cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27159360
title: Supplementary Material for: Long-term outcome of a multicenter prospective study on efficacy and safety of high-dose Stereotactic Body Radiation Therapy ≥ 48 hour-interfraction interval for ≤ 5 cm hepatocellular carcinoma

description: Introduction: The goal of this study was to evaluate the efficacy and safety of high-dose stereotactic body radiation therapy (SBRT) with an extended (48 hours or more) interfraction interval for hepatocellular carcinoma (HCC) ≤5 cm in size after incomplete response to transarterial chemoembolization (TACE).
Methods: This multicenter prospective study included 54 patients with inoperable HCC of ≤5 cm size between July 2012 and June 2015. A total SBRT dose of 60 Gy in 3 fractions was administered within 14 days with ≥48 hours interfraction interval to patients who showed an incomplete response after 1–5 sessions of TACE. Treatment responses were defined according to the modified Response Evaluation Criteria for Solid Tumors. Toxicities were evaluated using the Common Terminology Criteria for Adverse Events version 4.0.
Results: Forty-eight patients were evaluated with a median follow-up period of 66 months (range, 2–126 months). The median tumor size was 2.0 cm (range, 1.0–4.5 cm), and most patients (87.5%) had a single lesion. The 1-, 2-, and 5-year local control (LC) rates were 100%, 94.8%, and 90.7%, respectively. The 1-, 2-, and 5-year progression-free survival (PFS) rates were 63.4%, 56.9%, and 24.9%, respectively. The 1-, 2-, and 5-year overall survival (OS) rates were 95.6%, 90.9%, and 76.5%, respectively. None of the patients experienced grade 3+ gastrointestinal toxicity, while one patient developed non-classic radiation-induced liver disease 2 months after SBRT.
Conclusion: High-dose SBRT with a ≥48-hour interfraction interval after incomplete response to TACE is effective for HCC ≤5 cm in size as evidenced by the high rates of LC and OS and acceptable treatment-related toxicity.
DOI: 10.6084/m9.figshare.27169383
title: Supplementary Material for: Uric acid levels and cardiovascular and cerebrovascular diseases: a Mendelian randomization study

description: Introduction: The relationship between uric acid (UA) levels and cardiovascular and cerebrovascular diseases (CCVD) is controversial. A two-sample Mendelian randomization (MR) study was conducted to explore the causal effects of UA levels on CCVD. Methods: Genetic variants strongly associated with UA levels were selected as instrumental variables from the Genome-Wide Association Study (GWAS) dataset. The GWAS data, sourced from the Global Urate Genetics Consortium (GUGC), comprised a sample size of 110,347 individuals. The selected CCVD outcomes included stroke, coronary artery disease (CAD), as well as atrial fibrillation and flutter. The primary analytical approach employed the inverse-variance weighted (IVW) method, supplemented by MR-Egger and weighted median as complementary methods. Sensitivity analysis was performed to test heterogeneity and pleiotropy. Results: The MR analysis results indicated a causal association between UA levels and stroke (OR: 1.002; 95% CI: 1.000-1.003; p = 0.036), CAD (OR: 1.118; 95% CI: 1.044-1.197; p = 0.001), as well as atrial fibrillation and flutter (OR: 1.141; 95% CI: 1.037- 1.256; p = 0.007). The results of MR-Egger and weighted median methods confirmed the direction of the IVW results, enhancing the robustness of the findings. No significant anomalies were detected in the sensitivity analysis. Conclusion: The MR study suggests that UA levels exert causal effects on stroke, CAD, as well as atrial fibrillation and flutter.
DOI: 10.15468/dl.1mklkl
title: Occurrence Download

description: A dataset containing 64 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pseudoryzomys simplex (Winge, 1887)"
 ]
}

 The dataset includes 64 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004484-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.1mwjqw
title: Occurrence Download

description: A dataset containing 42 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Galea musteloides leucoblephara (Burmeister, 1861)"
 ]
}

 The dataset includes 42 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004414-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2zn1xv
title: Occurrence Download

description: A dataset containing 374 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tupinambis merianae Duméril & Bibron, 1839"
 ]
}

 The dataset includes 374 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004535-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.a6z1c7
title: Occurrence Download

description: A dataset containing 523 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Necromys obscurus (Waterhouse, 1837)"
 ]
}

 The dataset includes 523 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004479-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dj9qww
title: Occurrence Download

description: A dataset containing 106 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lestodelphys halli (Thomas, 1921)"
 ]
}

 The dataset includes 106 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004499-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m2pys9
title: Occurrence Download

description: A dataset containing 863 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Holochilus brasiliensis (Desmarest, 1819)"
 ]
}

 The dataset includes 863 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004460-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mece9s
title: Occurrence Download

description: A dataset containing 2218 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Calomys musculinus (Thomas, 1913)"
 ]
}

 The dataset includes 2218 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004444-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.njdg0k
title: Occurrence Download

description: A dataset containing 399 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ctenomys talarum Thomas, 1898"
 ]
}

 The dataset includes 399 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004410-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.os1ser
title: Occurrence Download

description: A dataset containing 13550 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Calomys Waterhouse, 1837"
 ]
}

 The dataset includes 13550 records from 52 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004454-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sxkpwd
title: Occurrence Download

description: A dataset containing 453 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chaetophractus villosus (Desmarest, 1804)"
 ]
}

 The dataset includes 453 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004488-150528172251762/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15787/vtt1/59luu1
title: Identifying the Association Between Level of Safety of the Events and Driver Characteristics: A Market Basket Analysis

description: Project Description This study identifies the association between the level of safety of the events and the driver characteristic under the different daylight, weather and road surface condition using Market Basket Analysis Data Request Scope The dataset contains all the crash, near-crash and baseline events. Data Specification The VTTI provided following tables and questionnaires Post Crash Interview Data Event Detail Table Data Driver Demographic Questionnaire Data Driving History Questionnaire Data Driving Knowledge Survey Data Visual and Cognitive Tests Data Conner's Continuous Performance Test Data Clock Drawing Assessment Data Physical Strength Tests Data Barkley's ADHD Screening Test Data Risk Perception Questionnaire Data Risk Taking Questionnaire Data Sensation Seeking Scale Survey Data Driver Behavior Questionnaire Data Medical Conditions Medications Data Sleep Habits Questionnaire Data Medical Conditions and Medications - Exit Data Driver Exit Interview Data
DOI: 10.18128/d010.v8.0
title: IPUMS USA: Version 8.0

description: IPUMS USA contains harmonized census and American Community Survey (ACS) data from 1790 to the present. For the period 1850 to 1940, IPUMS includes 100% of individuals in the decennial censuses. For the period 1950 to 2010, we have public use samples of decennial censuses. For the period since 2000, IPUMS provides annual ACS public use samples. The available information in the censuses and ACS varies by year, but generally includes basic housing data (type of housing, household appliances, and housing characteristics), demographic data (age, race, sex, marital status, and relationship to the head of household), economic data (occupation, industry, income, work status), and other individual characteristics (migration, disability, veteran status). For the period 1790 to 1840, IPUMS includes household level records for 100% of households. IPUMS USA is available through an online data access system free of charge to registered users at usa.ipums.org.
DOI: 10.5281/zenodo.4015325
title: SNDATA_ROOT for SNANA software

description: Environment for the Supernova Analysis software package (https://github.com/RickKessler/SNANA). This environment Includes public light curve data sets, filter transmissions, primary SEDs, calibration files, models for SNIa & CC, cadence and host-galaxy libraries for simulations, etc ...
DOI: 10.5281/zenodo.7075507
title: Nucl.eye.D

description: Here you can find all datasets, scripts and trained models related to the Nucl.eye.D workflow presented in the publication - "Advanced image analysis methods for automated segmentation of subnuclear chromatin domains " ! The folder nucleyed.zip contains: - trained models (&gt;Output&gt;models) <br> - training data-set (&gt;Input)<br> - all images (&gt;Input) The folder SupplementalMacros.zip contains all supplemental macro used for the analysis. The file : The_Nucl_Eye_D.ipynb can be directly used following the noted instructions : - Download The_Nucl_Eye_D.ipynb <br> - upload it to your Google Drive <br> - Open it with Google Colaboratory (Or if not already installed : Open with -&gt; More applications -&gt; Google Colaboratory -&gt; Install) (We recommend using Chrome browser) <br> For question about the script contact : <em>nucl.eye.d@gmail.com</em> <br> Enjoy using Nucl.eye.D !
DOI: 10.5518/300
title: in-vitro evaluation of the biomechanical performance of nucleus augmentation (quasi static axial compression)

description: Combined experimental and computational study of mechanical behaviour of bovine intervertebral disc. Experimental data: microCT images and mechanical data of axially loaded samples of bovine tail osteodiscs (N=24); Computational data: FE model of samples using experimental data (N=18) + sensitivity study; Results data: stress and strains values associated with the experimental and computational data + tri-linear fit.
DOI: 10.6084/m9.figshare.25102391
title: Supplementary Material for: Pain/Stress, Mitochondrial Dysfunction and Neurodevelopment in Preterm Infants

description: Introduction Preterm infants experience tremendous early life pain/stress during their neonatal intensive care unit (NICU) hospitalization, which impacts their neurodevelopmental outcomes. Mitochondrial function/dysfunction may interface between perinatal stress events and neurodevelopment. Nevertheless, the specific proteins or pathways linking mitochondrial functions to pain-induced neurodevelopmental outcomes in infants are remain unidentified. Our study aims to investigate the associations among pain/stress, proteins associated with mitochondrial function/dysfunction, and neurobehavioral responses in preterm infants. 
Methods We conducted a prospective cohort study, enrolling 33 preterm infants between September 2017 and July 2022 at two affiliated NICUs located in Hartford and Farmington, CT. NICU Network Neurobehavioral Scale (NNNS) datasets were evaluated to explore potential association with neurobehavioral outcomes. The daily pain/stress experienced by infant’s during their NICU stay was documented. At 36-38 weeks post-menstrual age (PMA), neurobehavioral outcomes were evaluated using the NNNS and buccal swabs were collected for further analysis. Mass spectrometry-based proteomics was conducted on epithelial cells obtained from buccal swabs to evaluate protein expression level. Lasso statistical methods were conducted to study the association between protein abundance and infants’ NNNS summary scores. Multiple linear regression and Gene Ontology (GO) enrichment analyses were performed to examine how clinical characteristics and neurodevelopmental outcomes may be associated with protein levels and underlying molecular pathways. 
Results During NICU hospitalization, preterm premature rupture of membrane (PPROM) were negatively associated with neurobehavioral outcomes. The protein functions including leptin receptor binding activity, glutathione disulfide oxidoreductase activity and response to oxidative stress, lipid metabolism, phosphate and proton transmembrane transporter activity were negatively associated with neurobehavioral outcomes, in the contrast, cytoskeletal regulation, epithelial barrier and protection function were found to be associated with the optimal neurodevelopmental outcomes. In addition, mitochondrial function associated proteins including SPRR2A, PAIP1, S100A3, MT-CO2, PiC, GLRX, PHB2, and BNIPL-2 demonstrated positive association with favorable neurodevelopmental outcomes, while proteins of ABLIM1, UNC45A, Keratins, MUC1, and CYB5B showed positive association with adverse neurodevelopmental outcomes. 
Conclusion Mitochondrial function-related proteins were observed to be associated with early life pain/stress and neurodevelopmental outcomes in infants. Large-scale studies with longitudinal datasets are warranted. Buccal proteins could be used to predict potential neurobehavioral outcomes.
DOI: 10.6084/m9.figshare.26002471
title: Supplementary Material for: A novel method to localize patency capsule by ileo-colonoscopy facilitates endoscopic assessment of the small and large intestine in patients with Crohn’s disease

description: Introduction: Patients with Crohn’s disease (CD) require an assessment of small bowel lesions, while difficulties exist in performing small intestinal examinations especially in small-sized medical offices. Small bowel capsule endoscopy (SBCE) is handy and can be performed in most clinical settings. The only drawback of SBCE is a requirement of patency testing prior to the exam because it sometimes requires CT scanning to localize the ingested patency capsule (PC), which may be a substantial burden for the patient. We have developed a novel PC detection system named PICS (Patency capsule, Ileo-Colonoscopy and Small bowel capsule endoscopy) method by which we can avoid CT scanning. In the PICS method, Ileo-Colonoscopy (ICS) is performed after 30 to 33 hours of PC ingestion and the PC can be localized by ICS in patients who have not excreted the PC, and the entire intestine can be examined in combination with subsequent SBCE without additional bowel preparation. The aim of this study was to assess the usefulness and safety of the PICS method for CD patients.
Methods: CD patients who underwent PICS method from April 2021 to March 2023 were reviewed for clinical data, outcome of PICS method including the rates of PC detection by ICS, the number of patients underwent SBCE, and adverse events. Lewis score was used to assess SBCE results. 
Results: The PICS method was performed in 54 patients. The median age of patients was 28.5 years old and 64.8% of them were ileo-colic type. The median disease duration was 10.5 months and 24.1% had history of small bowel resection. Five cases (9.3%) confirmed gastrointestinal patency by ICS and none of the cases required CT scanning. One patient who could not be confirmed patency by ICS, and the other patient who excreted PC but was found ileal stenosis by ICS did not undergo SBCE. Remaining 52 patients received SBCE and the median Lewis score of them was 0 (IQR 0, 450). There were no adverse events including small bowel obstruction by PC and SBCE retention in this series. 
Conclusion: The PICS method is not only feasible and safe but also convenient to assess disease extent in patients with CD. By localizing PC with ICS, additional CT scanning could be unnecessary for SBCE, which benefits both physicians and CD patients.
DOI: 10.6084/m9.figshare.26838841.v2
title: Outcome measures for older adults in rehabilitation wards: A systematic review

description: The paper is a systematic review examining outcome measures used for older adults in rehabilitation wards, focusing on the effectiveness of various assessment tools for treatment planning and patient management.
DOI: 10.6084/m9.figshare.27141378
title: Supplementary Material for: Efficacy and safety of FGF21 analogues for metabolic dysfunction-associated steatohepatitis: A systematic review and meta-analysis

description: Introduction: Fibroblast growth factor 21 (FGF21) analogues may benefit patients with metabolic dysfunction-associated steatohepatitis (MASH). We aimed to compare the efficacy and safety of FGF21 analogues versus placebo for treating patients with MASH in randomized controlled trials (RCTs).
Methods: We searched PubMed, Embase, and the Cochrane Library. Primary outcomes were fibrosis improvement ≥1 stage without worsening of MASH and MASH resolution without worsening of fibrosis. Secondary outcomes were relative reduction ≥30% of the hepatic fat fraction (HFF) measured by magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) and adverse events (AEs).
Results: We included 7 RCTs (886 patients). FGF21 analogues had a higher probability of fibrosis improvement ≥1 stage without worsening of MASH (RR 1.54; 95%CI 1.07, 2.22), MASH resolution without worsening of fibrosis (RR 3.31; 95%CI 1.80, 6.06), and reduction ≥30% in the HFF by MRI-PDFF (RR 3.03; 95%CI 2.12, 4.33) than placebo, without significant difference in the risk of AEs. Subgroup analyses by the stage of fibrosis showed FGF21 analogues improved fibrosis only among patients with fibrosis stages F1-F3.
Conclusion: FGF21 analogues appear to be an effective and safe treatment option for patients with MASH, although the impact on fibrosis improvement may be limited to non-cirrhotic patients.
DOI: 10.6084/m9.figshare.27141591
title: Supplementary Material for: Efficacy and safety of autologous stem cell transplantation in first-line treatment and at relapse in elderly patients with multiple myeloma

description: Introduction
Although recent data suggest that Melphalan high-dose therapy followed by autologous stem cell transplantation (HDT/ASCT) is safe and effective in eligible multiple myeloma (MM) patients up to the age of 75 years, its value in elderly MM patients is still controversially discussed. 
Methods
We retrospectively analyzed 607 MM patients ≥ 60 years old, who were admitted to our institution for first-line or salvage HDT/ASCT between January 2007 and October 2018. We assigned them to three groups according to age at HDT/ASCT: 60-64 years (S1), 65-69 years (S2) and ≥ 70 years (S3). We compared progression-free and overall survival, duration of hospitalization, complications, transfers to intermediate or intensive care unit, readmissions after discharge and deaths within 100 days after HDT/ASCT between these groups. 
Results
Age did not impact progression-free and overall survival after first-line and salvage HDT/ASCT. Patients ≥ 70 years old at first HDT/ASCT had a longer hospitalization compared to patients 60-64 years old, however, the difference in the length of hospitalization was only marginal. Rates of febrile neutropenia, mucositis, transfers to intermediate or intensive care unit, readmissions after discharge and deaths within 100 days after HDT/ASCT were similar in the three age groups of patients receiving first or salvage HDT/ASCT. Patients with a Charlson Comorbidity Index ≥ 2 receiving first HDT/ASCT had a higher risk for a transfer to intermediate or intensive care unit.
Conclusion
Our analysis shows that HDT/ASCT is safe and effective in eligible elderly MM patients in first-line treatment and at relapse. A careful patient selection according to biological rather than chronological age is of crucial importance.
DOI: 10.6084/m9.figshare.27159084
title: Supplementary Material for: The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study

description: Introduction
The definition of CKD is broad, which neglects the heterogeneity of risk across primary renal diseases.

Methods 
The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD is an ongoing UK, prospective multicentre cohort study of 2996 adults with an eGFR of 15–59 mL/min/1.73 m2 or eGFR ≥60 mL/min/1.73 m2 with a uACR &gt;30 mg/mmol. Outcomes and predictive performance of eGFR and uACR were subcategorized by ERA-EDTA primary renal diagnosis (PRD) codes. 

Results 
2638 participants were included, with baseline median eGFR of 33.5ml/min/1.73m2 and uACR 29.8 mg/mmol. Over a median 49.2 months follow-up, 630 (23.9%) experienced kidney failure (KF), and 352 (13.3%) died before KF, the median eGFR slope was -1.97 ml/min/1.73m2/year. There were significant differences in risk across the PRD, persisting after adjustment for age, sex, baseline eGFR and modifiable risk factors (Blood pressure, HbA1c and renin-angiotensin-aldosterone system inhibitors (RAASi). Diabetic kidney disease, glomerulonephritis and familial/hereditary nephropathy were associated with the greatest risk, while tubulointerstitial disease and vasculitis carried a low risk of KF. eGFR had good predictive accuracy across all PRD. However, the addition of uACR showed variable benefit, depending on the PRD. The largest benefit was seen in vasculitis, renal vascular, and DKD groups, but uACR added no predictive value to the familial/hereditary group. 

Conclusion 
Significant differences in the risk of kidney related outcomes occurred across the various primary renal diagnoses persisting after adjustment for age, sex, baseline eGFR and modifiable risk factors. Albuminuria's discriminatory ability as a biomarker of progression varies by diagnosis. CKD care should, therefore, take a personalized approach that always considers the primary renal diagnosis.