cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4884458
title: Supplementary Material for: Thiazide-Associated Hyponatremia, Report of the Hyponatremia Registry: An Observational Multicenter International Study

description: <b><i>Background:</i></b> Hyponatremia is a frequent and potentially life-threatening adverse side effect of thiazide diuretics. This sub-analysis of the Hyponatremia Registry database focuses on current management practices of thiazide-associated hyponatremia (TAH) and compares differences between TAH and syndrome of inappropriate antidiuretic hormone secretion (SIADH). <b><i>Methods:</i></b> We analyzed 477 patients from 225 US and EU sites with euvolemic hyponatremia ([Na<sup>+</sup>] ≤130 mEq/L) who were receiving a thiazide diuretic. Of these, 118 met criteria for true thiazide-induced hyponatremia (TIH). <b><i>Results:</i></b> Thiazide was withdrawn immediately after hyponatremia was diagnosed only in 57% of TAH; in these patients, the median rate of [Na<sup>+</sup>] change (Δ<sub>daily</sub>[Na<sup>+</sup>]) was significantly higher than those with continued thiazide treatment (3.8 [interquartile range: 4.0] vs. 1.7 [3.8] mEq/L/day). The most frequently employed therapies were isotonic saline (29.6%), fluid restriction (19.9%), the combination of these two (8.2%), and hypertonic saline (5.2%). Hypertonic saline produced the greatest Δ<sub>daily</sub>[Na<sup>+</sup>] (8.0[6.4] mEq/L/day) followed by a combination of fluid restriction and normal saline (4.5 [3.8] mEq/L/day) and normal saline alone (3.6 [3.5] mEq/L/day). Fluid restriction was markedly less effective (2.7 [2.7] mEq/L/day). Overly rapid correction of hyponatremia occurred in 3.1% overall, but in up to 21.4% given hypertonic saline. Although there are highly significant differences in the biochemical profiles between TIH and SIADH, no predictive diagnostic test could be derived. <b><i>Conclusions:</i></b> Despite its high incidence and potential risks, the management of TAH is often poor. Immediate withdrawal of the thiazide is crucial for treatment success. Hypertonic saline is most effective in correcting hyponatremia but associated with a high rate of overly rapid correction. We could not establish a diagnostic laboratory-based test to differentiate TIH from SIADH.
DOI: 10.6084/m9.figshare.4884404
title: Capture histories of juvenile and adult Silvereyes, Heron Island, Australia 1979-1994

description: Capture histories of juvenile and adult individuals for survival analysis, including age at first capture, environmental covariates and a README file explaining columns.<br>A separate spreadsheet with data used for nestling survival analysis is also provided.
DOI: 10.6084/m9.figshare.4884410
title: Predicted genes of Colletotrichum truncatum in gff and fasta formats

description: The list and amino acid sequence of C. truncatum genes predicted by MAKER2 based on consensus from RNA-Seq evidence, homology to other Colletotrichum species and SwissProt database, and ab initio gene prediction tools is provided in gff and fasta formats.<br>
DOI: 10.6084/m9.figshare.4884404.v1
title: Capture histories of juvenile and adult Silvereyes, Heron Island, Australia 1979-1994

description: Capture histories of juvenile and adult individuals for survival analysis, including age at first capture, environmental covariates and a README file explaining columns.<br>A separate spreadsheet with data used for nestling survival analysis is also provided.
DOI: 10.6084/m9.figshare.4884401
title: Nutrient export during storm events

description: Supporting datasets for:<br>"High-frequency monitoring of catchment nutrient exports reveals highly variable storm-event responses and dynamic source zone activation"<br>by P.J. Blaen et al. published in <i>JGR: Biogeosciences</i> (2017)
DOI: 10.6084/m9.figshare.4884410.v1
title: Predicted genes of Colletotrichum truncatum in gff and fasta formats

description: The list and amino acid sequence of C. truncatum genes predicted by MAKER2 based on consensus from RNA-Seq evidence, homology to other Colletotrichum species and SwissProt database, and ab initio gene prediction tools is provided in gff and fasta formats.<br>
DOI: 10.6084/m9.figshare.4884401.v1
title: Nutrient export during storm events

description: Supporting datasets for:<br>"High-frequency monitoring of catchment nutrient exports reveals highly variable storm-event responses and dynamic source zone activation"<br>by P.J. Blaen et al. published in <i>JGR: Biogeosciences</i> (2017)
DOI: 10.6084/m9.figshare.4884320
title: ESM data file from Does oxidative stress shorten telomeres?

description: This file contains the data used in our paper
DOI: 10.6084/m9.figshare.4884290
title: Gene Expression Atlas of Schistosoma mansoni - Part II

description: This is the second part (part II of two) of the data set obtained from the RNA-Seq analysis of transcriptomes of adult <i>Schistosoma mansoni </i>and their gonads. All genes represented by transcripts identified in the analysis were given by their Smp numbers. In addition to the average transcript amounts (Reads per Kilobase Million (RPKM), Y-axis) and occurrence, log<sub>2</sub> ratios were given as well as adjusted <i>P</i> values of pairing-, gender,- and tissue-related expression patterns. Custom codes to generate the data are given in a separate file.<br>Abbreviations used for the bar plots (X-axis) are:<br>bM (bisex males), paired males; sM (single-sex males), unpaired males; bF (bisex females), paired females; sF (single-sex females), unpaired females; bT, testis of bM; sT, testis of sM; bO, ovary of bM; sO, ovary of sO. <br>
DOI: 10.6084/m9.figshare.4884320.v1
title: ESM data file from Does oxidative stress shorten telomeres?

description: This file contains the data used in our paper
DOI: 10.6084/m9.figshare.4884290.v1
title: Gene Expression Atlas of Schistosoma mansoni - Part II

description: This is the second part (part II of two) of the data set obtained from the RNA-Seq analysis of transcriptomes of adult <i>Schistosoma mansoni </i>and their gonads. All genes represented by transcripts identified in the analysis were given by their Smp numbers. In addition to the avrage transcript amounts (Reads per Kilobase Million (RPKM), Y-axis) and occurrence, log<sub>2</sub> ratios were given as well as adjusted <i>P</i> values of pairing-, gender,- and tissue-related expression patterns. <br>Abbreviations used for the bar plots (X-axis) are:<br>bM (bisex males), paired males; sM (single-sex males), unpaired males; bF (bisex females), paired females; sF (single-sex females), unpaired females; bT, testis of bM; sT, testis of sM; bO, ovary of bM; sO, ovary of sO. <br>
DOI: 10.6084/m9.figshare.4884248
title: Thermoalkalophilic lipase from an extremely halophilic bacterial strain <i>Bacillus atrophaeus</i> FSHM2: Purification, biochemical characterization and application

description: The present study was designed to isolate and identify an extremely halophilic lipase-producing bacterial strain, purify and characterize the related enzyme and evaluate its application for ethyl and methyl valerate synthesis. Among four halophilic isolates, the lipolytic ability of one isolate (identified as <i>Bacillus atrophaeus</i> FSHM2) was confirmed. The enzyme (designated as <i>Ba</i>L) was purified using three sequential steps of ethanol precipitation and dialysis, Q-Sepharose XL anion-exchange chromatography and SP Sepharose cation-exchange chromatography with a final yield of 9.9% and a purification factor of 31.8. The purified <i>Ba</i>L (Mw∼85 kDa) was most active at 70 °C and pH 9 in the presence of 4 M NaCl and retained 58.7% of its initial activity after 150 min of incubation at 80 °C. The enzyme was inhibited by Cd<sup>2+</sup> (35.6 ± 1.7%) but activated by Ca<sup>2+</sup> (132.4 ± 2.2%). Evaluation of <i>Ba</i>L's stability in the presence of organic solvents showed that xylene (25%) enhanced the relative activity of the enzyme to 334.2 ± 0.6% after 1 h of incubation. The results of esterification studies using the purified <i>Ba</i>L revealed that maximum ethyl valerate (88.5%) and methyl valerate (67.5%) synthesis occurred in the organic solvent medium (xylene) after 48 h of incubation at 50 °C.
DOI: 10.6084/m9.figshare.4884245
title: Electric field-navigated transcranial magnetic stimulation for chronic tinnitus: a randomized, placebo-controlled study

description: <i>Objective</i>: Repetitive transcranial magnetic stimulation (rTMS) may alleviate tinnitus. We evaluated effects of electric field (E-field) navigated rTMS targeted according to tinnitus pitch. No controlled studies have investigated anatomically accurate E-field-rTMS for tinnitus. <i>Design</i>: Effects of E-field-rTMS were evaluated in a prospective randomised placebo-controlled 6-month follow-up study on parallel groups. Patients received 10 sessions of 1 Hz rTMS or placebo targeted to the left auditory cortex corresponding to tonotopic representation of tinnitus pitch. Effects were evaluated immediately after treatment and at 1, 3 and 6 months. Primary outcome measures were visual analogue scores (VAS 0–100) for tinnitus intensity, annoyance and distress, and the Tinnitus Handicap Inventory (THI). <i>Study sample:</i> Thirty-nine patients (mean age 50.3 years). <i>Results</i>: The mean tinnitus intensity (<i>F</i><sub>3</sub> = 15.7, <i>p</i> F<sub>3</sub> = 8.8, <i>p</i> = 0.0002), distress (<i>F</i><sub>3</sub> = 9.1, <i>p</i> = 0.0002) and THI scores (<i>F</i><sub>4</sub> = 13.8, <i>p</i> p = 0.082 and <i>p</i> = 0.065). <i>Conclusions</i>: Despite the significant effects of rTMS on tinnitus, differences between active and placebo groups remained non-significant, due to large placebo-effect and wide inter-individual variation.
DOI: 10.6084/m9.figshare.4884248.v1
title: Thermoalkalophilic lipase from an extremely halophilic bacterial strain <i>Bacillus atrophaeus</i> FSHM2: Purification, biochemical characterization and application

description: The present study was designed to isolate and identify an extremely halophilic lipase-producing bacterial strain, purify and characterize the related enzyme and evaluate its application for ethyl and methyl valerate synthesis. Among four halophilic isolates, the lipolytic ability of one isolate (identified as <i>Bacillus atrophaeus</i> FSHM2) was confirmed. The enzyme (designated as <i>Ba</i>L) was purified using three sequential steps of ethanol precipitation and dialysis, Q-Sepharose XL anion-exchange chromatography and SP Sepharose cation-exchange chromatography with a final yield of 9.9% and a purification factor of 31.8. The purified <i>Ba</i>L (Mw∼85 kDa) was most active at 70 °C and pH 9 in the presence of 4 M NaCl and retained 58.7% of its initial activity after 150 min of incubation at 80 °C. The enzyme was inhibited by Cd<sup>2+</sup> (35.6 ± 1.7%) but activated by Ca<sup>2+</sup> (132.4 ± 2.2%). Evaluation of <i>Ba</i>L's stability in the presence of organic solvents showed that xylene (25%) enhanced the relative activity of the enzyme to 334.2 ± 0.6% after 1 h of incubation. The results of esterification studies using the purified <i>Ba</i>L revealed that maximum ethyl valerate (88.5%) and methyl valerate (67.5%) synthesis occurred in the organic solvent medium (xylene) after 48 h of incubation at 50 °C.
DOI: 10.6084/m9.figshare.4884239
title: Effects of direct renin inhibition versus angiotensin II receptor blockade on angiotensin profiles in non-diabetic chronic kidney disease

description: <b>Background:</b> Direct renin inhibition (DRI) is clinically inferior to other blockers of the renin–angiotensin system (RAS). Thus far, the underlying molecular causes of this finding remain unknown. <b>Methods:</b> Twenty four patients with non-diabetic chronic kidney disease (CKD) stages III–IV and albuminuria were randomized to DRI or angiotensin receptor blocker (ARB). Employing a novel mass-spectrometry method, the concentrations of renin, aldosterone and plasma angiotensin peptides [Ang I, Ang II, Ang-(1-7), Ang-(1-5), Ang-(2-8), Ang-(3-8)] were quantified before and after an 8-week treatment. <b>Results:</b> While blood pressure, renal function and albuminuria decreased comparably in both groups, profound RAS component differences were observed: DRI led to a massive renin increase, while suppressing both vasoconstrictive (Ang I and Ang II) and vasodilatory RAS metabolites (Ang-(1-7) and Ang-(1-5)). In contrast, ARB led to a four-fold increase of Ang I and Ang II, while Ang-(1-7) and Ang-(1-5) increased moderately but significantly. With ARB treatment, a decreased aldosterone-to-Ang II ratio suggested efficacy in blocking AT1 receptor. <b>Conclusions:</b> DRI therapy abolishes all RAS effector peptides. ARB increases both vasoconstrictive and vasodilative angiotensins, while this is accompanied by efficient blockade of vasoconstrictive effects. These differential molecular regulations should be considered when selecting optimal antihypertensive and disease-modifying therapy in CKD patients.Key messagesDirect renin inhibition leads to a complete and lasting abolition of both classical and alternative RAS components.Angiotensin receptor blockade leads to effective receptor blockade and up-regulation of alternative RAS components.Differential molecular regulations of the RAS should be considered when selecting optimal antihypertensive and disease-modifying therapy in CKD patients. Direct renin inhibition leads to a complete and lasting abolition of both classical and alternative RAS components. Angiotensin receptor blockade leads to effective receptor blockade and up-regulation of alternative RAS components. Differential molecular regulations of the RAS should be considered when selecting optimal antihypertensive and disease-modifying therapy in CKD patients.
DOI: 10.6084/m9.figshare.4884239.v1
title: Effects of direct renin inhibition versus angiotensin II receptor blockade on angiotensin profiles in non-diabetic chronic kidney disease

description: <b>Background:</b> Direct renin inhibition (DRI) is clinically inferior to other blockers of the renin–angiotensin system (RAS). Thus far, the underlying molecular causes of this finding remain unknown. <b>Methods:</b> Twenty four patients with non-diabetic chronic kidney disease (CKD) stages III–IV and albuminuria were randomized to DRI or angiotensin receptor blocker (ARB). Employing a novel mass-spectrometry method, the concentrations of renin, aldosterone and plasma angiotensin peptides [Ang I, Ang II, Ang-(1-7), Ang-(1-5), Ang-(2-8), Ang-(3-8)] were quantified before and after an 8-week treatment. <b>Results:</b> While blood pressure, renal function and albuminuria decreased comparably in both groups, profound RAS component differences were observed: DRI led to a massive renin increase, while suppressing both vasoconstrictive (Ang I and Ang II) and vasodilatory RAS metabolites (Ang-(1-7) and Ang-(1-5)). In contrast, ARB led to a four-fold increase of Ang I and Ang II, while Ang-(1-7) and Ang-(1-5) increased moderately but significantly. With ARB treatment, a decreased aldosterone-to-Ang II ratio suggested efficacy in blocking AT1 receptor. <b>Conclusions:</b> DRI therapy abolishes all RAS effector peptides. ARB increases both vasoconstrictive and vasodilative angiotensins, while this is accompanied by efficient blockade of vasoconstrictive effects. These differential molecular regulations should be considered when selecting optimal antihypertensive and disease-modifying therapy in CKD patients.Key messagesDirect renin inhibition leads to a complete and lasting abolition of both classical and alternative RAS components.Angiotensin receptor blockade leads to effective receptor blockade and up-regulation of alternative RAS components.Differential molecular regulations of the RAS should be considered when selecting optimal antihypertensive and disease-modifying therapy in CKD patients. Direct renin inhibition leads to a complete and lasting abolition of both classical and alternative RAS components. Angiotensin receptor blockade leads to effective receptor blockade and up-regulation of alternative RAS components. Differential molecular regulations of the RAS should be considered when selecting optimal antihypertensive and disease-modifying therapy in CKD patients.
DOI: 10.6084/m9.figshare.4884245.v3
title: Electric field-navigated transcranial magnetic stimulation for chronic tinnitus: a randomized, placebo-controlled study

description: <i>Objective</i>: Repetitive transcranial magnetic stimulation (rTMS) may alleviate tinnitus. We evaluated effects of electric field (E-field) navigated rTMS targeted according to tinnitus pitch. No controlled studies have investigated anatomically accurate E-field-rTMS for tinnitus. <i>Design</i>: Effects of E-field-rTMS were evaluated in a prospective randomised placebo-controlled 6-month follow-up study on parallel groups. Patients received 10 sessions of 1 Hz rTMS or placebo targeted to the left auditory cortex corresponding to tonotopic representation of tinnitus pitch. Effects were evaluated immediately after treatment and at 1, 3 and 6 months. Primary outcome measures were visual analogue scores (VAS 0–100) for tinnitus intensity, annoyance and distress, and the Tinnitus Handicap Inventory (THI). <i>Study sample:</i> Thirty-nine patients (mean age 50.3 years). <i>Results</i>: The mean tinnitus intensity (<i>F</i><sub>3</sub> = 15.7, <i>p</i> F<sub>3</sub> = 8.8, <i>p</i> = 0.0002), distress (<i>F</i><sub>3</sub> = 9.1, <i>p</i> = 0.0002) and THI scores (<i>F</i><sub>4</sub> = 13.8, <i>p</i> p = 0.082 and <i>p</i> = 0.065). <i>Conclusions</i>: Despite the significant effects of rTMS on tinnitus, differences between active and placebo groups remained non-significant, due to large placebo-effect and wide inter-individual variation.
DOI: 10.6084/m9.figshare.4884245.v2
title: Electric field-navigated transcranial magnetic stimulation for chronic tinnitus: a randomized, placebo-controlled study

description: <i>Objective</i>: Repetitive transcranial magnetic stimulation (rTMS) may alleviate tinnitus. We evaluated effects of electric field (E-field) navigated rTMS targeted according to tinnitus pitch. No controlled studies have investigated anatomically accurate E-field-rTMS for tinnitus. <i>Design</i>: Effects of E-field-rTMS were evaluated in a prospective randomised placebo-controlled 6-month follow-up study on parallel groups. Patients received 10 sessions of 1 Hz rTMS or placebo targeted to the left auditory cortex corresponding to tonotopic representation of tinnitus pitch. Effects were evaluated immediately after treatment and at 1, 3 and 6 months. Primary outcome measures were visual analogue scores (VAS 0–100) for tinnitus intensity, annoyance and distress, and the Tinnitus Handicap Inventory (THI). <i>Study sample:</i> Thirty-nine patients (mean age 50.3 years). <i>Results</i>: The mean tinnitus intensity (<i>F</i><sub>3</sub> = 15.7, <i>p</i> F<sub>3</sub> = 8.8, <i>p</i> = 0.0002), distress (<i>F</i><sub>3</sub> = 9.1, <i>p</i> = 0.0002) and THI scores (<i>F</i><sub>4</sub> = 13.8, <i>p</i> p = 0.082 and <i>p</i> = 0.065). <i>Conclusions</i>: Despite the significant effects of rTMS on tinnitus, differences between active and placebo groups remained non-significant, due to large placebo-effect and wide inter-individual variation.
DOI: 10.25592/uhhfdm.1502
title: Phon-CL2

description: Audio recordings of eight German participants in Spain, with Spanish as L2, children first exposed to their L2 at or before the age of three, and children exposed to their L2 at or after the age of five. Recording sessions in Spanish based on picture naming and story telling etc. Rich metadata on language use and attitudes in the family submitted by the parents. Phon-CL2 is a phonetically and orthographically transcribed corpus of German and Spanish, finalized in the project Prosodic constraints on phonological and morphological development in bilingual first language acquisition at the Research Center on Multilingualism, University of Hamburg. Ulloa, Marta Saceda, Conxita Lleó, and Izarbe Garcia Sanchez. 2012. "Corpora of Spoken Spanish by Simultaneous and Successive German-Spanish Bilingual and Spanish Monolingual Children." In Multilingual Corpora and Multilingual Corpus Analysis, edited by Thomas Schmidt and Kai Wörner, pp. 97–106. Hamburg Studies in Multilingualism, 14. John Benjamins. <strong>CLARIN Metadata summary for Phon-CL2 (CMDI-based)</strong> <strong>Title: </strong>Phon-CL2<br> <strong>Description: </strong>Audio recordings of eight German participants in Spain, with Spanish as L2, children first exposed to their L2 at or before the age of three, and children exposed to their L2 at or after the age of five. Recording sessions in Spanish based on picture naming and story telling etc. Rich metadata on language use and attitudes in the family submitted by the parents.<br> <strong>Data owner: </strong> Conxita Lleó, Institut für Romanistik / Von-Melle-Park 6 / D-20146 Hamburg, lleo@uni-hamburg.de<br> <strong>Contributors: </strong> Conxita Lleó, Institut für Romanistik / Von-Melle-Park 6 / D-20146 Hamburg, lleo@uni-hamburg.de (compiler)<br> <strong>Project: </strong> E3 "Prosodic Constraints on Phonological and Morphological development in Bilingual First Language Acquisition", German Research Foundation (DFG)<br> <strong>Keywords: </strong> child language acquisition, child bilingualism, successive bilingualism, child L2 acquisition, L2 data, adult bilingualism, EXMARaLDA<br> <strong>Languages: </strong> German (deu), Spanish (spa)<br> <strong>Size: </strong> 22 speakers (8 female, 14 male), 26 communications, 0 recordings, 0 minutes, 26 transcriptions, 17412 words<br> <strong>Genre: </strong> discourse<br> <strong>Modality: </strong> spoken<br> <strong>References: </strong> Ulloa, Marta Saceda, Conxita Lleó, and Izarbe Garcia Sanchez. 2012. "Corpora of Spoken Spanish by Simultaneous and Successive German-Spanish Bilingual and Spanish Monolingual Children." In Multilingual Corpora and Multilingual Corpus Analysis, edited by Thomas Schmidt and Kai Wörner, pp. 97–106. Hamburg Studies in Multilingualism, 14. John Benjamins.