cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30416734
title: Supplementary Material for: Research progress on lncRNA HCP5's regulation of hypertrophic scars by targeting miR-27b-3p

description: Introduction: Hypertrophic scars are common fibrotic disorders marked by fibroblast overgrowth and excessive extracellular matrix deposition, necessitating further research into their formation mechanisms to improve treatment outcomes. The study investigated the clinical significance and potential mechanisms of long noncoding RNA (lncRNA) HCP5 in the development of hypertrophic scars in human fibroblasts.
Methods: The study involved 63 patients to evaluate HCP5 expression through RT-qPCR. Cellular behaviors of human hypertrophic scar myofibroblasts (HSFs) were measured using CCK-8, Transwell, and flow cytometry assays. Targeting interactions between lncRNA HCP5 and miR-27b-3p were verified using a dual luciferase reporter assay.
Results: LncRNA HCP5 was significantly upregulated in hypertrophic scar tissue. More intriguingly, the silencing of lncRNA HCP5 led to a reduction in HSFs viability and migration, while simultaneously promoting apoptosis. Furthermore, miR-27b-3p was found to be downregulated and exhibited a negative correlation with lncRNA HCP5, both factors played crucial roles in regulating cellular behavior. In addition, the inhibition of miR-27b-3p may play a role in mitigating the effects induced by silenced lncRNA HCP5 on hypertrophic scars.
Conclusion: LncRNA HCP5 influenced the biological behavior of human hypertrophic scars by targeting miR-27b-3p.
DOI: 10.6084/m9.figshare.30416734.v1
title: Supplementary Material for: Research progress on lncRNA HCP5's regulation of hypertrophic scars by targeting miR-27b-3p

description: Introduction: Hypertrophic scars are common fibrotic disorders marked by fibroblast overgrowth and excessive extracellular matrix deposition, necessitating further research into their formation mechanisms to improve treatment outcomes. The study investigated the clinical significance and potential mechanisms of long noncoding RNA (lncRNA) HCP5 in the development of hypertrophic scars in human fibroblasts.
Methods: The study involved 63 patients to evaluate HCP5 expression through RT-qPCR. Cellular behaviors of human hypertrophic scar myofibroblasts (HSFs) were measured using CCK-8, Transwell, and flow cytometry assays. Targeting interactions between lncRNA HCP5 and miR-27b-3p were verified using a dual luciferase reporter assay.
Results: LncRNA HCP5 was significantly upregulated in hypertrophic scar tissue. More intriguingly, the silencing of lncRNA HCP5 led to a reduction in HSFs viability and migration, while simultaneously promoting apoptosis. Furthermore, miR-27b-3p was found to be downregulated and exhibited a negative correlation with lncRNA HCP5, both factors played crucial roles in regulating cellular behavior. In addition, the inhibition of miR-27b-3p may play a role in mitigating the effects induced by silenced lncRNA HCP5 on hypertrophic scars.
Conclusion: LncRNA HCP5 influenced the biological behavior of human hypertrophic scars by targeting miR-27b-3p.
DOI: 10.5517/cc11hw8p
title: CCDC 968572: Experimental Crystal Structure Determination

description: Related Article: Ananya Dutta, Antek G. Wong-Foy, Adam J. Matzger|2014|Chemical Science|5|3729|doi:10.1039/C3SC53549E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hw9q
title: CCDC 968573: Experimental Crystal Structure Determination

description: Related Article: Ananya Dutta, Antek G. Wong-Foy, Adam J. Matzger|2014|Chemical Science|5|3729|doi:10.1039/C3SC53549E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hzcw
title: CCDC 968668: Experimental Crystal Structure Determination

description: Related Article: S.-G. Wang, S.-L. You|2014|Angew.Chem.,Int.Ed.|53|2194|doi:10.1002/anie.201309876
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hzdx
title: CCDC 968669: Experimental Crystal Structure Determination

description: Related Article: S.-G. Wang, S.-L. You|2014|Angew.Chem.,Int.Ed.|53|2194|doi:10.1002/anie.201309876
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hy6p
title: CCDC 968632: Experimental Crystal Structure Determination

description: Related Article: N. Vinutha, S. Madan Kumar, Nithinchandra, K. Balakrishna, N.K. Lokanath, D. Revannasiddaiah|2013|Acta Crystallogr.,Sect.E:Struct.Rep.Online|69|o1724|doi:10.1107/S1600536813029425
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30416737
title: Supplementary Material for: Association of angiotensin inhibitors with improved outcome after acute intracerebral hemorrhage: secondary analysis of the INTERACT3 trial

description: Introduction: Drug screening with a zebrafish model of acute intracerebral hemorrhage (ICH) identified a neuroprotective effect of angiotensin converting enzyme inhibitor (ACE-I) drugs. We identified an association of early ACE-I treatment and favorable 90-day functional outcome in participants of the second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial. We aimed to confirm a relation between angiotensin inhibitors and good outcome in the larger, third INTEnsive care bundle with blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT3) dataset.
Methods: Post-hoc analysis of INTERACT3 in patients with ICH surviving to Day 7. Associations of early ACE-I or angiotensin-II receptor blockers (ARB) treatment and neurological impairment (National Institutes of Health Stroke Scale [NIHSS] scores) at Day 7 and functional recovery (modified Rankin scale [mRS] scores) at 6 months, were tested in multiple regression and ordinal regression models, respectively, with adjustment for confounding variables.
Results: Of 6692 participants included in analyses, 2525 (36.2%) received ACE-I/ARB treatment by Day 7. Treatment with an ACE-I/ARB (vs. no ACE-I/ARB) was significantly and independently associated with lower NIHSS scores at Day 7 (β-coefficient -1.17, 95% confidence interval [CI] -1.59 to -0.74; p &lt;0.001) and better mRS scores at 6 months (odds ratio 0.83, 95% CI 0.75 to 0.93; p=0.0007).
Conclusion: Early treatment with an angiotensin inhibitor is associated with improved outcome after ICH. Further research is needed to test for heterogeneity by ACE-I/ARB drug and treatment window to plan a clinical trial in ICH.
DOI: 10.6084/m9.figshare.30416737.v1
title: Supplementary Material for: Association of angiotensin inhibitors with improved outcome after acute intracerebral hemorrhage: secondary analysis of the INTERACT3 trial

description: Introduction: Drug screening with a zebrafish model of acute intracerebral hemorrhage (ICH) identified a neuroprotective effect of angiotensin converting enzyme inhibitor (ACE-I) drugs. We identified an association of early ACE-I treatment and favorable 90-day functional outcome in participants of the second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial. We aimed to confirm a relation between angiotensin inhibitors and good outcome in the larger, third INTEnsive care bundle with blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT3) dataset.
Methods: Post-hoc analysis of INTERACT3 in patients with ICH surviving to Day 7. Associations of early ACE-I or angiotensin-II receptor blockers (ARB) treatment and neurological impairment (National Institutes of Health Stroke Scale [NIHSS] scores) at Day 7 and functional recovery (modified Rankin scale [mRS] scores) at 6 months, were tested in multiple regression and ordinal regression models, respectively, with adjustment for confounding variables.
Results: Of 6692 participants included in analyses, 2525 (36.2%) received ACE-I/ARB treatment by Day 7. Treatment with an ACE-I/ARB (vs. no ACE-I/ARB) was significantly and independently associated with lower NIHSS scores at Day 7 (β-coefficient -1.17, 95% confidence interval [CI] -1.59 to -0.74; p &lt;0.001) and better mRS scores at 6 months (odds ratio 0.83, 95% CI 0.75 to 0.93; p=0.0007).
Conclusion: Early treatment with an angiotensin inhibitor is associated with improved outcome after ICH. Further research is needed to test for heterogeneity by ACE-I/ARB drug and treatment window to plan a clinical trial in ICH.
DOI: 10.5517/cc11hzwd
title: CCDC 968684: Experimental Crystal Structure Determination

description: Related Article: Bolin Zhu, Yuan Li|2014|Polyhedron|69|244|doi:10.1016/j.poly.2013.12.008
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hzxf
title: CCDC 968685: Experimental Crystal Structure Determination

description: Related Article: Christoph Schädle, Cäcilia Maichle-Mössmer, Karl W. Törnroos, and Reiner Anwander|2015|Organometallics|34|2667|doi:10.1021/acs.organomet.5b00013
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hzyg
title: CCDC 968686: Experimental Crystal Structure Determination

description: Related Article: Christoph Schädle, Cäcilia Maichle-Mössmer, Karl W. Törnroos, and Reiner Anwander|2015|Organometallics|34|2667|doi:10.1021/acs.organomet.5b00013
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11hzzh
title: CCDC 968687: Experimental Crystal Structure Determination

description: Related Article: Christoph Schädle, Cäcilia Maichle-Mössmer, Karl W. Törnroos, and Reiner Anwander|2015|Organometallics|34|2667|doi:10.1021/acs.organomet.5b00013
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.30416740
title: Supplementary Material for: Treatment moderators of symptom severity in psychotherapy for people with borderline personality disorder: Systematic review with meta-analyses of individual participant data

description: Background: Borderline personality disorder (BPD) is a complex and heterogeneous condition. Psychotherapy reduces symptom severity; however, characteristics of the individual may influence treatment outcomes. This systematic review examined whether specific baseline variables moderate the effect of psychotherapy on BPD severity through individual participant data meta-analysis (IPD-MA).
Methods: A literature search up to 12 May 2025 across 10 databases (including PubMed, Medline, Embase, PsychINFO, CINAHL, Web of Science, and Cochrane CENTRAL) identified randomised clinical trials (RCTs) comparing psychotherapy to treatment as usual (TAU) or clinical management control interventions (CM) for BPD. Authors of included trials were contacted to retrieve IPD. IPD-MAs employed a one-stage random-effects approach to estimate treatment effects and potential moderators in bivariate linear mixed-effects models. The study was registered with PROSPERO (CRD42021210688).
Results: Out of 33696 records identified, 42 RCTs (3848 participants) were eligible. IPD was obtained from 19 trials (1482 participants). All trials had an overall high risk of bias. There was a high rate of missing data across trials (378/1482, 25.1%). IPD-MA showed that psychotherapy significantly reduced BPD severity compared to TAU/CM (β: -.25, 95% CI: -.43 to -.07, SE: .09, p = .0065; 19 trials, 1104 participants). Significant negative moderators were co-occurring depressive disorder(s) (β: .31, 95% CI: .03 to .59) and exposure to sexual trauma (β: .60, 95% CI: .16 to 1.04). While positive moderators were co-occurring anxiety disorder(s) (β -.34, 95% CI: -.64 to -.03) and alcohol-use disorder(s) (AUD) (β -.34, 95% CI: -.67 to -.01). 
Conclusion: Psychotherapy may be especially beneficial for BPD with co-occurring anxiety. Patients with co-occurring AUD should not be excluded from treatment; rather, treatment motivation should be emphasised. Further, clinicians should prioritise trauma-informed care.
DOI: 10.6084/m9.figshare.30416740.v1
title: Supplementary Material for: Treatment moderators of symptom severity in psychotherapy for people with borderline personality disorder: Systematic review with meta-analyses of individual participant data

description: Background: Borderline personality disorder (BPD) is a complex and heterogeneous condition. Psychotherapy reduces symptom severity; however, characteristics of the individual may influence treatment outcomes. This systematic review examined whether specific baseline variables moderate the effect of psychotherapy on BPD severity through individual participant data meta-analysis (IPD-MA).
Methods: A literature search up to 12 May 2025 across 10 databases (including PubMed, Medline, Embase, PsychINFO, CINAHL, Web of Science, and Cochrane CENTRAL) identified randomised clinical trials (RCTs) comparing psychotherapy to treatment as usual (TAU) or clinical management control interventions (CM) for BPD. Authors of included trials were contacted to retrieve IPD. IPD-MAs employed a one-stage random-effects approach to estimate treatment effects and potential moderators in bivariate linear mixed-effects models. The study was registered with PROSPERO (CRD42021210688).
Results: Out of 33696 records identified, 42 RCTs (3848 participants) were eligible. IPD was obtained from 19 trials (1482 participants). All trials had an overall high risk of bias. There was a high rate of missing data across trials (378/1482, 25.1%). IPD-MA showed that psychotherapy significantly reduced BPD severity compared to TAU/CM (β: -.25, 95% CI: -.43 to -.07, SE: .09, p = .0065; 19 trials, 1104 participants). Significant negative moderators were co-occurring depressive disorder(s) (β: .31, 95% CI: .03 to .59) and exposure to sexual trauma (β: .60, 95% CI: .16 to 1.04). While positive moderators were co-occurring anxiety disorder(s) (β -.34, 95% CI: -.64 to -.03) and alcohol-use disorder(s) (AUD) (β -.34, 95% CI: -.67 to -.01). 
Conclusion: Psychotherapy may be especially beneficial for BPD with co-occurring anxiety. Patients with co-occurring AUD should not be excluded from treatment; rather, treatment motivation should be emphasised. Further, clinicians should prioritise trauma-informed care.
DOI: 10.13140/rg.2.2.29462.87369
title: A importância da conservação ex-situ na luta contra a extinção
DOI: 10.5517/cc11j00l
title: CCDC 968688: Experimental Crystal Structure Determination

description: Related Article: Christoph Schädle, Cäcilia Maichle-Mössmer, Karl W. Törnroos, and Reiner Anwander|2015|Organometallics|34|2667|doi:10.1021/acs.organomet.5b00013
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11j01m
title: CCDC 968689: Experimental Crystal Structure Determination

description: Related Article: Louis C. Morrill, Samuel M. Smith, Alexandra M. Z. Slawin and Andrew D. Smith|2014|J.Org.Chem.|79|1640|doi:10.1021/jo402591v
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11j02n
title: CCDC 968690: Experimental Crystal Structure Determination

description: Related Article: Louis C. Morrill, Samuel M. Smith, Alexandra M. Z. Slawin and Andrew D. Smith|2014|J.Org.Chem.|79|1640|doi:10.1021/jo402591v
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11j03p
title: CCDC 968691: Experimental Crystal Structure Determination

description: Related Article: Louis C. Morrill, Samuel M. Smith, Alexandra M. Z. Slawin and Andrew D. Smith|2014|J.Org.Chem.|79|1640|doi:10.1021/jo402591v
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11j04q
title: CCDC 968692: Experimental Crystal Structure Determination

description: Related Article: Louis C. Morrill, Samuel M. Smith, Alexandra M. Z. Slawin and Andrew D. Smith|2014|J.Org.Chem.|79|1640|doi:10.1021/jo402591v
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11j05r
title: CCDC 968693: Experimental Crystal Structure Determination

description: Related Article: Louis C. Morrill, Samuel M. Smith, Alexandra M. Z. Slawin and Andrew D. Smith|2014|J.Org.Chem.|79|1640|doi:10.1021/jo402591v
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc11j06s
title: CCDC 968694: Experimental Crystal Structure Determination

description: Related Article: J. M. Li, X. Zhang, Z. F. Shi, K. H. He|2014|Koord.Khim.|40|515|doi:10.1134/S1070328414070057
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc114ld5
title: CCDC 957726: Experimental Crystal Structure Determination

description: Related Article: Helen C. Aspinall, John Bacsa, Oliver D. Beckingham, Edward G. B. Eden, Nicholas Greeves, Matthew D. Hobbs, Frances Potjewyd, Marc Schmidtmann, Christopher D. Thomas|2014|Dalton Trans.|43|1434|doi:10.1039/C3DT52366G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc114lf6
title: CCDC 957727: Experimental Crystal Structure Determination

description: Related Article: Helen C. Aspinall, John Bacsa, Oliver D. Beckingham, Edward G. B. Eden, Nicholas Greeves, Matthew D. Hobbs, Frances Potjewyd, Marc Schmidtmann, Christopher D. Thomas|2014|Dalton Trans.|43|1434|doi:10.1039/C3DT52366G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc114lg7
title: CCDC 957728: Experimental Crystal Structure Determination

description: Related Article: Helen C. Aspinall, John Bacsa, Oliver D. Beckingham, Edward G. B. Eden, Nicholas Greeves, Matthew D. Hobbs, Frances Potjewyd, Marc Schmidtmann, Christopher D. Thomas|2014|Dalton Trans.|43|1434|doi:10.1039/C3DT52366G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc114lh8
title: CCDC 957729: Experimental Crystal Structure Determination

description: Related Article: Helen C. Aspinall, John Bacsa, Oliver D. Beckingham, Edward G. B. Eden, Nicholas Greeves, Matthew D. Hobbs, Frances Potjewyd, Marc Schmidtmann, Christopher D. Thomas|2014|Dalton Trans.|43|1434|doi:10.1039/C3DT52366G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.