cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6080660
title: Supplementary Material for: Perioperative Changes and Progress in Photoselective Vaporization of the Prostate with GreenLight XPS 180 W System: A Single Center Experience

description: <b><i>Purpose:</i></b> The study aimed to evaluate progression of GreenLight-XPS 180 W photoselective vaporization of the prostate (GL-XPS) with respect to effectiveness, efficacy, and safety over time at a tertiary referral high volume center. <b><i>Methods:</i></b> The retrospective study included 375 men who underwent GL-XPS for symptomatic benign prostate obstruction (BPO) between June 2010 and February 2015. Primary outcome measurements were operation time (OT; min) and effective laser time (LT; min of OT) analyzed with regard to prostatic volume (PV; mL) (group 1 &lt;40 mL up to 4 &gt;80 mL in 20 mL steps) and the year of surgery (2010–2015). <b><i>Results:</i></b> The median age was 72 years (range 64–79), the median PV was 58 mL (range 33–98) and the median PV increased from 42 mL in 2012 to 80 mL in 2015. The OT and LT clearly correlated with the PV, being doubled for glands of median 95 mL compared to median 30 mL while the applied laser energy per LT likewise steadily increased. Overall, both OT and LT could be significantly reduced each year by 37% (OT; <i>p</i> &lt; 0.05) and 36% (LT; <i>p</i> &lt; 0.05) within 5 years. The hospital stay (days) and catheterization time (days) remained constant, without any changes over time. The overall complication rate (Clavien-Dindo &gt;2) ranged from 36 to 15% between 2010 and 2015. The pre (median 22 + 4) and postoperative International Prostate Symptom Score-Quality of Life (median 5 + 1) showed a sufficient reduction in symptomatic BPO. <b><i>Conclusion:</i></b> GL-XPS is a safe and effective surgical method for symptomatic BPO. Our single center experience showed a significant improvement of both OT and effective LT within 5 years whilst maintaining stable low complication rate and high patient satisfaction.
DOI: 10.6084/m9.figshare.6080660.v1
title: Supplementary Material for: Perioperative Changes and Progress in Photoselective Vaporization of the Prostate with GreenLight XPS 180 W System: A Single Center Experience

description: <b><i>Purpose:</i></b> The study aimed to evaluate progression of GreenLight-XPS 180 W photoselective vaporization of the prostate (GL-XPS) with respect to effectiveness, efficacy, and safety over time at a tertiary referral high volume center. <b><i>Methods:</i></b> The retrospective study included 375 men who underwent GL-XPS for symptomatic benign prostate obstruction (BPO) between June 2010 and February 2015. Primary outcome measurements were operation time (OT; min) and effective laser time (LT; min of OT) analyzed with regard to prostatic volume (PV; mL) (group 1 &lt;40 mL up to 4 &gt;80 mL in 20 mL steps) and the year of surgery (2010–2015). <b><i>Results:</i></b> The median age was 72 years (range 64–79), the median PV was 58 mL (range 33–98) and the median PV increased from 42 mL in 2012 to 80 mL in 2015. The OT and LT clearly correlated with the PV, being doubled for glands of median 95 mL compared to median 30 mL while the applied laser energy per LT likewise steadily increased. Overall, both OT and LT could be significantly reduced each year by 37% (OT; <i>p</i> &lt; 0.05) and 36% (LT; <i>p</i> &lt; 0.05) within 5 years. The hospital stay (days) and catheterization time (days) remained constant, without any changes over time. The overall complication rate (Clavien-Dindo &gt;2) ranged from 36 to 15% between 2010 and 2015. The pre (median 22 + 4) and postoperative International Prostate Symptom Score-Quality of Life (median 5 + 1) showed a sufficient reduction in symptomatic BPO. <b><i>Conclusion:</i></b> GL-XPS is a safe and effective surgical method for symptomatic BPO. Our single center experience showed a significant improvement of both OT and effective LT within 5 years whilst maintaining stable low complication rate and high patient satisfaction.
DOI: 10.6084/m9.figshare.6080549
title: date.txt

description: Frequency difference of Rayleigh backscattering<br>
DOI: 10.6084/m9.figshare.6080549.v1
title: date.txt

description: Frequency difference of Rayleigh backscattering<br>
DOI: 10.6084/m9.figshare.6080540
title: Supplementary Material for: Predictive Value of Four-Dimensional Strain Echocardiography for Adverse Cardiovascular Outcomes in ST-Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention

description: <b><i>Objectives:</i></b> To investigate the predictive value of four-dimensional (4D) strain echocardiography for major adverse cardiovascular events (MACE) in ST-elevation acute myocardial infarction (STEMI) patients. <b><i>Methods:</i></b> Consecutive STEMI patients who underwent successful primary coronary interven tion (PCI) were enrolled and followed, with 2D and 4D strain echocardiography performed within 1 week after PCI. <b><i>Results:</i></b> Twenty-six first MACE were recorded in 81 patients who finished a ∼3.0 year follow-up. Compared with those without MACE, subjects with MACE were more likely to have anterior MI (73.08 vs. 38.18%, <i>p</i> = 0.003), significantly decreased 2D left ventricular ejection fraction (2DLVEF) and 4DLVEF (all <i>p</i> &lt; 0.05), as well as an overtly compromised 4D strain parameters. The prediction models incorporating infarct location with either 2DLVEF or 4D strain parameters were then developed. Model comparisons revealed that the global area strain (GAS)-based model had the highest discriminative capacity (c statistics = 0.774) and was well calibrated for MACE. Additionally, the clinical utility of the GAS-based prediction model was verified by decision curve analysis showing a consistent positive and larger net benefit compared to the 2DLVEF-based model. <b><i>Conclusions:</i></b> Our data support a superiority of 4D strain echocardiography over conventional 2D echocardiography, especially GAS, for risk stratification in STEMI patients after successful primary PCI.
DOI: 10.6084/m9.figshare.6080540.v1
title: Supplementary Material for: Predictive Value of Four-Dimensional Strain Echocardiography for Adverse Cardiovascular Outcomes in ST-Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention

description: <b><i>Objectives:</i></b> To investigate the predictive value of four-dimensional (4D) strain echocardiography for major adverse cardiovascular events (MACE) in ST-elevation acute myocardial infarction (STEMI) patients. <b><i>Methods:</i></b> Consecutive STEMI patients who underwent successful primary coronary interven tion (PCI) were enrolled and followed, with 2D and 4D strain echocardiography performed within 1 week after PCI. <b><i>Results:</i></b> Twenty-six first MACE were recorded in 81 patients who finished a ∼3.0 year follow-up. Compared with those without MACE, subjects with MACE were more likely to have anterior MI (73.08 vs. 38.18%, <i>p</i> = 0.003), significantly decreased 2D left ventricular ejection fraction (2DLVEF) and 4DLVEF (all <i>p</i> &lt; 0.05), as well as an overtly compromised 4D strain parameters. The prediction models incorporating infarct location with either 2DLVEF or 4D strain parameters were then developed. Model comparisons revealed that the global area strain (GAS)-based model had the highest discriminative capacity (c statistics = 0.774) and was well calibrated for MACE. Additionally, the clinical utility of the GAS-based prediction model was verified by decision curve analysis showing a consistent positive and larger net benefit compared to the 2DLVEF-based model. <b><i>Conclusions:</i></b> Our data support a superiority of 4D strain echocardiography over conventional 2D echocardiography, especially GAS, for risk stratification in STEMI patients after successful primary PCI.
DOI: 10.6084/m9.figshare.6080495
title: Conceptual and statistical problems with the use of the Shannon-Weiner entropy index in bioacoustic analyses

description: Information theory and its indices were developed for human communication to predict the amount of information transferred in a message. One such index, the Shannon-Weiner index (SWI), has often been used to analyse information from other fields in which its application may not be appropriate. In ecoacoustics, SWI is used to compare acoustic diversity (i.e. a measure derived by integrating the richness and abundance of animal sounds) between locations. In animal communication, SWI is used to quantify repertoire complexity (i.e. a measure derived by integrating the number and abundance of sound types produced by individuals or species) as an approach to understanding signal evolution. We discuss problems associated with using the SWI in ecoacoustics and animal communication. Specifically, we discuss conceptual and statistical problems associated with the SWI and then illustrate these problems using hypothetical data. In ecoacoustics, the SWI’s assumptions of random variables and independent samples are often violated. In animal communication, the SWI fails to distinguish among repertoires in which the number of sound types and the abundance of each sound type differ. We also show that other methods do capture these differences. We conclude that the SWI does not adequately represent acoustic diversity or repertoire complexity due to the multiple conceptual and statistical issues associated with its use. We recommend other analytical methods to more fully describe these biological systems, including goodness of fit, Morisita similarity index and Markov chain analysis. These methods provide more information for future comparisons and permit researchers to test hypotheses more directly.
DOI: 10.6084/m9.figshare.6080495.v1
title: Conceptual and statistical problems with the use of the Shannon-Weiner entropy index in bioacoustic analyses

description: Information theory and its indices were developed for human communication to predict the amount of information transferred in a message. One such index, the Shannon-Weiner index (SWI), has often been used to analyse information from other fields in which its application may not be appropriate. In ecoacoustics, SWI is used to compare acoustic diversity (i.e. a measure derived by integrating the richness and abundance of animal sounds) between locations. In animal communication, SWI is used to quantify repertoire complexity (i.e. a measure derived by integrating the number and abundance of sound types produced by individuals or species) as an approach to understanding signal evolution. We discuss problems associated with using the SWI in ecoacoustics and animal communication. Specifically, we discuss conceptual and statistical problems associated with the SWI and then illustrate these problems using hypothetical data. In ecoacoustics, the SWI’s assumptions of random variables and independent samples are often violated. In animal communication, the SWI fails to distinguish among repertoires in which the number of sound types and the abundance of each sound type differ. We also show that other methods do capture these differences. We conclude that the SWI does not adequately represent acoustic diversity or repertoire complexity due to the multiple conceptual and statistical issues associated with its use. We recommend other analytical methods to more fully describe these biological systems, including goodness of fit, Morisita similarity index and Markov chain analysis. These methods provide more information for future comparisons and permit researchers to test hypotheses more directly.
DOI: 10.6084/m9.figshare.6080402
title: Genome lengths of common viruses pathogenic to humans

description: We have used viral sequences available in Genbank (The National Center for Biotechnology Information, NCBI) to assimilate a table of viruses that may be isolated from human hosts (most of these are pathogens, but some may occur as bystanders in metagenomic datasets).For each virus, we have listed the typical genome length (in nucleotides) to allow comparison between individual agents and between different types of virus. For the majority of viruses, there is also a reference sequence listed by Genbank, for which we have provided a link / accession number. <br>Data sourced from https://www.ncbi.nlm.nih.gov/genomes/GenomesGroup.cgi?taxid=10239&host=human
DOI: 10.6084/m9.figshare.6080402.v1
title: Genome lengths of common viruses pathogenic to humans

description: We have used viral sequences available in Genbank (The National Center for Biotechnology Information, NCBI) to assimilate a table of viruses that may be isolated from human hosts (most of these are pathogens, but some may occur as bystanders in metagenomic datasets).For each virus, we have listed the typical genome length (in nucleotides) to allow comparison between individual agents and between different types of virus. For the majority of viruses, there is also a reference sequence listed by Genbank, for which we have provided a link / accession number. <br>Data sourced from https://www.ncbi.nlm.nih.gov/genomes/GenomesGroup.cgi?taxid=10239&host=human
DOI: 10.6084/m9.figshare.6080396
title: data_used_for_article.zip

description: <i><b>Trust or robustness? An ecological approach to the study of auction and bilateral markets. <br></b></i>
DOI: 10.6084/m9.figshare.6080333
title: Underlying data for a 100% organic conversion study

description: Underlying data for ‘Greenhouse gas impacts of converting all farming in England and Wales to organic methods’ by L.G. Smith et al. (2019). We apply a bespoke model to estimate levels of production from agriculture in England and Wales under organic management. Outputs are compared to the real-world distribution of conventional production in 2010, derived from a range of industry sources. The environmental impacts of the organic production scenario are assessed through an application of the Cranfield Agri-LCA models together with country-specific estimates of GHG emissions from Land Use Change (LUC) and carbon sequestration estimates <br><br>
DOI: 10.6084/m9.figshare.6080333.v1
title: Underlying data for a 100% organic conversion study

description: Underlying data for ‘Greenhouse gas impacts of converting all farming in England and Wales to organic methods’ by L.G. Smith et al. (2019). We apply a bespoke model to estimate levels of production from agriculture in England and Wales under organic management. Outputs are compared to the real-world distribution of conventional production in 2010, derived from a range of industry sources. The environmental impacts of the organic production scenario are assessed through an application of the Cranfield Agri-LCA models together with country-specific estimates of GHG emissions from Land Use Change (LUC) and carbon sequestration estimates <br><br>
DOI: 10.6084/m9.figshare.6080234
title: Raw data of the experiments from Categorizing experience-based foraging plasticity in mites: age dependency, primacy effects and memory persistence

description: Raw data of the experiments
DOI: 10.6084/m9.figshare.6079190
title: Salishicetus Final Matrix from <i>Salishicetus meadi</i>, a new aetiocetid from the late Oligocene of Washington State and implications for feeding transitions in early mysticete evolution

description: Nexus file of matrix used for phylogenetic analysis
DOI: 10.6084/m9.figshare.6079190.v1
title: Salishicetus Final Matrix from <i>Salishicetus meadi</i>, a new aetiocetid from the late Oligocene of Washington State and implications for feeding transitions in early mysticete evolution

description: Nexus file of matrix used for phylogenetic analysis
DOI: 10.6084/m9.figshare.6078758
title: data_RSF.RData

description: Data used for RSF analyses and to further determine the individual specialization in resource selection (ISRS), in Courbin N, Besnard A, Péron C, Saraux C, Fort J, Perret S, Tornos J, Gremillet D Data from: Short-term prey field lability constrains individual specialization in resource selection and foraging site fidelity in a marine predator. Ecology Letters, DOI:10.1111/ele.12970.<br>
DOI: 10.6084/m9.figshare.6078758.v1
title: data_RSF.RData

description: Data used for RSF analyses and to further determine the individual specialization in resource selection (ISRS), in Courbin N, Besnard A, Péron C, Saraux C, Fort J, Perret S, Tornos J, Gremillet D Data from: Short-term prey field lability constrains individual specialization in resource selection and foraging site fidelity in a marine predator. Ecology Letters, DOI:10.1111/ele.12970.<br>
DOI: 10.6084/m9.figshare.6078734
title: DATA RAW DESCRIPTION.xlsx

description: These 2 files contained the data used to run the analyses of the manuscript entitled 'A global analysis of terrestrial plant litter dynamics in non-perennial waterways". <br><br>One file contains the raw data, the other the description of each variable. For more information, see the full manuscript.<br><b></b><br><br>
DOI: 10.6084/m9.figshare.6078734.v1
title: DATA RAW DESCRIPTION.xlsx

description: These 2 files contained the data used to run the analyses of the manuscript entitled 'A global analysis of terrestrial plant litter dynamics in non-perennial waterways". <br><br>One file contains the raw data, the other the description of each variable. For more information, see the full manuscript.<br><b></b><br><br>
DOI: 10.6084/m9.figshare.6078734.v3
title: DATA RAW DESCRIPTION.xlsx

description: These 2 files contained the data used to run the analyses of the manuscript entitled 'A global analysis of terrestrial plant litter dynamics in non-perennial waterways". <br><br>One file contains the raw data, the other the description of each variable. For more information, see the full manuscript.<br><b></b><br><br>
DOI: 10.6084/m9.figshare.6078695
title: Supplementary Material for: Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Acetaminophen is the most commonly used antipyretic in children. However, there are limited data assessing hypersensitivity reactions related to acetaminophen usage. <b><i>Objectives:</i></b> To conduct a systematic review to characterize reported reactions to acetaminophen in adults and children, and perform a meta-analysis to assess the prevalence of acetaminophen hypersensitivity in children with a suspected acetaminophen allergy. <b><i>Methods:</i></b> We performed a systematic review of studies reporting hypersensitivity reactions to acetaminophen by searching 2 electronic databases. From the selected studies, we included those assessing the prevalence of acetaminophen hypersensitivity by performing oral challenge in our meta-analysis. <b><i>Results:</i></b> Eighty-five studies were included in the systematic review, assessing a total of 1,030 participants. Immediate (within 1 h of exposure) hypersensitivity reactions were reported in &gt; 25% of the articles, while cutaneous nonimmediate reactions were similarly reported in about 25% of the articles. The remaining articles reported Steven-Johnson syndrome/toxic epidermal necrolysis, fixed drug eruptions, and cross-intolerance reactions. Five pediatric studies were included in our meta-analysis. The prevalence of acetaminophen hypersensitivity reaction among children undergoing oral challenge was 10.1% (95% confidence interval 4.5–15.5). <b><i>Conclusion:</i></b> Future studies assessing the risk of immediate and nonimmediate hypersensitivity reactions to acetaminophen and elucidating the mechanism of acetaminophen hypersensitivity reactions are required.
DOI: 10.6084/m9.figshare.6078695.v1
title: Supplementary Material for: Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Acetaminophen is the most commonly used antipyretic in children. However, there are limited data assessing hypersensitivity reactions related to acetaminophen usage. <b><i>Objectives:</i></b> To conduct a systematic review to characterize reported reactions to acetaminophen in adults and children, and perform a meta-analysis to assess the prevalence of acetaminophen hypersensitivity in children with a suspected acetaminophen allergy. <b><i>Methods:</i></b> We performed a systematic review of studies reporting hypersensitivity reactions to acetaminophen by searching 2 electronic databases. From the selected studies, we included those assessing the prevalence of acetaminophen hypersensitivity by performing oral challenge in our meta-analysis. <b><i>Results:</i></b> Eighty-five studies were included in the systematic review, assessing a total of 1,030 participants. Immediate (within 1 h of exposure) hypersensitivity reactions were reported in &gt; 25% of the articles, while cutaneous nonimmediate reactions were similarly reported in about 25% of the articles. The remaining articles reported Steven-Johnson syndrome/toxic epidermal necrolysis, fixed drug eruptions, and cross-intolerance reactions. Five pediatric studies were included in our meta-analysis. The prevalence of acetaminophen hypersensitivity reaction among children undergoing oral challenge was 10.1% (95% confidence interval 4.5–15.5). <b><i>Conclusion:</i></b> Future studies assessing the risk of immediate and nonimmediate hypersensitivity reactions to acetaminophen and elucidating the mechanism of acetaminophen hypersensitivity reactions are required.
DOI: 10.6084/m9.figshare.6078299
title: Stable isotope raw data on penguin egg membrane from The rise and fall of an ancient Adélie Penguin ‘supercolony’ at Cape Adare, Antarctica

description: Table S1. Stable isotope results of modern Adélie Penguin egg membrane from Cape Adare, Cape Hallett, Adélie Cove, and Inexpressible Island.
DOI: 10.6084/m9.figshare.6078299.v1
title: Stable isotope raw data on penguin egg membrane from The rise and fall of an ancient Adélie Penguin ‘supercolony’ at Cape Adare, Antarctica

description: Table S1. Stable isotope results of modern Adélie Penguin egg membrane from Cape Adare, Cape Hallett, Adélie Cove, and Inexpressible Island.
DOI: 10.6084/m9.figshare.6078284.v1
title: ZEB1 inhibition sensitizes cells to the ATR inhibitor VE-821 by abrogating epithelial–mesenchymal transition and enhancing DNA damage

description: The ataxia-telangiectasia-mutated (ATM) and rad3-related (ATR) checkpoint pathway plays an essential role in modulating cellular responses to replication stress and DNA damage to maintain genomic stability. In various tumors, cancer cells have increased dependence on ATR signaling for survival, making ATR a promising target for cancer therapy. ATR inhibitors sensitize multiple tumor cell types to radiation and DNA-damaging agents, but application of an ATR inhibitor alone shows limited efficacy. In the present study, we investigated the role of epithelial-to-mesenchymal transition (EMT) and the EMT transcription factor ZEB1 in regulating cell sensitivity to the ATR inhibitor VE-821. We found that VE-821 induced EMT with concomitant ZEB1 upregulation and promoted migration in cells in which the anti-proliferative effect of VE-821 was limited. Knocking down ZEB1 using siRNA partially reversed VE-821-induced EMT, and sensitized cells to VE-821 via effective attenuation of migration and AKT/ERK signaling. Moreover, ZEB1 inhibition promoted Chk1 phosphorylation and induced S-phase arrest by enhancing TopBP1 expression, which suggests a distinctive modulatory effect of ZEB1 on Chk1. Finally, combining VE-821 with ZEB1 inhibition enhanced DNA damage accumulation. These results demonstrate that EMT represents a novel mechanism for limiting the effectiveness of an ATR inhibitor, and thus suggest that ZEB1 inhibition might represent a new approach to increasing the efficiency of, or reversing resistance to, ATR inhibitors.