cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15151/esrf-es-906376984
title: STRUCTURAL BASES OF REGULATION OF SKELETAL MUSCLE

description: Muscle contraction is regulated by both Ca2+ dependent thin filament activation and mechanosensing-based thick filament activation that switches ON the motors in relation to the load. Evidence is growing for the involvement in thick filament regulation of the cytoskeleton protein titin, which runs from the midpoint of the thick filament to the end of the sarcomere, and the myosin binding protein C (MyBP-C), which is bound to the backbone of the thick filament in its central one-third and bridges thin and thick filaments. We use X-ray diffraction to investigate MyBP-C role in inter-filament communication and titin role in thick filament mechanosensing. The experiments, conducted in intact frog skeletal muscle fibres, exploit the finding that X-ray fine structure of myosin based reflections reports the footprints of both MyBP-C and titin and represent a testbed for future investigation on skinned fibres and whole muscles of rodent models with mutations in specific proteins.
DOI: 10.15151/esrf-es-949923993
title: Molecular bases of regulation of cardiac muscle contractility

description: Regulation of heart contractility is operated by both thin, actin containing filaments, and thick, myosin containing filaments. Ca2+-induced structural changes in the regulatory proteins of the thin filament release the actin sites for interaction with myosin motors. Thick filament mechanosensing adapts to the load the number of motors recruited from the OFF state in which they lie tilted back on their tails unable to interact with actin. In the heartbeat both thin and thick filament activations are under the control of modulatory mechanisms by accessory proteins. Mutations in these proteins cause dysregulation and cardiomyopathy. We use sarcomere-level mechanics and X-ray diffraction on intact and demembranated myocytes of the ventricle of wild type, mutant and transgenic animal models to investigate the mechanisms that control thick filament regulation/dysregulation and test small molecules candidate as therapeutic tools.
DOI: 10.15151/esrf-es-905036842
title: Cadmium detoxification mechanisms in cacao tissues

description: The new EU regulation on cadmium (Cd) concentration in cocoa-derived products affects the cocoa market worldwide, especially in Latin-America, and requires the development of mitigation strategies. Plant breeding to produce low Cd-accumulating cocoa cultivars is one of them. However, this strategy requires a much better understanding and control of the physiological pathways of Cd uptake, translocation and accumulation in the beans. The various plant parts (root, branch, leaves and bean) of a cacao tree were sampled in the field and investigated in a combined approach (elemental analyses, Cd stable isotope analyses, bulk XANES spectroscopy and LA ICP MS imaging). We identified the branches and the leaves as the major storage compartments for Cd. To test their role as a sink, but also as a source of Cd for the bean, we wish to determine the Cd distribution and speciation in these tissues using µXRF and µXANES.
DOI: 10.14457/nida.the.2014.37
title: The evaluation of Thailand higher education quality assessment criteria : a case study of the office for national education standard and quality assessment (public organization)
DOI: 10.15151/esrf-es-903918929
title: Resonant Inelastic X-ray Scattering study of charge density waves in highly overdoped superconducting La2-xCaxCuO4 thin films

description: Charge density wave (CDW) order was observed in all cuprate families and most studies to date showed that CDW correlations are confined to the underdoped regime. However, recent studies revealed the presence of CDW even in the overdoped regime. Our group recently succeeded in growing high quality thin films of La2-xCaxCuO4 (LCCO) in the overdoped regime with dopings up to x = 0.5 and observed that superconductivity surprisingly persists even at such high dopings, with Tc ~ 20 K at x = 0.5. Here, we propose to carry out high-resolution Cu-L3 resonant inelastic x-ray scattering (RIXS) on these LCCO thin films to investigate the presence of CDW order and provide a conclusion as to whether the CDW in the overdoped regime is a universal feature of cuprate supercondcutors.
DOI: 10.15151/esrf-es-902986011
title: Fundamental study of ionics in single-digit confinement

description: The formation of ion pairs is not taken into account by the continuous models of the aqueous solution transport in single-digit nanoconfinement. This is really important since we found recently that it leads to metastable phase formation and to pore clogging. The goal of this project is to characterize the transport of electrolyte solutions having ions of various size and different ability to form ion pairs in silica nanochannels with a gap of 1, 2, 3 and 5 nm using hard X-ray reflectivity. Coupled to ongoing atomistic modelling, these results will give reliable information such as the electron density profiles and the ion distributions, enabling a better fundamental understanding of the ions and water transport in single-digit confinement.
DOI: 10.14457/nida.the.2014.38
title: Social networking sites impacts on interpersonal communication skills and relationships
DOI: 10.15151/esrf-es-902094771
title: Probing the structure of photoluminescent Ag2S-based quantum dots in hepatic cells

description: Silver sulphide (Ag2S) quantum dots (QD) are semiconductor nanocrystal with outstanding optical properties as a broad absorption spectrum and narrow and tuneable emission in the Near-Infrared domain. Ag2S is a non-toxic material, which makes these QD eligible for in vivo imaging and drug delivery. However, their stability in biological systems and their biocompatibility need to be assessed before any in vivo application. We are currently developing Ag2S QDs with different sizes and coatings, in order to optimize their optical properties. We propose to make use of XAFS to investigate the stability of these different formulations in cellular models, including in 3D cell cultures mimicking the liver. This information, corroborated by their photophysical characterization and by cytotoxicity assays, will help us identify the best candidates for the development of nanoplatforms for imaging and therapy.
DOI: 10.15151/esrf-es-902100581
title: Tracking the evolution of transition metal single atom catalysts for the CO2 electroreduction: an operando HERFD XANES and XES study

description: Transition metal-nitrogen-doped carbons (TMNCs) are an attractive class of systems that shows promise application for the CO2 electroreduction reaction (CO2RR). However, despite important advances in the field, some open questions remain about the nature, stability and evolution of the possible metal active sites during CO2RR under static and pulsed potential conditions. Herein, we propose, for the first time, an operando combined a HERFD XANES and XES study targeting the CO2RR active species for a series of TMNCs materials (Co, Cu, Fe and Ni TMNCs), relevant for CO2RR research. The unique structure/electronic sensitivity of these spectroscopic techniques will be fundamental to have access the finest spectral features characterizing the CO2RR active centers, their reactive intermediates and possible C/O ligands, allowing us to clarify the main reaction steps and explain the TMNCs catalytic properties.
DOI: 10.14457/nida.the.2014.39
title: Engagement 2.0 - could enterprise 2.0 really improve the work engagement of your employees?
DOI: 10.14457/nida.the.2014.40
title: The role of interest rate in attracting FDI : a study on the Asean 5 economy
DOI: 10.14457/nida.the.2015.78
title: Major factors affecting foreign investment policy implementation effectiveness : the case of Mongolia
DOI: 10.14457/nida.the.2015.79
title: Key success factors in the organic agriculture policy implementation
DOI: 10.14457/nida.the.2014.41
title: The achievement of export performance of small and medium enterprises (SMEs) in Thailand
DOI: 10.14457/nida.the.2016.128
title: The effects of collectivism-high performance work system and leader-member-exchange on organizational performance in the Thai hospitality industry
DOI: 10.14457/nida.the.2016.129
title: Factors involved with the cooperation of traffic police in accordance with law enforcement on road safety policy implementation : a case of non-helmet use among motorcyclists
DOI: 10.14457/nida.the.2015.80
title: Effectiveness : the case study of hotels in Bangkok
DOI: 10.14457/nida.the.2009.120
title: ปัจจัยที่มีผลต่อประสิทธิผลของนโยบายบรรษัทภิบาล : กรณีบริษัทจดทะเบียน
DOI: 10.14457/nida.the.1990.4
title: อุปทานและอุปสงค์ของพยาบาลวิชาชีพในประเทศไทยระหว่าง พ.ศ. 2531-2000
DOI: 10.14457/nida.the.2014.42
title: การวิจัยเพื่อพัฒนาและประเมินเครื่องมือวัดพฤติกรรมความปลอดภัยระหว่างบุคคลใน Facebook และสถานการณ์จริงของนักศึกษาปริญญาตรีและความไม่แปรเปลี่ยนของโมเดลการวัด
DOI: 10.14457/nida.the.2013.29
title: การคาดการณ์ต้นทุนสิ่งแวดล้อมของการเติบโตทางเศรษฐกิจในประเทศไทย
DOI: 10.14457/nida.the.2016.130
title: ปัจจัยพยากรณ์การใช้งานการพาณิชย์ผ่านเครือข่ายสังคมออนไลน์
DOI: 10.14457/nida.the.2018.83
title: การส่งผ่านผลกระทบจากความไม่แน่นอนของนโยบายเศรษฐกิจต่างประเทศต่อตลาดหลักทรัพย์ในประเทศไทย
DOI: 10.14457/nida.the.2014.43
title: คุณภาพชีวิตการทำงานของพนักงานการเคหะแห่งชาติ : กรณีศึกษาพนักงานผู้ปฏิบัติหน้าที่ในสำนักงานใหญ่
DOI: 10.14457/nida.the.2014.44
title: พฤติกรรมการบริโภค การเป็นหนี้ และคุณภาพชีวิต ของชาวประมงทะเล ในตาบลสิชล อำเภอสิชล จังหวัดนครศรีธรรมราช
DOI: 10.14457/nida.the.2014.45
title: ยุทธศาสตร์พลังงานสีเขียวจังหวัดสิงห์บุรี
DOI: 10.14457/nida.the.2014.46
title: ความสามารถทนเค็มน้าทะเลของสายพันธุ์หญ้าแฝก
DOI: 10.14457/nida.the.2014.47
title: การจัดการขยะตรวจค้นของอาคารผู้โดยสารขาออกท่าอากาศยานสุวรรณภูมิ
DOI: 10.14457/nida.the.2018.84
title: ปัจจัยทางจิตลักษณะและสถานการณ์ที่เกี่ยวข้องกับพฤติกรรมมุ่งมั่นในการเรียนของนักศึกษาระดับปริญญาตรีที่เป็นรุ่นแรกของครอบครัว
DOI: 10.14457/nida.the.2014.48
title: กระบวนการยุติธรรมเชิงสมานฉันท์ : กรณีศึกษาสำนักงานยุติธรรมจังหวัดมหาสารคาม
DOI: 10.14457/nida.the.2018.85
title: การตรวจจับรูปแบบผิดปกติของการเบิกจ่ายค่ารักษาพยาบาลด้วย Decision tree
DOI: 10.14457/nida.the.2014.49
title: มาตรการทางกฎหมายในการคุ้มครองผู้บริโภค: ศึกษากรณี ผลิตภัณฑ์แว่นกันแดด
DOI: 10.14457/nida.the.2014.50
title: การรับรู้ข่าวสารการตลาดและการตัดสินใจซื้อเครื่องสำอางของคนรุ่นใหม่เพศหญิงผ่านกูรูความงาม
DOI: 10.14457/nida.the.2014.51
title: การวิเคราะห์คลิปวิดีโอไวรัลมาร์เก็ตติ้งและปัจจัยที่มีผลต่อการตัดสินใจแบ่งปัน
DOI: 10.14457/nida.the.2013.30
title: การวางแผนการลงทุนสำหรับวัยเกษียณ
DOI: 10.14457/nida.the.2012.1
title: การเปลี่ยนแปลงโครงสร้างประชากรกับความอยู่ดีกินดีของคนไทย
DOI: 10.14457/nida.the.2015.81
title: การประเมินมูลค่าทางเศรษฐศาสตร์ของผืนป่าทิวเขาถนนธงชัยตะวันออก
DOI: 10.14457/nida.the.2014.52
title: กลุ่มพันธมิตรสายการบิน : ผลกระทบต่อราคาค่าโดยสารและรายรับของสายการบินในเส้นทางระหว่างศูนย์กลางข้ามมหาสมุทรแปซิฟิค
DOI: 10.14457/nida.the.2014.53
title: ความเหลื่อมล้ำระหว่างระบบประกันสุขภาพของภาครัฐในประเทศไทย
DOI: 10.14457/nida.the.2014.54
title: อัตราการคงอยู่และความเหลื่อมล้ำทางการศึกษา
DOI: 10.14457/nida.the.2013.31
title: การศึกษาความสามารถในการแข่งขันของตลาดหลักทรัพย์ไทยในอาเซียน 5
DOI: 10.14457/nida.the.2015.82
title: ความสัมพันธ์เชิงโครงสร้างระหว่างความผูกพันต่อองค์กร การสร้างเสริมความสามารถของพนักงานและประสิทธิผลในการปฏิบัติงานของวิทยาลัยอาชีวศึกษา สังกัดสำนักคณะกรรมการอาชีวศึกษา เขตพื้นที่กรุงเทพมหานคร
DOI: 10.6084/m9.figshare.21276306
title: Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters

description: Although pharmaceutical companies have to study drug-transporter interaction, environmental contaminant interactions with these transporters are not well characterised. In this study, we demonstrated using <i>in vitro</i> transfected cell line that some organophosphorus pesticides are able to interact with drug efflux transporters like P-glycoprotein, BCRP and MRPs.According to our results, dibrom was found to inhibit only Hoechst binding site of P-gp with an IC<sub>50</sub> closed to 77 µM, phosmet inhibited BCRP efflux with an IC<sub>50</sub> of 42 µM and only profenofos was able to inhibit BCRP, MRPs and P-gp at two binding sites. As profenofos appeared to be a potent ABC transporter inhibitor, we studied its potential substrate property towards P-gp.Using a docking approach, we developed an in silico tool to study pesticide properties to be a probe or inhibitor of P-gp transporter. From both <i>in silico</i> and <i>in vitro</i> results, profenofos was not considered as a P-gp substrate.Combining both in vitro and docking methods appears to be an attractive approach to select pesticides that would not pass into the blood systemic circulation. Although pharmaceutical companies have to study drug-transporter interaction, environmental contaminant interactions with these transporters are not well characterised. In this study, we demonstrated using <i>in vitro</i> transfected cell line that some organophosphorus pesticides are able to interact with drug efflux transporters like P-glycoprotein, BCRP and MRPs. According to our results, dibrom was found to inhibit only Hoechst binding site of P-gp with an IC<sub>50</sub> closed to 77 µM, phosmet inhibited BCRP efflux with an IC<sub>50</sub> of 42 µM and only profenofos was able to inhibit BCRP, MRPs and P-gp at two binding sites. As profenofos appeared to be a potent ABC transporter inhibitor, we studied its potential substrate property towards P-gp. Using a docking approach, we developed an in silico tool to study pesticide properties to be a probe or inhibitor of P-gp transporter. From both <i>in silico</i> and <i>in vitro</i> results, profenofos was not considered as a P-gp substrate. Combining both in vitro and docking methods appears to be an attractive approach to select pesticides that would not pass into the blood systemic circulation.
DOI: 10.6084/m9.figshare.21276306.v1
title: Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters

description: Although pharmaceutical companies have to study drug-transporter interaction, environmental contaminant interactions with these transporters are not well characterised. In this study, we demonstrated using <i>in vitro</i> transfected cell line that some organophosphorus pesticides are able to interact with drug efflux transporters like P-glycoprotein, BCRP and MRPs.According to our results, dibrom was found to inhibit only Hoechst binding site of P-gp with an IC<sub>50</sub> closed to 77 µM, phosmet inhibited BCRP efflux with an IC<sub>50</sub> of 42 µM and only profenofos was able to inhibit BCRP, MRPs and P-gp at two binding sites. As profenofos appeared to be a potent ABC transporter inhibitor, we studied its potential substrate property towards P-gp.Using a docking approach, we developed an in silico tool to study pesticide properties to be a probe or inhibitor of P-gp transporter. From both <i>in silico</i> and <i>in vitro</i> results, profenofos was not considered as a P-gp substrate.Combining both in vitro and docking methods appears to be an attractive approach to select pesticides that would not pass into the blood systemic circulation. Although pharmaceutical companies have to study drug-transporter interaction, environmental contaminant interactions with these transporters are not well characterised. In this study, we demonstrated using <i>in vitro</i> transfected cell line that some organophosphorus pesticides are able to interact with drug efflux transporters like P-glycoprotein, BCRP and MRPs. According to our results, dibrom was found to inhibit only Hoechst binding site of P-gp with an IC<sub>50</sub> closed to 77 µM, phosmet inhibited BCRP efflux with an IC<sub>50</sub> of 42 µM and only profenofos was able to inhibit BCRP, MRPs and P-gp at two binding sites. As profenofos appeared to be a potent ABC transporter inhibitor, we studied its potential substrate property towards P-gp. Using a docking approach, we developed an in silico tool to study pesticide properties to be a probe or inhibitor of P-gp transporter. From both <i>in silico</i> and <i>in vitro</i> results, profenofos was not considered as a P-gp substrate. Combining both in vitro and docking methods appears to be an attractive approach to select pesticides that would not pass into the blood systemic circulation.
DOI: 10.6084/m9.figshare.20783938
title: Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established <i>in vitro</i> to <i>in vivo</i> extrapolation methodologies

description: The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate <i>in vitro</i> to <i>in vivo</i> extrapolation (IVIVE) methodologies for prediction of hepatic, metabolic clearance (<i>CL<sub>hep,met</sub>)</i> in Göttingen minipig, using a comprehensive set of compounds.<i>In vivo</i> clearance was determined in Göttingen minipig by intravenous cassette dosing and hepatocyte intrinsic clearance, plasma protein binding and non-specific incubation binding were determined <i>in vitro</i>. Prediction of <i>CL<sub>hep,met</sub></i> was performed by IVIVE using conventional and adapted formats of the well-stirred liver model.The best prediction of <i>in vivo CL<sub>hep,met</sub></i> from scaled <i>in vitro</i> kinetic data was achieved using an empirical correction factor based on a ‘regression offset’ of the IVIV relationship.In summary, these results expand the <i>in vitro</i> and <i>in vivo</i> PK knowledge in Göttingen minipig. We show regression corrected IVIVE provides superior prediction of <i>in vivo CL<sub>hep,met</sub></i> in minipig offering a practical, unified scaling approach to address systematic under-predictions. Finally, we propose a reference set for researchers to establish their own ‘lab-specific’ regression correction for IVIVE in minipig. The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate <i>in vitro</i> to <i>in vivo</i> extrapolation (IVIVE) methodologies for prediction of hepatic, metabolic clearance (<i>CL<sub>hep,met</sub>)</i> in Göttingen minipig, using a comprehensive set of compounds. <i>In vivo</i> clearance was determined in Göttingen minipig by intravenous cassette dosing and hepatocyte intrinsic clearance, plasma protein binding and non-specific incubation binding were determined <i>in vitro</i>. Prediction of <i>CL<sub>hep,met</sub></i> was performed by IVIVE using conventional and adapted formats of the well-stirred liver model. The best prediction of <i>in vivo CL<sub>hep,met</sub></i> from scaled <i>in vitro</i> kinetic data was achieved using an empirical correction factor based on a ‘regression offset’ of the IVIV relationship. In summary, these results expand the <i>in vitro</i> and <i>in vivo</i> PK knowledge in Göttingen minipig. We show regression corrected IVIVE provides superior prediction of <i>in vivo CL<sub>hep,met</sub></i> in minipig offering a practical, unified scaling approach to address systematic under-predictions. Finally, we propose a reference set for researchers to establish their own ‘lab-specific’ regression correction for IVIVE in minipig.
DOI: 10.6084/m9.figshare.20783938.v1
title: Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established <i>in vitro</i> to <i>in vivo</i> extrapolation methodologies

description: The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate <i>in vitro</i> to <i>in vivo</i> extrapolation (IVIVE) methodologies for prediction of hepatic, metabolic clearance (<i>CL<sub>hep,met</sub>)</i> in Göttingen minipig, using a comprehensive set of compounds.<i>In vivo</i> clearance was determined in Göttingen minipig by intravenous cassette dosing and hepatocyte intrinsic clearance, plasma protein binding and non-specific incubation binding were determined <i>in vitro</i>. Prediction of <i>CL<sub>hep,met</sub></i> was performed by IVIVE using conventional and adapted formats of the well-stirred liver model.The best prediction of <i>in vivo CL<sub>hep,met</sub></i> from scaled <i>in vitro</i> kinetic data was achieved using an empirical correction factor based on a ‘regression offset’ of the IVIV relationship.In summary, these results expand the <i>in vitro</i> and <i>in vivo</i> PK knowledge in Göttingen minipig. We show regression corrected IVIVE provides superior prediction of <i>in vivo CL<sub>hep,met</sub></i> in minipig offering a practical, unified scaling approach to address systematic under-predictions. Finally, we propose a reference set for researchers to establish their own ‘lab-specific’ regression correction for IVIVE in minipig. The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate <i>in vitro</i> to <i>in vivo</i> extrapolation (IVIVE) methodologies for prediction of hepatic, metabolic clearance (<i>CL<sub>hep,met</sub>)</i> in Göttingen minipig, using a comprehensive set of compounds. <i>In vivo</i> clearance was determined in Göttingen minipig by intravenous cassette dosing and hepatocyte intrinsic clearance, plasma protein binding and non-specific incubation binding were determined <i>in vitro</i>. Prediction of <i>CL<sub>hep,met</sub></i> was performed by IVIVE using conventional and adapted formats of the well-stirred liver model. The best prediction of <i>in vivo CL<sub>hep,met</sub></i> from scaled <i>in vitro</i> kinetic data was achieved using an empirical correction factor based on a ‘regression offset’ of the IVIV relationship. In summary, these results expand the <i>in vitro</i> and <i>in vivo</i> PK knowledge in Göttingen minipig. We show regression corrected IVIVE provides superior prediction of <i>in vivo CL<sub>hep,met</sub></i> in minipig offering a practical, unified scaling approach to address systematic under-predictions. Finally, we propose a reference set for researchers to establish their own ‘lab-specific’ regression correction for IVIVE in minipig.
DOI: 10.6084/m9.figshare.20402439
title: Narrative Details.zip

description: narrative details from the results of interviews and Forum Group Discussion (FGD) with the research title "Impact Of The Covid-19 Pandemic On Women Entrepreneurs In Sukoharjo Regency."
DOI: 10.6084/m9.figshare.20402439.v1
title: Narrative Details.zip

description: narrative details from the results of interviews and Forum Group Discussion (FGD) with the research title "Impact Of The Covid-19 Pandemic On Women Entrepreneurs In Sukoharjo Regency."
DOI: 10.5281/zenodo.6458293
title: The scaled-invariant Planckian metal and quantum criticality in Ce$_{1-x}$Nd$_x$CoIn$_5$

description: Codes and data for each figure created for the study in <em>The scaled-invariant Planckian metal and quantum criticality in Ce$_{1-x}$Nd$_x$CoIn$_5$.</em>
DOI: 10.5281/zenodo.6458292
title: The scaled-invariant Planckian metal and quantum criticality in Ce$_{1-x}$Nd$_x$CoIn$_5$

description: Updated version of the codes and data for each figure created for the study in <em>The scaled-invariant Planckian metal and quantum criticality in Ce$_{1-x}$Nd$_x$CoIn$_5$.</em>
DOI: 10.5281/zenodo.7187946
title: The scaled-invariant Planckian metal and quantum criticality in Ce$_{1-x}$Nd$_x$CoIn$_5$

description: Updated version of the codes and data for each figure created for the study in <em>The scaled-invariant Planckian metal and quantum criticality in Ce$_{1-x}$Nd$_x$CoIn$_5$.</em>