cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1569690.v1
title: Diagnostic characters in fossil coralline algae (Corallinophycidae: Rhodophyta) from the Miocene of southern Moravia (Carpathian Foredeep, Czech Republic)

description: Fourteen coralline algal species (Corallinales, Sporolithales) from Early Langhian (Lower Badenian) red-algal limestones of the Carpathian Foredeep (Czech Republic) are described: <i>Sporolithon lvovicum</i> (Maslov) Bassi <i>et al</i>., <i>Lithothamnion roveretoi</i> Airoldi, <i>Lithothamnion moretii</i> Lemoine, ?<i>Lithothamnion</i> sp. 1, ?<i>Lithothamnion</i> sp. 2, <i>Mesophyllum alternans</i> (Foslie) Cabioch & Mendoza, <i>M</i>. cf. <i>erubescens</i> (Foslie) Lemoine, <i>M</i>. cf. <i>printzianum</i> Woelkerling & Harvey, <i>M. curtum</i> Lemoine, <i>Phymatolithon</i> sp., <i>Lithophyllum</i> sp. 1, <i>Lithophyllum</i> sp. 2, <i>Hydrolithon lemoinei</i> (Miranda) Aguirre <i>et al</i>. and <i>Spongites fruticulosa</i> Kützing. The characters used in coralline algal species description and identification are summarized and discussed. Five characters newly used in fossil material are associated with the structure and fate of presumed tetrasporangial, gametangial and carposporangial conceptacles, with the shape, size and organization of roof cells, and with the position of the asexuate conceptacles relative to the surrounding thallus surface. Gametangial conceptacles of <i>Phymatolithon</i> and gametangial and carposporangial plants of <i>Sporolithon lvovicum</i> are described for the first time.
DOI: 10.6084/m9.figshare.1569691.v1
title: Quantification of CT-assessed radiation-induced lung damage in lung cancer patients treated with or without chemotherapy and cetuximab

description: <i>Background and Purpose</i>: Prediction models for radiation-induced lung damage (RILD) are still unsatisfactory, with clinical toxicity endpoints that are difficult to quantify objectively. We therefore evaluated RILD more objectively, quantitatively and on a continuous scale measuring the lung tissue density changes per voxel. <i>Material and methods</i>: Patients treated with radiotherapy (RT) alone, sequential and concurrent chemo-RT with and without the addition of cetuximab were studied. Follow-up computed tomography (CT) scans were co-registered using deformable registration to baseline CT scans. CT density changes were correlated to the RT dose delivered in every part of the lungs. <i>Results</i>: One hundred and seventeen lung cancer patients were included. Mean dose to tumor was 60 Gy (range 45–79.2 Gy). Dose response curves showed a linear increase in the dose region between 0 and 65 Gy having a slope (based on coefficients of the multilevel model) expressed as a lung density increase per dose of 0.86 (95% CI 0.73–0.99), 1.31 (95% CI 1.19–1.43), 1.39 (95% CI 1.28–1.50) and 2.07 (95% CI 1.93–2.21) for patients treated only with RT (N=19), sequential chemo-RT (N=30), concurrent chemo-RT (N=49), and concurrent chemo-RT with cetuximab (N=19), respectively. <i>Conclusions</i>: CT density changes allow quantitative assessment of lung damage after fractionated RT, giving complementary information to standard used clinical endpoints. Patients receiving cetuximab showed a significantly larger dose response compared with other treatments.
DOI: 10.6084/m9.figshare.1569674
title: Symptoms, signs, and tests: The general practitioner's comprehensive approach towards a cancer diagnosis

description: <i>Objective</i>. To study the relative importance of different tools a GP can use during the diagnostic process towards cancer detection. <i>Design</i>. Retrospective cohort study with prospective registration of cancer in general practice. <i>Setting and subjects</i>. One hundred and fifty-seven Norwegian general practitioners (GPs) reported 261 cancer patients. <i>Method</i>. During 10 consecutive days, GPs registered all patient consultations and recorded any presence of seven focal symptoms and three general symptoms, commonly considered as warning signs of cancer (WSC). Follow-up was done six to 11 months later. For each patient with new or recurrent cancer, the GP completed a questionnaire with medical-record-based information concerning the diagnostic procedure. <i>Results</i>. In 78% of cancer cases, symptoms, signs, or tests helped diagnose cancer. In 90 cases, there were 131 consultation-recorded WSC that seemed related to the cancer. Further symptoms were reported for another 74 cases. Different clinical signs were noted in 41 patients, 16 of whom had no previous recording of symptoms. Supplementary tests added information in 59 cases; in 25 of these there were no recordings of symptoms or signs. Sensitivity of any cancer-relevant symptom or clinical finding ranged from 100% for patients with uterine body cancer to 57% for patients with renal cancer. <i>Conclusion</i>. WSC had a major role as initiator of a cancer diagnostic procedure. Low-risk-but-not-no-risk symptoms also played an important role, and in 7% of patients they were the only symptoms. Clinical findings and/or supplementary procedures were sometimes decisive for rapid referral.
DOI: 10.6084/m9.figshare.1569674.v3
title: Symptoms, signs, and tests: The general practitioner's comprehensive approach towards a cancer diagnosis

description: <i>Objective</i>. To study the relative importance of different tools a GP can use during the diagnostic process towards cancer detection. <i>Design</i>. Retrospective cohort study with prospective registration of cancer in general practice. <i>Setting and subjects</i>. One hundred and fifty-seven Norwegian general practitioners (GPs) reported 261 cancer patients. <i>Method</i>. During 10 consecutive days, GPs registered all patient consultations and recorded any presence of seven focal symptoms and three general symptoms, commonly considered as warning signs of cancer (WSC). Follow-up was done six to 11 months later. For each patient with new or recurrent cancer, the GP completed a questionnaire with medical-record-based information concerning the diagnostic procedure. <i>Results</i>. In 78% of cancer cases, symptoms, signs, or tests helped diagnose cancer. In 90 cases, there were 131 consultation-recorded WSC that seemed related to the cancer. Further symptoms were reported for another 74 cases. Different clinical signs were noted in 41 patients, 16 of whom had no previous recording of symptoms. Supplementary tests added information in 59 cases; in 25 of these there were no recordings of symptoms or signs. Sensitivity of any cancer-relevant symptom or clinical finding ranged from 100% for patients with uterine body cancer to 57% for patients with renal cancer. <i>Conclusion</i>. WSC had a major role as initiator of a cancer diagnostic procedure. Low-risk-but-not-no-risk symptoms also played an important role, and in 7% of patients they were the only symptoms. Clinical findings and/or supplementary procedures were sometimes decisive for rapid referral.
DOI: 10.6084/m9.figshare.1569674.v2
title: Symptoms, signs, and tests: The general practitioner's comprehensive approach towards a cancer diagnosis

description: <i>Objective</i>. To study the relative importance of different tools a GP can use during the diagnostic process towards cancer detection. <i>Design</i>. Retrospective cohort study with prospective registration of cancer in general practice. <i>Setting and subjects</i>. One hundred and fifty-seven Norwegian general practitioners (GPs) reported 261 cancer patients. <i>Method</i>. During 10 consecutive days, GPs registered all patient consultations and recorded any presence of seven focal symptoms and three general symptoms, commonly considered as warning signs of cancer (WSC). Follow-up was done six to 11 months later. For each patient with new or recurrent cancer, the GP completed a questionnaire with medical-record-based information concerning the diagnostic procedure. <i>Results</i>. In 78% of cancer cases, symptoms, signs, or tests helped diagnose cancer. In 90 cases, there were 131 consultation-recorded WSC that seemed related to the cancer. Further symptoms were reported for another 74 cases. Different clinical signs were noted in 41 patients, 16 of whom had no previous recording of symptoms. Supplementary tests added information in 59 cases; in 25 of these there were no recordings of symptoms or signs. Sensitivity of any cancer-relevant symptom or clinical finding ranged from 100% for patients with uterine body cancer to 57% for patients with renal cancer. <i>Conclusion</i>. WSC had a major role as initiator of a cancer diagnostic procedure. Low-risk-but-not-no-risk symptoms also played an important role, and in 7% of patients they were the only symptoms. Clinical findings and/or supplementary procedures were sometimes decisive for rapid referral.
DOI: 10.6084/m9.figshare.1569663
title: Mid-Neoproterozoic Tadong amphibolites at the junction of the East Kunlun and Western Qinling Orogens – a record of continental rifting during the break-up of Rodinia

description: ABSTRACTMid-Neoproterozoic rift-related Tadong amphibolites (TDA) are situated in the junction of the East Kunlun Orogen (EKO) and the West Qinling Orogen (WQO) in western China, and have important significance in the break-up of the Supercontinent Rodinia. The mineral assemblage of the TDA exhibits amphibolite facies metamorphism, and the protolith is basic volcanic rocks. Here, we present a detailed laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) zircon U–Pb age and geochemical data of TDA. LA-ICP-MS U–Pb zircon age determination indicates that the basic volcanics formed at ca. 743–711 Ma. Geochemically, TDAs are characterized by low SiO<sub>2</sub> (46.06–50.18%), K<sub>2</sub>O (0.66–1.86%), and Mg<sup>#</sup> (40–45) and high TiO<sub>2</sub> (1.9–3.5%), and are attributed to tholeiite basalts. Their chondrite-normalized REE patterns are characterized by moderate enrichments in LREEs (LREE/HREE = 4.98–5.51) with insignificant Eu anomalies (<i>δ</i>Eu = 0.99–1.12). The primitive mantle-normalized trace element diagrams are characterized by pronounced enrichment of high-field-strength elements (HFSEs, e.g. REE, Nb, Ta, Zr, Hf) with slightly positive anomalies of Ti, which is different from the subduction zone basalts and normal mid-ocean ridge basalts (NMORBs), but similar to the ocean-island basalts (OIBs) and Emeishan continental flood basalts (ECFBs), resembling the features of an OIB-like mantle source. Most samples exhibit high Nb/Ta (16.6–17.4), Nb/La (0.70–0.94), and positive ΔNb (ΔNb = 1.74 + log (Nb/Y) − 1.92*log (Zr/Y)) values. These geochemical features suggest that the Tadong basaltic rocks were most likely derived from an OIB-like mantle source and were the products of a lower degree partial melting of garnet lherzolite. Along with the tectonic discrimination diagrams, it is further inferred that these rocks were formed in a continental rifting setting. These results from our research confirm the existence of continental rifting in the junction of the EKO and the WQO in the mid-late Neoproterozoic, implying that the rifting is a response to the break-up of the Supercontinent Rodinia.
DOI: 10.6084/m9.figshare.1569663.v1
title: Mid-Neoproterozoic Tadong amphibolites at the junction of the East Kunlun and Western Qinling Orogens – a record of continental rifting during the break-up of Rodinia

description: ABSTRACTMid-Neoproterozoic rift-related Tadong amphibolites (TDA) are situated in the junction of the East Kunlun Orogen (EKO) and the West Qinling Orogen (WQO) in western China, and have important significance in the break-up of the Supercontinent Rodinia. The mineral assemblage of the TDA exhibits amphibolite facies metamorphism, and the protolith is basic volcanic rocks. Here, we present a detailed laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) zircon U–Pb age and geochemical data of TDA. LA-ICP-MS U–Pb zircon age determination indicates that the basic volcanics formed at ca. 743–711 Ma. Geochemically, TDAs are characterized by low SiO<sub>2</sub> (46.06–50.18%), K<sub>2</sub>O (0.66–1.86%), and Mg<sup>#</sup> (40–45) and high TiO<sub>2</sub> (1.9–3.5%), and are attributed to tholeiite basalts. Their chondrite-normalized REE patterns are characterized by moderate enrichments in LREEs (LREE/HREE = 4.98–5.51) with insignificant Eu anomalies (<i>δ</i>Eu = 0.99–1.12). The primitive mantle-normalized trace element diagrams are characterized by pronounced enrichment of high-field-strength elements (HFSEs, e.g. REE, Nb, Ta, Zr, Hf) with slightly positive anomalies of Ti, which is different from the subduction zone basalts and normal mid-ocean ridge basalts (NMORBs), but similar to the ocean-island basalts (OIBs) and Emeishan continental flood basalts (ECFBs), resembling the features of an OIB-like mantle source. Most samples exhibit high Nb/Ta (16.6–17.4), Nb/La (0.70–0.94), and positive ΔNb (ΔNb = 1.74 + log (Nb/Y) − 1.92*log (Zr/Y)) values. These geochemical features suggest that the Tadong basaltic rocks were most likely derived from an OIB-like mantle source and were the products of a lower degree partial melting of garnet lherzolite. Along with the tectonic discrimination diagrams, it is further inferred that these rocks were formed in a continental rifting setting. These results from our research confirm the existence of continental rifting in the junction of the EKO and the WQO in the mid-late Neoproterozoic, implying that the rifting is a response to the break-up of the Supercontinent Rodinia.
DOI: 10.6084/m9.figshare.1569641
title: Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis

description: To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS). We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity. Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = −0.60; 95% CI: −0.81 to −0.38, <i>P</i> P P P = 0.018). The incidence of adverse effects in the tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding <i>Qmax</i> were showed in our meta-analysis. Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.
DOI: 10.6084/m9.figshare.1569641.v1
title: Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis

description: Objective:To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS).Methods:We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity.Results:Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = −0.60; 95% CI: −0.81 to −0.38, <i>P</i> P P P = 0.018). The incidence of adverse effects in the tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding <i>Qmax</i> were showed in our meta-analysis.Conclusions:Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.
DOI: 10.6084/m9.figshare.1569641.v2
title: Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis

description: Objective:To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS).Methods:We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity.Results:Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = −0.60; 95% CI: −0.81 to −0.38, <i>P</i> P P P = 0.018). The incidence of adverse effects in the tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding <i>Qmax</i> were showed in our meta-analysis.Conclusions:Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.
DOI: 10.6084/m9.figshare.1569641.v3
title: Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis

description: Objective:To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS).Methods:We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity.Results:Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = −0.60; 95% CI: −0.81 to −0.38, <i>P</i> P P P = 0.018). The incidence of adverse effects in the tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding <i>Qmax</i> were showed in our meta-analysis.Conclusions:Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.
DOI: 10.6084/m9.figshare.1569641.v5
title: Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis

description: To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS). We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity. Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = −0.60; 95% CI: −0.81 to −0.38, <i>P</i> P P P = 0.018). The incidence of adverse effects in the tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding <i>Qmax</i> were showed in our meta-analysis. Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.
DOI: 10.6084/m9.figshare.1569641.v4
title: Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis

description: Objective:To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS).Methods:We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity.Results:Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = −0.60; 95% CI: −0.81 to −0.38, <i>P</i> P P P = 0.018). The incidence of adverse effects in the tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding <i>Qmax</i> were showed in our meta-analysis.Conclusions:Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.
DOI: 10.6084/m9.figshare.1569616
title: SelectionOne_proJK1-LGK-CSV

description: Selection One CSV Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli<br>Justin R. Klesmith, John-Paul Bacik, Ryszard Michalczyk, and Timothy A. Whitehead<br>http://pubs.acs.org/doi/full/10.1021/acssynbio.5b00131<br>DOI: 10.1021/acssynbio.5b00131
DOI: 10.6084/m9.figshare.1569617
title: SelectionTwo_proNR2-LGK1-CombinedTiles

description: Selection Two Combined Tiles Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli<br>Justin R. Klesmith, John-Paul Bacik, Ryszard Michalczyk, and Timothy A. Whitehead<br>http://pubs.acs.org/doi/full/10.1021/acssynbio.5b00131<br>DOI: 10.1021/acssynbio.5b00131
DOI: 10.6084/m9.figshare.1569618
title: SelectionTwo_proNR2-LGK1-CSV

description: Selection Two - CSV Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli<br>Justin R. Klesmith, John-Paul Bacik, Ryszard Michalczyk, and Timothy A. Whitehead<br>http://pubs.acs.org/doi/full/10.1021/acssynbio.5b00131<br>DOI: 10.1021/acssynbio.5b00131
DOI: 10.6084/m9.figshare.1569616.v1
title: SelectionOne_proJK1-LGK-CSV

description: Selection One CSV Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli<br>Justin R. Klesmith, John-Paul Bacik, Ryszard Michalczyk, and Timothy A. Whitehead<br>http://pubs.acs.org/doi/full/10.1021/acssynbio.5b00131<br>DOI: 10.1021/acssynbio.5b00131
DOI: 10.6084/m9.figshare.1569617.v1
title: SelectionTwo_proNR2-LGK1-CombinedTiles

description: Selection Two Combined Tiles Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli<br>Justin R. Klesmith, John-Paul Bacik, Ryszard Michalczyk, and Timothy A. Whitehead<br>http://pubs.acs.org/doi/full/10.1021/acssynbio.5b00131<br>DOI: 10.1021/acssynbio.5b00131