cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.5hqbzkh9s
title: Health records from hospitalized adults with malaria during 2019 at Bo Government Hospital, Sierra Leone

description: We performed a chart review of adults admitted to Bo Government Hospital
 during 2019. Of 893 admissions,149 (59% female, mean age 58.5 years) had a
 laboratory diagnosis of malaria and 22 (14.8%) died. Mortality was
 significantly higher among patients with severe malaria compared with
 those who had non-severe malaria (6/20 [30%] versus 16/129
 [12.4%], p=0.031). Our data suggest that malaria is a common
 cause of death in hospitalized Sierra Leonean adults.  
description: A retrospective chart review was
 conducted. Data were extracted from the
 medical charts of adults admitted to one of three adult medical wards
 during 2019. Collected data were entered into a spreadsheet, including
 age, sex, results of diagnostic testing for malaria, information on the
 severity of malaria, and patient outcome.
description: Any software that can accommodate datasets in csv format can be
 used to open the data files.
DOI: 10.5061/dryad.jm63xsjg0
title: Different waves of postglacial recolonisation and genomic structure of bank vole population in NE Poland

description: Previous studies indicated that in some species phylogeographic patterns
 obtained in analyses of nuclear and mitochondrial DNA (mtDNA) markers can
 be different. Such mitonuclear discordance can have important evolutionary
 and ecological consequences. In the present study, we aimed to check if
 there was any discordance between mitochondrial and nuclear DNA in the
 bank vole population in the contact zone of its two mtDNA lineages. We
 analysed the population genetic structure of bank voles using genome-wide
 genetic data (SNPs) and diversity of sequenced heart transcriptomes
 obtained from selected individuals from three populations inhabiting areas
 outside the contact zone. The SNP genetic structure of the populations
 confirmed the presence of at least two genetic clusters, and such division
 was concordant with the patterns obtained in analyses of other genetic
 markers and functional genes. However, genome-wide SNP analyses revealed a
 more detailed structure of the studied population, consistent with more
 than two bank vole recolonisation waves, as previously recognised in the
 study area. We did not find any significant differences between
 individuals representing two separate mtDNA lineages of the species in
 functional genes coding for protein-forming complexes, which are involved
 in the process of cell respiration in mitochondria. We concluded that the
 contemporary genetic structure of the populations and the width of the
 contact zone were shaped by climatic and environmental factors rather than
 by genetic barriers. The studied populations were likely isolated in
 separate Last Glacial Maximum refugia for an insufficient amount of time
 to develop significant genetic differentiation.
DOI: 10.5061/dryad.ffbg79d03
title: Low Kirtland’s Warbler fledgling survival in Wisconsin plantations relative to Michigan plantations

description: The Kirtland’s Warbler (Setophaga kirtlandii) is a formerly endangered
 habitat specialist that breeds mainly in young jack pine (Pinus banksiana)
 forests in northern Lower Michigan, USA. The species is
 conservation-reliant and depends on habitat management. Management actions
 have primarily focused on creating jack pine plantations, but the species
 also breeds in red pine (Pinus resinosa) plantations in central Wisconsin,
 USA. However, the plantations were not intended as breeding habitat and
 have suboptimal pine densities. While nesting success is similar between
 low-density red pine plantations and optimal jack pine habitat, it is not
 clear if low-density red pine plantations support high fledging survival.
 If high-quality nesting and post-fledging habitat are not synonymous,
 fledgling survival and breeding population recruitment may be low. We
 characterized survival, habitat use, and movement patterns of dependent
 Kirtland’s Warbler fledglings in Wisconsin red pine plantations and
 compared fledgling survival between Wisconsin and Michigan. Mayfield
 cumulative survival estimates at 30 days post-fledging were 0.20 for
 Wisconsin fledglings and 0.43 to 0.78 for Michigan fledglings. Logistic
 exposure cumulative survival estimates for Wisconsin fledglings were 0.23
 to 0.34 at 30 days post-fledging. Fledglings in Wisconsin used areas where
 vegetation cover and density of red and jack pine were high relative to
 available areas but not at greater proportions than what was available.
 Our findings demonstrate that red pine plantations with low pine densities
 were not equally suitable as nesting and post-fledging habitat, as
 fledgling survival rates were low. We hypothesize that habitat structure,
 and not particular pine species, likely contributed to reduced fledgling
 survival in Wisconsin. Thus, we recommend including red pine as a
 component in managed Kirtland’s Warbler habitat only if tree densities
 approach optimal levels.
description: These data were collected using through radio-telemetry and field
 vegetation sampling in Adams County, Wisconsin. Fledgling Kirtland's
 Warblers were radio-tagged and radio-tracked daily. Vegetation data was
 collected at fledgling locations and areas not used by fledglings.
 Fledgling survival was modeled using logistic exposure models and Mayfield
 survival estimation. Habitat use was modeled using logistic regression.
 All analyses were conducted in the R Statistical Environment to produce a
 manuscript accepted for publication by Ornithological
 Applications.
DOI: 10.5061/dryad.18931zd29
title: Phylogenetic analyses of the MopB superfamily

description: The Dimethyl Sulfoxide Reductase (or MopB) family is a diverse assemblage
 of enzymes found throughout Bacteria and Archaea.  Many of these
 enzymes are believed to have been present in the last universal common
 ancestor (LUCA) of all cellular lineages.  However, gaps in
 knowledge remain on how MopB enzymes evolved and how this diversification
 of functions impacted global biogeochemical cycles through geologic
 time.  In this study, we perform maximum likelihood phylogenetic
 analyses on manually curated comparative genomic and metagenomic datasets
 containing over 47,000 distinct MopB homologs.  We demonstrate
 that these enzymes constitute a catalytically and mechanistically diverse
 superfamily defined, not by the molybdo- or tungstopterin containing
 pterin (Mo/W-bisPGD) co-factor, but rather by the structural fold that
 binds it in the protein.  Our results suggest that major
 metabolic innovations were the result of the loss of the metal co-factor,
 or the gain or loss of protein domains.  Phylogenetic analyses
 also demonstrated that formate oxidation and CO2 reduction were
 the ancestral functions of the superfamily, traits that have been
 vertically inherited from LUCA.  Nearly all of the other
 families, which drive all other biogeochemical cycles mediated by this
 superfamily, originated in the bacterial domain.  Thus organisms
 from Bacteria have been the key drivers of catalytic and biogeochemical
 innovations within the superfamily.  The relative ordination of
 MopB families and their associated catalytic activities emphasize
 fundamental mechanisms of evolution in this superfamily.
  Further, it underscores the importance of prokaryotic
 adaptability in response to the transition from an anoxic to oxidized
 atmosphere.  
description: Genomics datasets were obtained using NCBI's DELTA-BLAST
 tool.  Analyses were restricted to phyla represented in the Integrated
 Microbial Genomics Encyclopedia of Bacteria and Archaea.  Metagenomic
 datasets were obtained from GTDB-TK.  All metagenomic dataset analyses
 were performed using a computing cluster.  BLASTx was used to find
 putative MopB superfamily members in the GTDB-TK dataset.
 All sequences were aligned using the online version of MAFFT. 
 Phylogenetic analyses of the metagenomic datasets were done using a
 reduced dataset generated by the CDHIT program.  We utilized the CDHIT 50
 setting.  All phylogenies and amino acid substitution model tests were
 done using IQTree.  All phylogenies were generated using a computing
 cluster.
description: All datafiles can be viewed using a standard text editor. 
 Sequence alignments and phylogenetic trees can be opened using any
 standard, open-source software programs for sequence and tree
 visualization.
DOI: 10.5061/dryad.g79cnp5v2
title: Asymmetric mechanotransduction by hair cells of the zebrafish lateral line (Part 2/2)

description: In the lateral line system, water motion is detected by neuromast organs,
 fundamental units that are arrayed on a fish’s surface. Each neuromast
 contains hair cells, specialized mechanoreceptors that convert mechanical
 stimuli, in the form of water movement, into electrical signals. The
 orientation of hair cells’ mechanosensitive structures ensures that the
 opening of mechanically-gated channels is maximal when deflected in a
 single direction. In each neuromast organ, hair cells have two opposing
 orientations, enabling bi-directional detection of water movement.
 Interestingly, Tmc2b and Tmc2a proteins, which constitute the
 mechanotransduction channels in neuromasts, distribute asymmetrically so
 that Tmc2a is expressed in hair cells of only one orientation. Here, using
 both in vivo recording of extracellular potentials and calcium imaging of
 neuromasts, we demonstrate that hair cells of one orientation have larger
 mechanosensitive responses. The associated afferent neuron processes that
 innervate neuromast hair cells faithfully preserve this functional
 difference. Moreover, Emx2, a transcription factor required for the
 formation of hair cells with opposing orientations, is necessary to
 establish this functional asymmetry within neuromasts. Remarkably, loss of
 Tmc2a does not impact hair cell orientation but abolishes the functional
 asymmetry as measured by recording extracellular potentials and calcium
 imaging. Overall, our work indicates that oppositely oriented hair cells
 within a neuromast employ different proteins to alter mechanotransduction
 to sense the direction of water motion.
description: Electrophysiology traces will require Clampfit or another
 equivalent program to open. Matlab can also be used.
DOI: 10.5061/dryad.c59zw3rcm
title: Code for the population genetic models of the evolution of preference strength

description: Sexual selection has a rich history of mathematical models that consider
 why preferences favor one trait phenotype over another (for population
 genetic models) or what specific trait value is preferred (for
 quantitative genetic models). Less common is exploration of the evolution
 of choosiness or preference strength: that is, by how much a trait is
 preferred. We examine both population and quantitative genetic models of
 the evolution of preferences, specifically developing “baseline models” of
 the evolution of preference strength during the Fisher process. Using a
 population genetic approach based on the classic model of Kirkpatrick
 (1982), we find selection for stronger and stronger preferences when trait
 variation is maintained by mutation. However, this force is quite weak and
 likely to be swamped by drift in moderately-sized populations. In a
 quantitative genetic model based on Lande (1981), unimodal preferences
 will generally not evolve to be increasingly strong without bounds when
 male traits are under stabilizing viability selection, but evolve to
 extreme values when viability selection is directional. Our results
 highlight that different shapes of fitness and preference functions lead
 to qualitatively different trajectories for preference strength evolution
 ranging from no evolution to extreme evolution of preference strength.
description: The dataset consists of Mathematica code used to develop and
 analyze the two locus model, the three locus model, and the model with
 finite population sizes in the accompanying paper.  It also contains a the
 quasi-linkage equilibrium analysis.
description: Mathematica is necessary, and a free reader for Mathematica is
 available online.
DOI: 10.5061/dryad.ffbg79d04
title: Data for: HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

description: The membrane-associated RING-CH-type finger ubiquitin ligase MARCHF8 is a
 human homolog of the viral ubiquitin ligases Kaposi’s sarcoma herpesvirus
 K3 and K5 that promote host immune evasion. Previous studies have shown
 that MARCHF8 ubiquitinates several immune receptors, such as the major
 histocompatibility complex II and CD86. While human papillomavirus (HPV)
 does not encode any ubiquitin ligase, the viral oncoproteins E6 and E7 are
 known to regulate host ubiquitin ligases. Here, we report that MARCHF8
 expression is upregulated in HPV-positive head and neck cancer (HNC)
 patients but not in HPV-negative HNC patients compared to normal
 individuals. The MARCHF8 promoter is highly activated by HPV oncoprotein
 E6-induced MYC/MAX transcriptional activation. The knockdown of MARCHF8
 expression in human HPV-positive HNC cells restores cell surface
 expression of the tumor necrosis factor receptor superfamily (TNFRSF)
 death receptors, FAS, TRAIL-R1, and TRAIL-R2, and enhances apoptosis.
 MARCHF8 protein directly interacts with and ubiquitinates the TNFRSF death
 receptors. Further, MARCHF8 knockout in mouse oral cancer cells expressing
 HPV16 E6 and E7 augments cancer cell apoptosis and suppresses tumor growth
 in vivo. Our findings suggest that HPV inhibits host cell apoptosis by
 upregulating MARCHF8 and degrading TNFRSF death receptors in HPV-positive
 HNC cells.
DOI: 10.5061/dryad.w9ghx3ft5
title: Interactive effects of elevated temperature and drought on plant carbon metabolism: A meta‐analysis

description: Elevated temperature (Te) and drought often co-occur and interactively
 affect plant carbon (C) metabolism and thus the ecosystem C cycling, but
 the magnitude of their interaction is unclear, making the projection of
 global change impacts challenging. Here, we compiled 107 journal articles
 in which temperature and water availability were jointly manipulated and
 performed a meta-analysis of interactive effects of Te and drought on leaf
 photosynthesis (Agrowth) and respiration (Rgrowth) at growth temperature,
 nonstructural carbohydrates and biomass of plants, and their dependencies
 on experimental and biological moderators (e.g., treatment intensity,
 plant functional type). Our results showed that, overall, there was no
 significant interaction of Te and drought on Agrowth. Te accelerated
 Rgrowth under well-watered conditions rather than under drought
 conditions. The Te × drought interaction on leaf soluble sugar and starch
 concentrations were neutral and negative, respectively. The effect of Te
 and drought on plant biomass displayed a negative interaction, with Te
 deteriorating the drought impacts. Drought induced an increase in
 root-to-shoot ratio at ambient temperature but not at Te. The magnitudes
 of Te and drought negatively modulated the Te drought interactions on
 Agrowth. Root biomass of woody plants was more vulnerable to drought than
 that of herbaceous plants at ambient temperature, but this difference
 diminished at Te. Perennial herbs exhibited a stronger amplifying effect
 of Te on plant biomass in response to drought than did annual herbs. Te
 exacerbated the responses of Agrowth and stomatal conductance to drought
 for evergreen broadleaf trees rather than for deciduous broadleaf and
 evergreen coniferous trees. A negative Te × drought interaction on plant
 biomass was observed on the species level rather than on the community
 level. Collectively, our findings provide a mechanistic understanding of
 the interactive effects of Te and drought on plant C metabolism, which
 would improve the prediction of climate change impacts.
DOI: 10.5281/zenodo.18402957
title: Shodmonova Xadicha Alisher qizi, & Worldly Knowledge Publishing Centre. (2026). Xojiyev Shohruh Saidjappar o'g'li, & Worldly Knowledge Publishing Centre. (2026). RAQAMLI TEXNOLOGIYALAR ASOSIDA MASHG'ULOT JARAYONINI REJALASHTIRISH [Data set]. В ILM FAN XABARNOMASI (Т. 11, Выпуск 02, сс. 2444–2452). Zenodo. https://doi.org/10.5281/zenodo.18402846 [Data set]. В International journal of scientific researchers (Т. 15, Выпуск 02, сс. 502–506). Zenodo. https://doi.org/10.5281/zenodo.18402881

description: Farmatsevtika sanoatida sifat standartlari bemor  xavfsizligi va dori vositalarining samaradorligini kafolatlash  uchun zarur bo'lgan qoidalar va talablar tizimi hisoblanadi. Ushbu standartlar global darajada bir xil sifat darajasini  ta'minlaydi va har bir mahsulotning ishlab chiqarishdan  bemorga yetguncha bo'lgan yo'lda barcha bosqichlarda  nazorat ostida bo'lishini kafolatlaydi.

Dori vositalarining har bir partiyasi  xavfsizlik sinovlaridan o'tadi va  bemorlar uchun xatarsiz ekanligiga  ishonch hosil qilinadi. Standartlar dori vositalarining  kafolatlangan terapevtik ta'sir  ko'rsatishini va bemorlarni  davolashda ijobiy natijalar berishini  ta'minlaydi. Xalqaro bozorlarga chiqish, eksport  qilish va global hamkorlik uchun sifat  standartlariga muvofiqlik majburiy  shartdir. Hozirgi vaqtda quyidagi halqaro sifat standartlari tafovutlanadi:

GMP ( Zarur ishlab chiqarish amaliyoti), GCP (Zarur klinik amaliyot), GLP(Zarur laboratoriya amaliyoti), GDP (Zarur tarqatish amaliyoti), GPvP( Zarur farmakovigilans amaliyoti).  Hozirgi sharoitda O`zbekiston Respublikasidagi barcha dorixona muassasalari GPP (Zarur dorixona amaliyoti) standarti talablariga to`la-to`kis javob berishlari lozim.
DOI: 10.5281/zenodo.18402958
title: Shodmonova Xadicha Alisher qizi, & Worldly Knowledge Publishing Centre. (2026). Xojiyev Shohruh Saidjappar o'g'li, & Worldly Knowledge Publishing Centre. (2026). RAQAMLI TEXNOLOGIYALAR ASOSIDA MASHG'ULOT JARAYONINI REJALASHTIRISH [Data set]. В ILM FAN XABARNOMASI (Т. 11, Выпуск 02, сс. 2444–2452). Zenodo. https://doi.org/10.5281/zenodo.18402846 [Data set]. В International journal of scientific researchers (Т. 15, Выпуск 02, сс. 502–506). Zenodo. https://doi.org/10.5281/zenodo.18402881

description: Farmatsevtika sanoatida sifat standartlari bemor  xavfsizligi va dori vositalarining samaradorligini kafolatlash  uchun zarur bo'lgan qoidalar va talablar tizimi hisoblanadi. Ushbu standartlar global darajada bir xil sifat darajasini  ta'minlaydi va har bir mahsulotning ishlab chiqarishdan  bemorga yetguncha bo'lgan yo'lda barcha bosqichlarda  nazorat ostida bo'lishini kafolatlaydi.

Dori vositalarining har bir partiyasi  xavfsizlik sinovlaridan o'tadi va  bemorlar uchun xatarsiz ekanligiga  ishonch hosil qilinadi. Standartlar dori vositalarining  kafolatlangan terapevtik ta'sir  ko'rsatishini va bemorlarni  davolashda ijobiy natijalar berishini  ta'minlaydi. Xalqaro bozorlarga chiqish, eksport  qilish va global hamkorlik uchun sifat  standartlariga muvofiqlik majburiy  shartdir. Hozirgi vaqtda quyidagi halqaro sifat standartlari tafovutlanadi:

GMP ( Zarur ishlab chiqarish amaliyoti), GCP (Zarur klinik amaliyot), GLP(Zarur laboratoriya amaliyoti), GDP (Zarur tarqatish amaliyoti), GPvP( Zarur farmakovigilans amaliyoti).  Hozirgi sharoitda O`zbekiston Respublikasidagi barcha dorixona muassasalari GPP (Zarur dorixona amaliyoti) standarti talablariga to`la-to`kis javob berishlari lozim.
DOI: 10.5061/dryad.79cnp5j0f
title: Supporting information for: The correct name for an Aquilegia (Ranunculaceae) hybrid of the parentage Aquilegia flavescens × A. formosa

description: Aquilegia x miniana (J.F.Macbr. &
 Payson) Cronk, hybr. & stat. nov. is the correct name for the
 hybrid Aquilegia flavescens S.Watson x A.
 formosa Fisch. ex DC. var. formosa. In 1916, Payson and
 Macbride, while exploring the mountains of Idaho, found populations of
 Aquilegia that were pink in flower colour and appeared
 intermediate between the yellow-flowered A.
 flavescens and red-flowered A. formosa. They named these
 plants A.
 flavescens var. miniana J.F.Macbr. &
 Payson. There has been uncertainty over whether their type collections (in
 GH, RM, MO, US, E, CM, CAS, NY) do indeed represent hybrids or
 pink-flowered morphs of A. flavescens. Using a Wells diagram, the
 holotype (in the Gray Herbarium of Harvard University) is shown to be
 intermediate, allowing its identification as a clear hybrid. However, some
 of the isotype material is indistinguishable from A. flavescens.
 The holotype matches material from British Columbia that has been
 determined as being of hybrid origin using molecular and morphological
 data. A.
 flavescens var. miniana J.F.Macbr. &
 Payson is, therefore, an available name for the hybrid, which is here
 raised to the status of hybrid binomial.
description: A full description of the collection of the dataset is given in
 previous publications. The morphometric data is taken from herbarium
 specimens and is previously generated and described by Groh et al. (2019)
 and Groh and Cronk (2020) References
 Ref: Groh JS, Percy DM, Björk CR, Cronk QC (2019) On the origin
 of orphan hybrids between <em>Aquilegia</em>
 <em>formosa</em> and <em>Aquilegia</em>
 <em>flavescens</em>. AoB Plants 11(1): ply071. 
 Groh JS, Cronk QCB (2020) Mosaic hybrid zone structure in two
 species of columbine (<em>Aquilegia</em>). Botany 98 (8):
 459–467 doi: 10.1139/cjb-2020-001 ---
 Analysis: the LDA analysis was conducted in PAST
 The Wells diagram was made using Excel (Microsoft Excel for Mac,
 version 16.63.1)
DOI: 10.5061/dryad.w6m905qtj
title: Triple-dip La Niña contributes to Pakistan flooding and southern China drought in summer 2022

description: In the summer of 2022, a long-lasting La Niña entered its third year. In
 Asia, southern China was in the grip of a historic drought while heavy
 rainfall ravaged Pakistan. Using a climate model forced by observed sea
 surface temperatures (SST) over the equatorial Pacific, we show that the
 back-to-back La Niña events from 2020 to 2022 are a key contributor to the
 global SST pattern in 2022 including the negative phase of Pacific decadal
 oscillation and exceptionally strong negative Indian Ocean dipole. The
 model reproduces the observed precipitation pattern over South and East
 Asia, including enhanced rainfall over Pakistan–northwest India and
 reduced rainfall over southern China. Additional model simulations
 indicate that the negative Indian Ocean dipole combined with La Niña can
 decrease southern China rainfall by causing anomalous subsidence and
 anticyclonic flows. These results highlight the dominant role of
 long-lasting La Niña in modulating rainfall over heavily populated monsoon
 Asia.