cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4519676
title: Supplementary Material for: Neurodevelopmental Effects of Undernutrition and Placental Underperfusion in Fetal Growth Restriction Rabbit Models

description: <b><i>Introduction:</i></b> Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental effects of both situations in pregnant rabbits was performed. <b><i>Materials and Methods:</i></b> The placental underperfusion model was induced after uteroplacental vessel ligation at 25 days of pregnancy. The undernutrition model was induced after a reduction of 70% of the basal maternal intake at 22 days of pregnancy. Neurobehavioral tests were applied in the derived offspring at the neonatal period and over the long term. Structural brain differences were evaluated by brain networks obtained from diffusion magnetic resonance imaging. <b><i>Results:</i></b> Birth weight was significantly lower in both cases. However, stillbirth was only increased in the placental underperfusion model. Cases from both models presented poorer neurobehavioral performance and network infrastructure, being more pronounced in the placental underperfusion model. <b><i>Discussion:</i></b> Prenatal insults during the last third of gestation resulted in functional and structural disturbances. The degree of neurodevelopmental impairment and its association with structural brain reorganization seemed to be related to the type of the prenatal insult, showing stronger effects in the placental underperfusion model.
DOI: 10.6084/m9.figshare.4519679
title: Supplementary Material for: Androgen Receptor Gene Copy Number and Protein Expression in Treatment-Naïve Prostate Cancer

description: <b><i>Objectives:</i></b> To evaluate the androgen receptor (AR) gene copy number in androgen deprivation therapy (ADT) treatment-naïve prostate cancer (PCa) patients and to evaluate the corresponding AR protein expression and assess the association between these features and prognostic factors. <b><i>Materials and Methods:</i></b> Chromosome X and AR gene copy number, using fluorescence-in-situ-hybridization, and epithelial-stromal AR expression, using AR immunohistochemistry, were analyzed in 62 ADT treatment-naïve PCa patients and 8 castration-refractory patients. <b><i>Results:</i></b> In ADT treatment-naïve PCa patients, the AR expression was higher in tumor epithelial cells versus surrounding stromal cells (<i>p</i> &lt; 0.001) and versus normal epithelium in the same patient (<i>p</i> = 0.043). The difference between tumoral AR expression and expression in normal epithelium was higher in patients with ≥15% of tumor cells with increased AR copy number (<i>p</i> = 0.019). Peritumoral stroma had lower AR expression in patients with lymph-node or distant metastases compared to those without metastases (<i>p</i> = 0.038). <b><i>Conclusions:</i></b> This research evaluates the link between AR gene status, expression profile, and possible prognostic factors. Furthermore, it highlights the importance of the peritumoral environment in PCa. Additional research is needed to further clarify the role of stromal AR in PCa dissemination and identify possible therapeutic strategies to target this mechanism.
DOI: 10.6084/m9.figshare.4519673
title: Supplementary Material for: Development of a Normative Database for Multifocal Electroretinography in the Context of a Multicenter Clinical Trial

description: <b><i>Purpose:</i></b> The aim of this study is to present the largest normative database using multifocal electroretinography (mfERG) in the context of a multicenter clinical trial. <b><i>Methods:</i></b> This investigational study included 156 eyes from 78 Caucasian subjects aged 45-70 years without known ophthalmic disease or diabetes mellitus; the subjects were recruited from 11 clinical sites in the setting of the EUROCONDOR project. Standardized mfERG acquisition (103 hexagons per eye) was established based on the International Society of Clinical Electrophysiology in Vision. At least one technician per site received both specialized training and certification. The main variables that could have influenced the results were considered in the analyses. <b><i>Results:</i></b> The normative database was based on 111 eyes. The overall mean P1-implicit time (IT) was 33.94 ± 1.70 ms, and the mean P1 amplitude was 30.58 ± 5.20 nV/deg<sup>2</sup>. Age and gender were independently related to predictors of P1-IT but not of P1 amplitude. The responses that were averaged for the 6 rings showed a longer P1-IT time in the fovea, decreasing progressively to the parafovea and perifovea. By contrast, P1 amplitude values sharply decreased with retinal eccentricity. <b><i>Conclusions:</i></b> This normative database can be used as a comparative index of expected normal values in the clinical setting and for examining the effect of studies testing neuroprotective agents.
DOI: 10.6084/m9.figshare.4519655
title: Supplementary Material for: Establishment and Characterization of an SV40 Large T Antigen-Transduced Porcine Colonic Epithelial Cell Line

description: Continuous cell lines have become indispensable tools that have enabled investigations into cellular mechanisms by increasing experimental reproducibility and sample availability, and decreasing the use of experimental animals. To facilitate studies of epithelial barrier function of the porcine colon, we aimed to establish an epithelial cell line with an extended replicative capacity. Cells were isolated from the proximal colon of a 3-week-old piglet and transduced using a recombinant retroviral vector construct containing the simian virus 40 large T antigen (SV40 TAg). We established a clonal epithelial cell line, referred to as PoCo83-3, that stably expressed the SV40 TAg, verified at mRNA and protein levels. PoCo83-3 showed epithelial cell-specific features, such as cobblestone-like morphology, dome structure formation, the presence of apical microvilli, and the expression of keratin 18, E-cadherin and the tight junction-associated proteins zonula occludens-1, occludin, and claudin-1. To validate PoCo83-3 as an in vitro model in epithelial barrier research, proinflammatory cytokine-inducible alterations in barrier integrity were demonstrated by incubating the cells with TNF-α and IFN-γ for 48 h. These cytokine treatments promoted a decreased transepithelial electrical resistance. In summary, PoCo83-3 exhibited an extended life span and a differentiated phenotype while maintaining epithelial characteristics. Based on these results, we present this cell line as a valuable in vitro model for investigations of epithelial barrier function in the porcine colon.
DOI: 10.6084/m9.figshare.4519658
title: Supplementary Material for: C-Arm Cone Beam Computed Tomography Guidance for Radiofrequency Ablation in Hepatocellular Carcinoma

description: <b><i>Objective:</i></b> To assess the usefulness of C-arm cone beam computed tomography (CBCT) combined with ultrasound for the treatment of hepatocellular carcinoma (HCC) by radiofrequency ablation (RFA). <b><i>Methods:</i></b> Patients underwent RFA following transcatheter arterial chemoembolization (TACE) or RFA alone under ultrasound or CBCT guidance combined with ultrasound-based techniques. They were divided into 2 groups based on the use (C group) and nonuse (NC group) of CBCT guidance. The technical success of RFA and local tumor progression after the first RFA session were evaluated by dynamic contrast-enhanced imaging methods. Between-group differences were assessed retrospectively. <b><i>Results:</i></b> We enrolled 198 patients with 260 HCC nodules. The complete ablation rates were 63.0 and 89.4% in the NC and C groups, respectively. In log-rank testing, local tumor progression occurred significantly more often in the NC group when RFA was used without TACE, in males when des-gamma-carboxy prothrombin was ≥29 mAU/mL, and when the diameter of a nodule was ≥18 mm. On Cox proportional-hazards regression analysis, the NC group, RFA alone without TACE, and male gender were significant independent variables. <b><i>Conclusion:</i></b> TACE followed by RFA under CBCT and ultrasound guidance improves the reliability of ablation of target HCC nodules, reduces the need for additional treatment sessions, and prevents local tumor progression.
DOI: 10.6084/m9.figshare.4519673.v1
title: Supplementary Material for: Development of a Normative Database for Multifocal Electroretinography in the Context of a Multicenter Clinical Trial

description: <b><i>Purpose:</i></b> The aim of this study is to present the largest normative database using multifocal electroretinography (mfERG) in the context of a multicenter clinical trial. <b><i>Methods:</i></b> This investigational study included 156 eyes from 78 Caucasian subjects aged 45-70 years without known ophthalmic disease or diabetes mellitus; the subjects were recruited from 11 clinical sites in the setting of the EUROCONDOR project. Standardized mfERG acquisition (103 hexagons per eye) was established based on the International Society of Clinical Electrophysiology in Vision. At least one technician per site received both specialized training and certification. The main variables that could have influenced the results were considered in the analyses. <b><i>Results:</i></b> The normative database was based on 111 eyes. The overall mean P1-implicit time (IT) was 33.94 ± 1.70 ms, and the mean P1 amplitude was 30.58 ± 5.20 nV/deg<sup>2</sup>. Age and gender were independently related to predictors of P1-IT but not of P1 amplitude. The responses that were averaged for the 6 rings showed a longer P1-IT time in the fovea, decreasing progressively to the parafovea and perifovea. By contrast, P1 amplitude values sharply decreased with retinal eccentricity. <b><i>Conclusions:</i></b> This normative database can be used as a comparative index of expected normal values in the clinical setting and for examining the effect of studies testing neuroprotective agents.
DOI: 10.6084/m9.figshare.4519649
title: Effects of Self-Control Training Data

description: Data from a study examining the reliability of self-control training effects. Participants were randomly assigned to either a training or control group and measures were taken. Participants then engaged in training or control condition-specific instructions for a period of two weeks, and received compliance reminders and provided compliance self-reports. After two weeks, measures were re-taken. Participants were told to stop engaging in the condition specific instruction, and then returned two weeks later for a final, third measure.<br>
DOI: 10.6084/m9.figshare.4519658.v1
title: Supplementary Material for: C-Arm Cone Beam Computed Tomography Guidance for Radiofrequency Ablation in Hepatocellular Carcinoma

description: <b><i>Objective:</i></b> To assess the usefulness of C-arm cone beam computed tomography (CBCT) combined with ultrasound for the treatment of hepatocellular carcinoma (HCC) by radiofrequency ablation (RFA). <b><i>Methods:</i></b> Patients underwent RFA following transcatheter arterial chemoembolization (TACE) or RFA alone under ultrasound or CBCT guidance combined with ultrasound-based techniques. They were divided into 2 groups based on the use (C group) and nonuse (NC group) of CBCT guidance. The technical success of RFA and local tumor progression after the first RFA session were evaluated by dynamic contrast-enhanced imaging methods. Between-group differences were assessed retrospectively. <b><i>Results:</i></b> We enrolled 198 patients with 260 HCC nodules. The complete ablation rates were 63.0 and 89.4% in the NC and C groups, respectively. In log-rank testing, local tumor progression occurred significantly more often in the NC group when RFA was used without TACE, in males when des-gamma-carboxy prothrombin was ≥29 mAU/mL, and when the diameter of a nodule was ≥18 mm. On Cox proportional-hazards regression analysis, the NC group, RFA alone without TACE, and male gender were significant independent variables. <b><i>Conclusion:</i></b> TACE followed by RFA under CBCT and ultrasound guidance improves the reliability of ablation of target HCC nodules, reduces the need for additional treatment sessions, and prevents local tumor progression.
DOI: 10.6084/m9.figshare.4519646
title: Supplementary Material for: Survey of Clinical Practice Patterns in the Management of 992 Hyperthyroid Patients in France

description: <b><i>Background:</i></b> Considerable variations in diagnosis and therapeutic practices are reported for hyperthyroidism (HT) between countries. <b><i>Methods:</i></b> A clinical study was conducted among a representative sample of 263 endocrinologists in France. All consecutive patients seen for HT during the study period were included. Diagnosis and treatment modalities were recorded from hyperthyroid patients with Graves disease (GD, <i>n</i> = 802), multinodular goiter (MNG, <i>n</i> = 121), and toxic adenoma (TA, <i>n</i> = 69). <b><i>Results:</i></b> Antithyroid antibodies were measured in half of the population (anti-TPO in 48.5% and anti-TSH receptor in 57.8%). Patients had thyroid ultrasonography and scintigraphy in 93.8 and 40.3%, respectively. Therapeutic management depended on the etiology: for the first episode of GD, antithyroid drugs (ATDs) were the first-line treatment in 91% of the patients, combined with surgery in 6.1% and with radioiodine in 2.9%. Surgery was preferred to radioiodine in MNG (52.6 vs. 22.4%) and TA (59.1 vs. 24.2%). Euthyroid status was achieved after 3 months in 64.4% of GD. A “block and replace” protocol was used in 41.2% of patients. After 3 months, 73% of patients were euthyroid in the “block and replace” group compared to 56.2% in the group with ATDs alone (<i>p</i> = 0.009). For MNG and TA, more than 75% of patients were euthyroid at the 3-month follow-up. <b><i>Conclusions:</i></b> Large discrepancies remain between clinical practice and international guidelines. These results should boost efforts to improve adherence to these guidelines.
DOI: 10.6084/m9.figshare.4519646.v1
title: Supplementary Material for: Survey of Clinical Practice Patterns in the Management of 992 Hyperthyroid Patients in France

description: <b><i>Background:</i></b> Considerable variations in diagnosis and therapeutic practices are reported for hyperthyroidism (HT) between countries. <b><i>Methods:</i></b> A clinical study was conducted among a representative sample of 263 endocrinologists in France. All consecutive patients seen for HT during the study period were included. Diagnosis and treatment modalities were recorded from hyperthyroid patients with Graves disease (GD, <i>n</i> = 802), multinodular goiter (MNG, <i>n</i> = 121), and toxic adenoma (TA, <i>n</i> = 69). <b><i>Results:</i></b> Antithyroid antibodies were measured in half of the population (anti-TPO in 48.5% and anti-TSH receptor in 57.8%). Patients had thyroid ultrasonography and scintigraphy in 93.8 and 40.3%, respectively. Therapeutic management depended on the etiology: for the first episode of GD, antithyroid drugs (ATDs) were the first-line treatment in 91% of the patients, combined with surgery in 6.1% and with radioiodine in 2.9%. Surgery was preferred to radioiodine in MNG (52.6 vs. 22.4%) and TA (59.1 vs. 24.2%). Euthyroid status was achieved after 3 months in 64.4% of GD. A “block and replace” protocol was used in 41.2% of patients. After 3 months, 73% of patients were euthyroid in the “block and replace” group compared to 56.2% in the group with ATDs alone (<i>p</i> = 0.009). For MNG and TA, more than 75% of patients were euthyroid at the 3-month follow-up. <b><i>Conclusions:</i></b> Large discrepancies remain between clinical practice and international guidelines. These results should boost efforts to improve adherence to these guidelines.
DOI: 10.6084/m9.figshare.4519655.v1
title: Supplementary Material for: Establishment and Characterization of an SV40 Large T Antigen-Transduced Porcine Colonic Epithelial Cell Line

description: Continuous cell lines have become indispensable tools that have enabled investigations into cellular mechanisms by increasing experimental reproducibility and sample availability, and decreasing the use of experimental animals. To facilitate studies of epithelial barrier function of the porcine colon, we aimed to establish an epithelial cell line with an extended replicative capacity. Cells were isolated from the proximal colon of a 3-week-old piglet and transduced using a recombinant retroviral vector construct containing the simian virus 40 large T antigen (SV40 TAg). We established a clonal epithelial cell line, referred to as PoCo83-3, that stably expressed the SV40 TAg, verified at mRNA and protein levels. PoCo83-3 showed epithelial cell-specific features, such as cobblestone-like morphology, dome structure formation, the presence of apical microvilli, and the expression of keratin 18, E-cadherin and the tight junction-associated proteins zonula occludens-1, occludin, and claudin-1. To validate PoCo83-3 as an in vitro model in epithelial barrier research, proinflammatory cytokine-inducible alterations in barrier integrity were demonstrated by incubating the cells with TNF-α and IFN-γ for 48 h. These cytokine treatments promoted a decreased transepithelial electrical resistance. In summary, PoCo83-3 exhibited an extended life span and a differentiated phenotype while maintaining epithelial characteristics. Based on these results, we present this cell line as a valuable in vitro model for investigations of epithelial barrier function in the porcine colon.
DOI: 10.6084/m9.figshare.4519643
title: Supplementary Material for: Short- and Long-Term Outcomes of Infliximab Treatment for Steroid-Refractory Ulcerative Colitis and Related Prognostic Factors: A Single-Center Retrospective Study

description: <b><i>Background/Aims:</i></b> The aim of this study was to analyze the short- and long-term outcomes of infliximab (IFX) treatment to cure steroid-refractory ulcerative colitis (UC) and related prognostic factors. <b><i>Methods:</i></b> Retrospective data were collected from 125 patients with steroid-refractory UC who received IFX treatment at our center from July 2005 to November 2013. The Lichtiger clinical activity index score was calculated at baseline, 2 weeks, 6 weeks, and 1 year, and the cumulative non-colectomy rate following IFX administration was estimated. Remission rate prognostic factors and the cumulative colectomy rate prognostic factors were evaluated using multivariate logistic regression analysis and multivariate Cox regression analysis, respectively. <b><i>Results:</i></b> Remission rates at 2 weeks, 6 weeks, and 1 year were 46, 58, and 45%, respectively. The 1-, 3-, and 5-year cumulative non-colectomy rates were 80, 78, and 75%, respectively. Previous treatment with calcineurin inhibitors was a significant prognostic factor for lower remission and cumulative non-colectomy rates, whereas concomitant immunomodulators was a significant prognostic factor for the higher remission rate. Gender (female) was a prognostic factor for higher remission rate at 1 year and higher cumulative non-colectomy rate. <b><i>Conclusions:</i></b> This study revealed good short- and long-term outcomes of IFX treatment in patients with steroid-refractory UC. Previous treatment with calcineurin inhibitors was a prognostic factor for poor outcomes of IFX treatment, whereas concomitant immunomodulators and gender (female) were prognostic factors for good outcomes.
DOI: 10.5281/zenodo.4012396
title: Ontolex-lemon and TIAD versions of Apertium Norwegian Nynorsk-Norwegian Bokmål dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2009-2019, Kevin Brubeck Unhammer 2019, Anja Zawadzka Persvold 2019, Jo Christian Oterhals 2008-2018, Trond Trosterud 2008-2011, Francis M. Tyers 2010, Sjur Nørstebø Moshagen 2008-2009, Jim O'Regan 2009, Jacob Nordfalk 2008, Frode Håvik Korneliussen
DOI: 10.5281/zenodo.4012395
title: Ontolex-lemon and TIAD versions of Apertium Norwegian Nynorsk-Norwegian Bokmål dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2009-2019, Kevin Brubeck Unhammer 2019, Anja Zawadzka Persvold 2019, Jo Christian Oterhals 2008-2018, Trond Trosterud 2008-2011, Francis M. Tyers 2010, Sjur Nørstebø Moshagen 2008-2009, Jim O'Regan 2009, Jacob Nordfalk 2008, Frode Håvik Korneliussen
DOI: 10.6084/m9.figshare.4519394
title: Classificação Qualis-Periódicos 2015 - Comunicação e Informação

description: Lista de Qualis-Periódicos 2015 da área de Comunicação e Informação
DOI: 10.6084/m9.figshare.4519394.v1
title: Periódicos Qualis 2015

description: Lista de Periódicos Qualis 2015 da área das Ciências Sociais Aplicadas 1 com Classificação A1
DOI: 10.5281/zenodo.4012394
title: Ontolex-lemon and TIAD versions of Apertium Maltese-Arabic dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2012-2014, Kevin Brubeck Unhammer 2012, Francis M. Tyers 2012, Maria Fronczak
DOI: 10.5281/zenodo.4012393
title: Ontolex-lemon and TIAD versions of Apertium Maltese-Arabic dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2012-2014, Kevin Brubeck Unhammer 2012, Francis M. Tyers 2012, Maria Fronczak
DOI: 10.6084/m9.figshare.4519301.v1
title: TABLA 1.

description: TABLA 1. Resultados. Excel.
DOI: 10.6084/m9.figshare.4519286
title: Week 3: Earth Analytics Light Detection and Ranging - Remote Sensing Teaching data subset

description: Light detection and ranging (Lidar) Remote sensing data for week 3 of class. The data are for the Lee Hill Area in Boulder, Colorado and include before and after terrain data.<br>
DOI: 10.5281/zenodo.4012390
title: Ontolex-lemon and TIAD versions of Apertium Macedonian-English dictionary

description: OntoLex-lemon and TSV conversion of Apertium Bidix. For more details, see https://www.aclweb.org/anthology/2020.lrec-1.401/ Authors of the original data: 2010-2012, Francis M. Tyers 2010, Jim O'Regan 2010, Trond Trosterud 2012-2013, Filip Petkovski 2012-2014, Kevin Brubeck Unhammer 2012, Anthony J. Bentley 2013, Lord_of_Life
DOI: 10.6084/m9.figshare.4519226
title: Smith_et_al_2015_GCB_PLFAsAbsoluteAbundance_PuertoRicoSoils_2010-1012

description: Small subset of relative and absolute abundance values for total PLFAs and from and PLFA biomarkers (indicator species) measured seasonally from sucessional forest soil in Puerto Rico from 2010-2012. Data used in select data analysis in doi/10.1111/gcb.12947Smith, A. Peyton, Erika Marín‐Spiotta, and Teri Balser. "Successional and seasonal variations in soil and litter microbial community structure and function during tropical postagricultural forest regeneration: a multiyear study." <i>Global change biology</i> 21.9 (2015): 3532-3547.
DOI: 10.6084/m9.figshare.4519286.v1
title: week 3 -lidar

description: REmote sensing data for week 3 of class<br>
DOI: 10.6084/m9.figshare.4519226.v1
title: Smith_et_al_2015_GCB_PLFAsAbsoluteAbundance_PuertoRicoSoils_2010-1012

description: Small subset of relative and absolute abundance values for total PLFAs and from and PLFA biomarkers (indicator species) measured seasonally from sucessional forest soil in Puerto Rico from 2010-2012. Data used in select data analysis in doi/10.1111/gcb.12947Smith, A. Peyton, Erika Marín‐Spiotta, and Teri Balser. "Successional and seasonal variations in soil and litter microbial community structure and function during tropical postagricultural forest regeneration: a multiyear study." <i>Global change biology</i> 21.9 (2015): 3532-3547.