cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9900194.v1
title: Lean Production in small and medium sized companies from the Free Economic Zone of Manaus: a reality or just fiction?

description: Abstract Given the current market demands, small and medium-sized enterprises (SMEs) are under pressure to change their working methods, implying changes in concepts and practices in order to improve their production systems and processes. Thus, the search for production methodologies, techniques and tools becomes urgent and imperative. One way to achieve this goal is to adopt the Lean Production (LP) methodology. This document presents the results of a survey, developed in the north of Brazil, involving 75 SMEs from the free economic zone of Manaus to assess the degree of LP implementation. The results showed a limited implementation of LP. Moreover, palliative practices (momentary relief), hopeful implementations and impediment factors are common. Attending to these results, the authors are tempted to say that LP is still a fiction for SMEs in this region.
DOI: 10.6084/m9.figshare.9900182
title: Chymotrypsin- and trypsin-like activities secreted by the multidrug-resistant yeasts forming the Candida haemulonii complex

description: Abstract: Candida haemulonii complex (C. haemulonii, C. haemulonii var. vulnera and C. duobushaemulonii) consists of emergent multidrug-resistant pathogens that cause bloodstream and deep-seated infections. However, little is known about their virulence factors. Herein, we evaluated the presence of extracellular serine peptidases in this fungal complex. Serine peptidase activity was measured by spectrophotometry using chromogenic peptide substrates to the S1 family. Chymotrypsin-, trypsin- and elastase-like activities were detected in all fungal isolates. Since higher chymotrypsin- and trypsin-like activities were observed from the cleavage of N-succinyl-Ala-Ala-Pro-Phe-pNa and N-benzoyl-Phe-Val-Arg-pNa, respectively, these substrates were selected for further experiments. Overall, pHs 7.0 and 9.0 were those in which higher chymotrypsin- and trypsin-like activities were observed, respectively, displaying higher hydrolytic activities at 37-45°C. Additionally, the serine peptidases produced by C. haemulonii complex were inhibited by PMSF and AEBSF in a typically concentration-dependent manner. Although the Michaelis constant (Km) values obtained for chymotrypsin-like peptidases were similar, greater differences were observed for trypsin-like enzymes secreted by the different fungal isolates. This is the first time that peptidases belonging to the S1 family are described in the C. haemulonii species complex. Thus, these data open the doors for more detailed studies into potential roles of these peptidases in fungal virulence.
DOI: 10.6084/m9.figshare.9900185
title: A PRINCIPLE OF PREFERENCE CONCENTRATION APPLIED TO THE UNSUPERVISED EVALUATION OF THE IMPORTANCE OF MULTIPLE CRITERIA

description: ABSTRACT The influence of a principle of preference concentration in the process of decision making in different contexts is discussed here. A procedure exploring the concentration of preferences to derive probabilities and another to derive, with higher generality, Choquet capacities are presented. An important feature of this last procedure is that it derives capacities in a space of criteria only from matrices of probabilities of preference according to each criterion, precluding the effort of directly trying to measure the interactions between them.
DOI: 10.6084/m9.figshare.9900188.v1
title: Regional deindustrialization: concepts, causes, effects and the Brazilian case

description: Abstract This paper aims to analyze the process of deindustrialization of the Brazilian economy from a regional perspective. Since the mid-2000s there has been an intense debate about the process of deindustrialization in the Brazilian economy, obtaining significant advances in the causes, consequences and, especially, the emphasis given to the role of industry in the development of Brazil. However, the deindustrialization in the Brazilian economy is treated in a homogeneous way, so that the discussion in the regional perspective is practically disregarded. This paper attempts to reduce this debate gap in the sense that it develops concepts appropriate to the regional space and explains its causes.
DOI: 10.6084/m9.figshare.9900179
title: Screening for FMR1 expanded alleles in patients with Autism Spectrum Disorders in Manaus, Northern Brazil

description: Abstract: Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by dynamic mutations of a CGG repetition segment in an X chromosome’s single gene. It is considered the leading hereditary cause of both Autism Spectrum Disorders and Intellectual Disability. Some authors suggest that all individuals diagnosed with some of these latter conditions to be clinically and molecularly trialled for FXS due to the high levels of comorbidity between both conditions and also due to the variable expressiveness of this syndrome. This study has focused on verifying the presence of FMR1 expanded alleles since there is a lack of information about this kind of mutation in autism patients from the northern region of Brazil. The presence of large alleles for this gene could offer new therapeutic or pharmacological methods for the treatment of these patients. Both the presence and the frequency of CGG expansions were verified in 90 autism males by molecular analysis. Four of them had intermediate alleles and four others presented premutated alleles. Premutation carriers are on the propensity of developing the late onset Fragile X-associated tremor/ataxia syndrome. No full mutation alleles were found. Further studies are necessary to obtain more accurate statistical data about this kind of dynamic mutation.
DOI: 10.6084/m9.figshare.9900182.v1
title: Chymotrypsin- and trypsin-like activities secreted by the multidrug-resistant yeasts forming the Candida haemulonii complex

description: Abstract: Candida haemulonii complex (C. haemulonii, C. haemulonii var. vulnera and C. duobushaemulonii) consists of emergent multidrug-resistant pathogens that cause bloodstream and deep-seated infections. However, little is known about their virulence factors. Herein, we evaluated the presence of extracellular serine peptidases in this fungal complex. Serine peptidase activity was measured by spectrophotometry using chromogenic peptide substrates to the S1 family. Chymotrypsin-, trypsin- and elastase-like activities were detected in all fungal isolates. Since higher chymotrypsin- and trypsin-like activities were observed from the cleavage of N-succinyl-Ala-Ala-Pro-Phe-pNa and N-benzoyl-Phe-Val-Arg-pNa, respectively, these substrates were selected for further experiments. Overall, pHs 7.0 and 9.0 were those in which higher chymotrypsin- and trypsin-like activities were observed, respectively, displaying higher hydrolytic activities at 37-45°C. Additionally, the serine peptidases produced by C. haemulonii complex were inhibited by PMSF and AEBSF in a typically concentration-dependent manner. Although the Michaelis constant (Km) values obtained for chymotrypsin-like peptidases were similar, greater differences were observed for trypsin-like enzymes secreted by the different fungal isolates. This is the first time that peptidases belonging to the S1 family are described in the C. haemulonii species complex. Thus, these data open the doors for more detailed studies into potential roles of these peptidases in fungal virulence.
DOI: 10.6084/m9.figshare.9900185.v1
title: A PRINCIPLE OF PREFERENCE CONCENTRATION APPLIED TO THE UNSUPERVISED EVALUATION OF THE IMPORTANCE OF MULTIPLE CRITERIA

description: ABSTRACT The influence of a principle of preference concentration in the process of decision making in different contexts is discussed here. A procedure exploring the concentration of preferences to derive probabilities and another to derive, with higher generality, Choquet capacities are presented. An important feature of this last procedure is that it derives capacities in a space of criteria only from matrices of probabilities of preference according to each criterion, precluding the effort of directly trying to measure the interactions between them.
DOI: 10.6084/m9.figshare.9900170
title: Purple urine bag syndrome: case report

description: ABSTRACT A 65-year-old male with a history of urinary tract trauma requiring cystotomy and chronic bladder catheterization, presenting with chronic and uninvestigated changes in the color of the urine bag system, with no urine color change, and positive urine culture for Proteus mirabilis . These characteristics refer to the purple urine bag syndrome, a not weel-known condition, with a benign course in most cases, and associated with urinary tract infection in patients with chronic bladder catheterization. Although it is characterized by marked changes, it is underdiagnosed by healthcare professionals.
DOI: 10.6084/m9.figshare.9900173
title: Pressures from the context and institutional capacity building to develop industrial symbiosis networks

description: Abstract This research analyzes the importance of the institutional and economic context and the institutional capacity building to develop an industrial symbiosis networks through the “Programa Mineiro de Simbiose Industrial” (PMSI). The research is qualitative, exploratory and descriptive, using content analysis techniques. Interviews were conducted with managers and government actors with active PMSI participation. The institutional and economic contexts and the current knowledge, mobilization and relational capacities were identified. The results indicate that the industrial symbiosis network is not dense and there are few waste exchanges among companies. There is an effort among actors who participate in the PMSI to build knowledge, mobilization and relationship capacities. However, the institutional context is unfavorable to the development of industrial symbiosis. This study article reinforces the need to invest in eco-innovative solutions and institutional environment improvements to develop efficient natural resources and waste management, and thus allow the development of eco-industrial parks.
DOI: 10.6084/m9.figshare.9900176
title: Development of a managerial tool for prioritization and selection of portfolio projects using the Analytic Hierarchy Process methodology in software companies

description: Abstract This study presents a managerial tool for prioritization and portfolio selection of software development projects using the methodology Analytic Hierarchy Process (AHP). The need for better results with scarce resources is a challenge for organizations to generate competitive advantage. The tool is structured according to the analysis of articles related to project prioritization and selection, portfolio management and the AHP methodology. The research approach was quantitative through an applied case study. The case was developed in a medium-sized software company in Santa Catarina, a leader in solutions for management excellence, provider of software and services for automation and business process improvement, regulatory compliance, and corporate governance. It has more than 2000 clients, of diverse sizes and lines of action. A committee was set up with managers and analysts to define the groups and criteria, and the application of a pilot of projects. There were opportunities to use this managerial tool to minimize power play, integration, information sharing, learning, commitment among decision makers and selection of strategically aligned projects.
DOI: 10.6084/m9.figshare.9900179.v1
title: Screening for FMR1 expanded alleles in patients with Autism Spectrum Disorders in Manaus, Northern Brazil

description: Abstract: Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by dynamic mutations of a CGG repetition segment in an X chromosome’s single gene. It is considered the leading hereditary cause of both Autism Spectrum Disorders and Intellectual Disability. Some authors suggest that all individuals diagnosed with some of these latter conditions to be clinically and molecularly trialled for FXS due to the high levels of comorbidity between both conditions and also due to the variable expressiveness of this syndrome. This study has focused on verifying the presence of FMR1 expanded alleles since there is a lack of information about this kind of mutation in autism patients from the northern region of Brazil. The presence of large alleles for this gene could offer new therapeutic or pharmacological methods for the treatment of these patients. Both the presence and the frequency of CGG expansions were verified in 90 autism males by molecular analysis. Four of them had intermediate alleles and four others presented premutated alleles. Premutation carriers are on the propensity of developing the late onset Fragile X-associated tremor/ataxia syndrome. No full mutation alleles were found. Further studies are necessary to obtain more accurate statistical data about this kind of dynamic mutation.
DOI: 10.6084/m9.figshare.9900176.v1
title: Development of a managerial tool for prioritization and selection of portfolio projects using the Analytic Hierarchy Process methodology in software companies

description: Abstract This study presents a managerial tool for prioritization and portfolio selection of software development projects using the methodology Analytic Hierarchy Process (AHP). The need for better results with scarce resources is a challenge for organizations to generate competitive advantage. The tool is structured according to the analysis of articles related to project prioritization and selection, portfolio management and the AHP methodology. The research approach was quantitative through an applied case study. The case was developed in a medium-sized software company in Santa Catarina, a leader in solutions for management excellence, provider of software and services for automation and business process improvement, regulatory compliance, and corporate governance. It has more than 2000 clients, of diverse sizes and lines of action. A committee was set up with managers and analysts to define the groups and criteria, and the application of a pilot of projects. There were opportunities to use this managerial tool to minimize power play, integration, information sharing, learning, commitment among decision makers and selection of strategically aligned projects.
DOI: 10.6084/m9.figshare.9900167
title: Concentrated beta-galactosidase and cell permeabilization from Saccharomyces fragilis IZ 275 for beta-galactosidase activity in the hydrolysis of lactose

description: Abstract The cheese whey shows an organic nutrient charge that can be used to obtain metabolites of interest by biotechnology of microorganisms. Thus, fermentative processes for enzyme production, in particular beta-galactosidase becomes feasible. The enzyme plays an important role in the biotech food industry to obtain milk and dairy products with low lactose content for consumption by intolerant individuals. The objective of this work was to determine the enzyme activity of the concentrated beta-galactosidase (CBG) and the permeabilized cells (PC) both obtained from Saccharomyces fragilis IZ 275. The enzyme beta-galactosidase obtained from the fermentation of Saccharomyces fragilis IZ 275 in cheese whey was used to determine the optimal conditions for the hydrolysis of lactose solution at 1% (w/v). Response Surface Methodology (RSM) by Box-Behnken Design (BBD) was employed to determine beta-galactosidase activity for such factors pH, temperature and enzyme concentration suitable for the lactose hydrolysis. Based on the statistical analysis, the optimum operational conditions for maximizing lactose hydrolysis thus optimizing the enzyme activity for CBG were, temperature 30 °C, pH 6.0 and enzyme concentration 3% (v/v) and for PC was temperature 44 °C, pH 7.0 and enzyme concentration 4% (v/v).
DOI: 10.6084/m9.figshare.9900170.v1
title: Purple urine bag syndrome: case report

description: ABSTRACT A 65-year-old male with a history of urinary tract trauma requiring cystotomy and chronic bladder catheterization, presenting with chronic and uninvestigated changes in the color of the urine bag system, with no urine color change, and positive urine culture for Proteus mirabilis . These characteristics refer to the purple urine bag syndrome, a not weel-known condition, with a benign course in most cases, and associated with urinary tract infection in patients with chronic bladder catheterization. Although it is characterized by marked changes, it is underdiagnosed by healthcare professionals.
DOI: 10.6084/m9.figshare.9900161
title: Case study: influence of performance levels of ABNT NBR 15575 without consumption of materials used in reinforced concrete structures

description: Abstract The Brazilian construction industry still discusses the consequence of the Performance Standard on housing developments. According to ABNT NBR 15575 [1], the systems that compose residential buildings need to meet minimum performance requirements. Among the systems, the structural must reach a minimum Service Life (SL) of 50 years, or intermediate or higher that corresponds to 63 and 75 years, respectively. The industry also debates the impact and viability of increasing the SL of reinforced concrete structures. Therefore, this article aimed to analyze a single reinforced concrete building designed for the 3 SL specified by ABNT NBR 15575 [1]. The study focused on the total consumption of steel and concrete. The structure’s designed conditions of exposure were varied for each performance level, based on the 4 environmental exposure classes (EEC) of ABNT NBR 6118 [3] and ABNT NBR 12655 [11], totalizing 12 situations. It was noted that the increased performance level increases consumption of materials, and the designs made for EEC IV consumed 12.3% and 16.2% more steel and concrete at the intermediate and superior performance levels respectively, when compared to the minimum performance level.
DOI: 10.6084/m9.figshare.9900164
title: Effect of extrusion cooking on physicochemical properties of tuna meat-based extrudates

description: Abstract Effect of extrusion cooking using different corn starch contents on the physicochemical properties (expansion ratio, bulk density, color, hardness, protein in vitro digestibility, crude protein content, thermal properties and microstructure) of tuna meat-based extrudates was investigated. The results showed that the increased corn starch content led to darker, greener, yellower and lower crude protein content of extrudates, but no significant difference was observed in expansion ratio, bulk density and hardness. The lowest protein in vitro digestibility of 82.83±0.39% appeared when the corn starch content was 20 wt%. The results of DSC revealed that tuna meat with corn starch content of 30 wt% and 20 wt% had the highest and lowest denaturation temperature of 99.4oC and 81.9 oC, respectively. The results of SEM indicated that the extrudate with 30 wt% corn starch content possessed the more integrated and distinct muscle fibers. Besides, the acceptability of the extrudate with 30 wt% corn starch content was significant better than others (p˂0.05). These results revealed that the tuna meat-based extrudates using 30 wt% of corn starch exhibited desirable physicochemical properties.
DOI: 10.6084/m9.figshare.9900173.v1
title: Pressures from the context and institutional capacity building to develop industrial symbiosis networks

description: Abstract This research analyzes the importance of the institutional and economic context and the institutional capacity building to develop an industrial symbiosis networks through the “Programa Mineiro de Simbiose Industrial” (PMSI). The research is qualitative, exploratory and descriptive, using content analysis techniques. Interviews were conducted with managers and government actors with active PMSI participation. The institutional and economic contexts and the current knowledge, mobilization and relational capacities were identified. The results indicate that the industrial symbiosis network is not dense and there are few waste exchanges among companies. There is an effort among actors who participate in the PMSI to build knowledge, mobilization and relationship capacities. However, the institutional context is unfavorable to the development of industrial symbiosis. This study article reinforces the need to invest in eco-innovative solutions and institutional environment improvements to develop efficient natural resources and waste management, and thus allow the development of eco-industrial parks.
DOI: 10.6084/m9.figshare.9900158
title: Preparation of beta-carotene nanoemulsion and evaluation of stability at a long storage period

description: Abstract Carotenoids have a low solubility in water, and therefore their incorporation in foods is impaired. The nanoemulsions are able to protect these compounds and enhance bioavailability. The objective of this study was to develop nanoemulsions with added beta-carotene, evaluating the influence of process variables and the stability at a long storage period. To assess the effects of these variables a Box-Behnken design was performed. The best condition to form a stable emulsion was 7% (w.w-1) of surfactant and 40 °C. All formulations subjected to a thermal stress test remained stable after the test. The use of a higher concentration of soy lecithin (7%, w.w-1) in the development of emulsions conferred greater stability after a freeze-defrost cycle. Furthermore, with this concentration of surfactant, and using a high-speed homogenizer under conditions of 10,000 rpm, 30 °C, and 20 min of shaking time, it was possible to develop stable nanoemulsion with an average diameter of 429 nm. Moreover, the zeta potential indicated system stability. Thus, it was possible to obtain stable nanoemulsion without the use of subsequent equipment, which makes the process less expensive.
DOI: 10.6084/m9.figshare.9900164.v1
title: Effect of extrusion cooking on physicochemical properties of tuna meat-based extrudates

description: Abstract Effect of extrusion cooking using different corn starch contents on the physicochemical properties (expansion ratio, bulk density, color, hardness, protein in vitro digestibility, crude protein content, thermal properties and microstructure) of tuna meat-based extrudates was investigated. The results showed that the increased corn starch content led to darker, greener, yellower and lower crude protein content of extrudates, but no significant difference was observed in expansion ratio, bulk density and hardness. The lowest protein in vitro digestibility of 82.83±0.39% appeared when the corn starch content was 20 wt%. The results of DSC revealed that tuna meat with corn starch content of 30 wt% and 20 wt% had the highest and lowest denaturation temperature of 99.4oC and 81.9 oC, respectively. The results of SEM indicated that the extrudate with 30 wt% corn starch content possessed the more integrated and distinct muscle fibers. Besides, the acceptability of the extrudate with 30 wt% corn starch content was significant better than others (p˂0.05). These results revealed that the tuna meat-based extrudates using 30 wt% of corn starch exhibited desirable physicochemical properties.