cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5930968
title: Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment

description: Abstract Introduction The aetiology of sudden hearing loss is poorly defined; however, infectious, vascular and neoplastic aetiologies are presumed to be responsible. In addition, the aetiology of bilateral sudden hearing loss is also unknown. Objective The objective of this study is identify the characteristics and treatment response of simultaneous bilateral sudden hearing loss. Methods This is a case-control study that practised in tertiary care academic centre. 132 patients with sudden hearing loss who were treated with systemic steroid and hyperbaric oxygen together were included. 26 patients had bilateral sudden hearing loss and 106 patients had unilateral sudden hearing loss. Patients were evaluated with clinical, audiological and radiological examinations and laboratory tests were done. Findings and response to treatment of the patients were compared. Results The mean ages of patients with unilateral and bilateral sudden hearing loss were 42.0 years and 24.5 years respectively with a statistically significant difference (p &lt; 0.001). Immune response markers were more prevalent in bilateral sudden hearing loss. Pre-treatment audiologic thresholds were 69.1 dB for unilateral sudden hearing loss and 63.3 dB for the left ears and 67.6 dB for the right ears for bilateral sudden hearing loss without significant difference. Post-treatment average hearing threshold in unilateral sudden hearing loss was 47.0 dB and 55.4 dB for the left ears and 59.0 for the right ears in bilateral sudden hearing loss. Average hearing improvement in unilateral sudden hearing loss group was significant (p &lt; 0.001) in spite of it was not significant in bilateral sudden hearing loss group for both ears. Between the groups; there was a significant difference for hearing improvement favouring unilateral sudden hearing loss (p &lt; 0.001). Tinnitus scores decreased significantly in both groups of patients (p &lt; 0.001) in spite of there was no significant difference between the groups of patients. Conclusion Patients with bilateral sudden hearing loss showed lower age, worse prognosis and higher rate of positive immune response markers. Cardiovascular risk factors seem to have an important role in the aetiology of unilateral cases whereas this importance was not present in bilateral ones.
DOI: 10.6084/m9.figshare.5930968.v1
title: Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment

description: Abstract Introduction The aetiology of sudden hearing loss is poorly defined; however, infectious, vascular and neoplastic aetiologies are presumed to be responsible. In addition, the aetiology of bilateral sudden hearing loss is also unknown. Objective The objective of this study is identify the characteristics and treatment response of simultaneous bilateral sudden hearing loss. Methods This is a case-control study that practised in tertiary care academic centre. 132 patients with sudden hearing loss who were treated with systemic steroid and hyperbaric oxygen together were included. 26 patients had bilateral sudden hearing loss and 106 patients had unilateral sudden hearing loss. Patients were evaluated with clinical, audiological and radiological examinations and laboratory tests were done. Findings and response to treatment of the patients were compared. Results The mean ages of patients with unilateral and bilateral sudden hearing loss were 42.0 years and 24.5 years respectively with a statistically significant difference (p &lt; 0.001). Immune response markers were more prevalent in bilateral sudden hearing loss. Pre-treatment audiologic thresholds were 69.1 dB for unilateral sudden hearing loss and 63.3 dB for the left ears and 67.6 dB for the right ears for bilateral sudden hearing loss without significant difference. Post-treatment average hearing threshold in unilateral sudden hearing loss was 47.0 dB and 55.4 dB for the left ears and 59.0 for the right ears in bilateral sudden hearing loss. Average hearing improvement in unilateral sudden hearing loss group was significant (p &lt; 0.001) in spite of it was not significant in bilateral sudden hearing loss group for both ears. Between the groups; there was a significant difference for hearing improvement favouring unilateral sudden hearing loss (p &lt; 0.001). Tinnitus scores decreased significantly in both groups of patients (p &lt; 0.001) in spite of there was no significant difference between the groups of patients. Conclusion Patients with bilateral sudden hearing loss showed lower age, worse prognosis and higher rate of positive immune response markers. Cardiovascular risk factors seem to have an important role in the aetiology of unilateral cases whereas this importance was not present in bilateral ones.
DOI: 10.6084/m9.figshare.5930959
title: DEVELOPING AN INDEX FOR FOREST PRODUCTIVITY MAPPING - A CASE STUDY FOR MARITIME PINE PRODUCTION REGULATION IN PORTUGAL

description: ABSTRACT Productivity is very dependent on the environmental and biotic factors present at the site where the forest species of interest is present. Forest site productivity is usually assessed using empirical models applied to inventory data providing discrete predictions. While the use of GIS-based models enables building a site productivity distribution map. Therefore, the aim of this study was to derive a productivity index using multivariate statistics and coupled GIS-geostatistics to obtain a forest productivity map. To that end, a study area vastly covered by naturally regenerated forests of maritime pine in central Portugal was used. First, a productivity index (PI) was built based on Factorial Correspondence Analysis (FCA) by incorporating a classical site index for the species and region (Sh25 - height index model) and GIS-derived environmental variables (slope and aspect). After, the PI map was obtained by multi-Gaussian kriging and used as a GIS layer to evaluate maritime pine areas by productivity class (e.g., low, intermediate and high). In the end, the area control method was applied to assess the size and the number of compartments to establish by productivity class. The management compartments of equal productivity were digitized as GIS layer and organized in a temporal progression of stands’ age regularly available for cutting each year during a 50-year schedule. The methodological approach developed in this study proved that can be used to build forest productivity maps which are crucial tools to support forest production regulation.
DOI: 10.6084/m9.figshare.5930959.v1
title: DEVELOPING AN INDEX FOR FOREST PRODUCTIVITY MAPPING - A CASE STUDY FOR MARITIME PINE PRODUCTION REGULATION IN PORTUGAL

description: ABSTRACT Productivity is very dependent on the environmental and biotic factors present at the site where the forest species of interest is present. Forest site productivity is usually assessed using empirical models applied to inventory data providing discrete predictions. While the use of GIS-based models enables building a site productivity distribution map. Therefore, the aim of this study was to derive a productivity index using multivariate statistics and coupled GIS-geostatistics to obtain a forest productivity map. To that end, a study area vastly covered by naturally regenerated forests of maritime pine in central Portugal was used. First, a productivity index (PI) was built based on Factorial Correspondence Analysis (FCA) by incorporating a classical site index for the species and region (Sh25 - height index model) and GIS-derived environmental variables (slope and aspect). After, the PI map was obtained by multi-Gaussian kriging and used as a GIS layer to evaluate maritime pine areas by productivity class (e.g., low, intermediate and high). In the end, the area control method was applied to assess the size and the number of compartments to establish by productivity class. The management compartments of equal productivity were digitized as GIS layer and organized in a temporal progression of stands’ age regularly available for cutting each year during a 50-year schedule. The methodological approach developed in this study proved that can be used to build forest productivity maps which are crucial tools to support forest production regulation.
DOI: 10.6084/m9.figshare.5930956
title: Relation analysis of the occurrence of single nucleotide polymorphism of the DOCK9 gene in keratoconus

description: ABSTRACT Objective: To evaluate the occurrence of a mutation in candidate genetic loci and its relation with keratoconus in patients treated in Brazil compared to healthy volunteers, through analysis of single nucleotide polymorphism in the DOCK9 gene. Methods: In this clinical study, 108 participants were evaluated, including 46 keratoconus patients and 62 healthy volunteers (controls). DNA samples were extracted from collected blood from keratoconus patients and controls. The genotyping of the single nucleotide polymorphism rs7995432 in the DOCK9 gene was determined through a real-time polymerase chain reaction (qPCR). Results: The frequency of the mutant allele (C) was 4.8% in patients and 7.6% in controls. For the wild allele (T), the frequencies were 95.2% in patients and 92.4% in controls. The heterozygous genotype was present in 9.5% of patients and 11% of controls, while the homozygous genotype for the wild allele (TT) was found in 90.5% and 87% for patients and controls, respectively. Conclusion: There were no significant differences un the frequency and discrimination of the mutant and wild alleles between patients and controls. Therefore, these results confirm no association of these mutations in the DOCK9 gene and the occurrence of keratoconus for this population.
DOI: 10.6084/m9.figshare.5930956.v1
title: Relation analysis of the occurrence of single nucleotide polymorphism of the DOCK9 gene in keratoconus

description: ABSTRACT Objective: To evaluate the occurrence of a mutation in candidate genetic loci and its relation with keratoconus in patients treated in Brazil compared to healthy volunteers, through analysis of single nucleotide polymorphism in the DOCK9 gene. Methods: In this clinical study, 108 participants were evaluated, including 46 keratoconus patients and 62 healthy volunteers (controls). DNA samples were extracted from collected blood from keratoconus patients and controls. The genotyping of the single nucleotide polymorphism rs7995432 in the DOCK9 gene was determined through a real-time polymerase chain reaction (qPCR). Results: The frequency of the mutant allele (C) was 4.8% in patients and 7.6% in controls. For the wild allele (T), the frequencies were 95.2% in patients and 92.4% in controls. The heterozygous genotype was present in 9.5% of patients and 11% of controls, while the homozygous genotype for the wild allele (TT) was found in 90.5% and 87% for patients and controls, respectively. Conclusion: There were no significant differences un the frequency and discrimination of the mutant and wild alleles between patients and controls. Therefore, these results confirm no association of these mutations in the DOCK9 gene and the occurrence of keratoconus for this population.
DOI: 10.6084/m9.figshare.5930953
title: Osteonecrosis of the jaws: a review and update in etiology and treatment

description: Abstract Introduction Osteonecrosis of the jaws can result either from radiation, used in radiotherapy for treatment of malignant tumors, or medications used for bone remodeling and anti-angiogenesis such as bisphosphonates. These conditions can be associated with triggering factors such as infection, trauma and decreased vascularity. The management of patients with osteonecrosis of the jaws requires caution since there is no specific treatment that acts isolated and decidedly. However, different treatment modalities can be employed in an associated manner to control and stabilize lesions. Objective To review the current knowledge on etiology and management of osteonecrosis of the jaws, both radio-induced and medication-related, aiming to improve knowledge of professionals seeking to improve the quality of life of their patients. Methods Literature review in PubMed as well as manual search for relevant publications in reference list of selected articles. Articles in English ranging from 1983 to 2017, which assessed osteonecrosis of the jaws as main objective, were selected and analyzed. Results Infections, traumas and decreased vascularity have a triggering role for osteonecrosis of the jaws. Prophylactic and/or stabilizing measures can be employed in association with therapeutic modalities to properly manage osteonecrosis of the jaws patients. Conclusion Selecting an appropriate therapy for osteonecrosis of the jaws management based on current literature is a rational decision that can help lead to a proper treatment plan.
DOI: 10.6084/m9.figshare.5930953.v1
title: Osteonecrosis of the jaws: a review and update in etiology and treatment

description: Abstract Introduction Osteonecrosis of the jaws can result either from radiation, used in radiotherapy for treatment of malignant tumors, or medications used for bone remodeling and anti-angiogenesis such as bisphosphonates. These conditions can be associated with triggering factors such as infection, trauma and decreased vascularity. The management of patients with osteonecrosis of the jaws requires caution since there is no specific treatment that acts isolated and decidedly. However, different treatment modalities can be employed in an associated manner to control and stabilize lesions. Objective To review the current knowledge on etiology and management of osteonecrosis of the jaws, both radio-induced and medication-related, aiming to improve knowledge of professionals seeking to improve the quality of life of their patients. Methods Literature review in PubMed as well as manual search for relevant publications in reference list of selected articles. Articles in English ranging from 1983 to 2017, which assessed osteonecrosis of the jaws as main objective, were selected and analyzed. Results Infections, traumas and decreased vascularity have a triggering role for osteonecrosis of the jaws. Prophylactic and/or stabilizing measures can be employed in association with therapeutic modalities to properly manage osteonecrosis of the jaws patients. Conclusion Selecting an appropriate therapy for osteonecrosis of the jaws management based on current literature is a rational decision that can help lead to a proper treatment plan.
DOI: 10.6084/m9.figshare.5930950
title: Sucessfull management of bilateral presumed Candida endogenous endophtalmitis following pancreatitis

description: ABSTRACT Endogenous endophthalmitis is a rare, and frequently devastating, ophthalmic disease. It occurs mostly in immunocompromised patients, or those with diabetes mellitus, cancer or intravenous drugs users. Candida infection is the most common cause of endogenous endophthalmitis. Ocular candidiasis develops within days to weeks of fungemia. The association of treatment for pancreatitis with endophthalmitis is unusual. Treatment with broad-spectrum antibiotics and total parenteral nutrition may explain endogenous endophthalmitis. We report the case of a patient with pancreatitis treated with broad-spectrum antibiotics and total parenteral nutrition who developed bilateral presumed Candida endogenous endophthalmitis that was successfully treated with vitrectomy and intravitreal amphotericin B.
DOI: 10.6084/m9.figshare.5930950.v1
title: Sucessfull management of bilateral presumed Candida endogenous endophtalmitis following pancreatitis

description: ABSTRACT Endogenous endophthalmitis is a rare, and frequently devastating, ophthalmic disease. It occurs mostly in immunocompromised patients, or those with diabetes mellitus, cancer or intravenous drugs users. Candida infection is the most common cause of endogenous endophthalmitis. Ocular candidiasis develops within days to weeks of fungemia. The association of treatment for pancreatitis with endophthalmitis is unusual. Treatment with broad-spectrum antibiotics and total parenteral nutrition may explain endogenous endophthalmitis. We report the case of a patient with pancreatitis treated with broad-spectrum antibiotics and total parenteral nutrition who developed bilateral presumed Candida endogenous endophthalmitis that was successfully treated with vitrectomy and intravitreal amphotericin B.
DOI: 10.6084/m9.figshare.5930947
title: Resistance to Cowpea aphid-borne mosaic virus in in vitro germinated genotypes of Passiflora setacea

description: ABSTRACT Passion fruit (Passiflora edulis) is a fruit species of great relevance for Brazilian economy. However, it is highly susceptible to the Cowpea aphid-borne mosaic virus (CABMV). The species P.setacea, on the other hand, is resistant to the disease. The present study aimed to identify CABMV-resistant P. setacea genotypes for the introgression of genes into sour passion fruit genetic breeding programs. The seeds of passion fruit genotypes were germinated in vitro in MS culture medium. The seedlings were acclimatized in a growth chamber at the temperature of 27 ± 2ºC, photoperiod of 16:8 hours and 80% of relative humidity. Thirty plants of each genotype were mechanically inoculated with extract prepared from leaves collected from passion fruit plants with symptoms of CABMV for the assessment of resistance to CABMV. The severity of leaf symptoms was evaluated by means of a grading scale of visual signs. After the visual evaluation and identification of the asymptomatic genotypes of P. setacea, the PTA-ELISA test was carried out for 30 selected genotypes. According to the visual evaluation, all P. setacea genotypes were highly resistant to CABMV, while the P. edulis genotypes were highly susceptible. Out of the 30 genotypes selected, only PsRJ 4 was considered susceptible by PTA-ELISA. The other genotypes of P. setacea were considered resistant and present great potential for use in passion fruit genetic breeding programs.
DOI: 10.6084/m9.figshare.5930947.v1
title: Resistance to Cowpea aphid-borne mosaic virus in in vitro germinated genotypes of Passiflora setacea

description: ABSTRACT Passion fruit (Passiflora edulis) is a fruit species of great relevance for Brazilian economy. However, it is highly susceptible to the Cowpea aphid-borne mosaic virus (CABMV). The species P.setacea, on the other hand, is resistant to the disease. The present study aimed to identify CABMV-resistant P. setacea genotypes for the introgression of genes into sour passion fruit genetic breeding programs. The seeds of passion fruit genotypes were germinated in vitro in MS culture medium. The seedlings were acclimatized in a growth chamber at the temperature of 27 ± 2ºC, photoperiod of 16:8 hours and 80% of relative humidity. Thirty plants of each genotype were mechanically inoculated with extract prepared from leaves collected from passion fruit plants with symptoms of CABMV for the assessment of resistance to CABMV. The severity of leaf symptoms was evaluated by means of a grading scale of visual signs. After the visual evaluation and identification of the asymptomatic genotypes of P. setacea, the PTA-ELISA test was carried out for 30 selected genotypes. According to the visual evaluation, all P. setacea genotypes were highly resistant to CABMV, while the P. edulis genotypes were highly susceptible. Out of the 30 genotypes selected, only PsRJ 4 was considered susceptible by PTA-ELISA. The other genotypes of P. setacea were considered resistant and present great potential for use in passion fruit genetic breeding programs.
DOI: 10.6084/m9.figshare.5930944
title: The Precarious Mobilizers: social basis and fight for popular housing in the cities of Recife and Jaboatão dos Guararapes, PE

description: Abstract This article discusses the political-economic transformations triggered by the capitalism restructuring and its repercussion in urban spaces, essentially cities that are commonly transformed into places of strategic development, urban entrepreneurship and overlap extraction. These changes lead to social contradictions and inequality among classes, especially for a precarious and neglected population facing deprivation of essential elements. In this study, we refer to this population as Precarious Mobilizers. We analyzed the work of a homeless movement in the cities of Recife and Jaboatão dos Guararapes, evaluating the conjuncture of their social base (political, economic and social) and the political repercussion of these collective subjects in the conquest of the houses and in facing an exclusionary model. We used empirical monitoring of occupational nuclei in the aforementioned cities and questionnaires among the families that are part of the movement in question. The study describes their methods to fight inequality and characterize the families involved in the movement.
DOI: 10.6084/m9.figshare.5930944.v1
title: The Precarious Mobilizers: social basis and fight for popular housing in the cities of Recife and Jaboatão dos Guararapes, PE

description: Abstract This article discusses the political-economic transformations triggered by the capitalism restructuring and its repercussion in urban spaces, essentially cities that are commonly transformed into places of strategic development, urban entrepreneurship and overlap extraction. These changes lead to social contradictions and inequality among classes, especially for a precarious and neglected population facing deprivation of essential elements. In this study, we refer to this population as Precarious Mobilizers. We analyzed the work of a homeless movement in the cities of Recife and Jaboatão dos Guararapes, evaluating the conjuncture of their social base (political, economic and social) and the political repercussion of these collective subjects in the conquest of the houses and in facing an exclusionary model. We used empirical monitoring of occupational nuclei in the aforementioned cities and questionnaires among the families that are part of the movement in question. The study describes their methods to fight inequality and characterize the families involved in the movement.
DOI: 10.6084/m9.figshare.5930941
title: Ophthalmologic findings in Gaucher's disease type III: case report

description: Abstract We report a case of a patient with Guacher's disease type III, with mutation in Exon9, 1246G&gt; A and 1251G&gt; C, seeking to investigate the suspected glaucoma, to describe the ophthalmological findings, as glycolipid accumulation in the pre-retinal region and to investigate The possible correlation with the decrease of the layer of nerve fibers.
DOI: 10.6084/m9.figshare.5930941.v1
title: Ophthalmologic findings in Gaucher's disease type III: case report

description: Abstract We report a case of a patient with Guacher's disease type III, with mutation in Exon9, 1246G&gt; A and 1251G&gt; C, seeking to investigate the suspected glaucoma, to describe the ophthalmological findings, as glycolipid accumulation in the pre-retinal region and to investigate The possible correlation with the decrease of the layer of nerve fibers.