cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11678532
title: Mapping of the scientific production of industry 4.0 in the BRICS: reflections and interfaces

description: Abstract This article aims to analyze the recent scientific production about 4.0 Industry from BRICS countries (Brazil, Russia, India, China, and South Africa), published in leading academics journals. The 4.0 Industry incorporates nine technological innovations, which are related, directly and indirectly, to the evolution of Science and Technology (S&T) in BRICS, diagnosed by the evolution of the financial support, the participation in S&T in the Gross Domestic Product (GDP), and the number of researchers and publications, in each member country. The descriptive and exploratory research was built using bibliometrics. The population was made up of texts of the databases Scopus and Web of Science, and the final sample was composed of 51 interdisciplinary articles. The analysis considered indicators of characterization of scientific production, to a certain degree co-occurrence of scientific productivity and scientific collaboration of methodological features of the study. It is concluded that Chinese articles are predominant, and the research indicated the increase of studies about Industry 4.0 in S&T in BRICS. There is still a need to effectively strengthen the cooperation of these countries in the aspects related to the subject, according to agreements already established in recent years. In addition, the academic production shows a vast field to be explored, with the need for cooperation and effective development of common S&T objectives in BRICS.
DOI: 10.6084/m9.figshare.11678535.v1
title: Structural Study of Phenolic Acids by Triple Quadrupole Mass Spectrometry with Electrospray Ionization in Negative Mode and H/D Isotopic Exchange

description: This work reports the theoretical and experimental study of fragmentation reactions in the gas phase of five phenolic acids using triple quadrupole mass spectrometry by electrospray ionization in negative ionic mode, as well as the isotope exchange experiments. MS/MS spectra were analyzed to suggest the fragmentation mechanisms, while theoretical calculations at the theory level B3LYP/6-311+G** were performed to expose the proposed mechanisms viability for this class of compounds. As expected, compounds with aromatic methoxy substitution presented •CH3 radical elimination as the principal fragmentation pathway, forming dystonic ions. Compounds without methoxy substituents dissociate with higher energies losing the CO2, CO and H2O. The isotopic marking experiments indicated the exchange of hydrogens by deuterases in the hydroxyl protons, which corroborates with the proposed mechanisms.
DOI: 10.6084/m9.figshare.11678532.v1
title: Mapping of the scientific production of industry 4.0 in the BRICS: reflections and interfaces

description: Abstract This article aims to analyze the recent scientific production about 4.0 Industry from BRICS countries (Brazil, Russia, India, China, and South Africa), published in leading academics journals. The 4.0 Industry incorporates nine technological innovations, which are related, directly and indirectly, to the evolution of Science and Technology (S&T) in BRICS, diagnosed by the evolution of the financial support, the participation in S&T in the Gross Domestic Product (GDP), and the number of researchers and publications, in each member country. The descriptive and exploratory research was built using bibliometrics. The population was made up of texts of the databases Scopus and Web of Science, and the final sample was composed of 51 interdisciplinary articles. The analysis considered indicators of characterization of scientific production, to a certain degree co-occurrence of scientific productivity and scientific collaboration of methodological features of the study. It is concluded that Chinese articles are predominant, and the research indicated the increase of studies about Industry 4.0 in S&T in BRICS. There is still a need to effectively strengthen the cooperation of these countries in the aspects related to the subject, according to agreements already established in recent years. In addition, the academic production shows a vast field to be explored, with the need for cooperation and effective development of common S&T objectives in BRICS.
DOI: 10.6084/m9.figshare.11678526
title: Organic acids and hydrogen peroxide can replace chlorinated compounds as sanitizers on strawberries, cucumbers and rocket leaves

description: Abstract This work evaluated the effectiveness of 1 and 2% acetic and lactic acid, 3% hydrogen peroxide, 200 mg/L sodium hypochlorite and 200 mg/L sodium dichloroisocyanurate to reducing natural contaminants as well as Salmonella enterica Enteritidis inoculated on the surface of strawberries, cucumbers, and rocket leaves. The reduction of aerobic mesophilic and molds and yeasts was between 1.67 – 2.73 and 0.61 – 1.46 log CFU/g in strawberries, 1.48 – 2.19 and 1.02 – 2.01 log CFU/g on rocket leaves, and 1.10 – 2.08 and 0.88 – 1.58 log CFU/g in cucumbers, respectively. The most effective sanitizers for reducing Salmonella enterica Enteritidis in strawberries were 1% and 2% lactic acid, while in cucumbers and rocket leaves was the 2% lactic acid as well as the 3% hydrogen peroxide, for both samples. The results of this study clearly show the potential of the proposed strategies to replace chlorinated compounds in the sanitization step of fresh produce.
DOI: 10.6084/m9.figshare.11678529
title: EVALUATION OF PREDICTIVE FACTORS OF IN HOSPITAL MORTALITY IN PATIENTS WITH PROXIMAL FEMORAL FRACTURE

description: ABSTRACT Objective: To investigate the existence of a causal association between orthopedic treatment and the occurrence of in hospital death. Methods: 338 patients with proximal femoral fracture were evaluated, of whom 27 faced in hospital death. Patients who faced in hospital death (case group) were compared to patients who did not (control group) regarding exposure to risk factors prior to injury and factors related to orthopedic treatment. Results: The factors related to higher in hospital mortality rate were: male sex (case group: 52%, control: 26%; p = 0.005), lower Parker’s score (case group: 5.0 points, control: 6.2; p = 0.048), delirium on admission (case group: 26%, control: 10%; p = 0.011); delirium developed during hospitalization (case group: 77%, control: 35%; p &lt;0.001), and time until surgery (13.3 days, 9.1; p = 0.049). Conclusion: The in hospital mortality rate of patients with proximal femoral fracture was 8%, and the main associated risk factors were male sex, reduced Parker’s score, delirium diagnosed on hospital admission or developed during hospitalization, and time until surgery. Level of Evidence III, Case control study.
DOI: 10.6084/m9.figshare.11678523
title: Rehabilitation through virtual reality: physical activity of patients admitted to the intensive care unit

description: ABSTRACT Objective: To evaluate the level of activity that Nintendo WiiTM can elicit in intensive care unit patients and its associated safety and patient satisfaction. Methods: Experimental, single-center study performed at a tertiary care hospital. Patients ≥ 18 years old who were admitted to the intensive care unit, participated in videogames as part of their physical therapy sessions and did not have mobility restrictions were included. Th exclusion criteria were the inability to comprehend instructions and the inability to follow simple commands. We included n = 60 patients and performed 100 sessions. We used the Nintendo WiiTM gaming system in the sessions. An accelerometer measured the level of physical activity of patients while they played videogames. We evaluated the level of activity, the modified Borg scale scores, the adverse events and the responses to a questionnaire on satisfaction with the activity. Results: One hundred physical therapy sessions were analyzed. When the patients played the videogame, they reached a light level of activity for 59% of the session duration and a moderate level of activity for 38% of the session duration. No adverse events occurred. A total of 86% of the patients reported that they would like to play the videogame in their future physical therapy sessions. Conclusion: Virtual rehabilitation elicited light to moderate levels of activity in intensive care unit patients. This therapy is a safe tool and is likely to be chosen by the patient during physical therapy.
DOI: 10.6084/m9.figshare.11678526.v1
title: Organic acids and hydrogen peroxide can replace chlorinated compounds as sanitizers on strawberries, cucumbers and rocket leaves

description: Abstract This work evaluated the effectiveness of 1 and 2% acetic and lactic acid, 3% hydrogen peroxide, 200 mg/L sodium hypochlorite and 200 mg/L sodium dichloroisocyanurate to reducing natural contaminants as well as Salmonella enterica Enteritidis inoculated on the surface of strawberries, cucumbers, and rocket leaves. The reduction of aerobic mesophilic and molds and yeasts was between 1.67 – 2.73 and 0.61 – 1.46 log CFU/g in strawberries, 1.48 – 2.19 and 1.02 – 2.01 log CFU/g on rocket leaves, and 1.10 – 2.08 and 0.88 – 1.58 log CFU/g in cucumbers, respectively. The most effective sanitizers for reducing Salmonella enterica Enteritidis in strawberries were 1% and 2% lactic acid, while in cucumbers and rocket leaves was the 2% lactic acid as well as the 3% hydrogen peroxide, for both samples. The results of this study clearly show the potential of the proposed strategies to replace chlorinated compounds in the sanitization step of fresh produce.
DOI: 10.6084/m9.figshare.11678523.v1
title: Rehabilitation through virtual reality: physical activity of patients admitted to the intensive care unit

description: ABSTRACT Objective: To evaluate the level of activity that Nintendo WiiTM can elicit in intensive care unit patients and its associated safety and patient satisfaction. Methods: Experimental, single-center study performed at a tertiary care hospital. Patients ≥ 18 years old who were admitted to the intensive care unit, participated in videogames as part of their physical therapy sessions and did not have mobility restrictions were included. Th exclusion criteria were the inability to comprehend instructions and the inability to follow simple commands. We included n = 60 patients and performed 100 sessions. We used the Nintendo WiiTM gaming system in the sessions. An accelerometer measured the level of physical activity of patients while they played videogames. We evaluated the level of activity, the modified Borg scale scores, the adverse events and the responses to a questionnaire on satisfaction with the activity. Results: One hundred physical therapy sessions were analyzed. When the patients played the videogame, they reached a light level of activity for 59% of the session duration and a moderate level of activity for 38% of the session duration. No adverse events occurred. A total of 86% of the patients reported that they would like to play the videogame in their future physical therapy sessions. Conclusion: Virtual rehabilitation elicited light to moderate levels of activity in intensive care unit patients. This therapy is a safe tool and is likely to be chosen by the patient during physical therapy.
DOI: 10.6084/m9.figshare.11678529.v1
title: EVALUATION OF PREDICTIVE FACTORS OF IN HOSPITAL MORTALITY IN PATIENTS WITH PROXIMAL FEMORAL FRACTURE

description: ABSTRACT Objective: To investigate the existence of a causal association between orthopedic treatment and the occurrence of in hospital death. Methods: 338 patients with proximal femoral fracture were evaluated, of whom 27 faced in hospital death. Patients who faced in hospital death (case group) were compared to patients who did not (control group) regarding exposure to risk factors prior to injury and factors related to orthopedic treatment. Results: The factors related to higher in hospital mortality rate were: male sex (case group: 52%, control: 26%; p = 0.005), lower Parker’s score (case group: 5.0 points, control: 6.2; p = 0.048), delirium on admission (case group: 26%, control: 10%; p = 0.011); delirium developed during hospitalization (case group: 77%, control: 35%; p &lt;0.001), and time until surgery (13.3 days, 9.1; p = 0.049). Conclusion: The in hospital mortality rate of patients with proximal femoral fracture was 8%, and the main associated risk factors were male sex, reduced Parker’s score, delirium diagnosed on hospital admission or developed during hospitalization, and time until surgery. Level of Evidence III, Case control study.
DOI: 10.6084/m9.figshare.11678517
title: Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy

description: Abstract Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration compromised the field of its advancement. Single chain variable fragments convention instead of the full-length antibody may overcome the challenge of rapid penetration and internalization. Programmed cell death ligand-1 interaction with PD-1 has recently revolutionized the field of immunotherapy. We systematically designed scPDL1-DM1 drug conjugate by linking scFv-PD-L1 proteins (scFv) with maytansinoids (DM1) cytotoxic agent through succinimidyl trans-4-maleimidylmethyl cyclohexane-1- carboxylate (SMCC) linker. Binding affinity was confirmed by immunocytochemistry, spectrophotometry and gel electrophoresis analysis. The scPDL1-DM1 showed specific binding with PD-L1 positive tumor cells and retained in vitro anti-cell proliferation activity. The intracellular trafficking of the drug was evaluated in A549 cancer cell lines, and maximum trafficking was observed after two hours of incubation. The generated drug can be utilized as a potent tool for site-specific conjugation, predicting specificity in vitro activities with extended range against PD-L1 positive cancer cells and can be utilized for further in vivo testing and clinical therapeutics development.
DOI: 10.6084/m9.figshare.11678520
title: Innovation in Emerging Economy Organizations

description: Abstract This special issue of Cadernos EBAPE.BR invites reflection around building a critical research agenda on the field of innovation strategies and organizations in emerging economies, considering the implications of such an agenda to the Brazilian academy. The published articles reveal the spectrum of upcoming interests of Brazilian researchers on this topic. The first group of articles focused on analyzing innovation policies aimed at SMEs, agriculture and mining, environmentally sensitive sectors, and the foundations of start-up ecosystems. The second group of articles focused on innovation in emerging markets, based on the approaches of frugality, social businesses, and the dynamics of organizational radicality. Finally, the articles published in this issue brought theoretical and practical contributions to the debate, discussing topics such as digital transformation, the industry 4.0 and its relevance to BRIC countries, and administration of smart cities and knowledge-intensive services.
DOI: 10.6084/m9.figshare.11678514
title: Growth Hormone insensitivity (Laron syndrome): Report of a new family and review of Brazilian patients

description: Abstract Laron’s syndrome (LS) is a rare genetic disorder characterized by insensitivity to growth hormone (GH). Up to the present time, over 70 mutations of GH receptor (GHR) gene have been identified leading to GH/insulin-like growth factor type 1 (IGF1) signaling pathway defect. The number of LS patients worldwide is unknown, as many are probably undiagnosed. We report two sibs from a consanguineous family from Minas Gerais, southeastern Brazil. The parents have three children. The older, a 4-years-old girl was 80.2 cm tall (-5.7 SDS height/age), and the youngest sister, aged 3 years, was 73.2 cm tall (-5.82 SDS height/age). Their clinical and biochemical features are typical of LS patients, such as high serum level of GH and low IGF1 concentrations. A homozygous c.1A&gt;T nucleotide substitution in GHR exon 2 in the probands’ samples was identified. Their parents and healthy sister are heterozygous for the same variant that abolishes the translation initiation codon of GHR. This mutation has not been reported in Brazilian patients and was previously associated with an LS phenotype in a single 29-year-old Spanish man. In addition to this case report, we summarize the main characteristics and molecular data of the 21 LS Brazilian patients who have been published to date.
DOI: 10.6084/m9.figshare.11678517.v1
title: Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy

description: Abstract Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration compromised the field of its advancement. Single chain variable fragments convention instead of the full-length antibody may overcome the challenge of rapid penetration and internalization. Programmed cell death ligand-1 interaction with PD-1 has recently revolutionized the field of immunotherapy. We systematically designed scPDL1-DM1 drug conjugate by linking scFv-PD-L1 proteins (scFv) with maytansinoids (DM1) cytotoxic agent through succinimidyl trans-4-maleimidylmethyl cyclohexane-1- carboxylate (SMCC) linker. Binding affinity was confirmed by immunocytochemistry, spectrophotometry and gel electrophoresis analysis. The scPDL1-DM1 showed specific binding with PD-L1 positive tumor cells and retained in vitro anti-cell proliferation activity. The intracellular trafficking of the drug was evaluated in A549 cancer cell lines, and maximum trafficking was observed after two hours of incubation. The generated drug can be utilized as a potent tool for site-specific conjugation, predicting specificity in vitro activities with extended range against PD-L1 positive cancer cells and can be utilized for further in vivo testing and clinical therapeutics development.
DOI: 10.6084/m9.figshare.11678520.v1
title: Innovation in Emerging Economy Organizations

description: Abstract This special issue of Cadernos EBAPE.BR invites reflection around building a critical research agenda on the field of innovation strategies and organizations in emerging economies, considering the implications of such an agenda to the Brazilian academy. The published articles reveal the spectrum of upcoming interests of Brazilian researchers on this topic. The first group of articles focused on analyzing innovation policies aimed at SMEs, agriculture and mining, environmentally sensitive sectors, and the foundations of start-up ecosystems. The second group of articles focused on innovation in emerging markets, based on the approaches of frugality, social businesses, and the dynamics of organizational radicality. Finally, the articles published in this issue brought theoretical and practical contributions to the debate, discussing topics such as digital transformation, the industry 4.0 and its relevance to BRIC countries, and administration of smart cities and knowledge-intensive services.
DOI: 10.6084/m9.figshare.11678511
title: A systematic review of smart cities and the internet of things as a research topic

description: Abstract This study aims to analyze the current academic literature on Smart Cities and the Internet of Things using bibliometric analysis and quantitative content analysis. It primarily consists of extracting data from the web-of-science: citations, languages, countries, most prolific authors, the most relevant works, keywords, institutions, conferences, and journals. Results confirm that the most preeminent literature on Smart Cities and the Internet of Things focuses on developed countries with a long tradition of innovation and IT research showing a similar pattern. From this analysis, limitations and opportunities for future studies are observed. A research agenda and suggestions for new theoretical questions were developed for scholars of Smart Cities and the Internet of Things.
DOI: 10.6084/m9.figshare.11678514.v1
title: Growth Hormone insensitivity (Laron syndrome): Report of a new family and review of Brazilian patients

description: Abstract Laron’s syndrome (LS) is a rare genetic disorder characterized by insensitivity to growth hormone (GH). Up to the present time, over 70 mutations of GH receptor (GHR) gene have been identified leading to GH/insulin-like growth factor type 1 (IGF1) signaling pathway defect. The number of LS patients worldwide is unknown, as many are probably undiagnosed. We report two sibs from a consanguineous family from Minas Gerais, southeastern Brazil. The parents have three children. The older, a 4-years-old girl was 80.2 cm tall (-5.7 SDS height/age), and the youngest sister, aged 3 years, was 73.2 cm tall (-5.82 SDS height/age). Their clinical and biochemical features are typical of LS patients, such as high serum level of GH and low IGF1 concentrations. A homozygous c.1A&gt;T nucleotide substitution in GHR exon 2 in the probands’ samples was identified. Their parents and healthy sister are heterozygous for the same variant that abolishes the translation initiation codon of GHR. This mutation has not been reported in Brazilian patients and was previously associated with an LS phenotype in a single 29-year-old Spanish man. In addition to this case report, we summarize the main characteristics and molecular data of the 21 LS Brazilian patients who have been published to date.
DOI: 10.6084/m9.figshare.11678508
title: Interaction of Fusarium solani, Macrophomina phaseolina and Rhizoctonia solani as root rot pathogens of Cucumis melo

description: ABSTRACT Root diseases represent one of the main reasons for yield loss in melon crops, especially root and stem rots caused by pathogens like the fungi Fusarium solani (Fs), Macrophomina phaseolina (Mp) and Rhizoctonia solani (Rs), frequently observed in muskmelon either alone or in combination. The objective of this study was to evaluate the effect of the interaction between the pathogens Fs, Mp and Rs on the incidence and severity of root rot and muskmelon development. Two greenhouse experiments were performed using plastic pots with substrate infested with each pathogenic agent alone or in combination. The second experiment was conducted in the same pots that were used in the first experiment. In the first experiment, the disease incidence was higher for the treatment with Fs alone. In the second experiment, the disease incidence and severity were greater for treatment Fs + Rs than for Fs alone. Macrophomina phaseolina was the most commonly isolated pathogen when applied to the plants in a paired mixed inoculum (Fs + Mp and Mp + Rs) in the first experiment. In the second experiment, Fs was more prevalent than the other studied pathogens. Soil infested with Fs had the lowest fresh weight of muskmelon. The pathogens Fs and Mp were more competitive than Rs.