cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14278767.v1
title: Use of lung ultrasound in neonates during the COVID-19 pandemic

description: Abstract In the current pandemic, caused by infection with severe acute respiratory syndrome coronavirus 2, ultrasound has played a fundamental role in patients who develop the resulting disease, designated coronavirus disease 2019 (COVID-19). In this study we present ultrasound images of the lungs of neonates with a suspected or confirmed diagnosis of COVID-19, distinguishing between the changes related to COVID-19 and those unrelated to the disease. Ultrasound examinations were performed by a pediatric sonographer. A total of 27 neonates were evaluated. Among those who presented no respiratory symptoms, some tested negative for COVID-19 and others tested positive. All of those who were pulmonary symptomatic, negative for COVID-19 presented transient tachypnea of the newborn and respiratory distress syndrome. Lung ultrasound images obtained in COVID-19-negative neonates showed, in some cases, a normal pattern (with A lines, few B lines, a thin, linear pleural line, and no pleural effusion), whereas in others showed coalescent B lines and areas of opacity. In two of the COVID-19-positive neonates, lung ultrasound examination showed several coalescent B lines, pleural thickening, and areas of opacity. Lung ultrasound in the neonatal period appears to be applicable within the context of the current pandemic, allowing efficient evaluation of COVID-19-related changes in neonates, as well as of pathologies inherent to the neonatal period.
DOI: 10.6084/m9.figshare.14278772
title: Chest computed tomography in COVID-19 pneumonia: a retrospective study of 155 patients at a university hospital in Rio de Janeiro, Brazil

description: Abstract Objective: To define diagnostic criteria for coronavirus disease 2019 (COVID-19) on computed tomography (CT); to study the correlation between CT and polymerase chain reaction (PCR) testing for infection with severe acute respiratory syndrome coronavirus 2; and to determine whether the extent of parenchymal involvement and the need for mechanical ventilation are associated with the CT findings and clinical characteristics of patients with COVID-19. Materials and Methods: This was a retrospective study of 155 patients with COVID-19 treated between March and May 2020. We attempted to determine whether the CT findings correlated with age and clinical variables, as well as whether the need for mechanical ventilation correlated with the extent of the pulmonary involvement. Results: On average, the patients with COVID-19 were older than were those without (mean age, 54.8 years vs. 45.5 years; p = 0.031). The most common CT finding (seen in 88.6%) was ground-glass opacity, which correlated significantly with a diagnosis of COVID-19 (p = 0.0001). The CT findings that correlated most strongly with the need for mechanical ventilation were parenchymal bands (p = 0.013), bronchial ectasia (p = 0.046), and peribronchovascular consolidations (p = 0.012). The presence of one or more comorbidities correlated significantly with more extensive parenchymal involvement (p = 0.023). For the diagnosis of COVID-19, CT had a sensitivity of 84.3%, a specificity of 36.7%, and an accuracy of 73.5% (p = 0.012 vs. PCR). Conclusion: The patterns of CT findings are useful for the diagnosis of COVID-19 and the evaluation of disease severity criteria. The presence of any comorbidity is associated with greater severity of COVID-19.
DOI: 10.6084/m9.figshare.14278772.v1
title: Chest computed tomography in COVID-19 pneumonia: a retrospective study of 155 patients at a university hospital in Rio de Janeiro, Brazil

description: Abstract Objective: To define diagnostic criteria for coronavirus disease 2019 (COVID-19) on computed tomography (CT); to study the correlation between CT and polymerase chain reaction (PCR) testing for infection with severe acute respiratory syndrome coronavirus 2; and to determine whether the extent of parenchymal involvement and the need for mechanical ventilation are associated with the CT findings and clinical characteristics of patients with COVID-19. Materials and Methods: This was a retrospective study of 155 patients with COVID-19 treated between March and May 2020. We attempted to determine whether the CT findings correlated with age and clinical variables, as well as whether the need for mechanical ventilation correlated with the extent of the pulmonary involvement. Results: On average, the patients with COVID-19 were older than were those without (mean age, 54.8 years vs. 45.5 years; p = 0.031). The most common CT finding (seen in 88.6%) was ground-glass opacity, which correlated significantly with a diagnosis of COVID-19 (p = 0.0001). The CT findings that correlated most strongly with the need for mechanical ventilation were parenchymal bands (p = 0.013), bronchial ectasia (p = 0.046), and peribronchovascular consolidations (p = 0.012). The presence of one or more comorbidities correlated significantly with more extensive parenchymal involvement (p = 0.023). For the diagnosis of COVID-19, CT had a sensitivity of 84.3%, a specificity of 36.7%, and an accuracy of 73.5% (p = 0.012 vs. PCR). Conclusion: The patterns of CT findings are useful for the diagnosis of COVID-19 and the evaluation of disease severity criteria. The presence of any comorbidity is associated with greater severity of COVID-19.
DOI: 10.6084/m9.figshare.14278774.v1
title: Tomographic findings in bronchial atresia

description: Abstract Objective: To evaluate computed tomography (CT) findings in 23 patients with bronchial atresia. Materials and Methods: The CT images were reviewed by two radiologists who reached decisions by consensus. We included only patients who presented with abnormalities on CT and in whom the diagnosis had been confirmed by pathological examination of the surgical specimen (if the lesion was resected). The CT scans were assessed in order to identify the main findings and to map the distribution of the lesions (i.e., to determine whether the pulmonary involvement was unilateral or bilateral). Results: The main CT finding was the combination of bronchocele and hyperinflation of the distal lung. That combination was observed in all of the patients. The lesions were unilateral in all 23 cases, being seen predominantly in the left upper lobe, followed by the right lower lobe, right upper lobe, middle lobe, and left lower lobe. Conclusion: The diagnosis of bronchial atresia can be reliably made on the basis of a finding of bronchocele accompanied by hyperinflation of the adjacent lung parenchyma.
DOI: 10.6084/m9.figshare.14277410.v2
title: tmp

description: The publication of this study on AG has important reference significance for researchers studying the genetic mechanism of fat content.
DOI: 10.6084/m9.figshare.14278775
title: Biliary involvement in liver metastases: long-term experience with biliary biopsy from a single center

description: Abstract Objective: To investigate long-term results of biliary biopsy performed with transluminal forceps in the setting of metastatic biliary involvement. Materials and Methods: Between September 2014 and June 2019, 25 patients-18 males (72%)-with a mean age of 65 ± 15 years, underwent 26 biliary biopsy procedures with a dedicated forceps system. All patients presented with obstructive jaundice that was suspected of being malignant and underwent pre-procedural magnetic resonance cholangiopancreatography. The biopsies were performed during percutaneous placement of an internal-external biliary drainage catheter, under fluoroscopic guidance. Results: The technical success rate was 96% (corresponding to 25 of the 26 procedures). The histological diagnosis was inflammatory biliary stricture in five cases, pancreatic adenocarcinoma in six, liver metastases from colorectal cancer in eight, and hepatocellular carcinoma in three, the biliary mucosa being categorized as normal in three cases. In one case, the sample was considered insufficient and the procedure was successfully repeated, after which a diagnosis of pancreatic adenocarcinoma was made. Over a follow-up period of 6-48 months, there were five false-negative results: two findings of inflammatory biliary stricture were later identified as liver metastases from breast and gastric cancer, respectively; and all three patients in which the biliary mucosa was categorized as normal were subsequently diagnosed with metastatic hilar lymph nodes. The procedure was found to have a sensitivity of 77%, a specificity of 100%, and an overall accuracy of 80%. The complication rate was 11.5% (mild, transient hemobilia occurring in three cases). Conclusion: Percutaneous transluminal forceps biopsy is a safe, effective, minimally invasive procedure for histological characterization in patients presenting with obstructive jaundice due to a non-primary biliary tumor.
DOI: 10.6084/m9.figshare.14278775.v1
title: Biliary involvement in liver metastases: long-term experience with biliary biopsy from a single center

description: Abstract Objective: To investigate long-term results of biliary biopsy performed with transluminal forceps in the setting of metastatic biliary involvement. Materials and Methods: Between September 2014 and June 2019, 25 patients-18 males (72%)-with a mean age of 65 ± 15 years, underwent 26 biliary biopsy procedures with a dedicated forceps system. All patients presented with obstructive jaundice that was suspected of being malignant and underwent pre-procedural magnetic resonance cholangiopancreatography. The biopsies were performed during percutaneous placement of an internal-external biliary drainage catheter, under fluoroscopic guidance. Results: The technical success rate was 96% (corresponding to 25 of the 26 procedures). The histological diagnosis was inflammatory biliary stricture in five cases, pancreatic adenocarcinoma in six, liver metastases from colorectal cancer in eight, and hepatocellular carcinoma in three, the biliary mucosa being categorized as normal in three cases. In one case, the sample was considered insufficient and the procedure was successfully repeated, after which a diagnosis of pancreatic adenocarcinoma was made. Over a follow-up period of 6-48 months, there were five false-negative results: two findings of inflammatory biliary stricture were later identified as liver metastases from breast and gastric cancer, respectively; and all three patients in which the biliary mucosa was categorized as normal were subsequently diagnosed with metastatic hilar lymph nodes. The procedure was found to have a sensitivity of 77%, a specificity of 100%, and an overall accuracy of 80%. The complication rate was 11.5% (mild, transient hemobilia occurring in three cases). Conclusion: Percutaneous transluminal forceps biopsy is a safe, effective, minimally invasive procedure for histological characterization in patients presenting with obstructive jaundice due to a non-primary biliary tumor.
DOI: 10.6084/m9.figshare.14278778.v1
title: Proposal for computer-aided diagnosis based on ultrasound images of the kidney: is it possible to compare shades of gray among such images?

description: Abstract Objective: To compare ultrasound images of the kidney obtained, randomly or in a controlled manner (standardizing the physical aspects of the ultrasound system), by various professionals and with different devices. Materials and Methods: We evaluated a total of 919 images of kidneys, obtained by five professionals using two types of ultrasound systems, in 24 patients. The images were categorized into four types, by how they were acquired and processed. We compared the gray-scale median and different gray-scale ranges representative of virtual histological tissues. Results: There were statistically significant differences among the five professionals, regardless of the type of ultrasound system employed, in terms of the gray-scale medians for the images obtained (p &lt; 2.2e-16). Analyzing the four categories of images-a totally random image (without any standardization); a standardized image (with fixed values for gain, time gain control, and dynamic range); a normalized version of the random image; and a normalized version of the standardized image-we determined that the random image, even after normalization, differed quite significantly among the professionals (p = 0.006098). The analysis of the normalized version of the standardized image did not differ significantly among the professionals (p = 0.7319). Conclusion: Our findings indicate that a gray-scale analysis of ultrasound images of the kidney performs better when the image acquisition process is standardized and the images undergo a process of normalization.
DOI: 10.6084/m9.figshare.11997189
title: DEVELOPMENT OF ANALYTICAL METHODOLOGIES FOR THE DETERMINATION OF CHLORPYRYPHES IN AQUEOUS SAMPLES EMPLOYING THE DISPERSIVE LIQUID MICROEXTRACTION FOLLOWED BY HPLC-UV

description: The miniaturized extraction techniques use less aggressive methods to the environment, since they generate less waste and spend a minimum of organic solvents, besides having a good selectivity and specificity in the extractions. In this context, liquid-liquid dispersive microextraction (DLLME) has been highlighting. Thus, the present article describes an optimization of the DLLME using low environmental impact extractor solvent to determine the chlorpyrifos insecticide in water. The analytical curves presented values for the correlation coefficient (r) higher than 0.999. The limits of detection and quantification were 0.24 and 0.80 µg L-1, respectively. There were recoveries between 93 and 97 %, with relative standard deviation (RSD) varying between 1.00 and 3.61%. The developed methods presented accurate and reliable results, are simple and safe, characteristics important for the implementation of a methodology as a routine analysis, and were applied in the determination of chlorpyrifos in water samples from five points along the Rio Dourados, near the city of Fátima do Sul.
DOI: 10.6084/m9.figshare.14277410.v1
title: tmp

description: The publication of this study on AG has important reference significance for researchers studying the genetic mechanism of fat content.
DOI: 10.6084/m9.figshare.14278777.v1
title: Direct and virtual measurements of abdominal aortic aneurysms: three-dimensional printed models

description: Abstract Objective: To validate the use of a three-dimensional printing system for metric and volumetric analysis of the segments of an abdominal aortic aneurysm (AAA). Materials and Methods: In patients scheduled to undergo endovascular AAA repair, the computed tomography angiography (CTA) measurements obtained during the preoperative assessment of the patients were compared with those obtained by computed tomography of individualized three-dimensional biomodels. Results: The volumetric assessment showed a discrepancy of 3-12%, and the difference between the areas was 10-16%. Conclusion: Computed tomography measurements of 3D-printed biomodels of AAAs appear to be comparable to those of threedimensional CTA measurements of the same AAAs, in terms of the metric and volumetric dimensions.
DOI: 10.6084/m9.figshare.14278778
title: Proposal for computer-aided diagnosis based on ultrasound images of the kidney: is it possible to compare shades of gray among such images?

description: Abstract Objective: To compare ultrasound images of the kidney obtained, randomly or in a controlled manner (standardizing the physical aspects of the ultrasound system), by various professionals and with different devices. Materials and Methods: We evaluated a total of 919 images of kidneys, obtained by five professionals using two types of ultrasound systems, in 24 patients. The images were categorized into four types, by how they were acquired and processed. We compared the gray-scale median and different gray-scale ranges representative of virtual histological tissues. Results: There were statistically significant differences among the five professionals, regardless of the type of ultrasound system employed, in terms of the gray-scale medians for the images obtained (p &lt; 2.2e-16). Analyzing the four categories of images-a totally random image (without any standardization); a standardized image (with fixed values for gain, time gain control, and dynamic range); a normalized version of the random image; and a normalized version of the standardized image-we determined that the random image, even after normalization, differed quite significantly among the professionals (p = 0.006098). The analysis of the normalized version of the standardized image did not differ significantly among the professionals (p = 0.7319). Conclusion: Our findings indicate that a gray-scale analysis of ultrasound images of the kidney performs better when the image acquisition process is standardized and the images undergo a process of normalization.
DOI: 10.6084/m9.figshare.11997177
title: MONITORING OF ADULTERANTS IN CRAMBE METHYL BIODIESEL IN MIXTURES WITH DIESEL, USING FT-MIR AND MULTIVARIATE CONTROL CHARTS BASED ON NET ANALYTE SIGNAL

description: Adulterants in biodiesel/diesel blends modifies its physical and chemical properties. In this work, Fourier Transform Mid-Infrared spectrometry (FT-MIR) and multivariate control charts based on Net Analyte Signal (NAS) were used to monitor the quality of Crambe methyl biodiesel in relation to the biodiesel content and the presence of adulterants. The calibration model was constructed from the decomposition of the instrumental signals of the calibration samples into three vectors: NAS, interference and residual. From these vectors, three control charts were built: (i) NAS chart to monitor the analyte of interest (Crambe methyl biodiesel); (ii) Interference chart to monitor the data matrix (all components in diesel without the analyte of interest); and (iii) Residual chart to monitor any non-systematic variations. To validate the calibration model, other groups of B10, BX and B10 samples adulterated by direct addition of soybean oil and used fry oil in the range of 4.85-30.13% (v/v) were used. All samples prepared in-quality specifics were correctly classified as “in-quality control” samples, and other samples were correctly classified as “out-of-quality control” samples. Therefore, the methodology developed proved to be efficient in monitoring the quality of this fuel and it can be used by supervisory and quality control agencies.
DOI: 10.6084/m9.figshare.11997189.v1
title: DEVELOPMENT OF ANALYTICAL METHODOLOGIES FOR THE DETERMINATION OF CHLORPYRYPHES IN AQUEOUS SAMPLES EMPLOYING THE DISPERSIVE LIQUID MICROEXTRACTION FOLLOWED BY HPLC-UV

description: The miniaturized extraction techniques use less aggressive methods to the environment, since they generate less waste and spend a minimum of organic solvents, besides having a good selectivity and specificity in the extractions. In this context, liquid-liquid dispersive microextraction (DLLME) has been highlighting. Thus, the present article describes an optimization of the DLLME using low environmental impact extractor solvent to determine the chlorpyrifos insecticide in water. The analytical curves presented values for the correlation coefficient (r) higher than 0.999. The limits of detection and quantification were 0.24 and 0.80 µg L-1, respectively. There were recoveries between 93 and 97 %, with relative standard deviation (RSD) varying between 1.00 and 3.61%. The developed methods presented accurate and reliable results, are simple and safe, characteristics important for the implementation of a methodology as a routine analysis, and were applied in the determination of chlorpyrifos in water samples from five points along the Rio Dourados, near the city of Fátima do Sul.
DOI: 10.6084/m9.figshare.14278777
title: Direct and virtual measurements of abdominal aortic aneurysms: three-dimensional printed models

description: Abstract Objective: To validate the use of a three-dimensional printing system for metric and volumetric analysis of the segments of an abdominal aortic aneurysm (AAA). Materials and Methods: In patients scheduled to undergo endovascular AAA repair, the computed tomography angiography (CTA) measurements obtained during the preoperative assessment of the patients were compared with those obtained by computed tomography of individualized three-dimensional biomodels. Results: The volumetric assessment showed a discrepancy of 3-12%, and the difference between the areas was 10-16%. Conclusion: Computed tomography measurements of 3D-printed biomodels of AAAs appear to be comparable to those of threedimensional CTA measurements of the same AAAs, in terms of the metric and volumetric dimensions.
DOI: 10.6084/m9.figshare.11997393
title: NANO-ENCAPSULATION OF Lippia origanoides KUNTH. ESSENTIAL OIL BY CHITOSAN-CAFFEIC ACID NANOGEL

description: In this study, a nanogel was developed from a natural polymer, chitosan, to be used in the Lippia origanoides essential oil encapsulation. The encapsulation process was used in order to improve the functional capacity of this essential oil as an antioxidant. To obtain the nanogel, the chitosan was modified with caffeic acid using EDC coupling agent. The obtained material was characterized by FTIR and TGA, revealing the formation of the chitosan-caffeic acid bond. The size, morphology and essential oil amount incorporated to the nanogel were investigated by DLS, SEM and gravimetric analysis, respectively. SEM and gravimetric analysis indicated that oil were efficiently trapped inside the CS-CA matrix, with encapsulation efficiency of 42 ± 2%. The EDL studies showed that the encapsulation of essential oil in the nanogel significantly affected your structure, with a average particle size of 417.26 ± 55.96. After essential oil incorporation into the CS-CA nanogel it was also observed a increase in its antioxidant capacity in terms of elimination of DPPH and ABTS radicals, and ferric reducing antioxidant power (FRAP). The successful development of this CS-CA nanogel loaded with L. origanoides essential oil will lead to a better applicability of this essential oil as an effective antioxidant.
DOI: 10.6084/m9.figshare.11997177.v1
title: MONITORING OF ADULTERANTS IN CRAMBE METHYL BIODIESEL IN MIXTURES WITH DIESEL, USING FT-MIR AND MULTIVARIATE CONTROL CHARTS BASED ON NET ANALYTE SIGNAL

description: Adulterants in biodiesel/diesel blends modifies its physical and chemical properties. In this work, Fourier Transform Mid-Infrared spectrometry (FT-MIR) and multivariate control charts based on Net Analyte Signal (NAS) were used to monitor the quality of Crambe methyl biodiesel in relation to the biodiesel content and the presence of adulterants. The calibration model was constructed from the decomposition of the instrumental signals of the calibration samples into three vectors: NAS, interference and residual. From these vectors, three control charts were built: (i) NAS chart to monitor the analyte of interest (Crambe methyl biodiesel); (ii) Interference chart to monitor the data matrix (all components in diesel without the analyte of interest); and (iii) Residual chart to monitor any non-systematic variations. To validate the calibration model, other groups of B10, BX and B10 samples adulterated by direct addition of soybean oil and used fry oil in the range of 4.85-30.13% (v/v) were used. All samples prepared in-quality specifics were correctly classified as “in-quality control” samples, and other samples were correctly classified as “out-of-quality control” samples. Therefore, the methodology developed proved to be efficient in monitoring the quality of this fuel and it can be used by supervisory and quality control agencies.