cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2k35zh4
title: BindingDB Entry 11048: Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases

description: Small molecule binding data for protein Kallikrein-1, Kallikrein-6, and Plasminogen, Uniprot P00747, P06870, and Q92876
DOI: 10.7270/q2fb56ss
title: BindingDB Entry 11049: Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease

description: Small molecule binding data for protein GTPase KRas [G12D,Q61H], Uniprot P01116
DOI: 10.7270/q29k4g2g
title: BindingDB Entry 11050: Tetrahydroisoquinoline derivatives, preparation process and use thereof

description: Small molecule binding data for protein Coagulation factor VII, Coagulation factor X, and Coagulation factor XI, Uniprot P00742, P03951, and P08709
DOI: 10.7270/q25t3qbr
title: BindingDB Entry 11051: Heterocyclic compounds and uses thereof

description: Small molecule binding data for protein Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Uniprot O00329, P42336, P42338, and P48736
DOI: 10.7270/q2222zns
title: BindingDB Entry 11052: STK19 inhibitors for treatment of cancer

description: Small molecule binding data for protein Serine/threonine-protein kinase 19, Uniprot P0C6U8
DOI: 10.7270/q2xd15h9
title: BindingDB Entry 11053: Substituted piperazines as selective HDAC1,2 inhibitors

description: Small molecule binding data for protein Cytochrome P450 1A2, Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3, and Potassium voltage-gated channel subfamily H member 2, Uniprot O15379, P05177, Q12809, Q13547, and Q92769
DOI: 10.7270/q2sn0dt1
title: BindingDB Entry 11054: Quinoline compounds as IRAK inhibitors and uses thereof

description: Small molecule binding data for protein Interleukin-1 receptor-associated kinase 1 and Interleukin-1 receptor-associated kinase 4, Uniprot P51617 and Q9NWZ3
DOI: 10.7270/q2nv9p35
title: BindingDB Entry 11055: Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer

description: Small molecule binding data for protein Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, and Vascular endothelial growth factor receptor 2, Uniprot P11362, P21802, P22455, P22607, and P35968
DOI: 10.7270/q2j38xd6
title: BindingDB Entry 11056: BTK inhibitor compounds

description: Small molecule binding data for protein Epidermal growth factor receptor and Tyrosine-protein kinase BTK, Uniprot P00533 and Q06187
DOI: 10.7270/q2db85pv
title: BindingDB Entry 11057: IRAK degraders and uses thereof

description: Small molecule binding data for protein Interleukin-1 receptor-associated kinase 1 and Interleukin-1 receptor-associated kinase 4, Uniprot P51617 and Q9NWZ3
DOI: 10.7270/q28k7dxp
title: BindingDB Entry 11058: Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors

description: Small molecule binding data for protein Catenin beta-1/B-cell CLL/lymphoma 9 protein, Uniprot O00512 and P35222
DOI: 10.7270/q24t6p7t
title: BindingDB Entry 11059: Compounds for the treatment of kinase-dependent disorders

description: Small molecule binding data for protein Hepatocyte growth factor receptor MET Isoform 2 [974-1390,A1209G,V1290L], Tyrosine-protein kinase Mer [557-882,H628Q,R794A], and Tyrosine-protein kinase receptor UFO [473-894,Q764R], Uniprot P08581, P30530, and Q12866
DOI: 10.7270/q2154mw8
title: BindingDB Entry 11060: Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors

description: Small molecule binding data for protein Cyclin-H/Cyclin-dependent kinase 7, Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L], GTPase NRas, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, Platelet-derived growth factor receptor beta, Proto-oncogene tyrosine-protein kinase receptor Ret, Receptor-type tyrosine-protein kinase FLT3 [564-710,762-958], Receptor-type tyrosine-protein kinase FLT3 [D835H], Receptor-type tyrosine-protein kinase FLT3 [D835V], Receptor-type tyrosine-protein kinase FLT3 [D835Y], Receptor-type tyrosine-protein kinase FLT3 [K633Q], Receptor-type tyrosine-protein kinase FLT3 [N841I], Receptor-type tyrosine-protein kinase FLT3 [R834Q], SRSF protein kinase 1, Tyrosine-protein kinase Blk, and Tyrosine-protein kinase Lck, Uniprot P01111, P06239, P07949, P09619, P36888, P50613, P51451, P51617, P51946, Q96SB4, and Q9NWZ3
DOI: 10.7270/q2wd44ft
title: BindingDB Entry 11061: Pyrazolopyrimidine compounds and uses thereof

description: Small molecule binding data for protein Mitogen-activated protein kinase kinase kinase kinase 1, Uniprot Q92918
DOI: 10.7270/q2rn3cq3
title: BindingDB Entry 11062: Substituted piperidines as BTK inhibitors

description: Small molecule binding data for protein Tyrosine-protein kinase BTK and Tyrosine-protein kinase BTK [C481S], Uniprot Q06187
DOI: 10.7270/q2mw2n0s
title: BindingDB Entry 11063: Amide compound having bet proteolysis-inducing action and medicinal application thereof

description: Small molecule binding data for protein Bromodomain-containing protein 4, Uniprot O60885
DOI: 10.7270/q2h41w8c
title: BindingDB Entry 11064: Therapeutic compounds and methods of use thereof

description: Small molecule binding data for protein Protein cereblon, Uniprot Q96SW2
DOI: 10.7270/q2cc14j1
title: BindingDB Entry 11065: Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors

description: Small molecule binding data for protein Protein arginine N-methyltransferase 5, Uniprot O14744
DOI: 10.7270/q27p937g
title: BindingDB Entry 11066: Synthesis of peptide borate ester compound and use thereof

description: Small molecule binding data for protein Proteasome subunit alpha type-6, Uniprot P60900
DOI: 10.7270/q23x8bhr
title: BindingDB Entry 11067: Phenothiazine derivatives and uses thereof

description: Small molecule binding data for protein Calmodulin-1, Uniprot P0DP23
DOI: 10.7270/q2057kts
title: BindingDB Entry 11068: Sting modulator compounds, and methods of making and using

description: Small molecule binding data for protein Stimulator of interferon genes protein, Uniprot Q86WV6
DOI: 10.7270/q2vd73bw
title: BindingDB Entry 11069: Compositions and methods for treating CNS disorders

description: Small molecule binding data for protein Gamma-aminobutyric acid receptor subunit gamma-1, Uniprot P23574
DOI: 10.7270/q2qn6bnm
title: BindingDB Entry 11070: INDOLE DERIVATIVES AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 2A, Uniprot P28223
DOI: 10.7270/q2kw5kwf
title: BindingDB Entry 11071: SEROTONIN 5-HT2A, 5-HT2B, AND 5-HT2C RECEPTOR INVERSE AGONISTS

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, BDBP50000595, and Histamine H1 receptor, Uniprot P14598, P28223, P28335, P35367, and P41595
DOI: 10.7270/q2g44v5f
title: BindingDB Entry 11072: MAP4K1 INHIBITORS

description: Small molecule binding data for protein Mitogen-activated protein kinase kinase kinase kinase 1, Uniprot Q92918
DOI: 10.7270/q2bg2stk
title: BindingDB Entry 11073: Neprilysin inhibitors

description: Small molecule binding data for protein Neprilysin/Angiotensin-converting enzyme, Uniprot P08473 and P12821
DOI: 10.7270/q26q223n
title: BindingDB Entry 11074: LSD1 inhibitors and medical uses thereof

description: Small molecule binding data for protein Lysine-specific histone demethylase 1A, Uniprot O60341
DOI: 10.7270/q22z19dc
title: BindingDB Entry 11075: Heterocyclic compounds and uses thereof

description: Small molecule binding data for protein Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, and Serine/threonine-protein kinase mTOR, Uniprot O00329, P42336, P42338, P42345, and P48736
DOI: 10.7270/q2z60sx0
title: BindingDB Entry 11076: Kinase inhibitor compounds and compositions and methods of use

description: Small molecule binding data for protein Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Uniprot Q13627
DOI: 10.7270/q2tf0262
title: BindingDB Entry 11077: Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1

description: Small molecule binding data for protein Aromatase, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, and Steroid 17-alpha-hydroxylase/17,20 lyase, Uniprot P05093, P05177, P08684, P10635, P11511, P11712, and P33261
DOI: 10.7270/q2pn99gs
title: BindingDB Entry 11078: Therapeutic compounds and methods of use thereof

description: Small molecule binding data for protein E3 ubiquitin-protein ligase Mdm2, Uniprot Q00987
DOI: 10.7270/q2jw8jr2
title: BindingDB Entry 11079: Isoquinolin-3-yl carboxamides and preparation and use thereof

description: Small molecule binding data for protein Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Uniprot Q13627
DOI: 10.7270/q2f76hdx
title: BindingDB Entry 11080: Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same

description: Small molecule binding data for protein Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Uniprot Q13822
DOI: 10.7270/q29g5rp6
title: BindingDB Entry 11081: HPK1 antagonists and uses thereof

description: Small molecule binding data for protein Mitogen-activated protein kinase kinase kinase kinase 1, Uniprot Q92918
DOI: 10.7270/q25q50zv
title: BindingDB Entry 11082: Transglutaminase 2 (TG2) inhibitors

description: Small molecule binding data for protein Mitogen-activated protein kinase kinase kinase kinase 1, Uniprot Q92918
DOI: 10.7270/q21z4880
title: BindingDB Entry 11083: Heterocyclic compounds as RET kinase inhibitors

description: Small molecule binding data for protein Proto-oncogene tyrosine-protein kinase receptor Ret, Proto-oncogene tyrosine-protein kinase receptor Ret [V804M], and Vascular endothelial growth factor receptor 2, Uniprot P07949 and P35968
DOI: 10.7270/q2x63rsm
title: BindingDB Entry 11084: Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof

description: Small molecule binding data for protein Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2, Uniprot P00533 and P04626
DOI: 10.7270/q2sf310s
title: BindingDB Entry 11085: Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections

description: Small molecule binding data for protein Solute carrier family 22 member 2, Uniprot O15244
DOI: 10.7270/q2np2882
title: BindingDB Entry 11086: Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

description: Small molecule binding data for protein Beta-secretase 1, Beta-secretase 2, and Cathepsin D, Uniprot P07339, P56817, and Q9Y5Z0
DOI: 10.7270/q2j10718
title: BindingDB Entry 11087: Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers

description: Small molecule binding data for protein RAF proto-oncogene serine/threonine-protein kinase and Serine/threonine-protein kinase B-raf [V600E], Uniprot P04049 and P15056
DOI: 10.7270/q2d79g90
title: BindingDB Entry 50014739: Discovery of New Potent Positive Allosteric Modulators of Dopamine D

description: Small molecule binding data for protein D(2) dopamine receptor, Uniprot P14416
DOI: 10.7270/q28g8qk8
title: BindingDB Entry 50014740: Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide-deoxynojirimycin Conjugates.

description: Small molecule binding data for protein Alpha-mannosidase, Uniprot C0HJB3
DOI: 10.7270/q24q7zvj
title: BindingDB Entry 50014741: Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

description: Small molecule binding data for protein Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphatidylinositol 4-kinase alpha, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, and Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, Uniprot O00329, O00443, O00750, O75747, P42336, P42356, P48736, Q8NEB9, Q9JHG7, and Q9UBF8
DOI: 10.7270/q20z774m
title: BindingDB Entry 50014742: Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel.

description: Small molecule binding data for protein Cytochrome P450 3A4, Uniprot P08684
DOI: 10.7270/q2w66qms
title: BindingDB Entry 50014743: Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists.

description: Small molecule binding data for protein Orexin receptor type 2 and Orexin/Hypocretin receptor type 1, Uniprot O43613 and O43614
DOI: 10.7270/q2rf5zw2
title: BindingDB Entry 50014744: Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.

description: Small molecule binding data for protein Bromodomain-containing protein 4, CREB-binding protein, and Histone acetyltransferase p300, Uniprot O60885, Q09472, and Q92793
DOI: 10.7270/q2ms3xmh
title: BindingDB Entry 50014745: Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.

description: Small molecule binding data for protein Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, and von Hippel-Lindau disease tumor suppressor, Uniprot P40337, P51617, and Q9NWZ3
DOI: 10.7270/q2h135wg
title: BindingDB Entry 50014747: Structural Insights into Notum Covalent Inhibition.

description: Small molecule binding data for protein Palmitoleoyl-protein carboxylesterase NOTUM, Uniprot Q6P988
DOI: 10.7270/q2c82f55
title: BindingDB Entry 50014748: Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.

description: Small molecule binding data for protein Aldehyde oxidase, Uniprot Q06278
DOI: 10.7270/q27h1pff
title: BindingDB Entry 50014749: Identification of unprecedented ATP-competitive choline kinase inhibitors.

description: Small molecule binding data for protein Choline kinase alpha and Choline/ethanolamine kinase, Uniprot P35790 and Q9Y259
DOI: 10.7270/q23r0xqq
title: BindingDB Entry 50014750: 4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors.

description: Small molecule binding data for protein CREB-binding protein, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase KAT6B, Histone acetyltransferase KAT7, and Histone acetyltransferase p300, Uniprot O95251, Q09472, Q8WYB5, Q92793, Q92830, Q92831, and Q92993
DOI: 10.7270/q20005xs
title: BindingDB Entry 50014751: Enhancing the Pharmacokinetic Profile of Interleukin 2 through Site-Specific Conjugation to a Selective Small-Molecule Transthyretin Ligand.

description: Small molecule binding data for protein Interleukin-2 and Transthyretin, Uniprot P02766 and P60568
DOI: 10.7270/q2v69pfz
title: BindingDB Entry 50014752: JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

description: Small molecule binding data for protein Adenosine receptor A1, Beta-secretase 1, Beta-secretase 2, Cathepsin D, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2D6, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Potassium voltage-gated channel subfamily H member 2, Sodium-dependent serotonin transporter, and Substance-K receptor, Uniprot P05177, P07339, P08172, P10635, P11229, P21452, P30542, P31645, P33261, P56817, Q12809, Q9JL18, and Q9Y5Z0
DOI: 10.7270/q2qj7n4z
title: BindingDB Entry 50014753: Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study.

description: Small molecule binding data for protein Acetylcholinesterase and Cholinesterase, Uniprot P06276 and P22303
DOI: 10.7270/q2ks6wd7
title: BindingDB Entry 50014754: Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.

description: Small molecule binding data for protein Bromodomain-containing protein 4 and Myc proto-oncogene protein, Uniprot O60885 and P01106
DOI: 10.7270/q2g164p6
title: BindingDB Entry 50014757: Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.

description: Small molecule binding data for protein Epidermal growth factor receptor, Uniprot P00533
DOI: 10.7270/q2b85d0b
title: BindingDB Entry 50014760: Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.

description: Small molecule binding data for protein Proto-oncogene tyrosine-protein kinase Src, Uniprot P12931
DOI: 10.7270/q26h4n8m
title: BindingDB Entry 50014762: Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.

description: Small molecule binding data for protein Bromodomain testis-specific protein and Bromodomain-containing protein 4, Uniprot O60885 and Q58F21
DOI: 10.7270/q22r3whf
title: BindingDB Entry 50014763: Discovery of structurally distinct tricyclic M

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M4, Uniprot P08173
DOI: 10.7270/q2z03d1v
title: BindingDB Entry 50014764: Discovery of

description: Small molecule binding data for protein Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, E3 ubiquitin-protein ligase Mdm2, and Potassium voltage-gated channel subfamily H member 2, Uniprot P08684, P10632, P10635, P11712, Q00987, and Q12809
DOI: 10.7270/q2tb1brw
title: BindingDB Entry 50014766: Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions.

description: Small molecule binding data for protein Tyrosine-protein phosphatase non-receptor type 11, Uniprot Q06124
DOI: 10.7270/q2pk0m1k
title: BindingDB Entry 50014768: Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent.

description: Small molecule binding data for protein Cyclin-dependent kinase 8, Uniprot P49336
DOI: 10.7270/q2js9v99
title: BindingDB Entry 50014769: Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase.

description: Small molecule binding data for protein Focal adhesion kinase 1, Uniprot Q05397
DOI: 10.7270/q2f193k8
title: BindingDB Entry 50014771: Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase.

description: Small molecule binding data for protein Sulfide:quinone oxidoreductase, mitochondrial, Uniprot Q9Y6N5
DOI: 10.7270/q2988bvj
title: BindingDB Entry 50014772: Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects.

description: Small molecule binding data for protein Delta-type opioid receptor, Kappa-type opioid receptor, and Mu-type opioid receptor, Uniprot P33533, P33535, P34975, and P35372
DOI: 10.7270/q25h7m47
title: BindingDB Entry 50014773: Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.

description: Small molecule binding data for protein Angiotensin-converting enzyme 2 and Spike glycoprotein, Uniprot P0DTC2 and Q9BYF1
DOI: 10.7270/q21r6vdh
title: BindingDB Entry 50014774: Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.

description: Small molecule binding data for protein Cytochrome P450 3A4, Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Poly [ADP-ribose] polymerase tankyrase-1, Poly [ADP-ribose] polymerase tankyrase-2, Potassium voltage-gated channel subfamily H member 2, Protein mono-ADP-ribosyltransferase PARP10, Protein mono-ADP-ribosyltransferase PARP12, Protein mono-ADP-ribosyltransferase PARP14, Protein mono-ADP-ribosyltransferase PARP15, Protein mono-ADP-ribosyltransferase PARP3, and Protein mono-ADP-ribosyltransferase PARP4, Uniprot O95271, P08684, P09874, Q12809, Q460N3, Q460N5, Q53GL7, Q9H0J9, Q9H2K2, Q9UGN5, Q9UKK3, and Q9Y6F1
DOI: 10.7270/q2x3529s
title: BindingDB Entry 50014776: A Series of Pyrazole Analogs Binding to KRASG12C as Potential Cancer Treatment.

description: Small molecule binding data for protein GTPase KRas, Uniprot P01116
DOI: 10.7270/q2sb49mh
title: BindingDB Entry 50014777: The Inhibitors of Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2) as Potential Enhancers of Cancer Immunotherapy and Type 1 (PTPN1) as Treatment of Metabolic Diseases.

description: Small molecule binding data for protein Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-protein phosphatase non-receptor type 2, Uniprot P17706 and P18031
DOI: 10.7270/q2nk3jws
title: BindingDB Entry 50014778: Novel Macrocyclic LRRK2 Inhibitors for Treating Parkinson's Disease.

description: Small molecule binding data for protein Leucine-rich repeat serine/threonine-protein kinase 2, Uniprot Q5S007
DOI: 10.7270/q2ht2t6x
title: BindingDB Entry 50014779: Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists.

description: Small molecule binding data for protein Prostaglandin E2 receptor EP1 subtype, Prostaglandin E2 receptor EP2 subtype, Prostaglandin E2 receptor EP3 subtype, and Prostaglandin E2 receptor EP4 subtype, Uniprot P34980, P34995, P35408, P43115, and P43116
DOI: 10.7270/q2d222gw
title: BindingDB Entry 50014781: Novel Isoindolone Compounds as HPK1 Inhibitors for Treating Cancer.

description: Small molecule binding data for protein Mitogen-activated protein kinase kinase kinase kinase 1, Uniprot Q92918
DOI: 10.7270/q28919qq
title: BindingDB Entry 50014782: Increased Molecular Flexibility Widens the Gap between

description: Small molecule binding data for protein Retinoic acid receptor RXR-alpha, Uniprot P19793
DOI: 10.7270/q24j0k0d
title: BindingDB Entry 50014784: Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.

description: Small molecule binding data for protein Nuclear receptor subfamily 4 group A member 1 and Nuclear receptor subfamily 4 group A member 2, Uniprot P22736 and P43354
DOI: 10.7270/q20v8hn0
title: BindingDB Entry 50014786: A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.

description: Small molecule binding data for protein Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 3, Protein arginine N-methyltransferase 6, and Protein arginine N-methyltransferase 8, Uniprot O60678, Q86X55, Q96LA8, Q99873, and Q9NR22