cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19614589.v1
title: Surface fit script from The hamstrings: quadriceps functional ratio expressed over the full angle-angular velocity range using a limited number of data points

description: This script fits the Re function to the raw ratio points obtained with the Raw_Ratio_Points fit. The current example demonstrates the fit on 17 raw ratio points
DOI: 10.25345/c5cc0tx74
title: MassIVE MSV000089307 - HT-29 mouse xenograft mediated proteomic profiling of metabolic proteins as potential biomarkers of radioresponsiveness for colorectal cancer
title: Using a mouse model inoculated with human CRC cells (HT-29-Red-Fluc), we have shortlisted some specific metabolic proteins that are differentially expressed in tumours that responded well to radiation treatment.
DOI: 10.25345/c57p8th65
title: MassIVE MSV000089308 - The highly potent AhR agonist Picoberin modulates Hh-dependent osteoblast differentiation
title: Global proteome profiling. C3H10T1/2 cells were treated with 1.5microM purmorphamine and 1 nM of Picoberin or DMSO as a control. Cell lysates were collected after 0 h, 24 h, 48 h, 96 h or 7 days and subjected to MS/MS analysis to quantify global protein levels.
DOI: 10.6084/m9.figshare.19646544
title: Supplementary Material for: Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-κB Axis in a YTHDF2-Dependent Manner

description: <b><i>Introduction:</i></b> Senescent cells play a key role in the initiation and development of various age-related diseases. Human umbilical vein endothelial cells (HUVECs) senescence is closely associated with age-related cardiovascular diseases. Accumulating evidence has demonstrated that senolytics, the combination of dasatinib and quercetin (D+Q), could selectively eliminate senescent cells. N6-methyladenosine (m6A), the most abundant internal transcript modification, greatly influences RNA metabolism and modulates gene expression. We aimed to investigate whether RNA m6A functions in lipopolysaccharide (LPS)-induced HUVECs senescence and D+Q suppress HUVECs senescence by regulating RNA m6A. <b><i>Methods:</i></b> Senescence-associated β-galactosidase activity, western blot, and real-time quantitative polymerase chain reaction were performed to demonstrate that D+Q suppress HUVECs senescence. Methylated RNA immunoprecipitation (MeRIP)-qPCR assay and RIP-qPCR confirmed that RNA m6A plays a key role in the suppression of HUVECs senescence by D+Q. Chromatin immunoprecipitation and mRNA stability assay were carried out to prove that D+Q alleviate HUVECs senescence in a YTHDF2-dependent manner. <b><i>Results:</i></b> Here, we demonstrate that D+Q alleviate LPS-induced senescence in HUVECs via inhibiting autocrine and paracrine of the senescence-associated secretory phenotype (SASP). We further confirm that D+Q alleviate HUVECs senescence via the TNF receptor-associated factor 6 (TRAF6)-MAPK pathway. Mechanically, this study validates that D+Q suppress SASP by upregulating m6A reader YTHDF2. Besides, YTHDF2 regulates the stability of MAP2K4 and MAP4K4 mRNAs. <b><i>Conclusion:</i></b> Collectively, we first identified that D+Q alleviate LPS-induced senescence in HUVECs via the TRAF6-MAPK-NF-κB axis in a YTHDF2-dependent manner, providing novel ideas for clinical treatment of age-related cardiovascular diseases.
DOI: 10.34740/kaggle/dsv/3524312
title: Health Workforce Shortage Areas
DOI: 10.6084/m9.figshare.19645140
title: Supplementary Material for: Discrepancy between Guidelines and Clinical Practice in the Management of Cow’s Milk Allergy in Children: An Online Cross-Sectional Survey of Polish Physicians

description: The aim of this study was to assess the compliance between current guidelines on the diagnosis and management of children with cow’s milk allergy (CMA) and clinical practice by a survey of Polish physicians. An online cross-sectional survey involving a convenience series of participants was performed from January 15 to March 20, 2020. Data provided by 605 physicians (74.2% of them pediatricians working in general practice) were analyzed. Contrary to the current recommendations, only a minority of respondents (27.4%) reported performing oral food challenge (OFC) to confirm the diagnosis of CMA. Among those who reported performing OFC (<i>n</i> = 160 respondents), the majority performed an open challenge (82.5%). Most respondents (79.2%) correctly recommended as the first-line treatment extensively hydrolyzed cow’s milk formula for a child with mild-to-moderate CMA. Less than half of participants (43.8%) recommended amino acid-based formula for a child with severe CMA (anaphylaxis). Only half of respondents (50.8%) reassessed tolerance to cow’s milk proteins. For assessing tolerance acquisition, more respondents recommended challenge to baked milk compared with fresh cow’s milk (60.5% vs. 39.5%, respectively). This survey study found that only a minority of responding physicians follow current guidelines for diagnosis and management of children with CMA in Poland.
DOI: 10.6084/m9.figshare.19344932
title: Supplementary Material for: Treatment Patterns, Safety, and Patient Reported Outcomes among Adult Women with Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer with or without or with Unknown BRCA1/2 Mutation(s): Results of a Real-World Study from the United States, United Kingdom, and Four EU Countries

description: Introduction: This real-world study assessed the breast cancer susceptibility gene 1 or 2 mutation (BRCA1/2mut) status on treatment patterns, safety, and patient-reported outcomes (PROs) in women with human epidermal growth factor receptor 2–negative (HER2-) advanced breast cancer (ABC) in the United States, United Kingdom, and EU4 countries. Methods: Oncologists abstracted data from medical charts of adult women who presented with HER2– ABC from February to May 2015 and from March to July 2017. Data were collected using a physician-reported form and a patient-reported form, which included questions on breast cancer history/treatment, and questions from PROs instruments (EuroQol 5-Dimensions 3-Levels [EQ-5D-3L], Brief Pain Inventory [BPI], European Organisation for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire Core 30 and its breast cancer module). Results: In total, 742 oncologists provided data for 6161 patients; 27.5% were tested for BRCA1/2mut. Out of the total patient population, 3.8% had BRCA1/2mut, 16.6% BRCA1/2 wild-type (BRCA1/2wt), and 79.5% were BRCA1/2 unknown (BRCA1/2unk). Hormone receptor-positive (HR+)/HER2- ABC was more frequent within the BRCA1/2wt versus BRCA1/2mut group, and triple-negative breast cancer (TNBC) within the BRCA1/2mut versus BRCA1/2wt group. More patients with HR+/HER2- ABC with BRCA1/2mut received chemotherapy (with or without targeted or endocrine therapy) versus BRCA1/2wt (66.0% vs 50.4%; p&lt;0.01); more patients had ≥1 AE (58.0% vs 39.1%; p&lt;0.001). Among patients with BRCA1/2mut versus BCRA1/2wt, a significantly higher proportion had some problems or worse in pain discomfort (p=0.021) and anxiety/depression (p=0.007) as measured by the EQ-5D-3L; role functioning (p&lt;0.01) and dyspnea (p&lt;0.05) measured by EORTC were worse with BRCA1/2mut. Pain scores by BPI were similar between groups. Conclusions: In patients with HER2- ABC in the real-world setting, more patients with BRCA1/2mut had TNBC, received chemotherapy, had &gt;1 AE, and experienced increased discomfort, anxiety, and dyspnea and diminished role functioning versus patients with BRCA1/2wt.
DOI: 10.6084/m9.figshare.19455866
title: Supplementary Material for: Subtype Classification of Intrahepatic Cholangiocarcinoma Using Liver MR imaging Features and its Prognostic Value

description: Introduction: Small duct (SD) and large duct (LD) subtypes of cholangiocarcinoma have been investigated for their prognostic factors. This study aimed to evaluate the diagnostic value of liver magnetic resonance imaging (MRI) in differentiating SD- and LD-types of intrahepatic cholangiocarcinoma (iCCA) and its prognostic value in predicting survival outcomes. Methods: One-hundred forty patients with surgically confirmed iCCAs (93 SD-type and 47 LD-type) who had available preoperative gadoxetic acid-enhanced liver MR images were retrospectively included. MRI features suggestive of LD-type over SD-type were analyzed using multivariate logistic analyses. Postoperative recurrence-free survival (RFS) and overall survival (OS) for 107 patients with available survival data were compared according to MRI features. Results: MRI features suggestive of LD-type included infiltrative contour (odds ratio [OR] 14.2, 95% confidence interval [CI]: 2.5 – 81.7, p = 0.003), diffuse biliary dilatation (OR 9.7, 95% CI: 1.2 – 76.9, p = 0.032), no arterial phase hyperenhancement (OR 17.8, 95% CI: 2.7 – 118.6, p = 0.003), and vascular invasion (OR 4.5, 95% CI: 1.3 – 15.4, p = 0.018). When two or more features were combined, sensitivity was 59.6% (28/47) and specificity was 95.7% (89/93) in discriminating the LD-type. RFS/OS was significantly shorter in patients with two or more MRI features, compared to those with none or one (310 days versus 529 days, p = 0.011/964 days versus 2023 days, p=0.010). Conclusions: Preoperative liver MRI may help predict the pathologic subtype of iCCAs as either the SD-type or LD-type, allowing preoperative identification of patients with poorer survival outcomes.
DOI: 10.6084/m9.figshare.19455866.v1
title: Supplementary Material for: Subtype Classification of Intrahepatic Cholangiocarcinoma Using Liver MR imaging Features and its Prognostic Value

description: Introduction: Small duct (SD) and large duct (LD) subtypes of cholangiocarcinoma have been investigated for their prognostic factors. This study aimed to evaluate the diagnostic value of liver magnetic resonance imaging (MRI) in differentiating SD- and LD-types of intrahepatic cholangiocarcinoma (iCCA) and its prognostic value in predicting survival outcomes. Methods: One-hundred forty patients with surgically confirmed iCCAs (93 SD-type and 47 LD-type) who had available preoperative gadoxetic acid-enhanced liver MR images were retrospectively included. MRI features suggestive of LD-type over SD-type were analyzed using multivariate logistic analyses. Postoperative recurrence-free survival (RFS) and overall survival (OS) for 107 patients with available survival data were compared according to MRI features. Results: MRI features suggestive of LD-type included infiltrative contour (odds ratio [OR] 14.2, 95% confidence interval [CI]: 2.5 – 81.7, p = 0.003), diffuse biliary dilatation (OR 9.7, 95% CI: 1.2 – 76.9, p = 0.032), no arterial phase hyperenhancement (OR 17.8, 95% CI: 2.7 – 118.6, p = 0.003), and vascular invasion (OR 4.5, 95% CI: 1.3 – 15.4, p = 0.018). When two or more features were combined, sensitivity was 59.6% (28/47) and specificity was 95.7% (89/93) in discriminating the LD-type. RFS/OS was significantly shorter in patients with two or more MRI features, compared to those with none or one (310 days versus 529 days, p = 0.011/964 days versus 2023 days, p=0.010). Conclusions: Preoperative liver MRI may help predict the pathologic subtype of iCCAs as either the SD-type or LD-type, allowing preoperative identification of patients with poorer survival outcomes.
DOI: 10.6084/m9.figshare.19634665
title: Table S8 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics <i>Heliconius erato</i> and <i>Heliconius melpomene.</i> Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in <i>H. erato</i> but not <i>H. melpomene.</i> We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
DOI: 10.6084/m9.figshare.19634665.v1
title: Table S8 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics <i>Heliconius erato</i> and <i>Heliconius melpomene.</i> Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in <i>H. erato</i> but not <i>H. melpomene.</i> We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
DOI: 10.6084/m9.figshare.19634671
title: Table S10 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics <i>Heliconius erato</i> and <i>Heliconius melpomene.</i> Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in <i>H. erato</i> but not <i>H. melpomene.</i> We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
DOI: 10.6084/m9.figshare.19634671.v1
title: Table S10 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics <i>Heliconius erato</i> and <i>Heliconius melpomene.</i> Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in <i>H. erato</i> but not <i>H. melpomene.</i> We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
DOI: 10.6084/m9.figshare.19634674.v1
title: Table S6 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Genes differentially expressed (FDR&lt;0.2) between H. erato cyrbia and H. erato demophoon at 7 DPP
DOI: 10.6084/m9.figshare.19634674
title: Table S6 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Genes differentially expressed (FDR&lt;0.2) between H. erato cyrbia and H. erato demophoon at 7 DPP
DOI: 10.6084/m9.figshare.19634677
title: Table S9 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics <i>Heliconius erato</i> and <i>Heliconius melpomene.</i> Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in <i>H. erato</i> but not <i>H. melpomene.</i> We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
DOI: 10.6084/m9.figshare.19634677.v1
title: Table S9 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics <i>Heliconius erato</i> and <i>Heliconius melpomene.</i> Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in <i>H. erato</i> but not <i>H. melpomene.</i> We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
DOI: 10.6084/m9.figshare.19634680
title: Table S5 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Genes differentially expressed (FDR&lt;0.2) between H. erato cyrbia and H. erato demophoon at 5 days post-pupation (DPP)
DOI: 10.6084/m9.figshare.19634680.v1
title: Table S5 from The genetic basis of structural colour variation in mimetic <i>Heliconius</i> butterflies

description: Genes differentially expressed (FDR&lt;0.2) between H. erato cyrbia and H. erato demophoon at 5 days post-pupation (DPP)