cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24145131
title: Supplementary Material for: Irisin ameliorated skeletal muscle atrophy by inhibiting fatty acid oxidation and pyroptosis induced by palmitic acid in chronic kidney disease

description: Introduction:Protein-energy waste (PEW) is a common complication in patients with chronic kidney disease (CKD), among which skeletal muscle atrophy is one of the most important clinical features of PEW. Pyroptosis is a type of proinflammatory programmed cell death associated with skeletal muscle disease. Irisin, as a novel myokine, has attracted extensive attention for its protective role in the complications associated with CKD, but its role in muscle atrophy in CKD is unclear.Methods:Palmitic acid (PA) induced muscular atrophy was evaluated by a reduction in C2C12 myotube diameter. Muscle atrophy model was established in male C57BL/6J mice treated with 0.2% adenine for 4 weeks and then fed a 45% high-fat diet.BUN and Cr levels ,body and muscle weight, and muscle histology were assessed. The expression of carnitine palmitoyltransferase 1A (CPT1A) and pyroptosis-related protein was analysed by western blots or immunohistochemistry. The release of IL-1β was detected by ELISA.Results:In this study, we showed that PA induced muscular atrophy and manifested as a reduction in C2C12 myotube diameter. During this process PA can also induce pyroptosis, as shown by the upregulation of NLRP3, cleaved Caspase1 and GSDMD-N expression and the increased IL-1β release and PI-positive cell rate. Inhibition of Caspase1 or NLRP3 attenuated PA-induced pyroptosis and myotube atrophy in C2C12 cells. Importantly, Irisin treatment significantly ameliorated PA-induced skeletal muscle pyroptosis and atrophy. In terms of mechanism, PA upregulated CPT1A, a key enzyme of fatty acid oxidation(FAO), and Irisin attenuated this effect, which was consistent with Etomoxir (CPT1A inhibitor) treatment. Moreover, Irisin improved skeletal muscle atrophy and pyroptosis in adenine-induced mice by regulating FAO. Conclusion: our study firstly verifies that pyroptosis is a novel mechanism of skeletal muscle atrophy in CKD. Irisin ameliorated skeletal muscle atrophy by inhibiting FAO and pyroptosis in CKD, and Irisin may be developed as a potential therapeutic agent for the treatment of muscle wasting in CKD patients.
DOI: 10.6084/m9.figshare.24145131.v1
title: Supplementary Material for: Irisin ameliorated skeletal muscle atrophy by inhibiting fatty acid oxidation and pyroptosis induced by palmitic acid in chronic kidney disease

description: Introduction:Protein-energy waste (PEW) is a common complication in patients with chronic kidney disease (CKD), among which skeletal muscle atrophy is one of the most important clinical features of PEW. Pyroptosis is a type of proinflammatory programmed cell death associated with skeletal muscle disease. Irisin, as a novel myokine, has attracted extensive attention for its protective role in the complications associated with CKD, but its role in muscle atrophy in CKD is unclear.Methods:Palmitic acid (PA) induced muscular atrophy was evaluated by a reduction in C2C12 myotube diameter. Muscle atrophy model was established in male C57BL/6J mice treated with 0.2% adenine for 4 weeks and then fed a 45% high-fat diet.BUN and Cr levels ,body and muscle weight, and muscle histology were assessed. The expression of carnitine palmitoyltransferase 1A (CPT1A) and pyroptosis-related protein was analysed by western blots or immunohistochemistry. The release of IL-1β was detected by ELISA.Results:In this study, we showed that PA induced muscular atrophy and manifested as a reduction in C2C12 myotube diameter. During this process PA can also induce pyroptosis, as shown by the upregulation of NLRP3, cleaved Caspase1 and GSDMD-N expression and the increased IL-1β release and PI-positive cell rate. Inhibition of Caspase1 or NLRP3 attenuated PA-induced pyroptosis and myotube atrophy in C2C12 cells. Importantly, Irisin treatment significantly ameliorated PA-induced skeletal muscle pyroptosis and atrophy. In terms of mechanism, PA upregulated CPT1A, a key enzyme of fatty acid oxidation(FAO), and Irisin attenuated this effect, which was consistent with Etomoxir (CPT1A inhibitor) treatment. Moreover, Irisin improved skeletal muscle atrophy and pyroptosis in adenine-induced mice by regulating FAO. Conclusion: our study firstly verifies that pyroptosis is a novel mechanism of skeletal muscle atrophy in CKD. Irisin ameliorated skeletal muscle atrophy by inhibiting FAO and pyroptosis in CKD, and Irisin may be developed as a potential therapeutic agent for the treatment of muscle wasting in CKD patients.
DOI: 10.17632/3gchg9sxc2.1
title: Urdu Consumer Demand Analysis Dataset

description: This dataset consists of 2931 rows and 5 columns, making it a valuable resource for research in the domain of sentiment analysis, language processing, and market demand analysis, with a specific focus on comments written in the Urdu language. The dataset is structured as follows:

Usernames: This column contains usernames or identifiers associated with individuals who have provided comments in Urdu.

Comment: In this column, you will find comments written in the Urdu language. These comments cover a wide range of topics, including user experiences, opinions, and feedback related to various products and services.

Gender: This column captures the gender information of the users who left comments. Gender data can be instrumental in conducting gender-based analysis or understanding the perspectives of different user groups within the Urdu-speaking community.

Brand (Laptop Brand): This column specifies the laptop brand or product that is the subject of the user comments written in Urdu. It helps categorize comments by brand, allowing for brand-specific analysis within the context of the Urdu-speaking audience.

Label: The "Label" column provides labels or categories associated with the Urdu comments. These labels represent sentiment scores (e.g., positive (1), negative(0), neutral(2)).

With this dataset containing usernames, Urdu language comments, gender information, laptop brand references, and associated labels, it serves as a comprehensive resource for research focused on sentiment analysis, market demand analysis, and linguistic studies within the Urdu-speaking community. Researchers can use this dataset to gain insights into user opinions, preferences, and language patterns in the context of product reviews and market analysis.
DOI: 10.5281/zenodo.8347087
title: Overtrust 3D dataset - Part I

description: Overtrust 3D dataset - Part I
DOI: 10.5281/zenodo.8347086
title: Overtrust 3D dataset - Part I

description: Overtrust 3D dataset - Part I
DOI: 10.17632/r6r8t9wtrz.1
title: FACTORES ASOCIADOS A DESENCADENANTES Y EVENTOS ADVERSOS EN PEDIATRÍA

description: RESUMO
Introdução: verificar os fatores associados aos triggers e eventos adversos na internação pediátrica. Material e Método: pesquisa transversal embasada na metodologia do Institute for Healthcare Improvement (IHI), por meio da aplicação do Paediatric Trigger Tool (PTT) a uma amostra (n=194) de prontuários de pacientes pediátricos de um hospital do Centro-Oeste do Brasil. Foi realizada análise estatística descritiva, inferencial e regressão de Poisson. Resultados: mais da metade (n=107; 55,15%) dos pacientes apresentou pelo menos um trigger na internação. Foram identificados 204 triggers/gatilhos, com maior ocorrência de queda de hemoglobina/hematócrito (9,80%), queda de saturação de oxigênio (9,80%) e aumento de marcadores de funções renais (9,20%). Do total de gatilhos, 64 (31,37%) eventos adversos foram confirmados, os quais foram classificados majoritariamente como dano temporário com necessidade de suporte ao paciente (65,62%). O tempo de internação (p-valor=0,004) e o caráter da internação (p-valor<0,001) foram variáveis associadas à ocorrência de triggers. Caráter de internação e admissões provenientes de outras instituições foram preditores na ocorrência de triggers e eventos adversos. Conclusões: internações prolongadas e crianças admitidas via transferência merecem atenção a triggers e/ou eventos adversos concretizados.
DOI: 10.17632/2dvtw8cyhx.1
title: GuardCell_Images

description: 3D Guard Cell Segmentation Model and Dataset
DOI: 10.17632/6w84hgr7w2.1
title: TAK1 is an essential kinase for STING trafficking,Ma et al.

description: The translocation of stimulator of interferon genes (STING) from the endoplasmic reticulum (ER) to the ER–Golgi intermediate compartment (ERGIC) enables its activation. However, the mechanism underlying the regulation of STING exiting from the ER remains elusive. Here, we found that STING induces the activation of transforming growth factor beta-activated kinase 1 (TAK1) prior to STING trafficking in a TAK1 binding protein 1 (TAB1)-dependent manner. Intriguingly, activated TAK1 directly mediates STING phosphorylation on serine 355, which facilitates its interaction with STING ER exit protein (STEEP) and thereby promotes its oligomerization and translocation to the ERGIC for subsequent activation. Importantly, activation of TAK1 by monophosphoryl lipid A, a TLR4 agonist, boosts cGAMP-induced antitumor immunity dependent on STING phosphorylation in a mouse allograft tumor model. Taken together, TAK1 was identified as a checkpoint for STING activation by promoting its trafficking, providing a basis for combinatory tumor immunotherapy and intervention in STING-related diseases.
DOI: 10.17632/sd7xt2khnc.1
title: RSEI_Geodetector_data

description: RSEI geodetector data for the Lanxi urban agglomeration for 2000, 2010, and 2019
DOI: 10.17632/463zxfknwv.1
title: Toilet effluent separation and brown water treatment: survey and initial feasibility testing in Mexico.

description: Table S2: Results of survey on toilet usage in Mexico
The survey results on toilet usage in Mexico contain inquiries aimed at collecting data on diverse aspects, such as toilet paper usage, the use of disinfectants, pharmaceuticals consumption, the volume of water consumed per flush, and their willingness to consider toilet modifications and effluent separation.
DOI: 10.17632/8jc6hdgv5h.1
title: Population-based mortality in Hidradenitis Suppurativa

description: To systematically quantify the magnitude of mortality risk in patients with Hidradenitis Suppurativa (HS) and identify characteristics associated with mortality among patients with HS, a PRISMA flow diagram, Funnel plot, Forest plot and two tables were created as supplemental figures to be auxiliary to our systematic review and meta-analysis.
DOI: 10.17632/2djzdjvn96.1
title: Supplemental Material for Robust Detection of Lead-Lag Relationships in Lagged Multi-Factor Models

description: The supplemental material includes the equity, ETF, and futures data sets' performance metrics for the entire grid - rescaled to target volatility.
DOI: 10.17632/2djzdjvn96.2
title: Supplemental Material for Robust Detection of Lead-Lag Relationships in Lagged Multi-Factor Models

description: The supplemental material includes the equity, ETF, and futures data sets' performance metrics for the entire grid - rescaled to target volatility.
DOI: 10.17632/2djzdjvn96.3
title: Supplemental Material for Robust Detection of Lead-Lag Relationships in Lagged Multi-Factor Models

description: The supplemental material includes the equity, ETF, and futures data sets' performance metrics for the entire grid - rescaled to target volatility.
DOI: 10.17632/2djzdjvn96.4
title: Supplemental Material: Robust Detection of Lead-Lag Relationships in Lagged Multi-Factor Models

description: The supplemental material includes the equity, ETF, and futures data sets' performance metrics for the entire grid - rescaled to target volatility.
DOI: 10.17632/wpszpcftg2.1
title: Supplemental Material: Dynamic Time Warping for Lead-Lag Relationships in Lagged Multi-Factor Models

description: The supplemental material includes the equity, ETF, and futures data sets' performance metrics for the entire grid - rescaled to target volatility.
DOI: 10.17632/75jfpmbx23.1
title: The data set off Emotional Intelligence, Perceived Organizational Politics, and Organizational Outcomes

description: This data set is the result of analysis of Emotional Intelligence, Perceived Organizational Politics, and Organizational Outcomes from 237 regional work unit (SKPD) Civil Servants in North Maluku Province, Ternate City, Tidore Islands City, and North Halmahera Regency. There are five variables in this data set, namely Emotional Intelligence, Perceived Organizational Politics, Job Satisfaction, Job Involvement and organizational citizenship behavior.
DOI: 10.17632/vdg456mxg9.1
title: Supplementary data

description: Supplementary methods for the paper "Genetics-informed new causal proteins in atopic dermatitis pathogenesis and treatment"
DOI: 10.17632/w25d3j7gtw.1
title: IDENTIFICATION OF CLAY MINERALS IN THE SOIL USING ATTERBERG LIMIT PARAMETERS  

description: Montmorillonite clay is a problematic soil for both geotechnical and pavement engineers. Therefore, identifying the presence of the expansive montmorillonite clay mineral within the soil matrix using a simple and inexpensive method is of paramount importance. This paper presents a simple method of identifying the primary clay minerals, namely kaolinite, illite, and montmorillonite, in the soil matrix using Atterberg limits parameters, namely plasticity index, plastic limit, and slope of the fall cone curve (defined as 20/LL). The proposed methods can be used as a preliminary indicator method of identifying the presence of expansive clay minerals within the soil matrix before carrying out an expensive definitive method of identifying clay minerals, such as XRD.
DOI: 10.17632/nk34hbd6bv.1
title: Tourism GDP and Okun's misery index: Data for Mexico 

description: These data have been used to study the relationship between tourism GDP and Okun's misery index. I provide the data to build the misery index (unemployment and inflation), an excel document presenting the misery index, the dummy variables utilized in the ARDL and NARDL, tourism GDP (volume index) and an EViews file with the ARDL, NARDL and Toda-Yamamoto test results. The NARDL was estimated using the NARDL EViews add-in.
DOI: 10.17632/2rj8ss5mpn.1
title: Impact of Climate Change on Green Roof Energy Performance in Oceanic Climates: A Simulation Dataset (2022-2050)

description: This dataset comprises two distinct components. The first section encompasses climate data adapted for climate change scenarios derived from the HadCM3 GCM A2 ensemble dataset. It includes essential variables such as Dry Bulb Temperature (DBT), Dew Point Temperature (DPT), Relative Humidity (RH), Atmospheric Pressure, Extraterrestrial Horizontal Radiation (ExtHoRad), Extraterrestrial Direct Radiation (ExtDiRad), Horizontal Infrared Radiation (HoInfRad), Global Horizontal Radiation (GlHoRad), Direct Normal Radiation (DirNoRad), Diffuse Horizontal Radiation (DifHoRad), Global Horizontal Illuminance (GlHoIll), Direct Normal Illuminance (DirNoIll), Diffuse Horizontal Illuminance (DifHoIll), Zenithal Luminance (ZenLum), Wind Direction (WindDir), Wind Speed (WindSp), Total Sky Cover (TotSkyCo), Opaque Sky Cover (OpSkyCo), Visibility (Visibili), Ceiling Height (Ceiling), Precipitable Water Overhead (PWO), Precipitable Water Column (PWC), Precipitation (Prec), Aerosol Optical Depth (AerOptD), Snow Depth (SnowD), and the Date of the Last Snowfall (LastSnow). These datasets are presented in Excel, including raw data, line charts, and boxplots. The second part of the dataset presents the results of simulations assessing the thermal performance of green roofs under two scenarios: the present scenario in 2022 and a future climate change projection for 2050. These simulations were conducted using the Design Builder software. This dataset is also provided in Excel format, featuring raw data, line charts, and boxplots. It compares conventional bare roofs and green roofs in distinct climate areas, specifically Auckland, Christchurch, and Wellington. This dataset's primary focus is on the year 2050, providing valuable insights into how climate change is expected to impact the energy performance of green roofs within oceanic climates.
DOI: 10.17632/mnxd3xs8jk.1
title: Exploring the cortical hemodynamic variability of four weeks iTBS on a healthy participant: a case study_dataset

description: Raw data of the case study
DOI: 10.17632/5v8ngcgh7m.1
title: SGML Balance Sheets

description: Daishin Securities is a top 10 Korean broker-dealer with its fingers in a number of other businesses (real estate, asset management, savings bank among others).

There’s not a lot to say about the business - it’s exactly what you’d expect from a family-run Korean broker/financial conglomerate.  It is conservatively run and does not earn its cost of capital.  It generally makes net income of between KRW100bln and 125bln (and rising slowly over time) on equity of KRW2.7trln (KRW2.5trl tangible).  Daishin has not lost money since 2002.

Daishin has 3 share classes: Common, 1st Preferred, and 2nd Preferred.  Daishin has repurchased very substantial portions of each.  Frustratingly, Bloomberg does not adjust the market cap for the repurchased shares and they seemingly cannot be persuaded to do so.  Further, Daishin’s two preferred share issues, which can most simply be thought of as non-voting common shares are excluded from Bloomberg’s market cap calculation. In reality, there are ~66m shares outstanding.

In calculating Net Income Blomberg (at a minimum) subtracts preferred dividends despite the fact that the preferred shares participate fully in the earnings of the business and pro-rata in its dissolution/sale.

With that in mind here are the valuation metrics with appropriate adjustments for the economic reality:

Note: Preferred shares with tickers ending in “5” are entitled to the common dividend plus 1% of “par” value which is almost always KRW5,000 (thus 1% being an additional KRW50).  Other preferred issues are generally just entitled to the common dividend.

Most importantly, the Company is paying out the bulk of its earnings in dividends providing a nearly 10% yield.  In addition, the Company routinely buys back stock (principally the common) so there is additional “current return” benefit (i.e. your valuation-static return is close to the earnings yield than the RoE).  In general, I peg the current return (dividends + buybacks) at ~12% (on average - some years they buy back ~5% of the stock, others none) with a further ~1% return from retained earnings.

In the intermediate term, the Company is trading ~30-40% cheap vs. its historic dividend yield (though, to be fair, the payout has risen so some discount makes sense - though not this large given the crummy RoE and thus return on retained earnings) so there may be some upside to that ~12% annual return over the coming quarters/years.

Longer-term, the brokerage business is arguably sub-scale and a possible acquisition target (past sales of brokers have gone off at a premium to book).  That said, I don’t foresee a sale anytime soon as a 42 year old third generation family member recently took over as Chairman.
DOI: 10.17632/hssv66g4kb.1
title: Burn Study Data

description: "Excel MERMAID master data sheet" encodes all CBC data
"IL-6_iNOS_nNOS PCR" and "Murine burn site PCR" files encode PCR data
"Uncharacterized protein matches" and "protein literature and raw data proteins" encode proteomic data
DOI: 10.17632/hssv66g4kb.2
title: Burn Study Data

description: "Excel MERMAID master data sheet" encodes all CBC data, PCR data, and raw proteomic data
DOI: 10.17632/hssv66g4kb.3
title: Burn Study Dataset

description: "Excel MERMAID master data sheet" encodes all CBC data, PCR data, and raw proteomic data
DOI: 10.17632/hssv66g4kb.4
title: Burn Study Dataset 3.0

description: "Excel MERMAID master data sheet" encodes all CBC data, PCR data, and raw proteomic data
DOI: 10.17632/d7633hpsh8.1
title: A dataset of social network and operational performance of tourism businesses in Vietnam: The mediating role of resource access

description: The outbreak of Covid-19 severely impacted the operational performance of businesses in the tourism industry. Many firms have gone bankrupt and dissolved. Therefore, managers’ social networks are to access external support resources to overcome the crisis, keeping extremely crucial importance. Based on social network theory, this data’s purpose was to shed light on the impact of social networks on operational performance through the mediating role of access to resources. The study used the Partial Least Squares Structural Equation Modeling (PLS-SEM) method with a sample size of 212 managers of tourism businesses in Vietnam. The results showed that Government agency ties and Business partner ties positively and significantly related to operational performance. Additionally, the study’s dataset explored the mediating role of resource access between the social network (Government agency ties and Business partner ties) and operational performance. The results have practical significance for managers in building social networks to increase the ability to access support resources in coping with the crisis of COVID-19.
DOI: 10.17632/m92x2c2ft8.1
title: Ethiopian Indigineous Medicinal Plant Species Dataset

description: This dataset provides a comprehensive overview of Ethiopian Indigenous Medicinal Plant. The dataset is collected from gullele botanical garden in the period of October 2022-April 2023.
DOI: 10.17632/m92x2c2ft8.2
title: Ethiopian Indigenous Medicinal Plant Species Dataset

description: This dataset provides a comprehensive overview of Ethiopian Indigenous Medicinal Plant. The dataset is collected from gullele botanical garden in the period of October 2022-April 2023.
DOI: 10.17632/jjh9c9nvz2.1
title: MicroSwimmer_DesignFile

description: Design file(CAD,STL) of micro Swimmer robotics
DOI: 10.17632/rhdc3hmwcy.1
title: Do cows see the forest or the trees?

description: Data sets, videos and supplementary material (methods description) for the article: 
Neave HW, Rault J-L, Bateson M, Jensen EH and Jensen MB (2023) Do cows see the forest or the trees? A preliminary investigation of attentional scope as a potential indicator of emotional state in dairy cows housed with their calves. Front. Vet. Sci. 10:1257055. doi: 10.3389/fvets.2023.1257055
DOI: 10.17632/w5rsm63v98.1
title: Experiment 1 & 2 data

description: Experiment 1, a self-paced sentence-by-sentence reading experiment, utilizing (i) Empathy locus antecedent vs. (ii) Non-empathy locus antecedent and (i) Repeated-name Subject anaphor, (ii) Repeated-name Topic anaphor, vs. (iii) Null pronoun anaphor, investigated whether it detects RNP (Repeated Name Penalty);
Experiment 2, a self-paced sentence-by-sentence reading experiment, utilizing (i) Empathy locus antecedent vs. (ii) Non-empathy locus antecedent and (i) Overt-pronoun Subject anaphor, (ii) Overt-pronoun Topic anaphor, vs. (iii) Null pronoun anaphor, investigated whether it detects OPP (Overt Pronoun Penalty)
DOI: 10.17632/dbnnjpt6f8.1
title: A scientometrics investigation of phase change materials (PCM): Dataset

description: Dataset and data from WOS related on A scientometrics investigation of phase change materials (PCM)
DOI: 10.17632/s6k8s3dc67.1
title: Accuracy of artificial intelligence-diagnosed endoscopic remission in ulcerative colitis: A systematic review and meta-analysis

description: Data used for meta-analysis
DOI: 10.17632/h6rbdnh4gn.1
title: Supplementary materials for article entitled "LDL-C, Type 2 Diabetes, Autoimmune Hypothyroidism, and Uric Acid in Relation to Psoriasis and Psoriasis Arthritis: A Bidirectional Mendelian Randomization Study"

description: Supplementary materials for article entitled "LDL-C, Type 2 Diabetes, Autoimmune Hypothyroidism, and Uric Acid in Relation to Psoriasis and Psoriasis Arthritis: A Bidirectional Mendelian Randomization Study"