cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4537104
title: Dataset from Garatti A, D'Ovidio M, Saitto G, Daprati A, Canziani A, Mossuto E, D'Oria V, Scarpanti M, De Vincentiis C, Parolari A, Menicanti L. Coronary artery bypass grafting in patients with concomitant solid tumours: early and long-term results. Eur J Cardiothorac Surg. 2020 Sep 1;58(3):528-536. doi: 10.1093/ejcts/ezaa114. PMID: 32474575.

description: Dataset from the article Garatti A, D'Ovidio M, Saitto G, Daprati A, Canziani A, Mossuto E, D'Oria V, Scarpanti M, De Vincentiis C, Parolari A, Menicanti L. Coronary artery bypass grafting in patients with concomitant solid tumours: early and long-term results. Eur J Cardiothorac Surg. 2020 Sep 1;58(3):528-536. doi: 10.1093/ejcts/ezaa114. PMID: 32474575. <strong>Abstract</strong> <strong>Objectives: </strong>Our goal was to analyse a consecutive series of patients with solid organ tumours undergoing coronary artery bypass grafting (CABG) by defining the risk factors for early and long-term outcomes. <strong>Methods: </strong>Between 2005 and 2016, a consecutive series of 4079 patients underwent isolated CABG at our institution. Of 103 patients (2.5%) with active malignancy, we enrolled 82 patients (mean age 71 ± 7 years) with solid organ tumours, divided into 4 subgroups: lung (9 patients-11%), gastroenteric (16 patients-20%), urinary (48 patients-58%) and other solid tumours (9 patients-11%). A deterministic record linkage between the clinical database and the National Hospital Information System allowed identification of long-term survival rates and freedom from major adverse cardiovascular events (acute myocardial infarction, repeated admissions for percutaneous coronary intervention and heart failure). <strong>Results: </strong>The most common forms of cancer were prostate, colon and carcinoma of the lung. Compared to patients without cancer, patients with neoplasms were significantly older and had a higher rate of comorbidities, without significant differences among the cancer subgroups. The 30-day mortality rate was significantly higher in patients with cancer compared to those without cancer (4.9% vs 1.8%). However, on logistic regression analysis, cancer was an independent risk factor for postoperative pulmonary dysfunction but not for in-hospital death. The median follow-up time was 58 ± 12 months. The overall 5-year survival rate was 60% [95% confidence interval (CI) 47-71%], with a dismal 32% (95% CI 5-65%) survival rate among patients who had lung tumours only. The 5-year freedom from major adverse cardiovascular events was 64% (95% CI 52-74%), without significant differences among subgroups, and was comparable to that of the non-cancer population. Resolution of coronary heart disease allowed safe cancer surgical resection in 80% of the population. <strong>Conclusions: </strong>Based on the results from the present study, CABG should not be denied to patients with solid organ tumours by claiming a worse prognosis or less graft durability. Further studies with larger numbers are warranted.
DOI: 10.5281/zenodo.4537103
title: Dataset from Garatti A, D'Ovidio M, Saitto G, Daprati A, Canziani A, Mossuto E, D'Oria V, Scarpanti M, De Vincentiis C, Parolari A, Menicanti L. Coronary artery bypass grafting in patients with concomitant solid tumours: early and long-term results. Eur J Cardiothorac Surg. 2020 Sep 1;58(3):528-536. doi: 10.1093/ejcts/ezaa114. PMID: 32474575.

description: Dataset from the article Garatti A, D'Ovidio M, Saitto G, Daprati A, Canziani A, Mossuto E, D'Oria V, Scarpanti M, De Vincentiis C, Parolari A, Menicanti L. Coronary artery bypass grafting in patients with concomitant solid tumours: early and long-term results. Eur J Cardiothorac Surg. 2020 Sep 1;58(3):528-536. doi: 10.1093/ejcts/ezaa114. PMID: 32474575. <strong>Abstract</strong> <strong>Objectives: </strong>Our goal was to analyse a consecutive series of patients with solid organ tumours undergoing coronary artery bypass grafting (CABG) by defining the risk factors for early and long-term outcomes. <strong>Methods: </strong>Between 2005 and 2016, a consecutive series of 4079 patients underwent isolated CABG at our institution. Of 103 patients (2.5%) with active malignancy, we enrolled 82 patients (mean age 71 ± 7 years) with solid organ tumours, divided into 4 subgroups: lung (9 patients-11%), gastroenteric (16 patients-20%), urinary (48 patients-58%) and other solid tumours (9 patients-11%). A deterministic record linkage between the clinical database and the National Hospital Information System allowed identification of long-term survival rates and freedom from major adverse cardiovascular events (acute myocardial infarction, repeated admissions for percutaneous coronary intervention and heart failure). <strong>Results: </strong>The most common forms of cancer were prostate, colon and carcinoma of the lung. Compared to patients without cancer, patients with neoplasms were significantly older and had a higher rate of comorbidities, without significant differences among the cancer subgroups. The 30-day mortality rate was significantly higher in patients with cancer compared to those without cancer (4.9% vs 1.8%). However, on logistic regression analysis, cancer was an independent risk factor for postoperative pulmonary dysfunction but not for in-hospital death. The median follow-up time was 58 ± 12 months. The overall 5-year survival rate was 60% [95% confidence interval (CI) 47-71%], with a dismal 32% (95% CI 5-65%) survival rate among patients who had lung tumours only. The 5-year freedom from major adverse cardiovascular events was 64% (95% CI 52-74%), without significant differences among subgroups, and was comparable to that of the non-cancer population. Resolution of coronary heart disease allowed safe cancer surgical resection in 80% of the population. <strong>Conclusions: </strong>Based on the results from the present study, CABG should not be denied to patients with solid organ tumours by claiming a worse prognosis or less graft durability. Further studies with larger numbers are warranted.
DOI: 10.5281/zenodo.4526196
title: Dataset related to the article "Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease"

description: This record contains raw data related to the article "Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease" ABSTRACT <strong>Introduction: </strong>Osteopontin (OPN) is involved in ectopic calcification. Its circulating form is upregulated in coronary artery disease (CAD) patients. Circulating OPN levels positively correlate with oxidative stress, one of the major triggers of endothelial dysfunction. Endothelial dysfunction is, in turn, associated with reduced nitric oxide (NO) bioavailability due to the impaired arginine pathway. The aim of this study was to better understand the correlations between OPN, oxidative stress markers, and the arginine pathway metabolites. <strong>Methods and results: </strong>ELISA and mass spectrometry techniques have been used to evaluate circulating OPN and arginine pathway/oxidative stress metabolites, respectively, in twenty-five control subjects and thirty-three patients with overt atherosclerosis. OPN positively correlates with 2,3-dinor-8isoPGF2a levels (<em>p</em> = 0.02), ornithine (<em>p</em> = 0.01), ADMA (<em>p</em> = 0.001), SDMA (<em>p</em> = 0.03), and citrulline (<em>p</em> = 0.008) levels only in CAD patients. In addition, citrulline positively correlated with ADMA (<em>p</em> = 0.02) levels, possibly as result of other sources of citrulline biosynthetic pathways. <strong>Conclusion: </strong>The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients. However, further studies are needed to verify the cause-effect relationship between OPN, oxidative stress, and arginine/NO pathway dysregulation.
description: This work was supported by the Italian Ministry of Health funds (Ricerca Corrente: RC2016-BIO34-2627243 and RC2019-CA1A-2755299) and by Fondazione Gigi e Pupa Ferrari ONLUS (FPF-14).
DOI: 10.5281/zenodo.4526195
title: Dataset related to the article "Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease"

description: This record contains raw data related to the article "Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease" ABSTRACT <strong>Introduction: </strong>Osteopontin (OPN) is involved in ectopic calcification. Its circulating form is upregulated in coronary artery disease (CAD) patients. Circulating OPN levels positively correlate with oxidative stress, one of the major triggers of endothelial dysfunction. Endothelial dysfunction is, in turn, associated with reduced nitric oxide (NO) bioavailability due to the impaired arginine pathway. The aim of this study was to better understand the correlations between OPN, oxidative stress markers, and the arginine pathway metabolites. <strong>Methods and results: </strong>ELISA and mass spectrometry techniques have been used to evaluate circulating OPN and arginine pathway/oxidative stress metabolites, respectively, in twenty-five control subjects and thirty-three patients with overt atherosclerosis. OPN positively correlates with 2,3-dinor-8isoPGF2a levels (<em>p</em> = 0.02), ornithine (<em>p</em> = 0.01), ADMA (<em>p</em> = 0.001), SDMA (<em>p</em> = 0.03), and citrulline (<em>p</em> = 0.008) levels only in CAD patients. In addition, citrulline positively correlated with ADMA (<em>p</em> = 0.02) levels, possibly as result of other sources of citrulline biosynthetic pathways. <strong>Conclusion: </strong>The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients. However, further studies are needed to verify the cause-effect relationship between OPN, oxidative stress, and arginine/NO pathway dysregulation.
description: This work was supported by the Italian Ministry of Health funds (Ricerca Corrente: RC2016-BIO34-2627243 and RC2019-CA1A-2755299) and by Fondazione Gigi e Pupa Ferrari ONLUS (FPF-14).
DOI: 10.20351/29he20050104
title: TOMODEC Cruise, RV Hespérides

description: TOMODEC Cruise (29HE20050104) carried out on the Research Vessel Hespérides in 2005
DOI: 10.5281/zenodo.4522250
title: Dataset related to the article: "A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema"

description: This record contains raw data related to the article: "A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema". The study is multicentric. Data collected by Centro Cardiologico Monzino IRCCS. Abstract: <strong>Background: </strong>The acute respiratory distress syndrome (ARDS) and cardiogenic pulmonary edema (CPE) are both characterized by an increase in lung edema that can be measured by computed tomography (CT). The aim of this study was to compare possible differences between patients with ARDS and CPE in the morphologic pattern, the aeration, and the amount and distribution of edema within the lung. <strong>Methods: </strong>Lung CT was performed at a mean positive end-expiratory pressure level of 5 cm H2O in both groups. The morphological evaluation was performed by two radiologists, while the quantitative evaluation was performed by a dedicated software. <strong>Results: </strong>A total of 60 patients with ARDS (20 mild, 20 moderate, 20 severe) and 20 patients with CPE were enrolled. The ground-glass attenuation regions were similarly present among the groups, 8 (40%), 8 (40%), 14 (70%), and 10 (50%), while the airspace consolidations were significantly more present in ARDS. The lung gas volume was significantly lower in severe ARDS compared to CPE (830 [462] vs 1120 [832] mL). Moving from the nondependent to the dependent lung regions, the not inflated lung tissue significantly increased, while the well inflated tissue decreased (ρ = 0.96-1.00, <em>P</em> &lt; .0001). Significant differences were found between ARDS and CPE mostly in dependent regions. In severe ARDS, the estimated edema was significantly higher, compared to CPE (757 [740] vs 532 [637] g). <strong>Conclusions: </strong>Both ARDS and CPE are characterized by a similar presence of ground-glass attenuation and different airspace consolidation regions. Acute respiratory distress syndrome has a higher amount of not inflated tissue and lower amount of well inflated tissue. However, the overall regional distribution is similar within the lung.
DOI: 10.5281/zenodo.4522249
title: Dataset related to the article: "A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema"

description: This record contains raw data related to the article: "A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema". The study is multicentric. Data collected by Centro Cardiologico Monzino IRCCS. Abstract: <strong>Background: </strong>The acute respiratory distress syndrome (ARDS) and cardiogenic pulmonary edema (CPE) are both characterized by an increase in lung edema that can be measured by computed tomography (CT). The aim of this study was to compare possible differences between patients with ARDS and CPE in the morphologic pattern, the aeration, and the amount and distribution of edema within the lung. <strong>Methods: </strong>Lung CT was performed at a mean positive end-expiratory pressure level of 5 cm H2O in both groups. The morphological evaluation was performed by two radiologists, while the quantitative evaluation was performed by a dedicated software. <strong>Results: </strong>A total of 60 patients with ARDS (20 mild, 20 moderate, 20 severe) and 20 patients with CPE were enrolled. The ground-glass attenuation regions were similarly present among the groups, 8 (40%), 8 (40%), 14 (70%), and 10 (50%), while the airspace consolidations were significantly more present in ARDS. The lung gas volume was significantly lower in severe ARDS compared to CPE (830 [462] vs 1120 [832] mL). Moving from the nondependent to the dependent lung regions, the not inflated lung tissue significantly increased, while the well inflated tissue decreased (ρ = 0.96-1.00, <em>P</em> &lt; .0001). Significant differences were found between ARDS and CPE mostly in dependent regions. In severe ARDS, the estimated edema was significantly higher, compared to CPE (757 [740] vs 532 [637] g). <strong>Conclusions: </strong>Both ARDS and CPE are characterized by a similar presence of ground-glass attenuation and different airspace consolidation regions. Acute respiratory distress syndrome has a higher amount of not inflated tissue and lower amount of well inflated tissue. However, the overall regional distribution is similar within the lung.
DOI: 10.20351/29he20050329
title: GEOPRICO Cruise, RV Hespérides

description: GEOPRICO Cruise (29HE20050329) carried out on the Research Vessel Hespérides in 2005
DOI: 10.20351/29he20000819
title: TECALB Cruise, RV Hespérides

description: TECALB Cruise (29HE20000819) carried out on the Research Vessel Hespérides in 2000
DOI: 10.15161/oar.it/73493
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.6084/m9.figshare.13947725
title: Supplementary Material for: Orofacial Granulomatosis and Crohn Disease: Coincidence or Pattern? A Systematic Review

description: <b><i>Background:</i></b> To systematically review all cases of orofacial granulomatosis (OFG) and evaluate the association between OFG and Crohn disease (CD). <b><i>Summary:</i></b> This review was conducted according to PRISMA guidelines and a search of the PubMed, MEDLINE, and Embase databases, and the Cochrane Library in March 2020, using keywords and MeSH terms associated with “orofacial granulomatosis,” “Crohn disease,” and their variants, with no language restrictions and across all age groups. All relevant articles were accessed in full text. Single case reports and articles on sarcoidosis, allergy, ulcerative colitis, and infectious diseases were excluded from the analysis. <b><i>Results:</i></b> We retrieved 507 reports on OFG. The mean age at onset was 23.3 years (range 2–89 years). A total of 240 (47.3%) females and 267 (52.6%) males were included. CD was present in 93 children aged &lt;16 years (68.3%) and in 43 adults (31.9%). In most cases, the OFG appeared before the CD. The most common clinical manifestations were intraoral mucosa abnormalities (<i>n</i> = 251; 49.5%), lower-lip swelling (<i>n</i> = 249; 49.1%), upper-lip swelling (<i>n</i> = 227; 44.7%), and gingivae (<i>n</i> = 193; 38.7%). Patients with concurrent CD were more likely to experience involvement of the buccal sulcus. <b><i>Key Messages:</i></b> OFG presents primarily as a solo entity. The OFG that was associated with CD was present in 93 children aged under 16 years (68.3%) and in 43 adults (31.9%). Childhood onset of OFG carries with it a higher risk of developing CD.
DOI: 10.6084/m9.figshare.13947725.v1
title: Supplementary Material for: Orofacial Granulomatosis and Crohn Disease: Coincidence or Pattern? A Systematic Review

description: <b><i>Background:</i></b> To systematically review all cases of orofacial granulomatosis (OFG) and evaluate the association between OFG and Crohn disease (CD). <b><i>Summary:</i></b> This review was conducted according to PRISMA guidelines and a search of the PubMed, MEDLINE, and Embase databases, and the Cochrane Library in March 2020, using keywords and MeSH terms associated with “orofacial granulomatosis,” “Crohn disease,” and their variants, with no language restrictions and across all age groups. All relevant articles were accessed in full text. Single case reports and articles on sarcoidosis, allergy, ulcerative colitis, and infectious diseases were excluded from the analysis. <b><i>Results:</i></b> We retrieved 507 reports on OFG. The mean age at onset was 23.3 years (range 2–89 years). A total of 240 (47.3%) females and 267 (52.6%) males were included. CD was present in 93 children aged &lt;16 years (68.3%) and in 43 adults (31.9%). In most cases, the OFG appeared before the CD. The most common clinical manifestations were intraoral mucosa abnormalities (<i>n</i> = 251; 49.5%), lower-lip swelling (<i>n</i> = 249; 49.1%), upper-lip swelling (<i>n</i> = 227; 44.7%), and gingivae (<i>n</i> = 193; 38.7%). Patients with concurrent CD were more likely to experience involvement of the buccal sulcus. <b><i>Key Messages:</i></b> OFG presents primarily as a solo entity. The OFG that was associated with CD was present in 93 children aged under 16 years (68.3%) and in 43 adults (31.9%). Childhood onset of OFG carries with it a higher risk of developing CD.
DOI: 10.20351/29he20000518
title: PARSIFAL Cruise, RV Hespérides

description: PARSIFAL Cruise (29HE20000518) carried out on the Research Vessel Hespérides in 2000
DOI: 10.6084/m9.figshare.13947617
title: Supplementary Material for: The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients

description: <b><i>Background:</i></b> There are great interindividual variations in the clinical efficacy of methotrexate (MTX) treatment and patients’ genetic background seems promising in its explanation. <b><i>Objectives:</i></b> The study aimed to test whether the polymorphism of annexin A6 (ANxA6) gene, a susceptibility factor for psoriasis, was associated with the clinical response to MTX therapy. <b><i>Methods:</i></b> A total of 325 patients enrolled in the study received oral MTX treatment, of whom 310 completed the 1-year study and performed the genotype analysis. They were defined as responders (a reduction of Psoriasis Area and Severity Index [PASI] score ≥75%) and nonresponders (a reduction of PASI &lt;50%) compared to baseline after 12 weeks of short-time therapy. On 1-year treatment, they were defined as responders if they achieved PASI75 and absolute PASI ≤3, otherwise as nonresponders. The genotypes of 4 single-nucleotide polymorphisms (SNPs) in the ANxA6 gene were verified using the Sequenom platform. Potential predictors associated with the treatment outcome of MTX were assessed by binary logistic regression. <b><i>Results:</i></b> We found significant associations for the ANxA6 SNPs of rs11960458, rs960709, and rs13168551 with psoriasis severity. Patients with rs11960458 CC genotype and rs960709 GG genotype showed higher percentages of PASI75 and improvement rates of PASI at 12 weeks. And on 1-year treatment, statistical difference occurred in rs11960458 rather than other SNPs compared between responders and nonresponders that the frequency of CC genotype was higher in responders (<i>p</i> = 0.019). After adjustment for potential confounders, patients with rs11960458 TT/CT genotype (at 12 weeks: OR 0.483, 95% CI 0.245–0.951, <i>p</i> = 0.035; at 1 year: OR 0.483, 95% CI 0.280–0.833, <i>p</i> = 0.009) were significantly more likely to not respond to MTX both on the short-term and long-term treatment, while rs960709 and rs13168551 polymorphisms were only associated with the short-term efficacy of MTX (<i>p</i> = 0.018 and <i>p</i> = 0.036, respectively). <b><i>Conclusions:</i></b> The CC ge­notype of ANxA6 (rs11960458) was significantly associated with a better response when compared to those patients with the TT/CT genotype, thus being a potential predictor for the clinical efficacy of MTX.