cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8142713
title: Additional file 2: of In silico genome-wide miRNA-QTL-SNPs analyses identify a functional SNP associated with mastitis in Holsteins

description: Table S1. SNPs within the bovine precursor, mature and seed sequences of microRNAs (.xlsx). (XLSX 429 kb)
DOI: 10.6084/m9.figshare.8142713.v1
title: Additional file 2: of In silico genome-wide miRNA-QTL-SNPs analyses identify a functional SNP associated with mastitis in Holsteins

description: Table S1. SNPs within the bovine precursor, mature and seed sequences of microRNAs (.xlsx). (XLSX 429 kb)
DOI: 10.6084/m9.figshare.8142722
title: Additional file 3: of In silico genome-wide miRNA-QTL-SNPs analyses identify a functional SNP associated with mastitis in Holsteins

description: Table S2. Candidate miRNA-related SNPs located in the QTLs of 8 traits including CM, SCC, SCS, UDPTH, TLGTH, UCI, UHT and NEUT (8 sheets). (.xlsx). (XLSX 289 kb)
DOI: 10.6084/m9.figshare.8142722.v1
title: Additional file 3: of In silico genome-wide miRNA-QTL-SNPs analyses identify a functional SNP associated with mastitis in Holsteins

description: Table S2. Candidate miRNA-related SNPs located in the QTLs of 8 traits including CM, SCC, SCS, UDPTH, TLGTH, UCI, UHT and NEUT (8 sheets). (.xlsx). (XLSX 289 kb)
DOI: 10.25402/fon.19152773
title: Supplementary Table – Stratification of axillary lymph node metastasis risk with breast magnetic resonance imaging in breast cancer

description: <b>Supplementary
 Table</b> 1: Stratification of
 axillary lymph node metastasis risk with breast magnetic resonance imaging in
 breast cancer
 <i>Characteristics of
 training and validation group</i>
DOI: 10.25402/fon.19152773.v1
title: Supplementary Table – Stratification of axillary lymph node metastasis risk with breast magnetic resonance imaging in breast cancer

description: <b>Supplementary
 Table</b> 1: Stratification of
 axillary lymph node metastasis risk with breast magnetic resonance imaging in
 breast cancer
 <i>Characteristics of
 training and validation group</i>
DOI: 10.6084/m9.figshare.8142782
title: MOESM2 of Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas

description: Additional file 2: Table S2. Supplementary tables for the details of patient sample information from CGGA and TCGA.
DOI: 10.6084/m9.figshare.8142782.v1
title: MOESM2 of Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas

description: Additional file 2: Table S2. Supplementary tables for the details of patient sample information from CGGA and TCGA.
DOI: 10.6084/m9.figshare.7094243
title: U–Pb detrital zircon geochronology and Hf isotopic composition of Permian clastic rocks, Zhen’an basin, South Qinling belt: implications for the Paleozoic tectonic evolution of the Qinling orogenic belt

description: Detrital zircon U–Pb geochronology, and Hf isotope compositional data for Permian strata near Xikou, Zhen’an in the South Qinling belt help constrain the tectonic evolutionary history of the Qinling Orogenic Belt. Results show that detrital zircons recovered from three sandstone samples share similar age-probabilities, including four age groups comprising 2100–1760 Ma (55.8%), 2750–2300 Ma (16.1%), 1200–770 Ma (12.3%), and 512–256 Ma (10.1%). By comparison with potential source areas, we conclude that Permian detrital zircons mainly originated from the southern margin of the North China Block, and probably the North Qinling belt as well, while the northern margin of the Yangtze Block did not supply detrital sediment. This distribution implies the South Qinling belt lay adjacent to the North Qinling belt and the North China Block by the Permian, but was separated from the Yangtze Block by the Mianlue Ocean, and support the Late Triassic collision between the Yangtze and North China Blocks.
DOI: 10.6084/m9.figshare.7094243.v1
title: U–Pb detrital zircon geochronology and Hf isotopic composition of Permian clastic rocks, Zhen’an basin, South Qinling belt: implications for the Paleozoic tectonic evolution of the Qinling orogenic belt

description: Detrital zircon U–Pb geochronology, and Hf isotope compositional data for Permian strata near Xikou, Zhen’an in the South Qinling belt help constrain the tectonic evolutionary history of the Qinling Orogenic Belt. Results show that detrital zircons recovered from three sandstone samples share similar age-probabilities, including four age groups comprising 2100–1760 Ma (55.8%), 2750–2300 Ma (16.1%), 1200–770 Ma (12.3%), and 512–256 Ma (10.1%). By comparison with potential source areas, we conclude that Permian detrital zircons mainly originated from the southern margin of the North China Block, and probably the North Qinling belt as well, while the northern margin of the Yangtze Block did not supply detrital sediment. This distribution implies the South Qinling belt lay adjacent to the North Qinling belt and the North China Block by the Permian, but was separated from the Yangtze Block by the Mianlue Ocean, and support the Late Triassic collision between the Yangtze and North China Blocks.
DOI: 10.6084/m9.figshare.7094246
title: Early Cretaceous volcanic and sub-volcanic rocks in the Erlian Basin and adjacent areas, Northeast China: new geochemistry, geochronology and zircon Hf isotope constraints on petrogenesis and tectonic setting

description: Early Cretaceous volcanic rocks are widely distributed in northeast China and being extensively observed recently. However, petrogenesis and tectonic setting of these volcanic rocks are still on debate. We present zircon U–Pb ages, whole-rock geochemistry and zircon Hf isotope for these volcanic and sub-volcanic rocks surrounding the Erlian Basin including basic-intermediate volcanic rocks, intermediate-felsic volcanic rocks, and dacites and trachyandesite from dikes. The zircon U–Pb dating results indicate that these rocks formed in the Early Cretaceous (146–129 Ma). The basic-intermediate volcanic rocks mainly consist of basaltic andesite, which are featured by low SiO<sub>2</sub> concentrations (49.96–58.34 wt. %), high Mg<sup>#</sup> values (54–37) and Co contents (17.85–25.98 ppm), and positive <i>ε</i><sub>Hf(<i>t</i>)</sub> values (+7.11 to +13.87). Moreover, they show high La/Nb (1.79–2.87) and low La/Ba (0.02–0.08) ratios. Such features indicate that they were derived from partial melting of lithospheric mantle that had been modified by fluids. The intermediate-felsic volcanic rocks consist of trachydacite and andesite, which show medium SiO<sub>2</sub> concentrations (58.31–66.44 wt. %), a wide range of Mg<sup>#</sup> values (28–53) and with A<sub>1</sub>-type granites affinities. These features, along with slightly positive to negative <i>ε</i><sub>Hf(<i>t</i>)</sub> values (+0.53 to −17.71), indicate that they originated from mixed magma of melted lower crust and mantle substances. Dacites from dikes are distinguished by high SiO<sub>2</sub> concentrations (65.72–67.2 wt. %), negative <i>ε</i><sub>Hf(<i>t</i>)</sub> values (−2.55 to −6.72) and old zircon Hf <i>T</i><sub>DM2</sub> ages (1453–1653 Ma), suggesting they were generated by melting of Mesoproterozoic and Palaeoproterozoic crustal material. All of the investigated volcanic and sub-volcanic rocks exhibit geochemical signatures of extension setting. In combination with previous studies, we suggest the Early Cretaceous extension in northeast China is related to the collapse of thickened lithosphere after closure of the Mongol–Okhotsk Ocean and to the slab break off of the Mudanjiang Ocean.
DOI: 10.6084/m9.figshare.7094246.v1
title: Early Cretaceous volcanic and sub-volcanic rocks in the Erlian Basin and adjacent areas, Northeast China: new geochemistry, geochronology and zircon Hf isotope constraints on petrogenesis and tectonic setting

description: Early Cretaceous volcanic rocks are widely distributed in northeast China and being extensively observed recently. However, petrogenesis and tectonic setting of these volcanic rocks are still on debate. We present zircon U–Pb ages, whole-rock geochemistry and zircon Hf isotope for these volcanic and sub-volcanic rocks surrounding the Erlian Basin including basic-intermediate volcanic rocks, intermediate-felsic volcanic rocks, and dacites and trachyandesite from dikes. The zircon U–Pb dating results indicate that these rocks formed in the Early Cretaceous (146–129 Ma). The basic-intermediate volcanic rocks mainly consist of basaltic andesite, which are featured by low SiO<sub>2</sub> concentrations (49.96–58.34 wt. %), high Mg<sup>#</sup> values (54–37) and Co contents (17.85–25.98 ppm), and positive <i>ε</i><sub>Hf(<i>t</i>)</sub> values (+7.11 to +13.87). Moreover, they show high La/Nb (1.79–2.87) and low La/Ba (0.02–0.08) ratios. Such features indicate that they were derived from partial melting of lithospheric mantle that had been modified by fluids. The intermediate-felsic volcanic rocks consist of trachydacite and andesite, which show medium SiO<sub>2</sub> concentrations (58.31–66.44 wt. %), a wide range of Mg<sup>#</sup> values (28–53) and with A<sub>1</sub>-type granites affinities. These features, along with slightly positive to negative <i>ε</i><sub>Hf(<i>t</i>)</sub> values (+0.53 to −17.71), indicate that they originated from mixed magma of melted lower crust and mantle substances. Dacites from dikes are distinguished by high SiO<sub>2</sub> concentrations (65.72–67.2 wt. %), negative <i>ε</i><sub>Hf(<i>t</i>)</sub> values (−2.55 to −6.72) and old zircon Hf <i>T</i><sub>DM2</sub> ages (1453–1653 Ma), suggesting they were generated by melting of Mesoproterozoic and Palaeoproterozoic crustal material. All of the investigated volcanic and sub-volcanic rocks exhibit geochemical signatures of extension setting. In combination with previous studies, we suggest the Early Cretaceous extension in northeast China is related to the collapse of thickened lithosphere after closure of the Mongol–Okhotsk Ocean and to the slab break off of the Mudanjiang Ocean.
DOI: 10.6084/m9.figshare.8142890
title: Additional file 10: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S5. Node Information of PPI. (XLSX 26â kb)
DOI: 10.6084/m9.figshare.8142890.v1
title: Additional file 10: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S5. Node Information of PPI. (XLSX 26â kb)
DOI: 10.6084/m9.figshare.8142893
title: Additional file 11: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S6. Network Information of PPI. (XLSX 23â kb)
DOI: 10.6084/m9.figshare.8142893.v1
title: Additional file 11: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S6. Network Information of PPI. (XLSX 23â kb)
DOI: 10.6084/m9.figshare.8142896
title: Additional file 1: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S1. The primer sequences for qRT-PCR. (XLSX 10â kb)
DOI: 10.6084/m9.figshare.8142896.v1
title: Additional file 1: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S1. The primer sequences for qRT-PCR. (XLSX 10â kb)
DOI: 10.6084/m9.figshare.8142902
title: Additional file 3: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S2. The detail information of identified peptides pertinent to detected proteins. (XLSX 5698â kb)
DOI: 10.6084/m9.figshare.8142902.v1
title: Additional file 3: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S2. The detail information of identified peptides pertinent to detected proteins. (XLSX 5698â kb)
DOI: 10.6084/m9.figshare.8142905
title: Additional file 4: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S3. The detail information of all identified peptides. (XLSX 1618â kb)
DOI: 10.6084/m9.figshare.16531441
title: Additional file 1 of Species and genetic variability of sweet potato viruses in China

description: Additional file 1: Table S1. Virus species detected in sweet potato fields in different provinces. Table S2. Virus isolates obtained in the present study. Table S3. Reference sequences used in the present study. Table S4. SDT analysis of sweepoviruses. Table S5. SDT analysis of SPLCHbV. Table S6. SDT analysis of SPLCGV. Table S7. SDT analysis of SPLCV. Table S8. SDT analysis of SPSMV-1. Table S9 Viruses detected from 64 samples by next-generation sequencing. Table S10. Primers used for virus detection in the present study. Table S11. Primers used for complete genome amplification in the present study.
DOI: 10.6084/m9.figshare.8142905.v1
title: Additional file 4: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S3. The detail information of all identified peptides. (XLSX 1618â kb)
DOI: 10.6084/m9.figshare.16531441.v1
title: Additional file 1 of Species and genetic variability of sweet potato viruses in China

description: Additional file 1: Table S1. Virus species detected in sweet potato fields in different provinces. Table S2. Virus isolates obtained in the present study. Table S3. Reference sequences used in the present study. Table S4. SDT analysis of sweepoviruses. Table S5. SDT analysis of SPLCHbV. Table S6. SDT analysis of SPLCGV. Table S7. SDT analysis of SPLCV. Table S8. SDT analysis of SPSMV-1. Table S9 Viruses detected from 64 samples by next-generation sequencing. Table S10. Primers used for virus detection in the present study. Table S11. Primers used for complete genome amplification in the present study.
DOI: 10.6084/m9.figshare.8142908
title: Additional file 5: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S4. The detail information of DEPs. (XLSX 91â kb)
DOI: 10.6084/m9.figshare.8142908.v1
title: Additional file 5: of Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

description: Table S4. The detail information of DEPs. (XLSX 91â kb)
DOI: 10.6084/m9.figshare.8143004
title: A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment

description: Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly resistant to conventional radiotherapy and chemotherapy, and cannot be effectively controlled by surgical resection. Due to inevitable recurrence of GBM, it remains essentially incurable with a median overall survival of less than 18 months after diagnosis. A great challenge in current therapies lies in the abrogated delivery of most of the chemotherapeutic agents to the tumor location in the presence of blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). These protective barriers serve as a selectively permeable hurdle reducing the efficacy of anti-tumor drugs in GBM therapy. This work systematically gives a comprehensive review on: (i) the characteristics of the BBB and the BBTB, (ii) the influence of BBB/BBTB on drug delivery and the screening strategy of small-molecule chemotherapeutic agents with promising BBB/BBTB-permeable potential, (iii) the strategies to overcome the BBB/BBTB as well as the techniques which can lead to transient BBB/BBTB opening or disruption allowing for improving BBB/BBTB-penetration of drugs. It is hoped that this review provide practical guidance for the future development of small BBB/BBTB-permeable agents against GBM as well as approaches enhancing drug delivery across the BBB/BBTB to GBM.
DOI: 10.6084/m9.figshare.8143004.v1
title: A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment

description: Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly resistant to conventional radiotherapy and chemotherapy, and cannot be effectively controlled by surgical resection. Due to inevitable recurrence of GBM, it remains essentially incurable with a median overall survival of less than 18 months after diagnosis. A great challenge in current therapies lies in the abrogated delivery of most of the chemotherapeutic agents to the tumor location in the presence of blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). These protective barriers serve as a selectively permeable hurdle reducing the efficacy of anti-tumor drugs in GBM therapy. This work systematically gives a comprehensive review on: (i) the characteristics of the BBB and the BBTB, (ii) the influence of BBB/BBTB on drug delivery and the screening strategy of small-molecule chemotherapeutic agents with promising BBB/BBTB-permeable potential, (iii) the strategies to overcome the BBB/BBTB as well as the techniques which can lead to transient BBB/BBTB opening or disruption allowing for improving BBB/BBTB-penetration of drugs. It is hoped that this review provide practical guidance for the future development of small BBB/BBTB-permeable agents against GBM as well as approaches enhancing drug delivery across the BBB/BBTB to GBM.
DOI: 10.6084/m9.figshare.13385888
title: Table S1:Identifying references to volcanic eruptions in Chinese historical records

description: Table summarizing suspect eruptive events of the Tianchi volcano
DOI: 10.6084/m9.figshare.13385888.v1
title: Table S1:Identifying references to volcanic eruptions in Chinese historical records

description: Table summarizing suspect eruptive events of the Tianchi volcano
DOI: 10.6084/m9.figshare.13385888.v2
title: Table S1:Identifying references to volcanic eruptions in Chinese historical records

description: Table summarizing suspect eruptive events of the Tianchi volcano
DOI: 10.6084/m9.figshare.8143025
title: Decreased expression of circ_0020397 in intracranial aneurysms may be contributing to decreased vascular smooth muscle cell proliferation via increased expression of miR-138 and subsequent decreased KDR expression

description: Dysfunction of vascular smooth muscle cells (VSMCs) mediates intracranial aneurysm (IA). KDR is reported to alleviate IA progression via promoting VSMC proliferation, while the upstream regulators are still unclear. Arterial wall tissues at the aneurysm site from 12 patients were obtained. The real-time PCR result indicated that circRNA_0020397 was down-regulated, but miR-138 was up-regulated in artery wall tissues and cells of IA. Overexpressed circRNA_0020397 promoted proliferation of human umbilical artery SMCs. MiR-138 negatively regulated KDR via binding with 3’UTR of KDR mRNA. The expression of circRNA_0020397 was negatively correlated with miR-138. In conclusion, our findings demonstrated that decreased expression of circRNA_0020397 in IA may contribute to the decreased VSMC proliferation via increasing miR-138 expression and subsequently decreasing KDR expression.
DOI: 10.6084/m9.figshare.8143025.v1
title: Decreased expression of circ_0020397 in intracranial aneurysms may be contributing to decreased vascular smooth muscle cell proliferation via increased expression of miR-138 and subsequent decreased KDR expression

description: Dysfunction of vascular smooth muscle cells (VSMCs) mediates intracranial aneurysm (IA). KDR is reported to alleviate IA progression via promoting VSMC proliferation, while the upstream regulators are still unclear. Arterial wall tissues at the aneurysm site from 12 patients were obtained. The real-time PCR result indicated that circRNA_0020397 was down-regulated, but miR-138 was up-regulated in artery wall tissues and cells of IA. Overexpressed circRNA_0020397 promoted proliferation of human umbilical artery SMCs. MiR-138 negatively regulated KDR via binding with 3’UTR of KDR mRNA. The expression of circRNA_0020397 was negatively correlated with miR-138. In conclusion, our findings demonstrated that decreased expression of circRNA_0020397 in IA may contribute to the decreased VSMC proliferation via increasing miR-138 expression and subsequently decreasing KDR expression.
DOI: 10.6084/m9.figshare.8143034
title: N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions

description: EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain of Notch3 (N3ICD) can inhibit EMT in breast cancer cells. In this study, we aimed to elucidate the influence of N3ICD or N3ICD combined with the transmembrane domain (TD+N3ICD) on the expression and distribution of TJs/AJs and polar molecules. We found that although N3ICD can upregulate the expression levels of the above-mentioned molecules, TD+N3ICD can inhibit EMT more effectively than N3ICD alone. TD+N3ICD overexpression upregulated the expression of endogenous full-length Notch3 and contributed to correcting the position of TJs/AJs molecules and better acinar structures formation. Co-immunoprecipitation results showed that the upregulated endogenous full-length Notch3 could physically interact with E-ca in MDA-MB-231/pCMV-(TD+N3ICD) cells. Collectively, our data indicate that overexpression of TD+N3ICD can effectively inhibit EMT, resulting in better positioning of TJs/AJs molecules and cell-cell adhesion in breast cancer cells. <b>Abbreviations</b>: EMT: Epithelial-mesenchymal transition; TJs: Tight junctions; AJs: Adherens junctions; aPKC: Atypical protein kinase C; Crb: Crumbs; Lgl: Lethal (2) giant larvae; LLGL2: lethal giant larvae homolog 2; PAR: Partitioning defective; PATJ: Pals1-associated TJ protein
DOI: 10.6084/m9.figshare.8143034.v2
title: N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions

description: EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain of Notch3 (N3ICD) can inhibit EMT in breast cancer cells. In this study, we aimed to elucidate the influence of N3ICD or N3ICD combined with the transmembrane domain (TD+N3ICD) on the expression and distribution of TJs/AJs and polar molecules. We found that although N3ICD can upregulate the expression levels of the above-mentioned molecules, TD+N3ICD can inhibit EMT more effectively than N3ICD alone. TD+N3ICD overexpression upregulated the expression of endogenous full-length Notch3 and contributed to correcting the position of TJs/AJs molecules and better acinar structures formation. Co-immunoprecipitation results showed that the upregulated endogenous full-length Notch3 could physically interact with E-ca in MDA-MB-231/pCMV-(TD+N3ICD) cells. Collectively, our data indicate that overexpression of TD+N3ICD can effectively inhibit EMT, resulting in better positioning of TJs/AJs molecules and cell-cell adhesion in breast cancer cells. <b>Abbreviations</b>: EMT: Epithelial-mesenchymal transition; TJs: Tight junctions; AJs: Adherens junctions; aPKC: Atypical protein kinase C; Crb: Crumbs; Lgl: Lethal (2) giant larvae; LLGL2: lethal giant larvae homolog 2; PAR: Partitioning defective; PATJ: Pals1-associated TJ protein