cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14322260
title: Glycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by electrospray ionization mass spectrometry

description: ABSTRACT Objective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression. Methods Tissue samples from neoplastic and non-neoplastic colorectal tissues were obtained from 64 operated patients who had colorectal carcinoma with no distant metastases. Expressions of heparan sulphate, chondroitin sulphate, dermatan sulphate and their fragments were analyzed by electrospray ionization mass spectrometry, with the technique for extraction and quantification of glycosaminoglycans after proteolysis and electrophoresis. The statistical analysis included mean, standard deviation, and Student’st test. Results The glycosaminoglycans extracted from colorectal tissue showed three electrophoretic bands in agarose gel. Electrospray ionization mass spectrometry showed characteristic disaccharide fragments from glycosaminoglycans, indicating their structural characterization in the tissues analyzed. Some peaks in the electrospray ionization mass spectrometry were not characterized as fragments of sugars, indicating the presence of fragments of the protein structure of proteoglycans generated during the glycosaminoglycan purification. The average amount of chondroitin and dermatan increased in the neoplastic tissue compared to normal tissue (p=0.01). On the other hand, the average amount of heparan decreased in the neoplastic tissue compared to normal tissue (p= 0.03). Conclusion The method allowed the determination of the glycosaminoglycans structural profile in colorectal tissue from neoplastic and non-neoplastic colorectal tissue. Neoplastic tissues showed greater amounts of chondroitin sulphate and dermatan sulphate compared to non-neoplastic tissues, while heparan sulphate was decreased in neoplastic tissues.
DOI: 10.6084/m9.figshare.14322260.v1
title: Glycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by electrospray ionization mass spectrometry

description: ABSTRACT Objective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression. Methods Tissue samples from neoplastic and non-neoplastic colorectal tissues were obtained from 64 operated patients who had colorectal carcinoma with no distant metastases. Expressions of heparan sulphate, chondroitin sulphate, dermatan sulphate and their fragments were analyzed by electrospray ionization mass spectrometry, with the technique for extraction and quantification of glycosaminoglycans after proteolysis and electrophoresis. The statistical analysis included mean, standard deviation, and Student’st test. Results The glycosaminoglycans extracted from colorectal tissue showed three electrophoretic bands in agarose gel. Electrospray ionization mass spectrometry showed characteristic disaccharide fragments from glycosaminoglycans, indicating their structural characterization in the tissues analyzed. Some peaks in the electrospray ionization mass spectrometry were not characterized as fragments of sugars, indicating the presence of fragments of the protein structure of proteoglycans generated during the glycosaminoglycan purification. The average amount of chondroitin and dermatan increased in the neoplastic tissue compared to normal tissue (p=0.01). On the other hand, the average amount of heparan decreased in the neoplastic tissue compared to normal tissue (p= 0.03). Conclusion The method allowed the determination of the glycosaminoglycans structural profile in colorectal tissue from neoplastic and non-neoplastic colorectal tissue. Neoplastic tissues showed greater amounts of chondroitin sulphate and dermatan sulphate compared to non-neoplastic tissues, while heparan sulphate was decreased in neoplastic tissues.
DOI: 10.6084/m9.figshare.14321890.v1
title: Adaptation and analysis of a didactic laminator for non-ferrous metals

description: ABSTRACT Lamination is a plastic deformation forming process widely used in the industry for the processing of semi-finished metal alloys, as it not only gives the desired commercial shape to the product, but also provides increased mechanical properties in a continuous and high productivity process. In this way, it is important that the engineering academic understand how the equipment used in the lamination works and what are the variables that influence this process. In this context, and thinking that skills obtained through experiments that relate theory to practice are fundamental for the formation of an engineer, the purpose of this work was to design and adapt a didactic laminator of the duo type, for nonferrous metals that, employee during the graduation, promote greater proximity of engineering students with this industrial process. The adaptation of this device was based on an existing manual jewelry mill, which was coupled to an electric motor that promoted the power needed for the process. The result of this work was the adaptation of a rolling mill that met the lamination expectations, being available for the elaboration of activities that propel the academic understanding on the subject. In relation to the metals that were rolled, several characteristics of the cold rolling process and its products described in the literature and in the mechanical transformation industry were observed during the execution of the tests of operation and of the tests, thus validating the adaptation of the equipment and the achievement of its main objective.
DOI: 10.6084/m9.figshare.14322261
title: An update of neurological manifestations of vasculitides and connective tissue diseases: a literature review

description: Vasculitides comprise a heterogeneous group of autoimmune disorders, occurring as primary or secondary to a broad variety of systemic infectious, malignant or connective tissue diseases. The latter occur more often but their pathogenic mechanisms have not been fully established. Frequent and varied central and peripheral nervous system complications occur in vasculitides and connective tissue diseases. In many cases, the neurological disorders have an atypical clinical course or even an early onset, and the healthcare professionals should be aware of them. The purpose of this brief review was to give an update of the main neurological disorders of common vasculitis and connective tissue diseases, aiming at accurate diagnosis and management, with an emphasis on pathophysiologic mechanisms.
DOI: 10.6084/m9.figshare.14322261.v1
title: An update of neurological manifestations of vasculitides and connective tissue diseases: a literature review

description: Vasculitides comprise a heterogeneous group of autoimmune disorders, occurring as primary or secondary to a broad variety of systemic infectious, malignant or connective tissue diseases. The latter occur more often but their pathogenic mechanisms have not been fully established. Frequent and varied central and peripheral nervous system complications occur in vasculitides and connective tissue diseases. In many cases, the neurological disorders have an atypical clinical course or even an early onset, and the healthcare professionals should be aware of them. The purpose of this brief review was to give an update of the main neurological disorders of common vasculitis and connective tissue diseases, aiming at accurate diagnosis and management, with an emphasis on pathophysiologic mechanisms.
DOI: 10.6084/m9.figshare.14321809.v1
title: Analysis of epoxy based paint efficiency in expanded clay lightweight concrete protection of sulfuric acid attack

description: ABSTRACT The purpose of this study is to analyze the efficiency of epoxydic base paint used as a protective coating on expanded clay lightweight concrete under sulfuric acid (H2SO4) attack. External attacks can promote expansions and accelerated degradation, reducing the concrete durability. Developed protections, such as paints have an important performance result, because they have good adhesion to the concrete surface, weathering and photodegradation resistant, besides provide a good chemical stability. The performance of epoxydic paint was assessed through visual inspection, compressive strength test, water absorption and mass losses before and after chemical attack. The visual inspection demonstrated that the epoxy-coated lightweight concrete specimens had a clear reduction in the loss of cohesion of the paste caused by the attack. The teste results of regarding water absorption, mass loss and mechanical strength showed the good performance of the epoxydic base paint, preventing the penetration of the aggressive agent on protected concretes. This research shows that epoxydic protection reduces the impact of external acid attacks on concrete and can improve the durability of expanded clay lightweight concrete structures.
DOI: 10.6084/m9.figshare.14322263.v1
title: Differential diagnosis of dental fluorosis made by undergraduate dental students

description: ABSTRACT Objective To check knowledge of undergraduate dental students to make diagnosis of dental fluorosis with varying degrees of severity and choose its appropriate treatment. Methods Data were collected using a semi-structured questionnaire addressing knowledge of undergraduates based on ten images of mouths presenting enamel changes. Results Only three images were correctly diagnosed by most undergraduates; the major difficulty was in establishing dental fluorosis severity degree. Conclusion Despite much information about fluorosis conveyed during the Dentistry training, as defined in the course syllabus, a significant part of the students was not able to differentiate it from other lesions; they did not demonstrate expertise as to defining severity of fluorosis and indications for treatment, and could not make the correct diagnosis of enamel surface changes.
DOI: 10.6084/m9.figshare.14322263
title: Differential diagnosis of dental fluorosis made by undergraduate dental students

description: ABSTRACT Objective To check knowledge of undergraduate dental students to make diagnosis of dental fluorosis with varying degrees of severity and choose its appropriate treatment. Methods Data were collected using a semi-structured questionnaire addressing knowledge of undergraduates based on ten images of mouths presenting enamel changes. Results Only three images were correctly diagnosed by most undergraduates; the major difficulty was in establishing dental fluorosis severity degree. Conclusion Despite much information about fluorosis conveyed during the Dentistry training, as defined in the course syllabus, a significant part of the students was not able to differentiate it from other lesions; they did not demonstrate expertise as to defining severity of fluorosis and indications for treatment, and could not make the correct diagnosis of enamel surface changes.
DOI: 10.6084/m9.figshare.14321785.v1
title: Polyester/paper composites: study of manufacturing techniques for product development

description: ABSTRACT Composite materials using vegetal fibers and industrial waste are being applied in different areas and structures, requiring, more and more, researches that highlight their characteristics. In this context, the study of manufacturing techniques becomes increasingly necessary in order to use the appropriate tools and obtain the best conditions of the materials. Thus, this article demonstrates the behavior of the materials, which used the polyester resin with ground paper residue to generate the two composites studied in this paper, Polyester/smaller paper (PO/ PME) and Polyester/large paper (PO/PMA). These two materials were molded by hot compression and subjected to manufacturing processes. Joinery equipment were chosen for the experimentation of cutting, drilling, screw insertion and sanding to analyze the performance of these composite materials. As a general result, it can be observed that the composites maintained their physical integrity, because the particles of the load remained well anchored in the matrix in the two composite materials tested, giving the finish an aspect without damages, cracks or imperfections after the operations. Therefore, it is concluded that the materials created can be submitted to the manufacturing techniques evaluated in this article, reinforcing previous studies that suggest its use in the development of products such as furniture, table tops, decorative objects and others. Thus, this study contributes to Designer has knowledge of the potential of the material and make the best use of it.
DOI: 10.6084/m9.figshare.14321772.v1
title: Evaluation of thermochemical and physicomechanical properties of three fast growing forest species

description: ABSTRACT The woods have distinct technological properties, as they are organic and heterogeneous material, requiring an assessment for proper use. Therefore, the objective of this work was the evaluation of technological properties, which are: basic density, apparent density at 12%, equilibrium moisture content, static flexion (MOE and MOR), parallel compression of the fibers (Fc and Ec), colorimetric analysis, thermogravimetry (TGA and DTG) and Fourier transform infrared spectroscopy (FT-IR), of the species of Corymbia maculata, Eucalyptus grandis, Pinus elliottii. The technological properties were determined as described in the ASTM D 2395-17 (2017) and ASTM D 143-94 (2014) standards. Regarding the physical-mechanical properties, the species showed significant differences based on statistical analysis, highlighting the species of Corymbia maculata. Regarding the colorimetric analysis, it was found that the species Corymbia maculata has a reddish-brown color, the Pinus elliottii species loves it with a light shade, while the Eucalyptus grandis reddish with a light shade. For FT-IR, similar peaks were found between species, but with different intensities, these being related to the molecular vibrations characteristic of the organic components of wood. Through thermogravimetric analysis, it can be seen that the species of Pinus elliottii and Corymbia maculata, presented greater thermal stability when compared to Eucalyptus grandis, having a lower percentage of mass loss and a delay in temperature in relation to the maximum peak of degradation ( DTG), close to 400 ° C, and these properties were analyzed with ANOVA tests with 5% significance. Thus, there is a heterogeneity among the species evaluated in this study, both from a physical, mechanical, thermal and chemical point of view, making it necessary to characterize these properties for the correct use of these materials.
DOI: 10.6084/m9.figshare.14322267
title: Male urethral sarcoma: a case report and literature review

description: Urethral tumors are rare and aggressive. They usually affect men (2:1) and occur more commonly in white (85% of cases). Soft tissue sarcomas are a heterogeneous group of tumors that arise from embryonic mesoderm. It represents 1% of all cases of urinary tract malignancies and rarely primary affect the ureter. We report a case of male urethral sarcoma. To date, only two similar cases have been published in literature.
DOI: 10.6084/m9.figshare.14322267.v1
title: Male urethral sarcoma: a case report and literature review

description: Urethral tumors are rare and aggressive. They usually affect men (2:1) and occur more commonly in white (85% of cases). Soft tissue sarcomas are a heterogeneous group of tumors that arise from embryonic mesoderm. It represents 1% of all cases of urinary tract malignancies and rarely primary affect the ureter. We report a case of male urethral sarcoma. To date, only two similar cases have been published in literature.
DOI: 10.6084/m9.figshare.14321641.v1
title: Residual stresses induced by milling operations of ABNT 4340 steel under variation of cutting speed, edge angle and heat treatment

description: ABSTRACT Among the various manufacturing processes, it is worth mentioning the machining. Among its operations is milling, which confers characteristics to the surface generated that influence the performance of the component or workpiece. One of these characteristics is the process-induced residual stress. Depending on its character, trative or compressive, intensity and depth affected, it can be beneficial or deleterious. This work investigated the effect of the parameters, cutting speed, edge angle and material condition, ABNT 4340 steel, obtained by annealing and normalizing heat treatments on residual stress induced on the surface. For this, a 2x3x2 factorial design with three replicates was performed. The residual stresses were measured by the hole drilling method. The results obtained were organized and analyzed on the qualitative aspects, profile along the depth, and quantitative. The results indicated that the increase of cutting speed caused the residual stress induced on the surface to be compressive or less tractive. The variation of the edge angle exerted a discrete effect on the residual stress. The milled material in the normalized condition showed compressive residual stresses, on the other hand in the annealed condition trative one. In order to evaluate the quantitative aspect, a variance analysis was performed for the residual stress induced in the depth of 17µm beneath surface. The results showed that the data follow a normal distribution and that the cutting speed and heat treatment factors were found to be significant at the 95% confidence level both in isolation and in the second and third order interactions
DOI: 10.6084/m9.figshare.14322269
title: Thoracolumbar Chance fracture during a professional female soccer game: case report

description: ABSTRACT We report a rare case of an unstable flexion-distraction spine fracture with ligament involvement that occurred during a professional female soccer game. There were no neurological déficit. The patient had a painful midline gap which suggested ligamentar injury that was not immediately recognized. Despite that, proper immobilization and referral to hospital for further evaluation avoided additional spinal cord damage. The patient underwent a monosegmental posterior instrumentation spine fusion and after 6 months returned to professional soccer activities. This paper alerts to the possibility of occurrence of severe and unstable spine injuries during soccer practice and the importance of an adequate initial care at the game field in order to avoid iatrogenic neurological injuries.
DOI: 10.6084/m9.figshare.14322269.v1
title: Thoracolumbar Chance fracture during a professional female soccer game: case report

description: ABSTRACT We report a rare case of an unstable flexion-distraction spine fracture with ligament involvement that occurred during a professional female soccer game. There were no neurological déficit. The patient had a painful midline gap which suggested ligamentar injury that was not immediately recognized. Despite that, proper immobilization and referral to hospital for further evaluation avoided additional spinal cord damage. The patient underwent a monosegmental posterior instrumentation spine fusion and after 6 months returned to professional soccer activities. This paper alerts to the possibility of occurrence of severe and unstable spine injuries during soccer practice and the importance of an adequate initial care at the game field in order to avoid iatrogenic neurological injuries.
DOI: 10.6084/m9.figshare.14321592.v1
title: Similar and dissimilar welding effect on the mechanical properties of 5383 H34, 5754 H34 and 6005 T6 aluminum alloys

description: ABSTRACT Aluminum alloys are not covered by their specific weight. Each class of aluminum alloy presents a set of properties that are favorable to a given function in the same product, just as the alloys may be present in the same vehicle. However, it is necessary to know the changes in the mechanical properties that occur with the union process of these aluminum alloys. The objective of this study was to evaluate the mechanical and morphological properties of alloys 5383 H34, 5754 H34 and 6005 T6 similarly welded and dissimilar by the MIG process. Six combinations of these alloys were characterized by mechanical tensile, folding and Vickers micro-hardness tests, as well as scanning electron microscopy (SEM) and optical microscopy (OM). Among the results obtained, a decrease in tensile strength was observed for all welded alloys. In addition, the microhardness was affected in the melt line, in the weld bead and in the HAZ (heat affected zone). The main causes of the reduction of the mechanical resistance of the welded alloys were the grain growth and the precipitate dissolution. The data obtained in this study contribute in a very positive way to the development and dimensioning of new projects and technologies involving aluminum alloys.
DOI: 10.6084/m9.figshare.14322270.v1
title: Correlation of Thyroid Imaging Reporting and Data System [TI-RADS] and fine needle aspiration: experience in 1,000 nodules

description: ABSTRACT Objective To correlate the Thyroid Imaging Reporting and Data System (TI-RADS) and the Bethesda system in reporting cytopathology in 1,000 thyroid nodules. Methods A retrospective study conducted from November 2011 to February 2014 that evaluated 1,000 thyroid nodules of 906 patients who underwent ultrasound exam and fine needle aspiration. Results A significant association was found between the TI-RADS outcome and Bethesda classification (p&lt;0.001). Most individuals with TI-RADS 2 or 3 had Bethesda 2 result (95.5% and 92.5%, respectively). Among those classified as TI-RADS 4C and 5, most presented Bethesda 6 (68.2% and 91.3%, respectively; p&lt;0.001). The proportion of malignancies among TI-RADS 2 was 0.8%, and TI-RADS 3 was 1.7%. Among those classified as TI-RADS 4A, proportion of malignancies was 16.0%, 43.2% in 4B, 72.7% in 4C and 91.3% among TI-RADS 5 (p&lt;0.001), showing clear association between TI-RADS and biopsy results. Conclusion The TI-RADS is appropriate to assess thyroid nodules and avoid unnecessary fine needle aspiration, as well as to assist in making decision about when this procedure should be performed.
DOI: 10.6084/m9.figshare.14322272
title: Endovascular revascularization of TASC C and D femoropopliteal occlusive disease using carbon dioxide as contrast

description: ABSTRACT Objective To analyze the results of ten angioplasties of TASC C and D femoropopliteal lesions using CO2 as primary contrast in patients with no formal contraindication to iodine, aiming to decrease allergic reactions and potential nephrotoxicity in high-risk patients. Methods We describe the results of ten angioplasties of TASC C and D femoropopliteal lesions using CO2 as primary contrast in patients with high risk for open revascularization and no formal contraindication to iodine. We analyzed feasibility of the procedures, complications, quality of the angiographic images, clinical and surgical outcomes, and costs of C and D lesions treated using CO2 as contrast medium. Results The use of CO2 in C and D lesions needed iodine complementation in most of the cases (nine cases) but decreased the potential nephrotoxicity of iodine contrast medium by the reduction of its volume in this group of high-risk patients. The extension of the arterial lesions was the factor that most contributed to the need for iodine supplementation due to the difficulty to visualize the refill after a long arterial occlusion. Conclusion The use of CO2 as contrast in patients with C and D lesions with no restriction for iodine contrast medium was an alternative that did not dismiss the need of iodine supplementation in most of the cases, but could decrease the potential nephrotoxicity of iodine constrast medium.