cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28429094
title: Comparison of sterile normal saline and 1% povidone-iodine for vaginal preparation in vesicovaginal fistula: a randomised trial

description: Vaginal preparation before transvaginal gynecological surgeries improves the success rate. However, there is no consensus on which agent is superior for transvaginal repair of vesicovaginal fistula (VVF). We aimed to compare irritation symptoms and antimicrobial function between sterile normal saline (SS) and 1% povidone-iodine (PI) for vaginal preparation in surgical repair of VVF. This randomised, controlled trial was conducted on patients with VVF underwent transvaginal repair. Preoperative vaginal irrigation was randomly performed with either SS or 1% PI. The patients’ self-reported symptoms questionnaires, including numerical rating scale (NRS) of pain, Indevus urgency severity scale (IUSS), and vaginal symptoms, tissue edoema degree and pathogenic microbiology were recorded. The study included 30 patients in the SS group and 31 patients in the PI group. After twice irrigations before surgery, compared with the PI group, the SS group had a similar count of bacterial species but a higher bacterial load (<i>p</i> = .079 and <i>p</i> = .033). The NRS of pain and IUSS in the SS group were lower than those in the PI group (<i>p</i> &lt; .001). The SS group had less severe vaginal symptoms (<i>p</i> &lt; .001) and tissue edoema (<i>p</i> &lt; .001) than the PI group. The successful repair rates were 86.7% in the SS group and 83.9% in the PI group (<i>p</i> = .758). Patients with more severe urinary and vaginal symptoms had lower successful repair rates (92.3% vs. 72.7%, <i>p</i> = .047). SS is an effective vaginal preparation liquid for transvaginal repair of VVF with less irritation symptoms and acceptable antimicrobial function. Our study results suggest that the sterile normal saline is a considerable alternative in vaginal preparation for vesicovaginal fistula surgery. There was not significant difference on successful repair rate between the povidone-iodine group and the sterile normal saline group. Compared with the sterile normal saline group, the povidone-iodine group had more serious symptoms but similar bacterial load at lower urinary tract and vagina. Therefore, the sterile normal saline, as an acceptable irrigation liquid in vaginal preparation for vesicovaginal fistula repair.
DOI: 10.6084/m9.figshare.28429094.v1
title: Comparison of sterile normal saline and 1% povidone-iodine for vaginal preparation in vesicovaginal fistula: a randomised trial

description: Vaginal preparation before transvaginal gynecological surgeries improves the success rate. However, there is no consensus on which agent is superior for transvaginal repair of vesicovaginal fistula (VVF). We aimed to compare irritation symptoms and antimicrobial function between sterile normal saline (SS) and 1% povidone-iodine (PI) for vaginal preparation in surgical repair of VVF. This randomised, controlled trial was conducted on patients with VVF underwent transvaginal repair. Preoperative vaginal irrigation was randomly performed with either SS or 1% PI. The patients’ self-reported symptoms questionnaires, including numerical rating scale (NRS) of pain, Indevus urgency severity scale (IUSS), and vaginal symptoms, tissue edoema degree and pathogenic microbiology were recorded. The study included 30 patients in the SS group and 31 patients in the PI group. After twice irrigations before surgery, compared with the PI group, the SS group had a similar count of bacterial species but a higher bacterial load (<i>p</i> = .079 and <i>p</i> = .033). The NRS of pain and IUSS in the SS group were lower than those in the PI group (<i>p</i> &lt; .001). The SS group had less severe vaginal symptoms (<i>p</i> &lt; .001) and tissue edoema (<i>p</i> &lt; .001) than the PI group. The successful repair rates were 86.7% in the SS group and 83.9% in the PI group (<i>p</i> = .758). Patients with more severe urinary and vaginal symptoms had lower successful repair rates (92.3% vs. 72.7%, <i>p</i> = .047). SS is an effective vaginal preparation liquid for transvaginal repair of VVF with less irritation symptoms and acceptable antimicrobial function. Our study results suggest that the sterile normal saline is a considerable alternative in vaginal preparation for vesicovaginal fistula surgery. There was not significant difference on successful repair rate between the povidone-iodine group and the sterile normal saline group. Compared with the sterile normal saline group, the povidone-iodine group had more serious symptoms but similar bacterial load at lower urinary tract and vagina. Therefore, the sterile normal saline, as an acceptable irrigation liquid in vaginal preparation for vesicovaginal fistula repair.
DOI: 10.6084/m9.figshare.28776535
title: Association between secondhand smoke exposure and osteoporosis risk in postmenopausal women: a cross-sectional analysis of NHANES data

description: This study aimed to investigate the association between smoke exposure and the risk of osteoporosis in postmenopausal women in the United States, using data from the National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis was conducted using NHANES data from 2005 to 2010, 2013 to 2014, and 2017 to 2018. The study population consisted of postmenopausal women aged 18 years and older. Their bone health status was assessed using self-reported osteoporosis and dual-energy X-ray absorptiometry (DXA) measurements, smoke exposure was evaluated through serum cotinine levels, and multivariate logistic regression models were used to examine the association between smoke exposure and osteoporosis risk, adjusting for sociodemographic factors, health behaviours, and comorbidities. The analysis comprised 4,140 postmenopausal women, and data analysis showed that active smoking was significantly associated with an increased risk of osteoporosis, with an adjusted odds ratio (OR) of 2.020 (95% confidence interval [CI]: 1.35–3.03), after adjusting for potential confounders. Additionally, age, race/ethnicity, socioeconomic status, marital status, and body mass index were identified as significant predictors of osteoporosis risk. Smoke exposure, particularly active smoking, was associated with an elevated risk of osteoporosis among postmenopausal women in the United States. The findings underscore the need to address modifiable risk factors, such as smoking cessation, and implement targeted interventions to mitigate disparities in bone health. This study examined the relationship between smoke exposure and osteoporosis risk among postmenopausal women using data from NHANES. The findings show that active smoking significantly increased the likelihood of osteoporosis, even after adjusting for sociodemographic and health-related factors. In contrast, passive smoking had a weaker association with osteoporosis, and the analysis also identified additional predictors of osteoporosis risk, including age, race, socioeconomic status, and body mass index. Thus, interventions targeting modifiable risk factors, such as smoking cessation and addressing socioeconomic disparities, could help reduce osteoporosis risk in this vulnerable population, emphasising the need of raising awareness about bone health among postmenopausal women.
DOI: 10.6084/m9.figshare.28776535.v1
title: Association between secondhand smoke exposure and osteoporosis risk in postmenopausal women: a cross-sectional analysis of NHANES data

description: This study aimed to investigate the association between smoke exposure and the risk of osteoporosis in postmenopausal women in the United States, using data from the National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis was conducted using NHANES data from 2005 to 2010, 2013 to 2014, and 2017 to 2018. The study population consisted of postmenopausal women aged 18 years and older. Their bone health status was assessed using self-reported osteoporosis and dual-energy X-ray absorptiometry (DXA) measurements, smoke exposure was evaluated through serum cotinine levels, and multivariate logistic regression models were used to examine the association between smoke exposure and osteoporosis risk, adjusting for sociodemographic factors, health behaviours, and comorbidities. The analysis comprised 4,140 postmenopausal women, and data analysis showed that active smoking was significantly associated with an increased risk of osteoporosis, with an adjusted odds ratio (OR) of 2.020 (95% confidence interval [CI]: 1.35–3.03), after adjusting for potential confounders. Additionally, age, race/ethnicity, socioeconomic status, marital status, and body mass index were identified as significant predictors of osteoporosis risk. Smoke exposure, particularly active smoking, was associated with an elevated risk of osteoporosis among postmenopausal women in the United States. The findings underscore the need to address modifiable risk factors, such as smoking cessation, and implement targeted interventions to mitigate disparities in bone health. This study examined the relationship between smoke exposure and osteoporosis risk among postmenopausal women using data from NHANES. The findings show that active smoking significantly increased the likelihood of osteoporosis, even after adjusting for sociodemographic and health-related factors. In contrast, passive smoking had a weaker association with osteoporosis, and the analysis also identified additional predictors of osteoporosis risk, including age, race, socioeconomic status, and body mass index. Thus, interventions targeting modifiable risk factors, such as smoking cessation and addressing socioeconomic disparities, could help reduce osteoporosis risk in this vulnerable population, emphasising the need of raising awareness about bone health among postmenopausal women.
DOI: 10.48597/xh53-ufrc
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.48597/8eb8-h4jf
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.48597/8pp4-xd53
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.48597/bcd2-2an2
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.6084/m9.figshare.29038979
title: Relationship between gastrointestinal disturbances, blood lipid levels, inflammatory markers, and preterm birth

description: The challenging incidence of preterm birth, the underlying causes of preterm birth remain unclear. This study determined the relationship between disturbed gastrointestinal symptoms, inflammatory markers, blood lipid levels, and preterm birth. One hundred and twenty pregnant women with preterm labour were compared to 120 pregnant women with full-term deliveries. All subjects underwent lactose breath and serologic testing. The correlation between small intestinal bacterial overgrowth (SIBO)-positivity, gastrointestinal symptoms, inflammatory factors, and blood lipid metabolism and preterm birth was analysed using the Spearman method. SIBO, hydrogen, and methane levels were significantly higher in the preterm birth (PTB) group than the full-term birth (FTB) group at different time points (<i>P</i> &lt; 0.05); Levels of high-sensitivity C-reactive protein (hs-CRP) (3.95[2.70–5.77] vs. 2.47[1.45–3.83]), Interleukin (IL)-10 (3.05[2.27–4.33] vs. 2.09[1.04–3.47]), IL-6 (5.23[3.95–8.50] vs. 2.98[2.22–4.44]), tumour necrosis factor -alpha (TNF-α) (3.23[1.55–4.90] vs. 1.76[0.98–3.10]), total cholesterol (TC) (5.52[4.97–5.95] vs. 5.24[4.73–5.85]), and triglycerides (TG) (2.58[2.04–3.53] vs. 2.24[1.59–3.05]) were significantly higher in the PTB group than the FTB group (<i>P</i> &lt; 0.05). Abdominal distension (2.67[1.67–3.00] vs. 2.33[1.67–2.67]) and constipation (2.00[1.33–2.00] vs. 1.67[1.33–2.00]) scores were also markedly higher in the PTB group than the FTB group (<i>P</i> &lt; 0.05). Preterm birth was positively correlated with SIBO, TC, and TG levels. Additionally, SIBO was positively correlated with hs-CRP, IL-10, IL-6, and TNF-α levels, abdominal distension, and constipation (<i>P</i> &lt; 0.05). Logistic regression analysis found the close association between positive SIBO, biochemistry indicators and preterm birth. Gastrointestinal disturbances, hyperlipidaemia and SIBO-positivity are more likely to occur among pregnant women with preterm labour. Further research with a large sample size in multi-centers is needed to validate the results. This study aims to explore the relationship between small intestinal bacterial overgrowth, blood lipid levels, and premature birth between120 pregnant women with premature labour and 120 with full-term delivery. From the clinical data and laboratory tests results, this study finds that, women who experienced preterm labour are more likely to develop small intestinal bacterial overgrowth, which may contribute to premature delivery by inducing inflammatory responses and exacerbating gastrointestinal discomfort. Additionally, hyperlipidaemia increases the risk of preterm birth.
DOI: 10.6084/m9.figshare.29038979.v1
title: Relationship between gastrointestinal disturbances, blood lipid levels, inflammatory markers, and preterm birth

description: The challenging incidence of preterm birth, the underlying causes of preterm birth remain unclear. This study determined the relationship between disturbed gastrointestinal symptoms, inflammatory markers, blood lipid levels, and preterm birth. One hundred and twenty pregnant women with preterm labour were compared to 120 pregnant women with full-term deliveries. All subjects underwent lactose breath and serologic testing. The correlation between small intestinal bacterial overgrowth (SIBO)-positivity, gastrointestinal symptoms, inflammatory factors, and blood lipid metabolism and preterm birth was analysed using the Spearman method. SIBO, hydrogen, and methane levels were significantly higher in the preterm birth (PTB) group than the full-term birth (FTB) group at different time points (<i>P</i> &lt; 0.05); Levels of high-sensitivity C-reactive protein (hs-CRP) (3.95[2.70–5.77] vs. 2.47[1.45–3.83]), Interleukin (IL)-10 (3.05[2.27–4.33] vs. 2.09[1.04–3.47]), IL-6 (5.23[3.95–8.50] vs. 2.98[2.22–4.44]), tumour necrosis factor -alpha (TNF-α) (3.23[1.55–4.90] vs. 1.76[0.98–3.10]), total cholesterol (TC) (5.52[4.97–5.95] vs. 5.24[4.73–5.85]), and triglycerides (TG) (2.58[2.04–3.53] vs. 2.24[1.59–3.05]) were significantly higher in the PTB group than the FTB group (<i>P</i> &lt; 0.05). Abdominal distension (2.67[1.67–3.00] vs. 2.33[1.67–2.67]) and constipation (2.00[1.33–2.00] vs. 1.67[1.33–2.00]) scores were also markedly higher in the PTB group than the FTB group (<i>P</i> &lt; 0.05). Preterm birth was positively correlated with SIBO, TC, and TG levels. Additionally, SIBO was positively correlated with hs-CRP, IL-10, IL-6, and TNF-α levels, abdominal distension, and constipation (<i>P</i> &lt; 0.05). Logistic regression analysis found the close association between positive SIBO, biochemistry indicators and preterm birth. Gastrointestinal disturbances, hyperlipidaemia and SIBO-positivity are more likely to occur among pregnant women with preterm labour. Further research with a large sample size in multi-centers is needed to validate the results. This study aims to explore the relationship between small intestinal bacterial overgrowth, blood lipid levels, and premature birth between120 pregnant women with premature labour and 120 with full-term delivery. From the clinical data and laboratory tests results, this study finds that, women who experienced preterm labour are more likely to develop small intestinal bacterial overgrowth, which may contribute to premature delivery by inducing inflammatory responses and exacerbating gastrointestinal discomfort. Additionally, hyperlipidaemia increases the risk of preterm birth.
DOI: 10.48597/dumn-n3sp
title: Measurement of HCB at Pallas (Matorova)

description: Measurement of HCB at Pallas (Matorova)
DOI: 10.6084/m9.figshare.28327274
title: Role of B7H4 and Fas in regulation of trophoblast cells and development of pre-eclampsia: a cross-sectional study

description: This study aimed to investigate the role of B7H4 and Fas in pre-eclampsia (PE) occurrence and development and reveal its potential mechanisms. Thirty healthy individuals and 60 patients with PE were enrolled in the study. In addition, the clinical characteristics of all participants were collected, including age, gestational weeks at delivery, gestational time, number of births, systolic blood pressure, diastolic blood pressure and foetal weight. The chi-square test was used to evaluate differences in clinical characteristics between the high- and low-expression groups. The expression levels of B7H4 and Fas were analysed using western blotting and real-time quantitative polymerase chain reaction (RT-qPCR). The upstream regulators of B7H4 in trophoblasts were predicted and estimated using a luciferase reporter assay. The proliferation and motility of trophoblasts were assessed using CCK8 and transwell assays, respectively. B7H4 and Fas were upregulated in PE (<i>p</i> &lt; 0.05) and showed diagnostic potential with insufficient sensitivity and specificity [B7H4: area under curve (AUC) = 0.790, sensitivity = 65%, specificity = 83.33%; Fas: AUC = 0.717, sensitivity = 68.34%, specificity = 73.33%]. B7H4 and Fas were closely associated with increased blood pressure in patients with PE (<i>p</i> &lt; 0.05), and the combination of B7H4 and Fas increased the diagnostic efficacy (AUC = 0.864), sensitivity (73.33%) and specificity (86.67%). In trophoblast cells, miR-4319 negatively regulated B7H4 and Fas expression as well as cell proliferation, migration and invasion (<i>p</i> &lt; 0.05). Overexpression of B7H4 alleviated the inhibitory effects of miR-4319, which were reversed by Fas knockdown (<i>p</i> &lt; 0.05). miR-4319 mediates the progression of trophoblast progression by negatively regulating the expression of B7H4 and Fas. Therefore, B7H4 and Fas may serve as potential biomarkers for the prediction and treatment of PE. This study aimed to evaluate the significance of B7H4 and Fas in the occurrence and development of pre-eclampsia (PE) and to reveal its potential mechanism. We found that the upregulated B7H4 and Fas served as diagnostic biomarkers for PE, and their combination showed higher diagnostic efficacy, sensitivity and specificity. miR-4319 negatively regulates B7H4 and Fas in trophoblasts and therefore mediates cell proliferation, migration and invasion.
DOI: 10.6084/m9.figshare.28327274.v1
title: Role of B7H4 and Fas in regulation of trophoblast cells and development of pre-eclampsia: a cross-sectional study

description: This study aimed to investigate the role of B7H4 and Fas in pre-eclampsia (PE) occurrence and development and reveal its potential mechanisms. Thirty healthy individuals and 60 patients with PE were enrolled in the study. In addition, the clinical characteristics of all participants were collected, including age, gestational weeks at delivery, gestational time, number of births, systolic blood pressure, diastolic blood pressure and foetal weight. The chi-square test was used to evaluate differences in clinical characteristics between the high- and low-expression groups. The expression levels of B7H4 and Fas were analysed using western blotting and real-time quantitative polymerase chain reaction (RT-qPCR). The upstream regulators of B7H4 in trophoblasts were predicted and estimated using a luciferase reporter assay. The proliferation and motility of trophoblasts were assessed using CCK8 and transwell assays, respectively. B7H4 and Fas were upregulated in PE (<i>p</i> &lt; 0.05) and showed diagnostic potential with insufficient sensitivity and specificity [B7H4: area under curve (AUC) = 0.790, sensitivity = 65%, specificity = 83.33%; Fas: AUC = 0.717, sensitivity = 68.34%, specificity = 73.33%]. B7H4 and Fas were closely associated with increased blood pressure in patients with PE (<i>p</i> &lt; 0.05), and the combination of B7H4 and Fas increased the diagnostic efficacy (AUC = 0.864), sensitivity (73.33%) and specificity (86.67%). In trophoblast cells, miR-4319 negatively regulated B7H4 and Fas expression as well as cell proliferation, migration and invasion (<i>p</i> &lt; 0.05). Overexpression of B7H4 alleviated the inhibitory effects of miR-4319, which were reversed by Fas knockdown (<i>p</i> &lt; 0.05). miR-4319 mediates the progression of trophoblast progression by negatively regulating the expression of B7H4 and Fas. Therefore, B7H4 and Fas may serve as potential biomarkers for the prediction and treatment of PE. This study aimed to evaluate the significance of B7H4 and Fas in the occurrence and development of pre-eclampsia (PE) and to reveal its potential mechanism. We found that the upregulated B7H4 and Fas served as diagnostic biomarkers for PE, and their combination showed higher diagnostic efficacy, sensitivity and specificity. miR-4319 negatively regulates B7H4 and Fas in trophoblasts and therefore mediates cell proliferation, migration and invasion.
DOI: 10.6084/m9.figshare.29071937
title: Chronic hepatitis B infection and pre-eclampsia/eclampsia: a Mendelian randomisation study

description: This study aimed to investigate the potential causal association between chronic hepatitis B (CHB) infection and the risk of pre-eclampsia/eclampsia using a Mendelian randomisation (MR) design. We conducted a two-sample MR analysis using genome-wide association study (GWAS) summary statistics from three large-scale datasets. For CHB infection, we used data from 351,885 individuals UK Biobank. For pre‑eclampsia/eclampsia, we analysed two FinnGen datasets with sample sizes of 118,291 and 126,760 individuals, respectively. Genetic variants strongly associated with CHB infection (<i>p</i> &lt; 5 × 10<sup>−8</sup>) were selected as instrumental variables. The inverse-variance weighted (IVW) method was employed as the primary analysis. Sensitivity analyses included MR-Egger regression, weighted median, weighted mode and MR-PRESSO. Cochran’s <i>Q</i> test and MR-Egger intercept tests were performed to assess heterogeneity and horizontal pleiotropy, respectively. MR analysis revealed significant positive genetic associations between CHB infection and increased risk of pre-eclampsia (OR = 1.154, 95%CI = 1.014–1.313, <i>p</i> = .029) and eclampsia (OR = 1.561, 95%CI = 1.030–2.366, <i>p</i> = .035). Findings were robust across sensitivity analyses for both outcomes. Our study provides genetic evidence that CHB infection increases the risk of both pre-eclampsia and eclampsia. These findings suggest that considering CHB status as a risk factor and implementing targeted HBV screening programmes may be beneficial for pregnant women. This study explored the link between long-term hepatitis B infection (chronic hepatitis B, CHB) and two serious pregnancy complications: pre-eclampsia and eclampsia. Chronic hepatitis B is a persistent liver infection. Pre-eclampsia and eclampsia cause high blood pressure in pregnant women; eclampsia also involves seizures, posing risks to both mother and baby. We used genetic information to investigate whether having a higher genetic chance of getting CHB also increases the risk of developing these pregnancy problems. Our results consistently show that women with a genetic predisposition to CHB infection appear to have a higher risk of developing both pre-eclampsia and eclampsia. This suggests that being aware of a woman’s hepatitis B status during pregnancy could be important. Close monitoring for early signs of pre-eclampsia or eclampsia might be beneficial for pregnant women with CHB to help ensure their safety and the health of their baby.