cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25469950
title: Supplementary Material for: Kidney failure secondary to hereditary xanthinuria due to a homozygous deletion of the XDH gene, in the absence of overt kidney stone disease

description: Hereditary xanthinuria (HXAN) is a rare metabolic disorder that results from mutations in either the xanthine dehydrogenase (XDH) or the molybdenum cofactor sulfurase genes (MOCOS), respectively defining HXAN type I and type II. Hypouricemia, hypouricosuria, and abnormally high plasma and urine levels of xanthine, causing susceptibility to xanthine nephrolithiasis and deposition of xanthine crystals in tissues, are the metabolic hallmarks of HXAN. Several pathogenic variants in the XDH gene have so far been identified in patients with HXAN type I, but the clinical phenotype associated with the whole deletion of the human XDH gene is unknown. Herein, we report the case of a woman diagnosed with HXAN, whose molecular genetic testing revealed a homozygous microdeletion involving the XDH gene. Distinctive features of her medical history were the diagnosis of arterial hypertension and microalbuminuria at 22 years of age; a single pregnancy, at the age of 25, complicated by proteinuria and transient kidney function deterioration in the third trimester; unexplained severe hypouricaemia incidentally discovered during pregnancy; inability to breastfeed her newborn daughter due to primary agalactia; chronic kidney disease (CKD) stage 3 diagnosed at age 35; and progression to end-stage kidney disease over the next 12 years. Protocol non-invasive laboratory and imaging investigation was not informative as to the cause of CKD. This is the first description of the clinical phenotype associated with a natural knockout of the human XDH gene. Despite the lack of kidney histopathology data, the striking similarities with the phenotypes exhibited by comparable murine models validates the latter as useful sources of mechanistic insights for the pathogenesis of the human disease, supporting the hypothesis that the absence of xanthine dehydrogenase activity might represent a susceptibility factor for chronic tubulointerstitial nephritis, even in patients without kidney stones.
DOI: 10.6084/m9.figshare.25956190
title: Supplementary Material for: Prevalence and Rapid Screen Method of Diagnostic Criteria for Psychosomatic Research Syndromes in Human Papillomavirus-Infected Patients

description: Introduction: The early and rapid identification of psychosomatic symptoms is crucial to prevent harmful outcomes in patients with human papillomavirus (HPV) infection in busy comprehensive clinics. Objective: This study aimed to explore the prevalence and rapid screening method of the Diagnostic Criteria for Psychosomatic Research-Revised (DCPR) syndromes in patients with HPV infection.
Methods: A total of 504 participants underwent a clinical assessment, that included DCPR, Diagnostic and Statistical Manual of Mental (DSM)-5, the Social Support Rating scale (SSRS), the Simplified Coping Style Questionnaire (SCSQ), fear of disease, sociodemographic, and clinical characteristics. We compared the prevalence of DCPR syndromes and DSM-5 diagnoses between the HPV-positive and negative patients using Kruskal‒Wallis tests. We explored the rapid screen indicator through multiple logistic regression analyses of the participants’ psychosocial fators, sociodemographic and clinical characteristics.
Results: The incidence of DCPR syndromes in HPV-positive patients (56.6%) was significantly greater than that in HPV-negative patients (17.3%) and DSM-5 diagnoses (8.5%) in the HPV positive group. As the degree of fear increased from 0 to 5 to 10, the risk of DCPR increased from 1.27 (95% CI: 0.21-7.63) to 3.24 (score range: 1–5, 95% CI: 1.01–10.39) to 9.91 (score range: 6–10, 95% CI: 3.21–30.62) in the HPV-positive group.
Conclusions: Health anxiety, irritable mood, type A behavior and demoralization were the most common psychosomatic syndromes in HPV-positive patients. The degree of fear, as an independent risk factor, could be used to quickly screen outpatients with a high risk of DCPR syndrome among women with HPV infection.
DOI: 10.6084/m9.figshare.26403028
title: Supplementary Material for: Negative prognostic associations of selective serotonin reuptake inhibitors use in hospitalized COVID-19 patients and potential contribution of cardiovascular comorbidities

description: Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative agent of Coronavirus disease 2019 (COVID-19), a very contagious systemic disease dominantly affecting the respiratory tract. Recent findings oppose earlier suggestions that selective serotonin reuptake inhibitors (SSRI) might be protective during acute SARS-CoV-2 infection, prompting the current study. 
Patients and methods: The institutional registry of a tertiary referral center was retrospectively evaluated for SSRI use and associated clinical outcomes among hospitalized COVID-19 patients with mostly severe and critical disease. 
Results: Among 1558 patients, there were 78 (5%) exposed to SSRI during hospitalization. SSRI users in comparison to non-users did not significantly differ in their demographic characteristics, comorbidity profile or the severity of COVID-19 symptoms and associated inflammatory response at admission. In multivariate analyses adjusted for clinically meaningful variables, SSRI use was significantly associated with higher risks of death, mechanical ventilation, intensive care unit treatment, and bacteremia, whereas no significant relationship with risks of venous, arterial thrombosis, and major bleeding was present. Patients with less severe initial COVID-19 presentation, lower inflammatory burden, higher platelet count, lower cumulative comorbidity burden, presence of hyperlipidemia, atrial fibrillation, chronic heart failure and non-exposed to acetylsalicylic-acid had higher mortality associated with SSRI use. 
Conclusions: Findings of the current study validate findings of higher mortality but also report higher tendency for respiratory deterioration, intensive care unit treatment, and bacteremia associated with SSRI use among hospitalized COVID-19 patients. These findings also suggest the potential contribution of cardiovascular comorbidities to detrimental clinical course of SSRI exposed patients.
DOI: 10.6084/m9.figshare.26411857
title: Supplementary Material for: Extraskeletal Ewing sarcoma of the extremities and trunk: a retrospective analysis of a mono-institutional series

description: Introduction Extra-skeletal Ewing sarcoma is a rare malignant tumor, and current international recommendations indicate systemic and local treatment like bone Ewing sarcoma; to the best of our knowledge, very few studies tried to explore the clinical and genetic characteristics of this tumor and the most appropriate treatment strategy remains uncertain. 
Methods We reviewed 35 extra-skeletal Ewing sarcoma (EEwS) cases enrolled at Rizzoli Orthopedic Institute in Bologna, Italy between 1988-2022. We performed RNA sequencing in 18 Ewing sarcoma cases, including 12 bone Ewing sarcomas (BEwS) and 6 EEwS. We analyzed overall survival (OS), local relapse-free survival (LRFS), and metastasis-free survival (MFS) and the risk factors associated to survival.
Results Unsupervised Hierarchical clustering showed no differences in the transcriptional profile between EEwS and BEwS. Five-year OS was 67% (95%CI 47-80), 5-year LRFS was 61% (95% CI 43-75), and 5-year MFS was 55% (95% CI 38-70). Recurrent tumors, larger than 8 cm, and elevated LDH serum value resulted to be a negative prognostic factor.
Conclusions The founding of a genetic profile indistinguishable between EEwS and BEwS, confirms the view that includes the two subgroups in the same tumor entity and supports the use of a single therapeutic approach for Ewing sarcoma independently from the site of origin. Statistical evaluation showed that size bigger than 8cm, elevated LDH, and recurrent tumors had a worse prognosis, suggesting a risk-stratification method for identifying patients for specific therapy treatment. However, larger, multicentre, prospective trials are called for to validate our findings.
DOI: 10.6084/m9.figshare.26414047
title: Supplementary Material for: Dual-task performance and brain morphologic characteristics in Parkinson’s disease.

description: Introduction
Parkinson’s disease (PD) reduces an individual's capacity for automaticity which limits their ability to perform two tasks simultaneously, negatively impacting daily function. Understanding the neural correlates of dual-tasks (DT) may pave the way for targeted therapies. To better understand automaticity in PD, we aimed to explore whether individuals with differing DT performances possessed differences in brain morphologic characteristics.
Methods
Data were obtained from 34 individuals with PD and 47 healthy older adults including: 1) demographics (age, sex), 2) disease severity (Movement Disorder Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Hoehn & Yahr, levodopa equivalent daily dose (LEDD)), 3) cognition (Montreal Cognitive Assessment), 4) Levodopa Equivalent Daily Dose, 5) single task- and DT- performance during a DT-Timed-Up-and-Go test utilizing a serial-subtraction task, and 6) Cortical thicknesses and subcortical volumes obtained from volumetric MRI. Participants were categorized as low or high DT performers if their combined DT-effect was greater than the previously determined mean value for healthy older adults (μ=74.2). Nonparametric testing using Quade’s ANCOVA was conducted to compare cortical thicknesses and brain volumes between the highDT and lowDT groups while controlling for covariates: age, sex, MDS-UPDRS part III, LEDD, and intracranial volume. Secondarily, similar comparisons were made between the healthy older adult group the highDT and lowDT groups. Lastly, a hierarchical linear regression model was conducted regressing combined DT-effect on covariates (block one) and cortical thicknesses (block 2) in stepwise fashion.
Results
The highDT group had thicker cortices than the lowDT group in the right primary somatosensory (p=0.001), bilateral primary motor (p=&lt;0.001, left; p=0.002, right), bilateral supplementary motor area (p=0.001, left; p&lt;0.001, right), and mean of the bilateral hemispheres (p=0.001, left; p&lt;0.001, right). Of note, left primary cortex thickness (p=0.002), left prefrontal cortex thickness (p&lt;0.001), and right supplementary motor area thickness (p=0.003) differed when adding a healthy comparison group. Additionally, the regression analysis found that the left paracentral lobule thickness explained 20.8% of the variability in combined DT-effect (p=0.011) beyond the influence of covariates. 
Conclusions
These results suggest regions underlying dual-task performance; specifically, a convergence of neural control relying sensorimotor integration, motor planning, and motor activation to achieve higher levels of DT performance for individuals with PD.
DOI: 10.6084/m9.figshare.25866631
title: Supplementary Material for: Emotional changes during Imagery Rescripting of aversive social memories in Social Anxiety Disorder: a randomized controlled trial

description: Introduction: Imagery Rescripting (ImRs) is a psychotherapeutic intervention targeting aversive memories. During the three-phase intervention, patients re-experience their aversive memory (phase 1), observe the scene from their adult perspective and intervene to help their former selves (phase 2), and re-experience it again with the positive changes (phase 3). Previous studies have rarely investigated emotional and regulatory processes taking place during the intervention.
Objective: This randomized-controlled trial investigated self-reported affective and physiological responses during ImRs.
Methods: Seventy-seven patients with Social Anxiety Disorder (SAD) were randomly assigned to a single session ImRs or a control intervention (recall and discussion of the memory) targeting an aversive social memory. Heart rate (HR) and heart rate variability (HRV) were assessed during and post-hoc ratings of positive and negative feelings after baseline and the intervention phases. 
Results: Relative to the control intervention, ImRs resulted in an initial increase in negative feelings from baseline to phase 1 and a following larger (phase 1 to phase 2) and more stable (phase 2 to phase 3) decrease in negative feelings/increase in positive feelings. On the physiological level, during ImRs compared to the control intervention, mean HR was significantly higher during phase 1 and HRV during phase 3, each compared to baseline.
Conclusions: These results provide further information about the specific sequence of emotional responses on different response levels during ImRs, being consistent with known theories of emotional processing and supposed mechanisms of ImRs.
DOI: 10.6084/m9.figshare.26411668
title: Supplementary Material for: Impact of the COVID-19 Pandemic on Acute Stroke Rehabilitation in Japanese Primary Stroke Centers: A Nationwide Cross-Sectional Study Using a Web-based Questionnaire Survey

description: Introduction: Acute stroke rehabilitation is crucial for achieving good functional recovery, even during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to clarify the impact of the COVID-19 pandemic on acute stroke rehabilitation and identify which components in the acute stroke rehabilitation provision system were susceptible to the pandemic.
Methods: A web-based questionnaire survey was conducted in all primary stroke centers (PSCs) in Japan between February 7 and April 21, 2022. The survey included questions about the current status of acute stroke rehabilitation and the influence of the pandemic. We classified the influences and investigated the relationship between the influence of the pandemic and the provision of rehabilitation. Additionally, we investigated a group of prefectures divided according to the grade of the pandemic.
Results: The survey response rate was 67% (639 of 959 PSCs). Among them, 387 PSCs (61%) reported that the COVID-19 pandemic affected acute stroke rehabilitation. In PSCs affected by the pandemic, more rehabilitation-related staff were working, and the proportion of weekend/holiday rehabilitation implementation was higher compared to those unaffected. In PSCs from highly infected prefectures, no significant relationship was observed between the influence of the pandemic and the rehabilitation provision system.
Conclusions: PSCs that provide denser acute stroke rehabilitation may be affected to a greater extent by the pandemic. We conclude that stroke hospitals should formulate infection control procedures for acute stroke rehabilitation in advance, depending on the conditions of the region and facility.
DOI: 10.6084/m9.figshare.26412334
title: Supplementary Material for: Conventional excisional haemorrhoidectomy versus transanal haemorrhoidal dearterialization for haemorrhoids - a systematic review and meta-analysis

description: Introduction
Although effective, conventional excisional haemorrhoidectomy (CEH) may be associated with significant postoperative pain. Novel techniques such as transanal haemorrhoidal dearterialization (THD) are suggested to reduce pain, but may result in higher recurrence rates. We aimed to compare short and long-term outcomes of CEH and THD in the present meta-analysis.

Methods
A PRISMA-compliant meta-analysis was performed, searching PubMed, EMBASE and CENTRAL databases for randomized controlled trials (RCTs) from 1995 until December 2022. The primary objective was recurrence. Secondary objectives included complication rates, length of stay (LOS), operative time and time to return to baseline. Random-effects models were used to calculate pooled effect size estimates. Subgroup analysis was also performed.

Results
6 RCTs encompassing 465 patients were captured. There were 142 (59%) males in the CEH group and 129 (54%) in the THD group.. On random effects analysis, THD had a higher recurrence rate (OR = 2.76, 95% CI = 1.03 to 7.38, p = 0.04) albeit a shorter return to baseline comparative to CEH (MD = -14.05 days, 95% CI = -20.38 to -7.72, p &lt; 0.0001). There were no differences in bleeding (p = 0.12), urinary retention (p = 0.97), incontinence (p = 0.41), anal stenosis (p = 0.19), thrombosed residual haemorrhoids (p = 0.16), operating time (p = 0.19) or LOS (p = 0.22). Results remained similar on subgroup analysis.

Conclusions
CEH is associated with lower recurrence rates and no difference in complication rate to THD, although patients take longer to return to baseline function postoperatively.
DOI: 10.15468/dl.3y8vuz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073635-240626123714530/datasets/export for details.
DOI: 10.15468/dl.6tfwzy
title: Occurrence Download

description: A dataset containing 362927 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is USMB Insecta"
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}

 The dataset includes 362927 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073629-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9u7r5u
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073636-240626123714530/datasets/export for details.
DOI: 10.14278/rodare.2750
title: Source Data: Laser-driven high-energy proton beams from cascaded acceleration regimes

description: This dataset contains all source data used to generate figures and all other findings of the publication: "Laser-driven high-energy proton beams from cascaded acceleration regimes".
DOI: 10.14278/rodare.2749
title: Source Data: Laser-driven high-energy proton beams from cascaded acceleration regimes

description: This dataset contains all source data used to generate figures and all other findings of the publication: "Laser-driven high-energy proton beams from cascaded acceleration regimes".
DOI: 10.14278/rodare.2887
title: Source Data: Laser-driven high-energy proton beams from cascaded acceleration regimes

description: This dataset contains all source data used to generate figures and all other findings of the publication: "Laser-driven high-energy proton beams from cascaded acceleration regimes".
DOI: 10.15468/dl.y7j5vs
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is SDN",
 "TaxonKey is Ziziphus mauritiana Lam."
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}

 The dataset includes 17 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073637-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w8msws
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
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 The dataset includes 5 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073638-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.aum8hg
title: Occurrence Download

description: A dataset containing 8865 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Bidens bipinnata L."
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}

 The dataset includes 8865 records from 311 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073639-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.59fa6m
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Bhutan, India)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Rhododendron kendrickii Nutt."
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}

 The dataset includes 6 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073641-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pcs2vy
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073643-240626123714530/datasets/export for details.
DOI: 10.15468/dl.yb8uby
title: Occurrence Download

description: A dataset containing 84 species occurrences available in GBIF matching the query:
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 "and" : [
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 The dataset includes 84 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073645-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hnv8zj
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mozambique",
 "OccurrenceStatus is Present",
 "TaxonKey is Coffea schliebenii Bridson"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073646-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/9202055
title: ⏳ endoflife.date database (duckdb)
DOI: 10.15468/dl.tty7zp
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
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 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0073647-240626123714530/datasets/export for details.