cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24305578
title: Supplementary Material for: Spectrum of Cerebrovascular disease in Scleroderma: A Case Series and Systematic Review.

description: Introduction Central nervous system involvement in scleroderma has traditionally been considered uncommon. Recent studies suggest that scleroderma might be associated with an increased risk of cerebrovascular disease (CBVD), independent of conventional cardiovascular risk factors. We present a case series and a systematic review to capture the spectrum of CBVD in scleroderma, through a detailed description of clinical, demographic, laboratory, and radiographical findings. Methods In our case series, we included consecutive patients with scleroderma and CBVD seen over 35 years by our group in different hospitals in the United States. We also performed a systematic review from inception to July 2022. MEDLINE/EMBASE/WoS were searched for “scleroderma”, “systemic scleroderma", "systemic sclerosis", "cerebrovascular", "stroke", "cerebrovascular disorders", "cerebrovascular disease". Results Fourteen patients with scleroderma and CBVD were included in our case series (mean age 48-year, 85% female). CBVDs were ischemic stroke (64%), hemorrhagic stroke (7%), venous thrombosis (7%), ischemic optic neuropathy (7%), probable ischemic stroke (14%). Of the 110 studies identified in our systematic review (45,484 patients), 82 reports with patient level data were included for quantitative analysis (93 patients, mean age 48-year, 79% female). Despite 16 different CBVD types identified, ischemic stroke was the most common CBVD (29%), followed by vasculopathy (20%), hemorrhage (12%), vasculitis (11%), and intracranial aneurysm (11%). Discussion/Conclusion Our relatively large case series combined with a systematic review of CBVD in SCL patients shows a heterogeneous spectrum of CBVD etiology, with acute ischemic stroke being the most common in our cases and in our literature review. A complex interaction between chronic inflammation, autoimmune mechanisms, and endothelial dysfunction seems to underlie the CBVD heterogeneity in scleroderma patients. This review informs clinicians about the spectrum of CBVD related to scleroderma and raise awareness about scleroderma being a possible risk factor for early onset CBVD.
DOI: 10.5281/zenodo.8402425
title: Model output data to "Land surface modeling in the Himalayas: on the importance of evaporative fluxes for the water balance of a high elevation catchment"

description: We provide i) gridded initial conditions (.tif), ii) modeled gridded monthly outputs (.tif), and iii) modeled hourly outputs at the station locations (.txt) for the hydrological year 2019. Information about the variables and units can be found in the figures (.png) associated to each dataset. Details about the datasets can be found in the original publication by Buri and others (2023).
 
Buri, P., Fatichi, S., Shaw, T. E., Miles, E. S., McCarthy, M. J., Fyffe, C. L., ... & Pellicciotti, F. (2023). Land Surface Modeling in the Himalayas: On the Importance of Evaporative Fluxes for the Water Balance of a High‐Elevation Catchment. Water Resources Research, 59(10), e2022WR033841. DOI: 10.1029/2022WR033841
DOI: 10.5281/zenodo.8402426
title: Model output data to "Land surface modeling in the Himalayas: on the importance of evaporative fluxes for the water balance of a high elevation catchment"

description: We provide i) gridded initial conditions (.tif), ii) modeled gridded monthly outputs (.tif), and iii) modeled hourly outputs at the station locations (.txt) for the hydrological year 2019. Information about the variables and units can be found in the figures (.png) associated to each dataset. Details about the datasets can be found in the original publication by Buri and others (2023).
 
Buri, P., Fatichi, S., Shaw, T. E., Miles, E. S., McCarthy, M. J., Fyffe, C. L., ... & Pellicciotti, F. (2023). Land Surface Modeling in the Himalayas: On the Importance of Evaporative Fluxes for the Water Balance of a High‐Elevation Catchment. Water Resources Research, 59(10), e2022WR033841. DOI: 10.1029/2022WR033841
DOI: 10.5281/zenodo.10075719
title: Bevergern Apotheke

description: Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a
German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf.
gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope):
https://kalliope-verbund.info/DE-611-BF-70963
[Funktion: Im Findbuch anzeigen]
 
Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot
be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf
Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht
veröffentlicht werden dürfen).
DOI: 10.5281/zenodo.10075743
title: myiothlypis_chrysogaster_decontaminated_FSCR.fasta.gz

description: myiothlypis_chrysogaster_decontaminated_FSCR.fasta.gz
DOI: 10.5281/zenodo.10075742
title: myiothlypis_chrysogaster_decontaminated_FSCR.fasta.gz

description: myiothlypis_chrysogaster_decontaminated_FSCR.fasta.gz
DOI: 10.6084/m9.figshare.24304438
title: Supplementary Material for: Is the pentagon-copying task more than a cognitive feature? Associations with handgrip strength, gait speed and frailty in older adults

description: Background: The pentagon copy is a sensitive item to the prediction of cognitive decline and dementia. Cognitive and physical/motor decline are able to accelerate the evolution of each other, by representing a common pathway towards frailty. Objectives: To investigate the association of the pentagon-copying task with physical and motor performances and with frailty, in a sample of older adults. Method: This observational, cross-sectional and single-center study was conducted in a Geriatric Outpatients Clinic. Subjects aged ≥ 65 years were consecutively recruited, on a voluntary basis. Subjects with positive psychiatric history, with a severe neurocognitive disorder, with severe limitations on the upper limbs and/or reporting sensory deficits were excluded. The pentagon-copying task was scored from the Mini Mental State Examination; the Qualitative Scoring Pentagon Test (QSPT) was also used. Handgrip strength was measured; a 46-item Frailty Index was calculated; in subjects with autonomous walking, a 4-meter gait speed was also measured. Results: The study included 253 subjects (mean age 80.59 ± 6.89 years). Subjects making a wrong pentagon copy showed greater odds of exhibiting a strength deficit (OR = 3.57; p=0.001) and of being frail (OR= 4.80; p&lt;0.001), and exhibited a slower gait. The QSTP score was significantly correlated with handgrip strength (r= 0.388) and gait speed (r= 0.188), and inversely correlated with frailty (r= -0.428); the QSTP score was significantly different between the quartiles of handgrip strength and frailty. Conclusions: The pentagon copying-task might also be confirmed as a quick screening tool of aging trajectories towards frailty, by jointly evaluating cognitive and physical performances.
DOI: 10.5281/zenodo.8188926
title: Tooth enamel nLC-MS dataset for: Unbalanced sex-ratio in the Neolithic individuals from the Escoural Cave (Montemor-o-Novo, Portugal) revealed by peptide analysis

description: nLC-MS .raw data of tooth enamel samples from archaeological human remains. 


The dataset is related to the publication of Granja et al.
DOI: 10.5281/zenodo.8188927
title: Tooth enamel nLC-MS dataset for: Unbalanced sex-ratio in the Neolithic individuals from the Escoural Cave (Montemor-o-Novo, Portugal) revealed by peptide analysis

description: nLC-MS .raw data of tooth enamel samples from archaeological human remains. 


The dataset is related to the publication of Granja et al.
DOI: 10.5281/zenodo.10075756
title: United Atom Parameters for United Atom Multiscale Modelling Of Bio-Nano Interactions Of PEG Coated Nanoparticles

description: Short-range surface adsorption potentials of carbohydrates, lipid fragments, and amino acid side chains in tabulated form.
Recovered from radial distribution functions
Force Fields: adapted CHARMM36.
Material: PEG
Status: updated on  November 6, 2023
DOI: 10.5281/zenodo.6066502
title: United Atom Parameters for United Atom Multiscale Modelling Of Bio-Nano Interactions Of PEG Coated Nanoparticles

description: Short-range surface adsorption potentials of carbohydrates, lipid fragments, and amino acid side chains in tabulated form.
Recovered from radial distribution functions
Force Fields: adapted CHARMM36.
Material: PEG
Status: updated on  November 6, 2023
DOI: 10.5281/zenodo.6066503
title: United Atom Parameters for United Atom Multiscale Modelling Of Bio-Nano Interactions Of PEG Coated Nanoparticles

description: Short-range surface adsorption potentials of carbohydrates, lipid fragments, and amino acid side chains in tabulated form. Recovered from radial distribution functions Force Fields: adapted CHARMM36. Material: PEG
DOI: 10.6084/m9.figshare.24297796.v1
title: Supplementary Material for: Mild renal function impairment and long-term outcomes in patients with three-vessel coronary artery disease: a cohort study

description: Background: Limited data are available on the long-term impact of mild renal dysfunction (eGFR 60-89 ml/min/1.73m2) in patients with three-vessel coronary disease (3VD). Methods: A total of 5,272 patients with 3VD undergoing revascularization were included and were categorized into 3 groups: normal renal function (eGFR ≥90 ml/min/1.73m2, n=2352), mild renal dysfunction (eGFR 60-89, n=2501) and moderate renal dysfunction (eGFR 30-59, n=419). Primary endpoint was all-cause death. Secondary endpoints included cardiac death and major adverse cardiac and cerebrovascular events (MACCE), a composite of death, myocardial infarction and stroke. Results During the median 7.6-year follow-up period, 555 (10.5%) deaths occurred. After multivariable adjustment, patients with mild and moderate renal dysfunction had significantly higher risks of all-cause death (adjusted HR: 1.36, 95% CI 1.07-1.70; adjusted HR 2.06, 95% CI 1.53-2.78, respectively) compared with patients with normal renal function. patients after coronary artery bypass grafting (CABG) had a lower rate of all-cause death and MACCE than those undergoing percutaneous coronary intervention (PCI) in the normal and mild renal dysfunction group, but not in the moderate renal dysfunction group. Results were similar after propensity score matching. Conclusions In patients with 3VD, even mild renal impairment was significantly associated with a higher risk of all-cause death. The superiority of CABG over PCI diminished in those with moderate renal dysfunction. Our study alerts clinicians to the early screening of mild renal impairment in patients with 3VD and provides real-world evidence on the optimal revascularization strategy in patients with renal impairment.
DOI: 10.6084/m9.figshare.24237321
title: <i>NF1</i> alterations in cancers: therapeutic implications in precision medicine

description: <i>NF1</i> is a tumor suppressor gene encoding neurofibromin, an inhibitor of the RAS/MAPK and PI3K-AKT-mTOR signaling pathways. <i>NF1</i> germline pathogenic variants cause the tumor predisposition syndrome neurofibromatosis type 1. Targeted therapies (MEK inhibitors) have been approved for benign nerve sheath tumors in neurofibromatosis type 1 patients. <i>NF1</i> somatic alterations are present in ~5% of all human sporadic cancers. In melanomas, acute myeloid leukemias and lung adenocarcinomas, the <i>NF1</i> somatic alteration frequency is higher (~15%). However, to date, the therapeutic impact of <i>NF1</i> somatic alterations is poorly investigated. This review presents a comprehensive overview of targeted therapies and immunotherapies currently developed and evaluated <i>in vitro</i> and <i>in vivo</i> for <i>NF1</i>-altered cancer treatment. A PubMed database literature review was performed to select relevant original articles. Active clinical trials were researched in ClinicalTrials.gov database in August 2022. TCGA and HGMD® databases were consulted. This review highlights the need to better understand the molecular mechanisms of <i>NF1</i>-altered tumors and the development of innovative strategies to effectively target <i>NF1</i>-loss in human cancers. One of the current major challenges in cancer management is the targeting of tumor suppressor genes such as <i>NF1</i> gene. Currently, most studies are focusing on inhibitors of the RAS/MAPK and PI3K-AKT-mTOR pathways and immunotherapies
DOI: 10.6084/m9.figshare.24237321.v1
title: <i>NF1</i> alterations in cancers: therapeutic implications in precision medicine

description: <i>NF1</i> is a tumor suppressor gene encoding neurofibromin, an inhibitor of the RAS/MAPK and PI3K-AKT-mTOR signaling pathways. <i>NF1</i> germline pathogenic variants cause the tumor predisposition syndrome neurofibromatosis type 1. Targeted therapies (MEK inhibitors) have been approved for benign nerve sheath tumors in neurofibromatosis type 1 patients. <i>NF1</i> somatic alterations are present in ~5% of all human sporadic cancers. In melanomas, acute myeloid leukemias and lung adenocarcinomas, the <i>NF1</i> somatic alteration frequency is higher (~15%). However, to date, the therapeutic impact of <i>NF1</i> somatic alterations is poorly investigated. This review presents a comprehensive overview of targeted therapies and immunotherapies currently developed and evaluated <i>in vitro</i> and <i>in vivo</i> for <i>NF1</i>-altered cancer treatment. A PubMed database literature review was performed to select relevant original articles. Active clinical trials were researched in ClinicalTrials.gov database in August 2022. TCGA and HGMD® databases were consulted. This review highlights the need to better understand the molecular mechanisms of <i>NF1</i>-altered tumors and the development of innovative strategies to effectively target <i>NF1</i>-loss in human cancers. One of the current major challenges in cancer management is the targeting of tumor suppressor genes such as <i>NF1</i> gene. Currently, most studies are focusing on inhibitors of the RAS/MAPK and PI3K-AKT-mTOR pathways and immunotherapies
DOI: 10.6084/m9.figshare.24476752.v1
title: Supplementary Material for: Donor Lymphocyte Infusion Is a Feasible Way to Improve Survival in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Who Relapse after Allogeneic Stem Cell Transplantation

description: Introduction: Donor lymphocyte infusion (DLI) is used to induce remission in patients who relapse after allogeneic stem cell transplantation (allo-HSCT). During the last decade, the hypomethylating agent Azacitidine has been used together with DLI for a synergistic graft-versus-leukemia (GVL) effect. Here we report results of DLI/Azacitidine treatment from a retrospective single-center study. Methods: 50 AML/MDS patients treated for relapse after allo-HSCT between 2001 and 2020 with DLI at the Department of Hematology, at Rigshospitalet, Copenhagen University Hospital were included for analyses. A subgroup of patients who obtained complete remission (CR) after reinduction chemotherapy, received DLI in combination with low-dose (32 mg/m2) Azacitidine. Results: Overall survival in all patients after DLI treatment was 59% at 2 years and 20% at 5 years. Relapse-free survival in patients in CR prior to DLI was 32% after 2 years and 7% after 5 years. In the DLI+low-dose-Azacitidine group, 5-years relapse-free survival was 40%. Conclusion: DLI remains an effective treatment in post-transplant relapse leaving one fifth of patients long-term survivors. Our results support the concomitant use of low-dose Azacitidine in the future use of DLI in order to enhance the GVL effect of donor lymphocytes.
DOI: 10.6084/m9.figshare.24271081
title: Supplementary Material for: Efficacy and Safety of Mechanical Thrombectomy in Elderly and Non-Elderly Patients with Large Vessel Occlusion Stroke A Systematic Review and Meta-Analysis

description: INTRODUCTION Mechanical thrombectomy (MT) is recommended for large vessel occlusion (LVO) stroke. However, most of the studies that investigated the superiority of MT over best medical management (BMM) alone included preponderantly non-elderly patients. Thus, there is uncertainty in relation to the efficacy of MT in the elderly. We aim to compare the effect of BMM to BMM plus (MT) among elderly and non-elderly patients with (LVO). METHODS We performed a systematic search of medical databases from inception to April 2023 to identify randomized studies that reported the functional outcome at 90 days by age for patients with LVO treated with MT vs. BMM. Patients were divided into elderly (&gt;70 or &gt;80 years, depending on the cut-off used in each study) and non-elderly. Outcomes were defined as excellent (modified Rankin Scale [mRS]≤1), good (mRS≤3), poor (mRS≥5), or death. Effect sizes were calculated by using random effects meta-analyses. Results were represented by odds ratio (OR) and their 95% confidence intervals (95% CI). RESULTS A total of 2,195 patients were included in the analysis (≥70 years, 7 trials, n= 696; ≥80 years, 2 trials, n=139). Non-elderly patients treated with MT had higher odds of excellent outcome (OR 3.05; 95% CI 2.23-4.18) and good outcome (OR 2.70; 95% CI 1.94-3.74), and lower odds of poor outcome (OR 0.54; 95% CI 0.40-0.72) and death (OR 0.63; 95% CI 0.41-0.96). Similarly, elderly patients treated with MT had higher odds of excellent (OR 2.39; 95% CI 1.05-5.45) and good outcomes (OR 2.18; 95% CI 1.43-3.33) and lower odds of poor outcome (OR 0.48; 95% CI 0.33-0.70) and mortality (OR 0.50; 0.26-0.95). When outcomes were analyzed by age subgroups, MT was associated with higher odds of good outcome in patients ≥70 years (OR 1.95, 95% CI 1.26-3.03) and ≥80 years (OR 4.43, 95% CI 1.02-19.23). DISCUSSION/CONCLUSION MT increases the likelihood of achieving a good outcome in elderly and non-elderly patients without increasing the risk of severe disability or death. MT, when otherwise clinically indicated, should be considered over BMM alone in both age groups.
DOI: 10.6084/m9.figshare.24271081.v1
title: Supplementary Material for: Efficacy and Safety of Mechanical Thrombectomy in Elderly and Non-Elderly Patients with Large Vessel Occlusion Stroke A Systematic Review and Meta-Analysis

description: INTRODUCTION Mechanical thrombectomy (MT) is recommended for large vessel occlusion (LVO) stroke. However, most of the studies that investigated the superiority of MT over best medical management (BMM) alone included preponderantly non-elderly patients. Thus, there is uncertainty in relation to the efficacy of MT in the elderly. We aim to compare the effect of BMM to BMM plus (MT) among elderly and non-elderly patients with (LVO). METHODS We performed a systematic search of medical databases from inception to April 2023 to identify randomized studies that reported the functional outcome at 90 days by age for patients with LVO treated with MT vs. BMM. Patients were divided into elderly (&gt;70 or &gt;80 years, depending on the cut-off used in each study) and non-elderly. Outcomes were defined as excellent (modified Rankin Scale [mRS]≤1), good (mRS≤3), poor (mRS≥5), or death. Effect sizes were calculated by using random effects meta-analyses. Results were represented by odds ratio (OR) and their 95% confidence intervals (95% CI). RESULTS A total of 2,195 patients were included in the analysis (≥70 years, 7 trials, n= 696; ≥80 years, 2 trials, n=139). Non-elderly patients treated with MT had higher odds of excellent outcome (OR 3.05; 95% CI 2.23-4.18) and good outcome (OR 2.70; 95% CI 1.94-3.74), and lower odds of poor outcome (OR 0.54; 95% CI 0.40-0.72) and death (OR 0.63; 95% CI 0.41-0.96). Similarly, elderly patients treated with MT had higher odds of excellent (OR 2.39; 95% CI 1.05-5.45) and good outcomes (OR 2.18; 95% CI 1.43-3.33) and lower odds of poor outcome (OR 0.48; 95% CI 0.33-0.70) and mortality (OR 0.50; 0.26-0.95). When outcomes were analyzed by age subgroups, MT was associated with higher odds of good outcome in patients ≥70 years (OR 1.95, 95% CI 1.26-3.03) and ≥80 years (OR 4.43, 95% CI 1.02-19.23). DISCUSSION/CONCLUSION MT increases the likelihood of achieving a good outcome in elderly and non-elderly patients without increasing the risk of severe disability or death. MT, when otherwise clinically indicated, should be considered over BMM alone in both age groups.
DOI: 10.17632/tns8c38r6d.1
title: Body Measurements (Anthropometry)

description: Anthropometry is the study of measuring the human body in terms of bone dimensions, muscle mass, and adipose tissue. This database contains the measurements of 9 university students, with a total of 29 anthropometric attributes recorded. This work is the first in a series aimed at ultimately developing an ergonomic-compliant instructional workstation.
DOI: 10.17632/tns8c38r6d.2
title: Body Measurements (Anthropometry)

description: Anthropometry is the study of measuring the human body in terms of bone dimensions, muscle mass, and adipose tissue. This database contains the measurements of 9 university students, with a total of 29 anthropometric attributes recorded. This work is the first in a series aimed at ultimately developing an ergonomic-compliant instructional workstation.
DOI: 10.17632/8cnyr49kyh.1
title: Supplemental Material. Melanoma Incidence and Mortality: Exploring the Impact of Regional UV Radiation and Socioeconomic Status in the Context of Breslow Thickness

description: Supplemental Material. Melanoma Incidence and Mortality: Exploring the Impact of Regional UV Radiation and Socioeconomic Status in the Context of Breslow Thickness
DOI: 10.17632/5tzpxx5w8x.1
title: Data for BEV usage in the EU (member states energy mix)

description: Based on EU-27 energy mix (2011-2021) the calculation of the Energy-Specific CO2 Emission Parameter [gCO2/MJmotion] and total efficiency of energy conversions, transmission, and battery are summarized. It was used for Well-to-Wheel evaluation and comparison of the member states.