cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4312307
title: Supplementary Material for: Calcium-Phosphate-Osteopontin Particles Reduce Biofilm Formation and pH Drops in in situ Grown Dental Biofilms

description: This 2-period crossover study investigated the effect of calcium-phosphate-osteopontin particles on biofilm formation and pH in 48-h biofilms grown in situ. Bovine milk osteopontin is a highly phosphorylated glycoprotein that has been shown to interfere with bacterial adhesion to salivary-coated surfaces. Calcium-phosphate-osteopontin particles have been shown to reduce biofilm formation and pH drops in a 5-species laboratory model of dental biofilm without affecting bacterial viability. Here, smooth surface biofilms from 10 individuals were treated ex vivo 6 times/day for 30 min with either calcium-phosphate-osteopontin particles or sterile saline. After growth, the amount of biofilm formed was determined by confocal microscopy, and pH drops upon exposure to glucose were monitored using confocal-microscopy-based pH ratiometry. A total of 160 biofilms were analysed. No adverse effects of repeated ex vivo treatment with calcium-phosphate-osteopontin particles were observed. Particle treatment resulted in a 32% lower amount of biofilm formed (<i>p</i> &lt; 0.05), but large inter-individual differences could be observed. Biofilm pH was significantly higher upon particle treatment, both shortly after the addition of glucose and after 30 min of incubation with glucose (<i>p</i> &lt; 0.05). Calcium-phosphate-osteopontin particles may represent a new therapeutic approach to caries control and aim at directly targeting virulence factors involved in the caries process. Further studies are required to determine the effect of particle treatment on more acidogenic/aciduric biofilms as well as the remineralizing potential of the particles.
DOI: 10.6084/m9.figshare.4312310
title: Supplementary Material for: Effect of Tannic Acid on the Protective Properties of the in situ Formed Pellicle

description: <b><i>Objectives:</i></b> In the present in situ/ex vivo study the impact of tannic acid on the erosion-protective properties of the enamel pellicle was tested. Additionally, the antiadherent and antibacterial effects of tannic acid were evaluated. <b><i>Methods:</i></b> The pellicle was formed in situ on bovine enamel samples fixed on individual splints worn by 6 subjects. Following 1 min of pellicle formation the volunteers rinsed for 10 min with tannic acid. After further oral exposure for 19 min, 109 min, and 8 h overnight, respectively, slabs were incubated in HCl ex vivo (pH 2.0, 2.3, 3.0) over 120 s. Subsequently, kinetics of calcium and phosphate release were measured photometrically. Samples after a 1-min fluoride mouth rinse as well as enamel samples with and without a 30-min in situ pellicle served as controls. Antiadherent effects were evaluated after a 1-min rinse with tannic acid and oral exposure of the slabs overnight. DAPI (4′,6-diamidino-2-phenylindole) combined with concanavalin A staining and live/dead staining was used for fluorescence microscopic visualization and quantification of adherent bacteria and glucans. Modification of the pellicle's ultrastructure by tannic acid was evaluated by transmission electron microscopy (TEM). <b><i>Results:</i></b> Tannic acid significantly improved the erosion-protective properties of the pellicle in a pH-dependent manner. Bacterial adherence and glucan formation on enamel were significantly reduced after rinses with tannic acid as investigated by fluorescence microscopy. TEM imaging indicated that rinsing with tannic acid yielded a sustainable modification of the pellicle; it was distinctly more electron dense. <b><i>Conclusion:</i></b> Tannic acid offers an effective and sustainable approach for the prevention of caries and erosion.
DOI: 10.6084/m9.figshare.4312307.v1
title: Supplementary Material for: Calcium-Phosphate-Osteopontin Particles Reduce Biofilm Formation and pH Drops in in situ Grown Dental Biofilms

description: This 2-period crossover study investigated the effect of calcium-phosphate-osteopontin particles on biofilm formation and pH in 48-h biofilms grown in situ. Bovine milk osteopontin is a highly phosphorylated glycoprotein that has been shown to interfere with bacterial adhesion to salivary-coated surfaces. Calcium-phosphate-osteopontin particles have been shown to reduce biofilm formation and pH drops in a 5-species laboratory model of dental biofilm without affecting bacterial viability. Here, smooth surface biofilms from 10 individuals were treated ex vivo 6 times/day for 30 min with either calcium-phosphate-osteopontin particles or sterile saline. After growth, the amount of biofilm formed was determined by confocal microscopy, and pH drops upon exposure to glucose were monitored using confocal-microscopy-based pH ratiometry. A total of 160 biofilms were analysed. No adverse effects of repeated ex vivo treatment with calcium-phosphate-osteopontin particles were observed. Particle treatment resulted in a 32% lower amount of biofilm formed (<i>p</i> &lt; 0.05), but large inter-individual differences could be observed. Biofilm pH was significantly higher upon particle treatment, both shortly after the addition of glucose and after 30 min of incubation with glucose (<i>p</i> &lt; 0.05). Calcium-phosphate-osteopontin particles may represent a new therapeutic approach to caries control and aim at directly targeting virulence factors involved in the caries process. Further studies are required to determine the effect of particle treatment on more acidogenic/aciduric biofilms as well as the remineralizing potential of the particles.
DOI: 10.6084/m9.figshare.4312232
title: Supplementary Material for: Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

description: Fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) develop in the mammalian prenatal and postnatal testes, respectively. In mice, FLCs emerge in the interstitial space of the testis as early as embryonic day 12.5 and thereafter increase in number during the fetal stage. We previously established a transgenic mouse line in which FLCs are labeled with EGFP and demonstrated that the EGFP-labeled FLCs were present even in adult testes. However, the characteristics of FLCs during postnatal stages remained unclear. In the present study, a comparison of the transcriptomes of FLCs from prenatal and postnatal testes and of ALCs from adult testes revealed that FLCs gradually alter their characteristics across developmental stages and come to roughly resemble ALCs. Many cholesterogenic genes simultaneously expressed a unique alternation pattern, while many oxidative phosphorylation and β-oxidation (both mitochondrial functions) genes showed a different unique pattern. These metabolic gene expression alterations might be triggered by milieu changes, such as nutrient and oxygen supply, from the prenatal to the postnatal period.
DOI: 10.6084/m9.figshare.4312259
title: Supplementary Material for: Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry

description: <strong><em>Background:</em></strong> Dementia and stroke are major causes of disability in the elderly. However, the association between pre-stroke dementia and functional outcome after stoke remains unresolved. We aimed to determine this association in patients with acute ischemic stroke. <b><i>Methods:</i></b> Among patients registered in the Fukuoka Stroke Registry from June 2007 to May 2015, 4,237 patients with ischemic stroke within 24 h of onset, who were functionally independent before the onset, were enrolled in this study. Pre-stroke dementia was defined as any type of dementia that was present prior to the index stroke. Primary and secondary study outcomes were poor functional outcome (modified Rankin Scale 3-6) at 3 months after the stroke onset and neurological deterioration (≥2-point increases on the National Institutes of Health Stroke Scale score during hospitalization), respectively. For propensity score (PS)-matched cohort study to control confounding variables for pre-stroke dementia, 318 pairs of patients with and without pre-stroke dementia were also selected on the basis of 1:1 matching. Multivariable logistic regression models and conditional logistic regression analysis were used to quantify associations between pre-stroke dementia and study outcomes. <b><i>Results:</i></b> Of all 4,237 participants, 347 (8.2%) had pre-stroke dementia. The frequencies of neurological deterioration and poor functional outcome were significantly higher in patients with pre-stroke dementia than in those without pre-stroke dementia (neurological deterioration, 16.1 vs. 7.1%, <i>p</i> &lt; 0.01; poor functional outcome, 63.7 vs. 27.1%, <i>p</i> &lt; 0.01). Multivariable analysis showed that pre-stroke dementia was significantly associated with neurological deterioration (OR 1.67; 95% CI 1.14-2.41; <i>p</i> &lt; 0.01) and poor functional outcome (OR 2.91; 95% CI 2.17-3.91; <i>p</i> &lt; 0.01). In the PS-matched cohort study, the same trends were observed between the pre-stroke dementia and neurological deterioration (OR 2.60; 95% CI 1.17-5.78; <i>p</i> &lt; 0.01) and between the dementia and poor functional outcome (OR 3.62; 95% CI 1.89-6.95; <i>p</i> &lt; 0.01). <b><i>Conclusions:</i></b> Pre-stroke dementia was significantly associated with higher risks for poor functional outcome at 3 months after stroke onset as well as for neurological deterioration during hospitalization in patients with acute ischemic stroke.
DOI: 10.6084/m9.figshare.4312259.v1
title: Supplementary Material for: Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry

description: <strong><em>Background:</em></strong> Dementia and stroke are major causes of disability in the elderly. However, the association between pre-stroke dementia and functional outcome after stoke remains unresolved. We aimed to determine this association in patients with acute ischemic stroke. <b><i>Methods:</i></b> Among patients registered in the Fukuoka Stroke Registry from June 2007 to May 2015, 4,237 patients with ischemic stroke within 24 h of onset, who were functionally independent before the onset, were enrolled in this study. Pre-stroke dementia was defined as any type of dementia that was present prior to the index stroke. Primary and secondary study outcomes were poor functional outcome (modified Rankin Scale 3-6) at 3 months after the stroke onset and neurological deterioration (≥2-point increases on the National Institutes of Health Stroke Scale score during hospitalization), respectively. For propensity score (PS)-matched cohort study to control confounding variables for pre-stroke dementia, 318 pairs of patients with and without pre-stroke dementia were also selected on the basis of 1:1 matching. Multivariable logistic regression models and conditional logistic regression analysis were used to quantify associations between pre-stroke dementia and study outcomes. <b><i>Results:</i></b> Of all 4,237 participants, 347 (8.2%) had pre-stroke dementia. The frequencies of neurological deterioration and poor functional outcome were significantly higher in patients with pre-stroke dementia than in those without pre-stroke dementia (neurological deterioration, 16.1 vs. 7.1%, <i>p</i> &lt; 0.01; poor functional outcome, 63.7 vs. 27.1%, <i>p</i> &lt; 0.01). Multivariable analysis showed that pre-stroke dementia was significantly associated with neurological deterioration (OR 1.67; 95% CI 1.14-2.41; <i>p</i> &lt; 0.01) and poor functional outcome (OR 2.91; 95% CI 2.17-3.91; <i>p</i> &lt; 0.01). In the PS-matched cohort study, the same trends were observed between the pre-stroke dementia and neurological deterioration (OR 2.60; 95% CI 1.17-5.78; <i>p</i> &lt; 0.01) and between the dementia and poor functional outcome (OR 3.62; 95% CI 1.89-6.95; <i>p</i> &lt; 0.01). <b><i>Conclusions:</i></b> Pre-stroke dementia was significantly associated with higher risks for poor functional outcome at 3 months after stroke onset as well as for neurological deterioration during hospitalization in patients with acute ischemic stroke.
DOI: 10.6084/m9.figshare.4312091
title: Dataset for the paper "On the neural substrates of the disposition effect and return performance"

description: Dataset for the paper "On the neural substrates of the disposition effect and return performance"
DOI: 10.6084/m9.figshare.4312085
title: DB L'Aquila paper

description: Raw data processed in the project
DOI: 10.6084/m9.figshare.4312085.v1
title: DB L'Aquila paper

description: Raw data processed in the project
DOI: 10.6084/m9.figshare.4312073
title: DATI Studenti elaboraz.xlsx

description: Students enrollment trend at the University of L'Aquila
DOI: 10.6084/m9.figshare.4312079
title: keratoplasty

description: Some data on keratoplasty<br>
DOI: 10.6084/m9.figshare.4312073.v1
title: DATI Studenti elaboraz.xlsx

description: Students enrollment trend at the University of L'Aquila
DOI: 10.6084/m9.figshare.4312079.v1
title: keratoplasty

description: Some data on keratoplasty<br>
DOI: 10.6084/m9.figshare.4312064
title: The effects of CPs and GPs teamwork on the quality of their relationships and clinical outcomes

description: Description will be available soon..
DOI: 10.6084/m9.figshare.4312064.v1
title: The effects of CPs and GPs teamwork on the quality of their relationships and clinical outcomes

description: Description will be available soon..
DOI: 10.1285/i24212113v6i2-1p144
title: Troubling history and diversity: Disciplinary decadence in community psychology

description: According to Lewis Gordon, one is said to adhere to disciplinary decadence when disciplinary orthodoxy is prioritised over how particular problems are addressed. Under neoliberal capitalism, disciplinary decadence oftentimes reproduces a politics that is based on individual – rather than collective – freedoms (i.e. a liberal politics). This article interrogates two common disciplinarily decadent ways of politicising community psychology (CP), namely: parochial historicization and respect for diversity as liberal tolerance. We contend that in both cases, pseudo-progressive language is used to advance a liberal politics distorts the collective change-making capacities of CP. In an attempt to break from such liberal politics, we consider the progressive potential of an ethic of discomfort in CP. It is through this ethic, we argue, that we can begin to recognize the institutional limitations of CP, while realizing the role that CP is (and is not) able to play in community struggles. We conclude by calling for a CP that signifies a critical approach rather than a set of disciplinarily-bound dictums.
DOI: 10.6084/m9.figshare.12911543
title: Supplementary Material for: Lipid Loss Increases Stratum Corneum Stress and Drying Rates

description: <b><i>Background:</i></b> The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. <b><i>Objectives:</i></b> This work presents the contributions of the lipid bilayers and NMFs to the barrier properties and mechanical responses of human SC. <b><i>Methods:</i></b> We performed 2 biomechanical experiments, substrate curvature testing and double cantilever beam cohesion measurements, on isolated human SC exposed to either water, a 1:1 mixture of acetone/ether, or a 1:1 mixture of chloroform/methanol for various durations. <b><i>Results:</i></b> We show that treating ex vivo SC with organic solvents results in lipid extraction which increases with duration of exposure. This extraction is tied to a remarkably linear increase in the levels and rates of biaxial stress development during drying/hydration cycles. This effect appears to be tied to the total amounts of lipids extracted. Furthermore, striking changes are seen in the intercellular cohesion properties of the tissue after solvent exposure. Interestingly, changes in drying stress profiles are not observed after treatment with water, which has been previously shown to remove NMFs from the tissue, and which therefore might be expected to induce changes in the drying behavior of the skin. However, changes in intercellular cohesion and the SC cohesion gradient are seen, suggesting impacts on the corneodesmosome protein binding junctions within the tissue. <b><i>Conclusions:</i></b> These results suggest that lipid loss causes marked increases in SC drying stresses, which may in turn contribute to changes in skin perception. NMF extraction may be important in vivo, but has remarkably little impact in isolated SC.
DOI: 10.6084/m9.figshare.12911543.v1
title: Supplementary Material for: Lipid Loss Increases Stratum Corneum Stress and Drying Rates

description: <b><i>Background:</i></b> The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. <b><i>Objectives:</i></b> This work presents the contributions of the lipid bilayers and NMFs to the barrier properties and mechanical responses of human SC. <b><i>Methods:</i></b> We performed 2 biomechanical experiments, substrate curvature testing and double cantilever beam cohesion measurements, on isolated human SC exposed to either water, a 1:1 mixture of acetone/ether, or a 1:1 mixture of chloroform/methanol for various durations. <b><i>Results:</i></b> We show that treating ex vivo SC with organic solvents results in lipid extraction which increases with duration of exposure. This extraction is tied to a remarkably linear increase in the levels and rates of biaxial stress development during drying/hydration cycles. This effect appears to be tied to the total amounts of lipids extracted. Furthermore, striking changes are seen in the intercellular cohesion properties of the tissue after solvent exposure. Interestingly, changes in drying stress profiles are not observed after treatment with water, which has been previously shown to remove NMFs from the tissue, and which therefore might be expected to induce changes in the drying behavior of the skin. However, changes in intercellular cohesion and the SC cohesion gradient are seen, suggesting impacts on the corneodesmosome protein binding junctions within the tissue. <b><i>Conclusions:</i></b> These results suggest that lipid loss causes marked increases in SC drying stresses, which may in turn contribute to changes in skin perception. NMF extraction may be important in vivo, but has remarkably little impact in isolated SC.
DOI: 10.6084/m9.figshare.4312046
title: Iddawela et al: Integrative analysis of copy number and gene expression using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study

description: Copy number data from the paper Iddawela et al: Integrative analysis of copy number and gene expression using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study
DOI: 10.5517/ccdc.csd.cc23cgrq
title: CCDC 1947443: Experimental Crystal Structure Determination

description: Related Article: Jiayong Zhang, Jiahang Hao, Zhiqiang Huang, Jie Han, Zhengjie He|2020|Chem.Commun.|56|10251|doi:10.1039/D0CC04086J
DOI: 10.6084/m9.figshare.4312004.v1
title: Challenges in software testing-Survey questions

description: Challenges in software testing-Survey questions
DOI: 10.5517/ccdc.csd.cc24wf3l
title: CCDC 1992559: Experimental Crystal Structure Determination

description: Related Article: Ghodrat Mahmoudi, Farhad Akbari Afkhami, Alan R. Kennedy, Fedor I. Zubkov, Ennio Zangrando, Alexander M. Kirillov, Elies Molins, Mariusz P. Mitoraj, Damir A. Safin|2020|Dalton Trans.|49|11238|doi:10.1039/D0DT01704C
DOI: 10.5517/ccdc.csd.cc24wf4m
title: CCDC 1992560: Experimental Crystal Structure Determination

description: Related Article: Ghodrat Mahmoudi, Farhad Akbari Afkhami, Alan R. Kennedy, Fedor I. Zubkov, Ennio Zangrando, Alexander M. Kirillov, Elies Molins, Mariusz P. Mitoraj, Damir A. Safin|2020|Dalton Trans.|49|11238|doi:10.1039/D0DT01704C
DOI: 10.5517/ccdc.csd.cc24wf5n
title: CCDC 1992561: Experimental Crystal Structure Determination

description: Related Article: Ghodrat Mahmoudi, Farhad Akbari Afkhami, Alan R. Kennedy, Fedor I. Zubkov, Ennio Zangrando, Alexander M. Kirillov, Elies Molins, Mariusz P. Mitoraj, Damir A. Safin|2020|Dalton Trans.|49|11238|doi:10.1039/D0DT01704C
DOI: 10.5517/ccdc.csd.cc24wf6p
title: CCDC 1992562: Experimental Crystal Structure Determination

description: Related Article: Ghodrat Mahmoudi, Farhad Akbari Afkhami, Alan R. Kennedy, Fedor I. Zubkov, Ennio Zangrando, Alexander M. Kirillov, Elies Molins, Mariusz P. Mitoraj, Damir A. Safin|2020|Dalton Trans.|49|11238|doi:10.1039/D0DT01704C
DOI: 10.5517/ccdc.csd.cc2533w9
title: CCDC 1999000: Experimental Crystal Structure Determination

description: Related Article: Yong Ai,  Yu-Ling Zeng,  Wen-Hui He,  Xue-Qin Huang,  Yuan-Yuan Tang|2020|J.Am.Chem.Soc.|142|13989|doi:10.1021/jacs.0c06936
DOI: 10.5517/ccdc.csd.cc2533xb
title: CCDC 1999001: Experimental Crystal Structure Determination

description: Related Article: Yong Ai,  Yu-Ling Zeng,  Wen-Hui He,  Xue-Qin Huang,  Yuan-Yuan Tang|2020|J.Am.Chem.Soc.|142|13989|doi:10.1021/jacs.0c06936
DOI: 10.5517/ccdc.csd.cc2539k5
title: CCDC 1999176: Experimental Crystal Structure Determination

description: Related Article: Rebecca Scatena, Fabio Montisci, Arianna Lanza, Nicola P. M. Casati, Piero Macchi|2020|Inorg.Chem.|59|10091|doi:10.1021/acs.inorgchem.0c01229
DOI: 10.5517/ccdc.csd.cc2539l6
title: CCDC 1999177: Experimental Crystal Structure Determination

description: Related Article: Rebecca Scatena, Fabio Montisci, Arianna Lanza, Nicola P. M. Casati, Piero Macchi|2020|Inorg.Chem.|59|10091|doi:10.1021/acs.inorgchem.0c01229
DOI: 10.5517/ccdc.csd.cc24srsh
title: CCDC 1990007: Experimental Crystal Structure Determination

description: Related Article: Huifen Hu, Jingjing Pang, Peijun Gong, Lijuan Chen, Junwei Zhao|2020|Inorg.Chem.|59|11287|doi:10.1021/acs.inorgchem.0c00768
DOI: 10.5517/ccdc.csd.cc2539m7
title: CCDC 1999178: Experimental Crystal Structure Determination

description: Related Article: Rebecca Scatena, Fabio Montisci, Arianna Lanza, Nicola P. M. Casati, Piero Macchi|2020|Inorg.Chem.|59|10091|doi:10.1021/acs.inorgchem.0c01229
DOI: 10.5517/ccdc.csd.cc24srtj
title: CCDC 1990008: Experimental Crystal Structure Determination

description: Related Article: Huifen Hu, Jingjing Pang, Peijun Gong, Lijuan Chen, Junwei Zhao|2020|Inorg.Chem.|59|11287|doi:10.1021/acs.inorgchem.0c00768
DOI: 10.5517/ccdc.csd.cc24srvk
title: CCDC 1990009: Experimental Crystal Structure Determination

description: Related Article: Huifen Hu, Jingjing Pang, Peijun Gong, Lijuan Chen, Junwei Zhao|2020|Inorg.Chem.|59|11287|doi:10.1021/acs.inorgchem.0c00768
DOI: 10.5517/ccdc.csd.cc256lhh
title: CCDC 2002336: Experimental Crystal Structure Determination

description: Related Article: Ariana Z. Spentzos, Michael R. Gau, Patrick J. Carroll, Neil C. Tomson|2020|Chem.Commun.|56|9675|doi:10.1039/D0CC03521A
DOI: 10.5517/ccdc.csd.cc256ljj
title: CCDC 2002337: Experimental Crystal Structure Determination

description: Related Article: Ariana Z. Spentzos, Michael R. Gau, Patrick J. Carroll, Neil C. Tomson|2020|Chem.Commun.|56|9675|doi:10.1039/D0CC03521A
DOI: 10.5517/ccdc.csd.cc256lkk
title: CCDC 2002338: Experimental Crystal Structure Determination

description: Related Article: Ariana Z. Spentzos, Michael R. Gau, Patrick J. Carroll, Neil C. Tomson|2020|Chem.Commun.|56|9675|doi:10.1039/D0CC03521A
DOI: 10.5517/ccdc.csd.cc256lmm
title: CCDC 2002340: Experimental Crystal Structure Determination

description: Related Article: Ariana Z. Spentzos, Michael R. Gau, Patrick J. Carroll, Neil C. Tomson|2020|Chem.Commun.|56|9675|doi:10.1039/D0CC03521A