector for introductions of non-native freshwater fishes is not well defined. We developed a framework incorporating elements of the biological invasion process and a typical ornamental fish trade supply chain to fill this gap. Records of non-native ornamental fishes introduced to freshwater environments of Australia, Belgium (Flanders), Canada (British Columbia), China (Guangdong), the Philippines, Poland, Singapore, the United Kingdom (England), and the United States of America (Florida) were reviewed to explore the pervasiveness of these introduced fishes in the wild. These regional case studies confirmed the prominence of the ornamental trade as a global vector for freshwater fish introductions beyond their natural range. Additionally, we examined freshwater fishes associated with the ornamental trade to identify ‘risky’ species that could establish in recipient regions based on climate match. All regions assessed were at risk of new fish introductions via the ornamental trade, with the number of ‘risky’ species ranging from seven to 256. Further, there appears to be taxonomic bias in the freshwater ornamental fish trade, with 74% of the species belonging to just 10 families (of 67). Current prevention and management approaches and associated polices, regulations and legislation on aquatic non-native species within assessed regions fit five general categories: import controls, risk assessment, whitelist, blacklist, and release ban. However, these prevention/management efforts may not be sufficient to reduce the invasion risk associated with the ornamental fish trade. Recommendations including species- and vector-based risk assessments, better recording of species import consignments, increased public education and industry engagement, and early detection and rapid response are discussed in this review.
DOI: 10.6084/m9.figshare.12432197.v1
title: Additional file 1 of Earth microbial co-occurrence network reveals interconnection pattern across microbiomes

description: Data file S1. Dataset of literature validation records.
DOI: 10.6084/m9.figshare.17150824.v1
title: Comprehensive analysis of matrix metalloproteinases and their inhibitors in head and neck squamous cell carcinoma

description: <b>Objective:</b> This study aimed to explore the association of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) with cancer progression and prognosis in head and neck squamous cell carcinoma (HNSCC). <b>Methods:</b> Differentially expressed genes (DEGs) were identified by LIMMA package using R software. The correlation between the expression levels of MMPs and TIMPs in HNSCC cancer samples and adjacent normal tissue samples was performed using Pearson correlation analysis. The Kruskal-Wallis test (H-test) was used to determine the association between the expression level of MMPs/TIMPs and HNSCC clinical stage. The survival result was expressed as a KM curve, and the log-rank test was used for statistical analysis. Lasso regression and multivariate Cox regression analyses were used to examine whether the gene signature based on MMPs and TIMPs was an independent prognostic factor in patients with HNSCC. <b>Results:</b> Among the top 10 most up-regulated genes in HNSCC cancer tissues when compared with normal tissues, six genes belonged to the MMPs. Spearman correlation analysis revealed that only MMP11 and MMP23B were positively correlated with tumor stage. Survival analysis showed that patients with a high expression of MMP14, MMP20, TIMP1, and TIMP4 had a worse prognosis than low expression patients. Additionally, a novel five-gene (MMP3, MMP17, MMP19, MMP24, and TIMP1) signature was constructed and significantly associated with prognosis as an independent prognostic signature. <b>Conclusions:</b> Our data show that the accuracy of a single gene of MMP or TIMP as predictors of progression and prognosis of HNSCC is limited, although some studies have proposed that MMPs act as driving factors for cancer progression. The prediction performance of the five-gene signature prediction model was much better than that of the gene signatures based on every single gene in prognosis prediction.
DOI: 10.6084/m9.figshare.12432209
title: Additional file 2 of Earth microbial co-occurrence network reveals interconnection pattern across microbiomes

description: Data file S2. Dataset of edge frequency.