cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24906713.v1
title: Cost-utility analysis of sacituzumab govitecan versus chemotherapy for the treatment of metastatic triple-negative breast cancer in Singapore

description: To assess the cost-effectiveness of sacituzumab govitecan for treating relapsed or refractory metastatic triple-negative breast cancer (TNBC) in Singapore. A three-state partitioned survival model was developed to evaluate the cost-effectiveness of sacituzumab govitecan from a healthcare system perspective over 5 years. Clinical inputs were obtained from the ASCENT trial. Health state utilities were retrieved from the literature and direct costs were sourced from public healthcare institutions in Singapore. Sensitivity and scenario analyses were conducted to explore the impact of uncertainties and assumptions on cost-effectiveness results. Compared with single-agent chemotherapy, sacituzumab govitecan was associated with a base-case incremental cost-effectiveness ratio (ICER) of S$328,000 (US$237,816) per quality-adjusted life year (QALY) gained. One-way sensitivity analyses showed that the ICER was most sensitive to the cost of sacituzumab govitecan and progression-free utility values. Regardless of variation in these parameters, the ICER remained high, and a substantial price reduction was required to reduce the ICER. At its current price, sacituzumab govitecan does not represent a cost-effective treatment for relapsed or refractory metastatic TNBC in Singapore. Our findings will be useful to inform funding decisions alongside other factors including clinical effectiveness, safety, and budget impact considerations.
DOI: 10.6084/m9.figshare.24906713
title: Cost-utility analysis of sacituzumab govitecan versus chemotherapy for the treatment of metastatic triple-negative breast cancer in Singapore

description: To assess the cost-effectiveness of sacituzumab govitecan for treating relapsed or refractory metastatic triple-negative breast cancer (TNBC) in Singapore. A three-state partitioned survival model was developed to evaluate the cost-effectiveness of sacituzumab govitecan from a healthcare system perspective over 5 years. Clinical inputs were obtained from the ASCENT trial. Health state utilities were retrieved from the literature and direct costs were sourced from public healthcare institutions in Singapore. Sensitivity and scenario analyses were conducted to explore the impact of uncertainties and assumptions on cost-effectiveness results. Compared with single-agent chemotherapy, sacituzumab govitecan was associated with a base-case incremental cost-effectiveness ratio (ICER) of S$328,000 (US$237,816) per quality-adjusted life year (QALY) gained. One-way sensitivity analyses showed that the ICER was most sensitive to the cost of sacituzumab govitecan and progression-free utility values. Regardless of variation in these parameters, the ICER remained high, and a substantial price reduction was required to reduce the ICER. At its current price, sacituzumab govitecan does not represent a cost-effective treatment for relapsed or refractory metastatic TNBC in Singapore. Our findings will be useful to inform funding decisions alongside other factors including clinical effectiveness, safety, and budget impact considerations.
DOI: 10.6084/m9.figshare.24600272
title: Social care data in the UK; current landscape, challenges, and future recommendations

description: Social care in the United Kingdom (UK) refers to care provided due to age, illness, disability, or other circumstances. Social care provision offers an intermediary step between hospital discharge and sufficient health for independent living, which subsequently helps with National Health Service (NHS) bed capacity issues. UK Health Technology Assessments (HTAs) do not typically include social care data, possibly due to a lack of high-quality, accessible social care data to generate evidence suitable for submissions. We identified and characterized secondary sources of UK social care data suitable for research (as of 2021). Sources were identified and profiled by desk research, supplemented by information from custodians and data experts. We identified twenty-one sources; six high potential (three national, three regional data sources), five future potential, seven limited potential, and three not considered further (outdated or lacking social care data). Despite identifying numerous sources of social care data across the UK, opportunities and access for researchers appeared limited and could be improved. This would facilitate a deeper understanding of the clinical and economic burden of disease, the impact of medicines and vaccines on social care, enable better-informed HTA submissions and more efficient allocation of NHS and local council social care resources.
DOI: 10.6084/m9.figshare.24600272.v1
title: Social care data in the UK; current landscape, challenges, and future recommendations

description: Social care in the United Kingdom (UK) refers to care provided due to age, illness, disability, or other circumstances. Social care provision offers an intermediary step between hospital discharge and sufficient health for independent living, which subsequently helps with National Health Service (NHS) bed capacity issues. UK Health Technology Assessments (HTAs) do not typically include social care data, possibly due to a lack of high-quality, accessible social care data to generate evidence suitable for submissions. We identified and characterized secondary sources of UK social care data suitable for research (as of 2021). Sources were identified and profiled by desk research, supplemented by information from custodians and data experts. We identified twenty-one sources; six high potential (three national, three regional data sources), five future potential, seven limited potential, and three not considered further (outdated or lacking social care data). Despite identifying numerous sources of social care data across the UK, opportunities and access for researchers appeared limited and could be improved. This would facilitate a deeper understanding of the clinical and economic burden of disease, the impact of medicines and vaccines on social care, enable better-informed HTA submissions and more efficient allocation of NHS and local council social care resources.
DOI: 10.6084/m9.figshare.24943067
title: Capturing the holistic value of biosimilars in Europe – part 1: a historical perspective

description: Approved biosimilars exhibit comparable efficacy, safety, and immunogenicity to reference products. This report provides perspectives on the societal value of biosimilars within Europe and potential factors that have influenced market dynamics. An independent, self-administered survey or one-on-one in-depth interview was used to collect viewpoints about the impact of biosimilar medicines within European markets. Key insights were also sought from an expert panel of European stakeholders. Survey respondents were clinicians, pharmacists, and payers from Europe (<i>N</i> = 103). Perceived benefits of biosimilars included increased access to innovative medicines (73% of respondents) or biologic treatments (66%). Biosimilar competition was thought to expand access to biologics (~50% of respondents) or drug combinations (~36%) and reduce biologic access time (34%). Key drivers of biologic access after biosimilar competition included increased biologic awareness (51%) and changes to prescribing guidelines (37%) and/or treatment paradigms (28%). The expert panel developed a market maturity framework of biosimilar adoption/opportunities comprising three stages: ‘Invest,’ ‘Expand,’ and ‘Harvest.’ Findings were supported by published literature. In Europe, the perceptions of well-informed survey/interview respondents are that biosimilars have improved patient outcomes via increased access to biologics and innovative biologic products, contributing to earlier and longer treatment of a broader population.
DOI: 10.6084/m9.figshare.24943067.v2
title: Capturing the holistic value of biosimilars in Europe – part 1: a historical perspective

description: Approved biosimilars exhibit comparable efficacy, safety, and immunogenicity to reference products. This report provides perspectives on the societal value of biosimilars within Europe and potential factors that have influenced market dynamics. An independent, self-administered survey or one-on-one in-depth interview was used to collect viewpoints about the impact of biosimilar medicines within European markets. Key insights were also sought from an expert panel of European stakeholders. Survey respondents were clinicians, pharmacists, and payers from Europe (<i>N</i> = 103). Perceived benefits of biosimilars included increased access to innovative medicines (73% of respondents) or biologic treatments (66%). Biosimilar competition was thought to expand access to biologics (~50% of respondents) or drug combinations (~36%) and reduce biologic access time (34%). Key drivers of biologic access after biosimilar competition included increased biologic awareness (51%) and changes to prescribing guidelines (37%) and/or treatment paradigms (28%). The expert panel developed a market maturity framework of biosimilar adoption/opportunities comprising three stages: ‘Invest,’ ‘Expand,’ and ‘Harvest.’ Findings were supported by published literature. In Europe, the perceptions of well-informed survey/interview respondents are that biosimilars have improved patient outcomes via increased access to biologics and innovative biologic products, contributing to earlier and longer treatment of a broader population.
DOI: 10.6084/m9.figshare.24298393
title: Canadian English translation and linguistic validation of the 13-MD to measure global health-related quality of life

description: The 13-MD is a new instrument designed to measure more globally the various aspects of the health-related quality of life. Its structure is balanced around physical, mental, and social aspects of health. To translate the 13-MD into Canadian English and to ensure that it is conceptually equivalent to the original version in Canadian French. Forward and back translations were conducted. A linguistic validation was performed in both Canadian French and Canadian English following an iterative process. This validation was conducted with 15 participants in each group (French and English speakers) using face-to-face cognitive debriefing interviews. This process was done in accordance with academic standards. The two forward translations resulted in 35.8% of identical sentences (59/165). Back translation indicated that 83.6% of the sentences were identical or almost identical to the original Canadian French version. The review of the back translation led to a few changes in the reconciled forward translation (4/165) and the original version (11/165), while the linguistic validation process led to 24 changes over a possibility of 165 sentences in the Canadian English version and 6 over 165 in the Canadian French version. Most changes provided were minimal and were done to ensure a better understanding of the 13-MD. The translation and linguistic validation processes were successful in creating a valid 13-MD in Canadian English (13-MD-CE) that is conceptually equivalent to the original version.
DOI: 10.6084/m9.figshare.24298393.v1
title: Canadian English translation and linguistic validation of the 13-MD to measure global health-related quality of life

description: The 13-MD is a new instrument designed to measure more globally the various aspects of the health-related quality of life. Its structure is balanced around physical, mental, and social aspects of health. To translate the 13-MD into Canadian English and to ensure that it is conceptually equivalent to the original version in Canadian French. Forward and back translations were conducted. A linguistic validation was performed in both Canadian French and Canadian English following an iterative process. This validation was conducted with 15 participants in each group (French and English speakers) using face-to-face cognitive debriefing interviews. This process was done in accordance with academic standards. The two forward translations resulted in 35.8% of identical sentences (59/165). Back translation indicated that 83.6% of the sentences were identical or almost identical to the original Canadian French version. The review of the back translation led to a few changes in the reconciled forward translation (4/165) and the original version (11/165), while the linguistic validation process led to 24 changes over a possibility of 165 sentences in the Canadian English version and 6 over 165 in the Canadian French version. Most changes provided were minimal and were done to ensure a better understanding of the 13-MD. The translation and linguistic validation processes were successful in creating a valid 13-MD in Canadian English (13-MD-CE) that is conceptually equivalent to the original version.
DOI: 10.6084/m9.figshare.24550751.v1
title: Developing the Lebanese health economic evaluation guideline

description: To report on the process of developing the Lebanese Economic Evaluation Guideline (LEEG), and to provide relevant material that could assist guideline developers in the future. The development of the LEEG closely followed the process proposed by the World Health Organization, i.e. to set up a Guideline Development Group (composed of three Lebanese experts), to establish the rationale for developing the guideline in Lebanon, to identify its scope, to search and retrieve evidence through two systematic reviews, to assess and present the evidence, to translate the evidence into guidelines and recommendations through a deliberative process, and to consult international experts. The deliberative process included a survey, an in-person interview, and a consensus workshop with 16 Lebanese key stakeholders. Data was collected and quantitative analysis was conducted using SPSS software. International experts from Maastricht University - The Netherlands were consulted for issuing the LEEG. Supported by the Lebanese Ministry of Public Health (MoPH), the LEEG will be available for public consultation on the MoPH’s webpage, and a final version will be made available thereafter. Clear and transparent reporting of the guideline development process should support international organizations as well as other developers in establishing their guidelines within their national context.
DOI: 10.6084/m9.figshare.24550751
title: Developing the Lebanese health economic evaluation guideline

description: To report on the process of developing the Lebanese Economic Evaluation Guideline (LEEG), and to provide relevant material that could assist guideline developers in the future. The development of the LEEG closely followed the process proposed by the World Health Organization, i.e. to set up a Guideline Development Group (composed of three Lebanese experts), to establish the rationale for developing the guideline in Lebanon, to identify its scope, to search and retrieve evidence through two systematic reviews, to assess and present the evidence, to translate the evidence into guidelines and recommendations through a deliberative process, and to consult international experts. The deliberative process included a survey, an in-person interview, and a consensus workshop with 16 Lebanese key stakeholders. Data was collected and quantitative analysis was conducted using SPSS software. International experts from Maastricht University - The Netherlands were consulted for issuing the LEEG. Supported by the Lebanese Ministry of Public Health (MoPH), the LEEG will be available for public consultation on the MoPH’s webpage, and a final version will be made available thereafter. Clear and transparent reporting of the guideline development process should support international organizations as well as other developers in establishing their guidelines within their national context.
DOI: 10.5281/zenodo.10570253
title: СОВРЕМЕННЫЕ ПРОБЛЕМЫ И ВОЗМОЖНОСТИ ПРЕПОДАВАНИЯ ИНОСТРАННЫХ ЯЗЫКОВ В СИСТЕМЕ НЕПРЕРЫВНОГО ОБРАЗОВАНИЯ
DOI: 10.5281/zenodo.10570254
title: СОВРЕМЕННЫЕ ПРОБЛЕМЫ И ВОЗМОЖНОСТИ ПРЕПОДАВАНИЯ ИНОСТРАННЫХ ЯЗЫКОВ В СИСТЕМЕ НЕПРЕРЫВНОГО ОБРАЗОВАНИЯ
DOI: 10.34740/kaggle/dsv/7482471
title: BBC News
DOI: 10.5281/zenodo.10570261
title: O'ZBEK PEDAGOGIKASINI RAQAMLASHTIRISHDA MODDIY TEXNIK BAZASINI TAKOMILLASHTIRISH VA TA'LIM ZAHIRALARINI YARATISH
DOI: 10.5281/zenodo.10570262
title: O'ZBEK PEDAGOGIKASINI RAQAMLASHTIRISHDA MODDIY TEXNIK BAZASINI TAKOMILLASHTIRISH VA TA'LIM ZAHIRALARINI YARATISH
DOI: 10.5281/zenodo.10570268
title: IMPROVING THE LUBRICATING PROPERTIES OF TRANSMISSION OILS USED IN AGRICULTURAL MACHINERY
DOI: 10.5281/zenodo.10570269
title: IMPROVING THE LUBRICATING PROPERTIES OF TRANSMISSION OILS USED IN AGRICULTURAL MACHINERY
DOI: 10.5281/zenodo.10570272
title: IQTISODIYOTNI ISLOH QILISHDA QISHLOQ XO'JALIGI MAHSULOTLARINI ISHLAB CHIQARISH SIFATINI OSHIRISH
DOI: 10.5281/zenodo.10570273
title: IQTISODIYOTNI ISLOH QILISHDA QISHLOQ XO'JALIGI MAHSULOTLARINI ISHLAB CHIQARISH SIFATINI OSHIRISH
DOI: 10.5281/zenodo.10570278
title: DIGITAL ECONOMIC INFRASTRUCTURE. THE EFFECT OF THE DIGITAL ECONOMY ON EDUCATION
DOI: 10.5281/zenodo.10570279
title: DIGITAL ECONOMIC INFRASTRUCTURE. THE EFFECT OF THE DIGITAL ECONOMY ON EDUCATION
DOI: 10.5517/ccdc.csd.cc2gv3bs
title: CCDC 2289205: Experimental Crystal Structure Determination

description: Related Article: Zhongchen Zhao, Zonghan Zhang, Tian Xu, Wenbin Wang, Baofeng Wang, Xuebin Yu|2024|J.Am.Chem.Soc.|146|2257|doi:10.1021/jacs.3c13003
description: Related Article: zhongchen zhao|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2gz0r7
title: CCDC 2292969: Experimental Crystal Structure Determination

description: Related Article: Dinesh Gopichand Thakur, Nileshkumar B. Rathod, Sachinkumar D. Patel, Dharmik M. Patel, Raj N. Patel, Mahesh A. Sonawane, Subhash Chandra Ghosh|2024|J.Org.Chem.|89|1058|doi:10.1021/acs.joc.3c02139
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.10570229
title: Benchmarking dataset for multiskilled workforce planning with uncertain demand

description: These datasets are related to the Data Article entitled: “A benchmark dataset for the retail multiskilled personnel planning under uncertain demand”, submitted to the Data Science Journal. This data article describes datasets from a home improvement retailer located in Santiago, Chile. The datasets were developed to solve a multiskilled personnel assignment problem (MPAP) under uncertain demand. Notably, these datasets were used in the published article "Multiskilled personnel assignment problem under uncertain demand: A benchmarking analysis" authored by Henao et al. (2022). Moreover, the datasets were also used in the published articles authored by Henao et al. (2016) and Henao et al. (2019) to solve MPAPs.

The datasets include real and simulated data. Regarding the real dataset, it includes information about the store size, number of employees, employment-contract characteristics, mean value of weekly hours demand in each department, and cost parameters. Regarding the simulated datasets, they include information about the random parameter of weekly hours demand in each store department. The simulated data are presented in 18 text files classified by: (i) Sample type (in-sample or out-of-sample). (ii) Truncation-type method (zero-truncated or percentile-truncated). (iii) Coefficient of variation (5, 10, 20, 30, 40, 50%).
DOI: 10.5281/zenodo.8317622
title: Benchmarking dataset for multiskilled workforce planning with uncertain demand

description: These datasets are related to the Data Article entitled: “A benchmark dataset for the retail multiskilled personnel planning under uncertain demand”, submitted to the Data Science Journal. This data article describes datasets from a home improvement retailer located in Santiago, Chile. The datasets were developed to solve a multiskilled personnel assignment problem (MPAP) under uncertain demand. Notably, these datasets were used in the published article "Multiskilled personnel assignment problem under uncertain demand: A benchmarking analysis" authored by Henao et al. (2022). Moreover, the datasets were also used in the published articles authored by Henao et al. (2016) and Henao et al. (2019) to solve MPAPs.

The datasets include real and simulated data. Regarding the real dataset, it includes information about the store size, number of employees, employment-contract characteristics, mean value of weekly hours demand in each department, and cost parameters. Regarding the simulated datasets, they include information about the random parameter of weekly hours demand in each store department. The simulated data are presented in 18 text files classified by: (i) Sample type (in-sample or out-of-sample). (ii) Truncation-type method (zero-truncated or percentile-truncated). (iii) Coefficient of variation (5, 10, 20, 30, 40, 50%).
DOI: 10.5281/zenodo.8317623
title: Benchmarking dataset for multiskilled workforce planning with uncertain demand

description: This dataset is related with the Data Article entitled: “A benchmark dataset for the retail multiskilled personnel planning under uncertain demand”, which was submitted to Data Science Journal. This data article describes datasets from a home improvement retail store located in Santiago, Chile. The datasets have been developed to solve a multiskilled personnel assignment problem (MPAP) under uncertain demand. Particularly, this database is related to the published article "Multiskilled personnel assignment problem under uncertain demand: A benchmarking analysis" developed by Henao et al. (2022). The datasets contain real and simulated data. Regarding the real dataset, it includes information about the store size, number of employees, employment-contract characteristics, mean value of weekly hours demand in each department, and cost parameters. Regarding the simulated datasets, they include information about the random parameter of weekly hours demand in each store department. The simulated data are presented in 18 text files classified by: (i) Sample type (in-sample or out-of-sample). (ii) Truncation-type method (zero-truncated or percentile-truncated). (iii) Coefficient of variation (5, 10, 20, 30, 40, 50%).
DOI: 10.25493/th1n-v8p
title: Three-dimensional topography of corticopontine projections from the rat sensorimotor cortex (S1, S2, M1) (v3)

description: 3D reconstructed point coordinate data representing the spatial relationships of rat corticopontine projections originating from the primary somatosensory cortex (S1), the secondary somatosensory cortex (S2), and the primary motor cortex (M1). The corticopontine projections were anterogradely labeled following dual tracer injections into S1 and S2 or M1. The data demonstrate that whisker-related projections from S1 and M1 are largely segregated, but at some locations adjoining and partly overlapping. Furthermore, S1 contributes significantly more corticopontine projections than M1. Projections from corresponding representations in S1 and S2 terminate in similar parts of the pontine nuclei and display considerable amounts of spatial overlap.