cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24516808.v1
title: Supplementary Material for: Association between Obesity and periodontitis in US Adults: NHANES 2011–2014

description: Introduction: It is controversial whether obesity and periodontitis are related. A representative U.S. population was examined for the relationship between obesity and periodontitis. Methods: In the National Health and Nutrition Examination Survey (NHANES) 2011-2014, participants (n = 6662)aged 30 or older and underwent periodontal examinations were chosen for analysis. An assessment of obesity was based on body mass index (BMI) and waist circumference (WC). Estimates of obesity and periodontal disease were made using univariate and multivariate logistic regression models. Results: According to an adjusted odds ratio (OR) for periodontitis,BMI (OR=1.01, 95%CI: 1.01~1.02) and WC (OR=1.01, 95%CI: 1~1.01) were significantly associated with periodontitis, respectively. After adjusting for confounding factors, the OR for patients with high WC with periodontitis was 1.18 (1.04~1.33) compared to normal WC. BMI and WC subgroups showed no significant interaction (P for interaction &gt; 0.05), except for the age interaction in BMI. Among young adults aged 30 to 44, obesity was significantly associated with periodontitis in subgroups, the adjusted OR for having periodontal disease were 1.02 (1~1.03) and 1.01 (1~1.02) for subjects with BMI, and WC, respectively. When all covariates were adjusted, BMI ≥ 30 kg/m2 was statistically significantly associated with prevalence of periodontal disease among people aged 30 to 44 (P &lt;0.001). Conclusions: BMI and WC are significantly associated with periodontitis, even after adjusting for many variables, and were equally significant in obese (BMI≥30 kg/m2 ) young people (30 to 44 years).
DOI: 10.25345/c5j960m6t
title: MassIVE MSV000093549 - Organische componenten in water (20 bronnen) +
title: Organische componenten in water (20 bronnen) + Organische componenten in water (20 bronnen) + Organische componenten in water (20 bronnen) +
DOI: 10.6084/m9.figshare.24551560
title: Supplementary Material for: Assessment of Internet Available Patient Information on Chronic Pancreatitis Using the Ensuring Quality Information for Patients Tool: A Systematic Search and Evaluation

description: Introduction: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known. Methods: A systematic review of the information about CP available online using the search term “chronic pancreatitis” in using the search engine Google has been conducted. The quality of the top 100 websites returned from this search term were analysed using the validated Ensuring Quality Information for Patients (EQIP) tool (maximum score 36). Additional items were included in the website analysis specific to CP. Results: In total, 45 websites were eligible for analysis. The median EQIP score of the websites was 16 (IQR 12-19.5). The majority of websites originated from the United States and the United Kingdom with 31 and 11 websites, respectively. Provision of additional information was inconsistent, with most websites covering information regarding aetiology and advocating alcohol and tobacco cessation, but only few reporting on more complex issues. Conclusion: Internet available information about CP is of limited quality. There is an immediate need for high quality, patient targeted and informative literature accessible on the internet about this topic.
DOI: 10.6084/m9.figshare.24189993
title: Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity

description: E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promoting epithelial cell adhesion, but the mechanism remains unknown. We show that Scribble, Lgl1, and NMII-A reside in a complex with E-cadherin-catenin complex. Depletion of either Scribble or Lgl1 disrupts the localization of E-cadherin-catenin complex to AJs. aPKCζ phosphorylation of Lgl1 regulates AJ localization of Lgl1 and E-cadherin-catenin complexes. Both Scribble and Lgl1 regulate the activation and recruitment of NMII-A at AJs. Finally, Scribble and Lgl1 are downregulated by TGFβ-induced EMT, and their re-expression during EMT impedes its progression. Our results provide insight into the mechanism regulating AJ integrity by Scribble, Lgl1, and NMII-A.
DOI: 10.6084/m9.figshare.24189993.v1
title: Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity

description: E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promoting epithelial cell adhesion, but the mechanism remains unknown. We show that Scribble, Lgl1, and NMII-A reside in a complex with E-cadherin-catenin complex. Depletion of either Scribble or Lgl1 disrupts the localization of E-cadherin-catenin complex to AJs. aPKCζ phosphorylation of Lgl1 regulates AJ localization of Lgl1 and E-cadherin-catenin complexes. Both Scribble and Lgl1 regulate the activation and recruitment of NMII-A at AJs. Finally, Scribble and Lgl1 are downregulated by TGFβ-induced EMT, and their re-expression during EMT impedes its progression. Our results provide insight into the mechanism regulating AJ integrity by Scribble, Lgl1, and NMII-A.
DOI: 10.5281/zenodo.10245855
title: Invasive earthworms can change understory plant community traits and reduce plant functional diversity

description: Datasets and R script
description: Among the most important impacts of biological invasions on biodiversity is biotic homogenization, which may further compromise key ecosystem processes. However, the extent to which they homogenize functional diversity and shift dominant ecological strategies of invaded communities remains uncertain. Here, we investigated changes in plant communities in a northern North American forest in response to invasive earthworms, by examining the taxonomic and functional diversity of the plant community and soil ecosystem functions. We found that although plant taxonomic diversity did not change in response to invasive earthworms, they modified the dominance structure of plant functional groups. Invasive earthworms promoted the dominance of fast-growing plants at the expense of slow-growing ones. Moreover, earthworms decreased plant functional diversity, which coincided with changes in abiotic and biotic soil properties. Our study reveals that invasive earthworms erode multiple biodiversity facets of invaded forests, with potential cascading effects on ecosystem functioning.
DOI: 10.5281/zenodo.10245856
title: Invasive earthworms can change understory plant community traits and reduce plant functional diversity

description: Datasets and R script
description: Among the most important impacts of biological invasions on biodiversity is biotic homogenization, which may further compromise key ecosystem processes. However, the extent to which they homogenize functional diversity and shift dominant ecological strategies of invaded communities remains uncertain. Here, we investigated changes in plant communities in a northern North American forest in response to invasive earthworms, by examining the taxonomic and functional diversity of the plant community and soil ecosystem functions. We found that although plant taxonomic diversity did not change in response to invasive earthworms, they modified the dominance structure of plant functional groups. Invasive earthworms promoted the dominance of fast-growing plants at the expense of slow-growing ones. Moreover, earthworms decreased plant functional diversity, which coincided with changes in abiotic and biotic soil properties. Our study reveals that invasive earthworms erode multiple biodiversity facets of invaded forests, with potential cascading effects on ecosystem functioning.
DOI: 10.6084/m9.figshare.24637815.v1
title: Supplementary Material for: Persistent Hydrocephalus, Shunt and Subglottic Stenosis in a Newborn with Plasminogen Deficiency due to Delayed Treatment with Plasminogen Concentrates - a case report

description: Here we present the case of a newborn baby boy with severe plasminogen deficiency (PD) causing occlusive hydrocephalus and ligneous conjunctivitis. Shortly after birth, the hydrocephalus was treated with a ventriculo-peritoneal (VP) shunt implantation. However, the child had to be readmitted soon afterwards because of shunt obstruction. Tracheal microtrauma caused by the necessary intubations, then led to another life-threatening complication - subglottic pseudomembrane formation and obstruction. Microsurgical removal had to be performed to secure the airway. Initially, regular plasma transfusions achieved slightly elevated plasminogen activity levels and short-term improvement of the respiratory situation. However, shunt dysfunction reoccurred, and alternative treatment options were needed. . Since therapy with plasminogen concentrate is already available in the USA with encouraging results, this treatment option was organized in hopes of equally good results for this patient. Fortunately, under short term substitution with plasminogen concentrates, the implantation of a new VP shunt was successful and respiratory problems resolved. Plasminogen concentrates are critically needed in Europe and other parts of the world to improve the care of and prevent complications among patients with plasminogen deficiency.
DOI: 10.34945/f5jc70
title: PI3K inhibition in foamy macrophages after T8 spinal cord contusion in female mice, and in cultured macrophages treated with spinal cord homogenate

description: STUDY PURPOSE: Inflammation after spinal cord injury (SCI) creates a cellular environment adverse to neural regeneration. Macrophages are one of the major classes of inflammatory immune cells at the injury site, and a subset of these cells with pro-inflammatory function are “foamy” macrophages. These cells become lipid-laden due to excessive lipid uptake of myelin and cellular debris after injury and add to the harmful inflammatory milieu of the SCI wound. In this study, we investigated the cellular and molecular mechanisms by which foamy macrophages may drive the cellular pathology after subacute SCI (7 days post injury). DATA COLLECTED: We developed a novel in vitro assay to model foamy macrophages formation after SCI using primary bone-marrow derived macrophages treated with wildtype spinal cord homogenate to represent virtually all the lipid sources present after SCI. In vitro analysis of foamy macrophages included protein blotting, RNA sequencing, Seahorse metabolic profiling, reactive oxygen species dye, qPCR analysis and immunocytochemistry. For in vivo experiments, 8-10-week-old female mice received mid-thoracic contusive SCI and were treated with Torin-2 filled liposomes at 1, 3, and 6 days post injury (dpi) and tissue analyzed at 7 dpi with immunohistochemistry. DATA USAGE NOTES:
DOI: 10.6084/m9.figshare.24637815
title: Supplementary Material for: Persistent Hydrocephalus, Shunt and Subglottic Stenosis in a Newborn with Plasminogen Deficiency due to Delayed Treatment with Plasminogen Concentrates - a case report

description: Here we present the case of a newborn baby boy with severe plasminogen deficiency (PD) causing occlusive hydrocephalus and ligneous conjunctivitis. Shortly after birth, the hydrocephalus was treated with a ventriculo-peritoneal (VP) shunt implantation. However, the child had to be readmitted soon afterwards because of shunt obstruction. Tracheal microtrauma caused by the necessary intubations, then led to another life-threatening complication - subglottic pseudomembrane formation and obstruction. Microsurgical removal had to be performed to secure the airway. Initially, regular plasma transfusions achieved slightly elevated plasminogen activity levels and short-term improvement of the respiratory situation. However, shunt dysfunction reoccurred, and alternative treatment options were needed. . Since therapy with plasminogen concentrate is already available in the USA with encouraging results, this treatment option was organized in hopes of equally good results for this patient. Fortunately, under short term substitution with plasminogen concentrates, the implantation of a new VP shunt was successful and respiratory problems resolved. Plasminogen concentrates are critically needed in Europe and other parts of the world to improve the care of and prevent complications among patients with plasminogen deficiency.
DOI: 10.6084/m9.figshare.24637911
title: Supplementary Material for: The Use of Authorized Concealment to Minimize Nocebo Side Effects: A Survey of U.S. Public Attitudes

description: Introduction: To minimize nocebo effects, it may be possible to employ authorized concealment, in which clinicians tell patients about the nocebo phenomenon and ask if they would prefer not to be informed about mild treatment side effects. Objective: To understand public evaluations of authorized concealment for reducing nocebo effects. Methods: An online cross-sectional survey was completed by a demographically diverse US national community sample between June 2-6, 2023. Participants were 1012 adults residing in 48 states, ages ranging from 18-94 (M=43.2), 65.4% regularly taking medication, and 66.6% reporting a chronic physical or mental health condition. After learning about nocebo effects, participants rated and estimated their likelihood of consenting to four potential methods for authorized concealment of mild side effects. The four methods were ranked for preference and ranked again with the options of (a) receiving all side-effect information and (b) having the opportunity to select among disclosure methods. Results: A majority of participants (86.2%) positively endorsed at least one authorized concealment method and 88.2% estimated they would consent to at least one method. Authorized concealment in which individuals learned only the most common side effects or had side-effect information available online received more positive ratings and rankings. A final ranking yielded preferences for receiving all side-effect information (30.4%) and having the opportunity to select side-effect disclosure method (31.8%). Conclusions: Our study suggests that many in the public could be open to authorized concealment for mild side effects when it is explained in reference to nocebo effects.
DOI: 10.6084/m9.figshare.24637911.v1
title: Supplementary Material for: The Use of Authorized Concealment to Minimize Nocebo Side Effects: A Survey of U.S. Public Attitudes

description: Introduction: To minimize nocebo effects, it may be possible to employ authorized concealment, in which clinicians tell patients about the nocebo phenomenon and ask if they would prefer not to be informed about mild treatment side effects. Objective: To understand public evaluations of authorized concealment for reducing nocebo effects. Methods: An online cross-sectional survey was completed by a demographically diverse US national community sample between June 2-6, 2023. Participants were 1012 adults residing in 48 states, ages ranging from 18-94 (M=43.2), 65.4% regularly taking medication, and 66.6% reporting a chronic physical or mental health condition. After learning about nocebo effects, participants rated and estimated their likelihood of consenting to four potential methods for authorized concealment of mild side effects. The four methods were ranked for preference and ranked again with the options of (a) receiving all side-effect information and (b) having the opportunity to select among disclosure methods. Results: A majority of participants (86.2%) positively endorsed at least one authorized concealment method and 88.2% estimated they would consent to at least one method. Authorized concealment in which individuals learned only the most common side effects or had side-effect information available online received more positive ratings and rankings. A final ranking yielded preferences for receiving all side-effect information (30.4%) and having the opportunity to select side-effect disclosure method (31.8%). Conclusions: Our study suggests that many in the public could be open to authorized concealment for mild side effects when it is explained in reference to nocebo effects.
DOI: 10.5258/soton/d2762
title: Bibliography in support of the Doctoral Thesis "In pursuit of stability in the New Europe: Czechoslovak and Yugoslav constitutional questions in British political discourse, 1918-1939"

description: This dataset supports a University of Southampton Doctoral Thesis "In pursuit of stability in the New Europe: Czechoslovak and Yugoslav constitutional questions in British political discourse, 1918-1939". The dataset contains a copy of my bibliography. It was collected throughout my research, by consulting books from the University of Southampton Library, UCL SSEES library, the British library, the documents held by the National Archives, UCL SSEES archives and the Imperial War Museum archives, as well as other online resources. The data is presented in Excel file. Related projects/Funders: This PhD was funded by the Wolfson Foundation.
DOI: 10.6084/m9.figshare.24658491
title: Supplementary Material for: Total hydrocortisone dosage in the neonatal period may be related to low developmental quotient in extremely low birth weight infants: a retrospective cohort study

description: Introduction: The effects of Hydrocortisone (HDC) administration to extremely low birthweight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental outcomes in ELBW infants. Methods: This study was a retrospective cohort study conducted in eight centers in Japan. The subjects of this study were ELBW infants born between April 2015 and March 2017. The association between postnatal total HDC dosage up to 36 weeks postmenstrual age and the developmental quotient (DQ) at 3 years of age was examined. Multiple linear regression evaluated the association adjusting for weeks of gestation, birth weight, and the presence of bronchopulmonary dysplasia, late-onset circulatory collapse, intracranial hemorrhage, necrotizing enterocolitis, and sepsis. Results : This study included 218 ELBW infants, of whom 144 underwent a developmental test at 3 years of age. Simple linear regression analysis revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: −2.65, 95% CI:−3.73, −1.57). Multiple linear regression analysis adjusted for the presence of bronchopulmonary dysplasia and late-onset circulatory collapse also revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: −2.66, 95% CI: −3.89, −1.42). Discussion/Conclusion: Higher total HDC dosage up to 36 weeks postmenstrual age in ELBW infants was associated with impaired neurodevelopmental outcomes. Although hydrocortisone is often needed in the treatment of ELBW infants, clinicians should be aware that an increased dose of hydrocortisone may be associated with impaired neurodevelopmental outcomes.
DOI: 10.6084/m9.figshare.24658491.v1
title: Supplementary Material for: Total hydrocortisone dosage in the neonatal period may be related to low developmental quotient in extremely low birth weight infants: a retrospective cohort study

description: Introduction: The effects of Hydrocortisone (HDC) administration to extremely low birthweight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental outcomes in ELBW infants. Methods: This study was a retrospective cohort study conducted in eight centers in Japan. The subjects of this study were ELBW infants born between April 2015 and March 2017. The association between postnatal total HDC dosage up to 36 weeks postmenstrual age and the developmental quotient (DQ) at 3 years of age was examined. Multiple linear regression evaluated the association adjusting for weeks of gestation, birth weight, and the presence of bronchopulmonary dysplasia, late-onset circulatory collapse, intracranial hemorrhage, necrotizing enterocolitis, and sepsis. Results : This study included 218 ELBW infants, of whom 144 underwent a developmental test at 3 years of age. Simple linear regression analysis revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: −2.65, 95% CI:−3.73, −1.57). Multiple linear regression analysis adjusted for the presence of bronchopulmonary dysplasia and late-onset circulatory collapse also revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: −2.66, 95% CI: −3.89, −1.42). Discussion/Conclusion: Higher total HDC dosage up to 36 weeks postmenstrual age in ELBW infants was associated with impaired neurodevelopmental outcomes. Although hydrocortisone is often needed in the treatment of ELBW infants, clinicians should be aware that an increased dose of hydrocortisone may be associated with impaired neurodevelopmental outcomes.
DOI: 10.6084/m9.figshare.24648756
title: Supplementary Material for: LAG3 and TIGIT Expression on Tumor Infiltrating Lymphocytes in Cutaneous Melanoma.

description: Background: Melanoma is widely recognized to be an immunogenic tumor that often contains tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment (TME).During cancer progression, expression of ligands that bind immune checkpoint (IC) proteins, such as PD1, expressed on the surface of TILs, hinder them from exerting their antitumor functions. TILs consist of a heterogenous group of immune cells and their presence is associated with an improved overall survival (OS) in melanoma patients. Introduction of IC inhibitors has revolutionized management and prognosis of advanced melanoma. Unfortunately, the response rates have continued to be limited, resulting in growing interest in characterizing novel IC proteins, and developing combination therapy that includes inhibitors against multiple IC proteins. Methods: In a regional cohort of 166 patients diagnosed with cutaneous superficial spreading melanoma (SSM) with different degree of TILs, we investigated the tumor-immune associated gene expression profile using NanoString Technology. We used multiplex immunofluorescence (mIF) staining in a subset of tumors (N=7), combining IC proteins TIGIT and LAG3 with a melanoma cell marker (SOX10) and immune cell markers (CD8 (cytotoxic T cells), CD4 (T helper cells), FOXP3 (regulatory T cells/Tregs), PAX5 (B cells), and CD56 (NK/NKT cells)) and IC protein PD1. Results: We found upregulation of 91 differentially expressed genes, including IC proteins, LAG3 and TIGIT in melanomas with brisk TILs compared to tumors where TILs were absent. mIF staining revealed LAG3 and TIGIT expression in the majority of CD8+ T cells. Only few Tregs and CD4+ T cells expressed LAG3, whereas majority of them expressed TIGIT. LAG3 and TIGIT were expressed in a small fraction of the NK/NKT cells and lacked in the B cells. The majority of PD1+ cells co-localized with LAG3 and TIGIT. Conclusion: We report a variable expression of LAG3 and TIGIT on TILs subtypes and a coeval occurrence with PD1. This knowledge places LAG3 and TIGIT in spatial and cellular context in melanoma. The data suggest that targeting multiple IC proteins might help to overcome the current challenges with IC therapies.