cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22638639.v1
title: Resveratrol inhibits nicotine-induced conditioned place preference in mice

description: Abstract Nicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4’-tetrahydroxystilbene) is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine’s reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property.
DOI: 10.6084/m9.figshare.21907768
title: Behavioral characterization of ayahuasca treatment on Wistar rats in the open field test

description: Abstract Ayahuasca (AYA) is a psychedelic beverage with therapeutic potential for many mood and anxiety disorders. Although there are some preclinical studies, no published reports have tested the behavioral effects of AYA gavage in animal models. This investigation aimed to characterize the behavior of Wistar rats after acute ingestion of AYA for 40 min in the open field test (OFT). The sample consisted of three experimental groups treated with different dosages of AYA (125, 250, or 500 mg kg-1) and a control group. Each group consisted of 10 participants. After gavage, the number of crossings of the OFT grid lines, latency to enter the central area of the device, grooming frequency, and time spent in the central perimeter of the device were immediately evaluated. Analyses were based on one-way ANOVA and a linear-regression mixture model for longitudinal data. AYA intake did not interfere with habituation. The 500 mg kg-1 group showed a decrease in the time spent in the center of the device and in the number of crossings compared to the control group in the last 10 min. These results suggest that gavage with AYA did not interfere with the results, and the behavioral effects were perceived only between 30 and 40 min after gavage. Taken together, the results indicate that three aspects should be considered in OFT studies of AYA acute effects: the moment when the observation starts, the observation period, and the AYA dosage.
DOI: 10.6084/m9.figshare.22638639
title: Resveratrol inhibits nicotine-induced conditioned place preference in mice

description: Abstract Nicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4’-tetrahydroxystilbene) is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine’s reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property.
DOI: 10.6084/m9.figshare.21907768.v1
title: Behavioral characterization of ayahuasca treatment on Wistar rats in the open field test

description: Abstract Ayahuasca (AYA) is a psychedelic beverage with therapeutic potential for many mood and anxiety disorders. Although there are some preclinical studies, no published reports have tested the behavioral effects of AYA gavage in animal models. This investigation aimed to characterize the behavior of Wistar rats after acute ingestion of AYA for 40 min in the open field test (OFT). The sample consisted of three experimental groups treated with different dosages of AYA (125, 250, or 500 mg kg-1) and a control group. Each group consisted of 10 participants. After gavage, the number of crossings of the OFT grid lines, latency to enter the central area of the device, grooming frequency, and time spent in the central perimeter of the device were immediately evaluated. Analyses were based on one-way ANOVA and a linear-regression mixture model for longitudinal data. AYA intake did not interfere with habituation. The 500 mg kg-1 group showed a decrease in the time spent in the center of the device and in the number of crossings compared to the control group in the last 10 min. These results suggest that gavage with AYA did not interfere with the results, and the behavioral effects were perceived only between 30 and 40 min after gavage. Taken together, the results indicate that three aspects should be considered in OFT studies of AYA acute effects: the moment when the observation starts, the observation period, and the AYA dosage.
DOI: 10.6084/m9.figshare.22638644.v1
title: Epistemologies of Presence, theorexperience: women’s production on Cultural Performances

description: ABSTRACT This paper reviews women’s theoretical production in the field of Cultural Performances, evincing that these scholars themselves have still not sufficiently referred to other women theorists’ epistemologies. In this context, the work demonstrates how important it is for women scholars to make theory from other epistemological standpoints which include both their corporeality as researchers and the corporeality of knowledge in their studies. Being theoretical writing a form of performative writing, as a conclusion the paper considers this writing as founded on the shift of hegemonic writing codes in which academic research and practice, theory and everyday life experience work together.
DOI: 10.6084/m9.figshare.22638644
title: Epistemologies of Presence, theorexperience: women’s production on Cultural Performances

description: ABSTRACT This paper reviews women’s theoretical production in the field of Cultural Performances, evincing that these scholars themselves have still not sufficiently referred to other women theorists’ epistemologies. In this context, the work demonstrates how important it is for women scholars to make theory from other epistemological standpoints which include both their corporeality as researchers and the corporeality of knowledge in their studies. Being theoretical writing a form of performative writing, as a conclusion the paper considers this writing as founded on the shift of hegemonic writing codes in which academic research and practice, theory and everyday life experience work together.
DOI: 10.6084/m9.figshare.20217510.v1
title: A new combination of naringin and trimetazidine protect kidney Mitochondria dysfunction induced by renal Ischemia / Reperfusion injury in rat

description: Abstract Ischemia/reperfusion (IR) injury leads to overproduction of Reactive Oxygen Species (ROS), and disrupts membrane potential that contributes to cell death. The aim of this study was to determine if naringin (NAR), trimetazidine (TMZ) or their combination, protect the kidney mitochondrial from IR injury. Forty rats were randomly allocated into five groups, harboring eight rats each: Sham, IR, NAR (100 mg/kg), TMZ (5 mg/kg) and NAR plus TMZ. Ischemia was induced by obstructing both renal pedicles for 45 min, followed by reperfusion for 4 hours. The mitochondria were isolated to examine the ROS, Malondialdehyde (MDA), Glutathione (GSH), mitochondrial membrane potential (MMP) and mitochondrial viability (MTT). Our findings indicated that IR injury resulted in excessive ROS production, increased MDA levels and decreased GSH, MMP and MMT levels. However, NAR, TMZ or their combination reversed these changes. Interestingly, a higher protection was noted with the combination of both, compared to each drug alone. We speculate that this combination demonstrates a promising process for controlling renal failure, especially with the poor clinical outcome, acquired with NAR alone. This study revealed that pretreatment their combination serves as a promising compound against oxidative stress, leading to suppression of mitochondrial stress pathway and elevation of GSH level.
DOI: 10.5281/zenodo.7790871
title: Sharing data and code supporting the article entitled "Thermodynamically enhanced precipitation extremes due to counterbalancing influences of anthropogenic greenhouse gases and aerosols"

description: The public data repository contains the data and plotting code supporting the article entitled "Thermodynamically enhanced precipitation extremes due to counterbalancing influences of anthropogenic greenhouse gases and aerosols". The dataset includes annual maximum one-day precipitation (Rx1day), its proxy computed by a physical scaling diagnostic (scaling), and the decomposed components of the scaling (i.e., thermodynamic response, dynamic response, and their interaction). Several reanalyses (including ERA5 and JRA55) and CMIP6 simulations under several scenarios (including ALL, GHG, AER, and piControl) are applied to compute the historical Rx1day, scaling, and the associated components following a GitHub Python repository (https://github.com/oliverangelil/precip_extremes_scaling). Note that the decomposed components are calculated as anomalies. The data results of the extreme precipitation decomposition in the NetCDF format are available in zip files “<em><strong>ERA5</strong></em>”, "<em><strong>JRA55</strong></em>", "<em><strong>ALL</strong></em>", "<em><strong>GHG</strong></em>", "<em><strong>AER</strong></em>", "<em><strong>NAT</strong></em>", and "<em><strong>piControl</strong></em>". Code for visualizations is available in the "<em><strong>Jupyter Notebooks</strong></em>" zip file.
DOI: 10.5281/zenodo.7790872
title: Sharing data and code supporting the article entitled "Thermodynamically enhanced precipitation extremes due to counterbalancing influences of anthropogenic greenhouse gases and aerosols"

description: The public data repository contains the data and plotting code supporting the article entitled "Thermodynamically enhanced precipitation extremes due to counterbalancing influences of anthropogenic greenhouse gases and aerosols". The dataset includes annual maximum one-day precipitation (Rx1day), its proxy computed by a physical scaling diagnostic (scaling), and the decomposed components of the scaling (i.e., thermodynamic response, dynamic response, and their interaction). Several reanalyses (including ERA5 and JRA55) and CMIP6 simulations under several scenarios (including ALL, GHG, AER, and piControl) are applied to compute the historical Rx1day, scaling, and the associated components following a GitHub Python repository (https://github.com/oliverangelil/precip_extremes_scaling). Note that the decomposed components are calculated as anomalies. The data results of the extreme precipitation decomposition in the NetCDF format are available in zip files “<em><strong>ERA5</strong></em>”, "<em><strong>JRA55</strong></em>", "<em><strong>ALL</strong></em>", "<em><strong>GHG</strong></em>", "<em><strong>AER</strong></em>", "<em><strong>NAT</strong></em>", and "<em><strong>piControl</strong></em>". Code for visualizations is available in the "<em><strong>Jupyter Notebooks</strong></em>" zip file.
DOI: 10.6084/m9.figshare.20217510
title: A new combination of naringin and trimetazidine protect kidney Mitochondria dysfunction induced by renal Ischemia / Reperfusion injury in rat

description: Abstract Ischemia/reperfusion (IR) injury leads to overproduction of Reactive Oxygen Species (ROS), and disrupts membrane potential that contributes to cell death. The aim of this study was to determine if naringin (NAR), trimetazidine (TMZ) or their combination, protect the kidney mitochondrial from IR injury. Forty rats were randomly allocated into five groups, harboring eight rats each: Sham, IR, NAR (100 mg/kg), TMZ (5 mg/kg) and NAR plus TMZ. Ischemia was induced by obstructing both renal pedicles for 45 min, followed by reperfusion for 4 hours. The mitochondria were isolated to examine the ROS, Malondialdehyde (MDA), Glutathione (GSH), mitochondrial membrane potential (MMP) and mitochondrial viability (MTT). Our findings indicated that IR injury resulted in excessive ROS production, increased MDA levels and decreased GSH, MMP and MMT levels. However, NAR, TMZ or their combination reversed these changes. Interestingly, a higher protection was noted with the combination of both, compared to each drug alone. We speculate that this combination demonstrates a promising process for controlling renal failure, especially with the poor clinical outcome, acquired with NAR alone. This study revealed that pretreatment their combination serves as a promising compound against oxidative stress, leading to suppression of mitochondrial stress pathway and elevation of GSH level.
DOI: 10.6084/m9.figshare.22638647
title: Health changes during Covid-19: a nationwide study with dental students

description: ABSTRACT OBJECTIVE To assess the changes in stress levels, social behavior, dietary and parafunctional habits, oral hygiene, among other conditions perceived by dental students in Brazil during the Covid-19 pandemic and evaluated the correlations between stress level and other variables. METHODS An online questionnaire was developed and validated. Undergraduates enrolled in private and public dental schools were recruited by convenience sampling. Data were collected on the perceived changes regarding stress levels, financial and social characteristics, dietary habits, oral hygiene, health conditions, and parafunctional habits. Quantitative variables were expressed as absolute and relative frequencies. Wilcoxon test evaluated comparisons between perceived changes, and correlations between changes in stress levels and other variables were analyzed by Spearman correlation (α = 0.05). RESULTS A total of 638 dental students, mean age of 22.95 ± 4.10 years, participated in the study. During the pandemic, the reported stress levels increased while household income decreased (p &lt; 0.05). Late dinners and mindless eating increased in frequency, whereas oral hygiene decreased (p &lt; 0.05). Most of the health conditions and parafunctional habits assessed changed (p &lt; 0.05). Perceived stress levels showed poor negative correlations with household income (rS = −0.14), poor positive correlations with the pressure to contribute financially in the household (rS = 0.19), and poor positive correlations with food choice frequency (rS = 0.15) (p &lt; 0.05). CONCLUSIONS Dental students reported perceived changes in stress levels, dietary habits, oral hygiene, health conditions, parafunctional habits, and social behavior. Moreover, the results showed poor correlations, as students with higher stress levels tended to have the lowest household income, feel pressured to contribute financially in the household, and present a high meal intake frequency.
DOI: 10.6084/m9.figshare.22638647.v1
title: Health changes during Covid-19: a nationwide study with dental students

description: ABSTRACT OBJECTIVE To assess the changes in stress levels, social behavior, dietary and parafunctional habits, oral hygiene, among other conditions perceived by dental students in Brazil during the Covid-19 pandemic and evaluated the correlations between stress level and other variables. METHODS An online questionnaire was developed and validated. Undergraduates enrolled in private and public dental schools were recruited by convenience sampling. Data were collected on the perceived changes regarding stress levels, financial and social characteristics, dietary habits, oral hygiene, health conditions, and parafunctional habits. Quantitative variables were expressed as absolute and relative frequencies. Wilcoxon test evaluated comparisons between perceived changes, and correlations between changes in stress levels and other variables were analyzed by Spearman correlation (α = 0.05). RESULTS A total of 638 dental students, mean age of 22.95 ± 4.10 years, participated in the study. During the pandemic, the reported stress levels increased while household income decreased (p &lt; 0.05). Late dinners and mindless eating increased in frequency, whereas oral hygiene decreased (p &lt; 0.05). Most of the health conditions and parafunctional habits assessed changed (p &lt; 0.05). Perceived stress levels showed poor negative correlations with household income (rS = −0.14), poor positive correlations with the pressure to contribute financially in the household (rS = 0.19), and poor positive correlations with food choice frequency (rS = 0.15) (p &lt; 0.05). CONCLUSIONS Dental students reported perceived changes in stress levels, dietary habits, oral hygiene, health conditions, parafunctional habits, and social behavior. Moreover, the results showed poor correlations, as students with higher stress levels tended to have the lowest household income, feel pressured to contribute financially in the household, and present a high meal intake frequency.
DOI: 10.6084/m9.figshare.22638648.v1
title: Xiao Lu: asserting her voice through artistic practice

description: ABSTRACT At the opening of the iconic exhibition China/Avant-Garde (1989, Beijing), the artist Xiao Lu fired two shots at her installation Dialogue and handed the gun to the artist Tang Song, who would later become her boyfriend. From that moment on, the artworld attributed the piece to Tang Song and Xiao Lu. Two decades after the event, Xiao Lu disputed the unique authorship of the artwork in a fictional memoir, Dialogue (2010). In this text, she presented a historiography of her art, reflecting on the performance and challenging Tang Song’s appropriation of the work. This article explores Xiao Lu’s re-writing of the official history of art and its patriarchal foundations through a feminist lens. It engages with complementary, contradictory, and contrasting readings of Xiao Lu's art and offers a new approach that addresses both the therapeutic and political dimensions of the artist's autobiographical account.
DOI: 10.6084/m9.figshare.22638648
title: Xiao Lu: asserting her voice through artistic practice

description: ABSTRACT At the opening of the iconic exhibition China/Avant-Garde (1989, Beijing), the artist Xiao Lu fired two shots at her installation Dialogue and handed the gun to the artist Tang Song, who would later become her boyfriend. From that moment on, the artworld attributed the piece to Tang Song and Xiao Lu. Two decades after the event, Xiao Lu disputed the unique authorship of the artwork in a fictional memoir, Dialogue (2010). In this text, she presented a historiography of her art, reflecting on the performance and challenging Tang Song’s appropriation of the work. This article explores Xiao Lu’s re-writing of the official history of art and its patriarchal foundations through a feminist lens. It engages with complementary, contradictory, and contrasting readings of Xiao Lu's art and offers a new approach that addresses both the therapeutic and political dimensions of the artist's autobiographical account.
DOI: 10.6084/m9.figshare.22638650
title: Hydrologic and hydraulic modeling to assess the efficiency of structural flood control measures: case study of Audi-União District in the city of Curitiba, Brazil

description: Abstract The objective of this study is to assess the efficiency of flood control measures implemented in the Audi-União District, located on the Iguaçu River floodplain in the city of Curitiba, Brazil, by the application of hydrological-hydraulic modeling using HEC-HMS and HEC-RAS software packages. The scenarios of the years of 2014, 2024 and 2034 with return periods of 10, 25, 50 and 100 years were analyzed. It was observed that the set of hydraulic structures located upstream of Audi-União District can reduce the peak flow at the beginning of the Iguaçu River by 31.4% and the flood area by 35.1%, considering the period of return of 100 years and the land use of 2014. Regarding the measures implemented directly by the Audi-União District, it was observed that the built levee can control floods in the area, except for a small area that is not protected by the levee, in both 2014 and future scenarios. The creation of the Iguaçu Environmental Protection Area and the relocation of families, which were non-structural measures implemented in the region, also proved to be efficient, considering that these areas would suffer from flooding even for rainfall events with a period of return of 10 years.
DOI: 10.6084/m9.figshare.22638653
title: How the user of the basic health unit views medical care by students

description: Abstract: Introduction: The importance of the SUS and its triad of universality, equity and integrity is essential to preserve the right to health, which, associated with a structured and effective practice of medicine, ensures improvements to community health. However, basic factors of physician-patient relations make it difficult for the effective practice of health care in the community, passing through all levels of health care, such as the Primary Health Care (PHC), at basic health units (BHU), which setting plays a key role in community health. These units also provide academic learning opportunities in medicine, promoting critical development with regard to humanisation in all sociocultural areas. Active user participation in this service, expressing views about the practice offered is crucial to understanding performance in various aspects of PHC, with repercussions in the users’ quality of life. Therefore, research is needed to understand the quality of service in the opinion of the users. Objective: The purpose of this research consists of understanding users’ perceptions as regards the care provided by medical students in PHC. Method: A qualitative study, with quantitative parts, was conducted in semi-structured and face-to-face interviews with users who received care from the students. The data was collected by means of content analysis categorisation. Result: Two categories were obtained, humanisation in user care and medical education integrated to the PHC service, in which the users report a humanised and integral practice as a result of the interaction between academics and the circumstances of the community. Conclusion: In the local circumstances, the users highlighted the present humanisation in the care provided, which reinforced the importance of the link between the student, user and the community, as well as reflecting the study of medicine that stimulates early contact with the PHC, as a means of skills and humanistic training.