cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6318560.v1
title: Physicochemical characterization and comparison of labels of beef bouillon cubes

description: Abstract This study aimed at determining the centesimal composition, the energy value and the sodium content in beef bouillon cubes and compare them with the nutritional information by the manufacturer. Beef bouillon cube samples were collected in supermarkets in of the city of Limoeiro do Norte/CE, and the levels of nutrients were determined by official analysis methods. The physicochemical analyses carried out were moisture, lipids, proteins, fixed mineral residue, total carbohydrates and sodium content. The beef bouillon cubes analyzed showed a low moisture content (3.23 – 4.23 g/100 g) and high levels of lipids (19.72 – 20.05 g/100 g) and fixed mineral residue (53.24 – 57.61 g/100 g). When compared to the data reported on their labels, all the parameters were in smaller amounts than the ones declared in all analyzed brands. The average sodium content found in the samples ranged from 758.5 to 815.5 mg/serving of the product. Considering that the results were based on a portion of broth and that these amounts are related to half a cube of beef bouillon, it becomes quite alarming the amount of sodium available in this type of product, since the food prepared with this ingredient is usually eaten alongside other foods, which also contain sodium in their composition.
DOI: 10.6084/m9.figshare.6318557
title: Violence against the Brazilian elderlies: an analysis of hospitalizations

description: ABSTRACT Objective: to identify the prevalence of physical aggression and neglect and abandonment in the hospitalizations of Brazilian elderly people for violence and assault from 2008 to 2013 and the association of these causes with socio-demographic variables related to hospitalization. Method: quantitative, descriptive, cross-sectional study with elderlies hospitalized for assault. Inclusion criteria: to be 60 years old or over, to have been hospitalized in the Unified Health System (SUS) for assault or neglect and abandonment, between 2008 and 2013. The data were collected in February 2016, in Datasus database and descriptive and inferentially, using the Chi-square distribution, in the Epi Info 3.5.4 program. Results: the prevalence of hospitalizations due to assaults and violence prevailed among 60 and 69 years old men in the public sector. For abandonment and neglect, there was a higher prevalence in women, over 80 years old, in the public sector. Conclusion: nurses must be able to identify and prevent violence against the elderly.
DOI: 10.6084/m9.figshare.6318557.v1
title: Violence against the Brazilian elderlies: an analysis of hospitalizations

description: ABSTRACT Objective: to identify the prevalence of physical aggression and neglect and abandonment in the hospitalizations of Brazilian elderly people for violence and assault from 2008 to 2013 and the association of these causes with socio-demographic variables related to hospitalization. Method: quantitative, descriptive, cross-sectional study with elderlies hospitalized for assault. Inclusion criteria: to be 60 years old or over, to have been hospitalized in the Unified Health System (SUS) for assault or neglect and abandonment, between 2008 and 2013. The data were collected in February 2016, in Datasus database and descriptive and inferentially, using the Chi-square distribution, in the Epi Info 3.5.4 program. Results: the prevalence of hospitalizations due to assaults and violence prevailed among 60 and 69 years old men in the public sector. For abandonment and neglect, there was a higher prevalence in women, over 80 years old, in the public sector. Conclusion: nurses must be able to identify and prevent violence against the elderly.
DOI: 10.6084/m9.figshare.6318551
title: Welfare-friendly Products: availability, labeling and opinion of retailers in Curitiba, Southern Brazil,

description: Abstract: The market for welfare-friendly products (WFP) is increasing worldwide; however, there is a lack of information on this topic in Brazil. We investigated availability, product information and opinion of retailers about WFP in Curitiba, Southern Brazil. We visited 36 strategically located retailers, conducting product evaluation and interviews with managers. The availability of WFP, mostly eggs and chicken meat, was low; no other type of meat was available as WFP. Labeling was deficient, with little information about animal rearing systems. Labeling of regular products displaying images of happy animals was observed and may be a relevant confusing effect. Few certification seals for WFP were also observed, on organic products and free-range chickens. Welfare-friendly products costed 1.7 to 2.5 times more than regular products and great price variability was observed among retailers. Most retailers seemed not aware of the subject and considered that there is low availability of WFP to be offered in the markets. Low availability of WFP and poor label information of both regular and welfare-friendly products are barriers to better understand and meet the demand for higher welfare products. It is our perception that these are constraints for consumers to develop and perform ethical choices related to purchasing behavior.
DOI: 10.6084/m9.figshare.6318551.v1
title: Welfare-friendly Products: availability, labeling and opinion of retailers in Curitiba, Southern Brazil,

description: Abstract: The market for welfare-friendly products (WFP) is increasing worldwide; however, there is a lack of information on this topic in Brazil. We investigated availability, product information and opinion of retailers about WFP in Curitiba, Southern Brazil. We visited 36 strategically located retailers, conducting product evaluation and interviews with managers. The availability of WFP, mostly eggs and chicken meat, was low; no other type of meat was available as WFP. Labeling was deficient, with little information about animal rearing systems. Labeling of regular products displaying images of happy animals was observed and may be a relevant confusing effect. Few certification seals for WFP were also observed, on organic products and free-range chickens. Welfare-friendly products costed 1.7 to 2.5 times more than regular products and great price variability was observed among retailers. Most retailers seemed not aware of the subject and considered that there is low availability of WFP to be offered in the markets. Low availability of WFP and poor label information of both regular and welfare-friendly products are barriers to better understand and meet the demand for higher welfare products. It is our perception that these are constraints for consumers to develop and perform ethical choices related to purchasing behavior.
DOI: 10.6084/m9.figshare.6318548
title: Serum TSH level stability after 5 years in euthyroid adults at low risk for thyroid dysfunction

description: ABSTRACT Objective: To evaluate changes in thyroid function after 5 years, the interval proposed for new assessment, in initially euthyroid adults. Subjects and methods: Initially, 1,426 apparently healthy adults considered low risk for thyroid dysfunction, were evaluated by measurement of TSH. After 5 years, 1,215 (85.2%) subjects were reevaluated. Results: After 5 years, four subjects were receiving levothyroxine (L-T4) replacement therapy and 25 others had TSH &gt; 4 mIU/L, only two of them with TSH &gt; 10 mIU/L. All of these subjects had TSH &gt; 3 mIU/L in the initial evaluation. During reassessment, none of the subjects had been or was treated for hyperthyroidism and 22 had TSH &lt; 0.4 mIU/L (none of them &lt; 0.1 mIU/L). Nineteen of these subjects had TSH ≤ 0.6 mIU/L in the initial evaluation. Among the 1,098 subjects with TSH between 0.6 and 3 mIU/L in the initial evaluation, reassessment showed that none of the subjects was using L-T4; only three had TSH &gt; 4 mIU/L (none of them &gt; 10 mIU/L); none had been or was treated for hyperthyroidism, and only three had TSH &lt; 0.4 mIU/L (none of them &lt; 0.1 mIU/L). These results did not differ between men and women or between subjects ≤ 60 and &gt; 60 years. Conclusion: Repeat TSH measurement within an interval of only 5 years would not be cost-effective in adults without known thyroid disease or risk factors for dysfunction who exhibit TSH between 0.6 and 3 mIU/L.
DOI: 10.6084/m9.figshare.6318548.v1
title: Serum TSH level stability after 5 years in euthyroid adults at low risk for thyroid dysfunction

description: ABSTRACT Objective: To evaluate changes in thyroid function after 5 years, the interval proposed for new assessment, in initially euthyroid adults. Subjects and methods: Initially, 1,426 apparently healthy adults considered low risk for thyroid dysfunction, were evaluated by measurement of TSH. After 5 years, 1,215 (85.2%) subjects were reevaluated. Results: After 5 years, four subjects were receiving levothyroxine (L-T4) replacement therapy and 25 others had TSH &gt; 4 mIU/L, only two of them with TSH &gt; 10 mIU/L. All of these subjects had TSH &gt; 3 mIU/L in the initial evaluation. During reassessment, none of the subjects had been or was treated for hyperthyroidism and 22 had TSH &lt; 0.4 mIU/L (none of them &lt; 0.1 mIU/L). Nineteen of these subjects had TSH ≤ 0.6 mIU/L in the initial evaluation. Among the 1,098 subjects with TSH between 0.6 and 3 mIU/L in the initial evaluation, reassessment showed that none of the subjects was using L-T4; only three had TSH &gt; 4 mIU/L (none of them &gt; 10 mIU/L); none had been or was treated for hyperthyroidism, and only three had TSH &lt; 0.4 mIU/L (none of them &lt; 0.1 mIU/L). These results did not differ between men and women or between subjects ≤ 60 and &gt; 60 years. Conclusion: Repeat TSH measurement within an interval of only 5 years would not be cost-effective in adults without known thyroid disease or risk factors for dysfunction who exhibit TSH between 0.6 and 3 mIU/L.
DOI: 10.6084/m9.figshare.6318536
title: Optimización de polifenoles y aceptabilidad de caramelos de goma con extracto de jengibre (Zingiber officinale R.) y miel con diseño de mezclas

description: Resumen El objetivo de este trabajo fue optimizar el contenido de polifenoles totales, firmeza, dulzor y aceptabilidad general de caramelos de goma desarrollado con extracto de jengibre y seis proporciones de sacarosa, miel de abeja y glucosa. Para estudiar el efecto de las proporciones se utilizó el Diseño de Mezclas Simplex Lattice. El diseño fue repetido para cuatro niveles de extracto de jengibre: 25%, 41.7%, 58.3% y 75%. Los modelos cuadráticos fueron los que mejor describieron el comportamiento de cada variable estudiada (R2 &gt; 0.95), con los cuales se pudo determinar que las concentraciones de sacarosa, miel y glucosa que optimizan el contenido de polifenoles y aceptabilidad sensorial fueron 27.5%, 27.5% y 10%, respectivamente, con extracto de jengibre al 41.7%.
DOI: 10.6084/m9.figshare.6318536.v1
title: Optimización de polifenoles y aceptabilidad de caramelos de goma con extracto de jengibre (Zingiber officinale R.) y miel con diseño de mezclas

description: Resumen El objetivo de este trabajo fue optimizar el contenido de polifenoles totales, firmeza, dulzor y aceptabilidad general de caramelos de goma desarrollado con extracto de jengibre y seis proporciones de sacarosa, miel de abeja y glucosa. Para estudiar el efecto de las proporciones se utilizó el Diseño de Mezclas Simplex Lattice. El diseño fue repetido para cuatro niveles de extracto de jengibre: 25%, 41.7%, 58.3% y 75%. Los modelos cuadráticos fueron los que mejor describieron el comportamiento de cada variable estudiada (R2 &gt; 0.95), con los cuales se pudo determinar que las concentraciones de sacarosa, miel y glucosa que optimizan el contenido de polifenoles y aceptabilidad sensorial fueron 27.5%, 27.5% y 10%, respectivamente, con extracto de jengibre al 41.7%.
DOI: 10.6084/m9.figshare.6318533
title: Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma

description: ABSTRACT Objectives: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. Subjects and methods: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND). The results of SLNM were compared with CND pathological findings to verify the accuracy of sentinel SLNM. Results: The mean patients’ follow-up was 36 months. A total of 133 SLN were found at levels VI, II, III and IV. The SLN was identified in 95% of the patients with one false negative, 95% sensitivity, a 94% negative predictive value and 97% accuracy. The SLNM upstaging from cN0 to pN+ was 49%, and to stages III and IVa, it was 21%. Conclusions: For this series of cN0 PTC patients: 1) SLNM accuracy was 97%, and 2) SLNM upstaging from cN0 to pN+ was 49%, whereas to stages III and IVa, it was 21%.
DOI: 10.6084/m9.figshare.6318533.v1
title: Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma

description: ABSTRACT Objectives: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. Subjects and methods: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND). The results of SLNM were compared with CND pathological findings to verify the accuracy of sentinel SLNM. Results: The mean patients’ follow-up was 36 months. A total of 133 SLN were found at levels VI, II, III and IV. The SLN was identified in 95% of the patients with one false negative, 95% sensitivity, a 94% negative predictive value and 97% accuracy. The SLNM upstaging from cN0 to pN+ was 49%, and to stages III and IVa, it was 21%. Conclusions: For this series of cN0 PTC patients: 1) SLNM accuracy was 97%, and 2) SLNM upstaging from cN0 to pN+ was 49%, whereas to stages III and IVa, it was 21%.
DOI: 10.6084/m9.figshare.6318530
title: Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

description: ABSTRACT Objective: The aim of this study is to evaluate the influence of the body mass index (BMI) and the metabolic syndrome (MetS) parameters on oxidative and nitrosative stress in overweight and obese subjects. Subjects and methods: Individuals were divided into three groups: the control group (G1, n = 131) with a BMI between 20 and 24.9 kg/m2, the overweight group (G2, n = 120) with a BMI between 25 and 29.9 kg/m2 and the obese group (G3, n = 79) with a BMI ≥ 30 kg/m2. Results: G3 presented higher advanced oxidation protein products (AOPPs) in relation to G1 and G2 (p = 0.001 and p = 0.011, respectively) whereas G2 and G3 had lower levels of nitric oxide (NO) (p = 0.009 and p = 0.048, respectively) compared to G1. Adjusted for the presence of MetS to evaluate its influence, the levels of AOPPs did not differ between the groups, whereas NO remained significantly lower. Data adjusted by the BMI showed that subjects with higher triacylglycerol levels had higher AOPPs (p = 0.001) and decreased total radical-trapping antioxidant parameter/uric Acid (p = 0.036). Subjects with lower high-density lipoprotein (HDL) levels and patients with higher blood pressure showed increased AOPPs (p = 0.001 and p = 0.034, respectively) and lower NO levels (p = 0.017 and p = 0.043, respectively). Subjects who presented insulin resistance had higher AOPPs (p = 0.024). Conclusions: Nitrosative stress was related to BMI, and protein oxidation and nitrosative stress were related to metabolic changes and hypertension. MetS components were essential participants in oxidative and nitrosative stress in overweight and obese subjects.
DOI: 10.6084/m9.figshare.6318530.v1
title: Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

description: ABSTRACT Objective: The aim of this study is to evaluate the influence of the body mass index (BMI) and the metabolic syndrome (MetS) parameters on oxidative and nitrosative stress in overweight and obese subjects. Subjects and methods: Individuals were divided into three groups: the control group (G1, n = 131) with a BMI between 20 and 24.9 kg/m2, the overweight group (G2, n = 120) with a BMI between 25 and 29.9 kg/m2 and the obese group (G3, n = 79) with a BMI ≥ 30 kg/m2. Results: G3 presented higher advanced oxidation protein products (AOPPs) in relation to G1 and G2 (p = 0.001 and p = 0.011, respectively) whereas G2 and G3 had lower levels of nitric oxide (NO) (p = 0.009 and p = 0.048, respectively) compared to G1. Adjusted for the presence of MetS to evaluate its influence, the levels of AOPPs did not differ between the groups, whereas NO remained significantly lower. Data adjusted by the BMI showed that subjects with higher triacylglycerol levels had higher AOPPs (p = 0.001) and decreased total radical-trapping antioxidant parameter/uric Acid (p = 0.036). Subjects with lower high-density lipoprotein (HDL) levels and patients with higher blood pressure showed increased AOPPs (p = 0.001 and p = 0.034, respectively) and lower NO levels (p = 0.017 and p = 0.043, respectively). Subjects who presented insulin resistance had higher AOPPs (p = 0.024). Conclusions: Nitrosative stress was related to BMI, and protein oxidation and nitrosative stress were related to metabolic changes and hypertension. MetS components were essential participants in oxidative and nitrosative stress in overweight and obese subjects.
DOI: 10.6084/m9.figshare.6318527
title: Estimated costs of hospitalization due to coronary artery disease attributable to familial hypercholesterolemia in the Brazilian public health system

description: ABSTRACT Objective: Cardiovascular diseases are the leading cause of death in Brazil, imposing substantial economic burden on the health care system. Familial hypercholesterolemia (FH) is known to greatly increase the risk of premature coronary artery disease (CAD). This study aimed to estimate the economic impact of hospitalizations due to CAD attributable to FH in the Brazilian Unified Health Care System (SUS). Subjects and methods: Retrospective, cross-sectional study of data obtained from the Hospital Information System of the SUS (SIHSUS). We selected all adults (≥ 20 years of age) hospitalized from 2012-2014 with primary diagnoses related to CAD (ICD-10 I20 to I25). Attributable risk methodology estimated the contribution of FH in the outcomes of interest, using international data for prevalence (0.4% and 0.73%) and relative risk for events (RR = 8.56). Results: Assuming an international prevalence of FH of 0.4% and 0.73%, of the 245,981 CAD admissions/year in Brazil, approximately 7,249 and 12,915, respectively, would be attributable to an underlying diagnosis of FH. The total cost due to CAD per year, considering both sexes and all adults, was R$ 985,919,064, of which R$ 29,053,500 and R$ 51,764,175, respectively, were estimated to be attributable to FH. The average cost per FH-related CAD event was R$ 4,008. Conclusion: Based on estimated costs of hospitalization for CAD, we estimated that 2.9-5.3% are directed to FH patients. FH can require early specific therapies to lower risk in families. It is mandatory to determine the prevalence of FH and institute appropriate treatment to minimize the clinical and economic impact of this disease in Brazil.
DOI: 10.6084/m9.figshare.6318527.v1
title: Estimated costs of hospitalization due to coronary artery disease attributable to familial hypercholesterolemia in the Brazilian public health system

description: ABSTRACT Objective: Cardiovascular diseases are the leading cause of death in Brazil, imposing substantial economic burden on the health care system. Familial hypercholesterolemia (FH) is known to greatly increase the risk of premature coronary artery disease (CAD). This study aimed to estimate the economic impact of hospitalizations due to CAD attributable to FH in the Brazilian Unified Health Care System (SUS). Subjects and methods: Retrospective, cross-sectional study of data obtained from the Hospital Information System of the SUS (SIHSUS). We selected all adults (≥ 20 years of age) hospitalized from 2012-2014 with primary diagnoses related to CAD (ICD-10 I20 to I25). Attributable risk methodology estimated the contribution of FH in the outcomes of interest, using international data for prevalence (0.4% and 0.73%) and relative risk for events (RR = 8.56). Results: Assuming an international prevalence of FH of 0.4% and 0.73%, of the 245,981 CAD admissions/year in Brazil, approximately 7,249 and 12,915, respectively, would be attributable to an underlying diagnosis of FH. The total cost due to CAD per year, considering both sexes and all adults, was R$ 985,919,064, of which R$ 29,053,500 and R$ 51,764,175, respectively, were estimated to be attributable to FH. The average cost per FH-related CAD event was R$ 4,008. Conclusion: Based on estimated costs of hospitalization for CAD, we estimated that 2.9-5.3% are directed to FH patients. FH can require early specific therapies to lower risk in families. It is mandatory to determine the prevalence of FH and institute appropriate treatment to minimize the clinical and economic impact of this disease in Brazil.
DOI: 10.6084/m9.figshare.6318524
title: Waist circumference is an effect modifier of the association between bone mineral density and glucose metabolism

description: ABSTRACT Objective: The role of bone markers on insulin resistance (IR) remains controversial. The objective of this study is to evaluate the association between bone mineral density (BMD) and glucose metabolism and investigate if visceral hyperadiposity, evaluated by waist circumference (WC), is an effect modifier of this association. Subjects and methods: Cross-sectional analysis with 468 young adults from the fourth follow-up of the 1978/79 Ribeirão Preto prospective birth cohort, Brazil. BMD, total osteocalcin (OC), fasting plasma glucose and insulin concentrations were assessed. IR, sensitivity (S) and secretion (β) were estimated by homeostasis model assessment (HOMA) indexes. Multiple linear regression models were constructed to estimate the association between BMD and glucose metabolism. Beta coefficient, R2 and p-values were provided. WC was tested as an effect modifier and OC as a confounder. The covariates were selected based on Direct Acyclic Graph. Results: Significant interaction between BMD (femoral neck and proximal femur areas) and WC on glucose metabolism was observed in the adjusted models. Subjects with increased WC presented a positive association between BMD and log HOMA1-IR while an inverse association was found in those with normal WC (femoral neck R2 = 0.17, p = 0.036; proximal femur R2 = 0.16, p = 0.086). BMD was negatively associated with log HOMA2-S in individuals with increased WC and positively in those with normal WC (femoral neck R2 = 0.16, p = 0.042; proximal femur R2 = 0.15, p = 0.097). No significant associations between BMD, log HOMA2-β and OC and glucose metabolism markers were observed. Conclusions: BMD was associated with glucose metabolism, independently of OC, and WC modifies this association.