cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16494849
title: Magnetic and radiometric signatures of alkaline rocks and gabbros from the Ponta Grossa Arch, southeastern Paraná Basin, Brazil

description: Abstract We present airborne magnetic and radiometric characteristics of some igneous suites from the Ponta Grossa Arch Alkaline Province (southern Brazil), namely the Bairro da Cruz, Banhadão, Barra do Itapirapuã, Mato Preto and Tunas complexes, Barra do Teixeira Phonolite, Itapirapuã Nepheline syenite, and José Fernandes Gabbro. We applied magnetic susceptibility 3D inversions using the total magnetic anomaly data together with its analytic signal of the vertical integral and the vertical integral of the analytic signal for the Bairro da Cruz, José Fernandes, and Tunas intrusions. Gamma-ray spectrometric methods involved analyses of basic, ternary, and ratio maps, thorium-normalized parameters, and radioelement concentrations at sampled data points. Stacked profiles from geophysical data were generated for each rock. The Bairro da Cruz, José Fernandes, and Tunas intrusions are associated with dipolar anomalies with normal polarity whereas their inversions show low magnetic susceptibility values. Gamma-ray spectrometric results allowed us to verify that all complexes are enriched mainly in eTh. Carbonatite bodies showed the highest contents of eTh and eU. Our findings are consistent with geophysical responses of alkaline bodies and impact the understanding of geophysical signatures, especially radiometric ones, of alkaline provinces in Brazil.
DOI: 10.6084/m9.figshare.16494812
title: Chromium and energy restriction as substitutes for ractopamine in finishing gilts diet

description: ABSTRACT: This study evaluated chromium supplements and energy restriction as substitutes for ractopamine in the diets of late finishing gilts. Sixty gilts were used, with initial weights of 98.87 ± 0.25 kg and final weights of 122.69 ± 10.97 kg, distributed in a randomized block design with five diets: control; yeast chromium (0.8 ppm); chromium picolinate (0.48 ppm); ractopamine (20 ppm) and energy restriction (reduction of 150 kcal of EM kg-1 of feed), with six replicates and two animals per experimental unit. Feeding diet containing ractopamine enabled better (P&lt;0.05) feed conversion and greater weights of the hot carcass of the gilts. The diet containing ractopamine exhibited a lower (P&lt;0.05) cost of feed per kilogram of gain and higher economic efficiency, when compared to diets containing chromium and energy restriction; these exhibited better outcomes, compared to the control diet. Diets supplemented with chromium and ractopamine resulted in a higher (P&lt;0.05) percentage and quantity of lean meat and a higher rate of carcass bonus, when compared to the control diet and energy restriction. The energy reduction did not harm the gilts’ responses, compared to the control diet. Ractopamine supplementation allowed for a better feed conversion, lower feed cost per kilogram of gain, and a higher economic efficiency index. Supplements of chromium and ractopamine increased the percentage and quantity of lean meat and the bonus index of the carcasses. Therefore, chromium picolinate and chromium yeast are potential substitutes for ractopamine for optimizing the gilts carcass characteristics.
DOI: 10.6084/m9.figshare.16494849.v1
title: Magnetic and radiometric signatures of alkaline rocks and gabbros from the Ponta Grossa Arch, southeastern Paraná Basin, Brazil

description: Abstract We present airborne magnetic and radiometric characteristics of some igneous suites from the Ponta Grossa Arch Alkaline Province (southern Brazil), namely the Bairro da Cruz, Banhadão, Barra do Itapirapuã, Mato Preto and Tunas complexes, Barra do Teixeira Phonolite, Itapirapuã Nepheline syenite, and José Fernandes Gabbro. We applied magnetic susceptibility 3D inversions using the total magnetic anomaly data together with its analytic signal of the vertical integral and the vertical integral of the analytic signal for the Bairro da Cruz, José Fernandes, and Tunas intrusions. Gamma-ray spectrometric methods involved analyses of basic, ternary, and ratio maps, thorium-normalized parameters, and radioelement concentrations at sampled data points. Stacked profiles from geophysical data were generated for each rock. The Bairro da Cruz, José Fernandes, and Tunas intrusions are associated with dipolar anomalies with normal polarity whereas their inversions show low magnetic susceptibility values. Gamma-ray spectrometric results allowed us to verify that all complexes are enriched mainly in eTh. Carbonatite bodies showed the highest contents of eTh and eU. Our findings are consistent with geophysical responses of alkaline bodies and impact the understanding of geophysical signatures, especially radiometric ones, of alkaline provinces in Brazil.
DOI: 10.6084/m9.figshare.16494812.v1
title: Chromium and energy restriction as substitutes for ractopamine in finishing gilts diet

description: ABSTRACT: This study evaluated chromium supplements and energy restriction as substitutes for ractopamine in the diets of late finishing gilts. Sixty gilts were used, with initial weights of 98.87 ± 0.25 kg and final weights of 122.69 ± 10.97 kg, distributed in a randomized block design with five diets: control; yeast chromium (0.8 ppm); chromium picolinate (0.48 ppm); ractopamine (20 ppm) and energy restriction (reduction of 150 kcal of EM kg-1 of feed), with six replicates and two animals per experimental unit. Feeding diet containing ractopamine enabled better (P&lt;0.05) feed conversion and greater weights of the hot carcass of the gilts. The diet containing ractopamine exhibited a lower (P&lt;0.05) cost of feed per kilogram of gain and higher economic efficiency, when compared to diets containing chromium and energy restriction; these exhibited better outcomes, compared to the control diet. Diets supplemented with chromium and ractopamine resulted in a higher (P&lt;0.05) percentage and quantity of lean meat and a higher rate of carcass bonus, when compared to the control diet and energy restriction. The energy reduction did not harm the gilts’ responses, compared to the control diet. Ractopamine supplementation allowed for a better feed conversion, lower feed cost per kilogram of gain, and a higher economic efficiency index. Supplements of chromium and ractopamine increased the percentage and quantity of lean meat and the bonus index of the carcasses. Therefore, chromium picolinate and chromium yeast are potential substitutes for ractopamine for optimizing the gilts carcass characteristics.
DOI: 10.6084/m9.figshare.16494931
title: Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice

description: Abstract Background: Phoneutria nigriventer venom contains Phα1β. This toxin and its recombinant form have a remarkable analgesic potential that is associated with blockage of voltage-gated calcium channels and TRPA1 receptors. Although morphine is a mainstay drug to treat moderate and severe pain related to cancer, it has serious and dose-limiting side effects. Combining recombinant Phα1β and morphine to treat pain is an interesting approach that has been gaining attention. Therefore, a quantitative and reliable method to establish the strength of the antinociceptive interaction between these two substances is necessary. The present study was designed to investigate the nature of the functional antinociceptive (analgesic) interaction between Phα1β recombinant toxin and morphine in a model of cancer pain. Methods: Melanoma was produced by intraplantar inoculation of B16-F10 cells into the right paw of C57BL/6J mice. Von Frey filaments measured the paw-withdrawal threshold after intrathecal administration of morphine, recombinant Phα1β, and their combination. Thermal hyperalgesia was assessed using Hargreaves apparatus. The degree of interaction was evaluated using isobolographic analysis. Spontaneous and forced motor performance was assessed with the open-field and rotarod tests, respectively. Results: Co-administration of recombinant Phα1β and morphine synergistically reverses the melanoma-induced mechanical hyperalgesia. The potency of the mixture, measured as the effective dose to reach 50% of maximum possible effect (MPE) in ameliorating mechanical hyperalgesia, was about twice fold higher than expected if the interaction between morphine and recombinant Phα1β was merely additive. Treatment with the combination at doses necessary to reach 50% of MPE caused no spontaneous nor forced motor alterations. Conclusion: The combinatorial use of recombinant Phα1β and morphine allows significant and effective dose reduction of both agents, which has translational potential for opioid-sparing approaches in pain management related to cancer.
DOI: 10.6084/m9.figshare.16494931.v1
title: Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice

description: Abstract Background: Phoneutria nigriventer venom contains Phα1β. This toxin and its recombinant form have a remarkable analgesic potential that is associated with blockage of voltage-gated calcium channels and TRPA1 receptors. Although morphine is a mainstay drug to treat moderate and severe pain related to cancer, it has serious and dose-limiting side effects. Combining recombinant Phα1β and morphine to treat pain is an interesting approach that has been gaining attention. Therefore, a quantitative and reliable method to establish the strength of the antinociceptive interaction between these two substances is necessary. The present study was designed to investigate the nature of the functional antinociceptive (analgesic) interaction between Phα1β recombinant toxin and morphine in a model of cancer pain. Methods: Melanoma was produced by intraplantar inoculation of B16-F10 cells into the right paw of C57BL/6J mice. Von Frey filaments measured the paw-withdrawal threshold after intrathecal administration of morphine, recombinant Phα1β, and their combination. Thermal hyperalgesia was assessed using Hargreaves apparatus. The degree of interaction was evaluated using isobolographic analysis. Spontaneous and forced motor performance was assessed with the open-field and rotarod tests, respectively. Results: Co-administration of recombinant Phα1β and morphine synergistically reverses the melanoma-induced mechanical hyperalgesia. The potency of the mixture, measured as the effective dose to reach 50% of maximum possible effect (MPE) in ameliorating mechanical hyperalgesia, was about twice fold higher than expected if the interaction between morphine and recombinant Phα1β was merely additive. Treatment with the combination at doses necessary to reach 50% of MPE caused no spontaneous nor forced motor alterations. Conclusion: The combinatorial use of recombinant Phα1β and morphine allows significant and effective dose reduction of both agents, which has translational potential for opioid-sparing approaches in pain management related to cancer.
DOI: 10.6084/m9.figshare.16495008
title: Impact of headache on a supplemental healthcare emergency unit and on use of opioids

description: ABSTRACT Background: Headache is one of the most common causes of emergency care and migraines are the most common primary headache in this regard. Objective: The aim of this research study was to assess the incidence of medical consultations due to headache, along with demographic characteristics and treatments pertaining to cephalalgia that were offered to patients cared for in supplemental healthcare emergency rooms. Methods: In 2017, a total of 11,105 consultations took place, and 4,865 (43.8%) of them were complaints relating to headache. 407 records of patients with headache were randomly selected and assessed. Demographic, clinical and therapeutic data were collected using a structured form. Results: The cause of headache was diagnosed as migraine in 60.0% of the patient records. Patients were mostly female (75.2%), with an average age of 33.9 ± 13.7 years. Patient management consisted of administering dipyrone in 62.4% of cases, antiemetics in 66.9%, corticosteroids in 58.9%, opioids in 24.3% and NSAIDs in 13.5%. Use of opioids was associated with a diagnosis of migraine (OR 2.4; CI 1.4-3.9; p = 0.001). Patients who received opioids were kept under observation for longer periods of time (OR 3.4; CI 2.1-5.4; p &lt; 0.001) and exhibited a higher rate of use of antiemetics (OR 11.0; CI 4.7-25.9; p &lt; 0.001), compared with patients who did not receive opioids. Conclusion: Dipyrone and antiemetics were administered to most of the patients. Opioids were used for a significant proportion of these individuals, despite the diagnosis of migraine, a condition for which their use is discouraged.
DOI: 10.6084/m9.figshare.16495008.v1
title: Impact of headache on a supplemental healthcare emergency unit and on use of opioids

description: ABSTRACT Background: Headache is one of the most common causes of emergency care and migraines are the most common primary headache in this regard. Objective: The aim of this research study was to assess the incidence of medical consultations due to headache, along with demographic characteristics and treatments pertaining to cephalalgia that were offered to patients cared for in supplemental healthcare emergency rooms. Methods: In 2017, a total of 11,105 consultations took place, and 4,865 (43.8%) of them were complaints relating to headache. 407 records of patients with headache were randomly selected and assessed. Demographic, clinical and therapeutic data were collected using a structured form. Results: The cause of headache was diagnosed as migraine in 60.0% of the patient records. Patients were mostly female (75.2%), with an average age of 33.9 ± 13.7 years. Patient management consisted of administering dipyrone in 62.4% of cases, antiemetics in 66.9%, corticosteroids in 58.9%, opioids in 24.3% and NSAIDs in 13.5%. Use of opioids was associated with a diagnosis of migraine (OR 2.4; CI 1.4-3.9; p = 0.001). Patients who received opioids were kept under observation for longer periods of time (OR 3.4; CI 2.1-5.4; p &lt; 0.001) and exhibited a higher rate of use of antiemetics (OR 11.0; CI 4.7-25.9; p &lt; 0.001), compared with patients who did not receive opioids. Conclusion: Dipyrone and antiemetics were administered to most of the patients. Opioids were used for a significant proportion of these individuals, despite the diagnosis of migraine, a condition for which their use is discouraged.
DOI: 10.5281/zenodo.6584185
title: DriverMVT (Part 2)

description: DriverMVT (Driver Monitoring dataset with Videos and Telemetry). The dataset contains information about the driver head pose, heart rate, and driver behaviour inside the cabin like drowsiness and unfastened belt. This dataset can be used to train and evaluate deep learning models to estimate the driver’s health state, mental state, concentration level, and his/her activity in the cabin.
DOI: 10.6084/m9.figshare.16495084
title: Hydrogeological compartmentalization and connection of the Guarani (GAS) and Serra Geral (SGAS) aquifer systems from a multiscale perspective: a case study in southern Brazil

description: Abstract The Guarani (GAS) and Serra Geral (SGAS) aquifer systems are the main groundwater sources in southern Brazil. We investigated the crucial relationship between the primary, intergranular pore system in the GAS and the secondary pore system associated with fractures in the SGAS in order to understand better the compartmentalization and connection, water storage, and productivity of both aquifers. Data from 375 wells that produce from both aquifers was used to evaluate the hydrodynamic characteristics of the GAS-SGAS contact. The integration of data using remote sensing, structural data, and thin section analysis support interpretations about the compartmentalization and potential connection of the aquifers. Fault zones trending NW, EW, and NNE demarcate six structural blocks in which the GAS-SGAS contact varies more than 400 m in elevation. Thin section analysis of sandstone texture and composition allowed us to determine the relationship between the type of porosity and cement type and content. The surface demarcating the Guarani-Serra Geral contact is highly productive in 93% of the wells that reach both aquifers. The integration of our results allowed us to propose a conceptual hydrogeological model for the GAS and SGAS aquifers in the study area.
DOI: 10.6084/m9.figshare.16495084.v1
title: Hydrogeological compartmentalization and connection of the Guarani (GAS) and Serra Geral (SGAS) aquifer systems from a multiscale perspective: a case study in southern Brazil

description: Abstract The Guarani (GAS) and Serra Geral (SGAS) aquifer systems are the main groundwater sources in southern Brazil. We investigated the crucial relationship between the primary, intergranular pore system in the GAS and the secondary pore system associated with fractures in the SGAS in order to understand better the compartmentalization and connection, water storage, and productivity of both aquifers. Data from 375 wells that produce from both aquifers was used to evaluate the hydrodynamic characteristics of the GAS-SGAS contact. The integration of data using remote sensing, structural data, and thin section analysis support interpretations about the compartmentalization and potential connection of the aquifers. Fault zones trending NW, EW, and NNE demarcate six structural blocks in which the GAS-SGAS contact varies more than 400 m in elevation. Thin section analysis of sandstone texture and composition allowed us to determine the relationship between the type of porosity and cement type and content. The surface demarcating the Guarani-Serra Geral contact is highly productive in 93% of the wells that reach both aquifers. The integration of our results allowed us to propose a conceptual hydrogeological model for the GAS and SGAS aquifers in the study area.
DOI: 10.5281/zenodo.6584184
title: DriverMVT (Part 2)

description: DriverMVT (Driver Monitoring dataset with Videos and Telemetry). The dataset contains information about the driver head pose, heart rate, and driver behaviour inside the cabin like drowsiness and unfastened belt. This dataset can be used to train and evaluate deep learning models to estimate the driver’s health state, mental state, concentration level, and his/her activity in the cabin.
DOI: 10.6084/m9.figshare.16495062
title: Horner syndrome: tribute to Professor Horner on his 190th birthday

description: Abstract This paper reviews some aspects of the life and work of Professor Johann Friedrich Horner, on the occasion of the 190th anniversary of his birthday and 152 years after the publication of "Über eine Form von Ptosis". It also shows the importance of the historical description of ptosis, myosis and anhidrosis associating those symptoms with sympathetic cervical damage. He pharmacologically confirmed the impairment of sympathetic innervation to the eye and preserved parasympathetic function.
DOI: 10.6084/m9.figshare.16495062.v1
title: Horner syndrome: tribute to Professor Horner on his 190th birthday

description: Abstract This paper reviews some aspects of the life and work of Professor Johann Friedrich Horner, on the occasion of the 190th anniversary of his birthday and 152 years after the publication of "Über eine Form von Ptosis". It also shows the importance of the historical description of ptosis, myosis and anhidrosis associating those symptoms with sympathetic cervical damage. He pharmacologically confirmed the impairment of sympathetic innervation to the eye and preserved parasympathetic function.
DOI: 10.6073/pasta/6d4271aa843e748d6c2ad58bc42f4690
title: Macrosystems EDDIE Module 5: Introduction to Ecological Forecasting (Instructor Materials)

description: Ecological forecasting is a tool that can be used for understanding and predicting changes in populations, communities, and ecosystems. Ecological forecasting is an emerging approach which provides an estimate of the future state of an ecological system with uncertainty, allowing society to prepare for changes in important ecosystem services. Ecological forecasters develop and update forecasts using the iterative forecasting cycle, in which they make a hypothesis of how an ecological system works; embed their hypothesis in a model; and use the model to make a forecast of future conditions. When observations become available, they can assess the accuracy of their forecast, which indicates if their hypothesis is supported or needs to be updated before the next forecast is generated. In this Macrosystems EDDIE (Environmental Data-Driven Inquiry & Exploration) module, students will apply the iterative forecasting cycle to develop an ecological forecast for a National Ecological Observation Network (NEON) site. Students will use NEON data to build an ecological model that predicts primary productivity. Using their calibrated model, they will learn about the different components of a forecast with uncertainty and compare productivity forecasts among NEON sites. The overarching goal of this module is for students to learn fundamental concepts about ecological forecasting and build a forecast for a NEON site. Students will work with an R Shiny interface to visualize data, build a model, generate a forecast with uncertainty, and then compare the forecast with observations. The A-B-C structure of this module makes it flexible and adaptable to a range of student levels and course structures. This EDI data package contains instructional materials and the files necessary to teach the module. Readers are referred to the Zenodo data package (Moore et al. 2022; DOI: 10.5281/zenodo.6363500) for the R Shiny application code needed to run the module locally.
DOI: 10.6084/m9.figshare.16495128
title: Myasthenia gravis during pregnancy: what care should be taken?

description: Abstract Myasthenia gravis (MG) is an autoimmune disease in which the peak incidence is among women of childbearing age. For this reason, there is an overlap between the occurrence of this disease and pregnancy. It is known that MG symptoms can worsen during pregnancy and postpartum, and that pregnancy has special characteristics in MG patients. Children born to myasthenic mothers are at risk of having transient neonatal myasthenia. We briefly review the main relationships between MG and pregnancy, and we make recommendations for MG therapy, pregnancy, delivery, breastfeeding and newborns.
DOI: 10.6084/m9.figshare.16495128.v1
title: Myasthenia gravis during pregnancy: what care should be taken?

description: Abstract Myasthenia gravis (MG) is an autoimmune disease in which the peak incidence is among women of childbearing age. For this reason, there is an overlap between the occurrence of this disease and pregnancy. It is known that MG symptoms can worsen during pregnancy and postpartum, and that pregnancy has special characteristics in MG patients. Children born to myasthenic mothers are at risk of having transient neonatal myasthenia. We briefly review the main relationships between MG and pregnancy, and we make recommendations for MG therapy, pregnancy, delivery, breastfeeding and newborns.