cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7488542
title: Dataset related to the publication "Mapelli M, Romani S, Magri D, Merlo M, Cittar M, Mase M, et al. Exercise oxygen pulse kinetics in patients with hypertrophic cardiomyopathy". Heart.

description: <strong>Objectives: </strong>Reduced cardiac output (CO) has been considered crucial in symptoms' genesis in hypertrophic cardiomyopathy (HCM). Absolute value and temporal behaviour of O<sub>2</sub>-pulse (oxygen uptake/heart rate (VO<sub>2</sub>/HR)), and the VO<sub>2</sub>/work relationship during exercise reflect closely stroke volume (SV) and CO changes, respectively. We hypothesise that adding O<sub>2</sub>-pulse absolute value and kinetics, and VO<sub>2</sub>/work relationship to standard cardiopulmonary exercise testing (CPET) could help identify more exercise-limited patients with HCM. <strong>Methods: </strong>CPETs were performed in 3 HCM dedicated clinical units. We retrospectively enrolled non-end-stage consecutive patients with HCM, grouped according to left ventricle outflow tract obstruction (LVOTO) at rest or during Valsalva manoeuvre (72% of patients with LVOTO &lt;30; 10% between 30 and 49 and 18% ≥50 mm Hg). We evaluated the CPET response in HCM focusing on parameters strongly associated with SV and CO, such as O<sub>2</sub>-pulse and VO<sub>2</sub>, respectively, considering their absolute values and temporal behaviour during exercise. <strong>Results: </strong>We included 312 patients (70% males, age 49±18 years). Peak VO<sub>2</sub> (percentage of predicted), O<sub>2</sub>-pulse and ventilation to carbon dioxide production (VE/VCO<sub>2</sub>) slope did not change across LVOTO groups. Ninety-six (31%) patients with HCM presented an abnormal O<sub>2</sub>-pulse temporal behaviour, irrespective of LVOTO values. These patients showed lower peak systolic pressure, workload (106±45 vs 130±49 W), VO<sub>2</sub> (21.3±6.6 vs 24.1±7.7 mL/min/kg; 74%±17% vs 80%±20%) and O<sub>2</sub>-pulse (12 (9-14) vs 14 (11-17) mL/beat), with higher VE/VCO<sub>2</sub> slope (28 (25-31) vs 27 (24-31)) (p&lt;0.005 for all). Only 2 patients had an abnormal VO<sub>2</sub>/work slope. <strong>Conclusion: </strong>None of the frequently used CPET parameters, either as absolute values or dynamic relationships, were associated with LVOTO. Differently, an abnormal temporal behaviour of O<sub>2</sub>-pulse during exercise, which is strongly related to inadequate SV increase, correlates with reduced functional capacity (peak and anaerobic threshold VO<sub>2</sub> and workload) and increased VE/VCO<sub>2</sub> slope, identifying more advanced disease irrespectively of LVOTO.
DOI: 10.6084/m9.figshare.21803049.v1
title: Supplementary Material for: A Case of Intraocular Cilium after 25-Gauge Micro-Incision Vitrectomy Surgery

description: We report a case of intraocular cilium after micro-incision vitrectomy surgery for retinal detachment. A 61-year-old male underwent vitrectomy with cataract surgery for rhegmatogenous retinal detachment. The postoperative course was generally good with no re-detachment, but on examination 3 months later, a cilium was observed on the retina above the fundus. After discussing with the patient, it was decided to take no immediate action and just continuously monitor the patient in order to detect if there was worsening of any of the symptoms. The present case report suggests that foreign bodies such as cilium may stray into the eye through trocar even during vitrectomy. One of the possible causes was the risk of the noncontact wide-angle viewing system.
DOI: 10.5281/zenodo.7464392
title: Dataset related to the article "LUMINAL ENDOTHELIALIZATION OF SMALL CALIBER SILK TUBULAR GRAFT FOR VASCULAR CONSTRUCTS ENGINEERING"

description: This record contains raw data related to the article “LUMINAL ENDOTHELIALIZATION OF SMALL CALIBER SILK TUBULAR GRAFT FOR VASCULAR CONSTRUCTS ENGINEERING" The constantly increasing incidence of coronary artery disease worldwide makes necessary to set advanced therapies and tools such as tissue engineered vessel grafts (TEVGs) to surpass the autologous grafts [(i.e., mammary and internal thoracic arteries, saphenous vein (SV)] currently employed in coronary artery and vascular surgery. To this aim, <em>in vitro</em> cellularization of artificial tubular scaffolds still holds a good potential to overcome the unresolved problem of vessel conduits availability and the issues resulting from thrombosis, intima hyperplasia and matrix remodeling, occurring in autologous grafts especially with small caliber (&lt;6 mm). The employment of silk-based tubular scaffolds has been proposed as a promising approach to engineer small caliber cellularized vascular constructs. The advantage of the silk material is the excellent manufacturability and the easiness of fiber deposition, mechanical properties, low immunogenicity and the extremely high <em>in vivo</em> biocompatibility. In the present work, we propose a method to optimize coverage of the luminal surface of silk electrospun tubular scaffold with endothelial cells. Our strategy is based on seeding endothelial cells (ECs) on the luminal surface of the scaffolds using a low-speed rolling. We show that this procedure allows the formation of a nearly complete EC monolayer suitable for flow-dependent studies and vascular maturation, as a step toward derivation of complete vascular constructs for transplantation and disease modeling.
description: This present work has been funded by the Institutional project grants at Centro Cardiologico Monzino (Ricerca Corrente; Progetto 5 per 1000), issued to MP.
DOI: 10.5281/zenodo.7464393
title: Dataset related to the article "LUMINAL ENDOTHELIALIZATION OF SMALL CALIBER SILK TUBULAR GRAFT FOR VASCULAR CONSTRUCTS ENGINEERING"

description: This record contains raw data related to the article “LUMINAL ENDOTHELIALIZATION OF SMALL CALIBER SILK TUBULAR GRAFT FOR VASCULAR CONSTRUCTS ENGINEERING" The constantly increasing incidence of coronary artery disease worldwide makes necessary to set advanced therapies and tools such as tissue engineered vessel grafts (TEVGs) to surpass the autologous grafts [(i.e., mammary and internal thoracic arteries, saphenous vein (SV)] currently employed in coronary artery and vascular surgery. To this aim, <em>in vitro</em> cellularization of artificial tubular scaffolds still holds a good potential to overcome the unresolved problem of vessel conduits availability and the issues resulting from thrombosis, intima hyperplasia and matrix remodeling, occurring in autologous grafts especially with small caliber (&lt;6 mm). The employment of silk-based tubular scaffolds has been proposed as a promising approach to engineer small caliber cellularized vascular constructs. The advantage of the silk material is the excellent manufacturability and the easiness of fiber deposition, mechanical properties, low immunogenicity and the extremely high <em>in vivo</em> biocompatibility. In the present work, we propose a method to optimize coverage of the luminal surface of silk electrospun tubular scaffold with endothelial cells. Our strategy is based on seeding endothelial cells (ECs) on the luminal surface of the scaffolds using a low-speed rolling. We show that this procedure allows the formation of a nearly complete EC monolayer suitable for flow-dependent studies and vascular maturation, as a step toward derivation of complete vascular constructs for transplantation and disease modeling.
description: This present work has been funded by the Institutional project grants at Centro Cardiologico Monzino (Ricerca Corrente; Progetto 5 per 1000), issued to MP.
DOI: 10.5281/zenodo.7477491
title: Raw data of "Old and new equations for maximal heart rate prediction in patients with heart failure and reduced ejection fraction on beta-blockers treatment: results from the MECKI score data set"

description: AIMS: Predicting maximal heart rate (MHR) in heart failure with reduced ejection fraction (HFrEF) still remains a major concern. In such a context, the Keteyian equation is the only one derived in a HFrEF cohort on optimized beta-blockers treatment. Therefore, using the Metabolic Exercise combined with Cardiac and Kidney Indexes (MECKI) data set, we looked for a possible MHR equation, for an external validation of Keteyien formula and, contextually, for accuracy of the historical MHR formulas and their relationship with the HR measured at the anaerobic threshold (AT). METHODS AND RESULTS: Data from 3487 HFrEF outpatients on optimized beta-blockers treatment from the MECKI data set were analyzed. Besides excluding all possible confounders, the new equation was derived by using HR data coming from maximal cardiopulmonary exercise test. The simplified derived equation was [109-(0.5*age) + (0.5*HR rest) + (0.2*LVEF)-(5 if haemoglobin &lt;11 g/dL)]. The R2 and the standard error of the estimate were 0.24 and 17.5 beats min-1 with a mean absolute percentage error (MAPE) = 11.9%. The Keteyian equation had a slightly higher MAPE = 12.3%. Conversely, the Fox and Tanaka equations showed extremely higher MAPE values. The range 75-80% of MHR according to the new and the Keteyian equations was the most accurate in identifying the HR at the AT (MAPEs = 11.3-11.6%). CONCLUSION: The derived equation to estimate the MHR in HFrEF patients, by accounting also for the systolic dysfunction degree and anaemia, improved slightly the Keteyian formula. Both formulas might be helpful in identifying the true maximal effort during an exercise test and the intensity domain during a rehabilitation programme.
DOI: 10.5281/zenodo.7477492
title: Raw data of "Old and new equations for maximal heart rate prediction in patients with heart failure and reduced ejection fraction on beta-blockers treatment: results from the MECKI score data set"

description: AIMS: Predicting maximal heart rate (MHR) in heart failure with reduced ejection fraction (HFrEF) still remains a major concern. In such a context, the Keteyian equation is the only one derived in a HFrEF cohort on optimized beta-blockers treatment. Therefore, using the Metabolic Exercise combined with Cardiac and Kidney Indexes (MECKI) data set, we looked for a possible MHR equation, for an external validation of Keteyien formula and, contextually, for accuracy of the historical MHR formulas and their relationship with the HR measured at the anaerobic threshold (AT). METHODS AND RESULTS: Data from 3487 HFrEF outpatients on optimized beta-blockers treatment from the MECKI data set were analyzed. Besides excluding all possible confounders, the new equation was derived by using HR data coming from maximal cardiopulmonary exercise test. The simplified derived equation was [109-(0.5*age) + (0.5*HR rest) + (0.2*LVEF)-(5 if haemoglobin &lt;11 g/dL)]. The R2 and the standard error of the estimate were 0.24 and 17.5 beats min-1 with a mean absolute percentage error (MAPE) = 11.9%. The Keteyian equation had a slightly higher MAPE = 12.3%. Conversely, the Fox and Tanaka equations showed extremely higher MAPE values. The range 75-80% of MHR according to the new and the Keteyian equations was the most accurate in identifying the HR at the AT (MAPEs = 11.3-11.6%). CONCLUSION: The derived equation to estimate the MHR in HFrEF patients, by accounting also for the systolic dysfunction degree and anaemia, improved slightly the Keteyian formula. Both formulas might be helpful in identifying the true maximal effort during an exercise test and the intensity domain during a rehabilitation programme.
DOI: 10.5281/zenodo.7468226
title: Dataset related to the article "LITHOTRIPSY OF CALCIFIED AORTIC VALVE LEAFLETS BY A NOVEL ULTRASOUND TRANSCATHETER-BASED DEVICE"

description: This record contains raw data related to the article “LITHOTRIPSY OF CALCIFIED AORTIC VALVE LEAFLETS BY A NOVEL ULTRASOUND TRANSCATHETER-BASED DEVICE” The increasing incidence of calcific aortic valve disease necessitates the elaboration of new strategies to retard the progression of the pathology with an innovative solution. While the increasing diffusion of the transcatheter aortic valve replacements (TAVRs) allows a mini-invasive approach to aortic valve substitution as an alternative to conventional surgical replacement (SAVR) in an always larger patient population, TAVR implantation still has contraindications for young patients. In addition, it is liable to undergo calcification with the consequent necessity of re-intervention with conventional valve surgery or repeated implantation in the so-called TAVR-in-TAVR procedure. Inspired by applications for non-cardiac pathologies or for vascular decalcification before stenting (i.e., coronary lithotripsy), in the present study, we show the feasibility of human valve treatment with a mini-invasive device tailored to deliver shockwaves to the calcific leaflets. We provide evidence of efficient calcium deposit ruptures in human calcified leaflets treated <em>ex vivo</em> and the safety of the treatment in pigs. The use of this device could be helpful to perform shockwaves valvuloplasty as an option to retard TAVR/SAVR, or as a pretreatment to facilitate prosthesis implantation and minimize the occurrence of paravalvular leak.
description: GB, GG, SR, MB, CR, MA, GP, and MP are supported by institutional funding (Ricerca Corrente, Ricerca 5 per mille – Ministero della Salute, Italy). DV and MLB are supported by the local funding program RFO-UNIBO.
DOI: 10.5281/zenodo.7468227
title: Dataset related to the article "LITHOTRIPSY OF CALCIFIED AORTIC VALVE LEAFLETS BY A NOVEL ULTRASOUND TRANSCATHETER-BASED DEVICE"

description: This record contains raw data related to the article “LITHOTRIPSY OF CALCIFIED AORTIC VALVE LEAFLETS BY A NOVEL ULTRASOUND TRANSCATHETER-BASED DEVICE” The increasing incidence of calcific aortic valve disease necessitates the elaboration of new strategies to retard the progression of the pathology with an innovative solution. While the increasing diffusion of the transcatheter aortic valve replacements (TAVRs) allows a mini-invasive approach to aortic valve substitution as an alternative to conventional surgical replacement (SAVR) in an always larger patient population, TAVR implantation still has contraindications for young patients. In addition, it is liable to undergo calcification with the consequent necessity of re-intervention with conventional valve surgery or repeated implantation in the so-called TAVR-in-TAVR procedure. Inspired by applications for non-cardiac pathologies or for vascular decalcification before stenting (i.e., coronary lithotripsy), in the present study, we show the feasibility of human valve treatment with a mini-invasive device tailored to deliver shockwaves to the calcific leaflets. We provide evidence of efficient calcium deposit ruptures in human calcified leaflets treated <em>ex vivo</em> and the safety of the treatment in pigs. The use of this device could be helpful to perform shockwaves valvuloplasty as an option to retard TAVR/SAVR, or as a pretreatment to facilitate prosthesis implantation and minimize the occurrence of paravalvular leak.
description: GB, GG, SR, MB, CR, MA, GP, and MP are supported by institutional funding (Ricerca Corrente, Ricerca 5 per mille – Ministero della Salute, Italy). DV and MLB are supported by the local funding program RFO-UNIBO.
DOI: 10.5281/zenodo.7477263
title: Row data of the publication: Can beta-blockers influence regular daily physical activity?

description: Raw data BACKGROUND: In hypertension, beta-blockers have a high rate of nonadherence to treatment likely because of fatigue. METHODS: We evaluate daily physical activity and maximal exercise performance in 56 patients with hypertension (grades I-II), with and without beta-blockers (bisoprolol 10 mg or atenolol 100 mg) added to standard treatment; 48 patients completed the study. Study tests were performed after 8 weeks of antihypertensive therapy without beta blockers and after the following 8 weeks with beta-blockers. RESULTS: No significant differences between beta-blockers were observed. At office measurement, beta-blockers decreased heart rate (HR) from 78 +/- 9 to 62 +/- 7 bpm (P &lt; 0.01) and SBP from 133 +/- 13 to 125 +/- 12 mmHg (P &lt; 0.01). No significant changes were observed for DBP. Conversely, at ambulatory pressure monitoring DBP but not SBP decreased with beta-blockers (mean-24-h DBP 77 +/- 8 vs. 74 +/- 7 mmHg, P &lt; 0.01). An overall reduction of daily activities and of estimated kilocalories consumption was observed as measured by a portable armband device. Of note, time with activity more than 3 METS was reduced by beta-blockers from 148.1 (83-201) to 117.9 (82-189) min (P &lt; 0.01). Cardiopulmonary exercise (CPE) showed a preserved exercise performance unaffected by beta-blockers. CONCLUSION: In hypertension, beta-blocker treatment is associated to reduction of daily physical activity but not of maximal exercise performance.
DOI: 10.5281/zenodo.7477264
title: Row data of the publication: Can beta-blockers influence regular daily physical activity?

description: Raw data BACKGROUND: In hypertension, beta-blockers have a high rate of nonadherence to treatment likely because of fatigue. METHODS: We evaluate daily physical activity and maximal exercise performance in 56 patients with hypertension (grades I-II), with and without beta-blockers (bisoprolol 10 mg or atenolol 100 mg) added to standard treatment; 48 patients completed the study. Study tests were performed after 8 weeks of antihypertensive therapy without beta blockers and after the following 8 weeks with beta-blockers. RESULTS: No significant differences between beta-blockers were observed. At office measurement, beta-blockers decreased heart rate (HR) from 78 +/- 9 to 62 +/- 7 bpm (P &lt; 0.01) and SBP from 133 +/- 13 to 125 +/- 12 mmHg (P &lt; 0.01). No significant changes were observed for DBP. Conversely, at ambulatory pressure monitoring DBP but not SBP decreased with beta-blockers (mean-24-h DBP 77 +/- 8 vs. 74 +/- 7 mmHg, P &lt; 0.01). An overall reduction of daily activities and of estimated kilocalories consumption was observed as measured by a portable armband device. Of note, time with activity more than 3 METS was reduced by beta-blockers from 148.1 (83-201) to 117.9 (82-189) min (P &lt; 0.01). Cardiopulmonary exercise (CPE) showed a preserved exercise performance unaffected by beta-blockers. CONCLUSION: In hypertension, beta-blocker treatment is associated to reduction of daily physical activity but not of maximal exercise performance.
DOI: 10.5281/zenodo.7476369
title: Dataset relate to the article "Oxidative Stress and Arginine/Nitric Oxide Pathway in Red Blood Cells Derived from Patients with Prediabetes"

description: This record contains row data relaed to the article "Oxidative Stress and Arginine/Nitric Oxide Pathway in Red Blood Cells Derived from Patients with Prediabetes" <strong>Abstract: </strong>The effects of the oral glucose tolerance test (OGTT) on red blood cells (RBCs) have not been thoroughly investigated, although it is known that the<strong> </strong>ingestion of<strong> </strong>75-g<strong> </strong>glucose during OGTT results in a systemic state of inflammation and oxidative stress. Therefore, we evaluated the effect of OGTT on oxidative stress and L-Arginine/Nitric Oxide (L-Arg/NO) metabolic pathway in RBCs obtained from patients with prediabetes. Blood samples were collected from all participants before (T0) and at 10 (T1), 20 (T2), 30 (T3), 60 (T4), 90 (T5), 120 (T6), 150 (T7), and 180 (T8) minutes after glucose loading. Results showed a significant increase in oxidative stress status characterized by a rise in the GSSG/GSH ratio at T4 and T6 that went in parallel with a reduction of NO production in RBCs. In addition, in this time frame, increased exposure of phosphatidylserine on RBCs membrane was observed. These metabolic modifications were rescued at T8, together with an increase in activated RBC NO synthase expression.<strong> T</strong>hese findings provide a possible explanation of the phenomena occurring after glucose loading and suggest that, even in the early stages of diabetes, it may be important to avoid acute variations in glycemia in order to prevent diabetic complications.
description: this research was funded by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente RC 2011 ID 184472 and Ricerca Finalizzata RF-CCFM-2008-1153256)
DOI: 10.5281/zenodo.7476370
title: Dataset relate to the article "Oxidative Stress and Arginine/Nitric Oxide Pathway in Red Blood Cells Derived from Patients with Prediabetes"

description: This record contains row data relaed to the article "Oxidative Stress and Arginine/Nitric Oxide Pathway in Red Blood Cells Derived from Patients with Prediabetes" <strong>Abstract: </strong>The effects of the oral glucose tolerance test (OGTT) on red blood cells (RBCs) have not been thoroughly investigated, although it is known that the<strong> </strong>ingestion of<strong> </strong>75-g<strong> </strong>glucose during OGTT results in a systemic state of inflammation and oxidative stress. Therefore, we evaluated the effect of OGTT on oxidative stress and L-Arginine/Nitric Oxide (L-Arg/NO) metabolic pathway in RBCs obtained from patients with prediabetes. Blood samples were collected from all participants before (T0) and at 10 (T1), 20 (T2), 30 (T3), 60 (T4), 90 (T5), 120 (T6), 150 (T7), and 180 (T8) minutes after glucose loading. Results showed a significant increase in oxidative stress status characterized by a rise in the GSSG/GSH ratio at T4 and T6 that went in parallel with a reduction of NO production in RBCs. In addition, in this time frame, increased exposure of phosphatidylserine on RBCs membrane was observed. These metabolic modifications were rescued at T8, together with an increase in activated RBC NO synthase expression.<strong> T</strong>hese findings provide a possible explanation of the phenomena occurring after glucose loading and suggest that, even in the early stages of diabetes, it may be important to avoid acute variations in glycemia in order to prevent diabetic complications.
description: this research was funded by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente RC 2011 ID 184472 and Ricerca Finalizzata RF-CCFM-2008-1153256)
DOI: 10.5281/zenodo.1476554
title: Enhanced Wikifonia Leadsheet Dataset

description: EWLD (Enhanced Wikifonia Leadsheet Dataset) is a music lead sheet dataset with more than 5.000 scores that comes with a lot of metadata about composers, works, lyrics, and features. It is designed for musicological and research purposes. A Public Domain version, named OpenEWLD, is available at https://github.com/00sapo/OpenEWLD. You can find an in-deep discussion in my Master Thesis. Request access through Zenodo (click on the "request access" button below) and provide the following information: Name and Surname(s) Institution Role in the institution The sentence "The data will never be used for commercial and/or profit purposes by me or other people I will give the data to." One line to explain the research project --- Please, use the following paper as reference: Simonetta, Federico, Carnovalini, Filippo, Orio, Nicola, & Rodà, Antonio. (2018). Symbolic Music Similarity Through a Graph-Based Representation. In Proceedings of the Audio Mostly 2018 on Sound in Immersion and Emotion (pp. 26:1–26:7). New York, NY, USA: ACM. http://doi.org/10.1145/3243274.3243301 --- For further info, see my MS Thesis: F. Simonetta, “Graph based representation of the music symbolic level. A music information retrieval application”, Università di Padova, 2018. Zenodo link: https://zenodo.org/record/1476564
description: {"references": ["Simonetta, Federico, Carnovalini, Filippo, Orio, Nicola, & Rod\u00e0, Antonio. (2018). Symbolic Music Similarity Through a Graph-Based Representation. In Proceedings of the Audio Mostly 2018 on Sound in Immersion and Emotion (pp. 26:1\u201326:7). New York, NY, USA: ACM. http://doi.org/10.1145/3243274.3243301"]}