cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25231829
title: Supplementary Material for: Clinical Landscape of Central Serous Chorioretinopathy in Germany - Retina.net CSC Registry Report No 1

description: Background. The German Registry of Central serous chorioretinopathy (CSC) collects data on CSC patients in a nationwide multicenter approach to analyze epidemiology, risk factors, clinical presentations as well as diagnosis and treatment patterns.
Material and Methods. In this multicenter cohort study, patients with CSC were enrolled in nine tertiary referral centers in Germany between January 2022 and June 2023. After consenting to the study, demographic data, risk factors, reported symptoms, best corrected visual acuity (BCVA), funduscopic findings, disease severity, and diagnostic and treatment decisions were recorded and analyzed.
Results. A total of 539 eyes of 411 CSC patients were enrolled in this study including 308 male (75%) and 103 female (25%). Patients were predominantly of Caucasian origin and had a mean age of 55.5 years (IQR 41.0 - 70.0). 28% of eyes were classified as acute (&lt;4 months duration) CSC, 28% as chronic (&gt;4 months duration) CSC, 21% as inactive CSC, 11% as chronic atrophic CSC, and 12% as CSC with secondary CNV. 128 patients (31%) demonstrated bilateral CSC. The most common risk factors reported were psychological stress (52%), smoking (38%), arterial hypertension (38%), and a history of or current use of steroids (30%). Most frequently encountered symptoms included decreased visual acuity (76%), metamorphopsia (49%), relative scotoma (47%), blurred vision (19%), and dyschromatopsia (9%). Mean logMAR BCVA on initial examination was 0.2 (≈20/30, IQR 0.2 - 0.4), but showed significant variation with a tendency of lower BCVA in chronic cases. At the baseline visit, 74% of the overall cohort received no treatment, while 19% underwent local treatment and only 2% systemic treatment. Of the local therapies, anti-VEGF injections were the most frequently performed procedure (33%, mainly for secondary CNV), followed by micropulse laser (28%), focal non-pulsed laser (23%), photodynamic therapy (14%), and nonsteroidal anti-inflammatory eye drops (2%). Among intravitreal anti-VEGF agents, aflibercept was used most frequently, followed by bevacizumab and ranibizumab.
Discussion. This registry represents one of the largest cohorts of European patients with CSC to date. Patient age and the proportion of women was higher than expected and bilateral active disease was lower than anticipated, highlighting that neither age nor gender should be overemphasized when diagnosing CSC. Therapeutic interventions are heterogeneous and include photodynamic therapy, micropulse laser and anti-VEGF injections in case of secondary CNV.
DOI: 10.6084/m9.figshare.7641257.v1
title: Additional file 4: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Gojal Hunza. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.11835570.v1
title: Prenatal risk factors for urgent atrial septostomy at birth in fetuses with transposition of the great arteries: a systematic review and meta-analysis

description: <b>Purpose of the article.</b> To explore the role of fetal echocardiography in predicting the risk of urgent balloon atrial septostomy (BAS) at birth in fetuses diagnosed with transposition of the great arteries (TGA). Medline, Embase, and Cochrane databases were searched. The primary aim was to explore the differences in prenatal echocardiographic parameters among fetuses diagnosed with TGA that required urgent BAS within 24 h of birth due to life-threatening cyanosis compared to those who did not require such procedure. Random-effect meta-analyses were used to compute the data. Six studies (292 fetuses) were included. Restrictive appearance of the FO was present in 64.5% (95% CI = 39.8–85.7) of fetuses with TGA requiring BAS at birth compared to 7.9% (95% CI = 2.1–16.8) not requiring such procedure (OR = 71.1; 95% CI = 8.3–608.5, <i>p</i> &lt; .0001). Hypermobile appearance of the atrial septum was present in 39.1% (95% CI = 26.4–56.5) of fetuses requiring BAS at birth compared to 9.8% (95% CI = 1.4–24.3) of those which did (OR 3.6; 95% CI = 1.4–9.0, <i>p</i> = .05). There was no difference in the prevalence of redundant (<i>p</i> = .374) or fixed (<i>p</i> = .051) atrial septum, bidirectional flow in the DA (<i>p</i> = .26) or an abnormal size of the DA (<i>p</i> = .06) in fetuses requiring urgent BAS at birth compared to those which did not. Mean (±SD) size of the right atrium was smaller in the fetuses with TGA undergoing urgent BAS at birth (23.4 ± 6.7) compared to those which did not (29.2 ± 6.2, <i>p</i> = .01). The mean (±SD) ratio between the FO and the aortic valve diameters (1.01 ± 0.41 versus 1.41 ± 0.43, <i>p</i> = .009) and the mean (±SD) ratio between the FO diameter and the septal length (0.36 ± 0.13 versus 0.51 ± 0.14, <i>p</i> = .001) were significantly smaller in fetuses requiring compared to those not undergoing urgent BAS at birth. The diagnostic accuracy of each independent ultrasound marker of the need for urgent BAS showed an overall good specificity but a low sensitivity. Fetal echocardiography prior to birth can stratify the risk of BAS in fetuses with TGA. Further studies are needed to validate these findings and build individualized multiparametric predictive models in order to more accurately identify those fetuses with TGA at a higher risk of urgent BAS after birth.
DOI: 10.6084/m9.figshare.7641263
title: Additional file 5: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Jalalabad. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.7641266
title: Additional file 6: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Kargha. (XLSX 17Â kb)
DOI: 10.6084/m9.figshare.7641275.v1
title: Additional file 7: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Nagar. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.7641263.v1
title: Additional file 5: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Jalalabad. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.7641284
title: Additional file 8: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Skardu. (XLSX 19Â kb)
DOI: 10.6084/m9.figshare.7641284.v1
title: Additional file 8: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Skardu. (XLSX 19Â kb)
DOI: 10.6084/m9.figshare.7641290
title: Additional file 9: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Astore. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.7641275
title: Additional file 7: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: RFC and UV of species reported from Nagar. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.11835477.v1
title: Identification of RNA 3´ ends and termination sites in <i>Haloferax volcanii</i>

description: Archaeal genomes are densely packed; thus, correct transcription termination is an important factor for orchestrated gene expression. A systematic analysis of RNA 3´ termini, to identify transcription termination sites (TTS) using RNAseq data has hitherto only been performed in two archaea, <i>Methanosarcina mazei</i> and <i>Sulfolobus acidocaldarius</i>. In this study, only regions directly downstream of annotated genes were analysed, and thus, only part of the genome had been investigated. Here, we developed a novel algorithm (Internal Enrichment-Peak Calling) that allows an unbiased, genome-wide identification of RNA 3´ termini independent of annotation. In an RNA fraction enriched for primary transcripts by terminator exonuclease (TEX) treatment we identified 1,543 RNA 3´ termini. Approximately half of these were located in intergenic regions, and the remainder were found in coding regions. A strong sequence signature consistent with known termination events at intergenic loci indicates a clear enrichment for native TTS among them. Using these data we determined distinct putative termination motifs for intergenic (a T stretch) and coding regions (AGATC). <i>In vivo</i> reporter gene tests of selected TTS confirmed termination at these sites, which exemplify the different motifs. For several genes, more than one termination site was detected, resulting in transcripts with different lengths of the 3´ untranslated region (3´ UTR).
DOI: 10.6084/m9.figshare.7641194
title: Additional file 10: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: Top 10 species from each location for number of uses, ailment categories, RFC, and UV. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.7641194.v1
title: Additional file 10: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: Top 10 species from each location for number of uses, ailment categories, RFC, and UV. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.7641224
title: Additional file 12: of Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

description: Ailment categories. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.14457000.v1
title: Additional file 6 of IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

description: Additional file 6: Table S5. Hashtag antibodies for the 10X single-cell cell hashing experiment.
DOI: 10.6084/m9.figshare.7641371.v1
title: Additional file 1: of MrSVP, a secreted virulence-associated protein, contributes to thermotolerance and virulence of the entomopathogenic fungus Metarhizium robertsii

description: Figure S1. Disruption and complementation of Mrsvp in M. robertsii. (A) Mrsvp was disrupted by homologous recombination, and complementation of this gene was performed using a plasmid construct containing Mrsvp. (B) Confirmation the disruption mutants by PCR. The template is genomic DNA. Mrsvp, PCR was conducted with Mrsvp F and Mrsvp R; bar, PCR was conducted with primers bar F and bar R; ben, PCR was conducted with primers ben F and ben R. CK, control check; WT, wild type; ΔMrSVP, the knockout mutant; Comp, the complementation mutant. (C) Confirmation of the knockout mutants by PCR. The template is cDNA. Detailed information on primers is shown in Table 1. Figure S2. Growth and production of conidia by strains WT, ΔMrSVP, and ΔMrSVP/MrSVP. (A) The growth rate of WT M. robertsii, of the knockout mutant, and of the complementation mutant. (B) The yield of conidia was measured for the WT, ΔMrSVP, and ΔMrSVP/MrSVP. Figure S3. The effects of chemical stress reagents on growth, and the effect of UV-B irradiation on conidial viability. (A) The colony size of strains WT, ΔMrSVP, and of the complementation mutant in the presence of chemical stress reagents. (B) The relative percentage of germination of M. robertsii conidia that were exposed to UV-B radiation. Based on nonirradiated control estimates, relative germination was calculated. (ZIP 1932 kb)
DOI: 10.6084/m9.figshare.14456994
title: Additional file 4 of IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

description: Additional file 4: Table S3. Number of cells per cluster, per disease and tissue for macrophage integration analysis.
DOI: 10.6084/m9.figshare.14456985
title: Additional file 1 of IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

description: Additional file 1: Table S1. Basic information and demography of multiple single-cell datasets.
DOI: 10.6084/m9.figshare.14456991
title: Additional file 3 of IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

description: Additional file 3: Table S2. Cell type marker genes and statistics.
DOI: 10.13145/bacdive155342.20221219.7.1
title: Ornithinimicrobium muralis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155343.20220920.7
title: Burkholderia multivorans

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155343.20221219.7.1
title: Burkholderia multivorans

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155344.20220920.7
title: Corynebacterium striatum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155344.20221219.7.1
title: Corynebacterium striatum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155345.20220920.7
title: Enterococcus faecium

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155345.20221219.7.1
title: Enterococcus faecium

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155346.20220920.7
title: Brachybacterium paraconglomeratum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155346.20221219.7.1
title: Brachybacterium paraconglomeratum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155347.20220920.7
title: Streptococcus pyogenes

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155347.20221219.7.1
title: Streptococcus pyogenes

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155348.20220920.7
title: Stenotrophomonas maltophilia

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155348.20221219.7.1
title: Stenotrophomonas maltophilia

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155349.20220920.7
title: Stenotrophomonas maltophilia

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155349.20221219.7.1
title: Stenotrophomonas maltophilia

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155350.20220920.7
title: Streptococcus sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155350.20221219.7.1
title: Streptococcus sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155351.20220920.7
title: Microbacterium sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155351.20221219.7.1
title: Microbacterium sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155352.20220920.7
title: Clostridium innocuum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155352.20221219.7.1
title: Clostridium innocuum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155353.20220920.7
title: Lactobacillus rhamnosus

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155353.20221219.7.1
title: Lactobacillus rhamnosus

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155354.20220920.7
title: Moraxella osloensis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155354.20221219.7.1
title: Moraxella osloensis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155355.20220920.7
title: Aggregatibacter segnis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155355.20221219.7.1
title: Aggregatibacter segnis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155356.20220920.7
title: Enterococcus avium

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155356.20221219.7.1
title: Enterococcus avium

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155357.20220920.7
title: Actinotignum schaalii

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155357.20221219.7.1
title: Actinotignum schaalii

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155358.20220920.7
title: Catabacter hongkongensis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155358.20221219.7.1
title: Catabacter hongkongensis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155359.20220920.7
title: Corynebacterium pyruviciproducens

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155359.20221219.7.1
title: Corynebacterium pyruviciproducens

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155360.20220920.7
title: Roseomonas aestuarii

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155360.20221219.7.1
title: Roseomonas aestuarii

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155361.20220920.7
title: Brevundimonas diminuta

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155361.20221219.7.1
title: Brevundimonas diminuta

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155362.20220920.7
title: Bacillus sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155362.20221219.7.1
title: Bacillus sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155363.20220920.7
title: Enterococcus gallinarum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155363.20221219.7.1
title: Enterococcus gallinarum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155364.20220920.7
title: Neisseria animaloris

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155364.20221219.7.1
title: Neisseria animaloris

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155365.20220920.7
title: Murinocardiopsis flavida

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155365.20221219.7.1
title: Murinocardiopsis flavida

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155366.20220920.7
title: Amycolatopsis sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive155366.20221219.7.1
title: Amycolatopsis sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.