cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10259555
title: Eveningness and poor sleep quality contribute to depressive residual symptoms and behavioral inhibition in patients with bipolar disorder

description: Eveningness and sleep disturbances are considered as markers of Bipolar Disorder (BD) and influence mood and emotional or behavioral states. This study investigates the associations between circadian markers and sleep quality on residual depressive symptoms and inhibition/activation dimensions during the euthymic phase. A sample of 89 euthymic adult individuals with BD was assessed for circadian preference and typology using the Composite Scale of Morningness (CSM) and the Circadian Type Inventory (CTI) and for sleep quality using the Pittsburgh Sleep Quality Index (PSQI). The Montgomery and Asberg Depression Rating Scale (MADRS) and the Multidimensional Assessment of Thymic States (MAThyS) were used to measure residual depressive symptoms and the inhibition/activation dimensions. We examined any associations between these parameters using correlations and path analyses. We identified significant associations between eveningness and poorer sleep quality that correlated to higher depressive residual symptoms and a global inhibition. The use of path analyses led us to conclude that poor sleep quality mediated the relationship between eveningness and either residual mood symptoms or behavioral inhibition (motivation, sensory perception, interpersonal interaction, and cognition). These factors should be considered in the clinical evaluation of individuals with BD, with a specific attention during the euthymic phase, in order to achieve the best functional outcome possible.
DOI: 10.6084/m9.figshare.10271486.v2
title: Evening chronotype, late weekend sleep times and social jetlag as possible causes of sleep curtailment after maintaining perennial DST: ain’t they as black as they are painted?

description: People sleep less in response to setting social clocks earlier relative to the sun clocks. We proposed here a model-based approach for estimating sleep loss as the difference between weekend and weekday risetimes divided on the difference between weekend risetime and weekday bedtime. We compared this approach with a traditional approach to estimating sleep curtailment as the difference in weekly average sleep duration in two conditions. Weekday and weekend sleep times reported for 320 samples provided possibility of testing whether evening types with later weekend sleep times and larger social jetlag differ from morning types with earlier weekend sleep times and smaller social jetlag on amount of sleep lost (1) throughout the week and (2) in response to an advance of weekday wakeups, for instance, after the expected installation of perennial Daylight Saving Time (DST). We found that (1) an amount of sleep lost due to advancing shift of weekday wakeups depends upon neither chronotype nor weekend sleep times nor social jetlag, (2) a very large amount of sleep is usually lost by evening types with later weekend sleep times and larger social jetlag and (3) an essential sleep loss is caused by our usual work/school schedules, even in morning types with early weekend sleep times and small social jetlag. As compared to such permanent sleep losses experienced by any types, an additional loss due to switching from Standard Time (ST) to perennial DST are expected to be relatively small. We also found that the traditional way of calculation of sleep curtailment leads to paradoxical conclusions, such as (1) sleep loss is larger when social jetlag is smaller, not larger, (2) sleep loss is larger when weekend sleep times are earlier, not later, (3) despite 1-h difference between two student samples in weekday wakeups, their sleep losses can be identical.
DOI: 10.6084/m9.figshare.10259555.v1
title: Eveningness and poor sleep quality contribute to depressive residual symptoms and behavioral inhibition in patients with bipolar disorder

description: Eveningness and sleep disturbances are considered as markers of Bipolar Disorder (BD) and influence mood and emotional or behavioral states. This study investigates the associations between circadian markers and sleep quality on residual depressive symptoms and inhibition/activation dimensions during the euthymic phase. A sample of 89 euthymic adult individuals with BD was assessed for circadian preference and typology using the Composite Scale of Morningness (CSM) and the Circadian Type Inventory (CTI) and for sleep quality using the Pittsburgh Sleep Quality Index (PSQI). The Montgomery and Asberg Depression Rating Scale (MADRS) and the Multidimensional Assessment of Thymic States (MAThyS) were used to measure residual depressive symptoms and the inhibition/activation dimensions. We examined any associations between these parameters using correlations and path analyses. We identified significant associations between eveningness and poorer sleep quality that correlated to higher depressive residual symptoms and a global inhibition. The use of path analyses led us to conclude that poor sleep quality mediated the relationship between eveningness and either residual mood symptoms or behavioral inhibition (motivation, sensory perception, interpersonal interaction, and cognition). These factors should be considered in the clinical evaluation of individuals with BD, with a specific attention during the euthymic phase, in order to achieve the best functional outcome possible.
DOI: 10.6084/m9.figshare.10271486
title: Evening chronotype, late weekend sleep times and social jetlag as possible causes of sleep curtailment after maintaining perennial DST: ain’t they as black as they are painted?

description: People sleep less in response to setting social clocks earlier relative to the sun clocks. We proposed here a model-based approach for estimating sleep loss as the difference between weekend and weekday risetimes divided on the difference between weekend risetime and weekday bedtime. We compared this approach with a traditional approach to estimating sleep curtailment as the difference in weekly average sleep duration in two conditions. Weekday and weekend sleep times reported for 320 samples provided possibility of testing whether evening types with later weekend sleep times and larger social jetlag differ from morning types with earlier weekend sleep times and smaller social jetlag on amount of sleep lost (1) throughout the week and (2) in response to an advance of weekday wakeups, for instance, after the expected installation of perennial Daylight Saving Time (DST). We found that (1) an amount of sleep lost due to advancing shift of weekday wakeups depends upon neither chronotype nor weekend sleep times nor social jetlag, (2) a very large amount of sleep is usually lost by evening types with later weekend sleep times and larger social jetlag and (3) an essential sleep loss is caused by our usual work/school schedules, even in morning types with early weekend sleep times and small social jetlag. As compared to such permanent sleep losses experienced by any types, an additional loss due to switching from Standard Time (ST) to perennial DST are expected to be relatively small. We also found that the traditional way of calculation of sleep curtailment leads to paradoxical conclusions, such as (1) sleep loss is larger when social jetlag is smaller, not larger, (2) sleep loss is larger when weekend sleep times are earlier, not later, (3) despite 1-h difference between two student samples in weekday wakeups, their sleep losses can be identical.
DOI: 10.6084/m9.figshare.10271486.v1
title: Evening chronotype, late weekend sleep times and social jetlag as possible causes of sleep curtailment after maintaining perennial DST: ain’t they as black as they are painted?

description: People sleep less in response to setting social clocks earlier relative to the sun clocks. We proposed here a model-based approach for estimating sleep loss as the difference between weekend and weekday risetimes divided on the difference between weekend risetime and weekday bedtime. We compared this approach with a traditional approach to estimating sleep curtailment as the difference in weekly average sleep duration in two conditions. Weekday and weekend sleep times reported for 320 samples provided possibility of testing whether evening types with later weekend sleep times and larger social jetlag differ from morning types with earlier weekend sleep times and smaller social jetlag on amount of sleep lost (1) throughout the week and (2) in response to an advance of weekday wakeups, for instance, after the expected installation of perennial Daylight Saving Time (DST). We found that (1) an amount of sleep lost due to advancing shift of weekday wakeups depends upon neither chronotype nor weekend sleep times nor social jetlag, (2) a very large amount of sleep is usually lost by evening types with later weekend sleep times and larger social jetlag and (3) an essential sleep loss is caused by our usual work/school schedules, even in morning types with early weekend sleep times and small social jetlag. As compared to such permanent sleep losses experienced by any types, an additional loss due to switching from Standard Time (ST) to perennial DST are expected to be relatively small. We also found that the traditional way of calculation of sleep curtailment leads to paradoxical conclusions, such as (1) sleep loss is larger when social jetlag is smaller, not larger, (2) sleep loss is larger when weekend sleep times are earlier, not later, (3) despite 1-h difference between two student samples in weekday wakeups, their sleep losses can be identical.
DOI: 10.6084/m9.figshare.11559120
title: Elucidating the aryl hydrocarbon receptor antagonism from a chemical-structural perspective

description: The aryl hydrocarbon receptor (AhR) plays an important role in several biological processes such as reproduction, immunity and homoeostasis. However, little is known on the chemical-structural and physicochemical features that influence the activity of AhR antagonistic modulators. In the present report, in vitro AhR antagonistic activity evaluations, based on a chemical-activated luciferase gene expression (AhR-CALUX) bioassay, and an extensive literature review were performed with the aim of constructing a structurally diverse database of contaminants and potentially toxic chemicals. Subsequently, QSAR models based on Linear Discriminant Analysis and Logistic Regression, as well as two toxicophoric hypotheses were proposed to model the AhR antagonistic activity of the built dataset. The QSAR models were rigorously validated yielding satisfactory performance for all classification parameters. Likewise, the toxicophoric hypotheses were validated using a diverse set of 350 decoys, demonstrating adequate robustness and predictive power. Chemical interpretations of both the QSAR and toxicophoric models suggested that hydrophobic constraints, the presence of aromatic rings and electron-acceptor moieties are critical for the AhR antagonism. Therefore, it is hoped that the deductions obtained in the present study will contribute to elucidate further on the structural and physicochemical factors influencing the AhR antagonistic activity of chemical compounds.
DOI: 10.6084/m9.figshare.11559120.v1
title: Elucidating the aryl hydrocarbon receptor antagonism from a chemical-structural perspective

description: The aryl hydrocarbon receptor (AhR) plays an important role in several biological processes such as reproduction, immunity and homoeostasis. However, little is known on the chemical-structural and physicochemical features that influence the activity of AhR antagonistic modulators. In the present report, in vitro AhR antagonistic activity evaluations, based on a chemical-activated luciferase gene expression (AhR-CALUX) bioassay, and an extensive literature review were performed with the aim of constructing a structurally diverse database of contaminants and potentially toxic chemicals. Subsequently, QSAR models based on Linear Discriminant Analysis and Logistic Regression, as well as two toxicophoric hypotheses were proposed to model the AhR antagonistic activity of the built dataset. The QSAR models were rigorously validated yielding satisfactory performance for all classification parameters. Likewise, the toxicophoric hypotheses were validated using a diverse set of 350 decoys, demonstrating adequate robustness and predictive power. Chemical interpretations of both the QSAR and toxicophoric models suggested that hydrophobic constraints, the presence of aromatic rings and electron-acceptor moieties are critical for the AhR antagonism. Therefore, it is hoped that the deductions obtained in the present study will contribute to elucidate further on the structural and physicochemical factors influencing the AhR antagonistic activity of chemical compounds.
DOI: 10.5517/ccdc.csd.cc25s7gp
title: CCDC 2019292: Experimental Crystal Structure Determination

description: Related Article: Wenyan Wang, Natalya V. Izarova, Jan van Leusen, Paul Kögerler|2020|Chem.Commun.|56|14857|doi:10.1039/D0CC05791F
DOI: 10.5517/ccdc.csd.cc25s7hq
title: CCDC 2019293: Experimental Crystal Structure Determination

description: Related Article: Wenyan Wang, Natalya V. Izarova, Jan van Leusen, Paul Kögerler|2020|Chem.Commun.|56|14857|doi:10.1039/D0CC05791F
DOI: 10.5517/ccdc.csd.cc22821h
title: CCDC 1914375: Experimental Crystal Structure Determination

description: Related Article: Andreas Eitzinger, Jean-François Brière, Dominique Cahard, Mario Waser|2020|Org.Biomol.Chem.|18|405|doi:10.1039/C9OB02666E
DOI: 10.5517/ccdc.csd.cc20dq8f
title: CCDC 1859264: Experimental Crystal Structure Determination

description: Related Article: Fernando Machado dos Santos, Meiry Edivirges Alvarenga, Ana Karoline Silva Mendanha Valdo, Renato Rabelo, Danielle Cangussu de Castro Gomes, Ângelo de Fátima, Thiago Vinicius Costa Lara, Cleiton Moreira da Silva, Thiago Teixeira Tasso, João Honorato Araujo Neto, Alzir Azevedo Batista, Alejandro Pedro Ayala, Javier Alcides Ellena, Vinicius Ferraz Guimarães, Cecília Maria Alves Oliveira, Lidya Cardozo da Silva, Boniek Gontijo Vaz, Felipe Terra Martins|2020|Chem.Commun.|56|15024|doi:10.1039/D0CC07043B
DOI: 10.5517/ccdc.csd.cc254pmn
title: CCDC 2000511: Experimental Crystal Structure Determination

description: Related Article: Fernando Machado dos Santos, Meiry Edivirges Alvarenga, Ana Karoline Silva Mendanha Valdo, Renato Rabelo, Danielle Cangussu de Castro Gomes, Ângelo de Fátima, Thiago Vinicius Costa Lara, Cleiton Moreira da Silva, Thiago Teixeira Tasso, João Honorato Araujo Neto, Alzir Azevedo Batista, Alejandro Pedro Ayala, Javier Alcides Ellena, Vinicius Ferraz Guimarães, Cecília Maria Alves Oliveira, Lidya Cardozo da Silva, Boniek Gontijo Vaz, Felipe Terra Martins|2020|Chem.Commun.|56|15024|doi:10.1039/D0CC07043B
DOI: 10.5517/ccdc.csd.cc254pnp
title: CCDC 2000512: Experimental Crystal Structure Determination

description: Related Article: Fernando Machado dos Santos, Meiry Edivirges Alvarenga, Ana Karoline Silva Mendanha Valdo, Renato Rabelo, Danielle Cangussu de Castro Gomes, Ângelo de Fátima, Thiago Vinicius Costa Lara, Cleiton Moreira da Silva, Thiago Teixeira Tasso, João Honorato Araujo Neto, Alzir Azevedo Batista, Alejandro Pedro Ayala, Javier Alcides Ellena, Vinicius Ferraz Guimarães, Cecília Maria Alves Oliveira, Lidya Cardozo da Silva, Boniek Gontijo Vaz, Felipe Terra Martins|2020|Chem.Commun.|56|15024|doi:10.1039/D0CC07043B
DOI: 10.17632/zdn8bvxjs3.1
title: Experimentation for paper "RóMULO: A Clustering Proposalin the Context of Data Lakes"

description: This package provides the software and the data required to perform the experimentation that accompanies the following article: RóMULO: A Clustering Proposal in the Context of Data Lakes By Patricia Jiménez, Juan C. Roldán, Rafael Corchuelo Submitted to journal Big Data Research
DOI: 10.5281/zenodo.3928078
title: R code and data to reproduce figures from the "Multivariate autoregressive modelling and conditional simulation for temporal uncertainty analysis of an urban water system in Luxembourg" paper

description: This repository contains the R code and data to reproduce figures from the "Multivariate autoregressive modelling and conditional simulation for temporal uncertainty analysis of an urban water system in Luxembourg" paper.
description: For updates please check https://github.com/ArturoTorres/temporal_uncertainty_paper_reproducible.git
DOI: 10.5281/zenodo.4399484
title: Repository of data supporting the thesis "Poly-algorithmic Techniques in Real Quantifier Elimination"

description: Dataset of various files (as a .zip) supporting the PhD thesis "Poly-algorithmic Techniques in Real Quantifier Elimination" by Zak Tonks, University of Bath. The PhD thesis is in the area of Quantifier Elimination over the Reals (QE) in Computer Algebra. The PhD thesis concerns implementation of algorithms in Quantifier Elimination, which largely culminates in the package QuantifierElimination for the Computer Algebra software Maple. Much of this repository is output of the benchmarking of this package against various other packes in Maple and otherwise. Otherwise there are some auxiliary tools and files to assist with working with QE in Maple, converting between various formats, and understanding case studies and the package QuantifierElimination via software demoes as Maple worksheets. An overview of the contents of this repository (as a .zip file, which contains subdirectories described in the README):<br> - The example databases contributed from the project, as files that can be read into Maple defining tables of examples, and associated functions to build or examine various examples,<br> - A pdf file providing the references for all examples from the example databases, and typesetting of the examples as associated QE problems,<br> - The benchmarking data produced from the benchmarking of the project as csv (comma separated value) files, and the Excel workbooks (xlsx files) processing said data into survival plots for the thesis,<br> - Copies of the survival plots themselves as .png files,<br> - The bash and Maple scripts used to generate the raw benchmarking data, that can be reused, including documentation how to do so in the associated README,<br> - Other auxiliary tools allowing for conversion of QE formulae between formats (such as that of SyNRAC, RegularChains, QuantifierElimination (amongst packages in Maple), and QEPCAD B.<br> - Maple worksheets and the associated exported pdf files used in software demos at conferences to demonstrate features of QuantifierElimination.<br> - Some pdf files demonstrating early case studies on Lazard curtains generated from an early development build of QuantifierElimination. Lastly, there is a README with more detail on the files of the repository further. To emulate the benchmarking of the thesis, an understanding of bash and potentially Maple is assumed, but the raw data from the project is provided here. Before QuantifierElimination's official release, the source code and/or Maple package as an .mla file is available for interested parties upon request to the author Zak Tonks (zak.p.tonks@bath.edu). Any other queries about this data or associated work should be directed to this email address. The author's PhD supervisor's email address is J.H.Davenport@bath.ac.uk.
description: {"references": ["Z. Tonks. Poly-algorithmic Techniques in Real Quantifier Elimination. PhD Thesis, University of Bath, 2021."]}
DOI: 10.6084/m9.figshare.10316222
title: Brain microvascular pathology in Susac syndrome: an electron microscopic study of five cases

description: Susac syndrome is a rare, immune-mediated disease characterized by encephalopathy, branch retinal artery occlusion, and hearing loss. Herein, we describe the electron microscopic findings of three brain biopsies and two brain autopsies performed on five patients whose working clinical diagnosis was Susac syndrome. In all five cases, the key findings were basement membrane thickening and collagen deposition in the perivascular space involving small vessels and leading to thickening of vessel walls, narrowing, and vascular occlusion. These findings indicate that Susac syndrome is a microvascular disease. Mononuclear cells were present in the perivascular space, underlining the inflammatory nature of the pathology. Though nonspecific, the changes can be distinguished from genetic and acquired small vessel diseases. The encephalopathy of Susac syndrome overlaps clinically with degenerative and infectious conditions, and brain biopsy may be used for its diagnosis. Its vascular etiology may not be obvious on light microscopy, and electron microscopy is important for its confirmation.
DOI: 10.6084/m9.figshare.10316222.v1
title: Brain microvascular pathology in Susac syndrome: an electron microscopic study of five cases

description: Susac syndrome is a rare, immune-mediated disease characterized by encephalopathy, branch retinal artery occlusion, and hearing loss. Herein, we describe the electron microscopic findings of three brain biopsies and two brain autopsies performed on five patients whose working clinical diagnosis was Susac syndrome. In all five cases, the key findings were basement membrane thickening and collagen deposition in the perivascular space involving small vessels and leading to thickening of vessel walls, narrowing, and vascular occlusion. These findings indicate that Susac syndrome is a microvascular disease. Mononuclear cells were present in the perivascular space, underlining the inflammatory nature of the pathology. Though nonspecific, the changes can be distinguished from genetic and acquired small vessel diseases. The encephalopathy of Susac syndrome overlaps clinically with degenerative and infectious conditions, and brain biopsy may be used for its diagnosis. Its vascular etiology may not be obvious on light microscopy, and electron microscopy is important for its confirmation.
DOI: 10.5281/zenodo.4399469
title: Coping with Fibromyalgia during the COVID-19 pandemic: adjustment and wellbeing

description: <strong>Abstract</strong> <strong>Objective:</strong> Individuals with pre-existing health conditions may be experiencing particular distress under Covid-19 pandemic-related lifestyle restrictions. Fibromyalgia syndrome (FMS) is a chronic condition where symptoms are known to be exacerbated by stress. The present study examined wellbeing, perceived symptom change and coping in individuals with and without FMS during pandemic-related social lockdown in the UK. <strong>Design:</strong> Participants with a diagnosis of FMS (N = 390) and a general public sample with no FMS (N = 151) completed questionnaires at three time points. <strong>Main Outcome Measures:</strong> BBC Wellbeing Scale, Cognitive-Emotional Regulation Questionnaire measure of coping, perception of extent to which symptoms have worsened or improved over time. <strong>Results:</strong> Contrary to expectations, FMS participants reported improved symptoms and wellbeing over the study period. Non-FMS participants experienced worsening health symptoms and no change in wellbeing. Coping strategies involving positive reappraisal, refocussing and planning were positively associated with wellbeing in the FMS group, <strong>Conclusion:</strong> The unpredictable symptom profile in FMS, and the regular readjustment to coping this necessitates, may support a form of resilience which has been adaptive during the pandemic. The results have implications for supporting people with FMS, and potentially other chronic conditions, especially at times of stress.
DOI: 10.6084/m9.figshare.12318458.v4
title: Denitrifying phosphorus removal sludge treated by heavy metals

description: Raw data and source codes to reproduce the results in our paper entitled "Revealing taxon-specific heavy metal resistance mechanisms in denitrifying phosphorus removal sludge using genome-centric metaproteomics". Following the codes, readers can follow the metagenomic and metaproteomic pipelines used in this study.