cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23282762
title: Supplementary Material for: Indomethacin Prophylaxis Is Associated with Reduced Risk of Intraventricular Hemorrhage in Extremely Preterm Infants Born in the Context of Amniotic Infection Syndrome

description: <b><i>Background:</i></b> Amniotic infection syndrome (AIS) with perinatal inflammation may increase the susceptibility to intraventricular hemorrhage (IVH) in preterm infants. Given its anti-inflammatory and ductus arteriosus constricting capacities, we hypothesized that prophylactic administration of indomethacin reduces the incidence, severity, and consequences of IVH in the context of perinatal inflammation. <b><i>Methods:</i></b> We evaluated data of infants born between 2009 and 2020 of 22 + 0–25+6 weeks of gestation from 68 German Neonatal Network centers. The effect of indomethacin prophylaxis on outcomes was analyzed in univariate analyses and multivariate regression models including a subgroup of infants with available data on 5-year follow-up. <b><i>Results:</i></b> 4760 infants were included with a median gestational age of 24.6 SSW [interquartile range (IQR) 24.1w–25.2w] and a birth weight of 640 g [IQR 550–750 g]. 1767/4760 (37.1%) preterm infants were born in the context of AIS and 527/4760 (11.1%) received indomethacin prophylaxis. AIS infants receiving prophylactic indomethacin had lower rates of IVH (32.7% vs. 36.9%, <i>p</i> = 0.04), IVH III/IV (9.7% vs. 16.0%, <i>p</i> = 0.02) and the combined outcome of severe IVH or death (15.9% vs. 23.2%, <i>p</i> = 0.01) as compared to infants without prophylaxis. Multivariate logistic regression analyses confirmed our observations. In a subgroup analysis of 730 preterm infants at 5 years of age, we did not find any correlation between prophylactic indomethacin and intelligence quotient &lt;70 or cerebral palsy. <b><i>Conclusions:</i></b> Our observational data demonstrate that prophylactic indomethacin is associated with a reduced risk of IVH in the highly vulnerable subgroup of preterm infants &lt;26 weeks of gestation born from AIS.
DOI: 10.6084/m9.figshare.23545290
title: Supplementary Material for: Discontinuation of Renin-Angiotensin System Inhibitors and Clinical Outcomes in Chronic Kidney Disease: A Systemic Review and Meta-Analysis

description: <b><i>Background:</i></b> Discontinuation of renin-angiotensin system (RAS) inhibitors is common in patients with chronic kidney disease (CKD), and the potential danger has been reported in several studies. However, a comprehensive analysis has not been conducted. <b><i>Objectives:</i></b> This study sought to evaluate the effects of discontinuation of RAS inhibitors in CKD. <b><i>Method:</i></b> Relevant studies up to November 30, 2022, were identified in the PubMed, Embase, Web of Science, and Cochrane Library databases. Efficacy outcomes included the composite of all-cause mortality, cardiovascular events, and end-stage kidney disease (ESKD). Results were combined using a random-effects or fixed-effects model, and sensitivity analysis used the leave-one-out method. <b><i>Results:</i></b> Six observational studies and one randomized clinical trial including 244,979 patients met the inclusion criteria. Pooled data demonstrated that discontinuation of RAS inhibitors was associated with an increased risk of all-cause mortality (HR 1.42, 95% CI 1.23–1.63), cardiovascular event risk (HR 1.25, 95% CI 1.17–1.22), and ESKD (HR 1.23, 95% CI 1.02–1.49). In sensitivity analyses, the risk for ESKD was reduced. Subgroup analysis showed that the risk of mortality was more pronounced in patients with eGFR above 30 mL/min/m<sup>2</sup> and in patients with hyperkalemia-related discontinuation. In contrast, patients with eGFR below 30 mL/min/m<sup>2</sup> were at great risk of cardiovascular events. <b><i>Conclusions:</i></b> The discontinuation of RAS inhibitors in patients with CKD was associated with a significantly increased risk of all-cause mortality and cardiovascular events. These data suggest that RAS inhibitors should be continued in CKD if the clinical situation allows.
DOI: 10.6084/m9.figshare.23617272
title: Supplementary Material for: Spinal Cord Stimulation for Parkinson’s Disease: A Systematic Review and Meta-Analysis of Pain and Motor Outcomes

description: <b><i>Background:</i></b> Spinal cord stimulation (SCS) has been investigated as a potential therapeutic option for managing refractory symptoms in patients with Parkinson’s disease (PD). <b><i>Objective:</i></b> This systematic review and meta-analysis aimed to evaluate the safety and efficacy of SCS in PD. <b><i>Method:</i></b> A comprehensive literature search was conducted on PubMed and Web of Science to identify SCS studies reporting Unified Parkinson Disease Rating Scale-III (UPDRS-III) or Visual Analogue Scale (VAS) score changes in PD cohorts with at least 3 patients and a follow-up period of at least 1 month. Treatment effect was measured as the mean change in outcome scores and analyzed using an inverse variance random-effects model. The risk of bias was assessed using the Newcastle-Ottawa Scale and funnel plots. <b><i>Results:</i></b> A total of 11 studies comprising 76 patients were included. Nine studies involving 72 patients reported an estimated decrease of 4.43 points (95% confidence interval [CI]: 2.11; 6.75, <i>p</i> &lt; 0.01) in UPDRS-III score, equivalent to a 14% reduction. The axial subscores in 48 patients decreased by 2.35 points (95% CI: 1.26; 3.45, <i>p</i> &lt; 0.01, 20% reduction). The pooled effect size of five studies on back and leg pain VAS scores was calculated as 4.38 (95% CI: 2.67; 6.09, <i>p</i> &lt; 0.001), equivalent to a 59% reduction. <b><i>Conclusions:</i></b> Our analysis suggests that SCS may provide significant motor and pain benefits for patients with PD, although the results should be interpreted with caution due to several potential limitations including study heterogeneity, open-label designs, small sample sizes, and the possibility of publication bias. Further research using larger sample sizes and placebo-/sham-controlled designs is needed to confirm effectiveness.
DOI: 10.6084/m9.figshare.24062265.v1
title: Data

description: All the data described for HIF 1 alpha, MMP-2 and eNOS.
DOI: 10.6084/m9.figshare.24271027
title: Supplementary Material for: Systemic type 2 inflammation associated atopic dermatitis exacerbates periodontitis

description: Introduction: Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin disease characterized by Th2 cell-mediated type 2 inflammation. Emerging evidence indicated that AD patients exhibit an increased incidence of oral disorders. In the present study, we sought mechanistic insights into how AD affects periodontitis. Methods: Onset of AD was induced by 2,4-dinitrochlorobenzene (DNCB). Furthermore, we induced periodontitis (P) in AD mice. The effect of AD in promoting inflammation and bone resorption in gingiva was evaluated. Hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase staining, immunofluorescence assay, and flow cytometry were used to investigate histomorphology, and cytology analysis, respectively. RNA sequencing (RNAseq) of oral mucosa tissues to further understand the dynamic transcriptome changes. 16S rRNA microbial analysis is used to profile oral microbial composition. Results: Compared control group, mice in AD group showed inflammatory signatures and infiltration of a proallergic Th2 (Th2A)-like subset in oral mucosa, but not periodontitis, identified by not substantial changes in mucosa swelling, alveolar bone loss and TRAP+ osteoclasts infiltration. Similarly, more Th2A-like cell infiltration and IL-4 levels were significantly elevated in the oral mucosa of DNCB-P mice compared to P mice. More importantly, AD exacerbates periodontitis when periodontitis has occurred and the severity of periodontitis increased with aggravation of dermatitis. Transcriptional analysis revealed that aggravated periodontitis was positively correlated with more macrophage infiltration and abundant CCL3 secreted. AD also altered oral microbiota, indicating the re-organization of extracellular matrix. Conclusions: These data provide a solid evidence about exacerbation of periodontitis caused by type 2 dermatitis, advancing our understanding in cellular and microbial changes during AD-periodontitis progression.
DOI: 10.18141/1432658
title: Imaging Techniques for Analyzing Shale Pores and Minerals

description: Carbon Storage TRS
DOI: 10.5281/zenodo.7074990
title: Using spectral reflectance and random forest method for modeling soil surface changes induced by simulated rainfall - datasets

description: Using spectral reflectance and random forest method for modeling soil surface changes induced by simulated rainfall - datasets The impact of simulated rainfall on the soil surface roughness of different soil types with various initial surface states and the differences between their spectral characteristics were studied under laboratory conditions. The soil samples were collected from a horizon of fields near Poznań, western Poland. The physical and physicochemical properties of each soil sample were determined. Then, the part of the soil materials, consisting of natural aggregates, were used to form three soil surface roughness. An explanation of the table column names in the “soils properties.csv” file: “textural classification” - Name of the granulometric group. Soil texture was determined by the hydrometer method according to standard PN-R-04032. “sand” - Sand content in the soil sample in %. “silt” – Silt content in the soil sample in %. “clay” – Clay content in the soil sample in %. pHH2O” - The pH of the soil sample determined in water. The soil pH was determined by the potentiometry method. “pHKCl” – The pH of the soil sample determined in KCl. The soil pH was determined by the potentiometry method. “SOC” – Organic matter content in soil was determined by oxidation titration using K2Cr2O7 with H2SO4 on the block mineralization. An explanation of the table column names in the “rainfall doses.csv” file: “rainfall simulation” - Rainfall simulation number. “rainfall dose” - One-time amount of rainfall dose expressed in millimeters. “accumulated rainfall” – Summation of rainfall after each successive dose expressed in millimeters. An explanation of the table column names in the “soil measurements” file: “textural classification” - Name of the granulometric group. Soil texture was determined by the hydrometer method according to standard PN-R-04032. “rainfall simulation” - Rainfall simulation number. “reflectance” - The amount of radiation reflected from the soil surface under the influence of successive rainfalls and expressed in nanometres. “roughness state” - The size of the roughness: R1 is the lowest soil roughness state, R2 represents medium soil roughness, and R3 represents the greatest roughness. “T3D” - Tortuosity index is a surface roughness index. It was calculated from DEM (Digital Elevation Model). It expresses the ratio between the true surface of DEM and its flat horizontal area. “HSD” - Height Standard Deviation is the second surface roughness index. It was calculated from DEM and expressed in millimeters. <br>
DOI: 10.5281/zenodo.7607351
title: Underlying data for The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study

description: Underlying data for The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study
DOI: 10.5281/zenodo.7607382
title: STROBE checklist for: The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study

description: STROBE checklist for: The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study
DOI: 10.6084/m9.figshare.22139840
title: Supplementary Material for: Enhanced Parenteral Nutrition Is Feasible and Safe in Very Low Birth Weight Preterm Infants: A Randomized Trial

description: <b><i>Objective:</i></b> The objective of this study was to determine the feasibility and safety of enhanced early (PN) (early initiation of intralipids and faster advancement of glucose infusion rate) during the first week of life for very low birth weight (VLBW) preterm infants. <b><i>Methods:</i></b> 90 VLBW preterm infants (&lt;32 weeks gestational age at birth) admitted to the University of Minnesota Masonic Children’s Hospital between August 2017 and June 2019 were included. Enrolled infants were stratified by gestational age-groups and randomized to either the enhanced nutrition protocol (intervention group) or the standard PN protocol (standard group). Welch’s two-sample <i>t</i> tests were used to investigate differences in calorie and protein intake, insulin use, days of hyperglycemia, hyperbilirubinemia, and hypertriglyceridemia, and proportion of bronchopulmonary dysplasia, necrotizing enterocolitis, and death between groups. <b><i>Results:</i></b> Intervention and standard groups were similar in baseline characteristics. The intervention group received higher weekly mean caloric intake (102.6 [SD 24.9] kcal/kg/day versus 89.7 [SD 30.2] kcal/kg/day; <i>p</i> = 0.001) and higher mean caloric intake on days of life 2–4 (<i>p</i> &lt; 0.05 for all). Both groups received the recommended protein intake (≥4 g/kg/day). There were no significant differences in safety or feasibility outcomes between groups (all <i>p</i> values &gt;0.12). <b><i>Conclusion:</i></b> Utilization of an enhanced nutrition protocol during the first week of life resulted in increased caloric intake and was feasible with no evidence of harm. Follow-up of this cohort is needed to determine if enhanced PN will result in improved growth and neurodevelopment.
DOI: 10.6084/m9.figshare.22352932
title: Supplementary Material for: Predictive Factors for Gleason Score Upgrading in Patients with Prostate Cancer after Radical Prostatectomy: A Systematic Review and Meta-Analysis

description: <b><i>Introduction:</i></b> Previous studies have revealed that Gleason score upgrading (GSU) was closely related to an increased biochemical recurrence rate and adverse oncologic outcomes in patients with prostate cancer (PC). Therefore, we performed a meta-analysis to determine the predictive factors for GSU following radical prostatectomy (RP). <b><i>Methods:</i></b> We performed an extensive literature search using PubMed, Embase, and Cochrane in September 2022. In order to calculate the pooled odds ratio (OR), standardized mean difference (SMD), and 95% confidence intervals, a fixed effect or a DerSimonian and Laird random effect was applied. <b><i>Results:</i></b> Twenty-six studies included 18,745 PC patients that were available for further analysis. Our results revealed that GSU was significantly correlated with age (summary SMD = 0.13; <i>p</i> = 0.004), prostate volume (PV) (summary SMD = −0.19;<i>p</i> &lt; 0.001), preoperative PSA (p-PSA) (summary SMD = 0.18; <i>p</i> &lt; 0.001), PSA density (PSAD) (summary SMD = 0.40; <i>p</i> &lt; 0.001), number of positive cores (summary SMD = 0.28; <i>p</i> = 0.001), percentage of positive cores (summary SMD = 0.36; <i>p</i> &lt; 0.001), Prostate Imaging Reporting and Data System (PI-RADS) scores (&gt;3/≤3) (summary OR = 2.27; <i>p</i> = 0.001), clinical T stage (&gt;T2/≤T2) (summary OR = 1.73; <i>p</i> &lt; 0.001), positive surgical margins (PSM) (summary OR = 2.12; <i>p</i> &lt; 0.001), extraprostatic extension (EPE) (summary OR = 2.73; <i>p</i> &lt; 0.001), pathological T stage (&gt;T2/≤T2) (summary OR = 3.45; <i>p</i> &lt; 0.001), perineural invasion (PNI) (summary OR = 2.40; <i>p</i> = 0.008), and neutrophil to lymphocyte ratio (NLR) (summary SMD = 0.50; <i>p</i> &lt; 0.001). However, we found that GSU was not significantly correlated with body mass index (BMI) (summary SMD = −0.02; <i>p</i> = 0.602). Moreover, our sensitivity and subgroup analyses showed that the findings were reliable. <b><i>Conclusions:</i></b> Age, PV, p-PSA, PSAD, number of positive cores, percentage of positive cores, PI-RADS score, clinical T stage, PSM, EPE, pathological T stage, PNI, and NLR are independent factors predicting GSU following RP. The findings may be helpful in risk stratification and personalized treatment in PC patients.
DOI: 10.6084/m9.figshare.23551920
title: Supplementary Material for: Assessing the clinical and endoscopic efficacy of extended duration treatment with different doses of mesalazine for mild to moderate ulcerative colitis beyond 8 weeks of induction

description: Introduction: High-strength mesalazine formulations play an important role in providing a convenient option to increase the dose in ulcerative colitis (UC) patients and therefore avoiding the switch to another therapeutic class. Higher doses of mesalazine may be required during periods of remission in order to prevent relapse. Aim: To investigate clinical outcomes of three mesalazine maintenance doses adapted for post induction response. Methods: In this post-hoc analysis, 675 UC patients entered an open label extension study for a total of 38 weeks (including 8-12 week induction period with 3.2 g/day mesalazine). After the induction period they were separated into three groups: remitters (in clinical and endoscopic remission), responders (decrease in Partial Mayo Clinic Score (PMCS) of ≥ 2 points and ≥ 30% from week 0) and non-responders (failed to achieve endoscopic and clinical response at week 8) and received 1.6 g/day, 3.2 g/day or 4.8 g/day of mesalazine (using a new 1600 mg mesalazine tablet), respectively. Results: 133/202 (65.8%), 108/274 (39.4%) and 59/199 (29.6%) patients achieved clinical and endoscopic remission at week 38 with 1.6 g/day, 3.2 g/day and 4.8 g/day, respectively. At week 38, 142/202 (70.3%), 93/274 (33.9%) and 61/199 (30.7%) patients achieved clinical remission (stool score of 0 and rectal bleeding score of 0) with 1.6 g/day, 3.2 g/day and 4.8 g/day, respectively. Conclusions: Patients partially responding or not responding to an initial induction dose of 3.2 g/day mesalazine could benefit from an extended treatment period at the same dose, or an increase to 4.8 g/day in an attempt to achieve combined clinical and endoscopic remission.
DOI: 10.5281/zenodo.254283
title: Phoshorene Solvated In [Emim][Bf4]. Force Field Files And Md Systems

description: Phoshorene Solvated in [EMIM][BF4]. Force field files and MD systems
DOI: 10.6084/m9.figshare.20183354.v1
title: McGregor_et_al_Figure_4_Source_data_1.mat

description: Data for producing Figure 4b from Shared mechanisms of auditory and non-auditory vocal learning in the songbird brain.
DOI: 10.6084/m9.figshare.23266070
title: Supplementary Material for: Evaluation of a dementia training course for staff of a center of dementia care

description: Introduction: Literature shows poor dementia training and competencies among health and social professionals. Due to the growing prevalence of people with dementia and all the related care demands, specialized training is increasingly needed but must be effective in terms of impact on knowledge, behaviours and attitudes. We aimed to analyse the impact of a first-level dementia training course for staff of a new specialized center for people with dementia, considering the first three levels of Kirkpatrick’s evaluation framework, namely staff reaction (satisfaction), skills and learning (knowledge and dementia attitudes), and behaviour changes. Methods: Single-center group pre-post design study of a 12-session online course. An online questionnaire was administered to measure satisfaction, expectations, knowledge/learning, attitudes (Dementia Attitude Scale) and new behaviours/practices. We compared perceived knowledge (Wilcoxon signed-rank test) and attitudes (paired T-test). Thematic analysis explored new behaviours/practices. Results: 85 professionals and 1 volunteer were included (median age 31, 92% female). Satisfaction with the training was high (median 4/5). Perceived knowledge improved (median 3 to 4; p˂0.001). The knowledge test median score was 70.8%. After training, participants showed better attitudes towards dementia (mean 116.5, SD 10.3 to mean 122.2, SD 11.5; p˂0.001). Most (93%) said their behaviour/practice changed. Thematic analysis yielded four new behaviour/practice dimensions: knowledge, care provision/interaction, communication, family/caregivers, self-confidence and importance of physical environment. Conclusions: The course improved all dimensions evaluated, suggesting it effectively provides first-level dementia training. This may be transferable to similar settings.
DOI: 10.6084/m9.figshare.23507037
title: Supplementary Material for: Endotyping Difficult-to-Treat Chronic Rhinosinusitis with Nasal Polyps by Structured Histopathology

description: <b><i>Introduction:</i></b> This study aimed to identify the histopathologic characteristics associated with difficult-to-treat chronic rhinosinusitis with nasal polyps (CRSwNPs), enabling physicians to predict the risk of poor outcome after endoscopic sinus surgery (ESS). <b><i>Methods:</i></b> A prospective cohort study performed at the First Affiliated Hospital of Sun Yat-sen University between January 2015 and December 2018 with CRSwNP patients who underwent ESS. Polyp specimens were collected during surgery and were subjected to structured histopathological evaluation. Difficult-to-treat CRSwNPs were determined at 12–15 months post-operation according to the European Position Paper. Multiple logistic regression model was used to assess the association between histopathological parameters and the difficult-to-treat CRSwNP. <b><i>Results:</i></b> Among 174 subjects included in the analysis, 49 (28.2%) were classified with difficult-to-treat CRSwNP, which had higher numbers of total inflammatory cells, tissue eosinophils, and percentages of eosinophil aggregates and Charcot-Leyden crystals (CLC) formation but a lower number of interstitial glands than the nondifficult-to-treat CRSwNP. Inflammatory cell infiltration (adjusted OR: 1.017), tissue eosinophilia (adjusted OR: 1.005), eosinophil aggregation (adjusted OR: 3.536), and CLC formation (adjusted OR: 6.972) were independently associated with the difficult-to-treat outcome. Furthermore, patients with tissue eosinophil aggregation and CLC formation had an increasingly higher likelihood of uncontrolled disease versus those with tissue eosinophilia. <b><i>Conclusion:</i></b> The difficult-to-treat CRSwNP appears to be characterized by increased total inflammatory infiltrates, tissue eosinophilia, eosinophil aggregation, and CLC formation in structured histopathology.
DOI: 10.6084/m9.figshare.24188241.v1
title: Dataset for "A Statistical Study on the Acceleration Conditions of Ultra-relativistic Electrons in the Earth’s Outer Radiation Belt During Geomagnetic Storms"

description: This is the dataset used to produce figures for the paper under review with the title of "A Statistical Study on the Acceleration Conditions of Ultrarelativistic Electrons in the Earth’s Outer Radiation Belt During Geomagnetic Storms"
DOI: 10.1285/i15900932v32n2p141
title: On Certain Fractional Differential Equations Involving Generalized Multivariable Mittag � Leffler Function

description: In this paper some fractional differential equations are solved by using the Laplace transform method. These fractional differential equations with Riemann � Liouville fractional derivative operators are very general in nature and involve the wide range of fractional differential equations and their solutions in terms of various functions related to Mittag � Leffler function