cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18188281
title: Anesthesia Choices in Cardio-Oncology: Conscious Sedation Versus General Anesthesia for Percutaneous Left Atrial Appendage Occlusion in Cancer Patients - A Systematic Review and Meta-Analysis

description: Abstract

Background

Cardio-oncology has emerged as a critical subspecialty addressing the

intersection of cardiovascular disease and cancer, particularly in patients with

atrial fibrillation (AF) who require interventions like percutaneous left atrial

appendage occlusion (PLAAO) to mitigate stroke risk. The choice of

anesthesia—conscious sedation (CS) versus general anesthesia (GA)—

remains debated, especially in oncology patients susceptible to treatment-

related cardiotoxicity. This systematic review and meta-analysis evaluates the

efficacy, safety, and outcomes of CS compared to GA in PLAAO procedureswithin a cardio-oncology context.

Methods

We conducted a comprehensive search of databases including PubMed,

Embase, Cochrane Library, and Scopus up to December 2025, focusing on

studies involving cancer patients undergoing PLAAO. Inclusion criteria

encompassed randomized controlled trials (RCTs), observational studies, and

cohort analyses comparing CS and GA. Primary outcomes included

procedural success, periprocedural complications, and cardiovascular events

linked to oncologic therapies. Risk of bias was assessed using the Cochrane

RoB 2 tool and Newcastle-Ottawa Scale. Meta-analyses were performed

using random-effects models, with heterogeneity evaluated via I² statistics.

Results

From 1,456 screened articles, 28 studies involving 4,872 patients (2,315 with

CS and 2,557 with GA) were included. CS was associated with shorter

procedure times (mean difference [MD] -15.2 minutes; 95% CI -20.1 to -10.3;

P<0.001) and reduced hospital stays (MD -0.8 days; 95% CI -1.2 to -0.4;

P=0.002). In cardio-oncology subsets, CS showed lower rates of

anthracycline-related cardiomyopathy exacerbation (odds ratio [OR] 0.62;

95% CI 0.45-0.85; P=0.003). However, GA provided better hemodynamic

stability in patients with radiation-induced valvular disease (OR 1.35; 95% CI

1.12-1.62; P=0.01). Overall complication rates were similar (OR 0.89; 95% CI

0.72-1.10; P=0.28), with moderate heterogeneity (I²=42%).

Conclusions

In cardio-oncology patients undergoing PLAAO, CS offers advantages in

efficiency and reduced cardiotoxic burden, while GA may be preferable for

those with complex comorbidities. Tailored anesthesia selection is essential

to optimize outcomes in this vulnerable population.

Keywords: Cardio-oncology, percutaneous left atrial appendage occlusion,

conscious sedation, general anesthesia, systematic review, meta-analysis.
DOI: 10.5281/zenodo.18188280
title: Anesthesia Choices in Cardio-Oncology: Conscious Sedation Versus General Anesthesia for Percutaneous Left Atrial Appendage Occlusion in Cancer Patients - A Systematic Review and Meta-Analysis

description: Abstract

Background

Cardio-oncology has emerged as a critical subspecialty addressing the

intersection of cardiovascular disease and cancer, particularly in patients with

atrial fibrillation (AF) who require interventions like percutaneous left atrial

appendage occlusion (PLAAO) to mitigate stroke risk. The choice of

anesthesia—conscious sedation (CS) versus general anesthesia (GA)—

remains debated, especially in oncology patients susceptible to treatment-

related cardiotoxicity. This systematic review and meta-analysis evaluates the

efficacy, safety, and outcomes of CS compared to GA in PLAAO procedureswithin a cardio-oncology context.

Methods

We conducted a comprehensive search of databases including PubMed,

Embase, Cochrane Library, and Scopus up to December 2025, focusing on

studies involving cancer patients undergoing PLAAO. Inclusion criteria

encompassed randomized controlled trials (RCTs), observational studies, and

cohort analyses comparing CS and GA. Primary outcomes included

procedural success, periprocedural complications, and cardiovascular events

linked to oncologic therapies. Risk of bias was assessed using the Cochrane

RoB 2 tool and Newcastle-Ottawa Scale. Meta-analyses were performed

using random-effects models, with heterogeneity evaluated via I² statistics.

Results

From 1,456 screened articles, 28 studies involving 4,872 patients (2,315 with

CS and 2,557 with GA) were included. CS was associated with shorter

procedure times (mean difference [MD] -15.2 minutes; 95% CI -20.1 to -10.3;

P<0.001) and reduced hospital stays (MD -0.8 days; 95% CI -1.2 to -0.4;

P=0.002). In cardio-oncology subsets, CS showed lower rates of

anthracycline-related cardiomyopathy exacerbation (odds ratio [OR] 0.62;

95% CI 0.45-0.85; P=0.003). However, GA provided better hemodynamic

stability in patients with radiation-induced valvular disease (OR 1.35; 95% CI

1.12-1.62; P=0.01). Overall complication rates were similar (OR 0.89; 95% CI

0.72-1.10; P=0.28), with moderate heterogeneity (I²=42%).

Conclusions

In cardio-oncology patients undergoing PLAAO, CS offers advantages in

efficiency and reduced cardiotoxic burden, while GA may be preferable for

those with complex comorbidities. Tailored anesthesia selection is essential

to optimize outcomes in this vulnerable population.

Keywords: Cardio-oncology, percutaneous left atrial appendage occlusion,

conscious sedation, general anesthesia, systematic review, meta-analysis.
DOI: 10.6084/m9.figshare.30593345
title: Thermothelomyces thermophilus germination assay images: ∆ku80 and mutants, ∆ku80 Zinc, ∆zip zinc assay

description: Germination assay microscopy images:<br>-Temperature dependent 10 hour germination assays of Thermothelomyces thermophilus ∆ku80 and mutant library grown at 37C, 45C and 50C.<br>-Temperature dependent 10 hour germination assay of Thermothelomyces thermophilus ∆ku80 grown in Vogels minimal medium with varying concentrations of Zinc. Grown at 37C and 50C.<br>-Temperature dependent 10 hour germination assay of Thermothelomyces thermophilus ∆zip mutant grown in Vogels minimal medium with varying concentrations of Zinc. Grown at 37C and 50C.<br>
DOI: 10.6084/m9.figshare.30593345.v1
title: Thermothelomyces thermophilus germination assay images: ∆ku80 and mutants, ∆ku80 Zinc

description: Germination assay microscopy images:<br>Temperature dependent 10 hour germination assays of Thermothelomyces thermophilus ∆ku80 and mutant library grown at 37C, 45C and 50C.<br>Temperature dependent 10 hour germination assay of Thermothelomyces thermophilus ∆ku80 grown in Vogels minimal medium with varying concentrations of Zinc. Grown at 37C and 50C.
DOI: 10.6084/m9.figshare.30593345.v2
title: Thermothelomyces thermophilus germination assay images: ∆ku80 and mutants, ∆ku80 Zinc, ∆zip zinc assay

description: Germination assay microscopy images:<br>-Temperature dependent 10 hour germination assays of Thermothelomyces thermophilus ∆ku80 and mutant library grown at 37C, 45C and 50C.<br>-Temperature dependent 10 hour germination assay of Thermothelomyces thermophilus ∆ku80 grown in Vogels minimal medium with varying concentrations of Zinc. Grown at 37C and 50C.<br>-Temperature dependent 10 hour germination assay of Thermothelomyces thermophilus ∆zip mutant grown in Vogels minimal medium with varying concentrations of Zinc. Grown at 37C and 50C.<br>
DOI: 10.71650/datapb/s1gmme
title: Gastrópodes Terrestres da Paraíba

description: O presente Dataset trata dos Gastropoda (Filo Mollusca) terrestres do estado da Paraíba. Estão listados nesse Dataset,12 famílias, 10 subfamílias, 21 gêneros e 27 espécies de caracóis e lesmas, coletados em ambientes de Mata Atlântica e Caatinga. O material esta depositado na coleção malacológica do LABEC (Laboratório de Ensino de Ciências) do Centro de Educação da Universidade Federal da Paraíba. Estes dados fornecem informações sobre a ocorrência e distribuição geográfica das diferentes espécies para o estado da Paraíba.
DOI: 10.15468/dl.qaqpez
title: Occurrence Download

description: A dataset containing 2891 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Biatas nigropectus"
 ]
}

 The dataset includes 2891 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082041-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bcpgug
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Laticauda guineai"
 ]
}

 The dataset includes 17 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082042-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.csqdgp
title: Occurrence Download

description: A dataset containing 30 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"within","geometry":"POLYGON ((73.184726 23.827186, 73.107962 23.821609, 73.033106 23.805017, 72.96202099999999 23.777823, 72.896469 23.740701, 72.83807400000001 23.694575, 72.788276 23.640589, 72.74829699999999 23.58008, 72.719114 23.514546, 72.701431 23.445607, 72.695666 23.374965, 72.701943 23.304359, 72.720088 23.235526, 72.74963700000001 23.170159, 72.789851 23.109859, 72.83973 23.056105, 72.898045 23.010211, 72.96336100000001 22.9733, 73.03408 22.946271, 73.108473 22.929786, 73.184726 22.924246, 73.26097900000001 22.929786, 73.33537200000001 22.946271, 73.406091 22.9733, 73.471407 23.010211, 73.52972200000001 23.056105, 73.579601 23.109859, 73.619815 23.170159, 73.64936400000001 23.235526, 73.667509 23.304359, 73.67378600000001 23.374965, 73.668021 23.445607, 73.650338 23.514546, 73.621155 23.58008, 73.581176 23.640589, 73.531378 23.694575, 73.472983 23.740701, 73.407431 23.777823, 73.33634600000001 23.805017, 73.26148999999999 23.821609, 73.184726 23.827186))"},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 30 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082043-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5n29pm2t
title: MassIVE MSV000100417 - LC-MS based metabolite profiling of liver tissue from septic and control mice
title: Liver tissue from wild-type C57BL6J mice subjected to cecal slurry induced sepsis vs. glycerol vehicle was analyzed by LCMS to assess metabolic alterations. The dataset includes raw mzML files generated to examine changes in glycolytic and tricarboxylic acid (TCA) cycle intermediates as part of a mechanistic sepsis study.
DOI: 10.18738/t8/nmqa1n
title: Buildings of Texas (Beta v. 0.2)
title: Buildings of Texas (Points) v. 2

description: The Buildings of Texas collection contains source materials for the Society of Architectural Historian’s two-volume publication “The Buildings of Texas.” Data gathered by the research team and donated as part of the collection includes information about people, places, and events across the state.

Dataset produced from the spreadsheet donated by Gerald Moorhead and created by researchers collecting data for the publication. See the Buildings of Texas original dataset for the dataset as received: https://doi.org/10.18738/T8/M45YL8. 
&lt;br&gt;
&lt;br&gt;
&lt;b&gt;Buildings of Texas V1 is the most complete, accurate, and enhanced version of the data, while beta versions represent works in progress.&lt;/b&gt; 
&lt;br&gt;
&lt;br&gt;
In Beta v. 0.1, Architects and other contributor names have been normalized and building types have been added to portions of the dataset. Built works with identifiable locations have been geocoded. Version 1: https://doi.org/10.18738/T8/YIGGX7.

In Beta v. 0.2: Information about places and people/firms described in this dataset have been reconciled with Wikidata and a new field was added to record Wikidata ID information. Building typologies were significantly improved. Field names have changed.
DOI: 10.18738/t8/yiggx7
title: Buildings of Texas (Beta v. 0.1)
title: Building of Texas (Points) v. 1

description: The Buildings of Texas collection contains source materials for the Society of Architectural Historian’s two-volume publication “The Buildings of Texas.” Data gathered by the research team and donated as part of the collection includes information about people, places, and events across the state.

Dataset produced from the spreadsheet donated by Gerald Moorhead and created by researchers collecting data for the publication. See the Buildings of Texas original dataset for the dataset as received: https://doi.org/10.18738/T8/M45YL8. 
&lt;br&gt;
&lt;br&gt;
&lt;b&gt;Buildings of Texas V1 is the most complete, accurate, and enhanced version of the data, while beta versions represent works in progress.&lt;/b&gt; 
&lt;br&gt;
&lt;br&gt;
In Beta v. 0.1, Architects and other contributor names have been normalized and building types have been added to portions of the dataset. Built works with identifiable locations have been geocoded.
DOI: 10.15468/dl.rzjt7x
title: Occurrence Download

description: A dataset containing 30 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"within","geometry":"POLYGON ((73.184726 23.827186, 73.107962 23.821609, 73.033106 23.805017, 72.96202099999999 23.777823, 72.896469 23.740701, 72.83807400000001 23.694575, 72.788276 23.640589, 72.74829699999999 23.58008, 72.719114 23.514546, 72.701431 23.445607, 72.695666 23.374965, 72.701943 23.304359, 72.720088 23.235526, 72.74963700000001 23.170159, 72.789851 23.109859, 72.83973 23.056105, 72.898045 23.010211, 72.96336100000001 22.9733, 73.03408 22.946271, 73.108473 22.929786, 73.184726 22.924246, 73.26097900000001 22.929786, 73.33537200000001 22.946271, 73.406091 22.9733, 73.471407 23.010211, 73.52972200000001 23.056105, 73.579601 23.109859, 73.619815 23.170159, 73.64936400000001 23.235526, 73.667509 23.304359, 73.67378600000001 23.374965, 73.668021 23.445607, 73.650338 23.514546, 73.621155 23.58008, 73.581176 23.640589, 73.531378 23.694575, 73.472983 23.740701, 73.407431 23.777823, 73.33634600000001 23.805017, 73.26148999999999 23.821609, 73.184726 23.827186))"},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 30 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082044-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n8g5ae
title: Occurrence Download

description: A dataset containing 924 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-180 -10,180 -10,180 10,-180 10,-180 -10))",
 "TaxonKey is Carcharhinus longimanus"
 ]
}

 The dataset includes 924 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082045-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18188412
title: Microfluidic-Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo-Lysosomal Trafficking Optimization [Physicochemical Characterization]

description: Physicochemical Characterization of Microfluidic-Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo-Lysosomal Trafficking Optimization
DOI: 10.5281/zenodo.18188413
title: Microfluidic-Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo-Lysosomal Trafficking Optimization [Physicochemical Characterization]

description: Physicochemical Characterization of Microfluidic-Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo-Lysosomal Trafficking Optimization
DOI: 10.15468/dl.bskcup
title: Occurrence Download

description: A dataset containing 30 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"within","geometry":"POLYGON ((73.158978 23.819026, 73.082218 23.813449, 73.007368 23.796857, 72.93628699999999 23.769662, 72.870739 23.732541, 72.812348 23.686415, 72.762552 23.632428, 72.722576 23.571919, 72.693395 23.506386, 72.675713 23.437447, 72.66994800000001 23.366804, 72.676224 23.296198, 72.694368 23.227365, 72.723916 23.161998, 72.764127 23.101698, 72.814003 23.047944, 72.872314 23.00205, 72.93762599999999 22.965138, 73.008341 22.93811, 73.08273 22.921625, 73.158978 22.916084, 73.235226 22.921625, 73.30961499999999 22.93811, 73.38033 22.965138, 73.44564200000001 23.00205, 73.503953 23.047944, 73.55382899999999 23.101698, 73.59404000000001 23.161998, 73.623588 23.227365, 73.641732 23.296198, 73.648008 23.366804, 73.64224299999999 23.437447, 73.624561 23.506386, 73.59538000000001 23.571919, 73.555404 23.632428, 73.505608 23.686415, 73.44721699999999 23.732541, 73.381669 23.769662, 73.310588 23.796857, 73.235738 23.813449, 73.158978 23.819026))"},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 30 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082047-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18188446
title: Why systems that work correctly still fail

description: Why systems that work correctly still fail Many modern systems fail in ways that are difficult to explain, not because they are poorly designed, but because they work well for a long time.
DOI: 10.5281/zenodo.18188447
title: Why systems that work correctly still fail

description: Why systems that work correctly still fail Many modern systems fail in ways that are difficult to explain, not because they are poorly designed, but because they work well for a long time.
DOI: 10.15468/dl.58ydaq
title: Occurrence Download

description: A dataset containing 4969 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is one of (Butea monosperma, Butea monosperma)"
 ]
}

 The dataset includes 4969 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082048-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w8hred
title: Occurrence Download

description: A dataset containing 142 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Specimen)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Ficus cyclophylla",
 "Year 1970-2026"
 ]
}

 The dataset includes 142 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082049-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gk7c7q
title: Occurrence Download

description: A dataset containing 30 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"within","geometry":"POLYGON ((73.249882 23.750035, 73.173163 23.744458, 73.09835200000001 23.727866, 73.027308 23.700671, 72.961795 23.66355, 72.90343300000001 23.617424, 72.85366399999999 23.563437, 72.81370800000001 23.502928, 72.784541 23.437394, 72.766867 23.368455, 72.761105 23.297811, 72.767377 23.227205, 72.78551 23.158372, 72.81504200000001 23.093003, 72.855232 23.032703, 72.905083 22.978947, 72.963363 22.933053, 73.028643 22.89614, 73.099321 22.869111, 73.17367299999999 22.852626, 73.249882 22.847085, 73.32609100000001 22.852626, 73.400443 22.869111, 73.471121 22.89614, 73.536401 22.933053, 73.59468099999999 22.978947, 73.644532 23.032703, 73.68472199999999 23.093003, 73.714254 23.158372, 73.732387 23.227205, 73.738659 23.297811, 73.73289699999999 23.368455, 73.71522299999999 23.437394, 73.68605599999999 23.502928, 73.6461 23.563437, 73.59633100000001 23.617424, 73.537969 23.66355, 73.47245599999999 23.700671, 73.40141199999999 23.727866, 73.326601 23.744458, 73.249882 23.750035))"},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 30 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082051-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u3sdzj
title: Occurrence Download

description: A dataset containing 1778 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Aipysurus laevis"
 ]
}

 The dataset includes 1778 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0082050-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18188386
title: Éxito y azar: un modelo basado en agentes sobre la influencia del talento, la suerte y otros factores
DOI: 10.5281/zenodo.18188385
title: Éxito y azar: un modelo basado en agentes sobre la influencia del talento, la suerte y otros factores