cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7899149.v1
title: Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis

description: The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress.
DOI: 10.6084/m9.figshare.7899134
title: Identification of a novel UMOD mutation (c.163G&gt;A) in a Brazilian family with autosomal dominant tubulointerstitial kidney disease

description: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is characterized by autosomal dominant inheritance, progressive chronic kidney disease, and a bland urinary sediment. ADTKD is most commonly caused by mutations in the UMOD gene encoding uromodulin (ADTKD-UMOD). We herein report the first confirmed case of a multi-generational Brazilian family with ADTKD-UMOD, caused by a novel heterozygous mutation (c.163G&gt;A, GGC→AGC, p.Gly55Ser) in the UMOD gene. Of 41 family members, 22 underwent genetic analysis, with 11 individuals found to have this mutation. Three affected individuals underwent hemodialysis, one peritoneal dialysis, and one patient received a kidney transplant from a family member later found to be genetically affected. Several younger individuals affected with the mutation were also identified. Clinical characteristics included a bland urinary sediment in all tested individuals and a kidney biopsy in one individual showing tubulointerstitial fibrosis. Unlike most other reported families with ADTKD-UMOD, neither gout nor hyperuricemia was found in affected individuals. In summary, we report a novel UMOD mutation in a Brazilian family with 11 affected members, and we discuss the importance of performing genetic testing in families with inherited kidney disease of unknown cause.
DOI: 10.6084/m9.figshare.7899140.v1
title: Evaluation of nitrate adsorption from aqueous medium using modified montmorillonites

description: ABSTRACT This study investigated the efficiency of nitrate removal in aqueous medium using adsorption on commercial montmorillonites compared to an anionic resin widely used in this operation. Some of these clays were intercalated with hexadecyltrimethylammonium ion for this investigation. Specific surface areas, cation exchange capacities and mid-infrared spectra were determined for clays characterization. Preliminary tests indicated that the nanoclay functionalized with aminopropyltriethoxysilane and octadecylamine was the most efficient in nitrate adsorption, although it did not exceed anionic resin in efficiency. Adsorption kinetic and equilibrium of nitrate from aqueous phase on the nanoclay and anionic resin were determined and modeled for comparison, as well as for the selection of representative models and estimation of thermodynamic properties of the studied systems. All experiments were carried out at 25°C and at pH 7. Equilibrium isotherms were also determined at 35 and 45°C. The obtained results show that the adsorption processes studied are physical, spontaneous and favorable for both the resin and the nanoclay, which have very good affinity with nitrate. The most representative models for the systems were the pseudo-second order kinetic model and the Freundlich equilibrium isotherm.
DOI: 10.6084/m9.figshare.7899143.v1
title: Life cycle assessment of Municipal Construction and Demolition Waste Management System of Campinas Metropolitan Region

description: ABSTRACT The absence or inefficiency of Municipal Construction and Demolition Waste Management Systems (MCDWMS) may cause environmental impacts, which need a systematic evaluation, considering the local reality. There are few studies on the environmental impacts’ quantification of construction and demolition waste (CDW) management. Thus, in this work, MCDWMS’ environmental performance of the municipalities in the metropolitan region of Campinas was evaluated based on the life cycle assessment (LCA) methodology. The LCA study was modeled using the SimaPro 8.2.0, and the environmental impacts were evaluated by the CML baseline 2000 method, considering the categories of global warming, human toxicity, photochemical oxidation, acidification and eutrophication. When comparing the current environmental performance with the scenario that includes a recycling rate of 70% of CDW Class A (goal established in the Solid Waste Plan of São Paulo State), the environmental impacts were reduced in 22%. However, when analyzing the scenarios individually for each municipality, it was verified that due to the transport distances, some municipalities did not present environmental benefits resulting from recycling. These results demonstrate that recycling should not be the first option in the MCDWMS, and that the adoption of source reduction and reuse of waste within the scope of CDW management is urgent. These results may support the decision-making process in CDW management systems, as currently many Brazilian municipalities are planning the implementation of recycling facilities.
DOI: 10.6084/m9.figshare.7899125
title: Optimal plant density and nitrogen rates for improving off-season corn yields in Brazil

description: ABSTRACT: Integrating plant density and nitrogen (N) management is a strategy for improving corn yields, especially for off-season corn production in the tropics. This study tested the hypothesis that increasing plant densities and N rates promotes yield gains for off-season corn production in high-yielding environments. The aim of the study was to investigate the yield performances of two hybrid versions (DKB PRO and DKB PRO3) submitted to three plant densities (55,000; 65,000 and 75,000 plants ha−1) and four N rates (control, 60, 120 and 180 kg ha−1 N). Field trials were undertaken at Uberlândia-MG (site1 and 2) and Pedro Afonso-TO (site 3), Brazil from which data on corn yield parameters were collected and analyzed. Multivariate analysis separated the three trial areas into two groups, presenting high (sites 1 and 2) and low yields (site 3), which were related to weather conditions. There was no influence of a hybrid version or plant densities on crop yields at site 1 or 2. In contrast, there was a positive response to increasing plant densities and the use of DKB PRO3 at site 3. A significant response to N was observed at sites 2 and 3, following a plateau model. Our results suggest that N application rates and plant densities do have the potential to increase off-season corn yields in low yielding environments.
DOI: 10.6084/m9.figshare.7899128
title: Alternative chromatographic system for the quality control of lipophilic technetium-99m radiopharmaceuticals such as [99mTc(MIBI)6]+

description: Knowledge of the radiochemical purity of radiopharmaceuticals is mandatory and can be evaluated by several methods and techniques. Planar chromatography is the technique normally employed in nuclear medicine since it is simple, rapid and usually of low cost. There is no standard system for the chromatographic technique, but price, separation efficiency and short time for execution must be considered. We have studied an alternative system using common chromatographic stationary phase and alcohol or alcohol:chloroform mixtures as the mobile phase, using the lipophilic radiopharmaceutical [99mTc(MIBI)6]+ as a model. Whatman 1 modified phase paper and absolute ethanol, Whatman 1 paper and methanol:chloroform (25:75), Whatman 3MM paper and ethanol:chloroform (25:75), and the more expensive ITLC-SG and 1-propanol:chloroform (10:90) were suitable systems for the direct determination of radiochemical purity of [99mTc(MIBI)6]+ since impurities such as 99mTc-reduced-hydrolyzed (RH),99mTcO4 - and [99mTc(cysteine)2]-complex were completely separated from the radiopharmaceutical, which moved toward the front of chromatographic systems while impurities were retained at the origin. The time required for analysis was 4 to 15 min, which is appropriate for nuclear medicine routines.
DOI: 10.6084/m9.figshare.7899131
title: Useful plants referenced by the naturalist Richard Spruce in the 19th century in the state of Pará, Brazil

description: ABSTRACT The present work sought to study the biocultural collections made by the naturalist Richard Spruce in the 19th century while in the state of Pará, Brazil. The material is largely deposited in the Herbarium and the Museum of Economic Botany at the Royal Botanic Gardens, Kew, UK. Complementary studies were undertaken in Brazilian institutions to gather more information about the useful plants cited by Spruce for Pará and their respective vernacular names and uses in the 19th century. Information was also gathered concerning the current uses of the plants by analyzing contemporary ethnobotanical studies. A total of 54 vernacular names of useful plants were recovered, including 51 native species of which 33 are used for construction purposes, 18 as food resources, eight for medicinal purposes, and one species as an ichthyotoxin. It is interesting to note that 80 % of the uses described for these plants in the 19th century in Pará continue into the present day. It is hoped that the present work will serve to promote future studies involving biocultural collections that document the history of local populations and recognize the importance of traditional knowledge in the Amazon region.
DOI: 10.6084/m9.figshare.7899134.v1
title: Identification of a novel UMOD mutation (c.163G&gt;A) in a Brazilian family with autosomal dominant tubulointerstitial kidney disease

description: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is characterized by autosomal dominant inheritance, progressive chronic kidney disease, and a bland urinary sediment. ADTKD is most commonly caused by mutations in the UMOD gene encoding uromodulin (ADTKD-UMOD). We herein report the first confirmed case of a multi-generational Brazilian family with ADTKD-UMOD, caused by a novel heterozygous mutation (c.163G&gt;A, GGC→AGC, p.Gly55Ser) in the UMOD gene. Of 41 family members, 22 underwent genetic analysis, with 11 individuals found to have this mutation. Three affected individuals underwent hemodialysis, one peritoneal dialysis, and one patient received a kidney transplant from a family member later found to be genetically affected. Several younger individuals affected with the mutation were also identified. Clinical characteristics included a bland urinary sediment in all tested individuals and a kidney biopsy in one individual showing tubulointerstitial fibrosis. Unlike most other reported families with ADTKD-UMOD, neither gout nor hyperuricemia was found in affected individuals. In summary, we report a novel UMOD mutation in a Brazilian family with 11 affected members, and we discuss the importance of performing genetic testing in families with inherited kidney disease of unknown cause.
DOI: 10.6084/m9.figshare.7899122
title: Long-term efficacy of a rural community-based integrated intervention for prevention and management of chronic obstructive pulmonary disease: a cluster randomized controlled trial in China's rural areas

description: This study aimed to assess the efficacy of a rural community-based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China. This 18-year cluster-randomized controlled trial encompassing 15 villages included 1008 patients (454 men and 40 women in the intervention group [mean age, 54 ± 10 years]; 482 men and 32 women in the control group [mean age, 53 ± 10 years]) with confirmed COPD or at risk for COPD. Villages were randomly assigned to the intervention or the control group, and study participants residing within the villages received treatment accordingly. Intervention group patients took part in a program that included systematic health education, smoking cessation counseling, and education on management of COPD. Control group patients received usual care. The groups were compared after 18 years regarding the incidence of COPD, decline in lung function, and mortality of COPD. COPD incidence was lower in the intervention group than in the control group (10% vs 16%, &lt;0.05). A decline in lung function was also significantly delayed in the intervention group compared to the control group of COPD and high-risk patients. The intervention group showed significant improvement in smoking cessation compared with the control group, and smokers in the intervention group had lower smoking indices than in the control group (350 vs 450, &lt;0.05). The intervention group also had a significantly lower cumulative COPD-related death rate than the control group (37% vs 47%, &lt;0.05). A rural community-based integrated intervention is effective in reducing the incidence of COPD among those at risk, delaying a decline in lung function in COPD patients and those at risk, and reducing mortality of COPD.
DOI: 10.6084/m9.figshare.7899125.v1
title: Optimal plant density and nitrogen rates for improving off-season corn yields in Brazil

description: ABSTRACT: Integrating plant density and nitrogen (N) management is a strategy for improving corn yields, especially for off-season corn production in the tropics. This study tested the hypothesis that increasing plant densities and N rates promotes yield gains for off-season corn production in high-yielding environments. The aim of the study was to investigate the yield performances of two hybrid versions (DKB PRO and DKB PRO3) submitted to three plant densities (55,000; 65,000 and 75,000 plants ha−1) and four N rates (control, 60, 120 and 180 kg ha−1 N). Field trials were undertaken at Uberlândia-MG (site1 and 2) and Pedro Afonso-TO (site 3), Brazil from which data on corn yield parameters were collected and analyzed. Multivariate analysis separated the three trial areas into two groups, presenting high (sites 1 and 2) and low yields (site 3), which were related to weather conditions. There was no influence of a hybrid version or plant densities on crop yields at site 1 or 2. In contrast, there was a positive response to increasing plant densities and the use of DKB PRO3 at site 3. A significant response to N was observed at sites 2 and 3, following a plateau model. Our results suggest that N application rates and plant densities do have the potential to increase off-season corn yields in low yielding environments.
DOI: 10.6084/m9.figshare.7899128.v1
title: Alternative chromatographic system for the quality control of lipophilic technetium-99m radiopharmaceuticals such as [99mTc(MIBI)6]+

description: Knowledge of the radiochemical purity of radiopharmaceuticals is mandatory and can be evaluated by several methods and techniques. Planar chromatography is the technique normally employed in nuclear medicine since it is simple, rapid and usually of low cost. There is no standard system for the chromatographic technique, but price, separation efficiency and short time for execution must be considered. We have studied an alternative system using common chromatographic stationary phase and alcohol or alcohol:chloroform mixtures as the mobile phase, using the lipophilic radiopharmaceutical [99mTc(MIBI)6]+ as a model. Whatman 1 modified phase paper and absolute ethanol, Whatman 1 paper and methanol:chloroform (25:75), Whatman 3MM paper and ethanol:chloroform (25:75), and the more expensive ITLC-SG and 1-propanol:chloroform (10:90) were suitable systems for the direct determination of radiochemical purity of [99mTc(MIBI)6]+ since impurities such as 99mTc-reduced-hydrolyzed (RH),99mTcO4 - and [99mTc(cysteine)2]-complex were completely separated from the radiopharmaceutical, which moved toward the front of chromatographic systems while impurities were retained at the origin. The time required for analysis was 4 to 15 min, which is appropriate for nuclear medicine routines.
DOI: 10.6084/m9.figshare.7899131.v1
title: Useful plants referenced by the naturalist Richard Spruce in the 19th century in the state of Pará, Brazil

description: ABSTRACT The present work sought to study the biocultural collections made by the naturalist Richard Spruce in the 19th century while in the state of Pará, Brazil. The material is largely deposited in the Herbarium and the Museum of Economic Botany at the Royal Botanic Gardens, Kew, UK. Complementary studies were undertaken in Brazilian institutions to gather more information about the useful plants cited by Spruce for Pará and their respective vernacular names and uses in the 19th century. Information was also gathered concerning the current uses of the plants by analyzing contemporary ethnobotanical studies. A total of 54 vernacular names of useful plants were recovered, including 51 native species of which 33 are used for construction purposes, 18 as food resources, eight for medicinal purposes, and one species as an ichthyotoxin. It is interesting to note that 80 % of the uses described for these plants in the 19th century in Pará continue into the present day. It is hoped that the present work will serve to promote future studies involving biocultural collections that document the history of local populations and recognize the importance of traditional knowledge in the Amazon region.
DOI: 10.6084/m9.figshare.7899113
title: Interleukin-27 augments the inhibitory effects of sorafenib on bladder cancer cells

description: Both sorafenib and interleukin-27 (IL-27) are antineoplastic drugs. This study aimed to investigate the synergistic effect of these two drugs on bladder cancer cells. HTB-9 and T24 cells were stimulated with IL-27 (50 ng/mL), sorafenib (2 μM) or the synergistic action of these two drugs. The cells without treatment acted as control. Cell proliferation, apoptosis and invasion were measured by bromodeoxyuridine assay, flow cytometry and modified Boyden chamber, respectively. Simultaneously, both modified Boyden chamber and scratch assay were used to assess cell migration. Finally, the phosphorylation levels of key kinases in the Akt/mechanistic target of rapamycin (mTOR)/mitogen-activated protein kinase (MAPK) pathway, and expression levels of matrix metalloproteinase (MMP)-2 and MMP-9 were detected by western blot analysis. Stimulation with IL-27 or sorafenib repressed proliferation, migration and invasion but promoted apoptosis, and the effects were all enhanced by the combination of these two drugs in HTB-9 cells. The effect of the combined treatment on bladder cancer cells was verified in T24 cells. Additionally, the phosphorylation levels of AKT, mTOR and MAPK as well as the expression levels of MMP-2 and MMP-9 were all decreased by a single treatment of IL-27 or sorafenib, and further decreased by the combined treatment of these two drugs. The combination of IL-27 and sorafenib inhibited proliferation, migration and invasion and promoted apoptosis of bladder cancer cells compared with mono-drug treatment. Additionally, the AKT/mTOR/MAPK pathway might be implicated in the functional effects by down-regulations of MMP-2 and MMP-9.
DOI: 10.6084/m9.figshare.7899116
title: Antineoplastic therapy administration: Nursing intervention in the relief of suffering

description: ABSTRACT Objective: To identify the nursing interventions with potential to act on the suffering and to evaluate the results of the nursing intervention designed. Method: We used a multi method study. After the identification of the scientific evidence and having found the supporting theory, the intervention process to relieve the suffering of hospitalized patients was modeled using the methodology of qualitative research. Then, training conditions were created for the implementation of the intervention Chemotherapy Administration as an Individualized Nursing Intervention, with a Quasi Experimental, longitudinal piloting study. Results: The patients of the experimental group showed values of suffering lower than the control group . Having finished the pilot study, we would return to qualitative research to understand the variation of some data. Final Considerations: The use of mixed methods of investigations allowed the understanding of the different components of drug chemotherapy administration as an individualized nursing intervention.
DOI: 10.6084/m9.figshare.7899119
title: The books of the dead revisited: mortality and morbidity in the German colonies of southern Brazil, 1850-1880

description: Abstract Examines mortality and morbidity in São Leopoldo/RS (1850-1880). Our interdisciplinary study is based on the Gemeindebücher (parish registers) produced by Lutheran communities. These “community books” reveal high rates of fertility and premature death. Infant mortality and maternal death assailed everyday life. Over half of all deaths were of infants and children. Of ten funerals, seven were for children and adults of reproductive and military age. This article contributes to debates over environmental, social and political determinants of mortality and people’s arts of living and healing in proto-statistical Brazil.
DOI: 10.6084/m9.figshare.7899122.v1
title: Long-term efficacy of a rural community-based integrated intervention for prevention and management of chronic obstructive pulmonary disease: a cluster randomized controlled trial in China's rural areas

description: This study aimed to assess the efficacy of a rural community-based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China. This 18-year cluster-randomized controlled trial encompassing 15 villages included 1008 patients (454 men and 40 women in the intervention group [mean age, 54 ± 10 years]; 482 men and 32 women in the control group [mean age, 53 ± 10 years]) with confirmed COPD or at risk for COPD. Villages were randomly assigned to the intervention or the control group, and study participants residing within the villages received treatment accordingly. Intervention group patients took part in a program that included systematic health education, smoking cessation counseling, and education on management of COPD. Control group patients received usual care. The groups were compared after 18 years regarding the incidence of COPD, decline in lung function, and mortality of COPD. COPD incidence was lower in the intervention group than in the control group (10% vs 16%, &lt;0.05). A decline in lung function was also significantly delayed in the intervention group compared to the control group of COPD and high-risk patients. The intervention group showed significant improvement in smoking cessation compared with the control group, and smokers in the intervention group had lower smoking indices than in the control group (350 vs 450, &lt;0.05). The intervention group also had a significantly lower cumulative COPD-related death rate than the control group (37% vs 47%, &lt;0.05). A rural community-based integrated intervention is effective in reducing the incidence of COPD among those at risk, delaying a decline in lung function in COPD patients and those at risk, and reducing mortality of COPD.