cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22219987
title: Supplementary Material for: Triglycerides and Renal Outcomes according to Albuminuria and in Consideration of other Metabolic Syndrome Components in Diabetic US Veterans

description: Objective: Hypertriglyceridemia, a component of the metabolic syndrome, is a known independent predictor of albuminuria and chronic kidney disease (CKD) in the general population. Previous studies have shown that the relationship of triglycerides with outcomes changes across stages of CKD. Our objective is to examine the association of triglycerides independent of other metabolic syndrome components with renal outcomes in diabetic patients with or without CKD. Research Design and Methods: This retrospective cohort study included diabetic US veteran patients with valid data on triglycerides (TG), estimated glomerular filtration rate (eGFR) and albuminuria (UACR), between fiscal years 2004 to 2006. Using Cox models adjusted for clinical characteristics and laboratory markers, we evaluated the relationship of TG with incident albuminuria (stratified by eGFR category) and based on eGFR (stratified by baseline albuminuria categories). To evaluate the relationship of TG with time to end-stage renal disease (ESRD), we stratified models by baseline CKD stage (eGFR category) and baseline albuminuria stage ascertained at time of TG measurement. Results: In a cohort of 138,675 diabetic veterans, the mean±SD age was 65±11 years old, and included 3% females and 14% African Americans. The cohort also included 28% of patients with non-dialysis dependent CKD (eGFR&lt;60 mL/min/173m2), as well as 28% of patients with albuminuria (≥30 mg/g). The median[IQR] of serum TG was 148[100, 222] mg/dL. We observed a slight positive linear association between TG and incident CKD after adjustment for case-mix and laboratory variables among non-albuminuric and microalbuminuric patients. High TG levels were associated with ESRD in CKD 3A non-albuminuric patients and in CKD 3A and 4/5 in patients with microalbuminuria. Conclusions: In a large cohort, we have shown that elevated TG are associated with all kidney outcomes tested independently of other metabolic syndrome components in diabetic patients with normal eGFR and normal albumin excretion rate, but the association is weaker in some groups of diabetic patients with pre-existing renal complications.
DOI: 10.6084/m9.figshare.22219987.v1
title: Supplementary Material for: Triglycerides and Renal Outcomes according to Albuminuria and in Consideration of other Metabolic Syndrome Components in Diabetic US Veterans

description: Objective: Hypertriglyceridemia, a component of the metabolic syndrome, is a known independent predictor of albuminuria and chronic kidney disease (CKD) in the general population. Previous studies have shown that the relationship of triglycerides with outcomes changes across stages of CKD. Our objective is to examine the association of triglycerides independent of other metabolic syndrome components with renal outcomes in diabetic patients with or without CKD. Research Design and Methods: This retrospective cohort study included diabetic US veteran patients with valid data on triglycerides (TG), estimated glomerular filtration rate (eGFR) and albuminuria (UACR), between fiscal years 2004 to 2006. Using Cox models adjusted for clinical characteristics and laboratory markers, we evaluated the relationship of TG with incident albuminuria (stratified by eGFR category) and based on eGFR (stratified by baseline albuminuria categories). To evaluate the relationship of TG with time to end-stage renal disease (ESRD), we stratified models by baseline CKD stage (eGFR category) and baseline albuminuria stage ascertained at time of TG measurement. Results: In a cohort of 138,675 diabetic veterans, the mean±SD age was 65±11 years old, and included 3% females and 14% African Americans. The cohort also included 28% of patients with non-dialysis dependent CKD (eGFR&lt;60 mL/min/173m2), as well as 28% of patients with albuminuria (≥30 mg/g). The median[IQR] of serum TG was 148[100, 222] mg/dL. We observed a slight positive linear association between TG and incident CKD after adjustment for case-mix and laboratory variables among non-albuminuric and microalbuminuric patients. High TG levels were associated with ESRD in CKD 3A non-albuminuric patients and in CKD 3A and 4/5 in patients with microalbuminuria. Conclusions: In a large cohort, we have shown that elevated TG are associated with all kidney outcomes tested independently of other metabolic syndrome components in diabetic patients with normal eGFR and normal albumin excretion rate, but the association is weaker in some groups of diabetic patients with pre-existing renal complications.
DOI: 10.34740/kaggle/dsv/5115250
title: Dataset, Images of symbols
DOI: 10.5281/zenodo.7586294
title: D-MULTI-P2

description: D-MULTI Part 2
DOI: 10.5281/zenodo.7586293
title: D-MULTI-P2

description: D-MULTI Part 2
DOI: 10.5281/zenodo.7701425
title: D-MULTI-P2

description: D-MULTI Part 2
DOI: 10.5519/qd.negakdz0
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (563 records)
DOI: 10.6084/m9.figshare.21953048.v1
title: Supplementary Material for: Twenty-four weeks of L-carnitine combined with leucine supplementation does not increase the muscle carnitine content in healthy active subjects

description: Introduction: To increase the total carnitine (TC) content in muscles, LC should be co-ingested with carbohydrates to induce an insulin response. Leucine has an insulin secretagogue effect. Therefore, the primary aim of this study was to examine the effects of 24 weeks of LC and leucine supplementation on the skeletal muscle TC content, muscle mass, and strength in active college-aged subjects. The secondary aim was to determine the activation of the Akt/mTOR signaling pathway in skeletal muscles after supplementation. Methods: Over the 24 weeks, the participants were supplemented with either 1 g of L-carnitine-L-tartrate and 3 g of leucine per day (LC + L group; n = 7) or 4 g of leucine per day (L group; n = 7) as a placebo. Before and 24 weeks after the initiation of the study protocol, the free carnitine (FC) and TC content in plasma and muscle samples, as well as body composition and muscle strength were measured. In addition, the phosphorylation of the Akt/mTOR pathway proteins in muscles was evaluated. Results: Plasma FC and TC content increased in LC + L group after 24 weeks of supplementation (p = 0.003 and 0.010, respectively). However, the skeletal muscle FC and TC content were not affected by the supplementation protocol. No changes were noted in the body mass and composition; serum insulin-like growth factor-1 concentration; and phosphorylation of the signaling pathway proteins Akt, mTOR and p70S6K. Conclusion: LC supplementation may have the potential to exert beneficial effects in muscle atrophy. Therefore, additional research is necessary to investigate the effect of various LC supplementation protocols.
DOI: 10.5281/zenodo.7701642
title: PsySuite: Performing multimodal psychophysical testing within the Android environment

description: Data used for either the hardware or the behavioral validation of the Android APP <em>PsySuite</em>.
DOI: 10.25345/c5zg6gh57
title: MassIVE MSV000091413 - Rab35 knockdown in primary mouse hepatoblasts
title: To study the role of Rab35 in the formation of bile canaliculi, primary mouse hepatoblasts were acquired, cultured in matrigel, and subjected to Rab35 knockdown by siRNA with scrambled control (4 biol. replicates each, block-randomised). Samples were subjected to S-trap protein digest and label-free quantification by staggered DIA demultiplexed with MSConvert and processed with DIA-NN, followed by differential expression and gene set enrichment analysis.
DOI: 10.34740/kaggle/dsv/5115354
title: 2021 World Population (updated daily)
DOI: 10.6084/m9.figshare.21441396
title: Plectropomus leopardus genome

description: <em>Plectropomus leopardus</em>, as known as leopard coral grouper, is a valuable marine fish that has gradually been bred artificially. To promote future conservation, molecular breeding, and comparative studies, we generated an improved high-quality chromosomal-level genome assembly of leopard coral grouper using Nanopore long-reads, Illumina short reads, and the Hi-C sequencing data. The draft genome is 849.74Mb with 45 contigs and N50 of 35.59 Mb. Finally, a total of 846.49 Mb corresponding to 99.6% of the contig sequences was anchored to 24 pseudo-chromosomes using Hi-C technology. A final set of 25,965 genes is annotated after manual curation of the predicted gene models, and BUSCO analysis yielded a completeness score of 99.5%. This study significantly improves the utility of the grouper genome and provided a reference for the study of molecular breeding, genomics and biology in this species.
DOI: 10.6084/m9.figshare.21441396.v2
title: Plectropomus leopardus genome

description: <em>Plectropomus leopardus</em>, as known as leopard coral grouper, is a valuable marine fish that has been gradually artificial breeding. To promote future conservation, molecular breeding and comparative studies, we generated an improved high-quality chromosomal-level genome assembly of leopard coral grouper using Nanopore long-reads, BGI short reads, and the Hi-C sequencing data, as well as protein-coding genes predicted <em>de novo</em> and verified using sufficient transcriptome data. The draft genome of 849.74Mb with 45 contigs and N50 of 35.59 Mb. Finally, a total of 846.49 Mb (99.6%) of based were anchored to 24 pseudo-chromosomes using Hi-C technology. A final set of 27,285 genes is annotated after manual curation of the predicted gene models, and BUSCO analysis yielded a completeness score of 99.5%. This study significantly improves the utility of the grouper genome and is a reference for the study of molecular breeding and fish genomics and biology.
DOI: 10.6084/m9.figshare.20764861
title: How Well Static Type Checkers Work with Gradual Typing? A Case Study on Python

description: This is the dataset for the paper, which is accepted at ICPC2023.
DOI: 10.6084/m9.figshare.20764861.v1
title: How Well Static Type Checkers Work with Gradual Typing? A Case Study on Python

description: This is the dataset for the paper, which is accepted at ICPC2023.
DOI: 10.23729/1df0f5bd-f952-4fbf-9be4-3da9f1e65563
title: Pekka Halonen Paint Tubes preview

description: Pekka Halonen's paint tubes acquired from the Halosenniemi museum and imaged to look at their internal structure. Results were included in Butcher, A.R., Lukkari, S., 2022. Pekka Halonen and his paints. Hidden secrets revealed using a geomaterials approach. Geologi 74 (2), 91-94. Preview of PAS-dataset https://doi.org/10.23729/001b612c-3f22-4213-bc0a-915907dc2f8b
DOI: 10.6084/m9.figshare.22220011
title: Clothing8

description: clothing classfication
DOI: 10.6084/m9.figshare.22183619
title: Estimating the Cost of Thalassemia Care across the World: A Thalassemia International Federation Model

description: Estimating the cost of thalassemia care is important for the optimization of care planning, resource allocation and the empowerment of patient advocacy. However, available evidence is heterogeneous, reflecting diverse healthcare systems and cost estimation methods. We sought to build a globally applicable cost model for thalassemia care. We followed a three-step approach, including (i) a targeted literature review to identify previous cost-of-illness studies on thalassemia; (ii) a generic model development based on the main determinants of cost in different countries emerged from a literature review and validated by a team of medical experts; (iii) a piloting of the model using data from two diverse countries. The literature review revealed studies focusing on the total costs of thalassemia care or the cost or cost-effectiveness of specific treatment or prevention modalities in high- and low-prevalence countries across the world. The resulting evidence was used to build a model that calculates total annual therapy cost based on entry of country-level and patient-level data, and data on healthcare modalities, indirect costs and prevention. Testing the model using published data from the UK, Iran, India and Malaysia, revealed an annual cost per patient of £81,796.00 for the UK, Iranian rial (IRR) 13,757.00 for Iran, Indian rupee (INR) 166,750.00 for India and Malyasian ringgit (or dollar) (MYR) 111,372.00 for Malaysia. A globally applicable model that calculates total annual cost of thalassemia care was built based on existing evidence. The model successfully predicted the annual cost of thalassemia care in the UK, Iran, India and Malaysia.
DOI: 10.6084/m9.figshare.22183619.v1
title: Estimating the Cost of Thalassemia Care across the World: A Thalassemia International Federation Model

description: Estimating the cost of thalassemia care is important for the optimization of care planning, resource allocation and the empowerment of patient advocacy. However, available evidence is heterogeneous, reflecting diverse healthcare systems and cost estimation methods. We sought to build a globally applicable cost model for thalassemia care. We followed a three-step approach, including (i) a targeted literature review to identify previous cost-of-illness studies on thalassemia; (ii) a generic model development based on the main determinants of cost in different countries emerged from a literature review and validated by a team of medical experts; (iii) a piloting of the model using data from two diverse countries. The literature review revealed studies focusing on the total costs of thalassemia care or the cost or cost-effectiveness of specific treatment or prevention modalities in high- and low-prevalence countries across the world. The resulting evidence was used to build a model that calculates total annual therapy cost based on entry of country-level and patient-level data, and data on healthcare modalities, indirect costs and prevention. Testing the model using published data from the UK, Iran, India and Malaysia, revealed an annual cost per patient of £81,796.00 for the UK, Iranian rial (IRR) 13,757.00 for Iran, Indian rupee (INR) 166,750.00 for India and Malyasian ringgit (or dollar) (MYR) 111,372.00 for Malaysia. A globally applicable model that calculates total annual cost of thalassemia care was built based on existing evidence. The model successfully predicted the annual cost of thalassemia care in the UK, Iran, India and Malaysia.
DOI: 10.6084/m9.figshare.22220071
title: Supplementary Material for: Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy on 1.5T T2*-Weighted Imaging

description: <b><i>Background:</i></b> Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary and sporadic cerebral amyloid angiopathy (CAA) on 3T MRI using primarily susceptibility-weighted imaging. <b><i>Objectives:</i></b> Our aim was to assess cerebellar SS in sporadic CAA patients using 1.5T T2*-weighted MRI and to evaluate possible underlying mechanisms. <b><i>Method:</i></b> We retrospectively screened MRI scans of sporadic probable CAA patients initially presenting with intracerebral hemorrhage-, acute subarachnoid hemorrhage- or cortical SS-related symptoms between September 2009 and January 2022 registered in our stroke database. Patients with familial CAA were excluded. On 1.5T T2*-weighted MRI, cerebellar SS (including kappa statistics for interobserver agreement) was assessed together with typical CAA hemorrhagic features and with the presence of supratentorial macrobleed and cortical SS adjacent to the tentorium cerebelli (TC) and TC hemosiderosis. <b><i>Results:</i></b> We screened 151 patients and finally included 111 CAA patients (median age 77) with cerebellar SS observed in 6 (5%) patients. Cerebellar SS presence was associated with a higher number of supratentorial macrobleeds (median <i>n</i> = 3 vs. <i>n</i> = 1, <i>p</i> = 0.0012), presence of supratentorial macrobleed adjacent to the TC (<i>p</i> = 0.002), and TC hemosiderosis (<i>p</i> = 0.005). <b><i>Conclusions:</i></b> Cerebellar SS in CAA patients can be identified on 1.5T T2*-weighted imaging. Associated MRI characteristics suggest contamination from supratentorial macrobleeds.
DOI: 10.6084/m9.figshare.22220071.v1
title: Supplementary Material for: Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy on 1.5T T2*-Weighted Imaging

description: <b><i>Background:</i></b> Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary and sporadic cerebral amyloid angiopathy (CAA) on 3T MRI using primarily susceptibility-weighted imaging. <b><i>Objectives:</i></b> Our aim was to assess cerebellar SS in sporadic CAA patients using 1.5T T2*-weighted MRI and to evaluate possible underlying mechanisms. <b><i>Method:</i></b> We retrospectively screened MRI scans of sporadic probable CAA patients initially presenting with intracerebral hemorrhage-, acute subarachnoid hemorrhage- or cortical SS-related symptoms between September 2009 and January 2022 registered in our stroke database. Patients with familial CAA were excluded. On 1.5T T2*-weighted MRI, cerebellar SS (including kappa statistics for interobserver agreement) was assessed together with typical CAA hemorrhagic features and with the presence of supratentorial macrobleed and cortical SS adjacent to the tentorium cerebelli (TC) and TC hemosiderosis. <b><i>Results:</i></b> We screened 151 patients and finally included 111 CAA patients (median age 77) with cerebellar SS observed in 6 (5%) patients. Cerebellar SS presence was associated with a higher number of supratentorial macrobleeds (median <i>n</i> = 3 vs. <i>n</i> = 1, <i>p</i> = 0.0012), presence of supratentorial macrobleed adjacent to the TC (<i>p</i> = 0.002), and TC hemosiderosis (<i>p</i> = 0.005). <b><i>Conclusions:</i></b> Cerebellar SS in CAA patients can be identified on 1.5T T2*-weighted imaging. Associated MRI characteristics suggest contamination from supratentorial macrobleeds.
DOI: 10.6084/m9.figshare.22220065
title: Data points for Figs. & Tables NIR & Cancer 2023 Obrador et al..xlsx

description: At present, the applications and efficacy of non-ionizing radiations (NIR) in oncotherapy are limited. In terms of potential combinations, the use of biocompatible magnetic nanoparticles as heat mediators has been extensively investigated. Nevertheless, the development of more efficient heat nanomediators that may exhibit high specific absorption rates still is an unsolved problem. Our aim was to investigate if externally applied magnetic fields and a heat-inducing NIR affect tumor cell viability. To this end, under <em>in vitro</em> conditions, different human cancer cells (A2058 melanoma, AsPC1 pancreas carcinoma, MDA-MB-231 breast carcinoma) were treated with the combination of electromagnetic fields (EMFs, using solenoids) and hyperthermia (HT, using a thermostated bath). The effect of NIR was also studied in combination with standard chemotherapy and targeted therapy. An experimental device combining EMFs and high intensity focused ultrasounds (HIFU)-induced HT was tested <em>in vivo</em>. EMFs (25 mT, 4h) or HT (52ºC, 40 min) showed a limited effect on cancer cell viability <em>in vitro</em>. However, their combination decreased viability to approx. 16%, 50%, and 21% of controls values in A2058, AsPC1, and MDA-MB-231 cells, respectively. Increased lysosomal permeability, release of cathepsins into the cytosol and mitochondria-dependent activation of cell death are the underlying mechanisms. Cancer cells could be completely eliminated combining EMFs, HT and standard chemotherapy or EMFs, HT and anti-Hsp70-targeted therapy. As a proof of concept, <em>in vivo</em> experiments performed in AsPC1 xenografts showed that combination of EMFs, HIFU-induced HT, standard chemotherapy and a lysosomal permeabilizer induces a complete cancer regression.
DOI: 10.6084/m9.figshare.22220065.v1
title: Data points for Figs. & Tables NIR & Cancer 2023 Obrador et al..xlsx

description: At present, the applications and efficacy of non-ionizing radiations (NIR) in oncotherapy are limited. In terms of potential combinations, the use of biocompatible magnetic nanoparticles as heat mediators has been extensively investigated. Nevertheless, the development of more efficient heat nanomediators that may exhibit high specific absorption rates still is an unsolved problem. Our aim was to investigate if externally applied magnetic fields and a heat-inducing NIR affect tumor cell viability. To this end, under <em>in vitro</em> conditions, different human cancer cells (A2058 melanoma, AsPC1 pancreas carcinoma, MDA-MB-231 breast carcinoma) were treated with the combination of electromagnetic fields (EMFs, using solenoids) and hyperthermia (HT, using a thermostated bath). The effect of NIR was also studied in combination with standard chemotherapy and targeted therapy. An experimental device combining EMFs and high intensity focused ultrasounds (HIFU)-induced HT was tested <em>in vivo</em>. EMFs (25 mT, 4h) or HT (52ºC, 40 min) showed a limited effect on cancer cell viability <em>in vitro</em>. However, their combination decreased viability to approx. 16%, 50%, and 21% of controls values in A2058, AsPC1, and MDA-MB-231 cells, respectively. Increased lysosomal permeability, release of cathepsins into the cytosol and mitochondria-dependent activation of cell death are the underlying mechanisms. Cancer cells could be completely eliminated combining EMFs, HT and standard chemotherapy or EMFs, HT and anti-Hsp70-targeted therapy. As a proof of concept, <em>in vivo</em> experiments performed in AsPC1 xenografts showed that combination of EMFs, HIFU-induced HT, standard chemotherapy and a lysosomal permeabilizer induces a complete cancer regression.
DOI: 10.5281/zenodo.7616219
title: PAN23 Profiling Cryptocurrency Influencers with Few-shot Learning

description: This is the dataset for the shared task on Profiling Cryptocurrency Influencers with Few-shot Learning. Please consult the task's page for further details on the format, the dataset's creation, and links to baselines and utility code. <strong>Task</strong>: In this shared task we aim to profile cryptocurrency influencers in social media, from a low-resource perspective. Moreover, we propose to categorize other related aspects of the influencers, also using a low-resource setting. Specifically, we focus on English Twitter posts for three different sub-tasks: <strong>Low-resource influencer profiling (subtask1):</strong> Input:<br> 32 users per label with a maximum of 10 English tweets each.<br> Classes: (1) null, (2) nano, (3) micro, (4) macro, (5) mega Official evaluation metric: Macro F1 Submission: TIRA. Baselines: User-character Logistic Regression; t5-large (bi-encoders) - zero shot [7], t5-large (label tuning) - few shot [7] <strong>Low-resource influencer interest identification (subtask2):</strong> Input:<br> 64 users per label with 1 English tweet each.<br> Classes: (1) technical information, (2) price update, (3) trading matters, (4) gaming, (5) other Official evaluation metric: Macro F1 Submission: TIRA. Baselines: User-character Logistic Regression; t5-large (bi-encoders) - zero shot [7], t5-large (label tuning) - few shot [7] <strong>Low-resource influencer intent identification (subtask3):</strong> Input:<br> 64 users per label with 1 English tweets each.<br> Classes: (1) subjective opinion, (2) financial information, (3) advertising, (4) announcement Official evaluation metric: Macro F1 Submission: TIRA. Baselines: User-character Logistic Regression; t5-large (bi-encoders) - zero shot [7], t5-large (label tuning) - few shot [7]