cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3465356
title: Supplementary Material for: Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes

description: <b><i>Background:</i></b> This study investigated the effect of lithium monotherapy on peripheral lymphocyte gene expression in bipolar disorder (BD). <b><i>Method:</i></b> Twenty-two medication-free bipolar subjects (11 hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were included as controls but did not receive treatment. Blood RNA samples were collected at baseline and after 2 and 8 weeks of treatment. RNA expression was measured using the Affymetrix GeneChip® Human Gene 1.0 ST Array followed by Ingenuity pathways analysis. The results for the contrast of weeks 2 and 8 were not significantly different and were combined. <b><i>Results:</i></b> In BD subjects, 56 genes showed significant (false discovery rate &lt;0.1) expression changes from baseline; the effect sizes and directions for all of these were similar at weeks 2 and 8. Among these were immune-related genes (IL5RA, MOK, IFI6, and RFX2), purinergic receptors (P2RY14, P2RY2, and ADORA3) and signal transduction-related genes (CAMK1 and PIK3R6). Pathway and upstream regulator analysis also revealed that lithium altered several immune- and signal transduction-related functions. Differentially expressed genes did not correlate with week 8 clinical response, but other genes involved in protein synthesis and degradation did. <b><i>Conclusion:</i></b> Peripheral gene expression may serve as a biomarker of lithium effect.
DOI: 10.6084/m9.figshare.3465320
title: PubMed Central, Table 2_ Front Immunol. 2013; 4_ 248. Published online 2013 Sep 2. doi_ 10.3389_fimmu.2013.00248.html

description: <strong>Sensing of SCPs by cytosolic PRRs</strong>.
DOI: 10.6084/m9.figshare.3465320.v1
title: PubMed Central, Table 2_ Front Immunol. 2013; 4_ 248. Published online 2013 Sep 2. doi_ 10.3389_fimmu.2013.00248.html

description: <strong>Sensing of SCPs by cytosolic PRRs</strong>.
DOI: 10.6084/m9.figshare.3465308
title: PubMed Central, Table 1_ Front Immunol. 2013; 4_ 248. Published online 2013 Sep 2. doi_ 10.3389_fimmu.2013.00248.html

description: <strong>Sensing of SCPs by plasma membrane localized PRRs</strong>.
DOI: 10.6084/m9.figshare.3465308.v1
title: PubMed Central, Table 1_ Front Immunol. 2013; 4_ 248. Published online 2013 Sep 2. doi_ 10.3389_fimmu.2013.00248.html

description: <strong>Sensing of SCPs by plasma membrane localized PRRs</strong>.
DOI: 10.6084/m9.figshare.3465233
title: Supplementary Material for: Increased Levels of Copeptin, a Surrogate Marker of Arginine Vasopressin, Are Associated with an Increased Risk of Chronic Kidney Disease in a General Population

description: <i>Background:</i> Our aim was to test if plasma copeptin, a stable surrogate marker of arginine vasopressin, predicts decline of glomerular filtration rate (GFR) and risk of chronic kidney disease (CKD). <i>Methods:</i> We measured copeptin and renal function at the Malmö Diet and Cancer Cardiovascular Cohort baseline exam and reassessed renal function after a follow-up time of 16.6 ± 1.5 years (n = 3,186). Furthermore, we defined CKD based on an estimated GFR (eGFR) calculated by the Modification of Diet in Renal Disease (MDRD) &lt;60 (CKD_60MDRD), &lt;45 (CKD_45MDRD) and &lt;30 (CKD_30MDRD) ml/min/1.73 m2. <i>Results:</i> After multivariate adjustment (gender, age, baseline eGFR, smoking status, systolic blood pressure, antihypertensive treatment and follow-up time), copeptin (beta-coefficient per 1 SD increment of copeptin) was independently associated with significantly greater annual decline of eGFR (ml/min/1.73 m2) according to the MDRD formula (OR 0.057, 95% CI 0.022-0.093; p = 0.001) as well as according to the CKD Epidemiology Collaboration (CKD-EPI) formula (OR 0.050, 95% CI 0.022-0.077; p &lt; 0.001). Each SD increment of copeptin independently predicted incident CKD_60MDRD (OR 1.19, 95% CI 1.04-1.36; p = 0.010), CKD_45MDRD (OR 1.33, 95% CI 1.04-1.71; p = 0.026) and CKD_30MDRD (OR 3.69, 95% CI 1.41-9.66; p = 0.008). The relationship between copeptin and CKD defined by CKD-EPI gave similar results. <i>Conclusion:</i> Our data suggest that increased levels of copeptin independently predict decline in eGFR and greater risk of new-onset CKD.
DOI: 10.6084/m9.figshare.3465209
title: Supplementary Material for: Dispatcher Stroke Recognition Using a Stroke Screening Tool: A Systematic Review

description: <i>Background:</i> Emergency dispatchers represent the first point of contact for patients activating an acute stroke response. Accurate dispatcher stroke recognition is associated with faster emergency medical services response time; however, stroke is often unrecognized during initial emergency calls. Stroke screening tools such as the Cincinnati Prehospital Stroke Scale have been shown to improve on-scene stroke recognition and thus have been proposed as a means to improve dispatcher accuracy. We conducted a systematic review of the accuracy of emergency dispatcher stroke recognition when employing stroke screening tools. <i>Methods:</i> We conducted a comprehensive search of Medline, EMBASE, CINAHL, and Cochrane databases to identify studies of dispatcher stroke recognition accuracy. Those that specifically reported dispatcher utilization of any validated stroke screening tools in isolation or in the context of a comprehensive screening algorithm such as the Medical Priority Dispatch System (MPDS) were potentially eligible. Studies that reported data sufficient for calculation of dispatcher sensitivity or positive predictive value (PPV) using a hospital-based stroke/transient ischemic attack diagnosis as the reference standard were included. Two independent reviewers determined study eligibility, assessed quality using the QUADAS 2 instrument, and abstracted data. <i>Results:</i> We identified 1,413 potential studies; 54 underwent full text review. Three retrospective and 4 prospective cohort studies enrolling a total of 16,382 patients met the inclusion criteria. Stroke screening tools included MPDS (n = 4), Face Arm Speech Time (n = 2), and a novel screening algorithm developed after analysis of emergency calls for stroke (n = 1). Regardless of the screening tool employed, dispatcher stroke recognition sensitivity was suboptimal (5 studies, range 41-83%) as was the PPV (7 studies, range 42-68%). Primary study limitations included application of variable reference standards and questions regarding exclusion of subjects. No studies directly compared stroke screening algorithms and no studies specifically examined stroke recognition among potential candidates for acute stroke therapies.<i>Conclusion:</i> Even when utilizing a stroke screening tool, the accuracy of stroke recognition by emergency dispatchers was suboptimal. More research is needed to identify the causes of poor dispatcher stroke recognition and should focus on potential candidates for time-dependent stroke treatment.
DOI: 10.6084/m9.figshare.3465209.v1
title: Supplementary Material for: Dispatcher Stroke Recognition Using a Stroke Screening Tool: A Systematic Review

description: <i>Background:</i> Emergency dispatchers represent the first point of contact for patients activating an acute stroke response. Accurate dispatcher stroke recognition is associated with faster emergency medical services response time; however, stroke is often unrecognized during initial emergency calls. Stroke screening tools such as the Cincinnati Prehospital Stroke Scale have been shown to improve on-scene stroke recognition and thus have been proposed as a means to improve dispatcher accuracy. We conducted a systematic review of the accuracy of emergency dispatcher stroke recognition when employing stroke screening tools. <i>Methods:</i> We conducted a comprehensive search of Medline, EMBASE, CINAHL, and Cochrane databases to identify studies of dispatcher stroke recognition accuracy. Those that specifically reported dispatcher utilization of any validated stroke screening tools in isolation or in the context of a comprehensive screening algorithm such as the Medical Priority Dispatch System (MPDS) were potentially eligible. Studies that reported data sufficient for calculation of dispatcher sensitivity or positive predictive value (PPV) using a hospital-based stroke/transient ischemic attack diagnosis as the reference standard were included. Two independent reviewers determined study eligibility, assessed quality using the QUADAS 2 instrument, and abstracted data. <i>Results:</i> We identified 1,413 potential studies; 54 underwent full text review. Three retrospective and 4 prospective cohort studies enrolling a total of 16,382 patients met the inclusion criteria. Stroke screening tools included MPDS (n = 4), Face Arm Speech Time (n = 2), and a novel screening algorithm developed after analysis of emergency calls for stroke (n = 1). Regardless of the screening tool employed, dispatcher stroke recognition sensitivity was suboptimal (5 studies, range 41-83%) as was the PPV (7 studies, range 42-68%). Primary study limitations included application of variable reference standards and questions regarding exclusion of subjects. No studies directly compared stroke screening algorithms and no studies specifically examined stroke recognition among potential candidates for acute stroke therapies.<i>Conclusion:</i> Even when utilizing a stroke screening tool, the accuracy of stroke recognition by emergency dispatchers was suboptimal. More research is needed to identify the causes of poor dispatcher stroke recognition and should focus on potential candidates for time-dependent stroke treatment.
DOI: 10.6084/m9.figshare.3465083
title: Global_Treg_research_in_the_period_of_2000-2015

description: the data set of Global Regulatory T-Cell Research from 2000 to 2015
DOI: 10.6084/m9.figshare.3465083.v1
title: Global_Treg_research_in_the_period_of_2000-2015

description: the data set of Global Regulatory T-Cell Research from 2000 to 2015
DOI: 10.6084/m9.figshare.3464945
title: Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeast <i>Candida glabrata</i>

description: <i>Candida glabrata</i>, a haploid budding yeast, is the cause of severe systemic infections in immune-compromised hosts. The amount of free iron supplied to <i>C. glabrata</i> cells during systemic infections is severely limited by iron-chelating proteins such as transferrin. Thus, the iron-deficiency response in <i>C. glabrata</i> cells is thought to play important roles in their survival inside the host's body. In this study, we found that mitophagy was induced under iron-depleted conditions, and that the disruption of a gene homologous to <i>ATG32</i>, which is responsible for mitophagy in <i>Saccharomyces cerevisiae</i>, blocked mitophagy in <i>C. glabrata</i>. The mitophagic activity in <i>C. glabrata</i> cells was not detected on short-period exposure to nitrogen-starved conditions, which is a mitophagy-inducing condition used in <i>S. cerevisiae</i>. The mitophagy-deficient <i>atg32</i>Δ mutant of <i>C. glabrata</i> also exhibited decreased longevity under iron-deficient conditions. The mitochondrial membrane potential in <i>Cgatg32</i>Δ cells was significantly lower than that in wild-type cells under iron-depleted conditions. In a mouse model of disseminated infection, the <i>Cgatg32</i>Δ strain resulted in significantly decreased kidney and spleen fungal burdens compared with the wild-type strain. These results indicate that mitophagy in <i>C. glabrata</i> occurs in an iron-poor host tissue environment, and it may contribute to the longevity of cells, mitochondrial quality control, and pathogenesis.
DOI: 10.6084/m9.figshare.3464945.v1
title: Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeast <i>Candida glabrata</i>

description: <i>Candida glabrata</i>, a haploid budding yeast, is the cause of severe systemic infections in immune-compromised hosts. The amount of free iron supplied to <i>C. glabrata</i> cells during systemic infections is severely limited by iron-chelating proteins such as transferrin. Thus, the iron-deficiency response in <i>C. glabrata</i> cells is thought to play important roles in their survival inside the host's body. In this study, we found that mitophagy was induced under iron-depleted conditions, and that the disruption of a gene homologous to <i>ATG32</i>, which is responsible for mitophagy in <i>Saccharomyces cerevisiae</i>, blocked mitophagy in <i>C. glabrata</i>. The mitophagic activity in <i>C. glabrata</i> cells was not detected on short-period exposure to nitrogen-starved conditions, which is a mitophagy-inducing condition used in <i>S. cerevisiae</i>. The mitophagy-deficient <i>atg32</i>Δ mutant of <i>C. glabrata</i> also exhibited decreased longevity under iron-deficient conditions. The mitochondrial membrane potential in <i>Cgatg32</i>Δ cells was significantly lower than that in wild-type cells under iron-depleted conditions. In a mouse model of disseminated infection, the <i>Cgatg32</i>Δ strain resulted in significantly decreased kidney and spleen fungal burdens compared with the wild-type strain. These results indicate that mitophagy in <i>C. glabrata</i> occurs in an iron-poor host tissue environment, and it may contribute to the longevity of cells, mitochondrial quality control, and pathogenesis.
DOI: 10.6084/m9.figshare.3464918
title: The role of selected tree species in industrial sewage sludge/flotation tailing management

description: The aim of the study was to estimate the ability of ten tree and bush species to tolerate and accumulate Cd, Cu, Pb, Zn, and As species [As(III), As(V), and total organic arsenic] in industrial sewage sludge extremely contaminated with arsenic (almost 27.5 g kg<sup>−1</sup>) in a pot experiment. The premise being that it will then be possible to select the most promising tree/bush species, able to grow in the vicinity of dams where sewage sludge/flotation tailings are used as landfill. Six of the ten tested tree species were able to grow on the sludge. The highest content of total As was observed in <i>Betula pendula</i> roots (30.0 ± 1.3 mg kg<sup>−1</sup> DW), where the dominant As species was the toxic As(V). The highest biomass of Quercus Q1 robur (77.3 § 2.6 g) and Acer platanoides (76.0 § 4.9 g) was observed. A proper planting of selected tree species that are able to thrive on sewage sludge/flotation tailings could be an interesting and promising way to protect dams. By utilizing differences in their root systems and water needs, we will be able to reduce the risk of fatal environmental disasters.
DOI: 10.6084/m9.figshare.3464918.v2
title: The role of selected tree species in industrial sewage sludge/flotation tailing management

description: The aim of the study was to estimate the ability of ten tree and bush species to tolerate and accumulate Cd, Cu, Pb, Zn, and As species [As(III), As(V), and total organic arsenic] in industrial sewage sludge extremely contaminated with arsenic (almost 27.5 g kg<sup>−1</sup>) in a pot experiment. The premise being that it will then be possible to select the most promising tree/bush species, able to grow in the vicinity of dams where sewage sludge/flotation tailings are used as landfill. Six of the ten tested tree species were able to grow on the sludge. The highest content of total As was observed in <i>Betula pendula</i> roots (30.0 ± 1.3 mg kg<sup>−1</sup> DW), where the dominant As species was the toxic As(V). The highest biomass of Quercus Q1 robur (77.3 § 2.6 g) and Acer platanoides (76.0 § 4.9 g) was observed. A proper planting of selected tree species that are able to thrive on sewage sludge/flotation tailings could be an interesting and promising way to protect dams. By utilizing differences in their root systems and water needs, we will be able to reduce the risk of fatal environmental disasters.
DOI: 10.6084/m9.figshare.3464897
title: Oral diseases in a Chilean population (Talca)

description: Oral diseases in Chilean population. Study participants.
DOI: 10.6084/m9.figshare.3464897.v1
title: S1_ODs_Rivera_supplementary_information_1.xlsx

description: Oral diseases in Chilean population. Study participants.
DOI: 10.6084/m9.figshare.3464897.v2
title: Oral diseases in Chilean population. Study participants

description: Oral diseases in Chilean population. Study participants.
DOI: 10.6084/m9.figshare.3464897.v3
title: Oral diseases in a Chilean population (Talca). Study participants

description: Oral diseases in Chilean population. Study participants.
DOI: 10.6084/m9.figshare.3464897.v4
title: Oral diseases in a Chilean population (Talca)

description: Oral diseases in Chilean population. Study participants.
DOI: 10.6084/m9.figshare.3464897.v5
title: Oral diseases in a Chilean population (Talca)

description: Oral diseases in Chilean population. Study participants.
DOI: 10.6084/m9.figshare.3464831
title: Inconsistent selection of outcomes and measurement devices found in shoulder arthroplasty research: A systematic review

description: A ClinicalTrials.gov search was conducted and yielded 100 results. Articles meeting inclusion criteria were coded on the following characteristics: start date of trial, study status, study type, type of arthroplasty, sample size, measured outcomes, outcome measurement device, specific metric of measurement, method of aggregation, and outcome classification, and whether the outcome was considered a side effect/harmful.
DOI: 10.6084/m9.figshare.3464831.v2
title: Inconsistent selection of outcomes and measurement devices found in shoulder arthroplasty research: A systematic review

description: A ClinicalTrials.gov search was conducted and yielded 100 results. Articles meeting inclusion criteria were coded on the following characteristics: start date of trial, study status, study type, type of arthroplasty, sample size, measured outcomes, outcome measurement device, specific metric of measurement, method of aggregation, and outcome classification, and whether the outcome was considered a side effect/harmful.
DOI: 10.6084/m9.figshare.3464831.v1
title: New draft item

description: A ClinicalTrials.gov search was conducted and yielded 100 results. Articles meeting inclusion criteria were coded on the following characteristics: start date of trial, study status, study type, type of arthroplasty, sample size, measured outcomes, outcome measurement device, specific metric of measurement, method of aggregation, and outcome classification, and whether the outcome was considered a side effect/harmful.
DOI: 10.6084/m9.figshare.3464768
title: Progress and prospects in pharmacogenetics of antidepressant drugs

description: <b>Introduction</b>: Depression is responsible for the most part of the personal and socio-economic burden due to psychiatric disorders. Since antidepressant response clusters in families, pharmacogenetics represents a meaningful tool to provide tailored treatments and improve the prognosis of depression. <b>Areas covered</b>: This review aims to summarize and discuss the pharmacogenetics of antidepressant drugs in major depressive disorder, with a focus on the most replicated genes, genome-wide association studies (GWAS), but also on the findings provided by new and promising analysis methods. In particular, multimarker tests such as pathway analysis and polygenic risk scores increase the power of detecting associations compared to the analysis of individual polymorphisms. Since genetic variants are not necessarily associated with a change in protein level, gene expression studies may provide complementary information to genetic studies. Finally, the pharmacogenetic tests that have been investigated for clinical application are discussed. <b>Expert opinion</b>: Despite the lack of widespread clinical applications, preliminary results suggest that pharmacogenetics may be useful to guide antidepressant treatment. The US Food and Drug Administration included pharmacogenetic indications in the labeling of several antidepressants. This represented an important official recognition of the clinical relevance of genetic polymorphisms in antidepressant treatment.
DOI: 10.6084/m9.figshare.3464768.v1
title: Progress and prospects in pharmacogenetics of antidepressant drugs

description: <b>Introduction</b>: Depression is responsible for the most part of the personal and socio-economic burden due to psychiatric disorders. Since antidepressant response clusters in families, pharmacogenetics represents a meaningful tool to provide tailored treatments and improve the prognosis of depression. <b>Areas covered</b>: This review aims to summarize and discuss the pharmacogenetics of antidepressant drugs in major depressive disorder, with a focus on the most replicated genes, genome-wide association studies (GWAS), but also on the findings provided by new and promising analysis methods. In particular, multimarker tests such as pathway analysis and polygenic risk scores increase the power of detecting associations compared to the analysis of individual polymorphisms. Since genetic variants are not necessarily associated with a change in protein level, gene expression studies may provide complementary information to genetic studies. Finally, the pharmacogenetic tests that have been investigated for clinical application are discussed. <b>Expert opinion</b>: Despite the lack of widespread clinical applications, preliminary results suggest that pharmacogenetics may be useful to guide antidepressant treatment. The US Food and Drug Administration included pharmacogenetic indications in the labeling of several antidepressants. This represented an important official recognition of the clinical relevance of genetic polymorphisms in antidepressant treatment.
DOI: 10.6084/m9.figshare.3464759
title: Integrated Free-Form Results

description: The results from an integrated blade design for wind turbines.
DOI: 10.6084/m9.figshare.3464759.v2
title: Integrated Free-Form Results

description: The results from an integrated blade design for wind turbines.
DOI: 10.6084/m9.figshare.3464759.v1
title: Integrated Free-Form Results

description: The results from an integrated blade design for wind turbines.
DOI: 10.6084/m9.figshare.3464750
title: The Effect of K-Lactate Salt and Liquid Smoke on Bacterial Growth in a Model System

description: The effects of a commercial lactate salt formulation—containing potassium lactate (KL) and potassium acetate (KA)—and liquid smoke (LS) on the growth of selected lactic acid bacteria (LAB; <i>Carnobacterium maltaromaticum, Carnobacterium inhibens, Lactococcus lactis, Lactobacillus curvatus</i>, and <i>Enterococcus faecalis</i>), fish spoilage bacteria (<i>Photobacterium phosphoreum, Pseudomonas putida</i>, and <i>Vibrio vulnificus</i>), and <i>Listeria innocua</i>, were examined in a tryptic soy broth model system at 20ºC based on BioScreen data. The most pronounced inhibition effect on growth of bacteria was seen in the presence of 6% KL + 0.4% KA, used either combined with LS or alone. Only a minor inhibition effect on growth was found in the presence of LS alone. The only exception was <i>Lactobacillus curvatus</i>, which grew quite well in the presence of LS compared to control medium. The growth of <i>Vibrio vulnificus</i> was prevented in 6% KL + 0.4% KA, and significantly inhibited in the presence of 3% KL + 0.2% KA. When <i>V. vulnificus</i> was grown in NaCl, KA, and KL + KA, it was observed that KL + KA had a better inhibition effect than sodium salt within the same concentration range.