cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17179/excli2022-5556/supplementary_data
title: Antineoplastic multi-drug chemotherapy to sensitize tumors triggers multi-drug resistance and inhibits efficiency of maintenance treatment in glioblastoma cells

description: Combinations of the well-known antineoplastic agents 5-fluorouracil (5-Fu), cisplatin, and paclitaxel are employed to increase radiotherapy/immunotherapy efficacy against persistent and resistant tumors. However, data remains needed on the hormetic, chronic, and long-term side effects of these aggressive combination chemotherapies. Here we investigated cellular and molecular responses associated with these combined agents, and their potential to induce multi-drug resistance against the temozolomide (TMZ) and etoposide (EP) used in glioblastoma maintenance treatment. We analyzed resistance and survival signals in U87 MG cells using molecular probes, fluorescent staining, qRT-PCR, and immunoblot. Repeated treatment with combined 5-Fu, cisplatin, and paclitaxel induced cross-resistance against TMZ and EP. Resistant cells exhibited elevated gene/protein expression of MRP1/ABCC1, ABCC2, BRCP/ABCG2, and GST. Moreover, they managed oxidative stress, cell cycle, apoptosis, and autophagy signaling to ensure survival. In these groups TMZ and etoposide efficiency dramatically reduced. Our result suggests that combined high-dose treatments of classical antineoplastic agents to sensitize tumors may trigger multi-drug resistance and inhibit maintenance treatment. When deciding on antineoplastic combination therapy for persistent/resistant glioblastoma, we recommend analyzing the long-term hormetic and chronic effects on cross-resistance and multi-drug resistance in primary cell cultures from patients.
description: EXCLI Journal; 22:Doc35; ISSN 1611-2156
DOI: 10.6084/m9.figshare.21655997.v1
title: Supplementary Material for: State-of-the-Art Opinion Article on Ventilator-Induced Diaphragm Dysfunction: Update on Diagnosis, Clinical Course, and Future Treatment Options

description: Evidence from both animal and human studies now supports the development of ventilator-induced diaphragm dysfunction (VIDD) starting as early as 24 h after initiation of mechanical ventilation in the intensive care unit (ICU). However, although the concept of VIDD is now widely accepted, there remain several unanswered questions regarding its pathophysiology, rate of development, and (potentially) recovery after mechanical ventilation.This state-of-the-art opinion article briefly explains VIDD and provides an update on its clinical and prognostic relevance. It then focusses on state-of-the-art diagnostic approaches to determine diaphragm function, strength, and control (neural and peripheral), highlights knowledge gaps relevant to VIDD, and discusses the use of diaphragm pacing for VIDD prevention. It is suggested that future research projects in mechanically ventilated patients would ideally use both cortical and cervical phrenic nerve stimulation studies over time (including also diaphragm electromyography) as the gold standard techniques. This approach has not yet been utilized in a longitudinally designed study in the ICU. Application of these gold standard techniques would allow better understanding of the true pathophysiology and rate of development of VIDD. Notably, these techniques would be superior to diaphragm ultrasound, which yields surrogate markers of diaphragm function only without any direct measure of diaphragm strength or control. It is also suggested that such translational research would further advance understanding of diaphragm pacing as a very promising treatment option for VIDD.
DOI: 10.5281/zenodo.7502958
title: Open Access

description: Open access
DOI: 10.6084/m9.figshare.21655997.v2
title: Supplementary Material for: State-of-the-Art Opinion Article on Ventilator-Induced Diaphragm Dysfunction: Update on Diagnosis, Clinical Course, and Future Treatment Options

description: Evidence from both animal and human studies now supports the development of ventilator-induced diaphragm dysfunction (VIDD) starting as early as 24 h after initiation of mechanical ventilation in the intensive care unit (ICU). However, although the concept of VIDD is now widely accepted, there remain several unanswered questions regarding its pathophysiology, rate of development, and (potentially) recovery after mechanical ventilation.This state-of-the-art opinion article briefly explains VIDD and provides an update on its clinical and prognostic relevance. It then focusses on state-of-the-art diagnostic approaches to determine diaphragm function, strength, and control (neural and peripheral), highlights knowledge gaps relevant to VIDD, and discusses the use of diaphragm pacing for VIDD prevention. It is suggested that future research projects in mechanically ventilated patients would ideally use both cortical and cervical phrenic nerve stimulation studies over time (including also diaphragm electromyography) as the gold standard techniques. This approach has not yet been utilized in a longitudinally designed study in the ICU. Application of these gold standard techniques would allow better understanding of the true pathophysiology and rate of development of VIDD. Notably, these techniques would be superior to diaphragm ultrasound, which yields surrogate markers of diaphragm function only without any direct measure of diaphragm strength or control. It is also suggested that such translational research would further advance understanding of diaphragm pacing as a very promising treatment option for VIDD.
DOI: 10.6084/m9.figshare.21813894
title: DAS.zip

description: Supplement Figures for manuscript of <em><strong>Salmonella</strong></em><strong> effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection</strong>
DOI: 10.26165/juelich-data/qljk8d
title: Data for: Topological Material-Based Three-Terminal Junctions

description: This Repository contains the code and data which is part of the publication and can be used to create the contained figures. It is structured into a notebook for the simulation part and a notebook for the experimental data analysis.
DOI: 10.5517/ccdc.csd.cc2dmnf4
title: CCDC 2223426: Experimental Crystal Structure Determination

description: Related Article: I. Andrusenko, C.L. Hall, E. Mugnaioli, J. Potticary, S.R. Hall, W. Schmidt, S. Gao, K. Zhao, N. Marom, M. Gemmi|2023|IUCrJ|10|131|doi:10.1107/S205225252201154X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dphxj
title: CCDC 2225208: Experimental Crystal Structure Determination

description: Related Article: I. Andrusenko, C.L. Hall, E. Mugnaioli, J. Potticary, S.R. Hall, W. Schmidt, S. Gao, K. Zhao, N. Marom, M. Gemmi|2023|IUCrJ|10|131|doi:10.1107/S205225252201154X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dphyk
title: CCDC 2225209: Experimental Crystal Structure Determination

description: Related Article: I. Andrusenko, C.L. Hall, E. Mugnaioli, J. Potticary, S.R. Hall, W. Schmidt, S. Gao, K. Zhao, N. Marom, M. Gemmi|2023|IUCrJ|10|131|doi:10.1107/S205225252201154X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.7503012
title: Aridity-dependent sequence of water potentials for wilting, stomatal closure, and embolism in woody plants

description: The dataset of the paper "Aridity-dependent sequence of water potentials for wilting, stomatal closure, and embolism in woody plants"
DOI: 10.5281/zenodo.7503011
title: Aridity-dependent sequence of water potentials for wilting, stomatal closure, and embolism in woody plants

description: The dataset of the paper "Aridity-dependent sequence of water potentials for wilting, stomatal closure, and embolism in woody plants"
DOI: 10.34740/kaggle/ds/2782916
title: Physical activity
DOI: 10.6084/m9.figshare.21805761.v1
title: CMIP6_ISIMIP_GCM

description: The climatic variables calculated with the outputs of CMIP6_ISIMIP five GCMs under SSP126, SSP245, SSP585. All the climate variables are calculated based on corn-specific indicators
DOI: 10.6084/m9.figshare.21805170
title: Supplementary Material for: Interleukin-11 Is Elevated in Patients with Atrial Fibrillation, Correlates with Serum Fibrosis Markers, and Represents a Therapeutic Target for Atrial Fibrosis

description: <b><i>Introduction:</i></b> Inflammatory cytokines are closely associated with developing cardiac fibrosis. This research aimed to explore the significant role of IL-11 in atrial fibrosis progression and potential therapeutic targets. <b><i>Methods:</i></b> 207 AF patients and 160 healthy subjects were included in the case-control study. Blood samples were analyzed for the level of IL-11 by enzyme-linked immunosorbent assay (ELISA). Angiotensin II (Ang II)-treated fibrosis mouse models were generated, and expression of IL-11 mRNA and protein was detected by RT-qPCR and Western blot. IL-11 antagonist was used to evaluating atrial fibrosis-related markers. <b><i>Results:</i></b> The persistent atrial fibrillation patients (<i>n</i> = 76) had significantly larger left atrial size, higher serum levels of hypertrophic protein BNP, proinflammatory cytokine high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) compared to paroxysmal atrial fibrillation patients (<i>n</i> = 131), and healthy subjects (all <i>p</i> &lt; 0.05). Pearson correlation analysis revealed significant positive correlation between serum IL-11 and cardiac fibrosis markers BNP (<i>r</i> = 0.394, <i>p</i> &lt; 0.001), CTX-I (<i>r</i> = 0.418, <i>p</i> &lt; 0.001), PICP (<i>r</i> = 0.306, <i>p</i> &lt; 0.001), PIIINP (<i>r</i> = 0.335, <i>p</i> &lt; 0.001), and TGF-β1 (<i>r</i> = 0.273, <i>p</i> &lt; 0.001). In the fibrosis mouse model, Ang II infusion significantly upregulated IL-11 mRNA and protein expression in the left atrium of mice (<i>p</i> &lt; 0.05), as well as staining intensity of Masson trichrome, the intensity of α-SMA, and it increased mRNA expression of collagen I and III in atrial tissue. IL-11 antagonist treatment significantly attenuated Masson trichrome, number of α-SMA-positive myofibroblasts in atrial tissue. Also, it significantly reduced the p-ERK1/2 in atrial tissue of mice infused with Ang II (<i>p</i> &lt; 0.05). <b><i>Conclusions:</i></b> IL-11 is upregulated in the serum of AF patients, and IL-11 inhibitor significantly inhibited Ang II-induced atrial fibrosis, a key pathological feature of AF. Therefore, IL-11 could be a potential therapeutic target for AF.
DOI: 10.24378/exe.4304
title: Cloud- and haze-free Met Office Unified Model simulations of the atmospheres of HAT-P-11b, HD 189733b, HD 209458b, and WASP-17b (dataset)

description: This dataset contains the Met Office Unified Model output from a set of cloud- and haze-free 1x solar metallicity simulations of the atmospheres of HAT-P-11b, HD 189733b, HD 209458b, and WASP-17b. The dataset includes 8 simulations in total: two simulations (one with the chemical equilibrium scheme and the other with the chemical kinetics scheme) per target. Each simulation was run till pseudo-steady state. The dataset presents: - The stellar and planetary parameters used as input into the model. - The last 200 days (20 time slices of every-10-days frequency output) for the following variables: eastward wind (u), northward wind (v), upward air velocity (w), air pressure, air temperature, and mole fractions of CH4, CO, CO2, H2O, HCN, and NH3 in air. - The synthetic transmission and emission spectra covering 2-30 micrometer range and phase curves at 3.6, 4.5, 5.8, 8.0 and 10.5 micrometer bandpasses obtained at pseudo-steady state.
description: The article associated with this dataset is available in ORE at: http://hdl.handle.net/10871/131802
DOI: 10.6084/m9.figshare.21805593.v1
title: Supplementary Material for: Nasal Provocation Challenges with <b><i>Aedes aegypti</i></b> Whole-Body Extract Induces Allergic Rhinitis

description: <b><i>Background:</i></b> Exposure to mosquitoes in the Tropics is perennial, and their somatic and saliva antigens have shown IgE binding capacity, although it is not clear whether this is due to cross-reactivity or primary sensitization. Inhalation of these allergens could trigger an allergic response. <b><i>Objective:</i></b> The aim of the study was to evaluate the clinical relevance of sensitization t<i>o Aedes aegypti</i> in a group of patients with allergic rhinitis. <b><i>Methods:</i></b> A cross-sectional study with allergic rhinitis subjects and healthy controls sensitized to mosquito extract was performed. Sensitization to mosquito and house dust mites was evaluated using skin prick test (SPT) and antibody determination by ELISA. Nasal provocation test (NPT) with whole-body extract was used to determine clinical relevance. <b><i>Results:</i></b> Allergic rhinitis patients were more sensitized to mosquito extract than controls with (+) SPT (66.6% vs. 7.6%). From these (+) SPT patients, 44.5% had (+) NPT, and just two (11%) presented mono-sensitization to mosquito. Antibody reactivity was similar between patients and controls; however, (+) NPT patients showed a tendency to had higher levels of IgE and IgG<sub>4.</sub> <b><i>Discussion:</i></b> Mosquitoes are perennial in most tropical areas, and their body allergens could be associated with respiratory allergies.
DOI: 10.21227/6ya7-gn20
title: Modified Temporal 115-bus data

description: The data is for safe deep reinforcement learning in Microgrid. Temporal data with wind, photovoltaic, temperature, and inflexible power demand are designed for 52 days (4 seasons).
DOI: 10.21227/121v-0g65
title: Modified Temporal 115-bus data

description: The data is for safe deep reinforcement learning in Microgrid. Temporal data with wind, photovoltaic, temperature, and inflexible power demand are designed for 52 days (4 seasons).
DOI: 10.23728/b2share.b0026177b7c74fe5ba4bcaafb393b4a0
title: Ansys model files and related data

description: The uploaded files include the ansys model and relevant data.
DOI: 10.20372/eiar-rdm/l392i7/j4phqe
title: 192009-Article Text-486942-1-10-20200102 (4).pdf

description: :unav
DOI: 10.20372/eiar-rdm/l392i7
title: Analysis of Costs of Production and Profitability for Irrigated Cotton under Smallholder Production Systems; the Case of Middle Awash Valley

description: The continuous increase of input costs and volatility of output prices have made the profitability and sustainability of smallholder cotton production in question. This study was carried out to examine the profitability of irrigated cotton production at Amibara district in the Middle Awash Valley under smallholder producers. 30 producers were purposively selected from the villages considered based on the predominance of irrigated cotton production. Primary data were collected for this study using well-structured questionnaires. Data were analyzed using descriptive statistics and budgetary technique analysis. Likewise, break-even and sensitivity analyses were introduced to determine the break-even price and yield and to account to any changes and risks envisaged. The break-up of production cost structure showed that operational (both manual and machinery) expenses were the prominent components of all variable costs. The principal findings of the enterprise budget analysis was that smallholder irrigated cotton production was a profitable enterprise with a gross margin of 10,294.23 Birr per hectare and a total expenditure of 20,572.17 Birr per hectare. Moreover, the benefit cost ratio of 1.49 was obtained. The break-even price and break-even yield at which the producers are at no loss no profit were 8.35 Birr per kg and 1641.83 kg per hectare. Returns from irrigated cotton were highly sensitive to fluctuations of price and yield than total variable cost. Thus, efforts should be made to improve productivity through provision of appropriate agricultural inputs at the lowest possible cost and reduce price volatility by promoting primary cooperatives at district level working on input output marketing.
DOI: 10.20372/eiar-rdm/fy0e4o/5k0hnr
title: 142884-Article Text-379719-1-10-20160826.pdf

description: :unav
DOI: 10.20372/eiar-rdm/fy0e4o
title: The Effects of Drought Stress on Assimilate Availability and Metabolism in the Source and Sink Organs of Common Bean (Phaseolus vulgaris L) Genotypes

description: Changes in carbohydrate status and metabolism in the source and sink organs determine rate of growth and yield of plants subjected to drought stress. The objective of this study was to assess the effect of post-flowering drought stress on assimilate synthesis at source level and availability of the assimilates for metabolism in the reproductive sink organs of common bean (Phaseolus vulgaris L.) genotypes differing in degree of drought resistance. A drought-resistant inbred line (SEA 15) and a drought-susceptible cultivar (BrSp) were grown under non-stress and drought stress commenced at early pod-filling stage. Plants were raised in a vegetation hall during the summer of 2005. Drought stress reduced the seed yields of BrSp and SEA 15 by 53 and 30%, respectively. Harvest index of the susceptible genotype decreased by ca. 29%, whereas no effect of drought was found for the partitioning index in the resistant genotype implying marked differences in sink strength at whole plant level between the genotypes. Drought stress did not affect the concentration of sucrose in leaves and seeds of SEA 15 during most part of the stress period. On the contrary, the stress caused 18 to 30 and 29 to 47% reductions in leaf and seed sucrose concentrations of BrSp, respectively. Relative to control treatments, drought stress decreased seed starch accumulation of BrSp throughout the stress period (by 16 to 18%) whereas the decrease (by 20%) was found only at 20 d stress for SEA 15. The findings revealed that the underlying differences in sink establishment and yield of the bean genotypes differing in degree of drought resistance reside primarily in the capacity of the source to supply assimilates (i.e. source-strength) under drought conditions.
DOI: 10.5281/zenodo.7341147
title: Replication files for "The role of actors' issue and sector specialization for policy integration in the parliamentary arena: An analysis of Swiss biodiversity policy using text as data"

description: The ZIP file contains all data and code to replicate the analyses reported in the following paper. Reber, U., Ingold, K., & Fischer, M. (2023). The role of actors' issue and sector specialization for policy integration in the parliamentary arena: An analysis of Swiss biodiversity policy using text as data. <em>Policy Sciences</em>. https://doi.org/10.1007/s11077-022-09490-2 If you use any of the material included in this repository, please refer to the paper.
DOI: 10.5281/zenodo.7341146
title: Replication files for "The role of actors' issue and sector specialization for policy integration in the parliamentary arena: An analysis of Swiss biodiversity policy using text as data"

description: The ZIP file contains all data and code to replicate the analyses reported in the following paper. Reber, U., Ingold, K., & Fischer, M. (2023). The role of actors' issue and sector specialization for policy integration in the parliamentary arena: An analysis of Swiss biodiversity policy using text as data. <em>Policy Sciences</em>. https://doi.org/10.1007/s11077-022-09490-2 If you use any of the material included in this repository, please refer to the paper.
DOI: 10.15159/phytop.92
title: Small lakes 1999

description: Methods of phytoplankton processing. Samples were preserved with Lugol’s (acidified iodine) solution and processed using the Utermöhl (1958) method. Phytoplankton biomass was calculated from counts of cells or colonies using a Nikon Eclipse Ti-S inverted microscope at x200 and x400 magnification. Preserved sample (3 ml) was settled overnight. Identification and measurements took place in the course of counting. Counting units are independent (single) algal cells, colonies or filaments/trichomes. Biovolumes of algal cells, colonies and/or filaments were calculated using assigned geometric shapes dimensions, and converted to biomass assuming the specific density of 1 g cm-3 in accordance with Edler (1979). References of methods accepted Approved by CEN on 14 July 2006 “Water quality - Guidance standard on the enumeration of phytoplankton using inverted microscopy (Utermöhl technique)” (CEN 15204, 2006) European Standard EN 15204:2006 Edler, L. (ed.) 1979. Recommendations on methods for marine biological studies in the Baltic Sea. Phytoplankton and chlorophyll. – BMB WG 9. Utermöhl, H., (1958). Zur Vervollkommnung der quantitativen Phytoplankton-Methodik. Mitteilungen der Internationale Vereinigung für Theoretische und Angewandte Limnologie 9: 1-38. Biovolume calculation for pelagic and benthic microalgae | Request PDF. Available from: https://www.researchgate.net/publication/220031275_Biovolume_calculation_for_pelagic_and_benthic_microalgae [accessed Oct 29 2018]. The most commonly used traditional biomass estimate for microalgae is cell biovolume, which is calculated from microscopically measured linear dimensions (Steinman et al. 1991, Snoeijs 1994, Sommer 1994, 1995, Hillebrand and Sommer 1997). Huber-Pestalozzi, G., Komarek, J., Fott, B. 1983. Das Phytoplankton des Süsswassers. 7(1). Chlorophyceae. Chlorococcales. Stuttgart. 1044. S. Komarek, J., Anagnostidis, K. 1999. Süsswasserflora von Mitteleuropa. 19/1. Cyanoprocaryota. 1. Chroococcales. Elsevier Spectrum Academischer Verlag. Heidelberg. Berlin. 548 S. Komarek, J., Anagnostidis, K. 2005. Süsswasserflora von Mitteleuropa. 19/2. Cyanoprocaryota. 2. Oscillatoriales. Elsevier Spectrum Academischer Verlag. 759 S. Komárek, J., 2013. Cyanoprokaryota 3. Teil: Heterocystous Genera. Süsswasserflora von Mitteleuropa. B. 19/3. Springer Spektrum. 1130 S. Krammer, K., Lange-Bertalot, H. 1997-1991. Süsswasserflora von Mitteleuropa. Bacillariophyceae. B. 2, 1-4. Spectrum Academischer Verlag.Heidelberg. Berlin. Popovský, J., Pfiester, L.A. 2008. Dinophyceae (Dinoflagellida). Süsswasserflora von Mitteleuropa. B. 6. Springer Spektrum. 272 S. Косинская Е.К. 1960. Флора споровых растений СССР. Том 5. Конъюгаты и Сцеплянки. (2). Изд. АН СССР. Москва-Ленинград. 706 стр. In Russian.
DOI: 10.6084/m9.figshare.21805758
title: Regional Development Trap - Economic Complexity: NUTS-3 Turkey

description: Following Diemer et al. (2022) we have calculated the regional development trap, DT1 and DT2, for provinces of Turkey. We also calculated two economic complexity metrics, ECI and EFI. For ECI, we used Hidalgo and Hausmann's (2009) and Hausmann et al.'s (2014) methodology. For EFI, we followed Tacchella et al. (2012), Servedio et al. (2018), and Operti et al. (2018). <br> Description of variables in the dataset <br> countrycode: NUTS-3 code country: Name of provinces popdens: Population densit (person / sq. kilometers) DT1: Regional Development Trap Measure 1 DT2: Regional Development Trap Measure 2 fit: Economic Fitness Index (EFI) eci: Economic Complexity Index (ECI) pop: Total population pop1564: Working age population elksanpc: Electric consumption per capita egitim1: High school, faculty, master's, and PhD graduates to the working age population. openness: trade opennes <br> <br>