cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.5qgfaf
title: Occurrence Download

description: A dataset containing 519205 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Pluchea dentex, Euphrasia trifida, Pandanus oblatus, Moenchia graeca, Nicotiana solanifolia, Lagenophora platysperma, Phacelia minutiflora, Phacelia secunda, Delosperma calitzdorpense, Solidago velutina, Achillea falcata, Euphrasia flava, Rudbeckia hirta, Spilanthes leiocarpa, Caustis pentandra, Colchicum troodi, Plectranthus strigosus, Phacelia barnebyana, Delosperma sawdahense, Guichenotia asteriskos, Diphysa echinata, Datura wrightii, Euphrasia marchesettii, Phymaspermum aciculare, Oxytropis helvetica, Nicotiana attenuata, Euphrasia achibuenoensis, Delosperma grantiae, Achillea cretica, Pluchea chingoyo, Pandanus rheophilus, Watsonia hysterantha, Oxytropis kotschyana, Achillea aspleniifolia, Achillea kirschneri, Nicotiana bilybara, Phacelia davidsonii, Polypsecadium zoellneri, Crinodendron hookerianum, Lagenophora brachyglossa, Euphrasia subexserta, Achillea ptarmica, Achillea lingulata, Achillea nana, Spilanthes costata, Brassavola appendiculata, Colchicum antilibanoticum, Colchicum davisii, Colchicum doerfleri, Euphrasia tricuspidata, Watsonia inclinata, Peucedanum ruthenicum, Cystopteris tasmanica, Morinda citrifolia, Cistanthe neonominata, Epipactis veratrifolia, Orchis serraniana, Hereroa incurva, Hereroa joubertii, Schotia brachypetala, Indigofera georgei, Westringia cephalantha, Westringia lurida, Pauridia longituba, Vallisneria spiralis, Distichlis humilis, Synaphea trinacriformis, Aconitum columbianum, Hymenocallis araniflora, Armeria leucocephala, Nemacladus sigmoideus, Cordylanthus kingii, Indigofera charlieriana, Indigofera gifbergensis, Indigofera mollis, Pavetta kimberleyana, Orchis ehdenica, Epipactis gigantea, Russelia grandidentata, Scrophularia capillaris, Scrophularia gracilis, Scrophularia glabrata, Indigofera amoena, Indigofera obcordata, Orchis caesii, Synaphea bifurcata, Epipactis garganica, Lindsaea ensifolia, Indigofera, Hereroa stenophylla, Prunus zingii, Scrophularia atrata, Glaucium grandiflorum, Crucianella chlorostachys, Crucianella imbricata, Westringia longifolia, Vallisneria nana, Vallisneria triptera, Melica imperfecta, Schinus montana)",
 "Year is greater than or equal to 1950"
 ]
}

 The dataset includes 519205 records from 2003 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050243-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/independent-c69-33300
title: Claims (GX 13106 - GX 13463), 1987

description: Collection of claims filed against the LAPD with regards ranging from wrongful death to violation of civil rights, etc., 1987. PART OF A SERIES: The series includes materials related to the work product of Price Waterhouse, whose staff investigated citizen complaints and civil litigation claims involving the LAPD. Included are claims reports, claims analyses, card files, and arbitration reports; summaries of 83 selected civil litigation cases; materials from the personnel files of LAPD officers named in these cases, as well as documents listing their subsequent penalties; and statistics that break complaints down according to a variety of criteria, including race, gender, and police division.
DOI: 10.15468/dl.zcrapz
title: Occurrence Download

description: A dataset containing 11 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cypripedium subtropicum S.C.Chen & K.Y.Lang"
 ]
}

 The dataset includes 11 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002853-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mhjwta
title: Occurrence Download

description: A dataset containing 6971 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Observation, Machine Observation, Material sample, Material citation, Specimen, Fossil, Living Specimen, Occurrence evidence)",
 "OccurrenceStatus is Present",
 "TaxonKey is Malacoptila striata (von Spix, 1824)"
 ]
}

 The dataset includes 6971 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005321-230918134249559/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jc2adh
title: Occurrence Download

description: A dataset containing 5783 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is FloVegSI-FAV - Faunistical database of ZRC SAZU"
 ]
}

 The dataset includes 5783 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002380-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k42beq
title: Occurrence Download

description: A dataset containing 609649 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Spain)",
 "BasisOfRecord is one of (Observation, Human Observation, Material sample, Literature Occurrence, Specimen, Unknown evidence, Machine Observation)",
 "Year is greater than or equal to 2023",
 "Year is less than or equal to 2023",
 "HasCoordinate is true"
 ]
}

 The dataset includes 609649 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050943-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hhbacy
title: Occurrence Download

description: A dataset containing 45247 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Myriophyllum spicatum L.",
 "HasCoordinate is true",
 "Continent is Europe",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2000",
 "CoordinateUncertaintyInMeters is less than 10000"
 ]
}

 The dataset includes 45247 records from 335 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0026330-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/independent-c69-33340
title: Claims (GX 13106 - GX 13463), 1987

description: Collection of claims filed against the LAPD with regards ranging from wrongful death to violation of civil rights, etc., 1987. PART OF A SERIES: The series includes materials related to the work product of Price Waterhouse, whose staff investigated citizen complaints and civil litigation claims involving the LAPD. Included are claims reports, claims analyses, card files, and arbitration reports; summaries of 83 selected civil litigation cases; materials from the personnel files of LAPD officers named in these cases, as well as documents listing their subsequent penalties; and statistics that break complaints down according to a variety of criteria, including race, gender, and police division.
DOI: 10.15468/dl.8dzwed
title: Occurrence Download

description: A dataset containing 455 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Chenopodium graveolens Willd."
 ]
}

 The dataset includes 455 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006146-240202131308920/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.aznq7e
title: Occurrence Download

description: A dataset listing the 239 species recorded in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-136.40635 20.72405,-49.87764 20.72405,-49.87764 55.32072,-136.40635 55.32072,-136.40635 20.72405))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Hypericum L."
 ]
}

 The dataset's 239 records were derived from 271 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0050938-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4mefks
title: Occurrence Download

description: A dataset listing the 1187004 species recorded in GBIF matching the query:
{
 "HostingOrganizationKey" : [
 "is fbca90e3-8aed-48b1-84e3-369afbd000ce"
 ]
}

 The dataset's 1187004 records were derived from 2538 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001361-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yqgkmr
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cottus jaok Cuvier, 1829",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005986-241126133413365/datasets/export for details.
DOI: 10.15468/dl.feefdh
title: Occurrence Download

description: A dataset containing 5387 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Paguma larvata (C.E.H.Smith, 1827))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 5387 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005987-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15151/esrf-es-1897083444
title: Molecular machines in energy transduction, cellular signaling and defense processes

description: This BAG is composed of 6 working groups from 3 locations (university of Cologne, Bochum, Düsseldorf), the projects for this proposal are rather heterogeneous. Nonetheless, we are focusing on 6 main topics:
1.) proteins involved in transport processes, transporters or channels, either embedded in the membrane or acting in the cytosol (e.g. ABC transporters, fusion proteins, regulators)
2.) proteins involved in the immune system, pathogen invasion or defense/resistance processes (dehydratases, toxins, binding proteins)
3.) proteins involved or associated with diseases like cancer or developmental disorders (e.g. kinase, toxins)
4.) enzymes of putative industrial use to encounter increasing environmental pollution (e.g. transaminases, estereases)
5.) proteins involved in light harvesting, photosynthesis (C3/C4 pathways) and chromophore binding (e.g. synthases, photosensor domains)
6.) signaling or transport processes (e.g. ethylene, collagen) or fixation ([Fe-Fe]-hydrogenases)
DOI: 10.15468/dl.g9yggx
title: Occurrence Download

description: A dataset containing 147 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Inimicus japonicus (Cuvier, 1829)",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 147 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005988-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15151/esrf-es-1995797470
title: Growth of palladium-silver colloidal particles

description: The slow growth of palladium-silver Janus colloidal particles will be followed by time-resolved SAXS
DOI: 10.6084/m9.figshare.27308583
title: Evaluation of orphan maintained biological medicinal products in the European Union between 2018 to 2023: a regulatory perspective

description: Orphan medicinal products (OMPs) authorized by the European Union (EU) benefit from market exclusivity, fee waivers, and national incentives. Maintaining orphan status during a marketing authorization application requires meeting eligibility criteria, especially demonstrating significant benefit (SB), which is challenging. This study identifies key features linked to successful orphan status maintenance for biological OMPs approved in the EU between 2018 and 2023. Data from European public assessment reports and orphan maintenance assessment reports were analyzed. Among the 50 biological OMP maintained orphan designations, 68.0% had to demonstrate SB over existing treatments, with 91.2% leveraging the clinically relevant advantage area, utilizing better clinical efficacy (83.9%) and efficacy in subpopulations (38.7%) subdomains. However, 32.0% did not need to demonstrate SB due to a lack of alternative treatments, most of which were ultra-orphan drugs. Advanced therapy medicinal products and monoclonal antibodies were the most numerous OMP categories, whereas oncology and immunomodulation were the preferred therapeutic areas. The Orphan Regulation is essential in advancing treatments for rare diseases, fostering innovation while addressing unmet medical needs. Nonetheless, the insufficient return on investment criterion remains underused, whereas refining major contribution to patient care guidelines and incorporating real-world evidence may enhance regulatory evaluations.
DOI: 10.6084/m9.figshare.27308583.v2
title: Evaluation of orphan maintained biological medicinal products in the European Union between 2018 to 2023: a regulatory perspective

description: Orphan medicinal products (OMPs) authorized by the European Union (EU) benefit from market exclusivity, fee waivers, and national incentives. Maintaining orphan status during a marketing authorization application requires meeting eligibility criteria, especially demonstrating significant benefit (SB), which is challenging. This study identifies key features linked to successful orphan status maintenance for biological OMPs approved in the EU between 2018 and 2023. Data from European public assessment reports and orphan maintenance assessment reports were analyzed. Among the 50 biological OMP maintained orphan designations, 68.0% had to demonstrate SB over existing treatments, with 91.2% leveraging the clinically relevant advantage area, utilizing better clinical efficacy (83.9%) and efficacy in subpopulations (38.7%) subdomains. However, 32.0% did not need to demonstrate SB due to a lack of alternative treatments, most of which were ultra-orphan drugs. Advanced therapy medicinal products and monoclonal antibodies were the most numerous OMP categories, whereas oncology and immunomodulation were the preferred therapeutic areas. The Orphan Regulation is essential in advancing treatments for rare diseases, fostering innovation while addressing unmet medical needs. Nonetheless, the insufficient return on investment criterion remains underused, whereas refining major contribution to patient care guidelines and incorporating real-world evidence may enhance regulatory evaluations.
DOI: 10.15151/esrf-es-1893932539
title: IBS BAG

description: The IBS BAG includes in this proposal IBS teams and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2498 proposal and can be grouped into different topics as follows: host-pathogen interaction, new therapy targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR), together with other biophysical and biochemical studies, and very recently the use of AI, with the aim to fully understand the complexity of the biological macromolecular systems under study.
DOI: 10.6084/m9.figshare.27308583.v1
title: Evaluation of orphan maintained biological medicinal products in the European Union between 2018 to 2023: a regulatory perspective

description: Orphan medicinal products (OMPs) authorized in the European Union (EU) benefit from market exclusivity, fee waivers, and national incentives. Maintaining orphan status during the marketing authorization application (MAA) requires meeting eligibility criteria, especially demonstrating significant benefit (SB), which is challenging. This study identifies key features linked to successful orphan status maintenance for biological OMPs approved in the EU between 2018 and 2023. Data from European public assessment reports and orphan maintenance assessment reports were analyzed. Among the 50 biological OMPs granted orphan designation, 68.0% had to demonstrate SB over existing treatments, with 91.2% leveraging the clinically relevant advantage area, utilizing better clinical efficacy (83.8%) and subpopulation (38.7%) sub-domains. However, 32% did not need to demonstrate SB due to a lack of alternative treatments, most of which were ultra-orphan drugs. Advanced therapy medicinal products and monoclonal antibodies were the most numerous OMP categories, whereas oncology and immunomodulation were the preferred therapeutic areas. The Orphan Regulation plays a critical role in advancing treatments for rare diseases, fostering innovation while addressing unmet medical needs. Nonetheless, the insufficient return on investment criterion remains underused, whereas refining major contribution to patient care guidelines and incorporating real-world evidence may enhance regulatory evaluations.
DOI: 10.15151/esrf-es-1896698635
title: ITABAG: 3D structures of macromolecules related to human health

description: The ITABAG includes structural biologists from Universities, the National Research Council and Hospital research centres in Italy. The laboratories take advantage of single crystal and small angle X-ray diffraction methods to study the structure-function relationships in various macromolecules. A unifying factor for the clear majority of the macromolecules under study is their relationship to human health, either directly, being human proteins involved in some disease, or indirectly, as proteins expressed by human pathogens and validated as potential pharmacological targets. Other projects investigate basic chemical processes, the study of plant viral proteins, or aim at characterising macromolecules with potential biotechnological applications including drug delivery.
DOI: 10.15151/esrf-es-1899398629
title: Belgium BAG

description: The Belgium BAG includes groups situated at four Flemish universities: Antwerpen, Brussels, Ghent and Leuven. The proposed projects are highly diverse, including viral, prokaryotic and eukaryotic proteins with a strong focus on targets and processes of biomedical relevance. Many projects deal with membrane proteins, cell surface receptors and protein-protein complexes. Central to the research in the BAG associated groups is the employment of integrative methods in structural biology combining X-ray crystallography, SAXS, and electron microscopy. Many crystals in the various proposed projects are small in size and radiation sensitive, requiring the use of the high brilliance MX beam lines, preferably with micro-focused X-rays.
DOI: 10.15151/esrf-es-1925858421
title: Bridging the gap between cellular and whole body imaging using Hierarchical Phase-Contrast Tomography: HiP-CT

description: Humans and other large organisms are three-dimensional multiscale biological systems where large scale function and structure are dependent on the macrostructure’s interconnectivity down to the cellular and subcellular level. Using the exceptional coherence provided by the ESRF-EBS, we have demonstrated that propagation-based phase-contrast can effectively decouple resolution from specimen size in soft tissue, obtaining 1.4 micron voxel resolution in 150 mm diameter human organs. Through this Long Term Proposal (LTP) we will develop the techniques required to image whole human and animal bodies ex vivo at 25 micron resolution, zooming to sub-micron voxels (0.7micron) locally, resolving sub-cellular structures through hard- and soft-tissue. Resolving how the micro (sub-cellular) interacts with the macro (whole organism) across length scales will provide all new insights into biological and biomedical function. This is true for both healthy and pathological system level behaviour.
DOI: 10.15151/esrf-es-1931741653
title: An Investigation of morphological changes due to etching Ti porous transport layer via X-ray tomography for electrolyzer applications

description: Anodic porous transport layer (PTL) is a critical component for water/gas transportation to/from the anode catalyst layer and an important interface for electron/proton transfer in a proton exchange membrane electrolyzer cell. The common material used for PTL structure is Ti, which is highly prone to passivation in long-term application and can be degraded faster if it is not protected with a Pt coating. In order to deposit PTL with Pt, an etching procedure is required to remove formed TiO2 layer, resulting in huge morphological changes in this layer. The proposed study aims to investigate the morphological changes (porosity and PTL/catalyst interface) due to various etching conditions using X-ray tomography and correlates its influences with the electrolyzer performance.