cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc1p5yyr
title: CCDC 1554865: Experimental Crystal Structure Determination

description: Related Article: Atsushi Fujiwara, Yusuke Inagaki, Hiroyuki Momma, Eunsang Kwon, Kentaro Yamaguchi, Manabu Kanno, Hirohiko Kono, Wataru Setaka|2017|CrystEngComm|19|6049|doi:10.1039/C7CE01081H
description: Related Article: Wataru Setaka|2017|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5yzs
title: CCDC 1554866: Experimental Crystal Structure Determination

description: Related Article: Atsushi Fujiwara, Yusuke Inagaki, Hiroyuki Momma, Eunsang Kwon, Kentaro Yamaguchi, Manabu Kanno, Hirohiko Kono, Wataru Setaka|2017|CrystEngComm|19|6049|doi:10.1039/C7CE01081H
description: Related Article: Wataru Setaka|2017|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m3a0xatchk
title: Immune responses to fetal surgery

description: Fetal surgery for spina bifida repair improves infant outcomes; however, spontaneous preterm birth (sPTB) is common. We aimed to evaluate maternal immune responses following FS for SB repair.
DOI: 10.21430/m3xnzulswc
title: SAM COBRA vaccine antibody response to influenza

description: Healthy mice and ferrets were vaccinated with self-amplifying mRNA (SAM) vaccines that express COBRA HA proteins. The SAM acts as an amplifying mechanism for the vaccine to elicit a higher antibody response.
DOI: 10.5517/ccdc.csd.cc1p5z2x
title: CCDC 1554869: Experimental Crystal Structure Determination

description: Related Article: Wenqian Shan, Valentin Quesneau, Nicolas Desbois, Virginie Blondeau-Patissier, Mario L. Naitana, Yoann Rousselin, Claude P. Gros, Zhongping Ou, Karl M. Kadish|2019|J.Porphyrins Phthalocyanines|23|213|doi:10.1142/S1088424619500214
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5z61
title: CCDC 1554873: Experimental Crystal Structure Determination

description: Related Article: Fengjuan Chen, Yajun Wang, Shijun Zhao, Wei Jiang, Congde Huo|2017|Org.Biomol.Chem.|15|7710|doi:10.1039/C7OB01859B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5z72
title: CCDC 1554874: Experimental Crystal Structure Determination

description: Related Article: Debanjana Biswal, Nikhil Ranjan Pramanik, Syamal Chakrabarti, Michael G. B. Drew, Krishnendu Acharya, Swarnendu Chandra|2017|Dalton Trans.|46|16682|doi:10.1039/C7DT02903A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m349w2ir3x
title: A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins

description: This study assessed a low-dose inactivated split virus vaccine derived from clade 2.3.4.4b H5N1, formulated with an Alum/CpG adjuvant, using a preclinical mouse model.
DOI: 10.5517/ccdc.csd.cc1p5z83
title: CCDC 1554875: Experimental Crystal Structure Determination

description: Related Article: Debanjana Biswal, Nikhil Ranjan Pramanik, Syamal Chakrabarti, Michael G. B. Drew, Krishnendu Acharya, Swarnendu Chandra|2017|Dalton Trans.|46|16682|doi:10.1039/C7DT02903A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5z94
title: CCDC 1554876: Experimental Crystal Structure Determination

description: Related Article: Debanjana Biswal, Nikhil Ranjan Pramanik, Syamal Chakrabarti, Michael G. B. Drew, Krishnendu Acharya, Swarnendu Chandra|2017|Dalton Trans.|46|16682|doi:10.1039/C7DT02903A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m35tfihi2j
title: Long-lasting B cell convergence to broadly reactive epitopes after chimeric HA vaccination

description: The authors determine the specificity/function of B cells induced by cHA vaccination
DOI: 10.21430/m3id11r70i
title: Comparisons of CD4+ T cells, serological responses and antibody titers against SARS-CoV-2 Variants

description: To analyze how immune responses compare among ethnic groups following a third COVID-19 vaccine dose, approximately two years later.
DOI: 10.5517/ccdc.csd.cc1nb3ps
title: CCDC 1529065: Experimental Crystal Structure Determination

description: Related Article: Nandita Sarkar, Klaus Harms, Antonio Frontera, Shouvik Chattopadhyay|2017|New J.Chem.|41|8053|doi:10.1039/C7NJ00766C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5zb5
title: CCDC 1554877: Experimental Crystal Structure Determination

description: Related Article: Sílvia Alujas-Burgos,  Cristina Oliveras-González,  Ángel Álvarez-Larena,  Pau Bayón,  and Marta Figueredo|2018|J.Org.Chem.|83|5052|doi:10.1021/acs.joc.8b00390
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m3s66dbqcc
title: An early burst of IL-2 synthesis influences CD8 T cell fates

description: The differentiation of CD8 T cells into effector and memory populations is guided by a combination of antigenic, costimulatory, and cytokine signals. Here we show that, within 24 hours of activating naïve CD8 T cells, populations emerge with divergent patterns of IL-2 and IFN-g synthesis. This rapid, dynamic, and heterogeneous burst of cytokine production manifests with every CD8 T cell specificity analyzed, is apparent in vivo and in vitro, and occurs prior to the first cell division. Nevertheless, how the intrinsic manufacture of distinct cytokines forecasts and influences the properties and fates of the producer cell itself are not well defined. We demonstrate that the initial cell intrinsic synthesis of IL-2 attenuates IL-2-dependent STAT5 signaling, but that this is not due to differences in the surface expression of the IL-2 receptor complex. The functionally discrete subsets are transcriptionally distinct and display differences in the expression of hallmark effector and memory associated genes. Using cytokine reporter systems, we reveal that these early functional differences are consequential for establishing fate biases and directing the gain of effector and memory T cell properties. The bifurcation between the abilities of IL-2-producing and non-producing subsets to elaborate STAT5 signaling is consistent with a model in which non-IL-2-producing CD8 T cells are more receptive to extrinsic IL-2 signals and preferentially contribute to the early surge of effector formation. Despite this, both IL-2-producing and non-producing CD8 T cells can go on to acquire memory traits, indicating that there is developmental diversity within each cytokine producing subset.
DOI: 10.5517/ccdc.csd.cc1nb3qt
title: CCDC 1529066: Experimental Crystal Structure Determination

description: Related Article: Nandita Sarkar, Klaus Harms, Antonio Frontera, Shouvik Chattopadhyay|2017|New J.Chem.|41|8053|doi:10.1039/C7NJ00766C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m3aw1a5e9x
title: Analysis of CK1 inhibition effects on immune system in healthy and CLL-bearing mice

description: Casein kinase 1 (CK1) has been proved as an efficient approach in the treatment of chronic lymphocytic leukemia (CLL), as this therapeutic strategy led to longer overall survival and scarcer relapse in Eµ-TCL1 adoptive transfer (AT) mouse model. In this study, we aimed to find out whether the CK1 inhibition modulates the microenvironment of CLL in vivo and in what favor. Thus, we conducted several in vivo experiments on both healthy and CLL-bearing mice that were all terminated by multiparametric flow cytometric analysis of selected immune cell populations in 4 different types of microenvironment, including peripheral blood (PB), lymph nodes (LN), spleen (SPL) and bone marrow (BM).
DOI: 10.5517/ccdc.csd.cc1p5ztn
title: CCDC 1554892: Experimental Crystal Structure Determination

description: Related Article: Koji Takagi, Kaede Ito, Yoshihiro Yamada, Takuya Nakashima, Ryoichi Fukuda, Masahiro Ehara, Daisuke Takeuchi|2017|Chem.Lett.|46|1372|doi:10.1246/cl.170569
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5zvp
title: CCDC 1554893: Experimental Crystal Structure Determination

description: Related Article: Koji Takagi, Kaede Ito, Yoshihiro Yamada, Takuya Nakashima, Ryoichi Fukuda, Masahiro Ehara, Daisuke Takeuchi|2017|Chem.Lett.|46|1372|doi:10.1246/cl.170569
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m38w4kxgpp
title: Analysis of the response of in vitro proliferating CLL patient cells to CK1 inhibition

description: Casein kinase 1 (CK1) has been proved as an efficient approach in the treatment of chronic lymphocytic leukemia (CLL), as this therapeutic strategy led to longer overall survival and scarcer relapse in Eµ-TCL1 adoptive transfer (AT) mouse model. In this study, we aimed to further characterize what mechanism makes CK1 inhibition efficient in counteracting the CLL progression. In particular, we performed bulk RNA sequencing on splenic CLL cells from in vivo treated Eµ-TCL1 AT mice which led us to a hypothesis that CK1 inhibition delays the cell cycle progression of the CLL cells by accumulation of cells at the S/G2 interface. To be able to test whether this mechanism might lead to actual attenuation of primary CLL cells, we utilized an established protocol that uses CD40L-expressing HS5 stromal cells in combination with soluble interleukin (IL-) 4 and IL-21 where we (at the same time) tested the efficacy of CK1 inhibition in suppression of the in vitro stimulated proliferation boost. This helped us to test intrinsic and microenvironmental aspect of the mechanism-of-action of the CK1 inhibition in one well. The provided data are a result of the 6 day in vitro co-culture of primary CLL cells with the CD40L+ HS5 stromal cells along with the treatment (for more information, see the protocol or the attached publications). We next gathered used multiple clinical parameters to further characterize the resistant group of sanples and correlate the response to the known clinical parameters. All samples from the peripheral blood of the CLL patients were taken after signature of informed consent approved by the Ethical Committee of the University Hospital Brno in accordance with the Declaration of Helsinki.
DOI: 10.5517/ccdc.csd.cc1p5zxr
title: CCDC 1554895: Experimental Crystal Structure Determination

description: Related Article: Zandria Lamprecht, Shankara G. Radhakrishnan, Alexander Hildebrandt, Heinrich Lang, David C. Liles, Nora-ann Weststrate, Simon Lotz, Daniela I. Bezuidenhout|2017|Dalton Trans.|46|13983|doi:10.1039/C7DT02969A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p5zys
title: CCDC 1554896: Experimental Crystal Structure Determination

description: Related Article: Zandria Lamprecht, Shankara G. Radhakrishnan, Alexander Hildebrandt, Heinrich Lang, David C. Liles, Nora-ann Weststrate, Simon Lotz, Daniela I. Bezuidenhout|2017|Dalton Trans.|46|13983|doi:10.1039/C7DT02969A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m37xjesoqj
title: Flow cytometric analysis of NFκB in primary CLL cells upon co-culture with M2-10B4 stromal cells

description: Casein kinase 1 (CK1) has been proved as an efficient approach in the treatment of chronic lymphocytic leukemia (CLL). In this study, we aimed to describe the mechanism-of-action of the CK1 inhibition on the primary CLL cells that were due to their low viability in vitro stimulated by co-culture with M2-10B4 stromal cells that provide activation stimuli mimicking the microenvironment of the lymph nodes (LN). Based on our RNAseq experiment originating from this co-culture model, we were able to see significant downregulation of multiple activation-related pathways in the CLL cells upon CK1 inhibition, including NFκB signalling pathway. Due to this effect on gene expression level, we wanted to inspect whether the NFκB is downregulated also on the protein level. Thus, we utilized the same experimental design with the flow cytometric detection of intracellular NFκB in primary CLL cells that was performed at the endpoint. The provided FCS files originate from 7 CLL patient samples which underwent this experimental set-up with the flow cytometry-oriented endpoint. All samples from the peripheral blood of the CLL patients were taken after signature of informed consent approved by the Ethical Committee of the University Hospital Brno in accordance with the Declaration of Helsinki.
DOI: 10.5517/ccdc.csd.cc1p5zzt
title: CCDC 1554897: Experimental Crystal Structure Determination

description: Related Article: Zandria Lamprecht, Shankara G. Radhakrishnan, Alexander Hildebrandt, Heinrich Lang, David C. Liles, Nora-ann Weststrate, Simon Lotz, Daniela I. Bezuidenhout|2017|Dalton Trans.|46|13983|doi:10.1039/C7DT02969A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m3udkb7yi5
title: Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages

description: Immunological memory elicited either through previous or ongoing M. tuberculosis (Mtb) infection provides a critical mechanism by which hosts protect against re-infection and disease progression upon Mtb re-exposure. Conversely, the global circulation of—and uneven competition between—distinct Mtb strains suggest certain bacterial clades are able to better spread across communities, potentially by evading memory responses gained by prior infection with genomically different strains. To address this question, we conducted a heterologous reinfection study in cynomolgus macaques involving primary infection by a Lineage 4 Erdman Mtb strain and subsequent re-infection by a Lineage 2 strain (L2-HT), which belongs to a clade that has been epidemiologically shown to be successfully spreading over the last decade in Lima, Peru cohort. Here, through microbiologic, PET-CT and sequencing of Mtb genomic barcodes, we show that reinfected animals developed fewer lung lesions and controlled both pulmonary and disseminated forms of disease better than naïve animals that have had no prior exposure to Mtb. Thus, protection against reinfection is not limited by Mtb lineage, providing optimism that vaccines can be effective across populations and geographic locations.
DOI: 10.5517/ccdc.csd.cc1p600x
title: CCDC 1554898: Experimental Crystal Structure Determination

description: Related Article: Zandria Lamprecht, Shankara G. Radhakrishnan, Alexander Hildebrandt, Heinrich Lang, David C. Liles, Nora-ann Weststrate, Simon Lotz, Daniela I. Bezuidenhout|2017|Dalton Trans.|46|13983|doi:10.1039/C7DT02969A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p601y
title: CCDC 1554899: Experimental Crystal Structure Determination

description: Related Article: Zandria Lamprecht, Shankara G. Radhakrishnan, Alexander Hildebrandt, Heinrich Lang, David C. Liles, Nora-ann Weststrate, Simon Lotz, Daniela I. Bezuidenhout|2017|Dalton Trans.|46|13983|doi:10.1039/C7DT02969A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m3zd77ycie
title: TLR4 or TLR7/8 agonists adjuvanted COBRA HA vaccines

description: Mice vaccinated with HA COBRA vaccines with different TLR agonists in various formulations to evaluate the protective efficacy against influenza viruses and the elicited immune responses.
DOI: 10.5517/ccdc.csd.cc1p602z
title: CCDC 1554900: Experimental Crystal Structure Determination

description: Related Article: Zandria Lamprecht, Shankara G. Radhakrishnan, Alexander Hildebrandt, Heinrich Lang, David C. Liles, Nora-ann Weststrate, Simon Lotz, Daniela I. Bezuidenhout|2017|Dalton Trans.|46|13983|doi:10.1039/C7DT02969A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p6052
title: CCDC 1554903: Experimental Crystal Structure Determination

description: Related Article: Debdeep Mandal,  Ramapada Dolai,  Nicolas Chrysochos,  Pankaj Kalita,  Ravi Kumar,  Debabrata Dhara,  Avijit Maiti,  Ramakirushnan Suriya Narayanan,  Gopalan Rajaraman,  Carola Schulzke,  Vadapalli Chandrasekhar,  and Anukul Jana|2017|Org.Lett.|19|5605|doi:10.1021/acs.orglett.7b02721
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21430/m3l93kep44
title: Group 1 and group 2 hemagglutinin stalk antibody response according to age

description: The authors investigate the induction of HA stalk-specific antibodies after seasonal influenza vaccination, considering the age of the cohorts.
DOI: 10.5517/ccdc.csd.cc1p6063
title: CCDC 1554904: Experimental Crystal Structure Determination

description: Related Article: Debdeep Mandal,  Ramapada Dolai,  Nicolas Chrysochos,  Pankaj Kalita,  Ravi Kumar,  Debabrata Dhara,  Avijit Maiti,  Ramakirushnan Suriya Narayanan,  Gopalan Rajaraman,  Carola Schulzke,  Vadapalli Chandrasekhar,  and Anukul Jana|2017|Org.Lett.|19|5605|doi:10.1021/acs.orglett.7b02721
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1p6096
title: CCDC 1554907: Experimental Crystal Structure Determination

description: Related Article: Debdeep Mandal,  Ramapada Dolai,  Nicolas Chrysochos,  Pankaj Kalita,  Ravi Kumar,  Debabrata Dhara,  Avijit Maiti,  Ramakirushnan Suriya Narayanan,  Gopalan Rajaraman,  Carola Schulzke,  Vadapalli Chandrasekhar,  and Anukul Jana|2017|Org.Lett.|19|5605|doi:10.1021/acs.orglett.7b02721
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.