cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7587251
title: Additional file 2: of An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning

description: Driver Program. (TXT 10 kb)
DOI: 10.6084/m9.figshare.7587251.v1
title: Additional file 2: of An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning

description: Driver Program. (TXT 10 kb)
DOI: 10.7284/119538
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise FK151121 using a Hawaii UHDAS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7587257.v1
title: Additional file 3: of An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning

description: Stabilization Data (aggregated) for all parameter sets. (CSV 731 kb)
DOI: 10.6084/m9.figshare.7587242
title: Additional file 1: of An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning

description: Netlogo Model. (TXT 28 kb)
DOI: 10.6084/m9.figshare.7587239
title: Additional file 3: of Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children

description: Data collected from FFQ. (XLSX 775 kb)
DOI: 10.7284/119536
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise FK151121 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7587233
title: Additional file 1: of Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children

description: Food Frequency Questionnaire (FFQ) template used. (XLS 48 kb)
DOI: 10.6084/m9.figshare.7587239.v1
title: Additional file 3: of Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children

description: Data collected from FFQ. (XLSX 775 kb)
DOI: 10.6084/m9.figshare.7587242.v1
title: Additional file 1: of An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning

description: Netlogo Model. (TXT 28 kb)
DOI: 10.7284/119537
title: Expendable Probe data collected during research cruise FK151121 using a Turo Quoll instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7587233.v1
title: Additional file 1: of Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children

description: Food Frequency Questionnaire (FFQ) template used. (XLS 48 kb)
DOI: 10.7284/119539
title: Fluorometer data collected during research cruise FK151121 using a WET Labs ECO-FLNTU instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119535
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK151121 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119534
title: Gyrocompass data collected during research cruise FK151121 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119544
title: INS (Inertial Navigation System) data collected during research cruise FK151121 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/119542
title: Meteorological Station data collected during research cruise FK151121 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586675
title: Data, Analysis scripts and materials for: Almeida. D. (2014). Subliminal wh-islands in Brazilian Portuguese and the consequences for syntactic theory. Revista da ABRALIN, 13(2), 55-91.

description: Data, Analysis scripts and materials for the paper:<br>Almeida. D. (2014). Subliminal wh-islands in Brazilian Portuguese and the consequences for syntactic theory. Revista da ABRALIN, 13(2), 55-91.
DOI: 10.7284/119540
title: Multibeam Echosounder data collected during research cruise FK151121 using a Kongsberg EM302 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586675.v1
title: Data, Analysis scripts and materials for: Almeida. D. (2014). Subliminal wh-islands in Brazilian Portuguese and the consequences for syntactic theory. Revista da ABRALIN, 13(2), 55-91.

description: Data, Analysis scripts and materials for the paper:<br>Almeida. D. (2014). Subliminal wh-islands in Brazilian Portuguese and the consequences for syntactic theory. Revista da ABRALIN, 13(2), 55-91.
DOI: 10.6084/m9.figshare.7586417
title: Molecular modelling of HPV E6 protein reveal new potential inhibitors against high-risk Human Papillomavirus: Supporting Information

description: <b>Abstract:</b> High-risk strains of human papillomavirus (HPV) have been identified as the etiologic agent of some anogenital tract, head, and neck cancers. Although prophylactic HPV vaccines have been approved; it is still necessary a drug-based treatment against the infection and its oncogenic effects. The E6 oncoprotein is one of the most studied therapeutic targets of HPV, it has been identified as a key factor in cell immortalization and tumor progression in HPV-positive cells. E6 can promote the degradation of p53, a tumor suppressor protein, through the interaction with the cellular ubiquitin ligase E6AP. Therefore, preventing the formation of the E6-E6AP complex is one of the main strategies to inhibit the viability and proliferation of infected cells. Herein, <b>we propose an <i>in silico</i> pipeline to identify small-molecule inhibitors of the E6-E6AP interaction</b>. Virtual screening was carried out by predicting the ADME properties of the molecules and performing ensemble-based docking simulations to E6 protein followed by binding free energy estimation through MM/PB(GB)SA methods. Finally, the top-three compounds were selected, and their stability in the E6 docked complex and their effect in the inhibition of the E6-E6AP interaction was corroborated by molecular dynamics simulation. Therefore, this pipeline and the identified molecules represent a new starting point in the development of anti-HPV drugs.<br>This<b> fileset </b>contains raw data from molecular dynamics simulations of HPV-16 E6 protein, including initial files and backbone trajectories. Also includes the initial compound library, ADME properties predictions, molecular docking results and hit compounds in mol2 format.<br><br>
DOI: 10.6084/m9.figshare.7586417.v1
title: Molecular modelling of HPV E6 protein reveal new potential inhibitors against high-risk Human Papillomavirus: Supporting Information

description: <b>Abstract:</b> High-risk strains of human papillomavirus (HPV) have been identified as the etiologic agent of some anogenital tract, head, and neck cancers. Although prophylactic HPV vaccines have been approved; it is still necessary a drug-based treatment against the infection and its oncogenic effects. The E6 oncoprotein is one of the most studied therapeutic targets of HPV, it has been identified as a key factor in cell immortalization and tumor progression in HPV-positive cells. E6 can promote the degradation of p53, a tumor suppressor protein, through the interaction with the cellular ubiquitin ligase E6AP. Therefore, preventing the formation of the E6-E6AP complex is one of the main strategies to inhibit the viability and proliferation of infected cells. Herein, <b>we propose an <i>in silico</i> pipeline to identify small-molecule inhibitors of the E6-E6AP interaction</b>. Virtual screening was carried out by predicting the ADME properties of the molecules and performing ensemble-based docking simulations to E6 protein followed by binding free energy estimation through MM/PB(GB)SA methods. Finally, the top-three compounds were selected, and their stability in the E6 docked complex and their effect in the inhibition of the E6-E6AP interaction was corroborated by molecular dynamics simulation. Therefore, this pipeline and the identified molecules represent a new starting point in the development of anti-HPV drugs.<br>This<b> fileset </b>contains raw data from molecular dynamics simulations of HPV-16 E6 protein, including initial files and backbone trajectories. Also includes the initial compound library, ADME properties predictions, molecular docking results and hit compounds in mol2 format.<br><br>
DOI: 10.7284/119541
title: Multibeam Echosounder data collected during research cruise FK151121 using a Kongsberg EM710 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586351
title: CCDB_1018.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586408.v1
title: Repeat annotation and Non-coding RNA annotation of Platysternon megacephalum

description: Repeat annotation and Non-coding RNA annotation of Platysternon megacephalum.
DOI: 10.6084/m9.figshare.7586330
title: CCDB_1017.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586351.v1
title: CCDB_1018.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.7284/119543
title: SSV (Sound Speed Velocimeter) data collected during research cruise FK151121 using a Valeport MiniSVS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586330.v1
title: CCDB_1017.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.7284/121440
title: TSG (Thermosalinograph) data collected during research cruise FK151121 using a Sea-Bird SBE-45 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586267
title: CCDB_1015.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586282
title: CCDB_1016.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.7284/120988
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise FK151221 using a Hawaii UHDAS instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586243
title: CCDB_1014.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586267.v1
title: CCDB_1015.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586282.v1
title: CCDB_1016.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586240
title: CCDB_1013.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.7284/120989
title: Fluorometer data collected during research cruise FK151221 using a WET Labs ECO-FLNTU instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586231
title: CCDB_1012.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586243.v1
title: CCDB_1014.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586231.v1
title: CCDB_1012.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.6084/m9.figshare.7586240.v1
title: CCDB_1013.jpg

description: Optical section series through a protoplasmic astrocyte in rat hippocampal area CA1 intracellulaly injected Lucifer Yellow and imaged with confocal microscopy
DOI: 10.7284/120987
title: GNSS (Global Navigation Satellite System) data collected during research cruise FK151221 using a C&C C-Nav 3050 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586105
title: U-net weights for T2/Flair whole tumor segmentation

description: Whole tumor segmentation u-net model using T2 and flair modalities<br>
DOI: 10.6084/m9.figshare.7586153
title: Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase

description: Nuclear pores elarge in cells infected with herpes simplex virus 1 (HSV-1). Capsids, which are assembled in the nucleus, may gain access to the cytosol through impared nuclear pores in addition to bdudding at the inner nuclear membrane. In the absence of the HSV-1 Us3 kinase, nuclear membranes are produced in excess and impairement of nuclear pores is reduced in number and size.<br>
DOI: 10.7284/120986
title: Gyrocompass data collected during research cruise FK151221 using a Raytheon STD 22 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586099
title: Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: A systematic review and meta-analysis

description: <b>Objectives:</b> Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT through a systematic review. <b>Methods:</b> Four therapeutic approaches for APAT, including antiplatelet agents, glucocorticoids, splenectomy and thrombopoietin receptor agonists, were selected. Clinical trials evaluating therapeutic outcomes including the remission, complications, mortality and relapse, were searched in MEDLINE, EMBASE and CENTRAL from the inception dates to 28 November 2016. A meta-analysis was performed to calculate risk ratios (RRs) and 95% confidence intervals (CIs) using random-effects models. <b>Results:</b> Out of 1407 papers, eight controlled clinical trials were included. In patients with APAT, the remission rates were higher in patients on glucocorticoids (RR 8.33 [95% CI 3.07–22.6]) or splenectomy (RR 8.37 [95% CI 1.61–43.7]) than in patients without those treatments. There was no significant association between glucocorticoids and thrombosis (RR 1.57 [95% CI, 0.17–14.9]) or between splenectomy and hemorrhage (RR 0.17 [95% CI 0.02–1.28]). The extracted data of mortality and relapse rate were not available for synthesis. <b>Conclusion:</b> Glucocorticoids or splenectomy seemed suitable therapeutic approaches for APAT.
DOI: 10.7284/120994
title: INS (Inertial Navigation System) data collected during research cruise FK151221 using a Kongsberg Seapath 320 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7586090
title: Matlab code to collect x,y animal coordinates from behavioral video

description: This simple custom computer code written in Matlab 2017a reads a behavioral video file, and at one second intervals pauses and allows the user to register x,y coordinates of the animal by clicking one the center of animal.The x,y coordinates of corners of the test apparatus are obtained in order to estimate the pixel to cm ratio of estimation of distance ambulated (DistAmb) and percent of time spent ambulating (TiempoAmb). Code finalizes saving the obtained data.<br>
DOI: 10.6084/m9.figshare.7586099.v1
title: Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: A systematic review and meta-analysis

description: <b>Objectives:</b> Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT through a systematic review. <b>Methods:</b> Four therapeutic approaches for APAT, including antiplatelet agents, glucocorticoids, splenectomy and thrombopoietin receptor agonists, were selected. Clinical trials evaluating therapeutic outcomes including the remission, complications, mortality and relapse, were searched in MEDLINE, EMBASE and CENTRAL from the inception dates to 28 November 2016. A meta-analysis was performed to calculate risk ratios (RRs) and 95% confidence intervals (CIs) using random-effects models. <b>Results:</b> Out of 1407 papers, eight controlled clinical trials were included. In patients with APAT, the remission rates were higher in patients on glucocorticoids (RR 8.33 [95% CI 3.07–22.6]) or splenectomy (RR 8.37 [95% CI 1.61–43.7]) than in patients without those treatments. There was no significant association between glucocorticoids and thrombosis (RR 1.57 [95% CI, 0.17–14.9]) or between splenectomy and hemorrhage (RR 0.17 [95% CI 0.02–1.28]). The extracted data of mortality and relapse rate were not available for synthesis. <b>Conclusion:</b> Glucocorticoids or splenectomy seemed suitable therapeutic approaches for APAT.
DOI: 10.6084/m9.figshare.7586033
title: Morphometric data and locomotor and social behavior data of male Japanese quail during in a Social Interaction test, in birds reared in an enriched or a standard environment.

description: <b>Environmental enrichment (EE) protocol</b>During the EE in the brood boxes (8-28 days old), 3 different sets of enrichments were rotated between boxes every 7 days. After reallocation in home cages at 28 days of age, EE was applied in 3 periods with different enrichment sets. Within each period, EE home cages received weekly one of the three enrichment sets in a random order in such a manner that all EE animals were exposed to the 3 enrichment sets. The replacement of the enrichment items was done on a fixed day and time every week, and during this procedure all the animals were removed from the box and placed in a basket. Control animals underwent the same manipulation procedure.<br><b>Social Interaction Test</b> was performed between 118 and 130 days of age. This test is described in detail in Caliva et al (2017, Pout. Sci) including a figure with the schematic representation of the test procedure. Briefly, the SI test consists in encounters between an unfamiliar test adult male and a PC stimulus adult male, in the presence of the test bird’s female cagemate (audience). First, the test male and it’s female cagemate were placed in a central compartment separated by an opaque partition from a PC stimulus male. After 2 min, the test male and the PC stimulus male, remained in the same compartment, while the female cagemate was placed in a nearby compartment at one side of the apparatus, and used as a social audience. Immediately after, the central opaque partition was removed and the test and PC stimulus birds were allowed to interact. Direct interaction lasted a maximum of 10 min. However, if during the interaction a quail received more than 5 consecutive aggressive pecks, showed a clear and continued escaping (retrieval) behavior, and/or showed any sign of physical damage, the interaction was immediately interrupted. A video-camera was positioned 1 m above the apparatus and connected to a computer that allowed constant monitoring and recording during the test while out of the sight of the birds. Using ANY-maze the following aggressive behaviors were recorded: pecks, grabs, mounts, cloacal contacts, threats, chase, and attack with claws. Herein, when grabs, mounts or cloacal contacts were performed by one male towards another male, they were considered as aggressive behaviors. Males that performed more than 5 aggressiveness behaviors were considered aggressive (Ag), and males that did not perform any aggressive behavior towards PC opponent were considered non-aggressive (nonAg).Males exposed to the experimental apparatus without the presence of an opponent (testCON) and non-manipulated males that always remained in the home cage (Naive) with their cagemate were used as control groups.<br>
DOI: 10.7284/120992
title: Meteorological Station data collected during research cruise FK151221 using a Gill MetPak Pro instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition