cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2hg92c
title: CCDC 2307642: Experimental Crystal Structure Determination

description: Related Article: Aaron DG Campbell, Natalie J Roper, Paul G Waddell, Corinne Wills, Casey M. Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong|2024|Chem.Commun.|60|3818|doi:10.1039/D4CC00268G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hg93d
title: CCDC 2307643: Experimental Crystal Structure Determination

description: Related Article: Aaron DG Campbell, Natalie J Roper, Paul G Waddell, Corinne Wills, Casey M. Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong|2024|Chem.Commun.|60|3818|doi:10.1039/D4CC00268G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hg94f
title: CCDC 2307644: Experimental Crystal Structure Determination

description: Related Article: Aaron DG Campbell, Natalie J Roper, Paul G Waddell, Corinne Wills, Casey M. Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong|2024|Chem.Commun.|60|3818|doi:10.1039/D4CC00268G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hg95g
title: CCDC 2307645: Experimental Crystal Structure Determination

description: Related Article: Aaron DG Campbell, Natalie J Roper, Paul G Waddell, Corinne Wills, Casey M. Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong|2024|Chem.Commun.|60|3818|doi:10.1039/D4CC00268G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hg96h
title: CCDC 2307646: Experimental Crystal Structure Determination

description: Related Article: Aaron DG Campbell, Natalie J Roper, Paul G Waddell, Corinne Wills, Casey M. Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong|2024|Chem.Commun.|60|3818|doi:10.1039/D4CC00268G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2hg97j
title: CCDC 2307647: Experimental Crystal Structure Determination

description: Related Article: Aaron DG Campbell, Natalie J Roper, Paul G Waddell, Corinne Wills, Casey M. Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong|2024|Chem.Commun.|60|3818|doi:10.1039/D4CC00268G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.34770/dq61-gf89
title: Data for "Chasing the multi-modal plasma response in MAST-U"

description: This deposit contains the data created for the manuscript. Figures 1 and 2
 are fit of the experimental data from the MAST-U experiment. The rest of
 the data were created with the MARS-F code (Liu et al 2000 Phys. Plasmas 7
 3681) and analyzed using ad hoc python scripts.
DOI: 10.15468/dl.jnh6jr
title: Occurrence Download

description: A dataset containing 178996 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aesculus hippocastanum L."
 ]
}

 The dataset includes 178996 records from 1318 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0083493-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/hunn-ouc1sto1649614
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649613
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649615
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649616
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649617
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649618
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649619
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649620
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649622
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649623
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649624
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649625
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649626
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649627
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649628
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649631
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649629
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649630
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649632
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649633
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649636
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649651
title: Dwayne Hunn Collection, 1966-2007
DOI: 10.25549/hunn-ouc1sto1649637
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649650
title: Dwayne Hunn's Travels
DOI: 10.5281/zenodo.10203325
title: Data package

description: Here we report the full dataset used for the manuscript 'Tracing the Scale of Fluid Flow in Subduction Zone Forearcs: Implications from Fluid-Mobile Elements' submitted to the journal Chemical Geology. The reader is referred to the Methods section for a detailed description of the analytical protocols.
Contents of the file
Table A.1. Sample locations, pressure-temperature estimates based on Raman Spectroscopy of Carbonaceous Material and multi-phase equilibrium model, and salinity of fluid inclusions in vein samples.
Table A.2. Whole-rock major and trace element composition of metapelites from the Kodiak Complex and the Shimanto Belt, as well as values of duplicates, blank, and standards.
Table A.3. LA-ICP-MS analyses of reference material used for calibration and to monitor the data quality.
Table A.4. Trace element concentrations in illite (ill), albite (ab), chlorite (chl), and vein calcite (Cc) determined by LA-ICP-MS.
Table A.5. Chemical composition of fluid inclusions analyzed by LA-ICP-MS and semi-quantified by the charge-balance approach.
DOI: 10.5281/zenodo.10658679
title: Data package

description: Here we report the full dataset used for the manuscript 'Tracing the Scale of Fluid Flow in Subduction Zone Forearcs: Implications from Fluid-Mobile Elements' submitted to the journal Chemical Geology. The reader is referred to the Methods section for a detailed description of the analytical protocols.

Contents of the file

Table A.1. Sample locations, pressure-temperature estimates based on Raman Spectroscopy of Carbonaceous Material and multi-phase equilibrium model, and salinity of fluid inclusions in vein samples.

Table A.2. Whole-rock major and trace element composition of metapelites from the Kodiak Complex and the Shimanto Belt, as well as values of duplicates, blank, and standards.

Table A.3. LA-ICP-MS analyses of reference material used for calibration and to monitor the data quality.

Table A.4. Trace element concentrations in illite (ill), albite (ab), chlorite (chl), and vein calcite (Cc) determined by LA-ICP-MS.

Table A.5. Chemical composition of fluid inclusions analyzed by LA-ICP-MS and semi-quantified by the charge-balance approach.

Figure A.1. Transient LA-ICP-MS signals of analyzed elements in FI-poor and FI-rich areas of quartz.
DOI: 10.25549/hunn-ouc1sto1649638
title: Dwayne Hunn Collection, 1966-2007
DOI: 10.25549/hunn-ouc1sto1649639
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649640
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649641
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649642
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649652
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649643
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649644
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649645
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649648
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649649
title: Dwayne Hunn's Travels
DOI: 10.34740/kaggle/dsv/7626945
title: Public Opinion Russia Ukraine War (Updated Daily)
DOI: 10.25549/hunn-ouc1sto1649646
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649647
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649653
title: Rubel Castle
DOI: 10.25402/fon.19130960.v1
title: Supplementary Tables – Treatment Patterns and Outcomes following Disease Progression on Anti-PD-1 Therapies for Advanced Melanoma

description: <b>Supplemental
 Table 1. Treatment Patterns after Index Line for the Anti-programmed Cell
 Death-1-treated Patients with Advanced Melanoma Treated with a <i>BRAF</i>
 Therapy in the Index Line or Prior to Index</b>
 <b>Supplemental
 Table 2. Baseline Demographic Characteristics for Patients with Advanced
 Melanoma, Died on Index, by <i>BRAF</i> Status</b><b></b>
 <b>Supplemental
 Table 3. Baseline Clinical Characteristics for Patients with Advanced
 Melanoma, Died on Index, by <i>BRAF</i> Status</b>
 <b>Supplemental
 Table 4. Treatment Characteristics in Baseline, Died on Index, by <i>BRAF</i>
 Status</b>
 <b>Supplemental
 Table 5. <i>BRAF</i>mt and <i>BRAF</i>wt Overall Survival from the Index
 Date, Stratified by Receipt of Index Anti-PD-1 After Progression</b>
DOI: 10.5281/zenodo.8081648
title: Data package

description: Here we report the full dataset used for the manuscript 'Tracing the Scale of Fluid Flow in Subduction Zone Forearcs: Implications from Fluid-Mobile Elements' submitted to the journal Chemical Geology. The reader is referred to the Methods section for a detailed description of the analytical protocols.

Contents of the file

Table A.1. Sample locations, pressure-temperature estimates based on Raman Spectroscopy of Carbonaceous Material and multi-phase equilibrium model, and salinity of fluid inclusions in vein samples.

Table A.2. Whole-rock major and trace element composition of metapelites from the Kodiak Complex and the Shimanto Belt, as well as values of duplicates, blank, and standards.

Table A.3. LA-ICP-MS analyses of reference material used for calibration and to monitor the data quality.

Table A.4. Trace element concentrations in illite (ill), albite (ab), chlorite (chl), and vein calcite (Cc) determined by LA-ICP-MS.

Table A.5. Chemical composition of fluid inclusions analyzed by LA-ICP-MS and semi-quantified by the charge-balance approach.

Figure A.1. Transient LA-ICP-MS signals of analyzed elements in FI-poor and FI-rich areas of quartz.
DOI: 10.5281/zenodo.8081649
title: Data package

description: Here we report the full dataset used for the manuscript Fluid Circulation in Subducted Sediments at the Base of the Seismogenic Zone: Closed vs. Open System Behavior submitted to Geochimica et Cosmocimica Acta. The dataset includes all data that appear in both the main manuscript and as supplements. The reader is referred to the Methods section for a detailed description of the analytical protocols.


Contents of the file


Table 1. Whole-rock trace element composition of studied metapelites from the Shimanto Belt and the Kodiak accretionary complex. RSCM, K2O and MgO results.


Table 2. The average concentrations and standard deviation of trace elements in chlorite (chl), illite (ill), albite (ab), and calcite (cc) analyzed by LA-ICP-MS.


Table 3. Average values and standard deviation of recovered concentrations of major, minor and trace elements in fluid inclusion populations and molar ratios for each studied formation. Thus, we report only point analyses where Ca was successfully measured.


Table S1. Sample locations, pressure-temperature estimates based on Raman Spectroscopy of Carbonaceous Material and multi-phase equilibrium model, and salinity of fluid inclusions in vein samples. Literature: 1Rajič et al. (2023); 2Palazzin et al. (2016); 3Raimbourg et al. (2018); 4Raimbourg et al. (2021).


Table S2. Trace element concentrations in illite (ill), albite (ab), chlorite (chl), and vein calcite (Cc) determined by LA-ICP-MS.


Table S3. Chemical composition of fluid inclusions analyzed by LA-ICP-MS and semi-quantified by the charge-balance approach. B.d.l. - below detection limit; n.m. - not measured.
DOI: 10.25549/hunn-ouc1sto1649654
title: Rubel Castle
DOI: 10.6084/m9.figshare.14920860.v1
title: Additional file 2 of Luteal phase support for in vitro fertilization/intracytoplasmic sperm injection fresh cycles: a systematic review and network meta-analysis

description: Additional file 2: Figure S1. Risk of bias presented as percentages across all included studies. Figure S2. Summary of risk of bias for each trial. Figure S3. Network meta-analysis (NMA) of clinical pregnancy and miscarriage according to luteal phase support initiation strategy. Abbreviations: HCG=human chorionic gonadotrophin; VPP=vaginal progesterone pessary; VPG=vaginal progesterone gel; IMP=intramuscular progesterone; OP=oral progesterone; RP=rectal progesterone. Figure S4. Global and local inconsistency tests between direct and indirect estimates in the analyses of the pregnancy outcomes. Blue alphabets represent early luteal phase supports. Yellow alphabets represent delayed luteal phase supports. A=placebo; B=human chorionic gonadotrophin; C=vaginal progesterone pessary; D=vaginal progesterone gel; E=intramuscular progesterone; F=oral progesterone; G=rectal progesterone. Figure S5. Network meta-analysis (NMA) for clinical pregnancy and miscarriage. Figure S6. The effects of adding oestrogen, HCG or GnRH agonists in the luteal phase on the pregnancy outcomes. Abbreviations: GnRH, gonadotropin releasing hormone; HCG, human chorionic gonadotrophin. Figure S7. The effects of luteal phase support on adverse events. Figure S8. Global and local inconsistency tests between direct and indirect estimates in the analyses of the pregnancy outcomes (regardless of the initiations of luteal phase supports). A=placebo; B=human chorionic gonadotrophin; C=vaginal progesterone pessary; D=vaginal progesterone gel; E=intramuscular progesterone; F=oral progesterone; G=rectal progesterone; H=vaginal progesterone pessary+ oestrogen; J=intramuscular progesterone+ oestrogen; K= vaginal progesterone pessary + human chorionic gonadotrophin; L=intramuscular progesterone+ human chorionic gonadotrophin; N=subcutaneous progesterone; O=vaginal progesterone ring. Figure S9. Comparison-adjusted funnel plot for the pregnancy outcomes. Figure S10. Network meta-analysis (NMA) for ongoing pregnancy. (A) including studies since 2010, (B) including articles using long gonadotropin releasing hormone agonist protocol.
DOI: 10.25549/hunn-ouc1sto1649655
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649656
title: Rubel Castle
DOI: 10.6084/m9.figshare.14920863.v1
title: Additional file 3 of Luteal phase support for in vitro fertilization/intracytoplasmic sperm injection fresh cycles: a systematic review and network meta-analysis

description: Additional file 3: Table S1. Characteristics of the included studies in the systematic review. Abbreviations: NS, not stated; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; GnRH, gonadotropin releasing hormone; HCG, human chorionic gonadotrophin; FSH, follicle stimulating hormone; LH, luteinizing hormone; hMG, human menopausal gonadotropin; ET, embryo transfer; PD, pituitary desensitisation; SC, subcutaneous; IM, intramuscular; ART, assisted reproductive technology; BMI, body mass index; OHSS, ovarian hyperstimulation syndrome.
DOI: 10.25549/hunn-ouc1sto1649657
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649658
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649661
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649659
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649660
title: Dwayne Hunn Collection, 1966-2007
DOI: 10.6084/m9.figshare.14396589.v1
title: Additional file 2 of A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

description: Additional file 2.
DOI: 10.25549/hunn-ouc1sto1649662
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649674
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649663
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649664
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649665
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649676
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649678
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649666
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649667
title: Dwayne Hunn Collection, 1966-2007
DOI: 10.25549/hunn-ouc1sto1649677
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649675
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649668
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649669
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649670
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649671
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649672
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649673
title: Rubel Castle
DOI: 10.25549/hunn-ouc1sto1649679
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649680
title: Dwayne Hunn's Travels
DOI: 10.6084/m9.figshare.14936652
title: Additional file 3 of Identification and validation of lncRNAs involved in m6A regulation for patients with ovarian cancer

description: Additional file 3: Table S2. Difference in Immune microenvironment.
DOI: 10.25549/hunn-ouc1sto1649681
title: Dwayne Hunn's Travels
DOI: 10.25549/hunn-ouc1sto1649682
title: Dwayne Hunn's Travels
DOI: 10.6084/m9.figshare.14936646.v1
title: Additional file 1 of Identification and validation of lncRNAs involved in m6A regulation for patients with ovarian cancer

description: Additional file 1: Table S1. Trans-regulation lncRNA-TF-mRNA.
DOI: 10.25549/hunn-ouc1sto1649683
title: Dwayne Hunn's Travels
DOI: 10.6084/m9.figshare.21228156.v1
title: Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells

description: Using sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES), we established an <i>in vitro</i> model by poisoning cultured immortalized human bronchial epithelial cells. Nile Red staining revealed lipids accumulated 24 h after a toxic dose of CEES (0.9 mM). Lipidomics analysis showed most of the increased lipids were triglycerides (TGs), and the increase in TGs was further confirmed using a Triglyceride-Glo™ Assay kit. Protein and mRNA levels of DGAT1, an important TG biogenesis enzyme, were increased following 0.4 mM CEES exposure. Under higher dose CEES (0.9 mM) exposure, protein and mRNA levels of PPARγ coactivator-1ɑ (PGC-1ɑ), a well-known transcription factor that regulates fatty acid oxidation, were decreased. Finally, application with DGAT1 inhibitor A 922500 or PGC1ɑ agonist ZLN005 was able to block the CEES-induced TGs increase. Overall, our dissection of CEES-induced TGs accumulation provides new insight into energy metabolism dysfunction upon vesicant exposure.HIGHLIGHTSIn CEES (0.9 mM)-injured cells:Triglycerides (TGs) were abundant in the accumulated lipids.Expression of DGAT1, not DGAT2, was increased.Expression of PGC1ɑ, not PGC1β, was reduced.DGAT1 inhibitor or PGC1ɑ agonist blocked the CEES-mediated increase in TGs. In CEES (0.9 mM)-injured cells: Triglycerides (TGs) were abundant in the accumulated lipids. Expression of DGAT1, not DGAT2, was increased. Expression of PGC1ɑ, not PGC1β, was reduced. DGAT1 inhibitor or PGC1ɑ agonist blocked the CEES-mediated increase in TGs.
DOI: 10.25549/hunn-ouc112390637
title: "To Glendora via Bombay", 1967-01-15 [2 copies]

description: "To Glendora via Bombay." Glendora Press (1967 January 15). Article about Dwayne Hunn's journey from Cleveland, Ohio, to Glendora, California, via Bombay, India, to teach at Glendora High School. 2 copies.
DOI: 10.25549/hunn-ouc112390634
title: A little bit west of Saigon - OK

description: Article about The Safaris band using a photograph of the Bottle House with Michael Rubel, Dwayne Hunn, Rick Smart, and Ralph Kervian, Rubelia, Rubel Farms, Rubel Pharms, Glendora, California, USA.
DOI: 10.6084/m9.figshare.14396586
title: Additional file 1 of A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

description: Additional file 1.
DOI: 10.25549/hunn-ouc1sto1712056
title: Rubel Castle
DOI: 10.6084/m9.figshare.14396589
title: Additional file 2 of A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

description: Additional file 2.
DOI: 10.6084/m9.figshare.21228156
title: Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells

description: Using sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES), we established an <i>in vitro</i> model by poisoning cultured immortalized human bronchial epithelial cells. Nile Red staining revealed lipids accumulated 24 h after a toxic dose of CEES (0.9 mM). Lipidomics analysis showed most of the increased lipids were triglycerides (TGs), and the increase in TGs was further confirmed using a Triglyceride-Glo™ Assay kit. Protein and mRNA levels of DGAT1, an important TG biogenesis enzyme, were increased following 0.4 mM CEES exposure. Under higher dose CEES (0.9 mM) exposure, protein and mRNA levels of PPARγ coactivator-1ɑ (PGC-1ɑ), a well-known transcription factor that regulates fatty acid oxidation, were decreased. Finally, application with DGAT1 inhibitor A 922500 or PGC1ɑ agonist ZLN005 was able to block the CEES-induced TGs increase. Overall, our dissection of CEES-induced TGs accumulation provides new insight into energy metabolism dysfunction upon vesicant exposure.HIGHLIGHTSIn CEES (0.9 mM)-injured cells:Triglycerides (TGs) were abundant in the accumulated lipids.Expression of DGAT1, not DGAT2, was increased.Expression of PGC1ɑ, not PGC1β, was reduced.DGAT1 inhibitor or PGC1ɑ agonist blocked the CEES-mediated increase in TGs. In CEES (0.9 mM)-injured cells: Triglycerides (TGs) were abundant in the accumulated lipids. Expression of DGAT1, not DGAT2, was increased. Expression of PGC1ɑ, not PGC1β, was reduced. DGAT1 inhibitor or PGC1ɑ agonist blocked the CEES-mediated increase in TGs.
DOI: 10.6084/m9.figshare.14920803
title: Additional file 14 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

description: Additional file 14. Table S13