cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19901358.v1
title: Pterygoplichthys spp. (Siluriformes: Loricariidae) meal is suitable for the culture of Nile tilapia Oreochromis niloticus (Cichlidae) juveniles

description: ABSTRACT: We search for positive utility impact on the invasive species Pterygoplichthys spp. The optimal level of replacement of sardine meal (SM) by Pterygoplichthys spp. meal (PLM) in practical feeds for fry of Nile tilapia (Oreochromis niloticus) was evaluated. We evaluated six experimental diets: 50% PLM-50% SM, 60% PLM-40% SM, 70% PLM-30% SM, 80% PLM-20% SM, 90% PLM-10% SM and 100% PLM-0% SM. In a recirculation system, 270 sex-reversed tilapia fry were used (0.7 ± 0.1 g). Diets were administered in triplicate and the experiment lasted 56 days with sampling every 14 days. There were no statistical differences in growth. At the end of the experiment, the SGR, ADG, CF, WG, DFI, FCR and PER were determined without significant differences (P &gt; 0.05) between treatments, but there was a tendency that could indicated higher WG and PER in the 90% PLM-10% SM treatment (93.56 ± 0.43% and 8.44 ± 1.18 g, respectively). All survival rates were higher than 90% with no significant differences. Additionally, there were no statistical differences in the chemical composition of the whole fish, while apparent digestibility coefficients of protein (81-90%) and lipids (87-93%) also showed no significant differences. We concluded that 100% PLM can replace 100% SM in feeding fry of O. niloticus without affecting their survival, growth or chemical composition or the apparent digestibility of nutrients.
DOI: 10.6084/m9.figshare.19901370
title: Temporal Trend of Mortality Due to Ischemic Heart Diseases in Northeastern Brazil (1996–2016): An Analysis According to Gender and Age Group

description: Abstract Background Ischemic heart disease (IHD) is the leading cause of death among cardiovascular diseases (CVD). Objective To describe the sociodemographic profile and analyze the trend in the mortality rate due to IHD, according to sex and by age group, in the states of the Northeast region of Brazil, from 1996 to 2016. Methods Ecological study involving IHD mortality in the northeastern states. Variables analyzed: sex, age, education, marital status, ICD-10 category and state of residence. Crude and standardized rates were calculated. Death data were collected from the Mortality Information System (SIM) and population data from the Brazilian Institute of Geography and Statistics (IBGE). In temporal analyzes the regression model by inflection points was used, with the calculation of annual percent change (APC) and average annual percent change of the period (AAPC). A 95% confidence interval and a significance level of 5% were considered. Results 405916 deaths due to IHD were registered in the northeast region during the study period. The death profile is characterized by men (n=229006; 56,42%), elderly (n=301379; 74,25%), race/color brown (n=197936; 48,76%), elementary or &lt;4 years at school (n=232599; 57,30%) and married (n=179599; 44,25%). There was an unusual highlight to the increase in the annual growth rate in the age group of adolescents (AAPC: 5,2%, p &lt;0.01). The standardized regional mortality rate grew from 30,7 per 100,000 inhabitants in 1996 to 53.8 per 100,000 in 2016 (AAPC 2.8%; p&lt;0.01). All nine states presented a statistically significant growth trend, with emphasis on Maranhão (AAPC 7,6%; p&lt;0.01) and Piauí (AAPC 6,0%; p&lt;0.01). Conclusion The prevalent observed profile was male, elderly, race/color brown, low education level and married. Mortality due to IHD presented an upward trend in all states, although with an uneven pattern among the federated units.
DOI: 10.6084/m9.figshare.19901370.v1
title: Temporal Trend of Mortality Due to Ischemic Heart Diseases in Northeastern Brazil (1996–2016): An Analysis According to Gender and Age Group

description: Abstract Background Ischemic heart disease (IHD) is the leading cause of death among cardiovascular diseases (CVD). Objective To describe the sociodemographic profile and analyze the trend in the mortality rate due to IHD, according to sex and by age group, in the states of the Northeast region of Brazil, from 1996 to 2016. Methods Ecological study involving IHD mortality in the northeastern states. Variables analyzed: sex, age, education, marital status, ICD-10 category and state of residence. Crude and standardized rates were calculated. Death data were collected from the Mortality Information System (SIM) and population data from the Brazilian Institute of Geography and Statistics (IBGE). In temporal analyzes the regression model by inflection points was used, with the calculation of annual percent change (APC) and average annual percent change of the period (AAPC). A 95% confidence interval and a significance level of 5% were considered. Results 405916 deaths due to IHD were registered in the northeast region during the study period. The death profile is characterized by men (n=229006; 56,42%), elderly (n=301379; 74,25%), race/color brown (n=197936; 48,76%), elementary or &lt;4 years at school (n=232599; 57,30%) and married (n=179599; 44,25%). There was an unusual highlight to the increase in the annual growth rate in the age group of adolescents (AAPC: 5,2%, p &lt;0.01). The standardized regional mortality rate grew from 30,7 per 100,000 inhabitants in 1996 to 53.8 per 100,000 in 2016 (AAPC 2.8%; p&lt;0.01). All nine states presented a statistically significant growth trend, with emphasis on Maranhão (AAPC 7,6%; p&lt;0.01) and Piauí (AAPC 6,0%; p&lt;0.01). Conclusion The prevalent observed profile was male, elderly, race/color brown, low education level and married. Mortality due to IHD presented an upward trend in all states, although with an uneven pattern among the federated units.
DOI: 10.6084/m9.figshare.19901383
title: Spina bifida, diplomyelia and multiple malformations in a Texel lamb

description: ABSTRACT: This report described the clinical and pathological aspects of open spina bifida and diplomyelia along with multiple congenital malformations in a Texel lamb. Clinically, paresis of the thoracic limbs, paralysis of the pelvic limbs and a cutaneous opening in the lumbosacral region were observed. At necropsy, there was a focally extensive disruption of the skin associated with an absence of the dorsal portions of the lumbosacral vertebrae. Additionally, diplomyelia of the lumbar segment, mild hydromyelia of thoracic segment, and moderate communicating hydrocephalus of the lateral and third ventricles were noted. Possible viral etiologies (bovine viral diarrhea virus, bluetongue virus, and Schmallemberg virus) were not detected by RT-PCR, and toxic plants were not identified. Therefore, a possible genetic cause may not be discarded.
DOI: 10.6084/m9.figshare.19901383.v1
title: Spina bifida, diplomyelia and multiple malformations in a Texel lamb

description: ABSTRACT: This report described the clinical and pathological aspects of open spina bifida and diplomyelia along with multiple congenital malformations in a Texel lamb. Clinically, paresis of the thoracic limbs, paralysis of the pelvic limbs and a cutaneous opening in the lumbosacral region were observed. At necropsy, there was a focally extensive disruption of the skin associated with an absence of the dorsal portions of the lumbosacral vertebrae. Additionally, diplomyelia of the lumbar segment, mild hydromyelia of thoracic segment, and moderate communicating hydrocephalus of the lateral and third ventricles were noted. Possible viral etiologies (bovine viral diarrhea virus, bluetongue virus, and Schmallemberg virus) were not detected by RT-PCR, and toxic plants were not identified. Therefore, a possible genetic cause may not be discarded.
DOI: 10.6084/m9.figshare.19901404
title: Rare deep-water crabs (Crustacea: Decapoda) from Indian waters, with description of one new species

description: Abstract Deep-water brachyuran crabs collected from the Indian Exclusive Economic Zone by the Fishery Oceanographic Research Vessel “Sagar Sampada” in the southeastern Arabian Sea (50 m depth), southwestern Bay of Bengal (307 m depth), and in the vicinity of the Andaman and Nicobar Archipelagos (271-535 m depth) were studied. They are referred to Sphaerodromia kendalli (Alcock and Anderson, 1894) and Sphaerodromia nux Alcock, 1900 (family Dromiidae), Intesius brevipes sp. nov. (family Mathildellidae), Tunepugettia corbariae B.Y. Lee, Richer de Forges and P.K.L. Ng, 2019 (family Epialtidae), Cyrtomaia suhmii Miers, 1885 (family Inachidae), Chaceon alcocki Ghosh and Manning, 1993 (family Geryonidae), and Sphenomerides trapezioides (Wood-Mason, 1891) (family Trapeziidae). Sphaerodromia nux and T. corbariae are new records from Indian waters. The first male specimen of C. alcocki is reported, with a description of the male first gonopod. Intesius brevipes sp. nov. is the fifth species of the genus, differing from the four known congeners in the form and setation of the carapace, distinctly curved and granular anterolateral margins, and shorter pereopods with much slender merus and carpus articles.
DOI: 10.6084/m9.figshare.19901404.v1
title: Rare deep-water crabs (Crustacea: Decapoda) from Indian waters, with description of one new species

description: Abstract Deep-water brachyuran crabs collected from the Indian Exclusive Economic Zone by the Fishery Oceanographic Research Vessel “Sagar Sampada” in the southeastern Arabian Sea (50 m depth), southwestern Bay of Bengal (307 m depth), and in the vicinity of the Andaman and Nicobar Archipelagos (271-535 m depth) were studied. They are referred to Sphaerodromia kendalli (Alcock and Anderson, 1894) and Sphaerodromia nux Alcock, 1900 (family Dromiidae), Intesius brevipes sp. nov. (family Mathildellidae), Tunepugettia corbariae B.Y. Lee, Richer de Forges and P.K.L. Ng, 2019 (family Epialtidae), Cyrtomaia suhmii Miers, 1885 (family Inachidae), Chaceon alcocki Ghosh and Manning, 1993 (family Geryonidae), and Sphenomerides trapezioides (Wood-Mason, 1891) (family Trapeziidae). Sphaerodromia nux and T. corbariae are new records from Indian waters. The first male specimen of C. alcocki is reported, with a description of the male first gonopod. Intesius brevipes sp. nov. is the fifth species of the genus, differing from the four known congeners in the form and setation of the carapace, distinctly curved and granular anterolateral margins, and shorter pereopods with much slender merus and carpus articles.
DOI: 10.6084/m9.figshare.19901427
title: STUDY ON THE OPTIMIZATION FOR THE SIZE OF FUEL CELL FLOW FIELD UNDER INADEQUATE AIR SUPPLY CONDITION

description: In this paper, the influence of the optimization for flow field size on the proton exchange membrane fuel cell (PEMFC) performance under the inadequate air supply of cathode was studied based on the three-dimensional, steady-state, and constant temperature PEMFC monomer model. Additionally, the effect of the optimization for hybrid factors, including length, width, depth and width-depth, on the PEMFC performance was also investigated. The results showed that the optimization of the flow field size can improve the performance of the PEMFC and ensure that it is close to the level under the normal gas supply.
DOI: 10.6084/m9.figshare.19901427.v1
title: STUDY ON THE OPTIMIZATION FOR THE SIZE OF FUEL CELL FLOW FIELD UNDER INADEQUATE AIR SUPPLY CONDITION

description: In this paper, the influence of the optimization for flow field size on the proton exchange membrane fuel cell (PEMFC) performance under the inadequate air supply of cathode was studied based on the three-dimensional, steady-state, and constant temperature PEMFC monomer model. Additionally, the effect of the optimization for hybrid factors, including length, width, depth and width-depth, on the PEMFC performance was also investigated. The results showed that the optimization of the flow field size can improve the performance of the PEMFC and ensure that it is close to the level under the normal gas supply.
DOI: 10.6084/m9.figshare.19901428
title: Multivariate Optimization Applied to the Synthesis of Meglumine Antimoniate with Low Levels of Trivalent Antimony

description: Meglumine antimoniate (MA) is a pentavalent antimony (SbV) drug recommended for the treatment of leishmaniasis. It is known that the trivalent antimony (SbIII) present as a residue in MA contributes to the drug side effects. In this article, multivariate optimization was used in the synthesis of MA in order to obtain a drug with low levels of SbIII. Four variables (source of antimony, temperature, water volume and pH) were preliminarily evaluated by 24-1 fractional factorial design. Central composite design (CCD) was used to determine the optimal synthesis conditions, using two different sources of SbV and the significant variables selected in a fractional factorial design. Response surface methodology obtained by CCD provided a model with non-significant regression (p = 0.05) for the synthetic route via KSb(OH)6. On the other hand, synthetic route via SbCl5 reached minimum value of SbIII content of 0.172% and significant regression, and it was selected for further evaluations. The analysis of MA formulations synthesized with SbCl5 under optimized conditions revealed the efficiency of multivariate optimization to reduce SbIII content. In addition, the monitoring of some physicochemical parameters of these formulations maintained at 40 ºC for 90 days, showed that stability was not altered at 95% confidence level.
DOI: 10.6084/m9.figshare.19901428.v1
title: Multivariate Optimization Applied to the Synthesis of Meglumine Antimoniate with Low Levels of Trivalent Antimony

description: Meglumine antimoniate (MA) is a pentavalent antimony (SbV) drug recommended for the treatment of leishmaniasis. It is known that the trivalent antimony (SbIII) present as a residue in MA contributes to the drug side effects. In this article, multivariate optimization was used in the synthesis of MA in order to obtain a drug with low levels of SbIII. Four variables (source of antimony, temperature, water volume and pH) were preliminarily evaluated by 24-1 fractional factorial design. Central composite design (CCD) was used to determine the optimal synthesis conditions, using two different sources of SbV and the significant variables selected in a fractional factorial design. Response surface methodology obtained by CCD provided a model with non-significant regression (p = 0.05) for the synthetic route via KSb(OH)6. On the other hand, synthetic route via SbCl5 reached minimum value of SbIII content of 0.172% and significant regression, and it was selected for further evaluations. The analysis of MA formulations synthesized with SbCl5 under optimized conditions revealed the efficiency of multivariate optimization to reduce SbIII content. In addition, the monitoring of some physicochemical parameters of these formulations maintained at 40 ºC for 90 days, showed that stability was not altered at 95% confidence level.
DOI: 10.5281/zenodo.6586749
title: Dataset for Latella, I., Ben-Abdallah, P. Graphene-based autonomous pyroelectric system for near-field energy conversion. Sci Rep 11, 19489 (2021)

description: This dataset contains data associated to plots published in the paper I. Latella and P. Ben-Abdallah, Graphene-based autonomous pyroelectric system for near-field energy conversion, Sci Rep 11, 19489 (2021), https://doi.org/10.1038/s41598-021-98656-8.
DOI: 10.5281/zenodo.6586748
title: Dataset for Latella, I., Ben-Abdallah, P. Graphene-based autonomous pyroelectric system for near-field energy conversion. Sci Rep 11, 19489 (2021)

description: This dataset contains data associated to plots published in the paper I. Latella and P. Ben-Abdallah, Graphene-based autonomous pyroelectric system for near-field energy conversion, Sci Rep 11, 19489 (2021), https://doi.org/10.1038/s41598-021-98656-8.
DOI: 10.6084/m9.figshare.19901445
title: OPTIMIZATION AND VALIDATION OF A SIMPLE AND LOW-COST SEMI-QUANTITATIVE ENZYMATIC METHOD TO SEARCH FOR CISTEINE PROTEASES INHIBITORS.

description: Cysteine proteases are an important class of enzymes involved in several essential biological processes. For this reason, these enzymes are important therapeutic targets, and therefore can be used in enzymatic assays for the search of hits. The most widely used methods in the search of enzyme inhibitors are spectrophotometric, however they have relatively high operational costs. For this reason, simpler, and cheaper methods can be useful in the search for enzyme inhibitors. In this work, a simple and low-cost semi-quantitative method was optimized and validated using papain and skimmed powdered milk (casein) as a substrate. The ideal condition for the method was the one that used powdered milk, 0.250%, papain solution, 9.4 mg mL-1 and incubation time, 18 h. The method validation was performed using the inhibitor E64 and herb extracts, in different concentrations. After carrying out the experiments and statistical analyses, a high reproducibility can be observed, with relative standard deviations below 2.1%. Plant extracts were used to test the method and the results indicated that these extracts are promising for the search of cysteine protease inhibitors. The method developed here has simplicity and reproducibility and has great application, as preliminary study, in the search for inhibitors of cysteine proteases.
DOI: 10.6084/m9.figshare.19901445.v1
title: OPTIMIZATION AND VALIDATION OF A SIMPLE AND LOW-COST SEMI-QUANTITATIVE ENZYMATIC METHOD TO SEARCH FOR CISTEINE PROTEASES INHIBITORS.

description: Cysteine proteases are an important class of enzymes involved in several essential biological processes. For this reason, these enzymes are important therapeutic targets, and therefore can be used in enzymatic assays for the search of hits. The most widely used methods in the search of enzyme inhibitors are spectrophotometric, however they have relatively high operational costs. For this reason, simpler, and cheaper methods can be useful in the search for enzyme inhibitors. In this work, a simple and low-cost semi-quantitative method was optimized and validated using papain and skimmed powdered milk (casein) as a substrate. The ideal condition for the method was the one that used powdered milk, 0.250%, papain solution, 9.4 mg mL-1 and incubation time, 18 h. The method validation was performed using the inhibitor E64 and herb extracts, in different concentrations. After carrying out the experiments and statistical analyses, a high reproducibility can be observed, with relative standard deviations below 2.1%. Plant extracts were used to test the method and the results indicated that these extracts are promising for the search of cysteine protease inhibitors. The method developed here has simplicity and reproducibility and has great application, as preliminary study, in the search for inhibitors of cysteine proteases.
DOI: 10.6084/m9.figshare.19901446.v1
title: Integrated UPLC-HRMS, Chemometric Tools, and Metabolomic Analysis of Forage Palm (Opuntia spp. and Nopalea spp.) to Define Biomarkers Associated with Non-Susceptibility to Carmine Cochineal (Dactylopius opuntiae)

description: Metabolomics, together with analytical methods and chemometric tools, point to new paths for selecting species that are resistant to pests and diseases. In this work, the forage palm species' metabolomic profile was investigated, and the relation between the chemical composition and resistance to Dactylopius opuntiae (carmine cochineal). The study was performed in cladodes of different non-susceptible cultivars (Nopalea cochenillifera (L.) Salm-Dyck, Opuntia stricta (Haw.), Nopalea cochenillifera and susceptible cultivar (Opuntia ficus-indica (L.) Mill.)). Metabolic profile showed 28 metabolites detected in the four species. From these total, 18 metabolites were annotated using UPLC-QTOF-MSE (ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode). By comparing the chemical profiles of non-susceptible and susceptible species through the application of chemometric tools, it was possible to obtain biomarkers (quercetin-3-O-2',6'-dirhamnosylglucoside, quercetin rhamnosyl dihexoside, and isorhamnetin-3-sophoroside-7-rhamnoside) that may be associated with resistance to carmine cochineal. Metabolomics based on UPLC-QTOF-MSE and chemometric allowed to establish the biomarkers knowledge of the resistance present in forage palm species. These results contribute to developing the initial understanding of flavonoids' role in the defense mechanisms of cactaceans and can be useful for application in breeding programs; it can increase the chances of success in creating new varieties of plants not susceptible to carmine cochineal.
DOI: 10.6084/m9.figshare.19901446
title: Integrated UPLC-HRMS, Chemometric Tools, and Metabolomic Analysis of Forage Palm (Opuntia spp. and Nopalea spp.) to Define Biomarkers Associated with Non-Susceptibility to Carmine Cochineal (Dactylopius opuntiae)

description: Metabolomics, together with analytical methods and chemometric tools, point to new paths for selecting species that are resistant to pests and diseases. In this work, the forage palm species' metabolomic profile was investigated, and the relation between the chemical composition and resistance to Dactylopius opuntiae (carmine cochineal). The study was performed in cladodes of different non-susceptible cultivars (Nopalea cochenillifera (L.) Salm-Dyck, Opuntia stricta (Haw.), Nopalea cochenillifera and susceptible cultivar (Opuntia ficus-indica (L.) Mill.)). Metabolic profile showed 28 metabolites detected in the four species. From these total, 18 metabolites were annotated using UPLC-QTOF-MSE (ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode). By comparing the chemical profiles of non-susceptible and susceptible species through the application of chemometric tools, it was possible to obtain biomarkers (quercetin-3-O-2',6'-dirhamnosylglucoside, quercetin rhamnosyl dihexoside, and isorhamnetin-3-sophoroside-7-rhamnoside) that may be associated with resistance to carmine cochineal. Metabolomics based on UPLC-QTOF-MSE and chemometric allowed to establish the biomarkers knowledge of the resistance present in forage palm species. These results contribute to developing the initial understanding of flavonoids' role in the defense mechanisms of cactaceans and can be useful for application in breeding programs; it can increase the chances of success in creating new varieties of plants not susceptible to carmine cochineal.
DOI: 10.6084/m9.figshare.19901457
title: Polyphenol Profile and Quantitative Assessment of the Flavonoid Kaempferitrin in Wild and Cultivated Brazilian Amazonian Uncaria guianensis (Rubiaceae)

description: The Amazonian Rubiaceae species Uncaria guianensis (UG) is locally used as anti-inflammatory, antitumor, antidiabetic, anti-ulcers, and others. The phenolic content of its leaves is characterized by the great predominance of the flavonoid kaempferol-3,7-O-(α)-L-dirhamnoside (kaempferitrin). The present study quantitatively evaluates the kaempferitrin content in the leaves and branches of cultivated and wild UG specimens collected in different locations of the Brazilian Amazon rainforest by employing high-performance liquid chromatography coupled to a diode array detector (HPLC-DAD). Besides, the understanding of the polyphenol profile performed by electron spray ionization is deepened by tandem mass spectrometry analysis (ESI-MS/MS), using a previously approached leaf UG extract, and the flavonoid quercetin-3,7-O-(α)-L-dirhamnoside was first isolated from UG. All samples showed quite similar qualitative polyphenol profiles. Kaempferitrin in UG ranged from 1.1 to 1.9 mg 100 mg-1 for dry leaves of adult wild plants, 0.3 to 0.7 mg 100 mg-1 for dry leaves of cultivated young plants and 0.00 to 0.04 mg 100 mg-1 for dry branches of adult wild plants. Besides suggesting the distribution of kaempferitrin in the species, these results reinforce this flavonol as a suitable chemical marker for UG leaves and the products derived from them.