DOI: 10.7910/dvn/avaogp
title: Pediatric HIV/AIDS Cohort Study (PHACS) PH205 Cardiac Toxicity Substudy

description: The Cardiac Toxicity Substudy (PH205) enrolled 158 participants who completed an echocardiogram ~10 years ago while participating in the PHACS Adolescent Master Protocol (AMP) and who were later enrolled in the PHACS AMP Up study (for participants 18 years of age and older). Participants had a follow up echocardiogram, measurement of aortic pulse wave velocity (PWV), and samples obtained for measurement of cardiac and inflammatory biomarkers and mitochondrial parameters. The primary outcomes were changes in cardiac function and structure as reflected by differences in key echocardiogram z-scores (for ejection fraction, left ventricular (LV) mass and volume, end diastolic dimension, etc).&lt;br&gt;&lt;br&gt;

At the most recent echocardiogram, the data collected included echocardiogram measures, pulse wave velocity (PWV), cardiac and inflammatory biomarkers, and mitochondrial parameters. Measures of HIV infection status (PHIV or PHEU) and HIV disease status nearest the echo are also included.&lt;br&gt;&lt;br&gt;

Similar measures were collected at the earlier echocardiogram, with the exception of PWV and mitochondrial parameters, which were not obtained at the earlier timepoint.&lt;br&gt;&lt;br&gt;

The PHACS Cardiac Toxicity Substudy was supported by the National Heart, Lung, and Blood Institute through grant R01HL137558 and by the Eunice Kennedy Shriver National Institute of Child Health & Human Development and other NIH institutes by grant P01HD103133 for the Pediatric HIV/AIDS Cohort Study (PHACS) network.&lt;br&gt;&lt;br&gt;

More information about the Pediatric HIV/AIDS Cohort Study (PHACS) network can be found at https://phacsstudy.org. Datasets are publicly available for the PHACS AMP study and AMP Up Study on the NICHD Data and Specimen Hub (DASH), at the following:&lt;br&gt;
AMP: https://dash.nichd.nih.gov/study/17510 &lt;br&gt;
AMP Up: https://dash.nichd.nih.gov/study/428666
description: See the following references for additional details:

Urbina EM, Yu W, Williams PL, Sawyer G, Van Dyke R, Colan S, Lipshultz SE. Central arterial stiffness in 
young adults with perinatal HIV exposure & infection. AIDS. 2025 May 1: 39(6):701-707. 
https://pubmed.ncbi.nlm.nih.gov/39874123/

Wilkinson JD, Williams PL, Yu Wendy, Colan SD, Mendez A, Zachariah JPV, VanDyke RB, Shearer WT, Margossian RE and Lipshultz SE for the Pediatric HIV/AIDS Cohort Study. Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children. AIDS 2018; 132(10):1267-1277. http://www.ncbi.nlm.nih.gov/pubmed/29596110

Lipshultz SE, Williams PL, Wilkinson JD, Leister E, Van Dyke R, Shearer WT, Rich KC, Hazra R, Kaltman J, Jacobson D, Dooley LB, Scott GW, Rabideau N, and Colan SD for the Pediatric HIV/AIDS Cohort Study. Cardiac status of HIV-infected children treated with long-term combination antiretroviral therapy: results from the Adolescent Master Protocol of the NIH multicentre Pediatric HIV/AIDS Cohort Study. JAMA Pediatrics 2013; 167(6):520-7; http://www.ncbi.nlm.nih.gov/pubmed/23608879

Van Dyke RB, Sawyer GS, Williams PL, Yu W, Mendez AJ, Gerschenson M, Attia E, Lipshultz SE. Changes in Inflammatory Biomarkers Among Young Adults with Perinatal HIV Infection and Exposure. Conference on Retroviruses and Opportunistic Infections 2025, San Francisco CA , Poster #1073, March 12, 2025.