cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3469475.v2
title: Feasibility of binary composition in development of nanoethosomal glycolic vesicles of triamcinolone acetonide using Box-behnken design: <i>in vitro</i> and <i>ex vivo</i> characterization

description: Triamcinolone acetonide (TA) employed for the treatment of atopic dermatitis exhibits limited penetration into the epidermis. This investigation <b>aimed</b> to explore the role of binary solvents in topical drug delivery of TA by developing nanoethosomal glycolic lipid vesicles by infusion method. Screening of vesicles (TA1-TA17) formulated by Box Behnken design identified the optimized formulation (TA10) that was developed as carbomer gels. The gels were then evaluated for pharmaceutical properties and compared with control and reference ethosomal gel (RG). Higher <i>in vitro</i> permeation was found in gels containing TA10, prepared with or without using penetration enhancer (EGP 83.76 ± 0.72% and EG 82.42 ± 0.89%, respectively). CLSM studies depicted deeper uniform penetration of fluorescent tracer into the epidermis via EG as compared with RG and control gel. Enhanced penetration was due to combinational solvent effect exerted by ethanol and propylene glycol. Histological analysis confirmed the non-irritant potential of the gel. Thus, it can be concluded that nanoethosomal glycolic vesicles proved to be an effective non irritant carrier for improvised penetration of triamcinolone acetonide for potential topical therapeutics.
DOI: 10.6084/m9.figshare.3469466
title: DFT study of the reaction between TBD, 4-methyl benzylalcohol initiator, and one molecule of 1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose (ring-opening polymerization initiation step)

description: Data to support article: Polymers from Sugars and CO<sub>2</sub>: Synthesis and Polymerization of a ᴅ-Mannose-Based Cyclic Carbonate <sub></sub> DOI: 10.6084/m9.figshare.3469466 <br> Authors: Georgina L. Gregory, <sup>[a] [b]</sup> Liliana M. Jenisch,<sup>[a]</sup> Bethan Charles, <sup>[a] [b]</sup> Gabriele Kociok-Köhn<sup>[c] </sup>and Antoine Buchard<sup>[a] </sup>*<sup><br></sup> <sup>[a] Department of Chemistry, University of Bath, Bath BA2 7AY, UK<br>[b] EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK<br>[c] Chemical Characterisation and Analysis Facility (CCAF), University of Bath, Bath BA2 7AY, UK</sup>DFT study: - DFT optimized geometries and computed free enthalpies of local minima (intermediates) and local maxima (transition states) were used to investigate the mechanism of the reaction between TBD, 4-methylbenzyl alcohol and 1 molecule of D-mannose based monomer<b> 1 </b>(1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose)<b><sub> </sub></b>to account for the initiation step of ring-opening polymerization.<b><sub><br></sub></b> Protocols: <br>rwB97XD/6-311++G(d,p)/6-31+G(d)cpcm=dichloromethane/T=298.15K<br> Content: - Gaussian09 rev D.01 output files- ROP_initiation.pdf, illustrating the calculations made and summarizing the free enthalpies computed.
DOI: 10.6084/m9.figshare.3469466.v1
title: DFT study of the reaction between TBD, 4-methyl benzylalcohol initiator, and one molecule of 1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose (ring-opening polymerization initiation step)

description: Data to support article: Polymers from Sugars and CO<sub>2</sub>: Synthesis and Polymerization of a ᴅ-Mannose-Based Cyclic Carbonate <sub></sub> DOI: 10.6084/m9.figshare.3469466 <br> Authors: Georgina L. Gregory, <sup>[a] [b]</sup> Liliana M. Jenisch,<sup>[a]</sup> Bethan Charles, <sup>[a] [b]</sup> Gabriele Kociok-Köhn<sup>[c] </sup>and Antoine Buchard<sup>[a] </sup>*<sup><br></sup> <sup>[a] Department of Chemistry, University of Bath, Bath BA2 7AY, UK<br>[b] EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK<br>[c] Chemical Characterisation and Analysis Facility (CCAF), University of Bath, Bath BA2 7AY, UK</sup>DFT study: - DFT optimized geometries and computed free enthalpies of local minima (intermediates) and local maxima (transition states) were used to investigate the mechanism of the reaction between TBD, 4-methylbenzyl alcohol and 1 molecule of D-mannose based monomer<b> 1 </b>(1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose)<b><sub> </sub></b>to account for the initiation step of ring-opening polymerization.<b><sub><br></sub></b> Protocols: <br>rwB97XD/6-311++G(d,p)/6-31+G(d)cpcm=dichloromethane/T=298.15K<br> Content: - Gaussian09 rev D.01 output files- ROP_initiation.pdf, illustrating the calculations made and summarizing the free enthalpies computed.
DOI: 10.6084/m9.figshare.3469373
title: DFT study of the thermodynamics of the reactions between 1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose and methanol or iso-propanol

description: Data to support article: Polymers from Sugars and CO<sub>2</sub>: Synthesis and Polymerization of a ᴅ-Mannose-Based Cyclic Carbonate <br><sub></sub> DOI: 10.6084/m9.figshare.3469373 <br> Authors: Georgina L. Gregory, <sup>[a] [b]</sup> Liliana M. Jenisch,<sup>[a]</sup> Bethan Charles, <sup>[a] [b]</sup> Gabriele Kociok-Köhn<sup>[c] </sup>and Antoine Buchard<sup>[a] </sup>*<sup><br></sup> <sup>[a] Department of Chemistry, University of Bath, Bath BA2 7AY, UK<br>[b] EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK<br>[c] Chemical Characterisation and Analysis Facility (CCAF), University of Bath, Bath BA2 7AY, UK</sup>DFT study: - DFT optimized geometries and computed free enthalpies were used to calculate the thermodynamics of the ring-opening of D-mannose based monomer<b> 1 </b>(1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose) or D-glucose counterpart monomer <b>1<sub>G </sub></b>(from Mikami et al., J. Am. Chem. Soc. 2013, 135, 6826), by methanol or iso-propanol, to evaluate the regioselectivity of the reactions. <b><sub><br></sub></b> Protocols: <br>rwB97XD/6-311++G(2d,p)/cpcm=dichloromethane/T=298.15KrM06-2X-D3/6-311++G(2d,p)/cpcm=dichloromethane/T=298.15K Content: - Gaussian09 rev D.01 output files- Thermodynamics and regioselectivity of ring-opening.pdf, illustrating the calculations made and summarizing the free enthalpies computed.
DOI: 10.6084/m9.figshare.3469373.v1
title: DFT study of the thermodynamics of the reactions between 1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose and methanol or iso-propanol

description: Data to support article: Polymers from Sugars and CO<sub>2</sub>: Synthesis and Polymerization of a ᴅ-Mannose-Based Cyclic Carbonate <br><sub></sub> DOI: 10.6084/m9.figshare.3469373 <br> Authors: Georgina L. Gregory, <sup>[a] [b]</sup> Liliana M. Jenisch,<sup>[a]</sup> Bethan Charles, <sup>[a] [b]</sup> Gabriele Kociok-Köhn<sup>[c] </sup>and Antoine Buchard<sup>[a] </sup>*<sup><br></sup> <sup>[a] Department of Chemistry, University of Bath, Bath BA2 7AY, UK<br>[b] EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK<br>[c] Chemical Characterisation and Analysis Facility (CCAF), University of Bath, Bath BA2 7AY, UK</sup>DFT study: - DFT optimized geometries and computed free enthalpies were used to calculate the thermodynamics of the ring-opening of D-mannose based monomer<b> 1 </b>(1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose) or D-glucose counterpart monomer <b>1<sub>G </sub></b>(from Mikami et al., J. Am. Chem. Soc. 2013, 135, 6826), by methanol or iso-propanol, to evaluate the regioselectivity of the reactions. <b><sub><br></sub></b> Protocols: <br>rwB97XD/6-311++G(2d,p)/cpcm=dichloromethane/T=298.15KrM06-2X-D3/6-311++G(2d,p)/cpcm=dichloromethane/T=298.15K Content: - Gaussian09 rev D.01 output files- Thermodynamics and regioselectivity of ring-opening.pdf, illustrating the calculations made and summarizing the free enthalpies computed.
DOI: 10.6084/m9.figshare.3469283
title: DFT study of the thermodynamics of the reaction between dimethyl carbonate and 1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose

description: Data to support article: Polymers from Sugars and CO<sub>2</sub>: Synthesis and Polymerization of a ᴅ-Mannose-Based Cyclic Carbonate <br><sub></sub> DOI: 10.6084/m9.figshare.3469283 <br> Authors: Georgina L. Gregory, <sup>[a] [b]</sup> Liliana M. Jenisch,<sup>[a]</sup> Bethan Charles, <sup>[a] [b]</sup> Gabriele Kociok-Köhn<sup>[c] </sup>and Antoine Buchard<sup>[a] </sup>*<sup><br></sup> <sup>[a] Department of Chemistry, University of Bath, Bath BA2 7AY, UK<br>[b] EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK<br>[c] Chemical Characterisation and Analysis Facility (CCAF), University of Bath, Bath BA2 7AY, UK</sup>DFT study: - DFT optimized geometries and computed enthalpies were used to calculate the thermodynamics of the isodesmic reactions between dimethyl carbonate and D-mannose based monomer<b> 1 </b>(1-O-methyl-2,3-O-isopropylidene-4,6-O-carbonate-α-ᴅ-mannopyranose) or D-glucose counterpart monomer <b>1<sub>G </sub></b>(from Mikami et al., J. Am. Chem. Soc. 2013, 135, 6826), so as to evaluate the ring-strains of the 2 monomers.<b><sub><br></sub></b> Protocols: <br>rwB97XD/6-311+G(2d,p)/cpcm=dichloromethane/T=298.15KrM06-2X-D3/6-311+G(2d,p)/cpcm=dichloromethane/T=298.15K Content: - Gaussian09 rev D.01 output files- Ring_Strain_Evaluation.pdf, illustrating the calculations made and summarizing the enthalpies computed.<br>
DOI: 10.6084/m9.figshare.3469199
title: Sulphate Ancillary Metadata and Processing Metadata and Scripts

description: The contents of this project includes the processing scripts and required meta data to generate UM sulphate emissions ancillary files from the ECLIPSE v5a data.<br><br>These are meta data files for use with "Scripts required for generating sulphate ancillary files". The contents are two grid definitions the ECLIPSE v5 data land grid (eclipse_land_grid) and the N96_grid definition. The RCP4.5 Dimethyl Sulphide emissions which are cycled annually are also included for incorporation into the ancillary file produced.<br><br>This is code to take in ECLIPSE v5a emissions data and create ancillary files suitable for use with the MetOffice HadCM3 family of models. <br>The main code is a bash script called make_so2_nc.sh. It relies on installation of CDO, NCO and IDL (other .pro programs included here which are called from within the bash script).<br>Further metadata is require and provided in "Metadata required for generating sulphate ancillary files" part of this project.<br>
DOI: 10.6084/m9.figshare.3469199.v1
title: Sulphate Ancillary Metadata and Processing Metadata and Scripts

description: The contents of this project includes the processing scripts and required meta data to generate UM sulphate emissions ancillary files from the ECLIPSE v5a data.<br><br>These are meta data files for use with "Scripts required for generating sulphate ancillary files". The contents are two grid definitions the ECLIPSE v5 data land grid (eclipse_land_grid) and the N96_grid definition. The RCP4.5 Dimethyl Sulphide emissions which are cycled annually are also included for incorporation into the ancillary file produced.<br><br>This is code to take in ECLIPSE v5a emissions data and create ancillary files suitable for use with the MetOffice HadCM3 family of models. <br>The main code is a bash script called make_so2_nc.sh. It relies on installation of CDO, NCO and IDL (other .pro programs included here which are called from within the bash script).<br>Further metadata is require and provided in "Metadata required for generating sulphate ancillary files" part of this project.<br>
DOI: 10.6084/m9.figshare.3469199.v2
title: Sulphate Ancillary Metadata and Processing Metadata and Scripts

description: The contents of this project includes the processing scripts and required meta data to generate UM sulphate emissions ancillary files from the ECLIPSE v5a data.<br><br>These are meta data files for use with "Scripts required for generating sulphate ancillary files". The contents are two grid definitions the ECLIPSE v5 data land grid (eclipse_land_grid) and the N96_grid definition. The RCP4.5 Dimethyl Sulphide emissions which are cycled annually are also included for incorporation into the ancillary file produced.<br><br>This is code to take in ECLIPSE v5a emissions data and create ancillary files suitable for use with the MetOffice HadCM3 family of models. <br>The main code is a bash script called make_so2_nc.sh. It relies on installation of CDO, NCO and IDL (other .pro programs included here which are called from within the bash script).<br>Further metadata is require and provided in "Metadata required for generating sulphate ancillary files" part of this project.<br>
DOI: 10.6084/m9.figshare.3469169
title: Scripts - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Scripts associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469169.v2
title: Scripts - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Scripts associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469166
title: Results - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Results associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469166.v2
title: Results - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Results associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469166.v1
title: Results - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Results associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469157
title: Transposon screen mappings

description: piggyBac vector integration sites in mouse embryonic stem cells. Mapped to mouse genome m38. Fields (tab separated:ChromosomeStrandPositionTotal reads mapping to this positionReads for this barcodeBarcodeInsertion site sequence (B01 only)Gene(s) overlapping insertion siteGene description<br>
DOI: 10.6084/m9.figshare.3469121
title: Data Files - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Data associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469121.v1
title: Data Files - Text Analysis of Chemistry Thesis and Dissertation Titles

description: Data associated with: Scalfani, V. F. Text Analysis of Chemistry Thesis and Dissertation Titles, Issues in Science & Technology Librarianship, submitted August 6, 2016.
DOI: 10.6084/m9.figshare.3469115
title: mappings

description: piggyBac vector integration sites in mouse embryonic stem cells. Mapped to mouse genome m38. Insertion site is in the form: [chromosome][strand:+/-][position]. The number is the number of reads mapping to that site.<br>(Duplicate of https://dx.doi.org/10.6084/m9.figshare.3469157.v1 )<br>
DOI: 10.6084/m9.figshare.3469115.v1
title: mappings

description: piggyBac vector integration sites in mouse embryonic stem cells. Mapped to mouse genome m38. Insertion site is in the form: [chromosome][strand:+/-][position]. The number is the number of reads mapping to that site.<br>(Duplicate of https://dx.doi.org/10.6084/m9.figshare.3469157.v1 )<br>
DOI: 10.6084/m9.figshare.3469112
title: Barcode counts for transposon screens

description: Barcode counts generated from Ion Torrent sequencing data. Barcode (*.bc) files containing raw per-sample read counts for each barcode are combined to form summary files for each sequencing run (sims- and west-summary.tsv). The group.r script (customised for each seqeuncing run) combines counts for barcodes that are close in terms of Levenshtein distance, since such barcodes are likely to be systematic sequencing errors. The gg_col files are the output. Barcodes from the "west" (PB3) end of the transposon are reverse complemented (*.rc) to match with the mapping data.
DOI: 10.6084/m9.figshare.3468911
title: Supplementary Material for: Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy

description: High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer internalisation in RB cells (Y79, Weri Rb1) and non-neoplastic human retinal cells (MIO-M1) were optimised. Aptamer induced dose-dependent cytotoxicity in RB cancer cells (0.25-1.5 µM). Increased expression of <i>TGFβ</i>, <i>SMAD4</i>,<i> CDH1</i>, <i>BAX</i>, <i>CASP 3</i>,<i> PARP </i>mRNA and decreased <i>SNAI1</i>,<i> Bcl2</i> mRNA levels in aptamer-treated RB cells suggests the activation of TGFβ-<i>SMAD4</i>-mediated apoptotic pathway. Synergistic effect with etoposide was observed in aptamer treated RB cells (p value ≤0.05). No significant toxicity was observed in non-neoplastic retinal cells.
DOI: 10.6084/m9.figshare.3468911.v1
title: Supplementary Material for: Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy

description: High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer internalisation in RB cells (Y79, Weri Rb1) and non-neoplastic human retinal cells (MIO-M1) were optimised. Aptamer induced dose-dependent cytotoxicity in RB cancer cells (0.25-1.5 µM). Increased expression of <i>TGFβ</i>, <i>SMAD4</i>,<i> CDH1</i>, <i>BAX</i>, <i>CASP 3</i>,<i> PARP </i>mRNA and decreased <i>SNAI1</i>,<i> Bcl2</i> mRNA levels in aptamer-treated RB cells suggests the activation of TGFβ-<i>SMAD4</i>-mediated apoptotic pathway. Synergistic effect with etoposide was observed in aptamer treated RB cells (p value ≤0.05). No significant toxicity was observed in non-neoplastic retinal cells.
DOI: 10.6084/m9.figshare.3468908
title: Supplementary Material for: Selective COX-2 Inhibition Exerts No Negative Effects on Peripheral Blood Lymphocytes in Allergic Asthmatics

description: <b><i>Background:</i></b> Selective inhibition of cyclooxygenase-2 (COX-2) reduces the production of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), which can have both pro- and anti-inflammatory effects on allergic inflammation. Moreover, in vitro PGE<sub>2</sub> has been shown to affect inflammation through the modulation of lymphocyte responses. <b><i>Methods:</i></b> Sixteen subjects with mild allergic asthma were recruited to a two-period cross-over study: one treatment period with the selective COX-2 inhibitor etoricoxib and one without. Each treatment period ended with an airway challenge with the patient's relevant allergen. Antigen-specific proliferation with the major cat allergen, Fel d 1, was analysed in PBMCs. CD4+ T cells were phenotyped using flow cytometry, and mRNA expression of FOXP3 in anti-CD3-stimulated CD4+ cells were analysed. <b><i>Results:</i></b> No significant impact of in vivo inhibition of COX-2 was detected on the proportion of Th1, Th2, or Treg cells in peripheral blood. Likewise, the treatment had minor effects on the stimulated expression of FOXP3 mRNA in CD4+ T cells. Proliferation of PBMCs to the major cat allergen Fel d 1 was slightly reduced by etoricoxib treatment in cat-allergic patients. <b><i>Conclusions:</i></b> Short-term treatment with the COX-2 inhibitor etoricoxib had a minor impact on T-cell responses, supporting its safe use also in subjects exposed to triggers of lymphocyte activation.
DOI: 10.6084/m9.figshare.3468902
title: Supplementary Material for: Increment of HFABP Level in Coronary Artery In-Stent Restenosis Segments in Diabetic and Nondiabetic Minipigs: HFABP Overexpression Promotes Multiple Pathway-Related Inflammation, Growth and Migration in Human Vascular Smooth Muscle Cells

description: <b><i>Background:</i></b> Our previous study suggested that heart-type fatty acid-binding protein (HFABP) levels were greatly elevated in the conditioned medium of explant culture of in-stent restenosis (ISR) tissue from diabetic minipigs compared with those of non-ISR tissue. We here verified this result in animal tissues and investigated the impact of HFABP overexpression in human aortic smooth muscle cells (hASMCs). <b><i>Methods and Results:</i></b> In Western blot and real-time RT-PCR, HFABP protein and mRNA levels were significantly higher in ISR than in non-ISR tissues from minipigs, and higher in the ISR tissue from diabetic minipigs than that from nondiabetic minipigs. The mRNA microarray and cellular effects of hASMC retroviral overexpression of HFABP and vector was analyzed.<b> </b>Compared with vector, HFABP transduction activates multiple signaling pathways (e.g. adipokine, TGF-β, Toll-like receptor, Wnt, Hedgehog, ErbB and Notch) and promotes inflammation, growth and migration in hASMCs whereas the knockdown of HFABP by small hairpin RNA attenuates these effects. <b><i>Conclusion:</i></b> HFABP expression is significantly higher in ISR tissue than in non-ISR tissue from diabetic and nondiabetic minipigs. Overexpression of HFABP induces multiple pathway-related promotion of inflammation, growth and migration in vascular SMCs, suggesting a potential role in coronary artery ISR.
DOI: 10.6084/m9.figshare.3468902.v1
title: Supplementary Material for: Increment of HFABP Level in Coronary Artery In-Stent Restenosis Segments in Diabetic and Nondiabetic Minipigs: HFABP Overexpression Promotes Multiple Pathway-Related Inflammation, Growth and Migration in Human Vascular Smooth Muscle Cells

description: <b><i>Background:</i></b> Our previous study suggested that heart-type fatty acid-binding protein (HFABP) levels were greatly elevated in the conditioned medium of explant culture of in-stent restenosis (ISR) tissue from diabetic minipigs compared with those of non-ISR tissue. We here verified this result in animal tissues and investigated the impact of HFABP overexpression in human aortic smooth muscle cells (hASMCs). <b><i>Methods and Results:</i></b> In Western blot and real-time RT-PCR, HFABP protein and mRNA levels were significantly higher in ISR than in non-ISR tissues from minipigs, and higher in the ISR tissue from diabetic minipigs than that from nondiabetic minipigs. The mRNA microarray and cellular effects of hASMC retroviral overexpression of HFABP and vector was analyzed.<b> </b>Compared with vector, HFABP transduction activates multiple signaling pathways (e.g. adipokine, TGF-β, Toll-like receptor, Wnt, Hedgehog, ErbB and Notch) and promotes inflammation, growth and migration in hASMCs whereas the knockdown of HFABP by small hairpin RNA attenuates these effects. <b><i>Conclusion:</i></b> HFABP expression is significantly higher in ISR tissue than in non-ISR tissue from diabetic and nondiabetic minipigs. Overexpression of HFABP induces multiple pathway-related promotion of inflammation, growth and migration in vascular SMCs, suggesting a potential role in coronary artery ISR.
DOI: 10.6084/m9.figshare.3468896
title: ClimateDataSet.zip

description: Climate Datase Yanglin(Shaanxi province, China) from 2012 to 2015
DOI: 10.6084/m9.figshare.3468896.v1
title: ClimateDataSet.zip

description: Climate Datase Yanglin(Shaanxi province, China) from 2012 to 2015
DOI: 10.6084/m9.figshare.3468890
title: Early Career Research Network (Univ. Exeter) - Strategically Using Social Media to Communicate Science

description: This is the presentation I gave for the University of Exeter's Early Career Research Network on 30 June 2016.