cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9871712
title: Influence of Sintering Time on the PTCR Effect of Nb2O5-doped BaTiO3 Ceramics

description: The effects of the sintering time on the electrical properties and the positive temperature coefficient of resistance (PTCR) effect of Ba1.006(Ti1-xNbx)O3 (BTN) ceramics were investigated, which were sintered at 1190 ºC for 0.5-6 hours in a reducing atmosphere and then re-oxidized at 800 ºC for 1 hour. The results indicated that the sintering time affected the electrical properties and the PTCR effect of the multilayer BTN samples, whose room-temperature resistance decreased with an increase of the sintering time at same sintering temperature of 1190 ºC. However, the resistance jump first increased and then reduced as a function of the sintering time. Furthermore, The BTN ceramics exhibited a pronounced PTCR effect, with a resistance jump greater by 3.6 orders of magnitude, along with a low RT resistance of 0.14 Ω at a reoxidated temperature of 800 ºC after sintering at 1190 ºC for 2 h in a reducing atmosphere. In addition, the activation energy of samples obtained at different sintering times had also been investigated.
DOI: 10.6084/m9.figshare.9871712.v1
title: Influence of Sintering Time on the PTCR Effect of Nb2O5-doped BaTiO3 Ceramics

description: The effects of the sintering time on the electrical properties and the positive temperature coefficient of resistance (PTCR) effect of Ba1.006(Ti1-xNbx)O3 (BTN) ceramics were investigated, which were sintered at 1190 ºC for 0.5-6 hours in a reducing atmosphere and then re-oxidized at 800 ºC for 1 hour. The results indicated that the sintering time affected the electrical properties and the PTCR effect of the multilayer BTN samples, whose room-temperature resistance decreased with an increase of the sintering time at same sintering temperature of 1190 ºC. However, the resistance jump first increased and then reduced as a function of the sintering time. Furthermore, The BTN ceramics exhibited a pronounced PTCR effect, with a resistance jump greater by 3.6 orders of magnitude, along with a low RT resistance of 0.14 Ω at a reoxidated temperature of 800 ºC after sintering at 1190 ºC for 2 h in a reducing atmosphere. In addition, the activation energy of samples obtained at different sintering times had also been investigated.
DOI: 10.6084/m9.figshare.8298869
title: Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort

description: The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that <i>in utero</i> and early life conditions can disrupt normal fetal development and program susceptibility to later-life disease. Metastable epialleles are genomic loci in which CpG methylation patterning is responsive to maternal diet and conserved across time and tissues. Thus, these sites could serve as ‘signatures’ of gestational environment conditions. Here, we sought to determine if methylation of metastable epialleles was associated with changes in childhood body mass index (BMI) z-scores across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort. CpG methylation of 250 probes (corresponding to 111 genes) within metastable epiallele regions was measured in placental tissue. Linear mixed effects models were fit to evaluate the overall and sex-stratified associations between methylation and changes in BMI z-score over time. In total, 26 probes were associated (<i>p</i> &lt; 0.05) with changes in BMI z-score overall, including probes within Mesoderm Specific Transcript <i>(MEST)</i> and Histone Deacetylase 4 (<i>HDAC4</i>), which have previously been associated with childhood obesity and adipogenesis. Sex-stratified analyses revealed a significant association, after adjusting for multiple comparisons (<i>q</i> &lt; 0.05), within female placentas for one probe annotated to the imprinted gene PLAG1 Like Zinc Finger 1 (<i>PLAGL1)</i>. These findings suggest epigenetic marks may be involved in programming susceptibility to obesity <i>in utero</i> and highlight the potential to use placental tissues in predicting growth rate trajectories among premature infants.
DOI: 10.6084/m9.figshare.8298869.v2
title: Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort

description: The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that <i>in utero</i> and early life conditions can disrupt normal fetal development and program susceptibility to later-life disease. Metastable epialleles are genomic loci in which CpG methylation patterning is responsive to maternal diet and conserved across time and tissues. Thus, these sites could serve as ‘signatures’ of gestational environment conditions. Here, we sought to determine if methylation of metastable epialleles was associated with changes in childhood body mass index (BMI) z-scores across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort. CpG methylation of 250 probes (corresponding to 111 genes) within metastable epiallele regions was measured in placental tissue. Linear mixed effects models were fit to evaluate the overall and sex-stratified associations between methylation and changes in BMI z-score over time. In total, 26 probes were associated (<i>p</i> &lt; 0.05) with changes in BMI z-score overall, including probes within Mesoderm Specific Transcript <i>(MEST)</i> and Histone Deacetylase 4 (<i>HDAC4</i>), which have previously been associated with childhood obesity and adipogenesis. Sex-stratified analyses revealed a significant association, after adjusting for multiple comparisons (<i>q</i> &lt; 0.05), within female placentas for one probe annotated to the imprinted gene PLAG1 Like Zinc Finger 1 (<i>PLAGL1)</i>. These findings suggest epigenetic marks may be involved in programming susceptibility to obesity <i>in utero</i> and highlight the potential to use placental tissues in predicting growth rate trajectories among premature infants.
DOI: 10.6084/m9.figshare.8298869.v1
title: Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort

description: The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that <i>in utero</i> and early life conditions can disrupt normal fetal development and program susceptibility to later-life disease. Metastable epialleles are genomic loci in which CpG methylation patterning is responsive to maternal diet and conserved across time and tissues. Thus, these sites could serve as ‘signatures’ of gestational environment conditions. Here, we sought to determine if methylation of metastable epialleles was associated with changes in childhood body mass index (BMI) z-scores across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort. CpG methylation of 250 probes (corresponding to 111 genes) within metastable epiallele regions was measured in placental tissue. Linear mixed effects models were fit to evaluate the overall and sex-stratified associations between methylation and changes in BMI z-score over time. In total, 26 probes were associated (<i>p</i> &lt; 0.05) with changes in BMI z-score overall, including probes within Mesoderm Specific Transcript <i>(MEST)</i> and Histone Deacetylase 4 (<i>HDAC4</i>), which have previously been associated with childhood obesity and adipogenesis. Sex-stratified analyses revealed a significant association, after adjusting for multiple comparisons (<i>q</i> &lt; 0.05), within female placentas for one probe annotated to the imprinted gene PLAG1 Like Zinc Finger 1 (<i>PLAGL1)</i>. These findings suggest epigenetic marks may be involved in programming susceptibility to obesity <i>in utero</i> and highlight the potential to use placental tissues in predicting growth rate trajectories among premature infants.
DOI: 10.6084/m9.figshare.6726065
title: Public FA Data.xlsx

description: This database contains all variables used in the analysis of the association between symptoms of food addiction and various metabolic characteristics including insulin resistance and lipid profiles in the general Newfoundland population<br>
DOI: 10.25403/upresearchdata.25217603.v1
title: Data score sheets of the Walker (2008) and Phenice (1969) traits from Pretoria Bone Collection and Raymond A. Dart Collection of Modern Human Skeletons to estimate sex from skeletal remains

description: Forensic anthropologists are often required to establish a biological profile from skeletal remains, which includes the estimation of biological sex. The Walker and Phenice traits are morphoscopic methods frequently utilised to estimate sex from unknown skeletal remains. The methods employ five traits located on the skull and three on the Os coxae and are considered the classic morphological skeletal sex indicators. Previous literature has stated that the growth and deterioration related to aging that occurs throughout an individual’s life may affect the classic morphological skeletal sex indicators and therefore the estimation of sex. More specifically, females are reported to become more robust with older age, while younger males appear more gracile. This overlap in sexual dimorphism leads to greater misclassification and decreased accuracy in medicolegal casework. The aim of this study was to assess if age needs to be considered when attempting to classify sex using the classic morphological sex indicators.The sex indicators were scored on a sample of 453 skulls and 429 Os coxae of modern South Africans. The scores were then compared among ten different age cohorts. Separate age-specific classification models were created to assess if age affects the positive predictive performance of the sample. Significant differences were identified for the nuchal crest between age cohorts younger and older than forty years of age with the sample pooled. None of the other cranial traits demonstrated any significant differences. Regarding the classification models, accuracies increased for the younger group when separated from the older group, but the opposite was shown to be true for the older group. The Os coxae did not show significant differences between the ten age cohorts. However, when separated into three large cohorts (younger, middle-aged, older) differences in accuracy was apparent between the cohorts. The results indicate that preselection of age prior to sex estimation is not necessary in a South African population. Further research is required to identify additional explanations for misclassification with sex estimation, as age does not appear to be a major influential factor for the classic morphoscopic sex indicators.
DOI: 10.25403/upresearchdata.25217603
title: Data score sheets of the Walker (2008) and Phenice (1969) traits from Pretoria Bone Collection and Raymond A. Dart Collection of Modern Human Skeletons to estimate sex from skeletal remains

description: Forensic anthropologists are often required to establish a biological profile from skeletal remains, which includes the estimation of biological sex. The Walker and Phenice traits are morphoscopic methods frequently utilised to estimate sex from unknown skeletal remains. The methods employ five traits located on the skull and three on the Os coxae and are considered the classic morphological skeletal sex indicators. Previous literature has stated that the growth and deterioration related to aging that occurs throughout an individual’s life may affect the classic morphological skeletal sex indicators and therefore the estimation of sex. More specifically, females are reported to become more robust with older age, while younger males appear more gracile. This overlap in sexual dimorphism leads to greater misclassification and decreased accuracy in medicolegal casework. The aim of this study was to assess if age needs to be considered when attempting to classify sex using the classic morphological sex indicators.The sex indicators were scored on a sample of 453 skulls and 429 Os coxae of modern South Africans. The scores were then compared among ten different age cohorts. Separate age-specific classification models were created to assess if age affects the positive predictive performance of the sample. Significant differences were identified for the nuchal crest between age cohorts younger and older than forty years of age with the sample pooled. None of the other cranial traits demonstrated any significant differences. Regarding the classification models, accuracies increased for the younger group when separated from the older group, but the opposite was shown to be true for the older group. The Os coxae did not show significant differences between the ten age cohorts. However, when separated into three large cohorts (younger, middle-aged, older) differences in accuracy was apparent between the cohorts. The results indicate that preselection of age prior to sex estimation is not necessary in a South African population. Further research is required to identify additional explanations for misclassification with sex estimation, as age does not appear to be a major influential factor for the classic morphoscopic sex indicators.
DOI: 10.6084/m9.figshare.8298965
title: Additional file 4: of Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

description: Table S1. Tumor volumes of subcutaneous xenograft nude mice models in control group and TOP2A knockdown group. This table included the diameter and volume of the tumor sizes in control group and TOP2A knockdown group, which were measured as indicated in the methods section. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8298965.v1
title: Additional file 4: of Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

description: Table S1. Tumor volumes of subcutaneous xenograft nude mice models in control group and TOP2A knockdown group. This table included the diameter and volume of the tumor sizes in control group and TOP2A knockdown group, which were measured as indicated in the methods section. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8298968
title: MOESM1 of Differential motility parameters and identification of proteomic profiles of human sperm cryopreserved with cryostraw and cryovial

description: Additional file 1: Table S1. Total of proteins were identified in human sperm.
DOI: 10.6084/m9.figshare.8298968.v1
title: MOESM1 of Differential motility parameters and identification of proteomic profiles of human sperm cryopreserved with cryostraw and cryovial

description: Additional file 1: Table S1. Total of proteins were identified in human sperm.
DOI: 10.6084/m9.figshare.8298974
title: MOESM2 of Differential motility parameters and identification of proteomic profiles of human sperm cryopreserved with cryostraw and cryovial

description: Additional file 2: Table S2. The differentially identified human sperm proteins.
DOI: 10.6084/m9.figshare.8298974.v1
title: MOESM2 of Differential motility parameters and identification of proteomic profiles of human sperm cryopreserved with cryostraw and cryovial

description: Additional file 2: Table S2. The differentially identified human sperm proteins.
DOI: 10.6084/m9.figshare.25288510
title: Supplementary Material for: Personalized Paths: Unlocking Alzheimer's via the Gut-Brain Axis

description: Background: Alzheimer's disease is characterised by abnormal protein aggregates in the brain that lead to cognitive decline. While current therapies only treat symptoms, disease-modifying treatments are urgently needed. Studies suggest that the composition of the microbiota is altered in people with Alzheimer's disease (AD), suggesting a link between gut bacteria and AD-related brain changes. 
Summary: In our narrative review, we explore various microbial interventions, such as faecal microbiota transplantation (FMT), probiotics and diet, as powerful potential treatments. Studies suggest changes in microbiota composition following these interventions, with some beneficial effects on cognitive function. However, the mechanism of action of these microbial interventions is still unknown.
Key message: Our aim here is to highlight the importance of personalised approaches, taking into account individual metabolic and microbiome profiles. We try to address gaps in current research and emphasise the need for microbiota analysis at different stages of the disease and its integration with clinical parameters and lifestyle information for a comprehensive understanding of AD progression (summarised in Figure 1).
DOI: 10.5281/zenodo.10707586
title: Investigating the Water Availability Hypothesis of Pot Binding: Small Pots and Infrequent Irrigation Confound the Effects of Drought Stress in Potato (Solanum tuberosum L.) Data

description: To maximise the throughput of novel, high-throughput phenotyping platforms, many researchers have utilised smaller pot sizes to increase the number of biological replicates that can be grown in spatially limited controlled environments. This may confound plant development through a process known as “pot binding”, particularly in larger species including potato (Solanum tuberosum), and under water-restricted conditions. We aimed to investigate the water availability hypothesis of pot binding, which predicts that small pots have insufficient water holding capacities to prevent drought stress between irrigation periods, in potato. Two cultivars of potato were grown in small (5 L) and large (20 L) pots under glasshouse conditions and were subjected to three irrigation frequencies: every other day, daily, and twice daily. Plants were phenotyped with two Phenospex PlantEye F500s and canopy and tuber fresh mass and dry matter were measured. Increasing irrigation frequency from every other day to daily was associated with a significant increase in fresh tuber yield, but only in large pots. This suggests a similar level of drought stress occurred between these treatments in the small pots, supporting the water availability hypothesis of pot binding. Further increasing irrigation frequency to twice daily was still not sufficient to increase yields in small pots but caused an insignificant increase in yield in the larger pots, suggesting some pot binding may be occurring in large pots under daily irrigation. Canopy temperatures were significantly higher under each irrigation frequency in the small pots compared to large pots, which strongly supports the water availability hypothesis as higher canopy temperatures are a reliable indicator of drought stress in potato. Digital phenotyping was found to be less accurate for larger plants, probably due to a higher degree of self-shading. The research demonstrates the need to define the optimum pot size and irrigation protocols required to completely prevent pot binding and ensure drought treatments are not inadvertently applied to control plants.
DOI: 10.5281/zenodo.10707587
title: Investigating the Water Availability Hypothesis of Pot Binding: Small Pots and Infrequent Irrigation Confound the Effects of Drought Stress in Potato (Solanum tuberosum L.) Data

description: To maximise the throughput of novel, high-throughput phenotyping platforms, many researchers have utilised smaller pot sizes to increase the number of biological replicates that can be grown in spatially limited controlled environments. This may confound plant development through a process known as “pot binding”, particularly in larger species including potato (Solanum tuberosum), and under water-restricted conditions. We aimed to investigate the water availability hypothesis of pot binding, which predicts that small pots have insufficient water holding capacities to prevent drought stress between irrigation periods, in potato. Two cultivars of potato were grown in small (5 L) and large (20 L) pots under glasshouse conditions and were subjected to three irrigation frequencies: every other day, daily, and twice daily. Plants were phenotyped with two Phenospex PlantEye F500s and canopy and tuber fresh mass and dry matter were measured. Increasing irrigation frequency from every other day to daily was associated with a significant increase in fresh tuber yield, but only in large pots. This suggests a similar level of drought stress occurred between these treatments in the small pots, supporting the water availability hypothesis of pot binding. Further increasing irrigation frequency to twice daily was still not sufficient to increase yields in small pots but caused an insignificant increase in yield in the larger pots, suggesting some pot binding may be occurring in large pots under daily irrigation. Canopy temperatures were significantly higher under each irrigation frequency in the small pots compared to large pots, which strongly supports the water availability hypothesis as higher canopy temperatures are a reliable indicator of drought stress in potato. Digital phenotyping was found to be less accurate for larger plants, probably due to a higher degree of self-shading. The research demonstrates the need to define the optimum pot size and irrigation protocols required to completely prevent pot binding and ensure drought treatments are not inadvertently applied to control plants.
DOI: 10.6084/m9.figshare.7774823
title: Additional file 2: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S1. ClearSeq Cancer Panel Gene List. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7774823.v1
title: Additional file 2: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S1. ClearSeq Cancer Panel Gene List. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7774832
title: Additional file 3: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S2. DNA sequencing primer. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7774832.v1
title: Additional file 3: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S2. DNA sequencing primer. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7774844
title: Additional file 4: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S3. Patient characteristics. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7774844.v1
title: Additional file 4: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S3. Patient characteristics. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.7774856
title: Additional file 5: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S4. Reproducibility of targeted deep sequencing without MBS. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.7774856.v1
title: Additional file 5: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S4. Reproducibility of targeted deep sequencing without MBS. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.7774871
title: Additional file 7: of Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naĂŻve lung adenocarcinoma

description: Table S5. Patient characteristics. (XLSX 10 kb)