cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21942/uva.21904932
title: Results

description: In this folder you can find the behavioral data and JASP files of both behavior and EEG to compute the statistics reported in the paper. The behavioral data of this folder can be loaded with the script "all_figures_PLOSBIO23.m" (see scripts).
DOI: 10.21942/uva.21904932.v1
title: Results

description: In this folder you can find the behavioral data and JASP files of both behavior and EEG to compute the statistics reported in the paper. The behavioral data of this folder can be loaded with the script "all_figures_PLOSBIO23.m" (see scripts).
DOI: 10.6084/m9.figshare.21857076.v1
title: Perception and attitude towards online clinical modules: A Cross-sectional study among medical students from 2 countries

description: DATA set for creating a repository for the article <strong>Perception and attitude towards online clinical modules: A Cross-sectional study among medical students from 2 countries</strong>
DOI: 10.34740/kaggle/dsv/4863512
title: YouTube Daily
DOI: 10.6084/m9.figshare.21694814
title: Supplementary Material for: Increased expression levels of soluble fms-like tyrosine kinase-1 inhibits the development of the nervous system

description: Introduction: Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity. At present, only limited options are available for the treatments of preeclampsia. Consequently, many patients need to terminate their pregnancy to relieve the disease. Soluble fms-like tyrosine kinase-1 (sFlt-1) is a decoy receptor of placental growth factor (PIGF) and vascular endothelial growth factor (VEGF) which can promote angiogenesis. Throughout pregnancy, the expression level of sFlt-1 continues to increase in both the mother with PE and her offspring. Material and methods: In this experiment, we generated a zebrafish line expressing high levels of sFlt-1 and investigated changes in behavior and development of the nervous system. Results: At 96 hours post-fertilization (hpf), the brain volume area of zebrafish in the experimental group (zFLT1+CasRx) was significantly smaller after injection than in the WT group (P&lt;0.05) and the negative control group (CasRx) (P&lt;0.05). At 96 hpf, compared with the WT group, the cerebral blood vessels in the CasRx control group and experimental group (zFLT1-sgRNA+CasRx) were significantly lower after injection (P&lt;0.05). Compared with the CasRx control group, the track movement distance, and the mean track speed of zebrafish in the experimental group (zFLT1-sgRNA+CasRx) after the 6th injection were significantly decreased (P&lt;0.05). Conclusions: the increased expression levels of sFlt-1 in zebrafish inhibited the development of the cerebral blood vessels, influenced brain volumes, and inhibited behavioral activities. Our data suggest that the elevation of sFlt-1 in the pathological state of PE can inhibit the development of the nervous system in offspring.
DOI: 10.6084/m9.figshare.21694814.v1
title: Supplementary Material for: Increased expression levels of soluble fms-like tyrosine kinase-1 inhibits the development of the nervous system

description: Introduction: Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity. At present, only limited options are available for the treatments of preeclampsia. Consequently, many patients need to terminate their pregnancy to relieve the disease. Soluble fms-like tyrosine kinase-1 (sFlt-1) is a decoy receptor of placental growth factor (PIGF) and vascular endothelial growth factor (VEGF) which can promote angiogenesis. Throughout pregnancy, the expression level of sFlt-1 continues to increase in both the mother with PE and her offspring. Material and methods: In this experiment, we generated a zebrafish line expressing high levels of sFlt-1 and investigated changes in behavior and development of the nervous system. Results: At 96 hours post-fertilization (hpf), the brain volume area of zebrafish in the experimental group (zFLT1+CasRx) was significantly smaller after injection than in the WT group (P&lt;0.05) and the negative control group (CasRx) (P&lt;0.05). At 96 hpf, compared with the WT group, the cerebral blood vessels in the CasRx control group and experimental group (zFLT1-sgRNA+CasRx) were significantly lower after injection (P&lt;0.05). Compared with the CasRx control group, the track movement distance, and the mean track speed of zebrafish in the experimental group (zFLT1-sgRNA+CasRx) after the 6th injection were significantly decreased (P&lt;0.05). Conclusions: the increased expression levels of sFlt-1 in zebrafish inhibited the development of the cerebral blood vessels, influenced brain volumes, and inhibited behavioral activities. Our data suggest that the elevation of sFlt-1 in the pathological state of PE can inhibit the development of the nervous system in offspring.
DOI: 10.48329/mb3e-vy82
title: CPRD GOLD Pregnancy Register May 2022

description: The CPRD GOLD Pregnancy Register is derived from the primary care data and contains a list of all pregnancy episodes within the CPRD GOLD database, approximately 7 million pregnancies. 

The CPRD GOLD Pregnancy Register is developed using an algorithm and contains a number of data variables including the start and end of pregnancy, trimester dates and the outcome of the pregnancy.

Access is subject to fees and an approved study protocol. Further information is available at https://cprd.com/cprd-linked-data
DOI: 10.48329/v6z9-j580
title: CPRD Aurum Pregnancy Register May 2022

description: The CPRD Aurum Pregnancy Register is derived from the primary care data and contains a list of all pregnancy episodes within the CPRD Aurum database, approximately 17 million pregnancies. 

The CPRD Aurum Pregnancy Register is developed using an algorithm and contains a number of data variables including the start and end of pregnancy, trimester dates and the outcome of the pregnancy.

Access is subject to fees and an approved study protocol. Further information is available at https://cprd.com/cprd-linked-data
DOI: 10.6084/m9.figshare.19739718
title: A systematic literature review of evidence for the use of assistive exoskeletons in defence and security use cases

description: Advances in assistive exoskeleton technology, and a boom in related scientific literature, prompted a need to review the potential use of exoskeletons in defence and security. A systematic review examined the evidence for successful augmentation of human performance in activities deemed most relevant to military tasks. Categories of activities were determined <i>a priori</i> through literature scoping and Human Factors workshops with military stakeholders. Workshops identified promising opportunities and risks for integration of exoskeletons into military use cases. The review revealed promising evidence for exoskeletons’ capacity to assist with load carriage, manual lifting, and working with tools. However, the review also revealed significant gaps in exoskeleton capabilities and likely performance levels required in the use case scenarios. Consequently, it was recommended that a future roadmap for introducing exoskeletons to military environments requires development of performance criteria for exoskeletons that can be used to implement a human-centred approach to research and development. We assessed the state-of-the-art for the use of wearable assistive exoskeletons in UK defence and security use cases. A full systematic review of the literature was undertaken, informed by use cases developed in military stakeholder workshops. Clear gaps in exoskeleton capability and use case requirements were identified, leading to recommendations for future work.
DOI: 10.6084/m9.figshare.19739718.v1
title: A systematic literature review of evidence for the use of assistive exoskeletons in defence and security use cases

description: Advances in assistive exoskeleton technology, and a boom in related scientific literature, prompted a need to review the potential use of exoskeletons in defence and security. A systematic review examined the evidence for successful augmentation of human performance in activities deemed most relevant to military tasks. Categories of activities were determined <i>a priori</i> through literature scoping and Human Factors workshops with military stakeholders. Workshops identified promising opportunities and risks for integration of exoskeletons into military use cases. The review revealed promising evidence for exoskeletons’ capacity to assist with load carriage, manual lifting, and working with tools. However, the review also revealed significant gaps in exoskeleton capabilities and likely performance levels required in the use case scenarios. Consequently, it was recommended that a future roadmap for introducing exoskeletons to military environments requires development of performance criteria for exoskeletons that can be used to implement a human-centred approach to research and development. We assessed the state-of-the-art for the use of wearable assistive exoskeletons in UK defence and security use cases. A full systematic review of the literature was undertaken, informed by use cases developed in military stakeholder workshops. Clear gaps in exoskeleton capability and use case requirements were identified, leading to recommendations for future work.
DOI: 10.34740/kaggle/dsv/4863530
title: Global Genomic Neurofibromatosis Neoplasia
DOI: 10.5258/soton/d2502
title: Dataset in support of the Southampton doctoral thesis 'Flow Photochemical Routes to Indoles and 8-membered Lactones, and their Application in Target Synthesis'

description: This file includes NMR data for all compounds seen in the thesis experimental, collected using NMR machines in B29, University of Southampton (use ACDLabs to view). It also includes IR data, collected on IR machine in B30, University of Southampton (Use ACDLabs to view). Also included is HRMS data collected by the MS department, B30, University of Southampton.
DOI: 10.5519/qd.ilz8zdgu
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.5281/zenodo.7533466
title: Infiltration and soil moisture Saugraben and Weiherbach experimental sites

description: <em>Infiltration experiments at Saugraben infiltration experimental site and measured and modelled soil moisture at Weiherbach hydrological experimental catchment</em>
description: PWAB-Programme, Baden-Württemberg State Germany [Saugraben]; BMBF, Germany [Weiherbach-Project]
DOI: 10.5281/zenodo.7533465
title: Infiltration and soil moisture Saugraben and Weiherbach experimental sites

description: <em>Infiltration experiments at Saugraben infiltration experimental site and measured and modelled soil moisture at Weiherbach hydrological experimental catchment</em>
description: PWAB-Programme, Baden-Württemberg State Germany [Saugraben]; BMBF, Germany [Weiherbach-Project]
DOI: 10.5519/qd.tchb9ymq
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (60 records)
DOI: 10.6084/m9.figshare.21908445
title: Additional file 1

description: Additional file 1
DOI: 10.6084/m9.figshare.21908445.v1
title: Additional file 1

description: Additional file 1
DOI: 10.6084/m9.figshare.17149208.v12
title: CRISPR/Cas12a-based assay for the rapid and high-sensitivity detection of Streptococcus agalactiae colonization in pregnant women with premature rupture of membrane.xlsx

description: <strong>Background: </strong><em>Streptococcus agalactiae</em> or group B <em>Streptococcus</em> (GBS) is a leading infectious cause of neonatal morbidity and mortality. It is essential to establish a robust method for the rapid and ultra-sensitive detection of GBS in pregnant women with premature rupture of membrane (PROM). <strong>Methods: </strong>This study developed a CRISPR-GBS assay that combined the advantages of the recombinase polymerase amplification (RPA) and CRISPR/Cas12a system for GBS detection. The clinical performance of the CRISPR-GBS assay was assessed using vaginal or cervical swabs that were collected from 179 pregnant women with PROM, compared in parallel to culture-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry (culture-MS) method and real-time quantitative polymerase chain reaction (qPCR) assay. <strong>Results:</strong> The CRISPR-GBS assay can be completed within 35 minutes and the limit of detection was as low as 5 copies μL<sup>-1</sup>. Compared with the culture-MS, the CRISPR-GBS assay demonstrated a sensitivity of 96.64% (144/149, 95% confidence interval [CI] = 92.39–98.56%) and a specificity of 100% (30/30, 95% CI = 88.65–100%). It also had a high concordance rate of 98.88% with the qPCR assay. <strong>Conclusions:</strong> The established CRISPR-GBS platform can detect GBS in a rapid, accurate, easy-to-operate, and cost-efficient manner. It offered a promising tool for the intrapartum screening of GBS colonization.
DOI: 10.6084/m9.figshare.17149208.v11
title: CRISPR/Cas12a-based assay for the rapid and high-sensitivity detection of Streptococcus agalactiae colonization in pregnant women with premature rupture of membrane.xlsx

description: <strong>Background: </strong><em>Streptococcus agalactiae</em> or group B <em>Streptococcus</em> (GBS) is a leading infectious cause of neonatal morbidity and mortality. It is essential to establish a robust method for the rapid and ultra-sensitive detection of GBS in pregnant women with premature rupture of membrane (PROM). <strong>Methods: </strong>This study developed a CRISPR-GBS assay that combined the advantages of the recombinase polymerase amplification (RPA) and CRISPR/Cas12a system for GBS detection. The clinical performance of the CRISPR-GBS assay was assessed using vaginal or cervical swabs that were collected from 179 pregnant women with PROM, compared in parallel to culture-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry (culture-MS) method and real-time quantitative polymerase chain reaction (qPCR) assay. <strong>Results:</strong> The CRISPR-GBS assay can be completed within 35 minutes and the limit of detection was as low as 5 copies μL<sup>-1</sup>. Compared with the culture-MS, the CRISPR-GBS assay demonstrated a sensitivity of 96.64% (144/149, 95% confidence interval [CI] = 92.39–98.56%) and a specificity of 100% (30/30, 95% CI = 88.65–100%). It also had a high concordance rate of 98.88% with the qPCR assay. <strong>Conclusions:</strong> The established CRISPR-GBS platform can detect GBS in a rapid, accurate, easy-to-operate, and cost-efficient manner. It offered a promising tool for the intrapartum screening of GBS colonization.
DOI: 10.6084/m9.figshare.21908495
title: Predicting the <i>in vitro</i> dissolution rate constant of mineral wool fibers from fiber composition

description: We developed predictive formulae for the <i>in vitro</i> dissolution rate constant k<sub>dis</sub> of acid-soluble synthetic vitreous fibers (SVF), paralleling our earlier work with glass wools, which are typically more soluble at neutral pH. Developing simple models for predicting the k<sub>dis</sub> of a fiber can allow prediction of <i>in vivo</i> behavior, aid fiber developers, and potentially reduce <i>in vivo</i> testing. The k<sub>dis</sub> of several acid-soluble SVF were determined using high simulant fluid flow/fiber surface area (F/A) conditions <i>via</i> a single-fiber measurement system. Four fluids were employed, varying in base composition and citrate levels. Equations predicting the k<sub>dis</sub> were derived from fiber chemistry and dissolution measurements for two of the fluids. Testing of several fibers showed a ∼10× increase in the k<sub>dis</sub> when citrate was included in the simulant solution. Data from tests with Stefaniak’s citrate-free Phagoloysosmal Simulant Fluid (PSF) yielded k<sub>dis</sub> values aligned with expectations from <i>in vivo</i> results, unlike results from citrate-containing modified Gamble’s solution. Predictive equations relating fiber chemistry to k<sub>dis</sub> showed reasonable agreement between the measured and predicted values. Citrate inclusion in the solution under high F/A conditions significantly increased the measured k<sub>dis</sub>. This resulted in more biorelevant data being obtained using the PSF fluid with the high F/A method used. The developed predictive equations, sufficient for fiber development work, require refinement before a recommending their use in place of <i>in vivo</i> biopersistence testing. Significant fit improvements are possible through additional measurements under these experimental conditions.
DOI: 10.6084/m9.figshare.21908495.v1
title: Predicting the <i>in vitro</i> dissolution rate constant of mineral wool fibers from fiber composition

description: We developed predictive formulae for the <i>in vitro</i> dissolution rate constant k<sub>dis</sub> of acid-soluble synthetic vitreous fibers (SVF), paralleling our earlier work with glass wools, which are typically more soluble at neutral pH. Developing simple models for predicting the k<sub>dis</sub> of a fiber can allow prediction of <i>in vivo</i> behavior, aid fiber developers, and potentially reduce <i>in vivo</i> testing. The k<sub>dis</sub> of several acid-soluble SVF were determined using high simulant fluid flow/fiber surface area (F/A) conditions <i>via</i> a single-fiber measurement system. Four fluids were employed, varying in base composition and citrate levels. Equations predicting the k<sub>dis</sub> were derived from fiber chemistry and dissolution measurements for two of the fluids. Testing of several fibers showed a ∼10× increase in the k<sub>dis</sub> when citrate was included in the simulant solution. Data from tests with Stefaniak’s citrate-free Phagoloysosmal Simulant Fluid (PSF) yielded k<sub>dis</sub> values aligned with expectations from <i>in vivo</i> results, unlike results from citrate-containing modified Gamble’s solution. Predictive equations relating fiber chemistry to k<sub>dis</sub> showed reasonable agreement between the measured and predicted values. Citrate inclusion in the solution under high F/A conditions significantly increased the measured k<sub>dis</sub>. This resulted in more biorelevant data being obtained using the PSF fluid with the high F/A method used. The developed predictive equations, sufficient for fiber development work, require refinement before a recommending their use in place of <i>in vivo</i> biopersistence testing. Significant fit improvements are possible through additional measurements under these experimental conditions.
DOI: 10.6084/m9.figshare.21828547
title: Dataset from The island biogeography of human population size

description: For decades, biogeographers have sought a better understanding of how organisms are distributed among islands. However, the island biogeography of humans remains largely unknown. Here, we investigate how human population size varies among 486 islands at two spatial scales. At a global scale, we tested whether population size increases with island area and declines with island elevation and nearest mainland, as is common in non-human species, or whether humans escape such biogeographic constraints. At a regional scale, we tested whether population sizes vary among islands within archipelagos according to the positioning of different cultural source pools. Results illustrate that on a global scale, human populations increased in size with island area, similar to non-human species, yet they did not decline in size with elevation and distance to nearest mainland. At a regional scale, human population size often varied among islands within archipelagos relative to the location of different cultural source pools. Despite broad-scale similarities in the geographical distribution of human and non-human species among islands, results from this study indicate that the island biogeography of humans may also be influenced by archipelago-specific social, political and historical circumstances.
DOI: 10.6084/m9.figshare.21828553
title: Code from The island biogeography of human population size

description: For decades, biogeographers have sought a better understanding of how organisms are distributed among islands. However, the island biogeography of humans remains largely unknown. Here, we investigate how human population size varies among 486 islands at two spatial scales. At a global scale, we tested whether population size increases with island area and declines with island elevation and nearest mainland, as is common in non-human species, or whether humans escape such biogeographic constraints. At a regional scale, we tested whether population sizes vary among islands within archipelagos according to the positioning of different cultural source pools. Results illustrate that on a global scale, human populations increased in size with island area, similar to non-human species, yet they did not decline in size with elevation and distance to nearest mainland. At a regional scale, human population size often varied among islands within archipelagos relative to the location of different cultural source pools. Despite broad-scale similarities in the geographical distribution of human and non-human species among islands, results from this study indicate that the island biogeography of humans may also be influenced by archipelago-specific social, political and historical circumstances.
DOI: 10.6084/m9.figshare.21828553.v2
title: Code from The island biogeography of human population size

description: For decades, biogeographers have sought a better understanding of how organisms are distributed among islands. However, the island biogeography of humans remains largely unknown. Here, we investigate how human population size varies among 486 islands at two spatial scales. At a global scale, we tested whether population size increases with island area and declines with island elevation and nearest mainland, as is common in non-human species, or whether humans escape such biogeographic constraints. At a regional scale, we tested whether population sizes vary among islands within archipelagos according to the positioning of different cultural source pools. Results illustrate that on a global scale, human populations increased in size with island area, similar to non-human species, yet they did not decline in size with elevation and distance to nearest mainland. At a regional scale, human population size often varied among islands within archipelagos relative to the location of different cultural source pools. Despite broad-scale similarities in the geographical distribution of human and non-human species among islands, results from this study indicate that the island biogeography of humans may also be influenced by archipelago-specific social, political and historical circumstances.
DOI: 10.6084/m9.figshare.21828547.v1
title: Dataset from The island biogeography of human population size

description: For decades, biogeographers have sought a better understanding of how organisms are distributed among islands. However, the island biogeography of humans remains largely unknown. Here, we investigate how human population size varies among 486 islands at two spatial scales. At a global scale, we tested whether population size increases with island area and declines with island elevation and nearest mainland, as is common in non-human species, or whether humans escape such biogeographic constraints. At a regional scale, we tested whether population sizes vary among islands within archipelagos according to the positioning of different cultural source pools. Results illustrate that on a global scale, human populations increased in size with island area, similar to non-human species, yet they did not decline in size with elevation and distance to nearest mainland. At a regional scale, human population size often varied among islands within archipelagos relative to the location of different cultural source pools. Despite broad-scale similarities in the geographical distribution of human and non-human species among islands, results from this study indicate that the island biogeography of humans may also be influenced by archipelago-specific social, political and historical circumstances.