cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28238501
title: Global research trends on nanotechnology and colorectal cancer: a two-decade analysis

description: Colorectal cancer (CRC) remains a serious threat to humans worldwide. In this study, we used bibliometric analysis of the scientific literature to assess the trends and prospects of nanotechnology applications in CRC. We used the Web of Science Core Collection database to screen relevant publications on nanotechnology and CRC from 2004 to 2023 based on the inclusion criteria. Bibliometric analyses were performed on all selected publication and citation data. Visual analysis using VOSviewer and CiteSpace intuitively reflected the hotspots in this field. In total, 2040 publications on nanotechnology in CRC were identified for this two-decade analysis. China (443, 29.14%) and the USA (199, 13.09%) were the top two most productive countries, and Sichuan University was the most prolific institution. The most influential journal was the International Journal of Nanomedicine. The author with the most papers was Li L. “Nanoparticles,” “drug delivery,” and “CRC” were the most common keywords. Green synthesis and gold nanoparticles were peripheral, incompletely developed topics. This study provides a comprehensive overview of nanomaterials in CRC as clinical medicine, enriching the body of evidence in this field.
DOI: 10.6084/m9.figshare.28303520
title: EZH2 inhibition enhances the activity of Carboplatin in aggressive-variant prostate cancer cell lines

description: Aggressive Variant Prostate Cancers (AVPCs) are incurable malignancies. Platinum-based chemotherapies are used for the palliative treatment of AVPC. The Polycomb Repressive Complex 2 (PRC2) promotes prostate cancer progression <i>via</i> histone H3 Lysine 27 tri-methylation (H3K27me3). <i>EZH2</i> encodes the catalytic subunit of PRC2. A recently developed nucleosome capture technology (Nu.Q<sup>Ⓡ</sup>).measures H3K27me3 levels in biological fluids. EZH2 inhibitors (EZH2i) are being tested in clinical trials. We hypothesize that epigenetic reprogramming <i>via</i> EZH2i improves the efficacy of Carboplatin in AVPC and that EZH2i activity can be measured via both cellular- and cell-free nucleosomal H3K27me3 (cf-H3K27me3) levels. We studied the expression of PRC2 genes in clinical prostate cancer cohorts (bioinformatics). We determined the effect of EZH2i on cellular- and cf-H3K27me3 levels. We measured dose-dependent effects of Carboplatin with/without EZH2i on AVPC cell viability (IC<sub>50</sub>). We used RNA-Seq to study how EZH2i modulates gene expression in AVPC cells. PRC2 genes were significantly up-regulated in AVPC <i>vs</i> other prostate cancer types. EZH2i reduced both cellular and cf-H3K27me3 levels. EZH2i significantly reduced Carboplatin IC<sub>50</sub>. EZH2i reduced the expression of DNA repair genes and increased the expression of p53-dependent pro-apoptotic factors. EZH2i plus Carboplatin is a promising combination treatment for AVPC.
DOI: 10.6084/m9.figshare.28303520.v1
title: EZH2 inhibition enhances the activity of Carboplatin in aggressive-variant prostate cancer cell lines

description: Aggressive Variant Prostate Cancers (AVPCs) are incurable malignancies. Platinum-based chemotherapies are used for the palliative treatment of AVPC. The Polycomb Repressive Complex 2 (PRC2) promotes prostate cancer progression <i>via</i> histone H3 Lysine 27 tri-methylation (H3K27me3). <i>EZH2</i> encodes the catalytic subunit of PRC2. A recently developed nucleosome capture technology (Nu.Q<sup>Ⓡ</sup>).measures H3K27me3 levels in biological fluids. EZH2 inhibitors (EZH2i) are being tested in clinical trials. We hypothesize that epigenetic reprogramming <i>via</i> EZH2i improves the efficacy of Carboplatin in AVPC and that EZH2i activity can be measured via both cellular- and cell-free nucleosomal H3K27me3 (cf-H3K27me3) levels. We studied the expression of PRC2 genes in clinical prostate cancer cohorts (bioinformatics). We determined the effect of EZH2i on cellular- and cf-H3K27me3 levels. We measured dose-dependent effects of Carboplatin with/without EZH2i on AVPC cell viability (IC<sub>50</sub>). We used RNA-Seq to study how EZH2i modulates gene expression in AVPC cells. PRC2 genes were significantly up-regulated in AVPC <i>vs</i> other prostate cancer types. EZH2i reduced both cellular and cf-H3K27me3 levels. EZH2i significantly reduced Carboplatin IC<sub>50</sub>. EZH2i reduced the expression of DNA repair genes and increased the expression of p53-dependent pro-apoptotic factors. EZH2i plus Carboplatin is a promising combination treatment for AVPC.
DOI: 10.6084/m9.figshare.28077121
title: Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults

description: Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts. We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status. Among individuals with the <i>FKBP5</i> CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased <i>FKBP5</i> (CC genotype) methylation among immigrants. R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities. Hispanics/Latinos, the largest racial/ethnic minority group in the United States, face significant stressors and health challenges. Religion and spirituality are key sources of resilience, particularly for immigrants. However, the ways in which religion and spirituality influence genes related to health outcomes are not yet fully understood. In this study, we found that religion and spirituality impact a key gene in the body’s stress response system differently between immigrants and US-born individuals. We suggest that future research should explore how varying stressors and resilience factors affect these two groups, with the goal of improving health outcomes for all Hispanics/Latinos.
DOI: 10.6084/m9.figshare.28106682
title: Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations

description: Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations
DOI: 10.6084/m9.figshare.28238501.v1
title: Global research trends on nanotechnology and colorectal cancer: a two-decade analysis

description: Colorectal cancer (CRC) remains a serious threat to humans worldwide. In this study, we used bibliometric analysis of the scientific literature to assess the trends and prospects of nanotechnology applications in CRC. We used the Web of Science Core Collection database to screen relevant publications on nanotechnology and CRC from 2004 to 2023 based on the inclusion criteria. Bibliometric analyses were performed on all selected publication and citation data. Visual analysis using VOSviewer and CiteSpace intuitively reflected the hotspots in this field. In total, 2040 publications on nanotechnology in CRC were identified for this two-decade analysis. China (443, 29.14%) and the USA (199, 13.09%) were the top two most productive countries, and Sichuan University was the most prolific institution. The most influential journal was the International Journal of Nanomedicine. The author with the most papers was Li L. “Nanoparticles,” “drug delivery,” and “CRC” were the most common keywords. Green synthesis and gold nanoparticles were peripheral, incompletely developed topics. This study provides a comprehensive overview of nanomaterials in CRC as clinical medicine, enriching the body of evidence in this field.
DOI: 10.6084/m9.figshare.28106682.v1
title: Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations

description: Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations
DOI: 10.5281/zenodo.14841770
title: ISWFM v2.0: An updated three-dimensional MITgcm model of Internal solitary waves in the northern South China Sea

description: This repository contains all publicly available data and code required to run the Northern South China Sea (NSCS) model using the MITgcm ocean model (ISWFM-NSCS v2.0). The model accounts for background currents, horizontally inhomogeneous stratifications, and optimized turbulence parameters. Additionally, the repository includes model output data, such as temperature, velocity, and sea surface gradients at a specific timestep: 12:00 UTC, August 12, 2014.

>> Contact Information:Email: gongyk@scsio.ac.cnAffiliation: State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

>> Repository Structure:===================================================================1. Model Input Files (Model_Input_Files/)This folder contains all necessary input files for initializing and running the model.

>> Three-dimensional initial stratification:Stored in the input/ folder, named SCS_MRGRID3D_TSUV_T.3d (temperature) and SCS_MRGRID3D_TSUV_S.3d (Salinity, not shown).These files are derived from the HYCOM reanalysis dataset (HYbrid Coordinate Ocean Model) and integrated into the model grids to account for horizontally inhomogeneous conditions.

>> Velocity boundary conditions:Stored in the input/ folder with filenames such as SCS_MRGRID3D_TSUV_U.3d.North (zonal velocity at the north boundary) and SCS_MRGRID3D_TSUV_V.3d.South (meridional velocity at the south boundary).

>> Tidal boundary conditions:Stored in the input/ folder with filenames such as OB_East_u_Amp.bin (amplitude) and OB_East_u_Gph.bin (phase).Derived from the Oregon State University TOPEX/Poseidon Solution (TPXO8-atlas, 1/30° resolution) (Egbert & Erofeeva, 2002).

>> Bathymetry data:File: Luzon.topo.linear.3dSourced from the GEBCO global gridded bathymetry dataset (https://www.gebco.net/data_and_products/gridded_bathymetry_data).

>> Model source code:Stored in the code/ folder, containing all relevant scripts required for compiling the model.

===================================================================2. Model Output Files (Model_Output_Files/)This folder contains the results generated by the model.

>> Grid information:Available in grid.glob.nc, hFacC.glob.nc, and hFacS.glob.nc.

>> Simulation results (timestep: 12:00 UTC, August 12, 2014):Sea surface elevation: stateEta.0000064800.glob.ncTemperature: stateT.0000064800.glob.ncZonal velocity (U-component): stateU.0000064800.glob.ncMeridional velocity (V-component): V.0000064800.glob.nc
DOI: 10.5281/zenodo.14842090
title: ISWFM v2.0: An updated three-dimensional MITgcm model of Internal solitary waves in the northern South China Sea

description: This repository contains all publicly available code and data required to run the Northern South China Sea (NSCS) model using the MITgcm ocean model (ISWFM-NSCS v2.0). The model accounts for background currents, horizontally inhomogeneous stratifications, and optimized turbulence parameters. Additionally, the repository includes model output data, such as temperature, velocity, and sea surface gradients at a specific timestep: 12:00 UTC, August 12, 2014.

Please note that our model is primarily developed based on the MITgcm (MIT General Circulation Model), and its operation relies on the MITgcm framework. MITgcm is an open-source ocean model, and its code and documentation are publicly available on its official website (https://mitgcm.org/source-code/, last access: 10 February 2025).

>> Contact Information:Email: gongyk@scsio.ac.cnAffiliation: State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

>> Repository Structure:===================================================================1. Model Code Files (ISWFM_NSCS_v2.0_Code_Files/)This folder contains all necessary input files for initializing and running the model.

>> Three-dimensional initial stratification:Located in the input/ folder, named SCS_MRGRID3D_TSUV_T.3d (temperature).These files are derived from the HYCOM reanalysis dataset (HYbrid Coordinate Ocean Model) and integrated into the model grids to account for horizontally inhomogeneous conditions.

>> Velocity boundary conditions:Stored in the input/ folder with filenames such as SCS_MRGRID3D_TSUV_U.3d.North (zonal velocity at the north boundary) and SCS_MRGRID3D_TSUV_V.3d.South (meridional velocity at the south boundary).

>> Tidal boundary conditions:Stored in the input/ folder with filenames such as OB_East_u_Amp.bin (amplitude) and OB_East_u_Gph.bin (phase).Derived from the Oregon State University TOPEX/Poseidon Solution (TPXO8-atlas, 1/30° resolution) (Egbert & Erofeeva, 2002).

>> Bathymetry data:File: Luzon.topo.linear.3dSourced from the GEBCO global gridded bathymetry dataset (https://www.gebco.net/data_and_products/gridded_bathymetry_data).

>> Model source code:Stored in the code/ folder, containing all relevant scripts required for compiling the model.

===================================================================2. Model Data Files (ISWFM_NSCS_v2.0_Data_Files/)This folder contains the results generated by the model.

>> Grid information:Available in grid.glob.nc, hFacC.glob.nc, and hFacS.glob.nc.

>> Simulation results (timestep: 12:00 UTC, August 12, 2014):Sea surface elevation: stateEta.0000064800.glob.ncTemperature: stateT.0000064800.glob.ncZonal velocity (U-component): stateU.0000064800.glob.ncMeridional velocity (V-component): V.0000064800.glob.nc
DOI: 10.5281/zenodo.6792999
title: Three-dimensional MITgcm model of Internal solitary waves in the northern South China Sea

description: This repository contains all publicly available data and code required in the northern South China Sea model using the MITgcm ocean model, as well as model results, namely temperature, velocity and sea surface gradients at a specific moment (12:00 UTC 2014-Aug-12). Email: gongyk@scsio.ac.cn<br> Affiliation: State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. ===================================================================<br> Folder "Model_Input_Files": (1) Initial stratification condition files are saved in the "input" folder, which are named as "Temp.init" and "Salt.init". Note the files are derived from the WOA18 climatology dataset (World Ocean Atlas 2018) by spatially averaging the monthly output in August, resulting in horizontally-uniform conditions.<br> (2) Tidal boundary condition files are saved in the "input" folder, which are named in the form of "OB_East_u_Amp.bin" (amplitude) and "OB_East_u_Gph.bin" (phase). Note the files are originated from the Oregon State University TOPEX/Poseidon Solution (TPXO8-atlas data) with 1/30 deg resolution (Egbert and Erofeeva, 2002).<br> (3) Bathymetry data is named as "Luzon.topo.linear.3d", which is derived from the global gridded bathymetry dataset GEBCO (https://www.gebco.net/data_and_products/gridded_bathymetry_data).<br> (4) Relevant code is saved in the folder "code" for compiling the model. ===================================================================<br> Folder "Model_Output_Files": (1) Grid information can be found in "grid.glob.nc", "hFacC.glob.nc" and "hFacS.glob.nc".<br> (2) Three-dimensional (x-y-z) matrixes of sea surface elevations, temperature, zonal and meridional velocity at 12:00 UTC 2014-Aug-12 are saved as "stateEta.0000064800.glob.nc", "stateT.0000064800.glob.nc", "stateU.0000064800.glob.nc", and "stateV.0000064800.glob.nc".<br> (3) Single station output file in the vicinity of the Dongsha Atoll (117<sup>o</sup>44.7’E, 20<sup>o</sup>44.2’N) with a sampling rate of 1 min is named as "ST_DS_Params.nc", including temperature, zonal, meridional and vertical velocity. <br>
DOI: 10.5281/zenodo.11198345
title: Dataset: UL and HCP multiscale weighted human brain connectomes

description: This repository contains the multi-scale weighted connectomes (edge list with fiber density) computed using diffusion weighted images from 2 different datasets. The first dataset contains a subsample of 44 subjects extracted from the test-retest dataset included in the Human Connectome Project (HCP). The second dataset is compound by 40 healty controls selected from Lausanne psychosis cohort (UL).  The age of the subjects belonging to the HCP dataset ranges between 22 and 35 years old while the mean age for the subjects included in the UL dataset is around 25 years old.

 

Files ending in '_nodes.txt' contain the structure code, the name and the center of mass coordinate for each gray matter structure.

Files ending in '_weight_edgelist.txt' contain the structure code, the name and the center of mass coordinate for each gray matter structure.
DOI: 10.5281/zenodo.11198346
title: Dataset: Optimal navigability of weighted human brain connectomes in physical space

description: Dataset used in the publication "Optimal navigability of weighted human brain connectomes in physical space"

This repository contains the multi-scale weighted connectomes (edge list with fiber density) computed using diffusion weighted images from 2 different datasets. The first dataset contains a subsample of 44 subjects extracted from the test-retest dataset included in the Human Connectome Project (HCP). The second dataset is compound by 40 healty controls selected from Lausanne psychosis cohort (UL).  The age of the subjects belonging to the HCP dataset ranges between 22 and 35 years old while the mean age for the subjects included in the UL dataset is around 25 years old.

 

Files ending in '_nodes.txt' contain the structure code, the name and the center of mass coordinate for each gray matter structure.

Files ending in '_weight_edgelist.txt' contain the structure code, the name and the center of mass coordinate for each gray matter structure.
DOI: 10.5281/zenodo.14017270
title: Dataset: UL and HCP multiscale weighted human brain connectomes

description: This repository contains the multi-scale weighted connectomes (edge list with fiber density) computed using diffusion weighted images from 2 different datasets. The first dataset contains a subsample of 44 subjects extracted from the test-retest dataset included in the Human Connectome Project (HCP). The second dataset is compound by 40 healty controls selected from Lausanne psychosis cohort (UL).  The age of the subjects belonging to the HCP dataset ranges between 22 and 35 years old while the mean age for the subjects included in the UL dataset is around 25 years old.

 

Files ending in '_nodes.txt' contain the structure code, the name and the center of mass coordinate for each gray matter structure.

Files ending in '_weight_edgelist.txt' contain the structure code, the name and the center of mass coordinate for each gray matter structure.
DOI: 10.5281/zenodo.14847494
title: ҚОРАҚАЛПОҒИСТОНДА ҚОРАМОЛЛАРДА ФАСЦИОЛЁЗ КАСАЛЛИГИ: ЭПИЗООТОЛОГИК ХУСУСИЯТЛАР, ПАТОЛОГИЯ ВА ТАШХИС УСУЛЛАРИ БЎЙИЧА КОМПЛЕКС ТАДҚИҚОТЛАР
DOI: 10.5281/zenodo.14847495
title: ҚОРАҚАЛПОҒИСТОНДА ҚОРАМОЛЛАРДА ФАСЦИОЛЁЗ КАСАЛЛИГИ: ЭПИЗООТОЛОГИК ХУСУСИЯТЛАР, ПАТОЛОГИЯ ВА ТАШХИС УСУЛЛАРИ БЎЙИЧА КОМПЛЕКС ТАДҚИҚОТЛАР
DOI: 10.21227/8kp7-p656
title: Multi-modal PV defect dataset

description: We present a small novel multi-modal image dataset collected from a commercial Floating Photovoltaic (FPV) installation, combining thermal imaging with color information through an innovative channel-wise fusion approach.The dataset consists of 10 synchronized image pairs captured at 2.5m altitude under clear weather conditions, where the Red channel contains calibrated thermal data, while the Green and Blue channels incorporate the luminance (Y) and chrominance (U) components, respectively, derived from YUV-transformed RGB images.The dataset encompasses seven distinct classes of PV module conditions: Hotspots, Bird Droppings, Dirt Accumulation, Heated Junction Boxes, intact PV Modules, Residual Damage, and compound Hotspots caused by Bird Droppings or Dirt. This unique combination enables simultaneous analysis of thermal signatures and visual features within a single image structure, facilitating research in automated inspection and fault detection in floating solar installations.Each image is accompanied by detailed metadata including capture conditions, calibration parameters, and ground truth annotations for all seven classes. The dataset's structure allows for straightforward integration with existing computer vision frameworks while providing new opportunities for developing algorithms specifically tailored to FPV installation monitoring and maintenance. This resource addresses the growing need for specialized multi-modal datasets in the renewable energy sector and supports research in thermal-visual fusion applications for solar installation inspection.
DOI: 10.6073/pasta/4205c325bd136dc264c83ba71b9c1a5b
title: High-frequency, hourly, and daily measurements from Lake Vanda Meteorological Station (VAAM), McMurdo Dry Valleys, Antarctica (1994-2024, ongoing)

description: As part of the McMurdo Dry Valleys Long-Term Ecological Research program, a spatially distributed, long-term climate monitoring network was established across the McMurdo Dry Valleys region of Antarctica, consisting of fourteen research-grade weather stations that continuously measure a standard suite of environmental parameters. Ecosystem processes in this region are strongly regulated by climatic drivers that exhibit high variability across both time and space, making accurate measurement of environmental variables at high temporal and spatial resolution essential to understanding the biophysical dynamics of this polar desert ecosystem. This data package includes measurements from the Lake Vanda Meteorological Station (VAAM), which was established in 1994 on the eastern shore of Lake Vanda in Wright Valley, McMurdo Dry Valleys, Antarctica. Parameters include air temperature, relative humidity, photosynthetically active radiation, incoming and outgoing shortwave radiation, wind speed and direction, surface distance, as well as soil bulk electrical conductivity, dielectric permittivity, temperature, and volumetric water content. Data are provided at high frequency (typically 15-minute intervals), along with hourly and daily summaries. Users should note that summary statistics may be affected by periods of missing data. Since there is no universally accepted standard for handling gaps in time-series data, users are encouraged to work with the high-frequency data and establish their own criteria for acceptable data completeness to minimize any potential bias.
DOI: 10.5281/zenodo.14847499
title: ENRICHMENT OF THE NUTRITIONAL COMPOSITION OF PREGNANT WOMEN WITH HEPATITIS WITH BIOLOGICALLY ACTIVE SUBSTANCES
DOI: 10.5281/zenodo.14847500
title: ENRICHMENT OF THE NUTRITIONAL COMPOSITION OF PREGNANT WOMEN WITH HEPATITIS WITH BIOLOGICALLY ACTIVE SUBSTANCES
DOI: 10.5281/zenodo.14846531
title: SS3DPacificSyn

description: 3D surface-wave SOLA tomography model of Vsv in the Pacific upper mantle in a synthetic setup.
DOI: 10.5281/zenodo.14846532
title: SS3DPacificSyn

description: 3D surface-wave SOLA tomography model of Vsv in the Pacific upper mantle in a synthetic setup.