cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30768145.v1
title: The quality of addiction treatment in persistent poverty counties versus non-persistent poverty counties: the role of Medicaid

description: <i>Background:</i> Substance use disorders are more prevalent in areas of extreme poverty. Few studies have evaluated the differences in quality of addiction treatment associated with persistent poverty status (counties where at least 20% of residents have been in poverty for 20 years or more) and Medicaid access. <i>Objective:</i> This study aims to (1) investigate whether there is a difference in the quality of addiction treatment between counties identified as persistent poverty counties and those not and (2) determine the effect of Medicaid expansion on quality. <i>Methods:</i> We analyzed data from the National Substance Use and Mental Health Services Survey and the US Census American Community Survey. We performed fixed and random effects regression analysis to determine the likelihood of access to high-quality care, including evidence-based behavioral health services, medications for addiction, staff accreditation, medical treatment, recovery services, increased access to treatment, personalized-treatment plans, and long-term services. <i>Results:</i> Adjusted regression results revealed that persistent poverty county status was associated with a higher likelihood of access to high-quality care in states that expanded Medicaid (OR = 1.37, 95% CI 1.10, 1.70). Persistent poverty counties were also more likely to provide medical services, rapid access to treatment, and personalized treatment plans. However, only access to medical services remained significant in the unadjusted model in states that did not expand Medicaid (OR = 2.10, 95% CI 1.03, 4.30). <i>Conclusions:</i> Substance treatment providers in persistent poverty counties were more likely to provide higher quality care, but Medicaid expansion played an important role. Implications for substance treatment policy and practitioners are discussed.
DOI: 10.6084/m9.figshare.30053736
title: Associations between COVID impact domains and time to buprenorphine treatment disengagement

description: <i>Background:</i> People with opioid use disorder (OUD) experienced worse outcomes from the COVID-19 pandemic, which disrupted general medical care. <i>Objectives:</i> To quantify COVID-19 impact on OUD treatment disengagement among patients in office-based addiction treatment (OBAT) with buprenorphine. <i>Methods:</i> We recruited 112 outpatients actively on buprenorphine at enrollment from July 2021 to 2022 for telephone surveys within a prospective cohort study. Exposures were six COVID-19 impact domains: personal or family COVID-19 infection, difficulty accessing healthcare/medications, economic stressors, worsening physical or mental health, social isolation, and conflicts and disruptions in the home. The primary outcome was time to OBAT disengagement. We examined associations between each COVID-19 impact domain score and the composite COVID-19 pandemic impact score (a sum of all scores) with time to disengagement using Cox regression models. <i>Results:</i> Average age was 48 years, 56.3% male, 71.2% white/non-Hispanic, 67% Medicaid insurance and 92.9% housed. The majority (74/112) had started in OBAT prior to the pandemic. Median time to disengagement was 271 days. Neither unadjusted nor adjusted analyses showed significant associations between COVID-19 impact domains and time to disengagement. The adjusted hazard ratio for composite COVID-19 impact score was 1.00 (95% CI: 0.99, 1.02). <i>Conclusions:</i> Negative COVID-19 impacts were prevalent among patients in OBAT, but none were significantly associated with time-to-care disengagement. Most patients had multiple protective factors (male, white/non-Hispanic, housed, and Medicaid insurance) and this OBAT rapidly adopted telemedicine, which may have minimized treatment disruption. Preserving patient insurance access and telehealth may maximize OUD treatment retention despite pandemic stressors.
DOI: 10.6084/m9.figshare.30053736.v2
title: Associations between COVID impact domains and time to buprenorphine treatment disengagement

description: <i>Background:</i> People with opioid use disorder (OUD) experienced worse outcomes from the COVID-19 pandemic, which disrupted general medical care. <i>Objectives:</i> To quantify COVID-19 impact on OUD treatment disengagement among patients in office-based addiction treatment (OBAT) with buprenorphine. <i>Methods:</i> We recruited 112 outpatients actively on buprenorphine at enrollment from July 2021 to 2022 for telephone surveys within a prospective cohort study. Exposures were six COVID-19 impact domains: personal or family COVID-19 infection, difficulty accessing healthcare/medications, economic stressors, worsening physical or mental health, social isolation, and conflicts and disruptions in the home. The primary outcome was time to OBAT disengagement. We examined associations between each COVID-19 impact domain score and the composite COVID-19 pandemic impact score (a sum of all scores) with time to disengagement using Cox regression models. <i>Results:</i> Average age was 48 years, 56.3% male, 71.2% white/non-Hispanic, 67% Medicaid insurance and 92.9% housed. The majority (74/112) had started in OBAT prior to the pandemic. Median time to disengagement was 271 days. Neither unadjusted nor adjusted analyses showed significant associations between COVID-19 impact domains and time to disengagement. The adjusted hazard ratio for composite COVID-19 impact score was 1.00 (95% CI: 0.99, 1.02). <i>Conclusions:</i> Negative COVID-19 impacts were prevalent among patients in OBAT, but none were significantly associated with time-to-care disengagement. Most patients had multiple protective factors (male, white/non-Hispanic, housed, and Medicaid insurance) and this OBAT rapidly adopted telemedicine, which may have minimized treatment disruption. Preserving patient insurance access and telehealth may maximize OUD treatment retention despite pandemic stressors.
DOI: 10.25574/11502
title: Chandra X-ray Observatory ObsId 11502

description: The nature of active nuclei in radio galaxies: observations of the 2Jy sample
DOI: 10.6084/m9.figshare.30898356
title: Sex and gender differences in co-occurring substance use and depressive disorders: a systematic review

description: <i>Background:</i> Major depressive disorder (MDD) and substance use disorders (SUDs) frequently co-occur, influenced by sex (biological) and gender (sociocultural) factors. The extent and consistency of these differences across substance types in populations with co-occurring MDD remains unclear. <i>Objectives:</i> This systematic review synthesizes evidence on sex and gender differences in the prevalence, clinical characteristics, and treatment outcomes of individuals with co-occurring MDD and four SUDs: alcohol use disorder (AUD), cannabis use disorder (CUD), opioid use disorder (OUD) and cocaine use disorders (CoUD). <i>Methods:</i> Following PRISMA guidelines, we searched PsycINFO, MEDLINE, and Embase for peer-reviewed studies from inception to present. Eligible studies examined co-occurring MDD and at least one SUD, and disaggregated outcomes by sex or gender. <i>Results:</i> Forty-seven studies were included (<i>N</i> = 648,414), spanning diverse age groups and geographic regions. Women with SUDs were more likely to experience co-occurring MDD, particularly in AUD and OUD; findings were less consistent for CUD and CoUD. Men with MDD were more likely than women to report co-occurring AUD. Co-occurring MDD-SUD conferred increased suicide risk, particularly among women. Treatment-related findings were mixed: some evidence suggested MDD increased relapse risk in men but buffered relapse in women. Common methodological limitations included inconsistent definitions of sex and gender and reliance on cross-sectional designs. <i>Conclusion:</i> Sex and gender shape the risks and treatment trajectories of co-occurring MDD and SUDs, underscoring the need for personalized screening, suicide prevention, and relapse management strategies. Greater conceptual clarity and inclusion of gender-diverse individuals could inform equitable clinical practices and targeted interventions.
DOI: 10.6084/m9.figshare.30898356.v1
title: Sex and gender differences in co-occurring substance use and depressive disorders: a systematic review

description: <i>Background:</i> Major depressive disorder (MDD) and substance use disorders (SUDs) frequently co-occur, influenced by sex (biological) and gender (sociocultural) factors. The extent and consistency of these differences across substance types in populations with co-occurring MDD remains unclear. <i>Objectives:</i> This systematic review synthesizes evidence on sex and gender differences in the prevalence, clinical characteristics, and treatment outcomes of individuals with co-occurring MDD and four SUDs: alcohol use disorder (AUD), cannabis use disorder (CUD), opioid use disorder (OUD) and cocaine use disorders (CoUD). <i>Methods:</i> Following PRISMA guidelines, we searched PsycINFO, MEDLINE, and Embase for peer-reviewed studies from inception to present. Eligible studies examined co-occurring MDD and at least one SUD, and disaggregated outcomes by sex or gender. <i>Results:</i> Forty-seven studies were included (<i>N</i> = 648,414), spanning diverse age groups and geographic regions. Women with SUDs were more likely to experience co-occurring MDD, particularly in AUD and OUD; findings were less consistent for CUD and CoUD. Men with MDD were more likely than women to report co-occurring AUD. Co-occurring MDD-SUD conferred increased suicide risk, particularly among women. Treatment-related findings were mixed: some evidence suggested MDD increased relapse risk in men but buffered relapse in women. Common methodological limitations included inconsistent definitions of sex and gender and reliance on cross-sectional designs. <i>Conclusion:</i> Sex and gender shape the risks and treatment trajectories of co-occurring MDD and SUDs, underscoring the need for personalized screening, suicide prevention, and relapse management strategies. Greater conceptual clarity and inclusion of gender-diverse individuals could inform equitable clinical practices and targeted interventions.
DOI: 10.6084/m9.figshare.29697092
title: Impact of acute binge-like ethanol exposure during the third-trimester equivalent on subicular interneurons in mice

description: <i>Background:</i> In animal models, third-trimester-equivalent acute alcohol exposure (TTAAE) leads to cell death in the subiculum, a hippocampal region critical for long-term memory. Proximal and distal regions of the dorsal subiculum have projections that contribute to different aspects of cognitive processing. GABAergic interneurons regulate excitatory pyramidal neurons in the subiculum, but the long-term effects of TTAAE on these interneurons remain unclear. <i>Objective:</i> To test the hypothesis that TTAAE triggers apoptotic pathways in dorsal subiculum interneurons, leading to a persistent reduction in their numbers and alterations in their functional properties during adolescence. <i>Methods:</i> Postnatal day (P) 7 vesicular GABA transporter (VGAT)-Venus mice were injected (2 × 2.5 mg/kg; subcutaneously, 2 hr apart). Cleaved caspase-3 expression was quantified 8 hr after the last injection. Adolescent neuronal and interneuronal densities were quantified using an anti-NeuN marker and Venus fluorescence. Whole-cell patch-clamp recordings were performed from interneurons and pyramidal neurons. <i>Results:</i> TTAAE activated apoptotic pathways in dorsal subicular interneurons in both regions (proximal, <i>p</i> = .005, g = −1.1; distal, <i>p</i> = .003, g = −1.1). Adolescent neuronal density was significantly decreased in exposed males’ distal dorsal subiculum (<i>p</i> &lt; .0001, g = −0.8). Ethanol exposure decreased instantaneous frequency evoked by 250–400 pA current injection in fast-spiking GABAergic interneurons only in female mice (250: <i>p</i> = .019, g = −1.08; 300–450: <i>p</i> = .038, g = −1.06 to- 1.18) but did not significantly affect spontaneous inhibitory postsynaptic currents (sIPSCs) evoked by interneuronal GABA release onto pyramidal neurons. <i>Conclusion:</i> TTAAE activates apoptotic pathways in subicular interneurons, leading to long-term, sex-specific changes, reducing male neuron density and altering female interneuron function. These effects may underlie memory deficits demonstrated in mice with TTAAE.
DOI: 10.6084/m9.figshare.29697092.v1
title: Impact of acute binge-like ethanol exposure during the third-trimester equivalent on subicular interneurons in mice

description: <i>Background:</i> In animal models, third-trimester-equivalent acute alcohol exposure (TTAAE) leads to cell death in the subiculum, a hippocampal region critical for long-term memory. Proximal and distal regions of the dorsal subiculum have projections that contribute to different aspects of cognitive processing. GABAergic interneurons regulate excitatory pyramidal neurons in the subiculum, but the long-term effects of TTAAE on these interneurons remain unclear. <i>Objective:</i> To test the hypothesis that TTAAE triggers apoptotic pathways in dorsal subiculum interneurons, leading to a persistent reduction in their numbers and alterations in their functional properties during adolescence. <i>Methods:</i> Postnatal day (P) 7 vesicular GABA transporter (VGAT)-Venus mice were injected (2 × 2.5 mg/kg; subcutaneously, 2 hr apart). Cleaved caspase-3 expression was quantified 8 hr after the last injection. Adolescent neuronal and interneuronal densities were quantified using an anti-NeuN marker and Venus fluorescence. Whole-cell patch-clamp recordings were performed from interneurons and pyramidal neurons. <i>Results:</i> TTAAE activated apoptotic pathways in dorsal subicular interneurons in both regions (proximal, <i>p</i> = .005, g = −1.1; distal, <i>p</i> = .003, g = −1.1). Adolescent neuronal density was significantly decreased in exposed males’ distal dorsal subiculum (<i>p</i> &lt; .0001, g = −0.8). Ethanol exposure decreased instantaneous frequency evoked by 250–400 pA current injection in fast-spiking GABAergic interneurons only in female mice (250: <i>p</i> = .019, g = −1.08; 300–450: <i>p</i> = .038, g = −1.06 to- 1.18) but did not significantly affect spontaneous inhibitory postsynaptic currents (sIPSCs) evoked by interneuronal GABA release onto pyramidal neurons. <i>Conclusion:</i> TTAAE activates apoptotic pathways in subicular interneurons, leading to long-term, sex-specific changes, reducing male neuron density and altering female interneuron function. These effects may underlie memory deficits demonstrated in mice with TTAAE.
DOI: 10.6084/m9.figshare.30727301
title: Ethnic identity and religiosity are related to lower alcohol use and cannabis use in Arab American college students

description: <i>Background:</i> Although religious and cultural factors have been related to substance use in various populations, research is needed regarding associations for Arab Americans. <i>Objectives:</i> We examined how ethnic identity and religiosity relate to the odds and frequency of alcohol and cannabis use in Arab American college students during the COVID-19 pandemic, as well as differences by biological sex and Muslim upbringing <i>Methods:</i>Arab American college students (<i>N</i> = 173; M<sub>age</sub> = 20.1, range 17–23; 60.7% female; 44.5% Christian upbringing, 43.9% Muslim upbringing) were recruited through electronic flyers and a psychology subject pool in California. Participants reported their ethnic identity affirmation (i.e. feeling positively about being Arab American) and search (i.e. learning about Arab culture), religiosity, and past-year alcohol and cannabis use <i>Results:</i> Greater ethnic identity affirmation was related to less frequent alcohol (OR = .68, <i>p</i> = .046) and cannabis use over the past year (OR = .58, <i>p</i> = .030), whereas greater ethnic identity search was related to lower odds of alcohol (OR = 0.66, <i>p</i> = .025) and cannabis use (OR = 0.68, <i>p</i> = .025). Greater ethnic identity search was also related to less frequent alcohol use among individuals from Muslim upbringings (OR = .37, <i>p</i> = .004). Greater religiosity was related to less frequent alcohol (OR = .61, <i>p</i> = .015) and cannabis use (OR = .44, <i>p</i> = .005). It was also related to lower odds of using alcohol and cannabis, with significantly stronger associations among individuals from Muslim upbringings (OR = .39, <i>p</i> = .040; OR = .40, <i>p</i> = .048) <i>Conclusion:</i> Ethnic identity and religiosity buffered substance use risk. Culturally tailored interventions and supporting cultural experiences may reduce Arab American students’ substance use.
DOI: 10.6084/m9.figshare.30727301.v1
title: Ethnic identity and religiosity are related to lower alcohol use and cannabis use in Arab American college students

description: <i>Background:</i> Although religious and cultural factors have been related to substance use in various populations, research is needed regarding associations for Arab Americans. <i>Objectives:</i> We examined how ethnic identity and religiosity relate to the odds and frequency of alcohol and cannabis use in Arab American college students during the COVID-19 pandemic, as well as differences by biological sex and Muslim upbringing <i>Methods:</i>Arab American college students (<i>N</i> = 173; M<sub>age</sub> = 20.1, range 17–23; 60.7% female; 44.5% Christian upbringing, 43.9% Muslim upbringing) were recruited through electronic flyers and a psychology subject pool in California. Participants reported their ethnic identity affirmation (i.e. feeling positively about being Arab American) and search (i.e. learning about Arab culture), religiosity, and past-year alcohol and cannabis use <i>Results:</i> Greater ethnic identity affirmation was related to less frequent alcohol (OR = .68, <i>p</i> = .046) and cannabis use over the past year (OR = .58, <i>p</i> = .030), whereas greater ethnic identity search was related to lower odds of alcohol (OR = 0.66, <i>p</i> = .025) and cannabis use (OR = 0.68, <i>p</i> = .025). Greater ethnic identity search was also related to less frequent alcohol use among individuals from Muslim upbringings (OR = .37, <i>p</i> = .004). Greater religiosity was related to less frequent alcohol (OR = .61, <i>p</i> = .015) and cannabis use (OR = .44, <i>p</i> = .005). It was also related to lower odds of using alcohol and cannabis, with significantly stronger associations among individuals from Muslim upbringings (OR = .39, <i>p</i> = .040; OR = .40, <i>p</i> = .048) <i>Conclusion:</i> Ethnic identity and religiosity buffered substance use risk. Culturally tailored interventions and supporting cultural experiences may reduce Arab American students’ substance use.
DOI: 10.25574/11503
title: Chandra X-ray Observatory ObsId 11503

description: The nature of active nuclei in radio galaxies: observations of the 2Jy sample
DOI: 10.25574/11504
title: Chandra X-ray Observatory ObsId 11504

description: The nature of active nuclei in radio galaxies: observations of the 2Jy sample
DOI: 10.25574/11505
title: Chandra X-ray Observatory ObsId 11505

description: The nature of active nuclei in radio galaxies: observations of the 2Jy sample
DOI: 10.25574/11506
title: Chandra X-ray Observatory ObsId 11506

description: The nature of active nuclei in radio galaxies: observations of the 2Jy sample
DOI: 10.25574/11507
title: Chandra X-ray Observatory ObsId 11507

description: The nature of active nuclei in radio galaxies: observations of the 2Jy sample
DOI: 10.25574/11508
title: Chandra X-ray Observatory ObsId 11508

description: Weak-line Quasars: Always X-ray Weak?
DOI: 10.25574/11509
title: Chandra X-ray Observatory ObsId 11509

description: Weak-line Quasars: Always X-ray Weak?
DOI: 10.25574/11510
title: Chandra X-ray Observatory ObsId 11510

description: Weak-line Quasars: Always X-ray Weak?
DOI: 10.21233/n31d9w
title: Hail Lake pollen dataset

description: Raw data for the Hail Lake pollen dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.25574/11512
title: Chandra X-ray Observatory ObsId 11512

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11513
title: Chandra X-ray Observatory ObsId 11513

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11514
title: Chandra X-ray Observatory ObsId 11514

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11515
title: Chandra X-ray Observatory ObsId 11515

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11516
title: Chandra X-ray Observatory ObsId 11516

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11517
title: Chandra X-ray Observatory ObsId 11517

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11518
title: Chandra X-ray Observatory ObsId 11518

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11519
title: Chandra X-ray Observatory ObsId 11519

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11520
title: Chandra X-ray Observatory ObsId 11520

description: The X-ray - TeV Connection in M87
DOI: 10.25574/11530
title: Chandra X-ray Observatory ObsId 11530

description: The Cavities and Jet-cloud Interaction of PKS B2152-699
DOI: 10.25574/11531
title: Chandra X-ray Observatory ObsId 11531

description: Deeply embedded AGNs in infrared ultraluminous starbursts
DOI: 10.25574/11532
title: Chandra X-ray Observatory ObsId 11532

description: Deeply embedded AGNs in infrared ultraluminous starbursts
DOI: 10.25574/11533
title: Chandra X-ray Observatory ObsId 11533

description: Deeply embedded AGNs in infrared ultraluminous starbursts
DOI: 10.25574/11534
title: Chandra X-ray Observatory ObsId 11534

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11535
title: Chandra X-ray Observatory ObsId 11535

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11536
title: Chandra X-ray Observatory ObsId 11536

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11537
title: Chandra X-ray Observatory ObsId 11537

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11538
title: Chandra X-ray Observatory ObsId 11538

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.15468/dl.ukfqcb
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pimelodus mysteriosus",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 10000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 71 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055317-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25574/11539
title: Chandra X-ray Observatory ObsId 11539

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11540
title: Chandra X-ray Observatory ObsId 11540

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11541
title: Chandra X-ray Observatory ObsId 11541

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11542
title: Chandra X-ray Observatory ObsId 11542

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11543
title: Chandra X-ray Observatory ObsId 11543

description: The Size of Quasar Non-Thermal/X-ray Emission Regions
DOI: 10.25574/11544
title: Chandra X-ray Observatory ObsId 11544

description: The Size of Quasar Non-Thermal/X-ray Emission Regions