cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22638723.v1
title: Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus

description: Abstract The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagnosis, treatment and activity. Twenty-eight SLE female patients (17 inactive, 11 active) and 10 healthy women were included in this study. Markers of natural killer (Nk), T and B cells in peripheral blood were evaluated by flow cytometry. Nkt cells were decreased only in SLE active patients. Activated CD4+, regulatory T FoxP3+ and B cells were decreased in both active and inactive SLE patients, compared to control group. The data corroborate the disruption of immune regulatory response in SLE patients and suggest phenotipic changes as possible biomarkers of SLE activity.
DOI: 10.6084/m9.figshare.22638726
title: Maternal Near Miss in Patients with Systemic Lupus Erythematosus

description: Abstract Objective Systemic lupus erythematosus (SLE) may cause irreversible organ damage. Pregnancy with SLE may have severe life-threatening risks. The present study aimed to determine the prevalence of severe maternal morbidity (SMM) in patients with SLE and analyze the parameters that contributed to cases of greater severity. Methods This is a cross-sectional retrospective study from analysis of data retrieved from medical records of pregnant women with SLE treated at a University Hospital in Brazil. The pregnant women were divided in a control group without complications, a group with potentially life-threatening conditions (PLTC), and a group with maternal near miss (MNM). Results The maternal near miss rate was 112.9 per 1,000 live births. The majority of PLTC (83.9%) and MNM (92.9%) cases had preterm deliveries with statistically significant increased risk compared with the control group (p = 0.0042; odds ratio [OR]: 12.05; 95% confidence interval [CI]: 1.5–96.6 for the MNM group and p = 0.0001; OR: 4.84; 95%CI: 2.2–10.8 for the PLTC group). Severe maternal morbidity increases the risk of longer hospitalization (p &lt; 0.0001; OR: 18.8; 95%CI: 7.0–50.6 and p &lt; 0.0001; OR: 158.17; 95%CI: 17.6–1424,2 for the PLTC and MNM groups, respectively), newborns with low birthweight (p = 0.0006; OR: 3.67; 95%CI: 1.7–7.9 and p = 0.0009; OR: 17.68; 95%CI: 2–153.6) for the PLTC and MNM groups, respectively] as well as renal diseases (PLTC [8.9%; 33/56; p = 0.0069] and MNM [78.6%; 11/14; p = 0.0026]). Maternal near miss cases presented increased risk for neonatal death (p = 0.0128; OR: 38.4; 95%CI: 3.3–440.3]), and stillbirth and miscarriage (p = 0.0011; OR: 7.68; 95%CI: 2.2–26.3]). Conclusion Systemic lupus erythematosus was significantly associated with severe maternal morbidity, longer hospitalizations, and increased risk of poor obstetric and neonatal outcomes.
DOI: 10.6084/m9.figshare.22638726.v1
title: Maternal Near Miss in Patients with Systemic Lupus Erythematosus

description: Abstract Objective Systemic lupus erythematosus (SLE) may cause irreversible organ damage. Pregnancy with SLE may have severe life-threatening risks. The present study aimed to determine the prevalence of severe maternal morbidity (SMM) in patients with SLE and analyze the parameters that contributed to cases of greater severity. Methods This is a cross-sectional retrospective study from analysis of data retrieved from medical records of pregnant women with SLE treated at a University Hospital in Brazil. The pregnant women were divided in a control group without complications, a group with potentially life-threatening conditions (PLTC), and a group with maternal near miss (MNM). Results The maternal near miss rate was 112.9 per 1,000 live births. The majority of PLTC (83.9%) and MNM (92.9%) cases had preterm deliveries with statistically significant increased risk compared with the control group (p = 0.0042; odds ratio [OR]: 12.05; 95% confidence interval [CI]: 1.5–96.6 for the MNM group and p = 0.0001; OR: 4.84; 95%CI: 2.2–10.8 for the PLTC group). Severe maternal morbidity increases the risk of longer hospitalization (p &lt; 0.0001; OR: 18.8; 95%CI: 7.0–50.6 and p &lt; 0.0001; OR: 158.17; 95%CI: 17.6–1424,2 for the PLTC and MNM groups, respectively), newborns with low birthweight (p = 0.0006; OR: 3.67; 95%CI: 1.7–7.9 and p = 0.0009; OR: 17.68; 95%CI: 2–153.6) for the PLTC and MNM groups, respectively] as well as renal diseases (PLTC [8.9%; 33/56; p = 0.0069] and MNM [78.6%; 11/14; p = 0.0026]). Maternal near miss cases presented increased risk for neonatal death (p = 0.0128; OR: 38.4; 95%CI: 3.3–440.3]), and stillbirth and miscarriage (p = 0.0011; OR: 7.68; 95%CI: 2.2–26.3]). Conclusion Systemic lupus erythematosus was significantly associated with severe maternal morbidity, longer hospitalizations, and increased risk of poor obstetric and neonatal outcomes.
DOI: 10.6084/m9.figshare.22638725
title: Nesting and foraging behaviour of the solitary bee Epanthidium tigrinum (Schrottky, 1905) bred in trap nests

description: ABSTRACT The bee Epanthidium tigrinum is native to Brazil and shows potential for use in pollinating agricultural crops. However, the little information available concerning its reproductive and feeding habits has prevented any rational breeding or management of these bees. The aim of this study was to investigate their acceptance of trap nests, and their nesting and foraging behaviour, with a view to understanding the potential of the species for rational breeding. Trap nests were offered, and the females were observed for 16 months to monitor the establishment, building and closing of nests, as well as their architecture and the behaviour of the bees when searching for the resources used to build and provision the nests. The results showed that E. tigrinum performs well in trap nests; prefers cavities with a diameter of around 0.45 cm; depends on other plant resources besides pollen and nectar, such as leaves, fibres and resins, to build its nest; and remains active throughout the year. The study concluded that the species has the potential for use in agricultural pollination programs; however the observed nesting requirements must be taken into account, both in conservation efforts and in zootechnical exploitation when breeding the bee for agricultural pollination, as both can influence the number of constructed nests and cells, and consequently, the size of the pollinator population.
DOI: 10.6084/m9.figshare.22638725.v1
title: Nesting and foraging behaviour of the solitary bee Epanthidium tigrinum (Schrottky, 1905) bred in trap nests

description: ABSTRACT The bee Epanthidium tigrinum is native to Brazil and shows potential for use in pollinating agricultural crops. However, the little information available concerning its reproductive and feeding habits has prevented any rational breeding or management of these bees. The aim of this study was to investigate their acceptance of trap nests, and their nesting and foraging behaviour, with a view to understanding the potential of the species for rational breeding. Trap nests were offered, and the females were observed for 16 months to monitor the establishment, building and closing of nests, as well as their architecture and the behaviour of the bees when searching for the resources used to build and provision the nests. The results showed that E. tigrinum performs well in trap nests; prefers cavities with a diameter of around 0.45 cm; depends on other plant resources besides pollen and nectar, such as leaves, fibres and resins, to build its nest; and remains active throughout the year. The study concluded that the species has the potential for use in agricultural pollination programs; however the observed nesting requirements must be taken into account, both in conservation efforts and in zootechnical exploitation when breeding the bee for agricultural pollination, as both can influence the number of constructed nests and cells, and consequently, the size of the pollinator population.
DOI: 10.6084/m9.figshare.21744143
title: Clock Drawing Test: Standard Data for Older Adults

description: Abstract This was a quantitative, retrospective, correlational, cross-sectional study that aimed to provide normative CDT (Clock-Drawing Test) data for older adults, taking into account different age groups and educational levels. The sample included 235 older adults distributed among five age groups and four levels of education. The instruments were Sociodemographic Data Sheet, the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale reduced version (GDS-15), the Semantic Verbal Fluency Task (TFVS), and the CDT. Descriptive statistics, Pearson’s correlation, and univariate analysis (one-way ANOVA) with Scheffe post hoc were used. The CDT scores showed significant associations with age, years of schooling, MMSE, TFVS, and GDS-15. There was a difference in performance in CDT when considering age groups. The present study was able to provide normative values for CDT in a sample of older adults in southern Brazil that were influenced by age, education, depressive symptoms, and verbal fluency.
DOI: 10.6084/m9.figshare.21744143.v1
title: Clock Drawing Test: Standard Data for Older Adults

description: Abstract This was a quantitative, retrospective, correlational, cross-sectional study that aimed to provide normative CDT (Clock-Drawing Test) data for older adults, taking into account different age groups and educational levels. The sample included 235 older adults distributed among five age groups and four levels of education. The instruments were Sociodemographic Data Sheet, the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale reduced version (GDS-15), the Semantic Verbal Fluency Task (TFVS), and the CDT. Descriptive statistics, Pearson’s correlation, and univariate analysis (one-way ANOVA) with Scheffe post hoc were used. The CDT scores showed significant associations with age, years of schooling, MMSE, TFVS, and GDS-15. There was a difference in performance in CDT when considering age groups. The present study was able to provide normative values for CDT in a sample of older adults in southern Brazil that were influenced by age, education, depressive symptoms, and verbal fluency.
DOI: 10.6084/m9.figshare.22638729.v1
title: Chemical characterization, cytotoxicity, antimicrobial and antioxidant potential of Justicia pectoralis Jacq and Croton jacobinensis Baill extracts

description: Abstract In this research, aqueous and ethanolic extracts from Justicia pectoralis Jacq and Croton Jacobinensis Baill were characterized. The UPLC-QTOF-MSE analysis was performed on the extracts identified, predominantly, flavonoids, tannins and acids. The extracts did not indicate toxicity in human epithelial cells. C. jacobinensis presented a concentration of phenolics 60.5% higher than J. pectoralis in all scenarios evaluated and, for both samples, the hydroalcoholic extract at 70% exhibited the best efficiency in the extraction (14501.3 and 32521.5 mg GAE 100 g-1 for J. pectoralis and C. jacobinensis, respectively). The antioxidant activity presented a positive correlation with the concentration of phenolics, being 1.186,1 and 1.507,9 μM of Trolox for J. pectoralis and C. jacobinensis at 70% of ethanol; however, it was not verified statistical difference between the ethanolic solutions (p &lt; 0.05). The antimicrobial activity of J. pectoralis extracts was highlighted once was the most effective against gram-positive bacteria. The results suggest that both J. pectoralis and C. jacobinensis extracts present the potential to be applied as natural additives due to their antioxidant and antimicrobial activity and safety. Thus, it is suggesting the development of studies that could investigate the interaction of these plant extracts with food matrices is required.
DOI: 10.6084/m9.figshare.22638729
title: Chemical characterization, cytotoxicity, antimicrobial and antioxidant potential of Justicia pectoralis Jacq and Croton jacobinensis Baill extracts

description: Abstract In this research, aqueous and ethanolic extracts from Justicia pectoralis Jacq and Croton Jacobinensis Baill were characterized. The UPLC-QTOF-MSE analysis was performed on the extracts identified, predominantly, flavonoids, tannins and acids. The extracts did not indicate toxicity in human epithelial cells. C. jacobinensis presented a concentration of phenolics 60.5% higher than J. pectoralis in all scenarios evaluated and, for both samples, the hydroalcoholic extract at 70% exhibited the best efficiency in the extraction (14501.3 and 32521.5 mg GAE 100 g-1 for J. pectoralis and C. jacobinensis, respectively). The antioxidant activity presented a positive correlation with the concentration of phenolics, being 1.186,1 and 1.507,9 μM of Trolox for J. pectoralis and C. jacobinensis at 70% of ethanol; however, it was not verified statistical difference between the ethanolic solutions (p &lt; 0.05). The antimicrobial activity of J. pectoralis extracts was highlighted once was the most effective against gram-positive bacteria. The results suggest that both J. pectoralis and C. jacobinensis extracts present the potential to be applied as natural additives due to their antioxidant and antimicrobial activity and safety. Thus, it is suggesting the development of studies that could investigate the interaction of these plant extracts with food matrices is required.
DOI: 10.6084/m9.figshare.22638732
title: Considerations for an urban health perspective in Chile from the “Quiero Mi Barrio” program

description: ABSTRACT OBJECTIVES To explore the perceptions of residents regarding their health and well-being in areas of personal and collective life, in relation to the experience of urban transformation originated by the Program for the Recovery of Neighborhoods in Chile “Quiero mi Barrio” (PQMB). METHODS Qualitative study conducted in eight neighborhoods, which were subject to interventions between 2012–2015, located in seven communes of Chile: Arica, Renca, Padre Las Casas, Villarrica, Castro, Ancud. Eighteen focus groups and 27 interviews were conducted between 2018 and 2019. A content analysis was carried out following the social determinants of health approach. RESULTS Material conditions of neighborhood infrastructure and psychosocial determinants were the main emerging and predominant categories in the residents’ narratives. The new or improved infrastructure enhances sports and playing practices, as well as contributes to the feeling of safety and to the improvement of walkable spaces, support networks, socialization and dynamization of social organization. However, neglected aspects were visualized. The program had limitations of structural character that operate locally, such as aging, individual lifestyles that limit participation, and contexts of insecurity, especially in neighborhoods victims of drug trafficking. CONCLUSIONS The urban changes originated by the PQMB included improvements in neighborhood infrastructure and in the psychosocial environment, which are perceived by residents as beneficial aspects and promoters of collective wellbeing. However, global phenomena, and those related to the program, limit its scope and have repercussions on the perception of overall wellbeing of the residents in the neighborhoods. To go deeper into how this or other state neighborhood programs may or may not favor equitable access of different social groups, or which works may be better used by the groups, is an aspect that enhances the integral action with other sectors and local actors in the territories.
DOI: 10.6084/m9.figshare.22638732.v1
title: Considerations for an urban health perspective in Chile from the “Quiero Mi Barrio” program

description: ABSTRACT OBJECTIVES To explore the perceptions of residents regarding their health and well-being in areas of personal and collective life, in relation to the experience of urban transformation originated by the Program for the Recovery of Neighborhoods in Chile “Quiero mi Barrio” (PQMB). METHODS Qualitative study conducted in eight neighborhoods, which were subject to interventions between 2012–2015, located in seven communes of Chile: Arica, Renca, Padre Las Casas, Villarrica, Castro, Ancud. Eighteen focus groups and 27 interviews were conducted between 2018 and 2019. A content analysis was carried out following the social determinants of health approach. RESULTS Material conditions of neighborhood infrastructure and psychosocial determinants were the main emerging and predominant categories in the residents’ narratives. The new or improved infrastructure enhances sports and playing practices, as well as contributes to the feeling of safety and to the improvement of walkable spaces, support networks, socialization and dynamization of social organization. However, neglected aspects were visualized. The program had limitations of structural character that operate locally, such as aging, individual lifestyles that limit participation, and contexts of insecurity, especially in neighborhoods victims of drug trafficking. CONCLUSIONS The urban changes originated by the PQMB included improvements in neighborhood infrastructure and in the psychosocial environment, which are perceived by residents as beneficial aspects and promoters of collective wellbeing. However, global phenomena, and those related to the program, limit its scope and have repercussions on the perception of overall wellbeing of the residents in the neighborhoods. To go deeper into how this or other state neighborhood programs may or may not favor equitable access of different social groups, or which works may be better used by the groups, is an aspect that enhances the integral action with other sectors and local actors in the territories.
DOI: 10.6084/m9.figshare.22638734
title: The Decision-Making Process for Developing Sustainable Innovation via Dynamic Capabilities in Cleantechs

description: Abstract This article aims to present a model of how the decision-making process can drive the development of dynamic capabilities for generating sustainable innovation in cleantech companies. Cleantechs are highly technological organizations, one of whose main characteristics is little or no use of non-renewable resources to produce any type of product, service, or process. The use of these technologies and identification of opportunities in the market makes sustainable innovation the core competence of this type of company. A multiple case study was conducted with cleantechs using a qualitative approach, supported by the content analysis technique. The primary data collection was carried out via semi-structured interviews, between October of 2020 and December of 2021, using an interview script as a collection instrument. The results provide a model that illustrates how the decision-making process can drive the development of dynamic capabilities for generating sustainable innovations, by means of categories that reflect technological sustainability, spillover effects, and a drive toward digitalization in clean technologies. The scientific contribution of the study is the presentation of how organizations can restructure their business models and develop sustainable and technological innovations, digitally leapfrogging to address bottlenecks related to energy rationing, social inclusion through monitoring technologies, access to low-cost clean and renewable energy, and other solutions.
DOI: 10.6084/m9.figshare.22638734.v1
title: The Decision-Making Process for Developing Sustainable Innovation via Dynamic Capabilities in Cleantechs

description: Abstract This article aims to present a model of how the decision-making process can drive the development of dynamic capabilities for generating sustainable innovation in cleantech companies. Cleantechs are highly technological organizations, one of whose main characteristics is little or no use of non-renewable resources to produce any type of product, service, or process. The use of these technologies and identification of opportunities in the market makes sustainable innovation the core competence of this type of company. A multiple case study was conducted with cleantechs using a qualitative approach, supported by the content analysis technique. The primary data collection was carried out via semi-structured interviews, between October of 2020 and December of 2021, using an interview script as a collection instrument. The results provide a model that illustrates how the decision-making process can drive the development of dynamic capabilities for generating sustainable innovations, by means of categories that reflect technological sustainability, spillover effects, and a drive toward digitalization in clean technologies. The scientific contribution of the study is the presentation of how organizations can restructure their business models and develop sustainable and technological innovations, digitally leapfrogging to address bottlenecks related to energy rationing, social inclusion through monitoring technologies, access to low-cost clean and renewable energy, and other solutions.
DOI: 10.6084/m9.figshare.22638735
title: ASYMMETRIC COST PASS THROUGH: SVAR ANALYSIS FOR BRAZIL UNDER INFLATION TARGETING REGIME (1999-2016)

description: ABSTRACT The aim of this article is to empirically analyze the peculiarities of the Brazilian economy that may explain the observed low rigidity of the Extended National Consumer Price Index (IPCA). We investigated the existence of asymmetry in the transmission of prices and heterogeneity in the inflationary dynamics among different sectors of the economy, as well as evaluated the passthrough of the exchange rate, commodity index, and industrial production to consumer prices (IPCA) and producer (Price Index to the Wide Producer - IPA). The IPCA was split into food and beverages, industrialized products, service provision, and monitored prices. Estimations were performed using symmetric and asymmetric models of Structural Autoregressive Vectors (SVAR). The results indicated that the exchange rate is the most relevant variable in the dynamics of the IPCA, followed by the commodities index. Industrial production was less relevant than external factors, including the model for industrialized products. It was noted a positive asymmetry in the exchange rate pass-through in all IPCA breakdowns. The main conclusion is that cost shocks should not be treated as mere white noises, with a zero average and that, therefore, compensate in time.
DOI: 10.6084/m9.figshare.22638735.v1
title: ASYMMETRIC COST PASS THROUGH: SVAR ANALYSIS FOR BRAZIL UNDER INFLATION TARGETING REGIME (1999-2016)

description: ABSTRACT The aim of this article is to empirically analyze the peculiarities of the Brazilian economy that may explain the observed low rigidity of the Extended National Consumer Price Index (IPCA). We investigated the existence of asymmetry in the transmission of prices and heterogeneity in the inflationary dynamics among different sectors of the economy, as well as evaluated the passthrough of the exchange rate, commodity index, and industrial production to consumer prices (IPCA) and producer (Price Index to the Wide Producer - IPA). The IPCA was split into food and beverages, industrialized products, service provision, and monitored prices. Estimations were performed using symmetric and asymmetric models of Structural Autoregressive Vectors (SVAR). The results indicated that the exchange rate is the most relevant variable in the dynamics of the IPCA, followed by the commodities index. Industrial production was less relevant than external factors, including the model for industrialized products. It was noted a positive asymmetry in the exchange rate pass-through in all IPCA breakdowns. The main conclusion is that cost shocks should not be treated as mere white noises, with a zero average and that, therefore, compensate in time.