cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14043509
title: Adult lifetime cost of hemophilia B management in the US: payer and societal perspectives from a decision analytic model

description: Hemophilia B (HB) is a rare congenital disorder characterized by bleeding-related complications which are managed by prophylactic or post-bleeding event (“on-demand”) replacement of clotting factor IX (FIX). The standard of care for severe HB is life-long prophylaxis with standard half-life (SHL) or extended half-life (EHL) products given every 2–3 or 7–14 days, respectively. FIX treatment costs in the US have been investigated, but the lifetime costs of HB treatment have not been well characterized, particularly related to the impact of joint health deterioration and associated health resource utilization. We developed a decision-analytic model to explore outcomes, costs and underlying cost drivers associated with FIX treatment options over the lifetime of an adult with severe or moderately severe HB. With participation from clinicians, health technology assessment specialists and patient advocates, a Markov model was constructed to estimate bleeding events and costs associated with health states including “bleed into joint”, “bleed not into joint”, “no bleed” and “death”. Sub-models of joint health were based on 0, 1, or ≥2 areas of chronic joint damage. US third-party payer and societal perspectives were considered with a lifetime horizon; sensitivity analyses tested the robustness of primary findings. Total adult lifetime costs per patient with severe and moderately severe HB were $21,086,607 for SHL FIX prophylaxis, $22,987,483 for EHL FIX prophylaxis, and $20,971,826 for on-demand FIX treatment. For FIX prophylaxis, the cost of FIX treatment accounts for &gt;90% of the total HB treatment costs. This decision analytic model demonstrated significant economic burden associated with the current HB treatment paradigm.
DOI: 10.6084/m9.figshare.14043509.v2
title: Adult lifetime cost of hemophilia B management in the US: payer and societal perspectives from a decision analytic model

description: Hemophilia B (HB) is a rare congenital disorder characterized by bleeding-related complications which are managed by prophylactic or post-bleeding event (“on-demand”) replacement of clotting factor IX (FIX). The standard of care for severe HB is life-long prophylaxis with standard half-life (SHL) or extended half-life (EHL) products given every 2–3 or 7–14 days, respectively. FIX treatment costs in the US have been investigated, but the lifetime costs of HB treatment have not been well characterized, particularly related to the impact of joint health deterioration and associated health resource utilization. We developed a decision-analytic model to explore outcomes, costs and underlying cost drivers associated with FIX treatment options over the lifetime of an adult with severe or moderately severe HB. With participation from clinicians, health technology assessment specialists and patient advocates, a Markov model was constructed to estimate bleeding events and costs associated with health states including “bleed into joint”, “bleed not into joint”, “no bleed” and “death”. Sub-models of joint health were based on 0, 1, or ≥2 areas of chronic joint damage. US third-party payer and societal perspectives were considered with a lifetime horizon; sensitivity analyses tested the robustness of primary findings. Total adult lifetime costs per patient with severe and moderately severe HB were $21,086,607 for SHL FIX prophylaxis, $22,987,483 for EHL FIX prophylaxis, and $20,971,826 for on-demand FIX treatment. For FIX prophylaxis, the cost of FIX treatment accounts for &gt;90% of the total HB treatment costs. This decision analytic model demonstrated significant economic burden associated with the current HB treatment paradigm.
DOI: 10.6084/m9.figshare.14043509.v1
title: Adult lifetime cost of hemophilia B management in the US: Payer and societal perspectives from a decision analytic model

description: Hemophilia B (HB) is a rare congenital disorder characterized by bleeding-related complications which are managed by prophylactic or post-bleeding event (“on-demand”) replacement of clotting factor IX (FIX). The standard of care for severe HB is life-long prophylaxis with standard half-life (SHL) or extended half-life (EHL) products given every 2-3 or 7-14 days, respectively. FIX treatment costs in the US have been investigated, but the lifetime costs of HB treatment have not been well characterized, particularly related to the impact of joint health deterioration and associated health resource utilization. We developed a decision-analytic model to explore outcomes, costs and underlying cost drivers associated with FIX treatment options over the lifetime of an adult with severe or moderately severe HB. With participation from clinicians, health technology assessment specialists and patient advocates, a Markov model was constructed to estimate bleeding events and costs associated with health states including ‘bleed into joint’, ‘bleed not into joint’, ‘no bleed’ and death. Sub-models of joint health were based on 0, 1, or ≥2 areas of chronic joint damage. US third-party payer and societal perspectives were considered with a lifetime horizon; sensitivity analyses tested the robustness of primary findings. Total adult lifetime costs per patient with severe and moderately severe HB were $21,086,607 for SHL FIX prophylaxis, $22,987,483 for EHL FIX prophylaxis, and $20,971,826 for on-demand FIX treatment. For FIX prophylaxis, the cost of FIX treatment account for &gt;90% of the total HB treatment costs. This decision analytic model demonstrated significant economic burden associated with the current HB treatment paradigm.
DOI: 10.25919/se8f-2s59
title: Parkes observations for project P960 semester 2021APRS_01

description: We aim to carry out receiver pointing and characterisation tests of Parkes receivers. Typically, these tests are carried out after the receiver package is installed, but time does not always allow for proper characterisation. Receivers for consideration include UWL, MARS, SX, K/KU-BAND and 13MM packages. In addition to cross-referencing C007 for flux calibration via pointing, we aim to conduct gain-elevation and system temperature experiments using the Moon, to ensure users of the Parkes Observatory have the most accurate information available for calibration purposes. We also wish to fully characterise the spectro-polarimetry response of the UWL, by determining the Mueller Matrix of the receiver.
DOI: 10.6084/m9.figshare.14546169
title: background_WTPT.csv

description: Background data white-tailed ptarmigan
DOI: 10.6084/m9.figshare.14546169.v1
title: background_WTPT.csv

description: Background data white-tailed ptarmigan
DOI: 10.6084/m9.figshare.14546166
title: background_WIPT.csv

description: Background data willow ptarmigan
DOI: 10.6084/m9.figshare.14546166.v1
title: background_WIPT.csv

description: Background data willow ptarmigan
DOI: 10.6084/m9.figshare.14546157.v1
title: background_ROPT.csv

description: Background data for rock ptarmigan
DOI: 10.6084/m9.figshare.14546157
title: background_ROPT.csv

description: Background data for rock ptarmigan
DOI: 10.6084/m9.figshare.14546196.v1
title: White-tailed ptarmigan occurence data

description: White-tailed ptarmigan occurence data
DOI: 10.6084/m9.figshare.14546196
title: White-tailed ptarmigan occurence data

description: White-tailed ptarmigan occurence data
DOI: 10.26036/cnp0001393
title: yongzhaozhou-1

description: 数据用于做科研
DOI: 10.26036/cnp0001820
title: Knockdown of miR-22a in zebrafish

description: Knockdown of miR-22a in zebrafish embro
DOI: 10.6084/m9.figshare.14546184.v1
title: Willow ptarmigan occurence data

description: Willow ptarmigan occurence data
DOI: 10.6084/m9.figshare.14546184
title: Willow ptarmigan occurence data

description: Willow ptarmigan occurence data
DOI: 10.6084/m9.figshare.14546178
title: Rock ptarmigan occurence data

description: Rock ptarmigan occurence data
DOI: 10.6084/m9.figshare.14546178.v1
title: Rock ptarmigan occurence data

description: Rock ptarmigan occurence data
DOI: 10.6084/m9.figshare.14546205
title: Protected areas

description: Downloaded from https://www.protectedplanet.net/en
DOI: 10.6084/m9.figshare.14546205.v1
title: Protected areas

description: Downloaded from https://www.protectedplanet.net/en
DOI: 10.6084/m9.figshare.14546262
title: Current and future climate and habitat stacks

description: - s.all includes stacks of current scenarios (climate and habitat) - ACCESS, CESM1, MIRO are future climatic stacks- Future BEC are future scenarios of BEC zone habitats
DOI: 10.5517/ccdc.csd.cc2486xk
title: CCDC 1974108: Experimental Crystal Structure Determination

description: Related Article: Hongkai Wang, Tianlong Zeng, Weixing Chang, Lingyan Liu, Jing Li|2021|Org.Lett.|23|3573|doi:10.1021/acs.orglett.1c00976
DOI: 10.5517/ccdc.csd.cc26wpvn
title: CCDC 2052412: Experimental Crystal Structure Determination

description: Related Article: Li Tan, Zhishan Luo, Xiaoyong Chang, Yi Wei, Min Tang, Wen Chen, Qian Li, Pengfei Shen, Zewei Quan|2021|Inorg.Chem.|60|6600|doi:10.1021/acs.inorgchem.1c00393
DOI: 10.5517/ccdc.csd.cc26vn2t
title: CCDC 2051396: Experimental Crystal Structure Determination

description: Related Article: Sudarshan Debnath, Lingli Liang, Mei Lu, Yian Shi|2021|Org.Lett.|23|3237|doi:10.1021/acs.orglett.1c00466
DOI: 10.5517/ccdc.csd.cc270gwm
title: CCDC 2056040: Experimental Crystal Structure Determination

description: Related Article: Marion Till, John A. Kelly, Christoph G. P. Ziegler, Robert Wolf, Tianao Guo, Mark R. Ringenberg, Eugen Lutsker, Oliver Reiser|2021|Organometallics|40|1042|doi:10.1021/acs.organomet.1c00042
DOI: 10.5517/ccdc.csd.cc270gxn
title: CCDC 2056041: Experimental Crystal Structure Determination

description: Related Article: Marion Till, John A. Kelly, Christoph G. P. Ziegler, Robert Wolf, Tianao Guo, Mark R. Ringenberg, Eugen Lutsker, Oliver Reiser|2021|Organometallics|40|1042|doi:10.1021/acs.organomet.1c00042
DOI: 10.6084/m9.figshare.14559471
title: Electrochemical application of zirconium-based metal-organic framework

description: This work highlights the electrochemical applications of Zirconium metal-organic framework (Zr-MOF). As-synthesized material was characterized by the techniques such as SEM, Single crystal XRD, TGA, and BET. The electrochemical energy storage property of prepared Zr-MOF electrode was investigated in 0.1 M KOH. The cyclic voltammogram studies were carried out to find the electrochemical behavior of Zr-MOF electrode. The clearly separated oxidation and reduction peak implied the battery behavior of Zr-MOF electrode. The constant-current charge/discharge curves with obvious plateaus achieved by Zr-MOF electrode is due to battery act of the material. The Zr-MOF electrode has shown long term stability with higher specific capacity about 1043.2 mAhg<sup>−1</sup> in KOH. The Nyquist plot (EIS) study confirms the low solution resistance for Zr-MOF.
DOI: 10.6084/m9.figshare.14559471.v1
title: Electrochemical application of zirconium-based metal-organic framework

description: This work highlights the electrochemical applications of Zirconium metal-organic framework (Zr-MOF). As-synthesized material was characterized by the techniques such as SEM, Single crystal XRD, TGA, and BET. The electrochemical energy storage property of prepared Zr-MOF electrode was investigated in 0.1 M KOH. The cyclic voltammogram studies were carried out to find the electrochemical behavior of Zr-MOF electrode. The clearly separated oxidation and reduction peak implied the battery behavior of Zr-MOF electrode. The constant-current charge/discharge curves with obvious plateaus achieved by Zr-MOF electrode is due to battery act of the material. The Zr-MOF electrode has shown long term stability with higher specific capacity about 1043.2 mAhg<sup>−1</sup> in KOH. The Nyquist plot (EIS) study confirms the low solution resistance for Zr-MOF.
DOI: 10.6084/m9.figshare.14559480
title: R Script - Scridel et al. 2021

description: R script (Scridel et al. 2021)
DOI: 10.6084/m9.figshare.14559480.v1
title: R Script - Scridel et al. 2021

description: R script (Scridel et al. 2021)
DOI: 10.6084/m9.figshare.14546262.v1
title: Current and future climate and habitat stacks

description: - s.all includes stacks of current scenarios (climate and habitat) - ACCESS, CESM1, MIRO are future climatic stacks- Future BEC are future scenarios of BEC zone habitats
DOI: 10.6084/m9.figshare.14559486
title: Data_BJGC

description: Age, gender, DUBS, MBI
DOI: 10.6084/m9.figshare.14559486.v1
title: Data_BJGC

description: Age, gender, DUBS, MBI
DOI: 10.26036/cnp0000689
title: Gonadal Transcriptome during Sex Determination and Differentiation in Cynoglossus semilaevis

description: In order to study the relationship between sex-determination and environmental temperature, transcriptomes of undifferentiated gonads from genetic females and males, as well as differentiated gonads from males, females, and pseudomales under high and normal temperature treatments were generated for comparative transcriptomic analysis.
DOI: 10.26036/cnp0000900
title: Molecular regulation of culm shape in Dendrocaramus sinicus

description: A total of 33 samples from two Dendrocaramus sinicus culm types at four developmental stages were sequenced using a BGISEQ-500 sequencer. Transcriptomes were assembled using Trinity de novo assembly followed by annotation. In total, 339,221 unigenes with a mean length of 2,001 bp and N50 length of 2,825 bp were obtained, and 244,534 (72.1%) unigenes were successfully annotated. Then, 94,692 simple sequence repeats (SSRs) were identified in 72,609 unigenes, and 10,236 transcription factors were predicted.
DOI: 10.26036/cnp0000467
title: Angiostrongylus cantonensis Genome sequencing and assembly

description: Angiostrongylus cantonensis is the most common parasitic cause of eosinophilic meningitis. Adult A. cantonensis live in the pulmonary arteries of rats. The females lay eggs that hatch, yielding first­stage larvae, in the terminal branches of the pulmonary arteries. The first­stage larvae migrate to the pharynx, are swallowed, and pass in the feces. They penetrate, or are ingested by, an intermediate host (snail or slug). After two molts, third­stage larvae are produced, which are infective to mammalian hosts. When the mollusk is ingested by the definitive host, the third­stage larvae migrate to the brain where they develop into IV and V stage larvae. The V stage larvae return to the venous system and then to the pulmonary arteries, where they become sexually mature. Humans can acquire the infection by eating raw or undercooked snails or slugs infected with the parasite.Here, we sequenced the genome and transcriptome across different development stages to investigate potential genetic basis of its complex life-cycle.
DOI: 10.26036/cnp0000815
title: 鹅掌楸基因组组装

description: 鹅掌楸基因组及注释结果染色体版
DOI: 10.26036/cnp0000067
title: Maternal cancer research (Phase II)

description: Several studies have associated multiple chromosomal aneuploidies (MCAs) detected in NIPTs with maternal malignancy. After the first case described by Osborn et al in 2013, several subsequent studies have described maternal cancer within failed NIPT tests due to MCAs. In 2015, Bianchi discovered 10 maternal cancer cases from 125,426 pregnancies based on aneuploidies involving chromosomes 13, 18, 21, X, or Y in NIPT tests; eight of the 10 cases showed nonspecific copy-number gains and losses across multiple chromosomes. In 2017, Dharajiya detected 18 maternal malignancies in 43 failed NIPT cases with altered genomic profiles. These studies suggest that MCAs in NIPTs may indicate occult maternal malignancy, yet the sensitivity and specificity of MCAs alone are far too low to be useful in clinical practice.To the best of our knowledge, this is the largest study about the association between MCAs and maternal malignancy. We developed a method for combining MCA findings with whole-genome profiling of copy number variations, and the method in combination with serum tumor markers showed good diagnostic performance in the detection of pre-symptomatic maternal cancer.This study provides evidence that MCAs results can be finely translated into clinical use for identifying maternal malignancy. Maternal malignancy can be detected with significantly higher sensitivity and PPV using the methods than using MCAs alone. The additional use of serum tumour markers allows determination of the primary tumour origin, which can help guide further clinical evaluation of suspected cancer cases.
DOI: 10.26036/cnp0000344
title: 巨魾全基因组WGS

description: 基于NGS和PacBio测序，组装硬骨鱼巨魾（Bagarius yarrelli）全基因组
DOI: 10.26036/cnp0000388
title: chimera-competent of XEN cells from pig blastocysts

description: Here we report the derivation and characterization of extraembryonic endoderm (XEN) stem cells from porcine (p) embryos. The pXEN cells can be reliably and reproducibly derived from primitive endoderm precursors in primary cultures of pig blastocyst-stage embryos. When injected into blastocyst-stage embryos, the pXEN cells have contributed to wide-spread chimerism including visceral yolk sac, chorion of the extraembryonic membranes, as well as definitive endoderm of the fetus, primarily the embryonic gut and liver primordium. Additionally, these XEN cells have proven to be an efficient nuclear donor for generating cloned offspring. These newly discovered stem cells provide a novel model for studying lineage segregation, as well as a source for interspecies chimeras for generating endodermal organs, and for genome editing in livestock.
DOI: 10.26036/cnp0000046
title: Cotton genome sequencing project

description: Cotton is economically the most important natural fiber producing crop in the world. After polyploidization, Gossypium hirsutum evolved to produce a higher fiber yield and to survive better in harsh environments than G. barbadense which produces longer, and hence superior quality fibers. Here, we provide the data of TM-1 (Gossypium hirsutum) and Hai7124 (G. barbadense) that used for genome assembly. The data includes 2 PE libraries，3 MP libraries and a 10X Gemcode library that sequenced by Illumina platform. In addition, we also provided sequencing data from 4 upland cottons and 8 sealand cottons.
DOI: 10.26036/cnp0000428
title: Single Cell Dissection of the Multicellular Ecosystem of Nasopharyngeal Carcinoma

description: Here, we applied single-cell RNA sequencing to comprehensively evaluate the multicellular ecosystem of 15 primary NPC tumors. This study represents an important step toward understanding the cellular ecosystem in the TME of NPC and identifies novel prognostic signatures and potential targets, which helps guide future precision-treatment strategies.
DOI: 10.26036/cnp0000035
title: De novo genome assembly of the yellow rattan(Daemonorops jenkinsiana)

description: we report hybrid de novo genome assembly and gene annotation of the D. jenkinsiana (the second genome sequenced in rattan), which will facilitate molecular breeding and genome-assisted cultivar breeding as well as comparative genome analysis.
DOI: 10.26036/cnp0000066
title: single-tube LFR

description: single tube long fragment read (stLFR) technology enables efficient WGS, haplotyping, and contig scaffolding. It is based on adding the same barcode sequence to sub-fragments of the original DNA molecule (DNA co-barcoding). To achieve this, stLFR uses the surface of microbeads to create millions of miniaturized compartments in a single tube. Using a combinatorial process over 1.8 billion unique barcode sequences were generated on beads, enabling practically non-redundant co-barcoding in reactions with 50 million barcodes. Using stLFR we demonstrate efficient unique co-barcoding of over 8 million 20-300 kb genomic DNA fragments with near perfect variant calling and phasing of the genome of NA12878 into contigs up to N50 23.4 Mb. stLFR represents a low-cost single library solution that can enable long sequence data.
DOI: 10.26036/cnp0000075
title: Multi-platform single cell transcriptomic profiling

description: We generated those datasets to provide a publicly available resource for scRNA-seq, hoping that this resource serves as a starting point to systematically compare and benchmark different sequencing protocols. Two popular model cell lines were selected as starting materials, considering that there are also other types of datasets generated under different experimental perturbations.
DOI: 10.6084/m9.figshare.14559510
title: Data source_FLIB

description: Data source_FLIB
DOI: 10.26036/cnp0001229
title: Analysis of Scale Metagenomes of Manis Javanica

description: Sequencing of three scale metagenomes of Malayan pangolin (Manis javanica).
DOI: 10.26036/cnp0000090
title: Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

description: Umbilical cord blood (UCB) transplant is a therapeutic option for both pediatric and adult patients with a variety of hematologic diseases such as several types of blood cancers, myeloproliferative disorders, genetic diseases, and metabolic disorders. However, the level of cellular heterogeneity and diversity of nucleated cells in the UCB has not yet been assessed in an unbiased and systemic fashion. In the current study, nucleated cells from UCB were subjected to single-cell RNA sequencing, a technology enabled simultaneous profiling of the gene expression signatures of thousands of cells, generating rich resources for further functional studies. Here, we report the transcriptome of 17,637 UCB cells, covering twelve major cell types. Many of these cell types are comprised of distinct subpopulations. Pseudotemporal ordering of nucleated red blood cells (NRBC) identifies wave-like activation and suppression of transcription regulators, leading to a polarized cellular state, which may reflect NRBC maturation. Progenitor cells in UCB also consist two subpopulations with divergent transcription programs activated, leading to specific cell-fate commitment. Detailed profiling of cytotoxic cell populations unveiled granzymes B and K signatures in NK and NKT cell types in UCB. Collectively, we provide this comprehensive single-cell transcriptomic landscape and show that it can uncover previously unrecognized cell types, pathways and gene expression regulations that may contribute to the efficacy and outcome of UCB transplant, broadening the scope of research and clinical innovations.
DOI: 10.26036/cnp0000756
title: Phytophthora cactorum genome

description: The Phytophthora cactorum strain was sequenced using PacBio single-molecule sequencing, which isolated from Panax notoginseng in Yunnan, China.
DOI: 10.26036/cnp0000823
title: Genome-wide CRISPR screen in Diffuse Large B-cell Lymphoma

description: Genome-wide CRISPR screen in Diffuse Large B-cell Lymphoma
DOI: 10.26036/cnp0001061
title: Macrocystis pyrifera transcriptome

description: Gene‐Regulated Responses to the oxylipin messenger of 1-Octen-3-ol in Mycrocystis pyrifera