cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4763350
title: Supplementary Material for: Multiple Drug Hypersensitivity

description: Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS). Subsequent symptoms due to another drug often appear in the following weeks, overlapping with the first DHR, or months to years later after resolution of the initial presentation. The second DHR includes exanthema, erythroderma, DRESS, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hepatitis, and agranulocytosis. The eliciting drugs can be identified by positive skin or in vitro tests. The drugs involved in starting the MDH are the same as for DRESS, and they are usually given in rather high doses. Fixed drug combination therapies like sulfamethoxazole/trimethoprim or piperacillin/tazobactam are frequently involved in MDH, and 30-40% of patients with severe DHR to combination therapy show T-cell reactions to both components. The drug-induced T-cell stimulation appears to be due to the p-i mechanism. Importantly, a permanent T-cell activation characterized by PD-1+/CD38+ expression on CD4+/CD25<sup>low</sup> T cells can be found in the circulation of patients with MDH for many years. In conclusion, MDH is a drug-elicited syndrome characterized by a long-lasting hyperresponsiveness to multiple, structurally unrelated drugs with clinically diverse symptoms.
DOI: 10.6084/m9.figshare.4763326
title: Supplementary Material for: Antimicrobial Susceptibility among European Gram-Negative and Gram-Positive Isolates Collected as Part of the Tigecycline Evaluation and Surveillance Trial (2004-2014)

description: <i>Background:</i> European centers (n = 226) involved in the Tigecycline Evaluation and Surveillance Trial (TEST, 2004-2014) submitted data and bacterial isolates. <i>Methods:</i>Minimal inhibitory concentrations and susceptibility were determined using Clinical and Laboratory Standards Institute methods and European Committee on Antimicrobial Susceptibility Testing breakpoints. <i>Results:</i> The rates of the following resistant pathogens increased from 2004 to 2014: extended-spectrum β-lactamase (ESBL)-positive <i>Escherichia coli</i> (from 8.9 to 16.9%), multidrug-resistant <i>Acinetobacter baumannii</i> complex (from 15.4 to 48.5%), and ESBL-positive <i>Klebsiella pneumoniae</i>(from 17.2 to 23.7%). The rate of methicillin-resistant <i>Staphylococcus aureus</i> was 27.5% in 2004 and 28.9% in 2014. Resistance to the carbapenems (imipenem and meropenem) was 37.4 and 14.5% for <i>A. baumannii</i> complex and <i>Pseudomonas aeruginosa</i>, respectively. Carbapenem resistance was ≤4.3% among the Enterobacteriaceae and 0.2% against <i>Streptococcus pneumoniae.</i> The resistance to tigecycline ranged between 7.4% against ESBL-producing <i>K. pneumoniae </i>and 0.0% against <i>S. aureus.</i><i>Conclusions:</i> The carbapenems and tigecycline were active against Enterobacteriaceae. Agents with activity against <i>A. baumannii</i> complex and <i>P. aeruginosa</i> are limited. The carbapenems, tigecycline, linezolid, and vancomycin were active against Gram-positive organisms.
DOI: 10.6084/m9.figshare.4763335
title: Anatomy Textbook Analysis

description: Two CSV files:1. Coding of all images2. Coding of narrative images only
DOI: 10.6084/m9.figshare.4763323
title: Rubric

description: There are two categories of criteria in the rubrics:• Specific criteria: attributes from Cr1 to Cr10, they refer to specific criteria of the work. • Transversal criteria: attributes from Cr11 to Cr17, they refer to generic criteria of the work: coherence, correct use of wiki-format, etc. Scalability<br>
DOI: 10.6084/m9.figshare.4763302
title: DataNetwork.xlsx

description: Network and environmental data for BIOCOM global dataset<br>
DOI: 10.6084/m9.figshare.4763314
title: Table - Final assessment.pdf

description: Students' performance in the wiki assignment.
DOI: 10.6084/m9.figshare.4763323.v1
title: Rubric

description: There are two categories of criteria in the rubrics:• Specific criteria: attributes from Cr1 to Cr10, they refer to specific criteria of the work. • Transversal criteria: attributes from Cr11 to Cr17, they refer to generic criteria of the work: coherence, correct use of wiki-format, etc. Scalability<br>
DOI: 10.6084/m9.figshare.4763299
title: Amphibians_contribute_biodiversity.xlsx

description: This is the regional amphibian species pool in Emei Mountain, with 11 functional traits for each species.<br>
DOI: 10.6084/m9.figshare.4763314.v1
title: Table - Final assessment.pdf

description: Students' performance in the wiki assignment.
DOI: 10.6084/m9.figshare.4763296
title: IMPACT OF A HYBRID TGFU-SPORT EDUCATION UNIT ON STUDENT MOTIVATION IN PHYSICAL EDUCATION.sav

description: The purpose of the current study was to investigate the effect a hybrid TGfU/SE unit, in comparison to direct instruction, on students’ perceptions of various aspects of their motivation to engage in physical education (autonomous motivation, basic psychological needs, enjoyment and intention to be physically active). A crossover design was utilized, using the technique of counterbalancing. Participants were 55 students. The intervention was conducted over a total of 16 lessons. The hybrid unit was designed according to the characteristics of SE by using seasons, roles, persistent teams, etc. Learning tasks set by the teacher during individual lessons, however, were designed according to the pedagogical principles of TGfU. Results showed that regardless of the order of intervention, the two groups showed significant improvements in autonomy, competence and enjoyment when they were taught using the hybrid model. These results demonstrate that it is possible to design varied learning situations in which affiliation, leadership and trust are fostered, while tasks are adapted to the characteristics of the students. All this can cause greater autonomous motivation, and consequently, perceived competence in the student, a positive image of the sport to practice, and therefore greater enjoyment and to be physically active.
DOI: 10.6084/m9.figshare.4763299.v1
title: Amphibians_contribute_biodiversity.xlsx

description: This is the regional amphibian species pool in Emei Mountain, with 11 functional traits for each species.<br>
DOI: 10.6084/m9.figshare.4763287.v2
title: pulmonary nodules data

description: Four types pulmonary nodules
DOI: 10.6084/m9.figshare.4763287.v1
title: pulmonary nodules data

description: Four types pulmonary nodules
DOI: 10.6084/m9.figshare.4762642
title: Data of Fig 5

description: Results of fed-batch fermentation process of P. pastoris X33::hgmcsf and S. cerevisiae BY4742/pYES2-hgmcsf
DOI: 10.6084/m9.figshare.4762636
title: Data of Fig 7

description: Results of bioactivity analysis of purified hGM-CSF derived from P. pastoris X33::hgmcsf and S. cerevisiae BY4742/pYES2-hgmcsf
DOI: 10.6084/m9.figshare.4762642.v1
title: Data of Fig 5

description: Results of fed-batch fermentation process of P. pastoris X33::hgmcsf and S. cerevisiae BY4742/pYES2-hgmcsf
DOI: 10.6084/m9.figshare.4762492
title: AFM white

description: white noise
DOI: 10.6084/m9.figshare.4762495
title: Reducing workplace burnout through exercise

description: Objectives. The global burden of burnout cost is in excess of $300 billion annually. Locally, just under half of working Australians experience high levels of occupational burnout. Consequently, burnout interventions are paramount to organisational productivity. Exercise has the potential to provide a multilevel and cost effective burnout intervention. The current study aims to extend the literature by comparing cardiovascular with resistance exercise to assess their relative effectiveness against well-being, perceived stress, and burnout. Design. Participants were 49 (36 females and 13 males) previously inactive volunteers ranging in age from 19 to 68 that completed a four week exercise program of either cardiovascular, resistance, or no exercise (control). Randomised control trial design was employed. Method. Participants were measured against the Subjective Exercise Experience Scale, the Perceived Stress Scale, and the Maslach Burnout Inventory. Results. After four weeks of exercise participants had greater positive well-being and personal accomplishment, and concomitantly less psychological distress, perceived stress, and emotional exhaustion. Cardiovascular exercise was found to increase well-being and decrease psychological distress, perceived stress, and emotional exhaustion. Resistance training was noticeably effective in increasing well-being and personal accomplishment and to reduce perceived stress. The present findings revealed large effect sizes suggesting that exercise may be an effective treatment for burnout. However, given a small sample size further research needs to be conducted. Conclusion. Exercise has potential to be an effective burnout intervention. Different types of exercise may assist employees in different ways. Organisations wishing to proactively reduce burnout can do so by encouraging their employees to access regular exercise programs.
DOI: 10.6084/m9.figshare.4762636.v1
title: Data of Fig 7

description: Results of bioactivity analysis of purified hGM-CSF derived from P. pastoris X33::hgmcsf and S. cerevisiae BY4742/pYES2-hgmcsf
DOI: 10.6084/m9.figshare.4762483
title: AFM rr

description: rr noise
DOI: 10.6084/m9.figshare.4762480
title: AFM no noise

description: AFM no noise
DOI: 10.6084/m9.figshare.4762468
title: kuramoto noise 2

description: noise amplitude 2
DOI: 10.6084/m9.figshare.4762474
title: kuramoto noise 4

description: noise amplitude 4
DOI: 10.6084/m9.figshare.4762477
title: AFM gauss

description: gaussian noise
DOI: 10.6084/m9.figshare.4762495.v1
title: Reducing workplace burnout through exercise

description: Objectives. The global burden of burnout cost is in excess of $300 billion annually. Locally, just under half of working Australians experience high levels of occupational burnout. Consequently, burnout interventions are paramount to organisational productivity. Exercise has the potential to provide a multilevel and cost effective burnout intervention. The current study aims to extend the literature by comparing cardiovascular with resistance exercise to assess their relative effectiveness against well-being, perceived stress, and burnout. Design. Participants were 49 (36 females and 13 males) previously inactive volunteers ranging in age from 19 to 68 that completed a four week exercise program of either cardiovascular, resistance, or no exercise (control). Randomised control trial design was employed. Method. Participants were measured against the Subjective Exercise Experience Scale, the Perceived Stress Scale, and the Maslach Burnout Inventory. Results. After four weeks of exercise participants had greater positive well-being and personal accomplishment, and concomitantly less psychological distress, perceived stress, and emotional exhaustion. Cardiovascular exercise was found to increase well-being and decrease psychological distress, perceived stress, and emotional exhaustion. Resistance training was noticeably effective in increasing well-being and personal accomplishment and to reduce perceived stress. The present findings revealed large effect sizes suggesting that exercise may be an effective treatment for burnout. However, given a small sample size further research needs to be conducted. Conclusion. Exercise has potential to be an effective burnout intervention. Different types of exercise may assist employees in different ways. Organisations wishing to proactively reduce burnout can do so by encouraging their employees to access regular exercise programs.
DOI: 10.6084/m9.figshare.4762471
title: Kuramoto noise 3

description: noise amplitude 3
DOI: 10.6084/m9.figshare.4762465
title: Kuramoto noise 1

description: noise amplitude 1
DOI: 10.6084/m9.figshare.4762429
title: Kuramoto no noise

description: samples of the data obtained with the Atrial Fibrillation model (AFM) and the Kuramoto model
DOI: 10.6084/m9.figshare.4762465.v1
title: Kuramoto noise 1

description: noise amplitude 1
DOI: 10.6084/m9.figshare.4762426
title: Arsenic mineralogy and distribution at the historic Alexander gold mine, Reefton goldfield, New Zealand

description: A processing complex consisting of two sites adjacent to the Alexander River was developed prior to the 1950s for the Alexander orogenic gold mine on the West Coast of New Zealand. The mineralogy of the As has been defined at both sites, in order to evaluate potential environmental toxicity. Arsenic levels are highest (&gt; 35 wt%) where the ore had been roasted, converting sulfides to arsenolite (As(III)<sub>2</sub>O<sub>3</sub>), which is soluble in the wet environment. High As levels elsewhere on the processing complex occur as secondary As(V)–Fe(III)–Ca minerals, including pharmacolite and yukonite, and As-bearing hematite. Sulfide concentrates stored on-site have oxidised to semi-cemented amorphous hydrous Fe(III) oxides and arsenates, resulting in localised acid generation (pH as low as 3) and As levels up to 4 wt%. Despite high levels of As in the processing residues and the wet climate, negligible As is being mobilised into stream waters, and the dissolved As level is
DOI: 10.6084/m9.figshare.4762495.v2
title: Reducing workplace burnout through exercise

description: Objectives. The global burden of burnout cost is in excess of $300 billion annually. Locally, just under half of working Australians experience high levels of occupational burnout. Consequently, burnout interventions are paramount to organisational productivity. Exercise has the potential to provide a multilevel and cost effective burnout intervention. The current study aims to extend the literature by comparing cardiovascular with resistance exercise to assess their relative effectiveness against well-being, perceived stress, and burnout. Design. Participants were 49 (36 females and 13 males) previously inactive volunteers ranging in age from 19 to 68 that completed a four week exercise program of either cardiovascular, resistance, or no exercise (control). Randomised control trial design was employed. Method. Participants were measured against the Subjective Exercise Experience Scale, the Perceived Stress Scale, and the Maslach Burnout Inventory. Results. After four weeks of exercise participants had greater positive well-being and personal accomplishment, and concomitantly less psychological distress, perceived stress, and emotional exhaustion. Cardiovascular exercise was found to increase well-being and decrease psychological distress, perceived stress, and emotional exhaustion. Resistance training was noticeably effective in increasing well-being and personal accomplishment and to reduce perceived stress. The present findings revealed large effect sizes suggesting that exercise may be an effective treatment for burnout. However, given a small sample size further research needs to be conducted. Conclusion. Exercise has potential to be an effective burnout intervention. Different types of exercise may assist employees in different ways. Organisations wishing to proactively reduce burnout can do so by encouraging their employees to access regular exercise programs.
DOI: 10.6084/m9.figshare.4762426.v1
title: Arsenic mineralogy and distribution at the historic Alexander gold mine, Reefton goldfield, New Zealand

description: A processing complex consisting of two sites adjacent to the Alexander River was developed prior to the 1950s for the Alexander orogenic gold mine on the West Coast of New Zealand. The mineralogy of the As has been defined at both sites, in order to evaluate potential environmental toxicity. Arsenic levels are highest (&gt; 35 wt%) where the ore had been roasted, converting sulfides to arsenolite (As(III)<sub>2</sub>O<sub>3</sub>), which is soluble in the wet environment. High As levels elsewhere on the processing complex occur as secondary As(V)–Fe(III)–Ca minerals, including pharmacolite and yukonite, and As-bearing hematite. Sulfide concentrates stored on-site have oxidised to semi-cemented amorphous hydrous Fe(III) oxides and arsenates, resulting in localised acid generation (pH as low as 3) and As levels up to 4 wt%. Despite high levels of As in the processing residues and the wet climate, negligible As is being mobilised into stream waters, and the dissolved As level is
DOI: 10.6084/m9.figshare.4762495.v3
title: Reducing workplace burnout through exercise

description: Objectives. The global burden of burnout cost is in excess of $300 billion annually. Locally, just under half of working Australians experience high levels of occupational burnout. Consequently, burnout interventions are paramount to organisational productivity. Exercise has the potential to provide a multilevel and cost effective burnout intervention. The current study aims to extend the literature by comparing cardiovascular with resistance exercise to assess their relative effectiveness against well-being, perceived stress, and burnout. Design. Participants were 49 (36 females and 13 males) previously inactive volunteers ranging in age from 19 to 68 that completed a four week exercise program of either cardiovascular, resistance, or no exercise (control). Randomised control trial design was employed. Method. Participants were measured against the Subjective Exercise Experience Scale, the Perceived Stress Scale, and the Maslach Burnout Inventory. Results. After four weeks of exercise participants had greater positive well-being and personal accomplishment, and concomitantly less psychological distress, perceived stress, and emotional exhaustion. Cardiovascular exercise was found to increase well-being and decrease psychological distress, perceived stress, and emotional exhaustion. Resistance training was noticeably effective in increasing well-being and personal accomplishment and to reduce perceived stress. The present findings revealed large effect sizes suggesting that exercise may be an effective treatment for burnout. However, given a small sample size further research needs to be conducted. Conclusion. Exercise has potential to be an effective burnout intervention. Different types of exercise may assist employees in different ways. Organisations wishing to proactively reduce burnout can do so by encouraging their employees to access regular exercise programs.
DOI: 10.6084/m9.figshare.4762225
title: MALDI mass spectrometry reveals that cumulus cells modulate the lipid profile of <i>in vitro-</i>matured bovine oocytes

description: The influence of cumulus cells (CC) on the lipid profile of bovine oocytes matured in two different lipid sources was investigated. Cumulus-oocyte complexes (COC) or denuded oocytes (DO) were matured in tissue culture medium (TCM) supplemented with fetal bovine serum (FBS) or serum substitute supplement (SSS). Lipid profiles of TCM, serum supplements, immature CC and oocyte (IO), and <i>in vitro</i>-matured oocytes from COC and DO were then analyzed by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) and submitted to partial least squares-discriminant analysis (PLS-DA). The developmental competence of such oocytes was also assessed. Differences in lipid composition were observed between two types of sera and distinctly influenced the lipid profile of CC. As revealed by PLS-DA, the abundance of specific ions corresponding to triacylglycerols (TAG) or phospholipids (PL) were higher in COC compared to DO both supplemented with FBS or SSS and to some extent affected the subsequent DO <i>in vitro</i> embryo development. DO exposed to SSS had however a marked diminished ability to develop to the blastocyst stage. These results indicate a modulation by CC of the oocyte TAG and PL profiles associated with a specific cell response to the serum supplement used for <i>in vitro</i> maturation.
DOI: 10.6084/m9.figshare.4762225.v1
title: MALDI mass spectrometry reveals that cumulus cells modulate the lipid profile of <i>in vitro-</i>matured bovine oocytes

description: The influence of cumulus cells (CC) on the lipid profile of bovine oocytes matured in two different lipid sources was investigated. Cumulus-oocyte complexes (COC) or denuded oocytes (DO) were matured in tissue culture medium (TCM) supplemented with fetal bovine serum (FBS) or serum substitute supplement (SSS). Lipid profiles of TCM, serum supplements, immature CC and oocyte (IO), and <i>in vitro</i>-matured oocytes from COC and DO were then analyzed by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) and submitted to partial least squares-discriminant analysis (PLS-DA). The developmental competence of such oocytes was also assessed. Differences in lipid composition were observed between two types of sera and distinctly influenced the lipid profile of CC. As revealed by PLS-DA, the abundance of specific ions corresponding to triacylglycerols (TAG) or phospholipids (PL) were higher in COC compared to DO both supplemented with FBS or SSS and to some extent affected the subsequent DO <i>in vitro</i> embryo development. DO exposed to SSS had however a marked diminished ability to develop to the blastocyst stage. These results indicate a modulation by CC of the oocyte TAG and PL profiles associated with a specific cell response to the serum supplement used for <i>in vitro</i> maturation.
DOI: 10.6084/m9.figshare.4762138
title: Clostridium difficile toxin level

description: These are datasets of patients with Clostridium difficile in whom toxin levels were determined using ELISA
DOI: 10.6084/m9.figshare.4762180
title: ThrEEBoost: Thresholded Boosting for Variable Selection and Prediction via Estimating Equations

description: Most variable selection techniques for high-dimensional models are designed to be used in settings, where observations are independent and completely observed. At the same time, there is a rich literature on approaches to estimation of low-dimensional parameters in the presence of correlation, missingness, measurement error, selection bias, and other characteristics of real data. In this article, we present ThrEEBoost (<i>Thr</i>esholded <i>EEBoost</i>), a general-purpose variable selection technique which can accommodate such problem characteristics by replacing the gradient of the loss by an estimating function. ThrEEBoost generalizes the previously proposed EEBoost algorithm (Wolfson 2011) by allowing the number of regression coefficients updated at each step to be controlled by a thresholding parameter. Different thresholding parameter values yield different variable selection paths, greatly diversifying the set of models that can be explored; the optimal degree of thresholding can be chosen by cross-validation. ThrEEBoost was evaluated using simulation studies to assess the effects of different threshold values on prediction error, sensitivity, specificity, and the number of iterations to identify minimum prediction error under both sparse and nonsparse true models with correlated continuous outcomes. We show that when the true model is sparse, ThrEEBoost achieves similar prediction error to EEBoost while requiring fewer iterations to locate the set of coefficients yielding the minimum error. When the true model is less sparse, ThrEEBoost has lower prediction error than EEBoost and also finds the point yielding the minimum error more quickly. The technique is illustrated by applying it to the problem of identifying predictors of weight change in a longitudinal nutrition study. Supplementary materials are available online.
DOI: 10.6084/m9.figshare.4759354
title: data for uploading.pdf

description: these are datasets for graphs as well as blot images