cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21582906
title: Supplementary Material for: A Randomized Phase 2 Study of 5-Aminolevulinic Acid Hydrochloride and Sodium Ferrous Citrate for the Prevention of Nephrotoxicity Induced by Cisplatin-Based Chemotherapy of Lung Cancer

description: <b><i>Introduction:</i></b> Cisplatin-based chemotherapy was established in the 1980s, and it has been improved by the development of a short hydration protocol in lung cancer therapy. However, cisplatin-based chemotherapy is still associated with renal toxicity. Because 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC) is known to be a mitochondrial activator and a heme oxygenase-1 (HO-1) inducer, 5-ALA with SFC is speculated to mitigate cisplatin-induced renal inflammation. <b><i>Methods:</i></b> We investigated the effects of oral administration of 5-ALA with SFC for preventing cisplatin-based nephrotoxicity in patients with lung cancer and evaluated its benefits for patients who received cisplatin-based chemotherapy. The primary endpoint was the significance of the difference between the serum creatinine (sCr) levels of the patients administered 5-ALA with SFC and those given placebo after course 1 of chemotherapy. The difference in the estimated glomerular filtration rate (eGFR) between the two groups was also evaluated as the secondary endpoint. <b><i>Results:</i></b> The double-blind, randomized two-arm studies were conducted at 15 medical facilities in Japan; 54 male and 20 female patients with lung cancer who received cisplatin-based chemotherapy between the ages of 42 and 75 years were included in the study. The compliance rate was greater than 94% in the primary assessment and subsequent drug administration periods. All enrolled patients completed the four cycles of cisplatin-based chemotherapy with short hydration. The average level of sCr on day 22 of course 1 was 0.707 mg/dL in the group treated with 5-ALA and SFC and 0.735 mg/dL in the placebo group, respectively, and the sCr in the test group was significantly lower than that in the placebo group (<i>p =</i> 0.038). In addition, the eGFR was significantly higher in the SPP-003 group than in the placebo group up to day 1 of course 3 (84.66 and 75.68 mL/min/1.73 m<sup>2</sup>, respectively, <i>p =</i> 0.02) and kept better even after the last administration of the study drug (82.37 and 73.49 mL/min/1.73 m<sup>2</sup>, respectively, <i>p =</i> 0.013). <b><i>Conclusions:</i></b> The oral administration of 5-ALA with SFC is beneficial to patients undergoing cisplatin-based chemotherapy for lung cancer with short hydration.
DOI: 10.6084/m9.figshare.21657404
title: Supplementary Material for: DISCORDANCE BETWEEN ANTERIOR SEGMENT ANATOMY AND AXIAL LENGTH IN CATARACT SURGERY CANDIDATES IN FRANCE

description: Introduction: To study ocular biometric data and their association with age and sex in a population of cataract surgery candidates. To assess the proportion of inhomogeneous eyes and the ratio anterior segment (AS) to axial length (AL). Multicentric cross-sectional analysis between April 2008 and May 2021 in public and private ophthalmic institutions in Montpellier, France. Individuals ≥ 40 years old who underwent ocular biometry before cataract surgery were included. Methods: Right phakic eyes were included. Ocular biometrics were measured by using the Lenstar LS900 device. We defined AS as anterior chamber depth (ACD) plus lens thickness (LT) and calculated the ratio of AS to AL. We defined inhomogeneous eyes as those with deep AS (≥ 4th quartile) and short AL (≤ 1st quartile) (AS+) or with short AS and high AL (AL+). Results: We included 11,650 individuals (11,650 eyes) (mean [SD] age 71.64 [10.50] years; 54.51% women). Older age was associated with shorter AL (p&lt;0.01), shallower ACD (p &lt; 0.01), thinner central corneal thickness (p&lt; 0.01) and larger LT (p&lt;0.001). Women had shorter AL, shallower ACD, and thinner central corneal thickness than men (p&lt;0.001). In total, 778 (6.68%) eyes were inhomogeneous (3.22% AS+ and 3.46% AL+), for a mean (SD) AS/AL ratio of 0.36 (0.01) and 0.28 (0.01), respectively, as compared with 0.32 (0.02) for homogeneous eyes (p&lt;0.001). Conclusion: The AS/AL ratio could be useful to screen inhomogeneous eyes before cataract surgery and justify the use of new generation formulas in these eyes to avoid the risk of refractive error.
DOI: 10.6084/m9.figshare.21657407
title: Supplementary Material for: The Effect of Prostaglandin Analogues on Central Corneal Thickness of Patients with Glaucoma or Ocular Hypertension: a systematic review

description: Purpose: A meta-analysis of observational studies was conducted to evaluate the effect of prostaglandin analogues (PGAs) on central cornea thickness (CCT) of patients with glaucoma and ocular hypertension (OHT). Methods: A literature search was performed through Pubmed, Embase, Cochrane Library, the System for Information on Grey Literature in Europe (Open Grey), ClinicalTrials.gov, and reference lists of retrieved studies. Observational studies were included in our meta-analysis. The final CCT of patients and 95% confidence interval (CI) from each study were extracted. Study quality was assessed using The Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ). A fixed-effects model was used to calculate the weighted mean difference (WMD) and 95% confidence interval (CI). Subgroup analyses based on several stratified factors were also performed. Results: Five cohort studies, five case-control, three cross-sectional studies involving 2722 subjects were included. The pooled effect of all thirteen studies showed PGAs can reduce CCT of patients with glaucoma or OHT slightly but significantly (WMD, -9.37; 95% CI [-12.18, -6.57], P =0.00; I2 = 45.5%). And significant results were observed in all specific study design ( WMD, -5.17; 95% CI [-9.52, -0.82] for cohort study; WMD, -15.31; 95% CI [-22.66, -7.97] for case–control study; WMD, -8.65; 95% CI [-17.30, -0.01] for cross-sectional study). Also, subgroup analysis of exposure time showed the effect of PGAs was more obvious in the first two years (WMD, -5.81; 95% CI [-9.49, -2.14] for 1 year; WMD, -13.02; 95% CI [-20.03, -6.01] for 2 years). Conclusions: The pooled effects from current literature suggest that PGAs use could reduce CCT of patients with glaucoma or OHT slightly but significantly, and this effect is more pronounced in the first two years. This reminds us that we need to pay attention to the changes in CCT during the first two years of PGA use in case we misestimate intraocular pressure (IOP) and the efficacy of the PGA.
DOI: 10.34740/kaggle/dsv/4642672
title: AutoXGB
DOI: 10.34740/kaggle/dsv/4642666
title: Health Workforce Shortage Areas
DOI: 10.6084/m9.figshare.21670343
title: original data

description: In this study, by using peritoneal macrophage and J774A.1 mononuclear macrophage in vitro and dextran sulfate sodium (DSS)-induced colitis mice model in vivo, we found that disulfiram with Cu2+ could significantly reverse the symptom of dextran sulfate sodium (DSS)-induced ulcerative colitis, such as weight loss, disease activity index score; shorten the colon length, and reverse the pathological changes of mouse colon. Disulfiram with Cu2+ could not only inhibit the activation of colonic macrophages by blocking NF-KappaB pathway and reducing NLRP3-inflammasome-derived IL-1β secretion and CASP1 activation, but also reduce IL-17 secretion of CD4+ T cells. Moreover, it could protect the intestinal barrier by reversing the expression of tight junction proteins, ZO-1, occludin, and MUC2. Additionally, disulfiram with Cu2+ could reduce the abundance of harmful bacteria and increase that of beneficial bacteria in the intestinal tract of mice, effectively improving the intestinal microecology.
DOI: 10.5281/zenodo.7357686
title: High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics

description: How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from three African countries and identified significant associations across the human leukocyte antigen (HLA) locus for five antigens spanning pertussis, diphtheria and hepatitis B vaccines. Using high-resolution HLA typing in 1,706 individuals from 11 African populations we constructed a continental imputation resource to fine-map signals of association across the class II HLA observing genetic variation explaining up to 10% of the observed variance in antibody responses. Using follicular helper T-cell assays, <em>in silico</em> binding, and immune cell eQTL datasets we find evidence of <em>HLA-DRB1</em> expression correlating with serological response and inferred protection from pertussis following vaccination. This work improves our understanding of molecular mechanisms underlying HLA associations that should support vaccine design and development across Africa with wider global relevance.
description: This dataset contains GWAS summary statistics for eight vaccine antibody responses measured in 2,499 infants from three African counties: Uganda, South Africa and Burkina Faso.
DOI: 10.5281/zenodo.7357687
title: High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics

description: How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from three African countries and identified significant associations across the human leukocyte antigen (HLA) locus for five antigens spanning pertussis, diphtheria and hepatitis B vaccines. Using high-resolution HLA typing in 1,706 individuals from 11 African populations we constructed a continental imputation resource to fine-map signals of association across the class II HLA observing genetic variation explaining up to 10% of the observed variance in antibody responses. Using follicular helper T-cell assays, <em>in silico</em> binding, and immune cell eQTL datasets we find evidence of <em>HLA-DRB1</em> expression correlating with serological response and inferred protection from pertussis following vaccination. This work improves our understanding of molecular mechanisms underlying HLA associations that should support vaccine design and development across Africa with wider global relevance.
description: This dataset contains GWAS summary statistics for eight vaccine antibody responses measured in 2,499 infants from three African counties: Uganda, South Africa and Burkina Faso.
DOI: 10.6073/pasta/4dae939ae08c5c240ab906a2ecb6aeff
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 7 meteorological station: 5-minute summary wind and air temperature data: 2013 - ongoing

description: This data package contains 5-minute air temperature and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-7 met station. Average air temperature, wind speed, and wind direction are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. This is a subset of baseline weather data collected at the 15 Jornada Basin LTER CSIS study blocks, New Mexico. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.6084/m9.figshare.21670376
title: Effects of acupuncture on intestinal microflora and plasma metabolites in type 2 diabetes mellitus mice with insulin resistance

description: Raw data of the figures in our article “Effects of acupuncture on intestinal microflora and plasma metabolites in type 2 diabetes mellitus mice with insulin resistance”
DOI: 10.6084/m9.figshare.21670376.v1
title: Effects of acupuncture on intestinal microflora and plasma metabolites in type 2 diabetes mellitus mice with insulin resistance

description: Raw data of the figures in our article “Effects of acupuncture on intestinal microflora and plasma metabolites in type 2 diabetes mellitus mice with insulin resistance”
DOI: 10.6073/pasta/4769a7740ffbf910634693215706ed21
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 7 meteorological station: 1-hour summary data: 2017 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-7 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.5519/qd.ftsp6r6x
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (2479 records)
DOI: 10.5519/qd.ajermmfc
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1367810 records)
DOI: 10.6073/pasta/44c19b854e60400db70dcc0bfaf884b8
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 7 meteorological station: 30-minute soil volumetric water content data: 2013 - ongoing

description: 30-minute Soil Moisture data at 10 cm at CSIS Block-7. Collection of soil volumetric water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured at 10 cm depth at 3 locations at each of the 4 plots per block. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded every 30 minutes at an automated meteorological station installed at Jornada LTER CSIS Block-7 site. This is an ONGOING dataset.
DOI: 10.6073/pasta/4095f049d765d5cf6d8056ad64b50aa2
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 7 meteorological station: Daily average soil volumetric water content data: 2013 - ongoing

description: Daily Average of 30-minute Soil Volumetric Water Content data at 10 cm at CSIS Block-7. Collection of soil water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured every 30 minutes at 10 cm depth at 3 locations at each of the 4 plots per block and averaged for the daily value. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded at an automated meteorological station installed at Jornada LTER CSIS Block-7 site. This is an ONGOING dataset.
DOI: 10.6073/pasta/8d745e5486f5856d6b8dd98920ef3464
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 7 meteorological station: Daily summary data: 2013 - ongoing

description: This data package contains hourly air temperature, relative humidity, wind speed, wind direction, and precipitation summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-7 met station. Air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.
DOI: 10.6073/pasta/13f4239e8ffbf91f2d415394901f904e
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 8 meteorological station: 30-minute summary data: 2017 - ongoing

description: This data package contains 30-minute air temperature, relative humidity, and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-1 met station. Average air temperature, relative humidity, wind speed, wind direction, and precipitation are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively. This is an ONGOING dataset.
DOI: 10.6084/m9.figshare.19692034.v1
title: EXFOR-based simultaneous evaluation of neutron-induced uranium and plutonium fission cross sections for JENDL-5

description: The neutron-induced fission cross sections were simultaneously evaluated for the JENDL-5 library for <sup>233,235</sup>U and <sup>239,241</sup>Pu from 10 keV to 200 MeV and for <sup>238</sup>U and <sup>240</sup>Pu from 100 keV to 200 MeV. Evaluation was performed by least-squares fitting of Schmittroth’s roof function to the logarithms of the experimental cross sections and cross section ratios in the EXFOR library. A simultaneous evaluation code SOK was used with its extension to data in arbitrary unit. The outputs of the code were adopted as the evaluated cross sections without any further corrections. The newly obtained evaluated cross sections were compared with the evaluated cross sections in the JENDL-4.0 library and the IAEA Neutron Data Standards 2017. The evaluated cross sections were also validated against the californium-252 spontaneous fission neutron spectrum averaged cross sections, ΣΣ (coupled thermal/fast uranium and boron carbide spherical assembly) neutron spectrum averaged cross sections, and small-sized LANL fast system criticalities. The changes in the obtained evaluated cross sections from those in the JENDL-4.0 library are within 4% (<sup>241</sup>Pu), 3% (<sup>233</sup>U, <sup>240</sup>Pu), or 2% (<sup>235</sup>U, <sup>239</sup>Pu). The newly evaluated <sup>235</sup>U, <sup>238</sup>U and <sup>239</sup>Pu cross sections agree with the IAEA Neutron Data Standards 2017 within 2% with some exceptions.
DOI: 10.5281/zenodo.7393128
title: Data to reproduce the results presented in Sehgal et al. 2022. Journal of Geophysical Research Earth Surface, https://doi.org/10.1029/2022JF006838 ("A Generic Relation Between Turbidity, Suspended Particulate Matter Concentration, and Sediment Characteristics")

description: This repository consists data to reproduce results as presented in: "A Generic Relation Between Turbidity, Suspended Particulate Matter Concentration, and Sediment Characteristics", Journal of Geophysical Research Earth Surface. Kindly refer to the readme.text file to navigate through the dataset.
description: The research was funded by the Luxembourg National Research Fund(FNR) (PRIDE15/10623093/HYDRO‐CSI).
description: {"references": ["Sehgal, D., Mart\u00ednez\u2010Carreras, N., Hissler, C., Bense, V. F., & Hoitink, A. J. F. (T). (2022). A generic relation between turbidity, suspended particulate matter concentration and, sediment characteristics. Journal of Geophysical Research: Earth Surface, 127, e2022JF006838."]}
DOI: 10.6073/pasta/a66140f40379a9e67e332eff1a9ecbe8
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 8 meteorological station: 5-minute summary wind and air temperature data: 2013 - ongoing

description: This data package contains 5-minute air temperature and wind summary data from Jornada Basin LTER Cross Scale Interactions Study (CSIS) Block-8 met station. Average air temperature, wind speed, and wind direction are measured and calculated at an automated meteorological station connected to a 900 MHz spread spectrum wireless network. Wind speed is measured at 37cm, 75 cm, 150 cm, and 300 cm, wind direction at approximately 3m, and air temperature and relative humidity at approximate 2.5m. This is a subset of baseline weather data collected at the 15 Jornada Basin LTER CSIS study blocks, New Mexico. Measurements are aggregated at intervals of 5, 30, 60 minutes and daily, with precipitation additionally provided with 1 second aggregation during precipitation events. The met station variables measured include air temperature, precipitation, relative humidity, wind direction, wind speed. Precipitation is not measured at Block 1 and Block 12 because of proximity to Block 2 and Block 13, respectively . This is an ONGOING dataset.