cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/9nnzcvc89r
title: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

description: The PI3K pathway is mutated in a substantial set of tumors which includes alterations in PIK3CA and PTEN genes. However PI3K mutations often co-occur with other primary drivers like RAS, RAF, HER2. Also PI3K pathway inhibitors have not been successful in PI3K mutant tumors, attributed primarily to toxicity related issues and adaptive resistance contributed by relief of negative feedback mechanisms (induction of RTKs). Now we show that PTEN, the major negative regulator of PI3K signaling is regulated by the pathway by mTOR-4EBP1 dependent translation thereby constituting a feedback loop. We show that inhibition of PI3K signaling pharmacologically (eg PI3K inhibitors) or physiologically (amino acid or serum starvation) reduces PTEN and contributes to the resuscitation of the pathway and reduces the efficacy of the PI3K inhibitors. Physiological (ligands) or oncogenic stimulation of the pathway induces PTEN levels thereby regulating the duration and amplitude of signaling. Oncogenic induction of the pathway by PIK3CA activating mutations or HER2 overexpression induces the pathway to different degrees and mirrored by the levels in PTEN protein. Therefore PTEN levels maybe an indicator of PI3K pathway output and also serve to limit the output of PIK3CA mutants. We find that co-alterations in PIK3CA and PTEN increases PI3K and mTORC1 signaling greatly as compared to PIK3CA mutation alone, thereby creating a rationale for selection for co-mutations. Consistent with this hypothesis we find that a subset of tumors co-select for these mutations, especially endometrial cancers in which they co-occur in 70% of tumors. The mechanism of this phenomenon was found to be PI3K control of mTOR and its regulation of the cap-dependent translation inhibitor 4E-BP1. This mechanism was further confirmed by removing the 5'UTR of PTEN, conditions in which, PTEN protein was insensitive to PI3K dependent regulation and resulted in increased duration of pathway inhibition and increased efficacy of PI3K inhibitors. We have also built a computational model of the PI3K network consisting of the FOXO-RTK and 4E-BP1-PTEN feedback loops to quantitatively confirm the role of the 4E-BP1-PTEN feedback in determining the steady state and kinetic responses of PTEN and pAKT to PI3K inhibition in multiple cell lines. Overall, our investigation has identified a major homeostatic regulation of the PI3K network that involves regulation of the second most mutated tumor suppressor genes, PTEN, by one of the most mutated oncogenes PI3K. This has major implications for cancer therapy, understanding the biology of PI3K pathway driven tumors and mechanisms that drive homeostasis in the growth factor network.
DOI: 10.17632/5svb3gjzfp
title: Replacing Tobacco with Alternatives Crops: Perspectives from Smallholder Farmers in Uganda

description: Tobacco farming is associated with a number of negative environmental (deforestation; water pollution; soil degradation; biodiversity losses), social effects (increasing poverty; bonded labour and child labour; food security and malnutrition) and occupational health and safety risks (green tobacco sickness; pesticide intoxication; respiratory disorders; dermatological disorders; cancer). The study therefore sought to find sustainable alternative livelihoods for tobacco farmers in Hoima district. The interest was to learn about the beliefs, attitudes and behaviors of tobacco farmers to alternative crops, If willing to shift, why tobacco farmers ought to shift to alternatives, and what potential alternatives would be suitable. This knowledge would be of great importance to better understand what policy should consider in ensuring and protecting tobacco farmers’ livelihoods for community development.
DOI: 10.15468/dl.bbp54m
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Portugal",
 "TaxonKey is Hypericum pubescens Boiss.",
 "Year 1975-2025"
 ]
}

 The dataset includes 6 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001484-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/337d2x33sd
title: Myotenectomy and TRIM28 RNAseq Data

description: Deep RNA sequencing analysis of skeletal muscle to identify transcripts whose expression is regulated by TRIM28 and myotenectomy
DOI: 10.17632/9dvc2nkndh
title: Proof of Twin Primes and Goldbach's Conjecture.

description: Twin prime conjecture, also known as Polignac's conjecture, in number theory, assertion that there are infinitely many twin primes, or pairs of primes that differ by 2 but and more up
DOI: 10.17632/bcv455nw7s
title: Data for: Model of Multiple Identity Tracking (MOMIT) 2.0: Resolving the Serial vs. Parallel Controversy in Tracking

description: Datafiles of Model of Multiple Identity Tracking (MOMIT) 2.0.
DOI: 10.17632/5sck77c9b9
title: Circulating concentrations of progestins used in contraception

description: This dataset is a compilation of published progestin levels in blood plasma or serum, representing the circulating concentrations of progestins commonly used in contraception. The dataset consists of tables supplementary to the manuscript "Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception", submitted to the journal Pharmacology & Therapeutics. In part of this manuscript we discuss possible reasons for the wide inter-individual and inter-study variability in reported serum progestin concentrations. The data was sourced through extensive PubMed searches for serum or plasma concentrations of progestins used in various methods of administration e.g. intramuscular injection, subdermal implant or combined oral contraceptive.
The columns in these tables include progestin concentrations (in nanomolar[nM]/picomolar [pM] or nanograms/milliliter [ng/ml] or picograms/milliliter [pg/ml]) for several different progestins, the concentrations of endogenous estrogen or progesterone or exogenous ethinyl estradiol, the model system used (number of women, any other drugs used in combination, other demographics), the method of quantification used (typically radioimmunoassay [RIA] or liquid chromatography with mass spectrometry [LC-MS]) and the citation for the original reference (listed at the end of each table). Abbreviations are explained at the end of each table. Molecular weights used for concentration conversions between nM-ng/ml or pM-pg/ml are indicated at the end of each table. While organic solvent extraction is always used for LC-MS methods, it is sometimes used prior to RIA: where this information was available, the organic solvent used is reported. Some data may be omitted due to restricted access to the original publication. This is a non-exhaustive, manually compiled list from publications since the 1960s and as such, some mistakes and/or omissions may have unintentionally occurred.
DOI: 10.17632/7p8w52928v
title: A mitochondrial iron-responsive pathway regulated by DELE1. Sekine Y, Houston R et al

description: Raw images of the paper entitled with "A mitochondrial iron-responsive pathway regulated by DELE1." Sekine Y, Houston R et al.
DOI: 10.17632/mz53d2486n
title: Flow cytometry Data

description: This data was generated by flow cytometry for sVCapture to understand where CNVs form in the cell cycle following replication stress. Under low-dose aphidicolin treatment and other drug inhibitors, cells were either synchronized with RO-3306 and then released or remained asynchronized. Samples were treated with propidium iodide and phospho-histone H3 antibody conjugated to Alexa Fluor 488 to collect different fractions of the cell cycle. 

To examine apoptotic state, cells were also treated with cleaved caspase-3 antibody conjugated to Alexa Fluor 647. An etoposide treatment was included as a positive control for apoptosis.
DOI: 10.17632/8bv5nwp383
title: The Persian Gulf's Holocene data: XRF, organic geochemistry, palynology and sediment

description: The dataset contains the results of different analyses on three short sediment cores from deepest areas of the Persian Gulf. It includes organic geochemistry, palynology, sedimentology, C and N analysis and XRF data that are organized in different tabs.
DOI: 10.17632/smt379mfwz
title: The ambient noise cross-correlation functions of the cemtral-southern Tanlu Fault zone

description: The data ZZ_CCfunctions.zip is the Z-Z component of the station-pairs cross-correlation functions computed from the continuous seismic data for the central-southern Tanlu Fault zone. It includes 29 temporary broadband stations available at the Data Management Centre of the China National Seismic Network at the Institute of Geophysics (SEISDMC, DOI:10.11998/SeisDmc/SN, http://www.seisdmc.ac.cn), and 69 permanent broadband stations provided by the China Earthquake Network Center Data Management Center. The time-series length of each station is more than 2 years from 2015-2017.
DOI: 10.17632/xzrszvyhhg
title: Data for: Development of a hybrid system based on convolutional neural networks and support vector machines for recognition and tracking color changes in food during thermal processing

description: A dataset consisting of 374 images of the bread crust, obtained as described by Cotrim and collaborators (Cotrim et al., 2020), distributed in seven baking stages.
DOI: 10.17632/nw9n7fjsp3
title: Boolean Logic Operators - Plasmids

description: Plasmid used in the paper "Genetically encoded Boolean logic operators to sense and integrate phenylpropanoid metabolite levels in plants"
DOI: 10.17632/g6xz3j6hp8
title: Proteomics of venoms of Naja naja and Daboia russelii snakes

description: The current research advises the usages of variations in proteomics of venoms of Naja naja and Daboia russelii for identification of suspected snake venom samples seized by law enforcement agencies across the world, especially in India. Illegal trade of endangered species of snakes and their venoms is prohibited by Indian Wildlife Protection Act, 1972. There are provisions of fines and imprisonments if a person is found involved in such illegal activities. The Naja naja and Daboia russelii, both are endangered species and illegal trading of venoms of both these snakes is frequently encountered by various law enforcement agencies. But to frame charges under Wildlife Protection Law, the enforcement agencies are required to prove beyond any doubt that the seized material is venom illegally milked from these species. The unique proteomes of venoms can be helpful in confirm identification of snake species from which the venom is likely milked.
The data is generated by LC-MS/MS (nano-Liquid Chromatography coupled with Q-Orbitrap mass spectrometr and ProteomeDiscoverer 2.2 software) of crude venoms of Naja naja and Daboia russelii.
DOI: 10.17632/vk8xzr72jy
title: Improvement in global forecast for chaotic time series

description: Abstract In the Polynomial Global Approach to Time Series Analysis, the most costly (computationally speaking) step is the finding of the fitting polynomial. Here we present two routines that improve the forecasting. In the first, an algorithm that greatly improves this situation is introduced and implemented. The heart of this procedure is implemented on the specific routine which performs a mapping with great efficiency. In comparison with the similar procedure of the TimeS package developed by Carl... Title of program: LinMapTS Catalogue Id: AFAJ_v1_0 Nature of problem Time series analysis and improving forecast capability. Versions of this program held in the CPC repository in Mendeley Data AFAJ_v1_0; LinMapTS; 10.1016/j.cpc.2016.05.011 This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018)
DOI: 10.17632/ntx8swxs38
title: Data for: Holocene variations in North Atlantic export productivity as reflected in bathyal benthic foraminifera

description: Smart et al. Benthic foraminifera (&gt;63 µm) counts - ODP-162-980B (Holocene)
DOI: 10.15468/dl.ypjb54
title: Occurrence Download

description: A dataset containing 1014 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is one of (Thailand, Indonesia, Malaysia, Singapore, Philippines, Viet Nam, Timor-Leste, Brunei Darussalam, Cambodia, India)",
 "OccurrenceStatus is Present",
 "TaxonKey is Malayopython reticulatus (Schneider, 1801)"
 ]
}

 The dataset includes 1014 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001485-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/z9y7zf2sf2
title: Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase

description: Raw read counts and source dataset associated with the manuscript on "Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase". All the source codes are available here: https://github.com/zisanurrahman/CRISPRi_EGML_Main
DOI: 10.17632/n6rv4646xp
title: Dual X-ray Absorptiometry of Btg2 knockout mice during starvation

description: Btg2 wild type (Btg2-WT) and Btg2 knockout (Btg2-KO) mice of male and of female were fasted for 48 hours and then re-fed for 24 hours. On each time point, body weight of each mouse, lean body mass and fat mass were measured by dual-energy X-ray absorptiometry (DEXA).  We found Btg2-KO mice consume less fat mass during starvation in both sexes, and have lower bone mineral density in female.
DOI: 10.17632/m5b542v2y8
title: MOx-Sensors Measurements of Formic Acid Treatment against Varroa Mites on Honey Bees

description: Many beekeepers all over the world use formic acid to treat their honey bee colonies against the parasitic mite Varroa destructor. Acid amount, acid concentration and weather conditions are important factors for the success of a treatment. We tested MOx-Sensors to monitor the gas concentration in the hive over time and to enable the implementation of a control loop. The data shows that standard MOx-Sensors, e.g. SGP40, are capable of measuring the change in concentration relevant for the treatment. This data set is accompanying data of the publication "Evaluating and Optimising Formic Acid Treatment against Varroa Mites on Honey Bees with MOx-Sensors and a Control Loop" in Smart Agricultural Technology: https://doi.org/10.1016/j.atech.2023.100342 The data structure is explained in the uploaded readme/ documentation files.
DOI: 10.17632/hy84kd5hwj
title: Original images for Basu et al., PNAS 2020

description: Raw uncropped original images that were used for making figures in Basu et al., PNAS 2020
DOI: 10.17632/4nwtm4k25c
title: Downscaled IMERG precipitation for Kocinka River catchment, Poland

description: Downscaled at 1km of the IMERG daily precipitation for Kocinka River catchment, Poland in netcdf format for the period 01/2015 to 11/2022
DOI: 10.17632/yj6b3m6mvv
title: Data for: A geochemical approach to reconstruct modern dust fluxes and sources to the South Pacific

description: The data file contains REE, Sr, Nd and Pb isotopic date that were used to identify dust sources to the Pacific sector of the Southern Ocean.
DOI: 10.17632/bg9zfr7zhn
title: Trust-game interactions and beliefs in continuous and "All-or-Nothing" investment action spaces.

description: In Gómez-Miñambres, Schniter, & Shields (2020) we conduct two between-subjects experiments to focus our research on “All-or-Nothing” options featured in many trust-based economic interactions. A fundamental issue with restricted investment action spaces is that their imposition may unintentionally affect reciprocity. Drawing from a student sample, we presented participants with an anonymous trust game. In these trust games we manipulate the investor’s action space. In the All-or-Nothing version investors can invest either “all” their endowment or “nothing”. In the other version, they can invest any amount of the endowment. In both versions, the experimenter multiplies the invested amount by three - creating potential gains from trust. Then the trustee receives this and decides how much to reciprocate to the investor. In a second experiment with another student sample we manipulate our description of the “trust game” (i.e. describing either the All-or-Nothing or Continuous version) to investigate effects on beliefs about investor trust and expectations about trustee reciprocity. This data is organized in two files, one for Experiment 1 and one for Experiment 2 described above. Each of these files has (1) a tab with the participants’ economic behavior in the experiment, and (2) a tab with a codebook explaining participants’ data.
DOI: 10.17632/789hrxhtpw
title: Sn-Ag lead free solder alloy heat treatment

description: EBSD data of Sn-Ag (96.5-3.5, % by wt.) before and after heat treatment.
DOI: 10.17632/dwm2ttb5rv
title: Aphid herbivory drives asymmetry in carbon for nutrient exchange between plants and an arbuscular mycorrhizal fungus
DOI: 10.17632/nhbz756wh5
title: Rapid and sustained response of stubborn guttate psoriasis to ustekinumab: A 52-week, two-center, one-arm, observational study

description: Demographic and baseline disease characteristics of Chinese GP patients
DOI: 10.17632/bbwk72nsbb
title: Waste data

description: The data is mainly a primary data which was collected using well-structured questionnaires. The data was collected to examine the public health implications of waste management in Akure, Ondo State, Nigeria. Households in Akure were selected using the multistage sampling procedure. The first stage includes the use of stratified sampling, in which case residential areas in Akure were classified based on population density into three broad groups namely- high density, medium density and low density zones. Subsequently, two (2) prominent residential areas were purposively selected from each zone giving a total of six residential areas in all. The choice of these areas was based on how representative they are of the zone to which they belong (Table 1). The second stage involves the random selection of 30 respondents each from the six residential areas. In all, 180 respondents were sampled, however, only 174 questionnaires were duly filled and hence, used in the analysis.
DOI: 10.17632/bpgz3ghkz7
title: LINF_020009900

description: Protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/dh5pr5j4pd
title: LINF_350048200

description: hypothetical protein - conserved
Leishmania infantum (strain JPCM5)
DOI: 10.17632/dv52g48ypb
title: Data from PestLens biosurveillance articles from 2008-2018, plus genus and country matching lists

description: Data scraped from an online repository 1,925 articles collected by the biosurveillance program, PestLens (2019) from 2008-2018, and then edited. The 1,612 edited records shown had usable information for report date, pest species taxonomy and type, and country of report. 
Also included are the genera and country matching lists.

PestLens (2019) Preclearance and Offshore Programs, Plant Protection and Quarantine, U.S. Department of Agriculture, and Center for Integrated Pest Management, North Carolina State University. https://pestlens.info/. Accessed April 11, 2019
DOI: 10.15468/dl.y67tng
title: Occurrence Download

description: A dataset containing 185 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Pimenta dioica (L.) Merr.)",
 "BasisOfRecord is one of (Machine Observation, Human Observation, Observation, Literature Occurrence)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 185 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001486-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/k5bkhxwtty
title: Behavioural adaptations of the buzzard for foraging along the expressways

description: The expansion of human activities in their many forms is increasing the frequency, diversity and scale of human-wildlife interactions. One such form, a negative one, is the expansion of road infrastructure, causing roadkill and traffic-related noise as well as habitat loss and fragmentation. Even so, habitats around road infrastructure are attractive foraging areas that attract certain bird species. We assessed the impact of road infrastructure on the foraging strategies of the Common Buzzard Buteo buteo. These birds were observed in two habitat types – along an expressway and in an open agricultural landscape – during two winter seasons. In farmland, the buzzards spent most of their time in trees, but on the roads, they spent more time on medium-height hunting sites. Buzzards changed their hunting sites in accordance with the mean wind speed and snow cover; also, they more often changed their sites along the expressway than in farmland. The number of attacks on prey was mediated by the number of hunting site changes and snow cover but not by the habitat types. These results illustrate the high plasticity of the buzzards' behaviour, which can adapt their hunting strategies to both foraging location (expressway vs. farmland) and weather conditions. Roadsides along expressways are indeed attractive foraging areas for this diurnal raptor, so reducing the risk of vehicle collisions with this and other birds of prey may require targeted planning efforts.
DOI: 10.17632/rryh4gbp7g
title: Simultaneously acquired data from contactless and wearable devices for direct and indirect heart-rate measurement

description: Simultaneously acquired data from contactless and wearable devices for direct and indirect heart-rate measurement. For more details see related publication in Data in Brief journal by P.Pierleoni et al.
DOI: 10.15468/dl.rxue3c
title: Occurrence Download

description: A dataset containing 938 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Xysticus emertoni Keyserling, 1880"
 ]
}

 The dataset includes 938 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001515-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/9fjwxm22nt
title: Explicit Listening Strategy Training for Lower-Proficiency EFL Learners

description: This data set is from a quasi-experimental study designed to determine whether or not an explicit listening strategy instruction program can effectively improve lower proficiency EFL learners’ listening skills and self-efficacy as L2 listeners. The sample (N=129) was divided into three groups. The first group (n=43) consisted of two classes and they received 19 hours of strategy training and additional comprehensible listening input (STI). The second group (n=48) received 11 hours of strategy training (ST) only and included three classes. The third group (n=38), receiving no explicit listening strategy instruction, was the control group (CG) and consisted of two classes. Data was gathered at pre- and post-training stages which included (1) a listening comprehension test, (2) a listening cloze test, and (3) TOEIC® listening section scores. Student perceptions of their self-efficacy as L2 listeners were collected with the listening self-efficacy questionnaire (LSEQ) created by Graham and Macaro (2008). Student responses (on a 100-point scale) to the four LSEQ questions are reported in this data set. After our review of the data, we were unable to find any strong empirical evidence that the lower-proficiency EFL learners’ listening performance improved as a result of the explicit listening strategy training.