cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3886/e119981v1
title: The Impact of Renewable Energy Investment on Economic Growth

description: The study aimed to define and assess the impact of renewable energy on economic growth. It used panel data for 18 countries during the period 2008-2015. The FMOLS econometric technicality was used to estimate the relevant relations between the independent variables, namely; renewable energy, capital, labor and trade openness and the dependent variable, real GDP per capita. The study found that renewable energy affects economic growth positively, however, the elasticity was highly inelastic. Also, the study found positive and significant relationships between economic growth and the other three independent variables with inelastic elasticities.<br><br>The study concluded that countries should be encouraged to invest in renewable energy and gradually decrease their dependence on conventional energy. Also, it highly recommended to remove all obstacles facing the development of renewable energy.
DOI: 10.6084/m9.figshare.25003481.v1
title: Therapeutic effect of <i>Morus alba</i> leaf extract and chlorogenic acid on inhibiting the progression of kidney disease

description: It is well-established that <i>Morus alba</i> and its derivatives have been clinically proven to have antioxidant and anti-inflammatory properties. Although several studies have mentioned the beneficial effect of <i>Morus alba</i> on kidney disorders, the role of <i>Morus alba</i> in CKD still needs to be explored. Thus, this study investigated the effect of <i>Morus alba</i> and chlorogenic acid treatment on renal fibrosis in mice induced with unilateral urethral obstruction (UUO). Twenty-five Balb/c mice were randomly divided into five groups: the sham-operated group, the UUO untreated group, and the UUO treated with enalapril (ENA), <i>Morus alba</i> leaves extract (MLE) and chlorogenic acid (CGA) groups. Urine, blood, and organ samples were collected to evaluate urinalysis, haematology, biochemistry, and histopathology. The result indicated that the UUO group had significantly higher levels of creatinine (<i>p</i> &lt; 0.001) and urea (<i>p</i> &lt; 0.05), as well as hydronephrosis and urine crystal sedimentation (<i>p</i> &lt; 0.05). In comparison to the UUO group, the MLE and CGA groups displayed improved urine profiles, ameliorated anaemia (<i>p</i> &lt; 0.05), and urine crystals (<i>p</i> &lt; 0.05). The administration of CGA also significantly reduced serum creatinine (<i>p</i> &lt; 0.05) and protein-creatinine ratio (UPCr) levels. In addition, MLE and CGA could prevent hydronephrosis and delay renal damage, particularly in the dilation of Bowman’s space, tubular injury, loss of tubular epithelium, and cellular inflammation. In conclusion, <i>Morus alba</i> and CGA had a therapeutic effect in minimising the progression of renal damage. As a result, it can be promoted as a complementary renoprotective product based on natural products, as it has a potentially similar effect to enalapril. <i>Morus alba</i> is a plant that originated in China and has spread worldwide. This plant has been used in many civilisations for animal feed, culinary uses, and even traditional medicine. Indeed, several studies have shown that the leaves of Morus alba contain various phytochemicals that may positively affect health. Morus alba leaves contain a variety of phytochemicals, including phenolic acids, sterols, coumarins, anthocyanins, flavonoids, and flavonols. Several scientific studies have found that certain phytochemicals, particularly chlorogenic acid, have a beneficial effect on renal disease. In fact, Morus alba contains diuretic and free radical scavenging properties that may help prevent kidney damage. Thus, using the mice animal model, this study aimed to provide evidence of the effects of Morus alba leaf extract and chlorogenic acid on CKD symptoms.
DOI: 10.6084/m9.figshare.25003484
title: Supplementary Material for: SGLT2 inhibitors decrease overhydration and proteasuria in patients with chronic kidney disease: a longitudinal observational study

description: Introduction: SGLT2 inhibitors are used to reduce the risk of progression of chronic kidney disease (CKD). In patients with type 2 diabetes, they have been found to reduce extracellular volume. Given the high prevalence of extracellular volume expansion and overhydration in CKD, we investigated whether SGLT2 inhibitors might correct these disturbances in CKD patients.
Methods: CKD patients who started treatment with an SGLT2 inhibitor were investigated in this prospective observational study for 6 months. Body composition and fluid status were measured by bioimpedance spectroscopy. In addition, spot urine samples were analyzed for albuminuria, glucosuria and urinary aprotinin-sensitive serine protease activity.
Results: 42 patients (29 % with diabetic/hypertensive CKD, 31 % with IgA nephropathy; 88 % dapagliflozin 10 mg, 10 % dapagliflozin 5 mg, 2 % empagliflozin 20 mg; median eGFR 46 mL/min/1.73m² and albuminuria 1911 mg/g creatinine) participated in the study. Median glucosuria increased to 14 (10-19) g/g creatinine. At baseline, patients displayed overhydration (OH) with + 0.4 (-0.2 – 2.2) L/1.73m² which decreased by 0.5 (0.1 – 1.2) L/1.73m² after 6 months. Decrease of OH correlated with higher OH at BL, decrease of albuminuria, glucosuria and urinary aprotinin-sensitive protease activity. Adipose tissue mass was not significantly reduced after 6 months.
Conclusion: SGLT2 inhibitors reduce overhydration in patients with CKD, which is pronounced in the presence of high albuminuria, glucosuria and urinary aprotinin-sensitive protease activity.
DOI: 10.6084/m9.figshare.25003484.v1
title: Supplementary Material for: SGLT2 inhibitors decrease overhydration and proteasuria in patients with chronic kidney disease: a longitudinal observational study

description: Introduction: SGLT2 inhibitors are used to reduce the risk of progression of chronic kidney disease (CKD). In patients with type 2 diabetes, they have been found to reduce extracellular volume. Given the high prevalence of extracellular volume expansion and overhydration in CKD, we investigated whether SGLT2 inhibitors might correct these disturbances in CKD patients.
Methods: CKD patients who started treatment with an SGLT2 inhibitor were investigated in this prospective observational study for 6 months. Body composition and fluid status were measured by bioimpedance spectroscopy. In addition, spot urine samples were analyzed for albuminuria, glucosuria and urinary aprotinin-sensitive serine protease activity.
Results: 42 patients (29 % with diabetic/hypertensive CKD, 31 % with IgA nephropathy; 88 % dapagliflozin 10 mg, 10 % dapagliflozin 5 mg, 2 % empagliflozin 20 mg; median eGFR 46 mL/min/1.73m² and albuminuria 1911 mg/g creatinine) participated in the study. Median glucosuria increased to 14 (10-19) g/g creatinine. At baseline, patients displayed overhydration (OH) with + 0.4 (-0.2 – 2.2) L/1.73m² which decreased by 0.5 (0.1 – 1.2) L/1.73m² after 6 months. Decrease of OH correlated with higher OH at BL, decrease of albuminuria, glucosuria and urinary aprotinin-sensitive protease activity. Adipose tissue mass was not significantly reduced after 6 months.
Conclusion: SGLT2 inhibitors reduce overhydration in patients with CKD, which is pronounced in the presence of high albuminuria, glucosuria and urinary aprotinin-sensitive protease activity.
DOI: 10.18112/openneuro.ds004906.v2.1.1
title: rf_shimming_spinalcord
DOI: 10.18167/dvn1/hg0dny
title: Données techniques et socio-économiques des producteurs maraîchers dans 4 villes Ivoiriennes, 2023

description: Des informations sur les systèmes de production maraîchère dans les quatre zones d’intervention du projet MARIGO. Données techniques et socio-économiques (y compris des éléments de profil de risque) visant à comprendre les motivations des producteurs pour l'adoption de certains pratiques agricoles.
DOI: 10.6084/m9.figshare.24884580.v1
title: Supplementary Material for: Analysis of Immune-Related Adverse Events of Atezolizumab and Bevacizumab in Patients with Hepatocellular Carcinoma: A Multicenter Cohort Study

description: Background: Despite the emergence of atezolizumab and bevacizumab (A+B) as standard first-line systemic therapy for unresectable hepatocellular carcinoma (HCC), a comprehensive understanding of the clinical significance of immune-related adverse events (irAEs) remains limited. We aimed to assess the impact of irAEs on patients with HCC undergoing A+B treatment.
Methods: This multicentre retrospective study included consecutive patients with HCC who were treated with the A+B regimen from September 2020 to December 2022. Patients were categorised into three groups based on the severity of irAEs, ranging from those without any experience of irAEs to those with severe irAEs, classified as grade 3 or higher.
Results: This study included 150 patients with HCC, with a mean age of 63.3 years. Among them, 93.3% of patients were classified as Barcelona Clinic Liver Cancer stage C, 52.0% had portal vein tumour thrombosis (PVTT), and 60.7% extrahepatic spread. Patients were classified as follows: Group 1 (n = 84) had no irAEs, Group 2 (n = 37) had mild irAEs (grade 1–2), and Group 3 (n = 29) had severe irAEs (grade ≥ 3). The median overall survival (OS), progression-free survival (PFS), and time-to-treatment discontinuation (TTD) were 13.6, 5.7, and 3.6 months, respectively. Group 2 demonstrated significantly superior OS compared to Group 1 (9.5 months) and Group 3 (5.6 months), with a median OS of 23.0 months (p &lt; 0.001). Furthermore, Group 2 demonstrated significantly better outcomes in terms of PFS and TTD compared to both Group 1 and Group 3 (p &lt; 0.001 for both). Multivariate analysis identified mild irAEs (hazard ratio [HR], 0.353; p = 0.010), ALBI grade 1 (HR, 0.389; p = 0.006), Child-Pugh class A (HR, 0.338; p = 0.002), and the absence of PVTT (HR, 0.556; p = 0.043) as independent predictors of better OS.
Conclusions: Our study highlights the significant impact of irAE severity on the outcomes of patients with HCC receiving A+B. Notably, the occurrence of mild irAEs was independently associated with favourable survival, suggesting their potential role as surrogate indicators of HCC prognosis.
DOI: 10.5281/zenodo.10518321
title: Data Analysis files for "Emergent Macroscopic Bistability Induced by a Single Superconducting Qubit"

description: Data analysis files for the manuscript "Emergent Macroscopic Bistability Induced by a Single Superconducting Qubit".

This contains the raw data and the data analysis files for generating the figures in the manuscript.



 Figure1 file - The raw data of cavity transmission spectra for 6 different kappas are there. They are fitted with input-output theory in the python file.

 Figure2 file - The raw data at 8 MHz kappa are included. all hte figures in figure 2 are generated in the python file

 Figure3 file - The raw data of PBB single shot measurements at all kappas are included. The detailed analysis and the Figure3 generated for the paper are all in the python analysis file. Also, thefiles containing the time-evolution of the intensity from Master Equation solution are included.

Figure4 file - The raw data at 2.6 MHz for different drive detunings and the corresponding analyses are included. And the python file includes the analysis of the experimental data as well as approximate neoclassical equations solutions for 2-level and 3-level transmons are included.
DOI: 10.6084/m9.figshare.25003559
title: Ice flow dynamics of the northwestern Laurentide Ice Sheet during the last deglaciation

description: Supplementary materials
DOI: 10.6084/m9.figshare.25003559.v1
title: Ice flow dynamics of the northwestern Laurentide Ice Sheet during the last deglaciation

description: Supplementary materials
DOI: 10.6084/m9.figshare.23987903
title: A review on biological occurrence, bioaccumulation, transmission and metabolism of chlorinated paraffins

description: Chlorinated paraffins (CPs) are widely used persistent organic pollutants (POPs). Based on the carbon chain length, CPs can be classified as short-chain (C<sub>10-13</sub>) CPs (SCCPs), medium-chain (C<sub>14-17</sub>) CPs (MCCPs), and long-chain (<i>C</i><sub>≥18</sub>) CPs (LCCPs). Since SCCPs have been listed as POPs of particular concern by the Stockholm Convention, the production of MCCPs and LCCPs is increased sharply. Therefore, the number of studies focusing on MCCPs and LCCPs has increased recently. Herein, we comprehensively reviewed recent studies on the biological occurrence, bioaccumulation, transmission, and transformation of CPs. CPs are pervasively distributed across biotas and exhibit diverse accumulation properties in different tissues. MCCPs and LCCPs are more abundant than SCCPs in some organisms. The absorption, translocation, and elimination behaviors of CPs directly influence their accumulation in organisms. The maternal transfer is an elimination pathway for CPs and could explain the discrepancy in CPs accumulation in opposite sexes of some organisms. With the establishment of novel screening methods, several transformation products of CPs have been identified in plants, microorganisms, and humans. By comparing the biotransformation pathways of CPs in different organisms, common and unique pathways have been identified in various species, although further studies on the transformation of CPs in humans and other animals are required. This review describes some noteworthy and prospective studies focused on the biological behavior of CPs. The review also derives novel conclusions based on recent studies in this field to provide a comprehensive understanding of the environmental fate of CPs.
DOI: 10.6084/m9.figshare.23987903.v1
title: A review on biological occurrence, bioaccumulation, transmission and metabolism of chlorinated paraffins

description: Chlorinated paraffins (CPs) are widely used persistent organic pollutants (POPs). Based on the carbon chain length, CPs can be classified as short-chain (C<sub>10-13</sub>) CPs (SCCPs), medium-chain (C<sub>14-17</sub>) CPs (MCCPs), and long-chain (<i>C</i><sub>≥18</sub>) CPs (LCCPs). Since SCCPs have been listed as POPs of particular concern by the Stockholm Convention, the production of MCCPs and LCCPs is increased sharply. Therefore, the number of studies focusing on MCCPs and LCCPs has increased recently. Herein, we comprehensively reviewed recent studies on the biological occurrence, bioaccumulation, transmission, and transformation of CPs. CPs are pervasively distributed across biotas and exhibit diverse accumulation properties in different tissues. MCCPs and LCCPs are more abundant than SCCPs in some organisms. The absorption, translocation, and elimination behaviors of CPs directly influence their accumulation in organisms. The maternal transfer is an elimination pathway for CPs and could explain the discrepancy in CPs accumulation in opposite sexes of some organisms. With the establishment of novel screening methods, several transformation products of CPs have been identified in plants, microorganisms, and humans. By comparing the biotransformation pathways of CPs in different organisms, common and unique pathways have been identified in various species, although further studies on the transformation of CPs in humans and other animals are required. This review describes some noteworthy and prospective studies focused on the biological behavior of CPs. The review also derives novel conclusions based on recent studies in this field to provide a comprehensive understanding of the environmental fate of CPs.
DOI: 10.6084/m9.figshare.15047403
title: Energy transfer from PSI-generated M1 subharmonic waves to high-frequency internal waves

description: This item includes the datasets utilized in the article for submission to Geophysical Research Letters
DOI: 10.6084/m9.figshare.15047403.v1
title: Energy transfer from PSI-generated M1 subharmonic waves to high-frequency internal waves

description: This item includes the datasets utilized in the article for submission to Geophysical Research Letters
DOI: 10.5281/zenodo.10518842
title: Bridging the gap: a new module for human water use in the Community Earth System Model version 2.2 (Data)

description: Data required to reproduce figures from the Taranu, I.S., Lawrence, D., Wada, Y., Tang, T., Kluzek, E., Rabin, S., Yao, Y., Hertog, S.J.D., Vanderkelen, I., Thiery, W., n.d. Bridging the gap: a new module for human water use in the Community Earth System Model version 2.2.
DOI: 10.5281/zenodo.10518843
title: Bridging the gap: a new module for human water use in the Community Earth System Model version 2.2 (Data)

description: Data required to reproduce figures from the Taranu, I.S., Lawrence, D., Wada, Y., Tang, T., Kluzek, E., Rabin, S., Yao, Y., Hertog, S.J.D., Vanderkelen, I., Thiery, W., n.d. Bridging the gap: a new module for human water use in the Community Earth System Model version 2.2.
DOI: 10.6084/m9.figshare.24935994
title: Supplementary Material for: GSK-3β as a potential coordinator of anabolic and catabolic pathways in hepatitis C virus insulin resistance

description: Introduction: Chronic HCV infection results in insulin resistance (IR) through interaction of pathways for glucose homeostasis, insulin signaling, and autophagy. Not known is how soon the pathways are activated, and how IR is related to the signals generated by catabolic and anabolic conditions occurring in infected cells. We have extended our studies to a cell culture system mimicking acute infection and to downstream pathways involving energy-sensor AMPK and nutrient-sensor mTOR that are active in catabolic and anabolic processes within the infected cells.
Methods: Huh7 liver cells were infected with HCV. We performed proteomics analysis of key proteins in infected cells by western blotting and IP experiments, with or without interferon-α exposure.
Results: We show that IRS-1 Ser312, Beclin-1, protein conjugate Atg12-Atg5 or GS Ser641 are upregulated early in infection by activating the same pathways utilized for persistent infection; Bcl-XL, an inhibitor of both autophagy and apoptosis, is present in a core-complex with IRS-1 Ser312 and Beclin-1 during progression of IR; AMPK level remains the same in infected cells where it is activated by phosphorylation at Thr172 concomitant with increased autophagy, a hallmark of catabolic conditions; an mTOR level that promotes anabolism is increased rather than decreased under an expanded autophagy; hypophosphorylation of translational repressor 4E-BP1 downstream of mTOR is suggestive of reduced protein synthesis; and β-catenin is upregulated but not phosphorylated suggesting indirectly our previous contention that its kinase, GSK-3β, is mostly in an inactive state. 
Discussion/Conclusion: We report that in the development of IR following chronic infection, anabolic and catabolic pathways are activated early, and the metabolic interaction occurs possibly in a core-complex with IRS-1 Ser312, Beclin-1 and autophagy inhibitor BcL-XL. Induction of autophagy is usually controlled by a two-edged mechanism acting in opposition under anabolic and catabolic conditions by AMPK/mTOR/4E-BP1 pathways with GSK-3β mediated feed-back loops. However, we observed that an up-regulation of mTOR along with an up-regulation of AMPK caused by HCV infection is a deviation from the normal scenario described above which might be of therapeutic interest.
DOI: 10.6084/m9.figshare.24935994.v1
title: Supplementary Material for: GSK-3β as a potential coordinator of anabolic and catabolic pathways in hepatitis C virus insulin resistance

description: Introduction: Chronic HCV infection results in insulin resistance (IR) through interaction of pathways for glucose homeostasis, insulin signaling, and autophagy. Not known is how soon the pathways are activated, and how IR is related to the signals generated by catabolic and anabolic conditions occurring in infected cells. We have extended our studies to a cell culture system mimicking acute infection and to downstream pathways involving energy-sensor AMPK and nutrient-sensor mTOR that are active in catabolic and anabolic processes within the infected cells.
Methods: Huh7 liver cells were infected with HCV. We performed proteomics analysis of key proteins in infected cells by western blotting and IP experiments, with or without interferon-α exposure.
Results: We show that IRS-1 Ser312, Beclin-1, protein conjugate Atg12-Atg5 or GS Ser641 are upregulated early in infection by activating the same pathways utilized for persistent infection; Bcl-XL, an inhibitor of both autophagy and apoptosis, is present in a core-complex with IRS-1 Ser312 and Beclin-1 during progression of IR; AMPK level remains the same in infected cells where it is activated by phosphorylation at Thr172 concomitant with increased autophagy, a hallmark of catabolic conditions; an mTOR level that promotes anabolism is increased rather than decreased under an expanded autophagy; hypophosphorylation of translational repressor 4E-BP1 downstream of mTOR is suggestive of reduced protein synthesis; and β-catenin is upregulated but not phosphorylated suggesting indirectly our previous contention that its kinase, GSK-3β, is mostly in an inactive state. 
Discussion/Conclusion: We report that in the development of IR following chronic infection, anabolic and catabolic pathways are activated early, and the metabolic interaction occurs possibly in a core-complex with IRS-1 Ser312, Beclin-1 and autophagy inhibitor BcL-XL. Induction of autophagy is usually controlled by a two-edged mechanism acting in opposition under anabolic and catabolic conditions by AMPK/mTOR/4E-BP1 pathways with GSK-3β mediated feed-back loops. However, we observed that an up-regulation of mTOR along with an up-regulation of AMPK caused by HCV infection is a deviation from the normal scenario described above which might be of therapeutic interest.
DOI: 10.6084/m9.figshare.25003610
title: Codes and data for Signal compression and its function in long-distance loud calls of the white-headed langur <i>(Trachypithecus leucocephalus)</i>

description: The project contain datd, analysisa and plot code about white-headed langur of lingustic law
DOI: 10.6084/m9.figshare.25003610.v2
title: Codes and data for Signal compression and its function in long-distance loud calls of the white-headed langur <i>(Trachypithecus leucocephalus)</i>

description: The project contain datd, analysisa and plot code about white-headed langur of lingustic law
DOI: 10.6084/m9.figshare.25003610.v1
title: Codes and data for Signal compression and its function in long-distance loud calls of the white-headed langur (Trachypithecus leucocephalus)

description: The project contain datd, analysisa and plot code about white-headed langur of lingustic law
DOI: 10.5281/zenodo.10519142
title: OME-Zarr scMultipleX Test dataset

description: Test dataset based on https://zenodo.org/records/10257149

 

Contains expected measurements for scMultipleX measurements in version 0.5.0, as well as additional empty labels.

 

Also includes a Fractal workflow to recreate this dataset
DOI: 10.5281/zenodo.10519143
title: OME-Zarr scMultipleX Test dataset

description: Test dataset based on https://zenodo.org/records/10257149

 

Contains expected measurements for scMultipleX measurements in version 0.5.0, as well as additional empty labels.

 

Also includes a Fractal workflow to recreate this dataset