cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19923625.v1
title: A modelling approach to simulate Chlorophyta and Cyanobacteria biomasses based on historical data of a Brazilian urban reservoir

description: Abstract A process-based model was used to simulate a hindcast based on the worst historical water quality condition of a tropical urban reservoir. Paranoá Lake is located in Brasília-DF, Brazil, and went through intense eutrophication in the 70s and 90s, with an important cyanobacterial bloom event in 1978. The parameters of phytoplankton were calibrated, focusing on the group of Chlorophyta (green algae) and Cyanobacteria (blue-green algae) at four depths (1, 10, 15 and 20m). The results indicated that the model was able to reproduce the Cyanobacteria biomass in comparison with the observations (RMSE=22-29.10-3 mgC L-1). On the other hand, the simulated Chlorophyta biomass showed good agreement with the observed data only in the bottom layer (RMSE=29. 10-3 mgC L-1 at 20m). In the hindcast simulation, the model was able to predict a significant increase in cyanobacterial biomass facing a water quality deterioration. In the meantime, the simulated Chlorophyta biomass decreased, which may indicate the phytoplankton group succession in response to the environmental conditions.
DOI: 10.6084/m9.figshare.19923624.v1
title: Management of acute appendicitis during the COVID-19 pandemic: Views of two Brazilian surgical societies

description: ABSTRACT Acute appendicitis (AA) is a frequent cause of abdominal pain requiring surgical treatment. During the COVID-19 pandemic, surgical societies considered other therapeutic options due to uncertainties in the evolution of the disease. The purpose of this study is to assess the treatment of AA by members of two Brazilian surgical societies in this period. A common questionnaire was sent in 2020. There were 382 responses. Most surgeons had more than 15 years of profession (68.3%) and treated more than five cases per month (44.8%). About 72.5% would indicate chest CT to investigate COVID-19 in patients with AA. For those patients sustaining uncomplicated AA, without COVID-19, 60.2% would indicate laparoscopic appendectomy (VLA), followed by open appendectomy (OA) (31.7%) and non-operative management (NOM) (1.3%). For those with mild COVID-19, OA was suggested by 51.0%, followed by VLA (29.6%) and NOM (6.0%). For those with severe COVID-19, OA was proposed by 35.3%, followed by NOM (19.9%) and VLA (18.6%). For patients with periappendiceal abscesses, without COVID-19, VLA was suggested by 54.2%, followed by OA (33.2%) and NOM (4.4%). For those with mild COVID-19, OA was proposed in 49.5%, followed by VLA (29.3%) and NOM (8.9%). In those with severe COVID-19, OA was proposed in 36.6%, followed by NOM (25.1%) and VLA (17.3%). This information, based on two recognized Brazilian surgical societies, can help the surgeon to select the best approach individually.
DOI: 10.6084/m9.figshare.19923624
title: Management of acute appendicitis during the COVID-19 pandemic: Views of two Brazilian surgical societies

description: ABSTRACT Acute appendicitis (AA) is a frequent cause of abdominal pain requiring surgical treatment. During the COVID-19 pandemic, surgical societies considered other therapeutic options due to uncertainties in the evolution of the disease. The purpose of this study is to assess the treatment of AA by members of two Brazilian surgical societies in this period. A common questionnaire was sent in 2020. There were 382 responses. Most surgeons had more than 15 years of profession (68.3%) and treated more than five cases per month (44.8%). About 72.5% would indicate chest CT to investigate COVID-19 in patients with AA. For those patients sustaining uncomplicated AA, without COVID-19, 60.2% would indicate laparoscopic appendectomy (VLA), followed by open appendectomy (OA) (31.7%) and non-operative management (NOM) (1.3%). For those with mild COVID-19, OA was suggested by 51.0%, followed by VLA (29.6%) and NOM (6.0%). For those with severe COVID-19, OA was proposed by 35.3%, followed by NOM (19.9%) and VLA (18.6%). For patients with periappendiceal abscesses, without COVID-19, VLA was suggested by 54.2%, followed by OA (33.2%) and NOM (4.4%). For those with mild COVID-19, OA was proposed in 49.5%, followed by VLA (29.3%) and NOM (8.9%). In those with severe COVID-19, OA was proposed in 36.6%, followed by NOM (25.1%) and VLA (17.3%). This information, based on two recognized Brazilian surgical societies, can help the surgeon to select the best approach individually.
DOI: 10.6084/m9.figshare.19923627
title: Assay of empagliflozin tablets by a stability-indicating micellar electrokinetic chromatography method and cytotoxicity study of degraded samples

description: The first method by micellar electrokinetic chromatography (MEKC) for the determination of empagliflozin in tablets was developed and validated following the ICH guidelines. The separation was achieved in a fused silica capillary with 50 µm x 40 cm (inner diameter x effective length) at 28 ºC, +28 kV voltage, hydrodynamic injection 4s (50 mBar), detection at 225 nm and paracetamol was the internal standard. The running electrolyte was a mixture of 20 mM tris(hydroxymethyl)aminomethane (pH 10) and 100 mM sodium dodecyl sulphate (1:1). Specificity was evaluated by the stress testing and the method was specific, with no interference of the degradation product. Linearity was observed in the range of 50 to 150 μg/mL (r=0.9999). The method showed adequate accuracy (recovery value=100.60±0.60%), precision (RSD values &lt;2%) and robustness, which was evaluated by a full factorial design 23. Drug degradation kinetics was evaluated in alkaline and acidic conditions and first-order kinetic was observed in both conditions. The cytotoxicity of sample solutions degraded by UVA and UVC radiation, alkaline and acid media were studied as well. A similar cellular viability profile was observed with a slight decrease only in samples degraded by UVC radiation and basic medium
DOI: 10.6084/m9.figshare.19923627.v1
title: Assay of empagliflozin tablets by a stability-indicating micellar electrokinetic chromatography method and cytotoxicity study of degraded samples

description: The first method by micellar electrokinetic chromatography (MEKC) for the determination of empagliflozin in tablets was developed and validated following the ICH guidelines. The separation was achieved in a fused silica capillary with 50 µm x 40 cm (inner diameter x effective length) at 28 ºC, +28 kV voltage, hydrodynamic injection 4s (50 mBar), detection at 225 nm and paracetamol was the internal standard. The running electrolyte was a mixture of 20 mM tris(hydroxymethyl)aminomethane (pH 10) and 100 mM sodium dodecyl sulphate (1:1). Specificity was evaluated by the stress testing and the method was specific, with no interference of the degradation product. Linearity was observed in the range of 50 to 150 μg/mL (r=0.9999). The method showed adequate accuracy (recovery value=100.60±0.60%), precision (RSD values &lt;2%) and robustness, which was evaluated by a full factorial design 23. Drug degradation kinetics was evaluated in alkaline and acidic conditions and first-order kinetic was observed in both conditions. The cytotoxicity of sample solutions degraded by UVA and UVC radiation, alkaline and acid media were studied as well. A similar cellular viability profile was observed with a slight decrease only in samples degraded by UVC radiation and basic medium
DOI: 10.6084/m9.figshare.19923630
title: Use of toxic bait to manage the south american fruit fly in apple orchards in Southern Brazil

description: Abstract Anastrepha fraterculus the South American fruit fly, is an important insect pest in apple orchards of southern Brazil, especially in small farms, where it often causes total crop loss. Experiments were conducted to evaluate, during four crop seasons (2009/2010, 2010/2011, 2012/2013, and 2013/2014) in organic and conventional apple orchards in southern Brazil, the toxic bait formulation ANAMED™ (oils and waxes 49.0% + M7 attractant 24.2% + spinosad insecticide 0.1%) for its capacity to reduce the South American fruit fly population. ANAMED applications started after apples with an average diameter of 20 mm had been thinned, and they were made every 14 days until harvest. ANAMED was sprayed on non-crop vegetation growing on the edges of the orchards at a rate of 1.0 kg.ha-1. Adult fruit flies were monitored weekly using McPhail traps baited with Torula™ yeast. Injured fruits were evaluated seven days before harvest. ANAMED reduced the adult population of trapped fruit flies captured in all crop seasons and the injured fruit, except for the first year of evaluation (2009/2010). In conclusion, the sequential use of ANAMED toxic bait over time significantly reduced adult populations of A. fraterculus and the percentage of fruits injured by this pest.
DOI: 10.6084/m9.figshare.19923630.v1
title: Use of toxic bait to manage the south american fruit fly in apple orchards in Southern Brazil

description: Abstract Anastrepha fraterculus the South American fruit fly, is an important insect pest in apple orchards of southern Brazil, especially in small farms, where it often causes total crop loss. Experiments were conducted to evaluate, during four crop seasons (2009/2010, 2010/2011, 2012/2013, and 2013/2014) in organic and conventional apple orchards in southern Brazil, the toxic bait formulation ANAMED™ (oils and waxes 49.0% + M7 attractant 24.2% + spinosad insecticide 0.1%) for its capacity to reduce the South American fruit fly population. ANAMED applications started after apples with an average diameter of 20 mm had been thinned, and they were made every 14 days until harvest. ANAMED was sprayed on non-crop vegetation growing on the edges of the orchards at a rate of 1.0 kg.ha-1. Adult fruit flies were monitored weekly using McPhail traps baited with Torula™ yeast. Injured fruits were evaluated seven days before harvest. ANAMED reduced the adult population of trapped fruit flies captured in all crop seasons and the injured fruit, except for the first year of evaluation (2009/2010). In conclusion, the sequential use of ANAMED toxic bait over time significantly reduced adult populations of A. fraterculus and the percentage of fruits injured by this pest.
DOI: 10.6084/m9.figshare.19923631
title: “How do I go to research alone?” The insert process in post-graduation evidenced in narratives of a teacher

description: ABSTRACT This work is the result of an investigation that aims to understand the processes of insertion of teachers in higher education in federal universities, in a longitudinal perspective. In this (self) biographical article, we analyze the insertion processes of a teacher, based on her narratives, during the first years of the profession, from 2016 to 2020. The interpretive look of these reports falls to how, in each written narrative, the lived experiences are being remembered, in a “coming and going” of temporality. We emphasize the reflection on the insertion in teaching and post-graduation, specifically in research and guidance activities. The results showed tensions in relation to the complexity of professional practice in the university context. The (re) told story of the transition period in the probationary stage brings elements that mark the process of teacher identity constitution, and reinforces the perception about how interactive processes are propellers of new possibilities of performance and insertion of teachers in graduate school.
DOI: 10.6084/m9.figshare.19923631.v1
title: “How do I go to research alone?” The insert process in post-graduation evidenced in narratives of a teacher

description: ABSTRACT This work is the result of an investigation that aims to understand the processes of insertion of teachers in higher education in federal universities, in a longitudinal perspective. In this (self) biographical article, we analyze the insertion processes of a teacher, based on her narratives, during the first years of the profession, from 2016 to 2020. The interpretive look of these reports falls to how, in each written narrative, the lived experiences are being remembered, in a “coming and going” of temporality. We emphasize the reflection on the insertion in teaching and post-graduation, specifically in research and guidance activities. The results showed tensions in relation to the complexity of professional practice in the university context. The (re) told story of the transition period in the probationary stage brings elements that mark the process of teacher identity constitution, and reinforces the perception about how interactive processes are propellers of new possibilities of performance and insertion of teachers in graduate school.
DOI: 10.6084/m9.figshare.19923633
title: Calibration of hydrometer for cold water of nominal flow of 1,5 m3/h

description: ABSTRACT With the current water crisis, water companies have been joining efforts to find solutions to reduce water losses. In a water supply system, there can be two types of losses, the real ones — caused by pipe leaks, tank leaks, and overflows in the reservoirs — and the apparent losses — caused by fraud, illegal connections, and metering inaccuracies. The periodic monitoring of the metrological reliability of the water meters through calibration allows supporting the decision on whether or not to change these water meters, thus reducing apparent losses. Therefore, this paper presented a method for calibrating the cold water, tachometer, monojate, class B water meters, with a nominal flow rate of 1.5 m3/h, the most commonly used type of meter for residential connections, through the INMETRO Ordinance No. 246, October 17, 2000. The proposed method presents the conditions for meter and bench preparation, the measurement system, the possible sources of errors, and their associated uncertainties. In addition to the measurement uncertainty calculation method, as recommended by the ISO Guideline for Measurement Uncertainty Expression (GUM), published in 2008. Three water meters in use, from the Pernambuco water company (COMPESA), manufactured in 2015, 2016, and 2017, were calibrated using the proposed method and bench. The results obtained demonstrate the viability of the method to support the change of water meters in the comparative analysis between INMETRO reference values and the measured value corrected with uncertainties.
DOI: 10.6084/m9.figshare.19923633.v1
title: Calibration of hydrometer for cold water of nominal flow of 1,5 m3/h

description: ABSTRACT With the current water crisis, water companies have been joining efforts to find solutions to reduce water losses. In a water supply system, there can be two types of losses, the real ones — caused by pipe leaks, tank leaks, and overflows in the reservoirs — and the apparent losses — caused by fraud, illegal connections, and metering inaccuracies. The periodic monitoring of the metrological reliability of the water meters through calibration allows supporting the decision on whether or not to change these water meters, thus reducing apparent losses. Therefore, this paper presented a method for calibrating the cold water, tachometer, monojate, class B water meters, with a nominal flow rate of 1.5 m3/h, the most commonly used type of meter for residential connections, through the INMETRO Ordinance No. 246, October 17, 2000. The proposed method presents the conditions for meter and bench preparation, the measurement system, the possible sources of errors, and their associated uncertainties. In addition to the measurement uncertainty calculation method, as recommended by the ISO Guideline for Measurement Uncertainty Expression (GUM), published in 2008. Three water meters in use, from the Pernambuco water company (COMPESA), manufactured in 2015, 2016, and 2017, were calibrated using the proposed method and bench. The results obtained demonstrate the viability of the method to support the change of water meters in the comparative analysis between INMETRO reference values and the measured value corrected with uncertainties.
DOI: 10.6084/m9.figshare.19923634
title: Evaluation of physicochemical and microbiological stability of liquid preparation from tizanidine hydrochloride tablets - a Hospital concern

description: Tizanidine hydrochloride is a centrally acting skeletal muscle relaxant, used in the management of spasticity. This drug is commercially available only as tablets, which highlights the need to develop oral liquid formulations. In the hospital environment, this aspect is circumvented by the preparation of suspensions, to allow administration to children and adults with impaired swallowing, but there are no data regarding their stability. The purpose of this study was to evaluate the physicochemical andmicrobiological stability of liquid dosage forms prepared in the hospital environment from tizanidine hydrochloride tablets, applying high performance liquid chromatography (HPLC) and microbiological analysis. A simple and stability-indicating HPLC method was developed and validated for specificity, linearity, limits of detection and quantification, precision, accuracy and robustness. The liquid formulations were placed in amber PET and glass bottles, which were stored under three different conditions: at room temperature, under refrigeration and at 40 ºC. The liquid formulations were analyzed and demonstrated chemical stability for 56 days, allowing their use for long periods. However, the determination of microbiological stability showed that these formulations are prone to microbial contamination, which has dramatically reduced its stability to 7 days, in both bottles and at all evaluated temperatures
DOI: 10.6084/m9.figshare.19923634.v1
title: Evaluation of physicochemical and microbiological stability of liquid preparation from tizanidine hydrochloride tablets - a Hospital concern

description: Tizanidine hydrochloride is a centrally acting skeletal muscle relaxant, used in the management of spasticity. This drug is commercially available only as tablets, which highlights the need to develop oral liquid formulations. In the hospital environment, this aspect is circumvented by the preparation of suspensions, to allow administration to children and adults with impaired swallowing, but there are no data regarding their stability. The purpose of this study was to evaluate the physicochemical andmicrobiological stability of liquid dosage forms prepared in the hospital environment from tizanidine hydrochloride tablets, applying high performance liquid chromatography (HPLC) and microbiological analysis. A simple and stability-indicating HPLC method was developed and validated for specificity, linearity, limits of detection and quantification, precision, accuracy and robustness. The liquid formulations were placed in amber PET and glass bottles, which were stored under three different conditions: at room temperature, under refrigeration and at 40 ºC. The liquid formulations were analyzed and demonstrated chemical stability for 56 days, allowing their use for long periods. However, the determination of microbiological stability showed that these formulations are prone to microbial contamination, which has dramatically reduced its stability to 7 days, in both bottles and at all evaluated temperatures
DOI: 10.6084/m9.figshare.19923636
title: Olfactory dysfunction in the scenario of COVID-19 pandemic in patients screened by the telemonitoring

description: ABSTRACT Objective To assess the clinical and epidemiological profile of patients with olfactory dysfunction in the scenario of COVID-19 pandemic. Methods The study selected patients with loss of smell, previously screened by telemonitoring system of the Municipal Health Department of Goiânia (GO), Brazil, who agreed to answer a questionnaire about COVID-19 symptoms and findings of exams. The interviews were conducted by six otolaryngologists, who applied the specific questionnaire, over the phone. Results A total of 13,910 patients underwent telemonitoring, and 627 (4.51%) had olfactory loss complaints. Out of them, 330 were included in the survey. We observed a higher prevalence of altered smell in women (67%), and in patients aged under 50 years (86%). In most cases the manifestations had a sudden onset (70%), and in the first 5 days of illness (80%). The most prevalent associated symptom was a change in taste (89%), and only 2.7% of interviewed patients required hospitalization. Conclusion Anosmia in COVID-19 is more prevalent in females and individuals aged under 50 years. It is a relevant initial symptom predictive of the disease, together with dysgeusia.
DOI: 10.6084/m9.figshare.19923636.v1
title: Olfactory dysfunction in the scenario of COVID-19 pandemic in patients screened by the telemonitoring

description: ABSTRACT Objective To assess the clinical and epidemiological profile of patients with olfactory dysfunction in the scenario of COVID-19 pandemic. Methods The study selected patients with loss of smell, previously screened by telemonitoring system of the Municipal Health Department of Goiânia (GO), Brazil, who agreed to answer a questionnaire about COVID-19 symptoms and findings of exams. The interviews were conducted by six otolaryngologists, who applied the specific questionnaire, over the phone. Results A total of 13,910 patients underwent telemonitoring, and 627 (4.51%) had olfactory loss complaints. Out of them, 330 were included in the survey. We observed a higher prevalence of altered smell in women (67%), and in patients aged under 50 years (86%). In most cases the manifestations had a sudden onset (70%), and in the first 5 days of illness (80%). The most prevalent associated symptom was a change in taste (89%), and only 2.7% of interviewed patients required hospitalization. Conclusion Anosmia in COVID-19 is more prevalent in females and individuals aged under 50 years. It is a relevant initial symptom predictive of the disease, together with dysgeusia.
DOI: 10.6084/m9.figshare.19923637
title: Artificial intelligence forecasting mortality at an intensive care unit and comparison to a logistic regression system

description: ABSTRACT Objective To explore an artificial intelligence approach based on gradient-boosted decision trees for prediction of all-cause mortality at an intensive care unit, comparing its performance to a recent logistic regression system in the literature, and a logistic regression model built on the same platform. Methods A gradient-boosted decision trees model and a logistic regression model were trained and tested with the Medical Information Mart for Intensive Care database. The 1-hour resolution physiological measurements of adult patients, collected during 5 hours in the intensive care unit, consisted of eight routine clinical parameters. The study addressed how the models learn to categorize patients to predict intensive care unit mortality or survival within 12 hours. The performance was evaluated with accuracy statistics and the area under the Receiver Operating Characteristic curve. Results The gradient-boosted trees yielded an area under the Receiver Operating Characteristic curve of 0.89, compared to 0.806 for the logistic regression. The accuracy was 0.814 for the gradient-boosted trees, compared to 0.782 for the logistic regression. The diagnostic odds ratio was 17.823 for the gradient-boosted trees, compared to 9.254 for the logistic regression. The Cohen’s kappa, F-measure, Matthews correlation coefficient, and markedness were higher for the gradient-boosted trees. Conclusion The discriminatory power of the gradient-boosted trees was excellent. The gradient-boosted trees outperformed the logistic regression regarding intensive care unit mortality prediction. The high diagnostic odds ratio and markedness values for the gradient-boosted trees are important in the context of the studied unbalanced dataset.