cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7165483.v1
title: Supplementary Material for: Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index

description: <b><i>Background:</i></b> Fric test is a useful tool for the diagnosis and threshold testing for symptomatic dermographism. When threshold testing is not available, Urticaria Control Test (UCT) and Dermatology Life Quality Index (DLQI) might be used to assess disease control and quality of life (QoL) impairment, respectively. <b><i>Objectives:</i></b> In this study, we aimed to describe a new scoring system for the Fric test and evaluate the correlations of Fric scores with UCT, DLQI, and other disease activity assessment scores. <b><i>Method:</i></b> Provocation test with Fric Test 4.0 was performed in all patients at referral and at the 4th week. We considered a 4-grade rating score for Fric Test (0–4) [Total Fric Score (TFS)]. A positive response with all of the four pins suggested severe dermographism (TFS = 4), while a wheal with only the largest pin (4.5 mm) was considered as milder disease (TFS = 1). Treatment responses were evaluated with Fric Test 4.0, UCT, patient’s global assessment of disease severity (PatGA-VAS), the physician’s global assessment of disease control (PhyGA-VAS), and DLQI at baseline and at the 4th week of treatment. The correlations of TFS with UCT, DLQI, PatGA-VAS, PhyGA-VAS at baseline as well as the changes in the mean scores after treatment (week 4) were performed. <b><i>Results:</i></b> The mean UCT and DLQI scores were 8.69 ± 3.40 and 7.88 ± 6.02 at the first visit. At the second visit, TFS decreased from a mean of 2.79 ± 1.68 to 1.91 ± 1.85 (<i>p</i> &lt; 0.001), and UCT scores and PhyGA-VAS were increased (<i>p</i> &lt; 0.001), while DLQI scores, PatGA-VAS, and pruritus scores decreased significantly (<i>p</i> = 0.002; <i>p</i> = 0.001; <i>p</i> = 0.012). There was a positive correlation between TFS and pruritus scores (<i>r</i> = 0.378) and DLQI scores (<i>r</i> = 0.392). TFS was found to have a negative correlation with UCT score (<i>r</i> = –0.283) and PhyGA-VAS (<i>r</i> = –0.347). <b><i>Conclusions:</i></b> This new Fric scoring system allows comparison with other tools and shows moderate correlations with most of the tools. Using disease-specific tools is recommended since they provide a subjective evaluation of disease severity, QoL impairment, and disease control.
DOI: 10.6084/m9.figshare.7165481
title: Multi-region community occupancy analysis dataset

description: Camera trap data for mammal communities, collected in five regions in the forests of the Udzungwa Mountains,Tanzania. Standardized species traits and habitat parameters are available too. Data are formatted in three-dimensional matrices to be used in a multi-region, community occupancy analysis.
DOI: 10.6084/m9.figshare.7165481.v1
title: Multi-region community occupancy analysis dataset

description: Camera trap data for mammal communities, collected in five regions in the forests of the Udzungwa Mountains,Tanzania. Standardized species traits and habitat parameters are available too. Data are formatted in three-dimensional matrices to be used in a multi-region, community occupancy analysis.
DOI: 10.7284/115454
title: Gyrocompass data collected during research cruise WS0718 using a SGB Meridian instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7165479
title: Supplementary Material for: Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution

description: <b><i>Background:</i></b> Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory. <b><i>Objective:</i></b> The aim of this study was to determine the effect of hypofractionated radiotherapy. <b><i>Methods:</i></b> Thirty-three patients who received radiotherapy for ATC between January 2000 and December 2014 were retrospectively included. We defined hypofractionated radiotherapy as a single dose ≥5 Gy. <b><i>Results:</i></b> Nineteen patients were treated with hypofractionated radiotherapy. Twenty-eight patients died, and 27 of those patients died from ATC. Sixteen patients died from distant metastasis and 6 from local recurrence. In the hypofractionated radiotherapy group, local recurrence occurred in 5 patients and 1 of them died from active bleeding from a local tumor. There was local recurrence in 7 patients who received the other protocol, and 5 of them died from asphyxiation, active bleeding, or uncontrollable growth of a local tumor on the neck. The median overall survival (OS) was 5 months. In multivariate analysis, patients who received an equivalent dose in 2-Gy fractions (EQD<sub>2</sub>) ≥50 Gy had significantly better OS (<i>p</i> = 0.016). In univariate analysis, patients who received hypofractionated radiotherapy did not have significantly better OS (<i>p</i> = 0.872) or local control (<i>p</i> = 0.090). The χ<sup>2</sup> test showed that significantly fewer patients died from local recurrence in the hypofractionated radiotherapy group (<i>p</i> = 0.025). <b><i>Conclusions:</i></b> Multivariate analysis showed that an EQD<sub>2</sub> ≥50 Gy resulted in better OS, and hypofractionated radiotherapy decreased the rate of mortality from local recurrence.
DOI: 10.6084/m9.figshare.7165479.v1
title: Supplementary Material for: Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution

description: <b><i>Background:</i></b> Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory. <b><i>Objective:</i></b> The aim of this study was to determine the effect of hypofractionated radiotherapy. <b><i>Methods:</i></b> Thirty-three patients who received radiotherapy for ATC between January 2000 and December 2014 were retrospectively included. We defined hypofractionated radiotherapy as a single dose ≥5 Gy. <b><i>Results:</i></b> Nineteen patients were treated with hypofractionated radiotherapy. Twenty-eight patients died, and 27 of those patients died from ATC. Sixteen patients died from distant metastasis and 6 from local recurrence. In the hypofractionated radiotherapy group, local recurrence occurred in 5 patients and 1 of them died from active bleeding from a local tumor. There was local recurrence in 7 patients who received the other protocol, and 5 of them died from asphyxiation, active bleeding, or uncontrollable growth of a local tumor on the neck. The median overall survival (OS) was 5 months. In multivariate analysis, patients who received an equivalent dose in 2-Gy fractions (EQD<sub>2</sub>) ≥50 Gy had significantly better OS (<i>p</i> = 0.016). In univariate analysis, patients who received hypofractionated radiotherapy did not have significantly better OS (<i>p</i> = 0.872) or local control (<i>p</i> = 0.090). The χ<sup>2</sup> test showed that significantly fewer patients died from local recurrence in the hypofractionated radiotherapy group (<i>p</i> = 0.025). <b><i>Conclusions:</i></b> Multivariate analysis showed that an EQD<sub>2</sub> ≥50 Gy resulted in better OS, and hypofractionated radiotherapy decreased the rate of mortality from local recurrence.
DOI: 10.7284/115455
title: Radiometer data collected during research cruise WS0718 using a Eppley PSP instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/115456
title: Radiometer data collected during research cruise WS0718 using a Eppley TUV instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/115459
title: Radiometer data collected during research cruise WS0718 using a Eppley PIR instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7165459
title: Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors

description: There is an increasing interest in developing novel eosinophil peroxidase (EPO) inhibitors, in order to provide new treatment strategies against chronic inflammatory and neurodegenerative diseases caused by eosinophilic disorder. Within this study, a ligand-based pharmacophore model for EPO inhibitors was generated and used for <i>in silico</i> screening of large 3 D molecular structure databases, containing more than 4 million compounds. Hits obtained were clustered and a total of 277 compounds were selected for biological assessment. A class of 2-(phenyl)amino-aceto-hydrazides with different substitution pattern on the aromatic ring was found to contain the most potent EPO inhibitors, exhibiting IC<sub>50</sub> values down to 10 nM. The generated pharmacophore model therefore, represents a valuable tool for the selection of compounds for biological testing. The compounds identified as potent EPO inhibitors will serve to initiate a hit to lead and lead optimisation program for the development of new therapeutics against eosinophilic disorders.
DOI: 10.6084/m9.figshare.7165453
title: Supplementary Material for: Bronchoscopic Lung Volume Reduction Treatment Using Endobronchial Valves for Emphysema: Emerging Questions

description: Medicine
DOI: 10.6084/m9.figshare.7165459.v1
title: Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors

description: There is an increasing interest in developing novel eosinophil peroxidase (EPO) inhibitors, in order to provide new treatment strategies against chronic inflammatory and neurodegenerative diseases caused by eosinophilic disorder. Within this study, a ligand-based pharmacophore model for EPO inhibitors was generated and used for <i>in silico</i> screening of large 3 D molecular structure databases, containing more than 4 million compounds. Hits obtained were clustered and a total of 277 compounds were selected for biological assessment. A class of 2-(phenyl)amino-aceto-hydrazides with different substitution pattern on the aromatic ring was found to contain the most potent EPO inhibitors, exhibiting IC<sub>50</sub> values down to 10 nM. The generated pharmacophore model therefore, represents a valuable tool for the selection of compounds for biological testing. The compounds identified as potent EPO inhibitors will serve to initiate a hit to lead and lead optimisation program for the development of new therapeutics against eosinophilic disorders.
DOI: 10.6084/m9.figshare.7165453.v1
title: Supplementary Material for: Bronchoscopic Lung Volume Reduction Treatment Using Endobronchial Valves for Emphysema: Emerging Questions

description: Medicine
DOI: 10.7284/115458
title: Rain Gauge data collected during research cruise WS0718 using a OSI ORG-815 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/115457
title: Water Temperature data collected during research cruise WS0718 using a Sea-Bird SBE-38 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/115461
title: Winch data collected during research cruise WS0718 using a General Oceanics DT1020 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/111668
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise WS0802 using a Sea-Bird SBE-911plus instrument system onboard the platform RV F.G. Walton Smith
DOI: 10.7284/115472
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise WS0807 using a Sea-Bird SBE-911plus instrument system onboard the platform RV F.G. Walton Smith
DOI: 10.7284/115464
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS0807 using a Raytheon 300 WAAS instrument system onboard the platform RV F.G. Walton Smith
DOI: 10.7284/115465
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS0807 using a Raytheon 320 WAAS instrument system onboard the platform RV F.G. Walton Smith
DOI: 10.6084/m9.figshare.7717826
title: Infection control measures in neonatal units: implementation of change in the Gaza-Strip

description: <b>Introduction:</b> Low-income countries rarely report infection control measures although they are key to reducing mortality and morbidity in healthcare. This audit examined healthcare personnel’s adherence to infection control measures before entry to the NICU and in both minor and major procedures’ bundles. Furthermore, it examined the effect of subsequent authorization and dissemination of infection control guidelines followed by education and training sessions on the adherence of healthcare personnel to infection control policies. <b>Methods:</b> This prospective observational study was conducted in two NICUs at two separate hospitals in the Gaza-Strip, Palestine. The initial observation period was June–August 2016 during which healthcare professionals’ adherence to infection control policies was assessed by direct observation. This was followed by NICU feedback dissemination and on-site educational and training sessions. Then, the reaudit, following the same protocol, was carried out throughout February 2017. <b>Results:</b> There was a statistically significant improvement in the adherence to infection control measures among healthcare personnel. Significant improvements were found in both minor and major procedure infection control protocols’ adherence rates. However, when comparing the general neonatal handling adherence rate between both audits, no significant change was noted. <b>Discussion:</b> This study highlights the effectiveness of using audit feedback and on-site educational and training sessions in the enhancement of adherence to infection control policies, demonstrating significant improvement in areas covered by the staff training program. Therefore, including regular infection control training combined with feedback in the curriculum of healthcare professionals can improve the sustainability of infection control programs. Further studies must examine the impact of such training also on the incidence of healthcare-associated infection rates as well as morbidity and mortality within neonatal units.
DOI: 10.6084/m9.figshare.7717826.v1
title: Infection control measures in neonatal units: implementation of change in the Gaza-Strip

description: <b>Introduction:</b> Low-income countries rarely report infection control measures although they are key to reducing mortality and morbidity in healthcare. This audit examined healthcare personnel’s adherence to infection control measures before entry to the NICU and in both minor and major procedures’ bundles. Furthermore, it examined the effect of subsequent authorization and dissemination of infection control guidelines followed by education and training sessions on the adherence of healthcare personnel to infection control policies. <b>Methods:</b> This prospective observational study was conducted in two NICUs at two separate hospitals in the Gaza-Strip, Palestine. The initial observation period was June–August 2016 during which healthcare professionals’ adherence to infection control policies was assessed by direct observation. This was followed by NICU feedback dissemination and on-site educational and training sessions. Then, the reaudit, following the same protocol, was carried out throughout February 2017. <b>Results:</b> There was a statistically significant improvement in the adherence to infection control measures among healthcare personnel. Significant improvements were found in both minor and major procedure infection control protocols’ adherence rates. However, when comparing the general neonatal handling adherence rate between both audits, no significant change was noted. <b>Discussion:</b> This study highlights the effectiveness of using audit feedback and on-site educational and training sessions in the enhancement of adherence to infection control policies, demonstrating significant improvement in areas covered by the staff training program. Therefore, including regular infection control training combined with feedback in the curriculum of healthcare professionals can improve the sustainability of infection control programs. Further studies must examine the impact of such training also on the incidence of healthcare-associated infection rates as well as morbidity and mortality within neonatal units.
DOI: 10.6084/m9.figshare.7856768
title: Medical indications for primary cesarean delivery in women with and without disabilities

description: <b>Background:</b> Prior research has found that women with disabilities are more likely to deliver by cesarean than are women without disabilities. It is not clear whether all of the cesarean deliveries among women with disabilities are medically necessary. <b>Objectives:</b> To examine the associations between maternal disability status and type, mode of delivery, and medical indications for cesarean delivery in California deliveries. <b>Study design:</b> Retrospective cohort study of all nulliparous births in California between 2000 and 2012. We classified births as to whether or not women underwent a trial of labor and determined if medical indications for cesarean delivery were present. Multivariable logistic regression models examined the association of disability with trial of labor and indications for cesarean delivery. <b>Results:</b> Women with disabilities had lower odds of having a labored delivery, compared to women without disabilities (adjusted odds ratio (aOR) = 0.45, 95% confidence interval (CI) 0.41–0.49). In the sample of women who labored (90.5% of total), women with disabilities were more likely to have a medical indication for cesarean delivery (aOR = 1.15, 95% CI 1.10–1.21) and were more likely to have a cesarean delivery (aOR = 1.46, 95% CI = 1.38–1.54). In the subsample of unlabored cesarean deliveries, women with disabilities were less likely to have documented medical indications for cesarean delivery (aOR = 0.45, 95% CI = 0.41–0.50). <b>Conclusions:</b> Women with disabilities were less likely to labor, and these unlabored cesarean deliveries were less likely to have a medical indication for cesarean, compared to women without disabilities.
DOI: 10.6084/m9.figshare.7856768.v1
title: Medical indications for primary cesarean delivery in women with and without disabilities

description: <b>Background:</b> Prior research has found that women with disabilities are more likely to deliver by cesarean than are women without disabilities. It is not clear whether all of the cesarean deliveries among women with disabilities are medically necessary. <b>Objectives:</b> To examine the associations between maternal disability status and type, mode of delivery, and medical indications for cesarean delivery in California deliveries. <b>Study design:</b> Retrospective cohort study of all nulliparous births in California between 2000 and 2012. We classified births as to whether or not women underwent a trial of labor and determined if medical indications for cesarean delivery were present. Multivariable logistic regression models examined the association of disability with trial of labor and indications for cesarean delivery. <b>Results:</b> Women with disabilities had lower odds of having a labored delivery, compared to women without disabilities (adjusted odds ratio (aOR) = 0.45, 95% confidence interval (CI) 0.41–0.49). In the sample of women who labored (90.5% of total), women with disabilities were more likely to have a medical indication for cesarean delivery (aOR = 1.15, 95% CI 1.10–1.21) and were more likely to have a cesarean delivery (aOR = 1.46, 95% CI = 1.38–1.54). In the subsample of unlabored cesarean deliveries, women with disabilities were less likely to have documented medical indications for cesarean delivery (aOR = 0.45, 95% CI = 0.41–0.50). <b>Conclusions:</b> Women with disabilities were less likely to labor, and these unlabored cesarean deliveries were less likely to have a medical indication for cesarean, compared to women without disabilities.
DOI: 10.7284/115473
title: Winch data collected during research cruise WS0807 using a General Oceanics DT1020 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7165408
title: Lost in transition: The detrimental effect of interpersonal trauma in Syrian children in transit in Italy

description: Study on Syrian migrant children in transit to Milan on risk and protection in children MH outcomes.
DOI: 10.6084/m9.figshare.7165408.v1
title: Lost in transition: The detrimental effect of interpersonal trauma in Syrian children in transit in Italy

description: Study on Syrian migrant children in transit to Milan on risk and protection in children MH outcomes.
DOI: 10.7284/115476
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS0814 using a Raytheon 300 WAAS instrument system onboard the platform RV F.G. Walton Smith
DOI: 10.7284/115477
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS0814 using a Raytheon 320 WAAS instrument system onboard the platform RV F.G. Walton Smith
DOI: 10.7284/115481
title: Winch data collected during research cruise WS0814 using a General Oceanics DT1020 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/103815
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise WS0901 using a RDI BB-600 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/103816
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise WS0901 using a RDI OS-75 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/103814
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise WS0901 using a Sea-Bird SBE-911+ instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/103817
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS0901 using a Raytheon 300 WAAS instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition