cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21335/nmdc-1473196070-s2_5
title: CTD profile from 78.41898333333333 N, 17.19195 E in Isfjorden, Svalbard, sampled at 05.11.2022, 09:09 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.41898333333333 N, 17.19195 E at 05.11.2022, 09:09 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-s2_6
title: CTD profile from 78.42101666666667 N, 17.183366666666668 E in Isfjorden, Svalbard, sampled at 05.11.2022, 09:18 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.42101666666667 N, 17.183366666666668 E at 05.11.2022, 09:18 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.5281/zenodo.6953652
title: Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis

description: This record contains raw data related to the article "Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis" Abstract: Prenylcysteine Oxidase 1 (PCYOX1) is an enzyme involved in the degradation of prenylated<br> proteins. It is expressed in different tissues including vascular and blood cells. We recently<br> showed that the secretome from Pcyox1-silenced cells reduced platelet adhesion both to fibrinogen<br> and endothelial cells, suggesting a potential contribution of PCYOX1 into thrombus formation. Here,<br> we show that in vivo thrombus formation after FeCl3 injury of the carotid artery was delayed in<br> Pcyox1􀀀/􀀀 mice, which were also protected from collagen/epinephrine induced thromboembolism.<br> The Pcyox1􀀀/􀀀 mice displayed normal blood cells count, vascular procoagulant activity and plasma<br> fibrinogen levels. Deletion of Pcyox1 reduced the platelet/leukocyte aggregates in whole blood, as<br> well as the platelet aggregation, the alpha granules release, and the IIb3 integrin activation in<br> platelet-rich plasma, in response to adenosine diphosphate (ADP) or thrombin receptor agonist peptide<br> (TRAP).Washed platelets from the Pcyox1􀀀/􀀀 and WT animals showed similar phosphorylation<br> pathway activation, adhesion ability and aggregation. The presence of Pcyox1􀀀/􀀀 plasma impaired<br> agonist-induced WT platelet aggregation. Our findings show that the absence of PCYOX1 results<br> in platelet hypo-reactivity and impaired arterial thrombosis, and indicates that PCYOX1 could be a<br> novel target for antithrombotic drugs.
description: This work was funded by the Italian Ministry of Health, Italy (Ricerca Corrente ID 2755301 MPP 1A, ID 2757640MPP 2B and Ricerca Finalizzata RF-2013-02355543)
DOI: 10.5281/zenodo.6953653
title: Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis

description: This record contains raw data related to the article "Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis" Abstract: Prenylcysteine Oxidase 1 (PCYOX1) is an enzyme involved in the degradation of prenylated<br> proteins. It is expressed in different tissues including vascular and blood cells. We recently<br> showed that the secretome from Pcyox1-silenced cells reduced platelet adhesion both to fibrinogen<br> and endothelial cells, suggesting a potential contribution of PCYOX1 into thrombus formation. Here,<br> we show that in vivo thrombus formation after FeCl3 injury of the carotid artery was delayed in<br> Pcyox1􀀀/􀀀 mice, which were also protected from collagen/epinephrine induced thromboembolism.<br> The Pcyox1􀀀/􀀀 mice displayed normal blood cells count, vascular procoagulant activity and plasma<br> fibrinogen levels. Deletion of Pcyox1 reduced the platelet/leukocyte aggregates in whole blood, as<br> well as the platelet aggregation, the alpha granules release, and the IIb3 integrin activation in<br> platelet-rich plasma, in response to adenosine diphosphate (ADP) or thrombin receptor agonist peptide<br> (TRAP).Washed platelets from the Pcyox1􀀀/􀀀 and WT animals showed similar phosphorylation<br> pathway activation, adhesion ability and aggregation. The presence of Pcyox1􀀀/􀀀 plasma impaired<br> agonist-induced WT platelet aggregation. Our findings show that the absence of PCYOX1 results<br> in platelet hypo-reactivity and impaired arterial thrombosis, and indicates that PCYOX1 could be a<br> novel target for antithrombotic drugs.
description: This work was funded by the Italian Ministry of Health, Italy (Ricerca Corrente ID 2755301 MPP 1A, ID 2757640MPP 2B and Ricerca Finalizzata RF-2013-02355543)
DOI: 10.21335/nmdc-1473196070-s2_7
title: CTD profile from 78.4239 N, 17.1713 E in Isfjorden, Svalbard, sampled at 05.11.2022, 09:28 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.4239 N, 17.1713 E at 05.11.2022, 09:28 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-s2_8
title: CTD profile from 78.42678333333333 N, 17.159383333333334 E in Isfjorden, Svalbard, sampled at 05.11.2022, 09:38 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.42678333333333 N, 17.159383333333334 E at 05.11.2022, 09:38 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-s2_9
title: CTD profile from 78.4288 N, 17.13981666666667 E in Isfjorden, Svalbard, sampled at 05.11.2022, 09:50 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.4288 N, 17.13981666666667 E at 05.11.2022, 09:50 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.6084/m9.figshare.21755864
title: PCA_critique.zip

description: These datasets accompany the GitHub deposit: https://github.com/eelhaik/PCA_critique <br> and include the genotype data
DOI: 10.21335/nmdc-1473196070-s2_10
title: CTD profile from 78.4312 N, 17.1384 E in Isfjorden, Svalbard, sampled at 05.11.2022, 10:01 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.4312 N, 17.1384 E at 05.11.2022, 10:01 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-s2_11
title: CTD profile from 78.43261666666666 N, 17.131733333333333 E in Isfjorden, Svalbard, sampled at 05.11.2022, 10:07 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.43261666666666 N, 17.131733333333333 E at 05.11.2022, 10:07 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-s2_12
title: CTD profile from 78.43393333333333 N, 17.126733333333334 E in Isfjorden, Svalbard, sampled at 05.11.2022, 10:14 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.43393333333333 N, 17.126733333333334 E at 05.11.2022, 10:14 UTC using a Seabird SBE19v2plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-a15
title: CTD profile from 78.23533333333333 N, 15.6695 E in Isfjorden, Svalbard, sampled at 31.10.2022, 16:51 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.23533333333333 N, 15.6695 E at 31.10.2022, 16:51 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-a13
title: CTD profile from 78.24216666666666 N, 15.632666666666667 E in Isfjorden, Svalbard, sampled at 31.10.2022, 17:37 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.24216666666666 N, 15.632666666666667 E at 31.10.2022, 17:37 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-a9
title: CTD profile from 78.24833333333333 N, 15.586 E in Isfjorden, Svalbard, sampled at 31.10.2022, 18:00 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.24833333333333 N, 15.586 E at 31.10.2022, 18:00 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-322
title: CTD profile from 78.25416666666666 N, 15.506666666666666 E in Isfjorden, Svalbard, sampled at 31.10.2022, 18:25 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.25416666666666 N, 15.506666666666666 E at 31.10.2022, 18:25 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-993
title: CTD profile from 78.2605 N, 15.5315 E in Isfjorden, Svalbard, sampled at 31.10.2022, 18:56 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.2605 N, 15.5315 E at 31.10.2022, 18:56 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.25934/pr00005345.0
title: Available datapackage for study 'A Multicenter, Double-Blind, Placebo-Controlled, Randomized Withdrawal, Parallel Group Study To Evaluate The Efficacy And Safety Of 50 mg/Day Of DVS SR In Adult Outpatients With Major Depressive Disorder'

description: The primary purpose of this study is to compare the long-term efficacy and safety of desvenlafaxine succinate sustained release versus placebo in adults with Major Depressive Disorder, using a randomized withdrawal design. Randomized withdrawal means that after receiving desvenlafaxine succinate sustained release for a predetermined period of time, subjects will be selected by chance to either continue receiving the study drug or to be withdrawn from the study drug and receive placebo for the remainder of their participation in the trial. Subjects will not know to which group they have been assigned. The study consists of an up to 14-day screening period followed by an 8-week open-label period in which subjects will knowingly receive 50 mg/day of desvenlafaxine succinate sustained release. Subjects who do not respond to treatment, demonstrating no significant change in their depressive symptoms, will be withdrawn from participation at the end of this period. Responding subjects will receive an additional 3 months of open-label desvenlafaxine succinate sustained release at the same dose. Subjects with stable response to treatment at the conclusion of this 3 month period will be randomized to either desvenlafaxine succinate sustained release at 50 mg/day or placebo in a blinded manner for an additional 6 months or until symptoms of depression return. Following discontinuation at any point after enrollment in the study, subjects will receive two weeks of follow-up monitoring, including one week of blinded taper with 25 mg/day of desvenlafaxine succinate sustained release treatment for any subjects who have been taking desvenlafaxine succinate sustained release prior to discontinuation. Subjects assigned to placebo will receive a blinded placebo taper. Following taper, subjects will be evaluated for one additional week to monitor safety.
DOI: 10.21335/nmdc-1473196070-323
title: CTD profile from 78.26583333333333 N, 15.560833333333333 E in Isfjorden, Svalbard, sampled at 31.10.2022, 19:24 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.26583333333333 N, 15.560833333333333 E at 31.10.2022, 19:24 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-324
title: CTD profile from 78.27066666666667 N, 15.5755 E in Isfjorden, Svalbard, sampled at 31.10.2022, 19:50 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.27066666666667 N, 15.5755 E at 31.10.2022, 19:50 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.5281/zenodo.6866362
title: Brain-Derived Neurotrophic Factor and extracellular vesicle-derived miRNAs in an Italian cohort of individuals with obesity: a key to explain the link between depression and atherothrombosis.

description: This record contains raw data related to the article “Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis” <em><strong>Abstract: </strong></em> <strong>Background</strong>: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs. <strong>Research Process</strong>: Associations among circulating BDNF, depression and EVderived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score.<br> <strong>Results</strong>: BDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-g. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV<br> risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group.
description: This work was partially supported by Fondazione Cariplo (2018- 0511 to MR and 2018-0525 to SB), Banca di Credito Cooperativa di Milano (donation to MR), Italian Ministry of Health, Rome, Italy (Ricerca Corrente RC 2021, and 5×1000 2018)
DOI: 10.5281/zenodo.6866363
title: Brain-Derived Neurotrophic Factor and extracellular vesicle-derived miRNAs in an Italian cohort of individuals with obesity: a key to explain the link between depression and atherothrombosis.

description: This record contains raw data related to the article “Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis” <em><strong>Abstract: </strong></em> <strong>Background</strong>: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs. <strong>Research Process</strong>: Associations among circulating BDNF, depression and EVderived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score.<br> <strong>Results</strong>: BDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-g. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV<br> risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group.
description: This work was partially supported by Fondazione Cariplo (2018- 0511 to MR and 2018-0525 to SB), Banca di Credito Cooperativa di Milano (donation to MR), Italian Ministry of Health, Rome, Italy (Ricerca Corrente RC 2021, and 5×1000 2018)
DOI: 10.21335/nmdc-1473196070-a2
title: CTD profile from 78.267 N, 15.482833333333334 E in Isfjorden, Svalbard, sampled at 31.10.2022, 20:21 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.267 N, 15.482833333333334 E at 31.10.2022, 20:21 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-165
title: CTD profile from 78.25333333333333 N, 15.311833333333333 E in Isfjorden, Svalbard, sampled at 31.10.2022, 21:02 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.25333333333333 N, 15.311833333333333 E at 31.10.2022, 21:02 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-166
title: CTD profile from 78.26566666666666 N, 15.2385 E in Isfjorden, Svalbard, sampled at 31.10.2022, 21:42 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.26566666666666 N, 15.2385 E at 31.10.2022, 21:42 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.
DOI: 10.21335/nmdc-1473196070-167
title: CTD profile from 78.27966666666667 N, 15.146666666666667 E in Isfjorden, Svalbard, sampled at 31.10.2022, 22:19 UTC during the UNIS AGF311/811-cruise.

description: The file contains temperature, practical salinity and depth measurements binned into 1 db pressure bins. The raw data was measured at 78.27966666666667 N, 15.146666666666667 E at 31.10.2022, 22:19 UTC using a Seabird SBE9plus CTD and post-processed with the Seasoft software package. The following processing steps were applied (with default settings): 1. Data Conversion, 2. Wild Edit, 3. Align CTD, 4. Cell Thermal Mass, 5. Filter, 6. Bin Average. If not specified differently, the downcast of the profile was used.