cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7484525.v1
title: Supplementary Material for: Perception of Risk for Older Adults: Differences in Evaluations for Self versus Others and across Risk Domains

description: <b><i>Background and Objectives:</i></b> Proxy decision-making may be flawed by inaccurate perceptions of risk. This may be particularly true when older adults are the targets of the decisions, given the pervasive negative stereotypes about older adults. <b><i>Methods:</i></b> In study 1, individuals aged 18- to 87 years (as target persons) as well as one of their close social partners (as informants) reported on the risks they perceived for the target person in various life domains. Study 2 additionally explored potential differences in how people make risky decisions on behalf of younger and older adult targets. Younger (age 18–35 years) and older (age 60–81 years) adults (as target persons of the risk evaluations) as well as informants reported on risk perceptions and the likelihood of risk-taking for health, financial, and social scenarios concerning the target persons. Congruence between self-rated and informant-rated risk perceptions and risk-taking were computed on a dyadic as well as a group level. <b><i>Results:</i></b> Informants’ risk perceptions were positively associated with the risks their partners perceived for themselves. Informants and their partners agreed that social risks vary little across adulthood, but they disagreed in terms of recreational, financial, and health risks, and in terms of the decisions they would make. <b><i>Conclusion:</i></b> Family members, partners, and close friends are sensitive to vulnerabilities of their social partners, but in some domains and according to their partners’ age they perceive a greater (or smaller) risk than their partners perceive for themselves. In situations requiring surrogate decision-making, people may decide differently from how their social partners would decide for themselves.
DOI: 10.6084/m9.figshare.27074323.v1
title: Rawdata for Jiang et al. Global distribution of Reactive iron oxides

description: Raw data and the R code used in the study of Global distribution of Reactive iron oxides
DOI: 10.6084/m9.figshare.19418978.v1
title: Supplementary Material for: Clinicopathological Spectrum of Cryoglobulinemic Glomerulonephritis without Evidence of Autoimmunity Disorders: A Retrospective Study from a Single Institute of China

description: <b><i>Background:</i></b> Cryoglobulinemic glomerulonephritis (Cryo-GN), caused by circulating cryoglobulins, has varied etiology and clinical-pathologic manifestations. This study aimed to investigate the clinicopathological spectrum and outcome of patients with various Cryo-GN in China. <b><i>Methods:</i></b> A retrospective review of 74 Chinese patients with biopsy-proven cryoglobulin-related renal lesions in Peking University First Hospital from 2010 to 2020 was performed. <b><i>Results:</i></b> The mean age at diagnosis was 52.9 ± 15.0 years, and the female-to-male ratio was about 2/5. For the etiology screening, serum/urine monoclonal immunoglobulin could be detected on immunofixation electrophoresis in 34% of patients, including 6 patients who had hematological malignancies. Fifty-seven percent of patients had HBV infection, far more than HCV infection (5%). Ten percent of patients had other infections, and 27% of patients were classified as essential or idiopathic. Eleven out of the 15 patients with type II cryoglobulinemia had a consistent monotype of serum monoclonal immunoglobulins and monoclonal cryoprecipitate. The clinical manifestations were similar between various types of cryoglobulinemia. Hematuria, proteinuria, hypertension, anemia, and chronic renal insufficiency were the most common features. Fifty-three percent of patients presented with nephrotic syndrome, and 32% experienced acute kidney injury. Hypocomplementemia, serum-positive rheumatoid factor activity, and skin lesions were reported in 45%, 29%, and 28% of patients, respectively. After a median of 24 months follow-up, 18 patients reached end-stage kidney disease. The clone-targeted treatment could retard the renal deterioration compared with immunosuppressive therapy. <b><i>Conclusions:</i></b> This was the largest single-center, clinicopathological retrospective study of Cryo-GN in China. Our data strongly support the association between monoclonal gammopathy and type II Cryo-GN. The renal responsive rate of immunosuppressant therapy is still suboptimal. The clone-targeted treatment shows promising effects in patients with type I or II Cryo-GN.
DOI: 10.6084/m9.figshare.14813520.v1
title: Original data of LSC.xlsx

description: Two Years Follow-up of a Novel Laparoscopic Sacrocolpopexy for Severe Pelvic Organ Prolapse: A Before and After Study
DOI: 10.6084/m9.figshare.6226745.v1
title: Supplementary Material for: A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

description: <b><i>Background:</i></b> Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. <b><i>Summary:</i></b> Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/ dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). <b><i>Key Messages:</i></b> AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller.
DOI: 10.6084/m9.figshare.5128516.v1
title: Supplementary Material for: Effectiveness of a Web-Based Cognitive Behavioural Intervention for Subthreshold Depression: Pragmatic Randomised Controlled Trial

description: <b><i>Background:</i></b> Research on the effectiveness of treatments for subthreshold depression (sD) is still scarce. The aim of the study was to evaluate the efficacy of a web-based guided self-help intervention (GET.ON Mood Enhancer) in the treatment of sD. <b><i>Methods:</i></b> Participants with sD (n = 406) recruited from the general population via a large health insurance company were randomly allocated to a web-based cognitive behavioural intervention or to enhanced care-as-usual. The primary outcome was the reduction in depressive symptom severity as measured with the Center for Epidemiological Studies Depression Scale at post-treatment and at 6-month follow-up. <b><i>Results:</i></b> Participants in the intervention group showed a significantly greater pre-post reduction in depressive symptom severity (d = 1.06; 95% CI: 0.86-1.27) compared to the control condition (d = 0.29; 95% CI: 0.10-0.49). The corresponding between-group effect size was d = 0.69 (95% CI: 0.49-0.89). At 6-month follow-up the effect was reduced to d = 0.28 (95% CI: 0.09-0.48) but was still statistically significant (F<sub>1, 403</sub> = 9.240, p = 0.003). <b><i>Conclusions:</i></b> This study lends support to the idea that problem solving coupled with behavioural activation is an effective treatment for sD. In addition, the delivery of this intervention over the Internet might be a promising strategy for the dissemination of psychological interventions for sD on a large scale.
DOI: 10.6084/m9.figshare.6450215.v1
title: Supplementary Material for: Increased Susceptibility to Allergic Asthma with the Impairment of Respiratory Tolerance Caused by Psychological Stress

description: <b><i>Background:</i></b> Bronchial asthma is characterized by type 2 T helper (Th2) cell inflammation, essentially due to a breakdown of immune tolerance to harmless environmental allergens. Etiologically, experiences of psychological stress can be associated with a heightened prevalence of asthma. However, the mechanisms underlying stress-related asthma development are unclear. In this study, we examined whether psychological stress increases susceptibility to allergic asthma by downregulating immune tolerance. <b><i>Methods:</i></b> Female BALB/c mice were sensitized with ovalbumin/alum, followed by ovalbumin inhalation. Ovalbumin inhalation induced immune tolerance before sensitization occurred. Some mice were exposed to restraint stress during tolerance induction or sensitization. Asthma development was evaluated by airway responsiveness, inflammation, cytokine expression, and IgE synthesis. Sensitization was evaluated by measuring proliferation and cytokine production by splenocytes. The effects of stress exposure on the numbers and functions of dendritic cells and regulatory T (Treg) cells in bronchial lymph nodes and spleens were evaluated. To investigate the role of endogenous glucocorticoid in inhibiting immune tolerance after stress exposure, we examined the effects of (i) a glucocorticoid-receptor antagonist administered prior to stress exposure, and (ii) exogenous gluco­corticoid (instead of stress exposure). <b><i>Results:</i></b> Asthmatic responses and Th2-biased sensitization, which were suppressed in tolerized mice, re-emerged in tolerized mice stressed during tolerance induction in association with decreased tolerogenic dendritic and Treg cell numbers. The effects of stress exposure on tolerized mice were abolished by administering a glucocorticoid-receptor antagonist and reproduced by administering exogenous glucocorticoid without stress. <b><i>Conclusions:</i></b> Our findings suggested that psychological stress can potentially increase allergic asthma susceptibility by inhibiting immune tolerance.
DOI: 10.6084/m9.figshare.24681309.v1
title: Anonymised Phase2 Data related to study: Prescribing hand strengthening exercises for patients with rheumatoid arthritis; clinical cues influencing occupational therapists’ and physiotherapists’ judgements.

description: Using judgement analysis to investigate the judgements of occupational therapists’ and physiotherapists’ prescribing hand strengthening exercise in rheumatoid arthritis.
DOI: 10.6084/m9.figshare.3486749.v1
title: Mojave National Preserve 2013 insect diversity data.csv

description: The primary data for this publication: Ruttan, A., Filazzola, A. and Lortie, C. J. (2016) Shrub-annual facilitation complexes mediate insect community structure in arid environments. Journal of Arid Environments 134: 1-9.http://www.sciencedirect.com/science/article/pii/S0140196316301100<br> Insect samples were collected at Kelso dunes over a nine-day period between April 24th and May 2nd, 2013. Insects were sampled daily using pan traps (approximately 18 cm in diameter) set at ground-level along an east-west axis parallel to Kelso Dunes. Thirty pairs of pan traps were set along two parallel 45 m transects (transects were 10 m apart) with alternating blue, yellow, and white traps approximately every 3 m using the NSERC-CANPOLIN protocol (http://www.uoguelph.ca/canpolin). Pan traps were paired so that each replicate had one pan trap under the southern portion of a L. tridentata canopy, halfway between the base of the shrub and the drip-line, and within a patch of annual plants. The other pan traps were deployed 2 m south of each paired shrub in an adjacent open microsite, also with annual plants present (see Appendix A; Fig. A2). Open microsites were located two metres from the drip-line of shrubs because this was on average the maximum distance possible without being within a two metre radius of another shrub (Ruttan pers. obs). Pan traps were half-filled with a solution of soapy water prepared by mixing five drops of unscented dish detergent per litre of water (for protocol, see: http://www.uoguelph.ca/canpolin). Pan traps were set out by 9:00 a.m. and collected at 5:00 p.m. daily targeting typical peak insect activity (http://www.uoguelph.ca/canpolin). All samples were collected on sunny days with no precipitation. Samples were collected from each pan trap replicate and stored in vials of 70% ethanol. Insects were then sorted from samples and identified to the family level for ease of identification using Goulet and Huber (1993) and Borror et al. (1989). <br>
DOI: 10.6084/m9.figshare.5480710.v3
title: State of Open Data survey 2017

description: Anonymised raw data from Digital Science Open Data survey 2017
DOI: 10.6084/m9.figshare.16649728.v2
title: OD600 readings_AB5075.xlsx

description: OD600 readings of AB5075 at harvested timepoint
DOI: 10.6084/m9.figshare.19522255.v12
title: Data scientist search behaviour

description: The repo contains artifacts of survey study and interviews with data scientists on understanding their search behaviour in online resources.
DOI: 10.6084/m9.figshare.12594290.v1
title: Supplementary Material for: Proinflammatory α-Adrenergic Neuronal Regulation of Splenic IFN-γ, IL-6, and TGF-β of Mice from Day 15 onwards in Arthritis

description: <b><i>Introduction:</i></b> In arthritic mice, a sympathetic influence is proinflammatory from the time point of immunization until the onset of disease (days 0–32), but reasons are unknown. Disruption of the major anti-inflammatory pathway through G<sub>αs</sub>-coupled receptors probably play a role. For example, noradrenaline cannot operate via anti-inflammatory β<sub>2</sub>-adrenoceptors but through proinflammatory α<sub>1/2</sub>-ad­renoceptors. This might happen, first, through a loss of sympathetic nerve fibers in inflamed tissue with low neurotransmitter levels (noradrenaline only binds to high-affinity α-adrenoceptors) and, second, through an alteration in G-protein receptor coupling with a predominance of α-adrenergic signaling. We hypothesized that both mechanisms play a role in the course of collagen type II-induced arthritis (CIA) in the spleen in mice. <b><i>Methods:</i></b> In CIA mice, nerve fiber density in the spleen was quantified by immunohistochemistry techniques. The functional impact of sympathetic nerve fibers in the spleen was studied by a micro­superfusion technique of spleen slices with a focus on the secretion of IFN-γ and IL-6 (proinflammatory) and TGF-β (anti-inflammatory). <b><i>Results:</i></b> During CIA, sympathetic nerve fibers get increasingly lost from day14 until day 55 after immunization. The influence of electrically released noradrenaline diminishes in the course of arthritis. At all investigated time points (days 14, 32, and 55), only proinflammatory neuronal α-adrenergic effects on cytokine secretion were demonstrated (i.e., stimulation of IFN-γ and IL-6 and inhibition of TGF-β). <b><i>Conclusion:</i></b> Sympathetic nerve fibers are rapidly lost in the spleen, and only proinflammatory α-adrenergic neuronal regulation of cytokine secretion takes place throughout the course of arthritis. These results support a predominance of a proinflammatory α-adrenergic sympathetic influence in arthritis.
DOI: 10.6084/m9.figshare.28458275.v1
title: Supplementary Material for: Prognostic impact of coronary calcifications in patients with recently diagnosed prostate cancer

description: Background. Patients with prostate cancer are at increased risk of cardiovascular events. A non-electrocardiogram gated CT scan of the thorax is part of the diagnostic workup, allowing for assessment of coronary calcifications. However, the prognostic impact of a coronary artery calcium score (CACS) obtained from such CT scans is uncertain.
Objectives. To investigate the association between CACS and a combined endpoint of all-cause death, myocardial infarction, or stroke in patients with recently diagnosed prostate cancer. 
Methods. The primary analysis included patients (N=571) with recently diagnosed prostate cancer and without known coronary artery disease undergoing prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT). Patients were stratified into four CACS groups. Cox proportional hazard models adjusted for risk factors were used to examine the association between CACS and the combined endpoint.
Results. Patients were distributed in the four CACS groups as follows: CACS 0-10 (26%), 11-99 (21%), 100-399 (24%) and ≥400 (29%). An increased risk of the combined endpoint was found with increasing CACS. Compared with CACS 0-10, the hazard ratios for CACS 11-99, 100-399 and ≥400 were 0.95 (95% CI: 0.37-2.42), 2.39 (95% CI: 1.13-5.09) and 3.14 (95% CI: 1.52-6.48), respectively. Only 53% of patients in the CACS ≥400 group received statins. 
Conclusion. In patients with prostate cancer, assessment of a CACS from the initial PET/CT scan allows for the identification of patients with a threefold higher risk of death, myocardial infarction, or stroke. Initiation of preventive statin treatment in these patients could reduce cardiovascular events.
DOI: 10.6084/m9.figshare.21393337.v1
title: Ibuprofen biosorption by chemically activated Saccharomyces cerevisiae

description: Abstract Saccharomyces cerevisiae biomass was activated chemically, and its ibuprofen (IBP) biosorption capabilities were assessed regarding IBP removal from an aqueous solution. The effects of pH (2-10), contact time (0-90 min), IBP concentration (5-35 mg L-1), and temperature (20, 30, 40°C) were evaluated in batch studies. Higher removal rates of IBP were found at pH 2.0. The pseudo-second-order kinetic model best described the experimental data. Both the Langmuir and Freundlich isotherm models described the equilibrium data satisfactorily. The maximum biosorption capacity for IBP onto chemically activated Saccharomyces cerevisiae biomass (CA-YB) was estimated at 13.39 mg g-1 at 40°C. The activation energy calculated by the Dubinin-Radushkevich isotherm model was 9.129 kJ mol-1, indicating that a chemical process mediated the biosorption of IBP onto CA-YB. According to thermodynamic studies, IBP biosorption is spontaneous and endothermic. FTIR analysis revealed that the carboxyl, hydroxyl, phosphoryl, and amino groups were involved in the biosorption process of IBP. These findings indicated that CA-YB could be an alternative biosorbent for IBP removal from aqueous media.
DOI: 10.6084/m9.figshare.25608450.v1
title: GNSS data with RINEX format in UYBA station

description: GNSS data with RINEX format in UYBA station
DOI: 10.6084/m9.figshare.24449452.v2
title: Raw data of mNGS

description: We retrospectively enrolled 108 patients with infectious disease and noninfectious disease who visited West China Hospital of Sichuan University from January 2019 to June 2022. Pathogens in core needle biopsy tissue were detected using mNGS and traditional pathological examination. The diagnostic accuracy of the combined mNGS and histopathology protocol for pulmonary infectious diseases was contrasted with that of histopathological examination alone.The is the raw data of part patients who have completed mNGS of biopsy tissue.
DOI: 10.6084/m9.figshare.28668239.v1
title: Test Publish

description: This is a test
DOI: 10.6084/m9.figshare.9956858.v1
title: Interproscan annotation results of proteins in Chlorella vulgaris NJ-7

description: Interproscan annotation results of proteins in Chlorella vulgaris NJ-7
DOI: 10.6084/m9.figshare.28774421.v1
title: Sex-specific effects of hormones on endothelial cells and fibroblasts

description: Sex hormone exposure in 2D and 3D assays results in increased bioenergetics and proliferation in 2D and increased vasculogenesis in 3D. HLF, HOF, HUVEC, and HRMVEC were studied in 2D for TMRM amd Ki67 positivity as well as PCR analysis for genes related to bioenergetics and heat shock protein expression. In 3D, HLF and HUVEC self-generated vascular networks showed sensitivity to hormones as shown via vascular network analysis.<br>
DOI: 10.6084/m9.figshare.26035132.v1
title: <b>Analyzing the Impact of Student Research Groups in California's Dental Education Raw Data</b>

description: Research engagement is a vital component of dental education, fostering the development ofevidence-based practices and advancing the field of dentistry. Understanding factors thatinfluence research involvement among dental students can help enhance educational strategiesand support systems. The goal of this study was to understand patterns of research engagement,the impact of Student Research Groups (SRGs), and the future research aspirations of students inCalifornia dental schools using an online survey tool. Respondents (n=95) were predominantlyfrom UOP (45.3%), followed by UCLA (27.4%), and USC (9.5%), with the remaining fromLoma Linda, UCSF, and Western University. The majority (73.7%) of respondents hadundergraduate research experience. During their dental programs, 63.2% were members ofSRGs, with 54.7% involved in research. Only 18.9% joined SRGs in their first year.Additionally, 38.9% had presented their research at conferences, and 26.3% had published theirresearch. In the future, 52.6% of students plan to continue research after graduation. The surveyreveals a strong research engagement among dental students, from undergraduate involvement toactive participation during their graduate studies. The high level of SRG membership, conferencepresentations, and research publications indicate a vibrant research culture within Californiadental schools. However, there is potential to increase early engagement in SRGs. The positiveoutlook toward future research involvement underscores the need for continued promotion ofresearch opportunities within dental programs. Enhancing these opportunities will help cultivatea research-oriented mindset and contribute to the advancement of dental science.
DOI: 10.6084/m9.figshare.25092794.v1
title: Supplementary Material for: Cytopathology of chondromyxoid fibroma: Report of two cases with immunocytochemical expression of GRM1

description: Introduction: Chondromyxoid fibroma (CMF) is a rare, benign bone tumor that occurs predominantly in the second and third decades of life, more frequently in males. Overexpression of GRM1 as a consequence of tumor specific gene rearrangement of GRM1 has recently been reported as a useful immunohistochemical marker for histopathological diagnosis of CMF. However, the usefulness of GRM1 staining of cytology specimens has not yet been evaluated. In this report, the cytological findings and GRM1 immunocytochemistry of two cases of CMF are described.
Case Presentations: Case 1 was a 15-year-old girl with a rib tumor. Imaging findings suggested a benign neurogenic tumor such as schwannoma. The tumor had increased in size over a two-year period and was resected. Case 2 was a 14-year-old boy with a metatarsal tumor involving his left first toe. Imaging findings were suspicious of a benign neoplastic lesion. Biopsy findings suggested a benign tumor, and the patient underwent tumor resection. Cytologically, in both cases the tumor cells were predominantly spindle-shaped or stellate, with a myxoid to chondromyxoid background matrix and multinucleated giant cells, and these matrices were metachromatic with Giemsa staining. Cellular atypia was more accentuated in case 2 than in case 1. Immunocytochemical staining for GRM1 was positive in both cases.
Conclusion: Due to the overlap in cytological findings, it is often difficult to differentiate CMF from chondroblastoma and chondrosarcoma grade 2. Immunocytochemical staining for GRM1 may support the diagnosis of CMF, and the re-use of Papanicolaou-stained specimens is applicable. The present cases further demonstrated the difficulty of differentiating CMF from other mimicking tumors such as chondroblastoma and chondrosarcoma grade 2. In such instances, immunocytochemistry for GRM1 is applicable to the diagnostic process, the value of which is strengthened by reusing Papanicolaou-stained specimens.
DOI: 10.6084/m9.figshare.28882808.v1
title: meraklı_kelebek.sav

description: Data set includes state and trait anxiety scale results and MR image quality assessment scores of a total of 48 children aged 7-11 years (23 experimental, 25 control) who were to undergo MRI.