cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4750708.v1
title: Supplementary Material for: New Self-Reporting Questionnaire to Assess Urinary Tract Infections and Differential Diagnosis: Acute Cystitis Symptom Score

description: <strong><em>Objective:</em></strong> Development and validation of a simple and standardized self-reporting questionnaire for acute uncomplicated cystitis (AUC) assessing typical and differential symptoms, quality of life and possible changes after therapy in female patients with AUC. <b><i>Materials and Methods:</i></b> Literature research, development and evaluation of the Acute Cystitis Symptom Score (ACSS), an 18-item self-reporting questionnaire including (a) six questions about ‘typical' symptoms of AUC, (b) four questions regarding differential diagnoses, (c) three questions on quality of life and (d) five questions on additional conditions which may affect therapy. The ACSS was evaluated in 286 women (mean age 32.3 ± 12.3 years) in the Russian and Uzbek language. Measurements of reliability, validity, predictive ability and responsiveness were performed. <b><i>Results:</i></b> Cronbach's alpha for the ACSS was 0.89, split-half reliability was 0.92 and correlation between halves was 0.85. Mann-Whitney test revealed significant difference scores of the ‘typical' domain between patients and controls (10.75 vs. 2.02, p &lt; 0.001). The optimal threshold score was 6 points, with a 94% sensitivity and 90% specificity to predict AUC. The symptom score decreased significantly when comparing before and after therapy (10.7 vs. 2.1, p &lt; 0.001). <b><i>Conclusion:</i></b> The new validated ACSS is accurate enough and can be recommended for clinical studies and practice for initial diagnosis and monitoring treatment of AUC. Evaluation in other languages is in progress.
DOI: 10.6084/m9.figshare.4750702.v2
title: Shiny App - PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort

description: This deposit provides an interactive treemap for exploring the PARV4 prevalence data made available here: https://doi.org/10.6084/m9.figshare.4707316<br>Martin John Hadley is the data visualisation developer, and Philippa Matthews is the principal investigator and lead author for both the dataset and publications this visualisation is linked to.
DOI: 10.6084/m9.figshare.4750696
title: Genetic assessment of leech species from yak (<i>Bos grunniens</i>) in the tract of Northeast India

description: Yak is an iconic symbol of Tibet and high altitudes of Northeast India. It is highly cherished for milk, meat, and skin. However, yaks suffer drastic change in milk production, weight loss, etc, when infested by parasites. Among them, infestation by leeches is a serious problem in the Himalayan belt of Northeast India. The parasite feeds on blood externally or from body orifices, like nasopharynx, oral, rectum, etc. But there has been limited data about the leech species infesting the yak in that region because of the difficulties in morphological identification due to plasticity of the body, changes in shape, and surface structure and thus, warrants for the molecular characterization of leech. In anticipation, this study would be influential in proper identification of leech species infesting yak track and also helpful in inventorying of leech species in Northeast India. Here, we investigated, through combined approach of molecular markers and morphological parameters for the identification of leech species infesting yak. The DNA sequences of <i>COI</i> barcode fragment, <i>18S</i> and <i>28S rDNA,</i> were analyzed for species identification. The generated sequences were subjected to similarity match in global database and analyzed further through Neighbour-Joining, K2P distance based as well as ML approach. Among the three markers, only <i>COI</i> was successful in delineating species whereas the <i>18S</i> and <i>28S</i> failed to delineate the species. Our study confirmed the presence of the species from genus <i>Hirudinaria, Haemadipsa</i>, <i>Whitmania,</i> and one species <i>Myxobdella annandalae,</i> which has not been previously reported from this region.
DOI: 10.6084/m9.figshare.4750696.v1
title: Genetic assessment of leech species from yak (<i>Bos grunniens</i>) in the tract of Northeast India

description: Yak is an iconic symbol of Tibet and high altitudes of Northeast India. It is highly cherished for milk, meat, and skin. However, yaks suffer drastic change in milk production, weight loss, etc, when infested by parasites. Among them, infestation by leeches is a serious problem in the Himalayan belt of Northeast India. The parasite feeds on blood externally or from body orifices, like nasopharynx, oral, rectum, etc. But there has been limited data about the leech species infesting the yak in that region because of the difficulties in morphological identification due to plasticity of the body, changes in shape, and surface structure and thus, warrants for the molecular characterization of leech. In anticipation, this study would be influential in proper identification of leech species infesting yak track and also helpful in inventorying of leech species in Northeast India. Here, we investigated, through combined approach of molecular markers and morphological parameters for the identification of leech species infesting yak. The DNA sequences of <i>COI</i> barcode fragment, <i>18S</i> and <i>28S rDNA,</i> were analyzed for species identification. The generated sequences were subjected to similarity match in global database and analyzed further through Neighbour-Joining, K2P distance based as well as ML approach. Among the three markers, only <i>COI</i> was successful in delineating species whereas the <i>18S</i> and <i>28S</i> failed to delineate the species. Our study confirmed the presence of the species from genus <i>Hirudinaria, Haemadipsa</i>, <i>Whitmania,</i> and one species <i>Myxobdella annandalae,</i> which has not been previously reported from this region.
DOI: 10.7910/dvn/pkjufn/daff4k
title: FCC2003.242.ran

description: :unav
DOI: 10.6084/m9.figshare.4750690
title: Supplementary Material for: Induction of Phagocytosis and Intracellular Signaling by an Inhibitory Channel Catfish Leukocyte Immune-Type Receptor: Evidence for Immunoregulatory Receptor Functional Plasticity in Teleosts

description: Immunoregulatory receptors are categorized as stimulatory or inhibitory based on their engagement of unique intracellular signaling networks. These proteins also display functional plasticity, which adds versatility to the control of innate immunity. Here we demonstrate that an inhibitory catfish leukocyte immune-type receptor (IpLITR) also displays stimulatory capabilities in a representative myeloid cell model. Previously, the receptor IpLITR 1.1b was shown to inhibit natural killer cell-mediated cytotoxicity. Here we expressed IpLITR 1.1b in rat basophilic leukemia-2H3 cells and monitored intracellular signaling and functional responses. Although IpLITR 1.1b did not stimulate cytokine secretion, activation of this receptor unexpectedly induced phagocytosis as well as extracellular signal-related kinase 1/2- and protein kinase B (Akt)-dependent signal transduction. This novel IpLITR 1.1b-mediated response was independent of an association with the FcRγ chain and was likely due to phosphotyrosine-dependent adaptors associating with prototypical signaling motifs within the distal region of its cytoplasmic tail. Furthermore, compared to a stimulatory IpLITR, IpLITR 1.1b displayed temporal differences in the induction of intracellular signaling, and IpLITR 1.1b-mediated phagocytosis had reduced sensitivity to EDTA and cytochalasin D. Overall, this is the first demonstration of functional plasticity for teleost LITRs, a process likely important for the fine-tuning of conserved innate defenses.
DOI: 10.6084/m9.figshare.4750693
title: Additional files HIV diagnostic accuracy study

description: Additional files HIV diagnostic accuracy study <br><br>
DOI: 10.6084/m9.figshare.4750693.v1
title: Additional files HIV diagnostic accuracy study

description: Additional files HIV diagnostic accuracy study <br><br>
DOI: 10.6084/m9.figshare.4750705.v1
title: tamils.xlsx

description: These data include pregnancy cravings and indicators of nutrition, psychological distress, and resource scarcity.
DOI: 10.7910/dvn/pkjufn/gjgg1z
title: FCC2003.027.ran

description: :unav
DOI: 10.6084/m9.figshare.4750684
title: Supplementary Material for: Gastric Acid Suppression Is Associated with an Increased Risk of Adverse Outcomes in Inflammatory Bowel Disease

description: <i>Background:</i> The intestinal microbiota may influence inflammatory bowel disease (IBD) activity. Histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) can alter the intestinal microbiota. The aim of this study was to assess the relationship between H2RAs, PPIs, and IBD-related outcomes. <i>Methods:</i> We conducted a case-control study of IBD patients using the Veterans Health Affairs databases. Cases were defined by their first instance of an IBD-related hospitalization or surgery and the exposure of interest was H2RA or PPI use 30 days prior to the outcome. Incidence density ratios were calculated using conditional logistic regression. <i>Results:</i> In a cohort of 58,459 patients with IBD, we found 4,887 cases and 9,761 controls with ulcerative colitis (UC) and 4,876 cases and 9,745 controls with Crohn disease (CD). Filled prescriptions for H2RAs were associated with an increased risk of IBD-related hospitalization or surgery in CD patients (adjusted incidence density ratio 1.18; 95% CI 1.03-1.34). A similar association was found for PPIs in UC patients (adjusted incidence density ratio 1.11; 95% CI 1.02-1.21) and CD patients (adjusted incidence density ratio 1.12; 95% CI 1.02-1.22). <i>Conclusions:</i> H2RAs and PPIs were associated with a modestly increased risk of IBD-related hospitalization or surgery.
DOI: 10.6084/m9.figshare.4750675
title: Supplementary Material for: Perceptual Learning of Phonetic Information That Indicates Morphological Structure

description: Familiarity with a talker or accent can facilitate speech perception, but little is known about the acoustic-phonetic knowledge that is acquired during exposure to an unfamiliar talker, particularly with respect to how a talker realises grammatical and prosodic distinctions. The present experiment used relatively natural stimuli and tasks to investigate listeners' adaptation to a phonetic variant that is systematically associated with a morphological context, specifically the English /ri:/ prefix. Results showed that listeners who had previously been exposed to the atypical variant in /ri:/ prefixes in stories scored higher than control listeners in an intelligibility-in-noise task that included instances of the atypical variant. Perceptual learning was partly specific to the /ri:/ prefix, though there was weak generalisation of learning to word-initial /ri:/ syllables that were not prefixes. These results emphasise the value of developing context-sensitive, probabilistic models of speech perception which include multiple, parallel levels of representation.
DOI: 10.6084/m9.figshare.4750681
title: Supplementary Material for: Triflusal and Aspirin in the Secondary Prevention of Atherothrombotic Ischemic Stroke: A Very Long-Term Follow-Up

description: <strong><em>Background:</em></strong> The mean follow-up in the clinical trials of antiplatelet drugs in the secondary prevention of ischemic atherothrombotic stroke ranges from 1 to 5.5 years. Thus, the safety and efficacy of these drugs in the very long term is not totally documented. We have assessed the safety and effectiveness of triflusal and aspirin for a very long-term period in the secondary prevention of patients with ischemic atherothrombotic stroke. <b><i>Methods:</i></b> Patients with atherothrombotic ischemic stroke, including TIA, who participated in randomized clinical trials of triflusal versus aspirin were included in the study. The period of recruitment was between 1983 and 1999. After finishing their participation in the clinical trials, patients were followed up in the Neurology Department of our hospital. All patients were treated with aspirin or triflusal during a mean period of 17.2 years. Groups were comparable with respect to sex, age, risk factor and etiology of the stroke. Adverse events and vascular events (including stroke recurrence, ischemic heart disease and vascular death) that appeared throughout the study were registered. Statistical analysis was performed using the statistical package SPSS 15.0 for Windows. Kaplan-Meier curves and the log-rank test were used to compare treatments. <b><i>Results:</i></b> A total of 441 patients (305 men) with a mean age (±SD) of 51.1 ± 12.4 years were included in the study; 288 patients (65.3%) were treated with triflusal and 153 with aspirin. There were no statistically significant differences between aspirin and triflusal concerning new vascular events (72.5 vs. 60.4%; p = 0.28), stroke recurrence (49.7 vs. 46.5%; p = 0.53), ischemic heart events (54.9 vs. 55.6%; p = 0.90), vascular death (25.5 vs. 24%; p = 0.73) and global mortality (42.5 vs. 42%; p = 0.92). The incidence of serious bleeding (upper digestive tract hemorrhage and cerebral hemorrhage) was 18.3% in aspirin-treated patients and 5.5% in triflusal-treated patients (p &lt; 0.001). In reference to other adverse events, no significant differences were found between aspirin and triflusal. <b><i>Conclusions:</i></b> In the secondary prevention of ischemic stroke, very long-term treatment with triflusal or aspirin seems to have a similar efficacy, but triflusal is safer with a lower hemorrhagic risk. Triflusal may be an alternative therapy, particularly in patients who present aspirin resistance.
DOI: 10.7910/dvn/pkjufn/cjrfg9
title: FCC2002.219.ran

description: :unav
DOI: 10.6084/m9.figshare.4750681.v1
title: Supplementary Material for: Triflusal and Aspirin in the Secondary Prevention of Atherothrombotic Ischemic Stroke: A Very Long-Term Follow-Up

description: <strong><em>Background:</em></strong> The mean follow-up in the clinical trials of antiplatelet drugs in the secondary prevention of ischemic atherothrombotic stroke ranges from 1 to 5.5 years. Thus, the safety and efficacy of these drugs in the very long term is not totally documented. We have assessed the safety and effectiveness of triflusal and aspirin for a very long-term period in the secondary prevention of patients with ischemic atherothrombotic stroke. <b><i>Methods:</i></b> Patients with atherothrombotic ischemic stroke, including TIA, who participated in randomized clinical trials of triflusal versus aspirin were included in the study. The period of recruitment was between 1983 and 1999. After finishing their participation in the clinical trials, patients were followed up in the Neurology Department of our hospital. All patients were treated with aspirin or triflusal during a mean period of 17.2 years. Groups were comparable with respect to sex, age, risk factor and etiology of the stroke. Adverse events and vascular events (including stroke recurrence, ischemic heart disease and vascular death) that appeared throughout the study were registered. Statistical analysis was performed using the statistical package SPSS 15.0 for Windows. Kaplan-Meier curves and the log-rank test were used to compare treatments. <b><i>Results:</i></b> A total of 441 patients (305 men) with a mean age (±SD) of 51.1 ± 12.4 years were included in the study; 288 patients (65.3%) were treated with triflusal and 153 with aspirin. There were no statistically significant differences between aspirin and triflusal concerning new vascular events (72.5 vs. 60.4%; p = 0.28), stroke recurrence (49.7 vs. 46.5%; p = 0.53), ischemic heart events (54.9 vs. 55.6%; p = 0.90), vascular death (25.5 vs. 24%; p = 0.73) and global mortality (42.5 vs. 42%; p = 0.92). The incidence of serious bleeding (upper digestive tract hemorrhage and cerebral hemorrhage) was 18.3% in aspirin-treated patients and 5.5% in triflusal-treated patients (p &lt; 0.001). In reference to other adverse events, no significant differences were found between aspirin and triflusal. <b><i>Conclusions:</i></b> In the secondary prevention of ischemic stroke, very long-term treatment with triflusal or aspirin seems to have a similar efficacy, but triflusal is safer with a lower hemorrhagic risk. Triflusal may be an alternative therapy, particularly in patients who present aspirin resistance.
DOI: 10.6084/m9.figshare.4750666
title: Supplementary Material for: Expression Pattern of Smad4/GATA3 as a Predictor of Survival in Invasive Ductal Carcinoma of the Breast

description: <i>Background:</i> Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. <i>Methods:</i> The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. <i>Results:</i> Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. <i>Conclusion:</i> Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer.
DOI: 10.7910/dvn/pkjufn/uslvhm
title: FCC2002.047.ran

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DOI: 10.7910/dvn/pkjufn/yleqaj
title: FCC2002.280.ran

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DOI: 10.7910/dvn/pkjufn/rxxbti
title: FCC2002.108.ran

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DOI: 10.6084/m9.figshare.4750621
title: Molecular simulations of entangled defect structures around nanoparticles in nematic liquid crystals

description: We investigate the defect structures forming around two nanoparticles in a Gay–Berne nematic liquid crystal using molecular simulations. For small separations, disclinations entangle both particles forming the figure of eight, the figure of omega and the figure of theta. These defect structures are similar in shape and occur with a comparable frequency to micron-sized particles studied in experiments. The simulations reveal fast transitions from one defect structure to another suggesting that particles of nanometre size cannot be bound together effectively. We identify the ‘three-ring’ structure observed in previous molecular simulations as a superposition of the different entangled and non-entangled states over time and conclude that it is not itself a stable defect structure.
DOI: 10.6084/m9.figshare.4750630.v1
title: protocole_55.pdf

description: Résultats des MM16/17 pour les 3 reines dans le protocole 55.
DOI: 10.7910/dvn/pkjufn/nx1q2t
title: FCC2001.216.ran

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title: FCC2002.358.ran

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DOI: 10.7910/dvn/pkjufn/eet5cj
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title: FCC2002.142.ran

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DOI: 10.7910/dvn/v1rjpf/7dnlsh
title: cbb20150507_03.txt.gz

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DOI: 10.7910/dvn/v1rjpf/appebh
title: cbb20150505_03.txt.gz

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DOI: 10.7910/dvn/v1rjpf/n8qgr2
title: cbb20151113_03.txt.gz

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DOI: 10.7910/dvn/v1rjpf/hta98y
title: cbb20150128_03.txt.gz

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DOI: 10.6084/m9.figshare.4749892
title: BRID_data.txt

description: Data to accompany:Levine et al. Evaluating a new method for reconstructing forest conditions from General Land Office survey records. Ecological Applications.
DOI: 10.6084/m9.figshare.4749691
title: LW_2016_WingImages_NutritionalManipulation

description: Images of <i>Drosophila melanogaster</i> wings from an experimental manipulation of nutrition.
DOI: 10.6084/m9.figshare.4749664
title: lmksfile.txt

description: The data comprise 3D landmarks collected on the skulls of rats selected for either tameness of aggression.
DOI: 10.6084/m9.figshare.4749691.v1
title: LW_2016_WingImages_NutritionalManipulation

description: Images of Drosophila melanogaster wings from an experimental manipulation of nutrition.
DOI: 10.6084/m9.figshare.4749727
title: BAU Workshop Materials and Interaction Cards v1

description: A set of 'Customer Interaction Cards' and an accompanying set of workshop materials. These can be used to explore and design potential futures for Business as Unusual, and map novel customer journeys through these new models.