DOI: 10.7270/q2wq061v
title: BindingDB Entry 50049182: Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.

description: Small molecule binding data for protein ALK tyrosine kinase receptor, Activin receptor type-1, Aurora kinase A, Aurora kinase B, Axin-1/Glycogen synthase kinase-3 beta, CAMK2A, CDK7/Cyclin H/MNAT1, CaM kinase I delta, CaM-kinase kinase beta, Casein kinase I isoform alpha, Cyclin-dependent kinase 2, Cyclin-dependent kinase 8, Cyclin-dependent kinase 9, Death-associated protein kinase 3, Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase, Dual specificity mitogen-activated protein kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase; MEK1/2, Dual specificity protein kinase CLK2, Dual specificity protein kinase TTK, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Epidermal growth factor receptor, Epithelial discoidin domain-containing receptor 1, Fibroblast growth factor receptor 1, Focal adhesion kinase 1, G protein-coupled receptor kinase 5, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Hepatocyte growth factor-like protein, High affinity nerve growth factor receptor, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Insulin receptor, Insulin-like growth factor I receptor, JNK2/JNK3, Leukocyte tyrosine kinase receptor, Macrophage colony-stimulating factor 1 receptor, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase kinase kinase 10, Mitogen-activated protein kinase kinase kinase kinase 4, Neurotrophic tyrosine kinase receptor, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Potassium voltage-gated channel subfamily H member 2, Protein kinase C iota type/zeta type, Protein kinase C theta type, Protein kinase C, PKC; classical/novel, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret , RAC-alpha serine/threonine-protein kinase AKT1, RAF serine/threonine protein kinase, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Ribosomal protein S6 kinase alpha-3, SRC, Serine/threonine-protein kinase 16, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase WEE1, Serine/threonine-protein kinase pim-2, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lck, Tyrosine-protein kinase SYK, Tyrosine-protein kinase receptor TYRO3, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), c-Jun N-terminal kinase, JNK, and cGMP-dependent protein kinase 1 beta, Uniprot L7RSL3, O00141, O14965, O43293, O60674, O75116, O75716, O94806, O95819, O96013, P00519, P00533, P04629, P06213, P06239, P06241, P07333, P07949, P08069, P08581, P09619, P11309, P11362, P12931, P15056, P16234, P17948, P24941, P26927, P29376, P30291, P31749, P33981, P34947, P35968, P36507, P43405, P45983, P45984, P46734, P48729, P49760, P49840, P49841, P50613, P50750, P51812, P51955, P52333, Q02750, Q02779, Q04759, Q04771, Q05397, Q05513, Q06187, Q06418, Q07912, Q08345, Q12809, Q12851, Q13464, Q13627, Q13976, Q14164, Q16288, Q16620, Q6FI23, Q8IU85, Q96GD4, Q96RR4, Q9UHD2, Q9UL54, Q9UM73, Q9UQM7, and Q9Y463