cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4892780
title: ACTwatch Outlet Survey Files: Uganda 2015

description: ACTwatch Uganda 2015 files This fileset contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Uganda 2015 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the first reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4892852
title: MSR 18 Bayesian Hierarchical Modeling Thresholds Code

description: Replication package (Jupyter notebook) for MSR 18 submission on tailoring code thresholds with Bayesian hierarchical models.
DOI: 10.6084/m9.figshare.4892759
title: ACTwatch Outlet Survey Files: Tanzania 2016

description: ACTwatch Tanzania 2016 files This fileset contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Tanzania 2016 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4892852.v1
title: MSR 18 Bayesian Hierarchical Modeling Thresholds Code

description: Replication package (Jupyter notebook) for MSR 18 submission on tailoring code thresholds with Bayesian hierarchical models.
DOI: 10.6084/m9.figshare.4892717
title: ACTwatch Outlet Survey Files: Nigeria 2015

description: ACTwatch Nigeria 2015 files This fileset contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Nigeria 2015 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the first reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4892750
title: Latitudinal gradient in insect immunity

description: Among-population differences of two parameters reflecting constitutive immunity – phenoloxidase (PO) and lytic activity – using common garden design on three distantly related moth species represented by populations ranging from northern Finland to Georgia (Caucasus). <br><br>
DOI: 10.6084/m9.figshare.4892696
title: ACTwatch Outlet Survey Files: Myanmar 2015

description: ACTwatch Myanmar 2015 files This collection contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Myanmar 2015 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the first reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.
DOI: 10.6084/m9.figshare.4892690
title: Supplementary Material for: Diagnostic Accuracy of Combinations of Tumor Markers for Malignant Pleural Effusion: An Updated Meta-Analysis

description: <b><i>Background:</i></b> The role of combinations of tumor markers such as carcinoembryonic antigen (CEA), carbohydrate antigens (CA) 125, 15-3, and 19-9, and CYFRA 21-1 (a fragment of cytokeratin 19) in diagnosing malignant pleural effusion (MPE) has not been clearly established. <b><i>Objectives:</i></b> This meta-analysis was performed to establish the overall diagnostic accuracies of combinations of these pleural fluid tumor markers for MPE. <b><i>Methods:</i></b> The PubMed, Ovid, Embase, Web of Science, and Cochrane bibliographic databases were searched. Sensitivity, specificity, and other measures of the accuracy of combinations of pleural CEA, CA 125, CA 15-3, CA 19-9, and CYFRA 21-1 in the diagnosis of MPE were pooled after a systematic review of English-language studies. <b><i>Results:</i></b> Twenty studies met the inclusion criteria. For pleural fluid tumor marker combinations including more than 3 studies, the summary estimates of the sensitivity/specificity for diagnosing MPE were as follows: CEA + CA 125, 0.65/0.98; CEA + CA 15-3, 0.64/0.98; CEA + CA 19-9, 0.58/0.98; CEA + CYFRA 21-1, 0.82/0.92; and CA 15-3 + CYFRA 21-1, 0.88/0.94. <b><i>Conclusions:</i></b> In patients with undiagnosed pleural effusion, the combinations of positive pleural CEA + CA 15-3 and CEA + CA 19-9 are highly suspicious for pleural malignancy, but the sensitivity of these tests is poor. Therefore, their routine role in the diagnostic algorithm of these patients is questionable, and management decisions should depend on positive cytological or biopsy results from the pleura.
DOI: 10.6084/m9.figshare.4892693
title: Supplementary Material for: Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy

description: <b><i>Background:</i></b> The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. <b><i>Methods:</i></b> From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. <b><i>Results:</i></b> Of the 639 patients (male, 61%; age 69 ± 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). <b><i>Conclusion:</i></b> In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months.
DOI: 10.6084/m9.figshare.4892681
title: Supplementary Material for: Expression of High Mobility Group Protein B1 in Cardiac Tissue of Elderly Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease

description: <b><i>Background:</i></b> It is known from clinical practice and observational studies that elderly patients with a diagnosis of inflammatory rheumatic diseases (IRD) bear a significantly increased risk for cardiovascular diseases such as coronary artery disease (CAD) and heart failure. The molecular mechanism, however, is still not known. Recently, high mobility group protein B1 (HMGB1), a ubiquitous, highly conserved single polypeptide expressed in all mammal eukaryotic cells, has been identified to mediate myocardial dysfunction in vitro once released from the nuclei of cardiomyocytes. <b><i>Objective:</i></b> To investigate whether HMGB1 and its receptors are expressed in cardiac muscles of elderly patients with CAD with or without IRD. <b><i>Methods:</i></b> HMGB1 and its 3 well-known receptors, receptor for advanced glycation end products, Toll-like receptor 2 (TLR2), and TLR4, were examined by immunohistochemistry on myocardial biopsy specimens from 18 elderly patients with CAD (10 with IRD, 8 without IRD). Furthermore, total HMGB1 protein levels were measured by Western blot from the cardiac biopsies in 5 patients with and 5 without IRD. <b><i>Results:</i></b> Pathologic cytosolic HMGB1 in cardiomyocytes was massively recorded in all patients with IRD, but only slightly expressed in 1 patient without IRD. Total HMGB1 levels were also consistently lower in myocardial muscle biopsies of patients with IRD compared to those without IRD. Furthermore, all 3 HMGB1 receptors were expressed in cardiomyocytes of all patients. <b><i>Conclusion:</i></b> The increased cytosolic expression of HMGB1 in cardiomyocytes and the lower total amount of HMGB1 in the cardiac specimens of IRD patients is consistent with a greater release of HMGB1 from the myocardial nuclei in IRD than non-IRD individuals. Thus, the HMGB1 signaling pathways may be more easily activated in elderly CAD patients with concomitant IRD and trigger a detrimental inflammatory process causing severe cardiovascular problems. Therefore, targeting HMGB1 in IRD patients might reduce the risk for cardiovascular events.
DOI: 10.6084/m9.figshare.4892687
title: ACTwatch Outlet Survey Files: Madagascar 2015

description: ACTwatch Madagascar 2015 files This collection contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Madagascar 2015 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the first reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4892675
title: Supplementary Material for: Predictive Validity of Two Physical Frailty Phenotype Specifications Developed for Investigation of Frailty Pathways in Older People

description: <b><i>Background:</i></b> For investigating the relationship of frailty with physical, psychological, and social conditions on pathways, the frailty definition should ideally exclude these conditions. Based on the frailty phenotype, 2 candidate physical frailty specifications or instruments with 3 indicators, namely slowness, weakness, and exhaustion, and 4 indicators with addition of weight loss were previously developed, and had their construct and concurrent validity demonstrated. <b><i>Objective:</i></b> This study seeks to evaluate the predictive validity of 2 candidate physical frailty specifications with respect to death, functional impairment, and poor quality of life in older people. <b><i>Methods:</i></b> For 4,368 respondents aged 65-89 years from wave 2 of the English Longitudinal Study of Ageing, confirmatory factor analysis is performed for these 2 physical frailty specifications to obtain unique factor scores for each respondent. Prediction of death, basic and instrumental activities of daily living (BADL and IADL) difficulty, and poor quality of life (reverse of Control, Autonomy, Self-realization, and Pleasure [19 items] or CASP-19) 2 years later by factor scores for these 2 specifications is evaluated using standardized coefficients, c-statistics, and <i>r</i><sup>2</sup> values from regression analyses. Their performance is compared with those of alternative specifications with 3 (slowness, weakness, and weight loss) and 5 indicators (slowness, weakness, exhaustion, weight loss, and low physical activity), and Frailty Index (FI). <b><i>Results:</i></b> For the 2 candidate specifications, an increase of 1 standard deviation (SD) predicts 50-57% increase in odds of death, 0.10-15 SD increase in change in BADL or IADL difficulty, and poor quality of life at 2 years. They predict these outcomes as well or better than the alternative specification with 3 indicators, but marginally worse than that with 5 indicators. Compared with FI, they predict death and poor quality of life similarly, but perform worse for functional impairment. Minor differences are observed across gender. <b><i>Conclusion:</i></b> Reasonable predictive validity of 2 candidate physical frailty specifications based on the frailty phenotype with 3 and 4 indicators is demonstrated for death, functional impairment, and poor quality of life. These findings offer evidence to support their suitability for employment in investigating frailty pathways in older people.
DOI: 10.6084/m9.figshare.4892669
title: ACTwatch Outlet Survey Files: Lao PDR 2015

description: ACTwatch Lao PDR 2015 files This collection contains the questionnaire, codebook, reference document and dataset (in Stata .dta format) for the Lao PDR 2015 ACTwatch outlet survey. Started in 2008, ACTwatch was intended to fill evidence gaps related to malaria diagnostics, antimalarial medicines and fever case management in the private and public sectors. ACTwatch collected data to inform evidence-based malaria control policies and programmes. ACTwatch was a PSI research project in partnership with LSHTM. ACTwatch measured nationally representative surveys to all public and private health outlets within selected regions, across a total of 12 countries in sub-Saharan Africa and the Greater Mekong Sub-region and multiple years. Outlet Surveys monitored trends in the availability, volumes, and prices of antimalarials in the public and private sectors, which included the informal sector. All outlet types with the potential to sell antimalarials were included, from hospitals to private pharmacies to street hawkers. The collection and processing of these data provided sound evidence for country-specific policy recommendations. The use of standardized indicators allowed for broad trends to be identified and global policy recommendations to be implemented into policy and action.A guidance document containing comprehensive information on the ACTwatch project, design, questionnaires and data can be found by clicking on the reference link below.All potential data users are encouraged to review this document before analyzing any ACTwatch data.Note: version 2 of this record replaces the original files containing indirect identifying information in the outlet survey<br>
DOI: 10.6084/m9.figshare.4892681.v1
title: Supplementary Material for: Expression of High Mobility Group Protein B1 in Cardiac Tissue of Elderly Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease

description: <b><i>Background:</i></b> It is known from clinical practice and observational studies that elderly patients with a diagnosis of inflammatory rheumatic diseases (IRD) bear a significantly increased risk for cardiovascular diseases such as coronary artery disease (CAD) and heart failure. The molecular mechanism, however, is still not known. Recently, high mobility group protein B1 (HMGB1), a ubiquitous, highly conserved single polypeptide expressed in all mammal eukaryotic cells, has been identified to mediate myocardial dysfunction in vitro once released from the nuclei of cardiomyocytes. <b><i>Objective:</i></b> To investigate whether HMGB1 and its receptors are expressed in cardiac muscles of elderly patients with CAD with or without IRD. <b><i>Methods:</i></b> HMGB1 and its 3 well-known receptors, receptor for advanced glycation end products, Toll-like receptor 2 (TLR2), and TLR4, were examined by immunohistochemistry on myocardial biopsy specimens from 18 elderly patients with CAD (10 with IRD, 8 without IRD). Furthermore, total HMGB1 protein levels were measured by Western blot from the cardiac biopsies in 5 patients with and 5 without IRD. <b><i>Results:</i></b> Pathologic cytosolic HMGB1 in cardiomyocytes was massively recorded in all patients with IRD, but only slightly expressed in 1 patient without IRD. Total HMGB1 levels were also consistently lower in myocardial muscle biopsies of patients with IRD compared to those without IRD. Furthermore, all 3 HMGB1 receptors were expressed in cardiomyocytes of all patients. <b><i>Conclusion:</i></b> The increased cytosolic expression of HMGB1 in cardiomyocytes and the lower total amount of HMGB1 in the cardiac specimens of IRD patients is consistent with a greater release of HMGB1 from the myocardial nuclei in IRD than non-IRD individuals. Thus, the HMGB1 signaling pathways may be more easily activated in elderly CAD patients with concomitant IRD and trigger a detrimental inflammatory process causing severe cardiovascular problems. Therefore, targeting HMGB1 in IRD patients might reduce the risk for cardiovascular events.
DOI: 10.6084/m9.figshare.4892630
title: 3D human pyramidal dendrites with spines

description: R workspace with the five human pyramidal neurons used in the paper "Three-dimensional spatial modeling of spines along dendritic networks in human cortical pyramidal neurons". The workspace contains two hyperframes called apical and basal with the apical and basal dendrites of the analyzed cells, respectively, in the same order in which they appear in the paper. Use spatstat package for a proper visualization of the data. Each hyperframe consists in three columns: vertices: three-dimensional point pattern specifying the vertices of the dendritic network. m: adjacency matrix of logical values equal to TRUE when the corresponding vertices are joined by a line. X: three-dimensional point pattern specifying the locations of the spines in the network.