cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16897214.v1
title: Nasal vestibule squamous cell carcinoma: a population-based cohort study from DAHANCA

description: Cancer of the nasal vestibule is a rare type of malignancy dominated by squamous cell carcinoma (SCC), and with poor survival. The treatment is either radiotherapy, surgery or a combination of both. Previous studies have shown a 5-year disease-specific survival of 74% and overall survival (OS) of 50%. Our objective was to describe the consecutive cohort of patients diagnosed with SCC of the nasal vestibule in Denmark from 2008 until 2018 and evaluate prognostic factors and treatment outcome using locoregional failure (LRF), disease-specific mortality (DSM), and OS as endpoints. All patients diagnosed with SCC of the nasal vestibule from 2008 until 2018 were identified in the nationwide clinical database, DAHANCA and were followed for LRF and death (DSM and OS) until March 2021. OS was analysed using Kaplan–Meier estimator, and cumulative incidence of LRF and DSM were analysed using the Aalen–Johansen estimator. Analysis of prognostic factors was performed using Cox proportional hazard models. A total of 162 patients were identified. The median age was 71 years and 54% were male. Disease stage at the time of diagnosis were stage I (70%), II (17%), III (2%) and IV (11%). Curatively intended treatment was performed in 146 patients (90%), of which treatment failure occurred in 42 patients (29%). Most failures occurred at the primary tumour site (64%). Cancer Patient Pathways recommended time to treatment was fulfilled in 71% of patients. The 5-year OS and DSM in patients treated with curative intent were 65% and 11%, respectively. Stage was a significant independent prognostic factor. No difference in LRF, DSM or OS were shown between the applied treatments. Stage is the main independent prognostic factor, and failure most commonly appear at the primary tumour site.
DOI: 10.6084/m9.figshare.16543237.v1
title: Retrospective validation of coverage probability based simultaneous integrated nodal boost in locally advanced cervical cancer: a mono-institutional analysis

description: Retrospective validation of coverage probability based simultaneous integrated nodal boost in locally advanced cervical cancer: a mono-institutional analysis
DOI: 10.6084/m9.figshare.16897214
title: Nasal vestibule squamous cell carcinoma: a population-based cohort study from DAHANCA

description: Cancer of the nasal vestibule is a rare type of malignancy dominated by squamous cell carcinoma (SCC), and with poor survival. The treatment is either radiotherapy, surgery or a combination of both. Previous studies have shown a 5-year disease-specific survival of 74% and overall survival (OS) of 50%. Our objective was to describe the consecutive cohort of patients diagnosed with SCC of the nasal vestibule in Denmark from 2008 until 2018 and evaluate prognostic factors and treatment outcome using locoregional failure (LRF), disease-specific mortality (DSM), and OS as endpoints. All patients diagnosed with SCC of the nasal vestibule from 2008 until 2018 were identified in the nationwide clinical database, DAHANCA and were followed for LRF and death (DSM and OS) until March 2021. OS was analysed using Kaplan–Meier estimator, and cumulative incidence of LRF and DSM were analysed using the Aalen–Johansen estimator. Analysis of prognostic factors was performed using Cox proportional hazard models. A total of 162 patients were identified. The median age was 71 years and 54% were male. Disease stage at the time of diagnosis were stage I (70%), II (17%), III (2%) and IV (11%). Curatively intended treatment was performed in 146 patients (90%), of which treatment failure occurred in 42 patients (29%). Most failures occurred at the primary tumour site (64%). Cancer Patient Pathways recommended time to treatment was fulfilled in 71% of patients. The 5-year OS and DSM in patients treated with curative intent were 65% and 11%, respectively. Stage was a significant independent prognostic factor. No difference in LRF, DSM or OS were shown between the applied treatments. Stage is the main independent prognostic factor, and failure most commonly appear at the primary tumour site.
DOI: 10.48370/ofd/bpjulv
title: Neoërysiphe galeopsidis (DC.) U. Braun, 701

description: Fungarium Micromycetes
DOI: 10.6084/m9.figshare.17807533
title: Target coverage and local recurrences after radiotherapy for sinonasal cancer in Denmark 2008–2015. A DAHANCA study

description: The study aimed to investigate the pattern of failure and describe compromises in the definition and coverage of the target for patients treated with curatively intended radiotherapy (RT) for sinonasal cancer (SNC). Patients treated with curatively intended RT in 2008–2015 in Denmark for SNC were eligible for the retrospective cohort study. Information regarding diagnosis and treatment was retrieved from the national database of the Danish Head and Neck Cancer Group (DAHANCA). Imaging from the diagnosis of recurrences was collected, and the point of origin (PO) of the recurrent tumour was estimated. All treatment plans were collected and reviewed with the focus on target coverage, manual modifications of target volumes, and dose to organs at risk (OARs) above defined constraints. A total of 184 patients were included in the analysis, and 76 (41%) relapsed. The majority of recurrences involved T-site (76%). Recurrence imaging of 39 patients was evaluated, and PO was established. Twenty-nine POs (74%) were located within the CTV, and the minimum dose to the PO was median 64.1 Gy (3.1–70.7). The criteria for target coverage (V95%) was not met in 89/184 (48%) of the CTV and 131/184 (71%) of the PTV. A total of 24% of CTVs had been manually modified to spare OARs of high-dose irradiation. No difference in target volume modifications was observed between patients who suffered recurrence and patients with lasting remission. The majority of relapses after radical treatment of SNC were located in the T-site (the primary tumour site). Multiple compromises with regards to target coverage and tolerance levels for OARs in the sinonasal region, as defined from RT guidelines, were taken. No common practice in this respect could be derived from the study.
DOI: 10.6084/m9.figshare.17807533.v1
title: Target coverage and local recurrences after radiotherapy for sinonasal cancer in Denmark 2008–2015. A DAHANCA study

description: The study aimed to investigate the pattern of failure and describe compromises in the definition and coverage of the target for patients treated with curatively intended radiotherapy (RT) for sinonasal cancer (SNC). Patients treated with curatively intended RT in 2008–2015 in Denmark for SNC were eligible for the retrospective cohort study. Information regarding diagnosis and treatment was retrieved from the national database of the Danish Head and Neck Cancer Group (DAHANCA). Imaging from the diagnosis of recurrences was collected, and the point of origin (PO) of the recurrent tumour was estimated. All treatment plans were collected and reviewed with the focus on target coverage, manual modifications of target volumes, and dose to organs at risk (OARs) above defined constraints. A total of 184 patients were included in the analysis, and 76 (41%) relapsed. The majority of recurrences involved T-site (76%). Recurrence imaging of 39 patients was evaluated, and PO was established. Twenty-nine POs (74%) were located within the CTV, and the minimum dose to the PO was median 64.1 Gy (3.1–70.7). The criteria for target coverage (V95%) was not met in 89/184 (48%) of the CTV and 131/184 (71%) of the PTV. A total of 24% of CTVs had been manually modified to spare OARs of high-dose irradiation. No difference in target volume modifications was observed between patients who suffered recurrence and patients with lasting remission. The majority of relapses after radical treatment of SNC were located in the T-site (the primary tumour site). Multiple compromises with regards to target coverage and tolerance levels for OARs in the sinonasal region, as defined from RT guidelines, were taken. No common practice in this respect could be derived from the study.
DOI: 10.48370/ofd/whe1kn/dgv7lh
title: Neoërysiphe galeopsisdis (DC.) U. Braun F-0695.tif

description: :unav
DOI: 10.48370/ofd/whe1kn
title: Neoërysiphe galeopsidis (DC.) U. Braun, 695

description: Fungarium Micromycetes
DOI: 10.6084/m9.figshare.11283758.v7
title: Global Hydropower Database (GHD) and hydroelectricity production (HP) model

description: 1. GHD comprises 8716 hydropower plants distributed across 134 countries. The detailed description can be found in the Supplementary and the main text of the following article:Wan W, Zhao J, Popat E, Herbert C, Döll P. Analyzing the Impact of Streamflow Drought on Hydroelectricity Production: A Global-Scale Study. Water Resources Research. 2021, 4(57):e2020WR028087.<br><br>We kindly ask users to cite this article in any published material produced using the GHD.<br>2. 0.5° global drainage direction map DDM30 (Döll & Lehner, 2002)3. R script of hydroelectricity production model4. Other .nc file used<br>
DOI: 10.25345/c5z28x
title: MassIVE MSV000088775 - MAM Nature Protocol 2022-chimeric IgG1mAb DP spiked with HCPs
title: Peptide mapping experiment on chimeric Ig1 mAb drug product spiked with spiked with different levels of HCPs, cathepsin and rHLPL, at 3 different levels, 10, 100, and 1000ppm (three replicates are provided for each spiked level as 1, 2, and 3)
DOI: 10.6084/m9.figshare.18865409
title: Reference case 4 - Latent heat due to water content - a concrete block with moisture

description: This file contains the results of Reference case 4 - Latent heat due to water content - a concrete block with moisture verification study. Abaqus was utilized to perform the analysis and the problem and solution method can be found in the "A Scheme for verification of computer codes for calculating temperature in fire exposed structures" by:<br>Ulf Wickstrom<br>Johan Palsson<br><br>
DOI: 10.6084/m9.figshare.18865409.v1
title: Reference case 4 - Latent heat due to water content - a concrete block with moisture

description: This file contains the results of Reference case 4 - Latent heat due to water content - a concrete block with moisture verification study. Abaqus was utilized to perform the analysis and the problem and solution method can be found in the "A Scheme for verification of computer codes for calculating temperature in fire exposed structures" by:<br>Ulf Wickstrom<br>Johan Palsson<br><br>
DOI: 10.6084/m9.figshare.17012114
title: Large-scale standard fire test results of a Profiled steel decking/boarding system (SD system).

description: The SD system tested comprises a VP50 profiled steel decking, with 9 mm Fibre cement boards attached on top and 9 mm Calcium Silicate boards and strips attached to the bottom. The data captured are the temperature measurements using thermocouples throughout the layers of the system. The technical drawings pertaining to the experimental setup can be found in the 'My DATA " tab.
DOI: 10.6084/m9.figshare.17012114.v1
title: Large-scale standard fire test results of a Profiled steel decking/boarding system (SD system).

description: The SD system tested comprises a VP50 profiled steel decking, with 9 mm Fibre cement boards attached on top and 9 mm Calcium Silicate boards and strips attached to the bottom. The data captured are the temperature measurements using thermocouples throughout the layers of the system. The technical drawings pertaining to the experimental setup can be found in the 'My DATA " tab.
DOI: 10.6084/m9.figshare.17012681
title: Large-scale standard fire test results of a novel cellular beam structural system (CBS).

description: The results contained in this data set were obtained from a large scale standard fire test conducted on a novel cellular beam structural (CBS) system with a non-composite profiled steel decking boarding system. The decking boarding system comprises VP50 profiled decking steel with Fibre cement and Calcium Silicate boards attached to the top and bottom. The experimental frame tested consisted of a total of 10 main structural elements, including two cellular beams, two parallel channel beams, two primary I-beams, and four columns. The data collected from the experimental test consists of temperature measurements from thermocouples placed along the decking/boarding system, and the main horizontal structural elements. Furthermore, vertical deflection data was also obtained using linear variable differential transducers placed at various locations along the horizontal structural members. The technical drawings of the experimental setup have also been published.
DOI: 10.6084/m9.figshare.17012681.v1
title: Large-scale standard fire test results of a novel cellular beam structural system (CBS).

description: The results contained in this data set were obtained from a large scale standard fire test conducted on a novel cellular beam structural (CBS) system with a non-composite profiled steel decking boarding system. The decking boarding system comprises VP50 profiled decking steel with Fibre cement and Calcium Silicate boards attached to the top and bottom. The experimental frame tested consisted of a total of 10 main structural elements, including two cellular beams, two parallel channel beams, two primary I-beams, and four columns. The data collected from the experimental test consists of temperature measurements from thermocouples placed along the decking/boarding system, and the main horizontal structural elements. Furthermore, vertical deflection data was also obtained using linear variable differential transducers placed at various locations along the horizontal structural members. The technical drawings of the experimental setup have also been published.
DOI: 10.5258/soton/d2123
title: Dataset for 'Personality-dependent passage behaviour of an aquatic invasive species at a barrier to dispersal'

description: Data associated with article 'Personality-dependent passage behaviour of an aquatic invasive species at a barrier to dispersal'.
DOI: 10.5281/zenodo.5869738
title: Korean embedding files using the different morphological segmentation granularity of the word

description: Embedding files using the following segmentation: wordUD morphUD +morphUD Based on wordUD there are 9,692,938 sentences and 157,653,628 words (tokenized) including all articles published in The Hankyoreh during 2016 (1.2M sentences), Sejong morphologically analyzed corpus (3M), and Korean Wiki (20201101) (5.3M): ./fasttext skipgram -input input -output embedding -dim 300
DOI: 10.5281/zenodo.5869737
title: Korean embedding files using the different morphological segmentation granularity of the word

description: Embedding files using the following segmentation: wordUD morphUD +morphUD Based on wordUD there are 9,692,938 sentences and 157,653,628 words (tokenized) including all articles published in The Hankyoreh during 2016 (1.2M sentences), Sejong morphologically analyzed corpus (3M), and Korean Wiki (20201101) (5.3M): ./fasttext skipgram -input input -output embedding -dim 300
DOI: 10.6084/m9.figshare.19114688
title: codes for "Dynamic-quenching of a single-photon avalanche photodetector using an adaptive resistive switch"

description: codes
DOI: 10.6084/m9.figshare.17099855
title: Supplementary Material for: Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain

description: Background Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder characterized by high androgen levels. The aim of this study was to evaluate the effects of hyperandrogenism on the hypothalamus, and subsequently on the food intake and obesity in females. Methods A dihydroxy testosterone (DHT)-induced rat model was established to recapitulate the hyperandrogenism features of PCOS patients. Body weight and food intake of the rats were recorded. The food intake of DHT-induced rats was restricted by pair feeding to exclude possible effects of weight gain on the hypothalamus. The expression levels of relevant proteins and mRNAs in the hypothalamus, primary hypothalamic neurons exposed to DHT were analyzed by Western blotting and RT-PCR respectively. The leptin levels in serum and cerebrospinal fluid (CSF) were measured, and leptin was injected via the intracerebroventricular (ICV) route to test the leptin sensitivity of hypothalamus. Results The excessive pre-puberty androgen levels in the DHT-induced rats markedly elevated food intake prior to weight gain. Consistent with this, the expression of NPY and Agouti-related peptide (Agrp) mRNAs were up-regulated, which occurred prior to obesity and even with restricted food intake. In addition, the hypothalamic sensitivity to insulin and leptin was also impaired in the DHT-induced rats before obesity and with restricted food intake. DHT significantly reduced the leptin levels in the CSF, and ICV injection of leptin inhibited the DHT-induced increase in food intake. Conclusions Androgen excess increased food intake in rats and promoted obesity by down-regulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the CSF.
DOI: 10.6084/m9.figshare.17099855.v1
title: Supplementary Material for: Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain

description: Background Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder characterized by high androgen levels. The aim of this study was to evaluate the effects of hyperandrogenism on the hypothalamus, and subsequently on the food intake and obesity in females. Methods A dihydroxy testosterone (DHT)-induced rat model was established to recapitulate the hyperandrogenism features of PCOS patients. Body weight and food intake of the rats were recorded. The food intake of DHT-induced rats was restricted by pair feeding to exclude possible effects of weight gain on the hypothalamus. The expression levels of relevant proteins and mRNAs in the hypothalamus, primary hypothalamic neurons exposed to DHT were analyzed by Western blotting and RT-PCR respectively. The leptin levels in serum and cerebrospinal fluid (CSF) were measured, and leptin was injected via the intracerebroventricular (ICV) route to test the leptin sensitivity of hypothalamus. Results The excessive pre-puberty androgen levels in the DHT-induced rats markedly elevated food intake prior to weight gain. Consistent with this, the expression of NPY and Agouti-related peptide (Agrp) mRNAs were up-regulated, which occurred prior to obesity and even with restricted food intake. In addition, the hypothalamic sensitivity to insulin and leptin was also impaired in the DHT-induced rats before obesity and with restricted food intake. DHT significantly reduced the leptin levels in the CSF, and ICV injection of leptin inhibited the DHT-induced increase in food intake. Conclusions Androgen excess increased food intake in rats and promoted obesity by down-regulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the CSF.
DOI: 10.6084/m9.figshare.17698019
title: Supplementary Material for: Papillary craniopharyngioma: a type of tumor primarily impairing the hypothalamus. A comprehensive anatomo-clinical characterization of 350 well-described cases

description: Objective: Papillary craniopharyngiomas (PCPs) represent a rare histological variant of craniopharyngiomas (CPs) usually involving the hypothalamus. This study systematically analyzes the clinical-anatomical correlation between tumor topography and symptoms related to hypothalamic dysfunction in the largest series of PCPs ever gathered. Methods: From 5,346 CP reports published from 1856 to 2021, we selected 350 well-described cases of the squamous-papillary type. Clinical presentation, tumor topography, severity of hypothalamic adhesion, patient outcome and tumor recurrence were thoroughly analyzed. Results: PCPs predominantly occur in adult (96.3%), male (61.7%) patients presenting with headache (63.4%), visual alterations (56.2%) and psychiatric disturbances (50.4%). Most PCPs are solid (50%), round (50%) lesions that occupy the third ventricle (3V, 94.8%) and show low-risk severity adhesions to the hypothalamus (66.8%). Two major topographical categories can be found: strictly 3V (57.5%), growing above an intact 3V floor (3VF) and not-strictly or infundibulo-tuberal (32.9%), expanding at the infundibulum and/or tuber cinereum. The hypothalamic syndrome predominated among strictly 3V PCPs (p&lt;0.001). Psychiatric symptoms (p&lt;0.001) and high-risk hypothalamic attachments (p=0.031) related to unfavorable postoperative outcomes among patients treated from 2006 onwards. The not-strictly 3V topography was identified as the major predictor of high-risk hypothalamic attachments (71.2% correctly predicted), which, along with incomplete tumor removal (p=0.018), underlies the higher tumor recurrence of this topography (p=0.001). Conclusions: This systematic review evidences that PCP topography is a major determinant of hypothalamic-related symptoms, type of hypothalamic attachments and tumor recurrence rate. Accurate preoperative definition of PCP-hypothalamus relationships is essential for the judicious, safe management of these complex lesions.
DOI: 10.6084/m9.figshare.17698019.v1
title: Supplementary Material for: Papillary craniopharyngioma: a type of tumor primarily impairing the hypothalamus. A comprehensive anatomo-clinical characterization of 350 well-described cases

description: Objective: Papillary craniopharyngiomas (PCPs) represent a rare histological variant of craniopharyngiomas (CPs) usually involving the hypothalamus. This study systematically analyzes the clinical-anatomical correlation between tumor topography and symptoms related to hypothalamic dysfunction in the largest series of PCPs ever gathered. Methods: From 5,346 CP reports published from 1856 to 2021, we selected 350 well-described cases of the squamous-papillary type. Clinical presentation, tumor topography, severity of hypothalamic adhesion, patient outcome and tumor recurrence were thoroughly analyzed. Results: PCPs predominantly occur in adult (96.3%), male (61.7%) patients presenting with headache (63.4%), visual alterations (56.2%) and psychiatric disturbances (50.4%). Most PCPs are solid (50%), round (50%) lesions that occupy the third ventricle (3V, 94.8%) and show low-risk severity adhesions to the hypothalamus (66.8%). Two major topographical categories can be found: strictly 3V (57.5%), growing above an intact 3V floor (3VF) and not-strictly or infundibulo-tuberal (32.9%), expanding at the infundibulum and/or tuber cinereum. The hypothalamic syndrome predominated among strictly 3V PCPs (p&lt;0.001). Psychiatric symptoms (p&lt;0.001) and high-risk hypothalamic attachments (p=0.031) related to unfavorable postoperative outcomes among patients treated from 2006 onwards. The not-strictly 3V topography was identified as the major predictor of high-risk hypothalamic attachments (71.2% correctly predicted), which, along with incomplete tumor removal (p=0.018), underlies the higher tumor recurrence of this topography (p=0.001). Conclusions: This systematic review evidences that PCP topography is a major determinant of hypothalamic-related symptoms, type of hypothalamic attachments and tumor recurrence rate. Accurate preoperative definition of PCP-hypothalamus relationships is essential for the judicious, safe management of these complex lesions.