cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5285/4a0e4a75-fdc6-45b1-a72a-f517164bb147
title: Experimental work on Ivrea ultramafic pipe material

description: Results of piston cylinder experiments on lower-crustal material from the Ivrea Zone, Italian Alps. Natural sulfides and sulfide-silicate mixes from lower crustal cumulates were heated and pressurised to conditions matching those of the MASH zone, which is hypothesised to be the source of metals for post-collisional porphyry Cu deposits. This was done in order to simulate partial melting and examine the mobility of metals in this environment. This data contains experimental logs stating the experimental conditions; reflected light photographs of the experimental capsules; scanning electron microscope element maps and identification of platinum group minerals and precious metal minerals in the capsules; and trace element concentration of sulfides in the capsules. This data was collected as part of the TeaSe consortium NERC grant in order to test hypotheses about porphyry Cu deposit formation. This data was collected by researchers at Cardiff University and the University of Edinburgh.
DOI: 10.5517/ccdc.csd.cc242rtt
title: CCDC 1968866: Experimental Crystal Structure Determination

description: Related Article: Matthieu Autillo, Md. Ashraful Islam, Julie Jung, Julien Pilmé, Nicolas Galland, Laetitia Guerin, Philippe Moisy, Claude Berthon, Christelle Tamain, Hélène Bolvin|2020|Phys.Chem.Chem.Phys.(PCCP)|22|14293|doi:10.1039/D0CP02137G
DOI: 10.5517/ccdc.csd.cc25jznc
title: CCDC 2012323: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Russell P. Hughes|2020|CSD Communication|||
DOI: 10.23636/1170
title: Sir Hans Sloane's Catalogues of his Library and Manuscripts

description: The files in this dataset are derived from microfilm copies of the original library catalogue of Sir Hans Sloane, now presented across 9 volumes, Sloane MS 3972 C 1-8, and the name index to the Sloane library catalogue, Sloane MS 3972 D. The catalogues are crucial for understanding the development of Sloane's collections, the present-day collections of the British Library, British Museum and Natural History Museum, and to identifying collection items which are now dispersed across a number of institutions.
DOI: 10.5517/ccdc.csd.cc24xxpp
title: CCDC 1994003: Experimental Crystal Structure Determination

description: Related Article: Tuan K. Nguyen, Gleb D. Titov, Olesya V. Khoroshilova, Mikhail A. Kinzhalov, Nikolai V. Rostovskii|2020|Org.Biomol.Chem.|18|4971|doi:10.1039/D0OB00693A
DOI: 10.5517/ccdc.csd.cc24xxrr
title: CCDC 1994005: Experimental Crystal Structure Determination

description: Related Article: Tuan K. Nguyen, Gleb D. Titov, Olesya V. Khoroshilova, Mikhail A. Kinzhalov, Nikolai V. Rostovskii|2020|Org.Biomol.Chem.|18|4971|doi:10.1039/D0OB00693A
DOI: 10.5517/ccdc.csd.cc2431kw
title: CCDC 1969137: Experimental Crystal Structure Determination

description: Related Article: Yuan Huang, Jia-Xin Li, Yu Ge, Xia-Mei Zhang, Yang Xu, Yahong Li, Yi-Quan Zhang, Jin-Lei Yao|2020|Dalton Trans.|49|8976|doi:10.1039/D0DT01619E
DOI: 10.5517/ccdc.csd.cc25218l
title: CCDC 1997958: Experimental Crystal Structure Determination

description: Related Article: Fateme Banihashemi, Guanhong Bu, Amar Thaker, Dewight Williams, Jerry Y.S. Lin, Brent L. Nannenga|2020|Ultramicroscopy|216|113048|doi:10.1016/j.ultramic.2020.113048
DOI: 10.5517/ccdc.csd.cc25jr6p
title: CCDC 2012092: Experimental Crystal Structure Determination

description: Related Article: Ralph A. Isovitsch, Frank R. Fronczek|2020|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc25jfy3
title: CCDC 2011805: Experimental Crystal Structure Determination

description: Related Article: Ralph A. Isovitsch, Frank R. Fronczek|2020|CSD Communication|||
DOI: 10.35013/z2z0-g483
title: Growth of American Families (GAF), 1955
DOI: 10.5517/ccdc.csd.cc20z1jl
title: CCDC 1875919: Experimental Crystal Structure Determination

description: Related Article: Bo Zhou, Qihang Zhao, Longchang Tang, Dongpeng Yan|2020|Chem.Commun.|56|7698|doi:10.1039/D0CC02730H
DOI: 10.35083/zfdd-cq08
title: Host Factor Experiment (EjuanesL_AUM_01_VE6_MA104_Expression)

description: Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-_E) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-_E attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, genes involved in signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cell cycle and differentiation were differentially regulated in cells infected with rSARS-CoV with or without the E gene. Administration of E protein in trans reduced the stress response in cells infected with rSARS-CoV-_E or with respiratory syncytial virus, or treated with drugs, such as tunicamycin and thapsigargin that elicit cell stress by different mechanisms. In addition, SARS-CoV E protein down-regulated the signaling pathway inositol-requiring enzyme 1 (IRE-1) of the unfolded protein response, but not the PKR-like ER kinase (PERK) or activating transcription factor 6 (ATF-6) pathways, and reduced cell apoptosis. Overall, the activation of the IRE-1 pathway was not able to restore cell homeostasis, and apoptosis was induced probably as a measure to protect the host by limiting virus production and dissemination. The expression of proinflammatory cytokines was reduced in rSARS-CoV-_E-infected cells compared to rSARS-CoV-infected cells, suggesting that the increase in stress responses and the reduction of inflammation in the absence of the E gene contributed to the attenuation of rSARS-CoV-_E.
DOI: 10.5517/ccdc.csd.cc23j594
title: CCDC 1951955: Experimental Crystal Structure Determination

description: Related Article: Debdeep Mandal, Felix Stein, Shubhadeep Chandra, Nicolás I. Neuman, Pallavi Sarkar, Shubhajit Das, Abhinanda Kundu, Arighna Sarkar, Hemant Rawat, Swapan K. Pati, Vadapalli Chandrasekhar, Biprajit Sarkar, Anukul Jana|2020|Chem.Commun.|56|8233|doi:10.1039/D0CC02807J
DOI: 10.5517/ccdc.csd.cc242rpp
title: CCDC 1968862: Experimental Crystal Structure Determination

description: Related Article: Matthieu Autillo, Md. Ashraful Islam, Julie Jung, Julien Pilmé, Nicolas Galland, Laetitia Guerin, Philippe Moisy, Claude Berthon, Christelle Tamain, Hélène Bolvin|2020|Phys.Chem.Chem.Phys.(PCCP)|22|14293|doi:10.1039/D0CP02137G
DOI: 10.5517/ccdc.csd.cc24n20x
title: CCDC 1985488: Experimental Crystal Structure Determination

description: Related Article: Sujaya Chakraborty, Somenath Lohar, Koushik Dhara, Raktim Ghosh, Somasri Dam, Ennio Zangrando, Pabitra Chattopadhyay|2020|Dalton Trans.|49|8991|doi:10.1039/D0DT01594F
DOI: 10.5517/ccdc.csd.cc23l6db
title: CCDC 1953911: Experimental Crystal Structure Determination

description: Related Article: Fabian A. D. Herz, Matthias Nobis, Daniel Wendel, Philipp Pahl, Philipp J. Altmann, Jan Tillmann, Richard Weidner, Shigeyoshi Inoue, Bernhard Rieger|2020|Green Chemistry|22|4489|doi:10.1039/D0GC00272K
DOI: 10.5517/ccdc.csd.cc2431jv
title: CCDC 1969136: Experimental Crystal Structure Determination

description: Related Article: Yuan Huang, Jia-Xin Li, Yu Ge, Xia-Mei Zhang, Yang Xu, Yahong Li, Yi-Quan Zhang, Jin-Lei Yao|2020|Dalton Trans.|49|8976|doi:10.1039/D0DT01619E
DOI: 10.35013/8w2e-q512
title: Political Elites in Mexico, 1900-1971
DOI: 10.5517/ccdc.csd.cc25jmly
title: CCDC 2011980: Experimental Crystal Structure Determination

description: Related Article: Kedar U Narvekar, Dinesh N. Nadimetala, Sheshanath V. Bhosale, Bikshandarkoil R Srinivasan|2020|CSD Communication|||
DOI: 10.35013/n4bm-zj05
title: Slave Movement -- Angola Slave Trade in the Eighteenth Century, 1723-1771
DOI: 10.5517/ccdc.csd.cc201q71
title: CCDC 1848692: Experimental Crystal Structure Determination

description: Related Article: Svetlana Pakhomova, Pramuditha Abhayawardhana, Luigi G. Marzilli, Frank R. Fronczek|2020|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc24wr3x
title: CCDC 1992869: Experimental Crystal Structure Determination

description: Related Article: Aleksandr A. Sapianik, Konstantin A. Kovalenko, Denis G. Samsonenko, Marina O. Barsukova, Danil N. Dybtsev, Vladimir P. Fedin|2020|Chem.Commun.|56|8241|doi:10.1039/D0CC03227A
DOI: 10.13023/hsgy-v728
title: Impacts of Larval Diet on Pre-Imaginal Development, Survival and Adult Size of Six Species of Coccinellidae

description: Compared larval development, survival, and adult size of six lady beetle species on a diet of aphids or moth eggs
description: © 2020 Nathan Mercer and John J. Obrycki
DOI: 10.5517/ccdc.csd.cc24x7r2
title: CCDC 1993354: Experimental Crystal Structure Determination

description: Related Article: Pierpaolo Morgante, Burjor Captain, Christopher D. Chouinard, Roberto Peverati, Norito Takenaka|2020|Tetrahedron Lett.|61|152143|doi:10.1016/j.tetlet.2020.152143
DOI: 10.35013/chyj-rj90
title: Patterns of Interracial Politics: Conflict and Cooperation in the City of Milwaukee, 1970
DOI: 10.35013/y92p-zw02
title: Milwaukee Study of Civil Disorder, 1967
DOI: 10.5517/ccdc.csd.cc23vcx8
title: CCDC 1961770: Experimental Crystal Structure Determination

description: Related Article: Justin T. Ernst, Peggy A. Thompson, Christian Nilewski, Paul A. Sprengeler, Samuel Sperry, Garrick Packard, Theodore Michels, Alan Xiang, Chinh Tran, Christopher J. Wegerski, Boreth Eam, Nathan P. Young, Sarah Fish, Joan Chen, Haleigh Howard, Jocelyn Staunton, Jolene Molter, Jeff Clarine, Andres Nevarez, Gary G. Chiang, Jim R. Appleman, Kevin R. Webster, Siegfried H. Reich|2020|J.Med.Chem.|63|5879|doi:10.1021/acs.jmedchem.0c00182
DOI: 10.5517/ccdc.csd.cc24sjr7
title: CCDC 1989789: Experimental Crystal Structure Determination

description: Related Article: Shabnam Pordel, Briana R Schrage, Christopher J. Ziegler, Jessica K. White|2020|Inorg.Chim.Acta|511|119845|doi:10.1016/j.ica.2020.119845
DOI: 10.35013/9xdx-yy36
title: Migrant Farm Workers in Wisconsin, 1978
DOI: 10.35013/ya6t-gz13
title: Milwaukee Parental Choice Program, 1990/1991-1994/1995
DOI: 10.7931/jwc3-zg41
title: Ford K.A. & Champion P.D. 2020: Alismataceae. In: Breitwieser, I.; Wilton, A.D. Flora of New Zealand - Seed Plants. Fascicle 7. Manaaki Whenua Press, Lincoln.
DOI: 10.35013/fwmx-j740
title: International News Exposure and National Images in a Third World Setting, 1982
DOI: 10.25500/edata.bham.00000497
title: Research data supporting "New traces of an old text: the corrections of Gregory-Aland 424 in Acts. Online appendix: corrections of 424 and collation"
DOI: 10.5517/ccdc.csd.cc24sjs8
title: CCDC 1989790: Experimental Crystal Structure Determination

description: Related Article: Shabnam Pordel, Briana R Schrage, Christopher J. Ziegler, Jessica K. White|2020|Inorg.Chim.Acta|511|119845|doi:10.1016/j.ica.2020.119845
DOI: 10.5517/ccdc.csd.cc25jzpd
title: CCDC 2012324: Experimental Crystal Structure Determination

description: Related Article: Svetlana Pakhomova, Pramuditha Abhayawardhana, Luigi G. Marzilli, Frank R. Fronczek|2020|CSD Communication|||
DOI: 10.35013/cfhd-m769
title: Search for Irish Immigrants Through the Boston Pilot, 1847 and 1848
DOI: 10.34740/kaggle/dsv/1277507
title: COVID-19 cases by Continent
DOI: 10.35013/ntx7-mj57
title: Man and the Variable Vulnerability of Island Life: A Study of Recent Vegetation Change in the Bahamas, 1972
title: Cat Island, Bahamas, Old Field Succession Study, 1972
DOI: 10.34740/kaggle/dsv/1277073
title: Covid-GAN and Covid-Net mini Chest X-ray
DOI: 10.35013/mnh3-m777
title: National Institute for Science Education Evaluation of The Why Files Site
DOI: 10.5517/ccdc.csd.cc25jrgy
title: CCDC 2012100: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Russell P. Hughes|2020|CSD Communication|||
DOI: 10.5517/ccdc.csd.cc201qc5
title: CCDC 1848696: Experimental Crystal Structure Determination

description: Related Article: Svetlana Pakhomova, Pramuditha Abhayawardhana, Luigi G. Marzilli, Frank R. Fronczek|2020|CSD Communication|||
DOI: 10.35083/hx08-h242
title: Host Factor Experiment (SCL005-R)

description: Purpose: To obtain samples for transcriptional and proteomic analysis using wild type and icSARS delta ORF6 virus in 2B-4 cells/sorted Calu-3 cells with high ACE2 expression. Details: Time Points = 0, 3, 7, 12, 24, 30, 36, 48, 54, 60 and 72h post infection; Done in triplicate for both RNA and protein; Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples; Inoculation medium for mock infection was the same as the medium used for virus infection. Infection done at an MOI of 5.
DOI: 10.35083/mjpg-m062
title: Host Factor Experiment (SCL005-P)

description: Purpose: To obtain samples for transcriptional and proteomic analysis using wild type and icSARS delta ORF6 virus in 2B-4 cells/sorted Calu-3 cells with high ACE2 expression. Details: Time Points = 0, 3, 7, 12, 24, 30, 36, 48, 54, 60 and 72h post infection; Done in triplicate for both RNA and protein; Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples; Inoculation medium for mock infection was the same as the medium used for virus infection. Infection done at an MOI of 5.
DOI: 10.35083/w27d-ah13
title: Host Factor Experiment (SCL006-P)

description: Purpose: To obtain samples for transcriptional analysis and proteomics in triplicate using wild typeicSARS urbani and icSARS Bat SRBD mutant in 2B4 cells/sorted Calu3 cells with high ACE2 expression. Overview of Experiment: Time Points = 0, 7, 12, 24, 30, 36, 48, 54, 60 and 72 hrs post infection. (Note: there is no time point at 7 h for icSARS Bat SRBD.) Done in triplicate for both RNA and Protein. Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates. Time matched mocks done in triplicate from same cell stock as rest of samples. Culture medium (the same as what the virus stock is in) was used for the mock infections. Infection was done at an MOI of 1.
DOI: 10.35083/0nse-xm32
title: Host Factor Experiment (SCL008-R)

description: Purpose: To obtain samples for transcriptional and proteomic analysis using wild type icSARS CoV and icSARS ExoNI and icSARS dNSP16 mutants in 2B-4 cells/sorted Calu-3 cells with high ACE2 expression. Details: Time Points = 0, 7, 12, 24, 36, 48, 60 and 72h post infection (Note: only 0, 24, 48 and 72hr samples analysed for proteomics); Done in triplicate for RNA and quadruplicate for protein; Replicates are defined as 3 or 4 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples; Inoculation medium for mock infection was the same as the medium used for virus infection. Infection done at an MOI of 5 for wild-type and dNSP16 mutant and an MOI 0f 1 for ExoNI mutant.
DOI: 10.35083/bebn-5d77
title: Host Factor Experiment (SCL006-R)

description: Purpose: To obtain samples for transcriptional analysis and proteomics in triplicate using wild typeicSARS urbani and icSARS Bat SRBD mutant in 2B4 cells/sorted Calu3 cells with high ACE2 expression. Overview of Experiment: Time Points = 0, 7, 12, 24, 30, 36, 48, 54, 60 and 72 hrs post infection. (Note: there is no time point at 7 h for icSARS Bat SRBD.) Done in triplicate for both RNA and Protein. Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates. Time matched mocks done in triplicate from same cell stock as rest of samples. Culture medium (the same as what the virus stock is in) was used for the mock infections. Infection was done at an MOI of 1.
DOI: 10.35083/nj24-tx75
title: Host Factor Experiment (SHAE003-R)

description: Purpose: To obtain samples from primary Human Airway Epitheilal (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants or A/CA/04/2009 (H1N1) influenza for transcriptional analysis. The time points are 0, 12, 24, 36, 48, 60, 72, 84 and 96h post-infection for SARS viruses (except SHAE003 which did not include the 12 and 36h timepoints), 0, 6, 12, 18, 24, 36 and 48h post-infection for H1N1 and 0, 6, 12, 18, 24, 36, 48, 60, 72, 84 and 96h for mocks. There are 2-4 replicate samples for all conditions; Replicates are defined as 2-4 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples. Inoculation medium for mock infection was the same as the medium used for virus infection. Infection done at an MOI of 2 for SARS and 1 or 2 for flu. SHAE005 is the combined data from SHAE002, 003 and 004 - 3 replicate experiments.
DOI: 10.35083/40re-t825
title: Host Factor Experiment (SCL008-P)

description: Purpose: To obtain samples for transcriptional and proteomic analysis using wild type icSARS CoV and icSARS ExoNI and icSARS dNSP16 mutants in 2B-4 cells/sorted Calu-3 cells with high ACE2 expression. Details: Time Points = 0, 7, 12, 24, 36, 48, 60 and 72h post infection (Note: only 0, 24, 48 and 72hr samples analysed for proteomics); Done in triplicate for RNA and quadruplicate for protein; Replicates are defined as 3 or 4 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples; Inoculation medium for mock infection was the same as the medium used for virus infection. Infection done at an MOI of 5 for wild-type and dNSP16 mutant and an MOI 0f 1 for ExoNI mutant.
DOI: 10.35083/fhrg-fq84
title: Host Factor Experiment (SHAE002-R)

description: Purpose: To obtain samples from primary Human Airway Epitheilal (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants or A/CA/04/2009 (H1N1) influenza for transcriptional analysis. The time points are 0, 12, 24, 36, 48, 60, 72, 84 and 96h post-infection for SARS viruses (except SHAE003 which did not include the 12 and 36h timepoints), 0, 6, 12, 18, 24, 36 and 48h post-infection for H1N1 and 0, 6, 12, 18, 24, 36, 48, 60, 72, 84 and 96h for mocks. There are 2-4 replicate samples for all conditions; Replicates are defined as 2-4 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples. Inoculation medium for mock infection was the same as the medium used for virus infection. Infection done at an MOI of 2 for SARS and 1 or 2 for flu. SHAE005 is the combined data from SHAE002, 003 and 004 - 3 replicate experiments.
DOI: 10.25810/c862-0e81.26
title: US Television Coverage of Climate Change or Global Warming, 2000-2020 - May 2020

description:         The Media and Climate Change Observatory Data monitors 120 sources (across newspapers, radio and TV) in 55 countries in seven different regions around the world. Data is assembled by accessing archives through the Lexis Nexis, Proquest and Factiva databases via the University of Colorado libraries. More information may be found at: http://mecco.colorado.edu.
DOI: 10.35094/sy5z-n506
title: Host Factor Experiment (IM006A-R)

description: Purpose: To obtain lung samples from C57BL6 mice infected with Vietnam/1203-CIP048_RG3/2004 (H5N1) for both transcriptional and proteomic analyses. Details: Time Points = 1, 2, 4 and 7 days post infection; 5 replicates for infected mice and triplicate mice for the mocks; Inoculation medium for mock infection was the same as the medium used for virus infection. Infection dose was 10^3 PFU.
DOI: 10.25810/4c3b-b819.26
title: World Newspaper Coverage of Climate Change or Global Warming, 2004-2020 - May 2020

description:         The Media and Climate Change Observatory Data monitors 120 sources (across newspapers, radio and TV) in 55 countries in seven different regions around the world. Data is assembled by accessing archives through the Lexis Nexis, Proquest and Factiva databases via the University of Colorado libraries. More information may be found at: http://mecco.colorado.edu.
DOI: 10.25810/k55w-7a04.26
title: World Radio Coverage of Climate Change or Global Warming, 2000-2020 - May 2020

description:         The Media and Climate Change Observatory Data monitors 120 sources (across newspapers, radio and TV) in 55 countries in seven different regions around the world. Data is assembled by accessing archives through the Lexis Nexis, Proquest and Factiva databases via the University of Colorado libraries. More information may be found at: http://mecco.colorado.edu.
DOI: 10.35094/r3d1-ze38
title: Host Factor Experiment (IM005-R)

description: Purpose: To obtain lung samples from C57BL6 mice infected with Vietnam/1203-CIP048_RG2/2004 (H5N1) for both transcriptional and proteomic analyses. Details: Time Points = 1, 2, 4 and 7 days post infection; 5 replicates/time point for infections; 3 mice/ time point for time matched mock infections. Infection dose was 10^4 PFU.
DOI: 10.34740/kaggle/dsv/1292490
title: COVID-19 cases by Continent
DOI: 10.35094/36e9-tw24
title: Host Factor Experiment (ICL004-R)

description: Purpose: To obtain samples from Calu-3 cells infected with A/Vietnam/1203/2004(H5N1) for both transcriptional and proteomics analyses. Details: Time Points = 0, 3, 7, 12, 18, and 24 h post infection; Done in triplicate for both RNA and Protein; Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples; Culture medium (the same as what the virus stock is in) was used for the mock infections. Infection done at an MOI of 1
DOI: 10.5517/ccdc.csd.cc25k597
title: CCDC 2012498: Experimental Crystal Structure Determination

description: Related Article: Alex L. Nguyen, M. Graca H. Vicente, Frank R. Fronczek|2020|CSD Communication|||
DOI: 10.35094/59vz-3867
title: Host Factor Experiment (IM005-P)

description: Purpose: To obtain lung samples from C57BL6 mice infected with Vietnam/1203-CIP048_RG2/2004 (H5N1) for both transcriptional and proteomic analyses. Details: Time Points = 1, 2, 4 and 7 days post infection; 5 replicates/time point for infections; 3 mice/ time point for time matched mock infections. Infection dose was 10^4 PFU.
DOI: 10.35094/fp3z-0n10
title: Host Factor Experiment (CA04M001-P)

description: Purpose: To look at the host response to different doses across 4 time points after infection. Samples were collected for both transcriptomics and proteomics. General Design: 20 week-old C57Bl6 mice; Three Doses = 1E3, 1E4, 1E5, 1E6 (PFU); Time points of 1, 2, 4 and 7 days; ~5 mice/time point for infections; 3 mice/timepoint for time matched mocks
DOI: 10.35094/mmxd-df62
title: Host Factor Experiment (E_R_MDM_H1N1)

description: Human monocyte-derived macrophages (MDM) serve as a model for resident alveolar macrophages (AM) in the human respiratory tract. MDM cells were analyzed at multiple time points in response to infection with influenza A/California/04/09 (H1N1), A/Wyoming/03/03 (H3N2), and A/Vietnam/1203/04 (H5N1) HALo virus. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.
DOI: 10.35094/drrk-fr39
title: Host Factor Experiment (ICL004-P)

description: Purpose: To obtain samples from Calu-3 cells infected with A/Vietnam/1203/2004(H5N1) for both transcriptional and proteomics analyses. Details: Time Points = 0, 3, 7, 12, 18, and 24 h post infection; Done in triplicate for both RNA and Protein; Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates; Time matched mocks done in triplicate from same cell stock as rest of samples; Culture medium (the same as what the virus stock is in) was used for the mock infections. Infection done at an MOI of 1