cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11474706.v1
title: The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells

description: Emerging evidence has suggested that long noncoding RNAs (lncRNAs) play an essential role in the tumorigenesis of multiple types of cancer including gastric cancer (GC). However, the potential biological roles and regulatory mechanisms of lncRNA in response to cisplatin, which may be involved in cisplatin resistance, have not been fully elucidated. In this study, we identified a novel lncRNA, cisplatin resistance-associated lncRNA (CRAL), that was downregulated in cisplatin-resistant GC cells, impaired cisplatin-induced DNA damage and cell apoptosis and thus contributed to cisplatin resistance in GC cells. Furthermore, the results indicated that CRAL mainly resided in the cytoplasm and could sponge endogenous miR-505 to upregulate cylindromatosis (CYLD) expression, which further suppressed AKT activation and led to an increase in the sensitivity of gastric cancer cells to cisplatin <i>in vitro</i> and in preclinical models. Moreover, a specific small molecule inhibitor of AKT activation, MK2206, effectively reversed the cisplatin resistance in GC caused by CRAL deficiency. In conclusion, we provide the first evidence that a novel lncRNA, CRAL, could function as a competing endogenous RNA (ceRNA) to reverse GC cisplatin resistance via the miR-505/CYLD/AKT axis, which suggests that CRAL could be considered a potential predictive biomarker and therapeutic target for cisplatin resistance in gastric cancer.
DOI: 10.6084/m9.figshare.19863104.v1
title: Additional file 21 of Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

description: Additional file 21 Supplementary Table S20. The p-value distribution of randomly subsampled LUSC00 Cox multivariate modules using clinical covariates and both CoCNV and CoDM scores.
DOI: 10.6084/m9.figshare.24581943
title: Data for "Single-Molecule Studies of Cognate and Near-Cognate Elongation in an <i>in vitro</i> Eukaryotic Translation System".

description: The data deposited here are part of a study to determine the kinetic features of the elongation cycle of protein synthesis using an <i>in vitro</i> Eukaryotic translation system and single-molecule fluorescence resonance energy transfer (smFRET).
DOI: 10.34740/kaggle/dsv/7724105
title: BBC News
DOI: 10.6084/m9.figshare.19863113
title: Additional file 3 of Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

description: Additional file 3. Supplementary Table S2. PMI/PCC networks recall TFCoTR relationships.
DOI: 10.6084/m9.figshare.19863113.v1
title: Additional file 3 of Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

description: Additional file 3. Supplementary Table S2. PMI/PCC networks recall TFCoTR relationships.
DOI: 10.6084/m9.figshare.19863122
title: Additional file 6 of Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

description: Additional file 6. Supplementary Table S5. PMI/PCC networks recall PPI relationships.
DOI: 10.6084/m9.figshare.19863128.v1
title: Additional file 8 of Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

description: Additional file 8. Supplementary Table S7. Zscores of PCC networks recall CoCNV relationships.
DOI: 10.6084/m9.figshare.19863131
title: Additional file 9 of Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

description: Additional file 9. Supplementary Table S8. PMI/PCC networks recall CoCNV GG relationships.
DOI: 10.6084/m9.figshare.13534922
title: Additional file 2 of Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy

description: Additional file 2. Table S, Sheets 1. MACS control unique genes. Table S, Sheets 2. MACS DCM unique genes. Table S, Sheets 3. SICER control unique genes. Table S, Sheets 4. SICER DCM unique genes. Table S, Sheets 5. MACS control GO genes. Table S, Sheets 6. MACS control pathway genes. Table S, Sheets 7. SICER control GO genes. Table S, Sheets 8. SICER control pathway genes. Table S, Sheets 9. SICER DCM GO genes. Table S, Sheets 10. SICER DCM pathway genes. Table S, Sheets 11. MACS control overlap genes. Table S, Sheets 12. MACS DCM overlap genes. Table S, Sheets 13. SICER control overlap genes. Table S, Sheets 14. SICER DCM overlap genes. Table S, Sheets 15. 60 SICER candidate genes.
DOI: 10.6084/m9.figshare.19863009
title: Additional file 2 of QTL mapping and identification of genes associated with the resistance to Acanthoscelides obtectus in cultivated common bean using a high-density genetic linkage map

description: Additional file 2.
DOI: 10.6084/m9.figshare.13534922.v1
title: Additional file 2 of Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy

description: Additional file 2. Table S, Sheets 1. MACS control unique genes. Table S, Sheets 2. MACS DCM unique genes. Table S, Sheets 3. SICER control unique genes. Table S, Sheets 4. SICER DCM unique genes. Table S, Sheets 5. MACS control GO genes. Table S, Sheets 6. MACS control pathway genes. Table S, Sheets 7. SICER control GO genes. Table S, Sheets 8. SICER control pathway genes. Table S, Sheets 9. SICER DCM GO genes. Table S, Sheets 10. SICER DCM pathway genes. Table S, Sheets 11. MACS control overlap genes. Table S, Sheets 12. MACS DCM overlap genes. Table S, Sheets 13. SICER control overlap genes. Table S, Sheets 14. SICER DCM overlap genes. Table S, Sheets 15. 60 SICER candidate genes.
DOI: 10.6084/m9.figshare.19863009.v1
title: Additional file 2 of QTL mapping and identification of genes associated with the resistance to Acanthoscelides obtectus in cultivated common bean using a high-density genetic linkage map

description: Additional file 2.
DOI: 10.15468/nh86uh
title: Données Sologne Nature Environnement-Sologne Nature Environnement - Données Cistude d'Europe 1954-2021

description: Données d'observation de Cistude d'Europe Emys orbicularis produites par l'association Sologne Nature Environnement entre 1954 et 2021.
DOI: 10.15468/gfgwg6
title: [SUIVI] 2022 Inventaire annuel du parc Jonquieres 2 - Faune suivi 2022 Jonquiere

description: Données suivi faune 2022. Suivi environnemental 2022 du parc Jonquieres 2 situé sur la commune de Jonquieres (84 150). La surface de l'emprise du projet est d'environ 2,3 ha.
DOI: 10.15468/zc8fvh
title: Ecoquartier de l'Eau Vive - Phase 2 - Inventaire naturaliste zone de compensation ex-situ

description: Les investigations naturalistes ont porté sur les habitats et la flore, l’avifaune et les chiroptères - pour la zone de compensation ex situ - Ecoquartier de l'Eau Vive - ZAC Pyramide à Lieusaint
DOI: 10.6084/m9.figshare.21436327
title: Reconstructing the East Palaeotethyan assemblage boundary at West Indonesia: constraints from Triassic granitoids in Bangka and Belitung islands

description: Table S1, summary of sampling locations, zircon U–Pb and in situ Hf–O analyses of the granitoids in Bangka and Belitung islands, Indonesia; Table S2, whole-rock major oxides, trace elemental and Sr–Nd–Pb isotopic data for the Triassic granitoids in Bangka and Belitung islands, Indonesia; Table S3, LA-ICP-MS zircon U–Pb data for the Triassic granitoids in Bangka and Belitung islands, Indonesia; and Table S4, zircon in situ Hf-O isotopic data for the Triassic granitoids in Bangka and Belitung islands, Indonesia
DOI: 10.15468/gm5zu4
title: Parc éolien de Sacquenay-Eolien Sacquenay Source Mistral suivi Busards 2019 à 2022

description: Eolien Sacquenay Source Mistral suivi Busards 2019 à 2022
DOI: 10.15468/st3x6k
title: Centrale photovoltaïque du Pouzin II-PV Pouzin 2 suivi chiro 2022

description: PV Pouzin 2 suivi chiro 2022
DOI: 10.6084/m9.figshare.21436327.v1
title: Reconstructing the East Palaeotethyan assemblage boundary at West Indonesia: constraints from Triassic granitoids in Bangka and Belitung islands

description: Table S1, summary of sampling locations, zircon U–Pb and in situ Hf–O analyses of the granitoids in Bangka and Belitung islands, Indonesia; Table S2, whole-rock major oxides, trace elemental and Sr–Nd–Pb isotopic data for the Triassic granitoids in Bangka and Belitung islands, Indonesia; Table S3, LA-ICP-MS zircon U–Pb data for the Triassic granitoids in Bangka and Belitung islands, Indonesia; and Table S4, zircon in situ Hf-O isotopic data for the Triassic granitoids in Bangka and Belitung islands, Indonesia
DOI: 10.15468/knaqku
title: [SUIVI] 2019-2022 - Exploitation de la sablière de la société Sablière OESCH à Lingolsheim (67) - Faune inventoriée par ENCEM sur la sablière de Lingolsheim en 2022

description: Oiseaux, amphibiens et reptiles inventoriés par ENCEM sur la sablière de Lingolsheim lors d'une campagne d'inventaire les 15 et 16/06/2022
DOI: 10.15468/yc5emq
title: Parc éolien de Pays d'Anglure-Données ICPE suivi Busard 2022 - parc éolien de Pays d'anglure (51)

description: Données ICPE suivi Busard 2022 - parc éolien de Pays d'anglure (51)
DOI: 10.6084/m9.figshare.11998809.v1
title: Additional file 5 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 5 Top 3 enriched pathways, with associated p-values from the hypergeometric test. Data provided as an Excel spread sheet.
DOI: 10.15468/fv6vvr
title: Projet de serres-tunnels au lieu-dit « Les Malançons» à Sarrians (84)-Inventaires des Odonates, Lépidoptères

description: Le jeu de données regroupe les données d’observation d’espèces d’Odonates et de lépidoptères Rhopalocères sur la commune de Sarrians
DOI: 10.6084/m9.figshare.11998797.v1
title: Additional file 3 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 3 Coexpression Network. Data provided as a txt file.
DOI: 10.6084/m9.figshare.11998809
title: Additional file 5 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 5 Top 3 enriched pathways, with associated p-values from the hypergeometric test. Data provided as an Excel spread sheet.
DOI: 10.15468/rgkek7
title: 2022_Alain SADORGE_5

description: 2022_SADORGE_3:Alain SADORGE
DOI: 10.6084/m9.figshare.11998788.v1
title: Additional file 2 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 2 Results of Pathway Analysis. Data provided as an Excel spread sheet.
DOI: 10.15468/n63r5a
title: Findings of birds (Aves) in the National Natural Park Tuzlivsky Lagoons and its surrounding area (Ukraine) during the nesting period of 2022

description: The database includes 58 records of bird encounters within the National Natural Park Tuzlivsky Lagoons and its surroundings - the eastern part of the lake Sasyk (in the vicinity of the village Trapivka, Bilhorod-Dnistrovsky district). The records were carried out as part of the traditional monitoring of nesting birds. Attention was primarily paid to waterfowl and near-water bird species. Species that could potentially nest on the site, but their nesting is unproven, were also recorded. Birds that did not nest, but that formed clusters, were also registered. Due to the fact that the connection of the estuaries with the sea was unstable, the water level in the Tuzliv estuaries was low, large areas dried up and became inaccessible for nesting. A similar trend has been observed in the region for several years.
DOI: 10.15468/h7523f
title: ZAC Sevran Terre d'Avenir - Phase 1-Biotope_OISEAU_PE

description: Listes des oiseaux contactés par points d'écoute par BIOTOPE dans le cadre des prospections de terrain réalisées au niveau de la plaine de Monteceleux à Sevran (93) en 2022.
DOI: 10.15468/ctd7d7
title: [SUIVI] 2022 - Exploitation de la carrière du Lyaud de la société des Carrières Chablaisiennes-Faune inventoriée par ENCEM dans la carrière du Lyaud en 2022

description: Faune (insectes, oiseaux, reptiles, amphibiens) inventoriée entre les mois de mai et juin 2022
DOI: 10.15468/g3majn
title: Invasive and neolimnetic fish species in Dnipro, Danube and some others basins (Ukraine, 2022-2023)

description: The dataset consists of records of invasive and neolimnetic fish species, made in 2022-2023.
DOI: 10.15468/u8zy6s
title: Suivi enviro parc éolien épine amanty 2022-Epine amanty suivi IPA avifaune 2022

description: Epine amanty suivi IPA avifaune 2022
DOI: 10.15468/8vkypu
title: Records of flies from Syrphidae family in Western Ukraine

description: The dataset includes 2000 records of 143 species of hover flies, collected in 7 regions of Western Ukraine during 2005-2022. According to the IUCN, the presented species have different statuses - Data Deficient (DD), Endangered (EN), Near Threatened (NT), Least Concern (LC). Temnostoma meridionale is included in the Red Book of Ukraine (category: Vulnerable). The overwhelming majority of the finds belong to the Volhynian-Podolian Upland. The collections include data from the territories of protected areas - Malovanka landscape park, Podilski Tovtry, Male Polissia, Skolivski Beskydy national parks, Medobory, Roztochia and Rivnenskyi nature reserves.
DOI: 10.15468/d2sak7
title: Projet d'aménagement de la Frayère aval - Cannes (06)-Poissons - Inventaire non standardisé - 1

description: Liste des poissons contactés dans le cadre des prospections de terrain réalisées au niveau de l'aire d'étude du projet d'aménagement de la Frayère aval à Cannes (06).
DOI: 10.15468/dtmcw3
title: CardObs : Observations naturalistes issues de l'outil CardObs-Inventaire des Anthophila et sphecidés de la RNR des Gorges de DALUIS

description: Capture des espèces d'hyménoptères (Anthophila et sphecidae) par tente malaise et à vue au filet
DOI: 10.15468/z6sv34
title: [SUIVI] 2022 - Inventaire annuel du parc solaire de Le Mouruen (Signes)-JDD Faune - Suivi 2022 - parc solaire de Le Mouruen (Signes)

description: Inventaire annuel (2022) du parc solaire de Le Mouruen situé sur la commune de Signes (83 870). La surface clôturé est de 14 ha environ.
DOI: 10.15468/jy8rsn
title: Biodiversity through students' eyes - Marcoussis, 2022 - ENGIE Renewables

description: The data were collected as part of ENGIE Renewables’ project : Biodiversity through students' eyes. This project is led in partnership with the French Committee of the International Union for Conservation of Nature (IUCN), the National Museum of Natural History (NMHN) and the University of Paris-Saclay. The aim of the project is to enable students to observe biodiversity in an operational renewable energy production site. Observations are carried out by students in first year of master degree in ecology in the Marcoussis‘ solar photovoltaic power plant (Essonne, France). They use participatory science protocols developed by Vigie-Nature (NMHN program). Bird observations were made using the STOC protocol. The same 11 listening points were recorded during three successive outings between March and June 2022 on the Marcoussis power plant. During each outing, the group of students carried out the listening points in the reverse order to the previous outing, to eliminate any bias linked to the time of day. Flora observations were made using the Vigie-Flore protocol. One flora outing was carried out in june 2022. The line 2 to line 12 inclusive: corresponds to an area where photovoltaic panels are located. The line 13 to line 64 inclusive: corresponds to a Refuge zone forbidden to human prospecting and without photovoltaic panels. The line 65 to 84 inclusive: corresponds to a buffer zone (between the panel zone and the refuge zone). Pollinator observations were made using the SPIPOLL protocol. There are 1 date because 1 pollinator outing was carried out in June 2022. Odonates observations were made using the STELI protocol. Two odonates outing was carried out in June 2022. The line 2 to line 8 inclusive and 13 to 19 inclusive: corresponds to a Refuge zone forbidden to human prospecting and without photovoltaic panels. The line 9 to 12 inclusive and 21 and 21 inclusive: corresponds to an area where photovoltaic panels are located.
DOI: 10.15468/tfywyp
title: Confortement de la digue domaniale de Sermoise (non soumis à étude d’impact)-Étude environnementale de la digue de Sermoise

description: Étude environnementale permettant de dresser l’état initial de l’environnement naturel
DOI: 10.15468/qy3aax
title: Projet d'aménagement de la Frayère aval - Cannes (06)-Reptiles - Inventaire non standardisé - 1

description: Liste des reptiles observés dans le cadre des prospections de terrain réalisées au niveau de l'aire d'étude du projet d'aménagement de la Frayère aval à Cannes (06).
DOI: 10.15468/xkn2dm
title: Suivi écologique de la carrière de Wasselonne (société Chaux de Wasselonne) - [SUIVI] 2022 - écologique faune carrière de Wasselonne

description: Données faunistiques récoltées dans le cadre du suivi écologique sur la carrière de Wasselonne tel que demandé par l'arrêté préfectoral du 30/11/2016
DOI: 10.15468/3h7ngs
title: Inventaire des coléoptères saproxyliques de France métropolitaine-Données Tenebrionoidea transmises pour l'Atlas préliminaire par la société Naturalia

description: Données Tenebrionoidea transmises pour l'Atlas préliminaire par la société Naturalia, par Sylvain Fadda, sous convention avec l'ACOREP France
DOI: 10.15468/bhmh37
title: Centrale photovoltaïque de Bollène II-PV Bollène 2 Suivi Flore 2018 à 2022

description: PV Bollène 2 Suivi Flore 2018 à 2022
DOI: 10.15468/mpz9j2
title: Parc éolien de La Saronde-Suivi busards 2022 La Saronde

description: Suivi des Busard et autres observations en 2022 sur le parc éolien de La Saronde
DOI: 10.15468/sys35k
title: Données de la Fédération des chasseurs du Cher-FDC du Cher - Suivi des amphibiens ENS Morogues 2022

description: Données de suivi des populations d'amphibiens sur le site du territoire des Places à Morogues, réalisé dans le cadre du Plan de gestion 2020-2029 de l’Espace Naturel Sensible, avec le soutien financier du Conseil départemental du Cher et de l’Office Français de la Biodiversité. Utilisation du protocole Amphicapt.
DOI: 10.15468/v5dtqf
title: Données du Parc naturel régional de Corse - Suivi des populations de mouflons réintroduites sur le massif de Cagna

description: Observations lors de protocole de suivi CMR et par pose de piège photo
DOI: 10.15468/ns2kgp
title: parc eolien de AÉRODIS LES CHAUMES-Données naturalistes - suivi mortalité 2022 - Chiroptères

description: Données naturalistes - suivi mortalité 2022 -- Chiroptères
DOI: 10.15468/epaw6b
title: Projet d'aménagement de la Frayère aval - Cannes (06)-Oiseaux - Inventaire non standardisé - 1

description: Liste des oiseaux contactés dans le cadre des prospections de terrain réalisées au niveau de l'aire d'étude du projet d'aménagement de la Frayère aval à Cannes (06).
DOI: 10.15468/p8yd55
title: Pose de canalisation de transport de gaz naturel à Valensole-Suivi Faune 2021-2022

description: Pose de canalisation de transport de gaz naturel à Valensole Dépot de données recueillies lors des suivis post chantier
DOI: 10.15470/3lztzf
title: AlgaCAT, Banco de datos de las algas de Catalu?a

description: AlgaCatCat es un banco de datos que recoge las observaciones sobre las algas (marinas y continentales) que aparecen en la bibliograf?a especializada en el marco territorial de Catalu?a. Tambi?n se recoge la informaci?n taxon?mica, ecol?gica, corol?gica, etc.
DOI: 10.15468/m3qvsk
title: Projet d'aménagement de la Frayère aval - Cannes (06)-Insectes - Inventaire non standardisé - 1

description: Liste des insectes observés dans le cadre des prospections de terrain réalisées au niveau de l'aire d'étude du projet d'aménagement de la Frayère aval à Cannes (06).
DOI: 10.15468/qnw6dx
title: Projet d'aménagement de la Frayère aval - Cannes (06)-Amphibiens - Inventaire non standardisé - 1

description: Liste des amphibiens observés dans le cadre des prospections de terrain réalisées au niveau de l'aire d'étude du projet d'aménagement de la Frayère aval à Cannes (06).
DOI: 10.15468/99f2rv
title: Records of birds from Mykolaiv administrative region of Ukraine according to some literature resources

description: The dataset represents the digitalized records of birds of various conservation status, found on the territory of Mykolaiv region of Ukraine and which were reported in the scientific article: "Редінов К.О., Петрович З.О., Панченко П.С., Форманюк О.О., Настаченко О.С. Інвентаризаційний список орнітофауни Кінбурнського півострова та прилеглих акваторій у межах Миколаївської області - Berkut. 31 (1-2). 2022.", - and other materials cited in this scientific paper, which contained information of ornithofauna of the target region.
DOI: 10.15468/nmxjsb
title: Parc éolien d’Amoures-Bouissac-Données chiro WGS84

description: Données chiro / Dix-neuf éoliennes ayant une génératrice électrique d'une puissance nominale d’environ 2,3 MW constitueront le parc éolien d’Amoures-Bouissac sur les communes de CEILHES-ET-ROCOZELS et FONDAMENTE. La hauteur maximale atteinte par les pales sera de 99,5 m par rapport au sol. L’ensemble de ces éoliennes sera raccordé sur deux postes de livraison localisés l’un au centre du parc et l’autre à l’extrémité Est.
DOI: 10.15468/jbtmvu
title: Parc éolien de la Motte-de-Galaure-Eolien Motte de Galaure suivi enviro 2022

description: Eolien Motte de Galaure suivi enviro 2022
DOI: 10.15468/vbycwv
title: [SUIVI] Exploitation de la gravière de Rhinau (67)-Faune inventoriée par ENCEM sur la gravière de Rhinau en 2022

description: Faune (tous taxons) inventoriés par ENCEM sur le périmètre autorisé de la gravière de Rhinau entre le 20/04 et le 20/07/2022, en trois campagnes.
DOI: 10.15468/r9hhwa
title: Expertise IQE du Golf de Servanes en 2022-Données espèces - Expertise IQE Golf de Servanes 2022

description: Dans le cadre du partenariat entre la ffgolf et le MNHN, le Programme Golf pour la biodiversité propose aux golfs de s'inscrire dans une démarche volontaire de connaissance et de préservation de la biodiversité qui se trouve sur leur foncier. Ce jeu de données correspond aux données espèces de l’expertise IQE réalisée sur le Golf de Servanes réalisée en 2022.
DOI: 10.6084/m9.figshare.13047477
title: Additional file 1 of C3: connect separate connected components to form a succinct disease module

description: Additional file 1: Supplementary data and results.
DOI: 10.6084/m9.figshare.13047477.v1
title: Additional file 1 of C3: connect separate connected components to form a succinct disease module

description: Additional file 1: Supplementary data and results.
DOI: 10.6084/m9.figshare.11998788
title: Additional file 2 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 2 Results of Pathway Analysis. Data provided as an Excel spread sheet.
DOI: 10.6084/m9.figshare.11998806.v1
title: Additional file 4 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 4 Curated Network. Data provided as an Excel spread sheet.
DOI: 10.6084/m9.figshare.11998797
title: Additional file 3 of Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

description: Additional file 3 Coexpression Network. Data provided as a txt file.
DOI: 10.6084/m9.figshare.13572025
title: Additional file 1 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

description: Additional file 1: Table S1. Cohort statistics.