cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21516350.v1
title: Association of cigarette and water-pipe smoking with increased visceral adiposity, glycemic intolerance and hematological derangement in Iraqi healthy smokers

description: Abstract The present study aims to investigate the impacts of cigarette smoking (CS) and water-pipe smoking (WPS) on the visceral adiposity index (VAI), hematological characteristics, and glycemic tolerance in Iraqi healthy smokers. A total of 528 healthy males from different locations of Baghdad city were allocated to three groups; nonsmokers (176), cigarette smokers (178), and WP smokers (174). Baseline characteristics, anthropometric and hematological markers and were reported. Glycemic control was evaluated using the glucose tolerance test. The evidence of elevated VAI, disrupted hematological markers, and impaired glucose tolerance was significantly (P&lt;0.001) different compared with non-smokers and related to the duration of smoking. The impacts of WPS seem to be significantly greater than CS in certain parameters (hemoglobin, hematocrit, methemoglobin, and 2-hour glucose tolerance values). In conclusion, CS and WPS negatively impacted body fat distribution, glucose tolerance, and hematological markers. There is a positive association between the rate of smoking and obesity, glycemic intolerance in both groups.
DOI: 10.6084/m9.figshare.21516351
title: UNDERSTANDING AND TRYING TO RECONCILE THE CLIMATE AND THE DIGITAL TRANSITIONS

description: This article focuses on the two main transitions in the current context: the climate and environmental transition and the digital one (digitization of the economy). It emphasizes that thinking and planning for the future is impossible without combining and integrating them. This is because, since the reflections on these transitions are still dispersed most of the time, they cannot show the full meaning of the changes, nor the specific impacts, such as those related to the world of work. Thus, from a more holistic point of view, we seek to analyze the two meta-changes, considering their possible articulations and hierarchies, the consensus and dissent between them, as well as the role of the different social actors in conducting these transitions.
DOI: 10.6084/m9.figshare.21516351.v1
title: UNDERSTANDING AND TRYING TO RECONCILE THE CLIMATE AND THE DIGITAL TRANSITIONS

description: This article focuses on the two main transitions in the current context: the climate and environmental transition and the digital one (digitization of the economy). It emphasizes that thinking and planning for the future is impossible without combining and integrating them. This is because, since the reflections on these transitions are still dispersed most of the time, they cannot show the full meaning of the changes, nor the specific impacts, such as those related to the world of work. Thus, from a more holistic point of view, we seek to analyze the two meta-changes, considering their possible articulations and hierarchies, the consensus and dissent between them, as well as the role of the different social actors in conducting these transitions.
DOI: 10.6084/m9.figshare.21516357
title: Agronomic optimal plant density for corn in subtropical environments

description: Abstract The objective of this work was to determine the agronomic optimal plant density (AOPD) for corn (Zea mays) in environments with a high, medium, and low grain yield, as well as to define which yield component is the most sensitive to variations in plant density. On-farm experiments were conducted in the municipalities of Júlio de Castilhos, in the 2018/2019 growing season, and of Entre-Ijuís, Jóia, Agudo, and Júlio de Castilhos, in the 2019/2020 growing season, in the state of Rio Grande do Sul, Brazil. The production environments were classified as having a low (&lt; 10 Mg ha-1), medium (from 10 to 16 Mg ha-1), and high (&gt; 16 Mg ha-1) grain yield. Júlio de Castilhos was identified as a site of high yield; Jóia and Entre-Ijuís, as of medium yield; and Agudo, as of low yield. The AOPDs ranged from 60,000 to 140,000 plants per hectare in the different production environments. The AOPD was of 110,300 to 116,200 plants per hectare for the high-yield environment, 101,000 plants per hectare for the medium-yield environment, and 60,000 plants per hectare for the low-yield environment. The number of grains per row is the yield component that is the most sensitive to variations in plant density in all production environments.
DOI: 10.6084/m9.figshare.21516357.v1
title: Agronomic optimal plant density for corn in subtropical environments

description: Abstract The objective of this work was to determine the agronomic optimal plant density (AOPD) for corn (Zea mays) in environments with a high, medium, and low grain yield, as well as to define which yield component is the most sensitive to variations in plant density. On-farm experiments were conducted in the municipalities of Júlio de Castilhos, in the 2018/2019 growing season, and of Entre-Ijuís, Jóia, Agudo, and Júlio de Castilhos, in the 2019/2020 growing season, in the state of Rio Grande do Sul, Brazil. The production environments were classified as having a low (&lt; 10 Mg ha-1), medium (from 10 to 16 Mg ha-1), and high (&gt; 16 Mg ha-1) grain yield. Júlio de Castilhos was identified as a site of high yield; Jóia and Entre-Ijuís, as of medium yield; and Agudo, as of low yield. The AOPDs ranged from 60,000 to 140,000 plants per hectare in the different production environments. The AOPD was of 110,300 to 116,200 plants per hectare for the high-yield environment, 101,000 plants per hectare for the medium-yield environment, and 60,000 plants per hectare for the low-yield environment. The number of grains per row is the yield component that is the most sensitive to variations in plant density in all production environments.
DOI: 10.6084/m9.figshare.21516324
title: Dataset.docx

description: Interview and survey data
DOI: 10.6084/m9.figshare.21516324.v1
title: Dataset.docx

description: Interview and survey data
DOI: 10.6084/m9.figshare.21516359
title: Association of PSORS1C3, CARD14 and TLR4 genotypes and haplotypes with psoriasis susceptibility

description: Abstract Psoriasis is a common chronic, immune-mediated inflammatory disease of the skin. PSORS1C3 is a non-protein coding gene, of which the RNA transcript is found in psoriatic patients. CARD14 is mainly expressed in epidermal keratinocytes. TLR4 is a transmembrane protein to recognize microbial antigens. Our study aimed to assess the relationship among PSORS1C3, CARD14 and TLR4 polymorphisms, inflammatory expression and psoriasis susceptibility. To the end, 71 patients with psoriasis and 46 healthy individuals with the well-characterized clinical profiles were enrolled. Gene polymorphisms were determined by Sanger DNA sequencing and secretion of cytokines by ELISA. As a result, genetic analysis of PSORS1C3 gene identified nine SNPs and three haplotype blocks. Sequencing of the CARD14 gene determined eight SNPs and one haplotype block. Sequencing of TLR4 gene identified nine SNPs, in which a SNP rs1018673641 was found to exert deleterious effect. The linkage disequilibrium analysis showed that seven variants in PSORS1C3 gene and three SNPs in CARD14 gene were in tightly linked. More importantly, a significant association between IL-6 level and rs1018673641 AT genotype in TLR4 gene was detected in psoriatic patients. In conclusion, the PSORS1C3, CARD14 and TLR4 polymorphisms and haplotypes may be correlated with risk of suffering psoriasis and the IL-6-mediated chronic inflammation in psoriasis could be partially regulated by the TLR4 functional variant.
DOI: 10.6084/m9.figshare.21516359.v1
title: Association of PSORS1C3, CARD14 and TLR4 genotypes and haplotypes with psoriasis susceptibility

description: Abstract Psoriasis is a common chronic, immune-mediated inflammatory disease of the skin. PSORS1C3 is a non-protein coding gene, of which the RNA transcript is found in psoriatic patients. CARD14 is mainly expressed in epidermal keratinocytes. TLR4 is a transmembrane protein to recognize microbial antigens. Our study aimed to assess the relationship among PSORS1C3, CARD14 and TLR4 polymorphisms, inflammatory expression and psoriasis susceptibility. To the end, 71 patients with psoriasis and 46 healthy individuals with the well-characterized clinical profiles were enrolled. Gene polymorphisms were determined by Sanger DNA sequencing and secretion of cytokines by ELISA. As a result, genetic analysis of PSORS1C3 gene identified nine SNPs and three haplotype blocks. Sequencing of the CARD14 gene determined eight SNPs and one haplotype block. Sequencing of TLR4 gene identified nine SNPs, in which a SNP rs1018673641 was found to exert deleterious effect. The linkage disequilibrium analysis showed that seven variants in PSORS1C3 gene and three SNPs in CARD14 gene were in tightly linked. More importantly, a significant association between IL-6 level and rs1018673641 AT genotype in TLR4 gene was detected in psoriatic patients. In conclusion, the PSORS1C3, CARD14 and TLR4 polymorphisms and haplotypes may be correlated with risk of suffering psoriasis and the IL-6-mediated chronic inflammation in psoriasis could be partially regulated by the TLR4 functional variant.
DOI: 10.6073/pasta/820ecd2cba2f5ce3a2cc4968c52bf6a3
title: Jornada Basin LTER Cross-scale Interactions Study (CSIS) Block 9 meteorological station: 30-minute soil volumetric water content data: 2013 - ongoing

description: 30-minute Soil Moisture data at 10 cm at CSIS Block-9. Collection of soil volumetric water content data at Jornada LTER Cross-scale Interactions Study (CSIS) blocks, New Mexico, supports the environmental monitoring objectives of the Jornada LTER monitoring program that look at plant-soil water dynamics. Soil volumetric water content is measured at 10 cm depth at 3 locations at each of the 4 plots per block. The locations in each plot are under bare soil, under perennial grass, and under shrub. Volumetric water content, bulk electrical conductivity, soil temperature, and bulk dielectric permittivity are recorded every 30 minutes at an automated meteorological station installed at Jornada LTER CSIS Block-9 site. This is an ONGOING dataset.
DOI: 10.6084/m9.figshare.21516360
title: Validity of the Psychological Well-Being Scale with Morbid Female Obesity

description: Abstract Psychological well-being is an important indicator of psychological adjustment. Obesity is considered a progressive disease that results in serious public health problems. This investigation sought validity evidence for the Psychological Well-Being Scale in 293 morbidly obese Brazilian women, aged between 18 and 61 years, who were awaiting bariatric surgery. The scores were submitted to Confirmatory Factor Analysis and several theoretical models were tested. According to the results, an oblique six-dimensional structure presented a good fit to the empirical data. Acceptable indices of internal consistency for the measurement factors were also obtained. The scale may contribute to the development of programs aimed at improving the psychological well-being of people with morbid obesity, before and after bariatric surgery.
DOI: 10.6084/m9.figshare.21516360.v1
title: Validity of the Psychological Well-Being Scale with Morbid Female Obesity

description: Abstract Psychological well-being is an important indicator of psychological adjustment. Obesity is considered a progressive disease that results in serious public health problems. This investigation sought validity evidence for the Psychological Well-Being Scale in 293 morbidly obese Brazilian women, aged between 18 and 61 years, who were awaiting bariatric surgery. The scores were submitted to Confirmatory Factor Analysis and several theoretical models were tested. According to the results, an oblique six-dimensional structure presented a good fit to the empirical data. Acceptable indices of internal consistency for the measurement factors were also obtained. The scale may contribute to the development of programs aimed at improving the psychological well-being of people with morbid obesity, before and after bariatric surgery.
DOI: 10.6084/m9.figshare.21516365
title: Functional independence analysis in persons with spinal cord injury

description: Abstract Introduction Spinal cord injury (SCI) radically changes a person’s life because of alterations in body dynamics, leading to disabilities and reduced functionality. Objective To analyze the functional independence of individuals with spinal cord injury and compare the groups. Methods Individuals with SCI were interviewed about their functional independence using the Brazilian version of the Spinal Cord Independence Measure - Self-Reported Version (brSCIM-SR) and later their respective domains and subdomains were compared between diagnostic groups, time since injury and sex. Results The sample consisted of fifty individuals aged 40.92 ± 13.93 years, predominantly men and diagnosed with paraplegia. In most brSCIM-SR domains, all respondents achieved good independence in self-care, respiration and sphincter management, and in the total brSCIM-SR, except for mobility. In paraplegia, chronic SCIs and both sexes achieved excellent independence in most subdomains and in the total. Significantly low values were found for tetraplegia and recent SCI in the self-care subdomain. In most subdomains, tetraplegia reached significantly lower values. In the subdomains of respiration and sphincter management, the participants were independent in the breathing function, but in tetraplegia, they showed significant dependence on transfer to the toilet. In terms of mobility, there was great dependence on the items going up and down stairs and transfer from the floor to the wheelchair. Conclusion The brSCIM-SR measures the degree of functionality, allowing health professionals and the patient to quantify and locate the items that indicate their deficits or gains during the rehabilitation process. Here, individuals with SCI showed good functional independence, with worse performance in the tetraplegia and recent injury groups: however, mobility showed partial dependence in the participants.
DOI: 10.6084/m9.figshare.21516365.v1
title: Functional independence analysis in persons with spinal cord injury

description: Abstract Introduction Spinal cord injury (SCI) radically changes a person’s life because of alterations in body dynamics, leading to disabilities and reduced functionality. Objective To analyze the functional independence of individuals with spinal cord injury and compare the groups. Methods Individuals with SCI were interviewed about their functional independence using the Brazilian version of the Spinal Cord Independence Measure - Self-Reported Version (brSCIM-SR) and later their respective domains and subdomains were compared between diagnostic groups, time since injury and sex. Results The sample consisted of fifty individuals aged 40.92 ± 13.93 years, predominantly men and diagnosed with paraplegia. In most brSCIM-SR domains, all respondents achieved good independence in self-care, respiration and sphincter management, and in the total brSCIM-SR, except for mobility. In paraplegia, chronic SCIs and both sexes achieved excellent independence in most subdomains and in the total. Significantly low values were found for tetraplegia and recent SCI in the self-care subdomain. In most subdomains, tetraplegia reached significantly lower values. In the subdomains of respiration and sphincter management, the participants were independent in the breathing function, but in tetraplegia, they showed significant dependence on transfer to the toilet. In terms of mobility, there was great dependence on the items going up and down stairs and transfer from the floor to the wheelchair. Conclusion The brSCIM-SR measures the degree of functionality, allowing health professionals and the patient to quantify and locate the items that indicate their deficits or gains during the rehabilitation process. Here, individuals with SCI showed good functional independence, with worse performance in the tetraplegia and recent injury groups: however, mobility showed partial dependence in the participants.
DOI: 10.6084/m9.figshare.21516369
title: Inheritance of beta-carotene content in melon

description: Abstract The objective of this work was to determine the inheritance of beta-carotene content in melon (Cucumis melo). The AC-16 accession (Cucumis melo subsp. melo var. acidulus) – with a low beta-carotene content and white mesocarp – was crossed with the Vedrantais cultivar (C. melo subsp. melo var. cantalupensis) – with a high beta-carotene content and salmon colored mesocarp –, to obtain the F1, F2, BC1, and BC2 generations. The AC-16 and 'Vedrantais' parents, the F1 and F2 generations, and the BC1 and BC2 backcrosses of each parent were evaluated. The quantification of beta-carotene was carried out in a high-performance liquid chromatography system. Mean components related to the additive and dominance effects, additive and dominance variances, and heritability were estimated. The beta-carotene content was high in 'Vedrantais' (17.78 µg g-1) and low in AC-16 (0.34 µg g-1). The following results were observed: additive and dominance effects on the genetic control of the character, incomplete character dominance, estimated number of loci close to two, greater variance for segregating populations (F2 and backcrosses), and heritability values in the broad (87.75%) and narrow (64.19%) senses. The beta-carotene content in melon is controlled by a major effect gene, with additive and dominance effects associated with polygenes with additive effects.
DOI: 10.6084/m9.figshare.21516369.v1
title: Inheritance of beta-carotene content in melon

description: Abstract The objective of this work was to determine the inheritance of beta-carotene content in melon (Cucumis melo). The AC-16 accession (Cucumis melo subsp. melo var. acidulus) – with a low beta-carotene content and white mesocarp – was crossed with the Vedrantais cultivar (C. melo subsp. melo var. cantalupensis) – with a high beta-carotene content and salmon colored mesocarp –, to obtain the F1, F2, BC1, and BC2 generations. The AC-16 and 'Vedrantais' parents, the F1 and F2 generations, and the BC1 and BC2 backcrosses of each parent were evaluated. The quantification of beta-carotene was carried out in a high-performance liquid chromatography system. Mean components related to the additive and dominance effects, additive and dominance variances, and heritability were estimated. The beta-carotene content was high in 'Vedrantais' (17.78 µg g-1) and low in AC-16 (0.34 µg g-1). The following results were observed: additive and dominance effects on the genetic control of the character, incomplete character dominance, estimated number of loci close to two, greater variance for segregating populations (F2 and backcrosses), and heritability values in the broad (87.75%) and narrow (64.19%) senses. The beta-carotene content in melon is controlled by a major effect gene, with additive and dominance effects associated with polygenes with additive effects.
DOI: 10.5281/zenodo.7302736
title: Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

description: Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in both wild-type and genetic epilepsy model rats were markedly augmented in response to the prolonged inhibition of CaMKII, indicating that the inactivation of CaMKII enhanced the neuronal excitability. Electrophysiological recording showed that CaMKII inhibition induced hyperexcitability of cultured hippocampal neurons and potentiation of neuronal activity in induced pluripotent stem cell (iPSC)-derived cortical neurons. We further revealed that CaMKII inhibition enhanced the persistent slow inactivating sodium current (I<sub>NaP</sub>) of hippocampal neurons, which was attributed to increased neuronal expression of the voltage-gated sodium channel Na<sub>V</sub>1.2. Our findings suggest that Na<sub>V</sub>1.2 expression was transcriptionally upregulated by the negative regulator nuclear receptor subfamily 4 group A member 2 (<em>NR4A2</em>). Furthermore, CaMKII inhibition induced interaction between Na<sub>V</sub>1.2 and CaM through immunoprecipitation assay. Intriguingly, a peptide that antagonized the binding of CaM to the IQ domain of Na<sub>V</sub>1.2 prevented neuronal hyperexcitability induced by CaMKII inhibition <em>in vivo</em> and <em>in vitro</em>. Altogether, we unveil that prolonged CaMKII inhibition leads to hyperexcitability through increasing the expression of Na<sub>V</sub>1.2 and its association with CaM. Thus, our study uncovers a novel signaling mechanism by which CaMKII maintains to appropriate neuronal excitability.
DOI: 10.5281/zenodo.6772856
title: Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

description: Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in both wild-type and genetic epilepsy model rats were markedly augmented in response to the prolonged inhibition of CaMKII, indicating that the inactivation of CaMKII enhanced the neuronal excitability. Electrophysiological recording showed that CaMKII inhibition induced hyperexcitability of cultured hippocampal neurons and potentiation of neuronal activity in induced pluripotent stem cell (iPSC)-derived cortical neurons. We further revealed that CaMKII inhibition enhanced the persistent slow inactivating sodium current (I<sub>NaP</sub>) of hippocampal neurons, which was attributed to increased neuronal expression of the voltage-gated sodium channel Na<sub>V</sub>1.2. Our findings suggest that Na<sub>V</sub>1.2 expression was transcriptionally upregulated by the negative regulator nuclear receptor subfamily 4 group A member 2 (<em>NR4A2</em>). Furthermore, CaMKII inhibition induced interaction between Na<sub>V</sub>1.2 and CaM through immunoprecipitation assay. Intriguingly, a peptide that antagonized the binding of CaM to the IQ domain of Na<sub>V</sub>1.2 prevented neuronal hyperexcitability induced by CaMKII inhibition <em>in vivo</em> and <em>in vitro</em>. Altogether, we unveil that prolonged CaMKII inhibition leads to hyperexcitability through increasing the expression of Na<sub>V</sub>1.2 and its association with CaM. Thus, our study uncovers a novel signaling mechanism by which CaMKII maintains to appropriate neuronal excitability.
DOI: 10.6084/m9.figshare.21516374
title: Use of the Bayley III Child Development Rating Scale in Brazilian Children: A Systematic Review

description: Abstract The objective of this study was to conduct a systematic review of Bayley III scale surveys in Brazilian children. The PRISMA recommendations were followed, with searches in the MEDLINE, LILACS, SCIELO, Scopus, PUBMED and Web of Science databases. The review included articles published in the Portuguese and English languages between 2006 and 2018. A total of 856 studies were found after the title and abstract analysis, and 24 were selected. The studies evaluated the development of preterm, typical, daycare, and atypical children, being the majority resident in the Southeast region and up to 12 months of age. The literature pointed to the prevalence of risk factors and high percentages of suspected and delayed neuropsychomotor development among the Brazilian children evaluated.