cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1181739.v4
title: Modulation of Cis-Trans Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines

description: 2-Substituted N-acyl-piperidine is a widespread and important structural motif, found in nearly 500 currently available structures, and present in at least 30 pharmaceutically active compounds. Restricted rotation of the acyl substituent in such molecules can give rise to two distinct chemical environments. Here we demonstrate using NMR studies and modelling of the lowest energy structures of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine derivatives that the amide cis-trans equilibrium is affected by intramolecular hydrogen bonding between the amide oxygen and adjacent aromatic protons. Structural predictions were used to design molecules that promote either the cis- or trans-amide conformation; thereby compounds with a tailored conformational ratio were prepared as proven by NMR studies. Analysis of the available X-ray data of a variety of the published N-acyl-piperidine containing compounds further indicates that these molecules are also clustered in the two observed conformations. This finding emphasizes that the reported directed conformational isomerism has significant implications for the design of both small molecules and larger amide-containing molecular architectures.
DOI: 10.6084/m9.figshare.21644414.v1
title: C388601-TGA Test Report.pdf

description: Thermogravemetric Analysis for " Piezoresistive Composites in Tension and Compression using a Cantilevered Beam for Spot Testing and Tactile Sensing."
DOI: 10.6084/m9.figshare.22180012.v2
title: Tables

description: <strong>Table 1.</strong> General Characteristics of the included studies (n=18)
DOI: 10.17632/rrjm5v27dz
title: Data for: Tracing the isotopic signatures of cryospheric water and establishing the altitude effect in Central Himalayas: a tool for cryospheric water partitioning

description: This data file contains a One-year (2017) data of stable isotopes for water [deuterium (2H) and oxygen-18 (18O)] from River, precipitation, glacial ice, Supra glacial channel and Lake water for Alaknanda river in Satopanth glacier basin at Central Himalayan region, India. There are 275 records with spatial and temporal variation in the basin.
DOI: 10.6084/m9.figshare.28588856.v1
title: e-cig data coded, separate responses.xlsx

description: this data belongs to a research aims to investigate the use of e-cigarettes and the three-dimensional impact of pychosocio-ecenomic factors on its use among young adults.
DOI: 10.6084/m9.figshare.27079990.v1
title: Supplementary Material for: Study of rates and factors associated to psychosomatic syndromes assessed using the Diagnostic Criteria for Psychosomatic Research across different clinical settings

description: Introduction: Diagnostic Criteria for Psychosomatic Research (DCPR) serve as an instrument for identifying and classifying specific psychosomatic syndromes that are not adequately encompassed in standard nosography. The present study aimed at measuring the prevalence of DCPR syndromes in different clinical settings and exploring factors associated to such diagnoses.
Methods: A cross-sectional and nationwide study recruited 6,647 patients in different clinical settings: 306 were diagnosed with fibromyalgia (FM), 333 with irritable bowel syndrome (IBS), 1,109 with migraine, 2,550 with coronary heart disease (CHD), and 2,349 with type 2 diabetes (T2D). Participants underwent DCPR diagnostic interview and were assessed for depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder 7-Item Scale), and subjective well-being (World Health Organization-5 Well-Being Index). The PsychoSocial Index was used to evaluate global well-being, stress, and abnormal illness behavior. The prevalence of DCPR diagnoses was calculated, and factors associated to such diagnoses were analyzed by logistic regression. 
Results: Alexithymia (64.47%), irritable mood (20.55%), and demoralization (15.60%) were the most prevalent psychosomatic syndromes, with demoralization being most common in FM (49.02%). The factors associated to DCPR diagnoses encompassed high anxiety or abnormal illness behavior, and poor well-being. Notably, stress was found to be associated specifically to FM and T2D, with OR of 1.24 (95% CI: 1.06-1.46) and 1.26 (95% CI: 1.18-1.36), respectively.
Conclusion: DCPR is a clinically helpful complementary assessment tool in need of being widely implemented in clinical settings in order to have a comprehensive picture of the patients.
DOI: 10.6084/m9.figshare.3529070.v1
title: Appendix C. Components of population-level variation in acorn production.

description: Components of population-level variation in acorn production.
DOI: 10.6084/m9.figshare.24760245.v1
title: Mammalian Mito-ER Images

description: Mito-BFP (Addgene, Voeltz Lab, 49151) was used for visualization of mitochondria and GFP-Sec61b (Addgene, Rapoport Lab, 15108) was used for visualization of the endoplasmic reticulum (ER).
DOI: 10.17632/6phjx8s467
title: Data for: Enhanced antitumor effects of CD123/CD33 dual-antibody modified liposome targeting to acute myeloid leukemia cells with reduced the antigen-negative escape

description: A dual-targeting drug delivery system was developoed to enhance the therapeutic efficacy of chemotherapeutics and reduce the antigen-negative escape for Acute myeloid leukemia.
DOI: 10.6084/m9.figshare.5120623.v1
title: Supplementary Material for: Isolation, Culture and Characterization of Cardiac Progenitor Cells Derived from Human Embryonic Heart Tubes

description: A variety of studies have reported on the isolation and expansion of cardiac stem cells from adult hearts. However, there is little information concerning cardiac stem/progenitor cells derived from embryonic hearts/heart tubes. To provide more evidence for embryonic heart-derived stem/progenitor cells, Nkx2.5+ human cardiac progenitorcells (hCPCs) were isolated and cloned from human heart tubes. The cells stained positive for Nkx2.5 and Oct-4, and negative for α-smooth muscle actin (α-SMA), cytokeratin, factor-VIII, α-sarcomeric actin and c-Kit. GATA-4 expression of Nkx2.5+ hCPCs was higher than that of embryonic limb bud mesenchymal cells of the control group (p &lt; 0.05). These cells were passaged continuously for &gt;3 months (23 passages) and proliferated actively in vitro. After being treated with 5-azacytidine, Nkx2.5+ hCPCs underwent cardiomyogenic differentiation. Ultrastructural observation confirmed that the longitudinal section of these cardiomyogenic differentiation cells clearly revealed typical sarcomeres and intercalated discs. α-MHC, α-sarcomeric actin and GATA-4 levels were increased in Nkx2.5+ hCPCs treated with 5-azacytidine compared to untreated cells. Nkx2.5+ hCPCs exhibited positive staining and had a higher expression for α-SMA when cocultured with canine vascular endothelial cells. After Nkx2.5+ hCPCs were treated with endothelin-1, all cells displayed spontaneous electrical activity and spontaneous beating. Connexin-40 and -45 were stained positive in the treated cells. In conclusion, Nkx2.5+ hCPCs derived from heart tubes have been isolated and cloned in vitro. These cells are capable of long-term self-renewal and possess a potential to differentiate into cardiac muscle-like cells, cardiac pacemaking cells and smooth muscle-like cells. They could have a significant impact on cardiac regeneration medicine and developmental biology.
DOI: 10.6084/m9.figshare.12991376.v1
title: Mammal_Data.xls

description: Data set of medium and large-sized mammals and landscape structure in southeastern Brazil.
DOI: 10.6084/m9.figshare.19664283.v1
title: Supplementary Material for: Neuroprotection in the Striatum of Hypoxic-Ischemic Piglets by Simultaneous Inhibition of Dopamine D1 and Adenosine A<sub>2A</sub> Receptors

description: <b><i>Introduction:</i></b> Striatal neurons of term newborns are highly vulnerable to hypoxia-ischemia (H-I). In a piglet model of H-I, a dopamine D1 receptor antagonist and an adenosine A<sub>2A</sub> receptor antagonist alone preferentially protect striatonigral and striatopallidal neurons, respectively. Here, we tested the hypothesis whether the combined treatment with SCH23390, a D1 receptor antagonist, and SCH58261, an A<sub>2A</sub> receptor antagonist, is more efficacious than individual D1 and A<sub>2A</sub> receptor antagonist treatment. <b><i>Methods:</i></b> Anesthetized newborn piglets were subjected to sham operation (<i>n</i> = 6) or 40 min of hypoxia and 7 min of airway occlusion. At 5 min of reoxygenation, piglets received the vehicle, SCH23390, SCH58261, or the combined treatment (<i>n</i> = 9 in each group). At 4 days of recovery, the number of viable neurons in the entire putamen was estimated by unbiased stereology. <b><i>Results:</i></b> Stereological results showed that sham-operated piglets had an estimated 2.9 × 10<sup>6</sup> neurons in the putamen, and the number of viable neurons in hypoxic-ischemic piglets was significantly reduced by 80% to 0.6 × 10<sup>6</sup>/putamen. Treatment with SCH23390, SCH58261, and the combination increased the numbers of viable neurons to 1.4 × 10<sup>6</sup>/putamen, 1.4 × 10<sup>6</sup>/putamen, and 2.1 × 10<sup>6</sup>/putamen, respectively. Notably, the combined treatment improved neuroprotection compared to individual therapy. <b><i>Conclusion:</i></b> We conclude that simultaneous inhibition of dopamine D1 receptors and adenosine A<sub>2A</sub> receptors saves more neurons than individual treatment in the highly vulnerable putamen of a large-animal neonatal H-I model.
DOI: 10.6084/m9.figshare.7330430.v1
title: Human Convalescent Serum Sample after CHIKV and DENV seroconversion.

description: Human Convalescent Serum Sample collected after CHIKV and DENV seroconversion.
DOI: 10.6084/m9.figshare.10343747.v1
title: Comorbidity associated with Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but does not affect the parasite cycle in mice

description: Ascariasis is considered the most neglected tropical disease, and is a major problem for the public health system. However, idiopathic pulmonary fibrosis (IPF) is a result of chronic extracellular deposition of matrix in the pulmonary parenchyma, and thickening of the alveolar septa, which reduces alveolar gas exchange. Considering the high rates of ascariasis and pulmonary fibrosis, we believe that these two diseases may co-exist and possibly lead to comorbidities. We therefore investigated the mechanisms involved in comorbidity of <i>Ascaris suum </i>(<i>A. suum</i>) infection, which could interfere with the progression of pulmonary fibrosis. In addition, we evaluated whether a previous lung fibrosis could interfere with the pulmonary cycle of <i>A. suum</i> in mice. The most important findings related to comorbidity in which <i>A. suum</i> infection exacerbated pulmonary and liver injury, inflammation and dysfunction, but did not promote excessive fibrosis in mice during the investigated comorbidity period. Interestingly, we found that pulmonary fibrosis did not alter the parasite cycle that transmigrated preferentially through preserved but not fibrotic areas of the lungs. Collectively, our results demonstrate that <i>A. suum</i> infection leads to comorbidity, and contributes to the aggravation of pulmonary dysfunction during pulmonary fibrosis, which also leads to significant liver injury and inflammation, without changing the <i>A. suum</i> cycle in the lungs.<br>
DOI: 10.6084/m9.figshare.7332845.v3
title: Signatures of selection in admixed dairy cattle in Tanzania

description: This is plink binary data supporting conclusions in the article "<b>Signatures of selection in admixed dairy cattle in Tanzania"</b>. The first column of the .fam file are the dummy family IDs.
DOI: 10.6084/m9.figshare.c.3305517_d266.v1
title: Cells MDA-MB-231 (4).bmp

description: Mock-transfected MDA-MB-231 cells
DOI: 10.17632/sx2s29jf95
title: Images of the lungs of Syrian hamsters and Table of the body weight raw data 

description: Images of the lungs of Syrian hamsters on the day 3 and on the day 6 after SARS-CoV-2 infection. 

Body weight of the animals. Animals were weighed on day 0 (before the experiment), then on days 6, 13, 20, 27, 34 and 41 of the experiment. When weighing, four animals were randomly selected from each group to determine body weight (five weightings per group). The data of each weighting and an average body weight of one animal (mean±SD) are represented for each group.
DOI: 10.6084/m9.figshare.23267351.v1
title: Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

description: We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women (n = 517) with metagenomics (n = 499), targeted metabolomics (n = 500) and whole-genome sequencing (n = 500) to identify novel microbiome-related biomarkers for bone health. We also performed metagenomics in a US whites cohort for validation (n = 59).The characteristics of the cohorts, genome-wide association study (GWAS) data, concentrations of serum short chain fatty acids (SCFAs), relative abundance of gut microbiota and gut microbiota-associated functional KEGG modules are shown in this dataset.The sequencing data of the Chinese cohort (whole genome sequencing and metagenomics) can be found in “Genome Sequence Archive for Human” (https://ngdc.cncb.ac.cn/gsa-human, accession No. HRA004900). The metagenomic sequencing data can be found in “Sequence Read Archive” (https://www.ncbi.nlm.nih.gov/sra, accession No. PRJNA986283 and PRJNA1011937).
DOI: 10.6084/m9.figshare.7222775.v1
title: Runtime metrics data of 7 different RNA-Seq quantification workflows

description: Runtime metrics data of 7 different RNA-seq workflows on 6 instance types of Amazon Web Service Elastic Compute Cloud. The workflow descriptions in Common Workflow Language are available on GitHub (https://github.com/pitagora-network/pitagora-cwl).
DOI: 10.17632/43rcbgrhyr
title: LINF_130016500

description: Patatin-like protein; Leishmania infantum (strain JPCM5)
DOI: 10.6084/m9.figshare.10013468.v1
title: Nicholson_etal_2019_Wild_bee_specimen_records

description: These data are individual specimen records. These specimens were collected via aerial hand netting along transects on fruit farms. Fruit farms were located in California (watermelon), Michigan (blueberry and cherry), and Oregon (blueberry). Farms were either 'treated' with a pollinator habitat enhancement (i.e. 'enhanced edge') or an edge was left unplanted (i.e. 'control edge). SpecimenS were collected at these 'edge' habitats and in enhanced and control crops. See Methods section in Nicholson et al 2019 <i>Ecology Letters</i> for more info.<br><br>Column names follow Darwin Core standard terms:<br>https://dwc.tdwg.org/terms/<br><br>
DOI: 10.17632/w84gwxgbtm
title: Dataset for 'Satellite based Budyko framework reveals the human imprint on long-term surface water partitioning across India'

description: The folder 'Fitting_Budyko_Parameter' contains codes and data for obtaining calibrated values of Tixeront-Fu's omega from long-term mean annual precipitation, potential evapotranspiration, and actual evapotranspiration. Codes for performing a split sample test to check the performance of the omega calibration are also in the same folder. Data for the remaining portion of the analysis is extracted from 'ProcessedData.xlsx'. The file contains all physio-climatic and socio-economic characteristics used for analysis. 'CorrelationAnalysis.r' is used to generate correlograms for identifying correlated characteristics. Intra-category correlations are identified from generated correlograms to shortlist characteristics. Further correlations are eliminated by examining a combined correlogram having factors from all categories. 'Main_Code.r' calls the functions 'CART_func.r' and 'RF_func.r' iteratively for each omega threshold defined in 'CART_RF_Model_Thresholds.xlsx'. Pruned and unpruned trees for class prediction are extracted as outputs from 'CART_func.r'. Pruning is done using the 1-SE rule (Breiman et al., 1984) Pruned trees are used to develop a circos plot using the online tool on ‘http://mkweb.bcgsc.ca/tableviewer/visualize/’. Factor predictive importance computed using permutation of variable importance quantification is obtained from 'RF_func.r'. The function also generates confusion matrices indicating the categorization performance of each model trained. Outputs are written to the 'Outputs' folder in accordingly named sub-folders
DOI: 10.6084/m9.figshare.25772202.v1
title: Choice Experiment Data

description: Data set for the tree planting DCE and diversion channels DCE, and their do-file are contained in the zip provided
DOI: 10.6084/m9.figshare.28280831.v1
title: RoB2 signaling question for PAH

description: Phosphodiesterase type 5 inhibitor plus endothelin receptor antagonist compared to either alone for group 1 pulmonary arterial hypertension
DOI: 10.6084/m9.figshare.28875926.v1
title: Arctic Horizon Scan - Derived Potential New Alien Species

description: This dataset includes species downloaded from GBIF and was used to identify potential new alien species in the Arctic Horizon Scan.
DOI: 10.17632/n47ddcz9nr
title: Dataset for "Evaluation of air quality and mobility policies in 14 large Italian cities from 2006 to 2016"

description: Data on air quality and mobility in the 14 Italian metropolitan cities from 2006 to 2016. The cities are: Bari, Bologna, Cagliari, Florence, Genoa, Messina, Milan, Naples, Palermo, Reggio Calabria, Rome, Turin and Venice. For each year and each city, air quality data are: concentration and exceedances of NO2, PM10 and PM2.5 in traffic and background monitoring stations. For each year and each city, mobility data are: the number of vehicles, motorbikes, trucks and tractors, divided by environmental classification (i.e. Euro 0, Euro 1, Euro 2, Euro 3, Euro 4, Euro 5, Euro 6) and by fuel type (i.e. petrol, gasoil, liquified petroleum gas LPG, compressed natural gas CNG, hybrid and electric cars); public transport offer and demand, divided by type (i.e. wheel, rail and water). The number of inhabitants and the municipality surface are also provided for each year and each city.
DOI: 10.6084/m9.figshare.26417230.v1
title: Psychological Flexibility Music and Science 2024

description: Dataset for Viator et al 2024
DOI: 10.6084/m9.figshare.897917.v6
title: Data from: Two complete mitochondrial genome sequences of white-spotted char Salvelinus leucomaenis (Salmoniformes: Salmonidae)

description: Results of the analysis of the complete mitochondrial genomes of <em>Salvelinus</em> (Salmonidae) species for evidence of recombination using various recombination detection methods implemented in the Recombination Detection Program (RDP4) (Martin et al., 2010). The comparison of KF974451–KF974452 sequences of mitochondrial genome of white-spotted char <em>S. leucomaenis</em> (Shedko, 2014) and KF513161 sequence of mitochondrial genome of <em>S. leucomaenis</em> (Zhang et al., 2013) as well as NC_000860 (<em>S. fontinalis</em>), NC_000861 (<em>S. alpinus</em>) and KC897653 (<em>Parahucho perryi</em>) sequences by using the RDP4 software (Martin et al., 2010) revealed that the KF513161 sequence is a combination of sequences from two distinct (4.9% divergence) mitochondrial DNA lineages – lineage of <em>S. fontinalis</em>, represented by NC_000860 sequence (positions 1000–15,359 and 15,869–16,337 in KF513161 sequence; 0.2% divergence) and white-spotted char, represented by the KF974451 and KF974452 sequences (positions 15,360–15,868 and 16,338–999 in KF513161 sequence; 0.6–1.0% divergence).
DOI: 10.6084/m9.figshare.14825193.v1
title: GRAZPEDWRI-DX

description: The GRAZPEDWRI-DX dataset contains 20,327 wrist trauma images that were annotated by pediatric radiologists. These annotations include objects and tags of fractures, fracture classifications, and several other relevant image descriptors.
DOI: 10.6084/m9.figshare.22753637.v2
title: Pollinator visits tomato flowers in blocks with imidacloprid sprayed once and twice weekly and control block.

description: Pollinator visits to tomato flowers in blocks with imidacloprid sprayed once and twice a week and control block.
DOI: 10.6084/m9.figshare.21865209.v3
title: Association between depressive symptoms and physical inactivity in technical-administrative workers at a public university in Northeastern Brazil

description: <strong>Objective:</strong> to investigate the association between depressive symptoms and physical inactivity in technical-administrative workers at a public university in Northeastern Brazil. <strong>Methods:</strong> cross-sectional study, carried out with technical-administrative workers at a public university in the State of Bahia. Depressive symptoms were assessed using the Patient Health Questionnaire-9 instrument and the level of physical activity using the International Physical Activity Questionnaire. Logistic regression analysis was performed and the magnitude of the association was estimated by calculating the odds ratio (OR), adopting a 95% confidence interval as a measure of precision. <strong>Results:</strong> 301 civil servants participated in the study and, among these, 214 (71.1%) were women. The prevalence of depressive symptoms was 25.7% and 52.0% of employees declared themselves to be physically inactive. Depressive symptoms and physical inactivity were associated according to the effect modifiers working time at the institution ≤ 15 years (RP=3.03; 95% CI: 1.05; 9.16) and capacity in administrative sectors (PR= 1.90; 95% CI: 1.14; 3.18). <strong>Conclusion:</strong> the need for adaptations in organizational management and the creation of effective programs to encourage the potential benefits for health and well-being provided by the performance of physical activities in the work environment was evidenced.
DOI: 10.6084/m9.figshare.19915108.v1
title: INJURIES BY FATIGUE FROM AEROBIC TRAINING IN JUMPING ATHLETES

description: ABSTRACT Introduction The increasingly tense and aggressive competition in the competitive sports field has led to a continuous increase in the athletes’ exercise load. Sports injuries resulting from this increased load are also increasing. Research in this area helps prevent jumping sports injuries and guides protocols for treatment. Currently, research on sports injuries in athletics jumping events is relatively rare. Objective This paper examines sports injuries in sport jumping athletes. Methods This article investigates injuries in 16 vault athletes with 5 to 10 years of training. Results Distance jumping is a significant risk factor for anterior cruciate ligament injuries. The risk of injury when landing on one foot is more significant than when landing on both feet. Especially when the body is in a state of neuromuscular fatigue, this will significantly increase the risk of anterior cruciate ligament injury. Conclusion Excessive local exercise load, incorrect technical movements, and physical fatigue are the leading causes of sports injuries. Coaches should organize training and competitions reasonably. Athletes need to reinforce the protection of the knees, ankles, and other frequently injured parts. Evidence Level II; Therapeutic Studies - Investigating the result.
DOI: 10.15468/dl.c7fp44
title: Occurrence Download

description: A dataset containing 368517 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tephritidae"
 ]
}

 The dataset includes 368517 records from 791 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009411-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15251298
title: OʻQITUVCHINING FAOLIYATIDA METODLARNING TUTGAN OʻRNI
DOI: 10.5281/zenodo.15251299
title: OʻQITUVCHINING FAOLIYATIDA METODLARNING TUTGAN OʻRNI