cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7924/r4c82jx2p
title: Data from: Effects of preconception exposure to rotenone on progeny depend on the degree of maternal toxicity

description: Parental exposure to toxicants can affect progeny health, including when those exposures occur prior to conception. However, most published preconception studies have involved exposures that result in loading of pollutants to gametes, or toxic effects to parents which could indirectly affect germ cell or gamete health. Here, we took advantage of the biology of Caenorhabditis elegans to carry out a preconception study in which we minimized the potential for maternal loading of toxicants, and used an exposure paradigm that either did (high concentration) or did not (low concentration) significantly impact the health of the P0 generation. We hypothesized that preconception exposure to mitochondrial toxicants during germ cell and gamete development, at levels not causing P0 toxicity, would result in altered mitochondria and organismal health in offspring. In the P0 generation, the high rotenone concentration altered growth, mitochondrial respiration, gene expression, induction of the mitochondrial unfolded protein response, and susceptibility to dopaminergic neurodegeneration induced by a chemical “rechallenge” later in life. However, we observed minor or no effects in P0 at the low concentration. In high-exposure F1 offspring, we observed altered embryo size, larval developmental stage distribution, spare respiratory capacity, heat shock protein expression, and dopaminergic neurodegeneration after a secondary rotenone challenge. The only effects observed in the F1 offspring of the low exposure were a 1.7% decrease in egg size (size later in development was normal), and moderate evidence of a slightly increased sensitivity to heat shock protein expression and dopaminergic neurodegeneration caused by a secondary later-in-life rotenone exposure.
DOI: 10.3886/e199241
title: Data and Code for: Estimating macro-fiscal effects of climate shocks

description: The literature studying the macroeconomics of weather has focused on temperature and precipitation annual averages, while micro studies have focused more on extreme weather measures. We construct hundreds of variables from high frequency, high spatial resolution weather measurements. Using the LASSO, we identify the parsimonious subset of variables that can best explain GDP and key macro-fiscal variables. We find that an increase in the occurrence of high temperatures and severe droughts, and scarcer mild temperatures reduce GDP. These variables substantially improve the share of GDP variations explained by weather. Additional evidence suggests that fiscal policy mitigates these shocks.
description: Countries of the world. Smallest Geographic Unit: country
DOI: 10.3886/e199241v1
title: Data and Code for: Estimating macro-fiscal effects of climate shocks

description: The literature studying the macroeconomics of weather has focused on temperature and precipitation annual averages, while micro studies have focused more on extreme weather measures. We construct hundreds of variables from high frequency, high spatial resolution weather measurements. Using the LASSO, we identify the parsimonious subset of variables that can best explain GDP and key macro-fiscal variables. We find that an increase in the occurrence of high temperatures and severe droughts, and scarcer mild temperatures reduce GDP. These variables substantially improve the share of GDP variations explained by weather. Additional evidence suggests that fiscal policy mitigates these shocks.
description: Countries of the world. Smallest Geographic Unit: country
DOI: 10.15468/dl.gnnftg
title: Occurrence Download

description: A dataset containing 1577 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Artibeus hirsutus K.Andersen, 1906"
 ]
}

 The dataset includes 1577 records from 51 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025506-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tqm6f9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudobarbus quathlambae (Barnard, 1938)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((30.5701 -24.0715,25.5395 -24.0715,25.5395 -28.5786,30.5701 -28.5786,30.5701 -24.0715))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025508-250525065834625/datasets/export for details.
DOI: 10.15468/dl.c3cmdu
title: Occurrence Download

description: A dataset containing 5993 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Mops Lesson, 1842",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 5993 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025505-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15610541
title: Assessing drug-induced inhibition of liver transporter function with MRI: data from the first-in-human study

description: Database

This database contains source data from a pilot study demonstrating the efficacy of MRI-based measurements of liver transporter function in detecting drug-mediated inhibition. The database is maintained by the open medical imaging biomarkers laboratory (miblab.org).

Subjects

Human healthy volunteers.

Background

The srudy is part of a series of preclinical and clinical studies performed by the TRISTAN project, in the period 2018-2024. The aim of these studies was to test if the effect of drugs on uptake and excretory function of the liver can be measured reliably with dynamic gadoxetate-enhanced MRI. Combined these studies provide proof of concept for a new MRI-based biomarker to predict the risk of liver-mediated drug-drug interactions, and of drug-induced liver injury. 

The data have been used to support a submission to the FDA's biomarker qualification program (details).

Format

All data are in dmr format - a folder with three csv files:



data.csv: Data dictionary

pars.csv: Subject parameters


The data can be read and manipulated interactively with common applications such as excel, or programmatically with the python package pydmr. 

Datasets

tristan_humans_healthy_rifampicin_data

8 healthy volunteers were assessed, before and after administration of a drug (rifampicin) which is known to inhibit liver function. The assessments were done on two separate visits at least 2 weeks apart. On each visit, the transporter function of he liver was measured with MRI and with routine standard liver function tests.

The research question was to what extent rifampicin inhibits gadoxetate uptake rate from the extracellular space into the liver hepatocytes (khe, mL/min/100mL) and excretion rate from hepatocytes to bile (kbh, mL/100mL/min). 2 of the volunteers only had the baseline assessment, the other 8 volunteers completed the full study. The results showed consistent and strong inhibition of khe (95%) and kbh (40%) by rifampicin.  Comparison to the liver function tests in this database showed that the MRI response was also more consistent. This implies that rifampicin poses a risk of drug-drug interactions (DDI), meaning it can cause another drug to circulate in the body for far longer than expected, potentially causing harm or raising a need for dose adjustment.

 





Please reference the following abstract when using these data (manuscript in preparation):

 


Thazin Min, Marta Tibiletti, Paul Hockings, Aleksandra Galetin, Ebony Gunwhy, Gerry Kenna, Nicola Melillo, Geoff JM Parker, Gunnar Schuetz, Daniel Scotcher, John Waterton, Ian Rowe, and Steven Sourbron. Measurement of liver function with dynamic gadoxetate-enhanced MRI: a validation study in healthy volunteers. Proc Intl Soc Mag Reson Med, Singapore 2024.
DOI: 10.5281/zenodo.15610540
title: Assessing drug-induced inhibition of liver transporter function with MRI: data from the first-in-human study

description: Database

This database contains source data from a pilot study demonstrating the efficacy of MRI-based measurements of liver transporter function in detecting drug-mediated inhibition. The database is maintained by the open medical imaging biomarkers laboratory (miblab.org).

Subjects

Human healthy volunteers.

Background

The srudy is part of a series of preclinical and clinical studies performed by the TRISTAN project, in the period 2018-2024. The aim of these studies was to test if the effect of drugs on uptake and excretory function of the liver can be measured reliably with dynamic gadoxetate-enhanced MRI. Combined these studies provide proof of concept for a new MRI-based biomarker to predict the risk of liver-mediated drug-drug interactions, and of drug-induced liver injury. 

The data have been used to support a submission to the FDA's biomarker qualification program (details).

Format

All data are in dmr format - a folder with three csv files:



data.csv: Data dictionary

pars.csv: Subject parameters


The data can be read and manipulated interactively with common applications such as excel, or programmatically with the python package pydmr. 

Datasets

tristan_humans_healthy_rifampicin_data

8 healthy volunteers were assessed, before and after administration of a drug (rifampicin) which is known to inhibit liver function. The assessments were done on two separate visits at least 2 weeks apart. On each visit, the transporter function of he liver was measured with MRI and with routine standard liver function tests.

The research question was to what extent rifampicin inhibits gadoxetate uptake rate from the extracellular space into the liver hepatocytes (khe, mL/min/100mL) and excretion rate from hepatocytes to bile (kbh, mL/100mL/min). 2 of the volunteers only had the baseline assessment, the other 8 volunteers completed the full study. The results showed consistent and strong inhibition of khe (95%) and kbh (40%) by rifampicin.  Comparison to the liver function tests in this database showed that the MRI response was also more consistent. This implies that rifampicin poses a risk of drug-drug interactions (DDI), meaning it can cause another drug to circulate in the body for far longer than expected, potentially causing harm or raising a need for dose adjustment.

 





Please reference the following abstract when using these data (manuscript in preparation):

 


Thazin Min, Marta Tibiletti, Paul Hockings, Aleksandra Galetin, Ebony Gunwhy, Gerry Kenna, Nicola Melillo, Geoff JM Parker, Gunnar Schuetz, Daniel Scotcher, John Waterton, Ian Rowe, and Steven Sourbron. Measurement of liver function with dynamic gadoxetate-enhanced MRI: a validation study in healthy volunteers. Proc Intl Soc Mag Reson Med, Singapore 2024.
DOI: 10.15468/dl.wv6m3j
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudobarbus quathlambae (Barnard, 1938)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((27.1332 -20.158,25.5395 -23.2724,25.5395 -24.0715,30.5701 -24.0715,30.5701 -20.3186,29.6496 -19.6123,28.947 -19.4003,28.1821 -19.4609,27.6072 -19.7214,27.1332 -20.158))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025509-250525065834625/datasets/export for details.
DOI: 10.15468/dl.v3nnf7
title: Occurrence Download

description: A dataset listing the 443393 species recorded in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 443393 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025496-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2469xb
title: Occurrence Download

description: A dataset containing 197 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Chaerephon major (Trouessart, 1897)",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 197 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025510-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.26q55y
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudobarbus quathlambae (Barnard, 1938)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((25.0214 -34.0501,25.5395 -34.1098,25.5395 -32.9007,20.509 -32.9007,20.509 -34.5676,20.524 -34.555,20.8859 -34.5419,20.9606 -34.4398,21.2995 -34.5131,21.5296 -34.4338,21.8696 -34.4439,22.0323 -34.2835,22.221 -34.2428,22.2566 -34.1304,22.5993 -34.0741,22.9652 -34.1674,23.4069 -34.1858,23.4955 -34.0792,23.6056 -34.0563,24.8471 -34.2877,24.9447 -34.2397,25.0214 -34.0501))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025512-250525065834625/datasets/export for details.
DOI: 10.15468/dl.tqhkar
title: Occurrence Download

description: A dataset containing 3757 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chione californiensis (Broderip, 1835)"
 ]
}

 The dataset includes 3757 records from 67 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025511-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60893/figshare.sss.29257562
title: 02003-05

description: Au 4f
DOI: 10.60893/figshare.sss.29257562.v1
title: 02003-05

description: Au 4f
DOI: 10.15468/dl.d8sjds
title: Occurrence Download

description: A dataset containing 73 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Chaerephon pumila (Abbot, 1894)",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 73 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025516-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60525/04teye511/yhmoiy/k0ryf2
title: 241108 - Bicentenario 2024 - Base encuesta final consolidada.rds

description: :unav
DOI: 10.60525/04teye511/yhmoiy/lgn23m
title: 241108 - Bicentenario 2024 - Base encuesta final consolidada.dta

description: :unav
DOI: 10.60525/04teye511/yhmoiy/65qyvt
title: 241118-Bicentenario_2024_Contactos_Panel.rds

description: :unav
DOI: 10.60525/04teye511/yhmoiy/gddpc3
title: Libro de Códigos Encuesta Bicentenario 2024.pdf

description: :unav
DOI: 10.60525/04teye511/yhmoiy/2mhjey
title: 241118-Bicentenario_2024_Contactos_Panel.sav

description: :unav
DOI: 10.60525/04teye511/yhmoiy/gtx9e1
title: 241108 - Bicentenario 2024 - Base encuesta final consolidada.sav

description: :unav
DOI: 10.60525/04teye511/yhmoiy/pjbit6
title: 241115 - Bicentenario 2024 - Informe terreno y ponderación.pdf

description: :unav
DOI: 10.60525/04teye511/yhmoiy/5vcj8x
title: 241115 - 91-Bicentenario 2024 - Sabana de resultados v1.xlsx

description: :unav
DOI: 10.60525/04teye511/yhmoiy/sv9vxs
title: 241116 - Bicentenario 2024 - metodología v1.pptx

description: :unav
DOI: 10.60525/04teye511/yhmoiy/vr4z2o
title: 241118-Bicentenario_2024_Contactos_Panel.dta

description: :unav
DOI: 10.60525/04teye511/yhmoiy
title: Conjunto de datos: Encuesta Nacional Bicentenario UC 2024

description: La Encuesta Nacional Bicentenario UC es un estudio de tipo cuantitativo probabilístico, se realiza mediante entrevistas personales (cara a cara) en distintos hogares de nuestro país. La población objetivo corresponde a personas de 18 años y más, chilenos o residentes en Chile, que habitan (por más de seis meses) en viviendas particulares ocupadas y localizadas en zonas urbanas a nivel nacional.
DOI: 10.15468/dl.dhqrbv
title: Occurrence Download

description: A dataset listing the 8 species recorded in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Country is Mexico",
 "OccurrenceStatus is Present",
 "TaxonKey is Manihot esculenta Crantz"
 ]
}

 The dataset's 8 records were derived from 60 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025507-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x4er6v
title: Occurrence Download

description: A dataset containing 956 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Country is Mexico",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Oryza L., Oryza grandiglumis (Döll) Prodoehl)"
 ]
}

 The dataset includes 956 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025517-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rs2g9g
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudobarbus quathlambae (Barnard, 1938)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((32.064 -28.9416,32.4847 -28.5786,30.5701 -28.5786,30.5701 -30.7329,30.6252 -30.6659,31.4179 -29.4257,31.8178 -29.0299,32.064 -28.9416))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025515-250525065834625/datasets/export for details.
DOI: 10.15468/dl.2b2m2a
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Dysopes pumilus Cretzschmar, 1826",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025518-250525065834625/datasets/export for details.
DOI: 10.15468/dl.rbvg4f
title: Occurrence Download

description: A dataset containing 112 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Panama",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Cornutia pyramidata L."
 ]
}

 The dataset includes 112 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025519-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mgd46j
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudobarbus quathlambae (Barnard, 1938)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((35.5808 -24.13,35.5909 -24.0715,30.5701 -24.0715,30.5701 -28.5786,32.4847 -28.5786,32.55 -28.5222,33.0346 -26.8668,32.9741 -26.7838,33.0415 -26.059,32.9304 -26.0011,32.7994 -26.1281,32.6834 -26.0015,32.813 -25.8728,32.8513 -25.7166,33.3048 -25.3731,35.1489 -24.6699,35.5808 -24.13))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025520-250525065834625/datasets/export for details.
DOI: 10.15468/dl.hxv8ha
title: Occurrence Download

description: A dataset containing 1858 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chione undatella (G.B.Sowerby I, 1835)"
 ]
}

 The dataset includes 1858 records from 75 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025521-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7qrq96
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pseudobarbus quathlambae (Barnard, 1938)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((31.8862 -21.3285,30.5701 -20.3186,30.5701 -24.0715,35.5909 -24.0715,35.6007 -24.0157,35.6007 -23.8125,35.4969 -23.7035,35.6007 -23.165,35.6007 -22.9702,35.227 -22.2482,34.6862 -21.6944,34.013 -21.3095,33.5 -21.1593,32.9675 -21.1092,32.4352 -21.1612,31.8862 -21.3285))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025524-250525065834625/datasets/export for details.