cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6272840.v1
title: Recent Advances and Perspectives in Cancer Drug Design

description: ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and antibody-small molecule conjugates have emerged as a worthwhile approach to improve drug selectivity and reduce adverse effects, which are the main challenges in cancer drug discovery. This review will examine the current panorama of drug research and development (R&D) with emphasis on some of the major advances brought to clinical trials and to the market in the past five years. Breakthrough discoveries will be highlighted along with the medicinal chemistry strategies used throughout the discovery process. In addition, this review will provide perspectives and updates on the discovery of novel molecular targets as well as drugs with innovative mechanisms of action.
DOI: 10.6084/m9.figshare.6272828
title: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosis of mediastinal lesions

description: ABSTRACT Objective To describe the results of endobronchial ultrasound-guided transbronchial needle aspiration in making diagnosis of mediastinal injuries associated to different causes. Methods A retrospective cross-sectional study of patients submitted to Endobronchial ultrasound-guided transbronchial needle aspiration at a private organization, between June 2013 and October 2016. All cases referred for collection of lymph nodes or peritracheal/peribronchial masses by endobronchial ultrasound-guided transbronchial needle aspiration, and evaluated through tomography or PET-CT were included. Interventional pulmonologists and thoracic surgeons with experience in the method did the procedures. Rapid on-site evaluation of fine needle aspiration was performed by an experienced pathologist. Material analysis included cytological smear and cytopathological analysis of paraffin-embedded cell blocks. Other specific analyses (immunocytochemistry, tests and cultures of infectious agents) were performed whenever necessary. Results We included 72 patients; 6 were excluded for presenting endobronchial lesions in which bronchoscopic biopsy could be performed, or intrathoracic lesions that were not accessible by endobronchial ultrasound-guided transbronchial needle aspiration. The mean age of 66 patients included for analysis was 61.17 years (±14.67 years), with a predominance of males (64%). Endobronchial ultrasound-guided transbronchial needle aspiration was definitive for diagnosis in 60 cases (91%). Three cases (4.5%) had inconclusive test results. There were no major complications related to the procedure. Conclusion Endobronchial ultrasound-guided transbronchial needle aspiration had a high diagnosis yield, with minimal morbidity, being an excellent option for diagnostic approach of patients with lymphadenopathy or intrathoracic lesions, and for neoplasm staging.
DOI: 10.6084/m9.figshare.6272828.v1
title: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosis of mediastinal lesions

description: ABSTRACT Objective To describe the results of endobronchial ultrasound-guided transbronchial needle aspiration in making diagnosis of mediastinal injuries associated to different causes. Methods A retrospective cross-sectional study of patients submitted to Endobronchial ultrasound-guided transbronchial needle aspiration at a private organization, between June 2013 and October 2016. All cases referred for collection of lymph nodes or peritracheal/peribronchial masses by endobronchial ultrasound-guided transbronchial needle aspiration, and evaluated through tomography or PET-CT were included. Interventional pulmonologists and thoracic surgeons with experience in the method did the procedures. Rapid on-site evaluation of fine needle aspiration was performed by an experienced pathologist. Material analysis included cytological smear and cytopathological analysis of paraffin-embedded cell blocks. Other specific analyses (immunocytochemistry, tests and cultures of infectious agents) were performed whenever necessary. Results We included 72 patients; 6 were excluded for presenting endobronchial lesions in which bronchoscopic biopsy could be performed, or intrathoracic lesions that were not accessible by endobronchial ultrasound-guided transbronchial needle aspiration. The mean age of 66 patients included for analysis was 61.17 years (±14.67 years), with a predominance of males (64%). Endobronchial ultrasound-guided transbronchial needle aspiration was definitive for diagnosis in 60 cases (91%). Three cases (4.5%) had inconclusive test results. There were no major complications related to the procedure. Conclusion Endobronchial ultrasound-guided transbronchial needle aspiration had a high diagnosis yield, with minimal morbidity, being an excellent option for diagnostic approach of patients with lymphadenopathy or intrathoracic lesions, and for neoplasm staging.
DOI: 10.6084/m9.figshare.6272825
title: Endovascular treatment of pseudoaneurysms secondary to chronic pancreatitis: reports of two cases

description: Abstract Pseudoaneurysm secondary to chronic pancreatitis is a rare complication, but one with a high mortality rate. It is etiologically associated with chronic pancreatitis, and most diagnoses are made after rupture, which manifests with clinical signs of acute hemorrhage. Computed tomography plays an important role in diagnosis, but digital subtraction angiography remains the gold-standard method for diagnostic confirmation and for treatment planning. This article describes two cases of pseudoaneurysm in patients with chronic alcoholic pancreatitis; one involving the splenic artery and the other the gastroduodenal artery, complicated by thoracic and abdominal bleeding respectively. Both were successfully treated, using minimally invasive endovascular methods to implant coils and stent-grafts.
DOI: 10.6084/m9.figshare.6272825.v1
title: Endovascular treatment of pseudoaneurysms secondary to chronic pancreatitis: reports of two cases

description: Abstract Pseudoaneurysm secondary to chronic pancreatitis is a rare complication, but one with a high mortality rate. It is etiologically associated with chronic pancreatitis, and most diagnoses are made after rupture, which manifests with clinical signs of acute hemorrhage. Computed tomography plays an important role in diagnosis, but digital subtraction angiography remains the gold-standard method for diagnostic confirmation and for treatment planning. This article describes two cases of pseudoaneurysm in patients with chronic alcoholic pancreatitis; one involving the splenic artery and the other the gastroduodenal artery, complicated by thoracic and abdominal bleeding respectively. Both were successfully treated, using minimally invasive endovascular methods to implant coils and stent-grafts.
DOI: 10.6084/m9.figshare.6272798
title: Compressibility and water availability in Albaqualf soils under different deployment times in no-tillage

description: ABSTRACT: The southern Brazilian lowlands have been historically used for flooded rice cultivation. Over time, heavy machinery and intensive tillage practices have resulted in soil structure disruption, soil compaction, higher production costs and lower agricultural profitability. This study aimed to evaluate the effect of different deployment times of no-tillage (NT). Soil properties including bulk density (BD), compression index (CI), preconsolidation pressure (σp), bulk density at preconsolidation pressure (BDσp), degree of compactness (DC), soil water retention curve (SWRC), plant available water (PAW) and total organic carbon (TOC) content were evaluated using a 30-yr non-cultivated field (NC), adjacent to the experimental plots as a control. The BD, σp, BDσp and DC decreased in response to NT adoption time while the soil water holding capacity increased, allowing for higher PAW. Results from this study demonstrated the positive effects of NT on the overall quality of soils.
DOI: 10.6084/m9.figshare.6272798.v1
title: Compressibility and water availability in Albaqualf soils under different deployment times in no-tillage

description: ABSTRACT: The southern Brazilian lowlands have been historically used for flooded rice cultivation. Over time, heavy machinery and intensive tillage practices have resulted in soil structure disruption, soil compaction, higher production costs and lower agricultural profitability. This study aimed to evaluate the effect of different deployment times of no-tillage (NT). Soil properties including bulk density (BD), compression index (CI), preconsolidation pressure (σp), bulk density at preconsolidation pressure (BDσp), degree of compactness (DC), soil water retention curve (SWRC), plant available water (PAW) and total organic carbon (TOC) content were evaluated using a 30-yr non-cultivated field (NC), adjacent to the experimental plots as a control. The BD, σp, BDσp and DC decreased in response to NT adoption time while the soil water holding capacity increased, allowing for higher PAW. Results from this study demonstrated the positive effects of NT on the overall quality of soils.
DOI: 10.6084/m9.figshare.6272792
title: Characteristics of the fruits of two uvaia populations grown in Salesópolis, SP, Brazil

description: Abstract Uvaia (Eugenia pyriformis Cambess) is a fruit tree native to the Atlantic Forest and that features peculiar aroma and flavor. Although this fruit is highly popular locally, its commercial farming is virtually nonexistent. In addition, limited studies on this fruit have been conducted. Therefore, the present study aimed to investigate the physical, chemical, and functional characteristics of two uvaia fruit populations grown in Salesópolis, SP, Brazil, in order to determine their potential for being consumed both in natura and processed. Uvaia fruits were evaluated as for skin color, whole fruit weight, longitudinal and transversal diameters, seed percentage, pulp yield, pulp firmness, pH, total soluble solids (TSS), total titratable acidity (TTA), TSS/TTA ratio, total soluble sugars, soluble and total pectins, total carotenoids, yellow flavonoids, total phenolic compounds, ascorbic acid, and in vitro antioxidant capacity (DPPH and ORAC assays). The total mineral content was also determined. Comparison among the two populations revealed that uvaia fruits showed significantly different firmness values, large fruits showing suitable characteristics for the fresh fruit market. However, small fruits were sweeter and richer in antioxidants, allowing the consumption of both natural and processed fruits. Thus, this native fruit denotes an important source of nutrients and bioactive compounds, especially iron.
DOI: 10.6084/m9.figshare.6272789
title: Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

description: BACKGROUND The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes. OBJECTIVES We evaluated the association of 13 cytokine-related genes (TGFB: rs8179181, rs8105161, rs1800469; IL10: rs1800890, rs1800871, rs1800896; IFNG: rs2430561; TNF: rs1800629; BAT1: rs3853601; LTA: rs909253, rs2239704; TNFR1: rs767455; TNFR2: rs1061624) with risk and progression of CCC. FINDINGS Four hundred and six seropositive patients from CD endemic areas in the state of Pernambuco, north-eastern Brazil, were classified as non-cardiopathic (A, 110) or cardiopathic (mild, B1, 163; severe, C, 133). We found no evidence of TGFB, IL10, TNF, or TNFR1/2 gene polymorphisms associated with CCC risk or progression. Only BAT1 rs3853601 −22G carriers (B1 vs. C: OR = 0.5; p-value = 0.03) and IFNG rs2430561 +874AT (A vs. C: OR = 0.7; p-value = 0.03; A vs. B1+C: OR = 0.8; p-value = 0.02) showed a significant association with protection from cardiopathy in a logistic regression analysis with adjustment for gender and ethnicity; however, the association disappeared after performing adjustment for multiple testing. A systematic review of TNF rs1800629 −308G&gt;A publications included five studies for meta-analysis (534 CCC and 472 asymptomatic patients) and showed no consensus in pooled odds ratio (OR) estimates for A allele or A carriers (OR = 1.4 and 1.5; p-values = 0.14 and 0.15, respectively). In CD patients, TNF serum levels were increased, but not affected by the TNF rs1800629 −308A allele. MAIN CONCLUSIONS Our data suggest no significant contribution of the analysed gene variants of cytokine-related molecules to development/severity of Chagas' heart disease, reinforcing the idea that parasite/host interplay is critical to CD outcomes.
DOI: 10.6084/m9.figshare.6272792.v1
title: Characteristics of the fruits of two uvaia populations grown in Salesópolis, SP, Brazil

description: Abstract Uvaia (Eugenia pyriformis Cambess) is a fruit tree native to the Atlantic Forest and that features peculiar aroma and flavor. Although this fruit is highly popular locally, its commercial farming is virtually nonexistent. In addition, limited studies on this fruit have been conducted. Therefore, the present study aimed to investigate the physical, chemical, and functional characteristics of two uvaia fruit populations grown in Salesópolis, SP, Brazil, in order to determine their potential for being consumed both in natura and processed. Uvaia fruits were evaluated as for skin color, whole fruit weight, longitudinal and transversal diameters, seed percentage, pulp yield, pulp firmness, pH, total soluble solids (TSS), total titratable acidity (TTA), TSS/TTA ratio, total soluble sugars, soluble and total pectins, total carotenoids, yellow flavonoids, total phenolic compounds, ascorbic acid, and in vitro antioxidant capacity (DPPH and ORAC assays). The total mineral content was also determined. Comparison among the two populations revealed that uvaia fruits showed significantly different firmness values, large fruits showing suitable characteristics for the fresh fruit market. However, small fruits were sweeter and richer in antioxidants, allowing the consumption of both natural and processed fruits. Thus, this native fruit denotes an important source of nutrients and bioactive compounds, especially iron.
DOI: 10.6084/m9.figshare.6272789.v1
title: Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

description: BACKGROUND The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes. OBJECTIVES We evaluated the association of 13 cytokine-related genes (TGFB: rs8179181, rs8105161, rs1800469; IL10: rs1800890, rs1800871, rs1800896; IFNG: rs2430561; TNF: rs1800629; BAT1: rs3853601; LTA: rs909253, rs2239704; TNFR1: rs767455; TNFR2: rs1061624) with risk and progression of CCC. FINDINGS Four hundred and six seropositive patients from CD endemic areas in the state of Pernambuco, north-eastern Brazil, were classified as non-cardiopathic (A, 110) or cardiopathic (mild, B1, 163; severe, C, 133). We found no evidence of TGFB, IL10, TNF, or TNFR1/2 gene polymorphisms associated with CCC risk or progression. Only BAT1 rs3853601 −22G carriers (B1 vs. C: OR = 0.5; p-value = 0.03) and IFNG rs2430561 +874AT (A vs. C: OR = 0.7; p-value = 0.03; A vs. B1+C: OR = 0.8; p-value = 0.02) showed a significant association with protection from cardiopathy in a logistic regression analysis with adjustment for gender and ethnicity; however, the association disappeared after performing adjustment for multiple testing. A systematic review of TNF rs1800629 −308G&gt;A publications included five studies for meta-analysis (534 CCC and 472 asymptomatic patients) and showed no consensus in pooled odds ratio (OR) estimates for A allele or A carriers (OR = 1.4 and 1.5; p-values = 0.14 and 0.15, respectively). In CD patients, TNF serum levels were increased, but not affected by the TNF rs1800629 −308A allele. MAIN CONCLUSIONS Our data suggest no significant contribution of the analysed gene variants of cytokine-related molecules to development/severity of Chagas' heart disease, reinforcing the idea that parasite/host interplay is critical to CD outcomes.
DOI: 10.6084/m9.figshare.6272786
title: Synthesis and Characterization of Niobium Carbide with Copper Addition Obtained Via Gas Solid Reaction

description: The use of niobium containing materials' has gained much attention of the scientific community in the late years due its various applications in diverse fields. NbC is a highly versatile material. Copper addition may alter several of its properties, such as morphology, crystal structure etc. as well as enhance its catalytic behavior. Nanostructured NbC with copper addition synthesis' presented here had the precursor [(NH4)3[NbO(C2O4)3]xH2O] as starting material, which was doped with Cu(NO3)2 at 5% and 10% (molar) ratios. Doped NbC was obtained via gas solid reaction in fixed bed reactor at lower temperature (980°C) and with shorter reaction time (2h) than traditional methods. Reaction products' were characterized by XRD, crystal sizes were estimated according to HWL method, and SEM, XRF, BET and laser particle size analysis were performed. XRD indicated the formation of NbC and Cu phases with cubic crystal structure of ~20nm. SEM showed slight morphological change upon increasing copper content, indicating a less porous structure, which is consistent with BET data (43.7m2/g for 5%Cu-NbC and 37m 2/g for the 10% Cu-NbC). Crystal size calculations showed that increasing dopant content particle sizes were also increased, probably due to the presence of the dopant, in some extent, in the crystal structure.
DOI: 10.6084/m9.figshare.6272786.v1
title: Synthesis and Characterization of Niobium Carbide with Copper Addition Obtained Via Gas Solid Reaction

description: The use of niobium containing materials' has gained much attention of the scientific community in the late years due its various applications in diverse fields. NbC is a highly versatile material. Copper addition may alter several of its properties, such as morphology, crystal structure etc. as well as enhance its catalytic behavior. Nanostructured NbC with copper addition synthesis' presented here had the precursor [(NH4)3[NbO(C2O4)3]xH2O] as starting material, which was doped with Cu(NO3)2 at 5% and 10% (molar) ratios. Doped NbC was obtained via gas solid reaction in fixed bed reactor at lower temperature (980°C) and with shorter reaction time (2h) than traditional methods. Reaction products' were characterized by XRD, crystal sizes were estimated according to HWL method, and SEM, XRF, BET and laser particle size analysis were performed. XRD indicated the formation of NbC and Cu phases with cubic crystal structure of ~20nm. SEM showed slight morphological change upon increasing copper content, indicating a less porous structure, which is consistent with BET data (43.7m2/g for 5%Cu-NbC and 37m 2/g for the 10% Cu-NbC). Crystal size calculations showed that increasing dopant content particle sizes were also increased, probably due to the presence of the dopant, in some extent, in the crystal structure.
DOI: 10.6084/m9.figshare.6272780
title: Experimental Investigation of Ternary Al-Si-Cu Alloy Solidified with Unsteady-State Heat Flow Conditions

description: Ternary Al-9.0wt%Si-4.0wt%Cu alloy was solidified in a vertical directional solidification system under unsteady-state heat flow conditions. The resulting dendritic morphology and microsegregation were investigated. A more detailed analysis was dedicated to the microsegregation phenomena where a multielement interaction was observed. The solidification parameters such as: solidification speed (VL) and cooling rate ( T ˙) were determined from the cooling curves obtained during the solidification process. The thermal variables effect on the dendritic morphology is presented. The measurements of tertiary dendrite arm spacing (λ3) and microsegregation were performed for different positions along the casting. The experimental curves for microsegregation were obtained for Si and Cu from the center of dendritic tertiary arm to the next nearest tertiary arm. The solidification speed (VL) influence is "built into" the effective partition coefficient (Kef_Cu and Kef_Si) that has been determined for the range of VL and microsegregation curves are calculated by Scheil's equation for comparison with experimental data. Good agreements of the Scheil's equation with experimental data on microsegregation curves of the Si and Cuwere obtained when effective partition coefficient (Kef_Cu and Kef_Si) is taken into consideration. The multielement interaction effect on the Si microsegregation is investigated. Experimental results show that, Cu-rich dendrites were accompanied by minute amounts of Si. The concentration profiles obtained experimentally point to a strong negative correlation between Si and VL on ternary Al-9.0wt%Si-4.0wt%Cu alloy.