cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20337308
title: Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives

description: Abstract In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= &lt; 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.
DOI: 10.6084/m9.figshare.20337311
title: Effect of a fungal glycoprotein on scab control caused by Cladosporium herbarum in passion fruit plants

description: Abstract Phytosanitary problems drastically affect passion fruit cultivation around the world. Scab, a fungal disease that attacks the aerial part of plants, especially the younger leaves, impairs development and reduces plant productivity. The objective of this work was to evaluate the effect of treatment with a fungal cell wall glycoprotein, named pGM from peptidogalactomanann, in the control scab caused by Cladosporium hebarum infection. Under greenhouse conditions, morphological parameters or plant development were evaluated in two passion fruit genotypes, ‘H09-110/111’ and ‘FB300’. pGM treatment was able to mitigate the damage caused to plant development in parameters such as height, the number of leaves, stem diameter, leaf area and biomass in the ‘H09-110/111’ genotype compared to the control. However, in the genotype ‘FB300’, no significant differences were observed concerning the control. Passion fruit scab disease incidence and severity were also reduced by pGM treatment. Therefore, this study suggests that the use of pGM can lead to control and attenuation of the damage caused by this fungus in the early stages of passion fruit plants ‘H09-110/111’ when the plants are more susceptible to biotic stresses.
DOI: 10.6084/m9.figshare.20337311.v1
title: Effect of a fungal glycoprotein on scab control caused by Cladosporium herbarum in passion fruit plants

description: Abstract Phytosanitary problems drastically affect passion fruit cultivation around the world. Scab, a fungal disease that attacks the aerial part of plants, especially the younger leaves, impairs development and reduces plant productivity. The objective of this work was to evaluate the effect of treatment with a fungal cell wall glycoprotein, named pGM from peptidogalactomanann, in the control scab caused by Cladosporium hebarum infection. Under greenhouse conditions, morphological parameters or plant development were evaluated in two passion fruit genotypes, ‘H09-110/111’ and ‘FB300’. pGM treatment was able to mitigate the damage caused to plant development in parameters such as height, the number of leaves, stem diameter, leaf area and biomass in the ‘H09-110/111’ genotype compared to the control. However, in the genotype ‘FB300’, no significant differences were observed concerning the control. Passion fruit scab disease incidence and severity were also reduced by pGM treatment. Therefore, this study suggests that the use of pGM can lead to control and attenuation of the damage caused by this fungus in the early stages of passion fruit plants ‘H09-110/111’ when the plants are more susceptible to biotic stresses.
DOI: 10.6084/m9.figshare.20337312.v1
title: Design of a specific peptide against phenolic glycolipid-1 from Mycobacterium leprae and its implications in leprosy bacilli entry

description: BACKGROUND Mycobacterium leprae, the causative agent of Hansen’s disease, causes neural damage through the specific interaction between the external phenolic glycolipid-1 (PGL-1) and laminin subunit alpha-2 (LAMA2) from Schwann cells. OBJECTIVE To design a LAMA2-based peptide that targets PGL-1 from M. leprae. METHODS We retrieved the protein sequence of human LAMA2 and designed a specific peptide using the Antimicrobial Peptide Database and physicochemical parameters for antimycobacterial peptide-lipid interactions. We used the AlphaFold2 server to predict its three-dimensional structure, AUTODOCK-VINA for docking, and GROMACS programs for molecular dynamics simulations. FINDINGS We analysed 52 candidate peptides from LAMA2, and subsequent screening resulted in a single 60-mer peptide. The mapped peptide comprises four β-sheets and a random coiled region. This peptide exhibits a 45% hydrophobic ratio, in which one-third covers the same surface. Molecular dynamics simulations show that our predicted peptide is stable in aqueous solution and remains stable upon interaction with PGL-1 binding. In addition, we found that PGL-1 has a preference for one of the two faces of the predicted peptide, which could act as the preferential binding site of PGL-1. MAIN CONCLUSIONS Our LAMA2-based peptide targeting PGL-1 might have the potential to specifically block this key molecule, suggesting that the preferential region of the peptide is involved in the initial contact during the attachment of leprosy bacilli to Schwann cells.
DOI: 10.6084/m9.figshare.20337312
title: Design of a specific peptide against phenolic glycolipid-1 from Mycobacterium leprae and its implications in leprosy bacilli entry

description: BACKGROUND Mycobacterium leprae, the causative agent of Hansen’s disease, causes neural damage through the specific interaction between the external phenolic glycolipid-1 (PGL-1) and laminin subunit alpha-2 (LAMA2) from Schwann cells. OBJECTIVE To design a LAMA2-based peptide that targets PGL-1 from M. leprae. METHODS We retrieved the protein sequence of human LAMA2 and designed a specific peptide using the Antimicrobial Peptide Database and physicochemical parameters for antimycobacterial peptide-lipid interactions. We used the AlphaFold2 server to predict its three-dimensional structure, AUTODOCK-VINA for docking, and GROMACS programs for molecular dynamics simulations. FINDINGS We analysed 52 candidate peptides from LAMA2, and subsequent screening resulted in a single 60-mer peptide. The mapped peptide comprises four β-sheets and a random coiled region. This peptide exhibits a 45% hydrophobic ratio, in which one-third covers the same surface. Molecular dynamics simulations show that our predicted peptide is stable in aqueous solution and remains stable upon interaction with PGL-1 binding. In addition, we found that PGL-1 has a preference for one of the two faces of the predicted peptide, which could act as the preferential binding site of PGL-1. MAIN CONCLUSIONS Our LAMA2-based peptide targeting PGL-1 might have the potential to specifically block this key molecule, suggesting that the preferential region of the peptide is involved in the initial contact during the attachment of leprosy bacilli to Schwann cells.
DOI: 10.6084/m9.figshare.20337318
title: EFFECT OF AEROBIC EXERCISE ON PHYSICAL FUNCTION INDICES IN THE ELDERLY

description: ABSTRACT Introduction China is currently experiencing the problem of population aging, and the health status of the elderly has become a major focus of social attention. Objective Study the effect of aerobic exercise on the indices of physical function in the elderly. Methods 40 elderly people performed aerobic exercise 5 times a week for 8 weeks. Each exercise lasted 60 minutes, including 10 minutes of warm-up, 40 minutes of aerobic exercise (running, brisk walking, square dancing, among other activities), and 10 minutes of final cool-down. Data measurement included body indices, cardiopulmonary function, blood markers, and exercise capacity. Results Aerobic exercise can effectively improve the body shape, cardiopulmonary function, and blood lipid content of the elderly, and improve their flexibility and physical quality, enhancing their activities of daily living. Conclusion The results of this study show that aerobic exercise can effectively improve the body performance of the elderly in activities of daily living, effectively optimizing cardiopulmonary and lipid indexes. Engaging the elderly to participate in aerobic exercise should be considered by community social workers. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.20337318.v1
title: EFFECT OF AEROBIC EXERCISE ON PHYSICAL FUNCTION INDICES IN THE ELDERLY

description: ABSTRACT Introduction China is currently experiencing the problem of population aging, and the health status of the elderly has become a major focus of social attention. Objective Study the effect of aerobic exercise on the indices of physical function in the elderly. Methods 40 elderly people performed aerobic exercise 5 times a week for 8 weeks. Each exercise lasted 60 minutes, including 10 minutes of warm-up, 40 minutes of aerobic exercise (running, brisk walking, square dancing, among other activities), and 10 minutes of final cool-down. Data measurement included body indices, cardiopulmonary function, blood markers, and exercise capacity. Results Aerobic exercise can effectively improve the body shape, cardiopulmonary function, and blood lipid content of the elderly, and improve their flexibility and physical quality, enhancing their activities of daily living. Conclusion The results of this study show that aerobic exercise can effectively improve the body performance of the elderly in activities of daily living, effectively optimizing cardiopulmonary and lipid indexes. Engaging the elderly to participate in aerobic exercise should be considered by community social workers. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.20337317
title: A BI-OBJECTIVE MULTIPERIOD ONE-DIMENSIONAL CUTTING STOCK PROBLEM

description: ABSTRACT In this paper, we investigate the bi-objective multiperiod one-dimensional cutting stock problem that seeks to minimize the cost of production associated with the total length of cut objects (waste) and the inventory costs related to objects and items. A mathematical model is presented and heuristically solved by a column generation method. Computational tests were performed using the Weighted Sum method, the ε-Constraint method and a variation of the Benson method. The Pearson correlation coefficient was calculated in order to investigate the trade-off between the conflicting objectives of the problem. The results confirmed a strong negative correlation between the objective functions of the problem. All the applied scalar methods were able to find multiple efficient solutions for the problem in a reasonable computational time; however, the ε-Constraint and the modified Benson methods performed better.
DOI: 10.6084/m9.figshare.20337317.v1
title: A BI-OBJECTIVE MULTIPERIOD ONE-DIMENSIONAL CUTTING STOCK PROBLEM

description: ABSTRACT In this paper, we investigate the bi-objective multiperiod one-dimensional cutting stock problem that seeks to minimize the cost of production associated with the total length of cut objects (waste) and the inventory costs related to objects and items. A mathematical model is presented and heuristically solved by a column generation method. Computational tests were performed using the Weighted Sum method, the ε-Constraint method and a variation of the Benson method. The Pearson correlation coefficient was calculated in order to investigate the trade-off between the conflicting objectives of the problem. The results confirmed a strong negative correlation between the objective functions of the problem. All the applied scalar methods were able to find multiple efficient solutions for the problem in a reasonable computational time; however, the ε-Constraint and the modified Benson methods performed better.
DOI: 10.6084/m9.figshare.20337321.v1
title: Profile of transversal skills of Nursing students to intervene in disaster situations

description: ABSTRACT Objective: to identify the profile of transversal teaching/learning skills, which allows an adequate intervention of disaster nursing students. Methods: this is research framed in the qualitative, transversal paradigm methodology, supported by inductive and exploratory reasoning. Results: it was found that there is no consensus between Nursing Education Major Coordinators/Directors and disaster nursing experts regarding transversal skills considered decisive, due to the current absence of the theme in study plans and the limited personal and professional training of professors. Final considerations: the development and implementation of teaching/learning strategies that allow the development of transversal skills, favoring students’ ability to meet this reality in a conscious, balanced and efficient way, is crucial.
DOI: 10.6084/m9.figshare.20337321
title: Profile of transversal skills of Nursing students to intervene in disaster situations

description: ABSTRACT Objective: to identify the profile of transversal teaching/learning skills, which allows an adequate intervention of disaster nursing students. Methods: this is research framed in the qualitative, transversal paradigm methodology, supported by inductive and exploratory reasoning. Results: it was found that there is no consensus between Nursing Education Major Coordinators/Directors and disaster nursing experts regarding transversal skills considered decisive, due to the current absence of the theme in study plans and the limited personal and professional training of professors. Final considerations: the development and implementation of teaching/learning strategies that allow the development of transversal skills, favoring students’ ability to meet this reality in a conscious, balanced and efficient way, is crucial.
DOI: 10.5281/zenodo.6860524
title: Rh-Catalyzed [3+2] Annulation of Cyclic Ketimines and Alkynylchloride: A Novel Strategy to Access Unsymmetrically Substituted and Highly Functionalizable Indenes

description: This zipped file is a set of original NMR data pre-uploaded to zenodo and will be linked with a scientific publication which is under peering review.
DOI: 10.5281/zenodo.6860523
title: Rh-Catalyzed [3+2] Annulation of Cyclic Ketimines and Alkynylchloride: A Novel Strategy to Access Unsymmetrically Substituted and Highly Functionalizable Indenes

description: This zipped file is a set of original NMR data pre-uploaded to zenodo and will be linked with a scientific publication which is under peering review.
DOI: 10.6084/m9.figshare.20337326.v1
title: PREVENTION AND REHABILITATION OF ANKLE SPRAIN IN SOCCER TRAINING

description: ABSTRACT Introduction In soccer training, many impacts in running and defense make ankle sprain a very common sports injury; therefore, prevention and rehabilitation management of ankle sprain is particularly important. Objective Explore the strategy of preventing and rehabilitating ankle sprain in soccer training. Methods 10 athletes with ankle sprain were selected and randomly divided into the experimental and control group. Both groups received rehabilitation training, the control group received only manual therapy, and the experimental group received active and passive rehabilitation management. The indices relevant to ankle rehabilitation were analyzed daily: active extension and flexion angle, in addition to the degree of joint edema. Results By the third day, the experimental group’s recovery rate was significantly higher. By the end of the seventh day, the active plantar flexion angle in the control group was 28.0133, while in the experimental group, it was 32.0512. As for the degree of joint swelling on day 5, the experimental group was 2.2059 and 1.0057 in the control group. The control group only achieved this level of recovery in the experimental group on the seventh day. Conclusion Using comparative analysis, the rehabilitation strategy associated with the active and passive techniques proposed in this article showed a better performance than the traditional protocol. Studies are suggested popularizing rehabilitation combined with active training with passive traction. Level of evidence II; Therapeutic studies - investigation of treatment results.
DOI: 10.6084/m9.figshare.20337326
title: PREVENTION AND REHABILITATION OF ANKLE SPRAIN IN SOCCER TRAINING

description: ABSTRACT Introduction In soccer training, many impacts in running and defense make ankle sprain a very common sports injury; therefore, prevention and rehabilitation management of ankle sprain is particularly important. Objective Explore the strategy of preventing and rehabilitating ankle sprain in soccer training. Methods 10 athletes with ankle sprain were selected and randomly divided into the experimental and control group. Both groups received rehabilitation training, the control group received only manual therapy, and the experimental group received active and passive rehabilitation management. The indices relevant to ankle rehabilitation were analyzed daily: active extension and flexion angle, in addition to the degree of joint edema. Results By the third day, the experimental group’s recovery rate was significantly higher. By the end of the seventh day, the active plantar flexion angle in the control group was 28.0133, while in the experimental group, it was 32.0512. As for the degree of joint swelling on day 5, the experimental group was 2.2059 and 1.0057 in the control group. The control group only achieved this level of recovery in the experimental group on the seventh day. Conclusion Using comparative analysis, the rehabilitation strategy associated with the active and passive techniques proposed in this article showed a better performance than the traditional protocol. Studies are suggested popularizing rehabilitation combined with active training with passive traction. Level of evidence II; Therapeutic studies - investigation of treatment results.
DOI: 10.6084/m9.figshare.20337327
title: A TYPOLOGY FOR MCDM METHODS BASED ON THE RATIONALITY OF THEIR PAIRWISE COMPARISON PROCEDURES

description: ABSTRACT MCDM methods have been proposed to select, rank, classify, or describe alternatives based on the process of pairwise comparison. While the typologies of MCDM methods present in the literature usually are focused on their amalgamation phase, this paper proposes a typology for classifying MCDM methods based on the rationality of their pairwise comparison procedures. Accordingly, four discriminants were used to provide support in choosing MCDM methods based on the typology proposed. The proposed typology allows the analyst to identify the type of rationality from MCDM methods that best fits the multicriteria problem.
DOI: 10.6084/m9.figshare.20337327.v1
title: A TYPOLOGY FOR MCDM METHODS BASED ON THE RATIONALITY OF THEIR PAIRWISE COMPARISON PROCEDURES

description: ABSTRACT MCDM methods have been proposed to select, rank, classify, or describe alternatives based on the process of pairwise comparison. While the typologies of MCDM methods present in the literature usually are focused on their amalgamation phase, this paper proposes a typology for classifying MCDM methods based on the rationality of their pairwise comparison procedures. Accordingly, four discriminants were used to provide support in choosing MCDM methods based on the typology proposed. The proposed typology allows the analyst to identify the type of rationality from MCDM methods that best fits the multicriteria problem.
DOI: 10.6084/m9.figshare.20337329
title: Experience report of the contributions of telehealth in riverside communities of Amazonas in the pandemic

description: ABSTRACT Objective: to report on the creation and implementation of telehealth activities developed by the Forest Health Program in communities in conservation areas, in the state of Amazonas, during the COVID-19 pandemic. Methods: this is an experience report on the creation and implementation of the program. Results: the project began in June 2021 with medical and nursing services and currently has 63 points of connectivity installed. Dermatology was the most requested specialty (30.1%), with dermatitis being the main grievance diagnosed. For nursing, the most requested specialty was obstetrics, followed by pediatrics. Rio Madeira and the Catuá-Ipixema Extractive Reserve requested more than half of all consultations. Conclusion: this project showed a differentiated performance of telehealth in riverside communities in Amazonas, especially in the pandemic context, expanding health care in remote areas, such as these.
DOI: 10.6084/m9.figshare.20337329.v1
title: Experience report of the contributions of telehealth in riverside communities of Amazonas in the pandemic

description: ABSTRACT Objective: to report on the creation and implementation of telehealth activities developed by the Forest Health Program in communities in conservation areas, in the state of Amazonas, during the COVID-19 pandemic. Methods: this is an experience report on the creation and implementation of the program. Results: the project began in June 2021 with medical and nursing services and currently has 63 points of connectivity installed. Dermatology was the most requested specialty (30.1%), with dermatitis being the main grievance diagnosed. For nursing, the most requested specialty was obstetrics, followed by pediatrics. Rio Madeira and the Catuá-Ipixema Extractive Reserve requested more than half of all consultations. Conclusion: this project showed a differentiated performance of telehealth in riverside communities in Amazonas, especially in the pandemic context, expanding health care in remote areas, such as these.
DOI: 10.6084/m9.figshare.20337332
title: EFFECTS OF AEROBIC EXERCISE ON BODY MORPHOLOGY IN OBESE UNIVERSITY STUDENTS

description: ABSTRACT Introduction The problem of obesity is relevant to the current social development model. In addition to the eminent physical health risks, obese university students also experience greater resistance to social development. Obese students participating in the national weight loss fitness program can perceive the benefits of aerobic exercise. Objective Explore the effect of aerobic exercise on body morphology in obese university students. Methods 60 obese university students were selected as study subjects and divided equally into a control and experimental group. The control group received no intervention, while the experimental group performed a battery of aerobic exercises of 60 minutes daily, four times a week for six weeks. Data before and after the experiment were compared. BMI, body fat rate, blood lipid monitoring, and blood glucose were also taken as body component monitoring indexes, and circumference measurements and proportions were taken as external body monitoring indexes. Results Aerobic exercise can effectively reduce the body weight, body mass index (BMI), body fat rate, and body circumference of college students, decrease body weight, make the body shape more symmetrical, and also improve lipid and glycemic components, thus reducing the complications caused by obesity. Conclusion University professors should perform aerobic training for university students to improve their physical fitness, regulate their physical function, and improve their physical appearance. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.