cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18339188
title: Precision Cascade Engine: Medical Evidence Module (Audit‑Certified Reproducibility Archive)

description: Precision Cascade Engine — Medical Evidence Module v1.0.0

 

Audit‑Certified Reproducibility Archive

 

Abstract

 

This record publishes the Precision Cascade Medical Evidence Module v1.0.0: a deterministic, audit‑certified infrastructure for handling clinical, genomic, and medical‑device evidence.

 

The module standardises integrity, provenance, validation, and auditability for medical evidence without diagnosing conditions, interpreting results, or making clinical decisions. It converts raw medical data into canonical, reproducible evidence objects governed by explicit rules for validation, tolerance, uncertainty handling, and tampering detection.

 

The archive demonstrates audit‑grade reproducibility for genomic sequencing workflows and medical‑device telemetry, establishing a general medical‑evidence truth infrastructure suitable for laboratories, regulators, manufacturers, and research environments.

 

-

 

Description

 

Overview

 

This archive provides a medical‑evidence infrastructure built on the Precision Cascade Engine. It focuses exclusively on evidence integrity, provenance, and reproducibility, not on clinical judgment or decision‑making.

 

Scope

 

Supported evidence domains include:

 

• clinical and operational records

• genomic sequencing evidence

• medical‑device telemetry

• regulatory and compliance documentation

 

 

Reference Cases

 

The archive includes two fully audited, deterministic reference cases:

 

• genomic evidence integrity (whole‑exome sequencing)

• implantable medical‑device telemetry provenance

 

 

Each reference case includes golden outputs, audit scripts, integrity manifests, and replication kits.

 

Relationship to the Core Engine

 

This module is derived from the Precision Cascade Cosmology Engine’s scientific core. It extends the engine through medical‑domain adapters but does not modify the underlying architecture.
DOI: 10.5061/dryad.6k58bt3
title: Data from: Toward a precision behavioral medicine approach to addressing high-risk sun exposure: a qualitative analysis

description: Objectives: Precision behavioral medicine techniques integrating wearable
 ultraviolet radiation (UVR) sensors may help individuals avoid sun
 exposure that places them at-risk for skin cancer. As a preliminary step
 in our patient-centered process of developing a just-in-time adaptive
 intervention, this study evaluated reactions and preferences to UVR
 sensors among melanoma survivors. Materials and Methods: Early stage adult
 melanoma survivors were recruited for a focus group (n=11) or 10-day
 observational study, which included daily wearing a UVR sensor and sun
 exposure surveys (n=39). Both the focus group moderator guide and
 observational study exit interviews included questions on UVR sensing as a
 potential intervention strategy. These responses were transcribed and
 coded using an inductive strategy. Results: Most observational study
 participants (84.6%) said they would find information provided by UVR
 sensors to be useful to help them learn about how specific conditions
 (e.g., clouds, location) impact sun exposure and provide in-the-moment
 alerts. Focus group participants expressed enthusiasm for UVR information
 and identified preferred qualities of a UVR sensor, such as small size and
 integration with other devices. Participants in both studies indicated
 concern that UVR feedback may be difficult to interpret and some expressed
 that a UVR sensor may not be convenient or desirable to wear in daily
 life. Discussion: Melanoma survivors believe that personalized UVR
 exposure information could improve their sun protection and want this
 information delivered in a method that is meaningful and actionable.
 Conclusion: UVR sensing is a promising component of a precision behavioral
 medicine strategy to reduce skin cancer risk.
description: UVR Sensor Exit
 Interview Responses
DOI: 10.5061/dryad.7dj6850
title: Data from: Divergent evolutionary morphology of the axial skeleton as a potential key innovation in modern cetaceans

description: Cetaceans represent the most diverse clade of extant marine tetrapods.
 Although restructuring of oceans could have contributed to their
 diversity, other factors might also be involved. Similar to ichthyosaurs
 and sharks, variation of morphological traits could have promoted the
 colonization of new ecological niches and supported their diversification.
 By combining morphological data describing the axial skeleton of 73
 cetacean species with phylogenetic comparative methods, we demonstrate
 that the vertebral morphology of cetaceans is associated to their habitat.
 All riverine and coastal species possess a small body size, lengthened
 vertebrae and a low vertebral count compared to open ocean species. Extant
 cetaceans have followed two distinct evolutionary pathways relative to
 their ecology. Whereas most offshore species such as baleen whales evolved
 towards an increased body size while retaining a low vertebral count,
 small oceanic dolphins underwent deep modifications of their axial
 skeleton with an extremely high number of short vertebrae. Our comparative
 analyses provide evidence these vertebral modifications have potentially
 operated as key innovations. These novelties contributed to their
 explosive radiation, resulting in an efficient swimming style that
 provides energetic advantages to small-sized species.
description: Vertebral count of
 cetaceansCetacean vertebral
 counts per speciesVertebral_count.xlsxVertebral shape of cetaceansRaw linear and angular measurements on vertebrae of cetaceans.Vertebral_shape.xlsx
DOI: 10.5061/dryad.18tk64p
title: Data from: ZmIBH1-1 regulates plant architecture in maize

description: Leaf angle (LA) is a critical agronomic trait which affects grain yield
 through planting density in maize. Much research has been conducted in
 recent years to investigate the genes responsible for LA variation and a
 few genes were identified through map-based cloning. Here we cloned the
 ZmIBH1-1 gene, which is a bHLH transcription factor with both a basic
 binding region and a Helix-Loop-Helix domain; and qRT-PCR results showed
 that ZmIBH1-1 is a negative regulator of LA in maize. Histological
 analysis showed that the change in LA was mainly caused by differential
 cell wall lignification and cell elongation in the ligular region. To
 reveal the regulatory framework of ZmIBH1-1, we conducted RNA-Seq and
 DAP-Seq analysis. Overlay of the RNA-Seq and DAP-Seq results revealed 59
 ZmIBH1-1 modulated target genes with annotation, and they were mainly cell
 wall related, cell development or hormone related genes. We have built a
 new regulatory model of ZmIBH1-1 gene controlling plant architecture in
 maize.
description: Supplementary figure1. Sequence alignment of Yu82 and Yu87-1.
 Polymorphisms are highlighted in cyan and the predicted translation start
 of ZmIBH1-1 is boxed in yellow and the predicted termination codon of
 ZmIBH1-1 is boxed in red. Supplementary figure 2.
 Protein sequence alignment of ZmIBH1-1 and SvIBH1-1. Red squares indicate
 the conserved bHLH domain. '*' indicates positions which have a
 single, fully conserved residue. ':' indicates that one of the
 following 'strong' groups is fully conserved: STA, NEQK, NHQK,
 NDEQ, QHRK, MILV, MILF, HY, and FYW. '.' indicates that one of
 the following 'weaker' groups is fully conserved: CSA, ATV, SAG,
 STNK, STPA, SGND, SNDEQK, NDEQHK, NEQHRK, FVLIM, and HFY.
 Supplementary figure 3. Results of the dual-luciferase transient
 transcriptional activity assay. (A) The 35S:REN-Pro zein:LUC reporter
 constructs were transiently expressed in onion epidermal cells together
 with control vector or 35S:ZmIBH1-1effector, respectively. (B) The
 expression level of Renilla (REN) was used as an internal control. The
 LUC/REN ratio represents the relative activity of candidate gene
 promoters. Data are values of three independent experiments. Significant
 differences from the corresponding control values (using Student’s t test
 [n = 3]): *P &lt; 0.05, **P &lt; 0.01, and ***P &lt;
 0.001.
DOI: 10.21227/f7ax-s197
title: "Experimental Dataset of Series-Connected INR18650-30Q Lithium-Ion Cells under CC\u2013CV Charging and Resistive Discharge Cycles"

description: "This dataset contains 60 CSV files, comprising 30 charging test files and 30 discharging test files. In all experimental tests, four lithium-ion cells of the INR18650-30Q model were connected in series, with a nominal voltage of 4.2 V and a nominal capacity of 3000 mAh. It is important to note that all cells used in the experiments were new, presenting a state of health (SOH) of 100%.The charging tests were performed using the constant current\u2013constant voltage (CC\u2013CV) method, as described below:Charging files numbered from 1 to 10: charging with a current of 1 A;Charging files numbered from 11 to 20: charging with a current of 2 A;Charging files numbered from 21 to 30: charging with a current of 3 A.The discharging tests were conducted using fixed resistive loads and are organized as follows:Discharging files numbered from 1 to 10: discharging with a fixed load of 16.8 \u03a9 and an initial current of approximately 1 A;Discharging files numbered from 11 to 20: discharging with a fixed load of 8.4 \u03a9 and an initial current of approximately 2 A;Discharging files numbered from 21 to 30: discharging with a fixed load of 5.6 \u03a9 and an initial current of approximately 3 A.Each discharging cycle starts with all cells fully charged to 4.2 V and ends when the cell voltage reaches the lower cut-off limit of 3 V.During each experimental cycle, the following parameters were recorded:Individual voltage of each cell;Surface temperature of cells 3 and 4;Charging or discharging current.Data acquisition was performed using an ESP32 microcontroller connected to an ADS1115 analog-to-digital converter. Voltage measurements were obtained through voltage dividers connected to the ADS1115. Charging and discharging currents were measured using a LAH50-P (50 A) current sensor, while the surface temperature of the cells was monitored using a DS18B20 sensor. The current and temperature sensors were connected directly to the ESP32.The ESP32 was connected to a computer via a serial interface, and the data were visualized in real time using MATLAB software."
DOI: 10.5061/dryad.v75qf08
title: Data from: Comparative crystallography suggests maniraptoran theropod affinities for latest Cretaceous European ‘geckoid’ eggshell

description: Thin fossil eggshells from Upper Cretaceous deposits of Europe,
 characterized by nodular ornamentation similar to modern gekkotan
 eggshells, have mostly been interpreted as gekkotan (=‘geckoid’) in
 origin. However, in some cases, like the oogenus Pseudogeckoolithus, their
 theropod affinity was also suggested. The true affinity of these fossil
 ‘geckoid’ eggshells remained controversial due to the absence of
 analytical methods effective in identifying genuine gecko eggshells in the
 fossil record. In this study, we apply electron backscatter diffraction
 (EBSD) analysis to latest Cretaceous European 'geckoid'
 (including Pseudogeckoolithus) eggshells, in comparison with modern
 gekkotan and theropod (avian) eggshells. Our results show that
 Pseudogeckoolithus has a definite theropod eggshell-like crystallographic
 configuration, in clear contrast to that seen in modern geckos.
 Furthermore, the crystallography of the nodular ornamentation in
 Pseudogeckoolithus is comparable to that seen in megapode eggshells, but
 different from that of gecko eggshells, despite superficial morphological
 similarity. The remarkable morphological similarities between
 Pseudogeckoolithus and modern gecko eggshells are thus convergent, and the
 ‘gekkotan affinity’ hypothesis can be dismissed for Pseudogeckoolithus.
 This study provides a template for differentiating true gekkotan from
 dinosaurian eggshells in the fossil record. The potential functional
 significance of eggshell ornamentation, lost in most modern birds,
 requires further study, and experimental zoological approach may shed
 light on this issue. Finally, our results caution about the dangers of
 using potentially homoplastic eggshell characters in eggshell
 parataxonomy.
description: Iharkut
 PseudogeckoolithusRaw data of Iharkut
 (Hungary) PseudogeckoolithusIharkut
 PseudogeckoolithusPetresti
 PseudogeckoolithusRaw data for Petresti
 (Romanian) PseudogeckoolithusPetresti
 PseudogeckoolithusValioara
 PseudogeckoolithusRaw data for Valioara
 (Romanian) PseudogeckoolithusValioara
 PseudogeckoolithusPui
 PsedogeckoolithusRaw data for Pui
 (Romania) PsedogeckoolithusPui
 PsedogeckoolithusBlasi 2
 PseudogeckoolithusRaw data for Blasi 2
 (Spain) PseudogeckoolithusBlasi 2
 PseudogeckoolithusGecko (Gekko
 gecko)Raw data for Gekko gecko
 (Gekkota) eggshellGecko (Gekko
 gecko)Gecko (Phelsuma
 grandis)Raw data for Phelsuma
 grandis (Gekkota) eggshellGecko (Phelsuma
 grandis)Emu (Dromaius
 novaehollandiae)Raw data for Dromaius
 novaehollandiae (Palaeognathae) eggshellEmu (Dromaius
 novaehollandiae)Duck (Anas
 platyrhynchos)Raw data for Anas
 platyrhynchos (Neognathae) eggshellDuck (Anas
 platyrhynchos)Supplementary texts and
 figuresSupplementary
 Information (texts and figures) cited in the main text.Supplementary
 tablesSupplementary tables
 cited in the main and supplementary text.Supplementary texts and
 figuresSupplementary
 Information (texts and figures) cited in the main text.
DOI: 10.5061/dryad.6472vq6
title: Data from: Seasonal shifts in feeding patterns: individual and population realized specialization in a high Arctic fish

description: Species with a broad and flexible diet may be at an advantage in a rapidly
 changing environment such as in today’s Arctic ecosystems. Polar cod
 (Boreogadus saida), an abundant and ecologically important circumpolar
 Arctic fish, is often described as a zooplankton generalist feeder, which
 suggests that it may cope successfully with changes in prey composition.
 This description is justified based on the relatively broad diet of polar
 cod across sites and seasons. In this case study, we used polar cod
 dietary data from fall and winter and from two distinct environments,
 dominated either by Arctic or Atlantic water masses in Svalbard. Our
 results point to the importance of time and space when drawing conclusions
 on dietary plasticity and degree of specialization. Polar cod diet
 differed significantly between fall and the winter and between Arctic and
 Atlantic domains. Polar cod from Arctic domains displayed a strong
 realized population specialization on T.libellua in fall, and the larger
 dietary niche width observed in the winter was the product of realized
 individual specialization, with increased feeding on fish prey. Overall,
 we did not observe a generalized feeding behavior. If dietary niche width
 is to inform conservation management, we argue it must be recognized that
 populations from a single species may adopt seasonally contrasting degrees
 of dietary specialization and that these populations may differ in their
 vulnerability to climate-induced changes in prey community composition.
description: Seasonal gravimetric
 stomach content of Boreogadus saida from SvalbardThis file contains data
 from the stomach content of polar cod (Boreogadus saida) in grams. The ID
 number corresponds to a single individual. The dissected stomachs were
 examined with a dissecting microscope and prey taxa were identified to the
 lowest possible taxonomic level. Individuals of each prey taxa were
 weighed. Some taxonomic levels were grouped into broader dietary
 categories for the analyses. The season "FALL" corresponds to
 September and October, and "WINTER" corresponds to January. The
 data was collected in the fall 2014 and 2015, and in the winter 2015 and
 2016. The sites are all situated in the Svalbard archipelago and are the
 following: "BILL" for Billefjorden, "RIJP" for
 Rijpfjorden, and "SMEE" for Smeerenburg.Cusa_Data.xlsx
DOI: 10.5061/dryad.g9t361s
title: Data from: Disentangling the fundamental branching patterns of phylogenetic divergence to refine eco-phylogenetic analyses

description: Aim: Previous studies have shown that phylogenetic divergence (i.e. the
 average phylogenetic displacement between species in a community) is
 highly sensitive to the underlying branching patterns of phylogenies,
 suggesting that there is a need to integrate both facets of phylogenic
 information to obtain a better understanding of assemblage structure.
 Here, we formally conceptualize the three fundamental branching patterns
 that can drive phylogenetic divergence, and propose a method to identify
 their signature in the communities based on the MPD (mean pairwise
 distance) metric. Location: Global. Taxa: All. Methods: Our approach
 consists on the joint interpretation of two MPD-derived metrics that
 summarize the differential contribution of individual phylogenetic
 branches to the observed divergence, which serves to evaluate to what
 extent the later emerges from contrasting branching patterns. We conduct
 simulation analyses to compare our two metrics with eight classical
 descriptors of phylogenetic structure, and use multi-strata tropical plant
 communities along a gradient of land-use intensity (LUI) to further
 illustrate our method. Results: As expected, our metrics correlated to
 some extent with the classical descriptors of phylogenetic structure,
 although the relationships were complex and varied systematically with
 species richness and the specific combination of metric values considered.
 Consequently, the information provided by our two indexes was only
 partially captured by their most correlated classical descriptors. We
 detected differential signatures of the fundamental branching patterns in
 our real-world dataset, either across vegetation strata and also within
 strata along the LUI gradient, which provided greater insight into
 potential assembly mechanisms. Main conclusions: While the sole use of
 phylogenetic divergence may lead to spurious interpretations in
 eco-phylogenetic studies, our approach can help to obtain a better
 understanding of assemblage structure by systematically analyzing
 phylogenetic divergence in the light of its fundamental branching
 patterns.
description: DatasetThe zip file includes (i) presence/absences of species per plot and vegetation stratum, (ii) the LUI index and (iii) the phylogeny used in the analyses.
DOI: 10.5061/dryad.fr9305r
title: Data from: Understanding families' experiences following a diagnosis of non-syndromic Craniosynostosis: A qualitative study

description: Objectives: Craniosynostosis, a congenital anomaly producing an abnormal
 cranial morphology, is typically diagnosed and surgically corrected within
 the first year of life. Given the young age of this patient population at
 the time of diagnosis, it is reasonable to expect this experience to be a
 very significant and stressful ordeal for patient families. Despite this,
 there is little research exploring the impact that craniosynostosis has on
 families, especially in the early stages. In this study, the authors aimed
 to qualitatively examine the psychosocial experience of families with a
 child diagnosed with craniosynostosis. Design: Qualitative study. Setting:
 Tertiary care paediatric health centre. Participants: Parents of children
 newly diagnosed with single-suture, non-syndromic craniosynostosis
 Intervention: Semistructured interviews regarding parental experience with
 the initial diagnosis, their decision on corrective surgery for their
 child, the operative experience, the impact of craniosynostosis on the
 family and the challenges they encountered throughout their journey.
 Primary and Secondary Outcome Measures: Interpretive phenomenological
 analysis, a type of qualitative analysis that provides an in-depth account
 of participant’s experiences and their meanings, was used to analyze the
 interview data. Results: Over a four-year period, twelve families meeting
 eligibility criteria completed the study. Three main themes (6 subthemes)
 emerged from the pre-operative interviews: frustration with diagnostic
 delays (parental intuition and advocacy, hope for improved awareness),
 understanding what to expect (healthcare supports, interest in connecting
 with other families), and justifying the need for corrective surgery
 (influence of the surgeon, struggle with cosmetic indications). Two main
 themes (4 subthemes) were drawn from the post-operative interviews:
 pushing through fear (the role of healthcare professionals, transition
 home) and relief (reduction in parental anxiety, cosmetic improvements).
 Conclusions: Overall, the diagnosis of craniosynostosis has a profound
 impact on families, leading them to face many struggles throughout their
 journey. A better understanding of these experiences will help to inform
 future practice, with a hope to improve this experience for other families
 moving forward.
description: Transcripts from
 qualitative craniosynostosis studyTranscripts.docx
DOI: 10.5061/dryad.2f82381
title: Data from: An fMRI-based neural marker for migraine without aura

description: Objective: To identify and validate a functional magnetic resonance
 imaging (fMRI)-based neural marker for migraine without aura (MwoA) and
 examine its association with treatment response. Methods: Cross-sectional
 studies with resting-state fMRI data from 230 participants and machine
 learning analyses were conducted. In Studies 1-3, we identified,
 cross-validated, independently validated, and cross-sectionally validated
 an fMRI-based neural marker for MwoA. In Study 4, we assessed the
 relationship between the neural marker and treatment responses in
 migraineurs who received a 4-week acupuncture treatment in a registered
 clinical trial. Results: In Study 1 (n = 116), we identified a neural
 marker with abnormal functional connectivity within the visual, default
 mode, sensorimotor, and frontal-parietal networks that could discriminate
 migraineurs from healthy controls (HCs) with 93% sensitivity and 89%
 specificity. In Study 2 (n = 38), we investigated the generalizability of
 the marker by applying it on an independent cohort of migraineurs and HCs
 and achieved 84% sensitivity and specificity. In Study 3 (n = 76), we
 verified the specificity of the marker with new datasets of migraineurs
 and other chronic pain disorders (chronic low back pain and fibromyalgia)
 and demonstrated 78% sensitivity and 76% specificity for discriminating
 migraineurs from non-migraineurs. In Study 4 (n = 116), we found that the
 changes in the marker responses showed significant correlation with the
 changes in headache frequency in response to real acupuncture. Conclusion:
 We identified an fMRI-based neural marker that captures distinct
 characteristics of MwoA and can link disease pattern changes to brain
 changes.
description: Supplement for "An
 fMRI-based neural marker for migraine without aura"Supplementary
 material_0802.docx