cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30327262
title: Supplementary Material for: Comparative Effectiveness of Mycophenolate Mofetil and Tacrolimus as a Second-line Therapy for Autoimmune Hepatitis: A Systematic Review and Meta-Analysis

description: Objective: Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease that usually responds to corticosteroids ± azathioprine (AZA). However, some patients are intolerant or refractory to first-line therapy and require second-line immunosuppression. Mycophenolate mofetil (MMF) and tacrolimus (TAC) are commonly used alternatives, although comparative evidence is limited. This systematic review and meta-analysis evaluated the efficacy and safety of MMF and TAC in adult AIH patients who failed first-line therapy. Methods: A systematic search of six databases identified 16 eligible studies (n = 705), including retrospective cohorts and one case series. Study quality was assessed using the Newcastle–Ottawa Scale and the MMS (methodological quality and synthesis of case series and case reports) tool. Results: Biochemical remission was achieved in 56% of MMF-treated patients, rising to 66% with ≥6 months follow-up. TAC showed a pooled remission rate of 66%, increasing to 67% when defined by transaminase normalization. MMF was particularly effective in azathioprine-intolerant patients, while TAC showed better outcomes in steroid-refractory patients. Adverse events differed: MMF was most often associated with gastrointestinal intolerance, whereas TAC was linked to tremor, hypertension, diabetes, and renal impairment. However, statistical analysis showed wide confidence intervals, and there was considerable heterogeneity across studies. Conclusion: Both MMF and TAC are effective second-line therapies for AIH. MMF appears safer and better tolerated in azathioprine-intolerant patients, while tacrolimus showed a modest advantage in efficacy over mycophenolate in steroid-refractory cases. Given the limitations of current evidence, including small sample sizes, heterogeneity, and lack of randomized controlled trials, treatment choice should be individualized until higher-quality data are available.
DOI: 10.6084/m9.figshare.30327262.v1
title: Supplementary Material for: Comparative Effectiveness of Mycophenolate Mofetil and Tacrolimus as a Second-line Therapy for Autoimmune Hepatitis: A Systematic Review and Meta-Analysis

description: Objective: Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease that usually responds to corticosteroids ± azathioprine (AZA). However, some patients are intolerant or refractory to first-line therapy and require second-line immunosuppression. Mycophenolate mofetil (MMF) and tacrolimus (TAC) are commonly used alternatives, although comparative evidence is limited. This systematic review and meta-analysis evaluated the efficacy and safety of MMF and TAC in adult AIH patients who failed first-line therapy. Methods: A systematic search of six databases identified 16 eligible studies (n = 705), including retrospective cohorts and one case series. Study quality was assessed using the Newcastle–Ottawa Scale and the MMS (methodological quality and synthesis of case series and case reports) tool. Results: Biochemical remission was achieved in 56% of MMF-treated patients, rising to 66% with ≥6 months follow-up. TAC showed a pooled remission rate of 66%, increasing to 67% when defined by transaminase normalization. MMF was particularly effective in azathioprine-intolerant patients, while TAC showed better outcomes in steroid-refractory patients. Adverse events differed: MMF was most often associated with gastrointestinal intolerance, whereas TAC was linked to tremor, hypertension, diabetes, and renal impairment. However, statistical analysis showed wide confidence intervals, and there was considerable heterogeneity across studies. Conclusion: Both MMF and TAC are effective second-line therapies for AIH. MMF appears safer and better tolerated in azathioprine-intolerant patients, while tacrolimus showed a modest advantage in efficacy over mycophenolate in steroid-refractory cases. Given the limitations of current evidence, including small sample sizes, heterogeneity, and lack of randomized controlled trials, treatment choice should be individualized until higher-quality data are available.
DOI: 10.6084/m9.figshare.30327265
title: Supplementary Material for: Effectiveness and Safety of Fecal Microbiota Transplantation for Ulcerative Colitis Treatment: A Systematic Review and Meta-Analysis

description: Despite advances in pharmaceuticals, managing ulcerative colitis (UC) remains challenging. Interest in fecal microbiota transplantation (FMT) for UC is growing, but varying formulations and endpoints in trials complicate safety and efficacy assessment. This systematic review and meta-analysis offer a validated, up-to-date overview of FMT’s efficacy and safety in UC. We searched four electronic databases and analyzed only randomized clinical trials (RCT) that investigated the clinical and endoscopic efficacy of FMT in UC, regardless of administration route or dose. Clinical and endoscopic remission was assessed by comparing the odds ratio (OR) and 95% confidence interval (CI). The initial search yielded 6737 studies with 15 meeting inclusion criteria after duplicate removal and screening. The meta-analysis showed clinical remission in 62% receiving FMT vs. 50.5% in controls (OR 2.65; [1.76; 4.00]). The endoscopic response was 42% in the FMT group vs. 22% in controls (OR 2.00; [1.09; 3.68]). Heterogeneity was assessed as low (by I2 index and τ2). Our data show that FMT significantly improves clinical and endoscopic remission rates, offering a promising non-pharmacological option for UC patients unresponsive to conventional treatments. Further prospective studies are needed to optimize the formulation and dosing while also addressing the safety profile of FMT in UC.
DOI: 10.6084/m9.figshare.30327265.v1
title: Supplementary Material for: Effectiveness and Safety of Fecal Microbiota Transplantation for Ulcerative Colitis Treatment: A Systematic Review and Meta-Analysis

description: Despite advances in pharmaceuticals, managing ulcerative colitis (UC) remains challenging. Interest in fecal microbiota transplantation (FMT) for UC is growing, but varying formulations and endpoints in trials complicate safety and efficacy assessment. This systematic review and meta-analysis offer a validated, up-to-date overview of FMT’s efficacy and safety in UC. We searched four electronic databases and analyzed only randomized clinical trials (RCT) that investigated the clinical and endoscopic efficacy of FMT in UC, regardless of administration route or dose. Clinical and endoscopic remission was assessed by comparing the odds ratio (OR) and 95% confidence interval (CI). The initial search yielded 6737 studies with 15 meeting inclusion criteria after duplicate removal and screening. The meta-analysis showed clinical remission in 62% receiving FMT vs. 50.5% in controls (OR 2.65; [1.76; 4.00]). The endoscopic response was 42% in the FMT group vs. 22% in controls (OR 2.00; [1.09; 3.68]). Heterogeneity was assessed as low (by I2 index and τ2). Our data show that FMT significantly improves clinical and endoscopic remission rates, offering a promising non-pharmacological option for UC patients unresponsive to conventional treatments. Further prospective studies are needed to optimize the formulation and dosing while also addressing the safety profile of FMT in UC.
DOI: 10.5281/zenodo.17310079
title: Fungal Spore Counts and Environmental Data collected from BioScout Sensors and Surviellence Network 2024-03-19 to 2025-10-10

description: Overview:

This dataset contains daily spore counts, and spore concentration (spores normalised per cubed metre of air) for each bioscout device in the BioScout x GRDC spore monitoring network. Please visit https://www.bioscout.com.au/grdc if would like access to the network to see the network in real-time.

There is also anonymised device location data to understand the regionality of disease pressure over time.

 

Column Descriptions:




Column Name
Description




spore_concentration

This is the concentration of spores per metre cubed of air sampled for that days' sample. The BioScout SporeScout samplers have a flow metre to measure how much air is taken into the unit in order to better calculate the 'normalised' concentration fo spores between different samples. Each sample may consist of different lengths of time and volumes of air depending on location, the target air particulates to sample, and other environmental impacts that change the optimal sampling period the devices are configured for.




spore_count

The absolute count of observed spores for that particular sample, this doesn't take into account sampling time, it simply sums the total number of spores identified.




date

The date the sample represents.


 

device_name

The device name seen in the grdc network when logging into BioScout.




longitude

The anonymised longitude of the device, these values are relative to the locations of the device but have been obfuscated to help protect property owners.




latitude

The anonymised latitude of the device, these values are relative to the locations of the device but have been obfuscated to help protect property owners.




spore_name

The name of the spore / disease being monitored for this particular count and concentration value.
DOI: 10.5281/zenodo.17288266
title: Mechanical trinary transistors for vibration information identification

description: This is the data from Figures 2(b), 3, and 4 in the article "Mechanical Trinary Transistors for Vibration Information Identification."
DOI: 10.5281/zenodo.17288267
title: Mechanical trinary transistors for vibration information identification

description: This is the data from Figures 2(b), 3, and 4 in the article "Mechanical Trinary Transistors for Vibration Information Identification."
DOI: 10.5517/cc4dym2
title: CCDC 131614: Experimental Crystal Structure Determination

description: Related Article: N.Shankland, A.J.Florence, C.C.Wilson|1997|Acta Crystallogr.,Sect.B:Struct.Sci.|53|176|doi:10.1107/S0108768196010324
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4k8c9
title: CCDC 135760: Experimental Crystal Structure Determination

description: Related Article: A.Yu.Kovalevsky|1999|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|55|9900093|doi:10.1107/S0108270199099023
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4nmq3
title: CCDC 138995: Experimental Crystal Structure Determination

description: Related Article: R. Hauptmann, M. Kondo, S. Kitagawa|2000|Z.Kristallogr.-New Cryst.Struct.|215|169|doi:10.1515/ncrs-2000-0185
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc53rww
title: CCDC 152578: Experimental Crystal Structure Determination

description: Related Article: M.J.Krische, J.-M.Lehn, N.Kyritsakas, J.Fischer, E.K.Wegelius, K.Rissanen|2000|Tetrahedron|56|6701|doi:10.1016/S0040-4020(00)00489-0
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc53rxx
title: CCDC 152579: Experimental Crystal Structure Determination

description: Related Article: M.J.Krische, J.-M.Lehn, N.Kyritsakas, J.Fischer, E.K.Wegelius, K.Rissanen|2000|Tetrahedron|56|6701|doi:10.1016/S0040-4020(00)00489-0
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc59x2f
title: CCDC 158474: Experimental Crystal Structure Determination

description: Related Article: M.Buhl, M.Hakansson, A.H.Mahmoudkhani, L.Ohrstrom|2000|Organometallics|19|5589|doi:10.1021/om000419y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc59x3g
title: CCDC 158475: Experimental Crystal Structure Determination

description: Related Article: M.Buhl, M.Hakansson, A.H.Mahmoudkhani, L.Ohrstrom|2000|Organometallics|19|5589|doi:10.1021/om000419y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4wdr4
title: CCDC 145506: Experimental Crystal Structure Determination

description: Related Article: D.W.Price, M.G.B.Drew, King Kuok Hii, J.M.Brown|2000|Chem.-Eur.J.|6|4587|doi:10.1002/1521-3765(20001215)6:24<4587::AID-CHEM4587>3.0.CO;2-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4wds5
title: CCDC 145507: Experimental Crystal Structure Determination

description: Related Article: D.W.Price, M.G.B.Drew, King Kuok Hii, J.M.Brown|2000|Chem.-Eur.J.|6|4587|doi:10.1002/1521-3765(20001215)6:24<4587::AID-CHEM4587>3.0.CO;2-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4wdt6
title: CCDC 145508: Experimental Crystal Structure Determination

description: Related Article: D.W.Price, M.G.B.Drew, King Kuok Hii, J.M.Brown|2000|Chem.-Eur.J.|6|4587|doi:10.1002/1521-3765(20001215)6:24<4587::AID-CHEM4587>3.0.CO;2-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4wdv7
title: CCDC 145509: Experimental Crystal Structure Determination

description: Related Article: D.W.Price, M.G.B.Drew, King Kuok Hii, J.M.Brown|2000|Chem.-Eur.J.|6|4587|doi:10.1002/1521-3765(20001215)6:24<4587::AID-CHEM4587>3.0.CO;2-6
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc3tpj3
title: CCDC 114065: Experimental Crystal Structure Determination

description: Related Article: Yao-Yu Wang, Qian Shi, Qi-Zhen Shi, Yi-Ci Gao, Xun Hou|2000|Polyhedron|19|891|doi:10.1016/S0277-5387(00)00327-2
description: Related Article: Yao Yu Wang, Qian Shi, Qi Zhen Shi, Yi Ci Gao, Zhong Yuan Zhou|1998|Chin.Chem.Lett.|9|1069|
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15151/esrf-es-2188018985
title: Molecular machines in energy transduction, cellular signaling and defense processes

description: This BAG is composed of 6 working groups from 3 locations (universities of Cologne, Bochum, Duesseldorf),working with both MX and SAXS, the projectsfor this proposal are rather heterogeneous.
Nonetheless, our research focuses on six primary themes: proteins involved in transport processes, immune system function, disease association, industrial enzyme applications, light harvesting, and signaling or fixation processes.
Our research spans a wide range of biological processes, from membrane transport and pathogen defense to enzyme optimization for industrial and environmental applications. By obtaining high-resolution structures of these proteins, we aim to advance our understanding of their functions, paving the way for new therapeutic strategies, biotechnological innovations, and solutions to pressing environmental challenges.
DOI: 10.15151/esrf-es-2210529681
title: Structure of metalloproteins, membrane proteins, filamentous sarcomer proteins, and virus particles

description: Our work focusses on biological nitrogen fixation by Nitrogenase, on metalloenzymes and integral membrane proteins of bacterial and archaeal respiratory systems, as well as on inhibitor development against malignancy-related epigenetic writers, readers and erasers (Andrade/Einsle/Wohlwend), the working mechanism and regulation of medically relevant membrane proteins and complexes and their defects leading to pathologies (Hunte/Wirth), bacterial antibiotic resistance factors and viral and bacterial proteins bound to their targets or inhibitors, and their interactions with glycans (Stehle/Zocher), human S100 proteins involved in nutritional immunity, USP18 enforcing the endogenous antiviral interferon response, and the respiratory complex NQR of V. cholerae (Fritz), DNA Polymerases with artificial substrates (Betz), and on multi-domain components of the sarcomeric filamentous protein titin and their binding to the E3 ubiquitin ligase MuRF1 and the central myosin rod-domain (Mayans).
DOI: 10.5517/cc3h2pb
title: CCDC 103871: Experimental Crystal Structure Determination

description: Related Article: K.M.Shea, K.L.Lee, R.L.Danheiser|2000|Org.Lett.|2|2353|doi:10.1021/ol0061283
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4r1rn
title: CCDC 141321: Experimental Crystal Structure Determination

description: Related Article: L.R.MacGillivray, J.L.Reid, J.A.Ripmeester|2000|J.Am.Chem.Soc.|122|7817|doi:10.1021/ja001239i
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc4r1tq
title: CCDC 141323: Experimental Crystal Structure Determination

description: Related Article: L.R.MacGillivray, J.L.Reid, J.A.Ripmeester|2000|J.Am.Chem.Soc.|122|7817|doi:10.1021/ja001239i
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.29436757
title: New K-feldspar Pb isotope results for Mesozoic arc crust in the Pacific Northwest, U.S.A. and Canada: comparison with the Mojave-Salinia province of southern California and Implications for Baja-BC

description: Measurements of lead isotopic compositions in detrital K-feldspar have been increasingly used as a tool to assess sediment provenance. We compiled a database of previously published Pb isotope data from 700 bedrock K-feldspar samples and 1,423 age-corrected bedrock whole rock samples from western North American igneous and metamorphic bodies. Additionally, we report 66 new K-feldspar Pb isotope data for plutons throughout the Pacific Northwest region of the United States and British Columbia. Results show that the Pb isotope values of plutonic K-feldspar depend on the isotopically juvenile or evolved nature of underlying crust. Samples obtained from the mid Cretaceous – mid Eocene Coast Plutonic Complex, North Cascades, and Intermontane superterrane that occur west of the initial 87Sr/86Sr (Sri) = 0.706 isopleth exhibit a highly restricted 207Pb/206Pb and 208Pb/206Pb values centred upon 0.83 and 2.03, respectively. Conversely, rocks overlying older continental crust further east such as the Middle Jurassic – Late Cretaceous Omineca crystalline belt, Idaho batholith, and Boulder Batholith exhibit far greater variation of Pb isotope values that parallel the 100 Ma isochron calculated from a two-stage Pb evolution model. We demonstrate that Pb isotopic results from the Idaho and Boulder Batholith region can be used to define distinctive subregions for Pb isotopic provenance analysis, and compare these signatures to the Mojave-Salinian batholith of southern California and western Arizona, as these two areas have previously been proposed as source regions for extraregional sediment that was deposited within the Nanaimo Basin during the Campanian – Maastrichtian. Future Pb isotopic analysis of detrital K-feldspar from the Nanaimo Basin of southwestern British Columbia may effectively distinguish between potential extraregional sources separated by thousands of kilometres.