cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22188010.v1
title: Estimation of cancer incidence in the state of São Paulo, Brazil, based on real data

description: This study aims to evaluate the feasibility of applying a method of estimating the incidence of cancer to regions of the state of São Paulo, Brazil, from real data (not estimated) and retrospectively comparing the results obtained with the official estimates. A method based on mortality and on the incidence to mortality (I/M) ration was used according to sex, age, and tumor location. In the I/M numerator, new cases of cancer were used from the population records of Jaú and São Paulo from 2006-2010; in the denominator, deaths from 2006-2010 in the respective areas, extracted from the national mortality system. The estimates resulted from the multiplication of I/M by the number of cancer deaths in 2010 for each region. Population data from the 2010 Demographic Census were used to estimate incidence rates. For the adjustment by age, the world standard population was used. We calculated the relative differences between the gross incidence rates estimated in this study and the official ones. Age-adjusted cancer incidence rates were 260.9/100,000 for men and 216.6/100,000 for women. Prostate cancer was the most common in males, whereas breast cancer was most common in females. Differences between the rates of this study and the official rates were 3.3% and 1.5% for each sex. The estimated incidence was compatible with the officially presented state profile, indicating that the application of real data did not alter the morbidity profile, while it did indicate different risk magnitudes. Despite the over-representativeness of the cancer registry with greater population coverage, the selected method proved feasible to point out different patterns within the state.
DOI: 10.6084/m9.figshare.23702137
title: RCC - Roller-Compacted Concrete with hematite aggregate

description: Abstract RCC using hematite as an aggregate has interesting characteristics for use in massive structures or structures for radiation shielding. In Brazil, there is a considerable amount of hematite ore tailings without practical use, which makes this material an environmental problem and a matter of public safety. Thus, the search for alternatives to use these tailings is a priority environmental concern. An RCC containment dam with hematite aggregate was constructed to protect the basin of the Barao de Cocais River, including the city of Barao de Cocais in the State of Minas Gerais in Brazil, from a possible rupture of the Sul Superior tailings dam in the Congo Soco iron mine. Approximately 150,000 m3 of RCC was deposited in three months. In this article, the results of the technological control tests during the construction of the containment are presented and compared with the results of the cores extracted after the construction, showing their coherence and strength performance compared with RCC using conventional aggregate. Also, studies related to the performance of radiation shielding of this RCC are presented. An attenuation of 10% of 1.6 MeV gamma radiation in relation to conventional concrete was observed.
DOI: 10.6084/m9.figshare.23702137.v1
title: RCC - Roller-Compacted Concrete with hematite aggregate

description: Abstract RCC using hematite as an aggregate has interesting characteristics for use in massive structures or structures for radiation shielding. In Brazil, there is a considerable amount of hematite ore tailings without practical use, which makes this material an environmental problem and a matter of public safety. Thus, the search for alternatives to use these tailings is a priority environmental concern. An RCC containment dam with hematite aggregate was constructed to protect the basin of the Barao de Cocais River, including the city of Barao de Cocais in the State of Minas Gerais in Brazil, from a possible rupture of the Sul Superior tailings dam in the Congo Soco iron mine. Approximately 150,000 m3 of RCC was deposited in three months. In this article, the results of the technological control tests during the construction of the containment are presented and compared with the results of the cores extracted after the construction, showing their coherence and strength performance compared with RCC using conventional aggregate. Also, studies related to the performance of radiation shielding of this RCC are presented. An attenuation of 10% of 1.6 MeV gamma radiation in relation to conventional concrete was observed.
DOI: 10.6084/m9.figshare.23702139
title: Management of absenteeism in primary care services in a medium-sized city in Brazil

description: Abstract Through the lens of absenteeism, this article describes and analyzes the consultation scheduling and appointment process in Ribeirão Preto, São Paulo, Brazil. Based on primary health care scheduling and appointment process maps, we conducted interviews with coordinators of the Municipal Health Department and managers of primary care clinics and family health clinics. Adopting a qualitative approach, we identified the characteristics, peculiarities, and possibilities related to the organization of scheduling and appointments. The results are presented under the following thematic categories: schedule management, welcoming, information and communication technologies, unit model, urgent care, and infrastructure and human resources. The results of this work can help local health managers in implementing evaluation processes and the continuous improvement in primary care services.
DOI: 10.6084/m9.figshare.23702139.v1
title: Management of absenteeism in primary care services in a medium-sized city in Brazil

description: Abstract Through the lens of absenteeism, this article describes and analyzes the consultation scheduling and appointment process in Ribeirão Preto, São Paulo, Brazil. Based on primary health care scheduling and appointment process maps, we conducted interviews with coordinators of the Municipal Health Department and managers of primary care clinics and family health clinics. Adopting a qualitative approach, we identified the characteristics, peculiarities, and possibilities related to the organization of scheduling and appointments. The results are presented under the following thematic categories: schedule management, welcoming, information and communication technologies, unit model, urgent care, and infrastructure and human resources. The results of this work can help local health managers in implementing evaluation processes and the continuous improvement in primary care services.
DOI: 10.6084/m9.figshare.23702140
title: Histopathological changes of lymphatic malformation after bleomycin injection

description: ABSTRACT Lymphatic malformation is a rare orbital tumor that used to be treated surgically, with high complication rates, or recently with intralesional bleomycin injection. We report for the first time the histopathological changes of eyelid lymphatic malformation after water-soluble intralesional bleomycin injection in a 20-year-old woman who had unsuccessful orbital surgical debulking during childhood. The changes confirmed the assumption of fibrosis induced by intralesional bleomycin injection. The minimal bleeding during surgical intervention made it much easier than the usual lymphatic malformation bloody procedure, without postoperative recurrences and with favorable aesthetic outcomes.
DOI: 10.6084/m9.figshare.23702140.v1
title: Histopathological changes of lymphatic malformation after bleomycin injection

description: ABSTRACT Lymphatic malformation is a rare orbital tumor that used to be treated surgically, with high complication rates, or recently with intralesional bleomycin injection. We report for the first time the histopathological changes of eyelid lymphatic malformation after water-soluble intralesional bleomycin injection in a 20-year-old woman who had unsuccessful orbital surgical debulking during childhood. The changes confirmed the assumption of fibrosis induced by intralesional bleomycin injection. The minimal bleeding during surgical intervention made it much easier than the usual lymphatic malformation bloody procedure, without postoperative recurrences and with favorable aesthetic outcomes.
DOI: 10.6084/m9.figshare.23702142
title: SURGICAL TREATMENT OF CLAVICLE FRACTURES: A DESCRIPTIVE ANALYSIS OF 88 CASES

description: ABSTRACT Clavicle fractures are one of the most common types of bone injuries in adults. Recently, the treatment protocol for these fractures has undergone changes. Objective: To better understand the epidemiological and behavioral profile of these lesions when they require surgical treatment. Methods: This is an analysis of a series of cases. Our sample included individuals undergoing surgical treatment for clavicle fractures. Results: In total, 88 subjects fulfilled the predetermined criteria. Among these, 75 (85.22%) were male; automobile accidents corresponded to the largest etiological group, reaching 48% of prevalence; there was a slight predominance of the right side, totaling 45 cases (51%); most fractures were classified as Allman type I; an infection rate was observed in 1.13% of the cases; and the development of pseudarthrosis was identified in 2.27% of the patients. Conclusion: The incidence of clavicle fracture is higher in young men, mainly caused by car accidents, being mostly located in the middle third. No statistical significance was found between the synthesis material data and the postoperative complication rate, revealing the absence of risk superiority between the different types of surgical approaches used. Level of Evidence IV, Case Series.
DOI: 10.6084/m9.figshare.23702142.v1
title: SURGICAL TREATMENT OF CLAVICLE FRACTURES: A DESCRIPTIVE ANALYSIS OF 88 CASES

description: ABSTRACT Clavicle fractures are one of the most common types of bone injuries in adults. Recently, the treatment protocol for these fractures has undergone changes. Objective: To better understand the epidemiological and behavioral profile of these lesions when they require surgical treatment. Methods: This is an analysis of a series of cases. Our sample included individuals undergoing surgical treatment for clavicle fractures. Results: In total, 88 subjects fulfilled the predetermined criteria. Among these, 75 (85.22%) were male; automobile accidents corresponded to the largest etiological group, reaching 48% of prevalence; there was a slight predominance of the right side, totaling 45 cases (51%); most fractures were classified as Allman type I; an infection rate was observed in 1.13% of the cases; and the development of pseudarthrosis was identified in 2.27% of the patients. Conclusion: The incidence of clavicle fracture is higher in young men, mainly caused by car accidents, being mostly located in the middle third. No statistical significance was found between the synthesis material data and the postoperative complication rate, revealing the absence of risk superiority between the different types of surgical approaches used. Level of Evidence IV, Case Series.
DOI: 10.6084/m9.figshare.22132358
title: Family grief during the COVID-19 pandemic: a meta-synthesis of qualitative studies

description: The COVID-19 pandemic has led to a public health crisis, with increases in the number of deaths. As a result, the number of bereaved people has increased significantly. In addition, the measures adopted to control the spread of virus have triggered changes in the subjective and collective bereavement experiences. This systematic literature review aims to summarize and reinterpret the results of qualitative studies on the experience of losing family members during the pandemic by a thematic synthesis. The searches were performed in the Web of Science, Scopus, PubMed/MEDLINE, CINAHL, PsycINFO, and LILACS databases. Among 602 articles identified, 14 were included. Evidence was assessed using the Critical Appraisal Skills Programme tool. Two descriptive themes related to the objective were elaborated in addition to one analytical theme, namely: “Pandemic grief: lonely and unresolved”. These themes proved to be interrelated and indicate that experiences of loss in this context were negatively impacted by the imperatives of physical distance, restriction of hospital visits, technology-mediated communication, and prohibition or restriction of funerals. These changes resulted in experiences marked by feelings of loneliness and helplessness, which should be considered when planning intervention strategies that favor communication between family members with the afflicted loved one and with the health care team, enabling welcoming and creating alternatives for farewell rituals. The findings may support further research to test intervention protocols, especially to guide public policies and promote psychological support to bereaved family members after their loss.
DOI: 10.6084/m9.figshare.22132358.v1
title: Family grief during the COVID-19 pandemic: a meta-synthesis of qualitative studies

description: The COVID-19 pandemic has led to a public health crisis, with increases in the number of deaths. As a result, the number of bereaved people has increased significantly. In addition, the measures adopted to control the spread of virus have triggered changes in the subjective and collective bereavement experiences. This systematic literature review aims to summarize and reinterpret the results of qualitative studies on the experience of losing family members during the pandemic by a thematic synthesis. The searches were performed in the Web of Science, Scopus, PubMed/MEDLINE, CINAHL, PsycINFO, and LILACS databases. Among 602 articles identified, 14 were included. Evidence was assessed using the Critical Appraisal Skills Programme tool. Two descriptive themes related to the objective were elaborated in addition to one analytical theme, namely: “Pandemic grief: lonely and unresolved”. These themes proved to be interrelated and indicate that experiences of loss in this context were negatively impacted by the imperatives of physical distance, restriction of hospital visits, technology-mediated communication, and prohibition or restriction of funerals. These changes resulted in experiences marked by feelings of loneliness and helplessness, which should be considered when planning intervention strategies that favor communication between family members with the afflicted loved one and with the health care team, enabling welcoming and creating alternatives for farewell rituals. The findings may support further research to test intervention protocols, especially to guide public policies and promote psychological support to bereaved family members after their loss.
DOI: 10.18419/darus-2244
title: Replication Data for: "A flavin-inspired covalent organic framework for photocatalytic alcohol oxidation"

description: Covalent organic frameworks (COFs) offer a number of key properties that predestine them to be used as heterogeneous photocatalysts, including intrinsic porosity, long-range order, and light absorption. Since COFs can be constructed from a practically unlimited library of organic building blocks, these properties can be precisely tuned by choosing suitable linkers. Herein, we report the construction and use of a novel COF (FEAx-COF) photocatalyst, inspired by natural flavin cofactors. We show that the functionality of the alloxazine chromophore incorporated into the COF backbone is retained and study the effects of this heterogenization approach by comparison with similar molecular photocatalysts. We find that the integration of alloxazine chromophores into the framework significantly extends the absorption spectrum into the visible range, allowing for photocatalytic oxidation of benzylic alcohols to aldehydes even with low-energy visible light. In addition, the activity of the heterogeneous COF photocatalyst is less dependent on the chosen solvent, making it more versatile compared to molecular alloxazines. Finally, the use of oxygen as the terminal oxidant renders FEAx-COF a promising and “green” heterogeneous photocatalyst. All primary data files of measurements and processed data of the journal article mentioned under related publications from Lotsch group can be found here. The dataset contains data for the following analytical techniques: SEM, TEM, XPRD, scXRD, NMR, IR, UV-Vis, Sorption.
DOI: 10.6084/m9.figshare.23702148
title: Analysis of antimicrobial efficacy of sodium hypochlorite and ozonated water against biofilm in oval canals

description: Abstract This in vitro study compared the antimicrobial efficacy of 2.5% sodium hypochlorite (NaOCl) and 8 µg/mL ozonated water agitated by passive ultrasonic irrigation (PUI) or PUI combined with EndoActivator (EA) against mature multispecies biofilm. One hundred and five oval-shaped mandibular premolars were instrumented, sterilized, and inoculated with Enterococcus faecalis, Candida albicans, and Staphylococcus aureus, divided into: control group - saline; O3 group - ozonated water; O3 PUI group - ozonated water with PUI agitation; O3 PUI+EA group - ozonated water with PUI+EA agitation; NaOCl group - NaOCl; NaOCl PUI group - NaOCl with PUI agitation; and NaOCl PUI+EA group - NaOCl with PUI+EA agitation. Microbiological samples were collected before (S1) and after (S2) the disinfection procedures and the data were statistically analyzed using the Kruskal-Wallis test. In the culture method, there was significant disinfection in the O3 PUI+EA, NaOCl, NaOCl PUI, and NaOCl PUI+EA groups (p˂0.05). The combination of NaOCl with PUI+EA reduced microbial counts to zero (p˂0.05). In the qPCR method, there was a significant reduction in the total count of viable microorganisms in the O3 PUI, O3 PUI+EA, NaOCl, NaOCl PUI, and NaOCl PUI+EA groups (p˂0.05). It can be concluded that 2.5% NaOCl with and without agitation, as well as 8 µg/mL ozonated water with its action enhanced by the agitation techniques, were effective in root canal disinfection, and their antimicrobial efficacy is related to the microorganisms present in the biofilm.
DOI: 10.6084/m9.figshare.23702148.v1
title: Analysis of antimicrobial efficacy of sodium hypochlorite and ozonated water against biofilm in oval canals

description: Abstract This in vitro study compared the antimicrobial efficacy of 2.5% sodium hypochlorite (NaOCl) and 8 µg/mL ozonated water agitated by passive ultrasonic irrigation (PUI) or PUI combined with EndoActivator (EA) against mature multispecies biofilm. One hundred and five oval-shaped mandibular premolars were instrumented, sterilized, and inoculated with Enterococcus faecalis, Candida albicans, and Staphylococcus aureus, divided into: control group - saline; O3 group - ozonated water; O3 PUI group - ozonated water with PUI agitation; O3 PUI+EA group - ozonated water with PUI+EA agitation; NaOCl group - NaOCl; NaOCl PUI group - NaOCl with PUI agitation; and NaOCl PUI+EA group - NaOCl with PUI+EA agitation. Microbiological samples were collected before (S1) and after (S2) the disinfection procedures and the data were statistically analyzed using the Kruskal-Wallis test. In the culture method, there was significant disinfection in the O3 PUI+EA, NaOCl, NaOCl PUI, and NaOCl PUI+EA groups (p˂0.05). The combination of NaOCl with PUI+EA reduced microbial counts to zero (p˂0.05). In the qPCR method, there was a significant reduction in the total count of viable microorganisms in the O3 PUI, O3 PUI+EA, NaOCl, NaOCl PUI, and NaOCl PUI+EA groups (p˂0.05). It can be concluded that 2.5% NaOCl with and without agitation, as well as 8 µg/mL ozonated water with its action enhanced by the agitation techniques, were effective in root canal disinfection, and their antimicrobial efficacy is related to the microorganisms present in the biofilm.
DOI: 10.6084/m9.figshare.23702154
title: Cardiorespiratory/sedative effects of a peptide identified in crotalic venom compared to acepromazine and xylazine in horses

description: ABSTRACT The purpose of this study was to investigate whether intravenous crotalphine produces significant sedation, as well as physiological changes, in healthy standing horses. Six mares, aged 8 years and weighing 415kg underwent three different treatments in a crossover design: TA (acepromazine: 50μg.kg-1), TC (crotalphine: 0.01μg.kg-1) and TX (xylazine: 1000μg.kg-1), intravenously. At various time points over 60 minutes, physiologic variables were recorded: heart rate, respiratory rate, and rectal temperature. The head height from the ground (HHG) was evaluated in centimeters. Data were analyzed using ANOVA followed by Dunnett’s test or Friedman followed by Dunn’s test, under 5% significance. Heart rate decreased significantly at M5 and M10 compared with Mb in TX (28±7, 26±6 and 40±8 beats/minute-1, respectively; p=0.0004). Respiratory rate and rectal temperature did not differ among groups or time points. The HHG significantly decreased in all groups compared with Mb at various time points (p&lt;0.0001). In conclusion, crotalphine did not produce reliable and durable sedation in healthy standing mares and did not influence cardiorespiratory variables in a clinically relevant manner.
DOI: 10.6084/m9.figshare.23702154.v1
title: Cardiorespiratory/sedative effects of a peptide identified in crotalic venom compared to acepromazine and xylazine in horses

description: ABSTRACT The purpose of this study was to investigate whether intravenous crotalphine produces significant sedation, as well as physiological changes, in healthy standing horses. Six mares, aged 8 years and weighing 415kg underwent three different treatments in a crossover design: TA (acepromazine: 50μg.kg-1), TC (crotalphine: 0.01μg.kg-1) and TX (xylazine: 1000μg.kg-1), intravenously. At various time points over 60 minutes, physiologic variables were recorded: heart rate, respiratory rate, and rectal temperature. The head height from the ground (HHG) was evaluated in centimeters. Data were analyzed using ANOVA followed by Dunnett’s test or Friedman followed by Dunn’s test, under 5% significance. Heart rate decreased significantly at M5 and M10 compared with Mb in TX (28±7, 26±6 and 40±8 beats/minute-1, respectively; p=0.0004). Respiratory rate and rectal temperature did not differ among groups or time points. The HHG significantly decreased in all groups compared with Mb at various time points (p&lt;0.0001). In conclusion, crotalphine did not produce reliable and durable sedation in healthy standing mares and did not influence cardiorespiratory variables in a clinically relevant manner.
DOI: 10.6084/m9.figshare.23702149
title: Comparison of Cardioplegic Solutions in Coronary Bypass Surgery Over Autophagy and Apoptosis Mechanisms

description: Abstract Background Coronary artery disease (CAD) due to myocardial ischemia causes permanent loss of heart tissue. Objectives We aimed to demonstrate the possible damage to the myocardium at the molecular level through the mechanisms of autophagy and apoptosis in coronary bypass surgery patients. Methods One group was administered a Custodiol cardioplegia solution, and the other group was administered a Blood cardioplegia solution. Two myocardial samples were collected from each patient during the operation, just before cardiac arrest and after the aortic cross-clamp was released. The expressions of autophagy and apoptosis markers were evaluated. The level of statistical significance adopted was 5%. Results The expression of the BECLIN gene was significant in the myocardial tissues in the BC group (p=0.0078). CASPASE 3, 8, and 9 gene expression levels were significantly lower in the CC group. Postoperative TnT levels were significantly different between the groups (p=0.0072). CASPASE 8 and CASPASE 9 gene expressions were similar before and after aortic cross-clamping (p=0.8552, p=0.8891). In the CC group, CASPASE 3, CASPASE 8, and CASPASE 9 gene expression levels were not found to be significantly different in tissue samples taken after aortic cross-clamping (p=0.7354, p=0.0758, p=0.4128, respectively). Conclusions With our findings, we believe that CC and BC solutions do not have a significant difference in terms of myocardial protection during bypass operations.