cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20382323.v1
title: Effect of Dietary Growth Promoter Supplementations on the Serum Biochemistry and Morphometric Characteristics of Tibia Bone in Broiler Chicken

description: ABSTRACT Bone mineralization is considered an essential source of minerals for metabolic needs that provide strength and hardness to the bone tissues and in birds its development can be enhanced by the use of dietary supplements. The present study was executed to evaluate the influence of prebiotic, probiotic and antibiotic on the morphometric aspects of tibia bone in broilers. One-hundred and sixty-one-day-old broiler chick were divided randomly into four groups (n=40) with 4 replicates (n=10 in each replicate). Group-I fed with only corn based basal diet and served as controlled group. Group-II with antibiotic supplement (Zinc bacitracin 0.04%), Group-III with probiotic supplement (lactobacillus 0.1%) & Group-IV with prebiotic supplement (mannan oligosaccharide 0.1%). On the 35th day, two birds were selected randomly from each replicate and slaughtered to record the morphometric parameters of both right and left tibia bones from each bird. The findings showed that the length, weight, thickness of lateral and medial wall, tibiotarsal index of bone and bone ash percentage of supplemented groups have had significant (p&lt;0.05) difference when compared to that of the controlled group. The weight/length index in birds supplemented with prebiotic and probiotic was significantly higher (p&lt;0.05) than in the antibiotic supplemented and control group. Medullary canal diameter of all the supplemented groups was significantly lower (p&lt;0.05) than the control group. No significant (p&gt;0.05) difference of robusticity index and diaphysis diameter was observed among various groups. A significant (p&lt;0.05) low level of Alkaline Phosphatase while higher level of Calcium and Phosphorus was recorded in the supplemented groups compared to that of the control group. In conclusion, the use of prebiotic and probiotic as growth promoter can exhibit some underline mechanisms in the form of enhancement of bone quality, density and characteristics in broiler chicks as compared to common antibiotics.
DOI: 10.25402/fsg.20382225
title: bmm-2022-0071 Table S1

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.25402/fsg.20382225.v1
title: bmm-2022-0071 Table S1

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.25402/fsg.20382222
title: bmm-2022-0071 Supplementary materials

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.25402/fsg.20382222.v1
title: bmm-2022-0071 Supplementary materials

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.6084/m9.figshare.20382325
title: A tour of the museums of northwestern Mexico: reflections on the pattern of colonial power in a local history

description: ABSTRACT This paper aims to analyze how a local history that is built under the pattern of colonial power on the nation's border is vindicated. Through the analysis of the discourses that lie in the main museums of Baja California, Mexico, it is argued that they reproduce a redefined national history according to the understanding of a local history, driven by knowledge that justifies and exalts an evolutionary perspective to define, through socio-cultural classifications, us and others of the territory. It is concluded that local history reproduces and strengthens the idea of value that originates from the dichotomous human / non-human relationship, the central matrix for the modern / colonial / capitalist system.
DOI: 10.6084/m9.figshare.20382325.v1
title: A tour of the museums of northwestern Mexico: reflections on the pattern of colonial power in a local history

description: ABSTRACT This paper aims to analyze how a local history that is built under the pattern of colonial power on the nation's border is vindicated. Through the analysis of the discourses that lie in the main museums of Baja California, Mexico, it is argued that they reproduce a redefined national history according to the understanding of a local history, driven by knowledge that justifies and exalts an evolutionary perspective to define, through socio-cultural classifications, us and others of the territory. It is concluded that local history reproduces and strengthens the idea of value that originates from the dichotomous human / non-human relationship, the central matrix for the modern / colonial / capitalist system.
DOI: 10.25402/fsg.20382231
title: bmm-2022-0071 Figure S1

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.25402/fsg.20382231.v1
title: bmm-2022-0071 Figure S1

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.25402/fsg.20382234
title: bmm-2022-0071 Figure S2

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.25402/fsg.20382234.v1
title: bmm-2022-0071 Figure S2

description: Aims: To combat increases in colorectal cancer (CRC) incidence and mortality, biomarkers among differentially expressed genes (DEGs) have been identified to objectively detect cancer. However, DEGs are numerous, and additional parameters may identify more reliable biomarkers. Here, CRC DEGs were filtered into a prioritized list of biomarkers. Materials & methods: Two independent datasets (COAD-READ [n = 698] and GSE50760 [n = 36]) were input alternatively to the recently published data-driven reference method. Results were filtered based on epithelial–mesenchymal transition enrichment (χ-square statistic: 919.05; p = 2.2e-16) to produce 37 potential CRC biomarkers. Results: All 37 genes reliably classified CRC samples and ETV4, CLDN1 and CA2 together were top-ranked by DDR (accuracy: 89%; F1 score: 0.89). Conclusion: Biological and statistical information were combined to produce a better set of CRC detection biomarkers.
DOI: 10.6084/m9.figshare.20382328
title: Bulb yield and economic viability of onion in response to sulfur fertilization

description: ABSTRACT The cultivation of onion in the Brazilian Northeast region has been gaining prominence due to the favorable edaphoclimatic conditions and the use of technology. However, the increase in production costs, price fluctuations and the suppression of sulfur in fertilizer formulations constitute a risk for the farmers. Thus, the aim of this study was to evaluate the productive and economic aspects of onion production as a response to sulfur fertilization. Two experiments were carried out from June to November 2018 and 2019, at the Rafael Fernandes Experimental Farm, belonging to the Universidade Federal Rural do Semi-árido, in the municipality of Mossoró, Rio Grande do Norte, Brazil, in an Ultisol. The experimental design was randomized complete blocks with 14 treatments and four replicates, corresponding to the combination of two onion cultivars and seven doses of sulfur. The following characteristics were evaluated: sulfur content in the diagnostic leaf, bulb yield, total operating costs, gross revenue, net revenue, rate of return and yield index. Regardless of the cultivar, input costs add up to higher expenses, reaching approximate values of 60.6 and 48.4% of the total operating cost for the Rio das Antas and IPA 11 cultivars, respectively. Rio das Antas was more sulfur efficient, achieving greater bulb yield and net revenue. The 34 kg ha-1 sulfur dose promoted maximum yield and net revenue for Rio das Antas. The application of sulfur did not influence the yield of the IPA 11 cultivar.
DOI: 10.6084/m9.figshare.20382328.v1
title: Bulb yield and economic viability of onion in response to sulfur fertilization

description: ABSTRACT The cultivation of onion in the Brazilian Northeast region has been gaining prominence due to the favorable edaphoclimatic conditions and the use of technology. However, the increase in production costs, price fluctuations and the suppression of sulfur in fertilizer formulations constitute a risk for the farmers. Thus, the aim of this study was to evaluate the productive and economic aspects of onion production as a response to sulfur fertilization. Two experiments were carried out from June to November 2018 and 2019, at the Rafael Fernandes Experimental Farm, belonging to the Universidade Federal Rural do Semi-árido, in the municipality of Mossoró, Rio Grande do Norte, Brazil, in an Ultisol. The experimental design was randomized complete blocks with 14 treatments and four replicates, corresponding to the combination of two onion cultivars and seven doses of sulfur. The following characteristics were evaluated: sulfur content in the diagnostic leaf, bulb yield, total operating costs, gross revenue, net revenue, rate of return and yield index. Regardless of the cultivar, input costs add up to higher expenses, reaching approximate values of 60.6 and 48.4% of the total operating cost for the Rio das Antas and IPA 11 cultivars, respectively. Rio das Antas was more sulfur efficient, achieving greater bulb yield and net revenue. The 34 kg ha-1 sulfur dose promoted maximum yield and net revenue for Rio das Antas. The application of sulfur did not influence the yield of the IPA 11 cultivar.
DOI: 10.6084/m9.figshare.20290778
title: Optimization of glycerol-based medium composition for antifungal metabolites production by Bacillus subtilis

description: Abstract Bacillus species are promising producers of various compounds that have pronounced antimicrobial, antiviral and antitumor activities. Due to its GRAS status, Bacillus subtilis represents an excellent candidate for the usage in plant pathogens biocontrol. In this research, evaluation of antifungal metabolites biosynthesis by Bacillus subtilis ATCC 6633 and optimization of glycerol-based medium composition, using response surface methodology, for the production of compounds effective against Neurospora crassa were investigated. The results of disc-diffusion method indicate that applied Bacillus strain produces compounds with antifungal activity against tested fungus. In order to find optimal cultivation medium composition, the experiments were carried out in accordance with Box-Behnken design, and optimization was performed using the concept of desirability function combined with previously defined mathematical equation, which describes examined bioprocess. The optimization model predicts that maximum inhibition zone diameter against Neurospora crassa of 32.24 mm is achieved when initial content of glycerol, NaNO2 and K2HPO4 were 49.68 g/L, 2.90 g/L and 6.49 g/L, respectively. Additionally, the second optimization set was made to minimize the consumption of medium components and costs of medium preparation. The obtained results are the basis for further research aimed to develop medium appropriate for economically justified production of bioactive compounds at industrial scale.
DOI: 10.6084/m9.figshare.20290778.v1
title: Optimization of glycerol-based medium composition for antifungal metabolites production by Bacillus subtilis

description: Abstract Bacillus species are promising producers of various compounds that have pronounced antimicrobial, antiviral and antitumor activities. Due to its GRAS status, Bacillus subtilis represents an excellent candidate for the usage in plant pathogens biocontrol. In this research, evaluation of antifungal metabolites biosynthesis by Bacillus subtilis ATCC 6633 and optimization of glycerol-based medium composition, using response surface methodology, for the production of compounds effective against Neurospora crassa were investigated. The results of disc-diffusion method indicate that applied Bacillus strain produces compounds with antifungal activity against tested fungus. In order to find optimal cultivation medium composition, the experiments were carried out in accordance with Box-Behnken design, and optimization was performed using the concept of desirability function combined with previously defined mathematical equation, which describes examined bioprocess. The optimization model predicts that maximum inhibition zone diameter against Neurospora crassa of 32.24 mm is achieved when initial content of glycerol, NaNO2 and K2HPO4 were 49.68 g/L, 2.90 g/L and 6.49 g/L, respectively. Additionally, the second optimization set was made to minimize the consumption of medium components and costs of medium preparation. The obtained results are the basis for further research aimed to develop medium appropriate for economically justified production of bioactive compounds at industrial scale.
DOI: 10.6084/m9.figshare.20382329.v1
title: THORACOLUMBAR FUSION IN THE UNIFIED HEALTH SYSTEM: PRE-COVID-19 TEMPORAL

description: ABSTRACT Objective: To evaluate the temporal trends of thoracolumbar fusion procedures performed by the United Health System in Brazil from 2009 to 2019. Methods: This was an observational ecological study based on data collected from the information systems under the aegis of DATASUS, especially the Hospital Information System, which manages the Hospital Admission Authorizations (Autorizações de Internação Hospitalar - AIHs). All patients who had undergone the procedures of interest, that is, elective and emergency short and long thoracolumbar arthrodeses, were included. The temporal trends of the procedures performed in Brazil and in its five regions were calculated using polynomial regression. Results: The temporal trend of elective thoracolumbar arthrodesis decreased, while that of emergency arthrodesis increased, with the peak in 2015, followed by a marked decline. Short fusions were more frequent in both elective and emergency modalities, and the South and Central-West Regions had the highest indices of procedures per million inhabitants during the entire 2009 to 2019 period. Conclusions: The temporal trends of thoracolumbar fusions performed by SUS have decreased over the last decade, a phenomenon which may be explained by the growing criticism of indications of the procedure in the current literature. Level of evidence III; Retrospective Comparative Study.
DOI: 10.6084/m9.figshare.20382329
title: THORACOLUMBAR FUSION IN THE UNIFIED HEALTH SYSTEM: PRE-COVID-19 TEMPORAL

description: ABSTRACT Objective: To evaluate the temporal trends of thoracolumbar fusion procedures performed by the United Health System in Brazil from 2009 to 2019. Methods: This was an observational ecological study based on data collected from the information systems under the aegis of DATASUS, especially the Hospital Information System, which manages the Hospital Admission Authorizations (Autorizações de Internação Hospitalar - AIHs). All patients who had undergone the procedures of interest, that is, elective and emergency short and long thoracolumbar arthrodeses, were included. The temporal trends of the procedures performed in Brazil and in its five regions were calculated using polynomial regression. Results: The temporal trend of elective thoracolumbar arthrodesis decreased, while that of emergency arthrodesis increased, with the peak in 2015, followed by a marked decline. Short fusions were more frequent in both elective and emergency modalities, and the South and Central-West Regions had the highest indices of procedures per million inhabitants during the entire 2009 to 2019 period. Conclusions: The temporal trends of thoracolumbar fusions performed by SUS have decreased over the last decade, a phenomenon which may be explained by the growing criticism of indications of the procedure in the current literature. Level of evidence III; Retrospective Comparative Study.
DOI: 10.6084/m9.figshare.20290807
title: Psychoactive drugs in the Brazilian public health system: Use profile and associated factors

description: Abstract The purpose of this study is to estimate the prevalence of and characterize the use of psychoactive drugs among drug users in a Brazilian municipality, relating the findings to factors associated with the consumption of these substances. Through a cross-sectional design, 1,355 drug users from the public health systems community pharmacies were interviewed. Sociodemographic and health-related data were collected, as well as any other prescribed drugs. The prevalence of psychoactive drug use within the last month was 31.0%, with antidepressants and benzodiazepines being the most prescribed (53.5% and 24.6% respectively). Most psychoactive drug users were female (81.9%), lived with a partner (52.6%), had private health insurance (69.2%) and a monthly per-capita income up to one minimum wage (54.0%). The adjusted Odds Ratio (OR) confirmed the following factors to be positively associated with the use of psychoactive drugs: female gender (OR=2.06; 95% CI 1.44; 2.95), age ≥60 years old (OR=1.77; 95% CI 1.26; 2.48), follow-up with a psychologist (OR=4.12; 95% CI 1.84; 5.25), absence of regular physical activity (OR=1.59; 95% CI 1.13; 2.23), and smokers (OR=1.94; 95% CI 1.26; 2.97). Approximately one out of three individuals used at least one psychoactive drug. Health managers should focus the planning and actions aimed at their rational use for these groups, leading to increased overall treatment success.