cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48717/exb2-y445
title: EVN Experiment N21C2
DOI: 10.48717/s99b-qp08
title: EVN Observation EC071L
DOI: 10.48717/ghad-9x87
title: EVN Observation EN007C
DOI: 10.48717/y80w-r763
title: EVN Experiment EN007
DOI: 10.48717/g6q0-1844
title: EVN Observation EF029A
DOI: 10.48717/vd7y-bf69
title: EVN Observation EM154
DOI: 10.48717/x9bt-tt29
title: EVN Experiment EM154
DOI: 10.48717/d77s-fw92
title: EVN Observation N21K2
DOI: 10.48717/fhwc-yg14
title: EVN Experiment N21K2
DOI: 10.48717/bf0k-qn74
title: EVN Observation EC077A
DOI: 10.48717/y0dz-ea16
title: EVN Observation EM144C
DOI: 10.48717/y0rm-hd58
title: EVN Experiment EM144
DOI: 10.48717/v750-4g69
title: EVN Observation ES095B
DOI: 10.48717/th36-yq69
title: EVN Observation EC071M
DOI: 10.48717/2bjf-z522
title: EVN Observation ES099B
DOI: 10.48717/yjf3-kp37
title: EVN Observation EM153A
DOI: 10.48717/5m6j-r304
title: EVN Observation EM152
DOI: 10.48717/ejxc-ms07
title: EVN Experiment EM152
DOI: 10.48717/zn7m-7a28
title: EVN Observation EC077D
DOI: 10.3886/e239580
title: HIFLD OPEN Mooring Facility Areas (USACE IENC)

description: The USACE IENCs coverage area consists of 7,260 miles across 21 rivers primarily located in the Central United States. IENCs apply to inland waterways that are maintained for navigation by USACE for shallow-draft vessels (e.g., maintained at a depth of 9-14 feet, dependent upon the waterway project authorization). Generally, IENCs are produced for those commercially navigable waterways which the National Oceanic and Atmospheric Administration (NOAA) does not produce Electronic Navigational Charts (ENCs). However, Special Purpose IENCs may be produced in agreement with NOAA.
description: Archived from the HIFLD Open GIS data repository, which was deactivated on August 26, 2025. (Downloaded 08/26)
DOI: 10.48717/bnpq-5j12
title: EVN Observation EC077C
DOI: 10.48717/rvy8-c771
title: EVN Observation ES099A
DOI: 10.3886/e239580v1
title: HIFLD OPEN Mooring Facility Areas (USACE IENC)

description: The USACE IENCs coverage area consists of 7,260 miles across 21 rivers primarily located in the Central United States. IENCs apply to inland waterways that are maintained for navigation by USACE for shallow-draft vessels (e.g., maintained at a depth of 9-14 feet, dependent upon the waterway project authorization). Generally, IENCs are produced for those commercially navigable waterways which the National Oceanic and Atmospheric Administration (NOAA) does not produce Electronic Navigational Charts (ENCs). However, Special Purpose IENCs may be produced in agreement with NOAA.
description: Archived from the HIFLD Open GIS data repository, which was deactivated on August 26, 2025. (Downloaded 08/26)
DOI: 10.48717/a6wd-m737
title: EVN Experiment ES099
DOI: 10.48717/h5zs-tb55
title: EVN Observation N21L2
DOI: 10.48717/hyxx-ay37
title: EVN Experiment N21L2
DOI: 10.48717/rmv5-5q78
title: EVN Observation EM153B
DOI: 10.48717/ykf8-p733
title: EVN Experiment EM153
DOI: 10.48717/7xw4-dc71
title: EVN Experiment EM149
DOI: 10.48717/s26x-r809
title: EVN Observation EM149
DOI: 10.48717/fprj-7410
title: EVN Observation EG116B
DOI: 10.48717/jd8x-5x86
title: EVN Experiment EG116
DOI: 10.48717/0h8k-h655
title: EVN Observation GM076
DOI: 10.48717/sd29-yw65
title: EVN Experiment GM076
DOI: 10.48717/2tcx-j072
title: EVN Observation ES095A
DOI: 10.48717/w9my-mb94
title: EVN Experiment ES095
DOI: 10.48717/vpmv-kt03
title: EVN Observation EC071N
DOI: 10.25318/3510021201-eng
title: Victims of police-reported violent crime, by gender of victim, type of violation, province or territory and census metropolitan area

description: Victims of police-reported violent crime, by gender of victim, type of violation, province or territory and census metropolitan area, 2009 to 2024.
DOI: 10.48717/fzv2-6k34
title: EVN Experiment EC071
DOI: 10.48717/2wnm-h233
title: EVN Observation EM150
DOI: 10.48717/9xss-k829
title: EVN Experiment EM150
DOI: 10.15468/dl.f9tatt
title: Occurrence Download

description: A dataset containing 2442 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is The Portneuf-sur-Mer Salt Marsh - Characterization of Important Coastal Habitats on the North Shore of the St. Lawrence Estuary | Le marais salé de Portneuf-sur-Mer - Caractérisation des habitats littoraux d’importance de la rive nord de l’estuaire maritime du Saint-Laurent"
 ]
}

 The dataset includes 2442 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013294-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/9f0r-cb47
title: EVN Experiment EC077
DOI: 10.48717/vx2p-zj42
title: EVN Observation EC077B
DOI: 10.48717/pjaf-5t77
title: EVN Experiment ES098
DOI: 10.48717/wkqa-kh96
title: EVN Observation ES098A
DOI: 10.48717/vjvd-xa63
title: EVN Observation EF029B
DOI: 10.48717/4x8g-6p96
title: EVN Experiment EF029
DOI: 10.15468/dl.bqsd44
title: Occurrence Download

description: A dataset containing 352 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Oman",
 "Year is 2017",
 "InstitutionCode is iNaturalist"
 ]
}

 The dataset includes 352 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013295-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/vj45-e811
title: EVN Observation EM146
DOI: 10.48717/ap0f-kn04
title: EVN Experiment EM146
DOI: 10.48717/rgkf-2b71
title: EVN Observation ES100B
DOI: 10.48717/tyac-bw80
title: EVN Observation EO018B
DOI: 10.48717/mr73-9z79
title: EVN Experiment EO018
DOI: 10.48717/x6nr-zy67
title: EVN Observation RP033
DOI: 10.48717/f5hn-5m81
title: EVN Experiment RP033
DOI: 10.48717/gqfj-6n42
title: EVN Experiment EK048
DOI: 10.48717/xw3r-3g71
title: EVN Observation EK048G
DOI: 10.48717/ad03-t240
title: EVN Observation RG012B
DOI: 10.48717/64nx-hd65
title: EVN Observation RG012A
DOI: 10.48717/gk3p-rs85
title: EVN Observation RG012D
DOI: 10.48717/qf7e-ky42
title: EVN Observation RG012C
DOI: 10.48717/ncar-rr07
title: EVN Observation RG012E
DOI: 10.48717/27nh-2888
title: EVN Observation RG012F
DOI: 10.15468/dl.tdxmjz
title: Occurrence Download

description: A dataset containing 475970 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vulpes vulpes",
 "HasCoordinate is true",
 "Country is Spain"
 ]
}

 The dataset includes 475970 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013252-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/62xv-zx47
title: EVN Observation EN010A
DOI: 10.48717/bg4n-2j33
title: EVN Observation EM156A
DOI: 10.48717/118d-mm21
title: EVN Observation EV023
DOI: 10.48717/x0bc-a096
title: EVN Experiment EV023
DOI: 10.48717/zatz-q389
title: EVN Observation EA065A
DOI: 10.48717/nxg1-cc89
title: EVN Observation RG012G
DOI: 10.48717/4rte-k203
title: EVN Observation RG012H
DOI: 10.15468/dl.qrt5kv
title: Occurrence Download

description: A dataset containing 152 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Argentina",
 "TaxonKey is Salmonopuntia salmiana"
 ]
}

 The dataset includes 152 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013297-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/fzs7-4626
title: EVN Observation RG012I
DOI: 10.48717/y0mx-d262
title: EVN Observation ES100C
DOI: 10.48717/ymv1-ry81
title: EVN Experiment ES100
DOI: 10.48717/tr9v-2a77
title: EVN Observation RG012J
DOI: 10.48717/aszj-j230
title: EVN Experiment RG012
DOI: 10.48717/5zrg-e810
title: EVN Observation EN010B
DOI: 10.48717/rvfn-w102
title: EVN Observation GP058B
DOI: 10.48717/7web-k084
title: EVN Observation EH039B
DOI: 10.48717/t32x-1946
title: EVN Observation EB085B
DOI: 10.48717/yxx3-pf37
title: EVN Experiment EB085
DOI: 10.48717/136e-gm02
title: EVN Observation N21M1
DOI: 10.48717/5gyj-wc88
title: EVN Experiment N21M1
DOI: 10.48717/gc7y-mp09
title: EVN Observation EB090B
DOI: 10.48717/h0ve-nz94
title: EVN Observation EN009A
DOI: 10.48717/b0dq-5346
title: EVN Observation EG118B
DOI: 10.15468/dl.pg7vhq
title: Occurrence Download

description: A dataset containing 31464 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vulpes vulpes",
 "HasCoordinate is true",
 "Country is Sweden"
 ]
}

 The dataset includes 31464 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013298-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/e2pz-5r28
title: EVN Observation EW025A
DOI: 10.48717/agtd-7v64
title: EVN Observation EH039C
DOI: 10.48717/z1cn-d920
title: EVN Observation N21C3
DOI: 10.48717/d4zj-9m72
title: EVN Experiment N21C3
DOI: 10.48717/1e6t-r256
title: EVN Experiment EM145
DOI: 10.48717/wzr8-xx38
title: EVN Observation EM145B
DOI: 10.48717/jnbz-px88
title: EVN Observation N21Q1
DOI: 10.48717/xax9-9m52
title: EVN Experiment N21Q1
DOI: 10.48717/3zzb-3s57
title: EVN Experiment N21K3
DOI: 10.48717/t56y-sr43
title: EVN Observation N21K3
DOI: 10.48717/8ekz-4m13
title: EVN Experiment EB087
DOI: 10.48717/r5sf-4c10
title: EVN Observation EB087
DOI: 10.48717/5xqz-rc82
title: EVN Observation EB090A
DOI: 10.48717/n9ds-nw46
title: EVN Experiment EB090
DOI: 10.48717/8fb5-9833
title: EVN Observation EN009B
DOI: 10.48717/qcyp-3e74
title: EVN Experiment EN009
DOI: 10.48717/vmnk-a876
title: EVN Observation EG118A
DOI: 10.48717/cg7e-xt77
title: EVN Experiment EG118
DOI: 10.48717/f095-wv05
title: EVN Observation EW025B
DOI: 10.48717/f3jz-d268
title: EVN Experiment EW025
DOI: 10.48717/rnxh-jg04
title: EVN Observation N21L3
DOI: 10.48717/bxrp-js33
title: EVN Experiment N21L3
DOI: 10.48717/5gpd-6771
title: EVN Observation EM157
DOI: 10.48717/k80j-6359
title: EVN Experiment EM157
DOI: 10.48717/vwc1-2n84
title: EVN Observation EB088
DOI: 10.48717/hfea-2232
title: EVN Experiment EB088
DOI: 10.48717/5y09-es09
title: EVN Observation ED049
DOI: 10.48717/j8nn-tt70
title: EVN Experiment ED049
DOI: 10.48717/npqw-jn78
title: EVN Observation EB089A
DOI: 10.48717/adt4-xz34
title: EVN Observation N21X2
DOI: 10.48717/ts0w-r142
title: EVN Experiment N21X2
DOI: 10.48717/8ark-zv74
title: EVN Observation RY009
DOI: 10.48717/ek43-jw86
title: EVN Experiment RY009
DOI: 10.48717/sw87-y721
title: EVN Observation GP058A
DOI: 10.48717/x4dq-3865
title: EVN Experiment GP058
DOI: 10.48717/d456-3957
title: EVN Experiment EH039
DOI: 10.48717/h3qj-h817
title: EVN Observation EH039A
DOI: 10.48717/9yx5-jy05
title: EVN Observation EM156B
DOI: 10.48717/gx10-7024
title: EVN Observation EK050A
DOI: 10.48717/t4w9-sq95
title: EVN Observation EN010C
DOI: 10.48717/f2dj-n966
title: EVN Observation EA065B
DOI: 10.48717/tcp7-9v20
title: EVN Observation EK050B
DOI: 10.7910/dvn/ltfvbg
title: Dave Leip Governor County Election Data

description: Governor General and Precinct County Election Data for years 1990 through 2024.
description: The data is only available to Harvard affiliates with a current Harvard ID and Key. 

If you are not affiliated with Harvard, you can request that your library or institution purchase the data from Dave Leip directly: https://uselectionatlas.org/
DOI: 10.48717/m180-1b18
title: EVN Observation EA065C
DOI: 10.48717/303b-sc37
title: EVN Observation EJ024
DOI: 10.48717/txss-rw76
title: EVN Experiment EJ024
DOI: 10.48717/6hek-cp71
title: EVN Observation EN010D
DOI: 10.48717/b3kg-xe83
title: EVN Experiment EN010
DOI: 10.48717/shdp-az04
title: EVN Observation FT043
DOI: 10.48717/4rc3-3r74
title: EVN Experiment FT043
DOI: 10.15468/dl.3pwx4d
title: Occurrence Download

description: A dataset containing 768 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Oman",
 "Year is 2018",
 "InstitutionCode is iNaturalist"
 ]
}

 The dataset includes 768 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013300-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/ta84-en03
title: EVN Observation EM160
DOI: 10.48717/r47c-gb42
title: EVN Experiment EM160
DOI: 10.48717/twez-2d06
title: EVN Observation EY039
DOI: 10.48717/hxaq-3c48
title: EVN Experiment EY039
DOI: 10.48717/rfr9-x615
title: EVN Observation RS003
DOI: 10.48717/69b1-ey37
title: EVN Experiment RS003
DOI: 10.48717/mb3b-ep94
title: EVN Observation EC082A
DOI: 10.48717/yeyb-j658
title: EVN Observation EC082B
DOI: 10.48717/5q6h-dm50
title: EVN Observation EA065D
DOI: 10.48717/d7we-yx13
title: EVN Observation EN011A
DOI: 10.48717/0r8p-ft60
title: EVN Observation EW022B
DOI: 10.48717/k6vm-1c33
title: EVN Observation N22Q1
DOI: 10.48717/sh5b-9767
title: EVN Experiment N22Q1
DOI: 10.48717/1s7p-sc46
title: EVN Observation N22L1
DOI: 10.48717/1qwt-e302
title: EVN Experiment N22L1
DOI: 10.48717/zwb9-de51
title: EVN Observation EB089B
DOI: 10.48717/bbpw-6504
title: EVN Observation ES101B
DOI: 10.48717/j3n6-7a97
title: EVN Observation EM161B
DOI: 10.48717/68es-nm52
title: EVN Observation EG113A
DOI: 10.48717/m9j7-t890
title: EVN Observation EC083A
DOI: 10.48717/vjvv-hw57
title: EVN Observation EH040A
DOI: 10.48717/p2qz-6106
title: EVN Observation EM155B
DOI: 10.48717/d0qf-mg27
title: EVN Observation EB086A
DOI: 10.48717/7m4x-de22
title: EVN Observation RA005
DOI: 10.48717/ajfk-zm59
title: EVN Experiment RA005
DOI: 10.48717/2g4v-t831
title: EVN Observation ER052A
DOI: 10.48717/py07-k612
title: EVN Observation ET048A
DOI: 10.48717/02ht-3a39
title: EVN Observation EG110B
DOI: 10.48717/bkx5-4r25
title: EVN Observation ER052B
DOI: 10.48717/gs73-d037
title: EVN Experiment ER052
DOI: 10.48717/8cqa-9y53
title: EVN Observation ET048B
DOI: 10.48717/0tek-ny52
title: EVN Experiment N22C1
DOI: 10.48717/c9b6-7x35
title: EVN Observation N22C1
DOI: 10.48717/4y4k-zt68
title: EVN Observation EG110A
DOI: 10.48717/h5rg-1464
title: EVN Experiment EG110
DOI: 10.48717/3908-v237
title: EVN Observation EH040B
DOI: 10.48717/g841-tq61
title: EVN Experiment EH040
DOI: 10.48717/fbfg-4346
title: EVN Observation EC083B
DOI: 10.48717/jnza-b572
title: EVN Observation EM155A
DOI: 10.48717/pjb5-xw23
title: EVN Experiment EM155
DOI: 10.48717/skwr-m557
title: EVN Observation EB086B
DOI: 10.48717/8xh3-f847
title: EVN Experiment EB086
DOI: 10.48717/511d-8685
title: EVN Observation EB091A
DOI: 10.48717/cw41-hz32
title: EVN Observation ES101A
DOI: 10.48717/xbrp-qr85
title: EVN Experiment ES101
DOI: 10.48717/fb6m-xf65
title: EVN Observation EO019
DOI: 10.48717/emq7-2z33
title: EVN Observation EG113B
DOI: 10.48717/sz3f-v747
title: EVN Experiment EG113
DOI: 10.48717/dbze-d755
title: EVN Experiment ET048
DOI: 10.48717/h048-x895
title: EVN Observation ET048C
DOI: 10.25574/29302
title: Chandra X-ray Observatory ObsId 29302

description: Calibration of the quasar Hubble diagram with z &lt;~ 0.7 quasars as CATs
DOI: 10.48717/v5s6-s282
title: EVN Observation EM161A
DOI: 10.48717/2fbf-d248
title: EVN Experiment EM161
DOI: 10.48717/xn6g-sn13
title: EVN Observation GM079
DOI: 10.48717/2fzt-v239
title: EVN Experiment GM079
DOI: 10.48717/ze70-as54
title: EVN Observation RSW02
DOI: 10.15468/dl.vttqr6
title: Occurrence Download

description: A dataset containing 5154 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vulpes vulpes",
 "HasCoordinate is true",
 "Country is Poland"
 ]
}

 The dataset includes 5154 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013302-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/bjbp-0t90
title: EVN Experiment RSW02
DOI: 10.48717/nysz-zd78
title: EVN Experiment EW022
DOI: 10.48717/xj2r-hd26
title: EVN Observation EW022A
DOI: 10.48717/xdnc-rg77
title: EVN Observation EA065E
DOI: 10.48717/dvvy-3j20
title: EVN Observation EC083C
DOI: 10.48717/ja9g-8741
title: EVN Observation EC083D
DOI: 10.48717/76zn-mm10
title: EVN Experiment EC083
DOI: 10.48717/0rhy-0k32
title: EVN Observation EV024A
DOI: 10.48717/9k7s-jd94
title: EVN Observation EA065F
DOI: 10.48717/j9kn-6293
title: EVN Observation RM017A
DOI: 10.48717/6wva-kz73
title: EVN Observation EK050C
DOI: 10.48717/ndv2-f945
title: EVN Observation EC082C
DOI: 10.15468/dl.q8xabu
title: Occurrence Download

description: A dataset containing 32607 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vulpes vulpes",
 "HasCoordinate is true",
 "Country is Norway"
 ]
}

 The dataset includes 32607 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013301-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/yn6t-hf58
title: EVN Observation EK050D
DOI: 10.48717/8rz2-mp48
title: EVN Experiment RSY08
DOI: 10.48717/ph6e-g324
title: EVN Observation RSY08
DOI: 10.48717/fxkb-a666
title: EVN Observation EA065G
DOI: 10.48717/c0b7-wp77
title: EVN Observation EC082D
DOI: 10.48717/qfme-jw70
title: EVN Observation EM162A
DOI: 10.48717/x91j-v185
title: EVN Experiment EM162
DOI: 10.48717/ztsv-tf71
title: EVN Observation EK050E
DOI: 10.48717/7zw3-p145
title: EVN Observation EB096A
DOI: 10.48717/qxqg-bg73
title: EVN Observation EV024B
DOI: 10.48717/ek1w-3405
title: EVN Observation EK050F
DOI: 10.48717/4037-zj97
title: EVN Observation GM081B
DOI: 10.48717/hv12-hr68
title: EVN Observation EC084B
DOI: 10.48717/xvz6-1w17
title: EVN Observation EG111B
DOI: 10.48717/knwe-h938
title: EVN Observation EB091B
DOI: 10.48717/b7qe-fv13
title: EVN Observation EC073A
DOI: 10.48717/7y3a-q881
title: EVN Observation EB096G
DOI: 10.48717/1jes-wn40
title: EVN Observation EC086A
DOI: 10.48717/7wc5-mn13
title: EVN Observation EG111D
DOI: 10.48717/zp46-5204
title: EVN Observation EG111C
DOI: 10.48717/zknv-qq51
title: EVN Observation GM081C
DOI: 10.48717/a7sg-xt02
title: EVN Observation ED050A
DOI: 10.25318/3510021201-fra
title: Victimes de crimes violents, affaires déclarées par la police, selon le genre de la victime, le type d’infraction, la province ou le territoire et la région métropolitaine de recensement

description: Victimes de crimes violents, affaires déclarées par la police, selon le genre de la victime, le type d’infraction, la province ou le territoire et la région métropolitaine de recensement, 2009 à 2024.
DOI: 10.15468/dl.47kafm
title: Occurrence Download

description: A dataset containing 984 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Oman",
 "Year is 2019",
 "InstitutionCode is iNaturalist"
 ]
}

 The dataset includes 984 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013303-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48717/fd97-7380
title: EVN Observation EW029A
DOI: 10.48717/e25j-db02
title: EVN Observation N22C2
DOI: 10.6084/m9.figshare.30113305
title: Supplemental Files for Sall1 fertility study

description: SALL1 is a critical regulator of embryonic development across a wide swath of tissues, including vital organs, but little is known about its function in adult tissues. Recent work from our group demonstrates that SALL1 is involved in urogenital development. This study delineates the role of SALL1 transcription factor in the adult reproductive system by demonstrating its requirement at multiple levels of uterine function during the implantation phase of early pregnancy. By generating a conditional knockout mouse model of <i>Sall1</i> exclusively in female reproductive organs, it is demonstrated herein that SALL1 is independently required both in the uterine luminal epithelium for the attachment of competent blastocysts to the uterine wall, as well as in the uterine stroma for the process of decidualization, another prerequisite for pregnancy success. This robust, multi-tissue-layer requirement for SALL1 across multiple stages in the process of implantation makes it a newly identified regulator of early pregnancy. Herein it is shown that loss of SALL1 causes misexpression of estrogen receptor alpha (ESR1) during the window of implantation, and subsequent pathological deregulation of multiple estrogen response genes whose tight titrations are prerequisites of pregnancy. RNA sequencing of independent knockout uterine compartments at multiple timepoints, and ChIP sequencing to identify direct transcriptional targets, elucidated multiple powerful regulatory pathways downstream of SALL1. Importantly, the use of a selective estrogen receptor antagonist, fulvestrant, at a precise timepoint and dose, offers a partial rescue of embryo attachment to the uterine luminal epithelium, further demonstrating that SALL1 is upstream of ESR1 during implantation phase signaling.
DOI: 10.6084/m9.figshare.30113305.v1
title: Supplemental Files for Sall1 fertility study

description: SALL1 is a critical regulator of embryonic development across a wide swath of tissues, including vital organs, but little is known about its function in adult tissues. Recent work from our group demonstrates that SALL1 is involved in urogenital development. This study delineates the role of SALL1 transcription factor in the adult reproductive system by demonstrating its requirement at multiple levels of uterine function during the implantation phase of early pregnancy. By generating a conditional knockout mouse model of <i>Sall1</i> exclusively in female reproductive organs, it is demonstrated herein that SALL1 is independently required both in the uterine luminal epithelium for the attachment of competent blastocysts to the uterine wall, as well as in the uterine stroma for the process of decidualization, another prerequisite for pregnancy success. This robust, multi-tissue-layer requirement for SALL1 across multiple stages in the process of implantation makes it a newly identified regulator of early pregnancy. Herein it is shown that loss of SALL1 causes misexpression of estrogen receptor alpha (ESR1) during the window of implantation, and subsequent pathological deregulation of multiple estrogen response genes whose tight titrations are prerequisites of pregnancy. RNA sequencing of independent knockout uterine compartments at multiple timepoints, and ChIP sequencing to identify direct transcriptional targets, elucidated multiple powerful regulatory pathways downstream of SALL1. Importantly, the use of a selective estrogen receptor antagonist, fulvestrant, at a precise timepoint and dose, offers a partial rescue of embryo attachment to the uterine luminal epithelium, further demonstrating that SALL1 is upstream of ESR1 during implantation phase signaling.
DOI: 10.48717/z3wd-ps68
title: EVN Experiment N22C2
DOI: 10.48717/4y9c-x481
title: EVN Observation EB096F
DOI: 10.48717/1y80-rj63
title: EVN Experiment EB089
DOI: 10.48717/7g9s-w778
title: EVN Observation EB089C
DOI: 10.48717/b4db-7c50
title: EVN Observation EB096H