cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc24v7lv
title: CCDC 1991427: Experimental Crystal Structure Determination

description: Related Article: Pauline Chaumont-Olive, Janine Cossy|2020|Org.Lett.|22|3870|doi:10.1021/acs.orglett.0c01114
DOI: 10.5517/ccdc.csd.cc24vqlb
title: CCDC 1991892: Experimental Crystal Structure Determination

description: Related Article: Joseph T. Musongong, Mathew E. Otang, Brandon L. Mash, Matthias Zeller, Lothar Stahl|2020|Dalton Trans.|49|6341|doi:10.1039/D0DT01163K
DOI: 10.34740/kaggle/ds/631004
title: Dataset Metadata for CORD-19
DOI: 10.34740/kaggle/dsv/1101935
title: Bangladesh District Level COVID-19 Dataset
DOI: 10.5517/ccdc.csd.cc1npt5b
title: CCDC 1540302: Experimental Crystal Structure Determination

description: Related Article: Dawei Wang, Tao Wang, Ping Zhao, Zhengjun Shi, Qihua Zhao|2020|Inorg.Chim.Acta|508|119657|doi:10.1016/j.ica.2020.119657
DOI: 10.5517/ccdc.csd.cc202cp5
title: CCDC 1849326: Experimental Crystal Structure Determination

description: Related Article: Marcel Mirel Popa, Sergiu Shova, Madalina Hrubaru, Loredana Barbu, Constantin Draghici, Florea Dumitrascu, Denisa E. Dumitrescu|2020|RSC Advances|10|15656|doi:10.1039/D0RA02368J
DOI: 10.5517/ccdc.csd.cc21v457
title: CCDC 1901948: Experimental Crystal Structure Determination

description: Related Article: Qianqian Yang, Yijie Wang, Yanxue Shang, Juan Du, Jianbo Yin, Di Liu, Zixi Kang, Rongming Wang, Daofeng Sun, Jianzhuang Jiang|2020|Cryst.Growth Des.|20|3456|doi:10.1021/acs.cgd.0c00235
DOI: 10.5517/ccdc.csd.cc249lrt
title: CCDC 1975436: Experimental Crystal Structure Determination

description: Related Article: Resul Sevinçek, Muhittin Aygün, Yüksel Şahin|2020|J.Mol.Struct.|1217|128321|doi:10.1016/j.molstruc.2020.128321
DOI: 10.5517/ccdc.csd.cc24cqmw
title: CCDC 1977478: Experimental Crystal Structure Determination

description: Related Article: Vı́ctor Augusto Moreno-Martínez, Diego Martı́nez-Otero, Brandon Meza-González, Fernando Cortéz-Guzmán, Vojtech Jancik|2020|Inorg.Chem.|59|6849|doi:10.1021/acs.inorgchem.0c00224
DOI: 10.5517/ccdc.csd.cc24dc86
title: CCDC 1978087: Experimental Crystal Structure Determination

description: Related Article: Samuel I. Jacob, Iskander Douair, Guang Wu, Laurent Maron, Gabriel Ménard|2020|Chem.Commun.|56|8182|doi:10.1039/D0CC01699C
DOI: 10.5517/ccdc.csd.cc24g62x
title: CCDC 1979848: Experimental Crystal Structure Determination

description: Related Article: Raphael Koch, Yu Sun, Andreas Orthaber, Antonio J. Pierik, Frank Pammer|2020|Org.Chem.Front.|7|1437|doi:10.1039/D0QO00267D
DOI: 10.5517/ccdc.csd.cc24gj38
title: CCDC 1980159: Experimental Crystal Structure Determination

description: Related Article: Matteo Savastano, Carla Bazzicalupi, Antonio Bianchi|2020|Chem.-Eur.J.|26|5994|doi:10.1002/chem.202000505
DOI: 10.5517/ccdc.csd.cc24gnt3
title: CCDC 1980305: Experimental Crystal Structure Determination

description: Related Article: Alejandro Carnero, Virginia Martín-Nieves, Yogesh S. Sanghvi, Olivia O. Russel, Leda Bassit, Raymond F. Schinazi, Susana Fernández and Miguel Ferrero|2020|RSC Advances|10|15815|doi:10.1039/D0RA03254A
DOI: 10.5517/ccdc.csd.cc24gsr5
title: CCDC 1980427: Experimental Crystal Structure Determination

description: Related Article: Simon Budde, Felix Goerdeler, Johannes Floß, Peter Kreitmeier, Elliot F. Hicks, Oren Moscovitz, Peter H. Seeberger, Huw M. L. Davies, Oliver Reiser|2020|Org.Chem.Front.|7|1789|doi:10.1039/D0QO00168F
DOI: 10.5517/ccdc.csd.cc24gtn3
title: CCDC 1980455: Experimental Crystal Structure Determination

description: Related Article: Raquel Giménez, Olga Crespo, Beatriz Diosdado, Anabel Elduque|2020|J.Mater.Chem.C|8|6552|doi:10.1039/D0TC00642D
DOI: 10.5517/ccdc.csd.cc24h08y
title: CCDC 1980629: Experimental Crystal Structure Determination

description: Related Article: Francisco Fueyo-González, Emilio Garcia-Fernandez, David Martínez, Lourdes Infantes, Angel Orte, Juan A. González-Vera, Rosario Herranz|2020|Chem.Commun.|56|5484|doi:10.1039/D0CC01725F
DOI: 10.5517/ccdc.csd.cc24j371
title: CCDC 1981682: Experimental Crystal Structure Determination

description: Related Article: Andreas W. Kyri, Lukas Schuh, Andreas Knoechl, Michael Schalli, Ana Torvisco, Roland C. Fischer, Michael Haas, Harald Stueger|2020|Organometallics|39|1832|doi:10.1021/acs.organomet.0c00106
DOI: 10.5517/ccdc.csd.cc24kpfv
title: CCDC 1983207: Experimental Crystal Structure Determination

description: Related Article: Beatrice Berti,  Marco Bortoluzzi,  Cristiana Cesari,  Cristina Femoni,  Maria Carmela Iapalucci,  Rita Mazzoni,  Stefano Zacchini|2020|Eur.J.Inorg.Chem.|2020|2191|doi:10.1002/ejic.202000260
DOI: 10.5517/ccdc.csd.cc24xqtm
title: CCDC 1993821: Experimental Crystal Structure Determination

description: Related Article: Reece G. Miller, Mark R. Warren, David R. Allan, Sally Brooker|2020|Inorg.Chem.|59|6376|doi:10.1021/acs.inorgchem.0c00471
DOI: 10.5517/ccdc.csd.cc2557tf
title: CCDC 2001044: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Russell P. Hughes|2020|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc1zrq9r
title: CCDC 1840045: Experimental Crystal Structure Determination

description: Related Article: Arif I. Inamdar, Abhishek Pathak, Muhammad Usman, Kuan-Ru Chiou, Pei-Hsien Tsai, Shruti Mendiratta, Saqib Kamal, Yen-Hsiang Liu, Jenq-Wei Chen, Ming-Hsi Chiang, Kuang-Lieh Lu|2020|J.Mater.Chem.A|8|11958|doi:10.1039/D0TA00605J
DOI: 10.5517/ccdc.csd.cc1zrt7s
title: CCDC 1840136: Experimental Crystal Structure Determination

description: Related Article: Thasanaporn Ungpittagul, Phonpimon Wongmahasirikun, Khamphee Phomphrai|2020|Dalton Trans.|49|8460|doi:10.1039/D0DT01115K
DOI: 10.5517/ccdc.csd.cc230cvc
title: CCDC 1936782: Experimental Crystal Structure Determination

description: Related Article: Cong Xu, Yu Feng, Li-Ren Wang, Wen-Peng Ma, Yan-Mei He, Qing-Hua Fan|2020|Organometallics|39|1945|doi:10.1021/acs.organomet.0c00141
DOI: 10.5517/ccdc.csd.cc230dzj
title: CCDC 1936817: Experimental Crystal Structure Determination

description: Related Article: Cong Xu, Yu Feng, Li-Ren Wang, Wen-Peng Ma, Yan-Mei He, Qing-Hua Fan|2020|Organometallics|39|1945|doi:10.1021/acs.organomet.0c00141
DOI: 10.5517/ccdc.csd.cc233zt1
title: CCDC 1940253: Experimental Crystal Structure Determination

description: Related Article: Ruirui Wang, Haili Wang, Juan Wang, Feifei Bai, Yue Ma, Licun Li, Qinglun Wang, Bin Zhao, Peng Cheng|2020|CrystEngComm|22|2998|doi:10.1039/D0CE00039F
DOI: 10.5517/ccdc.csd.cc245l42
title: CCDC 1971573: Experimental Crystal Structure Determination

description: Related Article: Andrzej Nowok, Piotr Kuś, Mateusz Dulski, Joachim Kusz, Maria Książek, Maciej Zubko, Anna Z. Szeremeta, Sebastian Pawlus|2020|CrystEngComm|22|3164|doi:10.1039/D0CE00351D
DOI: 10.5517/ccdc.csd.cc245lgd
title: CCDC 1971583: Experimental Crystal Structure Determination

description: Related Article: Steven J. Dakermanji, Karl S. Westendorff, Emmit K. Pert, Katy B. Wilson, Jeffery T. Myers, Justin H. Wilde, Diane A. Dickie, Kevin D. Welch, W. Dean Harman|2020|Organometallics|39|1961|doi:10.1021/acs.organomet.0c00151
DOI: 10.5517/ccdc.csd.cc246z9n
title: CCDC 1972911: Experimental Crystal Structure Determination

description: Related Article: He Yang,  Jiawei Sun,  Wei Gu,  Wenjun Tang|2020|J.Am.Chem.Soc.|142|8036|doi:10.1021/jacs.0c02686
DOI: 10.5517/ccdc.csd.cc24d7wp
title: CCDC 1977982: Experimental Crystal Structure Determination

description: Related Article: Elena A. Malinina, Svetlana E. Korolenko, Aleksey S. Kubasov, Lyudmila V. Goeva, Varvara V. Avdeeva, Nikolay T. Kuznetsov|2020|Polyhedron|184|114566|doi:10.1016/j.poly.2020.114566
DOI: 10.5517/ccdc.csd.cc24dc75
title: CCDC 1978086: Experimental Crystal Structure Determination

description: Related Article: Samuel I. Jacob, Iskander Douair, Guang Wu, Laurent Maron, Gabriel Ménard|2020|Chem.Commun.|56|8182|doi:10.1039/D0CC01699C
DOI: 10.5517/ccdc.csd.cc24g61w
title: CCDC 1979847: Experimental Crystal Structure Determination

description: Related Article: Raphael Koch, Yu Sun, Andreas Orthaber, Antonio J. Pierik, Frank Pammer|2020|Org.Chem.Front.|7|1437|doi:10.1039/D0QO00267D
DOI: 10.5517/ccdc.csd.cc24h0c1
title: CCDC 1980632: Experimental Crystal Structure Determination

description: Related Article: Ricardo G. Teixeira, Fernanda Marques, M. Paula Robalo, Xavier Fontrodona, M. Helena Garcia, Simonetta Geninatti Crich, Clara Viñas, Andreia Valente|2020|RSC Advances|10|16266|doi:10.1039/D0RA01522A
DOI: 10.5258/soton/d0422
title: Dataset supporting an article "Amplified O-band WDM Transmission using a Bi-doped Fibre Amplifier"

description: This dataset supports:
N. Taengnoi et al., "Amplified O-Band WDM Transmission Using a Bi-Doped Fibre Amplifier," 2018 European Conference on Optical Communication (ECOC), Rome, Italy, 2018, pp. 1-3, doi: 10.1109/ECOC.2018.8535369.

The data demonstrate WDM transmission on both a coarse and dense spacing over 100km and 120km of SMF-28e, respectively, using mid-span amplification with a Bismuth-doped fibre amplifier exhibiting 7THz (42nm) of gain bandwidth. Negligible power penalties were observed for all signals.

The data for each figure is contained within a directory of the same name in Excel files. Data files are named after the Figure they correspond to and contain the data necessary to recreate the plots.

The data is accessible under CC BY license
DOI: 10.6084/m9.figshare.16807766.v1
title: Additional file 2 of Developing an efficient DNA barcoding system to differentiate between Lilium species

description: Table S2. Information about tested Lilium species in this study.
DOI: 10.6084/m9.figshare.16807712
title: Additional file 7 of PbLAC4-like, activated by PbMYB26, related to the degradation of anthocyanin during color fading in pear

description: Additional file 7: Table S3. Sequences of primers used for vector construction.
DOI: 10.6084/m9.figshare.25151492.v1
title: Appendices to IAWA 2275

description: <b>Appendix I.</b> Data matrix used for cluster analysis, with the characteristics of the woods of <i>Handroanthus barbatus</i>, H<i>. capitatus</i>, <i>H. </i><i>impetiginosus</i>, <i>H. incanus</i> and<i> H. serratifolius. </i>1 = presence, 0 = absence.<b>Appendix II</b>. Data matrix used for cluster analysis, with morphological characteristics of the leaves of <i>Handroanthus impetiginosus</i> and <i>H. serratifolius. 1 </i>= presence, 0 = absence.<b>Appendix III</b>. Data matrix used for cluster analysis, with the anatomical characteristics of the wood and morphological characteristics of the leaves of <i>Handroanthus impetiginosus</i> and <i>H. serratifolius.</i> 1 = presence, 0 = absence.
DOI: 10.6084/m9.figshare.16807537.v1
title: Additional file 2 of SWATH-MS based quantitive proteomics reveal regulatory metabolism and networks of androdioecy breeding system in Osmanthus fragrans

description: Additional file 2: Table S2. Functional classification of DEPs with the MapMAN BIN system.
DOI: 10.6084/m9.figshare.19953686
title: Marine invertebrate fossils from the Permian–Triassic boundary beds of two core sections in the northern Perth Basin, Western Australia

description: Marine macroinvertebrate fossils from two petroleum exploration cores, Apium-1 and Redback-2, are described, and found to contain two separate assemblages. The assemblage from the Apium-1 core was recovered from an <i>ca</i> 5-m-thick interval (2756.35–2751.28 m) in the basal Hovea Member (‘inertinitic interval’) of the Kockatea Shale and includes the following forms: ?<i>Spinomarginifera</i> sp., <i>Cimmeriella</i> sp., ?<i>Etherilosia</i> sp., <i>Elivina</i> sp., <i>Cleiothyridina</i> sp., and Paeckelmanelloidea gen. et. sp. indet. (all brachiopods). The age of this assemblage is interpreted as Changhsingian, as constrained by its association with the palynofloral <i>Dulhuntyispora parvithola</i> Zone. The assemblage from the Redback-2 core was recovered from the ‘sapropelic interval’ of the Hovea Member of the Kockatea Shale between 3806 m and 3786 m and comprises the following forms: Lingulidae gen. et sp. indet. (brachiopod), <i>Claraia perthensis</i> Dickins & McTavish, <i>Crittendenia</i> cf. <i>australasiatica</i> (Krumbeck), ?<i>Paralledon</i> sp. (bivalves), ?<i>Otoceras</i> sp. (ammonoid), <i>Microconchus utahensis</i> Zatoń, Taylor & Vinn (microconchid) and <i>Magniestheria mangaliensis</i> (Jones) (spinicaudatan). Among these, the first local appearances of the lingulid species, ?<i>Otoceras</i> sp. and <i>M. mangaliensis</i> are associated with the palynofloral <i>Protohaploxypinus microcorpus</i> Zone and are interpreted as latest Changhsingian in age. Other occurrences of the Redback-2 fossil assemblage overlap with the palynofloral <i>Kraeuselisporites saeptatus</i> Zone and are considered to be of earliest Triassic (Griesbachian) age. <i>G.R. Shi [guang@uow.edu.au] and Sangmin Lee [sangminlee76@gmail.com], School of Earth, Atmospheric and Life Sciences, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia; Ian Metcalfe [imetcal2@une.edu.au], Earth Sciences, Earth Studies Building C02, School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia; Daoliang Chu [chudl@cug.edu.cn], State Key Laboratory of Biogeology and Environmental Geology, School of Earth Sciences, China University of Geosciences, Wuhan 430074, PR China; Huiting Wu [ht_wu415@163.com], College of Geoscience and Surveying Engineering, China University of Mining & Technology, Beijing, PR China; Tinglu Yang [yang@geology.hk], Faculty of Geosciences, East China University of Technology, Nanchang 330013, PR China; Yuri D. Zakharov [yurizakh@mail.ru], Far East Geological Institute, Far East Branch, Russian Academy of Sciences, Vladivostok, 690022 Russia.</i>
DOI: 10.6084/m9.figshare.19953686.v1
title: Marine invertebrate fossils from the Permian–Triassic boundary beds of two core sections in the northern Perth Basin, Western Australia

description: Marine macroinvertebrate fossils from two petroleum exploration cores, Apium-1 and Redback-2, are described, and found to contain two separate assemblages. The assemblage from the Apium-1 core was recovered from an <i>ca</i> 5-m-thick interval (2756.35–2751.28 m) in the basal Hovea Member (‘inertinitic interval’) of the Kockatea Shale and includes the following forms: ?<i>Spinomarginifera</i> sp., <i>Cimmeriella</i> sp., ?<i>Etherilosia</i> sp., <i>Elivina</i> sp., <i>Cleiothyridina</i> sp., and Paeckelmanelloidea gen. et. sp. indet. (all brachiopods). The age of this assemblage is interpreted as Changhsingian, as constrained by its association with the palynofloral <i>Dulhuntyispora parvithola</i> Zone. The assemblage from the Redback-2 core was recovered from the ‘sapropelic interval’ of the Hovea Member of the Kockatea Shale between 3806 m and 3786 m and comprises the following forms: Lingulidae gen. et sp. indet. (brachiopod), <i>Claraia perthensis</i> Dickins & McTavish, <i>Crittendenia</i> cf. <i>australasiatica</i> (Krumbeck), ?<i>Paralledon</i> sp. (bivalves), ?<i>Otoceras</i> sp. (ammonoid), <i>Microconchus utahensis</i> Zatoń, Taylor & Vinn (microconchid) and <i>Magniestheria mangaliensis</i> (Jones) (spinicaudatan). Among these, the first local appearances of the lingulid species, ?<i>Otoceras</i> sp. and <i>M. mangaliensis</i> are associated with the palynofloral <i>Protohaploxypinus microcorpus</i> Zone and are interpreted as latest Changhsingian in age. Other occurrences of the Redback-2 fossil assemblage overlap with the palynofloral <i>Kraeuselisporites saeptatus</i> Zone and are considered to be of earliest Triassic (Griesbachian) age. <i>G.R. Shi [guang@uow.edu.au] and Sangmin Lee [sangminlee76@gmail.com], School of Earth, Atmospheric and Life Sciences, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia; Ian Metcalfe [imetcal2@une.edu.au], Earth Sciences, Earth Studies Building C02, School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia; Daoliang Chu [chudl@cug.edu.cn], State Key Laboratory of Biogeology and Environmental Geology, School of Earth Sciences, China University of Geosciences, Wuhan 430074, PR China; Huiting Wu [ht_wu415@163.com], College of Geoscience and Surveying Engineering, China University of Mining & Technology, Beijing, PR China; Tinglu Yang [yang@geology.hk], Faculty of Geosciences, East China University of Technology, Nanchang 330013, PR China; Yuri D. Zakharov [yurizakh@mail.ru], Far East Geological Institute, Far East Branch, Russian Academy of Sciences, Vladivostok, 690022 Russia.</i>
DOI: 10.6084/m9.figshare.4225493
title: Semismooth Newton Coordinate Descent Algorithm for Elastic-Net Penalized Huber Loss Regression and Quantile Regression

description: We propose an algorithm, semismooth Newton coordinate descent (SNCD), for the elastic-net penalized Huber loss regression and quantile regression in high dimensional settings. Unlike existing coordinate descent type algorithms, the SNCD updates a regression coefficient and its corresponding subgradient simultaneously in each iteration. It combines the strengths of the coordinate descent and the semismooth Newton algorithm, and effectively solves the computational challenges posed by dimensionality and nonsmoothness. We establish the convergence properties of the algorithm. In addition, we present an adaptive version of the “strong rule” for screening predictors to gain extra efficiency. Through numerical experiments, we demonstrate that the proposed algorithm is very efficient and scalable to ultrahigh dimensions. We illustrate the application via a real data example. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.16807783
title: Additional file 3 of Lethal variants in humans: lessons learned from a large molecular autopsy cohort

description: Additional file 3: Supplementary Tables S2-S5. Table S2: Level of very long chain fatty acids in patient 18DG0989. Values with asterisk are elevated. Table S3: Breakdown of genes with no OMIM phenotype. No OMIM phenotype*: Case phenotype is not listed in OMIM. Table S4: Breakdown of the diagnostic yield by phenotypic outcome and consanguinity status. Genes in bold are mutated in more than one family. Table S5: Founder variants in this study and their frequency in Saudi and other populations. CGM: local ES database.
DOI: 10.6084/m9.figshare.16807783.v1
title: Additional file 3 of Lethal variants in humans: lessons learned from a large molecular autopsy cohort

description: Additional file 3: Supplementary Tables S2-S5. Table S2: Level of very long chain fatty acids in patient 18DG0989. Values with asterisk are elevated. Table S3: Breakdown of genes with no OMIM phenotype. No OMIM phenotype*: Case phenotype is not listed in OMIM. Table S4: Breakdown of the diagnostic yield by phenotypic outcome and consanguinity status. Genes in bold are mutated in more than one family. Table S5: Founder variants in this study and their frequency in Saudi and other populations. CGM: local ES database.
DOI: 10.5258/soton/d0677
title: Dataset supporting the publication "AMI for Nonlinearity Mitigation in O-Band Transmission"

description: This dataset is supporting the publication:
N. Taengnoi, K. R. H. Bottrill, C. Lacava, D. J. Richardson and P. Petropoulos, "AMI for Nonlinearity Mitigation in O-Band Transmission," 2019 Optical Fiber Communications Conference and Exhibition (OFC), San Diego, CA, USA, 2019, pp. 1-3.
https://doi.org/10.1364/OFC.2019.Th2A.33

The data includes excel files that utilise the alternate mark inversion (AMI) scheme to mitigate the nonlinearity in O-band transmission. The results after transmission over 60km of SMF show that AMI outperforms the duobinary and on-off keying formats.
The data for each figure is contained within a directory of the same name. Data files are named after the Figure they correspond to and contain the data necessary to recreate the plots. Data for Fig-1 is not included, as it is a schematic. Data for Fig-3-c is also not included in the dataset as the data is obtained from screenshots.

Data is accessible via CC BY license
DOI: 10.6084/m9.figshare.6323111
title: Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: <i>in vitro</i> and <i>in vivo</i> evaluation

description: <b>Objective:</b> Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs <i>in vivo</i>. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system. <b>Methods:</b> In this study, natural chlosterol (CC) and folic acid (FA) were used to fabricate polysialic acid (PSA) micelles for the targeted delivery of Dexamethasone (Dex). The biodistribution and therapeutic efficacy of the resulting micelles were evaluated <i>in vitro</i> and <i>in vivo</i>. <b>Results:</b> PSA-CC and FA-PSA-CC micelles showed a size below 100 nm and a moderate negative charge. PSA-CC and FA-PSA-CC micelles could also enhance the intracellular uptake of Dex and the suppression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) <i>in vitro</i> and <i>in vivo</i>. Arthritis mice showed reduced paw thickness and clinical arthritis index using PSA-CC and FA-PSA-CC micelle treatment. Micellized Dex demonstrated a 4 ∼ 5 fold longer elimination half-life and a 2 ∼ 3 folds higher bioavailability than commercial Dex injection. FA modification significantly improved the anti-inflammatory efficacy of PSA-CC micelles. <b>Conclusion:</b> FA-PSA-CC micelles demonstrated significant advantages in terms of the suppression of inflammation and the treatment of inflammatory arthritis. These reliable and stable micelles possess a high potential to be transferred for clinical use.
DOI: 10.6084/m9.figshare.6323111.v1
title: Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: <i>in vitro</i> and <i>in vivo</i> evaluation

description: <b>Objective:</b> Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs <i>in vivo</i>. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system. <b>Methods:</b> In this study, natural chlosterol (CC) and folic acid (FA) were used to fabricate polysialic acid (PSA) micelles for the targeted delivery of Dexamethasone (Dex). The biodistribution and therapeutic efficacy of the resulting micelles were evaluated <i>in vitro</i> and <i>in vivo</i>. <b>Results:</b> PSA-CC and FA-PSA-CC micelles showed a size below 100 nm and a moderate negative charge. PSA-CC and FA-PSA-CC micelles could also enhance the intracellular uptake of Dex and the suppression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) <i>in vitro</i> and <i>in vivo</i>. Arthritis mice showed reduced paw thickness and clinical arthritis index using PSA-CC and FA-PSA-CC micelle treatment. Micellized Dex demonstrated a 4 ∼ 5 fold longer elimination half-life and a 2 ∼ 3 folds higher bioavailability than commercial Dex injection. FA modification significantly improved the anti-inflammatory efficacy of PSA-CC micelles. <b>Conclusion:</b> FA-PSA-CC micelles demonstrated significant advantages in terms of the suppression of inflammation and the treatment of inflammatory arthritis. These reliable and stable micelles possess a high potential to be transferred for clinical use.
DOI: 10.6084/m9.figshare.19430360
title: Genome annotation data for thebig-head schizothorcin (Aspiorhynchus laticeps)

description: The genome annotation files of <i>Aspiorhynchus laticeps</i> such as gff3, cds and protein files were shown in our dataset.