cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12094290
title: The accessibility and the inclusion in a Higher Education Federal Institution since the law no. 13.409

description: ABSTRACT The current study aims to analyze the adequation process of a Higher Education Federal Institution to law no. 13.409, of December 28th, 2016, which implements quotas for people with disabilities. It is a qualitative research of a single case. Two managers of the Institution were interviewed and researched documents related to the theme for our documental corpus were collected. For the documental analysis, the content analysis procedure was used. It was found that the analyzed institution does not have adequate conditions to meet the quota for people with disabilities established by the law. It is concluded that, even though law no. 13.409/2016 is fair and necessary, the conditions for its effectiveness by part of the federal government were not created. What should have been inclusion is, in fact, a process of exclusion.
DOI: 10.6084/m9.figshare.12094293
title: Ultrasonographic diagnosis of twins in two pregnant bitches: case report

description: ABSTRACT Multiple pregnancies in humans account for only 3% of pregnancies, 97-98% of which are twin pregnancies and the morbimortality is higher in the monochorionic twins when compared to dichorionic ones. The canine species is naturally multiparous, but the diagnosis of monochorionic twin pregnancy is not common. The objective of this report was to describe the ultrasonographic diagnosis of monochorionic twin pregnancies in two bitches [Pug (case 1) and Shih tzu (case 2)]. It was possible to verify the presence of one gestational vesicle containing two fetuses in each female by observing two heads or two bodies within the same placental site. These fetuses presented adequate viability and normal organogenesis. Their development was similar to the other fetuses. In case 1 they were stillborn and smaller than the other five live-born fetuses. The twins in case 2 were born alive, but they also appeared smaller when compared to the littermates. The gestational risks associated with this condition in pregnant bitches are still unknown, however, there are reports of fetal death in monochorionic pregnancies in this species. Therefore, ultrasonographic exam during pregnancy allows an early monochorionic diagnosis and monitoring the fetal viability could bring health benefits to both the female and the littermates.
DOI: 10.6084/m9.figshare.12860165.v1
title: R0186_20170903a_videos

description: Rat 0186, skilled reaching data collected on 9/3/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12094287
title: Potentially toxic metals of vegetable gardens of urban schools in Lages, Santa Catarina, Brazil

description: ABSTRACT: Urban environments are contaminated in many ways with persistent organic and inorganic pollutants as a result of anthropogenic activities, endangering human health and natural resources. The objective of the present study was to evaluate the soil contamination by cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in 10 vegetable gardens of urban schools located near or on Botucatu sandstone outcrops of Guarani Aquifer in the urban areas of Lages, Santa Catarina, Brazil. In each garden, three soil samples at each position (in the soil immediately outside and the soil in the garden) were collected at a depth of 0-20 cm. The ISO 11466 method was used to extract the metals. Inductively coupled plasma optical emission spectrometry was used to quantify the elements and certified materials to evaluate the quantities (SRM 2709a - San Joaquin Soil - NIST). To evaluate the data, principal component analyses and cluster analyses were performed. The cluster analysis for the evaluated metals showed that the highest contents of elements were reported in three gardens. Values above the prevention value defined by resolution no. 420/2005 of the National Council for the Environment -Conselho Nacional do Meio Ambiente (CONAMA) - were reported for cobalt in one garden and copper in three gardens; thus, these areas were categorized as Class III areas. Principal component analysis explained 74.7% of the data and showed the enrichment of some elements within gardens.
DOI: 10.6084/m9.figshare.12094293.v1
title: Ultrasonographic diagnosis of twins in two pregnant bitches: case report

description: ABSTRACT Multiple pregnancies in humans account for only 3% of pregnancies, 97-98% of which are twin pregnancies and the morbimortality is higher in the monochorionic twins when compared to dichorionic ones. The canine species is naturally multiparous, but the diagnosis of monochorionic twin pregnancy is not common. The objective of this report was to describe the ultrasonographic diagnosis of monochorionic twin pregnancies in two bitches [Pug (case 1) and Shih tzu (case 2)]. It was possible to verify the presence of one gestational vesicle containing two fetuses in each female by observing two heads or two bodies within the same placental site. These fetuses presented adequate viability and normal organogenesis. Their development was similar to the other fetuses. In case 1 they were stillborn and smaller than the other five live-born fetuses. The twins in case 2 were born alive, but they also appeared smaller when compared to the littermates. The gestational risks associated with this condition in pregnant bitches are still unknown, however, there are reports of fetal death in monochorionic pregnancies in this species. Therefore, ultrasonographic exam during pregnancy allows an early monochorionic diagnosis and monitoring the fetal viability could bring health benefits to both the female and the littermates.
DOI: 10.6084/m9.figshare.12860165
title: R0186_20170903a_videos

description: Rat 0186, skilled reaching data collected on 9/3/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12094290.v1
title: The accessibility and the inclusion in a Higher Education Federal Institution since the law no. 13.409

description: ABSTRACT The current study aims to analyze the adequation process of a Higher Education Federal Institution to law no. 13.409, of December 28th, 2016, which implements quotas for people with disabilities. It is a qualitative research of a single case. Two managers of the Institution were interviewed and researched documents related to the theme for our documental corpus were collected. For the documental analysis, the content analysis procedure was used. It was found that the analyzed institution does not have adequate conditions to meet the quota for people with disabilities established by the law. It is concluded that, even though law no. 13.409/2016 is fair and necessary, the conditions for its effectiveness by part of the federal government were not created. What should have been inclusion is, in fact, a process of exclusion.
DOI: 10.6084/m9.figshare.12094287.v1
title: Potentially toxic metals of vegetable gardens of urban schools in Lages, Santa Catarina, Brazil

description: ABSTRACT: Urban environments are contaminated in many ways with persistent organic and inorganic pollutants as a result of anthropogenic activities, endangering human health and natural resources. The objective of the present study was to evaluate the soil contamination by cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in 10 vegetable gardens of urban schools located near or on Botucatu sandstone outcrops of Guarani Aquifer in the urban areas of Lages, Santa Catarina, Brazil. In each garden, three soil samples at each position (in the soil immediately outside and the soil in the garden) were collected at a depth of 0-20 cm. The ISO 11466 method was used to extract the metals. Inductively coupled plasma optical emission spectrometry was used to quantify the elements and certified materials to evaluate the quantities (SRM 2709a - San Joaquin Soil - NIST). To evaluate the data, principal component analyses and cluster analyses were performed. The cluster analysis for the evaluated metals showed that the highest contents of elements were reported in three gardens. Values above the prevention value defined by resolution no. 420/2005 of the National Council for the Environment -Conselho Nacional do Meio Ambiente (CONAMA) - were reported for cobalt in one garden and copper in three gardens; thus, these areas were categorized as Class III areas. Principal component analysis explained 74.7% of the data and showed the enrichment of some elements within gardens.
DOI: 10.6084/m9.figshare.12094275
title: Effects of yacon flour associated with an energy restricted diet on intestinal permeability, fecal short chain fatty acids, oxidative stress and inflammation markers levels in adults with obesity or overweight: a randomized, double blind, placebo controlled clinical trial

description: ABSTRACT Objectives Yacon flour is rich in bioactive compounds (phenolic compounds and fructooligosaccharides (FOS)), and may therefore reduce the risk of diseases associated with excess body weight. However, its effect on fecal short chain fatty acids (SCFA), intestinal permeability, oxidative stress and inflammation markers has not been studied in adult humans with excess body weight. Thus, we evaluated the effect of the consumption of yacon flour on these variables. Materials and methods Twenty-six excess body weight (30.4 ± 2.4 kg/m2) adults (31.3 ± 8.5y) were randomized to one of two groups (yacon flour or control; n = 13) on a double blind clinical trial. Subjects received a breakfast drink containing or not yacon flour (25g) associated with an energy restricted diet, for six weeks. The flour chemical characterization, FOS and total phenolics contents were evaluated. Antioxidant capacity was evaluated in vitro and in vivo (plasma). Intestinal permeability, fecal SCFA, oxidative stress and inflammatory markers also were evaluated in vivo. Results Yacon flour was well tolerated. It presented an in vitro and in vivo antioxidant capacity, increased plasma total antioxidant capacity (ΔYAC: 49.16 (-4.20; 156.63)) and reduced protein carbonyl concentrations (ΔYAC: -0.98 (-1.54; -0.42)). A reduction in SCFAs was observed in both groups (Δacetic: -3.16 (-5.07; -0.95) vs. -1.05 (-2.65; 1.11); Δpropionic: -1.05 (-2.60;-0.38) vs. -0.41 (-2.08; 0.09); Δbutyric: -0.75 (-1.38; -0.04) vs. -0.28 (-0.98; 0.11), for YAC and CON, respectively). Other variables did not change. Conclusion The yacon flour increased the plasma antioxidant capacity, decreased oxidative stress and SCFAs in adults with obesity or overweight.
DOI: 10.6084/m9.figshare.12094278
title: Permanent diabetes insipidus in a patient with mesothelioma treated with immunotherapy

description: SUMMARY Checkpoint inhibitors have substantially improved the prognosis for patients with advanced malignancy. Treatment with immunomodulants has the ability to reactivate the immune system against tumor cells, but can also trigger the development of immune-related adverse events that reflects a loss of tolerance of the immune system for self-antigens. Regarding the endocrine system, thyroid and pituitary are the most frequent glands involved; in particular hypophysitis is commonly observed with anti-CTLA4 with a variable impaired anterior pituitary dysfunction (mainly ACTH and TSH dysregulation) while a posterior pituitary dysfunction has been rarely described. A 68-year-old man with a diagnosis of metastatic mesothelioma started in September 2016 first-line treatment with tremelimumab and durvalumab. After 3 cycles he presented sudden onset of polydipsia and polyuria without other symptoms. Diagnostic work-up, including a water deprivation test, established a diagnosis of central diabetes insipidus. Patient started sublingual desmopressin 60 mcg three times a day, that was subsequently increased up to 480 mcg/die. At magnetic resonance imaging the posterior lobe of pituitary gland did not show high signal intensity on T1-weighted images. After regression of diabetes insipidus symptoms under desmopressin, patient restarted cancer treatment and received additional 10 doses without worsening of endocrinological toxicity or further treatment-related toxicities, maintaining the same desmopressin dosage. Posterior pituitary dysfunction has been rarely observed in patients treated with immunomodulants. To our knowledge, this is the first observation of permanent central diabetes insipidus in patients treated with combined immune checkpoint inhibitors (tremelimumab and durvalumab).
DOI: 10.6084/m9.figshare.12094272
title: Health-related quality of life associated with diabetic retinopathy in patients at a public primary care service in southern Brazil

description: ABSTRACT Objective This study aimed to establish the utility values of different health states associated with diabetic retinopathy in a Brazilian sample to provide input to model-based economic evaluations. Subjects and methods This cross-sectional study was performed in a sample of patients with type 2 diabetes mellitus (T2D) who underwent teleophthalmology screening at a primary care service from 2014 to 2016. Five diabetic retinopathy health states were defined: absent, non-sight-threatening, sight-threatening, and bilateral blindness. Utility values were estimated using the Brazilian EuroQol five dimensions (EQ-5D) tariffs. Descriptive statistics were calculated. Analysis of covariance was performed to adjust the utility values for potential confounders. Results The study included 206 patients. The mean (± standard deviation [SD]) utility value was 0.765 ± 0.19 (95% confidence interval [CI], 0.740–0.790). The adjusted mean utility value was 0.748 (95% CI, 0.698–0.798) in patients without diabetic retinopathy, 0.752 (95% CI, 0.679–0.825) in those with non-sight-threatening state, 0.628 (95% CI, 0.521–0.736) in those with sight-threatening state, and 0.355 (95% CI, 0.105–0.606) in those with bilateral blindness. A significant utility decrement was found between patients without diabetic retinopathy and those with a sight-threatening health state (0.748 vs. 0.628, respectively, p = 0.04). Conclusions The findings suggest that a later diabetic retinopathy health state is associated with a decrement in utility value compared with the absence of retinopathy in patients with T2D. The results may be useful as preliminary input to model-based economic evaluations. Further research is needed to investigate the impact of diabetic retinopathy on health-related quality of life in a sample more representative of the Brazilian population.
DOI: 10.6084/m9.figshare.12094275.v1
title: Effects of yacon flour associated with an energy restricted diet on intestinal permeability, fecal short chain fatty acids, oxidative stress and inflammation markers levels in adults with obesity or overweight: a randomized, double blind, placebo controlled clinical trial

description: ABSTRACT Objectives Yacon flour is rich in bioactive compounds (phenolic compounds and fructooligosaccharides (FOS)), and may therefore reduce the risk of diseases associated with excess body weight. However, its effect on fecal short chain fatty acids (SCFA), intestinal permeability, oxidative stress and inflammation markers has not been studied in adult humans with excess body weight. Thus, we evaluated the effect of the consumption of yacon flour on these variables. Materials and methods Twenty-six excess body weight (30.4 ± 2.4 kg/m2) adults (31.3 ± 8.5y) were randomized to one of two groups (yacon flour or control; n = 13) on a double blind clinical trial. Subjects received a breakfast drink containing or not yacon flour (25g) associated with an energy restricted diet, for six weeks. The flour chemical characterization, FOS and total phenolics contents were evaluated. Antioxidant capacity was evaluated in vitro and in vivo (plasma). Intestinal permeability, fecal SCFA, oxidative stress and inflammatory markers also were evaluated in vivo. Results Yacon flour was well tolerated. It presented an in vitro and in vivo antioxidant capacity, increased plasma total antioxidant capacity (ΔYAC: 49.16 (-4.20; 156.63)) and reduced protein carbonyl concentrations (ΔYAC: -0.98 (-1.54; -0.42)). A reduction in SCFAs was observed in both groups (Δacetic: -3.16 (-5.07; -0.95) vs. -1.05 (-2.65; 1.11); Δpropionic: -1.05 (-2.60;-0.38) vs. -0.41 (-2.08; 0.09); Δbutyric: -0.75 (-1.38; -0.04) vs. -0.28 (-0.98; 0.11), for YAC and CON, respectively). Other variables did not change. Conclusion The yacon flour increased the plasma antioxidant capacity, decreased oxidative stress and SCFAs in adults with obesity or overweight.
DOI: 10.6084/m9.figshare.12094278.v1
title: Permanent diabetes insipidus in a patient with mesothelioma treated with immunotherapy

description: SUMMARY Checkpoint inhibitors have substantially improved the prognosis for patients with advanced malignancy. Treatment with immunomodulants has the ability to reactivate the immune system against tumor cells, but can also trigger the development of immune-related adverse events that reflects a loss of tolerance of the immune system for self-antigens. Regarding the endocrine system, thyroid and pituitary are the most frequent glands involved; in particular hypophysitis is commonly observed with anti-CTLA4 with a variable impaired anterior pituitary dysfunction (mainly ACTH and TSH dysregulation) while a posterior pituitary dysfunction has been rarely described. A 68-year-old man with a diagnosis of metastatic mesothelioma started in September 2016 first-line treatment with tremelimumab and durvalumab. After 3 cycles he presented sudden onset of polydipsia and polyuria without other symptoms. Diagnostic work-up, including a water deprivation test, established a diagnosis of central diabetes insipidus. Patient started sublingual desmopressin 60 mcg three times a day, that was subsequently increased up to 480 mcg/die. At magnetic resonance imaging the posterior lobe of pituitary gland did not show high signal intensity on T1-weighted images. After regression of diabetes insipidus symptoms under desmopressin, patient restarted cancer treatment and received additional 10 doses without worsening of endocrinological toxicity or further treatment-related toxicities, maintaining the same desmopressin dosage. Posterior pituitary dysfunction has been rarely observed in patients treated with immunomodulants. To our knowledge, this is the first observation of permanent central diabetes insipidus in patients treated with combined immune checkpoint inhibitors (tremelimumab and durvalumab).
DOI: 10.6084/m9.figshare.12094266
title: Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity

description: ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is among the activators that can stimulate thermogenesis in the white adipose tissue and brown adipose tissue. People with obesity have elevated blood levels of FGF21, but also develop resistance to its action, impairing its beneficial role. Inversely, clinical treatments to weight loss has been pointed out as an important therapy for increasing and recovering sensitivity to FGF21. The aim was to analyse the effect of long-term weight loss interdisciplinary intervention on FGF21 and body composition. Subjects and methods Eighty-six post-pubertal obese adolescents (14-19 years-old), were submitted to 20 weeks of weight loss therapy (clinical, nutritional, psychological and physical exercise support). Anthropometric measures, body composition and rest metabolic rate (RMR) by bioelectrical impedance, and serum FGF21 sample by ELISA were evaluated. The adolescents were grouped according to FGF21 individual delta variations after therapy: Higher Increase (HI); lower increase (LI); lower decrease (LD); higher decrease (HD). Results All groups present weight loss. Only in FGF21 ≥ 76,5 pg/mL variation the free-fat-mass and rest metabolic rate were preserved and to others group these variables were significantly reduced. Conclusion High increase in FGF21 can contribute to preservation of FFM and RMR after weight loss therapy, could have important implications for energy balance regulation. Future studies are necessary to continue determining the role of magnitude effects of FGF21 levels in obesity to improve clinical practice, especially in paediatrics population.
DOI: 10.6084/m9.figshare.12094272.v1
title: Health-related quality of life associated with diabetic retinopathy in patients at a public primary care service in southern Brazil

description: ABSTRACT Objective This study aimed to establish the utility values of different health states associated with diabetic retinopathy in a Brazilian sample to provide input to model-based economic evaluations. Subjects and methods This cross-sectional study was performed in a sample of patients with type 2 diabetes mellitus (T2D) who underwent teleophthalmology screening at a primary care service from 2014 to 2016. Five diabetic retinopathy health states were defined: absent, non-sight-threatening, sight-threatening, and bilateral blindness. Utility values were estimated using the Brazilian EuroQol five dimensions (EQ-5D) tariffs. Descriptive statistics were calculated. Analysis of covariance was performed to adjust the utility values for potential confounders. Results The study included 206 patients. The mean (± standard deviation [SD]) utility value was 0.765 ± 0.19 (95% confidence interval [CI], 0.740–0.790). The adjusted mean utility value was 0.748 (95% CI, 0.698–0.798) in patients without diabetic retinopathy, 0.752 (95% CI, 0.679–0.825) in those with non-sight-threatening state, 0.628 (95% CI, 0.521–0.736) in those with sight-threatening state, and 0.355 (95% CI, 0.105–0.606) in those with bilateral blindness. A significant utility decrement was found between patients without diabetic retinopathy and those with a sight-threatening health state (0.748 vs. 0.628, respectively, p = 0.04). Conclusions The findings suggest that a later diabetic retinopathy health state is associated with a decrement in utility value compared with the absence of retinopathy in patients with T2D. The results may be useful as preliminary input to model-based economic evaluations. Further research is needed to investigate the impact of diabetic retinopathy on health-related quality of life in a sample more representative of the Brazilian population.
DOI: 10.6084/m9.figshare.12094257
title: Health education in Aedes aegypti: case study

description: ABSTRACT Objectives: Reporting the experience of health education regarding Aedes aegypti in the Federal District. Methods: This is a case report, with descriptive approach, about the experience of nursing practice with education actions against the Aedes aegypti in communities of the Federal District, carried out between 2015 and 2018. Subjects of the research were undergraduate students in nursing, healthcare professionals, and the community. Results: There have been 24 educational interventions against Aedes aegypti, adapted to the needs of each population, using a “giant” sculpture of the mosquito, theater performances, lectures, booklets, and home visits. Conclusions: The project trained teachers, healthcare professionals, graduate students in nursing, and the community through the empowerment of this population, aiming at combating the Aedes aegypti vector.