cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.8014373
title: Co-Creation Methods Inventory: Sourced from Academic and Grey Literature

description: Introducing the Co-Creation Methods Inventory. Discover an open-access dataset containing a vast collection of co-creation methods. This resource is the culmination of meticulous research and ongoing analysis, drawing from diverse co-creation projects and references. Within this dataset, you will find 765 co-creation methods sourced from the Health CASCADE Co-Creation Database and grey literature sources. Each method is accompanied by a description and a reference.

This initial dataset is meticulously curated to support and enhance your co-creation processes. Whether you are engaged in co-creation, co-design, co-production, or participatory research, these methods offer valuable insights and approaches. This dataset is a precursor to the forthcoming academic articles by Agnello DM et al., scheduled for publication in 2024.

For any inquiries or further information about the dataset, please feel free to reach out to Danielle Marie Agnello at danielle.agnello@gcu.ac.uk. Additionally, join the conversation and stay updated on her work by following her on Twitter: https://twitter.com/DannyAgnello_GH. To delve deeper into the Health CASCADE Co-Creation Database, follow this link: https://doi.org/10.2196/45059. For additional support in utilizing these co-creation methods, explore our Draft Evidence-based Co-Creation Guideline: PRODUCES+ at https://doi.org/10.5281/zenodo.7343029. Finally, if you're interested in understanding more about how these methods align with co-creation characteristics, please take a look at this pre-print manuscript about the Co-Creation Rainbow framework: https://zenodo.org/records/10391410.  

Unlock the potential of co-creation methods and embark on a collaborative research journey with confidence, creativity and innovation!
DOI: 10.5281/zenodo.8188683
title: Raw video and pose estimation data of top view open field mouse behavior recordings after yohimbine injections

description: This repository contains raw data for 32 different open field recordings of mice. these include top view raw video .mp4 files (Videos.zip) and the corresponding .csv pose estimation data (data.zip) obtained with DeepLabCut. The data is from a single yohimbine injection experiment at Roche, where animals were injected with saline, 1mg/kg,3mg/kg or 6mg/kg of yohimbine. The METADATA.csv or METADATA.xlsx files contain all grouping variables and help linking the pose estimation files (located in data/Yohimbine_Roche) to the video files. Visit https://github.com/ETHZ-INS/BehaviorFlow to find out more about how we have used this data
DOI: 10.6084/m9.figshare.22321129.v1
title: DailyGWL.xlsx

description: Daily groundwater level data meaured at undrained and drained tropical peat swamp forests (PSFs) near Palangkaraya, Central Kalimantan, Indonesia from 2015 to 2018 at the undrained PSF and from 2013 to 2017 at the drained PSF. The mothod is given by the references.
DOI: 10.6084/m9.figshare.24305557
title: <b>A benchmark </b><b>GaoFen-7 </b><b>dataset for building extraction from satellite images</b>

description: This study constructs a high-resolution (0.65 m) GaoFen-7 (GF-7) Building dataset utilizing the Chinese GF-7 imagery from Tianjin, Lanzhou, Chongqing, Ningbo, Guangzhou, and Shenzhen. The dataset comprises 5175 pairs of 512×512 image tiles (including 3106 pairs in the training set, 1034 pairs in the validation set, and 1035 pairs in the test set), totally covering an area of 573.17 km<sup>2</sup> in China. It contains a total of 170,015 buildings, out of which 145,327 buildings (84.8%) are distributed in urban areas, while the remaining 24,688 buildings (15.2%) are distributed across rural areas. These high-quality labels are mainly generated through manual digitization.
DOI: 10.6084/m9.figshare.27157593.v1
title: Supporting data of "<b>UNCOVERING BACTERIAL-MAMMALIAN CELL INTERACTIONS VIA SINGLE-CELL TRACKING</b>" article

description: This data supports the "<b>UNCOVERING BACTERIAL-MAMMALIAN CELL INTERACTIONS VIA SINGLE-CELL TRACKING</b>" paper published in BMC Biology
DOI: 10.6084/m9.figshare.27201630
title: Supplementary Material for: Prevention and treatment of neonatal infections in facility and community settings of low- and middle-income countries: a descriptive review

description: Background We present a robust and up-to-date synthesis of evidence on the effectiveness of interventions to prevent and treat newborn infections in low- and middle-income countries (LMICs). Newborn infection prevention interventions included strategies to reduce antimicrobial resistance (AMR), prevention of healthcare-associated infections (HAIs), clean birth kits (CBKs), chlorhexidine cleansing, topical emollients, and probiotics and synbiotics supplementation. Interventions to treat suspected neonatal infections included prophylactic systemic antifungal agents and community-based antibiotic delivery for possible serious bacterial infections (PSBIs). 
Summary A descriptive review combining different methodological approaches was conducted. To provide the most suitable recommendations for real-world implementation, our analyses considered the impact of these interventions within three distinct health settings: facility, mixed, and community. In facility settings, the strongest evidence supported the implementation of multimodal stewardship interventions for AMR reduction and device-associated infection prevention bundles for HAI prevention. Emollients in preterm newborns reduced the risk of invasive infection compared to routine skin care. Probiotics in preterm newborns reduced neonatal mortality risk, invasive infection, and necrotizing enterocolitis (NEC) compared to standard care or placebo. There was insufficient evidence for synbiotics and prophylactic systemic antifungals in LMICs. In mixed settings, CBKs reduced neonatal mortality risk compared to standard care. In community settings, chlorhexidine umbilical cord cleansing reduced omphalitis risk compared to dry cord care. For the treatment of PSBIs, purely domiciliary-based antibiotic delivery reduced the risk of all-cause neonatal mortality when compared to the standard hospital referral. 
Key Messages Strategies for preventing HAIs and reducing AMR in healthcare facilities should be multimodal, and strategy selection should consider the feasibility of integration within existing newborn care programs. Probiotics are effective for facility-based use in preterm newborns; however, the establishment of high-quality, cost-effective mass production of standardized formulations is needed. Chlorhexidine cord cleansing is effective in community settings to prevent omphalitis in contexts where unhygienic cord applications are prevalent. Community-based antibiotic delivery of simplified regimens for PSBIs is a safe alternative when hospital-based care in LMICs is not possible or is declined by parents. More randomized trial evidence is needed to establish the effectiveness of CBKs, emollients, synbiotics, and prophylactic systemic antifungals in LMICs.
DOI: 10.6084/m9.figshare.27246606
title: Supplementary Material for: Mastery learning guided by AI is superior to directed self-regulated learning in flexible bronchoscopy training – an RCT.

description: Introduction: Simulation-based training has proven effective for learning flexible bronchoscopy. However, no studies have tested the efficacy of training towards established proficiency criteria i.e., mastery learning (ML). We wish to test the effectiveness of ML compared to Directed Self-Regulated Learning (DSRL) on novice bronchoscopists’ end-of-training performance.
Methods: In a standardized simulated setting, novices without prior bronchoscopy experience trained using an artificial intelligence (AI) guidance system that automatically recognizes the bronchial segments. They were randomized into two groups: the ML group and the DSRL group. The ML group trained until they completed two procedures meeting the proficiency targets: 18 inspected segments, 18 structured progressions, &lt;120 seconds procedure time. The DSRL group trained until they no longer perceived any additional benefits from training. Both groups then did a finalizing test, without the AI-guidance enabled. 
Results: 24 participants completed the study, with 12 in each group. Both groups had a high mean number of inspected segments (ML=17.2 segments, DSRL=17.3 segments, P=.85) and structured progressions (ML=15.5 progressions, DSRL=14.8 progressions, P=.58), but the ML group performed the test procedure significantly faster (ML=107 seconds, DSRL=180 seconds, P&lt;.001). The ML did not spend significantly longer time training (ML=114 minutes, DSRL=109 minutes, P=.84).
Conclusions: ML is a very efficient training form allowing novice trainees to learn how to perform a thorough, systematic, and quick flexible bronchoscopy. ML does not require longer time spent training compared to DSRL, and we therefore recommend training of future bronchoscopists by this method.
DOI: 10.6084/m9.figshare.27255201
title: Supplementary Material for: “External Beam Radiotherapy for Malignant Central Airway Obstruction in a Remote Rural Patient: A Case Study”

description: Introduction:
Malignant central airway obstruction (MCAO) is a challenging therapeutic scenario, caused by tumour burden which limits airflow within the large airways. Squamous Cell Carcinoma (SCC) of the lung accounts for 50% of MCAO seen in the setting of Non-Small Cell Lung Cancer. 
Here we present the challenging case of a 63-year-old Indigenous Australian Female rom a remote rural community with background history of metastatic squamous cell carcinoma of presumed pulmonary origin, who presented with a 1-week history of dyspnoea, stridor, and hoarse voice. 
Case Presentation:
A CT chest and neck demonstrated a superior mediastinal mass compressing the trachea to a narrowest diameter of 3 mm. The patient was stabilised in her local health centre, then transferred to our tertiary care facility for further evaluation and management. 
This stenotic lesion was not amenable to bronchoscopic or surgical intervention but was instead treated successfully with a short course of external beam radiotherapy, to total dose of 25Gy delivered over 10 fractions. The patient had almost complete resolution of respiratory symptoms with no significant radiotherapy related toxicity.
Conclusion:
Here we discuss a challenging case of MCAO in a remote rural Australian patient and demonstrate the utility of external beam radiotherapy in this setting. We also discuss aspects of cancer related healthcare disparities which exist for Indigenous Australians. In doing so we wish to highlight the need for improved cancer healthcare for such communities.
DOI: 10.6084/m9.figshare.27255225
title: Supplementary Material for: Different patterns of platelet count fluctuation in response to various anti-cancer chemotherapies among patient with bladder cancer

description: Introduction: In general, platelet counts fluctuate in cancer patients receiving anti-cancer therapy. It may include thrombocytopenia caused by bone marrow suppression due to cytotoxic anticancer agents and thrombocytosis due to rebound during recovery. This should not be the case in the case of administration of immune checkpoint inhibitors, given their mechanism of action.
Case Presentation: However, we have experienced a case of thrombocytosis in a patient treated with an immune checkpoint inhibitor. We present a platelet count pattern in patient with bladder cancer underwent Gemcitabine and Cisplatin (GC) therapy and pembrolizumab monotherapy.
 Conclusion: This case underscores the need for a diverse perspective on platelet behaviour in clinical settings.
DOI: 10.6084/m9.figshare.27635292
title: Supplementary Material for: Assessment of coronary microvascular dysfunction by angiography‐based index of microcirculatory resistance: an indirect meta-analysis

description: Introduction: There is a lack of consensus on diagnosing coronary microvascular dysfunction (CMD) using the angiography-based index of microcirculatory resistance (Angio-IMR) due to the absence of evidence. This study aims to explore the efficacy of Angio-IMR in diagnosing CMD.
Methods: A systematic search was conducted in PubMed, Embase, Scopus, and Cochrane Library for studies primarily focusing on Angio-IMR diagnosing CMD, using IMR as the gold standard. The primary results were pooled sensitivity, specificity, and the area under curve (AUC).
Results: A total of 15 studies involving 2202 individuals and 2330 vessels were included in our study, Angio-IMR demonstrated high performance in predicting IMR with overall pooled sensitivity and specificity of 0.84 (95% confidence interval (CI): 0.81 to 0.87) and 0.87 (95%CI: 0.83 to 0.99), respectively, and AUC=0.91 (95%CI: 0.89 to 0.94). This indicates that Angio-IMR has good diagnostic characteristics. Subgroup analysis by indirect meta-analysis showed higher sensitivity in the rest state. However, there is no significant difference in sensitivity and specificity between the hyperemic and rest states when using the AccuIMR system. Furthermore, sensitivity and specificity were more pronounced in the group without coronary pressure monitoring compared to the group with monitoring. 
Conclusion: Angio-IMR is an alternative tool to identify CMD.
DOI: 10.6084/m9.figshare.27635331
title: Supplementary Material for: The potential of ESCO2 as a prognostic and immunotherapeutic marker of pan-cancer and its role in anti-PD1 treatment of bladder cancer

description: Background
Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), a member of the EFO2 family, is implicated in the pathogenesis and progression of various cancers. However, there has been limited comprehensive pan-cancer analysis conducted on ESCO2 thus far.
Methods
Publicly available databases, such as the UCSC Xena database, were utilized to examine differential expression patterns across various cancer types. In addition, variations in expression levels were investigated across distinct clinical stages. Univariate Cox regression and Kaplan-Meier survival analyses were conducted to evaluate the impact on overall survival (OS), disease-specific survival (DSS), disease-free interval (DFI), and progression-free interval (PFI) at a pan-cancer level. The correlation between ESCO2 expression and immune cell infiltration was examined to gain insight into the tumor microenvironment in different cancers. The results of the bioinformatic analysis were validated using immunotherapy clinical trials and pathological specimens. CCK-8 and transwell assay experiments were performed to investigate the biological function of ESCO2.
Results
ESCO2 expression was found to be up-regulated in most cancers, with a correlation to TNM stages. Prognostic analysis indicated that overexpression of ESCO2 was associated with poor prognosis in various cancers. Furthermore, the correlation between ESCO2 expression and immune cell infiltration suggested its potential as a predictor for immunotherapy efficacy. Notably, ESCO2 expression showed positive associations with immunoinhibitor, immnostimulator, MHC molecule, chemokine receptor, tumor mutation burden (TMB) and microsatellite instability (MSI) levels in bladder cancer (BLCA). The validation cohort for immunotherapy corroborated these findings and substantiated that ESCO2 could function as an autonomous prognostic biomarker and a promising target for cancer treatment via immunotherapy. In addition, in vitro experiments confirmed the role of ESCO2 in influcing the proliferation, invasion and migration of BLCA cells.
Conclusion
ESCO2 participates in regulating the immune infiltration and affecting the prognosis of patients in many cancers, especially in BLCA. ESCO2 may serve as a prognostic and immunotherapy biomarker in future treatment of human cancer.
DOI: 10.6084/m9.figshare.27635526
title: Supplementary Material for: A Programmatic Approach to En Bloc Transurethral Enucleation of the Prostate with Bipolar System (TUEB): A Single-Center Retrospective Report

description: Introduction: This study presents a systematic approach for en bloc transurethral enucleation of the prostate utilizing a bipolar system (TUEB), evaluating its effectiveness and safety. Furthermore, the research aims to pinpoint risk factors contributing to early stress urinary incontinence (SUI) after undergoing en bloc TUEB.
Methods: The en bloc TUEB procedure is visually demonstrated through images and videos. A retrospective analysis was conducted based on the data of 88 patients diagnosed with benign prostatic hyperplasia (BPH) who underwent en bloc TUEB between January 2018 and April 2023. Detailed perioperative and follow-up clinical data were collected and analyzed. Patients were categorized based on the occurrence of SUI, and their clinical characteristics were analyzed.
Results: The mean surgical duration was 113.1 ± 50.0 minutes, resulting in an excised prostate gland weighing 58.0 ± 34.3 g and a hemoglobin drop of 14.3 ± 11.2 g/L. The average enucleation rate was 79.00 ± 11.01 %, enucleation efficiency was 0.54 ± 0.26 g/min and prostate specific antigen (PSA) reduction rate was 42.08 ± 22.85 %. There were no major complications during operation. Twenty-three patients (26.13%) developed early SUI after catheter removal, and 74% of them were in remission within 1 month. Importantly, no cases of persistent SUI were observed. Lower urinary tract symptoms (LUTS) duration was significantly different between patients with and without post-operative SUI. Residual urine volume, International Prostate Symptom Score (IPSS) and Quality of Life (QoL) score were significantly improved in BPH patients after surgery (P &lt; 0.05). Twelve months after surgery, only 2 patients (2.27%) had urethral stricture, although it recovered after transurethral dilation.
Conclusions: En bloc TUEB is proven to be effective, practical, efficient and safe with minimal complications. This procedure could be standardized and widely adopted. LUTS duration can predict the risk of early SUI.
DOI: 10.6084/m9.figshare.27635967
title: Supplementary Material for: Omentin increases glucose uptake, but not insulin sensitivity in human myotubes dependent on extracellular lactotransferrin

description: Introduction: Omentin (intelectin-1) is an adipokine produced by the stromal vascular fraction of visceral adipose tissue and has been positively associated with insulin sensitivity. The underlying mechanism of action, however, is largely unknown. It has been described that omentin may increase insulin sensitivity and glucose uptake of adipocytes, but effects on other insulin-sensitive tissues such as skeletal muscle are unexplored. We therefore investigated effects of omentin on insulin sensitivity and metabolism of primary human myotubes. 
Methods: Primary human myotubes were treated with 0.5 or 2 µg/mL omentin and subsequently protein detection, glucose uptake assay, lactate assay and lipidomics analysis were performed.
Results: Omentin did not affect skeletal muscle insulin signaling, as assessed by basal and insulin-stimulated phosphorylation of IRS1 and AKT. Omentin increased basal, but not insulin-stimulated glucose uptake. While increased glycolytic activity was confirmed by elevated lactate release after omentin treatment, effects on cellular lipid composition were limited to an increase in total triacylglycerol concentration. Increased glucose uptake by omentin was counteracted by addition of extracellular lactotransferrin, which can bind to omentin.
Conclusions: Overall, increased basal glucose uptake in skeletal muscle cells suggests differential effects of omentin on insulin-sensitive tissues. Moreover, an involvement of lactotransferrin in omentin’s mechanism of action may partially explain contradictory results of epidemiological studies on the role of omentin in different diseases.
DOI: 10.6084/m9.figshare.27641427
title: Supplementary Material for: Sex-disaggregated analysis of central venous catheter-related bloodstream infections in patients with cancer

description: Introduction: Men are generally more susceptible to bacterial infections than women. Central venous catheters (CVCs), often used to administer systemic treatment in patients with cancer, are an important source of infection. However, little is known about sex-specific differences of CVC-related bloodstream infections (CRBSIs) in patients with cancer. This study aimed to compare CRBSIs in men vs. women in a large cohort of patients with cancer. Methods: Data were derived from the SECRECY registry including non-selected patients with centrally inserted non-tunneled internal jugular or subclavian vein CVCs in 10 hematology and oncology sites in Germany. Only CRBSIs classified as definite CRBSI (dCRBSI) or probable CRBSI were included, and the combination of both was summarized as dpCRBSI. CVCs were matched 1:1 for underlying disease, anatomic site of CVC insertion, type of CVC dressing, antimicrobial coated CVC, complicated CVC insertion and CVC in situ time by propensity score matching (PSM). Endpoints were CRBSI rates and incidences in CVCs inserted in men vs. women. Results: A total of 5075 CVCs registered from March 2013 to March 2024 were included in the analysis, of which 3024 comprises the PSM cohort. 1512 (50.0%) CVCs were inserted in men. Underlying diseases mainly were hematological malignancies (96.4%). While there was no statistically significant difference between men and women in the dCRBSI rate (5.4% vs. 4.1%; p=0.12) and the dCRBSI incidence (3.8 vs. 2.9/1000 CVC days; p=0.11), the rate of dpCRBSI (9.9% vs. 6.7%; p=0.002) and the dpCRBSI incidence (7.0 vs. 4.7/1000 CVC days; p=0.002) were significantly higher in men vs. women. The proportion of coagulase-negative staphylococci as causative agent of both dCRBSI and dpCRBSI was higher in men than in women (58.8% vs. 41.2%; p=0.07, and 61.5% vs. 38.5%; p=0.002, respectively). A multivariable regression revealed neutropenia as an independent risk factor for dCRBSI and male sex as risk factor for dCRBSI and dpCRBSI. Conclusion: In patients with hematological malignancies, men have a higher risk of CRBSI than women. This finding may be attributed to the high number of jugular vein inserted CVCs which in men may be associated with higher rates of skin colonization than in women. Special preventive measures such as earlier removal of CVCs in men may be studied in future.