cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9870356
title: Effect of probiotic Lactobacillus reuteri XC1 coexpressing endoglucanase and phytase on intestinal pH and morphology, carcass characteristics, meat quality, and serum biochemical indexes of broiler chickens

description: ABSTRACT This study investigated the effect of transformed Lactobacillys reuteri on intestinal pH and morphology, carcass characteristics, meat quality, and serum biochemical indexes of broiler chickens. A total of 480 broilers were assigned to six treatment groups and fed a phosphorus-adequate diet, a phosphorus-deficient diet, or a phosphorus-deficient diet containing different L. reuteri recombinants. The results showed that transformed L. reuteri decreased the pH in the duodenum and jejunum of chickens at day 21, decreased drip loss and cooking loss of muscles, and improved muscle tenderness of chickens at days 21 and 42, but did not affect carcass characteristics and only slightly decreased abdominal fat. Transformed L. reuteri also significantly increased calcium, phosphorus, and glucose levels, decreased the uric acid level of serum at day 21, and significantly increased the glucose level and decreased the triglycerides of serum on day 42. L. reuteri pLEM4159-cel/phy increased the villi height in the duodenum of chickens at days 21 and 42. The transformed L. reuteri decreased the crypt depth in the duodenum and jejunum of chickens at day 21 and also decreased the crypt depth in the ileum and increased the villi height in the duodenum at day 42. L. reuteri pLEM4158 (phy) and L. reuteri pLEM4159-cel/phy improved the villi height in the ileum at day 42. Taken together, transformed L. reuteri can improve blood calcium, phosphorus, and glucose metabolism and intestinal development in broilers, but does not affect carcass characteristics.
DOI: 10.6084/m9.figshare.9870356.v1
title: Effect of probiotic Lactobacillus reuteri XC1 coexpressing endoglucanase and phytase on intestinal pH and morphology, carcass characteristics, meat quality, and serum biochemical indexes of broiler chickens

description: ABSTRACT This study investigated the effect of transformed Lactobacillys reuteri on intestinal pH and morphology, carcass characteristics, meat quality, and serum biochemical indexes of broiler chickens. A total of 480 broilers were assigned to six treatment groups and fed a phosphorus-adequate diet, a phosphorus-deficient diet, or a phosphorus-deficient diet containing different L. reuteri recombinants. The results showed that transformed L. reuteri decreased the pH in the duodenum and jejunum of chickens at day 21, decreased drip loss and cooking loss of muscles, and improved muscle tenderness of chickens at days 21 and 42, but did not affect carcass characteristics and only slightly decreased abdominal fat. Transformed L. reuteri also significantly increased calcium, phosphorus, and glucose levels, decreased the uric acid level of serum at day 21, and significantly increased the glucose level and decreased the triglycerides of serum on day 42. L. reuteri pLEM4159-cel/phy increased the villi height in the duodenum of chickens at days 21 and 42. The transformed L. reuteri decreased the crypt depth in the duodenum and jejunum of chickens at day 21 and also decreased the crypt depth in the ileum and increased the villi height in the duodenum at day 42. L. reuteri pLEM4158 (phy) and L. reuteri pLEM4159-cel/phy improved the villi height in the ileum at day 42. Taken together, transformed L. reuteri can improve blood calcium, phosphorus, and glucose metabolism and intestinal development in broilers, but does not affect carcass characteristics.
DOI: 10.6084/m9.figshare.9870392
title: Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways

description: Abstract Purpose: To investigate the effect of astragaloside IV (As-IV) on myocardial ischemia-reperfusion (I/R) injury in rats and reltaed mechanisms. Methods: Sixty rats were randomly divided into sham-operated, control I/R and 2.5, 5 and 10 mg/kg As-IV groups, 12 rats in each group. The later three groups were intragastrically administered with As-IV for 7 days, with a dose of 2.5, 5 and 10 mg/kg, respectively. The myocardial I/R injury model was constructed in later four groups. At the end of reperfusion, the cardiac function indexes, serum lactate dehydrogenase (LDH) and creatine kinase (CK) levels, heart weight (HW)/body weight (BW) ratio and infarct size, and expressions of phosphatidylinositol-3 kinase/serine-threonine protein kinase (PI3K/AKT) and glycogen synthase kinase-3β (GSK-3β) proteins and the phosphorylated forms (p-AKT, p-GSK-3β) were determined. Results: Compared with control I/R group, in 5 and 10 mg/kg As-IV groups the left ventricular systolic pressure, fractional shortening and ejection fraction were increased, the left ventricular end-diastolic pressure was decreased, the serum LDH and CK levels were decreased, the HW/BW ratio and myocardial infarct size were decreased, and the p-Akt/Akt ratio and p-GSK-3β/GSK-3β ratio were increased (all P &lt; 0.05). Conclusion: As-IV can alleviate the myocardial I/R injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways.
DOI: 10.6084/m9.figshare.9870392.v1
title: Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways

description: Abstract Purpose: To investigate the effect of astragaloside IV (As-IV) on myocardial ischemia-reperfusion (I/R) injury in rats and reltaed mechanisms. Methods: Sixty rats were randomly divided into sham-operated, control I/R and 2.5, 5 and 10 mg/kg As-IV groups, 12 rats in each group. The later three groups were intragastrically administered with As-IV for 7 days, with a dose of 2.5, 5 and 10 mg/kg, respectively. The myocardial I/R injury model was constructed in later four groups. At the end of reperfusion, the cardiac function indexes, serum lactate dehydrogenase (LDH) and creatine kinase (CK) levels, heart weight (HW)/body weight (BW) ratio and infarct size, and expressions of phosphatidylinositol-3 kinase/serine-threonine protein kinase (PI3K/AKT) and glycogen synthase kinase-3β (GSK-3β) proteins and the phosphorylated forms (p-AKT, p-GSK-3β) were determined. Results: Compared with control I/R group, in 5 and 10 mg/kg As-IV groups the left ventricular systolic pressure, fractional shortening and ejection fraction were increased, the left ventricular end-diastolic pressure was decreased, the serum LDH and CK levels were decreased, the HW/BW ratio and myocardial infarct size were decreased, and the p-Akt/Akt ratio and p-GSK-3β/GSK-3β ratio were increased (all P &lt; 0.05). Conclusion: As-IV can alleviate the myocardial I/R injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways.
DOI: 10.6084/m9.figshare.11967594
title: data_scm.xlsx

description: this dataset is to detect the time lag effect of supply chain management and financial performance.
DOI: 10.5519/qd.381sa4zb
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.6084/m9.figshare.18259061
title: Realizing topological edge states with Rydberg-atom synthetic dimensions: Codes

description: Contains code used for Decoherence model in the paper titled "Realizing topological edge states with Rydberg-atom synthetic dimensions".
DOI: 10.6084/m9.figshare.9870608
title: Incidence and risk factors for major infections in hospitalized children with nephrotic syndrome

description: ABSTRACT Introduction: Children with nephrotic syndrome are at increased risk of infections because of disease status itself and use of various immunosuppressive agents. In majority, infections trigger relapses requiring hospitalization with increased risk of morbidity and mortality. This study aimed to determine the incidence, spectrum, and risk factors for major infections in hospitalized children with nephrotic syndrome. Methods: All consecutive hospitalized children between 1-12 years of age with nephrotic syndrome were enrolled in the study. Children with acute nephritis, secondary nephrotic syndrome as well as those admitted for diagnostic renal biopsy and intravenous cyclophosphamide or rituximab infusion were excluded. Results: A total of 148 children with 162 admissions were enrolled. Incidence of major infections in hospitalized children with nephrotic syndrome was 43.8%. Peritonitis was the commonest infection (24%), followed by pneumonia (18%), urinary tract infection (15%), and cellulitis (14%), contributing with two thirds of major infections. Streptococcus pneumoniae (n = 9) was the predominant organism isolated in children with peritonitis and pneumonia. On logistic regression analysis, serum albumin &lt; 1.5gm/dL was the only independent risk factor for all infections (OR 2.6; 95% CI, 1.2-6; p = 0.01), especially for peritonitis (OR 29; 95% CI, 3-270; p = 0.003). There were four deaths (2.5%) in our study, all due to sepsis and multiorgan failure. Conclusions: Infection remains an important cause of morbidity and mortality in children with nephrotic syndrome. As Pneumococcus was the most prevalent cause of infection in those children, attention should be paid to the pneumococcal immunization in children with nephrotic syndrome.
DOI: 10.6084/m9.figshare.9870608.v1
title: Incidence and risk factors for major infections in hospitalized children with nephrotic syndrome

description: ABSTRACT Introduction: Children with nephrotic syndrome are at increased risk of infections because of disease status itself and use of various immunosuppressive agents. In majority, infections trigger relapses requiring hospitalization with increased risk of morbidity and mortality. This study aimed to determine the incidence, spectrum, and risk factors for major infections in hospitalized children with nephrotic syndrome. Methods: All consecutive hospitalized children between 1-12 years of age with nephrotic syndrome were enrolled in the study. Children with acute nephritis, secondary nephrotic syndrome as well as those admitted for diagnostic renal biopsy and intravenous cyclophosphamide or rituximab infusion were excluded. Results: A total of 148 children with 162 admissions were enrolled. Incidence of major infections in hospitalized children with nephrotic syndrome was 43.8%. Peritonitis was the commonest infection (24%), followed by pneumonia (18%), urinary tract infection (15%), and cellulitis (14%), contributing with two thirds of major infections. Streptococcus pneumoniae (n = 9) was the predominant organism isolated in children with peritonitis and pneumonia. On logistic regression analysis, serum albumin &lt; 1.5gm/dL was the only independent risk factor for all infections (OR 2.6; 95% CI, 1.2-6; p = 0.01), especially for peritonitis (OR 29; 95% CI, 3-270; p = 0.003). There were four deaths (2.5%) in our study, all due to sepsis and multiorgan failure. Conclusions: Infection remains an important cause of morbidity and mortality in children with nephrotic syndrome. As Pneumococcus was the most prevalent cause of infection in those children, attention should be paid to the pneumococcal immunization in children with nephrotic syndrome.
DOI: 10.15151/esrf-es-1442319257
title: Magnetic exchange switching in a series of niobium(IV)-based molecular magnets: chemical design vs. mechanical stimulus

description: A series of isostructural magnetic coordination polymers {[MII(pyrazole)4]2[NbIV(CN)8].4H2O}n (M = Mn, Fe, Co, Ni for 1, 2, 3 and 4, respectively) show long-range magnetic ordering below 24, 8, 6 and 13 K due to the strong magnetic coupling between M and Nb. The exchange coupling changes from -6.8 for 1, through -3.1 for 2, +3.5 for 3 to +8.1 cm-1 for 4. This affects the nature of the long-range magnetic ordering in the 1-4 series: ferrimagnetic in 1 and 2 with antiparallael alignment of the Mn-Nb and Fe-Nb magnetic moments to ferromagnetic in 3 and 4 with parallel alignment. The proposed XAS/XMCD experiments performed at the Nb L2,3 edges with the application of sum rules are the only reliable way to unequivocally determine the magnetic structure of the four compounds. Moreover, compound 3 demonstrates switching of the type of long-range magnetic ordering under pressure. This will also be investigated by collecting XAS/XMCD spectra at the Nb L2,3 edge under high pressure.
DOI: 10.6084/m9.figshare.20356374
title: Additional file 3 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 3: Table S3. Differentially expressed miRNAs in tumor and adjacent tissues.
DOI: 10.6084/m9.figshare.20356368
title: Additional file 1 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 1: Table S1. DNA oligo sequences.
DOI: 10.6084/m9.figshare.20356368.v1
title: Additional file 1 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 1: Table S1. DNA oligo sequences.
DOI: 10.6084/m9.figshare.20356371
title: Additional file 2 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 2: Table S2. Patient information for analysis of C1GALT1 and T antigen expression in tumor and adjacent tissues.
DOI: 10.6084/m9.figshare.20356371.v1
title: Additional file 2 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 2: Table S2. Patient information for analysis of C1GALT1 and T antigen expression in tumor and adjacent tissues.
DOI: 10.6084/m9.figshare.20356374.v1
title: Additional file 3 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 3: Table S3. Differentially expressed miRNAs in tumor and adjacent tissues.
DOI: 10.6084/m9.figshare.20356377
title: Additional file 4 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 4: Table S4. Differentially expressed circRNAs in tumor and adjacent tissues.
DOI: 10.6084/m9.figshare.20356377.v1
title: Additional file 4 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 4: Table S4. Differentially expressed circRNAs in tumor and adjacent tissues.
DOI: 10.6084/m9.figshare.20356380
title: Additional file 5 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 5: Table S5. Proteins modified with T antigen identified in control and C1GALT1 silenced YTS-1 cells.
DOI: 10.6084/m9.figshare.20356380.v1
title: Additional file 5 of Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

description: Additional file 5: Table S5. Proteins modified with T antigen identified in control and C1GALT1 silenced YTS-1 cells.
DOI: 10.6084/m9.figshare.20356387
title: Additional file 2 of A novel splice site variant c.1183 + 1 G &gt; C in DFNA5 causing autosomal dominant nonsyndromic hearing loss in a Chinese family

description: Additional file 2. Supplementary table 2. The list of 3255 variants in Raw Data.
DOI: 10.6084/m9.figshare.20356390
title: Additional file 3 of A novel splice site variant c.1183 + 1 G &gt; C in DFNA5 causing autosomal dominant nonsyndromic hearing loss in a Chinese family

description: Additional file3. Supplementary table 3. Three variants retain after the filtering.
DOI: 10.6084/m9.figshare.20356390.v1
title: Additional file 3 of A novel splice site variant c.1183 + 1 G &gt; C in DFNA5 causing autosomal dominant nonsyndromic hearing loss in a Chinese family

description: Additional file3. Supplementary table 3. Three variants retain after the filtering.
DOI: 10.6084/m9.figshare.7773512
title: Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells

description: This aim of this study was to assess the molecular mechanism of osteoporosis in schizophrenia patients with risperidone use. Here, we investigated the effects of risperidone on cellular proliferation and apoptosis of a preosteoblast cell line, MC3T3-E1. Cell viability and apoptotic rate of MC3T3-E1 were detected by cell counting kit-8 and flow cytometry at a serial dose of risperidone and at different time points, respectively. Bone transformation relevant gene serum osteocalcin (BGP), collagen 1, tumor necrosis factor-α (TNF-α), osteoprotegerin (OPG), and receptor activator of nuclear factor-κB ligand (RANKL) mRNA levels were determined by real-time PCR (qPCR). Their protein expression patterns were evaluated using western blot. The results revealed that risperidone dramatically inhibited MC3T3-E1 cell proliferation in a dose-dependent manner. It also significantly induced MC3T3-E1 cell apoptosis. TNF-α gene and protein levels were greatly enhanced after risperidone treatment. In contrast, BGP, collagen 1, OPG, and RANKL gene and protein levels were markedly downregulated. Our study indicated that risperidone suppressed MC3T3-E1 cell proliferation and induced apoptosis. It also regulated BGP gene and protein expression.
DOI: 10.6084/m9.figshare.7773512.v1
title: Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells

description: This aim of this study was to assess the molecular mechanism of osteoporosis in schizophrenia patients with risperidone use. Here, we investigated the effects of risperidone on cellular proliferation and apoptosis of a preosteoblast cell line, MC3T3-E1. Cell viability and apoptotic rate of MC3T3-E1 were detected by cell counting kit-8 and flow cytometry at a serial dose of risperidone and at different time points, respectively. Bone transformation relevant gene serum osteocalcin (BGP), collagen 1, tumor necrosis factor-α (TNF-α), osteoprotegerin (OPG), and receptor activator of nuclear factor-κB ligand (RANKL) mRNA levels were determined by real-time PCR (qPCR). Their protein expression patterns were evaluated using western blot. The results revealed that risperidone dramatically inhibited MC3T3-E1 cell proliferation in a dose-dependent manner. It also significantly induced MC3T3-E1 cell apoptosis. TNF-α gene and protein levels were greatly enhanced after risperidone treatment. In contrast, BGP, collagen 1, OPG, and RANKL gene and protein levels were markedly downregulated. Our study indicated that risperidone suppressed MC3T3-E1 cell proliferation and induced apoptosis. It also regulated BGP gene and protein expression.
DOI: 10.6084/m9.figshare.20356416
title: Additional file 2 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 2: Table S1. Detailed information for B and K2 vitamin biosynthesis. Table S2. Relative abundance of 123 functional roles in the B and K2 vitamin biosynthesis pathways. Table S3. Distribution of vitamin biosynthesis among different phyla.
DOI: 10.6084/m9.figshare.20356416.v1
title: Additional file 2 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 2: Table S1. Detailed information for B and K2 vitamin biosynthesis. Table S2. Relative abundance of 123 functional roles in the B and K2 vitamin biosynthesis pathways. Table S3. Distribution of vitamin biosynthesis among different phyla.
DOI: 10.6084/m9.figshare.20356419
title: Additional file 3 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 3: Table S4. Combination of indispensable functional roles for B and K2 vitamin de novo biosynthesis. Table S5. Collection of 17,425 ruminant microbial genomes. Table S6. Taxonomic classification of 5318 high-quality genomes. Table S7. Genomic statistics and vitamin synthesis capabilities of 2366 VPGs. Table S8. Comparison of KOs between VPGs and other NPGs.
DOI: 10.6084/m9.figshare.20356422.v1
title: Additional file 4 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 4: Table S9. Detailed information for cobalamin biosynthesis and utilization of the 675 genomes in Fig. 4. Table S10. KOs assigned to cobalamin transporters and cobalamin-dependent enzymes.
DOI: 10.6084/m9.figshare.20356425
title: Additional file 5 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 5: Table S11. Taxonomic classification and GH family counts of the 2520 differentially enriched genomes in the CON and HG groups. Table S12. Differentially enriched GH families in the CON and HG groups.
DOI: 10.6084/m9.figshare.20356425.v1
title: Additional file 5 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 5: Table S11. Taxonomic classification and GH family counts of the 2520 differentially enriched genomes in the CON and HG groups. Table S12. Differentially enriched GH families in the CON and HG groups.
DOI: 10.6084/m9.figshare.20356419.v1
title: Additional file 3 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 3: Table S4. Combination of indispensable functional roles for B and K2 vitamin de novo biosynthesis. Table S5. Collection of 17,425 ruminant microbial genomes. Table S6. Taxonomic classification of 5318 high-quality genomes. Table S7. Genomic statistics and vitamin synthesis capabilities of 2366 VPGs. Table S8. Comparison of KOs between VPGs and other NPGs.
DOI: 10.6084/m9.figshare.20356422
title: Additional file 4 of Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants

description: Additional file 4: Table S9. Detailed information for cobalamin biosynthesis and utilization of the 675 genomes in Fig. 4. Table S10. KOs assigned to cobalamin transporters and cobalamin-dependent enzymes.
DOI: 10.5281/zenodo.10683740
title: MD Simulation of POPC cholesterol bilayers, prosECCo75 FF, different compositions, 310 K

description: prosECCo 75 paper related data
DOI: 10.5281/zenodo.10683741
title: MD Simulation of POPC cholesterol bilayers, prosECCo75 FF, different compositions, 310 K

description: prosECCo 75 paper related data
DOI: 10.6084/m9.figshare.21405061
title: Statistical Learning for Individualized Asset Allocation

description: We establish a high-dimensional statistical learning framework for individualized asset allocation. Our proposed methodology addresses continuous-action decision-making with a large number of characteristics. We develop a discretization approach to model the effect of continuous actions and allow the discretization frequency to be large and diverge with the number of observations. We estimate the value function of continuous-action using penalized regression with our proposed generalized penalties that are imposed on linear transformations of the model coefficients. We show that our proposed Discretization and Regression with generalized fOlded concaVe penalty on Effect discontinuity (DROVE) approach enjoys desirable theoretical properties and allows for statistical inference of the optimal value associated with optimal decision-making. Empirically, the proposed framework is exercised with the Health and Retirement Study data in finding individualized optimal asset allocation. The results show that our individualized optimal strategy improves the financial well-being of the population. Supplementary materials for this article are available online.