cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/124505
title: Transmissometer data collected during research cruise PE16-18 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352369
title: Candidature au prix de thèse en radiosciences

description: Ce dossier zip contient le dossier de candidature au prix de thèse en radiosciences de Quentin Nénon.<br>
DOI: 10.6084/m9.figshare.7352369.v1
title: Candidature au prix de thèse en radiosciences

description: Ce dossier zip contient le dossier de candidature au prix de thèse en radiosciences de Quentin Nénon.<br>
DOI: 10.7284/124506
title: TSG (Thermosalinograph) data collected during research cruise PE16-18 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124512
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-19A using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124513
title: Barometer data collected during research cruise PE16-19B using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124597
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-19B using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124517
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-19B using a Trimble DSM232 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124514
title: Hygrometer data collected during research cruise PE16-19B using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124515
title: Transmissometer data collected during research cruise PE16-19B using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124516
title: TSG (Thermosalinograph) data collected during research cruise PE16-19B using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126345
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE16-20 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124518
title: Barometer data collected during research cruise PE16-20 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124598
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-20 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124574
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-20 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124519
title: Hygrometer data collected during research cruise PE16-20 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.21954/ou.rd.7352270
title: OpenMARS MY24-27 standard database

description: The Open access to Mars Assimilated Remote Soundings (OpenMARS) database is a reanalysis product combining past spacecraft observations with a state-of-the-art Mars Global Circulation Model (GCM). The OpenMARS product is a global surface/atmosphere reference database of key variables for multiple Mars years.<br><br>Spacecraft observations of column dust optical depth and temperature profiles from the Thermal Emission Spectrometer (TES) instrument on the Mars Global Surveyor spacecraft are combined with a Mars GCM used at the Open University. The standard database includes 2-hourly output of key dynamic and surface variables such as zonal/meridional wind, temperature as a function of altitude and column dust optical depth.<br>Extended details on this dataset can be found in the OpenMARS-MY24-27-reference-manual.pdf document included in this repository.<br>This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633127.<br>
DOI: 10.21954/ou.rd.7352270.v1
title: OpenMARS MY24-27 standard database

description: The Open access to Mars Assimilated Remote Soundings (OpenMARS) database is a reanalysis product combining past spacecraft observations with a state-of-the-art Mars Global Circulation Model (GCM). The OpenMARS product is a global surface/atmosphere reference database of key variables for multiple Mars years.<br><br>Spacecraft observations of column dust optical depth and temperature profiles from the Thermal Emission Spectrometer (TES) instrument on the Mars Global Surveyor spacecraft are combined with a Mars GCM used at the Open University. The standard database includes 2-hourly output of key dynamic and surface variables such as zonal/meridional wind, temperature as a function of altitude and column dust optical depth.<br>Extended details on this dataset can be found in the OpenMARS-MY24-27-reference-manual.pdf document included in this repository.<br>This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633127.<br>
DOI: 10.6084/m9.figshare.7352264
title: The leaky lung test: a pilot study using inhaled mannitol to measure airway barrier function in asthma

description: <i>Objective</i>: Airway epithelial barrier dysfunction is emerging as an important feature of asthma pathogenesis, but this is difficult to measure in individual subjects. We aimed to develop a noninvasive way to measure airway permeability in asthma. <i>Methods</i>: Healthy controls and subjects with mild asthma inhaled dry powder mannitol in a dose-escalating manner on two separate occasions, stopping at 155 mg or 315 mg. Serum mannitol levels were measured at baseline and then 30, 90, and 150 min after mannitol inhalation. Mannitol absorption was compared with measurements of airflow obstruction (FEV1) and airway inflammation (FeNO). <i>Results</i>: Serum mannitol levels increased in a time- and dose-dependent manner in both healthy control and subjects with asthma. There were no significant differences in mannitol absorption when comparing healthy controls and subjects with asthma. Mannitol absorption did not correlate with markers of airway obstruction or inflammation. <i>Conclusions</i>: Measuring serum concentrations of mannitol after inhalation challenge can potentially provide insights into airway barrier function in asthma.
DOI: 10.7284/124520
title: Transmissometer data collected during research cruise PE16-20 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352264.v2
title: The leaky lung test: a pilot study using inhaled mannitol to measure airway barrier function in asthma

description: <i>Objective</i>: Airway epithelial barrier dysfunction is emerging as an important feature of asthma pathogenesis, but this is difficult to measure in individual subjects. We aimed to develop a noninvasive way to measure airway permeability in asthma. <i>Methods</i>: Healthy controls and subjects with mild asthma inhaled dry powder mannitol in a dose-escalating manner on two separate occasions, stopping at 155 mg or 315 mg. Serum mannitol levels were measured at baseline and then 30, 90, and 150 min after mannitol inhalation. Mannitol absorption was compared with measurements of airflow obstruction (FEV1) and airway inflammation (FeNO). <i>Results</i>: Serum mannitol levels increased in a time- and dose-dependent manner in both healthy control and subjects with asthma. There were no significant differences in mannitol absorption when comparing healthy controls and subjects with asthma. Mannitol absorption did not correlate with markers of airway obstruction or inflammation. <i>Conclusions</i>: Measuring serum concentrations of mannitol after inhalation challenge can potentially provide insights into airway barrier function in asthma.
DOI: 10.6084/m9.figshare.7352264.v1
title: The leaky lung test: A pilot study using inhaled mannitol to measure airway barrier function in asthma

description: <i>Objective</i>: Airway epithelial barrier dysfunction is emerging as an important feature of asthma pathogenesis, but this is difficult to measure in individual subjects. We aimed to develop a noninvasive way to measure airway permeability in asthma. <i>Methods</i>: Healthy controls and subjects with mild asthma inhaled dry powder mannitol in a dose-escalating manner on two separate occasions, stopping at 155 mg or 315 mg. Serum mannitol levels were measured at baseline and then 30, 90, and 150 min after mannitol inhalation. Mannitol absorption was compared with measurements of airflow obstruction (FEV1) and airway inflammation (FeNO). <i>Results</i>: Serum mannitol levels increased in a time- and dose-dependent manner in both healthy control and subjects with asthma. There were no significant differences in mannitol absorption when comparing healthy controls and subjects with asthma. Mannitol absorption did not correlate with markers of airway obstruction or inflammation. <i>Conclusions</i>: Measuring serum concentrations of mannitol after inhalation challenge can potentially provide insights into airway barrier function in asthma.
DOI: 10.7284/124521
title: TSG (Thermosalinograph) data collected during research cruise PE16-20 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352246
title: HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells

description: Cancer stem-like cells (CSCs), a small population of pluripotent cells residing within heterogeneous tumor mass, remain highly resistant to various chemotherapies as compared to the differentiated cancer cells. It is being postulated that CSCs possess unique molecular mechanisms, such as autophagic homeostasis, that allow CSCs to withstand the therapeutic assaults. Here we demonstrate that HDAC6 inhibition differentially modulates macroautophagy/autophagy in CSCs as compared to that of differentiated cancer cells. Using human and murine CSC models and differentiated cells, we show that the inhibition or knockdown (KD) of HDAC6 decreases CSC pluripotency by downregulating major pluripotency factors POU5F1, NANOG and SOX2. This decreased HDAC6 expression increases ACTB, TUBB3 and CSN2 expression and promotes differentiation in CSCs in an apoptosis-independent manner. Mechanistically, HDAC6 KD in CSCs decreases pluripotency by promoting autophagy, whereas the inhibition of pluripotency via retinoic acid treatment, POU5F1 or autophagy-related gene (<i>ATG7</i> and <i>ATG12</i>) KD in CSCs decreases HDAC6 expression and promotes differentiation. Interestingly, HDAC6 KD-mediated CSC growth inhibition is further enhanced in the presence of autophagy inducers Tat-Beclin 1 peptide and rapamycin. In contrast to the results observed in CSCs, HDAC6 KD in differentiated breast cancer cells downregulates autophagy and increases apoptosis. Furthermore, the autophagy regulator p-MTOR, upstream negative regulators of p-MTOR (TSC1 and TSC2) and downstream effectors of p-MTOR (p-RPS6KB and p-EIF4EBP1) are differentially regulated in CSCs versus differentiated cancer cells following HDAC6 KD. Overall these data identify the differential regulation of autophagy as a molecular link behind the differing chemo-susceptibility of CSCs and differentiated cancer cells.
DOI: 10.7284/126346
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE16-21 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352240
title: Comparison of fibrosis depth in a scar after partial nephrectomy using sutures and a hemostatic sponge. Complementary database.

description: This is the dataset containing outcome measurements to the publication: Comparison of fibrosis depth in a scar after partial nephrectomy using sutures and a hemostatic sponge.
DOI: 10.6084/m9.figshare.7352246.v1
title: HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells

description: Cancer stem-like cells (CSCs), a small population of pluripotent cells residing within heterogeneous tumor mass, remain highly resistant to various chemotherapies as compared to the differentiated cancer cells. It is being postulated that CSCs possess unique molecular mechanisms, such as autophagic homeostasis, that allow CSCs to withstand the therapeutic assaults. Here we demonstrate that HDAC6 inhibition differentially modulates macroautophagy/autophagy in CSCs as compared to that of differentiated cancer cells. Using human and murine CSC models and differentiated cells, we show that the inhibition or knockdown (KD) of HDAC6 decreases CSC pluripotency by downregulating major pluripotency factors POU5F1, NANOG and SOX2. This decreased HDAC6 expression increases ACTB, TUBB3 and CSN2 expression and promotes differentiation in CSCs in an apoptosis-independent manner. Mechanistically, HDAC6 KD in CSCs decreases pluripotency by promoting autophagy, whereas the inhibition of pluripotency via retinoic acid treatment, POU5F1 or autophagy-related gene (<i>ATG7</i> and <i>ATG12</i>) KD in CSCs decreases HDAC6 expression and promotes differentiation. Interestingly, HDAC6 KD-mediated CSC growth inhibition is further enhanced in the presence of autophagy inducers Tat-Beclin 1 peptide and rapamycin. In contrast to the results observed in CSCs, HDAC6 KD in differentiated breast cancer cells downregulates autophagy and increases apoptosis. Furthermore, the autophagy regulator p-MTOR, upstream negative regulators of p-MTOR (TSC1 and TSC2) and downstream effectors of p-MTOR (p-RPS6KB and p-EIF4EBP1) are differentially regulated in CSCs versus differentiated cancer cells following HDAC6 KD. Overall these data identify the differential regulation of autophagy as a molecular link behind the differing chemo-susceptibility of CSCs and differentiated cancer cells.
DOI: 10.11583/dtu.7352237
title: EEG spectrogram data for "Speech-specific audiovisual integration modulates induced theta-band oscillations"

description: The data provided here are power spectrograms of electroencephalograms (EEG) from the two datasets referenced in the article "Speech-specific audiovisual integration modulates induced theta-band oscillations" by Lindborg, Baart, Stekelenburg, Vroomen, Andersen (submitted for publication in 2018).<br>The folder contains two data files and a README.txt file describing how to open the data files and access the data.<br>The EEG used to produce the spectrograms in the current study was originally recorded for two previously published studies: Baart, Stekelenburg & Vroomen, Neuropsychologia (2014), and Stekelenburg & Vroomen (2012). See 'References' for links.<br>
DOI: 10.7284/124522
title: Barometer data collected during research cruise PE16-21 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.11583/dtu.7352237.v1
title: EEG spectrogram data for "Speech-specific audiovisual integration modulates induced theta-band oscillations"

description: The data provided here are power spectrograms of electroencephalograms (EEG) from the two datasets referenced in the article "Speech-specific audiovisual integration modulates induced theta-band oscillations" by Lindborg, Baart, Stekelenburg, Vroomen, Andersen (submitted for publication in 2018).<br>The folder contains two data files and a README.txt file describing how to open the data files and access the data.<br>The EEG used to produce the spectrograms in the current study was originally recorded for two previously published studies: Baart, Stekelenburg & Vroomen, Neuropsychologia (2014), and Stekelenburg & Vroomen (2012). See 'References' for links.<br>
DOI: 10.6084/m9.figshare.7352219
title: InSAR Meteorology Dataset

description: Dataset of precipitable water vapor and rain from the WRF model, before and after assimilating PWV maps, estimated from interferograms generated from SAR images acquired by Sentinel-1, on the southern part of the Appalachian Mountains. A complete description of this dataset can be seen in the article "<i>InSAR Meteorology: </i>High-resolution Geodetic Data Can Increase Atmospheric Predictability", submitted to <i>Geophysical Research Letters</i> (GRL).
DOI: 10.7284/124599
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise PE16-21 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352216
title: Supplementary Material for: An Objective, Comprehensive and Flexible Statistical Framework for Detecting Early Warning Signs of Mental Health Problems

description: Medicine
DOI: 10.6084/m9.figshare.7352219.v1
title: InSAR Meteorology Dataset

description: Dataset of precipitable water vapor and rain from the WRF model, before and after assimilating PWV maps, estimated from interferograms generated from SAR images acquired by Sentinel-1, on the southern part of the Appalachian Mountains. A complete description of this dataset can be seen in the article "<i>InSAR Meteorology: </i>High-resolution Geodetic Data Can Increase Atmospheric Predictability", submitted to <i>Geophysical Research Letters</i> (GRL).
DOI: 10.7284/124575
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-21 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352216.v1
title: Supplementary Material for: An Objective, Comprehensive and Flexible Statistical Framework for Detecting Early Warning Signs of Mental Health Problems

description: Medicine
DOI: 10.7284/124523
title: Hygrometer data collected during research cruise PE16-21 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124524
title: Transmissometer data collected during research cruise PE16-21 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124576
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-22 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124534
title: Barometer data collected during research cruise PE16-25 using a Vaisala PTB101B instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124578
title: GNSS (Global Navigation Satellite System) data collected during research cruise PE16-25 using a Ashtech ADU800 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124535
title: Hygrometer data collected during research cruise PE16-25 using a Vaisala HMP45 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124536
title: Transmissometer data collected during research cruise PE16-25 using a WET Labs C-Star instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124537
title: TSG (Thermosalinograph) data collected during research cruise PE16-25 using a Sea-Bird SBE-21 instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7352105
title: Supplementary Material for: Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage

description: <b><i>Background/Aims:</i></b> Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation network analysis (WGCNA), and explore related functions. <b><i>Methods:</i></b> GSE66107, GSE93798, GSE30528, GSE32591 gene expression data including podocyte injury models or glomeruli in CKD patients were downloaded from the GEO database. R was used for data analysis. Differentially expressed genes (DEGs) (FDR&lt; 0.05 or |Fold Change|≥1.5) in GSE993395 were assessed by WGCNA. According to Gene Ontology (GO) and known podocyte standard genes (PSGs), podocyte injury-associated modules were defined, with hub genes selected based on average intramodular connectivity. The Cytoscape software was used for network visualization. Nephroseq was used to assess the clinical significance of hub genes. Small interfering RNA (siRNA) was used to evaluate the roles of hub genes in podocyte injury <b><i>Results:</i></b> Totally 7957 DEGs were screened, with 15 (co.DEGs) altered in all 4 datasets; 4031 DEGs were used for WGCNA, encompassing 12 modules. Green modules (most PSGs and co.DEGs) were significantly enriched in glomerular development, and considered podocyte injury-associated modules. Furthermore, MAGI2 (a hub gene) was also a co.DEG and PSG. Glomerular MAGI2 levels were reduced in various kidney diseases, and positively and negatively associated with glomerular filtration rate and urinary protein levels in CKD patients. Moreover, MAIG2 knockdown reduced NPHS2, CD2AP and SYNPO levels, and induced podocyte rearrangement and apoptosis. <b><i>Conclusion:</i></b> MAGI2 identified by WGCNA regulates cytoskeletal rearrangement in podocytes, with its loss predisposing to proteinuria and CKD.
DOI: 10.7284/126351
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise PE16-26 using a Hawaii UHDAS instrument system onboard the platform RV Pelican

description: Original (unprocessed) data collected during a Field_expedition