cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4499090.v1
title: Supplementary Material for: Implementation of an Automated Primary Care Acute Kidney Injury Warning System: A Quantitative and Qualitative Review of 2 Years of Experience

description: <b><i>Background:</i></b> Acute kidney injury (AKI) is often detected late, leading to worse clinical outcomes. In 2012, we pioneered an AKI-alerting system for primary care clinicians (PCCs). We retrospectively analysed the alerts and evaluated PCC satisfaction to assess the feasibility of the system. <b><i>Methods:</i></b> The study used a 2-pronged approach. AKI alerts, generated by an algorithm designed by University College London Hospital biochemistry department between June 2012 and June 2014, were analysed to reveal the demographics and outcomes of each patient generating an alert. Second, a survey was sent to all PCCs assessing awareness and satisfaction with the service. Simple statistical methods were applied (mean, median, SD and interquartile range). <b><i>Results:</i></b> One hundred forty-two alerts were generated, of which 101 were genuine. Generally, the patient demographics, AKI stratification and aetiology were in keeping with the inpatient AKI population. Forty-eight percent of cases were referred to the hospital with a median length of stay of 9.9 days. Three-month mortality was 12%. Among PCCs, there was good awareness of the system with most finding it valuable. The key complaints around the system were to do with lack of knowledge of its existence. <b><i>Conclusions:</i></b> Our evaluation has demonstrated that the implementation of AKI alerts in the community is technically feasible, does not result in excessive demand on hospital services, appears to influence PCC behaviour and was perceived overwhelmingly as a useful service by these clinicians. This experience should inform further developments including behavioural interventions (such as clinician alerts) to improve community AKI care.
DOI: 10.6084/m9.figshare.4499075
title: Supplementary Material for: Increase of Mast Cell-Nerve Association and Neuropeptide Receptor Expression on Mast Cells in Perennial Allergic Rhinitis

description: <b><i>Objectives:</i></b> Mast cells (MCs) and nerves play an important role in allergic rhinitis (AR), but little is known about their crosstalk in AR. The aim of this study was to investigate MC-nerve interaction in the human nasal mucosa during AR. <b><i>Methods:</i></b> The association between MCs and nerves, the expression of neuropeptide receptors (neurokinin 1 receptor [NK1R], neurokinin 2 receptor [NK2R], calcitonin gene-related peptide receptor [CGRPR], and MrgX2) on MCs, and protease-activated receptor 2 (PAR2) and tyrosine receptor kinase A (TrkA) on nerve fibres in the human nasal mucosa were investigated with immunofluorescence and real-time PCR. <b><i>Results:</i></b> The association between MCs and nerves was found to be significantly increased, although the numbers of MCs and nerve fibres were unchanged during AR. MCs expressing tryptase-chymase (MC<sub>tc</sub>) were frequently associated with nerve fibres and these contacts increased significantly in AR. Neuropeptide receptors NK1R, NK2R, and CGRPR were firstly found to be largely localised on MCs. The number of MCs expressing NK1R and NK2R, but not CGRPR, was significantly increased in AR. Interestingly, MC<sub>tc</sub> mostly expressed these neuropeptide receptors. The newly discovered tachykinin receptor MrgX2 was not expressed on nasal MCs, but was expressed on gland cells and increased in AR. Additionally, tachykinergic nerve fibres were found to express PAR2 or TrkA as receptors for MCs. <b><i>Conclusions:</i></b> This study revealed for the first time an increase of MC-nerve association and neuropeptide receptor expression on MCs during AR as well as nerve fibres containing receptors for MCs. These results suggest that targeting or controlling airway sensory nerve function as a modulator of MCs may prevent allergic airway inflammation such as AR.
DOI: 10.6084/m9.figshare.4499075.v1
title: Supplementary Material for: Increase of Mast Cell-Nerve Association and Neuropeptide Receptor Expression on Mast Cells in Perennial Allergic Rhinitis

description: <b><i>Objectives:</i></b> Mast cells (MCs) and nerves play an important role in allergic rhinitis (AR), but little is known about their crosstalk in AR. The aim of this study was to investigate MC-nerve interaction in the human nasal mucosa during AR. <b><i>Methods:</i></b> The association between MCs and nerves, the expression of neuropeptide receptors (neurokinin 1 receptor [NK1R], neurokinin 2 receptor [NK2R], calcitonin gene-related peptide receptor [CGRPR], and MrgX2) on MCs, and protease-activated receptor 2 (PAR2) and tyrosine receptor kinase A (TrkA) on nerve fibres in the human nasal mucosa were investigated with immunofluorescence and real-time PCR. <b><i>Results:</i></b> The association between MCs and nerves was found to be significantly increased, although the numbers of MCs and nerve fibres were unchanged during AR. MCs expressing tryptase-chymase (MC<sub>tc</sub>) were frequently associated with nerve fibres and these contacts increased significantly in AR. Neuropeptide receptors NK1R, NK2R, and CGRPR were firstly found to be largely localised on MCs. The number of MCs expressing NK1R and NK2R, but not CGRPR, was significantly increased in AR. Interestingly, MC<sub>tc</sub> mostly expressed these neuropeptide receptors. The newly discovered tachykinin receptor MrgX2 was not expressed on nasal MCs, but was expressed on gland cells and increased in AR. Additionally, tachykinergic nerve fibres were found to express PAR2 or TrkA as receptors for MCs. <b><i>Conclusions:</i></b> This study revealed for the first time an increase of MC-nerve association and neuropeptide receptor expression on MCs during AR as well as nerve fibres containing receptors for MCs. These results suggest that targeting or controlling airway sensory nerve function as a modulator of MCs may prevent allergic airway inflammation such as AR.
DOI: 10.5281/zenodo.4012253
title: Ontolex-lemon and TIAD versions of Apertium Welsh-English dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2005-2009, Kevin Donnelly 2007-2008, Generalitat de Catalunya (dades anglés) 2007-2010, Jim O'Regan 2007-2014, Francis M. Tyers 2007, Liamtomkins 2009, Pminervini 2010-2014, Kevin Brubeck Unhammer 2012, Anthony J. Bentley
DOI: 10.6084/m9.figshare.4499015
title: Oasis_150-data.xlsx

description: This spreadsheet has the ID we used in OASIS database and the four measures we processed (sulcal measures, cortical thickness, cortical volume and subcortical volume). The authors confirm that all data related to the findings reported in the paper are fully available without restriction. The scans used in the research can be freely accessed via OASIS website (http://www.oasis-brains.org).
DOI: 10.6084/m9.figshare.4499036.v1
title: ELC V123 ELC platforms.csv

description: Dataset of Platforms of Electronic Literature Collections
DOI: 10.5281/zenodo.4012252
title: Ontolex-lemon and TIAD versions of Apertium Welsh-English dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2005-2009, Kevin Donnelly 2007-2008, Generalitat de Catalunya (dades anglés) 2007-2010, Jim O'Regan 2007-2014, Francis M. Tyers 2007, Liamtomkins 2009, Pminervini 2010-2014, Kevin Brubeck Unhammer 2012, Anthony J. Bentley
DOI: 10.6084/m9.figshare.4499009
title: New draft item

description: food science<br>
DOI: 10.6084/m9.figshare.4499003
title: The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

description: Type II testicular germ cell cancers (TGCT) are the most frequently diagnosed tumours in young men (20–40 years) and are classified as seminoma or non-seminoma. TGCTs are commonly treated by orchiectomy and chemo- or radiotherapy. However, a subset of metastatic non-seminomas (embryonal carcinomas) displays only incomplete remission or relapse and requires novel treatment options. Recent studies have shown effective application of the small-molecule inhibitor JQ1 in tumour therapy, which interferes with the function of ‘bromodomain and extraterminal (BET)’ proteins. JQ1-treated TGCT cell lines display up-regulation of genes indicative for DNA damage and cellular stress response and induce cell cycle arrest. Embryonal carcinoma (EC) cell lines, which presented as JQ1 sensitive, display down-regulation of pluripotency factors and induction of mesodermal differentiation. In contrast, seminoma-like TCam-2 cells tolerated higher JQ1 concentrations and were resistant to differentiation. ECs xenografted <em>in vivo</em> showed a reduction in tumour size, proliferation rate and angiogenesis in response to JQ1. Finally, the combination of JQ1 and the histone deacetylase inhibitor romidepsin allowed for lower doses and less frequent application, compared with monotherapy. Thus, we propose that JQ1 in combination with romidepsin may serve as a novel therapeutic option for (mixed) TGCTs.
DOI: 10.6084/m9.figshare.4499009.v1
title: New draft item

description: food science<br>
DOI: 10.6084/m9.figshare.4499036.v3
title: ELC V123 ELC platforms.csv

description: Dataset of Platforms of Electronic Literature Collections
DOI: 10.6084/m9.figshare.4498982
title: Data File; Text file containing all participant data from The confusion effect when attacking simulated three-dimensional starling flocks

description: The confusion effect describes the phenomenon of decreasing predator attack success with increasing prey group size. However, there is a paucity of research into the influence of this effect in coherent groups, such as flocks of European starlings (<i>Sturnus vulgaris</i>). Here, for the first time, we use a computer game style experiment to investigate the confusion effect in three dimensions. To date, computerized studies on the confusion effect have used two-dimensional simulations with simplistic prey movement and dynamics. Our experiment is the first investigation of the effects of flock size and density on the ability of a (human) predator to track and capture a target starling in a realistically simulated three-dimensional flock of starlings. In line with the predictions of the confusion effect, modelled starlings appear to be safer from predation in larger and denser flocks. This finding lends credence to previous suggestions that starling flocks have anti-predator benefits and, more generally, it suggests that active increases in density in animal groups in response to predation may increase the effectiveness of the confusion effect.
DOI: 10.6084/m9.figshare.4498982.v1
title: Data File; Text file containing all participant data from The confusion effect when attacking simulated three-dimensional starling flocks

description: The confusion effect describes the phenomenon of decreasing predator attack success with increasing prey group size. However, there is a paucity of research into the influence of this effect in coherent groups, such as flocks of European starlings (<i>Sturnus vulgaris</i>). Here, for the first time, we use a computer game style experiment to investigate the confusion effect in three dimensions. To date, computerized studies on the confusion effect have used two-dimensional simulations with simplistic prey movement and dynamics. Our experiment is the first investigation of the effects of flock size and density on the ability of a (human) predator to track and capture a target starling in a realistically simulated three-dimensional flock of starlings. In line with the predictions of the confusion effect, modelled starlings appear to be safer from predation in larger and denser flocks. This finding lends credence to previous suggestions that starling flocks have anti-predator benefits and, more generally, it suggests that active increases in density in animal groups in response to predation may increase the effectiveness of the confusion effect.
DOI: 10.6084/m9.figshare.4498958
title: Raw data files from The control of translational accuracy is a determinant of healthy ageing in yeast

description: Raw data in excel format, including luciferase assay, ageing and growth rate data.
DOI: 10.6084/m9.figshare.4498958.v1
title: Raw data files from The control of translational accuracy is a determinant of healthy ageing in yeast

description: Raw data in excel format, including luciferase assay, ageing and growth rate data.
DOI: 10.6084/m9.figshare.4498940
title: Puttick_et_al_R_script from Uncertain-tree: discriminating among competing approaches to the phylogenetic analysis of phenotype data

description: The R script used to generate the simulated data on which this analysis was based
DOI: 10.5281/zenodo.4012246
title: Ontolex-lemon and TIAD versions of Apertium Crimean Tatar-Turkish dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2017, Memduh Gökırmak 2017, Francis M. Tyers 2017, Ilnar Salimzyan
DOI: 10.6084/m9.figshare.4498940.v1
title: Puttick_et_al_R_script from Uncertain-tree: discriminating among competing approaches to the phylogenetic analysis of phenotype data

description: The R script used to generate the simulated data on which this analysis was based
DOI: 10.5281/zenodo.4012245
title: Ontolex-lemon and TIAD versions of Apertium Crimean Tatar-Turkish dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2017, Memduh Gökırmak 2017, Francis M. Tyers 2017, Ilnar Salimzyan
DOI: 10.6084/m9.figshare.4498922
title: Data supporting the article from Corticosterone and timing of migratory departure in a songbird

description: Bird migration entails replenishing fuel stores at stopover sites. There, individuals make daily decisions whether to resume migration, and must also decide their time of departure. Variation in departure timing affects the total time required to complete a migratory journey, which in turn affects fitness through arrival time at the breeding and wintering grounds. It is well established that stopover departure decisions are based on cues from innate rhythms, intrinsic factors and extrinsic factors. Yet, virtually nothing is known about the physiological mechanism(s) linking these cues to departure decisions. Here, we show for a nocturnal migratory songbird, the northern wheatear (<i>Oenanthe oenanthe</i>), that baseline corticosterone levels of birds at stopover increased both over the migratory season and with wind assistance towards the migratory destination. Corticosterone in turn predicted departure probability; individuals with high baseline corticosterone levels were more likely to resume migration on a given night. Corticosterone further predicted the departure time within the night, with high baseline levels being associated with early departures. These novel findings indicate that corticosterone may be mediating between departure cues and the timing of departure from a stopover site, which is a major step towards understanding the hormonal control of animal migration
DOI: 10.6084/m9.figshare.4498916
title: Mean differences between sets of residuals and permutation test probabilities of the differences from How do great bowerbirds construct perspective illusions?

description: Many animals build structures to provide shelter, avoid predation, attract mates or house offspring, but the behaviour and potential cognitive processes involved during building are poorly understood. Great bowerbird (<i>Ptilinorhynchus nuchalis</i>) males build and maintain display courts by placing tens to hundreds of objects in a positive size–distance gradient. The visual angles created by the gradient create a forced perspective illusion that females can use to choose a mate. Although the quality of illusion is consistent within males, it varies among males, which may reflect differences in how individuals reconstruct their courts. We moved all objects off display courts to determine how males reconstructed the visual illusion. We found that all individuals rapidly created the positive size–distance gradient required for forced perspective within the first 10 objects placed. Males began court reconstruction by placing objects in the centre of the court and then placing objects further out, a technique commonly used when humans lay mosaics. The number of objects present after 72 h was not related to mating success or the quality of the illusion, indicating that male skill at arranging objects rather than absolute number of objects appears to be important. We conclude that differences arise in the quality of forced perspective illusions despite males using the same technique to reconstruct their courts.
DOI: 10.6084/m9.figshare.4498910
title: A neonatal bimodal MR-CT head template

description: In this paper, we present an approach to create a fully registered bimodal MR-CT head template for neonates with a gestational age of 39 to 42 weeks. Such a template is essential for structural and functional brain studies, which require precise geometry of the head including cranial bones and fontanels-sutures. Due to the special characteristics of the problem (which requires inter-subject inter-modality registration), a two-step intensity-based registration method is proposed to globally and locally align CT images with an available MR template. By applying groupwise registration, the new neonatal CT template is then created in full alignment with the MR template to build a bimodal MR-CT template.<br>The uploaded data include the neonatal bi-modal MR-CT template (GRAMFC_T39-42.nii and GRAMFC_CT39-42.nii) and 10 CT images (Test1.nii ~ Test10.nii) used for evaluation corresponding to the results reported in Table 2 of the article.<br>
DOI: 10.6084/m9.figshare.4498922.v1
title: Data supporting the article from Corticosterone and timing of migratory departure in a songbird

description: Bird migration entails replenishing fuel stores at stopover sites. There, individuals make daily decisions whether to resume migration, and must also decide their time of departure. Variation in departure timing affects the total time required to complete a migratory journey, which in turn affects fitness through arrival time at the breeding and wintering grounds. It is well established that stopover departure decisions are based on cues from innate rhythms, intrinsic factors and extrinsic factors. Yet, virtually nothing is known about the physiological mechanism(s) linking these cues to departure decisions. Here, we show for a nocturnal migratory songbird, the northern wheatear (<i>Oenanthe oenanthe</i>), that baseline corticosterone levels of birds at stopover increased both over the migratory season and with wind assistance towards the migratory destination. Corticosterone in turn predicted departure probability; individuals with high baseline corticosterone levels were more likely to resume migration on a given night. Corticosterone further predicted the departure time within the night, with high baseline levels being associated with early departures. These novel findings indicate that corticosterone may be mediating between departure cues and the timing of departure from a stopover site, which is a major step towards understanding the hormonal control of animal migration
DOI: 10.6084/m9.figshare.4498916.v1
title: Mean differences between sets of residuals and permutation test probabilities of the differences from How do great bowerbirds construct perspective illusions?

description: Many animals build structures to provide shelter, avoid predation, attract mates or house offspring, but the behaviour and potential cognitive processes involved during building are poorly understood. Great bowerbird (<i>Ptilinorhynchus nuchalis</i>) males build and maintain display courts by placing tens to hundreds of objects in a positive size–distance gradient. The visual angles created by the gradient create a forced perspective illusion that females can use to choose a mate. Although the quality of illusion is consistent within males, it varies among males, which may reflect differences in how individuals reconstruct their courts. We moved all objects off display courts to determine how males reconstructed the visual illusion. We found that all individuals rapidly created the positive size–distance gradient required for forced perspective within the first 10 objects placed. Males began court reconstruction by placing objects in the centre of the court and then placing objects further out, a technique commonly used when humans lay mosaics. The number of objects present after 72 h was not related to mating success or the quality of the illusion, indicating that male skill at arranging objects rather than absolute number of objects appears to be important. We conclude that differences arise in the quality of forced perspective illusions despite males using the same technique to reconstruct their courts.
DOI: 10.6084/m9.figshare.4498907
title: A summary of sequencing quality of data archived in Sequence Read Archive

description: Quality information of sequencing data archived in Sequence Read Archive calculated by FastQC
DOI: 10.6084/m9.figshare.4498715
title: Potter Cove food web (Antarctica): details on trophic species and interactions.

description: This is the supplementary data of the article "Potter Cove food web: complexity, structure and function". We constructed the FW of Potter Cove ecosystem (25 de mayo/King George Is., Antarctica) based primarily upon information about species living in that system and their feeding habits from studies within the framework of an international research cooperation between Argentina and Germany initiated in 1994 and continued for more than 20 years. We collected the information on feeding links by a thorough literature search (&gt; 500 papers and reports revised). To assemble the network we only considered trophic interactions confirmed by gut content studies and/or field observation.
DOI: 10.6084/m9.figshare.4498730
title: Linking potential biodiversity and three ecosystem services in silvopastoral managed forest landscapes of Tierra del Fuego, Argentina

description: Several studies confirm that biodiversity loss endangers ecosystem services (ES) supply and human well-being. A better understanding of biodiversity–ES relationships and effects of biodiversity loss on ES supply is needed. The objective was to determine relationships between potential biodiversity and three ES in Patagonia where cattle ranching under silvopastoral use occurs. We used grids of potential biodiversity (plant species richness) and three ES, provisioning (cattle stocking rate), regulating (CO<sub>2</sub> sequestration) and cultural (geo-tagged digital-images). Potential biodiversity was negatively related to provisioning, but no significant relations were detected with regulating and cultural. These relations showed regional differences related to forest landscape distribution. High values of regulating were found in southern areas being coincident with high potential biodiversity. Opposite trends (negative relationship with biodiversity) was observed for provisioning in eastern and western regions where provisioning decrease from N-S. Results suggest that provisioning do not overlap spatially with the higher values of potential biodiversity maps, which is an advantage for land use planning when conservation and management requirements must be combined. Our results are the first contribution for Patagonia to underpin scientific and institutional efforts to connect biodiversity conservation with ES maintenance. However, further studies must be addressed including more ES and regions.<b>EDITED BY</b> Sandra Luque <b>EDITED BY</b> Sandra Luque