cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14350475
title: Supplementary Material for: MiR-22-3p Suppresses Vascular Remodeling and Oxidative Stress by Targeting CHD9 during the Development of Hypertension

description: Hypertension is considered a risk factor for a series of systematic diseases. Known factors including genetic predisposition, age, and diet habits are strongly associated with the initiation of hypertension. The current study aimed to investigate the role of miR-22-3p in hypertension. In this study, we discovered that the miR-22-3p level was significantly decreased in the thoracic aortic vascular tissues and aortic smooth muscle cells (ASMCs) of spontaneously hypertensive rats. Functionally, the overexpression of miR-22-3p facilitated the switch of ASMCs from the synthetic to contractile phenotype. To investigate the underlying mechanism, we predicted 11 potential target mRNAs for miR-22-3p. After screening, chromodomain helicase DNA-binding 9 (CHD9) was validated to bind with miR-22-3p. Rescue assays showed that the co-overexpression of miR-22-3p and CHD9 reversed the inhibitory effect of miR-22-3p mimics on cell proliferation, migration, and oxidative stress in ASMCs. Finally, miR-22-3p suppressed vascular remodeling and oxidative stress in vivo. Overall, miR-22-3p regulated ASMC phenotype switch by targeting CHD9. This new discovery provides a potential insight into hypertension treatment.
DOI: 10.6084/m9.figshare.14350475.v1
title: Supplementary Material for: MiR-22-3p Suppresses Vascular Remodeling and Oxidative Stress by Targeting CHD9 during the Development of Hypertension

description: Hypertension is considered a risk factor for a series of systematic diseases. Known factors including genetic predisposition, age, and diet habits are strongly associated with the initiation of hypertension. The current study aimed to investigate the role of miR-22-3p in hypertension. In this study, we discovered that the miR-22-3p level was significantly decreased in the thoracic aortic vascular tissues and aortic smooth muscle cells (ASMCs) of spontaneously hypertensive rats. Functionally, the overexpression of miR-22-3p facilitated the switch of ASMCs from the synthetic to contractile phenotype. To investigate the underlying mechanism, we predicted 11 potential target mRNAs for miR-22-3p. After screening, chromodomain helicase DNA-binding 9 (CHD9) was validated to bind with miR-22-3p. Rescue assays showed that the co-overexpression of miR-22-3p and CHD9 reversed the inhibitory effect of miR-22-3p mimics on cell proliferation, migration, and oxidative stress in ASMCs. Finally, miR-22-3p suppressed vascular remodeling and oxidative stress in vivo. Overall, miR-22-3p regulated ASMC phenotype switch by targeting CHD9. This new discovery provides a potential insight into hypertension treatment.
DOI: 10.6084/m9.figshare.14350478
title: Supplementary Material for: Incidence Estimates of Perinatal Arterial Ischemic Stroke in Preterm- and Term-Born Infants: A National Capture-Recapture Calculation Corrected Surveillance Study

description: <b><i>Introduction:</i></b> Data on valid incidence estimates of perinatal arterial ischemic stroke (PAIS) are scarce. This analysis aims to determine incidence of PAIS in term- and preterm-born infants and to investigate clinical differences related to prematurity. <b><i>Methods:</i></b> This surveillance study (2015–2017) in all German paediatric hospital estimated incidences for MRI-confirmed PAIS in term and preterm infants. To correct for under-reporting, we performed capture-recapture-calculations (CRC) in the most populous federal state and extrapolated nationwide. Differences in clinical presentation in term- and preterm-born infants were assessed. <b><i>Results:</i></b> 126 term- and 19 preterm-born infants with PAIS were reported. CRC corrected incidence of PAIS was 22 (95% confidence interval [CI] 17, 27) per 100,000 live births. Stratified by prematurity, the incidence was 32 (95% CI 15, 49) per 100,000 in preterm-born infants and 21 (95% CI 16, 26) per 100,000 term-born infants (significant difference <i>p</i> = 0.001). In symptomatic cases only (<i>n</i> = 120 term born, <i>n</i> = 12 preterm born), incidences did not differ. Risk factor patterns were similar, but number of risk factors in preterm babies was elevated (mean 3.8 vs. 2.9; <i>p</i> = 0.01) and median age at diagnosis was increased (5 vs. 3 days; <i>p</i> = 0.04). Clinical seizures were observed in 88% (106/120) of symptomatic term infants compared to 33% (4/12) in preterm-born infants (<i>p</i> &lt; 0.0001). <b><i>Conclusion:</i></b> PAIS incidence rates in Germany, extrapolated from estimates for completeness of reporting in the largest federal state, were within the range of other population-based studies. As a novel finding, we detected symptomatic PAIS in preterm-born infants to be as common as in term-born infants although their symptoms were often unspecific.
DOI: 10.6084/m9.figshare.14350478.v1
title: Supplementary Material for: Incidence Estimates of Perinatal Arterial Ischemic Stroke in Preterm- and Term-Born Infants: A National Capture-Recapture Calculation Corrected Surveillance Study

description: <b><i>Introduction:</i></b> Data on valid incidence estimates of perinatal arterial ischemic stroke (PAIS) are scarce. This analysis aims to determine incidence of PAIS in term- and preterm-born infants and to investigate clinical differences related to prematurity. <b><i>Methods:</i></b> This surveillance study (2015–2017) in all German paediatric hospital estimated incidences for MRI-confirmed PAIS in term and preterm infants. To correct for under-reporting, we performed capture-recapture-calculations (CRC) in the most populous federal state and extrapolated nationwide. Differences in clinical presentation in term- and preterm-born infants were assessed. <b><i>Results:</i></b> 126 term- and 19 preterm-born infants with PAIS were reported. CRC corrected incidence of PAIS was 22 (95% confidence interval [CI] 17, 27) per 100,000 live births. Stratified by prematurity, the incidence was 32 (95% CI 15, 49) per 100,000 in preterm-born infants and 21 (95% CI 16, 26) per 100,000 term-born infants (significant difference <i>p</i> = 0.001). In symptomatic cases only (<i>n</i> = 120 term born, <i>n</i> = 12 preterm born), incidences did not differ. Risk factor patterns were similar, but number of risk factors in preterm babies was elevated (mean 3.8 vs. 2.9; <i>p</i> = 0.01) and median age at diagnosis was increased (5 vs. 3 days; <i>p</i> = 0.04). Clinical seizures were observed in 88% (106/120) of symptomatic term infants compared to 33% (4/12) in preterm-born infants (<i>p</i> &lt; 0.0001). <b><i>Conclusion:</i></b> PAIS incidence rates in Germany, extrapolated from estimates for completeness of reporting in the largest federal state, were within the range of other population-based studies. As a novel finding, we detected symptomatic PAIS in preterm-born infants to be as common as in term-born infants although their symptoms were often unspecific.
DOI: 10.6084/m9.figshare.14350544
title: Supplementary Material for: Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential

description: <b><i>Background:</i></b> Progression of pancreatic intraepithelial neoplasia (PanIN) to invasive carcinoma is a critical factor impacting the prognosis of patients with pancreatic tumors. However, the molecular mechanisms involved are not fully understood. We have reported that the process frequently involves loss of chromosome 8p, causing downregulation of DUSP4, thus conferring invasive ability on cancer cells. Here, we focus on ZNF395, whose expression was also found to be decreased by 8p loss and was predicted to be a growth suppressor gene. <b><i>Methods:</i></b> Pancreatic cancer cell lines inducibly expressing ZNF395 were established to assess the functional significance of ZNF395 in pancreatic carcinogenesis. Immunohistochemistry was also performed to analyze the expression levels of ZNF395 in pancreatic cancer tissues. <b><i>Results:</i></b> Induction of ZNF395 in pancreatic cancer cells resulted in marked activation of JNK and suppression of their proliferation through a delay in cell cycle progression. Immunohistochemistry revealed that ZNF395 was expressed ubiquitously in both normal pancreatic ducts and PanINs but was significantly reduced in invasive cancers, especially those showing poor differentiation. <b><i>Conclusion:</i></b> ZNF395 acts as a novel tumor suppressor gene. Its downregulation caused by 8p loss in intraepithelial cells accelerates their proliferation through dysregulation of the cell cycle, leading to progression to invasive cancer.
DOI: 10.6084/m9.figshare.14350544.v1
title: Supplementary Material for: Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential

description: <b><i>Background:</i></b> Progression of pancreatic intraepithelial neoplasia (PanIN) to invasive carcinoma is a critical factor impacting the prognosis of patients with pancreatic tumors. However, the molecular mechanisms involved are not fully understood. We have reported that the process frequently involves loss of chromosome 8p, causing downregulation of DUSP4, thus conferring invasive ability on cancer cells. Here, we focus on ZNF395, whose expression was also found to be decreased by 8p loss and was predicted to be a growth suppressor gene. <b><i>Methods:</i></b> Pancreatic cancer cell lines inducibly expressing ZNF395 were established to assess the functional significance of ZNF395 in pancreatic carcinogenesis. Immunohistochemistry was also performed to analyze the expression levels of ZNF395 in pancreatic cancer tissues. <b><i>Results:</i></b> Induction of ZNF395 in pancreatic cancer cells resulted in marked activation of JNK and suppression of their proliferation through a delay in cell cycle progression. Immunohistochemistry revealed that ZNF395 was expressed ubiquitously in both normal pancreatic ducts and PanINs but was significantly reduced in invasive cancers, especially those showing poor differentiation. <b><i>Conclusion:</i></b> ZNF395 acts as a novel tumor suppressor gene. Its downregulation caused by 8p loss in intraepithelial cells accelerates their proliferation through dysregulation of the cell cycle, leading to progression to invasive cancer.
DOI: 10.15479/at:ista:9291
title: Raw transport data for: Enhancement of proximity induced superconductivity in planar germanium

description: This .zip File contains the transport data for figures presented in the main text and supplementary material of "Enhancement of Proximity Induced Superconductivity in Planar Germanium" by K. Aggarwal, et. al. The measurements were done using Labber Software and the data is stored in the hdf5 file format. The files can be opened using either the Labber Log Browser (https://labber.org/overview/) or Labber Python API (http://labber.org/online-doc/api/LogFile.html).
DOI: 10.24378/exe.2683
title: Interhabitat Variability in Parrotfish Bioerosion Rates and Grazing Pressure on an Indian Ocean Reef Platform (dataset)

description: This is the dataset used for the Yarlett et al. (2020) article "Inter-Habitat Variability in Parrotfish Bioerosion Rates and Grazing Pressure on an Indian Ocean Reef Platform" published in Diversity."
description: Excel spreadsheets reporting raw data on parrotfish observations per time period and parrotfish residence times.
description: The article associated with this dataset is available in ORE at: http://hdl.handle.net/10871/125000
DOI: 10.14278/rodare.902
title: Data for: Entrance effects in a radial Hele-Shaw cell: numerical and experimental study

description: Hele-Shaw cells are a frequently used tool in various fields of chemical technology, and in environmental and biomedical engineering. The flow conditions near the inlet of a radial Hele-Shaw cell significantly affect the outcome of its technological applications. The present work combines Computational Fluid Dynamics (CFD) and micro-Particle Image Velocimetry (μPIV) to explain the entrance phenomena, i.e. flow detachment and vortex generation, in radial Hele-Shaw cells. The experiments show that the flow detachment is determined by the inlet flow Reynolds number, Re. Two-dimensional numerical simulations were employed to further investigate the role of the gap width, w to inlet diameter, D aspect ratio, w/D. The resulting flow regime map is divided by a transitional Re number, Ret, that depends on the aspect ratio. A further parametric study examining how Re and the aspect ratio affect the reattachment length yields an empirical correlation in power-law form. Finally, the impact of the inlet's geometrical features is briefly examined. The current work can be used as a design guide for future radial HS engineering applications.
DOI: 10.14278/rodare.901
title: Data for: Entrance effects in a radial Hele-Shaw cell: numerical and experimental study

description: Hele-Shaw cells are a frequently used tool in various fields of chemical technology, and in environmental and biomedical engineering. The flow conditions near the inlet of a radial Hele-Shaw cell significantly affect the outcome of its technological applications. The present work combines Computational Fluid Dynamics (CFD) and micro-Particle Image Velocimetry (μPIV) to explain the entrance phenomena, i.e. flow detachment and vortex generation, in radial Hele-Shaw cells. The experiments show that the flow detachment is determined by the inlet flow Reynolds number, Re. Two-dimensional numerical simulations were employed to further investigate the role of the gap width, w to inlet diameter, D aspect ratio, w/D. The resulting flow regime map is divided by a transitional Re number, Ret, that depends on the aspect ratio. A further parametric study examining how Re and the aspect ratio affect the reattachment length yields an empirical correlation in power-law form. Finally, the impact of the inlet's geometrical features is briefly examined. The current work can be used as a design guide for future radial HS engineering applications.
DOI: 10.5281/zenodo.4650362
title: Whole-genome analyses of 286 Magnaporthe oryzae genomes suggest that an independent introduction of a global pandemic lineage is at the origin of the Zambia wheat blast outbreak

description: The emergence of agricultural pests is a severe threat to global food security. The recent wheat blast outbreak in Bangladesh had devastating consequences for the country. More recently, a wheat blast outbreak in Zambia was assigned to the same tight group of genotypes originally introduced from South America into Bangladesh. Here, I analyzed publicly available whole-genome sequencing datasets shared by the OpenWheatBlast initiative. The aim is to contrast the Zambian outbreak strains with genome-wide differentiation of <em>Magnaporte oryzae </em>infecting different hosts. The genome-wide SNP analyses show that the Zambian outbreak strains are indeed highly similar to the strains responsible for the outbreak in Bangladesh as recently reported. The genomic data suggest that the Zambian outbreak may have originated from South America rather than a secondary introduction from the South Asian gene pool. The genome analyses confirm that wheat blast has emerged in recent years as a pandemic lineage across three continents. I provide the analyses as an open science contribution to the OpenWheatBlast initiative.
DOI: 10.5281/zenodo.4643632
title: POPC-SMALL-POSRES (3642 POPC @ 310K, 20 us)

description: Neat lipid membrane of 3642 POPC @ 310K, 20 us long. 25% of the upper leaflet lipids is weakly positions-restrained along the Z axis to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.5281/zenodo.4643631
title: POPC-SMALL-POSRES (3642 POPC @ 310K, 20 us)

description: Neat lipid membrane of 3642 POPC @ 310K, 20 us long. 25% of the upper leaflet lipids is weakly positions-restrained along the Z axis to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.5281/zenodo.4643554
title: POPC-LARGE-POSRES (6108 POPC @ 310K, 20 us)

description: Neat lipid membrane of 6108 POPC @ 310K, 20 us long. 25% of the upper leaflet lipids is weakly positions-restrained along the Z axis to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.5281/zenodo.4643553
title: POPC-LARGE-POSRES (6108 POPC @ 310K, 20 us)

description: Neat lipid membrane of 6108 POPC @ 310K, 20 us long. 25% of the upper leaflet lipids is weakly positions-restrained along the Z axis to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.5281/zenodo.4643615
title: POPC-LARGE-WALL (6108 POPC @ 310K, 20 us)

description: Neat lipid membrane of 6108 POPC @ 310K, 20 us long. WALL particles are used to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.5281/zenodo.4643634
title: POPC-SMALL-WALL (3642 POPC @ 310K, 20 us)

description: Neat lipid membrane of 3642 POPC @ 310K, 20 us long. WALL particles are used to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.5281/zenodo.4643633
title: POPC-SMALL-WALL (3642 POPC @ 310K, 20 us)

description: Neat lipid membrane of 3642 POPC @ 310K, 20 us long. WALL particles are used to suppress membrane undulations. Related flat simulations: POPC-LARGE-POSRES POPC-LARGE-WALL POPC-SMALL-POSRES POPC-SMALL-WALL Curved simulations: BUD / WAVE-LONG / WAVE-SHORT
DOI: 10.6084/m9.figshare.14350604
title: Jäck_et_al_Agronomy2021_data.xlsx

description: Data underlying the figures in the following paper:Jäck O, Ajal J, Weih M. Altered N Availability in Pea-Barley Sole- and Intercrops Changes Dominance of Two Nitrophilic Weed Species. <i>Agronomy </i><b>2021</b>.<br>
DOI: 10.5281/zenodo.4650351
title: Crossbow input data for ATC and FB aproach

description: These data refears to the load, generation and already allocated capacities (AAC) for five countries in the South Eastern Europe. Also these data are reported for a specific day in hourly basis as they are retrieved from Entso-E tranasparency platform. Simulation scenarios took place using this data for the ATC and FB aproach in SEE region in the frame of Crossbow project.
DOI: 10.5281/zenodo.4553219
title: The peak electron density of F2-layer (foF2) recorded by the oblique-incidence ionosonde network in North China from september 2009 to August 2011

description: The OIINDATA.zip contains 99 TXT files. Every single TXT file reports the peak electron density of F2-layer (foF2) recorded by one ionospheric observation point of the oblique-incidence ionosonde network from september 2009 to August 2011. The oblique-incidence ionosonde network station.txt file contains the information of every ionospheric observation point of the oblique-incidence ionosonde network in North China.
DOI: 10.5281/zenodo.4553218
title: The peak electron density of F2-layer (foF2) recorded by the oblique-incidence ionosonde network in North China from september 2009 to August 2011

description: The OIINDATA.zip contains 99 TXT files. Every single TXT file reports the peak electron density of F2-layer (foF2) recorded by one ionospheric observation point of the oblique-incidence ionosonde network from september 2009 to August 2011. The oblique-incidence ionosonde network station.txt file contains the information of every ionospheric observation point of the oblique-incidence ionosonde network in North China.
DOI: 10.15468/m8g59u
title: New arietellid copepods (Calanoida, Arietellidae) from anchialine caves in the Eastern Adriatic Sea

description: This dataset contains the digitized treatments in Plazi based on the original journal article Kršinić, Frano, Boxshall, Geoff A. (2021): New arietellid copepods (Calanoida, Arietellidae) from anchialine caves in the Eastern Adriatic Sea. Zootaxa 4951 (1): 107-129, DOI: https://doi.org/10.11646/zootaxa.4951.1.4
DOI: 10.6084/m9.figshare.12554789
title: Olfactory dysfunction data from patients with SARS-Cov-2 infection

description: NOTE: there is no peer-reviewed publication associated with this data record.<br><br>The dataset <b>Data File.xlsx</b>, is in .xlsx file format, and contains clinical data and data on olfactory dysfunction (25 variables in total), from 51 patients with the SARS-Cov-2 infection.The raw data are in the spreadsheet <b>Data-Table 1</b>.The spreadsheet <b>ReadMe File</b>, contains the meanings of all the abbreviated variables in spreadsheet Data-Table 1.<br><b>Patient consent</b>: The nature of this study and its procedures were explained to all subjects. All of them provided their written informed consent to participate.<br><b>Study aims and methodology: </b>The aim of this study was to quantify olfactory dysfunction by olfactometry in patients with laboratory confirmed SARS-Cov-2 infection. Patients from a particular Spanish health area with SARS-Cov-2 infection were recruited to study the loss of smell. Olfactometry was performed using the Sniffin Sticks test. The following clinical symptoms were studied: Ear Nose and Throat (ENT) symptoms related to infection, duration of sensorineural loss, subjective and objective score of loss of smell, and its temporal relationship with other systemic symptoms.For more details on the methodology, please read the related article.<br>
DOI: 10.6084/m9.figshare.12554789.v1
title: Olfactory dysfunction data from patients with SARS-Cov-2 infection

description: NOTE: there is no peer-reviewed publication associated with this data record.<br><br>The dataset <b>Data File.xlsx</b>, is in .xlsx file format, and contains clinical data and data on olfactory dysfunction (25 variables in total), from 51 patients with the SARS-Cov-2 infection.The raw data are in the spreadsheet <b>Data-Table 1</b>.The spreadsheet <b>ReadMe File</b>, contains the meanings of all the abbreviated variables in spreadsheet Data-Table 1.<br><b>Patient consent</b>: The nature of this study and its procedures were explained to all subjects. All of them provided their written informed consent to participate.<br><b>Study aims and methodology: </b>The aim of this study was to quantify olfactory dysfunction by olfactometry in patients with laboratory confirmed SARS-Cov-2 infection. Patients from a particular Spanish health area with SARS-Cov-2 infection were recruited to study the loss of smell. Olfactometry was performed using the Sniffin Sticks test. The following clinical symptoms were studied: Ear Nose and Throat (ENT) symptoms related to infection, duration of sensorineural loss, subjective and objective score of loss of smell, and its temporal relationship with other systemic symptoms.For more details on the methodology, please read the related article.<br>
DOI: 10.5523/bris.2ld1on1vrlzba2o05jd5jhdhd0
title: CauchySAR_v1
title: Solving SAR Imagery Inverse Problems via Cauchy Proximal Splitting

description: This software includes MATLAB source code for solving SAR imaging inverse problems using the Cauchy proximal splitting (CPS) algorithm. CPS is a method for the optimization of a cost function that includes a non-convex Cauchy-based penalty. The convergence of the overall cost function optimization is ensured through careful selection of model parameters within a forward-backward (FB) algorithm. The package includes solutions to three standard SAR imaging inverse problems, i.e. super-resolution, image formation, and despeckling, as well as ship wake detection for maritime applications.