cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24329652
title: Publications on ultrasound-guided thermal ablation for thyroid nodules from 2000 to 2022: a bibliometric analysis

description: Thyroid nodules are increasingly treated with minimally invasive surgery. Thermal ablation could efficiently treat patients with benign thyroid nodules, recurrent thyroid cancer, and low-risk papillary thyroid carcinoma. This research aims to explore the research field of thermal ablation for thyroid nodules using bibliometric analysis. The web of science core collection (WoSCC) database was utilized from its inception to 1 October 2022, to collect research articles and reviews on ultrasound-guided thermal ablation for thyroid nodules. We applied the R package ‘bibliometrix’ to summarize the main findings, calculate the occurrences of the top keywords and visualize the international collaboration networks. The co-authorship and co-occurrence analyses were conducted with VOSviewer software. CiteSpace was used to identify the top references and keywords with the highest citation bursts. A total of 820 publications from 32 countries were retrieved. The annual number of related publications showed an increasing trend. China, Italy, and Korea were the most contributing countries. The University of Ulsan College of Medicine in Korea was the most productive institution, and Jung Hwan Baek published the maximum number of articles. The International Journal of Hyperthermia was the most productive journal. ‘Papillary thyroid micro-carcinoma (PTMC)’ and ‘association guideline’ were the most frequently used keywords in the field of thermal ablation for thyroid nodules, which indicated the potential hot research topics and frontiers in the future. This bibliometric study conducts a comprehensive analysis of publications on thermal ablation for thyroid nodules, which aids investigators in discovering potential research directions.
DOI: 10.6084/m9.figshare.24329652.v1
title: Publications on ultrasound-guided thermal ablation for thyroid nodules from 2000 to 2022: a bibliometric analysis

description: Thyroid nodules are increasingly treated with minimally invasive surgery. Thermal ablation could efficiently treat patients with benign thyroid nodules, recurrent thyroid cancer, and low-risk papillary thyroid carcinoma. This research aims to explore the research field of thermal ablation for thyroid nodules using bibliometric analysis. The web of science core collection (WoSCC) database was utilized from its inception to 1 October 2022, to collect research articles and reviews on ultrasound-guided thermal ablation for thyroid nodules. We applied the R package ‘bibliometrix’ to summarize the main findings, calculate the occurrences of the top keywords and visualize the international collaboration networks. The co-authorship and co-occurrence analyses were conducted with VOSviewer software. CiteSpace was used to identify the top references and keywords with the highest citation bursts. A total of 820 publications from 32 countries were retrieved. The annual number of related publications showed an increasing trend. China, Italy, and Korea were the most contributing countries. The University of Ulsan College of Medicine in Korea was the most productive institution, and Jung Hwan Baek published the maximum number of articles. The International Journal of Hyperthermia was the most productive journal. ‘Papillary thyroid micro-carcinoma (PTMC)’ and ‘association guideline’ were the most frequently used keywords in the field of thermal ablation for thyroid nodules, which indicated the potential hot research topics and frontiers in the future. This bibliometric study conducts a comprehensive analysis of publications on thermal ablation for thyroid nodules, which aids investigators in discovering potential research directions.
DOI: 10.6084/m9.figshare.23699809
title: Transvaginal ultrasound- and laparoscopy-guided percutaneous microwave ablation for adenomyosis has short- and long-term benefits: a single-center study

description: Transvaginal ultrasound- and laparoscopy-guided percutaneous microwave ablation (TLPMA) is a minimally invasive alternative technique with low risk, fast recovery and few side effects. We aimed to evaluate the safety and long-term efficacy of TLPMA for treating adenomyosis. We included 79 patients with symptomatic adenomyosis who underwent TLPMA and 44 patients with adenomyosis who received the levonorgestrel-releasing intrauterine system (LNG-IUS). We evaluated the role of laparoscopy in TLPMA as well as the short- and long-term effects of TLPMA. The mean age of the 79 patients who underwent TLPMA was 41.8 years. There was no difference in the mean age between the TLPMA and LNG-IUS groups. Laparoscopy could help to separate pelvic adhesions, provide a wide antenna path, and observe the uterine surface and bowel movement. No major complications were found in patients who underwent TLPMA. There was a significant post-treatment reduction in both the uterine and lesion volumes (<i>p</i> &lt; 0.001). After a median follow-up duration of 36 months (range: 1–60 months), the uterine and lesion volumes remained stable. Additionally, most patients remained without dysmenorrhea, which confirms the long-term efficacy of TLPMA. TLPMA is a feasible, minimally invasive technique for the treatment of adenomyosis, which significantly decreases the uterine and lesion volumes and has a good long-term effect.
DOI: 10.6084/m9.figshare.23699809.v1
title: Transvaginal ultrasound- and laparoscopy-guided percutaneous microwave ablation for adenomyosis has short- and long-term benefits: a single-center study

description: Transvaginal ultrasound- and laparoscopy-guided percutaneous microwave ablation (TLPMA) is a minimally invasive alternative technique with low risk, fast recovery and few side effects. We aimed to evaluate the safety and long-term efficacy of TLPMA for treating adenomyosis. We included 79 patients with symptomatic adenomyosis who underwent TLPMA and 44 patients with adenomyosis who received the levonorgestrel-releasing intrauterine system (LNG-IUS). We evaluated the role of laparoscopy in TLPMA as well as the short- and long-term effects of TLPMA. The mean age of the 79 patients who underwent TLPMA was 41.8 years. There was no difference in the mean age between the TLPMA and LNG-IUS groups. Laparoscopy could help to separate pelvic adhesions, provide a wide antenna path, and observe the uterine surface and bowel movement. No major complications were found in patients who underwent TLPMA. There was a significant post-treatment reduction in both the uterine and lesion volumes (<i>p</i> &lt; 0.001). After a median follow-up duration of 36 months (range: 1–60 months), the uterine and lesion volumes remained stable. Additionally, most patients remained without dysmenorrhea, which confirms the long-term efficacy of TLPMA. TLPMA is a feasible, minimally invasive technique for the treatment of adenomyosis, which significantly decreases the uterine and lesion volumes and has a good long-term effect.
DOI: 10.6084/m9.figshare.24438740
title: Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

description: This study aimed to assess the quality of the lucite cone applicator (LCA), the standard applicator for superficial hyperthermia at the Erasmus MC Cancer Institute, using the most recent quality assurance guidelines, thus verifying their feasibility. The assessment was conducted on each of the six LCAs available for clinical treatments. The temperature distribution was evaluated using an infrared camera across different layers of a fat-muscle mimicking phantom. The maximum temperature increase, thermal effective penetration depth (TEPD), and thermal effective field size (TEFS) were used as quality metrics. The experimental results were validated through comparison with simulated results, using a canonical phantom model and a realistic phantom model segmented from CT imaging. A maximum temperature increase above 6 °C at 2 cm depth in the fat-muscle phantom for all the experiments was found. A mean negative difference between simulated and experimental data was of 1.3 °C when using the canonical phantom model. This value decreased to a mean negative difference of 0.4 °C when using the realistic model. Simulated and measured TEPD showed good agreement for both <i>in silico</i> scenarios, while discrepancies were present for TEFS. The LCAs passed all QA guidelines requirements for superficial hyperthermia delivery when used singularly or in an array configuration. A further characterization of parameters such as antenna efficiency and heat transfer coefficients would be beneficial for translating experimental results to simulated values. Implementing the QA guidelines was time-consuming and demanding, requiring careful preparation and correct setup of antenna elements.
DOI: 10.6084/m9.figshare.24438740.v1
title: Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

description: This study aimed to assess the quality of the lucite cone applicator (LCA), the standard applicator for superficial hyperthermia at the Erasmus MC Cancer Institute, using the most recent quality assurance guidelines, thus verifying their feasibility. The assessment was conducted on each of the six LCAs available for clinical treatments. The temperature distribution was evaluated using an infrared camera across different layers of a fat-muscle mimicking phantom. The maximum temperature increase, thermal effective penetration depth (TEPD), and thermal effective field size (TEFS) were used as quality metrics. The experimental results were validated through comparison with simulated results, using a canonical phantom model and a realistic phantom model segmented from CT imaging. A maximum temperature increase above 6 °C at 2 cm depth in the fat-muscle phantom for all the experiments was found. A mean negative difference between simulated and experimental data was of 1.3 °C when using the canonical phantom model. This value decreased to a mean negative difference of 0.4 °C when using the realistic model. Simulated and measured TEPD showed good agreement for both <i>in silico</i> scenarios, while discrepancies were present for TEFS. The LCAs passed all QA guidelines requirements for superficial hyperthermia delivery when used singularly or in an array configuration. A further characterization of parameters such as antenna efficiency and heat transfer coefficients would be beneficial for translating experimental results to simulated values. Implementing the QA guidelines was time-consuming and demanding, requiring careful preparation and correct setup of antenna elements.
DOI: 10.5281/zenodo.8133800
title: Allāhābād इलाहाबाद الله آباد (Uttar Pradesh). Praśasti of Samudragupta, diplomatic edition.

description: Allāhābād इलाहाबाद الله آباد (Uttar Pradesh). Praśasti of Samudragupta, diplomatic edition.
DOI: 10.5281/zenodo.8133801
title: Allāhābād इलाहाबाद الله آباد (Uttar Pradesh). Praśasti of Samudragupta, diplomatic edition.

description: Allāhābād इलाहाबाद الله آباد (Uttar Pradesh). Praśasti of Samudragupta, diplomatic edition.
DOI: 10.5281/zenodo.10849168
title: Detection of allophane by Zhurong rover indicative of limited water-alteration at Utopia Planitia of Mars

description: Tianwen-1 mission is China’s first Martian exploration mission, and the Zhurong rover has successfully landed in southern Utopia Planitia. The MarSCoDe onboard the Zhurong rover can obtain mineralogical information on the Martian surface materials by using SWIR spectra. However, the exact types of hydrated phases are not clear in the existing literature. Thus we combined the SWIR spectra and laboratory database of binary mixtures to further constrain mineral types and their contents. Our results reveal that allophane may be the source of hydration features in the SWIR spectra of the Tianwen-1 landing site. This is of great significance to the geological interpretation and process of the landing site.
DOI: 10.5281/zenodo.10849169
title: Detection of allophane by Zhurong rover indicative of limited water-alteration at Utopia Planitia of Mars

description: Tianwen-1 mission is China’s first Martian exploration mission, and the Zhurong rover has successfully landed in southern Utopia Planitia. The MarSCoDe onboard the Zhurong rover can obtain mineralogical information on the Martian surface materials by using SWIR spectra. However, the exact types of hydrated phases are not clear in the existing literature. Thus we combined the SWIR spectra and laboratory database of binary mixtures to further constrain mineral types and their contents. Our results reveal that allophane may be the source of hydration features in the SWIR spectra of the Tianwen-1 landing site. This is of great significance to the geological interpretation and process of the landing site.
DOI: 10.6084/m9.figshare.17198567
title: Outdoor air pollution and the risk of asthma exacerbations in single lag0 and lag1 exposure patterns: a systematic review and meta-analysis

description: <b>Objective:</b> To synthesize evidence regarding the relationship between outdoor air pollution and risk of asthma exacerbations in single lag0 and lag1 exposure patterns. <b>Methods:</b> We performed a systematic literature search using PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials, China National Knowledge Internet, Chinese BioMedical, and Wanfang databases. Articles published until August 1, 2020 and the reference lists of the relevant articles were reviewed. Two authors independently evaluated the eligible articles and performed structured extraction of the relevant information. Pooled relative risks (RRs) and 95% confidence intervals (CIs) of lag0 and lag1 exposure patterns were estimated using random-effect models. <b>Results:</b> Eighty-four studies met the eligibility criteria and provided sufficient information for meta-analysis. Outdoor air pollutants were associated with increased risk of asthma exacerbations in both single lag0 and lag1 exposure patterns [lag0: RR (95% CI) (pollutants), 1.057(1.011, 1.103) (air quality index, AQI), 1.007 (1.005, 1.010) (particulate matter of diameter ≤ 2.5 μm, PM<sub>2.5</sub>), 1.009 (1.005, 1.012) (particulate matter of diameter, PM<sub>10</sub>), 1.010 (1.006, 1.014) (NO<sub>2</sub>), 1.030 (1.011, 1.048) (CO), 1.005 (1.002, 1.009) (O<sub>3</sub>); lag1:1.064(1.022, 1.106) (AQI), 1.005 (1.002, 1.008) (PM<sub>2.5</sub>), 1.007 (1.004, 1.011) (PM<sub>10</sub>), 1.008 (1.004, 1.012) (NO<sub>2</sub>), 1.025 (1.007, 1.042) (CO), 1.010 (1.006, 1.013) (O<sub>3</sub>)], except SO<sub>2</sub> [lag0: RR (95% CI), 1.004 (1.000, 1.007); lag1: RR (95% CI), 1.003 (0.999, 1.006)]. Subgroup analyses revealed stronger effects in children and asthma exacerbations associated with other events (including symptoms, lung function changes, and medication use). <b>Conclusion:</b> Outdoor air pollution increases the asthma exacerbation risk in single lag0 and lag1 exposure patterns. <b>Trial registration:</b> PROSPERO, CRD42020204097. https://www.crd.york.ac.uk/. Supplemental data for this article is available online at https://doi.org/10.1080/02770903.2021.2008429 .
DOI: 10.6084/m9.figshare.17198567.v2
title: Outdoor air pollution and the risk of asthma exacerbations in single lag0 and lag1 exposure patterns: a systematic review and meta-analysis

description: <b>Objective:</b> To synthesize evidence regarding the relationship between outdoor air pollution and risk of asthma exacerbations in single lag0 and lag1 exposure patterns. <b>Methods:</b> We performed a systematic literature search using PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials, China National Knowledge Internet, Chinese BioMedical, and Wanfang databases. Articles published until August 1, 2020 and the reference lists of the relevant articles were reviewed. Two authors independently evaluated the eligible articles and performed structured extraction of the relevant information. Pooled relative risks (RRs) and 95% confidence intervals (CIs) of lag0 and lag1 exposure patterns were estimated using random-effect models. <b>Results:</b> Eighty-four studies met the eligibility criteria and provided sufficient information for meta-analysis. Outdoor air pollutants were associated with increased risk of asthma exacerbations in both single lag0 and lag1 exposure patterns [lag0: RR (95% CI) (pollutants), 1.057(1.011, 1.103) (air quality index, AQI), 1.007 (1.005, 1.010) (particulate matter of diameter ≤ 2.5 μm, PM<sub>2.5</sub>), 1.009 (1.005, 1.012) (particulate matter of diameter, PM<sub>10</sub>), 1.010 (1.006, 1.014) (NO<sub>2</sub>), 1.030 (1.011, 1.048) (CO), 1.005 (1.002, 1.009) (O<sub>3</sub>); lag1:1.064(1.022, 1.106) (AQI), 1.005 (1.002, 1.008) (PM<sub>2.5</sub>), 1.007 (1.004, 1.011) (PM<sub>10</sub>), 1.008 (1.004, 1.012) (NO<sub>2</sub>), 1.025 (1.007, 1.042) (CO), 1.010 (1.006, 1.013) (O<sub>3</sub>)], except SO<sub>2</sub> [lag0: RR (95% CI), 1.004 (1.000, 1.007); lag1: RR (95% CI), 1.003 (0.999, 1.006)]. Subgroup analyses revealed stronger effects in children and asthma exacerbations associated with other events (including symptoms, lung function changes, and medication use). <b>Conclusion:</b> Outdoor air pollution increases the asthma exacerbation risk in single lag0 and lag1 exposure patterns. <b>Trial registration:</b> PROSPERO, CRD42020204097. https://www.crd.york.ac.uk/. Supplemental data for this article is available online at https://doi.org/10.1080/02770903.2021.2008429 .
DOI: 10.6084/m9.figshare.14463739
title: Challenges for asthma units in response to COVID-19: a qualitative group dynamics analysis

description: To develop a set of recommendations for the management of severe asthma during COVID-19 pandemic. Eleven pneumologists and allergologists who were staff members of officially accredited asthma units in Catalonia (Spain) participated in a cross-section study based on three 2-hour virtual workshops (first: brainstorming, second: identification of impacts and challenges summarized in 10 topics, third: establishment of final recommendations by consensus). Impacts and challenges identified were improvement of referral protocols between different levels of care; assessment of the minimum number of function tests to be performed and promote the performance of spirometry in primary care; implementation of videoconferencing, mobile apps, telephone calls, or integral virtual platforms for the follow-up of patients, and definition of the model of care (face-to-face, telematics, mixed) according to the patient’s individual needs; self-administration of biologics for domiciliary treatment; and empowerment of the role of nursing and hospital pharmacy in particular for follow-up and self-administration of biologics. The main recommendations included coordination between primary care and specialized care consultation, optimization of lung function testing, implementation of telemedicine, and the role of nursing and hospital pharmacy. The specific proposals in response to the effect of COVID-19 pandemic focused on four areas of interest (coordination between primary care and specialized care, optimization of lung function testing, implementation of telemedicine, and empowerment of the role of nursing and hospital pharmacy) may be generalized to other health care settings, and help to introduce new ways of caring asthma patients in the COVID-19 context.
DOI: 10.6084/m9.figshare.14463739.v1
title: Challenges for asthma units in response to COVID-19: a qualitative group dynamics analysis

description: To develop a set of recommendations for the management of severe asthma during COVID-19 pandemic. Eleven pneumologists and allergologists who were staff members of officially accredited asthma units in Catalonia (Spain) participated in a cross-section study based on three 2-hour virtual workshops (first: brainstorming, second: identification of impacts and challenges summarized in 10 topics, third: establishment of final recommendations by consensus). Impacts and challenges identified were improvement of referral protocols between different levels of care; assessment of the minimum number of function tests to be performed and promote the performance of spirometry in primary care; implementation of videoconferencing, mobile apps, telephone calls, or integral virtual platforms for the follow-up of patients, and definition of the model of care (face-to-face, telematics, mixed) according to the patient’s individual needs; self-administration of biologics for domiciliary treatment; and empowerment of the role of nursing and hospital pharmacy in particular for follow-up and self-administration of biologics. The main recommendations included coordination between primary care and specialized care consultation, optimization of lung function testing, implementation of telemedicine, and the role of nursing and hospital pharmacy. The specific proposals in response to the effect of COVID-19 pandemic focused on four areas of interest (coordination between primary care and specialized care, optimization of lung function testing, implementation of telemedicine, and empowerment of the role of nursing and hospital pharmacy) may be generalized to other health care settings, and help to introduce new ways of caring asthma patients in the COVID-19 context.
DOI: 10.6084/m9.figshare.25451413
title: Elnar and Bernido 2024 MatLab Codes

description: These are the codes used to generate the figures in the ma script
DOI: 10.5281/zenodo.10630279
title: Supplementary Tables 1 to 7

description: This dataset combines the supplementary tables generated in the context of our manuscript (Mozin et al.).

Table S1: cell_data file obtained after the initial sciRNA-Seq experiment. The genotype, time point, number of expressed genes and cluster of origin are indicated for each individual cell.

Table S2: Differentially expressed genes (p-adj < 0.0001) obtained after branch expression analysis modeling (BEAM) and the cluster to which they belong on the heatmap shown in Figure 1F.

Table S3: Differentially expressed genes (p-adj < 0.01) detected at Day 10 after sciRNA-Seq.

Table S4: Differentially expressed genes (p-adj < 0.01) detected at Day 10 after split-pool barcoding RNA-Seq.

Table S5: Differentially expressed genes (abs(log2(fold-change)) > 1 & p-adj < 0.01) detected at Day 10 after bulk RNA-Seq in our previous study19.

Table S6: Details of the differentiation experiments performed to obtain Figures 1 to 4.

Table S7: List of barcoded primers used in the RT reaction and in the illumine library preparation of the sciRNA-Seq experiment.
DOI: 10.5281/zenodo.10849178
title: Supplementary Tables 1 to 7

description: This dataset combines the supplementary tables generated in the context of our manuscript (Mozin et al.).

Table S1: cell_data file obtained after the initial sciRNA-Seq experiment. The genotype, time point, number of expressed genes and cluster of origin are indicated for each individual cell.

Table S2: Differentially expressed genes (p-adj < 0.0001) obtained after branch expression analysis modeling (BEAM) and the cluster to which they belong on the heatmap shown in Figure 1F.

Table S3: Differentially expressed genes (p-adj < 0.01) detected at Day 10 after sciRNA-Seq.

Table S4: Details of the differentiation experiments performed to obtain Figures 1 to 4.

Table S5: Differentially expressed genes (p-adj < 0.01) detected at Day 10 after split-pool barcoding RNA-Seq.

Table S6: Differentially expressed genes (abs(log2(fold-change)) > 1 & p-adj < 0.01) detected at Day 10 after bulk RNA-Seq in the study previously published by our group.

Table S7: List of barcoded primers used in the RT reaction and in the illumine library preparation of the sciRNA-Seq experiment.