cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17026/dans-zea-fs7p
title: Sex differences and loss of Tie2

description: &lt;p&gt;Abstract&lt;br&gt;The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation.&lt;/p&gt;&lt;p&gt;Adult male and female heterozygous Tie2 knockout mice (Tie2+/−) and wild-type controls (Tie2+/+) were included (n=9 per group). Renal and pulmonary injury were determined by wet/dry weight ratio and H&E staining of tissue sections. Protein levels were studied in plasma by ELISA and pulmonary and renal mRNA expression levels by RT-qPCR.&lt;/p&gt;&lt;p&gt;In Tie2+/+ mice, females had higher circulating angiopoietin-2 (138%, p&lt;0.05) compared to males. Gene expression of angiopoietin-1 (204%, p&lt;0.01), angiopoietin-2 (542%, p&lt;0.001) were higher in females compared to males in kidneys, but not in lungs. Gene expression of Tie2, Tie1 and VE-PTP were similar between males and females in kidneys and lungs. Renal and pulmonary wet/dry weight ratio did not differ between Tie2+/+ females and males. Tie2+/+ females had lower circulating NGAL (41%, p&lt;0.01) compared to males, whereas renal NGAL and KIM1 gene expression was unaffected.&lt;br&gt;Interestingly, male Tie2+/- mice had 28% higher renal wet/dry weight ratio (p&lt;0.05) compared to Tie2+/+ males, which was not observed in females nor in lungs. Partial deletion of Tie2 did not affect circulating angiopoietin-1 or angiopoietin-2, but soluble Tie2 was 44% and 53% lower in males and females, respectively, compared to Tie2+/+ mice of the same sex. Renal and pulmonary gene expression of angiopoietin-1, angiopoietin-2, estrogen receptors and other endothelial barrier regulators was comparable between Tie2+/- and Tie2+/+ mice in both sexes.&lt;/p&gt;&lt;p&gt;Female sex seems to protect against renal, but not pulmonary edema in heterozygous Tie2 knock-out mice. This could not be explained by sex dimorphism in the endothelial angiopoietin/Tie2 system.&lt;/p&gt;
description: Date Submitted: 2023-08-17
DOI: 10.17026/dans-25a-4xsy
title: Drainage ditches are year-round greenhouse gas hotlines in temperate peat landscapes

description: &lt;p&gt;Our aim was to assess the role of ditches in the greenhouse gas budget of peat landscapes. Therefore, we quantified year-round (May 2017 till May 2018) emissions of ebullitive and diffusive methane and carbon dioxide emissions from 10 drainage ditches and on several occasions we measured nitrous oxide emissions. We found that all ditches acted as greenhouse gas source on an annual basis, where ebullition made up nearly half of the total greenhouse gas emissions from the ditches and we therefore suggest that ebullition should not be omitted in greenhouse gas studies on drainage ditches. We indicated that 12% of Dutch annual methane emissions can be attributed to ditches, which points out that ditch emissions are important on a national scale and in ditch-rich landscapes globally.&lt;/p&gt;&lt;p&gt;In this repository we provide a detailed R-script (‘Data_analysis_ditch_emissions.R’) with these statistical analyses. We also archive our measured data and data used for our calculations:&lt;/p&gt;&lt;p&gt;- ‘Measured_values_dataset_csv.csv’ contains all measurements for the 10 ditches performed on each sampling time.&lt;/p&gt;&lt;p&gt;- ‘Seasonal_variation_emissions_csv.csv’ was used for data-analysis in our R-script and contains ebullitive CH4, diffusive CH4, diffusive CO2 and total greenhouse gas emissions for all 10 ditches.&lt;/p&gt;&lt;p&gt;- ‘Interpolated_emission_data_workbook_csv.csv’ and ‘Interpolated_water_quality_data_workbook_csv.csv’ where greenhouse gas emissions and water quality variables were calculated for each day of the year by interpolating the measured values from ‘Measured_values_dataset_csv.csv’.&lt;/p&gt;&lt;p&gt;- ‘Yearly_average_values_dataset_csv.csv’ contains the average values of the emissions and water quality variables based on interpolation over a year (the two above mentioned workbooks).&lt;/p&gt;&lt;p&gt;- ‘Average_values_pls_csv.csv’ and ‘PLS_dataframe_csv.csv’ were used for data-analysis of our PLS plot in the R-script and contains average values over the year.&lt;/p&gt;&lt;p&gt;- 'Documentation_metadata_csv.csv' provides all metadata from the above mentioned documents.&lt;/p&gt;&lt;p&gt;The following variables were included in these data records: diffusive methane (CH4) emission; ebullitive CH4 emission; diffusive carbon dioxide (CO2) emission; total greenhouse gas (GHG) emission; oxygen concentration (O2) at the surface water, 20cm below surface and near the sediment; pH at the surface water and 20cm below surface; ditch width; water depth; drainage depth; alkalinity; dissolved inorganic carbon; dissolved CH4 and CO2; production of CH4 and CO2; aluminium, calcium, iron, magnesium, manganese, potassium, sodium, phosphorus, sulphur, silicon, zinc, phosphate, nitrate and ammonium concentrations in the surface water and porewater; loss on ignition; monthly averaged precipitation.&lt;/p&gt;
DOI: 10.17026/dans-xvv-sqbc
title: TOPICS-MDS Memorabel 1-4 care receiver

description: &lt;p&gt;The Older Persons and Informal Caregivers Survey - Minimum DataSet (TOPICS-MDS) is a public data repository which contains information on the physical and mental health and well-being of older persons and informal caregivers and their care use across the Netherlands. The database was developed at the start of The National Care for the Elderly Programme (‘Nationaal Programma Ouderenzorg’ - NPO) on behalf of the Organisation of Health Research and Development (ZonMw - The Netherlands), in part to ensure uniform collection of outcome measures, thus promoting comparability between studies.&lt;/p&gt;&lt;p&gt;Since September 2014, TOPICS-MDS data are also collected within the ZonMw funded ‘Memorabel’ programme, that is specifically aimed at improving the quality of life for people with dementia and the care and support provided to them. In Memorabel round 1 through 4, 11 different research projects have collected TOPICS-MDS data, which has resulted in a pooled database with cross-sectional and (partly) longitudinal data of 1,400 older persons with early onset or advanced dementia and about 950 informal caregivers. Out of these numbers, a number of 919 concerns care receiver - caregiver dyads of whom information on both the care receiver and caregiver is available.&lt;/p&gt;&lt;p&gt;More background information on both NPO and Memorabel 1-4 can be found in the overall information on TOPICS-MDS under the tab ‘Data files’ in DANS EASY (doi.org/10.17026/dans-xvh-dbbf).&lt;/p&gt;&lt;p&gt;The 'TOPICS-MDS Memorabel 1-4 care receiver' dataset, as part of the Memorabel 1-4 database, contains no informal caregiver data, only care receiver (older person) data. The dataset includes data on age, gender, country of birth, level of education, marital status and living situation of the care receiver, as well as data on physical and emotional health and well-being, quality of life, daily functioning and use of care, such as GP visits, home care, day care/treatment and admittance in a hospital, home for the aged or nursing home.&lt;/p&gt;&lt;p&gt;Although the TOPICS-MDS survey instrument for the care receiver was updated in 2017, the same initial version of the instrument was used in both NPO and Memorabel 1-4 projects. The TOPICS-MDS care receiver data from NPO and Memorabel 1-4 can therefore be easily merged.&lt;/p&gt;
DOI: 10.17026/dans-xnp-nkq8
title: Modulation of gastro-intestinal permeability induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Sugar permeability test in urine samples. 16 volunteers received treatments in different orders (Placebo, L. rhamnosus, Yogurt) and urine was collected after 2 and 5 hours. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically. Sucrose and Lactulose content in the urine was measured. Sucrose is hydrolyzed in the duodenum, and is therefore a good marker for gastroduodenal permeability, measured in 0-5h urine. Lactulose can permeate through the paracellular route and rhamnose through the transcellular route in the small intestine. The ratio in 0-5h urine is mainly used for general assessment of the SI permeability.&lt;/p&gt;
description: Date Submitted: 2021-10-27
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients
DOI: 10.17026/dans-x37-9fcp
title: Metabolites Serum: Serum metabolites changes induced by 2-wks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Metabolites profiling of blood samples. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically.&lt;/p&gt;
description: Date Submitted: 2021-12-02
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients
DOI: 10.17026/dans-xed-8qkv
title: Ivium Raw data of Charging and Discharging experiment for article "Marine sediment mixed with activated carbon allows electricity production and storage from internal and external energy sources: a new rechargeable bio-battery with bi-directional electron transfer properties"

description: &lt;p&gt;In this study, we investigated the potential of marine sediment and activated carbon to generate and store electricity. Both internal and external energy supply was validated for storage behavior. Four types of anode electrode compositions were investigated. Two were mixture of different volumes of activated carbon (AC) and mixed with Dutch Eastern Scheldt marine sediment (67% AC, 33% AC) and the others were 100% AC or 100% marine sediment based. Each composition was duplicated. Operating these BES’s under MFC mode with solely marine sediment as the anode electron donor resulted in the creation of a bio-battery system. The recharge time of such bio-battery does depend on the fuel content and its usage.&lt;/p&gt;
DOI: 10.17026/dans-xkm-6qks
title: Biomarkers: Blood biomarkers and proteome response by 2-wks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Biomarkers profiling of human blood serum. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically.&lt;/p&gt;
description: Date Submitted: 2021-12-02
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients
DOI: 10.17026/dans-xnr-7rch
title: PBMCs: Systemic immune adaptation and blood transcriptional changes induced by 2-wks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Transcriptomic profiling of human Peripheral Blood Mononuclear Cells (PBMCs). The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically.&lt;/p&gt;
description: Date Submitted: 2021-12-02
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients
DOI: 10.17026/dans-zrm-7r4z
title: Permanent Onderzoek van de Leefsituatie - POLS Gezondheid 1981-2009

description: &lt;p&gt;Doel&lt;br&gt;Een zo volledig mogelijk overzicht geven van ontwikkelingen in de gezondheid, medische consumptie, leefstijl en preventief gedrag van de Nederlandse bevolking.&lt;/p&gt;&lt;p&gt;Doelpopulatie&lt;br&gt;Voor het merendeel van de onderwerpen personen van 0 jaar en ouder in particuliere huishoudens in Nederland. Voor sommige onderwerpen geldt een aparte leeftijdsgrens.&lt;/p&gt;&lt;p&gt;Statistische eenheid&lt;br&gt;Personen.&lt;/p&gt;&lt;p&gt;Aanvang onderzoek&lt;br&gt;Sinds 1 januari 1981 wordt door het CBS een continue Gezondheidsenquête gehouden. Tot en met 1996 betrof dit een opzichzelfstaand onderzoek (POLS MGA Gezondheidsenquête). Met ingang van 1 januari 1997 maakt deze enquête deel uit van het Permanent Onderzoek LeefSituatie - POLS als de module Gezondheid (POLS Gezondheid) . In de periode 1997-2006 heeft een aanvullend vragenblok met betrekking tot het thema 'kwaliteit van de arbeid` deel uit gemaakt van deze module (POLS Gezondheid en Arbeid).&lt;/p&gt;&lt;p&gt;Frequentie&lt;br&gt;Jaarlijks.&lt;/p&gt;&lt;p&gt;Dit betreft een beveiligd microbestand van het Centraal Bureau voor de Statistiek-CBS. Beveiligde micro-bestanden zijn bestanden die zodanig bewerkt zijn dat herkenning van individuen en huishoudens uitgesloten is.&lt;/p&gt;&lt;p&gt;Met ingang van 2010 wordt de Gezondheidsenquête weer als op zichzelf staand onderzoek uitgevoerd.&lt;/p&gt;
description: &lt;p&gt;11-07-2016&lt;br&gt;- De documentatie in deze dataset blijkt niet volledig. De vragenlijst ontbreekt bij data van 1981-1989. Deze wordt naar verwachting in de loop van het jaar toegevoegd.&lt;br&gt;- Daarnaast blijkt bij de variabele var015 (enquêtejaar) in het databestand genaamd 'MGA196' voor 1996 onterecht de waarde 95 ingevuld te zijn, dit moet 96 zijn. Dit wordt in dezelfde periode gecorrigeerd.&lt;/p&gt;
DOI: 10.17026/dans-xgx-zuht
title: HUMAN FUNCTIONAL GENOMICS IN HEALTHY TANZANIA INDIVIDUALS: A SYSTEM BIOLOGY APPROACH IN UNDERSTANDING INDIVIDUAL VARIATIONS IN IMMUNE RESPONSE

description: &lt;p&gt;The dataset contains the results from a cross-sectional study assessing the variations in immune response in healthy adult individuals enrolled in the Kilimanjaro region in Northern Tanzania (300-TZ-FG). A total of 323 healthy volunteers aged 18–70 years were enrolled in this study. Primary outcomes were the immune response, measured by the capacity of the circulating immune cells to produce cytokines following ex-vivo stimulation with different pathogenic stimuli. In addition, the circulating inflammatory cytokines and adipokines, cell counts, and thrombin and plasmin generation were also measured. More details on the study are given in the published article: https://doi.org/10.1038/s41590-021-00867-8&lt;/p&gt;
description: Date Submitted: 2022-04-30
DOI: 10.17026/dans-zym-ad8w
title: TruCulture: Systemic immune adaptation and responsiveness induced by 2-wks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Immunophenotyping of whole blood after ex-vivo stimulus. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically.&lt;/p&gt;
description: Date Submitted: 2021-12-02
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients
DOI: 10.17026/dans-xhw-dhpr
title: 16S: Modulation of small intestinal microbial composition induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Metataxonomic profiling (16S) of ileostomy samples. The samples were collected for the INSIDE double-blinded, placebo controlled explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically. Subjects participated in an approximately 100 days long trial with 3 intervention periods.&lt;br&gt;27 ileal effluent samples were collected per subject allowing a longitudinal analysis of the impact that consumpion of milk fermented products may have on the small intestinal microbial composition.&lt;/p&gt;
description: Date Submitted: 2021-11-19
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients
DOI: 10.17026/dans-xuc-jsux
title: Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) – Metabolomics data set

description: &lt;p&gt;Small-molecule profiling data for 79 children included in the Biomarker Research in ADHD: the Impact of Nutrition (BRAIN) study, an open-label trial during which children with ADHD followed a few-foods diet (FFD). Sampling was done before the FFD (t1) and after 5 weeks of FFD (t2).&lt;/p&gt;
description: Date Submitted: 2020-02-19
DOI: 10.17026/dans-x3n-64rp
title: Biologische teelt op een zuidelijke zandgrond: opbrengst, bemesting, bodemkwaliteit en stikstofverliezen

description: &lt;p&gt;In deze dataset en het bijbehorende rapport worden de resultaten van het biologische bedrijfssysteem op WUR-proeflocatie Vredepeel in de periode 2001-2016 gepresenteerd met focus op gewasopbrengst, bodemkwaliteit, bemesting en stikstofuitspoeling.&lt;br&gt;Het biologisch systeem heeft opbrengsten die gemiddeld 6% onder het streven liggen, een goede bodemvruchtbaarheid en een nitraatconcentratie in het grondwater onder de norm van de nitraatrichtlijn. De nutriëntenoverschotten van stikstof, fosfaat en kali zijn hoger dan de streefwaarde. De opbrengsten liggen gemiddeld ruim onder die van de gangbare teelt door het optreden van ziekten en plagen. Veranderingen in opbrengst, bodemkwaliteit en uitspoeling in de periode 2000-2016 zijn niet met metingen vastgesteld behalve een stijging in organisch stofgehalte. Hierdoor kan ook niet aangetoond worden dat door biologische landbouw de bodemkwaliteit verbetert en ecosysteemdiensten verbeteren. Onduidelijk is hoe het biologisch systeem tot een lage uitspoeling komt bij een relatief hoge stikstof- en organische stofaanvoer. Nader onderzoek is hiervoor nodig.&lt;/p&gt;
DOI: 10.17026/dans-27s-zkxe
title: Effect van organische stofbeheer op opbrengst, bodemkwaliteit en stikstofverliezen op een zuidelijke zandgrond

description: &lt;p&gt;In het bedrijfssysteemonderzoek Bodemkwaliteit op zand op WUR-proeflocatie Vredepeel worden twee gangbare bedrijfssystemen met elkaar vergeleken gedurende de periode 2011-2016: één systeem met een gebruikelijke organische stofaanvoer met gebruik van drijfmest (STANDAARD) en één systeem met een lage organische stofaanvoer met gebruik van meststoffen zonder of met een laag gehalte organische stof (LAAG).&lt;br&gt;Systeem LAAG heeft een 5% lagere totale droge stofproductie (p&lt;0,05) en een lager risico op stikstofuitspoeling. De nitraatconcentraties in het grondwater (n.s.), de N-min voorraden in de bodem in het najaar (p&lt;0,1), en het stikstofoverschot (n.s.) zijn in LAAG in alle gevallen lager dan STANDAARD. In beide systemen ligt de nitraatconcentratie in het grondwater boven de norm in de Europese nitraatrichtlijn (50 mg/l). Het organisch stofgehalte in LAAG is 0,4%-punt lager dan STANDAARD (p&lt;0,01). Andere bodemparameters zijn in de loop van de tijd van de proef niet veranderd. Er kon geen duidelijk verband afgeleid worden tussen de aanvoer van organische stof en lachgasemissies. Aanvoer van extra organische stof in de vorm van compost in zowel LAAG als STANDAARD leidt tot hogere opbrengsten (n.s.), met name in systeem LAAG, maar geen verhoging van de uitspoeling. De opbrengsten in STANDAARD liggen gemiddeld 15% lager dan de praktijkopbrengsten op de proeflocatie, mogelijk veroorzaakt door de strikte bemestingsstrategie sinds de start van het bedrijfssystemenonderzoek in 1988.&lt;br&gt;Met de indicaties voor lagere stikstofverliezen, hoewel nog steeds boven de nitraatnorm, bij een lagere aanvoer van organische stof, maar tegelijkertijd lagere opbrengsten geeft dit onderzoek een dilemma weer tussen een belangrijk milieuaspect en de economie van het boerenbedrijf.&lt;/p&gt;
DOI: 10.17026/dans-zcw-8x6j
title: PERISCOPE
title: Pertussis correlates of protection europe

description: &lt;p&gt;PERISCOPE will develop novel functional antibody and cellular assays and employ cutting edge science to characterize innate and adaptive immune responses. Immune responses will be characterized through clinical trials that will compare aP with wP vaccine in a range of age groups, including infants. The impact of immunization in pregnancy on subsequent immune responses of infants to aP or wP will be determined in a European and an African setting. Experimental human and pre-clinical B. pertussis challenge models will be developed to identify immune signatures that predict protection against B. pertussis colonisation and/or disease. These signatures will then be compared to immune responses following vaccination. Potential biomarkers of protection against colonisation and/or disease will subsequently be evaluated in the human challenge model, cohorts of naturally infected individuals, including exposed household contacts, and in the pre-clinical model. A second pre-clinical model will be used to gain insight into the underlying mechanisms of protection.&lt;/p&gt;
description: Date Submitted: 2021-11-11
DOI: 10.17026/dans-zsf-2w9p
title: Burden of treatment among Delhi's homeless: analysing Street Medicine consultations

description: &lt;p&gt;This dataset contains the raw diagnoses made by Street Medicine teams from Jan '16 to Jun '18. Street Medicine teams in Delhi have been recording demographic and diagnostic information about the homeless patients they treat since January 2016. Each team consists of one doctor, one nurse or auxiliary-nurse-midwife, one social worker and one driver-cum-social worker. Across the period of data collection, the team repeatedly visited 21 locations, which reflects their two-weekly schedule. Two to three locations are usually visited per day, with some locations visited more than once over a two-week period. When a Street Medicine professional treats a homeless individual, a new entry is made in a register of the individual’s indicated condition, symptom or disease, as well as their name, date of consultation, age, sex, religion, location of consultation, and place of origin.&lt;/p&gt;
DOI: 10.17026/dans-z3q-vvz4
title: Modulation of small intestinal small chain fatty acid profile induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

description: &lt;p&gt;Short chain fatty acid profiling of ileostomy samples. 16 volunteers received yogurt, L. rhamnosus or placebo in different orders. Ileostomy samples were collected in the morning after breakfast at the beginning and at the end of the 2 weeks intervention period. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal environment and systematically.&lt;/p&gt;
description: Date Submitted: 2021-11-05
description: INSIDE project: Ileostomy-cohort-study-with-two-probiotics, a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients