cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5006613
title: Simulation and analysis data set for apo-conformational kinetics and gated ligand binding to HIV-1 protease

description: The data set provided here accompanies a study described in the manuscript: S. Kashif Sadiq, Abraham Muñiz Chicharro, Patrick Friedrich, Rebecca Wade, A multiscale approach for computing gated ligand binding from molecular dynamics and Brownian dynamics simulations. (2021) Preprint available: https://doi.org/10.1101/2021.06.22.449380 This study combines molecular dynamics MD simulations and associated conformational analyses and Markov state models (MSMs) with Brownian dynamics (BD) simulations to compute conformation gated ligand association kinetics to HIV-1 protease. To download the data, go to a directory where you would like to download the files. Then for each of the provided tar files enter the following command: tar xvf $X.tar where $X is the name prefix of the corresponding tar file. The unpacked data set creates a ./data sub-directory which itself contains two further sub-directories: MD and BD. Please see README.txt files within these sub directories for further instructions on the software tools and scripts that have been provided therein for using and reproducing the data set. The MD README.txt is found within: data_MD_MSM_analysis.tar, the BD README.txt is found within: data_BD_examples.tar. Please note, the python Jupyter notebook and associated module for further analysis of the MSM from the pre-defined feature set calculated in the study as well as other analyses can also be found at: https://github.com/kashifsadiq/hiv1pr-msm/ MD trajectory files are provided for further analysis but are not required to reproduce the MSM and conformational analyses reported in the study. To facilitate overview, MSM analysis has been stored in several object files. To exactly reproduce the reported MD/MSM analyses, untar only the 1) data_MD_MSM_analysis.tar and 2) data_MD_MSMobj.tar files and work through the python Jupyter notebook.
DOI: 10.5281/zenodo.5006612
title: Simulation and analysis data set for apo-conformational kinetics and gated ligand binding to HIV-1 protease

description: The data set provided here accompanies a study described in the manuscript: S. Kashif Sadiq, Abraham Muñiz Chicharro, Patrick Friedrich, Rebecca Wade, A multiscale approach for computing gated ligand binding from molecular dynamics and Brownian dynamics simulations. (2021) Preprint available: https://doi.org/10.1101/2021.06.22.449380 This study combines molecular dynamics MD simulations and associated conformational analyses and Markov state models (MSMs) with Brownian dynamics (BD) simulations to compute conformation gated ligand association kinetics to HIV-1 protease. To download the data, go to a directory where you would like to download the files. Then for each of the provided tar files enter the following command: tar xvf $X.tar where $X is the name prefix of the corresponding tar file. The unpacked data set creates a ./data sub-directory which itself contains two further sub-directories: MD and BD. Please see README.txt files within these sub directories for further instructions on the software tools and scripts that have been provided therein for using and reproducing the data set. The MD README.txt is found within: data_MD_MSM_analysis.tar, the BD README.txt is found within: data_BD_examples.tar. Please note, the python Jupyter notebook and associated module for further analysis of the MSM from the pre-defined feature set calculated in the study as well as other analyses can also be found at: https://github.com/kashifsadiq/hiv1pr-msm/ MD trajectory files are provided for further analysis but are not required to reproduce the MSM and conformational analyses reported in the study. To facilitate overview, MSM analysis has been stored in several object files. To exactly reproduce the reported MD/MSM analyses, untar only the 1) data_MD_MSM_analysis.tar and 2) data_MD_MSMobj.tar files and work through the python Jupyter notebook.
DOI: 10.5291/ill-data.1-02-165
title: Stress Distribution and Strain Mapping in Porous Granular Rocks.
DOI: 10.5291/ill-data.1-05-10
title: Characterisation of claystone crack self-sealing due to water induced swelling, implication for deep nuclear waste disposal
DOI: 10.5291/ill-data.4-02-461
title: A study of high energy spin excitations in FeSe
DOI: 10.5291/ill-data.4-05-752
title: Quantum spin liquid in Seff=1/2 frustrated antiferromagnets with strong spin-orbit coupling
DOI: 10.5291/ill-data.4-05-779
title: Magnetic moment fragmentation in (NdLa)2Zr2O7 pyrochlore magnets
DOI: 10.5291/ill-data.5-32-796
title: Short-range magnetic correlations in the 'large-D' 1D system Sr3NitO6
DOI: 10.5291/ill-data.5-53-244
title: Er magnetism in the Iridate Pyrochlore Er2Ir2O7
DOI: 10.5291/ill-data.6-02-600
title: Dynamics in water-nanoparticles colloidal suspensions.
DOI: 10.5291/ill-data.6-03-424
title: Collective dynamics in room temperature ionic liquids
DOI: 10.5291/ill-data.7-01-511
title: Acoustic phonon dispersion along the chain of fully deuterated cellulose crystal
DOI: 10.5291/ill-data.7-05-517
title: Understanding the growth of supramolecular networks and graphitic carbon nitride: The dynamics of melamine on graphite
DOI: 10.5291/ill-data.7-05-475
title: Symmetry and Size Effects in the Dynamics of Adsorbed PAHs: Fluoranthene on Graphite
DOI: 10.5291/ill-data.8-02-847
title: Phospholipid bilayer of pulmonary surfactant: the effect of SP-B protein and Polymyxin B
DOI: 10.5291/ill-data.8-02-788
title: Lamellar neutron diffraction studies of a simplified (4-component) model stratum corneal system
DOI: 10.5291/ill-data.8-02-643
title: Lipid organisation in the stratum corneum
DOI: 10.5291/ill-data.9-10-1646
title: Pressure-induced phase transition of micelle-forming thermoresponsive PMMA-b-PNIPAM diblock copolymers in aqueous solution
DOI: 10.5291/ill-data.9-10-1514
title: Structure, temporal fluctuation and vibrational spectrum of the surfactant shell ofPbS nanocrystals in solution
DOI: 10.5291/ill-data.9-10-1465
title: Effect of surfactant head group onthe location of steroidal drugs into monolayers of surfactant
DOI: 10.5291/ill-data.9-10-1435
title: Location of steroidal molecules in monolayers of anionic and cationic surfactant
DOI: 10.5291/ill-data.9-10-1348
title: Location of various steroidal molecules in monolayers of surfactant
DOI: 10.34740/kaggle/dsv/2397050
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.5291/ill-data.9-12-531
title: Formation of cellulose-starch gels and the effect of surfactant
DOI: 10.5291/ill-data.9-12-498
title: Structure, temporal fluctuation and vibrational spectrum of the surfactant shell of PbS nanocrystals in solution
DOI: 10.5291/ill-data.9-13-436
title: Long-chain alcohols in phospholipid bilayers: effect on bilayer bending modulus
DOI: 10.5291/ill-data.9-13-589
title: Effect of an oxidized bilayer component on lipid raft formation
DOI: 10.5291/ill-data.9-13-502
title: Microdomain formation in biologically relevant lipid mixtures
DOI: 10.5291/ill-data.9-13-820
title: Elucidating electrostatic and hydrophobic interactions in protein-surfactant systems using contrast variation SANS
DOI: 10.5291/ill-data.9-13-748
title: Cation-induced changes in the structure of lipid membranes
DOI: 10.5281/zenodo.4738409
title: Dataset related to article "Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)"

description: This record contains raw data and scripts (R software) applied to get Figure 5 and Figure S8 related to article “Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)” Immune checkpoint blockade (ICB) has changed the prognosis of previously untreatable tumors. However, a fraction of patients is refractory to ICB therapy. Ongoing efforts to overcome resistance have focused on vaccination strategies using neoepitopes, although these cannot be applied on a large scale due to the "private" nature of cancer mutations. Here we show that infection of tumor cells with <em>Salmonella</em> induces the opening of membrane hemichannels and the release of proteasome-generated peptides in the extracellular milieu via the exacerbation of endoplasmic reticulum (ER)-stress and the unfolded protein response. Peptides released by cancer cells induced a strong antitumor response <em>in vivo</em>, both in mice bearing B16F10 melanomas and in dogs suffering of osteosarcoma and high-grade sarcoma. Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 released peptides capable of priming healthy donor CD8<sup>+</sup> T cells that recognize and kill human melanoma cells <em>in vitro</em> and when xenotransplanted <em>in vivo</em>, but not healthy melanocytes. Hence, we identified a novel class of tumor antigens that are generated in ER-stressed cells, such as tumor cells, and that do not induce central or peripheral tolerance, nor are presented by healthy cells.
DOI: 10.5291/ill-data.crg-2679
title: Dynamics of water highly confined in imogolite
DOI: 10.5291/ill-data.crg-2683
title: Ion dynamics in Thermotropic Ionic Liquid Crystals
DOI: 10.5291/ill-data.crg-2684
title: Dynamic properties of Li-borate glasses with a reversibility window
DOI: 10.5291/ill-data.crg-2730
title: Quasi elastic neutron scattering on dosium calcium aluminosilicate (NCAS) melts
DOI: 10.5291/ill-data.crg-2743
title: Evidencing the interface effect on the phonon dynamics in a TiO2 nanopowder material
DOI: 10.5291/ill-data.crg-2745
title: Study of the dynamic of hemoglobin hydrogel
DOI: 10.5291/ill-data.crg-2584
title: Magnetic orders in spins S=1 Kagomémagnets A2BV3F12 (A=Rb, Cs-B=K, Na)
DOI: 10.5291/ill-data.crg-2608
title: Electromagnon in GdMn2O5
DOI: 10.5291/ill-data.crg-2607
title: Temperature dependence of phonon dynamics in a Eutectic crystal.
DOI: 10.5291/ill-data.crg-2616
title: Vers l'utilisation du spectrom_etre temps de vol IN6-Sharp en mode monocristaux
DOI: 10.5291/ill-data.crg-2636
title: Low energy excitations of Seff=1/2 traingular rare-earth based antiferromagnets
DOI: 10.5291/ill-data.crg-2662
title: Structure and dynamics of the hydrogen-bond network in water crystallization arrays
DOI: 10.5291/ill-data.crg-2503
title: Inelastic neutron scattering study of dynamical properties of Fe2.5Mn0.5BO5 and Fe1.75Mn1.25BO5 ludwigites
DOI: 10.5291/ill-data.crg-2504
title: Ion dynamics in Thermotropic Ionic Liquid Crystalline Polymers
DOI: 10.5291/ill-data.crg-2567
title: vers l'utilisation du spectrometre temps de vol IN6-Sharp en mode monocristaux
DOI: 10.5291/ill-data.crg-2486
title: Structure and dynamics of the hydrogen-bond network in water crystallization arrays
DOI: 10.5291/ill-data.crg-2500
title: Magnetic lattice dynamics in HoFeO3
DOI: 10.5291/ill-data.crg-2502
title: Test : Water and Ionic Liquids in bulk and under nanometric confinement
DOI: 10.5517/ccdc.csd.cc284n69
title: CCDC 2089840: Experimental Crystal Structure Determination

description: Related Article: J. G. Malecki|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc284p26
title: CCDC 2089867: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Georgios Markopoulos, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc284p37
title: CCDC 2089868: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Georgios Markopoulos, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc284p48
title: CCDC 2089869: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Georgios Markopoulos, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc284p59
title: CCDC 2089870: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Georgios Markopoulos, Henning Hopf|2021|CSD Communication|||
DOI: 10.5281/zenodo.5070288
title: Dataset related to article "Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)"

description: This record contains raw data and scripts (R software) applied to get Figure 5 and Figure S8 related to article “Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)” Immune checkpoint blockade (ICB) has changed the prognosis of previously untreatable tumors. However, a fraction of patients is refractory to ICB therapy. Ongoing efforts to overcome resistance have focused on vaccination strategies using neoepitopes, although these cannot be applied on a large scale due to the "private" nature of cancer mutations. Here we show that infection of tumor cells with <em>Salmonella</em> induces the opening of membrane hemichannels and the release of proteasome-generated peptides in the extracellular milieu via the exacerbation of endoplasmic reticulum (ER)-stress and the unfolded protein response. Peptides released by cancer cells induced a strong antitumor response <em>in vivo</em>, both in mice bearing B16F10 melanomas and in dogs suffering of osteosarcoma and high-grade sarcoma. Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 released peptides capable of priming healthy donor CD8<sup>+</sup> T cells that recognize and kill human melanoma cells <em>in vitro</em> and when xenotransplanted <em>in vivo</em>, but not healthy melanocytes. Hence, we identified a novel class of tumor antigens that are generated in ER-stressed cells, such as tumor cells, and that do not induce central or peripheral tolerance, nor are presented by healthy cells.
DOI: 10.5517/ccdc.csd.cc284p6b
title: CCDC 2089871: Experimental Crystal Structure Determination

description: Related Article: Peter G. Jones, Georgios Markopoulos, Henning Hopf|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc285sgq
title: CCDC 2090933: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold|2021|CSD Communication|||
DOI: 10.5281/zenodo.4738408
title: Dataset related to article "Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)"

description: This record contains raw data and scripts (R software) applied to get Figure 5 and Figure S8 related to article “Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)” Immune checkpoint blockade (ICB) has changed the prognosis of previously untreatable tumors. However, a fraction of patients is refractory to ICB therapy. Ongoing efforts to overcome resistance have focused on vaccination strategies using neoepitopes, although these cannot be applied on a large scale due to the "private" nature of cancer mutations. Here we show that infection of tumor cells with <em>Salmonella</em> induces the opening of membrane hemichannels and the release of proteasome-generated peptides in the extracellular milieu via the exacerbation of endoplasmic reticulum (ER)-stress and the unfolded protein response. Peptides released by cancer cells induced a strong antitumor response <em>in vivo</em>, both in mice bearing B16F10 melanomas and in dogs suffering of osteosarcoma and high-grade sarcoma. Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 released peptides capable of priming healthy donor CD8<sup>+</sup> T cells that recognize and kill human melanoma cells <em>in vitro</em> and when xenotransplanted <em>in vivo</em>, but not healthy melanocytes. Hence, we identified a novel class of tumor antigens that are generated in ER-stressed cells, such as tumor cells, and that do not induce central or peripheral tolerance, nor are presented by healthy cells.
DOI: 10.5517/ccdc.csd.cc285shr
title: CCDC 2090934: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc2867yp
title: CCDC 2091382: Experimental Crystal Structure Determination

description: Related Article: Frank R. Fronczek|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc2869ld
title: CCDC 2091433: Experimental Crystal Structure Determination

description: Related Article: J. G. Malecki|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc286cql
title: CCDC 2091499: Experimental Crystal Structure Determination

description: Related Article: Michael Bolte, Robin Krishnathas, Hamid Nasiri|2021|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc286crm
title: CCDC 2091500: Experimental Crystal Structure Determination

description: Related Article: Michael Bolte, Rebecca Finger|2021|CSD Communication|||
DOI: 10.5291/ill-data.inter-460
title: Reflectometry measurements SiO2/SiO2 interface using RAINBOW setup
DOI: 10.5291/ill-data.uga-1
title: Effect of water on the neutron absorption of natural fibrous materials (paper)
DOI: 10.5291/ill-data.uga-8
title: Test tomography of model bus in order to identify contrast between plastic and metal and test reconstruction software
DOI: 10.5291/ill-data.uga-40
title: Perpetual Debris Flows test in neutron radiography
DOI: 10.5291/ill-data.uga-41
title: Flushthrough reinforced concrete at 30 MPa
DOI: 10.5291/ill-data.uga-42
title: Flushthrough of Callovo-oxfordian clay at 20 MPa
DOI: 10.5291/ill-data.uga-68
title: Effect of degree of saturation and stress state on swelling in Callovo-Oxfordian clay-rock
DOI: 10.5291/ill-data.uga-87
title: 3D fingering of immiscible fluids in porous media
DOI: 10.15468/j36g8v
title: A new species of Hyphessobrycon (Teleostei: Characidae) from the upper rio Tocantins drainage, with bony hooks on fins

description: This dataset contains the digitized treatments in Plazi based on the original journal article Bertaco, Vinicius A., Malabarba, Luiz R. (2005): A new species of Hyphessobrycon (Teleostei: Characidae) from the upper rio Tocantins drainage, with bony hooks on fins. Neotropical Ichthyology 3 (1): 83-88, DOI: 10.1590/S1679-62252005000100004, URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252005000100004&lng=en&tlng=en
DOI: 10.15468/6vrwwb
title: A new Synbranchus (Teleostei: Synbranchiformes: Synbranchidae) from ilha de Marajó, Pará, Brazil, with notes on its reproductive biology and larval development

description: This dataset contains the digitized treatments in Plazi based on the original journal article Favorito, Sandra E., Zanata, Angela M., Assumpção, Maria I. (2005): A new Synbranchus (Teleostei: Synbranchiformes: Synbranchidae) from ilha de Marajó, Pará, Brazil, with notes on its reproductive biology and larval development. Neotropical Ichthyology 3 (3): 319-328, DOI: 10.1590/S1679-62252005000300001, URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252005000300001&lng=en&tlng=en
DOI: 10.6084/m9.figshare.14685882
title: Dataset 17 poultry breeds.pdf

description: 14 microsatellite genotype of 645 individuals belong 17 Italian checken breeds
DOI: 10.5281/zenodo.5069877
title: Plot Data: Analysis of thin liquid films driven by SAW

description: Data of the relevant plots of the thesis
DOI: 10.5291/ill-data.1-02-313
title: In situ analysis of residual stresses relaxation and redistribution in welded joints subjected to cyclic solicitations
DOI: 10.5291/ill-data.1-05-52
title: Unveiling Processes at Particle/Aggregate Scale Controlling Hydro-Mechanical Behaviour of Compacted Clays
DOI: 10.5291/ill-data.1-05-59
title: 6Li/7Li isotopic contrast to image lithium gradients in high energy cathode cycled vs. Li metal cell using a standardised operando cell
DOI: 10.5291/ill-data.1-05-72
title: 4D quantification of desiccation cracking in clay
DOI: 10.5291/ill-data.1-05-90
title: Chemo-hydro-mechanics of partiallysaturated hydro-sensitive granularmedia
DOI: 10.5291/ill-data.1-05-27
title: Investigate the multi-phase flow in porous media using neutron imaging
DOI: 10.5291/ill-data.1-10-41
title: A new sample environment for structural studies of confined and sheared thin soft films
DOI: 10.5291/ill-data.3-07-401
title: Precise measurement of the neutron capture cross sections of 235,238U, 232Th and 54Fe at low energies
DOI: 10.5291/ill-data.3-14-413
title: The cross section of UCN in solid ortho-deuterium at T=5K
DOI: 10.5291/ill-data.4-01-1710
title: Magneto-elastic coupling in Tb3Ga5O12 garnet
DOI: 10.5291/ill-data.4-01-1735
title: Spin wave dispersion, including related quantum effect, of kagome spin ice HoAgGe by inelastic neutron scattering
DOI: 10.5291/ill-data.4-02-544
title: Spin resonant mode in superconducting Ca(Fe1-xCox)AsF single crystals
DOI: 10.5291/ill-data.4-04-505
title: Evolution of the Dy3+ magnetic anisotropy in Dy3B2C3O12 garnets
DOI: 10.5291/ill-data.4-04-507
title: Hyperfine coupling as a probe of the unconventional nature of the Nd2Zr2O7 pyrochlore magnet
DOI: 10.25500/edata.bham.00000698
title: Data Supporting HEavy Precipitation forecast Post-processing over India (HEPPI)
DOI: 10.5291/ill-data.4-05-847
title: Exploring Spin Correlations in a Frustrated Quantum Magnet by Neutron Spin-Echo
DOI: 10.5291/ill-data.5-23-760
title: Lithium cation distribution and mobility in lithium inserted Li1+xNbWO6  (0 < x < 3) as promising host for lithium storage applications
DOI: 10.5291/ill-data.5-31-2837
title: Doping induced change of magnetic structure in BaFe2Se3
DOI: 10.5291/ill-data.5-31-2879
title: Magnetic and non-magnetic phases in S=1/2 kagome compounds of the atacamite family
DOI: 10.5291/ill-data.5-51-565
title: Polarized neutron diffraction study on the field-induce magnetizationin FeSe
DOI: 10.5291/ill-data.5-54-352
title: Domain wall dynamics in arrays of Permalloy rings
DOI: 10.5291/ill-data.5-54-354
title: Magneto-elastic coupling in Co2FeSi /BaTiO3 heterostructures
DOI: 10.5291/ill-data.5-54-356
title: Magnetic correlations and spin glass like behaviour in Cr2Te3 thin films
DOI: 10.5291/ill-data.5-54-347
title: Determination of the magnetic structure in piezomagnetic Mn3SnN thin films using neutron diffraction
DOI: 10.5291/ill-data.5-54-349
title: Magnetic correlations in Fe-oxide nanoflowers for cancer treatment by hyperthermia
DOI: 10.5291/ill-data.5-54-309
title: Accessing the twisted states during the thermal hysteresis of GdCo/Co multilayers
DOI: 10.5291/ill-data.6-03-456
title: Investigating the Liquid Structure of Ionic Liquids containing Basic Anions used in Gas Capture Applications
DOI: 10.5291/ill-data.6-05-1015
title: Pressure-driven change to the Mg and Al coordination environments in silicate glass
DOI: 10.5291/ill-data.6-05-1033
title: Investigating how amorphous phase separation and heat treatment impact nucleation and crystallisation in apatite glass-ceramics using SANS
DOI: 10.15468/vwxsyy
title: A new Scleromystax species (Siluriformes: Callichthyidae) from coastal rivers of Southern Brazil

description: This dataset contains the digitized treatments in Plazi based on the original journal article Britto, Marcelo R., Reis, Roberto E. (2005): A new Scleromystax species (Siluriformes: Callichthyidae) from coastal rivers of Southern Brazil. Neotropical Ichthyology 3 (4): 481-488, DOI: 10.1590/S1679-62252005000400005, URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252005000400005&lng=en&tlng=en
DOI: 10.5291/ill-data.6-07-70
title: Permeability of Silica Porous Liquids thanks to coupled in situ SANS experiments and N2 sorption isotherm
DOI: 10.15468/suecva
title: Caractères diagnostiques morpho-anatomiques d’Oxyloma sarsii (Esmark 1886) (Mollusca Gastropoda Succineidae) et nouvelles données dans le nord-est de la France (Alsace et Franche-Comté)

description: This dataset contains the digitized treatments in Plazi based on the original journal article Bichain, Jean-Michel, Ryelandt, Julien, Umbrecht, Kevin (2021): Caractères diagnostiques morpho-anatomiques d’Oxyloma sarsii (Esmark 1886) (Mollusca Gastropoda Succineidae) et nouvelles données dans le nord-est de la France (Alsace et Franche-Comté). Zoosystema 43 (19): 365-376, DOI: 10.5252/zoosystema2021v43a19