cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.15671855
title: snFLARE-seq and mrFRIGID for the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins

description: Prostate cancer cells of different anatomical locations display remarkable heterogeneity. This poses a challenge to the clinical relevance of pre-clinical models and the efficacy of contemporary therapeutic approaches. Here we developed the snFLARE-seq and mrFRIGID methodologies to directly investigate the transcriptomic and metabolomic landscape of prostate cancer patients utilizing formalin-fixed paraffin-embedded (FFPE) specimens. A retrospective analysis revealed the clinical disparities of prostate cancer from peripheral zone (PZ), transition zone (TZ), and across PZ and TZ. The snFLARE-seq, refined for enhanced single-nucleus sequencing, unveiled distinct cell type distributions and signaling pathways between PZ and TZ samples. Hormone therapy substantially affected cancer cells and microenvironment, leading to a polarized feature of epithelial cells and a subverted immune microenvironment. With improvements on metabolite extraction, mrFRIGID revealed unique metabolic features of prostate cancer from different origins. The metabolomic results indicate that PZ cancer cells were in a metabolic-dormant status, which were probably awaken by hormone therapy. Integrative analysis of results from snFLARE-seq, mrFRIGID, and TCGA database uncovered four metabolic pathways and related genes associated with disease aggressiveness. Our work would accelerate investigations on disease heterogeneity and evolution in real-world clinical settings, stimulating patient-specific precision healthcare solutions.
DOI: 10.5281/zenodo.15671856
title: snFLARE-seq and mrFRIGID for the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins

description: Prostate cancer cells of different anatomical locations display remarkable heterogeneity. This poses a challenge to the clinical relevance of pre-clinical models and the efficacy of contemporary therapeutic approaches. Here we developed the snFLARE-seq and mrFRIGID methodologies to directly investigate the transcriptomic and metabolomic landscape of prostate cancer patients utilizing formalin-fixed paraffin-embedded (FFPE) specimens. A retrospective analysis revealed the clinical disparities of prostate cancer from peripheral zone (PZ), transition zone (TZ), and across PZ and TZ. The snFLARE-seq, refined for enhanced single-nucleus sequencing, unveiled distinct cell type distributions and signaling pathways between PZ and TZ samples. Hormone therapy substantially affected cancer cells and microenvironment, leading to a polarized feature of epithelial cells and a subverted immune microenvironment. With improvements on metabolite extraction, mrFRIGID revealed unique metabolic features of prostate cancer from different origins. The metabolomic results indicate that PZ cancer cells were in a metabolic-dormant status, which were probably awaken by hormone therapy. Integrative analysis of results from snFLARE-seq, mrFRIGID, and TCGA database uncovered four metabolic pathways and related genes associated with disease aggressiveness. Our work would accelerate investigations on disease heterogeneity and evolution in real-world clinical settings, stimulating patient-specific precision healthcare solutions.
DOI: 10.15468/dl.tvnc6p
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, India, Myanmar, Nepal, Bhutan, Bangladesh, Pakistan, Afghanistan)",
 "TaxonKey is Prosotas pia Toxopeus, 1929"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048551-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sc4jbq
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Norway",
 "Locality is Borge Kapell, Fredrikstad, Øs",
 "Month is November",
 "Year 2020-2020"
 ]
}

 The dataset includes 8 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048553-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c2u7ku
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, India, Myanmar, Nepal, Bhutan, Bangladesh, Pakistan, Afghanistan)",
 "TaxonKey is Prosotas bhutea"
 ]
}

 The dataset includes 4 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048555-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7910/dvn/vfv3mi
title: Příloha č. 3 – Navazující rozhodnutí a odpovědi obecných soudů

description: Příloha č. 3 – Navazující rozhodnutí a odpovědi obecných soudů
DOI: 10.5281/zenodo.15671726
title: Remote Sensing image patches at debris flow locations, globally and in Sichuan, China.
DOI: 10.5281/zenodo.15671725
title: Remote Sensing image patches at debris flow locations, globally and in Sichuan, China.
DOI: 10.34740/kaggle/dsv/12180279
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.17045/sthlmuni.22555663
title: Supplementary Fig. 3d | Motor neurons markers in homogeneous differentiation protocol

description: This item is part of the <b>Figshare Project</b>:<br><b>Early mitochondrial dysfunction revealed across FUS- and TARDBP-ALS at single cell resolution</b><br>From <i>Data Availability Statement</i> for the forthcoming paper in <i>Nature Communications</i> entitled:<b>Single-cell RNA sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS</b>"We have deposited all raw and processed RNA sequencing data generated in this study on the NCBI Gene Expression Omnibus (GEO) under the accession number GSE226482. The <i>C9orf72</i>-ALS bulk RNA sequencing data was retrieved directly from the authors of the study.[Items under this Figshare Project contain:] "Scans of fluorescent western blots, raw imaging files from confocal microscopy, the analysis files from Opera Phenix, qPCR data sets, and Seahorse assay result files."--------------------------------------------[Item specific description:]Confocal immunofluorescence microscopy of in-vitro differentiated ALS motor neurons for expression of motor neuron markers.Sample meta information is available as XLSX file.The file format is .czi, through the ZEN software (Zeiss). Zeiss recommends using ImageJ and the ImageJ-based Fiji software package.<br>Information about the microscopy file format CZI can be found here: https://www.zeiss.com/microscopy/en/products/software/zeiss-zen/czi-image-file-format.html<br><br>
DOI: 10.17045/sthlmuni.22555663.v1
title: Supplementary Fig. 3d | Motor neurons markers in homogeneous differentiation protocol

description: This item is part of the <b>Figshare Project</b>:<br><b>Early mitochondrial dysfunction revealed across FUS- and TARDBP-ALS at single cell resolution</b><br>From <i>Data Availability Statement</i> for the forthcoming paper in <i>Nature Communications</i> entitled:<b>Single-cell RNA sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS</b>"We have deposited all raw and processed RNA sequencing data generated in this study on the NCBI Gene Expression Omnibus (GEO) under the accession number GSE226482. The <i>C9orf72</i>-ALS bulk RNA sequencing data was retrieved directly from the authors of the study.[Items under this Figshare Project contain:] "Scans of fluorescent western blots, raw imaging files from confocal microscopy, the analysis files from Opera Phenix, qPCR data sets, and Seahorse assay result files."--------------------------------------------[Item specific description:]Confocal immunofluorescence microscopy of in-vitro differentiated ALS motor neurons for expression of motor neuron markers.Sample meta information is available as XLSX file.The file format is .czi, through the ZEN software (Zeiss). Zeiss recommends using ImageJ and the ImageJ-based Fiji software package.<br>Information about the microscopy file format CZI can be found here: https://www.zeiss.com/microscopy/en/products/software/zeiss-zen/czi-image-file-format.html<br><br>
DOI: 10.15468/dl.ybze6w
title: Occurrence Download

description: A dataset containing 8644 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Acoustic monitoring in nature travel destinations of Colombia"
 ]
}

 The dataset includes 8644 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048556-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14422713
title: The intermediate-mass black hole 2XMM J123103.2+110648: a varying disc accretion rate during possible X-ray quasi-periodic eruptions?

description: This package contains the data analysed in the paper "The intermediate-mass black hole 2XMM J123103.2+110648: a varying disc accretion rate during possible X-ray quasi-periodic eruptions?". The software XSPEC (Arnaud 1996) is needed to perform the spectral analysis and reproduce the results shown in the paper. The slim disc model "slimdz" (Wen et al. 2022) is required to reproduce the spectral analysis in the paper.

The structure is as follows:

./reproduction-J1231/jointfit.xcm: data as well as the model for reproducing the joint-fits reported in the paper, ready to be loaded into XSPEC.

./reproduction-J1231/x1&x2&x3&s1&c1: contains all data used in the paper, grouped by their observation epochs and labelled as presented in Table 1 in the paper.
DOI: 10.5281/zenodo.14422714
title: The intermediate-mass black hole 2XMM J123103.2+110648: a varying disc accretion rate during possible X-ray quasi-periodic eruptions?

description: This package contains the data analysed in the paper "The intermediate-mass black hole 2XMM J123103.2+110648: a varying disc accretion rate during possible X-ray quasi-periodic eruptions?". The software XSPEC (Arnaud 1996) is needed to perform the spectral analysis and reproduce the results shown in the paper. The slim disc model "slimdz" (Wen et al. 2022) is required to reproduce the spectral analysis in the paper.

The structure is as follows:

./reproduction-J1231/jointfit.xcm: data as well as the model for reproducing the joint-fits reported in the paper, ready to be loaded into XSPEC.

./reproduction-J1231/x1&x2&x3&s1&c1: contains all data used in the paper, grouped by their observation epochs and labelled as presented in Table 1 in the paper.
DOI: 10.15468/dl.hrc7nk
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Presence of Pterobunocephalus depressus (Haseman, 1911) (Siluriformes, Aspredinidae) in freshwaters of Argentina."
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048558-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rzv438
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Osteology and phylogenetic position of Plagiosaurus depressus (Temnospondyli: Plagiosauridae) from the Late Triassic of Germany and the repeated loss of dermal bones in plagiosaurids"
 ]
}

 The dataset includes 3 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048559-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6vhsq2
title: Occurrence Download

description: A dataset listing the 4070347 species recorded in GBIF matching the query:
{
 "License" : [
 "is one of (CC0 1.0, CC-BY 4.0, CC-BY-NC 4.0, Pending, Incompatible)"
 ]
}

 The dataset's 4070347 records were derived from 73834 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048550-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jkqt3w
title: Occurrence Download

description: A dataset containing 8644 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Acoustic monitoring in nature travel destinations of Colombia"
 ]
}

 The dataset includes 8644 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048560-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9rv4d9
title: Occurrence Download

description: A dataset containing 29 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Naturalis Biodiversity Center (NL) - Botany",
 "TaxonKey is Salsola baryosma (Roem. & Schult.) Dandy"
 ]
}

 The dataset includes 29 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048561-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xy3exk
title: Occurrence Download

description: A dataset containing 55750735 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "License is CC-BY 4.0",
 "Month is one of (January, February, March, April, May, June, July)"
 ]
}

 The dataset includes 55750735 records from 1986 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048547-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zmrahb
title: Occurrence Download

description: A dataset containing 398 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Base de datos de la colección herpetológica de la Facultad de Ciencias de la Universidad Autónoma de Baja California",
 "Geometry POLYGON((-115.77162 29.62346,-114.97192 30.31332,-115.45532 32.74772,-117.09229 32.4304,-115.77162 29.62346))",
 "HasGeospatialIssue is false",
 "TaxonKey is Reptilia"
 ]
}

 The dataset includes 398 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0327686-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jsedyy
title: Occurrence Download

description: A dataset containing 23659 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Passiflora foetida L."
 ]
}

 The dataset includes 23659 records from 463 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0176646-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.msgcuj
title: Occurrence Download

description: A dataset containing 106 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Herbario de la Universitat de les Illes Balears",
 "Geometry POLYGON((2.4726116524997432 39.52349760293937,2.4857553376656036 39.52349760293937,2.4857553376656036 39.53664128810523,2.4726116524997432 39.53664128810523,2.4726116524997432 39.52349760293937))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 106 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002221-230918134249559/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d3keyg
title: Occurrence Download

description: A dataset containing 5050 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "Geometry POLYGON((-103.83728 18.42522,-101.94763 17.78825,-99.63501 19.98948,-102.22778 20.73107,-103.58459 19.87813,-103.83728 18.42522))",
 "HasGeospatialIssue is false",
 "TaxonKey is Cuculidae"
 ]
}

 The dataset includes 5050 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0325760-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qpvc6v
title: Occurrence Download

description: A dataset containing 899 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Chinese Taipei",
 "Country is China",
 "Country is Hong Kong",
 "Country is Macao"
 ]
 },
 "OccurrenceStatus is Present",
 "TaxonKey is Miscanthus floridulus (Labill.) Warb. ex K.Schum. & Lauterb."
 ]
}

 The dataset includes 899 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0267649-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.km3hbw
title: Occurrence Download

description: A dataset containing 9480631 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "Year 1901-2023"
 ]
}

 The dataset includes 9480631 records from 4161 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000563-230918134249559/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/hd1-9mq-gb2
title: Achnatherum calamagrostis (L.) P.Beauv.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd2-c1y-hn4
title: Juniperus communis x ssp. communis × ssp. nana

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd1-bfl-hnl
title: Thalictrum simplex L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd2-jqe-017
title: Trifolium campestre Schreb.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd2-tm9-ts4
title: Alopecurus pratensis L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd2-wre-v87
title: Persicaria minor (Huds.) Opiz

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd2-ynp-0ss
title: Trifolium aureum Pollich

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-5kc-qvd
title: Zannichellia palustris subsp. pedicellata (Rosén & Wahlenb.) Arcang.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-aby-m8q
title: Trichophorum cespitosum (L.) Hartm.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-c7c-0fd
title: Geum urbanum L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-ce6-4z1
title: Delphinium ajacis L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-evb-sb0
title: Plantae

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-k74-hdc
title: Neottia ovata (L.) Hartm.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-kxb-781
title: Zannichellia P.Micheli ex L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-n10-pvs
title: Potentilla erecta (L.) Raeusch.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-nzb-z8b
title: Potamogeton polygonifolius Pourr.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-qkv-j6f
title: Fragaria vesca L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd3-yzw-ts1
title: Rhynchospora fusca (L.) W.T.Aiton

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-53r-zdv
title: Carex dioica L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-7aw-9t3
title: Sorbus aucuparia subsp. aucuparia

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-87y-swx
title: Juncus L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-ahs-nmj
title: Selaginoides spinulosa (A. Braun ex Döll) Li Bing Zhang & X. M. Zhou

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-fsl-ay4
title: Botrychium matricariifolium (Döll) A. Braun ex Koch

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-ftr-sj0
title: Rumex hydrolapathum (Scop.) Huds.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-gcl-ab9
title: Rumex longifolius DC.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-mk9-75h
title: Salix cinerea L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-qat-09y
title: Prunus spinosa L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-reg-vcc
title: Poa compressa L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd4-sag-9t5
title: Potamogeton gramineus L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-3t9-sj8
title: Eschscholzia californica Cham.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-86f-apb
title: Potentilla L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-8xq-jka
title: Ranunculus acris L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-a3l-fpy
title: Lotus corniculatus L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.13140/rg.2.2.21555.08488
title: HV STEPS Analysis of PERS005-4S5 319 1 67 Real World Data by the Persian Curve (PC) HV STEP 07 PERSIAN QUANTILE COMPLETE
DOI: 10.3535/hd5-asz-rw4
title: Chenopodium hircinum Schrad.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-dsm-q6g
title: Dianthus deltoides L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hd5-f7j-zyt
title: Betula pendula Roth

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.