cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8128007.v1
title: Cognitive functions in children with congenital adrenal hyperplasia

description: ABSTRACT Objective There is controversy regarding cognitive function in patients with congenital adrenal hyperplasia (CAH). This study is aimed at the assessment of cognitive functions in children with CAH, and their relation to hydrocortisone (HC) therapy and testosterone levels. Subjects and methods Thirty children with CAH due to 21 hydroxylase deficiency were compared with twenty age- and sex-matched healthy controls. HC daily and cumulative doses were calculated, the socioeconomic standard was assessed, and free testosterone was measured. Cognitive function assessment was performed using the Wechsler Intelligence Scale – Revised for Children and Adults (WISC), the Benton Visual Retention Test, and the Wisconsin Card Sorting Test (WCST). Results The mean age (SD) of patients was 10.22 (3.17) years [11 males (36.7%), 19 females (63.3%)]. Mean (SD) HC dose was 15.78 (4.36) mg/m 2 /day. Mean (SD) cumulative HC dose 44,689. 9 (26,892.02) mg. Patients had significantly lower scores in all domains of the WISC test, performed significantly worse in some components of the Benton Visual Retention Test, as well as in the Wisconsin Card Sorting Test. There was no significant difference in cognitive performance when patients were subdivided according to daily HC dose (&lt; 10, 10 – 15, &gt; 15 mg/m 2 /day). A positive correlation existed between cumulative HC dose and worse results of the Benton test. No correlation existed between free testosterone and any of the three tests. Conclusion Patients with CAH are at risk of some cognitive impairment. Hydrocortisone therapy may be implicated. This study highlights the need to assess cognitive functions in CAH.
DOI: 10.6084/m9.figshare.8128001
title: Disability as a determinant of fatigue in MS patients

description: ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p &lt; 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.
DOI: 10.6084/m9.figshare.8127998
title: A New methodology of Nondestructive Testing for Quantitative Evaluation of Sigma Phase in Duplex Stainless Steels

description: Duplex Stainless Steels (DSSs) are widely used in the oil and gas industry. When the steel is subjected to a thermal gradient, as in welding may occur precipitation of intermetallic phases. Among these phases, there is the sigma phase, which even in small quantities reduces drastically the mechanical and corrosion resistance properties. According to some studies in the literature, the limit amount of sigma phase present in steel in welded joints must be in a maximum volume fraction of 2,5%. In search to improve the detection sensitivity of the sigma phase, this paper presents results obtained by Linear Sweep Voltammetry (LSV) in Duplex Stainless Steel UNS S31803 as a Nondestructive Testing (NDT) model. The innovation in the application of this test is to use a microcell-based system that allows a reduced area of analysis obtaining density of currents in the order of microamperes and in the use of selective electrolytes to the elements of the oxides present in the intermetallic phases. With the use of these systems and through the optimization of control parameters it was possible to detect very low amounts of deleterious phases such as the sigma and chi phases.
DOI: 10.6084/m9.figshare.8128001.v1
title: Disability as a determinant of fatigue in MS patients

description: ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p &lt; 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.
DOI: 10.6084/m9.figshare.8127998.v1
title: A New methodology of Nondestructive Testing for Quantitative Evaluation of Sigma Phase in Duplex Stainless Steels

description: Duplex Stainless Steels (DSSs) are widely used in the oil and gas industry. When the steel is subjected to a thermal gradient, as in welding may occur precipitation of intermetallic phases. Among these phases, there is the sigma phase, which even in small quantities reduces drastically the mechanical and corrosion resistance properties. According to some studies in the literature, the limit amount of sigma phase present in steel in welded joints must be in a maximum volume fraction of 2,5%. In search to improve the detection sensitivity of the sigma phase, this paper presents results obtained by Linear Sweep Voltammetry (LSV) in Duplex Stainless Steel UNS S31803 as a Nondestructive Testing (NDT) model. The innovation in the application of this test is to use a microcell-based system that allows a reduced area of analysis obtaining density of currents in the order of microamperes and in the use of selective electrolytes to the elements of the oxides present in the intermetallic phases. With the use of these systems and through the optimization of control parameters it was possible to detect very low amounts of deleterious phases such as the sigma and chi phases.
DOI: 10.6084/m9.figshare.8127995
title: Estimation of optimum experimental plot size for taro culture

description: ABSTRACT: Taro is a tropical tuberous vegetable that produces cormels of high nutritional and energetic value. In recent years, its cultivation has expanded, creating the need for more research. However, the experimental plot size interferes directly with the precision of the experiment.Literature describes several methods for establishing the optimum experimental plot size. The objective of the current research was to estimate the optimal experimental plot size for taro culture, utilizing the Modified Maximum Curvature Method. The field experiment was conducted in the vegetable garden of the Departamentode Fitotecnia of Universidade Federal de Viçosa, from September 2011 to June 2012, with Japanese taro. Twenty-two rows with 20 plants each were planted, at 1.0×0.3 m spacing, considering the 20 central rows with 18 plants each as useful area, totaling 360 plants. Each plant corresponded to a basic unit (BU). Once the possible clusters were made, 23 different plot sizes were formed. At harvest, the fresh mass characteristics of large, medium, and marketable cormels were evaluated. The optimum plot sizes were: 8.77 BU for marketable cormels; 14.75 BU for large cormels, and 13.37 BU for medium cormels. Among the plot sizes estimated in this study, the aim was to improve precision of experiments performed with taro, plots formed by 15 BU that corresponded to a 4.5 m2 area are recommended.
DOI: 10.6084/m9.figshare.8127992
title: EFFECTIVENESS OF FIXED DOSES OF PROPRANOLOL IN THE TREATMENT OF HEMANGIOMAS REGARDLESS OF CHILD’S WEIGHT GAIN: A CASE REPORT

description: ABSTRACT Objective: To present the outcomes of fixed doses of propranolol tablets for the treatment of hemangiomas. Case description: Two illustrative cases of hemangioma in infant patients younger than six months old are described. Treatments were started in 2010 and 2011 and were monitored until August 2017. Patients were treated with fixed doses, initially calculated based on the upper limit of 3 mg/kg/day and administrated in two daily doses rounded down to the nearest multiple of five milligrams. Dosage was not adjusted to patients’ weight gain. The tablets were crushed and then diluted in a maximum amount of 3 mL of water. This procedure was necessary because propranolol was not available in oral solution in 2009, when dosages available in the Brazilian market were 10, 40 and 80 mg. Both patients presented significative improvement in the first 60 days and were in complete remission by the end of the treatment. Comments: It is possible to treat patients with Propranolol 10 mg tablets, even though the dosage is not as precise as when calculated according to patients’ weight. The maintenance of a fixed dose, ignoring the patient’s progressive weight gains, helps avoiding the rebound effect and decreases complications.
DOI: 10.6084/m9.figshare.8127995.v1
title: Estimation of optimum experimental plot size for taro culture

description: ABSTRACT: Taro is a tropical tuberous vegetable that produces cormels of high nutritional and energetic value. In recent years, its cultivation has expanded, creating the need for more research. However, the experimental plot size interferes directly with the precision of the experiment.Literature describes several methods for establishing the optimum experimental plot size. The objective of the current research was to estimate the optimal experimental plot size for taro culture, utilizing the Modified Maximum Curvature Method. The field experiment was conducted in the vegetable garden of the Departamentode Fitotecnia of Universidade Federal de Viçosa, from September 2011 to June 2012, with Japanese taro. Twenty-two rows with 20 plants each were planted, at 1.0×0.3 m spacing, considering the 20 central rows with 18 plants each as useful area, totaling 360 plants. Each plant corresponded to a basic unit (BU). Once the possible clusters were made, 23 different plot sizes were formed. At harvest, the fresh mass characteristics of large, medium, and marketable cormels were evaluated. The optimum plot sizes were: 8.77 BU for marketable cormels; 14.75 BU for large cormels, and 13.37 BU for medium cormels. Among the plot sizes estimated in this study, the aim was to improve precision of experiments performed with taro, plots formed by 15 BU that corresponded to a 4.5 m2 area are recommended.
DOI: 10.6084/m9.figshare.8127992.v1
title: EFFECTIVENESS OF FIXED DOSES OF PROPRANOLOL IN THE TREATMENT OF HEMANGIOMAS REGARDLESS OF CHILD’S WEIGHT GAIN: A CASE REPORT

description: ABSTRACT Objective: To present the outcomes of fixed doses of propranolol tablets for the treatment of hemangiomas. Case description: Two illustrative cases of hemangioma in infant patients younger than six months old are described. Treatments were started in 2010 and 2011 and were monitored until August 2017. Patients were treated with fixed doses, initially calculated based on the upper limit of 3 mg/kg/day and administrated in two daily doses rounded down to the nearest multiple of five milligrams. Dosage was not adjusted to patients’ weight gain. The tablets were crushed and then diluted in a maximum amount of 3 mL of water. This procedure was necessary because propranolol was not available in oral solution in 2009, when dosages available in the Brazilian market were 10, 40 and 80 mg. Both patients presented significative improvement in the first 60 days and were in complete remission by the end of the treatment. Comments: It is possible to treat patients with Propranolol 10 mg tablets, even though the dosage is not as precise as when calculated according to patients’ weight. The maintenance of a fixed dose, ignoring the patient’s progressive weight gains, helps avoiding the rebound effect and decreases complications.
DOI: 10.6084/m9.figshare.8127980
title: BODY MASS INDEX AND ALBUMIN LEVELS ARE ASSOCIATED WITH PULMONARY FUNCTION PARAMETERS IN PEDIATRIC SUBJECTS WITH CYSTIC FIBROSIS

description: ABSTRACT Objective: To evaluate the association of body mass index (BMI) and albumin with pulmonary function in cystic fibrosis (CF) pediatric subjects. Methods: This is a cross-sectional study with clinically stable CF’s subjects. Clinical (pulmonary function) and nutritional evaluation (body mass index and albumin) were performed. Univariate analysis was performed using simple linear correlations. Regression analysis was performed using an exit level of p&lt;0.05. Results: Seventy-eight CF’s subjects (mean age 12.8±3.8 years) with mean albumin 4.2±0.4 mg/dL, predicted forced expiratory volume in 1 second (FEV1%) 80.8±22.6 and BMI median percentile 51.2 (1.3-97.7). In the multiple regression models, albumin, age and BMI percentile were associated with pulmonary function. Subjects with lower than 25 BMI percentile had 12.2% lower FEV1%. An albumin increase of 0.1 mg was associated with 2.7% increase in predicted FEV1%, and one year increase in age was associated with reduction in 1.2% of predicted FEV1%. Conclusions: BMI percentile, albumin and age were independently associated with predicted FEV1% in a tertiary referral hospital.
DOI: 10.6084/m9.figshare.8127980.v1
title: BODY MASS INDEX AND ALBUMIN LEVELS ARE ASSOCIATED WITH PULMONARY FUNCTION PARAMETERS IN PEDIATRIC SUBJECTS WITH CYSTIC FIBROSIS

description: ABSTRACT Objective: To evaluate the association of body mass index (BMI) and albumin with pulmonary function in cystic fibrosis (CF) pediatric subjects. Methods: This is a cross-sectional study with clinically stable CF’s subjects. Clinical (pulmonary function) and nutritional evaluation (body mass index and albumin) were performed. Univariate analysis was performed using simple linear correlations. Regression analysis was performed using an exit level of p&lt;0.05. Results: Seventy-eight CF’s subjects (mean age 12.8±3.8 years) with mean albumin 4.2±0.4 mg/dL, predicted forced expiratory volume in 1 second (FEV1%) 80.8±22.6 and BMI median percentile 51.2 (1.3-97.7). In the multiple regression models, albumin, age and BMI percentile were associated with pulmonary function. Subjects with lower than 25 BMI percentile had 12.2% lower FEV1%. An albumin increase of 0.1 mg was associated with 2.7% increase in predicted FEV1%, and one year increase in age was associated with reduction in 1.2% of predicted FEV1%. Conclusions: BMI percentile, albumin and age were independently associated with predicted FEV1% in a tertiary referral hospital.
DOI: 10.6084/m9.figshare.8127977
title: TRAINING OF CHILDREN’S AND ADOLESCENTS’ FAMILY MEMBERS IN HOME PARENTERAL NUTRITION CARE

description: ABSTRACT Objective: To report the experience of the training in home parenteral nutrition (PN) directed to family members of children and adolescents participating in a multidisciplinary intestinal rehabilitation program of a tertiary public hospital. Methods: Cross-sectional descriptive study with family caregivers of patients from the Intestinal Rehabilitation Program of Hospital de Clínicas de Porto Alegre, RS, Brazil, from July/2014 to January/2017. Inclusion criteria: family members of children aged 30 days to 17 years and estimated PN use ≥8 weeks; and family members motivated to care for the child. The training covered: hand washing and disinfection; infusion pump handling; and central venous catheter (CVC) and PN care. Outcomes assessed: catheter-related bloodstream infection (CRBSI) rate, accidental CVC exit, end of PN infusion with more than 60minutes of delay or advance compared to the time predicted, mechanical obstruction, bleeding in the CVC insertion site, and death. Results: Twenty-seven family members of 17 children were trained. Their median age was 28 (18-60) years, and 63% were mothers. The mean CRBSI rate was 1.7/1,000 days of CVC use, and 29.4% of patients had at least one episode of accidental CVC exit. There were no complications related to PN infusion, bleeding, or death. Conclusions: The training of family caregivers allowed the safe implementation of home PN, with the active participation of families, making the procedure feasible in the public health system in Brazil.
DOI: 10.6084/m9.figshare.8127977.v1
title: TRAINING OF CHILDREN’S AND ADOLESCENTS’ FAMILY MEMBERS IN HOME PARENTERAL NUTRITION CARE

description: ABSTRACT Objective: To report the experience of the training in home parenteral nutrition (PN) directed to family members of children and adolescents participating in a multidisciplinary intestinal rehabilitation program of a tertiary public hospital. Methods: Cross-sectional descriptive study with family caregivers of patients from the Intestinal Rehabilitation Program of Hospital de Clínicas de Porto Alegre, RS, Brazil, from July/2014 to January/2017. Inclusion criteria: family members of children aged 30 days to 17 years and estimated PN use ≥8 weeks; and family members motivated to care for the child. The training covered: hand washing and disinfection; infusion pump handling; and central venous catheter (CVC) and PN care. Outcomes assessed: catheter-related bloodstream infection (CRBSI) rate, accidental CVC exit, end of PN infusion with more than 60minutes of delay or advance compared to the time predicted, mechanical obstruction, bleeding in the CVC insertion site, and death. Results: Twenty-seven family members of 17 children were trained. Their median age was 28 (18-60) years, and 63% were mothers. The mean CRBSI rate was 1.7/1,000 days of CVC use, and 29.4% of patients had at least one episode of accidental CVC exit. There were no complications related to PN infusion, bleeding, or death. Conclusions: The training of family caregivers allowed the safe implementation of home PN, with the active participation of families, making the procedure feasible in the public health system in Brazil.
DOI: 10.6084/m9.figshare.8127974
title: CASE SERIES OF PATIENTS UNDER BIWEEKLY TREATMENT WITH LARONIDASE: A REPORT OF A SINGLE CENTER EXPERIENCE

description: ABSTRACT Objective: To report the stabilization of urinary glycosaminoglicans (GAG) excretion and clinical improvements in patients with mucopolysaccharidosis type I (MPS I) under an alternative dose regimen of laronidase of 1.2 mg/kg every other week. Methods: We participated in a dose-optimization trial for laronidase in MPS-I patients using four alternative regimens: 0.58 mg/kg every week, 1.2 mg/kg every two weeks, 1.2 mg/kg every week and 1.8 mg/kg every other week (EOW). After the trial ended, the patients resumed the recommended dose and regimen of 0.58 mg/kg every week. Under this regimen, some patients presented difficulties in venous access and were unable to commute weekly to the treatment center. Therefore, we used an alternative regimen that consisted of 1.2 mg/kg EOW in eight patients. A retrospective study of medical records of MPS-I patients who underwent both enzyme replacement therapy (ERT) regimens, of 0.58 mg/kg every week and 1.2 mg/kg EOW, was done. Results: Patients remained clinically stable under the alternative regimen, did not present elevation of urinary GAG nor any adverse event. Conclusions: The switch of dose regimen to 1.2 mg/kg EOW of laronidase was safe, and did not cause any clinical worsening in patients who had been previously under standard dose ERT.
DOI: 10.6084/m9.figshare.8127974.v1
title: CASE SERIES OF PATIENTS UNDER BIWEEKLY TREATMENT WITH LARONIDASE: A REPORT OF A SINGLE CENTER EXPERIENCE

description: ABSTRACT Objective: To report the stabilization of urinary glycosaminoglicans (GAG) excretion and clinical improvements in patients with mucopolysaccharidosis type I (MPS I) under an alternative dose regimen of laronidase of 1.2 mg/kg every other week. Methods: We participated in a dose-optimization trial for laronidase in MPS-I patients using four alternative regimens: 0.58 mg/kg every week, 1.2 mg/kg every two weeks, 1.2 mg/kg every week and 1.8 mg/kg every other week (EOW). After the trial ended, the patients resumed the recommended dose and regimen of 0.58 mg/kg every week. Under this regimen, some patients presented difficulties in venous access and were unable to commute weekly to the treatment center. Therefore, we used an alternative regimen that consisted of 1.2 mg/kg EOW in eight patients. A retrospective study of medical records of MPS-I patients who underwent both enzyme replacement therapy (ERT) regimens, of 0.58 mg/kg every week and 1.2 mg/kg EOW, was done. Results: Patients remained clinically stable under the alternative regimen, did not present elevation of urinary GAG nor any adverse event. Conclusions: The switch of dose regimen to 1.2 mg/kg EOW of laronidase was safe, and did not cause any clinical worsening in patients who had been previously under standard dose ERT.
DOI: 10.6084/m9.figshare.8127971
title: Body appreciation and associated factors among adolescents and young women

description: ABSTRACT Objective: To investigate the factors that influence the body appreciation among adolescents and young women. Methods: Participants (n = 242) answered questionnaires that assessed body appreciation, body dissatisfaction, sociocultural influence, eating attitudes and self-esteem. Results: The correlation analysis revealed that all variables were associated with body appreciation. The multiple linear regression model pointed to body satisfaction as the main predictor of greater body appreciation, followed by self-esteem, eating attitudes and a lower influence of the media. Conclusions: These results contribute to the understanding of positive body image among Brazilian adolescents and youngsters, pointing out important issues and challenges for future research.
DOI: 10.6084/m9.figshare.8127971.v1
title: Body appreciation and associated factors among adolescents and young women

description: ABSTRACT Objective: To investigate the factors that influence the body appreciation among adolescents and young women. Methods: Participants (n = 242) answered questionnaires that assessed body appreciation, body dissatisfaction, sociocultural influence, eating attitudes and self-esteem. Results: The correlation analysis revealed that all variables were associated with body appreciation. The multiple linear regression model pointed to body satisfaction as the main predictor of greater body appreciation, followed by self-esteem, eating attitudes and a lower influence of the media. Conclusions: These results contribute to the understanding of positive body image among Brazilian adolescents and youngsters, pointing out important issues and challenges for future research.