cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28428917
title: Supplementary Material for: Treatment effects of combined transoral injection laryngoplasty with short voice therapy in patients with unilateral vocal fold immobility – a pilot study

description: Introduction: Injection laryngoplasty (IL) in combination with short voice therapy (SVT) has been recommended in unilateral vocal fold immobility (UVFI). This pilot study investigated functional voice changes, age, and time-to-treatment effects in UVFI after transoral IL with hyaluronic acid (HA) and SVT. 
Methods: 17 adults with UVFI (mean age: 61 years) were retrospectively analyzed. Outcome measures were the Voice Handicap Index 9i (VHI-9i), perceptual Grading-Roughness-Breathiness-Asthenia-Strain (GRBAS) Scale, voice range profiles (VRP) of the speaking, calling, and singing voice, maximum phonation time (MPT), jitter, and the Dysphonia Severity Index (DSI). T-tests and Wilcoxon tests evaluated treatment effects; age and time-to-treatment effects on the magnitude of change were assessed by Spearman’s correlation. 
Results: There were significant improvements in VHI-9i and GRBAS scale overall G, R, B, and A. Mean speaking and mean calling sound pressure level (SPL), maximum singing SPL, and mean calling fundamental frequency (f0) increased, while the DSI and jitter improved. Time-to-treatment significantly affected the magnitude of change in mean speaking and maximum singing SPL, singing SPL range, jitter, and DSI; age influenced minimum speaking f0 only. 
Conclusion: Transoral IL with SVT significantly improves subjective, perceptual, and instrumental acoustic voice outcomes in UVFI. Improvement of speaking and calling VRP after IL have not been previously documented. Our findings suggest that early treatment is beneficial for mean speaking loudness, maximum singing SPL, singing SPL range, jitter, and the DSI. More research is needed to examine the influence of time-to-treatment and age, and also to what extent SVT contributes to treatment effects.
DOI: 10.6084/m9.figshare.28428917.v1
title: Supplementary Material for: Treatment effects of combined transoral injection laryngoplasty with short voice therapy in patients with unilateral vocal fold immobility – a pilot study

description: Introduction: Injection laryngoplasty (IL) in combination with short voice therapy (SVT) has been recommended in unilateral vocal fold immobility (UVFI). This pilot study investigated functional voice changes, age, and time-to-treatment effects in UVFI after transoral IL with hyaluronic acid (HA) and SVT. 
Methods: 17 adults with UVFI (mean age: 61 years) were retrospectively analyzed. Outcome measures were the Voice Handicap Index 9i (VHI-9i), perceptual Grading-Roughness-Breathiness-Asthenia-Strain (GRBAS) Scale, voice range profiles (VRP) of the speaking, calling, and singing voice, maximum phonation time (MPT), jitter, and the Dysphonia Severity Index (DSI). T-tests and Wilcoxon tests evaluated treatment effects; age and time-to-treatment effects on the magnitude of change were assessed by Spearman’s correlation. 
Results: There were significant improvements in VHI-9i and GRBAS scale overall G, R, B, and A. Mean speaking and mean calling sound pressure level (SPL), maximum singing SPL, and mean calling fundamental frequency (f0) increased, while the DSI and jitter improved. Time-to-treatment significantly affected the magnitude of change in mean speaking and maximum singing SPL, singing SPL range, jitter, and DSI; age influenced minimum speaking f0 only. 
Conclusion: Transoral IL with SVT significantly improves subjective, perceptual, and instrumental acoustic voice outcomes in UVFI. Improvement of speaking and calling VRP after IL have not been previously documented. Our findings suggest that early treatment is beneficial for mean speaking loudness, maximum singing SPL, singing SPL range, jitter, and the DSI. More research is needed to examine the influence of time-to-treatment and age, and also to what extent SVT contributes to treatment effects.
DOI: 10.6084/m9.figshare.28428920
title: Supplementary Material for: Limb salvage by repetitive radical surgery in recurrently spreading myxofibrosarcoma – Case report and literature review

description: Introduction: We report the case of a 70-year-old athletic female who was advised to undergo leg amputation following an R1 resection at another institution. Due to the patient's insistence on limb preservation, she underwent 17 resections for recurrent tumors in the proximal lower leg and distal thigh, accompanied by reconstruction with two free flaps and adjuvant radiotherapy. Histopathological analysis revealed a widespread, recurrent, cell-poor myxofibrosarcoma with prominent vascular architecture, measuring 6 x 3.5 x 2 cm, and staged as cT2 N0 M0, G2.
Case Presentation: After 17 resections targeting the periphery of previously excised lesions, combined with soft tissue reconstruction and 60 gray (Gy) irradiation, the patient has remained recurrence-free for over 10 years. At 80 years old, she continues to lead an active lifestyle, regularly engaging in sports. This outcome partly contrasts with our systematic literature review, which found a recurrence rate of up to 60% for aggressive surgical strategies in myxofibrosarcoma of the extremities, often requiring multiple surgeries, including amputations. 
Conclusion. Recurrent myxofibrosarcoma should be treated with radical surgical intervention, even in cases of multiple recurrences beyond the original tumor site. By employing free flap reconstruction combined with irradiation, limb preservation can be facilitated, offering patients the potential to maintain functionality and quality of life.
DOI: 10.6084/m9.figshare.28428923
title: Supplementary Material for: RNA-based next-generation sequencing approach to non-small cell lung cancer: A single center experience in Turkey

description: Introduction: Lung cancer is a global health concern. Molecular analysis of tumor tissues, especially in non-small cell lung cancers, has become an integral part of a holistic approach to the management of the disease. Here, molecular genetic data obtained from tumor tissues collected from 373 male and 89 female patients referred to our clinic with a diagnosis of non-small cell lung cancer are presented.
Methods: Patient samples (n=462) were assessed via next-generation sequencing using an RNA-based kit containing 36 genes. Data obtained were analyzed using relevant software, and results of analysis are presented together with the demographic characteristics of the patients.
Results: Significant somatic variations were detected in 208 of 462 patients. KRAS and EGFR had the greatest variations. Rearrangements, mostly involving ALK, were observed in 37 patients, and rare complex changes involving different genes were detected in 10 patients.
Conclusion: This study presents the comprehensive molecular data obtained using an RNA-based kit that provided information on single nucleotide variation (SNV)/insertion-deletion variants (IndDel) and rearrangements in a large patient series from a single center. Somatic variants were detected in approximately 45% of all patients. According to the Catalogue of Somatic Mutations In Cancer (COSMIC) database, our rate of variants detected in KRAS and FGFR3 genes was higher. The rate of variants detected in other genes was lower. In addition, fusions not reported in COSMIC were detected. With the development of next-generation sequencing-based tests and an increase in their use, a broad perspective has been provided to many disease groups, including solid tissue cancers, especially non-small cell lung cancers.
DOI: 10.6084/m9.figshare.28428926
title: Supplementary Material for: Successful treatment of poikilodermatous mycosis fungoides with 308-nm excimer laser

description: Introduction: Among the spectrum of mycosis fungoides (MF), poikilodermatous MF (PMF) is a rare clinical variant of patch-stage MF, which is characterized by cutaneous atrophy, mottled-reticular pigmentation, and telangiectasia. Given its favorable prognosis, ultraviolet (UV) light therapy, such as narrowband UVB (NB-UVB), is commonly employed for the treatment of PMF. Notably, the 308-nm excimer laser emits high-energy monochromatic light with a wavelength close to the NB-UVB peak. Case presentation: Herein, we report a case of PMF successfully treated with the 308-nm excimer laser.
Conclusion: There have been no English-language case reports describing the use of excimer laser treatment for PMF, and this is the first English report that suggests the usefulness of the 308-nm excimer laser for the treatment of PMF, which is one of the clinical variants of patch-stage of MF.
DOI: 10.6084/m9.figshare.28428926.v1
title: Supplementary Material for: Successful treatment of poikilodermatous mycosis fungoides with 308-nm excimer laser

description: Introduction: Among the spectrum of mycosis fungoides (MF), poikilodermatous MF (PMF) is a rare clinical variant of patch-stage MF, which is characterized by cutaneous atrophy, mottled-reticular pigmentation, and telangiectasia. Given its favorable prognosis, ultraviolet (UV) light therapy, such as narrowband UVB (NB-UVB), is commonly employed for the treatment of PMF. Notably, the 308-nm excimer laser emits high-energy monochromatic light with a wavelength close to the NB-UVB peak. Case presentation: Herein, we report a case of PMF successfully treated with the 308-nm excimer laser.
Conclusion: There have been no English-language case reports describing the use of excimer laser treatment for PMF, and this is the first English report that suggests the usefulness of the 308-nm excimer laser for the treatment of PMF, which is one of the clinical variants of patch-stage of MF.
DOI: 10.6084/m9.figshare.28428929
title: Supplementary Material for: Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study

description: Introduction
A healthy lifestyle is considered to be an important factor for healthy aging. Kneipp therapy (KT) includes a combination of hydrotherapy, herbal medicine, mind-body medicine, physical activities and healthy nutrition. In this study, we investigated the effectiveness of KT care on activities of daily living, health and quality of life in residents of nursing homes.
Methods
We conducted a prospective, two-armed comparative observational study to compare matched nursing homes with KT (Kneipp group) vs. nursing homes with common preventive interventions (control group) over a 12-month period.. Outcome measures included activities of daily living (Barthel Index), cognition (Mini-Mental State Examination (MMSE)) and quality of life (QUALIDEM; Short-Form 12 (SF-12)).
Results
We included 7 nursing homes (n=105 residents) for the Kneipp group and 6 nursing homes (n=69) as control. Except for Barthel Index, there were no time point dependent differences between the groups. The Barthel Index showed a smaller difference from baseline in the control group (mean diff. 0.94, 95%CI [-1.94; 3.82]) compared to Kneipp group (- 4.08, 95%CI [-6.46; -1.69]; p=0.009) after 6 months.
Pooled over the timepoints the SF-12 mental health sum scale exhibited a smaller difference from baseline in the Kneipp group (-1.3, 95%CI [-3.6; 0.9]) compared to the control group (-3.8, 95%CI [-6.3; -1.4]; p=0.027). Furthermore, the MMSE sumscore, decreased less in the Kneipp group compared to control (-1.1, 95%CI [-2.2, -0.1]; p=0.033) after 12 months.
A post hoc comparison of residents from both groups who received at least 30 preventive interventions monthly exhibited better values for QUALIDEM items “social relations”, “social isolation” and “feeling at home”.
Conclusion
This comparative observational study showed only small differences in outcome measures between the groups. The frequency of treatments may positively influence social components of behavior and well-being in residents. High-quality pragmatic randomized trials are needed for further investigations.
DOI: 10.6084/m9.figshare.28428929.v1
title: Supplementary Material for: Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study

description: Introduction
A healthy lifestyle is considered to be an important factor for healthy aging. Kneipp therapy (KT) includes a combination of hydrotherapy, herbal medicine, mind-body medicine, physical activities and healthy nutrition. In this study, we investigated the effectiveness of KT care on activities of daily living, health and quality of life in residents of nursing homes.
Methods
We conducted a prospective, two-armed comparative observational study to compare matched nursing homes with KT (Kneipp group) vs. nursing homes with common preventive interventions (control group) over a 12-month period.. Outcome measures included activities of daily living (Barthel Index), cognition (Mini-Mental State Examination (MMSE)) and quality of life (QUALIDEM; Short-Form 12 (SF-12)).
Results
We included 7 nursing homes (n=105 residents) for the Kneipp group and 6 nursing homes (n=69) as control. Except for Barthel Index, there were no time point dependent differences between the groups. The Barthel Index showed a smaller difference from baseline in the control group (mean diff. 0.94, 95%CI [-1.94; 3.82]) compared to Kneipp group (- 4.08, 95%CI [-6.46; -1.69]; p=0.009) after 6 months.
Pooled over the timepoints the SF-12 mental health sum scale exhibited a smaller difference from baseline in the Kneipp group (-1.3, 95%CI [-3.6; 0.9]) compared to the control group (-3.8, 95%CI [-6.3; -1.4]; p=0.027). Furthermore, the MMSE sumscore, decreased less in the Kneipp group compared to control (-1.1, 95%CI [-2.2, -0.1]; p=0.033) after 12 months.
A post hoc comparison of residents from both groups who received at least 30 preventive interventions monthly exhibited better values for QUALIDEM items “social relations”, “social isolation” and “feeling at home”.
Conclusion
This comparative observational study showed only small differences in outcome measures between the groups. The frequency of treatments may positively influence social components of behavior and well-being in residents. High-quality pragmatic randomized trials are needed for further investigations.
DOI: 10.6084/m9.figshare.28428932
title: Supplementary Material for: A case of a SMARCB1 (INI1)-deficient intrathoracic neoplasm that did not respond to chemotherapy for non-small cell lung cancer and rapidly progressed

description: SMARCB1 (INI1)-deficient intrathoracic neoplasms are rare and highly malignant. We report a case of a patient with this tumor who was initially diagnosed with non-small cell lung cancer and whose disease rapidly progressed to death despite chemotherapy. A man in his 60s was diagnosed with a mass exceeding 10 cm in the lower lobe of the right lung and a right pleural effusion on the first examination. Transbronchial biopsy of the primary lesion revealed a tumor with rhabdoid features, which was diagnosed as an undifferentiated malignant neoplasm. Clinically, the patient was diagnosed with non-small cell lung cancer and was treated with carboplatin, nab-paclitaxel, durvalumab, and tremelimumab. However, at the end of the second course, there was rapid disease progression. Based on a pathological review, the tumor was considered a SMARCB1-deficient intrathoracic neoplasm. Although we considered further treatment, his general condition deteriorated, and he died about two months after his first visit. This disease is rare, and we believe that it is necessary to disseminate the concept of this disease and accumulate knowledge to establish a treatment.
DOI: 10.6084/m9.figshare.28428932.v1
title: Supplementary Material for: A case of a SMARCB1 (INI1)-deficient intrathoracic neoplasm that did not respond to chemotherapy for non-small cell lung cancer and rapidly progressed

description: SMARCB1 (INI1)-deficient intrathoracic neoplasms are rare and highly malignant. We report a case of a patient with this tumor who was initially diagnosed with non-small cell lung cancer and whose disease rapidly progressed to death despite chemotherapy. A man in his 60s was diagnosed with a mass exceeding 10 cm in the lower lobe of the right lung and a right pleural effusion on the first examination. Transbronchial biopsy of the primary lesion revealed a tumor with rhabdoid features, which was diagnosed as an undifferentiated malignant neoplasm. Clinically, the patient was diagnosed with non-small cell lung cancer and was treated with carboplatin, nab-paclitaxel, durvalumab, and tremelimumab. However, at the end of the second course, there was rapid disease progression. Based on a pathological review, the tumor was considered a SMARCB1-deficient intrathoracic neoplasm. Although we considered further treatment, his general condition deteriorated, and he died about two months after his first visit. This disease is rare, and we believe that it is necessary to disseminate the concept of this disease and accumulate knowledge to establish a treatment.
DOI: 10.6084/m9.figshare.28428935
title: Supplementary Material for: National trends in asthma prevalence among adolescents in South Korea, 2007–2023: a national representative serial study

description: Background: Although previous studies have analyzed trends in asthma prevalence among adolescents before and during the COVID–19 pandemic, research specifically investigating asthma prevalence after the pandemic is lacking. Therefore, this study aims to analyze the long-term trends and the impact of the COVID-19 pandemic on the prevalence of asthma among Korean adolescents.
Methods: Data were collected from a nationwide representative study (Korean Youth Risk Behavior Web-based Survey), conducted among adolescents aged 12 to 18 years from 2007 to 2023. To assess the impact of the COVID–19 pandemic, data were divided into three periods: pre-pandemic (2007–2019), intra-pandemic (2020–2022), and post-pandemic (2023). The prevalence of current asthma and variations in asthma prevalence across the pre-, intra-, and post-pandemic periods were analyzed using weighted linear regression and logistic models with 95% confidence intervals (CIs).
Results: A total of 1,087,236 participants (559,840 males [51.49%]) were included in the analysis from 2007 to 2023. The weighted asthma prevalence exhibited slight fluctuations prior to the pandemic, with no notable overall changes. However, a substantial decline was observed during the intra-pandemic period compared to pre-pandemic (βdiff intra- versus pre-pandemic, -0.11 [95% CI, -0.12 to -0.09]), followed by a slight weakening in the post-pandemic period (βdiff post- versus intra-pandemic, 0.07 [95% CI, 0.03–0.10]). This trend persisted when analyzed by sex, with males exhibiting a higher prevalence than females throughout the entire period (versus females: weighted odds ratio, 1.31 [95% CI, 1.29–1.34]). Additionally, prior to the pandemic, the prevalence of asthma was higher among students in grades 7–9. However, after the pandemic began, students in grades 10–12 showed higher prevalence rates than their younger counterparts. The prevalence was also higher among adolescents who were overweight or obese, smoked, lived in facilities, had low household income, consumed fast food more than five times a week, experienced high stress levels, and reported low subjective recovery from fatigue.
Conclusions: This comprehensive study suggests that the prevalence of asthma among adolescents varies with age and may be affected by the COVID–19 pandemic. Additionally, it identifies key factors contributing to asthma vulnerability, highlighting the importance of developing age-specific policies and targeted interventions for these at-risk groups.
DOI: 10.6084/m9.figshare.28428935.v1
title: Supplementary Material for: National trends in asthma prevalence among adolescents in South Korea, 2007–2023: a national representative serial study

description: Background: Although previous studies have analyzed trends in asthma prevalence among adolescents before and during the COVID–19 pandemic, research specifically investigating asthma prevalence after the pandemic is lacking. Therefore, this study aims to analyze the long-term trends and the impact of the COVID-19 pandemic on the prevalence of asthma among Korean adolescents.
Methods: Data were collected from a nationwide representative study (Korean Youth Risk Behavior Web-based Survey), conducted among adolescents aged 12 to 18 years from 2007 to 2023. To assess the impact of the COVID–19 pandemic, data were divided into three periods: pre-pandemic (2007–2019), intra-pandemic (2020–2022), and post-pandemic (2023). The prevalence of current asthma and variations in asthma prevalence across the pre-, intra-, and post-pandemic periods were analyzed using weighted linear regression and logistic models with 95% confidence intervals (CIs).
Results: A total of 1,087,236 participants (559,840 males [51.49%]) were included in the analysis from 2007 to 2023. The weighted asthma prevalence exhibited slight fluctuations prior to the pandemic, with no notable overall changes. However, a substantial decline was observed during the intra-pandemic period compared to pre-pandemic (βdiff intra- versus pre-pandemic, -0.11 [95% CI, -0.12 to -0.09]), followed by a slight weakening in the post-pandemic period (βdiff post- versus intra-pandemic, 0.07 [95% CI, 0.03–0.10]). This trend persisted when analyzed by sex, with males exhibiting a higher prevalence than females throughout the entire period (versus females: weighted odds ratio, 1.31 [95% CI, 1.29–1.34]). Additionally, prior to the pandemic, the prevalence of asthma was higher among students in grades 7–9. However, after the pandemic began, students in grades 10–12 showed higher prevalence rates than their younger counterparts. The prevalence was also higher among adolescents who were overweight or obese, smoked, lived in facilities, had low household income, consumed fast food more than five times a week, experienced high stress levels, and reported low subjective recovery from fatigue.
Conclusions: This comprehensive study suggests that the prevalence of asthma among adolescents varies with age and may be affected by the COVID–19 pandemic. Additionally, it identifies key factors contributing to asthma vulnerability, highlighting the importance of developing age-specific policies and targeted interventions for these at-risk groups.
DOI: 10.15468/dl.kanuhg
title: Occurrence Download

description: A dataset listing the 11 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "Geometry POLYGON((115.55155 35.654,127.97205 35.654,127.97205 41.56311,115.55155 41.56311,115.55155 35.654))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Nemertea"
 ]
}

 The dataset's 11 records were derived from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002765-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.