cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30901586.v1
title: Supplementary Material for: Validation of the efficacy and safety of targeted pulsed ablation of the bronchus with a novel navigated pulsed electric field ablation system

description: Background：Bronchial rheoplasty with non-thermal pulsed electric field (PEF) ablation has excellent developmental potential for the therapy of chronic bronchitis (CB) subtypes of chronic obstructive pulmonary disease (COPD). However, the volume of reported clinical studies is quite limited. Also, repeated and missed ablations are involved during the procedure, affecting the targeted therapy and PEF further development.
Objectives: Evaluating the feasibility, safety and efficacy of a novel navigated PEF ablation system in the therapy of CB, promoting the COPD therapeutic field toward a new stage of greater precision and efficiency.
Methods：First, real-time navigated bronchial rheoplasty were performed in 18 live pigs by a novel navigated PEF ablation system (variable-diameter navigated PEF ablation catheter with a length of 1.4 m and an outer diameter of 1.5 mm) with 84 d of follow-up. Subsequently, bilateral bronchial rheoplasty was conducted in 4 patients with CB using this system. Changes in CAT scores, mMRC scores, CT tests and lung function were explored during the 6-months follow-up. The feasibility, safety and efficacy of the technique were further evaluated.
Results：Real-time navigated bronchial rheoplasty was performed successfully in 18 live pigs without any serious complications. Pathologic results showed complete recovery of mild tissue inflammation during follow-up from 4 h to 28 d. In the clinical trial, a total of 8 PEFs were performed in 4 patients with CB subtype COPD, achieving a technical success rate of 100%. There were no device or procedure-related serious adverse events within 6 months.
Conclusions: Precision-targeted ablation of patients with CB by a novel navigated PEF ablation system is a safe, feasible, and effective approach.
DOI: 10.6084/m9.figshare.30901589
title: Supplementary Material for: Developmental changes in the expression of lysophosphatidic acid receptor 4 in the mouse brain

description: Introduction: Lysophosphatidic acid (LPA) is a bioactive phospholipid that mediates a variety of biological actions through binding to G protein-coupled receptors (GPCRs) known as LPA receptors (LPARs). In mammals, six LPAR subtypes (LPAR1–6) have been identified. This study aims to determine the expression of LPAR4 in the developing mouse brain. Methods: Brains samples were prepared from mice in various stages of development and biochemical and immunohistochemical analyses were conducted using anti-LPAR4. Results: Western blot analysis detected two LPAR4-immunoreactive species at ~50 kDa and ~42 kDa from embryonic day 16.5 (E16.5). The ~50 kDa molecule increased during development, reaching a peak at postnatal day 3 (P3), and then gradually decreased through P22. In contrast, the ~42 kDa molecule continued to increase up to P22. Immunohistochemical analyses demonstrated strong LPAR4 expression in neural cells in the intermediate zone and cortical plate of the E15.5 cerebral cortex, whereas neural progenitors in the ventricular and subventricular zones exhibited weaker expression. At P15, fiber-like staining resembling the apical dendrites of cortical neurons and hippocampal pyramidal cells was also observed. Conclusion: This study demonstrated dynamic, spatiotemporal changes of LPAR4 expression in the brain from embryonic to postnatal stages. These findings support a potential role for LPAR4 in neural development.
DOI: 10.6084/m9.figshare.30901589.v1
title: Supplementary Material for: Developmental changes in the expression of lysophosphatidic acid receptor 4 in the mouse brain

description: Introduction: Lysophosphatidic acid (LPA) is a bioactive phospholipid that mediates a variety of biological actions through binding to G protein-coupled receptors (GPCRs) known as LPA receptors (LPARs). In mammals, six LPAR subtypes (LPAR1–6) have been identified. This study aims to determine the expression of LPAR4 in the developing mouse brain. Methods: Brains samples were prepared from mice in various stages of development and biochemical and immunohistochemical analyses were conducted using anti-LPAR4. Results: Western blot analysis detected two LPAR4-immunoreactive species at ~50 kDa and ~42 kDa from embryonic day 16.5 (E16.5). The ~50 kDa molecule increased during development, reaching a peak at postnatal day 3 (P3), and then gradually decreased through P22. In contrast, the ~42 kDa molecule continued to increase up to P22. Immunohistochemical analyses demonstrated strong LPAR4 expression in neural cells in the intermediate zone and cortical plate of the E15.5 cerebral cortex, whereas neural progenitors in the ventricular and subventricular zones exhibited weaker expression. At P15, fiber-like staining resembling the apical dendrites of cortical neurons and hippocampal pyramidal cells was also observed. Conclusion: This study demonstrated dynamic, spatiotemporal changes of LPAR4 expression in the brain from embryonic to postnatal stages. These findings support a potential role for LPAR4 in neural development.
DOI: 10.6084/m9.figshare.30901592
title: Supplementary Material for: Breaking the Intergenerational Cycle of Abuse – a Randomized Controlled Prevention Trial in Parents with Serious Mental Illness

description: Introduction: Although children of parents with mental illness (MI) are at increased risk of adverse childhood experiences and parental maltreatment, prevention trials targeting parents with MI are scarce. In addition, meta-analyses highlight significant methodological shortcomings in the current research. Trial design: To investigate real-world efficacy of a 12-hours mentalization-based parenting counselling program (MB-PC) compared to a psychoeducation workshop (SCC+) as supplements to standard clinical care (SCC). Methods: This large-scale, cluster-randomized, open-label (partially observer-blind), active-controlled bicentre superiority trial was conducted at German psychiatric hospitals. It included 252 patients undergoing psychiatric treatment for various serious MIs. MB-PC subsumed five individual sessions including video feedback, five group sessions that guided parents to better understand and respond to their child’s mental states, and two sessions of social counselling, all provided by an interprofessional hospital team of non-psychothera¬pists. Results: Patients in the MB-PC arm reported improved parenting practices – measured by the Alabama Parenting Questionnaire (APQ) total score as primary outcome – at post-intervention compared to those from the SSC+ arm (effect size (ES) = 0.43, 95% CI (0.13, 0.73), p=0.004), but group difference decreased at 3-months follow-up (ES = 0.25, 95% CI (-0.04, 0.53), p=0.085). All secondary outcomes were in favour of the MB-PC intervention, such as parental stress, child abuse potential, and child emotional well-being. Conclusion: Implementing a mentalisation-based parenting programme in routine psychiatric hospital care may represent an important step forward in reducing the risk of child maltreatment and neglect among offspring of parents affected by severe mental disorders.
DOI: 10.6084/m9.figshare.30901592.v1
title: Supplementary Material for: Breaking the Intergenerational Cycle of Abuse – a Randomized Controlled Prevention Trial in Parents with Serious Mental Illness

description: Introduction: Although children of parents with mental illness (MI) are at increased risk of adverse childhood experiences and parental maltreatment, prevention trials targeting parents with MI are scarce. In addition, meta-analyses highlight significant methodological shortcomings in the current research. Trial design: To investigate real-world efficacy of a 12-hours mentalization-based parenting counselling program (MB-PC) compared to a psychoeducation workshop (SCC+) as supplements to standard clinical care (SCC). Methods: This large-scale, cluster-randomized, open-label (partially observer-blind), active-controlled bicentre superiority trial was conducted at German psychiatric hospitals. It included 252 patients undergoing psychiatric treatment for various serious MIs. MB-PC subsumed five individual sessions including video feedback, five group sessions that guided parents to better understand and respond to their child’s mental states, and two sessions of social counselling, all provided by an interprofessional hospital team of non-psychothera¬pists. Results: Patients in the MB-PC arm reported improved parenting practices – measured by the Alabama Parenting Questionnaire (APQ) total score as primary outcome – at post-intervention compared to those from the SSC+ arm (effect size (ES) = 0.43, 95% CI (0.13, 0.73), p=0.004), but group difference decreased at 3-months follow-up (ES = 0.25, 95% CI (-0.04, 0.53), p=0.085). All secondary outcomes were in favour of the MB-PC intervention, such as parental stress, child abuse potential, and child emotional well-being. Conclusion: Implementing a mentalisation-based parenting programme in routine psychiatric hospital care may represent an important step forward in reducing the risk of child maltreatment and neglect among offspring of parents affected by severe mental disorders.
DOI: 10.6084/m9.figshare.30901595
title: Supplementary Material for: A Case of FAM111A-Associated Kenny–Caffey Syndrome Type 2 With New Clinical Features: Microtia, Lacunar Skull Appearance, and Arnold–Chiari Malformation

description: Introduction: Kenny–Caffey syndrome type 2 (KCS2, #OMIM127000) is an extremely rare skeletal dysplasia characterized by characteristic facial features, relative macrocephaly, short stature, hypoparathyroidism, hypocalcemia, cortical thickening of tubular bones, and medullary stenosis. It is caused by the Family with Sequence Similarity 111 Member A (FAM111A) gene. Case Presentation: Herein, we report a 7-year-old boy with microphthalmia, delayed anterior fontanelle closure, short stature, hypoparathyroidism, hypocalcemia, cortical thickening of tubular bones, and medullary stenosis. The presented patient had microcephaly, maculopathy, and craniosynostosis as rare distinct features. Microtia, lacunar skull appearance and Arnold-Chiari malformation were present only in the reported patient. A diagnosis of KCS2 was considered with the clinical and radiological findings. Whole exome sequencing identified a heterozygous pathogenic hotspot variant, c.1706G&gt;A p.Arg569His (NM_001312909.2), in the FAM111A gene. Conclusion: Accurate diagnosis plays a critical role in enhancing clinical awareness, improving patient management, and offering appropriate genetic counseling for affected families.
DOI: 10.6084/m9.figshare.30901595.v1
title: Supplementary Material for: A Case of FAM111A-Associated Kenny–Caffey Syndrome Type 2 With New Clinical Features: Microtia, Lacunar Skull Appearance, and Arnold–Chiari Malformation

description: Introduction: Kenny–Caffey syndrome type 2 (KCS2, #OMIM127000) is an extremely rare skeletal dysplasia characterized by characteristic facial features, relative macrocephaly, short stature, hypoparathyroidism, hypocalcemia, cortical thickening of tubular bones, and medullary stenosis. It is caused by the Family with Sequence Similarity 111 Member A (FAM111A) gene. Case Presentation: Herein, we report a 7-year-old boy with microphthalmia, delayed anterior fontanelle closure, short stature, hypoparathyroidism, hypocalcemia, cortical thickening of tubular bones, and medullary stenosis. The presented patient had microcephaly, maculopathy, and craniosynostosis as rare distinct features. Microtia, lacunar skull appearance and Arnold-Chiari malformation were present only in the reported patient. A diagnosis of KCS2 was considered with the clinical and radiological findings. Whole exome sequencing identified a heterozygous pathogenic hotspot variant, c.1706G&gt;A p.Arg569His (NM_001312909.2), in the FAM111A gene. Conclusion: Accurate diagnosis plays a critical role in enhancing clinical awareness, improving patient management, and offering appropriate genetic counseling for affected families.
DOI: 10.6084/m9.figshare.30901598
title: Supplementary Material for: Title: Hans-based cell of origin is not of prognostic significance in DLBCL patients; Retrospective single center study conducted in 326 RCHOP treated patients

description: Background: Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive lymphoma with dismal outcome after disease progression. Individual risk assessment can stratify patients into different treatment strategies.
Methods: We retrospectively collected data from 326 DLBCL patients treated in a single center with RCHOP from 01/2000 to 06/2023. Immunohistochemistry by Hans algorithm was used to classify patients according to cell of origin (COO). The Kaplan-Meier estimator of survival and Cox regression analysis were used.
Results: Time to progression (TTP) and overall survival (OS) were not different according to COO. Univariate analysis reveals international prognostic index (IPI), b2-microgloboulin ≥ 3,5 mg/L, bulky disease and abnormal LDH, but not Han’s defined COO, as the strongest predictors for progression. IPI score in multivariate analysis was the only prognostic factor for OS and together with high b2-microglobulin levels were independently prognostic factors for TTP. Accordingly, b2-microglobulin ≥ 3,5 mg/L was an independent prognostic factor for progression both in GC (HR 0,249 [(95% CI: 0,087-0,649), p=0,004] and non-GC DLBCL patients [HR 0,380 (95% CI: 0,177-0,813), p=0,011]. 
Conclusions: Cell of origin according to Hans Index is not a significant prognostic factor for DLBCL patients but b2 microglobulin ≥ 3,5 mg/L and IPI 2-5 in both GC and non-GC patients can predict individually a higher risk for progression.
DOI: 10.6084/m9.figshare.30901598.v1
title: Supplementary Material for: Title: Hans-based cell of origin is not of prognostic significance in DLBCL patients; Retrospective single center study conducted in 326 RCHOP treated patients

description: Background: Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive lymphoma with dismal outcome after disease progression. Individual risk assessment can stratify patients into different treatment strategies.
Methods: We retrospectively collected data from 326 DLBCL patients treated in a single center with RCHOP from 01/2000 to 06/2023. Immunohistochemistry by Hans algorithm was used to classify patients according to cell of origin (COO). The Kaplan-Meier estimator of survival and Cox regression analysis were used.
Results: Time to progression (TTP) and overall survival (OS) were not different according to COO. Univariate analysis reveals international prognostic index (IPI), b2-microgloboulin ≥ 3,5 mg/L, bulky disease and abnormal LDH, but not Han’s defined COO, as the strongest predictors for progression. IPI score in multivariate analysis was the only prognostic factor for OS and together with high b2-microglobulin levels were independently prognostic factors for TTP. Accordingly, b2-microglobulin ≥ 3,5 mg/L was an independent prognostic factor for progression both in GC (HR 0,249 [(95% CI: 0,087-0,649), p=0,004] and non-GC DLBCL patients [HR 0,380 (95% CI: 0,177-0,813), p=0,011]. 
Conclusions: Cell of origin according to Hans Index is not a significant prognostic factor for DLBCL patients but b2 microglobulin ≥ 3,5 mg/L and IPI 2-5 in both GC and non-GC patients can predict individually a higher risk for progression.
DOI: 10.17026/ar/i1ijg1
title: PAN-00109183 - coin/coin-related, Duitse bezetting (1940-1945), 10 cent

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00109183&lt;/p&gt;
description: Modified: 2025-10-24T08:34:02+02:00
DOI: 10.6084/m9.figshare.30344017
title: Canine diet datasets

description: This study introduces an intelligent system for creating personalized wet-food diets for dogs using a hybrid combination of machine learning and optimization techniques. Unlike standard commercial dog foods, the proposed model tailors nutrition to each dog’s breed, age, size, activity level, and health condition. By integrating a large ingredient–nutrient database with veterinary guidelines, the system predicts the required nutrient and calorie levels and then uses linear programming to generate balanced recipes that meet all dietary constraints. The approach improves nutrient accuracy, recipe diversity, and veterinary compliance, offering a data-driven, transparent, and sustainable alternative to conventional one-size-fits-all pet diets.
DOI: 10.6084/m9.figshare.30344017.v1
title: Canine diet datasets

description: This study introduces an intelligent system for creating personalized wet-food diets for dogs using a hybrid combination of machine learning and optimization techniques. Unlike standard commercial dog foods, the proposed model tailors nutrition to each dog’s breed, age, size, activity level, and health condition. By integrating a large ingredient–nutrient database with veterinary guidelines, the system predicts the required nutrient and calorie levels and then uses linear programming to generate balanced recipes that meet all dietary constraints. The approach improves nutrient accuracy, recipe diversity, and veterinary compliance, offering a data-driven, transparent, and sustainable alternative to conventional one-size-fits-all pet diets.
DOI: 10.6084/m9.figshare.30344017.v2
title: Canine diet datasets

description: This study introduces an intelligent system for creating personalized wet-food diets for dogs using a hybrid combination of machine learning and optimization techniques. Unlike standard commercial dog foods, the proposed model tailors nutrition to each dog’s breed, age, size, activity level, and health condition. By integrating a large ingredient–nutrient database with veterinary guidelines, the system predicts the required nutrient and calorie levels and then uses linear programming to generate balanced recipes that meet all dietary constraints. The approach improves nutrient accuracy, recipe diversity, and veterinary compliance, offering a data-driven, transparent, and sustainable alternative to conventional one-size-fits-all pet diets.
DOI: 10.5281/zenodo.17960061
title: README.txt Commons Engineering Lab Book — Companion Documents (v0.2)

description: This Zenodo record contains companion documentation supporting The Commons Engineering Lab Book v0.1.
DOI: 10.5281/zenodo.17960062
title: README.txt Commons Engineering Lab Book — Companion Documents (v0.2)

description: This Zenodo record contains companion documentation supporting The Commons Engineering Lab Book v0.1.
DOI: 10.15468/dl.j4dxk9
title: Occurrence Download

description: A dataset containing 230 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (India, Pakistan)",
 "TaxonKey is Geranium wallichianum"
 ]
}

 The dataset includes 230 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055736-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17851233
title: Data for Tailoring microstructure to achieve exceptional strength-ductility synergy in additively manufactured Al0.75Mn0.25CoCrFeNi eutectic high-entropy alloy via annealing heat treatment

description: Raw data/original images from the OM,XRD, SEM, EDS, EBSD,TEM, microhardness and tenisle test for the article "Tailoring microstructure to achieve exceptional strength-ductility synergy in additively manufactured Al0.75Mn0.25CoCrFeNi eutectic high-entropy alloy via annealing heat treatment".
DOI: 10.25505/fiz.icsd.cc2p9jzj
title: CSD 2481828: Experimental Crystal Structure Determination

description: Related Article: Hamza Shoukat, Tamanna Pinky, Muhammad Sani Muhammad, Zaheer Masood, Arslan Akbar, Nobuyuki Yamamoto, Sharad Puri, David N. McIlroy, Bin Wang, Jakoah Brgoch, Bayram Saparov|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c04529
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pz6qm
title: CSD 2501691: Experimental Crystal Structure Determination

description: Related Article: Hamza Shoukat, Tamanna Pinky, Muhammad Sani Muhammad, Zaheer Masood, Arslan Akbar, Nobuyuki Yamamoto, Sharad Puri, David N. McIlroy, Bin Wang, Jakoah Brgoch, Bayram Saparov|2025|Inorg.Chem.|||doi:10.1021/acs.inorgchem.5c04529
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.34740/kaggle/dsv/14190053
title: e-IPO Indonesia Data - Investment
DOI: 10.6084/m9.figshare.30900275
title: Integrative Prognostic Model of Inflammatory Markers for Predicting Outcomes in Acute-on-Chronic Liver Failure Patients Undergoing Artificial Liver Support Therapy

description: This study aims to investigate the relationship between inflammatory markers and ACLF of varying etiologies by systematically comparing the 90-day prognostic predictive performance of several inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI). The analysis will be conducted in both viral and non-viral ACLF subgroups. The goal is to enhance etiology-directed individualized progn models and establish a theoretical foundation for targeted anti-inflammatory therapies tailored to specific patient subulations.
DOI: 10.6084/m9.figshare.30900275.v1
title: Integrative Prognostic Model of Inflammatory Markers for Predicting Outcomes in Acute-on-Chronic Liver Failure Patients Undergoing Artificial Liver Support Therapy

description: This study aims to investigate the relationship between inflammatory markers and ACLF of varying etiologies by systematically comparing the 90-day prognostic predictive performance of several inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI). The analysis will be conducted in both viral and non-viral ACLF subgroups. The goal is to enhance etiology-directed individualized progn models and establish a theoretical foundation for targeted anti-inflammatory therapies tailored to specific patient subulations.
DOI: 10.17026/ar/zy0r9y
title: PAN-00106125 - coin/coin-related, Augustus (27 v.-14 na Chr.), denarius

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00106125&lt;/p&gt;
description: Modified: 2025-07-07T09:25:48+02:00
DOI: 10.15468/dl.xm3pup
title: Occurrence Download

description: A dataset containing 605 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "TaxonKey is Lithobates catesbeianus"
 ]
}

 The dataset includes 605 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055737-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13130/rd_unimi/cmir61/ehyysm
title: Agosto_1897_Pagina_001.jpg

description: Bulletin of 1897/08/01
DOI: 10.13130/rd_unimi/cmir61/nwjlyc
title: Agosto_1897_Pagina_002.jpg

description: Bulletin of 1897/08/01
DOI: 10.13130/rd_unimi/cmir61/ujrdeu
title: Agosto_1897_Pagina_003.jpg

description: Bulletin of 1897/08/01