cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17129509.v1
title: Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers

description: Acquired chemotherapy resistance is one of the main culprits in the relapse of breast cancer. But the underlying mechanism of chemotherapy resistance remains elusive. Here, we demonstrate that a small adaptor protein, SH3BGRL, is not only elevated in the majority of breast cancer patients but also has relevance with the relapse and poor prognosis of breast cancer patients. Functionally, SH3BGRL upregulation enhances the chemoresistance of breast cancer cells to the first-line doxorubicin treatment through macroautophagic/autophagic protection. Mechanistically, SH3BGRL can unexpectedly bind to ribosomal subunits to enhance PIK3C3 translation efficiency and sustain ATG12 stability. Therefore, inhibition of autophagy or silence of PIK3C3 or ATG12 can effectively block the driving effect of SH3BGRL on doxorubicin resistance of breast cancer cells in vitro and in vivo. We also validate that SH3BGRL expression is positively correlated with that of PIK3C3 or ATG12, as well as the constitutive occurrence of autophagy in clinical breast cancer tissues. Taken together, our data reveal that SH3BGRL upregulation would be a key driver to the acquired chemotherapy resistance through autophagy enhancement in breast cancer while targeting SH3BGRL could be a potential therapeutic strategy against breast cancer. <b>Abbreviations:</b> ABCs: ATP-binding cassette transporters; Act D: actinomycin D; ACTB/β-actin: actin beta; ATG: autophagy-related; Baf A<sub>1</sub>: bafilomycin A<sub>1</sub>; CASP3: caspase 3; CHX: cycloheximide; CQ: chloroquine; Dox: doxorubicin; FBS: fetal bovine serum; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GEO: gene expression omnibus; GFP: green fluorescent protein; G6PD: glucose-6-phosphate dehydrogenase; GSEA: gene set enrichment analysis; IHC: immunochemistry; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; 3-MA: 3-methyladenine; mRNA: messenger RNA; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; SH3BGRL: SH3 domain binding glutamate-rich protein-like; SQSTM1/p62: sequestosome 1; ULK1: unc-51 like autophagy activating kinase 1
DOI: 10.6084/m9.figshare.13983900
title: A COMPREHENSIVE ASSESSMENT OF CO-OCCURRING BIRTH DEFECTS AMONG INFANTS WITH NON-SYNDROMIC ANOPHTHALMIA OR MICROPHTHALMIA

description: Infants with anophthalmia or microphthalmia frequently have co-occurring birth defects. Nonetheless, there have been few investigations of birth defect patterns among these children. Such studies may identify novel multiple malformation syndromes, which could inform future research into the developmental processes that lead to anophthalmia/microphthalmia and assist physicians in determining whether further testing is appropriate. This study includes cases with anophthalmia/microphthalmia identified by the Texas Birth Defects Registry from 1999 to 2014 without clinical or chromosomal diagnoses of recognized syndromes. We calculated adjusted observed-to-expected ratios for two – through five-way birth defect combinations involving anophthalmia/microphthalmia to estimate whether these combinations co-occur more often than would be expected if they were independent. We report combinations observed in ≥5 cases. We identified 653 eligible cases with anophthalmia/microphthalmia (514 [79%] with co-occurring birth defects), and 111 birth defect combinations, of which 44 were two-way combinations, 61 were three-way combinations, six were four-way combinations and none were five-way combinations. Combinations with the largest observed-to-expected ratios were those involving central nervous system (CNS) defects, head/neck defects, and orofacial clefts. We also observed multiple combinations involving cardiovascular and musculoskeletal defects. Consistent with previous reports, we observed that a large proportion of children diagnosed with anophthalmia/microphthalmia have co-occurring birth defects. While some of these defects may be part of a sequence involving anophthalmia/microphthalmia (e.g., CNS defects), other combinations could point to as yet undescribed susceptibility patterns (e.g., musculoskeletal defects). Data from population-based birth defect registries may be useful for accelerating the discovery of previously uncharacterized malformation syndromes.
DOI: 10.6084/m9.figshare.13983900.v1
title: A COMPREHENSIVE ASSESSMENT OF CO-OCCURRING BIRTH DEFECTS AMONG INFANTS WITH NON-SYNDROMIC ANOPHTHALMIA OR MICROPHTHALMIA

description: Infants with anophthalmia or microphthalmia frequently have co-occurring birth defects. Nonetheless, there have been few investigations of birth defect patterns among these children. Such studies may identify novel multiple malformation syndromes, which could inform future research into the developmental processes that lead to anophthalmia/microphthalmia and assist physicians in determining whether further testing is appropriate. This study includes cases with anophthalmia/microphthalmia identified by the Texas Birth Defects Registry from 1999 to 2014 without clinical or chromosomal diagnoses of recognized syndromes. We calculated adjusted observed-to-expected ratios for two – through five-way birth defect combinations involving anophthalmia/microphthalmia to estimate whether these combinations co-occur more often than would be expected if they were independent. We report combinations observed in ≥5 cases. We identified 653 eligible cases with anophthalmia/microphthalmia (514 [79%] with co-occurring birth defects), and 111 birth defect combinations, of which 44 were two-way combinations, 61 were three-way combinations, six were four-way combinations and none were five-way combinations. Combinations with the largest observed-to-expected ratios were those involving central nervous system (CNS) defects, head/neck defects, and orofacial clefts. We also observed multiple combinations involving cardiovascular and musculoskeletal defects. Consistent with previous reports, we observed that a large proportion of children diagnosed with anophthalmia/microphthalmia have co-occurring birth defects. While some of these defects may be part of a sequence involving anophthalmia/microphthalmia (e.g., CNS defects), other combinations could point to as yet undescribed susceptibility patterns (e.g., musculoskeletal defects). Data from population-based birth defect registries may be useful for accelerating the discovery of previously uncharacterized malformation syndromes.
DOI: 10.6084/m9.figshare.25245487
title: cysH.pdb predicted via 'ColabFold'

description: cysH.pdb predicted via 'ColabFold'
DOI: 10.6084/m9.figshare.25245487.v1
title: cysH.pdb predicted via 'ColabFold'

description: cysH.pdb predicted via 'ColabFold'
DOI: 10.57967/hf/1793
title: MonoDialogic
DOI: 10.6084/m9.figshare.12935365.v1
title: Additional file 4 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 4: Table S1. Information on 14 grain size genes for marker development.
DOI: 10.6084/m9.figshare.12935368
title: Additional file 5 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 5: Table S2. Origin and population structure of the Rice Diversity Panel 1 accessions included in the study based on McCouch et al. (2016).
DOI: 10.6084/m9.figshare.12935368.v1
title: Additional file 5 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 5: Table S2. Origin and population structure of the Rice Diversity Panel 1 accessions included in the study based on McCouch et al. (2016).
DOI: 10.6084/m9.figshare.12935371
title: Additional file 6 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 6: Table S3. Phenotypic data for the Rice Diversity Panel 1 accessions grown at the Songjiang Experiment Station near Shanghai and the Lingshui Experiment Station near Hainan, China.
DOI: 10.6084/m9.figshare.12935371.v1
title: Additional file 6 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 6: Table S3. Phenotypic data for the Rice Diversity Panel 1 accessions grown at the Songjiang Experiment Station near Shanghai and the Lingshui Experiment Station near Hainan, China.
DOI: 10.6084/m9.figshare.12935374
title: Additional file 7 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 7: Table S4. Allele type of the Rice Diversity Panel 1 accessions genotyped by 20 functional markers.
DOI: 10.6084/m9.figshare.12935374.v1
title: Additional file 7 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 7: Table S4. Allele type of the Rice Diversity Panel 1 accessions genotyped by 20 functional markers.
DOI: 10.6084/m9.figshare.12935428
title: Additional file 1 of OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway

description: Additional file 1. Additional file.
DOI: 10.6084/m9.figshare.12935428.v1
title: Additional file 1 of OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway

description: Additional file 1. Additional file.
DOI: 10.6084/m9.figshare.12935377
title: Additional file 8 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 8: Table S5. Information on 123 markers used for QTL analysis of the YYP1/NIP F2 population.
DOI: 10.6084/m9.figshare.12935377.v1
title: Additional file 8 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 8: Table S5. Information on 123 markers used for QTL analysis of the YYP1/NIP F2 population.
DOI: 10.6084/m9.figshare.12935380
title: Additional file 9 of Grain Size Selection Using Novel Functional Markers Targeting 14 Genes in Rice

description: Additional file 9: Table S6. Effects and locations of the QTLs identified from the YYP1/NIP F2 population.
DOI: 10.6084/m9.figshare.26876749
title: 2nd Delphi Round Perception Questionnaire -EI CVP PD-

description: Data from experts in the 2nd Delphi Round for the analysis of the content validity evidence of the Early Care Specialists' Perception Questionnaire on the Incidence of Virtual Communities in Professional Development. The experts evaluate the items by calculating three criteria: Relevance, accuracy and pertinence. The items are evaluated with a Likert scale 1 “not at all”; 2 “a little”; somewhat, 3 “quite a bit”; 4 “a lot”) for relevance and accuracy, while the criterion of relevance was evaluated dichotomously (yes or no).
DOI: 10.6084/m9.figshare.26876749.v1
title: 2nd Delphi Round Perception Questionnaire -EI CVP PD-

description: Data from experts in the 2nd Delphi Round for the analysis of the content validity evidence of the Early Care Specialists' Perception Questionnaire on the Incidence of Virtual Communities in Professional Development. The experts evaluate the items by calculating three criteria: Relevance, accuracy and pertinence. The items are evaluated with a Likert scale 1 “not at all”; 2 “a little”; somewhat, 3 “quite a bit”; 4 “a lot”) for relevance and accuracy, while the criterion of relevance was evaluated dichotomously (yes or no).
DOI: 10.6069/uwlswd.tam3-2476
title: All: date 2
DOI: 10.6069/uwlswd.py0f-0s95
title: All: date 1
DOI: 10.6069/uwlswd.gabh-vf67
title: All: date entered on file
DOI: 10.6069/uwlswd.b5wb-fr38
title: All: language
DOI: 10.6069/uwlswd.h15g-zv41
title: All: modified record
DOI: 10.6069/uwlswd.exen-6x37
title: All: place of publication production execution
DOI: 10.6069/uwlswd.tsh7-5175
title: All: cataloging source
DOI: 10.6069/uwlswd.m0xp-h565
title: Books: index
DOI: 10.15468/dl.yc4ky2
title: Occurrence Download

description: A dataset containing 169 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lipotriches tridentata (Smith, 1875)"
 ]
}

 The dataset includes 169 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0108371-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6069/uwlswd.6mz0-ta86
title: Continuing: conference publication
DOI: 10.6069/uwlswd.2h4d-g549
title: Maps: index
DOI: 10.6069/uwlswd.tq9s-1157
title: Books: festschrift
DOI: 10.6069/uwlswd.t1gh-8294
title: Books: conference publication
DOI: 10.15468/dl.4ssgxz
title: Occurrence Download

description: A dataset containing 2227 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is IRAD Cameroon insect collection"
 ]
}

 The dataset includes 2227 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0108372-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.10687143
title: Dataset from: Relative Sea-Level Sensitivity in the Eurasian Region to Earth and Ice-Sheet Model Uncertainty During the Last Interglacial
DOI: 10.5281/zenodo.10687144
title: Dataset from: Relative Sea-Level Sensitivity in the Eurasian Region to Earth and Ice-Sheet Model Uncertainty During the Last Interglacial
DOI: 10.6073/pasta/aff1a5692ef0b3cf7b8ed9b1b6b06e7d
title: Fish Facilities Salvage Data 1993-2023

description: The Bureau of Reclamation’s (Reclamation) Central Valley Project (CVP) and the California Department of Water Resource’s (DWR) State Water Project (SWP) deliver millions of acre-feet of water annually for agricultural, municipal, industrial, and environmental needs in California from the Sacramento-San Joaquin River Delta (Delta) through the C.W. “Bill” Jones Pumping Plant (JPP) and Banks Pumping Plant. Since 1957, a Reclamation operated fish salvage facility, the Tracy Fish Collection Facility (TFCF), is located upstream of the JPP and functions to salvage fish entrained in exported water (Bates and Vinsonhaler 1957). Additionally, the John E. Skinner Delta Fish Protective Facility (SDFPF) was added by the California Department of Water Resources in 1968 to salvage fishes diverted by the SWP. The salvage process involves fish collection, counting, handling and transportation back to the Delta. To prevent fish loss, CVP and SWP fish facilities were constructed at Old river, where fish are diverted to the fish facilities for counting and reporting. After counting, the fish are collected in storage tanks and taken to several release locations in the Delta via fish-haul tank trucks. Millions of fishes from 69 species are salvaged through this process by the two fish facilities. Data collected includes species collected, fish lengths, water flow, export amounts, and water quality. Fishes listed (Endangered Species Act (ESA) or California Endangered Species Act (CESA)) were Chinook Salmon, Delta Smelt, steelhead trout, Longfin Smelt, and Green Sturgeon. The California Department of Fish and Wildlife monitors fish salvage and manages the data collected from the fish facilities in addition to data collected and managed by DWR and Reclamation.
DOI: 10.15468/dl.tmm84c
title: Occurrence Download

description: A dataset containing 12 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoradendron applanatum Kuijt"
 ]
}

 The dataset includes 12 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0108373-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zvgq3y
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phoradendron apurense Rizzini"
 ]
}

 The dataset includes 10 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0108374-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4aspgs
title: Occurrence Download

description: A dataset containing 158985282 species occurrences available in GBIF matching the query:
{
 "Country" : [
 "is United Kingdom of Great Britain and Northern Ireland"
 ]
}

 The dataset includes 158985282 records from 3214 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0108351-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.16485033.v1
title: 2008-03-18 11-21 Lake Kainui (Lake D)

description: A CTD cast on Lake Kainui<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2008-03-18<br><br><b>End date:</b> 2008-03-18<br><br><b>Lake:</b> Lake Kainui<br><br><b>Region:</b> Waikato<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.48370/ofd/l3eihn
title: Phanerochaete velutina (DC.) P. Karst., 2271

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.16485093.v1
title: 2008-03-18 11-29 Lake Kainui (Lake D)

description: A CTD cast on Lake Kainui<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2008-03-18<br><br><b>End date:</b> 2008-03-18<br><br><b>Lake:</b> Lake Kainui<br><br><b>Region:</b> Waikato<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.16485135.v1
title: 2008-03-18 11-37 Lake Kainui (Lake D)

description: A CTD cast on Lake Kainui<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2008-03-18<br><br><b>End date:</b> 2008-03-18<br><br><b>Lake:</b> Lake Kainui<br><br><b>Region:</b> Waikato<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.16485180.v1
title: 2008-03-18 11-45 Lake Kainui (Lake D)

description: A CTD cast on Lake Kainui<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2008-03-18<br><br><b>End date:</b> 2008-03-18<br><br><b>Lake:</b> Lake Kainui<br><br><b>Region:</b> Waikato<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.
DOI: 10.6084/m9.figshare.16485225.v1
title: 2008-03-26 12-10 Lake Kainui (Lake D)

description: A CTD cast on Lake Kainui<br><br><b>Quality control:</b> Calibration; Model; Sensor height (m)<br><br><b>Type of waterbody:</b> Lake<br><br><b>Variables:</b> Beam Transmission; Chlorophyll Fluorescence; Conductivity; Dissolved Oxygen Concentration; Dissolved Oxygen Saturation; Photosynthetically Active Radiation; Salinity; Specific Conductance; Water Temperature<br><br><b>Start date:</b> 2008-03-26<br><br><b>End date:</b> 2008-03-26<br><br><b>Lake:</b> Lake Kainui<br><br><b>Region:</b> Waikato<br><br>This dataset was originally hosted in the LERNZdb freshwater data repository that was developed as part of the Lake Ecosystem Restoration New Zealand (LERNZ) project run by the Environmental Research Institute at the University of Waikato, New Zealand. <br><br>In retrieving LERNZdb material you agree that you rely on the data at your own risk; the University of Waikato offers no warranty or representation that the data is fit for any particular purpose, or free from defects, and will not be liable for any losses or damages whatsoever including any indirect, special, incidental or consequential damages incurred by you arising out of the use of the database or in reliance on the data retrieved. You agree that data is not of a kind ordinarily supplied for personal or domestic purposes, and that the Consumer Guarantees Act 1993 does not apply.