cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7898720
title: Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma

description: Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wound healing assay were performed to determine cell proliferation, invasion and migration. Flow cytometry and TUNEL assay were used to measure cell apoptosis. Quantitative real-time PCR and western blotting assays were used to determine mRNA and protein expression levels. Xenograft experiment was performed to determine the in vivo anti-tumor effect of polydatin. Immunostaining was performed to analyze the expression of caspase-3 and Ki-67. Our results showed that polydatin inhibited cell proliferation in a concentration-dependent and time-dependent manner in the HCC cell lines. Polydatin also induced cell apoptosis in a concentration-dependent manner possibly via increasing the caspase-3 activity, and up-regulating the protein expression of caspase-3, caspase-9, Bax, and down-regulating the protein expression of Bcl-2. In addition, polydatin treatment had an inhibitory effect on cell proliferation, invasion and migration in HCC cell lines. Polydatin treatment also suppressed the Wnt/beta-catenin signaling activities in HCC cells. Polydatin treatment significantly reduced tumor growth in nude mice inoculated with HepG2 cells, suppressed the expression of Ki-67, and increased caspase-3 expression and TUNEL activity. Our data indicated the important role of polydatin for the suppression of HCC progression.
DOI: 10.6084/m9.figshare.13141688
title: Additional file 1 of Clinical features and efficacy of antiviral drug, Arbidol in 220 nonemergency COVID‐19 patients from East-West-Lake Shelter Hospital in Wuhan: a retrospective case series

description: Additional file 1: Table S1. Basic clinical and epidemic features based on gender. a Including dry cough, expectoration, chest tightness and shortness of breath, fatigue, muscle soreness, stuffy running nose, headache, pharyngalgia, thoracalgia, dyspnea, phlegm blood, chills and poor appetite.
DOI: 10.6084/m9.figshare.13141688.v1
title: Additional file 1 of Clinical features and efficacy of antiviral drug, Arbidol in 220 nonemergency COVID‐19 patients from East-West-Lake Shelter Hospital in Wuhan: a retrospective case series

description: Additional file 1: Table S1. Basic clinical and epidemic features based on gender. a Including dry cough, expectoration, chest tightness and shortness of breath, fatigue, muscle soreness, stuffy running nose, headache, pharyngalgia, thoracalgia, dyspnea, phlegm blood, chills and poor appetite.
DOI: 10.6084/m9.figshare.13141787
title: Additional file 1 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 1. In Additional file 1 (Table S1), we show the expression quantitative trait methylation (eQTM) results per gene expression probe.
DOI: 10.6084/m9.figshare.13141787.v1
title: Additional file 1 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 1. In Additional file 1 (Table S1), we show the expression quantitative trait methylation (eQTM) results per gene expression probe.
DOI: 10.6084/m9.figshare.13141790
title: Additional file 2 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 2. In Additional file 2, we provided the R code we used for obtaining the residuals of the smoking-related CpGs and genes. Also, we provided the R code used to test the eQTM associations.
DOI: 10.6084/m9.figshare.13141790.v1
title: Additional file 2 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 2. In Additional file 2, we provided the R code we used for obtaining the residuals of the smoking-related CpGs and genes. Also, we provided the R code used to test the eQTM associations.
DOI: 10.6084/m9.figshare.13141793
title: Additional file 3 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 3. In Additional file 3, we included supplementary Tables S2-S9. In Tables S2-S5, we show the results for the associations between cardio-metabolic traits with DNA methylation model 1 (Table S2) and model 2 (Table S3), and gene expression model 1 (Table S4) and model 2 (Table S5). In Table S6, we show all the three-way associations obtained in the discovery. In Table S7, we show the mediation results for all the three-way associations obtained in the discovery, and the results obtained in the replication. In Table S8, we show the CpGs, and in Table S9, we show the gene expression probes that were included in the current study as markers of interest.
DOI: 10.6084/m9.figshare.13141793.v1
title: Additional file 3 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 3. In Additional file 3, we included supplementary Tables S2-S9. In Tables S2-S5, we show the results for the associations between cardio-metabolic traits with DNA methylation model 1 (Table S2) and model 2 (Table S3), and gene expression model 1 (Table S4) and model 2 (Table S5). In Table S6, we show all the three-way associations obtained in the discovery. In Table S7, we show the mediation results for all the three-way associations obtained in the discovery, and the results obtained in the replication. In Table S8, we show the CpGs, and in Table S9, we show the gene expression probes that were included in the current study as markers of interest.
DOI: 10.6084/m9.figshare.13141796
title: Additional file 4 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 4. In Additional file 4, we provided the R code we used for testing the association between the smoking-related CpGs and the cardio-metabolic traits.
DOI: 10.6084/m9.figshare.13141796.v1
title: Additional file 4 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 4. In Additional file 4, we provided the R code we used for testing the association between the smoking-related CpGs and the cardio-metabolic traits.
DOI: 10.6084/m9.figshare.13141799
title: Additional file 5 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 5. In Additional file 5, we provided the R code we used for testing the association between the smoking-related gene expression probes and the cardio-metabolic traits.
DOI: 10.6084/m9.figshare.13141799.v1
title: Additional file 5 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 5. In Additional file 5, we provided the R code we used for testing the association between the smoking-related gene expression probes and the cardio-metabolic traits.
DOI: 10.6084/m9.figshare.13141802
title: Additional file 6 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 6. In Additional file 6, we provided the R code we used for the mediation analysis.
DOI: 10.6084/m9.figshare.13141802.v1
title: Additional file 6 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 6. In Additional file 6, we provided the R code we used for the mediation analysis.
DOI: 10.6084/m9.figshare.13141805
title: Additional file 7 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 7. In Additional file 7, we provided the input file we used in the discovery phase for mediation analysis.
DOI: 10.6084/m9.figshare.13141805.v1
title: Additional file 7 of Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

description: Additional file 7. In Additional file 7, we provided the input file we used in the discovery phase for mediation analysis.
DOI: 10.6084/m9.figshare.6326066
title: Efficient 1,6-addition reactions of 3-substituted oxindoles: Access to isoxazole-fused 3,3′-disubstituted oxindole scaffolds and hexahydro-1<i>h</i>-pyrido[2,3-<i>b</i>]indol-2-one scaffolds

description: Developed herein is a new methodology for a hybrid of two pharmacophoric oxindole and isoxazole motifs to construct isoxazole-fused 3,3′-disubstituted oxindole scaffolds <i>via</i> an efficient 1,6-addition reaction of 3-substituted oxindoles to 3-methyl-4-nitro-5-alkenylisoxazoles, which might generate novel drug-like molecules for biological screenings. The method gives an easy access to a series of isoxazole-fused 3,3′-disubstituted oxindoles with 26 examples in high yields (up to 92% yield) and good diastereoselectivity (up to &gt;20:1), which makes possible the synthesis of libraries under similar circumstances. Subsequently, a sequential Michael addition/amidation/reductive cyclization process was designed for accessing this hexahydro-1<i>H</i>-pyrido[2,3-<i>b</i>]indol-2-one scaffold, which is a key structural skeleton found in a large number of biologically active natural products and pharmaceutical compounds. Hexahydro-1<i>H</i>-pyrido[2,3-<i>b</i>]indol-2-one scaffold <b>7cg</b> could be obtained in 42.5% overall yield after 4 steps.
DOI: 10.6084/m9.figshare.6326066.v1
title: Efficient 1,6-addition reactions of 3-substituted oxindoles: Access to isoxazole-fused 3,3′-disubstituted oxindole scaffolds and hexahydro-1<i>h</i>-pyrido[2,3-<i>b</i>]indol-2-one scaffolds

description: Developed herein is a new methodology for a hybrid of two pharmacophoric oxindole and isoxazole motifs to construct isoxazole-fused 3,3′-disubstituted oxindole scaffolds <i>via</i> an efficient 1,6-addition reaction of 3-substituted oxindoles to 3-methyl-4-nitro-5-alkenylisoxazoles, which might generate novel drug-like molecules for biological screenings. The method gives an easy access to a series of isoxazole-fused 3,3′-disubstituted oxindoles with 26 examples in high yields (up to 92% yield) and good diastereoselectivity (up to &gt;20:1), which makes possible the synthesis of libraries under similar circumstances. Subsequently, a sequential Michael addition/amidation/reductive cyclization process was designed for accessing this hexahydro-1<i>H</i>-pyrido[2,3-<i>b</i>]indol-2-one scaffold, which is a key structural skeleton found in a large number of biologically active natural products and pharmaceutical compounds. Hexahydro-1<i>H</i>-pyrido[2,3-<i>b</i>]indol-2-one scaffold <b>7cg</b> could be obtained in 42.5% overall yield after 4 steps.
DOI: 10.6084/m9.figshare.13141838
title: Additional file 3 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 3: Table S1. Statistics of transcriptome data generated by Iso-seq.
DOI: 10.6084/m9.figshare.13141841
title: Additional file 4 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 4: Table S2. Identification of AS events from all transcriptome.
DOI: 10.6084/m9.figshare.13141844.v1
title: Additional file 5 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 5: Table S3. GO enrichment analysis of isoforms in cluster 1 and 2.
DOI: 10.6084/m9.figshare.13141847
title: Additional file 6 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 6: Table S4. GO enrichment analysis of specific isoforms at each stage.
DOI: 10.6084/m9.figshare.13141850
title: Additional file 7 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 7: Table S5. Specific transcripts in each peg tissue.
DOI: 10.6084/m9.figshare.13141838.v1
title: Additional file 3 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 3: Table S1. Statistics of transcriptome data generated by Iso-seq.
DOI: 10.6084/m9.figshare.13141841.v1
title: Additional file 4 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 4: Table S2. Identification of AS events from all transcriptome.
DOI: 10.6084/m9.figshare.13141844
title: Additional file 5 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 5: Table S3. GO enrichment analysis of isoforms in cluster 1 and 2.
DOI: 10.6084/m9.figshare.13141847.v1
title: Additional file 6 of Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development

description: Additional file 6: Table S4. GO enrichment analysis of specific isoforms at each stage.
DOI: 10.5281/zenodo.5122842
title: Crop mapping data

description: Images of different crops in the study area
DOI: 10.5281/zenodo.5122841
title: Crop mapping data

description: Images of different crops in the study area
DOI: 10.17632/btswpd7pvm.2
title: Data for ACP

description: The datasets contains the PMF model, PARAFAC model, and the data of light absorption paramater.
DOI: 10.17632/sspngbxbcz.1
title: Finnie, Komoroski, Bear (2021). The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity. Current Biology. https://doi.org/10.1016/j.cub.2021.06.079. Accompanying dataset
DOI: 10.17632/sspngbxbcz.2
title: Finnie, Komoroski, Bear (2021). The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity. Current Biology. https://doi.org/10.1016/j.cub.2021.06.079. Accompanying dataset
DOI: 10.17632/hcykmcj2x9.1
title: Data for Sinuous bar fingers of digitate shallow-water deltas: Insights into their formative processes and deposits from integrating morphological and sedimentological studies with mathematical modelling

description: Mat files include the time-varied depth-averaged velocities and water depths of four simulations (S1-S4). They are Matlab data and can be played by code "figureplaynew.m". Simulation S1.zip is the Delft3D domain of simulation S1.
DOI: 10.17632/pbnc4zhcwd.1
title: Transcription-mediated supercoiling regulates genome folding and loop formation - Neguembor et al
DOI: 10.17632/hvgctxwsdw.1
title: Root system of Jatropha curcas

description: Jatropha curcas (L.) has been studied as a reinforcing element against slope erosion to protect from the impact of raindrops provided by the plant shoot and the anchorage of the root system. Thus, the objective of this study was to evaluate the behavior of the root system of hybrids of Jatropha curcas (L.) regarding to the physical-mechanical reinforcing capacity of the soil and its potential of contribution in the stabilization of slopes on erosion processes. The monolith method was used to measure root density, root length density, root area rate, root resistance to rupture and the root cohesion. Root length using the cylinder method was also verified. The results were submitted to variance analysis, and then the polynomial regression analysis was conducted. Root volume, root density, root average density, and root distribution decrease with the soil depth, increasing with a strong negative correlation between indexes and soil depth. Jatropha shoot dry mass can provide to the soil and strong vegetation cover that improves the soil surface protection related to the erosion processes. J. curcas roots resist breakage due to their pivoting system that provides better anchorage in deeper soil layers. In contrast, while shallow roots provide a surface anchoring system that aids in soil stabilization.
DOI: 10.6084/m9.figshare.15036312
title: SEAR scenarios

description: 220 SEAR scenarios
DOI: 10.17632/mvtd4fjjvj.2
title: Dataset and algorithms for identifying stagnation zones and reverse flow caused by river-aquifer interaction

description: This dataset is part of the Supplementary Material of the research: Identifying stagnation zones and reverse flow caused by river-aquifer interaction: An approach based on polynomial chaos expansions. The code infrastructure, the programming scripts, the simulation results, and the dataset files are stored in this online repository. The results of the research and the simulation can be reproduced by following the instructions in the "readme.md" file.
DOI: 10.5281/zenodo.5122865
title: trend-db - Snapshot of the data folder

description: trend-db - Snapshot of the data folder This archive is to be downloaded in the master folder of the trend-db software. By unpacking this archive, the data/ folder is populated with the required objects to correctly run the trend-db database The work on trend-db is described in our manuscript available at https://academic.oup.com/nar/article/49/D1/D243/5911742 doi: 10.1093/nar/gkaa722
DOI: 10.5281/zenodo.5122864
title: trend-db - Snapshot of the data folder

description: trend-db - Snapshot of the data folder This archive is to be downloaded in the master folder of the trend-db software. By unpacking this archive, the data/ folder is populated with the required objects to correctly run the trend-db database The work on trend-db is described in our manuscript available at https://academic.oup.com/nar/article/49/D1/D243/5911742 doi: 10.1093/nar/gkaa722
DOI: 10.17632/h79h6t77tj.1
title: External Database 3

description: External Database 3 for Brown et al., 2021
DOI: 10.17632/s99c7tmmmg.1
title: The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris

description: Supplementary material for publication "The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris ".
DOI: 10.17632/96h5d66dby.1
title: LDHU3_04.0390

description: mitochondrial exoribonuclease DSS-1 | KDSS1 Leishmania donovani (HU3 strain)
DOI: 10.17632/djj5s5nyxc.1
title: Supplemental Materials for Stein Gold et al. Efficacy and Safety of Apremilast in Patients with Mild to Moderate Plaque Psoriasis: Results of a Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial. J Am Acad Dermatol. 2021.

description: Mendeley Supplemental Figures and Table for Stein Gold et al. Efficacy and Safety of Apremilast in Patients with Mild to Moderate Plaque Psoriasis: Results of a Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial. J Am Acad Dermatol. 2021.
DOI: 10.17632/hbgwpfpzz4.1
title: LDHU3_04.0430

description: RESC14 Leishmania donovani (HU3 strain)
DOI: 10.17632/gby3nbmp8m.1
title: LDHU3_04.0330

description: mitoribosomal protein uL29m Leishmania donovani (HU3 strain)
DOI: 10.17632/f6r4srmdgz.1
title: LDHU3_04.0600

description: adenylosuccinate lyase Leishmania donovani (HU3 strain)
DOI: 10.17632/w8vgz23444.1
title: Data for: Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach

description: The Cytoscape network files used in our research work.
DOI: 10.17632/9m45mvbzv8.1
title: LDHU3_04.0300

description: GRAM domain containing protein Leishmania donovani (HU3 strain)
DOI: 10.17632/t68kyvbb48.1
title: Querfeld_ 202 Research Letter_Supplementary_JAAD

description: Supplementary information relating to manuscript titled 'Use of chlormethine 0.04% gel for mycosis fungoides after treatment with topical chlormethine 0.02% gel: a phase 2 extension study' publishsed in JAAD
DOI: 10.17632/n5hrbw7m32.1
title: LDHU3_04.0280

description: hypothetical protein - conserved Leishmania donovani (HU3 strain)
DOI: 10.17632/n8z3g6dcks.1
title: LDHU3_04.0350

description: alcohol dehydrogenase-like protein Leishmania donovani (HU3 strain)
DOI: 10.17632/2pdc6m9gn4.3
title: Data : the effects of cellulase treatments on pink guava by-products

description: The solid waste generated from pink guava (Psidium guajava L.) puree processing is fiber-rich and it has limited nutrient digestibility and bioavailability. We investigated the effect of cellulase on structure-fermentability of the by-products, namely Refiner, Siever and Decanter. We removed most of the soluble sugar from the by-products, then estimated the hydrolysis of the different guava by-products by comparing the reducing sugar content in the effluent after treatment (1). We tested the sugar content in the distilled water used to wash the guava by-products by using the 3,5 dinitrosalicylic acid assay (2). We applied cellulase treatment on the by-products (Refiner, Siever and Decanter) and separated them into ethanolic extract (EEC) and alcohol insoluble fiber (AIF). We determined total soluble carbohydrate content and the molecular weight distribution of the soluble carbohydrates and prebiotic activity of the EEC. We also quantified the bile acid-binding capacity, and structural properties of the AIF. Cellulase treatment has led to the dissolution of the insoluble fiber (3). Siever and decanter showed a increase in total soluble carbohydrate content after cellulase treatment (4). Molecular weight distribution profile of soluble carbohydrates in the EEC showed a shift from high to low (5). The EEC of all cellulase-treated guava by-products exhibited higher prebiotic activity scores compared to those of the untreated samples (6). Cellulase treatments also affected crystallinity index as observed through X-ray crystallography analysis (7). Changes in the structure lattice were manifested as an improved capacity in binding bile acids (8). 1. Hydrolysis extent of guava by-products 2. Reducing sugar content in 1st washing and 2nd washing of the guava by-products. 3. Alcohol Insoluble Fiber (AIF) Yield 4. Total soluble carbohydrate content in the ethanolic extract (EEC) 5. Molecular weight distribution of soluble carbohydrates in different guava by-products. 6. Prebiotic activity score (raw data) 7. X-ray diffraction data of untreated and cellulase-treated guava by-products. 8. Bile-acid binding capacity
DOI: 10.17632/ksszgry524.2
title: Industrial Expectation from MBA Students: Some reflection with reference to RTM Nagpur University, Nagpur

description: Management education in RTM, Nagpur University approximately 20 years old. It is precisely designed to develop the business decision-making skills of students. Business Management education plays an important role in developing managerial as well employability skills. The courses in many MBA Institutes across country are exam driven, which aims at creating a plain student rather than its objective of imparting knowledge. The corporate require a student who can be readily absorbed into the company, without the company having the need to spend much on training on how the corporate works and the job assigned to the student after hiring. The business management education should also aim at framing the student’s attitude, which should be challenge driven and adaptable. The paper explores the gap between industry expectations from management students from RTM Nagpur University. Also the outcome of present research paper is expected to benefit academicians like, teachers and students as it will help them in understanding the creativity in Management curriculum in the context of the contemporary local and global economic scenario. Keywords: Education, Management, skills, development, employability etc.