cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5772474.v1
title: Water quality evaluation of Tibagi river before the filling of Mauá HPP reservoir, using factor analysis

description: ABSTRACT Ecosystems affected by the formation of reservoirs are subjected to compulsory monitoring before, during and after the construction of the power plant. These monitoring programs generate large database that aim to satisfy environmental licensing conditions, as well as the management of water resources. In order to generate information that would facilitate the management of water resources, this study aimed to evaluate the quality of Tibagi river water located in Paraná State, Brazil, before the construction of the Mauá hydroelectric power plant (HPP). Data from four of the eight stations described in the Limnological Conditions Monitoring Program of the Tibagi river described in the HPP’s Basic Environmental Plan were analyzed. The selected data comprises the period between December 2009 and April 2012, before the HPP installation. In general, the retained factors demonstrated the anthropogenic influence on the water resources. Even with a small variation in the composition of the factor 1 in the monitored stations, this factor was especially characterized by the variables: total phosphorus, total solids, and fecal coliforms. The presence of fecal coliforms in the factor’s composition is a common indicator of pollution from untreated domestic sewage. The same applies to total phosphorus, which, as well as the total solids, can also be related to the inappropriate land use in the vicinity.
DOI: 10.6084/m9.figshare.5772471
title: Peripheral neuropathy in a copper-deficient goat

description: ABSTRACT: This report aimed to describe a case of peripheral neuropathy in a copper-deficient goat, and highlights the clinical, and pathological features of the disease. The goat had low body score, hyporexia, alopecia, achromotrichia, left hindlimb protraction, paralysis with dragging of digit and difficulty to stand up and microcytic normochromic anemia. Copper concentration in serum was markedly lower (2.0µmol L-1) whereas the iron serum content was significantly increased (51.0µmol L-1). The main gross alteration was the reduction of the quadriceps vastus laterallis muscle volume. Histologically, there was atrophy of the quadriceps vastus laterallis muscle and presence of satellite cells, infiltration of lymphocytes, macrophages and replacement of the fibers by connective tissue. In the femoral nerve, there was axonal degeneration with myelin sheath expansion and presence of vacuoles, usually in chains and containing axonal debris or macrophages. Clinical, laboratorial and pathologic findings are consistent with peripheral neuropathy due to a severy copper deficiency.
DOI: 10.6084/m9.figshare.5772471.v1
title: Peripheral neuropathy in a copper-deficient goat

description: ABSTRACT: This report aimed to describe a case of peripheral neuropathy in a copper-deficient goat, and highlights the clinical, and pathological features of the disease. The goat had low body score, hyporexia, alopecia, achromotrichia, left hindlimb protraction, paralysis with dragging of digit and difficulty to stand up and microcytic normochromic anemia. Copper concentration in serum was markedly lower (2.0µmol L-1) whereas the iron serum content was significantly increased (51.0µmol L-1). The main gross alteration was the reduction of the quadriceps vastus laterallis muscle volume. Histologically, there was atrophy of the quadriceps vastus laterallis muscle and presence of satellite cells, infiltration of lymphocytes, macrophages and replacement of the fibers by connective tissue. In the femoral nerve, there was axonal degeneration with myelin sheath expansion and presence of vacuoles, usually in chains and containing axonal debris or macrophages. Clinical, laboratorial and pathologic findings are consistent with peripheral neuropathy due to a severy copper deficiency.
DOI: 10.6084/m9.figshare.5772468
title: Employment of Aspergillus niger AN 400 in batch reactors to remove pesticide aqueous matrix

description: ABSTRACT This research proposes the use of the fungus Aspergillus niger AN 400 in treating aqueous matrix containing methyl parathion in batch reactors. The research was divided into two steps. In Step I, were mounted control reactors (RC) containing only methyl parathion in aqueous matrix; reactors with fungus (RF) containing methyl parathion and suspension of fungus spores; and reactors with fungus and ethanol (RFE) containing methyl parathion, the suspension of fungus spores and ethanol. Each reaction time (TR), one RC, one RF and one RFE were put out of operation. The reaction times were studied in 30 days. In Step II, operated a reactor with immobilized biomass (RBI) with methyl parathion and ethanol, making up 5 cycles each lasting one week. As a result, in Step I, it was found that the pH varied from 5 to 8. The final removal of 61% (RF) and 89% (RFE) of COD; 67% (RF) and 52% (RFE) of ammonia nitrogen; 34% (RF) and 45% (RFE) nitrate; 2% (RF) and 15% (RFE) of total phosphorus. In Step II, the pH ranged from 3 to 8 and the average final removal were 94% of filtered COD, 88% gross COD, 19% of ammonia nitrogen, 96% nitrate, 12% of total phosphorus and 95% of methyl parathion with immobilized biomass and 73% with disperse biomass. The results showed that the use of the fungus Aspergillus niger AN 400 can be an alternative for treating wastewater containing methyl parathion.
DOI: 10.6084/m9.figshare.5772468.v1
title: Employment of Aspergillus niger AN 400 in batch reactors to remove pesticide aqueous matrix

description: ABSTRACT This research proposes the use of the fungus Aspergillus niger AN 400 in treating aqueous matrix containing methyl parathion in batch reactors. The research was divided into two steps. In Step I, were mounted control reactors (RC) containing only methyl parathion in aqueous matrix; reactors with fungus (RF) containing methyl parathion and suspension of fungus spores; and reactors with fungus and ethanol (RFE) containing methyl parathion, the suspension of fungus spores and ethanol. Each reaction time (TR), one RC, one RF and one RFE were put out of operation. The reaction times were studied in 30 days. In Step II, operated a reactor with immobilized biomass (RBI) with methyl parathion and ethanol, making up 5 cycles each lasting one week. As a result, in Step I, it was found that the pH varied from 5 to 8. The final removal of 61% (RF) and 89% (RFE) of COD; 67% (RF) and 52% (RFE) of ammonia nitrogen; 34% (RF) and 45% (RFE) nitrate; 2% (RF) and 15% (RFE) of total phosphorus. In Step II, the pH ranged from 3 to 8 and the average final removal were 94% of filtered COD, 88% gross COD, 19% of ammonia nitrogen, 96% nitrate, 12% of total phosphorus and 95% of methyl parathion with immobilized biomass and 73% with disperse biomass. The results showed that the use of the fungus Aspergillus niger AN 400 can be an alternative for treating wastewater containing methyl parathion.
DOI: 10.6084/m9.figshare.5772465
title: Prevalence of chronic kidney disease in a population in southern Brazil (Pro-Renal Study)

description: Abstract Introduction: Chronic kidney disease (CKD) affects 10-12% of the adult population in many countries. In Brazil, there is no reliable information about the actual prevalence of CKD. Objective: To determine the prevalence of CKD by estimated glomerular filtration rate (eGFR) and proteinuria/albuminuria in an urban population randomly selected in Southern Brazil. Patients and Methods: 5,216 individuals were randomly selected out of a pool of 10,000 individuals identified from the database of a local energy company. The screening consisted of collection of demographic data, history of diabetes mellitus, hypertension, kidney/cardiovascular disease in the family and obesity through the body mass index - BMI (CKD risk factors). Blood samples were collected for determination of serum creatinine and subsequent eGFR estimation by the MDRD formula and urine samples for determination of albuminuria by dipstick. Albuminuria was further evaluated by HemoCue© in a selected CKD risk group. Results: The population was predominantly Caucasians (93%), 64% were females and the mean age of participants was 45 years old (18-87). BMI (kg/m2) was 27±5. Albuminuria was found in 5.25% of individuals. 88.6% of this population had no CKD (eGFR &gt; 60 ml/min/1.73m2 & normoalbuminuria) and 11.4% were identified as having CKD, with majority on stages 3A (7.2%) and 3B (1.1%). Hypertension, diabetes, older age and obesity was associated with a higher prevalence of CKD (p &lt; 0.001). Conclusions: The prevalence of CKD in an urban population in southern Brazil mirrors other developed countries and indicates that kidney disease is an important public health problem in Brazil.
DOI: 10.6084/m9.figshare.5772465.v1
title: Prevalence of chronic kidney disease in a population in southern Brazil (Pro-Renal Study)

description: Abstract Introduction: Chronic kidney disease (CKD) affects 10-12% of the adult population in many countries. In Brazil, there is no reliable information about the actual prevalence of CKD. Objective: To determine the prevalence of CKD by estimated glomerular filtration rate (eGFR) and proteinuria/albuminuria in an urban population randomly selected in Southern Brazil. Patients and Methods: 5,216 individuals were randomly selected out of a pool of 10,000 individuals identified from the database of a local energy company. The screening consisted of collection of demographic data, history of diabetes mellitus, hypertension, kidney/cardiovascular disease in the family and obesity through the body mass index - BMI (CKD risk factors). Blood samples were collected for determination of serum creatinine and subsequent eGFR estimation by the MDRD formula and urine samples for determination of albuminuria by dipstick. Albuminuria was further evaluated by HemoCue© in a selected CKD risk group. Results: The population was predominantly Caucasians (93%), 64% were females and the mean age of participants was 45 years old (18-87). BMI (kg/m2) was 27±5. Albuminuria was found in 5.25% of individuals. 88.6% of this population had no CKD (eGFR &gt; 60 ml/min/1.73m2 & normoalbuminuria) and 11.4% were identified as having CKD, with majority on stages 3A (7.2%) and 3B (1.1%). Hypertension, diabetes, older age and obesity was associated with a higher prevalence of CKD (p &lt; 0.001). Conclusions: The prevalence of CKD in an urban population in southern Brazil mirrors other developed countries and indicates that kidney disease is an important public health problem in Brazil.
DOI: 10.6084/m9.figshare.5772459
title: Influence of heat treatments on the microstructure and degree of sensitization of base metal and weld of AISI 430 stainless steel

description: ABSTRACT AISI 430 is a non-stabilized ferritic stainless steel grade with carbon content lower than 0.12%.After hot and cold rolling this material is annealed. The slow cooling after soaking at temperatures between 900oC and 1000oC promotes the formation of a high quantity of carbides and nitrides, while the rapid cooling partially suppresses the formation of these precipitates, but introduces martensite in the microstructure. Intergranular martensite can also be produced in the weld metal and in the heat affected zone (HAZ) of welds of non-stabilized ferritic stainless steels. In this work, several heat treatments between 900oC and 1000oC, with different cooling rates, were performed in a commercial sheet of AISI 430 grade. Also, an autogenous welding was produced with GTAW process, and post weld heat treatment at 700°C was carried out. The different microstructures produced were analyzed by optical and scanning electron microscopy (SEM). The degree of sensitization was measured by double loop electrochemical potentiodynamic tests (DL-EPR). The pitting corrosion resistance was evaluated by cyclic polarization tests in 3.5%NaCl solution. Hardness and toughness tests were also performed in selected heat treatment conditions. The results indicate that the slow cooling results in a higher degree of sensitization than observed in the material rapid cooled from the annealing temperature. The ferritic martensitic structure produced by water cooling has higher pitting potential and lower degree of sensitization, but is brittle at room temperature. A subsequent tempering treatment between 600 and 800oC can increase the toughness, but the corrosion resistance may decrease due to carbides precipitation.The heat affected zone of AISI 430 welds contains intergranular martensite, which is brittle and susceptible to corrosion attack. Post weld heat treatment at 700oC decomposed the martensite into ferrite and carbides and improved the corrosion resistance.
DOI: 10.6084/m9.figshare.5772459.v1
title: Influence of heat treatments on the microstructure and degree of sensitization of base metal and weld of AISI 430 stainless steel

description: ABSTRACT AISI 430 is a non-stabilized ferritic stainless steel grade with carbon content lower than 0.12%.After hot and cold rolling this material is annealed. The slow cooling after soaking at temperatures between 900oC and 1000oC promotes the formation of a high quantity of carbides and nitrides, while the rapid cooling partially suppresses the formation of these precipitates, but introduces martensite in the microstructure. Intergranular martensite can also be produced in the weld metal and in the heat affected zone (HAZ) of welds of non-stabilized ferritic stainless steels. In this work, several heat treatments between 900oC and 1000oC, with different cooling rates, were performed in a commercial sheet of AISI 430 grade. Also, an autogenous welding was produced with GTAW process, and post weld heat treatment at 700°C was carried out. The different microstructures produced were analyzed by optical and scanning electron microscopy (SEM). The degree of sensitization was measured by double loop electrochemical potentiodynamic tests (DL-EPR). The pitting corrosion resistance was evaluated by cyclic polarization tests in 3.5%NaCl solution. Hardness and toughness tests were also performed in selected heat treatment conditions. The results indicate that the slow cooling results in a higher degree of sensitization than observed in the material rapid cooled from the annealing temperature. The ferritic martensitic structure produced by water cooling has higher pitting potential and lower degree of sensitization, but is brittle at room temperature. A subsequent tempering treatment between 600 and 800oC can increase the toughness, but the corrosion resistance may decrease due to carbides precipitation.The heat affected zone of AISI 430 welds contains intergranular martensite, which is brittle and susceptible to corrosion attack. Post weld heat treatment at 700oC decomposed the martensite into ferrite and carbides and improved the corrosion resistance.
DOI: 10.6084/m9.figshare.5772456
title: Fosfomycin: a good alternative drug for prostate biopsy prophylaxis the results of a prospective, randomized trial with respect to risk factors

description: ABSTRACT Purpose: To determine the risk factors and the efficiency of rectal swab samples to prevent infectious complications in prostate biopsy, and compare fosfomycin with ciprofloxacin use in prophylaxis. Materials and Methods: Between May and October 2014, pre-biopsy risk factors and their effect in ciprofloxacin and fosfomycin prophylaxis were determined. Pre-biopsy urinalysis, urine culture and rectal swab samples were obtained from all of the patients. Rectal swabs were obtained upon admission, and biopsy was performed in the following 3-7 days. The place of rectal swab samples and efficiency of fosfomycin use was evaluated. Results: Pre-biopsy rectal swabs were obtained from 110 patients who revealed 60.9% fluoroquinolone resistance (FQR), and 32.7% fluoroquinolone sensitivity (FQS). Fosfomycin resistance was present in 3 patients. Ciprofloxacin use in last 6 months was the only risk factor for FQR. Antibiotic prophylaxis was given to both groups with and without risk factors, according to swab results, and no infective complications were observed. Among the group where fosfomycin was used empirically, one patient had an infection needing hospitalization, however this constitutes no statistical difference between the Group that fosfomycin used empirically or according to swab results (p=0.164). Conclusions: In prostate biopsy prophylaxis, ciprofloxacin may be used liberally in patients without risk factors, but it should be given according to the rectal swab results in the patients with risk, and fosfomycin may be used independently of risk factors and rectal swab results.
DOI: 10.6084/m9.figshare.5772456.v1
title: Fosfomycin: a good alternative drug for prostate biopsy prophylaxis the results of a prospective, randomized trial with respect to risk factors

description: ABSTRACT Purpose: To determine the risk factors and the efficiency of rectal swab samples to prevent infectious complications in prostate biopsy, and compare fosfomycin with ciprofloxacin use in prophylaxis. Materials and Methods: Between May and October 2014, pre-biopsy risk factors and their effect in ciprofloxacin and fosfomycin prophylaxis were determined. Pre-biopsy urinalysis, urine culture and rectal swab samples were obtained from all of the patients. Rectal swabs were obtained upon admission, and biopsy was performed in the following 3-7 days. The place of rectal swab samples and efficiency of fosfomycin use was evaluated. Results: Pre-biopsy rectal swabs were obtained from 110 patients who revealed 60.9% fluoroquinolone resistance (FQR), and 32.7% fluoroquinolone sensitivity (FQS). Fosfomycin resistance was present in 3 patients. Ciprofloxacin use in last 6 months was the only risk factor for FQR. Antibiotic prophylaxis was given to both groups with and without risk factors, according to swab results, and no infective complications were observed. Among the group where fosfomycin was used empirically, one patient had an infection needing hospitalization, however this constitutes no statistical difference between the Group that fosfomycin used empirically or according to swab results (p=0.164). Conclusions: In prostate biopsy prophylaxis, ciprofloxacin may be used liberally in patients without risk factors, but it should be given according to the rectal swab results in the patients with risk, and fosfomycin may be used independently of risk factors and rectal swab results.
DOI: 10.6084/m9.figshare.5772453
title: miR–483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5

description: ABSTRACT Objective: miR-483-5p has been identified as a miRNA oncogene in certain cancers. However, its role in prostate cancer has not been sufficiently investigated. In this study, we investigated the role of miR-483-5p in prostate cancer and examined RBM5 regulation by miR-483-5p. Material and methods: Expression levels of miR-483-5p were determined by quantitative real-time PCR. The effect of miR-483-5p on proliferation was evaluated by MTT assay, cell invasion was evaluated by trans-well invasion assays, and target protein expression was determined by western blotting in LNCaP, DU-145, and PC-3 cells. Luciferase reporter plasmids were constructed to confirm the action of miR-483-5p on downstream target gene RBM5 in HEK-293T cells. Results: we observed that miR-483-5p was upregulated in prostate cancer cell lines and tissues. A miR-483-5p inhibitor inhibited prostate cancer cell growth and invasion in DU-145 and PC-3 cells. miR-483-5p directly bound to the 3' untranslated region (3'UTR) of RBM5 in HEK-293T cells. RBM5 overexpression inhibited prostate cancer cell growth and invasion in LNCaP cells. Enforced RBM5 expression alleviated miR-483-5p promotion of prostate cancer cell growth and invasion in LNCaP cells. Conclusion: The present study describes a potential mechanism underlying a miR-483-5p/RBM5 link that contributes to prostate cancer development.
DOI: 10.6084/m9.figshare.5772453.v1
title: miR–483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5

description: ABSTRACT Objective: miR-483-5p has been identified as a miRNA oncogene in certain cancers. However, its role in prostate cancer has not been sufficiently investigated. In this study, we investigated the role of miR-483-5p in prostate cancer and examined RBM5 regulation by miR-483-5p. Material and methods: Expression levels of miR-483-5p were determined by quantitative real-time PCR. The effect of miR-483-5p on proliferation was evaluated by MTT assay, cell invasion was evaluated by trans-well invasion assays, and target protein expression was determined by western blotting in LNCaP, DU-145, and PC-3 cells. Luciferase reporter plasmids were constructed to confirm the action of miR-483-5p on downstream target gene RBM5 in HEK-293T cells. Results: we observed that miR-483-5p was upregulated in prostate cancer cell lines and tissues. A miR-483-5p inhibitor inhibited prostate cancer cell growth and invasion in DU-145 and PC-3 cells. miR-483-5p directly bound to the 3' untranslated region (3'UTR) of RBM5 in HEK-293T cells. RBM5 overexpression inhibited prostate cancer cell growth and invasion in LNCaP cells. Enforced RBM5 expression alleviated miR-483-5p promotion of prostate cancer cell growth and invasion in LNCaP cells. Conclusion: The present study describes a potential mechanism underlying a miR-483-5p/RBM5 link that contributes to prostate cancer development.
DOI: 10.6084/m9.figshare.5772450
title: Use of expanded clay and silica fume in improvement of mechanical, physical and thermal performances of structural lightweight concretes

description: ABSTRACT The search for sustainable materials in civil construction, which presents a lower specific mass, better thermal performance and maintenance of mechanical resistance, represents a great challenge in the production and evaluation of structural lightweight concrete (SLC), which emerges as an alternative material to conventional concrete. In this study an investigation was carried out for the construction of concretes with high strength, low density and excellent thermal properties, in order to execute energy-efficient constructions. SLC were studied using two different granulometries of expanded clay (C05 and C15), where the coarse aggregate was replaced by C15 at 0, 25, 50, 75 and 100%. To promote the maintenance of consistency and resistance, superplasticizer (SPA) and silica fume (SF) were used in the mixtures. Based on the methodology used, the concretes were physically and mechanically characterized, in accordance with current national and international standards. The density of the concretes, in the hardened state, ranged from 1,787 to 2,400 kg/m³ and, for compressive strength, ranged from 26 to 53 MPa at 7 days of age. The thermal conductivity test, using the protected hot plate method, was performed according to EN 12667, where was observed a variation of 0.61 to 1.00 W/mK. Microstructural information of the interfacial transition zone (ITZ) between aggregate and cement matrix were obtained with the purpose of analyzing the relationship with mechanical resistance. The investigation revealed that, with the addition of expanded clay (C05 and C15) and SF in the concretes, there was reduction of the density and the mechanical resistance, while the thermal characteristics were improved.