cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23584899.v1
title: Children and adolescents with disabilities: challenges in medical training

description: Abstract: Introduction: supporting the constitutional rights of people with disabilities includes meeting new curricular guidelines and requires higher education that considers diversity in different contexts. Thus, the undergraduate curricula of health professionals must meet the multifaceted needs of people with disabilities in a way that transcends the biomedical model and permeates the promotion of an inclusive culture. Attitudes and values about disability often influence people’s behavior, making it imperative to introduce this topic. Aim: the present study aim to describe an approach in the curricula and teachers’ conceptions about children and adolescents with disabilities in medical courses. Method: this exploratory, cross-sectional study with a qualitative approach included the documental analysis of official documents of the courses and official pages of the universities, published until the first semester of 2021 and interviews of teachers participating in the course. The content analysis technique was used for the interview material. Results: the documental analysis pointed in the general topics a direction towards a humanistic formation, while respecting the differences; however, when the topic is the disability, the focus was centered on biological issues. During the interviews, the following topics were identified: 1) The importance of the Unified Health System as a space for medical training; 2) The contribution of the National Curriculum Guidelines in guiding the activities of teachers and highlighting relevant points; 3) Development of teaching activities aimed at children and adolescents with disabilities, based on the teachers’ experiences; 4) Conception about the person with disabilities and teacher training; 5) Teacher training for the development of teaching activities about children and adolescents with disabilities and knowledge about public policies in the area. Conclusions: a weakness was identified in the approach to the subject, with specific insertions on the subject, usually from the perspective of the disease and from the opportunities that arise. Among the teachers, the predominance of the biomedical perspective was identified, as well as the lack of training on the subject and its fragile insertion in academic practice. However, the importance of the topic was recognized and its potential to integrate the curricular matrix in a cross-sectional way.
DOI: 10.6084/m9.figshare.23584913
title: Variabilidade nutricional e física de variedades tradicionais de milho (Zea mays L.) cultivados no vale do Juruá, Acre, Brasil

description: Resumo As variedades tradicionais de milho cultivados pelos agricultores familiares constituem-se em fonte de variabilidade genética e são fundamentais para segurança alimentar. Assim, o presente trabalho tem como objetivo, avaliar, com base em componentes físicos e químicos, o comportamento da variabilidade genética de milho tradicional cultivadas em terra firme e praia, na regional Vale do Juruá, estado do Acre. As características constaram da determinação de matéria seca, material mineral, proteína bruta, extrato etéreo, energia bruta, fibra em detergente neutro, amido e digestibilidade in vitro da matéria seca, vitreosidade e densidade dos grãos. Os dados foram analisados mediante estatística descritiva, associado à análise multivariada de componentes principais (PCA), com auxílio do software R. Por meio da PCA, as variedades cultivadas em terra firme e praia formaram 3 grupos distintos, na qual a vitreosidade nos grãos variou de 73,7% a 79,46%, de modo que, as variedades de grãos avermelhadas apresentaram maior presença de endosperma vítreo e maior densidade, havendo uma correlação forte e positiva entre essas variáveis. Já as variedades de grãos amarelas e amarelas-oranges apresentaram maior aderência a energia, amido e maior digestibilidade. Portanto, as variedades tradicionais cultivadas em terra firme e praia, apresentam variações em relação as análises físicas e químicas.
DOI: 10.6084/m9.figshare.23584913.v1
title: Variabilidade nutricional e física de variedades tradicionais de milho (Zea mays L.) cultivados no vale do Juruá, Acre, Brasil

description: Resumo As variedades tradicionais de milho cultivados pelos agricultores familiares constituem-se em fonte de variabilidade genética e são fundamentais para segurança alimentar. Assim, o presente trabalho tem como objetivo, avaliar, com base em componentes físicos e químicos, o comportamento da variabilidade genética de milho tradicional cultivadas em terra firme e praia, na regional Vale do Juruá, estado do Acre. As características constaram da determinação de matéria seca, material mineral, proteína bruta, extrato etéreo, energia bruta, fibra em detergente neutro, amido e digestibilidade in vitro da matéria seca, vitreosidade e densidade dos grãos. Os dados foram analisados mediante estatística descritiva, associado à análise multivariada de componentes principais (PCA), com auxílio do software R. Por meio da PCA, as variedades cultivadas em terra firme e praia formaram 3 grupos distintos, na qual a vitreosidade nos grãos variou de 73,7% a 79,46%, de modo que, as variedades de grãos avermelhadas apresentaram maior presença de endosperma vítreo e maior densidade, havendo uma correlação forte e positiva entre essas variáveis. Já as variedades de grãos amarelas e amarelas-oranges apresentaram maior aderência a energia, amido e maior digestibilidade. Portanto, as variedades tradicionais cultivadas em terra firme e praia, apresentam variações em relação as análises físicas e químicas.
DOI: 10.6084/m9.figshare.23584878
title: <strong>Range shifts of </strong><em><strong>Aedes aegypti</strong></em><strong> and </strong><em><strong>Ae. albopictus</strong></em>

description: <strong>Range shifts of </strong><em><strong>Aedes aegypti</strong></em><strong> and </strong><em><strong>Ae. albopictus </strong></em><strong>suggest that the latecomer shows a greater invasiveness</strong>
DOI: 10.6084/m9.figshare.23584878.v1
title: <strong>Range shifts of </strong><em><strong>Aedes aegypti</strong></em><strong> and </strong><em><strong>Ae. albopictus</strong></em>

description: <strong>Range shifts of </strong><em><strong>Aedes aegypti</strong></em><strong> and </strong><em><strong>Ae. albopictus </strong></em><strong>suggest that the latecomer shows a greater invasiveness</strong>
DOI: 10.6084/m9.figshare.23544444
title: Epigenomic integrative analysis pinpoint master regulator transcription factors associated with tumorigenesis in squamous cell carcinoma of oral tongue

description: Abstract Head and Neck Cancer (HNC) is a heterogeneous group of cancers, which includes cancers arising in the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. Epidemiological studies have revealed that several factors such as tobacco and alcohol use, exposure to environmental pollutants, viral infection, and genetic factors are risk factors for developing HNC. The squamous cell carcinoma of oral tongue (SCCOT), which is significantly more aggressive than the other forms of oral squamous cell carcinoma, presents a propensity for rapid local invasion and spread, and a high recurrence rate. Dysregulation in the epigenetic machinery of cancer cells might help uncover the mechanisms of SCOOT tumorigenesis. Here, we used DNA methylation changes to identify cancer-specific enhancers that were enriched for specific transcription factor binding sites (TFBS), and potential master regulator transcription factors (MRTF) associated with SCCOT. We identified the activation of MRTFs associated with increased invasiveness, metastasis, epithelial-to-mesenchymal transition, poor prognosis, and stemness. On the other hand, we found the downregulation of MRTFs associated with tumor suppression. The identified MRTFs should be further investigated to clarify their role in oral cancer tumorigenesis and for their potential use as biological markers.
DOI: 10.6084/m9.figshare.23544444.v1
title: Epigenomic integrative analysis pinpoint master regulator transcription factors associated with tumorigenesis in squamous cell carcinoma of oral tongue

description: Abstract Head and Neck Cancer (HNC) is a heterogeneous group of cancers, which includes cancers arising in the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. Epidemiological studies have revealed that several factors such as tobacco and alcohol use, exposure to environmental pollutants, viral infection, and genetic factors are risk factors for developing HNC. The squamous cell carcinoma of oral tongue (SCCOT), which is significantly more aggressive than the other forms of oral squamous cell carcinoma, presents a propensity for rapid local invasion and spread, and a high recurrence rate. Dysregulation in the epigenetic machinery of cancer cells might help uncover the mechanisms of SCOOT tumorigenesis. Here, we used DNA methylation changes to identify cancer-specific enhancers that were enriched for specific transcription factor binding sites (TFBS), and potential master regulator transcription factors (MRTF) associated with SCCOT. We identified the activation of MRTFs associated with increased invasiveness, metastasis, epithelial-to-mesenchymal transition, poor prognosis, and stemness. On the other hand, we found the downregulation of MRTFs associated with tumor suppression. The identified MRTFs should be further investigated to clarify their role in oral cancer tumorigenesis and for their potential use as biological markers.
DOI: 10.6084/m9.figshare.23584917
title: Using computational technologies (Weblab) in an undergraduate medical course as supporting tools for laboratorial practices

description: Abstract: Introduction: Medical Schools sought feasible ways to introduce improvements in the teaching-learning process, specifically in remote teaching, during the period of social distancing enforced by the new Sars-Cov-2 coronavirus pandemic. One of the biggest challenges encountered was the structuring of practical laboratory classes, essential to medical training, in the face of this new reality. The design, development, and installation of a remote automation system, called Weblab, replacing face-to-face practical classes, was presented as a possible alternative for meeting the workload established by the Brazilian Ministry of Education. Experience report: this experiment took place in practical Anatomy classes, in the first semesters of 2020 and 2022. In 2020, there was a need to carry out laboratory activities respecting the social distancing rules. A system with hardware and software was developed for students to perform the activities proposed by the teacher. In this system, the student can position a certain anatomical piece remotely, save images with different views and send them to their e-mail, completing the proposed exercises. Discussion: the experiment provided indications of increased student motivation to execute laboratory activities remotely, in view of the dynamic teacher-student interaction. The results of the qualitative evaluations carried out by 10 students indicated that students found it easy to use the equipment in the experiment. From the students’ perspective, there was also an indication of improvement in the teaching/learning process. However, statistical indications are needed to demonstrate this improvement with the application of quantitative assessments on the course content in control groups, using a larger population and with and without the use of the Weblab. Conclusion: the Weblab Anatomy platform demonstrated that the use of technologies makes it possible to change face-to-face laboratory classes to a remote model, helping to solve the problem of physical distancing, complying with health guidelines to avoid contagion in pandemic periods. Qualitative results show important and positive aspects of this experiment, such as the ease of using the Weblab platform.
DOI: 10.6084/m9.figshare.23584917.v1
title: Using computational technologies (Weblab) in an undergraduate medical course as supporting tools for laboratorial practices

description: Abstract: Introduction: Medical Schools sought feasible ways to introduce improvements in the teaching-learning process, specifically in remote teaching, during the period of social distancing enforced by the new Sars-Cov-2 coronavirus pandemic. One of the biggest challenges encountered was the structuring of practical laboratory classes, essential to medical training, in the face of this new reality. The design, development, and installation of a remote automation system, called Weblab, replacing face-to-face practical classes, was presented as a possible alternative for meeting the workload established by the Brazilian Ministry of Education. Experience report: this experiment took place in practical Anatomy classes, in the first semesters of 2020 and 2022. In 2020, there was a need to carry out laboratory activities respecting the social distancing rules. A system with hardware and software was developed for students to perform the activities proposed by the teacher. In this system, the student can position a certain anatomical piece remotely, save images with different views and send them to their e-mail, completing the proposed exercises. Discussion: the experiment provided indications of increased student motivation to execute laboratory activities remotely, in view of the dynamic teacher-student interaction. The results of the qualitative evaluations carried out by 10 students indicated that students found it easy to use the equipment in the experiment. From the students’ perspective, there was also an indication of improvement in the teaching/learning process. However, statistical indications are needed to demonstrate this improvement with the application of quantitative assessments on the course content in control groups, using a larger population and with and without the use of the Weblab. Conclusion: the Weblab Anatomy platform demonstrated that the use of technologies makes it possible to change face-to-face laboratory classes to a remote model, helping to solve the problem of physical distancing, complying with health guidelines to avoid contagion in pandemic periods. Qualitative results show important and positive aspects of this experiment, such as the ease of using the Weblab platform.
DOI: 10.6084/m9.figshare.23584926
title: Effect of fluoride gels with nano-sized sodium trimetaphosphate on the in vitro remineralization of caries lesions

description: Abstract Objective To evaluate the effects of fluoride (F) gels supplemented with micrometric or nano-sized sodium trimetaphosphate (TMPmicro and TMPnano, respectively) on the in vitro remineralization of caries-like lesions. Methodology Bovine enamel subsurface lesions (n=168) were selected according to their surface hardness (SH) and randomly divided into seven groups (n=24/group): Placebo (without F/TMP), 4,500 ppm F (4500F), 4500F + 2.5% TMPnano (2.5% Nano), 4500F + 5% TMPnano (5% Nano), 4500F + 5% TMPmicro (5% Micro), 9,000 ppm F (9000F), and 12,300 ppm F (Acid gel). The gels were applied in a thin layer for one minute. Half of the blocks were subjected to pH cycling for six days, whereas the remaining specimens were used for loosely- (calcium fluoride; CaF2) and firmly-bound (fluorapatite; FA) fluoride analysis. The percentage of surface hardness recovery (%SHR), area of subsurface lesion (ΔKHN), CaF2, FA, calcium (Ca), and phosphorus (P) on/in enamel were determined. Data (log10-transformed) were subjected to ANOVA and the Student-Newman-Keuls’ test (p&lt;0.05). Results We observed a dose-response relation between F concentrations in the gels without TMP for %SHR and ΔKHN. The 2.5% Nano and 5% Micro reached similar %SHR when compared with 9000F and Acid gels. For ΔKHN, Placebo and 5% Nano gels had the highest values, and 5% Micro, 2.5% Nano, 9000F, and Acid gels, the lowest. All groups had similar retained CaF2 values, except for Placebo and Acid gel. We verified observed an increase in Ca concentrations in nano-sized TMP groups. Regarding P, TMP groups showed similar formation and retention to 9000F and Acid. Conclusion Adding 2.5% nano-sized or 5% micrometric TMP to low-fluoride gels lead to enhanced in vitro remineralization of artificial caries lesions.
DOI: 10.6084/m9.figshare.23584926.v1
title: Effect of fluoride gels with nano-sized sodium trimetaphosphate on the in vitro remineralization of caries lesions

description: Abstract Objective To evaluate the effects of fluoride (F) gels supplemented with micrometric or nano-sized sodium trimetaphosphate (TMPmicro and TMPnano, respectively) on the in vitro remineralization of caries-like lesions. Methodology Bovine enamel subsurface lesions (n=168) were selected according to their surface hardness (SH) and randomly divided into seven groups (n=24/group): Placebo (without F/TMP), 4,500 ppm F (4500F), 4500F + 2.5% TMPnano (2.5% Nano), 4500F + 5% TMPnano (5% Nano), 4500F + 5% TMPmicro (5% Micro), 9,000 ppm F (9000F), and 12,300 ppm F (Acid gel). The gels were applied in a thin layer for one minute. Half of the blocks were subjected to pH cycling for six days, whereas the remaining specimens were used for loosely- (calcium fluoride; CaF2) and firmly-bound (fluorapatite; FA) fluoride analysis. The percentage of surface hardness recovery (%SHR), area of subsurface lesion (ΔKHN), CaF2, FA, calcium (Ca), and phosphorus (P) on/in enamel were determined. Data (log10-transformed) were subjected to ANOVA and the Student-Newman-Keuls’ test (p&lt;0.05). Results We observed a dose-response relation between F concentrations in the gels without TMP for %SHR and ΔKHN. The 2.5% Nano and 5% Micro reached similar %SHR when compared with 9000F and Acid gels. For ΔKHN, Placebo and 5% Nano gels had the highest values, and 5% Micro, 2.5% Nano, 9000F, and Acid gels, the lowest. All groups had similar retained CaF2 values, except for Placebo and Acid gel. We verified observed an increase in Ca concentrations in nano-sized TMP groups. Regarding P, TMP groups showed similar formation and retention to 9000F and Acid. Conclusion Adding 2.5% nano-sized or 5% micrometric TMP to low-fluoride gels lead to enhanced in vitro remineralization of artificial caries lesions.
DOI: 10.6084/m9.figshare.23544453
title: The SARS-CoV-2 mutation landscape is shaped before replication starts

description: Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.
DOI: 10.6084/m9.figshare.23544453.v1
title: The SARS-CoV-2 mutation landscape is shaped before replication starts

description: Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.
DOI: 10.6084/m9.figshare.23584934
title: Elaborating, sharing, narrating: a narrative analysis of three approaches to health communication

description: Abstract Communication, despite being considered a key aspect in medical practice, has not received the corresponding attention both on literature and medical training as has the technological and biomedical aspects. As a reaction to this context emerged fields of knowledge proposing to reflect and strengthen aspects of communication between the physician and the patient. In this article, we perform a narrative analysis of the literature of three of such approaches to communication in health: the Balint Groups, the Patient Centered Care and Narrative-Based Medicine. The study highlights the approximations and distances between these approaches, along with the recognition of the potency of each of them in the different contexts of medical practice.
DOI: 10.6084/m9.figshare.23584934.v1
title: Elaborating, sharing, narrating: a narrative analysis of three approaches to health communication

description: Abstract Communication, despite being considered a key aspect in medical practice, has not received the corresponding attention both on literature and medical training as has the technological and biomedical aspects. As a reaction to this context emerged fields of knowledge proposing to reflect and strengthen aspects of communication between the physician and the patient. In this article, we perform a narrative analysis of the literature of three of such approaches to communication in health: the Balint Groups, the Patient Centered Care and Narrative-Based Medicine. The study highlights the approximations and distances between these approaches, along with the recognition of the potency of each of them in the different contexts of medical practice.
DOI: 10.6084/m9.figshare.23584938
title: Selection of white oat genotypes for contrasting fungicide management conditions

description: Abstract The objective of this work was to select white oat (Avena sativa) genotypes for environments with and without fungicide application, as well as to identify relationships between meteorological variables and agronomic traits. Two experiments were carried out: one without and the other with the use of the tebuconazole fungicide. In each experiment, 26 genotypes were evaluated, conducted during ten years in the same experimental area; cultivation years were considered as one environment. The methodologies of genotype and of the genotypes x environments interaction were used to define the ideal genotype. 'URS Corona' is considered an ideal genotype due to its excellent responses in the environment with tebuconazole. The 'Brisasul', 'IPR Aphrodite', and 'URS Taura' genotypes respond better in the environment without the fungicide. However, based on multitraits, the 'URS Taura' and 'IPR Afrodite' genotypes can be positioned in environments with or without the use of tebuconazole. Genotypes with a rust incidence lower than 15% and a height higher than 93 cm in an environment with a relative humidity lower than 70.75% have a higher grain yield regardless of fungicide use. Greater magnitudes of air temperature and solar radiation result in a higher grain yield of white oat, regardless of fungicide use.
DOI: 10.6084/m9.figshare.23584938.v1
title: Selection of white oat genotypes for contrasting fungicide management conditions

description: Abstract The objective of this work was to select white oat (Avena sativa) genotypes for environments with and without fungicide application, as well as to identify relationships between meteorological variables and agronomic traits. Two experiments were carried out: one without and the other with the use of the tebuconazole fungicide. In each experiment, 26 genotypes were evaluated, conducted during ten years in the same experimental area; cultivation years were considered as one environment. The methodologies of genotype and of the genotypes x environments interaction were used to define the ideal genotype. 'URS Corona' is considered an ideal genotype due to its excellent responses in the environment with tebuconazole. The 'Brisasul', 'IPR Aphrodite', and 'URS Taura' genotypes respond better in the environment without the fungicide. However, based on multitraits, the 'URS Taura' and 'IPR Afrodite' genotypes can be positioned in environments with or without the use of tebuconazole. Genotypes with a rust incidence lower than 15% and a height higher than 93 cm in an environment with a relative humidity lower than 70.75% have a higher grain yield regardless of fungicide use. Greater magnitudes of air temperature and solar radiation result in a higher grain yield of white oat, regardless of fungicide use.