cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29555044
title: The use of Doppler velocimetry of the ophthalmic artery and the fullPIERS model to predict adverse outcomes in hospitalized pregnant women with preeclampsia: a prospective cohort study

description: To evaluate the role of Doppler ophthalmic artery (DOA) indices and fullPIERS score in predicting adverse maternal outcomes in pregnant women hospitalized for preeclampsia (PE). Prospective cohort study conducted in pregnant women with PE and signs of deterioration. All pregnant women with PE with signs of clinical deterioration and with target organ involvement were evaluated when hospitalized, between September 2019 and November 2022. DOA indices and fullPIERS score were performed and the main adverse outcomes were analyzed. Main outcome measures: Maternal hypertensive crises, injury of central nervous system, liver, kidney and other outcomes related to PE. Attending clinicians were blinded to the DOA results. We included 138 pregnant women and lost 13 cases prospectively. Maternal hypertensive crises, central nervous system injury, liver, kidney and other preeclampsia-related outcomes. Results: The AOD that demonstrated the best predictive effect of composite adverse outcomes in the study population was the second peak systolic velocity (P2), with a moderate effect when adopting a cutoff point of 21.2 cm/s (OR 3.04, 95% CI 1.45–6.33). P2 was able to correctly identify 70% of pregnant women with PE who progressed to composite adverse outcomes, with a false positive rate of 30%. The fullPIERS score was a weak predictor of adverse outcomes in pregnant women with PE. The peak systolic velocity, P2 and EDV obtained from the AOD, as well as the fullPIERS model, were able to predict adverse maternal outcomes in pregnant women hospitalized with PE. A P2 cutoff point ≥21.2 cm/s provided the best prediction for adverse maternal outcomes.
DOI: 10.6084/m9.figshare.29555044.v1
title: The use of Doppler velocimetry of the ophthalmic artery and the fullPIERS model to predict adverse outcomes in hospitalized pregnant women with preeclampsia: a prospective cohort study

description: To evaluate the role of Doppler ophthalmic artery (DOA) indices and fullPIERS score in predicting adverse maternal outcomes in pregnant women hospitalized for preeclampsia (PE). Prospective cohort study conducted in pregnant women with PE and signs of deterioration. All pregnant women with PE with signs of clinical deterioration and with target organ involvement were evaluated when hospitalized, between September 2019 and November 2022. DOA indices and fullPIERS score were performed and the main adverse outcomes were analyzed. Main outcome measures: Maternal hypertensive crises, injury of central nervous system, liver, kidney and other outcomes related to PE. Attending clinicians were blinded to the DOA results. We included 138 pregnant women and lost 13 cases prospectively. Maternal hypertensive crises, central nervous system injury, liver, kidney and other preeclampsia-related outcomes. Results: The AOD that demonstrated the best predictive effect of composite adverse outcomes in the study population was the second peak systolic velocity (P2), with a moderate effect when adopting a cutoff point of 21.2 cm/s (OR 3.04, 95% CI 1.45–6.33). P2 was able to correctly identify 70% of pregnant women with PE who progressed to composite adverse outcomes, with a false positive rate of 30%. The fullPIERS score was a weak predictor of adverse outcomes in pregnant women with PE. The peak systolic velocity, P2 and EDV obtained from the AOD, as well as the fullPIERS model, were able to predict adverse maternal outcomes in pregnant women hospitalized with PE. A P2 cutoff point ≥21.2 cm/s provided the best prediction for adverse maternal outcomes.
DOI: 10.13130/rd_unimi/ui9ecn/0i8ajh
title: Giugno_1880_Pagina_008.jpg

description: Bulletin of 1880/06/02
DOI: 10.13130/rd_unimi/ui9ecn/tgmoui
title: Giugno_1880_Pagina_009.jpg

description: Bulletin of 1880/06/03
DOI: 10.13130/rd_unimi/ui9ecn/ffrjjy
title: Giugno_1880_Pagina_010.jpg

description: Bulletin of 1880/06/03
DOI: 10.13130/rd_unimi/ui9ecn/k9d76h
title: Giugno_1880_Pagina_011.jpg

description: Bulletin of 1880/06/03
DOI: 10.13130/rd_unimi/ui9ecn/zdy35o
title: Giugno_1880_Pagina_012.jpg

description: Bulletin of 1880/06/03
DOI: 10.6084/m9.figshare.30661664
title: Establishment of a scoring system for vaginal delivery of twin pregnancies

description: To establish a scoring system for vaginal delivery of twin pregnancies. A retrospective cohort study was carried out on pregnant women carrying twins who were under systematic antenatal care and delivered at the Beijing Obstetrics and Gynecology Hospital from January 2017 to March 2019. Factors associated with the vaginal delivery of twins were compared between research (<i>n</i> = 96 successful vaginal deliveries) and comparison groups (<i>n</i> = 18 intrapartum cesarean deliveries). Five variables were included in the model. Models were developed and the score for each variable was given according to the multiple-factor regression analysis index and nomogram. The scores were: age of the mother &lt;35 y: 64; no gestational diabetes mellitus (GDM): 100, no insulin application in GDM: 47, and application of insulin: 0; appropriateness of weight gain during pregnancy: 82; parity ≥2: 58; and weight of the second fetus (Fetus2) less than the first (Fetus1): 57. The receiver operating characteristic (ROC) curve was plotted and the area under the curve (AUC) was 0.856 (95% CI: 0.783–0.929), the maximum value of the Youden index was 0.5647, and the corresponding score was 168, which yielded a sensitivity of 80.2% and a specificity of 76.3%. A scoring system guiding the selection of mode of delivery was established. The total score of the model was 361 and when the score was &gt;168, the success rate of a vaginal delivery increased significantly.
DOI: 10.6084/m9.figshare.30661664.v1
title: Establishment of a scoring system for vaginal delivery of twin pregnancies

description: To establish a scoring system for vaginal delivery of twin pregnancies. A retrospective cohort study was carried out on pregnant women carrying twins who were under systematic antenatal care and delivered at the Beijing Obstetrics and Gynecology Hospital from January 2017 to March 2019. Factors associated with the vaginal delivery of twins were compared between research (<i>n</i> = 96 successful vaginal deliveries) and comparison groups (<i>n</i> = 18 intrapartum cesarean deliveries). Five variables were included in the model. Models were developed and the score for each variable was given according to the multiple-factor regression analysis index and nomogram. The scores were: age of the mother &lt;35 y: 64; no gestational diabetes mellitus (GDM): 100, no insulin application in GDM: 47, and application of insulin: 0; appropriateness of weight gain during pregnancy: 82; parity ≥2: 58; and weight of the second fetus (Fetus2) less than the first (Fetus1): 57. The receiver operating characteristic (ROC) curve was plotted and the area under the curve (AUC) was 0.856 (95% CI: 0.783–0.929), the maximum value of the Youden index was 0.5647, and the corresponding score was 168, which yielded a sensitivity of 80.2% and a specificity of 76.3%. A scoring system guiding the selection of mode of delivery was established. The total score of the model was 361 and when the score was &gt;168, the success rate of a vaginal delivery increased significantly.
DOI: 10.13130/rd_unimi/ui9ecn/yhqwvi
title: Giugno_1880_Pagina_013.jpg

description: Bulletin of 1880/06/04
DOI: 10.6084/m9.figshare.28267303
title: Maternal and neonatal outcomes in pregnant women undergoing cardiac surgery: a systematic review and meta-analysis

description: Cardiac diseases that require surgical intervention present a unique challenge during pregnancy and may affect both maternal and neonatal outcomes. This systematic review and meta-analysis aimed to evaluate maternal and neonatal outcomes in pregnant females undergoing cardiac surgery. A comprehensive manual and electronic search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Sciences databases for studies published up to 31<sup>st</sup> May 2024. Eligible studies were required to report maternal and neonatal outcomes of women who underwent cardiac surgery during pregnancy. Random-effects meta-analysis was conducted to estimate pooled maternal and neonatal mortality proportions, and the results were presented as risk ratios (RR) with 95% confidence intervals (CIs). Seventeen studies met the inclusion criteria, comprising a total sample size of 196 pregnant women who underwent cardiac surgery. Cardiac surgery during pregnancy was significantly (<i>p</i> &lt; 0.001) linked to increased maternal and neonatal mortality, with pooled RR of 4.9% (CI: 2.1%−7.6%) and 26.5% (CI: 19.7%−33.4%), respectively. This study highlights the significant risks associated with cardiac surgery during pregnancy, such as increased risk of maternal and neonatal mortality and higher incidence of preterm labor. Our findings underscore the importance of specialized care and multidisciplinary management for pregnant women with cardiac conditions. Further research is warranted to identify strategies for risk mitigation and improved outcomes in this vulnerable population.
DOI: 10.6084/m9.figshare.28267303.v1
title: Maternal and neonatal outcomes in pregnant women undergoing cardiac surgery: a systematic review and meta-analysis

description: Cardiac diseases that require surgical intervention present a unique challenge during pregnancy and may affect both maternal and neonatal outcomes. This systematic review and meta-analysis aimed to evaluate maternal and neonatal outcomes in pregnant females undergoing cardiac surgery. A comprehensive manual and electronic search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Sciences databases for studies published up to 31<sup>st</sup> May 2024. Eligible studies were required to report maternal and neonatal outcomes of women who underwent cardiac surgery during pregnancy. Random-effects meta-analysis was conducted to estimate pooled maternal and neonatal mortality proportions, and the results were presented as risk ratios (RR) with 95% confidence intervals (CIs). Seventeen studies met the inclusion criteria, comprising a total sample size of 196 pregnant women who underwent cardiac surgery. Cardiac surgery during pregnancy was significantly (<i>p</i> &lt; 0.001) linked to increased maternal and neonatal mortality, with pooled RR of 4.9% (CI: 2.1%−7.6%) and 26.5% (CI: 19.7%−33.4%), respectively. This study highlights the significant risks associated with cardiac surgery during pregnancy, such as increased risk of maternal and neonatal mortality and higher incidence of preterm labor. Our findings underscore the importance of specialized care and multidisciplinary management for pregnant women with cardiac conditions. Further research is warranted to identify strategies for risk mitigation and improved outcomes in this vulnerable population.
DOI: 10.13130/rd_unimi/ui9ecn/pwboad
title: Giugno_1880_Pagina_014.jpg

description: Bulletin of 1880/06/04
DOI: 10.6084/m9.figshare.29095692
title: Genetic analysis and prenatal diagnosis of 15q11-q13 microduplication syndrome

description: 15q11-q13 microduplication syndrome, a genetic disorder caused by duplications in the 15q11-q13 region, has been associated with autism spectrum disorder (ASD); however, research on chromosome 15 microduplications is scarce. We explored the copy number variant (CNV) characteristics of 15q11-q13 microduplication syndrome, pathogenic mechanisms of ASD-related causative genes in this region, and factors affecting ASD development. We performed laboratory investigations and data collection on seven cases of 15q11-q13 microduplications, comprising 5 prenatal and 2 postnatal cases, detected using chromosomal microarray analysis (CMA), comparing their CNV characteristics and clinical presentations. Chromosomal karyotyping was not performed in one case, while the results for the others were normal. CMA revealed one case each of a microduplication at 15q11.2q13.3, 15q11.2, 15q13.2q13.3, 15q13.3, and three at 15q11.2q13.1, varying in size from 444 kb to 9.6 Mb. Of the seven confirmed cases, postnatal facial anomalies were present in two male patients (cases 5 and 6), with one exhibiting intellectual disability, speech delay, ASD features, and hypotonia. No significant abnormalities could be observed in the five female patients. Concerning the five prenatal cases, four exhibited an ultrasound testing suggestive of abnormality, one displayed no abnormality on the ultrasound, although the mother of the fetus had a history of adverse pregnancy outcomes. Finally, only case 5 displayed facial deformities after birth. The remaining four fetuses did not retain any abnormality during postnatal follow-up.” The 15q11-q13 region may be associated with an increased ASD risk, and its clinical phenotype may be related to sex. Our study presents detailed clinical features and molecular genetic data, providing important insights into the link between 15q duplications and ASD and diagnosing and treating the syndrome.
DOI: 10.6084/m9.figshare.29095692.v1
title: Genetic analysis and prenatal diagnosis of 15q11-q13 microduplication syndrome

description: 15q11-q13 microduplication syndrome, a genetic disorder caused by duplications in the 15q11-q13 region, has been associated with autism spectrum disorder (ASD); however, research on chromosome 15 microduplications is scarce. We explored the copy number variant (CNV) characteristics of 15q11-q13 microduplication syndrome, pathogenic mechanisms of ASD-related causative genes in this region, and factors affecting ASD development. We performed laboratory investigations and data collection on seven cases of 15q11-q13 microduplications, comprising 5 prenatal and 2 postnatal cases, detected using chromosomal microarray analysis (CMA), comparing their CNV characteristics and clinical presentations. Chromosomal karyotyping was not performed in one case, while the results for the others were normal. CMA revealed one case each of a microduplication at 15q11.2q13.3, 15q11.2, 15q13.2q13.3, 15q13.3, and three at 15q11.2q13.1, varying in size from 444 kb to 9.6 Mb. Of the seven confirmed cases, postnatal facial anomalies were present in two male patients (cases 5 and 6), with one exhibiting intellectual disability, speech delay, ASD features, and hypotonia. No significant abnormalities could be observed in the five female patients. Concerning the five prenatal cases, four exhibited an ultrasound testing suggestive of abnormality, one displayed no abnormality on the ultrasound, although the mother of the fetus had a history of adverse pregnancy outcomes. Finally, only case 5 displayed facial deformities after birth. The remaining four fetuses did not retain any abnormality during postnatal follow-up.” The 15q11-q13 region may be associated with an increased ASD risk, and its clinical phenotype may be related to sex. Our study presents detailed clinical features and molecular genetic data, providing important insights into the link between 15q duplications and ASD and diagnosing and treating the syndrome.
DOI: 10.6084/m9.figshare.29152117
title: Role of doubling rate of hCG in predicting early pregnancy loss: a retrospective analysis

description: This study aims to explore whether the human chorionic gonadotropin (hCG) doubling rate every 48 h (HDR) predicts early pregnancy outcomes in women with pregnancy loss. The early clinical pregnancy outcomes in 257 women with a history of pregnancy loss were analyzed in this retrospective study. The optimal cutoff value of HDR was determined by the receiver operating characteristic (ROC) curve and the Youden index. The primary outcome was pregnancy loss occurring before 12 weeks of gestation. A total of 257 patients were enrolled in this study. According to the pregnancy outcome at 12 weeks of gestation, the patients were divided into ongoing pregnancy (<i>N</i> = 198) and early pregnancy loss (EPL) groups (<i>N</i> = 59). In the total study population, the HDRs in ongoing pregnancy group were significantly higher than those in EPL group at specific intervals of hCG levels: 150–400 mIU/ml, 400–800 mIU/ml, and 3200–6400 mIU/ml. The corresponding thresholds were 1.855, 2.219, and 1.730, respectively (<i>p</i> &lt; 0.05). A similar result was observed among patients with recurrent pregnancy loss (RPL) across the intervals of 400–800 mIU/ml, 800–1600 mIU/ml, 3200–6400 mIU/ml, and 20000–30000 mIU/ml, with corresponding thresholds of 2.219, 1.812, 1.730, and 1.450, respectively. HDR may serve as an evaluative tool for predicting the risk of EPL in women with pregnancy loss. Differences in the intervals showing predictive value between women with and without RPL imply that individualized interpretation of HDR may be warranted in these subgroups. However, given the limited sample size, especially within the EPL group, these findings should be interpreted with caution.
DOI: 10.6084/m9.figshare.29152117.v1
title: Role of doubling rate of hCG in predicting early pregnancy loss: a retrospective analysis

description: This study aims to explore whether the human chorionic gonadotropin (hCG) doubling rate every 48 h (HDR) predicts early pregnancy outcomes in women with pregnancy loss. The early clinical pregnancy outcomes in 257 women with a history of pregnancy loss were analyzed in this retrospective study. The optimal cutoff value of HDR was determined by the receiver operating characteristic (ROC) curve and the Youden index. The primary outcome was pregnancy loss occurring before 12 weeks of gestation. A total of 257 patients were enrolled in this study. According to the pregnancy outcome at 12 weeks of gestation, the patients were divided into ongoing pregnancy (<i>N</i> = 198) and early pregnancy loss (EPL) groups (<i>N</i> = 59). In the total study population, the HDRs in ongoing pregnancy group were significantly higher than those in EPL group at specific intervals of hCG levels: 150–400 mIU/ml, 400–800 mIU/ml, and 3200–6400 mIU/ml. The corresponding thresholds were 1.855, 2.219, and 1.730, respectively (<i>p</i> &lt; 0.05). A similar result was observed among patients with recurrent pregnancy loss (RPL) across the intervals of 400–800 mIU/ml, 800–1600 mIU/ml, 3200–6400 mIU/ml, and 20000–30000 mIU/ml, with corresponding thresholds of 2.219, 1.812, 1.730, and 1.450, respectively. HDR may serve as an evaluative tool for predicting the risk of EPL in women with pregnancy loss. Differences in the intervals showing predictive value between women with and without RPL imply that individualized interpretation of HDR may be warranted in these subgroups. However, given the limited sample size, especially within the EPL group, these findings should be interpreted with caution.
DOI: 10.13130/rd_unimi/ui9ecn/0z02mg
title: Giugno_1880_Pagina_015.jpg

description: Bulletin of 1880/06/04
DOI: 10.13130/rd_unimi/ui9ecn/xi2vvp
title: Giugno_1880_Pagina_016.jpg

description: Bulletin of 1880/06/04
DOI: 10.6084/m9.figshare.29396320
title: Postpartum hemorrhage and long-term cardiovascular disease risk: a comprehensive systematic review and meta-analysis

description: <b>Purpose:</b> Postpartum hemorrhage (PPH) is a major contributor to maternal morbidity and mortality and may have long-term consequences on cardiovascular health. This systematic review and meta-analysis aimed to evaluate the association between PPH and the subsequent risk of cardiovascular disease (CVD) in women. <b>Materials and methods:</b> A comprehensive literature search was conducted across major databases to identify cohort studies assessing cardiovascular outcomes in women with a history of PPH. Data from over 9.7 million participants were pooled using a random-effects model to account for inter-study heterogeneity. The primary outcomes included cardiovascular diseases and thromboembolism events. Subgroup analyses were conducted separately for cardiovascular and thromboembolism outcomes. Sensitivity analyses were conducted to examine the consistency and robustness of the pooled estimates. <b>Results:</b> Women with a history of PPH had a 1.76-fold increased risk of developing cardiovascular disease and 2.10-fold increased risk of thromboembolism. The risk was particularly elevated among those requiring transfusion. Cardiovascular risk was most frequent during the first year postpartum and persisted for up to 15 years, particularly among those with hypertensive disorders of pregnancy. Heterogeneity was substantial for cardiovascular disease outcome (<i>I</i><sup>²</sup>=99%) and moderate for thromboembolic outcomes (<i>I</i><sup>²</sup>=43%). Sensitivity analyses reduced heterogeneity for cardiovascular disease to 77.1%. <b>Conclusions:</b> PPH is associated with a significantly increased long-term risk of both cardiovascular and thromboembolism disease. These findings highlight the importance of postpartum cardiovascular risk screening and preventive interventions in women with a history of severe PPH. Future research should adopt standardized methodologies and focus on high-burden settings, particularly in low- and middle-income countries.
DOI: 10.6084/m9.figshare.29396320.v1
title: Postpartum hemorrhage and long-term cardiovascular disease risk: a comprehensive systematic review and meta-analysis

description: <b>Purpose:</b> Postpartum hemorrhage (PPH) is a major contributor to maternal morbidity and mortality and may have long-term consequences on cardiovascular health. This systematic review and meta-analysis aimed to evaluate the association between PPH and the subsequent risk of cardiovascular disease (CVD) in women. <b>Materials and methods:</b> A comprehensive literature search was conducted across major databases to identify cohort studies assessing cardiovascular outcomes in women with a history of PPH. Data from over 9.7 million participants were pooled using a random-effects model to account for inter-study heterogeneity. The primary outcomes included cardiovascular diseases and thromboembolism events. Subgroup analyses were conducted separately for cardiovascular and thromboembolism outcomes. Sensitivity analyses were conducted to examine the consistency and robustness of the pooled estimates. <b>Results:</b> Women with a history of PPH had a 1.76-fold increased risk of developing cardiovascular disease and 2.10-fold increased risk of thromboembolism. The risk was particularly elevated among those requiring transfusion. Cardiovascular risk was most frequent during the first year postpartum and persisted for up to 15 years, particularly among those with hypertensive disorders of pregnancy. Heterogeneity was substantial for cardiovascular disease outcome (<i>I</i><sup>²</sup>=99%) and moderate for thromboembolic outcomes (<i>I</i><sup>²</sup>=43%). Sensitivity analyses reduced heterogeneity for cardiovascular disease to 77.1%. <b>Conclusions:</b> PPH is associated with a significantly increased long-term risk of both cardiovascular and thromboembolism disease. These findings highlight the importance of postpartum cardiovascular risk screening and preventive interventions in women with a history of severe PPH. Future research should adopt standardized methodologies and focus on high-burden settings, particularly in low- and middle-income countries.
DOI: 10.13130/rd_unimi/ui9ecn/0tuna9
title: Giugno_1880_Pagina_017.jpg

description: Bulletin of 1880/06/05