cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11609298
title: IMPLICATION OF MICROWAVES ON THE EXTRACTION PROCESS OF RICE BRAN PROTEIN

description: Abstract During the processing of rice grain, a wide range of by-products are generated, including Rice Bran (RB), which presents rich composition, offering great potential for application in the food and pharmaceutical industries. Thus, the objective of this work was to evaluate the best operating variables in the extraction of rice bran protein through alkaline extraction and Microwave-Assisted Extraction (MAE). It was found that MAE, in similar conditions, resulted in a higher yield of protein extraction and protein content in the extracted material in a relatively shorter process time, when compared to the values obtained in the alkaline extraction (MAE: yield: 22.04% higher, protein content: 6.19% higher, 30 times faster). In addition, the characterization of the extracts obtained showed that the use of microwaves did not affect the extracted rice bran proteins. Thus, it was possible to verify that MAE is potent and a strongly advisable technique for obtaining rice bran protein.
DOI: 10.6084/m9.figshare.11609298.v1
title: IMPLICATION OF MICROWAVES ON THE EXTRACTION PROCESS OF RICE BRAN PROTEIN

description: Abstract During the processing of rice grain, a wide range of by-products are generated, including Rice Bran (RB), which presents rich composition, offering great potential for application in the food and pharmaceutical industries. Thus, the objective of this work was to evaluate the best operating variables in the extraction of rice bran protein through alkaline extraction and Microwave-Assisted Extraction (MAE). It was found that MAE, in similar conditions, resulted in a higher yield of protein extraction and protein content in the extracted material in a relatively shorter process time, when compared to the values obtained in the alkaline extraction (MAE: yield: 22.04% higher, protein content: 6.19% higher, 30 times faster). In addition, the characterization of the extracts obtained showed that the use of microwaves did not affect the extracted rice bran proteins. Thus, it was possible to verify that MAE is potent and a strongly advisable technique for obtaining rice bran protein.
DOI: 10.6084/m9.figshare.11609292
title: Asymptomatic Huge Cardiac Hydatid Cyst Located in the Interventricular Septum

description: Abstract The cardiac involvement of hydatid cyst, which is rarely seen, with the location of asymptomatic huge cyst in the interventricular septum (IVS) is an extraordinary condition. We report an isolated cardiac hydatid cyst located in the IVS in an 18-year-old man diagnosed incidentally by transthoracic echocardiography. Cardiac magnetic resonance imaging confirmed a mass lesion of 47×74 mm in diameter located at the base of IVS. The cystic content and its germinative membrane were resected and the cavity was applicated under cardiopulmonary bypass. Postoperative course was uneventful and the patient was discharged on the 6th postoperative day, with oral albendazole therapy.
DOI: 10.6084/m9.figshare.11609295
title: Renal sympathetic denervation for resistant hypertension: where do we stand after more than a decade

description: Abstract Despite the current availability of safe and efficient drugs for treating hypertension, a substantial number of patients are drug-resistant hypertensives. Aiming this condition, a relatively new approach named catheter-based renal denervation was developed. We have now a clinically relevant time window to review the efficacy of renal denervation for treating this form of hypertension. This short review addresses the physiological contribution of renal sympathetic nerves for blood pressure control and discusses the pros and cons of renal denervation procedure for the treatment of resistant hypertension.
DOI: 10.6084/m9.figshare.11609289
title: Primary Biatrial Cardiac Rhabdomyosarcoma

description: Abstract Primary malignant neoplasms of the heart are rare. Cardiac rhabdomyosarcoma is the second most common primary sarcoma. We report a rare case of a 49-year-old woman with a huge biatrial cardiac rhabdomyosarcoma treated by performing surgical resection followed by salvage chemotherapy for local recurrence. Cardiac sarcoma that occupy both atria are extremely rare. Although the prognosis of cardiac rhabdomyosarcoma is dismal, surgical resection should be recommended as a first line therapy to clarify the diagnosis and to relieve symptoms associated with the tumor.
DOI: 10.6084/m9.figshare.11609295.v1
title: Renal sympathetic denervation for resistant hypertension: where do we stand after more than a decade

description: Abstract Despite the current availability of safe and efficient drugs for treating hypertension, a substantial number of patients are drug-resistant hypertensives. Aiming this condition, a relatively new approach named catheter-based renal denervation was developed. We have now a clinically relevant time window to review the efficacy of renal denervation for treating this form of hypertension. This short review addresses the physiological contribution of renal sympathetic nerves for blood pressure control and discusses the pros and cons of renal denervation procedure for the treatment of resistant hypertension.
DOI: 10.6084/m9.figshare.11609292.v1
title: Asymptomatic Huge Cardiac Hydatid Cyst Located in the Interventricular Septum

description: Abstract The cardiac involvement of hydatid cyst, which is rarely seen, with the location of asymptomatic huge cyst in the interventricular septum (IVS) is an extraordinary condition. We report an isolated cardiac hydatid cyst located in the IVS in an 18-year-old man diagnosed incidentally by transthoracic echocardiography. Cardiac magnetic resonance imaging confirmed a mass lesion of 47×74 mm in diameter located at the base of IVS. The cystic content and its germinative membrane were resected and the cavity was applicated under cardiopulmonary bypass. Postoperative course was uneventful and the patient was discharged on the 6th postoperative day, with oral albendazole therapy.
DOI: 10.6084/m9.figshare.11609283
title: Classification of Special Interest Groups (SIGs) from the Telemedicine University Network (RUTE) in Homogeneous Groups Based on their Production in Communication, Cooperation and Coordination (3C)

description: ABSTRACT Introduction The Telemedicine University Network (RUTE) in Brazil is an initiative that promotes collaboration between university hospitals, teaching hospitals, health professionals, and students using information and communication technology infrastructure to support special interest groups (SIGs) in health care. Health professionals in RUTE-member institutions plan a program of video conferences and/or web conferences to discuss specific themes. This article presents the results of an analysis of the collaboration between the Special Interest Groups (SIGs) of the Telemedicine University Network (RUTE) considering the SIGs production in communication, cooperation and coordination (3C). Methods A survey was applied to SIG coordinators between April and May 2016. The classification of SIGs into homogeneous groups considered the activities developed in the network between 2007 and the time of the survey application. The study is retrospectively based on historical data from units, institutions and SIGs. The coordinators of 71 RUTE SIGs were invited to respond. Of those, forty-five active SIGs responded to the evaluation survey in its entirety and were considered in the analyses. Results Almost one third of the respondent coordinators (35%) stated that their SIG works in the education axis, 21% work in the care and research, development and innovation axes, while 12% work in management and 11% in evaluation. The SIGs were grouped into three homogeneous categories: emergent collaboration, collaborative development, and full collaboration, and it was identified that 71% of the 45 SIGs (11 in the emerging and 20 developing groups) use email as the main extra-session communication tool. Four SIGs from the full collaboration group reported: use of instant messaging service (1 SIG), own website (1 SIG) and social networks (2 SIGs). Conclusion The results of this study suggests may not accurately gauge the actual production and collaboration that SIGs develop and this analysis can be considered as a starting point or as a reference for the RUTE community. However, the results suggest significant growth in collaboration between RUTE-member SIGs, indicating a positive trend for the RUTE regarding the interest, participation and dissemination of actions in telemedicine and telehealth in the country.
DOI: 10.6084/m9.figshare.11609286
title: Training-Intervention in Primary Care, a Pedagogical Gamble on Medical Education

description: ABSTRACT The implementation of the Unified Health System and the recognition of primary health care as a reorientation of the health care model have brought about the need for new training processes that incorporate teaching and learning into work processes. We present an experience report on the implementation of the Basic Care Fundamentals I and II modules (FABS I and FABS II), offered to students of a public university in the northeast of Brazil. With a module-based structure, the tutorial model is adopted as a pedagogical orientation and starts from the longitudinal presupposition, ensuring the student maintains continuous and consistent contact with the topics addressed and with the PHC services and the other nodes that make up the health network. Bi-annual meetings strengthen the consolidation of the teaching-service relationship, providing a permanent evaluation of the processes experienced in the Health Units, in a reflective, historical, critical and transformative perspective. The first module represents a theoretical-practical introduction to PHC and the second module, focused on professional development and social commitment, deepens the theoretical-practical notions about PHC and the physician’s performance in this context. After each tutorial, the students experience, in the meetings with and from within the Family Health Units, the topics addressed and their relationship with the territory and with those who live and work there. In the context of undergraduate health training, involving students in the daily primary care routine is fundamental, considering the inseparable nature of theory and practice, the conversation circle as a democratic method in tutoring, and the supply and demand of the themes in collective discussion. We broadened our analysis of the role of the teacher-supporter, as a dual function to support both student and care network involved in the training-intervention process. The enhancement of the teaching-service-community integration contributes to the training of professionals for the country’s health system and implies the defense of political guidelines for the legitimacy and sustainability of primary care.
DOI: 10.6084/m9.figshare.11609289.v1
title: Primary Biatrial Cardiac Rhabdomyosarcoma

description: Abstract Primary malignant neoplasms of the heart are rare. Cardiac rhabdomyosarcoma is the second most common primary sarcoma. We report a rare case of a 49-year-old woman with a huge biatrial cardiac rhabdomyosarcoma treated by performing surgical resection followed by salvage chemotherapy for local recurrence. Cardiac sarcoma that occupy both atria are extremely rare. Although the prognosis of cardiac rhabdomyosarcoma is dismal, surgical resection should be recommended as a first line therapy to clarify the diagnosis and to relieve symptoms associated with the tumor.
DOI: 10.6084/m9.figshare.11609283.v1
title: Classification of Special Interest Groups (SIGs) from the Telemedicine University Network (RUTE) in Homogeneous Groups Based on their Production in Communication, Cooperation and Coordination (3C)

description: ABSTRACT Introduction The Telemedicine University Network (RUTE) in Brazil is an initiative that promotes collaboration between university hospitals, teaching hospitals, health professionals, and students using information and communication technology infrastructure to support special interest groups (SIGs) in health care. Health professionals in RUTE-member institutions plan a program of video conferences and/or web conferences to discuss specific themes. This article presents the results of an analysis of the collaboration between the Special Interest Groups (SIGs) of the Telemedicine University Network (RUTE) considering the SIGs production in communication, cooperation and coordination (3C). Methods A survey was applied to SIG coordinators between April and May 2016. The classification of SIGs into homogeneous groups considered the activities developed in the network between 2007 and the time of the survey application. The study is retrospectively based on historical data from units, institutions and SIGs. The coordinators of 71 RUTE SIGs were invited to respond. Of those, forty-five active SIGs responded to the evaluation survey in its entirety and were considered in the analyses. Results Almost one third of the respondent coordinators (35%) stated that their SIG works in the education axis, 21% work in the care and research, development and innovation axes, while 12% work in management and 11% in evaluation. The SIGs were grouped into three homogeneous categories: emergent collaboration, collaborative development, and full collaboration, and it was identified that 71% of the 45 SIGs (11 in the emerging and 20 developing groups) use email as the main extra-session communication tool. Four SIGs from the full collaboration group reported: use of instant messaging service (1 SIG), own website (1 SIG) and social networks (2 SIGs). Conclusion The results of this study suggests may not accurately gauge the actual production and collaboration that SIGs develop and this analysis can be considered as a starting point or as a reference for the RUTE community. However, the results suggest significant growth in collaboration between RUTE-member SIGs, indicating a positive trend for the RUTE regarding the interest, participation and dissemination of actions in telemedicine and telehealth in the country.
DOI: 10.6084/m9.figshare.11609280
title: The neurology behind three wounded French artists during the great world war

description: Abstract A unique association joins Guillaume Apollinaire, Blaise Cendrars and Louis Ferdinand Céline. Besides being great exponents of French literature, they were all neurologically wounded during the First World War. Apollinaire had a traumatic brain injury, Cendrars developed phantom limb neuropathic pain and Céline presented radial nerve paralysis. There is quite an evidence that supports that their artistic output was also influenced by acquired neurological conditions during the war. The examples of these three French authors reveal the surprising intimacy Neurology can share with art and history.
DOI: 10.6084/m9.figshare.11609286.v1
title: Training-Intervention in Primary Care, a Pedagogical Gamble on Medical Education

description: ABSTRACT The implementation of the Unified Health System and the recognition of primary health care as a reorientation of the health care model have brought about the need for new training processes that incorporate teaching and learning into work processes. We present an experience report on the implementation of the Basic Care Fundamentals I and II modules (FABS I and FABS II), offered to students of a public university in the northeast of Brazil. With a module-based structure, the tutorial model is adopted as a pedagogical orientation and starts from the longitudinal presupposition, ensuring the student maintains continuous and consistent contact with the topics addressed and with the PHC services and the other nodes that make up the health network. Bi-annual meetings strengthen the consolidation of the teaching-service relationship, providing a permanent evaluation of the processes experienced in the Health Units, in a reflective, historical, critical and transformative perspective. The first module represents a theoretical-practical introduction to PHC and the second module, focused on professional development and social commitment, deepens the theoretical-practical notions about PHC and the physician’s performance in this context. After each tutorial, the students experience, in the meetings with and from within the Family Health Units, the topics addressed and their relationship with the territory and with those who live and work there. In the context of undergraduate health training, involving students in the daily primary care routine is fundamental, considering the inseparable nature of theory and practice, the conversation circle as a democratic method in tutoring, and the supply and demand of the themes in collective discussion. We broadened our analysis of the role of the teacher-supporter, as a dual function to support both student and care network involved in the training-intervention process. The enhancement of the teaching-service-community integration contributes to the training of professionals for the country’s health system and implies the defense of political guidelines for the legitimacy and sustainability of primary care.
DOI: 10.6084/m9.figshare.11609274
title: RESISTANCE TRAINING IMPROVES THE BLOOD PRESSURE AND FUNCTIONAL PERFORMANCE OF INDIVIDUALS WITH T2DM

description: ABSTRACT Introduction: Studies presenting the benefits in people with type 2 Diabetes Mellitus (T2DM) undergoing resistance training with one exercise for each muscle group, with three sets at the same intensity. Objective: To compare functional capacity and blood pressure before and after weight training. Methods: Twenty-three patients participated in a weight training program. Maximum strength and functional assessment tests were performed for the lower and upper limbs. The intervention time was 16 weeks, 12 of which consisted of training and four of evaluations. There was an increase in volume with the number of exercises and an increase in intensity with incremental weights. Results: There was significant improvement in most of the functional tests. In the 5x sit-to-stand test in the pre-training period, nine patients recorded times greater than 13.6 seconds. In the post-training period, four maintained the above time, but two reduced the time from 16.1 and 19.6 to 13.9 seconds. In the maximum load strength test there are a significant increase in both upper and lower limbs with 20.8% and 23.4%, respectively. After the training period, there was a significant reduction in systolic blood pressure both at rest and after exercise. Conclusion: The weight training program improved muscle strength, functional capacity and blood pressure in patients with type 2 diabetes mellitus. Level of evidence IV; Therapeutic study - Investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.11609277
title: Effect of a novel bioceramic root canal sealer on the angiogenesis-enhancing potential of assorted human odontogenic stem cells compared with principal tricalcium silicate-based cements

description: Abstract Objective: This study evaluated the angiogenesis-enhancing potential of a tricalcium silicate-based mineral trioxide aggregate (ProRoot MTA), Biodentine, and a novel bioceramic root canal sealer (Well-Root ST) in human dental pulp stem cells (hDPSCs), human periodontal ligament stem cells (hPLSCs), and human tooth germ stem cells (hTGSCs). Methodology: Dulbecco's modified Eagle's medium was conditioned for 24 h by exposure to ProRoot MTA, Biodentine, or Well-Root ST specimens (prepared according to the manufacturers’ instructions). The cells were cultured in these conditioned media and their viability was assessed with 3-(4,5-dimethyl-thiazol-2-yl)-5-(3-carboxy-methoxy-phenyl)-2-(4-sulfo-phenyl)-2H tetrazolium (MTS) on days 1, 3, 7, 10, and 14. Angiogenic growth factors [platelet-derived growth factor (PDGF), basic ﬁbroblast growth factor (FGF-2), and vascular endothelial growth factor (VEGF)] were assayed by sandwich enzyme-linked immunosorbent assay (ELISA) on days 1, 7, and 14. Human umbilical vein endothelial cell (HUVEC) migration assays were used to evaluate the vascular effects of the tested materials at 6–8 h. Statistical analyses included Kruskal–Wallis, Mann–Whitney U, and Friedman and Wilcoxon signed rank tests. Results: None of tricalcium silicate-based materials were cytotoxic and all induced a similar release of angiogenic growth factors (PDGF, FGF-2, and VEGF) (p&gt;0.05). The best cell viability was observed for hDPSCs (p&lt;0.05) with all tricalcium silicate-based materials at day 14. Tube formation by HUVECs showed a significant increase with all tested materials (p&lt;0.05). Conclusion: The tricalcium silicate-based materials showed potential for angiogenic stimulation of all stem cell types and significantly enhanced tube formation by HUVECs.
DOI: 10.6084/m9.figshare.11609277.v1
title: Effect of a novel bioceramic root canal sealer on the angiogenesis-enhancing potential of assorted human odontogenic stem cells compared with principal tricalcium silicate-based cements

description: Abstract Objective: This study evaluated the angiogenesis-enhancing potential of a tricalcium silicate-based mineral trioxide aggregate (ProRoot MTA), Biodentine, and a novel bioceramic root canal sealer (Well-Root ST) in human dental pulp stem cells (hDPSCs), human periodontal ligament stem cells (hPLSCs), and human tooth germ stem cells (hTGSCs). Methodology: Dulbecco's modified Eagle's medium was conditioned for 24 h by exposure to ProRoot MTA, Biodentine, or Well-Root ST specimens (prepared according to the manufacturers’ instructions). The cells were cultured in these conditioned media and their viability was assessed with 3-(4,5-dimethyl-thiazol-2-yl)-5-(3-carboxy-methoxy-phenyl)-2-(4-sulfo-phenyl)-2H tetrazolium (MTS) on days 1, 3, 7, 10, and 14. Angiogenic growth factors [platelet-derived growth factor (PDGF), basic ﬁbroblast growth factor (FGF-2), and vascular endothelial growth factor (VEGF)] were assayed by sandwich enzyme-linked immunosorbent assay (ELISA) on days 1, 7, and 14. Human umbilical vein endothelial cell (HUVEC) migration assays were used to evaluate the vascular effects of the tested materials at 6–8 h. Statistical analyses included Kruskal–Wallis, Mann–Whitney U, and Friedman and Wilcoxon signed rank tests. Results: None of tricalcium silicate-based materials were cytotoxic and all induced a similar release of angiogenic growth factors (PDGF, FGF-2, and VEGF) (p&gt;0.05). The best cell viability was observed for hDPSCs (p&lt;0.05) with all tricalcium silicate-based materials at day 14. Tube formation by HUVECs showed a significant increase with all tested materials (p&lt;0.05). Conclusion: The tricalcium silicate-based materials showed potential for angiogenic stimulation of all stem cell types and significantly enhanced tube formation by HUVECs.