cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25638977
title: Developmental stage and infection status may affect drug distribution in the prostate of rats

description: Prostate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorised into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted.The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC<sub>0-t</sub>prostate/AUC<sub>0-t</sub>plasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC<sub>0-∞</sub>prostate/AUC<sub>0-∞</sub>plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B.The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability. Prostate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear. Rats were categorised into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted. The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC<sub>0-t</sub>prostate/AUC<sub>0-t</sub>plasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC<sub>0-∞</sub>prostate/AUC<sub>0-∞</sub>plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B. The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability.
DOI: 10.6084/m9.figshare.25638977.v2
title: Developmental stage and infection status may affect drug distribution in the prostate of rats

description: Prostate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorised into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted.The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC<sub>0-t</sub>prostate/AUC<sub>0-t</sub>plasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC<sub>0-∞</sub>prostate/AUC<sub>0-∞</sub>plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B.The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability. Prostate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear. Rats were categorised into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted. The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC<sub>0-t</sub>prostate/AUC<sub>0-t</sub>plasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC<sub>0-∞</sub>prostate/AUC<sub>0-∞</sub>plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B. The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability.
DOI: 10.60712/si-id14580.1
title: StrainInfo SI-ID 14580.1

description: StrainInfo dataset 14580 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.6084/m9.figshare.25638977.v1
title: Developmental stage and infection status may affect drug distribution in the prostate of rats

description: Prostate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorized into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted.The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC<sub>0-t</sub>prostate/AUC<sub>0-t</sub>plasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC<sub>0-∞</sub>prostate/AUC<sub>0-∞</sub>plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B.The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability. Prostate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear. Rats were categorized into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted. The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC<sub>0-t</sub>prostate/AUC<sub>0-t</sub>plasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC<sub>0-∞</sub>prostate/AUC<sub>0-∞</sub>plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B. The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability.
DOI: 10.60712/si-id14682.1
title: StrainInfo SI-ID 14682.1

description: StrainInfo dataset 14682 about a strain of Enterococcus hirae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14683.1
title: StrainInfo SI-ID 14683.1

description: StrainInfo dataset 14683 about a strain of Enterococcus hirae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14684.1
title: StrainInfo SI-ID 14684.1

description: StrainInfo dataset 14684 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14481.1
title: StrainInfo SI-ID 14481.1

description: StrainInfo dataset 14481 about a strain of Rhizobium. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.20372/aau_rdm/eq4h0l
title: The Prevalence and Pattern of Major Limb Amputation and Its Associated Factors Among Patients Admitted to Pediatric and Adult Orthopedic Wards at three Public Hospitals in Addis Ababa, Ethiopia.

description: The Data was The Prevalence and Pattern of Major Limb Amputation and Its Associated Factors Among Patients Admitted to Pediatric and Adult Orthopedic Wards at Three Public Hospitals in Addis Ababa, Ethiopia.
DOI: 10.60712/si-id14482.1
title: StrainInfo SI-ID 14482.1

description: StrainInfo dataset 14482 about a strain of Mesorhizobium huakuii. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14483.1
title: StrainInfo SI-ID 14483.1

description: StrainInfo dataset 14483 about a strain of Lactobacillus amylolyticus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.6084/m9.figshare.25869197
title: The late middle Eocene palynoflora of Hareø, West Greenland: polar forests in a vanishing greenhouse world

description: Middle Eocene interbasaltic deposits of Hareø, West Greenland, have yielded a rich leaf and fruit record, which was described in the second half of the nineteenth century. In this study, we describe dispersed spores and pollen from the Aumarûtigssâ Member of the Hareøen Formation in order to obtain a more comprehensive picture of the late middle Eocene vegetation of West Greenland. The spore/pollen assemblage, derived from a resinite-rich coal bed, comprises 123 taxa, of which 14 belong to mosses, ferns and fern-allies, 14 to gymnosperms, and 95 to angiosperms. The most diverse groups of angiosperms are Fagales, comprising 27 taxa, and Rosales, represented by nine taxa. Along with conifers belonging to Pinaceae, these groups reflect the temperate character of the Hareø flora. In addition, a few ‘exotic’ elements include cycads probably belonging to an extinct temperate lineage that was widespread across the Northern Hemisphere during the Paleogene, palm trees, members of Mastixioideae and Santalaceae, both of which were characteristic elements of more southern warm temperate floras of Europe. A detailed comparison with macrofossil and spore/pollen assemblages of roughly coeval sites from Axel Heiberg Island (Canada), Spitsbergen (Arctic Ocean), and ODP site 151-913B in the Norwegian-Greenland Sea, show a highly consistent picture of the vegetation during this time.
DOI: 10.6084/m9.figshare.25869197.v1
title: The late middle Eocene palynoflora of Hareø, West Greenland: polar forests in a vanishing greenhouse world

description: Middle Eocene interbasaltic deposits of Hareø, West Greenland, have yielded a rich leaf and fruit record, which was described in the second half of the nineteenth century. In this study, we describe dispersed spores and pollen from the Aumarûtigssâ Member of the Hareøen Formation in order to obtain a more comprehensive picture of the late middle Eocene vegetation of West Greenland. The spore/pollen assemblage, derived from a resinite-rich coal bed, comprises 123 taxa, of which 14 belong to mosses, ferns and fern-allies, 14 to gymnosperms, and 95 to angiosperms. The most diverse groups of angiosperms are Fagales, comprising 27 taxa, and Rosales, represented by nine taxa. Along with conifers belonging to Pinaceae, these groups reflect the temperate character of the Hareø flora. In addition, a few ‘exotic’ elements include cycads probably belonging to an extinct temperate lineage that was widespread across the Northern Hemisphere during the Paleogene, palm trees, members of Mastixioideae and Santalaceae, both of which were characteristic elements of more southern warm temperate floras of Europe. A detailed comparison with macrofossil and spore/pollen assemblages of roughly coeval sites from Axel Heiberg Island (Canada), Spitsbergen (Arctic Ocean), and ODP site 151-913B in the Norwegian-Greenland Sea, show a highly consistent picture of the vegetation during this time.
DOI: 10.6084/m9.figshare.25981687
title: 71. Mshary mire (source of the Dnieper River, western Russia)

description: 71. Mshary mire (source of the Dnieper River, western Russia)
DOI: 10.6084/m9.figshare.25981687.v1
title: 71. Mshary mire (source of the Dnieper River, western Russia)

description: 71. Mshary mire (source of the Dnieper River, western Russia)
DOI: 10.60712/si-id14484.1
title: StrainInfo SI-ID 14484.1

description: StrainInfo dataset 14484 about a strain of Lactobacillus iners. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14581.1
title: StrainInfo SI-ID 14581.1

description: StrainInfo dataset 14581 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14582.1
title: StrainInfo SI-ID 14582.1

description: StrainInfo dataset 14582 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14583.1
title: StrainInfo SI-ID 14583.1

description: StrainInfo dataset 14583 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14584.1
title: StrainInfo SI-ID 14584.1

description: StrainInfo dataset 14584 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14685.1
title: StrainInfo SI-ID 14685.1

description: StrainInfo dataset 14685 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14686.1
title: StrainInfo SI-ID 14686.1

description: StrainInfo dataset 14686 about a strain of Enterococcus faecium. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14687.1
title: StrainInfo SI-ID 14687.1

description: StrainInfo dataset 14687 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14485.1
title: StrainInfo SI-ID 14485.1

description: StrainInfo dataset 14485 about a strain of Salmonella enterica subsp. enterica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14688.1
title: StrainInfo SI-ID 14688.1

description: StrainInfo dataset 14688 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14486.1
title: StrainInfo SI-ID 14486.1

description: StrainInfo dataset 14486 about a strain of Salmonella enterica subsp. enterica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14487.1
title: StrainInfo SI-ID 14487.1

description: StrainInfo dataset 14487 about a strain of Salmonella enterica subsp. enterica. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14488.1
title: StrainInfo SI-ID 14488.1

description: StrainInfo dataset 14488 about a strain of Pseudomonas. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14585.1
title: StrainInfo SI-ID 14585.1

description: StrainInfo dataset 14585 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14586.1
title: StrainInfo SI-ID 14586.1

description: StrainInfo dataset 14586 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14588.1
title: StrainInfo SI-ID 14588.1

description: StrainInfo dataset 14588 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14689.1
title: StrainInfo SI-ID 14689.1

description: StrainInfo dataset 14689 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14690.1
title: StrainInfo SI-ID 14690.1

description: StrainInfo dataset 14690 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14691.1
title: StrainInfo SI-ID 14691.1

description: StrainInfo dataset 14691 about a strain of Enterococcus gallinarum. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14692.1
title: StrainInfo SI-ID 14692.1

description: StrainInfo dataset 14692 about a strain of Enterococcus faecalis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14489.1
title: StrainInfo SI-ID 14489.1

description: StrainInfo dataset 14489 about a strain of Sphingomonas paucimobilis. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14490.1
title: StrainInfo SI-ID 14490.1

description: StrainInfo dataset 14490 about a strain of Xanthomonas phaseoli pv. dieffenbachiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14491.1
title: StrainInfo SI-ID 14491.1

description: StrainInfo dataset 14491 about a strain of Xanthomonas phaseoli pv. dieffenbachiae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14492.1
title: StrainInfo SI-ID 14492.1

description: StrainInfo dataset 14492 about a strain of Paenibacillus macerans. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14589.1
title: StrainInfo SI-ID 14589.1

description: StrainInfo dataset 14589 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id14590.1
title: StrainInfo SI-ID 14590.1

description: StrainInfo dataset 14590 about a strain of Acetobacter pasteurianus. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.