cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22268609.v1
title: Exosomes secreted from bone marrow mesenchymal stem cells suppress cardiomyocyte hypertrophy through Hippo-YAP pathway in heart failure

description: Abstract Mesenchymal stem cells-derived exosomes (MSCs-exosomes) reportedly possess cardioprotective effects. This study investigated the therapeutic potential and mechanisms of MSCs-exosomes on heart failure (HF). H9c2 cells were used to establish a cardiomyocyte hypertrophy model by angiotensin II (Ang II) treatment. Isolated MSCs-exosomes were identified by transmission electron microscope and CD63 detection. Apoptosis rate was measured by terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay. Levels of inflammatory factors [interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF)-α] and brain natriuretic peptide (BNP) were determined by ELISA. Expression of apoptosis-related proteins [Bax, B-cell lymphoma-2 (Bcl-2), and caspase 3] and Hippo-Yes-associated protein (YAP) pathway-related proteins [YAP, phosphor (p)-YAP, and tafazzin (TAZ)] was detected by western blotting. Cardiomyocyte hypertrophy of H9c2 cells induced by Ang II was ameliorated by MSCs-exosomes treatment. MSCs-exosomes downregulated Bax and caspase 3 levels and upregulated Bcl-2 level in Ang II-induced H9c2 cells. MSCs-exosomes also reduced the levels of BNP, IL-1β, IL-4, IL-6, and TNF-α in Ang II-induced H9c2 cells. Meanwhile, p-YAP was downregulated and TAZ was upregulated after MSCs-exosomes administration. In conclusion, MSCs-exosomes alleviate the apoptosis and inflammatory response of cardiomyocyte via deactivating Hippo-YAP pathway in HF.
DOI: 10.6084/m9.figshare.21744245
title: Concentration and gene expression analyses of dragon′s blood flavonoids in different tissues of Dracaena cochinchinensi

description: ABSTRACT Background: Dragon′s blood is a well-known traditional Chinese medicine, isolated mainly from the trunks of Dracaena trees. Overexploitation of the Dracaena resource has resulted in this plant becoming endangered. This work aimed to assess the potential to use various tissues of the Dracaena cochinchinensis tree, such as leaves and roots, to produce dragon′s blood. Results: We found that many dragon′s blood components accumulated in the bark of trunk and roots of D. cochinchinensis under natural conditions. In addition, small amounts of loureirin A were detected in leaves, suggesting that the leaves could be a potential source of dragon′s blood. Real-time quantitative PCR analysis showed that most of the genes tested in this study, which encoded enzymes involved in the biosynthesis of dragon′s blood flavonoids, were highly expressed in the bark of roots and trunk. Conclusion: We confirmed that the bark of roots and trunk of D. cochinchinensis tree were the main tissues for the synthesis and storage of dragon′s blood under natural conditions. This study demonstrated the potential to extract dragon′s blood from the roots that have been abandoned due to mining difficulties without destroying the tree, a process which would be beneficial to the protection of the endangered wild D. cochinchinensis tree populations.
DOI: 10.6084/m9.figshare.21744245.v1
title: Concentration and gene expression analyses of dragon′s blood flavonoids in different tissues of Dracaena cochinchinensi

description: ABSTRACT Background: Dragon′s blood is a well-known traditional Chinese medicine, isolated mainly from the trunks of Dracaena trees. Overexploitation of the Dracaena resource has resulted in this plant becoming endangered. This work aimed to assess the potential to use various tissues of the Dracaena cochinchinensis tree, such as leaves and roots, to produce dragon′s blood. Results: We found that many dragon′s blood components accumulated in the bark of trunk and roots of D. cochinchinensis under natural conditions. In addition, small amounts of loureirin A were detected in leaves, suggesting that the leaves could be a potential source of dragon′s blood. Real-time quantitative PCR analysis showed that most of the genes tested in this study, which encoded enzymes involved in the biosynthesis of dragon′s blood flavonoids, were highly expressed in the bark of roots and trunk. Conclusion: We confirmed that the bark of roots and trunk of D. cochinchinensis tree were the main tissues for the synthesis and storage of dragon′s blood under natural conditions. This study demonstrated the potential to extract dragon′s blood from the roots that have been abandoned due to mining difficulties without destroying the tree, a process which would be beneficial to the protection of the endangered wild D. cochinchinensis tree populations.
DOI: 10.6084/m9.figshare.14391351
title: Additional file 18 of The reference genome and transcriptome of the limestone langur, Trachypithecus leucocephalus, reveal expansion of genes related to alkali tolerance

description: Additional file 18: Table S13. The annotation of special genes in the genome of T. leucocephalus.
DOI: 10.6084/m9.figshare.18585682
title: Additional file 4 of An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin

description: Additional file 4: Supplementary Table 3.
DOI: 10.6084/m9.figshare.14391360
title: Additional file 20 of The reference genome and transcriptome of the limestone langur, Trachypithecus leucocephalus, reveal expansion of genes related to alkali tolerance

description: Additional file 20: Table S15. The annotation of contracted gene families in the genome of T. leucocephalus.
DOI: 10.34740/kaggle/dsv/7626403
title: Forex Exchange Rates Since 2004 (Updated Daily)
DOI: 10.6084/m9.figshare.22268627
title: Wind Erosion Resistance Effect of Conservation Tillage: The Case of Chestnut Soil in Mongolian Plateau

description: ABSTRACT &gt;To quantitatively evaluate the effect of stubble height and mulching on soil resistance to wind erosion in protected cultivated chestnut soil farmland under different wind speed conditions, tests were carried out on conservation and conventional tillage in Mongolian Plateau, China, using a mobile wind erosion wind tunnel. Chestnut soils were a soil type in fragile semi-arid ecosystems that were susceptible to desertification following wind erosion and were found mainly in Central Asia and the North American continent. The results show that soil erosion on conservation tillage was lower than conventional tillage at different wind speeds. The resistance of conservation tillage to soil wind erosion increases with increasing stubble height and cover. At a stubble height of 300 mm and 50% cover, conservation tillage's average wind erosion resistance efficiency was 74.82%, effectively preventing wind erosion of agricultural soils.
DOI: 10.6084/m9.figshare.22268609
title: Exosomes secreted from bone marrow mesenchymal stem cells suppress cardiomyocyte hypertrophy through Hippo-YAP pathway in heart failure

description: Abstract Mesenchymal stem cells-derived exosomes (MSCs-exosomes) reportedly possess cardioprotective effects. This study investigated the therapeutic potential and mechanisms of MSCs-exosomes on heart failure (HF). H9c2 cells were used to establish a cardiomyocyte hypertrophy model by angiotensin II (Ang II) treatment. Isolated MSCs-exosomes were identified by transmission electron microscope and CD63 detection. Apoptosis rate was measured by terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay. Levels of inflammatory factors [interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF)-α] and brain natriuretic peptide (BNP) were determined by ELISA. Expression of apoptosis-related proteins [Bax, B-cell lymphoma-2 (Bcl-2), and caspase 3] and Hippo-Yes-associated protein (YAP) pathway-related proteins [YAP, phosphor (p)-YAP, and tafazzin (TAZ)] was detected by western blotting. Cardiomyocyte hypertrophy of H9c2 cells induced by Ang II was ameliorated by MSCs-exosomes treatment. MSCs-exosomes downregulated Bax and caspase 3 levels and upregulated Bcl-2 level in Ang II-induced H9c2 cells. MSCs-exosomes also reduced the levels of BNP, IL-1β, IL-4, IL-6, and TNF-α in Ang II-induced H9c2 cells. Meanwhile, p-YAP was downregulated and TAZ was upregulated after MSCs-exosomes administration. In conclusion, MSCs-exosomes alleviate the apoptosis and inflammatory response of cardiomyocyte via deactivating Hippo-YAP pathway in HF.
DOI: 10.6084/m9.figshare.14391363.v1
title: Additional file 21 of The reference genome and transcriptome of the limestone langur, Trachypithecus leucocephalus, reveal expansion of genes related to alkali tolerance

description: Additional file 21: Table S16. Annotation analysis of positive selected genes related to alkaline ion metabolism of T. leucocephalus.
DOI: 10.3886/icpsr06570.v1
title: Study of Ambulatory Care Sensitive Diagnoses as a Monitor of Primary Access, 1993: [California]
title: Version 1

description: The purpose of this study was to examine whether higher hospital admission rates for chronic medical conditions result from community differences in access to care, prevalence of the chronic medical conditions, propensity to seek care, or physician admitting style. In multiple California communities, five chronic medical conditions were studied: asthma, chronic obstructive pulmonary disease, congestive heart failure, diabetes mellitus, and hypertension. This collection includes data from two surveys, one of adults in the communities (Part 1, Community Health Care Survey Data), and the other of physicians who provide adult primary care in the same communities (Part 3, Physician Practice Survey Data). Topics covered included respondent self-report of access to care in the community (including health insurance status, whether the respondent had a regular source of care, and specific and overall difficulties in obtaining care), respondent propensity to seek care (how important the respondent thought it was to see a physician for each of five major symptoms), physician predisposition to hospitalize patients, and physician responsiveness to patients' social factors (such as whether the patient was an alcoholic or an IV drug user, uninsured, homeless, lived alone, or was covered by Medicaid). Demographic variables include sex, race, education, household income, and marital status.
description: Datasets: 
 
 DS0: Study-Level Files 
 DS1: Community Health Care Survey Data 
 DS2: Community Health Care Survey Data in SAS Transport Format 
 DS3: Physician Practice Survey Data 
 DS4: Physician Practice Survey Data in SAS Transport Format
description: The codebook is provided as a Portable Document Format (PDF) file. The PDF file format was developed by Adobe Systems Incorporated and can be accessed using PDF reader software, such as the Adobe Acrobat Reader. Information on how to obtain a copy of the Acrobat Reader is provided through the ICPSR Website on the Internet.
description: Community Health Care Survey: English- and Spanish-speaking adults between the ages of 18 and 64 years living in California for a minimum of three months. Physician Practice Survey: California providers of primary adult care (general internists, family physicians, general practitioners) and emergency physicians listed in the American Medical Association Physician Masterfile.
description: Community Health Care Survey: 2,656 California ZIP codes were aggregated into 250 urban and 144 rural ZIP-code clusters. Using random-digit dialing, households were selected from a stratified random sample of 52 of these 394 clusters. Within households, respondents were randomly selected from among eligible adults. Physician Practice Survey: all emergency physicians in selected clusters, and either a total of 30 or 25 percent of the primary care physicians in selected clusters, whichever was larger. Some physicians from outside the selected clusters were also sampled.
DOI: 10.3886/icpsr06570.v2
title: Study of Ambulatory Care Sensitive Diagnoses as a Monitor of Primary Access, 1993: [California]
title: Version 2

description: The purpose of this study was to examine whether higher 
 hospital admission rates for chronic medical conditions result from 
 community differences in access to care, prevalence of the chronic 
 medical conditions, propensity to seek care, or physician admitting 
 style. In multiple California communities, five chronic medical 
 conditions were studied: asthma, chronic obstructive pulmonary disease, 
 congestive heart failure, diabetes mellitus, and hypertension. This 
 collection includes data from two surveys, one of adults in the 
 communities (Part 1, Community Health Care Survey Data), and the other 
 of physicians who provide adult primary care in the same communities 
 (Part 3, Physician Practice Survey Data). Topics covered included 
 respondent self-report of access to care in the community (including 
 health insurance status, whether the respondent had a regular source of 
 care, and specific and overall difficulties in obtaining care), 
 respondent propensity to seek care (how important the respondent 
 thought it was to see a physician for each of five major symptoms), 
 physician predisposition to hospitalize patients, and physician 
 responsiveness to patients' social factors (such as whether the patient 
 was an alcoholic or an IV drug user, uninsured, homeless, lived alone, 
 or was covered by Medicaid). Demographic variables include sex, race, 
education, household income, and marital status.
description: Community Health Care Survey: 2,656 California ZIP codes 
 were aggregated into 250 urban and 144 rural ZIP-code clusters. Using 
 random-digit dialing, households were selected from a stratified random 
 sample of 52 of these 394 clusters. Within households, respondents were 
 randomly selected from among eligible adults. Physician Practice 
 Survey: all emergency physicians in selected clusters, and either a 
 total of 30 or 25 percent of the primary care physicians in selected 
 clusters, whichever was larger. Some physicians from outside the 
selected clusters were also sampled.
description: Datasets: 
DS0: Study-Level Files
DS1: Community Health Care Survey Data
DS2: Community Health Care Survey Data in SAS Transport Format
DS3: Physician Practice Survey Data
DS4: Physician Practice Survey Data in SAS Transport Format
description: Community Health Care Survey: English- and Spanish-speaking 
 adults between the ages of 18 and 64 years living in California for a 
 minimum of three months. Physician Practice Survey: California 
 providers of primary adult care (general internists, family physicians, 
 general practitioners) and emergency physicians listed in the American 
Medical Association Physician Masterfile.
description: The codebook is provided as a Portable Document Format
 (PDF) file. The PDF file format was developed by Adobe Systems
 Incorporated and can be accessed using PDF reader software, such as
 the Adobe Acrobat Reader. Information on how to obtain a copy of the
Acrobat Reader is provided through the ICPSR Website on the Internet.
DOI: 10.6084/m9.figshare.22268684
title: Oxidative damage and exocrine dysfunction of ovine fetal pancreas are induced by maternal nutritional restriction

description: ABSTRACT This study investigated oxidative damage and exocrine dysfunction of fetal pancreas caused by maternal nutritional restriction. Eighteen ewes carrying singleton fetus were randomly divided into control group (CG, ad libitum, 0.67 MJ ME/BW0.75/d, n = 6), restricted group 1 (RG1, 0.33 MJ ME/BW0.75/d, n = 6), and restricted group 2 (RG2, 0.18 MJ ME/BW0.75/d, n = 6) at d 90 of pregnancy. Maternal undernutrition was imposed from d 90 to 140 of pregnancy. At 140 d of gestation, fetal blood and pancreas tissue were collected to determine fetal pancreatic extracellular matrix, antioxidant capacity, and indicators of exocrine dysfunction. With the decrease of maternal nutrition, the fetal body weight, pancreatic weight, and DNA content were reduced in RG2 compared with CG, and increased and thickened collagen fibers were observed in RG2. Fetuses in RG2 exhibited increased collagen 3 (COL3) and fibronectin (FN) levels relative to CG, and the COL1:COL3 ratio was lower than that of the CG. For RG1, we found increased COL3 compared with CG. Malondialdehyde, serum amylase, and serum lipase in fetal pancreas in RG2 increased, but the total antioxidant capacity (T-AOC) decreased compared with the CG. The impaired ovine fetal pancreas growth, antioxidant imbalance, and pancreatic exocrine dysfunction are induced by maternal undernutrition during late pregnancy.
DOI: 10.6084/m9.figshare.22268684.v1
title: Oxidative damage and exocrine dysfunction of ovine fetal pancreas are induced by maternal nutritional restriction

description: ABSTRACT This study investigated oxidative damage and exocrine dysfunction of fetal pancreas caused by maternal nutritional restriction. Eighteen ewes carrying singleton fetus were randomly divided into control group (CG, ad libitum, 0.67 MJ ME/BW0.75/d, n = 6), restricted group 1 (RG1, 0.33 MJ ME/BW0.75/d, n = 6), and restricted group 2 (RG2, 0.18 MJ ME/BW0.75/d, n = 6) at d 90 of pregnancy. Maternal undernutrition was imposed from d 90 to 140 of pregnancy. At 140 d of gestation, fetal blood and pancreas tissue were collected to determine fetal pancreatic extracellular matrix, antioxidant capacity, and indicators of exocrine dysfunction. With the decrease of maternal nutrition, the fetal body weight, pancreatic weight, and DNA content were reduced in RG2 compared with CG, and increased and thickened collagen fibers were observed in RG2. Fetuses in RG2 exhibited increased collagen 3 (COL3) and fibronectin (FN) levels relative to CG, and the COL1:COL3 ratio was lower than that of the CG. For RG1, we found increased COL3 compared with CG. Malondialdehyde, serum amylase, and serum lipase in fetal pancreas in RG2 increased, but the total antioxidant capacity (T-AOC) decreased compared with the CG. The impaired ovine fetal pancreas growth, antioxidant imbalance, and pancreatic exocrine dysfunction are induced by maternal undernutrition during late pregnancy.
DOI: 10.6084/m9.figshare.22792886
title: Additional file 1 of The effect of type 2 diabetes mellitus on the prognosis of osteoporotic vertebral compression fracture with osteoporotic fracture classification after vertebroplasty

description: Additional file 1: Title of data: Fractured segments. Description of data: Fractured segments of every included de-identified participant in the T2DM and control group.
DOI: 10.6084/m9.figshare.22792886.v1
title: Additional file 1 of The effect of type 2 diabetes mellitus on the prognosis of osteoporotic vertebral compression fracture with osteoporotic fracture classification after vertebroplasty

description: Additional file 1: Title of data: Fractured segments. Description of data: Fractured segments of every included de-identified participant in the T2DM and control group.
DOI: 10.34740/kaggle/dsv/7626420
title: Top Spotify Songs in 73 Countries (Daily Updated)
DOI: 10.6084/m9.figshare.16305595.v1
title: Additional file 6 of Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

description: Additional file 6: Data 3. List of independent eQTLs
DOI: 10.6084/m9.figshare.16305595
title: Additional file 6 of Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

description: Additional file 6: Data 3. List of independent eQTLs
DOI: 10.6084/m9.figshare.21220145.v1
title: Additional file 5 of Liquid biopsy using ascitic fluid and pleural effusion supernatants for genomic profiling in gastrointestinal and lung cancers

description: Additional file 5: Supplementary Table 2. Actionable mutations detected in different specimens among 139 lung cancer patients.
DOI: 10.6084/m9.figshare.16305601.v1
title: Additional file 8 of Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

description: Additional file 8: Table 2. meQTLs functional analysis obtained with enrichR R package. Enrichment analysis of KEGG, GO and Reactome databases. For each term of the data base, the number of genes found in meQTLs/number of genes associated to the term (Overlap), the proportion test p-value, adjusted p-value and combined score and the genes in meQTLs that are included in the list of genes associated to the term.
DOI: 10.6084/m9.figshare.22268739
title: Study on vibration isolation performance of composite multilayer wave impeding block based on wave impedance ratio under an underground dynamic load

description: Abstract Based on the theory of single-phase elastic medium and unsaturated porous medium, the vibration isolation effect of composite multilayer wave impeding block (WIB) in the unsaturated ground under an underground dynamic load is investigated. The results show that the best vibration isolation effect can be obtained by designing the wave impedance ratio between the composite multilayer WIB and unsaturated ground. The composite multilayer WIB improves the vibration-damping bandwidth compared with the homogeneous WIB. The vibration isolation effect is better the closer the embedded depth of the composite multilayer WIB is to the vibration source, and its vibration isolation effect increases significantly with the increase of thickness, but when the thickness of the WIB exceeds a certain critical thickness, its vibration isolation effect decreases with the increase of thickness. Soil saturation has a significant effect on the vibration isolation effect of composite multilayer WIB in the unsaturated ground, and the composite multilayer WIB can achieve a better vibration isolation effect at low saturation.
DOI: 10.6084/m9.figshare.22268739.v1
title: Study on vibration isolation performance of composite multilayer wave impeding block based on wave impedance ratio under an underground dynamic load

description: Abstract Based on the theory of single-phase elastic medium and unsaturated porous medium, the vibration isolation effect of composite multilayer wave impeding block (WIB) in the unsaturated ground under an underground dynamic load is investigated. The results show that the best vibration isolation effect can be obtained by designing the wave impedance ratio between the composite multilayer WIB and unsaturated ground. The composite multilayer WIB improves the vibration-damping bandwidth compared with the homogeneous WIB. The vibration isolation effect is better the closer the embedded depth of the composite multilayer WIB is to the vibration source, and its vibration isolation effect increases significantly with the increase of thickness, but when the thickness of the WIB exceeds a certain critical thickness, its vibration isolation effect decreases with the increase of thickness. Soil saturation has a significant effect on the vibration isolation effect of composite multilayer WIB in the unsaturated ground, and the composite multilayer WIB can achieve a better vibration isolation effect at low saturation.
DOI: 10.6084/m9.figshare.16305601
title: Additional file 8 of Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

description: Additional file 8: Table 2. meQTLs functional analysis obtained with enrichR R package. Enrichment analysis of KEGG, GO and Reactome databases. For each term of the data base, the number of genes found in meQTLs/number of genes associated to the term (Overlap), the proportion test p-value, adjusted p-value and combined score and the genes in meQTLs that are included in the list of genes associated to the term.