cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23591553.v1
title: Supplementary Material for: Relationship between plasma IP-10/CXCL10 levels and the initial therapeutic response in patients treated with Atezolizumab plus Bevacizumab for unresectable hepatocellular carcinoma

description: Introduction: Atezolizumab plus bevacizumab therapy (AB) was the first-line treatment for unresectable hepatocellular carcinoma (u-HCC). IFN-γ-induced protein 10 (IP-10/CXCL10) is a chemokine to inhibit HCC proliferation by promoting the migration of cytotoxic T cells. We focused on the relationship between plasma IP-10/CXCL10 levels and the initial therapeutic response in patients receiving AB therapy. Methods: Forty-six patients receiving AB therapy were enrolled. Plasma IP-10/CXCL10 levels were measured at baseline, 3-7 days, 3 weeks, 6 weeks, and 8-12 weeks after the start of AB therapy. The initial therapeutic response was evaluated at 8-12 weeks. Results: The baseline IP-10/CXCL10 levels of partial response (PR) group was higher than that of stable disease (SD) or progressive disease (PD) group. Patients with the baseline IP-10/CXCL10 of 84 pg/ml or higher were likely to present PR than patients below (71 vs. 35 %, p=0.031), but prediction of PD using the baseline IP-10/CXCL10 levels was difficult. In contrast, IP-10/CXCL10 ratio of the PR group was lower than that of the SD/PD group at 3, 6, and 8-12 weeks. Patients with the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio of 1.3, 0.4, and 0.4 or lower were likely to present PR than patients with ≥ 1.3, 0.4, and 0.4 (88, 35, 35 vs. 30, 3.8, 0%, p&lt;0.001, 0.011, 0.002). In other hand, the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio for PD group was higher than that for non-PD group. Patients with the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio of 1.3, 1.7, and 1.9 or higher were likely to present PD than patients below (85, 62, 57 vs. 32, 23, 14%, p=0.002, 0.034, 0.009). Conclusion: High baseline IP-10/CXCL10 levels may be associated with better outcome, and high IP-10/CXCL10 ratio after 3-12 weeks may be associated with worse outcome in u-HCC patients receiving AB therapy.
DOI: 10.6084/m9.figshare.23591556
title: Supplementary Material for: Relationship between plasma IP-10/CXCL10 levels and the initial therapeutic response in patients treated with Atezolizumab plus Bevacizumab for unresectable hepatocellular carcinoma

description: Introduction: Atezolizumab plus bevacizumab therapy (AB) was the first-line treatment for unresectable hepatocellular carcinoma (u-HCC). IFN-γ-induced protein 10 (IP-10/CXCL10) is a chemokine to inhibit HCC proliferation by promoting the migration of cytotoxic T cells. We focused on the relationship between plasma IP-10/CXCL10 levels and the initial therapeutic response in patients receiving AB therapy. Methods: Forty-six patients receiving AB therapy were enrolled. Plasma IP-10/CXCL10 levels were measured at baseline, 3-7 days, 3 weeks, 6 weeks, and 8-12 weeks after the start of AB therapy. The initial therapeutic response was evaluated at 8-12 weeks. Results: The baseline IP-10/CXCL10 levels of partial response (PR) group was higher than that of stable disease (SD) or progressive disease (PD) group. Patients with the baseline IP-10/CXCL10 of 84 pg/ml or higher were likely to present PR than patients below (71 vs. 35 %, p=0.031), but prediction of PD using the baseline IP-10/CXCL10 levels was difficult. In contrast, IP-10/CXCL10 ratio of the PR group was lower than that of the SD/PD group at 3, 6, and 8-12 weeks. Patients with the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio of 1.3, 0.4, and 0.4 or lower were likely to present PR than patients with ≥ 1.3, 0.4, and 0.4 (88, 35, 35 vs. 30, 3.8, 0%, p&lt;0.001, 0.011, 0.002). In other hand, the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio for PD group was higher than that for non-PD group. Patients with the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio of 1.3, 1.7, and 1.9 or higher were likely to present PD than patients below (85, 62, 57 vs. 32, 23, 14%, p=0.002, 0.034, 0.009). Conclusion: High baseline IP-10/CXCL10 levels may be associated with better outcome, and high IP-10/CXCL10 ratio after 3-12 weeks may be associated with worse outcome in u-HCC patients receiving AB therapy.
DOI: 10.6084/m9.figshare.23591556.v1
title: Supplementary Material for: Relationship between plasma IP-10/CXCL10 levels and the initial therapeutic response in patients treated with Atezolizumab plus Bevacizumab for unresectable hepatocellular carcinoma

description: Introduction: Atezolizumab plus bevacizumab therapy (AB) was the first-line treatment for unresectable hepatocellular carcinoma (u-HCC). IFN-γ-induced protein 10 (IP-10/CXCL10) is a chemokine to inhibit HCC proliferation by promoting the migration of cytotoxic T cells. We focused on the relationship between plasma IP-10/CXCL10 levels and the initial therapeutic response in patients receiving AB therapy. Methods: Forty-six patients receiving AB therapy were enrolled. Plasma IP-10/CXCL10 levels were measured at baseline, 3-7 days, 3 weeks, 6 weeks, and 8-12 weeks after the start of AB therapy. The initial therapeutic response was evaluated at 8-12 weeks. Results: The baseline IP-10/CXCL10 levels of partial response (PR) group was higher than that of stable disease (SD) or progressive disease (PD) group. Patients with the baseline IP-10/CXCL10 of 84 pg/ml or higher were likely to present PR than patients below (71 vs. 35 %, p=0.031), but prediction of PD using the baseline IP-10/CXCL10 levels was difficult. In contrast, IP-10/CXCL10 ratio of the PR group was lower than that of the SD/PD group at 3, 6, and 8-12 weeks. Patients with the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio of 1.3, 0.4, and 0.4 or lower were likely to present PR than patients with ≥ 1.3, 0.4, and 0.4 (88, 35, 35 vs. 30, 3.8, 0%, p&lt;0.001, 0.011, 0.002). In other hand, the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio for PD group was higher than that for non-PD group. Patients with the 3, 6, and 8–12 weeks IP-10/CXCL10 ratio of 1.3, 1.7, and 1.9 or higher were likely to present PD than patients below (85, 62, 57 vs. 32, 23, 14%, p=0.002, 0.034, 0.009). Conclusion: High baseline IP-10/CXCL10 levels may be associated with better outcome, and high IP-10/CXCL10 ratio after 3-12 weeks may be associated with worse outcome in u-HCC patients receiving AB therapy.
DOI: 10.15151/esrf-es-1262593440
title: XRF measurement of fixed, frozen hydrated mouse brain tissue

description: XRF imaging in frozen hydrated brain tissue
DOI: 10.15151/esrf-es-1117953598
title: Austrian Crystallographic Diffraction Consortium

description: This proposed Austrian Crystallographic.... TO BE FILLED IN
DOI: 10.15151/esrf-es-1108105347
title: Multi-scale Multi-techniques investigations of Li-ion batteries: towards a European Battery Hub

description: In this science-driven Long-Term proposal, we propose a 3-years multi-beamline program tackling grand challenges for actual, emerging and future battery technologies. We will deploy advanced methodologies for accelerating research by setting new cooperation modes for multi-techniques multi-scale studies. Three chemistry-neutral scientific cases have been identified to fulfil this LTP: bulk-to-surface mechanisms, high energy system and smart sensing. Multiple, time-coordinated, interoperable spectroscopic, imaging & scattering techniques will be implemented. This proposal is the Pilot Phase towards a European Battery Hub aiming at accelerating workflows in battery research by optimizing the exceptional diversity of means available at ESRF. We expect to demonstrate the added value of a new “proposal” mechanism, e.g. science-driven beamtime allocation group, serving the fast growing, highly competitive and rapidly evolving European battery community.
DOI: 10.15151/esrf-es-1259474105
title: High throughput measurements

description: Given that the high throughput powder diffraction setup will be set, we'd like to run some other samples.
DOI: 10.6084/m9.figshare.22261912.v7
title: 博士论文补充材料

description: Supplementary Dataset, MAGs (with locus_tag) and meta-transcripts
DOI: 10.6084/m9.figshare.23541058
title: Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses

description: Avian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all previously described AIV subtypes, derived from a cloacal swab sample of a Common Pochard (<i>Aythya ferina</i>) in Kazakhstan, in 2008. Avian influenza monitoring in wild birds especially in migratory hotspots such as central Asia is an important approach to gain information about the circulation of known and novel influenza viruses. Genetically, the novel HA coding sequence exhibits only 68.2% nucleotide and 68.5% amino acid identity with its nearest relation in the H9 (N2) subtype. The new HA sequence should be considered in current genomic diagnostic AI assays to facilitate its detection and eventual isolation enabling further study and antigenic classification.
DOI: 10.6084/m9.figshare.23541058.v2
title: Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses

description: Avian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all previously described AIV subtypes, derived from a cloacal swab sample of a Common Pochard (<i>Aythya ferina</i>) in Kazakhstan, in 2008. Avian influenza monitoring in wild birds especially in migratory hotspots such as central Asia is an important approach to gain information about the circulation of known and novel influenza viruses. Genetically, the novel HA coding sequence exhibits only 68.2% nucleotide and 68.5% amino acid identity with its nearest relation in the H9 (N2) subtype. The new HA sequence should be considered in current genomic diagnostic AI assays to facilitate its detection and eventual isolation enabling further study and antigenic classification.
DOI: 10.5281/zenodo.8088840
title: Dataset of chemicals of emerging concern detected in streams and rivers of Central Chile

description: This repository encompasses the environmental concentrations of chemicals of emerging concern (CECs) occurring in surface water samples obtained from streams and rivers in Central Chile, specifically the River Aconcagua basin.
DOI: 10.5281/zenodo.8088629
title: A federated learning framework based on transfer learning and knowledge distillation for targeted advertising-Ad Display/Click Data on Taobao.com dataset

description: https://tianchi.aliyun.com/dataset/56
DOI: 10.5281/zenodo.8088628
title: A federated learning framework based on transfer learning and knowledge distillation for targeted advertising-Ad Display/Click Data on Taobao.com dataset

description: https://tianchi.aliyun.com/dataset/56
DOI: 10.6084/m9.figshare.23591460.v1
title: PD_COP.mat

description: 15 Parkinson's Disease (PD) patients COP singals of anteroposterior-posterior (AP) direction
DOI: 10.6084/m9.figshare.23591460
title: PD_COP

description: 15 Parkinson's Disease (PD) patients COP singals of anteroposterior-posterior (AP) direction
DOI: 10.6084/m9.figshare.23591460.v3
title: PD_COP

description: 15 Parkinson's Disease (PD) patients COP singals of anteroposterior-posterior (AP) direction
DOI: 10.6084/m9.figshare.23591460.v2
title: PD_COP

description: 15 Parkinson's Disease (PD) patients COP singals of anteroposterior-posterior (AP) direction
DOI: 10.5281/zenodo.8009385
title: Data for Multidimensional diversity drives stability of mammal communities with large carnivores in temperate forests

description: R code and data for Multidimensional diversity drives stability of mammal communities with large carnivores in temperate forests
DOI: 10.5281/zenodo.8085816
title: SANS_Data_ANP-6

description: Excel file which contains:<br> A) Measured intensities<br> B) Fit data<br> C) Calculated size distribution<br> D) Main results<br> E) Annotations to Tables
DOI: 10.5281/zenodo.8085815
title: SANS_Data_ANP-6

description: Excel file which contains:<br> A) Measured intensities<br> B) Fit data<br> C) Calculated size distribution<br> D) Main results<br> E) Annotations to Tables
DOI: 10.5281/zenodo.8088991
title: Sluggish basal mantle structures support their long-lived stability

description: Dataset and script for "Sluggish basal mantle structures support their long-lived stability"
DOI: 10.5281/zenodo.8088990
title: Sluggish basal mantle structures support their long-lived stability

description: Dataset and script for "Sluggish basal mantle structures support their long-lived stability"
DOI: 10.5281/zenodo.7037326
title: Odor trail tracking data from DeepLabCut preprocessed for I-MuPPET

description: This data entry contains <strong>annotated mouse data </strong>from the<strong> DeepLabCut Nature Neuroscience paper</strong> preprocessed for <strong>I-MuPPET</strong>. Code for I-MuPPET available at https://github.com/urs-waldmann/i-muppet/.
DOI: 10.5281/zenodo.7037327
title: Odor trail tracking data from DeepLabCut preprocessed for I-MuPPET

description: This data entry contains <strong>annotated mouse data </strong>from the<strong> DeepLabCut Nature Neuroscience paper</strong> preprocessed for <strong>I-MuPPET</strong>. Code for I-MuPPET available at https://github.com/urs-waldmann/i-muppet/.
DOI: 10.6084/m9.figshare.23584722
title: Supplementary Material for: Diagnostic Utility and Safety of Non-Intubated Cryobiopsy Technique Using a Novel Ultrathin Cryoprobe in Addition to Conventional Biopsy Techniques for Peripheral Pulmonary Lesions

description: <b><i>Background:</i></b> Transbronchial cryobiopsy enables high-quality sample collection around the probe tip. Meanwhile, existing cryoprobes have less flexibility and a higher risk of bleeding. The ultrathin cryoprobe with a 1.1-mm diameter addresses these problems and allows specimens to be directly retrieved through the working channel of a thin bronchoscope. <b><i>Objective:</i></b> This study evaluated the diagnostic utility and safety of non-intubated cryobiopsy using an ultrathin cryoprobe added to conventional biopsy for diagnosing peripheral pulmonary lesions (PPLs). <b><i>Methods:</i></b> The data of patients who underwent conventional biopsy followed by non-intubated cryobiopsy to retrieve specimens through the thin bronchoscope’s working channel for diagnosing PPLs at Osaka Metropolitan University Hospital from July 2021 to June 2022 were retrospectively collected. They were analyzed to evaluate the diagnostic utility and safety of adding non-intubated cryobiopsy to conventional biopsy for PPLs. The characteristics of PPLs that obtain additional diagnostic benefits from cryobiopsy over conventional biopsy were also investigated. <b><i>Results:</i></b> The analysis included 113 patients. The diagnostic yields of conventional biopsy and non-intubated cryobiopsy were 70.8% and 82.3%, respectively (<i>p</i> = 0.009). The total diagnostic yield was 85.8%, higher than conventional biopsy alone (<i>p</i> &lt; 0.001). Although one moderate bleeding occurred, no severe complications developed. The additional diagnostic benefits of non-intubated cryobiopsy over conventional biopsy were demonstrated when the radial endobronchial ultrasound (R-EBUS) showed “adjacent to” (60.3% vs. 82.8%, <i>p</i> = 0.017). <b><i>Conclusions:</i></b> Non-intubated cryobiopsy using an ultrathin cryoprobe has high diagnostic utility and safety for diagnosing PPLs, with additional diagnostic benefits over conventional biopsy depending on the R-EBUS image.
DOI: 10.6084/m9.figshare.23584722.v1
title: Supplementary Material for: Diagnostic Utility and Safety of Non-Intubated Cryobiopsy Technique Using a Novel Ultrathin Cryoprobe in Addition to Conventional Biopsy Techniques for Peripheral Pulmonary Lesions

description: <b><i>Background:</i></b> Transbronchial cryobiopsy enables high-quality sample collection around the probe tip. Meanwhile, existing cryoprobes have less flexibility and a higher risk of bleeding. The ultrathin cryoprobe with a 1.1-mm diameter addresses these problems and allows specimens to be directly retrieved through the working channel of a thin bronchoscope. <b><i>Objective:</i></b> This study evaluated the diagnostic utility and safety of non-intubated cryobiopsy using an ultrathin cryoprobe added to conventional biopsy for diagnosing peripheral pulmonary lesions (PPLs). <b><i>Methods:</i></b> The data of patients who underwent conventional biopsy followed by non-intubated cryobiopsy to retrieve specimens through the thin bronchoscope’s working channel for diagnosing PPLs at Osaka Metropolitan University Hospital from July 2021 to June 2022 were retrospectively collected. They were analyzed to evaluate the diagnostic utility and safety of adding non-intubated cryobiopsy to conventional biopsy for PPLs. The characteristics of PPLs that obtain additional diagnostic benefits from cryobiopsy over conventional biopsy were also investigated. <b><i>Results:</i></b> The analysis included 113 patients. The diagnostic yields of conventional biopsy and non-intubated cryobiopsy were 70.8% and 82.3%, respectively (<i>p</i> = 0.009). The total diagnostic yield was 85.8%, higher than conventional biopsy alone (<i>p</i> &lt; 0.001). Although one moderate bleeding occurred, no severe complications developed. The additional diagnostic benefits of non-intubated cryobiopsy over conventional biopsy were demonstrated when the radial endobronchial ultrasound (R-EBUS) showed “adjacent to” (60.3% vs. 82.8%, <i>p</i> = 0.017). <b><i>Conclusions:</i></b> Non-intubated cryobiopsy using an ultrathin cryoprobe has high diagnostic utility and safety for diagnosing PPLs, with additional diagnostic benefits over conventional biopsy depending on the R-EBUS image.
DOI: 10.17632/xtgvw7rz65.1
title: Projections of wildfre weather danger in the Canary Islands

description: This data set corresponds to the referenced work (https://doi.org/10.1038/s41598-022-12132-5), related to climate projections, for the Canary Islands, of some risk indicators derived from the Canadian Forest Fire Weather Index (FWI). 

Climate regionalized projections for the Canary Islands were performed, at 3 km spatial resolution, using as boundary conditions some of the results provided by the Coupled Model Intercomparison Project (CMIP5) initiative, and covering the recent past (1980–2009) and future (2070–2099) periods, under two Representative Concentration Pathways, 4.5 and 8.5. A dynamical downscaling technique has been applied, using the Weather and Research and Forecasting (WRF) model driven by the results of three CMIP5 models (GFDL-ESM2M, IPSL-CM5A-MR and MIROC-ESM).

Each file, in netCDF format, has a name with the following nomenclature:

canary_VAR_PERIOD_FREQ_mean_WRF_driven_by_GCM.nc

where:
* VAR is the variable (fot30, fwi, lofs)
* PERIOD is the simulation period, and also indicates, for future periods, the corresponding emission scenario (1980_2009, 2070_2099_rcp45, 2070_2099_rcp85)
*FREQ is the frequency for data: year (mean value for the annual values of the whole period) or monthly (mean value for each month, that is, the average for all the januaries in the period, …)
* GCM is the global climate model (GCM) whose results have been used to drive the WRF simulations (GFDL_ESM2M, IPSL_CM5A_MR, MIROC_ESM)

The three variables provided are:
* fwi: monthly mean of daily values for the Canadian Forest Fire Weather Index (FWI). For this variable, results are also provided for a mid-century period (2030-2059).
* fot30: percentage of days with an FWI greater than 30. This value is usually considered as an indicator of severe fire danger situations.
* lofs: measures the extension in days of fire weather season. This starts/finishes each year when FWI exceeds/decreases the value 15 for more than two consecutive weeks. The provided values correspond to the average for each period analyzed.
DOI: 10.17632/6tj6fd4947.1
title: Projected impacts of climate change on tourism in the Canary Islands

description: This dataset corresponds to the referenced work (https://doi.org/10.1007/s10113-022-01880-9), related to climate projections, for the Canary Islands, of some tourism indices widely used in the literature (the Tourism Climate Index TCI and the Holiday Climate Index HCI). The HCI has been calculated for two types of tourist activities, resulting in two different indices: The HCI Beach index (HCIB) and the HCI Urban index (HCIU).
 
Regional climate simulations, at a 3 km resolution,  were computed using the Weather Research and Forecast (WRF) numerical weather prediction model driven by the results of three CMIP5
global climate models (GFDL-ESM2M, IPSL-CM5A-MR and MIROC-ESM) as boundary conditions. The simulations were performed for three 30-year periods, recent past (1980–2009), mid-century (2030–2059), and end-century (2070–2099). Two different future greenhouse gas emission scenarios (RCP4.5 and RCP8.5) have been used for the projections. 

Each file, in netCDF format, has a name with the following format:

canary_VAR_PERIOD_monthly_sum_WRF_driven_by_GCM.nc

where:
* VAR is the variable (HCIB60, HCIB80, HCIU60, HCIU80, TCI60, TCI80)
* PERIOD is the simulation period, and also indicates, for future periods, the corresponding emission scenario (1980_2009, 2030_2059_rcp45, 2030_2059_rcp85, 2070_2099_rcp45, 2070_2099_rcp85)
* GCM is the global climate model (GCM) whose results have been used to drive the WRF simulations (GFDL_ESM2M, IPSL_CM5A_MR, MIROC_ESM)

Each file contains 12 timesteps, one for each month (january, february, …). The content of the variables is the mean (over the 30-year period) percentage, for each month, of the days with a tourism index over 60 or 80. Thus, for example, HCIB60 is the percentage of days for which the HCIB index is over 60. For example, a value of 70 for january means that, in average (for the 30 januaries of the selected simulation), 70*31/100 = 21,7 days have an index over 60.

For the three used indices values over 60 are considered good to ideal conditions for the corresponding tourist activity, and values over 80 excellent or ideal conditions. Thus, HCIU80 indicates the percentage of days per month in which the conditions for urban tourism are excellent or ideal.
DOI: 10.6084/m9.figshare.23584785
title: Supplementary Material for: Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review

description: <b><i>Background:</i></b> Early diagnosis of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) by monitoring heart rate characteristics (HRC) of preterm infants might reduce the risk of death and morbidities. We aimed to systematically assess the effects of HRC monitoring on death, LOS, and NEC. <b><i>Methods:</i></b> A systematic search was performed in MEDLINE, Embase, Cochrane Library, and Web of Science. <b><i>Results:</i></b> Fifteen papers were included in this review. Three of these papers reported results from the only identified randomized controlled trial (RCT). This RCT showed that HRC monitoring resulted in a small but significant reduction in mortality (absolute risk reduction 2.1% [95% confidence interval 0.01–4.14]) without any differences in neurodevelopmental impairment. The risk of bias was rated high due to performance and detection bias and failure to correct for multiple testing. Most diagnostic cohort studies showed high discriminating accuracy in predicting LOS but lacked sufficient quality and generalizability. No studies for the detection of NEC were identified. <b><i>Conclusion:</i></b> Supported by multiple observational cohort studies, the RCT identified in this systematic review showed that HRC monitoring as an early warning system for LOS might reduce the risk of death in preterm infants. However, methodological weaknesses and limited generalizability do not justify implementation of HRC in clinical care. A large international RCT is warranted.