cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17026/dans-x38-pz3s
title: The STELLAR trial: A phase II/III study of high-dose, intermittent sunitinib in patients with recurrent glioblastoma

description: These data support the main findings described in 'The STELLAR trial: A phase II/III study of high-dose, intermittent sunitinib in patients with recurrent glioblastoma.The data contains the results from the STELLAR trial, registered on ClinicalTrials.gov (NCT03025893). In total 55 patients were randomized 1:1 between treatment with high-dose intermittent sunitinib (either 300mg Q1W or 700mg Q2W) and lomustine. The trial was performed in three centers in the Netherlands (AmsterdamUMC, UMCG and Radboudumc).
DOI: 10.17026/dans-x4f-tf34
title: ZonMW project: Optimalisatie gebruik generieke PROMs als basis voor Samen Beslissen

description: In het Amsterdam UMC hebben we geruime tijd ervaring met het implementeren van PROMs (Patient Reported Outcome Measures, vragenlijsten) in de spreekkamer. Daarnaast is er al veel kennis beschikbaar over Samen Beslissen. In dit project wilden we inzicht krijgen in hoe deze twee onderdelen van passende zorg elkaar kunnen versterken. Hiervoor hadden we drie doelen:1. Inzicht in daadwerkelijk gebruik PROMs en ervaringen van patiënt en zorgprofessional dmv het opnemen van consulten en het houden van evaluatiegesprekken.2. Input over dashboarding van generieke PROMs vanuit patiëntenperspectief dmv het houden van focusgroepen3. Het verbeteren van het gebruik van PROMs in het proces van samen beslissen dmv het organiseren van een symposium en webinar en gesprekken te voeren met experts op het gebied van PROMs en Samen Beslissen.
DOI: 10.17026/dans-x96-83k8
title: Saliva sample results in healthy subjects in the Controlled Environmental Research Laboratory

description: Thirty-four healthy subjects, 20 male, 14 female, median age 35.44 years (range 30-40) were exposed for 30 minutes under standard environmental conditions (T: 22 ºC, 50% relative humidity) in the Controlled Environmental Research Laboratory (CE-Lab, Vision R&D, Valladolid Spain) in two separate visits (V1, V2) at least 24 hours apart. Saliva was collected after the exposure in each of the visits, and cortisol, α-amylase (sAA), secretory IgA (sIgA), testosterone, and soluble fraction of TNFα receptor II (sTNFαRII) were analyzed by ELISA.
DOI: 10.17026/dans-x9u-huca
title: The uniqueness and overlap of the EQ-HWB and the EQ-5D-5L in four diseases, healthy subjects, and caregivers

description: IntroductionThe EuroQol Health and Well-Being (EQ-HWB) is a generic quality of life questionnaire in development, to capture more detailed aspects of health and well-being than EQ-5D-5L. This paper examines the measurement properties and factor structure of the EQ-HWB in comparison with the EQ-5D-5L.MethodsRespondents (i) with or without caregiver tasks, and (ii) with different diseases, or (iii) in full health, were recruited online. Ceiling effects, convergent validity and divergent validity, known disease and caregiver group differences were explored and an explorative factor analysis employed.Results500 respondents were recruited, of whom 140 were healthy people, 122 with chronic hepatitis B (CHB), 101 with HIV_AIDS, 107 with major depressive disorder (depression), 90 with generalized anxiety order (GAD), and 40 healthy responders were also a caregiver (responders can have more than one health problem). EQ-HWB had a lower ceiling effect than EQ-5D-5L. The highest correlations between the EQ-HWB activities dimension and EQ-5D-5L were in the dimensions: mobility, self-care, and usual activities. The EQ-HWB physical sensation is most related to the EQ-5D-5L pain dimension. The remaining well-being EQ-WHB dimensions were most related to the EQ-5D-5L anxiety and depression dimension. EQ-5D-5L and EQ-HWB could identify differences in the diseases and caregiving burdens across healthy people, physical and mental disease patients, and healthy caregivers. Explorative factor analyses reveal 5 meaningful factors.ConclusionEQ-HWB can differentiate well-being in more detail than EQ-5D-5L, and has the advantages that it can measure relevant outcomes across healthcare, social care, and public health.
DOI: 10.17026/dans-xa2-awem
title: Clarithromycin use for adjunct surgical prophylaxis before non-elective cesarean deliveries to adapt to azithromycin shortages in COVID-19 pandemic

description: Dataset for research study "Clarithromycin use for adjunct surgical prophylaxis before non-elective cesarean deliveries to adapt to azithromycin shortages in COVID-19 pandemic ". This is clinical data which is de-identified.
DOI: 10.17026/dans-xd2-3zpg
title: ARTICA RCT primary outcome

description: BACKGROUND: Patients with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are routinely transferred to theemergency department (ED). A clinical risk score with point-of-care (POC) troponin measurement might enable ambulance paramedics to identify low-risk patients in whom ED evaluation is unnecessary. The aim was to assess safety and healthcare costs of a pre-hospital rule-out strategy using a POC troponin measurement in low-risk suspected NSTE-ACS patients.METHODS AND RESULTS:This investigator-initiated, randomized clinical trial was conducted in five ambulance regions in the Netherlands. Suspected NSTE-ACS patients with HEAR (History, ECG, Age, Risk factors) score ≤3 were randomized to pre-hospital rule-out with POC troponin measurement or direct transfer to the ED. The sample size calculation was based on the primary outcome of 30-day healthcare costs. Secondary outcome was safety, defined as 30-day major adverse cardiac events (MACE), consisting of ACS, unplanned revascularization or all-cause death. : A total of 863 participants were randomized. Healthcare costs were significantly lower in the pre-hospital strategy (€1349±€2051 vs. €1960±€1808) with a mean difference of €611 [95% confidence interval (CI): 353–869; P&lt;0.001]. In the total population, MACE were comparable between groups [3.9% (17/434) in pre-hospital strategy vs. 3.7% (16/429) in ED strategy; P= 0.89]. In the ruled-out ACS population, MACE were very low [0.5% (2/419) vs. 1.0% (4/417)], with a risk difference of −0.5% (95% CI −1.6%–0.7%; P=0.41) in favour of the pre-hospital strategy.CONCLUSION:Pre-hospital rule-out of ACS with a POC troponin measurement in low-risk patients significantly reduces healthcare costswhile incidence of major adverse cardiac events was low in both strategies
DOI: 10.17026/dans-xmk-twgb
title: Implementation of Pelvic Floor Rehabilitation after rectal cancer surgery

description: Implementation of Pelvic Floor Rehabilitation after rectal cancer surgery. A qualitative study guided by the ConsolidatedFramework for Implementation Research (CFIR) .
DOI: 10.17026/dans-xne-pwfn
title: Safety and efficacy of a novel mouth rinse in patients with gingivitis

description: 16S rRNA sequencing data from supragingival microbiome samples used in a single-center, randomized controlled trial aimed to determine the safety and efficacy of a novel mouth rinse in preventing supragingival plaque formation in patients with gingivitis.
DOI: 10.17026/dans-xqw-xbwv
title: A Guided Digital Health Intervention for Depression in Lebanon: Randomized Trial

description: This contains the data collected in the randomised trial examining the effects of the digital intervention Step by Step on depression in people living in Lebanon
DOI: 10.17026/dans-xrs-2zxp
title: Supplement to: van der Tuin K, et al. Clinically-relevant Germline Variants in Children with Non-Medullary Thyroid Cancer

description: Supplement to: van der Tuin K, et al. Clinically-relevant Germline Variants in Children with Non-Medullary Thyroid Cancer
DOI: 10.17026/dans-xrt-du5k
title: Maternal Mental Health and Unintended Motherhood-study

description: Retrospective cohort compiled of 2312 pregnant women who have given birth at OLVG between 2015-2020.
DOI: 10.17026/dans-z2w-vqff
title: Habitat suitability of Unionidae host fish in the Rhine Delta

description: Literature review data belonging to :"Habitat suitability of Unionidae host fish in the Rhine Delta"
DOI: 10.17026/dans-z58-2nxf
title: Workplace Ergonomics Problems and Solutions: Working from Home

description: This study aims to identify the ergonomics issues of working from home and suggest several solutions in minimising these issues. It serves as a guideline to employees and employers in developing healthier WFH conditions. This exploratory study included a focus group discussion among experts from fields of higher education, healthcare, HR and ergonomics. The most common ergonomics issues identified were based on diagnoses and observations from previous studies. The panellists agreed on the issues which comprised the use of unergonomic chairs, incorrect sitting postures, irregular arrangement of key objects, improper reach distances of the laptop/keyboard/mouse, poor desk designs, absence of footrest, distortion/noise, poor lighting and poor work environment.
DOI: 10.17026/dans-z5y-k9ry
title: Data with Rewilding the sea with domesticated seagrass

description: Data compilation of reproductive traits of seagrass species, including potential seed production, life cycle period and location of seed release, used to calculate their domestication and rewilding potential.
DOI: 10.17026/dans-z7d-v29z
title: Litter Decomposition Root Traits under Simulated Heavy Rainfall Events in Adventdalen, Svalbard

description: Root biomass, root C:N, separated into grass and shrub roots. For the root biomass data, the total weight of the root sample was measured, and the shrub and grass roots separately after dividing them. Then the roots were ground up and a subsample of maximum 3 mg was taken. The C:N was done on the subsample.The data for the litter decomposition bags has been added, containing weight of the bags in pre- and post-burial, for four different litter types (Lipton green tea, shrub litter, grass litter, general local soil organic matter taken from the soil cores).The litter types have each been analysed for their C:N as well. The weight of the litter bags before and after burial wasdetermined for the complete litter bag, which included a mesh bag, 2 staples, 2 coloured beads, and the litter content.
DOI: 10.17026/dans-zaf-h5pv
title: Multicomponent intervention on adherence to school meals: a quasi-experimental study

description: Quasi-experimental study, conducted during 2019 with students from 4th to 9th grade of three public schools in the rural area of Sumidouro, Rio de Janeiro, Brazil: i) control group, ii) experimental group 1 (environmental modifications and addition of a self-service system) and iii) experimental group 2 (environmental modifications, addition of a self-service system and new culinary preparations in the menu based on gastronomic techniques). The weekly frequency of school meals consumption was assessed by a question included in a self-completed questionnaire applied at three moments (baseline, 1st follow-up [after 5 months of intervention] and 2nd follow-up [after 8 months of intervention]). Those students who reported frequency ≥3 times a week were considered adherent to school meals. The variation rate in adherence to school meals in each school was evaluated via generalized linear models.
DOI: 10.17026/dans-zdm-s9r9
title: The effect of MBCT on state and trait rumination in bipolar disorder

description: This data set contains data regarding the paper: The effect of MBCT on state and trait rumination in bipolar disorder
DOI: 10.17026/dans-ze7-w28d
title: Risk visualization in personalised breast cancer screening

description: Due to the emergence of personalized breast cancer screening, it will be possible to categorize women to, for example, low, moderate or high risk profiles in the near future. These profiles will increase the personal relevance of the screening result for women, but also its complexity. Currently, communication of the outcome addresses a dichotomous mammography result (i.e. either abreast abnormality or not). Personalized screening will result in communication of a personalized multifaceted risk message (a): no breast abnormality found;(b) personalized risk profile (low, medium, high risk);(c) corresponding advice for follow-up screening interval. Apart from the question to what extent such risk messages will influence women’s acceptance of the advised follow-up interval, it is essential to know how they will understand this personalized risk message. Adequate comprehension of one’s breast cancer risk is a main precondition for making well-informed further decisions in the screening program. Visualization of risk information seems a promising approach to support risk comprehension in addition to textual/numerical risk information, but visualizations can also generate unwarranted effects, especially among lower health literacy (HL) individuals.This project aims to design and test novel (interactive) visualizations of risk information in personalized breast cancer screening. Specific aims: (1) To gain insight in methods and underlying mechanisms of risk visualizations that support risk comprehension; (2) To design risk visualizations that support comprehension of the personalized multifaceted risk message for each risk profile (low, medium, high risk); (3) To assess the effects of the risk visualizations on risk comprehension (primary outcome), risk perception, worry, anxiety, attitudes towards participation, and hypothetical decisions/intentions regarding the follow-up interval (secondary outcomes).The underlying data and the designed visualizations are not available in dansEasy, but they can be shared upon request (please contact the project leader). The total project protocol is available in DansEasy, as well as the used protocols for interviews and co-creation sessions, all in Dutch. Study 3 of the project (related to aim 3 as described above) has been pregistered in OSF: https://osf.io/r723n
DOI: 10.17026/dans-zf9-atbp
title: Leren en verbeteren in de verpleeghuiszorg

description: In dit ZonMw-project hebben we een actie onderzoek uitgevoerd met als doel om het leren en innoveren van zorgprofessionals in opleiding en gekwalificeerde professionals te stimuleren binnen de Amsterdams verpleeghuiszorg. We hebben onderzocht wat de werkzame ingrediënten waren en hoe we dergelijke initiatieven kunnen opschalen. Het interprofessioneel Leer- en InnovatieNetwerk is als best practice opgezet in twee nieuwe GRZ-praktijken en systematisch geëvalueerd.
DOI: 10.17026/dans-zff-5y4k
title: Feasibility and potential effectiveness of the IdentifEYE training programs to address mental health problems in adults with vision impairment

description: Repeated measures and qualitative data were used to assess feasibility and potential effectiveness of two training programs to address depression and anxiety in adults with vision impairment. The Kirkpatrick model was used as a theoretical framework.
DOI: 10.17026/dans-zhf-zx7m
title: Widespread dominance of methane ebullition over diffusion in freshwater aquaculture ponds

description: Data collected from fishponds in Brazil November 2019 - February 2020, beloging to the paper Vroom et al. (2023).
DOI: 10.17026/dans-zhs-q8et
title: Data to "Environmental impacts of reducing medication waste by redispensing unused oral anticancer drugs: a life cycle assessment"

description: The data belongs to the article titled “Environmental impacts of reducing medication waste by redispensing unused oral anticancer drugs: a life cycle assessment”. For the life cycle assessment, life cycle inventory data is collected. The data stored here are the life cycle inventory tables used to calculate the environmental impacts of quality assurance materials, and OAD packaging. The first file contains the inventory for the main scenarios as described in the article. The second file contains inventory data for a scenario with solvent recovery and an alternative reaction pathway for temozolomide. Additionally, the SPSS syntax used to calculate the environmental impacts per patient per year, based on the one-year multicentre trial is included. In the syntax, different values for API production can be manually adjusted. Specific API production impacts are mentioned in the Supplementary Material of the manuscript.
DOI: 10.17026/dans-zhy-6fdc
title: Data: Determinants of health as predictors for differential antibody responses following SARS-CoV-2 primary and booster vaccination in an at-risk, longitudinal cohort

description: Data for manuscript: Determinants of health as predictors for differential antibody responses following SARS-CoV-2 primary and booster vaccination in an at-risk, longitudinal cohort
DOI: 10.17026/dans-zkm-vmn4
title: Adoption of new medicines in primary care: a comparison between the uptake of new oral anticoagulants and diabetes medicines

description: Direct-acting oral anticoagulants (DOACs) were introduced in 2008 for the treatment of thrombo-embolic diseases. Dipeptidyl peptidase-4 inhibitors (DPP4-inhibitors) and glucagon-like peptide-1 receptor agonists (GLP1-agonists), both incretin-based therapies, were introduced in 2007 and (late) 2006 respectively, for the treatment of type 2 diabetes mellitus (T2DM). This study aimed to gain insight in the uptake, practice variation and correlation in the adoption of DOACs and incretin-based therapiesPrescription data from general practices in the Dutch Nivel Primary Care Database from 2007-2019 were used. Per year 46 to 424 general practices and 179,933 to 1,654,376 patients were included. In 2019, the mean percentage of patients per practice using DOACs or incretin-based therapies was 54.9% and 9.7%, respectively. The intraclass correlation coefficient (ICC) decreased from 0.75 to 0.024 for DOACs and from 0.33 to 0.074 for incretin-based medicines during the study period. No clear correlation was found between the prescription of DOACs and incretin-based therapies.
DOI: 10.17026/dans-zmh-tzn3
title: Foodprint 2.0, v.1

description: Foodprint 2.0 is an updated biophysical simulation model that estimates the agricultural resource requirements of diet patterns. This folder contains README files, step-by-step instructions for users, the model, and supplementary files.
DOI: 10.17026/dans-zmj-kghf
title: Effectiveness of 5 integrated-sensory stimulation program on social-emotional development in preterm infants in China

description: This study aims to examine the effectiveness of the stimulation of 5 integrated-sensory systems programs amongst preterm infants on developmental outcomes including neurodevelopment, social-emotional development, and temperament; and amongst preterm infants' mothers on anxiety, depression, parenting competency, bonding, and their fathers on mental health.These data were collected in three hospitals (mainly in two) in Kunming, China. The preterm infants following with their parents were allocated in the intervention and control groups randomly. There are 98 infants in the intervention group, and 102 in the control group. The baseline data were collected during enrollment, including demographic information, infants' medical records, and parents' mental health. All participants were followed at 1 month, 3 months, and 6 months when the preterm infants reached the correct age, and the data of infants' development, temperament, parents' mental health, maternal parenting competency, and maternal bonding were collected at the corresponding stage.
DOI: 10.17026/dans-zmw-p8pv
title: Data to "The role of the sewer system in estimating urban emissions of chemicals of emerging concern'

description: Dataset related to peer-reviewed article.
DOI: 10.17026/dans-ztg-7bnp
title: Data from: Evaluation of ex-vivo adrenocorticotropic hormone-responsiveness of human fetal testis

description: In our brief report “Evaluation of ex-vivo adrenocorticotropic hormone-responsiveness of human fetal testis” (doi to be provided) we evaluated the Adrenocorticotropic Hormone (ACTH) responsiveness of ex-vivo cultured human fetal testis (HFT) tissue. Human fetal adrenal (HFA) tissue was included as positive control. In this repository, we provide the Supplementary Methods and Supplementary Data.The following Supplementary files are provided:Schroder_2023_Supplementary_Table1.pdf contains Supplementary Table 1, presenting median (full range) steroid hormone concentrations (nmol/L) in culture media of ex vivo cultured HFA and HFT tissue fragments (n=6). Culture media was collected after an initial 24-hour culture period and after two subsequent 48-hour periods of culture with or without exposure to 10 nM ACTH. Ratios between the ACTH-exposed and control condition are provided (ACTH/Media).Schroder_2023_Supplementary_Table2.pdf contains Supplementary Table 2, presenting Median (full range) normalized steroid hormone levels relative to baseline steroid hormone levels (24 hours of initial culture) quantified in conditioned culture media of HFA tissue fragments and HFT tissue fragments cultured with or without exposure to 10 nM ACTH.Schroder_2023_Supplementary_Figure1.pdf contains Supplementary Figure 1, presenting Hematoxylin and Eosin staining of ex-vivo cultured Fetal Testis (A) and Fetal Adrenal (B) fragments fixed (4% normal buffered formalin) either prior to culture (preculture control [PCC]), or after 5 days of culture with four days of 10 nM ACTH treatment or basal control.Schroder_2023_Supplementary_Figure2.pdf contains Supplementary Figure 2, presenting normalized steroid hormone levels in culture media collected after a second 48-hour period of ex-vivo culture of HFA tissue fragments and HFT tissue fragments with or without exposure to 10 nM ACTH. Steroid hormone levels were normalized for steroid hormone levels in culture media collected after a preceding 24-hour basal culture period without ACTH exposure. Data of individual biological replicates (n=6) are presented with unique symbols.Schroder_2023_Supplementary_Methods contains Supplementary Methods on the Liquid Chromatography tandem mass spectrometry (LC-MS/MS) method to quantify steroid hormones in culture media and on the quantitative polymerase chain reaction (qPCR) to confirm male sex.Abbreviations: 11dF, 11-deoxycortisol; 17OHP, 17-hydroxyprogesterone; A4, Androstenedione; ACTH; Adrenocorticotropic hormone; F, Cortisol; HFA, human fetal adrenal; HFT, human fetal testis; T, Testosterone; A4, Androstenedione.
DOI: 10.17026/dans-zvf-ad57
title: mHealth_CHW_dataset

description: This is a dataset containing data for Community Health Workers in a refugee setting
DOI: 10.17026/dans-zvh-wgj7
title: Data_MichielBontje_ArcticFieldGrant

description: This dataset contains plant phenology, nitrogen content and herbivory data gathered on Svalbard during the T-REX project in 2023, see: https://www.researchinsvalbard.no/project/a2960000-1219-0a01-39d2-08da0b200c42/project-infoThe research sites where located in Adventdalen (location 1 and 2), Endalen (location 3 and 4) and Ny-Alesund (Location 5).For the MSc thesis of Michiel Bontje.