cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13089482
title: Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours

description: Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, although there is little direct evidence to support this claim. Here we utilized a series of isogenic cisplatin-resistant cell models and observed a strong association between cisplatin resistance in TGCT cells and a net increase in global CpG and non-CpG DNA methylation spanning regulatory, intergenic, genic and repeat elements. Hypermethylated loci were significantly enriched for repressive DNA segments, CTCF and RAD21 sites and lamina associated domains, suggesting that global nuclear reorganization of chromatin structure occurred in resistant cells. Hypomethylated CpG loci were significantly enriched for EZH2 and SUZ12 binding and H3K27me3 sites. Integrative transcriptome and methylome analyses showed a strong negative correlation between gene promoter and CpG island methylation and gene expression in resistant cells and a weaker positive correlation between gene body methylation and gene expression. A bidirectional shift between gene promoter and gene body DNA methylation occurred within multiple genes that was associated with upregulation of polycomb targets and downregulation of tumour suppressor genes. These data support the hypothesis that global remodelling of DNA methylation is a key factor in mediating cisplatin hypersensitivity and chemoresistance of TGCTs and furthers the rationale for hypomethylation therapy for refractory TGCT patients.
DOI: 10.6084/m9.figshare.13612445.v1
title: Additional file 7 of The semi-dwarfing gene Rht-dp from dwarf polish wheat (Triticum polonicum L.) is the "Green Revolution” gene Rht-B1b

description: Additional file 7: Table S5. The information of Dwarfism-related DEGs induced by DELLA mutant Rht-dp.
DOI: 10.6084/m9.figshare.13612475.v1
title: Additional file 2 of Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

description: Additional file 2: Table S1. List of genes showing increased intron retention upon Rbm10 overexpression.
DOI: 10.6084/m9.figshare.13612478
title: Additional file 3 of Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

description: Additional file 3: Table S2. List of genes showing decreased intron retention upon Rbm10 overexpression.
DOI: 10.6084/m9.figshare.13612478.v1
title: Additional file 3 of Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

description: Additional file 3: Table S2. List of genes showing decreased intron retention upon Rbm10 overexpression.
DOI: 10.6084/m9.figshare.13089482.v2
title: Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours

description: Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, although there is little direct evidence to support this claim. Here we utilized a series of isogenic cisplatin-resistant cell models and observed a strong association between cisplatin resistance in TGCT cells and a net increase in global CpG and non-CpG DNA methylation spanning regulatory, intergenic, genic and repeat elements. Hypermethylated loci were significantly enriched for repressive DNA segments, CTCF and RAD21 sites and lamina associated domains, suggesting that global nuclear reorganization of chromatin structure occurred in resistant cells. Hypomethylated CpG loci were significantly enriched for EZH2 and SUZ12 binding and H3K27me3 sites. Integrative transcriptome and methylome analyses showed a strong negative correlation between gene promoter and CpG island methylation and gene expression in resistant cells and a weaker positive correlation between gene body methylation and gene expression. A bidirectional shift between gene promoter and gene body DNA methylation occurred within multiple genes that was associated with upregulation of polycomb targets and downregulation of tumour suppressor genes. These data support the hypothesis that global remodelling of DNA methylation is a key factor in mediating cisplatin hypersensitivity and chemoresistance of TGCTs and furthers the rationale for hypomethylation therapy for refractory TGCT patients.
DOI: 10.6084/m9.figshare.13612679.v1
title: Additional file 11 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 11: Table S11. KEGG pathways of downregulated miRNA targets
DOI: 10.6084/m9.figshare.13612685.v1
title: Additional file 2 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 2: Table S2. DE-miRNAs
DOI: 10.6084/m9.figshare.13612688
title: Additional file 3 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 3: Table S3. miRNAs of profile 4
DOI: 10.6084/m9.figshare.13612691
title: Additional file 4 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 4: Table S4. miRNAs of profile 21
DOI: 10.6084/m9.figshare.13612697
title: Additional file 6 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 6: Table S6. Interaction between upregulated miRNAs and downregulated genes
DOI: 10.6084/m9.figshare.13612700.v1
title: Additional file 7 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 7: Table S7. GO terms of upregulated miRNA targets
DOI: 10.6084/m9.figshare.13612706
title: Additional file 8 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 8: Table S8. KEGG pathways of upregulated miRNA targets
DOI: 10.6084/m9.figshare.13612706.v1
title: Additional file 8 of Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

description: Additional file 8: Table S8. KEGG pathways of upregulated miRNA targets
DOI: 10.6084/m9.figshare.13089482.v3
title: Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours

description: Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, although there is little direct evidence to support this claim. Here we utilized a series of isogenic cisplatin-resistant cell models and observed a strong association between cisplatin resistance in TGCT cells and a net increase in global CpG and non-CpG DNA methylation spanning regulatory, intergenic, genic and repeat elements. Hypermethylated loci were significantly enriched for repressive DNA segments, CTCF and RAD21 sites and lamina associated domains, suggesting that global nuclear reorganization of chromatin structure occurred in resistant cells. Hypomethylated CpG loci were significantly enriched for EZH2 and SUZ12 binding and H3K27me3 sites. Integrative transcriptome and methylome analyses showed a strong negative correlation between gene promoter and CpG island methylation and gene expression in resistant cells and a weaker positive correlation between gene body methylation and gene expression. A bidirectional shift between gene promoter and gene body DNA methylation occurred within multiple genes that was associated with upregulation of polycomb targets and downregulation of tumour suppressor genes. These data support the hypothesis that global remodelling of DNA methylation is a key factor in mediating cisplatin hypersensitivity and chemoresistance of TGCTs and furthers the rationale for hypomethylation therapy for refractory TGCT patients.
DOI: 10.6084/m9.figshare.13089482.v1
title: Hypermethylation and global remodeling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumors

description: Testicular germ cell tumors (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift toward DNA hypermethylation mediates cisplatin resistance in TGCT cells, although there is little direct evidence to support this claim. Here we utilized a series of isogenic cisplatin resistant cell models and observed a strong association between cisplatin resistance in TGCT cells and a net increase in global CpG and non-CpG DNA methylation spanning regulatory, intergenic, genic and repeat elements. Hypermethylated loci were significantly enriched for repressive DNA segments, CTCF and RAD21 sites and lamina associated domains, suggesting that global nuclear reorganization of chromatin structure occurred in resistant cells. Hypomethylated CpG loci were significantly enriched for EZH2 and SUZ12 binding and H3K27me3 sites. Integrative transcriptome and methylome analyses showed a strong negative correlation between gene promoter and CpG island methylation and gene expression in resistant cells and a weaker positive correlation between gene body methylation and gene expression. A bidirectional shift between gene promoter and gene body DNA methylation occurred within multiple genes that was associated with upregulation of polycomb targets and downregulation of tumor suppressor genes. These data support the hypothesis that global remodeling of DNA methylation is a key factor in mediating cisplatin hypersensitivity and chemoresistance of TGCTs and furthers the rationale for hypomethylation therapy for refractory TGCT patients.
DOI: 10.48597/qx9r-48fu
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/r42n-grr3
title: Measurement of Precipitation_amount at Aspvreten

description: Measurement of Precipitation_amount at Aspvreten
DOI: 10.48597/rs4f-755u
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/rxwd-f2g9
title: Measurement of Precipitation_amount at Gårdsjön

description: Measurement of Precipitation_amount at Gårdsjön
DOI: 10.48597/srqs-qsh7
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/sthz-wuja
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/syky-r37w
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/tg34-akx7
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/tq3n-2q7w
title: Measurement of Propanone at Waldhof

description: Measurement of Propanone at Waldhof
DOI: 10.48597/ubbz-24su
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/upkr-ttyg
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/v38x-u5sq
title: Measurement of Heavy metals at Banchory

description: Measurement of Heavy metals at Banchory
DOI: 10.48597/vheq-m3ky
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/vs8r-uahg
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/w72q-qkf6
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/w8gg-6xy3
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/wjys-b86m
title: Measurement of Heavy metals at Gårdsjön

description: Measurement of Heavy metals at Gårdsjön
DOI: 10.48597/wkun-9hph
title: Measurement of Precipitation_amount at Aspvreten

description: Measurement of Precipitation_amount at Aspvreten
DOI: 10.48597/wunk-ryqs
title: Measurement of Precipitation_amount at Bredkälen

description: Measurement of Precipitation_amount at Bredkälen
DOI: 10.48597/wv37-zavh
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/x4qt-g7ab
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/x9gb-a7by
title: Measurement of Propanone at Waldhof

description: Measurement of Propanone at Waldhof
DOI: 10.48597/xskp-g3pu
title: Measurement of Cobalt at Gårdsjön

description: Measurement of Cobalt at Gårdsjön
DOI: 10.48597/xwnc-6k2w
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/y3xs-4dkv
title: Measurement of Precipitation_amount at Lista

description: Measurement of Precipitation_amount at Lista
DOI: 10.48597/ywzj-zzqn
title: Measurement of Precipitation_amount at Gårdsjön

description: Measurement of Precipitation_amount at Gårdsjön
DOI: 10.48597/yxug-8ejq
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/z76d-y687
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/zzur-kans
title: Measurement of Inorganics in precipitation at Birkenes

description: Measurement of Inorganics in precipitation at Birkenes
DOI: 10.48597/22mw-qw8q
title: Measurement of pH at Chopok

description: Measurement of pH at Chopok
DOI: 10.48597/2q9q-kcc6
title: Measurement of Nitrate at Chopok

description: Measurement of Nitrate at Chopok
DOI: 10.48597/2qfj-sh8e
title: Measurement of Precipitation_amount at Eskdalemuir

description: Measurement of Precipitation_amount at Eskdalemuir
DOI: 10.48597/3534-4x5f
title: Measurement of pH at Amberd

description: Measurement of pH at Amberd
DOI: 10.48597/38qx-6qsx
title: Measurement of Calcium at Chopok

description: Measurement of Calcium at Chopok
DOI: 10.48597/3dun-5zd5
title: Measurement of Chromium at Villum Research Station, Station Nord

description: Measurement of Chromium at Villum Research Station, Station Nord
DOI: 10.48597/3f3y-b8mm
title: Measurement of pH at Stará Lesná

description: Measurement of pH at Stará Lesná
DOI: 10.48597/3nq2-88q2
title: Measurement of Sulphate_corrected at Starina

description: Measurement of Sulphate_corrected at Starina
DOI: 10.48597/4xt9-mw8n
title: Measurement of Sodium at Nuuk

description: Measurement of Sodium at Nuuk
DOI: 10.48597/52sj-nnb6
title: Measurement of Sulphate_corrected at Keldsnor

description: Measurement of Sulphate_corrected at Keldsnor
DOI: 10.15468/dl.snpz43
title: Occurrence Download

description: A dataset containing 110 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sporobolus welwitschii Rendle"
 ]
}

 The dataset includes 110 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112150-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5qzs6k
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sterculia spatulata Warb."
 ]
}

 The dataset includes 3 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112149-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jph653
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Clausena wampi (Blanco) Oliv."
 ]
}

 The dataset includes 24 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112151-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g4uvmk
title: Occurrence Download

description: A dataset containing 20 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sonerila minima Stapf ex Ridl."
 ]
}

 The dataset includes 20 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112153-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h8m7jq
title: Occurrence Download

description: A dataset containing 110 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Solanum toliaraea D' Arcy & Rakot."
 ]
}

 The dataset includes 110 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112154-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9yz9mm
title: Occurrence Download

description: A dataset containing 469 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fortunearia sinensis Rehder & E.H.Wilson"
 ]
}

 The dataset includes 469 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112152-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ttefg4
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Strobilanthes muratae J.R.I.Wood"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112155-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kce2y6
title: Occurrence Download

description: A dataset listing the 1519 species recorded in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "PublishingCountry is United States of America"
 ]
}

 The dataset's 1519 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112106-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yg3kvp
title: Occurrence Download

description: A dataset containing 663 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Silene himalayensis (Rohrb.) Majumdar"
 ]
}

 The dataset includes 663 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112156-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nxm6hn
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sporoxeia blastifolia (Guillaumin) C.Hansen"
 ]
}

 The dataset includes 7 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112158-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.chya8m
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sterculia stenocarpa H.J.P.Winkl."
 ]
}

 The dataset includes 58 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112157-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pdnmyx
title: Occurrence Download

description: A dataset containing 3412104 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "OccurrenceStatus is Present",
 "Year is 2017"
 ]
}

 The dataset includes 3412104 records from 210 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112050-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s55tfn
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sonerila mollis Stapf & King"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112159-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6n7xme
title: Occurrence Download

description: A dataset containing 1583 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Solanum tomentosum L."
 ]
}

 The dataset includes 1583 records from 59 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112160-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d94knc
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Strobilanthes murutorum J.R.I.Wood"
 ]
}

 The dataset includes 6 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112161-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9m8y8h
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Silene hirticalyx Boiss. & Hausskn."
 ]
}

 The dataset includes 7 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112162-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s5pc7d
title: Occurrence Download

description: A dataset containing 35 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sterculia stigmarota Pierre"
 ]
}

 The dataset includes 35 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112164-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.