cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30553033.v1
title: Determinants of non-compliance with additional booster doses of the SARS-CoV-2 vaccine in people living with HIV (PWH): An observational study based on a behavioral and epidemiological survey in Rome (Italy)

description: Rejection of new anti-SARS-CoV-2 booster doses among immunosuppressed and elderly individuals may be a concern, especially as the intention to vaccinate does not always translate into actual behavior. Few studies have addressed this issue in people living with HIV (PWH). We investigated attitudes of PWH toward SARS-CoV-2 vaccination, focusing on factors associated with noncompliance with additional vaccine doses (AVDs, 4th and 5th). We analyzed participants of the prospective observational HIV-VAC study conducted at the National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome (September 2022–June 2023). Eligible patients with complete vaccination schedules were voluntarily recruited and completed a 13-item survey on demographics and vaccination attitudes. Multivariate logistic regression was used to describe the relationship between “compliant” vs. “non-compliant” groups. Of 316 participants, 240 (75.9%) were compliant and 76 (24.1%) non-compliant. Compliance was 70% for the fourth and 30% for the fifth dose; noncompliance was 19.9% and 4.1%, respectively. Older age (<i>p</i> = .012) and information from non-institutional sources (<i>p </i>&lt; .0001) were associated with higher noncompliance. Among non-compliant participants, 34.4% reported concerns about side effects. In PWH aged &gt;50, fear of side effects and reliance on unofficial information sources are major barriers to AVD uptake. Non-compliant individuals tend to persist in their refusal over time. Tailored communication and healthcare professional training are crucial to improve vaccine adherence, and further multicenter studies are warranted.
DOI: 10.6084/m9.figshare.28473615
title: Global research trends of immunosenescence and immunotherapy: A bibliometric study

description: Immunosenescence refers to the gradual decline in immune system function with age, increasing susceptibility to infections and cancer in the elderly. The advent of novel immunotherapies has revolutionized the field of cancer treatment. However, the majority of patients exhibit poor re-sponses to immunotherapy, with immunosenescence likely playing a significant role. In recent years, significant progress has been made in understanding the interplay between immunosenescence and immunotherapy. Our research aims to explore the prospects and development trends in the field of immunosenescence and immunotherapy using a bibliometric analysis. Relevant articles were collected from the Web of Science Core Collection (WoSCC) (retrieved on July 20, 2024). Primary bibliometric characteristics were analyzed using the R package “Biblio-metrix,” and keyword co-occurrence analysis and visualization were conducted using VOSviewer. A total of 213 English-language original research and review articles spanning 35 years were re-trieved for bibliometric analysis. There was a surge in publications in this field starting in 2017. The United States and China contributed the most articles. Frontiers in Immunology was the most productive journal, while the University of California System was the highest contributing institution. Besse Benjamin from France emerged as the most influential researcher in this field. Popular keywords included “nivolumab,” “T cells,” “dendritic cells,” and “regulatory T cells.” The “immunosenescence-associated secretory phenotype” has become a new hotspot, with immune checkpoint inhibitors remaining a central theme in this domain. The field of immunosenescence and immunotherapy is entering a phase of rapid development and will continue to hold significant value in future research.
DOI: 10.6084/m9.figshare.28473615.v1
title: Global research trends of immunosenescence and immunotherapy: A bibliometric study

description: Immunosenescence refers to the gradual decline in immune system function with age, increasing susceptibility to infections and cancer in the elderly. The advent of novel immunotherapies has revolutionized the field of cancer treatment. However, the majority of patients exhibit poor re-sponses to immunotherapy, with immunosenescence likely playing a significant role. In recent years, significant progress has been made in understanding the interplay between immunosenescence and immunotherapy. Our research aims to explore the prospects and development trends in the field of immunosenescence and immunotherapy using a bibliometric analysis. Relevant articles were collected from the Web of Science Core Collection (WoSCC) (retrieved on July 20, 2024). Primary bibliometric characteristics were analyzed using the R package “Biblio-metrix,” and keyword co-occurrence analysis and visualization were conducted using VOSviewer. A total of 213 English-language original research and review articles spanning 35 years were re-trieved for bibliometric analysis. There was a surge in publications in this field starting in 2017. The United States and China contributed the most articles. Frontiers in Immunology was the most productive journal, while the University of California System was the highest contributing institution. Besse Benjamin from France emerged as the most influential researcher in this field. Popular keywords included “nivolumab,” “T cells,” “dendritic cells,” and “regulatory T cells.” The “immunosenescence-associated secretory phenotype” has become a new hotspot, with immune checkpoint inhibitors remaining a central theme in this domain. The field of immunosenescence and immunotherapy is entering a phase of rapid development and will continue to hold significant value in future research.
DOI: 10.6084/m9.figshare.30366315
title: Effectiveness and impact of 7 and 13-valent pneumococcal conjugate vaccines in Chinese children: A systematic review and meta-analysis

description: Pneumococcal conjugate vaccines (PCVs) are highly effective against pneumococcal diseases, yet coverage in China remains low. We conducted a systematic review of observational studies published between 2006 and 2024 in mainland China, Hong Kong, and Taiwan to evaluate the effectiveness and impact of PCV7 and PCV13. Twenty-seven studies were identified, of which 17 were included in meta-analyses. PCVs showed strong protection against invasive pneumococcal disease (pooled effectiveness: 88.8%, 95%CI: 80.7–96.8%) and significantly reduced the incidence of community-acquired pneumonia (14.3%, 95%CI: 10.1–18.5%). Vaccine-serotype CAP was reduced by 69.9% (95%CI: 60.0–79.7%), and moderate benefits were observed against severe pneumonia, mortality, and recurrent episodes. Evidence for otitis media remained limited. These findings highlight the substantial health benefits of PCVs in Chinese children and underscore the importance of expanding vaccine utilization to reduce the burden of pneumococcal disease.
DOI: 10.6084/m9.figshare.30366315.v1
title: Effectiveness and impact of 7 and 13-valent pneumococcal conjugate vaccines in Chinese children: A systematic review and meta-analysis

description: Pneumococcal conjugate vaccines (PCVs) are highly effective against pneumococcal diseases, yet coverage in China remains low. We conducted a systematic review of observational studies published between 2006 and 2024 in mainland China, Hong Kong, and Taiwan to evaluate the effectiveness and impact of PCV7 and PCV13. Twenty-seven studies were identified, of which 17 were included in meta-analyses. PCVs showed strong protection against invasive pneumococcal disease (pooled effectiveness: 88.8%, 95%CI: 80.7–96.8%) and significantly reduced the incidence of community-acquired pneumonia (14.3%, 95%CI: 10.1–18.5%). Vaccine-serotype CAP was reduced by 69.9% (95%CI: 60.0–79.7%), and moderate benefits were observed against severe pneumonia, mortality, and recurrent episodes. Evidence for otitis media remained limited. These findings highlight the substantial health benefits of PCVs in Chinese children and underscore the importance of expanding vaccine utilization to reduce the burden of pneumococcal disease.
DOI: 10.6084/m9.figshare.29150145
title: How has the field of immunogenic cell death in breast cancer evolved and impacted clinical practice over the past eleven years?

description: This study elucidates the research landscape of immunogenic cell death (ICD) in breast cancer through a bibliometric analysis of 457 Web of Science articles. Contributions from China and the USA are particularly prominent, with notable international collaborations. Core journals such as <i>Biomaterials</i> published influential studies, while researchers like Huang Y made impactful contributions. High-frequency keyword analysis identified key research hotspots, including immunotherapy, the tumor microenvironment, and nanomedicine. The integration of chemotherapy with immunotherapy and the identification of key proteins have driven recent advancements. Fundamental research on immunotherapy, photodynamic therapy (PDT), and triple-negative breast cancer (TNBC) points to future trends and potential breakthroughs. This study offers a strategic overview of ICD in breast cancer, providing insights into clinical practice and guiding future research in the field.
DOI: 10.6084/m9.figshare.29150145.v1
title: How has the field of immunogenic cell death in breast cancer evolved and impacted clinical practice over the past eleven years?

description: This study elucidates the research landscape of immunogenic cell death (ICD) in breast cancer through a bibliometric analysis of 457 Web of Science articles. Contributions from China and the USA are particularly prominent, with notable international collaborations. Core journals such as <i>Biomaterials</i> published influential studies, while researchers like Huang Y made impactful contributions. High-frequency keyword analysis identified key research hotspots, including immunotherapy, the tumor microenvironment, and nanomedicine. The integration of chemotherapy with immunotherapy and the identification of key proteins have driven recent advancements. Fundamental research on immunotherapy, photodynamic therapy (PDT), and triple-negative breast cancer (TNBC) points to future trends and potential breakthroughs. This study offers a strategic overview of ICD in breast cancer, providing insights into clinical practice and guiding future research in the field.
DOI: 10.6084/m9.figshare.30382974
title: Maternal influenza vaccination intention and associated factors among pregnant women in Guizhou Province, China

description: Despite global recommendations, maternal influenza vaccination coverage in China remains critically low. This hospital-based cross-sectional study (January–February 2022) applied the Health Belief Model (HBM) to examine determinants among 564 pregnant women in Guizhou Province. Mann-Whitney U tests and modified Poisson regression were employed to compare inter-group distributions and estimate prevalence ratios (PRs). Analysis revealed only 11.9% (67 of 564) of respondents received pre-pregnancy vaccination, and 36.7% (207 of 564) intended to be vaccinated during pregnancy. Key HBM-based predictors of vaccination intention included: (i) perceived barriers, primarily fetal/maternal safety concerns and familial opposition; (ii) cues to action and perceived benefits; and (iii) perceived susceptibility and severity. PRs and 95% CIs across quantiles indicated statistical significance in influenza vaccination intention by levels of perceived barriers (contrast = –0.34; 95% CI: −0.51, −0.17; <i>P</i><sub><i>trend</i></sub> &lt; 0.001), cues to action, and perceived benefits (contrast = 0.34; 95% CI: 0.13, 0.55; <i>P</i><sub><i>trend</i></sub> = 0.002). These context-specific determinants provide the basis for our intervention strategies and measures. Integrated interventions, such as prenatal counseling, mobile health education, financial incentives, peer networks, and reminders, may enhance maternal influenza vaccination coverage, warranting broader implementation.
DOI: 10.6084/m9.figshare.30382974.v1
title: Maternal influenza vaccination intention and associated factors among pregnant women in Guizhou Province, China

description: Despite global recommendations, maternal influenza vaccination coverage in China remains critically low. This hospital-based cross-sectional study (January–February 2022) applied the Health Belief Model (HBM) to examine determinants among 564 pregnant women in Guizhou Province. Mann-Whitney U tests and modified Poisson regression were employed to compare inter-group distributions and estimate prevalence ratios (PRs). Analysis revealed only 11.9% (67 of 564) of respondents received pre-pregnancy vaccination, and 36.7% (207 of 564) intended to be vaccinated during pregnancy. Key HBM-based predictors of vaccination intention included: (i) perceived barriers, primarily fetal/maternal safety concerns and familial opposition; (ii) cues to action and perceived benefits; and (iii) perceived susceptibility and severity. PRs and 95% CIs across quantiles indicated statistical significance in influenza vaccination intention by levels of perceived barriers (contrast = –0.34; 95% CI: −0.51, −0.17; <i>P</i><sub><i>trend</i></sub> &lt; 0.001), cues to action, and perceived benefits (contrast = 0.34; 95% CI: 0.13, 0.55; <i>P</i><sub><i>trend</i></sub> = 0.002). These context-specific determinants provide the basis for our intervention strategies and measures. Integrated interventions, such as prenatal counseling, mobile health education, financial incentives, peer networks, and reminders, may enhance maternal influenza vaccination coverage, warranting broader implementation.
DOI: 10.6084/m9.figshare.28348361
title: Research trends of neoadjuvant therapy for breast cancer: A bibliometric analysis

description: The approach of neoadjuvant therapy for breast cancer, which involves administering systemic treatment prior to primary surgery, has undergone substantial advancements in recent decades. This strategy is intended to reduce tumor size, thereby enabling less invasive surgical procedures and enhancing patient outcomes. This study presents a comprehensive bibliometric analysis of research trends in neoadjuvant therapy for breast cancer from 2009 to 2024. Using data extracted from the Web of Science Core Collection, a total of 3,674 articles were analyzed to map the research landscape in this field. The analysis reveals a steady increase in publication output, peaking in 2022, with the United States and China identified as the leading contributors. Key institutions, such as the University of Texas System and MD Anderson Cancer Center, have been instrumental in advancing the research on neoadjuvant therapy. The study also highlights the contributions of influential authors like Sibylle Loibl and Gunter von Minckwitz, as well as major journals such as the Journal of Clinical Oncology. Emerging research topics, including immunotherapy, liquid biopsy, and artificial intelligence, are gaining prominence and represent potential future directions for clinical applications. This bibliometric analysis provides critical insights into global research trends, key contributors, and future developments in the field of neoadjuvant therapy for breast cancer, offering a foundation for future research and clinical practice advancements.
DOI: 10.6084/m9.figshare.28348361.v1
title: Research trends of neoadjuvant therapy for breast cancer: A bibliometric analysis

description: The approach of neoadjuvant therapy for breast cancer, which involves administering systemic treatment prior to primary surgery, has undergone substantial advancements in recent decades. This strategy is intended to reduce tumor size, thereby enabling less invasive surgical procedures and enhancing patient outcomes. This study presents a comprehensive bibliometric analysis of research trends in neoadjuvant therapy for breast cancer from 2009 to 2024. Using data extracted from the Web of Science Core Collection, a total of 3,674 articles were analyzed to map the research landscape in this field. The analysis reveals a steady increase in publication output, peaking in 2022, with the United States and China identified as the leading contributors. Key institutions, such as the University of Texas System and MD Anderson Cancer Center, have been instrumental in advancing the research on neoadjuvant therapy. The study also highlights the contributions of influential authors like Sibylle Loibl and Gunter von Minckwitz, as well as major journals such as the Journal of Clinical Oncology. Emerging research topics, including immunotherapy, liquid biopsy, and artificial intelligence, are gaining prominence and represent potential future directions for clinical applications. This bibliometric analysis provides critical insights into global research trends, key contributors, and future developments in the field of neoadjuvant therapy for breast cancer, offering a foundation for future research and clinical practice advancements.
DOI: 10.6084/m9.figshare.28269325
title: Unreliable information and fear: Barriers to vaccination among IBD patients in China

description: Vaccination plays a crucial role in safeguarding individuals with inflammatory bowel disease (IBD) from potential epidemics. In light of the resurgence of COVID-19 in China, unvaccinated IBD patients are vulnerable to infection and potentially serious complications. The aim of this study is to assess the vaccination uptake and willingness among IBD patients, as well as to explore the factors influencing their decision to decline vaccination. An online questionnaire was distributed and analyzed. Bivariate analyses and logistic regression models were used to identify relevant factors. Two hundred and three patients from 243 non-vaccinated respondents were included in the analysis. A total of 167 (82.3%) respondents continued to decline vaccination, with individuals holding stable employment and higher family income displaying significantly lower intent (<i>p</i> &lt; .05). The primary factors contributing to their hesitancy were misinformation and apprehension regarding potential side effects. Obtaining vaccine information from online sources, particularly text-based content, and apprehensions surrounding the adverse effects of COVID-19 vaccination were also found to significantly diminish willingness to receive the vaccine (<i>p</i> &lt; .01). The present study revealed that unreliable information about vaccines is a key factor of hesitancy among non-vaccinated IBD patients. Making efforts to spread true information about the COVID-19 vaccine is of great importance.
DOI: 10.6084/m9.figshare.28269325.v1
title: Unreliable information and fear: Barriers to vaccination among IBD patients in China

description: Vaccination plays a crucial role in safeguarding individuals with inflammatory bowel disease (IBD) from potential epidemics. In light of the resurgence of COVID-19 in China, unvaccinated IBD patients are vulnerable to infection and potentially serious complications. The aim of this study is to assess the vaccination uptake and willingness among IBD patients, as well as to explore the factors influencing their decision to decline vaccination. An online questionnaire was distributed and analyzed. Bivariate analyses and logistic regression models were used to identify relevant factors. Two hundred and three patients from 243 non-vaccinated respondents were included in the analysis. A total of 167 (82.3%) respondents continued to decline vaccination, with individuals holding stable employment and higher family income displaying significantly lower intent (<i>p</i> &lt; .05). The primary factors contributing to their hesitancy were misinformation and apprehension regarding potential side effects. Obtaining vaccine information from online sources, particularly text-based content, and apprehensions surrounding the adverse effects of COVID-19 vaccination were also found to significantly diminish willingness to receive the vaccine (<i>p</i> &lt; .01). The present study revealed that unreliable information about vaccines is a key factor of hesitancy among non-vaccinated IBD patients. Making efforts to spread true information about the COVID-19 vaccine is of great importance.
DOI: 10.6084/m9.figshare.28551593
title: Attitudes and acceptance of vaccination against neglected tropical diseases: A multi-country study in Asia

description: This study aims to explore the willingness of individuals to be vaccinated against NTDs in Asian countries and China. Between June and December 2023, an anonymous cross-sectional survey was carried out in five Asian countries alongside China. Overall, 48.4% indicated being somewhat willing and 29.2% expressing extreme willingness to receive NTDs vaccination. High attitude scores (adjusted odds ratio [aOR] = 1.54, 95% confidence interval (CI): 11.35–1.75) was associated with higher willingness to be vaccinated against NTDs. The odds of accepting the NTDs vaccine increased among individuals without occupational exposure to NTDs (aOR = 1.46, 95% CI: 1.27–1.68). Those residing in very clean environments exhibited heightened odds of willingness (aOR = 2.94, 95% CI: 2.10–4.11), whereas individuals in somewhat dirty environments demonstrated reduced odds of willingness (aOR = 0.74, 95% CI: 0.56–0.98) compared to the baseline group (very dirty local environment). Moreover, a higher score in sanitation facilities also correlated with increased odds of willingness to receive the NTDs vaccine (aOR = 1.41, 95% CI: 1.21–1.64). The study highlighted key strategies for improving NTDs vaccine uptake in Asian countries, including China, such as fostering positive attitudes toward the vaccine and enhancing perception of infection risks.
DOI: 10.6084/m9.figshare.28551593.v1
title: Attitudes and acceptance of vaccination against neglected tropical diseases: A multi-country study in Asia

description: This study aims to explore the willingness of individuals to be vaccinated against NTDs in Asian countries and China. Between June and December 2023, an anonymous cross-sectional survey was carried out in five Asian countries alongside China. Overall, 48.4% indicated being somewhat willing and 29.2% expressing extreme willingness to receive NTDs vaccination. High attitude scores (adjusted odds ratio [aOR] = 1.54, 95% confidence interval (CI): 11.35–1.75) was associated with higher willingness to be vaccinated against NTDs. The odds of accepting the NTDs vaccine increased among individuals without occupational exposure to NTDs (aOR = 1.46, 95% CI: 1.27–1.68). Those residing in very clean environments exhibited heightened odds of willingness (aOR = 2.94, 95% CI: 2.10–4.11), whereas individuals in somewhat dirty environments demonstrated reduced odds of willingness (aOR = 0.74, 95% CI: 0.56–0.98) compared to the baseline group (very dirty local environment). Moreover, a higher score in sanitation facilities also correlated with increased odds of willingness to receive the NTDs vaccine (aOR = 1.41, 95% CI: 1.21–1.64). The study highlighted key strategies for improving NTDs vaccine uptake in Asian countries, including China, such as fostering positive attitudes toward the vaccine and enhancing perception of infection risks.