cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7314365.v1
title: Allen et al - Proceedings B Supplementary Data - Raw Data from Cultural revolutions reduce complexity in the songs of humpback whales

description: Much evidence for non-human culture comes from vocally learned displays, such as the vocal dialects and song displays of birds and cetaceans. While many oscine birds use song complexity to assess male fitness, the role of complexity in humpback whale (<i>Megaptera novaeangliae</i>) song is uncertain due to population-wide conformity to one song pattern. Although songs change gradually each year, the eastern Australian population also completely replaces their song every few years in cultural ‘revolutions’. Revolutions involve learning large amounts of novel material introduced from the Western Australian population. We examined two measures of song structure, complexity and entropy, in the eastern Australian population over 13 consecutive years. These measures aimed to identify the role of complexity and information content in the vocal learning processes of humpback whales. Complexity was quantified at two hierarchical levels: the entire sequence of individual sound ‘units’ and the stereotyped arrangements of units which comprise a ‘theme’. Complexity increased as songs evolved over time but decreased when revolutions occurred. No correlation between complexity and entropy estimates suggests that changes to complexity may represent embellishment to the song which could allow males to stand out amidst population-wide conformity. The consistent reduction in complexity during song revolutions suggests a potential limit to the social learning capacity of novel material in humpback whales.
DOI: 10.7284/126131
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise RR1614 using a Hawaii UHDAS instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126139
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise RR1614 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126143
title: Expendable Probe data collected during research cruise RR1614 using a Turo Quoll instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126132
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1614 using a Furuno GP-150 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126134
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1614 using a Ashtech ADU2 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126141
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1614 using a Trimble SPS351 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314323
title: Getting the best of Linked Data and Property Graphs: rdf2neo and the KnetMiner Use Case

description: Paper submitted to SWAT4LS 2018. We introduce rdf2neo, a tool to populate Neo4j databases starting from RDF data sets, based on a configurable mapping between the two. By employing agrigenomics-related real use cases, we show how such mapping can allow for a hybrid approach to the management of networked knowledge, based on taking advantage of the best of both RDF and property graphs.
DOI: 10.7284/126137
title: INS (Inertial Navigation System) data collected during research cruise RR1614 using a iXSea Phins instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126142
title: INS (Inertial Navigation System) data collected during research cruise RR1614 using a Kongsberg Seapath 320+ instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126130
title: Meteorological Station data collected during research cruise RR1614 using a SIO MET-System instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.12885755
title: Additional file 1 of First cases of contagious ovine digital dermatitis in Germany

description: Additional file 1: Clinical findings at the claws with footrot scoring according to Egerton and Roberts (1971) and additional findings. *TWDS = Total weighted digital score according to Whittington und Nicholls [41]. **CODD lesion grade according to Angell et al. [5].
DOI: 10.7284/126136
title: Winch data collected during research cruise RR1614 using a Markey DUTW-9-11 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314269
title: Example processed data

description: Example dataset processed by the pipeline.
DOI: 10.6084/m9.figshare.7314275
title: Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir <i>in vitro</i>

description: Paritaprevir (PTV) is a non-structural protein 3/4A protease inhibitor developed for the treatment of hepatitis C disease as a fixed dose combination of ombitasvir (OBV) and ritonavir (RTV) with or without dasabuvir.The aim of this study was to evaluate the effects of cytochrome P450 (CYP) 3A5 on <i>in vitro</i> PTV metabolism using human recombinant CYP3A4, CYP3A5 (rCYP3A4, rCYP3A5) and human liver microsomes (HLMs) genotyped as either <i>CYP3A5*1/*1</i>, <i>CYP3A5*1/*3</i> or <i>CYP3A5*3/*3</i>.The intrinsic clearance (CL<sub>int</sub>, <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) for the production of a metabolite from PTV in rCYP3A4 was 1.5 times higher than that in rCYP3A5. The PTV metabolism in <i>CYP3A5*1/*1</i> and <i>CYP3A5*1/*3</i> HLMs expressing CYP3A5 was comparable to that in <i>CYP3A5*3/*3</i> HLMs, which lack CYP3A5.CYP3A4 expression level was significantly correlated with PTV disappearance rate and metabolite formation. In contrast, there was no such correlation found for CYP3A5 expression level.This study represents that the major CYP isoform involved in PTV metabolism is CYP3A4, with CYP3A5 having a minor role in PTV metabolism. The findings of the present study may provide foundational information on PTV metabolism, and may further support dosing practices in HCV-infected patients prescribed PTV-based therapy. Paritaprevir (PTV) is a non-structural protein 3/4A protease inhibitor developed for the treatment of hepatitis C disease as a fixed dose combination of ombitasvir (OBV) and ritonavir (RTV) with or without dasabuvir. The aim of this study was to evaluate the effects of cytochrome P450 (CYP) 3A5 on <i>in vitro</i> PTV metabolism using human recombinant CYP3A4, CYP3A5 (rCYP3A4, rCYP3A5) and human liver microsomes (HLMs) genotyped as either <i>CYP3A5*1/*1</i>, <i>CYP3A5*1/*3</i> or <i>CYP3A5*3/*3</i>. The intrinsic clearance (CL<sub>int</sub>, <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) for the production of a metabolite from PTV in rCYP3A4 was 1.5 times higher than that in rCYP3A5. The PTV metabolism in <i>CYP3A5*1/*1</i> and <i>CYP3A5*1/*3</i> HLMs expressing CYP3A5 was comparable to that in <i>CYP3A5*3/*3</i> HLMs, which lack CYP3A5. CYP3A4 expression level was significantly correlated with PTV disappearance rate and metabolite formation. In contrast, there was no such correlation found for CYP3A5 expression level. This study represents that the major CYP isoform involved in PTV metabolism is CYP3A4, with CYP3A5 having a minor role in PTV metabolism. The findings of the present study may provide foundational information on PTV metabolism, and may further support dosing practices in HCV-infected patients prescribed PTV-based therapy.
DOI: 10.7284/126140
title: Winch data collected during research cruise RR1614 using a Markey DUSH-5 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.12885755.v1
title: Additional file 1 of First cases of contagious ovine digital dermatitis in Germany

description: Additional file 1: Clinical findings at the claws with footrot scoring according to Egerton and Roberts (1971) and additional findings. *TWDS = Total weighted digital score according to Whittington und Nicholls [41]. **CODD lesion grade according to Angell et al. [5].
DOI: 10.6084/m9.figshare.7314269.v2
title: Example processed data

description: Example dataset processed by the pipeline.
DOI: 10.7284/126554
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise RR1702 using a Hawaii UHDAS instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314275.v2
title: Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir <i>in vitro</i>

description: Paritaprevir (PTV) is a non-structural protein 3/4A protease inhibitor developed for the treatment of hepatitis C disease as a fixed dose combination of ombitasvir (OBV) and ritonavir (RTV) with or without dasabuvir.The aim of this study was to evaluate the effects of cytochrome P450 (CYP) 3A5 on <i>in vitro</i> PTV metabolism using human recombinant CYP3A4, CYP3A5 (rCYP3A4, rCYP3A5) and human liver microsomes (HLMs) genotyped as either <i>CYP3A5*1/*1</i>, <i>CYP3A5*1/*3</i> or <i>CYP3A5*3/*3</i>.The intrinsic clearance (CL<sub>int</sub>, <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) for the production of a metabolite from PTV in rCYP3A4 was 1.5 times higher than that in rCYP3A5. The PTV metabolism in <i>CYP3A5*1/*1</i> and <i>CYP3A5*1/*3</i> HLMs expressing CYP3A5 was comparable to that in <i>CYP3A5*3/*3</i> HLMs, which lack CYP3A5.CYP3A4 expression level was significantly correlated with PTV disappearance rate and metabolite formation. In contrast, there was no such correlation found for CYP3A5 expression level.This study represents that the major CYP isoform involved in PTV metabolism is CYP3A4, with CYP3A5 having a minor role in PTV metabolism. The findings of the present study may provide foundational information on PTV metabolism, and may further support dosing practices in HCV-infected patients prescribed PTV-based therapy. Paritaprevir (PTV) is a non-structural protein 3/4A protease inhibitor developed for the treatment of hepatitis C disease as a fixed dose combination of ombitasvir (OBV) and ritonavir (RTV) with or without dasabuvir. The aim of this study was to evaluate the effects of cytochrome P450 (CYP) 3A5 on <i>in vitro</i> PTV metabolism using human recombinant CYP3A4, CYP3A5 (rCYP3A4, rCYP3A5) and human liver microsomes (HLMs) genotyped as either <i>CYP3A5*1/*1</i>, <i>CYP3A5*1/*3</i> or <i>CYP3A5*3/*3</i>. The intrinsic clearance (CL<sub>int</sub>, <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) for the production of a metabolite from PTV in rCYP3A4 was 1.5 times higher than that in rCYP3A5. The PTV metabolism in <i>CYP3A5*1/*1</i> and <i>CYP3A5*1/*3</i> HLMs expressing CYP3A5 was comparable to that in <i>CYP3A5*3/*3</i> HLMs, which lack CYP3A5. CYP3A4 expression level was significantly correlated with PTV disappearance rate and metabolite formation. In contrast, there was no such correlation found for CYP3A5 expression level. This study represents that the major CYP isoform involved in PTV metabolism is CYP3A4, with CYP3A5 having a minor role in PTV metabolism. The findings of the present study may provide foundational information on PTV metabolism, and may further support dosing practices in HCV-infected patients prescribed PTV-based therapy.
DOI: 10.6084/m9.figshare.7314269.v1
title: Example processed data

description: Example processed dataset from the pipeline
DOI: 10.6084/m9.figshare.7314275.v1
title: Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir <i>in vitro</i>

description: Paritaprevir (PTV) is a non-structural protein 3/4A protease inhibitor developed for the treatment of hepatitis C disease as a fixed dose combination of ombitasvir (OBV) and ritonavir (RTV) with or without dasabuvir.The aim of this study was to evaluate the effects of cytochrome P450 (CYP) 3A5 on <i>in vitro</i> PTV metabolism using human recombinant CYP3A4, CYP3A5 (rCYP3A4, rCYP3A5) and human liver microsomes (HLMs) genotyped as either <i>CYP3A5*1/*1</i>, <i>CYP3A5*1/*3</i> or <i>CYP3A5*3/*3</i>.The intrinsic clearance (CL<sub>int</sub>, <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) for the production of a metabolite from PTV in rCYP3A4 was 1.5 times higher than that in rCYP3A5. The PTV metabolism in <i>CYP3A5*1/*1</i> and <i>CYP3A5*1/*3</i> HLMs expressing CYP3A5 was comparable to that in <i>CYP3A5*3/*3</i> HLMs, which lack CYP3A5.CYP3A4 expression level was significantly correlated with PTV disappearance rate and metabolite formation. In contrast, there was no such correlation found for CYP3A5 expression level.This study represents that the major CYP isoform involved in PTV metabolism is CYP3A4, with CYP3A5 having a minor role in PTV metabolism. The findings of the present study may provide foundational information on PTV metabolism, and may further support dosing practices in HCV-infected patients prescribed PTV-based therapy. Paritaprevir (PTV) is a non-structural protein 3/4A protease inhibitor developed for the treatment of hepatitis C disease as a fixed dose combination of ombitasvir (OBV) and ritonavir (RTV) with or without dasabuvir. The aim of this study was to evaluate the effects of cytochrome P450 (CYP) 3A5 on <i>in vitro</i> PTV metabolism using human recombinant CYP3A4, CYP3A5 (rCYP3A4, rCYP3A5) and human liver microsomes (HLMs) genotyped as either <i>CYP3A5*1/*1</i>, <i>CYP3A5*1/*3</i> or <i>CYP3A5*3/*3</i>. The intrinsic clearance (CL<sub>int</sub>, <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) for the production of a metabolite from PTV in rCYP3A4 was 1.5 times higher than that in rCYP3A5. The PTV metabolism in <i>CYP3A5*1/*1</i> and <i>CYP3A5*1/*3</i> HLMs expressing CYP3A5 was comparable to that in <i>CYP3A5*3/*3</i> HLMs, which lack CYP3A5. CYP3A4 expression level was significantly correlated with PTV disappearance rate and metabolite formation. In contrast, there was no such correlation found for CYP3A5 expression level. This study represents that the major CYP isoform involved in PTV metabolism is CYP3A4, with CYP3A5 having a minor role in PTV metabolism. The findings of the present study may provide foundational information on PTV metabolism, and may further support dosing practices in HCV-infected patients prescribed PTV-based therapy.
DOI: 10.7284/126566
title: Expendable Probe data collected during research cruise RR1702 using a Turo Quoll instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314260
title: Example dataset

description: The example dataset included in the installation package of the pipeline. The Example dataset consists of four files: Dark.tiff and Grid.tiff used for gain calibration, Beads.tiff used for camera alignment, and Experiment.tiff. <br><br>In the example, the binding experiment measures the kinetics of TtAgo:guide complex binding a target DNA containing two binding sites. The target was immobilized on the slide via a biotin-streptavidin interaction. Continuous acquisition of frames was started when the TtAgo:guide solution was flowed-in. In this experiment, 1,500 frames were collected at 5 frames/s.
DOI: 10.6084/m9.figshare.7314254
title: Supplementary Material for: Neonatal Glycaemia and Neurodevelopmental Outcomes: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Hypoglycaemia is the most common metabolic problem in neonates but there is no universally accepted threshold for safe blood glucose concentrations due to uncertainty regarding effects on neurodevelopment. <b><i>Objective:</i></b> To systematically assess the association between neonatal hypoglycaemia on neurodevelopment outcomes in childhood and adolescence. <b><i>Methods:</i></b> We searched MEDLINE, EMBASE, CINAHL, and PsycINFO from inception until February 2018. We included studies that reported one or more prespecified outcomes and compared children exposed to neonatal hypoglycaemia with children not exposed. Studies of neonates with congenital malformations, inherited metabolic disorders and congenital hyperinsulinism were excluded. Two authors independently extracted data using a customized form. We used ROBINS-I to assess risk of bias, GRADE for quality of evidence, and REVMAN for meta-analysis (inverse variance, fixed effects). <b><i>Results:</i></b> 1,665 studies were screened, 61 reviewed in full, and 11 included (12 publications). In early childhood, exposure to neonatal hypoglycaemia was not associated with neurodevelopmental impairment (<i>n</i> = 1,657 infants; OR = 1.16, 95% CI = 0.86–1.57) but was associated with visual-motor impairment (<i>n</i> = 508; OR = 3.46, 95% CI = 1.13–10.57) and executive dysfunction (<i>n</i> = 463; OR = 2.50, 95% CI = 1.20–5.22). In mid-childhood, neonatal hypoglycaemia was associated with neurodevelopmental impairment (<i>n</i> = 54; OR = 3.62, 95% CI = 1.05–12.42) and low literacy (<i>n</i> = 1,395; OR = 2.04, 95% CI = 1.20–3.47) and numeracy (<i>n</i> = 1,395; OR = 2.04, 95% CI = 1.21–3.44). No data were available for adolescents. <b><i>Conclusions:</i></b> Neonatal hypoglycaemia may have important long-lasting adverse effects on neurodevelopment that may become apparent at later ages. Carefully designed randomized trials are required to determine the optimal management of neonates at risk of hypoglycaemia with long-term follow-up at least to school age.
DOI: 10.7284/126555
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1702 using a Furuno GP-150 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314260.v2
title: Example dataset

description: The example dataset included in the installation package of the pipeline. The Example dataset consists of four files: Dark.tiff and Grid.tiff used for gain calibration, Beads.tiff used for camera alignment, and Experiment.tiff. <br><br>In the example, the binding experiment measures the kinetics of TtAgo:guide complex binding a target DNA containing two binding sites. The target was immobilized on the slide via a biotin-streptavidin interaction. Continuous acquisition of frames was started when the TtAgo:guide solution was flowed-in. In this experiment, 1,500 frames were collected at 5 frames/s.
DOI: 10.6084/m9.figshare.7314254.v1
title: Supplementary Material for: Neonatal Glycaemia and Neurodevelopmental Outcomes: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> Hypoglycaemia is the most common metabolic problem in neonates but there is no universally accepted threshold for safe blood glucose concentrations due to uncertainty regarding effects on neurodevelopment. <b><i>Objective:</i></b> To systematically assess the association between neonatal hypoglycaemia on neurodevelopment outcomes in childhood and adolescence. <b><i>Methods:</i></b> We searched MEDLINE, EMBASE, CINAHL, and PsycINFO from inception until February 2018. We included studies that reported one or more prespecified outcomes and compared children exposed to neonatal hypoglycaemia with children not exposed. Studies of neonates with congenital malformations, inherited metabolic disorders and congenital hyperinsulinism were excluded. Two authors independently extracted data using a customized form. We used ROBINS-I to assess risk of bias, GRADE for quality of evidence, and REVMAN for meta-analysis (inverse variance, fixed effects). <b><i>Results:</i></b> 1,665 studies were screened, 61 reviewed in full, and 11 included (12 publications). In early childhood, exposure to neonatal hypoglycaemia was not associated with neurodevelopmental impairment (<i>n</i> = 1,657 infants; OR = 1.16, 95% CI = 0.86–1.57) but was associated with visual-motor impairment (<i>n</i> = 508; OR = 3.46, 95% CI = 1.13–10.57) and executive dysfunction (<i>n</i> = 463; OR = 2.50, 95% CI = 1.20–5.22). In mid-childhood, neonatal hypoglycaemia was associated with neurodevelopmental impairment (<i>n</i> = 54; OR = 3.62, 95% CI = 1.05–12.42) and low literacy (<i>n</i> = 1,395; OR = 2.04, 95% CI = 1.20–3.47) and numeracy (<i>n</i> = 1,395; OR = 2.04, 95% CI = 1.21–3.44). No data were available for adolescents. <b><i>Conclusions:</i></b> Neonatal hypoglycaemia may have important long-lasting adverse effects on neurodevelopment that may become apparent at later ages. Carefully designed randomized trials are required to determine the optimal management of neonates at risk of hypoglycaemia with long-term follow-up at least to school age.
DOI: 10.7284/126557
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1702 using a Ashtech ADU2 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314260.v1
title: Example dataset

description: Example dataset to demonstrate the pipeline
DOI: 10.7284/126564
title: GNSS (Global Navigation Satellite System) data collected during research cruise RR1702 using a Trimble SPS351 instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/126561
title: HDSS (Hydrographic Doppler Sonar System) data collected during research cruise RR1702 using a SIO HDSS instrument system onboard the platform RV Roger Revelle

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7314239
title: Effect of cleaning gas stream on products in selective laser melting

description: The cleaning gas stream in a selective laser melting process is a crucial factor that functions to remove condensate and prevent oxidation during fusing. This study investigated the ejected powder during processing and the effect of cleaning gas flow on product quality in term of porosity. Our results showed that the flow rate of cleaning gas significantly affected the homogeneity of properties of manufactured products. Following the cleaning gas direction, the properties of manufactured parts were changed. The product characteristics when positioned closer the inlet gas were favorable, while reduced product quality was observed at a greater distance from the inlet gas. The results can be applied to the selective laser melting process to predict and diagnose the quality of printed parts.