cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14319334
title: Non-recovery of renal function is a strong independent risk factor associated with mortality in AKI patients

description: ABSTRACT Introduction: Acute kidney injury (AKI) is a recurrent complication in the intensive care unit (ICU) and is associated with negative outcomes. Objective: To investigate factors associated with mortality in critically ill AKI patients in a South Brazilian ICU. Methods: The study was observational retrospective involving AKI patients admitted to the ICU between January 2011 and December 2016 of at least 18 years old upon admission and who remained in the ICU at least 48 hours. Comparisons between selected characteristics of survivor and non-survivor groups were done using univariate analysis; multivariate logistic regression was applied to determine factors associated with patient mortality. Results: Of 838 eligible patients, 613 participated in the study. Men represented the majority (61.2%) of the patients, the median age was 53 years, and the global mortality rate was 39.6% (n= 243). Non-recovery of renal function after AKI (OR= 92.7 [38.43 - 223.62]; p &lt;0.001), major surgery-associated AKI diagnosis (OR= 16.22 [3.49 - 75.38]; p &lt;0.001), and the use of vasoactive drugs during the ICU stay (OR = 11.49 [2.46 - 53.70]; p &lt;0.002) were the main factors independently associated with patient mortality. Conclusion: The mortality rate observed in this study was similar to that verified in other centers. Non-recovery of renal function was the variable most strongly associated with patient mortality, suggesting that the prevention of factors that aggravate or maintain the AKI episode should be actively identified and mitigated, possibly constituting an important strategy to reduce mortality in AKI patients.
DOI: 10.6084/m9.figshare.14319334.v1
title: Non-recovery of renal function is a strong independent risk factor associated with mortality in AKI patients

description: ABSTRACT Introduction: Acute kidney injury (AKI) is a recurrent complication in the intensive care unit (ICU) and is associated with negative outcomes. Objective: To investigate factors associated with mortality in critically ill AKI patients in a South Brazilian ICU. Methods: The study was observational retrospective involving AKI patients admitted to the ICU between January 2011 and December 2016 of at least 18 years old upon admission and who remained in the ICU at least 48 hours. Comparisons between selected characteristics of survivor and non-survivor groups were done using univariate analysis; multivariate logistic regression was applied to determine factors associated with patient mortality. Results: Of 838 eligible patients, 613 participated in the study. Men represented the majority (61.2%) of the patients, the median age was 53 years, and the global mortality rate was 39.6% (n= 243). Non-recovery of renal function after AKI (OR= 92.7 [38.43 - 223.62]; p &lt;0.001), major surgery-associated AKI diagnosis (OR= 16.22 [3.49 - 75.38]; p &lt;0.001), and the use of vasoactive drugs during the ICU stay (OR = 11.49 [2.46 - 53.70]; p &lt;0.002) were the main factors independently associated with patient mortality. Conclusion: The mortality rate observed in this study was similar to that verified in other centers. Non-recovery of renal function was the variable most strongly associated with patient mortality, suggesting that the prevention of factors that aggravate or maintain the AKI episode should be actively identified and mitigated, possibly constituting an important strategy to reduce mortality in AKI patients.
DOI: 10.6084/m9.figshare.14319337
title: Dietary intake of tyrosine and phenylalanine, and p-cresyl sulfate plasma levels in non-dialyzed patients with chronic kidney disease

description: ABSTRACT Background: Patients with chronic kidney disease (CKD) present an imbalance of the gut microbiota composition, leading to increased production of uremic toxins like p-cresyl sulfate (PCS), product from bacterial fermentation of the amino acids tyrosine (Tyr) and phenylalanine (Phe) from the diet. Thus, diet may be a determinant in the uremic toxins levels produced by the gut microbiota. The aim of this study was to evaluate the possible relationship between Tyr and Phe intake and PCS plasma levels in non-dialysis CKD patients. Methods: Twenty-seven non-dialysis CKD patients (stages 3 and 4) without previous nutritional intervention were evaluated. The dietary intake was evaluated using a 24-hour recall, 3-day food record and protein intake was also estimated by Protein Nitrogen Appearance (PNA). The plasma levels of PCS were measured using reverse phase high performance liquid chromatography. Results: The evaluated patients (GRF, 34.8 ± 12.4 mL/min, 54.2 ± 14.3 years, BMI, 29.3 ± 6.1 kg/m2) presented mean protein intake of 1.1 ± 0.5 g/kg/day), Tyr of 4.5 ± 2.4 g/day and Phe of 4.6 ± 2.5 g/day. PCS plasma levels (20.4 ± 15.5 mg/L) were elevated and positively associated with both, Tyr (r = 0.58, p = 0.002) and Phe intake (r = 0.53, p = 0.005), even after adjustments for eGFR and age. Conclusion: This study suggests that the diet is an important modulator of the uremic toxins plasma levels produced by the gut microbiota, in non-dialysis CKD patients.
DOI: 10.6084/m9.figshare.14319337.v1
title: Dietary intake of tyrosine and phenylalanine, and p-cresyl sulfate plasma levels in non-dialyzed patients with chronic kidney disease

description: ABSTRACT Background: Patients with chronic kidney disease (CKD) present an imbalance of the gut microbiota composition, leading to increased production of uremic toxins like p-cresyl sulfate (PCS), product from bacterial fermentation of the amino acids tyrosine (Tyr) and phenylalanine (Phe) from the diet. Thus, diet may be a determinant in the uremic toxins levels produced by the gut microbiota. The aim of this study was to evaluate the possible relationship between Tyr and Phe intake and PCS plasma levels in non-dialysis CKD patients. Methods: Twenty-seven non-dialysis CKD patients (stages 3 and 4) without previous nutritional intervention were evaluated. The dietary intake was evaluated using a 24-hour recall, 3-day food record and protein intake was also estimated by Protein Nitrogen Appearance (PNA). The plasma levels of PCS were measured using reverse phase high performance liquid chromatography. Results: The evaluated patients (GRF, 34.8 ± 12.4 mL/min, 54.2 ± 14.3 years, BMI, 29.3 ± 6.1 kg/m2) presented mean protein intake of 1.1 ± 0.5 g/kg/day), Tyr of 4.5 ± 2.4 g/day and Phe of 4.6 ± 2.5 g/day. PCS plasma levels (20.4 ± 15.5 mg/L) were elevated and positively associated with both, Tyr (r = 0.58, p = 0.002) and Phe intake (r = 0.53, p = 0.005), even after adjustments for eGFR and age. Conclusion: This study suggests that the diet is an important modulator of the uremic toxins plasma levels produced by the gut microbiota, in non-dialysis CKD patients.
DOI: 10.6084/m9.figshare.14319339
title: Cbfa1 expression in vascular smooth muscle cells may be elevated by increased nitric oxide/iNOS

description: ABSTRACT Introduction: Vascular calcification is a common complication of chronic kidney disease. Osteoblast differentiation factor (Cbfa1) is present in histologic sections of arteries from patients with end-stage renal disease. Vascular smooth muscle cells (VSMC) can dedifferentiate to osteoblast-like cells, possibly by up-regulation of Cbfa1. There is evidence that the production of nitric oxide (NO) may have an important role in the regulation of osteoblast metabolism. The aim of this study is to evaluate whether increased NO/iNOS expression causes an increase in cbfa1 expression in VSMC. Methods: VSMC were obtained from renal artery of Wistar male rats, treated for 72 hours with lipopolysaccharide (LPS), ß-glycerophosphate (BGF), a donor of phosphate and aminoguanidine (AG), an inhibitor of iNOS, in the following groups: CTL (control), LPS, BGF, LPS + BGF, and LPS + AG. NO synthesis was determined by chemiluminescence. Cbfa1 and iNOS mRNA expressions were analyzed by RT-PCR, Cbfa1 protein expression by immunohistochemistry and cellular viability by acridine orange. Results: Cbfa1 and iNOS mRNA expressions were higher in LPS and LPS+ BGF vs CTL (p &lt; 0.05), and they were lower in LPS+AG vs LPS (p &lt; 0.05). The Cbfa1 in the groups LPS and LPS+BGF also resulted in a higher value compared to CTL (p &lt; 0.05), and in LPS+AG it was lower compared to LPS (p &lt; 0.05). NO was higher in LPS and LPS+BGF compared to CTL group (p &lt; 0.05) and lower in LPS + AG compared to LPS group (p &lt; 0.05). Cellular viability showed no statistical difference among groups. Conclusion: This study showed that increased NO/iNOS expression causes an increase in cbfa1 expression in VSMC.
DOI: 10.6084/m9.figshare.14319339.v1
title: Cbfa1 expression in vascular smooth muscle cells may be elevated by increased nitric oxide/iNOS

description: ABSTRACT Introduction: Vascular calcification is a common complication of chronic kidney disease. Osteoblast differentiation factor (Cbfa1) is present in histologic sections of arteries from patients with end-stage renal disease. Vascular smooth muscle cells (VSMC) can dedifferentiate to osteoblast-like cells, possibly by up-regulation of Cbfa1. There is evidence that the production of nitric oxide (NO) may have an important role in the regulation of osteoblast metabolism. The aim of this study is to evaluate whether increased NO/iNOS expression causes an increase in cbfa1 expression in VSMC. Methods: VSMC were obtained from renal artery of Wistar male rats, treated for 72 hours with lipopolysaccharide (LPS), ß-glycerophosphate (BGF), a donor of phosphate and aminoguanidine (AG), an inhibitor of iNOS, in the following groups: CTL (control), LPS, BGF, LPS + BGF, and LPS + AG. NO synthesis was determined by chemiluminescence. Cbfa1 and iNOS mRNA expressions were analyzed by RT-PCR, Cbfa1 protein expression by immunohistochemistry and cellular viability by acridine orange. Results: Cbfa1 and iNOS mRNA expressions were higher in LPS and LPS+ BGF vs CTL (p &lt; 0.05), and they were lower in LPS+AG vs LPS (p &lt; 0.05). The Cbfa1 in the groups LPS and LPS+BGF also resulted in a higher value compared to CTL (p &lt; 0.05), and in LPS+AG it was lower compared to LPS (p &lt; 0.05). NO was higher in LPS and LPS+BGF compared to CTL group (p &lt; 0.05) and lower in LPS + AG compared to LPS group (p &lt; 0.05). Cellular viability showed no statistical difference among groups. Conclusion: This study showed that increased NO/iNOS expression causes an increase in cbfa1 expression in VSMC.
DOI: 10.6084/m9.figshare.14319343.v1
title: Metabolic acidosis in hemodialysis: a neglected problem in Brazil

description: ABSTRACT Introduction: Metabolic acidosis is associated with the high mortality seen in hemodialysis patients. The panorama of metabolic acidosis in hemodialysis in Brazil is unclear since 1996 when the analysis of bicarbonate levels was no longer a compulsory exam. We aimed to establish the prevalence of metabolic acidosis in a hemodialysis population and analyze the factors associated with low bicarbonate levels. Methods: A cross-sectional study was carried out to assess the prevalence of metabolic acidosis in adults undergoing regular hemodialysis from January to April 2017, in four dialysis centers from Niteroi, Rio de Janeiro, Brazil, and surroundings. For blood gas analysis, samples of 2 mL were collected in heparinized syringes before a midweek dialysis session. Results: 384 patients with a mean age of 58.1 ± 15.8 years (54.5% men and 63.0%, non-white) were included. Approximately 30% had diabetes and 48%, hypertension. Nearly 88% used primary arteriovenous fistula as vascular access. The pre-dialysis mean serum tCO2 in the midweek session was 22.7 ± 3.0 mEq/L. The prevalence rate of serum bicarbonate below DOQI recommendation (22 mEq/L or higher) was 40.3%, and 6.5% had serum bicarbonate &lt; 18 mEq/L. The dialyzer use count and the use of low-flux dialyzers were negatively associated whereas age and the standard Kt/V values were positively associated with the serum bicarbonate levels. Conclusion: The findings were in agreement with global data reported in previous studies. However, because the sample was relatively small and non-representative of the Brazilian population, a more comprehensive study, addressing national data is necessary to substantiate our findings.
DOI: 10.6084/m9.figshare.14319343
title: Metabolic acidosis in hemodialysis: a neglected problem in Brazil

description: ABSTRACT Introduction: Metabolic acidosis is associated with the high mortality seen in hemodialysis patients. The panorama of metabolic acidosis in hemodialysis in Brazil is unclear since 1996 when the analysis of bicarbonate levels was no longer a compulsory exam. We aimed to establish the prevalence of metabolic acidosis in a hemodialysis population and analyze the factors associated with low bicarbonate levels. Methods: A cross-sectional study was carried out to assess the prevalence of metabolic acidosis in adults undergoing regular hemodialysis from January to April 2017, in four dialysis centers from Niteroi, Rio de Janeiro, Brazil, and surroundings. For blood gas analysis, samples of 2 mL were collected in heparinized syringes before a midweek dialysis session. Results: 384 patients with a mean age of 58.1 ± 15.8 years (54.5% men and 63.0%, non-white) were included. Approximately 30% had diabetes and 48%, hypertension. Nearly 88% used primary arteriovenous fistula as vascular access. The pre-dialysis mean serum tCO2 in the midweek session was 22.7 ± 3.0 mEq/L. The prevalence rate of serum bicarbonate below DOQI recommendation (22 mEq/L or higher) was 40.3%, and 6.5% had serum bicarbonate &lt; 18 mEq/L. The dialyzer use count and the use of low-flux dialyzers were negatively associated whereas age and the standard Kt/V values were positively associated with the serum bicarbonate levels. Conclusion: The findings were in agreement with global data reported in previous studies. However, because the sample was relatively small and non-representative of the Brazilian population, a more comprehensive study, addressing national data is necessary to substantiate our findings.
DOI: 10.6084/m9.figshare.14319345.v1
title: Therapy for persistent hypercalcemic hyperparathyroidism post-renal transplant: cinacalcet versus parathyroidectomy

description: ABSTRACT Background: Persistent hyperparathyroidism post-transplant is associated with increases in the incidence of cardiovascular events, fractures, and deaths. The aim of this study was to compare both therapeutic options available: parathyroidectomy (PTX) and the calcimimetic agent cinacalcet. Methods: A single center retrospective study including adult renal transplant recipients who developed hypercalcemia due to persistent hyperparathyroidism. Inclusion criteria: PTH &gt; 65 pg/mL with serum calcium &gt; 11.5 mg/dL at any time after transplant or serum calcium persistently higher than 10.2 mg/dL one year after transplant. Patients treated with cinacalcet (n=46) were compared to patients treated with parathyroidectomy (n=30). Follow-up period was one year. Clinical and laboratory data were analyzed to compare efficacy and safety of both therapeutic modalities. Results: PTX controlled calcemia faster (month 1 x month 6) and reached significantly lower levels at month 12 (9.1±1.2 vs 9.7±0.8 mg/dL, p &lt; 0.05); PTX patients showed significantly higher levels of serum phosphate (3.8±1.0 vs 2.9±0.5 mg/dL, p &lt; 0.05) and returned PTH to normal levels (45±51 pg/mL). Cinacalcet, despite controlling calcium and phosphate in the long term, decreased but did not correct PTH (197±97 pg/mL). The proportion of patients that remained with PTH above normal range was 95% in the cinacalcet group and 22% in the PTX group. Patients treated with cinacalcet had better renal function (creatinine 1.2±0.3 vs 1.7±0.7 mg/dL, p &lt; 0.05). Conclusions: Surgical treatment was superior to cinacalcet to correct the metabolic disorders of hyperparathyroidism despite being associated with worse renal function in the long term. Cinacalcet proved to be a safe and well tolerated drug.
DOI: 10.15468/dl.vx8ezn
title: Occurrence Download

description: A dataset containing 6597 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pseudogobio esocinus (Temminck & Schlegel, 1846)"
 ]
}

 The dataset includes 6597 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000484-190813142620410/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xl8zk7
title: Occurrence Download

description: A dataset containing 644 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Croton blanchetianus Baill.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 644 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035877-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ttkt4f
title: Occurrence Download

description: A dataset containing 1978 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Dendroctonus valens LeConte, 1859"
 ]
}

 The dataset includes 1978 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0084294-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.289ym2
title: Occurrence Download

description: A dataset containing 15665 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ambystoma tigrinum (Green, 1825)"
 ]
}

 The dataset includes 15665 records from 119 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0285328-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tt9mth
title: Occurrence Download

description: A dataset containing 34076 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Year 2010-2018",
 "HasCoordinate is true",
 "TaxonKey is Lanius schach Linnaeus, 1758"
 ]
}

 The dataset includes 34076 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006699-180412121330197/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xdfqvb
title: Occurrence Download

description: A dataset containing 333 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mikrogeophagus ramirezi (Myers & Harry, 1948)"
 ]
}

 The dataset includes 333 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0248908-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.1snzhu
title: Occurrence Download

description: A dataset containing 77 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "Locality is lake erie",
 "TaxonKey is Unionidae"
 ]
}

 The dataset includes 77 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007927-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.11352288
title: Focus Group Discussion with Policy Makers (Germany)

description: This material is a transcript of a group discussion conducted with policy makers on the topic of educational commons. The abbreviation UOS in the file name/identifier refers to the consortium partner providing the dataset.
DOI: 10.5281/zenodo.11352289
title: Focus Group Discussion with Policy Makers (Germany)

description: This material is a transcript of a group discussion conducted with policy makers on the topic of educational commons. The abbreviation UOS in the file name/identifier refers to the consortium partner providing the dataset.
DOI: 10.15468/dl.xb78j6
title: Occurrence Download

description: A dataset containing 2553032 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Geraniaceae"
 ]
}

 The dataset includes 2553032 records from 1962 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0304651-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17011573
title: Arabic Google Maps Reviews Dataset for Tourism in Saudi Arabia with Multi-Aspect Sentiment Annotations

description: This dataset contains 3,543 Arabic Google Maps reviews collected from various tourist attractions across Saudi Arabia, including parks, historical sites, museums, and recreational facilities. The dataset was created as part of a research study on aspect-based sentiment analysis (ABSA) to evaluate visitor experiences and provide insights for tourism development in alignment with Saudi Vision 2030.

 

Each review is annotated at the aspect level with sentiment polarity labels (positive, neutral, negative) across six key aspects:

 





Price




Overall Experience




Facilities




Staff & Service




Environment




Cleanliness



 

 

 

Key Features:

 

 





Language: Arabic




Total Records: 3,543 reviews




Source: Publicly available Google Maps reviews




Annotations: Conducted manually by two trained annotators with a Cohen’s Kappa score of 0.87, ensuring high reliability.




Format: Excel file (.xlsx) with structured columns for city, place name, review text, and aspect-based sentiment labels.




License: Creative Commons CC0 1.0 Universal



 

 

 

Potential Applications:

 

 





Developing and benchmarking Arabic NLP models.




Research on aspect-based sentiment analysis (ABSA).




Tourism analytics and policy-making support.




Applications in customer experience analysis for Arabic text.
DOI: 10.5281/zenodo.17011574
title: Arabic Google Maps Reviews Dataset for Tourism in Saudi Arabia with Multi-Aspect Sentiment Annotations

description: This dataset contains 3,543 Arabic Google Maps reviews collected from various tourist attractions across Saudi Arabia, including parks, historical sites, museums, and recreational facilities. The dataset was created as part of a research study on aspect-based sentiment analysis (ABSA) to evaluate visitor experiences and provide insights for tourism development in alignment with Saudi Vision 2030.

 

Each review is annotated at the aspect level with sentiment polarity labels (positive, neutral, negative) across six key aspects:

 





Price




Overall Experience




Facilities




Staff & Service




Environment




Cleanliness



 

 

 

Key Features:

 

 





Language: Arabic




Total Records: 3,543 reviews




Source: Publicly available Google Maps reviews




Annotations: Conducted manually by two trained annotators with a Cohen’s Kappa score of 0.87, ensuring high reliability.




Format: Excel file (.xlsx) with structured columns for city, place name, review text, and aspect-based sentiment labels.




License: Creative Commons CC0 1.0 Universal



 

 

 

Potential Applications:

 

 





Developing and benchmarking Arabic NLP models.




Research on aspect-based sentiment analysis (ABSA).




Tourism analytics and policy-making support.




Applications in customer experience analysis for Arabic text.