cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21430/m3fdqr1mgl
title: Safety and immunogenicity of PfSPZ Vaccine in Equatorial Guinea (EGSPZV1)

description: This is a single center, randomized, placebo-controlled, double-blind trial to assess the safety and immunogenicity of PfSPZ Vaccine administered by direct venous inoculation (DVI).The study to be conducted in Baney District, Bioko Island, Equatorial Guinea (EG), will be to establish whether three doses of the higher regimen - three doses of 2.7x10^5 PfSPZ of the PfSPZ Vaccine administered at 8 week intervals - is as well-tolerated and efficacious in malaria exposed African adults as the five dose regimens. Specifically, the trial will address the following objectives: is the three dose regimen: 1. Safe and well tolerated in Equatoguinean (EG) adults. 2. As immunogenic in EG adults as is the five-dose regimen of 1.35x10^5 PfSPZ in Tanzanian and U.S. adults or as three-, four- and five-dose regimens of 2.7x10^5 PfSPZ being tested in Tanzanian, Malian and U.S. adults. In addition, as an exploratory objective, the volunteers in the EG trial will be followed longitudinally to measure the incidence of malaria during the initial six months following immunization, providing a preliminary assessment of efficacy.
DOI: 10.21430/m3frd03j1f
title: One-Stop Serum Assay Identifies COVID-19 Disease Severity and Vaccination Responses

description: In this study, we develop a sensitive anti–SARS-CoV-2 immunoassay, using prepandemic controls and RT-PCR–confirmed, SARS-CoV-2–infected patients
DOI: 10.21430/m3fs3q3tg6
title: Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variants

description: To assess the protective efficacy of natural immunity after WA1/2020 infection on rechallenge with WA1/2020, B.1.1.7, or B.1.351 variants in rhesus macaques.
DOI: 10.21430/m3g3gc8iiz
title: A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques

description: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs. These results support clinical development of ADM03820 for COVID-19 prevention
DOI: 10.21430/m3g3qhv9ug
title: A Retrospective Multicenter Study to Determine Clinical Outcomes in Subjects Previously Enrolled in the CTOTC-03 Study (CTOTC-14)

description: This study is a multicenter, non-randomized, retrospective study to collect long term (5 years post-transplant +/- 6 months) clinical outcome data on subjects previously enrolled in the CTOTC-03 study.
DOI: 10.21430/m3gbs3iqlc
title: The effect of secretor status and the vaginal microbiome on birth outcome

description: To test the hypothesis of that maternal secretor status (by mutated FUT2 gene) might influence the composition of the vaginal microbiota in pregnancy, the study analysed the relationship between secretor status, vaginal microbiota and gestational length in an ethnically diverse cohort of 313 pregnant women, including 91 who delivered prematurely. The results point towards stratification by secretor status as an important factor for considering preterm birth risk and prevention.
DOI: 10.21430/m3gskyh5jh
title: SARS-CoV-2 Spreads through Cell-to-Cell Transmission

description: Herein we provide evidence that SARS-CoV-2 spreads through cell-cell contact in cultures, mediated by the spike glycoprotein. SARS-CoV-2 spike is more efficient in facilitating cell-to-cell transmission than SARS-CoV spike, which reflects, in part, their differential cell-cell fusion activity. Interestingly, treatment of cocultured cells with endosomal entry inhibitors impairs cell-to-cell transmission, implicating endosomal membrane fusion as an underlying mechanism. Compared with cell-free infection, cell-to-cell transmission of SARS-CoV-2 is refractory to inhibition by neutralizing antibody or convalescent sera of COVID-19 patients. While ACE2 enhances cell-to-cell transmission, we find that it is not absolutely required. Notably, despite differences in cell-free infectivity, the variants of concern (VOC) B.1.1.7 and B.1.351 have similar cell-to-cell transmission capability. Moreover, B.1.351 is more resistant to neutralization by vaccinee sera in cell-free infection, whereas B.1.1.7 is more resistant to inhibition by vaccine sera in cell-to-cell transmission. Overall, our study reveals critical features of SARS-CoV-2 spike-mediated cell-to-cell transmission, with important implications for a better understanding of SARS-CoV-2 spread and pathogenesis.
DOI: 10.21430/m3gylhg31l
title: Gestational Dating by Urine Metabolic Profile at High Resolution Weekly Sampling Timepoints

description: The study characterizes the weekly baseline profile of the human pregnancy metabolome of urine samples from two normal pregnancy cohorts (discovery: 478 samples from 19 subjects at California; validation: 171 samples from 10 subjects at Alabama). Results: 5,473 urinary metabolic features were identified by LC-MS untargeted metabolomics. Prediction models (on six urine metabolites) were constructed based on gradient-boosting decision trees to date gestational age in high accordance with ultrasound results, and to accurately predict time to delivery.
DOI: 10.21430/m3h1yhlr5z
title: Urban Environmental Factors and Childhood Asthma (URECA) (ICAC-07)

description: Minority children who grow up in poor urban neighborhoods have the highest rates of asthma, and also experience greater morbidity from acute exacerbations of this disease. The aim of this study is to further identify environmental factors unique to the inner city that affect immune development and the expression of wheezing, atopy and asthma for purposes of identifying new strategies for asthma prevention.
DOI: 10.21430/m3hd6fg5e9
title: Large-scale placenta DNA methylation mega-analysis on fetal sex

description: To identify DNA methylation features (CpGs and regions) associated with fetal sex, a mega-analysis of 532 full term pregnant samples selected from 14 publicly available placenta DNA methylation (DNAm) microarray datasets was conducted. Datasets synthesised from trimesters samples were further examined for features persistance throughout the gestational period. Enriched pathways of keratinization, chemokine activity, and eosinophil and 9 DMRs were identified from differential DNA methylation profiles associated with fetal sex-specific placenta.
DOI: 10.21430/m3hs37cjnw
title: The Metabolic Signature of the Placenta in SPTB

description: To test the hypothesis of the association of SPTB with deficits in the capacity of the placenta to maintain bioenergetic and metabolic stability during pregnancy, a comparative metabolomic analysis of placenta samples from women with SPTB (n=12) and normal pregnancies (n=12) was conducted. A subset of metabolites in non-laboring preterm and term Rhesus monkeys (n=6) was examined for the effects of gestational age on placenta metabolism. The study identified a significant elevation of amino acids, prostaglandins, sphingolipids, lysolipids, and acylcarnitines and lower level of fatty acid oxidation in SPTB placenta. The elevation of acylcarnitines was also confirmed by tandem mass spectrometry in SPTB human, with no significant differences between midgestation and term placenta in Rhesus macaque.
DOI: 10.21430/m3i9mmzogz
title: Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques

description: Here we show that Ad26.COV2.S elicits humoral and cellular immune responses that cross-react with the B.1.351 variant and protects against B.1.351 challenge in rhesus macaques. Ad26.COV2.S induced lower binding and neutralizing antibodies against B.1.351 as compared to WA1/2020, but elicited comparable CD8 and CD4 T cell responses against the WA1/2020, B.1.351, B.1.1.7, P.1 and CAL.20C variants. B.1.351 infection of control rhesus macaques resulted in higher levels of virus replication in bronchoalveolar lavage and nasal swabs than did WA1/2020 infection. Ad26.COV2.S provided robust protection against both WA1/2020 and B.1.351, although we observed higher levels of virus in vaccinated macaques after B.1.351 challenge. These data demonstrate that Ad26.COV2.S provided robust protection against B.1.351 challenge in rhesus macaques. Our findings have important implications for vaccine control of SARS-CoV-2 variants of concern.
DOI: 10.21430/m3idui9tuu
title: Tissue-based SARS-CoV-2 detection in fatal COVID-19 infections: Sustained direct viral-induced damage is not necessary to drive disease progression

description: We first developed a positive control cell line (Vero E6) to validate SARS-CoV-2 detection assays. We then evaluated multiple organs (lungs, kidneys, heart, liver, brain, intestines, lymph nodes, and spleen) from fourteen COVID-19 autopsy cases using immunohistochemistry (IHC) for the spike and the nucleoprotein proteins, and RNA in situ hybridization (RNA ISH) for the spike protein mRNA. qPCR confirmed high viral load in the SARS-CoV-2 ISH-positive lung tissue, and absent or low viral load in all ISH-negative tissues. In patients who die of COVID-19-related organ failure, SARS-CoV-2 is largely not detectable using tissue-based assays. Even in lungs showing widespread injury, SARS-CoV-2 viral RNA or proteins were detected in only a small minority of cases.
DOI: 10.21430/m3ix4ma9l9
title: Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera

description: To investigate cross-neutralization of the B.1.1.7 and B.1.351 SARS-CoV-2 variants in a well-characterized cohort of early pandemic convalescent subjects
DOI: 10.21430/m3ix6db4q8
title: Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

description: To evaluate protective efficacy of human antibodies elicited by Ad26.COV2.S vaccination by adoptive transfer studies
DOI: 10.21430/m3jp0uevb0
title: Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms

description: To examine how vaccine platforms and timing of vaccination in pregnancy impact maternal and neonatal immunity.
DOI: 10.21430/m3k94pivey
title: Flow cytometer data for investigation into an integrated microfluidic system for basophil isolation from whole blood

description: Purity, recovery, and artificial activation from various system modalities and parameters
DOI: 10.21430/m3krz9glcr
title: Does a lack of vaccine side effects correlate with reduced BNT162b2 mRNA vaccine response among healthcare workers and nursing home residents?

description: With a significantly lower incidence of post-vaccination reactions among NH residents as reported in this study, the BNT162b2 mRNA vaccine appears to be well-tolerated among this vulnerable population. If validated in larger populations, absence of reactogenicity could help guide clinicians in prioritizing vaccine boosters. Reactogenicity is significantly mild among nursing home residents and overall, subjects who reported post-vaccination reactions developed higher antibody titers.
DOI: 10.21430/m3kwasu913
title: mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions

description: To provide insights into potential differences in protective immunity conferred by the BNT162b2 and mRNA-1273 vaccines.
DOI: 10.21430/m3lue504p0
title: Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

description: Probed the ability of vaccine-induced antibodies to drive Fc effector activity against the Omicron variant using samples from individuals receiving one of three SARS-CoV-2 vaccines
DOI: 10.21430/m3m5kq9tv3
title: Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

description: To compare SARS-CoV-2-specific CD4+ and CD8+ T cells against the B.1.1.7, B.1.351, P.1, and CAL.20C lineages in COVID-19 convalescents and in recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines.
DOI: 10.21430/m3m73pfn8o
title: Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

description: The flexible framework can be adapted to optimize serosurvey design given test characteristics and capacity, population demography, sampling strategy, and modeling approach, and can be tailored to support decision-making around introducing or removing interventions.
DOI: 10.21430/m3mk2k78l8
title: Association of CD4+ CD8+ T cells with risk of plasma leakage in Dengue disease

description: This study provides new insight into the host immune response in DENV infection and the role of CD4+CD8+ DP T cells in the pathogenesis of plasma leakage.
DOI: 10.21430/m3mw65jzhd
title: Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques

description: Here we show that adoptive transfer of purified IgG from convalescent macaques protects naive recipient rhesus macaques against SARS-CoV-2 challenge in a dose dependent fashion. Depletion of CD8+ T cells in convalescent animals partially abrogated the protective efficacy of natural immunity against SARS-CoV-2 re-challenge, suggesting the importance of cellular immunity in the context of waning or subprotective antibody titers. These data demonstrate that relatively low antibody titers are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may also contribute to protection if antibody responses are suboptimal. We also show that higher antibody titers are required for therapy of SARS-CoV-2 infection in macaques.
DOI: 10.21430/m3nexziac5
title: Model-informed COVID-19 vaccine prioritization strategies by age and serostatus

description: Use of individual-level serological tests to redirect doses to seronegative individuals improved the marginal impact of each dose while potentially reducing existing inequities in COVID-19 impact.
DOI: 10.21430/m3ng59ffq5
title: Delayed Rise of Oral Fluid Antibodies, Elevated BMI, and Absence of Early Fever Correlate With Longer Time to SARS-CoV-2 RNA Clearance in a Longitudinally Sampled Cohort of COVID-19 Outpatients

description: Ninety-five symptomatic outpatients self-collected midturbinate nasal, oropharyngeal (OP), and gingival crevicular fluid (oral fluid) samples at home and in a research clinic a median of 6 times over 1-3 months. Samples were tested for viral RNA, virus culture, and SARS-CoV-2 and other human coronavirus antibodies, and associations were estimated using Cox proportional hazards models. Sixteen nasal-OP samples collected 2-11 days post-symptom onset were virus culture positive out of 183 RT-PCR-positive samples tested. All participants but 1 with positive virus culture were negative for concomitant oral fluid anti-SARS-CoV-2 antibodies. The mean time to first antibody detection in oral fluid was 8-13 days post-symptom onset. We demonstrate that delayed rise of oral fluid SARS-CoV-2-specific antibodies, elevated BMI, and absence of early fever are independently associated with delayed URT viral RNA clearance.
DOI: 10.21430/m3npevxjwp
title: Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

description: By combining the RNA-centric approach and functional CRISPR screens, the study demonstrated a physical and functional connection between SARS-CoV-2 and mitochondria, highlighting this organelle as a general platform for antiviral activity.
DOI: 10.21430/m3o55demo6
title: Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

description: AdCOVID promotes concomitant systemic and mucosal immunity and represents a promising vaccine candidate
DOI: 10.21430/m3obtzvhiq
title: Virological Characteristics ofHospitalized Children WithSARS-CoV-2 Infection

description: In hospitalized children with SARS-CoV-2, those with .1 comorbid condition experienced severe disease. SARS-CoV-2 VL in the respiratory tract is significantly higher in children with symptomatic disease and children ,1 year of age.
DOI: 10.21430/m3okzi2zxd
title: Systems Immune Profiling of Divergent Responses to Infection - Year2

description: Our ongoing studies investigate mechanisms of individual susceptibility and resistance to infection in order to identify biomarkers of severe disease or potential therapeutic approaches.
DOI: 10.21430/m3onst24p3
title: Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells

description: To evaluate COVID-19 patients longitudinally up to 8 months and find durable broad-based immune responses.
DOI: 10.21430/m3oouuiko5
title: Pseudo-safety in a cohort of patients with COVID-19 discharged home from the emergency department

description: In this retrospective study, we characterised all patients with COVID-19 discharged home from Emergency Department in our US multisite healthcare system from March 2020 to August 2020, focusing on individuals who returned within 2 weeks and required hospital admission. Patients infected with COVID-19 may appear clinically safe for home convalescence. However, those with hypertension, diabetes, chronic lung disease and fever may in fact be only 'pseudo-safe' and are most at risk for subsequent hospitalisation with more severe illness and longer hospital stays.
DOI: 10.21430/m3opv1dvtb
title: Systems Immune Profiling of Divergent Responses to Infection

description: Our ongoing studies investigate mechanisms of individual susceptibility and resistance to infection in order to identify biomarkers of severe disease or potential therapeutic approaches.
DOI: 10.21430/m3ox86b062
title: A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children (ICAC-30)

description: The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.
DOI: 10.21430/m3oy06ealq
title: Age-related signs of immunosenescence correlate with 3 poor outcome of mRNA COVID-19 vaccination in older 4 adults

description: Analysis of the SARS-CoV-2 Spike-specific B and T cell responses in unexposed subjects of various ages, receiving two doses of the BNT162b2 mRNA vaccine and compared with those of age-matched subjects who experienced a mild or asymptomatic 53 SARS-CoV-2 infection.
DOI: 10.21430/m3pvmo2isj
title: Blood and tissue studies of Tick-borne diseases in adults. Blood and tissue studies of Tick-borne diseases in children. Year2

description: The study is designed to look at how the body responds to infection with Lyme disease spirochete and how this response relates to clinical symptoms and infection outcomes.
DOI: 10.21430/m3qnzxmtsj
title: Lactobacillus-depleted vaginal microbiota in HIV-1 pregnant women are associated with increased local inflammation and PTM

description: To characterise the vaginal microbiota of a UK cohort of pregnant women living with HIV-1 infection (PWLWH, n=53) sampled longitudinally throughout gestation compared to HIV uninfected pregnant women (HUPW, n-22) using metataxonomic profiling and to determine if differences in vaginal microbiota composition of PWLWH influence local inflammation and subsequent risk of PTB. The prospective study revealed an association between local inflammation, vaginal dysbiosis and PTB in PWLWH.
DOI: 10.21430/m3qpejcgy4
title: Human Placental Transcriptome and fetal sex differences in SPTB

description: The study performed a RNA-seq analysis in male and female placentas from 16 women with SPTB (<36 weeks gestation) compared to 16 normal pregnancies (≥38 weeks gestation) to assess the alterations in the gene expression profiles. The transcriptome was integrated with published human placental metabolome to assess the interactions of altered genes and metabolites. Collectively, significant and biologically relevant alterations in the transcriptome were identified in SPTB placentas with fetal sex disparities. Altered energy metabolism, mitochondrial function, inflammation, and detoxification may underly the mechanisms of placental dysfunction in SPTB
DOI: 10.21430/m3rlfpeuym
title: Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

description: To evaluate the immunogenicity of Ad26.COV2.S vaccine in humans against SARS-CoV-2 variants .
DOI: 10.21430/m3s0t656kv
title: Longitudinal analysis of severe acute respiratory syndrome coronavirus 2 seroprevalence using multiple serology platforms

description: To compare seroprevalence using research-grade RBD and spike based ELISA, a commercial RBD and spike-based ELISA, and a commercial NP-based immunoassay in health care workers
DOI: 10.21430/m3s4gr1bio
title: Interpreting vaccine efficacy trial results for infection and transmission

description: Applying simulation approach to published data from the RCT of the Moderna vaccine, we estimate that one dose of vaccine reduces the potential for transmission by at least 61%, possibly considerably more.
DOI: 10.21430/m3s4ozjrcn
title: Kinetics of immunological memory to SARS-CoV-2

description: We assessed the kinetics and durability of SARS-CoV-2-specific antibodies, CD4+ T cells, and CD8+ T cells made in response to SARS-CoV-2 infection in a predominantly cross-sectional study extending up to eight months post-infection.
DOI: 10.21430/m3s6ccm01k
title: A humanized mouse model of chronic COVID-19

description: Here we describe a humanized mouse model of COVID-19 that uses adeno-associated virus to deliver human ACE2 to the lungs of humanized MISTRG6 mice. This model recapitulates innate and adaptive human immune responses to severe acute respiratory syndrome coronavirus 2 infection up to 28 days after infection, with key features of chronic COVID-19, including weight loss, persistent viral RNA, lung pathology with fibrosis, a human inflammatory macrophage response, a persistent interferon-stimulated gene signature and T cell lymphopenia. We used this model to study two therapeutics on immunopathology, patient-derived antibodies and steroids and found that the same inflammatory macrophages crucial to containing early infection later drove immunopathology. This model will enable evaluation of COVID-19 disease mechanisms and treatments.
DOI: 10.15468/dl.vjea6x
title: Occurrence Download

description: A dataset containing 2170 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Heliotropium ellipticum Ledeb."
 ]
}

 The dataset includes 2170 records from 58 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0105995-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.78srcj
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Xylella fastidiosa Wells et al., 1987)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1900",
 "BasisOfRecord is one of (Human Observation)",
 "Country is one of (Australia)",
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than or equal to 20000",
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 ]
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0105998-240626123714530/datasets/export for details.