cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7899473.v1
title: An agent-based simulation combined with group decision-making technique for improving the performance of an emergency department

description: This study presents an agent-based simulation modeling in an emergency department. In a traditional approach, a supervisor (or a manager) allocates the resources (receptionist, nurses, doctors, etc.) to different sections based on personal experience or by using decision-support tools. In this study, each staff agent took part in the process of allocating resources based on their observation in their respective sections, which gave the system the advantage of utilizing all the available human resources during the workday by being allocated to a different section. In this simulation, unlike previous studies, all staff agents took part in the decision-making process to re-allocate the resources in the emergency department. The simulation modeled the behavior of patients, receptionists, triage nurses, emergency room nurses and doctors. Patients were able to decide whether to stay in the system or leave the department at any stage of treatment. In order to evaluate the performance of this approach, 6 different scenarios were introduced. In each scenario, various key performance indicators were investigated before and after applying the group decision-making. The outputs of each simulation were number of deaths, number of patients who leave the emergency department without being attended, length of stay, waiting time and total number of discharged patients from the emergency department. Applying the self-organizing approach in the simulation showed an average of 12.7 and 14.4% decrease in total waiting time and number of patients who left without being seen, respectively. The results showed an average increase of 11.5% in total number of discharged patients from emergency department.
DOI: 10.6084/m9.figshare.7899479.v1
title: Bioactive peptides from beef products fermented by acid whey – in vitro and in silico study

description: ABSTRACT: This research investigated the potential of beef products with acid whey to release bioactive peptides and thereby emphasize their health-promoting potential. Peptide sequences were isolated and identified by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). Firstly, the antihealth properties (toxicity, allergenicity) of the peptides were estimated based on the peptide sequences. Next, their health-promoting potential was demonstrated based on an in silico analysis by determining their bioactivity scores (PeptideRanker). Their various biological actions were also determined using BIOPEP-UWM tools. We presented peptide sequences with properties relevant to ensuring good health and well-being, including cardiovascular system, nervous and immune systems, or their support for the maintenance of general homeostasis. We obtained information on generation of biologically active peptides in uncured beef with acid whey and it can be considered as a new knowledge as it contributes to science development of functional and nutraceutical foods. In the long term, this information can be used in designing products with desired nutritional and health-promoting properties that are important for the well-being and for preventing the occurrence of noncommunicable diseases.
DOI: 10.6084/m9.figshare.7899464.v1
title: Ray Tracing and Applications to an Evaporation Duct Model Based on Data from Oceanographic Buoy Sensors

description: Abstract The two-dimensional ray tracing method allows an easy and fast modeling of tropospheric propagation in the microwave frequency range. A version of this method that determines ray trajectories, amplitudes and delays of the electromagnetic field, as well as the propagation loss in a two-dimensional inhomogeneous environment will be described. The implemented algorithm may consider generalized maps of modified refractivity (or refractive modulus), including not only the vertical gradients, but also their horizontal variations along the path between transmitter and receiver. Next, the present paper will discuss the results from the application of a model of evaporation duct height to data from instruments installed in sea buoys located along the Brazilian coast. Finally, the results from the application of the ray-tracing model to evaporation ducts will be presented, to analyze the propagation of microwave signals in the maritime environment. These results will also be compared with corresponding ones from the software Advanced Refractive Effects Prediction System 3.6, based on the numerical solution of a parabolic equation.
DOI: 10.6084/m9.figshare.7899467.v1
title: Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats

description: Posthemorrhagic shock mesenteric lymph (PHSML) is a key factor in multiple organ injury following hemorrhagic shock. We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage. A hemorrhagic shock model was established in 4 experimental groups: shock, shock+drainage, shock+drainage+PPG (45 mg/kg, 0.5 h prehemorrhage), and shock+drainage+NaHS (28 µmol/kg, 0.5 h prehemorrhage). Fluid resuscitation was performed after 1 h of hypotension, and PHMSL was drained in the last three groups for 3 h after resuscitation. Renal function and histomorphology were assessed along with levels of H2S, cystathionine-γ-lyase (CSE), Toll-like receptor 4 (TLR4), interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-α in renal tissue. Hemorrhagic shock induced AKI with increased urea and creatinine levels in plasma and higher H2S, CSE, TLR4, IL-10, IL-12, and TNF-α levels in renal tissue. PHSML drainage significantly reduced urea, creatinine, H2S, CSE, and TNF-α but not TLR4, IL-10, or IL-12. PPG decreased creatinine, H2S, IL-10, and TNF-α levels, but this effect was reversed by NaHS administration. In conclusion, PHSML drainage alleviated AKI following hemorrhagic shock by preventing increases in H2S and H2S-mediated inflammation.
DOI: 10.6084/m9.figshare.7899449
title: Analytical study of cylindrical tanks including soil-structure interaction

description: Abstract An analytical study aiming the design of cylindrical liquid storage tanks resting on deformable foundations is developed in this work. The soil under the tanks is modeled as an elastic linear medium. The cylindrical wall is considered rigidly connected to the plate foundation. Here, concrete tanks are emphasized, although the study can be extended to other construction materials. For the analysis of the design forces acting on the tanks, efficient and simplified approximate expressions are derived based on rigorous analytical theories for thin shells and circular plate on elastic foundations. To verify the proposed approximate expressions and investigate the influence of the foundation deformability on displacements and design forces, parametric analyses of concrete tanks with different soil stiffness values are presented. The results illustrate the strong influence of the foundation stiffness on the tank design quantities and a very good performance of the simplified expressions.
DOI: 10.6084/m9.figshare.7899452
title: Adherence to Multidrug-Resistant Tuberculosis (MDR-TB) Treatment: case study in a reference outpatient clinic, Niterói (RJ), Brazil

description: Abstract Background Adherence to treatment and high cure rates result from the interaction health services, patients, society and public management. Objective To determine the factors associated with adherence to multidrug-resistant tuberculosis (MDR-TB) treatment from the perspective of patients, professionals and managers. Method Case study using quali-quantitative approach, different sources of evidence, descriptive statistics and content analysis based on the categories: adherence, access, embracement, bonding and accountability. Results The free supply of medicines and exams in the clinic, flexibility of scheduling, active search for no-show patients and relationship with the health team were described as important factors for adherence. Difficult access to social benefits and absence of some professionals of health team were unfavorable factors for adherence. Knowledge of the current illness and its treatment associated with the patient's will were important aspects to overcome the barriers when conducting treatment. Conclusion Despite the existence of unfavorable factors, the actions of embracement, bonding and accountability were sufficient to promote adherence in this group. It is recommended to further promote access to welfare benefits, new forms of communication and collaboration with other public sectors and society to confront the MDR-TB.
DOI: 10.6084/m9.figshare.7899458
title: Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

description: Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed. Results revealed that FA could effectively suppress the HFD-associated increase in visceral fat accumulation, adipocyte size and body weight gain, similar to sibutramine, the positive control. FA also significantly (P&lt;0.05) decreased the HFD-induced elevations in serum lipid profiles, amylase and lipase activities, and the levels of blood glucose and insulin hormone. The markedly elevated leptin and decreased ghrelin levels seen in HFD-fed control mice were significantly (P&lt;0.05) reversed by FA treatment, almost reaching the values seen in ND-fed mice. Furthermore, FA demonstrated significant (P&lt;0.05) inhibition of serum levels of inflammatory mediators TNF-α, and MCH-1. These results suggest that FA could be beneficial in lowering the risk of HFD-induced obesity via modulation of enzymatic, hormonal and inflammatory responses.
DOI: 10.6084/m9.figshare.7899461.v1
title: A numerical analysis of a concrete slab breaching using high explosives

description: Abstract Explosive breaching of walls, demolition of buildings with high structural robustness and non-programmed explosions may be extremely dangerous, the high risk of these events demands continuous researches to support the development of optimized constructive techniques and design. In this context, this work presents a numerical study of the explosive breaching of concrete wall using an optimized contact explosive charge with cilindrical shape, the CFD software Autodyn ® Ansys was used. The results were evaluated in terms of damage pattern of the concrete slab, where was considered the cratering dimensions, the breakthrough hole and concrete spalling. A significant gain of the destructive potential of the explosive was observed by the simple rearrangement of its dimensions when compared to the base model, also the robustness of software to model and simulate a complex experiment that involves the detonation of a contact explosive charge was verified.
DOI: 10.6084/m9.figshare.7899449.v1
title: Analytical study of cylindrical tanks including soil-structure interaction

description: Abstract An analytical study aiming the design of cylindrical liquid storage tanks resting on deformable foundations is developed in this work. The soil under the tanks is modeled as an elastic linear medium. The cylindrical wall is considered rigidly connected to the plate foundation. Here, concrete tanks are emphasized, although the study can be extended to other construction materials. For the analysis of the design forces acting on the tanks, efficient and simplified approximate expressions are derived based on rigorous analytical theories for thin shells and circular plate on elastic foundations. To verify the proposed approximate expressions and investigate the influence of the foundation deformability on displacements and design forces, parametric analyses of concrete tanks with different soil stiffness values are presented. The results illustrate the strong influence of the foundation stiffness on the tank design quantities and a very good performance of the simplified expressions.
DOI: 10.6084/m9.figshare.7899452.v1
title: Adherence to Multidrug-Resistant Tuberculosis (MDR-TB) Treatment: case study in a reference outpatient clinic, Niterói (RJ), Brazil

description: Abstract Background Adherence to treatment and high cure rates result from the interaction health services, patients, society and public management. Objective To determine the factors associated with adherence to multidrug-resistant tuberculosis (MDR-TB) treatment from the perspective of patients, professionals and managers. Method Case study using quali-quantitative approach, different sources of evidence, descriptive statistics and content analysis based on the categories: adherence, access, embracement, bonding and accountability. Results The free supply of medicines and exams in the clinic, flexibility of scheduling, active search for no-show patients and relationship with the health team were described as important factors for adherence. Difficult access to social benefits and absence of some professionals of health team were unfavorable factors for adherence. Knowledge of the current illness and its treatment associated with the patient's will were important aspects to overcome the barriers when conducting treatment. Conclusion Despite the existence of unfavorable factors, the actions of embracement, bonding and accountability were sufficient to promote adherence in this group. It is recommended to further promote access to welfare benefits, new forms of communication and collaboration with other public sectors and society to confront the MDR-TB.
DOI: 10.6084/m9.figshare.7899446
title: Coronary Artery Bypass Surgery in Brazil: Analysis of the National Reality Through the BYPASS Registry

description: Abstract Introduction: Coronary artery bypass grafting (CABG) is the most frequently performed heart surgery in Brazil. Recent international guidelines recommend that national societies establish a database on the practice and results of CABG. In anticipation of the recommendation, the BYPASS Registry was introduced in 2015. Objective: To analyze the profile, risk factors and outcomes of patients undergoing CABG in Brazil, as well as to examine the predominant surgical strategy, based on the data included in the BYPASS Registry. Methods: A cross-sectional study of 2292 patients undergoing CABG surgery and cataloged in the BYPASS Registry up to November 2018. Demographic data, clinical presentation, operative variables, and postoperative hospital outcomes were analyzed. Results: Patients referred to CABG in Brazil are predominantly male (71%), with prior myocardial infarction in 41.1% of cases, diabetes in 42.5%, and ejection fraction lower than 40% in 9.7%. The Heart Team indicated surgery in 32.9% of the cases. Most of the patients underwent cardiopulmonary bypass (87%), and cardioplegia was the strategy of myocardial protection chosen in 95.2% of the cases. The left internal thoracic artery was used as a graft in 91% of the cases; the right internal thoracic artery, in 5.6%; and the radial artery in 1.1%. The saphenous vein graft was used in 84.1% of the patients, being the only graft employed in 7.7% of the patients. The median number of coronary vessels treated was 3. Operative mortality was 2.8%, and the incidence of cerebrovascular accident was 1.2%. Conclusion: CABG data in Brazil provided by the BYPASS Registry analysis are representative of our national reality and practice. This database constitutes an important reference for indications and comparisons of therapeutic procedures, as well as to propose subsequent models to improve patient safety and the quality of surgical practice in the country.
DOI: 10.6084/m9.figshare.7899458.v1
title: Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

description: Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed. Results revealed that FA could effectively suppress the HFD-associated increase in visceral fat accumulation, adipocyte size and body weight gain, similar to sibutramine, the positive control. FA also significantly (P&lt;0.05) decreased the HFD-induced elevations in serum lipid profiles, amylase and lipase activities, and the levels of blood glucose and insulin hormone. The markedly elevated leptin and decreased ghrelin levels seen in HFD-fed control mice were significantly (P&lt;0.05) reversed by FA treatment, almost reaching the values seen in ND-fed mice. Furthermore, FA demonstrated significant (P&lt;0.05) inhibition of serum levels of inflammatory mediators TNF-α, and MCH-1. These results suggest that FA could be beneficial in lowering the risk of HFD-induced obesity via modulation of enzymatic, hormonal and inflammatory responses.
DOI: 10.6084/m9.figshare.7899440
title: Prognostic significance of the dynamic changes of systemic inflammatory response in metastatic renal cell carcinoma

description: ABSTRACT Purpose: To elucidate the prognostic value of systemic inflammatory response in patients with metastatic renal cell carcinoma (mRCC) who are treated with sunitinib, we evaluated the prognostic role of C-reactive protein (CRP) kinetics. This study also compared prognostic models containing CRP kinetics and neutrophil-to-lymphocyte ratio (NLR) kinetics. Materials and Methods: A consecutive cohort of 94 patients with mRCC who were treated with sunitinib was retrospectively included from Fudan University Shanghai Cancer Center. According to dynamic changes in CRP and the NLR, patients were divided into three groups for analysis of CRP and NLR kinetics. The associations between survival and potential prognostic factors were assessed. The incremental value of prognostication was evaluated. Results: A significant difference (P&lt;0.001) in overall survival (OS) was observed among the three groups of CRP kinetics. The median OS of the non-elevated group was nearly 1.3-fold longer than that of the normalized group (33.0 vs. 26.3 months), and two times longer than that of the non-normalized group (33.0 vs. 14.0 months). Multivariate analysis showed that CRP and NLR kinetics were independent prognostic indicators. The model containing CRP kinetics had a better predictive accuracy than that with NLR kinetics, which was supported by the C-index (0.731 vs. 0.684) and the likelihood ratio χ2 test (79.9% vs. 44.9%). Conclusion: Our study suggests that dynamic changes in CRP can better predict survival in patients with mRCC who are treated with sunitinib. Routine assessment of CRP before and after targeted therapy would help identify patients at risk of a poor outcome.
DOI: 10.6084/m9.figshare.7899443
title: Effect of Preoperative Creatinine Levels on Mortality after Coronary Artery Bypass Grafting Surgery: an Observational Study

description: Abstract Introduction: Renal function is an independent risk factor for mortality among on-pump coronary bypass grafting (ONCABG) patients. This association is well known in the international literature, but there is a lack of knowledge of how admission creatinine (AC) levels modulate each cardiovascular risk factor. Objective: The aim of this paper was to assess the effect of different AC levels on mortality among ONCABG patients. Methods: 1,599 patients who underwent ONCABG between December 1999 and February 2006 at Hospital de Base in São José do Rio Preto/SP-Brazil were included. They were divided into quartiles according to their AC levels (QI: 0.2 ≤AC &lt; 1.0 mg/dL; QII: 1.0 ≤ AC &lt; 1.2 mg/dL; QIII: 1.2 ≤ AC &lt; 1.4 mg/dL; and QIV: 1.4 ≤ AC ≤ 2.6 mg/dL). Seven risk factors were then evaluated in each stratum. Results: Mortality was higher in the QIV group than QI or QII groups. Factors such as age (≥ 65 years) and cardiopulmonary bypass (CPB) time (≥ 115 minutes) in QIV, as well preoperative hospital stay (≥ 5 days) in QIII, were associated with higher mortality rates. Creatinine variation greater than or equal to 0.4 mg/dL increased mortality rates in all groups. The use of intra-aortic balloon pump and dialysis increased mortality rates in all groups except for QII. Type I neurological dysfunction increased the mortality rate in the QII and III groups. Conclusion: Creatinine levels play an important role in ONCABG mortality. The combination of selected risk factors and higher AC values leads to a worse prognosis. On the other hand, lower AC values were associated with a protective effect, even among elderly patients and those with a high CPB time.
DOI: 10.6084/m9.figshare.7899446.v1
title: Coronary Artery Bypass Surgery in Brazil: Analysis of the National Reality Through the BYPASS Registry

description: Abstract Introduction: Coronary artery bypass grafting (CABG) is the most frequently performed heart surgery in Brazil. Recent international guidelines recommend that national societies establish a database on the practice and results of CABG. In anticipation of the recommendation, the BYPASS Registry was introduced in 2015. Objective: To analyze the profile, risk factors and outcomes of patients undergoing CABG in Brazil, as well as to examine the predominant surgical strategy, based on the data included in the BYPASS Registry. Methods: A cross-sectional study of 2292 patients undergoing CABG surgery and cataloged in the BYPASS Registry up to November 2018. Demographic data, clinical presentation, operative variables, and postoperative hospital outcomes were analyzed. Results: Patients referred to CABG in Brazil are predominantly male (71%), with prior myocardial infarction in 41.1% of cases, diabetes in 42.5%, and ejection fraction lower than 40% in 9.7%. The Heart Team indicated surgery in 32.9% of the cases. Most of the patients underwent cardiopulmonary bypass (87%), and cardioplegia was the strategy of myocardial protection chosen in 95.2% of the cases. The left internal thoracic artery was used as a graft in 91% of the cases; the right internal thoracic artery, in 5.6%; and the radial artery in 1.1%. The saphenous vein graft was used in 84.1% of the patients, being the only graft employed in 7.7% of the patients. The median number of coronary vessels treated was 3. Operative mortality was 2.8%, and the incidence of cerebrovascular accident was 1.2%. Conclusion: CABG data in Brazil provided by the BYPASS Registry analysis are representative of our national reality and practice. This database constitutes an important reference for indications and comparisons of therapeutic procedures, as well as to propose subsequent models to improve patient safety and the quality of surgical practice in the country.