cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5793876.v1
title: Real-time freehand 3D ultrasound imaging

description: Real-time freehand 3D ultrasound (US) has attracted much attention in clinical practices because it provides interactive feedback to help the clinicians acquire not only high-quality images but also timely information of the scanning area, which is necessary in intraoperative examinations. In this study, we developed a real-time freehand 3D US imaging system which can obtain volume reconstruction and visualisation during data acquisition at real-time level. Based on two popular algorithms, i.e. squared distance weighted interpolation (SDW) and Bezier interpolation, we designed corresponding parallel computing methods that were implemented on the graphics processing unit (GPU) to incrementally reconstruct and display the tissues being scanned using Visualisation toolkits (VTK). With a typical B-scan image size of 302 × 268 at an acquisition rate of 25 Hz and a preset volume size of 90 × 81 × 192, the system achieved an incremental reconstruction-visualisation rate of up to 32 frames/s and 119 frames/s for the SDW and Bezier algorithms, respectively, achieving the real-time 3D US.
DOI: 10.6084/m9.figshare.12085311
title: Additional file 3 of Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression

description: Additional file 3: Table S1. The results of circRNAs array for lung adenocarcinoma tissues and adjacent normal tissues.
DOI: 10.6084/m9.figshare.12085311.v1
title: Additional file 3 of Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression

description: Additional file 3: Table S1. The results of circRNAs array for lung adenocarcinoma tissues and adjacent normal tissues.
DOI: 10.6084/m9.figshare.20473970
title: Hybrid three-dimensional modelling for reservoir fluorescent dissolved organic matter risk assessment

description: A coupled data-driven and 3-dimensional (3D) process-based fluorescent dissolved organic matter (fDOM) prediction model was developed for a shallow, subtropical Australian reservoir. The extent to which reservoir water volume, inflow, and wind conditions affect the fDOM transport dynamics during cyclonic weather events was assessed through scenario analysis and a data-driven Bayesian network (BN) approach. The analysis shows that (a) inflow plumes are the main sources of fDOM during heavy rainfall; (b) the concentration of fDOM near the dam wall is related to rainfall intensity; (c) higher reservoir volumes reduce the rate of increase and peak of fDOM concentration during rainfall events; and (d) fDOM transport to the dam wall is strongly influenced by the prevailing wind direction. A naïve BN developed for fDOM assessment displayed a strong sensitivity of the peak fDOM value to rainfall-related characteristics while the lag time between rainfall event and fDOM peak at the dam wall was highly sensitive to reservoir water volume and wind speed. The hybrid modelling approach provides both new information on 3D fDOM transport in reservoirs during extreme weather events through the model application and an easy-to-interpret, instantaneous modelling output for treatment operators through the BN modelling component. The BN modelling is an essential addition for water treatment operators to promptly predict the impacts of extreme weather events and proactively adjust treatment operations without the computational time burden of a 3D process-based model.
DOI: 10.6084/m9.figshare.20473970.v1
title: Hybrid three-dimensional modelling for reservoir fluorescent dissolved organic matter risk assessment

description: A coupled data-driven and 3-dimensional (3D) process-based fluorescent dissolved organic matter (fDOM) prediction model was developed for a shallow, subtropical Australian reservoir. The extent to which reservoir water volume, inflow, and wind conditions affect the fDOM transport dynamics during cyclonic weather events was assessed through scenario analysis and a data-driven Bayesian network (BN) approach. The analysis shows that (a) inflow plumes are the main sources of fDOM during heavy rainfall; (b) the concentration of fDOM near the dam wall is related to rainfall intensity; (c) higher reservoir volumes reduce the rate of increase and peak of fDOM concentration during rainfall events; and (d) fDOM transport to the dam wall is strongly influenced by the prevailing wind direction. A naïve BN developed for fDOM assessment displayed a strong sensitivity of the peak fDOM value to rainfall-related characteristics while the lag time between rainfall event and fDOM peak at the dam wall was highly sensitive to reservoir water volume and wind speed. The hybrid modelling approach provides both new information on 3D fDOM transport in reservoirs during extreme weather events through the model application and an easy-to-interpret, instantaneous modelling output for treatment operators through the BN modelling component. The BN modelling is an essential addition for water treatment operators to promptly predict the impacts of extreme weather events and proactively adjust treatment operations without the computational time burden of a 3D process-based model.
DOI: 10.6084/m9.figshare.14706847
title: Genomic divergence during artificial selection by feed conversion ratio in Pekin ducks

description: Pekin ducks are world-famous for its fast growth and have become the majority of breeds rearing in duck industry. Feed conversion ratio (FCR) is an important trait in Pekin ducks breeding and production, and the underlying biological processes are complex. To gain an insight to the possible biological mechanism underlying the FCR in Pekin ducks, an artificial selection population (S) and a natural population (Z7) were used in this study. The FCR of S line decreased from 2.184 ± 0.057 in the first generation to 1.886 ± 0.063 in the eighth generation, which displays significantly low FCR (<i>p</i> = 0.0032) than that of the Z7 line (2.23 ± 0.046). Then, 9 samples from eighth generation of S line and 10 samples from Z7 were used for whole-genome resequencing. Analyses of F<sub>ST</sub>, θπ and XP-EHH revealed 450, 479 and 356 candidate genes, which involved in 1,955, 1,933 and 1,964 candidate divergent regions (CDRs), respectively. And the integration of three approaches resulted in 30 overlapping genes. Functional analysis of 30 candidate genes revealed that variants of KCNQ1 and ADCY7, which were involved in the pancreatic secretion signal pathway, could be important molecular markers for high feed conversion efficiency in S line breeding.
DOI: 10.6084/m9.figshare.14706847.v1
title: Genomic divergence during artificial selection by feed conversion ratio in Pekin ducks

description: Pekin ducks are world-famous for its fast growth and have become the majority of breeds rearing in duck industry. Feed conversion ratio (FCR) is an important trait in Pekin ducks breeding and production, and the underlying biological processes are complex. To gain an insight to the possible biological mechanism underlying the FCR in Pekin ducks, an artificial selection population (S) and a natural population (Z7) were used in this study. The FCR of S line decreased from 2.184 ± 0.057 in the first generation to 1.886 ± 0.063 in the eighth generation, which displays significantly low FCR (<i>p</i> = 0.0032) than that of the Z7 line (2.23 ± 0.046). Then, 9 samples from eighth generation of S line and 10 samples from Z7 were used for whole-genome resequencing. Analyses of F<sub>ST</sub>, θπ and XP-EHH revealed 450, 479 and 356 candidate genes, which involved in 1,955, 1,933 and 1,964 candidate divergent regions (CDRs), respectively. And the integration of three approaches resulted in 30 overlapping genes. Functional analysis of 30 candidate genes revealed that variants of KCNQ1 and ADCY7, which were involved in the pancreatic secretion signal pathway, could be important molecular markers for high feed conversion efficiency in S line breeding.
DOI: 10.6084/m9.figshare.24144076
title: Additional file 2 of Chromosome constitution and genetic relationships of Morus spp. revealed by genomic in situ hybridization

description: Additional file 2: Supplementary Table 1. List of the mulberry accessions used in this study.
DOI: 10.6084/m9.figshare.24144076.v1
title: Additional file 2 of Chromosome constitution and genetic relationships of Morus spp. revealed by genomic in situ hybridization

description: Additional file 2: Supplementary Table 1. List of the mulberry accessions used in this study.
DOI: 10.6084/m9.figshare.19425504
title: Regulation of STUB1 expression and its biological significance in mouse Sertoli cells

description: STIP1 Homology and U-Box Containing Protein 1 (STUB1), a ubiquitin E3 ligase initially involved in immune responses, has recently emerged as a pleiotropic regulator of different biological systems, including skeletal and male reproduction systems. On the latter, a homozygous mutation in the <i>STUB1</i> gene has been identified in patients with hypogonadism. However, the pattern of expression and biological actions of STUB1 in testis remains so far unexplored. Herein, we report analyses on the testicular expression of STUB1 in human testes with impaired spermatogenesis and paracrine regulation of STUB1 expression in mouse testis development and the direct effects of ablation STUB1 on Sertoli cell (SC) functions. STUB1 was expressed abundantly in pachytene spermatocytes and SCs, and weakly in spermatogonia and differentiating spermatids in normal human testis. In contrast, Sertoli-specific expression of STUB1 was significantly decreased in the human testes with impaired spermatogenesis. Throughout postnatal development of mouse testis, however, STUB1 was expressed exclusively in the nuclei of the functionally mature SCs. The adjacent germ cell (GC)-derived IL-1α overtly regulated STUB1 expression through promoting the ETS domain transcription factor Elk-1 (ELK1)-mediated transactivation. Importantly, ablation of endogenous STUB1 caused lipid accumulation and senescence in GC co-incubated SCs. Together with previous reports on the stimulatory effects of IL-1α on cell senescence, our findings suggest that STUB1 may serve as an important negative feedback signaling to modulate the magnitude of GCs-derived IL-1α, which is normally maintained at low levels within testis.
DOI: 10.6084/m9.figshare.19425504.v1
title: Regulation of STUB1 expression and its biological significance in mouse Sertoli cells

description: STIP1 Homology and U-Box Containing Protein 1 (STUB1), a ubiquitin E3 ligase initially involved in immune responses, has recently emerged as a pleiotropic regulator of different biological systems, including skeletal and male reproduction systems. On the latter, a homozygous mutation in the <i>STUB1</i> gene has been identified in patients with hypogonadism. However, the pattern of expression and biological actions of STUB1 in testis remains so far unexplored. Herein, we report analyses on the testicular expression of STUB1 in human testes with impaired spermatogenesis and paracrine regulation of STUB1 expression in mouse testis development and the direct effects of ablation STUB1 on Sertoli cell (SC) functions. STUB1 was expressed abundantly in pachytene spermatocytes and SCs, and weakly in spermatogonia and differentiating spermatids in normal human testis. In contrast, Sertoli-specific expression of STUB1 was significantly decreased in the human testes with impaired spermatogenesis. Throughout postnatal development of mouse testis, however, STUB1 was expressed exclusively in the nuclei of the functionally mature SCs. The adjacent germ cell (GC)-derived IL-1α overtly regulated STUB1 expression through promoting the ETS domain transcription factor Elk-1 (ELK1)-mediated transactivation. Importantly, ablation of endogenous STUB1 caused lipid accumulation and senescence in GC co-incubated SCs. Together with previous reports on the stimulatory effects of IL-1α on cell senescence, our findings suggest that STUB1 may serve as an important negative feedback signaling to modulate the magnitude of GCs-derived IL-1α, which is normally maintained at low levels within testis.
DOI: 10.24403/jp.1341909
title: Bestandssituation von Halophyten an salzhaltigen Rückstandshalden der Kaliindustrie (Kalihalden) in Thüringen / Eckhard Garve
DOI: 10.6084/m9.figshare.14182682
title: Usefulness of the B-Type Natriuretic Peptides in Low Ejection Fraction, Low-Flow, Low-Gradient Aortic Stenosis Results from the TOPAS Multicenter Prospective Cohort Study

description: <b>Background</b>: Patients with low left ventricular ejection fraction (LVEF), low-flow, low-gradient (i.e. classical low flow [CLF]) aortic stenosis (AS) have a dismal short-term outcome without aortic valve replacement (AVR) but high operative mortality. We hypothesized that brain natriuretic peptides (BNP/NT-proBNP) can risk stratify patients with CLF AS and may assist in clinical decision-making. <b>Methods</b>: Patients with aortic valve area ≤1.2 cm<sup>2</sup>, mean transvalvular gradient &lt;40 mmHg, and left ventricular ejection fraction &lt;50%, were prospectively recruited. BNP and/or NT-proBNP were measured at baseline. <b>Results</b>: Among 234 patients (77 [68–83] years, 76% male), BNP &gt; 550 pg/ml or NT-proBNP &gt; 1,600 pg/ml (85% and 93% sensitivity, respectively, to correctly classify 1-year death) strongly predicted all-cause mortality (adjusted HR = 2.53 [1.68–3.81], <i>p</i> &lt; 0.001) outperforming flow reserve and baseline LVEF (all likelihood ratio p ≤ 0.02). For both natriuretic peptides, spline curve analysis showed gradual increase in mortality with higher biomarkers levels, which was blunted by AVR. In a head-to-head comparison (n = 104), NT-proBNP appeared to have superior incremental prognostic value than BNP (likelihood-ratio <i>p</i> &lt; 0.001 vs. <i>p</i> = 0.07). Baseline NT-proBNP ≥ 1,600 pg/ml or BNP ≥ 550 pg/ml, identified: i) a high-risk cohort with a dismal outcome under conservative management, but a markedly better survival associated with early AVR (adjusted HR = 0.41 [0.25–0.65], <i>p</i> &lt; 0.001); and ii) a low-risk cohort with an excellent 1-year survival (94 ± 4%) with conservative management or deferred AVR. <b>Conclusion</b>: In patients with CLF AS, BNP/NT-proBNP have the potential to identify high-risk patients who may benefit from early AVR.
DOI: 10.6084/m9.figshare.14182682.v2
title: Usefulness of the B-Type Natriuretic Peptides in Low Ejection Fraction, Low-Flow, Low-Gradient Aortic Stenosis Results from the TOPAS Multicenter Prospective Cohort Study

description: <b>Background</b>: Patients with low left ventricular ejection fraction (LVEF), low-flow, low-gradient (i.e. classical low flow [CLF]) aortic stenosis (AS) have a dismal short-term outcome without aortic valve replacement (AVR) but high operative mortality. We hypothesized that brain natriuretic peptides (BNP/NT-proBNP) can risk stratify patients with CLF AS and may assist in clinical decision-making. <b>Methods</b>: Patients with aortic valve area ≤1.2 cm<sup>2</sup>, mean transvalvular gradient &lt;40 mmHg, and left ventricular ejection fraction &lt;50%, were prospectively recruited. BNP and/or NT-proBNP were measured at baseline. <b>Results</b>: Among 234 patients (77 [68–83] years, 76% male), BNP &gt; 550 pg/ml or NT-proBNP &gt; 1,600 pg/ml (85% and 93% sensitivity, respectively, to correctly classify 1-year death) strongly predicted all-cause mortality (adjusted HR = 2.53 [1.68–3.81], <i>p</i> &lt; 0.001) outperforming flow reserve and baseline LVEF (all likelihood ratio p ≤ 0.02). For both natriuretic peptides, spline curve analysis showed gradual increase in mortality with higher biomarkers levels, which was blunted by AVR. In a head-to-head comparison (n = 104), NT-proBNP appeared to have superior incremental prognostic value than BNP (likelihood-ratio <i>p</i> &lt; 0.001 vs. <i>p</i> = 0.07). Baseline NT-proBNP ≥ 1,600 pg/ml or BNP ≥ 550 pg/ml, identified: i) a high-risk cohort with a dismal outcome under conservative management, but a markedly better survival associated with early AVR (adjusted HR = 0.41 [0.25–0.65], <i>p</i> &lt; 0.001); and ii) a low-risk cohort with an excellent 1-year survival (94 ± 4%) with conservative management or deferred AVR. <b>Conclusion</b>: In patients with CLF AS, BNP/NT-proBNP have the potential to identify high-risk patients who may benefit from early AVR.
DOI: 10.6084/m9.figshare.14182682.v1
title: Usefulness of the B-Type Natriuretic Peptides in Low Ejection Fraction, Low-Flow, Low-gradient Aortic Stenosis Results from the TOPAS Multicenter Prospective Cohort Study

description: Patients with low ejection fraction, low-flow, low-gradient (i.e. Classical low flow [CLF]) aortic stenosis (AS) have a dismal short-term outcome without aortic valve replacement (AVR) but high operative mortality. We hypothesized that brain natriuretic peptides (BNP/NT-proBNP) can risk stratify patients with CLF AS and may assist in clinical decision making. Patients with aortic valve area ≤1.2 cm<sup>2</sup>, mean transvalvular gradient &lt;40 mmHg, and left ventricular ejection fraction &lt;50%, were prospectively recruited. BNP and/or NT-proBNP were measured at baseline. Among 234 patients (77[68-83] years, 76% males), BNP &gt;550 pg/ml or NT-proBNP &gt;1,600 pg/ml (85% and 93% sensitivity, respectively to correctly classify 1-year death) strongly predicted all-cause mortality (adjusted HR=2.53 [1.68-3.81], p&lt;0.001) outperforming flow reserve and baseline LVEF (all likelihood ratio p≤0.02). For both natriuretic peptides, spline curve analysis showed gradual increase in mortality with higher biomarkers levels, which was blunted by AVR. In a head-to-head comparison (n=104), NT-proBNP appeared to have superior incremental prognostic value than BNP (likelihood-ratio p&lt;0.001 vs. p=0.07). Baseline NT-proBNP ≥1,600 pg/ml or BNP ≥550 pg/ml, identified: i) a high-risk cohort with a dismal outcome under conservative management, but a markedly better survival associated with early AVR (adjusted HR=0.41[0.25-0.65], p&lt;0.001); and ii) a low-risk cohort with an excellent 1-year survival (94±4%) with conservative management or deferred AVR. : In patients with CLF AS, BNP/NT-proBNP have the potential to identify high-risk patients who may benefit from early AVR. NCT01835028. <b>HTTPS://CLINICALTRIALS.GOV/CT2/SHOW/NCT01835028</b>
DOI: 10.6084/m9.figshare.12085557
title: A new mixed-ligand coordination polymer: crystal structure and protective effect on viral myocarditis via regulating inflammatory response <i>in vivo</i>

description: A new Co(II)-based coordination polymer {[Co(ttpa)(1,4-bdc)]·H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>) as well as its nanoparticles (denoted as nano <b>1</b> hereafter) have been synthesized using hydrothermal and hand grinding methods (ttpa = tris(4-(1,2,4-triazol-1-yl)phenyl)amine, 1,4-bdc = 1,4-benzenedicarboxylate). Furthermore, the protective effect of nano <b>1</b> on acute viral myocarditis mice was evaluated. Firstly, the CVB3-induced acute viral myocarditis model was successfully constructed and then nano <b>1</b> was given for indicated treatment. The <i>in vivo</i> activity of nano <b>1</b> was evaluated with mice survival rate and the CVB3 titer determination. The level of the inflammatory cytokines in the mice after treatment was measured with enzyme linked immunosorbent assay (ELISA) detection kit.
DOI: 10.6084/m9.figshare.12085557.v2
title: A new mixed-ligand coordination polymer: crystal structure and protective effect on viral myocarditis via regulating inflammatory response <i>in vivo</i>

description: A new Co(II)-based coordination polymer {[Co(ttpa)(1,4-bdc)]·H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>) as well as its nanoparticles (denoted as nano <b>1</b> hereafter) have been synthesized using hydrothermal and hand grinding methods (ttpa = tris(4-(1,2,4-triazol-1-yl)phenyl)amine, 1,4-bdc = 1,4-benzenedicarboxylate). Furthermore, the protective effect of nano <b>1</b> on acute viral myocarditis mice was evaluated. Firstly, the CVB3-induced acute viral myocarditis model was successfully constructed and then nano <b>1</b> was given for indicated treatment. The <i>in vivo</i> activity of nano <b>1</b> was evaluated with mice survival rate and the CVB3 titer determination. The level of the inflammatory cytokines in the mice after treatment was measured with enzyme linked immunosorbent assay (ELISA) detection kit.
DOI: 10.6084/m9.figshare.12085557.v1
title: A new mixed-ligand coordination polymer: crystal structure and protective effect on viral myocarditis via regulating inflammatory response <i>in vivo</i>

description: A new Co(II)-based coordination polymer {[Co(ttpa)(1,4-bdc)]·H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>) as well as its nanoparticles (denoted as nano <b>1</b> hereafter) have been synthesized using hydrothermal and hand grinding methods (ttpa = tris(4-(1,2,4-triazol-1-yl)phenyl)amine, 1,4-bdc = 1,4-benzenedicarboxylate). Furthermore, the protective effect of nano <b>1</b> on acute viral myocarditis mice was evaluated. Firstly, the CVB3-induced acute viral myocarditis model was successfully constructed and then nano <b>1</b> was given for indicated treatment. The <i>in vivo</i> activity of nano <b>1</b> was evaluated with mice survival rate and the CVB3 titer determination. The level of the inflammatory cytokines in the mice after treatment was measured with enzyme linked immunosorbent assay (ELISA) detection kit.
DOI: 10.6084/m9.figshare.19425665
title: Near-real-time daily estimates of CO2 emissions from 1500 cities worldwide

description: A daily city-level dataset of fossil fuel and cement CO2 emissions. It provides daily, city-level estimates of emissions from January 2019 through December 2021 for 1500 cities in 46 countries, and disaggregates five sectors: power generation, residential (buildings), industry, ground transportation, and aviation. The goal of this dataset is to improve the timeliness and temporal resolution of city-level emission inventories and includes estimates for both functional urban areas and city administrative areas that are consistent with global and regional totals. It also provides the first estimates for many cities in low-income countries. Such near-real-time CO2 dataset would be of great advantage to further monitoring the human activities and to capture the impacts of COVID-19 for long term.<br><br>Latest Dataset for:Carbon Monitor Cities, near-real-time daily estimates of CO2 emissions from 1500 cities worldwide