cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29716000
title: Gut microbiota and circadian disruption in humans: Is there a rationale for metabolic disorders?

description: Circadian disruption, arising from behaviors such as shift work and sleep deprivation, is increasingly prevalent and associated with metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. The gut microbiome plays a crucial role in metabolic homeostasis by producing metabolites – such as short-chain fatty acids, secondary bile acids, and microbial-associated molecular patterns – that influence nutrient absorption, immune responses, and host metabolism in alignment with circadian rhythms. This review explores how circadian disruptors influence the human gut microbiome, focusing on changes in microbial composition, diversity, and functionality, and their implications for metabolic health. Preclinical studies demonstrate that circadian disruptions alter microbial composition, reduce rhythmicity, and impair functionality, contributing to metabolic disorders. However, human studies often report inconsistent findings, with microbial functionality appearing more sensitive to disruptions than composition. Eating patterns affect both the gut microbiome and circadian alignment; their optimization could realign microbial and host rhythms to promote metabolic homeostasis. Future research should focus on longitudinal and interventional studies using advanced methodologies, such as real-time intestinal gas measurements, to capture dynamic microbial activity in humans. Understanding microbial responses to circadian disruptors could inform therapeutic strategies targeting host-microbe interactions to improve metabolic health.
DOI: 10.6084/m9.figshare.29716000.v1
title: Gut microbiota and circadian disruption in humans: Is there a rationale for metabolic disorders?

description: Circadian disruption, arising from behaviors such as shift work and sleep deprivation, is increasingly prevalent and associated with metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. The gut microbiome plays a crucial role in metabolic homeostasis by producing metabolites – such as short-chain fatty acids, secondary bile acids, and microbial-associated molecular patterns – that influence nutrient absorption, immune responses, and host metabolism in alignment with circadian rhythms. This review explores how circadian disruptors influence the human gut microbiome, focusing on changes in microbial composition, diversity, and functionality, and their implications for metabolic health. Preclinical studies demonstrate that circadian disruptions alter microbial composition, reduce rhythmicity, and impair functionality, contributing to metabolic disorders. However, human studies often report inconsistent findings, with microbial functionality appearing more sensitive to disruptions than composition. Eating patterns affect both the gut microbiome and circadian alignment; their optimization could realign microbial and host rhythms to promote metabolic homeostasis. Future research should focus on longitudinal and interventional studies using advanced methodologies, such as real-time intestinal gas measurements, to capture dynamic microbial activity in humans. Understanding microbial responses to circadian disruptors could inform therapeutic strategies targeting host-microbe interactions to improve metabolic health.
DOI: 10.15468/dl.8jtgn4
title: Occurrence Download

description: A dataset containing 274 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Achnanthes minutissima",
 "Geometry POLYGON((119.300000 20.500000, 122.100000 20.500000, 122.100000 25.400000, 119.300000 25.400000, 119.300000 20.500000))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 274 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029142-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30231582
title: Clinician-developed modifiable script to support informational counselling during real-ear measurements

description: The purpose of this study was to have experienced audiologists identify the key ideas to convey to clients about real-ear measurement (REM) verification and create a modifiable script to use for REM informational counselling. A modified concept mapping design was used. Seventeen experienced audiologists participated in one or more research activities: brainstorming individual counselling statements; rating statements on importance and feasibility; and discussing in a focus group how the statements can be used in a counselling script. Brainstorming generated 227 statements. Researchers cleaned, combined, and recirculated the statements to participants for further ideas, resulting in 136 statements for sorting and rating. Sorting yielded eight categories: Other uses of the hearing aid (HA) test system (11 statements); Purpose of REM (24 statements); Description of procedure (14 statements); Personalisation of hearing aids (14 statements); Setting expectations (21 statements); Speech map stimulus levels (17 statements); Client preparation (19 statements); and On-screen orientation (16 statements). After rating and discussion in the focus group, the final script included 57 statements. This study identified the key ideas to convey during REM informational counselling and produced a modifiable script that individuals can use when conducting REM.
DOI: 10.6084/m9.figshare.30231582.v1
title: Clinician-developed modifiable script to support informational counselling during real-ear measurements

description: The purpose of this study was to have experienced audiologists identify the key ideas to convey to clients about real-ear measurement (REM) verification and create a modifiable script to use for REM informational counselling. A modified concept mapping design was used. Seventeen experienced audiologists participated in one or more research activities: brainstorming individual counselling statements; rating statements on importance and feasibility; and discussing in a focus group how the statements can be used in a counselling script. Brainstorming generated 227 statements. Researchers cleaned, combined, and recirculated the statements to participants for further ideas, resulting in 136 statements for sorting and rating. Sorting yielded eight categories: Other uses of the hearing aid (HA) test system (11 statements); Purpose of REM (24 statements); Description of procedure (14 statements); Personalisation of hearing aids (14 statements); Setting expectations (21 statements); Speech map stimulus levels (17 statements); Client preparation (19 statements); and On-screen orientation (16 statements). After rating and discussion in the focus group, the final script included 57 statements. This study identified the key ideas to convey during REM informational counselling and produced a modifiable script that individuals can use when conducting REM.
DOI: 10.6084/m9.figshare.29114095
title: Interventions promoting remyelination in multiple sclerosis: a systematic review of clinical trials

description: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal damage. Current therapies primarily manage symptoms and slow disease progression but do not achieve remyelination. This systematic review evaluates the efficacy and safety of remyelination-promoting interventions in MS, focusing on clinical trials utilizing outcome measures validated in prior studies as indicators of remyelination. A comprehensive search of PubMed, Embase, Web of Science, and Cochrane Library was conducted in May 2024. Clinical trials assessing interventions with potential remyelinating properties were included. Data extraction followed standardized forms, and study quality was evaluated using ROBINS-I for non-randomized trials and RoB 2.0 for RCTs. Remyelination was assessed using Magnetization Transfer Ratio (MTR), Visual Evoked Potentials (VEPs), Myelin Water Fraction (MWF), Diffusion Tensor Imaging (DTI), and Optical Coherence Tomography (OCT). From 1,615 screened records, 25 studies met the inclusion criteria and were analyzed. Across the 3341 participants, 17 interventions were evaluated. Most studies demonstrated a moderate risk of bias, yet all interventions, except one, were generally safe and well tolerated. Notably, rHIgM22, L-T3, opicinumab, clemastine fumarate, phenonytoin, domperidone, GSK239512, human fetal neural precursor cells (hfNPCs), and low-intensity repetitive transcranial magnetic stimulation (LI-rTMS) exhibited remyelination potential. Additionally, disease-modifying therapies (DMTs) such as Ocrelizumab, Fingolimod, and Natalizumab showed promising effects. Although several interventions demonstrated remyelination potential, limitations such as small sample sizes, short follow-up periods, and lack of standardized clinical endpoints validating remyelination’s functional impact, highlight the need for robust clinical trial designs, advanced biomarkers, and combination therapies integrating remyelination, neuroprotection, and immunomodulation to improve MS treatment outcomes.
DOI: 10.6084/m9.figshare.29114095.v1
title: Interventions promoting remyelination in multiple sclerosis: a systematic review of clinical trials

description: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal damage. Current therapies primarily manage symptoms and slow disease progression but do not achieve remyelination. This systematic review evaluates the efficacy and safety of remyelination-promoting interventions in MS, focusing on clinical trials utilizing outcome measures validated in prior studies as indicators of remyelination. A comprehensive search of PubMed, Embase, Web of Science, and Cochrane Library was conducted in May 2024. Clinical trials assessing interventions with potential remyelinating properties were included. Data extraction followed standardized forms, and study quality was evaluated using ROBINS-I for non-randomized trials and RoB 2.0 for RCTs. Remyelination was assessed using Magnetization Transfer Ratio (MTR), Visual Evoked Potentials (VEPs), Myelin Water Fraction (MWF), Diffusion Tensor Imaging (DTI), and Optical Coherence Tomography (OCT). From 1,615 screened records, 25 studies met the inclusion criteria and were analyzed. Across the 3341 participants, 17 interventions were evaluated. Most studies demonstrated a moderate risk of bias, yet all interventions, except one, were generally safe and well tolerated. Notably, rHIgM22, L-T3, opicinumab, clemastine fumarate, phenonytoin, domperidone, GSK239512, human fetal neural precursor cells (hfNPCs), and low-intensity repetitive transcranial magnetic stimulation (LI-rTMS) exhibited remyelination potential. Additionally, disease-modifying therapies (DMTs) such as Ocrelizumab, Fingolimod, and Natalizumab showed promising effects. Although several interventions demonstrated remyelination potential, limitations such as small sample sizes, short follow-up periods, and lack of standardized clinical endpoints validating remyelination’s functional impact, highlight the need for robust clinical trial designs, advanced biomarkers, and combination therapies integrating remyelination, neuroprotection, and immunomodulation to improve MS treatment outcomes.
DOI: 10.6084/m9.figshare.29126810
title: Pursuing the impact of headaches in patients with idiopathic intracranial hypertension: a prospective cohort study

description: Persistent headaches have been reported in a significant percentage of patients with idiopathic intracranial hypertension (IIH). This study aimed to evaluate possible factors underlying post-IIH headache. IIH patients were evaluated for demographic and clinical features, along with the Headache Impact Test (HIT-6) and Migraine Disability Assessment Scale (MIDAS) questionnaires to assess headache-related impact and disability. Features noted at the initial visit were compared with those at follow-up after resolution of papilledema. Of the 91 patients included, 92.3% reported headaches at the initial visit, with 73.8% having headaches consistent with migraine. After resolution of papilledema, 54.9% continued to report headaches. Median HIT-6 and MIDAS scores at follow-up were significantly lower than at the first visit (<i>p</i> &lt; 0.001 for both). On univariate regression analysis, none of the demographic or clinical features investigated, including CSF opening pressure, were associated with post-resolution headaches (<i>p</i> &gt; 0.05). Higher HIT-6 and MIDAS scores at the first visit were associated with higher scores at follow-up (<i>p</i> &lt; 0.05). Cerebrospinal fluid opening pressure was not linked to the presence or impact of post-resolution headaches (<i>p</i> &gt; 0.05). Prior to IIH, 73.6% of patients reported headaches, with 73.1% of these consistent with migraine. Prior migraine was associated with higher HIT-6 and MIDAS scores at the initial visit (<i>p</i> = 0.02 and <i>p</i> &lt; 0.001, respectively). Migraine headaches before IIH diagnosis are associated with more severe and disabling headaches initially. Higher initial HIT-6 or MIDAS scores predict increased disability post-resolution. Headache-specific treatments should be further explored in patients with IIH.
DOI: 10.6084/m9.figshare.29126810.v1
title: Pursuing the impact of headaches in patients with idiopathic intracranial hypertension: a prospective cohort study

description: Persistent headaches have been reported in a significant percentage of patients with idiopathic intracranial hypertension (IIH). This study aimed to evaluate possible factors underlying post-IIH headache. IIH patients were evaluated for demographic and clinical features, along with the Headache Impact Test (HIT-6) and Migraine Disability Assessment Scale (MIDAS) questionnaires to assess headache-related impact and disability. Features noted at the initial visit were compared with those at follow-up after resolution of papilledema. Of the 91 patients included, 92.3% reported headaches at the initial visit, with 73.8% having headaches consistent with migraine. After resolution of papilledema, 54.9% continued to report headaches. Median HIT-6 and MIDAS scores at follow-up were significantly lower than at the first visit (<i>p</i> &lt; 0.001 for both). On univariate regression analysis, none of the demographic or clinical features investigated, including CSF opening pressure, were associated with post-resolution headaches (<i>p</i> &gt; 0.05). Higher HIT-6 and MIDAS scores at the first visit were associated with higher scores at follow-up (<i>p</i> &lt; 0.05). Cerebrospinal fluid opening pressure was not linked to the presence or impact of post-resolution headaches (<i>p</i> &gt; 0.05). Prior to IIH, 73.6% of patients reported headaches, with 73.1% of these consistent with migraine. Prior migraine was associated with higher HIT-6 and MIDAS scores at the initial visit (<i>p</i> = 0.02 and <i>p</i> &lt; 0.001, respectively). Migraine headaches before IIH diagnosis are associated with more severe and disabling headaches initially. Higher initial HIT-6 or MIDAS scores predict increased disability post-resolution. Headache-specific treatments should be further explored in patients with IIH.
DOI: 10.15468/dl.hvme66
title: Occurrence Download

description: A dataset containing 186 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is one of (Curcuma aromatica)"
 ]
}

 The dataset includes 186 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029143-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mxkh9q
title: Occurrence Download

description: A dataset containing 1771 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Heleia wallacei",
 "Country is one of (Brunei Darussalam, Indonesia, Philippines, Timor-Leste, Singapore)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1771 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029144-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4j7hrz
title: Occurrence Download

description: A dataset containing 649417 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "OccurrenceStatus is Present",
 "TaxonKey is Ulmus",
 "Year 1000-2025"
 ]
}

 The dataset includes 649417 records from 2357 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029083-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6yvllj
title: Occurrence Download

description: A dataset containing 398 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-79.80003 -25.92514,-30.19997 -25.92514,-30.19997 -6.07486,-79.80003 -6.07486,-79.80003 -25.92514))",
 "HasCoordinate is true",
 "TaxonKey is Alipiopsitta xanthops (Spix, 1824)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 398 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008257-180412121330197/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gn4a2n
title: Occurrence Download

description: A dataset containing 423 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Trachinotus paitensis Cuvier, 1832)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 423 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058159-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wg3g01
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-58.05176 -33.72434,-47.3291 -33.72434,-47.3291 -26.3525,-58.05176 -26.3525,-58.05176 -33.72434))",
 "HasCoordinate is true",
 "TaxonKey is Pittosporum undulatum Vent.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 15 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007669-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wcc4wg
title: Occurrence Download

description: A dataset containing 386442 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Material sample",
 "BasisOfRecord is Specimen"
 ]
 },
 "Continent is South America",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 {
 "or" : [
 "PublishingOrg is 2a7e3080-28a9-11dd-97cd-b8a03c50a862",
 "PublishingOrg is 8edbbde0-055e-11d8-b850-b8a03c50a862",
 "PublishingOrg is 6ea87510-0561-11d8-b851-b8a03c50a862",
 "PublishingOrg is bc092ff0-02e4-11dc-991f-b8a03c50a862"
 ]
 },
 "TaxonKey is Animalia"
 ]
}

 The dataset includes 386442 records from 147 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0054645-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wdxywd
title: Occurrence Download

description: A dataset containing 6529 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dinoponera quadriceps Kempf, 1971"
 ]
}

 The dataset includes 6529 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053741-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9a56ua
title: Occurrence Download

description: A dataset containing 14788 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Anartia jatrophae (Linnaeus, 1763)"
 ]
}

 The dataset includes 14788 records from 95 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019294-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.q95dnu
title: Occurrence Download

description: A dataset containing 16946 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "MULTIPOLYGON(((5.241862535476685 43.294803095683314,5.241862535476685 43.25493380778211,5.340739488601685 43.25493380778211,5.340739488601685 43.294803095683314,5.241862535476685 43.294803095683314)))"
 ]
}

 The dataset includes 16946 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0084738-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yg27em
title: Occurrence Download

description: A dataset containing 884 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lamna nasus (Bonnaterre, 1788)"
 ]
}

 The dataset includes 884 records from 83 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053745-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nrr9z3
title: Occurrence Download

description: A dataset containing 158 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Hong Kong",
 "Country is Chinese Taipei",
 "Country is China"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Prosopocoilus Westwood, 1845"
 ]
}

 The dataset includes 158 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019301-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bmalt6
title: Occurrence Download

description: A dataset containing 176 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Chile",
 "Country is Argentina"
 ]
 },
 "TaxonKey is Myrceugenia planipes (Hook. & Arn.) O.Berg"
 ]
}

 The dataset includes 176 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008258-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.su7rey
title: Occurrence Download

description: A dataset containing 456 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Canada",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Ribes rubrum L."
 ]
}

 The dataset includes 456 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0390424-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.