cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12176874
title: Global Survey of Plasma Sheet Electron Precipitation due to Whistler Mode Chorus Waves in Earth’s Magnetosphere

description: This is the data repository for the paper 'Global Survey of Plasma Sheet Electron Precipitation due to Whistler Mode Chorus Waves in Earth’s Magnetosphere', which is submitted to Geophysical Research Letters by Ma et al., 2020.<br>We include the data used to produce paper figures and Supporting Information figures, and the corresponding codes to read and plot the data.<br>Use the IDL code rbsp_chorus_precip_paperfig12.pro to load the satellite tplot variables which are also uploaded, and plot the data in Figure 1 and Figure 2.<br>The data in Figure 3, Figure 4, and Supporting Information Figures S1-S3 are in the ASCII files.
DOI: 10.6084/m9.figshare.6934049
title: Wu et al., 2018.zip

description: The weather, CTD and ADCP data across the Bohai Strait in Dec 2016 and May 2017
DOI: 10.6084/m9.figshare.12695418
title: Additional file 5 of Evolution of pogo, a separate superfamily of IS630-Tc1-mariner transposons, revealing recurrent domestication events in vertebrates

description: Additional file 5: Table S2. Distribution of pogo transposon domesticated proteins.
DOI: 10.6084/m9.figshare.12695412.v1
title: Additional file 3 of Evolution of pogo, a separate superfamily of IS630-Tc1-mariner transposons, revealing recurrent domestication events in vertebrates

description: Additional file 3: Table S1. Distribution of pogo transposons. List of all species/organism containing pogo transposon. For each species, the following information is provided: classification information of species, transposon Name ID, structural characteristics of representative transposon, including copy number (Blast hits &gt; 1000 bp and identity &gt; 80%), transposon (Tn) length, transposase (Tpase) length (&gt; 300 aa), TIR length, TIR end motif, TIR sequence, TSD, domains of transposase, and triad signature of the DDE domain, and genome coordinate and sequence of representative transposon.
DOI: 10.6084/m9.figshare.12695489
title: Additional file 3 of Overexpression of TGFβ1 in murine mesenchymal stem cells improves lung inflammation by impacting the Th17/Treg balance in LPS-induced ARDS mice

description: Additional file 3.
DOI: 10.6084/m9.figshare.12171195.v1
title: MicroRNA-4290 suppresses PDK1-mediated glycolysis to enhance the sensitivity of gastric cancer cell to cisplatin

description: The development of chemotherapy resistance significantly impairs the efficiency of chemotherapy, but the underlying mechanisms of chemotherapy resistance in gastric cancer (GC) are complicated and still need to be further explored. Here, we aimed to reveal the effects of miR-4290/PDK1 (pyruvate dehydrogenase kinase 1) axis on chemotherapy resistance of GC in vitro. The expression patterns of miR-4290 in GC tissues and cell lines were determined by real-time quantitative PCR. Kaplan-Meier was used to assess the relationship between miR-4290 expression levels and patients' overall survival. CCK-8 and flow cytometry technologies were applied to detect cell proliferation and apoptosis. The luciferase gene reporter assay was used to evaluate the interaction between miR-4290 and PDK1. miR-4290 was lowly expressed in GC tissues and cell lines, which was closely associated with the shorter overall survival of GC patients. miR-4290 mimics significantly inhibited cell proliferation and induced cell apoptosis, as well as induced a significant reduction in the expression of PDK1. Moreover, miR-4290 significantly inhibited glycolysis and decreased the IC50 value to cisplatin in SGC7901 cells, whereas these effects were abolished and cell apoptosis was promoted when PDK1 was overexpressed. In conclusion, this study revealed that miR-4290 suppressed PDK1-mediated glycolysis to enhance the sensitivity of GC cells to cisplatin.
DOI: 10.6084/m9.figshare.14788422
title: Additional file 2 of Genetic differentiation and restricted gene flow in rice landraces from Yunnan, China: effects of isolation-by-distance and isolation-by-environment

description: Additional file 2: Table S1. List of samples included in the study, including their origin and group. Table S2. Summary of sequenced genes and primer sequences used in this study. Table S3. Summary of nucleotide polymorphisms and neutrality tests. Table S4. The genetic diversity of rice landraces based on 48 SSRs. Table S5. The genetic diversity of rice landraces in each population. Table S6. Putative selective-sweep regions in subgroup jap-N. Table S7. Putative selective-sweep regions in subgroup jap-S. Table S8. Putative selective-sweep regions in subgroup ind-N. Table S9. Putative selective-sweep regions in subgroup ind-S. Table S10. Cloned genes located on the selection-sweep regions. Table S11. QTLs that overlapped with selection-sweep regions. Table S12. SNPs with absolute value greater than 6 for the first three components of 24 environmental factors. Table S13. SNPs with the top 25 highest |z|-scores among those candidate genes with known functions. Table S14. Summary of SSR markers and primer sequences. Table S15. The detailed information of 24 environmental factors in each population. Table S16. Summary of agronomic traits for rice landraces in each population. The value before the slash shows the data collection from Yunnan, and the value after the slash shows the data collection from Hainan.
DOI: 10.6084/m9.figshare.12695589.v1
title: Additional file 10 of Genome-wide association mapping reveals novel genes associated with coleoptile length in a worldwide collection of barley

description: Additional file 10 The dataset supporting the conclusions of this article. Sheet 1: The coleoptile length data including experiments conducted across two years (2017 and 2019) with a total of 16 biological replicates. The length unit is centimetre. Missing data due to germination failure is left blank; sheet 2: The single-nucleotide variants between short and long coleoptile haplotypes. 0 represented the reference allele and 1 represented the alternative allele; sheet 3: The raw data for SPL3 gene expression experiment; sheet 4: the coleoptile length variation between different alleles of high significant candidate genes.
DOI: 10.6084/m9.figshare.14268326
title: Identification and sequence analysis of prolactin receptor and its differential expression profile at various developmental stages in striped hamsters

description: Prolactin (PRL) plays critical roles in regulation of biological functions with the binding of specific prolactin receptor (PRLR). Revealing the expression patterns of PRLR at different developmental stages is beneficial to better understand the role of PRL and its mechanism of action in striped hamsters. In this study, the cDNA sequence of PRLR (2866-base-pairs) was harvested from the pituitary of mature female striped hamsters (Cricetulus barabensis) that contains an 834-base-pair 5′-untranslated region (1-834 bp), a 1848-base-pair open reading frame (835-2682 bp), and a 184-base-pair 3′-untranslated region (2683-2866). The 1848-base-pair open reading frame encodes a mature prolactin-binding protein of 592 amino acids. In the mature PRLR, two prolactin-binding motifs, 12 cysteines, and five potential Asn-linked glycosylation sites were detected. Our results showed that the PRLR mRNA quantity in the hypothalamus, pituitary, ovaries, or testis was developmental-stage-dependent, with the highest level at sub-adult stage and the lowest level at old stage. We also found that PRLR mRNAs were highest in pituitary, medium level in hypothalamus, and lowest in ovaries or testis. PRLR mRNAs were significantly higher in males than in females, except in the hypothalamus and pituitary from 7-week-old striped hamsters. Moreover, the PRLR mRNAs in the hypothalamus, pituitary, and ovaries or testis were positively correlated with the expression levels of GnRH in the hypothalamus. These results indicated that the PRLR has conserved domain in striped hamster, but also possesses specific character. PRLR has multiple biological functions including positively regulating reproduction in the striped hamster.
DOI: 10.6084/m9.figshare.14788564.v1
title: Additional file 1 of Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia

description: Additional file 1. Summary of sequence data from 24 samples.
DOI: 10.6084/m9.figshare.22132422
title: Myhre Syndrome Misdiagnosed as Marfan Syndrome: an Educational Presentation

description: Abstract A 32-month-old girl with patent ductus arteriosus, false tendon of left ventricle, mild pulmonary hypertension, and chronic cardiac insufficiency (cardiac function level I-II) was misdiagnosed with Marfan Syndrome and there was no improvement in her physical growth after operation for this disease. The preterm baby was finally diagnosed with Myhre Syndrome by clinical phenotypes and mutation of SMAD4 gene.
DOI: 10.25402/fsg.14798448
title: Supplementary Table 1. Computational drug repositioning for ischemic stroke: Neuroprotective drug discovery

description: Supplementary Table 1
DOI: 10.25402/fsg.14798451
title: Supplementary Table 3. Computational drug repositioning for ischemic stroke: Neuroprotective drug discovery

description: Supplementary Table 3<br>
DOI: 10.25402/fsg.14798454
title: Supplementary Table 5. Computational drug repositioning for ischemic stroke: Neuroprotective drug discovery

description: Supplementary Table 5
DOI: 10.25402/fsg.14798460
title: Supplementary Table 4. Computational drug repositioning for ischemic stroke: Neuroprotective drug discovery

description: Supplementary Table 4
DOI: 10.6084/m9.figshare.14788494
title: Additional file 2 of Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma

description: Additional file 2.
DOI: 10.6084/m9.figshare.7452443
title: Hydrogen Storage Properties and Reactive Mechanism of LiBH4/Mg10YNi-H Composite

description: The Mg10YNi alloy was hydrogenated and then coupled with LiBH4 to form LiBH4/Mg10YNi-H reactive hydride composite. The results indicate that thermal dehydrogenation stability of LiBH4 can be remarkably reduced by combining with Mg10YNi hydride. The starting and ending temperatures for hydrogen desorption from the LiBH4/Mg10YNi-H composite are approximately 275 and 430 ºC, respectively. Dehydrogenation of the LiBH4/Mg10YNi-H composite proceeds mainly in two steps with a total reaction of 12LiBH4 + 2.5Mg10YNiH20 → 24Mg + MgNi2.5B2 + 2.5YB4 + 12LiH + 43H2. After rehydrogenation at 450 ºC under 9 MPa hydrogen pressure, the LiBH4/Mg10YNi-H composite starts to release hydrogen around 260 ºC, and as much as approximately 5.2 wt.% of hydrogen can be desorbed during the second dehydrogenation process.
DOI: 10.6084/m9.figshare.14788494.v1
title: Additional file 2 of Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma

description: Additional file 2.
DOI: 10.25402/fsg.14798544
title: Supplementary Table 2. Computational drug repositioning for ischemic stroke: Neuroprotective drug discovery

description: Supplementary Table 2
DOI: 10.6084/m9.figshare.25195730.v1
title: Supplementary Material for: Influence of the Intracranial Contents on the Head Motion under Bone Conduction

description: Introduction: The mechanism of non-osseous bone conduction pathways, involving the intracranial contents (ICC) of the skull, is still not well understood. This study aims to investigate the influence of the ICC on the skull bone wave propagation, including dependence on stimulation location and coupling. 
Methods: Three Thiel embalmed whole-head cadaver specimens were studied before and after the removal of the ICC. Stimulation was via the electromagnetic actuators from commercial bone conduction hearing aids. Osseous pathways were sequentially activated by mastoid, forehead and BAHA location stimulation via a 5-Newton steel headband or percutaneously implanted screw. Non-osseous pathways were activated by stimulation on the eye and dura via a 5-Newton steel headband and a custom-made pneumatic holder. Under each test condition, the 3D motion of the superior skull bone was monitored at ~200 points. 
Results: The averaged response of the skull surface showed limited differences due to the removal of the ICC. In some isolated cases, the modal pattern on the skull surface showed a trend for an upshift (~1/2 octave) in the observed natural frequencies for drained heads. This was also consistent with an observed trend for an upshift in the transition frequency in the estimated deformation across the lateral surfaces of the temporal bones. Such changes were consistent with the expected reduction in mass and damping due to the absence of the ICC. 
Conclusion: Overall, the ICC affect to a limited extent the motion of the skull bone, with a limited trend for a reduction of its natural frequencies.
DOI: 10.6084/m9.figshare.12171213.v1
title: MALAT1 is involved in type I IFNs-mediated systemic lupus erythematosus by up-regulating OAS2, OAS3, and OASL

description: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an aberrant activation of immune cells partly due to the dysfunction of cytokines such as type I interferons (IFNs). Long non-coding RNA MALAT1 has been found to play a pathogenic role in SLE; however, the underlying mechanisms are still poorly understood. Bioinformatics analysis showed the up-regulation of type I IFN downstream effectors OAS2, OAS3, and OASL (OAS-like) in CD4+ T cells, CD19+ B cells, and CD33+ myeloid cells in patients with active SLE compared to healthy participants. In this study, peripheral blood mononuclear cells (PBMCs), CD19+ B, and CD4+ T cells were isolated from active SLE patients and healthy participants. PCR was performed to quantify MALAT1, OAS2, OAS3, and OASL expression in immune cells. MALAT1, OAS2, OAS3, and OASL were knocked down in CD4+ T cells to investigate the regulatory effect of MALAT1 on the effectors and their involvement in type I IFNs-mediated inflammation. Results showed higher OAS2, OAS3, and OASL expression in active SLE patients. MALAT1 expression was positively correlated to OAS2, OAS3, and OASL expression in CD19+ B or CD4+ T cells. MALAT1 knockdown decreased OAS2, OAS3, and OASL expression. Treatment with IFN-α-2a increased the expression of TNF-α, IL-1β, and IFN-α in CD4+ T cells. However, knockdown of MALAT1, OAS2, OAS3, and OASL alone inhibited the effect of IFN-α-2a on TNF-α and IL-1β. This study suggested the involvement of MALAT1 in type I IFNs-mediated SLE by up-regulating OAS2, OAS3, and OASL.
DOI: 10.6084/m9.figshare.22132533.v1
title: WeChat-Assisted Preoperative Health Education Reduces Burden of Care on Parents of Children with Simple Congenital Heart Disease: a Prospective Randomized Controlled Study

description: Abstract Objective: The purpose of this study was to explore the clinical effect of preoperative health education based on the WeChat platform for parents of children with simple congenital heart disease. Methods: In this study, participants were randomly divided into an intervention group (WeChat group, n=40) and a control group (leaflet group, n=40) in our center. All parents were required to complete the Family Caregiver Task Inventory (FCTI) on the first visit and the Zarit Burden Interview (ZBI) and FCTI before the operation. Clinical, family and relevant data from children and parents were collected and subsequently analyzed. Results: Before the operation, the FCTI score and the ZBI score in the WeChat group were significantly lower than those in the control group (P=0.010, P=0.027, respectively). Compared to the FCTI score on the first visit, the preoperative status score was significantly lower in the WeChat group (P=0.008). The rate of loss to follow-up and complications in the WeChat group was also significantly lower than in the control group (P=0.003). Conclusion: Preoperative health education assisted by the WeChat platform for parents of children with simple congenital heart disease can effectively improve the parents' care ability and reduce the burden of care, preoperative complications and the rate of loss to follow-up.
DOI: 10.6084/m9.figshare.6934367
title: Effects of <i>AANAT</i> overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels

description: To explore the anti-inflammatory activity of endogenous produced melatonin, a melatonin-enriched animal model (goat) with <i>AANAT</i> transfer was successfully generated with somatic cell nuclear transfer (SCNT) technology. Basically, a pIRES2-EGFP-<i>AANAT</i> expression vector was constructed and was transferred into the female fetal fibroblast cells (FFCs) via electrotransfection and then the nuclear of the transgenic FFC was transferred to the eggs of the donor goats. The peripheral blood mononuclear cells (PBMCs) of the transgenic offspring expressed significantly higher levels of <i>AANAT</i> and melatonin synthetic function than those PBMCs from the wild-type (WT) animals. After challenge with lipopolysaccharide (LPS), the transgenic PBMCs had increased autophagosomes and <i>LC3B</i> expression while they exhibited suppressed production of the proinflammatory cytokines, IL1B and IL12 (IL12A-IL12B/p70), compared to their WT. The mechanistic analysis indicated that the anti-inflammatory activity of endogenous melatonin was mediated by MTNR1B (melatonin receptor 1B). MTNR1B stimulation activated the MAPK14 signaling pathway to promote cellular macroautophagy/autophagy, thus, suppressing the excessive inflammatory response of cellular. However, when the intact animals challenged with LPS, the serum proinflammatory cytokines were significantly higher in the transgenic goats than that in the WT. The results indicated that endogenous melatonin inhibited the MAPK1/3 signaling pathway and ROS production, subsequently downregulated gene expression of <i>BECN1, ATG5</i> in PMBCs and then suppressed the autophagy activity of PBMCs and finally elevated levels of serum proinflammatory cytokines in transgenic animals, Herein we provided a novel melatonin-enriched animal model to study the potential effects of endogenously produced melatonin on inflammatory responses and autophagy activity.
DOI: 10.6084/m9.figshare.6934367.v1
title: Effects of <i>AANAT</i> overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels

description: To explore the anti-inflammatory activity of endogenous produced melatonin, a melatonin-enriched animal model (goat) with <i>AANAT</i> transfer was successfully generated with somatic cell nuclear transfer (SCNT) technology. Basically, a pIRES2-EGFP-<i>AANAT</i> expression vector was constructed and was transferred into the female fetal fibroblast cells (FFCs) via electrotransfection and then the nuclear of the transgenic FFC was transferred to the eggs of the donor goats. The peripheral blood mononuclear cells (PBMCs) of the transgenic offspring expressed significantly higher levels of <i>AANAT</i> and melatonin synthetic function than those PBMCs from the wild-type (WT) animals. After challenge with lipopolysaccharide (LPS), the transgenic PBMCs had increased autophagosomes and <i>LC3B</i> expression while they exhibited suppressed production of the proinflammatory cytokines, IL1B and IL12 (IL12A-IL12B/p70), compared to their WT. The mechanistic analysis indicated that the anti-inflammatory activity of endogenous melatonin was mediated by MTNR1B (melatonin receptor 1B). MTNR1B stimulation activated the MAPK14 signaling pathway to promote cellular macroautophagy/autophagy, thus, suppressing the excessive inflammatory response of cellular. However, when the intact animals challenged with LPS, the serum proinflammatory cytokines were significantly higher in the transgenic goats than that in the WT. The results indicated that endogenous melatonin inhibited the MAPK1/3 signaling pathway and ROS production, subsequently downregulated gene expression of <i>BECN1, ATG5</i> in PMBCs and then suppressed the autophagy activity of PBMCs and finally elevated levels of serum proinflammatory cytokines in transgenic animals, Herein we provided a novel melatonin-enriched animal model to study the potential effects of endogenously produced melatonin on inflammatory responses and autophagy activity.
DOI: 10.6084/m9.figshare.14268298
title: MicroRNA-146a inhibition promotes total neurite outgrowth and suppresses cell apoptosis, inflammation, and STAT1/MYC pathway in PC12 and cortical neuron cellular Alzheimer's disease models

description: This study aimed to explore the effect of microRNA (miR)-146a inhibition on regulating cell apoptosis, total neurite outgrowth, inflammation, and STAT1/MYC pathway in Alzheimer's disease (AD). PC12 and cortical neuron cellular AD models were constructed by Aβ1-42 insult. For the former model, nerve growth factor (NGF) stimulation was previously conducted. miR-146a inhibitor and negative-control (NC) inhibitor were transfected into the two cellular AD models, and then cells were named miR-inhibitor group and NC-inhibitor group, respectively. After transfection, cell apoptosis, total neurite outgrowth, supernatant inflammation cytokines, and STAT1/MYC pathway were detected. miR-146a expression was similar between PC12 cellular AD model and control cells (NGF-stimulated PC12 cells), while miR-146a expression was increased in cortical neuron cellular AD model compared with control cells (rat embryo primary cortical neurons). In both PC12 and cortical neuron cellular AD models, miR-146a expression was reduced in miR-inhibitor group compared with NC-inhibitor group after transfection. Furthermore, cell apoptosis was attenuated, while total neurite outgrowth was elevated in miR-inhibitor group compared with NC-inhibitor group. As for supernatant inflammatory cytokines, tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-17 levels were lower in miR-inhibitor group than in NC-inhibitor group. Additionally, STAT1 and c-Myc mRNA and protein expressions were attenuated in miR-inhibitor group compared with NC-inhibitor group. In conclusion, miR-146a potentially represented a viable therapeutic target for AD.
DOI: 10.5281/zenodo.10638955
title: Accra OSeMOSYS Base Model

description: The base Accra energy system model built in OSeMOSYS.
DOI: 10.5281/zenodo.10638956
title: Accra OSeMOSYS Base Model

description: The base Accra energy system model built in OSeMOSYS.
DOI: 10.5519/qd.782lfxn9
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (5399360 records)
DOI: 10.6084/m9.figshare.7458803
title: Estimation of Heterogeneous Individual Treatment Effects With Endogenous Treatments

description: This article estimates <i>individual treatment effects</i> (ITE) and its probability distribution in a triangular model with binary-valued endogenous treatments. Our estimation procedure takes two steps. First, we estimate the counterfactual outcome and hence, the ITE for every observational unit in the sample. Second, we estimate the ITE density function of the whole population. Our estimation method does not suffer from the ill-posed inverse problem associated with inverting a nonlinear functional. Asymptotic properties of the proposed method are established. We study its finite sample properties in Monte Carlo experiments. We also illustrate our approach with an empirical application assessing the effects of 401(k) retirement programs on personal savings. Our results show that there exists a small but statistically significant proportion of individuals who experience negative effects, although the majority of ITEs is positive. Supplementary materials for this article are available online.