DOI: 10.5281/zenodo.17208971
title: SARS-CoV-2 RBD Mutation Constellations (G339D, S375F, E484A, Q493R, L452R): Insights from Historical Data on Monoclonal Antibody Class 3 Escape Risk Measured from 2021 - 2023 Data

description: This dataset contains historical sars-cov-2 sequences that present 5 mutation constellations each in a given sequence.

This may suggest that several mAbs are at risk of obsolesence which may or may not include Class-3 mAb

The representative mAbs that may or may not be affected by this specific constellation such as "G339D, S375F, E484A, Q493R, L452R" may or may not include S309 / Sotrovimab, REGN10987 (Imdevimab), LY-CoV1404 (Bebtelovimab), ADG-20 (Adintrevimab), BRII-196 / AZD1061 (Cilgavimab).

Further study may or may not suggest escape from these mAbs.

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PROGRESSIVE CONSTELLATION SUMMARY (G339D + S375F + E484A + Q493R + L452R)================================================================================

 FILE: constellation_1mut.csv--------------------------------------------------   Total unique sequences: 7,854,181   Top 10 sequences:     1. USA/CA-LACPHL-AF03923/2021        → Location: USA | Year: 2021 | Accession: 2021     2. USA/CA-CDC-FG-153775/2021        → Location: USA | Year: 2021 | Accession: 2021     3. USA/PA-BOL-M21128099/2021        → Location: USA | Year: 2021 | Accession: 2021     4. USA/CA-CDC-FG-153938/2021        → Location: USA | Year: 2021 | Accession: 2021     5. USA/FL-CDC-FG-023410/2021        → Location: USA | Year: 2021 | Accession: 2021     6. USA/MS-MSPHL-0575/2021        → Location: USA | Year: 2021 | Accession: 2021     7. USA/GA-GPHL-2326/2021        → Location: USA | Year: 2021 | Accession: 2021     8. USA/CEPH0000012663/2021        → Location: USA | Year: 2021 | Accession: 2021     9. USA/JW3282/2021        → Location: USA | Year: 2021 | Accession: 2021     10. USA/JW3304/2021        → Location: USA | Year: 2021 | Accession: 2021

FILE: constellation_2mut.csv--------------------------------------------------   Total unique sequences: 4,492,055   Top 10 sequences:     1. USA/CA-CDPH-3000263406/2021        → Location: USA | Year: 2021 | Accession: 2021     2. Switzerland/ZG-ETHZ-672463/2021        → Location: Switzerland | Year: 2021 | Accession: 2021     3. England/PLYM-2921E1F/2021        → Location: England | Year: 2021 | Accession: 2021     4. Switzerland/SZ-ETHZ-34518318/2021        → Location: Switzerland | Year: 2021 | Accession: 2021     5. Japan/SZ-NIG-Y222405/2022        → Location: Japan | Year: 2022 | Accession: 2022     6. Japan/SZ-NIG-Y222415/2022        → Location: Japan | Year: 2022 | Accession: 2022     7. USA/CA-CDPH-FS48099895/2022        → Location: USA | Year: 2022 | Accession: 2022     8. USA/CA-CDPH-FS48102929/2022        → Location: USA | Year: 2022 | Accession: 2022     9. USA/CA-CDPH-FS27887057/2022        → Location: USA | Year: 2022 | Accession: 2022     10. USA/CA-CDPH-FS25390299/2022        → Location: USA | Year: 2022 | Accession: 2022

 FILE: constellation_3mut.csv--------------------------------------------------   Total unique sequences: 3,835,494   Top 10 sequences:     1. Japan/SZ-NIG-Y222405/2022        → Location: Japan | Year: 2022 | Accession: 2022     2. Japan/SZ-NIG-Y222415/2022        → Location: Japan | Year: 2022 | Accession: 2022     3. USA/CA-CDPH-FS48099895/2022        → Location: USA | Year: 2022 | Accession: 2022     4. USA/CA-CDPH-FS48102929/2022        → Location: USA | Year: 2022 | Accession: 2022     5. USA/CA-CDPH-FS27887057/2022        → Location: USA | Year: 2022 | Accession: 2022     6. USA/CA-CDPH-FS25390299/2022        → Location: USA | Year: 2022 | Accession: 2022     7. USA/CA-CDPH-FS48101995/2022        → Location: USA | Year: 2022 | Accession: 2022     8. USA/CA-CDPH-FS48076159/2022        → Location: USA | Year: 2022 | Accession: 2022     9. USA/CA-CDPH-FS48102001/2022        → Location: USA | Year: 2022 | Accession: 2022     10. USA/CA-CDPH-FS48101831/2022        → Location: USA | Year: 2022 | Accession: 2022

FILE: constellation_4mut.csv--------------------------------------------------   Total unique sequences: 3,632,086   Top 10 sequences:     1. Japan/SZ-NIG-Y222405/2022        → Location: Japan | Year: 2022 | Accession: 2022     2. Japan/SZ-NIG-Y222415/2022        → Location: Japan | Year: 2022 | Accession: 2022     3. USA/CA-CDPH-FS48099895/2022        → Location: USA | Year: 2022 | Accession: 2022     4. USA/CA-CDPH-FS48102929/2022        → Location: USA | Year: 2022 | Accession: 2022     5. USA/CA-CDPH-FS27887057/2022        → Location: USA | Year: 2022 | Accession: 2022     6. USA/CA-CDPH-FS25390299/2022        → Location: USA | Year: 2022 | Accession: 2022     7. USA/CA-CDPH-FS48101995/2022        → Location: USA | Year: 2022 | Accession: 2022     8. USA/CA-CDPH-FS48076159/2022        → Location: USA | Year: 2022 | Accession: 2022     9. USA/CA-CDPH-FS48102001/2022        → Location: USA | Year: 2022 | Accession: 2022     10. USA/CA-CDPH-FS48101831/2022        → Location: USA | Year: 2022 | Accession: 2022

FILE: constellation_5mut.csv--------------------------------------------------   Total unique sequences: 3,056   Top 10 sequences:     1. USA/AL-CDC-STM-6H6GXAJ83/2022        → Location: USA | Year: 2022 | Accession: 2022     2. OY222177        → Location: Unknown | Year: Unknown | Accession: OY222177     3. NZL/22CH5172/2022        → Location: NZL | Year: 2022 | Accession: 2022     4. OZ188816        → Location: Unknown | Year: Unknown | Accession: OZ188816     5. KEN/SS5217/2021        → Location: KEN | Year: 2021 | Accession: 2021     6. USA/CA-CDC-FG-286379/2022        → Location: USA | Year: 2022 | Accession: 2022     7. OX906942        → Location: Unknown | Year: Unknown | Accession: OX906942     8. OY138144        → Location: Unknown | Year: Unknown | Accession: OY138144     9. England/ALDP-2EB3DE3/2021        → Location: England | Year: 2021 | Accession: 2021     10. England/LSPA-2FC7176/2021        → Location: England | Year: 2021 | Accession: 2021

Summary complete.

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