cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5880/geofon.gfz2013rhmj
title: GEOFON event gfz2013rhmj (Southeast of Honshu, Japan; Magnitude 6.5)

description: Earthquake, 2013-09-04 00:18:25, Southeast of Honshu, Japan
DOI: 10.15468/dl.b8vmdk
title: Occurrence Download

description: A dataset containing 287 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((119.4917 29.68143,121.08514 29.68143,121.08514 30.91029,119.4917 30.91029,119.4917 29.68143))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Colubridae"
 ]
}

 The dataset includes 287 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051170-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/14141711
title: Dataset for fine-tuning LLM to generate MiniZinc
DOI: 10.5880/geofon.gfz2013rhqu
title: GEOFON event gfz2013rhqu (Andreanof Islands, Aleutian Islands; Magnitude 6.5)

description: Earthquake, 2013-09-04 02:32:30, Andreanof Islands, Aleutian Islands
DOI: 10.5880/geofon.gfz2013rjpf
title: GEOFON event gfz2013rjpf (Northern Mid Atlantic Ridge; Magnitude 6.0)

description: Earthquake, 2013-09-05 04:01:36, Northern Mid Atlantic Ridge
DOI: 10.5880/geofon.gfz2013rmys
title: GEOFON event gfz2013rmys (Near Coast of Chiapas, Mexico; Magnitude 6.5)

description: Earthquake, 2013-09-07 00:13:32, Near Coast of Chiapas, Mexico
DOI: 10.5880/geofon.gfz2013rvfm
title: GEOFON event gfz2013rvfm (Central East Pacific Rise; Magnitude 6.0)

description: Earthquake, 2013-09-11 12:44:14, Central East Pacific Rise
DOI: 10.15468/dl.q98ycx
title: Occurrence Download

description: A dataset containing 257984 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is one of (Geothlypis philadelphia)",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence)",
 "Year is greater than or equal to 1951",
 "Year is less than or equal to 2024",
 "Month is greater than or equal to April",
 "Month is less than or equal to July",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 257984 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051160-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5880/geofon.gfz2013scur
title: GEOFON event gfz2013scur (Andreanof Islands, Aleutian Islands; Magnitude 6.0)

description: Earthquake, 2013-09-15 16:21:40, Andreanof Islands, Aleutian Islands
DOI: 10.5880/geofon.gfz2008aamz
title: GEOFON event gfz2008aamz (Kyrgyzstan; Magnitude 5.8)

description: Earthquake, 2008-01-01 06:32:34, Kyrgyzstan
DOI: 10.5880/geofon.gfz2008brsr
title: GEOFON event gfz2008brsr (Tonga Islands; Magnitude 5.8)

description: Earthquake, 2008-01-24 22:39:12, Tonga Islands
DOI: 10.5880/geofon.gfz2008cfns
title: GEOFON event gfz2008cfns (Fiji Islands Region; Magnitude 5.8)

description: Earthquake, 2008-02-01 12:10:05, Fiji Islands Region
DOI: 10.5880/geofon.gfz2008crdz
title: GEOFON event gfz2008crdz (Bali Sea; Magnitude 6.0)

description: Earthquake, 2008-02-07 20:58:20, Bali Sea
DOI: 10.5880/geofon.gfz2008dhcx
title: GEOFON event gfz2008dhcx (Chile-Bolivia Border Region; Magnitude 5.8)

description: Earthquake, 2008-02-16 14:45:10, Chile-Bolivia Border Region
DOI: 10.5880/geofon.gfz2008dosd
title: GEOFON event gfz2008dosd (Southern Greece; Magnitude 6.0)

description: Earthquake, 2008-02-20 18:27:08, Southern Greece
DOI: 10.5880/geofon.gfz2008dzqr
title: GEOFON event gfz2008dzqr (Southwest of Sumatra, Indonesia; Magnitude 6.0)

description: Earthquake, 2008-02-26 18:18:28, Southwest of Sumatra, Indonesia
DOI: 10.5880/geofon.gfz2008flfy
title: GEOFON event gfz2008flfy (Kermadec Islands, New Zealand; Magnitude 5.8)

description: Earthquake, 2008-03-18 08:22:44, Kermadec Islands, New Zealand
DOI: 10.5880/geofon.gfz2008ibcc
title: GEOFON event gfz2008ibcc (Central Mid Atlantic Ridge; Magnitude 5.8)

description: Earthquake, 2008-04-24 12:14:51, Central Mid Atlantic Ridge
DOI: 10.5880/geofon.gfz2008jiog
title: GEOFON event gfz2008jiog (Sichuan, China; Magnitude 5.8)

description: Earthquake, 2008-05-12 20:08:53, Sichuan, China
DOI: 10.5880/geofon.gfz2008jsxn
title: GEOFON event gfz2008jsxn (Southern Sumatra, Indonesia; Magnitude 5.8)

description: Earthquake, 2008-05-18 12:17:25, Southern Sumatra, Indonesia
DOI: 10.5880/geofon.gfz2008jwyb
title: GEOFON event gfz2008jwyb (Southern Sumatra, Indonesia; Magnitude 5.8)

description: Earthquake, 2008-05-20 17:08:01, Southern Sumatra, Indonesia
DOI: 10.5880/geofon.gfz2008msgj
title: GEOFON event gfz2008msgj (Primor'ye, Russia; Magnitude 5.8)

description: Earthquake, 2008-06-29 20:53:02, Primor'ye, Russia
DOI: 10.5880/geofon.gfz2008mulu
title: GEOFON event gfz2008mulu (East of South Sandwich Islands; Magnitude 5.8)

description: Earthquake, 2008-07-01 01:54:42, East of South Sandwich Islands
DOI: 10.5880/geofon.gfz2008nnch
title: GEOFON event gfz2008nnch (South of Java, Indonesia; Magnitude 5.8)

description: Earthquake, 2008-07-11 06:51:36, South of Java, Indonesia
DOI: 10.5880/geofon.gfz2008ojzu
title: GEOFON event gfz2008ojzu (Sichuan, China; Magnitude 5.8)

description: Earthquake, 2008-07-23 19:54:45, Sichuan, China
DOI: 10.5880/geofon.gfz2008okwa
title: GEOFON event gfz2008okwa (Sichuan, China; Magnitude 5.8)

description: Earthquake, 2008-07-24 07:09:29, Sichuan, China
DOI: 10.5880/geofon.gfz2008petj
title: GEOFON event gfz2008petj (Kuril Islands; Magnitude 5.8)

description: Earthquake, 2008-08-04 04:42:11, Kuril Islands
DOI: 10.5880/geofon.gfz2008pxmx
title: GEOFON event gfz2008pxmx (Kuril Islands; Magnitude 5.8)

description: Earthquake, 2008-08-14 11:10:29, Kuril Islands
DOI: 10.15468/dl.pes3kp
title: Occurrence Download

description: A dataset containing 139292 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tracheophyta",
 "DecimalLatitude is greater than or equal to -50.914722",
 "DecimalLatitude is less than or equal to -45.914722",
 "DecimalLongitude is greater than or equal to 165.0",
 "DecimalLongitude is less than or equal to 170.0",
 "HasCoordinate is TRUE",
 "HasGeospatialIssue is FALSE"
 ]
}

 The dataset includes 139292 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051161-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5880/geofon.gfz2008tzgf
title: GEOFON event gfz2008tzgf (Eastern Caucasus; Magnitude 6.0)

description: Earthquake, 2008-10-11 09:06:12, Eastern Caucasus
DOI: 10.5880/geofon.gfz2008uvek
title: GEOFON event gfz2008uvek (Mindanao, Philippines; Magnitude 5.8)

description: Earthquake, 2008-10-23 09:21:15, Mindanao, Philippines
DOI: 10.5880/geofon.gfz2009afeh
title: GEOFON event gfz2009afeh (Irian Jaya Region, Indonesia; Magnitude 6.0)

description: Earthquake, 2009-01-03 19:53:18, Irian Jaya Region, Indonesia
DOI: 10.5880/geofon.gfz2009ahgi
title: GEOFON event gfz2009ahgi (Hindu Kush Region, Afghanistan; Magnitude 5.8)

description: Earthquake, 2009-01-04 23:13:01, Hindu Kush Region, Afghanistan
DOI: 10.5880/geofon.gfz2009baut
title: GEOFON event gfz2009baut (Solomon Islands; Magnitude 5.8)

description: Earthquake, 2009-01-15 16:15:00, Solomon Islands
DOI: 10.5880/geofon.gfz2009bnjz
title: GEOFON event gfz2009bnjz (New Britain Region, P.N.G.; Magnitude 6.0)

description: Earthquake, 2009-01-22 13:40:28, New Britain Region, P.N.G.
DOI: 10.5880/geofon.gfz2009cell
title: GEOFON event gfz2009cell (Near East Coast of Honshu, Japan; Magnitude 5.8)

description: Earthquake, 2009-01-31 21:51:53, Near East Coast of Honshu, Japan
DOI: 10.5880/geofon.gfz2009chun
title: GEOFON event gfz2009chun (Near Coast of Peru; Magnitude 5.8)

description: Earthquake, 2009-02-02 17:53:23, Near Coast of Peru
DOI: 10.5880/geofon.gfz2009cuhk
title: GEOFON event gfz2009cuhk (Near Coast of Northern Peru; Magnitude 5.8)

description: Earthquake, 2009-02-09 14:09:05, Near Coast of Northern Peru
DOI: 10.5880/geofon.gfz2009cygv
title: GEOFON event gfz2009cygv (Talaud Islands, Indonesia; Magnitude 5.8)

description: Earthquake, 2009-02-11 18:25:12, Talaud Islands, Indonesia
DOI: 10.15468/dl.9taygh
title: Occurrence Download

description: A dataset containing 617654 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Netherlands",
 "Geometry POLYGON((2.53596 49.97178,8.01691 49.97178,8.01691 54.13356,2.53596 54.13356,2.53596 49.97178))",
 "TaxonKey is Apidae",
 "Year 2020-2025"
 ]
}

 The dataset includes 617654 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051159-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5880/geofon.gfz2009cyoj
title: GEOFON event gfz2009cyoj (Talaud Islands, Indonesia; Magnitude 6.0)

description: Earthquake, 2009-02-11 22:14:31, Talaud Islands, Indonesia
DOI: 10.5880/geofon.gfz2009dadg
title: GEOFON event gfz2009dadg (Kermadec Islands Region; Magnitude 6.0)

description: Earthquake, 2009-02-12 18:54:31, Kermadec Islands Region
DOI: 10.5880/geofon.gfz2009exib
title: GEOFON event gfz2009exib (Costa Rica; Magnitude 6.0)

description: Earthquake, 2009-03-11 17:24:39, Costa Rica
DOI: 10.5880/geofon.gfz2009gfpo
title: GEOFON event gfz2009gfpo (Andreanof Islands, Aleutian Islands; Magnitude 5.8)

description: Earthquake, 2009-03-30 12:07:32, Andreanof Islands, Aleutian Islands
DOI: 10.5880/geofon.gfz2009gfps
title: GEOFON event gfz2009gfps (Andreanof Islands, Aleutian Islands; Magnitude 5.8)

description: Earthquake, 2009-03-30 12:11:58, Andreanof Islands, Aleutian Islands
DOI: 10.5880/geofon.gfz2009hnnq
title: GEOFON event gfz2009hnnq (Kermadec Islands Region; Magnitude 6.0)

description: Earthquake, 2009-04-18 02:03:53, Kermadec Islands Region
DOI: 10.5880/geofon.gfz2009ilor
title: GEOFON event gfz2009ilor (Solomon Islands; Magnitude 5.8)

description: Earthquake, 2009-05-01 06:03:11, Solomon Islands
DOI: 10.5880/geofon.gfz2009iqaa
title: GEOFON event gfz2009iqaa (Guatemala; Magnitude 5.8)

description: Earthquake, 2009-05-03 16:21:48, Guatemala
DOI: 10.5880/geofon.gfz2009jemf
title: GEOFON event gfz2009jemf (Southern Mid Atlantic Ridge; Magnitude 5.8)

description: Earthquake, 2009-05-11 14:32:32, Southern Mid Atlantic Ridge
DOI: 10.5880/geofon.gfz2009jgdx
title: GEOFON event gfz2009jgdx (Mid Indian Ridge; Magnitude 5.8)

description: Earthquake, 2009-05-12 12:38:31, Mid Indian Ridge
DOI: 10.5880/geofon.gfz2009jnxd
title: GEOFON event gfz2009jnxd (Kodiak Island Region, Alaska; Magnitude 5.8)

description: Earthquake, 2009-05-16 18:22:32, Kodiak Island Region, Alaska
DOI: 10.5880/geofon.gfz2009lakj
title: GEOFON event gfz2009lakj (Northern Mid Atlantic Ridge; Magnitude 6.0)

description: Earthquake, 2009-06-06 20:33:29, Northern Mid Atlantic Ridge
DOI: 10.15468/dl.mdv9re
title: Occurrence Download

description: A dataset containing 14 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is one of (Spain, Andorra)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Lacerta agilis",
 "Year 1970-2010"
 ]
}

 The dataset includes 14 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051171-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5880/geofon.gfz2009lknv
title: GEOFON event gfz2009lknv (Vanuatu Islands; Magnitude 5.8)

description: Earthquake, 2009-06-12 09:44:16, Vanuatu Islands
DOI: 10.5880/geofon.gfz2009lsqf
title: GEOFON event gfz2009lsqf (Bouvet Island Region; Magnitude 5.8)

description: Earthquake, 2009-06-16 20:05:57, Bouvet Island Region
DOI: 10.5880/geofon.gfz2009lxqs
title: GEOFON event gfz2009lxqs (Eastern Mediterranean Sea; Magnitude 5.8)

description: Earthquake, 2009-06-19 14:05:00, Eastern Mediterranean Sea
DOI: 10.5880/geofon.gfz2009nexi
title: GEOFON event gfz2009nexi (Baffin Bay; Magnitude 6.0)

description: Earthquake, 2009-07-07 19:11:47, Baffin Bay
DOI: 10.5880/geofon.gfz2009nnba
title: GEOFON event gfz2009nnba (Southern Peru; Magnitude 6.0)

description: Earthquake, 2009-07-12 06:12:47, Southern Peru
DOI: 10.5880/geofon.gfz2009npfs
title: GEOFON event gfz2009npfs (Sumba Region, Indonesia; Magnitude 6.0)

description: Earthquake, 2009-07-13 10:52:21, Sumba Region, Indonesia
DOI: 10.5880/geofon.gfz2009nsui
title: GEOFON event gfz2009nsui (Off W. Coast of S. Island, N.Z.; Magnitude 5.8)

description: Earthquake, 2009-07-15 09:41:54, Off W. Coast of S. Island, N.Z.
DOI: 10.5880/geofon.gfz2009onwx
title: GEOFON event gfz2009onwx (Vanuatu Islands; Magnitude 6.0)

description: Earthquake, 2009-07-26 23:01:33, Vanuatu Islands
DOI: 10.15468/dl.xs9sn4
title: Occurrence Download

description: A dataset containing 68 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Belgium",
 "GadmGid is BEL.3.3_1",
 "OccurrenceStatus is Present",
 "TaxonKey is Ailanthus altissima",
 "Year 2025-2025"
 ]
}

 The dataset includes 68 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0051173-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5880/geofon.gfz2009powp
title: GEOFON event gfz2009powp (Near N. Coast of New Guinea, PNG.; Magnitude 5.8)

description: Earthquake, 2009-08-10 17:46:27, Near N. Coast of New Guinea, PNG.
DOI: 10.5880/geofon.gfz2009quok
title: GEOFON event gfz2009quok (Qinghai, China; Magnitude 5.8)

description: Earthquake, 2009-08-28 02:14:59, Qinghai, China
DOI: 10.5880/geofon.gfz2009rgwa
title: GEOFON event gfz2009rgwa (Myanmar-India Border Region; Magnitude 6.0)

description: Earthquake, 2009-09-03 19:51:09, Myanmar-India Border Region
DOI: 10.5880/geofon.gfz2009rojo
title: GEOFON event gfz2009rojo (Northwestern Caucasus; Magnitude 6.0)

description: Earthquake, 2009-09-07 22:41:37, Northwestern Caucasus
DOI: 10.5880/geofon.gfz2009rpxl
title: GEOFON event gfz2009rpxl (Minahassa Peninsula, Sulawesi; Magnitude 5.8)

description: Earthquake, 2009-09-08 18:51:24, Minahassa Peninsula, Sulawesi
DOI: 10.5880/geofon.gfz2009rqxq
title: GEOFON event gfz2009rqxq (Northern Molucca Sea; Magnitude 5.8)

description: Earthquake, 2009-09-09 08:06:35, Northern Molucca Sea
DOI: 10.5880/geofon.gfz2009shfn
title: GEOFON event gfz2009shfn (Mindoro, Philippines; Magnitude 6.0)

description: Earthquake, 2009-09-18 06:23:55, Mindoro, Philippines
DOI: 10.5880/geofon.gfz2009simp
title: GEOFON event gfz2009simp (South of Bali, Indonesia; Magnitude 6.0)

description: Earthquake, 2009-09-18 23:06:59, South of Bali, Indonesia
DOI: 10.5880/geofon.gfz2009tcff
title: GEOFON event gfz2009tcff (Samoa Islands Region; Magnitude 5.8)

description: Earthquake, 2009-09-29 18:21:42, Samoa Islands Region
DOI: 10.5880/geofon.gfz2009tcqa
title: GEOFON event gfz2009tcqa (Samoa Islands Region; Magnitude 5.8)

description: Earthquake, 2009-09-29 23:45:09, Samoa Islands Region
DOI: 10.5880/geofon.gfz2009tswj
title: GEOFON event gfz2009tswj (Santa Cruz Islands; Magnitude 6.0)

description: Earthquake, 2009-10-08 21:16:17, Santa Cruz Islands
DOI: 10.5880/geofon.gfz2009tvzu
title: GEOFON event gfz2009tvzu (Vanuatu Islands; Magnitude 5.8)

description: Earthquake, 2009-10-10 14:25:18, Vanuatu Islands
DOI: 10.5880/geofon.gfz2009ubgr
title: GEOFON event gfz2009ubgr (Halmahera, Indonesia; Magnitude 6.0)

description: Earthquake, 2009-10-13 11:38:08, Halmahera, Indonesia
DOI: 10.5880/geofon.gfz2009uimv
title: GEOFON event gfz2009uimv (Samoa Islands Region; Magnitude 5.8)

description: Earthquake, 2009-10-17 10:45:30, Samoa Islands Region
DOI: 10.5880/geofon.gfz2009uqwq
title: GEOFON event gfz2009uqwq (South of Panama; Magnitude 5.8)

description: Earthquake, 2009-10-22 00:51:38, South of Panama
DOI: 10.5880/geofon.gfz2009utmr
title: GEOFON event gfz2009utmr (Irian Jaya Region, Indonesia; Magnitude 6.0)

description: Earthquake, 2009-10-23 11:15:28, Irian Jaya Region, Indonesia
DOI: 10.5880/geofon.gfz2009vrcl
title: GEOFON event gfz2009vrcl (Taiwan; Magnitude 5.8)

description: Earthquake, 2009-11-05 09:32:58, Taiwan
DOI: 10.5880/geofon.gfz2009wxcj
title: GEOFON event gfz2009wxcj (Off Coast of Central Chile; Magnitude 6.0)

description: Earthquake, 2009-11-22 22:07:50, Off Coast of Central Chile
DOI: 10.5880/geofon.gfz2009xeeh
title: GEOFON event gfz2009xeeh (El Salvador; Magnitude 6.0)

description: Earthquake, 2009-11-26 19:08:14, El Salvador
DOI: 10.5880/geofon.gfz2009xhbx
title: GEOFON event gfz2009xhbx (Kermadec Islands Region; Magnitude 5.8)

description: Earthquake, 2009-11-28 09:21:21, Kermadec Islands Region
DOI: 10.5880/geofon.gfz2009xwia
title: GEOFON event gfz2009xwia (Malawi; Magnitude 5.8)

description: Earthquake, 2009-12-06 17:36:37, Malawi
DOI: 10.6084/m9.figshare.30712511
title: Supplementary files and original datasets in the article<b> “</b><b>Genome-wide characterization of Toll-like receptor genes in </b><b><i>Oreochromis niloticus</i></b><b> and their involvement in brain immune response against </b><b><i>Streptococcus agalactiae</i></b><b> infection”</b>

description: <i>Streptococcus agalactiae</i> (Group B <i>Streptococcus</i>) causes severe meningitis in tilapia (<i>Oreochromis niloticus</i>), leading to substantial economic losses in China. Toll-like receptors (TLRs), as pattern recognition receptors, play a pivotal role in innate immunity by helping the host defend against pathogenic threats. Despite their importance, a systematic characterization of TLR genes in tilapia has not been performed, and their response mechanisms in the brain remain poorly understood. In this study, we identified 19 TLR genes in the tilapia genome, including <i>TLR1-1</i>, <i>TLR1-2</i>, <i>TLR2-1</i>, <i>TLR2-2</i>, <i>TLR2-3</i>, <i>TLR2-4</i>, <i>TLR3</i>, <i>TLR5M</i>, <i>TLR5S</i>, <i>TLR7</i>, <i>TLR8-1</i>, <i>TLR8-2</i>, <i>TLR8-3</i>, <i>TLR9</i>, <i>TLR13-1</i>, <i>TLR13</i>-<i>2</i>, <i>TLR13-3</i>, <i>TLR18</i>, and <i>TLR22</i>. These genes contain conserved motifs typical of the TLR family and are distributed across 10 of the 22 chromosomes. Phylogenetic analysis classified these genes into five subfamilies: TLR1, TLR3, TLR5, TLR7, and TLR11, with the TLR4 subfamily absent. Integration of transcriptomic and single-cell data revealed that all 19 TLR genes are expressed across a variety of tissues and cells, with 14 of them (excluding <i>TLR1-1</i>, <i>TLR2-3</i>, <i>TLR5S</i>, <i>TLR13-2</i>, and<i> TLR13-3</i>) being expressed in the brain, particularly in the medulla oblongata. Furthermore, we examined the response of these 14 TLR genes to <i>S. agalactiae</i> infection in seven brain regions. Notably, <i>TLR1-2</i>, <i>TLR2-1</i>, <i>TLR5M,</i> <i>TLR8-1</i>, and<i> TLR13-1</i> were significantly upregulated in response to <i>S. agalactiae</i> infection, indicating their crucial role in the tilapia brain’s innate immune defense against <i>S. agalactiae</i>. These findings enhance our understanding of the TLR gene family in tilapia and its role in the brain’s immune response to bacterial invasion.
DOI: 10.6084/m9.figshare.30712511.v4
title: Supplementary files and original datasets in the article<b> “</b><b>Genome-wide characterization of Toll-like receptor genes in </b><b><i>Oreochromis niloticus</i></b><b> and their involvement in brain immune response against </b><b><i>Streptococcus agalactiae</i></b><b> infection”</b>

description: <i>Streptococcus agalactiae</i> (Group B <i>Streptococcus</i>) causes severe meningitis in tilapia (<i>Oreochromis niloticus</i>), leading to substantial economic losses in China. Toll-like receptors (TLRs), as pattern recognition receptors, play a pivotal role in innate immunity by helping the host defend against pathogenic threats. Despite their importance, a systematic characterization of TLR genes in tilapia has not been performed, and their response mechanisms in the brain remain poorly understood. In this study, we identified 19 TLR genes in the tilapia genome, including <i>TLR1-1</i>, <i>TLR1-2</i>, <i>TLR2-1</i>, <i>TLR2-2</i>, <i>TLR2-3</i>, <i>TLR2-4</i>, <i>TLR3</i>, <i>TLR5M</i>, <i>TLR5S</i>, <i>TLR7</i>, <i>TLR8-1</i>, <i>TLR8-2</i>, <i>TLR8-3</i>, <i>TLR9</i>, <i>TLR13-1</i>, <i>TLR13</i>-<i>2</i>, <i>TLR13-3</i>, <i>TLR18</i>, and <i>TLR22</i>. These genes contain conserved motifs typical of the TLR family and are distributed across 10 of the 22 chromosomes. Phylogenetic analysis classified these genes into five subfamilies: TLR1, TLR3, TLR5, TLR7, and TLR11, with the TLR4 subfamily absent. Integration of transcriptomic and single-cell data revealed that all 19 TLR genes are expressed across a variety of tissues and cells, with 14 of them (excluding <i>TLR1-1</i>, <i>TLR2-3</i>, <i>TLR5S</i>, <i>TLR13-2</i>, and<i> TLR13-3</i>) being expressed in the brain, particularly in the medulla oblongata. Furthermore, we examined the response of these 14 TLR genes to <i>S. agalactiae</i> infection in seven brain regions. Notably, <i>TLR1-2</i>, <i>TLR2-1</i>, <i>TLR5M,</i> <i>TLR8-1</i>, and<i> TLR13-1</i> were significantly upregulated in response to <i>S. agalactiae</i> infection, indicating their crucial role in the tilapia brain’s innate immune defense against <i>S. agalactiae</i>. These findings enhance our understanding of the TLR gene family in tilapia and its role in the brain’s immune response to bacterial invasion.
DOI: 10.5880/geofon.gfz2009xywj
title: GEOFON event gfz2009xywj (Malawi; Magnitude 6.0)

description: Earthquake, 2009-12-08 03:09:00, Malawi
DOI: 10.6084/m9.figshare.30712511.v3
title: Original data for figure in the article<b> “</b><b>Genome-wide characterization of Toll-like receptor genes in </b><b><i>Oreochromis niloticus</i></b><b> and their involvement in brain immune response against </b><b><i>Streptococcus agalactiae</i></b><b> infection”</b>

description: <i>Streptococcus agalactiae</i> (Group B <i>Streptococcus</i>) causes severe meningitis in tilapia (<i>Oreochromis niloticus</i>), leading to substantial economic losses in China. Toll-like receptors (TLRs), as pattern recognition receptors, play a pivotal role in innate immunity by helping the host defend against pathogenic threats. Despite their importance, a systematic characterization of TLR genes in tilapia has not been performed, and their response mechanisms in the brain remain poorly understood. In this study, we identified 19 TLR genes in the tilapia genome, including <i>TLR1-1</i>, <i>TLR1-2</i>, <i>TLR2-1</i>, <i>TLR2-2</i>, <i>TLR2-3</i>, <i>TLR2-4</i>, <i>TLR3</i>, <i>TLR5M</i>, <i>TLR5S</i>, <i>TLR7</i>, <i>TLR8-1</i>, <i>TLR8-2</i>, <i>TLR8-3</i>, <i>TLR9</i>, <i>TLR13-1</i>, <i>TLR13</i>-<i>2</i>, <i>TLR13-3</i>, <i>TLR18</i>, and <i>TLR22</i>. These genes contain conserved motifs typical of the TLR family and are distributed across 10 of the 22 chromosomes. Phylogenetic analysis classified these genes into five subfamilies: TLR1, TLR3, TLR5, TLR7, and TLR11, with the TLR4 subfamily absent. Integration of transcriptomic and single-cell data revealed that all 19 TLR genes are expressed across a variety of tissues and cells, with 14 of them (excluding <i>TLR1-1</i>, <i>TLR2-3</i>, <i>TLR5S</i>, <i>TLR13-2</i>, and<i> TLR13-3</i>) being expressed in the brain, particularly in the medulla oblongata. Furthermore, we examined the response of these 14 TLR genes to <i>S. agalactiae</i> infection in seven brain regions. Notably, <i>TLR1-2</i>, <i>TLR2-1</i>, <i>TLR5M,</i> <i>TLR8-1</i>, and<i> TLR13-1</i> were significantly upregulated in response to <i>S. agalactiae</i> infection, indicating their crucial role in the tilapia brain’s innate immune defense against <i>S. agalactiae</i>. These findings enhance our understanding of the TLR gene family in tilapia and its role in the brain’s immune response to bacterial invasion.