cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29635924.v1
title: Perceptions of research experience during internal medicine training: insights from a national survey

description: There is limited insights into how internal medicine (IM) residents perceive research. This study aimed to assess residents’ perceptions across five domains: well-being, research competence, research support, effect on training, and research quality. In 2022, a survey instrument was developed to assess residents’ perceptions of research across five domains. All IM programs listed in Fellowship and Residency Electronic Interactive Database (FREIDA) were contacted by email, and residents were invited to participate. A total of 530 residents from 67 IM programs completed our survey. Just over 80% of respondents had participated in research during residency. Residents were dissatisfied with research opportunities and infrastructure but viewed research funding more positively. Negative views were held regarding the impact of publication pressure on well-being and the quality of research produced. Publication pressure was perceived to compromise clinical work and limit career paths. Some residents acknowledged that research enriched their training. Residents who had already matched into a fellowship program reported higher research competency and better impressions of the impact of research on their medical training compared to those who had not yet or did not plan to match into a fellowship. Residents who planned to prioritize research in their future careers held positive perceptions of research across multiple domains. This study provides valuable insights into the impact of publication pressure on IM residents. The findings suggest a need to realign expectations for research productivity or target interventions to better support research for all residents, regardless of track or career goals.
DOI: 10.6084/m9.figshare.29755571
title: Trends and levels of the global, regional, and national burden of injuries from 1990 to 2021: findings from the global burden of disease study 2021

description: Injuries remain a major global public health challenge. This study aimed to analyze the global, regional, and national burden of injuries from 1990 to 2021 and project future trends to 2046, addressing a gap in long-term trend analyses and projections accounting for demographic shifts. We conducted an observational analysis using data from the Global Burden of Disease (GBD) Study 2021, covering 204 countries and territories. We extracted data on injury incidence, prevalence, mortality, and disability-adjusted life years (DALYs). Age-standardized rates (ASRs) were calculated. Temporal trends (1990–2021) were assessed using estimated annual percentage change (EAPC). Future burden (2022–2046) was projected using statistical modeling. Globally, while absolute numbers of injury incidence, prevalence, deaths, and DALYs increased from 1990 to 2021, all corresponding ASRs declined significantly (EAPC: incidence – 0.96%, prevalence – 0.73%, mortality – 1.55%, and DALYs – 1.75%). Males consistently bore a greater burden than females (mortality ratio male:female = 2.41). Marked disparities existed: mortality rates in low Socio-demographic Index (SDI) regions were 2.5 times higher than in high SDI regions. Afghanistan, the Central African Republic, and Lesotho had the highest national mortality rates; Singapore, Spain, and Italy the lowest. Projections indicate rising absolute cases but declining ASRs through 2046. Despite declining ASRs, the increasing absolute injury burden necessitates intensified prevention efforts. Targeted interventions are crucial to address persistent geographic, demographic (especially males), and socioeconomic (low SDI regions) disparities.
DOI: 10.6084/m9.figshare.29755571.v1
title: Trends and levels of the global, regional, and national burden of injuries from 1990 to 2021: findings from the global burden of disease study 2021

description: Injuries remain a major global public health challenge. This study aimed to analyze the global, regional, and national burden of injuries from 1990 to 2021 and project future trends to 2046, addressing a gap in long-term trend analyses and projections accounting for demographic shifts. We conducted an observational analysis using data from the Global Burden of Disease (GBD) Study 2021, covering 204 countries and territories. We extracted data on injury incidence, prevalence, mortality, and disability-adjusted life years (DALYs). Age-standardized rates (ASRs) were calculated. Temporal trends (1990–2021) were assessed using estimated annual percentage change (EAPC). Future burden (2022–2046) was projected using statistical modeling. Globally, while absolute numbers of injury incidence, prevalence, deaths, and DALYs increased from 1990 to 2021, all corresponding ASRs declined significantly (EAPC: incidence – 0.96%, prevalence – 0.73%, mortality – 1.55%, and DALYs – 1.75%). Males consistently bore a greater burden than females (mortality ratio male:female = 2.41). Marked disparities existed: mortality rates in low Socio-demographic Index (SDI) regions were 2.5 times higher than in high SDI regions. Afghanistan, the Central African Republic, and Lesotho had the highest national mortality rates; Singapore, Spain, and Italy the lowest. Projections indicate rising absolute cases but declining ASRs through 2046. Despite declining ASRs, the increasing absolute injury burden necessitates intensified prevention efforts. Targeted interventions are crucial to address persistent geographic, demographic (especially males), and socioeconomic (low SDI regions) disparities.
DOI: 10.6084/m9.figshare.29898429
title: Impact of previous cesarean delivery on reproductive outcomes of assisted reproductive technology: a Bayesian network meta-analysis

description: To systematically review the impact of vaginal delivery (VD), cesarean scar (CS), cesarean scar disorder (CSD) and intra-cavitary fluid (ICF) on the reproductive outcomes of women involving assisted reproductive technology (ART) based on Bayesian network meta-analysis. Six databases were searched from the inception to October 16, 2024. Primary outcomes were clinical pregnancy rate and live birth rate. Secondary outcomes included positive human chorionic gonadotropin (hCG) test rate, miscarriage rate, ectopic pregnancy rate, and severe adverse pregnancy outcomes. Extracted study data were analyzed by pairwise and network meta-analysis using R software and Stata. This study revealed that CS, CSD and ICF significantly reduced clinical pregnancy rate (CS vs VD: RR = 0.88, 95% CI 0.78-0.99, <i>p</i> &lt; 0.05; CSD vs VD: RR = 0.72, 95% CI 0.59-0.86, <i>p</i> &lt; 0.05; ICF vs VD: RR = 0.63, 95% CI 0.46-0.82, <i>p</i> &lt; 0.05), and live birth rate (CS vs VD: RR = 0.86, 95% CI 0.76-0.97, <i>p</i> &lt; 0.05; CSD vs VD: RR = 0.65, 95% CI 0.52-0.79, <i>p</i> &lt; 0.05; ICF vs VD: RR = 0.61, 95% CI 0.43-0.82, <i>p</i> &lt; 0.05) compared to VD. Furthermore, CSD had a lower live birth rate than CS (RR = 0.75, 95% CI 0.59-0.95, <i>p</i> &lt; 0.05); ICF decreased both clinical pregnancy rate (RR = 0.72, 95% CI 0.51-0.95, <i>p</i> &lt; 0.05) and live birth rate (RR = 0.71, 95% CI 0.49-0.97, <i>p</i> &lt; 0.05) compared with CS. ICF, CSD, and CS all significantly reduce clinical pregnancy rate and live birth rate in women with ART. CSD and ICF had much lower live birth rate than CS. Notably, ICF was a prominent risk factor for these adverse reproductive outcomes. Registered with PROSPERO on October 19, 2024, CRD42024603479.
DOI: 10.6084/m9.figshare.29898429.v1
title: Impact of previous cesarean delivery on reproductive outcomes of assisted reproductive technology: a Bayesian network meta-analysis

description: To systematically review the impact of vaginal delivery (VD), cesarean scar (CS), cesarean scar disorder (CSD) and intra-cavitary fluid (ICF) on the reproductive outcomes of women involving assisted reproductive technology (ART) based on Bayesian network meta-analysis. Six databases were searched from the inception to October 16, 2024. Primary outcomes were clinical pregnancy rate and live birth rate. Secondary outcomes included positive human chorionic gonadotropin (hCG) test rate, miscarriage rate, ectopic pregnancy rate, and severe adverse pregnancy outcomes. Extracted study data were analyzed by pairwise and network meta-analysis using R software and Stata. This study revealed that CS, CSD and ICF significantly reduced clinical pregnancy rate (CS vs VD: RR = 0.88, 95% CI 0.78-0.99, <i>p</i> &lt; 0.05; CSD vs VD: RR = 0.72, 95% CI 0.59-0.86, <i>p</i> &lt; 0.05; ICF vs VD: RR = 0.63, 95% CI 0.46-0.82, <i>p</i> &lt; 0.05), and live birth rate (CS vs VD: RR = 0.86, 95% CI 0.76-0.97, <i>p</i> &lt; 0.05; CSD vs VD: RR = 0.65, 95% CI 0.52-0.79, <i>p</i> &lt; 0.05; ICF vs VD: RR = 0.61, 95% CI 0.43-0.82, <i>p</i> &lt; 0.05) compared to VD. Furthermore, CSD had a lower live birth rate than CS (RR = 0.75, 95% CI 0.59-0.95, <i>p</i> &lt; 0.05); ICF decreased both clinical pregnancy rate (RR = 0.72, 95% CI 0.51-0.95, <i>p</i> &lt; 0.05) and live birth rate (RR = 0.71, 95% CI 0.49-0.97, <i>p</i> &lt; 0.05) compared with CS. ICF, CSD, and CS all significantly reduce clinical pregnancy rate and live birth rate in women with ART. CSD and ICF had much lower live birth rate than CS. Notably, ICF was a prominent risk factor for these adverse reproductive outcomes. Registered with PROSPERO on October 19, 2024, CRD42024603479.
DOI: 10.6084/m9.figshare.28925767
title: Public perspectives on tick bite exposure, healthcare visits and associated allergies in iberia

description: Tick bites and tick-borne diseases (TBDs) are a worldwide concern, with growing evidence of an ongoing spread and emergence of new cases. This study applied a participatory citizen science across Spain and Portugal to gather public perspectives on the impact of tick bites, the presence of TBDs and a potential connection with the α-Gal syndrome (AGS). Data collected from the questionnaire (380 participants) was geographically represented using QGIS Geographic Information System and fitted into multiple generalized linear models (GLMs). Statistical analysis identified factors influencing the occurrence of local skin reactions post-tick bite, AGS-compatible symptoms and visits to health centers following tick exposure. Results showed that the probability of developing localized skin reactions to tick bites rises with increasing age (<i>χ</i><sup>2</sup> = 0.006, <i>p</i> &lt; 0.05), the occurrence of multiple bites (<i>χ</i><sup>2</sup> = 0.006, <i>p</i> = 0.063) and among individuals bitten in the center-north part of the peninsula (<i>χ</i><sup>2</sup> = 0.006, <i>p</i> = 0.058). Seeking medical care following tick bite was reported by 21.6% of respondents, being more common in first-time bite cases (<i>χ</i><sup>2</sup> = 0.002, p &lt; 0.01), men (<i>χ</i><sup>2</sup> = 0.002, <i>p</i> &lt; 0.01) or individuals presenting localized skin symptoms (<i>χ</i><sup>2</sup> = 0.002, <i>p</i> &lt; 0.05). Although 38 inquiries (10.0%) showed signs of AGS, only 3 had received a formal diagnosis, with the odds of developing this disease marginally rising with advancing age (<i>χ</i><sup>2</sup> = 0.215, <i>p</i> = 0.066). This study provides valuable insights that should be considered to improve TBDs surveillance and diagnostic strategies, as well as developing preventive measures to reduce tick bite exposure and TBD cases. <b>Key Messages</b>Developing local skin reactions to tick bites increases with age, multiple bites and in individuals bitten in central-northern Iberia.Seeking medical care following a tick bite is more common in first-time bite cases, men or individuals with local skin symptoms.Although 38 inquiries (10.0%) showed signs of AGS, only 3 were formally diagnosed, with risk increasing with age. Developing local skin reactions to tick bites increases with age, multiple bites and in individuals bitten in central-northern Iberia. Seeking medical care following a tick bite is more common in first-time bite cases, men or individuals with local skin symptoms. Although 38 inquiries (10.0%) showed signs of AGS, only 3 were formally diagnosed, with risk increasing with age.
DOI: 10.6084/m9.figshare.28925767.v1
title: Public perspectives on tick bite exposure, healthcare visits and associated allergies in iberia

description: Tick bites and tick-borne diseases (TBDs) are a worldwide concern, with growing evidence of an ongoing spread and emergence of new cases. This study applied a participatory citizen science across Spain and Portugal to gather public perspectives on the impact of tick bites, the presence of TBDs and a potential connection with the α-Gal syndrome (AGS). Data collected from the questionnaire (380 participants) was geographically represented using QGIS Geographic Information System and fitted into multiple generalized linear models (GLMs). Statistical analysis identified factors influencing the occurrence of local skin reactions post-tick bite, AGS-compatible symptoms and visits to health centers following tick exposure. Results showed that the probability of developing localized skin reactions to tick bites rises with increasing age (<i>χ</i><sup>2</sup> = 0.006, <i>p</i> &lt; 0.05), the occurrence of multiple bites (<i>χ</i><sup>2</sup> = 0.006, <i>p</i> = 0.063) and among individuals bitten in the center-north part of the peninsula (<i>χ</i><sup>2</sup> = 0.006, <i>p</i> = 0.058). Seeking medical care following tick bite was reported by 21.6% of respondents, being more common in first-time bite cases (<i>χ</i><sup>2</sup> = 0.002, p &lt; 0.01), men (<i>χ</i><sup>2</sup> = 0.002, <i>p</i> &lt; 0.01) or individuals presenting localized skin symptoms (<i>χ</i><sup>2</sup> = 0.002, <i>p</i> &lt; 0.05). Although 38 inquiries (10.0%) showed signs of AGS, only 3 had received a formal diagnosis, with the odds of developing this disease marginally rising with advancing age (<i>χ</i><sup>2</sup> = 0.215, <i>p</i> = 0.066). This study provides valuable insights that should be considered to improve TBDs surveillance and diagnostic strategies, as well as developing preventive measures to reduce tick bite exposure and TBD cases. <b>Key Messages</b>Developing local skin reactions to tick bites increases with age, multiple bites and in individuals bitten in central-northern Iberia.Seeking medical care following a tick bite is more common in first-time bite cases, men or individuals with local skin symptoms.Although 38 inquiries (10.0%) showed signs of AGS, only 3 were formally diagnosed, with risk increasing with age. Developing local skin reactions to tick bites increases with age, multiple bites and in individuals bitten in central-northern Iberia. Seeking medical care following a tick bite is more common in first-time bite cases, men or individuals with local skin symptoms. Although 38 inquiries (10.0%) showed signs of AGS, only 3 were formally diagnosed, with risk increasing with age.
DOI: 10.6084/m9.figshare.28054754
title: Maternal group B <i>Streptococcus</i> decreases infant length and alters the early-life microbiome: a prospective cohort study

description: Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota’s importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics. We recruited and classified 453 pregnant women from southern China into GBS or healthy groups based on GBS vaginal colonization. Their infants were categorized as GBS-exposed or GBS-unexposed groups. We comprehensively analyzed infant growth, gut microbiota, and metabolites during early life, along with maternal vaginal microbiota during pregnancy, using 16S rDNA sequencing and targeted metabolomics. GBS-exposed infants exhibited lower length-for-age z-scores (LAZ) than GBS-unexposed infants, especially at 2 months. Altered gut microbiota and metabolites in GBS-exposed infants correlated with growth, mediating the impact of maternal GBS on infant LAZ. Changes in the vaginal microbiota of the GBS group during the third trimester correlated with infant LAZ. Additionally, differences in neonatal gut microbiota, metabolites, and vaginal microbiota during pregnancy were identified between infants with overall LAZ&lt;-1 within 8 months after birth and their counterparts, enhancing the discriminatory power of fundamental data for predicting the occurrence of LAZ&lt;-1 during the first 8 months of life. GBS exposure is associated with decreased infant length growth, with altered microbiota and metabolites potentially mediating the effects of maternal GBS on offspring length growth, offering potential targets for predicting and addressing growth impairment.
DOI: 10.6084/m9.figshare.30195733
title: Preoperative anxiety state is an independent risk factor for delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: a single-center retrospective case-control study

description: Delayed gastric emptying (DGE) is one of the prevalent complications following pylorus-preserving pancreaticoduodenectomy (PPPD). Anxiety is one of the common psychological comorbidities among tumor patients. However, its influence on the development of DGE post-PPPD remains elusive. Thus, this study aimed to explore the relationship between anxiety states and the incidence of DGE after PPPD. This single-center, retrospective case-control study enrolled 150 patients who underwent PPPD between January 2020 and December 2022. Preoperative anxiety state was assessed using the Hamilton Anxiety Scale (HAMA), and patients were stratified into two groups based on the presence or absence of DGE. Lastly, risk factors for DGE were analyzed based on clinical data, laboratory indicators, postoperative complications, and other indicators. The incidence of postoperative DGE was 28.67%. Patients who developed DGE had significantly higher body mass index (BMI) (23.50 ± 3.85 vs 22.20 ± 2.39, <i>p</i> = 0.013), a higher prevalence of hypertension (46.51% vs 28.97%, <i>p</i> = 0.040) and anxiety state (72.09% vs 48.60%, <i>p</i> = 0.009), as well as high preoperative blood lipid levels [1.87 (1.30, 2.36) vs 1.39 (0.96, 2.02), <i>p</i> = 0.005] may increase the occurrence of DGE. In contrast, high albumin levels on the third day postoperatively (33.18 ± 4.31 vs 35.23 ± 3.47, <i>p</i> = 0.003) conferred protective effects against DGE. Anxiety state (OR: 2.605, 95%CI: 1.170–6.138, <i>p</i> = 0.019) and high BMI (OR: 1.157, 95%CI: 1.022–1.332, <i>p</i> = 0.021) were identified as independent risk factors for DGE. After propensity score matching, anxiety state (<i>p</i> = 0.042) remained an independent risk factor for DGE. Anxiety state, BMI, hypertension, preoperative blood lipid levels, and albumin level on the third day after surgery were related to the occurrence of DGE after PPPD. Among them, anxiety state was identified as an independent risk factor for DGE. These findings highlight the need for implementing timely and appropriate psychological interventions in patients undergoing PPPD to minimize the risk of postoperative DGE. ClinicalTrials.gov Identifier: ChiCTR2400090370.
DOI: 10.6084/m9.figshare.30195733.v1
title: Preoperative anxiety state is an independent risk factor for delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: a single-center retrospective case-control study

description: Delayed gastric emptying (DGE) is one of the prevalent complications following pylorus-preserving pancreaticoduodenectomy (PPPD). Anxiety is one of the common psychological comorbidities among tumor patients. However, its influence on the development of DGE post-PPPD remains elusive. Thus, this study aimed to explore the relationship between anxiety states and the incidence of DGE after PPPD. This single-center, retrospective case-control study enrolled 150 patients who underwent PPPD between January 2020 and December 2022. Preoperative anxiety state was assessed using the Hamilton Anxiety Scale (HAMA), and patients were stratified into two groups based on the presence or absence of DGE. Lastly, risk factors for DGE were analyzed based on clinical data, laboratory indicators, postoperative complications, and other indicators. The incidence of postoperative DGE was 28.67%. Patients who developed DGE had significantly higher body mass index (BMI) (23.50 ± 3.85 vs 22.20 ± 2.39, <i>p</i> = 0.013), a higher prevalence of hypertension (46.51% vs 28.97%, <i>p</i> = 0.040) and anxiety state (72.09% vs 48.60%, <i>p</i> = 0.009), as well as high preoperative blood lipid levels [1.87 (1.30, 2.36) vs 1.39 (0.96, 2.02), <i>p</i> = 0.005] may increase the occurrence of DGE. In contrast, high albumin levels on the third day postoperatively (33.18 ± 4.31 vs 35.23 ± 3.47, <i>p</i> = 0.003) conferred protective effects against DGE. Anxiety state (OR: 2.605, 95%CI: 1.170–6.138, <i>p</i> = 0.019) and high BMI (OR: 1.157, 95%CI: 1.022–1.332, <i>p</i> = 0.021) were identified as independent risk factors for DGE. After propensity score matching, anxiety state (<i>p</i> = 0.042) remained an independent risk factor for DGE. Anxiety state, BMI, hypertension, preoperative blood lipid levels, and albumin level on the third day after surgery were related to the occurrence of DGE after PPPD. Among them, anxiety state was identified as an independent risk factor for DGE. These findings highlight the need for implementing timely and appropriate psychological interventions in patients undergoing PPPD to minimize the risk of postoperative DGE. ClinicalTrials.gov Identifier: ChiCTR2400090370.
DOI: 10.6084/m9.figshare.28001782
title: Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8<sup>+</sup> T cells by granzyme B and perforin

description: Rectal adenocarcinoma (READ) involves the dysregulated expression of alpha 2,8-Sialyltransferase1 (ST8Sia1) although its role during READ’s progression is unclear. The mRNA level of ST8Sia1 was analyzed based on The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Tumor Immune Estimation Resource (TIMER) 2.0. Furthermore, the prognostic and significance of ST8Sia1 in READ was assessed through Kaplan-Meier curve, univariate, multivariate Cox regression, and receiver operating characteristic (ROC) methods. The role of ST8Sia1 in the READ immune microenvironment was explored using ESTIMATE analysis and TIMER databases. Furthermore, the expression of ST8Sia1 in tissues was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR), western blotting (WB), and immunohistochemistry (IHC). Perforin and Granzyme B secretion by CD8<sup>+</sup> T cells, as well as tumor cell apoptosis, were detected after co-culturing CD8<sup>+</sup> T cells with READ tumor cells and ST8Sia1-overexpression (ST8Sia1-OE) tumor cells. Furthermore, we examined the interaction between ST8Sia1 and TGF-β1 in READ cells. ST8Sia1 exhibited excellent diagnostic capability for READ, with positive correlations to immune response and negative correlations to tumor purity. Increased levels of perforin and Granzyme B from CD8<sup>+</sup> T cells were observed in vitro, enhancing tumor cell apoptosis. ST8Sia1 interacts with TGF-β1, mediating its inhibitory effects on READ development. ST8Sia1 is a potential diagnostic biomarker and therapeutic target for READ, enhancing CD8<sup>+</sup> T cell function and possibly improving patient outcomes through cellular immunotherapy.