cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21430/m3tswjovtm
title: Evolutionary transcriptomics implicates HAND2

description: The study assembled a collection of gene expression data from the pregnant/gravid maternal-fetal interface of tetrapods and used evolutionary methods to reconstruct gene expression changes during the origins of mammalian pregnancy. And found genes were enriched for immune functions and diseases, as well as preterm birth. A subsequent analysis was on the HAND2 gene expression dynamics from re-analysis of existing data and focused on the HAND2 gene regulations in endometrial stromal fibroblasts, and the functional analysis of identified IL15 gene by trans-well migration assays. Collectively, these data connect HAND2 expression at the maternal-fetal interface with evolution of implantation and gestational regulation, and preterm birth.
DOI: 10.21430/m3tu8p1dq0
title: Maternal plasma miRNAs as potential biomarkers for detecting risk of SGA

description: To investigate the miRNA biomarkers asssociated with the Small-for-gestational-age fetuses (SGA) condition, maternal plasma samples from 29 women (N=16 normal, N=13 SGA) were selected to form a discovery cohort in which expression data for a total of 800 miRNAs was determined using the Nanostring nCounter miRNA assay. Differential expression of two miRNA markers; hsa-miR-374a-5p (p = 0•0176) and hsa-let-7d-5p (p = 0•0036), were validated in an independent population of 95 women (SGA n = 12, Control n = 83).
DOI: 10.21430/m3ucu1azlc
title: Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults - Vaccine Safety Cohort

description: Pilot open label safety phase, in 12 subjects, of a Phase 1 randomized, double blind, placebo-controlled trial to assess the safety and immunogenicity of intravenous (IV) administration of cryopreserved radiation attenuated Pf sporozoites (SPZ) and the vaccine efficacy (VE) against naturally occurring malaria infection in healthy African adults.
DOI: 10.21430/m3uejmbvui
title: Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults (CoFAR1)

description: The purpose of this study is to evaluate the safety and side effects of a study product that contains recombinant modified peanut proteins (EMP-123) in healthy and peanut-allergic participants.
DOI: 10.21430/m3ul8417lg
title: Controlled malaria infection in Europeans and Africans

description: Comparison of immune signatures of malaria-naive Europeans and of Africans with lifelong malaria exposure using mass cytometry, flow cytometry, RNA-Seq, before and 5 and 11 days after venous inoculation with Plasmodium falciparum sporozoites (PfSPZ)
DOI: 10.21430/m3unsl0593
title: 43rd Multicenter Airway Research Collaboration (MARC-43)

description: As a part of multicenter prospective study, we collected stool samples from 115 healthy infants (age <1 year). By applying 16S rRNA gene sequencing and an unbiased clustering approach to these fecal samples, we identified 4 distinct microbiota profiles: Escherichia-dominant profile, Bifidobacterium-dominant profile, Enterobacter/Veillonella-dominant profile, and Bacteroides-dominant profile.
DOI: 10.21430/m3vgvkprv0
title: Strategies to Improve Long Term Islet Graft Survival (CIT-02) and Extended Follow Up after Islet Transplantation in Type 1 Diabetes (CIT-08)

description: CIT-02: Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control. The purpose of this study is to determine the safety and effectiveness of islet transplantation, combined with immunosuppressive medications and medications to support islet survival, for treating type 1 diabetes in individuals experiencing hypoglycemia unawareness and severe hypoglycemic episodes. CIT-08: The purpose of this protocol is to collect long-term follow-up information on the safety and efficacy of islet transplantation in CIT subjects after their completion in their CIT parent study.
DOI: 10.21430/m3w2vvin1s
title: SR Tacrolimus Safety and PK Study in Healthy Subjects

description: This first-in-human study is designed to assess the safety and pharmacokinetic (PK) profile of sustained-release (SR) depot tacrolimus, which will be administered as a single dose of 0.1 mg/kg by subcutaneous (SC) injection in healthy subjects.
DOI: 10.21430/m3w5px1q02
title: Clinical Immunology of Infant Macaques

description: We collected and analyzed blood samples from 151 healthy rhesus
DOI: 10.21430/m3wbutvto4
title: High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS

description: The study developed the LC/MS/MS assay to quantify 16 ceramides and 10 dihydroceramides in human serum within 5 minutes. Validated the assay results against a set of quality criteria in FDA guidelines: Lower Limit of Quantitation (1 nM), linearity (R2>0.99), precision (imprecision<15 %), accuracy (inaccuracy<15 %), extraction recovery (>90 %), stability (>85 %), and carryover (<0.01 %). With enhanced sensitivity and specificity, the study established gestation baselines of ceramides and dihydroceramides in pregnancy
DOI: 10.21430/m3wepi1ha3
title: B-cell Immunity to Influenza (SLVP017) 2013

description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
DOI: 10.21430/m3xaasi63d
title: Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults - Vaccine Efficacy and Placebo Cohorts

description: A Phase 1 randomized, double blind, placebo-controlled trial to assess the safety and immunogenicity of intravenous (IV) administration of cryopreserved radiation attenuated Pf sporozoites (SPZ) and the vaccine efficacy (VE) against naturally occurring malaria infection in healthy African adults. After establishing safety of PfSPZ Vaccine in a pilot group (N=12), subjects received either 5 doses of PfSPZ Vaccine (N=48) or normal saline (NS) placebo (N=48). VE was assessed by detection of Pf by thick blood smear (TBS) for 24 weeks after last dose of vaccine or NS.
DOI: 10.21430/m3xi6tna0k
title: Single-cell transcriptomics of human T cells

description: This study characterizes human T cells across several lyphoid and mucosal tissues from two individual organ donors plus blood donors using single cell transcriptome analysis, flow cytometry, and quantitative PCR.
DOI: 10.21430/m3ygg9r72b
title: Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

description: The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors.
DOI: 10.21430/m3yrxtc32z
title: A Retrospective Multicenter study to Determine Up to 5 Year Clinical Outcomes in Subjects Previously Randomized in the CTOT-11 Study (CTOT-23)

description: This study is a multicenter, non-randomized, retrospective study to collect long term (3 to 5 years post-transplant) clinical outcome data on subjects previously enrolled in the CTOT-11 study.
DOI: 10.21430/m3z1k1q8kr
title: MDR1 expression in hematopeotic cells

description: We generated MDR1-reporter (Abcb1aAME /+) mice to quantify steady-state Abcb1a expression in more than 100 immune cell types and developmental stage.
DOI: 10.21430/m3z5ufk8gc
title: Double Expressor Assessment

description: Determine the frequency of double expressor lymphocytes of frozen PBMCs from T1D patients and health controls through flow cytometry.
DOI: 10.21430/m3znd7zkx0
title: Immune signatures of responses to infection with Dengue and Zika virus

description: Comparing immune mechanisms prevailing in DENV-patients and virus-exposed healthy subjects in the Indian population to define critical elements of anti-viral immunity.
DOI: 10.21430/m300ytt71x
title: Deficiency of PD-L1+ Non-Immune Cells in Preterm Labor

description: The objective of this study was to characterize the cells at the maternal-fetal interface (MFI) in term and preterm pregnancies, each in the laboring and non-laboring state. Using mass cytometry to obtain single-cell resolution, we identified 31 cell populations at the MFI, including 25 immune cell types and six non-immune cell types. Among the immune cells, maternal PD1+ CD8 T cells subsets were less abundant in term laboring compared to term non-laboring. Among the non-immune cells, PD-L1+ maternal (stromal) and fetal (extravillous trophoblast) cells were more abundant in term laboring compared to preterm laboring pregnancies. Consistent with these observations, the expression of CD274, the gene encoding PD-L1, was significantly depressed and less responsive to fetal signaling molecules in cultured mesenchymal stromal cells from the decidua of preterm compared to term pregnancies. Overall, these results suggest that the PD1/PD-L1 pathway at the MFI may perturb the delicate balance between immune tolerance and rejection and contribute to the onset of spontaneous preterm labor.
DOI: 10.21430/m30v1nqbf0
title: Mapping Immune Responses to CMV in Renal Transplantation

description: CMV is one of the most problematic pathogens in the immunocompromised host after solid organ and stem cell transplantation, increasing morbidity and mortality risk, and graft loss. Approaches for improved understanding and subsequent harnessing of the host immune response to CMV are needed to reduce the burden of CMV complications in immunocompromised individuals, including chronic injury of the transplanted organ.
DOI: 10.21430/m316lyqmug
title: ZIKV ex vivo PBMCs study

description: Ex vivo infections of DCs ZIKV and DENV
DOI: 10.21430/m319oci0ws
title: A Peripheral Immune Signature of Labor Induction

description: To characterize labor-associated maternal immune system dynamics from labor induction to the start of active labor, serial blood samples from 15 participants were collected immediately prior to labor induction (baseline) and during the latent phase until the start of active labor. Using high-dimensional mass cytometry, a total of 1,059 single-cell immune features were extracted from each sample. A multivariate machine-learning method (LASSO) was employed to predict labor induction (minutes) with high accuracy. The most informative immune features include STAT5 signaling in central memory CD8+ T cells and pro-inflammatory STAT3 signaling responses across multiple adaptive and innate immune cell subsets. The prediction model may ultimately predict labor induction success as well as complications.
DOI: 10.21430/m31b69o6ul
title: Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

description: To evaluate the immunogenicity and protective efficacyof novel rhesus adenovirus serotype 52 (RhAd52) vaccines against MA10 challenge inmice
DOI: 10.21430/m31f88a9ql
title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

description: Here, we find that SARS-CoV-2 replication induces a delayed interferon (IFN) response in lung epithelial cells. By screening 16 putative sensors involved in sensing of RNA virus infection, we found that MDA5 and LGP2 primarily regulate IFN induction in response to SARS-CoV-2 infection. Further analyses revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing. Additionally, we find that IRF3, IRF5, and NF-B/p65 are the key transcription factors regulating the IFN response during SARS-CoV-2 infection. In summary, these findings provide critical insights into the molecular basis of the innate immune recognition and signaling response to SARS-CoV-2.
DOI: 10.21430/m31fwxieu2
title: Early prediction of preeclampsia in pregnancy with cfRNA

description: To identify and validate cell-free RNA (cfRNA) transcriptomic changes that are associated with preeclampsia, the study generated circulating cfRNA profiles in blood from comparative cohorts: normotensive and preeclamptic pregnant mothers ( 404 blood samples from 199 participants). Results: 1) the changes are marked and stable early in gestation, well before the onset of symptoms. 2) changes are enriched for genes specific to neuromuscular, endothelial and immune cell types and tissues that reflect key aspects of preeclampsia physiology. 3) independent validation of a panel of 18 genes that when measured between 5 and 16 weeks of gestation can form the basis of a liquid biopsy test on at-risk of preeclampsia mothers.
DOI: 10.21430/m31k1v0i9f
title: Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response

description: The study integrated longitudinal vaginal microbiota and cervicovaginal fluid (CVF) immunophenotype data collected from 133 women at high-risk of sPTB. The results show that vaginal depletion of Lactobacillus species and high bacterial diversity leads to increased mannose binding lectin (MBL), IgM, IgG, C3b, C5, IL-8, IL-6 and IL-1β and to increased risk of sPTB. Cervical shortening, which often precedes preterm birth, is associated with Lactobacillus iners and elevated levels of IgM, C3b, C5, C5a and IL-6.
DOI: 10.21430/m31m7vl89n
title: Durability and Cross-Reactivity of SARS-CoV-2 mRNA Vaccine in Adolescent Children

description: To test the durability and cross-reactivity of anti-SARS-CoV-2 serologic responses over a six-month time course in vaccinated adolescents against the SARS-CoV-2 D614G (“wild type”) and Omicron antigens
DOI: 10.21430/m31pqifa91
title: Immunization Via Mosquito Bite With Radiation-Attenuated Plasmodium Falciparum Sporozoites (IMRAS)

description: This study is to assess the safety, tolerability, and biomarkers of protection in healthy malaria-naive adults, who will receive bites from Anopheles stephensi mosquitoes either infected with Plasmodium falciparum Sporozoites (PfRAS) (true-immunization) or noninfected (mock-immunization).
DOI: 10.21430/m31tx0gfhu
title: Summary

description: We assessed the kinetics and durability of SARS-CoV-2-specific antibodies, CD4+ T cells, and CD8+ T cells made in response to SARS-CoV-2 infection in a predominantly cross-sectional study extending up to eight months post-infection. ** THIS STUDY CONTAINS THE DATA FOR SDY1870 **.
DOI: 10.21430/m31w8dcc1w
title: Multicenter Mayo Genomics Trial (GEN-04)

description: The purpose of this study is to determine if certain genes found in a kidney biopsy performed at one-year post transplant can predict which transplanted kidneys will have decreased kidney function within five years post-transplant.
DOI: 10.21430/m31wz81nlc
title: Mathematical Modeling to Inform Vaccination Strategies and Testing Approaches for Coronavirus Disease 2019 (COVID-19) in Nursing Homes

description: Encouraging staff vaccination is not only important for protecting staff, but might also reduce symptomatic cases in residents if a vaccine confers at least some protection against infection or infectiousness
DOI: 10.21430/m31xbtvkkn
title: Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

description: Compare response to BNT162b2 Messenger RNA Vaccine in nursing home residents to those of healthcare workers and unvaccinated convalescent SARS-CoV-2 cases, stratified by prior SARS-CoV-2 infection.
DOI: 10.21430/m320nkdif3
title: Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults

description: Identify age- and response-related metabolic signatures to after influenza vaccination.
DOI: 10.21430/m337obg0uc
title: Function Is More Reliable Than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination

description: In this work, we report that in a subset of patients -despite a decline in total S-specific antibodies- neutralizing antibody titers remain at a similar level for an average of 98 days in longitudinal sampling of a cohort of 59 Hispanic/Latino patients exposed to SARS-CoV-2. Our data suggest that 100% of seroconverting patients make detectable neutralizing antibody responses which can be quantified by a surrogate viral neutralization test. Examination of sera from ten out of the 59 subjects which received mRNA-based vaccination revealed that both IgG titers and neutralizing activity of sera were higher after vaccination compared to a cohort of 21 SARS-CoV-2 naïve subjects. One dose was sufficient for the induction of a neutralizing antibody, but two doses were necessary to reach 100% surrogate virus neutralization in subjects irrespective of previous SARS-CoV-2 natural infection status. Like the pattern observed after natural infection, the total anti-S antibodies titers declined after the second vaccine dose; however, neutralizing activity remained relatively constant for more than 80 days after the first vaccine dose. Furthermore, our data indicates that -compared with mRNA vaccination- natural infection induces a more robust humoral immune response in unexposed subjects. This work is an important contribution to understanding the natural immune response to the novel coronavirus in a population severely impacted by SARS-CoV-2.
DOI: 10.21430/m33d4y9rtm
title: Proinflammatory IgG Fc structures in patients with severe COVID-19

description: Patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
DOI: 10.21430/m33dawueid
title: Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

description: Here, we fit structured compartmental models to seroprevalence data from New York State and analyze how herd immunity thresholds (HITs), final sizes, and epidemic risk change across groups. Across all models, the burden of infection fell disproportionately on minority populations: in a model fit to Long Island serosurvey and census data, 81% of Hispanics or Latinos were infected when the HIT was reached compared to 34% of non-Hispanic whites. Our findings, which are meant to be illustrative and not best estimates, demonstrate how racial and ethnic disparities can impact epidemic trajectories and result in unequal distributions of SARS-CoV-2 infection.
DOI: 10.21430/m35aujbtw2
title: B Cell Induction in Pediatric Lung Transplantation (CTOTC-08)

description: In this study, doctors are trying to see if a study drug called rituximab (Rituxan) will lower the number of B cells in the body. Doctors are also trying to see if decreasing B cells with rituximab (Rituxan) can prevent injury to the transplanted lung. This treatment has been studied in other types of solid organ transplants.
DOI: 10.21430/m35pwv2m56
title: Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity

description: Infection is the most common cause of death in early life, especially for newborns and can be reduced by immunization but insufficient knowledge of how vaccines protect the very young limits their optimal use. To gain insight into how vaccines induce protection of the most vulnerable, our project employs two novel approaches studying newborn responses to hepatitis B vaccine (HBV): (a) systems biology that uses technologies which comprehensively measure global changes in molecules such as transcriptomics (RNA) and proteomics (proteins), as well as cell composition of the blood and (b) use of human newborn blood components, collected prior to immunization, to model vaccine responses in vitro (outside the body). Characterizing vaccine-induced molecular patterns (signatures) that correspond to vaccine-mediated protection will accelerate development and optimization of vaccines against early life infections of major global health importance.
DOI: 10.21430/m364xz81g8
title: Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19

description: Randomized, double-blind, placebo-controlled clinical trial of Ad26.COV2.S on 25 participants. Participants were randomized to receive single-shot and 2-shot vaccine regimens with either 5 X 1010 or 1 X 1011 viral particles of Ad26.COV2.S or placebo in healthy adults 18 to 55 years of age.
DOI: 10.21430/m36a5z1xu9
title: Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

description: To investigate whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines.
DOI: 10.21430/m36er193hy
title: SARS-CoV-2 vaccine uptake, perspectives, and adverse reactions following vaccination in patients with cancer undergoing treatment

description: We report data on uptake and perspectives on SARS-CoV-2 vaccination and postvaccination adverse reactions in 208 recently diagnosed patients with cancer (median age 63 years, 52.4% women, 33.2% non-White minorities, Table 1 ) at a large healthcare system in Los Angeles spanning the timeline from limited vaccine availability to broader dissemination (November 2020 to July 2021). Vaccine hesitancy and perspectives were measured using a modified version of the World Health Organization Vaccine Hesitancy Scale (Supplementary Material, available at https://doi.org/10.1016/j.annonc.2021.10.005).3 A self-administered symptoms questionnaire was given to vaccinated recipients after dose 1 (D1) and D2 for messenger RNA (mRNA) SARS-CoV-2 vaccines. Electronic medical records provided correlative clinical information. Chi-square tests were used to assess differences for categorical variables and a Wilcoxon rank-sum test for continuous variables (Stata v. 15.1). All tests were two-sided and considered statistically significant at P < 0.05.
DOI: 10.21430/m36kc4l9g2
title: A multiomics study in a Japanese rheumatoid arthritis cohort

description: The KURAMA cohort is an observational cohort that was established in May 2011 at the Center for Rheumatic Disease at Kyoto University Hospital to achieve strict control of RA.
DOI: 10.21430/m36m272qbe
title: Phase 1, dose escalation, randomized controlled trial to evaluate the safety, immunogenicity and efficacy of intravenously administered attenuated Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine) in Tanzanian adults

description: Second trial of PfSPZ Vaccine in sub-Saharan Africa to assess safety, immunogenicitiy and efficacy. First trial in sub-Saharan Africa to assess PfSPZ Vaccine efficacy by CHMI using PfSPZ Chllenge.
DOI: 10.21430/m36qz9vxr6
title: Vaccine protection against the SARS-CoV-2 Omicron variant in macaques

description: mRNA-based BNT162b2 vaccine and the adenovirus-vector-based Ad26.COV2.S vaccine provide robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in cynomolgus macaques.
DOI: 10.21430/m37bkvg03k
title: Mouse blood gene expression after administration of 137 Cesium

description: In the current study, we investigated the gene expression response of blood cells of mice that were injected with variable amounts of 137Cs. We isolated total RNA from peripheral blood from mice with 0 (control), 158, 191, 215 and 259 uCi cesium source amount on days 2, 3, 5, 7 and 14 days after injection. Using Agilent Mouse Whole Genome microarrays, we identified x genes that were significantly differentially expressed across the 14-day time course of this study. We identified common biological functions affected that persisted across the 14-day study.