cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5891929.v1
title: Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014

description: <b>Background:</b> The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014. <b>Material and methods:</b> All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence. <b>Results:</b> About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980–1984 to 62.4% in 2010–2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival. <b>Conclusion:</b> This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.
DOI: 10.6084/m9.figshare.5938276
title: Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study

description: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to HPV. An emerging role in treatment response has been attributed to immune cell infiltration in human tumors. In this study, we investigated immune cell infiltration in human SCC of the head and neck region and its relation to overall survival after treatment with surgery (with or without radiotherapy) or concomitant chemo (or cetuximab)-radiotherapy. Paraffin-embedded tumor samples of 136 patients with SCC of the larynx, hypopharynx, oral cavity and oropharynx were processed for immunohistochemical detection of CD3<sup>+</sup> T-cells, CD8<sup>+</sup> cytotoxic T-cells, CD20<sup>+</sup> B-cells and CD163<sup>+</sup> M2 macrophages within the tumor infiltrated area. Clinico-pathological data were analyzed as a function of tumor location and p16-status. Immune cell infiltration was represented as stained area on the whole tumor infiltrated area, compared for the different tumor locations and correlated to patient survival. Patients with oropharynx tumors expressing significant p16 levels (p16-sg) had a 5-year overall survival of 85% compared to 43% for patients with no significant p16 (p16-ns) expression (HR: 0.3 – 95% CI: 0.1–0.6). Median immune cell infiltration (T- and B-lymphocytes) was significantly elevated in p16-sg oropharyngeal tumors, compared to p16-ns oropharyngeal tumors and to all other head and neck tumor locations. No difference in CD163<sup>+</sup> macrophage infiltration was observed across the different patient groups. In the whole population, a high infiltration by CD3<sup>+</sup> T-lymphocytes was associated to a significantly (<i>p</i> = .03; HR: 0.6, 95% CI: 0.4–0.97) better overall survival. Oropharynx cancer with significant p16 expression showed an increased overall survival and elevated T- and B-lymphocyte infiltration, which suggests a prognostic relevance of immune cell infiltration.
DOI: 10.6084/m9.figshare.5938276.v1
title: Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study

description: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to HPV. An emerging role in treatment response has been attributed to immune cell infiltration in human tumors. In this study, we investigated immune cell infiltration in human SCC of the head and neck region and its relation to overall survival after treatment with surgery (with or without radiotherapy) or concomitant chemo (or cetuximab)-radiotherapy. Paraffin-embedded tumor samples of 136 patients with SCC of the larynx, hypopharynx, oral cavity and oropharynx were processed for immunohistochemical detection of CD3<sup>+</sup> T-cells, CD8<sup>+</sup> cytotoxic T-cells, CD20<sup>+</sup> B-cells and CD163<sup>+</sup> M2 macrophages within the tumor infiltrated area. Clinico-pathological data were analyzed as a function of tumor location and p16-status. Immune cell infiltration was represented as stained area on the whole tumor infiltrated area, compared for the different tumor locations and correlated to patient survival. Patients with oropharynx tumors expressing significant p16 levels (p16-sg) had a 5-year overall survival of 85% compared to 43% for patients with no significant p16 (p16-ns) expression (HR: 0.3 – 95% CI: 0.1–0.6). Median immune cell infiltration (T- and B-lymphocytes) was significantly elevated in p16-sg oropharyngeal tumors, compared to p16-ns oropharyngeal tumors and to all other head and neck tumor locations. No difference in CD163<sup>+</sup> macrophage infiltration was observed across the different patient groups. In the whole population, a high infiltration by CD3<sup>+</sup> T-lymphocytes was associated to a significantly (<i>p</i> = .03; HR: 0.6, 95% CI: 0.4–0.97) better overall survival. Oropharynx cancer with significant p16 expression showed an increased overall survival and elevated T- and B-lymphocyte infiltration, which suggests a prognostic relevance of immune cell infiltration.
DOI: 10.6084/m9.figshare.6171617.v1
title: Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab

description: <b>Background:</b> The introduction of immune check-point inhibition in non-small cell lung cancer (NSCLC) therapy represents improved prospects for the patients. The response rates to check-point inhibitors are approximately 20% in unselected NSCLC patients. Increasing levels of tumor PD-L1 expression are associated with higher response rates. However, patients with low PD-L1 levels may also have durable responses, and improved strategies for patient stratification are needed. <b>Material and methods:</b> In this study, we investigated circulating microRNAs aiming to identify circulating predictive biomarkers associated with increased overall survival after immune check-point treatment. Using next generation sequencing, we performed microRNA profiling in serum from NSCLC patients (<i>n</i> = 20) treated with nivolumab. Serum samples from 31 patients were used for validation using qPCR assays. Serum samples were collected prior to immune therapy initiation. <b>Results:</b> Based on multivariate regression analysis, we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival (OS) &gt; 6 months in discovery cohort (<i>p</i> = .0003). We further validated this in another similar set of samples (<i>n</i> = 31) and the model was significantly associated with overall survival (OS) &gt; 6 months (<i>p</i> = .001) with sensitivity and specificity of 71% and 90%, respectively. <b>Conclusions:</b> In this study of circulating microRNAs, we have identified a 7-miR signature associated with survival in nivolumab-treated NSCLC patients. This signature may lead to better treatment options for patients with NSCLC, but a validation in an independent cohort is needed to confirm the predicted potential.
DOI: 10.6084/m9.figshare.6293384.v1
title: DW-MRI and DCE-MRI are of complementary value in predicting pathologic response to neoadjuvant chemoradiotherapy for esophageal cancer

description: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2–3) (per) and after completion of nCRT, but prior to esophagectomy (post). Subsequently, histopathologic tumor regression grade (TRG) was assessed. Tumor apparent diffusion coefficient (ADC) and area-under-the-concentration time curve (AUC) were calculated for DW-MRI and DCE-MRI, respectively. The ability of these parameters to predict pathologic complete response (pCR, TRG1) or good response (GR, TRG ≤ 2) to nCRT was assessed. Furthermore the complementary value of DW-MRI and DCE-MRI was investigated. GR was found in 22 (49%) patients, of which 10 (22%) patients showed pCR. For DW-MRI, the 75th percentile (P75) ΔADC<sub>post-pre</sub> was most predictive for GR (c-index = 0.75). For DCE-MRI, P90 ΔAUC<sub>per-pre</sub> was most predictive for pCR (c-index = 0.79). Multivariable logistic regression analyses showed complementary value when combining DW-MRI and DCE-MRI for pCR prediction (c-index = 0.89). Both DW-MRI and DCE-MRI are promising in predicting response to nCRT in esophageal cancer. Combining both modalities provides complementary information, resulting in a higher predictive value.
DOI: 10.6084/m9.figshare.5891929
title: Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014

description: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014. All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence. About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980–1984 to 62.4% in 2010–2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival. This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.
DOI: 10.6084/m9.figshare.6189620.v2
title: Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)

description: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy<sup>®</sup>, proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. A multicenter (<i>n</i> = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy<sup>®</sup>, PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36.0/1.8 Gy). Different treatment plans were optimized based on the same planning target volume margin. All participating institutes returned their best treatment plan applicable in clinic. The modern radiotherapy techniques investigated resulted in superior conformity/homogeneity-indices (CI/HI), particularly in the spinal part of the target (CI: 3D-CRT:0.3 vs. modern:0.6; HI: 3D-CRT:0.2 vs. modern:0.1), and demonstrated a decreased dose to the thyroid, heart, esophagus and pancreas. Dose reductions of &gt;10.0 Gy were observed with PBS compared to modern photon techniques for parotid glands, thyroid and pancreas. Following this technique, a wide range in dosimetry among centers using the same technique was observed (e.g., thyroid mean dose: VMAT: 5.6–24.6 Gy; PBS: 0.3–10.1 Gy). The investigated modern radiotherapy techniques demonstrate superior dosimetric results compared to 3D-CRT. The lowest mean dose for organs at risk is obtained with proton therapy. However, for a large number of organs ranges in mean doses were wide and overlapping between techniques making it difficult to recommend one radiotherapy technique over another.
DOI: 10.6084/m9.figshare.6189620.v1
title: Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)<sup>*</sup>

description: <b>Purpose:</b> Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy<sup>®</sup>, proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. <b>Material and methods:</b> A multicenter (<i>n</i> = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy<sup>®</sup>, PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36.0/1.8 Gy). Different treatment plans were optimized based on the same planning target volume margin. All participating institutes returned their best treatment plan applicable in clinic. <b>Results:</b> The modern radiotherapy techniques investigated resulted in superior conformity/homogeneity-indices (CI/HI), particularly in the spinal part of the target (CI: 3D-CRT:0.3 vs. modern:0.6; HI: 3D-CRT:0.2 vs. modern:0.1), and demonstrated a decreased dose to the thyroid, heart, esophagus and pancreas. Dose reductions of &gt;10.0 Gy were observed with PBS compared to modern photon techniques for parotid glands, thyroid and pancreas. Following this technique, a wide range in dosimetry among centers using the same technique was observed (e.g., thyroid mean dose: VMAT: 5.6–24.6 Gy; PBS: 0.3–10.1 Gy). <b>Conclusions:</b> The investigated modern radiotherapy techniques demonstrate superior dosimetric results compared to 3D-CRT. The lowest mean dose for organs at risk is obtained with proton therapy. However, for a large number of organs ranges in mean doses were wide and overlapping between techniques making it difficult to recommend one radiotherapy technique over another.
DOI: 10.5281/zenodo.6427258
title: Stocks d' entreteniment durant la COVID-19

description: Evolució dels principals stocks d' entreteniment durant el lockdown de la COVID 19. En aquest cas el periode d' analisis va des de el març de 2020 fins al maig del 2021 que es quan es va acabar l' estat de emergencia. Concretament mostra informació sobre el preu d'obertura, tancament, màxim i mínim de la sessió, així com el volum, els dividends concedits als inversors i la presència de splits d'accions generats per dia.
DOI: 10.5281/zenodo.6427257
title: Stocks d' entreteniment durant la COVID-19

description: Evolució dels principals stocks d' entreteniment durant el lockdown de la COVID 19. En aquest cas el periode d' analisis va des de el març de 2020 fins al maig del 2021 que es quan es va acabar l' estat de emergencia. Concretament mostra informació sobre el preu d'obertura, tancament, màxim i mínim de la sessió, així com el volum, els dividends concedits als inversors i la presència de splits d'accions generats per dia.
DOI: 10.34740/kaggle/dsv/3432303
title: COVID Vaccination in World (updated daily)
DOI: 10.26180/18217145
title: Javier Gomez-Ortega thesis_Feb 2022

description: supplementary data for thesis
DOI: 10.26180/18217145.v1
title: Javier Gomez-Ortega thesis_Feb 2022

description: supplementary data for thesis
DOI: 10.6084/m9.figshare.19333646
title: Table

description: Tables for MOCCS paper
DOI: 10.6084/m9.figshare.19333646.v2
title: Table

description: Tables for MOCCS paper
DOI: 10.6084/m9.figshare.19333646.v1
title: Table

description: Tables for MOCCS paper
DOI: 10.6084/m9.figshare.14709409
title: The Plus in Credit-Plus-Technical Assistance: Evidence from a Rural Microcredit Programme in Bolivia

description: Microfinance institutions traditionally focus on the provision of credit and other financial services. In light of recent evidence on the scant transformative effects of ‘standard’ microcredit models, however, some lenders are increasing efforts to offer additional non-financial services – such as business trainings and technical assistance. While literature on the effects of business trainings is quite voluminous, far less attention has been paid to microcredit in combination with technical assistance, especially salient in rural contexts. This study investigates a programme launched by Sembrar Sartawi, a Bolivian MFI, which complemented dairy farming credit with the provision of agronomic and veterinarian expertise. We collect data of approximately 600 dairy farmers from the Bolivian plateau over two data-collection waves, and conduct a variety of cross-sectional and panel regression analyses. We find that technical assistance has positive, statistically significant, and economically salient impacts on monthly revenues and milk production. Our study strongly suggests that providing access to technical assistance can be a very effective ‘plus’ instrument for MFIs providing financial services to rural clients. We also point at the importance of conducting further research related to cost-effectiveness, to assess whether MFIs may expand technical assistance and at the same time achieve self-sustainability.
DOI: 10.6084/m9.figshare.14709409.v1
title: The Plus in Credit-Plus-Technical Assistance: Evidence from a Rural Microcredit Programme in Bolivia

description: Microfinance institutions traditionally focus on the provision of credit and other financial services. In light of recent evidence on the scant transformative effects of ‘standard’ microcredit models, however, some lenders are increasing efforts to offer additional non-financial services – such as business trainings and technical assistance. While literature on the effects of business trainings is quite voluminous, far less attention has been paid to microcredit in combination with technical assistance, especially salient in rural contexts. This study investigates a programme launched by Sembrar Sartawi, a Bolivian MFI, which complemented dairy farming credit with the provision of agronomic and veterinarian expertise. We collect data of approximately 600 dairy farmers from the Bolivian plateau over two data-collection waves, and conduct a variety of cross-sectional and panel regression analyses. We find that technical assistance has positive, statistically significant, and economically salient impacts on monthly revenues and milk production. Our study strongly suggests that providing access to technical assistance can be a very effective ‘plus’ instrument for MFIs providing financial services to rural clients. We also point at the importance of conducting further research related to cost-effectiveness, to assess whether MFIs may expand technical assistance and at the same time achieve self-sustainability.
DOI: 10.6084/m9.figshare.16552054
title: Elite Status, Market Linkages, and Contributions to Collective Goods: Evidence from a Survey and Public Goods Experiments

description: Cooperation is particularly important in the management of common resources where the user rights of individuals are collective. We used a one-shot public goods experiment to construct a measure of social capital, based on ‘multilateral’ cooperative behaviour, where each participant had free-riding incentives. This study was conducted in four rural villages of Odisha in India in the course of a project studying irrigation. Participants were male farmers from different social groups. Combining survey data with the artefactual field experiments, we examined how an individual’s willingness to contribute to the collective good was affected by social and economic characteristics, and political connections to the local administrative unit. The results suggest interesting differences in cooperation: in the less remote villages, farmers were less cooperative on average compared to farmers living in more remote villages. Furthermore, we found that wealthy and influential farmers invested less in the provision of a public good, reducing the likelihood of successful collective action. The findings are relevant both to the ‘collective action in the commons’ discourse and the literature on using experimental methods to deal with an individual’s true preferences for a public good.
DOI: 10.6084/m9.figshare.19469410
title: Ethnicity and Risk Sharing Network Formation: Evidence from Rural Vietnam

description: The ethnic divide remains a persistent challenge for Vietnam. This paper explores one mechanism that could drive ethnic inequalities by analysing risk-sharing networks in rural communes. After finding substantial differences in size and composition between ethnic minority and Kinh household networks, we explore homophily patterns in link formation as drivers of these differences. In particular, we disentangle baseline homophily stemming from the different local distributions of ethnic groups from inbreeding homophily resulting from mechanisms such as ethnic-based preferences and/or biased matching processes and its effects on network structure. We find that ethnic segregation in social networks (inbreeding homophily) leads to ethnic minorities having smaller, less diversified networks than the Kinh majority. We show that inbreeding homophily is more frequent in Kinh networks than in other groups; and seems to be driven in part by segmentation of social interactions within rural communes. This pattern means that compared to other groups, Kinh could be more efficiently insured against covariant risks as they can rely on larger and more diversified risk-sharing network in terms of member occupation and location. Under this view, inequalities among ethnic groups in Vietnam appear to be partially rooted in the cultural and social distances between them.