cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8294723
title: Nonclinical toxicology studies with sodium taurodeoxycholate: acute and subacute toxicity in dogs

description: Sodium taurodeoxycholate (TDCA) has been investigated for various inflammatory disorders such as sepsis. We recently evaluated nonclinical safety profile of TDCA using rats infused intravenously. As a series of preclinical safety investigations, we further conducted toxicity studies with TDCA delivered to dogs <i>via</i> intravenous administration under Good Laboratory Practice regulation in this study. In dose range-finding study (dose escalation study), dogs given with TDCA at a dose of 150 mg/kg showed marked changes in clinical signs, hematology, and serum biochemistry. And biochemical markers of liver damage and local skin lesions were observed following intravenous infusion of 100 mg/kg TDCA, suggesting that 100 mg/kg was chosen as the highest dose of TDCA for 4-week repeated-dose toxicity study using dogs. Despite no treatment-related significant changes in body weight, food consumption, ophthalmoscopy, and urinalysis, skin lesions were observed at the injection site of animals administered with higher than 50 mg/kg of TDCA along with biochemical and histopathological changes associated with liver injury. However, most of off-target effects were found to be reversible since these were recovered after stopping TDCA infusion. These findings indicate that the no-observed-adverse-effect-level (NOAEL) for TDCA in dogs was considered to be 5 mg/kg/d. Taken together, our results provide important toxicological profiles regarding the safe dose of TDCA for drug development or clinical application.
DOI: 10.6084/m9.figshare.8294723.v1
title: Nonclinical toxicology studies with sodium taurodeoxycholate: acute and subacute toxicity in dogs

description: Sodium taurodeoxycholate (TDCA) has been investigated for various inflammatory disorders such as sepsis. We recently evaluated nonclinical safety profile of TDCA using rats infused intravenously. As a series of preclinical safety investigations, we further conducted toxicity studies with TDCA delivered to dogs <i>via</i> intravenous administration under Good Laboratory Practice regulation in this study. In dose range-finding study (dose escalation study), dogs given with TDCA at a dose of 150 mg/kg showed marked changes in clinical signs, hematology, and serum biochemistry. And biochemical markers of liver damage and local skin lesions were observed following intravenous infusion of 100 mg/kg TDCA, suggesting that 100 mg/kg was chosen as the highest dose of TDCA for 4-week repeated-dose toxicity study using dogs. Despite no treatment-related significant changes in body weight, food consumption, ophthalmoscopy, and urinalysis, skin lesions were observed at the injection site of animals administered with higher than 50 mg/kg of TDCA along with biochemical and histopathological changes associated with liver injury. However, most of off-target effects were found to be reversible since these were recovered after stopping TDCA infusion. These findings indicate that the no-observed-adverse-effect-level (NOAEL) for TDCA in dogs was considered to be 5 mg/kg/d. Taken together, our results provide important toxicological profiles regarding the safe dose of TDCA for drug development or clinical application.
DOI: 10.6084/m9.figshare.15110211.v1
title: Additional file 7 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 7. Table S6. The sequence read archive published data used in this study.
DOI: 10.6084/m9.figshare.15110196
title: Additional file 3 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 3. Table S2. Different types of ACRs in diploid and autotetraploid rice.
DOI: 10.6084/m9.figshare.15110193
title: Additional file 2 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 2. Table S1. Sequenced data alignment summary.
DOI: 10.6084/m9.figshare.15110193.v1
title: Additional file 2 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 2. Table S1. Sequenced data alignment summary.
DOI: 10.6084/m9.figshare.15110199.v1
title: Additional file 4 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 4. Table S3. The detailed information of differential expression genes in 2x and 4x rice.
DOI: 10.6084/m9.figshare.15110199
title: Additional file 4 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 4. Table S3. The detailed information of differential expression genes in 2x and 4x rice.
DOI: 10.6084/m9.figshare.15110211
title: Additional file 7 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 7. Table S6. The sequence read archive published data used in this study.
DOI: 10.6084/m9.figshare.15110208
title: Additional file 6 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 6. Table S5. List of KEGG and Gowinda terms of gACR-specific associated genes and up-regulated genes in diploid and autotetraploid rice.
DOI: 10.6084/m9.figshare.20353353
title: Jet2 Features

description: This folder includes the features of human and yeast proteins calculated by Jet2.
DOI: 10.6084/m9.figshare.21926087
title: Functional Outlier Detection for Density-Valued Data with Application to Robustify Distribution-to-Distribution Regression

description: Distributional data analysis, concerned with the statistical analysis of data objects consisting of random probability distributions in the framework of functional data analysis (FDA), has received considerable interest in recent years and is increasingly applied in various fields including engineering. Outlier detection and robustness are of great practical interest; however, these aspects remain unexplored for distributional data. To this end, this study focuses on density-valued outlier detection and its application in robust distributional regression. Specifically, we propose a transformation-based approach for single-dataset outlying density detection with an emphasis on converting the less detectable shape outliers to easily detectable magnitude outliers. We also propose a distributional regression-based approach for detecting the abnormal associations of the density-valued two-tuples associated with two datasets. Then, the proposed outlier detection methods are applied to robustify a distribution-to-distribution regression method used in engineering, and we develop a robust estimator for the regression operator by downweighting the detected outliers. The proposed methods are validated and evaluated via extensive simulation studies. The relevant results reveal the superiority of our method over other competitors in distributional outlier detection. A case study in structural health monitoring demonstrates the great potential of our proposal in engineering applications. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.21926087.v1
title: Functional Outlier Detection for Density-Valued Data with Application to Robustify Distribution-to-Distribution Regression

description: Distributional data analysis, concerned with the statistical analysis of data objects consisting of random probability distributions in the framework of functional data analysis (FDA), has received considerable interest in recent years and is increasingly applied in various fields including engineering. Outlier detection and robustness are of great practical interest; however, these aspects remain unexplored for distributional data. To this end, this study focuses on density-valued outlier detection and its application in robust distributional regression. Specifically, we propose a transformation-based approach for single-dataset outlying density detection with an emphasis on converting the less detectable shape outliers to easily detectable magnitude outliers. We also propose a distributional regression-based approach for detecting the abnormal associations of the density-valued two-tuples associated with two datasets. Then, the proposed outlier detection methods are applied to robustify a distribution-to-distribution regression method used in engineering, and we develop a robust estimator for the regression operator by downweighting the detected outliers. The proposed methods are validated and evaluated via extensive simulation studies. The relevant results reveal the superiority of our method over other competitors in distributional outlier detection. A case study in structural health monitoring demonstrates the great potential of our proposal in engineering applications. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.15110214
title: Additional file 8 of A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling

description: Additional file 8. Table S7. List of differential accumulated metabolites in diploid and autotetraploid rice.
DOI: 10.1594/pangaea.783533
title: Porewater geochemistry of sediment core SO206-0029-1
DOI: 10.15468/dl.fcqzcv
title: Occurrence Download

description: A dataset containing 133 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Meriones tamariscinus (Pallas, 1773)"
 ]
}

 The dataset includes 133 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000231-150306150734599/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.784024
title: Geochemistry of sediment core M66/3a_135
DOI: 10.1594/pangaea.784027
title: Geochemistry of sediment core M66/3a_144
DOI: 10.1594/pangaea.783534
title: Porewater geochemistry of sediment core SO206-0031-1
DOI: 10.1594/pangaea.784028
title: Geochemistry of sediment core M66/3a_146
DOI: 10.1594/pangaea.784033
title: Geochemistry of sediment core M66/3a_154
DOI: 10.15468/dl.bdv6gz
title: Occurrence Download

description: A dataset containing 47935 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Census of plant species in Benin as part of several research projects"
 ]
}

 The dataset includes 47935 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0142838-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.783535
title: Porewater geochemistry of sediment core SO206-0032-1
DOI: 10.1594/pangaea.783536
title: Porewater geochemistry of sediment core SO206-0038-1
DOI: 10.15468/dl.8uynec
title: Occurrence Download

description: A dataset containing 89 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Schinopsis lorentzii (Griseb.) Engl."
 ]
}

 The dataset includes 89 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000231-150422101436696/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.783537
title: Porewater geochemistry of sediment core SO206-0039-1
DOI: 10.1594/pangaea.783538
title: Porewater geochemistry of sediment core SO206-0040-1
DOI: 10.1594/pangaea.784034
title: Geochemistry of sediment core M66/3a_159
DOI: 10.1594/pangaea.783539
title: Porewater geochemistry of sediment core SO206-0044-1
DOI: 10.15468/dl.hzqv36
title: Occurrence Download

description: A dataset containing 43 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Acrocomia hassleri (Barb.Rodr.) W.J.Hahn",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 43 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000791-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.783540
title: Porewater geochemistry of sediment core SO206-0046-1
DOI: 10.15468/dl.r2qnt5
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Peperomia granulata Trel. & Yunck."
 ]
}

 The dataset includes 13 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0182767-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.783541
title: Porewater geochemistry of sediment core SO206-0050-1
DOI: 10.1594/pangaea.784039
title: Geochemistry of sediment core M66/3a_168
DOI: 10.15468/dl.0jwvtr
title: Occurrence Download

description: A dataset containing 50 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Protea cryophila Bolus",
 "Country is South Africa",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 50 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000231-150512124619364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.783542
title: Porewater geochemistry of sediment core SO206-0051-1
DOI: 10.1594/pangaea.784041
title: Geochemistry of sediment core M66/3a_175
DOI: 10.1594/pangaea.783543
title: Porewater geochemistry of sediment core SO206-0054-1
DOI: 10.1594/pangaea.784045
title: Geochemistry of sediment core M66/3a_190
DOI: 10.15468/dl.lilfbe
title: Occurrence Download

description: A dataset containing 588 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Trachycarpus fortunei (Hook.) H.Wendl.",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 588 records from 72 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000791-180730143533302/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.784047
title: Geochemistry of sediment core M66/3a_197
DOI: 10.1594/pangaea.784052
title: Geochemistry of sediment core M66/3a_213
DOI: 10.1594/pangaea.785909
title: Chemistry measurements of pore water from IODP Hole 333-C0012E

description: Geocode = [m CSF-A] Top Core depth (below sea floor)
DOI: 10.15468/dl.l8qs2y
title: Occurrence Download

description: A dataset containing 255 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Diploglossus Wiegmann, 1834",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 255 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000231-150721130643939/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.1594/pangaea.783587
title: Chemistry measurements of pore water from IODP Hole 333-C0018A

description: Geocode = [m CSF-A] Top Core depth (below sea floor)
DOI: 10.1594/pangaea.785378
title: (Table 2) Concentration of heavy metals and organic carbon, and 210Pb activity of sediments near Büsum, eastern Wadden Sea

description: A 3.38 m long sediment core raised from the tidal flat sediments of the 'Blauortsand' in the Wadden Sea northwest of Büsum (Schleswig-Holstein, Germany) was analysed in order to investigate long term changes in sediment pollution with Pb, Cu, Zn and Cd. Comparison with the topographic maps since 1952 and 210Pb activity allowed a general dating of the sediment succession in the core. The heavy metal concentrations including 210Pb of the &lt; 20 µm grain-size fraction in thick sediment slices below 1.30 m indicated background niveaus. Their values increased and reached modern levels in the upper sediment layers of the core above 1 m. The increments for Pb, Cu, Zn was 1 to 3 fold and Cd up to 11 fold since the second half of the 19th century. More investigations are needed to quantify the geographical extent and history of the contaminations shown in this pilot study.
description: Sediment fraction &lt;20 µm was analyzed.
description: Supplement to: Höck, Magdalena; Runte, Karl-Heinz (1996): Schwermetallkonzentrationen in einem Schichtprofil aus den Watten nordwestlich von Büsum. Meyniana, 48, 35-48
DOI: 10.1594/pangaea.784933
title: Geochemistry of sediment core M54/3A_116
DOI: 10.1594/pangaea.784934
title: Geochemistry of sediment core M54/3A_119-2 F
DOI: 10.1594/pangaea.784935
title: Geochemistry of sediment core M54/3A_119-2 G
DOI: 10.1594/pangaea.784936
title: Geochemistry of sediment core M54/3A_123-1D
DOI: 10.1594/pangaea.784937
title: Geochemistry of sediment core M54/3A_123-1E
DOI: 10.1594/pangaea.784938
title: Geochemistry of sediment core M54/3A_123-2
DOI: 10.1594/pangaea.784940
title: Geochemistry of sediment core M54/3A_129-2
DOI: 10.1594/pangaea.784942
title: Geochemistry of sediment core M54/3A_133
DOI: 10.1594/pangaea.784944
title: Geochemistry of sediment core M54/3A_137-1
DOI: 10.1594/pangaea.784945
title: Geochemistry of sediment core M54/3A_138
DOI: 10.1594/pangaea.784946
title: Geochemistry of sediment core M54/3A_143
DOI: 10.1594/pangaea.784947
title: Geochemistry of sediment core M54/3A_148
DOI: 10.1594/pangaea.784948
title: Geochemistry of sediment core M54/3A_149BC1
DOI: 10.1594/pangaea.784949
title: Geochemistry of sediment core M54/3A_149BC2
DOI: 10.1594/pangaea.784950
title: Geochemistry of sediment core M54/3A_153
DOI: 10.1594/pangaea.784951
title: Geochemistry of sediment core M54/3A_155
DOI: 10.1594/pangaea.784952
title: Geochemistry of sediment core M54/3A_159
DOI: 10.1594/pangaea.784953
title: Geochemistry of sediment core M54/3A_163-1
DOI: 10.1594/pangaea.784954
title: Geochemistry of sediment core M54/3A_163-3
DOI: 10.1594/pangaea.784955
title: Geochemistry of sediment core M54/3A_164
DOI: 10.1594/pangaea.784957
title: Geochemistry of sediment core M54/3A_171
DOI: 10.1594/pangaea.784958
title: Geochemistry of sediment core M54/3A_173-1
DOI: 10.1594/pangaea.784959
title: Geochemistry of sediment core M54/3A_173-2
DOI: 10.1594/pangaea.784961
title: Geochemistry of sediment core M54/3A_174BC1
DOI: 10.1594/pangaea.784963
title: Geochemistry of sediment core M54/3A_175
DOI: 10.1594/pangaea.784964
title: Geochemistry of sediment core M54/3A_176-2
DOI: 10.1594/pangaea.784965
title: Geochemistry of sediment core M54/3A_179
DOI: 10.1594/pangaea.784966
title: Geochemistry of sediment core M54/3A_185BC2
DOI: 10.15468/dl.fenvjp
title: Occurrence Download

description: A dataset containing 2260307000 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Occurrence evidence, Human Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2260307000 records from 32080 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000766-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-104393
title: Cowgirl on horseback, Los Angeles County, Calif., 1941

description: 24 photographs of a cowgirl and a cowboy on horseback, Los Angeles County, California, 1941 July 21.
DOI: 10.15468/dl.yysb8g
title: Occurrence Download

description: A dataset containing 865 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Africa",
 "TaxonKey is Stomoxys calcitrans (Linnaeus, 1758)"
 ]
}

 The dataset includes 865 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006571-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-57611
title: Marion Shilling at Bel Air, Los Angeles, CA, 1932

description: 3 photographs of Marion Shilling, 3 men, and telescope, Los Angeles, CA, 1932. "Subject: Marion Shilling at Bel Air; Agency: Burtnett; Client: Cha[rle]s Hopper; Original print order: 1 ea[ch]; Size: 8x10; Finish: gl[ossy]; Year: 1932; Job: 11-4-22" -- on envelope front. "Operator's report: Dick; Original photographs: 3; Size: 8x10; Amount: 5.00" -- on envelope back.
DOI: 10.25549/whit-c170-54279
title: Property at 529 Laveta Terrace, Los Angeles, CA, 1935

description: 3 photographs of property at 529 Laveta Terrace, Los Angeles, CA, 1935. "Subject: Property at 529 Laveta Terrace; Client: Davis & Thorne, Mr. Pitney; Original Print Order; Size: 8x10; Finish: gl[ossy]; Job: 4-10-76; Year: 1935" -- on envelope front. "Operator's Report Name: Dean; Original Photographs--Size: 3 - 8x10 ext[erior]; Amount: 6.00" -- on envelope back.
DOI: 10.25549/whit-c170-54311
title: Estelle Etterre and Blair McKenzie, Southern California, 1932

description: 12 photographs of Estelle Etterre and Blair McKenzie posing with glass of juice, Southern California, 1932. "Subject: Estelle Etterre & Blair McKenzie; Client: Gordon Provonsha; Size: Proof; Re-Order: 1- #1, 2, 3; Size: 11x14; Finish: gl[ossy]; Job: 11-1-3; Year: 1932" -- on envelope front. "Operator's Report Name: Dick; Original Photographs-Size: -3 models only @5.00, 1 model only @5.00; Amount: 15.00, 2.50; Extra Charges: Provonsha" -- on envelope back.
DOI: 10.15468/dl.arzra3
title: Occurrence Download

description: A dataset containing 59928 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "DatasetKey is BIGOOD"
 ]
}

 The dataset includes 59928 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078537-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-57654
title: Intersection of Rosemont Avenue & West Temple Street, Los Angeles, CA, 1932

description: 4 photographs of intersection of Rosemont Avenue & West Temple Street, Los Angeles, CA, 1932. "Subject: Intersection of Rosemont & Temple; Client: Univ[ersal] Auto Ins[urance] Co., Hoffman; Classifications: L-Street scene-day; Original Print Order: 1 ea[ch]; Size: 8x10; Finish: gl[ossy]; Year: 1932; Job: 11-28-145" -- on envelope front. "Operator's Report Name: Henry; 4 Original Photographs-Size: 8x10; Amount: 6.00" -- on envelope back.
DOI: 10.15468/dl.5jwdx2
title: Occurrence Download

description: A dataset containing 59928 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "DatasetKey is BIGOOD"
 ]
}

 The dataset includes 59928 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078539-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/whit-c170-97181
title: Dick Whittington Photography Collection, 1924-1987
DOI: 10.25549/whit-c170-104406
title: Cowgirl on horseback, Los Angeles County, Calif., 1941

description: 24 photographs of a cowgirl and a cowboy on horseback, Los Angeles County, California, 1941 July 21.