cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21907692.v1
title: Evaluation of the national information security policy by analytic hierarchy process

description: ABSTRACT Recent cybersecurity reports show that Brazil is one of the countries with the highest number of cybercrimes, affecting more than 60 million people and causing losses estimated at more than 20 billion dollars. Within the scope of the Public Administration, the National Information Security Policy (PNSI) assigned to the Institutional Security Office of the Presidency (GSI/PR) the task of monitoring and evaluating its execution, stimulating the broad participation of society and agencies and public authorities in the construction of the process, which includes the academic effort. To contribute to this context, this research analyzed different reference models, whose structure best suited the needs of the institutions evaluated and a quantitative method capable of objectively indicating the weight of the various variables in the model. The maturity model chosen was the CSF-NIST and the method selected was the Analytic Hierarchy Process (AHP), for weighting the criteria and sub criteria. A case study illustrates the application of the selected model and method, indicating “how” to implement them, considering the specificities of the evaluated institution.
DOI: 10.6084/m9.figshare.21907695
title: What do children aged 5 to 14 years die from in the state of Rio de Janeiro, Brazil? Trend analysis of the period 2000-2019

description: Abstract This study investigated the magnitude and trends of cause-specific mortality among children 5 to 14 years of age in the state of Rio de Janeiro (RJ) from 2000 to 2019. We performed an ecological study, using data from the Mortality Information System (MIS). We calculated mortality rates per 100,000 children by chapters, groups, and categories of causes of death (ICD-10). Trends were estimated by joinpoint regression. Mortality rates among children aged 10 to 14 years were higher than those among children 5 to 9. The five leading causes of death were the same in both age groups, but they ranked differently. The two leading ones were external causes and neoplasms (31% and 15% among children aged 5 to 9 years; 45% and 11% among children aged 10 to 14 years). Among children 5 to 9 years, the mortality trend showed an annual decline (8%) from 2011 to 2015. Among children aged 10 to 14 years, the annual decline was 1.3% from 2000 to 2019. Mortality due to external causes decreased in both age groups, except for the category “Assault by unspecified firearm” (boys, 10 to 14 years) and “Unspecified drowning and submersion” (boys, 5 to 9 years). Mortality caused by neoplasms remained steady in both age groups. Infectious and respiratory diseases decreased differently between the two groups. Most causes of death are preventable or treatable, indicating the need for health and intersectoral investments.
DOI: 10.6084/m9.figshare.21907695.v1
title: What do children aged 5 to 14 years die from in the state of Rio de Janeiro, Brazil? Trend analysis of the period 2000-2019

description: Abstract This study investigated the magnitude and trends of cause-specific mortality among children 5 to 14 years of age in the state of Rio de Janeiro (RJ) from 2000 to 2019. We performed an ecological study, using data from the Mortality Information System (MIS). We calculated mortality rates per 100,000 children by chapters, groups, and categories of causes of death (ICD-10). Trends were estimated by joinpoint regression. Mortality rates among children aged 10 to 14 years were higher than those among children 5 to 9. The five leading causes of death were the same in both age groups, but they ranked differently. The two leading ones were external causes and neoplasms (31% and 15% among children aged 5 to 9 years; 45% and 11% among children aged 10 to 14 years). Among children 5 to 9 years, the mortality trend showed an annual decline (8%) from 2011 to 2015. Among children aged 10 to 14 years, the annual decline was 1.3% from 2000 to 2019. Mortality due to external causes decreased in both age groups, except for the category “Assault by unspecified firearm” (boys, 10 to 14 years) and “Unspecified drowning and submersion” (boys, 5 to 9 years). Mortality caused by neoplasms remained steady in both age groups. Infectious and respiratory diseases decreased differently between the two groups. Most causes of death are preventable or treatable, indicating the need for health and intersectoral investments.
DOI: 10.6084/m9.figshare.21907699
title: The Effect of Anakinra on Acrylamide-induced Peripheral Neuropathy and Neuropathic Pain in Rats

description: Abstract Acrylamide is a neurotoxic compound. Moreover, anakinra is an interleukin-1 (IL-1) receptor antagonist used in rheumatoid arthritis treatment. This study investigated the effect of anakinra on acrylamide-related neuropathy and neuropathic pain. Acrylamide exposure caused a significant decrease in the pain threshold; an increase in malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) levels; and a decrease in total glutathione (tGSH) values in the sciatic nerve. This indicates hyperalgesia presence, oxidative stress, and peripheral nerve tissue inflammation. Anakinra treatment significantly reduced the MDA, IL-1β, and TNF-α levels, and increased the pain threshold and mean tGSH values. The analgesic effect of anakinra was 67.9% at the first hour, increasing to 74.9% and 76.7% at the second and third hours, respectively. The group receiving acrylamide exhibited histopathological changes (e.g., swollen and degenerated axons, hypertrophic and hyperplasic Schwann cells, and congested vessels). The use of anakinra significantly improved these morphological changes. Anakinra is concluded to reduce neuropathic pain and prevent neurotoxic effect of acrylamide on peripheral nerves due to its analgesic, antioxidant, and anti-inflammatory properties.
DOI: 10.6084/m9.figshare.21907699.v1
title: The Effect of Anakinra on Acrylamide-induced Peripheral Neuropathy and Neuropathic Pain in Rats

description: Abstract Acrylamide is a neurotoxic compound. Moreover, anakinra is an interleukin-1 (IL-1) receptor antagonist used in rheumatoid arthritis treatment. This study investigated the effect of anakinra on acrylamide-related neuropathy and neuropathic pain. Acrylamide exposure caused a significant decrease in the pain threshold; an increase in malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) levels; and a decrease in total glutathione (tGSH) values in the sciatic nerve. This indicates hyperalgesia presence, oxidative stress, and peripheral nerve tissue inflammation. Anakinra treatment significantly reduced the MDA, IL-1β, and TNF-α levels, and increased the pain threshold and mean tGSH values. The analgesic effect of anakinra was 67.9% at the first hour, increasing to 74.9% and 76.7% at the second and third hours, respectively. The group receiving acrylamide exhibited histopathological changes (e.g., swollen and degenerated axons, hypertrophic and hyperplasic Schwann cells, and congested vessels). The use of anakinra significantly improved these morphological changes. Anakinra is concluded to reduce neuropathic pain and prevent neurotoxic effect of acrylamide on peripheral nerves due to its analgesic, antioxidant, and anti-inflammatory properties.
DOI: 10.6084/m9.figshare.21835122
title: Transcriptome analysis during fruit developmental stages in durian (Durio zibethinus Murr.) var. D24

description: Abstract Durian (Durio zibethinus Murr.) fruits are famous for their unique aroma. This study analysed the Durian fruit transcriptome to discover the expression patterns of genes and to understand their regulation. Three developmental stages of Durian fruit, namely, early [90 days post-anthesis (DPA)], mature (120 DPA), and ripen (127 DPA), were studied. The Illumina HiSeq platform was used for sequencing. The sequence data were analysed using four different mapping aligners and statistical methods: CLC Genomic Workbench, HISAT2+DESeq2, Tophat+Cufflinks, and HISAT2+edgeR. The analyses showed that over 110 million clean reads were mapped to the Durian genome, yielding 19,976, 11,394, 17,833, and 24,351 differentially expressed genes during 90-127 days post-anthesis. Many identified differentially expressed genes were linked to the fruit ripening processes. The data analysis suggests that most genes with increased expression at the ripening stage were primarily involved in the metabolism of cofactors and vitamins, nucleotide metabolism, and carbohydrate metabolism. Significantly expressed genes from the young to mature stage were mainly associated with carbohydrate metabolism, amino acid metabolism, and cofactor and vitamin metabolism. The transcriptome data will serve as a foundation for understanding Durian fruit development-specific genes and could be helpful in fruit’s trait improvement.
DOI: 10.6084/m9.figshare.21835122.v1
title: Transcriptome analysis during fruit developmental stages in durian (Durio zibethinus Murr.) var. D24

description: Abstract Durian (Durio zibethinus Murr.) fruits are famous for their unique aroma. This study analysed the Durian fruit transcriptome to discover the expression patterns of genes and to understand their regulation. Three developmental stages of Durian fruit, namely, early [90 days post-anthesis (DPA)], mature (120 DPA), and ripen (127 DPA), were studied. The Illumina HiSeq platform was used for sequencing. The sequence data were analysed using four different mapping aligners and statistical methods: CLC Genomic Workbench, HISAT2+DESeq2, Tophat+Cufflinks, and HISAT2+edgeR. The analyses showed that over 110 million clean reads were mapped to the Durian genome, yielding 19,976, 11,394, 17,833, and 24,351 differentially expressed genes during 90-127 days post-anthesis. Many identified differentially expressed genes were linked to the fruit ripening processes. The data analysis suggests that most genes with increased expression at the ripening stage were primarily involved in the metabolism of cofactors and vitamins, nucleotide metabolism, and carbohydrate metabolism. Significantly expressed genes from the young to mature stage were mainly associated with carbohydrate metabolism, amino acid metabolism, and cofactor and vitamin metabolism. The transcriptome data will serve as a foundation for understanding Durian fruit development-specific genes and could be helpful in fruit’s trait improvement.
DOI: 10.6084/m9.figshare.21907702
title: Design of experiments assisted the development of inclusion complexes of ramipril using hydrophilic carriers for enhancement of solubility and dissolution rate

description: Abstract The goal of the present study was to develop inclusion complexes and polymers dispersions of ramipril prepared by physical mixing, kneading, co-evaporation, and solvent evaporation methods to enhance drug solubility and dissolution rate, and thereby to reduce drug dose and side effects using selected hydrophilic carriers such as β-CD, PVP-K25, PEG 4000, and HPMC K100M. The prepared formulations were characterized for solubility and in-vitro drug release studies. The systematic optimization of formulations was performed using I-Optimal experimental design by selecting factors such as type of carriers (X1), drug: carrier ratio (X2), and method of preparation (X3), and response variables including percent yield (Y1), solubility (Y2), Carr’s index (Y3) and drug release in 30 min (Y4). Mathematical modeling was carried out using a quadratic polynomial model. The inclusion complex formulation (F27) was selected as an optimized batch by numerical desirability function and graphical optimization with the help of design space. The inclusion complex prepared by the co-evaporation method showed maximum drug solubility and released in pH 6.8 phosphate buffer compared to pure and other formulations. The inclusion complex is a feasible approach to improve the solubility, dissolution rate, bioavailability, and minimization of drugs’ gastrointestinal toxicity upon oral administration of ramipril.
DOI: 10.6084/m9.figshare.21907702.v1
title: Design of experiments assisted the development of inclusion complexes of ramipril using hydrophilic carriers for enhancement of solubility and dissolution rate

description: Abstract The goal of the present study was to develop inclusion complexes and polymers dispersions of ramipril prepared by physical mixing, kneading, co-evaporation, and solvent evaporation methods to enhance drug solubility and dissolution rate, and thereby to reduce drug dose and side effects using selected hydrophilic carriers such as β-CD, PVP-K25, PEG 4000, and HPMC K100M. The prepared formulations were characterized for solubility and in-vitro drug release studies. The systematic optimization of formulations was performed using I-Optimal experimental design by selecting factors such as type of carriers (X1), drug: carrier ratio (X2), and method of preparation (X3), and response variables including percent yield (Y1), solubility (Y2), Carr’s index (Y3) and drug release in 30 min (Y4). Mathematical modeling was carried out using a quadratic polynomial model. The inclusion complex formulation (F27) was selected as an optimized batch by numerical desirability function and graphical optimization with the help of design space. The inclusion complex prepared by the co-evaporation method showed maximum drug solubility and released in pH 6.8 phosphate buffer compared to pure and other formulations. The inclusion complex is a feasible approach to improve the solubility, dissolution rate, bioavailability, and minimization of drugs’ gastrointestinal toxicity upon oral administration of ramipril.
DOI: 10.6084/m9.figshare.21907705
title: Oxyfluorfen bioavailability in Brazilian Savanna soils

description: ABSTRACT Oxyfluorfen is a pre-emergent herbicide applied via soil; however, the soil attributes have not been considered to predict the herbicide doses. This study aimed to evaluate the bioavailability of the oxyfluorfen herbicide in Brazilian Savanna soils with contrasting attributes. The experiment was carried out in a 6 x 8 factorial scheme, with 6 replications. The evaluated factors were soil types [Gleissolo Melânico distrófico - GMd (Typic Humaquept); Latossolo Vermelho ácrico - LVw (Rhodic Acrustox); Latossolo Vermelho distrófico - LVd (Rhodic Haplustox); Neossolo Quartzarênico órtico - RQo (Typic Quartzpsamment); Neossolo Flúvico Tb distrófico - RYbd (Fluventic Dystrustept); and washed sand] and oxyfluorfen doses (0; 360; 480; 720; 1,440; 2,880; 4,320; and 5,760 g a.i. ha-1). The herbicide bioavailability was determined according to the bioassay methodology. The dose that provided 80 % of Cucumis sativum control (C80%) ranged from 9.9 (LVw) to 1,884.4 g a.i. ha-1 (GMd), what can be attributed to the high sorption of the herbicide in the GMd, as observed by the adsorptive rate. The soil texture did not show correlation with the oxyfluorfen bioavailability. In the LVd, which is from the same order and with texture similar to that of the LVw, the C80% was 76 times higher (754.28 g a.i. ha-1). Furthermore, for the RYbd, which is a sandy soil, the C80% was even high (1,256.9 g a.i. ha-1). The cation exchange capacity (CEC) (-0.83**) was the only soil attribute able to predict the herbicide bioavailability. The oxyfluorfen bioavailability is highly dependent on the soil attributes, and, in Brazilian Savanna soils, it can be predicted using the CEC.
DOI: 10.6084/m9.figshare.21907705.v1
title: Oxyfluorfen bioavailability in Brazilian Savanna soils

description: ABSTRACT Oxyfluorfen is a pre-emergent herbicide applied via soil; however, the soil attributes have not been considered to predict the herbicide doses. This study aimed to evaluate the bioavailability of the oxyfluorfen herbicide in Brazilian Savanna soils with contrasting attributes. The experiment was carried out in a 6 x 8 factorial scheme, with 6 replications. The evaluated factors were soil types [Gleissolo Melânico distrófico - GMd (Typic Humaquept); Latossolo Vermelho ácrico - LVw (Rhodic Acrustox); Latossolo Vermelho distrófico - LVd (Rhodic Haplustox); Neossolo Quartzarênico órtico - RQo (Typic Quartzpsamment); Neossolo Flúvico Tb distrófico - RYbd (Fluventic Dystrustept); and washed sand] and oxyfluorfen doses (0; 360; 480; 720; 1,440; 2,880; 4,320; and 5,760 g a.i. ha-1). The herbicide bioavailability was determined according to the bioassay methodology. The dose that provided 80 % of Cucumis sativum control (C80%) ranged from 9.9 (LVw) to 1,884.4 g a.i. ha-1 (GMd), what can be attributed to the high sorption of the herbicide in the GMd, as observed by the adsorptive rate. The soil texture did not show correlation with the oxyfluorfen bioavailability. In the LVd, which is from the same order and with texture similar to that of the LVw, the C80% was 76 times higher (754.28 g a.i. ha-1). Furthermore, for the RYbd, which is a sandy soil, the C80% was even high (1,256.9 g a.i. ha-1). The cation exchange capacity (CEC) (-0.83**) was the only soil attribute able to predict the herbicide bioavailability. The oxyfluorfen bioavailability is highly dependent on the soil attributes, and, in Brazilian Savanna soils, it can be predicted using the CEC.
DOI: 10.6084/m9.figshare.21856140
title: Optimum design of prestressed steel beams via genetic algorithm

description: Abstract The objective of this article is to present an optimization problem formulation to reduce the total structural cost of prestressed doubly-symmetric and monosymmetric I-shaped steel simply supported beams with straight tendons. The optimization problem was implemented via MATLAB’s native Genetic Algorithm. The validation and evaluation processes adopted two examples from literature. The design method follows the Brazilian standard NBR 8800:2008 for the Ultimate and Serviceability Limit States. The best result was found for a monosymmetric case by up to 20.00% and 25.70%. Saving in material weight and installation of tendons, without exceeding the security limits, was also effective. Furthermore, the results presented an efficient alternative for structural engineering, providing a significant model for similar analyzes.
DOI: 10.6084/m9.figshare.21856140.v1
title: Optimum design of prestressed steel beams via genetic algorithm

description: Abstract The objective of this article is to present an optimization problem formulation to reduce the total structural cost of prestressed doubly-symmetric and monosymmetric I-shaped steel simply supported beams with straight tendons. The optimization problem was implemented via MATLAB’s native Genetic Algorithm. The validation and evaluation processes adopted two examples from literature. The design method follows the Brazilian standard NBR 8800:2008 for the Ultimate and Serviceability Limit States. The best result was found for a monosymmetric case by up to 20.00% and 25.70%. Saving in material weight and installation of tendons, without exceeding the security limits, was also effective. Furthermore, the results presented an efficient alternative for structural engineering, providing a significant model for similar analyzes.
DOI: 10.6084/m9.figshare.21907711
title: Duguetia leucotricha (Annonaceae), a new species from the Atlantic Coastal Forest of Brazil

description: Abstract A new species of Annonaceae, Duguetia leucotricha M.L.Bazante & Maas, from lowland to submontane forests of southern Bahia, Brazil, is described. It differs from other species of the genus mainly by the dense greyish white stellate hairs on vegetative and reproductive structures, rather widely-spaced flowers, the large bract in the upper part of the well-developed pedicel, sepals and petals almost equal in length, and the few-carpellate fruits with rounded apex of the areoles. Commentaries concerning its morphological aspects and relationships of affinity, geographic distribution, conservation status and photos are provided, as well as a key to all Atlantic Coastal Forest species of Duguetia.
DOI: 10.6084/m9.figshare.21907711.v1
title: Duguetia leucotricha (Annonaceae), a new species from the Atlantic Coastal Forest of Brazil

description: Abstract A new species of Annonaceae, Duguetia leucotricha M.L.Bazante & Maas, from lowland to submontane forests of southern Bahia, Brazil, is described. It differs from other species of the genus mainly by the dense greyish white stellate hairs on vegetative and reproductive structures, rather widely-spaced flowers, the large bract in the upper part of the well-developed pedicel, sepals and petals almost equal in length, and the few-carpellate fruits with rounded apex of the areoles. Commentaries concerning its morphological aspects and relationships of affinity, geographic distribution, conservation status and photos are provided, as well as a key to all Atlantic Coastal Forest species of Duguetia.
DOI: 10.6084/m9.figshare.21907557
title: EV energy Demand Forecasting

description: The dataset comprises EV energy demand focasting
DOI: 10.6084/m9.figshare.21907716
title: Dental visits and depression mediating the association of socioeconomic status with oral health behaviors

description: Abstract Determinants of oral diseases include behaviors, which in turn are influenced by a series of social determinants such as psychosocial aspects and dental care services. Therefore, the aim of this study was to investigate whether depressive symptoms and use of dental care services mediate the relationship between socioeconomic status (SES) and oral health behaviors. This was a cross-sectional study that analyzed data from participants in the 2019 National Health Survey (PNS) (n = 88,531). The eligibility criteria were individuals who were 18 years and older and exclusion criterion was living in households located in special or sparsely populated census tracts. Structural equation modeling (SEM) was used to test direct and indirect pathways from a latent variable for SES to oral health through depressive symptoms (assessed through the “Patient Health Questionnaire-9”) and use of dental care services. The maximum likelihood estimator for complex samples with the robust standard error was used. The final model presented an adequate fit: RMESA of 0.008, CFI of 0.998, and SMRM of 0.005. The results showed that higher SES was directly associated with better oral health-related behaviors [standardized coefficient (SC): 0.428; p &lt; 0.01] and indirectly through depressive symptoms [(SC): 0.002; p &lt; 0.01] and dental care services [(SC): 0.089; p &lt; 0.01]. The total effect of SES on oral health-related behaviors was equal to [(SC: 0.519 (p &lt; 0.01)]. In conclusion, the findings suggest that high socioeconomic status, mediated by depressive symptoms and dental care services, has a positive effect on oral health.