cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6121505.v1
title: Supplementary Material for: Study of the Association of <b><i>PEAR1</i></b>,<b><i> P2Y12</i></b>, and <b><i>UGT2A1</i></b> Polymorphisms with Platelet Reactivity in Response to Dual Antiplatelet Therapy in Chinese Patients

description: <b><i>Objectives:</i></b> Genetic variation is thought to contribute to considerable interindividual variability in platelet function, and there is a pressing need to identify genetic markers that can be used to predict the response to treatment. Our study investigated whether <i>PEAR1</i>,<i> P2Y12</i>, and <i>UGT2A1</i> polymorphisms were associated with platelet reactivity in response to dual antiplatelet therapy in Chinese patients with acute coronary syndrome. <b><i>Methods:</i></b> Patients with inhibition of platelet aggregation (IPA) &lt; 30% after treatment were classified as the high platelet reactivity (HPR) group. Patients with IPA &gt; 30% were classified as the normal platelet reactivity (NPR) group. ADP-induced platelet aggregation was measured by thromboelastography (TEG) platelet-mapping assay. Thirteen single nucleotide polymorphisms (SNPs) of <i>PEAR1</i>, <i>P2Y12</i> and <i>UGT2A1</i> were genotyped using the Mass­ARRAY platform. <b><i>Results:</i></b> Seven SNPs were significantly associated with ADP-induced platelet aggregation by univariate analysis. Major allele G at rs12041331, minor allele G at rs2644592, minor allele C at rs11264580, and minor allele C at rs11249454 were significantly associated with HPR, whereas minor allele T at rs57731889, minor allele A at rs16863356, and minor allele T at rs7634096 were significantly associated with NPR. The mean IPA was significantly lower in patients suffering recurrent ischemic events than in patients without recurrent events in our study (<i>p =</i> 0.048). <b><i>Conclusions:</i></b> Our findings suggest that <i>PEAR1</i>,<i> P2Y12</i>, and<i> UGT2A1</i> genetic variants may be potential biomarkers that can be used to guide clinical applications of clopidogrel and aspirin in Chinese patients.
DOI: 10.6084/m9.figshare.28606919.v5
title: HD-SC-1：石器文物高光谱数据集

description: <b><i>该数据集包含来自中国大足石刻的 28,193 个高光谱层。数据集的光谱范围从 400 到 1000 nm 不等，图像分辨率为 2048×2046 像素。此外，该数据集包含 233 个可见光空间特征、466 个可见光颜色特征和 6 个简单的劣化分类表。本研究的主要目的是提高石器文物劣化模式的识别准确性，并深化相关机制研究。</i></b><i>由于 figshare 空间和传输速度的限制，上传了一些示例数据。完整的数据上传到百度网盘（Spectral：https：//pan.baidu.com/s/10ZtYvtx8MFa32Vmz5j1V4A Extracting code：HDSC）和阿里网盘（其他</i>：https://www.alipan.com/t/LilDFHdljfLdFnKaFoVz<i>）进行存储和共享。总计 282GB</i><br>
DOI: 10.6084/m9.figshare.19679538.v2
title: shipboard

description: the shipboard sections data in October 2019 and July 2021.
DOI: 10.6084/m9.figshare.20337501.v4
title: service trade data by mode of supply and service type.dta

description: This is the extraction of services trade statistics, from WTO, used for modes of supply analysis. The data is saved as STATA software format and in Excel. Data is extracted from WTO database available https://www.wto.org/english/news_e/news19_e/serv_31jul19_e.htm
DOI: 10.6084/m9.figshare.12236588.v1
title: Laporan kahoot: Berkenalan dengan Kahoot

description: Berikut ini merupakan contoh hasil laporan kahoot setelah dimainkan. Untuk melihat atau meninjau kahoot asli silakan cek tautan di bawah ini.
DOI: 10.6084/m9.figshare.28246127.v1
title: Genomes of picocyanobacteria Recovered from marine picocyanobacteria cultures

description: This dataset includes the assembled genomes ofpicocyanobacteria recovered from marine picocyanobacteria, The genomes were assembled from metagenomic sequencing data derived from these cultures. This dataset provides insights into the microbial diversity associated with marine microalgae, focusing on the bacterial species present. The data was generated using high-throughput sequencing technologies, including Illumina and Qitan Nanopore sequencing.
DOI: 10.6084/m9.figshare.5121340.v1
title: Supplementary Material for: The Morphology of the Rat Vibrissal Follicle-Sinus Complex Revealed by Three-Dimensional Computer-Aided Reconstruction

description: The vibrissal follicle-sinus complex (FSC) is a sensory receptor of the mammalian integumentary system that is located around the mouth. The purpose of the present study was to identify the actual 3-dimensional structure of the rat vibrissal FSC. Rat skin tissue was serially sectioned at a thickness of 10 µm and then stained with Masson’s trichrome. The serial sections were reconstructed 3-dimensionally using Reconstruct software. The rat vibrissal follicle is a spindle-shaped structure that is embedded within a blood sinus and enveloped within a thick collagenous capsule. The vibrissal FSC is innervated by the deep vibrissal and superficial vibrissal nerves. The deep vibrissal nerve, travelling in the basal-to-apical direction, penetrates the thick collagenous capsule of the vibrissal FSC. The sinus system can be divided into a superior portion, known as the ring sinus, and an inferior portion, known as the cavernous sinus. The ring sinus contains a C-shaped structure, the ringwulst, which is suspended from the mesenchymal sheath of the follicle. Collagenous trabeculae can be seen in the cavernous sinus but not in the ring sinus. The ring sinus encircles the follicle obliquely and asymmetrically. The ringwulst encircles the follicle incompletely, in a C-shaped fashion. This study has demonstrated the previously underappreciated 3-dimensional structure of the vibrissal FSC, which differs from previously reported descriptions, and provides data that will enhance the understanding of vibrissal function.
DOI: 10.6084/m9.figshare.c.3641699_d1.v1
title: Additional file 1: of Prediction of gestational age based on genome-wide differentially methylated regions

description: An Excel file containing information regarding CpGs and genes discussed in the present study. Table S1. All p B
DOI: 10.6084/m9.figshare.19096460.v1
title: Dataset, The Effect of Bimanual and Unimanual Robot-assisted Therapy for Upper Limb Function after Stroke

description: Aims: The main aim of the thesis was to evaluate and compare the effectiveness of two therapeutic approaches using robot-assisted glove Gloreha Sinfonia to perform Activity of daily living in patients after acquired brain injury. Methods: The study is an empirical quantitative research, a monocentric randomized controlled, simply blinded study. The study compares two groups, group A (n = 20) used a robot-assisted Gloreha glove with a bimanual approach, group B (n = 20) had therapy with a robot-assisted Gloreha glove with an unimanual approach. All patients were evaluated for eligibility and underwent initial testing (T1). Patients in both groups had therapy (unimanual / bimanual) for three weeks (15x), retest (T2) was performed after completion of the intervention, and a follow-up evaluation was performed after 1 month (T3). Patients were always evaluated by the Upper Extremity Motor Activity Log (UE MAL), Motor Assessment Scale (MAS), Action Research Arm Test (ARAT), Box and Block test (BBT) and Motricity Index (MI).
DOI: 10.17632/zj6k5r6xxg.1
title: EXPLANATORY MODEL OF SUBJECTIVE HAPPINESS OF MEDICAL STUDENTS COLOMBIA

description: A dataset compiled from medical students in five Colombian regions, encompassing variables related to psychological well-being (happiness, depression, anxiety, stress), lifestyle (alcohol and tobacco use, physical activity, sleep quality), religiosity, and family functioning."
DOI: 10.17632/zj6k5r6xxg.2
title: MENTAL HEALTH IN MEDICAL STUDENTS FROM FIVE REGIONS OF COLOMBIA

description: A dataset compiled from medical students in five Colombian regions, encompassing variables related to psychological well-being (happiness, depression, anxiety, stress), lifestyle (alcohol and tobacco use, physical activity, sleep quality), religiosity, and family functioning."
DOI: 10.17632/zj6k5r6xxg.3
title: MENTAL HEALTH IN MEDICAL STUDENTS FROM FIVE REGIONS OF COLOMBIA

description: A dataset compiled from medical students in five Colombian regions, encompassing variables related to psychological well-being (happiness, depression, anxiety, stress), lifestyle (alcohol and tobacco use, physical activity, sleep quality), religiosity, and family functioning."
DOI: 10.6084/m9.figshare.11347676.v1
title: RDF Datasets to Test Keyword Search Algorithms

description: This repository contains three RDF datasets used to test keyword search algorithms: 1) DBpedia, 2) IMDb, and 3) Mondial.<br>The DBpedia was created from the original version available at http://downloads.dbpedia.org/2016-10/. The IMDb and Mondial datasets are triplifications of the datasets originally created by Coffman, J.; and Weaver, A.C. (2012) and available at https://joel-coffman.github.io/resources.html.<br>The datasets contain, besides the original data, preprocessed data used by keyword search algorithms.
DOI: 10.17632/zj6k5r6xxg.4
title: MENTAL HEALTH IN MEDICAL STUDENTS FROM FIVE REGIONS OF COLOMBIA

description: A dataset compiled from medical students in five Colombian regions, encompassing variables related to psychological well-being (happiness, depression, anxiety, stress), lifestyle (alcohol and tobacco use, physical activity, sleep quality), religiosity, and family functioning."
DOI: 10.6084/m9.figshare.6715568.v1
title: LY Excell

description: iMSD analysis output of lysosomes movies
DOI: 10.6084/m9.figshare.20110463.v1
title: Data for: Predator and Pollinator? An Invasive Hornet Alters the Pollination Dynamics of a Native Plant

description: Impact of differing <em>V. velutina </em>abundance on insect diversity, flower visitation frequency, and predator-prey interactions. Resultant effects upon the pollination success of <em>H. hibernica</em>, in the form of fruit and seed set.
DOI: 10.6084/m9.figshare.7609766.v1
title: Dexmedetomidine on emergence delirium and postoperative behavioural changes.xlsx

description: This is a prospective, double-blind, randomized controlled study. The study was aimed to investigate the effects of single-dose dexmedetomidine on emergence delirium in children with sevoflurane anesthesia, and observe postoperative behavior changes through long-term follow-up. <br>
DOI: 10.6084/m9.figshare.16866559.v1
title: Supplementary Material for: Evidence Mapping of Proton Therapy, Heavy Ion Therapy, and Helical Tomotherapy for Gastric Cancer

description: <b><i>Purpose:</i></b> This study aimed to systematically present application situation and therapeutic effect of proton therapy (PT), heavy ion therapy, and helical tomotherapy (TOMO) for gastric cancer (GC), and to find gaps of existing studies. <b><i>Methods:</i></b> PubMed, EMBASE, the Cochrane Library, Web of Science, and Chinese Biological Medical Database were searched. Tables, bubble plot, and heat map were conducted to display results. <b><i>Results:</i></b> Fourteen studies were included. About PT, 7 single-arm studies showed median overall survival (OS) within 2–66 months and 1 study reported 40% of patients happened moderate degree of radiation gastritis. About TOMO, 1 study reported longer median OS and progression-free survival, lower occurrence of Grade III toxicity, and late toxicity compared to 3D-CRT, while another study remained neutral. About heavy ion therapy, there was no clinical study was found. <b><i>Conclusions:</i></b> Existing studies presented good clinic treatment effect about PT and TOMO for GC, and furthermore clinical studies are needed.
DOI: 10.6084/m9.figshare.21817578.v1
title: Trajectory and topology files for MD simulations of P3HT

description: Topology files for GROMACS simulations and relevant trajectory files (in a MATLAB format).
DOI: 10.6084/m9.figshare.25971637.v2
title: <b>Figure 1</b> Variability in Carbon to Nitrogen (C:N) ratios of plant Litter and microbial biomass as sources of soil organic matter in different ecosystems.

description: Data for “<b>Developing an Ecological Stoichiometry-Based Framework for Tracing the Sources of Soil Organic Matter</b>”
DOI: 10.6084/m9.figshare.25794027.v1
title: critical thinking skill data

description: This study explored the impact of the VaKE (Values and Knowledge Education) method applied in a discussion forum on the critical thinking skills of undergraduate students.
DOI: 10.6084/m9.figshare.27192897.v1
title: Behavioral raw data recorded by HABITS autonomously

description: Mice are among the most prevalent animal models in neuroscience, leveraging the extensive physiological, imaging and genetic tools available for studying their brain. However, the development of new behavioral paradigms for mice has been laborious and inconsistent, impeding the investigation of complex cognition. Here, we present a home-cage assisted mouse behavioral innovation and testing system (HABITS), enables free-moving mice learn challenging cognitive behaviors in their home-cage without any human involvement. Supported by the microcontroller-based general programming framework, we have not only replicated established paradigms in current neuroscience research but also developed several novel paradigms previously unexplored in mice, resulting in more than 300 mice tested in various cognition functions. Through a machine-teaching approach, HABITS can comprehensively optimize the presentation of stimuli and modalities for trials, leading to more efficient training and higher-quality behavioral outcomes. To our knowledge, this is the first instance where mouse behavior has been systematically optimized by an algorithmic approach. Our results open a new approach for mouse behavior and demonstrate the novel and optimized cognitions to be investigated at the neural level.
DOI: 10.6084/m9.figshare.28827542.v1
title: Research - public sector

description: Data for Greek Public Sector
DOI: 10.6084/m9.figshare.25366435.v1
title: WeiboText2012

description: This is a text data downloaded from Sina Weibo related to flood disasters.
DOI: 10.6084/m9.figshare.23631981.v1
title: Traits of social immune memory in a fungus-growing superorganism

description:  Scripts with all analysis, and raw data used in Goes et al., 2023
DOI: 10.6084/m9.figshare.26868883.v1
title: Supplementary Material for: Exploring Diagnostic and Therapeutic Odyssey in Pulmonary Arterial Hypertension: Insights from In-Depth Semi-Structured Interviews

description: Introduction
Establishing a diagnosis is paramount in medical practice as it shapes patients' experiences and guides treatment. Patients grappling with rare diseases face a triple challenge: prolonged diagnostic journeys, limited responses to existing therapies, and the absence of effective monitoring tools. Genetic diagnosis often provides crucial diagnostic and prognostic information, opening up possibilities for genotype-targeted treatments and facilitating counselling and relative testing. The NIHR BioResource - Rare Diseases (NBR) Study and the Cohort study in idiopathic and hereditary pulmonary arterial hypertension (PAH Cohort study) aimed to enhance diagnosis and treatment for PAH, successfully identifying the genetic cause in 25% of idiopathic cases. However, the diagnostic and therapeutic odyssey in patients with PAH remains largely unexplored.
Methods
Stakeholders from the NBR and PAH Cohort studies were recruited using purposive sampling. In-depth interviews and focus groups were recorded, transcribed, anonymised, and analysed thematically using MAXQDA software.
Results
The study involved 53 interviews and focus groups with 63 participants, revealing key themes across five stages of the diagnostic odyssey: initial health concerns and interactions with GPs, experiences of misdiagnosis, relief upon receiving the correct diagnosis, and mixed emotions regarding genetic results and the challenges of living with the disease. Following the diagnosis, participants embarked on a therapeutic journey, facing various challenges, including the disease's impact on professional and social lives, the learning curve associated with understanding the disease, shifts in communication dynamics with healthcare providers, therapeutic hurdles, and insurance-related issues. Building on these insights, we identified areas of unmet needs, such as improved collaboration with primary care providers and local hospitals, the provision of psychological support and counselling, and the necessity for ongoing patient education in the ever-evolving realms of research and therapy.
Conclusions
The study highlights the significant challenges encountered throughout the diagnostic and therapeutic journey in PAH. To enhance patient outcomes, it is crucial to raise awareness of the disease, establish clear diagnostic pathways, and seamlessly integrate genetic diagnostics into clinical practice. Streamlining the diagnostic process can be achieved by utilising existing clinical infrastructure to support research and fostering better communication within the NHS. Moreover, there is an urgent need for more effective therapies alongside less burdensome drug delivery methods.
DOI: 10.6084/m9.figshare.8972222.v1
title: Supplementary Material for: Survivin Impairs the Apoptotic Machinery in CD4<sup>+</sup> T Cells of Patients with Ulcerative Colitis

description: <b><i>Background:</i></b> The increase in CD4<sup>+</sup> T cell infiltration and overproduction of CD4<sup>+</sup> T cell-associated cytokines have been observed in the inflamed colon mucosa of patients with ulcerative colitis (UC); the underlying mechanisms are not fully understood. Survivin plays a critical role in the interference with apoptotic machinery. This study aims to elucidate the role of survivin in the interference with the apoptotic machinery in CD4<sup>+</sup> T cells of UC patients. <b><i>Methods:</i></b> Peripheral blood samples were collected from UC patients (UC group) and healthy subjects (healthy group). The apoptotic status in CD4<sup>+</sup> T cells was analyzed by flow cytometry. <b><i>Results:</i></b> We observed that the expression of survivin was significantly higher in CD4<sup>+</sup> T cells of UC patients than in healthy subjects. UC CD4<sup>+</sup> T cells were resistant to apoptosis induction. A complex of survivin and c-Myc, the transcription factor of FasL, was detected in CD4<sup>+</sup> T cells in UC patients, which prevented the binding of c-Myc to the FasL promoter and interfered with the expression of FasL. Increased expression of survivin prevented the activation-induced CD4<sup>+</sup> T cells from apoptosis. <b><i>Conclusions:</i></b> The data indicate that UC CD4<sup>+</sup> T cells express high levels of survivin, which impairs the apoptotic machinery in CD4<sup>+</sup> T cells and prevents the activation-induced CD4<sup>+</sup> T cell apoptosis. Therefore, target therapy against survivin has translational potential in the treatment of UC patients.
DOI: 10.6084/m9.figshare.26984632.v1
title: Supplementary Material for: Long-term change in BMI for children with obesity treated in family-centered lifestyle interventions

description: Introduction 
Several evaluations of lifestyle interventions for childhood obesity exist; however, follow-up beyond two years is necessary to validate the effect. The aim of the present study was to investigate long-term weight development following children participating in one of two pragmatic family-centered lifestyle interventions for children with obesity.

Methods 
This real-life observational study included Danish children 4-17 years of age classified as having obesity. Data from 2010-2020, from two community-based family-centered lifestyle interventions (designated hereafter as the Aarhus- and the Randers-intervention) were merged with national registers and routine health check-ups, including height and weight. Adjusted mixed effect models were used to model changes in Body Mass Index (BMI) z-score. We performed exploratory analyses of the development in BMI z-score within stratified subgroups of children treated in the interventions before investigating potential effect modifications induced by sex, age, family structure, socioeconomic or immigration status. 

Results 
With a median follow-up of 2.8 years (interquartile range: 1.3;4.8), 703 children participated in an intervention (445 the Aarhus-intervention; 258 the Randers-intervention) and 2,337 children were not invited to participate (no-intervention). 
Children in both interventions experienced a comparable reduction in BMI z-scores during the first 6 months compared to the no-intervention group (Aarhus-intervention: -0.12 SD/year and Randers-intervention: -0.25 SD/year). Only children in the Randers-intervention reduced their BMI z-score throughout follow-up (Aarhus-intervention vs. no-intervention: 0.01 SD/year; CI:-0.01;0.04; Randers-intervention vs. no-intervention: -0.05 SD/year; CI:-0.08;-0.02).
In a subgroup comparisons combining the two interventions, family income below the median (-0.05 SD/year, CI: -0.02;-0.09), immigrant background (0.04 SD/year, CI: 0.00; 0.07), or receiving intervention less than one year (0.04 SD/year, CI: 0.00;0.08) were associated with a yearly change in BMI z-score. In addition, effect modification analyses did not observe any interaction by sex, age, family structure, socioeconomic or immigration.

Conclusions 
Although the more dynamic intervention with longer duration obtained and sustained a minor reduction in BMI z-score, the clinical impact may only be modest.
However, this effect may at the best be only modest and still not effective enough to induce a long-term beneficial development in BMI in children with obesity.
DOI: 10.60893/figshare.jcp.26521111.v1
title: Supplement 1

description: Supplement 1
DOI: 10.6084/m9.figshare.25145819.v1
title: Yeast Macroecology 2023

description: Intermediate data files that can be used to reproduce Data for [Saccharomycotina yeasts defy long-standing macroecological patterns](https://doi.org/10.1073/pnas.2316031121)<b>species_sample_coordinates.txt </b>- all species coordinates after filtering steps as described in the manuscript<b>training_data.txt </b>- training data used for random forest species distribution models, details for each environmental variable are provided in supplemental dataset S6<b>species_distribution_maps</b><b>/</b><b> </b>- directory containing species distribution maps (pngs) predicted for every species in study that met performance thresholds<b>species_distribution_rasters/ </b>- directory containing raster files representing the predicted geographic distributions of every species included in study that met performance thresholds<br>
DOI: 10.6084/m9.figshare.28816250.v2
title: Multiomics analysis on polyamine metabolisms in colorectal cancer indicates important contribution of impaired anti-tumor activities of CXCR6<sup>+</sup>CD8<sup>+</sup>T cells by the extracellular putrescine

description: The models were reconstructed to randomly obtain three colons in each group. Lamina propria mononuclear cells (LPMC) were extracted as previously described (Wei et al. 2024). Whole cells from the colons were isolated using the RWD Intestine Enzymolysis Kit (DHIE-5007). The LPMC and whole cells with number ratio 1:1 were pooled into single-cell suspension for downstream construction of scRNA-seq libraries using a SeekOne® Digital Droplet single-cell 3’ transcriptome kit (SeekOne, Beijing) according to the manufacturer’s instructions. The scRNA-seq libraries were sequenced at Novogene (Co. Ltd., Beijing, China). The processing of the raw reads followed the same protocol as described previously (Shi et al. 2024). The downstream analysis in R software, including the quality filter, cluster annotation, and DEGs, was the same as mentioned above.
DOI: 10.6084/m9.figshare.26302261.v2
title: Datasets_for_AamTidalChannel

description: These datasets provide the mooring and casting observation results in the Aam tidal channel, Korea, recorded by Nortek ADV, HR ADCP, Signature 1000 ADCP, LISST, and CTD.