cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.urgd4e
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Basella alba",
 "Country is Madagascar",
 "HasCoordinate is true"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025228-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7qwqtn
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Basella alba",
 "Country is Maldives",
 "HasCoordinate is true"
 ]
}

 The dataset includes 6 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025230-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9vs4vn
title: Occurrence Download

description: A dataset containing 688 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gunnera perpensa",
 "Geometry POLYGON ((-17.62504 -34.81917, 51.13387 -34.81917, 51.13387 37.34999, -17.62504 37.34999, -17.62504 -34.81917))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 688 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025229-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qddzby
title: Occurrence Download

description: A dataset containing 55 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Callicarpa bodinieri bodinieri"
 ]
}

 The dataset includes 55 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025227-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dffemb
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Amphibia",
 "Geometry POLYGON ((54.0789 -15.6465, 54.0525 -15.9401, 54.9903 -15.9401, 54.9893 -15.6985, 54.6906 -15.4224, 54.2949 -15.439, 54.0789 -15.6465))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025231-250827131500795/datasets/export for details.
DOI: 10.5281/zenodo.16735605
title: Untargeted Metabolomics of SPP1-Treated 3T3-L1 Adipocytes (Raw mzML Files)

description: This dataset contains raw LC-MS/MS files (.mzML format) derived from differentiated 3T3-L1 adipocytes treated with recombinant osteopontin (SPP1) at two concentrations: low dose (100 ng/mL, SL) and high dose (500 ng/mL, SH). Vehicle-treated cells (N) served as the control group.

Samples were analyzed using untargeted LC-MS-based metabolomics in positive ion mode. Raw data were acquired using an LC-MS system and subsequently converted to .mzML format using MSConvert.

Experimental groups and sample identifiers:

N (vehicle-treated control): N1, N2, N3

SL (SPP1, 100 ng/mL): SL1, SL2, SL3

SH (SPP1, 500 ng/mL): SH1, SH2, SH3

These data were generated to investigate the dose-dependent metabolic impact of SPP1 on adipocyte function.The dataset is currently under embargo and will be made publicly available upon acceptance or publication of the associated manuscript.
DOI: 10.5281/zenodo.16735606
title: Untargeted Metabolomics of SPP1-Treated 3T3-L1 Adipocytes (Raw mzML Files)

description: This dataset contains raw LC-MS/MS files (.mzML format) derived from differentiated 3T3-L1 adipocytes treated with recombinant osteopontin (SPP1) at two concentrations: low dose (100 ng/mL, SL) and high dose (500 ng/mL, SH). Vehicle-treated cells (N) served as the control group.

Samples were analyzed using untargeted LC-MS-based metabolomics in positive ion mode. Raw data were acquired using an LC-MS system and subsequently converted to .mzML format using MSConvert.

Experimental groups and sample identifiers:

N (vehicle-treated control): N1, N2, N3

SL (SPP1, 100 ng/mL): SL1, SL2, SL3

SH (SPP1, 500 ng/mL): SH1, SH2, SH3

These data were generated to investigate the dose-dependent metabolic impact of SPP1 on adipocyte function.The dataset is currently under embargo and will be made publicly available upon acceptance or publication of the associated manuscript.
DOI: 10.6084/m9.figshare.30050953
title: Supplementary Material for: Combination Therapy for Simple Obesity: Acupoint Needling and Auricular Acupressure Effects

description: Introduction: To evaluate the efficacy and safety of acupoint-embedded needling combined with auricular acupressure in treating simple obesity associated with spleen deficiency and dampness accumulation.
Methods: Ninety-six patients with simple obesity were randomized into two groups. The intervention group received acupoint-embedded needling and auricular acupressure, while the control group received conventional acupuncture. After 30 days, body weight, body mass index (BMI), waist circumference, blood lipid profiles, traditional Chinese medicine (TCM) syndrome scores, and metabolic markers were assessed. These included homeostasis model assessment of insulin resistance (HOMA-IR), serum leptin, high-sensitivity C-reactive protein (hs-CRP), body fat percentage, and basal metabolic rate (BMR). Adverse events were monitored.
Results: Compared to the control group, the intervention group showed significantly greater reductions in body weight, BMI, waist circumference, total cholesterol, triglycerides, and low-density lipoprotein cholesterol, as well as increases in high-density lipoprotein cholesterol (all p &lt; 0.05). TCM scores and metabolic indicators also showed significant improvement. The overall adverse event rate was lower in the intervention group (8.33% vs. 29.17%, p = 0.019), although individual event types showed no statistically significant difference.
Conclusion: Acupoint-embedded needling combined with auricular acupressure is an effective and well-tolerated approach for managing simple obesity associated with spleen deficiency and dampness, with benefits in weight loss, improved metabolism, and symptom relief.
DOI: 10.6084/m9.figshare.30050953.v1
title: Supplementary Material for: Combination Therapy for Simple Obesity: Acupoint Needling and Auricular Acupressure Effects

description: Introduction: To evaluate the efficacy and safety of acupoint-embedded needling combined with auricular acupressure in treating simple obesity associated with spleen deficiency and dampness accumulation.
Methods: Ninety-six patients with simple obesity were randomized into two groups. The intervention group received acupoint-embedded needling and auricular acupressure, while the control group received conventional acupuncture. After 30 days, body weight, body mass index (BMI), waist circumference, blood lipid profiles, traditional Chinese medicine (TCM) syndrome scores, and metabolic markers were assessed. These included homeostasis model assessment of insulin resistance (HOMA-IR), serum leptin, high-sensitivity C-reactive protein (hs-CRP), body fat percentage, and basal metabolic rate (BMR). Adverse events were monitored.
Results: Compared to the control group, the intervention group showed significantly greater reductions in body weight, BMI, waist circumference, total cholesterol, triglycerides, and low-density lipoprotein cholesterol, as well as increases in high-density lipoprotein cholesterol (all p &lt; 0.05). TCM scores and metabolic indicators also showed significant improvement. The overall adverse event rate was lower in the intervention group (8.33% vs. 29.17%, p = 0.019), although individual event types showed no statistically significant difference.
Conclusion: Acupoint-embedded needling combined with auricular acupressure is an effective and well-tolerated approach for managing simple obesity associated with spleen deficiency and dampness, with benefits in weight loss, improved metabolism, and symptom relief.
DOI: 10.6084/m9.figshare.30050962
title: Supplementary Material for: Alcohol-Related and Non-Alcohol-Related Wernicke Encephalopathy: A Systematic Review and Meta-Analysis of Epidemiology and Clinical Features.

description: Introduction
To characterize the epidemiology, risk factors, and clinical presentation of Wernicke encephalopathy (WE), and analyze differences between cases with and without excessive alcohol consumption.
Methods
A systematic search was conducted in PubMed, Scopus, and Web of Science up to April 1st, 2025. The included studies provided data on prevalence, risk factors, clinical and radiological findings, mortality, and prognosis in patients with WE. Pooled proportions and weighted means were calculated using random-effect models with Freeman–Tukey transformation. Heterogeneity was assessed using the I² statistic. Subgroup comparisons were performed based on the presence or absence of excessive alcohol consumption.
Results
A total of 12 studies comprising 5,510 patients were analyzed. Overall, 65.4% (95% CI: 56.0–74.2) were male, with a weighted mean age of 60.7 years. Among cases related to excessive alcohol consumption, 78.7% were male (mean age 55.2); in cases not related to such consumption, 52.6% were male (mean age 63.5). The classic triad was present in 32.7% of cases (95% CI: 19.2–47.7). Among patients evaluated by magnetic resonance imaging, typical lesions were identified in 82.0%, and atypical lesions in 44.8%. Overall mortality was 5.1% (95% CI: 2.3–8.8%) and higher in non-alcohol-related cases (8.8%). Alcohol consumption was the main risk factor (90.7%); among non-alcohol-related cases, the most frequent clinical settings were malnutrition (30.2%), infections (25.1%), and psychiatric disorders (15.4%). 
Conclusions
WE is a multifactorial syndrome that extends beyond alcohol misuse, with wide clinical and pathophysiological variability. These findings underscore the importance of early recognition and prompt thiamine replacement, particularly in non-alcohol-related cases.
DOI: 10.6084/m9.figshare.30050962.v1
title: Supplementary Material for: Alcohol-Related and Non-Alcohol-Related Wernicke Encephalopathy: A Systematic Review and Meta-Analysis of Epidemiology and Clinical Features.

description: Introduction
To characterize the epidemiology, risk factors, and clinical presentation of Wernicke encephalopathy (WE), and analyze differences between cases with and without excessive alcohol consumption.
Methods
A systematic search was conducted in PubMed, Scopus, and Web of Science up to April 1st, 2025. The included studies provided data on prevalence, risk factors, clinical and radiological findings, mortality, and prognosis in patients with WE. Pooled proportions and weighted means were calculated using random-effect models with Freeman–Tukey transformation. Heterogeneity was assessed using the I² statistic. Subgroup comparisons were performed based on the presence or absence of excessive alcohol consumption.
Results
A total of 12 studies comprising 5,510 patients were analyzed. Overall, 65.4% (95% CI: 56.0–74.2) were male, with a weighted mean age of 60.7 years. Among cases related to excessive alcohol consumption, 78.7% were male (mean age 55.2); in cases not related to such consumption, 52.6% were male (mean age 63.5). The classic triad was present in 32.7% of cases (95% CI: 19.2–47.7). Among patients evaluated by magnetic resonance imaging, typical lesions were identified in 82.0%, and atypical lesions in 44.8%. Overall mortality was 5.1% (95% CI: 2.3–8.8%) and higher in non-alcohol-related cases (8.8%). Alcohol consumption was the main risk factor (90.7%); among non-alcohol-related cases, the most frequent clinical settings were malnutrition (30.2%), infections (25.1%), and psychiatric disorders (15.4%). 
Conclusions
WE is a multifactorial syndrome that extends beyond alcohol misuse, with wide clinical and pathophysiological variability. These findings underscore the importance of early recognition and prompt thiamine replacement, particularly in non-alcohol-related cases.
DOI: 10.6084/m9.figshare.30050965
title: Supplementary Material for: Structured magnetic resonance imaging assessment improves diagnosis of pathological complete response in rectal cancer after neoadjuvant chemoradiation

description: Introduction: Precise prediction of pathological complete response (pCR) following neoadjuvant chemoradiotherapy (nCRT) in rectal cancer may identify candidates for non-operative management. The optimal selection of diagnostic tools is therefore of major clinical importance.
Methods: Clinical, laboratory, endoscopic and radiological data of patients with rectal cancer treated with nCRT and surgery at an academic medical center from 2010 to 2020 were retrospectively collected. Pre- and post-nCRT magnetic resonance imaging (MRI) was reviewed with a structured report template and assessed by magnetic resonance imaging tumor regression grade (mrTRG). Two senior radiologists reviewed mrTRG independently to determine the inter-reader agreement. Univariate logistic regression was applied to identify parameters that predict pCR. A multivariate prediction model was developed using L1-penalized logistic regression, with performance assessed by area under the curve (AUC) in the total cohort (apparent AUC) and by cross validation (CV-AUC).
Results: A total of 261 patients were identified, of whom 36 achieved pCR. Univariate analysis showed a significant correlation between post-nCRT features with pCR, including radiological T-stage (OR 0.05 [0.02-0.15], p&lt;0.001), mrTRG (OR 0.13 [0.05-0.31], p&lt;0.001) and endoscopic response (OR 0.17 [0.05-0.54], p=0.032). Of those, mrTRG showed the highest AUC of 0.77 with a substantial inter-reader agreement (kappa=0.71, 95% CI: 0.61 to 0.81). The multivariate predictive model selected eight pre- and post-nCRT parameters with apparent AUC of 0.84 and CV-AUC of 0.73. 
Conclusion: Therapy response assessed by MRI, particularly by mrTRG, strongly predicted pCR. Therefore, mrTRG should be implemented in routine assessment of rectal cancer treated by nCRT.
DOI: 10.6084/m9.figshare.30050965.v1
title: Supplementary Material for: Structured magnetic resonance imaging assessment improves diagnosis of pathological complete response in rectal cancer after neoadjuvant chemoradiation

description: Introduction: Precise prediction of pathological complete response (pCR) following neoadjuvant chemoradiotherapy (nCRT) in rectal cancer may identify candidates for non-operative management. The optimal selection of diagnostic tools is therefore of major clinical importance.
Methods: Clinical, laboratory, endoscopic and radiological data of patients with rectal cancer treated with nCRT and surgery at an academic medical center from 2010 to 2020 were retrospectively collected. Pre- and post-nCRT magnetic resonance imaging (MRI) was reviewed with a structured report template and assessed by magnetic resonance imaging tumor regression grade (mrTRG). Two senior radiologists reviewed mrTRG independently to determine the inter-reader agreement. Univariate logistic regression was applied to identify parameters that predict pCR. A multivariate prediction model was developed using L1-penalized logistic regression, with performance assessed by area under the curve (AUC) in the total cohort (apparent AUC) and by cross validation (CV-AUC).
Results: A total of 261 patients were identified, of whom 36 achieved pCR. Univariate analysis showed a significant correlation between post-nCRT features with pCR, including radiological T-stage (OR 0.05 [0.02-0.15], p&lt;0.001), mrTRG (OR 0.13 [0.05-0.31], p&lt;0.001) and endoscopic response (OR 0.17 [0.05-0.54], p=0.032). Of those, mrTRG showed the highest AUC of 0.77 with a substantial inter-reader agreement (kappa=0.71, 95% CI: 0.61 to 0.81). The multivariate predictive model selected eight pre- and post-nCRT parameters with apparent AUC of 0.84 and CV-AUC of 0.73. 
Conclusion: Therapy response assessed by MRI, particularly by mrTRG, strongly predicted pCR. Therefore, mrTRG should be implemented in routine assessment of rectal cancer treated by nCRT.
DOI: 10.6084/m9.figshare.30050968
title: Supplementary Material for: Insights into Silica-Induced Lung Fibrosis: Fibrotic Gene Signatures, Pathways, and Therapeutic Opportunities

description: Silica exposure is a significant environmental hazard linked to lung inflammation and fibrosis. This study utilized in-silico analysis of publicly available transcriptomic datasets (GSE250537 and GSE142446) from silica-exposed Fischer 344 rats to investigate molecular pathways and potential therapeutic targets. Rats were exposed to crystalline silica via inhalation, and transcriptomic data from lung and blood samples were analyzed at four post-exposure intervals (1-day, 3-month, 6-month, and 9-month). Gene set enrichment analysis (GSEA) revealed the activation of fibro-inflammatory and aging pathways in lung tissue, including TGF-beta, NLRP3, and TNF-α signaling, with limited effects in blood transcriptomes. Differential expression analysis identified 12 key fibrotic markers consistently upregulated in lung tissue, such as Cxcl6, Mmp12, and S100a9, which are involved in inflammation, tissue remodeling, and fibrosis. Temporal analysis indicated prolonged upregulation of fibrotic markers up to 9 months post-exposure. Protein-protein interaction networks highlighted clusters related to chemokine signaling, tissue remodeling, and matrix metalloproteinases. Using the open-TG gate database, 179 pharmacological agents were identified as potential treatments, with 37 targeting five or more fibrotic genes. Notable candidates include NSAIDs, captopril, and simvastatin, offering promising therapeutic avenues to mitigate silica-induced lung pathology. In vivo validation in a silica-induced murine fibrosis model further demonstrated that simvastatin treatment significantly reduced the expression of key fibro-inflammatory genes and attenuated the increase in fibrotic markers in lung tissue. These findings provide insights into silica immunopathology and potential drug repurposing strategies; however, further studies are warranted to elucidate underlying mechanisms and evaluate therapeutic efficacy in clinical settings.
DOI: 10.6084/m9.figshare.30050968.v1
title: Supplementary Material for: Insights into Silica-Induced Lung Fibrosis: Fibrotic Gene Signatures, Pathways, and Therapeutic Opportunities

description: Silica exposure is a significant environmental hazard linked to lung inflammation and fibrosis. This study utilized in-silico analysis of publicly available transcriptomic datasets (GSE250537 and GSE142446) from silica-exposed Fischer 344 rats to investigate molecular pathways and potential therapeutic targets. Rats were exposed to crystalline silica via inhalation, and transcriptomic data from lung and blood samples were analyzed at four post-exposure intervals (1-day, 3-month, 6-month, and 9-month). Gene set enrichment analysis (GSEA) revealed the activation of fibro-inflammatory and aging pathways in lung tissue, including TGF-beta, NLRP3, and TNF-α signaling, with limited effects in blood transcriptomes. Differential expression analysis identified 12 key fibrotic markers consistently upregulated in lung tissue, such as Cxcl6, Mmp12, and S100a9, which are involved in inflammation, tissue remodeling, and fibrosis. Temporal analysis indicated prolonged upregulation of fibrotic markers up to 9 months post-exposure. Protein-protein interaction networks highlighted clusters related to chemokine signaling, tissue remodeling, and matrix metalloproteinases. Using the open-TG gate database, 179 pharmacological agents were identified as potential treatments, with 37 targeting five or more fibrotic genes. Notable candidates include NSAIDs, captopril, and simvastatin, offering promising therapeutic avenues to mitigate silica-induced lung pathology. In vivo validation in a silica-induced murine fibrosis model further demonstrated that simvastatin treatment significantly reduced the expression of key fibro-inflammatory genes and attenuated the increase in fibrotic markers in lung tissue. These findings provide insights into silica immunopathology and potential drug repurposing strategies; however, further studies are warranted to elucidate underlying mechanisms and evaluate therapeutic efficacy in clinical settings.
DOI: 10.6084/m9.figshare.30050971
title: Supplementary Material for: Extraction of Magnetic Intraocular Foreign Bodies Using a Novel Magnetic Foreign Body Extractor: Two Cases

description: Abstract
Purpose：The extraction of intraocular foreign bodies (IOFB) presents a significant challenge in ocular surgery.This report introduces a novel magnetic foreign body extractor specifically designed for the removal of small to medium-sized magnetic IOFBs located in the posterior segment of the eye.
Case Presentation: our report presents two cases of IOFB removal using a novel magnetic foreign body extractor, performed in conjunction with pars plana vitrectomy (PPV). The IOFBs were successfully removed through corneal or limbal incisions with a 23-gauge rechargeable magnetic foreign body extractor, without the need to enlarge the scleral incision. 
Results: All procedures, were completed independently, without the use of additional instruments, resulting in no instances of iatrogenic retinal injury, vitreous incarceration, or postoperative proliferative vitreoretinopathy (PVR). Furthermore, both patients showed significant visual improvement, with best-corrected visual acuity (BCVA) improving from counting fingers preoperatively to 0.6 and 0.7 at the 1-month follow-up. 
Conclusions: The rechargeable magnetic foreign body extractor, in combination with minimally invasive vitrectomy techniques, offers a safe and effective solution for the removal of magnetic IOFBs in the posterior segment of the eye. This approach not only enhances visual acuity but also reduces the risk of postoperative complications, highlighting its potential as a valuable tool in ocular trauma management.
DOI: 10.6084/m9.figshare.30050971.v1
title: Supplementary Material for: Extraction of Magnetic Intraocular Foreign Bodies Using a Novel Magnetic Foreign Body Extractor: Two Cases

description: Abstract
Purpose：The extraction of intraocular foreign bodies (IOFB) presents a significant challenge in ocular surgery.This report introduces a novel magnetic foreign body extractor specifically designed for the removal of small to medium-sized magnetic IOFBs located in the posterior segment of the eye.
Case Presentation: our report presents two cases of IOFB removal using a novel magnetic foreign body extractor, performed in conjunction with pars plana vitrectomy (PPV). The IOFBs were successfully removed through corneal or limbal incisions with a 23-gauge rechargeable magnetic foreign body extractor, without the need to enlarge the scleral incision. 
Results: All procedures, were completed independently, without the use of additional instruments, resulting in no instances of iatrogenic retinal injury, vitreous incarceration, or postoperative proliferative vitreoretinopathy (PVR). Furthermore, both patients showed significant visual improvement, with best-corrected visual acuity (BCVA) improving from counting fingers preoperatively to 0.6 and 0.7 at the 1-month follow-up. 
Conclusions: The rechargeable magnetic foreign body extractor, in combination with minimally invasive vitrectomy techniques, offers a safe and effective solution for the removal of magnetic IOFBs in the posterior segment of the eye. This approach not only enhances visual acuity but also reduces the risk of postoperative complications, highlighting its potential as a valuable tool in ocular trauma management.