cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6731387.v2
title: Satisfaction with access and quality of healthcare services for people with spinal cord injury living in the community

description: <b>Objective:</b> To identify barriers to access healthcare services and reveal determinants of satisfaction with healthcare services in people with chronic spinal cord injury (SCI). <b>Design:</b> Cross-sectional survey. <b>Setting</b>: Community setting in Switzerland. <b>Participants</b>: People with chronic SCI. <b>Interventions</b>: Non-applicable. <b>Outcome Measures</b>: Questionnaire-based evaluation of availability and quality of healthcare services for secondary health conditions, satisfaction with fulfillment of healthcare needs, and preference for care from a hypothetical service provider with limited specialized SCI care expertise but in close proximity over comprehensive care from an existing specialized SCI center located at a greater distance. <b>Results:</b> Close to three-quarter of participants (70%) indicated satisfaction with healthcare services received for SCI related health conditions. Elderly individuals (61+ years old) rated the availability and quality of healthcare 6% to 11% higher than younger individuals. The perceived fulfillment of healthcare needs was lower in people with incomplete paraplegia (odds ratio (OR) 2.11, 95%-credibility interval (CI) 1.18–3.84), chronic pain (OR 1.85, CI 1.12–3.08), insufficient access to long distance transportation (OR 5.81, CI 2.74–12.82), and longer travel distances to specialized SCI centers. <b>Conclusion:</b> Perceived inadequateness of access to healthcare services was partly related to transportation barriers, suggesting that outreach services or support with transportation are possible solutions. People with incomplete paralysis and pain consistently rated the fulfillment of care needs associated with SCI less favorably, pointing to the need for enhanced advocacy for this vulnerable groups.
DOI: 10.6084/m9.figshare.6731387.v1
title: Satisfaction with access and quality of healthcare services for people with spinal cord injury living in the community

description: <b>Objective:</b> To identify barriers to access healthcare services and reveal determinants of satisfaction with healthcare services in people with chronic spinal cord injury (SCI). <b>Design:</b> Cross-sectional survey. <b>Setting</b>: Community setting in Switzerland. <b>Participants</b>: People with chronic SCI. <b>Interventions</b>: Non-applicable. <b>Outcome Measures</b>: Questionnaire-based evaluation of availability and quality of healthcare services for secondary health conditions, satisfaction with fulfillment of healthcare needs, and preference for care from a hypothetical service provider with limited specialized SCI care expertise but in close proximity over comprehensive care from an existing specialized SCI center located at a greater distance. <b>Results:</b> Close to three-quarter of participants (70%) indicated satisfaction with healthcare services received for SCI related health conditions. Elderly individuals (61+ years old) rated the availability and quality of healthcare 6% to 11% higher than younger individuals. The perceived fulfillment of healthcare needs was lower in people with incomplete paraplegia (odds ratio (OR) 2.11, 95%-credibility interval (CI) 1.18–3.84), chronic pain (OR 1.85, CI 1.12–3.08), insufficient access to long distance transportation (OR 5.81, CI 2.74–12.82), and longer travel distances to specialized SCI centers. <b>Conclusion:</b> Perceived inadequateness of access to healthcare services was partly related to transportation barriers, suggesting that outreach services or support with transportation are possible solutions. People with incomplete paralysis and pain consistently rated the fulfillment of care needs associated with SCI less favorably, pointing to the need for enhanced advocacy for this vulnerable groups.
DOI: 10.6084/m9.figshare.6731321
title: Lifetime data set: paired concept counts

description: Paired concept counts from the lifetime data set. 5,364,781 patients in this data set. File format: tab-delimited table; newline terminated. Columns: concept id 1 - Unique numeric code identifying the first of the paired concepts; concept id 2 - Unique numeric code identifying the second of the paired concepts; count - The number of patients with both concepts in this data set; prevalence - The number of patients with both concepts divided by the total number of patients in this data set (1.0 is 100%). Each unique pair of concepts has at most one row, i.e., the same two concepts do not appear in two separate rows. The rows are arranged in ascending order by concept id 1 and concept id 2. Concept id 1 is always the smaller numeric value.
DOI: 10.6084/m9.figshare.6731315
title: Lifetime data set: single concept count

description: Single concept counts from the lifetime data set. 5,364,781 patients in this data set. File format: tab-delimited table; newline terminated. Columns: concept id - Unique numeric code identifying the concept; count - The number of patients with this concept in this data set; prevalence - The number of patients with this concept divided by the total number of patients in this data set (1.0 is 100%). The rows are arranged in ascending order by concept id.
DOI: 10.6084/m9.figshare.6731318
title: 5-year data set: single concept count

description: Single concept counts from the 5-year data set. 1,790,431 patients in this data set. File format: tab-delimited table; newline terminated. Columns: concept id - Unique numeric code identifying the concept; count - The number of patients with this concept in this data set; prevalence - The number of patients with this concept divided by the total number of patients in this data set (1.0 is 100%). The rows are arranged in ascending order by concept id.
DOI: 10.6084/m9.figshare.6731315.v1
title: Lifetime data set: single concept count

description: Single concept counts from the lifetime data set. 5,364,781 patients in this data set. File format: tab-delimited table; newline terminated. Columns: concept id - Unique numeric code identifying the concept; count - The number of patients with this concept in this data set; prevalence - The number of patients with this concept divided by the total number of patients in this data set (1.0 is 100%). The rows are arranged in ascending order by concept id.
DOI: 10.6084/m9.figshare.6731318.v1
title: 5-year data set: single concept count

description: Single concept counts from the 5-year data set. 1,790,431 patients in this data set. File format: tab-delimited table; newline terminated. Columns: concept id - Unique numeric code identifying the concept; count - The number of patients with this concept in this data set; prevalence - The number of patients with this concept divided by the total number of patients in this data set (1.0 is 100%). The rows are arranged in ascending order by concept id.
DOI: 10.6084/m9.figshare.6731309
title: 5-year data set: paired concept counts

description: Paired concept counts from the 5-year data set. 1,790,431 patients in this data set. File format: tab-delimited table; newline terminated. Columns: concept id 1 - Unique numeric code identifying the first of the paired concepts; concept id 2 - Unique numeric code identifying the second of the paired concepts; count - The number of patients with both concepts in this data set; prevalence - The number of patients with both concepts divided by the total number of patients in this data set (1.0 is 100%). Each unique pair of concepts has at most one row, i.e., the same two concepts do not appear in two separate rows. The rows are arranged in ascending order by concept id 1 and concept id 2. Concept id 1 is always the smaller numeric value.
DOI: 10.6084/m9.figshare.6731312
title: Concepts

description: Concept definitions. File format: tab-delimited table; newline terminated. Columns: concept id - Unique numeric code identifying each concept. This is the key concept id referenced in the other files; concept name - The descriptive name of each concept; domain - The OMOP domain of each concept; vocabulary id - The source vocabulary which originally defined the concept (e.g., SNOMED-CT, RxNorm, etc); concept class id - The OMOP concept class; concept code - The identifier from the source vocabulary for this concept.
DOI: 10.6084/m9.figshare.6731273
title: Study of dynamic CT radiomic features to assist the accurate diagnosis of HCC

description: <b>Figure 1 </b>Delineation of an HCC in each of the five phases on CT images<b> (</b>A: plain scan phase (PSP), B: arterial phase (AP), C: portal venous phase (PVP), D: venous phase (VP), E: delayed phase (DP))<b></b> <b>Figure 2</b> The variation trend of the GTV radiomic features throughout the 5 phases <b>Figure 3</b> The comparison of dynamic trends of the CT radiomic features of the GTV and normal liver tissue <b>Figure 4</b> ROC curves of 4 radiomic features in the five phases (A: plain scan phase, B: arterial phase, C: portal venous phase, D: venous phase, E: delayed phase） <b>Table 1</b> The radiomic feature change rate differences between normal liver tissue and the GTV in the different time phases <b>Table 2</b> The AUC values and Youden index of 4 radiomic features in the different phases <b>Table S1</b> The extracted radiomic features in this study
DOI: 10.6084/m9.figshare.6731273.v1
title: Study of dynamic CT radiomic features to assist the accurate diagnosis of HCC

description: <b>Figure 1 </b>Delineation of an HCC in each of the five phases on CT images<b> (</b>A: plain scan phase (PSP), B: arterial phase (AP), C: portal venous phase (PVP), D: venous phase (VP), E: delayed phase (DP))<b></b> <b>Figure 2</b> The variation trend of the GTV radiomic features throughout the 5 phases <b>Figure 3</b> The comparison of dynamic trends of the CT radiomic features of the GTV and normal liver tissue <b>Figure 4</b> ROC curves of 4 radiomic features in the five phases (A: plain scan phase, B: arterial phase, C: portal venous phase, D: venous phase, E: delayed phase） <b>Table 1</b> The radiomic feature change rate differences between normal liver tissue and the GTV in the different time phases <b>Table 2</b> The AUC values and Youden index of 4 radiomic features in the different phases <b>Table S1</b> The extracted radiomic features in this study
DOI: 10.6084/m9.figshare.6731207
title: cDNA libraries (stats).xls

description: summary statistics of cDNA libraries showing RNA integrity numbers, number of raw reads and bases
DOI: 10.6084/m9.figshare.6731207.v1
title: cDNA libraries (stats).xls

description: summary statistics of cDNA libraries showing RNA integrity numbers, number of raw reads and bases
DOI: 10.6084/m9.figshare.6731198.v1
title: Case-study on the effect of model simplification on environmental simulations

description: This is the dataset of a computational experiment aimed to quantify the effects of models simplification on the results of environmental simulations.
DOI: 10.6084/m9.figshare.6731198.v2
title: Study on the effect of model and data model surrogation on environmental simulations

description: This is the dataset of a computational experiment aimed to quantify the effects of the surrogations of a building model and of the data model relative to the building model on design explorations.
DOI: 10.6084/m9.figshare.6731081
title: Boogert et al Song and Network Data Summary from Stress hormones, social associations and song learning in zebra finches

description: This file contains a summary of the data used to run the statistical analyses in this paper.
DOI: 10.6084/m9.figshare.6731081.v1
title: Boogert et al Song and Network Data Summary from Stress hormones, social associations and song learning in zebra finches

description: This file contains a summary of the data used to run the statistical analyses in this paper.
DOI: 10.6084/m9.figshare.6731078
title: Boogert et al Song Similarity Scores from Stress hormones, social associations and song learning in zebra finches

description: This file contains all the song similarity scores for each dyad of males in the study population.
DOI: 10.6084/m9.figshare.6731078.v1
title: Boogert et al Song Similarity Scores from Stress hormones, social associations and song learning in zebra finches

description: This file contains all the song similarity scores for each dyad of males in the study population.
DOI: 10.6084/m9.figshare.6730973
title: Kumar et al., 2018 - JCS

description: Supplemental files _Kumar et al., 2018, JCS
DOI: 10.6084/m9.figshare.6730967
title: KZN pondscape full dataset and species matrices

description: This is the full dataset of species data(dragonflies, beetles and bugs), diversity index data, environmental data and vegetation data. R-ready.
DOI: 10.6084/m9.figshare.6730925
title: High-sensitivity cardiac troponin T for diagnosis of NSTEMI in the elderly emergency department patient: a clinical cohort study

description: <b>Purpose:</b> The aim of this study is to evaluate the impact of age on the diagnostic performance of high-sensitivity troponin T (hsTnT) under routine conditions. <b>Materials and methods:</b> Data of 4118 consecutive emergency department (ED) patients who underwent a routine TnT measurement between 11 October 2012 and 30 November 2013 were analysed. Diagnostic accuracy of hsTnT was compared in four age categories (&lt;50, 50–64, 65–74, ≥75 years of age) for different cut-off values. Primary endpoint was a main hospital diagnosis of NSTEMI. <b>Results:</b> The median age of the study population (<i>n</i> = 4118) was 61 years (IQR: 45–75 years). NSTEMI was diagnosed in 3.3% (<i>n</i> = 136) of all patients. There were significant differences in hsTnT concentrations between age-groups (<i>p</i> p = 0.297). 72.2% of all patients ≥75 years of age (583/808) without NSTEMI had hsTnT concentrations above the 99th percentile of a healthy reference population. Specificity at 14 ng/L was 93.6% (95% CI: 92.12–94.87) in patients below 50 years of age and 27.9% (95% CI: 24.78–31.08) in patients 75 years of age and older. <b>Conclusions:</b> Patients’ age needs to be considered at least one influencing factor on hsTnT concentrations at admission and should be included in the clinical interpretation of hsTnT concentrations for further clinical workup beneath other influencing factors like comorbidities and symptom onset time. The implementation of age-specific cut-off values could be considered for single troponin testing at admission but is associated with an increased risk of underdiagnosis of NSTEMI.
DOI: 10.6084/m9.figshare.6730925.v1
title: High-sensitivity cardiac troponin T for diagnosis of NSTEMI in the elderly emergency department patient: a clinical cohort study

description: <b>Purpose:</b> The aim of this study is to evaluate the impact of age on the diagnostic performance of high-sensitivity troponin T (hsTnT) under routine conditions. <b>Materials and methods:</b> Data of 4118 consecutive emergency department (ED) patients who underwent a routine TnT measurement between 11 October 2012 and 30 November 2013 were analysed. Diagnostic accuracy of hsTnT was compared in four age categories (&lt;50, 50–64, 65–74, ≥75 years of age) for different cut-off values. Primary endpoint was a main hospital diagnosis of NSTEMI. <b>Results:</b> The median age of the study population (<i>n</i> = 4118) was 61 years (IQR: 45–75 years). NSTEMI was diagnosed in 3.3% (<i>n</i> = 136) of all patients. There were significant differences in hsTnT concentrations between age-groups (<i>p</i> p = 0.297). 72.2% of all patients ≥75 years of age (583/808) without NSTEMI had hsTnT concentrations above the 99th percentile of a healthy reference population. Specificity at 14 ng/L was 93.6% (95% CI: 92.12–94.87) in patients below 50 years of age and 27.9% (95% CI: 24.78–31.08) in patients 75 years of age and older. <b>Conclusions:</b> Patients’ age needs to be considered at least one influencing factor on hsTnT concentrations at admission and should be included in the clinical interpretation of hsTnT concentrations for further clinical workup beneath other influencing factors like comorbidities and symptom onset time. The implementation of age-specific cut-off values could be considered for single troponin testing at admission but is associated with an increased risk of underdiagnosis of NSTEMI.
DOI: 10.6084/m9.figshare.6729383
title: R Notebook describing statistical analyses

description: R notebook that outlines statistical tests used in doi: https://doi.org/10.1101/358176. Included is the R markdown file (.Rmd), an html file (.html), and a word file (.docx) with all code used to fit the models. All models are named according to the figure panel that represents the data they are using.<br>
DOI: 10.6084/m9.figshare.6730922
title: Does hypothyroidism augment sun-induced skin damage?

description: <b>Objectives:</b> We investigated the mutual effects of overt hypothyroidism and prolonged sunlight exposure on free radical accumulation and oxidative skin damage. <b>Methods:</b> Free radical accumulation was evaluated by monitoring the transformation of 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) into MTT-formazan. The pro-oxidant enzymes xanthine oxidase (XO) and NADPH-diaphorase were measured in the skin. XO activity was estimated based on the yield of uric acid, while NADPH-diaphorase reactivity was monitored histochemically as an indirect marker of nitric oxide synthase and nitric oxide activity. Cellular damage was determined by malondialdehyde formation, a marker for lipid peroxidation. <b>Results:</b> In the skin of both euthyroid and hypothyroid animals, solar simulated ultraviolet irradiance increased the activity of XO and the NADPHdiaphorase reactivity as a protective response to formation of free radicals, such as reactive oxygen or nitrogen species. These pro-oxidant enzymes diminished in hypothyroid rats. Accumulation of the same amount of free radicals led to similar peroxidation in both hypothyroid and irradiated euthyroid rats. Hypothyroid skin after UV-exposure showed even greater lipid peroxidation. <b>Discussion:</b> The hypothyroid state could be a risk factor for enhanced oxidative skin damage in chronic photo-exposed skin due to oxidative stress. The lipid peroxidation is one of the major pathways by which photo-oxidative stress promotes photocarcinogenesis and photo-aging.
DOI: 10.6084/m9.figshare.6730922.v1
title: Does hypothyroidism augment sun-induced skin damage?

description: <b>Objectives:</b> We investigated the mutual effects of overt hypothyroidism and prolonged sunlight exposure on free radical accumulation and oxidative skin damage. <b>Methods:</b> Free radical accumulation was evaluated by monitoring the transformation of 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) into MTT-formazan. The pro-oxidant enzymes xanthine oxidase (XO) and NADPH-diaphorase were measured in the skin. XO activity was estimated based on the yield of uric acid, while NADPH-diaphorase reactivity was monitored histochemically as an indirect marker of nitric oxide synthase and nitric oxide activity. Cellular damage was determined by malondialdehyde formation, a marker for lipid peroxidation. <b>Results:</b> In the skin of both euthyroid and hypothyroid animals, solar simulated ultraviolet irradiance increased the activity of XO and the NADPHdiaphorase reactivity as a protective response to formation of free radicals, such as reactive oxygen or nitrogen species. These pro-oxidant enzymes diminished in hypothyroid rats. Accumulation of the same amount of free radicals led to similar peroxidation in both hypothyroid and irradiated euthyroid rats. Hypothyroid skin after UV-exposure showed even greater lipid peroxidation. <b>Discussion:</b> The hypothyroid state could be a risk factor for enhanced oxidative skin damage in chronic photo-exposed skin due to oxidative stress. The lipid peroxidation is one of the major pathways by which photo-oxidative stress promotes photocarcinogenesis and photo-aging.
DOI: 10.6084/m9.figshare.6729377
title: Raw data for statistical analyses

description: Each data file is a .txt file named according to the figure panel in doi: https://doi.org/10.1101/358176
DOI: 10.6084/m9.figshare.6729377.v1
title: Raw data for statistical analyses

description: Each data file is a .txt file named according to the figure panel in doi: https://doi.org/10.1101/358176
DOI: 10.6084/m9.figshare.6729347
title: Supplementary Material for: Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

description: <b><i>Background:</i></b> The aim of this study was to analyze the possible association of polymorphic variants of the <i>DRD2</i> and <i>ANKK1</i> genes with suicide attempt in a Mexican population. <b><i>Methods:</i></b> We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of <i>DRD2</i> (rs6275 and rs1799978) and 1 polymorphism of <i>ANKK1</i> (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. <b><i>Results:</i></b> Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56–5.81, <i>p</i> = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37–5.75) as well as males (OR = 3.3; 95% CI 1.01–10.77). <b><i>Conclusion:</i></b> Our results suggest that the rs1800497 variant of the <i>ANKK1</i> gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.
DOI: 10.6084/m9.figshare.6729347.v1
title: Supplementary Material for: Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

description: <b><i>Background:</i></b> The aim of this study was to analyze the possible association of polymorphic variants of the <i>DRD2</i> and <i>ANKK1</i> genes with suicide attempt in a Mexican population. <b><i>Methods:</i></b> We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of <i>DRD2</i> (rs6275 and rs1799978) and 1 polymorphism of <i>ANKK1</i> (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. <b><i>Results:</i></b> Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56–5.81, <i>p</i> = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37–5.75) as well as males (OR = 3.3; 95% CI 1.01–10.77). <b><i>Conclusion:</i></b> Our results suggest that the rs1800497 variant of the <i>ANKK1</i> gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.