cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23051519
title: Supplementary Material for: Relapsed Waldenstrom’s Macroglobulinemia and Therapy-Related Myelodysplastic Syndrome with Complex Cytogenetics: A Treatment Dilemma

description: Waldenstrom’s macroglobulinemia (WM) is a lymphoplasmacytic lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M as defined by the World Health Organization Classification of hematological malignancies. Historically, the treatment options for WM were limited to alkylating agents and purine analogs. The introduction of immune therapy, including CD20 targeted therapy, proteasome inhibitors, and immune modulators, has provided benefit to those patients and has now become the standard of care. As WM patients become long-term survivors, treatment’s late toxicities have become more apparent. Here, we report a case of a 74-year-old female who presented to the hospital with fatigue and was diagnosed with WM. She was treated with bortezomib, doxorubicin, and bendamustine, followed by rituximab. After a remission period of 15 years, the patient had a relapse of WM, and bone marrow biopsy findings were consistent with intermediate-risk t-MDS with complex cytogenetics, presenting us with a treatment dilemma. We decided to treat WM, and the patient went into VGPR with residual lymphoma cells. Despite having dysplasia and complex cytogenetics, she did not have any cytopenia. Currently, she is under observation anticipating the progression of her MDS, given her intermediate I risk status. This case features the occurrence of t-MDS after therapy with bendamustine, cladribine, and doxorubicin. This highlights the need for closer monitoring and consideration of long-term adverse effects when treating patients with indolent lymphomas, especially WM. Late complications need to be considered, and risk versus benefit analysis needs to be carefully evaluated, especially in younger patients with WM.
DOI: 10.6084/m9.figshare.23898300
title: Supplementary Material for: Validation of administrative health data algorithms for identifying persons with Parkinson’s disease and the ten-year prevalence trend in Bologna, Italy

description: Introduction Health administrative databases are widely used for the estimation of the prevalence of Parkinson’s Disease (PD). Few in general, and none used in Italy, have been validated by testing their diagnostic accuracy. The primary objective was to validate two algorithms for the identification of persons with PD using clinical diagnosis as the reference standard on an Italian sample of people with PD. The second objective was to estimate 10-year trends in PD prevalence in the Bologna Local Health Trust from 2010 to 2019. Methods Two algorithms (index tests) applied to health administrative databases (hospital discharge, drug prescriptions, exemptions for medical costs) were validated against clinical diagnosis of PD by an expert neurologist (reference standard) in a cohort of consecutive outpatients. Sensitivity and specificity with relative 95% confidence intervals (CI) were calculated. The prevalence of PD in a specific year was estimated as the ratio between the number of subjects fulfilling any criteria of the algorithm with better diagnostic accuracy and the total population in the same year (x 1,000), stratified by age, sex and district of residence. Results The two algorithms showed high accuracy for identifying patients with PD: one with greater sensitivity 94.2% (CI 88.4 – 97.6) and the other with greater specificity 98.1% (CI 97.7 – 98.5). For the estimation of prevalence, we chose the most specific algorithm with the fewest total number of misclassified cases. We identified 3,798 people with PD as of December 31, 2019 corresponding to a prevalence of 4.3 per 1,000 inhabitants (CI 4.2 – 4.4). Prevalence was higher in males (4.7, CI 4.5 – 5.0) than females (3.8, CI 3.7 – 4.0) and increased with age. The crude prevalence over time was slightly elevated as it followed a progressive ageing of the population. When stratifying the prevalence for age groups we did not observe a trend except in the 45-64 year category where we observed an increasing trend over time. Conclusion Algorithms based on administrative data are accurate when detecting people with PD in the Italian public health system. In a large northern Italian population, increased prevalence of about 10% was observed in the decade 2010-2019 and is explained by increased life expectancy. These data may be useful in planning the allocation of health care resources for people with PD.
DOI: 10.6084/m9.figshare.23977797
title: Supplementary Material for: Liver enzymes and the risk of stroke among the general Japanese population: a prospective cohort study

description: Background: Stroke is a major cause of morbidity and mortality. Liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT), are markers of liver diseases with potential cardiovascular implications. Objective: This study aimed to investigate the prospective association between liver enzymes and stroke risk. Methods: We analyzed data from 3,379 men and 4,007 women without cardiovascular disease and registered in the Suita Study; a Japanese population-based prospective cohort study. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of stroke risk were estimated per quintiles of ALT, AST, and GGT in men and women. Results: Within a median follow-up period of 16.7 years, 438 incident stroke events were diagnosed. In men, compared to the second quintiles, the fifth (highest) quintiles of liver enzymes showed increased stroke risks: HRs (95% CIs) = 2.07 (1.35, 3.18) in ALT, 1.66 (1.10, 2.53) in AST, and 1.76 (1.11, 2.81) in GGT. The associations did not change with cerebral infarction risk: HRs (95% CIs) = 2.09 (1.24, 3.50) in ALT, 1.84 (1.11, 3.06) in AST, and 1.74 (1.00, 3.04) in GGT, respectively. The lowest ALT, AST, and GGT quintiles tended to show increased stroke and cerebral infarction risks, yet these associations were statistically insignificant. No such associations were shown in women. Conclusion: Elevated ALT, AST, and GGT levels were associated with increased stroke and cerebral infarction risks among Japanese men.
DOI: 10.6084/m9.figshare.24015048
title: Supplementary Material for: Utility of RNA Expression to Determine the Tissue of Origin of Malignancies with an Inconclusive Histopathology

description: We present two cases of cancer of unknown origin in which RNA-based cancer classification testing provided vital insight and directed treatment management. The tissue of origin could not be determined in both these patients utilizing morphology and immunohistochemical (IHC) analysis of the tissue samples. Next-generation sequencing (NGS) and tumor-of-origin testing using an RNA-based molecular cancer classifier were performed to elucidate the possible tissue of origin. A 61-year-old male with a history of localized basal cell carcinoma (BCC) presented with a 4.4 cm axillary lymph node in addition to upper extremity edema and supraclavicular lymphadenopathy. RNA based tumor origin testing revealed skin basal or squamous cell carcinoma as the likely tissue of origin, with a probability of 97%. He received vismodegib, a hedgehog inhibitor, after progression on cemiplimab and experienced a partial response by RECIST criteria, which is currently ongoing for over a year. A 74-year-old female patient with a remote history of ovarian cancer for which she underwent resection and adjuvant chemotherapy presented 15 years later with abdominal pain. The diagnostic workup revealed a 2 cm pancreatic mass and enlarged peritoneal lymph nodes. RNA sequencing revealed a 99% likelihood of the tissue of origin being serous ovarian carcinoma. Subsequently, she underwent surgery and adjuvant chemotherapy and is currently in remission with letrozole maintenance. Genomic data already plays a crucial role in therapeutic decision-making for individuals with cancer. These cases highlight the complementary role of genomic data in the diagnostic workup of cancer, leading to favourable patient outcomes.
DOI: 10.6084/m9.figshare.24174627
title: Supplementary Material for: Endoscopic extraction of two giant stone bezoars using mechanical and laser lithotripsy.

description: Not required
DOI: 10.6084/m9.figshare.24186408
title: Supplementary Material for: Favorable Impact of Serum TERT C228T for Prognosis after Surgical Resection for Liver Cancer

description: <b><i>Introduction:</i></b> Personalized medicine and molecular therapies with the diagnosis of somatic genetic alterations are expected to be developed for liver cancer. Nevertheless, it is unknown whether a mutation in the telomere reverse transcriptase promoter (TERT C228T) in serum cfDNA might be useful for making prognostic predictions after surgical resection for primary liver cancer. <b><i>Methods:</i></b> This cohort study retrospectively investigated 111 patients who had undergone surgical resection of liver cancer for the first time. We investigated the differences between clinicopathological features and prognosis according to classification of three tumor markers, including AFP, PIVKAII, and TERT C228T. <b><i>Results:</i></b> Multivariate analysis identified etiology (fatty liver disease vs. HBV odds ratio [OR] 6.853) and fibrosis stage (2–4, OR: 0.137) as determinants of TERT C228T-positive liver cancer with normal levels of AFP and PIVKAII (TERT single positive liver cancer). TERT single positive (Yes, OR: 0.301), fibrosis (FIB)-4 index (≥3.25, OR: 2.038), Child-Pugh classification (B, OR: 4.975), and number of tumors (≥2, OR: 4.098) were identified as determinants of the recurrence of liver cancer. TERT single positive (Yes, OR: 3.311), FIB-4 index (≥3.25, OR: 0.433), and number of tumors (≥2, OR: 0.262) were identified as determinants of disease-free survival. <b><i>Conclusions:</i></b> Our results highlight the impact of classification of prognostic tumor markers. TERT single positive is one predictor of favorable prognosis after surgical resection for liver cancer.
DOI: 10.13026/zx4k-te85
title: PTB-XL, a large publicly available electrocardiography dataset

description: Electrocardiography (ECG) is a key diagnostic tool to assess the cardiac
condition of a patient. Automatic ECG interpretation algorithms as diagnosis
support systems promise large reliefs for the medical personnel - only on the
basis of the number of ECGs that are routinely taken. However, the development
of such algorithms requires large training datasets and clear benchmark
procedures. In our opinion, both aspects are not covered satisfactorily by
existing freely accessible ECG datasets.

The PTB-XL ECG dataset is a large dataset of 21801 clinical 12-lead ECGs from
18869 patients of 10 second length. The raw waveform data was annotated by up
to two cardiologists, who assigned potentially multiple ECG statements to each
record. The in total 71 different ECG statements conform to the SCP-ECG
standard and cover diagnostic, form, and rhythm statements. To ensure
comparability of machine learning algorithms trained on the dataset, we
provide recommended splits into training and test sets. In combination with
the extensive annotation, this turns the dataset into a rich resource for the
training and the evaluation of automatic ECG interpretation algorithms. The
dataset is complemented by extensive metadata on demographics, infarction
characteristics, likelihoods for diagnostic ECG statements as well as
annotated signal properties.
DOI: 10.24432/c59k76
title: Bias correction of numerical prediction model temperature forecast
DOI: 10.5281/zenodo.8316126
title: (Data Set) Shielding Factors for a Fission-Powered Mars Exploration Rover

description: Data Set to Accompany Technical Paper: A. BENDOYRO et al., Shielding Factors for a Fission-Powered Mars Exploration Rover, 2023
DOI: 10.5281/zenodo.8384416
title: Microscopic defect dynamics during a brittle-to-ductile transition

description: Description of Data employed in “<em>Microscopic defect dynamics during a brittle-to-ductile transition</em>”- The data reported in Table S.1 of PNAS paper is as follows : All raw data [mechanical synchronized with ultrasonic probes ] are in .mat files. The data includes both strain, stress, P-velocityand waveforms of passive sensor in the point of strain-stress also are provided . All data are in 2ns time-resolution – AE_CAT_xxx includes all information recorded during test in Paterson rig. The data are synchronized with pulsing (active) and passive excitations based on simple off-line synchronized matching ; The index the AE_CAT_xxx table doe have a corresponding waveforms due to an AE in M_xxx UM_XXX are based on table S1 and does have full strain-stress data set. Dist_xx_yy is distance measurement calculated based on DTW algorithm between each pair of tests Feel free to request [ hoghaff@mit.edu or mpec@mit.edu] further information regarding our methods of analysis the data or obtaining the waves in Paterson rig. **Apart of the presented data in the paper , we repeated each test at least twice to be confident about our results in particular ultra-high frequency AEs and the strain-stress history. Feel free to request data independently from corresponding authors.
DOI: 10.6084/m9.figshare.22014524.v1
title: Glebe 1888 historic map

description: This is the georeferenced map of Glebe 1888 archived by City of Sydney
DOI: 10.6084/m9.figshare.22014539.v1
title: Concord 1894 historic map

description: This is the georeferenced map of Concord 1894 archived by Dictionary of Sydney
DOI: 10.6084/m9.figshare.23678082
title: Supplementary Material for: Quality of Life Measures in Aortic Stenosis Research: A Narrative Review

description: Background: Elderly patients with aortic stenosis (AS) not only have a reduced life expectancy but also a reduced quality of life (QoL). The benefits of an AS intervention may be considered a balance between a good QoL and a reasonably extended life. However, the different questionnaires being used to determine the QoL, were generally not developed for the specific situation of patients with AS and come with strengths and considerable weaknesses. The objective of this manuscript was to provide an overview of the available QoL instruments in AS research, describe their strengths and weaknesses, and to provide our assessment of the utility of the available scoring instruments for QoL measurements in AS. Summary: We identified and reviewed the following instruments that are used in AS research: Short Form Health Survey (SF-36/SF-12), EuroQol-5D (EQ-5D), the Illness Intrusiveness Rating Scale (IIRS), the HeartQoL, the Kansas City Cardiomyopathy Questionnaire (KCCQ), the Minnesota Living with Heart Failure Questionnaire (MLHF), the MacNew Questionnaire, and the Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ). Key messages: There is no standardized assessment of QoL in patients with AS. Many different questionaires are being used, but they are rarely specific for AS. There is a need for AS specific research into the QoL of patients as life prolongation may compete for an improved QoL in this elderly patient group.
DOI: 10.5281/zenodo.7599789
title: Robust Data-driven Metallicities for 120 Million Stars from Gaia XP Spectra

description: This is the dataset accompanying Andrae et al (2023), "Robust Data-driven Metallicities for 120 Million Stars from Gaia XP Spectra". Table 1 (124,060,658 rows) contains XGBoost parameters (temperature, surface gravity, and metallicity) for all stars in the sample. Table 2 (13,300,628 rows) contains Gaia DR3 parameters and XGBoost parameters for a vetted sample of RGB stars with reliable measurements. The tables are provided in FITS and CSV formats, and the full data model is described in the accompanying paper.
DOI: 10.6084/m9.figshare.23268470
title: Supplementary Material for: A Phase 3b Study for Management of Ocular Side Effects in Patients with EGFR-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin

description: Introduction: The Understanding New Interventions with GBM ThErapy (UNITE) study was designed to assess the effect of prophylaxis for ocular side effects (OSEs) in patients with glioblastoma receiving the antibody-drug conjugate (ADC) depatuxizumab mafodotin. UNITE (NCT03419403) was a phase 3b, open-label, randomized, exploratory study performed at 18 research sites in 5 countries. Methods: The study enrolled adult patients with epidermal growth factor receptor–amplified, histologically confirmed, newly diagnosed supra-tentorial glioblastoma or Grade IV gliosarcoma, and a Karnofsky Performance Status ≥70, receiving depatuxizumab mafodotin. All patients were administered depatuxizumab mafodotin during concurrent radiotherapy and temozolomide and with adjuvant temozolomide. Ninety patients were to be randomized (1:1:1) to OSE prophylactic treatments with each depatuxizumab mafodotin infusion: a) standard steroid eye drops, b) standard steroid eye drops plus vasoconstrictor eye drops and cold compress, or c) enhanced steroids plus vasoconstrictor eye drops and cold compress. A Corneal Epitheliopathy Adverse Event (CEAE) scale was devised to capture symptoms, grade OSEs (scale of 0–5), and inform ADC dose modifications. The primary endpoint was the frequency of a required change in OSE management due to inadequate control of OSEs, defined as decline from baseline in visual acuity (using logarithm of the minimum angle of resolution [LogMAR] scale) or a Grade ≥3 CEAE event, in the worst eye in the first 8 weeks of treatment; unless otherwise specified, the treatment period refers to both the chemoradiation and adjuvant phases. Results: The UNITE study was stopped early after interim analysis of separate phase III trial showed no difference in survival from depatuxizumab mafodotin. Forty patients were randomized (38 received depatuxizumab mafodotin). Overall, 23 patients experienced inadequate control of OSEs that required change in OSE management within 8 weeks of treatment, with 21 (70.0%) experiencing ≥+0.3 change on LogMAR scale in baseline-adjusted visual acuity and 12 reporting a Grade ≥3 CEAE. There were no definitive differences among prophylactic treatments. Conclusions: The premature cessation of the study precludes definitive conclusions regarding the OSE prophylaxis strategies. No new clinically significant safety findings were noted. Despite these limitations, this study highlights the need for novel assessment tools to better understand and mitigate OSEs associated with ADCs.
DOI: 10.25582/data.2020-03.1967514/2071489
title: Data for EMSL Project 51127 from March 2020
DOI: 10.6084/m9.figshare.23988630
title: Supplementary Material for: MRI USING GADOXETIC ACID IN THE WORK-UP OF LIVER NODULES NOT CONCLUSIVELY BENIGN IN BUDD-CHIARI SYNDROME. A PROSPECTIVE LONG-TERM FOLLOW-UP

description: Introduction The incidence of hepatocellular carcinoma (HCC) in Budd-Chiari syndrome (BCS) is unknown and there is no validated diagnostic work-up to define the liver nodules with arterial phase hyperenhancement (APHE) suggesting malignancy. This prospective study evaluates HCC incidence in a Western cohort of patients with BCS and assesses the performance of MRI with hepatobiliary contrast (HB-MRI) for nodule characterization. Methods Patients with BCS followed in our hospital were prospectively evaluated by MRI with extracellular contrast (EC-MRI). Nodules with APHE categorized as non-conclusively benign by 2 radiologists, were studied by HB-MRI and reviewed by 2 radiologists blinded to the EC-MRI results. A new EC-MRI one year later and clinical, analytical and sonographic follow-up every six months for a median of 10 years were performed. Results A total of 55 non-conclusively benign nodules with APHE were detected at EC-MRI in 41 patients. While 32 of them were suggestive of HCC by EC-MRI, all the 55 nodules showed increased uptake of hepatobiliary contrast. An unequivocal central scar was seen in 12/55 nodules at HB-MRI regardless of it was not detected on the EC-MRI. None of the nodules was hypointense in the hepatobiliary phase. HCC was not detected during a median of 10 years of follow-up. Conclusions Detection of nodules with APHE is frequent in patients with BCS, but HCC is rare in Western patients with BCS. While EC-MRI may detect nodules suggesting malignancy, the identification of contrast uptake in the hepatobiliary phase at HB-MRI may help to categorize them as benign.
DOI: 10.6073/pasta/7cdf3d7a234963b265f09b7d6d08f357
title: Time series of total and soluble iron and manganese concentrations from Falling Creek Reservoir and Beaverdam Reservoir in southwestern Virginia, USA from 2014 through 2021

description: Depth profiles of total and soluble iron and manganese were sampled from 2014-2021 in two drinking-water reservoirs, Falling Creek Reservoir (FCR) and Beaverdam Reservoir (BVR), located in Vinton, Virginia, USA. Both reservoirs are owned and operated by the Western Virginia Water Authority and are managed as secondary drinking-water sources for the city of Roanoke, VA. The dataset includes metals samples that were collected along a depth profile taken at the deepest site of the reservoir near the dam. Additional samples were collected at a gauged weir located on the primary inflow tributary, as well as at a secondary tributary, to Falling Creek Reservoir. Sampling frequency was approximately weekly during the summer and fall (May - October), approximately fortnightly during the spring (March - April), and approximately monthly during the winter (November - March).
DOI: 10.23728/fmi-b2share.3efcfc9080fe4871bd756c45373e7c11
title: Data for the manuscript "DEUCE v1.0: A neural network for probabilistic precipitation nowcasting with aleatoric and epistemic uncertainties" by Harnist et al. (2023)

description: # File descriptions: ## `verif_inputs.zip` and `verif_case_inputs.zip` Contain folders of raw PGM composites, containing needed input data for verification experiments, that is for the creation of baseline nowcast as well as observation HDF5 files. ## `deuce_inputs.zip` Contains HDF5 archives of the composite crops used for the training of DEUCE, derived from raw PGM composites using the `create_hdf5_dataset.py` script given. ## `deuce_model_checkpoints.py` Contains the two intermediate pytorch lightning checkpoints of DEUCE, as the final model checkpoint used for making predictions. ## `metrics.zip` Contains the netcdf files of verification metric values computed from DEUCE and baseline model predictions compared to observations.
DOI: 10.6084/m9.figshare.23978175
title: Supplementary Material for: Pembrolizumab induced rhabdomyolysis in a clear cell renal cell carcinoma patient: a case report

description: Pembrolizumab is one of the approved treatments for many types of cancer including clear cell renal cell carcinoma (ccRCC). It has improved the prognosis of renal cell carcinoma (RCC) yet has many possible immune related side effects. We discuss a rare case of rhabdomyolysis in an ccRCC patient treated with Pembrolizumab. The case was complicated with acute kidney injury and severe hypothyroidism, which we can be attributed to Pembrolizumab.
DOI: 10.25582/data.2020-03.1963129/2071490
title: Data for EMSL Project 51127 from March 2020