cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6865289.v1
title: Supplementary Material for: A 2018 Italian and Romanian Survey on Subclinical Hypothyroidism in Pregnancy

description: <b><i>Objectives:</i></b> Pregnancy induces changes in thyroid function, and thyroid dysfunction during gestation is associated with adverse outcomes. We examined the management of subclinical hypothyroidism and chronic autoimmune thyroiditis in pregnancy among Italian and Romanian endocrinologists. <b><i>Methods:</i></b> Members of the Associazione Medici Endocrinologi (AME) and Romanian Society of Endocrinology (RSE) were invited to participate in a web-based survey investigating the topic. <b><i>Results:</i></b> A total of 902 individuals participated in the survey, 759 of whom completed all sections. Among the respondents, 85.1% were aware of the 2017 American Thyroid Association guidelines about thyroid disease and pregnancy, and 82.9% declared that thyroid-stimulating hormone (TSH) screening at the beginning of pregnancy should be warranted. In a patient negative for peroxidase antibodies, 53.6% considered 2.5 mIU/L and 26.2% considered 4.0 mIU/L as the upper normal limit of TSH, and 50% would treat a patient with TSH 3.5 mIU/L with levothyroxine. About 20% did not suggest iodine supplementation. Isolated hypothyroxinemia detected in the first trimester would be treated by 40.8%. In patients undergoing ovarian stimulation, a TSH &lt; 2.5 mIU/L would be targeted by 70%. <b><i>Conclusions:</i></b> Respondents globally appeared well informed about the management of thyroid autoimmunity and subclinical hypothyroidism in pregnancy. A more aggressive attitude in implementing iodine supplementation would be desirable. Most endocrinologists were convinced about an evident association between mild thyroid impairment and adverse outcomes in pregnancy, thus using a TSH value of 2.5 mIU/L as the threshold for diagnosing hypothyroidism and starting levothyroxine in pregnant women.
DOI: 10.6084/m9.figshare.6865268
title: BIOLINV Point Count Data Archive

description: Number of common mynas observed on each zone (10m concentric circles from the experimenter) at each point-count, both before and after a distress call playback took place. <br><br>See details of methods in Article and Supplementary materials : https://doi.org/10.1007/s10530-018-1798-9<br><br><b>region</b> - Region where sampling took place : "larger Sydney" or "larger Canberra"<br><b>locality</b> - Localities of different trapping pressures were sampled in each region<br><b>trap_pressure</b> - Trapping pressure of the locality, either high (&gt;10 mynas removed per year per 10,000 inhabitants) or low. <br><b>area</b> - sampling area (2x2km zone)<br><b>plot</b> - point-count plot (50m circle)<br><b>zone</b> - 10m wide concentric circles from the centre of the plot: z0 (0 to 10m from centre), z1 (10 to 20m), z2 (20 to 30m), z3 (30 to 40m), z4 (40 to 50m), z5 (50m and beyond)<br><b>day</b> - day where the sampling took place (day 1 = 01/06/2012)<br><b>season</b> - breed (beginning of breeding period, September to October), non-b (before the breeding period, June to September)<br><b>habitat</b> - URBAN (high density housing and commercial and industrial areas), RESID (residential areas, low rise buildings with gardens), PARK (wooded and open parkland). Defined by the level of coverage of the plot.<br><b>suntime</b> - time to sunset in hours<br><b>temp</b> - temperature observed during the closest measurement (celsius degrees)<br><b>seen.before</b> - number of mynas observed before the playback in each zone of each plots<br><b>seen.after</b> - number of mynas observed during and after the playback in each zone of each plot<br> <br>
DOI: 10.6084/m9.figshare.6865283
title: Supranational data.rar

description: This is the data set for the article on fiscal risk sharing mechanism for the euro area
DOI: 10.6084/m9.figshare.6865283.v1
title: Supranational data.rar

description: This is the data set for the article on fiscal risk sharing mechanism for the euro area
DOI: 10.6084/m9.figshare.6865262
title: Supplementary Material for: Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway

description: <b><i>Background/Aims:</i></b> The current study aimed to investigate the role by which fibronectin 1 (FN1) influences the cell cycle, senescence and apoptosis in human glioma cells through the PI3K/ AKT signaling pathway. <b><i>Methods:</i></b> Differentially expressed genes (DEGs) were identified based on gene expression data (GSE12657, GSE15824 and GSE45921 datasets) and probe annotation files from Gene Expression Omnibus. The DEGs were identified in connection with gene ontology (GO) enrichment analysis and with the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The positive expression of the FN1 protein was detected by immunohistochemistry. The glioma cell lines U251 and T98G were selected and assigned into blank, negative control (NC) and siRNA-FN1 groups. A dual luciferase reporter gene assay was used to investigate the effects of FN1 on transcriptional activity through the PI3K/AKT signaling pathway. An MTT assay was applied for the detection of cell proliferation, while flow cytometry was employed for cell cycle stage and cellular apoptosis detection. β-galactosidase staining was utilized to detect cellular senescence, a scratch test was applied to evaluate cell migration, and a transwell assay was used to analyze cell invasion. Western blotting and qRT-PCR methods were used to detect the protein and mRNA expression levels, respectively, of the FN1 gene and the related genes in the PI3K/AKT pathway (PI3K, AKT and PTEN), the cell cycle (pRb, CDK4 and Cyclin D1) and cell senescence (p16 and p21) among the collected tissues and cells. <b><i>Results:</i></b> GSE12657 profiling revealed FN1 to be the most upregulated gene in glioma. Regarding the GSE12657 and GSE15824 datasets, FN1 gene expression was higher in glioma tissues than in normal tissues. GO enrichment analysis and KEGG pathway enrichment analysis indicated that FN1 is involved in the synthesis of extracellular matrix (ECM) components and the PI3K/AKT signaling pathway. Verification was provided, indicating the role played by the FN1 gene in the regulation of the PI3K/AKT signaling pathway, as silencing the FN1 gene was found to inhibit cell proliferation, promote cell apoptosis and senescence, and reduce migration and invasion through the down-regulation of FN1 gene expression and disruption of the PI3K-AKT signaling pathway. <b><i>Conclusion:</i></b> The findings of this study provide evidence highlighting the prominent role played by FN1 in stimulating glioma growth, invasion, and survival through the activation of the PI3K/AKT signaling pathway.
DOI: 10.6084/m9.figshare.6865268.v1
title: BIOLINV Point Count Data Archive

description: Number of common mynas observed on each zone (10m concentric circles from the experimenter) at each point-count, both before and after a distress call playback took place. <br><br>See details of methods in Article and Supplementary materials : https://doi.org/10.1007/s10530-018-1798-9<br><br><b>region</b> - Region where sampling took place : "larger Sydney" or "larger Canberra"<br><b>locality</b> - Localities of different trapping pressures were sampled in each region<br><b>trap_pressure</b> - Trapping pressure of the locality, either high (&gt;10 mynas removed per year per 10,000 inhabitants) or low. <br><b>area</b> - sampling area (2x2km zone)<br><b>plot</b> - point-count plot (50m circle)<br><b>zone</b> - 10m wide concentric circles from the centre of the plot: z0 (0 to 10m from centre), z1 (10 to 20m), z2 (20 to 30m), z3 (30 to 40m), z4 (40 to 50m), z5 (50m and beyond)<br><b>day</b> - day where the sampling took place (day 1 = 01/06/2012)<br><b>season</b> - breed (beginning of breeding period, September to October), non-b (before the breeding period, June to September)<br><b>habitat</b> - URBAN (high density housing and commercial and industrial areas), RESID (residential areas, low rise buildings with gardens), PARK (wooded and open parkland). Defined by the level of coverage of the plot.<br><b>suntime</b> - time to sunset in hours<br><b>temp</b> - temperature observed during the closest measurement (celsius degrees)<br><b>seen.before</b> - number of mynas observed before the playback in each zone of each plots<br><b>seen.after</b> - number of mynas observed during and after the playback in each zone of each plot<br> <br>
DOI: 10.6084/m9.figshare.6865262.v1
title: Supplementary Material for: Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway

description: <b><i>Background/Aims:</i></b> The current study aimed to investigate the role by which fibronectin 1 (FN1) influences the cell cycle, senescence and apoptosis in human glioma cells through the PI3K/ AKT signaling pathway. <b><i>Methods:</i></b> Differentially expressed genes (DEGs) were identified based on gene expression data (GSE12657, GSE15824 and GSE45921 datasets) and probe annotation files from Gene Expression Omnibus. The DEGs were identified in connection with gene ontology (GO) enrichment analysis and with the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The positive expression of the FN1 protein was detected by immunohistochemistry. The glioma cell lines U251 and T98G were selected and assigned into blank, negative control (NC) and siRNA-FN1 groups. A dual luciferase reporter gene assay was used to investigate the effects of FN1 on transcriptional activity through the PI3K/AKT signaling pathway. An MTT assay was applied for the detection of cell proliferation, while flow cytometry was employed for cell cycle stage and cellular apoptosis detection. β-galactosidase staining was utilized to detect cellular senescence, a scratch test was applied to evaluate cell migration, and a transwell assay was used to analyze cell invasion. Western blotting and qRT-PCR methods were used to detect the protein and mRNA expression levels, respectively, of the FN1 gene and the related genes in the PI3K/AKT pathway (PI3K, AKT and PTEN), the cell cycle (pRb, CDK4 and Cyclin D1) and cell senescence (p16 and p21) among the collected tissues and cells. <b><i>Results:</i></b> GSE12657 profiling revealed FN1 to be the most upregulated gene in glioma. Regarding the GSE12657 and GSE15824 datasets, FN1 gene expression was higher in glioma tissues than in normal tissues. GO enrichment analysis and KEGG pathway enrichment analysis indicated that FN1 is involved in the synthesis of extracellular matrix (ECM) components and the PI3K/AKT signaling pathway. Verification was provided, indicating the role played by the FN1 gene in the regulation of the PI3K/AKT signaling pathway, as silencing the FN1 gene was found to inhibit cell proliferation, promote cell apoptosis and senescence, and reduce migration and invasion through the down-regulation of FN1 gene expression and disruption of the PI3K-AKT signaling pathway. <b><i>Conclusion:</i></b> The findings of this study provide evidence highlighting the prominent role played by FN1 in stimulating glioma growth, invasion, and survival through the activation of the PI3K/AKT signaling pathway.
DOI: 10.17028/rd.lboro.6865238
title: Divergence and convergence in graphic design and communication design: conversation cue cards

description: These cue cards were prepared for a 'Conversation' workshop at the Design Research Society Conference, University of Limerick, Ireland, 25–28th June 2018.<br>The cards are made available here as a resource for further use by session participants and others who might wish to facilitate a similar workshop. Furthermore, and where applicable, each card is fully referenced for those who want to further research the difference and similarity between Graphic Design and Communication Design. <br>The objective of the workshop was to establish where there are converging and diverging interests between Graphic Design and Communication Design, and where there needs to be further research into differentiation that challenges assumptions about practice, theory, and history, in these fields. The cards were designed to stimulate discussion about the artefacts, activities, practises, functions, competencies, and opinions about the supposed link between these fields.<br><br>The session was convened by Robert Harland (Lead) (Loughborough University), Veronika Kelly (University of South Australia), Karel van der Waarde (Swinburne University of Technology and Basel School of Design, and Eamon Spelman (Limerick Institute of Technology). <br><br>A report on the workshop can be located in the Conversations section of the DRS2018 website at: http://www.drs2018limerick.org/ <br>
DOI: 10.6084/m9.figshare.6865247
title: Code and data to reproduce "Predicting parasite associations and community composition using joint species distribution models"

description: Code and data to reproduce<br>&gt; Dallas, T, A Laine, O Ovaskainen. 2018. Predicting parasite associations and community composition using joint species distribution models. <br>Please cite the original data provider if using the Sevilleta LTER data <br>&gt; Duszyinski, D. (2010) Rodent Parasite Data for the Sevilleta National Wildlife Refuge, New Mexico (1990-1998). Long Term Ecological Research Network, http://dx.doi.org/10.6073/pasta/b739d2c75e142f5742b7bfe74c97d5c1
DOI: 10.17028/rd.lboro.6865238.v1
title: Divergence and convergence in graphic design and communication design: conversation cue cards

description: These cue cards were prepared for a 'Conversation' workshop at the Design Research Society Conference, University of Limerick, Ireland, 25–28th June 2018.<br>The cards are made available here as a resource for further use by session participants and others who might wish to facilitate a similar workshop. Furthermore, and where applicable, each card is fully referenced for those who want to further research the difference and similarity between Graphic Design and Communication Design. <br>The objective of the workshop was to establish where there are converging and diverging interests between Graphic Design and Communication Design, and where there needs to be further research into differentiation that challenges assumptions about practice, theory, and history, in these fields. The cards were designed to stimulate discussion about the artefacts, activities, practises, functions, competencies, and opinions about the supposed link between these fields.<br><br>The session was convened by Robert Harland (Lead) (Loughborough University), Veronika Kelly (University of South Australia), Karel van der Waarde (Swinburne University of Technology and Basel School of Design, and Eamon Spelman (Limerick Institute of Technology). <br><br>A report on the workshop can be located in the Conversations section of the DRS2018 website at: http://www.drs2018limerick.org/ <br>
DOI: 10.6084/m9.figshare.6865163
title: Computed HCTSA matrices for the UEA/UCR 2018 time-series classification tasks

description: Using the <i>hctsa</i> toolbox v0.97 (link in References below), we computed 7,500+ time-series features on each of the time-series classification tasks contained in the UEA/UCR Time Series Classification Repository. This repository provides the computed <i>hctsa</i> output files (.mat-files) for each classification task.<br>We used the computed feature matrices to select a small subset of 22 <i>hctsa</i> estimators (termed <i>catch22</i>) that were the most useful for the UEA/UCR datasets:C.H. Lubba, S.S. Sethi, P. Knaute, S.R. Schultz, B.D. Fulcher, N.S. Jones. <i>catch22</i>: CAnonical Time-series CHaracteristics. arXiv (2019). https://arxiv.org/abs/1901.10200<br><br>The matrices can be read in from Python as well using the Matlab_IO interface for which examples can be found in our selection pipeline for <i>catch22</i> ("op_importance" in References) and in the "hctsaAnalysisPython" GitHub repository.
DOI: 10.6084/m9.figshare.6865031
title: Climate, human influence, and the distribution limits of the invasive European earwig, Forficula auricularia, in Australia

description: Dataset of new Australian occurrences of Forficula auricularia (European Earwig), collected from Australian grains growing regions.<br><br>Please note these data have been rescaled to the 10' resolution used in the manuscript to anonymize the data. <br><br> Complete R code for SDM and niche analyses in the paper.<br>
DOI: 10.6084/m9.figshare.6865031.v1
title: Climate, human influence, and the distribution limits of the invasive European earwig, Forficula auricularia, in Australia

description: Dataset of new Australian occurrences of Forficula auricularia (European Earwig), collected from Australian grains growing regions.<br><br>Please note these data have been rescaled to the 10' resolution used in the manuscript to anonymize the data. <br><br> Complete R code for SDM and niche analyses in the paper.<br>
DOI: 10.6084/m9.figshare.6864986
title: Supplementary Material for: General Anesthesia may have Similar Outcomes with Conscious Sedation in Thrombectomy Patients with Acute Ischemic Stroke: A Real-World Registry in China

description: <b><i>Background and Purpose:</i></b> Clinical trials showed that anesthesia may not influence the functional outcome in stroke patients with endovascular therapy; however, data are lacking in China. Using real-world registry data, our study aims to compare the effects of general anesthesia or conscious sedation on functional outcomes in stroke patients treated with thrombectomy in China. <b><i>Methods:</i></b> Consecutive patients with acute anterior circulation stroke receiving thrombectomy in 21 stroke centers between January 2014 and June 2016 were included in this study. The propensity score analysis with 1: 1 ratio was used to match the baseline variables between patients with general anesthesia and the conscious sedation. The 90-day modified Rankin Scale (mRS), symptomatic intracranial hemorrhage (sICH), and death were compared between groups. <b><i>Results:</i></b> Of the 698 patients undergoing endovascular treatment, 138 were treated with general anesthesia and 560 with conscious sedation. After propensity score matching, 114 general anesthesia and 114 conscious sedation patients were matched. The proportions of patients with 90-day mRS 0–2 were not significantly different between general anesthesia and conscious sedation groups (41.2% [47/114] vs. 46.5% [53/114], <i>p</i> = 0.470), nor were the rates of sICH (21.9% [25/114] vs. 12.3% [14/114], <i>p</i> = 0.072) and 90-day mortality (31.6% [36/114] vs. 21.9% [25/114], <i>p</i> = 0.145). <b><i>Conclusion:</i></b> Anesthesia patterns may have no significant impacts on clinical outcomes in patients with acute anterior circulation occlusion stroke undergoing endovascular treatment in the real-world practice in China.
DOI: 10.6084/m9.figshare.6864980
title: Long noncoding RNA expression in the cervix mid-pregnancy is associated with the length of gestation at delivery

description: Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of gestation. However, no study has examined the role of long noncoding RNAs (lncRNAs) in the cervix during pregnancy. To determine whether expression of lncRNAs is associated with length of gestation at delivery, we analyzed RNA from cervical swabs obtained from 78 women during pregnancy (mean 15.5, SD 5.0, weeks of gestation) who were participating in the Spontaneous Prematurity and Epigenetics of the Cervix (SPEC) Study in Boston, MA, USA. We used a PCR-based platform and found that 9 lncRNAs were expressed in at least 50% of the participants. Of these, a doubling of the expression of <i>TUG1, TINCR</i>, and <i>FALEC</i> was associated with shorter lengths of gestation at delivery [2.8 (95% CI: 0.31, 5.2); 3.3 (0.22, 6.3); and 4.5 (7.3, 1.6) days shorter respectively]. Of the lncRNAs analyzed, none was statistically associated with preterm birth, but expression of <i>FALEC</i> was 2.6-fold higher in women who delivered preterm vs. term (<i>P </i>= 0.051). These findings demonstrate that lncRNAs can be measured in cervical samples obtained during pregnancy and are associated with subsequent length of gestation at delivery. Further, this study supports future work to replicate these findings in other cohorts and perform mechanistic studies to determine the role of lncRNAs in the cervix during pregnancy.
DOI: 10.6084/m9.figshare.6864980.v2
title: Long noncoding RNA expression in the cervix mid-pregnancy is associated with the length of gestation at delivery

description: Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of gestation. However, no study has examined the role of long noncoding RNAs (lncRNAs) in the cervix during pregnancy. To determine whether expression of lncRNAs is associated with length of gestation at delivery, we analyzed RNA from cervical swabs obtained from 78 women during pregnancy (mean 15.5, SD 5.0, weeks of gestation) who were participating in the Spontaneous Prematurity and Epigenetics of the Cervix (SPEC) Study in Boston, MA, USA. We used a PCR-based platform and found that 9 lncRNAs were expressed in at least 50% of the participants. Of these, a doubling of the expression of <i>TUG1, TINCR</i>, and <i>FALEC</i> was associated with shorter lengths of gestation at delivery [2.8 (95% CI: 0.31, 5.2); 3.3 (0.22, 6.3); and 4.5 (7.3, 1.6) days shorter respectively]. Of the lncRNAs analyzed, none was statistically associated with preterm birth, but expression of <i>FALEC</i> was 2.6-fold higher in women who delivered preterm vs. term (<i>P </i>= 0.051). These findings demonstrate that lncRNAs can be measured in cervical samples obtained during pregnancy and are associated with subsequent length of gestation at delivery. Further, this study supports future work to replicate these findings in other cohorts and perform mechanistic studies to determine the role of lncRNAs in the cervix during pregnancy.
DOI: 10.6084/m9.figshare.6864980.v1
title: Long noncoding RNA expression in the cervix mid-pregnancy is associated with the length of gestation at delivery

description: Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of gestation. However, no study has examined the role of long noncoding RNAs (lncRNAs) in the cervix during pregnancy. To determine whether expression of lncRNAs is associated with length of gestation at delivery, we analyzed RNA from cervical swabs obtained from 78 women during pregnancy (mean 15.5, SD 5.0, weeks of gestation) who were participating in the Spontaneous Prematurity and Epigenetics of the Cervix (SPEC) Study in Boston, MA, USA. We used a PCR-based platform and found that 9 lncRNAs were expressed in at least 50% of the participants. Of these, a doubling of the expression of <i>TUG1, TINCR</i>, and <i>FALEC</i> was associated with shorter lengths of gestation at delivery [2.8 (95% CI: 0.31, 5.2); 3.3 (0.22, 6.3); and 4.5 (7.3, 1.6) days shorter respectively]. Of the lncRNAs analyzed, none was statistically associated with preterm birth, but expression of <i>FALEC</i> was 2.6-fold higher in women who delivered preterm vs. term (<i>P</i>=0.051). These findings demonstrate that lncRNAs can be measured in cervical samples obtained during pregnancy and are associated with subsequent length of gestation at delivery. Further, this study supports future work to replicate these findings in other cohorts and perform mechanistic studies to determine the role of lncRNAs in the cervix during pregnancy.