cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc13zb8p
title: CCDC 1042042: Experimental Crystal Structure Determination

description: Related Article: Xin Chen, Ai-Quan Jia, Rufei Ye, Hua-Tian Shi, Qian-Feng Zhang|2015|J.Coord.Chem.|68|2835|doi:10.1080/00958972.2015.1061658
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13zb9q
title: CCDC 1042043: Experimental Crystal Structure Determination

description: Related Article: Xin Chen, Ai-Quan Jia, Rufei Ye, Hua-Tian Shi, Qian-Feng Zhang|2015|J.Coord.Chem.|68|2835|doi:10.1080/00958972.2015.1061658
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13zbbr
title: CCDC 1042044: Experimental Crystal Structure Determination

description: Related Article: Xin Chen, Ai-Quan Jia, Rufei Ye, Hua-Tian Shi, Qian-Feng Zhang|2015|J.Coord.Chem.|68|2835|doi:10.1080/00958972.2015.1061658
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13zbcs
title: CCDC 1042045: Experimental Crystal Structure Determination

description: Related Article: Xin Chen, Ai-Quan Jia, Rufei Ye, Hua-Tian Shi, Qian-Feng Zhang|2015|J.Coord.Chem.|68|2835|doi:10.1080/00958972.2015.1061658
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf58
title: CCDC 1058469: Experimental Crystal Structure Determination

description: Related Article: Chih-Yu Huang, Li-Hsun Chen, Hsuan-Yu Huang, Feng-Sheng Kao, Yun-Ta Lee, Manikandan Selvaraju, Chung-Ming Sun, Hueih-Min Chen|2015|RSC Advances|5|50801|doi:10.1039/C5RA06095H
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc13xk1m
title: CCDC 1040330: Experimental Crystal Structure Determination

description: Related Article: P. Sharma, K. N. Subbulakshmi, B. Narayana, B. K. Sarojini, R. Kant|2016|Crystallogr.Rep.|61|230|doi:10.1134/S106377451602022X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc14jffj
title: CCDC 1058477: Experimental Crystal Structure Determination

description: Related Article: Zongwei Yang, Yuping Wang, Junhong Zhou, Hongzhen Li, Hui Huang, Fude Nie|2014|Propellants,Explos.,Pyrotech.|39|9|doi:10.1002/prep.201300086
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf7b
title: CCDC 1058471: Experimental Crystal Structure Determination

description: Related Article: Viacheslav A. Petrov, Rebecca Dooley, Alexander A. Marchione, Will Marshall|2016|J.Fluorine Chem.|182|12|doi:10.1016/j.jfluchem.2015.11.006
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc14jf8c
title: CCDC 1058472: Experimental Crystal Structure Determination

description: Related Article: Viacheslav A. Petrov, Rebecca Dooley, Alexander A. Marchione, Will Marshall|2016|J.Fluorine Chem.|182|12|doi:10.1016/j.jfluchem.2015.11.006
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jfbf
title: CCDC 1058474: Experimental Crystal Structure Determination

description: Related Article: Viacheslav A. Petrov, Rebecca Dooley, Alexander A. Marchione, Will Marshall|2016|J.Fluorine Chem.|182|12|doi:10.1016/j.jfluchem.2015.11.006
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc14jf9d
title: CCDC 1058473: Experimental Crystal Structure Determination

description: Related Article: Viacheslav A. Petrov, Rebecca Dooley, Alexander A. Marchione, Will Marshall|2016|J.Fluorine Chem.|182|12|doi:10.1016/j.jfluchem.2015.11.006
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jdy0
title: CCDC 1058462: Experimental Crystal Structure Determination

description: Related Article: Min Chen, Zhi-Tang Huang, Qi-Yu Zheng|2015|Org.Biomol.Chem.|13|8812|doi:10.1039/C5OB01301A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf03
title: CCDC 1058464: Experimental Crystal Structure Determination

description: Related Article: Elisabeth Nagaradja, Ghenia Bentabed-Ababsa, Mathieu Scalabrini, Floris Chevallier, Stéphanie Philippot, Stéphane Fontanay, Raphaël E. Duval, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Florence Mongin|2015|Bioorg.Med.Chem.|23|6355|doi:10.1016/j.bmc.2015.08.031
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf14
title: CCDC 1058465: Experimental Crystal Structure Determination

description: Related Article: Elisabeth Nagaradja, Ghenia Bentabed-Ababsa, Mathieu Scalabrini, Floris Chevallier, Stéphanie Philippot, Stéphane Fontanay, Raphaël E. Duval, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Florence Mongin|2015|Bioorg.Med.Chem.|23|6355|doi:10.1016/j.bmc.2015.08.031
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf25
title: CCDC 1058466: Experimental Crystal Structure Determination

description: Related Article: Elisabeth Nagaradja, Ghenia Bentabed-Ababsa, Mathieu Scalabrini, Floris Chevallier, Stéphanie Philippot, Stéphane Fontanay, Raphaël E. Duval, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Florence Mongin|2015|Bioorg.Med.Chem.|23|6355|doi:10.1016/j.bmc.2015.08.031
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30424888
title: Supplementary Material for: Chromosomal Instability in Mouse Induced Pluripotent Stem Cells: Insights into X and Y Aneuploidies

description: Introduction:
Induced pluripotent stem (iPS) cells share key features with embryonic stem (ES) cells, including similar limitations such as the accumulation of (epi)genetic and genomic alterations. However, sex chromosome instability in mouse iPS cells remains poorly understood. This retrospective study aims to investigate this phenomenon by analyzing mouse iPS cell clones. Specifically, we examine whether factors such as passage number, cell sex, founder cell type, or reprogramming method influence the presence or absence of sex chromosome abnormalities.
Methods:
Sex chromosome stability was evaluated in 26 independent male and female mouse iPS cell clones using standard karyotyping techniques. Additionally, we analyzed an artificially generated XXY iPS cell model, in which an extra X chromosome was introduced into a normal XY cell line. Statistical analyses were conducted on the karyotyping results and correlated with both continuous variables (e.g., passage number) and categorical variables (e.g., cell sex, founder cell type, and reprogramming method).
Results: 
Female iPS cell clones displayed significantly higher levels of sex chromosome instability compared to their male counterparts, regardless of the founder cell type or reprogramming strategy. A similar pattern of X chromosome instability was also observed in the XXY iPS cell model.
Conclusion:
Our findings demonstrate that sex chromosome instability occurs in mouse iPS cells, as previously reported in mouse ES cells, suggesting a conserved phenomenon across pluripotent stem cell types. Importantly, the presence of multiple X chromosomes in the pluripotent state appears to contribute to this instability. Further studies are required to elucidate the underlying molecular mechanisms.
DOI: 10.6084/m9.figshare.30424888.v1
title: Supplementary Material for: Chromosomal Instability in Mouse Induced Pluripotent Stem Cells: Insights into X and Y Aneuploidies

description: Introduction:
Induced pluripotent stem (iPS) cells share key features with embryonic stem (ES) cells, including similar limitations such as the accumulation of (epi)genetic and genomic alterations. However, sex chromosome instability in mouse iPS cells remains poorly understood. This retrospective study aims to investigate this phenomenon by analyzing mouse iPS cell clones. Specifically, we examine whether factors such as passage number, cell sex, founder cell type, or reprogramming method influence the presence or absence of sex chromosome abnormalities.
Methods:
Sex chromosome stability was evaluated in 26 independent male and female mouse iPS cell clones using standard karyotyping techniques. Additionally, we analyzed an artificially generated XXY iPS cell model, in which an extra X chromosome was introduced into a normal XY cell line. Statistical analyses were conducted on the karyotyping results and correlated with both continuous variables (e.g., passage number) and categorical variables (e.g., cell sex, founder cell type, and reprogramming method).
Results: 
Female iPS cell clones displayed significantly higher levels of sex chromosome instability compared to their male counterparts, regardless of the founder cell type or reprogramming strategy. A similar pattern of X chromosome instability was also observed in the XXY iPS cell model.
Conclusion:
Our findings demonstrate that sex chromosome instability occurs in mouse iPS cells, as previously reported in mouse ES cells, suggesting a conserved phenomenon across pluripotent stem cell types. Importantly, the presence of multiple X chromosomes in the pluripotent state appears to contribute to this instability. Further studies are required to elucidate the underlying molecular mechanisms.
DOI: 10.5517/cc14jf36
title: CCDC 1058467: Experimental Crystal Structure Determination

description: Related Article: Elisabeth Nagaradja, Ghenia Bentabed-Ababsa, Mathieu Scalabrini, Floris Chevallier, Stéphanie Philippot, Stéphane Fontanay, Raphaël E. Duval, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Florence Mongin|2015|Bioorg.Med.Chem.|23|6355|doi:10.1016/j.bmc.2015.08.031
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf47
title: CCDC 1058468: Experimental Crystal Structure Determination

description: Related Article: Elisabeth Nagaradja, Ghenia Bentabed-Ababsa, Mathieu Scalabrini, Floris Chevallier, Stéphanie Philippot, Stéphane Fontanay, Raphaël E. Duval, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Florence Mongin|2015|Bioorg.Med.Chem.|23|6355|doi:10.1016/j.bmc.2015.08.031
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jf69
title: CCDC 1058470: Experimental Crystal Structure Determination

description: Related Article: Hongyun Liao|2015|CSD Communication|||
description: Related Article: Pengfei Zhang, Hongyun Liao, Hanghang Wang, Xiaofang Li, Fanzhi Yang, Shaowen Zhang|2017|Organometallics|36|2446|doi:10.1021/acs.organomet.7b00322
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30424891
title: Supplementary Material for: Ribociclib-Induced Hepatitis – A Case Report of Possible Autoimmune Hepatotoxicity

description: Background: Hormone receptor positive breast cancer is the most common subtype, accounting for approximately two thirds of all breast cancer cases. In the metastatic setting, first line treatment is comprised of endocrine therapy and a cyclin-dependent kinase 4 and 6 inhibitor. Ribociclib is the most used agent and has the highest risk of hepatotoxicity among the three currently available cyclin-dependent kinase 4 and 6 inhibitors.
Case Presentation: We present a case of a 59-year-old post-menopausal female with metastatic hormone receptor positive breast cancer who started treatment with fulvestrant and ribociclib after progression on anastrozole. After the third cycle, she developed grade 3 transaminitis. Ribociclib was held and after no improvement in 28 days, she was treated with a six-day course of prednisone 1 mg/kg, with significant improvement in her liver enzymes. Rechallenge with a lower dose of ribociclib (200 mg) was attempted, however she again developed grade 3 transaminitis. This again required treatment with a short course of corticosteroids. Following normalization of her liver enzymes, she was rechallenged with abemaciclib with no recurrent hepatotoxicity. 
Conclusion: Ribociclib hepatotoxicity can be successfully treated with withdrawal of the medication and a short course of corticosteroids if liver enzymes do not improve following a 28-day withdrawal, highlighting a potential immune-mediated mechanism. Additionally, rechallenge with another cyclin-dependent kinase 4 and 6 inhibitor is a safe and effective strategy that should be considered.
DOI: 10.5517/cc145gj9
title: CCDC 1047940: Experimental Crystal Structure Determination

description: Related Article: Ivan Nemec, Radovan Herchel, Ingrid Svoboda, Roman Boča, Zdeněk Trávníček|2015|Dalton Trans.|44|9551|doi:10.1039/C5DT00600G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc145gmd
title: CCDC 1047943: Experimental Crystal Structure Determination

description: Related Article: Ivan Nemec, Radovan Herchel, Ingrid Svoboda, Roman Boča, Zdeněk Trávníček|2015|Dalton Trans.|44|9551|doi:10.1039/C5DT00600G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30424891.v1
title: Supplementary Material for: Ribociclib-Induced Hepatitis – A Case Report of Possible Autoimmune Hepatotoxicity

description: Background: Hormone receptor positive breast cancer is the most common subtype, accounting for approximately two thirds of all breast cancer cases. In the metastatic setting, first line treatment is comprised of endocrine therapy and a cyclin-dependent kinase 4 and 6 inhibitor. Ribociclib is the most used agent and has the highest risk of hepatotoxicity among the three currently available cyclin-dependent kinase 4 and 6 inhibitors.
Case Presentation: We present a case of a 59-year-old post-menopausal female with metastatic hormone receptor positive breast cancer who started treatment with fulvestrant and ribociclib after progression on anastrozole. After the third cycle, she developed grade 3 transaminitis. Ribociclib was held and after no improvement in 28 days, she was treated with a six-day course of prednisone 1 mg/kg, with significant improvement in her liver enzymes. Rechallenge with a lower dose of ribociclib (200 mg) was attempted, however she again developed grade 3 transaminitis. This again required treatment with a short course of corticosteroids. Following normalization of her liver enzymes, she was rechallenged with abemaciclib with no recurrent hepatotoxicity. 
Conclusion: Ribociclib hepatotoxicity can be successfully treated with withdrawal of the medication and a short course of corticosteroids if liver enzymes do not improve following a 28-day withdrawal, highlighting a potential immune-mediated mechanism. Additionally, rechallenge with another cyclin-dependent kinase 4 and 6 inhibitor is a safe and effective strategy that should be considered.
DOI: 10.5517/cc14jfjm
title: CCDC 1058480: Experimental Crystal Structure Determination

description: Related Article: Sabrina Pietsch, Ursula Paul,  Ian A. Cade, Michael J. Ingleson, Udo Radius, Todd B. Marder|2015|Chem.-Eur.J.|21|9018|doi:10.1002/chem.201501498
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jfkn
title: CCDC 1058481: Experimental Crystal Structure Determination

description: Related Article: Jonathan O. Bauer, Carsten Strohmann|2015|J.Organomet.Chem.|797|52|doi:10.1016/j.jorganchem.2015.07.026
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jflp
title: CCDC 1058482: Experimental Crystal Structure Determination

description: Related Article: Jonathan O. Bauer, Carsten Strohmann|2015|J.Organomet.Chem.|797|52|doi:10.1016/j.jorganchem.2015.07.026
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jfmq
title: CCDC 1058483: Experimental Crystal Structure Determination

description: Related Article: Elangovan Sindhuja,  Rengan Ramesh|2014|Tetrahedron Lett.|55|5504|doi:10.1016/j.tetlet.2014.08.035
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc14jfvy
title: CCDC 1058490: Experimental Crystal Structure Determination

description: Related Article: Teh-Chang Chou,  Jing-Kai Huang,  Sushilkumar S. Bahekar,  Ju-Hsiou Liao|2014|Tetrahedron|70|8361|doi:10.1016/j.tet.2014.08.071
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.