cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6273686.v1
title: Relationship between mental health and everyday cognitive failures: role of internalizing and externalizing symptoms

description: ABSTRACT Objective Cognitive failures are errors made in everyday life such as forgetting appointments, lack of words when talking, difficulties to memorize what is read, errors of orientation, among others. Internalizing and externalizing psychiatric symptoms may contribute to the occurrence of cognitive failures. The present study aims to evaluate how internalizing and externalizing symptoms contribute to the occurrence of everyday cognitive failures. Methods We evaluated 366 volunteers using the Cognitive Failure Questionnaire (CFQ), the Self-Reporting Questionnaire-20 (SRQ-20) as a measure of internalizing symptoms and the Adult Self-Report Scale (ASRS-18) as a measure of externalizing symptoms. We classified the participants based on the SRQ-20 and ASRS-18 cut-off scores to create four groups: controls, internalizing, externalizing, and mixed. We compared the groups by means of ANOVA and tested its associations with correlations. Results All scales showed strong correlations between each other (r &gt; 0.500, p &lt; 0.001). The comparison of the groups suggests that participants with clinical scores of internalizing and externalizing symptoms have more failures when compared to the control group (d = 0.86 and d = 1.00), but they do not present differences between themselves (d = 0.21). Participants of the mixed group presented more failures than the control group (d = 2.01), and the internalizing (d = 1.31) and externalizing (d = 1.05) groups. Conclusion Both internalizing and externalizing symptoms contribute to the occurrence of day-to-day cognitive failures. We also observed an additive effect of both symptoms.
DOI: 10.6084/m9.figshare.6273683
title: Comparison of two artificial diets to rear Elaphria agrotina

description: ABSTRACT: Given the increasing importance of Elaphria agrotina (Guenée) (Lepidoptera: Noctuidae) in corn crops, especially in the Brazilian Savannah biome, the present research aimed to study its development and survival on Greene’s and Poitout & Bues’s artificial diets (25±1°C, 70±10% relative humidity [RH] and 12h photophase). Poitout & Bues’s diet was more suitable than Greene’s diet, providing higher survival percent (77.51% vs. 5.57%), lower development time (49.81 days vs. 55.24 days) and higher fecundity (167.65 vs. 84.9 eggs), respectively. All the caterpillars reared on Poitout & Bues’s diet passed through six instars, while almost half of the larvae reared on Greene’s diet went through one less instar stage. Regarding the main reproductive parameters, higher average time of generation (T) and lower values of net rates of reproduction (Ro), and increased (rm) intrinsic and finite reason of increase (λ), were observed for larvae reared on Greene’s diet. Results presented in this study indicated that Poitout & Bues’s diet is more suitable for maintenance of colonies of E. agrotina as compared to Greene’s diet.
DOI: 10.6084/m9.figshare.6273683.v1
title: Comparison of two artificial diets to rear Elaphria agrotina

description: ABSTRACT: Given the increasing importance of Elaphria agrotina (Guenée) (Lepidoptera: Noctuidae) in corn crops, especially in the Brazilian Savannah biome, the present research aimed to study its development and survival on Greene’s and Poitout & Bues’s artificial diets (25±1°C, 70±10% relative humidity [RH] and 12h photophase). Poitout & Bues’s diet was more suitable than Greene’s diet, providing higher survival percent (77.51% vs. 5.57%), lower development time (49.81 days vs. 55.24 days) and higher fecundity (167.65 vs. 84.9 eggs), respectively. All the caterpillars reared on Poitout & Bues’s diet passed through six instars, while almost half of the larvae reared on Greene’s diet went through one less instar stage. Regarding the main reproductive parameters, higher average time of generation (T) and lower values of net rates of reproduction (Ro), and increased (rm) intrinsic and finite reason of increase (λ), were observed for larvae reared on Greene’s diet. Results presented in this study indicated that Poitout & Bues’s diet is more suitable for maintenance of colonies of E. agrotina as compared to Greene’s diet.
DOI: 10.6084/m9.figshare.6273677
title: The Mato Perso Conduit System: evidence of silicic magma transport in the southern portion of the Paraná-Etendeka LIP, Brazil

description: ABSTRACT: The Mato Perso Conduit System is described from a ~ 120 km2 area in south Brazil exposing silicic volcanics of the Paraná-Etendeka LIP. A volcanic succession is defined by basaltic flows covered by flat-lying oxidized vitrophyres, banded vitrophyres cutting the lower lavas and grey flat-lying vitrophyres covering all the units. Flow morphologies determined by the recognition of structures, textures, and vesicle distribution were observed. Oxidized vitrophyres display massive flat-lying banded cores and flow tops from vesicular to frothy. Grey flat-lying vitrophyres have sharp contacts in the top of both basalt flows and oxidized vitrophyres, locally exhibit basal breccia and have a flat-lying foliation. Conduits are represented by banded vitrophyres and breccias, which outcrop in a 6 km wide, NW-SE oriented segment downthrown by normal faults towards the Antas River. The interpretation of the units on the geological map scale indicates intrusive contact relations. Recognition of dike-like structures in banded vitrophyres and dykes of oxidized vitrophyre are evidence of felsic magma transport. Based on field observations, we propose the emplacement of subaerial oxidized and grey vitrophyres fed by a fault-related conduit system. Sustained high temperature magmatic systems ensure the silicic lavas have a low viscosity and travel great distances.
DOI: 10.6084/m9.figshare.6273674
title: Local geological sections and regional stratigraphy based on physical geology and chemical stratigraphy of the Serra Geral Group from Araraquara to Avaré, SP

description: ABSTRACT: From Araraquara to Avaré, in the Serra Geral Group outcropping area, 22 detailed geological sections were elaborated. The stratigraphic relationships and the chemical analysis allowed the identification of seven [P2O5] basalt classes, all of them pertaining to the Pitanga type, showing a consistent stacking order across the studied region. Thus, each class is considered to correspond to a specific lava flow, allowing a general stratigraphic column to be proposed. Besides the stacking order, the validation of P2O5 as a tool for lava correlation at great distances was also based on the values obtained from samples collected at different positions in a single flow, and on the remarkable [P2O5] contrast between adjacent flows. Minimum lateral extensions range from 75 to 185 km, and thickness from 20 to 80 m. Vertical tectonic displacements, which took place in different periods, were inferred from the altitude of specific flows, and also from the Botucatu and Piramboia formations. They are noticeable in a region bounded by EW drainage lineaments, which contains a large area where Piramboia and Botucatu formations crop out, probably due to the tectonic activity causing this region to be a generalized structural high.
DOI: 10.6084/m9.figshare.6273677.v1
title: The Mato Perso Conduit System: evidence of silicic magma transport in the southern portion of the Paraná-Etendeka LIP, Brazil

description: ABSTRACT: The Mato Perso Conduit System is described from a ~ 120 km2 area in south Brazil exposing silicic volcanics of the Paraná-Etendeka LIP. A volcanic succession is defined by basaltic flows covered by flat-lying oxidized vitrophyres, banded vitrophyres cutting the lower lavas and grey flat-lying vitrophyres covering all the units. Flow morphologies determined by the recognition of structures, textures, and vesicle distribution were observed. Oxidized vitrophyres display massive flat-lying banded cores and flow tops from vesicular to frothy. Grey flat-lying vitrophyres have sharp contacts in the top of both basalt flows and oxidized vitrophyres, locally exhibit basal breccia and have a flat-lying foliation. Conduits are represented by banded vitrophyres and breccias, which outcrop in a 6 km wide, NW-SE oriented segment downthrown by normal faults towards the Antas River. The interpretation of the units on the geological map scale indicates intrusive contact relations. Recognition of dike-like structures in banded vitrophyres and dykes of oxidized vitrophyre are evidence of felsic magma transport. Based on field observations, we propose the emplacement of subaerial oxidized and grey vitrophyres fed by a fault-related conduit system. Sustained high temperature magmatic systems ensure the silicic lavas have a low viscosity and travel great distances.
DOI: 10.6084/m9.figshare.6273674.v1
title: Local geological sections and regional stratigraphy based on physical geology and chemical stratigraphy of the Serra Geral Group from Araraquara to Avaré, SP

description: ABSTRACT: From Araraquara to Avaré, in the Serra Geral Group outcropping area, 22 detailed geological sections were elaborated. The stratigraphic relationships and the chemical analysis allowed the identification of seven [P2O5] basalt classes, all of them pertaining to the Pitanga type, showing a consistent stacking order across the studied region. Thus, each class is considered to correspond to a specific lava flow, allowing a general stratigraphic column to be proposed. Besides the stacking order, the validation of P2O5 as a tool for lava correlation at great distances was also based on the values obtained from samples collected at different positions in a single flow, and on the remarkable [P2O5] contrast between adjacent flows. Minimum lateral extensions range from 75 to 185 km, and thickness from 20 to 80 m. Vertical tectonic displacements, which took place in different periods, were inferred from the altitude of specific flows, and also from the Botucatu and Piramboia formations. They are noticeable in a region bounded by EW drainage lineaments, which contains a large area where Piramboia and Botucatu formations crop out, probably due to the tectonic activity causing this region to be a generalized structural high.
DOI: 10.6084/m9.figshare.6273671
title: First-wave protease inhibitors for hepatitis C genotype 1 treatment: a real-life experience in Brazilian patients

description: Abstract INTRODUCTION: Licensed for chronic hepatitis C treatment in 2011, the protease inhibitors (PIs) telaprevir (TVR) and boceprevir (BOC), which have high sustained viral responses (SVR), ushered a new era characterized by the development of direct-action drugs against the hepatitis C virus (HCV). The aim of this study was to analyze the effectiveness and safety of BOC and TVR administered with pegylated interferon and ribavirin and to share the experience of a Brazilian reference center. METHODS: A retrospective descriptive study was conducted in patients with HCV genotype 1 infection who started treatment between July 2013 and December 2015. Data were collected using a computerized system. RESULTS: A total of 115 subjects were included, of which 58 (50.4 %) had liver cirrhosis and 103 (89.6 %) used TVR. The overall SVR rate was 61.7 % (62.1 % for TVR and 58.3 % for BOC). The presence of cirrhosis was associated with a lower SVR rate, whereas patients who relapsed after prior therapy had a greater chance of showing SVR than did non-responders. The incidence of adverse drug reactions (ADRs) was high. Almost all patients (~100 %) presented with hematologic events. Furthermore, treatment had to be discontinued in 15 subjects (13 %) due to severe ADRs. CONCLUSIONS: In conclusion, the SVR rates in our study were lower than those reported in pre-marketing studies but were comparable to real-life data. ADRs, particularly hematological ADRs, were more common compared to those in previous studies and resulted in a high rate of treatment discontinuity.
DOI: 10.6084/m9.figshare.6273671.v1
title: First-wave protease inhibitors for hepatitis C genotype 1 treatment: a real-life experience in Brazilian patients

description: Abstract INTRODUCTION: Licensed for chronic hepatitis C treatment in 2011, the protease inhibitors (PIs) telaprevir (TVR) and boceprevir (BOC), which have high sustained viral responses (SVR), ushered a new era characterized by the development of direct-action drugs against the hepatitis C virus (HCV). The aim of this study was to analyze the effectiveness and safety of BOC and TVR administered with pegylated interferon and ribavirin and to share the experience of a Brazilian reference center. METHODS: A retrospective descriptive study was conducted in patients with HCV genotype 1 infection who started treatment between July 2013 and December 2015. Data were collected using a computerized system. RESULTS: A total of 115 subjects were included, of which 58 (50.4 %) had liver cirrhosis and 103 (89.6 %) used TVR. The overall SVR rate was 61.7 % (62.1 % for TVR and 58.3 % for BOC). The presence of cirrhosis was associated with a lower SVR rate, whereas patients who relapsed after prior therapy had a greater chance of showing SVR than did non-responders. The incidence of adverse drug reactions (ADRs) was high. Almost all patients (~100 %) presented with hematologic events. Furthermore, treatment had to be discontinued in 15 subjects (13 %) due to severe ADRs. CONCLUSIONS: In conclusion, the SVR rates in our study were lower than those reported in pre-marketing studies but were comparable to real-life data. ADRs, particularly hematological ADRs, were more common compared to those in previous studies and resulted in a high rate of treatment discontinuity.
DOI: 10.6084/m9.figshare.6273662
title: Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

description: Abstract Purpose: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. Methods: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts. All animals had one defect left unfilled to serve as controls. Five animals in each group were sacrificed at 4 and 8 weeks. Histomorphometric analysis was used to quantify the amount of new bone within the defects. Results: The results showed that demineralized bone matrix-treated defects had significantly more new bone at 4 weeks compared to calcium phosphate cement-treated defects (p=0.03) and also had significantly more new bone at 8 weeks compared to unfilled defects (p=0.04). Conclusions: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended.
DOI: 10.6084/m9.figshare.6273662.v1
title: Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

description: Abstract Purpose: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. Methods: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts. All animals had one defect left unfilled to serve as controls. Five animals in each group were sacrificed at 4 and 8 weeks. Histomorphometric analysis was used to quantify the amount of new bone within the defects. Results: The results showed that demineralized bone matrix-treated defects had significantly more new bone at 4 weeks compared to calcium phosphate cement-treated defects (p=0.03) and also had significantly more new bone at 8 weeks compared to unfilled defects (p=0.04). Conclusions: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended.
DOI: 10.6084/m9.figshare.6273653
title: On the creep behavior of carbon/epoxy non-crimp fabric composites

description: The use of composites in structural applications requires the study of specific properties to ensure that these materials are safe and an excellent option to replace some metals, for example. In the present study, vacuum assisted resin transfer molding (VARTM) was used prior to obtain carbon/epoxy non-crimp fabric composites. Dynamic mechanical analysis and creep - by using Findley and Burger's methods - tests were performed aiming to evaluate the viscoelastic properties of the composites, in three different temperatures (30, 60 and 90°C) and static stresses (2, 5 and 10 MPa). The viscoelastic properties were also discussed using Weibull parameters obtained from creep curves. In general, the deformation was temperature and stress dependent, which was corroborated by the viscoelastic parameters obtained from both models.
DOI: 10.6084/m9.figshare.6273653.v1
title: On the creep behavior of carbon/epoxy non-crimp fabric composites

description: The use of composites in structural applications requires the study of specific properties to ensure that these materials are safe and an excellent option to replace some metals, for example. In the present study, vacuum assisted resin transfer molding (VARTM) was used prior to obtain carbon/epoxy non-crimp fabric composites. Dynamic mechanical analysis and creep - by using Findley and Burger's methods - tests were performed aiming to evaluate the viscoelastic properties of the composites, in three different temperatures (30, 60 and 90°C) and static stresses (2, 5 and 10 MPa). The viscoelastic properties were also discussed using Weibull parameters obtained from creep curves. In general, the deformation was temperature and stress dependent, which was corroborated by the viscoelastic parameters obtained from both models.
DOI: 10.6084/m9.figshare.6273650
title: Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage

description: BACKGROUND Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. FINDINGS ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distribution of the virus to organs and tissues. MAIN CONCLUSIONS Biomarker network analysis demonstrated distinct dynamics in concurrence with the bimodal viremia profiles at different time points during ZIKV infection. Such a robust cytokine and chemokine response has been associated with blood-brain barrier permeability and neuroinvasiveness in other flaviviral infections. High-dimensional data analysis further identified CXCL10, a chemokine involved in foetal neuron apoptosis and Guillain-Barré syndrome, as the most promising biomarker of acute ZIKV infection for potential clinical application.
DOI: 10.6084/m9.figshare.6273650.v1
title: Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage

description: BACKGROUND Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. FINDINGS ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distribution of the virus to organs and tissues. MAIN CONCLUSIONS Biomarker network analysis demonstrated distinct dynamics in concurrence with the bimodal viremia profiles at different time points during ZIKV infection. Such a robust cytokine and chemokine response has been associated with blood-brain barrier permeability and neuroinvasiveness in other flaviviral infections. High-dimensional data analysis further identified CXCL10, a chemokine involved in foetal neuron apoptosis and Guillain-Barré syndrome, as the most promising biomarker of acute ZIKV infection for potential clinical application.
DOI: 10.6084/m9.figshare.6273641
title: Peculiar Properties of Phase Transitions in Na0.5Bi0.5TiO3-xBaTiO3 (0

description: Na0.5Bi0.5TiO3-xBaTiO3 (0
DOI: 10.6084/m9.figshare.6273638
title: Entomological investigation of Japanese encephalitis outbreak in Malkangiri district of Odisha state, India

description: BACKGROUND A severe outbreak of Japanese encephalitis (JE) and acute encephalitis syndrome (AES) with high case fatality was reported from Malkangiri district of Odisha state, India during September to November 2016 affecting 336 children with 103 deaths. OBJECTIVES The purpose of this study was to investigate the outbreak in the light of entomological determinants. METHODS Entomological investigation was carried out in 48 villages from four mostly affected Community Health Centres (CHCs) of Malkangiri district. Dusk collections of resting adults was done in villages from indoor and outdoor sites to record the density of mosquito species, including the known JE vectors, feeding behaviour, parity, dusk index and infection status with JE virus (JEV). FINDINGS The per man hour density and dusk index of JE vector species varied from 2.5 to 24.0 and 0.81 to 7.62, respectively in study villages. A total of 1136 mosquitoes belonging to six vector species were subjected to PCR and one pool of Culex vishnui was found to be positive for JEV. CONCLUSION The JE transmission in Malkangiri district was confirmed. Thorough screening of human blood samples of JE/AES suspected cases and JE vector mosquitoes for the presence of JEV during rainy season every year is recommended.