cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21835495
title: Saline pisciculture effluent as an alternative for irrigation of Croton blanchetianus (Euphorbiaceae)

description: ABSTRACT The use of saline effluents from fish farming in agricultural activities has been increasing, especially in semiarid regions. This study was to evaluate the use of saline effluents from fish farming for the irrigation of Croton blanchetianus and to analyze the physiological and biochemical responses. After the cuttings were planted, irrigation with the effluent began. Treatments included four salinity levels (control, 1.5, 2.5, 3.5 dS m-1). The control treatment was the supply water (0.56 dS m-1). The evaluated variables were growth, relative water content, dry biomass, and levels of proteins, proline, hydrogen peroxide, malondialdehyde, and photosynthetic pigments. Physiological and biochemical adjustments ensured the maintenance of relative water content and osmotic adjustment under saline conditions without increasing lipid peroxidation. The salinity levels did not affect C. blanchetianus, indicating the lack of saline stress. The fish farm effluents are rich in organic matter, from food, and excrement, which was beneficial for the development of C. blanchetianus. The reuse of saline effluents from fish farming for the irrigation of C. blanchetianus can be a viable environmental alternative, avoiding direct disposal into the environment.
DOI: 10.6084/m9.figshare.21835495.v1
title: Saline pisciculture effluent as an alternative for irrigation of Croton blanchetianus (Euphorbiaceae)

description: ABSTRACT The use of saline effluents from fish farming in agricultural activities has been increasing, especially in semiarid regions. This study was to evaluate the use of saline effluents from fish farming for the irrigation of Croton blanchetianus and to analyze the physiological and biochemical responses. After the cuttings were planted, irrigation with the effluent began. Treatments included four salinity levels (control, 1.5, 2.5, 3.5 dS m-1). The control treatment was the supply water (0.56 dS m-1). The evaluated variables were growth, relative water content, dry biomass, and levels of proteins, proline, hydrogen peroxide, malondialdehyde, and photosynthetic pigments. Physiological and biochemical adjustments ensured the maintenance of relative water content and osmotic adjustment under saline conditions without increasing lipid peroxidation. The salinity levels did not affect C. blanchetianus, indicating the lack of saline stress. The fish farm effluents are rich in organic matter, from food, and excrement, which was beneficial for the development of C. blanchetianus. The reuse of saline effluents from fish farming for the irrigation of C. blanchetianus can be a viable environmental alternative, avoiding direct disposal into the environment.
DOI: 10.6084/m9.figshare.21835497
title: Computational analysis and in vitro investigation on Citrus flavonoids for inflammatory, diabetic and AGEs targets

description: Abstract Flavonoids are a diverse class of polyphenolic substances largely found in plants including citrus peels and are reported to posess a variety of biological activities. We investigated important flavonoids apigenin, hesperidin, narigin, quercetin and tangeritine against diabetes and associated conditions. In current project drug likeness, ADMET analysis, molecular docking and in vitro assays were performed. The apigenin, quercetin and tanagretin exhibited compliance with Lipinski’s rule of five. The molecular docking analysis showed best fit in transcriptional regulator 3TOP and 1IK3 in all tested compounds. During antioxidant assays, all flavonoids presented excellent activities. In the α-glucosidase assay, quercetin showed highest inhibition (76% at final concentration of 52 µg/ml) followed by tangeritin (73% at final concentration of 52 µg/ml). In case of 15-Lox assay, highest inhibition was seen in case of quercetin (75%) followed by apigenin (53%). In the AGEs assay, the quercetin showed 47% inhbition of protein cross link formation preceeded by the tenegretin exhited 37% inhibition. It was therefore concluded that tested flavonoids have significant activities in both in silico and in vitro models that is mainly due to differences in structural features and polar surface area.
DOI: 10.6084/m9.figshare.21835497.v1
title: Computational analysis and in vitro investigation on Citrus flavonoids for inflammatory, diabetic and AGEs targets

description: Abstract Flavonoids are a diverse class of polyphenolic substances largely found in plants including citrus peels and are reported to posess a variety of biological activities. We investigated important flavonoids apigenin, hesperidin, narigin, quercetin and tangeritine against diabetes and associated conditions. In current project drug likeness, ADMET analysis, molecular docking and in vitro assays were performed. The apigenin, quercetin and tanagretin exhibited compliance with Lipinski’s rule of five. The molecular docking analysis showed best fit in transcriptional regulator 3TOP and 1IK3 in all tested compounds. During antioxidant assays, all flavonoids presented excellent activities. In the α-glucosidase assay, quercetin showed highest inhibition (76% at final concentration of 52 µg/ml) followed by tangeritin (73% at final concentration of 52 µg/ml). In case of 15-Lox assay, highest inhibition was seen in case of quercetin (75%) followed by apigenin (53%). In the AGEs assay, the quercetin showed 47% inhbition of protein cross link formation preceeded by the tenegretin exhited 37% inhibition. It was therefore concluded that tested flavonoids have significant activities in both in silico and in vitro models that is mainly due to differences in structural features and polar surface area.
DOI: 10.6084/m9.figshare.21755600
title: Changes in the Brazilian rural sector during the 2010s

description: Abstract The 2010s saw an increase in the share of non-agricultural families living in Brazil´s rural areas and a decrease in the share of agricultural and pluriactive families. In order to better understand this new phenomena, this paper first uses secondary dataset to illustrate the issue, followed by a multinomial model and dataset from the Continuous Pnads in order to evaluate the importance of individual attributes, family features, the family workforce´s occupation type and the regional location considering the probability of a rural family to be non-agricultural or pluriactive in relation to be an agricultural family. Statistical results allow us to conclude that any rural family living outside of the Central-West are more likely to be a non-agricultural or pluriactive family than an agricultural family. As the rural family has a retired person among its members, has a greater number of members and its head is either black, indigenous or a person of color the probability of being a non-agricultural family is greater in relation to an agricultural family. The probability that a rural family is pluriactive, in relation to agricultural, increases, since it produces for self-consumption, is a beneficiary of the government-allowance-program, and has a greater number of dependents.
DOI: 10.6084/m9.figshare.21755600.v1
title: Changes in the Brazilian rural sector during the 2010s

description: Abstract The 2010s saw an increase in the share of non-agricultural families living in Brazil´s rural areas and a decrease in the share of agricultural and pluriactive families. In order to better understand this new phenomena, this paper first uses secondary dataset to illustrate the issue, followed by a multinomial model and dataset from the Continuous Pnads in order to evaluate the importance of individual attributes, family features, the family workforce´s occupation type and the regional location considering the probability of a rural family to be non-agricultural or pluriactive in relation to be an agricultural family. Statistical results allow us to conclude that any rural family living outside of the Central-West are more likely to be a non-agricultural or pluriactive family than an agricultural family. As the rural family has a retired person among its members, has a greater number of members and its head is either black, indigenous or a person of color the probability of being a non-agricultural family is greater in relation to an agricultural family. The probability that a rural family is pluriactive, in relation to agricultural, increases, since it produces for self-consumption, is a beneficiary of the government-allowance-program, and has a greater number of dependents.
DOI: 10.6084/m9.figshare.21835498
title: Applications of polysaccharides in topical and transdermal drug delivery: A recent update of literature

description: Abstract The main aim of transdermal drug delivery (TDD) is to deliver a specific dose of drug across the skin and to reach systemic circulation at a controlled rate. On the other hand skin is the target for topical drug delivery. Mentioned drug delivery systems (DDS) have numerous advantages compared to oral and parenteral routes. Avoidance of first-pass metabolism, prevent drug degradation due to harsh environment of the stomach, allow controlled drug delivery, provide patient compliance, and pain-free administration are a few of them. To achieve all of them, a DDS with suitable polymer is the primary requisite. Based on the recent trends, natural polymers have been more popular in comparison to synthetic polymers because the former possesses favourable properties including nontoxic, biodegradable, biocompatible, low cost, sustainable and renewable resources. In this context polysaccharides, composed of chains of monosaccharides bound together by glycosidic bonds, have been successfully employed to augment drug delivery into and across the skin with various formulations such as gel, membrane, patches, nanoparticles, nanofibres, nanocomposite, and microneedles. In this chapter, various polysaccharides such as cellulose, chitosan, and their semisynthetic derivatives, alginate, pectin, carrageenan etc, were discussed with their diverse topical and TDD applications. In addition, various formulations based on polysaccharides and limitations of polysaccharides were also briefly discussed.
DOI: 10.6084/m9.figshare.21835498.v1
title: Applications of polysaccharides in topical and transdermal drug delivery: A recent update of literature

description: Abstract The main aim of transdermal drug delivery (TDD) is to deliver a specific dose of drug across the skin and to reach systemic circulation at a controlled rate. On the other hand skin is the target for topical drug delivery. Mentioned drug delivery systems (DDS) have numerous advantages compared to oral and parenteral routes. Avoidance of first-pass metabolism, prevent drug degradation due to harsh environment of the stomach, allow controlled drug delivery, provide patient compliance, and pain-free administration are a few of them. To achieve all of them, a DDS with suitable polymer is the primary requisite. Based on the recent trends, natural polymers have been more popular in comparison to synthetic polymers because the former possesses favourable properties including nontoxic, biodegradable, biocompatible, low cost, sustainable and renewable resources. In this context polysaccharides, composed of chains of monosaccharides bound together by glycosidic bonds, have been successfully employed to augment drug delivery into and across the skin with various formulations such as gel, membrane, patches, nanoparticles, nanofibres, nanocomposite, and microneedles. In this chapter, various polysaccharides such as cellulose, chitosan, and their semisynthetic derivatives, alginate, pectin, carrageenan etc, were discussed with their diverse topical and TDD applications. In addition, various formulations based on polysaccharides and limitations of polysaccharides were also briefly discussed.
DOI: 10.6084/m9.figshare.21835503
title: Estimation of some vital trace elements in patients with acute pancreatitis: A case-control study

description: Abstract Trace elements have an important influence on the living system and play a major role in a variety of processes necessary for life. This case study was conducted as an attempt to expand our knowledge of the relationship between trace elements and their effect on acute pancreatitis. Sixty-five patients diagnosed with acute pancreatitis with mean age 43.6 years, along with sixty-five healthy volunteers with a mean age 45.7 years, were included in this study. The obtained results indicated a significant increase in the Cu, Ni and Cr levels, and a significant decrease in the Zn, Mg and Fe levels for acute pancreatitis patients compared with the control group (p &lt;0.001). In addition, a remarkable increase in the Cu/Zn ratio was observed in patients. The current work provides important evidence of correlation between changes in copper and zinc levels and the risk of acute pancreatitis. Also, an increased Cu/Zn ratio may be a useful indication for the diagnosis and monitoring of acute pancreatitis. Moreover, the current study concluded that there is a possible relationship of Mg, Fe, Ni and Cr with acute pancreatitis. Thus, it can be suggested that these elements are reliable to provide indications for warning of the risk of acute pancreatitis.
DOI: 10.6084/m9.figshare.21835503.v1
title: Estimation of some vital trace elements in patients with acute pancreatitis: A case-control study

description: Abstract Trace elements have an important influence on the living system and play a major role in a variety of processes necessary for life. This case study was conducted as an attempt to expand our knowledge of the relationship between trace elements and their effect on acute pancreatitis. Sixty-five patients diagnosed with acute pancreatitis with mean age 43.6 years, along with sixty-five healthy volunteers with a mean age 45.7 years, were included in this study. The obtained results indicated a significant increase in the Cu, Ni and Cr levels, and a significant decrease in the Zn, Mg and Fe levels for acute pancreatitis patients compared with the control group (p &lt;0.001). In addition, a remarkable increase in the Cu/Zn ratio was observed in patients. The current work provides important evidence of correlation between changes in copper and zinc levels and the risk of acute pancreatitis. Also, an increased Cu/Zn ratio may be a useful indication for the diagnosis and monitoring of acute pancreatitis. Moreover, the current study concluded that there is a possible relationship of Mg, Fe, Ni and Cr with acute pancreatitis. Thus, it can be suggested that these elements are reliable to provide indications for warning of the risk of acute pancreatitis.
DOI: 10.6084/m9.figshare.21835501
title: Characteristics associated with dietary patterns in Brazilian children under two years of age

description: ABSTRACT OBJECTIVE To analyze the dietary patterns of Brazilian children under two years of age and assess their association with sociodemographic characteristics and health service use. METHODS This is a cross-sectional study with data from the 2013 National Health Survey (PNS). Patterns were found for two age groups by principal component analysis and their correlation with characteristics of interest was tested by linear regression models. RESULTS We found two dietary patterns for our groups. The first consisted of the consumption of fresh or minimally processed foods and the second, of ultra-processed foods. The greater adherence of children between six and 11 months to the first pattern was associated with higher per capita family income and urban residences in the most developed regions of Brazil. At 12 months or more, adherence related to white race/color, higher per capita family incomes, residence in more developed regions, and visits to private childcare. Adherence to the second pattern among children under one year of age was inversely associated with Yellow or Indigenous race/color, residence in the Brazilian Northeast, and childcare in specialized public or private services. At 12 months or more, greater adherence was directly associated with Black or Brown children who resided in more developed regions, and inversely associated with those living in the Brazilian Northeast. CONCLUSION We found two opposite dietary patterns in Brazilian children under two years of age and that several social determinants modify their chance of adhering to these patterns.
DOI: 10.6084/m9.figshare.21835501.v1
title: Characteristics associated with dietary patterns in Brazilian children under two years of age

description: ABSTRACT OBJECTIVE To analyze the dietary patterns of Brazilian children under two years of age and assess their association with sociodemographic characteristics and health service use. METHODS This is a cross-sectional study with data from the 2013 National Health Survey (PNS). Patterns were found for two age groups by principal component analysis and their correlation with characteristics of interest was tested by linear regression models. RESULTS We found two dietary patterns for our groups. The first consisted of the consumption of fresh or minimally processed foods and the second, of ultra-processed foods. The greater adherence of children between six and 11 months to the first pattern was associated with higher per capita family income and urban residences in the most developed regions of Brazil. At 12 months or more, adherence related to white race/color, higher per capita family incomes, residence in more developed regions, and visits to private childcare. Adherence to the second pattern among children under one year of age was inversely associated with Yellow or Indigenous race/color, residence in the Brazilian Northeast, and childcare in specialized public or private services. At 12 months or more, greater adherence was directly associated with Black or Brown children who resided in more developed regions, and inversely associated with those living in the Brazilian Northeast. CONCLUSION We found two opposite dietary patterns in Brazilian children under two years of age and that several social determinants modify their chance of adhering to these patterns.
DOI: 10.6084/m9.figshare.21835506
title: Adaptation of practical classes of clinical subjects in the COVID-19 era

description: Abstract Pharmaceutical Care is a subject within the Pharmacy Degree that is taught using theoretical and practical classes. When COVID-19 appeared, Faculty of Pharmacy had to change its way of teaching and learning to online classes. Our aim is to assess the impact of COVID-19 situation on practical classes in Pharmaceutical Care. A prospective study was performed by undergraduate students from Pharmaceutical Care subject. Students attended to 2-day practical classes and were assessed through an evaluative workbook. Undergraduate students (n=390) obtained a score of 8.4±0.8 in practical classes, being higher in face-to-face sessions than online sessions, but not significant differences among both methodologies. The higher score was for the session of minor ailment services (9.3±1.3) and the lower for Personalized Medication Dosage (7.0±1.6) and similar in both scenarios. 59% of students obtained more than 8 score in the global punctuation, being higher in in-face-to-face practical classes. This study showed that learning in health care can be guided and evaluated through an online method. Adapt to new technologies, prevent vulnerable students from being left behind, as well as working on cross-cutting skills at a distance, are some of the challenges of higher education in times of COVID-19.
DOI: 10.6084/m9.figshare.21835506.v1
title: Adaptation of practical classes of clinical subjects in the COVID-19 era

description: Abstract Pharmaceutical Care is a subject within the Pharmacy Degree that is taught using theoretical and practical classes. When COVID-19 appeared, Faculty of Pharmacy had to change its way of teaching and learning to online classes. Our aim is to assess the impact of COVID-19 situation on practical classes in Pharmaceutical Care. A prospective study was performed by undergraduate students from Pharmaceutical Care subject. Students attended to 2-day practical classes and were assessed through an evaluative workbook. Undergraduate students (n=390) obtained a score of 8.4±0.8 in practical classes, being higher in face-to-face sessions than online sessions, but not significant differences among both methodologies. The higher score was for the session of minor ailment services (9.3±1.3) and the lower for Personalized Medication Dosage (7.0±1.6) and similar in both scenarios. 59% of students obtained more than 8 score in the global punctuation, being higher in in-face-to-face practical classes. This study showed that learning in health care can be guided and evaluated through an online method. Adapt to new technologies, prevent vulnerable students from being left behind, as well as working on cross-cutting skills at a distance, are some of the challenges of higher education in times of COVID-19.
DOI: 10.6084/m9.figshare.21835507
title: Development and Evaluation of Vaginal Suppository Containing Althaea officinalis L. Polysaccharide Extract

description: Abstract Intrauterine adhesions cause several gynecological problems. Althaea officinalis L. roots known as marshmallows contain polysaccharides (M.P.) which possess anti-inflammatory and anti-ulcerogenic activities also can form a bio-adhesive layer on damaged epithelial membranes prompting healing processes. Vaginal formulations of herbal origin are commonly applied to relieve cervico-uterine inflammation. Herein, we aim to develop and evaluate vaginal suppositories containing polysaccharides isolated from the A. officinalis root. Six formulations (four P.E.G.-based and two lipid-based suppositories containing 25% and 50% M.P.) met standard requirements, which were then subjected to qualitative and quantitative evaluation. All suppositories exhibited acceptable weights, hardness, content uniformity, melting point, and disintegration time, which fall within the acceptable recommended limits. Higher concentrations of M.P. in PEG-bases moderately increased the hardness (p&lt;0.05). PEG-formulations showed content uniformity&gt;90% of the average content while it was 75-83% for suppocire formulations. All formulations disintegrated in&lt;30minutes. In-vitro release test revealed that M.P. release from 25%-MP formulations was higher than that of 50%-M.P. suppositories. Overall, results revealed the feasibility of preparing P.E.G.-or lipid-based suppositories containing M.P., which met the B.P. quality requirement.
DOI: 10.6084/m9.figshare.21835507.v1
title: Development and Evaluation of Vaginal Suppository Containing Althaea officinalis L. Polysaccharide Extract

description: Abstract Intrauterine adhesions cause several gynecological problems. Althaea officinalis L. roots known as marshmallows contain polysaccharides (M.P.) which possess anti-inflammatory and anti-ulcerogenic activities also can form a bio-adhesive layer on damaged epithelial membranes prompting healing processes. Vaginal formulations of herbal origin are commonly applied to relieve cervico-uterine inflammation. Herein, we aim to develop and evaluate vaginal suppositories containing polysaccharides isolated from the A. officinalis root. Six formulations (four P.E.G.-based and two lipid-based suppositories containing 25% and 50% M.P.) met standard requirements, which were then subjected to qualitative and quantitative evaluation. All suppositories exhibited acceptable weights, hardness, content uniformity, melting point, and disintegration time, which fall within the acceptable recommended limits. Higher concentrations of M.P. in PEG-bases moderately increased the hardness (p&lt;0.05). PEG-formulations showed content uniformity&gt;90% of the average content while it was 75-83% for suppocire formulations. All formulations disintegrated in&lt;30minutes. In-vitro release test revealed that M.P. release from 25%-MP formulations was higher than that of 50%-M.P. suppositories. Overall, results revealed the feasibility of preparing P.E.G.-or lipid-based suppositories containing M.P., which met the B.P. quality requirement.