cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14039138
title: Triassic igneous activities in the east flank of the East Kunlun orogenic belt: the Daheba complex example

description: The Triassic igneous complexes in the east flank of the East Kunlun orogenic belt (E-KOB) provide a window through which to investigate the Mesozoic magmatism in the E-KOB. Here, we report the precise timing of Triassic magmatism and magma petrogenesis of different rock types in the east flank of the E-KOB based on the petrology, mineral chemistry, geochemistry, zircon geochronology and Lu-Hf isotopes. Zircon U-Pb dating reveals that the Daheba complex was crystallized in 242–239 Ma. The rocks display enrichment in large-ion lithophile elements (LILEs) and LREEs and depletion in high field strength elements (HFSEs) and HREEs, which are typical of subduction-related magmatic rocks. The fine-grained granites (FGs) are characterized by a high SiO<sub>2</sub> content (72.25–74.28 wt. %), a high differentiation index (DI = 95) and marked depletion in Sr, Ba and Eu, which indicates that the FGs are highly fractionated I-type granitoids. The zircon ε<sub>Hf</sub>(t) values from −3.6 to −1.1 with two-stage model ages (T<sub>DM2</sub>) of 1496–1340 Ma, which suggests that they were derived from an ancient Mesoproterozoic lower crust. The similarity in the REE patterns of the mafic microgranular enclaves (MMEs) and host granites (HGs) indicates that the mixing between mafic and felsic magmas could have contributed to the chemical variation of the MMEs. The mafic melts were derived from the partial melting of the mantle that had been metasomatized by slab-derived fluids. The MMEs show typical igneous textures, acicular apatites, sieve texture of plagioclase and reverse zoning of plagioclase, which correspond to magma mixing during petrogenesis. Our geochemical and isotopic data suggest that the Daheba complex formed in an active continental margin setting closely related to the northward subduction of the Palaeo-Tethys Ocean Plate beneath the E-KOB.
DOI: 10.6084/m9.figshare.4601950
title: Phylogenetic analysis among 27 Chinese populations and genetic polymorphisms of 20 autosomal STR loci in a Chinese Uyghur ethnic minority group

description: Allele frequency data and forensic statistical parameters were determined for 20 autosomal short tandem repeat (STR) loci of the PowerPlex 21 System in 214 unrelated healthy individuals of a Uyghur ethnic minority group living in Xinjiang province, northwest China. A total of 232 alleles were observed with the corresponding allele frequencies ranging from 0.0023 to 0.5304. All loci were consistent with Hardy–Weinberg equilibrium (HWE) after the Bonferroni correction (<i>p</i> &gt; 0.0025). The combined probability of exclusion, power of discrimination, probability of matching value were 0.999999999, 0.9999999999999999999999995, and 4.78246 × 10<sup>−25</sup>, respectively. Our results revealed that the 20 STRs were highly polymorphic and informative, and could be suitable for forensic application, especially parentage test and personal identification. The further population comparison between the Uyghur and other 26 reference populations revealed that the loci of D13S317, TH01 and D6S1043 showed high ethnical specificity. Phylogenetic analysis based on 19 shared loci demonstrated that the Uyghur had a close genetic relationship with the Kazakh, but a distinct genetic distance with other Chinese populations from different ethnicity and regions.
DOI: 10.6084/m9.figshare.14039138.v1
title: Triassic igneous activities in the east flank of the East Kunlun orogenic belt: the Daheba complex example

description: The Triassic igneous complexes in the east flank of the East Kunlun orogenic belt (E-KOB) provide a window through which to investigate the Mesozoic magmatism in the E-KOB. Here, we report the precise timing of Triassic magmatism and magma petrogenesis of different rock types in the east flank of the E-KOB based on the petrology, mineral chemistry, geochemistry, zircon geochronology and Lu-Hf isotopes. Zircon U-Pb dating reveals that the Daheba complex was crystallized in 242–239 Ma. The rocks display enrichment in large-ion lithophile elements (LILEs) and LREEs and depletion in high field strength elements (HFSEs) and HREEs, which are typical of subduction-related magmatic rocks. The fine-grained granites (FGs) are characterized by a high SiO<sub>2</sub> content (72.25–74.28 wt. %), a high differentiation index (DI = 95) and marked depletion in Sr, Ba and Eu, which indicates that the FGs are highly fractionated I-type granitoids. The zircon ε<sub>Hf</sub>(t) values from −3.6 to −1.1 with two-stage model ages (T<sub>DM2</sub>) of 1496–1340 Ma, which suggests that they were derived from an ancient Mesoproterozoic lower crust. The similarity in the REE patterns of the mafic microgranular enclaves (MMEs) and host granites (HGs) indicates that the mixing between mafic and felsic magmas could have contributed to the chemical variation of the MMEs. The mafic melts were derived from the partial melting of the mantle that had been metasomatized by slab-derived fluids. The MMEs show typical igneous textures, acicular apatites, sieve texture of plagioclase and reverse zoning of plagioclase, which correspond to magma mixing during petrogenesis. Our geochemical and isotopic data suggest that the Daheba complex formed in an active continental margin setting closely related to the northward subduction of the Palaeo-Tethys Ocean Plate beneath the E-KOB.
DOI: 10.3886/e198564
title: Foltyn and Olsson (2024)

description: PSID extract used for the paper ``Subjective Life Expectancies, Time Preference Heterogeneity, and Wealth Inequality.'' <br>
DOI: 10.3886/e198564v1
title: Foltyn and Olsson (2024)

description: PSID extract used for the paper ``Subjective Life Expectancies, Time Preference Heterogeneity, and Wealth Inequality.'' <br>
DOI: 10.6084/m9.figshare.20330587
title: Molecular dynamics simulations of the SARS-CoV-2 Spike protein and variants of concern: structural evidence for convergent adaptive evolution

description: The Spike protein's structure of the SARS-CoV-2 provides a unique opportunity to consider perturbations at the atomic level. We used the cryo-electron microscopy structure of the open conformation of the Spike protein to assess the impact of the mutations observed in the variants of concern at the molecular level. Molecular dynamics were subsequently performed with both the wt and the mutated forms to compare the flexibility and variation data for each residue of the three-dimensional fluctuations in the region associated with each alpha carbon. Additionally, protein-protein docking was used to investigate the interaction of each mutated profile with the ACE-2 receptor. After the molecular dynamics, the results show that the mutations increased the stability of the trimeric protein, with greater stability observed in the Gamma variant harboring the 10 characteristic mutations. The results of molecular dynamics, as shown by RMSF demonstrated for the residues that comprise the binding domain receptor (RBD), exhibited a reduction in flexibility, which was more pronounced in the Gamma variant. Finally, protein-protein docking experiments revealed an increase in the number of hydrophobic interactions and hydrogen bonds in the Gamma variant against the ACE-2 receptor, as opposed to the other variants. Taken together, these <i>in silico</i> experiments suggest that the evolution of the mutations favored the increased stability of Spike protein while potentially improving its interaction with the ACE-2 receptor, which in turn may indicate putative structural outcomes of the selection of these mutations in the convergent adaptive evolution as it has been observed for SARS-CoV-2. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.20330587.v1
title: Molecular dynamics simulations of the SARS-CoV-2 Spike protein and variants of concern: structural evidence for convergent adaptive evolution

description: The Spike protein's structure of the SARS-CoV-2 provides a unique opportunity to consider perturbations at the atomic level. We used the cryo-electron microscopy structure of the open conformation of the Spike protein to assess the impact of the mutations observed in the variants of concern at the molecular level. Molecular dynamics were subsequently performed with both the wt and the mutated forms to compare the flexibility and variation data for each residue of the three-dimensional fluctuations in the region associated with each alpha carbon. Additionally, protein-protein docking was used to investigate the interaction of each mutated profile with the ACE-2 receptor. After the molecular dynamics, the results show that the mutations increased the stability of the trimeric protein, with greater stability observed in the Gamma variant harboring the 10 characteristic mutations. The results of molecular dynamics, as shown by RMSF demonstrated for the residues that comprise the binding domain receptor (RBD), exhibited a reduction in flexibility, which was more pronounced in the Gamma variant. Finally, protein-protein docking experiments revealed an increase in the number of hydrophobic interactions and hydrogen bonds in the Gamma variant against the ACE-2 receptor, as opposed to the other variants. Taken together, these <i>in silico</i> experiments suggest that the evolution of the mutations favored the increased stability of Spike protein while potentially improving its interaction with the ACE-2 receptor, which in turn may indicate putative structural outcomes of the selection of these mutations in the convergent adaptive evolution as it has been observed for SARS-CoV-2. Communicated by Ramaswamy H. Sarma
DOI: 10.6084/m9.figshare.7581311
title: Additional file 1: of Correlate tumor mutation burden with immune signatures in human cancers

description: Table S1. Comparison of regulatory T cell marker genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S2. Comparison of immune checkpoint genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S3. Comparison of immune cell infiltrate genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S4. Comparison of tumor-infiltrating lymphocytes genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S5. Comparison of cancer-testis antigen genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S6. Comparison of HLA genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S7. Comparison of cytokine and cytokine receptor genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S8. Comparison of pro-inflammation genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. (XLSX 130 kb)
DOI: 10.6084/m9.figshare.22952403.v1
title: Isoalantolactone mediates the degradation of BCR-ABL protein in imatinib-resistant CML cells by down-regulating survivin

description: Isoalantolactone (Iso) is a bioactive lactone isolated from the root of Inula helenium L, which has been reported to have many pharmacological effects. To investigate the role and mechanism of isoalantolactone in chronic myeloid leukemia (CML), we first investigated isoalantolactone’s anti-proliferative effects on imatinib-sensitive and imatinib-resistant CML cells by CCK8. Flow cytometry was used to detect isoalantolactone-induced cell apoptosis. Survivin was overexpressed in KBM5 and KBM5<sup>T315I</sup> cells using the lentivirus vector pSIN-3×flag-PURO. In KBM5 and KBM5<sup>T315I</sup> cells, shRNA was used to knockdown survivin. Cellular Thermal Shift Assay (CETSA) was used to detect the interaction between isoalantolactone and survivin. The ubiquitin of survivin induced by isoalantolactone was detected through immunoprecipitation. Quantitative polymerase-chain reaction (Q-PCR) and western blotting were used to detect the levels of mRNA and protein. Isoalantolactone inhibits the proliferation and promotes apoptosis of imatinib-resistant CML cells. Although isoalantolactone inhibits the proteins of BCR-ABL and survivin, it cannot inhibit survivin and BCR-ABL mRNA levels. Simultaneously, it was shown that isoalantolactone can degrade survivin protein by increasing ubiquitination. It was demonstrated that isoalantolactone-induced survivin mediated downregulation of BCR-ABL protein. It was also revealed that isoalantolactone triggered BCR-ABL protein degradation via caspase-3. Altogether, isoalantolactone inhibits survivin through the ubiquitin proteasome pathway, and mediates BCR-ABL downregulation in a caspase-3 dependent manner. These data suggest that isoalantolactone is a natural compound, which can be used as a potential drug to treat TKI-resistant CML.
DOI: 10.6084/m9.figshare.22952403
title: Isoalantolactone mediates the degradation of BCR-ABL protein in imatinib-resistant CML cells by down-regulating survivin

description: Isoalantolactone (Iso) is a bioactive lactone isolated from the root of Inula helenium L, which has been reported to have many pharmacological effects. To investigate the role and mechanism of isoalantolactone in chronic myeloid leukemia (CML), we first investigated isoalantolactone’s anti-proliferative effects on imatinib-sensitive and imatinib-resistant CML cells by CCK8. Flow cytometry was used to detect isoalantolactone-induced cell apoptosis. Survivin was overexpressed in KBM5 and KBM5<sup>T315I</sup> cells using the lentivirus vector pSIN-3×flag-PURO. In KBM5 and KBM5<sup>T315I</sup> cells, shRNA was used to knockdown survivin. Cellular Thermal Shift Assay (CETSA) was used to detect the interaction between isoalantolactone and survivin. The ubiquitin of survivin induced by isoalantolactone was detected through immunoprecipitation. Quantitative polymerase-chain reaction (Q-PCR) and western blotting were used to detect the levels of mRNA and protein. Isoalantolactone inhibits the proliferation and promotes apoptosis of imatinib-resistant CML cells. Although isoalantolactone inhibits the proteins of BCR-ABL and survivin, it cannot inhibit survivin and BCR-ABL mRNA levels. Simultaneously, it was shown that isoalantolactone can degrade survivin protein by increasing ubiquitination. It was demonstrated that isoalantolactone-induced survivin mediated downregulation of BCR-ABL protein. It was also revealed that isoalantolactone triggered BCR-ABL protein degradation via caspase-3. Altogether, isoalantolactone inhibits survivin through the ubiquitin proteasome pathway, and mediates BCR-ABL downregulation in a caspase-3 dependent manner. These data suggest that isoalantolactone is a natural compound, which can be used as a potential drug to treat TKI-resistant CML.
DOI: 10.6084/m9.figshare.7581311.v1
title: Additional file 1: of Correlate tumor mutation burden with immune signatures in human cancers

description: Table S1. Comparison of regulatory T cell marker genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S2. Comparison of immune checkpoint genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S3. Comparison of immune cell infiltrate genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S4. Comparison of tumor-infiltrating lymphocytes genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S5. Comparison of cancer-testis antigen genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S6. Comparison of HLA genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S7. Comparison of cytokine and cytokine receptor genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. Table S8. Comparison of pro-inflammation genes expression levels between the lower-TMB and the higher-TMB subtypes of cancers. (XLSX 130 kb)
DOI: 10.6084/m9.figshare.11418315
title: Pig as a reservoir of CRISPR type TST4 <i>Salmonella enterica</i> serovar Typhimurium monophasic variant during 2009–2017 in China

description: CRISPR-based typing was performed to subtype isolates of <i>S.</i> Typhimurium and its monophasic variant <i>Salmonella</i> 4,[5],12:i:- from humans and animals between 2009 and 2017 in China. CRISPR typing classified all isolates into two lineages and four sub-lineages. All isolates from Lineage II and Lineage IB-1 were <i>Salmonella</i> Typhimurium. All of <i>Salmonella</i> 4,[5],12:i: – isolates were distributed in Lineage IA and Lineage IB-2, which all belonged to ST34 by MLST typing. Only Lineage IB-2 contained ST34 isolates from both <i>Salmonella</i> Typhimurium and <i>Salmonella</i> 4,[5],12:i:-. Among the isolates of ST34, TST4 was identified as the most common CRISPR type representing 86.5% of <i>Salmonella</i> 4,[5],12:i:- and 14.5 % of <i>Salmonella</i> Typhimurium mainly from pigs and humans. This study demonstrated that TST4-ST34 isolates were predominant in <i>Salmonella</i> 4,[5],12:i:-, and pig was the main reservoir for <i>Salmonella</i> 4,[5],12:i:- in China, which might have the potential to transmit to humans by pig production.
DOI: 10.6084/m9.figshare.11418315.v1
title: Pig as a reservoir of CRISPR type TST4 <i>Salmonella enterica</i> serovar Typhimurium monophasic variant during 2009–2017 in China

description: CRISPR-based typing was performed to subtype isolates of <i>S.</i> Typhimurium and its monophasic variant <i>Salmonella</i> 4,[5],12:i:- from humans and animals between 2009 and 2017 in China. CRISPR typing classified all isolates into two lineages and four sub-lineages. All isolates from Lineage II and Lineage IB-1 were <i>Salmonella</i> Typhimurium. All of <i>Salmonella</i> 4,[5],12:i: – isolates were distributed in Lineage IA and Lineage IB-2, which all belonged to ST34 by MLST typing. Only Lineage IB-2 contained ST34 isolates from both <i>Salmonella</i> Typhimurium and <i>Salmonella</i> 4,[5],12:i:-. Among the isolates of ST34, TST4 was identified as the most common CRISPR type representing 86.5% of <i>Salmonella</i> 4,[5],12:i:- and 14.5 % of <i>Salmonella</i> Typhimurium mainly from pigs and humans. This study demonstrated that TST4-ST34 isolates were predominant in <i>Salmonella</i> 4,[5],12:i:-, and pig was the main reservoir for <i>Salmonella</i> 4,[5],12:i:- in China, which might have the potential to transmit to humans by pig production.
DOI: 10.6084/m9.figshare.16661210
title: Sodium glucose cotransporter 2 inhibitor dapagliflozin depressed adiposity and ameliorated hepatic steatosis in high-fat diet induced obese mice

description: With the increasing obesity prevalence, the rates of obesity-related diseases, including type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases, have increased dramatically. Dapagliflozin, one of the sodium glucose cotransporter inhibitors, not only exerts hypoglycaemic effects through increasing urinary glucose excretion but alsoreprograms the metabolic system, leading to benefits in metabolic and cardiovascular diseases. In this study, pre-established obese mice on a high-fat diet were given dapagliflozin by gavage for fourweeks. It showed that dapagliflozin can enhance fat utilization and browning of adipose tissue and improve local oxidative stress, thus inhibiting fat accumulation and hepatic steatosis without disturbance in body weight or plasma glycolipid level. Overall, our study highlights the potential clinical application of SGLT2 inhibition in the prevention of obesity and related metabolic diseases, such as insulin resistance, NAFLD, and diabetes.
DOI: 10.6084/m9.figshare.16661210.v2
title: Sodium glucose cotransporter 2 inhibitor dapagliflozin depressed adiposity and ameliorated hepatic steatosis in high-fat diet induced obese mice

description: With the increasing obesity prevalence, the rates of obesity-related diseases, including type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases, have increased dramatically. Dapagliflozin, one of the sodium glucose cotransporter inhibitors, not only exerts hypoglycaemic effects through increasing urinary glucose excretion but alsoreprograms the metabolic system, leading to benefits in metabolic and cardiovascular diseases. In this study, pre-established obese mice on a high-fat diet were given dapagliflozin by gavage for fourweeks. It showed that dapagliflozin can enhance fat utilization and browning of adipose tissue and improve local oxidative stress, thus inhibiting fat accumulation and hepatic steatosis without disturbance in body weight or plasma glycolipid level. Overall, our study highlights the potential clinical application of SGLT2 inhibition in the prevention of obesity and related metabolic diseases, such as insulin resistance, NAFLD, and diabetes.
DOI: 10.6084/m9.figshare.16661210.v1
title: Sodium glucose cotransporter 2 inhibitor dapagliflozin depressed adiposity and ameliorated hepatic steatosis in high-fat diet induced obese mice

description: With the increasing obesity prevalence, the rates of obesity-related diseases, including type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases, have increased dramatically. Dapagliflozin, one of the sodium glucose cotransporter inhibitors, not only exerts hypoglycaemic effects through increasing urinary glucose excretion but alsoreprograms the metabolic system, leading to benefits in metabolic and cardiovascular diseases. In this study, pre-established obese mice on a high-fat diet were given dapagliflozin by gavage for fourweeks. It showed that dapagliflozin can enhance fat utilization and browning of adipose tissue and improve local oxidative stress, thus inhibiting fat accumulation and hepatic steatosis without disturbance in body weight or plasma glycolipid level. Overall, our study highlights the potential clinical application of SGLT2 inhibition in the prevention of obesity and related metabolic diseases, such as insulin resistance, NAFLD, and diabetes.
DOI: 10.6084/m9.figshare.25273249
title: Tabla 3. Características de contenido y forma de la intervención

description: El objetivo de este artículo fue sistematizar los diseños, tipos de resultados y características de las intervenciones a la violencia digital que existen a nivel internacional en contextos escolares, con la finalidad de realizar una comparación meta analítica que permita recuperar las mejores prácticas, por lo que en esta Tabla se describen las características de contenido y forma de 25 estudios que evaluaron programas de intervención a la ciberviolencia.
DOI: 10.6084/m9.figshare.25273249.v1
title: Tabla 3. Características de contenido y forma de la intervención

description: El objetivo de este artículo fue sistematizar los diseños, tipos de resultados y características de las intervenciones a la violencia digital que existen a nivel internacional en contextos escolares, con la finalidad de realizar una comparación meta analítica que permita recuperar las mejores prácticas, por lo que en esta Tabla se describen las características de contenido y forma de 25 estudios que evaluaron programas de intervención a la ciberviolencia.
DOI: 10.6084/m9.figshare.25273174
title: TAE - Two waves dataset.sav

description: TAE - Two waves dataset.sav
DOI: 10.6084/m9.figshare.25273174.v1
title: TAE - Two waves dataset.sav

description: TAE - Two waves dataset.sav