cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34810/data2656
title: Replication data for "Subcutaneous administration of an endocrine-mimetic platform allows for prolonged tumor-uptake of a tumor-targeted protein"

description: The dataset includes the physicochemical and in vivo characterization data supporting the article “Subcutaneous administration of an endocrine-mimetic platform allows for prolonged tumor-uptake of a tumor-targeted protein.” It contains measurements of protein size, polydispersity, zeta potential, morphology, and release kinetics of zinc-induced secretory granules (SGs) obtained by DLS, FESEM, and TEM, as well as fluorescence-based biodistribution data in mice after subcutaneous, intramuscular, and intraperitoneal administration. The results demonstrate that subcutaneous administration ensures the most sustained protein release and highest tumor accumulation of the CXCR4-targeted T22-GFP-H6 protein.
description: METHODOLOGICAL INFORMATION

1. Description of methods used for collection-generation of data: 
Data were obtained through the design, production, and characterization of the recombinant protein T22?GFP?H6. The protein was expressed in E. coli after IPTG induction and purified by affinity chromatography. Its purity, integrity, and concentration were analyzed by SDS?PAGE, western blot, MALDI?TOF mass spectrometry, and Bradford assay. Secretory granules were formed by zinc?induced precipitation and characterized by dynamic light scattering (DLS), electrophoretic light scattering (ELS), and electron microscopy (FESEM and TEM). Protein release was measured by UV spectrophotometry. In vivo biodistribution was assessed in a CXCR4? colorectal cancer mouse model using IVIS fluorescence imaging, while tissue analysis was performed by hematoxylin?eosin and immunohistochemistry.


2. Methods for processing the data: 
GraphPad Prism 8.0.2 software was used to establish statistical significance. An initial assessment of normality and log-normality using the Shapiro-Wilk test was performed to verify the data’s normal distribution. For parametric data, a one-way ANOVA test was applied; for nonparametric  data, the Kruskal-Wallis test was used. All measurements were performed at least in triplicate, and data were expressed as mean ± standard  error of the mean (SEM). Statistical significance (*) was considered to be achieved when p &lt; 0.05. The 3D protein structure.


3. Instrument- or software- specific information needed to interpret the data:
GraphPad Prism 8.0.2 software was used to establish statistical significance. An initial assessment of normality and log-normality using the Shapiro-Wilk test was performed to verify the data’s normal distribution. For parametric data, a one-way ANOVA test was applied; for nonparametric  data, the Kruskal-Wallis test was used. All measurements were performed at least in triplicate, and data were expressed as mean ± standard  error of the mean (SEM). Statistical significance (*) was considered to be achieved when p &lt; 0.05. The 3D protein structure.
description: MS Excel, null
DOI: 10.5517/cc1j74mj
title: CCDC 1407047: Experimental Crystal Structure Determination

description: Related Article: Yichen Wu, Ismael Arenas, Lewis Marc Broomfield, Eddy Martin, Alexandr Shafir|2015|Chem.-Eur.J.|21|18779|doi:10.1002/chem.201503987
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1j74nk
title: CCDC 1407048: Experimental Crystal Structure Determination

description: Related Article: Yichen Wu, Ismael Arenas, Lewis Marc Broomfield, Eddy Martin, Alexandr Shafir|2015|Chem.-Eur.J.|21|18779|doi:10.1002/chem.201503987
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzk57
title: CCDC 1429539: Experimental Crystal Structure Determination

description: Related Article: Yichen Wu, Ismael Arenas, Lewis Marc Broomfield, Eddy Martin, Alexandr Shafir|2015|Chem.-Eur.J.|21|18779|doi:10.1002/chem.201503987
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzk9c
title: CCDC 1429543: Experimental Crystal Structure Determination

description: Related Article: Alexander S. Henderson,  Sandra Medina,  John F. Bower,  and M. Carmen Galan|2015|Org.Lett.|17|4846|doi:10.1021/acs.orglett.5b02413
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lkgq
title: CCDC 1030733: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lkhr
title: CCDC 1030734: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lk8j
title: CCDC 1030727: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lk9k
title: CCDC 1030728: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lkbl
title: CCDC 1030729: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lkcm
title: CCDC 1030730: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lkdn
title: CCDC 1030731: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13lkfp
title: CCDC 1030732: Experimental Crystal Structure Determination

description: Related Article: Szymon Sobczak, Andrzej Katrusiak|2015|Cryst.Growth Des.|15|5530|doi:10.1021/acs.cgd.5b01156
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkbd
title: CCDC 1429544: Experimental Crystal Structure Determination

description: Related Article: Venkata R. Sabbasani and Daesung Lee|2015|Org.Lett.|17|4878|doi:10.1021/acs.orglett.5b02433
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkcf
title: CCDC 1429545: Experimental Crystal Structure Determination

description: Related Article: Venkata R. Sabbasani and Daesung Lee|2015|Org.Lett.|17|4878|doi:10.1021/acs.orglett.5b02433
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkdg
title: CCDC 1429546: Experimental Crystal Structure Determination

description: Related Article: Koichi Mitsudo,  Hidehiko Sato,  Arata Yamasaki,  Natsuyo Kamimoto,  Jun Goto,  Hiroki Mandai,  and Seiji Suga|2015|Org.Lett.|17|4858|doi:10.1021/acs.orglett.5b02417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkfh
title: CCDC 1429547: Experimental Crystal Structure Determination

description: Related Article: Koichi Mitsudo,  Hidehiko Sato,  Arata Yamasaki,  Natsuyo Kamimoto,  Jun Goto,  Hiroki Mandai,  and Seiji Suga|2015|Org.Lett.|17|4858|doi:10.1021/acs.orglett.5b02417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkgj
title: CCDC 1429548: Experimental Crystal Structure Determination

description: Related Article: Koichi Mitsudo,  Hidehiko Sato,  Arata Yamasaki,  Natsuyo Kamimoto,  Jun Goto,  Hiroki Mandai,  and Seiji Suga|2015|Org.Lett.|17|4858|doi:10.1021/acs.orglett.5b02417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkhk
title: CCDC 1429549: Experimental Crystal Structure Determination

description: Related Article: Koichi Mitsudo,  Hidehiko Sato,  Arata Yamasaki,  Natsuyo Kamimoto,  Jun Goto,  Hiroki Mandai,  and Seiji Suga|2015|Org.Lett.|17|4858|doi:10.1021/acs.orglett.5b02417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkjl
title: CCDC 1429550: Experimental Crystal Structure Determination

description: Related Article: Koichi Mitsudo,  Hidehiko Sato,  Arata Yamasaki,  Natsuyo Kamimoto,  Jun Goto,  Hiroki Mandai,  and Seiji Suga|2015|Org.Lett.|17|4858|doi:10.1021/acs.orglett.5b02417
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jd5fj
title: CCDC 1411877: Experimental Crystal Structure Determination

description: Related Article: David A. Petrone,  Andy Yen,  Nicolas Zeidan,  and Mark Lautens|2015|Org.Lett.|17|4838|doi:10.1021/acs.orglett.5b02403
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jd5gk
title: CCDC 1411878: Experimental Crystal Structure Determination

description: Related Article: David A. Petrone,  Andy Yen,  Nicolas Zeidan,  and Mark Lautens|2015|Org.Lett.|17|4838|doi:10.1021/acs.orglett.5b02403
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jd5hl
title: CCDC 1411879: Experimental Crystal Structure Determination

description: Related Article: David A. Petrone,  Andy Yen,  Nicolas Zeidan,  and Mark Lautens|2015|Org.Lett.|17|4838|doi:10.1021/acs.orglett.5b02403
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.17425931
title: Basic input data for the HELIOS atmosphere model

description: The zip-file contains the basic input data for the HELIOS atmosphere model. It was previously created by Matej Malik and hosted at a server of the University of Bern. Since this server is no longer online, the data is now available on Zenodo. No changes have been made to the orginal data release from 2022. The code itself is still available on GitHub: https://github.com/exoclime/HELIOS
DOI: 10.5281/zenodo.17425932
title: Basic input data for the HELIOS atmosphere model

description: The zip-file contains the basic input data for the HELIOS atmosphere model. It was previously created by Matej Malik and hosted at a server of the University of Bern. Since this server is no longer online, the data is now available on Zenodo. No changes have been made to the orginal data release from 2022. The code itself is still available on GitHub: https://github.com/exoclime/HELIOS
DOI: 10.5517/cc13sk4l
title: CCDC 1036489: Experimental Crystal Structure Determination

description: Related Article: Wenduan Hou,  Qi Wei,  Guisheng Liu,  Jing Chen,  Jing Guo,  and Yungui Peng|2015|Org.Lett.|17|4870|doi:10.1021/acs.orglett.5b02423
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzrbl
title: CCDC 1429730: Experimental Crystal Structure Determination

description: Related Article: David A. Petrone,  Andy Yen,  Nicolas Zeidan,  and Mark Lautens|2015|Org.Lett.|17|4838|doi:10.1021/acs.orglett.5b02403
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc13sk3k
title: CCDC 1036488: Experimental Crystal Structure Determination

description: Related Article: Wenduan Hou,  Qi Wei,  Guisheng Liu,  Jing Chen,  Jing Guo,  and Yungui Peng|2015|Org.Lett.|17|4870|doi:10.1021/acs.orglett.5b02423
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc142108
title: CCDC 1044638: Experimental Crystal Structure Determination

description: Related Article: Wenduan Hou,  Qi Wei,  Guisheng Liu,  Jing Chen,  Jing Guo,  and Yungui Peng|2015|Org.Lett.|17|4870|doi:10.1021/acs.orglett.5b02423
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc1jzkkm
title: CCDC 1429551: Experimental Crystal Structure Determination

description: Related Article: Guisheng Deng,  Feng Wang,  Shengle Lu,  and Bo Cheng|2015|Org.Lett.|17|4651|doi:10.1021/acs.orglett.5b02369
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jzkln
title: CCDC 1429552: Experimental Crystal Structure Determination

description: Related Article: Andrzej Błauż, Błażej Rychlik, Anna Makal, Katarzyna Szulc, Paweł Strzelczyk, Grzegorz Bujacz, Janusz Zakrzewski, Krzysztof Woźniak, Damian Plażuk|2016|ChemPlusChem|81|1191|doi:10.1002/cplu.201600320
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jzkmp
title: CCDC 1429553: Experimental Crystal Structure Determination

description: Related Article: Andrzej Błauż, Błażej Rychlik, Anna Makal, Katarzyna Szulc, Paweł Strzelczyk, Grzegorz Bujacz, Janusz Zakrzewski, Krzysztof Woźniak, Damian Plażuk|2016|ChemPlusChem|81|1191|doi:10.1002/cplu.201600320
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jzknq
title: CCDC 1429554: Experimental Crystal Structure Determination

description: Related Article: Andrzej Błauż, Błażej Rychlik, Anna Makal, Katarzyna Szulc, Paweł Strzelczyk, Grzegorz Bujacz, Janusz Zakrzewski, Krzysztof Woźniak, Damian Plażuk|2016|ChemPlusChem|81|1191|doi:10.1002/cplu.201600320
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jzkpr
title: CCDC 1429555: Experimental Crystal Structure Determination

description: Related Article: Andrzej Błauż, Błażej Rychlik, Anna Makal, Katarzyna Szulc, Paweł Strzelczyk, Grzegorz Bujacz, Janusz Zakrzewski, Krzysztof Woźniak, Damian Plażuk|2016|ChemPlusChem|81|1191|doi:10.1002/cplu.201600320
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1jzkqs
title: CCDC 1429556: Experimental Crystal Structure Determination

description: Related Article: Andrzej Błauż, Błażej Rychlik, Anna Makal, Katarzyna Szulc, Paweł Strzelczyk, Grzegorz Bujacz, Janusz Zakrzewski, Krzysztof Woźniak, Damian Plażuk|2016|ChemPlusChem|81|1191|doi:10.1002/cplu.201600320
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.