cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.969662.v1
title: Mobility Analysis of 2 nm to 11 nm Aerosol Particles with an Aspirating Drift Tube Ion Mobility Spectrometer

description: We describe the performance of a drift tube-ion mobility spectrometry (DT-IMS) instrument for the measurement of aerosol particles. In DT-IMS, the electrical mobility of a measured particle is inferred directly from the time required for the particle to traverse a drift region, with motion driven by an electrostatic field. Electrical mobility distributions are hence linked to arrival time distributions (ATDs) for particles reaching a detector downstream of the drift region. The developed instrument addresses two obstacles that have limited DT-IMS use for aerosol measurement previously: (1) conventional drift tubes cannot efficiently sample charged particles at ground potential and (2) the sensitivities of commonly used Faraday plate detectors are too low for most aerosols. Obstacle (1) is circumvented by creating a “sample volume” of aerosol for measurement, defined by the streamlines of fluid flow. Obstacle (2) is bypassed by interfacing the end of the drift region with a condensation particle counter. The DT-IMS prototype shows high linearity for arrival time versus inverse electrical mobility (<i>R</i><sup>2</sup> &gt; 0.99) over the size range tested (2.2–11.1 nm), and measurements compare well with both analytical and numerical models of device performance. A dimensionless calibration curve linking drift time to inverse electrical mobility is developed. In less than 5 s, it is possible to measure 11.1 nm particles, while 2.2 nm particles are analyzable on a subsecond scale. The transmission efficiency is found to be dependent upon electrostatic deposition for short drift times and upon advective losses for long drift times. Copyright 2014 American Association for Aerosol Research
DOI: 10.6084/m9.figshare.969654
title: Exocytosis micrograph dump

description: Batch of exocytotic micrographs,Phosphotungstic acid/Osmium and PTA/glutaraldehyde fixative
DOI: 10.6084/m9.figshare.969654.v1
title: Exocytosis micrograph dump

description: Batch of exocytotic micrographs,Phosphotungstic acid/Osmium and PTA/glutaraldehyde fixative
DOI: 10.6084/m9.figshare.969640
title: Structural basis of <i>Bacillus anthracis</i> MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

description: <i>Bacillus anthracis</i> MoxXT is a Type II proteic Toxin–Antitoxin (TA) module wherein MoxT is a ribonuclease that cleaves RNA specifically while MoxX interacts with MoxT and inhibits its activity. Disruption of the TA interaction has been proposed as a novel antibacterial strategy. Peptides, either based on antitoxin sequence or rationally designed, have previously been reported to disrupt the MoxXT interaction but cause a decrease in MoxT ribonuclease activity. In the present study, we report the crystal structure of MoxT, and the effect of several peptides in disrupting the MoxXT interaction as well as augmentation of MoxT ribonuclease activity by binding to MoxT <i>in vitro</i>. Docking studies on the peptides were carried out in order to explain the observed structure activity relationships. The peptides with ribonuclease augmentation activity possess a distinct structure and are proposed to bind to a distinct site on MoxT. The docking of the active peptides with MoxT showed that they possess an aromatic group that occupies a conserved hydrophobic pocket. Additionally, the peptides inducing high ribonuclease activity were anchored by a negatively charged group near a cluster of positively charged residues present near the pocket. Our study provides a structural basis and rationale for the observed properties of the peptides and may aid the development of small molecules to disrupt the TA interaction.
DOI: 10.6084/m9.figshare.969640.v2
title: Structural basis of <i>Bacillus anthracis</i> MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

description: <i>Bacillus anthracis</i> MoxXT is a Type II proteic Toxin–Antitoxin (TA) module wherein MoxT is a ribonuclease that cleaves RNA specifically while MoxX interacts with MoxT and inhibits its activity. Disruption of the TA interaction has been proposed as a novel antibacterial strategy. Peptides, either based on antitoxin sequence or rationally designed, have previously been reported to disrupt the MoxXT interaction but cause a decrease in MoxT ribonuclease activity. In the present study, we report the crystal structure of MoxT, and the effect of several peptides in disrupting the MoxXT interaction as well as augmentation of MoxT ribonuclease activity by binding to MoxT <i>in vitro</i>. Docking studies on the peptides were carried out in order to explain the observed structure activity relationships. The peptides with ribonuclease augmentation activity possess a distinct structure and are proposed to bind to a distinct site on MoxT. The docking of the active peptides with MoxT showed that they possess an aromatic group that occupies a conserved hydrophobic pocket. Additionally, the peptides inducing high ribonuclease activity were anchored by a negatively charged group near a cluster of positively charged residues present near the pocket. Our study provides a structural basis and rationale for the observed properties of the peptides and may aid the development of small molecules to disrupt the TA interaction.
DOI: 10.6084/m9.figshare.969640.v1
title: Structural basis of <i>Bacillus anthracis</i> MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

description: <i>Bacillus anthracis</i> MoxXT is a Type II proteic Toxin–Antitoxin (TA) module wherein MoxT is a ribonuclease that cleaves RNA specifically while MoxX interacts with MoxT and inhibits its activity. Disruption of the TA interaction has been proposed as a novel antibacterial strategy. Peptides, either based on antitoxin sequence or rationally designed, have previously been reported to disrupt the MoxXT interaction but cause a decrease in MoxT ribonuclease activity. In the present study, we report the crystal structure of MoxT, and the effect of several peptides in disrupting the MoxXT interaction as well as augmentation of MoxT ribonuclease activity by binding to MoxT <i>in vitro</i>. Docking studies on the peptides were carried out in order to explain the observed structure activity relationships. The peptides with ribonuclease augmentation activity possess a distinct structure and are proposed to bind to a distinct site on MoxT. The docking of the active peptides with MoxT showed that they possess an aromatic group that occupies a conserved hydrophobic pocket. Additionally, the peptides inducing high ribonuclease activity were anchored by a negatively charged group near a cluster of positively charged residues present near the pocket. Our study provides a structural basis and rationale for the observed properties of the peptides and may aid the development of small molecules to disrupt the TA interaction.
DOI: 10.6084/m9.figshare.969633
title: Simple method to measure cell-free circulating DNA

description: A direct fluorometric degradation assay using PicoGreen was performed to quantify cell-free DNA from patient plasma.
DOI: 10.6084/m9.figshare.969632
title: One-step concentration of malarial parasite-infected red blood cells and removal of contaminating white blood cells

description: How to isolate malaria parasite? Using magnetic device, we can concentrate malarial parasite-infected red blood cells and remove contaminating white blood cells.
DOI: 10.6084/m9.figshare.969633.v1
title: Simple method to measure cell-free circulating DNA

description: A direct fluorometric degradation assay using PicoGreen was performed to quantify cell-free DNA from patient plasma.
DOI: 10.6084/m9.figshare.969632.v1
title: One-step concentration of malarial parasite-infected red blood cells and removal of contaminating white blood cells

description: How to isolate malaria parasite? Using magnetic device, we can concentrate malarial parasite-infected red blood cells and remove contaminating white blood cells.
DOI: 10.6084/m9.figshare.967996
title: Elevated CO2 effects on minerals in wheat grains (2002)

description: The data show the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn and Mn in wheat grains (% change). The data are for <br>Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 <br>TREE opinion pieces did not allow to include supporting data at the time of publication. The data are published here to allow to reproduce any of the results of the study, Fig. 1 (wheat grain/yellow bars).
DOI: 10.6084/m9.figshare.967997
title: Elevated CO2 effects on minerals in foliar tissues (2002)

description: These are data showing the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn, Mn, Cl, Cu, B, Na, Si, Mo, and Al in folliar tissues (% change). The data are for Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 TREE opinion pieces did not allow to include supporting data. The data are pubhlished here and support Fig. 1 (foliar/green bars).
DOI: 10.6084/m9.figshare.12921941
title: P16INK4a expression in patients with penile cancer

description: Background<br>Infection with human papillomavirus (HPV) is reported to be present in 30–50% of penile cancer cases. The immunohistochemical test for p16<sup>INK4a</sup> is used as an indicator of the presence of HPV and as a prognostic marker for squamous cell carcinomas in various sites. However, the role of this marker in penile carcinoma has not yet been completely elucidated. The aim of this study was to analyze whether the expression of p16<sup>INK4a</sup> is associated with the presence of HPV, histological parameters, and survival in penile cancer.<br>Methods<br>A study was conducted from 2014 to 2016 that included 55 patients with penile carcinoma. HPV DNA was detected through PCR using fresh tumor tissue, and immunohistochemistry was performed for analysis of p16<sup>INK4a</sup> protein using paraffin-embedded tissue. Evaluation of histological parameters was performed following complete embedding of the tumor tissue in paraffin.<br>Results<br>HPV DNA (low-risk and high-risk genotypes) was found in 49 (89.1%) cases, and 46/49 (93.9%) showed high-oncogenic risk HPV (HR-HPV). Of the 22 cases positive for p16<sup>INK4a</sup>, HR-HPV DNA was present in 21 (95.5%) (p = 0.032). Regarding histological parameters, p16<sup>INK4a</sup> and HR-HPV were significantly associated only with tumor subtype (p = 0.036 and p = 0.032, respectively); all carcinomas with basaloid characteristics were positive for p16<sup>INK4a</sup>. Although HPV+ patients had a higher disease-free survival (p &lt;0.001), p16<sup>INK4a</sup> expression was not associated with patient survival.<br>Conclusions<br>Our study, using fresh tissue samples, showed the highest incidence of HPV compared to that observed in the literature. Expression of the p16<sup>INK4a</sup> protein was significantly associated with the presence of HR-HPV and this expression may serve as a marker for the presence of the virus. The p16<sup>INK4a</sup> protein was not associated with the histological prognostic parameters, with the exception of tumor subtype, nor with patient survival. In the results, we showed that the objective of the present study was reached.
DOI: 10.6084/m9.figshare.967996.v2
title: Elevated CO2 effects on minerals in wheat grains (2002)

description: The data show the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn and Mn in wheat grains (% change). The data are for <br>Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 <br>TREE opinion pieces did not allow to include supporting data at the time of publication. The data are published here to allow to reproduce any of the results of the study, Fig. 1 (wheat grain/yellow bars).
DOI: 10.6084/m9.figshare.967997.v2
title: Elevated CO2 effects on minerals in foliar tissues.

description: These are data showing the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn, Mn, Cl, Cu, B, Na, Si, Mo, and Al in folliar tissues (% change). The data are for Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 TREE opinion pieces did not allow any inclusion of data. Thus, no data were included with the 2002 paper. These data support Fig. 1 (foliar/green bars).
DOI: 10.6084/m9.figshare.967996.v1
title: Elevated CO2 effects on minerals in wheat grains

description: The data show the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn and Mn in wheat grains (% change). The data are for <br>Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 <br>TREE opinion pieces did not allow to include supporting data. The data are published here and support Fig. 1 (wheat grain/yellow bars).
DOI: 10.6084/m9.figshare.967997.v4
title: Elevated CO2 effects on minerals in foliar tissues (2002)

description: These are data showing the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn, Mn, Cl, Cu, B, Na, Si, Mo, and Al in folliar tissues (% change). The data are for Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 TREE opinion pieces did not allow to include supporting data. The data are pubhlished here and support Fig. 1 (foliar/green bars).
DOI: 10.6084/m9.figshare.967938
title: Study1a

description: Study 1a data
DOI: 10.6084/m9.figshare.967940
title: Study2

description: Study 2 data
DOI: 10.6084/m9.figshare.967939
title: Study1b

description: Study 1b data
DOI: 10.6084/m9.figshare.967939.v1
title: Study1b

description: Study 1b data
DOI: 10.6084/m9.figshare.967997.v3
title: Elevated CO2 effects on minerals in foliar tissues

description: These are data showing the effect of doubling CO2 concentrations on C, N, P, K, Ca, S, Mg, Fe, Zn, Mn, Cl, Cu, B, Na, Si, Mo, and Al in folliar tissues (% change). The data are for Loladze (2002) Rising atmospheric CO2 and human nutrition: toward globally imbalanced plant stoichiometry? Trends in Ecology & Evolution (TREE) 17:457-461 TREE opinion pieces did not allow to include supporting data. The data are pubhlished here and support Fig. 1 (foliar/green bars).
DOI: 10.6084/m9.figshare.967892
title: „Zarządzanie wartością i ryzykiem przedsiębiorstwa na przykładzie: przedsiębiorstwa produkującego wyroby z metalu, organizacji non profit świadczącej usługi przeciwpożarowe oraz instytucji finansowej z zakresu Otwartych Funduszy Emerytalnych.”

description: A way of managing the goodwill on the example of the enterprise producing products from metal,<br>non-profit organization providing fire services, financial institutions from the scope is reporting back<br>of Open pension funds. Calculations were conducted at using the method Eva. all data for calculations<br>was taken from financial statements of chosen business entities.
DOI: 10.6084/m9.figshare.967938.v1
title: Study1a

description: Study 1a data
DOI: 10.6084/m9.figshare.967940.v1
title: Study2

description: Study 2 data
DOI: 10.6084/m9.figshare.967878
title: ZWRP Praca Grupowa E

description: Zarządzanie Wartością i Ryzykiem Przedsiębiorstwa Praca Grupowa E
DOI: 10.6084/m9.figshare.967892.v1
title: „Zarządzanie wartością i ryzykiem przedsiębiorstwa na przykładzie: przedsiębiorstwa produkującego wyroby z metalu, organizacji non profit świadczącej usługi przeciwpożarowe oraz instytucji finansowej z zakresu Otwartych Funduszy Emerytalnych.”

description: A way of managing the goodwill on the example of the enterprise producing products from metal,<br>non-profit organization providing fire services, financial institutions from the scope is reporting back<br>of Open pension funds. Calculations were conducted at using the method Eva. all data for calculations<br>was taken from financial statements of chosen business entities.
DOI: 10.6084/m9.figshare.967878.v1
title: ZWRP Praca Grupowa E

description: Zarządzanie Wartością i Ryzykiem Przedsiębiorstwa Praca Grupowa E
DOI: 10.6084/m9.figshare.967862
title: Zarządzanie wartością i ryzykiem przedsiębiorstwa

description: Przedstawiany raport ukazuje podstawowe zagadnienia dotyczące zarządzania wartością i ryzykiem w organizacjach: nonprofit, instytucji finansowej i w przedsiębiorstwie „X” z branży produkcji metali. Przeprowadzona analiza zarządzania opiera się na średnim ważonym koszcie kapitału oraz na przeanalizowaniu wpływu na wzrost wartości przedsiębiorstwa. Do obliczeń zostały wykorzystane sprawozdania finansowe z lat 2009,2010,2011 a także wywiad diagnostyczny przeprowadzony z przedstawicielem przedsiębiorstwa.
DOI: 10.6084/m9.figshare.967864
title: Refleksje na temat pracy „Zarządzanie wartością i ryzykiem w przedsiębiorstwie, instytucji finansowej oraz organizacji non-profit.” autorstwa: T. Banasik, Ł. Demidowicz, I. Teppel, A. Wolska.

description: Projects subject is risk management in three types of organisations: a company, financial institution and non-profit organisation. The authors explains how important is even a cursory risk assessment in our after-crisis-environment.
DOI: 10.6084/m9.figshare.967862.v1
title: Zarządzanie wartością i ryzykiem przedsiębiorstwa

description: Przedstawiany raport ukazuje podstawowe zagadnienia dotyczące zarządzania wartością i ryzykiem w organizacjach: nonprofit, instytucji finansowej i w przedsiębiorstwie „X” z branży produkcji metali. Przeprowadzona analiza zarządzania opiera się na średnim ważonym koszcie kapitału oraz na przeanalizowaniu wpływu na wzrost wartości przedsiębiorstwa. Do obliczeń zostały wykorzystane sprawozdania finansowe z lat 2009,2010,2011 a także wywiad diagnostyczny przeprowadzony z przedstawicielem przedsiębiorstwa.
DOI: 10.6084/m9.figshare.967863
title: Zarządzanie Wartością i Ryzykiem

description: Przedstawiany raport ukazuje podstawowe zagadnienia dotyczące zarządzania wartością i ryzykiem w organizacjach: nonprofit, instytucji finansowej i w przedsiębiorstwie „X” z branży produkcji metali. Przeprowadzona analiza zarządzania opiera się na średnim ważonym koszcie kapitału oraz na przeanalizowaniu wpływu na wzrost wartości przedsiębiorstwa. Do obliczeń zostały wykorzystane sprawozdania finansowe z lat 2009,2010,2011 a także wywiad diagnostyczny przeprowadzony z przedstawicielem przedsiębiorstwa.
DOI: 10.6084/m9.figshare.967864.v1
title: Refleksje na temat pracy „Zarządzanie wartością i ryzykiem w przedsiębiorstwie, instytucji finansowej oraz organizacji non-profit.” autorstwa: T. Banasik, Ł. Demidowicz, I. Teppel, A. Wolska.

description: Projects subject is risk management in three types of organisations: a company, financial institution and non-profit organisation. The authors explains how important is even a cursory risk assessment in our after-crisis-environment.
DOI: 10.6084/m9.figshare.967858
title: Zarządzanie wartością przedsiębiorstwa na przykładzie organizacji X,Y,Z.

description: Celem niniejszej pracy jest analiza odpowiednich wskaźników trzech jednostek w celu oceny zarządzania wartością przedsiębiorstw. Wybrane podmioty to organizacja nonprofit, instytucja finansowa oraz przedsiębiorstwo nie będące organizacją nonprofit lub instytucją finansową. Dane potrzebne do oceny instytucji pochodzą ze sprawozdań finansowych z lat 2009 – 2011.
DOI: 10.6084/m9.figshare.967863.v1
title: Zarządzanie Wartością i Ryzykiem

description: Przedstawiany raport ukazuje podstawowe zagadnienia dotyczące zarządzania wartością i ryzykiem w organizacjach: nonprofit, instytucji finansowej i w przedsiębiorstwie „X” z branży produkcji metali. Przeprowadzona analiza zarządzania opiera się na średnim ważonym koszcie kapitału oraz na przeanalizowaniu wpływu na wzrost wartości przedsiębiorstwa. Do obliczeń zostały wykorzystane sprawozdania finansowe z lat 2009,2010,2011 a także wywiad diagnostyczny przeprowadzony z przedstawicielem przedsiębiorstwa.
DOI: 10.6084/m9.figshare.967844
title: CAU talk

description: Talk at CAU in Beijing
DOI: 10.6084/m9.figshare.967844.v1
title: CAU talk

description: Talk at CAU in Beijing
DOI: 10.6084/m9.figshare.967827
title: Data set of primary outcome changes in interventional clinical trials registered on ClinicalTrials.org

description: All clinical studies classified as ‘interventional studies’ registered with ClinicalTrials as of 25 October 2012 are shown. The following information was collected from each study: study registration date; the study start date; the primary completion date; study completion date; original primary outcome and date submitted; current primary outcome and date submitted; study phase, data monitoring committee; study sponsor and collaborators.
DOI: 10.6084/m9.figshare.967827.v1
title: Data set of primary outcome changes in interventional clinical trials registered on ClinicalTrials.org

description: All clinical studies classified as ‘interventional studies’ registered with ClinicalTrials as of 25 October 2012 are shown. The following information was collected from each study: study registration date; the study start date; the primary completion date; study completion date; original primary outcome and date submitted; current primary outcome and date submitted; study phase, data monitoring committee; study sponsor and collaborators.
DOI: 10.6084/m9.figshare.966666
title: Cloud hosted APIs for cheminformatics on mobile devices (ACS Dallas 2014)

description: Mobile apps for cheminformatics are quite powerful on their own, but can be significantly boosted by connecting them with cloud-hosted functionality. This talk explores the range of functionality that can be covered simply by making use of apps with stateless webservices, i.e. anonymous access without persistent data.
DOI: 10.6084/m9.figshare.966666.v1
title: Cloud hosted APIs for cheminformatics on mobile devices (ACS Dallas 2014)

description: Mobile apps for cheminformatics are quite powerful on their own, but can be significantly boosted by connecting them with cloud-hosted functionality. This talk explores the range of functionality that can be covered simply by making use of apps with stateless webservices, i.e. anonymous access without persistent data.
DOI: 10.6084/m9.figshare.966642
title: Disulfur Dichloride Transition State ClSSCl to ClS(Cl)=S

description: This file shows the transition state between ClSSCl and ClS(Cl)=S at the wB97X-D/6-31+G(d,p) level of theory.
DOI: 10.6084/m9.figshare.966620
title: Recenzja pracy grupowej: N. Hauder, J. Jadach, P. Jankowska, M. Jeż, M. Jonczyk, p.t. "Zarządanie wartością przedsiębiorstwa na przykładzie organizacji X, Y, Z"

description: Recenzja pracy grupowej: N. Hauder, J. Jadach, P. Jankowska, M. Jeż, M. Jonczyk p.t. "Zarządzanie wartością przedsiębiorstwa na przykładzie organizacji X, Y, Z"
DOI: 10.6084/m9.figshare.966640
title: Recenzja pracy Zarządzanie wartością w organizacji non profit, instytucji finansowej, przedsiębiorstwie

description: Recenzja pracy, w której dokonano pomiaru oraz przeanalizowano wartość przedsiębiorstw należących do trzech sektorów: non profit, finansowego oraz niebędącego organizacją non profit i finansową.
DOI: 10.6084/m9.figshare.966642.v1
title: Disulfur Dichloride Transition State ClSSCl to ClS(Cl)=S

description: This file shows the transition state between ClSSCl and ClS(Cl)=S at the wB97X-D/6-31+G(d,p) level of theory.