cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5633767.v1
title: Supplementary Material for: Stress-Kinase Regulation of TASK-1 and TASK-3

description: <b><i>Background/Aims:</i></b> TASK channels belong to the two-pore-domain potassium (K<sub>2P</sub>) channel family. TASK-1 is discussed to contribute to chronic atrial fibrillation (AFib) and has been together with uncoupling protein 1 found as a marker protein of brown adipose tissue (BAT) fat. In addition, TASK-1 was linked in a genome-wide association study to an increased body mass index. A recent study showed that TASK-1 inhibition is causing obesity in mice by a BAT whitening and that these effects are linked to the mineralocorticoid receptor pathway, albeit the mechanism remained elusive. Therefore, we aimed to probe whether K<sub>2P</sub> channels are regulated by serum- and glucocorticoid-inducible kinases (SGKs) which are known to modify many cellular functions by modulating ion channels. <b><i>Methods:</i></b> To this end we used functional co-expression studies and chemiluminescence-assays in <i>Xenopus</i> oocytes, together with fluorescence imaging and quantitative PCR experiments. <b><i>Results:</i></b> SGKs and proteinkinase B (PKB) induced a strong, dose- and time-dependent current reduction of TASK-1 and TASK-3. SGK co-expression reduced the surface expression of TASK-1/3, leading to a predominant localization of the channels into late endosomes. The down regulation of TASK-3 channels was abrogated by the dynamin inhibitor dynasore, confirming a role of SGKs in TASK-1/3 channel endocytosis. <b><i>Conclusion:</i></b> Stress-mediated changes in SGK expression pattern or activation is likely to alter TASK-1/3 expression at the surface membrane. The observed TASK-1 regulation might contribute to the pathogenesis of chronic AFib and provide a mechanistic link between increased mineralocorticoid levels and TASK-1 reduction, both linked to BAT whitening.
DOI: 10.6084/m9.figshare.5633764
title: ProviderProfiling1

description: Simulation results used in "Investigating risk adjustment methods for health care provider profiling when observations are scarce or events rare"<br>R code can be found on: https://github.com/timobrakenhoff/ProviderProfiling1
DOI: 10.6084/m9.figshare.5633764.v1
title: ProviderProfiling1

description: Simulation results used in "Investigating risk adjustment methods for health care provider profiling when observations are scarce or events rare"<br>R code can be found on: https://github.com/timobrakenhoff/ProviderProfiling1
DOI: 10.6084/m9.figshare.5633755.v2
title: Involvement of programmed cell death in suppression of the number of root nodules formed in soybean induced by <i>Bradyrhizobium</i> infection

description: Legumes establish symbiosis with nitrogen-fixing rhizobia through root nodules to acquire nitrogen. Legumes control nodule number through systemic (autoregulation of nodulation) as well as local regulation. Moreover, plants defend themselves against bacteria and other pathogens through the induction of localized (localized acquired resistance) and systemic (SAR, systemic acquired resistance; ISR, induced systemic resistance) responses. Herein, we show that the number of root nodules is suppressed by programmed cell death (PCD), and is simultaneously controlled by SAR and ISR in soybean (<i>Glycine max</i> [L.] Merr.). The wild-type soybean cultivar Williams 82 showed markedly fewer root nodule primordia and PCD symptoms, including accelerated DNA degradation, enhanced generation of reactive oxygen species (visualized by 3,3′-diaminobenzidine staining), and excessive cell death (detected on staining with trypan blue) compared to the hypernodulation mutant NOD1-3. These results suggest that PCD suppresses the formation of root nodules in wild-type soybean. In addition, microarray and gene ontology analyses showed that essential components of hypersensitive response (HR) or disease resistance, such as resistance (R) genes, mitogen-activated protein kinase cascade, SAR, salicylic acid, jasmonic acid, ethylene, etc., were activated in wild-type plants. These analyses corroborate the above findings, demonstrating that the suppression of root nodule formation by PCD is accompanied by HR, and is simultaneously controlled by SAR and ISR in soybean. These findings provide new insight into the control of nodulation to balance nutritional requirements and energy status in legumes.
DOI: 10.5519/qd.9vaaynkd
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1264 records)
DOI: 10.6084/m9.figshare.5633734.v2
title: Cambrian (~510 Ma) ophiolites of the East Kunlun orogen, China: A case study from the Acite ophiolitic tectonic mélange

description: The Acite ophiolitic mélange represents a remnant of the Proto-Tethys forearc oceanic lithosphere. Two gabbros yield zircon <sup>206</sup>Pb/<sup>238</sup>U ages of 510-512 Ma. The magmatic rocks are divided into three subtypes: (1) Mid-ocean ridge basalt (MORB) -like forearc basalts (FABs), (2) Low-titanium tholeiitic gabbros (LTGs), and (3) Normal calc-alkaline dacites (CADs). The FABs have comparatively higher TiO<sub>2</sub> concentrations (1.13–1.42 wt%) and show almost flat REE patterns. In the NMORB normalized trace element patterns, the FABs display flat distributions of high field strength element (HFSE). The <i>ε</i><sub>Nd</sub>(t) values of FABs range from +4.0 to +4.8. These features are similar to the composition of Izu-Bonin-Mariana forearc basalts (FABs). LTGs are characterized by higher contents of MgO (8.85–9.95 wt%) and lower concentration of TiO<sub>2</sub>(0.29–0.50 wt%). They show LREE-depleted patterns, however having comparatively lower total REE contents than those of FABs. The <i>ε</i><sub>Nd</sub>(t) values of LTGs range from +7.4 to +8.4. These features show that LTG magmas originated from a progressively depleted mantle source. In contrast, the CADs having higher SiO<sub>2</sub> contents (63.58–70.92 wt%) have higher total REE contents. In the NMORB normalized trace element patterns, CADs are characterized by enrichment of LILEs and depletion of HFSEs. CADs have negative <i>ε</i><sub>Nd</sub>(t) values ranging from -9.8 to -10.5, which are likely suggestive of a crust-derived source. The rock association of FABs and LTGs, together with tectonic discrimination plots and regional data, suggest a forearc setting above the SSZ for Acite ophiolitic mélange.
DOI: 10.6084/m9.figshare.5633734.v1
title: Cambrian (~510 Ma) ophiolites of the East Kunlun orogen, China: A case study from the Acite ophiolitic tectonic mélange

description: The Acite ophiolitic mélange represents a remnant of the Proto-Tethys forearc oceanic lithosphere. Two gabbros yield zircon <sup>206</sup>Pb/<sup>238</sup>U ages of 510-512 Ma. The magmatic rocks are divided into three subtypes: (1) Mid-ocean ridge basalt (MORB) -like forearc basalts (FABs), (2) Low-titanium tholeiitic gabbros (LTGs), and (3) Normal calc-alkaline dacites (CADs). The FABs have comparatively higher TiO<sub>2</sub> concentrations (1.13–1.42 wt%) and show almost flat REE patterns. In the NMORB normalized trace element patterns, the FABs display flat distributions of high field strength element (HFSE). The <i>ε</i><sub>Nd</sub>(t) values of FABs range from +4.0 to +4.8. These features are similar to the composition of Izu-Bonin-Mariana forearc basalts (FABs). LTGs are characterized by higher contents of MgO (8.85–9.95 wt%) and lower concentration of TiO<sub>2</sub>(0.29–0.50 wt%). They show LREE-depleted patterns, however having comparatively lower total REE contents than those of FABs. The <i>ε</i><sub>Nd</sub>(t) values of LTGs range from +7.4 to +8.4. These features show that LTG magmas originated from a progressively depleted mantle source. In contrast, the CADs having higher SiO<sub>2</sub> contents (63.58–70.92 wt%) have higher total REE contents. In the NMORB normalized trace element patterns, CADs are characterized by enrichment of LILEs and depletion of HFSEs. CADs have negative <i>ε</i><sub>Nd</sub>(t) values ranging from -9.8 to -10.5, which are likely suggestive of a crust-derived source. The rock association of FABs and LTGs, together with tectonic discrimination plots and regional data, suggest a forearc setting above the SSZ for Acite ophiolitic mélange.
DOI: 10.6084/m9.figshare.5633638
title: MIST: A multi-resolution parcellation of functional networks

description: Functional brain connectomics investigates functional connectivity between distinct brain parcels. There is an increasing interest to investigate connectivity across several levels of spatial resolution, from networks down to localized areas. Here we present the Multiresolution Intrinsic Segmentation Template (MIST), a multi-resolution parcellation of the cortical, subcortical and cerebellar gray matter. We provide annotated functional parcellations at nine resolutions from 7 to 444 functional parcels. The MIST parcellations compare well with prior work in terms of homogeneity and generalizability. We found that parcels at higher resolutions largely fell within the boundaries of larger parcels at lower resolutions. This allowed us to provide an overlap based pseudo-hierarchical decomposition tree that relates parcels across resolutions in a meaningful way. We provide an interactive web interface to explore the MIST parcellations and also made it accessible in the neuroimaging library nilearn. We believe that the MIST parcellation will facilitate future investigations of the multiresolution basis of brain function.
DOI: 10.6084/m9.figshare.5633452
title: Pigmentation loss after injection of Cas9 or Cpf1 RNPs into zebrafish embryos.

description: Left side, diagram of experiment. 1-cell zebrafish embryos were injected with 1 nL of either Cas9 or Cpf1 injection mix targeting the tyrosinase gene (tyr). Cas9 injection mix was 10 uM SpCas9 protein (NEB), 150 pg sgRNAs (n=3, made using NEB EnGen sgRNA kit), 50 mM KCl, 2.5 mM MgCl2, 5 mM Tris pH 8, 0.01% phenol red. Cpf1 injection mix was 10 uM LbCpf1 protein (NEB), 150 pg crRNAs (n=3, from Synthego), 50 mM KCl, 2.5 mM MgCl2, 5 mM Tris pH 8, 0.01% phenol red. Injected embryos were grown at 28C. Survival rate was scored at 24 hours-post-fertilization (hpf); both injections had &gt;85% survival. Larvae were anesthetized at 72 hpf and scored for pigmentation. <br>Right side, images of representative uninjected, Cas9 injected and Cpf1 injected larvae, with phenotype scoring indicated in the lower right. <br>Sequences of the sgRNAs and crRNAs used:tyr_Cas9_sgRNA6 GGUGCGCCGGAAACUACAUGGUUUUAGAGCUAGAAAUAGCAAGUUAAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUtyr_Cas9_sgRNA9 GGUGUUGGCGAACAUUGGCGGUUUUAGAGCUAGAAAUAGCAAGUUAAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUtyr_Cas9_sgRNA10 GGGUGUACGAUUUAUUCGUGGUUUUAGAGCUAGAAAUAGCAAGUUAAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCUUUUtyr_Cpf1_crRNA1 UAAUUUCUACUAAGUGUAGAUCAACCAAACCUGCCAGUGCGCCGtyr_Cpf1_crRNA2 UAAUUUCUACUAAGUGUAGAUUUCGUGUGGAUGCAUUAUUACGUtyr_Cpf1_crRNA3 UAAUUUCUACUAAGUGUAGAUCGCAUGAGUCGGCGGCGUUUCUG<br>This experiment reproduces Figure 1f/g of this preprint:https://www.biorxiv.org/content/early/2017/06/26/156125
DOI: 10.17608/k6.auckland.5633440
title: Ninth Asia-Pacific Conference on Wind Engineering: Welcome and Programme

description: <b>Welcome </b><br>The Asia-Pacific Conferences on Wind Engineering (APCWE) are international events conducted every four years under the umbrella of the International Association for Wind Engineering (IAWE). They began with the First Asia-Pacific Symposium on Wind Engineering at Roorkee, India in 1985, and are held in the Asia-Pacific region mid-way between the four-yearly International Conferences on Wind Engineering. The APCWE conferences are international events regularly attended by 200 – 300 wind engineering researchers and practitioners from around the Asia-Pacific regions. <br><br>The previous conferences were held in Roorkee India, Beijing China, Hong Kong, Gold Coast Australia, Kyoto Japan, Seoul Korea, Taipei Taiwan, and Chennai India in 2013.<br><br>The Ninth Asia-Pacific Conference on Wind Engineering is being organised and hosted by the University of Auckland, Auckland, New Zealand. The University of Auckland is New Zealand’s pre-eminent research-led institution, and the Faculty of Engineering has been active in Wind Engineering research and testing since the 1970s. In 2015 it constructed a world-class Boundary Layer Wind Tunnel to further increase its capability in Wind Engineering research.<br><br>The Organising Committee is delighted to host APCWE-IX, and great efforts are being undertaken to ensure its success. We take pleasure in inviting academicians, engineers, scientists, technologists and architects to actively participate in the Ninth APCWE. APCWE-IX aims to provide a knowledge platform for exchanging state-of-the-art research findings and practical applications in all areas of wind engineering, and to further enhance international collaborations.<br><br>This Figshare site contains approximately 200 peer-reviewed submitted papers which were presented at the conference, as well as the Keynote papers and bios of the Keynote presenters. <br><br>The conference is being held in December when you can expect the weather to be warm and pleasant. We urge you to allow time to see some of our wonderful tourist sites and beaches while you are here.<br><br>Welcome to the APCWE-IX in Auckland, New Zealand.<br><br>Prof. Richard G.J. Flay<br>Chairman, APCWE-IX<br><br>
DOI: 10.17608/k6.auckland.5633440.v1
title: Ninth Asia-Pacific Conference on Wind Engineering: Welcome and Programme

description: <b>Welcome </b><br>The Asia-Pacific Conferences on Wind Engineering (APCWE) are international events conducted every four years under the umbrella of the International Association for Wind Engineering (IAWE). They began with the First Asia-Pacific Symposium on Wind Engineering at Roorkee, India in 1985, and are held in the Asia-Pacific region mid-way between the four-yearly International Conferences on Wind Engineering. The APCWE conferences are international events regularly attended by 200 – 300 wind engineering researchers and practitioners from around the Asia-Pacific regions. <br><br>The previous conferences were held in Roorkee India, Beijing China, Hong Kong, Gold Coast Australia, Kyoto Japan, Seoul Korea, Taipei Taiwan, and Chennai India in 2013.<br><br>The Ninth Asia-Pacific Conference on Wind Engineering is being organised and hosted by the University of Auckland, Auckland, New Zealand. The University of Auckland is New Zealand’s pre-eminent research-led institution, and the Faculty of Engineering has been active in Wind Engineering research and testing since the 1970s. In 2015 it constructed a world-class Boundary Layer Wind Tunnel to further increase its capability in Wind Engineering research.<br><br>The Organising Committee is delighted to host APCWE-IX, and great efforts are being undertaken to ensure its success. We take pleasure in inviting academicians, engineers, scientists, technologists and architects to actively participate in the Ninth APCWE. APCWE-IX aims to provide a knowledge platform for exchanging state-of-the-art research findings and practical applications in all areas of wind engineering, and to further enhance international collaborations.<br><br>This Figshare site contains approximately 200 peer-reviewed submitted papers which were presented at the conference, as well as the Keynote papers and bios of the Keynote presenters. <br><br>The conference is being held in December when you can expect the weather to be warm and pleasant. We urge you to allow time to see some of our wonderful tourist sites and beaches while you are here.<br><br>Welcome to the APCWE-IX in Auckland, New Zealand.<br><br>Prof. Richard G.J. Flay<br>Chairman, APCWE-IX<br><br>
DOI: 10.17608/k6.auckland.5633440.v4
title: Ninth Asia-Pacific Conference on Wind Engineering: Welcome

description: <b>Welcome </b><br>The Asia-Pacific Conferences on Wind Engineering (APCWE) are international events conducted every four years under the umbrella of the International Association for Wind Engineering (IAWE). They began with the First Asia-Pacific Symposium on Wind Engineering at Roorkee, India in 1985, and are held in the Asia-Pacific region mid-way between the four-yearly International Conferences on Wind Engineering. The APCWE conferences are international events regularly attended by 200 – 300 wind engineering researchers and practitioners from around the Asia-Pacific regions. <br><br>The previous conferences were held in Roorkee India, Beijing China, Hong Kong, Gold Coast Australia, Kyoto Japan, Seoul Korea, Taipei Taiwan, and Chennai India in 2013.<br><br>The Ninth Asia-Pacific Conference on Wind Engineering is being organised and hosted by the University of Auckland, Auckland, New Zealand. The University of Auckland is New Zealand’s pre-eminent research-led institution, and the Faculty of Engineering has been active in Wind Engineering research and testing since the 1970s. In 2015 it constructed a world-class Boundary Layer Wind Tunnel to further increase its capability in Wind Engineering research.<br><br>The Organising Committee is delighted to host APCWE-IX, and great efforts are being undertaken to ensure its success. We take pleasure in inviting academicians, engineers, scientists, technologists and architects to actively participate in the Ninth APCWE. APCWE-IX aims to provide a knowledge platform for exchanging state-of-the-art research findings and practical applications in all areas of wind engineering, and to further enhance international collaborations.<br><br>This Figshare site contains approximately 200 peer-reviewed submitted papers which were presented at the conference, as well as the Keynote papers and bios of the Keynote presenters. <br><br>The conference is being held in December when you can expect the weather to be warm and pleasant. We urge you to allow time to see some of our wonderful tourist sites and beaches while you are here.<br><br>Welcome to the APCWE-IX in Auckland, New Zealand.<br><br>Prof. Richard G.J. Flay<br>Chairman, APCWE-IX<br><br>
DOI: 10.6084/m9.figshare.5633425
title: A Predictive Spatial Distribution Framework for Filovirus-Infected Fruit Bats

description: Simulation code (MPI_2017_07_26.zip) and data sets (SpatialDistrModel_k0_Guinea_inputMaps.zip) for the SIR model about filovirus infection dynamics in bats populations. The README file contains information and instruction for compilation.
DOI: 10.6084/m9.figshare.5633425.v2
title: A Predictive Spatial Distribution Framework for Filovirus-Infected Fruit Bats

description: Simulation code (MPI_2017_07_26.zip) and data sets (SpatialDistrModel_k0_Guinea_inputMaps.zip) for the SIR model about filovirus infection dynamics in bats populations. The README file contains information and instruction for compilation.
DOI: 10.6084/m9.figshare.5633398
title: whopop.dta

description: This Stata dataset contains the WHO standardized population data that was utilized for age adjustment in the study. These same data can be found in sheet two of the excel file titled "csicrp_metabolic"
DOI: 10.6084/m9.figshare.5633398.v1
title: whopop.dta

description: This Stata dataset contains the WHO standardized population data that was utilized for age adjustment in the study. These same data can be found in sheet two of the excel file titled "csicrp_metabolic"
DOI: 10.6084/m9.figshare.5633392
title: csicrp_metabolic.dta

description: This Stata dataset contains the deidentified raw data utilized in our analysis. These same data can be found in sheet 1 of the excel file titled "csicrp_metabolic"
DOI: 10.6084/m9.figshare.5633392.v1
title: csicrp_metabolic.dta

description: This Stata dataset contains the deidentified raw data utilized in our analysis. These same data can be found in sheet 1 of the excel file titled "csicrp_metabolic"
DOI: 10.6084/m9.figshare.5633386
title: csicrp_metabolic.xls

description: This excel file contains the raw data used in the study. These same data are provided in the identically named stata .dta file
DOI: 10.6084/m9.figshare.5633386.v1
title: csicrp_metabolic.xls

description: This excel file contains the raw data used in the study. These same data are provided in the identically named stata .dta file
DOI: 10.6084/m9.figshare.5633347
title: Merged anvi'o profiles for DWH O. desum

description: This archive contains the anvi'o contigs database and the merged anvi'o profile that shows the read recruitment by DWH O. desum from three oil spill metagenomes.
DOI: 10.6084/m9.figshare.5633347.v1
title: Merged anvi'o profiles for DWH O. desum

description: This archive contains the anvi'o contigs database and the merged anvi'o profile that shows the read recruitment by DWH O. desum from three oil spill metagenomes.
DOI: 10.6084/m9.figshare.5633344
title: DWH O. desum

description: FASTA File for the population genome DWH O. desum
DOI: 10.6084/m9.figshare.5633344.v1
title: DWH O. desum

description: FASTA File for the population genome DWH O. desum
DOI: 10.6084/m9.figshare.5633335
title: Warming reduces the cover, richness and evenness of lichen-dominated biocrusts but promotes moss growth: Insights from an eight-year experiment

description: Richness, diversity, evenness, cover, relative abundance and species presence databases of a biocrust community subjected to a simulated climate change experiment.
DOI: 10.6084/m9.figshare.5633335.v1
title: Warming reduces the cover, richness and evenness of lichen-dominated biocrusts but promotes moss growth: Insights from an eight-year experiment

description: Richness, diversity, evenness, cover, relative abundance and species presence databases of a biocrust community subjected to a simulated climate change experiment.
DOI: 10.6084/m9.figshare.5633329
title: Simulation Dataset

description: Raw data used to generate the figures and information used on paper "Countering Protection Rackets using Legal and Social Approaches: An Agent-Based Test"
DOI: 10.6084/m9.figshare.5633323
title: Figures

description: Figures<br>
DOI: 10.6084/m9.figshare.5633320
title: Source Code and Scripts

description: Source-code, configuration files and scripts to generate the dataset<br>
DOI: 10.6084/m9.figshare.5633299.v2
title: PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

description: Damaged or dysfunctional mitochondria are toxic to the cell by producing reactive oxygen species and releasing cell death factors. Therefore, timely removal of these organelles is critical to cellular homeostasis and viability. Mitophagy is the mechanism of selective degradation of mitochondria via autophagy. The significance of mitophagy in kidney diseases, including ischemic acute kidney injury (AKI), has yet to be established, and the involved pathway of mitophagy remains poorly understood. Here, we show that mitophagy is induced in renal proximal tubular cells in both in vitro and in vivo models of ischemic AKI. Mitophagy under these conditions is abrogated by <i>Pink1</i> and <i>Park2</i> deficiency, supporting a critical role of the PINK1-PARK2 pathway in tubular cell mitophagy. Moreover, ischemic AKI is aggravated in <i>pink1</i> and<i>park2</i> single- as well as double-knockout mice. Mechanistically, <i>Pink1</i> and <i>Park2</i> deficiency enhances mitochondrial damage, reactive oxygen species production, and inflammatory response. Taken together, these results indicate that PINK1-PARK2-mediated mitophagy plays an important role in mitochondrial quality control, tubular cell survival, and renal function during AKI.