cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22548203.v1
title: Proposed Risk Score in Patients with Aortic Stenosis Submitted to Valve Replacement Surgery

description: ABSTRACT Introduction: Due to Brazilian population aging, prevalence of aortic stenosis, and limited number of scores in literature, it is essential to develop risk scores adapted to our reality and created in the specific context of this disease. Methods: This is an observational historical cohort study with analysis of 802 aortic stenosis patients who underwent valve replacement at Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul, from 1996 to 2018. With the aid of logistic regression, a weighted risk score was constructed based on the magnitude of the coeficients β of the logistic equation. Two performance statistics were obtained: area under the receiver operating characteristic curve and the chi-square (χ2) of Hosmer-Lemeshow goodness-of-fit with Pearson’s correlation coeficient between the observed events and predicted as a model calibration estimate. Results: The risk predictors that composed the score were valve replacement surgery combined with coronary artery bypass grafting, prior renal failure, New York Heart Association class III/IV heart failure, age &gt; 70 years, and ejection fraction &lt; 50%. The receiver operating characteristic curve area was 0.77 (95% confidence interval: 0.72-0.82); regarding the model calibration estimated between observed/predicted mortality, Hosmer-Lemeshow test χ2 = 3,70 (P=0.594) and Pearson’s coeficient r = 0.98 (P&lt;0.001). Conclusion: We propose the creation of a simple score, adapted to the Brazilian reality, with good performance and which can be validated in other institutions.
DOI: 10.6084/m9.figshare.22548204.v1
title: Relationship between abdominal and neck fat with sleep disorders in obese patients

description: Abstract Introduction Obesity is one of the main public health problem worldwide and it has a negative short- and long-term relationship with women's health. Assessment of this disorder is essential, as is a body composition assessed by dual-energy X-ray absorptiometry (DXA) with the new region of interest as the neck. Objective To verify the association between abdominal and neck fat with sleep quality in obese women. Methods The sample, obtained from a Biomedical Engineering and Health Program database, was characterized by being obese female aged between 20 and 65 years. The tests performed were anthropometric assessment, sleep quality questionnaire, physical activity level, nutritional assessment, and body composition by dual-energy X-ray absorptiometry (DXA). For statistical analysis, the Shapiro-Wilk test, t test for independent samples, Kendall's Tau, linear and multiple regression and ROC curve were used. Results The sample consisted of 15 individuals with a mean age of 45 ± 11.10 years, neck circumference of 41.50 ± 2.61 and abdominal circumference of 128.20 ± 11.62. We found no correlation between the regions of interest and the sleep quality questionnaire. Regression analysis shows non-significant statistical values for abdominal fat. The statistical test proved that the new region of interest in abdominal fat is closer to better sensitivity and has a greater relationship with sleep quality. Conclusion there was no statistically significant correlation between the regions of interest and the sleep quality questionnaire. However, the abdominal fat region of interest was the point that presented the best association with sleep quality assessed by the Pittsburgh questionnaire.
DOI: 10.6084/m9.figshare.22548204
title: Relationship between abdominal and neck fat with sleep disorders in obese patients

description: Abstract Introduction Obesity is one of the main public health problem worldwide and it has a negative short- and long-term relationship with women's health. Assessment of this disorder is essential, as is a body composition assessed by dual-energy X-ray absorptiometry (DXA) with the new region of interest as the neck. Objective To verify the association between abdominal and neck fat with sleep quality in obese women. Methods The sample, obtained from a Biomedical Engineering and Health Program database, was characterized by being obese female aged between 20 and 65 years. The tests performed were anthropometric assessment, sleep quality questionnaire, physical activity level, nutritional assessment, and body composition by dual-energy X-ray absorptiometry (DXA). For statistical analysis, the Shapiro-Wilk test, t test for independent samples, Kendall's Tau, linear and multiple regression and ROC curve were used. Results The sample consisted of 15 individuals with a mean age of 45 ± 11.10 years, neck circumference of 41.50 ± 2.61 and abdominal circumference of 128.20 ± 11.62. We found no correlation between the regions of interest and the sleep quality questionnaire. Regression analysis shows non-significant statistical values for abdominal fat. The statistical test proved that the new region of interest in abdominal fat is closer to better sensitivity and has a greater relationship with sleep quality. Conclusion there was no statistically significant correlation between the regions of interest and the sleep quality questionnaire. However, the abdominal fat region of interest was the point that presented the best association with sleep quality assessed by the Pittsburgh questionnaire.
DOI: 10.6084/m9.figshare.22548206.v1
title: Discovery of drugs to combat covid-19 inspired by traditional Chinese medicine

description: Abstract Contributions from traditional knowledge and history have proven useful in recent years to advance drug discovery. In response to the emergence of covid-19, scientists revisited traditional Chinese medicine. This source of inspiration for drugs to treat this new disease is described here at three different levels: traditional Chinese medicinal herbs, traditional Chinese medical formulas, and traditional Chinese medical texts. Drug discovery inspired by traditional Chinese medicine still faces serious resistance for various reasons, including its system of formulas and clinical trial design. A perspective that includes related issues would benefit the reasonable application of traditional knowledge in drug research and development.
DOI: 10.6084/m9.figshare.22548206
title: Discovery of drugs to combat covid-19 inspired by traditional Chinese medicine

description: Abstract Contributions from traditional knowledge and history have proven useful in recent years to advance drug discovery. In response to the emergence of covid-19, scientists revisited traditional Chinese medicine. This source of inspiration for drugs to treat this new disease is described here at three different levels: traditional Chinese medicinal herbs, traditional Chinese medical formulas, and traditional Chinese medical texts. Drug discovery inspired by traditional Chinese medicine still faces serious resistance for various reasons, including its system of formulas and clinical trial design. A perspective that includes related issues would benefit the reasonable application of traditional knowledge in drug research and development.
DOI: 10.6084/m9.figshare.22548207
title: Is Age Associated with Complications of Atrial Fibrillation Catheter Ablation?

description: Abstract Background Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence increases with age. The management of AF in the elderly is challenging, as it is normally associated with comorbidities and frailty. AF catheter ablation (CA) is a safe and superior alternative to antiarrhythmic drugs (AADs) for the maintenance of sinus rhythm. Objectives To evaluate the rate of complications associated with CA for AF across different age groups. Methods A retrospective analysis of 219 patients who underwent CA for AF between 2016 and 2020 were divided into 3 age groups: less than 60 years, 60 to 70 years, and &gt; 70 years. All the included patients underwent radiofrequency ablation using an electroanatomic mapping system. Categorical variables were evaluated with chi-square and Fisher’s test, and continuous variables were evaluated by Kruskal-Wallis and post-hoc Tamhane’s T2. P values less than 0.05 were considered significant. Results We found an overall total complication rate of 4.6%. The total complication rate was 3.3% in patients &lt; 60 years of age, 5.7% in patients between 60 and 70 years, and 5.2% in patients &gt; 70 years (p = 0.742). No deaths occurred. Conclusion There was no significant difference in the AF CA-related complications when comparing the patients by age group.
DOI: 10.6084/m9.figshare.22548207.v1
title: Is Age Associated with Complications of Atrial Fibrillation Catheter Ablation?

description: Abstract Background Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence increases with age. The management of AF in the elderly is challenging, as it is normally associated with comorbidities and frailty. AF catheter ablation (CA) is a safe and superior alternative to antiarrhythmic drugs (AADs) for the maintenance of sinus rhythm. Objectives To evaluate the rate of complications associated with CA for AF across different age groups. Methods A retrospective analysis of 219 patients who underwent CA for AF between 2016 and 2020 were divided into 3 age groups: less than 60 years, 60 to 70 years, and &gt; 70 years. All the included patients underwent radiofrequency ablation using an electroanatomic mapping system. Categorical variables were evaluated with chi-square and Fisher’s test, and continuous variables were evaluated by Kruskal-Wallis and post-hoc Tamhane’s T2. P values less than 0.05 were considered significant. Results We found an overall total complication rate of 4.6%. The total complication rate was 3.3% in patients &lt; 60 years of age, 5.7% in patients between 60 and 70 years, and 5.2% in patients &gt; 70 years (p = 0.742). No deaths occurred. Conclusion There was no significant difference in the AF CA-related complications when comparing the patients by age group.
DOI: 10.6084/m9.figshare.22548210.v1
title: Comparison of multistranded wire and fiber-reinforced composite retainers effects on periodontium: A randomized clinical trial

description: ABSTRACT Introduction: Fixed orthodontic retainers are very important for treatment stability; however, adverse effects on the health of periodontium can be caused as a result of deposition of plaque and calculus. Objectives: To compare and determine the effects of two mandibular fixed lingual retainers on the periodontal status, and to test the null hypothesis that there would be no significant difference on the periodontium health between the patients using fiber-reinforced composite (FRC) or multistranded wire (MSW) fixed retainers. Methods: A total of 60 subjects were recruited, out of which 6 were excluded and 2 dropped out during the study. Hence, 52 subjects with mean age of 21.5 ± 3.6 years were included in the study. The sample was composed by 8 males (15.4%) and 44 females (84.6%). The participants were randomly divided into two groups: Group 1 received fiber-reinforced composite retainer, while Group 2 received multistranded wire retainer. After insertion, plaque index, calculus index, gingival index and bleeding on probing were compared, after three months (T1), six months (T2), nine months (T3) and twelve months (T4), using Mann-Whitney test with p-value ≤ 0.05 as significant. Results: It could be seen that the health of periodontium deteriorated with the passage of time from T1 to T4 in both group of retainers. However, no statistically significant differences were found between the two groups (p&gt; 0.05). Conclusion: The results of the study indicate that there was no significant difference on the health of periodontium between the patients with FRC and MSW fixed retainers, hence, the null hypothesis was accepted.
DOI: 10.6084/m9.figshare.22548215.v1
title: Effects of microencapsulated carvacrol and cinnamaldehyde on feed digestibility, intestinal mucosa, and biochemical and antioxidant parameters in broilers

description: ABSTRACT The objective of this study was to evaluate the effects of different levels of microencapsulated carvacrol and cinnamaldehyde on metabolizable energy, feed digestibility, intestinal morphometric analysis, and antioxidant parameters in broilers. A completely randomized design with five treatments and eight replications of eight broilers (Cobb male) was used, and collections were carried out at 20 and 42 days of age. Carvacrol and cinnamaldehyde concentrations (mg/kg) were: 0 (control), 50, 100, 150, and 200. Carvacrol and cinnamaldehyde improved apparent metabolizable energy but did not change protein and ether extract digestibility. Supplementation increased intestinal villus height and villi:crypt ratio; in which 100 mg/kg produced the greatest villus height. Serum uric acid levels were lower in birds receiving supplementation. Improvement in the activity of glutathione peroxidase and glutathione-S-transferase was observed, while lower uric acid, thiobarbituric acid reactive substances, and reactive oxygen species levels were observed. Microencapsulated carvacrol and cinnamaldehyde improve apparent metabolizable energy and can be administered in broiler feed without risk to the bird’s health. These supplements may serve as alternative products to aid the performance of commercial poultry.
DOI: 10.17632/gfhmkbjzmx.1
title: The early warning significance of cytokines in children with type 1 diabetic ketoacidosis complicated with cerebral edema

description: Abstract Objective To explore the clinical significance of cytokines in children with type 1 diabetic ketoacidosis complicated with cerebral edema, and to provide early warning indicators for type 1 diabetic ketoacidosis complicated with cerebral edema. Methods A total of 73 children with diabetic ketoacidosis ( DKA ) aged 1-15 years old who were hospitalized in the Department of Endocrinology from January 2017 to January 2022 were selected, including 48 children in the simple DKA group and 25 children in the DKACE group. The blood gas analysis, electrolyte, white blood cell count on admission, C-reactive protein, interleukin-1, interleukin-2, interleukin-4, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-α, interferon-γ, interleukin-2 receptor were compared between the two groups, and the differences between the two groups were analyzed. Results The results of univariate analysis showed that the levels of IL-2, IL-4, IL-6, IL-10, TNF-α, IL-2R, blood glucose, urea nitrogen and serum creatinine in DKACE group were higher than those in DKA group ( P <0.05 ) and higher than those in DKA group ( P < 0.05 ), and the PH value,PaCO2, HCO3-and K + were lower than those in DKA group ( P < 0.05 ). ROC curve analysis showed that the area under the curve of IL-4 combined with blood glucose detection was 0.908, and the combination of the two detection indexes could improve the sensitivity or specificity compared with the single detection index. The sensitivity of IL-6 combined with blood glucose detection for DKACE was 96 %, and the specificity was 87.5 %. Conclusion ( 1 ) Blood glucose, PH value, HCO3-, urea nitrogen, serum creatinine, IL-2, IL-4, IL-6, IL-10, TNF-α, IL-2R can be used as early warning indicators of DKACE. ( 2 ) The combination of the two detection indicators can improve the sensitivity or specificity compared with the single detection index, and provide the basis for the early identification and early treatment of DKACE.
DOI: 10.6084/m9.figshare.22548225
title: Relationship between BUN/Cr and Prognosis of HF Across the Full Spectrum of Ejection Fraction

description: Abstract Background In patients with heart failure (HF), due to the relative deficiency of blood volume, neurohormone system activation leads to renal vasoconstriction, which affects the content of blood urea nitrogen (BUN) and creatinine (Cr) in the body, while BUN and Cr are easily affected by other factors. Therefore, BUN/Cr can be used as another marker for the prognosis of HF. Objective Explore the prognosis of adverse outcome of HF in the high BUN/Cr group compared with the low BUN/Cr group across the full spectrum of ejection fraction. Methods From 2014 to 2016, symptomatic hospitalized HF patients were recruited and followed up to observe adverse cardiovascular outcomes. Logistic analysis and COX analysis were performed to determine significance. p-values &lt;0.05 were considered statistically significant. Results In the univariate logistic regression analysis, the high BUN/Cr group had a higher risk of adverse outcome in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Multivariate logistic regression analysis showed that the risk of cardiac death in the HFrEF group was higher than that in the low BUN/Cr group, while the risk of all-cause death was significant only in 3 months (p&lt;0.05) (Central Illustration). The risk of all-cause death in the high BUN/Cr in the HFpEF group was significantly higher than that in the low BUN/Cr group at two years. Conclusion The high BUN/Cr group is related to the risk of poor prognosis of HFpEF, and is not lower than the predictive value of left ventricular ejection fraction (LVEF).
DOI: 10.6084/m9.figshare.22548225.v1
title: Relationship between BUN/Cr and Prognosis of HF Across the Full Spectrum of Ejection Fraction

description: Abstract Background In patients with heart failure (HF), due to the relative deficiency of blood volume, neurohormone system activation leads to renal vasoconstriction, which affects the content of blood urea nitrogen (BUN) and creatinine (Cr) in the body, while BUN and Cr are easily affected by other factors. Therefore, BUN/Cr can be used as another marker for the prognosis of HF. Objective Explore the prognosis of adverse outcome of HF in the high BUN/Cr group compared with the low BUN/Cr group across the full spectrum of ejection fraction. Methods From 2014 to 2016, symptomatic hospitalized HF patients were recruited and followed up to observe adverse cardiovascular outcomes. Logistic analysis and COX analysis were performed to determine significance. p-values &lt;0.05 were considered statistically significant. Results In the univariate logistic regression analysis, the high BUN/Cr group had a higher risk of adverse outcome in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Multivariate logistic regression analysis showed that the risk of cardiac death in the HFrEF group was higher than that in the low BUN/Cr group, while the risk of all-cause death was significant only in 3 months (p&lt;0.05) (Central Illustration). The risk of all-cause death in the high BUN/Cr in the HFpEF group was significantly higher than that in the low BUN/Cr group at two years. Conclusion The high BUN/Cr group is related to the risk of poor prognosis of HFpEF, and is not lower than the predictive value of left ventricular ejection fraction (LVEF).
DOI: 10.6084/m9.figshare.22548230.v1
title: EVALUATION OF OILSEED RADISH ( Raphanus sativus L. var. oleiformis Pers.) OIL AS A POTENTIAL COMPONENT OF BIOFUELS

description: ABSTRACT The growing interest in alternative fuels based on plant oils has led to the search for new plant species. Given this, during 2015–2020, oil from 12 varieties of oilseed radish was studied using standard research protocols. The average content of the dominant fatty acids in the oils studied was: [cis-9] oleic (C 18:1) 33.95% (Cv = 14.2%), [cis-9,12] linoleic (C 18:2) 16.20% (Cv = 20.8%), [cis-13] erucic (C 22:1) 15.18% (Cv = 17.9%), [cis-9, 12, 15] α-linolenic (C 18:3) 13.33% (Cv = 18.5%) and palmitic (C 16:0) 5.42% (Cv = 18.5%), with a monounsaturated fatty acid content of 59.69% and a ratio of polyunsaturated/monounsaturated fatty acids of 0.508. The studied varieties were ranked in the order of increasing suitability as a component of biofuels: ‘Zhuravka’ &lt; ‘Raiduha’ &lt; ‘Lybid’ &lt; ‘Olga’ &lt; ‘Iveya’ &lt; ‘Ramonta’ &lt; ‘Alpha’ &lt; ‘Tambovchanka’ &lt; ‘Fakel’ &lt; ‘Snizhana’ &lt; ‘Sabina’ &lt; ‘Nika’. The technological suitability of oil from the ‘Zhuravka’ variety was confirmed based on analysis of its physicochemical parameters when subjected to polymerization (at 280 °C) and oxypolymerization (at 120 and 150 °C). Under these conditions the basic parameters of the oil varied within the technological limits that determine its suitability for thermodynamic combustion processes in systems with controlled pressure and temperature.
DOI: 10.6084/m9.figshare.22548230
title: EVALUATION OF OILSEED RADISH ( Raphanus sativus L. var. oleiformis Pers.) OIL AS A POTENTIAL COMPONENT OF BIOFUELS

description: ABSTRACT The growing interest in alternative fuels based on plant oils has led to the search for new plant species. Given this, during 2015–2020, oil from 12 varieties of oilseed radish was studied using standard research protocols. The average content of the dominant fatty acids in the oils studied was: [cis-9] oleic (C 18:1) 33.95% (Cv = 14.2%), [cis-9,12] linoleic (C 18:2) 16.20% (Cv = 20.8%), [cis-13] erucic (C 22:1) 15.18% (Cv = 17.9%), [cis-9, 12, 15] α-linolenic (C 18:3) 13.33% (Cv = 18.5%) and palmitic (C 16:0) 5.42% (Cv = 18.5%), with a monounsaturated fatty acid content of 59.69% and a ratio of polyunsaturated/monounsaturated fatty acids of 0.508. The studied varieties were ranked in the order of increasing suitability as a component of biofuels: ‘Zhuravka’ &lt; ‘Raiduha’ &lt; ‘Lybid’ &lt; ‘Olga’ &lt; ‘Iveya’ &lt; ‘Ramonta’ &lt; ‘Alpha’ &lt; ‘Tambovchanka’ &lt; ‘Fakel’ &lt; ‘Snizhana’ &lt; ‘Sabina’ &lt; ‘Nika’. The technological suitability of oil from the ‘Zhuravka’ variety was confirmed based on analysis of its physicochemical parameters when subjected to polymerization (at 280 °C) and oxypolymerization (at 120 and 150 °C). Under these conditions the basic parameters of the oil varied within the technological limits that determine its suitability for thermodynamic combustion processes in systems with controlled pressure and temperature.