cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9599210
title: Inhibition of Zika Virus Replication by Synthetic Bis-Naphthoquinones

description: Zika virus (ZIKV) is a mosquito-borne pathogen which is a current global public health concern. There are currently no approved vaccines or antivirals against ZIKV infection. Taking into account that naphthoquinones have shown promising antiviral activity, the aim of this study was to describe the screening of two bis-naphthoquinones series against ZIKV. Twenty seven compounds were evaluated against ZIKV using Vero cells. The findings showed that among the compounds analyzed four were promising. Compound 3,3’-((2-nitrophenyl)methylene)bis(2-hydroxynaphthalene-1,4-dione) containing the nitro group at the ortho position showed the best selectivity index, followed by compound 3,3’-(4-chlorophenylmethylene)bis(naphthalene-1,2,4-triyl triacetate) with the chlorophenylmethylene radical. These results demonstrate that these bis-naphthoquinones are largely effective in inhibiting the replication of ZIKV.
DOI: 10.6084/m9.figshare.9599219.v1
title: Elite and legitimation at the Vale do Paraíba Law School

description: Abstract: This work aims to discuss the creation of the Faculty of Law in the Vale do Paraíba in 1954, in the city of São José dos Campos. Through testimony from people who lived in this period and newspaper publications, it was possible to conclude that the Faculty was created as a consequence of the will of the local elite to create a private educational institution that would improve the image of the city and the local actors.
DOI: 10.6084/m9.figshare.9599204
title: Solar drying of cowpea bean combined with drying in a heat accumulator dryer

description: ABSTRACT As solar radiation is abundant in Brazil during most of the year and this source of energy is renewable and non-polluting par excellence, solar drying of agricultural products is a promising methodology. The objective of this study was to dry cowpea [Vigna unguiculata (L.) Walp.] bean grains using solar energy in different exposure times, adjusting the mathematical models and calculation of the effective diffusivity. Drying was performed during the day with samples exposed to the sun; during the night, half of the samples were put to dry in a heat accumulator dryer for nighttime drying and the other half was left on a laboratory bench as control. Cowpea bean grains had initial and final moisture contents of 65.42 and 6.73% d.b. (after drying in the heat accumulator dryer), respectively. The models Approximation of Diffusion, Page, Verma, Logarithmic and Two Terms were fitted to the drying kinetics and all of them fitted well to the experimental data, with coefficients of determination (R2) higher than 0.98, mean square deviations (MSD) less than 0.01 and chi-square (χ2) values lower than 0.0001. The effective diffusivity values were of the order of 10-11 m2 s-1 for the cowpea bean samples. The heat accumulator dryer was effective as a complement to the drying by exposure to the sun, maintaining a suitable temperature for nighttime drying.
DOI: 10.6084/m9.figshare.9599207.v1
title: Fetal, neonatal, and post-neonatal mortality in the 2015 Pelotas (Brazil) birth cohort and associated factors

description: This study aimed to describe fetal, neonatal, and post-neonatal mortality and associated factors in participants of the 2015 Pelotas (Brazil) birth cohort. The child mortality sub-study followed up all deaths in the first year of life. Data were collected on intrauterine fetal deaths (weight ≥ 500g and/or gestational age ≥ 20 weeks), neonatal deaths (&lt; 28 days of life), and post-neonatal deaths (from 28 days to the end of the first year of life). Descriptive analyses using the Pearson chi-square test and a multinomial logistic regression to estimate the risk of fetal, neonatal, and post-neonatal deaths compared to live infants in the cohort (reference group) were performed. Data from 4,329 eligible births were collected, of which 54 died during the fetal period. Of the 4,275 eligible live births, 59 died in the first year of life. An association between fetal, neonatal, and post-neonatal deaths (OR = 15.60, 7.63, and 5.51 respectively) was found, as well as less than six prenatal consultations. Compared to live infants, fetal deaths were more likely to occur in non-white mothers, and neonatal deaths were 14.09 times more likely to occur in a preterm gestational age (&lt; 37 weeks). Compared to live infants, infants that were born in a C-section delivery had 3.71 increased odds of post-neonatal death. Additionally, neonatal deaths were 102.37 times more likely to have a low Apgar score on the fifth minute after birth. These findings show the need for early interventions during pregnancy, ensuring access to adequate prenatal care.
DOI: 10.6084/m9.figshare.9599210.v1
title: Inhibition of Zika Virus Replication by Synthetic Bis-Naphthoquinones

description: Zika virus (ZIKV) is a mosquito-borne pathogen which is a current global public health concern. There are currently no approved vaccines or antivirals against ZIKV infection. Taking into account that naphthoquinones have shown promising antiviral activity, the aim of this study was to describe the screening of two bis-naphthoquinones series against ZIKV. Twenty seven compounds were evaluated against ZIKV using Vero cells. The findings showed that among the compounds analyzed four were promising. Compound 3,3’-((2-nitrophenyl)methylene)bis(2-hydroxynaphthalene-1,4-dione) containing the nitro group at the ortho position showed the best selectivity index, followed by compound 3,3’-(4-chlorophenylmethylene)bis(naphthalene-1,2,4-triyl triacetate) with the chlorophenylmethylene radical. These results demonstrate that these bis-naphthoquinones are largely effective in inhibiting the replication of ZIKV.
DOI: 10.6084/m9.figshare.9599213.v1
title: Chemical Composition and Anti-Inflammatory Activity of the Decoction from Leaves of a Cultivated Specimen of Myracrodruon urundeuva

description: Myracrodruon urundeuva (Anacardiaceae) is the scientific designation of “aroeira-do-sertão”, a tree well dispersed at the northeastern Brazil. The medicinal use of this plant is widespread throughout the rural population and the inner trunk bark decoction is used to treat cutaneous affections, urinary and respiratory diseases, and gynecological problems. “Aroeira-do-sertão” has been included in the list of native species under extinction threat. In order to find a sustainable source of the plant, seedlings have been cultivated. The purpose of this work was to investigate the chemical composition of the decoction from leaves of cultivated plants (aqueous extract from Myracrodruon urundeuva (AEMU)) and its anti-inflammatory activity on human neutrophils. The addition of AEMU on cells suspension inhibited significantly its activation/degranulation induced by phorbol myristate acetate. AEMU since at 50 µg mL-1 showed better pattern of inhibitions when related to indomethacin, non-selective cyclooxygenase inhibitor used as reference anti-inflammatory. The decoction fractionation was performed by high-speed counter-current chromatography (HSCCC) and semi-preparative high-performance liquid chromatography (HPLC) using a phenyl column as the stationary phase, allowing the isolation of 24 compounds. These results showed how the AEMU is rich in bioactive metabolites, which probably contribute for the anti-inflammatory effects of this plant extract, modulating the degranulation of human neutrophils, one of the pro-inflammatory mechanism of these cells.
DOI: 10.6084/m9.figshare.9599201
title: Water relations in parsley plants cultivated in brackish nutrient solutions of different cationic natures

description: ABSTRACT The analysis of plant response to the cationic variability of the waters, in addition to the osmotic component, is indispensable in the context of salt stress. Thus, between October 2017 and February 2018, in Recife, PE, Brazil (8° 1’ 7” S and 34° 56’ 53” W, and altitude of 6.5 m), the present study was carried out to evaluate the water relations of parsley plants (Petroselinum crispum), cv. Graúda Portuguesa, cultivated in brackish nutrient solutions (electrical conductivities of 1.7, 2.7, 3.7, 4.7, 5.7 and 6.7 dS m-1) prepared in waters with different cationic natures (NaCl, CaCl2, KCl and MgCl2). The experimental design was completely randomized, in a 6 x 4 factorial scheme, with five repetitions, and five plants per plot. Two experiments were conducted sequentially under this statistical design; in the first, the evapotranspired depth was replaced with supply water (0.12 dS m-1) and in the second, with the respective brackish water. The increment in nutrient solution salinity influences the fresh and dry biomass and the percentages of total, shoot and root dry masses, and this increment led to different behavior in parsley physiology under the different cationic natures of the water, being less harmful with the use of supply water to replace the evapotranspired depth and with CaCl2 water with electrical conductivity above 5.7 dS m-1, in the replacement with brackish water.
DOI: 10.6084/m9.figshare.9599198
title: STRUCTURAL PROPERTIES OF SOIL IN MAIZE AND FORAGE GRASS INTERCROPPING UNDER NO-TILLAGE IN THE BRAZILIAN CERRADO

description: ABSTRACT Integration of forage grasses with grain crops, such as maize, allows maintaining soil cover. The objective of this study was to evaluate the tensile strength, friability, and stability of soil aggregates in the maize and forage grass intercropping under no-tillage system. The study used a completely randomized block design with seven treatments and three replications. Undisturbed soil samples were collected in two seasons (2015 and 2016) at 0–0.10 m and 0.10–0.20 m soil depth. The following properties of soil aggregates were measured: tensile strength (TS), friability (F), gravimetric moisture (GM), weighted mean diameter (WMD), geometric mean diameter (GMD), and aggregate stability index (ASI). The intercropping of maize with Urochloa ruziziensis presented higher WMD and GMD at 0.10–0.20 m soil depth. Moreover, TS at 0.10–0.20 m soil depth was lower in maize without intercropping. The effects of the intercropping system on soil aggregates were better detected by aggregate stability than by TS or F. The intercropping of maize and U. ruziziensis improved soil aggregation to a higher extent than those systems with other forage grasses.
DOI: 10.6084/m9.figshare.9599204.v1
title: Solar drying of cowpea bean combined with drying in a heat accumulator dryer

description: ABSTRACT As solar radiation is abundant in Brazil during most of the year and this source of energy is renewable and non-polluting par excellence, solar drying of agricultural products is a promising methodology. The objective of this study was to dry cowpea [Vigna unguiculata (L.) Walp.] bean grains using solar energy in different exposure times, adjusting the mathematical models and calculation of the effective diffusivity. Drying was performed during the day with samples exposed to the sun; during the night, half of the samples were put to dry in a heat accumulator dryer for nighttime drying and the other half was left on a laboratory bench as control. Cowpea bean grains had initial and final moisture contents of 65.42 and 6.73% d.b. (after drying in the heat accumulator dryer), respectively. The models Approximation of Diffusion, Page, Verma, Logarithmic and Two Terms were fitted to the drying kinetics and all of them fitted well to the experimental data, with coefficients of determination (R2) higher than 0.98, mean square deviations (MSD) less than 0.01 and chi-square (χ2) values lower than 0.0001. The effective diffusivity values were of the order of 10-11 m2 s-1 for the cowpea bean samples. The heat accumulator dryer was effective as a complement to the drying by exposure to the sun, maintaining a suitable temperature for nighttime drying.
DOI: 10.6084/m9.figshare.9599195
title: Do-it-yourself 3D digitizing tools in preservation of cultural heritage

description: Abstract: With the purpose of making 3D digitization more accessible in museums, this study looks into adequate solutions for a low-cost scenario. Based on a do-it-yourself perspective, photogrammetry and laser scanning techniques were experimented on three artefacts from the Júlio de Castilhos Museum, Porto Alegre, Brazil. Both techniques have shown great results, but the one based on photogrammetry presented more advantages, such as a smaller learning curve.
DOI: 10.6084/m9.figshare.9599198.v1
title: STRUCTURAL PROPERTIES OF SOIL IN MAIZE AND FORAGE GRASS INTERCROPPING UNDER NO-TILLAGE IN THE BRAZILIAN CERRADO

description: ABSTRACT Integration of forage grasses with grain crops, such as maize, allows maintaining soil cover. The objective of this study was to evaluate the tensile strength, friability, and stability of soil aggregates in the maize and forage grass intercropping under no-tillage system. The study used a completely randomized block design with seven treatments and three replications. Undisturbed soil samples were collected in two seasons (2015 and 2016) at 0–0.10 m and 0.10–0.20 m soil depth. The following properties of soil aggregates were measured: tensile strength (TS), friability (F), gravimetric moisture (GM), weighted mean diameter (WMD), geometric mean diameter (GMD), and aggregate stability index (ASI). The intercropping of maize with Urochloa ruziziensis presented higher WMD and GMD at 0.10–0.20 m soil depth. Moreover, TS at 0.10–0.20 m soil depth was lower in maize without intercropping. The effects of the intercropping system on soil aggregates were better detected by aggregate stability than by TS or F. The intercropping of maize and U. ruziziensis improved soil aggregation to a higher extent than those systems with other forage grasses.
DOI: 10.6084/m9.figshare.9599189
title: Analytical Hierarchical Process (AHP) in the GIS Environment: issues and applications for decision making using spatial criteria

description: Abstract: This is a bibliographical survey about the application of the AHP method in combination with Geographic Information Systems (GIS). The review was carried out with articles published in the last 10 years related to the use of this method, under a qualitative approach. From the analysis of the 12 scientific categories described in this article, it was possible to point out the AHP method used with GIS as an effective tool for multicriteria analysis in different scenarios.
DOI: 10.6084/m9.figshare.9599186
title: Guidelines for planning a selective demolition on buildings

description: Abstract: The objective of this article is to develop a set of guidelines that allow to improve the planning of the demolition activities and to promote more sustainable practices in the construction site. The empirical research was carried out by the application of three case studies, developing a diagnosis of the operation of the activities of the companies practicing the selective demolition in small buildings, through interviews, monitoring the demolitions and the resale of the materials. Thus, it was possible to verify the existence of markets for recycled materials and components that promote local development.
DOI: 10.6084/m9.figshare.9599189.v1
title: Analytical Hierarchical Process (AHP) in the GIS Environment: issues and applications for decision making using spatial criteria

description: Abstract: This is a bibliographical survey about the application of the AHP method in combination with Geographic Information Systems (GIS). The review was carried out with articles published in the last 10 years related to the use of this method, under a qualitative approach. From the analysis of the 12 scientific categories described in this article, it was possible to point out the AHP method used with GIS as an effective tool for multicriteria analysis in different scenarios.
DOI: 10.6084/m9.figshare.9599195.v1
title: Do-it-yourself 3D digitizing tools in preservation of cultural heritage

description: Abstract: With the purpose of making 3D digitization more accessible in museums, this study looks into adequate solutions for a low-cost scenario. Based on a do-it-yourself perspective, photogrammetry and laser scanning techniques were experimented on three artefacts from the Júlio de Castilhos Museum, Porto Alegre, Brazil. Both techniques have shown great results, but the one based on photogrammetry presented more advantages, such as a smaller learning curve.
DOI: 10.6084/m9.figshare.9599177
title: Digital radiography as an alternative method in the evaluation of bone density in uremic rats

description: ABSTRACT Introduction: Digital radiography (DRx) may provide a suitable alternative to investigate mineral and bone disorder (MBD) and loss of bone density (BD) in rodent models of chronic kidney disease (CKD). The objective of this study was to use DRx to evaluate BD in CKD rats, and to evaluate the correlation between DRx findings and serum MBD markers and bone histomorphometry. Methods: Uremia was induced by feeding Wistar rats an adenine-enriched diet (0.75% for 4 weeks/0.10% for 3 weeks); outcomes were compared to a control group at experimental weeks 3, 4, and 7. The following biochemical markers were measured: creatinine clearance (CrC), phosphate (P), calcium (Ca), fractional excretion of P (FeP), alkaline phosphatase (ALP), fibroblast growth factor-23 (FGF-23), and parathyroid hormone (PTH). DRx imaging was performed and histomorphometry analysis was conducted using the left femur. Results: As expected, at week 7, uremic rats presented with reduced CrC and higher levels of P, FeP, and ALP compared to controls. DRx confirmed the lower BD in uremic animals (0.57±0.07 vs. 0.68 ± 0.06 a.u.; p = 0.016) compared to controls at the end of week 7, when MBD was more prominent. A severe form of high-turnover bone disease accompanied these biochemical changes. BD measured on DRx correlated to P (r=-0.81; p = 0.002), ALP (r = -0.69, p = 0.01), PTH (r = -0.83, p = 0.01), OS/BS (r = -0.70; p = 0.02), and ObS/BS (r = -0.70; p = 0.02). Conclusion: BD quantified by DRx was associated with the typical complications of MBD in CKD and showed to be viable in the evaluation of bone alterations in CKD.
DOI: 10.6084/m9.figshare.9599180
title: Toxoplasma gondii in cetaceans of Brazil: a histopathological and immunohistochemical survey

description: Abstract Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. In cetaceans, T. gondii infection is a significant cause of morbidity and mortality. Despite the worldwide range and broad cetacean host record of T. gondii infection, there is limited information on toxoplasmosis in cetaceans from the Southern hemisphere. We investigated the occurrence of T. gondii by histopathology and immunohistochemistry in tissue samples of 185 animals comprising 20 different cetacean species from Brazil. Three out of 185 (1.6%) animals presented T. gondii-associated lesions: a captive killer whale Orcinus orca, a free-ranging common bottlenose dolphin Tursiops truncatus and a free-ranging Guiana dolphin Sotalia guianensis. The main lesions observed in these animals were necrotizing hepatitis, adrenalitis and lymphadenitis associated with protozoal cysts or extracellular tachyzoites presenting immunolabeling with anti-T. gondii antibodies. This study widens the spectrum of species and the geographic range of this agent in Brazil, and provides the first reports of T. gondii infection in a captive killer whale and in a free-ranging common bottlenose dolphin in South America.
DOI: 10.6084/m9.figshare.9599186.v1
title: Guidelines for planning a selective demolition on buildings

description: Abstract: The objective of this article is to develop a set of guidelines that allow to improve the planning of the demolition activities and to promote more sustainable practices in the construction site. The empirical research was carried out by the application of three case studies, developing a diagnosis of the operation of the activities of the companies practicing the selective demolition in small buildings, through interviews, monitoring the demolitions and the resale of the materials. Thus, it was possible to verify the existence of markets for recycled materials and components that promote local development.
DOI: 10.6084/m9.figshare.9599177.v1
title: Digital radiography as an alternative method in the evaluation of bone density in uremic rats

description: ABSTRACT Introduction: Digital radiography (DRx) may provide a suitable alternative to investigate mineral and bone disorder (MBD) and loss of bone density (BD) in rodent models of chronic kidney disease (CKD). The objective of this study was to use DRx to evaluate BD in CKD rats, and to evaluate the correlation between DRx findings and serum MBD markers and bone histomorphometry. Methods: Uremia was induced by feeding Wistar rats an adenine-enriched diet (0.75% for 4 weeks/0.10% for 3 weeks); outcomes were compared to a control group at experimental weeks 3, 4, and 7. The following biochemical markers were measured: creatinine clearance (CrC), phosphate (P), calcium (Ca), fractional excretion of P (FeP), alkaline phosphatase (ALP), fibroblast growth factor-23 (FGF-23), and parathyroid hormone (PTH). DRx imaging was performed and histomorphometry analysis was conducted using the left femur. Results: As expected, at week 7, uremic rats presented with reduced CrC and higher levels of P, FeP, and ALP compared to controls. DRx confirmed the lower BD in uremic animals (0.57±0.07 vs. 0.68 ± 0.06 a.u.; p = 0.016) compared to controls at the end of week 7, when MBD was more prominent. A severe form of high-turnover bone disease accompanied these biochemical changes. BD measured on DRx correlated to P (r=-0.81; p = 0.002), ALP (r = -0.69, p = 0.01), PTH (r = -0.83, p = 0.01), OS/BS (r = -0.70; p = 0.02), and ObS/BS (r = -0.70; p = 0.02). Conclusion: BD quantified by DRx was associated with the typical complications of MBD in CKD and showed to be viable in the evaluation of bone alterations in CKD.
DOI: 10.6084/m9.figshare.9599180.v1
title: Toxoplasma gondii in cetaceans of Brazil: a histopathological and immunohistochemical survey

description: Abstract Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. In cetaceans, T. gondii infection is a significant cause of morbidity and mortality. Despite the worldwide range and broad cetacean host record of T. gondii infection, there is limited information on toxoplasmosis in cetaceans from the Southern hemisphere. We investigated the occurrence of T. gondii by histopathology and immunohistochemistry in tissue samples of 185 animals comprising 20 different cetacean species from Brazil. Three out of 185 (1.6%) animals presented T. gondii-associated lesions: a captive killer whale Orcinus orca, a free-ranging common bottlenose dolphin Tursiops truncatus and a free-ranging Guiana dolphin Sotalia guianensis. The main lesions observed in these animals were necrotizing hepatitis, adrenalitis and lymphadenitis associated with protozoal cysts or extracellular tachyzoites presenting immunolabeling with anti-T. gondii antibodies. This study widens the spectrum of species and the geographic range of this agent in Brazil, and provides the first reports of T. gondii infection in a captive killer whale and in a free-ranging common bottlenose dolphin in South America.