cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30017534.v1
title: Pseudohypoxia induced by iron chelator activates tumor immune response in lung cancer

description: Hypoxia-inducible factor (HIF) signaling plays a critical role in immune cell function. Pseudohypoxia is characterized as iron-mediated stabilization of HIF-1α under normoxic conditions, which can be induced by iron chelators. This study explored whether iron chelators exert antitumor effects by enhancing tumor immune responses and elucidating the underlying mechanisms. The iron chelators Super–polyphenol 10 (SP10) and Deferoxamine (DFO) were used to create iron-deficient and pseudohypoxia conditions. Pseudohypoxia induced by iron chelators stimulates IL-2 secretion from T cells and from both human and murine nonsmall cell lung cancer (NSCLC) cell lines (A549, PC-3, and LLC). Administration of SP10 reduced tumor growth when LLC tumors were implanted in C57BL/6 mice; however, this was not observed in immunodeficient RAG1-deficient C57BL/6 mice. SP10 itself did not directly inhibit LLC cells proliferation <i>in vitro</i>, suggesting an activation of the tumor immune response. SP10 synergistically enhanced the efficacy of PD-1 antibody therapy in lung cancer by increasing the number of tumor-infiltrating lymphocytes (TILs). In conclusion, iron chelation-induced pseudohypoxia activates tumor immune responses by directly upregulating HIF-1α, augmenting T cell function, and inducing IL-2 secretion from T cells, and cancer cells, thereby amplifying the immune efficacy of the PD-1 antibody in lung cancer treatment.
DOI: 10.6084/m9.figshare.30017536.v1
title: Far-infrared radiation-mediated GPx-1/eNOS/ERK signaling contributes to the protective potential against methamphetamine-caused impairments in recognition memory in mice

description: Far-infrared radiation (FIR) induces glutathione peroxidase-1 (GPx-1) expression and enhances microcirculation by upregulating endothelial nitric oxide synthase (eNOS). However, the role of eNOS in FIR-mediated neuroprotection remains unclear. Here, we investigated whether FIR upregulates eNOS and extracellular signal-regulated kinase (ERK) signaling to mitigate recognition memory impairment caused by methamphetamine (MA). FIR significantly reduced MA-induced oxidative stress, which was primarily associated with GPx-1 inhibition. FIR or genetic overexpression of GPx-1 (GPx-1 TG) in mice significantly attenuated the MA-induced reduction in phospho-eNOS (p-eNOS) and phospho-ERK (p-ERK). Triple-label immunostaining revealed colocalization of p-eNOS, p-ERK, and GPx-1 within the same cellular populations in the prefrontal cortex. In non-transgenic (non-TG) mice, FIR exposure improved MA-induced cholinergic and memory deficits. However, FIR did not provide additional cognitive benefits in GPx-1 TG mice, and the GPx-1 inhibitor mercaptosuccinate blocked FIR-mediated cholinergic effects. Inhibitors of eNOS (i.e. L-NAME) and ERK (i.e. U0126) also significantly blocked the FIR-driven memory-enhancing effects in non-TG mice. Unlike L-NAME, which inhibits phosphorylation of both eNOS and ERK, U0126 did not affect FIR-induced eNOS phosphorylation, suggesting that eNOS is an upstream molecule for ERK signaling. Our finding suggests that GPx-1 is an essential mediator of FIR-induced memory enhancement, and that FIR exposure attenuates MA-induced cognitive impairments <i>via</i> cholinergic upregulation associated with GPx-1/eNOS/ERK signaling.
DOI: 10.6084/m9.figshare.30187461.v2
title: Betulinic acid protects sH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis

description: Betulinic acid (BA) is a pentacyclic triterpenoid with broad pharmacological potential and widely recognized for its neuroprotective effects. This study investigated the potential protective effects of this compound on <i>in vitro</i> differentiated human neuroblastoma SH-SY5Y cells against LPS and FeSO<sub>4</sub>-induced ferroptosis, apoptosis, neuroinflammation, and dopaminergic cell death, and explored the underlying mechanisms. Differentiated human neuroblastoma SH-SY5Y cells were exposed to LPS and FeSO<sub>4</sub>, and the cellular viability was evaluated using the MTT assay. Flow cytometry was performed to assess apoptotic cell death. Additionally, the expression levels of key markers associated with ferroptosis, apoptosis, and other relevant signaling proteins were analyzed through western blotting and Immunocytochemical staining techniques. However, co<b>-</b>exposure with LPS and FeSO<sub>4</sub> resulted in a dose-dependent reduction in cell viability, which was significantly reversed by pretreatment with BA (0.3-30μM). Exposure to LPS and FeSO<sub>4</sub> increased the DMT1, Bax, caspase-3, and alpha-synuclein, and decreased the GPX4, FTH1, SLC7A11, Nrf2, Keap1, HO-1, PARK7, Bcl-2, NeuN, and TH levels, resulting in cell ferroptosis, apoptosis, and dopaminergic cell death. Furthermore, LPS and FeSO<sub>4</sub> significantly increased the expression of IL-6, TNF-α, and phosphorylation of p38, pMAPK, and pNFkB in the cells. Pretreatment with BA markedly suppressed LPS and FeSO<sub>4</sub>-induced upregulation of pro-inflammatory cytokines, ferroptosis, apoptosis, and dopaminergic cell death markers. These findings suggest that BA exerts neuroprotection by modulating the GPX4/Nrf2/Keap-1/HO-1 antioxidant defense and p38MAPK/NF-κB inflammatory signaling pathways, highlighting its potential as a therapeutic agent for oxidative stress-related neurodegenerative conditions, such as Parkinson’s disease (PD). BA protected SH-SY5Y cells against LPS and FeSO<sub>4</sub>-induced ferroptosis, apoptosis, and neurotoxicity.BA inhibited LPS and FeSO<sub>4</sub>-induced cell death and inflammatory signaling via suppression of IL-6, TNF-α, and p38MAPK/NF-κB/Nrf2/Keap-1/HO-1 signaling.BA may be a promising neuroprotective agent for therapeutic targeting of neuroinflammation and iron-induced neurodegeneration, like PD. BA protected SH-SY5Y cells against LPS and FeSO<sub>4</sub>-induced ferroptosis, apoptosis, and neurotoxicity. BA inhibited LPS and FeSO<sub>4</sub>-induced cell death and inflammatory signaling via suppression of IL-6, TNF-α, and p38MAPK/NF-κB/Nrf2/Keap-1/HO-1 signaling. BA may be a promising neuroprotective agent for therapeutic targeting of neuroinflammation and iron-induced neurodegeneration, like PD.
DOI: 10.15468/dl.fg8r72
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tinamiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-10 -40,0 -40,0 -30,-10 -30,-10 -40))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017784-251009101135966/datasets/export for details.
DOI: 10.48579/pro/bsvtil
title: Replication Data for Fig 5.3, Top, BGUW, Fleas per adult in March or April, 13 Oct 2025

description: FILE DESCRIPTION Keywords: BGUW, fleas per adult, March-April Figure 5.3, Top, Number of fleas per adult in February, March, or April. See Fig 5.3, Middle, for number of fleas per adult in May or June. The number above each SE line indicates the number of individuals for which my students and I counted fleas during the process of handling and marking. See figures 3.5 and 3.6 for intersexual differences in flea-counts for adults and juveniles. B = BTPDs = black-tailed prairie dogs. W = WTPDs = white-tailed prairie dogs G = GPDs = Gunnison's prairie dogs U = UPDs = Utah prairie dogs BGUW = black-tails, gunnisons, utahs, and white-tails Numbers shown here are means plus one standard error (SEM). Note: these data are summaries only. Most of the raw data are in EXCEL file = BGUW, Final flea and body masses, 14 Jan 2025. Note: Flea counts from adults in this file are from TWO time periods: March-April and May-June Note: Flea counts for juveniles are at first juvenile emergence = May -June I used only one flea-count per adult prairie dog per time period.
DOI: 10.15468/dl.s5mgzx
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Casuariiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-30 -80,-20 -80,-20 -70,-30 -70,-30 -80))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017786-251009101135966/datasets/export for details.
DOI: 10.15468/dl.9d5p36
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Hebe recurva)"
 ]
}

 The dataset includes 10 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017785-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b26h6t
title: Occurrence Download

description: A dataset containing 191407 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Festuca arundinacea, Festuca arundinacea, Festuca arundinacea)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 191407 records from 1098 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017766-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bwg476
title: Occurrence Download

description: A dataset containing 15087 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Ursus arctos Linnaeus, 1758",
 "Country is Norway",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 15087 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017788-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.csfw6g
title: Occurrence Download

description: A dataset containing 15609 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Lutra lutra (Linnaeus, 1758)",
 "Country is Norway",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 15609 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017789-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zjcvdu
title: Occurrence Download

description: A dataset containing 12161 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Canis lupus Linnaeus, 1758",
 "Country is Norway",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 12161 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017787-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17122287
title: Bias-corrected remote sensing surface chlorophyll-a concentration datasets

description: Merged remote sensing chlorophyll-a (chl-a) concentration datasets available online often suffer from temporal inconsistencies, which limit their suitability for robust analyses of long-term changes under climate change. This repository provides eight bias-corrected versions of four widely used chlorophyll-a datasets: OC-CCI v6.0, GlobColour-AVW, GlobColour-CMEMS, and Yu2023. A full description of the datasets and the correction procedures is provided in our paper "North-South asymmetry in subtropical phytoplankton response to recent warming".

Two types of correction methods are applied:





TGDM: spatio-temporal inconsistencies corrected using the Temporal Gap Detection Method (van Oostende et al., 2022).




FILL: inconsistencies corrected through statistical gap filling.



 

Characteristics of the datasets :



Regular grid with a 1° resolution

Time resolution : monthly

Period : 1998-2023


 

References :

van Oostende, M., Hieronymi, M., Krasemann, H., Baschek, B. & Röttgers, R. Correction of inter-mission inconsistencies in merged ocean colour satellite data. Front. Remote Sens. 3, (2022).
DOI: 10.15468/dl.8x5q8x
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Casuariiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-40 -80,-30 -80,-30 -70,-40 -70,-40 -80))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017790-251009101135966/datasets/export for details.
DOI: 10.15468/dl.3vn29v
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tinamiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((0 -40,10 -40,10 -30,0 -30,0 -40))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017792-251009101135966/datasets/export for details.
DOI: 10.15468/dl.wacdcu
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Casuariiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-50 -80,-40 -80,-40 -70,-50 -70,-50 -80))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017791-251009101135966/datasets/export for details.
DOI: 10.15468/dl.m28nf8
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tinamiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((10 -40,20 -40,20 -30,10 -30,10 -40))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017793-251009101135966/datasets/export for details.
DOI: 10.15468/dl.gsr9wk
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Octolasion lacteum",
 "Country is South Africa",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017794-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.27mrce
title: Occurrence Download

description: A dataset containing 25 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Octolasion lacteum",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 25 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017795-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30353269
title: Data Files

description: This study examines the fidelity of datasets generated by generative AI (GenAI) tools in comparison to real-world survey data, addressing methodological implications for computational social science. Using an original survey as a benchmark, we created three datasets: authentic respondent data, GenAI-simulated datasets produced through programmed distributional prompts, and GenAI-reconstructed datasets designed to replicate plausible human responses. Both artificial datasets were generated using large language models, specifically ChatGPT and Perplexity. Comparative analyses focused on distributional accuracy, reliability, and hypothesis-testing validity. Findings show that GenAI-simulated datasets approximated statistical distributions but lacked natural response heterogeneity, whereas GenAI-reconstructed datasets captured contextual patterns and nuanced correlations but diverged from exact statistical parameters. These results highlight the distinct yet complementary roles of AI-driven simulation and reconstruction for replication and robustness testing. The study contributes to discussions on reproducibility, credibility, and ethical integration of GenAI in high-impact social science research.
DOI: 10.6084/m9.figshare.30353269.v2
title: Data Files

description: This study examines the fidelity of datasets generated by generative AI (GenAI) tools in comparison to real-world survey data, addressing methodological implications for computational social science. Using an original survey as a benchmark, we created three datasets: authentic respondent data, GenAI-simulated datasets produced through programmed distributional prompts, and GenAI-reconstructed datasets designed to replicate plausible human responses. Both artificial datasets were generated using large language models, specifically ChatGPT and Perplexity. Comparative analyses focused on distributional accuracy, reliability, and hypothesis-testing validity. Findings show that GenAI-simulated datasets approximated statistical distributions but lacked natural response heterogeneity, whereas GenAI-reconstructed datasets captured contextual patterns and nuanced correlations but diverged from exact statistical parameters. These results highlight the distinct yet complementary roles of AI-driven simulation and reconstruction for replication and robustness testing. The study contributes to discussions on reproducibility, credibility, and ethical integration of GenAI in high-impact social science research.
DOI: 10.6084/m9.figshare.30353269.v1
title: Data Files

description: This study examines the fidelity of datasets generated by generative AI (GenAI) tools in comparison to real-world survey data, addressing methodological implications for computational social science. Using an original survey as a benchmark, we created three datasets: authentic respondent data, GenAI-simulated datasets produced through programmed distributional prompts, and GenAI-reconstructed datasets designed to replicate plausible human responses. Both artificial datasets were generated using large language models, specifically ChatGPT and Perplexity. Comparative analyses focused on distributional accuracy, reliability, and hypothesis-testing validity. Findings show that GenAI-simulated datasets approximated statistical distributions but lacked natural response heterogeneity, whereas GenAI-reconstructed datasets captured contextual patterns and nuanced correlations but diverged from exact statistical parameters. These results highlight the distinct yet complementary roles of AI-driven simulation and reconstruction for replication and robustness testing. The study contributes to discussions on reproducibility, credibility, and ethical integration of GenAI in high-impact social science research.
DOI: 10.15468/dl.m24bzg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Tinamiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((20 -40,30 -40,30 -30,20 -30,20 -40))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017796-251009101135966/datasets/export for details.
DOI: 10.34961/5666
title: Data set for paper titled: Teacher competencies in health education: results of a Delphi study

description: n/a THE LINK TO THE ARTICLE FOR THIS DATA SET IS: http://hdl.handle.net/10344/4774
description: This is the data set for the article titled “Teacher competencies in Health Education: Results of a Delphi Study”. Published online in PLOS ONE. The data was collected in the 2011/2012 academic year. Three files are included, the raw data file from Round 2 and Round 3 and a file which contains the codes used for the data.
DOI: 10.34961/5667
title: Data set for paper titled: Psychological distress and coping amongst higher education students: A mixed method enquiry.

description: THE LINK TO THE ARTICLE FOR THIS DATA SET IS: http://hdl.handle.net/10344/4205
description: This is the data set for the article titled “Psychological distress and coping amongst higher education students: A mixed method enquiry”. Published online in PLOS ONE. The data was collected in the 2010/2011 academic year. Two files are included, the raw data file and a file which contains the codes used for the data.
DOI: 10.15468/dl.tc5a8w
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Casuariiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-60 -80,-50 -80,-50 -70,-60 -70,-60 -80))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017797-251009101135966/datasets/export for details.
DOI: 10.15468/dl.9y6utp
title: Occurrence Download

description: A dataset containing 605 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Hebe salicifolia)"
 ]
}

 The dataset includes 605 records from 57 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017798-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u6s2ex
title: Occurrence Download

description: A dataset containing 870 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DecimalLatitude is -25.8305701305094,-25.8042452661002",
 "DecimalLongitude is 28.3772297545805,28.4034844627699"
 ]
}

 The dataset includes 870 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017799-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.