cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7713770
title: De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

description: Switching from a potent P2Y<sub>12</sub> blocker to clopidogrel is not uncommon for antiplatelet therapy in patients undergoing percutaneous coronary intervention. This meta-analysis aimed to investigate the efficacy and safety of this de-escalation strategy. Medical literature databases were searched for analysis comparing continued potent antiplatelet therapy and switching to clopidogrel with no language restrictions from inception to 07/May/2018. The primary endpoints of major adverse cardiovascular events (MACE) and major bleeding together with additional efficacy outcomes were assessed by random-effects and fixed-effects meta-analysis. A total of 17 896 patients in 13 studies were eligible for analysis, while 17 579 (98.2%) patients presented as acute coronary syndrome and 4105 (23%) patients received the de-escalation therapy. Incidence of MACE was virtually identical in both de-escalation and standard potent antiplatelet therapy groups (odds ratio 0.91, 95% CI 0.73–1.14; <i>P</i> = 0.43). Insignificant difference was also observed in major bleeding (0.99, 0.62–1.60; <i>P</i> = 0.97), all-cause death (0.95, 0.61–1.46; <i>P</i> = 0.81), cardiovascular death (0.66, 0.31–1.42; <i>P</i> = 0.29), myocardial infarction (1.12, 0.80–1.58; <i>P</i> = 0.51), stent thrombosis (1.09, 0.50–2.36; <i>P</i> = 0.83), unplanned revascularization (1.09, 0.83–1.41; <i>P</i> = 0.54), and stroke (1.16, 0.62–2.19; <i>P</i> = 0.64). In conclusion, de-escalation of antiplatelet therapy is associated with nonsignificant differences in both ischemic events and major bleeding compared with standard potent antiplatelet therapy in patients undergoing percutaneous coronary intervention. The feasibility and even superiority of this strategy need to be elucidated by further randomized trials.
DOI: 10.6084/m9.figshare.7713770.v1
title: De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

description: Switching from a potent P2Y<sub>12</sub> blocker to clopidogrel is not uncommon for antiplatelet therapy in patients undergoing percutaneous coronary intervention. This meta-analysis aimed to investigate the efficacy and safety of this de-escalation strategy. Medical literature databases were searched for analysis comparing continued potent antiplatelet therapy and switching to clopidogrel with no language restrictions from inception to 07/May/2018. The primary endpoints of major adverse cardiovascular events (MACE) and major bleeding together with additional efficacy outcomes were assessed by random-effects and fixed-effects meta-analysis. A total of 17 896 patients in 13 studies were eligible for analysis, while 17 579 (98.2%) patients presented as acute coronary syndrome and 4105 (23%) patients received the de-escalation therapy. Incidence of MACE was virtually identical in both de-escalation and standard potent antiplatelet therapy groups (odds ratio 0.91, 95% CI 0.73–1.14; <i>P</i> = 0.43). Insignificant difference was also observed in major bleeding (0.99, 0.62–1.60; <i>P</i> = 0.97), all-cause death (0.95, 0.61–1.46; <i>P</i> = 0.81), cardiovascular death (0.66, 0.31–1.42; <i>P</i> = 0.29), myocardial infarction (1.12, 0.80–1.58; <i>P</i> = 0.51), stent thrombosis (1.09, 0.50–2.36; <i>P</i> = 0.83), unplanned revascularization (1.09, 0.83–1.41; <i>P</i> = 0.54), and stroke (1.16, 0.62–2.19; <i>P</i> = 0.64). In conclusion, de-escalation of antiplatelet therapy is associated with nonsignificant differences in both ischemic events and major bleeding compared with standard potent antiplatelet therapy in patients undergoing percutaneous coronary intervention. The feasibility and even superiority of this strategy need to be elucidated by further randomized trials.
DOI: 10.6084/m9.figshare.17150973
title: Supplemental Tables 4-10 from Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques

description: Variation in social status predicts molecular, physiological and life-history outcomes across a broad range of species, including our own. Experimental studies indicate that some of these relationships persist even when the physical environment is held constant. Here, we draw on datasets from one such study—experimental manipulation of dominance rank in captive female rhesus macaques—to investigate how social status shapes the lived experience of these animals to alter gene regulation, glucocorticoid physiology and mitochondrial DNA phenotypes. We focus specifically on dominance rank-associated dimensions of the social environment, including both competitive and affiliative interactions. Our results show that simple summaries of rank-associated behavioural interactions are often better predictors of molecular and physiological outcomes than dominance rank itself. However, while measures of immune function are best explained by agonism rates, glucocorticoid-related phenotypes tend to be more closely linked to affiliative behaviour. We conclude that dominance rank serves as a useful summary for investigating social environmental effects on downstream outcomes. Nevertheless, the behavioural interactions that define an individual's daily experiences reveal the proximate drivers of social status-related differences and are especially relevant for understanding why individuals who share the same social status sometimes appear physiologically distinct.This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.
DOI: 10.6084/m9.figshare.20296776
title: E.m SSR genotypes

description: Genotyping allele dataset of 10 microsatellite loci for <em>Eremias multiocellata. </em>Population information are also included.
DOI: 10.6084/m9.figshare.19767973.v1
title: Additional file 5 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 5. A total of 35225 lncRNA pairs were constructed.
DOI: 10.6084/m9.figshare.19767967
title: Additional file 3 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 3. A total of 1105 immune-related lncRNAs were identified by co-expression analysis.
DOI: 10.6084/m9.figshare.19767964
title: Additional file 2 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 2. A total of 1710 immune-related mRNAs were identified.
DOI: 10.6084/m9.figshare.19767970
title: Additional file 4 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 4. A total of 301 differently expressed immune-related lncRNAs were identified.
DOI: 10.6084/m9.figshare.19767964.v1
title: Additional file 2 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 2. A total of 1710 immune-related mRNAs were identified.
DOI: 10.6084/m9.figshare.19767994
title: Additional file 6 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 6: Supplementary file 4. The table of function predictions generated by the Tax4Fun2 program.
DOI: 10.6084/m9.figshare.19767970.v1
title: Additional file 4 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 4. A total of 301 differently expressed immune-related lncRNAs were identified.
DOI: 10.6084/m9.figshare.19767982.v1
title: Additional file 2 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 2: Supplementary file 1. Normalized OTU table. The table includes the information of OTU ID, abundance, and taxonomic assignment for each OTU.
DOI: 10.6084/m9.figshare.19767982
title: Additional file 2 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 2: Supplementary file 1. Normalized OTU table. The table includes the information of OTU ID, abundance, and taxonomic assignment for each OTU.
DOI: 10.6084/m9.figshare.19767967.v1
title: Additional file 3 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 3. A total of 1105 immune-related lncRNAs were identified by co-expression analysis.
DOI: 10.6084/m9.figshare.12579155
title: Potentilla_anserina_contig.fa

description: De novo genome assembly was performed using FALCON assembler. Firstly, the qualified PacBio subreads were self corrected through pre-assembled sequence. Then, overlapping was detected and filtrated for graph construction. Finally, contigs were generated using graph.
DOI: 10.6084/m9.figshare.25015854
title: LncRNA NEAT1 aggravates human microvascular endothelial cell injury by inhibiting the Apelin/Nrf2/HO-1 signalling pathway in type 2 diabetes mellitus with obstructive sleep apnoea

description: Long noncoding RNAs (lncRNAs) regulate the progression of type 2 diabetes mellitus complicated with obstructive sleep apnoea (T2DM-OSA). However, the role of the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in T2DM-OSA remains unknown. This study aimed to reveal the function of NEAT1 in T2DM-OSA and the underlying mechanism. KKAy mice were exposed to intermittent hypoxia (IH) or intermittent normoxia to generate a T2DM-OSA mouse model. HMEC-1 cells were treated with high glucose (HG) and IH to construct a T2DM-OSA cell model. RNA expression was detected by qRT-PCR. The protein expression of Apelin, NF-E2-related factor 2 (Nrf2), haem oxygenase-1 (HO-1), and up-frameshift suppressor 1 (UPF1) was assessed using western blot. Cell injury was evaluated using flow cytometry, enzyme-linked immunosorbent assay, and oxidative stress kit assays. RIP, RNA pull-down, and actinomycin D assays were performed to determine the associations between NEAT1, UPF1, and Apelin. NEAT1 expression was upregulated in the aortic vascular tissues of mice with T2DM exposed to IH and HMEC-1 cells stimulated with HG and IH, whereas Apelin expression was downregulated. The absence of NEAT1 protected HMEC-1 cells from HG- and IH-induced damage. Furthermore, NEAT1 destabilized Apelin mRNA by recruiting UPF1. Apelin overexpression decreased HG- and IH-induced injury to HMEC-1 cells by activating the Nrf2/HO-1 pathway. Moreover, NEAT1 knockdown reduced HG- and IH-induced injury to HMEC-1 cells through Apelin. NEAT1 silencing reduced HMEC-1 cell injury through the Apelin/Nrf2/HO-1 signalling pathway in T2DM-OSA. <b>Abbreviations:</b> LncRNAs, long non-coding RNAs; T2DM, type 2 diabetes mellitus; OSA, obstructive sleep apnoea; NEAT1, nuclear paraspeckle assembly transcript 1; IH, intermittent hypoxia; HMEC-1, human microvascular endothelial cells; HG, high glucose; Nrf2, NF-E2-related factor 2; UPF1, up-frameshift suppressor 1; HO-1, haem oxygenase-1; qRT-PCR, quantitative real-time polymerase chain reaction; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; TNF-α, tumour necrosis factor-α; CCK-8, Cell Counting Kit-8; IL-1β, interleukin-1β; ROS, reactive oxygen species; MDA, malondialdehyde; SOD, superoxide dismutase; RIP, RNA immunoprecipitation; SD, standard deviations; GSH, glutathione; AIS, acute ischaemic stroke; HMGB1, high mobility group box-1 protein; TLR4, toll-like receptor 4.
DOI: 10.6084/m9.figshare.25015854.v1
title: LncRNA NEAT1 aggravates human microvascular endothelial cell injury by inhibiting the Apelin/Nrf2/HO-1 signalling pathway in type 2 diabetes mellitus with obstructive sleep apnoea

description: Long noncoding RNAs (lncRNAs) regulate the progression of type 2 diabetes mellitus complicated with obstructive sleep apnoea (T2DM-OSA). However, the role of the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in T2DM-OSA remains unknown. This study aimed to reveal the function of NEAT1 in T2DM-OSA and the underlying mechanism. KKAy mice were exposed to intermittent hypoxia (IH) or intermittent normoxia to generate a T2DM-OSA mouse model. HMEC-1 cells were treated with high glucose (HG) and IH to construct a T2DM-OSA cell model. RNA expression was detected by qRT-PCR. The protein expression of Apelin, NF-E2-related factor 2 (Nrf2), haem oxygenase-1 (HO-1), and up-frameshift suppressor 1 (UPF1) was assessed using western blot. Cell injury was evaluated using flow cytometry, enzyme-linked immunosorbent assay, and oxidative stress kit assays. RIP, RNA pull-down, and actinomycin D assays were performed to determine the associations between NEAT1, UPF1, and Apelin. NEAT1 expression was upregulated in the aortic vascular tissues of mice with T2DM exposed to IH and HMEC-1 cells stimulated with HG and IH, whereas Apelin expression was downregulated. The absence of NEAT1 protected HMEC-1 cells from HG- and IH-induced damage. Furthermore, NEAT1 destabilized Apelin mRNA by recruiting UPF1. Apelin overexpression decreased HG- and IH-induced injury to HMEC-1 cells by activating the Nrf2/HO-1 pathway. Moreover, NEAT1 knockdown reduced HG- and IH-induced injury to HMEC-1 cells through Apelin. NEAT1 silencing reduced HMEC-1 cell injury through the Apelin/Nrf2/HO-1 signalling pathway in T2DM-OSA. <b>Abbreviations:</b> LncRNAs, long non-coding RNAs; T2DM, type 2 diabetes mellitus; OSA, obstructive sleep apnoea; NEAT1, nuclear paraspeckle assembly transcript 1; IH, intermittent hypoxia; HMEC-1, human microvascular endothelial cells; HG, high glucose; Nrf2, NF-E2-related factor 2; UPF1, up-frameshift suppressor 1; HO-1, haem oxygenase-1; qRT-PCR, quantitative real-time polymerase chain reaction; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; TNF-α, tumour necrosis factor-α; CCK-8, Cell Counting Kit-8; IL-1β, interleukin-1β; ROS, reactive oxygen species; MDA, malondialdehyde; SOD, superoxide dismutase; RIP, RNA immunoprecipitation; SD, standard deviations; GSH, glutathione; AIS, acute ischaemic stroke; HMGB1, high mobility group box-1 protein; TLR4, toll-like receptor 4.
DOI: 10.6084/m9.figshare.12579158
title: Potentilla_anserina.agp.out

description: agp file of Potentilla anserina genome
DOI: 10.6084/m9.figshare.19767973
title: Additional file 5 of An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

description: Additional file 5. A total of 35225 lncRNA pairs were constructed.
DOI: 10.6084/m9.figshare.19767955.v1
title: Additional file 7 of Diabetes risk loci-associated pathways are shared across metabolic tissues

description: Additional file 7: Table S6. Enriched REACTOME pathways based on T2D SNPs.
DOI: 10.6084/m9.figshare.19767952.v1
title: Additional file 6 of Diabetes risk loci-associated pathways are shared across metabolic tissues

description: Additional file 6: Table S5. Enriched KEGG pathways based on T2D SNPs.
DOI: 10.6084/m9.figshare.19767988
title: Additional file 4 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 4: Supplementary file 2. SparCC table. Table of calculated SparCC correlations and pseudo p-values for 61 OTUs that had strong correlations with at least one other OTU.
DOI: 10.25402/cer.16627531
title: Supplementary Table 1. Off-label antipsychotic use patterns among Texas Medicaid adults 2013–2016

description: Supplementary Table 1: Diagnosis and ICD-9-CM, ICD-10-CM Codes
DOI: 10.6084/m9.figshare.19767991
title: Additional file 5 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 5: Supplementary file 3. Taxonomic table. Table of taxonomic classification of 61 strongly correlated OTUs.
DOI: 10.6084/m9.figshare.19767991.v1
title: Additional file 5 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 5: Supplementary file 3. Taxonomic table. Table of taxonomic classification of 61 strongly correlated OTUs.
DOI: 10.6084/m9.figshare.19767988.v1
title: Additional file 4 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 4: Supplementary file 2. SparCC table. Table of calculated SparCC correlations and pseudo p-values for 61 OTUs that had strong correlations with at least one other OTU.
DOI: 10.6084/m9.figshare.19767994.v1
title: Additional file 6 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 6: Supplementary file 4. The table of function predictions generated by the Tax4Fun2 program.
DOI: 10.6084/m9.figshare.19767997
title: Additional file 7 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 7: Supplementary file 5. The table of pathway predictions generated by the Tax4Fun2 program.
DOI: 10.6084/m9.figshare.19767997.v1
title: Additional file 7 of Dynamic changes in fecal bacterial microbiota of dairy cattle across the production line

description: Additional file 7: Supplementary file 5. The table of pathway predictions generated by the Tax4Fun2 program.
DOI: 10.6084/m9.figshare.19768000
title: Additional file 1 of Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers

description: Additional file 1. List of complete GO-terms relating to both significantly increased and decreased proteins (clinical AD vs. control) in EMIF-AD. Description of data: GO biological process terms were generated with the PANTHER statistical overrepresentation test. For significantly increased proteins, an FDR-correction was performed.
DOI: 10.6084/m9.figshare.19768024
title: Additional file 2 of Association between early ondansetron administration and in-hospital mortality in critically ill patients: analysis of the MIMIC-IV database

description: Additional file 2: Table S1. Percentage of missing data in the variables in the interest.
DOI: 10.6084/m9.figshare.19768024.v1
title: Additional file 2 of Association between early ondansetron administration and in-hospital mortality in critically ill patients: analysis of the MIMIC-IV database

description: Additional file 2: Table S1. Percentage of missing data in the variables in the interest.
DOI: 10.6084/m9.figshare.19768100.v1
title: Additional file 4 of RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma

description: Additional file 4: Supplementary Table S2. Immunohistochemistry score of RNF38 expression in nasopharyngeal carcinoma and normal nasopharyngeal epithelia tissues.
DOI: 10.6084/m9.figshare.19768106.v1
title: Additional file 6 of RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma

description: Additional file 6: Supplementary Table S4. Proteins that specially enriched by RNF38 in SUNE-1 and CEN-2 cells. (XLS 67 kb)
DOI: 10.25549/whit-c170-105790
title: [Hollywood Park Racetrack before opening], Inglewood, Calif., 1938

description: 13 photographs of the empty racetrack and buildings before the Hollywood Park Racetrack opened on June 10, Inglewood, California, 1938 June.
DOI: 10.25549/whit-c170-105798
title: [Hollywood Park Racetrack before opening], Inglewood, Calif., 1938

description: 13 photographs of the empty racetrack and buildings before the Hollywood Park Racetrack opened on June 10, Inglewood, California, 1938 June.
DOI: 10.15468/dl.vjptzc
title: Occurrence Download

description: A dataset containing 23 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Meriania robusta Cogn.",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 23 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093127-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-105801
title: [Hollywood Park Racetrack before opening], Inglewood, Calif., 1938

description: 13 photographs of the empty racetrack and buildings before the Hollywood Park Racetrack opened on June 10, Inglewood, California, 1938 June.
DOI: 10.15468/dl.k3jqac
title: Occurrence Download

description: A dataset containing 8072 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Alibertia edulis (Rich.) A.Rich. ex DC."
 ]
}

 The dataset includes 8072 records from 300 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005993-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z4ft27
title: Occurrence Download

description: A dataset containing 1977 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ambrosia artemisiifolia L.",
 "HasGeospatialIssue is false",
 "Geometry POLYGON((-30.94 -4.81,-30.94 79.26,-170.51 79.26,-170.51 -4.81,-30.94 -4.81))"
 ]
}

 The dataset includes 1977 records from 76 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093128-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-105570
title: [Shriners event at Los Angeles Memorial Coliseum], Los Angeles, Calif., 1938

description: 46 photographs of the Shriners convention at the Los Angeles Memorial Coliseum, Los Angeles, California, 1938 June. There are parade floats representing contingents of Shriners from different parts of the USA, clown cars, officials, bands, cannons, automobiles, a military group, and behind-the-scenes areas of the Coliseum. One photograph shows officials on a stand speaking into a microphone from Radio Station KEHE. Editor's note: the photographer's job number does not specify a date for this event. The Shriners convention lasted from June 7 through June 9.
DOI: 10.25549/whit-c170-73246
title: San Marino Woods, Southern California, 1927

description: 8 photographs of San Marino Woods, Southern California, 1927. "73-23-92 1927; Case & Hughes; San Marino Woods; San Marino school" -- on envelope.
DOI: 10.15468/dl.3iyoaw
title: Occurrence Download

description: A dataset containing 455 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is SIO_FAMIZ"
 ]
}

 The dataset includes 455 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093129-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-110513
title: Dick Whittington Photography Collection, 1924-1987
DOI: 10.15468/dl.gmvcie
title: Occurrence Download

description: A dataset containing 161 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aniba perutilis Hemsl.",
 "Country is Colombia"
 ]
}

 The dataset includes 161 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093131-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.