DOI: 10.5061/dryad.bj254
title: Data from: Malaria transmission potential could be reduced with current and future climate change

description: Several studies suggest the potential for climate change to increase
 malaria incidence in cooler, marginal transmission environments. However,
 the effect of increasing temperature in warmer regions where conditions
 currently support endemic transmission has received less attention. We
 investigate how increases in temperature from optimal conditions (27 °C to
 30 °C and 33 °C) interact with realistic diurnal temperature ranges
 (DTR: ± 0 °C, 3 °C, and 4.5 °C) to affect the ability of key vector
 species from Africa and Asia (Anopheles gambiae and An. stephensi) to
 transmit the human malaria parasite, Plasmodium falciparum. The effects of
 increasing temperature and DTR on parasite prevalence, parasite intensity,
 and mosquito mortality decreased overall vectorial capacity for both
 mosquito species. Increases of 3 °C from 27 °C reduced vectorial capacity
 by 51–89% depending on species and DTR, with increases in DTR alone
 potentially halving transmission. At 33 °C, transmission potential was
 further reduced for An. stephensi and blocked completely in An. gambiae.
 These results suggest that small shifts in temperature could play a
 substantial role in malaria transmission dynamics, yet few empirical or
 modeling studies consider such effects. They further suggest that rather
 than increase risk, current and future warming could reduce transmission
 potential in existing high transmission settings.
description: Malaria parasite data
 for Anopheles gambiaeThis data file includes
 data on malaria infection in individual mosquitoes. For each temperature
 treatment we dissected midguts (on day 7 post infection) or salivary
 glands (day 15 post infection) from 20 individual mosquitoes within each
 temperature treatment if numbers permitted. The "Oocyst_data"
 tab includes data on whether or not a mosquito had oocysts on its midgut
 and overall oocyst burden. The "Sporozoite_data" tab includes
 information on whether or not an individual mosquito had sporozoites in
 its salivary glands. The "Data codes" tab includes information
 describing each column and how it is coded across both the
 "Oocyst_data" and "Sporozoite_data"
 tabs.Anopheles_gambiae_parasitedata.xlsxMalaria parasite data for Anopheles stephensiThis data file includes data on malaria infection in individual mosquitoes. For each temperature treatment we dissected midguts (on day 7 post infection) or salivary glands (day 15 post infection) from 20 individual mosquitoes within each temperature treatment if numbers permitted. The "Oocyst_data" tab includes data on whether or not a mosquito had oocysts on its midgut and overall oocyst burden. The "Sporozoite_data" tab includes information on whether or not an individual mosquito had sporozoites in its salivary glands. The "Data codes" tab includes information describing each column and how it is coded across both the "Oocyst_data" and "Sporozoite_data" tabs.Anopheles_stephensi_parasitedata.xlsxMosquito Survival DataThis data file includes in the "Survival Data" tab the daily mortality events for the associated infection experiments. We have recorded number of mosquitoes alive vs. dead each day post-infection with human malaria. We also followed a blood-fed, uninfected control group to determine if the effects of temperature and diurnal temperature range had a different impact on the daily probability of mosquito survival for P. falciparum infected mosquitoes. Finally, we also recorded the number of mosquitoes that were dissected for midguts and salivary glands to assess parasite infection so that these cases could be censored in the downstream survival analysis. The "Data Codes" tab has descriptors for the various column headings and data labels.SurvivalData.xlsx