cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3213319.v1
title: Supplementary Material for: Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study

description: <br><strong><em>Background:</em></strong> In a prospective, single-center open study, we evaluated the very long-term effects of rituximab (RTX) administered to patients with severe mixed cryoglobulinemia (MC). <b><i>Methods:</i></b> RTX was administered to 31 patients with MC (type II in 29 cases and type III in 2) with diffuse membranoproliferative glomerulonephritis (16 cases), peripheral neuropathy (26) and large skin ulcers (7). All but 4 patients had serum anti-hepatitis C virus antibodies. RTX was administered at a dose of 375 mg/m<sup>2</sup>, according to a ‘4 + 2' protocol (days 1, 8, 15 and 22 plus 1 dose 1 and 2 months later). No other immunosuppressive drugs were added. Response was evaluated over a very long-term follow-up (mean 72.47 months, range 30-148). <b><i>Results:</i></b> Complete remission of pretreatment active manifestations was observed in all cases of purpuric lesions and non-healing vasculitic ulcers, and in 80% of the peripheral neuropathies. Cryoglobulinemic nephropathy significantly improved during follow-up, starting from the 2nd month after RTX (serum creatinine from 2.1 ± 1.7 to 1.5 ± 1.6 mg/dl, p ≤ 0.05; 24-hour proteinuria from 2.3 ± 2.1 to 0.9 ± 1.9 g/24 h, p ≤ 0.05). Improvement of cryoglobulinemic serological hallmarks, such as cryocrit and low complement C4, were observed. No clinically relevant side effects were recorded. Re-induction with RTX was carried out in 9 relapsed patients after a mean of 31.1 months (12-54), again with beneficial effects. The survival rate was 75% at 6 years and the probability of remaining symptom-free for 10 years without any therapy was of about 60% after a single ‘4 + 2' infusion cycle, while the probability of living symptom-free 5 years after relapsing was 80% if given the same treatment. <b><i>Conclusion:</i></b> In this open, prospective study, RTX appeared to be very effective and safe in the treatment of the most severe cases of MC.
DOI: 10.6084/m9.figshare.3208942.v1
title: Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein

description: <b>Context:</b> Baicalein is a major compound in extracts derived from <i>Scutellaria baicalensis</i> Georgi (Lamiaceae) which are used in the Traditional Chinese Medicine for the treatment of inflammatory and gastrointestinal diseases. This flavonoid is an activator of the Nrf2 signalling pathway but the molecular mechanism is not clearly established. <b>Objective:</b> We investigated the molecular mode of baicalein-mediated Nrf2-activation in Hct116 cells by the analysis of proteasomal activity, radical-scavenging activity and the comparison with baicalein derivatives. <b>Materials and methods:</b> The radical-scavenging activity (TEAC, DCF) up to 25 μM, cytotoxicity (MTT assay, 48 h) up to 100 μM, proteasomal activity and the Nrf2-activation (luciferase assay, ubiquitinylation, western blot, Ser40-phosphorylation; incubation for 1 or 4 h) by concentrations up to 40 or 50 μM of the compounds were analysed in Hct116 human colon carcinoma cells. <b>Results:</b> No change in the ubiquitinylation of Nrf2, proteasomal activity and transcription of the <i>NRF2</i> gene were detectable. Baicalein decreased the phosphorylation of Nrf2 (IC<sub>50-</sub>value approximately 20 μM) suggesting an inhibitory effect of the flavonoid on protein kinases. Since the activation of the Nrf2 pathway by baicalein might be also due to redox-activity of the compound, we investigated the effects of methylated baicalein derivatives oroxylin A, negeletein and baicaleintrimethylether. Oroxylin A and negletein showed a comparable redox-active potential, but only negletein (50 μM, 4 h) was able to activate Nrf2. <b>Conclusion:</b> This result confirms the hypothesis that baicalein, a component of extracts derived from <i>Baical Skullcap</i>, causes an activation of Nrf2 independent of a modulation of the cellular redox potential.
DOI: 10.6084/m9.figshare.3209908.v1
title: The dataset for study "Structural Alterations of Segmented Macular Inner Layers in Aquaporin4-Antibody-Positive Optic Neuritis Patients in a Chinese Population "

description: Data base suppoort results of the study "Structural Alterations of Segmented Macular Inner Layers in Aquaporin4-Antibody-Positive Optic Neuritis Patients in a Chinese Population ". It mainly includes perpapillary retinal nerve fiber layer thickness and inner macular segmented layers OCT measurements in AQP4-Ab negative and positive ON cohorts and healthy controls for 0-2 months, 2-4 months, 4-6 months and more than 6 months.
DOI: 10.6084/m9.figshare.3208549
title: Children with diabetes: Mothers’ quality of life

description: <b>Background</b>: Maternal functioning and well-being are important aspects of a family’s adaptation to chronic paediatric conditions. <b>Method</b>: This cross-sectional study investigated the difference between the perceived quality of life of mothers of children with diabetes (n = 63) and mothers of children without diabetes (n = 114). The study also examined the role of self-efficacy, relationship satisfaction, number of social support providers, and satisfaction with social support in predicting quality of life. <b>Results</b>: Mothers that had a child with diabetes had lower quality of life measured by general health, vitality, social functioning, role-emotional, and mental health than mothers that did not have a child with diabetes. Self-efficacy, relationship satisfaction, and social support were significant predictors of quality of life measured by mental health. <b>Conclusion</b>: Implications for research and potential interventions are discussed.
DOI: 10.6084/m9.figshare.3208498
title: Wikidata dump of 2016-01-04

description: This dataset is a dump of Wikidata in JSON format, produced in January 4, 2016 by the Wikimedia Foundation. Wikidata historical dumps are not preserved by the Wikimedia Foundation. Thus, this dump is distributed here in order to make our experiments repeatable along the time.<br>
DOI: 10.6084/m9.figshare.3208456
title: confusion matrices (3 groups, z-standardized data, 1000 measurement points)

description: R ObjectList of 3:List1: 1000 mean OOB errors of classificationList2: 1000 confusion matricesList3: 1000 mtry<br>
DOI: 10.6084/m9.figshare.3208345
title: OctylPyrimidopyrimidine

description: Chemdraw structure of dioctyl 2-oxopyrimido[4,5-<em>d</em>] pyrimidin-5(<em>6H</em>)-one and cyclic hexamer
DOI: 10.6084/m9.figshare.3208456.v1
title: confusion matrices (3 groups, z-standardized data, 1000 measurement points)

description: R ObjectList of 3:List1: 1000 mean OOB errors of classificationList2: 1000 confusion matricesList3: 1000 mtry<br>
DOI: 10.6084/m9.figshare.3208291
title: The Mouse Intestinal Bacterial Collection (miBC): Host-Specific Insight into Cultivable Diversity and Genomic Novelty of the Mouse Gut Microbiome

description: Cecal microbiota of mice (characterized with MiSeq Illumina) from different laboratories in Europe, USA and South America, and wild Mus musculus domesticus.
DOI: 10.6084/m9.figshare.3208291.v1
title: The Mouse Intestinal Bacterial Collection (miBC): Host-Specific Insight into Cultivable Diversity and Genomic Novelty of the Mouse Gut Microbiome

description: Cecal microbiota of mice (characterized with MiSeq Illumina) from different laboratories in Europe, USA and South America, and wild Mus musculus domesticus.
DOI: 10.6084/m9.figshare.3208189
title: Human T Study.xls

description: Dataset of human body temperature, male and female using Temporal Arterial Thermometry
DOI: 10.6084/m9.figshare.3208252
title: Data from: Spatial ecology of endophytes in Taiwan: combining traditional collection and next-generation sequence-based microbial survey techniques.

description: These are the original Illumina MiSeq and other datafiles associated with the paper: Spatial ecology in the Xylariaceae: combining traditional collection and next-generation sequence-based microbial survey techniques.
DOI: 10.6084/m9.figshare.3208189.v1
title: Human T Study.xls

description: Dataset of human body temperature, male and female using Temporal Arterial Thermometry
DOI: 10.6084/m9.figshare.3208102
title: Supplementary Material for: The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories

description: <b><i>Background/Aims:</i></b> Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are defined as neuroendocrine neoplasms (NENs) with a Ki-67 index &gt;20% according to the 2010 WHO classification. Some reports suggest that this category is heterogeneous. We retrospectively studied a series of 136 patients affected by grade 3 GEP-NECs with the aim to clarify the prognostic role of tumor morphological differentiation, proliferation, defect in mismatch repair proteins (MMRd), CD117 expression, and site of origin. The primary endpoint was the correlation between these parameters and the overall survival (OS). <b><i>Methods:</i></b> Univariate and multivariable Cox proportional hazards regression analyses were used to assess the prognostic significance of various clinical and histopathologic features. <b><i>Results:</i></b> With a median follow-up of 81 months, the median OS was 12.9 months. At multivariate analysis, morphological differentiation, Ki-67 index, MMRd, stage, and CD117 expression were independent prognostic markers in NECs. Three different prognostic categories of NECs were identified according to the degree of morphologic differentiation (well vs. poorly differentiated) and Ki-67 index (&lt;55% vs. ≥55%). On this basis, median OS was 43.6 months in well-differentiated neoplasms with a Ki-67 index 20-55% (named type A), 24.5 months in poorly differentiated neoplasms with a Ki-67 index 20-55% (type B), and 5.3 months (p &lt; 0.0001) in poorly differentiated neoplasms with a Ki-67 index ≥55% (type C). <b><i>Conclusions:</i></b> The present study suggests that GEP-NECs represent a heterogeneous group of neoplasms which can be better classified in different prognostic categories using both tumor morphology and Ki-67 index.
DOI: 10.6084/m9.figshare.3208087
title: Anexo Voz-Neuro

description: Usando fMRI, en este estudio se determina la efectividad de diversos elementos comunicativos en el ámbito de la publicidad medioambiental.<br>
DOI: 10.6084/m9.figshare.3208090
title: Force 2016 Pitch-It Innovation Challenge Voting Data

description: This is the voting data count for all projects involved in the Force 2016 Conference Pitch-It Innovation Challenge. The voting for the proposals was conducted by attendees at the conference on 04/19/2016 during the Pitch-It Innovation Challenge Panel at the Force 2016 Conference held in Portland, OR. There were two votes held to choose two winners of the challenge. The Force 2016 Pitch-It Innovation Challenge was sponsored by Jisc and conducted in their Jisc Elevator Service. The winners of the 2016 challenge were as follows: Round 1: Radian Data Education and Advocacy Portal and Round 2: Metric Toolkit.
DOI: 10.6084/m9.figshare.3208102.v1
title: Supplementary Material for: The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories

description: <b><i>Background/Aims:</i></b> Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are defined as neuroendocrine neoplasms (NENs) with a Ki-67 index &gt;20% according to the 2010 WHO classification. Some reports suggest that this category is heterogeneous. We retrospectively studied a series of 136 patients affected by grade 3 GEP-NECs with the aim to clarify the prognostic role of tumor morphological differentiation, proliferation, defect in mismatch repair proteins (MMRd), CD117 expression, and site of origin. The primary endpoint was the correlation between these parameters and the overall survival (OS). <b><i>Methods:</i></b> Univariate and multivariable Cox proportional hazards regression analyses were used to assess the prognostic significance of various clinical and histopathologic features. <b><i>Results:</i></b> With a median follow-up of 81 months, the median OS was 12.9 months. At multivariate analysis, morphological differentiation, Ki-67 index, MMRd, stage, and CD117 expression were independent prognostic markers in NECs. Three different prognostic categories of NECs were identified according to the degree of morphologic differentiation (well vs. poorly differentiated) and Ki-67 index (&lt;55% vs. ≥55%). On this basis, median OS was 43.6 months in well-differentiated neoplasms with a Ki-67 index 20-55% (named type A), 24.5 months in poorly differentiated neoplasms with a Ki-67 index 20-55% (type B), and 5.3 months (p &lt; 0.0001) in poorly differentiated neoplasms with a Ki-67 index ≥55% (type C). <b><i>Conclusions:</i></b> The present study suggests that GEP-NECs represent a heterogeneous group of neoplasms which can be better classified in different prognostic categories using both tumor morphology and Ki-67 index.
DOI: 10.6084/m9.figshare.3208060
title: Original

description: stuff
DOI: 10.6084/m9.figshare.3208060.v1
title: Original

description: stuff
DOI: 10.6084/m9.figshare.3208090.v1
title: Force 2016 Pitch-It Innovation Challenge Voting Data

description: This is the voting data count for all projects involved in the Force 2016 Conference Pitch-It Innovation Challenge. The voting for the proposals was conducted by attendees at the conference on 04/19/2016 during the Pitch-It Innovation Challenge Panel at the Force 2016 Conference held in Portland, OR. There were two votes held to choose two winners of the challenge. The Force 2016 Pitch-It Innovation Challenge was sponsored by Jisc and conducted in their Jisc Elevator Service. The winners of the 2016 challenge were as follows: Round 1: Radian Data Education and Advocacy Portal and Round 2: Metric Toolkit.
DOI: 10.6084/m9.figshare.3208087.v1
title: Anexo Voz-Neuro

description: Usando fMRI, en este estudio se determina la efectividad de diversos elementos comunicativos en el ámbito de la publicidad medioambiental.<br>
DOI: 10.6084/m9.figshare.3207991
title: LS-PASS_data.xlsx

description: <br>Interventional study on the safety and acceptability of the PrePex device in Lesotho
DOI: 10.6084/m9.figshare.3208006
title: Codebooks for LS-PASS data

description: Codebooks that explain the LS-PASS dataset
DOI: 10.6084/m9.figshare.3208006.v1
title: Codebooks for LS-PASS data

description: Codebooks that explain the LS-PASS dataset
DOI: 10.6084/m9.figshare.3207991.v1
title: LS-PASS_data.xlsx

description: <br>Interventional study on the safety and acceptability of the PrePex device in Lesotho
DOI: 10.6084/m9.figshare.3207859
title: The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets

description: Table S3: KS test including uncertainty in the age measurement
DOI: 10.6084/m9.figshare.3207856
title: The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets

description: Table S2: Chondrite values
DOI: 10.6084/m9.figshare.3207853
title: The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets

description: Table S1
DOI: 10.6084/m9.figshare.3207859.v1
title: The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets

description: Table S3: KS test including uncertainty in the age measurement
DOI: 10.6084/m9.figshare.3207856.v1
title: The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets

description: Table S2: Chondrite values
DOI: 10.6084/m9.figshare.3207832
title: DECS15 files

description: Files of the DECS15 v1 collection
DOI: 10.6084/m9.figshare.3207829
title: Prediction of a novel internal rearrangement of the insulin receptor

description: The insulin receptor (IR) plays critical roles in metabolism and growth, directed by the binding of insulin. Decades of research to understand the mechanism of insulin binding and activation of the IR have identified a region of the receptor, the <i>C</i>-terminal (CT) peptide, to be crucial for insulin binding. In particular, a truncated IR consisting of the first three domains fused to the CT peptide was found to bind insulin with nanomolar affinity, with undetectable binding in the absence of fused or soluble CT peptide. Problematically, all current crystal structures of the IR indicate the fusion point of the CT peptide to the three domains is located far from the position of the CT peptide as resolved in such structures. We have attempted to address this problem using molecular modelling and dynamics simulations. The results led to the identification of a potential inter-domain interaction between the L2 domain and the CT peptide that is not observed in any of the crystal structures of the IR. Investigations into this new interaction found a conformational change that could potentially be in response to insulin binding. Additionally, further simulation work with the new conformation demonstrated its compatibility with the position and orientation of insulin from the latest insulin-bound IR crystal structure.
DOI: 10.6084/m9.figshare.3207853.v1
title: The source of Dalradian detritus in the Buchan Block, NE Scotland: application of new tools to detrital datasets

description: Table S1
DOI: 10.6084/m9.figshare.3207808
title: First 2016 survey full bandwidth recordings and analysis of bats present

description: <br>Bayfordbury Survey<br>21 April 2016<br>20:00 - 21:45<br>Justin A T Halls<br>EM3+ 384ksps 16bit<br>Neumic at 5%51.776339, -0.0964033/3 cloud, temp (forecast) 10C-8CFirst Bayfordbury survey of the year.<br>Two static detectors - QMCI-S200 at 35kHz/x4<br>and Tascam DR05 with MEMS microphone. The first<br>located near the gate and the second near the big<br>tree by the small pond. GPS track indicates locations<br>and track walked goes from gate to each static location,<br>then back through the pinetum wood, before going past the Tascam<br>static recorder, across to the railway, down the railway path<br>then through the wood to the memorial, across the clearings and<br>back up the ride to the big tree to collect the Tascam<br>then down to the gate to collect the QMC and back to the<br>field centre.<br>Mainly Pips, one Barbie pass at 21:21, a few Natterers just<br>after leaving the wood, and some Daubs over the main lake at<br>the very end.<br>
DOI: 10.6084/m9.figshare.3207829.v2
title: Prediction of a novel internal rearrangement of the insulin receptor

description: The insulin receptor (IR) plays critical roles in metabolism and growth, directed by the binding of insulin. Decades of research to understand the mechanism of insulin binding and activation of the IR have identified a region of the receptor, the <i>C</i>-terminal (CT) peptide, to be crucial for insulin binding. In particular, a truncated IR consisting of the first three domains fused to the CT peptide was found to bind insulin with nanomolar affinity, with undetectable binding in the absence of fused or soluble CT peptide. Problematically, all current crystal structures of the IR indicate the fusion point of the CT peptide to the three domains is located far from the position of the CT peptide as resolved in such structures. We have attempted to address this problem using molecular modelling and dynamics simulations. The results led to the identification of a potential inter-domain interaction between the L2 domain and the CT peptide that is not observed in any of the crystal structures of the IR. Investigations into this new interaction found a conformational change that could potentially be in response to insulin binding. Additionally, further simulation work with the new conformation demonstrated its compatibility with the position and orientation of insulin from the latest insulin-bound IR crystal structure.
DOI: 10.5281/zenodo.3490434
title: Meaning maps and saliency models based on deep convolutional neural networks are insensitive to image meaning when predicting human fixations - data

description: Data from the paper:<em> Meaning maps and saliency models based on deep convolutional neural networks are insensitive to image meaning when predicting human fixations.</em> Preprint: https://www.biorxiv.org/content/10.1101/840256v1 Marek A. Pedziwiatr<br> marek.pedziwi@gmail.com<br> September 2020
DOI: 10.6084/m9.figshare.3207802
title: The source of SYBR Green master mix determines outcome of nucleic acid amplification reactions

description: Numerous real-time PCR devices and master mixes are available on the market. To perform reliable high-quality data, PCR master mix, and equipment need to be optimal. However, general lab optimized protocols are widely used for different gene targets and performed diversely between conditions. Our main objective was to test the robustness of different commercial SYBR green PCR mixes with respect to specificity and sensitivity of the PCR assay. This was tested across various PCR machines and amplification protocols for assessment of mRNA transcript levels, DNA copy numbers, and DNA genotypes.
DOI: 10.5281/zenodo.3490433
title: Meaning maps and saliency models based on deep convolutional neural networks are insensitive to image meaning when predicting human fixations - data

description: Data from the paper:<em> Meaning maps and saliency models based on deep convolutional neural networks are insensitive to image meaning when predicting human fixations.</em> Preprint: https://www.biorxiv.org/content/10.1101/840256v1 Marek A. Pedziwiatr<br> marek.pedziwi@gmail.com<br> September 2020
DOI: 10.6084/m9.figshare.3207832.v1
title: DECS15 files

description: Files of the DECS15 v1 collection
DOI: 10.6084/m9.figshare.3207832.v3
title: DECS15 files

description: Files of the DECS15 v1 collection
DOI: 10.6084/m9.figshare.3207808.v1
title: New draft item

description: <br>Bayfordbury Survey<br>21 April 2016<br>20:00 - 21:45<br>Justin A T Halls<br>EM3+ 384ksps 16bit<br>Neumic at 5%51.776339, -0.0964033/3 cloud, temp (forecast) 10C-8CFirst Bayfordbury survey of the year.<br>Two static detectors - QMCI-S200 at 35kHz/x4<br>and Tascam DR05 with MEMS microphone. The first<br>located near the gate and the second near the big<br>tree by the small pond. GPS track indicates locations<br>and track walked goes from gate to each static location,<br>then back through the pinetum wood, before going past the Tascam<br>static recorder, across to the railway, down the railway path<br>then through the wood to the memorial, across the clearings and<br>back up the ride to the big tree to collect the Tascam<br>then down to the gate to collect the QMC and back to the<br>field centre.<br>Mainly Pips, one Barbie pass at 21:21, a few Natterers just<br>after leaving the wood, and some Daubs over the main lake at<br>the very end.<br>
DOI: 10.6084/m9.figshare.3207832.v2
title: DECS15 files

description: Files of the DECS15 v1 collection
DOI: 10.6084/m9.figshare.3207802.v1
title: The source of SYBR Green master mix determines outcome of nucleic acid amplification reactions

description: Numerous real-time PCR devices and master mixes are available on the market. To perform reliable high-quality data, PCR master mix, and equipment need to be optimal. However, general lab optimized protocols are widely used for different gene targets and performed diversely between conditions. Our main objective was to test the robustness of different commercial SYBR green PCR mixes with respect to specificity and sensitivity of the PCR assay. This was tested across various PCR machines and amplification protocols for assessment of mRNA transcript levels, DNA copy numbers, and DNA genotypes.