cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8987141.v1
title: A novel simplified scoring system for predicting mortality in emergency colorectal surgery: prediction model development

description: ABSTRACT BACKGROUND: Despite advances in surgical approaches, emergency colorectal surgery has high mortality and morbidity. OBJECTIVE: We aimed to create a simple and distinctive scoring system, for predicting mortality among patients undergoing emergency colorectal surgery. DESIGN AND SETTING: Prediction model development study based on retrospective data-gathering. METHODS: Patients who underwent emergency colorectal surgery between March 2014 and December 2016 at a single tertiary-level referral center were included in our study. Patient demographics, comorbidities, type of surgery, etiology and laboratory and radiological findings were collected retrospectively and analyzed. A new clinical score (named the Numune emergency colorectal resection score) was constructed from the last logistic regression model, in which one point was assigned for the presence of each predictive factor. RESULTS: 138 patients underwent emergency colorectal surgery. These comprised 64 males (46.4%) and 74 females (53.6%), with a mean age of 64 years. Multivariate analysis revealed that blood urea nitrogen level &gt; 65 mg/dl (odds ratio, OR: 8.03; 95% confidence interval, CI: 2.16-15.77), albumin level &lt; 0.7 mg/dl (OR: 4.43; 95% CI: 1.96-14.39) and American Society of Anesthesiologists score ≥ 3 (OR: 3.47; 95% CI: 0.81-9.18) were associated with postoperative complications. The Numune score was graded from I to III. The risk of mortality was found to be 63.2% in the group with grade III, which accounted for 35.2% of the subjects. There were 37 postoperative deaths. CONCLUSIONS: Surgeons need scoring systems, especially to predict postoperative mortality. We propose the Numune emergency colorectal resection score for emergency surgical procedures as a practical, usable and effective system for predicting postoperative morbidity.
DOI: 10.6084/m9.figshare.8987132
title: Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population

description: ABSTRACT Objective The increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults. Subjects and methods The present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms. Results The prevalence of overweight was higher among men, whereas obesity was more prevalent among women. However, the frequency of ACE or AGT polymorphisms was similar among body mass index (BMI) categories. In addition, the mean age-adjusted BMI averages did not change significantly for ACE or AGT polymorphisms, regardless of sex or BMI category. The age-adjusted BMI average for the combination of ACE and AGT genotypes evidenced no significant differences regardless of sex or BMI categories. Results were similar when BMI was replaced by waist circumference (WC). Conclusions We were not able to find any associations between BMI and WC (overweight/obesity) and ACE and AGT polymorphisms, indicating that the RAS system might not be involved in overweight and obesity, at least based on genetic backgrounds. However, further studies must measure RAS components to elucidate this question.
DOI: 10.6084/m9.figshare.8987132.v1
title: Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population

description: ABSTRACT Objective The increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults. Subjects and methods The present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms. Results The prevalence of overweight was higher among men, whereas obesity was more prevalent among women. However, the frequency of ACE or AGT polymorphisms was similar among body mass index (BMI) categories. In addition, the mean age-adjusted BMI averages did not change significantly for ACE or AGT polymorphisms, regardless of sex or BMI category. The age-adjusted BMI average for the combination of ACE and AGT genotypes evidenced no significant differences regardless of sex or BMI categories. Results were similar when BMI was replaced by waist circumference (WC). Conclusions We were not able to find any associations between BMI and WC (overweight/obesity) and ACE and AGT polymorphisms, indicating that the RAS system might not be involved in overweight and obesity, at least based on genetic backgrounds. However, further studies must measure RAS components to elucidate this question.
DOI: 10.6084/m9.figshare.8987135.v1
title: Youth overweight/obesity and its relationship with cardiovascular disease and parental risk factors

description: ABSTRACT Objective The prevalence of overweight and obesity is gradually increasing in both developed and developing countries. Obesity, for instance, can present multifactorial causes that interact with each other. Among the important factors, parental obesity plays a prominent role in the onset of obesity during childhood and teenage years through genetics and ambient aspects. This study aims to verify the possible existence of an association between overweight/obesity of schoolchildren and cardiovascular risk (CVR) factors for their parents. Subjetcs and methods For this purpose, a cross-sectional study was conducted with a sample of 1,243 children and adolescents, aged between 7 and 17. Out of the total number of participants, 563 (45.3%) were boys who were selected across 19 schools in the urban and rural areas of Santa Cruz do Sul, Rio Grande do Sul (Brazil). The overweight/obesity status of the schoolchildren was evaluated through their body mass index (BMI). Additionally, a self-reference questionnaire was employed to measure their parents’ CVR. Results The results of this study revealed that students with overweight/obesity have a higher probability of having a father with hypertension (OR = 1.49; p = 0.038) and obesity (OR = 2.36; p = 0.002) and a mother with obesity (OR = 1.72; p = 0.016). Conclusion To conclude, this study confirms a relationship between overweight/obesity of schoolchildren with CVR for their parents.
DOI: 10.6084/m9.figshare.8987120
title: From the “hole” to the tourist attractive: a sociology of rural resignification

description: Abstract: This article aims to discuss the contemporary transformations of the rural based on the resignification phenomenon of nature and the environment. The article will be based on a case study about the representations of nature in Brotas, city located in the central region of São Paulo state. In this city, the elective affinity between the professionalization of adventure tourism, environmental issues and the discursive resignification of the rural was responsible for an important transformation of the locality from the 1990s to the first decade of the 21st century. The specific theme to be discussed in this case is the creation of an “object of nature” which has begun to characterize the rural in Brotas – namely the waterfalls, that previously was stigmatized as “holes”, and later transformed into environmental attractions endowed with economic value.
DOI: 10.6084/m9.figshare.8987114
title: Comparative study between monoexponential and biexponential diffusion weighted imaging sequences in multiparametric prostate magnetic resonance imaging

description: ABSTRACT Objective: To compare qualitatively and quantitatively, in terms of image quality, a new biexponential diffusion sequence protocol with the standard monoexponential diffusion protocol on multiparametric prostate magnetic resonance imaging. Methods: This study had a prospective data collection and cross-sectional analysis. Between August and November 2017, a total of 70 patients who underwent multiparametric prostate magnetic resonance imaging due to clinical suspicion of prostatic neoplasia were recruited. The images obtained were evaluated by two independent readers regarding subjective/qualitative criteria (six criteria) and objective/quantitative criteria (three criteria), always comparing the monoexponential to biexponential acquisition protocols. The results were compared by statistical analysis (interobserver agreement − Gwet coefficient; analysis of the qualitative variables − Stuart-Maxwell test; and analysis of the quantitative variables − Wilcoxon test). Results: After exclusion of four patients, the final sample consisted of 66 patients. A good/excellent inter observer agreement was stablished for subjective criteria (except in one criteria). For the qualitative analysis the amount of good or excellent evaluations was higher for the monoexponential protocol (except in one category), with evidence of significant differences for three criteria (diffusion weighted imaging global quality; diffusion weighted imaging signal-to-noise ratio; and apparent diffusion coefficient signal-to-noise ratio). For the quantitative data analysis, the monoexponential protocol showed less variability of the anteroposterior diameters, meaning less distortion of the images, and better estimated signal-to-noise ratio. Conclusion: In our data, the quality of the images of the monoexponential standard diffusion sequence was qualitatively and quantitatively superior to those of the biexponential diffusion weighted imaging sequence.
DOI: 10.6084/m9.figshare.8987120.v1
title: From the “hole” to the tourist attractive: a sociology of rural resignification

description: Abstract: This article aims to discuss the contemporary transformations of the rural based on the resignification phenomenon of nature and the environment. The article will be based on a case study about the representations of nature in Brotas, city located in the central region of São Paulo state. In this city, the elective affinity between the professionalization of adventure tourism, environmental issues and the discursive resignification of the rural was responsible for an important transformation of the locality from the 1990s to the first decade of the 21st century. The specific theme to be discussed in this case is the creation of an “object of nature” which has begun to characterize the rural in Brotas – namely the waterfalls, that previously was stigmatized as “holes”, and later transformed into environmental attractions endowed with economic value.
DOI: 10.6084/m9.figshare.8987111
title: Metrics of benthic communities and habitat quality associated to different types of land use

description: ABSTRACT Aquatic ecosystems are under severe anthropogenic modifications. Thus, the dependent biological communities in these environments are also changed. The objective of this study was to investigate the effects of urban development in a highly impacted ecosystem. We selected 15 sampling points along the stream Ribeirão Vermelho, in which were sampled benthic macroinvertebrates and assessed the water and habitat diversity. It was found an impact gradient, with some the reference points classified as natural and others as impacted. There was a significant difference in all biological indicators used. The total number of taxa, the wealth of Diptera, the taxa Ephemeroptera, Plecoptera and Trichoptera, and the diversity indices, the Water Quality Indices, and the percentage of herbivores crushers and predators were significantly higher in points classified as natural and changed. The relative abundances of collectors, filter feeding, chironomids and parasites were significantly lower in sites classified as natural in relation to impacted ones. The metrics of the macroinvertebrate community benthic and Habitat Diversity Protocol were influenced by environmental degradation, being a useful tool for planning and development actions for the preservation of watersheds and the prioritization of high-value transmission systems for protection and rehabilitation of aquatic ecosystems
DOI: 10.6084/m9.figshare.8987114.v1
title: Comparative study between monoexponential and biexponential diffusion weighted imaging sequences in multiparametric prostate magnetic resonance imaging

description: ABSTRACT Objective: To compare qualitatively and quantitatively, in terms of image quality, a new biexponential diffusion sequence protocol with the standard monoexponential diffusion protocol on multiparametric prostate magnetic resonance imaging. Methods: This study had a prospective data collection and cross-sectional analysis. Between August and November 2017, a total of 70 patients who underwent multiparametric prostate magnetic resonance imaging due to clinical suspicion of prostatic neoplasia were recruited. The images obtained were evaluated by two independent readers regarding subjective/qualitative criteria (six criteria) and objective/quantitative criteria (three criteria), always comparing the monoexponential to biexponential acquisition protocols. The results were compared by statistical analysis (interobserver agreement − Gwet coefficient; analysis of the qualitative variables − Stuart-Maxwell test; and analysis of the quantitative variables − Wilcoxon test). Results: After exclusion of four patients, the final sample consisted of 66 patients. A good/excellent inter observer agreement was stablished for subjective criteria (except in one criteria). For the qualitative analysis the amount of good or excellent evaluations was higher for the monoexponential protocol (except in one category), with evidence of significant differences for three criteria (diffusion weighted imaging global quality; diffusion weighted imaging signal-to-noise ratio; and apparent diffusion coefficient signal-to-noise ratio). For the quantitative data analysis, the monoexponential protocol showed less variability of the anteroposterior diameters, meaning less distortion of the images, and better estimated signal-to-noise ratio. Conclusion: In our data, the quality of the images of the monoexponential standard diffusion sequence was qualitatively and quantitatively superior to those of the biexponential diffusion weighted imaging sequence.
DOI: 10.6084/m9.figshare.8987111.v1
title: Metrics of benthic communities and habitat quality associated to different types of land use

description: ABSTRACT Aquatic ecosystems are under severe anthropogenic modifications. Thus, the dependent biological communities in these environments are also changed. The objective of this study was to investigate the effects of urban development in a highly impacted ecosystem. We selected 15 sampling points along the stream Ribeirão Vermelho, in which were sampled benthic macroinvertebrates and assessed the water and habitat diversity. It was found an impact gradient, with some the reference points classified as natural and others as impacted. There was a significant difference in all biological indicators used. The total number of taxa, the wealth of Diptera, the taxa Ephemeroptera, Plecoptera and Trichoptera, and the diversity indices, the Water Quality Indices, and the percentage of herbivores crushers and predators were significantly higher in points classified as natural and changed. The relative abundances of collectors, filter feeding, chironomids and parasites were significantly lower in sites classified as natural in relation to impacted ones. The metrics of the macroinvertebrate community benthic and Habitat Diversity Protocol were influenced by environmental degradation, being a useful tool for planning and development actions for the preservation of watersheds and the prioritization of high-value transmission systems for protection and rehabilitation of aquatic ecosystems
DOI: 10.6084/m9.figshare.8987096
title: Coordination, cooperation and collaboration in logistics and supply chains: a bibliometric analysis

description: Abstract Paper aims This paper identifies, evaluates and structures the research that focuses on supply chain coordination, cooperation and collaboration (CCC) within the domain of production economics and reveals its intellectual foundation. Originality The paper develops a distinct CCC-model, which enables a clear distinction between the elements of CCC based on five criteria. Afterwards, it presents the most influential papers and authors when it comes to CCC in supply chain production economics research. It also provides a visualised intellectual structure of five citation subfields and their interrelations. Research method Based on the reference list of more than 270 CCC-related papers, the authors perform a citation and co-citation analysis of the 47 most frequently cited papers in one selected academic journal. This analysis included multidimensional scaling, factor analysis as well as cluster analysis. Main findings The study reveals the intellectual base of CCC in a production economic-specific research domain, which reflects coordination only. The citation clusters represent different aspects of supply chain coordination mechanisms such as contractual agreements, information sharing and buyer-vendor integration. One subfield represents methodological aspects. Implications for theory and practice Neither cooperation nor collaboration related sources were identified in the most frequently used papers which certainly offers a research gap that needs to be closed in the future.
DOI: 10.6084/m9.figshare.8987099
title: Sensitivity, advantages, limitations, and clinical utility of targeted next-generation sequencing panels for the diagnosis of selected lysosomal storage disorders

description: Abstract Lysosomal storage disorders (LSDs) constitute a heterogeneous group of approximately 50 genetic disorders. LSDs diagnosis is challenging due to variability in phenotype penetrance, similar clinical manifestations, and a high allelic heterogeneity. A powerful tool for the diagnosis of the disease could reduce the “diagnostic odyssey” for affected families, leading to an appropriate genetic counseling and a better outcome for current therapies, since enzyme replacement therapies have been approved in Brazil for Gaucher, Fabry, and Pompe diseases, and are under development for Niemann-Pick Type B. However, application of next-generation sequencing (NGS) technology in the clinical diagnostic setting requires a previous validation phase. Here, we assessed the application of this technology as a fast, accurate, and cost-effective method to determine genetic diagnosis in selected LSDs. We have designed two panels for testing simultaneously 11 genes known to harbor casual mutations of LSDs. A cohort of 58 patients was used to validate those two panels, and the clinical utility of these gene panels was tested in four novel cases. We report the assessment of a NGS approach as a new tool in the diagnosis of LSDs in our service.
DOI: 10.6084/m9.figshare.8987096.v1
title: Coordination, cooperation and collaboration in logistics and supply chains: a bibliometric analysis

description: Abstract Paper aims This paper identifies, evaluates and structures the research that focuses on supply chain coordination, cooperation and collaboration (CCC) within the domain of production economics and reveals its intellectual foundation. Originality The paper develops a distinct CCC-model, which enables a clear distinction between the elements of CCC based on five criteria. Afterwards, it presents the most influential papers and authors when it comes to CCC in supply chain production economics research. It also provides a visualised intellectual structure of five citation subfields and their interrelations. Research method Based on the reference list of more than 270 CCC-related papers, the authors perform a citation and co-citation analysis of the 47 most frequently cited papers in one selected academic journal. This analysis included multidimensional scaling, factor analysis as well as cluster analysis. Main findings The study reveals the intellectual base of CCC in a production economic-specific research domain, which reflects coordination only. The citation clusters represent different aspects of supply chain coordination mechanisms such as contractual agreements, information sharing and buyer-vendor integration. One subfield represents methodological aspects. Implications for theory and practice Neither cooperation nor collaboration related sources were identified in the most frequently used papers which certainly offers a research gap that needs to be closed in the future.
DOI: 10.6084/m9.figshare.8987099.v1
title: Sensitivity, advantages, limitations, and clinical utility of targeted next-generation sequencing panels for the diagnosis of selected lysosomal storage disorders

description: Abstract Lysosomal storage disorders (LSDs) constitute a heterogeneous group of approximately 50 genetic disorders. LSDs diagnosis is challenging due to variability in phenotype penetrance, similar clinical manifestations, and a high allelic heterogeneity. A powerful tool for the diagnosis of the disease could reduce the “diagnostic odyssey” for affected families, leading to an appropriate genetic counseling and a better outcome for current therapies, since enzyme replacement therapies have been approved in Brazil for Gaucher, Fabry, and Pompe diseases, and are under development for Niemann-Pick Type B. However, application of next-generation sequencing (NGS) technology in the clinical diagnostic setting requires a previous validation phase. Here, we assessed the application of this technology as a fast, accurate, and cost-effective method to determine genetic diagnosis in selected LSDs. We have designed two panels for testing simultaneously 11 genes known to harbor casual mutations of LSDs. A cohort of 58 patients was used to validate those two panels, and the clinical utility of these gene panels was tested in four novel cases. We report the assessment of a NGS approach as a new tool in the diagnosis of LSDs in our service.