cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30210024.v1
title: Inhibition of lipolysis in visceral adipose tissue from obese mice and humans prevents impairment of endothelial Kir2.1 channels

description: Accumulation of abdominal visceral adipose tissue (VAT) is a major risk factor for cardiovascular disease. Obesity-induced endothelial dysfunction is a precursor to severe disease, and we and others have shown that arteries embedded in VAT, but not subcutaneous adipose tissue, exhibit robust endothelial dysfunction. Using a mouse model of diet-induced obesity, we recently linked VAT from obese mice to the impairment of endothelial Kir2.1, a critical regulator of endothelial function. However, the mechanism by which VAT impairs Kir2.1 is unclear. As Kir2.1 impairment is dependent on endothelial CD36, we hypothesized that lipolytic VAT induces Kir2.1 impairment through fatty acids (FA). To test this, we first treated endothelial cells with palmitic acid (PA) to determine whether the addition of exogenous FAs recapitulated our original finding of Kir2.1 dysfunction when challenged with VAT. PA inhibited Kir2.1 assessed via whole-cell patch-clamp electrophysiology, an effect that was dependent on endothelial CD36. To determine whether inhibiting VAT lipolysis prevents Kir2.1 dysfunction in the presence of VAT in obese mice and humans, VAT was pretreated with small molecule inhibitors of adipose triglyceride lipase prior to incubating endothelial cells with adipose tissue. This approach also prevented VAT-induced impairment of endothelial Kir2.1 suggesting that VAT-derived FAs may play a role. Furthermore, inhibition of lipolysis in the VAT of obese mice and humans significantly reduced endothelial FA uptake, similar to that observed when CD36 was downregulated. These findings advance our understanding of the relationship between VAT and endothelial Kir2.1 impairment and place VAT-derived FAs as potential paracrine mediators. These findings advance our understanding of the role of VAT in mediating endothelial cell dysfunction by highlighting the impact of adipose lipolysis and FAs on Kir2.1 channels in obesity. The present findings, generated from a mouse model of diet-induced obesity and adipose tissue from humans with obesity, suggest that VAT-derived FA may promote endothelial Kir2.1 dysfunction, perhaps following elevated FA uptake, as an underlying mechanism governing obesity-induced endothelial dysfunction.
DOI: 10.5281/zenodo.17865661
title: Developmental Speed and Chronological Time Exert Distinct Effects on the Spontaneous Mutation Rate in Chironomus riparius
DOI: 10.5281/zenodo.17865662
title: Developmental Speed and Chronological Time Exert Distinct Effects on the Spontaneous Mutation Rate in Chironomus riparius
DOI: 10.6084/m9.figshare.29816926
title: Genetic silencing of K<sub>Ca</sub>3.1 inhibits atherosclerosis in ApoE null mice

description: Increased expression of K<sub>Ca</sub>3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of K<sub>Ca</sub>3.1 in limiting atherosclerosis has been demonstrated in mice and pigs, however direct, loss-of-function, i.e. gene silencing, studies are absent. Therefore, we generated K<sub>Ca</sub>3.1<sup>−/−</sup>Apoe<sup>−/−</sup> (DKO) mice and assessed lesion development in the brachiocephalic artery (BCA) of DKO versus Apoe<sup>−/−</sup> mice on a Western diet for 3 months. In BCAs of DKO mice, lesion size and relative stenosis were reduced by ~70% compared to Apoe<sup>−/−</sup> mice, with no effect on medial or lumen area. Additionally, DKO mice exhibited a significant reduction in macrophage content within plaques compared to Apoe<sup>−/−</sup> mice, independent of sex. <i>In vitro</i> migration assays showed a significant reduction in migration of bone marrow-derived macrophages (BMDMs) from DKO mice compared to those from Apoe<sup>−/−</sup> mice. <i>In vitro</i> experiments using rat aortic smooth muscle cells revealed inhibition of PDGF-BB-induced MCP1/Ccl2 expression upon K<sub>Ca</sub>3.1 inhibition, while activation of K<sub>Ca</sub>3.1 further enhanced MCP1/Ccl2 expression. Both <i>in vivo</i> and <i>in vitro</i> analyses showed that silencing K<sub>Ca</sub>3.1 had no significant effect on the collagen content of plaque. RNAseq analysis of BCA samples from DKO and Apoe<sup>−/−</sup> mice revealed PPAR-dependent signaling as a potential key mediator of the reduction in atherosclerosis due to K<sub>Ca</sub>3.1 silencing. Overall, this study provides the first genetic evidence that K<sub>Ca</sub>3.1 is a critical regulator of atherosclerotic lesion development and composition and provides novel mechanistic insight into the link between K<sub>Ca</sub>3.1 and atherosclerosis.
DOI: 10.6084/m9.figshare.29816926.v1
title: Genetic silencing of K<sub>Ca</sub>3.1 inhibits atherosclerosis in ApoE null mice

description: Increased expression of K<sub>Ca</sub>3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of K<sub>Ca</sub>3.1 in limiting atherosclerosis has been demonstrated in mice and pigs, however direct, loss-of-function, i.e. gene silencing, studies are absent. Therefore, we generated K<sub>Ca</sub>3.1<sup>−/−</sup>Apoe<sup>−/−</sup> (DKO) mice and assessed lesion development in the brachiocephalic artery (BCA) of DKO versus Apoe<sup>−/−</sup> mice on a Western diet for 3 months. In BCAs of DKO mice, lesion size and relative stenosis were reduced by ~70% compared to Apoe<sup>−/−</sup> mice, with no effect on medial or lumen area. Additionally, DKO mice exhibited a significant reduction in macrophage content within plaques compared to Apoe<sup>−/−</sup> mice, independent of sex. <i>In vitro</i> migration assays showed a significant reduction in migration of bone marrow-derived macrophages (BMDMs) from DKO mice compared to those from Apoe<sup>−/−</sup> mice. <i>In vitro</i> experiments using rat aortic smooth muscle cells revealed inhibition of PDGF-BB-induced MCP1/Ccl2 expression upon K<sub>Ca</sub>3.1 inhibition, while activation of K<sub>Ca</sub>3.1 further enhanced MCP1/Ccl2 expression. Both <i>in vivo</i> and <i>in vitro</i> analyses showed that silencing K<sub>Ca</sub>3.1 had no significant effect on the collagen content of plaque. RNAseq analysis of BCA samples from DKO and Apoe<sup>−/−</sup> mice revealed PPAR-dependent signaling as a potential key mediator of the reduction in atherosclerosis due to K<sub>Ca</sub>3.1 silencing. Overall, this study provides the first genetic evidence that K<sub>Ca</sub>3.1 is a critical regulator of atherosclerotic lesion development and composition and provides novel mechanistic insight into the link between K<sub>Ca</sub>3.1 and atherosclerosis.
DOI: 10.15468/dl.zkg7h8
title: Occurrence Download

description: A dataset containing 156 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Grania atlantica",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 156 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040313-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17026/ar/z6gmxb
title: PAN-00161196 - terra sigillata kom type Drag. 37 (EG)

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00161196&lt;/p&gt;
description: Modified: 2025-11-03T11:37:08+01:00
DOI: 10.15468/dl.keu6sh
title: Occurrence Download

description: A dataset containing 30538 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cannabis"
 ]
}

 The dataset includes 30538 records from 834 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0040314-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.knpxyv
title: Occurrence Download

description: A dataset containing 19 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Bulbophyllum muricatum J.J.Sm."
 ]
}

 The dataset includes 19 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065326-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wxh7sg
title: Occurrence Download

description: A dataset containing 263 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Argemone gracilenta Greene"
 ]
}

 The dataset includes 263 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0189338-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kv6ypo
title: Occurrence Download

description: A dataset containing 1011 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Cuba",
 "TaxonKey is Ipomoea L."
 ]
}

 The dataset includes 1011 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029830-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8dg8zr
title: Occurrence Download

description: A dataset containing 303 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Periploca sepium Bunge"
 ]
}

 The dataset includes 303 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005503-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.npc7ab
title: Occurrence Download

description: A dataset containing 13136 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ilex verticillata (L.) A.Gray",
 "Year is greater than or equal to 1900",
 "HasCoordinate is true"
 ]
}

 The dataset includes 13136 records from 125 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013442-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eprqs9
title: Occurrence Download

description: A dataset containing 9494 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Agaricus arvensis Schaeff."
 ]
}

 The dataset includes 9494 records from 293 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028862-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uko43m
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Peperomia muelleri C.DC."
 ]
}

 The dataset includes 5 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029830-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nygnqj
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllanthus korthalsii Müll.Arg."
 ]
}

 The dataset includes 9 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003112-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.geqmon
title: Occurrence Download

description: A dataset containing 1805 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Panthera tigris (Linnaeus, 1758)"
 ]
}

 The dataset includes 1805 records from 85 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029830-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zjh5t9
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chionanthus littoreus Miq."
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0089786-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rhayp5
title: Occurrence Download

description: A dataset containing 7720 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dichrostachys cinerea (L.) Wight & Arn."
 ]
}

 The dataset includes 7720 records from 203 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0178652-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kjr3do
title: Occurrence Download

description: A dataset containing 10948 species occurrences available in GBIF matching the query:
{
 "or" : [
 "TaxonKey is Clidemia hirta (L.) D.Don",
 "TaxonKey is Cinchona pubescens Vahl"
 ]
}

 The dataset includes 10948 records from 252 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029830-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t8agmy
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Asclepias monticola N.E.Br."
 ]
}

 The dataset includes 5 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028839-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xzzzf2
title: Occurrence Download

description: A dataset containing 3241555 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-76 0,-66 7,-103 28,-123 57,-180 67,-180 0,-76 0))",
 "Depth is greater than or equal to 0m",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil)"
 ]
 }
 },
 "TaxonKey is Animalia",
 "CoordinateUncertaintyInMeters is less than 1e+05"
 ]
}

 The dataset includes 3241555 records from 546 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0145285-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bqf7rd
title: Occurrence Download

description: A dataset containing 152331 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "or" : [
 "InstitutionCode is 7006",
 "InstitutionCode is clo",
 "InstitutionCode is uct-adu",
 "InstitutionCode is uac",
 "InstitutionCode is esa",
 "InstitutionCode is seor",
 "InstitutionCode is inaturalist",
 "InstitutionCode is edp",
 "InstitutionCode is seo-birdlife"
 ]
 },
 "TaxonKey is Estrilda astrild (Linnaeus, 1758)"
 ]
}

 The dataset includes 152331 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0191714-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cj4yjj
title: Occurrence Download

description: A dataset containing 1011 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Cuba",
 "TaxonKey is Ipomoea L."
 ]
}

 The dataset includes 1011 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029831-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3908fv
title: Occurrence Download

description: A dataset containing 369 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Amphiroa misakiensis",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 369 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005072-180824113759888/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.43vufz
title: Occurrence Download

description: A dataset containing 49 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hiplyra variegata (Rüppell, 1830)"
 ]
}

 The dataset includes 49 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0121340-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-23883
title: Letters of Mundell, Thomas, Secretary of Home Reference Missionary Council, PMU, June 1925-July 1927

description: [description english/roman)] Pentecostal Missionary Union [PMU]/Assemblies of God [AoG] Home Reference Missionary Council outgoing correspondence from Home Reference Missionary Council secretary Thomas Mundell, including index for correspondence 109 pages and correspondence 2026 pages. Outgoing letters sent by Mundell on behalf of Assemblies of God [AoG] Home Reference Missionary Council
DOI: 10.15468/dl.2d6q3r
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is incertae sedis",
 "Year is greater than 2013",
 "Geometry MULTIPOLYGON (((12.947524 41.363681,12.947341 41.363802,12.946924 41.364132,12.946618 41.364363,12.946231 41.364669,12.945003 41.365589,12.944474 41.365985,12.943767 41.366469,12.942635 41.367201,12.941341 41.368137,12.939809 41.369121,12.939479 41.36934,12.938189 41.370199,12.937034 41.370959,12.936151 41.371561,12.935578 41.371914,12.935113 41.372231,12.934555 41.372656,12.933388 41.373439,12.932941 41.373724,12.932468 41.374006,12.932191 41.374169,12.931524 41.374561,12.931211 41.374742,12.930172 41.375372,12.92911 41.376007,12.928633 41.376334,12.928049 41.376715,12.927743 41.376896,12.927287 41.377137,12.926443 41.377625,12.924944 41.378554,12.924449 41.3789,12.92406 41.379111,12.923723 41.379285,12.923391 41.379449,12.923084 41.379622,12.922718 41.379855,12.921953 41.380363,12.921422 41.380705,12.921139 41.380877,12.920304 41.381301,12.919944 41.381485,12.918959 41.382108,12.917656 41.38295,12.917149 41.383282,12.916723 41.383495,12.916432 41.383638,12.916353 41.383701,12.91779 41.385081,12.918719 41.385833,12.919685 41.386329,12.921106 41.386594,12.930786 41.386694,12.933518 41.386815,12.933534 41.386797,12.936313 41.387153,12.936314 41.387148,12.93644 41.387161,12.93646 41.387142,12.936524 41.387145,12.940219 41.38446,12.942677 41.382758,12.951876 41.378298,12.952051 41.378204,12.954568 41.377312,12.955406 41.376615,12.958689 41.373214,12.959004 41.37286,12.958878 41.372758,12.95869 41.372608,12.956715 41.371019,12.947727 41.363791,12.947578 41.36367,12.947566 41.363661,12.947561 41.363657,12.947524 41.363681)))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033357-230530130749713/datasets/export for details.
DOI: 10.25549/pcra-c14-24020
title: Letters of Mundell, Thomas, Secretary of Home Reference Missionary Council, PMU, June 1925-July 1927

description: [description english/roman)] Pentecostal Missionary Union [PMU]/Assemblies of God [AoG] Home Reference Missionary Council outgoing correspondence from Home Reference Missionary Council secretary Thomas Mundell, including index for correspondence 109 pages and correspondence 2026 pages. Outgoing letters sent by Mundell on behalf of Assemblies of God [AoG] Home Reference Missionary Council
DOI: 10.15468/dl.avuj5b
title: Occurrence Download

description: A dataset containing 101 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-80.6728102999999948 41.0333668999999972, -80.6728102999999948 41.0352656499999995, -80.6728102999999948 41.0368479400000012, -80.6728102999999948 41.0381137800000033, -80.6728102999999948 41.0396960699999980, -80.6728102999999948 41.0419112800000008, -80.6728102999999948 41.0438100300000031, -80.6728102999999948 41.0463416999999993, -80.6695499399999960 41.0463416999999993, -80.6664999200000068 41.0463416999999993, -80.6638705999999956 41.0463416999999993, -80.6622930000000053 41.0463416999999993, -80.6622930000000053 41.0446539200000018, -80.6622930000000053 41.0425442000000018, -80.6622930000000053 41.0411728799999977, -80.6622930000000053 41.0392741300000026, -80.6622930000000053 41.0376918300000000, -80.6622930000000053 41.0355821100000000, -80.6622930000000053 41.0333668999999972, -80.6639757699999933 41.0333668999999972, -80.6658688800000050 41.0333668999999972, -80.6692344199999951 41.0333668999999972, -80.6713378799999958 41.0333668999999972, -80.6728102999999948 41.0333668999999972))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 101 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0094658-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fdwxcn
title: Occurrence Download

description: A dataset containing 592 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Arundo donax L."
 ]
}

 The dataset includes 592 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009658-180730143533302/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hbf6ez
title: Occurrence Download

description: A dataset containing 1354 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "TaxonKey is Sibon nebulatus (Linnaeus, 1758)"
 ]
}

 The dataset includes 1354 records from 99 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033381-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-17507
title: Minute Book no. 6, PMU, AoG GB, HRMC, June 1925 - July 1927

description: [description english/roman)] Pentecostal Missionary Union [PMU]/Assemblies of God [AoG] Home Reference Missionary Council [HRMC] minute Book No.6, including appointments to Home Reference Missionary Council, 24 pages of index followed by 204 pages of minutes relating to missionaries and ends with 2 pages of accounts. All matters relating to Assemblies of God [AoG] Home Reference Missionary Council council member appointments, decisions, policy and missionary personnel issues.