cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34943/3480b9d5-cbde-4c58-bba9-9d8c1f8ac0ba
title: Folger Pinnacle Fluorometer Turbidity Deployed 2022-04-07

description: The WET Labs ECO FLNTUS 895 was deployed on 2022-04-07 at Folger Pinnacle. Folger Pinnacle is an isolated pillar-like feature in Folger Passage, where biodiversity and coastal ecosystems are observed. This device is a Fluorometer Turbidity. Fluorometer Turbidity instruments measure chlorophyll fluorescence and turbidity within the same volume of seawater. The instrument uses a light emitting diode (LED) to provide an excitation source. The fluoresced light is received by a detector at a particular angle from the LED source, and uses an interference filter to discriminate against scattered excitation light. Turbidity is measured at the same time, by detecting scattered light from a LED, which is positioned at the same angle as the chlorophyll fluorescence. It was deployed on a fixed platform. Data from this deployment were archived and made available through Ocean Networks Canada's Oceans 3.0 digital infrastructure, with quality assurance and derived data products following established practices.
DOI: 10.21227/19qb-9t12
title: Gas Sensor Demo

description: In the present work, Prosopis Juliflora, an invasive alien plant species, is processed and converted into a useful biomass carbon material. For gas sensing application, SnO2 nanoparticles are anchored on the Prosopis Juliflora biomass carbon leaves (BML) using a sol-gel process. The BML/SnO2 nanocomposite is fabricated and tested for hazardous NO2 gas sensing applications. The biomass carbon support and uniform distribution of SnO2 nanoparticles enabled the adsorption/desorption of target gas on the surface of the nanocomposite. The BML/SnO2 nanocomposite is assessed against highly toxic NO2 gas for varying concentrations and shows the maximum sensitivity of 31% for 90 ppm of the target gas. The overall gas sensing mechanism and significance of biomass carbon material is discussed in detail. In precise, the invasive species Prosopis juliflora is converted into useful biomass carbon and it is shown as one of the sustainable and alternative carbon support materials by successfully demonstrate the same as real time NO2 gas leak detecting system.
DOI: 10.6084/m9.figshare.14891499.v4
title: Applying Habitat Suitability Modelling to identify the distribution of a long distance avian migrant, the white stork, in the eastern sahelian.

description: Using monthly SDMs, the current <i>potential </i>and <i>realized</i> distribution of the white stork is analysed and hypothesis of future changes in its distribution are presented. Therefore, remotely sensed data is acquired and processed. Telemetry data is obtained from the <i>Movebank</i>-database and environmental data is obtained from various sources (e.g., from the <i>WorldClim</i>-database). Using telemetry data enables modelling the white stork distribution on the individual and on the population level. The models are based on the maximum entropy algorithm Maxent and limited to the wintering grounds of the white stork in Africa, which are located in the eastern Sahelian zone.Using monthly SDMs, the current <i>potential </i>and <i>realized</i> distribution of the white stork is analysed and hypothesis of future changes in its distribution are presented. Therefore, remotely sensed data is acquired and processed. Telemetry data is obtained from the <i>Movebank</i>-database and environmental data is obtained from various sources (e.g., from the <i>WorldClim</i>-database). Using telemetry data enables modelling the white stork distribution on the individual and on the population level. The models are based on the maximum entropy algorithm Maxent and limited to the wintering grounds of the white stork in Africa, which are located in the eastern Sahelian zone.
DOI: 10.34943/521c44b2-45ec-4af7-81d7-deeb8d47f748
title: Folger Pinnacle Radiometer Deployed 2022-04-07

description: The Biospherical PAR Irradiance QSP-2350L 70433 was deployed on 2022-04-07 at Folger Pinnacle. Folger Pinnacle is an isolated pillar-like feature in Folger Passage, where biodiversity and coastal ecosystems are observed. This device is a Radiometer. Radiometers collect measurements of electromagnetic radiation in the ocean environment. It was deployed on a fixed platform. Data from this deployment were archived and made available through Ocean Networks Canada's Oceans 3.0 digital infrastructure, with quality assurance and derived data products following established practices.
DOI: 10.34943/3f212a6a-f3a0-4eba-8d4d-4318ee38e051
title: Folger Pinnacle Conductivity Temperature Depth Deployed 2022-04-07

description: The Sea-Bird SeaCAT SBE19plus V2 7770 was deployed on 2022-04-07 at Folger Pinnacle. Folger Pinnacle is an isolated pillar-like feature in Folger Passage, where biodiversity and coastal ecosystems are observed. This device is a Conductivity Temperature Depth. Conductivity Temperature Depth (CTD) is an instrument package that contains sensors for measuring the conductivity, temperature, and pressure of seawater. Salinity, sound velocity, depth and density are variables that can be derived from sensor measurements. CTDs can carry additional instruments and sensors such as oxygen sensors, turbidity sensors and fluorometers. It was deployed on a fixed platform. Data from this deployment were archived and made available through Ocean Networks Canada's Oceans 3.0 digital infrastructure, with quality assurance and derived data products following established practices.
DOI: 10.34943/ee0128bf-e636-4595-92ea-1d21615c5ef3
title: Folger Pinnacle Oxygen Sensor Deployed 2022-04-07

description: The Sea-Bird SBE 63 Dissolved Oxygen Sensor 631533 was deployed on 2022-04-07 at Folger Pinnacle. Folger Pinnacle is an isolated pillar-like feature in Folger Passage, where biodiversity and coastal ecosystems are observed. This device is a Oxygen Sensor. Oxygen sensors measure dissolved oxygen concentration in seawater. It was deployed on a fixed platform. Data from this deployment were archived and made available through Ocean Networks Canada's Oceans 3.0 digital infrastructure, with quality assurance and derived data products following established practices.
DOI: 10.6084/m9.figshare.14891499.v5
title: Applying Habitat Suitability Modelling to identify the distribution of a long distance avian migrant, the white stork, in the eastern sahelian.

description: Using monthly SDMs, the current <em>potential </em>and <em>realized</em> distribution of the white stork is analysed and hypothesis of future changes in its distribution are presented. Therefore, remotely sensed data is acquired and processed. Telemetry data is obtained from the <em>Movebank</em>-database and environmental data is obtained from various sources (e.g., from the <em>WorldClim</em>-database). Using telemetry data enables modelling the white stork distribution under current and future climatic conditions. The models are based on the machine learning algorithm Maxent and limited to the wintering grounds of the white stork in Africa, which are located in the eastern Sahelian zone. As a data source, remotely sensed data , as well as telemetry data is used.
DOI: 10.5281/zenodo.6427057
title: LLoguer d'habitatges vallès occidental

description: Dataset de les dades recollides a la web habitaclia.com, on es recull les principals característiques dels habitatges que s'oferten per lloguer
DOI: 10.5281/zenodo.6427056
title: LLoguer d'habitatges vallès occidental

description: Dataset de les dades recollides a la web habitaclia.com, on es recull les principals característiques dels habitatges que s'oferten per lloguer
DOI: 10.34740/kaggle/dsv/2847189
title: Australian Football League (AFL) Database
DOI: 10.5281/zenodo.6427111
title: Arthrogenic Muscle Inhibition - decomposed EMG

description: ACL-injured and healthy controls performed isometric contractions (10-50% maximal voluntary contractions) while EMG was being measured of the quadriceps and hamstrings. The EMG was decomposed to individual motor unit characteristics.
description: {"references": ["https://doi.org/10.1080/17461391.2022.2056520"]}
DOI: 10.6084/m9.figshare.19560112
title: main.m

description: The main function
DOI: 10.6084/m9.figshare.19560112.v1
title: main.m

description: The main function
DOI: 10.5281/zenodo.6420633
title: Raw RNAseq count data for figure 4 - by Van de Beek et al., 2022

description: This CSV file is generated by Van de Beek et al., (2022) and is part of "<strong><em>PRDM10</em></strong><strong> directs <em>FLCN</em> expression in a novel disorder overlapping with Birt-Hogg-Dubé syndrome and familial lipomatosis</strong>" to be published in Human Molecular Genetics.
DOI: 10.34740/kaggle/dsv/3432048
title: YouTube Trending Video Dataset (updated daily)
DOI: 10.6084/m9.figshare.19560238
title: Duodenal adenocarcinoma

description: Data collection from tree hospital for the study
DOI: 10.6084/m9.figshare.19560238.v1
title: Duodenal adenocarcinoma

description: Data collection from tree hospital for the study
DOI: 10.34740/kaggle/dsv/3432077
title: 2021 World Population (updated daily)
DOI: 10.6084/m9.figshare.6116315
title: Low dose-rate irradiation with [<sup>3</sup>H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model

description: Earlier <i>in vitro</i> studies show that irradiation with an ultra-low dose-rate of 15 mGy/h delivered with [<sup>3</sup>H]-valine leads to loss of clonogenicity in hypoxic T-47D cells. Here, the aim was to determine if [<sup>3</sup>H]-valine could be used to deliver low dose-rate irradiation in a colorectal cancer model. Clonogenicity was measured in cultured cancer cell line HT29 irradiated with 15 mGy/h combined with intermittent hypoxia. Mice with HT29 xenografts were irradiated by repeated injections of [<sup>3</sup>H]-valine intravenously. The activity in the tumor tissue was measured by scintillation counting and tumor growth, hypoxic fraction and tritium distribution within tumors were assessed by pimonidazole staining and autoradiography. Ultra-low dose-rate irradiation decreased clonogenicity in hypoxic colorectal cancer cells. <i>In vivo</i>, the tumor growth, hypoxic fraction and weight of the mice were similar between the treated and untreated group. Autoradiography showed no [<sup>3</sup>H]-valine uptake in hypoxic tumor regions in contrast to aerobic tissue. Continuous low-dose-rate irradiation was well tolerated by aerobic tissue. This indicates a potential use of low dose-rate irradiation to target hypoxic tumor cells in combination with high dose-rate irradiation to eradicate the well oxygenated tumor regions. However, [<sup>3</sup>H]-valine is not the appropriate method to deliver ultra-low dose-rate irradiation <i>in vivo</i>.
DOI: 10.6084/m9.figshare.6171617
title: Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab

description: The introduction of immune check-point inhibition in non-small cell lung cancer (NSCLC) therapy represents improved prospects for the patients. The response rates to check-point inhibitors are approximately 20% in unselected NSCLC patients. Increasing levels of tumor PD-L1 expression are associated with higher response rates. However, patients with low PD-L1 levels may also have durable responses, and improved strategies for patient stratification are needed. In this study, we investigated circulating microRNAs aiming to identify circulating predictive biomarkers associated with increased overall survival after immune check-point treatment. Using next generation sequencing, we performed microRNA profiling in serum from NSCLC patients (<i>n</i> = 20) treated with nivolumab. Serum samples from 31 patients were used for validation using qPCR assays. Serum samples were collected prior to immune therapy initiation. Based on multivariate regression analysis, we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival (OS) &gt; 6 months in discovery cohort (<i>p</i> = .0003). We further validated this in another similar set of samples (<i>n</i> = 31) and the model was significantly associated with overall survival (OS) &gt; 6 months (<i>p</i> = .001) with sensitivity and specificity of 71% and 90%, respectively. In this study of circulating microRNAs, we have identified a 7-miR signature associated with survival in nivolumab-treated NSCLC patients. This signature may lead to better treatment options for patients with NSCLC, but a validation in an independent cohort is needed to confirm the predicted potential.
DOI: 10.6084/m9.figshare.6116315.v2
title: Low dose-rate irradiation with [<sup>3</sup>H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model

description: Earlier <i>in vitro</i> studies show that irradiation with an ultra-low dose-rate of 15 mGy/h delivered with [<sup>3</sup>H]-valine leads to loss of clonogenicity in hypoxic T-47D cells. Here, the aim was to determine if [<sup>3</sup>H]-valine could be used to deliver low dose-rate irradiation in a colorectal cancer model. Clonogenicity was measured in cultured cancer cell line HT29 irradiated with 15 mGy/h combined with intermittent hypoxia. Mice with HT29 xenografts were irradiated by repeated injections of [<sup>3</sup>H]-valine intravenously. The activity in the tumor tissue was measured by scintillation counting and tumor growth, hypoxic fraction and tritium distribution within tumors were assessed by pimonidazole staining and autoradiography. Ultra-low dose-rate irradiation decreased clonogenicity in hypoxic colorectal cancer cells. <i>In vivo</i>, the tumor growth, hypoxic fraction and weight of the mice were similar between the treated and untreated group. Autoradiography showed no [<sup>3</sup>H]-valine uptake in hypoxic tumor regions in contrast to aerobic tissue. Continuous low-dose-rate irradiation was well tolerated by aerobic tissue. This indicates a potential use of low dose-rate irradiation to target hypoxic tumor cells in combination with high dose-rate irradiation to eradicate the well oxygenated tumor regions. However, [<sup>3</sup>H]-valine is not the appropriate method to deliver ultra-low dose-rate irradiation <i>in vivo</i>.
DOI: 10.6084/m9.figshare.5891929.v2
title: Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014

description: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014. All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence. About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980–1984 to 62.4% in 2010–2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival. This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.
DOI: 10.6084/m9.figshare.6171617.v2
title: Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab

description: The introduction of immune check-point inhibition in non-small cell lung cancer (NSCLC) therapy represents improved prospects for the patients. The response rates to check-point inhibitors are approximately 20% in unselected NSCLC patients. Increasing levels of tumor PD-L1 expression are associated with higher response rates. However, patients with low PD-L1 levels may also have durable responses, and improved strategies for patient stratification are needed. In this study, we investigated circulating microRNAs aiming to identify circulating predictive biomarkers associated with increased overall survival after immune check-point treatment. Using next generation sequencing, we performed microRNA profiling in serum from NSCLC patients (<i>n</i> = 20) treated with nivolumab. Serum samples from 31 patients were used for validation using qPCR assays. Serum samples were collected prior to immune therapy initiation. Based on multivariate regression analysis, we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival (OS) &gt; 6 months in discovery cohort (<i>p</i> = .0003). We further validated this in another similar set of samples (<i>n</i> = 31) and the model was significantly associated with overall survival (OS) &gt; 6 months (<i>p</i> = .001) with sensitivity and specificity of 71% and 90%, respectively. In this study of circulating microRNAs, we have identified a 7-miR signature associated with survival in nivolumab-treated NSCLC patients. This signature may lead to better treatment options for patients with NSCLC, but a validation in an independent cohort is needed to confirm the predicted potential.
DOI: 10.6084/m9.figshare.6189620
title: Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)

description: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy<sup>®</sup>, proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. A multicenter (<i>n</i> = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy<sup>®</sup>, PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36.0/1.8 Gy). Different treatment plans were optimized based on the same planning target volume margin. All participating institutes returned their best treatment plan applicable in clinic. The modern radiotherapy techniques investigated resulted in superior conformity/homogeneity-indices (CI/HI), particularly in the spinal part of the target (CI: 3D-CRT:0.3 vs. modern:0.6; HI: 3D-CRT:0.2 vs. modern:0.1), and demonstrated a decreased dose to the thyroid, heart, esophagus and pancreas. Dose reductions of &gt;10.0 Gy were observed with PBS compared to modern photon techniques for parotid glands, thyroid and pancreas. Following this technique, a wide range in dosimetry among centers using the same technique was observed (e.g., thyroid mean dose: VMAT: 5.6–24.6 Gy; PBS: 0.3–10.1 Gy). The investigated modern radiotherapy techniques demonstrate superior dosimetric results compared to 3D-CRT. The lowest mean dose for organs at risk is obtained with proton therapy. However, for a large number of organs ranges in mean doses were wide and overlapping between techniques making it difficult to recommend one radiotherapy technique over another.
DOI: 10.6084/m9.figshare.6293384
title: DW-MRI and DCE-MRI are of complementary value in predicting pathologic response to neoadjuvant chemoradiotherapy for esophageal cancer

description: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2–3) (per) and after completion of nCRT, but prior to esophagectomy (post). Subsequently, histopathologic tumor regression grade (TRG) was assessed. Tumor apparent diffusion coefficient (ADC) and area-under-the-concentration time curve (AUC) were calculated for DW-MRI and DCE-MRI, respectively. The ability of these parameters to predict pathologic complete response (pCR, TRG1) or good response (GR, TRG ≤ 2) to nCRT was assessed. Furthermore the complementary value of DW-MRI and DCE-MRI was investigated. GR was found in 22 (49%) patients, of which 10 (22%) patients showed pCR. For DW-MRI, the 75th percentile (P75) ΔADC<sub>post-pre</sub> was most predictive for GR (c-index = 0.75). For DCE-MRI, P90 ΔAUC<sub>per-pre</sub> was most predictive for pCR (c-index = 0.79). Multivariable logistic regression analyses showed complementary value when combining DW-MRI and DCE-MRI for pCR prediction (c-index = 0.89). Both DW-MRI and DCE-MRI are promising in predicting response to nCRT in esophageal cancer. Combining both modalities provides complementary information, resulting in a higher predictive value.
DOI: 10.6084/m9.figshare.6116315.v1
title: Low dose-rate irradiation with [<sup>3</sup>H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model

description: <b>Background:</b> Earlier <i>in vitro</i> studies show that irradiation with an ultra-low dose-rate of 15 mGy/h delivered with [<sup>3</sup>H]-valine leads to loss of clonogenicity in hypoxic T-47D cells. Here, the aim was to determine if [<sup>3</sup>H]-valine could be used to deliver low dose-rate irradiation in a colorectal cancer model. <b>Methods:</b> Clonogenicity was measured in cultured cancer cell line HT29 irradiated with 15 mGy/h combined with intermittent hypoxia. Mice with HT29 xenografts were irradiated by repeated injections of [<sup>3</sup>H]-valine intravenously. The activity in the tumor tissue was measured by scintillation counting and tumor growth, hypoxic fraction and tritium distribution within tumors were assessed by pimonidazole staining and autoradiography. <b>Results:</b> Ultra-low dose-rate irradiation decreased clonogenicity in hypoxic colorectal cancer cells. <i>In vivo</i>, the tumor growth, hypoxic fraction and weight of the mice were similar between the treated and untreated group. Autoradiography showed no [<sup>3</sup>H]-valine uptake in hypoxic tumor regions in contrast to aerobic tissue. <b>Conclusion:</b> Continuous low-dose-rate irradiation was well tolerated by aerobic tissue. This indicates a potential use of low dose-rate irradiation to target hypoxic tumor cells in combination with high dose-rate irradiation to eradicate the well oxygenated tumor regions. However, [<sup>3</sup>H]-valine is not the appropriate method to deliver ultra-low dose-rate irradiation <i>in vivo</i>.