cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21505918
title: Automated documentation of vital parameters in wards using portable stations - Effect on proper triggering of the rapid response team: a study protocol of a cluster randomized clinical trial

description: ABSTRACT Objective: To evaluate the effectiveness of the Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ solution in activating the rapid response team in a timely manner compared to manual activation. Methods: The Hillrom study is a single-center, open-label, superiority, cluster-randomized, parallel-group (1:1 allocation ratio) clinical trial that will be conducted in a tertiary hospital. Two sets of three wards with 28 beds will be included (one as the intervention cluster and the other as the control). The wards will be randomly assigned to use the Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ automated solution (intervention cluster) or to maintain the usual routine (control cluster) regarding rapid response team activation. The primary outcome will be the absolute number of episodes of rapid response team triggering in an appropriate time; as secondary outcomes, clinical features (mortality, cardiac arrest, need for intensive care unit admission and duration of hospitalization) will be assessed according to clusters in an exploratory way. A sample size of 216 rapid response team activations was estimated to identify a possible difference between the groups. The protocol has been approved by the institutional Research Ethics Committee. Expected results: The Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ automated solution is expected to be more effective in triggering the nurse call system to activate the rapid response team in a timely and adequate manner compared to manual triggering (usual practice). ClinicalTrials.gov: NCT04648579
DOI: 10.6084/m9.figshare.21505918.v1
title: Automated documentation of vital parameters in wards using portable stations - Effect on proper triggering of the rapid response team: a study protocol of a cluster randomized clinical trial

description: ABSTRACT Objective: To evaluate the effectiveness of the Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ solution in activating the rapid response team in a timely manner compared to manual activation. Methods: The Hillrom study is a single-center, open-label, superiority, cluster-randomized, parallel-group (1:1 allocation ratio) clinical trial that will be conducted in a tertiary hospital. Two sets of three wards with 28 beds will be included (one as the intervention cluster and the other as the control). The wards will be randomly assigned to use the Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ automated solution (intervention cluster) or to maintain the usual routine (control cluster) regarding rapid response team activation. The primary outcome will be the absolute number of episodes of rapid response team triggering in an appropriate time; as secondary outcomes, clinical features (mortality, cardiac arrest, need for intensive care unit admission and duration of hospitalization) will be assessed according to clusters in an exploratory way. A sample size of 216 rapid response team activations was estimated to identify a possible difference between the groups. The protocol has been approved by the institutional Research Ethics Committee. Expected results: The Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ automated solution is expected to be more effective in triggering the nurse call system to activate the rapid response team in a timely and adequate manner compared to manual triggering (usual practice). ClinicalTrials.gov: NCT04648579
DOI: 10.6084/m9.figshare.21456342.v1
title: Seed dispersal of the mushroom-like, non-photosynthetic plant Balanophora by the Amami rabbit Pentalagus furnessi

description: Dateset of ”Seed dispersal of the mushroom-like, non-photosynthetic plant Balanophora by the Amami rabbit Pentalagus furnessi”
DOI: 10.6084/m9.figshare.21505921.v1
title: In vivo antimalarial activity of self-nanoemulsifying drug delivery systems containing ethanolic extract of Morinda lucida in combination with other Congolese plants extracts

description: Abstract Morinda lucida leaves are largely used by Congolese traditional healers for the treatment of uncomplicated malaria. The antimalarial activity of their ethanolic extract has been confirmed both in vitro and in vivo. However, the development of relevant formulations for potential clinical application is hampered since the active ingredients contained in this extract exhibit poor water solubility and low oral bioavailability. Hence, this work aims not only to develop self-nanoemulsifying drug delivery systems (SNEDDSs) for oral delivery of the ethanolic extract of Morinda lucida (ML) but also to evaluate its oral antimalarial activity alone and in combination with other Congolese ethanolic plant extracts (Alstonia congensis, Garcinia kola, Lantana camara, Morinda morindoides or Newbouldia laevis). Based on the solubility of these different extracts in various excipients, SNEDDS preconcentrates were prepared, and 200 mg/g of each plant extract were suspended in these formulations. The 4-day suppressive Peter’s test revealed a significant parasite growth inhibiting effect for all the extract-based SNEDDS (from 55.0 to 82.4 %) at 200 mg/kg. These activities were higher than those of their corresponding ethanolic suspensions given orally at the same dose (p&lt;0.05). The combination therapy of MLSNEDDS with other extract-based SNEDDS exhibited remarkable chemosuppression, ranging from 74.3 % to 95.8 % (for 100 + 100 mg/kg) and 86.7 % to 95.5 % (for 200 + 200 mg/kg/day). In regard to these findings, SNEDDS suspension may constitute a promising approach for oral delivery of ML alone or in combination with other antimalarial plants.
DOI: 10.6084/m9.figshare.21505921
title: In vivo antimalarial activity of self-nanoemulsifying drug delivery systems containing ethanolic extract of Morinda lucida in combination with other Congolese plants extracts

description: Abstract Morinda lucida leaves are largely used by Congolese traditional healers for the treatment of uncomplicated malaria. The antimalarial activity of their ethanolic extract has been confirmed both in vitro and in vivo. However, the development of relevant formulations for potential clinical application is hampered since the active ingredients contained in this extract exhibit poor water solubility and low oral bioavailability. Hence, this work aims not only to develop self-nanoemulsifying drug delivery systems (SNEDDSs) for oral delivery of the ethanolic extract of Morinda lucida (ML) but also to evaluate its oral antimalarial activity alone and in combination with other Congolese ethanolic plant extracts (Alstonia congensis, Garcinia kola, Lantana camara, Morinda morindoides or Newbouldia laevis). Based on the solubility of these different extracts in various excipients, SNEDDS preconcentrates were prepared, and 200 mg/g of each plant extract were suspended in these formulations. The 4-day suppressive Peter’s test revealed a significant parasite growth inhibiting effect for all the extract-based SNEDDS (from 55.0 to 82.4 %) at 200 mg/kg. These activities were higher than those of their corresponding ethanolic suspensions given orally at the same dose (p&lt;0.05). The combination therapy of MLSNEDDS with other extract-based SNEDDS exhibited remarkable chemosuppression, ranging from 74.3 % to 95.8 % (for 100 + 100 mg/kg) and 86.7 % to 95.5 % (for 200 + 200 mg/kg/day). In regard to these findings, SNEDDS suspension may constitute a promising approach for oral delivery of ML alone or in combination with other antimalarial plants.
DOI: 10.6084/m9.figshare.21505922
title: Sustained release matrix tablet of 100 mg losartan potassium: Formulation development and in vitro characterization

description: Abstract Sustained release matrix tablets of 100 mg losartan potassium HCl were fabricated with two release retarding polymers namely HPMC K100 M and affinisol by direct compression method. Nine trial formulations were prepared by varying content of these polymers, each from 50 mg to 100 mg; keeping the total weight of the tablet 310 mg. The best formulation was selected based on in vitro drug release profile for 12 hours conducted in Type II dissolution apparatus at 50 rpm and water as dissolution medium. Pre-compression parameters such as bulk density, tap density, Carr’s index and Hausner ratio were evaluated for the selected tablet. The tablets were subjected to thickness, weight variation test, drug content, hardness and friability. Drug release kinetics, surface morphology and accelerated stability study were investigated for that selected formulation. Formulation F4 with the composition of 75 mg HPMC K100M and 100 mg affinisol was selected as the best formulation that extended the drug release up to 12 hours. Pre-compression parameters and other tableting properties were within the Pharmacopoeia limit. Release kinetics analysis proved non-fickian zero-order drug release and that was further confirmed by surface morphology of the tablets before and after dissolution study visualized by SEM. The developed formulation was found to be stable for one month stored at 60 ○C.
DOI: 10.5281/zenodo.7294305
title: Error

description: Error.
DOI: 10.5281/zenodo.7294306
title: Statistical analysis for biogeochemical processes in a sandy column with dynamic hydrologic regimes using spectral induced polarization (SIP) and self-potential (SP)

description: Dataset for the manuscript: Statistical analysis for biogeochemical processes in a sandy column with dynamic hydrologic regimes using spectral induced polarization (SIP) and self-potential (SP).
DOI: 10.5281/zenodo.7294320
title: Error

description: Error.
DOI: 10.6084/m9.figshare.21505925
title: The residential real estate production in the São José do Rio Preto region 2000-2019: a view from Minha Casa Minha Vida Program

description: Abstract In contrast to what we are used to see in urban studies of big cities - here specially considered the city of São Paulo -, the small and medium-sized cities in São Paulo’s hinterland have been exhibiting, in the last two decades, a notable real estate production, characterized by an overproduction based in the mismatch between the real estate numbers and the effective demand for housing. Some of the characteristics of these countryside cities, especially those that conform regional centers, corroborate to the constitution of their territories as an attractive area to the implementation of new housing products, both in form of urban allotments production and in low-income habitational developments promoted by the Minha Casa Minha Vida Program. This article aims to analyze the aspects that contribute to the conformation of such a singular production in these cities, using, for this purpose, the study of the Minha Casa Minha Vida Program real estate production in São José do Rio Preto and neighboring municipalities, which stands out due to the expressive production in comparation to the other cities in São Paulo.
DOI: 10.6084/m9.figshare.21505925.v1
title: The residential real estate production in the São José do Rio Preto region 2000-2019: a view from Minha Casa Minha Vida Program

description: Abstract In contrast to what we are used to see in urban studies of big cities - here specially considered the city of São Paulo -, the small and medium-sized cities in São Paulo’s hinterland have been exhibiting, in the last two decades, a notable real estate production, characterized by an overproduction based in the mismatch between the real estate numbers and the effective demand for housing. Some of the characteristics of these countryside cities, especially those that conform regional centers, corroborate to the constitution of their territories as an attractive area to the implementation of new housing products, both in form of urban allotments production and in low-income habitational developments promoted by the Minha Casa Minha Vida Program. This article aims to analyze the aspects that contribute to the conformation of such a singular production in these cities, using, for this purpose, the study of the Minha Casa Minha Vida Program real estate production in São José do Rio Preto and neighboring municipalities, which stands out due to the expressive production in comparation to the other cities in São Paulo.
DOI: 10.6084/m9.figshare.21505931
title: Faces of biphobia inside (and outside) the LGBTQIAP+ community: reflections from bisexual people's narratives

description: Abstract: The aim of this article is to investigate the different manifestations of biphobia, especially within the LGBTQIAP+ community. For this purpose, a survey was carried out with six bisexual people, whose reports were submitted to content analysis. The results show that biphobia manifests itself in aspects such as the hypersexualization of bisexuals and the pressure to choose a “definitive” sexual orientation. We argue that bisexual people face difficulties to be embraced by the LGBTQIAP+ community, as their affective/sexual practices are considered illegitimate and their experiences tend to be invalidated. This context of exclusion aggravates feelings such as loneliness and identity confusion. Thus, the bisexual people face a particular dynamic of violence that produces relevant effects on their mental health.
DOI: 10.6084/m9.figshare.21505931.v1
title: Faces of biphobia inside (and outside) the LGBTQIAP+ community: reflections from bisexual people's narratives

description: Abstract: The aim of this article is to investigate the different manifestations of biphobia, especially within the LGBTQIAP+ community. For this purpose, a survey was carried out with six bisexual people, whose reports were submitted to content analysis. The results show that biphobia manifests itself in aspects such as the hypersexualization of bisexuals and the pressure to choose a “definitive” sexual orientation. We argue that bisexual people face difficulties to be embraced by the LGBTQIAP+ community, as their affective/sexual practices are considered illegitimate and their experiences tend to be invalidated. This context of exclusion aggravates feelings such as loneliness and identity confusion. Thus, the bisexual people face a particular dynamic of violence that produces relevant effects on their mental health.
DOI: 10.6084/m9.figshare.21505934
title: Lacrimal gland pleomorphic adenoma: a narrative review

description: ABSTRACT We present a literature review of 57 publications describing this pathology, published from the year 2012. In all these studies patients were reported to depict a slow-growing, motionless mass, which is painless at most times. All cases were managed by total excision, except for one report where adjuvant radiotherapy was applied. Among the several therapeutic strategies, the total tumor resection, preserving the tumor pseudocapsule intact, appears to be a consensus in treating the disease efficiently. Furthermore, fine-needle aspiration biopsy, including the assessment of genetic alterations, has proved to be a valuable tool in the diagnosis of challenging cases. Our literature survey also suggests that an incisional biopsy before the surgery may lead to the pseudocapsule disruption, thus considerably increasing the chances of adenoma recurrence, enabling its malignization. At present, genetics studies indicate that the molecular aberrations involved in the adenoma are similar to those represented in the salivary gland tumor pathogenesis. Further, in the recurrent cases, the pathology becomes difficult to treat and multiple surgeries may be required, occasionally, leading to radical surgery treatment.
DOI: 10.6084/m9.figshare.21505934.v1
title: Lacrimal gland pleomorphic adenoma: a narrative review

description: ABSTRACT We present a literature review of 57 publications describing this pathology, published from the year 2012. In all these studies patients were reported to depict a slow-growing, motionless mass, which is painless at most times. All cases were managed by total excision, except for one report where adjuvant radiotherapy was applied. Among the several therapeutic strategies, the total tumor resection, preserving the tumor pseudocapsule intact, appears to be a consensus in treating the disease efficiently. Furthermore, fine-needle aspiration biopsy, including the assessment of genetic alterations, has proved to be a valuable tool in the diagnosis of challenging cases. Our literature survey also suggests that an incisional biopsy before the surgery may lead to the pseudocapsule disruption, thus considerably increasing the chances of adenoma recurrence, enabling its malignization. At present, genetics studies indicate that the molecular aberrations involved in the adenoma are similar to those represented in the salivary gland tumor pathogenesis. Further, in the recurrent cases, the pathology becomes difficult to treat and multiple surgeries may be required, occasionally, leading to radical surgery treatment.
DOI: 10.6084/m9.figshare.21505936
title: Shape the Enterprise, Shape the Life: Strategy of Living Life in Refuge as an Ethnic Entrepreneur in Light of Immaterial Labor

description: Abstract This article aims to present and analyze the strategy for living life of Syrian refugees, examining the ethnic enterprise in light of the notion of immaterial labor. A qualitative and exploratory study was conducted in the city of Porto Alegre (Brazil), based on a corpus of research whose thematic focus was ethnicity in the food-sector enterprises of Syrian refugees. The data were accessed by means of newspaper reports, visits to the enterprises, the consumption of products, narrative interviews, and direct observation with photographic and field diary records. The participants were Syrian refugees interconnected through family ties and a common origin who share two enterprises – an ethnic snack bar and confectionery. The analysis resulted in three axes: (a) routes and obstacles in refuge; (b) immaterial labor in the ethnic enterprise; and (c) being an ethnic entrepreneur as a strategy for living life in refuge. It is highlighted that the metaphorical models of wanderer and player help to illustrate the production of subjectivity outlining the ethnic entrepreneur as a strategy for living life as a refugee operationalized by immaterial labor. These conclusions provide an analytical perspective on the subjectivity for ethnic enterprises by showing that the ethnic entrepreneur in correspondence with the self-entrepreneur in immaterial labor operates in the sense of producing/composing/affirming the strategy for living life in refuge. Thus, by shaping the enterprise, it shapes the life.
DOI: 10.6084/m9.figshare.21505936.v1
title: Shape the Enterprise, Shape the Life: Strategy of Living Life in Refuge as an Ethnic Entrepreneur in Light of Immaterial Labor

description: Abstract This article aims to present and analyze the strategy for living life of Syrian refugees, examining the ethnic enterprise in light of the notion of immaterial labor. A qualitative and exploratory study was conducted in the city of Porto Alegre (Brazil), based on a corpus of research whose thematic focus was ethnicity in the food-sector enterprises of Syrian refugees. The data were accessed by means of newspaper reports, visits to the enterprises, the consumption of products, narrative interviews, and direct observation with photographic and field diary records. The participants were Syrian refugees interconnected through family ties and a common origin who share two enterprises – an ethnic snack bar and confectionery. The analysis resulted in three axes: (a) routes and obstacles in refuge; (b) immaterial labor in the ethnic enterprise; and (c) being an ethnic entrepreneur as a strategy for living life in refuge. It is highlighted that the metaphorical models of wanderer and player help to illustrate the production of subjectivity outlining the ethnic entrepreneur as a strategy for living life as a refugee operationalized by immaterial labor. These conclusions provide an analytical perspective on the subjectivity for ethnic enterprises by showing that the ethnic entrepreneur in correspondence with the self-entrepreneur in immaterial labor operates in the sense of producing/composing/affirming the strategy for living life in refuge. Thus, by shaping the enterprise, it shapes the life.
DOI: 10.6084/m9.figshare.21505940
title: Neonatal hearing screening programs: quality indicators and access to health services

description: Abstract Objectives: to verify the quality indicators of neonatal hearing screening programs, identify the most prevalent risk factors for hearing loss and analyze access to the Hearing Health Care Network. Methods: cross-sectional study using secondary data. The population are children born in public maternity hospitals from 2015 to 2019. Data collection was carried out in the database of programs and hearing health service. The absolute and relative frequencies of all variables collected and the median, the interquartile range and the Mann-Whitney test were calculated to analyze the access. Results: universality increased during the study period, but was not reached (71.9%; CI95%=70.4-73.3) and the referral rate for auditory diagnosis was within the recommended range (0.9%; CI95%=0.8-0.9). The most prevalent risk factors were congenital infections and heredity. There was an evasion of children to the hearing health service of 85.1% and the type of referral interfered with the age of the child at access. Eight children with hearing loss were diagnosed, in which seven had access to therapeutic interventions. Conclusions: hearing screening was not universal. Access to the Hearing Health Care Network presents high evasion and interventions were offered to children with hearing loss.
DOI: 10.6084/m9.figshare.21505940.v1
title: Neonatal hearing screening programs: quality indicators and access to health services

description: Abstract Objectives: to verify the quality indicators of neonatal hearing screening programs, identify the most prevalent risk factors for hearing loss and analyze access to the Hearing Health Care Network. Methods: cross-sectional study using secondary data. The population are children born in public maternity hospitals from 2015 to 2019. Data collection was carried out in the database of programs and hearing health service. The absolute and relative frequencies of all variables collected and the median, the interquartile range and the Mann-Whitney test were calculated to analyze the access. Results: universality increased during the study period, but was not reached (71.9%; CI95%=70.4-73.3) and the referral rate for auditory diagnosis was within the recommended range (0.9%; CI95%=0.8-0.9). The most prevalent risk factors were congenital infections and heredity. There was an evasion of children to the hearing health service of 85.1% and the type of referral interfered with the age of the child at access. Eight children with hearing loss were diagnosed, in which seven had access to therapeutic interventions. Conclusions: hearing screening was not universal. Access to the Hearing Health Care Network presents high evasion and interventions were offered to children with hearing loss.