cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2009.1734
title: HLA-B and HLA-C loci genetic polymorphism as a marker of severe cutaneous adverse reactions in Thai patients on allopurinol

description: There were two main purposes in this present study; first, to investigate the causative drugs, the prevalence and mortality rates related to severe cutaneous adverse reactions (SCAR) during 2003-2007 using retrospective data collected from electronic database of Adverse Drug Reaction Monitoring Center and Siriraj Computer Center, Siriraj Hospital, Bangkok; second, to determine the association between HLA-B[superscript *]5801 and HLA-Cw[superscript *]0302 alleles to SCAR induced by allopurinol in Thai patients using case-control study. There were 25 case patients who experienced allopurinol induced SCAR, 9 case patients who experienced other cutaneous adverse reaction from allopurinol and 48 allopurinol tolerant controls participate in the study. SCAR was found in 136 patients. The prevalence of SJS, TEN and HSS were most often found in patients treated with carbamazepine (3.26 per 1,000 patients), allopurinol (0.21 per 1,000 patients) and phenytoin (2.64 per 1,000 patient), respectively. Mortality rates of SJS, TEN and HSS were 6.90%, 50.0% and 12.82% respectively. Allopurinol revealed the highest mortality rate. HLA-B[superscript *]5801 and HLA-Cw[superscript *]0302 alleles were found in all 25 cases (100%) of patient with SCAR, only 7 controls (14.58%) of allopurinol tolerant patients have HLA-B*5801 and HLA-Cw[superscript *]0302 alleles. Risk of SCAR in patients with HLA-B*5801 and HLA-Cw[superscript *]0302 alleles was 282 times higher (95%CI 15.45 to 5153.83, P-value &lt; 0.001). This study was the first that reported the presence of HLA-B[superscript *]5801 and HLA-Cw[superscript *]0302 alleles in all patients who experienced exfoliative dermatitis from allopurinol. Model to predict the adverse drug reactions from allopurinol using logistic regression demonstrated its association to three main factors; HLA-B[superscript *]5801 allele, female gender and underlying of diabetes mellitus.
DOI: 10.14457/cu.the.2009.1735
title: Chemosenors based on quinone and boronic acid and their complexation properties

description: Six A-D-A sensors containing naphthoquinone imidazole boronic acid were synthesized including protonated derivatives, o-HNQB, m-HNQB and p-HNQB and methylated derivatives, o-MNQB, m-MNQB and p-MNQB. Complexation properties of all sensors were studied by fluorescence spectrophotometry. All protonated sensors showed quenching of fluorescence intensity at λ[subscript emiss] = 554 nm due to an inverse PET character upon the deprotonation by basic anions such as F⁻, OAC⁻ and CN⁻. Anion binding properties of methylated sensors were carried out in four solvent systems: DMSO, DMSO:H₂O (1:1), DMSO:HEPES pH 7.4 (1:1) and CTAB micelles. The appearance of a new emission band at 460 nm was observed in the presence of F⁻, CN⁻ and OH⁻ corresponding to the disturbance of an ICT efficiency of the sensor upon changes in hybridization changes at the boron center from sp² to sp³. In the DMSO system, p-MNQB preferred binding F⁻ whereas in aqueous solution m-MNQB and p-MNQB showed the selectivity toward CN⁻. In the CTAB micellar system, m-MNQB and p-MNQB showed promising characteristics of fluorescence probes in term of selectivity and limit of detection for micromolar cyanide detection in water. Two anthraquinone imidazole boronic based sensors, HAQB and MAQB were synthesized. The saccharide binding properties were studied using fluorescence spectrophotometry. At pH 8.5, affinity trends of both sensors were D-fructose &gt; D-galactose &gt; D-mannose &gt; D-glucose
DOI: 10.14457/cu.the.2009.1736
title: Plantwide control structure design of ethyl benzene using fixture point theorem

description: Chemical process control structure was studied widely to optimized economic under various process object constrains and environment safety. This research is applied "Fixture point theorem" to ethyl benzene process to design a new plantwide control structures that be compared with Luyben (2002). The principle of the fixture point theorem is the most disturbed variables were affected by manipulated variables or disturbances change should be precedence consideration. We selected two of controlled variables and three control structures were designed and compared. The dynamic behaviors of designed control structures were illustrated whether mainpulated variables change and the performance were presented in IAE value. The design control structure had a good performance and energy use reduction in the process. This research establishes that the Wongsri's procedure lead to a good performance plantwide control system
DOI: 10.14457/cu.the.2009.1737
title: Numerical methods for mean-reverting square root processes with jumps

description: We study three numerical methods: Euler-Maruyama method, compensated split-step backward Euler method, and jump-adapted Euler method by numeri- cally investigating on their performance as well as accuracy in solving the mean- reverting square root process with jumps in weak sense. Rigorous error bounds in weak sense for Euler-Maruyama and compensated split-step backward Euler methods will also be provided
DOI: 10.14457/cu.the.2009.1738
title: Optimal glowth condition for diatom Entomoneis sp. cultivation in photobioreactor

description: The optimal conditions for the growth of a diatom Entomoneis sp. were investigated in a 2.5 L bubble column. A modified standard F/2 medium was selected as a standard medium. Silicon was the limiting factor for the growth of this alga, and a periodic addition of Si (fixed 6.7 mg L[superscript -1]) at the cultivating Days 3, 4 and 5 could, to some extent, overcome this limitation. The light intensity for the best growth was found at around 270 mumol photons m[superscript -2]s-[superscript -1] at the aeration rate (in terms of superficial velocity) of 0.5 cm s[superscript -1]. At this condition, the alga exhibited the highest growth rate of 41.39 x10[superscript 4] cells mL-1 and a maximum specific growth rate of 0.48 d-1. The cultivation of Entomoneis sp. in the 17 L flat plate airlift photobioreactor was exposed to sunlight during the day time and fluorescent light during the night. The light intensity from fluorescent light was about 43 mumol photon m[superscript -2] s[superscript -1]. The aeration was supplied at usg of 0.5 cm s-1 and this obtained a maximum specific growth rate of 0.59 d[superscript -1] with a maximum cell concentration of 31.05×104 cells mL[superscript -1] in a batch culture. A semi-continuous culture could be achieved where the 3-day harvesting interval provided the maximum cell concentration of 37.49x10[superscript 4] cell mL[superscript -1]and the specific growth rate of 0.54 d[superscript -1]. Lastly, the pre-evaluation of the effect of CO[subscript 2] for the cultivation of Entomoneis sp. operated with CO[subscript 2] from 1 to 7% in 17 L flat plate airlift in semi-continuous mode demonstrated that the best growth occurred at 5% CO[subscript 2] where the maximum cell concentration and specific growth rate were 53.89x10[superscript 4] cell mL[superscript -1] and 0.68 d-1, respectively.
DOI: 10.14457/cu.the.2009.1739
title: Control structure design for phenol hydrogenation to cyclohexanone process

description: For industries, material and energy recycle are beneficial in economic aspect. However, they make processes more complex. So the good control structure is necessary and is the important thing in order to maintain process operation, safety and product quality. In this research, control structures for phenol hydrogenation to cyclohexanone process consisting of many recycle streams and energy integration is designed. Procedure of Luyben (1998) and procedure of Wongsri (2009) are applied in design. This study use software HYSYS to simulate phenol hydrogenation to cyclohexanone process at steady state and dynamic. Designed control structures using procedure of Luyben (1998) and designed control structures using procedure of Wongsri (2009) can also design the same control structures. The four control structures are designed by using these two procedures. Then all designed control structures are evaluated the dynamics performance and are compared with each others. The result shows that all designed control structures can eliminate disturbances, can maintain product quality and can achieve process constraints. In sum, the plantwide control procedure of Wongsri (2009) can design the good performance control system.
DOI: 10.14457/cu.the.2009.1740
title: Searching for bioactive compounds from Boesenbergia pandurata (Roxb.) Schltr. and Kaempferia parviflora Wall Ex. Baker using ∆zdsl mutant yeast-based assay

description: To search for bioactive compound isolated from Thai medicinal plants using ∆zdsl yeast-based assay, a unique positive-drug screening system. In the preliminary screening, four crude extracts of 50 medicinal herbs (Andrographis paniculata, B. pandurata, K. parviflora and Syzygium cinereum) exhibited strong positive results on calcium signaling inhibition in the assay. Two potent positive plants of Zingiberaceae family, B. pandurata and K. parviflora, were chosen for further fractionation followed by activity guided yeast-based assay. The CH2Cl2 extracts of these plants were isolated by chromatographic techniques and seven known flavonoid compounds were obtained. Structures of the compounds were elucidated by spectroscopic techniques. Pinostrobin (A), alpinetin (B) and pinostrobin chalcone (C) were isolated from B. pandurata and 5-hydroxy-3,7-dimethoxyflavone (D), 5-hydroxy-7-methoxyflavone (E), 5-hydroxy-3,7,4'-trimethoxyflavone (F) and 5,7-dimethoxy-flavone (G) were found in K. parviflora. Compound A and D exhibited strong positive and non-toxic to the yeast cells so they were chosen for further biological studies. For the study of A and D on finding the target molecules in the calcium signaling pathway, the target molecules of these two compounds were Swe1 (ortholog of mammalian Wee1) and MCK1 (homolog of mammalian GSK3), respectively. The two compounds exhibited moderate anti-inflammatory activity on carrageenin-induced paw edema in rat with % inhibition values of 43.71 and 42.2, respectively. Moreover, Compound A also exhibited the cytotoxicity with MTT assay on Jukat, A375 and Kato III human cancer cell lines with IC50 value of 56, 67 and 86 µM, respectively. Compound D moderately inhibited 6 strains of Helicobacter pylori with the MIC value of 0.84-6.71 µM
DOI: 10.14457/cu.the.2009.1741
title: Factors influencing health behaviors of elders in Mueang district, Roi Et province, Thailand

description: To study health behavior of the elderly in Mueang District, Roi Et Province, concerning exercise, diet, self care during illnesses and stress management, to describe each personal attribution factor, such as, gender, age, educational background, marital status, income, income sufficiency, main source of income and personal illness) by taking into consideration health service system and social environment and to determine factors influencing health behaviors. It was a cross-sectional study with systematic sampling among 430 samples. Data collection was in December 2009. Descriptive statistics was employed (frequency, percentage, mean, standard deviation) while Chi-Square test was used to find out the factors associated with their health behaviors . The results found that majority of samples was females (58.6%),aged between60E65 years old (40.5%) ,finished primary school (79.8%), married (63.7%) ,with monthly household income less than 5,000 baht (47.9%), had sufficient income but not enough for saving (41.9%), earned their own income(96.3%), had personal illnesses (57.2%),such as diabetes (46.1%), with consistent follow-up of their chronic disease(99.3%).In regards to their health behaviors, the result revealed that diet behavior was on good level(Î§-bar = 2.68, S.D. = 0.25); exercise behavior was on fair level (Î§-bar = 2.13, S.D. = 0.60); self care behavior was on good level(Î§-bar = 2.69, S.D. = 0.39) and stress management behavior was on good level (Î§-bar = 2.37, S.D. = 0.41). Factors positively associated with health behaviors of elderly were as follows: age and personal illnesses with diet behavior at the statistical significance level of 0.05 (p=0.048,0.008 respectively); gender, educational background and income sufficiency with exercise behavior at the statistical significance level of 0.05 (p=0.002,0.016,&lt;0.001 respectively); marital status with self care behavior at the statistical significance level of 0.05 (p=0.032); gender, educational background and income sufficiency with stress management behavior at the statistical significance level of 0.05 (p=0.045,0.024,0.001 respectively). In the future, there should be the study on health behavior of elders in qualitative method and on other factors that have association with health behavior of elderly.
DOI: 10.5281/zenodo.3379847
title: Vascular Territory template and atlases in MNI space

description: <strong>Data</strong> Sixteen subjects (mean age (sd): 69.6 (8.2); 37.5% female) were recruited to generate a high-resolution template. The cohort consists of twelve stroke-free, non-demented patients with the sporadic form of cerebral amyloid angiopathy (CAA), and similarly-aged healthy controls (n=4). Each participant underwent high-resolution MRI with a Siemens Magnetom Prisma 3T scanner (using a 32-channel head coil) as part of a separate study. The standardized protocol included a Multiecho T1-weighted (voxel size: 1x1x1 mm<sup>3</sup>; Repetition Time [TR]: 2510 ms), a 3D-FLAIR (voxel size: 0.9x0.9x0.9 mm<sup>3</sup>; TR: 5000 ms; TE: 356 ms), and a T2-weighted Turbo Spin Echo (voxel size: 0.5x0.5x2.0 mm<sup>3</sup>; TR: 7500 ms; TE: 84 ms) sequence. Scans were manually assessed to ensure no gross pathology was present, such as hemorrhage or silent brain infarcts. <strong>Template and territorial map creation</strong> We employed Advanced Normalization Tools (ANTs) for image processing (Avants et al., 2010, 2011) for creating a brain template based on multimodal information using T1, T2 and 3D-FLAIR sequences. After template creation, we smoothed the resulting templates (FSL; Gaussian smoothing, sigma = 1) and registered the resulting templates into MNI space, again using ANTs (Avants et al., 2011). Vascular territories were outlined on the right hemisphere in the T1-weighted atlas image and contain anatomically validated ACA, MCA, and PCA territories supratentorially. The right hemispheric map was then mirrored onto the left hemisphere to create a full-brain vascular territory map, which was manually assessed and corrected where necessary. For more details, please see the original publication that utilized the template. If you utilize this template, please also cite Schirmer, Markus D., et al. "Spatial signature of white matter hyperintensities in stroke patients." <em>Frontiers in neurology</em> 10 (2019): 208. https://doi.org/10.3389/fneur.2019.00208 <strong>Files</strong> <strong>FLAIR template</strong>: caa_flair_in_mni_template_smooth.nii.gz<br> <br> <strong>FLAIR template after brain extraction and intensity normalization</strong>: caa_flair_in_mni_template_smooth_brain_intres.nii.gz<br> <br> <strong>T1 template</strong>: caa_t1_in_mni_template_smooth.nii.gz 27.7 Mb<br> <br> <strong>T2 template</strong>: caa_t2_in_mni_template_smooth.nii.gz 27.7 Mb<br> <br> <strong>Vascular territory map</strong>: mni_vascular_territories.nii.gz
description: This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 753896 (M.D. Schirmer). This study was supported by the NIH-National Institute of Neurological Disorders and Stroke (K23NS064052, R01NS082285, and R01NS086905), American Heart Association/Bugher Foundation Centers for Stroke Prevention Research, and Deane Institute for Integrative Study of Atrial Fibrillation and Stroke.
DOI: 10.14457/cu.the.2009.1742
title: Survey of influenza A viruses in live bird markets in Thailand

description: Live bird markets (LBMs) are places where the birds are sold as pet or poultry meat. LBMs settings usually appear with dense population, multiple species and different sources in order to supply the customers demand. With these conditions, many diseases can transmit and spread within LBMs while some species such as waterfowls and ducks are known as reservoir of influenza A virus entering LBMs everyday. In this study, we conducted a 12 months survey of influenza A virus in 10 LBMs in Thailand, 2009. A total of 5,304 samples from 2,652 animals were collected and tested for influenza A virus. Influenza A viruses subtype H4N6 (n=2), H4N9 (n=1) and H10N3 (n=16) were identified with 0.36% positive (19/5,304). All influenza A isolates were collected from Muscovy ducks in a market located in Bangkok. In Thailand, none of these 3 influenza A subtypes had ever been reported in the country. In this study, H5N1 subtype was not detected which concordant with the report of none influenza A H5N1 outbreak in Thailand during 2009. Our results showed that two influenza A subtypes (H4N6 and H4N9) can be isolated from the same bird at the same collecting time. This result suggested that the reassortment of influenza A virus can occurs in LBMs. In summary, survey of influenza A virus in LBMs is very important and can serves as an early warning system for viral reassortment and spreading of the virus to various avian and mammal species which can cause economical losses and public health problems in the future.
DOI: 10.14457/cu.the.2009.1743
title: Method development for the determination of trace heavy metals by sequential injection-anodic stripping voltammetry using bismuth-coated screen printed carbon nanotube electrode

description: In this research, a method for the simultaneous determination of Pb (II), Cd (II), and Zn (II) at low mug L[superscript -1] concentration levels by sequential injection analysis-anodic stripping voltammetry (SIA-ASV) using screen-printed carbon nanotube electrode (SPCNTE) was developed. A bismuth film was prepared by in situ plating of bismuth on the screen-printed carbon nanotubes electrode. Operational parameters such as ratio of carbon nanotubes to carbon ink, bismuth concentration, deposition time and flow rate during preconcentration step were optimized. Under the optimal conditions, the linear ranges were found to be 2-100 L[superscript -1]for Pb (II) and Cd (II), and 12-100 L[superscript -1]for Zn (II). The limits of detection (Sbl/S=3) were 0.2 μg L-1 for Pb (II), 0.8 L[superscript -1]for Cd (II) and 11 L[superscript -1]for Zn (II). The measurement frequency was found to be 10-15 stripping cycle h-1. The present method offers high sensitivity and high throughput for on-line monitoring of trace heavy metals. The practical utility of our method was also demonstrated with the determination of Pb (II), Cd (II), and Zn (II) by spiking procedure in herb samples.
DOI: 10.14457/cu.the.2009.1744
title: Disaster diplomacy : a case study of the tripartite core group's post-nargis humanitarian assistance in Myanmar

description: On 2 May 2008 the devastating Cyclone Nargis hit Myanmar, causing over 140,000 deaths and affecting about 2.4 million people in the country. Despite the desperate situation, the Government of Myanmar refused the humanitarian assistance offered by international development organizations and Western governments. This act caused the international community to formulate unconventional ways in order to bring relief into Myanmar. They attempted to apply the Responsibility to Protect principle but failed, and later on used disaster diplomacy tactics by utilizing ASEAN as a mediating agent to build dialogue between Myanmar and the humanitarian community. This ASEAN-led mechanism was operated under the establishment of the coordinating body called the Tripartite Core Group (TCG) aiming to bring aid into Myanmar. This thesis uses the disaster diplomacy framework to address the impact of Cyclone Nargis on the two-decades-long tension between the Government of Myanmar and the international community. The TCG, with the mediating support by the ASEAN, was seen by many observers as an opportunity to revitalize and improve this relationship. Apart from facilitating aid, the TCG was expected to help breaking down Myanmar’s suspicion about the West’s agenda and help the Government of Myanmar realize that the humanitarian community had no hidden political objective on its aid agenda. Beyond evaluating the work of the TCG in the above light, the thesis also aims to examine the achievements of the ASEAN and the UN as to whether they were able to efficiently meet the TCG’s objectives regarding humanitarian aid and their ability to change the perception, behavior, approach and objectives of Myanmar. The study also identifies the gaps, challenges and the opportunities faced by the group to provide efficient and meaningful emergency response to Myanmar
DOI: 10.14457/cu.the.2009.1745
title: Bioactive compounds of endophytic fungi from Andrographis paniculata (Burm. F.) Wall. ex Nees., Chromolaena odoratum (L.) R. M. King & H. Rob. and Stemona sp.

description: Exserohilum rostratum, an endophytic fungus, from Stemona sp. produced a novel compound, 11-hydroxymonocerin (2), and two known compounds -- monocerin (1) and 12-hydroxymonocerin (3). Compounds 1 and 2 were derivatized to obtain 8 new compounds: 8-acetylmonocerin (4), diacetylmonocerin (5), 8-benzoylmonocerin (6), 8-methylmonocerin (7), 5-bromomonocerin (8), 8-hydroxy-6,7-dimethoxy-3-(pentan-2´-yl-acetate)-isocoumarin (9), 11-Oxomonocerin (10) and 11-carbonylmonocerin (11). Compounds 1, 2, 4, 5, 6 and 10 have specific activity against Plasmodium falciparum K1 strain with IC₅₀ = 0.69, 7.42, 0.82, 9.1, 7.85 and 13.4 µM, respectively. Endophytic fungal strains from Andrographis paniculata produced three known compounds: N-Phenetyl-acetamide (12), and tryptophol (13) and indole-3-acetamide (14). Endophytic fungal strains from Chromolaena odoratum, produced two known compounds: cytochalasin D (15) and cytochalasin H (16)
DOI: 10.14457/cu.the.2009.1746
title: Going the wrong way ? trends and motivation in the North-South cross-border movement of tertiary students : the case study of European students in Thailand

description: Cross-border movements are the most visible outcome of the internationalisation of higher education. Due to the processes of globalisation, and the internationalisation of higher education by higher education institutes and nation-states, cross-border movements by tertiary students have increased dramatically over the last decades. Up to date, most studies in this field have focused on the South-North movement of students. This pioneering study however, researches the North-South movements at the example of European students in Thailand. Within this frame, this study aims to answer two questions: What are the push- and pull factors for European students to move to Thailand for study-purposes and what are the possible benefits for Thailand from hosting European students?. In order to answer these two questions, a detailed survey of 26 European exchange and degree students from different European countries studying in Thailand has been conducted. The results of these surveys have shown that whereas for most students, social and environmental factors such as the different lifestyle and culture, the weather and travel or a general feeling of “getting away from home” have dominated, for other students, who often already live in Thailand, educational and financial factors are leading. The benefits for Thailand are on the one hand the tangible immediate financial gains from the expenses study fees of the students. On the other hand however, intangible benefits such as the transfer of knowledge and skills, inter-cultural ties and clusters of knowledge can develop through people-to-people links. Additionally, it has been shown in this study that foreign students can develop a very strong bond to the host country. Through this bond, students can act as “ambassadors” for the host country, in the long run benefitting the host on an economic, business or official level