cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7565297
title: Supplementary Material for: Rapidly and Slowly Growing Lineages in Chromosomal Instability-Type Gland-Forming Gastric Carcinomas as Revealed by Multisampling Analysis of DNA Copy-Number Profile

description: <b><i>Background:</i></b> To examine whether gastric carcinoma (GC) with chromosomal instability (CIN-type GC), the largest category in the Cancer Genome Atlas classification, consists of a single genetic lineage, we conducted a multisampling analysis of genomic DNA copy-number profile. <b><i>Methods:</i></b> We performed array-based comparative genomic hybridization using formalin-fixed paraffin-embedded tissues from 54 gland-forming GCs containing a total of 106 DNA samples from mucosal, extramucosal invasive, and lymph node lesions. Microarray data were analyzed by unsupervised hierarchical clustering and penetrance plots. Epstein-Barr virus infection status and mismatch repair (MMR) enzyme-silencing/p53/mucin expression were examined by in situ hybridization and immunohistochemistry, respectively. <b><i>Results:</i></b> The samples examined were divided into gain-rich cluster A and loss-rich cluster B, which were different in tumor locus and patient age. The T1/T2–4 ratio, the frequency of small cancers (diameter ≤2–4 cm), and intestinal mucin expression were higher in cluster B than in cluster A, but there were no significant differences in the frequencies of MMR silencing, mutant p53 pattern, and lymph node metastasis between the 2 clusters. <b><i>Conclusions:</i></b> We demonstrated that CIN-type GC could be categorized into 2 genetic lineages which are different in terms of rapidity of local extension but similar in terms of nodal metastasis risk.
DOI: 10.7910/dvn/p0fcki/lgbu6q
title: 1-43.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/unvpru
title: 1-30.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/110922
title: Singlebeam Echosounder data collected during research cruise HLY0901 using a Knudsen 320B/R instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/wpuxaz
title: 1-11.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/121356
title: TSG (Thermosalinograph) data collected during research cruise HLY0901 using a Sea-Bird SBE-45 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/vzcbh4
title: 1-27.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.7565171
title: Supplementary Material for: The miR-183/96/182 Cluster Regulates Macrophage Functions in Response to <b><i>Pseudomonas aeruginosa</i></b>

description: Macrophages (Mϕ) are an important component of the innate immune system; they play critical roles in the first line of defense to pathogen invasion and modulate adaptive immunity. MicroRNAs (miRNAs) are a newly recognized, important level of gene expression regulation. However, their roles in the regulation of Mϕ and the immune system are still not fully understood. In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mϕ function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to <i>Pseudomonas aeruginosa</i> (PA) infection and/or lipopolysaccharide (LPS) treatment. We show that knockdown of miR-183/96/182 results in decreased production of multiple proinflammatory cytokines in response to PA or LPS treatment in Mϕ-like Raw264.7 cells. Consistently, peritoneal Mϕ from miR-183/96/182-knockout versus wild-type mice are less responsive to PA or LPS<b><i>,</i></b> although their basal levels of proinflammatory cytokines are increased. In addition, overexpression of miR-183/96/182 results in decreased production of nitrite and ROS in Raw264.7 cells. We also provide evidence that DAP12 and Nox2 are downstream target genes of miR-183/96/182. These data suggest that miR-183/96/182 imposes global regulation on various aspects of Mϕ function through different downstream target genes.
DOI: 10.7284/110519
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise HLY0902 using a Sea-Bird SBE-911+ instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/qhhcu8
title: 1-48.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/4mgx2f
title: 1-25.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/101891
title: INS (Inertial Navigation System) data collected during research cruise HLY0902 using a Applanix POS/MV-320 V2 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/vogk4y
title: 1-33.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/x4kkp2
title: 1-34.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/100211
title: Multibeam Echosounder data collected during research cruise HLY0902 using a SeaBeam 2112 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/c6xizq
title: 1-19.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.7565030
title: Supplementary Material for: Mastocytosis and the Fig Wasp (<b><i>Blastophaga psenes</i></b>)

description: <b><i>Background:</i></b> Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen, often associated with Hymenoptera allergens, must be identified. The common fig (<i>Ficus carica</i>) requires the fig wasp (<i>Blastophaga psenes</i>) for pollination. <b><i>Objective:</i></b> We evaluated the ingestion of <i>B.</i> <i>psenes</i> as a trigger of anaphylaxis in patients with mastocytosis. <b><i>Material and Methods:</i></b> Skin prick tests (SPTs) and specific immunoglobulin E to the possible involved allergens were carried out in the patient and in 4 controls allergic to Hymenoptera and fig. Given the possibility of hidden allergens, we studied the source (figs of various origins) and possible hypersensitivity to Hymenoptera allergens, including the fig wasp (<i>B. psenes</i>). <b><i>Results:</i></b> In all subjects, the SPT resulted in a wheal (larger than with histamine) with the extract of the inferior part of the female fig but not with the male extract (lower pole and stem). Immune detection was made with the stem and inferior part of figs and venom of <i>Polistes</i> and <i>Vespula</i>. Recognition bands were observed at 25 kDa with female fig extracts that were also recognized by the patient with anaphylaxis to Hymenoptera venom. <b><i>Conclusions:</i></b> We cannot exclude the possibility that the ingestion of fig with <i>Blastophaga</i> antigens may have triggered anaphylaxis in our patient.
DOI: 10.7910/dvn/p0fcki/z9mqul
title: 1.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.7565030.v1
title: Supplementary Material for: Mastocytosis and the Fig Wasp (<b><i>Blastophaga psenes</i></b>)

description: <b><i>Background:</i></b> Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen, often associated with Hymenoptera allergens, must be identified. The common fig (<i>Ficus carica</i>) requires the fig wasp (<i>Blastophaga psenes</i>) for pollination. <b><i>Objective:</i></b> We evaluated the ingestion of <i>B.</i> <i>psenes</i> as a trigger of anaphylaxis in patients with mastocytosis. <b><i>Material and Methods:</i></b> Skin prick tests (SPTs) and specific immunoglobulin E to the possible involved allergens were carried out in the patient and in 4 controls allergic to Hymenoptera and fig. Given the possibility of hidden allergens, we studied the source (figs of various origins) and possible hypersensitivity to Hymenoptera allergens, including the fig wasp (<i>B. psenes</i>). <b><i>Results:</i></b> In all subjects, the SPT resulted in a wheal (larger than with histamine) with the extract of the inferior part of the female fig but not with the male extract (lower pole and stem). Immune detection was made with the stem and inferior part of figs and venom of <i>Polistes</i> and <i>Vespula</i>. Recognition bands were observed at 25 kDa with female fig extracts that were also recognized by the patient with anaphylaxis to Hymenoptera venom. <b><i>Conclusions:</i></b> We cannot exclude the possibility that the ingestion of fig with <i>Blastophaga</i> antigens may have triggered anaphylaxis in our patient.
DOI: 10.7284/110923
title: Singlebeam Echosounder data collected during research cruise HLY0902 using a Knudsen 320B/R instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7565027
title: Fungi associated with <i>Cryphalus rhusi</i> (Scolytinae; Coleoptera) infesting lacquer tree, <i>Toxicodendron vernicifluum</i>

description: We have examined the fungi associated with the scolytid bark beetle, <i>Cryphalus rhusi</i>, which infests the lacquer tree <i>Toxicodendron vernicifluum</i>. The fungi were also evaluated for pathogenicity in <i>T. vernicifluum</i> as a step toward clarifying the potential of the beetle for tree damage. Three fungal species, a <i>Yamadazyma</i> sp., a <i>Fusarium</i> sp., and <i>Penicillium pinophilum</i> were isolated from adult beetles that had emerged from branches. Of these, the <i>Yamadazyma</i> sp. appeared to be a close associate of the beetle, since it was isolated from all individuals used in the study, while the others were much less frequent. Pathogenicity tests revealed that the <i>Fusarium</i> sp. caused slightly larger lesions (by 2 mm) than the negative controls, whereas the <i>Yamadazyma</i> sp. did not cause any symptoms. We conclude that <i>C. rhusi</i>, with its associated fungi, is not likely to be a serious pest for <i>T. vernicifluum</i>.
DOI: 10.7910/dvn/p0fcki/bbhiki
title: 1-28.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.7565027.v1
title: Fungi associated with <i>Cryphalus rhusi</i> (Scolytinae; Coleoptera) infesting lacquer tree, <i>Toxicodendron vernicifluum</i>

description: We have examined the fungi associated with the scolytid bark beetle, <i>Cryphalus rhusi</i>, which infests the lacquer tree <i>Toxicodendron vernicifluum</i>. The fungi were also evaluated for pathogenicity in <i>T. vernicifluum</i> as a step toward clarifying the potential of the beetle for tree damage. Three fungal species, a <i>Yamadazyma</i> sp., a <i>Fusarium</i> sp., and <i>Penicillium pinophilum</i> were isolated from adult beetles that had emerged from branches. Of these, the <i>Yamadazyma</i> sp. appeared to be a close associate of the beetle, since it was isolated from all individuals used in the study, while the others were much less frequent. Pathogenicity tests revealed that the <i>Fusarium</i> sp. caused slightly larger lesions (by 2 mm) than the negative controls, whereas the <i>Yamadazyma</i> sp. did not cause any symptoms. We conclude that <i>C. rhusi</i>, with its associated fungi, is not likely to be a serious pest for <i>T. vernicifluum</i>.
DOI: 10.7284/121357
title: TSG (Thermosalinograph) data collected during research cruise HLY0902 using a Sea-Bird SBE-45 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/bxlzng
title: 1-22.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/101892
title: INS (Inertial Navigation System) data collected during research cruise HLY0904 using a Applanix POS/MV-320 V2 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/hysfip
title: 1-42.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/mrsfgk
title: 1-37.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/100214
title: Multibeam Echosounder data collected during research cruise HLY0904 using a SeaBeam 2112 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/r9ylbe
title: 1-9.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/110926
title: Singlebeam Echosounder data collected during research cruise HLY0904 using a Knudsen 320B/R instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/c0mlgp
title: 1-5.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/wqepxr
title: 1-16.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/101893
title: INS (Inertial Navigation System) data collected during research cruise HLY0905 using a Applanix POS/MV-320 V2 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/4ctee4
title: 1-32.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/hxisru
title: 1-1.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/100215
title: Multibeam Echosounder data collected during research cruise HLY0905 using a SeaBeam 2112 instrument system onboard the platform USCGC Healy
DOI: 10.7910/dvn/p0fcki/wcg8ke
title: 1-51.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/110517
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise HLY09TA using a Sea-Bird SBE-911+ instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/4rss5j
title: 1-3.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/hnykxn
title: 1-36.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.6084/m9.figshare.7564922
title: Supplementary Material for: Intravenous Misuse of Methadone, Buprenorphine and Buprenorphine-Naloxone in Patients Under Opioid Maintenance Treatment: A Cross-Sectional Multicentre Study

description: <b><i>Background:</i></b> The act of intravenous misuse is common in patients under opioid maintenance treatment (OMT), but information on associated factors is still limited. <b><i>Objectives:</i></b> To explore factors associated with (a) intravenous OMT misuse, (b) repeated misuse, (c) emergency room (ER) admission, (d) misuse of different OMT types and (e) concurrent benzodiazepine misuse. <b><i>Methods:</i></b> We recruited 3,620 patients in 27 addiction units in Italy and collected data on the self-reported rate of intravenous injection of methadone (MET), buprenorphine (BUP), BUP-naloxone (NLX), OMT dosage and type, experience of and reason for misuse, concurrent intravenous benzodiazepine misuse, pattern of ­misuse in relation to admission to the addiction unit and ER ­admissions because of misuse. According to inclusion/exclusion criteria, 2,585 patients were included. <b><i>Results:</i></b> Intravenous misuse of OMT substances was found in 28% of patients with no difference between OMT types and was associated with gender, age, type of previous opioid abuse and intravenous benzodiazepine misuse. Repeated OMT misuse was reported by 20% (i.e., 71% of misusers) of patients and was associated with positive OMT misuse experience and intravenous benzodiazepine misuse. Admission to the ER because of misuse complications was reported by 34% of patients, this outcome being associated with gender, employment, type of previous opioid abuse and intravenous benzodiazepine misuse. OMT dosage was lower than the recommended maintenance dosage. <b><i>Conclusions:</i></b> We offered new information on factors associated with intravenous OMT misuse, repeated misuse and ER admission in Italian patients under OMT. Our data indicate that BUP-NLX misuse is not different from that of BUP or MET. Choosing the more expensive BUP-NLX over MET will likely not lead to the expected reduction of the risk of injection misuse of the OMT. Instead of prescribing new and expensive OMT formulations, addiction unit physicians and medical personnel should better focus on patient’s features that are associated with a higher likelihood of misuse. Care should be paid to concurrent benzodiazepine and OMT misuse.
DOI: 10.7284/101894
title: INS (Inertial Navigation System) data collected during research cruise HLY09TA using a Applanix POS/MV-320 V2 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7910/dvn/p0fcki/waomob
title: 1-39.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7910/dvn/p0fcki/v8guro
title: 1-14.25V

description: sigma=1.25Volts; This is a FITS file with 1 (primary) HDU. The following recognized metadata keys have been found in the FITS file: NAXIS2; NAXIS; NAXIS1; NAXIS0;
DOI: 10.7284/100208
title: Multibeam Echosounder data collected during research cruise HLY09TA using a SeaBeam 2112 instrument system onboard the platform USCGC Healy

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7564901
title: Supplementary Material for: Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

description: <b><i>Background:</i></b> The risk factors associated with the development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD) are still unclear. The aim of the present study was to identify such risk factors in NAFLD patients who developed HCC. <b><i>Methods:</i></b> Between April 2000 and ­December 2016, a total of 182 patients with NAFLD were enrolled in this study; of these, only 22 patients had HCC. To identify risk factors, univariate and multivariate analyses were performed. To identify risk factors other than the degree of fibrosis, propensity matched analysis adjusted by the NAFLD fibrosis score (NFS) was carried out on 44 patients. Multivariate and survival analyses were also performed in HCC patients. <b><i>Results</i></b>: In 182 patients, multivariate analysis highlighted the NFS (OR 2.275; <i>p</i> &lt; 0.001) and hypertension (OR 5.868; <i>p</i> = 0.037) as independent factors that were significantly associated with the development of HCC. After adjustment for the NFS, multivariate analysis identified diabetic retinopathy (OR 8.654; <i>p</i> = 0.017) as an independent factor that was significantly associated with the development of HCC. For predicting the development of HCC, the area under the receiver operating characteristic curve of diabetic retinopathy was significantly higher than that of diabetes (0.731 vs. 0.615; <i>p</i> &lt; 0.001). In patients with HCC, multivariate analysis indicated that the NFS were significantly associated with diabetic retinopathy. <b><i>Conclusions:</i></b> Diabetic retinopathy as well as liver fibrosis is a risk factor that associates with the development of HCC in NAFLD patients. Therefore, NAFLD patients with diabetic retinopathy should undergo careful screening for HCC.