cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15151/esrf-es-2238177433
title: Correlative X-ray holographic nanotomography and spatial transcriptomics in the mouse brain olfactory bulb

description: The detection and discrimination of odours is efficiently performed by the olfactory system of most living species, yet a mechanistic understanding is not clear: the ‘olfactory code’, linking chemical identity to activated neurons - is lacking. Here we aim to reveal this code by studying a ~0.3mm^3 volume of tissue of the mouse olfactory bulb. We will for the first time correlate the spatial transcriptome of a soft tissue with its sub-500nm detailed structure brought by X-ray holographic nanotomography on fixed, frozen, unstained brain tissue. This experiment will reveal the identity of neighbouring glomerular columns, their gain and the molecular diversity of projection neurons that sample the same glomerulus. Altogether, our study will establish the first protocol to reveal subcellular structure and molecular insights on the same neuronal circuit, and pave the way for future research in systems neuroscience as well as in broader soft tissue research.
DOI: 10.15151/esrf-es-2238040591
title: Temperature Effects on the Synthesis of Ethanol over Metal-Oxide Supported Nanoparticles

description: While Higher Alcohol Synthesis (HAS) from syngas (CO/H2) has been extensively studied, the use of CO2 as the carbon feedstock is significantly less explored due to lower performance. Notably, this approach could more directly reduce anthropogenic CO2 emissions (with green/blue H2), making HAS from CO2 highly desirable. However, effective catalysts for this reaction are still rare and poorly understood. Notably, Rh-based catalysts display so far some of the best selectivities for ethanol, when doped with an alkali metal (Li). More recent work from our group has also shown that the reaction temperature and specific thermal retreatment have a substantial impact on the reactivity and ethanol selectivity of M1M2@SiO2 catalysts. We aim to investigate the origin of these temperature dependencies, by studying tailored metal-oxide-supported, transition metal-based catalysts, doped with various promoters thanks to surface organometallic chemistry (SOMC).
DOI: 10.15151/esrf-es-2238044575
title: Towards microsecond XPCS at the ESRF

description: The objective of this proposal is to provide instrumentation which facilitates measuring microsecond dynamics of radiation-sensitive samples such as protein systems via multi-speckle X-ray photon correlation spectroscopy (XPCS) at the ESRF-EBS. We propose to purchase and integrate an XSPA RIGKAU detector for the new coherence flagship beamline ID 18 at ESRF-EBS making ideal use of the increased coherence properties of the EBS. The XSPA detector provides a sustained frame rate of 56 kHz. Running the detector in a special burst mode with lower duty cycle it is possible to trace dynamics as fast a microsecond – a time scale typical for diffusion of proteins on the nanoscale in dense cellular environments. We plan to test the new instrumental XPCS capabilities first at ID10 and ID02 including commissioning and implementation for user experiments. With the completion of ID18 we will transfer it to the new beamline. The detector will be bought from an already secured BMBF grant.
DOI: 10.15151/esrf-es-2238044583
title: AI-driven nano-imaging of bone lacuno-canalicular network: unraveling early osteoporosis signs

description: Osteoporosis alters bone quality at the nanoscale, yet conventional diagnostic methods fail to capture early-stage changes in the lacuna-canalicular network (LCN). To bridge this gap, we propose a multi-scale, AI-enhanced imaging approach at ESRF beamline ID16B, integrating holotomography for large-field-of-view assessments and ptychography for ultra-high-resolution imaging. Healthy and osteoporotic trabecular bone samples from femoral heads will be analyzed, with mechanical testing conducted outside the hutch to track damage evolution in marked regions. AI-driven segmentation and data augmentation will enhance feature detection and enable predictive modeling of LCN deterioration. This study will generate the first large-scale quantitative dataset of osteoporotic LCN degradation, advancing early diagnosis and therapeutic strategies.
DOI: 10.6084/m9.figshare.30551129
title: Datasets for: Structure and Function of Lens Suture Examined by 2-photon Fluorescence Microscopic Imaging

description: Datasets for our manuscript: Structure and Function of Lens Suture Examined by 2-photon Fluorescence Microscopic Imaging
DOI: 10.15151/esrf-es-2238049433
title: Mixed CH4-CO2 hydrates in large icy satellites

description: This proposal is a continuation of the proposal ES-1540, where we investigated mixed gas clathrates of CH4 and CO2 at low-pressure – high-pressure conditions of large icy satellites, in the framework in the ANR project “CAGES”. Mixed gas clathrates are expected to be abundant phases of large ocean worlds, and knowledge of their polymorphism is essential to understand the chemical evolution and astrobiological potential of these unique planetary bodies. However, our knowledge of the stability and structural properties of mixed clathrates at conditions relevant to the interiors of large icy satellites remains essentially unknown. Herein, we propose to finalize our exploration of the most chemically relevant, CH4-CO2, mixed gas hydrates at various P-T-composition conditions, by applying in-situ X-ray diffraction in cryostat-cooled diamond anvil cells.
DOI: 10.6084/m9.figshare.30551129.v1
title: Datasets for: Structure and Function of Lens Suture Examined by 2-photon Fluorescence Microscopic Imaging

description: Datasets for our manuscript: Structure and Function of Lens Suture Examined by 2-photon Fluorescence Microscopic Imaging
DOI: 10.15151/esrf-es-2262569992
title: Imaging the Full strain tensor around through-silicon vias: a pioneer study of the complementarity between µLaue and DFXM

description: Through-Si vias TSVs, an elegant interconnection technique in 3D integrated microelectronics, allow for efficient use of space, providing electrical paths between layers while improving signal propagation and reducing power consumption. These elements introduce mechanical stress in the silicon, which can affect the reliability and performance of the device. Although significant research has been dedicated to understanding and mitigating the deformation fields surrounding the TSVs, here we propose a new approach to characterizing the strain field reach around the TSVs and delimiting the "keep-out-zones" with a strain resolution of 10-5, in a non destructive manner and providing a full strain tensor. Since TSVs are a well known system this will serve a proof of concept for a dual quantitative strain characterization method based on two state of the art synchrotron X ray diffraction techniques: Laue Microdiffraction and Dark field X ray microscopy.
DOI: 10.6084/m9.figshare.30579032
title: Pre-dialysis medical social worker support and survival in patients with kidney failure: impact on unplanned dialysis, hospitalization, and prognosis

description: The role of medical social workers (MSWs) in managing patients with end-stage kidney disease (ESKD) undergoing hemodialysis remains unknown. This study evaluated the prognostic impact of pre-dialysis MSW support in patients undergoing renal replacement therapy. This retrospective analysis included 257 patients who started hemodialysis at the Nagasaki Harbor Medical Center between 2016 and 2023. Patients were divided into MSW (+) and MSW (−) groups based on whether they received pre-dialysis MSW support. Outcomes were assessed, including unplanned dialysis initiation, length of hospital stay, and post-hemodialysis survival. The MSW (+) group showed a lower rate of unplanned dialysis initiation, shorter hospital stays and improved post-hemodialysis prognosis compared with the MSW (−) group. In the multivariable Cox regression analysis, pre-dialysis MSW support (hazard ratio 0.58, 95% confidence interval 0.34–0.98, <i>p</i> = 0.04) was associated with lower patient mortality in addition to age, male sex, serum albumin levels 1 month before hemodialysis initiation, and serum creatinine levels 1 month before hemodialysis initiation. Stratified analyses showed a marked positive impact of MSW support in patients aged ≥70 years, male sex, living with family, and malnutrition. MSW support facilitated smoother transitions to maintenance hemodialysis centers through pre-settlement dialysis centers, alleviated patient anxiety, and ensured transportation arrangements. This study highlights the critical role of MSWs in improving clinical outcomes for patients with ESKD who are at higher social risks. Future multicenter studies are warranted to validate these findings and enhance their generalizability.
DOI: 10.15151/esrf-es-2237623017
title: Biodiversity recovery after Olson's extinction event

description: The existence of Olson's extinction, 270-275 million years ago, and the impact it had on mammalian ancestors are currently among the most hotly debated topics in palaeontology. We here propose to describe, based on synchrotron scanning, the newest, most complete, and best dated fossil fauna documenting the biodiversity recovery after this extinction. This project has the potential to highlight the evolutionary and ecological dynamics of terrestrial ecosystems right after Olson’s extinction and document how it affected mammalian ancestors in an unprecedented way.
DOI: 10.6084/m9.figshare.30579032.v1
title: Pre-dialysis medical social worker support and survival in patients with kidney failure: impact on unplanned dialysis, hospitalization, and prognosis

description: The role of medical social workers (MSWs) in managing patients with end-stage kidney disease (ESKD) undergoing hemodialysis remains unknown. This study evaluated the prognostic impact of pre-dialysis MSW support in patients undergoing renal replacement therapy. This retrospective analysis included 257 patients who started hemodialysis at the Nagasaki Harbor Medical Center between 2016 and 2023. Patients were divided into MSW (+) and MSW (−) groups based on whether they received pre-dialysis MSW support. Outcomes were assessed, including unplanned dialysis initiation, length of hospital stay, and post-hemodialysis survival. The MSW (+) group showed a lower rate of unplanned dialysis initiation, shorter hospital stays and improved post-hemodialysis prognosis compared with the MSW (−) group. In the multivariable Cox regression analysis, pre-dialysis MSW support (hazard ratio 0.58, 95% confidence interval 0.34–0.98, <i>p</i> = 0.04) was associated with lower patient mortality in addition to age, male sex, serum albumin levels 1 month before hemodialysis initiation, and serum creatinine levels 1 month before hemodialysis initiation. Stratified analyses showed a marked positive impact of MSW support in patients aged ≥70 years, male sex, living with family, and malnutrition. MSW support facilitated smoother transitions to maintenance hemodialysis centers through pre-settlement dialysis centers, alleviated patient anxiety, and ensured transportation arrangements. This study highlights the critical role of MSWs in improving clinical outcomes for patients with ESKD who are at higher social risks. Future multicenter studies are warranted to validate these findings and enhance their generalizability.
DOI: 10.15151/esrf-es-2237624458
title: Tracking the cross-linking mechanism of a metal-organic EUV photoresist using GISAXS

description: Extreme ultraviolet (EUV) lithography has entered high-volume manufacturing enabling the production of integrated circuits with few tens of nanometer sized features on wafers. However, the exposure mechanism of EUV photoresists is still not completely understood, which will limit the advancement for future technology nodes. Employing Grazing Incidence Small Angle X-Ray Scattering at the DUBBLE beamline we want to track and quantify the cross-linking of model tin-oxo cage photoresists upon EUV exposure by determining the particle size of resist thin films exposed at different doses and which have undergone different processing conditions. The particle (or unit) size of the cross-linked structure is a fundamental parameter that is linked to the spatial limit at which features can be printed in a photoresist. Resolving the evolution of the unit size during lithographic processing is critical for designing the highest resolution photoresist materials.
DOI: 10.15151/esrf-es-2237628359
title: 4D Vesiculation Dynamics in Basaltic Magma Under High Pressure and High Temperature

description: Transitions between effusive and explosive activity at basaltic volcanoes are strongly influenced by magma permeability, which is controlled by bubble nucleation, growth and coalescence during ascent. Here, we propose the first 4D (3D space+time) vesiculation experiments with an in-situ view to study bubble growth, coalescence, and permeability evolution of basaltic magma under high-pressure and high-temperature conditions. By combining fast X-ray synchrotron microtomography with a novel Internally Heated Pressure Vessel, we will simulate magma ascent within the crust at pressures up to 150 MPa in presence of volatiles. These experiments will provide the first 4D quantitative insights into bubble kinetics in basaltic magma under pre- and syn-eruptive conditions. The results will be integrated into numerical models, representing a critical step to improve our understanding of magma behaviour and enhancing our ability to forecast and mitigate the risks associated with basaltic eruptions.
DOI: 10.15151/esrf-es-2237632318
title: Monitoring the compression of silicate melts by XAFS on minor elements at Earth’s lower mantle pressures

description: In this follow-up proposal, we will focus on the investigation of supercooled melts in-situ at temperatures above the glass transition, using a resistively heated diamond anvil cell. We plan to extend our dataset on the pressure and temperature (P/T) induced structural changes around the cations Strontium and Yttrium (earth alkaline and rare earth elements) contained in the melt and glasses at pressures relevant to the deep Earth’s mantle (up to 130 GPa) at temperatures of the super-cooled melt state, where the melt structure already relaxes to the extreme pressure. Resistive heating and the lower temperature will facilitate more stable conditions then by laser-heating.
DOI: 10.6084/m9.figshare.30578951.v8
title: Pan-Atlantic University, Lagos 2025/26 (Admission Form (1st & 2nd) Batch Admission list is out Call ☎️(07035392356) OR ☎️(+2347035392356) DR RITA on how to apply for Jupeb/Ijmb form, Transfer form, Direct entry form, Masters, PGD and Phd form Call ☎️(07035392356) OR ☎️(+2347035392356)

description: Pan-Atlantic University, Lagos 2025/26 (Admission Form (1st & 2nd) Batch Admission list is out Call ☎️(07035392356) OR ☎️(+2347035392356) DR RITA on how to apply for Jupeb/Ijmb form, Transfer form, Direct entry form, Masters, PGD and Phd form Call ☎️(07035392356) OR ☎️(+2347035392356)
DOI: 10.15151/esrf-es-2237633041
title: Assess the stability of Pt NPs supported on MO2/C (M = Ce, Zr, Sn) electrocatalysts during realistic operando oxygen reduction reactions at

description: A promising class of catalysts for O2 reduction in Proton Exchange Membrane fuel cells is Pt nanoparticles (NPs) loaded on metal oxides (MOx)- carbon(C) supports. This research explores Pt NPs on MOx, such as CeO2, ZrO2, and SnO2, and carbon supports to enhance ORR activity and corrosion resistance. A commercially available electrochemical half-cell will be adopted to perform operando combined small- and wide-angle X-ray scattering measurements (SAXS /WAXTS) during accelerated stress tests. Data analysis through the DSE method will provide a detailed morphological and structural characterization of the catalysts. The results, will allow us to model the Pt and MOx particle evolution, under the effect of the applied potential mode, in terms of particle dimension, shape, strain, crystallinity, oxide stability, alloy formation, and metal leaching, leading to an in-depth comprehension of the mechanisms regulating the activity and durability of this promising class of materials.
DOI: 10.15151/esrf-es-2237119473
title: In situ determination of platinum properties in sulfur-rich carbonate melts

description: Chalcophile metals are bonded to sulfur (S) in magmas, which is the key player in mass transfers of these elements between the Earth’s major silicate reservoirs (mantle and crust). Geochemical studies of mantle-derived magmas suggest S recycling processes from the surface to the mantle and back again. Geophysical methods indicate the widespread occurrence of potentially S-rich, carbonate magmas in the mantle. Yet, a major gap in our knowledge concerns the properties of metals and S in carbonate melts (i.e. speciation and solubility), which control geochemical transport. We propose to shed light on metal and S cycling on Earth, using unprecedented X-ray spectroscopic measurements to determine these properties in situ. The results will provide novel quantitative constraints on the modes and extents of metal and S transfer in the mantle. They will modify our current views of these cycles and the processes forming critical metal deposits in the crust.
DOI: 10.15151/esrf-es-2237119826
title: Impact of fission products on the microstructural and thermophysical properties of (U,Pu)O2-x

description: U1-yPuyO2-x mixed oxide fuels with 20% &lt; y &lt; 35% are currently considered the best candidate for Sodium-cooled Fast neutron Reactors. During irradiation, the chemical composition of MOx fuels changes due to the continuous generation of fission products (FPs), resulting in a heterogeneous materials. A key point of reactor safety is to ensure that no local melting can occur during irradiation. However, experimental data on the melting point of (U,Pu)O2-x fuel remain scarce due to the extreme radiotoxicity of these materials. To overcome this challenge, we have developed a strategy based on (U,Pu)O2-x materials doped with 11 non-radioactive FPs (SIMMOx) to replicate both composition and microstructure of spent fuel. Laser-heating experiments, carried out under different atmospheres on SIMMOx samples, have allowed us to determine their melting points. Nevertheless, these results must be correlated with actinide and FPs oxidation states to better assess their impact on thermal properties.
DOI: 10.15151/esrf-es-2237121622
title: High pressure XLD and scXRD measurements of Zr-based nanolamellar carbide single crystals patterned by Focused Ion Beam

description: Zr-based MAX phase carbides are unique candidates for nuclear fuel cladding applications. Improving the knowledge of their physical properties and their evolution in harsh conditions is key for developing such applications. We are the only group growing single crystals of Zr3SnC2 and Zr2SnC, and we can use Xe-based Focused Ion Beam to tailor crystal dimensions and orientation at will. We will assess the dependence of the electronic and bonding properties of Zr and Sn under pressure up to 30GPa, through the measurement of X-Ray linear dichroism absorption (XLD) and single crystal X-Ray diffraction (scXRD) as a function of p up to 30GPa and temperature up to 800°C.
DOI: 10.15151/esrf-es-2237122686
title: Tracking pore formation during discharge in solid state Sodium batteries

description: Understanding the stripping behavior of sodium (Na) metal anodes in solid-state batteries (SSBs) is crucial for improving their performance and longevity. During stripping, voids form at the Na/solid electrolyte interface, leading to increased resistance, inhomogeneous current distribution, and capacity loss. This study employs operando X-ray nano-diffraction at ID13 to investigate the relationship between stripping conditions and pore formation. Using a novel pressure-controlled setup, NaSICON-based symmetrical Na-metal cells will be analyzed under varying current densities (0.1–1 mA/cm²) and stack pressures (0–10 MPa). A 70 nm X-ray beam in SAXS/WAXS geometry will track the evolution of pores, stress, and phase changes with high spatial resolution. The findings will inform strategies for interfacial engineering, pressure optimization, and cycling protocols, enhancing SSB durability and safety. Additionally, the development of this operando setup will enable future studies on interfac
DOI: 10.15151/esrf-es-2237124755
title: Overcoming sample limitations to enable time-resolved characterisation of a wider range of protein dynamics

description: Here we propose method development at the time-resolved X-ray solution scattering (TR-XSS) beamline ID09 to enable characterization of a wider range of protein targets. Our previous studies have provided critical insights into structural intermediates of eukaryotic calcium transporter SERCA1a, cooperative protein dynamics in adenylate kinase, and the rate-limiting step in bacterial calcium transport. However, the need for large sample volumes in pump-based delivery systems have limited the target proteins and also caged compounds. To overcome these limitations, we propose the use of a fixed-target microchamber chip, which will dramatically reduce demands on both the protein and caged compound. Successful implementation will enable the study of challenging protein targets such as human G-protein coupled receptors (GPCRs) and ligand-gated ion channels (LGICs), which are critical to human physiology and disease intervention.
DOI: 10.15151/esrf-es-2237129307
title: Influence of annealing and high energy ion irradiations on the Xe state in UO2

description: Uranium dioxide is used as standard nuclear fuel in light water reactors. During in-reactor operations, UO2 is subjected to simultaneous irradiations of various energetic particles. Fission fragments, like rare gases (Kr, Xe), transfer their energy to atomic nuclei and/or electrons of the target and induce a significant amount of damages, in particular gaseous bubbles, affecting the fuel in pile performances. To better understand the fuel changes, we are studying the Xe bubble growth and re-solution in UO2. Xe implantations at high-fluence were first carried out, followed by various thermal annealing to obtain different bubble populations, and finally different high-energy ion irradiations to promote re-solution. TEM was used to follow the Xe bubble evolution at nanometric scale. XAS measurements would allow us to obtain more information on the Xe state and environment with a larger representative volume after annealing and re-solution.
DOI: 10.15151/esrf-es-2237132087
title: Investigating strain-induced effects in superconducting infinite-layer nickelate membranes

description: Our initial RIXS investigation of strained NdNiO2 revealed a compelling strain-induced modification of magnetic excitations. However, unexpected, premature membrane cracking hampered a complete investigation. We have since overcome this technical challenge and now propose further RIXS measurements to complete NdNiO2 dataset and to focus on superconducting Nd0.8Sr0.2NiO2 membranes. The comprehensive exploration of strain effects will significantly enhance our understanding of nickelate electronic structure and the ability to manipulate its properties. Furthermore, this work will establish RIXS as a powerful tool for investigating strained quantum material membranes.
DOI: 10.6084/m9.figshare.30578951.v9
title: American University of Nigeria, Yola 2025/26 (Admission Form (1st & 2nd) Batch Admission list is out Call ☎️(07035392356) OR ☎️(+2347035392356) DR RITA on how to apply for Jupeb/Ijmb form, Transfer form, Direct entry form, Masters, PGD and Phd form Call ☎️(07035392356) OR ☎️(+2347035392356)

description: American University of Nigeria, Yola 2025/26 (Admission Form (1st & 2nd) Batch Admission list is out Call ☎️(07035392356) OR ☎️(+2347035392356) DR RITA on how to apply for Jupeb/Ijmb form, Transfer form, Direct entry form, Masters, PGD and Phd form Call ☎️(07035392356) OR ☎️(+2347035392356)