cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.48597/rerj-mvmu
title: Measurement of Nitrogen oxides at Víznar

description: Measurement of Nitrogen oxides at Víznar
DOI: 10.6084/m9.figshare.14658906
title: MITS in Malawi: Intestinal Data

description: This dataset contains the data used for analyses in "Minimally invasive postmortem intestinal tissue sampling in malnourished and acutely ill children is feasible and informative".
DOI: 10.6084/m9.figshare.16756064
title: Additional file 1 of Map-based cloning and promoter variation analysis of the lobed leaf gene BoLMI1a in ornamental kale (Brassica oleracea L. var. acephala)

description: Additional file 1: Table S1. Details of SNP and InDel variations in the candidate region of BoLl-1.
DOI: 10.6084/m9.figshare.16756064.v1
title: Additional file 1 of Map-based cloning and promoter variation analysis of the lobed leaf gene BoLMI1a in ornamental kale (Brassica oleracea L. var. acephala)

description: Additional file 1: Table S1. Details of SNP and InDel variations in the candidate region of BoLl-1.
DOI: 10.6084/m9.figshare.16756067
title: Additional file 2 of Map-based cloning and promoter variation analysis of the lobed leaf gene BoLMI1a in ornamental kale (Brassica oleracea L. var. acephala)

description: Additional file 2: Table S2. Primer sequences of the markers used in this study.
DOI: 10.3886/5z29-2356
title: Ghana Compact - Financial Services: Design Report (2013)
DOI: 10.3886/r4mr-wn43
title: Ghana Compact - Financial Services: Design Report (2013)
DOI: 10.48597/rwyb-vyf8
title: Measurement of Sum_ammonia_and_ammonium at Hurdal

description: Measurement of Sum_ammonia_and_ammonium at Hurdal
DOI: 10.48597/sawh-3qgd
title: Measurement of Nitrogen_dioxide at Cabo de Creus

description: Measurement of Nitrogen_dioxide at Cabo de Creus
DOI: 10.48597/skjp-82fg
title: Measurement of Nitrogen_dioxide at Niembro

description: Measurement of Nitrogen_dioxide at Niembro
DOI: 10.48597/sps8-kwy5
title: Measurement of Nitrogen_dioxide at Roquetas

description: Measurement of Nitrogen_dioxide at Roquetas
DOI: 10.6084/m9.figshare.7843268.v1
title: Additional file 11: of Comprehensive analysis of dynamic gene expression and investigation of the roles of hydrogen peroxide during adventitious rooting in poplar

description: Table S1. Primers used for RT-qPCR assay. (XLSX 9 kb)
DOI: 10.48597/t6b2-a9cr
title: Measurement of Nitrogen oxides at Víznar

description: Measurement of Nitrogen oxides at Víznar
DOI: 10.48597/t74c-a734
title: Measurement of Nitrogen oxides at Cabo de Creus

description: Measurement of Nitrogen oxides at Cabo de Creus
DOI: 10.6084/m9.figshare.7843274
title: Additional file 1: of Comprehensive analysis of dynamic gene expression and investigation of the roles of hydrogen peroxide during adventitious rooting in poplar

description: Table S2. Genes differentially expressed during poplar AR formation. The numbers indicate FPKM values. (XLSX 507 kb)
DOI: 10.48597/tbav-wq9k
title: Measurement of Nitrogen oxides at Víznar

description: Measurement of Nitrogen oxides at Víznar
DOI: 10.48597/tbkv-fac9
title: Measurement of Nitrogen_dioxide at Campisabalos

description: Measurement of Nitrogen_dioxide at Campisabalos
DOI: 10.6084/m9.figshare.7843274.v1
title: Additional file 1: of Comprehensive analysis of dynamic gene expression and investigation of the roles of hydrogen peroxide during adventitious rooting in poplar

description: Table S2. Genes differentially expressed during poplar AR formation. The numbers indicate FPKM values. (XLSX 507 kb)
DOI: 10.48597/u3am-jkhk
title: Measurement of Precipitation_amount at Turlough Hill

description: Measurement of Precipitation_amount at Turlough Hill
DOI: 10.48597/uryn-gzac
title: Measurement of Nitrogen oxides at Cabo de Creus

description: Measurement of Nitrogen oxides at Cabo de Creus
DOI: 10.48597/v99z-xfpg
title: Measurement of Nitrogen_dioxide at Noia

description: Measurement of Nitrogen_dioxide at Noia
DOI: 10.48597/vkgw-3c9t
title: Measurement of Sulphur_dioxide at Noia

description: Measurement of Sulphur_dioxide at Noia
DOI: 10.48597/vv9x-xpz5
title: Measurement of Nitrogen_dioxide at Niembro

description: Measurement of Nitrogen_dioxide at Niembro
DOI: 10.48597/w3vf-rqjc
title: Measurement of Inorganics in air and particle phase at Risco Llamo

description: Measurement of Inorganics in air and particle phase at Risco Llamo
DOI: 10.48597/w6as-ctu8
title: Measurement of Nitrogen_dioxide at Víznar

description: Measurement of Nitrogen_dioxide at Víznar
DOI: 10.48597/wan3-8uvu
title: Measurement of Nitrogen_dioxide at Víznar

description: Measurement of Nitrogen_dioxide at Víznar
DOI: 10.48597/wkq2-ujp8
title: Measurement of Sum_ammonia_and_ammonium at Hurdal

description: Measurement of Sum_ammonia_and_ammonium at Hurdal
DOI: 10.48597/wtts-9j76
title: Measurement of Nitrogen oxides at Niembro

description: Measurement of Nitrogen oxides at Niembro
DOI: 10.48597/wuu5-suey
title: Measurement of Nitrogen_dioxide at Campisabalos

description: Measurement of Nitrogen_dioxide at Campisabalos
DOI: 10.48597/wxyj-nc8v
title: Measurement of Nitrogen oxides at Víznar

description: Measurement of Nitrogen oxides at Víznar
DOI: 10.48597/x7z9-fq9r
title: Measurement of Nitrogen_dioxide at Noia

description: Measurement of Nitrogen_dioxide at Noia
DOI: 10.6084/m9.figshare.7843286.v1
title: Additional file 4: of Comprehensive analysis of dynamic gene expression and investigation of the roles of hydrogen peroxide during adventitious rooting in poplar

description: Table S3. Phytohormone-related genes in poplar (XLSX 30 kb)
DOI: 10.48597/xh8u-8zqs
title: Measurement of Inorganics in air and particle phase at Barcarrota

description: Measurement of Inorganics in air and particle phase at Barcarrota
DOI: 10.5523/bris.mz85vyusop082j481j2ddl1rf
title: Athavan_AppliedPhysicsLetters2024

description: Copies of coordinate files (in xyz format) for the calculated structure
DOI: 10.48597/xj7a-pf4d
title: Measurement of Inorganics in air and particle phase at Zarra

description: Measurement of Inorganics in air and particle phase at Zarra
DOI: 10.48597/xpws-hbeq
title: Measurement of Inorganics in air and particle phase at Zarra

description: Measurement of Inorganics in air and particle phase at Zarra
DOI: 10.48597/yb6b-bvm8
title: Measurement of Sum_ammonia_and_ammonium at Svanvik

description: Measurement of Sum_ammonia_and_ammonium at Svanvik
DOI: 10.48597/ypnu-ye22
title: Measurement of Inorganics in air and particle phase at Barcarrota

description: Measurement of Inorganics in air and particle phase at Barcarrota
DOI: 10.48597/yuuy-xu6f
title: Measurement of Nitrogen_dioxide at San Pablo de los Montes

description: Measurement of Nitrogen_dioxide at San Pablo de los Montes
DOI: 10.48597/z3x9-d8vf
title: Measurement of Sum_ammonia_and_ammonium at Svanvik

description: Measurement of Sum_ammonia_and_ammonium at Svanvik
DOI: 10.48597/zhkd-c9pq
title: Measurement of Nitrogen oxides at Cabo de Creus

description: Measurement of Nitrogen oxides at Cabo de Creus
DOI: 10.48597/2aq7-mrna
title: Measurement of Nickel at Storhofdi

description: Measurement of Nickel at Storhofdi
DOI: 10.48597/2bhb-afvm
title: Measurement of Benzo_ghi_perylene at Kollumerwaard

description: Measurement of Benzo_ghi_perylene at Kollumerwaard
DOI: 10.48597/2cvj-wxpm
title: Measurement of Sodium at Bilthoven

description: Measurement of Sodium at Bilthoven
DOI: 10.48597/2j47-78e9
title: Measurement of Nitrogen_monoxide at Cabauw Wielsekade

description: Measurement of Nitrogen_monoxide at Cabauw Wielsekade
DOI: 10.48597/2jd7-bjy7
title: Measurement of Conductivity at De Zilk

description: Measurement of Conductivity at De Zilk
DOI: 10.48597/2vu5-nkd9
title: Measurement of Vanadium at Storhofdi

description: Measurement of Vanadium at Storhofdi
DOI: 10.48597/32er-t9mm
title: Measurement of Sulphate_total at De Zilk

description: Measurement of Sulphate_total at De Zilk
DOI: 10.48597/38zx-fxhx
title: Measurement of Sodium at Kollumerwaard

description: Measurement of Sodium at Kollumerwaard
DOI: 10.48597/3dxn-ebwz
title: Measurement of Sodium at Vredepeel

description: Measurement of Sodium at Vredepeel
DOI: 10.48597/3e9n-4jea
title: Measurement of Precipitation_amount at De Zilk

description: Measurement of Precipitation_amount at De Zilk
DOI: 10.48597/3h4e-hft9
title: Measurement of Pm25_mass at De Zilk

description: Measurement of Pm25_mass at De Zilk
DOI: 10.48597/3k7n-8m9v
title: Measurement of Zinc at Vredepeel

description: Measurement of Zinc at Vredepeel
DOI: 10.48597/3sau-wfac
title: Measurement of Copper at Vredepeel

description: Measurement of Copper at Vredepeel
DOI: 10.48597/4373-gm9v
title: Measurement of Organic_carbon at Cabauw Wielsekade

description: Measurement of Organic_carbon at Cabauw Wielsekade
DOI: 10.48597/49qa-w8h6
title: Measurement of Pm10_mass at Cabauw Wielsekade

description: Measurement of Pm10_mass at Cabauw Wielsekade
DOI: 10.48597/4mfz-ztt8
title: Measurement of Iron at Vredepeel

description: Measurement of Iron at Vredepeel
DOI: 10.48597/4rkk-3p8k
title: Measurement of Benzo_a_pyrene at Kollumerwaard

description: Measurement of Benzo_a_pyrene at Kollumerwaard
DOI: 10.48597/4w23-jzrx
title: Measurement of Arsenic at De Zilk

description: Measurement of Arsenic at De Zilk
DOI: 10.48597/52th-k354
title: Measurement of Nickel at De Zilk

description: Measurement of Nickel at De Zilk
DOI: 10.6084/m9.figshare.7843322
title: Additional file 9: of Comprehensive analysis of dynamic gene expression and investigation of the roles of hydrogen peroxide during adventitious rooting in poplar

description: Table S5. Functional enrichment of genes in the 12 clusters. (XLSX 15 kb)
DOI: 10.48597/5mrj-79fd
title: Measurement of Zinc at Kollumerwaard

description: Measurement of Zinc at Kollumerwaard
DOI: 10.48597/6qgr-hnxz
title: Measurement of Nitrogen_dioxide at Eibergen

description: Measurement of Nitrogen_dioxide at Eibergen
DOI: 10.6084/m9.figshare.7843322.v1
title: Additional file 9: of Comprehensive analysis of dynamic gene expression and investigation of the roles of hydrogen peroxide during adventitious rooting in poplar

description: Table S5. Functional enrichment of genes in the 12 clusters. (XLSX 15 kb)
DOI: 10.48597/7c9j-9q38
title: Measurement of Nitrogen oxides at Vredepeel

description: Measurement of Nitrogen oxides at Vredepeel
DOI: 10.48597/7jxn-fhjv
title: Measurement of Chloride at De Zilk

description: Measurement of Chloride at De Zilk
DOI: 10.48597/7q5a-h52v
title: Measurement of Nitrogen oxides at De Zilk

description: Measurement of Nitrogen oxides at De Zilk
DOI: 10.48597/7z4g-8rvp
title: Measurement of Ammonium at De Zilk

description: Measurement of Ammonium at De Zilk
DOI: 10.48597/82gu-fxy6
title: Measurement of Pm10_mass at Vredepeel

description: Measurement of Pm10_mass at Vredepeel
DOI: 10.48597/83fq-zpym
title: Measurement of Calcium at Kollumerwaard

description: Measurement of Calcium at Kollumerwaard
DOI: 10.48597/89ud-mzgq
title: Measurement of Sulphur_dioxide at Cabauw Wielsekade

description: Measurement of Sulphur_dioxide at Cabauw Wielsekade
DOI: 10.48597/8eu2-3k3w
title: Measurement of Arsenic at Bilthoven

description: Measurement of Arsenic at Bilthoven
DOI: 10.48597/8v4k-4jpq
title: Measurement of Nitrogen_monoxide at Vredepeel

description: Measurement of Nitrogen_monoxide at Vredepeel
DOI: 10.48597/9eas-n7yx
title: Measurement of Precipitation_amount at Reykjavik

description: Measurement of Precipitation_amount at Reykjavik
DOI: 10.48597/a7yk-2mvx
title: Measurement of Arsenic at Vredepeel

description: Measurement of Arsenic at Vredepeel
DOI: 10.48597/ah34-gzkv
title: Measurement of Pm10_mass at De Zilk

description: Measurement of Pm10_mass at De Zilk
DOI: 10.48597/anhv-7nru
title: Measurement of Nickel at Vredepeel

description: Measurement of Nickel at Vredepeel
DOI: 10.48597/b3wx-a2u3
title: Measurement of Lead at Kollumerwaard

description: Measurement of Lead at Kollumerwaard
DOI: 10.5258/soton/d2972
title: Dataset supporting the University of Southampton Doctoral Thesis "Exploring social anxiety in digital platforms within novel experimental laboratory paradigms"

description: Dataset supporting the University of Southampton Doctoral Thesis "Exploring social anxiety in digital platforms within novel experimental laboratory paradigms".

The dataset includes all data that were used in the thesis, for Chapters 2, 3, and 4:

Chapter2_HR_imputedforCCC_copy.csv
 
Chapter2_co2labdata_sum1.csv
Participant response input was recorded using the Oculus Rift Bluetooth touch controller.

Chapter2_screening_data.csv
This data is collected via telephone. 

Chapter3_pro_data_sum.csv
Participant response input was recorded using the Oculus Rift Bluetooth touch controller.

Chapter4_OnlineTrierdata_eligible_121.csv
The videoconferencing session took place on Blackboard Collaborate (https://ca.bbcollab.com/). 

Chapter4_OnlineTrierdata_full.csv
Data were collected via Qualtrics. 

The data is accessible via CC BY licence
DOI: 10.48597/b4es-3e8h
title: Measurement of Vanadium at Reykjavik

description: Measurement of Vanadium at Reykjavik
DOI: 10.48597/bhn9-4xe8
title: Measurement of Ammonium at De Zilk

description: Measurement of Ammonium at De Zilk
DOI: 10.48597/bjsb-6e6w
title: Measurement of Nitrate at De Zilk

description: Measurement of Nitrate at De Zilk
DOI: 10.48597/bm8y-zxsg
title: Measurement of Zinc at Reykjavik

description: Measurement of Zinc at Reykjavik
DOI: 10.48597/bqqz-zrnn
title: Measurement of Aluminium at Storhofdi

description: Measurement of Aluminium at Storhofdi
DOI: 10.6084/m9.figshare.19901958
title: Preparation of SAPO-34-Based Catalyst for Conversion of Fructose to 5-Hydroxymethylfurfural

description: Solid acid-catalyzed dehydration of fructose to produce 5-hydroxymethylfurfural (5-HMF) has been a hotspot in biomass conversion research in recent years. In this study, a novel SAPO-34-based catalyst was prepared by consecutive steps of titanium doping, sulfuric acid impregnation, and sulfonic acid functionalization. Characterization of the catalyst with X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), BrunauerEmmett-Teller (BET), inductively coupled plasma optical emission spectrometer (ICP-OES), and acid-base titration revealed different pore structures and more acid content compared to SAPO-34. The catalyst was applied to the preparation of 5-HMF by dehydration of fructose, and the maximum yield (74.0%) of 5-HMF was obtained by reacting in dimethyl sulfoxide (DMSO) at 170 °C for 50 min. In addition, the applicability of the catalytic system to other substrates and the stability of the catalyst after five cycles were investigated, which are valuable for further probing on the concerned aspects.
DOI: 10.48597/c49f-udd9
title: Measurement of Cobalt at Storhofdi

description: Measurement of Cobalt at Storhofdi
DOI: 10.48597/cq85-czjm
title: Measurement of Vanadium at De Zilk

description: Measurement of Vanadium at De Zilk
DOI: 10.48597/dg94-6s5m
title: Measurement of Nickel at Bilthoven

description: Measurement of Nickel at Bilthoven
DOI: 10.6084/m9.figshare.19901958.v1
title: Preparation of SAPO-34-Based Catalyst for Conversion of Fructose to 5-Hydroxymethylfurfural

description: Solid acid-catalyzed dehydration of fructose to produce 5-hydroxymethylfurfural (5-HMF) has been a hotspot in biomass conversion research in recent years. In this study, a novel SAPO-34-based catalyst was prepared by consecutive steps of titanium doping, sulfuric acid impregnation, and sulfonic acid functionalization. Characterization of the catalyst with X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), BrunauerEmmett-Teller (BET), inductively coupled plasma optical emission spectrometer (ICP-OES), and acid-base titration revealed different pore structures and more acid content compared to SAPO-34. The catalyst was applied to the preparation of 5-HMF by dehydration of fructose, and the maximum yield (74.0%) of 5-HMF was obtained by reacting in dimethyl sulfoxide (DMSO) at 170 °C for 50 min. In addition, the applicability of the catalytic system to other substrates and the stability of the catalyst after five cycles were investigated, which are valuable for further probing on the concerned aspects.
DOI: 10.48597/dqag-v6y7
title: Measurement of Nitrogen_dioxide at Vredepeel

description: Measurement of Nitrogen_dioxide at Vredepeel
DOI: 10.48597/efgj-x2yh
title: Measurement of Manganese at Storhofdi

description: Measurement of Manganese at Storhofdi
DOI: 10.48597/eksq-6dkk
title: Measurement of Nickel at Vredepeel

description: Measurement of Nickel at Vredepeel
DOI: 10.48597/ese9-a4ns
title: Measurement of Benzo_ghi_perylene at De Zilk

description: Measurement of Benzo_ghi_perylene at De Zilk
DOI: 10.48597/ev3c-v4xv
title: Measurement of Nitrogen oxides at Kollumerwaard

description: Measurement of Nitrogen oxides at Kollumerwaard
DOI: 10.48597/fuda-uc9z
title: Measurement of Vanadium at Vredepeel

description: Measurement of Vanadium at Vredepeel
DOI: 10.48597/fyxc-z2bd
title: Measurement of Copper at De Zilk

description: Measurement of Copper at De Zilk
DOI: 10.48597/g953-zf7r
title: Measurement of Ammonia at De Zilk

description: Measurement of Ammonia at De Zilk
DOI: 10.48597/gg8h-n67n
title: Measurement of Nitrogen_monoxide at De Zilk

description: Measurement of Nitrogen_monoxide at De Zilk
DOI: 10.48597/gsuz-pey6
title: Measurement of Carbon_monoxide at Cabauw Wielsekade

description: Measurement of Carbon_monoxide at Cabauw Wielsekade
DOI: 10.48597/h6av-3evq
title: Measurement of Precipitation_amount at De Zilk

description: Measurement of Precipitation_amount at De Zilk
DOI: 10.48597/hc9x-7s5w
title: Measurement of Potassium at De Zilk

description: Measurement of Potassium at De Zilk
DOI: 10.48597/hcff-v2jh
title: Measurement of Acidity at De Zilk

description: Measurement of Acidity at De Zilk
DOI: 10.48597/hp83-rw89
title: Measurement of Sulphur_dioxide at De Zilk

description: Measurement of Sulphur_dioxide at De Zilk
DOI: 10.48597/htec-bupj
title: Measurement of Nitrogen oxides at Cabauw Wielsekade

description: Measurement of Nitrogen oxides at Cabauw Wielsekade
DOI: 10.48597/j58n-att8
title: Measurement of Magnesium at Kollumerwaard

description: Measurement of Magnesium at Kollumerwaard
DOI: 10.48597/j887-huxm
title: Measurement of Chrysene at De Zilk

description: Measurement of Chrysene at De Zilk
DOI: 10.48597/jfsa-qur5
title: Measurement of Lead at Reykjavik

description: Measurement of Lead at Reykjavik
DOI: 10.48597/jqje-xgp6
title: Measurement of Cadmium at Kollumerwaard

description: Measurement of Cadmium at Kollumerwaard
DOI: 10.48597/k23v-s7t5
title: Measurement of Nitrate at De Zilk

description: Measurement of Nitrate at De Zilk
DOI: 10.48597/m66g-6u99
title: Measurement of Nitrogen_monoxide at Eibergen

description: Measurement of Nitrogen_monoxide at Eibergen
DOI: 10.48597/mag9-p97z
title: Measurement of Calcium at Bilthoven

description: Measurement of Calcium at Bilthoven
DOI: 10.48597/mh3g-zse2
title: Measurement of Cadmium at Vredepeel

description: Measurement of Cadmium at Vredepeel
DOI: 10.6084/m9.figshare.7843388
title: Additional file 11: of In-depth transcriptome characterization uncovers distinct gene family expansions for Cupressus gigantea important to this long-lived speciesâ adaptability to environmental cues

description: Table S6. KEGG pathway annotations for the assembled unigenes. (XLSX 173 kb)
DOI: 10.48597/mxhs-qkmx
title: Measurement of Nitrogen_monoxide at Kollumerwaard

description: Measurement of Nitrogen_monoxide at Kollumerwaard
DOI: 10.48597/nke4-u32s
title: Measurement of Chromium at Storhofdi

description: Measurement of Chromium at Storhofdi
DOI: 10.6084/m9.figshare.7843388.v1
title: Additional file 11: of In-depth transcriptome characterization uncovers distinct gene family expansions for Cupressus gigantea important to this long-lived speciesâ adaptability to environmental cues

description: Table S6. KEGG pathway annotations for the assembled unigenes. (XLSX 173 kb)
DOI: 10.48597/nuhr-ynyd
title: Measurement of Zinc at Vredepeel

description: Measurement of Zinc at Vredepeel
DOI: 10.48597/nz7h-eg95
title: Measurement of Arsenic at Vredepeel

description: Measurement of Arsenic at Vredepeel
DOI: 10.48597/pc87-33va
title: Measurement of Magnesium at De Zilk

description: Measurement of Magnesium at De Zilk
DOI: 10.6084/m9.figshare.15183435
title: Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in <i>TGFBI</i> (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy

description: Thiel-Behnke corneal dystrophy (TBCD) is an epithelial-stromal <i>TGFBI</i> dystrophy caused by mutations in the <i>TGFBI</i> (transforming growth factor beta induced) gene, though the underlying mechanisms and pathogenesis of TBCD are still obscure. The study identifies a novel mutation in the <i>TGFBI</i> gene (p.Gly623_His626del) in a TBCD pedigree. Characteristics of the typical vacuole formation, irregular corneal epithelial thickening and thinning, deposition of eosinophilic substances beneath the epithelium, and involvement of the anterior stroma were observed in this pedigree via transmission electron microscopy (TEM) and histological staining. <i>Tgfbi</i>-p.Gly623_Tyr626del mouse models of TBCD were subsequently generated via CRISPR/Cas9 technology, and the above characteristics were further verified via TEM and histological staining. Lysosomal dysfunction and downregulation of differential expression protein CTSD (cathepsin D) were observed using LysoTracker Green DND-26 and proteomic analysis, respectively. Hence, lysosomal dysfunction probably leads to autophagic flux obstruction in TBCD; this was supported by enhanced LC3-II and SQSTM1 levels and decreased CTSD. TFEB (transcription factor EB) was prominently decreased in TBCD corneal fibroblasts and administration of ATP-competitive MTOR inhibitor torin 1 reversed this decline, resulting in the degradation of accumulated mut-TGFBI (mutant TGFBI protein) via the ameliorative lysosomal function and autophagic flux owing to elevated TFEB activity as measured by western blot, confocal microscopy, and flow cytometry. Transfected HEK 293 cells overexpressing human full-length WT-<i>TGFBI</i> and mut-<i>TGFBI</i> were generated to further verify the results obtained in human corneal fibroblasts. Amelioration of lysosome dysfunction may therefore have therapeutic efficacy in the treatment of TBCD. <b>Abbreviations</b> AS-OCT: anterior segment optical coherence tomography; ATP: adenosine triphosphate; Cas9: CRISPR-associated protein 9; CLEAR: coordinated lysosomal expression and regulation; CRISPR: clustered regularly interspaced short palindromic repeats; CTSB: cathepsin B; CTSD: cathepsin D; CTSF: cathepsin F; CTSL: cathepsin L; DNA: deoxyribonucleic acid; ECM: extracellular matrix; Fas1: fasciclin 1; FC: flow cytometry; GAPDH: glyceraldeyde-3-phosphate dehydrogenase; GCD2: granular corneal dystrophy type 2; HE: hematoxylin and eosin; LAMP2: lysosomal-associated membrane protein; MT: mutation type; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; mut-TGFBI: mutant TGFBI protein; SD: standard deviation; TBCD: Thiel-Behnke corneal dystrophy; TEM: transmission electron microscopy; TFEB: transcription factor EB; TGFBI: transforming growth factor beta induced; WT: wild type