cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7000586.v1
title: Bedaquiline- versus injectable-containing drug-resistant tuberculosis regimens: a cost-effectiveness analysis

description: <b>Background</b>: Drug-resistant tuberculosis (DR-TB) continues to be a major public health challenge with suboptimal treatment outcomes including well-documented treatment-related toxicities. We compared the cost-effectiveness of bedaquiline (BDQ) containing regimens with injectable containing regimens (short-course regimen [SCR] and long-course regimen [LCR]) in India, Russia, and South Africa. <b>Methods</b>: The analysis evaluated the direct costs of DR-TB treatment which included drugs, hospitalization, injectable-related adverse event costs, and other costs. Scenarios altered regimen costs, SCR/LCR ratio, and substitution rate between regimens (whether BDQ or injectable containing). <b>Results</b>: BDQ containing regimens are more cost effective based on cost per treatment success compared with injectable containing regimens, reducing these in SCR by 18–20% and in LCR by 49–54%. Average cost effectiveness ratios (ACERs) of BDQ containing regimens are lower. The incremental cost effectiveness ratio (ICER) is negative. Exclusive use of BDQ containing regimens results in approximately 61,000 more patients treated successfully over 5 years. <b>Conclusions</b>: Across all countries, BDQ containing regimens are dominant compared to injectable containing regimens, entailing lower treatment costs to achieve better clinical outcomes. This analysis can provide insight and support to local and global decision-makers and public health organizations to allocate efficiently resources improving patient and public health outcomes.
DOI: 10.6084/m9.figshare.7000598.v1
title: Nanoviscosity effect on the spin chemistry of an electron donor/Pt-complex /electron acceptor triad - classical and quantum kinetics interpretation

description: The magnetic-field dependent charge recombination kinetics upon ns-laser flash photolysis of a novel triarylamine/cyclometalated platinum complex/napthalenediimide triad (<b>DPtA</b>) have been measured in tetrahydrofuran (THF) and polytetrahydrofuran (pTHF) to study the spinchemical effect of a large increase of the macroviscosity of the solvent by a factor of about 1000. The magnetic-field dependence of the decay kinetics of the charge separated state has been accurately reproduced by a classical kinetic model, wherein the rate constants of transitions between spin substates of different Zeeman energy are represented by a single magnetic-field dependent rate constant <i>k</i><sub>±</sub>. In THF, the magnetic-field dependence of <i>k</i><sub>±</sub> is given by a double Lorentzian function which, in a double log plot, shows two characteristic steps that can be consistently assigned to the magnetic field inhibition of the coherent and incoherent i.e. relaxational spin mixing mechanism. In pTHF, the magnetic field effect on <i>k</i><sub>±</sub> is a single step function decreasing to its limiting value at about 5 times lower fields than in THF. As shown by a quantum theoretical simulation, in this solvent coherent and incoherent processes are contributing equally at all fields. The nanoviscosity of pTHF appears to be much smaller than its macroviscosity.
DOI: 10.6084/m9.figshare.7000577
title: The Cost of Multiple Representations: Preregistrations

description: Preregistration files from AsPredicted for the paper "The Cost of Multiple Representations: Learning Number Symbols with Abstract and Concrete Representations". Originals at:https://aspredicted.org/8wp6w.pdfhttps://aspredicted.org/tx92d.pdf<br><br>
DOI: 10.6084/m9.figshare.7000577.v1
title: The Cost of Multiple Representations: Preregistrations

description: Preregistration files from AsPredicted for the paper "The Cost of Multiple Representations: Learning Number Symbols with Abstract and Concrete Representations". Originals at:https://aspredicted.org/8wp6w.pdfhttps://aspredicted.org/tx92d.pdf<br><br>
DOI: 10.7284/104561
title: Multiplexed data collected during research cruise HRS110602CS using a Delaware SMS instrument system onboard the platform RV Hugh R. Sharp
DOI: 10.6084/m9.figshare.7000529
title: SAS Code from Cows are highly motivated to access a grooming substrate

description: Code used for statistical analysis (Kaplan-Meier Survival Analysis). Requires SAS.
DOI: 10.6084/m9.figshare.7000526
title: Experimental Data from Cows are highly motivated to access a grooming substrate

description: Excel sheet of the data used in statistical analysis. Data was collected by watching video footage of cows in the experimental pen. This is the input for the SAS Code (ESM2).
DOI: 10.6084/m9.figshare.7000523
title: Supplementary Material for: An hs-TNT Second Peak Associated with High CRP at Day 2 Appears as Potential Biomarkers of Micro-Vascular Occlusion on Magnetic Resonance Imaging after Reperfused ST-Segment Elevation Myocardial Infarction

description: <b><i>Introduction:</i></b> Micro-vascular occlusion (MVO) in a myocardial infarction (MI) is associated with an increased risk of heart failure and mortality. Hs-T-troponin has a double peak kinetic after MI. The aim was to determine if this kinetic was correlated to MVO evaluated by cardiac magnetic resonance imaging (MRI) after MI. <b><i>Methods:</i></b> This is a monocentric retrospective study. Inclusion criteria were hospitalization for MI, Thrombolysis In Myocardial Infarction flow 0 at coronary angiography, reperfusion within 12 h from the onset of chest pain, cardiac MRI within the first month, and a 5-days’ biological follow-up with at least hs-T-Troponin and C-reactive protein (CRP). Statistics were performed using the R software. <b><i>Results:</i></b> Ninety-eight patients were included. Fifty-three patients (54.1%) had MVO at MRI. The existence of MVO was associated with a trend of more kissing procedure during primary percutaneous coronary intervention (<i>p</i> = 0.06), a significantly more frequent second peak of troponin (<i>p</i> = 0.048), a significantly higher CRP level (<i>p</i> &lt; 0.0001) and a longer time to balloon (<i>p</i> = 0.01). The association of CRP level above 40 mg/L at day 2 and the observation of a second peak of troponin were associated to 95% of MVO in ST-segment elevation MI patients. By contrast, in the absence of these 2 criteria, MVO was absent in 78% of the cases. This score was associated with a higher rate of hospitalisation at 2 years. <b><i>Conclusion:</i></b> A biological score integrating hs-TNT second peak and CRP might help to predict MVO and predict outcomes after reperfused MI in our population.
DOI: 10.6084/m9.figshare.7000523.v1
title: Supplementary Material for: An hs-TNT Second Peak Associated with High CRP at Day 2 Appears as Potential Biomarkers of Micro-Vascular Occlusion on Magnetic Resonance Imaging after Reperfused ST-Segment Elevation Myocardial Infarction

description: <b><i>Introduction:</i></b> Micro-vascular occlusion (MVO) in a myocardial infarction (MI) is associated with an increased risk of heart failure and mortality. Hs-T-troponin has a double peak kinetic after MI. The aim was to determine if this kinetic was correlated to MVO evaluated by cardiac magnetic resonance imaging (MRI) after MI. <b><i>Methods:</i></b> This is a monocentric retrospective study. Inclusion criteria were hospitalization for MI, Thrombolysis In Myocardial Infarction flow 0 at coronary angiography, reperfusion within 12 h from the onset of chest pain, cardiac MRI within the first month, and a 5-days’ biological follow-up with at least hs-T-Troponin and C-reactive protein (CRP). Statistics were performed using the R software. <b><i>Results:</i></b> Ninety-eight patients were included. Fifty-three patients (54.1%) had MVO at MRI. The existence of MVO was associated with a trend of more kissing procedure during primary percutaneous coronary intervention (<i>p</i> = 0.06), a significantly more frequent second peak of troponin (<i>p</i> = 0.048), a significantly higher CRP level (<i>p</i> &lt; 0.0001) and a longer time to balloon (<i>p</i> = 0.01). The association of CRP level above 40 mg/L at day 2 and the observation of a second peak of troponin were associated to 95% of MVO in ST-segment elevation MI patients. By contrast, in the absence of these 2 criteria, MVO was absent in 78% of the cases. This score was associated with a higher rate of hospitalisation at 2 years. <b><i>Conclusion:</i></b> A biological score integrating hs-TNT second peak and CRP might help to predict MVO and predict outcomes after reperfused MI in our population.
DOI: 10.6084/m9.figshare.7000526.v1
title: Experimental Data from Cows are highly motivated to access a grooming substrate

description: Excel sheet of the data used in statistical analysis. Data was collected by watching video footage of cows in the experimental pen. This is the input for the SAS Code (ESM2).
DOI: 10.17637/rh.7000520.v1
title: Quantikz

description: A tikz library for those who want to typeset quantum circuit diagrams using LaTeX.<br>This code is currently at the beta testing stage.<br>
DOI: 10.6084/m9.figshare.7000508
title: Supplementary Material for: Epidemiology of Transthyretin Familial Amyloid Polyneuropathy in Portugal: A Nationwide Study

description: <b><i>Background:</i></b> Transthyretin-associated familial amyloid polyneuropathy (TTR-FAP) is a rare, hereditary, progressive and neurodegenerative disease. We aimed to study ­TTR-FAP epidemiology in Portugal. <b><i>Methods:</i></b> National, observational, prospective and retrospective, case identification of adults with TTR-FAP. Countrywide patient multiple identification sources included reference centers registries and centralized medical electronic prescription database. Crude rates were reported per 100,000 adult inhabitants. <b><i>Results:</i></b> Over 2010–2016 period, mean incidence rates was 0.87/100,000 (95% CI 0.68–1.10) corresponding to 71 new patients yearly, that has decreased 31% in the last 7 years. The proportion of late-onset cases (age ≥50 years) among incident cases was 28.7%. Estimated crude 2016 prevalence was 22.93/100,000 adult inhabitants (95% CI 21.90–23.99) corresponding to 1,865 TTR-FAP individuals in Portugal (45.8% male; mean age: 52.3 ± 15.4 years). In 2016, the Portuguese region with the highest TTR-FAP prevalence shows a 16% prevalence increase over the last 25 years. <b><i>Conclusions:</i></b> In Portugal, TTR-FAP affects both genders and mainly young adults. TTR-FAP incidence appears to be decreasing while prevalence is increasing. In comparison to previous studies, there is an increased representativeness of late-onset patients. This epidemiological setting poses future and complex challenges for the social and healthcare system, strengthening the relevance of regular epidemiologic surveillance.
DOI: 10.17637/rh.7000520.v2
title: Quantikz

description: A tikz library for those who want to typeset quantum circuit diagrams using LaTeX.<br>This code is currently at the beta testing stage.<br>
DOI: 10.17637/rh.7000520.v4
title: Quantikz

description: A tikz library for those who want to typeset quantum circuit diagrams using LaTeX.<br>This code is currently at the beta testing stage. Version 0.9.4. Now available through CTAN.<br>
DOI: 10.6084/m9.figshare.7000502
title: Supplementary Material for: Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

description: <b><i>Background:</i></b> Neuronal intermediates that communicate estrogen and progesterone feedback to gonadotropin-releasing hormone (GnRH) neurons are essential for modulating reproductive cyclicity. Individually, kisspeptin and nitric oxide (NO) influence GnRH secretion. However, it is possible these 2 neuronal intermediates interact with one another to affect reproductive cyclicity. <b><i>Methods:</i></b> We investigated the neuroanatomical relationship of one isoform of the enzyme that synthesizes NO, neuronal NO synthase (nNOS), to kisspeptin and GnRH in adult female rhesus monkeys and sheep using dual-label immunofluorescence. Additionally, we evaluated if the phase of the reproductive cycle would affect these relationships. <b><i>Results:</i></b> Overall, no effect of the stage of cycle was observed for any variable in this study. In the arcuate nucleus (ARC) of sheep, 98.8 ± 3.5% of kisspeptin neurons colocalized with nNOS, and kisspeptin close-contacts were observed onto nNOS neurons. In contrast to ewes, no colocalization was observed between kisspeptin and nNOS in the infundibular ARC of primates, but kisspeptin fibers were apposed to nNOS neurons. In the preoptic area of ewes, 15.0 ± 4.2% of GnRH neurons colocalized with nNOS. In primates, 38.8 ± 10.1% of GnRH neurons in the mediobasal hypothalamus colocalized with nNOS, and GnRH close-contacts were observed onto nNOS neurons in both sheep and primates. <b><i>Conclusion:</i></b> Although species differences were observed, this work establishes a neuroanatomical framework between nNOS and kisspeptin and nNOS and GnRH in adult female nonhuman primates and sheep.
DOI: 10.17637/rh.7000520.v3
title: Quantikz

description: A tikz library for those who want to typeset quantum circuit diagrams using LaTeX.<br>This code is currently at the beta testing stage. Version 0.9.2. Now available through CTAN.<br>
DOI: 10.6084/m9.figshare.7000499
title: Supplementary Material for: Peak Troponin I Levels Are Associated with Functional Outcome in Intracerebral Hemorrhage

description: <b><i>Background:</i></b> Troponin I is a widely used and reliable marker of myocardial damage and its levels are routinely measured in acute stroke care. So far, the influence of troponin I elevations during hospital stay on functional outcome in patients with atraumatic intracerebral hemorrhage (ICH) is unknown. <b><i>Methods:</i></b> Observational single-center study including conservatively treated ICH patients over a 9-year period. Patients were categorized according to peak troponin I level during hospital stay (≤0.040, 0.041–0.500, &gt; 0.500 ng/mL) and compared regarding baseline and hematoma characteristics. Multivariable analyses were performed to investigate independent associations of troponin levels during hospital stay with functional outcome – assessed using the modified Rankin Scale (mRS; favorable 0–3/unfavorable 4–6) – and mortality after 3 and 12 months. To account for possible confounding propensity score (PS)-matching (1: 1; caliper 0.1) was performed accounting for imbalances in baseline characteristics to investigate the impact of troponin I values on outcome. <b><i>Results:</i></b> Troponin elevations (&gt; 0.040 ng/mL) during hospital stay were observed in 308 out of 745 (41.3%) patients and associated with poorer status on admission (Glasgow Coma Scale/National Institute of Health Stroke Scale). Multivariable analysis revealed troponin I levels during hospital stay to be independently associated with unfavorable outcome after 12 months (risk ratio [95% CI]: 1.030 [1.009–1.051] per increment of 1.0 ng/mL; <i>p</i> = 0.005), but not with mortality. After PS-matching, patients with troponin I elevation (≥0.040 ng/mL) versus those without had a significant higher rate of ­unfavorable outcome after 3 and 12 months (mRS 4–6 at 3 months: &lt; 0.04 ng/mL: 159/265 [60.0%] versus ≥0.04 ng/mL: 199/266 [74.8%]; <i>p</i> &lt; 0.001; at 12 months: &lt; 0.04 ng/mL: 141/248 [56.9%] versus ≥0.04 ng/mL: 179/251 [71.3%]; <i>p</i> = 0.001). <b><i>Conclusions:</i></b> Troponin I elevations during hospital stay occur frequently in ICH patients and are independently associated with functional outcome after 3 and 12 months but not with mortality.
DOI: 10.6084/m9.figshare.7000502.v1
title: Supplementary Material for: Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

description: <b><i>Background:</i></b> Neuronal intermediates that communicate estrogen and progesterone feedback to gonadotropin-releasing hormone (GnRH) neurons are essential for modulating reproductive cyclicity. Individually, kisspeptin and nitric oxide (NO) influence GnRH secretion. However, it is possible these 2 neuronal intermediates interact with one another to affect reproductive cyclicity. <b><i>Methods:</i></b> We investigated the neuroanatomical relationship of one isoform of the enzyme that synthesizes NO, neuronal NO synthase (nNOS), to kisspeptin and GnRH in adult female rhesus monkeys and sheep using dual-label immunofluorescence. Additionally, we evaluated if the phase of the reproductive cycle would affect these relationships. <b><i>Results:</i></b> Overall, no effect of the stage of cycle was observed for any variable in this study. In the arcuate nucleus (ARC) of sheep, 98.8 ± 3.5% of kisspeptin neurons colocalized with nNOS, and kisspeptin close-contacts were observed onto nNOS neurons. In contrast to ewes, no colocalization was observed between kisspeptin and nNOS in the infundibular ARC of primates, but kisspeptin fibers were apposed to nNOS neurons. In the preoptic area of ewes, 15.0 ± 4.2% of GnRH neurons colocalized with nNOS. In primates, 38.8 ± 10.1% of GnRH neurons in the mediobasal hypothalamus colocalized with nNOS, and GnRH close-contacts were observed onto nNOS neurons in both sheep and primates. <b><i>Conclusion:</i></b> Although species differences were observed, this work establishes a neuroanatomical framework between nNOS and kisspeptin and nNOS and GnRH in adult female nonhuman primates and sheep.
DOI: 10.6084/m9.figshare.7000487
title: Supplementary Material for: Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions

description: <b><i>Background:</i></b> Ginseng has been used to improve brain function and increase longevity. However, little is known about the ingredients of ginseng and molecular mechanisms of its anti-brain aging effects. Gintonin is a novel exogenous ginseng-derived lysophosphatidic acid (LPA) receptor ligand; LPA and LPA1 receptors are involved in adult hippocampal neurogenesis. D-galactose (D-gal) is used to induce brain ­aging in animal models because long-term treatment with D-gal facilitates hippocampal aging in experimental adult animals by decreasing hippocampal neurogenesis and inducing learning and memory dysfunction. <b><i>Objective:</i></b> To investigate the protective effects of gintonin on D-gal-induced hippocampal senescence, impairment of long-term potentiation (LTP), and memory dysfunction. <b><i>Methods:</i></b> Brain hippocampal aging was induced by D-gal administration (150 mg/kg/day, s.c.; 10 weeks). From the 7th week, gintonin (50 or 100 mg/kg/day, per os) was co-administered with D-gal for 4 weeks. We performed histological analyses, LTP measurements, and object location test. <b><i>Results:</i></b> Co-administration of gintonin ameliorated D-gal-induced reductions in hippocampal Ki67-immunoreactive proliferating cells, doublecortin-immunoreactive neuroblasts, 5-bromo-2’-deoxyuridine-incorporating NeuN-immunoreactive mature neurons, and LPA1 receptor expression. Co-administration of gintonin in D-gal-treated mice increased the expression of phosphorylated cyclic adenosine monophosphate response element binding protein in the hippocampal dentate gyrus. In addition, co-administration of gintonin in D-gal-treated mice enhanced LTP and restored the cognitive functions compared with those in mice treated with D-gal only. <b><i>Conclusion:</i></b> These results show that gintonin administration restores D-gal-induced memory deficits by enhancing hippocampal LPA1 receptor expression, LTP, and neurogenesis. Finally, the present study shows that gintonin exerts anti-brain aging effects that are responsible for alleviating brain aging-related dysfunction.
DOI: 10.6084/m9.figshare.7000487.v1
title: Supplementary Material for: Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions

description: <b><i>Background:</i></b> Ginseng has been used to improve brain function and increase longevity. However, little is known about the ingredients of ginseng and molecular mechanisms of its anti-brain aging effects. Gintonin is a novel exogenous ginseng-derived lysophosphatidic acid (LPA) receptor ligand; LPA and LPA1 receptors are involved in adult hippocampal neurogenesis. D-galactose (D-gal) is used to induce brain ­aging in animal models because long-term treatment with D-gal facilitates hippocampal aging in experimental adult animals by decreasing hippocampal neurogenesis and inducing learning and memory dysfunction. <b><i>Objective:</i></b> To investigate the protective effects of gintonin on D-gal-induced hippocampal senescence, impairment of long-term potentiation (LTP), and memory dysfunction. <b><i>Methods:</i></b> Brain hippocampal aging was induced by D-gal administration (150 mg/kg/day, s.c.; 10 weeks). From the 7th week, gintonin (50 or 100 mg/kg/day, per os) was co-administered with D-gal for 4 weeks. We performed histological analyses, LTP measurements, and object location test. <b><i>Results:</i></b> Co-administration of gintonin ameliorated D-gal-induced reductions in hippocampal Ki67-immunoreactive proliferating cells, doublecortin-immunoreactive neuroblasts, 5-bromo-2’-deoxyuridine-incorporating NeuN-immunoreactive mature neurons, and LPA1 receptor expression. Co-administration of gintonin in D-gal-treated mice increased the expression of phosphorylated cyclic adenosine monophosphate response element binding protein in the hippocampal dentate gyrus. In addition, co-administration of gintonin in D-gal-treated mice enhanced LTP and restored the cognitive functions compared with those in mice treated with D-gal only. <b><i>Conclusion:</i></b> These results show that gintonin administration restores D-gal-induced memory deficits by enhancing hippocampal LPA1 receptor expression, LTP, and neurogenesis. Finally, the present study shows that gintonin exerts anti-brain aging effects that are responsible for alleviating brain aging-related dysfunction.
DOI: 10.6084/m9.figshare.7000466
title: PSMA_BoneMetastases.csv

description: Comparison of uptake in unaffected bone tissue of PSMA PET tracers [18F]-DCFPyL and [68Ga]-HBED-CC.
DOI: 10.6084/m9.figshare.7000466.v1
title: PSMA_BoneMetastases.csv

description: Comparison of uptake in unaffected bone tissue of PSMA PET tracers [18F]-DCFPyL and [68Ga]-HBED-CC.
DOI: 10.6084/m9.figshare.7000451
title: Supplementary Material for: Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients

description: <b><i>Objective:</i></b> To evaluate the prognostic potential of expression levels of miR-200 family members (miR-200a, miR-200b, miR-200c, miR-429, miR-141) in plasma and exosomes from the tumor-draining vein (mesenteric vein [MV]) and peripheral vein (PV) of colon cancer (CC) patients. <b><i>Methods:</i></b> We analyzed the expression of miR-200 family members in matched samples of MV and PV plasma from 50 resected patients with CC and correlated our findings with overall survival (OS). We also examined the content of these microRNAs in MV and PV exosomes. <b><i>Results:</i></b> Expression levels were higher in MV than in PV (miR-200a, <i>p</i> &lt; 0.001; miR-200b, <i>p</i> &lt; 0.001; miR-429, <i>p</i> = 0.01; miR-200c, <i>p</i> = 0.05; miR-141, <i>p</i> = 0.05). Low levels of both miR-200c and miR-141 in MV plasma were associated with longer OS (<i>p</i> = 0.02). This association was maintained for the MV exosome cargo of miR-200c and miR-141 (<i>p</i> = 0.02). <b><i>Conclusion:</i></b> Our findings provide the first indication that expression levels of miR-200c and miR-141 in MV plasma can identify CC patients with poor prognosis. In addition, our results lend further support to the premise that tumor-draining veins constitute a better source of biomarkers than do PVs.