cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3465923.v1
title: Regioselective Mitsunobu Reaction of Partially Protected Uridine

description: Mitsunobu reaction of partially acylated uridine proceeds with high regioselectivity for intramolecular S<sub>N</sub>2 anhydro linkage closuring. Under the reaction conditions, an isomeric mixture of diacyl uridine derivatives with either free 2′- or 3′-hydroxyl group was transformed into a single cyclonucleosidic product, 2,2′-anhydro-3′,5′-di-O-acyluridine. This paper presents a possible mechanism of the reactions, the explanation of observed phenomenon based on semiempirical and density functional theory (DFT) calculations and possible utility of this synthetic pathway.
DOI: 10.6084/m9.figshare.3465866
title: Effects of visceral adipose tissue reduction on CVD risk factors independent of weight loss: The Look AHEAD study

description: <b>Objectives:</b> To determine if the reduction of visceral adipose tissue (VAT) volume by lifestyle intervention improved risk factors for cardiovascular disease (CVD) independent of weight loss amount. <b>Design:</b> Ancillary study of randomized-controlled trial. Setting: Data analysis using multivariable regression models. <b>Participants:</b> Participants of the Look AHEAD (Action for HEAlth in Diabetes) Fatty Liver Ancillary Study. <b>Main outcome measures:</b> Correlations between changes in VAT and in CVD risk factors, while adjusting for weight loss and treatment (intensive lifestyle intervention [ILI] vs. diabetes support and education [DSE]). <b>Results:</b> Of 100 participants analyzed, 52% were women, and 36% were black, with a mean age of 61.1 years. In the DSE group, mean weight and VAT changed by 0.1 % (<i>p</i>=0.90) and 4.3% (<i>p</i>=0.39), respectively. In the ILI group, mean weight and VAT decreased by 8.0% (<i>p</i>&lt;0.001) and 7.7% (<i>p</i>=0.01), respectively. Across both groups, mean weight decreased by 3.6% (<i>p</i>&lt;0.001), and mean VAT decreased by 1.2% (<i>p</i>=0.22); the decrease in VAT was correlated with the increase in HDL-cholesterol (HDL-C; R=−0.37; <i>p</i>=0.03). There were no correlations between changes in VAT and blood pressure, triglycerides, LDL-C, glucose, or HbA1c. After adjusting for age, race, gender, baseline metabolic values, fitness, and treatment group, changes in HDL-C were not associated with changes in VAT, while weight changes were independently associated with decrease in glucose, HbA1c, and increase in HDL-C. <b>Conclusions:</b> VAT reduction was not correlated with improvements of CVD risk factors in a sample of overweight and obese adults with type 2 diabetes after adjusting for weight loss.
DOI: 10.6084/m9.figshare.3465866.v1
title: Effects of visceral adipose tissue reduction on CVD risk factors independent of weight loss: The Look AHEAD study

description: <b>Objectives:</b> To determine if the reduction of visceral adipose tissue (VAT) volume by lifestyle intervention improved risk factors for cardiovascular disease (CVD) independent of weight loss amount. <b>Design:</b> Ancillary study of randomized-controlled trial. Setting: Data analysis using multivariable regression models. <b>Participants:</b> Participants of the Look AHEAD (Action for HEAlth in Diabetes) Fatty Liver Ancillary Study. <b>Main outcome measures:</b> Correlations between changes in VAT and in CVD risk factors, while adjusting for weight loss and treatment (intensive lifestyle intervention [ILI] vs. diabetes support and education [DSE]). <b>Results:</b> Of 100 participants analyzed, 52% were women, and 36% were black, with a mean age of 61.1 years. In the DSE group, mean weight and VAT changed by 0.1 % (<i>p</i>=0.90) and 4.3% (<i>p</i>=0.39), respectively. In the ILI group, mean weight and VAT decreased by 8.0% (<i>p</i>&lt;0.001) and 7.7% (<i>p</i>=0.01), respectively. Across both groups, mean weight decreased by 3.6% (<i>p</i>&lt;0.001), and mean VAT decreased by 1.2% (<i>p</i>=0.22); the decrease in VAT was correlated with the increase in HDL-cholesterol (HDL-C; R=−0.37; <i>p</i>=0.03). There were no correlations between changes in VAT and blood pressure, triglycerides, LDL-C, glucose, or HbA1c. After adjusting for age, race, gender, baseline metabolic values, fitness, and treatment group, changes in HDL-C were not associated with changes in VAT, while weight changes were independently associated with decrease in glucose, HbA1c, and increase in HDL-C. <b>Conclusions:</b> VAT reduction was not correlated with improvements of CVD risk factors in a sample of overweight and obese adults with type 2 diabetes after adjusting for weight loss.
DOI: 10.6084/m9.figshare.3465806
title: Tripaddled Anterolateral Thigh Chimeric Flap for Extensive Full-thickness Cheek Reconstruction after Radical Resection of Advanced Buccal Cancer

description: Tripaddled Anterolateral Thigh Chimeric Flap for Extensive Full-thickness Cheek Reconstruction after Radical Resection of Advanced Buccal Cancer
DOI: 10.6084/m9.figshare.3465806.v1
title: Tripaddled Anterolateral Thigh Chimeric Flap for Extensive Full-thickness Cheek Reconstruction after Radical Resection of Advanced Buccal Cancer

description: Tripaddled Anterolateral Thigh Chimeric Flap for Extensive Full-thickness Cheek Reconstruction after Radical Resection of Advanced Buccal Cancer
DOI: 10.17028/rd.lboro.3465764
title: Shear-acoustic multiple scattering silica in water data JASA 2017

description: These files are Excel spreadsheets holding the data used to produce the figures in the paper below. The calculations were carried out using Matlab, and are for suspensions of silica particles (of various sizes) in water."Multiple scattering in random dispersions of spherical scatterers: effects of shear-acoustic interactions." submitted to Journal of the Acoustical Society of America, June 2016. Accepted December 2016.
DOI: 10.17028/rd.lboro.3465764.v1
title: Shear-acoustic multiple scattering silica in water data JASA 2017

description: These files are Excel spreadsheets holding the data used to produce the figures in the paper below. The calculations were carried out using Matlab, and are for suspensions of silica particles (of various sizes) in water."Multiple scattering in random dispersions of spherical scatterers: effects of shear-acoustic interactions." submitted to Journal of the Acoustical Society of America, June 2016. Accepted December 2016.
DOI: 10.6084/m9.figshare.3465686
title: Periodic Table of Digital Research Resources

description: This is figure is lays out different digital research tools and resources. It is meant for people looking to discover new tools for research, publication, and dissemination.<br>This figure will be annotated for context, so that researchers can more easily understand what each tool does, how to use it, and its level of difficulty.<br><br>
DOI: 10.6084/m9.figshare.3465677
title: DTI responses UoM&UI.xlsx

description: DTI data from the UI and UoM<br>
DOI: 10.6084/m9.figshare.3465677.v1
title: DTI responses UoM&UI.xlsx

description: DTI data from the UI and UoM<br>
DOI: 10.6084/m9.figshare.3465671
title: On new or poorly known Australian Filistatidae spiders (Araneae: Araneomorphae), including a study on the fine morphology of <i>Wandella</i>

description: I present an update on the taxonomy of the filistatid genera <i>Wandella</i> Gray and <i>Yardiella</i> Gray, both endemic to Australia. Two new species are described: <i>Wandella grayi</i> sp. nov., known from Queensland, and <i>Wandella infernalis</i> sp. nov., known from a single cave in Western Australia. The male of <i>Wandella australiensis</i> (L. Koch) and the females of <i>Wandella stuartensis</i> Gray and <i>Wandella waldockae</i> Gray are described and illustrated for the first time. New records are given for these and other species of Australian filistatids, including the first epigeal records of <i>Yardiella humphreysi</i> Gray, a species so far known only from caves. Updated distribution maps are presented. Additionally, I present novel morphological data for <i>Wandella</i> using light and scanning electron microscopy. The cephalothorax, spinning organs, genitalia and appendages of some species are illustrated in detail. I report the presence of a putative claw extensor muscle in the male palpal cymbium, and describe interesting modifications in the clypeal region of adult males. The phylogenetic significance of these characters is briefly discussed.
DOI: 10.6084/m9.figshare.3465671.v1
title: On new or poorly known Australian Filistatidae spiders (Araneae: Araneomorphae), including a study on the fine morphology of <i>Wandella</i>

description: I present an update on the taxonomy of the filistatid genera <i>Wandella</i> Gray and <i>Yardiella</i> Gray, both endemic to Australia. Two new species are described: <i>Wandella grayi</i> sp. nov., known from Queensland, and <i>Wandella infernalis</i> sp. nov., known from a single cave in Western Australia. The male of <i>Wandella australiensis</i> (L. Koch) and the females of <i>Wandella stuartensis</i> Gray and <i>Wandella waldockae</i> Gray are described and illustrated for the first time. New records are given for these and other species of Australian filistatids, including the first epigeal records of <i>Yardiella humphreysi</i> Gray, a species so far known only from caves. Updated distribution maps are presented. Additionally, I present novel morphological data for <i>Wandella</i> using light and scanning electron microscopy. The cephalothorax, spinning organs, genitalia and appendages of some species are illustrated in detail. I report the presence of a putative claw extensor muscle in the male palpal cymbium, and describe interesting modifications in the clypeal region of adult males. The phylogenetic significance of these characters is briefly discussed.
DOI: 10.6084/m9.figshare.3465629
title: Viability of pegIFNα-RBV for CHC in the direct acting antiviral era: a practical algorithm between efficacy and cost containment

description: The classical pegylated interferon α (peg-IFNα) and ribavirin (RBV) treatment of chronic hepatitis C (CHC) is progressively being replaced by new direct acting antivirals, whose costs remain a major barrier to widespread use. Using baseline data and viral kinetics, we developed a predictive algorithm to allocate to DAA patients who are not going to respond to peg-IFNα/RBV. This prospective study evaluated 205 CHC patients treated with peg-IFNα/RBV. HCVRNA kinetics during the initial 3 days of therapy and baseline variables including age, genotype, fibrosis and ALTs were used to construct a prediction rule in terms of sustained virological response (SVR). One hundred and twenty-one patients achieved an SVR (59%). Variables independently associated with SVR were HCVRNA, ALT, glycaemia, viral genotype, and fibrosis. The decline of viremia from baseline to 48/72 h was significantly different in SVR compared to non-SVR patients (2.2 vs. 0.65 log10 IU/mL; <i>p</i> 1.2 logs had a positive predictive value of 92%. A combination of HCVRNA kinetics and a score based on pre-treatment parameters was highly accurate in predicting SVR in most patients. Outcome of peg-IFNα/RBV treatment may be predicted combining evaluation of baseline variables and HCVRNA kinetics. This allows to individualize treatment, reserving newer and more expensive DAAs to CHC patients who are in most need of them.
DOI: 10.6084/m9.figshare.3465629.v1
title: Viability of pegIFNα-RBV for CHC in the direct acting antiviral era: a practical algorithm between efficacy and cost containment

description: The classical pegylated interferon α (peg-IFNα) and ribavirin (RBV) treatment of chronic hepatitis C (CHC) is progressively being replaced by new direct acting antivirals, whose costs remain a major barrier to widespread use. Using baseline data and viral kinetics, we developed a predictive algorithm to allocate to DAA patients who are not going to respond to peg-IFNα/RBV. This prospective study evaluated 205 CHC patients treated with peg-IFNα/RBV. HCVRNA kinetics during the initial 3 days of therapy and baseline variables including age, genotype, fibrosis and ALTs were used to construct a prediction rule in terms of sustained virological response (SVR). One hundred and twenty-one patients achieved an SVR (59%). Variables independently associated with SVR were HCVRNA, ALT, glycaemia, viral genotype, and fibrosis. The decline of viremia from baseline to 48/72 h was significantly different in SVR compared to non-SVR patients (2.2 vs. 0.65 log10 IU/mL; <i>p</i> 1.2 logs had a positive predictive value of 92%. A combination of HCVRNA kinetics and a score based on pre-treatment parameters was highly accurate in predicting SVR in most patients. Outcome of peg-IFNα/RBV treatment may be predicted combining evaluation of baseline variables and HCVRNA kinetics. This allows to individualize treatment, reserving newer and more expensive DAAs to CHC patients who are in most need of them.
DOI: 10.6084/m9.figshare.3465530
title: Supplementary Material for: A Comparison between Two Dilute Citrate Solutions (15 vs. 18 mmol/l) in Continuous Renal Replacement Therapy: The Base Excess and Renal Substitution Solution Study

description: <b><i>Background/Aims:</i></b> The study aimed to compare the changes in biochemistry occurring in patients undergoing continuous renal replacement therapy (CRRT) using 2 trisodium citrate solutions, Baxter hemofiltration fluid containing 18 mmol/l (C18) and Baxter NamSol, a custom manufactured solution containing 15 mmol/l (C15), both delivered as regional citrate anticoagulation (RCA) predilution fluids for hemofiltration. <b><i>Methods:</i></b> This is a prospective randomized control trial conducted in a major regional adult intensive care unit. Patients were randomized to 1 of 2 RCA fluids. Progress was monitored using a standard daily panel of acid-base and biochemical tests. <b><i>Results:</i></b> Forty-eight patients, 23 C18 and 25 C15, were recruited. In both groups, acidosis resolved within 36 h of institution of CRRT. By day 3, there were significant differences in serum [Na<sup>+</sup>], standard base excess and serum bicarbonate concentration, all being higher in the C18 group (p &lt; 0.01). By day 5, the PaCO<sub>2</sub> had also risen in the C18 group (p = 0.03). <b><i>Conclusions:</i></b> The C15 solution provided equivalent filter life to the C18 solution but without significant hypernatremia and metabolic alkalosis.
DOI: 10.6084/m9.figshare.3465530.v1
title: Supplementary Material for: A Comparison between Two Dilute Citrate Solutions (15 vs. 18 mmol/l) in Continuous Renal Replacement Therapy: The Base Excess and Renal Substitution Solution Study

description: <b><i>Background/Aims:</i></b> The study aimed to compare the changes in biochemistry occurring in patients undergoing continuous renal replacement therapy (CRRT) using 2 trisodium citrate solutions, Baxter hemofiltration fluid containing 18 mmol/l (C18) and Baxter NamSol, a custom manufactured solution containing 15 mmol/l (C15), both delivered as regional citrate anticoagulation (RCA) predilution fluids for hemofiltration. <b><i>Methods:</i></b> This is a prospective randomized control trial conducted in a major regional adult intensive care unit. Patients were randomized to 1 of 2 RCA fluids. Progress was monitored using a standard daily panel of acid-base and biochemical tests. <b><i>Results:</i></b> Forty-eight patients, 23 C18 and 25 C15, were recruited. In both groups, acidosis resolved within 36 h of institution of CRRT. By day 3, there were significant differences in serum [Na<sup>+</sup>], standard base excess and serum bicarbonate concentration, all being higher in the C18 group (p &lt; 0.01). By day 5, the PaCO<sub>2</sub> had also risen in the C18 group (p = 0.03). <b><i>Conclusions:</i></b> The C15 solution provided equivalent filter life to the C18 solution but without significant hypernatremia and metabolic alkalosis.
DOI: 10.6084/m9.figshare.3465473
title: Supplementary Material for: Induction of Myeloid-Derived Suppressor Cells in Cryopyrin-Associated Periodic Syndromes

description: Cryopyrin-associated periodic syndromes (CAPS) are caused by mutations in the <i>NLRP3</i> gene leading to overproduction of IL-1β and other NLRP3 inflammasome products. Myeloid-derived suppressor cells (MDSCs) represent a novel innate immune cell subset capable of suppressing T-cell responses. As inflammasome products were previously found to induce MDSCs, we hypothesized that NLRP3 inflammasome-dependent factors induce the generation of MDSCs in CAPS. We studied neutrophilic MDSCs, their clinical relevance, and MDSC-inducing factors in a unique cohort of CAPS patients under anti-IL-1 therapy. Despite anti-IL-1 therapy and low clinical disease activity, CAPS patients showed significantly elevated MDSCs compared to healthy controls. MDSCs were functionally competent, as they suppressed polyclonal T-cell proliferation, as well as Th1 and Th17 responses. In addition, MDSCs decreased monocytic IL-1β secretion. Multiplex assays revealed a distinct pattern of MDSC-inducing cytokines, chemokines, and growth factors. Experimental analyses demonstrated that IL-1 cytokine family members and autoinflammation-associated alarmins differentially induced human MDSCs. Increased MDSCs might represent a novel autologous anti-inflammatory mechanism in autoinflammatory conditions and may serve as a future therapeutic target.
DOI: 10.6084/m9.figshare.3465473.v1
title: Supplementary Material for: Induction of Myeloid-Derived Suppressor Cells in Cryopyrin-Associated Periodic Syndromes

description: Cryopyrin-associated periodic syndromes (CAPS) are caused by mutations in the <i>NLRP3</i> gene leading to overproduction of IL-1β and other NLRP3 inflammasome products. Myeloid-derived suppressor cells (MDSCs) represent a novel innate immune cell subset capable of suppressing T-cell responses. As inflammasome products were previously found to induce MDSCs, we hypothesized that NLRP3 inflammasome-dependent factors induce the generation of MDSCs in CAPS. We studied neutrophilic MDSCs, their clinical relevance, and MDSC-inducing factors in a unique cohort of CAPS patients under anti-IL-1 therapy. Despite anti-IL-1 therapy and low clinical disease activity, CAPS patients showed significantly elevated MDSCs compared to healthy controls. MDSCs were functionally competent, as they suppressed polyclonal T-cell proliferation, as well as Th1 and Th17 responses. In addition, MDSCs decreased monocytic IL-1β secretion. Multiplex assays revealed a distinct pattern of MDSC-inducing cytokines, chemokines, and growth factors. Experimental analyses demonstrated that IL-1 cytokine family members and autoinflammation-associated alarmins differentially induced human MDSCs. Increased MDSCs might represent a novel autologous anti-inflammatory mechanism in autoinflammatory conditions and may serve as a future therapeutic target.
DOI: 10.6084/m9.figshare.3465440
title: Analysis of xenotransplanted mice testes one-month after transplantation using a buffalo gonocytes spermatogonia-specific marker, Dolichos biflorus agglutinin (DBA)..png

description: (A) DBA stained gonocytes/spermatogonia (arrows) that colonized the basal membrane of the recipient testis. Note that a few uncolonized DBA-positive gonocytes/spermatogonia are seen in lumen of seminiferous tubules (arrowheads). (B) No DBA-positive cells are visible in the contralateral testis section. Scale bar = 50 µm.<br>
DOI: 10.6084/m9.figshare.3465440.v1
title: Analysis of xenotransplanted mice testes one-month after transplantation using a buffalo gonocytes spermatogonia-specific marker, Dolichos biflorus agglutinin (DBA)..png

description: (A) DBA stained gonocytes/spermatogonia (arrows) that colonized the basal membrane of the recipient testis. Note that a few uncolonized DBA-positive gonocytes/spermatogonia are seen in lumen of seminiferous tubules (arrowheads). (B) No DBA-positive cells are visible in the contralateral testis section. Scale bar = 50 µm.<br>
DOI: 10.6084/m9.figshare.3465437
title: Fluorescence-double staining of testicular cells.png

description: Cells isolated from a 5-month-old buffalo testis stained with POU5F1 (A), and DBA (B). Most DBA binding cells are positive for POU5F1 expression (arrows). POU5F1 expression is occasionally weak or absent in DBA-positive cells (arrowheads). (C) Cells stained with DAPI. Scale bar = 50 µm.<br>
DOI: 10.6084/m9.figshare.3465437.v1
title: Fluorescence-double staining of testicular cells.png

description: Cells isolated from a 5-month-old buffalo testis stained with POU5F1 (A), and DBA (B). Most DBA binding cells are positive for POU5F1 expression (arrows). POU5F1 expression is occasionally weak or absent in DBA-positive cells (arrowheads). (C) Cells stained with DAPI. Scale bar = 50 µm.<br>
DOI: 10.6084/m9.figshare.3465425
title: Western blot aAnalysis to demonstrate that anti-POU5F1 antibody identifies proteins of defined molecular weight in buffalo testes.png

description: Protein lysates from prepubertal (4- to 6- month old; lane 1) and from adult (2- to 3- year old; lane 2) buffalo testes shows that POU5F1 protein exists in two isoforms; large (∼47 kDa) and small (∼21 kDa). BETA-ACTIN was used for normalizing protein samples.<br>
DOI: 10.6084/m9.figshare.3465425.v1
title: Western blot aAnalysis to demonstrate that anti-POU5F1 antibody identifies proteins of defined molecular weight in buffalo testes.png

description: Protein lysates from prepubertal (4- to 6- month old; lane 1) and from adult (2- to 3- year old; lane 2) buffalo testes shows that POU5F1 protein exists in two isoforms; large (∼47 kDa) and small (∼21 kDa). BETA-ACTIN was used for normalizing protein samples.<br>
DOI: 10.6084/m9.figshare.3465413
title: Resultados Priscila (evolução ponderal, peso neonatal, volume renal, massa cardiaca e renal, número de glomérulos .pzf

description: The shared results are all given as GraphPad Prism files.
DOI: 10.6084/m9.figshare.3465413.v1
title: Resultados Priscila (evolução ponderal, peso neonatal, volume renal, massa cardiaca e renal, número de glomérulos .pzf

description: The shared results are all given as GraphPad Prism files.
DOI: 10.6084/m9.figshare.3465407.v2
title: PeerJ2016_Scarsoglio

description: Computational fluid dynamics modelling of left valvular heart diseases during atrial fibrillation, Scarsoglio, S. and Saglietto, A. and Gaita, F. and Ridolfi, L. and Anselmino, M., PeerJ 2016<br>
DOI: 10.6084/m9.figshare.3465386
title: CCR2 CC5 and SDF1 antagonist.pdf

description: CCR2 CC5 and SDF1 antagonist<br>
DOI: 10.6084/m9.figshare.3465386.v1
title: CCR2 CC5 and SDF1 antagonist.pdf

description: CCR2 CC5 and SDF1 antagonist<br>
DOI: 10.6084/m9.figshare.3465383
title: Natural ligand mediated inhibition of HIV1 Ranjeet Singh Mahla.gif

description: Natural ligand mediated inhibition of HIV1 <br>
DOI: 10.6084/m9.figshare.3465383.v1
title: Natural ligand mediated inhibition of HIV1 Ranjeet Singh Mahla.gif

description: Natural ligand mediated inhibition of HIV1 <br>
DOI: 10.6084/m9.figshare.3465371
title: Holmes metagenome assembly

description: R formated metagenome dataset.
DOI: 10.6084/m9.figshare.3465371.v1
title: Holmes metagenome assembly

description: R formated metagenome dataset.
DOI: 10.6084/m9.figshare.3465362.v1
title: Data extracted from SDSS, used in Stensbo-Smidt et al. (2016)

description: Magnitudes, photo-z's and sSFRs extracted from SDSS.
DOI: 10.6084/m9.figshare.3465359
title: Herrero-Sánchez Data

description: Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graftversus-host disease development.
DOI: 10.6084/m9.figshare.3465359.v1
title: Herrero-Sánchez Data

description: Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graftversus-host disease development.