cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28927195.v1
title: Tobacco and alcohol use are the risk factors responsible for the greatest burden of head and neck cancers: a study from the Global Burden of Disease Study 2019

description: The risk factors associated with cancers of the larynx, nasopharynx, lips, and oral cavity, as well as other pharyngeal cancers, share many similarities. To better understand how these risk factors manifest differently across various head and neck tumor types, we utilized data from the GBD database to conduct an in-depth analysis. Our study employed the 2019 GBD dataset to scrutinize trends in incidence, mortality, and DALYs related to these cancers. This analysis covered the period from 1990 to 2019 and was stratified by sex, age, geographical region, and the socio-demographic index. In 2019, lip and oral cavity cancers were found to have the highest incidence rates, with notably higher ASIRs observed in males compared to females. Interestingly, the ASIRs for laryngeal cancer showed a decreasing trend over the studied time frame from 1990 to 2019. Our findings revealed that smoking posed a significantly greater risk for laryngeal and lip and oral cavity cancers, whereas alcohol consumption was more strongly linked to NPC. Central Europe exhibited the ASDR for laryngeal cancer. For lip and oral cavity cancer, the impact of tobacco chewing on female ASDR was most pronounced in South Asia. In contrast, nasopharyngeal cancer had its highest ASDR in Asia. Our investigation underscores that smoking and alcohol consumption are leading risk factors for cancers of the head and neck, although their effects vary depending on the specific type of cancer, the sex of the patient, age group, and regional demographics. While occupational exposure to carcinogenic substances does not appear to be a predominant factor, it remains an important consideration that should not be overlooked in the comprehensive assessment of risk for these malignancies.
DOI: 10.6084/m9.figshare.29378176
title: Risk of cancer in patients with thalassemia and sickle cell disease: a systematic review

description: Individuals with thalassemia or sickle cell disease (SCD) are at an elevated risk of developing cancer, yet the full extent of this risk remains inadequately characterised. We conducted a systematic review using three databases (MEDLINE, EMBASE and Scopus) to compare the cancer risk in patients with thalassemia and SCD with that of the general population. Secondly, we assessed the impact of other putative risk factors in patients with thalassemia and SCD on cancer risk. Five studies from four countries were included, encompassing a total of 24,439 individuals overall. The risk estimates of developing cancer were highly variable, being affected by study design, population and comparators recruited, and type of cancer. The results showed an elevated cancer risk in SCD and thalassemia patient groups, with the highest incidence observed for hematologic malignancies (especially myeloid leukaemia in SCD patients). Patients with transfusion-dependent thalassemia had a significantly higher overall cancer risk, particularly hepatocellular carcinoma, compared to both non-transfusion-dependent patients and the general population. Other key factors seem to contribute to the increased cancer risk besides transfusion dependency, viral infections, and use of iron chelators. However, people with hemoglobinopathies appeared to be at lower risk of breast and prostate cancer compared to the general population. The findings are limited by variability among studies, including differences in control groups, inconsistent reporting of outcomes, and missing assessments of confounding factors. Therefore, future research with robust methods is essential to improve cancer surveillance and develop targeted prevention strategies for high-risk populations.
DOI: 10.6084/m9.figshare.29378176.v1
title: Risk of cancer in patients with thalassemia and sickle cell disease: a systematic review

description: Individuals with thalassemia or sickle cell disease (SCD) are at an elevated risk of developing cancer, yet the full extent of this risk remains inadequately characterised. We conducted a systematic review using three databases (MEDLINE, EMBASE and Scopus) to compare the cancer risk in patients with thalassemia and SCD with that of the general population. Secondly, we assessed the impact of other putative risk factors in patients with thalassemia and SCD on cancer risk. Five studies from four countries were included, encompassing a total of 24,439 individuals overall. The risk estimates of developing cancer were highly variable, being affected by study design, population and comparators recruited, and type of cancer. The results showed an elevated cancer risk in SCD and thalassemia patient groups, with the highest incidence observed for hematologic malignancies (especially myeloid leukaemia in SCD patients). Patients with transfusion-dependent thalassemia had a significantly higher overall cancer risk, particularly hepatocellular carcinoma, compared to both non-transfusion-dependent patients and the general population. Other key factors seem to contribute to the increased cancer risk besides transfusion dependency, viral infections, and use of iron chelators. However, people with hemoglobinopathies appeared to be at lower risk of breast and prostate cancer compared to the general population. The findings are limited by variability among studies, including differences in control groups, inconsistent reporting of outcomes, and missing assessments of confounding factors. Therefore, future research with robust methods is essential to improve cancer surveillance and develop targeted prevention strategies for high-risk populations.
DOI: 10.15468/dl.9s7m76
title: Occurrence Download

description: A dataset containing 1589 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is COL.2_2",
 "OccurrenceStatus is Present",
 "TaxonKey is Cuniculus paca"
 ]
}

 The dataset includes 1589 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003098-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28280741
title: Right versus left thoracic approach esophagectomy for patients with neoadjuvant immunochemotherapy

description: The purpose of this study was to investigate the safety and efficacy of left thoracic approach (LTA) and right thoracic approach (RTA) in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant immunochemotherapy (NICT). This study included 83 ESCC patients who underwent right transthoracic esophagectomy (<i>n</i> = 61) and left transthoracic esophagectomy (<i>n</i> = 22) after NICT in our hospital from October 2019 to September 2023. The data of these patients were retrospectively analyzed. Compared with the LTA group, the RTA group had a longer operation time (245.6 ± 27.8 min vs. 356.5 ± 83.2 min, <i>p</i> &lt; 0.001) and more lymph nodes were removed (21.0 ± 7.9 vs. 29.3 ± 10.8, <i>p</i> = 0.001). The 3-year disease free survival (DFS) of the LTA group and the RTA group were 61.0% and 65.7% (<i>p</i> = 0.861), and the 3-year overall survival (OS) were 60.7% and 77.4% (<i>p</i> = 0.753) respectively. There was no significant difference in prognosis between the two groups. Lymphovascular invasion was an independent risk factor for DFS (HR = 4.042, <i>p</i> = 0.004) and OS (HR = 4.607, <i>p</i> = 0.003) in patients with ESCC undergoing NICT combined with surgery. There was no difference in postoperative complications and short-term survival in patients with ESCC underwent surgery after NICT regardless of left or right thoracic approach. It is worth noting that lymphovascular invasion has an important impact on the prognosis of these patients.
DOI: 10.6084/m9.figshare.28280741.v1
title: Right versus left thoracic approach esophagectomy for patients with neoadjuvant immunochemotherapy

description: The purpose of this study was to investigate the safety and efficacy of left thoracic approach (LTA) and right thoracic approach (RTA) in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant immunochemotherapy (NICT). This study included 83 ESCC patients who underwent right transthoracic esophagectomy (<i>n</i> = 61) and left transthoracic esophagectomy (<i>n</i> = 22) after NICT in our hospital from October 2019 to September 2023. The data of these patients were retrospectively analyzed. Compared with the LTA group, the RTA group had a longer operation time (245.6 ± 27.8 min vs. 356.5 ± 83.2 min, <i>p</i> &lt; 0.001) and more lymph nodes were removed (21.0 ± 7.9 vs. 29.3 ± 10.8, <i>p</i> = 0.001). The 3-year disease free survival (DFS) of the LTA group and the RTA group were 61.0% and 65.7% (<i>p</i> = 0.861), and the 3-year overall survival (OS) were 60.7% and 77.4% (<i>p</i> = 0.753) respectively. There was no significant difference in prognosis between the two groups. Lymphovascular invasion was an independent risk factor for DFS (HR = 4.042, <i>p</i> = 0.004) and OS (HR = 4.607, <i>p</i> = 0.003) in patients with ESCC undergoing NICT combined with surgery. There was no difference in postoperative complications and short-term survival in patients with ESCC underwent surgery after NICT regardless of left or right thoracic approach. It is worth noting that lymphovascular invasion has an important impact on the prognosis of these patients.
DOI: 10.6084/m9.figshare.28524537
title: Excessive bile acids level predisposes to adverse perinatal outcomes in women with abnormal pre-pregnancy body mass index

description: Both low/high pre-pregnancy body mass index (BMI) and increased bile acid levels during pregnancy (known as gestational hypercholanemia) were risk factors for adverse pregnancy outcomes, with limited information on their joint effects. A total of 63,066 pregnant women were involved in a large retrospective cohort study from May 2014 to December 2018 in Shanghai, China. Data of pregnancy outcomes including hypercholanemia, hypertensive disorders in pregnancy (HDP), preterm delivery, and small for gestation age (SGA), were obtained for multivariable logistic analysis. Pre-pregnancy BMI was negatively associated with serum total bile acid (TBA) concentrations during gestation and the risk of hypercholanemia (<i>p</i> &lt; 0.001). Low pre-pregnancy BMI and hypercholanemia coexisting were related to a 2.71-fold risk (95% confidence intervals [CI], 2.10-3.50) of SGA. Whereas, overweight/obese (OWO) with hypercholanemia are associated with 5.34-fold risk (95% CI 3.93-7.25) of HDP when compared with normal weight women without hypercholanemia. Women with excessive gestational weight gain (GWG) and hypercholanemia had a higher risk of HDP (odds ratio [OR] 3.56, 95% CI 2.91-4.36), and macrosomia (OR 2.95, 95% CI 2.42-3.60), compared with non-hypercholanemia women with adequate GWG. Whereas, women with inadequate GWG and hypercholanemia had increased risks of preterm delivery (OR 1.87, 95% CI 1.44-2.43), and SGA (OR 2.32, 95% CI 1.82-2.96). Low maternal BMI before pregnancy was an independent risk factor for hypercholanemia. Additionally, pre-pregnancy underweight or OWO may amplify the effect of hypercholanemia on adverse pregnancy outcomes. Thus, pre-pregnancy BMI should be considered in the management of adverse perinatal outcomes related to gestational hypercholanemia. Low maternal BMI before pregnancy was a risk factor for gestational hypercholanemia. Pre-pregnancy overweight mothers with hypercholanemia had a higher risk of hypertensive disorders of pregnancy, while underweight mothers with hypercholanemia had a higher risk of delivering small for gestational age infants. These findings emphasize the importance of considering pre-pregnancy BMI as a stratification factor in the management of adverse maternal and neonatal outcomes related to hypercholanemia.
DOI: 10.6084/m9.figshare.28524537.v1
title: Excessive bile acids level predisposes to adverse perinatal outcomes in women with abnormal pre-pregnancy body mass index

description: Both low/high pre-pregnancy body mass index (BMI) and increased bile acid levels during pregnancy (known as gestational hypercholanemia) were risk factors for adverse pregnancy outcomes, with limited information on their joint effects. A total of 63,066 pregnant women were involved in a large retrospective cohort study from May 2014 to December 2018 in Shanghai, China. Data of pregnancy outcomes including hypercholanemia, hypertensive disorders in pregnancy (HDP), preterm delivery, and small for gestation age (SGA), were obtained for multivariable logistic analysis. Pre-pregnancy BMI was negatively associated with serum total bile acid (TBA) concentrations during gestation and the risk of hypercholanemia (<i>p</i> &lt; 0.001). Low pre-pregnancy BMI and hypercholanemia coexisting were related to a 2.71-fold risk (95% confidence intervals [CI], 2.10-3.50) of SGA. Whereas, overweight/obese (OWO) with hypercholanemia are associated with 5.34-fold risk (95% CI 3.93-7.25) of HDP when compared with normal weight women without hypercholanemia. Women with excessive gestational weight gain (GWG) and hypercholanemia had a higher risk of HDP (odds ratio [OR] 3.56, 95% CI 2.91-4.36), and macrosomia (OR 2.95, 95% CI 2.42-3.60), compared with non-hypercholanemia women with adequate GWG. Whereas, women with inadequate GWG and hypercholanemia had increased risks of preterm delivery (OR 1.87, 95% CI 1.44-2.43), and SGA (OR 2.32, 95% CI 1.82-2.96). Low maternal BMI before pregnancy was an independent risk factor for hypercholanemia. Additionally, pre-pregnancy underweight or OWO may amplify the effect of hypercholanemia on adverse pregnancy outcomes. Thus, pre-pregnancy BMI should be considered in the management of adverse perinatal outcomes related to gestational hypercholanemia. Low maternal BMI before pregnancy was a risk factor for gestational hypercholanemia. Pre-pregnancy overweight mothers with hypercholanemia had a higher risk of hypertensive disorders of pregnancy, while underweight mothers with hypercholanemia had a higher risk of delivering small for gestational age infants. These findings emphasize the importance of considering pre-pregnancy BMI as a stratification factor in the management of adverse maternal and neonatal outcomes related to hypercholanemia.
DOI: 10.6084/m9.figshare.29364531
title: Development and validation of a novel prediction model for new-onset atrial fibrillation after lung resection

description: Postoperative atrial fibrillation (POAF) is the most prevalent and potentially life-threatening arrhythmia following thoracic surgery. This study aimed to construct and validate a predictive model for assessing POAF risk. A meta-analysis was conducted to rank risk factors associated with POAF based on their respective risk ratios (RRs). Significant risk factors identified from the meta-analyses were incorporated into the model and assigned weights. External validation was performed using a retrospective cohort from China. Receiver operating characteristic (ROC) curves, calibration plots and decision curve analysis (DCA) were employed to assess the model’s predictive performance, calibration and clinical utility. We screened 40 cohort studies involving 58,899 patients. We developed a risk model that incorporated age ≥ 70 years (RR 2.10, 95% CI 1.34–3.30; <i>p</i> &lt; 0.05), male sex (RR 1.46, 95% CI 1.34–1.60; <i>p</i> &lt; 0.05), COPD (RR 2.28, 95% CI 1.81–2.89; <i>p</i> &lt; 0.05), CAD (RR 1.72, 95% CI 1.49–1.99; <i>p</i> &lt; 0.05), heart failure (RR 1.62, 95% CI 1.12–2.35; <i>p</i> &lt; 0.05), pneumonectomy (RR 2.32, 95% CI 2.01–2.67; <i>p</i> &lt; 0.05) and lobectomy (RR 1.86, 95% CI 1.38–2.51; <i>p</i> &lt; 0.05) and thoracotomy (RR 1.46, 95% CI 1.30–1.64; <i>p</i> &lt; 0.05). Validation was performed in an external cohort of 1546 participants, demonstrating strong discrimination with an area under the receiver operating characteristic curve (95% CI) of 0.89 (95% CI 0.81–0.83). The calibration curve and DCA curve results demonstrated good concordance and applicability. This model, built with easily accessible clinical variables, could accurately predict the risk of POAF. This holds promise for improving clinical decision making and guiding early interventions. In a derivation cohort, a meta-analysis screened 40 cohort studies involving 58,899 patients and developed a risk model, incorporated age ≥ 70 years, male sex, COPD, CAD, heart failure, pneumonectomy, lobectomy, and thoracotomy. The validation cohort from a single centre in China exhibited strong discrimination, achieving an area under the receiver operating characteristic curve of 0.89. High-risk patients could be easily distinguished using calculated risk scores derived from the predictive model, allowing for dynamic assessment of POAF risk.
DOI: 10.6084/m9.figshare.29364531.v1
title: Development and validation of a novel prediction model for new-onset atrial fibrillation after lung resection

description: Postoperative atrial fibrillation (POAF) is the most prevalent and potentially life-threatening arrhythmia following thoracic surgery. This study aimed to construct and validate a predictive model for assessing POAF risk. A meta-analysis was conducted to rank risk factors associated with POAF based on their respective risk ratios (RRs). Significant risk factors identified from the meta-analyses were incorporated into the model and assigned weights. External validation was performed using a retrospective cohort from China. Receiver operating characteristic (ROC) curves, calibration plots and decision curve analysis (DCA) were employed to assess the model’s predictive performance, calibration and clinical utility. We screened 40 cohort studies involving 58,899 patients. We developed a risk model that incorporated age ≥ 70 years (RR 2.10, 95% CI 1.34–3.30; <i>p</i> &lt; 0.05), male sex (RR 1.46, 95% CI 1.34–1.60; <i>p</i> &lt; 0.05), COPD (RR 2.28, 95% CI 1.81–2.89; <i>p</i> &lt; 0.05), CAD (RR 1.72, 95% CI 1.49–1.99; <i>p</i> &lt; 0.05), heart failure (RR 1.62, 95% CI 1.12–2.35; <i>p</i> &lt; 0.05), pneumonectomy (RR 2.32, 95% CI 2.01–2.67; <i>p</i> &lt; 0.05) and lobectomy (RR 1.86, 95% CI 1.38–2.51; <i>p</i> &lt; 0.05) and thoracotomy (RR 1.46, 95% CI 1.30–1.64; <i>p</i> &lt; 0.05). Validation was performed in an external cohort of 1546 participants, demonstrating strong discrimination with an area under the receiver operating characteristic curve (95% CI) of 0.89 (95% CI 0.81–0.83). The calibration curve and DCA curve results demonstrated good concordance and applicability. This model, built with easily accessible clinical variables, could accurately predict the risk of POAF. This holds promise for improving clinical decision making and guiding early interventions. In a derivation cohort, a meta-analysis screened 40 cohort studies involving 58,899 patients and developed a risk model, incorporated age ≥ 70 years, male sex, COPD, CAD, heart failure, pneumonectomy, lobectomy, and thoracotomy. The validation cohort from a single centre in China exhibited strong discrimination, achieving an area under the receiver operating characteristic curve of 0.89. High-risk patients could be easily distinguished using calculated risk scores derived from the predictive model, allowing for dynamic assessment of POAF risk.
DOI: 10.6084/m9.figshare.28137749
title: Health system responsiveness: comparison of different levels of medical institutions in Kunshan City, China

description: Evaluation of health system responsiveness (HSR) can improve patient satisfaction, promote health equity and enhance the quality of health services. To explore the differences in HSR among medical institutions at different levels and in various domains. A multi-stage stratified sampling method was used to select 820 participants aged 18 years and older from Kunshan City, China. Analysis of variance was used for univariate analysis. Linear regression and ordinal logistics were applied to explore the relationship between different hospital levels and HSR. Forest plots were used to illustrate the relationship between each domain and the hospital level. The relationship between hospital level and HSR remained significant (<i>p</i> &lt; 0.05). Compared with primary healthcare institutions, secondary hospitals had lower HSR scores (β = -1.47, 95%CI = [-2.15, −0.79], <i>p</i> &lt; 0.001). Similarly, tertiary hospitals had lower HSR scores compared with primary healthcare institutions (β = -1.54, 95%CI = [-2.39, −0.70], <i>p</i> &lt; 0.001). The study found that attention, communication, basic amenities, social support, and the choice of healthcare providers were lower in secondary hospitals compared to primary healthcare institutions (OR &lt; 1; <i>p</i> &lt; 0.05). In tertiary hospitals, attention, communication, autonomy, basic amenities, social support, and the choice of healthcare provider were lower compared to primary healthcare institutions (OR &lt; 1; <i>p</i> &lt; 0.05). By comparing the HSR of hospitals at different levels, the study identified areas for improvement. Particularly, urgent improvements are needed in prompt attention, communication, basic amenities, social support and the choice of healthcare providers.
DOI: 10.6084/m9.figshare.28137749.v1
title: Health system responsiveness: comparison of different levels of medical institutions in Kunshan City, China

description: Evaluation of health system responsiveness (HSR) can improve patient satisfaction, promote health equity and enhance the quality of health services. To explore the differences in HSR among medical institutions at different levels and in various domains. A multi-stage stratified sampling method was used to select 820 participants aged 18 years and older from Kunshan City, China. Analysis of variance was used for univariate analysis. Linear regression and ordinal logistics were applied to explore the relationship between different hospital levels and HSR. Forest plots were used to illustrate the relationship between each domain and the hospital level. The relationship between hospital level and HSR remained significant (<i>p</i> &lt; 0.05). Compared with primary healthcare institutions, secondary hospitals had lower HSR scores (β = -1.47, 95%CI = [-2.15, −0.79], <i>p</i> &lt; 0.001). Similarly, tertiary hospitals had lower HSR scores compared with primary healthcare institutions (β = -1.54, 95%CI = [-2.39, −0.70], <i>p</i> &lt; 0.001). The study found that attention, communication, basic amenities, social support, and the choice of healthcare providers were lower in secondary hospitals compared to primary healthcare institutions (OR &lt; 1; <i>p</i> &lt; 0.05). In tertiary hospitals, attention, communication, autonomy, basic amenities, social support, and the choice of healthcare provider were lower compared to primary healthcare institutions (OR &lt; 1; <i>p</i> &lt; 0.05). By comparing the HSR of hospitals at different levels, the study identified areas for improvement. Particularly, urgent improvements are needed in prompt attention, communication, basic amenities, social support and the choice of healthcare providers.