cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.2743279
title: Plectorthoid brachiopods from the Lower Ordovician of north-western Argentina; phylogenetic relationships with <i>Tarfaya</i> Havlíček and the origin of heterorthids

description: The re-study of species previously attributed to the genus <i>Nanorthis</i> from the Tremadocian of north-western Argentina has led to the recognition of the new genera <i>Gondwanorthis</i> (type species <i>Nanorthis calderensis</i> Benedetto), to which the Iranian species <i>Nanorthis bastamensis</i> Ghobadi Pour, Kebriaee-Zadeh & Popov is also referred, and <i>Lampazarorthis</i> (type species <i>Eoorthis bifurcata</i> Harrington), which includes <i>Nanorthis brachymyaria</i> Benedetto and <i>Lampazarorthis alata</i> sp<i>.</i> nov<i>.</i> New extensive collections from the Cordillera Oriental support reassignment of the upper Tremadocian species <i>Nanorthis purmamarcaensis</i> to the genus <i>Tarfaya</i>. The species <i>Nanorthis carinata</i> Laurie, from Tasmania, is reassigned here to <i>Tarfaya</i>. According to the present taxonomic revision, <i>Nanorthis</i> is not cosmopolitan but is a pan-tropical genus, confined to Laurentia, the Laurentian-derived Precordillera terrane, and probably to Baltica, Siberia and Kazakhstanian terranes, whereas <i>Gondwanorthis</i> and <i>Tarfaya</i> are Gondwanan and peri-Gondwanan endemic taxa. Cladistic analysis of early orthoids, plectorthoids and dalmanelloids, including those recorded from mid to high latitude Gondwana successions, portrays <i>Gondwanorthis</i> and <i>Lampazarorthis</i> as a sister group basal to the tarfayid + heterorthid clade, whereas the South American and North African <i>Incorthis</i> appears as a basal member of this clade. Morphological and stratigraphical evidence provided in this study, along with the results of the cladistic analysis, supports the view that heterorthids could have arisen from the tarfayids by the end of Floian. The enlargement and incipient bilobation of the cardinal process in <i>Tarfaya grandis</i> leaves this species as a potential ancestor of <i>Tissintia</i>, which occurs in Darriwilian beds of the Central Andean Basin (Bolivia), but could have been present in this basin since the late Floian. We speculate that punctae in the Heterorthidae evolved independently from a <i>Tarfaya-</i>like ancestor, and that the transition from an impunctate to a punctate shell may have occurred repeatedly through rhynchonelliform evolution. http://zoobank.org/urn:lsid:zoobank.org:pub:FFE818F6-FA92-4B26-AE76-077617C3D9EA
DOI: 10.6084/m9.figshare.2743669
title: Mechanisms regulating insulin response to intragastric glucose in lean and non-diabetic obese subjects

description: <b>Background/Objectives</b> The changes in blood glucose concentrations that result from an oral glucose challenge are dependent on the rate of gastric emptying, the rate of glucose absorption and the rate of insulin-driven metabolism that include the incretins, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). The rate of insulin-driven metabolism is clearly altered in obese subjects, but it is controversial which of these factors is predominant. We aimed to quantify gastric emptying, plasma insulin, C-peptide, glucagon and glucose responses, as well as incretin hormone secretions in obese subjects and healthy controls during increasing glucose loads. <b>Subjects/Methods</b> The study was conducted as a randomized, double-blind, parallel-group trial in a hospital research unit.<b> </b>A total of 12 normal weight (6 men and 6 women) and 12 non-diabetic obese (BMI &gt; 30, 6 men and 6 women) participants took part in the study. Subjects received intragastric<b> </b>loads of 10 g, 25 g and 75 g glucose dissolved in 300 ml tap water. <b>Results</b> Main outcome measures were plasma GLP-1 and GIP, plasma glucagon, glucose, insulin, C-peptide and gastric emptying. The primary findings are: i) insulin resistance (<i>P </i>&lt; 0.001) and hyperinsulinemia (<i>P </i>&lt; 0.001); ii) decreased insulin disposal (<i>P</i> &lt; 0.001); iii) trend for reduced GLP-1 responses at 75 g glucose; and iv) increased fasting glucagon levels (<i>P </i>&lt; 0.001) in obese subjects. <b>Conclusions</b> It seems that, rather than changes in incretin secretion, fasting hyperglucagonemia and consequent hyperglycemia play a role in reduced disposal of insulin, contributing to hyperinsulinemia and insulin resistance.
DOI: 10.6084/m9.figshare.2885308.v86
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2743279.v1
title: Plectorthoid brachiopods from the Lower Ordovician of north-western Argentina; phylogenetic relationships with <i>Tarfaya</i> Havlíček and the origin of heterorthids

description: The re-study of species previously attributed to the genus <i>Nanorthis</i> from the Tremadocian of north-western Argentina has led to the recognition of the new genera <i>Gondwanorthis</i> (type species <i>Nanorthis calderensis</i> Benedetto), to which the Iranian species <i>Nanorthis bastamensis</i> Ghobadi Pour, Kebriaee-Zadeh & Popov is also referred, and <i>Lampazarorthis</i> (type species <i>Eoorthis bifurcata</i> Harrington), which includes <i>Nanorthis brachymyaria</i> Benedetto and <i>Lampazarorthis alata</i> sp<i>.</i> nov<i>.</i> New extensive collections from the Cordillera Oriental support reassignment of the upper Tremadocian species <i>Nanorthis purmamarcaensis</i> to the genus <i>Tarfaya</i>. The species <i>Nanorthis carinata</i> Laurie, from Tasmania, is reassigned here to <i>Tarfaya</i>. According to the present taxonomic revision, <i>Nanorthis</i> is not cosmopolitan but is a pan-tropical genus, confined to Laurentia, the Laurentian-derived Precordillera terrane, and probably to Baltica, Siberia and Kazakhstanian terranes, whereas <i>Gondwanorthis</i> and <i>Tarfaya</i> are Gondwanan and peri-Gondwanan endemic taxa. Cladistic analysis of early orthoids, plectorthoids and dalmanelloids, including those recorded from mid to high latitude Gondwana successions, portrays <i>Gondwanorthis</i> and <i>Lampazarorthis</i> as a sister group basal to the tarfayid + heterorthid clade, whereas the South American and North African <i>Incorthis</i> appears as a basal member of this clade. Morphological and stratigraphical evidence provided in this study, along with the results of the cladistic analysis, supports the view that heterorthids could have arisen from the tarfayids by the end of Floian. The enlargement and incipient bilobation of the cardinal process in <i>Tarfaya grandis</i> leaves this species as a potential ancestor of <i>Tissintia</i>, which occurs in Darriwilian beds of the Central Andean Basin (Bolivia), but could have been present in this basin since the late Floian. We speculate that punctae in the Heterorthidae evolved independently from a <i>Tarfaya-</i>like ancestor, and that the transition from an impunctate to a punctate shell may have occurred repeatedly through rhynchonelliform evolution. http://zoobank.org/urn:lsid:zoobank.org:pub:FFE818F6-FA92-4B26-AE76-077617C3D9EA
DOI: 10.6084/m9.figshare.2743669.v2
title: Mechanisms regulating insulin response to intragastric glucose in lean and non-diabetic obese subjects

description: <b>Background/Objectives</b> The changes in blood glucose concentrations that result from an oral glucose challenge are dependent on the rate of gastric emptying, the rate of glucose absorption and the rate of insulin-driven metabolism that include the incretins, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). The rate of insulin-driven metabolism is clearly altered in obese subjects, but it is controversial which of these factors is predominant. We aimed to quantify gastric emptying, plasma insulin, C-peptide, glucagon and glucose responses, as well as incretin hormone secretions in obese subjects and healthy controls during increasing glucose loads. <b>Subjects/Methods</b> The study was conducted as a randomized, double-blind, parallel-group trial in a hospital research unit.<b> </b>A total of 12 normal weight (6 men and 6 women) and 12 non-diabetic obese (BMI &gt; 30, 6 men and 6 women) participants took part in the study. Subjects received intragastric<b> </b>loads of 10 g, 25 g and 75 g glucose dissolved in 300 ml tap water. <b>Results</b> Main outcome measures were plasma GLP-1 and GIP, plasma glucagon, glucose, insulin, C-peptide and gastric emptying. The primary findings are: i) insulin resistance (<i>P </i>&lt; 0.001) and hyperinsulinemia (<i>P </i>&lt; 0.001); ii) decreased insulin disposal (<i>P</i> &lt; 0.001); iii) trend for reduced GLP-1 responses at 75 g glucose; and iv) increased fasting glucagon levels (<i>P </i>&lt; 0.001) in obese subjects. <b>Conclusions</b> It seems that, rather than changes in incretin secretion, fasting hyperglucagonemia and consequent hyperglycemia play a role in reduced disposal of insulin, contributing to hyperinsulinemia and insulin resistance.
DOI: 10.6084/m9.figshare.2951263.v97
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.
DOI: 10.6084/m9.figshare.2742424
title: Characterization of biofilm formation in natural water subjected to low-frequency electromagnetic fields

description: Electromagnetic field (EMF) treatment has proven to be effective against mineral scaling in water systems. Therefore, it should be assessed for the treatment of other deposits such as biofilms. In this study, a commercial device producing low-frequency EMF (1–10 kHz) was applied to a reactor fed with natural water for 45 days. The treatment promoted the concentration of microorganisms in suspension and limited the amount of sessile microorganisms in the biofilm, as determined by the measurement of total DNA, qPCR and microscopy. The structure of the bacterial community was assessed by t-RFLP and pyrosequencing analysis. The results showed that EMF treatment affected both planktonic and sessile community composition. EMFs were responsible for a shift in classes of Proteobacteria during development of the biofilm. It may be speculated that the EMF treatment affected particle solubility and/or microorganism hydration. This study indicated that EMFs modulated biofilm formation in natural water.
DOI: 10.6084/m9.figshare.2743669.v1
title: rawdata_Glucose-DoseResponse.pdf

description: <b>Background/Objectives</b> The changes in blood glucose concentrations that result from an oral glucose challenge are dependent on the rate of gastric emptying, the rate of glucose absorption and the rate of insulin-driven metabolism that include the incretins, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). The rate of insulin-driven metabolism is clearly altered in obese subjects, but it is controversial which of these factors is predominant. We aimed to quantify gastric emptying, plasma insulin, C-peptide, glucagon and glucose responses, as well as incretin hormone secretions in obese subjects and healthy controls during increasing glucose loads. <b>Subjects/Methods</b> The study was conducted as a randomized, double-blind, parallel-group trial in a hospital research unit.<b> </b>A total of 12 normal weight (6 men and 6 women) and 12 non-diabetic obese (BMI &gt; 30, 6 men and 6 women) participants took part in the study. Subjects received intragastric<b> </b>loads of 10 g, 25 g and 75 g glucose dissolved in 300 ml tap water. <b>Results</b> Main outcome measures were plasma GLP-1 and GIP, plasma glucagon, glucose, insulin, C-peptide and gastric emptying. The primary findings are: i) insulin resistance (<i>P </i>&lt; 0.001) and hyperinsulinemia (<i>P </i>&lt; 0.001); ii) decreased insulin disposal (<i>P</i> &lt; 0.001); iii) trend for reduced GLP-1 responses at 75 g glucose; and iv) increased fasting glucagon levels (<i>P </i>&lt; 0.001) in obese subjects. <b>Conclusions</b> It seems that, rather than changes in incretin secretion, fasting hyperglucagonemia and consequent hyperglycemia play a role in reduced disposal of insulin, contributing to hyperinsulinemia and insulin resistance.
DOI: 10.6084/m9.figshare.2742424.v1
title: Characterization of biofilm formation in natural water subjected to low-frequency electromagnetic fields

description: Electromagnetic field (EMF) treatment has proven to be effective against mineral scaling in water systems. Therefore, it should be assessed for the treatment of other deposits such as biofilms. In this study, a commercial device producing low-frequency EMF (1–10 kHz) was applied to a reactor fed with natural water for 45 days. The treatment promoted the concentration of microorganisms in suspension and limited the amount of sessile microorganisms in the biofilm, as determined by the measurement of total DNA, qPCR and microscopy. The structure of the bacterial community was assessed by t-RFLP and pyrosequencing analysis. The results showed that EMF treatment affected both planktonic and sessile community composition. EMFs were responsible for a shift in classes of Proteobacteria during development of the biofilm. It may be speculated that the EMF treatment affected particle solubility and/or microorganism hydration. This study indicated that EMFs modulated biofilm formation in natural water.
DOI: 10.6084/m9.figshare.2741092
title: scorus_paper06-Data.doc

description: DATASET: Corine Land Covers within a radius of 0.2º around the median position of each individual woodcock at each stopover site.
DOI: 10.6084/m9.figshare.2741092.v1
title: scorus_paper06-Data.doc

description: DATASET: Corine Land Covers within a radius of 0.2º around the median position of each individual woodcock at each stopover site.
DOI: 10.6084/m9.figshare.2885308.v87
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2729782
title: Raw data of S. mentella parasite community analysis

description: <b></b>Host biometric and parasite analysis raw data. TL= Total Length, TW= Total Weight, SL= Standard Length
DOI: 10.6084/m9.figshare.2728588
title: SIB_virtualseminar_Dec2015.pdf

description: Slides from presentation to the Swiss Institute of Bioinformatics (SIB) "Virtual Seminars" series:<br>"Integration of RNA-Seq big data in Bgee. How to not throw away Terabytes of publicly-funded data"<br>by Frédéric Bastian<br><br>
DOI: 10.6084/m9.figshare.2885308.v88
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2951263.v98
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.
DOI: 10.6084/m9.figshare.2729782.v1
title: Raw data of S. mentella parasite community analysis

description: <b></b>Host biometric and parasite analysis raw data. TL= Total Length, TW= Total Weight, SL= Standard Length
DOI: 10.6084/m9.figshare.2728588.v2
title: SIB_virtualseminar_Dec2015.pdf

description: Slides from presentation to the Swiss Institute of Bioinformatics (SIB) "Virtual Seminars" series:<br>"Integration of RNA-Seq big data in Bgee. How to not throw away Terabytes of publicly-funded data"<br>by Frédéric Bastian<br><br>
DOI: 10.6084/m9.figshare.2951263.v99
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.
DOI: 10.6084/m9.figshare.2885308.v89
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2703340
title: Book1.xlsx

description: This is just a test data<br>
DOI: 10.6084/m9.figshare.2703340.v1
title: Book1.xlsx

description: This is just a test data<br>
DOI: 10.6084/m9.figshare.2951263.v100
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.
DOI: 10.6084/m9.figshare.2729782.v2
title: Raw data of S. mentella parasite community analysis

description: <b></b>Host biometric and parasite analysis raw data. TL= Total Length, TW= Total Weight, SL= Standard Length
DOI: 10.6084/m9.figshare.2885308.v90
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2695480
title: mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

description: <b>Background</b>: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and glioma treatment remain unclear. <b>Methods</b>: <i>SOX2</i> and <i>SOX9</i> levels were examined in human biopsies. Gain and loss of function determined the impact of altering SOX2 and SOX9 on cell proliferation, senescence, stem cell activity, tumorigenesis and chemoresistance. <b>Results</b>: SOX2 and SOX9 expression correlates positively in glioma cells and glioblastoma biopsies. High levels of SOX2 bypass cellular senescence and promote resistance to temozolomide. Mechanistic investigations revealed that SOX2 acts upstream of SOX9. mTOR genetic and pharmacologic (rapamycin) inhibition decreased SOX2 and SOX9 expression, and reversed chemoresistance. <b>Conclusions</b>: Our findings reveal SOX2-SOX9 as an oncogenic axis that regulates stem cell properties and chemoresistance. We identify that rapamycin abrogate SOX protein expression and provide evidence that a combination of rapamycin and temozolomide inhibits tumor growth in cells with high SOX2/SOX9.
DOI: 10.6084/m9.figshare.2695480.v1
title: mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

description: <b>Background</b>: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and glioma treatment remain unclear. <b>Methods</b>: <i>SOX2</i> and <i>SOX9</i> levels were examined in human biopsies. Gain and loss of function determined the impact of altering SOX2 and SOX9 on cell proliferation, senescence, stem cell activity, tumorigenesis and chemoresistance. <b>Results</b>: SOX2 and SOX9 expression correlates positively in glioma cells and glioblastoma biopsies. High levels of SOX2 bypass cellular senescence and promote resistance to temozolomide. Mechanistic investigations revealed that SOX2 acts upstream of SOX9. mTOR genetic and pharmacologic (rapamycin) inhibition decreased SOX2 and SOX9 expression, and reversed chemoresistance. <b>Conclusions</b>: Our findings reveal SOX2-SOX9 as an oncogenic axis that regulates stem cell properties and chemoresistance. We identify that rapamycin abrogate SOX protein expression and provide evidence that a combination of rapamycin and temozolomide inhibits tumor growth in cells with high SOX2/SOX9.
DOI: 10.6084/m9.figshare.2951263.v101
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.
DOI: 10.6084/m9.figshare.2729782.v3
title: Raw data of S. mentella parasite community analysis

description: <b></b>Host biometric and parasite analysis raw data. TL= Total Length, TW= Total Weight, SL= Standard Length
DOI: 10.17633/rd.brunel.2686381
title: Understanding weight loss in obese adults

description: This data consists of qualitative data from interviews with 15 participants. The participants were split into two groups - the 'lost group consisted of those who were or had been obese and who had lost at least 8kgs within the last 3 years and those who were obese and who had not last 8kgs within the last 3 years. Thematic Analysis was used to develop themes. The clustered quotes which support the themes are presented in the attachment. Themes include: the catalyst for weight loss, the mindset, and support (from health professionals and friends and family).
DOI: 10.6084/m9.figshare.2885308.v91
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2951263.v102
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.
DOI: 10.17633/rd.brunel.2686381.v1
title: Understanding weight loss in obese adults

description: This data consists of qualitative data from interviews with 15 participants. The participants were split into two groups - the 'lost group consisted of those who were or had been obese and who had lost at least 8kgs within the last 3 years and those who were obese and who had not last 8kgs within the last 3 years. Thematic Analysis was used to develop themes. The clustered quotes which support the themes are presented in the attachment. Themes include: the catalyst for weight loss, the mindset, and support (from health professionals and friends and family).
DOI: 10.6084/m9.figshare.2885308.v92
title: UNH-RVAT 3-D SST RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions using the k-omega SST RANS model in OpenFOAM 2.3.x. See the link below for case files and download instructions.
DOI: 10.6084/m9.figshare.2951263.v103
title: UNH-RVAT 3-D Spalart--Allmaras RANS simulation results

description: Results from simulating the UNH-RVAT cross-flow turbine in three dimensions with the Spalart--Allmaras RANS model in OpenFOAM 2.3.x (590d57f32fed). See link below for case files (note: use the `SpalartAllmaras` branch), which include a script for downloading and extracting, as well as scripts for post-processing.