cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12056817.v1
title: Is Surgical Treatment an Option for Locally Advanced Cervical Cancer in the Presence of Central Residual Tumor after Chemoradiotherapy?

description: Abstract Objective To evaluate the outcomes of surgical treatment in patients with chemoradiotherapy (CRT)-resistant and locally advanced cervical cancer (LACC). Methods Patients with LACC who underwent surgery due to resistance to CRT between 2005 and 2015 were reviewed retrospectively. Disease-free survival (DFS) and overall survival (OS) related factors were analyzed. Results A total of 23 patients were included in the study and the median age was 51 years old. A total of 14 patients (60.8%) experienced recurrence; among these recurrences, 8 of them were local, 5 were distant, 1 was both distant and local. A total of 9 patients (39%) died. The Median DFS and OS durations were 15 and 32 months, respectively. A total of 17 patients (74%) had undergone simple hysterectomy, 4 (17%) radical hysterectomy, and 2 (9%) total pelvic exenteration. Postoperative grade 3 and 4 complications were seen in 12 patients (52%). Macroscopic tumor presence in the pathology specimen was associated with distant recurrence and positive surgical margins with local recurrence (Log-Rank test p = 0.029 and p = 0.048, respectively). The only factor associated with OS was surgical margin positivity (Log-Rank test p = 0.008). The type of surgery, grades 3 and 4 postoperative complications, brachytherapy, and tumor histology were not associated with recurrence. Conclusion In patients with LACC, hysterectomy is an option in the presence of a central residual tumor after CRT. However, the risk of grades 3 and 4 complications of performed surgery is high. The presence of macroscopic tumor in the pathology specimen and positive surgical margins are poor prognostic factors. The goal of the surgeon should be to achieve a negative surgical margin. It does not seem important if the surgery is simple or radical.
DOI: 10.6084/m9.figshare.12056802
title: Estudio de los parámetros de freído sobre las propiedades fisicoquímicas de una botana hecha de harinas de maíz, chicharo y salvado de avena

description: Resumen El objetivo de este estudio fue evaluar el efecto de la temperatura y tiempo de freído sobre las propiedades fisicoquímicas: porcentaje de humedad, H; cambio neto de color, ΔE; contenido de grasa, G; índices de absorción, IAA; solubilidad en agua, ISA; densidad aparente, DA; y dureza, D, de un alimento frito tipo botana preparado con una mezcla de harinas de maíz nixtamalizado (HMN), harina de chícharo (HC) y salvado de avena (SA), hidratada al 47%. El estudio mostró que DA y H disminuyeron, mientras que ΔE e IAA se incrementaron con el aumento de la temperatura y el tiempo de freído. Los cambios en ISA y D resultaron estadísticamente no significativos. El análisis de componentes principales, mostró que el 83% de la variabilidad de los datos se puede explicar debido a dos componentes: temperatura (56%) y tiempo (28%). El análisis sensorial mostró que la botana elaborada a 165 °C y 198 s obtuvo mayor aceptación, resultando un alimento con alto contenido de proteína y bajo contenido de grasa.
DOI: 10.6084/m9.figshare.12056814.v1
title: Epistasis of polymorphisms related to the articular cartilage extracellular matrix in knee osteoarthritis: Analysis-based multifactor dimensionality reduction

description: Abstract Osteoarthritis (OA) is a complex disease with a multifactorial etiology. The genetic component is one of the main associated factors, resulting from interactions between genes and environmental factors. The aim of this study was to identify gene-gene interactions (epistasis) of the articular cartilage extracellular matrix (ECM) in knee OA. Ninety-two knee OA patients and 147 healthy individuals were included. Participants were genotyped in order to evaluate nine variants of eight genes associated with ECM metabolism using the OpenArray technology. Epistasis was analyzed using the multifactor dimensionality reduction (MDR) method. The MDR analysis showed significant gene-gene interactions between MMP3 (rs679620) and COL3A1 (rs1800255), and between COL3A1 (rs1800255) and VEGFA (rs699947) polymorphisms, with information gain values of 3.21% and 2.34%, respectively. Furthermore, in our study we found interactions in high-risk genotypes of the HIF1AN, MMP3 and COL3A1 genes; the most representative were [AA+CC+GA], [AA+CT+GA] and [AA+CT+GG], respectively; and low-risk genotypes [AA+CC+GG], [GG+TT+GA] and [AA+TT+GA], respectively. Knowing the interactions of these polymorphisms involved in articular cartilage ECM metabolism could provide a new tool to identify individuals at high risk of developing knee OA.
DOI: 10.6084/m9.figshare.12056796
title: Elastoplastic constitutive modeling for concrete: a theoretical and computational approach

description: Abstract This article presents a study of the plasticity model applicability to concrete in a theoretical framework that generalizes the formulation of constitutive models for physically nonlinear analysis of structures. In this sense, the theoretical framework for the computational implementation of the plasticity mathematical theory is described, detailing the models formulations capable to describe the inelastic behavior of concrete. The loading surfaces associated to Drucker Prager and Ottosen criterion are highlighted. Furthermore, the Cutting Plane return mapping algorithm, necessary to the integration of constitutive relations that govern the behavior of the material in the context of computational plasticity, is described. Finally, numerical simulations are presented, such as the direct tension loading and three-point bending tests. The results of these simulations are compared with those from the literature to verify the model stability and accuracy.
DOI: 10.6084/m9.figshare.12056799
title: Effects of ATRA on diabetic rats with renal ischemia-reperfusion injury

description: Abstract Purpose To explore the role of all-trans retinoic acid (ATRA) in renal ischemia/reperfusion injury of diabetic rats. Methods Sixty adult male rats were randomly divided into 6 groups, including sham group (S group), ischemia-reperfusion group (I/R group), ischemia-reperfusion+ATRA group (A group), diabetic group (D group), diabetic ischemia-reperfusion group (DI/R group), diabetic ischemia-reperfusion +ATRA group (DA group). The levels of creatinine (Cr), cystatin C (Cys-C) and β2-microglobulin (β2-MG) were measured. Morphology of renal tissue was observed under light microscope. Results DJ-1, Nrf2, HO-1 and caspase-3 were detected by western blot. DJ-1, Nrf2, HO-1 and caspase-3 in I/R group, D group and DI/R group was higher than that in S group. Compared with I/R group, Nrf2 and HO-1 in A group was decreased, but caspase-3 was increased. However, Nrf2 in DA group was higher than that in DI/R group, HO-1 and caspase-3 in DA group were lower than that in DI/R group. Compared with group S, Cr, Cys-C and β2-MG in I/R group, A group, D group, and DI/R group were higher. Whereas the levels of Cr, Cys-C, β2-MG and renal injury score in DA group were lower than those in DI/R group. Conclusion ATRA has a protective effect on renal ischemia-reperfusion injury in diabetic rats, maybe relating to DJ/Nrf2 pathway.
DOI: 10.6084/m9.figshare.12056802.v1
title: Estudio de los parámetros de freído sobre las propiedades fisicoquímicas de una botana hecha de harinas de maíz, chicharo y salvado de avena

description: Resumen El objetivo de este estudio fue evaluar el efecto de la temperatura y tiempo de freído sobre las propiedades fisicoquímicas: porcentaje de humedad, H; cambio neto de color, ΔE; contenido de grasa, G; índices de absorción, IAA; solubilidad en agua, ISA; densidad aparente, DA; y dureza, D, de un alimento frito tipo botana preparado con una mezcla de harinas de maíz nixtamalizado (HMN), harina de chícharo (HC) y salvado de avena (SA), hidratada al 47%. El estudio mostró que DA y H disminuyeron, mientras que ΔE e IAA se incrementaron con el aumento de la temperatura y el tiempo de freído. Los cambios en ISA y D resultaron estadísticamente no significativos. El análisis de componentes principales, mostró que el 83% de la variabilidad de los datos se puede explicar debido a dos componentes: temperatura (56%) y tiempo (28%). El análisis sensorial mostró que la botana elaborada a 165 °C y 198 s obtuvo mayor aceptación, resultando un alimento con alto contenido de proteína y bajo contenido de grasa.
DOI: 10.6084/m9.figshare.12056805.v1
title: Postharvest conservation of peaches with the use of edible coatings added with yerba mate extract

description: Abstract The present study had the objective of verifying the potential of the application of cassava starch-based coatings (F), supplemented with yerba mate extract (E) (Ilex paraguariensis St. Hill) in the postharvest conservation of peaches. The fruits used were peaches cv. Della Nona and the applied treatments were: uncoated fruits, fruits with cassava starch-based coatings supplemented with yerba mate extract at concentrations of 0 g L-1 (F + 0% E), 5 g L -1 (F + 5% E), 10 g L-1 (F + 10% E) and 15 g L-1 (F + 15% E). The fruits were stored for 10 days at 1 °C with 95% relative humidity. To evaluate the postharvest quality of fruits, physicochemical analysis was performed, including soluble solids, titratable acidity, weight loss, and firmness. To evaluate the in vitro effect of the coatings on fungus growth Monilinia fructicola, the causal agent of brown rot, conidia germination and the area under the mycelial growth curve were evaluated. In order to evaluate the in vivo brown rot control, the fruits were inoculated with the M. fructicola fungus and evaluated for incidence (%) and infection index (%) and the peroxidase and polyphenol oxidase enzymes. The use of coatings reduced the loss of fruit mass by 50%, an increase of soluble solids content and improved the red color of the fruits, making them more attractive to the consumer. In addition, there was an increase of peroxidase enzyme activity in coated fruits and the coating treatment with 15% of yerba mate inhibited the development of brown rot in peaches.
DOI: 10.6084/m9.figshare.12056793
title: -866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis

description: Abstract Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS). ROS overproduction is a key contributor to the pathogenesis of diabetic kidney disease (DKD). Thus, UCP2 polymorphisms are candidate risk factors for DKD; however, their associations with this complication are still inconclusive. Here, we describe a case-control study and a meta-analysis conducted to investigate the association between UCP2 -866G/A and Ins/Del polymorphisms and DKD. The case-control study comprised 385 patients with type 1 diabetes mellitus (T1DM): 223 patients without DKD and 162 with DKD. UCP2 -866G/A (rs659366) and Ins/Del polymorphisms were genotyped by real-time PCR and conventional PCR, respectively. For the meta-analysis, a literature search was conducted to identify all studies that investigated associations between UCP2 polymorphisms and DKD in patients with T1DM or type 2 diabetes mellitus. Pooled odds ratios were calculated for different inheritance models. Allele and genotype frequencies of -866G/A and Ins/Del polymorphisms did not differ between T1DM case and control groups. Haplotype frequencies were also similar between groups. Four studies plus the present one were eligible for inclusion in the meta-analysis. In agreement with case-control data, the meta-analysis results showed that the -866G/A and Ins/Del polymorphisms were not associated with DKD. In conclusion, our case-control and meta-analysis studies did not indicate an association between the analyzed UCP2 polymorphisms and DKD.
DOI: 10.6084/m9.figshare.12056796.v1
title: Elastoplastic constitutive modeling for concrete: a theoretical and computational approach

description: Abstract This article presents a study of the plasticity model applicability to concrete in a theoretical framework that generalizes the formulation of constitutive models for physically nonlinear analysis of structures. In this sense, the theoretical framework for the computational implementation of the plasticity mathematical theory is described, detailing the models formulations capable to describe the inelastic behavior of concrete. The loading surfaces associated to Drucker Prager and Ottosen criterion are highlighted. Furthermore, the Cutting Plane return mapping algorithm, necessary to the integration of constitutive relations that govern the behavior of the material in the context of computational plasticity, is described. Finally, numerical simulations are presented, such as the direct tension loading and three-point bending tests. The results of these simulations are compared with those from the literature to verify the model stability and accuracy.
DOI: 10.6084/m9.figshare.12056790
title: Modal identification of Bridge 44 of the Carajás Railroad and numerical modeling using the finite element method

description: Abstract Regular use and the effects of time can affect the behavior of a structure. Over time, problems such as the occurrence of small fissures, oxidation of steel elements, and excessive displacements at some points may arise in a structure. In this context, the monitoring of structures through experimental tests has gained more importance, because it allows for the identification of the dynamic characteristics (natural frequencies, mode shapes, and damping rate) of structures. The dynamic characteristics can be obtained through forced vibration tests, which are based on measuring the response of a structure subjected to an excitation of known magnitude, or through tests in which only the structural response is measured, such as free vibration and ambient vibration tests. The present study aims to identify the modal parameters of bridge 44 of the Carajás Railroad, using experimental data obtained on site by monitoring the vibration caused by a group of people jumping, and it compares them with the results obtained through numerical modeling performed using the finite element method, developed in CSiBridge. The modal parameters were obtained using the commercial software ARTeMIS Modal, and stochastic subspace identification was used for modal identification.
DOI: 10.6084/m9.figshare.12056799.v1
title: Effects of ATRA on diabetic rats with renal ischemia-reperfusion injury

description: Abstract Purpose To explore the role of all-trans retinoic acid (ATRA) in renal ischemia/reperfusion injury of diabetic rats. Methods Sixty adult male rats were randomly divided into 6 groups, including sham group (S group), ischemia-reperfusion group (I/R group), ischemia-reperfusion+ATRA group (A group), diabetic group (D group), diabetic ischemia-reperfusion group (DI/R group), diabetic ischemia-reperfusion +ATRA group (DA group). The levels of creatinine (Cr), cystatin C (Cys-C) and β2-microglobulin (β2-MG) were measured. Morphology of renal tissue was observed under light microscope. Results DJ-1, Nrf2, HO-1 and caspase-3 were detected by western blot. DJ-1, Nrf2, HO-1 and caspase-3 in I/R group, D group and DI/R group was higher than that in S group. Compared with I/R group, Nrf2 and HO-1 in A group was decreased, but caspase-3 was increased. However, Nrf2 in DA group was higher than that in DI/R group, HO-1 and caspase-3 in DA group were lower than that in DI/R group. Compared with group S, Cr, Cys-C and β2-MG in I/R group, A group, D group, and DI/R group were higher. Whereas the levels of Cr, Cys-C, β2-MG and renal injury score in DA group were lower than those in DI/R group. Conclusion ATRA has a protective effect on renal ischemia-reperfusion injury in diabetic rats, maybe relating to DJ/Nrf2 pathway.
DOI: 10.6084/m9.figshare.12056784
title: Thermal properties of polypropylene and high modulus polyethylene fibers reinforced concretes

description: Abstract Concrete is one of the materials most used by the construction industry. Reinforcing this material with fibers is a technique used to improve its mechanical properties. Steel and polymer fibers are the main types used in this application and there are few studies about the influence of polymer fibers on the thermal properties of concrete. In order to analyze this influence, the present work carried out thermal conductivity, thermal expansion, and compressive strength after exposure to a temperature of 200 °C on specimens made of concrete with addition of polypropylene (PP) fibers and concrete with addition of high modulus polyethylene (HMPE). It was also conducted thermogravimetric analysis (TGA) on PP and HMPE fibers. The results show that the addition of polymer fibers alters the thermal properties of the concrete, reducing its thermal expansion, for example.
DOI: 10.6084/m9.figshare.12056790.v1
title: Modal identification of Bridge 44 of the Carajás Railroad and numerical modeling using the finite element method

description: Abstract Regular use and the effects of time can affect the behavior of a structure. Over time, problems such as the occurrence of small fissures, oxidation of steel elements, and excessive displacements at some points may arise in a structure. In this context, the monitoring of structures through experimental tests has gained more importance, because it allows for the identification of the dynamic characteristics (natural frequencies, mode shapes, and damping rate) of structures. The dynamic characteristics can be obtained through forced vibration tests, which are based on measuring the response of a structure subjected to an excitation of known magnitude, or through tests in which only the structural response is measured, such as free vibration and ambient vibration tests. The present study aims to identify the modal parameters of bridge 44 of the Carajás Railroad, using experimental data obtained on site by monitoring the vibration caused by a group of people jumping, and it compares them with the results obtained through numerical modeling performed using the finite element method, developed in CSiBridge. The modal parameters were obtained using the commercial software ARTeMIS Modal, and stochastic subspace identification was used for modal identification.
DOI: 10.6084/m9.figshare.12056793.v1
title: -866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis

description: Abstract Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS). ROS overproduction is a key contributor to the pathogenesis of diabetic kidney disease (DKD). Thus, UCP2 polymorphisms are candidate risk factors for DKD; however, their associations with this complication are still inconclusive. Here, we describe a case-control study and a meta-analysis conducted to investigate the association between UCP2 -866G/A and Ins/Del polymorphisms and DKD. The case-control study comprised 385 patients with type 1 diabetes mellitus (T1DM): 223 patients without DKD and 162 with DKD. UCP2 -866G/A (rs659366) and Ins/Del polymorphisms were genotyped by real-time PCR and conventional PCR, respectively. For the meta-analysis, a literature search was conducted to identify all studies that investigated associations between UCP2 polymorphisms and DKD in patients with T1DM or type 2 diabetes mellitus. Pooled odds ratios were calculated for different inheritance models. Allele and genotype frequencies of -866G/A and Ins/Del polymorphisms did not differ between T1DM case and control groups. Haplotype frequencies were also similar between groups. Four studies plus the present one were eligible for inclusion in the meta-analysis. In agreement with case-control data, the meta-analysis results showed that the -866G/A and Ins/Del polymorphisms were not associated with DKD. In conclusion, our case-control and meta-analysis studies did not indicate an association between the analyzed UCP2 polymorphisms and DKD.
DOI: 10.6084/m9.figshare.12056781
title: RATIONAL VOLUMETRIC MODELS: TESTED IN FOREST STANDS OF Acacia mearnsii DE WILD IN SOUTHERN BRAZIL

description: ABSTRACT Tree volumes can alternatively be obtained by ratio estimates, instead of applying linear regression modeling. An interesting question was considered by the authors when comparing the precision of tree volumes obtained by these two statistical approaches, that allowed us to formulate a new hypothesis to conduct this study: “Is it possible to obtain better volume estimates if the form factor is associated only to the exponent of the independent variable that presents higher correlation with the stem volume?”. The research was conducted in commercial stands of black wattle (Acacia mearnsii De Wild) in the municipalities of Cristal, Encruzilhada do Sul and Piratini to answer this question. Forest stands were sampled in a sequence of ages after planting, varying from 1 to 14 years. In each forest stand, trees were felled, and the following characteristics were evaluated: diameter at breast height, total height, and stem scaling. The three age groups were specified according to the behavior of the form factor values. It was proposed three models to be solved by ratio estimates. A comparison of the proposed models with the Schumacher-Hall model, fitted by regression analysis, was done. The model in which the form factor was associated to the exponent of the diameter variable produced the best results, owing to a powerful correlation resulted of this confounding with volume as a dependent variable. Ratio estimates resulted in more accurate tree volumes predominantly, when compared with those obtained by the traditional Schumacher-Hall model fitted through regression analysis. Therefore, we recommend the application of model 2 fitted by ratio estimate.
DOI: 10.6084/m9.figshare.12056778
title: Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors

description: Abstract Introduction Recently it has been reported that a high preoperative neutrophil-lymphocyte ratio and platelet-lymphocyte ratio may be related to increased recurrence risk, tumor aggressiveness, and worsened prognosis in various malignancies. Objective The objective of this research is to explore whether neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in parotid tumors may or may not be used as a cancer marker. Methods This retrospective research has been conducted on a total of 228 patients consisting of 83 healthy persons and 145 patients with a mass in the parotid gland, who applied to a tertiary referral center and underwent surgery. Patients have been divided into two groups by their histopathological findings as malignant or benign parotid tumor. A third group consisting of healthy people has been defined as the control group. Also the malignant parotid tumor group has been divided into two subgroups as early stage and advanced stage. The groups have been compared in terms of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and other laboratory data. Results The average neutrophil-lymphocyte ratio values of malignant parotid tumor, benign parotid tumor, healthy control groups were 2.51, 2.01, 1.79 respectively and the difference was statistically significant (p &lt; 0.001). There was no significant difference between advanced stage and early stage parotid tumor groups in terms of average neutrophil-lymphocyte ratio value (p = 0.782). In dual comparisons, the platelet-lymphocyte ratio value of patients in the malignant group was found out to be statistically significantly higher than that of benign and control groups (p &lt; 0.001 and p = 0.001 respectively). Conclusion To the best of our knowledge our research is the first in the medical literature comparing neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with parotid tumor. neutrophil-lymphocyte ratio and platelet-lymphocyte ratio can serve as cost-effective, repeatable, easily accessible, and helpful inflammatory markers in order to distinguish patients with malignant parotid tumor from healthy people.