cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7157360
title: Regorafenib monotherapy as second-line treatment of patients with RAS-mutant advanced colorectal cancer (STREAM): an academic, multicenter, single-arm, two-stage, phase 2 study

description: <strong>Background</strong> Maintaining angiogenesis inhibition and switching the chemotherapy backbone represent the current second-line therapy in patients with <em>RAS</em> mutant metastatic colorectal cancer (mCRC). Regorafenib, an oral multikinase inhibitor, prolonged overall survival (OS) in chemorefractory setting. <strong>Methods</strong> STREAM was an academic, multicenter, single-arm phase 2 trial, evaluating the activity of regorafenib in <em>RAS</em> mutant mCRC, in terms of the rate of patients who were progression-free after 6months from study entry (6mo-PF). Patients were pretreated with fluoropyrimidine, oxaliplatin and bevacizumab. According to Simon’s two-stage design, ≥ 18 patients 6mo-PF were needed in the overall population (N=46). Secondary endpoints were safety, objective response rate (ORR), progression-free survival (PFS) and OS. Early metabolic response by [18F]-FDG PET/CT scan was an exploratory endpoint. EudraCT Number:2015-001105-13 <strong>Results</strong> The number of patients 6mo-PF was 8/22 at the first stage and 14/46 in the overall population. ORR was 10.9%, Disease Control Rate 54.6%, median (m)PFS 3.6 months (mo) (95%CI 1.9-6.7), mOS 18.9 mo (95%CI 10.3-35.3), mPFS2 (from study entry to subsequent-line progression) was 13.3mo (95%CI=8.4-19.7). Long responders patients (&gt;6mo-PF) significantly more often had a single metastatic site and lung-limited disease. No unexpected toxicity was reported. Grade≥3 events occurred in 39.1% patients, mostly hand-foot syndrome (13%), fatigue and hyperbilirubinemia (6.5%). Baseline metabolic assessment was associated with OS in multivariate analysis, while early metabolic response was not associated with clinical outcomes. <strong>Conclusion</strong> The study did not meet its primary endpoint. However, regorafenib was well tolerated and did not preclude subsequent treatments. Patients with good prognostic features (single metastatic site and lung-limited disease) reported clinical benefit with regorafenib. The exploratory metabolic analysis suggests that baseline [18F]-FDG PET/CT might be useful to select patients with favorable outcome. A chemotherapy-free interval with regorafenib might be worth of further studies as second-line treatment in selected patients with RAS mutant mCRC.
DOI: 10.5281/zenodo.7157359
title: Regorafenib monotherapy as second-line treatment of patients with RAS-mutant advanced colorectal cancer (STREAM): an academic, multicenter, single-arm, two-stage, phase 2 study

description: <strong>Background</strong> Maintaining angiogenesis inhibition and switching the chemotherapy backbone represent the current second-line therapy in patients with <em>RAS</em> mutant metastatic colorectal cancer (mCRC). Regorafenib, an oral multikinase inhibitor, prolonged overall survival (OS) in chemorefractory setting. <strong>Methods</strong> STREAM was an academic, multicenter, single-arm phase 2 trial, evaluating the activity of regorafenib in <em>RAS</em> mutant mCRC, in terms of the rate of patients who were progression-free after 6months from study entry (6mo-PF). Patients were pretreated with fluoropyrimidine, oxaliplatin and bevacizumab. According to Simon’s two-stage design, ≥ 18 patients 6mo-PF were needed in the overall population (N=46). Secondary endpoints were safety, objective response rate (ORR), progression-free survival (PFS) and OS. Early metabolic response by [18F]-FDG PET/CT scan was an exploratory endpoint. EudraCT Number:2015-001105-13 <strong>Results</strong> The number of patients 6mo-PF was 8/22 at the first stage and 14/46 in the overall population. ORR was 10.9%, Disease Control Rate 54.6%, median (m)PFS 3.6 months (mo) (95%CI 1.9-6.7), mOS 18.9 mo (95%CI 10.3-35.3), mPFS2 (from study entry to subsequent-line progression) was 13.3mo (95%CI=8.4-19.7). Long responders patients (&gt;6mo-PF) significantly more often had a single metastatic site and lung-limited disease. No unexpected toxicity was reported. Grade≥3 events occurred in 39.1% patients, mostly hand-foot syndrome (13%), fatigue and hyperbilirubinemia (6.5%). Baseline metabolic assessment was associated with OS in multivariate analysis, while early metabolic response was not associated with clinical outcomes. <strong>Conclusion</strong> The study did not meet its primary endpoint. However, regorafenib was well tolerated and did not preclude subsequent treatments. Patients with good prognostic features (single metastatic site and lung-limited disease) reported clinical benefit with regorafenib. The exploratory metabolic analysis suggests that baseline [18F]-FDG PET/CT might be useful to select patients with favorable outcome. A chemotherapy-free interval with regorafenib might be worth of further studies as second-line treatment in selected patients with RAS mutant mCRC.
DOI: 10.6084/m9.figshare.21295218
title: Supplementary Material for: Response to Our Article Entitled “Zinc Supplementation and the Prevention and Treatment of Sepsis in Young Infants: A Systematic Review and Meta-Analysis”

description: no Abstract
DOI: 10.3886/e156321v2
title: Supplementary Data for "Childcare Subsidies and Child Skill Accumulation in One- and Two-Parent Families"

description: Supplementary data for online appendix of "Childcare Subsidies and Child Skill Accumulation in One- and Two-Parent Families"
DOI: 10.3886/e179681
title: Data and Code for JEEA: Alfaro, Cuñat, Fadinger, Liu, 2022 "The Real Exchange Rate, Innovation and Productivity"

description: We build a dynamic heterogeneous-firm model in which real depreciations raise export demand and the cost of importing intermediates, and also affect borrowing constraints and the profitability of engaging in R&D. A number of stylised facts on manufacturing firms for a large set of countries discipline our estimation: firms in emerging East Asia are very export oriented and rely little on imported intermediates, whereas the opposite holds for Latin America and Eastern Europe; firms from industrialized countries export as much as they import. Exporters experience an increase in cash ﬂow, R&D, and productivity growth in response to RER depreciations; importers experience the opposite outcomes. In counterfactual simulations of temporary RER movements, the effects on innovation and productivity growth are heterogeneous across regions, sizeable and persistent. In emerging Asia, real depreciations are associated with higher probabilities to engage in R&D, faster growth of average firm-level productivity and cash-ﬂow, and higher export entry rates; we find negative average effects on these outcomes for firms in other emerging economies, and no significant average effects for firms in industrialized economies.
DOI: 10.3886/e179681v1
title: Data and Code for JEEA: Alfaro, Cuñat, Fadinger, Liu, 2022 "The Real Exchange Rate, Innovation and Productivity"

description: We build a dynamic heterogeneous-firm model in which real depreciations raise export demand and the cost of importing intermediates, and also affect borrowing constraints and the profitability of engaging in R&D. A number of stylised facts on manufacturing firms for a large set of countries discipline our estimation: firms in emerging East Asia are very export oriented and rely little on imported intermediates, whereas the opposite holds for Latin America and Eastern Europe; firms from industrialized countries export as much as they import. Exporters experience an increase in cash ﬂow, R&D, and productivity growth in response to RER depreciations; importers experience the opposite outcomes. In counterfactual simulations of temporary RER movements, the effects on innovation and productivity growth are heterogeneous across regions, sizeable and persistent. In emerging Asia, real depreciations are associated with higher probabilities to engage in R&D, faster growth of average firm-level productivity and cash-ﬂow, and higher export entry rates; we find negative average effects on these outcomes for firms in other emerging economies, and no significant average effects for firms in industrialized economies.
DOI: 10.3886/e179681v2
title: Data and Code for JEEA: Alfaro, Cuñat, Fadinger, Liu, 2022 "The Real Exchange Rate, Innovation and Productivity"

description: We build a dynamic heterogeneous-firm model in which real depreciations raise export demand and the cost of importing intermediates, and also affect borrowing constraints and the profitability of engaging in R&D. A number of stylised facts on manufacturing firms for a large set of countries discipline our estimation: firms in emerging East Asia are very export oriented and rely little on imported intermediates, whereas the opposite holds for Latin America and Eastern Europe; firms from industrialized countries export as much as they import. Exporters experience an increase in cash ﬂow, R&D, and productivity growth in response to RER depreciations; importers experience the opposite outcomes. In counterfactual simulations of temporary RER movements, the effects on innovation and productivity growth are heterogeneous across regions, sizeable and persistent. In emerging Asia, real depreciations are associated with higher probabilities to engage in R&D, faster growth of average firm-level productivity and cash-ﬂow, and higher export entry rates; we find negative average effects on these outcomes for firms in other emerging economies, and no significant average effects for firms in industrialized economies.
DOI: 10.5281/zenodo.7124907
title: Datasets for article: "Growth, yield and fruit quality of tomato Solanum lycopersicum L grown in sewage-based compost in a semi-hydroponic cultivation system"

description: These are datasets for the article "Growth, yield and fruit quality of tomato Solanum lycopersicum L grown in sewage-based compost in a semi-hydroponic cultivation system "
DOI: 10.5281/zenodo.7124906
title: Datasets for article: "Growth, yield and fruit quality of tomato Solanum lycopersicum L grown in sewage-based compost in a semi-hydroponic cultivation system"

description: These are datasets for the article "Growth, yield and fruit quality of tomato Solanum lycopersicum L grown in sewage-based compost in a semi-hydroponic cultivation system "
DOI: 10.25625/9vekun/7yjf9d
title: 06 Model.R

description: :unav
DOI: 10.25625/9vekun/4tb0ob
title: 02 Data.R

description: :unav
DOI: 10.25625/9vekun/amwa96
title: 05 Bat activity calculation scale.R

description: :unav
DOI: 10.25625/9vekun/g8tzzc
title: 04 LiDAR data.R

description: :unav
DOI: 10.25625/9vekun/jec6hk
title: 01 Sound_exctinction_analysis.R

description: :unav
DOI: 10.25625/9vekun/utfqam
title: 03 Visualise data without outliner.R

description: :unav
DOI: 10.25625/9vekun/2drwyn
title: Landscape assessment - selected plots.tab

description: :unav
DOI: 10.25625/9vekun/csiffl
title: VIviane's tags.tab

description: :unav
DOI: 10.25625/9vekun/yr3sz7
title: activity.csv

description: :unav
DOI: 10.25625/9vekun/k6stcj
title: landuse_LA.tab

description: :unav
DOI: 10.25625/9vekun/nhr6nv
title: LiDAR_metrics.tab

description: :unav
DOI: 10.25625/9vekun/q5fbzo
title: sound_transmission_area.tab

description: :unav
DOI: 10.25625/9vekun/9sz2si
title: Sound Levels ultrasound LA - test_tones.tab

description: :unav
DOI: 10.25625/9vekun/oktdov
title: Sound Levels ultrasound LA - ambient_noise.tab

description: :unav
DOI: 10.6084/m9.figshare.21202928
title: CONSUMO DE NOOTROPICOS EN ESTUDIANTES UNIVERSITARIOS

description: ESTADO DEL ARTE ACERCA DEL CONSUMO DE NOOTROPICOS EN ESTUDIANTES UNIVERSITARIOS
DOI: 10.6084/m9.figshare.21202928.v1
title: CONSUMO DE NOOTROPICOS EN ESTUDIANTES UNIVERSITARIOS

description: ESTADO DEL ARTE ACERCA DEL CONSUMO DE NOOTROPICOS EN ESTUDIANTES UNIVERSITARIOS
DOI: 10.5255/ukda-sn-853108
title: Precarious Places: Social Cohesion, Wellbeing and Place Attachment in Refugee-Host interactions, 2017

description: This collection contains English transcripts of twenty semi-structured interviews carried out in the Bekaa Valley in Lebanon during July 2017. Four different groups of people were approached for interview: Syrian refugees, Palestinian Refugees from Syria, Lebanese host communities and Palestinian Refugees from Lebanon. The interviews took place with households living in informal tented settlements and privately-rented accommodation. We asked questions about sense of place, mobility and meaningful locations. We wanted to know whether and how respondents formed attachments to meaningful places, the characteristics of those places, and the feelings they evoked.
DOI: 10.34740/kaggle/dsv/4294601
title: 2021 World Population (updated daily)
DOI: 10.6084/m9.figshare.19303802
title: Actkins et al. PCOS Comorbidities Supplementary Material

description: This document contains supplementary material for "Comorbidity Differences by Race and Ethnicity Among Polycystic Ovary Syndrome Patients".
DOI: 10.6084/m9.figshare.19303802.v2
title: Actkins et al. PCOS Comorbidities Supplementary Material

description: This document contains supplementary material for "Comorbidity Differences by Race and Ethnicity Among Polycystic Ovary Syndrome Patients".
DOI: 10.6084/m9.figshare.19303802.v1
title: Actkins et al. PCOS Comorbidities Supplementary Material

description: This document contains supplementary material for "Comorbidity Differences by Race and Ethnicity Among Polycystic Ovary Syndrome Patients".
DOI: 10.15129/4b0dbf49-377c-4642-b95d-0ac8ef2e11c6
title: Data for: "Ratiometric imaging of minor groove binders in mammalian cells using Raman microscopy"

description: This data was generated for the publication of a research article of the same title and investigates the detection of Strathclyde-Minor Groove Binders using Raman microscopy. Raman spectral data was acquired using a Renishaw InVia microscope system controlled using Renishaw WiRE 4.4 software. Spectral and imaging datasets are collated as Excel file format (.exe) or text file format (.txt). SRS images were acquired using a Leica multiphoton microscope. SRS images are provided in .tif file format with post-processing performed using ImageJ. Embargo end date 31/12/22
DOI: 10.5281/zenodo.7157501
title: drosera_tokaiensis_zanfona_1.fasta.gz

description: .
DOI: 10.5281/zenodo.7157500
title: drosera_tokaiensis_zanfona_1.fasta.gz

description: .
DOI: 10.34740/kaggle/dsv/4294699
title: Elon Musk Tweets
DOI: 10.3886/e156321v1
title: Supplementary Data for "Child Care Subsidies and Child Skill Accumulation in One- and Two-Parent Families"

description: Supplementary data for online appendix of "Child Care Subsidies and Child Skill Accumulation in One- and Two-Parent Families"
DOI: 10.6084/m9.figshare.7638134.v2
title: Travel time to cities and ports in the year 2015

description: travel_time_to_cities_x.tif (x has values from 1 to 12)The value of each pixel is the estimated travel time in minutes to the nearest urban area in 2015. There are 12 data layers based on different sets of urban areas, defined by their population in year 2015 (see PDF report).<br><br>travel_time_to_ports_x (x ranges from 1 to 5)<br>The value of each pixel is the estimated travel time to the nearest port in 2015. There are 5 data layers based on different port sizes.<br><br>FormatRaster Dataset, GeoTIFF, LZW compressed<br><br>UnitMinutes<br><br>Data typeByte (16 bit Unsigned Integer)<br><br>No data value65535<br><br>FlagsNone<br><br>Spatial resolution30 arc seconds<br><br>Spatial extentUpper left -180, 85<br>Lower left -180, -60Upper right 180, 85Lower right 180, -60<br>Spatial Reference System (SRS)EPSG:4326 - WGS84 - Geographic Coordinate System (lat/long)<br>Temporal resolution2015<br>Temporal extentUpdates may follow for future years, but these are dependent on the availability of updated inputs on travel times and city locations and populations.<br>MethodologyTravel time to the nearest city or port was estimated using an accumulated cost function (accCost) in the gdistance R package (van Etten, 2018). This function requires two input datasets: (i) a set of locations to estimate travel time to and (ii) a transition matrix that represents the cost or time to travel across a surface. The set of locations were based on populated urban areas in the 2016 version of the Joint Research Centre’s Global Human Settlement Layers (GHSL) datasets (Pesaresi and Freire, 2016) that represent low density (LDC) urban clusters and high density (HDC) urban areas (https://ghsl.jrc.ec.europa.eu/datasets.php). These urban areas were represented by points, spaced at 1km distance around the perimeter of each urban area.<br>Marine ports were extracted from the 26th edition of the World Port Index (NGA, 2017) which contains the location and physical characteristics of approximately 3,700 major ports and terminals. Ports are represented as single points<br>The transition matrix was based on the friction surface (https://map.ox.ac.uk/research-project/accessibility_to_cities) from the 2015 global accessibility map (Weiss et al, 2018). The R code used to generate the 12 travel time maps is included in the report “A suite of global accessibility indicators for sustainable rural development” (Nelson, 2019) that can be downloaded with these data layers.<br>
DOI: 10.5281/zenodo.4564441
title: R2R3 MYB dataset and phylogeny for Azolla filiculoides in the perspective of land plant evolution

description: R2R3 MYB dataset and phylogeny for Azolla filiculoides in the perspective of land plant evolution as published in https://doi.org/10.3389/fpls.2021.693039
DOI: 10.5281/zenodo.4564440
title: R2R3 MYB dataset and phylogeny for Azolla filiculoides in the perspective of land plant evolution

description: R2R3 MYB dataset and phylogeny for Azolla filiculoides in the perspective of land plant evolution as published in https://doi.org/10.3389/fpls.2021.693039
DOI: 10.6073/pasta/cca55a632e9066ff54677258f58009d2
title: Soil extracellular enzyme activities in plots dominated by trees that associate with arbuscular mycorrhizal or ectomycorrhizal fungi in the N fertilized and reference watershed at the Fernow Experimental Forest, WV.

description: Our objective was to detect possible differences in N fertilization responses of soil extracellular enzymes in plots dominated by trees that associate with arbuscular mycorrhizal fungi (AM) or ectomycorrhizal fungi (ECM). To do this, we established a plot network of 6 AM and 6 ECM dominated 10 x 10 m plots in both the reference and N fertilized watersheds (N=24 plots) at the Fernow Experimental Forest, Parsons, WV. We assayed the potential activity of hydrolytic enzymes that release N (﻿N-acetylglucosaminidase; NAG), phosphorus (acid phosphatase; AP), and simple carbon (ß-glucosidase; BG). In addition, we measured microbial allocation to complex C degrading oxidative enzymes phenol oxidase and peroxidase. The activities of these enzymes were measured separately in bulk mineral, rhizosphere, and organic horizon soils during the growing season in 2017.
DOI: 10.5281/zenodo.7157580
title: REMODEL. WP5. Cable Manipulation Planning, Execution and Interactive Perception. T5-2. Cable grasping. Data related to a paper published in MDPI Electronics 2021

description: The datasets contain data for the normalization of tactile voltages, the training dataset for the diameter classifier, and data recorded during the experiment related to the publication: A. Cirillo, G. Laudante, and S. Pirozzi, “Tactile sensor data interpretation for estimation of wire features,” Electronics, vol. 10, no. 12, art. 1458, June 2021. (DOI: 10.3390/electronics10121458)
DOI: 10.5281/zenodo.7157581
title: REMODEL. WP5. Cable Manipulation Planning, Execution and Interactive Perception. T5-2. Cable grasping. Data related to a paper published in MDPI Electronics 2021

description: The datasets contain data for the normalization of tactile voltages, the training dataset for the diameter classifier, and data recorded during the experiment related to the publication: A. Cirillo, G. Laudante, and S. Pirozzi, “Tactile sensor data interpretation for estimation of wire features,” Electronics, vol. 10, no. 12, art. 1458, June 2021. (DOI: 10.3390/electronics10121458)
DOI: 10.5281/zenodo.7157594
title: REMODEL. WP6. Sensory Systems and Mechatronic Tools. T6-2. Development and optimization of sensory system components. Data related to a paper published in MDPI Machines 2021

description: The datasets contain the data related to the experiment presented in the publication: A. Cirillo, G. Laudante, and S. Pirozzi, “Proximity sensor for thin wire recognition and manipulation,” Machines, vol. 9, no. 9, art. 188, Sept. 2021. (DOI: 10.3390/machines9090188)
DOI: 10.5281/zenodo.7157595
title: REMODEL. WP6. Sensory Systems and Mechatronic Tools. T6-2. Development and optimization of sensory system components. Data related to a paper published in MDPI Machines 2021

description: The datasets contain the data related to the experiment presented in the publication: A. Cirillo, G. Laudante, and S. Pirozzi, “Proximity sensor for thin wire recognition and manipulation,” Machines, vol. 9, no. 9, art. 188, Sept. 2021. (DOI: 10.3390/machines9090188)
DOI: 10.18434/mds2-2553
title: Distributed Sensing of Radio Spectrum Occupancy Amid COVID-19
DOI: 10.34740/kaggle/dsv/4294849
title: COVID Vaccination in World (updated daily)
DOI: 10.34740/kaggle/dsv/4294853
title: Russian Invasion of Ukraine
DOI: 10.5281/zenodo.7157687
title: APLxmi | Apple Inflorescence Dataset

description: <strong>Apple Inflorescence Dataset.</strong> This dataset was collected from a orchard located in Prazeres de Aljubarrota, Alcobaça,Portugal, on two different days: 21 and 28 April, 2022. The images were taken with a Xiaomi Redmi Note 7 smartphone with the following dual camera specs: 48 MP, f/1.8, (wide), 1/2.0", 0.8µm, PDAF and 5 MP, f/2.2, (depth).
DOI: 10.5281/zenodo.7157686
title: APLxmi | Apple Inflorescence Dataset

description: <strong>Apple Inflorescence Dataset.</strong> This dataset was collected from a orchard located in Prazeres de Aljubarrota, Alcobaça,Portugal, on two different days: 21 and 28 April, 2022. The images were taken with a Xiaomi Redmi Note 7 smartphone with the following dual camera specs: 48 MP, f/1.8, (wide), 1/2.0", 0.8µm, PDAF and 5 MP, f/2.2, (depth).
DOI: 10.5281/zenodo.7157761
title: Data for 'How stable are magnetic pore fabrics?'

description: Supplementary data for the manuscript; refer to the manuscript for a detailed description
DOI: 10.34740/kaggle/dsv/4294879
title: Tales from the Pizza Guy
DOI: 10.6084/m9.figshare.21295416.v1
title: SData10

description: BGCs retrieved in our study, and 4 similar ones
DOI: 10.6084/m9.figshare.21295338
title: SData5

description: BiG-SCAPE networks and annotations
DOI: 10.6084/m9.figshare.21295350.v1
title: SData6

description: Genomes from the phylum Nitrospirota available in GTDB v202 and from our study
DOI: 10.6084/m9.figshare.21295404
title: SData9

description: BGCs retrieved in the phylum Myxococota
DOI: 10.6084/m9.figshare.21295404.v1
title: SData9

description: BGCs retrieved in the phylum Myxococota
DOI: 10.6084/m9.figshare.21295416
title: SData10

description: BGCs retrieved in our study, and 4 similar ones
DOI: 10.6084/m9.figshare.21295287
title: SData1

description: MAGs analyzed in this study.
DOI: 10.6084/m9.figshare.21295329
title: SData4

description: BiG-SLICE query network and annotation
DOI: 10.6084/m9.figshare.21295350
title: SData6

description: Genomes from the phylum Nitrospirota available in GTDB v202 and from our study
DOI: 10.6084/m9.figshare.21295314
title: SData2

description: BGCs retrieved retrieved from AS MAGs in this study.
DOI: 10.6084/m9.figshare.21295320
title: SData3

description: Results of DIAMOND BLAST search of the "core" genes of our terpene BGCs against NCBI nr database
DOI: 10.6084/m9.figshare.21295329.v1
title: SData4

description: BiG-SLICE query network and annotation
DOI: 10.6084/m9.figshare.21295287.v1
title: SData1

description: MAGs analyzed in this study.
DOI: 10.6084/m9.figshare.21295314.v1
title: SData2

description: BGCs retrieved retrieved from AS MAGs in this study.