cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17028/rd.lboro.5493136
title: Study Habits and Attainment in Undergraduate Mathematics: A Social Network Analysis - dataset

description: This record contains the data for the paper: Study Habits and Attainment in Undergraduate Mathematics: A Social Network Analysis.<br>The database contains attribute data (gender, independent and collaborative study hours, A-level results, first year or other modules results) and network measures.<br>We are unable to make this data publicly available. The survey used in the research can be found at: https://doi.org/10.17028/rd.lboro.5505364<br><br>Contact members of the project team for more information.
DOI: 10.17028/rd.lboro.5493136.v1
title: Study Habits and Attainment in Undergraduate Mathematics: A Social Network Analysis - dataset

description: This record contains the data for the paper: Study Habits and Attainment in Undergraduate Mathematics: A Social Network Analysis.<br>The database contains attribute data (gender, independent and collaborative study hours, A-level results, first year or other modules results) and network measures.<br>We are unable to make this data publicly available. The survey used in the research can be found at: https://doi.org/10.17028/rd.lboro.5505364<br><br>Contact members of the project team for more information.
DOI: 10.6084/m9.figshare.5493133
title: Hypothesis, analysis and synthesis: it’s all Greek to me!

description: Collections of terms in PubMed with frequency analysis and etymological definitions -- Data supplements for the manuscript "Hypothesis, analysis and synthesis, it's all Greek to me" by Ioannis Iliopoulos, Sophia Ananiadou, Antoine Danchin, John PA Ioannidis, Peter D Katsikis, Christos A Ouzounis, Vasilis J Promponas (eLife: 8, e43514) (2019).<br>Data Supplement (DS): File 1 (DS01): The 243 words that appeared in at least one million PubMed records as of July 28, 2018. The words are ranked by number of appearances (second column). File 2 (DS02): The 172 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) that appeared in at least one million PubMed records as of July 28, 2018. File 3 (DS03): The 152 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018. File 4 (DS04): A search string containing the 152 words with rich meaning (that is, nouns, adjectives and verb forms) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018.
DOI: 10.6084/m9.figshare.5493067
title: Demographic And Clinical Features Of Atrial Myxomas: A Case Series Analysis

description: Demographic And Clinical Features Of Atrial Myxomas: A Case Series Analysis
DOI: 10.6084/m9.figshare.5493067.v1
title: Demographic And Clinical Features Of Atrial Myxomas: A Case Series Analysis

description: Demographic And Clinical Features Of Atrial Myxomas: A Case Series Analysis
DOI: 10.6084/m9.figshare.5493133.v1
title: Hypothesis, analysis and synthesis: it’s all Greek to me!

description: Collections of terms in PubMed with frequency analysis and etymological definitions -- submitted manuscript (2018), in review (2019)<br>
DOI: 10.6084/m9.figshare.5492971
title: Readme

description: Readme file.<br>
DOI: 10.6084/m9.figshare.5493001
title: Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus)

description: Gene expression data from whole inner ears of juvenile Eptesicus fuscus (big brown bats) whose ages were estimated using forearm length. Otic capsules were flash frozen in liquid nitrogen, homogenized while frozen, and RNA was extracted using Ambion's mirVana kit.
DOI: 10.6084/m9.figshare.5492971.v1
title: Readme

description: Readme file.<br>
DOI: 10.6084/m9.figshare.5493001.v1
title: Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus)

description: Gene expression data from whole inner ears of juvenile Eptesicus fuscus (big brown bats) whose ages were estimated using forearm length. Otic capsules were flash frozen in liquid nitrogen, homogenized while frozen, and RNA was extracted using Ambion's mirVana kit.
DOI: 10.6084/m9.figshare.5493133.v2
title: Hypothesis, analysis and synthesis: it’s all Greek to me!

description: Collections of terms in PubMed with frequency analysis and etymological definitions -- submitted manuscript (2018), in review (2019)<br>Data Supplement (DS): File 1 (DS01): The 243 words that appeared in at least one million PubMed records as of July 28, 2018. The words are ranked by number of appearances (second column). File 2 (DS02): The 172 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) that appeared in at least one million PubMed records as of July 28, 2018. File 3 (DS03): The 152 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018. File 4 (DS04): A search string containing the 152 words with rich meaning (that is, nouns, adjectives and verb forms) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018.
DOI: 10.6084/m9.figshare.5493133.v4
title: Hypothesis, analysis and synthesis: it’s all Greek to me!

description: Collections of terms in PubMed with frequency analysis and etymological definitions -- Data supplements for the manuscript "Hypothesis, analysis and synthesis, it's all Greek to me" by Ioannis Iliopoulos, Sophia Ananiadou, Antoine Danchin, John PA Ioannidis, Peter D Katsikis, Christos A Ouzounis, Vasilis J Promponas (eLife: 8, e43514) (2019).<br>Data Supplement (DS): File 1 (DS01): The 243 words that appeared in at least one million PubMed records as of July 28, 2018. The words are ranked by number of appearances (second column). File 2 (DS02): The 172 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) that appeared in at least one million PubMed records as of July 28, 2018. File 3 (DS03): The 152 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018. File 4 (DS04): A search string containing the 152 words with rich meaning (that is, nouns, adjectives and verb forms) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018.
DOI: 10.6084/m9.figshare.5493133.v3
title: Hypothesis, analysis and synthesis: it’s all Greek to me!

description: Collections of terms in PubMed with frequency analysis and etymological definitions -- Data supplements for the manuscript "Hypothesis, analysis and synthesis, it's all Greek to me" by Ioannis Iliopoulos, Sophia Ananiadou, Antoine Danchin, John PA Ioannidis, Peter D Katsikis, Christos A Ouzounis, Vasilis J Promponas (eLife: 8, e43514) (2019).<br>Data Supplement (DS): File 1 (DS01): The 243 words that appeared in at least one million PubMed records as of July 28, 2018. The words are ranked by number of appearances (second column). File 2 (DS02): The 172 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) that appeared in at least one million PubMed records as of July 28, 2018. File 3 (DS03): The 152 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018. File 4 (DS04): A search string containing the 152 words with rich meaning (that is, nouns, adjectives and verb forms) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018.
DOI: 10.6084/m9.figshare.5492950
title: Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients

description: <b>Objective:</b> Arachidonic acid metabolism by cytochrome P450 (CYP) epoxygenases leads to epoxyeicosatrienoic acids (EETs), which are eicosanoids with vasodilator and anti-inflammatory properties. We aim to determine whether genetic variability in these routes may contribute to cardiovascular (CV) risk in renal transplant recipients. <b>Methods:</b> In a cohort of 355 patients, we determined the presence of two polymorphisms, <i>CYP2C8*3</i> and <i>CYP2J2*7</i>, known to affect eicosanoid levels. Associations with CV mortality, CV event-free long-term survival and graft survival were retrospectively investigated by logistic regression models. <b>Results:</b><i>CYP2J2*7</i> showed a statistical trend towards higher CV mortality (<i>p</i> = .06) and lower cardiac or cerebral event-free long-term survival (<i>p</i> = .05), whilst <i>CYP2C8*3</i> displayed a significant inverse association with the risk of CV event (hazard ratio [HR] = 0.34 [0.15–0.78], <i>p</i> = .01). The association of <i>CYP2J2*7</i> with CV mortality became significant when the analysis was restrained to 316 patients without a history of CV events prior to transplantation (HR = 15.72 [2.83–91.94], <i>p</i> = .005). In this subgroup of patients both single nucleotide polymorphisms (SNPs) were significantly associated with event-free survival. HR values were 5.44 (1.60–18.51), <i>p</i> = .007 and 0.26 (0.09–0.75), <i>p</i> = .012 for <i>CYP2J2*7</i> and <i>CYP2C8*3</i>, respectively. <b>Conclusions:</b> Our results show, for the first time to our knowledge, that two SNPs in <i>CYP2C8</i> and <i>CYP2J2</i>, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events.
DOI: 10.6084/m9.figshare.5492929
title: Supplementary Material for: Mortality and Cardiovascular Morbidity Associated with Haemoglobin Levels: A Pooled Analysis of Randomised Controlled Trials

description: <b><i>Background/Aims:</i></b> Several randomised controlled trials (RCTs) have raised concerns about potential harm associated with erythropoiesis-stimulating agents (ESAs) in chronic kidney disease patients, especially when haemoglobin (Hb) levels above 13 g/dl were targeted. We report the relationship between Hb levels and outcomes in the methoxy polyethylene glycol-epoetin beta RCT programme. <b><i>Methods:</i></b> We assessed the association between Hb and a composite end point, as well as its components [all-cause mortality, myocardial infarction (MI) or cerebrovascular events (CVE)], in multiple post hoc analyses of 9 prospective RCTs (3,405 chronic kidney disease patients). Mean Hb levels over time and deviation from target were analysed using a Cox regression model. Time-adjusted average Hb, deviation from target, the last Hb, Hb slope and within-patient Hb variability preceding an event were analysed using a time-dependent Cox model. Hazard ratios and 95% confidence intervals were calculated. <b><i>Results:</i></b> Average Hb &lt;10 g/dl, decrease from stable baseline Hb &gt;1 g/dl, last Hb &lt;10 g/dl, Hb decline &gt;1.5 g/dl/4 weeks and increased Hb variability were associated with a higher risk of the composite end point and all-cause mortality. An increased risk for CVE and MI was found with a last Hb &lt;10 g/dl and with a decrease from baseline &gt;1 g/dl in the preceding month. <b><i>Conclusion:</i></b> In multiple analyses from a large programme of prospective clinical trials of ESA treatment, risk of all-cause mortality and cardiovascular morbidity risk was consistently higher at Hb &lt;10 g/dl and in patients whose Hb fell below target.
DOI: 10.6084/m9.figshare.5492950.v2
title: Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients

description: <b>Objective:</b> Arachidonic acid metabolism by cytochrome P450 (CYP) epoxygenases leads to epoxyeicosatrienoic acids (EETs), which are eicosanoids with vasodilator and anti-inflammatory properties. We aim to determine whether genetic variability in these routes may contribute to cardiovascular (CV) risk in renal transplant recipients. <b>Methods:</b> In a cohort of 355 patients, we determined the presence of two polymorphisms, <i>CYP2C8*3</i> and <i>CYP2J2*7</i>, known to affect eicosanoid levels. Associations with CV mortality, CV event-free long-term survival and graft survival were retrospectively investigated by logistic regression models. <b>Results:</b><i>CYP2J2*7</i> showed a statistical trend towards higher CV mortality (<i>p</i> = .06) and lower cardiac or cerebral event-free long-term survival (<i>p</i> = .05), whilst <i>CYP2C8*3</i> displayed a significant inverse association with the risk of CV event (hazard ratio [HR] = 0.34 [0.15–0.78], <i>p</i> = .01). The association of <i>CYP2J2*7</i> with CV mortality became significant when the analysis was restrained to 316 patients without a history of CV events prior to transplantation (HR = 15.72 [2.83–91.94], <i>p</i> = .005). In this subgroup of patients both single nucleotide polymorphisms (SNPs) were significantly associated with event-free survival. HR values were 5.44 (1.60–18.51), <i>p</i> = .007 and 0.26 (0.09–0.75), <i>p</i> = .012 for <i>CYP2J2*7</i> and <i>CYP2C8*3</i>, respectively. <b>Conclusions:</b> Our results show, for the first time to our knowledge, that two SNPs in <i>CYP2C8</i> and <i>CYP2J2</i>, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events.
DOI: 10.6084/m9.figshare.5492875
title: Preferred Communication Channels, 2017

description: Questionnaire and anonymised raw data for the Springer Nature Preferred Communication Channels Survey carried out in 2017.
DOI: 10.6084/m9.figshare.5492848
title: Supplementary Material for: Treatment with Haemodiafiltration Stabilises Vascular Stiffness (Measured by Aortic Pulse Wave Velocity) Compared to Haemodialysis

description: <b><i>Background/Aims:</i></b> Cerebrovascular diseases such as stroke are increased in dialysis patients, and haemodiafiltration has been reported to reduce cerebrovascular mortality compared to haemodialysis. We wished to determine whether haemodiafiltration improves arterial stiffness. <b><i>Methods:</i></b> We audited aortic pulse wave velocity (PWV) measurements 6 months apart in 3 cohorts of patients: 69 treated with haemodialysis, 78 who converted from haemodialysis to haemodiafiltration and 142 treated with haemodiafiltration. <b><i>Results:</i></b> Cohorts were well matched for age (means ± SD: haemodialysis 64 ± 15 years vs. haemodialysis to haemodiafiltration 64 ± 17 years vs. haemodiafiltration 67 ± 16 years), sex (male 65 vs. 59 vs. 63%), diabetes (45 vs. 56.4 vs. 44%) and body mass index (26 ± 6 vs. 26 ± 5 vs. 26 ± 5), respectively. Systolic blood pressure did not differ over time (haemodialysis 143 ± 25 vs. 146 ± 27 mm Hg, haemodialysis to haemodiafiltration 153 ± 26 vs. 154 ± 25 mm Hg, haemodiafiltration 149 ± 31 vs. 148 ± 30 mm Hg) or between groups. Aortic PWV significantly increased in the haemodialysis group (9.5 ± 1.9 vs. 10.2 ± 2.2 m/s, p &lt; 0.01) and haemodialysis to haemodiafiltration group (9.4 ± 1.9 vs. 10.1 ± 2.2 m/s, p &lt; 0.01), but did not change with haemodiafiltration (9.9 ± 2.1 vs. 10.1 ± 2.2 m/s). <b><i>Conclusions:</i></b> Aortic PWV, a measure of vascular stiffness, stabilised with haemodiafiltration. Our preliminary findings require further investigation to determine how haemodiafiltration may potentially improve vascular stiffness.
DOI: 10.6084/m9.figshare.5492950.v1
title: Polymorphisms in genes involved in vasoactive eicosanoids synthesis affect cardiovascular risk in renal transplant recipients

description: <b>Objective:</b> Arachidonic acid metabolism by cytochrome P450 (CYP) epoxygenases lead to epoxyeicosatrienoic acids (EETs), which eicosanoids with vasodilator and anti-inflammatory properties. We aim to determine whether genetic variability in these routes may contribute to cardiovascular (CV) risk in renal transplant recipients. <b>Methods:</b> In a cohort of 355 patients, we determined the presence of two polymorphisms, <i>CYP2C8*3</i> and <i>CYP2J2*7</i>, known to affect eicosanoids levels. Associations with CV mortality, CV event-free long-term survival and graft survival were retrospectively investigated by logistic regression models. <b>Results:</b><i>CYP2J2*7</i> showed a statistical trend towards higher CV mortality (p = 0.06) and lower cardiac or cerebral event-free long-term survival (p = 0.05), whilst <i>CYP2C8*3</i> displayed a significant inverse association with the risk of CV event [HR = 0.34 (0.15-0.78), p = 0.01]. The association of <i>CYP2J2*7</i> with CV mortality became significant when the analysis was restrained to 316 patients without a history of CV events prior to transplantation [Hazard ratio (HR)=15.72 (2.83-91.94), p = 0.005]. In this subgroup of patients both SNPs were significantly associated with event-free survival. HR values were 5.44 (1.60-18.51), p = 0.007 and 0.26 (0.09-0.75), p = 0.012 for <i>CYP2J2*7</i> and <i>CYP2C8*3</i>, respectively. <b>Conclusions:</b> Our results show, for the first time to our knowledge, that two SNPs in <i>CYP2C8</i> and <i>CYP2J2</i>, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events.
DOI: 10.6084/m9.figshare.5492812
title: Supplementary Material for: Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

description: <b><i>Background:</i></b> Heat shock proteins (HSPs) are expressed by cells in response to various environmental stresses. A single-nucleotide polymorphism A+1267G of the <i>HSPA1B</i> gene affects the expression of HSP70-2, with the A allele being protective against inflammatory conditions. We investigated the relation between the HSP A+1267G polymorphism and the clinical outcomes of Chinese peritoneal dialysis (PD) patients. <b><i>Methods:</i></b> We studied 347 new PD cases (181 males, age 56.6 ± 13.7 years). Genotyping was done by standard methods. Patients were followed for 40.5 ± 20.7 months for survival analysis. <b><i>Results:</i></b> For the entire cohort, there was no difference in the 5-year survival between genotype groups. However, there was a significant interaction between HSP polymorphism and diabetic status on the cardiovascular event-free survival. In patients without pre-existing diabetes, 5-year cardiovascular event-free survival of the GG/AG genotype group was significantly better than that of the AA genotype group (57.2 vs. 32.1%, p = 0.011). <b><i>Conclusion:</i></b> The G allele of the HSP70-2 A+1267G polymorphism confers survival advantages in non-diabetic PD patients. The role of HSP in the pathogenesis of cardiovascular disease in renal failure patients needs further investigation.
DOI: 10.6084/m9.figshare.5492839
title: Supplementary Material for: Effect of Nocturnal Haemodialysis on Body Composition

description: <b><i>Background:</i></b> Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. <b><i>Methods:</i></b> Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. <b><i>Results:</i></b> At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. <b><i>Conclusions:</i></b> One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD.
DOI: 10.6084/m9.figshare.5492875.v1
title: Preferred Communication Channels, 2017

description: Questionnaire and anonymised raw data for the Springer Nature Preferred Communication Channels Survey carried out in 2017.
DOI: 10.6084/m9.figshare.5492782
title: Supplementary Material for: Is the Systemic Microvascular Endothelial Glycocalyx in Peritoneal Dialysis Patients Related to Peritoneal Transport?

description: <b><i>Background/Aims:</i></b> The capillary wall coated by the endothelial glycocalyx is the main transport barrier during peritoneal dialysis (PD). Here, we investigated the relationships between measurements of the systemic endothelial glycocalyx and peritoneal transport in PD patients. <b><i>Methods:</i></b> We performed sidestream darkfield (SDF) imaging of the sublingual microvasculature in 15 patients, measured the perfused boundary region (PBR), which includes the permeable part of the glycocalyx, and calculated the estimated blood vessel density (EBVD). All patients underwent a peritoneal permeability analysis. <b><i>Results:</i></b> No relationships were present between the imaging and peritoneal transport parameters, neither in the group as a whole nor in fast transporters. In patients with nonfast peritoneal transport status, PBR had a negative relationship with EBVD and small solute transport, and a positive one with net ultrafiltration (NUF). The EBVD showed a positive correlation with glucose absorption and a negative one with NUF. We found no relationships with the peritoneal transport of albumin. <b><i>Conclusions:</i></b> No relationships are present between the systemic endothelial glycocalyx, which was assessed by SDF, and peritoneal transport. In nonfast transporters, a reduction in blood vessel density caused by endothelial glycocalyx alterations or a thicker permeable phase of the glycocalyx delaying the access of small solutes to the small pores may be important.
DOI: 10.6084/m9.figshare.5492812.v1
title: Supplementary Material for: Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

description: <b><i>Background:</i></b> Heat shock proteins (HSPs) are expressed by cells in response to various environmental stresses. A single-nucleotide polymorphism A+1267G of the <i>HSPA1B</i> gene affects the expression of HSP70-2, with the A allele being protective against inflammatory conditions. We investigated the relation between the HSP A+1267G polymorphism and the clinical outcomes of Chinese peritoneal dialysis (PD) patients. <b><i>Methods:</i></b> We studied 347 new PD cases (181 males, age 56.6 ± 13.7 years). Genotyping was done by standard methods. Patients were followed for 40.5 ± 20.7 months for survival analysis. <b><i>Results:</i></b> For the entire cohort, there was no difference in the 5-year survival between genotype groups. However, there was a significant interaction between HSP polymorphism and diabetic status on the cardiovascular event-free survival. In patients without pre-existing diabetes, 5-year cardiovascular event-free survival of the GG/AG genotype group was significantly better than that of the AA genotype group (57.2 vs. 32.1%, p = 0.011). <b><i>Conclusion:</i></b> The G allele of the HSP70-2 A+1267G polymorphism confers survival advantages in non-diabetic PD patients. The role of HSP in the pathogenesis of cardiovascular disease in renal failure patients needs further investigation.