cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2st7s23
title: BindingDB Entry 50048997: Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.

description: Small molecule binding data for protein Dual specificity protein phosphatase 3, Leukocyte common antigen, Protein-tyrosine phosphatase 1B, and Tyrosine-protein phosphatase non-receptor type 2, Uniprot P08575, P17706, P18031, and P51452
DOI: 10.7270/q2vm4fdv
title: BindingDB Entry 50000142: Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 1/6, Histone deacetylase 2, Histone deacetylase 4, Histone deacetylase 8, Nicotinamide phosphoribosyltransferase, and Nuclear receptor corepressor 1, Uniprot A0A024QZ26, O75376, P43490, P56524, Q13547, Q92769, Q9BY41, and Q9UBN7
DOI: 10.7270/q2xk8hsd
title: BindingDB Entry 50048996: Discovery of phenyl acetamides as potent and selective GPR119 agonists.

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, Cytochrome P450 3A, Glucose-dependent insulinotropic receptor, and Pregnane X receptor (PXR), Uniprot O75469, P08684, P40989, Q7TQP3, and Q8TDV5
DOI: 10.7270/q21c2048
title: BindingDB Entry 50049003: Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity.

description: Small molecule binding data for protein Sigma non-opioid intracellular receptor 1 and Sigma-2 receptor, Uniprot Q5U3Y7 and Q60492
DOI: 10.7270/q2348nj0
title: BindingDB Entry 50000148: Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.

description: Small molecule binding data for protein MDM2-MDMX and p53-Binding Protein HDMX
DOI: 10.7270/q2542qv6
title: BindingDB Entry 50049002: Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

description: Small molecule binding data for protein Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A, Lysyl oxidase, Lysyl oxidase homolog 2, and Lysyl oxidase homolog 3, Uniprot B5DF27, P08684, P10635, P11712, P28300, P58022, P58215, and Q9Y4K0
DOI: 10.7270/q26w9d7z
title: BindingDB Entry 50000147: Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.

description: Small molecule binding data for protein Transthyretin, Uniprot P02766
DOI: 10.7270/q27w6ff7
title: BindingDB Entry 50049009: Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.

description: Small molecule binding data for protein Epidermal growth factor receptor, Platelet-derived growth factor receptor beta, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot P00533, P09619, and P35968
DOI: 10.7270/q28w3gkm
title: BindingDB Entry 50049001: Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.

description: Small molecule binding data for protein 20S proteasome chymotrypsin-like, 26S proteosome, Proteasome Macropain subunit, Proteasome component C5, Proteasome subunit beta type-10, and Proteasome subunit beta type-9, Uniprot P20618, P28062, P28065, P28074, P40306, and P49721
DOI: 10.7270/q2bp04zt
title: BindingDB Entry 50000146: Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design.

description: Small molecule binding data for protein BRD4/HDAC1, Uniprot O60885
DOI: 10.7270/q2cn765z
title: BindingDB Entry 50049008: Magnetic Microbead Affinity Selection Screening (MagMASS) of Botanical Extracts for Inhibitors of 15-Lipoxygenase.

description: Small molecule binding data for protein Arachidonate 15-lipoxygenase, Uniprot P16050
DOI: 10.7270/q2dn479b
title: BindingDB Entry 50049000: Pyrano[2,3,4-

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A (5-HT1A), 5-hydroxytryptamine receptor 2A, D(2) dopamine receptor, and Serotonin (5-HT) receptor, Uniprot P08908, P14416, P34969, and P50406
DOI: 10.7270/q2jd5012
title: BindingDB Entry 50048999: Comparison of the anion inhibition profiles of theß- and¿-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei.

description: Small molecule binding data for protein Carbonic anhydrase 1 and Carbonic anhydrase 2, Uniprot P00915 and P00918
DOI: 10.7270/q2k64m72
title: BindingDB Entry 50000153: Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.

description: Small molecule binding data for protein Heat shock protein HSP90, Uniprot P07900
DOI: 10.7270/q2n58pk5
title: BindingDB Entry 50049006: Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.

description: Small molecule binding data for protein Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase pim-2, and Serine/threonine-protein kinase pim-3, Uniprot P11309 and Q86V86
DOI: 10.7270/q2qv3pnp
title: BindingDB Entry 50000143: Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1).

description: Small molecule binding data for protein Transient receptor potential cation channel subfamily V member 1 and Vanilloid receptor, Uniprot O35433 and Q8NER1
DOI: 10.7270/q2rv0qz9
title: BindingDB Entry 50049005: Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.

description: Small molecule binding data for protein Mast/stem cell growth factor receptor Kit, Neurotrophic tyrosine kinase receptor, and Tyrosine-protein kinase receptor FLT3, Uniprot P10721, P36888, and Q16288
DOI: 10.7270/q2tm7d8g
title: BindingDB Entry 50000150: Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program.

description: Small molecule binding data for protein EZH2/SUZ12/EED/RBBP7/RBBP4, Uniprot O75530
DOI: 10.7270/q2wm1gnk
title: BindingDB Entry 50049004: Similarity- and Substructure-Based Development ofß

description: Small molecule binding data for protein Adrenergic receptor and Beta-2 adrenergic receptor and beta-3 adrenergic receptor, Uniprot P07550 and P08588
DOI: 10.7270/q2zc851n
title: BindingDB Entry 50000149: Nanomolar Inhibitors of Glycogen Phosphorylase Based onβ-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.

description: Small molecule binding data for protein Glycogen phosphorylase, muscle form and Liver glycogen phosphorylase, Uniprot P00489
DOI: 10.7270/q20c4z0h
title: BindingDB Entry 50049011: Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

description: Small molecule binding data for protein Tyrosyl-DNA phosphodiesterase 1, Uniprot Q9NUW8
DOI: 10.7270/q2251mb8
title: BindingDB Entry 50000159: Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

description: Small molecule binding data for protein Adenosine receptor, BRD4/HDAC1, Bromodomain adjacent to zinc finger domain protein 2A, Bromodomain adjacent to zinc finger domain protein 2B, Bromodomain and PHD finger-containing protein 3, Bromodomain and WD repeat-containing protein 1, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 7, Bromodomain-containing protein 8, Bromodomain-containing protein 9, Cat eye syndrome critical region protein 2, E3 ubiquitin-protein ligase TRIM33, Histone acetyltransferase KAT2A/KAT2B, Histone acetyltransferase p300/Hypoxia-inducible factor 1-alpha, Peregrin, Protein polybromo-1, Transcription activator BRG1, Transcription initiation factor TFIID subunit 1-like, Transcription intermediary factor 1-alpha, and Translocator protein, Uniprot O15164, O60885, P25440, P29275, P30536, P51532, P55201, Q09472, Q15059, Q58F21, Q86U86, Q8IZX4, Q92830, Q92831, Q9BXF3, Q9H0E9, Q9H8M2, Q9NPI1, Q9NSI6, Q9UIF8, Q9UIF9, Q9ULD4, and Q9UPN9
DOI: 10.7270/q2445pqt
title: BindingDB Entry 50049010: An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors.

description: Small molecule binding data for protein Fibroblast growth factor receptor, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor beta, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase receptor FLT3, Vascular endothelial growth factor receptor 1, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot L7RSL3, P00519, P07333, P07948, P09619, P10721, P11362, P16092, P17948, P21802, P22455, P22607, P35916, P35968, and P36888
DOI: 10.7270/q25x2c34
title: BindingDB Entry 50000157: In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.

description: Small molecule binding data for protein Mitogen-activated protein kinase 14, SRC, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Lyn, and Tyrosine-protein kinase TEC, Uniprot P06239, P06241, P07948, P42680, P51813, and Q06187
DOI: 10.7270/q26w9d9v
title: BindingDB Entry 50049017: New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking.

description: Small molecule binding data for protein Cannabinoid receptor 1 and Cannabinoid receptor 2, Uniprot P21554 and P34972
DOI: 10.7270/q29p33tf
title: BindingDB Entry 50000156: Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y

description: Small molecule binding data for protein Purinergic receptor P2Y2, Uniprot P41231
DOI: 10.7270/q2bp0514
title: BindingDB Entry 50049016: Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

description: Small molecule binding data for protein Pyruvate dehydrogenase kinase 3 (PDK3), Pyruvate dehydrogenase kinase 4 (PDK4), Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), and Pyruvate dehydrogenase kinase isoform 2 (PDHK2), Uniprot Q15118, Q15119, Q15120, and Q16654
DOI: 10.7270/q2ff3vjs
title: BindingDB Entry 50000155: Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

description: Small molecule binding data for protein DNA repair protein complementing XP-A cells, Uniprot P23025
DOI: 10.7270/q2gf0wr2
title: BindingDB Entry 50049015: Discovery of new nanomolar inhibitors of GPa: Extension of 2-oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors.

description: Small molecule binding data for protein Glycogen phosphorylase, muscle form, Uniprot P09812
DOI: 10.7270/q2hd7xww
title: BindingDB Entry 50049007: Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, Neurokinin 2 receptor, Neuromedin-K receptor, Pregnane X receptor (PXR), Short transient receptor potential channel 3, Short transient receptor potential channel 6, Sodium channel protein type 5 subunit alpha, Transient receptor potential cation channel subfamily A member 1, Transient receptor potential cation channel subfamily M member 8 (TRPM8), Transient receptor potential cation channel subfamily V member 1, Transient receptor potential cation channel subfamily V member 4, Vanilloid receptor, and Voltage-gated calcium channel, Uniprot O75469, O75762, P21452, P29371, P40989, Q13507, Q13936, Q14524, Q7Z2W7, Q8NER1, Q9EPK8, Q9ERZ8, Q9HBA0, and Q9Y210
DOI: 10.7270/q2j67k3p
title: BindingDB Entry 50000164: Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease.

description: Small molecule binding data for protein 3',5'-cyclic phosphodiesterase and Phosphodiesterase 6C (PDE6C), Uniprot O76074 and P51160
DOI: 10.7270/q2m61nh7
title: BindingDB Entry 50049014: Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

description: Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, Cytochrome P450 1A, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, and Cytochrome P450 3A, Uniprot P05177, P08684, P10635, P11712, P33261, and P40989
DOI: 10.7270/q2nz89s7
title: BindingDB Entry 50000163: Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.

description: Small molecule binding data for protein Aldehyde reductase, Aldo-keto reductase family 1 member C1, Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C4 (AK1C4), Aldo-keto reductase family member 1B10 (AKR1B10), Aldo-keto-reductase family 1 member C3, Aldose reductase, and Carbonyl reductase [NADPH] 1, Uniprot O60218, P14550, P15121, P16152, P17516, P42330, and P52895
DOI: 10.7270/q2pv6njr
title: BindingDB Entry 50000152: Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.

description: Small molecule binding data for protein MutT homolog 1 protein (MTH1), Uniprot P36639
DOI: 10.7270/q2qz2d66
title: BindingDB Entry 50049013: Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists.

description: Small molecule binding data for protein Glycine receptor (alpha-1/beta), Glycine receptor subunit alpha-1, and Glycine, non-strychnine, Uniprot P07727, P23415, and P48167
DOI: 10.7270/q2sn0c4n
title: BindingDB Entry 50000162: Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action.

description: Small molecule binding data for protein Vitamin D3 receptor, Uniprot P11473
DOI: 10.7270/q2vm4fh6
title: BindingDB Entry 50049012: Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.

description: Small molecule binding data for protein D-3-phosphoglycerate dehydrogenase, Uniprot O43175
DOI: 10.7270/q2xd13th
title: BindingDB Entry 50000161: Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

description: Small molecule binding data for protein Leucine--tRNA ligase, Leucyl-tRNA synthetase, and Probable leucine--tRNA ligase, mitochondrial, Uniprot P9WFV1, Q15031, and Q9P2J5
DOI: 10.7270/q2154k5f
title: BindingDB Entry 50000168: 4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 1/6, Histone deacetylase 2, Histone deacetylase 4, and Histone deacetylase 8, Uniprot A0A024QZ26, P56524, Q13547, Q92769, Q9BY41, and Q9UBN7
DOI: 10.7270/q2348nmw
title: BindingDB Entry 50049018: Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database.

description: Small molecule binding data for protein Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha, Uniprot P19793
DOI: 10.7270/q23x88sh
title: BindingDB Entry 50000183: Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.

description: Small molecule binding data for protein Focal adhesion kinase 1 and PTK2B protein tyrosine kinase 2 beta (PTK2B), Uniprot Q05397 and Q14289
DOI: 10.7270/q24x59xw
title: BindingDB Entry 50000167: Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential.

description: Small molecule binding data for protein CDK19/Cyclin C, Cyclin-C, and Cyclin-dependent kinase 8, Uniprot P24863
DOI: 10.7270/q25x2c51
title: BindingDB Entry 50049025: Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway.

description: Small molecule binding data for protein Smoothened homolog, Uniprot P56726
DOI: 10.7270/q28p62p2
title: BindingDB Entry 50000166: Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.

description: Small molecule binding data for protein PKC alpha and beta-2, Protein kinase C, PKC; classical/novel, and RAS guanyl-releasing protein 1, Uniprot O95267, P17252, and Q02156
DOI: 10.7270/q2df6tcz
title: BindingDB Entry 50000165: Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents.

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 1/6, and Histone deacetylase 2, Uniprot A0A024QZ26, Q13547, Q92769, and Q9UBN7
DOI: 10.7270/q2ff3vmp
title: BindingDB Entry 50049023: Selective Inhibitors of Human Liver Carboxylesterase Based on aß-Lapachone Scaffold: Novel Reagents for Reaction Profiling.

description: Small molecule binding data for protein Acyl-CoA: cholesterol acyltransferase (ACAT) and Carboxylesterase 2, Uniprot O00748 and P23141
DOI: 10.7270/q2h70j09
title: BindingDB Entry 50000173: Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.

description: Small molecule binding data for protein Acetylcholinesterase, Cholinesterase, and Cholinesterases; ACHE & BCHE, Uniprot O42275, P22303, and P81908
DOI: 10.7270/q2k64mbd
title: BindingDB Entry 50049022: Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.

description: Small molecule binding data for protein Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Lysophosphatidic acid receptor 1, Lysophosphatidic acid receptor 1/3, Lysophosphatidic acid receptor 4, Lysophosphatidic acid receptor 5 (LPA5), and Lysophosphatidic acid receptor Edg-4, Uniprot Q13822, Q92633, Q99677, Q9H1C0, Q9HBW0, and Q9UBY5
DOI: 10.7270/q2n018qm
title: BindingDB Entry 50000172: Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain.

description: Small molecule binding data for protein Vitamin D3 receptor A, Uniprot Q9PTN2
DOI: 10.7270/q2pz5c38
title: BindingDB Entry 50049021: Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors.

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 3, Histone deacetylase 6, and Histone deacetylase 8, Uniprot A0A024QZ26, O15379, Q13547, Q9BY41, and Q9UBN7
DOI: 10.7270/q2rr21dk
title: BindingDB Entry 50000170: Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

description: Small molecule binding data for protein Rap guanine nucleotide exchange factor 3 and Rap guanine nucleotide exchange factor 4, Uniprot O95398 and Q9EQZ6
DOI: 10.7270/q2tq63s4
title: BindingDB Entry 50049020: Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277.

description: Small molecule binding data for protein Activin receptor type-1, Activin receptor type-1B, Activin receptor-like kinase 3 (ALK-3), Bone morphogenetic protein receptor type-1B (BMPR1B), Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase; MEK1/2, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Serine/threonine-protein kinase receptor R3, TGF-beta receptor type I, Tyrosine-protein kinase receptor FLT3, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O00238, P35916, P35968, P36507, P36888, P36894, P36896, P37023, P52564, and Q04771
DOI: 10.7270/q2wd42qk
title: BindingDB Entry 50000169: Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.

description: Small molecule binding data for protein Protein-tyrosine phosphatase 1B, Tyrosine-protein phosphatase non-receptor type 11, and Tyrosine-protein phosphatase non-receptor type 2, Uniprot P17706, P18031, and Q06124
DOI: 10.7270/q2zc8540
title: BindingDB Entry 50049019: Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

description: Small molecule binding data for protein Cystic fibrosis transmembrane conductance regulator, Uniprot P13569
DOI: 10.7270/q2057j3z
title: BindingDB Entry 50000184: Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 1/2/3, Histone deacetylase 1/6, Histone deacetylase 2, Histone deacetylase 4, and Histone deacetylase 8, Uniprot A0A024QZ26, O15379, P56524, Q13547, Q92769, Q9BY41, and Q9UBN7
DOI: 10.7270/q2251mfm
title: BindingDB Entry 50049026: Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.

description: Small molecule binding data for protein Nucleoside diphosphate kinase B, Uniprot P22392
DOI: 10.7270/q26q20dv
title: BindingDB Entry 50048266: Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A

description: Small molecule binding data for protein Adenosine receptor A1, Adenosine receptor A2a, and Adenosine receptor A2b, Uniprot P29274, P29275, and P30542
DOI: 10.7270/q27p91jp
title: BindingDB Entry 50000181: Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.

description: Small molecule binding data for protein Epidermal growth factor receptor, Hepatocyte growth factor receptor, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase receptor Ret , Tyrosine-protein kinase receptor FLT3, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot P00533, P07949, P08581, P10721, P16234, P35968, and P36888
DOI: 10.7270/q28p62rz
title: BindingDB Entry 50049032: Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

description: Small molecule binding data for protein Prostaglandin E synthase, Uniprot O14684
DOI: 10.7270/q29p33wb
title: BindingDB Entry 50049024: Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.

description: Small molecule binding data for protein Estrogen receptor, Uniprot P03372