cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12472763
title: The impact of allergies and smoking status on nasal mucosa of hypertrophied turbinates – an immunohistologic analysis

description: <b>Background:</b> Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied. <b>Objectives:</b> To study the impact of smoking with relation to allergies on nasal mucosa histology and to characterize an immunologic profile using immunohistochemical (IHC) staining. <b>Methods:</b> A cross-sectional study. Nasal biopsies of inferior turbinates from smokers with different allergic statuses were compared. Demographics, comorbidities, histologic, and immunohistochemical (IHC) staining of CD3, CD68, CD 20, and CD138 receptors were compared and analyzed. <b>Results:</b> A total of 53 patients were included, of which 20 (37.7%) were smokers, and 20 (37.7%) had allergic backgrounds. Smokers, both allergic and non-allergic, demonstrated reduced edema compared to the control group (<i>p</i> Value = 0.034) and significantly lower eosinophil density in the stroma compared to the allergic nonsmokers’ group (<i>p</i> Value = 0.04). Smokers had a significant negative correlation between the number of cigarettes per day and the expression of CD20 in the stroma (−0.452, <i>p</i> Value = 0.045) and the epithelium (−0.432, <i>p</i> Value = 0.057) in IHC staining. Allergic smokers had a negative correlation (−0.705, <i>p</i> Value = 0.023) between the number of cigarettes per day and the CD68 marked cell expression in the epithelium. <b>Conclusion:</b> The coexistence of an allergic background and smoking alters known immunologic responses within the nasal mucosa. Smoking may have an immunosuppressive role in the nasal mucosa in both innate and humoral immune systems.
DOI: 10.6084/m9.figshare.12472763.v1
title: The impact of allergies and smoking status on nasal mucosa of hypertrophied turbinates – an immunohistologic analysis

description: <b>Background:</b> Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied. <b>Objectives:</b> To study the impact of smoking with relation to allergies on nasal mucosa histology and to characterize an immunologic profile using immunohistochemical (IHC) staining. <b>Methods:</b> A cross-sectional study. Nasal biopsies of inferior turbinates from smokers with different allergic statuses were compared. Demographics, comorbidities, histologic, and immunohistochemical (IHC) staining of CD3, CD68, CD 20, and CD138 receptors were compared and analyzed. <b>Results:</b> A total of 53 patients were included, of which 20 (37.7%) were smokers, and 20 (37.7%) had allergic backgrounds. Smokers, both allergic and non-allergic, demonstrated reduced edema compared to the control group (<i>p</i> Value = 0.034) and significantly lower eosinophil density in the stroma compared to the allergic nonsmokers’ group (<i>p</i> Value = 0.04). Smokers had a significant negative correlation between the number of cigarettes per day and the expression of CD20 in the stroma (−0.452, <i>p</i> Value = 0.045) and the epithelium (−0.432, <i>p</i> Value = 0.057) in IHC staining. Allergic smokers had a negative correlation (−0.705, <i>p</i> Value = 0.023) between the number of cigarettes per day and the CD68 marked cell expression in the epithelium. <b>Conclusion:</b> The coexistence of an allergic background and smoking alters known immunologic responses within the nasal mucosa. Smoking may have an immunosuppressive role in the nasal mucosa in both innate and humoral immune systems.
DOI: 10.6084/m9.figshare.12472631
title: Fig3

description: Files of figure 3 with data, statistics and graphs.
DOI: 10.6084/m9.figshare.12472604
title: Fig2

description: Files of figure 2 with data, statistics and graphs.
DOI: 10.6084/m9.figshare.12472631.v1
title: Fig3

description: Files of figure 3 with data, statistics and graphs.
DOI: 10.6084/m9.figshare.12472604.v1
title: Fig2

description: Files of figure 2 with data, statistics and graphs.
DOI: 10.6084/m9.figshare.12472526
title: Feature vs Barcode matrices (Kallisto, CellRanger, CITE-seq-count) from GEX, ADT and HTO modalities

description: Feature vs Barcode matrices from mRNA (GEX), antibody-derived tags (ADT) and hashtag oligos (HTO).<br>Unfiltered matrices to allow replication of the analysis of signal from cell-containing versus non-cell-containing droplets.<br>ADT and HTO was aligned with four pipelines:Kallisto-Bustools-KITECellRanger FeatureOnlyCITE-seq-count (default UMI correction)CITE-seq-count (No UMI correction)<br>
DOI: 10.6084/m9.figshare.12472352
title: Plasma angiogenesis and oxidative stress markers in patients with diabetic retinopathy

description: <b>Background:</b> Neovascularization in the retina and hyperglycaemia-induced oxidative stress are implicated in the pathogenesis of diabetic retinopathy (DR). In this study, we hypothesized that the plasma angiogenic and oxidative stress markers associated with these derangements could aid in the screening of diabetic patients who are at an increased risk of developing retinopathy. <b>Methods:</b> This study included normal (<i>n</i> = 148), type2 diabetes without retinopathy (DNR; <i>n</i> = 148), proliferative DR (PDR; <i>n</i> = 74) and non-PDR (NPDR; <i>n</i> = 148) subjects. Plasma concentrations of vascular endothelial growth factor-A (VEGF-A), hypoxia-inducible factor-1α (HIF-1α), matrix metalloproteinase-9 (MMP-9), pigment epithelium-derived factor (PEDF), nitric oxide (NO), soluble receptors for advanced glycation end products (sRAGE), malondialdehyde (MDA) and protein thiols were estimated. <b>Results:</b> A statistically significant increase was observed in the plasma concentrations of pro-angiogenic factors and markers of oxidative stress in both retinopathy groups. By contrast, the concentrations of anti-angiogenic factors and antioxidants were decreased significantly in these groups. Receiver operating characteristic analysis indicated that the plasma thresholds of HIF-1α and PEDF can be suitable markers in case of NPDR. However, in PDR, HIF-1α, NO, MMP-9 and PEDF showed high sensitivity and specificity. <b>Conclusions:</b> The factors associated with hypoxia, matrix degradation and angiogenic inhibition play a crucial role in predicting DR.
DOI: 10.6084/m9.figshare.12472235
title: 5P-CITE-seq_Titration.rds

description: Seurat V3 object with all conditions downsampled to similar numbers within clusters from each tissue.<br>The code used to generate this file can be found at GitHub: https://github.com/Terkild/CITE-seq_optimization<br>
DOI: 10.6084/m9.figshare.12472238
title: 5P-CITE-seq_Titration_full.rds

description: Seurat V3 object with all conditions without downsampling.<br>The code used to generate this file can be found at GitHub: https://github.com/Terkild/CITE-seq_optimization
DOI: 10.6084/m9.figshare.12472352.v1
title: Plasma angiogenesis and oxidative stress markers in patients with diabetic retinopathy

description: <b>Background:</b> Neovascularization in the retina and hyperglycaemia-induced oxidative stress are implicated in the pathogenesis of diabetic retinopathy (DR). In this study, we hypothesized that the plasma angiogenic and oxidative stress markers associated with these derangements could aid in the screening of diabetic patients who are at an increased risk of developing retinopathy. <b>Methods:</b> This study included normal (<i>n</i> = 148), type2 diabetes without retinopathy (DNR; <i>n</i> = 148), proliferative DR (PDR; <i>n</i> = 74) and non-PDR (NPDR; <i>n</i> = 148) subjects. Plasma concentrations of vascular endothelial growth factor-A (VEGF-A), hypoxia-inducible factor-1α (HIF-1α), matrix metalloproteinase-9 (MMP-9), pigment epithelium-derived factor (PEDF), nitric oxide (NO), soluble receptors for advanced glycation end products (sRAGE), malondialdehyde (MDA) and protein thiols were estimated. <b>Results:</b> A statistically significant increase was observed in the plasma concentrations of pro-angiogenic factors and markers of oxidative stress in both retinopathy groups. By contrast, the concentrations of anti-angiogenic factors and antioxidants were decreased significantly in these groups. Receiver operating characteristic analysis indicated that the plasma thresholds of HIF-1α and PEDF can be suitable markers in case of NPDR. However, in PDR, HIF-1α, NO, MMP-9 and PEDF showed high sensitivity and specificity. <b>Conclusions:</b> The factors associated with hypoxia, matrix degradation and angiogenic inhibition play a crucial role in predicting DR.
DOI: 10.6084/m9.figshare.12472205
title: Supplementary Material for: Umsetzbarkeit und Erleben: Erste Erfahrungen mit einer Kurzform der anwendungsorientierten Parcoursprüfung im MSc-Studiengang Psychologie

description: <b><i>Einleitung:</i></b> Voraussetzung für die Approbation im Rahmen der neuen Psychotherapeutenausbildung ist u.a. das Bestehen einer anwendungsorientierten Parcoursprüfung. Da diese Prüfung von Lehrenden und Studierenden als Herausforderung angesehen wird, wurde eine Kurzform der Parcoursprüfung im Rahmen einer Modulprüfung des MSc-Studiengangs Psychologie eingeführt und evaluiert. <b><i>Methode:</i></b> Für die 15-minütige Parcoursprüfung wurden 9 Kompe­tenzbereiche basierend auf praxisorientierten Psychotherapieseminaren entwickelt, von denen 2 jeweils geprüft wurden. Zur Standardisierung der Benotung wurde ein Bewertungsbogen konzipiert. Eine Mitarbeiterin erhielt ein Training als Simulationspatientin. Für die Evaluation wurde ein Fragebogen entwickelt, welcher u.a. die Umsetzbarkeit und das subjektive Erleben dieses Prüfungsformats aus der Sicht der an der Prüfung beteiligten Personen erfasst. <b><i>Ergebnisse:</i></b> 14 Prüfungskandidierende ließen sich durch 3 Prüfende prüfen. Die Gesamtdurchschnittsnote betrug 1,19 (Bereich: 1,0–2,3). Die Auswertung der Fragebögen zeigte, dass alle drei Gruppen die Prüfung als geeignet, die praktischen Fertigkeiten abzubilden, objektiv und praxisnah empfanden. Von den Prüfungskandidierenden gaben 50% an, dass die Prüfung sie gestresst habe, während die Simulationspatientin sich nie und die Prüfenden sich gar nicht (78%) oder kaum (22%) gestresst fühlten. <b><i>Diskussion:</i></b> Die Ergebnisse dieser Pilotstudie weisen auf eine gute Umsetzbarkeit der Parcoursprüfung hin, wenngleich sie auch mit Stress für die Prüfungskandidierenden verbunden war. Die Pilotstudie wird limitiert durch eine kleine und wahrscheinlich verzerrte Stichprobe (motivierte Studierende) ohne Vergleichsgruppe. Abschließend werden die Vor- und Nachteile dieses Prüfungsmodells kritisch diskutiert.
DOI: 10.6084/m9.figshare.12472238.v1
title: 5P-CITE-seq_Titration_full.rds

description: Seurat V3 object with all conditions without downsampling.<br>The code used to generate this file can be found at GitHub: https://github.com/Terkild/CITE-seq_optimization
DOI: 10.6084/m9.figshare.12472151
title: erl_revision

description: The following files support the new emissions calculations added into the paper which this cites.area.mat gives the geospatial location of each emissions region.emissions_weekly_ts.mat provides the time series of the emissions using the pseudo mass approach.scale_emissions.mat provides the time series of the emissions using the correlation/overlap approach.eemission2_3.mat comprises statistics of the emissions.gfedco_time_series.mat provides the time series of CO.wind_div.mat is the calculated wind divergence.
DOI: 10.6084/m9.figshare.12472205.v1
title: Supplementary Material for: Umsetzbarkeit und Erleben: Erste Erfahrungen mit einer Kurzform der anwendungsorientierten Parcoursprüfung im MSc-Studiengang Psychologie

description: <b><i>Einleitung:</i></b> Voraussetzung für die Approbation im Rahmen der neuen Psychotherapeutenausbildung ist u.a. das Bestehen einer anwendungsorientierten Parcoursprüfung. Da diese Prüfung von Lehrenden und Studierenden als Herausforderung angesehen wird, wurde eine Kurzform der Parcoursprüfung im Rahmen einer Modulprüfung des MSc-Studiengangs Psychologie eingeführt und evaluiert. <b><i>Methode:</i></b> Für die 15-minütige Parcoursprüfung wurden 9 Kompe­tenzbereiche basierend auf praxisorientierten Psychotherapieseminaren entwickelt, von denen 2 jeweils geprüft wurden. Zur Standardisierung der Benotung wurde ein Bewertungsbogen konzipiert. Eine Mitarbeiterin erhielt ein Training als Simulationspatientin. Für die Evaluation wurde ein Fragebogen entwickelt, welcher u.a. die Umsetzbarkeit und das subjektive Erleben dieses Prüfungsformats aus der Sicht der an der Prüfung beteiligten Personen erfasst. <b><i>Ergebnisse:</i></b> 14 Prüfungskandidierende ließen sich durch 3 Prüfende prüfen. Die Gesamtdurchschnittsnote betrug 1,19 (Bereich: 1,0–2,3). Die Auswertung der Fragebögen zeigte, dass alle drei Gruppen die Prüfung als geeignet, die praktischen Fertigkeiten abzubilden, objektiv und praxisnah empfanden. Von den Prüfungskandidierenden gaben 50% an, dass die Prüfung sie gestresst habe, während die Simulationspatientin sich nie und die Prüfenden sich gar nicht (78%) oder kaum (22%) gestresst fühlten. <b><i>Diskussion:</i></b> Die Ergebnisse dieser Pilotstudie weisen auf eine gute Umsetzbarkeit der Parcoursprüfung hin, wenngleich sie auch mit Stress für die Prüfungskandidierenden verbunden war. Die Pilotstudie wird limitiert durch eine kleine und wahrscheinlich verzerrte Stichprobe (motivierte Studierende) ohne Vergleichsgruppe. Abschließend werden die Vor- und Nachteile dieses Prüfungsmodells kritisch diskutiert.
DOI: 10.6084/m9.figshare.12472151.v1
title: erl_revision

description: The following files support the new emissions calculations added into the paper which this cites.area.mat gives the geospatial location of each emissions region.emissions_weekly_ts.mat provides the time series of the emissions using the pseudo mass approach.scale_emissions.mat provides the time series of the emissions using the correlation/overlap approach.eemission2_3.mat comprises statistics of the emissions.gfedco_time_series.mat provides the time series of CO.wind_div.mat is the calculated wind divergence.
DOI: 10.6084/m9.figshare.12472070
title: Metadata record for: CerebrA, registration and manual label correction of the Mindboggle-101 atlas for the MNI-ICBM152 template

description: This dataset contains key characteristics about the data described in the Data Descriptor CerebrA, registration and manual label correction of the Mindboggle-101 atlas for the MNI-ICBM152 template. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.12472070.v1
title: Metadata record for: CerebrA, registration and manual label correction of the Mindboggle-101 atlas for the MNI-ICBM152 template

description: This dataset contains key characteristics about the data described in the Data Descriptor CerebrA, registration and manual label correction of the Mindboggle-101 atlas for the MNI-ICBM152 template. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.12472016
title: Dataset for manuscript "Alkynyl-functionalized chain-extended PCL for coupling to biological molecules"

description: Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany<br>Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany<br><br>The dataset includes raw and processed data for the manuscript “Alkynyl-functionalized chain-extended PCL for coupling to biological molecules”, DOI: 10.1016/j.eurpolymj.2020.109908<br><br>Sample IDs:<br>2: PH-14-053<br>3: PH-14-060<br>4a: MZ-14-021<br>4b: MZ-15-001<br>4c: MZ-15-012<br>4d: MZ-15-003<br>4e: MZ-14-024<br>4f: MZ-15-006<br>4g: MZ-15-015<br>4h: MZ-15-007<br>Table 2 #1: PH-14-090<br>Table 2 #2: PH-14-092<br>Table 2 #3: PH-15-010<br>Table 2 #4: PH-15-005<br>Table 2 #5: PH-15-006<br>Table 2 #6: PH-15-007<br>Table 2 #7: PH-15-022<br>Table 2 #8: PH-15-015<br>Table 2 #9: PH-15-025<br>6: PH-14-084<br>7: PH-14-087<br>8: PH-15-017<br>9a: PH-15-027<br>9e: PH-15-029<br><br><br>
DOI: 10.6084/m9.figshare.12471806
title: Supplementary Material for: Sleep-Disordered Breathing in Children with Prader-Willi Syndrome in Relation to Growth Hormone Therapy Onset

description: <b><i>Objective:</i></b> The aim of this study was to consider sleep apnea in Prader-Willi syndrome (PWS) children depending on age at growth hormone (GH) therapy onset. <b><i>Study Design:</i></b> We analyzed longitudinally cardiorespiratory polygraphy of 62 PWS children (aged 0–2.5 years at baseline). Twenty-one children (Group A) started GH-therapy during and 41 children (Group B) after their first year of life. Data were acquired before, at 3 and 6 months, then 1.2, 2.2, and 3.2 years after GH onset. Outcomes were determined with the obstructive apnea hypopnea index (OAHI), central apnea index (CAI), oxygen desaturation index (ODI), and by measuring obstructive sleep apnea (OSA) and peripheral blood oxygen saturation (SpO<sub>2</sub>). <b><i>Results:</i></b> We observed no significant differences in OAHI, CAI, ODI, and SpO<sub>2</sub> depending on treatment onset. At baseline, 5/21 patients (23.8%) in Group A versus 15/41 patients (36.6%) in Group B showed pathological sleep apnea (OAHI ≥1.5). Pathological OSA increased significantly in Group A during the first 3 months of therapy but dropped below baseline after 1 year in both groups. ODI changed during GH therapy in both groups (from 4.0 to 2.6 in Group A, and 3.6 to 1.6 in Group B; baseline to 3.2 years; <i>p</i> &lt; 0.05). <b><i>Conclusions:</i></b> OSA in PWS children appears to develop independently of treatment onset. Treatment may therefore safely be initiated early but should be accompanied by regular sleep analysis.
DOI: 10.6084/m9.figshare.12472016.v1
title: Dataset for manuscript "Alkynyl-functionalized chain-extended PCL for coupling to biological molecules"

description: Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany<br>Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany<br><br>The dataset includes raw and processed data for the manuscript “Alkynyl-functionalized chain-extended PCL for coupling to biological molecules”, DOI: 10.1016/j.eurpolymj.2020.109908<br><br>Sample IDs:<br>2: PH-14-053<br>3: PH-14-060<br>4a: MZ-14-021<br>4b: MZ-15-001<br>4c: MZ-15-012<br>4d: MZ-15-003<br>4e: MZ-14-024<br>4f: MZ-15-006<br>4g: MZ-15-015<br>4h: MZ-15-007<br>Table 2 #1: PH-14-090<br>Table 2 #2: PH-14-092<br>Table 2 #3: PH-15-010<br>Table 2 #4: PH-15-005<br>Table 2 #5: PH-15-006<br>Table 2 #6: PH-15-007<br>Table 2 #7: PH-15-022<br>Table 2 #8: PH-15-015<br>Table 2 #9: PH-15-025<br>6: PH-14-084<br>7: PH-14-087<br>8: PH-15-017<br>9a: PH-15-027<br>9e: PH-15-029<br><br><br>
DOI: 10.6084/m9.figshare.12471977
title: Supplementary Material for: Severe Leukoaraiosis Is Associated with Poor Outcome after Successful Recanalization of M1 Middle Cerebral Artery Occlusion Strokes

description: <b><i>Background:</i></b> Severe leukoaraiosis (LA) is an established risk factor for poor outcome after mechanical thrombectomy (MT) for large vessel occlusion stroke. There is uncertainty whether this association also applies to successfully recanalized patients with M1 segment middle cerebral artery (MCA) occlusions. <b><i>Methods:</i></b> A retrospective single-centre study of patients with successful reperfusion (thrombolysis in cerebral infarction, TICI 2b or 3) after MT for an M1 MCA occlusion was performed over a 7-year period. LA score (LAS) was assessed using the age-related white matter change scale on pre-interventional brain imaging. <b><i>Results:</i></b> A total of 209 patients (median age 75.0 years) were included. LAS was assessed on pre-interventional imaging by computed tomography in 177 (84.7%) patients and magnetic resonance imaging in 32 (15.3%) patients. The median LAS was 1 (IQR 0–8), and severe LA consisted of the top 25 percentile, ranging from 9 to 24. Multivariable analysis demonstrated an association of severe LA (OR 0.32, 95% CI 0.12–0.88, <i>p</i> = 0.023), higher NIHSS on admission (OR 0.89, 95% CI 0.84–0.94, <i>p</i> &lt; 0.001), advanced age (OR 0.97, 95% CI 0.95–1.00, <i>p</i> = 0.039), good leptomeningeal collaterals (OR 3.65, 95% CI 1.46–8.15, <i>p</i> = 0.001), and TICI 3 score (OR 3.26, 95% CI 10.52–7.01) with good clinical outcome after 3 months as measured with the modified Rankin scale. <b><i>Conclusion:</i></b> Severe LA is associated with poor clinical outcome at 3 months in acute stroke patients undergoing MT due to emergent M1 MCA occlusion.
DOI: 10.6084/m9.figshare.12471806.v1
title: Supplementary Material for: Sleep-Disordered Breathing in Children with Prader-Willi Syndrome in Relation to Growth Hormone Therapy Onset

description: <b><i>Objective:</i></b> The aim of this study was to consider sleep apnea in Prader-Willi syndrome (PWS) children depending on age at growth hormone (GH) therapy onset. <b><i>Study Design:</i></b> We analyzed longitudinally cardiorespiratory polygraphy of 62 PWS children (aged 0–2.5 years at baseline). Twenty-one children (Group A) started GH-therapy during and 41 children (Group B) after their first year of life. Data were acquired before, at 3 and 6 months, then 1.2, 2.2, and 3.2 years after GH onset. Outcomes were determined with the obstructive apnea hypopnea index (OAHI), central apnea index (CAI), oxygen desaturation index (ODI), and by measuring obstructive sleep apnea (OSA) and peripheral blood oxygen saturation (SpO<sub>2</sub>). <b><i>Results:</i></b> We observed no significant differences in OAHI, CAI, ODI, and SpO<sub>2</sub> depending on treatment onset. At baseline, 5/21 patients (23.8%) in Group A versus 15/41 patients (36.6%) in Group B showed pathological sleep apnea (OAHI ≥1.5). Pathological OSA increased significantly in Group A during the first 3 months of therapy but dropped below baseline after 1 year in both groups. ODI changed during GH therapy in both groups (from 4.0 to 2.6 in Group A, and 3.6 to 1.6 in Group B; baseline to 3.2 years; <i>p</i> &lt; 0.05). <b><i>Conclusions:</i></b> OSA in PWS children appears to develop independently of treatment onset. Treatment may therefore safely be initiated early but should be accompanied by regular sleep analysis.