cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13947617.v1
title: Supplementary Material for: The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients

description: <b><i>Background:</i></b> There are great interindividual variations in the clinical efficacy of methotrexate (MTX) treatment and patients’ genetic background seems promising in its explanation. <b><i>Objectives:</i></b> The study aimed to test whether the polymorphism of annexin A6 (ANxA6) gene, a susceptibility factor for psoriasis, was associated with the clinical response to MTX therapy. <b><i>Methods:</i></b> A total of 325 patients enrolled in the study received oral MTX treatment, of whom 310 completed the 1-year study and performed the genotype analysis. They were defined as responders (a reduction of Psoriasis Area and Severity Index [PASI] score ≥75%) and nonresponders (a reduction of PASI &lt;50%) compared to baseline after 12 weeks of short-time therapy. On 1-year treatment, they were defined as responders if they achieved PASI75 and absolute PASI ≤3, otherwise as nonresponders. The genotypes of 4 single-nucleotide polymorphisms (SNPs) in the ANxA6 gene were verified using the Sequenom platform. Potential predictors associated with the treatment outcome of MTX were assessed by binary logistic regression. <b><i>Results:</i></b> We found significant associations for the ANxA6 SNPs of rs11960458, rs960709, and rs13168551 with psoriasis severity. Patients with rs11960458 CC genotype and rs960709 GG genotype showed higher percentages of PASI75 and improvement rates of PASI at 12 weeks. And on 1-year treatment, statistical difference occurred in rs11960458 rather than other SNPs compared between responders and nonresponders that the frequency of CC genotype was higher in responders (<i>p</i> = 0.019). After adjustment for potential confounders, patients with rs11960458 TT/CT genotype (at 12 weeks: OR 0.483, 95% CI 0.245–0.951, <i>p</i> = 0.035; at 1 year: OR 0.483, 95% CI 0.280–0.833, <i>p</i> = 0.009) were significantly more likely to not respond to MTX both on the short-term and long-term treatment, while rs960709 and rs13168551 polymorphisms were only associated with the short-term efficacy of MTX (<i>p</i> = 0.018 and <i>p</i> = 0.036, respectively). <b><i>Conclusions:</i></b> The CC ge­notype of ANxA6 (rs11960458) was significantly associated with a better response when compared to those patients with the TT/CT genotype, thus being a potential predictor for the clinical efficacy of MTX.
DOI: 10.6084/m9.figshare.13948028
title: Supplementary Material for: Evaluation of Renal Fibrosis by Mapping Histology and Magnetic Resonance Imaging

description: <b><i>Background:</i></b> Renal fibrosis is a key driver of progression in chronic kidney disease (CKD). Recent advances in diagnostic imaging techniques have shown promising results for the noninvasive assessment of renal fibrosis. However, the specificity and accuracy of these techniques are controversial because they indirectly assess renal fibrosis. This limits fibrosis assessment by imaging in CKD for clinical practice. To validate magnetic resonance imaging (MRI) assessment for fibrosis, we derived representative models by mapping histology-proven renal fibrosis and imaging in CKD. <b><i>Methods:</i></b> Ninety-seven adult Chinese CKD participants with histology were studied. The kidney cortex interstitial extracellular matrix volume was calculated by the Aperio ScanScope system using Masson’s trichrome slices. The kidney cortex microcirculation was quantitatively assessed by peritubular capillary density using CD34 staining. The imaging techniques included intravoxel incoherent motion diffusion-weighted imaging and magnetic resonance elastography (MRE) imaging. Relevant analyses were performed to evaluate the correlations between MRI parameters and histology variables. Multiple linear regression models were used to describe the relationships between a response variable and other variables. The best-fit lines, which minimize the sum of squared residuals of the multiple linear regression models, were generated. <b><i>Results:</i></b> MRE values were negatively associated with the interstitial extracellular matrix volume (<i>Rho</i> = −0.397, <i>p</i> &lt; 0.001). The best mapping model of extracellular matrix volume with the MRE value and estimated glomerular filtration rate (eGFR) we obtained was as follows: Interstitial extracellular matrix volume = 218.504 – 14.651 × In(MRE) – 18.499 × In(eGFR). DWI-fraction values were positively associated with peritubular capillary density (<i>Rho</i> = 0.472, <i>p</i> &lt; 0.001). The best mapping model of peritubular capillary density with DWI-fraction value and eGFR was as follows: Peritubular capillaries density = 17.914 + 9.403 × (DWI – fraction) + 0.112 × (eGFR). <b><i>Conclusions:</i></b> The study provides histological evidence to support that MRI can effectively evaluate fibrosis in the kidney. These findings picture the graphs of the mapping model from imaging and eGFR into fibrosis, which has significant value for clinical implementation.
DOI: 10.6084/m9.figshare.13948028.v1
title: Supplementary Material for: Evaluation of Renal Fibrosis by Mapping Histology and Magnetic Resonance Imaging

description: <b><i>Background:</i></b> Renal fibrosis is a key driver of progression in chronic kidney disease (CKD). Recent advances in diagnostic imaging techniques have shown promising results for the noninvasive assessment of renal fibrosis. However, the specificity and accuracy of these techniques are controversial because they indirectly assess renal fibrosis. This limits fibrosis assessment by imaging in CKD for clinical practice. To validate magnetic resonance imaging (MRI) assessment for fibrosis, we derived representative models by mapping histology-proven renal fibrosis and imaging in CKD. <b><i>Methods:</i></b> Ninety-seven adult Chinese CKD participants with histology were studied. The kidney cortex interstitial extracellular matrix volume was calculated by the Aperio ScanScope system using Masson’s trichrome slices. The kidney cortex microcirculation was quantitatively assessed by peritubular capillary density using CD34 staining. The imaging techniques included intravoxel incoherent motion diffusion-weighted imaging and magnetic resonance elastography (MRE) imaging. Relevant analyses were performed to evaluate the correlations between MRI parameters and histology variables. Multiple linear regression models were used to describe the relationships between a response variable and other variables. The best-fit lines, which minimize the sum of squared residuals of the multiple linear regression models, were generated. <b><i>Results:</i></b> MRE values were negatively associated with the interstitial extracellular matrix volume (<i>Rho</i> = −0.397, <i>p</i> &lt; 0.001). The best mapping model of extracellular matrix volume with the MRE value and estimated glomerular filtration rate (eGFR) we obtained was as follows: Interstitial extracellular matrix volume = 218.504 – 14.651 × In(MRE) – 18.499 × In(eGFR). DWI-fraction values were positively associated with peritubular capillary density (<i>Rho</i> = 0.472, <i>p</i> &lt; 0.001). The best mapping model of peritubular capillary density with DWI-fraction value and eGFR was as follows: Peritubular capillaries density = 17.914 + 9.403 × (DWI – fraction) + 0.112 × (eGFR). <b><i>Conclusions:</i></b> The study provides histological evidence to support that MRI can effectively evaluate fibrosis in the kidney. These findings picture the graphs of the mapping model from imaging and eGFR into fibrosis, which has significant value for clinical implementation.
DOI: 10.20351/29he20010119
title: ICEFISH Cruise, RV Hespérides

description: ICEFISH Cruise (29HE20010119) carried out on the Research Vessel Hespérides in 2001
DOI: 10.5281/zenodo.4537099
title: Submission

description: Anonymous Submission
DOI: 10.5281/zenodo.4537098
title: Submission

description: Anonymous Submission
DOI: 10.26302/sshade/experiment_sb_20210129_001
title: T-dependent optical constants of FeO

description: Optical constants are obtained by reflectance measurements in a temperature range of 10 K to 300 K
DOI: 10.20351/29he20010514
title: GOLFO Cruise, RV Hespérides

description: GOLFO Cruise (29HE20010514) carried out on the Research Vessel Hespérides in 2001
DOI: 10.5281/zenodo.4537036
title: Applied pesticide toxicity shifts towards plants and invertebrates, even in GM crops

description: Supplemental data and R-scripts for Schulz et al. 2021, "Applied pesticide toxicity shifts towards plants and invertebrates, even in GM crops"
DOI: 10.5281/zenodo.4537035
title: Applied pesticide toxicity shifts towards plants and invertebrates, even in GM crops

description: Supplemental data and R-scripts for Schulz et al. 2021, "Applied pesticide toxicity shifts towards plants and invertebrates, even in GM crops"
DOI: 10.5281/zenodo.4537169
title: Dataset from Ranucci M, Sitzia C, Baryshnikova E, Di Dedda U, Cardani R, Martelli F, Corsi Romanelli M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome. J Clin Med. 2020 Oct 28;9(11):3487. doi: 10.3390/jcm9113487. PMID: 33126772; PMCID: PMC7692774.

description: Dataset from the article Ranucci M, Sitzia C, Baryshnikova E, Di Dedda U, Cardani R, Martelli F, Corsi Romanelli M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome. J Clin Med. 2020 Oct 28;9(11):3487. doi: 10.3390/jcm9113487. PMID: 33126772; PMCID: PMC7692774. <strong>Abstract</strong> <em>Background:</em> Coronavirus Disease 2019 (COVID-19)-associated coagulopathy is characterized by a prothrombotic state not yet comprehensively studied. We investigated the coagulation pattern of patients with COVID-19 acute respiratory distress syndrome (ARDS), comparing patients who survived to those who did not. <em>Methods:</em> In this prospective cohort study on 20 COVID-19 ARDS patients, the following biomarkers were measured: thrombin generation (prothrombin fragment 1 + 2 (PF 1 + 2)), fibrinolysis activation (tissue plasminogen activator (tPA)) and inhibition (plasminogen activator inhibitor 2 (PAI-2)), fibrin synthesis (fibrinopeptide A) and fibrinolysis magnitude (plasmin-antiplasmin complex (PAP) and D-dimers). Measurements were done upon intensive care unit (ICU) admission and after 10-14 days. <em>Results:</em> There was increased thrombin generation; modest or null release of t-PA; and increased levels of PAI-2, fibrinopeptide A, PAP and D-dimers. At baseline, nonsurvivors had a significantly (<em>p</em> = 0.014) higher PAI-2/PAP ratio than survivors (109, interquartile range (IQR) 18.1-216, vs. 8.7, IQR 2.9-12.6). At follow-up, thrombin generation was significantly (<em>p</em> = 0.025) reduced in survivors (PF 1 + 2 from 396 pg/mL, IQR 185-585 to 237 pg/mL, IQR 120-393), whereas it increased in nonsurvivors. Fibrinolysis inhibition at follow-up remained stable in survivors and increased in nonsurvivors, leading to a significant (<em>p</em> = 0.026) difference in PAI-2 levels (161 pg/mL, IQR 50-334, vs. 1088 pg/mL, IQR 177-1565). <em>Conclusion:</em> Severe patterns of COVID-19 ARDS are characterized by a thrombin burst and the consequent coagulation activation. Mechanisms of fibrinolysis regulation appear unbalanced toward fibrinolysis inhibition. This pattern ameliorates in survivors, whereas it worsens in nonsurvivors.
DOI: 10.5281/zenodo.4537168
title: Dataset from Ranucci M, Sitzia C, Baryshnikova E, Di Dedda U, Cardani R, Martelli F, Corsi Romanelli M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome. J Clin Med. 2020 Oct 28;9(11):3487. doi: 10.3390/jcm9113487. PMID: 33126772; PMCID: PMC7692774.

description: Dataset from the article Ranucci M, Sitzia C, Baryshnikova E, Di Dedda U, Cardani R, Martelli F, Corsi Romanelli M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome. J Clin Med. 2020 Oct 28;9(11):3487. doi: 10.3390/jcm9113487. PMID: 33126772; PMCID: PMC7692774. <strong>Abstract</strong> <em>Background:</em> Coronavirus Disease 2019 (COVID-19)-associated coagulopathy is characterized by a prothrombotic state not yet comprehensively studied. We investigated the coagulation pattern of patients with COVID-19 acute respiratory distress syndrome (ARDS), comparing patients who survived to those who did not. <em>Methods:</em> In this prospective cohort study on 20 COVID-19 ARDS patients, the following biomarkers were measured: thrombin generation (prothrombin fragment 1 + 2 (PF 1 + 2)), fibrinolysis activation (tissue plasminogen activator (tPA)) and inhibition (plasminogen activator inhibitor 2 (PAI-2)), fibrin synthesis (fibrinopeptide A) and fibrinolysis magnitude (plasmin-antiplasmin complex (PAP) and D-dimers). Measurements were done upon intensive care unit (ICU) admission and after 10-14 days. <em>Results:</em> There was increased thrombin generation; modest or null release of t-PA; and increased levels of PAI-2, fibrinopeptide A, PAP and D-dimers. At baseline, nonsurvivors had a significantly (<em>p</em> = 0.014) higher PAI-2/PAP ratio than survivors (109, interquartile range (IQR) 18.1-216, vs. 8.7, IQR 2.9-12.6). At follow-up, thrombin generation was significantly (<em>p</em> = 0.025) reduced in survivors (PF 1 + 2 from 396 pg/mL, IQR 185-585 to 237 pg/mL, IQR 120-393), whereas it increased in nonsurvivors. Fibrinolysis inhibition at follow-up remained stable in survivors and increased in nonsurvivors, leading to a significant (<em>p</em> = 0.026) difference in PAI-2 levels (161 pg/mL, IQR 50-334, vs. 1088 pg/mL, IQR 177-1565). <em>Conclusion:</em> Severe patterns of COVID-19 ARDS are characterized by a thrombin burst and the consequent coagulation activation. Mechanisms of fibrinolysis regulation appear unbalanced toward fibrinolysis inhibition. This pattern ameliorates in survivors, whereas it worsens in nonsurvivors.
DOI: 10.5517/ccdc.csd.cc25mbbh
title: CCDC 2014576: Experimental Crystal Structure Determination

description: Related Article: Aikaterini Vriza, Angelos B. Canaj, Rebecca Vismara, Laurence J. Kershaw Cook, Troy D. Manning, Michael W. Gaultois, Peter A. Wood, Vitaliy Kurlin, Neil Berry, Matthew S. Dyer, Matthew J. Rosseinsky|2021|Chemical Science|12|1702|doi:10.1039/D0SC04263C
DOI: 10.5517/ccdc.csd.cc25mbcj
title: CCDC 2014577: Experimental Crystal Structure Determination

description: Related Article: Aikaterini Vriza, Angelos B. Canaj, Rebecca Vismara, Laurence J. Kershaw Cook, Troy D. Manning, Michael W. Gaultois, Peter A. Wood, Vitaliy Kurlin, Neil Berry, Matthew S. Dyer, Matthew J. Rosseinsky|2021|Chemical Science|12|1702|doi:10.1039/D0SC04263C
DOI: 10.5517/ccdc.csd.cc26ljjw
title: CCDC 2043598: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljkx
title: CCDC 2043599: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljly
title: CCDC 2043600: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljmz
title: CCDC 2043601: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljp1
title: CCDC 2043603: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljq2
title: CCDC 2043604: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljr3
title: CCDC 2043605: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljs4
title: CCDC 2043606: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.5517/ccdc.csd.cc26ljt5
title: CCDC 2043607: Experimental Crystal Structure Determination

description: Related Article: Nicholas P. Funnell, David R. Allan, Andrew G. P. Maloney, Ronald I. Smith, Cameron J. G. Wilson, Simon Parsons|2021|CrystEngComm|23|769|doi:10.1039/D0CE01636E
DOI: 10.25919/6ny5-7m28
title: August 2019 Ningaloo DMR BRUV field trip - part 4 of 5

description: Name, Brief Description and owner: Baited Remote Underwater stereo-Video (BRUV) systems (6 in total) were used. All equipment (BRUVs, weights, cameras, lights, ropes, etc.) belonged to UWA Relevant component details: make, model, serial number, firmware version, settings: Stereo‐BRUV systems consisted of a frame, protecting 2 convergent video cameras inside waterproof housings (plus one rear-facing video camera) and 2 lights (one forward-facing and one rear-facing), attached to a base bar, with a baited container fixed in front of the cameras. Systems were tethered by rope to surface buoys to facilitate relocation and retrieval. Weights were added to frames due to the current and depth in the area. Cameras used: 2 x Canon HG 25 (forward facing) with the follow settings: • Focus: Manual (3.0m) • Rec Program: P) • Image stabilizer: OFF • Facial recognition: OFF • Recording mode: MXP • Frame rate: PF25 1 x GoPro Hero 3+ (backwards facing), taking photos every 60 seconds. Cameras were calibrated at UWA prior to and at the conclusion of the field trip, using SeaGIS software Cal. Contains files: 13.02.*.avi to 23.09.*.avi
DOI: 10.20351/29he20010907
title: HITS Cruise, RV Hespérides

description: HITS Cruise (29HE20010907) carried out on the Research Vessel Hespérides in 2001
DOI: 10.20351/29he20011206
title: COHIMAR Cruise, RV Hespérides

description: COHIMAR Cruise (29HE20011206) carried out on the Research Vessel Hespérides in 2001
DOI: 10.20351/29he20011028
title: FICARAM-III Cruise, RV Hespérides

description: FICARAM-III Cruise (29HE20011028) carried out on the Research Vessel Hespérides in 2001
DOI: 10.6084/m9.figshare.13949703
title: Data of occurrences of disasters from Climate change affected the spatio-temporal occurrence of disasters in China over the past five centuries

description: Climate change may contribute to the spatio-temporal occurrence of disasters. Long-term studies of either homogeneous or heterogeneous responses of historical disasters to climate change are, however, limited by the quality and quantity of the available proxy data. Here we reconstruct spatio-temporal patterns of five types of disasters in China during the period AD 1368–1911. Our analyses of these time series reveal that warmer temperatures decreased the occurrence of disasters in the monsoon-affected parts of central-east China, but it increased the frequency and intensity of disasters along the boundary of arid and humid conditions in parts of southwest and northeast China, likely driven by the interplay among monsoon, westerlies, polar vortex and variation of temperature. Moreover, we show that drought and flood events had cascading effects on the occurrences of locust outbreaks, famine and human epidemics. Our findings suggest that climate can contribute to the spatio-temporal occurrence of disasters, and therefore may contribute to an improvement of China's regional to national risk management of future climate and environmental change.
DOI: 10.20351/29he20010305
title: FICARAM-II Cruise, RV Hespérides

description: FICARAM-II Cruise (29HE20010305) carried out on the Research Vessel Hespérides in 2001
DOI: 10.6084/m9.figshare.13096061.v1
title: "Taxonomic, phylogenetic and functional diversity of forest understorey plants in European forest edges"

description: Data used for the article "Taxonomic, phylogenetic and functional diversity of forest understorey plants in European forest edges"
DOI: 10.6084/m9.figshare.13948868
title: PREFECT GWAS summary statistics

description: GWAS summary statistics described in the publication: <br>Clements, C.C., Karlsson, R., Lu, Y. <i>et al.</i> Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy. <i>Mol Psychiatry</i> (2021). https://doi.org/10.1038/s41380-020-00984-0<br>Two datasets were provided corresponding to the <i>broad</i> and <i>narrow</i> definitions, see the study info in the VCF results files and the publication for more details.
DOI: 10.20351/29he20010801
title: ZEE-2001 Cruise, RV Hespérides

description: ZEE-2001 Cruise (29HE20010801) carried out on the Research Vessel Hespérides in 2001
DOI: 10.20351/29he20021028
title: FICARAM-V Cruise, RV Hespérides

description: FICARAM-V Cruise (29HE20021028) carried out on the Research Vessel Hespérides in 2002
DOI: 10.5281/zenodo.4537187
title: Cross-Layer Deanonymization Methods in the Lightning Protocol

description: Dataset retrieved and used with the code hosted here for this paper published at FC '21. Abstract Bitcoin (BTC) pseudonyms (layer 1) can effectively be deanonymized using heuristic clustering techniques. However, while performing transactions off-chain (layer 2) in the Lightning Network (LN) seems to enhance privacy, a systematic analysis of the anonymity and privacy leakages due to the interaction between the two layers is missing. We present clustering heuristics that group BTC addresses, based on their interaction with the LN, as well as LN nodes, based on shared naming and hosting information. We also present linking heuristics that link 45.97% of all LN nodes to 29.61% BTC addresses interacting with the LN. These links allow us to attribute information (e.g., aliases, IP addresses) to 21.19% of the BTC addresses contributing to their deanonymization. Further, these deanonymization results suggest that the security and privacy of LN payments are weaker than commonly believed, with LN users being at the mercy of as few as five actors that control 36 nodes and over 33% of the total capacity. Overall, this is the first paper to present a method for linking LN nodes with BTC addresses across layers and to discuss privacy and security implications.