cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16634911.v1
title: Supplementary Material for: The Exosomal MicroRNA Profile Is Responsible for the Mesenchymal Stromal Cell Transplantation-Induced Improvement of Functional Recovery after Stroke in Rats

description: <b><i>Introduction:</i></b> The mechanism through which mesenchymal stromal cells (MSCs) enhance functional recovery in experimental models of stroke remains to be elucidated. This study was carried out to determine the microRNA (miRNA) profile elicited in response to MSC transplantation after stroke. <b><i>Methods:</i></b> This was an in vivo study on the effect of MSC transplantation on the exosomal miRNA profile in a rat model of middle cerebral artery occlusion (MCAO)-induced stroke. Eighteen male Sprague-Dawley rats were subjected to MCAO surgery (model group), and half received a transplantation of MSCs (model + MSC group) isolated from rat bone marrow. A sham-operated group (Sham) was included as a control. After 7 days, the volume of the brain lesion and severity of the functional impairments were measured. Exosomes were isolated from blood plasma samples for miRNA transcriptome analysis by Illumina sequencing. <b><i>Results:</i></b> The MCAO surgery successfully induced infarcts and neurological deficits in the rats, whereas the MSC transplantation significantly repaired these impairments. Illumina sequencing identified 764 known miRNAs, including 135 that were differentially expressed in common between the model + MSC and model, model and Sham, and model + MSC and Sham groups, respectively. Gene Ontology enrichment analysis revealed that the target genes of these miRNAs were associated with biological processes relevant to learning or memory and the development of the central and peripheral nervous systems. Pathway enrichment analysis identified a cluster of miRNAs (e.g., rno-miR-19b-3p, rno-miR-204-3p, rno-miR-125a-5p, rno-miR-672-3p, and rno-miR-667-3p) to be significantly related to the Janus kinase-signal transducer and activator of transcription, mechanistic target of rapamycin, phosphoinositide 3-kinases–Akt, and insulin signaling pathways via their control of their gene targets. <b><i>Conclusion:</i></b> We confirmed that MSC transplantation repaired stroke-induced functional impairments in rats by regulating various pathways associated with nervous system protection and MSC differentiation through the deregulation of exosomal miRNAs.
DOI: 10.5281/zenodo.5512157
title: goosynthpart9

description: goosynthpart9
DOI: 10.5281/zenodo.5512156
title: goosynthpart9

description: goosynthpart9
DOI: 10.5281/zenodo.5512496
title: Wikidata Dump

description: RDF dump of wikidata produced with wdumps. <br> View on wdumper <b>entity count</b>: 0, <b>statement count</b>: 0, <b>triple count</b>: 0
DOI: 10.5281/zenodo.5512495
title: Wikidata Dump

description: RDF dump of wikidata produced with wdumps. <br> View on wdumper <b>entity count</b>: 0, <b>statement count</b>: 0, <b>triple count</b>: 0
DOI: 10.6084/m9.figshare.16634926
title: Supplementary Material for: People with Cerebral Palsy and Their Family’s Preferences about Genomics Research

description: <b><i>Introduction:</i></b> The goal of this study was to understand individuals with cerebral palsy (CP) and their family’s attitudes and preferences to genomic research, including international data sharing and biobanking. <b><i>Methods:</i></b> Individuals with CP and their family members were invited to participate in the web-based survey via email (NSW/ACT CP Register) or via posts on social media by Cerebral Palsy Alliance, CP Research Network, and CP Now. Survey responses included yes/no/unsure, multiple choices, and Likert scales. Fisher’s exact and χ<sup>2</sup> tests were used to assess if there were significant differences between subgroups. <b><i>Results:</i></b> Individuals with CP and their families (<i>n</i> = 145) were willing to participate in genomics research (68%), data sharing (82%), and biobanking efforts (75%). This willingness to participate was associated with completion of tertiary education, previous genetic testing experience, overall higher genomic awareness, and trust in international researchers. The survey respondents also expressed ongoing communication and diverse information needs regarding the use of their samples and data. Major concerns were associated with privacy and data security. <b><i>Discussion:</i></b> The success of genomic research and international data sharing efforts in CP are contingent upon broad support and recruitment. Ongoing consultation and engagement of individuals with CP and their families will facilitate trust and promote increased awareness of genomics in CP that may in turn maximize participant uptake and recruitment.
DOI: 10.6084/m9.figshare.16634926.v1
title: Supplementary Material for: People with Cerebral Palsy and Their Family’s Preferences about Genomics Research

description: <b><i>Introduction:</i></b> The goal of this study was to understand individuals with cerebral palsy (CP) and their family’s attitudes and preferences to genomic research, including international data sharing and biobanking. <b><i>Methods:</i></b> Individuals with CP and their family members were invited to participate in the web-based survey via email (NSW/ACT CP Register) or via posts on social media by Cerebral Palsy Alliance, CP Research Network, and CP Now. Survey responses included yes/no/unsure, multiple choices, and Likert scales. Fisher’s exact and χ<sup>2</sup> tests were used to assess if there were significant differences between subgroups. <b><i>Results:</i></b> Individuals with CP and their families (<i>n</i> = 145) were willing to participate in genomics research (68%), data sharing (82%), and biobanking efforts (75%). This willingness to participate was associated with completion of tertiary education, previous genetic testing experience, overall higher genomic awareness, and trust in international researchers. The survey respondents also expressed ongoing communication and diverse information needs regarding the use of their samples and data. Major concerns were associated with privacy and data security. <b><i>Discussion:</i></b> The success of genomic research and international data sharing efforts in CP are contingent upon broad support and recruitment. Ongoing consultation and engagement of individuals with CP and their families will facilitate trust and promote increased awareness of genomics in CP that may in turn maximize participant uptake and recruitment.
DOI: 10.15151/esrf-es-543588076
title: Deformation in Ni alloy

description: Ni alloy 3dxrd
DOI: 10.15151/esrf-es-514140708
title: Operando investigation of medium size, secondary zinc-air battery

description: The following proposal is aimed to provide the insight into degradation mechanism of zinc air secondary batteries and deliver experimental evidence to the existing mathematical models, extending them to simulate the practical, upscaled systems, i.e. non-symmetric, medium-to-big-size metal-air batteries. This will be achieved thanks to high resolution and ultra-high brilliance of newly established Extremely Brilliant Source (EBS) at ESRF.
DOI: 10.15151/esrf-es-542361850
title: cryo-EM studies of SARS-CoV2 polymerase, nsp12, bound to nsp7 and nsp8 co-factors and inhbited by b12.

description: The current COVID pandemic illustrates the potential of new emerging viruses and the necessity to explore the antiviral therapeutics. SARS-CoV2 nsp12 polymerase is a crucial drug target as it plays a key role in viral replication machinery. nsp12 performs the RNA dependent RNA polymerase activity, which is stimulated by its interaction with the viral cofactors nsp7 and nsp8. Though additional viral nsp subunits are likely necessary to carry out the full repertoire of replication and transcription activities, the nsp12-nsp7-nsp8 complex so far represents the minimal complex required for nucleotide polymerization. Here, we would like to determine the cryo-EM structure of this three protein complex bound to b12 inhibitor.
DOI: 10.5281/zenodo.5509219
title: Dataset of VulScope#CCS2021

description: We evaluate VulScope on 30 real-world CVEs from NVD, covering 6 popular software. For each CVE, we try to identify under-reported vulnerable versions by generating PoCs for multiple target software versions. This dataset covers 500 CVE-version pairs evaluated by VulScope, among which we use 30 of them as reference CVE-version pairs (reported by NVD as vulnerable) and the remaining 470 as target CVE-version pairs. Here, for all CVEs in the dataset, we make the inputs of VulScope open source to ease follow-up research. To obtain access to this dataset, please read our open source policy (i.e., conditions of restricted access to this repo).
DOI: 10.5281/zenodo.4954466
title: Dataset of VulScope#CCS2021

description: We evaluate VulScope on 30 real-world CVEs from NVD, covering 6 popular software. For each CVE, we try to identify under-reported vulnerable versions by generating PoCs for multiple target software versions. This dataset covers 500 CVE-version pairs evaluated by VulScope, among which we use 30 of them as reference CVE-version pairs (reported by NVD as vulnerable) and the remaining 470 as target CVE-version pairs. Here, for all CVEs in the dataset, we make the inputs of VulScope open source to ease follow-up research. To obtain access to this dataset, please read our open source policy (i.e., conditions of restricted access to this repo).
DOI: 10.6084/m9.figshare.16634935
title: Supplementary Material for: Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study

description: <b><i>Background:</i></b> In late preterm infants born in nontertiary hospitals, the occurrence of respiratory distress syndrome requires postnatal transport. This study aimed to investigate the impact of the timing of surfactant administration in late preterm infants needing postnatal transport. <b><i>Methods:</i></b> This is a retrospective study evaluating surfactant administration in late preterm infants during emergency transports by the Eastern Veneto Neonatal Emergency Transport Service between January 2005 and December 2019. The outcome measures included short-term clinical complications, stabilization time, oxygen concentration, duration of mechanical ventilation and noninvasive respiratory support, length of hospital stay, bronchopulmonary dysplasia, intraventricular hemorrhage, and sepsis. <b><i>Results:</i></b> Surfactant was administered to 155/303 neonates (51.1%) at 3 different time points: at a referring hospital (50 neonates), when the transport team arrived (25 neonates), or at a referral hospital (80 neonates). Stabilization time was longer in neonates receiving surfactant by the transport team (adjusted mean difference 17 min, 95% confidence interval, 4–29 min; <i>p</i> = 0.01). Decrease in oxygen concentrations during the transport was larger in neonates receiving surfactant at a referring hospital (adjusted mean difference −11%, 95% confidence interval, −15 to −3%; <i>p</i> = 0.01). The other outcome measures were not statistically different according to the timing of surfactant administration. <b><i>Conclusions:</i></b> In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.
DOI: 10.6084/m9.figshare.16634935.v1
title: Supplementary Material for: Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study

description: <b><i>Background:</i></b> In late preterm infants born in nontertiary hospitals, the occurrence of respiratory distress syndrome requires postnatal transport. This study aimed to investigate the impact of the timing of surfactant administration in late preterm infants needing postnatal transport. <b><i>Methods:</i></b> This is a retrospective study evaluating surfactant administration in late preterm infants during emergency transports by the Eastern Veneto Neonatal Emergency Transport Service between January 2005 and December 2019. The outcome measures included short-term clinical complications, stabilization time, oxygen concentration, duration of mechanical ventilation and noninvasive respiratory support, length of hospital stay, bronchopulmonary dysplasia, intraventricular hemorrhage, and sepsis. <b><i>Results:</i></b> Surfactant was administered to 155/303 neonates (51.1%) at 3 different time points: at a referring hospital (50 neonates), when the transport team arrived (25 neonates), or at a referral hospital (80 neonates). Stabilization time was longer in neonates receiving surfactant by the transport team (adjusted mean difference 17 min, 95% confidence interval, 4–29 min; <i>p</i> = 0.01). Decrease in oxygen concentrations during the transport was larger in neonates receiving surfactant at a referring hospital (adjusted mean difference −11%, 95% confidence interval, −15 to −3%; <i>p</i> = 0.01). The other outcome measures were not statistically different according to the timing of surfactant administration. <b><i>Conclusions:</i></b> In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.
DOI: 10.6084/m9.figshare.14721444.v7
title: Structure of PDE3A-SLFN12 and Structure-based Design for Ptent Apoptosis Inducer of Tumor Cells

description: A structurally diverse group of chemicals, including female sex hormone 17-β-estradiol (E2), a clinically used anti-platelet drug anagrelide, a natural product nauclefine, and a synthetic chemical 6-(4-(diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2<em>H</em>)-one, DNMDP, induce apoptosis by forming a complex with phosphodiesterase 3A (PDE3A) and Schlafen 12 (SLFN12). They do so by binding to the PDE3A enzymatic pocket that allows the compound-bound PDE3A to recruit and stabilize SLFN12, which in turn blocks protein translation, leading to apoptosis. We report here the high-resolution cryo-EM structure of PDE3A-SLFN12 complexes isolated from the cultured HeLa cells, which were pre-treated with either anagrelide, or nauclefine, or DNMDP. The PDE3A-SLFN12 complexes exhibit a butterfly-like shape, forming a heterotetramer with these small molecules, which are packed in a shallow pocket in the catalytic domain of PDE3A, and the resulting modified interface binds with the short helix (E552-I558) of SLFN12 through hydrophobic interactions. Based on this structural information, we designed and synthesized anagrelide analogs to enhance their interactions with SLFN12 and thus achieved superior efficacy in inducing apoptosis in cultured cells as well as tumor xenograft. Our results demonstrated that by enhancing the compound-mediated ‘glue” interaction between PDE3A and SLFN12, more potent apoptosis inducers with potential superior anti-cancer activity can be achieved.
DOI: 10.5281/zenodo.5513281
title: Post-Perovskite Phase Transition in the Pyrolitic Lowermost Mantle: Implications for Ubiquitous Occurrence of Post-Perovskite Above CMB

description: <strong>Table 1.</strong> Experimental Results
DOI: 10.5281/zenodo.5513280
title: Post-Perovskite Phase Transition in the Pyrolitic Lowermost Mantle: Implications for Ubiquitous Occurrence of Post-Perovskite Above CMB

description: <strong>Table 1.</strong> Experimental Results
DOI: 10.6084/m9.figshare.16634929
title: Early Neoproterozoic accretion at the northern margin of the Chottanagpur Gneiss Complex, eastern India- Supporting Data

description: The S1 figure includes the results of P-T pseudosection analysis of an anatectic granitoid sample at the northern margin of the Chottanagpur Gneiss Complex, Eastern India. The S2 figure is the BSE image of a petrographic thin section showing the textural relations in a mica schist sample. The S3 table consists of chemical compositions in monazites, and monazite spot ages (±2σ errors) in Ma from granitoids, anatectic gneisses and schist samples. The rock samples were collected in 2017 from areas around the town of Gaya, Bihar. Electron microprobe dating of monazites in the samples was done at the Department of Geology and Geophysics, IIT Kharagpur. The monazite dating protocol is outlined in detail in Prabhakar (2013) and Deshmukh et al. (2017). The data was generated to constrain the tectonics and timing of the accretion between the Gaya-Mahakoshal Belt and the Chottanagpur Gneiss Complex, eastern India.
DOI: 10.6084/m9.figshare.16634929.v1
title: Early Neoproterozoic accretion at the northern margin of the Chottanagpur Gneiss Complex, eastern India- Supporting Data

description: The S1 figure includes the results of P-T pseudosection analysis of an anatectic granitoid sample at the northern margin of the Chottanagpur Gneiss Complex, Eastern India. The S2 figure is the BSE image of a petrographic thin section showing the textural relations in a mica schist sample. The S3 table consists of chemical compositions in monazites, and monazite spot ages (±2σ errors) in Ma from granitoids, anatectic gneisses and schist samples. The rock samples were collected in 2017 from areas around the town of Gaya, Bihar. Electron microprobe dating of monazites in the samples was done at the Department of Geology and Geophysics, IIT Kharagpur. The monazite dating protocol is outlined in detail in Prabhakar (2013) and Deshmukh et al. (2017). The data was generated to constrain the tectonics and timing of the accretion between the Gaya-Mahakoshal Belt and the Chottanagpur Gneiss Complex, eastern India.
DOI: 10.5517/ccdc.csd.cc2524q4
title: CCDC 1998065: Experimental Crystal Structure Determination

description: Related Article: Xialiang Li, Xue-Peng Zhang, Mian Guo, Bin Lv, Kai Guo, Xiaotong Jin, Wei Zhang, Yong-Min Lee, Shunichi Fukuzumi, Wonwoo Nam, Rui Cao|2021|J.Am.Chem.Soc.|143|14613|doi:10.1021/jacs.1c05204
DOI: 10.5517/ccdc.csd.cc270w7d
title: CCDC 2056423: Experimental Crystal Structure Determination

description: Related Article: Yoshinobu Kamakura, Satoshi Fujisawa, Koki Takahashi, Hiroki Toshima, Yuka Nakatani, Hirofumi Yoshikawa, Akinori Saeki, Kazuyoshi Ogasawara, Daisuke Tanaka|2021|Inorg.Chem.|60|12691|doi:10.1021/acs.inorgchem.1c01725
DOI: 10.5517/ccdc.csd.cc27mvk9
title: CCDC 2074661: Experimental Crystal Structure Determination

description: Related Article: Tatsuo Okauchi, Akihiro Urakawa, Nagomi Tabuchi, Miten Arai, Tomoya Nakagawa, Taiga Ichimura, Hirokazu Shimooka, Mitsuru Kitamura|2021|Organometallics|40|2929|doi:10.1021/acs.organomet.1c00321
DOI: 10.5517/ccdc.csd.cc27mvnd
title: CCDC 2074664: Experimental Crystal Structure Determination

description: Related Article: Tatsuo Okauchi, Akihiro Urakawa, Nagomi Tabuchi, Miten Arai, Tomoya Nakagawa, Taiga Ichimura, Hirokazu Shimooka, Mitsuru Kitamura|2021|Organometallics|40|2929|doi:10.1021/acs.organomet.1c00321
DOI: 10.5281/zenodo.5512442
title: Phyto-toxic ozone dose (POD3IAM) calculations from EMEP MSC-W model rv4.16, 2008-2012

description: A global (1x1 degree) set of daily POD3 calculations for irrigated and non-irrigated wheat, produced with the EMEP MSC-W chemical transport model v4.16 (Simpson et al., 2012,2018, and refs therein). Data used for studies of crop damage: Mills G, Sharps K, Simpson D, et al. Ozone pollution will compromise efforts to increase global wheat production. Glob. Change Biol. 2018a;24:3560–3574. https://doi.org/10.1111/gcb.14157 (note: this paper used an earlier model version though, v4.8) Mills G, Sharps K, Simpson D, et al. Closing the global ozone yield gap: Quantification and cobenefits for multistress tolerance. Glob. Change Biol. 2018b;24:4869–4893. https://doi.org/10.1111/gcb.14381 (this paper used v4.16) See Mills et al (2018a) for model setup and evaluation. EMEP model documentation can be found in: Simpson, D., Benedictow, A., Berge, H., Bergström, R., Emberson, L. D., Fagerli, H., ... Wind, P. (2012). The EMEP MSC‐W chemical transport model -- technical description. Atmos. Chem. Phys., 12, 7825–7865. https://doi.org/10.5194/acp-12-7825-2012 Simpson, D., Wind, P., Bergström, R., Gauss, M., Tsyro, S. and Valdebenito, A, Updates to the EMEP/MSC-W model, 2017--2018, In: Transboundary particulate matter, photo-oxidants, acidifying and eutrophying components. EMEP Status Report 1/2018, 109-116, Norwegian Meteorological Institute, available from www.emep.int, 2018 See www.emep.int for further information on the EMEP MSC-W model.
description: Files are netcdf, compressed with the "xz" algorithm (available on linux and windows).
DOI: 10.5281/zenodo.5512441
title: Phyto-toxic ozone dose (POD3IAM) calculations from EMEP MSC-W model rv4.16, 2008-2012

description: A global (1x1 degree) set of daily POD3 calculations for irrigated and non-irrigated wheat, produced with the EMEP MSC-W chemical transport model v4.16 (Simpson et al., 2012,2018, and refs therein). Data used for studies of crop damage: Mills G, Sharps K, Simpson D, et al. Ozone pollution will compromise efforts to increase global wheat production. Glob. Change Biol. 2018a;24:3560–3574. https://doi.org/10.1111/gcb.14157 (note: this paper used an earlier model version though, v4.8) Mills G, Sharps K, Simpson D, et al. Closing the global ozone yield gap: Quantification and cobenefits for multistress tolerance. Glob. Change Biol. 2018b;24:4869–4893. https://doi.org/10.1111/gcb.14381 (this paper used v4.16) See Mills et al (2018a) for model setup and evaluation. EMEP model documentation can be found in: Simpson, D., Benedictow, A., Berge, H., Bergström, R., Emberson, L. D., Fagerli, H., ... Wind, P. (2012). The EMEP MSC‐W chemical transport model -- technical description. Atmos. Chem. Phys., 12, 7825–7865. https://doi.org/10.5194/acp-12-7825-2012 Simpson, D., Wind, P., Bergström, R., Gauss, M., Tsyro, S. and Valdebenito, A, Updates to the EMEP/MSC-W model, 2017--2018, In: Transboundary particulate matter, photo-oxidants, acidifying and eutrophying components. EMEP Status Report 1/2018, 109-116, Norwegian Meteorological Institute, available from www.emep.int, 2018 See www.emep.int for further information on the EMEP MSC-W model.
description: Files are netcdf, compressed with the "xz" algorithm (available on linux and windows).
DOI: 10.24396/ordar-69
title: Conditions of chondrule formation in ordinary chondrites

description: Data from the paper: Conditions of chondrule formation in ordinary chondrites
DOI: 10.14284/509
title: Acoustic telemetry data for Diplodus sargus, Sarpa salpa, Sepia officinalis and Solea senegalensis in the Arrábida Marine Park (Portugal)

description: This dataset contains up to three years of acoustic telemetry data of Diplodus sargus (n=20), Sarpa salpa (n=2), Sepia officinalis (n=6) and Solea senegalensis (n=22) in the Arrábida Marine Park (Portugal).
description: This is an acoustic telemetry dataset containing animal (fish and cephalopod) tracking data collected for the project/study PhD DAbecasis, using VEMCO tags (V7 and V9) and receivers (VR2 and VR2W). A total of 20 white seabream (Diplodus sargus), 22 Senegalese sole (Solea senegalensis), 2 salema (Sarpa salpa) and 6 cuttlefish (Sepia officinalis) were captured, tagged, and released between 2010 and 2012 in the Arrábida Marine Park (Portugal). The main objective was to study the spatial ecology of these species and to better understand the protection provided by the marine protected area to these important species.
DOI: 10.5519/qd.x6jjjthb
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (122 records)