cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/2wf7yfzgr5.1
title: SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray

description: There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is spread by respiratory droplets and thus effective, scalable and safe preventive interventions are urgently needed. We hypothesise that preventing viral entry into mammalian nasal epithelial cells may be one way to limit the spread of COVID-19. Here we show that N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ), a positively charged polymer that has been through an extensive Good Laboratory Practice toxicology screen, is able to reduce the infectivity of SARS-COV-2 in A549ACE2+ and Vero E6 cells with a log removal value of -3 to -4 at a concentration of 10 – 100 g/ mL (p &lt; 0.05 compared to untreated controls) and to limit infectivity in human airway epithelial cells at a concentration of 500 g/ mL (p &lt; 0.05 compared to untreated controls). GCPQ is currently being developed as a pharmaceutical excipient in nasal and ocular formulations. GCPQ’s electrostatic binding to the virus, preventing viral entry into the host cells, is the most likely mechanism of viral inhibition. Radiolabelled GCPQ studies in mice show that at a dose of 10 mg/ kg, GCPQ has a long residence time in mouse nares, with 13.1% of the injected dose identified from SPECT/CT in the nares, 24 hours after nasal dosing. With a no observed adverse effect level of 18 mg/ kg in rats, following a 28-day repeat dose study, clinical testing of this polymer, as a COVID-19 prophylactic is warranted.
DOI: 10.17632/5wpcrnkvc7.1
title: Selection-driven tumor evolution involving non-cell growth promotion leads to patterns of clonal expansion consistent with neutrality interpretation. Edwards et al.

description: This contains the data used to produce the figures in the publication: https://doi.org/10.1016/j.isci.2020.101901. This data is reproducible from the model files located at https://github.com/jackedwards1/CE_ABM.
DOI: 10.17632/pjcc8z6fpc.1
title: Mantzaouras Nikos

description: THEME "Τhe Riemann Hypothesis and distribution of the primes" Abstract: The Riemann zeta function is one of the most Euler’s important and fascinating functions in mathematics. By analyzing the material of Riemann’s conjecture, we divide our analysis in the ζ(z) function and in the proof of the conjecture, which has very important consequences on the distribution of prime numbers. The proof of the Hypothesis of Riemann result from the simple logic, that when two properties are associated, (the resulting equations that based in two Functional equations of Riemann ), if zero these equations, ie ζ(z) = ζ (1-z)= 0 and simultaneously they to have the proved property 1-1 of the Riemann function ζ(z).Thus, there is not margin for to non exist the Re (z) = 1/2 {because ζ (z) = ζ (1-z)=0 and also ζ(z) as and ζ(1-z) are 1-1}.This, as it stands, will gives the direction of all the non-trivial roots to be all in on the critical line, with a value in the real axis equal 1/2.
DOI: 10.17632/g5k7tndk77.1
title: Exergoeconomic Analysis

description: Exergoeconomic analysis of basic Brayton cycle based cryocooler for 10 kW cooling load
DOI: 10.17632/hzptwk77r6.1
title: LINF_040017250

description: hypothetical protein; Leishmania infantum
DOI: 10.17632/mf8rbjzwmw.1
title: Constants of anisotropic elasticity up to the 6th order of nonlinearity: rotational transformations, symmetries, and averages for all crystal classes, isotropy, and transverse isotropy

description: Symbolically computed expressions for high-order nonlinear anisotropic elastic constants in the Voigt notation (linear 2nd-order constants cij, and non-linear orders from 3 to 6: cijk, cijkl, cijklm, cijklmn, where i,j,k,l,m,n = 1,...,6, and only unique components with i&lt;=j&lt;=k&lt;=l&lt;=m&lt;=n are considered). The dataset consists of: Appendix A: Symmetry relationships between the constants for all 32 crystal classes (falling into only 11 distinctive Laue classes because of even rank of tensors of elastic constants), as well as for 2 non-crystalline symmetries: isotropic and transversely-isotropic (cylindrical). Appendix B: Rotational averages of the generally anisotropic constants to any of the symmetries mentioned above (a generalization of the Voigt average to nonlinearity and to goal symmetries other than isotropic). This can be used to reduce the number of constants by approximating low-symmetry materials with higher symmetry. Appendix C: Transformations of the constants under arbitrary rotation of the system of coordinates with the rotation matrix R with elements Rij, where i,j = 1,2,3.
DOI: 10.17632/5mt97xcyyw.1
title: Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid by Heming et al.
DOI: 10.17632/h338h7jvx9.1
title: Surgical strike and Indian newspapers

description: the researcher considered the first 14 days of coverage about the surgical strike starting from 29 September 2016. In this period, 114 articles appeared on Times of India (ToI), 102 in The Hindu (TH), and 29 in The Wire (TW) It has to be noted that the number of articles in TW seems to be smaller, but each story had multiple updates on the same day and other days for a few. Accounting for these updates, the total number of stories shall double the face count (which is around 60). A traditional newspaper has its limitation in extending the story as it receives updates on further developments. In contrast, a digital platform needs to hit the update button instantly. Hence, an initial short story updated at 6 in the morning on TW becomes a longer story by afternoon with as many updates as possible. A keyword, 'strike' anywhere in the story, including the headlines, has been considered in choosing the articles. The entire edition has been considered from the cover page to the sports page in all three news sources. An entire article's assertion has been considered for the study (Wimmer and Dominick, 2010). The study employs a descriptive content analysis with a codebook developed based on much research on a similar theme. The coding of each word has been studied empirically, and familiar themes are noted for each article. The codes employed in the study are drawn and revised from the study conducted by Jesper Falkheimer and Eva-Karin Olsson's paper on 2011's Norway's terrorist attack. Four parameters, Type of article, Journalistic Style, Framing, and Stance, are analyzed in analyzing the news items.
DOI: 10.17632/rtcympc7tm.1
title: Eimeria species and OTU sporulated oocysts
DOI: 10.17632/hftdsj2x4z.1
title: Telerehabilitation Cerebral Palsy

description: This data refers to mean, standard deviation and confidence interval of accuracy, precision, percentage of hits and rating of perceived exertion intelerehabilitation using non-immersive virtual reality serious games during quarantine for COVID-19 in people with Cerebral Palsy and Typically Developing peers. We hypothesize that all participants would be able to present performance improvement (assessed through the game), with increases in physical activity intensity levels (assessed through rating of perceived exertion -RPE- scale) and motivation (assessed through visual analogue scale –(VAS) scale for satisfaction and motivation). However, considering all the sensorimotor difficulties that characterize CP, the improvements and benefits will be more evident for the TD group. Our initial hypothesis was partially supported as all participants were able to engage with the therapy remotely and demonstrated improved performance, increasing their physical activity in this cross-sectional study, providing a positive base for developing HBTR in this group. However contrary to our hypothesis the TD group did not present better motor performance in all aspects of the protocol compared to the CP group opening opportunities for motivating competitions with TD peers and siblings. These results will be explained below.
DOI: 10.17632/x2vrsxzw7f.1
title: T21 brain single cell atlas

description: supplementary tables of Single cell atlas of trisomy 21 frontal cortex Supplementary Table 1. Markers of each cluster in frontal cortex. Supplementary Table 2. Enriched GO terms of each cluster in frontal cortex. Supplementary Table 3. DEGs of sub-trajectorys (T1_NPC and T2_NPC) and enriched GO terms. Supplementary Table 4. Ligand and receptor pairs of all clusters in frontal cortex. Supplementary Table 5. Enriched GO terms of targets of cluster specific TFs. Supplementary Table 6. Sample information and quality control of library.
DOI: 10.17632/zhmbx3v6zd.1
title: Angular Disparity of Isomorphic 2D and 3D Objects: Exploring Saccadic Characteristics in Mental Rotation

description: 1. Main file folder “Data Set” has three sub-folders naming- a) Eye-tracking data b) Game performance data c) NASA TLX data 2. Each sub-folder has further four sub-folders representing four groups’ with 30 samples in each, i.e. a) CA, i.e., convex angular disparity) b) RA, i.e., reflex angular disparity) c) 2D, i.e., two-dimensional objects) d) 3D, i.e., three-dimensional objects) ● CA: contains the data recorded during the MR computer-game with the objects with convex angular disparity. ● RA: contains the data recorded during the MR computer-game with the objects with reflex angular disparity. ● 2D: contains the data recorded during the MR computer-game with the two-dimensional objects. ● 3D: contains the data recorded during the MR computer-game with the three-dimensional objects. 2. Used software and instruments: Software: A) Unity3D Game Engine https://unity.com/ B) Blender Python API https://www.blender.org/ C) Tobii Studio (version 3.3.2) D) NASA TLX (version 1.0.1) https://play.google.com/store/apps/details?id=org.texoft.nasa_tlx E) MATLAB®️ (MathWorks, USA) (version: 2010b) F) SPSS®️ (IBM Corporation, USA) (Version 22, 2013) Instrument: Tobii TX 300, Stim Tracker, Acquisition computer.
DOI: 10.17632/m3zjf8z286.3
title: Bubble Image Database

description: Collection of the Bubble images: Bubbles were generated inside the column and bubble images were taken with a bubble viewer. All images were manually classified into five classes according to the gas dispersion states. # Class 1: Fine bubbles fully covering the viewing window # Class 2: Fine bubbles partially covering the viewing window # Class 3: Co-exit of coarse and fine bubbles # Class 4: Only coarse bubbles # Class 5: No bubbles Training set contains in total 5184 original images and 25920 augumented images. Test set contains 582 original images.
DOI: 10.17632/w6cxr8yc7p.1
title: Boğaziçi University Mouse Dynamics Dataset
DOI: 10.17632/ts44bfg45k.1
title: IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing_images_depository

description: Our previous studies have shown that IWS1 (Interacts with Spt6) is a phosphorylation target of Akt and regulates the alternative RNA splicing of FGFR-2, linking IWS1 with lung cancer tumorigenesis. To further address the role of IWS1 in alternative RNA splicing and lung cancer, we performed an RNA-seq study using lung adenocarcinoma cells in which IWS1 was knocked down or replaced by its phosphorylation site mutant. This identified the splicing factor U2 Associated-Factor 2 (U2AF2) as a target of IWS1 phosphorylation, by showing that the loss of phosphorylated IWS1 results in U2AF2 transcripts lacking exon 2. Exon 2 encodes part of the U2AF65 Serine-Rich (SR) Domain, which is required for its binding with pre-mRNA Processing factor 19 (Prp19). Here, we show that the loss of phosphorylated IWS1 interferes with histone H3K36 trimethylation and the assembly of LEDGF/SRSF1 splicing complexes on the U2AF2 gene in a cell-cycle specific manner. The latter results in the downregulation of cell cycle division associated 5 (CDCA5), a phosphorylation target of ERK, leading to impaired cell proliferation, G2/M phase arrest and impaired tumor growth in mouse xenografts models, an effect more pronounced in cells harboring EGFR mutations. Analysis of human lung adenocarcinoma samples reveals robust correlations between IWS1 phosphorylation, U2AF2 splicing pattern, and CDCA5/p-ERK levels, especially in EGFR mutated patients. More importantly, IWS1 phosphorylation is positively correlated with tumor stage and grade and defines poor prognosis in lung adenocarcinoma patients, harboring EGFR, and not KRAS, mutations. This work highlights the instrumental role of the AKT/p-IWS1 axis to alternative RNA splicing in governing cell cycle progression and tumorigenesis, and proposes this axis as a novel drug target and prognosis factor in lung adenocarcinoma, by concomitantly affecting the epigenetic regulation of RNA processing and oncogenic signals. These data accompany the main dataset of our paper : doi: 10.17632/y82yx8gfkj.3 In this dataset, we will upload all the images from cell transformation assays and IHC from mouse xenografts and human samples.
DOI: 10.17632/y82yx8gfkj.3
title: IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.

description: Our previous studies have shown that IWS1 (Interacts with Spt6) is a phosphorylation target of Akt and regulates the alternative RNA splicing of FGFR2, linking IWS1 with lung cancer tumorigenesis. To further address the role of IWS1 in alternative RNA splicing and lung cancer, we performed an RNA-seq study using lung adenocarcinoma cells in which IWS1 was knocked down or replaced by its phosphorylation site mutant. This identified the splicing factor U2 Associated-Factor 2 (U2AF2) as a target of IWS1 phosphorylation, by showing that the loss of phosphorylated IWS1 results in U2AF2 transcripts lacking exon 2. Exon 2 encodes part of the U2AF65 Serine-Rich (SR) Domain, which is required for its binding with pre-mRNA Processing factor 19 (Prp19). Here, we show that the loss of phosphorylated IWS1 interferes with histone H3K36 trimethylation and the assembly of LEDGF/SRSF1 splicing complexes on the U2AF2 gene in a cell-cycle specific manner. The latter results in the downregulation of cell cycle division associated 5 (CDCA5), a phosphorylation target of ERK, leading to impaired cell proliferation, G2/M phase arrest and impaired tumor growth in mouse xenografts models, an effect more pronounced in cells harboring EGFR mutations. Analysis of human lung adenocarcinoma samples reveals robust correlations between IWS1 phosphorylation, U2AF2 splicing pattern, and CDCA5/p-ERK levels, especially in EGFR mutated patients. More importantly, IWS1 phosphorylation is positively correlated with tumor stage and grade and defines poor prognosis in lung adenocarcinoma patients, harboring EGFR, and not KRAS, mutations. This work highlights the instrumental role of the AKT/p-IWS1 axis to alternative RNA splicing in governing cell cycle progression and tumorigenesis, and proposes this axis as a novel drug target and prognosis factor in lung adenocarcinoma, by concomitantly affecting the epigenetic regulation of RNA processing and oncogenic signals. The purpose of this database is to provide all the raw data materials that have led to the conclusions shown in this report. These materials include Western blotting images, PCR images, qPCR raw data and any other raw data material from resources such as plate readers. The cell imaging from IHC and cell cultures will be included in a separate dataset due to size. Along with that, the complete lab book from the whole process will be provided, showing all the procedures followed during the analysis.
DOI: 10.17632/yjrgv5fhhm.1
title: FTIR maps and profiles for CO2-rich diamonds

description: FTIR maps and profiles for CO2-rich diamonds. All details are in the folders.
DOI: 10.17632/wx7v7rmg7h.1
title: Installation Unit - REGISTOS DE BAPTISMOS

description: A CIDOC-CRM Ontology Representation of the Portuguese Archival Description Unit, entitled "Registos de baptimos" (http://pesquisa.adporto.arquivos.pt/details?id=488469), an Installation Unit with Reference Code "PT/ADPRT/PRQ/PPRT01/001/0004". This dataset is part of the results obtained from the semantic migration process of DigitArq - Portuguese Archive Database - metadata into CIDOC-CRM Ontology representation. This work is done in the context of the R&D EPISA project (Entity and Property Inference for Semantic Archives), a research project financed by National Funds through the Portuguese funding agency, FCT (Fundação para a Ciência e a Tecnologia) - DSAIPA/DS/0023/2018.
DOI: 10.17632/53yyysbsf9.1
title: Konstantinidis et al_folate secretion
DOI: 10.17632/96nzdf5s88.1
title: Supp Material Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells

description: Supplementary Material to "Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells"
DOI: 10.17632/6t42tbtzz5.3
title: Therapeutic response monitoring after targeted therapy in an orthotopic rat model of hepatocellular carcinoma using contrast-enhanced ultrasound: focusing on inter-scanner, and inter-operator reproducibility

description: The aim of this study was to assess therapeutic response monitoring after anti-angiogenic therapy in an orthotopic rat model of hepatocellular carcinoma (HCC) using CEUS with focusing on inter-scanner and inter-operator reproducibility. For reproducibility, CEUS was performed using two different US scanners by two operators in sixteen rat models of HCC. Using perfusion analysis software (VueBox ®), eleven parameters were collected, and intra-class correlation coefficient (ICC) was used to analyze reproducibility. Then seventeen rat models of HCC were divided into treatment group (n = 8, 30 mg/kg/day sorafenib for five days) and control group (n = 9). CEUS was performed at baseline and 14 days after first treatment, and changes of perfusion parameters were analyzed. In treatment group, CEUS perfusion parameters showed a significant change. The peak enhancement (PE, 2.50 x103±1.68 x103 vs 5.55x102±4.65x102, p = 0.010) and wash-in and wash out AUC (WiWoAUC, 1.07x105±6.48 x104 vs 2.65x104±2.25x104, p = 0.009) had significantly decreased two weeks after treatment. On the contrary, control group did not show a significant change, including PE (1.15 x103±7.53x102 vs 9.43x102± 7.81 x102, p = 0.632) and WiWoAUC (5.09 x104±3.25x104 vs 5.92 x104±3.20x104, p = 0.646). For reproducibility, the various degrees of inter-scanner reproducibility were from poor to good (ICC: &lt;0.01-0.63). However, inter-operator reproducibility of important perfusion parameters, including WiAUC, WoAUC, and WiWoAUC, ranged from fair to excellent (ICC: 0.59-0.93) in a different scanner. Therefore, CEUS was useful for assessment of the treatment response after targeted therapy and with fair to excellent inter-operator reproducibility.
DOI: 10.21258/1565622
title: Inventaire forestier national suisse - Tableau no 898326
DOI: 10.21258/1583949
title: Inventario forestale nazionale svizzero - Tabella n. 899135
DOI: 10.21258/1616202
title: Inventario forestale nazionale svizzero - Tabella n. 898999
DOI: 10.21258/1548549
title: Inventaire forestier national suisse - Tableau no 896938
DOI: 10.21258/1543119
title: Inventaire forestier national suisse - Tableau no 892997
DOI: 10.21258/1597490
title: Inventario forestale nazionale svizzero - Tabella n. 892997
DOI: 10.21227/zdw3-rf85
title: Experimental Comparison of Optical Inline 3D Measurement and Inspection Systems

description: Fast optical 3D inline inspection sensors are a powerful tool to advance factory automation. Many of these visual inspection tasks require high speeds, resolutions and repeatability. Different approaches exist. Stereo vision, photometric stereo, light sectioning and structured light are the most common principles for inline imaging in the several micrometers to sub-millimeter resolution range. Selecting the correct sensor principle can be challenging as manufacturers’ datasheets frequently use different values to describe their systems and do not stick to proposed characterizations defined by the „Initiative Fair Data Sheet" or the VDE/VDI standards. With the help of standardized parameters this paper aims to compare four different measurement principles, namely an in-house developed single sensor light field camera, a structured light pattern projection, a laser triangulation sensor and a stereo-camera system. We demonstrate simple yet meaningful experiments to determine optical resolution, temporal noise and calibration accuracy for an objective system comparison. Additionally, the reproduction of small surface structures and an overall performance on a challenging test object is evaluated. Results show that the measurement principles partly serve different application areas. The provided methods will help end users to select the correct sensor for specific applications.
DOI: 10.21258/1620447
title: Inventario forestale nazionale svizzero - Tabella n. 899112
DOI: 10.21942/uva.13372634.v1
title: TingEtAl2020_Data_Chapter 2: Impact of anxiety on learning

description: Data was gathered from two experiments for Chih-Chung's PhD thesis, Chapter 2: The Effect of Anxiety on Reinforcement Learning<br>
DOI: 10.21942/uva.13372634
title: TingEtAl2020_Data_Chapter 2: Impact of anxiety on learning

description: Data was gathered from two experiments for Chih-Chung's PhD thesis, Chapter 2: The Effect of Anxiety on Reinforcement Learning<br>
DOI: 10.21258/1580619
title: Inventario forestale nazionale svizzero - Tabella n. 902141
DOI: 10.21258/1612695
title: Inventario forestale nazionale svizzero - Tabella n. 891902
DOI: 10.5281/zenodo.4320562
title: CAsoft Example - Zener diode

description: Template file for CASoft software (Link for CASoft download), filled in with data from JCGM106:2012, Section 7.3.3 Example 1
description: The EMPIR initiative is co-funded by the European Union's Horizon 2020 research and innovation program and the EMPIR Participating States.
description: {"references": ["A.Allard et al. Risk calculations for conformity assessment in practice, 19th International Congress of Metrology (CIM2019), 2019, DOI: 10.1051/metrology/201916001"]}
DOI: 10.5281/zenodo.3895758
title: CAsoft Example - Zener diode

description: Template file for CASoft software (Link for CASoft download), filled in with data from JCGM106:2012, Section 7.3.3 Example 1
description: The EMPIR initiative is co-funded by the European Union's Horizon 2020 research and innovation program and the EMPIR Participating States.
description: {"references": ["A.Allard et al. Risk calculations for conformity assessment in practice, 19th International Congress of Metrology (CIM2019), 2019, DOI: 10.1051/metrology/201916001"]}
DOI: 10.21258/1606047
title: Inventario forestale nazionale svizzero - Tabella n. 891725
DOI: 10.21258/1577935
title: Inventario forestale nazionale svizzero - Tabella n. 898941
DOI: 10.15129/7f5ad66e-b4e0-489e-ae80-867a98e4833c
title: Voxel based modelling of stress in digital light processing datastore

description: Calibration data of stress measurements (jpeg images) taken Oct 2019 - Jan 2019. Selected MATLAB models of polymerization process Selected COMSOL models of deformation due to stress
DOI: 10.21258/1535152
title: Inventaire forestier national suisse - Tableau no 898152
DOI: 10.21258/1567800
title: Inventaire forestier national suisse - Tableau no 893445