DOI: 10.7270/q2vd6zjj
title: BindingDB Entry 50030996: 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.

description: Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, Aurora kinase B/Inner centromere protein, CaM kinase IV, Casein kinase I isoform delta, Cyclin-Dependent Kinase 5 (CDK5), Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Death-associated protein kinase 3, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Ephrin receptor, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 3, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, High affinity immunoglobulin gamma Fc receptor I, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor-related protein, Interleukin-1 receptor-associated kinase 4, JAK2/TYK2, JAK3/JAK1, LIM domain kinase 1, MAP kinase ERK2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 3, Macrophage colony stimulating factor receptor, Mitogen-activated protein kinase 13 (MAPK13), Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 8, Neurotrophic tyrosine kinase receptor, Neurotrophic tyrosine kinase receptor type 2, PAK1, Protein kinase C delta type, Protein kinase C, eta, Protein kinase C, gamma, Receptor tyrosine-protein kinase erbB-4 (HER4), Rho-associated protein kinase, Ribosomal protein S6 kinase (P70S6K), Ribosomal protein S6 kinase alpha 3, SRC, Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase CHK2, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase D2 (PKD2), Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase PLK3, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase c-TAK1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Blk, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, and p38 delta/gamma, Uniprot L7RSL3, O00141, O00444, O14757, O14965, O15111, O15264, O15530, O43293, O60674, O75116, O96013, O96017, P00519, P00533, P04626, P04629, P05129, P06239, P06241, P06493, P07333, P07948, P08581, P10721, P11309, P11362, P12314, P12931, P14616, P17948, P22607, P23443, P24723, P24941, P27448, P28482, P29317, P29597, P31749, P31751, P35916, P35968, P36888, P41279, P43405, P45984, P48730, P49137, P49840, P49841, P51451, P51812, P51955, P52333, P53350, P53667, P53778, Q00535, Q05655, Q08881, Q13153, Q13188, Q13464, Q13627, Q15078, Q15303, Q16566, Q16620, Q16644, Q96GD4, Q9BZL6, Q9H4B4, Q9NWZ3, Q9P1W9, and Q9Y243