cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/6f1-f1p-sa6
title: Juncaceae Juss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/x99-9vy-e3p
title: Iridaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/5x0-sc3-j4z
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/h9x-j2f-f53
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/b23-mfc-t39
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/jzw-e9a-a8p
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mex-s3p-29v
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mse-6xg-ngq
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/tqz-h3k-5tl
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/97w-3mn-12x
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/av5-6d1-7ln
title: Isopogon linearis Meisn.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/7bk-sem-vte
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/xv9-l9e-xj9
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.9sqnzy
title: Occurrence Download

description: A dataset containing 211348 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pionus menstruus"
 ]
}

 The dataset includes 211348 records from 328 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001624-250710112747441/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/8xx-xl8-cba
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/e5b-grz-vkp
title: Isopogon tridens (Meisn.) F. Muell.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/3t4-l2n-v0v
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ptj-h5x-w3c
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/eyg-w20-n1l
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/pmd-pxb-jea
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/tjl-cyq-bmw
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.21227/72kj-2h08
title: "ESCI_Products_dataset_for_paper_submission"

description: "This data is uploaded for submission of paper titled \"GAHS for E-Commerce: A Generalized Authority-Hub Score for Evaluating Product Search Query Expansion on Unseen Queries\" into special Issue on Custom AI Models and Composite AI Systems for Mission-Critical and Complex Enterprise Applications, Internet Computing Magazine."
DOI: 10.3535/3nl-qqj-ban
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/y5d-rq2-tjd
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/nrx-k3e-7r9
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/x5d-dn5-dsm
title: Cyperaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/k35-2s8-4hj
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/vxk-66z-jvq
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/s16-m7z-636
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/9nj-hyk-3jh
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/q7x-qez-a3y
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/1qr-1fw-cqm
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/yp9-yhh-ssl
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/4a1-bwd-c04
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/84p-m49-t7c
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mk0-ldt-f8b
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/zc3-bhj-1w0
title: Isatis costata C. A. Mey.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/b3g-nmk-w9g
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/p21-ck1-5g8
title: Isatis emarginata Kar. & Kir.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/4n2-wpe-1zk
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/629-efe-0la
title: Isatis glauca subsp. exauriculata (Bornm.) Davis

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/964-dar-ehb
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.smdswr
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Habia rubica)",
 "Country is one of (Bermuda, Canada, Greenland, Saint Pierre and Miquelon, United States of America)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001657-250710112747441/datasets/export for details.
DOI: 10.3535/cna-qjh-f5m
title: Scrophulariaceae Juss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/kqy-hth-bzg
title: Iriartella setigera (Mart.) H.Wendl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.fp6ehk
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Habia rubica)",
 "Country is one of (Afghanistan, Armenia, Azerbaijan, Bahrain, Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Cyprus, Georgia, Hong Kong, India, Indonesia, Iran (Islamic Republic of), Iraq, Israel, Japan, Jordan, Kazakhstan, Korea (Democratic People’s Republic of), Korea, Republic of, Kuwait, Kyrgyzstan, Lao People’s Democratic Republic, Lebanon, Macao, Malaysia, Maldives, Mongolia, Myanmar, Nepal, Oman, Pakistan, Palestine, State of, Philippines, Qatar, Saudi Arabia, Singapore, Sri Lanka, Syrian Arab Republic, Tajikistan, Thailand, Timor-Leste, Türkiye, Turkmenistan, United Arab Emirates, Uzbekistan, Viet Nam, Yemen)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001659-250710112747441/datasets/export for details.
DOI: 10.3535/6ev-f8e-pqe
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/7qz-kb4-rm3
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/57t-s5j-a2h
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/qbm-312-qsx
title: Isatis bitlisica Davis

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/2qx-8a1-f9n
title: Indigofera L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/lgy-sf6-pa4
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/2ph-dv6-5yw
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wzj-s4v-zln
title: Isatis cappadocica Desv.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mh9-mwn-8f9
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ysc-1lw-b87
title: Isatis lusitanica L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/kbk-mz8-rjm
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/lme-s3j-c70
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hmv-mpq-vq0
title: Illigera trifoliata (Griff.) Dunn

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/m0c-9kj-vc4
title: Illigera trifoliata (Griff.) Dunn

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/edx-rf1-5zz
title: Isatis rugulosa Bunge ex Boiss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/y59-dkj-at3
title: Iriartella stenocarpa Burret

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/9dn-323-e74
title: Isatis frigida Boiss. & Kotschy

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/pef-t7h-099
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/2nm-xbe-55a
title: Isatis latisiliqua Steven

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bpm-mxq-12h
title: Illigera cordata Dunn

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/3a2-lt6-1py
title: Illigera luzonensis (C. Presl) Merr.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/g2a-qj1-ne1
title: Apiaceae Lindl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wnp-d6d-fmt
title: Orchidaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.57760/sciencedb.27681
title: Effects of Elastic-Band Resistance Training on Cognitive-Physical Functions in Older Adults with Motoric Cognitive Risk Syndrome: A Randomized Controlled Trial
title: Effects of Elastic-Band Resistance Training on Cognitive-Physical Functions in Older Adults with Motoric Cognitive Risk Syndrome: A Randomized Controlled Trial

description: This video demonstrates the standardized resistance band training protocol implemented in a randomized controlled trial (Registration: ChiCTR2200059094) investigating the effects of elastic-band resistance exercise on cognitive-physical function in older adults with Motoric Cognitive Risk Syndrome (MCR). The intervention targets to assess the effectiveness in slowing the progression of MCR in older adults.
description: This video demonstrates the standardized resistance band training protocol implemented in a randomized controlled trial (Registration: ChiCTR2200059094) investigating the effects of elastic-band resistance exercise on cognitive-physical function in older adults with Motoric Cognitive Risk Syndrome (MCR). The intervention targets to assess the effectiveness in slowing the progression of MCR in older adults.
DOI: 10.3535/fgp-vw8-r0h
title: Liliaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/fkn-ear-zf9
title: Isatis leuconeura Boiss. & Buhse

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/fkq-030-2za
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/xe6-y1k-q35
title: Rosaceae Juss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hsy-92z-1ln
title: Isachne albens var. buettneri (Hack.) Veldkamp

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ze7-q4r-v07
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/nj4-c2f-d0v
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/n0q-fkb-c8p
title: Coelachne simpliciuscula (Wight & Arn. ex Steud.) Munro ex Benth.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wme-jv7-lnh
title: Cyperaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/s4y-zzd-pyd
title: Ixophorus unisetus (J.Presl) Schltdl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/sbr-cxy-tj8
title: Asteraceae Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/l31-zh8-e3r
title: Cyperaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/r2b-hsw-p66
title: Cyperaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/24g-wjx-f7h
title: Cyperaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/83j-hyr-qm5
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wlw-x2e-geh
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/f07-xdp-4jv
title: Ipomoea fulvicaulis Boiss. ex Hallier fil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/q1v-cm6-yq2
title: Asteraceae Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/d7q-lg5-55f
title: Asteraceae Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/kcg-tfe-1b0
title: Asteraceae Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/peb-yvm-1h7
title: Lamiaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/vj6-gqn-5ml
title: Asteraceae Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/j06-bwr-qz0
title: Isachne mauritiana Kunth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/zhs-l2n-wfb
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/106-bf0-f4n
title: Lamiaceae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/4hl-zh4-w7q
title: Isachne mauritiana Kunth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/d9k-bc9-hx5
title: Myrtaceae Juss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/438-76y-lft
title: Isachne guineensis Stapf & C.E.Hubb.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/894-nrz-qsc
title: Isachne R.Br.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/7a1-qng-vs7
title: Isachne kiyalaensis Robyns

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/kh9-aqf-bl2
title: Isachne R.Br.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/3yk-s7a-qka
title: Asteraceae Dumort.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/4p0-rgr-g0w
title: Ichnanthus calvescens var. scabrior Döll

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/gmt-7h3-rae
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/4vj-lng-jn7
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/f90-87b-4eg
title: Apiaceae Lindl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/b4m-r4a-q7w
title: Scrophulariaceae Juss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bc2-sxb-9fb
title: Indigofera L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/nec-bh8-e72
title: Indigofera nephrocarpa Balf.f.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/s72-ddk-hsm
title: Apiaceae Lindl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.57760/sciencedb.27643
title: Enterohemorrhagic Escherichia coli Targets Annexin A6 and ATG16L1 to Inhibit Autophagy and Induce Inflammation
title: Enterohemorrhagic Escherichia coli Targets Annexin A6 and ATG16L1 to Inhibit Autophagy and Induce Inflammation

description: Autophagy is a critical host defense mechanism against pathogens; however, enterohemorrhagic Escherichia coli (EHEC) O157:H7 exploits it to establish infection. Here, we reveal how EHEC’s effector EspF collaborates with host Annexin A6 (ANXA6) to suppress autophagy and drive inflammation. CRISPR/Cas9-mediated ANXA6 knockout in intestinal epithelial cells reversed EHEC-induced autophagic inhibition, as evidenced by elevated LC3B-II levels and reduced p62 accumulation. Mechanistically, EspF stabilizes ANXA6 to disrupt PI3K/mTOR signaling and impair autophagosome formation, whereas ANXA6 suppresses the expression of ATG16L1, a key autophagy regulator. EHEC infection triggered IL-1β hypersecretion in macrophages, which was coupled with NF-κB pathway hyperactivation via IκBα/p65 phosphorylation. In vivo, EHEC infection upregulated intestinal ANXA6 expression, correlating with mucosal inflammation and barrier dysfunction. Crucially, ANXA6/ATG16L1 axis disruption created a self-reinforcing cycle of impaired autophagy, bacterial persistence, and inflammatory escalation. Our findings identify ANXA6 as a context-dependent autophagy modulator and ATG16L1 as a novel EHEC target, providing mechanistic insights into EHEC pathogenesis.
description: Autophagy is a critical host defense mechanism against pathogens; however, enterohemorrhagic Escherichia coli (EHEC) O157:H7 exploits it to establish infection. Here, we reveal how EHEC’s effector EspF collaborates with host Annexin A6 (ANXA6) to suppress autophagy and drive inflammation. CRISPR/Cas9-mediated ANXA6 knockout in intestinal epithelial cells reversed EHEC-induced autophagic inhibition, as evidenced by elevated LC3B-II levels and reduced p62 accumulation. Mechanistically, EspF stabilizes ANXA6 to disrupt PI3K/mTOR signaling and impair autophagosome formation, whereas ANXA6 suppresses the expression of ATG16L1, a key autophagy regulator. EHEC infection triggered IL-1β hypersecretion in macrophages, which was coupled with NF-κB pathway hyperactivation via IκBα/p65 phosphorylation. In vivo, EHEC infection upregulated intestinal ANXA6 expression, correlating with mucosal inflammation and barrier dysfunction. Crucially, ANXA6/ATG16L1 axis disruption created a self-reinforcing cycle of impaired autophagy, bacterial persistence, and inflammatory escalation. Our findings identify ANXA6 as a context-dependent autophagy modulator and ATG16L1 as a novel EHEC target, providing mechanistic insights into EHEC pathogenesis.
DOI: 10.3535/6ec-fhr-x01
title: Apiaceae Lindl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/1z6-sdp-jda
title: Caryophyllaceae Juss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/5a5-43b-3fq
title: Brassicaceae Burnett

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/6k4-lky-2vf
title: Plantae

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/gla-rfl-m1a
title: Indigofera cordifolia B.Heyne ex Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.