cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2x34wf4
title: BindingDB Entry 50001228: Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics.

description: Small molecule binding data for protein Nociceptin/mu opioid receptor, Uniprot P33535
DOI: 10.7270/q2x63m6b
title: BindingDB Entry 50010307: Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines.

description: Small molecule binding data for protein Neurokinin 1 receptor and Neurokinin 2 receptor, Uniprot P21452 and P25103
DOI: 10.7270/q20001bh
title: BindingDB Entry 50010349: Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor.

description: Small molecule binding data for protein Bradykinin B2 receptor, Uniprot P30411
DOI: 10.7270/q2057f0c
title: BindingDB Entry 50005873: A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies.

description: Small molecule binding data for protein Human immunodeficiency virus type 1 protease
DOI: 10.7270/q20v8br8
title: BindingDB Entry 50001243: Inhibitors of human renin. Cyclic peptide analogues containing a D-Phe-Lys-D-Trp sequence.

description: Small molecule binding data for protein Renin, Uniprot P00797 and P08424
DOI: 10.7270/q20z72jx
title: BindingDB Entry 50010321: Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors.

description: Small molecule binding data for protein Melatonin receptor, Uniprot P48039 and P49286
DOI: 10.7270/q22v2f8k
title: BindingDB Entry 50008202: C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.

description: Small molecule binding data for protein Mammalian target of Rapamycin (mTORC1), Uniprot P62942
DOI: 10.7270/q23n22cm
title: BindingDB Entry 50001275: Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid.

description: Small molecule binding data for protein Aromatase (CYP19) and Cytochrome P450 17A1, Uniprot P11511 and P11715
DOI: 10.7270/q23r0s4f
title: BindingDB Entry 50010346: 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.

description: Small molecule binding data for protein Alpha-chymotrypsin, Cathepsin G, Chymase, Leukocyte elastase, Plasmin, Prothrombin, and Trypsin-1, Uniprot P00734, P00766, P07477, P08246, P08311, P23946, and Q01177
DOI: 10.7270/q23x85px
title: BindingDB Entry 50005872: 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

description: Small molecule binding data for protein Dihydrofolate Reductase (DHFR), Dihydrofolate reductase, and Dihydrofolate reductase (DHFR), Uniprot P00374, P00381, P0ABQ4, P16184, Q07422, and Q920D2
DOI: 10.7270/q25m64vh
title: BindingDB Entry 50008217: Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.

description: Small molecule binding data for protein Voltage-gated calcium channel subunit alpha Cav2.2, Uniprot Q00975
DOI: 10.7270/q26m3609
title: BindingDB Entry 50008201: Stereoselective synthesis of a novel and bifunctional endothelin antagonist, IRL 3630.

description: Small molecule binding data for protein EDNRA and EDNRB, Uniprot P24530 and P25101
DOI: 10.7270/q27d2t4d
title: BindingDB Entry 50001259: 7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.

description: Small molecule binding data for protein Adenosine receptor A1, Uniprot P25099
DOI: 10.7270/q27h1hvr
title: BindingDB Entry 50010345: Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.

description: Small molecule binding data for protein Cathepsin G, Chymase, Chymotrypsin, Leukocyte elastase, Plasminogen, Prothrombin, and Trypsin, Uniprot P00734, P00747, P00760, P08246, P08311, P23946, and Q99895
DOI: 10.7270/q27p8xfq
title: BindingDB Entry 50005871: Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists.

description: Small molecule binding data for protein Platelet activating factor receptor, Uniprot P25105
DOI: 10.7270/q2bc3xq7
title: BindingDB Entry 50008200: Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity.

description: Small molecule binding data for protein EDNRA and EDNRB, Uniprot P24530 and P25101
DOI: 10.7270/q2bg2n1m
title: BindingDB Entry 50005896: Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist Leucettamine A and related analogues.

description: Small molecule binding data for protein LTB4R, Uniprot Q15722
DOI: 10.7270/q2c53jvq
title: BindingDB Entry 50001258: Imidazodiazepinediones: a new class of adenosine receptor antagonists.

description: Small molecule binding data for protein Adenosine receptor A1, Uniprot P25099
DOI: 10.7270/q2c828j1
title: BindingDB Entry 50010340: Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists.

description: Small molecule binding data for protein Neuropeptide Y receptor type 5 ( NPY Y5), Uniprot Q15761
DOI: 10.7270/q2cf9p5f
title: BindingDB Entry 50005861: Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.

description: Small molecule binding data for protein Phosphodiesterase 4A and cGMP-specific 3',5'-cyclic phosphodiesterase, Uniprot O76074
DOI: 10.7270/q2g1602g
title: BindingDB Entry 50010369: Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors.

description: Small molecule binding data for protein Cholinergic, muscarinic, Uniprot P06199
DOI: 10.7270/q2gx49jp
title: BindingDB Entry 50001254: Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.

description: Small molecule binding data for protein Serotonin (5-HT) receptor, Uniprot P19327
DOI: 10.7270/q2gx49t8
title: BindingDB Entry 50010331: The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.

description: Small molecule binding data for protein Aldehyde dehydrogenase (ALDH2), Uniprot P05091
DOI: 10.7270/q2h70dw9
title: BindingDB Entry 50005858: Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition.

description: Small molecule binding data for protein 5-lipoxygenase/FLAP and Arachidonate 5-lipoxygenase, Uniprot P09917
DOI: 10.7270/q2jw8d2f
title: BindingDB Entry 50008210: Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis.

description: Small molecule binding data for protein Mannose-6-phosphate isomerase, Uniprot P34948 and P34949
DOI: 10.7270/q2kw5f78
title: BindingDB Entry 50008197: Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.

description: Small molecule binding data for protein Cannabinoid receptor, Uniprot P20272
DOI: 10.7270/q2m044gn
title: BindingDB Entry 50005893: Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents.

description: Small molecule binding data for protein Acyl-CoA:cholesterol acyltransferase
DOI: 10.7270/q2mk6bvp
title: BindingDB Entry 50001252: Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.

description: Small molecule binding data for protein Arachidonate 5-lipoxygenase, Uniprot P12527
DOI: 10.7270/q2pn94t6
title: BindingDB Entry 50008206: Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.

description: Small molecule binding data for protein Sigma opioid receptor, Uniprot Q99720
DOI: 10.7270/q2qf8s4z
title: BindingDB Entry 50010362: Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position.

description: Small molecule binding data for protein Calpain small subunit 1 and Cathepsin (B and K), Uniprot P04574 and P07858
DOI: 10.7270/q2qr4w6p
title: BindingDB Entry 50005882: A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.

description: Small molecule binding data for protein Angiotensin II AT2 and Angiotensin II type 1a (AT-1a) receptor, Uniprot P34976 and P35351
DOI: 10.7270/q2rb73jz
title: BindingDB Entry 50001251: Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase).

description: Small molecule binding data for protein Glutamate carboxypeptidase II, Uniprot P70627
DOI: 10.7270/q2rf5t8b
title: BindingDB Entry 50010323: Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.

description: Small molecule binding data for protein 6-O-methylguanine-DNA methyltransferase, Uniprot P16455
DOI: 10.7270/q2td9wh3
title: BindingDB Entry 50008204: 4-[(1H-imidazol-4-yl) methyl] benzamidines and benzylamidines: novel antagonists of the histamine H3 receptor.

description: Small molecule binding data for protein HRH3, Uniprot Q9JI35
DOI: 10.7270/q2v69htt
title: BindingDB Entry 50010352: Multistep solution-phase parallel synthesis of spiperone analogues.

description: Small molecule binding data for protein Dopamine D2 receptor and serotonin 2a receptor, Uniprot P28223
DOI: 10.7270/q2vh5mwj
title: BindingDB Entry 50005880: Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.

description: Small molecule binding data for protein DRD2, Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor, Dopamine receptor, Dopamine receptors; D2 & D4, and OPIATE Sigma, Uniprot P20288, P21917, P35462, P61169, and Q9R0C9
DOI: 10.7270/q2w37v89
title: BindingDB Entry 50001247: Structure-based, C2 symmetric inhibitors of HIV protease.

description: Small molecule binding data for protein Human immunodeficiency virus type 1 protease
DOI: 10.7270/q2w66k1h
title: BindingDB Entry 50010322: Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors.

description: Small molecule binding data for protein Coagulation factor X/antithrombin III, Plasminogen, Prothrombin, Trypsin-1, and Vitamin K-dependent protein C, Uniprot P00734, P00742, P00747, P04070, and P07477
DOI: 10.7270/q2wd3zmm
title: BindingDB Entry 50005849: Novel Asp32-replacement tetrapeptide analogues as potent and selective CCK-A agonists.

description: Small molecule binding data for protein Cholecystokinin A receptor, Uniprot Q63931
DOI: 10.7270/q2z31xtn
title: BindingDB Entry 50008203: L-tryptophan urea amides as NK1/NK2 dual antagonists.

description: Small molecule binding data for protein Neurokinin 1 receptor and Neurokinin 2 receptor, Uniprot P21452 and P25103
DOI: 10.7270/q2zw1jwx
title: BindingDB Entry 50001276: Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.

description: Small molecule binding data for protein Dihydrofolate reductase and Thymidylate synthase, Uniprot P07607 and Q920D2
DOI: 10.7270/q21v5d46
title: BindingDB Entry 50008219: NMR and topochemical studies of peptidomimetic HIV-I protease inhibitors containing a cis-epoxide amide isostere.

description: Small molecule binding data for protein Human immunodeficiency virus type 1 protease
DOI: 10.7270/q22r3qw9
title: BindingDB Entry 50010378: Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids.

description: Small molecule binding data for protein EDNRA and EDNRB, Uniprot P21451 and P26684
DOI: 10.7270/q22z14m0
title: BindingDB Entry 50005900: A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists.

description: Small molecule binding data for protein Angiotensin II AT1B, Uniprot P29089
DOI: 10.7270/q24m93pp
title: BindingDB Entry 50008236: Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.

description: Small molecule binding data for protein Protein Farnesyltransferase (PFT), Uniprot P49354 and P49356
DOI: 10.7270/q26d5rz5
title: BindingDB Entry 50001321: Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.

description: Small molecule binding data for protein Beta-chymotrypsin, Cathepsin G, Elastase 1, and Leukocyte elastase, Uniprot P08246, P08311, and Q9UNI1
DOI: 10.7270/q26h4gng
title: BindingDB Entry 50010376: Arylacetamides as peripherally restricted kappa opioid receptor agonists.

description: Small molecule binding data for protein Kappa-type opioid receptor, Uniprot P41145
DOI: 10.7270/q26q1w9w
title: BindingDB Entry 50005897: Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.

description: Small molecule binding data for protein Adenosine receptor A1, Uniprot P25099
DOI: 10.7270/q29c6wkv
title: BindingDB Entry 50008213: Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics.

description: Small molecule binding data for protein Kallikrein-1 (KLK1), Prothrombin, Trypsin-1, and Tryptase, Uniprot P00734, P06870, P07477, Q15661,P20231, Q9BZJ3, and Q9NRR2
DOI: 10.7270/q29g5kvc
title: BindingDB Entry 50005921: Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.

description: Small molecule binding data for protein 12-Lipoxygenase (12-LOX), 5-lipoxygenase/FLAP, and Thromboxane-A synthase, Uniprot P09917, P18054, and P49430
DOI: 10.7270/q2b56hqb
title: BindingDB Entry 50001317: Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.

description: Small molecule binding data for protein HMG-CoA reductase, Uniprot P51639
DOI: 10.7270/q2b857c6
title: BindingDB Entry 50010374: N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.

description: Small molecule binding data for protein LDL-associated phospholipase A2, Uniprot Q13093
DOI: 10.7270/q2f47n9k
title: BindingDB Entry 50008211: Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array.

description: Small molecule binding data for protein Caspase-1, Uniprot P29466
DOI: 10.7270/q2fx78fr
title: BindingDB Entry 50001310: Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.

description: Small molecule binding data for protein AICAR transformylase, Dihydrofolate reductase, GAR transformylase, and Thymidylate Synthase (TS), Uniprot P00374, P00375, P00469, Q64737, and Q9CWJ9
DOI: 10.7270/q2g73crx
title: BindingDB Entry 50005895: Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships.

description: Small molecule binding data for protein LTB4R, Uniprot Q15722
DOI: 10.7270/q2hx1btv
title: BindingDB Entry 50008229: H-phosphonate derivatives as novel peptide deformylase inhibitors.

description: Small molecule binding data for protein Peptide Deformylase, Uniprot P0A6K3
DOI: 10.7270/q2k0739t
title: BindingDB Entry 50005911: Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.

description: Small molecule binding data for protein Thymidylate synthase, Uniprot P04818
DOI: 10.7270/q2kp8141
title: BindingDB Entry 50001296: Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors.

description: Small molecule binding data for protein Aromatase (CYP19), Uniprot P11511
DOI: 10.7270/q2kp81f2
title: BindingDB Entry 50010366: Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase.

description: Small molecule binding data for protein Bone morphogenetic protein 1, Uniprot P13497
DOI: 10.7270/q2np23k1
title: BindingDB Entry 50008227: Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.

description: Small molecule binding data for protein Adrenergic alpha1B, Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenergic receptor, and Serotonin (5-HT) receptor, Uniprot P15823, P19327, P23944, P25100, P35348, P35368, and P43140
DOI: 10.7270/q2pg1r04
title: BindingDB Entry 50010384: Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.

description: Small molecule binding data for protein AVPR1A, Vasopressin V1a receptor (V1a), Vasopressin V2 Receptor, and Vasopressin V2 receptor (V2), Uniprot P30518, P30560, P37288, and Q00788
DOI: 10.7270/q2pr7v1v
title: BindingDB Entry 50005910: 9-[(Phosphonoalkyl)benzyl]guanines. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.

description: Small molecule binding data for protein Purine nucleoside phosphorylase, Uniprot P00491
DOI: 10.7270/q2qc02g1
title: BindingDB Entry 50001278: Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.

description: Small molecule binding data for protein Thymidylate synthase, Uniprot P07607
DOI: 10.7270/q2sf2vbt
title: BindingDB Entry 50008226: Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin.

description: Small molecule binding data for protein Prothrombin, Uniprot P00734
DOI: 10.15468/dl.b1snzb
title: Occurrence Download

description: A dataset containing 11602 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Patterns of widespread decline in North American bumble bees",
 "TaxonKey is Bombus vosnesenskii Radoszkowski, 1862"
 ]
}

 The dataset includes 11602 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009602-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.d7469a
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "CoordinateUncertaintyInMeters 0.0-1090.0",
 "TaxonKey is Testudo horsfieldii Gray, 1844",
 "Year is greater than or equal to 2000"
 ]
}

 The dataset includes 15 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075303-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mdwxrx
title: Occurrence Download

description: A dataset containing 51 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ancylopsetta kumperae Tyler, 1959"
 ]
}

 The dataset includes 51 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0059620-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15156/bio/sh1032254.09fu
title: SH1032254.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1032255.09fu
title: SH1032255.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1032256.09fu
title: SH1032256.09FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.