cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6069/by50-8v15
title: A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxyacids

description: Modular polyketide synthases (PKSs) have been proposed as promising megasynthases for retrobiosynthesis because of their fitness for rational carbon skeleton design. However, over the last three decades, all engineered PKSs produce carboxylic acids via terminal thioesterase (TE), which significantly narrows available chemical scope. We proposed the possibility of expanding PKS chemical diversity via terminal thioreductase (TR) engineering, and comprehensively characterised PKS TRs as NADPH-dependent enzymes to terminate polyketides with aldehyde. These aldehyde products can be readily converted to industrially valuable alcohols and amines, demonstrated by an engineered rimocidin PKS-TR producing 1,3-butanediol, 1,3-pentanediol, and 1,3-hexanediol with a total titer of 1008 mg/L in Streptomyces albus,  or producing 554 mg/L 1-amino-3-alcohols via post-PKS transamination, both in shake flasks. Furthermore, efficient control of the product profile was achieved by coenzyme A (CoA) substrate regulation, as elevating butyryl-CoA level resulted in 1,3-hexanediol product ratio increased from 11% to 77%. We also demonstrated that PKS-TR can produce biosynthetically challenging branched-chain diols, culminating in production of 166 mg/L branched-chain 2-methyl-1,3-diols via acyltransferase exchange.
DOI: 10.6084/m9.figshare.c.3638873_d7.v1
title: Additional file 4: of Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

description: Metabolites detected and quantified by LC/DFI-MS/MS-based profiling. Compound abundances are provided for each of 4 replicates (labeled A, B, C, D) for all 20 plant species. Means and standard deviations (SD) are provided for each metabolite. Species abbreviations are defined in TableÂ 1. A complete listing of full compound names and abbreviations is available online: http://www.biocrates.com/products/research-products/absoluteidq-p150-kit . (XLS 317 kb)
DOI: 10.6084/m9.figshare.c.3638873_d8.v1
title: Additional file 3: of Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

description: Metabolites detected and quantified by NMR-based profiling. Compound abundances (mg/g dry weight) are provided for each of 4 replicates (labeled A, B, C, D) for all 20 plant species. Meansâ  Âąâ  SD are provided for each metabolite. Species abbreviations are defined in TableÂ 1. (XLS 213 kb)
DOI: 10.6084/m9.figshare.c.3638873_d11.v1
title: Additional file 9: of Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

description: Exact mass list acquired using UPLC-FTMS analysis in positive ion mode. UPLC retention time (Rt) and total ion count is provided for each ionic mass (m/z) for all 4 replicates (labeled A, B, C, D) for each of 20 plant species. Species abbreviations are defined in TableÂ 1. (XLSX 644 kb)
DOI: 10.17863/cam.108563
title: Research data supporting "Co-transcriptional production of programmable RNA condensates and synthetic organelles"

description: Data repository for work contributing to the paper "Co-transcriptional production of programmable RNA condensates and synthetic organelles". The repository contains 24 ZIP archives and 1 README file describing the repository in detail. Epifluorescence timelapses, confocal micrographs and zoomed z-stacks data either reported in main text/SI or used for analysis are presented as pristine (no further processing) and displayed in TIFF format. Where single equatorial planes extracted from a z-stack were reported, entire pristine z-stacks are included. Depending on filesize, images might have been binned (specified in filename, e.g. "bin4x4"). For z-stacks data, images might have been binned (specified in filename, e.g. "bin2x2x2"). Gel images are included in a ZIP archive containing all (pristine and processed, i.e. inverted and/or rotation-corrected, gel images) reported in SI and used for analysis. Platereader fluorescence measurements were acquired using a BMG CLARIOstar Plus plate reader, data is presented in .csv format. See the main manuscript and SI (all open access) for further details on samples and data collection methods.
DOI: 10.6084/m9.figshare.c.3638873_d10.v1
title: Additional file 16: of Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

description: Principal Component Analysis (PCA) loadings data corresponding to metabolites quantified by NMR, LC/DFI-MS/MS, HPLC-UV, or UPLC-FTMS analyses. Loadings for principal components (PC) 1 through 5 are shown. (XLS 114 kb)
DOI: 10.6084/m9.figshare.c.3638873_d12.v1
title: Additional file 6: of Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

description: Metabolites detected and quantified by HPLC-UV-based profiling. Compound abundances (mg/g dry weight) are provided for each of 4 replicates (labeled A, B, C, D) for all 20 plant species. Means ± SD are provided for each metabolite. Species abbreviations are defined in Table 1. (XLS 218 kb)
DOI: 10.6084/m9.figshare.c.3638873_d14.v1
title: Additional file 10: of Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

description: Exact mass list acquired using UPLC-FTMS analysis in negative ion mode. UPLC retention time (Rt) and total ion count is provided for each ionic mass (m/z) for all 4 replicates (labeled A, B, C, D) for each of 20 plant species. Species abbreviations are defined in TableÂ 1. (XLSX 1216 kb)
DOI: 10.6084/m9.figshare.c.3638876_d1.v1
title: MOESM1 of Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) to viral and bacterial infections

description: Additional file 1. Â List of primer from antiviral and antibacterial gene selection. Table listing primers used in the high throughput RT-qPCR analysis with their respective nucleic sequence, Genbank reference and BLAST hits.
DOI: 10.6084/m9.figshare.c.3638876_d2.v1
title: MOESM2 of Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) to viral and bacterial infections

description: Additional file 2. Â List of regulated genes in juveniles and adults in response response to OsHV-1, V. aestuarianus and V . tasmaniensis LGP32. Statistical analysis of qPCR data was performed separately for juvenile and adult oysters. Two-way analysis of variance (ANOVA) was conducted to individually assess expression levels of the 102 target genes using the univariate general linear model (GLM) with post hoc Tukeyâ  s HSD test in IBM SPSS Statistics v 20.0.
DOI: 10.6084/m9.figshare.c.3638897_d1.v1
title: MOESM2 of Treatment-seeking rates in malaria endemic countries

description: Additional file 2: Title: National level treatment-seeking and indicator data for malaria-endemic countries. Description: Treatment-seeking data extracted from national surveys and national-level indicator data from the World Bank are provided here along with the predicted estimates derived from the models described in the main text and Additional file 1.
DOI: 10.17863/cam.44432
title: Research data supporting "Impact of UV- and carbodiimide-based crosslinking on the integrin-binding properties of collagen-based materials"

description: Data set used to generate the figures in the Acta Biomaterialia paper titled 'Impact of UV- and carbodiimide-based crosslinking on the integrin-binding properties of collagen-based materials'. Each figure and supplementary figure has a separate tab in the excel spread sheet containing all of the data used to generate that specific figure. Absorbance data were obtained on a Fluostar Optima plate reader. ATR FTIR data were obtained on a Bruker Tensor 27 FTIR. Phase contrast images were obtained on a LEICA DMI6000CS phase contrast microscope fitted with a LEICA DFC340FX camera. This work was undertaken within the following research projects: 1) EPSRC Fellowship EP/N019938/1 2) ERC Advanced Grant 320598 3D-E 3) British Heart Foundation Special Project SP/15/7/31561 4) Peoples Programme of the EU 7th Framework Programme [RAE no: PIIF-GA-2013-624904].
DOI: 10.17863/cam.78025
title: Research data supporting ''Realizing discontinuous quantum phase transitions in a strongly-correlated driven optical lattice''

description: Hierarchical Data Format version 5 (HDF5) file contains both experimental and simulation data underlying the figures in the paper. HDF5 file contains experimental data of the Mott insulator and the π-superfluid, phase diagrams, dynamics of phase transitions and corresponding theoretical simulations. Additional information is available in the 'README' file, and see the paper for more details. Contact details: uws20@cam.ac.uk.
DOI: 10.17863/cam.6486
title: Research data supporting "The interaction between CuO and Al2O3 and the reactivity of copper aluminates below 1000°C and their implication on the use of the Cu-Al-O system for oxygen storage and production"

description: The data set contain the original research data presented in the paper corresponding to the relevant figures and table shown in the article and the accompanying supplementary information.
DOI: 10.6084/m9.figshare.c.3638930_d2.v1
title: MOESM4 of Genomic prediction of survival time in a population of brown laying hens showing cannibalistic behavior

description: Additional file 4. Output which includes predicted response to selection and rate of inbreeding from selAction software for genomic selection.
DOI: 10.6084/m9.figshare.c.3638930_d1.v1
title: MOESM1 of Genomic prediction of survival time in a population of brown laying hens showing cannibalistic behavior

description: Additional file 1. Input used for selAction software to predict response to selection and rate of inbreeding for traditional selection.
DOI: 10.6084/m9.figshare.c.3638930_d3.v1
title: MOESM3 of Genomic prediction of survival time in a population of brown laying hens showing cannibalistic behavior

description: Additional file 3. Output which includes predicted response to selection and rate of inbreeding from selAction software for traditional selection.
DOI: 10.17863/cam.55394
title: Research data supporting "Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics"

description: The supporting data include microscopy images, quantitative analyses of images, and statistical analyses, for each figure presented in the linked paper. See the Readme.pdf file for a detailed description of the contents of each folder and for a list of file formats.
DOI: 10.6084/m9.figshare.c.3638930_d5.v1
title: MOESM2 of Genomic prediction of survival time in a population of brown laying hens showing cannibalistic behavior

description: Additional file 2. Input used for selAction software to predict response to selection and rate of inbreeding for genomic selection.
DOI: 10.6084/m9.figshare.c.3638942_d2.v1
title: Additional file 1: of Time-dependent postural control adaptations following a neuromuscular warm-up in female handball players: a randomized controlled trial

description: Master data. The file includes a table with the full dataset of this study. (XLSX 22Â kb)
DOI: 10.6084/m9.figshare.c.3638945_d1.v1
title: Additional file 1: of Anti-proliferative and anti-migration effects of Polish propolis combined with Hypericum perforatum L. on glioblastoma multiforme cell line U87MG

description: The row data of MTT, [3H]-thymidine incorporation and MMPs secretion tests. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.c.3638951_d1.v1
title: Additional file 2: Table S2. of Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis

description: Characteristics of 22 included studies. aDemographics of 57 RA patients and 16 other arthritides not stated, total population provided. bDetails not reported. cELISA (EA, VCA), immunofluorescence (EBNA-1). dImmunoblotting used for EBNA-2a, 2b and -1, immunofluorescence used for VCA and EA. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.c.3638963_d2.v1
title: Additional file 2: Table S1. of The potential of a multiplex high-throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study

description: Results of deterministic sensitivity analyses (XLSX 20 kb)
DOI: 10.17863/cam.77640
title: Research data supporting "Detecting mid-infrared light by molecular frequency upconversion with dual-wavelength hybrid nanoantennas"

description: This folder contains research data from every figure in the paper. Briefly, files contain the reflection of the nanoparticle-on-resonator (NPoR) in visible and mid-infrared regime. Further, we enclose experiment data of surface enhanced Raman spectroscopy (SERS) of the constructs under study, as described in the linked manuscript. Here, we perform power dependent frequency upconversion measurements while measuring SERS. We show upconversion with pump ON and OFF. Then we show detail upconversion measurements for 40 NPoRs where we focus in various Stokes and antiStokes peaks for clarity. Lastly, we examine the mid-infrared tuning dependence of the frequency upconversion.
DOI: 10.17863/cam.80292
title: Data from Axelsson et al 2021 "Flexible versus Fixed Spatial Self-Ordered Response Sequencing: Effects of inactivation and neurochemical modulation of ventrolateral prefrontal cortex" Journal of Neuroscience

description: Previously, studies using human neuroimaging and excitotoxic lesions in non-human primate have demonstrated an important role of ventrolateral prefrontal cortex (vlPFC) in higher order cognitive functions such as cognitive flexibility and the planning of behavioral sequences. In the present experiments, we tested effects on performance of temporary inactivation (using GABA receptor agonists) and dopamine D2 and 5-HT2A receptor blockade of vlPFC via local intracerebral infusions in the marmoset. We trained common marmosets to perform spatial self-ordered sequencing tasks in which one cohort of animals performed 2 and 3 response sequences on a continuously varying spatial array of response options on a touch-sensitive screen. Inactivation of vlPFC produced a marked disruption of accuracy of sequencing which also exhibited significant error perseveration. There were somewhat contrasting effects of D2 and 5HT2A receptor blockade, with the former producing error perseveration on incorrect trials, though not significantly impairing accuracy overall, and the latter significantly impairing accuracy but not error perseveration. A second cohort of marmosets were directly compared on performance of fixed versus variable spatial arrays. Inactivation of vlPFC again impaired self-ordered sequencing, but only with varying, and not fixed spatial arrays, the latter leading to the consistent use of fewer, preferred sequences. These findings add to evidence that vlPFC is implicated in goal-directed behavior that requires higher-order response heuristics that can be applied flexibly over different (variable), as compared to fixed stimulus exemplars. They also show that dopaminergic and serotonergic chemomodulation has distinctive effects on such performance. The behavioural data provided in this dataset support the publication "Flexible versus Fixed Spatial Self-Ordered Response Sequencing: Effects of Inactivation and Neurochemical Modulation of Ventrolateral Prefrontal Cortex".
DOI: 10.17863/cam.9031
title: Research Data in support of: Crystallization of Amphiphilic DNA C-Stars

description: Confocal microscopy z-stacks of aggregates of Alexa-488 labelled C-stars with n=3,4,6.
DOI: 10.17863/cam.34765
title: Research data supporting: "Quantitative modelling of the erosive removal of a thin soil deposit by impinging liquid jets"

description: This Microsoft Excel spreadsheet contains the data sets used for construction of Figures S1 to S10 of the manuscript. The file 'data - supplementary figures S1 to S10.xlsx' is divided in 10 sheets accordingly named. Figures S1 to S9 contain the results of video analysis using an automated script developed by the authors to identify the area of the cleaned region generated by a perpendicular coherent impinging water jet, with different nozzle diameters and jet velocities, from the experiments presented in: Kaye, P.L., Pickles, C.S.J., Field, J.E. and Julien, K.S. Investigation of erosion processes as cleaning mechanisms in the removal of thin deposited soils, Wear, 186-187 (1995) 413- 420. DOI: 10.1016/0043-1648 (95)07152-0 The original videos were provided by Dr Peter Kaye. These showed the growth of a cleaned region on a Perspex plate over time following impingement of a water jet. The videos were transferred into MATLAB and analysed using its Image Analysis Toolbox. Figure S10 describes the values of the jet’s traversal velocity as a function of length/width (ratio between the length and width of the trail generated by the moving jet) for the experiments conducted by Kaye et al. (1995) and the model described in the manuscript, for both the strong soil and weak soil regimes, and with different values of the radius when the cleaning front is first seen. These data were obtained by measuring the aspect ratio of the trails generated by the jet from the photographs presented in the Kaye et al. paper and the PhD disseration of Dr PL Kaye.
DOI: 10.5281/zenodo.14503002
title: Architecting Immortality: Building an Inverted Matrix to Maximize Artificial Intelligence for Real-World Simulation

description: Brain-computer Interface technologies (BCIs) possess the potential to unlock and render the informational interactions and generations of the human neocortex and sensorimotor systems of the body in real-time. Researchers predict that these advancements could be accurate enough to distinguish subtle differences of thought ranging through cognitive domains such as intention, planning, preparation, execution, affective domains of thought, cultural differences, and even understanding an individual’s embodied interactions within their physical environment—all serving as potential inputs for AI development. While current simulations are utilized for researching outcomes predicated on variable instantiations of data, I assess that if such a fine-grained interface is achieved, then our Primary World could, itself, be inverted into a simulation. If viable, the data derived from BCIs could also be backpropagated for architecting an increasingly believable real-world simulation(s) congruent with the Simulation Hypothesis. While the scale of these developments requires a multi-worldview think tank to navigate the potential outcomes of BCI advancements, in this article I will utilize J. R. R. Tolkien’s incite, predicated on a Christian worldview, on how imaginative literary Secondary Worlds influence the Primary World, and then apply Tolkien's wisdom to digital Secondary Worlds—Worlds that may draw the Primary World into themselves.
DOI: 10.3535/njb-ds7-41r
title: Euploea eunice (Godart)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.17026/dans-z8h-9j2g
title: Bureauonderzoek Woon-Werklocatie te Ittervoort (gem. Leudal)
title: BO en IVO-O woonwerklocatie Ittervoort

description: &lt;p&gt;BO en IVO-O verkennende fase ivm een bestemmingsplan (bouw woningen en bedrijven) Start BO 11-7, start IVO-O nog onbekend&lt;/p&gt;
description: &lt;p&gt;Ittervoort - Woon-werklocatie Ittervoort&lt;/p&gt;
description: &lt;p&gt;BO en IVO-O woonwerklocatie Ittervoort&lt;/p&gt;
description: Date: 2011-07-11 (veldwerk)
DOI: 10.3535/21k-3sq-9cq
title: Mimas tiliae Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/7rr-8rv-b6d
title: Deilephila elpenor Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g0m-3m5-qzn
title: Mycalesis perseus Fabricius, 1775

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/2xj-mvw-13h
title: Mimas tiliae Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/afb-6pj-9pl
title: Pieridae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/n50-v5v-1vs
title: Cyrestis lutea Zincken, 1831

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/123-zbw-xqk
title: Vindula erota pallida (Staudinger, 1885)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6sm-kne-2l8
title: Nymphalidae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.17026/dans-z8h-armv
title: Plangebied Goudtsjepoel te Oudega, gemeente Smallingerland

description: &lt;p&gt;onderzoeksrapport&lt;/p&gt;
description: Date: 07-12-2005 (aanvang onderzoek)
DOI: 10.3535/fkq-v02-lsw
title: Notodonta tritophus ([Denis & Schiffermüller], 1775)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/k01-gng-0mx
title: Hyles Hübner, 1819

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/elp-blq-mev
title: Mimas tiliae Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/sq3-a1w-px1
title: Taenaris macrops Felder, 1860

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.17026/dans-z8h-aw4j
title: 's-Hertogenbosch, bastion Anthonie
title: Archeologisch onderzoek

description: &lt;p&gt;Voor zover waargenomen heeft de oorspronkelijke bastionmuur uit 1618 een aanlegdiepte van ca. 1,20 NAP+ en is bewaard gebleven tot een hoogte van 5,22 NAP+ aan de stadszijde van het bastion. De dikte van de muur loopt van onder naar boven op van 2,30 naar 1,70 m. Aan de stadszijde is de muur voorzien van steunberen die in verband staan met de muur uit 1618. Ze zijn 1,24 m breed en 1,35 m diep. Tussen de steunberen zit een afstand van ca. 8,50 m.&lt;br&gt;Aan de veldzijde bestaat het muuroppervlak grotendeels uit een klampmuur, die begint bij een hoogte van ca. 2,20 NAP+ en bewaard is gebleven tot ca. 5,80 NAP+ en waarschijnlijk uit de eerste helft van de negentiende eeuw stamt. Het bovendeel van het huidige bastion en de stadsmuur die er aan de zuidelijke zijde aan grenst wordt gevormd door ca. 0,80 m zichtwerk met daarop een rollaag en dateert van na 1874. Wat betreft de relatie van de bastionmuur met de stadsmuur konden alleen jongere fases van de muren aan elkaar gerelateerd worden: de herstelling van het bastion is jonger dan de vernieuwde stadsmuur.&lt;br&gt;Bij de muur van het bastion is wel een deel van het voorland maar niets van de stadsgracht zelf gezien en hetzelfde geldt voor de in 1618 gedempte gracht die langs de stadsmuur liep. Boven de lagen van het voorland is een pakket lagen waargenomen dat na demping van de gracht om het bastion in 1908 is aangebracht, waarbij het deels gaat om lagen vuilstort.&lt;/p&gt;
DOI: 10.3535/y8c-tnk-6t2
title: Zeuxidia luxerii Hübner, 1826

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/00x-z5b-lhw
title: Tirumala hamata (MacLeay, 1826)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cq2-rbx-n5p
title: Agrius convolvuli Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.