cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6448448.v1
title: The influence of clinical, environmental, and socioeconomic factors on five-year patient survival after kidney transplantation

description: ABSTRACT Introduction: The risk of death after kidney transplant is associated with the age of the recipient, presence of comorbidities, socioeconomic status, local environmental characteristics and access to health care. Objective: To investigate the causes and risk factors associated with death during the first 5 years after kidney transplantation. Methods: This was a single-center, retrospective, matched case-control study. Results: Using a consecutive cohort of 1,873 kidney transplant recipients from January 1st 2007 to December 31st 2009, there were 162 deaths (case group), corresponding to 5-year patient survival of 91.4%. Of these deaths, 25% occurred during the first 3 months after transplant. The most prevalent cause of death was infectious (53%) followed by cardiovascular (24%). Risk factors associated with death were history of diabetes, dialysis type and time, unemployment, delayed graft function, number of visits to center, number of hospitalizations, and duration of hospital stay. After multivariate analysis, only time on dialysis, number of visits to center, and days in hospital were still associated with death. Patients who died had a non-significant higher number of treated acute rejection episodes (38% vs. 29%, p = 0.078), higher mean number of adverse events per patient (5.1 ± 3.8 vs. 3.8 ± 2.9, p = 0.194), and lower mean eGFR at 3 months (50.8 ± 25.1 vs. 56.7 ± 20.7, p = 0.137) and 48 months (45.9 ± 23.8 vs. 58.5 ± 20.2, p = 0.368). Conclusion: This analysis confirmed that in this population, infection is the leading cause of mortality over the first 5 years after kidney transplantation. Several demographic and socioeconomic risk factors were associated with death, most of which are not readily modifiable.
DOI: 10.6084/m9.figshare.6448445
title: The enigma of aluminum deposition in bone tissue from a patient with chronic kidney disease: a case report

description: ABSTRACT About four decades ago, the relationship between dialysis-dementia and aluminum (Al) began to be established. The restriction of drugs containing Al and improvements on water quality used for dialysis resulted in the clinical disappearance of Al intoxication. However, high prevalence of Al deposition in bone tissue from Brazilian dialysis patients is still being detected. Through the case report of a patient on hemodialysis (HD) for one year, presenting significant Al deposition in bone tissue, we speculated if this problem is not being underestimated. We used extensive investigation to identify potential sources of Al exposure with a careful review of medication history and water quality controls. Al concentration was measured by different methods, including mass spectrometry, in poly-electrolyte concentrate solutions and solution for peritoneal dialysis, in an attempt to elucidate the possible sources of contamination. The objective of this case report is to alert the medical community about a potential high prevalence of Al deposition in bone tissue and to discuss the possible sources of contamination in patients with chronic kidney disease (CKD).
DOI: 10.6084/m9.figshare.6448445.v1
title: The enigma of aluminum deposition in bone tissue from a patient with chronic kidney disease: a case report

description: ABSTRACT About four decades ago, the relationship between dialysis-dementia and aluminum (Al) began to be established. The restriction of drugs containing Al and improvements on water quality used for dialysis resulted in the clinical disappearance of Al intoxication. However, high prevalence of Al deposition in bone tissue from Brazilian dialysis patients is still being detected. Through the case report of a patient on hemodialysis (HD) for one year, presenting significant Al deposition in bone tissue, we speculated if this problem is not being underestimated. We used extensive investigation to identify potential sources of Al exposure with a careful review of medication history and water quality controls. Al concentration was measured by different methods, including mass spectrometry, in poly-electrolyte concentrate solutions and solution for peritoneal dialysis, in an attempt to elucidate the possible sources of contamination. The objective of this case report is to alert the medical community about a potential high prevalence of Al deposition in bone tissue and to discuss the possible sources of contamination in patients with chronic kidney disease (CKD).
DOI: 10.6084/m9.figshare.6448442
title: Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives

description: ABSTRACT This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. The successes really started in 1993 with the first formulation patented under the trade name Photofrin, which was immediately approved in several countries to treat certain types of cancer. Photofrin is still used although certain negative features soon became well known. That has motivated the search for better new photosensitizers. Several ones were developed, evaluated and a few of them had clinical approval. This group includes porphyrin derivatives and pro-drugs (aminolevulinic acid and its alkyl esters). Oncological, dermatological and ophthalmic applications are now taking place for the benefit of mankind. The second part of this review is related with the work carried out in Aveiro at the authors University on the synthesis and biological evaluation of several potential PDT photosensitizers. Not only new synthetic methodologies mainly for porphyrins and chlorins were developed but also other related macrocycles of the phthalocyanine and corrole types have entered in the same “pipeline”. In vivo and in vitro biological evaluations also took place under interdisciplinary studies.
DOI: 10.6084/m9.figshare.6448442.v1
title: Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives

description: ABSTRACT This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. The successes really started in 1993 with the first formulation patented under the trade name Photofrin, which was immediately approved in several countries to treat certain types of cancer. Photofrin is still used although certain negative features soon became well known. That has motivated the search for better new photosensitizers. Several ones were developed, evaluated and a few of them had clinical approval. This group includes porphyrin derivatives and pro-drugs (aminolevulinic acid and its alkyl esters). Oncological, dermatological and ophthalmic applications are now taking place for the benefit of mankind. The second part of this review is related with the work carried out in Aveiro at the authors University on the synthesis and biological evaluation of several potential PDT photosensitizers. Not only new synthetic methodologies mainly for porphyrins and chlorins were developed but also other related macrocycles of the phthalocyanine and corrole types have entered in the same “pipeline”. In vivo and in vitro biological evaluations also took place under interdisciplinary studies.
DOI: 10.6084/m9.figshare.6448439
title: CD77 levels over enzyme replacement treatment in Fabry Disease Family (V269M)

description: ABSTRACT Introduction: Fabry disease (FD) is a disorder caused by mutations in the gene encoding for lysosomal enzyme α-galactosidase A (α-GAL). Reduced α-GAL activity leads to progressive accumulation of globotriaosylceramide (Gb3), also known as CD77. The recent report of increased expression of CD77 in blood cells of patients with FD indicated that this molecule can be used as a potential marker for monitoring enzyme replacement therapy (ERT). Objective: The purpose of this study was to evaluate the CD77 levels throughout ERT in FD patients (V269M mutation). Methods: We evaluated the fluctuations in PBMC (peripheral blood mononuclear cell) membrane CD77 expression in FD patients undergoing ERT and correlated these levels with those observed in different cell types. Results: A greater CD77 expression was found in phagocytes of patients compared to controls at baseline. Interestingly, the variability in CD77 levels is larger in patients at baseline (340 - 1619 MIF) and after 12 months of ERT (240 - 530 MIF) compared with the control group (131 - 331 MFI). Furthermore, by analyzing the levels of CD77 in phagocytes from patients throughout ERT, we found a constant decrease in CD77 levels. Conclusion: The increased CD77 levels in the phagocytes of Fabry carriers together with the decrease in CD77 levels throughout ERT suggest that measuring CD77 levels in phagocytes is a promising tool for monitoring the response to ERT in FD.
DOI: 10.6084/m9.figshare.6448439.v1
title: CD77 levels over enzyme replacement treatment in Fabry Disease Family (V269M)

description: ABSTRACT Introduction: Fabry disease (FD) is a disorder caused by mutations in the gene encoding for lysosomal enzyme α-galactosidase A (α-GAL). Reduced α-GAL activity leads to progressive accumulation of globotriaosylceramide (Gb3), also known as CD77. The recent report of increased expression of CD77 in blood cells of patients with FD indicated that this molecule can be used as a potential marker for monitoring enzyme replacement therapy (ERT). Objective: The purpose of this study was to evaluate the CD77 levels throughout ERT in FD patients (V269M mutation). Methods: We evaluated the fluctuations in PBMC (peripheral blood mononuclear cell) membrane CD77 expression in FD patients undergoing ERT and correlated these levels with those observed in different cell types. Results: A greater CD77 expression was found in phagocytes of patients compared to controls at baseline. Interestingly, the variability in CD77 levels is larger in patients at baseline (340 - 1619 MIF) and after 12 months of ERT (240 - 530 MIF) compared with the control group (131 - 331 MFI). Furthermore, by analyzing the levels of CD77 in phagocytes from patients throughout ERT, we found a constant decrease in CD77 levels. Conclusion: The increased CD77 levels in the phagocytes of Fabry carriers together with the decrease in CD77 levels throughout ERT suggest that measuring CD77 levels in phagocytes is a promising tool for monitoring the response to ERT in FD.
DOI: 10.6084/m9.figshare.6448436
title: Expenses of the Brazilian Public Healthcare System with chronic kidney disease

description: ABSTRACT Introduction: The prevalence of chronic kidney disease (CKD) is increasing worldwide, with costs that can be impeditive. Objective: To establish the expenses of the Brazilian Public Healthcare System (SUS), with hospitalizations due to CKD and related diseases; evaluating expenses with renal replacement therapy (RRT). Methods: We have assessed the values paid by the SUS in the triennium 2013-2015, for estimating annual expenses with CKD treatment and hospitalization, associated diseases, and exams. Results: There was an increase in hospitalization by all causes in Brazil during this triennium. CKD and associated diseases corresponded to 1.82% and 5.79% of hospitalizations due to all causes in Brazil, and 2.87% and 10.10% of all expenses, respectively. Kidney grafts from deceased donors corresponded to 76% of hospitalizations and 80% of expenses with transplantation. There was a decrease in transplantation from living donors. There was an increase in the number of exams of 11.94% and of 10.95% in the expenses. There was a decrease in the number of procedures and expenses in intermittent peritoneal dialysis (IPD) and related procedures; but other procedures increased. Hemodialysis (3 weekly sessions) corresponded to 95.96% of procedures and 96.07% of expenses with dialysis in general. Conclusion: Renal diseases and some of the main related diseases corresponded to 12.97% of the expenses in the triennium 2013-2015, and RRT to more than 5% of the SUS expenses with medium and high complexity healthcare. Such high expenses determine great concerns on the future maintenance of treatment for stage-5 CKD in Brazil and countries in similar or worse conditions of development.
DOI: 10.6084/m9.figshare.6448436.v1
title: Expenses of the Brazilian Public Healthcare System with chronic kidney disease

description: ABSTRACT Introduction: The prevalence of chronic kidney disease (CKD) is increasing worldwide, with costs that can be impeditive. Objective: To establish the expenses of the Brazilian Public Healthcare System (SUS), with hospitalizations due to CKD and related diseases; evaluating expenses with renal replacement therapy (RRT). Methods: We have assessed the values paid by the SUS in the triennium 2013-2015, for estimating annual expenses with CKD treatment and hospitalization, associated diseases, and exams. Results: There was an increase in hospitalization by all causes in Brazil during this triennium. CKD and associated diseases corresponded to 1.82% and 5.79% of hospitalizations due to all causes in Brazil, and 2.87% and 10.10% of all expenses, respectively. Kidney grafts from deceased donors corresponded to 76% of hospitalizations and 80% of expenses with transplantation. There was a decrease in transplantation from living donors. There was an increase in the number of exams of 11.94% and of 10.95% in the expenses. There was a decrease in the number of procedures and expenses in intermittent peritoneal dialysis (IPD) and related procedures; but other procedures increased. Hemodialysis (3 weekly sessions) corresponded to 95.96% of procedures and 96.07% of expenses with dialysis in general. Conclusion: Renal diseases and some of the main related diseases corresponded to 12.97% of the expenses in the triennium 2013-2015, and RRT to more than 5% of the SUS expenses with medium and high complexity healthcare. Such high expenses determine great concerns on the future maintenance of treatment for stage-5 CKD in Brazil and countries in similar or worse conditions of development.
DOI: 10.6084/m9.figshare.6448430
title: Durability of Soil-Cement Blocks with the Incorporation of Limestone Residues from the Processing of Marble

description: The great environmental impact caused by mineral production has forced mining and ornamental stone industries to acquire new concepts and technical solutions in order to develop eco-friendly and sustainable activities. In this context, this work aims to study the durability of soil-cement block with the incorporation of limestone residues from the processing of marble as an ornamental stone. Specimens were prepared with 30, 40 and 50 vol% of residues added to the soil-cement mixture and analyzed for their physical, chemical and mineralogical properties. After the curing period, the specimens were subjected to mechanical analysis and the established experimental program showed that the addition of residues in the mixture becomes feasible for the preparation of soil-cement blocks, exhibiting improved results when compare to a reference block without residues.
DOI: 10.6084/m9.figshare.6448430.v1
title: Durability of Soil-Cement Blocks with the Incorporation of Limestone Residues from the Processing of Marble

description: The great environmental impact caused by mineral production has forced mining and ornamental stone industries to acquire new concepts and technical solutions in order to develop eco-friendly and sustainable activities. In this context, this work aims to study the durability of soil-cement block with the incorporation of limestone residues from the processing of marble as an ornamental stone. Specimens were prepared with 30, 40 and 50 vol% of residues added to the soil-cement mixture and analyzed for their physical, chemical and mineralogical properties. After the curing period, the specimens were subjected to mechanical analysis and the established experimental program showed that the addition of residues in the mixture becomes feasible for the preparation of soil-cement blocks, exhibiting improved results when compare to a reference block without residues.
DOI: 10.6084/m9.figshare.6448427
title: Evaluation of early age cracking in rendering mortars with polypropylene fibers

description: Abstract The incorporation of fibers in concrete produces an improvement in the characteristics of the material as observed in different studies. In order to obtain the same good results, fibers are added to rendering mortars to reduce some of their drawbacks. However, this type of mortar has some specific characteristics, such as hydrated-lime utilization or higher air, which is not usual in concrete. Thus, this study aims to evaluate the potential of polypropylene fibers to reduce early age cracking caused by restrained shrinkage in rendering mortars. Two types of mortars were used to verify possible differences in the way they responded to the introduction of fiber. The influence of the fiber content was also investigated. Mortars were evaluated in fresh state, and mechanical behaviors were measured at several ages. The restrained shrinkage cracking was followed for 21 days using the ring test method. The use of polypropylene fibers leads a smaller value of total crack width and a delay of the first crack. Also, the elastic modulus shows a higher correlation with the mortars crack width. Both parameters were successfully used to predict the mortars crack width. The ring test method may be a suitable test method to evaluate the capacity of fibers to control the crack formation in rendering mortars.
DOI: 10.6084/m9.figshare.6448427.v1
title: Evaluation of early age cracking in rendering mortars with polypropylene fibers

description: Abstract The incorporation of fibers in concrete produces an improvement in the characteristics of the material as observed in different studies. In order to obtain the same good results, fibers are added to rendering mortars to reduce some of their drawbacks. However, this type of mortar has some specific characteristics, such as hydrated-lime utilization or higher air, which is not usual in concrete. Thus, this study aims to evaluate the potential of polypropylene fibers to reduce early age cracking caused by restrained shrinkage in rendering mortars. Two types of mortars were used to verify possible differences in the way they responded to the introduction of fiber. The influence of the fiber content was also investigated. Mortars were evaluated in fresh state, and mechanical behaviors were measured at several ages. The restrained shrinkage cracking was followed for 21 days using the ring test method. The use of polypropylene fibers leads a smaller value of total crack width and a delay of the first crack. Also, the elastic modulus shows a higher correlation with the mortars crack width. Both parameters were successfully used to predict the mortars crack width. The ring test method may be a suitable test method to evaluate the capacity of fibers to control the crack formation in rendering mortars.
DOI: 10.6084/m9.figshare.6448409
title: Helicobacter pylori infection in family members of patients with gastroduodenal symptoms. A cross-sectional analytical study

description: ABSTRACT BACKGROUND: Primary Helicobacter pylori (H. pylori) infection is acquired predominantly in childhood in the family setting. We aimed to investigate the presence of intrafamilial concurrent H. pylori infection. DESIGN AND SETTING: Cross-sectional analytical study with a control group, conducted in a tertiary care hospital. METHODS: Fifty adult patients with gastroduodenal symptoms who underwent gastroscopy (index parents), their spouses and their children were enrolled in the study. Blood samples were collected from all of the study subjects to test for immunoglobulin G (IgG) antibody response. H. pylori antigen was investigated in the stool specimens of children only. RESULTS: The participants were divided into two groups: Group 1 consisted of the 40 patients in whom H. pylori infection was demonstrated via endoscopy, their spouses and their children. Group 2 included the remaining 10 patients who underwent endoscopy revealing negative results for H. pylori, their spouses and their children. IgG antibodies were present in all of the index parents, 95% of their spouses and 93% of their children in group 1; 13 of the children (9%) were also positive for H. pylori stool antigen (HpSA). However, IgG antibodies were present in only 2 of the 10 index parents in group 2. One of their spouses and one of their children had a positive antibody response. All of their children had negative stool antigen test results. CONCLUSION: H. pylori infections exhibit intrafamilial clustering. Parental infection, age ≥ years and having three or more siblings are the major risk factors for H. pylori infection in children.
DOI: 10.6084/m9.figshare.6448409.v1
title: Helicobacter pylori infection in family members of patients with gastroduodenal symptoms. A cross-sectional analytical study

description: ABSTRACT BACKGROUND: Primary Helicobacter pylori (H. pylori) infection is acquired predominantly in childhood in the family setting. We aimed to investigate the presence of intrafamilial concurrent H. pylori infection. DESIGN AND SETTING: Cross-sectional analytical study with a control group, conducted in a tertiary care hospital. METHODS: Fifty adult patients with gastroduodenal symptoms who underwent gastroscopy (index parents), their spouses and their children were enrolled in the study. Blood samples were collected from all of the study subjects to test for immunoglobulin G (IgG) antibody response. H. pylori antigen was investigated in the stool specimens of children only. RESULTS: The participants were divided into two groups: Group 1 consisted of the 40 patients in whom H. pylori infection was demonstrated via endoscopy, their spouses and their children. Group 2 included the remaining 10 patients who underwent endoscopy revealing negative results for H. pylori, their spouses and their children. IgG antibodies were present in all of the index parents, 95% of their spouses and 93% of their children in group 1; 13 of the children (9%) were also positive for H. pylori stool antigen (HpSA). However, IgG antibodies were present in only 2 of the 10 index parents in group 2. One of their spouses and one of their children had a positive antibody response. All of their children had negative stool antigen test results. CONCLUSION: H. pylori infections exhibit intrafamilial clustering. Parental infection, age ≥ years and having three or more siblings are the major risk factors for H. pylori infection in children.
DOI: 10.6084/m9.figshare.6448406
title: WHY DO I CHOOSE TO DO A “LICENCIATURA IN CHEMISTRY” COURSE? UNESP FRESHMAN PROFILE AND MOTIVATIONS

description: The present work aims to investigate the profile and motivation that led students to enroll in the undergraduate chemistry courses of the four São Paulo State University campuses. Case studies were carried out at each of the campuses and a comparative study was carried out in order to outline the theme in question. The quantitative data was analyzed by descriptive statistics and the qualitative data was analyzed by Content Analysis. It was found that the majority of the students are female aged between 17 and 19 years and came from public schools; they do not have jobs, and they are at an intermediate socioeconomic level. The vast majority of students chose the undergraduate degree in chemistry because of their interest in the large field of knowledge, along with the reputation and prestige of the university. It has also been identified that the graduates are led to teaching careers for essentially intrinsic motivations based on altruistic values; however, the majority does not choose to pursue a career in basic education. Faced with the scenario of possible “teacher blackout” in High Schools, these findings claim an urgent public educational policy that promotes an effective valuation of the teaching profession in Brazil.