cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22828132.v1
title: Effect of experimental bleaching gels with polymers Natrosol and Aristoflex on the enamel surface properties

description: Abstract Natrosol and Aristoflex® AVC polymers are widely applied in the cosmetic industry and have recently been applied as a thickener option in the composition of dental bleaching gels, with the purpose to reduce the adverse effects on enamel mineral components. The aim of this study was to evaluate the color variation (ΔE* ab, ΔE00, ∆WID), surface roughness (Ra), and mineral content quantification (Raman Spectroscopy) of dental enamel after bleaching treatment with experimental gel-based on 10% carbamide peroxide (CP), containing Carbopol, Natrosol, and Aristoflex® AVC. Sixty bovine teeth were randomly divided into 6 groups (n=10): Negative Control (NC) - no treatment; Positive Control (PC) - Whiteness Perfect 10% - FGM; CP with Carbopol (CPc); CP with Natrosol (CPn); CP with Aristoflex® AVC (CPa); NCP - no thickener. Data were analyzed, and generalized linear models (∆WID -T0 x T1) were used for repeated measurements in time for Ra and with a study factor for ΔE* ab and ΔE00. For the evaluation of the mineral content, data were submitted to one-way ANOVA and Tukey tests. For enamel topographic surface analysis the Scanning Electron Microscope (SEM) was performed. A significance level of 5% was considered. ΔE* ab and ΔE00 were significantly higher for CPc, CPn, CPa, and NCP groups. (∆WID) showed a significantly lower mean than the other groups for NC in T1. After bleaching (4-hour daily application for 14 days), Ra was higher in the CPc, CPn, and PC groups. For CPa, Ra was not altered. No significant difference was found in the quantification of mineral content. CPa preserved the surface smoothness more effectively. Aristoflex® AVC is a viable option for application as a thickener in dental bleaching gels, presenting satisfactory performance, and maintaining the whitening efficacy of the gel, with the advantage of preserving the surface roughness of tooth enamel without significant loss of mineral content.
DOI: 10.6084/m9.figshare.22714105
title: Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Reveals New Gating Insights

description: This file contains all graphed data included in main manuscript figures and a table of all cloning details for constructs used in these experiments.
DOI: 10.6084/m9.figshare.22572715.v1
title: A rapid theta network mechanism for flexible information encoding

description: Source data for figures 1b-c, 2a, 2c, 3a-b, 3e, 4a, 5a-c, 5f, 6a, and 6c
DOI: 10.6084/m9.figshare.22572715
title: A rapid theta network mechanism for flexible information encoding

description: Source data for figures 1b-c, 2a, 2c, 3a-b, 3e, 4a, 5a-c, 5f, 6a, and 6c
DOI: 10.6084/m9.figshare.22982132
title: Morphological and yield responses of 'BRS Vitória' grapevines subjected to bio-fertigation with aquaculture wastewater

description: Abstract The objective of this work was to evaluate the agronomic responses of 'BRS Vitória' grapevines under bio-fertigation with and without conventional soil fertilizer. A completely randomized design was used, with three treatments and 18 replicates. The treatments were: CFI, conventional soil fertilizer and irrigation; BF+CF, bio-fertigation and conventional fertilizer; and BF, only bio-fertigation. The following variables were evaluated: graft and rootstock diameters; plant growth; number of lateral buds; root, leaf, petiole, and gem starch contents; bunch number per plant, length, circumference, and fresh weight; berry number per bunch, length, diameter, fresh weight, soluble solid contents, titratable acidity, and pH; yield; and leaf macro- and micronutrient contents. From 100 to 150 days after transplanting (DAT), rootstock and graft diameters were similar, increasing from 250 to 300 DAT in the CFI treatment. The highest root starch content was 7.19% in BF at 150 DAT and 37.35% in BF+CF at 300 DAT. The plants in BF+CF showed the best results for bunch number per plant and fresh weight, resulting in a fruit yield 22% higher than that obtained in the other treatments. 'BRS-Vitória' grapevines show a satisfactory agronomic performance when bio-fertigated.
DOI: 10.6084/m9.figshare.22982132.v1
title: Morphological and yield responses of 'BRS Vitória' grapevines subjected to bio-fertigation with aquaculture wastewater

description: Abstract The objective of this work was to evaluate the agronomic responses of 'BRS Vitória' grapevines under bio-fertigation with and without conventional soil fertilizer. A completely randomized design was used, with three treatments and 18 replicates. The treatments were: CFI, conventional soil fertilizer and irrigation; BF+CF, bio-fertigation and conventional fertilizer; and BF, only bio-fertigation. The following variables were evaluated: graft and rootstock diameters; plant growth; number of lateral buds; root, leaf, petiole, and gem starch contents; bunch number per plant, length, circumference, and fresh weight; berry number per bunch, length, diameter, fresh weight, soluble solid contents, titratable acidity, and pH; yield; and leaf macro- and micronutrient contents. From 100 to 150 days after transplanting (DAT), rootstock and graft diameters were similar, increasing from 250 to 300 DAT in the CFI treatment. The highest root starch content was 7.19% in BF at 150 DAT and 37.35% in BF+CF at 300 DAT. The plants in BF+CF showed the best results for bunch number per plant and fresh weight, resulting in a fruit yield 22% higher than that obtained in the other treatments. 'BRS-Vitória' grapevines show a satisfactory agronomic performance when bio-fertigated.
DOI: 10.6084/m9.figshare.22721032
title: Superior ferroelectricity and nonlinear optical response in a hybrid germanium iodide hexagonal perovskite

description: Data for figures in the manuscript and supplement
DOI: 10.6084/m9.figshare.22982141
title: Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter

description: Abstract Background Flexibility is crucial to the harmonious execution of joint movements. While skeletal muscle dysfunction in patients with HTLV-1 can interfere with mobility, it is unclear whether these patients experience reduced flexibility. Objective To evaluate the differences in flexibility between HTLV-1-infected individuals with and without myelopathy compared with uninfected controls. We also investigated whether age, sex, body mass index (BMI), physical activity level, or lower back pain influence flexibility in HTLV-1-infected individuals. Methods The sample consisted of 56 adults, of which 15 did not have HTLV-1, 15 had HTLV-1 without myelopathy, and 26 had TSP/HAM. Their flexibility was assessed using the sit-and-reach test and a pendulum fleximeter. Results No differences in flexibility were observed between the groups with and without myelopathy and controls without HTLV-1 infection using the sit-and-reach test. The pendulum fleximeter results of individuals with TSP/HAM presented the lowest flexibility among the groups with respect to trunk flexion, hip flexion and extension, knee flexion, and ankle dorsiflexion, even after adjusting for age, sex, BMI, level of physical activity, and lower back pain using multiple linear regression models. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced flexibility in movements: knee flexion, dorsiflexion, and ankle plantar flexion. Conclusions Individuals with TSP/HAM demonstrated reduced flexibility in most of the movements evaluated by the pendulum fleximeter. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced knee and ankle flexibility, potentially representing a marker of myelopathic development.
DOI: 10.6084/m9.figshare.22982141.v1
title: Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter

description: Abstract Background Flexibility is crucial to the harmonious execution of joint movements. While skeletal muscle dysfunction in patients with HTLV-1 can interfere with mobility, it is unclear whether these patients experience reduced flexibility. Objective To evaluate the differences in flexibility between HTLV-1-infected individuals with and without myelopathy compared with uninfected controls. We also investigated whether age, sex, body mass index (BMI), physical activity level, or lower back pain influence flexibility in HTLV-1-infected individuals. Methods The sample consisted of 56 adults, of which 15 did not have HTLV-1, 15 had HTLV-1 without myelopathy, and 26 had TSP/HAM. Their flexibility was assessed using the sit-and-reach test and a pendulum fleximeter. Results No differences in flexibility were observed between the groups with and without myelopathy and controls without HTLV-1 infection using the sit-and-reach test. The pendulum fleximeter results of individuals with TSP/HAM presented the lowest flexibility among the groups with respect to trunk flexion, hip flexion and extension, knee flexion, and ankle dorsiflexion, even after adjusting for age, sex, BMI, level of physical activity, and lower back pain using multiple linear regression models. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced flexibility in movements: knee flexion, dorsiflexion, and ankle plantar flexion. Conclusions Individuals with TSP/HAM demonstrated reduced flexibility in most of the movements evaluated by the pendulum fleximeter. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced knee and ankle flexibility, potentially representing a marker of myelopathic development.
DOI: 10.6084/m9.figshare.22982140
title: PHYSICAL EDUCATION, FEMNITIES AND UNIFORMS. THE CASE OF THE DEPARTAMENTO DE CULTURA FÍSICA (1929-1946) OF THE UNIVERSIDAD NACIONAL DE LA PLATA (ARGENTINE)

description: ABSTRACT: We investigate the construction of femininities from the use of uniforms for Physical Education classes. For this, we base ourselves on the case of the Department of Physical Culture, an institution that existed between 1929 and 1946, of the National University of La Plata (Buenos Aires, Argentina). We wonder about how and why the Physical Education uniforms contributed to gendering and sexualizing the bodies of female students. We build three periods from the mandatory establishment of female uniforms for Gymnastics classes: 1929-1934, 1935-1939, and 1940-1946. This use was due to the decisions made by the authorities of the Colegio Secundario de Señoritas, which also implied different ways of understanding and teaching the subject. From a qualitative methodological strategy, we propose the interpretation of a case, approaching it from the tools coming from the critical perspective of gender and visual history. We use written and visual sources, as well as semi-structured interviews with former students. We consider that the obligatory nature of uniforms, in relation to the construction of femininities, involves moral, aesthetic, sexual, material, erotic, and kinetic dimensions. In this sense, we conclude that what happened with the teaching of Physical Education in the Colegio Secundario de Señoritas, in terms of the transmission of femininities, accounts for a permanent tension in society between equality and inequality between women and men, without not be a linear path at all from inequality to equality or less inequality.
DOI: 10.6084/m9.figshare.22982140.v1
title: PHYSICAL EDUCATION, FEMNITIES AND UNIFORMS. THE CASE OF THE DEPARTAMENTO DE CULTURA FÍSICA (1929-1946) OF THE UNIVERSIDAD NACIONAL DE LA PLATA (ARGENTINE)

description: ABSTRACT: We investigate the construction of femininities from the use of uniforms for Physical Education classes. For this, we base ourselves on the case of the Department of Physical Culture, an institution that existed between 1929 and 1946, of the National University of La Plata (Buenos Aires, Argentina). We wonder about how and why the Physical Education uniforms contributed to gendering and sexualizing the bodies of female students. We build three periods from the mandatory establishment of female uniforms for Gymnastics classes: 1929-1934, 1935-1939, and 1940-1946. This use was due to the decisions made by the authorities of the Colegio Secundario de Señoritas, which also implied different ways of understanding and teaching the subject. From a qualitative methodological strategy, we propose the interpretation of a case, approaching it from the tools coming from the critical perspective of gender and visual history. We use written and visual sources, as well as semi-structured interviews with former students. We consider that the obligatory nature of uniforms, in relation to the construction of femininities, involves moral, aesthetic, sexual, material, erotic, and kinetic dimensions. In this sense, we conclude that what happened with the teaching of Physical Education in the Colegio Secundario de Señoritas, in terms of the transmission of femininities, accounts for a permanent tension in society between equality and inequality between women and men, without not be a linear path at all from inequality to equality or less inequality.
DOI: 10.6084/m9.figshare.22982155
title: Elderly people with human T-cell leukemia virus type 1-associated myelopathy present an early impairment in cognitive skills

description: Abstract Background Cerebral changes occur in individuals with human T-cell leukemia virus type 1 (HTLV-1 )-associated myelopathy (HAM) and seem to predominate in subcortical areas. Little is known about the cognitive decline in the elderly living with HTLV-1. Objective To evaluate the cognitive aging of individuals infected with HTLV-1 aged ≥ 50 years. Methods This is a cross-sectional study of former blood donors infected with HTLV-1 who have been followed in the cohort of the Interdisciplinary Research Group on HTLV-1 since 1997. The groups of study consisted of 79 HTLV-1 infected individuals aged ≥ 50 years, with 41 of them presenting symptomatic HAM and 38 being asymptomatic carriers, and 59 seronegative individuals (controls) aged ≥ 60 years. All were submitted to the P300 electrophysiological test and neuropsychological tests. Results Individuals with HAM presented delayed P300 latency in relation to the other groups, and this latency delay increased progressively with aging. The performance of this group in the neuropsychological tests was also the worst. The HTLV-1- asymptomatic group performance was similar to that of the control group. Conclusions Individuals with HAM presented cognitive decline that progressed with aging and, although HTLV-1-asymptomatic carriers appear to present cognitive aging similar to that of healthy elderly people, concern about a subclinical cognitive impairment is warranted in this population.
DOI: 10.6084/m9.figshare.22982155.v1
title: Elderly people with human T-cell leukemia virus type 1-associated myelopathy present an early impairment in cognitive skills

description: Abstract Background Cerebral changes occur in individuals with human T-cell leukemia virus type 1 (HTLV-1 )-associated myelopathy (HAM) and seem to predominate in subcortical areas. Little is known about the cognitive decline in the elderly living with HTLV-1. Objective To evaluate the cognitive aging of individuals infected with HTLV-1 aged ≥ 50 years. Methods This is a cross-sectional study of former blood donors infected with HTLV-1 who have been followed in the cohort of the Interdisciplinary Research Group on HTLV-1 since 1997. The groups of study consisted of 79 HTLV-1 infected individuals aged ≥ 50 years, with 41 of them presenting symptomatic HAM and 38 being asymptomatic carriers, and 59 seronegative individuals (controls) aged ≥ 60 years. All were submitted to the P300 electrophysiological test and neuropsychological tests. Results Individuals with HAM presented delayed P300 latency in relation to the other groups, and this latency delay increased progressively with aging. The performance of this group in the neuropsychological tests was also the worst. The HTLV-1- asymptomatic group performance was similar to that of the control group. Conclusions Individuals with HAM presented cognitive decline that progressed with aging and, although HTLV-1-asymptomatic carriers appear to present cognitive aging similar to that of healthy elderly people, concern about a subclinical cognitive impairment is warranted in this population.
DOI: 10.6084/m9.figshare.22815594
title: Genetic connectivity in the spotted rose snapper Lutjanus guttatus (Lutjaniformes: Lutjanidae) between Mexico and Panama throughout the Tropical Eastern Pacific

description: Abstract The spotted rose snapper, Lutjanus guttatus, is an important fishery species with high potential for aquaculture. Genetic characterization of its natural populations is necessary to avoid stock collapse and loss of genetic diversity. Previous studies carried out in the Tropical Eastern Pacific (TEP), however, have shown contrasting results in the genetic structure of fish populations, particularly in species of Lutjanidae. Therefore, to understand the genetic structure of spotted rose snapper in the TEP, twelve microsatellite loci were used to assess the genetic diversity and explore the hypothesis of population genetic structure in samples of the species collected throughout the TEP. Fin clips from 186 sampled individuals (27 to 49 per site) were analyzed from five sites in the three regional biogeographic provinces, delimited by shoreline reef habitat breaks: La Paz (Cortez province), Colima and Oaxaca (Mexican province), Chiriqui and Port of Panama (Panamic province). Results of global Analysis of Molecular Variance (AMOVA), population pairwise FST, hierarchical AMOVA, and a discriminant analysis of principal components (DAPC) reflected a panmictic population involving the entire set of sampled sites. The role of larval dispersal, post-recruitment migration, and marine current dynamics as drivers of genetic connectivity in this species is discussed.
DOI: 10.6084/m9.figshare.22815594.v1
title: Genetic connectivity in the spotted rose snapper Lutjanus guttatus (Lutjaniformes: Lutjanidae) between Mexico and Panama throughout the Tropical Eastern Pacific

description: Abstract The spotted rose snapper, Lutjanus guttatus, is an important fishery species with high potential for aquaculture. Genetic characterization of its natural populations is necessary to avoid stock collapse and loss of genetic diversity. Previous studies carried out in the Tropical Eastern Pacific (TEP), however, have shown contrasting results in the genetic structure of fish populations, particularly in species of Lutjanidae. Therefore, to understand the genetic structure of spotted rose snapper in the TEP, twelve microsatellite loci were used to assess the genetic diversity and explore the hypothesis of population genetic structure in samples of the species collected throughout the TEP. Fin clips from 186 sampled individuals (27 to 49 per site) were analyzed from five sites in the three regional biogeographic provinces, delimited by shoreline reef habitat breaks: La Paz (Cortez province), Colima and Oaxaca (Mexican province), Chiriqui and Port of Panama (Panamic province). Results of global Analysis of Molecular Variance (AMOVA), population pairwise FST, hierarchical AMOVA, and a discriminant analysis of principal components (DAPC) reflected a panmictic population involving the entire set of sampled sites. The role of larval dispersal, post-recruitment migration, and marine current dynamics as drivers of genetic connectivity in this species is discussed.
DOI: 10.6084/m9.figshare.22982162
title: Fecal microbiota transplantation and its repercussions in patients with melanoma refractory to anti-PD-1 therapy: scope review

description: ABSTRACT Introduction: despite being extremely effective in some cases, up to 70% of patients with melanoma do not respond to anti-PD-1/PD-L1 (primary resistance) and many of the responders eventually progress (secondary resistance). Extensive efforts are being made to overcome this resistance through new strategies, especially aimed at modulating the intestinal microbiota. Objective: to assess whether fecal microbiota transplantation (FMT), associated with immunotherapy, is beneficial in the clinical course of patients with refractory melanoma. Methods: this is a scope review, based on studies collected on the MEDLINE, ScienceDirect, The Cochrane Library, Embase and BMJ Journals; using the terms: “Antibodies, Monoclonal”; “Drug Resistance, Neoplasm”; “Fecal Microbiota Transplantation”; “Host Microbial Interactions”; “Immunotherapy”; “Melanoma”; and “Microbiota”. Clinical trials, in English, with relevant data on the subject and fully available were included. A cut-off period was not determined, due to the limited amount of evidence on the topic. Results: crossing the descriptors allowed the identification of 342 publications and, after applying the eligibility criteria, allowed the selection of 4 studies. From the analyses, it was observed that a considerable part of those studied overcame resistance to immune checkpoint inhibitors after FMT, with better response to treatment, less tumor growth and increased beneficial immune response. Conclusion: it is noted that FMT favors the response of melanoma to immunotherapy, translated into significant clinical benefit. However, further studies are necessary for the complete elucidation of the bacteria and the mechanisms involved, as well as for the translation of new evidence to oncological care practice.
DOI: 10.6084/m9.figshare.22982162.v1
title: Fecal microbiota transplantation and its repercussions in patients with melanoma refractory to anti-PD-1 therapy: scope review

description: ABSTRACT Introduction: despite being extremely effective in some cases, up to 70% of patients with melanoma do not respond to anti-PD-1/PD-L1 (primary resistance) and many of the responders eventually progress (secondary resistance). Extensive efforts are being made to overcome this resistance through new strategies, especially aimed at modulating the intestinal microbiota. Objective: to assess whether fecal microbiota transplantation (FMT), associated with immunotherapy, is beneficial in the clinical course of patients with refractory melanoma. Methods: this is a scope review, based on studies collected on the MEDLINE, ScienceDirect, The Cochrane Library, Embase and BMJ Journals; using the terms: “Antibodies, Monoclonal”; “Drug Resistance, Neoplasm”; “Fecal Microbiota Transplantation”; “Host Microbial Interactions”; “Immunotherapy”; “Melanoma”; and “Microbiota”. Clinical trials, in English, with relevant data on the subject and fully available were included. A cut-off period was not determined, due to the limited amount of evidence on the topic. Results: crossing the descriptors allowed the identification of 342 publications and, after applying the eligibility criteria, allowed the selection of 4 studies. From the analyses, it was observed that a considerable part of those studied overcame resistance to immune checkpoint inhibitors after FMT, with better response to treatment, less tumor growth and increased beneficial immune response. Conclusion: it is noted that FMT favors the response of melanoma to immunotherapy, translated into significant clinical benefit. However, further studies are necessary for the complete elucidation of the bacteria and the mechanisms involved, as well as for the translation of new evidence to oncological care practice.