cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1588737
title: The visual gamma response to faces reflects the presence of sensory evidence and not awareness of the stimulus

description: The accompanying data is the data for the study: Perry, G. (2016) 'The visual gamma response to faces reflects the presence of sensory evidence and not awareness of the stimulus', Royal Society Open Science. For methods used to collect the data see that publication. Behavioural data: threshold_data.csv - Data from the session in which individuals' psychmetric functions for face detection were acquired. Column 1 contains partcipant number. Colums 2-10 contain response rates to each level of phase scrambling (w). Data in each cell corresponds to the proprtion of times the participant responded that they saw face for the corresponding value of w. From the resulting function fits the values of w required for each participant to identify the face 0.5% (subthreshold), 50% (threshold) and 99.5% (suprathreshold) were derived and these are given in colums 11-13. response_data.csv - Response data from the MEG session. Column 1 contains partcipant number. Colums 2-7 give total number of trials that partcipants reported seeing ('seen') or not seeing ('unseen') a face in each of the three conditions. Colums 8-9 give the number of trials in each of the analysed sub-conditions ('subthreshold unseen', 'threshold unseen', 'threshold seen', 'suprathreshold seen') after trial exclusions. MEG data: virtual_sensor_coordinates.csv - Coordinates in Talairach space for the locations used for virtual sensor analysis (as well as group mean and standard deviation). Dashed cells correspond to individuals for which no location was found. gamma_amplitude.csv - Gamma amplitudes used in the main t-test analyses. Column 1 contains partcipant number. Columns 2-9 contains mean gamma amplitude for each participant by sub-condition and hemisphere. virtual_sensor_participant_x_y_z.csv contains the virtual sensor timeseries for participant x from trials in sub-condition y from hemsiphere z. Column one gives time (in ms relative to stimulus onset). Subsequenct columns give the virtual sensor data for each trial (trials containing artefacts have been removed). tf_participant_x_y_z.csv contains the time-frequency data for participant x from sub-condition y from hemsiphere z. Column 1 gives time relative to stimulus onset (in ms), row 1 gives frequency (in Hz), other columns/rows give data at the corresponding time and frequency as % amplitude relative to baseline.
DOI: 10.6084/m9.figshare.1588737.v1
title: The visual gamma response to faces reflects the presence of sensory evidence and not awareness of the stimulus

description: The accompanying data is the data for the study: Perry, G. (2016) 'The visual gamma response to faces reflects the presence of sensory evidence and not awareness of the stimulus', Royal Society Open Science. For methods used to collect the data see that publication. Behavioural data: threshold_data.csv - Data from the session in which individuals' psychmetric functions for face detection were acquired. Column 1 contains partcipant number. Colums 2-10 contain response rates to each level of phase scrambling (w). Data in each cell corresponds to the proprtion of times the participant responded that they saw face for the corresponding value of w. From the resulting function fits the values of w required for each participant to identify the face 0.5% (subthreshold), 50% (threshold) and 99.5% (suprathreshold) were derived and these are given in colums 11-13. response_data.csv - Response data from the MEG session. Column 1 contains partcipant number. Colums 2-7 give total number of trials that partcipants reported seeing ('seen') or not seeing ('unseen') a face in each of the three conditions. Colums 8-9 give the number of trials in each of the analysed sub-conditions ('subthreshold unseen', 'threshold unseen', 'threshold seen', 'suprathreshold seen') after trial exclusions. MEG data: virtual_sensor_coordinates.csv - Coordinates in Talairach space for the locations used for virtual sensor analysis (as well as group mean and standard deviation). Dashed cells correspond to individuals for which no location was found. gamma_amplitude.csv - Gamma amplitudes used in the main t-test analyses. Column 1 contains partcipant number. Columns 2-9 contains mean gamma amplitude for each participant by sub-condition and hemisphere. virtual_sensor_participant_x_y_z.csv contains the virtual sensor timeseries for participant x from trials in sub-condition y from hemsiphere z. Column one gives time (in ms relative to stimulus onset). Subsequenct columns give the virtual sensor data for each trial (trials containing artefacts have been removed). tf_participant_x_y_z.csv contains the time-frequency data for participant x from sub-condition y from hemsiphere z. Column 1 gives time relative to stimulus onset (in ms), row 1 gives frequency (in Hz), other columns/rows give data at the corresponding time and frequency as % amplitude relative to baseline.
DOI: 10.6084/m9.figshare.1588578
title: Flashing light enhancement of photosynthesis and growth occurs when photochemistry and photoprotection are balanced in <i>Dunaliella salina</i>

description: Photosynthesis and growth in <i>Dunaliella salina</i> were significantly (P ≤ 0.01) enhanced under flashing light with a light–dark cycle tailored for the minimal activation of the violaxanthin cycle (VC), in comparison with cultures grown under constant illumination of the same time-integrated photon dose. The experiments were performed without using inhibitors or any other experimental conditions other than light. The flashing light (FL) was optimally balanced for the growth and photosynthesis of <i>D. salina</i>, which was characterized by a decreased VC de-epoxidation rate. The high-light induction of non-photochemical quenching (NPQ) was significantly slower in the FL-acclimated cells compared with those acclimated to continuous illumination. The comparative investigation of the cell ultrastructure revealed distinct effects of high-light stress in cultures grown under continuous light; this was not the case under FL. We conclude that a slower activation of the VC takes place under balanced flashing light, when each flash is followed by a dark period long enough for utilization of the photons absorbed during the flash at a given irradiance. The activation kinetics of the VC and, hence, the induction of NPQ seem to play an important role in the enhancement of the photosynthesis observed in <i>D. salina</i> grown under flashing light. Potential use of these parameters for optimization of FL for microalgal cultivation is discussed.
DOI: 10.6084/m9.figshare.1588583.v2
title: Longitudinal observations of typical English voicing acquisition in a 2-year-old child: Stability of the contrast and considerations for clinical assessment

description: Early assessment of phonetic and phonological development requires knowledge of typical versus atypical speech patterns, as well as the range of individual developmental trajectories. The nature of data reporting in previous literature on typical voicing acquisition left aspects of the developmental process unclear and limited clinical applicability. This work extends a previous four-month group study to present data for one child over 12 months. Words containing initial /b p d t/ were elicited from a monolingual English-speaking 2-year-old child biweekly for 25 sessions. Voice onset time (VOT) was measured for each stop. For each consonant and recording session, we measured range as well as accuracy, overshoot and discreteness calculated for means and individual tokens. The results underscore the value of token-by-token analyses. They further reveal that typical development may involve an extended period of fluctuating voicing patterns, suggesting that the voiced/voiceless contrast may take months or years to stabilise.
DOI: 10.6084/m9.figshare.1588583.v1
title: Longitudinal observations of typical English voicing acquisition in a 2-year-old child: Stability of the contrast and considerations for clinical assessment

description: Early assessment of phonetic and phonological development requires knowledge of typical versus atypical speech patterns, as well as the range of individual developmental trajectories. The nature of data reporting in previous literature on typical voicing acquisition left aspects of the developmental process unclear and limited clinical applicability. This work extends a previous four-month group study to present data for one child over 12 months. Words containing initial /b p d t/ were elicited from a monolingual English-speaking 2-year-old child biweekly for 25 sessions. Voice onset time (VOT) was measured for each stop. For each consonant and recording session, we measured range as well as accuracy, overshoot and discreteness calculated for means and individual tokens. The results underscore the value of token-by-token analyses. They further reveal that typical development may involve an extended period of fluctuating voicing patterns, suggesting that the voiced/voiceless contrast may take months or years to stabilise.
DOI: 10.6084/m9.figshare.1588578.v1
title: Flashing light enhancement of photosynthesis and growth occurs when photochemistry and photoprotection are balanced in <i>Dunaliella salina</i>

description: Photosynthesis and growth in <i>Dunaliella salina</i> were significantly (P ≤ 0.01) enhanced under flashing light with a light–dark cycle tailored for the minimal activation of the violaxanthin cycle (VC), in comparison with cultures grown under constant illumination of the same time-integrated photon dose. The experiments were performed without using inhibitors or any other experimental conditions other than light. The flashing light (FL) was optimally balanced for the growth and photosynthesis of <i>D. salina</i>, which was characterized by a decreased VC de-epoxidation rate. The high-light induction of non-photochemical quenching (NPQ) was significantly slower in the FL-acclimated cells compared with those acclimated to continuous illumination. The comparative investigation of the cell ultrastructure revealed distinct effects of high-light stress in cultures grown under continuous light; this was not the case under FL. We conclude that a slower activation of the VC takes place under balanced flashing light, when each flash is followed by a dark period long enough for utilization of the photons absorbed during the flash at a given irradiance. The activation kinetics of the VC and, hence, the induction of NPQ seem to play an important role in the enhancement of the photosynthesis observed in <i>D. salina</i> grown under flashing light. Potential use of these parameters for optimization of FL for microalgal cultivation is discussed.
DOI: 10.6084/m9.figshare.1588573
title: Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review

description: <i>Background</i>: Cadmium (Cd) is abundantly documented as a metal mainly affecting tubular function both in workers and in the general population indirectly exposed via the environment. Results from epidemiological studies linking Cd exposure and risk of progression to chronic kidney disease (CKD) are, however, conflicting. <i>Objectives</i>: To perform a systematic review of the association between Cd exposure and CKD. <i>Methods</i>: A systematic appraisal of publications found in MEDLINE (1946–2014), EMBASE (1974–2012) and an in-house database (1986–2013) was conducted. Additional studies were searched for by contacting experts and checking reference lists. Search terms used key and text words. No language restriction was applied. Cohort, case–control and case-series with follow-up including individual and objective assessment of occupational or environmental exposure were eligible. Studies were selected and data extracted by two independent reviewers using predefined forms. Study characteristics and results were extracted to structured tables. Synthesis was qualitative and results appraised with causality criteria. <i>Results:</i> Thirty-four exposed groups, totaling more than 3000 participants, were eligible. Overall, results disclosed no convincing evidence supporting a risk of progression to CKD in populations exposed to Cd. Lack of information about methods, risk of bias and heterogeneity were identified as limitations and precluded conducting a meta-analysis. Publication bias did not appear as a major problem. <i>Conclusions</i>: This qualitative systematic review does not support the contention that human exposure to Cd leads to progressive CKD.
DOI: 10.6084/m9.figshare.1588567
title: A New Mo(VI) Complex of (E)-2-(((5-hydroxypentyl)imino)methyl)-6-methoxyphenol: Synthesis, Characterization, and X-Ray Crystal Structure

description: A tridentate ONO Schiff base ligand, (E)-2-(((5-hydroxypentyl)imino)methyl)-6-methoxyphenol [H<sub>2</sub>L], and its Mo(VI) complex [MoL], have been synthesized and structurally characterized by elemental analysis, FT-IR, NMR, and UV–Vis spectroscopy. The structure of the Mo(VI) complex has been determined by single-crystal X-ray diffraction. This complex has octahedral geometry around central atom. Yellow crystals crystallize in orthorhombic, space group <i>Pbca</i> with <i>a</i> = 17.8718(10) Å, <i>b</i> = 17.4516(10) Å, <i>c</i>, 18.1872(10) Å and α = β = γ = 90°.
DOI: 10.6084/m9.figshare.1588573.v1
title: Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review

description: <i>Background</i>: Cadmium (Cd) is abundantly documented as a metal mainly affecting tubular function both in workers and in the general population indirectly exposed via the environment. Results from epidemiological studies linking Cd exposure and risk of progression to chronic kidney disease (CKD) are, however, conflicting. <i>Objectives</i>: To perform a systematic review of the association between Cd exposure and CKD. <i>Methods</i>: A systematic appraisal of publications found in MEDLINE (1946–2014), EMBASE (1974–2012) and an in-house database (1986–2013) was conducted. Additional studies were searched for by contacting experts and checking reference lists. Search terms used key and text words. No language restriction was applied. Cohort, case–control and case-series with follow-up including individual and objective assessment of occupational or environmental exposure were eligible. Studies were selected and data extracted by two independent reviewers using predefined forms. Study characteristics and results were extracted to structured tables. Synthesis was qualitative and results appraised with causality criteria. <i>Results:</i> Thirty-four exposed groups, totaling more than 3000 participants, were eligible. Overall, results disclosed no convincing evidence supporting a risk of progression to CKD in populations exposed to Cd. Lack of information about methods, risk of bias and heterogeneity were identified as limitations and precluded conducting a meta-analysis. Publication bias did not appear as a major problem. <i>Conclusions</i>: This qualitative systematic review does not support the contention that human exposure to Cd leads to progressive CKD.
DOI: 10.6084/m9.figshare.1588564
title: Use of PBL in an organizational setting construction: discussion focusing on issues related to projects

description: The changes in the scenario of civil engineering and consequently the production management of the works require an engineer with a different player profile works, resulting in the need for more refined skills of these professionals, become indispensable dominance over innovation, customer focus, planning, knowledge of quality management systems, sustainability and a humanist vision. The main objective of this paper is to show the efficiency of the use of the methodology of Problem Based Learning adapted to the organizational context. The research strategy was adopted action research as it had teamwork and commitment to change on the part of those involved, for this research has focused on issues related to projects, supplies and human resources. Achievements involved the development related to the organizational context, the individual, collective and organizational learning skills, pointing out problems and possible solutions in the management company. Through the development of managerial skills, was stimulated a humanistic, sustainable vision, customer focus, and a better system of quality management. We identified problems in organizational management system, evidencing the need for creating an enabling environment for the exchange of information among its sectors.
DOI: 10.6084/m9.figshare.1588563
title: Post-Stroke Longitudinal Alterations of Inter-Hemispheric Correlation and Hemispheric Dominance in Mouse Pre-Motor Cortex

description: Limited restoration of function is known to occur spontaneously after an ischemic injury to the primary motor cortex. Evidence suggests that Pre-Motor Areas (PMAs) may “take over” control of the disrupted functions. However, little is known about functional reorganizations in PMAs. Forelimb movements in mice can be driven by two cortical regions, Caudal and Rostral Forelimb Areas (CFA and RFA), generally accepted as primary motor and pre-motor cortex, respectively. Here, we examined longitudinal changes in functional coupling between the two RFAs following unilateral photothrombotic stroke in CFA (mm from Bregma: +0.5 anterior, +1.25 lateral). Local field potentials (LFPs) were recorded from the RFAs of both hemispheres in freely moving injured and naïve mice. Neural signals were acquired at 9, 16 and 23 days after surgery (sub-acute period in stroke animals) through one bipolar electrode per hemisphere placed in the center of RFA, with a ground screw over the occipital bone. LFPs were pre-processed through an efficient method of artifact removal and analysed through: spectral, cross-correlation, mutual information and Granger causality analysis.Spectral analysis demonstrated an early decrease (day 9) in the alpha band power in both the RFAs. In the late sub-acute period (days 16 and 23), inter-hemispheric functional coupling was reduced in ischemic animals, as shown by a decrease in the cross-correlation and mutual information measures. Within the gamma and delta bands, correlation measures were already reduced at day 9. Granger analysis, used as a measure of the symmetry of the inter-hemispheric causal connectivity, showed a less balanced activity in the two RFAs after stroke, with more frequent oscillations of hemispheric dominance.These results indicate robust electrophysiological changes in PMAs after stroke. Specifically, we found alterations in transcallosal connectivity, with reduced inter-hemispheric functional coupling and a fluctuating dominance pattern. These reorganizations may underlie vicariation of lost functions following stroke.
DOI: 10.6084/m9.figshare.1588567.v2
title: A New Mo(VI) Complex of (E)-2-(((5-hydroxypentyl)imino)methyl)-6-methoxyphenol: Synthesis, Characterization, and X-Ray Crystal Structure

description: A tridentate ONO Schiff base ligand, (E)-2-(((5-hydroxypentyl)imino)methyl)-6-methoxyphenol [H<sub>2</sub>L], and its Mo(VI) complex [MoL], have been synthesized and structurally characterized by elemental analysis, FT-IR, NMR, and UV–Vis spectroscopy. The structure of the Mo(VI) complex has been determined by single-crystal X-ray diffraction. This complex has octahedral geometry around central atom. Yellow crystals crystallize in orthorhombic, space group <i>Pbca</i> with <i>a</i> = 17.8718(10) Å, <i>b</i> = 17.4516(10) Å, <i>c</i>, 18.1872(10) Å and α = β = γ = 90°.
DOI: 10.6084/m9.figshare.1588564.v1
title: Use of PBL in an organizational setting construction: discussion focusing on issues related to projects

description: The changes in the scenario of civil engineering and consequently the production management of the works require an engineer with a different player profile works, resulting in the need for more refined skills of these professionals, become indispensable dominance over innovation, customer focus, planning, knowledge of quality management systems, sustainability and a humanist vision. The main objective of this paper is to show the efficiency of the use of the methodology of Problem Based Learning adapted to the organizational context. The research strategy was adopted action research as it had teamwork and commitment to change on the part of those involved, for this research has focused on issues related to projects, supplies and human resources. Achievements involved the development related to the organizational context, the individual, collective and organizational learning skills, pointing out problems and possible solutions in the management company. Through the development of managerial skills, was stimulated a humanistic, sustainable vision, customer focus, and a better system of quality management. We identified problems in organizational management system, evidencing the need for creating an enabling environment for the exchange of information among its sectors.
DOI: 10.6084/m9.figshare.1588555
title: Genome-wide Identification and Characterisation of Tissue-specific RNA Editing Events in <i>D. melanogaster</i> and their Potential Role in Regulating Alternative Splicing

description: RNA editing is a widespread mechanism that plays a crucial role in diversifying gene products. Its abundance and importance in regulating cellular processes were revealed using new sequencing technologies. The majority of these editing events, however, cannot be associated with regulatory mechanisms. We use tissue-specific high-throughput libraries of <i>D. melanogaster</i> to study RNA editing. We introduce an analysis pipeline that utilises large input data and explicitly captures ADAR's requirement for double-stranded regions. It combines probabilistic and deterministic filters and can identify RNA editing events with a low estimated false positive rate. Analysing ten different tissue types, we predict 2879 editing sites and provide their detailed characterisation. Our analysis pipeline accurately distinguishes genuine editing sites from SNPs and sequencing and mapping artefacts. Our editing sites are three times more likely to occur in exons with multiple splicing acceptor/donor sites than in exons with unique splice sites (p-value &lt; 2 10–15). Furthermore, we identify 244 edited regions where RNA editing and alternative splicing are likely to influence each other. For 96 out of these 244 regions, we find evolutionary evidence for conserved RNA secondary-structures near splice sites suggesting a potential regulatory mechanism where RNA editing may alter splicing patterns via changes in local RNA structure.
DOI: 10.6084/m9.figshare.1588556
title: Identification of novel proteins binding the AU-rich element of α-prothymosin mRNA through the selection of open reading frames (RIDome)

description: ABSTRACTWe describe here a platform for high-throughput protein expression and interaction analysis aimed at identifying the RNA-interacting domainome. This approach combines the selection of a phage library displaying “filtered” open reading frames with next-generation DNA sequencing. The method was validated using an RNA bait corresponding to the AU-rich element of α-prothymosin, an RNA motif that promotes mRNA stability and translation through its interaction with the RNA-binding protein ELAVL1. With this strategy, we not only confirmed known RNA-binding proteins that specifically interact with the target RNA (such as ELAVL1/HuR and RBM38) but also identified proteins not previously known to be ARE-binding (R3HDM2 and RALY). We propose this technology as a novel approach for studying the RNA-binding proteome.