cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31238584.v1
title: Supplementary Material for: Long-acting PEGylated Growth Hormone in Children with Idiopathic Short Stature: 2-Year Results

description: Background: Idiopathic short stature (ISS) is characterized by short stature without identifiable underlying disorders. Long-acting PEGylated recombinant human growth hormone (PEG-rhGH) has emerged as a promising treatment option for ISS children. 
Objective: To evaluate the efficacy and safety of weekly PEG-rhGH in ISS children during the extension study. 
Methods: This multicenter, open-label, uncontrolled extension study (extension phase) followed the initial 52-week trial (main phase). All subjects received once-weekly PEG-rhGH at 0.2 mg/kg/wk with dose adjustment (up to 0.4 mg/kg/wk) based on height velocity (HV) and insulin-like growth factor-1 (IGF-1) standard deviation score (SDS). The primary endpoint was change in height SDS (ΔHT SDS) from baseline; secondary endpoints mainly included HV, changes in bone age/chronological age ratio, IGF-1 SDS and average annual prescribed dose. Safety was evaluated through adverse events and clinical findings. 
Results: Of 280 children enrolled in extension study, 268 completed 52-week treatment. This analysis included results up to week 104, representing 52-week extension phase following the 52-week main phase. At week 104, the least squares means (LSM) of ΔHT SDS were 1.517, 1.242 and 1.067 for PEG-rhGH 0.2/0.2 mg/kg/wk, 0.1/0.2 mg/kg/wk and 0/0.2 mg/kg/wk groups, respectively. The 0.2/0.2 mg/kg/wk group maintained significantly greater height improvements. HV was highest in the 0/0.2 mg/kg/wk group (9.158±1.334 cm/year), reflecting typical first-year catch-up growth. Mean IGF-1 SDS remained within 2SDS during 2 years. 
Conclusion: Once-weekly PEG-rhGH in children with ISS showed sustained efficacy over 2 years in all assessed height-based outcomes. Treatment remained safe and well-tolerated with no new safety signals.
DOI: 10.6084/m9.figshare.31238587
title: Supplementary Material for: When Headache Isn’t Just Headache: Two Years of Symptoms and the Value of Ophthalmic Awareness in Undiagnosed Idiopathic Intracranial Hypertension: A Case Report

description: We report a case of previously undiagnosed idiopathic intracranial hypertension (IIH) in a young woman with a two-year history of persistent headache and dizziness of unknown origin. Ophthalmic evaluation, including Optical Coherence Tomography (OCT), fundus examination and visual field testing, led to diagnosis and timely shunt placement, resulting in marked visual field recovery. This case highlights the educational value of ophthalmologic awareness, the importance of integrating ocular findings into clinical decision-making and into the assessment of chronic unexplained headache. It shows the relevance of prompt start of therapy and potential need for invasive surgery to avoid lifelong damage of the optic nerve and therefore poor visual outcome in a young population.
DOI: 10.6084/m9.figshare.31238587.v1
title: Supplementary Material for: When Headache Isn’t Just Headache: Two Years of Symptoms and the Value of Ophthalmic Awareness in Undiagnosed Idiopathic Intracranial Hypertension: A Case Report

description: We report a case of previously undiagnosed idiopathic intracranial hypertension (IIH) in a young woman with a two-year history of persistent headache and dizziness of unknown origin. Ophthalmic evaluation, including Optical Coherence Tomography (OCT), fundus examination and visual field testing, led to diagnosis and timely shunt placement, resulting in marked visual field recovery. This case highlights the educational value of ophthalmologic awareness, the importance of integrating ocular findings into clinical decision-making and into the assessment of chronic unexplained headache. It shows the relevance of prompt start of therapy and potential need for invasive surgery to avoid lifelong damage of the optic nerve and therefore poor visual outcome in a young population.
DOI: 10.6084/m9.figshare.31238590
title: Supplementary Material for: Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis

description: Background
Finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduced the risk of heart and kidney outcomes in patients with chronic kidney disease and type 2 diabetes in FIDELITY, a prespecified pooled analysis of the FIDELIO-DKD and FIGARO-DKD trials. This subanalysis explored the efficacy and safety of finerenone vs. placebo in Chinese patients. 

Methods
Patients with chronic kidney disease (urine albumin-to-creatinine ratio 30–5000 mg/g, estimated glomerular filtration rate [eGFR] ≥25 mL/min/1.73 m2) and type 2 diabetes, on optimized renin–angiotensin system inhibitors, were randomized 1:1 to finerenone or placebo. Key outcomes included a kidney composite (kidney failure, sustained ≥57% eGFR decrease from baseline over ≥4 weeks, or kidney-related death) and a cardiovascular (CV) composite (CV death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for heart failure). An additional kidney composite outcome was kidney failure, sustained ≥40% eGFR decrease from baseline over ≥4 weeks, or kidney-related death. Treatment-emergent adverse events were also assessed. 

Results
In this Chinese patient subanalysis (n = 697), finerenone reduced the risk of the ≥57% and ≥40% kidney composite outcomes (hazard ratio [HR] 0.57; 95% confidence interval [CI] 0.38–0.86; p = 0.0066 and HR 0.54; 95% CI 0.40−0.74; p &lt; 0.0001, respectively) and CV composite outcome risk vs. placebo (HR 0.82; 95% CI 0.52–1.29; p = 0.3866). Safety outcomes were similar between treatment arms. Hyperkalemia leading to treatment discontinuation was low for finerenone (2.6%) and placebo (0.9%).

Conclusion
Finerenone demonstrated kidney benefits, favorable trends on CV outcome, and a manageable safety profile in the FIDELITY Chinese subpopulation.
DOI: 10.6084/m9.figshare.31238590.v1
title: Supplementary Material for: Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis

description: Background
Finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduced the risk of heart and kidney outcomes in patients with chronic kidney disease and type 2 diabetes in FIDELITY, a prespecified pooled analysis of the FIDELIO-DKD and FIGARO-DKD trials. This subanalysis explored the efficacy and safety of finerenone vs. placebo in Chinese patients. 

Methods
Patients with chronic kidney disease (urine albumin-to-creatinine ratio 30–5000 mg/g, estimated glomerular filtration rate [eGFR] ≥25 mL/min/1.73 m2) and type 2 diabetes, on optimized renin–angiotensin system inhibitors, were randomized 1:1 to finerenone or placebo. Key outcomes included a kidney composite (kidney failure, sustained ≥57% eGFR decrease from baseline over ≥4 weeks, or kidney-related death) and a cardiovascular (CV) composite (CV death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for heart failure). An additional kidney composite outcome was kidney failure, sustained ≥40% eGFR decrease from baseline over ≥4 weeks, or kidney-related death. Treatment-emergent adverse events were also assessed. 

Results
In this Chinese patient subanalysis (n = 697), finerenone reduced the risk of the ≥57% and ≥40% kidney composite outcomes (hazard ratio [HR] 0.57; 95% confidence interval [CI] 0.38–0.86; p = 0.0066 and HR 0.54; 95% CI 0.40−0.74; p &lt; 0.0001, respectively) and CV composite outcome risk vs. placebo (HR 0.82; 95% CI 0.52–1.29; p = 0.3866). Safety outcomes were similar between treatment arms. Hyperkalemia leading to treatment discontinuation was low for finerenone (2.6%) and placebo (0.9%).

Conclusion
Finerenone demonstrated kidney benefits, favorable trends on CV outcome, and a manageable safety profile in the FIDELITY Chinese subpopulation.
DOI: 10.6084/m9.figshare.31238593
title: Supplementary Material for: A genome-wide association study of hidradenitis suppurativa from the VA's Million Veteran Program

description: Background: Data from family and twin studies as well as prior genome-wide association meta-analyses suggest that hidradenitis suppurativa (HS) has a hereditary component. 

Methods: Individuals with a diagnosis of HS (defined as at least one instance of ICD9 705.83 or ICD10 L73.2) were identified within the Million Veteran Program. Multi-population and population-specific (African, European, and Hispanic ancestries) case-control genome-wide association studies (GWAS) were performed. Lead single nucleotide polymorphisms (SNPs) were investigated in external resources providing phenome-wide associations (PheWAS), including UKBiobank, HugeAMP, and FinnGen. Demographic and clinical data for cases and controls were taken from the Corporate Data Warehouse and differences between the cases and control group were analyzed.

Results: 4,959 participants with HS were identified among 597,819 MVP participants. The multi-population GWAS identified two significant (p&lt;5x10-8) loci associated with HS, including a novel HS-related variant on chromosome 6 near HLA-DRB1 (lead variant rs679242), and confirmed a previously identified locus on chromosome 17 near SOX9 (rs55811634). The following previously identified loci achieved suggestive evidence for association (p&lt;1x10-3): , rs121908120 (2q35; WNT10A), rs10816701 (9q31.3; KLF4), rs17090189 (13q22.1; KLF5), and rs17103088 (14q24.3; TMED10). 

Conclusion: The analysis of the MVP resource for HS identified a novel signal on chromosome 6 near HLA-DRB1 and identified significant evidence and suggestive evidence for several previously reported signals for HS.
DOI: 10.6084/m9.figshare.31238593.v1
title: Supplementary Material for: A genome-wide association study of hidradenitis suppurativa from the VA's Million Veteran Program

description: Background: Data from family and twin studies as well as prior genome-wide association meta-analyses suggest that hidradenitis suppurativa (HS) has a hereditary component. 

Methods: Individuals with a diagnosis of HS (defined as at least one instance of ICD9 705.83 or ICD10 L73.2) were identified within the Million Veteran Program. Multi-population and population-specific (African, European, and Hispanic ancestries) case-control genome-wide association studies (GWAS) were performed. Lead single nucleotide polymorphisms (SNPs) were investigated in external resources providing phenome-wide associations (PheWAS), including UKBiobank, HugeAMP, and FinnGen. Demographic and clinical data for cases and controls were taken from the Corporate Data Warehouse and differences between the cases and control group were analyzed.

Results: 4,959 participants with HS were identified among 597,819 MVP participants. The multi-population GWAS identified two significant (p&lt;5x10-8) loci associated with HS, including a novel HS-related variant on chromosome 6 near HLA-DRB1 (lead variant rs679242), and confirmed a previously identified locus on chromosome 17 near SOX9 (rs55811634). The following previously identified loci achieved suggestive evidence for association (p&lt;1x10-3): , rs121908120 (2q35; WNT10A), rs10816701 (9q31.3; KLF4), rs17090189 (13q22.1; KLF5), and rs17103088 (14q24.3; TMED10). 

Conclusion: The analysis of the MVP resource for HS identified a novel signal on chromosome 6 near HLA-DRB1 and identified significant evidence and suggestive evidence for several previously reported signals for HS.
DOI: 10.15468/dl.akwyyy
title: Occurrence Download

description: A dataset containing 9693 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Senecio erucifolius, Senecio erucifolius, Senecio erucifolius, Jacobaea erucifolia)",
 "Year is greater than or equal to 1900",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 9693 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009023-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8kcj27
title: Occurrence Download

description: A dataset containing 19425 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Senecio jacobaea, Senecio jacobaea, Senecio jacobaea, Senecio jacobaea, Senecio jacobaea, Senecio jacobaea, Jacobaea vulgaris, Jacobaea vulgaris, Jacobaea vulgaris)",
 "Year is greater than or equal to 1900",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 19425 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009024-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s38qm9
title: Occurrence Download

description: A dataset containing 780 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Juglans mollis"
 ]
}

 The dataset includes 780 records from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009027-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ws779w
title: Occurrence Download

description: A dataset containing 283 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Myrtastrum rufopunctatum",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 283 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009026-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cub4yw
title: Occurrence Download

description: A dataset containing 31219 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Senecio ovatus, Senecio ovatus, Senecio ovatus, Senecio ovatus, Senecio fuchsii, Senecio fuchsii, Senecio nemorensis, Senecio nemorensis)",
 "Year is greater than or equal to 1900",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 31219 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009025-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.31238245
title: Multi‑omics time‑course dataset of salt adaptation in mung bean (Vigna radiata)

description: Multi‑omics time‑course dataset of salt adaptation in mung bean (Vigna radiata): RNA‑Seq, ATAC‑Seq and methylome profiles with pre‑acclimation and direct‑stress treatments
DOI: 10.6084/m9.figshare.31238245.v1
title: Multi‑omics time‑course dataset of salt adaptation in mung bean (Vigna radiata)

description: Multi‑omics time‑course dataset of salt adaptation in mung bean (Vigna radiata): RNA‑Seq, ATAC‑Seq and methylome profiles with pre‑acclimation and direct‑stress treatments
DOI: 10.15468/dl.4ebupv
title: Occurrence Download

description: A dataset containing 5332717 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Indonesia",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 5332717 records from 2962 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008973-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5qq2vp
title: Occurrence Download

description: A dataset containing 1512 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Vieja melanura (Günther, 1862)"
 ]
}

 The dataset includes 1512 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075138-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.shw62k
title: Occurrence Download

description: A dataset containing 21319 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Clitellata",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Geometry POLYGON ((-25.03991 31.75, 41.65954 31.75, 41.65954 71.53037, -25.03991 71.53037, -25.03991 31.75))",
 "Year is greater than or equal to 1972",
 "Year is less than or equal to 1982"
 ]
}

 The dataset includes 21319 records from 72 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0261797-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pfyej6
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Obliquogobius fulvostriatus Chen, Jaafar & Shao, 2012"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075173-220831081235567/datasets/export for details.
DOI: 10.15468/dl.2bjm33
title: Occurrence Download

description: A dataset listing the 4466 species recorded in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Bivalvia",
 "Country is United States of America",
 {
 "or" : [
 "StateProvince is Arkansas",
 "StateProvince is Arizona",
 "StateProvince is Colorado",
 "StateProvince is Indiana",
 "StateProvince is Kansas",
 "StateProvince is Kentucky",
 "StateProvince is Louisiana",
 "StateProvince is Michigan",
 "StateProvince is Nebraska",
 "StateProvince is North Dakota",
 "StateProvince is Ohio",
 "StateProvince is Oklahoma",
 "StateProvince is South Dakota",
 "StateProvince is Tennessee",
 "StateProvince is Texas"
 ]
 },
 "HasGeospatialIssue is false"
 ]
}

 The dataset's 4466 records were derived from 104 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0261832-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fhvtw2
title: Occurrence Download

description: A dataset containing 6761 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Chile",
 "Geometry POLYGON((-77.05495 -53.95483,-64.57059 -56.31513,-66.87154 -18.00516,-73.30182 -18.00516,-77.05495 -53.95483))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Chroicocephalus serranus (Tschudi, 1844)",
 "Year 2000-2022"
 ]
}

 The dataset includes 6761 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075156-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7vpw8w
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Guepinia iberis DC."
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049498-220831081235567/datasets/export for details.
DOI: 10.15468/dl.cefguk
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Guepinia nudicaulis (L.) Bastard"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049500-220831081235567/datasets/export for details.
DOI: 10.15468/dl.chra6y
title: Occurrence Download

description: A dataset containing 26528 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Crepis foetida L.",
 "HasCoordinate is true"
 ]
}

 The dataset includes 26528 records from 282 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030337-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tfafn5
title: Occurrence Download

description: A dataset containing 63 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-118.1989291000000009 33.8263457999999986, -118.1989291000000009 33.8278500400000013, -118.1989291000000009 33.8289364399999997, -118.1989291000000009 33.8306913899999984, -118.1989291000000009 33.8326970399999993, -118.1989291000000009 33.8347027000000011, -118.1973449999999985 33.8347027000000011, -118.1958444800000052 33.8347027000000011, -118.1935936900000002 33.8347027000000011, -118.1910094499999957 33.8347027000000011, -118.1891754699999950 33.8347027000000011, -118.1877580999999964 33.8347027000000011, -118.1877580999999964 33.8337834399999977, -118.1877580999999964 33.8323627700000031, -118.1877580999999964 33.8306913899999984, -118.1877580999999964 33.8295214199999990, -118.1877580999999964 33.8282678899999993, -118.1877580999999964 33.8263457999999986, -118.1889253800000006 33.8263457999999986, -118.1908427200000062 33.8263457999999986, -118.1920931599999989 33.8263457999999986, -118.1935103299999952 33.8263457999999986, -118.1951775800000064 33.8263457999999986, -118.1978451800000016 33.8263457999999986, -118.1989291000000009 33.8263457999999986))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 63 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075175-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hbr26y
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pycnoplinthopsis bhutanica Jafri"
 ]
}

 The dataset includes 27 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049501-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cuxenw
title: Occurrence Download

description: A dataset containing 179 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Crepis froelichiana DC.",
 "HasCoordinate is true"
 ]
}

 The dataset includes 179 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030346-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.