cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9739613.v1
title: Brazilian multicenter study on pegvisomant treatment in acromegaly

description: ABSTRACT Objective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during treatment. Safety data were reviewed. Predictors of response were determined by comparing controlled versus uncontrolled patients. Results 109 patients [61 women; median age at diagnosis 34 years; 95.3% macroadenomas] from 10 Brazilian centers were studied. Previous treatment included surgery (89%), radiotherapy (34%), somatostatin receptor ligands (99%), and cabergoline (67%). Before PEGV, median levels of GH, IGF-I and IGF-I % of upper limit of normal were 4.3 µg/L, 613 ng/mL, and 209%, respectively. Pre-diabetes/diabetes was present in 48.6% and tumor remnant in 71% of patients. Initial dose was 10 mg/day in all except 4 cases, maximum dose was 30 mg/day, and median exposure time was 30.5 months. PEGV was used as monotherapy in 11% of cases. Normal IGF-I levels was obtained in 74.1% of patients. Glycemic control improved in 56.6% of patients with pre-diabetes/diabetes. Exposure time, pre-treatment GH and IGF-I levels were predictors of response. Tumor enlargement occurred in 6.5% and elevation of liver enzymes in 9.2%. PEGV was discontinued in 6 patients and 3 deaths unrelated to the drug were reported. Conclusions In a real-life scenario, PEGV is a highly effective and safe treatment for acromegaly patients not controlled with other therapies.
DOI: 10.6084/m9.figshare.6502784.v1
title: Heart Failure: Correlation between Anthropometric Parameters, Body Composition and Cell Integrity

description: Abstract Background: Knowledge about phase angle and its use as a prognostic determinant in patients with heart failure is still scarce. Objective: To evaluate the correlation between anthropometric indicators, cardiac function and cell integrity in patients with heart failure with reduced ejection fraction. Methods: This was a cross-sectional study that evaluated patients with heart failure with reduced ejection fraction by anthropometry and bioelectrical impedance analysis. Chi-square test and Student's t test were used to analyze differences, and Pearson's linear correlation was used to evaluate associations, using p &lt; 0.05 to indicate statistical significance. Results: We evaluated 41 subjects aged 30-74 years, of which 34 were men (82.9%). Mean phase angle was higher among women (7.1%), but significant differences between men and women were found only for body fat percentage. Phase angle correlated with body mass index (r = 0.44, p = 0.004) and there was a trend of correlation of the phase angle with waist-to-height ratio (r = 0.29, p = 0.06) and the left ventricular ejection fraction (r = 0.29, p = 0.07). Conclusions: Phase angle showed a good correlation with body mass index and showed a trend of correlation with the left ventricular ejection fraction, supporting the obesity paradox and the prognostic importance of this marker. Further studies on the applicability of the phase angle in the prognosis of these patients are still needed.
DOI: 10.6084/m9.figshare.7512263
title: Study of the microstructure and mechanical properties of beta tricalcium phosphate-based composites with alumina addition produced by powder metallurgy

description: Abstract The use of alumina as a reinforcement in metallic and ceramic matrix is well-known. The purpose of this study was to investigate the effect of alumina addition according to its amount on the microstructural and mechanical behavior of tricalcium phosphate ceramic (TCP), more specifically the β-TCP. Although β-TCP has excellent bioactive and biocompatible properties, it presents low fracture resistance and load bearing capacity, which limits its use in the monolithic form. The route used for the β-TCP/alumina composite production was powder metallurgy. The powders were milled in a high energy ball mill with the following parameters: 5, 10, 15 and 20 hours, mass/sphere relation of 1:20 and speed of 150 rpm. After the milling process, the powders of both compositions were uniaxially pressed and sintered. Two of the compositions were processed containing 90% and 50% of β-TCP, respectively. The results indicated that composition 1 with a smaller percentage of alumina in its microstructure presented 62.4 % smaller particle size after the high energy ball milling process, which provided higher densification after pressing and sintering. These results implied in increased mechanical resistance, with 4.6 GPa of elastic modulus and 140 MPa of compressive strength, against 3.6 GPa of elastic modulus and 117 MPa of compressive strength obtained in composition 2.
DOI: 10.6084/m9.figshare.7512263.v1
title: Study of the microstructure and mechanical properties of beta tricalcium phosphate-based composites with alumina addition produced by powder metallurgy

description: Abstract The use of alumina as a reinforcement in metallic and ceramic matrix is well-known. The purpose of this study was to investigate the effect of alumina addition according to its amount on the microstructural and mechanical behavior of tricalcium phosphate ceramic (TCP), more specifically the β-TCP. Although β-TCP has excellent bioactive and biocompatible properties, it presents low fracture resistance and load bearing capacity, which limits its use in the monolithic form. The route used for the β-TCP/alumina composite production was powder metallurgy. The powders were milled in a high energy ball mill with the following parameters: 5, 10, 15 and 20 hours, mass/sphere relation of 1:20 and speed of 150 rpm. After the milling process, the powders of both compositions were uniaxially pressed and sintered. Two of the compositions were processed containing 90% and 50% of β-TCP, respectively. The results indicated that composition 1 with a smaller percentage of alumina in its microstructure presented 62.4 % smaller particle size after the high energy ball milling process, which provided higher densification after pressing and sintering. These results implied in increased mechanical resistance, with 4.6 GPa of elastic modulus and 140 MPa of compressive strength, against 3.6 GPa of elastic modulus and 117 MPa of compressive strength obtained in composition 2.
DOI: 10.6084/m9.figshare.7512266
title: Hydrometallurgical extraction of Al and Si from kaolinitic clays

description: Abstract Herein is presented the results of a study on the hydrometallurgic extraction and recovery of aluminum and silicon by leaching of kaolinitic clays with HF. The studied extraction parameters were: temperature, reaction time, solid/liquid ratio, concentration, and precipitating agent mass. In the leaching process, mineral dissolutions near 100% were obtained when working at 348 K, solid/liquid ratio 2% w/v, HF 12% v/v, for 120 minutes. The HF leach liquor generated from the dissolution of kaolinitic clays contains H2SiF6and H3AlF6. Studies were conducted to recover the two valuable fluorides as K2SiF6and Na3AlF6by precipitation with alkaline salts from the leach liquor. Phases of precipitated fluorides were identified by XRD and surface morphology by SEM. The purity of the K2SiF6precipitate was 98.8%, whereas for Na3AlF6, it was 89.3%. Also, both synthesized solids are of high commercial value due to their industrial applications.
DOI: 10.6084/m9.figshare.7514714.v1
title: PLANTING TIMES AND SPACING OF CARROT CROPS IN THE SÃO FRANCISCO VALLEY, PERNAMBUCO STATE, BRAZIL

description: ABSTRACT Climate variations over the year and plant density tend to strongly affect the agronomic performance of carrot crops. Thus, the objective of this work was to evaluate the performance of the cultivar Brasilia in crops under mild (winter) and high (summer) temperatures. An experiment was conducted from May 2011 to February 2012, using a randomized block design and treatments arranged in split plot, with three replications. The plots consisted of planting seasons (winter and summer) and the subplots of plant spacing (4,6, 8 and 10 cm). The height of plants presented a linear decrease, from 53.4 to 51.0 cm, with an increase in spacing in summer planting, while in winter the greatest height (50.7 cm) was obtained with spacing of 8.0 cm between plants. The lowest commercial yields were found in summer crops and with the widest spacing between plants. The smallest spacing between plants (4 cm) had yields of 45.9 Mg ha-1 in summer and of 63.1 Mg ha-1 in winter crops. The winter planting had higher fresh root weight (89.9 g root-1) compared to the summer (81.4 g root-1), reaching higher weight with increasing plant spacing. Higher yields are achieved with plant spacing of 4 cm during winter. The carrot can be grown throughout the year in the Submiddle of the São Francisco Valley.
DOI: 10.6084/m9.figshare.9739613
title: Brazilian multicenter study on pegvisomant treatment in acromegaly

description: ABSTRACT Objective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during treatment. Safety data were reviewed. Predictors of response were determined by comparing controlled versus uncontrolled patients. Results 109 patients [61 women; median age at diagnosis 34 years; 95.3% macroadenomas] from 10 Brazilian centers were studied. Previous treatment included surgery (89%), radiotherapy (34%), somatostatin receptor ligands (99%), and cabergoline (67%). Before PEGV, median levels of GH, IGF-I and IGF-I % of upper limit of normal were 4.3 µg/L, 613 ng/mL, and 209%, respectively. Pre-diabetes/diabetes was present in 48.6% and tumor remnant in 71% of patients. Initial dose was 10 mg/day in all except 4 cases, maximum dose was 30 mg/day, and median exposure time was 30.5 months. PEGV was used as monotherapy in 11% of cases. Normal IGF-I levels was obtained in 74.1% of patients. Glycemic control improved in 56.6% of patients with pre-diabetes/diabetes. Exposure time, pre-treatment GH and IGF-I levels were predictors of response. Tumor enlargement occurred in 6.5% and elevation of liver enzymes in 9.2%. PEGV was discontinued in 6 patients and 3 deaths unrelated to the drug were reported. Conclusions In a real-life scenario, PEGV is a highly effective and safe treatment for acromegaly patients not controlled with other therapies.
DOI: 10.6084/m9.figshare.6125213
title: A Scene of Exception: neotechnological theater in Belo Horizonte (Brazil) and Buenos Aires (Argentina)

description: Abstract9: This paper examines theater shows Play Me by Rodrigo Campos, premiered in Belo Horizonte, and Distancia by Matías Umpierrez and Las Ideas by Federico León, premiered in Buenos Aires. In the three shows, elements of digital media are used to momentarily replace the physical presence of actors. The micro-poetics of these productions are exceptions in the theatrical scene of two cities known for a lively theater scene, in which the coexistence of spectators and performers in the same space is appreciated. As exceptions, however, they shed light on an idiosyncrasy of the theater present in the two cities in relation to the neotechnological scene: the appreciation of coexistence and co-presence despite the absence introduced by the use of novel technologies.
DOI: 10.6084/m9.figshare.7512266.v1
title: Hydrometallurgical extraction of Al and Si from kaolinitic clays

description: Abstract Herein is presented the results of a study on the hydrometallurgic extraction and recovery of aluminum and silicon by leaching of kaolinitic clays with HF. The studied extraction parameters were: temperature, reaction time, solid/liquid ratio, concentration, and precipitating agent mass. In the leaching process, mineral dissolutions near 100% were obtained when working at 348 K, solid/liquid ratio 2% w/v, HF 12% v/v, for 120 minutes. The HF leach liquor generated from the dissolution of kaolinitic clays contains H2SiF6and H3AlF6. Studies were conducted to recover the two valuable fluorides as K2SiF6and Na3AlF6by precipitation with alkaline salts from the leach liquor. Phases of precipitated fluorides were identified by XRD and surface morphology by SEM. The purity of the K2SiF6precipitate was 98.8%, whereas for Na3AlF6, it was 89.3%. Also, both synthesized solids are of high commercial value due to their industrial applications.
DOI: 10.6084/m9.figshare.11350340
title: THE FOOD ACQUISITION PROGRAM AS AN INDUCER OF FOOD SOVEREIGNTY

description: Abstract The objective of this paper is to analyze the Simultaneous Donation Purchase modality of the Food Acquisition Program (PAA) in Mato Grosso state, emphasizing the diversified production, family consumption and promotion of food sovereignty among the peasants and those people served by the program. The four main methodological procedures used were: bibliographic and documentary research, data collection, the elaboration of cartographic representation, and the analysis of primary and secondary data. The primary data were collected from February to July 2016, through semi-structured interviews with peasant leaders who access or have accessed the PAA and the secondary data came from the National Supply Company (Conab). The findings were that the PAA impacts on social inclusion, strengthening peasant agriculture, which produces enough good quality food to meet the families’ dietary requirements and offers the possibility of selling any surplus. It is concluded that food sovereignty affirms the right of peasants and the people benefiting from the program to a culturally appropriate diet and the resources to produce food, thus reducing their dependence on capitalist markets.
DOI: 10.6084/m9.figshare.6125213.v1
title: A Scene of Exception: neotechnological theater in Belo Horizonte (Brazil) and Buenos Aires (Argentina)

description: Abstract9: This paper examines theater shows Play Me by Rodrigo Campos, premiered in Belo Horizonte, and Distancia by Matías Umpierrez and Las Ideas by Federico León, premiered in Buenos Aires. In the three shows, elements of digital media are used to momentarily replace the physical presence of actors. The micro-poetics of these productions are exceptions in the theatrical scene of two cities known for a lively theater scene, in which the coexistence of spectators and performers in the same space is appreciated. As exceptions, however, they shed light on an idiosyncrasy of the theater present in the two cities in relation to the neotechnological scene: the appreciation of coexistence and co-presence despite the absence introduced by the use of novel technologies.
DOI: 10.6084/m9.figshare.7510997.v1
title: Tectonic evolution of the Dom Feliciano Belt in Southern Brazil: Geological relationships and U-Pb geochronology

description: ABSTRACT: The Dom Feliciano Belt is an important Neoproterozoic to Cambrian orogenic complex, extending from eastern Uruguay to southern Brazil. It comprises a collage of oceanic domains and continental fragments developed between 900 and 540 Ma between the Rio de La Plata, Congo and Kalahari cratons. The integration of field and structural data with recent isotopic results has introduced new insights on the sources of the magmatism and sedimentary processes. This paper presents a review of the geochronological results combined with stratigraphic, structural and geochemical data. The evolution of the Dom Feliciano Belt involved three orogenic events known as the Passinho (0.89 - 0.86 Ga), São Gabriel (0.77 - 0.68 Ga) and Dom Feliciano (0.65 - 0.54 Ga). The first two events involved the closure of the Charrua Ocean generating an intra-oceanic arc (Passinho) and, subsequently, an active continental margin arc (São Gabriel). This ocean separated the continental areas represented by the Rio de la Plata Craton and the Nico Perez continental microplate. Closure of the Adamastor ocean resulted in an important collisional event between the Nico Perez Microplate/Rio de La Plata Craton and Kalahari and Congo cratons between 650 and 620 Ma, involving high T/intermediate P metamorphism. At this time of crustal thickening, the partition of the deformation controled the final evolution of the belt with important escape tectonics, responsible for nucleating crustal-scale transcurrent shear zones. These structures were deep and promoted the rise of mafic magmas, which, associated with high regional thermal gradient, lead to an important event of crustal reworking, responsible for the formation of the Pelotas Batholith. The orogenic collapse is represented by late magmatism of Pelotas Batholith and deposition of upper section of the Camaquã Basin.
DOI: 10.6084/m9.figshare.7513973
title: Students’ knowledge about patient image rights

description: Abstract The global diffusion of technologies, used by people today, including professionals and students in health institutions, makes it easy to capture and reproduce patient images, often without the prior obtaining of an informed consent. It was intended to obtain an expanded assessment of students’ knowledge about patient image rights. This was an observational study, with a quantitative approach performed with 263 students from dentistry and medical courses. Among the interviewees, 115 (43.7%) students reported having photographed or filmed a patient examination or medical record at some point and 192 (73%) participants reported that they did not know about any legislation regarding inappropriate use of images. It could be concluded that there is a gap in the training of these students in the use of patient images since the capture of images is present during the entire graduation course and, most of the time, the consent of the patient was obtained in an unusual way.
DOI: 10.6084/m9.figshare.7514714
title: PLANTING TIMES AND SPACING OF CARROT CROPS IN THE SÃO FRANCISCO VALLEY, PERNAMBUCO STATE, BRAZIL

description: ABSTRACT Climate variations over the year and plant density tend to strongly affect the agronomic performance of carrot crops. Thus, the objective of this work was to evaluate the performance of the cultivar Brasilia in crops under mild (winter) and high (summer) temperatures. An experiment was conducted from May 2011 to February 2012, using a randomized block design and treatments arranged in split plot, with three replications. The plots consisted of planting seasons (winter and summer) and the subplots of plant spacing (4,6, 8 and 10 cm). The height of plants presented a linear decrease, from 53.4 to 51.0 cm, with an increase in spacing in summer planting, while in winter the greatest height (50.7 cm) was obtained with spacing of 8.0 cm between plants. The lowest commercial yields were found in summer crops and with the widest spacing between plants. The smallest spacing between plants (4 cm) had yields of 45.9 Mg ha-1 in summer and of 63.1 Mg ha-1 in winter crops. The winter planting had higher fresh root weight (89.9 g root-1) compared to the summer (81.4 g root-1), reaching higher weight with increasing plant spacing. Higher yields are achieved with plant spacing of 4 cm during winter. The carrot can be grown throughout the year in the Submiddle of the São Francisco Valley.
DOI: 10.6084/m9.figshare.14272613
title: The relation between tourism and tecnology clusters and its impacts to the local development: a bibliometric study of scientific literature

description: ABSTRACT This paper intends to investigate the scientific literature on the relation between tourism and technology clusters (TourTech) in promoting local development on the databases Business Source Complete of the Online Research Databases (EBSCO) and Leisure Tourism Database (CABI) until the year 2014. With a mixed approach (qualitative and quantitative), the research is classified as descriptive and bibliographic. The strategy adopted for data collection used bibliometric criteria and the data analysis applied was content analysis. The results showed that there are some possible theoretical gaps to be developed: not only about the conection between tourism clusters and technology clusters for local development, but also the relation between tourism and technology clusters and their impact to promote innovation that can improve the local development and finally, how the investments to develop a cluster individually can impact on the development of the other.
DOI: 10.6084/m9.figshare.7510997
title: Tectonic evolution of the Dom Feliciano Belt in Southern Brazil: Geological relationships and U-Pb geochronology

description: ABSTRACT: The Dom Feliciano Belt is an important Neoproterozoic to Cambrian orogenic complex, extending from eastern Uruguay to southern Brazil. It comprises a collage of oceanic domains and continental fragments developed between 900 and 540 Ma between the Rio de La Plata, Congo and Kalahari cratons. The integration of field and structural data with recent isotopic results has introduced new insights on the sources of the magmatism and sedimentary processes. This paper presents a review of the geochronological results combined with stratigraphic, structural and geochemical data. The evolution of the Dom Feliciano Belt involved three orogenic events known as the Passinho (0.89 - 0.86 Ga), São Gabriel (0.77 - 0.68 Ga) and Dom Feliciano (0.65 - 0.54 Ga). The first two events involved the closure of the Charrua Ocean generating an intra-oceanic arc (Passinho) and, subsequently, an active continental margin arc (São Gabriel). This ocean separated the continental areas represented by the Rio de la Plata Craton and the Nico Perez continental microplate. Closure of the Adamastor ocean resulted in an important collisional event between the Nico Perez Microplate/Rio de La Plata Craton and Kalahari and Congo cratons between 650 and 620 Ma, involving high T/intermediate P metamorphism. At this time of crustal thickening, the partition of the deformation controled the final evolution of the belt with important escape tectonics, responsible for nucleating crustal-scale transcurrent shear zones. These structures were deep and promoted the rise of mafic magmas, which, associated with high regional thermal gradient, lead to an important event of crustal reworking, responsible for the formation of the Pelotas Batholith. The orogenic collapse is represented by late magmatism of Pelotas Batholith and deposition of upper section of the Camaquã Basin.
DOI: 10.6084/m9.figshare.7513973.v1
title: Students’ knowledge about patient image rights

description: Abstract The global diffusion of technologies, used by people today, including professionals and students in health institutions, makes it easy to capture and reproduce patient images, often without the prior obtaining of an informed consent. It was intended to obtain an expanded assessment of students’ knowledge about patient image rights. This was an observational study, with a quantitative approach performed with 263 students from dentistry and medical courses. Among the interviewees, 115 (43.7%) students reported having photographed or filmed a patient examination or medical record at some point and 192 (73%) participants reported that they did not know about any legislation regarding inappropriate use of images. It could be concluded that there is a gap in the training of these students in the use of patient images since the capture of images is present during the entire graduation course and, most of the time, the consent of the patient was obtained in an unusual way.