cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11847339.v1
title: Two-/three-dimensional coordination polymers: structural characterization and treatment activity on ulcerative colitis by regulating inflammatory cytokines

description: In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L<sub>1</sub>)<sub>0.5</sub>(oba)·DMF]·DMF·H<sub>2</sub>O} (<b>1</b>, L<sub>1</sub> = <i>N</i>,<i>N</i>′-bis(4-pyridylmethyl)-naphthalene diimide, H<sub>2</sub>oba = 4,4′-oxydibenzoic acid) and [Co(L<sub>2</sub>)<sub>0.5</sub>(OBA)]<i><sub>n</sub></i> (<b>2</b>, L<sub>2</sub> = 1,6-bis(benzimidazolyl)hexane) have been successfully synthesized by the solvothermal reaction of H<sub>2</sub>oba with different flexible N-donor organic ligands in the presence of Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O as the metal source. In addition, the biological functional evaluation of the complexes was performed on the ulcerative colitis (UC) model. First, the enzyme-linked immunosorbent assay detection kit was performed to measure the content of the pro-inflammatory cytokines and anti-inflammatory cytokines after complexes treatment. Next, the UC mice model was constructed and the body weight of the mice was measured and recorded at the 7th and 14th day after complexes treatment at the concentration of 5 mg/kg.
DOI: 10.6084/m9.figshare.14992991.v1
title: Additional file 8 of Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis

description: Additional file 8: Table S4. The key target genes of miR-144 in lung I/R injury selected according to the co-expression score.
DOI: 10.6084/m9.figshare.14992991
title: Additional file 8 of Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis

description: Additional file 8: Table S4. The key target genes of miR-144 in lung I/R injury selected according to the co-expression score.
DOI: 10.6084/m9.figshare.12896065
title: Metal ion-directed assembly of two mixed-ligand coordination polymers: treatment effect on acute kidney injury by reducing urine Nagl content

description: In the current study, two new transition metal-organic coordination polymers (CPs) with the chemical formula of [Cu(L)(OBA)(H<sub>2</sub>O)]<sub>n</sub> (<b>1</b>) and [Co(L)(OBA)]<sub>n</sub> (<b>2</b>) (H<sub>2</sub>OBA = 4,4(L)(OBA)]dy, two new traL = 1,4-bis(benzimidazol-1-yl)-2-butylene) were synthesized under solvothermal reaction conditions by using different metal centers as the nodes, which results in the structural differences in the as-prepared products although the same organic ligands are used. For the acute kidney injury treatment, their treatment activity on the acute kidney injury was evaluated and the related mechanism was explored at the same time. First of all, the ELISA detection kit was performed to determine the content of the neutrophil gelatinase-associated lipocalin (Nagl) in the urine after compounds <b>1</b> and <b>2</b> treatment. Besides, the real-time RT-PCR was conducted and the relative expression of the <i>jak</i> and <i>stat</i> in the glomerular epithelial cells was measured as well.
DOI: 10.6084/m9.figshare.19711698.v1
title: Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis

description: Astragaloside IV (AS-IV) is a bioactive saponin extracted from the Astragalus root and has been reported to exert a protective effect on diabetic nephropathy (DN). However, the underlying mechanism remains unclear. Herein, we found that AS-IV treatment alleviated DN symptoms in DN mice accompanied by reduced metabolic parameters (body weight, urine microalbumin and creatinine, creatinine clearance, and serum urea nitrogen and creatinine), pathological changes, and apoptosis. Epigenetic histone modifications are closely related to diabetes and its complications, including H3 lysine 4 monomethylation (H3K4me1, a promoter of gene transcription). A ChIP-seq assay was conducted to identify the genes regulated by H3K4me1 in DN mice after AS-IV treatment and followed by a Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. The results showed that there were 16 common genes targeted by H3K4me1 in normal and AS-IV-treated DN mice, 1148 genes were targeted by H3K4me1 only in DN mice. From the 1148 genes, we screened mitogen-activating protein kinase kinase kinase kinase-3 (MAP4K3) for the verification of gene expression and functional study. The results showed that MAP4K3 was significantly increased in DN mice and high glucose (HG)-treated NRK-52E cells, which was reversed by AS-IV. MAP4K3 silencing reduced the apoptosis of NRK-52E cells under HG condition, as evidenced by decreased cleaved caspase 3 and Bax (pro-apoptotic factors), and increased Bcl-2 and Bcl-xl (anti-apoptotic factors). Collectively, AS-IV may downregulate MAP4K3 expression by regulating H3K4me1 binding and further reducing apoptosis, which may be one of the potential mechanisms that AS-IV plays a protective effect on DN.
DOI: 10.6084/m9.figshare.12896065.v1
title: Metal ion-directed assembly of two mixed-ligand coordination polymers: treatment effect on acute kidney injury by reducing urine Nagl content

description: In the current study, two new transition metal-organic coordination polymers (CPs) with the chemical formula of [Cu(L)(OBA)(H<sub>2</sub>O)]<sub>n</sub> (<b>1</b>) and [Co(L)(OBA)]<sub>n</sub> (<b>2</b>) (H<sub>2</sub>OBA = 4,4(L)(OBA)]dy, two new traL = 1,4-bis(benzimidazol-1-yl)-2-butylene) were synthesized under solvothermal reaction conditions by using different metal centers as the nodes, which results in the structural differences in the as-prepared products although the same organic ligands are used. For the acute kidney injury treatment, their treatment activity on the acute kidney injury was evaluated and the related mechanism was explored at the same time. First of all, the ELISA detection kit was performed to determine the content of the neutrophil gelatinase-associated lipocalin (Nagl) in the urine after compounds <b>1</b> and <b>2</b> treatment. Besides, the real-time RT-PCR was conducted and the relative expression of the <i>jak</i> and <i>stat</i> in the glomerular epithelial cells was measured as well.
DOI: 10.6084/m9.figshare.16566129.v1
title: Donor cell leukemia/myelodysplastic syndrome after allogeneic stem cell transplantation: a rare phenomenon with more challenges for hematologists

description: Donor cell leukemia (DCL) or Donor cell myelodysplastic syndrome (DC-MDS) is a rare type of leukemia or MDS and originates from the donor cells. It has very low frequency, but it seems to be steadily increasing as the physiopathology and mechanisms remain largely unknown. Here we report one case of acute lymphocytic leukemia (ALL) and one case of MDS of donor origin after allogeneic hematopoietic stem cell transplantation (HSCT). We also collated and reviewed literatures regarding DCL, and discuss the morbidity of DCL, the methods used to confirm donor origin and the etiology and pathogenesis of DCL. A new proposed theory will help us to better understand the mechanism for the oncogenesis of DCL.
DOI: 10.6084/m9.figshare.6080219.v1
title: LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation

description: LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet well-understood. In this study, we evaluated the expression levels of LINP1 in tumor tissues and cell lines of cervical cancer. We found that LINP1 associates with NHEJ proteins (Ku80 and DNA-PKcs). LINP1 translocates from cytosol to nucleus in response to irradiation. In addition, LINP1 knockdown significantly increases the levels of cleaved caspase3 and PARP, leading to enhanced cell apoptosis after ionizing radiation (IR). LINP1-knockdown cells showed delayed repairs of DNA double-strand breaks (DSBs) after IR. Finally, LINP1 knockdown increases radiosensitivity of Hela S3 cells. These results suggest that LINP1 facilitates DSBs repair through NHEJ pathway and may thus serve as a prognostic marker and a potential target for the therapy of cervical cancer.
DOI: 10.6084/m9.figshare.14130173
title: Different DNA methylation regions profile in fetal cardiac defect cases compared to normal controls

description: In isolated cardiac defect cases, we tested 835 DMRs (Supplementary Table 5). In non-isolated cardiac defects, we tested 711 DMRs (Supplementary Table 6). After combining isolated and non-isolated cardiac defect cases, we identified global hypomethylation alteration, at a genome-wide level, with 1186 DMRs (Supplementary Table 7) compared to those in control samples.<br><br>
DOI: 10.6084/m9.figshare.16566129
title: Donor cell leukemia/myelodysplastic syndrome after allogeneic stem cell transplantation: a rare phenomenon with more challenges for hematologists

description: Donor cell leukemia (DCL) or Donor cell myelodysplastic syndrome (DC-MDS) is a rare type of leukemia or MDS and originates from the donor cells. It has very low frequency, but it seems to be steadily increasing as the physiopathology and mechanisms remain largely unknown. Here we report one case of acute lymphocytic leukemia (ALL) and one case of MDS of donor origin after allogeneic hematopoietic stem cell transplantation (HSCT). We also collated and reviewed literatures regarding DCL, and discuss the morbidity of DCL, the methods used to confirm donor origin and the etiology and pathogenesis of DCL. A new proposed theory will help us to better understand the mechanism for the oncogenesis of DCL.
DOI: 10.6084/m9.figshare.6080219
title: LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation

description: LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet well-understood. In this study, we evaluated the expression levels of LINP1 in tumor tissues and cell lines of cervical cancer. We found that LINP1 associates with NHEJ proteins (Ku80 and DNA-PKcs). LINP1 translocates from cytosol to nucleus in response to irradiation. In addition, LINP1 knockdown significantly increases the levels of cleaved caspase3 and PARP, leading to enhanced cell apoptosis after ionizing radiation (IR). LINP1-knockdown cells showed delayed repairs of DNA double-strand breaks (DSBs) after IR. Finally, LINP1 knockdown increases radiosensitivity of Hela S3 cells. These results suggest that LINP1 facilitates DSBs repair through NHEJ pathway and may thus serve as a prognostic marker and a potential target for the therapy of cervical cancer.
DOI: 10.6084/m9.figshare.17090798
title: miR‐30a‐3p inhibits the proliferation of laryngeal cancer cells by targeting DNMT3a through regulating DNA methylation of PTEN

description: CCK8、qPCR、Dual-Luciferase<br>
DOI: 10.6084/m9.figshare.14993646
title: Datafile S9. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 17 kingdom-level clades based on high projected species numbers
DOI: 10.6084/m9.figshare.14993652
title: Datafile S8. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 17 kingdom-level clades based on low projected species numbers
DOI: 10.6084/m9.figshare.14993655
title: Datafile S6. from Multicellularity and sex helped shape the Tree of Life

description: Tree for 31 clades
DOI: 10.6084/m9.figshare.14993658
title: Datafile S2. from Multicellularity and sex helped shape the Tree of Life

description: Data on multicellularity and sexual reproduction within 15 kingdom-level clades
DOI: 10.6084/m9.figshare.14993661
title: Datafile S5. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 17 kingdom-level clades based on described species richness.
DOI: 10.6084/m9.figshare.14993664
title: Datafile S1. from Multicellularity and sex helped shape the Tree of Life

description: Tree for 17 kingdom-level clades
DOI: 10.6084/m9.figshare.14993667
title: Datafile S10. from Multicellularity and sex helped shape the Tree of Life

description: Summary data for 31 clades
DOI: 10.6084/m9.figshare.14993670
title: Datafile S7. from Multicellularity and sex helped shape the Tree of Life

description: Tree for 15 kingdom-level eukaryote clades
DOI: 10.6084/m9.figshare.14993673
title: Datafile S3. from Multicellularity and sex helped shape the Tree of Life

description: Estimated frequencies of multicellularity and sexual reproduction within phyla.
DOI: 10.6084/m9.figshare.14993020.v1
title: Additional file 8 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S7, Motif analysis of Khib modified peptides.
DOI: 10.6084/m9.figshare.14993020
title: Additional file 8 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S7, Motif analysis of Khib modified peptides.
DOI: 10.6084/m9.figshare.14993002
title: Additional file 2 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S1, All identified Khib-modified peptides and proteins in rhubarb.
DOI: 10.6084/m9.figshare.14993005.v1
title: Additional file 3 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S2, GO functional classification of Khib-modified proteins.
DOI: 10.6084/m9.figshare.14993008.v1
title: Additional file 4 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S3, Classification of subcellular localizations of Khib-modified proteins.
DOI: 10.6084/m9.figshare.25233040
title: Material Complementario BH

description: Este conjunto de datos contiene material complementario.
DOI: 10.6084/m9.figshare.25233040.v1
title: Material Complementario BH

description: Este conjunto de datos contiene material complementario.
DOI: 10.6084/m9.figshare.21809523
title: Leveraging what you know: Versatile space-filling designs

description: Space-filling designs continue to gain popularity for computer experiments. Uniformity of space-filling characteristics has been broadly sought after to provide good estimation and prediction abilities for a variety of complex models. This article presents case studies when additional information on the features of the underlying relationship may be leveraged for selecting alternative space-filling designs that offer improvements to meet specific experimental goals. Three types of nontraditional space-filling designs are illustrated to achieve different objectives to (1) allow varied density of design points across the input space, (2) obtain balanced performance on covering the input space and the range of the response values, and (3) effectively augment existing runs to achieve certain space-filling characteristic in a sequential experiment. The mechanics for implementing these design choices are described and their flexibility to adapt to other experimental scenarios is illustrated.
DOI: 10.6084/m9.figshare.21809523.v1
title: Leveraging what you know: Versatile space-filling designs

description: Space-filling designs continue to gain popularity for computer experiments. Uniformity of space-filling characteristics has been broadly sought after to provide good estimation and prediction abilities for a variety of complex models. This article presents case studies when additional information on the features of the underlying relationship may be leveraged for selecting alternative space-filling designs that offer improvements to meet specific experimental goals. Three types of nontraditional space-filling designs are illustrated to achieve different objectives to (1) allow varied density of design points across the input space, (2) obtain balanced performance on covering the input space and the range of the response values, and (3) effectively augment existing runs to achieve certain space-filling characteristic in a sequential experiment. The mechanics for implementing these design choices are described and their flexibility to adapt to other experimental scenarios is illustrated.
DOI: 10.6084/m9.figshare.24955269
title: Data.zip

description: The purpose of this study was to evaluate and compare the swallow-related muscles and bones movement patterns during swallowing quantitatively by B+M-mode ultrasound, and to investigate its application value in dysphagia. Stroke patients with dysphagia (patients group) and sixty healthy elderly people (control group) were selectedin this study. M mode-ultrasound was used to detect parameters were compared between the two groups.
DOI: 10.6084/m9.figshare.24955279
title: Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line

description: The prevalence of alcohol-related hepatocellular carcinoma (HCC) has been increasing during the last decade. Cancer research requires cell lines suitable for both <i>in vitro</i> and <i>in vivo</i> assays. However, there is a lack of cell lines with a high <i>in vivo</i> metastatic capacity for this HCC subtype. Herein, a new HCC cell line was established, named HCC-ZJ, using cells from a patient diagnosed with alcohol-related HCC. The karyotype of HCC-ZJ was 46, XY, del (p11.2). Whole-exome sequencing identified several genetic variations in HCC-Z that occur frequently in alcohol-associated HCC, such as mutations in <i>TERT</i>, <i>CTNNB1</i>, <i>ARID1A</i>, <i>CDKN2A</i>, <i>SMARCA2</i>, and <i>HGF</i>. Cell counting kit-8 assays, colony formation assays, and Transwell assays were performed to evaluate the proliferation, migration, and sensitivity to sorafenib and lenvatinib of HCC-Z <i>in vitro</i>. HCC-ZJ showed a robust proliferation rate, a weak foci-forming ability, a strong migration capacity, and a moderate invasion tendency <i>in vitro</i>. Finally, the tumorigenicity and metastatic capacity of HCC-Z were evaluated using a subcutaneous xenograft model, an orthotopic xenograft model, and a tail-veil injection model. HCCZJ exhibited strong tumorigenicity in the subcutaneous xenograft and orthotopic tumor models. Moreover, HCC-ZJ spontaneously formed pulmonary metastases in the orthotopic tumor model. In summary, a new HCC cell line derived from a patient with alcohol-related HCC was established, which showed a high metastatic capacity and could be applied for <i>in vitro</i> and <i>in vivo</i> experiments during pre-clinical research. <b>Highlights</b> • An alcohol-related HCC cell line, HCC-ZJ, was established • HCC-ZJ was applicable for <i>in vitro</i> functional experiment and gene editing • HCC-ZJ was applicable for <i>in vivo</i> tumor growth and spontaneous metastasis models
DOI: 10.6084/m9.figshare.24955279.v1
title: Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line

description: The prevalence of alcohol-related hepatocellular carcinoma (HCC) has been increasing during the last decade. Cancer research requires cell lines suitable for both <i>in vitro</i> and <i>in vivo</i> assays. However, there is a lack of cell lines with a high <i>in vivo</i> metastatic capacity for this HCC subtype. Herein, a new HCC cell line was established, named HCC-ZJ, using cells from a patient diagnosed with alcohol-related HCC. The karyotype of HCC-ZJ was 46, XY, del (p11.2). Whole-exome sequencing identified several genetic variations in HCC-Z that occur frequently in alcohol-associated HCC, such as mutations in <i>TERT</i>, <i>CTNNB1</i>, <i>ARID1A</i>, <i>CDKN2A</i>, <i>SMARCA2</i>, and <i>HGF</i>. Cell counting kit-8 assays, colony formation assays, and Transwell assays were performed to evaluate the proliferation, migration, and sensitivity to sorafenib and lenvatinib of HCC-Z <i>in vitro</i>. HCC-ZJ showed a robust proliferation rate, a weak foci-forming ability, a strong migration capacity, and a moderate invasion tendency <i>in vitro</i>. Finally, the tumorigenicity and metastatic capacity of HCC-Z were evaluated using a subcutaneous xenograft model, an orthotopic xenograft model, and a tail-veil injection model. HCCZJ exhibited strong tumorigenicity in the subcutaneous xenograft and orthotopic tumor models. Moreover, HCC-ZJ spontaneously formed pulmonary metastases in the orthotopic tumor model. In summary, a new HCC cell line derived from a patient with alcohol-related HCC was established, which showed a high metastatic capacity and could be applied for <i>in vitro</i> and <i>in vivo</i> experiments during pre-clinical research. <b>Highlights</b> • An alcohol-related HCC cell line, HCC-ZJ, was established • HCC-ZJ was applicable for <i>in vitro</i> functional experiment and gene editing • HCC-ZJ was applicable for <i>in vivo</i> tumor growth and spontaneous metastasis models
DOI: 10.6084/m9.figshare.7252535
title: Triglyceride glucose and haemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study

description: <b>Aim:</b> Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined. <b>Methods:</b> We conducted a nested case-control study among 1282 T2DM patients with stable CAD. Patients were followed up for 3846 person-years. A total of 160 patients with events (12.5%) were identified and matched individually on age, gender, previous use of lipid lowering agents and duration of follow-up with 640 controls. <b>Results:</b> In Kaplan–Meier analysis, the upper tertiles of TyG index and HGI had a significant lower event-free survival (<i>p</i> = .002; <i>p</i> = .036, respectively). Of the note, both TyG index and HGI were associated with increased risk of MACCEs after adjusting for confounding risk factors [adjusted HR (95% CI): 1.693 (1.238–2.316); 1.215 (1.046–1.411), respectively]. Moreover, adding TyG index to the Cox model increased the C-statistic to 0.638 (95%CI: 0.595–0.683, <i>p</i> = .002) while the C-statistic was not statistically improved when HGI was included (<i>p</i> = .240). <b>Conclusions:</b> Both TyG index and HGI could predict cardiovascular outcomes in T2DM patients with new-onset, stable CAD while TyG index might be better.Key messagesBoth TyG and HGI are predictors of cardiovascular risk.The prognostic value of TyG index and HGI in T2DM patients with stable coronary artery disease is not determined.Our study firstly indicates that TyG index might have better prognostic value than HGI in T2DM patients with new-onset, stable CAD. Both TyG and HGI are predictors of cardiovascular risk. The prognostic value of TyG index and HGI in T2DM patients with stable coronary artery disease is not determined. Our study firstly indicates that TyG index might have better prognostic value than HGI in T2DM patients with new-onset, stable CAD.
DOI: 10.6084/m9.figshare.14993008
title: Additional file 4 of Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)

description: Table S3, Classification of subcellular localizations of Khib-modified proteins.