cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7128380
title: Results from a survey of personality traits and competencies among middle managers

description: This article presents data from a survey of the personalities of 113 middle managers as well as managerial competencies such as: focus on results, social skills, openness to change, problem solving, and employee development.<br>
DOI: 10.6084/m9.figshare.7128380.v1
title: Results from a survey of personality traits and competencies among middle managers

description: This article presents data from a survey of the personalities of 113 middle managers as well as managerial competencies such as: focus on results, social skills, openness to change, problem solving, and employee development.<br>
DOI: 10.25373/ctsnet.7128347
title: Management of Complex Paraesophageal Hernias

description: Paraesophageal hernias are complex and challenging when they occur with acute symptoms, in malnourished patients, or when there is gastric ischemia. Treatment should be individualized based on each patient’s clinical characteristics. Medical treatment is often offered to most patients without chronic symptoms. In elective patients with good preoperative performance, surgical repair should be performed to resolve potential gastric or esophageal problems. In emergent cases, initial resuscitation and decompression may allow the patient to stabilize, especially when they can be endoscopically decompressed. This may allow patients additional time to recover before a surgical repair is performed prior to discharge. Surgical repair is often the best answer, but patients presenting for reoperation should only undergo reoperation if they have severe symptoms. The viability of the stomach and imaging, especially 3D imaging, can greatly influence what type of repair is needed, the repair timing, and whether or not adjunctive surgeries, such as a feeding tube placement, are required. Tenets of a good repair include: no mesh against the esophagus, crural closure, fundoplication in good candidates, gastropexy, and cruropexy. The video above reviews each step of a complex patient management algorithm (shown below) that guides the surgeon and team through the difficult decisions of managing paraesophageal hernias.Learn more and find a list of additional resources at: https://www.ctsnet.org/article/management-complex-paraesophageal-hernias
DOI: 10.25373/ctsnet.7128347.v2
title: Management of Complex Paraesophageal Hernias

description: Paraesophageal hernias are complex and challenging when they occur with acute symptoms, in malnourished patients, or when there is gastric ischemia. Treatment should be individualized based on each patient’s clinical characteristics. Medical treatment is often offered to most patients without chronic symptoms. In elective patients with good preoperative performance, surgical repair should be performed to resolve potential gastric or esophageal problems. In emergent cases, initial resuscitation and decompression may allow the patient to stabilize, especially when they can be endoscopically decompressed. This may allow patients additional time to recover before a surgical repair is performed prior to discharge. Surgical repair is often the best answer, but patients presenting for reoperation should only undergo reoperation if they have severe symptoms. The viability of the stomach and imaging, especially 3D imaging, can greatly influence what type of repair is needed, the repair timing, and whether or not adjunctive surgeries, such as a feeding tube placement, are required. Tenets of a good repair include: no mesh against the esophagus, crural closure, fundoplication in good candidates, gastropexy, and cruropexy. The video above reviews each step of a complex patient management algorithm (shown below) that guides the surgeon and team through the difficult decisions of managing paraesophageal hernias.Learn more and find a list of additional resources at: https://www.ctsnet.org/article/management-complex-paraesophageal-hernias
DOI: 10.25373/ctsnet.7128347.v1
title: Management of Complex Paraesophageal Hernias

description: Paraesophageal hernias are complex and challenging when they occur with acute symptoms, in malnourished patients, or when there is gastric ischemia. Treatment should be individualized based on each patient’s clinical characteristics. Medical treatment is often offered to most patients without chronic symptoms. In elective patients with good preoperative performance, surgical repair should be performed to resolve potential gastric or esophageal problems. In emergent cases, initial resuscitation and decompression may allow the patient to stabilize, especially when they can be endoscopically decompressed. This may allow patients additional time to recover before a surgical repair is performed prior to discharge. Surgical repair is often the best answer, but patients presenting for reoperation should only undergo reoperation if they have severe symptoms. The viability of the stomach and imaging, especially 3D imaging, can greatly influence what type of repair is needed, the repair timing, and whether or not adjunctive surgeries, such as a feeding tube placement, are required. Tenets of a good repair include: no mesh against the esophagus, crural closure, fundoplication in good candidates, gastropexy, and cruropexy. The video above reviews each step of a complex patient management algorithm (shown below) that guides the surgeon and team through the difficult decisions of managing paraesophageal hernias.Learn more and find a list of additional resources at: https://www.ctsnet.org/article/management-complex-paraesophageal-hernias
DOI: 10.17608/k6.auckland.7128221
title: SEM input for CNI-PPC to SDQ

description: This is the AMOS input file for measuring the relationship of the parent responses to the Connectedness to Nature Index factors upon the parent responses to the Strengths and Difficulties Questionnaire (SDQ).
DOI: 10.6084/m9.figshare.7128209
title: Multiple Puf proteins regulate the stability of ribosome biogenesis transcripts

description: Cells must make careful use of the resources available to them. A key area of cellular regulation involves the biogenesis of ribosomes. Transcriptional regulation of ribosome biogenesis factor genes through alterations in histone acetylation has been well studied. This work identifies a post-transcriptional mechanism of ribosome biogenesis regulation by Puf protein control of mRNA stability. Puf proteins are eukaryotic mRNA binding proteins that play regulatory roles in mRNA degradation and translation via association with specific conserved elements in the 3ʹ untranslated region (UTR) of target mRNAs and with degradation and translation factors. We demonstrate that several ribosome biogenesis factor mRNAs in <i>Saccharomyces cerevisiae</i> containing a canonical Puf4p element in their 3ʹ UTRs are destabilized by Puf2p, Puf4, and Puf5p, yet stabilized by Puf1p and Puf3p. In the absence of all Puf proteins, these ribosome biogenesis mRNAs are destabilized by a secondary mechanism involving the same 3ʹ UTR element. Unlike other targets of Puf4p regulation, the decay of these transcripts is not altered by carbon source. Overexpression of Puf4p results in delayed ribosomal RNA processing and altered ribosomal subunit trafficking. These results represent a novel role for Puf proteins in yeast as regulators of ribosome biogenesis transcript stability.
DOI: 10.6084/m9.figshare.7128209.v1
title: Multiple Puf proteins regulate the stability of ribosome biogenesis transcripts

description: Cells must make careful use of the resources available to them. A key area of cellular regulation involves the biogenesis of ribosomes. Transcriptional regulation of ribosome biogenesis factor genes through alterations in histone acetylation has been well studied. This work identifies a post-transcriptional mechanism of ribosome biogenesis regulation by Puf protein control of mRNA stability. Puf proteins are eukaryotic mRNA binding proteins that play regulatory roles in mRNA degradation and translation via association with specific conserved elements in the 3ʹ untranslated region (UTR) of target mRNAs and with degradation and translation factors. We demonstrate that several ribosome biogenesis factor mRNAs in <i>Saccharomyces cerevisiae</i> containing a canonical Puf4p element in their 3ʹ UTRs are destabilized by Puf2p, Puf4, and Puf5p, yet stabilized by Puf1p and Puf3p. In the absence of all Puf proteins, these ribosome biogenesis mRNAs are destabilized by a secondary mechanism involving the same 3ʹ UTR element. Unlike other targets of Puf4p regulation, the decay of these transcripts is not altered by carbon source. Overexpression of Puf4p results in delayed ribosomal RNA processing and altered ribosomal subunit trafficking. These results represent a novel role for Puf proteins in yeast as regulators of ribosome biogenesis transcript stability.
DOI: 10.6084/m9.figshare.7128206
title: Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis

description: <b>Objectives:</b> To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. <b>Methods:</b> PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach. <b>Results:</b> Nine randomized controlled trials (RCTs) and two non-RCTs were adopted for remission induction therapy, three RCTs and two non-RCTs for plasma exchange, and five RCTs and one non-RCT for remission maintenance therapy. A significant difference was found in efficacy and safety for the following comparisons. In the non-RCT adopted for remission induction therapy, glucocorticoid (GC) + cyclophosphamide (CY) was significantly superior to GC monotherapy regarding remission. GC + intravenous CY for remission induction therapy was superior to GC + oral CY regarding death at one year, serious adverse events, and serious infection. Concomitant use of plasma exchange for remission induction therapy of AAV with severe renal dysfunction reduced risk of end-stage renal disease versus non-users at month 3. <b>Conclusion:</b> This SR provided necessary evidence for developing CPG for the management of ANCA-associated vasculitis.
DOI: 10.6084/m9.figshare.7128206.v1
title: Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis

description: <b>Objectives:</b> To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. <b>Methods:</b> PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach. <b>Results:</b> Nine randomized controlled trials (RCTs) and two non-RCTs were adopted for remission induction therapy, three RCTs and two non-RCTs for plasma exchange, and five RCTs and one non-RCT for remission maintenance therapy. A significant difference was found in efficacy and safety for the following comparisons. In the non-RCT adopted for remission induction therapy, glucocorticoid (GC) + cyclophosphamide (CY) was significantly superior to GC monotherapy regarding remission. GC + intravenous CY for remission induction therapy was superior to GC + oral CY regarding death at one year, serious adverse events, and serious infection. Concomitant use of plasma exchange for remission induction therapy of AAV with severe renal dysfunction reduced risk of end-stage renal disease versus non-users at month 3. <b>Conclusion:</b> This SR provided necessary evidence for developing CPG for the management of ANCA-associated vasculitis.
DOI: 10.17608/k6.auckland.7128197
title: Connectedness to Nature Index-Parents of PreSchool Children

description: This data set in SPSS format was obtained by Dr Tanja Sobko from parent perceptions survey of pre-school children's connectedness to nature and their strengths and difficulties. The data consist of 25 items from the SDQ inventory and 20 items of the Connectedness to Nature Index for Parents of Preschool Children. Analyses were conducted by Prof Gavin Brown, the University of Auckland.
DOI: 10.6084/m9.figshare.7128152
title: Rawvalues of genetic variances for Petrizzelli et al. 2018

description: Rawdata of the genetic effects variances estimated in https://doi.org/10.1101/362418
DOI: 10.6084/m9.figshare.7128152.v2
title: Rawvalues of genetic variances for Petrizzelli et al. 2018

description: Rawdata of the genetic effects variances estimated in https://doi.org/10.1101/362418
DOI: 10.6084/m9.figshare.7128152.v1
title: Rawvalues of genetic variances

description: Rawdata of the genetic effects variances estimated in https://doi.org/10.1101/362418
DOI: 10.6084/m9.figshare.7127867
title: Python scripts

description: Python codes to read the table with the simulated BNS mergers<br>
DOI: 10.6084/m9.figshare.7127795
title: data_preprocessed

description: This is the Wakeman and Henson data preprocessed using the Oostenveld script.<br>
DOI: 10.6084/m9.figshare.7127867.v1
title: Python scripts

description: Python codes to read the table with the simulated BNS mergers<br>
DOI: 10.6084/m9.figshare.7127726
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127723
title: Software makes science better, but is it research? DotAstonomy X Presentation

description: Invited Presentation at .Astronomy X conference
DOI: 10.6084/m9.figshare.7127726.v1
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127693
title: Abundance-weighted community composition, environmental drivers, and phylogeny of acid seep springs following stream down-cutting and invasion of Microstegium vimineum.

description: All materials related to Barfknecht and Gibson 2018
DOI: 10.6084/m9.figshare.7127726.v2
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127693.v1
title: Abundance-weighted community composition, environmental drivers, and phylogeny of acid seep springs following stream down-cutting and invasion of Microstegium vimineum.

description: All materials related to Barfknecht and Gibson 2018
DOI: 10.6084/m9.figshare.7127555
title: Raw data of the specimens (2)

description: Raw data of the specimens in Insect Collection of Central South University of Forestry and Technology.
DOI: 10.6084/m9.figshare.7127555.v1
title: Raw data of the specimens (2)

description: Raw data of the specimens in Insect Collection of Central South University of Forestry and Technology.
DOI: 10.6084/m9.figshare.7127537
title: 13 CDS and 2 rRNA alignment file

description: The alignment file of 13 CDS and 2 rRNA.
DOI: 10.6084/m9.figshare.7127537.v1
title: 13 CDS and 2 rRNA alignment file

description: The alignment file of 13 CDS and 2 rRNA.
DOI: 10.6084/m9.figshare.7127726.v5
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127537.v2
title: 13 CDS and 2 rRNA alignment file

description: The alignment file of 13 CDS and 2 rRNA.
DOI: 10.6084/m9.figshare.7127537.v3
title: 13 CDS and 2 rRNA alignment file

description: The alignment file of 13 CDS and 2 rRNA.
DOI: 10.6084/m9.figshare.7127726.v7
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127726.v8
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127726.v12
title: PPTC RNAseq and Genomic Alterations

description: Data deposited here have origins through the National Cancer Institute Pediatric Preclinical Testing Consortion (NCI PPTC) and Alex's Lemonade Stand.<br>The RNAseq data is an FPKM matrix of 250 samples measured across 51,968 genes.<br>The alterations matrix consist of deleterious DNA mutations, DNA copy number alterations, and fusions of varying functional confidence.<br>Gene expression classifiers are applied to the gene expression matrix and the results are interpreted in https://github.com/marislab/pdx-classification
DOI: 10.6084/m9.figshare.7127384
title: DataExporteefexp2

description: Postural Sway
DOI: 10.6084/m9.figshare.7127384.v1
title: DataExporteefexp2

description: Postural Sway
DOI: 10.6084/m9.figshare.7127372
title: Simulation code: nonspatial model from A spatio-temporal model reveals self-limiting Fc<i>ɛ</i>RI cross-linking by multivalent antigens

description: Aggregation of cell surface receptor proteins by multivalent antigens is an essential early step for immune cell signalling. A number of experimental and modelling studies in the past have investigated multivalent ligand-mediated aggregation of IgE receptors (Fc<i>ɛ</i>RI) in the plasma membrane of mast cells. However, understanding of the mechanisms of Fc<i>ɛ</i>RI aggregation remains incomplete. Experimental reports indicate that Fc<i>ɛ</i>RI forms relatively small and finite-sized clusters when stimulated by a multivalent ligand. By contrast, modelling studies have shown that receptor cross-linking by a trivalent ligand may lead to the formation of large receptor superaggregates that may potentially give rise to hyperactive cellular responses. In this work, we have developed a Brownian dynamics-based spatio-temporal model to analyse Fc<i>ɛ</i>RI aggregation by a trivalent antigen. Unlike the existing models, which implemented non-spatial simulation approaches, our model explicitly accounts for the coarse-grained site-specific features of the multivalent species (molecules and complexes). The model incorporates membrane diffusion, steric collisions and sub-nanometre-scale site-specific interaction of the time-evolving species of arbitrary structures. Using the model, we investigated temporal evolution of the species and their diffusivities. Consistent with a recent experimental report, our model predicted sharp decay in species mobility in the plasma membrane in response receptor cross-linking by a multivalent antigen. We show that, due to such decay in the species mobility, post-stimulation receptor aggregation may become self-limiting. Our analysis reveals a potential regulatory mechanism suppressing hyperactivation of immune cells in response to multivalent antigens.
DOI: 10.6084/m9.figshare.7127372.v1
title: Simulation code: nonspatial model from A spatio-temporal model reveals self-limiting Fc<i>ɛ</i>RI cross-linking by multivalent antigens

description: Aggregation of cell surface receptor proteins by multivalent antigens is an essential early step for immune cell signalling. A number of experimental and modelling studies in the past have investigated multivalent ligand-mediated aggregation of IgE receptors (Fc<i>ɛ</i>RI) in the plasma membrane of mast cells. However, understanding of the mechanisms of Fc<i>ɛ</i>RI aggregation remains incomplete. Experimental reports indicate that Fc<i>ɛ</i>RI forms relatively small and finite-sized clusters when stimulated by a multivalent ligand. By contrast, modelling studies have shown that receptor cross-linking by a trivalent ligand may lead to the formation of large receptor superaggregates that may potentially give rise to hyperactive cellular responses. In this work, we have developed a Brownian dynamics-based spatio-temporal model to analyse Fc<i>ɛ</i>RI aggregation by a trivalent antigen. Unlike the existing models, which implemented non-spatial simulation approaches, our model explicitly accounts for the coarse-grained site-specific features of the multivalent species (molecules and complexes). The model incorporates membrane diffusion, steric collisions and sub-nanometre-scale site-specific interaction of the time-evolving species of arbitrary structures. Using the model, we investigated temporal evolution of the species and their diffusivities. Consistent with a recent experimental report, our model predicted sharp decay in species mobility in the plasma membrane in response receptor cross-linking by a multivalent antigen. We show that, due to such decay in the species mobility, post-stimulation receptor aggregation may become self-limiting. Our analysis reveals a potential regulatory mechanism suppressing hyperactivation of immune cells in response to multivalent antigens.