cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21907814
title: Analysis of the structuring of the Health Care Network in the State of Mato Grosso, Brazil, within the context of Regionalization

description: Abstract The article analyzes aspects of the structuring of the health care network in the regions of the State of Mato Grosso, and the narrative about them, by institutional actors representing management, service providers and society. It is based on research on governance and regionalization of the SUS in this state, with a quantitative and qualitative approach, the empirical basis of which included secondary data, institutional documents and interviews with key actors representing management, service providers and society. In this research, the focus was on coverage of the Family Health Strategy; availability of health services; workforce; expenses on health. Between 2010 and 2018, despite the improvement of several indicators examined: the supply and distribution of services and professionals reveal regional inequalities; there are financial limitations and a lack of services and professionals. The Health Care Network (HCN) is not structured as regulated, but rather as each region - and its municipalities - interprets and adapts it, according to its installed capacity. The PHC network has promoted advances, but it has not been able to be effective and resolute in terms of health needs, not providing care properly nor coordinating the HCN.
DOI: 10.6084/m9.figshare.21907814.v1
title: Analysis of the structuring of the Health Care Network in the State of Mato Grosso, Brazil, within the context of Regionalization

description: Abstract The article analyzes aspects of the structuring of the health care network in the regions of the State of Mato Grosso, and the narrative about them, by institutional actors representing management, service providers and society. It is based on research on governance and regionalization of the SUS in this state, with a quantitative and qualitative approach, the empirical basis of which included secondary data, institutional documents and interviews with key actors representing management, service providers and society. In this research, the focus was on coverage of the Family Health Strategy; availability of health services; workforce; expenses on health. Between 2010 and 2018, despite the improvement of several indicators examined: the supply and distribution of services and professionals reveal regional inequalities; there are financial limitations and a lack of services and professionals. The Health Care Network (HCN) is not structured as regulated, but rather as each region - and its municipalities - interprets and adapts it, according to its installed capacity. The PHC network has promoted advances, but it has not been able to be effective and resolute in terms of health needs, not providing care properly nor coordinating the HCN.
DOI: 10.6084/m9.figshare.21907819
title: Herbal medicines from the industry in the unified health system: challenge faced by medical professionals

description: Abstract The World Health Organization recognized the use of herbal medicines as a therapeutic resource and its application in the primary attention to heath. The begin of this expansion was in 2006, with the National Policy on Integrative and Complementary practices of the Unified Health System (SUS). This research aimed to evaluate the questionnaires applied to doctors, who may have prescribed industrialized herbal medicines and to identify the difficulties involved with the implementation of this therapy as an integrative and complementary practice. It is a quantitative, observational and transversal study conducted in the municipality of Pinhais/Brazil. The questionnaire applied had as themes the experience of personal use of industrialized herbal medicines, improvement after their use. Forty-four individuals from four different nationalities: Brazilian (88.64%), Cuban (6.82%), Mexican (2.27%) and Argentinian (2.27%), ages between 25 and 69 years, mainly male sex (54.55%) answered the questionnaire. According to the study, the doctors consider herbal medicines an alternative to the conventional treatment and these medical professionals have already prescribed some industrialized herbal medications. Despite the difficulties faced by medical doctors with the prescription of herbs, it is possible to define strategies to assist these professionals, such as the incentive the actions by the governments.
DOI: 10.6084/m9.figshare.21907819.v1
title: Herbal medicines from the industry in the unified health system: challenge faced by medical professionals

description: Abstract The World Health Organization recognized the use of herbal medicines as a therapeutic resource and its application in the primary attention to heath. The begin of this expansion was in 2006, with the National Policy on Integrative and Complementary practices of the Unified Health System (SUS). This research aimed to evaluate the questionnaires applied to doctors, who may have prescribed industrialized herbal medicines and to identify the difficulties involved with the implementation of this therapy as an integrative and complementary practice. It is a quantitative, observational and transversal study conducted in the municipality of Pinhais/Brazil. The questionnaire applied had as themes the experience of personal use of industrialized herbal medicines, improvement after their use. Forty-four individuals from four different nationalities: Brazilian (88.64%), Cuban (6.82%), Mexican (2.27%) and Argentinian (2.27%), ages between 25 and 69 years, mainly male sex (54.55%) answered the questionnaire. According to the study, the doctors consider herbal medicines an alternative to the conventional treatment and these medical professionals have already prescribed some industrialized herbal medications. Despite the difficulties faced by medical doctors with the prescription of herbs, it is possible to define strategies to assist these professionals, such as the incentive the actions by the governments.
DOI: 10.6084/m9.figshare.21907817
title: Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats

description: Abstract The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (200 and 400 mg/kg doses, gavage, once daily). Treatments were conducted for 10 days. On the 11th day, blood samples were collected to measure lead acetate levels and biochemical factors. Liver tissue samples were examined for histopathological changes. Lead serum levels were increased in lead acetate-treated rats (p&lt;0.001). Lead acetate treatment was associated with a significant increase in liver tissue damage (p&lt;0.001), while R. ribes extract prevented liver tissue damage (p&lt;0.05). The levels of alanine aminotransferase and aspartate aminotransferase were significantly lower in the groups lead acetate + extract (two doses) than in the lead acetate group (p&lt;0.001 and P&lt;0.01, respectively), but alkaline phosphatase level, prothrombin time, partial thromboplastin time and international normalized ratio were not different between the lead acetate + extract groups and the lead acetate group. The results showed the inhibitory role of R. ribes on lead-induced hepato-toxicity. The results make Rhubarb a good candidate to protect against the deleterious effect of chronic lead intoxication after complementary studies.
DOI: 10.6084/m9.figshare.21907817.v1
title: Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats

description: Abstract The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (200 and 400 mg/kg doses, gavage, once daily). Treatments were conducted for 10 days. On the 11th day, blood samples were collected to measure lead acetate levels and biochemical factors. Liver tissue samples were examined for histopathological changes. Lead serum levels were increased in lead acetate-treated rats (p&lt;0.001). Lead acetate treatment was associated with a significant increase in liver tissue damage (p&lt;0.001), while R. ribes extract prevented liver tissue damage (p&lt;0.05). The levels of alanine aminotransferase and aspartate aminotransferase were significantly lower in the groups lead acetate + extract (two doses) than in the lead acetate group (p&lt;0.001 and P&lt;0.01, respectively), but alkaline phosphatase level, prothrombin time, partial thromboplastin time and international normalized ratio were not different between the lead acetate + extract groups and the lead acetate group. The results showed the inhibitory role of R. ribes on lead-induced hepato-toxicity. The results make Rhubarb a good candidate to protect against the deleterious effect of chronic lead intoxication after complementary studies.
DOI: 10.6084/m9.figshare.21907822
title: Water, sanitation and schistosomiasis mansoni: a study based on the Brazilian National Prevalence Survey (2011-2015)

description: Abstract This study aimed to explore the association between water, sanitation, and the prevalence of schistosomiasis mansoni in students aged 7 to 17 years from all 27 federative units in Brazil. It was a cross-sectional study conducted based on data on the prevalence of schistosomiasis mansoni referring to 197,567 students from 521 Brazilian municipalities, who participated in the National Survey on the Prevalence of Schistosomiasis Mansoni and Soil-transmitted Helminth Infections (2011-2015). Univariable and multivariable generalized linear models of the negative binomial type were adjusted using 25 and 5% significance levels, respectively, considering municipalities as the unit of analysis. While a protective association was found between access to filtered water in schools and schistosomiasis mansoni prevalence, sanitation in schools was indicated as a risk factor. The collection of wastewater through a network is not universal in Brazil, and even when present, it is not necessarily carried out by the treatment of collected effluents, thus often resulting in the direct discharge of raw sewage into water resources. Regarding septic tanks, only the presence of infrastructure alone does not guarantee its correct use by the population.
DOI: 10.6084/m9.figshare.21907822.v1
title: Water, sanitation and schistosomiasis mansoni: a study based on the Brazilian National Prevalence Survey (2011-2015)

description: Abstract This study aimed to explore the association between water, sanitation, and the prevalence of schistosomiasis mansoni in students aged 7 to 17 years from all 27 federative units in Brazil. It was a cross-sectional study conducted based on data on the prevalence of schistosomiasis mansoni referring to 197,567 students from 521 Brazilian municipalities, who participated in the National Survey on the Prevalence of Schistosomiasis Mansoni and Soil-transmitted Helminth Infections (2011-2015). Univariable and multivariable generalized linear models of the negative binomial type were adjusted using 25 and 5% significance levels, respectively, considering municipalities as the unit of analysis. While a protective association was found between access to filtered water in schools and schistosomiasis mansoni prevalence, sanitation in schools was indicated as a risk factor. The collection of wastewater through a network is not universal in Brazil, and even when present, it is not necessarily carried out by the treatment of collected effluents, thus often resulting in the direct discharge of raw sewage into water resources. Regarding septic tanks, only the presence of infrastructure alone does not guarantee its correct use by the population.
DOI: 10.6084/m9.figshare.21907823
title: Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

description: Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effective and safe drug, but genetic and non-genetic factors have been implicated in the interindividual variability of drug response. Several studies have shown the impact of variants of pharmacokinetics or pharmacodynamics-related genes on MPA response in kidney transplantation. This review explored further the influence of genes involved in the immune response on clinical outcomes of kidney recipients on short- or long-term MPA treatment. Variants in genes related to T cell activation (CD28, CTL4, ICOS, PDPC1), pro-inflammatory cytokines (IL2, IL6, IL12A, IL12B, TNF, IFNG), immunomodulatory cytokines (IL4, IL10, TGFB1), and innate immune response (CD14, TLR2, TLR4) were shown to be associated with increased risk of acute rejection, graft function or survival, chronic graft nephropathy, viral infections or MPA-induced myelotoxicity. Some of the significant pharmacogenetic associations were confirmed by meta-analyses of kidney transplantation. These findings are suggestive that variants in immune response-related genes contribute to the variability of MPA response, and have potential application as biomarkers of acute rejection in kidney transplantation.
DOI: 10.6084/m9.figshare.21907823.v1
title: Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

description: Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effective and safe drug, but genetic and non-genetic factors have been implicated in the interindividual variability of drug response. Several studies have shown the impact of variants of pharmacokinetics or pharmacodynamics-related genes on MPA response in kidney transplantation. This review explored further the influence of genes involved in the immune response on clinical outcomes of kidney recipients on short- or long-term MPA treatment. Variants in genes related to T cell activation (CD28, CTL4, ICOS, PDPC1), pro-inflammatory cytokines (IL2, IL6, IL12A, IL12B, TNF, IFNG), immunomodulatory cytokines (IL4, IL10, TGFB1), and innate immune response (CD14, TLR2, TLR4) were shown to be associated with increased risk of acute rejection, graft function or survival, chronic graft nephropathy, viral infections or MPA-induced myelotoxicity. Some of the significant pharmacogenetic associations were confirmed by meta-analyses of kidney transplantation. These findings are suggestive that variants in immune response-related genes contribute to the variability of MPA response, and have potential application as biomarkers of acute rejection in kidney transplantation.
DOI: 10.6084/m9.figshare.21907826
title: Evaluation of farmer’s perception of precision agriculture: A case study in the municipality of Guaíba, Rio Grande do Sul state

description: ABSTRACT Purpose: The main objective of the work was to investigate the perception of rural producers in the municipality of Guaíba, Rio Grande do Sul state, in relation to the implementation of precision agriculture (PA), in order to verify the difficulties and benefits of the implementation of this practice in rural life. Originality/value: PA technology is increasingly present in the planting process, enabling productivity improvement, lower environmental impact, and rural development, an area of fundamental economic importance for the country. Understanding the perception of the farmers in relation to PA can generate important insights, allowing for successful implementations of that technology. Design/methodology/approach: The research was carried out based on semi-structured interviews. Thus, information was obtained on the perceptions of each farmer in the face of digital transformation in the field and the obstacles encountered in the practices of such technology. Data collection was carried out with five farmers in the municipality of Guaíba. Subsequently, the data were analyzed using the content analysis technique, in its variant of propositional discourse analysis. Findings: The results show that, despite all the technological apparatus, there are challenges to be overcome in the face of the implementation of digital agriculture. Among the difficulties mentioned, the complexity of the systems – a fact not yet reported in theory –, lack of qualified personnel, cost of machinery, dependence on the climate, and difficulties in accessing the internet stand out. Benefits of the implementation of PA were also pointed out, such as the lower use of inputs, the better harvest yield, the improvement in the farmer’s technical knowledge, and the possibility of adapting the existing machinery, which, contradictorily, was also pointed out as being a difficulty.
DOI: 10.6084/m9.figshare.21907826.v1
title: Evaluation of farmer’s perception of precision agriculture: A case study in the municipality of Guaíba, Rio Grande do Sul state

description: ABSTRACT Purpose: The main objective of the work was to investigate the perception of rural producers in the municipality of Guaíba, Rio Grande do Sul state, in relation to the implementation of precision agriculture (PA), in order to verify the difficulties and benefits of the implementation of this practice in rural life. Originality/value: PA technology is increasingly present in the planting process, enabling productivity improvement, lower environmental impact, and rural development, an area of fundamental economic importance for the country. Understanding the perception of the farmers in relation to PA can generate important insights, allowing for successful implementations of that technology. Design/methodology/approach: The research was carried out based on semi-structured interviews. Thus, information was obtained on the perceptions of each farmer in the face of digital transformation in the field and the obstacles encountered in the practices of such technology. Data collection was carried out with five farmers in the municipality of Guaíba. Subsequently, the data were analyzed using the content analysis technique, in its variant of propositional discourse analysis. Findings: The results show that, despite all the technological apparatus, there are challenges to be overcome in the face of the implementation of digital agriculture. Among the difficulties mentioned, the complexity of the systems – a fact not yet reported in theory –, lack of qualified personnel, cost of machinery, dependence on the climate, and difficulties in accessing the internet stand out. Benefits of the implementation of PA were also pointed out, such as the lower use of inputs, the better harvest yield, the improvement in the farmer’s technical knowledge, and the possibility of adapting the existing machinery, which, contradictorily, was also pointed out as being a difficulty.
DOI: 10.6084/m9.figshare.21907828
title: The effect of noise on the amplitude and morphology of cortical auditory evoked potentials

description: Abstract Objective: To analyze the effect of noise on electrophysiological measurements (P1-N1-P2 complex) of cortical auditory evoked potentials in normal hearing individuals of different ages. Methods: The inclusion criteria for the study were young individuals, adults and elderly, aged 18–75 years, with auditory thresholds up to 25 dB. Participants were separated according to their age group: G1 (18–25 years old), G2 (31–59 years old) and G3 (60–75 years old). Cortical auditory evoked potentials were elicited with synthetic speech stimulus /da/ presented in two conditions: without masking and with masking (Delta-t 64ms). The results were expressed and analyzed using statistical measures. Results: High latencies and reduced amplitudes were observed in the Delta-t 64 ms condition, in all age groups. There were significant differences between the groups, both in P1 latencies for the two conditions and in N1 latencies in the Delta-t 64 ms condition. P1 latencies in the condition without masking were lower in G1 and P1 and N1 latencies in the Delta-t 64 ms condition were higher in G3. The described results show the influence of noise on cortical responses in all age groups, with G3 being the most affected by the masking presentation. Conclusion: The latency and amplitude measurements vary according to the stimulus presentation condition and age group. The forward masking phenomenon occurred with greater precision in G3. Level of evidence: (2c).
DOI: 10.6084/m9.figshare.21907828.v1
title: The effect of noise on the amplitude and morphology of cortical auditory evoked potentials

description: Abstract Objective: To analyze the effect of noise on electrophysiological measurements (P1-N1-P2 complex) of cortical auditory evoked potentials in normal hearing individuals of different ages. Methods: The inclusion criteria for the study were young individuals, adults and elderly, aged 18–75 years, with auditory thresholds up to 25 dB. Participants were separated according to their age group: G1 (18–25 years old), G2 (31–59 years old) and G3 (60–75 years old). Cortical auditory evoked potentials were elicited with synthetic speech stimulus /da/ presented in two conditions: without masking and with masking (Delta-t 64ms). The results were expressed and analyzed using statistical measures. Results: High latencies and reduced amplitudes were observed in the Delta-t 64 ms condition, in all age groups. There were significant differences between the groups, both in P1 latencies for the two conditions and in N1 latencies in the Delta-t 64 ms condition. P1 latencies in the condition without masking were lower in G1 and P1 and N1 latencies in the Delta-t 64 ms condition were higher in G3. The described results show the influence of noise on cortical responses in all age groups, with G3 being the most affected by the masking presentation. Conclusion: The latency and amplitude measurements vary according to the stimulus presentation condition and age group. The forward masking phenomenon occurred with greater precision in G3. Level of evidence: (2c).