cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21758285.v1
title: Supplementary Material for: Neurochemical profile of BRAFV600E/AktT308D/S473D mouse gangliogliomas reveals impaired GABAergic system inhibition

description: Gangliogliomas (GGs), composed of dysmorphic neurons and neoplastic astroglia, represent the most frequent tumor entity associated with chronic recurrent epileptic seizures. So far, a systematic analysis of potential differences in neurochemical profiles of dysmorphic tumoral neurons as well as neurons of the peritumoral microenvironment (PTME) was hampered by the inability to unequivocally differentiate between the distinct neuronal components in human GG biopsies. Here, we have applied a novel GG mouse model that allows to clearly resolve the neurochemical profiles of GG-intrinsic versus PTME neurons. For this purpose, glioneuronal tumors in mice were induced by intraventricular in utero electroporation (IUE) of piggyBac-based plasmids for BRAFV600E and activated Akt (AktT308D/S473D, further referred to as AktDD) and analyzed neurochemically by immunocytochemistry against specific marker proteins. IUE of BRAFV600E/AktDD in mice resulted in tumors with the morphological features of human GGs. Our immunocytochemical analysis revealed a strong reduction of GABAARα1 immunoreactivity in the tumor compared to the PTME. In contrast, the extent of NMDAR1 immunoreactivity in the tumor appeared comparable to the PTME. Interestingly, tumor cells maintained the potential to express both receptors. Fittingly, the abundance of the presynaptic vesicular neurotransmitter transporters VGLUT1 and VGAT was also decreased in the tumor. Additionally, the fraction of parvalbumin and somatostatin non-neoplastic interneurons was reduced. In conclusion, changes in the levels of key proteins in neurotransmitter signaling suggest a loss of synapses and may thereby lead to neuronal network alterations in mouse GGs.
DOI: 10.6084/m9.figshare.6025238.v5
title: DEMETER2 data

description: Cancer cell line genetic dependencies estimated using the DEMETER2 model. DEMETER2 is applied to three large-scale RNAi screening datasets: the Broad Institute Project Achilles, Novartis Project DRIVE, and the Marcotte et al. breast cell line dataset. The model is also applied to generate a combined dataset of gene dependencies covering a total of 712 unique cancer cell lines. For more information visit https://depmap.org/R2-D2/. <br>Visit the Cancer Dependency Map portal at https://depmap.org to explore related datasets. Email questions to depmap@broadinstitute.org <br>This dataset includes gene dependencies estimated using the DEMETER2 model, the raw input datasets used to fit the models, as well as associated metadata. See Readme file for more details about the dataset contents and version history.<br>-------------------------------------------------------------------Version history: (see README for more details)-------------------------------------------------------------------v1: Initial data release<br>v2: - Removed small number of non-human genes (e.g. GFP, RFP) from shRNA-to-gene mapping - Updated cell line names to be consistent with DepMap names, according to the following map (old -&gt; new):<br>v3: Added estimated seed effect matrices<br>v4: Added RNAseq and mutation data files used in analysis for manuscript<br>v5: Fixed minor bug with Marcotte LFC data that caused hairpins targeting multiple genes to appear multiple times in the LFC matrix. This created bias in the seed effect estimates for those hairpins, causing very minor differences to the resulting model parameters.<br>
DOI: 10.6084/m9.figshare.22643974.v1
title: High thermal variation in maximum temperatures invert Brett’s heat-invariant rule at fine spatial scales

description: Sheet 1 Raw data (Author´s order) CTmax and CTmin Sheet 2 Mean, variance and variance ratios of CTmax and CTmin of large and local spatial scale studies (Figure 3 entries order)
DOI: 10.6084/m9.figshare.25857295.v1
title: Supplementary Data S1.xlsx

description:  
<strong>Supplementary Data S1.xlsx</strong>
DOI: 10.6084/m9.figshare.9273524.v1
title: Littorina obtusata raw transcriptome assembly

description: Raw transcriptome assembly of Littorina obtusata based on the sequencing reads (Illumina) from a single individual (whole body except hepatopancreas).
DOI: 10.23645/epacomptox.27696612.v1
title: ExpoPath: A Method for Identifying and Annotating Exposure Pathways from Chemical Co-occurrence Networks

description: Dataset for "ExpoPath: A Method for Identifying and Annotating Exposure Pathways from Chemical Co-occurrence Networks." Science of the Total Environment (2025).Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25<br>
DOI: 10.6084/m9.figshare.7356638.v1
title: Additional file 6: of Construction of a high-density genetic map: genotyping by sequencing (GBS) to map purple seed coat color (Psc) in hulless barley

description: Gene annotations of 7H within the region encompassing 90.50â 90.70Â cM. (XLSX 25 kb)
DOI: 10.6084/m9.figshare.15078498.v1
title: The Acceptability and side effects of COVID 19 vaccine among health care workers in Nigeria: a cross sectional study

description: Underlying data of Acceptability and side effects of COVID 19 vaccine among health care workers in Nigeria.
DOI: 10.6084/m9.figshare.22492804.v1
title: Supplementary File 19

description: Multiple sequence alignment and MrBayes options and parameter values of Hnrnpa genes, in Nexus format. Related to Extended Data Figure 4c.
DOI: 10.6084/m9.figshare.24551992.v1
title: NEST - UMAR Energy Demand and User Practice Data

description: Measurement data for the UMAR building at NEST. The dataset consists of 27 measurement points with a temporal resolution of 1 minute. The data has been recorded over the duration of one year (July 2019 to July 2023). Metadata for each measurement point is stored in a separate file on this repository.
DOI: 10.6084/m9.figshare.7957346.v1
title: Context-based-ABCmodel(FUS-TARDBP)

description: This is the results from Context-based-ABCmodel for FUS-TARDBP relation.Each file shows results according to similarity difference.<br>
DOI: 10.6084/m9.figshare.28230068.v1
title: Effectiveness of medical diagnosis versus diagnostic artificial intelligence algorithms in detecting communicable diseases

description: Database of notifiable diseases with diagnosis by physician versus diagnosis by artificial intelligence
DOI: 10.6084/m9.figshare.19424015.v13
title: Neocortical Localization and Thalamocortical Modulation of Neuronal Hyperexcitability contribute to Fragile X Syndrome: Source Data and Code for Figures and Statistics

description: Source data for manuscript as requested by publisher.
DOI: 10.6084/m9.figshare.25733580.v1
title: Sleep5_1.sav to repository.sav

description: Psychological distress and sleep quality among Sri Lankan medical students during an economic crisis
DOI: 10.6084/m9.figshare.28237481.v2
title: Source_data.xlsx

description: Source data
DOI: 10.23645/epacomptox.22272439.v1
title: Weight of Evidence for Cross-Species Conservation of Androgen Receptor-Based Biological Activity (ORD-050503)

description: Dataset for "Vliet, S., K. Markey, S. Lynn, A. Adetona, D. Fallacara, P. Ceger, N. Choski, A. Karmaus, A. Watson, A. Ewans, A.B. Daniel, J. Rooney, K. Vitense, K. Wolf, A. Thomas, and C. Lalone. Weight of Evidence for Cross-Species Conservation of Androgen Receptor-Based Biological Activity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA" <br> Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25 <br>
DOI: 10.6084/m9.figshare.28171277.v1
title: Supplementary Material for: Symptom Reporting in Patients with Primary Biliary Cholangitis: Higher Burden of Symptoms detection using an interactive App

description: Introduction: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease causing bile duct destruction and inflammation, impacting patient quality of life (QoL) due to variable symptoms. Digital symptom-tracker apps may improve patient care through enhanced monitoring. This feasibility study reassessed symptom burden in PBC patients using a tailored symptom-tracker app, focusing on its usability, effectiveness, and impact on management and QoL.

Methods: Methods: Based on Kautz5 gUG "Symptomtracker", our app in REDCap allowed users to log PBC symptoms over four weeks, alongside medication use. Ethics approval and data security complied with German regulations. User feedback was incorporated for better usability. Symptom data were standardized, and R software was used for descriptive statistics and Chi-square tests. 

Results: From March 2023 to October 2024, 207 patients (184 female, 20 male) were enrolled, median age 51 years. Among 90 patients who completed the questionnaire, fatigue was most prevalent (87.8%), followed by joint pain (80%), concentration difficulties (74.4%), abdominal discomfort (70%), and sicca symptoms. Other common symptoms were leg cramps (50%) and swollen feet (40%); jaundice was rare (7.8%). Older patients, especially those aged 50–60, reported higher symptom burden, but Chi-square tests showed no significant differences across age or gender.

Conclusion: Our study highlights a significant symptom burden in PBC, particularly fatigue and joint pain. While older patients reported more symptoms, no significant differences were observed by age or gender. The symptom-tracker app enhanced monitoring and patient engagement, showing the potential of digital tools in PBC management. Further research is needed to evaluate long-term impacts.
DOI: 10.6084/m9.figshare.3842904.v1
title: Yorku. Woodlot. Sept20-2016.CVS

description: This study was conducted to measure the diameter at breast height (dbh) of adult trees in pairs and the distance between them in woodlots, at York University around 3:30pm- 5:00pm. Location: Data was collected at York University, at Keele St. and York Blvd, in the Woodlots. Methods: In this field experiment, transects measuring tapes were used to determine the distance between 10 pairs of sugar maple trees. The diameters were measured from the middle of the tree trunks, using a tape measure. Canopy coverage was determined by making square with fingers and holding it up, in order to gain an estimate regarding how much of the sky was seen. Key to variables: Diameter at breast height (dbh), distance to nearest species, and canopy coverage were continuous and quantitative variables. Prediction: It was predicted that the distance between two trees with a low dbh would be less than those with a greater dbh, since the smaller the dbh, the smaller the tree and therefore, the less branches and canopy coverage it would have. Thus, the space it occupies would be less and the trees could form closer to each other. Hypothesis: Tree pairs with lower dbh are closer to each other than pairs with greater dbh. Also canopy coverage is greater for trees with a higher dbh.
DOI: 10.6084/m9.figshare.7756688.v1
title: Underlying data

description: This MS Excel file has two excel sheets, one containing data and the second sheet containing codebook
DOI: 10.6084/m9.figshare.19574980.v1
title: Cyberbullying

description: A total of 777 middle school students (females = 336; mean age = 13.57; SD = 0.98) were investigated by using the Parent Attachment Questionnaire, Deviant Peer Affiliation Questionnaire, Moral Disengagement Questionnaire and Cyber Bullying Behavior Questionnaire.
DOI: 10.6084/m9.figshare.12240980.v1
title: microsoftdata_behaviors.xlsx

description: Behavioral annotations using the malware behavioral catalog as a taxonomy. The behaviors contain an overall objective and the techniques employed to meet that objective.<br><br>Sandia National Laboratories is a multimission laboratory managed and operated by National Technology \& Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525. SAND2020-5090 O<br>
DOI: 10.6084/m9.figshare.15046797.v3
title: Code and Data for Prediction of SARS-Cov-2-positivity from million-scale complete blood counts using machine learning

description: Sample data and code for easy reproducibility of results described in the paper<em> Prediction of SARS-CoV-2-positivity from million-scale complete blood counts using machine learning.</em> <br> Please see the paper for the full author list and more details. <br> https://www.nature.com/articles/s43856-022-00129-0<br>
DOI: 10.6084/m9.figshare.25551138.v1
title: Requisitos para la selección de software de gestión para bibliotecas y colecciones digitales patrimoniales

description: Este conjunto de datos recoge una recopilación de requisitos extraídos de la literatura científica, así como del análisis de las prestaciones de algunas de las aplicaciones más populares en diferentes sectores: DSpace-GLAM, Omeka Classic, Omeka S, Artefactual y ArchivesSpace. Se incluye también la lista de referencias utilizadas para el análisis. Todo este material forma parte del trabajo publicado como informe bajo el título: <i>A</i><i>nálisis de requisitos para la selección de software de gestión para bibliotecas y colecciones digitales patrimoniales</i>. Barcelona: Universitat de Barcelona.
DOI: 10.6084/m9.figshare.20289024.v1
title: Man Bac femur morphology, histology, and ancestry

description: Dataset for all variables describing and measuring femora in a Man Bac sample from Holocene Vietnam. The dataset includes data for femoral morphometry and cortical bone histomorphometry.
DOI: 10.6084/m9.figshare.10260035.v1
title: Supplementary Material for: Breastfeeding and Atopic Dermatitis Risk: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

description: <b><i>Objectives:</i></b> The effect of breastfeeding on atopic dermatitis (AD) remains controversial. To determine the association ­between breastfeeding and AD, we conducted an updated meta-analysis of prospective cohort studies. <b><i>Methods:</i></b> A comprehensive search of PubMed, EMBASE, MEDLINE and Cochrane Library was conducted. Studies meeting the predetermined criteria were evaluated by 2 authors independently. The pooled relative risk (RR) adjusted for confounders with its 95% CI was calculated by a random-effects model. Heterogeneity was explored by subgroup analysis and meta-regression. <b><i>Results:</i></b> A total of 27 studies were included for meta-analysis. The pooled estimates for the effect of total and exclusive breastfeeding on AD were 1.01 (95% CI 0.93–1.10) and 0.99 (95% CI 0.88–1.11), respectively. Heterogeneity was substantial across studies (total: <i>p</i> &lt; 0.01 or <i>I</i><sup>2</sup> = 65.2%; exclusive: <i>p</i> &lt; 0.01 or <i>I</i><sup>2</sup> = 72.3%). There was a weak evidence for a protective effect of breastfeeding against AD in cohorts with atopic heredity (total: RR 0.85, 95% CI 0.74–0.98; exclusive: RR 0.83, 95% CI 0.70–0.97). In cohorts without atopic heredity, the effect shifted to the risk side when limited to exclusive breastfeeding (RR 1.19, 95% CI 1.02–1.40) while it dropped towards null when limited to total breastfeeding (RR 1.11, 95% CI 0.94–1.31). <b><i>Conclusions:</i></b> There is no association between AD and breastfeeding, regardless of total or exclusive breastfeeding patterns. There is some evidence for a protective function of exclusive and total breastfeeding in a cohort with atopic heredity. The effect shifts to the risk side in cohorts without atopic heredity. However, these findings should be interpreted with caution because heterogeneity is evident.
DOI: 10.6084/m9.figshare.28722122.v1
title: Table_S3.rank_genes_tumor_cells.csv

description: <b>Table S3. </b>Differentially expressed genes (DEGs) between GL261, GL261-GSCs and implanted GL261-GSCs, as shown in Figure 3B and suppl. Figure 2 A.<br>
DOI: 10.6084/m9.figshare.7379930.v3
title: Phyloseq data products

description: Included here are the sequence and taxonomy tables as well as the fasta file before mitochondria and chloroplast ASVs were removed (12,479 ASVs). Also included are data for the three samples that were not part of the original analysis.--The taxonomy table (full_tax_table.txt) contains the complete SILVA lineage.--The sequence table (full_seq_table.txt) contains the raw read count for each ASV by sample.--The fasta file (full_ASV.fasta) contains all ASV sequences.Also included here are the same files after removing mitochondria and chloroplast ASVs (trim_tax_table.txt, trim_seq_table.txt, trim_ASV.fasta). <br>
DOI: 10.6084/m9.figshare.11967924.v1
title: Metadata record for: A global database of Holocene paleotemperature records

description: This dataset contains key characteristics about the data described in the Data Descriptor A global database of Holocene paleotemperature records. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.19849456.v1
title: Supplementary Material for: sFlt-1/PlGF ratio at 24 weeks gestation in twin pregnancies as a predictor of preeclampsia or fetal growth restriction

description: Objective: to elucidate if sFlt-1/PlGF ratio at 24 weeks in twin pregnancies could be useful to select patients who subsequently develop diseases related to placental dysfunction, such as preeclampsia or fetal growth restriction (FGR). Methods: prospective study among all twin pregnancies followed up at a tertiary Hospital. The sFlt-1/PlGF ratio was determined at 24 weeks. Results: a total of 108 patients with a twin gestation were included. Pregnant women who developed preeclampsia and/or FGR displayed a significantly higher sFlt-1/PlGF ratio at 24 weeks, compared to those who did not develop these diseases (20.3 vs 4.3, p=0.002). Mean sFlt-1/PlGF ratio was not significantly different between patients who subsequently developed preeclampsia compared with those that developed FGR (29.8 vs 18.45, p=0.42). An sFlt-1/PlGF ratio ≥17 at 24 weeks is associated with a significant increase in the frequency of preeclampsia (odds ratio, 37.13 [95% confidence interval, 4.78–288.25]; p=0.002), and FGR (odds ratio, 39.58 [95% confidence interval, 6.31–248.17]; p&lt;0.001). The addition of maternal characteristics, and mean pulsatility index of the uterine arteries to the sFlt-1/PlGF ratio at 24 weeks enhance the identification of patients who develop preeclampsia or FGR. Conclusion: sFlt-1/PlGF ratio at 24 weeks in twin pregnancies, combined with mean pulsatility index of the uterine arteries and maternal characteristics, could select patients who develop preeclampsia or FGR. These patients might benefit from a close follow-up in order to avoid maternal-fetal adverse outcomes.
DOI: 10.6084/m9.figshare.24803172.v1
title: Genotyping of multiple myeloma

description: Genotyping of multiple myeloma using targeted gene panel
DOI: 10.6084/m9.figshare.14983857.v4
title: Table S2 - Ecological Modeling Results

description: Table displaying the contribution of assembly processes towards assembly in individual wells and different well groupings.
DOI: 10.6084/m9.figshare.18393854.v1
title: A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis

description: We present here liver lipidomic data from eight-week old male C57BL/6N wild-type mice receving normal chow diet (NCD), high-fat diet (HFD) or a combination of high-fat diet treated with the S6K1 inhibitor LY2584702 tosylate (HFD+LY) during 10 weeks (4 animals/experimental condition). The analysis of lipids was performed by direct flow injection analysis (FIA) using either a triple quadrupole mass spectrometer (FIA-MS/MS; QQQ triple quadrupole) or a hybrid quadrupole-Orbitrap mass spectrometer (FIA-FTMS; high mass resolution). FIA-MS/MS (QQQ) was performed in positive ion mode using the analytical setup and strategy described previously (Höring et al.,2021; Höring et al., 2020; Höring et al., 2019)
DOI: 10.6084/m9.figshare.22059080.v1
title: Supplementary Material for: Coupled mutual inhibition and mutual activation motifs as tools for cell-fate control

description: Multistability is central to biological systems as it plays a crucial role in adaptation, evolvability, and differentiation. The presence of positive feedback loops can enable multistability. The simplest of such feedback loops are a) a mutual inhibition loop (MI), b) a mutual activation loop (MA), and c) self-activation, all three of them known to give rise to bistability. However, the characteristic differences in the bistability exhibited by these motifs are relatively less understood. Here, we use dynamical simulations across a large ensemble of parameter sets and initial conditions to study the bistability characteristics of these motifs. Furthermore, we investigate the utility of these motifs for achieving coordinated expression through cyclic and parallel coupling amongst them. Our analysis revealed that MI-based architectures offer discrete and robust control over gene expression, multistability, and coordinated expression among multiple genes, as compared to MA-based architectures. We then devised a combination of MI and MA architectures to improve coordination and multistability. Such designs help improve our understanding of the control structures involved in robust cell-fate decisions and provide a way to achieve controlled decision-making in synthetic systems.
DOI: 10.6084/m9.figshare.28633976.v1
title: Floral visitation data

description: The study was based on identifying flower-visiting insects under the family Syrphidae to supplement pollination services to European honey bees on cucurbits.
DOI: 10.6084/m9.figshare.834935.v8
title: Transitive Reduction of Citation Networks

description: Analysis of the Transitive Reduction of citations networks as a tool to reveal causal structure and highlight edges more likely to correspond to information transfer in a network. The paper can be found at http://arxiv.org/abs/1310.8224
DOI: 10.6084/m9.figshare.26490973.v1
title: HCPV Analysis files

description: HCPV Analysis files
DOI: 10.6084/m9.figshare.16794727.v1
title: Global ERA5 fuel moisture trends 1979 - 2019

description: Timeseries and Trend statistics (Sen-Theil slope estimates, Mann-Kendall S statistics, and associated Z statistics) for fine fuel moisture content (FMC) as calculated using the Canadian Forest Fire Weather Index (FWI) System and ERA5 data for the period 1979 to 2019. The underlying metrics use the FWI System's Fine Fuel Moisture Code (FFMC), transformed to a percentage of the fire season falling under 10% fuel moisture content, which has been identified as a critical threshold controlling fire potential. Also includes associated realm, biome, and ecoregion data using definitions from Olson et al. (2001).
DOI: 10.6084/m9.figshare.22817750.v2
title: Fish Stock Dynamics in the Baltic Sea Dataset 2015-2023

description: Fish Stock Dynamics in the Baltic Sea Dataset 2015-2023Excel file, TAC-SSB Figures, TAC-SSB Totals, Fish Stock History<br><br>