cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25549/examiner-c44-17782
title: Society -- Hollywood Bowl, 1951

description: 21 images. Society -- Hollywood Bowl, 26 July 1951. Mrs. Albert Leland; Mrs. Edward Currier; Mr. and Mrs. Alfred Wallenstein; Miss Ana Mahler; John Arensona; Madamme Alma Mahler Werfel; Mr. and Mrs. Norman Herman; Mrs. Walter Jackson; Madame Yeatman Griffith; Mr. and Mrs. Richard Rifenbark; Mr. and Mrs. Neil Patrie; Mr. and Mrs. E. De Baillets; Karl Lindt; Doctor Bruno Walter; William C. Hartshorn; Gregor Piatigorsky; Lieutenant Governor and Mrs. Goodwin Knight; Mr. and Mrs. Robert V. New.
DOI: 10.15468/dl.agp7w8
title: Occurrence Download

description: A dataset containing 2991 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Echinops exaltatus Schrad.)"
 ]
}

 The dataset includes 2991 records from 160 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017272-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25402/nnm.24565201
title: Photothermal performance of a novel carbon dot and its conjugate with disulfiram for prostate cancer PC3 cell therapy - supplementary data

description: <b>Aim: </b>To develop and employ a copper, sulfur, nitrogen–carbon quantum dot (C,S,N-CQD) multifunctionalplatform for synergistic cancer therapy, combining chemotherapy and photothermal treatment with<i>in vitro </i>cancer cell imaging. <b>Materials & methods: </b>Cu,S,N-CQDs were synthesized hydrothermally,loaded with disulfiram (DSF), and characterized through UV-Vis spectrophotometry, photoluminescence,Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy, dynamic lightscattering, x-ray diffraction and EDAX. <b>Results: </b>Cu,S,N-CQD exhibited 5.5% absolute fluorescencequantum yield, 46.0% photothermal conversion efficiency and excellent stability. The release of DSFloadedCu,S,N-CQD, photothermal performance, and IC50 on PC3 prostate cancer cells, were evaluated. Theimpact of cellular glutathione on nanocarrier performance was investigated. <b>Conclusion: </b>Cu,S,N-CQD asa photothermal agent and DSF carrier showed synergy (combination index: 0.71) between chemotherapyand photothermal therapy. The nanocarrier simultaneously employed for <i>in vitro </i>cancer cell imaging dueto its unique fluorescence properties.<b>Plain language summary: </b>Nanometer-scale particles can be used to treat and detect cancer in many ways.A type of nanoparticle was designed to attack cancer in two different ways. These nanoparticles – copper,sulfur, nitrogen–carbon quantum dots (C,S,N–CQDs) – were designed to both deliver a chemotherapydrug to cancer cells and act as a photothermal agent. This means that when light of a particular energyis shone on these particles, they heat up and can kill cancer cells. These C,S,N–CQDs loaded with thechemotherapy drug disulfiram were then tested on the prostate cancer cell line PC3. When a laser wasshone on these particles and they became excited, they reduced cancer cell viability both by releasing thedrug and heating up and killing the surrounding cells. These Cu,S,N-CQDs are also fluorescent, meaningthey can be used to image cancer cells in tests like these.
DOI: 10.25402/nnm.24565201.v1
title: Photothermal performance of a novel carbon dot and its conjugate with disulfiram for prostate cancer PC3 cell therapy - supplementary data

description: <b>Aim: </b>To develop and employ a copper, sulfur, nitrogen–carbon quantum dot (C,S,N-CQD) multifunctionalplatform for synergistic cancer therapy, combining chemotherapy and photothermal treatment with<i>in vitro </i>cancer cell imaging. <b>Materials & methods: </b>Cu,S,N-CQDs were synthesized hydrothermally,loaded with disulfiram (DSF), and characterized through UV-Vis spectrophotometry, photoluminescence,Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy, dynamic lightscattering, x-ray diffraction and EDAX. <b>Results: </b>Cu,S,N-CQD exhibited 5.5% absolute fluorescencequantum yield, 46.0% photothermal conversion efficiency and excellent stability. The release of DSFloadedCu,S,N-CQD, photothermal performance, and IC50 on PC3 prostate cancer cells, were evaluated. Theimpact of cellular glutathione on nanocarrier performance was investigated. <b>Conclusion: </b>Cu,S,N-CQD asa photothermal agent and DSF carrier showed synergy (combination index: 0.71) between chemotherapyand photothermal therapy. The nanocarrier simultaneously employed for <i>in vitro </i>cancer cell imaging dueto its unique fluorescence properties.<b>Plain language summary: </b>Nanometer-scale particles can be used to treat and detect cancer in many ways.A type of nanoparticle was designed to attack cancer in two different ways. These nanoparticles – copper,sulfur, nitrogen–carbon quantum dots (C,S,N–CQDs) – were designed to both deliver a chemotherapydrug to cancer cells and act as a photothermal agent. This means that when light of a particular energyis shone on these particles, they heat up and can kill cancer cells. These C,S,N–CQDs loaded with thechemotherapy drug disulfiram were then tested on the prostate cancer cell line PC3. When a laser wasshone on these particles and they became excited, they reduced cancer cell viability both by releasing thedrug and heating up and killing the surrounding cells. These Cu,S,N-CQDs are also fluorescent, meaningthey can be used to image cancer cells in tests like these.
DOI: 10.25402/nnm.24565258
title: Carbon dots and composite materials with excellent performances in cancer-targeted bioimaging and killing: a review - supplementary data

description: Carbon dots (CDs) are nanomaterials with excellent properties, including good biocompatibility, smallsize, ideal photoluminescence and surface modification, and are becoming one of the most attractivenanomaterials for the imaging, detection and treatment of tumors. Based on these advantages, CDscan be combined other materials to obtain composite particles with improved, even new, performance,mainly in photothermal and photodynamic therapies. This paper reviews the research progress of CDs andtheir composites in targeted tumor imaging, detection, diagnosis, drug delivery and tumor killing. It alsodiscusses and proposes the challenges and perspectives of their future applications in these fields. Thisreview provides ideas for future applications of novel CD-based materials in the diagnosis and treatmentof cancer.
DOI: 10.25402/nnm.24565258.v1
title: Carbon dots and composite materials with excellent performances in cancer-targeted bioimaging and killing: a review - supplementary data

description: Carbon dots (CDs) are nanomaterials with excellent properties, including good biocompatibility, smallsize, ideal photoluminescence and surface modification, and are becoming one of the most attractivenanomaterials for the imaging, detection and treatment of tumors. Based on these advantages, CDscan be combined other materials to obtain composite particles with improved, even new, performance,mainly in photothermal and photodynamic therapies. This paper reviews the research progress of CDs andtheir composites in targeted tumor imaging, detection, diagnosis, drug delivery and tumor killing. It alsodiscusses and proposes the challenges and perspectives of their future applications in these fields. Thisreview provides ideas for future applications of novel CD-based materials in the diagnosis and treatmentof cancer.
DOI: 10.25402/nnm.24592416
title: Efficacy and safety of nab-paclitaxel in metastatic gastric cancer: a meta-analysis - supplementary files

description: <b>Background: </b>Nab-paclitaxel is formulated to address several limitations of paclitaxel. <b>Methods: </b>A systematic review was done of several databases and a meta-analysis with a random-effects model was conducted to assess the efficacy and safety of nab-paclitaxel in metastatic gastric cancer (MGC). <b>Results: </b>Included studies revealed that nab-paclitaxel provides a 30.4% overall response rate and 65.7% disease control rate in MGC patients. The overall survival was 9.65 months and progression-free survival was 4.48 months, associated with the treatment line and regimen. The highest incidence of grade 3 and higher treatment-related adverse events was for neutropenia (29.9%). <b>Conclusion: </b>Nab-paclitaxel provides better disease response and longer survival with manageable side effects in MGC compared with paclitaxel.
DOI: 10.25402/nnm.24592416.v1
title: Efficacy and safety of nab-paclitaxel in metastatic gastric cancer: a meta-analysis - supplementary files

description: <b>Background: </b>Nab-paclitaxel is formulated to address several limitations of paclitaxel. <b>Methods: </b>A systematic review was done of several databases and a meta-analysis with a random-effects model was conducted to assess the efficacy and safety of nab-paclitaxel in metastatic gastric cancer (MGC). <b>Results: </b>Included studies revealed that nab-paclitaxel provides a 30.4% overall response rate and 65.7% disease control rate in MGC patients. The overall survival was 9.65 months and progression-free survival was 4.48 months, associated with the treatment line and regimen. The highest incidence of grade 3 and higher treatment-related adverse events was for neutropenia (29.9%). <b>Conclusion: </b>Nab-paclitaxel provides better disease response and longer survival with manageable side effects in MGC compared with paclitaxel.
DOI: 10.25549/examiner-c44-73320
title: Murder suspect, 1957

description: 2 images. Murder suspect, 6 December 1957. Cecil Leighty.
DOI: 10.25402/nnm.24592452
title: Silver-cored <i>Ziziphus spina-christi</i> extract-loaded antimicrobial nanosuspension: overcoming multidrug resistance supplementary materials

description: <b>Aims: </b>To synthesize a silver-cored nanosuspension utilizing <i>Ziziphus spina-christi </i>fresh-leaf extract and evaluate their antimicrobial activity against multidrug-resistant pathogenic microbes. <b>Materials and Methods: </b>The prepared nanosuspension was analyzed by spectro-analytical techniques and tested for antimicrobial activity and resistance to biofilm formation. The leaf extract and nanosuspension were tested separately and together as a mixture. <b>Results: </b>Constituent nanoparticles were average-sized (<b>∼</b>34 nm) and were active against both Gram-positive and Gram-negative microbes and yeast. <i>Candida albicans </i>showed a 24.50 <b>± </b>1.50 mm inhibition zone, followed by <i>Escherichia coli </i>and <i>Staphylococcus aureus</i>. Increased bioactivity with the highest multifold increments, 150%, for erythromycin against all tested microbes was observed. Carbenicillin and trimethoprim showed 166%- and 300%-fold increments for antimicrobial activity against <i>Pseudomonas aeruginosa</i>, respectively. <b>Conclusion: </b>The nanosuspension exhibited strong potential as an antimicrobial agent and overcame multidrug resistance.<b>Plain language summary: </b><i>Ziziphus spina-christi </i>leaf extract-coated silver nanoparticles were synthesized using an environment-friendly method, and the preparation was effective against <i>Escherichia coli</i>, <i>Staphylococcus aureus </i>and <i>Candida albicans</i>. The prepared formulation showed increased antimicrobial activity at a 150–300% increase compared with leaf extract-only activity. The prepared suspension was also active against <i>Pseudomonas aeruginosa</i>, the multidrug-resistant microbe, and has the potential to treat drug-resistant microbial infections.
DOI: 10.25402/nnm.24592452.v1
title: Silver-cored <i>Ziziphus spina-christi</i> extract-loaded antimicrobial nanosuspension: overcoming multidrug resistance supplementary materials

description: <b>Aims: </b>To synthesize a silver-cored nanosuspension utilizing <i>Ziziphus spina-christi </i>fresh-leaf extract and evaluate their antimicrobial activity against multidrug-resistant pathogenic microbes. <b>Materials and Methods: </b>The prepared nanosuspension was analyzed by spectro-analytical techniques and tested for antimicrobial activity and resistance to biofilm formation. The leaf extract and nanosuspension were tested separately and together as a mixture. <b>Results: </b>Constituent nanoparticles were average-sized (<b>∼</b>34 nm) and were active against both Gram-positive and Gram-negative microbes and yeast. <i>Candida albicans </i>showed a 24.50 <b>± </b>1.50 mm inhibition zone, followed by <i>Escherichia coli </i>and <i>Staphylococcus aureus</i>. Increased bioactivity with the highest multifold increments, 150%, for erythromycin against all tested microbes was observed. Carbenicillin and trimethoprim showed 166%- and 300%-fold increments for antimicrobial activity against <i>Pseudomonas aeruginosa</i>, respectively. <b>Conclusion: </b>The nanosuspension exhibited strong potential as an antimicrobial agent and overcame multidrug resistance.<b>Plain language summary: </b><i>Ziziphus spina-christi </i>leaf extract-coated silver nanoparticles were synthesized using an environment-friendly method, and the preparation was effective against <i>Escherichia coli</i>, <i>Staphylococcus aureus </i>and <i>Candida albicans</i>. The prepared formulation showed increased antimicrobial activity at a 150–300% increase compared with leaf extract-only activity. The prepared suspension was also active against <i>Pseudomonas aeruginosa</i>, the multidrug-resistant microbe, and has the potential to treat drug-resistant microbial infections.
DOI: 10.25402/nnm.24611493
title: Bimatoprost-loaded lipidic nanoformulation development using quality by design: liposomes versus solid lipid nanoparticles in intraocular pressure reduction - supplementary materials

description: <b>Background: </b>Bimatoprost is a drug used to lower intraocular pressure in the treatment of glaucoma. Conventional eye drops have the limitations of repeated dosing, drug loss due to tear outflow and hence poor availability for action. <b>Materials & methods: </b>Using a systematic quality by design approach, liposomes and solid lipid nanoparticles were formulated and further encapsulated in thermo-sensitive <i>in situ </i>hydrogel. <b>Results & conclusion: </b>Optimized liposomes had 87.04% encapsulation efficiency and 306.78 nm mean particle size, while solid lipid nanoparticles had 90.51% and 304.21 nm. Bimatoprost liposomes had controlled zero-order drug kinetics and no initial burst release, making them better than solid lipid nanoparticles. Bimatoprost-loaded liposomes in thermo-sensitive hydrogel decreased intraocular pressure for 18 h.
DOI: 10.25402/nnm.24611493.v1
title: Bimatoprost-loaded lipidic nanoformulation development using quality by design: liposomes versus solid lipid nanoparticles in intraocular pressure reduction - supplementary materials

description: <b>Background: </b>Bimatoprost is a drug used to lower intraocular pressure in the treatment of glaucoma. Conventional eye drops have the limitations of repeated dosing, drug loss due to tear outflow and hence poor availability for action. <b>Materials & methods: </b>Using a systematic quality by design approach, liposomes and solid lipid nanoparticles were formulated and further encapsulated in thermo-sensitive <i>in situ </i>hydrogel. <b>Results & conclusion: </b>Optimized liposomes had 87.04% encapsulation efficiency and 306.78 nm mean particle size, while solid lipid nanoparticles had 90.51% and 304.21 nm. Bimatoprost liposomes had controlled zero-order drug kinetics and no initial burst release, making them better than solid lipid nanoparticles. Bimatoprost-loaded liposomes in thermo-sensitive hydrogel decreased intraocular pressure for 18 h.
DOI: 10.25549/examiner-c44-52533
title: Scout mother's camp out (Altadena), 1958

description: 10 images. Scout mother's camp out (Altadena), 27 June 1958. Mrs. Richard Bailey; Mrs. Paul East; Mrs. D.J. Crumb; Mrs. Robert Bernhard; Mrs. Henry W. Snyder; Mrs. Frank J. Ziol; Mrs. Kenneth Coombs; Mrs. Maurice Pitzer; Mrs. John Kepler; Mrs. Don Lewis; Mrs. Clyde Martin; Mrs. Lou Burstein; Mrs. Thomas Dublin; Mrs. Lee A. Berry; Mrs. Morris Outwater; Mrs. Harold Beveridge; Mrs. George Becker; Mrs. Robert Kahn; Mrs. Joe Barlow.; Caption slip reads: "Photographer: Swaim. Date: 1958-06-27. Reporter: Swaim. Assignment: Scout mother's camp out. Camp Huntington, Altadena. 12: Mrs. Lou Berstein, left, past pres., and Mrs. Thomas Dublin, 1st vice-pres. arriving for 17th annual campout [sic] of Federation of Mothers' Auxiliaries, San Gabriel Council, Boy Scouts. 4: L to R, Mrs. Ancel A. Horn, past pres., Mrs. Thomas Dublin 1st VP, and Mrs. Lee A. Berry, president, starting cookout for their campout [sic]. 9: Mrs. Morris Outwater, Mrs. Harold Beveridge, Mrs. George Becker and Mrs. Robert Kahn, cooking steaks, corn, etc. 10: Mrs. Joe Barlow munching on ear of corn. 19: Mrs. Richard Bailey, left, and Mrs. Paul East cooking steaks. 25/26: 'Purple people eaters' getting costume for skit at campout. L to R, Mrs. D.J. Crumb (sitting on log), Mrs. Robert Bernhard (peeking out of back of costume), Mrs. Henry W. Snyder, having custome [sic] arranged by Mrs. Frank J. Ziol. All are from Troop 4, Pasadena. 20: L to R, Mrs. Kenneth Coombs, Mrs. Maurice Pitzer, and Mrs. John Kepler making salad. 5: Mrs. Don Lewis (top) and Mrs. Clyde Martin (under), improvising table as a double bunk to get off ground away from animals, snakes, etc. 6: Same Mrs. Don Lewis and Mrs. Clyde Martin, add (l to r) Mrs. Paul East, Mrs. Herman Luebke, on horse, and Mrs. Richard Bailey".
DOI: 10.25402/nnm.24611847
title: Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain - supplementary materials

description: <b>Background: </b>Glioblastoma is the most common and lethal brain cancer. New treatments are needed. However, the presence of the blood–brain barrier is limiting the development of new treatments directed toward the brain, as it restricts the access and distribution of drugs to the CNS. <b>Materials & methods: </b>In this work, two different nanoparticles (i.e., mesoporous silica nanoparticles and magnetic mesoporous silica nanoparticles) loaded with ponatinib were prepared. <b>Results & conclusion: </b>Both particles were characterized and tested <i>in vitro </i>and <i>in vivo</i>, proving that they are not toxic for blood–brain barrier cells and they increase the amount of drug reaching the brain when administered intranasally in comparison with the results obtained for the free drug.<b>Plain language summary: </b>This article presents a couple of promising nanoparticles for the treatment of brain cancer. This research is interesting because the brain and spinal cord are protected by a membrane that prevents toxic substances from reaching them but also hinders the access of drugs.One type of particle has a magnet in its core, so it can be driven with another externalmagnet until it reaches target; the other type does not have a magnet but has a small size, which would allow it to cross the membrane mentioned above. These particles have been proven to be able to kill cancer cells.
DOI: 10.25402/nnm.24611847.v1
title: Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain - supplementary materials

description: <b>Background: </b>Glioblastoma is the most common and lethal brain cancer. New treatments are needed. However, the presence of the blood–brain barrier is limiting the development of new treatments directed toward the brain, as it restricts the access and distribution of drugs to the CNS. <b>Materials & methods: </b>In this work, two different nanoparticles (i.e., mesoporous silica nanoparticles and magnetic mesoporous silica nanoparticles) loaded with ponatinib were prepared. <b>Results & conclusion: </b>Both particles were characterized and tested <i>in vitro </i>and <i>in vivo</i>, proving that they are not toxic for blood–brain barrier cells and they increase the amount of drug reaching the brain when administered intranasally in comparison with the results obtained for the free drug.<b>Plain language summary: </b>This article presents a couple of promising nanoparticles for the treatment of brain cancer. This research is interesting because the brain and spinal cord are protected by a membrane that prevents toxic substances from reaching them but also hinders the access of drugs.One type of particle has a magnet in its core, so it can be driven with another externalmagnet until it reaches target; the other type does not have a magnet but has a small size, which would allow it to cross the membrane mentioned above. These particles have been proven to be able to kill cancer cells.
DOI: 10.25402/nnm.24611913
title: An update review of smart nanotherapeutics and liver cancer: opportunities and challenges - supplementary tables

description: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, typically diagnosed in advanced stages. Chemotherapy is necessary for treating advanced liver cancer; however, several challenges affect its effectiveness. These challenges include low specificity, high dosage requirements, high systemic toxicity and severe side effects, which significantly limit the efficacy of chemotherapy. These limitations can hinder the treatment of HCC. This review focuses on the prevalence of HCC, different types of liver cancer and the staging of the disease, along with available treatment methods. Additionally, explores recent and relevant studies on smart drug- and gene-delivery systems specifically designed for HCC. These systems include targeted endogenous and exogenous stimuli-responsive platforms.<b>Plain language summary: </b>Liver cancer is the third leading cause of cancer deaths in the world that is usually diagnosed in the last stages. Chemotherapy is commonly used to treat advanced liver cancer, but it faces several challenges that reduce its effectiveness. These challenges include low specificity (not targeting cancer cells specifically), high dosage requirements and side effects that can affect anywhere in the body. As a result, the efficacy of chemotherapy is significantly limited, making it difficult to treat liver cancer. This review discusses the prevalence of liver cancer, different types of liver cancer and how the disease is staged. It also explores various treatment methods available for liver cancer. Furthermore, the article explores recent and relevant studies on smart drug- and gene-delivery systems that are specifically designed to target liver cancer. These systems include platforms that respond to targeted and internal or external stimuli. They aim to improve the effectiveness of treatment for liver cancer.