cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13414893
title: Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis

description: Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. We consecutively recruited eligible subjects with moderate-severe CAS (<i>n</i> = 60), aortic sclerosis (ASc) (<i>n</i> = 49) and age and gender-matched control subjects (<i>n</i> = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all <i>p</i> &gt; 0.05). CAS patients had higher plasma choline levels compared to both control (<i>p</i> p = 0.006). Plasma betaine and TMAO levels were similar (both <i>p</i> &gt; 0.05). Compared to the lowest quartile choline levels (&lt;11.15 μM), patients with the highest quartile choline levels (≥14.98 μM) had higher aortic valvular (<i>p</i> p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B ± SE:0.165 ± 0.060, <i>p</i> = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (<i>p</i> p = 0.011), osseous metaplasia (<i>p</i> = 0.004), more severe tissue remodelling (<i>p</i> = 0.002) and calcification (<i>p</i> = 0.002). We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
DOI: 10.6084/m9.figshare.13414893.v3
title: Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis

description: Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. We consecutively recruited eligible subjects with moderate-severe CAS (<i>n</i> = 60), aortic sclerosis (ASc) (<i>n</i> = 49) and age and gender-matched control subjects (<i>n</i> = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all <i>p</i> &gt; 0.05). CAS patients had higher plasma choline levels compared to both control (<i>p</i> p = 0.006). Plasma betaine and TMAO levels were similar (both <i>p</i> &gt; 0.05). Compared to the lowest quartile choline levels (&lt;11.15 μM), patients with the highest quartile choline levels (≥14.98 μM) had higher aortic valvular (<i>p</i> p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B ± SE:0.165 ± 0.060, <i>p</i> = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (<i>p</i> p = 0.011), osseous metaplasia (<i>p</i> = 0.004), more severe tissue remodelling (<i>p</i> = 0.002) and calcification (<i>p</i> = 0.002). We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
DOI: 10.6084/m9.figshare.13414893.v2
title: Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis

description: Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. We consecutively recruited eligible subjects with moderate-severe CAS (<i>n</i> = 60), aortic sclerosis (ASc) (<i>n</i> = 49) and age and gender-matched control subjects (<i>n</i> = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all <i>p</i> &gt; 0.05). CAS patients had higher plasma choline levels compared to both control (<i>p</i> p = 0.006). Plasma betaine and TMAO levels were similar (both <i>p</i> &gt; 0.05). Compared to the lowest quartile choline levels (&lt;11.15 μM), patients with the highest quartile choline levels (≥14.98 μM) had higher aortic valvular (<i>p</i> p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B ± SE:0.165 ± 0.060, <i>p</i> = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (<i>p</i> p = 0.011), osseous metaplasia (<i>p</i> = 0.004), more severe tissue remodelling (<i>p</i> = 0.002) and calcification (<i>p</i> = 0.002). We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
DOI: 10.5281/zenodo.5094327
title: Opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials. Nominal group

description: Nominal group database to find out the opinion of ethics committee representatives on the use of social networks and new technologies in clinical trials.
DOI: 10.26050/wdcc/rra_wrf_simulations
title: WRF dynamical downscaling of present-day and mid-Pliocene atmospheric conditions over High Mountain Asia

description: Project: Regionally Refined Analyses - Dynamical downscaling of global gridded data sets from operational analyses, reanalyses, paleoclimate simulations and climate projections for various regions and time periods by a numerical weather prediction model applying daily reinitialization and cascaded nesting approaches. Find our website at https://www.klima.tu-berlin.de/ Summary: The data was produced employing the Advanced Research Weather Research and Forecasting model (WRF) version 4.1.2 (Skamarock et al., 2019) for the dynamical downscaling of GCM data. WRF is a fully compressible non-hydrostatic atmospheric simulation system. Two sensitivity simulations were conducted using 15-year time slices for the present day and the mid-Pliocene simulated by ECHAM5 as initial and boundary conditions (Mutz et al., 2018; Botsyun et al., 2020). Except for the atmospheric forcing data, other parameters were the same in both simulations. The model domain has a grid spacing of 30 km. In the vertical direction, 28 terrain-following eta-levels were used. The model time steps are 120 seconds with a 6 hourly data output and are aggregated to daily values in post processing. The boundary conditions were updated every 6 h. The daily re-initialization strategy from Maussion et al. (2011) and Maussion et al. (2014) were employed: each simulation starts at 12 UTC and contains 36 h, with the first 12 h as the spin-up time. This strategy kept the large-scale circulation patterns simulated by WRF closely constrained by the forcing data, while concurrently allowing WRF to develop the mesoscale atmospheric features. Physical parameterization schemes were consistent with the ones used for high-resolution dynamical downscaling in High Mountain Asia in Wang et al. (2021). The data format follows the guidelines of the [UC]² Data Standard (http://www.uc2-program.org/uc2_data_standard.pdf).
DOI: 10.1285/i25327518v5i1p1
title: Title page
DOI: 10.1285/i25327518v5i1p3
title: Index
DOI: 10.1285/i25327518v5i1p5
title: Introduction
DOI: 10.1285/i25327518v5i1p7
title: The bidirectional interaction between our gut flora and drugs

description: The term "pharmacogenetics" refers to the study of individual genetic variations that give rise to different responses to the intake of a drug. Recently, however, it has begun to think that an important role in this sense can also be played by our microbiota. The interaction between our gut microbial flora and drugs is actually bidirectional: evidence has accumulated that some drugs, in addition to classical antibiotics, have a strong impact on the composition of the microbiota.
DOI: 10.1285/i25327518v5i1p11
title: The Eye-tracking technology in the healthcare settings: an observational, cross sectional, multicenter study

description: Successful communication is considered an essential component of the quality of care and safety of the patient with Amyotrophic Lateral Sclerosis (ALS). Recent technology has provided alternative communication systems, including the Eye-tracking technology, which enables interaction with others in the more advanced stages of the disease. The aim of the study is to investigate patients' difficulties in using the eye tracker, their problem in obtaining the device and the clinical complications resulting from it. A "snowball sampling" method study was conducted from April to September 2020 until sample saturation. The results of the study demonstrate the countless difficulties in obtaining the eye- tracker, with long waiting times, which are not followed by adequate training in its correct use. Among the consequences linked to the use of this device, the most frequent were nystagmus (8.8%), onset of eyelid ptosis (16.2%) and the appearance of increased fatigue. 56.1% of the sample used the eye tracker to surf the Internet whereas 9.1% used it to write e-mails. Overall, the use of the eye tracker led to an improvement in overall quality of life (24%). In Conclusions, the Eye-tracking technology is a valuable device for Alternative Augmentative Communication (AAC) in ALS patients and can be used with good performance, therefore the need for information, training and improvement on this topic is essential
DOI: 10.1285/i25327518v5i1p19
title: Polygraphic findings in simplified Barbed Reposition Pharyngoplasty (BRP) as a treatment for OSA patients

description: This study aims to compare polygraphic data in patients with OSA treated with Barbed Reposition Pharyngoplasty (BRP) performed with a simplified technique compared to the standard method. Variations of technique were performed and tested with the purpose of promoting tolerability and diffusion of this simplified technique. To evaluate the efficacy of the simplified BRP method, a sample of 99 patients was divided into two groups: Group A was treated with BRP (BRP group) and Group B was treated with simplified BRP (sBRP group). The results obtained on the two groups were compared with the two sample Bootstrap t-tests method, showing a substantial overlap in polygraphic results recorded 6 months after surgery.
DOI: 10.1285/i25327518v5i1p27
title: Adenoid Cystic Carcinoma of the Bartholin Gland. A Morphological and Immunohistochemical study of a rare case

description: Adenoid cystic carcinoma of the Bartholin gland (BG-ACC) is a rare form of vulvar cancer. Literature reported approximately 350 cases of BG-ACC since 1864. Literature data and case reports suggested an aggressive nature with protracted clinical symptoms and a tendency for local recurrence despite adequate surgical excision with or without adjuvant radiotherapy. Survival rates of 71% and 59% are reported, respectively, at five and ten years. A comparative analysis of the immunohistochemical profile was performed with the homologous tumor of the salivary glands, and it was observed that the expression of various antigen in different morphological patterns of this neoplasia allowed some considerations about on its histogenesis that was hitherto never proposed.
DOI: 10.1285/i25327518v5i1p33
title: How is suspected transthyretin-related cardiac amyloidosis diagnosed? Role 99mTc-HDMP scintigraphy: a substitute for biopsy?

description: Cardiac amyloidosis (CA) is characterized by extracellular deposition of protein-derived fibrils and lead to heart failure. Gold standard for its etiological diagnosis is endomyocardial biopsy and laboratory tests, both high-cost and invasive procedures. Technetium- 99m hydroxymethylene diphosphonate (99mTc-HMDP) scintigraphy is important tool for defining CA, specifically transthyretin subtype (ATTR). From July 2020 to February 2021, we retrospectively analyzed 18 pts [14 males, 4 females; aged 32-86y] with suspected ATTR, underwent to scintigraphy 150 min after iv administration of 740 MBq 99mTc-HMDP.Myocardial uptake was assessed optically based on Perugini Score (0- 3). Biopsy confirmed diagnosis. Intense (Score 3) and moderate (Score 2) myocardial uptake verified in 8 patients by 99mTc-HDMP scintigraphy, was consistent with ATTR suspect. In 10 patient's cardiac radiotracer uptake was absent (Score 0) avoiding biopsy. Our data indicate a 99mTc-HDMP scintigraphy key role in the early diagnosis but even more in the exclusion of patients with ATTR subtype, optimizing the management of pts who do not require high costs and invasive procedures.
DOI: 10.1285/i25327518v5i1p37
title: The rhythms of language: an overview of linguistic processes and neural oscillations

description: For the last decades neuroscientists have grown interest in the analysis of the rhythmic activity of the brain synchronized at temporal and spatial level. These neural oscillations, grouped by their frequency, have been proposed to govern all cognitive processes. In the field of the neurobiology of language, considerable research has linked speech processing and language comprehension to neural oscillations. On one hand, neural rhythmic activity is thought to synchronize to relevant spectral information of speech on three-time scales – which physically reflect phoneme, syllable and phrase processing. On the other hand, syntactic and semantic processing is subserved by faster oscillatory patterns not necessarily related to the acoustic properties of speech. For each linguistic process, this article summarizes the neural oscillations involved. Further evidence comes from studies on language-related pathologies.
DOI: 10.1285/i25327518v5i1p49
title: Attitudes, perceptions, and knowledge of the population on End-of-Life and Advance Treatment Declaration: an observational study in Southern Italy

description: In an advanced scientific and technological context, where it is now tangible the possibility of interfering indefinitely in the process of dying, it becomes necessary to disseminate knowledge about end of life that, for the great variety of areas that it invests, presents many controversial aspects. With the Law no. 219/2017, the right of self-determination and freedom of treatment of the patient is enshrined, aspects that to date still remain too little discussed. An online survey was conducted from December 2019 to February 2020, among the population residing in the provinces of Lecce and Brindisi, spread thanks to the collaboration of local authorities. A large part of the sample (82.4%, N=333) claims the right to self-determination, stating that therapeutic decisions are up to the patient who has signed his advance treatment dispositions, declared absolutely binding for 50% (N=205) of the sample. However, there is still a lack of information about how to draw up advance treatment agreements (AADs). 12.6% (N=51) of those interviewed stated that they knew nothing about it and only 32.9% (N=133) felt ready and adequately informed to make their own declarations. Another peculiar aspect is that topics such as euthanasia and assisted suicide seem to be considered at the margins of acceptability among End-of-Life instances. The results of the study show that knowledge on the subject has definitely improved over the years and that in most of the issues addressed, the population has an adequate degree of preparedness even though there is still some skepticism in dealing with issues such as assisted suicide and euthanasia. Future research could explore the possibility of identifying effective training tools and communication strategies that can be used by the widest possible segment of the population.
DOI: 10.1285/i25327518v5i1p60
title: Colophon
DOI: 10.1285/i25327518v5i1
title: JDReAM. Journal of InterDisciplinary Research Applied to Medicine - Vol. 5, issue 1
DOI: 10.16904/1000001.8
title: 2019 Vegetation Height Model NFI (current)
title: Vegetation Height Model NFI

description: Data 'Vegetation Height Model NFI 2019' available on request (christian.ginzler@wsl.ch). A national vegetation height model was calculated for Switzerland using digital aerial images. We used the stereo aerial images acquired by the Federal Office of Topography swisstopo using the ADS80 sensor to first calculate a digital surface model (DSM) with a very high spatial resolution (1 × 1 m). The DSM was then normalized to obtain the actual vegetation heights using the digital terrain model (DTM) SwissAlti3D based on airborne laser data. Buildings are masked out using the NDVI information of the aerial images to produce a vegetation height model, and to produce a vegetation height model (VHM). Such a model will be calculated in the framework of the Swiss National Forest Inventory (NFI) with consistent methods and a very high level of detail. For covering the whole of Switzerland, we used summer aerial images from 2013 to 2019.
description: A national vegetation height model was calculated for Switzerland using digital aerial images.We used the stereo aerial images acquired by the Federal Office of Topography swisstopo using the ADS80 sensor to first calculate a digital surface model (DSM) with a very high spatial resolution(1 × 1 m and 0.5 x 0.5 m). The DSM was then normalized to obtain the actualvegetation heights using a digital terrain model (DTM)based on laser data with the buildings masked out, and toproduce a vegetation height model (VHM). Such a modelwill be calculated in the framework of the Swiss National Forest Inventory (NFI) with consistent methods and a veryhigh level of detail. For covering the whole of Switzerland,we use summer aerial images from six years.Latest version is from 2019.
DOI: 10.15129/cc0cb14f-9329-4e42-bb99-36ca1fbbddd9
title: Data for: "Are rate and selectivity correlated in iridium-catalysed hydrogen isotope exchange reactions?"

description: This dataset comprises raw nuclear magnetic resonance (NMR) spectroscopy data for datapoints used in the manuscript. This data was collected using Bruker Topspin (v3 or v4) and is provided in Bruker Topspin format. This data can be opened with Bruker Topspin, or the fid file can be opened with any NMR data processing software, or any software that can read FID (free induction decay) files.
DOI: 10.3886/e130367v1-91560
title: Data and code for: Pay Me Later: Savings Constraints and the Demand for Deferred Payments

description: We study a simple savings scheme that allows workers to defer receipt of part of their wages for three months at zero interest. The scheme significantly increases savings during the deferral period, leading to higher post-disbursement spending on lumpy goods. Two years later, after two additional rounds of the savings scheme, we ﬁnd that treated workers have made permanent improvements to their homes. The popularity of the scheme implies a lack of good alternative savings options. The results of a follow-up experiment suggest that demand for the scheme is partly due to its ability to address self-control issues.<br><br>
description: Response Rates: Initial sample N = 870Follow-up survey 1 (FS1) N = 841 (96.7% response rate)Follow-up survey 2 (FS2) N = 810 (93.1% response rate)Follow-up survey 3 (FS3) N = 788 (90.6% response rate)Follow-up survey 4 (FS4) N = 723 (83.1% response rate)Follow-up survey 5 (FS5) N = 662 (76.1% response rate)<br><br><br>
description: Our starting sample was all permanent full-time employees of the Lujeri tea estate (1,897 workers). We collected baseline data and social network data on the 1,240 workers who expressed initial interest in the scheme, then they made an incentivized participation decision at the end of the social network survey. Our final sample is the 870 workers who were still interested in the scheme at the end of the social network survey.<br>
description: Full-time permanent employees at the Lujeri Tea Estates during the 2016-2017 main harvest season.<br>.
description: computer-assisted personal interview (CAPI); face-to-face interview;
DOI: 10.6084/m9.figshare.14973874
title: Supplementary Table 1 from RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages

description: We report here that RUFY4, a newly characterized member of the ‘RUN and FYVE domain-containing’ family of proteins previously associated with autophagy enhancement, is highly expressed in alveolar macrophages (AM). We show that RUFY4 interacts with mitochondria upon stimulation by microbial-associated molecular patterns of AM and dendritic cells. RUFY4 interaction with mitochondria and other organelles is dependent on a previously uncharacterized OmpH domain located immediately upstream of its C-terminal FYVE domain. Further, we demonstrate that <i>rufy4</i> messenger RNA can be translated from an alternative translation initiation codon, giving rise to a N-terminally truncated form of the molecule lacking most of its RUN domain and with enhanced potential for its interaction with mitochondria. Our observations point towards a role of RUFY4 in selective mitochondria clearance in activated phagocytes.
DOI: 10.6084/m9.figshare.14973874.v1
title: Supplementary Table 1 from RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages

description: We report here that RUFY4, a newly characterized member of the ‘RUN and FYVE domain-containing’ family of proteins previously associated with autophagy enhancement, is highly expressed in alveolar macrophages (AM). We show that RUFY4 interacts with mitochondria upon stimulation by microbial-associated molecular patterns of AM and dendritic cells. RUFY4 interaction with mitochondria and other organelles is dependent on a previously uncharacterized OmpH domain located immediately upstream of its C-terminal FYVE domain. Further, we demonstrate that <i>rufy4</i> messenger RNA can be translated from an alternative translation initiation codon, giving rise to a N-terminally truncated form of the molecule lacking most of its RUN domain and with enhanced potential for its interaction with mitochondria. Our observations point towards a role of RUFY4 in selective mitochondria clearance in activated phagocytes.
DOI: 10.6084/m9.figshare.14973663.v1
title: repository_data_HAS experiment.pdf

description: Supernatant fluids from human explant co-cultures consisting on synovial tissue, bone and cartilage were treated with hyperacute serum and/or hyaluronic acid after inflammatory conditions were induced. This data reprensents cytokine and growth factors measurements from those supernatant fluids, for the different conditions and at different time points.