DOI: 10.5061/dryad.649nk
title: Data from: Activity patterns of serotonin neurons underlying cognitive flexibility

description: Serotonin is implicated in mood and affective disorders. However, growing
 evidence suggests that a core endogenous role is to promote flexible
 adaptation to changes in the causal structure of the environment, through
 behavioral inhibition and enhanced plasticity. We used long-term
 photometric recordings in mice to study a population of dorsal raphe
 serotonin neurons, whose activity we could link to normal reversal
 learning using pharmacogenetics. We found that these neurons are activated
 by both positive and negative prediction errors, and thus report signals
 similar to those proposed to promote learning in conditions of
 uncertainty. Furthermore, by comparing the cue responses of serotonin and
 dopamine neurons, we found differences in learning rates that could
 explain the importance of serotonin in inhibiting perseverative
 responding. Our findings show how the activity patterns of serotonin
 neurons support a role in cognitive flexibility, and suggest a revised
 model of dopamine–serotonin opponency with potential clinical
 implications.
description: Explanation of the data
 organization and characteristicsMatlab file containing
 summary information about each individual mouse used in the study, namely:
 in which experiment the mice were used (hM4D with reversals, photometry
 with reversal, photometry with surprise outcomes), to which group they
 belong (experimental or control, based on genotype, type of virus injected
 and drug received), list of the days considered for analysis, types of
 data collected (e.g. photometry, licking),information about how the
 individual day data files relate to the reversal day, some experimental
 conditions used in the photometry study.Data_info.mhf3_D10_alldatahM4Di experiment - mouse 10hf3_D11_alldatahM4Di experiment - mouse 11hf3_D12_alldatahM4Di experiment - mouse 12hf3_DR1_alldatahM4Di experiment - mouse 1hf3_DR2_alldatahM4Di experiment - mouse 2hf3_DR3_alldatahM4Di experiment - mouse 3hf3_DR4_alldatahM4Di experiment - mouse 4hf3_DR5_alldatahM4Di experiment - mouse 5hf3_DR6_alldatahM4Di experiment - mouse 6hf3_DR7_alldatahM4Di experiment - mouse 7hf3_DR8_alldatahM4Di experiment - mouse 8hf3_DR9_alldatahM4Di experiment - mouse 9hf3_MAX_alldataFiber photometry experiment - mouse MAXhf3_NEW_alldataFiber photometry experiment - mouse NEWhf3_OHM_alldataFiber photometry experiment - mouse OHMhf3_PAS_alldataFiber photometry experiment - mouse PAShf3_GAL_alldataFiber photometry experiment - mouse GALhf3_IDK_alldataFiber photometry experiment - mouse IDKhf3_KKK_alldataFiber photometry experiment - mouse KKKhf3_LAG_alldataFiber photometry experiment - mouse LAGhf3_ARC_alldataFiber photometry experiment - mouse ARC (YFP control)hf3_BOH_alldataFiber photometry experiment - mouse BOH (YFP control)hf3_QQQ_alldataFiber photometry experiment - mouse QQQ (YFP control)hf3_RIE_alldataFiber photometry experiment - mouse RIE (YFP control)hf3_NAS_alldataFiber photometry experiment - mouse NAS (TH-Cre mouse)hf3_ORE_alldataFiber photometry experiment - mouse ORE (TH-Cre mouse)hf3_POI_alldataFiber photometry experiment - mouse POI (TH-Cre mouse)hf6_GAL_alldataFiber photometry experiment - mouse GAL (surprise outcome task)hf6_IDK_alldataFiber photometry experiment - mouse IDK (surprise outcome task)hf6_KKK_alldataFiber photometry experiment - mouse KKK (surprise outcome task)hf6_LAG_alldataFiber photometry experiment - mouse LAG (surprise outcome task)hf6_NAS_alldataFiber photometry experiment - mouse NAS (surprise outcome task)hf6_ORE_alldataFiber photometry experiment - mouse ORE (surprise outcome task)hf6_POI_alldataFiber photometry experiment - mouse POI (surprise outcome task)