cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5125852
title: Supplementary Material for: Autologous Collagen-Induced Chondrogenesis Using Fibrin and Atelocollagen Mixture

description: For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture transplanted to cartilage defects. A circular, articular cartilage defect 4 mm in diameter was made in the trochlear region in each of 20 New Zealand white rabbits. The 10 rabbits in the control group were kept without treatment and the 10 rabbits in the experimental group underwent injection of atelocollagen mixed with fibrin. At week 12 following surgery the cartilage was observed and histologically compared in both groups. The surface of the newly generated cartilage was very smooth and even, and we also noted that the entire area was completely regenerated in the experimental group. The control group showed incomplete and irregular cartilage formation in the defect. Regarding the histological scoring, comparison of the two groups differed significantly (p &lt; 0.001). Injection of a mixture of atelocollagen and fibrin used to treat articular cartilage defects of the knee appears to be an effective method for cartilage regeneration.
DOI: 10.6084/m9.figshare.5125855.v1
title: Supplementary Material for: Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies

description: <b><i>Background:</i></b> There is a lack of scientific consensus about cancer comorbidity in people with central nervous system (CNS) disorders. This study assesses the co-occurrence of cancers in patients with CNS disorders, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), autism spectrum disorders, Down's syndrome (DS), Huntington's disease (HD), multiple sclerosis (MS), Parkinson's disease (PD) and schizophrenia (SCZ). <b><i>Method:</i></b> Comprehensive search in PubMed/MEDLINE, Scopus and ISI Web of Knowledge of the literature published before March 2013. We identified 51 relevant articles from 2,229 discrete references, 50 of which contained data suitable for quantitative synthesis (577,013 participants). Pooled effect sizes (ES) were calculated using multiple random-effects meta-analyses. Sources of heterogeneity and uncertainty were explored by means of subgroup and sensitivity analyses, respectively. <b><i>Results:</i></b> The presence of CNS disorders was associated with a reduced co-occurrence of cancer (ES = 0.92; 95% confidence interval, CI: 0.87-0.98; I<sup>2</sup> = 94.5%). A consistently lower overall co-occurrence of cancer was detected in patients with neurodegenerative disorders (ES = 0.80; 95% CI: 0.75- 0.86; I<sup>2</sup> = 82.8%), and in those with AD (ES = 0.32; 95% CI: 0.22-0.46; I<sup>2</sup> = 0.0%), PD (ES = 0.83; 95% CI: 0.76-0.91; I<sup>2</sup> = 80.0%), MS (ES = 0.91; 95% CI: 0.87-0.95; I<sup>2</sup> = 30.3%) and HD (ES = 0.53; 95% CI: 0.42-0.67; I<sup>2</sup> = 56.4%). Patients with DS had a higher overall co-occurrence of cancer (ES = 1.46; 95% CI: 1.08-1.96; I<sup>2</sup> = 87.9%). No association was observed between cancer and ALS (ES = 0.97; 95% CI: 0.76-1.25; I<sup>2</sup> = 0.0%) or SCZ (ES = 0.98; 95% CI: 0.90-1.07; I<sup>2</sup> = 96.3%). Patients with PD, MS and SCZ showed (a) higher co-occurrence of some specific cancers (e.g. PD with melanoma, MS with brain cancers and SCZ with breast cancer), and (b) lower co-occurrence of other specific cancers (e.g. lung, prostate and colorectal cancers in PD; lung and prostate cancers in MS; and melanoma and prostate cancer in SCZ). <b><i>Conclusion:</i></b> Increased and decreased co-occurrence of cancer in patients with CNS disorders represents an opportunity to discover biological and non-biological connections between these complex disorders.
DOI: 10.6084/m9.figshare.5125840
title: Supplementary Material for: Preoperative Serum Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Predict Stabilization of Spontaneously Restored Sinus Rhythm in Persistent Atrial Fibrillation Patients after Mitral Valve Surgery

description: <b><i>Objective:</i></b> The osteoprotegerin (OPG)/receptor activator of nuclear factor-κB (RANK)/RANK ligand (RANKL) axis may play an important role in the stabilization of restored sinus rhythm (SR) after mitral valve (MV) surgery by stimulating atrial fibrillation (AF)-related atrial remodeling in AF patients. Herein, we investigated the association between preoperative serum soluble RANKL (sRANKL)/OPG and<b> </b>the stabilization of restored SR after MV surgery. <b><i>Methods:</i></b> Persistent AF patients who had spontaneously restored SR after MV replacement were enrolled (n = 203). Comparison was made between patients without AF recurrence (n = 71) and patients experiencing recurrence (n = 132). <b><i>Results:</i></b> Patients experiencing recurrence<b> </b>had higher serum levels of sRANKL, OPG and sRANKL/OPG ratio than patients without recurrence. Multivariate survival regression analysis showed that clinical factors such as duration of AF, left atrial diameter and left atrial thrombosis, as well as serum sRANKL level and the sRANKL/OPG ratio, were independent predictors of AF recurrence. Receiver operating characteristic curve analysis showed that the best diagnostic values of the serum sRANKL level and the sRANKL/OPG ratio for predicting recurrence were 3.44 pmol/l and 0.53, respectively. <b><i>Conclusions:</i></b> Patients who had a low preoperative serum sRANKL level and sRANKL/OPG ratio are likely to have a stable spontaneously restored SR postoperatively. Thus, we suggest that patients at high risk of early AF recurrence should be considered for concomitant surgical cardioversion during MV surgery.
DOI: 10.6084/m9.figshare.5125843
title: Supplementary Material for: Characterization of a Fluorescent Probe for Imaging Nitric Oxide

description: <b><i>Background:</i></b> Nitric oxide (NO), a potent vasodilator and anti-atherogenic molecule, is synthesized in various cell types, including vascular endothelial cells (ECs). The biological importance of NO enforces the need to develop and characterize specific and sensitive probes. To date, several fluorophores, chromophores and colorimetric techniques have been developed to detect NO or its metabolites (NO<sub>2</sub> and NO<sub>3</sub>) in biological fluids, viable cells or cell lysates. <b><i>Methods:</i></b> Recently, a novel probe (NO<sub>550</sub>) has been developed and reported to detect NO in solutions and in primary astrocytes and neuronal cells with a fluorescence signal arising from a nonfluorescent background. <b><i>Results:</i></b> Here, we report further characterization of this probe by optimizing conditions for the detection and imaging of NO products in primary vascular ECs, fibroblasts, and embryonic stem cell- and induced pluripotent stem cell-derived ECs in the absence and presence of pharmacological agents that modulate NO levels. In addition, we studied the stability of this probe in cells over time and evaluated its compartmentalization in reference to organelle-labeling dyes. Finally, we synthesized an inherently fluorescent diazo ring compound (AZO<sub>550</sub>) that is expected to form when the nonfluorescent NO<sub>550</sub> reacts with cellular NO, and compared its cellular distribution with that of NO<sub>550</sub>. <b><i>Conclusion:</i></b> NO<sub>550</sub> is a promising agent for imaging NO at baseline and in response to pharmacological agents that modulate its levels.
DOI: 10.6084/m9.figshare.5125846.v1
title: Supplementary Material for: Functional Correlates of Increasing Gestural Articulatory Fluency Using a Miniature Second-Language Approach

description: <b><i>Objectives:</i></b> Gesture-based second languages have become an important tool in the rehabilitation of language-impaired subpopulations. Acquiring the ability to use manual gestures as a means to construct meaningful utterances places unique demands on the brain. This study identified changes in the blood oxygen level-dependent (BOLD) signal associated with the development of gestural fluency using a miniature second-language-based approach. <b><i>Participants and Methods:</i></b> Twelve healthy right-handed adults (19-31 years) were trained to produce sequences of meaningful gestures over a period of 2 weeks. Functional magnetic resonance imaging was used to identify brain regions involved in actual and imagined production of meaningful sentences both before (nonfluent production) and after (fluent production) practice. <b><i>Results:</i></b> Brain areas showing learning-dependent increases in activity associated with the development of fluency included sites associated with language articulation, while learning-related decreases in the BOLD signal were observed in cortical networks associated with motor imagery, and native language processing. <b><i>Conclusion:</i></b> These findings provide novel insights regarding the neural basis of fluency that could inform the design of interventions for treating speech disorders characterized by the loss of fluency.
DOI: 10.6084/m9.figshare.5125849.v1
title: Supplementary Material for: Optimal Intravascular Ultrasound Criteria for Defining the Functional Significance of Intermediate Coronary Stenosis: An International Multicenter Study

description: <b><i>Objective:</i></b> We aimed to assess the ideal cut-off value of minimal lumen area (MLA) by intravascular ultrasound (IVUS) and its diagnostic performance to predict ischemia, using a large-scale, pooled analysis. <b><i>Methods:</i></b> Eleven centers worldwide were invited to provide their clinical, IVUS and fractional flow reserve (FFR) data. A total of 881 lesions were enrolled. <b><i>Results:</i></b> Angiographic % diameter stenosis (r = -0.373, p &lt; 0.0001) and IVUS MLA (r = 0.289, p &lt; 0.0001) correlated with FFR. Best cut-off value (BCV) of IVUS MLA to define the functional significance (FFR &lt;0.8) was 2.75 mm<sup>2</sup> (AUC 0.646, 95% CI 0.609-0.684). When the diagnostic performance of IVUS MLA was tested according to the lesion location, BCV could be found only in lesions in the proximal artery and the mid-left anterior descending artery. Interestingly, Asians (n = 623) and Westerners (n = 258) showed different demographic and lesion characteristics as well as different BCVs to define ischemia. The BCV for the proximal/mid-left anterior descending artery lesions was 2.75 mm<sup>2</sup> (AUC 0.688, 95% CI 0.635-0.742) in Asians and 3.0 mm<sup>2</sup> (AUC 0.695, 95% CI 0.605-0.786) in Westerners. <b><i>Conclusion:</i></b> In this pooled analysis, an IVUS MLA of 2.75 mm<sup>2</sup> was the BCV to define the functional significance of intermediate coronary stenosis. However, when IVUS MLA is used to determine the functional significance, both the lesion and patient characteristics should be considered.
DOI: 10.6084/m9.figshare.5125834
title: Supplementary Material for: A Minimally Invasive Technique for Occluding Large Muscular Ventricular Septal Defects in Infants

description: <b><i>Objective:</i></b> This study investigated the feasibility, timing and indications for closure of large muscular ventricular septal defects (VSDs) in infants without use of a cardiopulmonary bypass. <b><i>Methods:</i></b> A total of 9 infants with large muscular VSDs ranging in size from 7 to 15 mm were treated by minimally invasive closure without cardiopulmonary bypass between April 2010 and February 2013. <b><i>Results:</i></b> All surgeries were successful without resulting in uncontrolled systemic infection, a pulmonary hypertensive crisis or a severely low cardiac output, and with an apparently shorter operation time and postoperative tracheal cannula. <b><i>Conclusions:</i></b> VSD closure without cardiopulmonary bypass can improve the efficacy and prognosis of infants with large muscular VSDs and concurrent pulmonary infections or respiratory failure.
DOI: 10.6084/m9.figshare.5125852.v1
title: Supplementary Material for: Autologous Collagen-Induced Chondrogenesis Using Fibrin and Atelocollagen Mixture

description: For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture transplanted to cartilage defects. A circular, articular cartilage defect 4 mm in diameter was made in the trochlear region in each of 20 New Zealand white rabbits. The 10 rabbits in the control group were kept without treatment and the 10 rabbits in the experimental group underwent injection of atelocollagen mixed with fibrin. At week 12 following surgery the cartilage was observed and histologically compared in both groups. The surface of the newly generated cartilage was very smooth and even, and we also noted that the entire area was completely regenerated in the experimental group. The control group showed incomplete and irregular cartilage formation in the defect. Regarding the histological scoring, comparison of the two groups differed significantly (p &lt; 0.001). Injection of a mixture of atelocollagen and fibrin used to treat articular cartilage defects of the knee appears to be an effective method for cartilage regeneration.
DOI: 10.6084/m9.figshare.5125831
title: Supplementary Material for: Krankheitsrepräsentationen bei nicht-kardialem Brustschmerz - eine verhaltensmedizinische Kurzintervention

description: <b><i>Hintergrund: </i></b>Nicht-kardiale Brustschmerzen sind häufig und entwickeln oft einen chronischen Verlauf. Die einfache ärztliche Rückmeldung über unauffällige kardiodiagnostische Befunde hat sich als nicht ausreichend erwiesen, um dysfunktionale Krankheitsrepräsentationen, Ängste und Sorgen der Betroffenen langfristig zu reduzieren. Daher war das Ziel der Studie, eine niederschwellige, auf subjektive Krankheitsrepräsentationen ausgerichtete psychologische Intervention zu entwickeln und hinsichtlich ihrer Anwendbarkeit zu evaluieren. <b><i>Patienten und Methoden: </i></b>57 Patienten mit nicht-kardialem Brustschmerz nahmen randomisiert an unserer Intervention teil und wurden zu Brustschmerzen und subjektiven Krankheitsrepräsentationen sowie zur subjektiven Bewertung der Intervention befragt. <b><i>Ergebnisse: </i></b>Die Intervention wurde durch die meisten Teilnehmer sehr positiv eingeschätzt («Erfolg versprechend», «weiterzuempfehlen»). Jedoch lehnten vorab 42% der potenziell geeigneten Patienten eine Teilnahme ab. Die Interventionsgruppe war im Gegensatz zu den Refusern jünger, berichtete ungünstige Krankheitsrepräsentationen und größere Brustschmerzintensität. <b><i>Schlussfolgerung: </i></b>Es bleibt eine Herausforderung, Patienten mit nicht-kardialem Brustschmerz mittels verhaltensmedizinischer Interventionen frühzeitig zu erreichen, insbesondere akut weniger beeinträchtigte Personen. Demgegenüber zeigen unsere Ergebnisse, dass eine niederschwellige Intervention realisierbar ist und überwiegend als wirksam eingeschätzt wird.
DOI: 10.6084/m9.figshare.5125837
title: Supplementary Material for: Novel Use of Rituximab for Steroid-Dependent Nephrotic Syndrome in Children

description: <b><i>Background:</i></b> Though rituximab (RTX) is effective for childhood steroid-dependent nephrotic syndrome (SDNS), an established regimen does not exist. The relapses tend to occur when the peripheral blood B-cell count re-arises at 3 months upon single RTX infusion. This study was conducted to clarify whether the long-term remission of SDNS can be obtained by repeated RTX administrations. <b><i>Methods:</i></b> RTX was administered 4 times at 3-month intervals at 375 mg/m<sup>2</sup>/time to 5 children with SDNS. The changes in the clinical indicators were analyzed. <b><i>Results:</i></b> The median (range) observation period was 6.3 (0.9-8.4) years before RTX and 3.2 (1.9-3.8) years following the commencement of RTX. The changes in the clinical indicators were as follows (median and range): (1) annual number of relapses: before administration 1.4 (1.1-3.5) times/year, after administration 0.0 (0.0-0.0) times/year, and (2) median steroid dosage: before administration 0.80 (0.23-0.96) mg/kg/day, after administration 0.00 (0.00-0.00) mg/kg/day. All changes were significant at p &lt; 0.05. Relapse occurred 3 times following the start of RTX (the period to relapse was 2.2, 1.9, and 2.3 years, respectively). No serious side effects were seen. <b><i>Conclusions:</i></b> Repeated RTX against SDNS in children may be a useful therapeutic option.
DOI: 10.6084/m9.figshare.5125840.v1
title: Supplementary Material for: Preoperative Serum Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Predict Stabilization of Spontaneously Restored Sinus Rhythm in Persistent Atrial Fibrillation Patients after Mitral Valve Surgery

description: <b><i>Objective:</i></b> The osteoprotegerin (OPG)/receptor activator of nuclear factor-κB (RANK)/RANK ligand (RANKL) axis may play an important role in the stabilization of restored sinus rhythm (SR) after mitral valve (MV) surgery by stimulating atrial fibrillation (AF)-related atrial remodeling in AF patients. Herein, we investigated the association between preoperative serum soluble RANKL (sRANKL)/OPG and<b> </b>the stabilization of restored SR after MV surgery. <b><i>Methods:</i></b> Persistent AF patients who had spontaneously restored SR after MV replacement were enrolled (n = 203). Comparison was made between patients without AF recurrence (n = 71) and patients experiencing recurrence (n = 132). <b><i>Results:</i></b> Patients experiencing recurrence<b> </b>had higher serum levels of sRANKL, OPG and sRANKL/OPG ratio than patients without recurrence. Multivariate survival regression analysis showed that clinical factors such as duration of AF, left atrial diameter and left atrial thrombosis, as well as serum sRANKL level and the sRANKL/OPG ratio, were independent predictors of AF recurrence. Receiver operating characteristic curve analysis showed that the best diagnostic values of the serum sRANKL level and the sRANKL/OPG ratio for predicting recurrence were 3.44 pmol/l and 0.53, respectively. <b><i>Conclusions:</i></b> Patients who had a low preoperative serum sRANKL level and sRANKL/OPG ratio are likely to have a stable spontaneously restored SR postoperatively. Thus, we suggest that patients at high risk of early AF recurrence should be considered for concomitant surgical cardioversion during MV surgery.
DOI: 10.6084/m9.figshare.5125825
title: Supplementary Material for: Emotions and Memory in Borderline Personality Disorder

description: Memory processes such as encoding, storage, and retrieval of information are influenced by emotional content. Because patients with borderline personality disorder (BPD) are particularly susceptible to emotional information, it is relevant to understand whether such memory processes are altered in this patient group. This systematic literature review collects current evidence on this issue. Research suggests that emotional information interferes more strongly with information processing and learning in BPD patients than in healthy controls. In general, BPD patients do not seem to differ from healthy control subjects in their ability to memorize emotional information, but they tend to have specific difficulties forgetting negative information. Also, BPD patients seem to recall autobiographical, particularly negative events with stronger arousal than healthy controls, while BPD patients also show specific temporo-prefrontal alterations in neural correlates. No substantial evidence was found that the current affective state influences learning and memory in BPD patients any differently than in healthy control subjects. In general, a depressive mood seems to both deteriorate and negatively bias information processing and memories, while there is evidence that dissociative symptoms impair learning and memory independently of stimulus valence. This review discusses methodological challenges of studies on memory and emotions in BPD and makes suggestions for future research and clinical implications.
DOI: 10.6084/m9.figshare.5125834.v1
title: Supplementary Material for: A Minimally Invasive Technique for Occluding Large Muscular Ventricular Septal Defects in Infants

description: <b><i>Objective:</i></b> This study investigated the feasibility, timing and indications for closure of large muscular ventricular septal defects (VSDs) in infants without use of a cardiopulmonary bypass. <b><i>Methods:</i></b> A total of 9 infants with large muscular VSDs ranging in size from 7 to 15 mm were treated by minimally invasive closure without cardiopulmonary bypass between April 2010 and February 2013. <b><i>Results:</i></b> All surgeries were successful without resulting in uncontrolled systemic infection, a pulmonary hypertensive crisis or a severely low cardiac output, and with an apparently shorter operation time and postoperative tracheal cannula. <b><i>Conclusions:</i></b> VSD closure without cardiopulmonary bypass can improve the efficacy and prognosis of infants with large muscular VSDs and concurrent pulmonary infections or respiratory failure.
DOI: 10.6084/m9.figshare.5125837.v1
title: Supplementary Material for: Novel Use of Rituximab for Steroid-Dependent Nephrotic Syndrome in Children

description: <b><i>Background:</i></b> Though rituximab (RTX) is effective for childhood steroid-dependent nephrotic syndrome (SDNS), an established regimen does not exist. The relapses tend to occur when the peripheral blood B-cell count re-arises at 3 months upon single RTX infusion. This study was conducted to clarify whether the long-term remission of SDNS can be obtained by repeated RTX administrations. <b><i>Methods:</i></b> RTX was administered 4 times at 3-month intervals at 375 mg/m<sup>2</sup>/time to 5 children with SDNS. The changes in the clinical indicators were analyzed. <b><i>Results:</i></b> The median (range) observation period was 6.3 (0.9-8.4) years before RTX and 3.2 (1.9-3.8) years following the commencement of RTX. The changes in the clinical indicators were as follows (median and range): (1) annual number of relapses: before administration 1.4 (1.1-3.5) times/year, after administration 0.0 (0.0-0.0) times/year, and (2) median steroid dosage: before administration 0.80 (0.23-0.96) mg/kg/day, after administration 0.00 (0.00-0.00) mg/kg/day. All changes were significant at p &lt; 0.05. Relapse occurred 3 times following the start of RTX (the period to relapse was 2.2, 1.9, and 2.3 years, respectively). No serious side effects were seen. <b><i>Conclusions:</i></b> Repeated RTX against SDNS in children may be a useful therapeutic option.
DOI: 10.6084/m9.figshare.5125828
title: Supplementary Material for: Impact of <b><i>TNF </i></b>Haplotypes in the Physical Course of Acne Vulgaris

description: <b><i>Background:</i></b> The role of single-nucleotide polymorphisms (SNPs) of the <i>TNF </i>gene in acne vulgaris remains controversial. <b><i>Methods:</i></b> Genomic DNA was isolated from 185 patients with acne vulgaris and 165 healthy controls. SNPs at positions -376, -308 and -238 of the promoter region of <i>TNF </i>were defined. <b><i>Results:</i></b> The frequency of the GAG haplotype was greater among patients (16.8%) than among controls with borderline significance (9.7%, p = 0.059). Male carriers of haplotypes other than GGG presented acne vulgaris at a later age than carriers of the GGG haplotype. No effect of the GAG haplotype on the frequency of acne conglobata was found among women with polycystic ovary syndrome. <b><i>Conclusions:</i></b> Carriage of the GAG haplotype of <i>TNF</i> is linked with borderline susceptibility to acne vulgaris. The GGG haplotype is related with earlier disease onset in male patients.