cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24198606.v1
title: Supplementary Material for: Effects of cell-adhesive ligand presentation on pentapeptide supramolecular assembly and gelation: Simulations and Experiments

description: The extracellular matrix (ECM) is a complex, hierarchical material containing structural and bioactive components. This complexity makes decoupling the effects of biomechanical properties and cell-matrix interactions difficult, especially when studying cellular processes in a 3D environment. Matrix mechanics and cell adhesion are both known regulators of specific cellular processes such as stem cell proliferation and differentiation. However, more information is required about how such variables impact various neural lineages that could, upon transplantation, therapeutically improve neural function after central nervous system (CNS) injury or disease. Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) hydrogels are one biomaterial approach to meet these goals, consisting of a family of peptide sequences that assemble into physical hydrogels in physiological media. In this study, we studied our previously reported supramolecularly-assembling RAPID hydrogels functionalized with the ECM-derived cell adhesive peptide ligands RGD, IKVAV, and YIGSR. Using molecular dynamics simulations and experimental rheology we demonstrated that these integrin-binding ligands at physiological concentrations (3-12 mM) did not impact assembly of the KYFIL peptide system. In simulations, molecular measures of assembly such as hydrogen bonding and pi-pi interactions appeared unaffected by cell-adhesion sequence or concentration. Visualizations of clustering and analysis of solvent accessible surface area (SASA) indicated that the integrin-binding domains remained exposed. KYFIL or AYFIL hydrogels containing 3 mM of integrin-binding domains resulted in mechanical properties consistent with their non-functionalized equivalents. This strategy of doping RAPID gels with cell-adhesion sequences allows for the precise tuning of peptide ligand concentration, independent of the rheological properties. The controllability of the RAPID hydrogel system provides an opportunity to investigate the effect of integrin-binding interactions on encapsulated neural cells to discern how hydrogel microenvironment impacts growth, maturation, or differentiation.
DOI: 10.5281/zenodo.8379557
title: Menghubungkan Data Musik dari Spotify dan YouTube dengan Menggunakan Vocabularies Extended dan Linked Data

description: <strong>Menghubungkan Data Musik dari Spotify dan YouTube dengan Menggunakan Vocabularies dan Linked Data. Dataset diambil dari link </strong>Spotify and Youtube (kaggle.com)
DOI: 10.5281/zenodo.8379556
title: Menghubungkan Data Musik dari Spotify dan YouTube dengan Menggunakan Vocabularies Extended dan Linked Data

description: <strong>Menghubungkan Data Musik dari Spotify dan YouTube dengan Menggunakan Vocabularies dan Linked Data. Dataset diambil dari link </strong>Spotify and Youtube (kaggle.com)
DOI: 10.5281/zenodo.8370559
title: CSS-2: Temperature retrieval December 2018

description: Simulated CAIRT retrieval results for temperatures from JAGUAR simulation; 5-day free model run initialized from JAGUAR assimilation; Dec 2018
DOI: 10.5281/zenodo.8370560
title: CSS-2: Temperature retrieval December 2018

description: Simulated CAIRT retrieval results for temperatures from JAGUAR simulation; 5-day free model run initialized from JAGUAR assimilation; Dec 2018
DOI: 10.25345/c5p26qd8m
title: MassIVE MSV000092959 - Single-cell sequencing, quantitative proteomics, and organoids from morphologically normal fallopian tubes of BRCA mutation carrier women show altered epithelial cell differentiation and abnormal response to ovarian hormones.
title: Women with BRCA mutations are predisposed to ovarian cancer and undergo risk-reducing surgeries to remove ovaries and fallopian tubes by the age of 35-40 years. The histopathological assessment of their fallopian tubes revealed the presence of ovarian cancer precursor lesions establishing fallopian tubes as a site of origin of this disease. Here, using scRNA seq, quantitative proteomics, and wholemount imaging, we have described expansions of proliferating secretory cells in morphologically normal BRCA mutant fallopian tubes. We developed the next generation of fallopian tube organoids mimicking the complex architecture of the fallopian tissue mucosa. We established 26 different organoid lines from BRCA1/BRCA2/PALB2/BRIP1 mutation carrier women and showed that these organoids phenocopy many features of ovarian cancer precursor lesions and differentially respond to hormones and PARP inhibition. This work addresses a critical knowledge gap concerning the initial phases of ovarian cancer, laying the foundation for improved screening, early detection strategies, and enhanced patient outcomes.
DOI: 10.6084/m9.figshare.24198663
title: Supplementary Material for: Differing definitions of first-ever stroke influence incidence estimates more than trends: a study using linked administrative data

description: Introduction Researchers apply varying definitions when measuring stroke incidence using administrative data. We aimed to investigate the sensitivity of incidence estimates to varying definitions of stroke and lookback periods, and to provide updated incidence rates and trends for Western Australia (WA). Methods We used linked state-wide hospital and death data from 1985-2017 to identify incident strokes from 2005-2017. A standard definition was applied which included strokes coded as the principal hospital diagnosis or the underlying cause of death, with a 10-year lookback used to clear prevalent cases. Alternative definitions were compared against the standard definition by percentage difference in case numbers. Age-standardised incidence rates were calculated, and age- and sex-adjusted Poisson regression models used to estimate incidence trends. Results The standard definition with a 10-year lookback period captured 31,274 incident strokes. Capture increased by 19.3% when including secondary diagnoses, 4.1% when including nontraumatic subdural and extradural haemorrhage, and 8.1% when including associated causes of death. Excluding death records reduced capture by 11.1%. A 20-year lookback reduced over-ascertainment by 2.0% and a 1-year lookback increased capture by 13.3%. Incidence declined 0.6% annually (95% confidence interval -0.9, -0.3). Annual reductions were similar for most definitions except when death records were excluded (-0.1%, CI -0.4, 0.2) and with the shortest lookback periods (greatest annual reduction). Conclusion Stroke incidence has declined in WA. Differing methods of identifying stroke influence estimates of incidence to a greater extent than estimates of trends. Reductions in stroke incidence over time are primarily driven by declines in hospitalised stroke.
DOI: 10.6084/m9.figshare.24198672
title: Shotgun metagenomics demo report (zip compressed). Can use 7zip freeware to extract (https://7-zip.org/).

description: HTML version of Novogene's shotgun metagenomic services.
DOI: 10.6084/m9.figshare.24198672.v1
title: Shotgun metagenomics demo report (zip compressed). Can use 7zip freeware to extract (https://7-zip.org/).

description: HTML version of Novogene's shotgun metagenomic services.
DOI: 10.5281/zenodo.8233370
title: HeatResilientCity II - Arbeitspaket 2.2: Einfluss von Regional- und Stadtklima auf die Hitzebelastung in Gebäuden - Aufbereitete Wetterdaten

description: Dieses Repository enthält aufbereitete <strong>Wetterdaten meteorologischer Messstationen</strong>, welche für das Projekt HeatResilientCity II herangezogen wurden, um den Einfluss des Regional- und Stadtklimas auf die Hitzebelastung im Gebäude mittels thermischer Gebäudesimulationen zu untersuchen. Dabei wurden die <strong>Regionen Dresden, Hamburg, Köln, Stuttgart und Potsdam</strong> betrachtet. Als meteorologischen Messdaten für diese Regionen wurden Messdaten der <strong>Normalperiode 1991-2020</strong> der DWD-Wetterstationen Dresden-Klotzsche, Hamburg-Fuhlsbüttel, Köln-Bonn, Stuttgart-Schnarrenberg und Potsdam verwendet. Messdaten von DWD-Messstationen sind öffentlich zugänglich und können über das DWD-Climate-Data-Center bezogen werden. Datenlücken in den Messdaten, die einen Zeitraum von 6 Stunden nicht überschreiten (<strong>Fehlstunden</strong>), wurden linear interpoliert. Um größere Datenlücken (&gt; 6 h, <strong>Fehltage</strong>) zu füllen, wurden nächstgelegene Ersatzstationen, an denen die benötigten Messdaten (Temperatur, relative Feuchte, diffuse Solarstrahlung, direkte Solarstrahlung, Windgeschwindigkeit, Windrichtung, Bewölkung) vorliegen, herangezogen. Eine Übersicht über die betrachteten Wetterstationen, die Fehlstunden, Fehltage und die genutzten Ersatzstationen ist im Dokument <em>HRC II_Einfluss von Regional- und Stadtklima auf die Hitzebelastung in Gebäuden - Steckbriefe der Messstationen.pdf</em> dargestellt. Da die Messdaten zum Teil in unterschiedlichen Zeitformaten vorliegen (UTC und MEZ), wurden alle Daten auf das einheitliche <strong>Format UTC</strong> gebracht. Die aufbereiteten Messdatensätze für den Zeitraum 1991-2020 liegen je Region als Textdateien vor. Die stündlich aufgelösten Daten sind Tabstopp-getrennt. Jede Datei enthält zudem in den ersten vier Zeilen Informationen zur Messstation und Messgrößen und ist wie folgt zu lesen: Zeile 1: Informationen zu Messdaten basierend auf Messstationen: Breitengrad in Dezimalgrad Längengrad in Dezimalgrad Stationshöhe in m über NN Zeitbezug (0 für UTC+0) Zeile 2: Name der DWD-Station: z. B.Dresden-Klotzsche Zeile 3: Messgrößen: Datum mit Uhrzeit (UTC) Temperatur Relative Feuchte Diffuse Solarstrahlung Direkte Solarstrahlung, Windgeschwindigkeit Windrichtung Bewölkung Zeile 4: Einheiten der Messgrößen: [-] [°C] [%] [W/m²] [W/m²] [m/s] [°] [Oktas] Ab Zeile 5: Stündlich aufgelöste Messdaten Tabstopp-getrennt <strong>Dateien:</strong> <em>HRC II_Einfluss von Regional- und Stadtklima auf die Hitzebelastung in Gebäuden - Steckbriefe der Messstationen.pdf</em> Aufbereitete Wetterdaten (Interpoliert und mit Ersatzdatensätzen) als Text-files im Ordner <em>Stationsdaten_aufbereitet</em>
description: This research was mainly funded by the Federal Ministry of Education and Research (BMBF) in the joint project "HeatResilientCity" (subproject grant number: 01LR2011A und 01LR2011F) and the European Union's Reconstruction and Resilience Facility (ARF) – NextGenerationEU.
DOI: 10.5517/ccdc.csd.cc2b0fb4
title: CCDC 2145365: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|10190|doi:10.1039/D3DT01364B
description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b0fc5
title: CCDC 2145366: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|10190|doi:10.1039/D3DT01364B
description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b0ff7
title: CCDC 2145368: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|10190|doi:10.1039/D3DT01364B
description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2b0ftm
title: CCDC 2145380: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|10190|doi:10.1039/D3DT01364B
description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f0plr
title: CCDC 2234994: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|10190|doi:10.1039/D3DT01364B
description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f2ljn
title: CCDC 2236821: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f3c0y
title: CCDC 2237549: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f51d2
title: CCDC 2239173: Experimental Crystal Structure Determination

description: Related Article: Ryan M. Kirk, Anthony F. Hill|2023|Dalton Trans.|52|13235|doi:10.1039/D3DT02070C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.24198696
title: Supplementary Material for: Limited efficacy of Venetoclax Combination Regimens in Acute Myeloid Leukemia with Extramedullary Relapse

description: The recently approved Bcl-2 inhibitor venetoclax (VEN) has achieved promising outcomes in new and relapsed/refractory (R/R) acute myeloid leukemia (AML). Although its use is not well-established in R/R AML with extramedullary disease (EMD), some reports have shown promising outcomes. We retrospectively analyzed 11 patients of R/R AML with EMD [with (n=4) or without (n=7) concurrent marrow involvement], who were treated with VEN plus decitabine (n=9) or low-dose cytarabine (n=2) between May 2020 and October 2020 in Seoul St. Mary’s Hospital. The median number of prior treatment lines was 3 (1-6) and most (n=9, 81.8%) had multiple sites of EMD. Nine patients (81.8%) received concurrent therapy for EM involvement sites with radiotherapy (RT) (n=4), surgery (n=1) and both of them (n=4). Among 11 patients, four patients (36.4%) had either marrow or EM responses to VEN-combination; EM response was seen in one patient (9.1%, partial response) who had received concurrent radiotherapy (25Gy, 10fx) during 1st cycle of VEN-combination, and other three patients showed marrow response without EM response. After median follow-up of 27.0 months, the median overall survival was estimated to be 5.4 months. To conclude, VEN-combination regimens have shown only modest efficacy in EM recurrence of AML with little impact on eliciting EM response.
DOI: 10.6084/m9.figshare.24198696.v1
title: Supplementary Material for: Limited efficacy of Venetoclax Combination Regimens in Acute Myeloid Leukemia with Extramedullary Relapse

description: The recently approved Bcl-2 inhibitor venetoclax (VEN) has achieved promising outcomes in new and relapsed/refractory (R/R) acute myeloid leukemia (AML). Although its use is not well-established in R/R AML with extramedullary disease (EMD), some reports have shown promising outcomes. We retrospectively analyzed 11 patients of R/R AML with EMD [with (n=4) or without (n=7) concurrent marrow involvement], who were treated with VEN plus decitabine (n=9) or low-dose cytarabine (n=2) between May 2020 and October 2020 in Seoul St. Mary’s Hospital. The median number of prior treatment lines was 3 (1-6) and most (n=9, 81.8%) had multiple sites of EMD. Nine patients (81.8%) received concurrent therapy for EM involvement sites with radiotherapy (RT) (n=4), surgery (n=1) and both of them (n=4). Among 11 patients, four patients (36.4%) had either marrow or EM responses to VEN-combination; EM response was seen in one patient (9.1%, partial response) who had received concurrent radiotherapy (25Gy, 10fx) during 1st cycle of VEN-combination, and other three patients showed marrow response without EM response. After median follow-up of 27.0 months, the median overall survival was estimated to be 5.4 months. To conclude, VEN-combination regimens have shown only modest efficacy in EM recurrence of AML with little impact on eliciting EM response.
DOI: 10.6084/m9.figshare.24198699
title: Supplementary Material for: Limited efficacy of Venetoclax Combination Regimens in Acute Myeloid Leukemia with Extramedullary Relapse

description: The recently approved Bcl-2 inhibitor venetoclax (VEN) has achieved promising outcomes in new and relapsed/refractory (R/R) acute myeloid leukemia (AML). Although its use is not well-established in R/R AML with extramedullary disease (EMD), some reports have shown promising outcomes. We retrospectively analyzed 11 patients of R/R AML with EMD [with (n=4) or without (n=7) concurrent marrow involvement], who were treated with VEN plus decitabine (n=9) or low-dose cytarabine (n=2) between May 2020 and October 2020 in Seoul St. Mary’s Hospital. The median number of prior treatment lines was 3 (1-6) and most (n=9, 81.8%) had multiple sites of EMD. Nine patients (81.8%) received concurrent therapy for EM involvement sites with radiotherapy (RT) (n=4), surgery (n=1) and both of them (n=4). Among 11 patients, four patients (36.4%) had either marrow or EM responses to VEN-combination; EM response was seen in one patient (9.1%, partial response) who had received concurrent radiotherapy (25Gy, 10fx) during 1st cycle of VEN-combination, and other three patients showed marrow response without EM response. After median follow-up of 27.0 months, the median overall survival was estimated to be 5.4 months. To conclude, VEN-combination regimens have shown only modest efficacy in EM recurrence of AML with little impact on eliciting EM response.
DOI: 10.6084/m9.figshare.24198699.v1
title: Supplementary Material for: Limited efficacy of Venetoclax Combination Regimens in Acute Myeloid Leukemia with Extramedullary Relapse

description: The recently approved Bcl-2 inhibitor venetoclax (VEN) has achieved promising outcomes in new and relapsed/refractory (R/R) acute myeloid leukemia (AML). Although its use is not well-established in R/R AML with extramedullary disease (EMD), some reports have shown promising outcomes. We retrospectively analyzed 11 patients of R/R AML with EMD [with (n=4) or without (n=7) concurrent marrow involvement], who were treated with VEN plus decitabine (n=9) or low-dose cytarabine (n=2) between May 2020 and October 2020 in Seoul St. Mary’s Hospital. The median number of prior treatment lines was 3 (1-6) and most (n=9, 81.8%) had multiple sites of EMD. Nine patients (81.8%) received concurrent therapy for EM involvement sites with radiotherapy (RT) (n=4), surgery (n=1) and both of them (n=4). Among 11 patients, four patients (36.4%) had either marrow or EM responses to VEN-combination; EM response was seen in one patient (9.1%, partial response) who had received concurrent radiotherapy (25Gy, 10fx) during 1st cycle of VEN-combination, and other three patients showed marrow response without EM response. After median follow-up of 27.0 months, the median overall survival was estimated to be 5.4 months. To conclude, VEN-combination regimens have shown only modest efficacy in EM recurrence of AML with little impact on eliciting EM response.
DOI: 10.5519/qd.z72819fk
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.6084/m9.figshare.23804016.v1
title: Supplementary Material for: Long-term trajectories of biomarkers, functional, and echocardiographic parameters in patients with chronic heart failure from dilated or ischaemic cardiomyopathy

description: Introduction: The long-term evolution of clinical, echocardiographic and laboratory parameters of cardiac function in patients with chronic heart failure (HF) with either reduced (HFrEF) or mildly reduced (HFmrEF) left ventricular ejection fraction (LVEF) is incompletely characterized. Methods: We identified patients with chronic stable HF who presented at least twice to a university HF outpatient clinic between 1995 and 2021. Trajectories of NYHA functional class, LVEF, left ventricular internal enddiastolic diameter (LVIDD), NT-proBNP concentrations and HF treatment over ten years follow-up were analysed using fractional polynomials. Analyses were repeated after stratifying patients according to aetiology (ischemic vs. dilated) or HF category (HFrEF vs. HFmrEF). Results: A total of 2,132 patients were included, of whom 51% had ischemic and 49% had dilated HF. 86% and 14% were classified as HFrEF and HFmrEF, respectively. Mean LVEF was 28±10%, and median NT-proBNP and eGFR values were 1,170 (385-3,176) pmol/L and 81 (62-100) ml/min/1.73m², respectively. Median follow-up was 5.2 (2.6-9.2) years. Overall, NYHA functional class and LVIDD trajectories were U-shaped, whereas LVEF and NT-proBNP concentrations markedly improved during the first year and remained stable thereafter. However, the evolution of HF parameters significantly differed with respect to HF category and aetiology, with greater improvements seen in patients with HFrEF of non-ischemic origin. Improvements in HF variables were associated with optimization of HF therapy, notably with initiation and up-titration of renin-angiotensin-system blockers. Discussion/Conclusion: This study provides insights into the natural history of HF in a large cohort of well-treated chronic HF outpatients with respect to subgroups of HF and different etiologist.