cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28731005.v1
title: Supplementary Material for: Repeated kidney biopsy in membranoproliferative glomerulonephritis

description: Introduction: Membranoproliferative glomerulonephritis (MPGN) is a heterogeneous pattern of glomerular injury. Repeated kidney biopsies may elucidate pathogenic mechanisms and guide diagnostic strategies.
Methods: We included 82 patients diagnosed with MPGN by kidney biopsy who underwent at least two biopsies between 1997 and 2023 at Peking University First Hospital. Clinical and pathological data were analyzed retrospectively.
Results: Of 342 MPGN patients, 95 (28%) had repeated biopsies (0.9–4.0 years apart). This incidence was higher than in other glomerulonephropathies under immunosuppression. Among the 82 patients analyzed (excluding kidney transplants and ≤3-month biopsy intervals), 42 were initially diagnosed with non-MPGN pathology. At the second biopsy, proteinuria increased (mean 2.9 to 6.3 g/day), eGFR declined (76 to 47 mL/min/1.73 m²), and renal C3 deposition was stronger (P=0.03). Thirty patients (37%) had etiological reclassification, mostly to monoclonal gammopathy of renal significance (MGRS). Compared to idiopathic MPGN, MGRS patients were older (53 vs. 35 years) and had worse renal function (eGFR 57 vs. 81 mL/min/1.73 m²) but slower eGFR decline (-7 vs. -12 mL/min/1.73 m²/year). Most MGRS patients (64%) remained negative for monoclonal protein in serum or urine immunofixation, necessitating repeat biopsy and clone-directed therapy. 
Conclusions: In this study, about half and one-third of patients underwent morphological and etiological reclassification, respectively. Stronger complement deposition may drive morphological changes. Repeated kidney biopsies are crucial for diagnosing MGRS, especially in patients with negative immunofixation.
DOI: 10.17632/5jyjwhn7b4
title: Mediated-moderated effects: High and low store image, brand awareness, perceived value from mini and supermarkets retail stores

description: This work was supported by the [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES)] under Grant [Finance Code 001]; and [Conselho Nacional de Desenvolvimento Científico e Tecnológico] under Grant [Chamada MCTIC/CNPq Nº 28/2018 - Universal/Faixa C – number 409643/2018-1] and [Chamada CHAMADA MCTI/CNPQ/MEC/CAPES Nº 22/2014 – Ciências Humanas e Sociais].
DOI: 10.17632/f7ysn96hny
title: Data for: Searching FOIA Libraries for Government Information

description: This is an Excel spreadsheet containing links to 242 FOIA Libraries as of September 2019. This dataset provides naming conventions used, which allow government information consumers to locate U.S. federal agency FOIA content, which includes responsive documents and frequently requested agency records. This list of FOIA Libraries and related terminology (Electronic Reading Rooms) also helps researchers understand the evolution of FOIA Libraries.
DOI: 10.6084/m9.figshare.17059592.v2
title: Quality-controlled carbon-14 dates of steppe bison (Bison priscus) fossils

description: We gathered carbon-14-dated fossil records of the steppe bison (<i>Bison priscus</i>) from open access databases, quality-scored them using Barnosky & Lindsey criteria, and retained the records rated "reliable." We then calibrated the carbon-14 dates using the IntCal13 curve in OxCal.
DOI: 10.6084/m9.figshare.21707510.v2
title: modified IEEE-24 bus electricity system and Belgian 20-node gas system dataset

description: modified IEEE-24 bus electricity system coupled with Belgian 20-node gas system dataset
DOI: 10.6084/m9.figshare.23275823.v1
title: Supplementary Material for: Gastric Metastasis 5 Years after Primary Invasive Lobular Adenocarcinoma of the Breast

description: Breast cancers metastasize most commonly to the bone, brain, liver, and lungs, but rarely to the gastrointestinal tract. Although metastatic breast carcinomas in the stomach can be confused with primary gastric cancers due to their nonspecific presentation and rare incidence, it is important to differentiate the two since the treatment is different. Clinical suspicion is imperative for a prompt endoscopic evaluation and a definitive diagnosis that will lead to appropriate treatment. Therefore, it is important for clinicians to be aware of the possibility of gastric metastasis of breast cancers, especially in those with a history of invasive lobular breast carcinoma and a new onset of gastrointestinal symptoms.
DOI: 10.6084/m9.figshare.25621809.v2
title: Enhancing Genomic Assembly Accuracy Through Hybrid In Silico Library and Reference-Guided Misassembly Correction

description: After co-assembly of the draft genomes for <i>Megalobrama amblycephala</i> (GCA_009869865.1) and <i>Culter alburnus</i> (GCA_009869775.1, GCA_028476615.1) using the reference-guided assemblers Ragout v2.3 and Ragtag v2.1, we utilized <i>Culter erythropterus</i> (GCA_024489055.1), <i>C. alburnus</i> (GWHBOSX00000000), and <i>M. amblycephala</i> (GCA_018812025.1) as reference genomes. We employed the Ragtag Correct function along with an in silico paired-end 500 bp library to rectify misassemblies in the target genomes of <i>M. amblycephala</i> (GCA_009869865.1) and <i>C. alburnus</i> (GCA_009869775.1, GCA_028476615.1). This process yielded improved versions of the three genomic drafts designated cor_ma, cor_ca, and cor_ca_hu, respectively.
DOI: 10.17632/52f23whvdv
title: Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant

description: Companion data directories for the 2024 PNAS article.

Patrick Carmody,1† Francis J. Roushar,1† Austin Tedman,2 Wei Wang,3 Madeline Herwig,4 Minsoo Kim,4,5 Eli F. McDonald,4 Karen Noguera,1 Jennifer Wong-Roushar,1 Jon-Luc Poirier,1 Nathan B. Zelt,1 Ben T. Pockrass,1 Andrew G. McKee,1 Charles P. Kuntz,2 S. Vamsee Raju,3 Lars Plate,4,6 Wesley D. Penn,1* and Jonathan P. Schlebach2*

1 Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401
2 The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907
3 Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA 35233
4Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240
5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA 37240
6Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA 37240
DOI: 10.17632/899tntr9x2
title: Senoreverse candidate: miR-302b

description: This dataset contains supplementary Excel tables related to the manuscript "Exosomal miR-302b Rejuvenates Aging Mice by Reversing the Proliferative Arrest of Senescent Cells." The data includes detailed quantitative analyses that support the findings of the study, covering aspects such as gene expression, cytokine levels, cell cycle phases, and the effects of miR-302b treatment on senescent cells and aging tissues.
The dataset comprises the following tables:

Table S1: Bulk RNA-seq data from PDL50 IMR-90 cells treated with hESC-Exos.
Table S2: Cell cycle phase proportions from single-cell RNA sequencing (scRNA-seq) of liver and skin tissues in aging mice.
Table S3: Pseudotemporal analysis of senescent cells transitioning to rejuvenated states.
Table S4: Cytokine profiling in serum samples of aging mice treated with or without hESC-Exos.
Table S5: Annotation of cell types in scRNA-seq data of liver and skin.
Table S6: Differentially expressed genes (DEGs) related to rejuvenation following hESC-Exos treatment.
Table S7: Composition of cell ratios in different experimental groups.
Table S8: Proportions of cells in various phases of the cell cycle.
Table S9: Rescue cell cycle-related genes (CCGs) shared between liver and skin tissues.
Table S10: Pseudotemporal analysis of mitotic cells in liver and skin tissues.
Table S11: Results from Ago2 CLIP-Seq analysis identifying miR-302b target genes.
Table S12: Absolute quantification of miR-302b abundance in different tissues.
Table S13: Bulk RNA-seq data from multiple tissues comparing young, aging, and miR-302b-treated mice.
DOI: 10.17632/hc8gxwks3p
title: Cancer-Associated Fibroblasts Regulate Patient-Derived Organoid Drug Responses

description: This dataframe contains the full PDO + CAF screening developed and detailed in "Cancer-Associated Fibroblasts Regulate Patient-Derived Organoid Drug Responses", 2022 (https://www.biorxiv.org/content/10.1101/2022.10.19.512668v1). 
We developed a highly multiplexed thiol-reactive organoid barcoding in situ mass cytometry (TOBis MC) platform to perform single-cell post translational modification (PTM) signalling analysis of colorectal cancer (CRC) PDOs and cancer associated fibroblasts (CAFs) in response to clinical therapies. 

The dataframe is structured in rows that correspond to each single cell, and columns that include information on the PTM or protein measured, and the metadata (information on the provenance of each cell). 
Metadata columns include:
-Date: in format YYYMMDD, correspond to the date those rows were acquired.
-Patient: PDO number (5, 11, 21, 23, 27, 75, 99, 109, 141, 216)
-Culture: indicates the nature (monoculture/co-culture of the sample). PDO (PDO monoculture), F (CAF monoculture), PDOF (PDO+CAF co-culture).
-Treatment: drug(s) administered to each culture. The key for the drug labels appear detailed in Table S2 in the article referenced.
-Concentration: concentration used for each treatment. The key for the drug concentrations appear detailed in Table S2 in the article referenced.
-Replicate: treatment conditions were performed in triplicate (A, B, C) and control conditions in triplicate or duplicate (A, B, C, AA, BB, CC)
-Cell_type: refers to the cell-type of the cell gated (PDOs, or CAFs). In monocultures there is one cell type, and in co-cultures 2. 
-Plate: since different treatments contain different vehicle controls (DMSO, AH, O), the plate column helps to specify which vehicle corresponds to which treatments. This is important for pairing. 
-Batch: the data was acquired along 10 months, but the acquisition was performed in 2 general batches, with 5 months in between. However, for a more accurate batch representation, we recommend using the columns "Date" and "Patient".
DOI: 10.17632/yy68tb6fd4
title: Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma

description: Supplemental data files for Mäkelä et al. Supplemental data 1. Ex vivo drug screening results. Supplemental data 2. Ex vivo RNAi screening results.
DOI: 10.6084/m9.figshare.14669907.v1
title: FMEA Result.csv

description: The results of the FMEA Questionnaire assess the risk of failure of the solid waste management process
DOI: 10.6084/m9.figshare.21363075.v2
title: Practical Flaky Test Prediction using Common Code-Evolution and Test-History Data

description: Replication package.You can find the preprint of the paper here.
DOI: 10.6084/m9.figshare.7546724.v1
title: Supplementary Material for: Neurotoxicity of Unconjugated Bilirubin in Mature and Immature Rat Organotypic Hippocampal Slice Cultures

description: <b><i>Background:</i></b> The physiopathology of bilirubin-induced neurological disorders is not completely understood. <b><i>Objectives:</i></b> The aim of our study was to assess the effect on bilirubin neurotoxicity of the maturity or immaturity of exposed cells, the influence of different unconjugated bilirubin (UCB) and human serum albumin (HSA) concentrations, and time of UCB exposure. <b><i>Methods:</i></b> Organotypic<i></i> hippocampal slices were exposed for 48 h to different UCB and HSA concentrations after 14 (mature) or 7 (immature) days of in vitro culture. Immature slices were also exposed to UCB and HSA for 72 h. The different effects of exposure time to UCB on neurons and astrocytes were evaluated. <b><i>Results:</i></b> We found that 48 h of UCB exposure was neurotoxic for mature rat organotypic hippocampal slices while 72 h of exposure was neurotoxic for immature slices. Forty-eight-hour UCB exposure was toxic for astrocytes but not for neurons, while 72-h exposure was toxic for both astrocytes and neurons. HSA prevented UCB toxicity when the UCB:HSA molar ratio was ≤1 in both mature and immature slices. <b><i>Conclusions:</i></b> We confirmed UCB neurotoxicity in mature and immature rat hippocampal slices, although immature ones were more resistant. HSA was effective in preventing UCB neurotoxicity in both mature and immature rat hippocampal slices.
DOI: 10.17632/94t89wnrft
title: Dataset of Scival Media Exposure & Mass Media for the Council of Indian Institutes of Technology (CIIT) from 2019 to 2023

description: This is data for Scival Media Exposure (Print) & Mass Media (Print) for the Council of Indian Institutes of Technology (CIIT) from 2019 to 2023.
DOI: 10.6084/m9.figshare.7558454.v2
title: MR-SCUC.xlsx

description: This is a modified IEEE two-area test system, by joining the standard 118-bus and 39-bus systems. 24-hour wind power outputs and system load profiles are provided as well.
DOI: 10.6084/m9.figshare.9711164.v2
title: Metadata record for: A public data set of spatio-temporal match events in soccer competitions

description: This dataset contains key characteristics about the data described in the Data Descriptor A public data set of spatio-temporal match events in soccer competitions. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.1480957.v3
title: Variación de los niveles de glucosa sanguínea post-administración de un extracto acuoso de Moringa oleífera en adultos normoglicémicos

description: La Moringa oleífera es una especie vegetal utilizada en la medicina popular para el tratamiento de diversas enfermedades, entre ellas la Diabetes mellitus de tipo 2. El presente estudio tuvo como<br>objetivo determinar si el consumo de un extracto acuoso de Moringa oleífera (MO) al 10 %, ejercía un efecto sobre la glucosa sanguínea en adultos normo glicémicos, previa administración de 100g de glucosa anhidra, correlacionando dicha variación con la acción hipoglucemiante atribuida a la MO y verificando que tal efecto fuese debido al empleo de la planta ya mencionada. El modelo de estudio escogido fue cuasi experimental, de corte trasversal. Los resultados obtenidos demostraron que no fue visualizada una disminución significativa de la glucosa sanguínea, a la concentración del 10 % de un extracto acuoso de hojas Moringa oleífera en una única dosis de administración; desmitificando así, que la concentración de uso popular poseía mayores efectos sobre la glucosa sanguínea en periodos breves de tratamiento.
DOI: 10.6084/m9.figshare.21345177.v7
title: Arctic surface air temperatures from 1979-2022: A newly reconstructed data with deep learning method

description: The dataset provides 1°x1° monthly temperature anomalies (relative to 1981–2010 average) from 30°N to 90°N from 1979 to 2022.
DOI: 10.6084/m9.figshare.28855955.v2
title: Proposed Zone-Based Declustering Approach for Earthquake Catalogs

description: Declustering earthquake catalogs according to seismic zonation
DOI: 10.6084/m9.figshare.5125474.v1
title: Supplementary Material for: Endothelial Dysfunction Occurs prior to Clinical Evidence of Polycystic Kidney Disease

description: <b><i>Objective:</i></b> Polycystic kidney disease (PKD), a monogenic disease with an autosomal dominant or an autosomal recessive form of inheritance (ARPKD), is the most common genetic cause of renal dysfunction and end-stage renal failure. In addition to the development of cysts, the autosomal form of PKD is associated with vascular endothelial dysfunction, a marker of vascular disease. Whether vascular endothelial dysfunction is also present in ARPKD, and its relationship with renal dysfunction remain to be determined. <b><i>Methods:</i></b> ARPKD rats (PCK model) and controls were studied at 6 and 10 weeks of age, and mean arterial pressure and renal function were measured. Aortic endothelial function was assessed using organ chamber techniques. Aortic endothelial cells (ECs) were isolated, characterized and their function studied. <b><i>Results:</i></b> Compared to controls, ARPKD animals had a decrease in the vasorelaxation to endothelium-dependent vasodilators, even prior to changes in mean arterial pressure or renal function. The abnormal vasoreactivity was corrected with L-arginine (a precursor of nitric oxide, NO), while the expression of endothelial NO synthase (eNOS) was unchanged. Furthermore, isolated ECs from 6-week-old ARPKD animals showed increased oxidative stress, with preserved eNOS expression and abnormal patterns of migration and angiogenic capacity (measured by the scratch and tube formation assays, respectively). <b><i>Conclusion:</i></b> ARPKD leads to impairments in aortic vascular function and ECs at an early stage, which can have significant functional consequences, potentially representing a novel therapeutic target in this disease.
DOI: 10.6084/m9.figshare.20768575.v1
title: SNP matrix

description: contains phylip matrix with 88,369 SNPs sampled along the genome, used to construct Fig. 1, Supplementary Fig. 4 and 5 and Supplementary Table 1. <br>
DOI: 10.6084/m9.figshare.24041811.v1
title: Shared data and codes for fine root intraspecific trait variaiton

description: This work explores the latitudinal pattern of fine root intraspecific variation among plant species.
DOI: 10.6084/m9.figshare.5121358.v1
title: Supplementary Material for: Wie wirksam ist ein begleitendes Elterntraining in der Prävention von Angst und Depression bei Kindern?

description: <i>Hintergrund:</i> Angst- und depressive Störungen gehören zu den häufigsten Störungen des Kindes-und Jugendalters und beeinträchtigen die kindliche Entwicklung erheblich. Zur Prävention von Angststörungen und depressiven Erkrankungen haben sich kognitiv-verhaltenstherapeutische Programme als wirksam erwiesen, wobei die Kinder in unterschiedlichem Ausmaß profitieren. Ein möglicher Einflussfaktor des Präventionserfolgs wird im elterlichen Verhalten gesehen. Elterntrainings sollen Eltern helfen, ihren Umgang mit Problemen des Kindes zu modifizieren. Ziel unserer Studie ist es, die Wirksamkeit eines begleitenden Elterntrainings in der indizierten Prävention von Angst- und depressiven Störungen bei 8-bis 12-jährigen Kindern zu prüfen. <i>Patienten und Methoden:</i> 70 Kinder wurden randomisiert den Gruppen «Präventionskurs» oder «Präventionskurs + Elterntraining» zugeteilt. Grundlage des Präventionskurses war eine modifizierte Version des FREUNDE-Programms. Hauptkriterien zur Überprüfung der Wirksamkeit waren die Child Behavior Checklist, die Spence Children’s Anxiety Scale und das Depressionsinventar für Kinder und Jugendliche. Die Auswertung der Daten erfolgte varianzanalytisch (MANOVA). <i>Ergebnisse:</i> Das Elterntraining hatte keinen signifikanten Effekt auf die Veränderung introversiver Symptome. Bei stärkerer psychopathologischer Belastung der Eltern zeigte sich eine deutlichere Symptomreduktion der Kinder – unabhängig von der Teilnahme am Elterntraining. Alle Eltern erlebten sich mit Abschluss des Präventionsprogramms kompetenter im Umgang mit ihrem Kind. <i>Diskussion:</i> Die Teilnahme am Elterntraining korrespondiert trotz positiver Bewertung durch die Eltern nicht mit einer höheren Symptomreduktion der Kinder im Posttest. Möglicherweise führt allein die Teilnahme des Kindes an der Präventionsmaßnahme zu höherem Kompetenzerleben bei allen Eltern. Die Überprüfung der langfristigen Wirksamkeit steht noch aus.
DOI: 10.17632/9d5vk26y29
title: Raw data for Estimation of Aerobic Capacity (VO2max) Using Non-Exercise Test among Malaysian Youth during Coronavirus disease-19 (COVID-19) Lockdown 08042022

description: Estimation of Aerobic Capacity (VO2max) Using Non-Exercise Test among Malaysian Youth during Coronavirus disease-19 (COVID-19) Lockdown 08042022
DOI: 10.17632/yd8bbfzdmc
title: Biculturals and Creativity

description: The dataset was used to test values affect the relation between self-construals / bicultural self and creativity; Culturally congruent values strenghten the link between self-construals and creativity. The dataset included self-construal, values, and creativity scale scores of a sample of university students in Turkey. The data were analyzed via SPSS v22 and Process macros (v3.5, Model 1, Hayes 2017). An output file displaying interaction results is also included.
DOI: 10.6084/m9.figshare.19242627.v3
title: Table S10 Widely-targeted metabolomic and lipidomic dataset used in the formal analysis.xlsx

description: <b>Background</b>Systemic immune inflammation is a key mediator in the progression coronary artery disease (CAD), concerning various metabolic and lipid changes. In this study, the relationship between the inflammatory index and metabolic profiling in patients with CAD was investigated to provide deep insights into metabolic disturbances related to inflammation.<b>Methods</b>Widely targeted plasma metabolomic and lipidomic profiling was performed in 1,234 patients with CAD. Laboratory circulating inflammatory markers were mainly used to define general systemic immune and low-grade inflammatory states. Multivariable-adjusted linear regression was adopted to assess the associations between 860 metabolites and 7 inflammatory markers. Least absolute shrinkage and selection operator (LASSO) logistic-based classifiers and multivariable logistic regression were applied to identify biomarkers of inflammatory states and develop models for discriminating an advanced inflammatory state.<b>Results</b>Multiple metabolites and lipid species were linearly associated with the seven inflammatory markers (<i>FDR</i>&lt;0.05). LASSO and multivariable-adjusted logistic regression analysis identified significant associations between 45 metabolites and systemic immune-inflammation index, 46 metabolites and neutrophil-lymphocyte ratio states, 32 metabolites and low-grade inflammation score, and 26 metabolites and high-sensitivity C-reactive protein states (<i>P</i>&lt;0.05). Glycerophospholipid metabolism and arginine and proline metabolism were determined as key altered metabolic pathways for systemic immune and low-grade inflammatory states. Predictive models based solely on metabolite combinations showed feasibility (AUC: 0.81 to 0.88) for discriminating the four parameters that represent inflammatory states and were successfully validated using a validation cohort. The inflammation-associated metabolite, namely, β-pseudouridine was related to carotid and coronary arteriosclerosis indicators (<i>P</i> &lt;0.05).<b>Conclusions</b>This study provides further information on the relationship between plasma metabolite profiles and inflammatory states represented by various inflammatory markers in CAD. These metabolic markers provide potential insights into pathological changes during CAD progression and may aid in the development of therapeutic targets.
DOI: 10.6084/m9.figshare.23899530.v1
title: Datasets

description: Source data for Soil carbon storage capacity of drylands under altered fire regimes