cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13174491
title: Petrogenesis of the Late Triassic Mengsong strongly peraluminous granites in the southeastern Tibetan Plateau: highly fractionated from crystal mush

description: The Triassic Lincang granites make up the largest peraluminous granitic batholith in the Changning-Menglian Paleo-Tethys orogenic belt, southeastern Tibetan Plateau. It is undoubtedly very important to investigate the role of crustal magmatism in the evolution of the Changning-Menglian Paleo-Tethys orogenic belt. The Late Triassic Mengsong pluton is composed of strongly peraluminous two-mica monzogranites, and is located in the southernmost part of the Lincang batholith. Despite all being peraluminous granites, they differ markedly in dimensions, petrographic and geochemical characteristics. Mengsong two-mica monzogranites have low contents of TiO<sub>2</sub>, FeO<sup>tot</sup>, MgO, and CaO, but high values of SiO<sub>2</sub> and Na<sub>2</sub>O, compared to biotite monzogranites of the Lincang batholith. The Lincang biotite monzogranites show an enrichment in light rare earth elements (LREE) and weak Eu anomalies (δEu = 0.3–0.8). However, the Mengsong two-mica monzogranites show a clear tetrad effect and contain pronounced negative Eu anomalies (δEu = 0.1–0.3). Geochemical compositions and mineral textures of two-mica monzogranites indicate that they are of highly fractionated type affinity. The two-mica monzogranites are characterized by negative <i>ε<sub>Hf</sub></i> (<i>t</i>) values (−9.3 to −1.7) and <i>ε<sub>Nd</sub></i> (<i>t</i>) values (−9.6 to −7.9), while the biotite monzogranites have lower <i>ε<sub>Hf</sub></i> (<i>t</i>) values (−15.5 to −6.1) and <i>ε<sub>Nd</sub></i> (<i>t</i>) values (−14.5 to −11.5). Isotopic compositions suggest that they were cogenetic and derived from partial melting of the lower crust. Our petrogenetic and zircon U–Pb age data support models that relate the Lincang and Mengsong granites to post-collisional magmatism in the Changning-Menglian Paleo-Tethys orogenic belt during the Middle to Late Triassic. We interpret the Mengsong pluton to represent highly fractionated melts from crystal mush reservoirs and the Lincang granites to be complementary residual.
DOI: 10.5517/ccdc.csd.cc27b44w
title: CCDC 2065317: Experimental Crystal Structure Determination

description: Related Article: Shih-Ching Chuang|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc27b43v
title: CCDC 2065316: Experimental Crystal Structure Determination

description: Related Article: Shih-Ching Chuang|2022|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc27j879
title: CCDC 2071210: Experimental Crystal Structure Determination

description: Related Article: Hee-Seung Lee, Byung-Chang Oh, Jaewook Kim|2021|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc27j914
title: CCDC 2071235: Experimental Crystal Structure Determination

description: Related Article: Hee-Seung Lee, Byung-Chang Oh, Jaewook Kim|2021|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc27j9y1
title: CCDC 2071263: Experimental Crystal Structure Determination

description: Related Article: Hee-Seung Lee, Byung-Chang Oh, Jaewook Kim|2021|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.22602530.v1
title: Additional file 2 of Combining a machine-learning derived 4-lncRNA signature with AFP and TNM stages in predicting early recurrence of hepatocellular carcinoma

description: Additional file 2. Table S1. Clinical characteristic of 314 TCGA-LIHC patients. Table S2. Differentially expressed lncRNAs associated with DFS. Table S3. Primers used in RT qPCR. Table S4. Drugs respond differently in the low- and high-risk group HCC patients. Table S5. Clinical characteristic of 24 HCC patients from Jinling cohort.
DOI: 10.6084/m9.figshare.22602494.v1
title: Additional file 1 of HIV infection disclosure, treatment self-efficacy and quality of life in HIV-infected MSM receiving antiretroviral therapy

description: Additional file 1: Table S1. Socio-demographic characteristics and relationships with QOL and its various domains a (n = 579). Table S2. Multivariable analyses with HIV treatment self-efficacy and overall QOL as outcomes. Table S3. Multivariable analyses with HIV treatment self-efficacy and physical as outcomes. Table S4. Multivariable analyses with HIV treatment self-efficacy and psychological as outcomes. Table S5. Multivariable analyses with HIV treatment self-efficacy and independence as outcomes. Table S6. Multivariable analyses with HIV treatment self-efficacy and environment as outcomes. Table S7. Multivariable analyses with HIV treatment self-efficacy and spirituality as outcomes.
DOI: 10.6084/m9.figshare.22606688.v1
title: Additional file 2 of Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression

description: Additional file 2: Table S3. Differential peaks within mRNA transcipts between NAT10 KO and the control cells.
DOI: 10.6084/m9.figshare.20509821.v1
title: LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

description: The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through <i>in vivo</i> and <i>in vitro</i> experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 <i>in vitro</i>. In addition, luciferase reporter assays were performed to confirm the binding site. The expression levels of miR-383 and VEGFA in tumor cells were measured using reverse transcription-quantitative PCR. HCC-78 was also transfected with miR-383 mimics, inhibitors and siRNA-VEGFA before their viability was also assessed. Xenograft models were established in nude mice to investigate the tumor characteristics <i>in vivo</i>. The expression of lncRNA-UCA1 was significantly increased in tumor tissues and cells compared with adjacent tissues or HBE cells. Silencing lncRNA-UCA1 expression in cells resulted in a reduction in lung cancer cell viability. In addition, lncRNA-UCA1 silencing increased the expression of miR-383. Inhibiting miR-383 expression increased HCC-78 proliferation, migration and invasion, whilst reducing their apoptosis. miR-383 was shown to specifically target VEGFA to inhibit its expression at both the protein and mRNA levels. VEGFA knockdown resulted in a reduction in all aforementioned aspects of HCC-78 cell activity. In addition, inhibiting miR-383 expression led to larger tumor sizes <i>in vivo</i>. To conclude, the results of the study suggest that lncRNA-UCA1 can regulate the expression of miR-383 and, in turn, VEGFA.
DOI: 10.4121/f2aa4e23-3779-4b80-9fb5-c97a82f73633
title: Analysis output from: Potential of boreholes combined with deep-rooted cover crops to ameliorate subsoil compaction

description: Due to climate change longer periods of drought and high precipitation in short periods of time will become more common. Subsoil compaction causes cropland to be less resilient to such changes due to worse root growth, water infiltration and less capillary rise of water. There is a lack of measures to ameliorate subsoil compaction. Two experiments were performed where the potential of different types of boreholes were compared to deep subsoiling and an untreated reference. Effects on soil structure and crop productivity were analyzed. Data and scripts are not provided, only HTML output files.
DOI: 10.6084/m9.figshare.22602494
title: Additional file 1 of HIV infection disclosure, treatment self-efficacy and quality of life in HIV-infected MSM receiving antiretroviral therapy

description: Additional file 1: Table S1. Socio-demographic characteristics and relationships with QOL and its various domains a (n = 579). Table S2. Multivariable analyses with HIV treatment self-efficacy and overall QOL as outcomes. Table S3. Multivariable analyses with HIV treatment self-efficacy and physical as outcomes. Table S4. Multivariable analyses with HIV treatment self-efficacy and psychological as outcomes. Table S5. Multivariable analyses with HIV treatment self-efficacy and independence as outcomes. Table S6. Multivariable analyses with HIV treatment self-efficacy and environment as outcomes. Table S7. Multivariable analyses with HIV treatment self-efficacy and spirituality as outcomes.
DOI: 10.6084/m9.figshare.22606850
title: Additional file 2 of Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma

description: Additional file 2. The list of DEGs comparing pre- and post-treatment samples in each immnue cell type.
DOI: 10.6084/m9.figshare.22606850.v1
title: Additional file 2 of Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma

description: Additional file 2. The list of DEGs comparing pre- and post-treatment samples in each immnue cell type.
DOI: 10.6084/m9.figshare.25164689
title: Supplementary Material for: Complexities in Adjuvant Endocrine Therapy for Breast Cancer in Female-to-Male Transgender Patients

description: <b><i>Introduction:</i></b> Managing breast cancer in female-to-male (FtM) transgender patients is complicated and challenging. Androgens play a crucial role in the development of secondary sexual identity in FtM transgender patients, but their effectiveness in breast cancer remains unclear. Furthermore, the considerations for adjuvant endocrine therapy in this population are highly intricate and warrant thorough discussion. <b><i>Case Presentation:</i></b> We describe the case of a 44-year-old FtM transgender diagnosed with breast cancer 3 years after initiating androgen receptor agonist therapy as part of his gender identity transition. After mastectomy, adjuvant endocrine therapy was initiated, consisting of a combination of an aromatase inhibitor and a gonadotropin-releasing hormone agonist, along with a cross-sex hormone. <b><i>Conclusion:</i></b> Estradiol levels were significantly reduced, and male-typical levels of sex hormones were attained.
DOI: 10.6084/m9.figshare.20509782
title: Structural and geochronological constraints on a Late Mesozoic tectonic transformation in the West Qinling Orogenic Belt, China

description: The Qinling Orogenic Belt was formed by multi-stage convergence and subsequent collision between the North China Block and South China Block during the Palaeozoic to Late Triassic. Following the collision between the South Qinling Belt and the South China Block in the Late Triassic, the whole Qinling Orogenic Belt evolved into an intracontinental orogeny. However, the exact termination time of the Late Mesozoic intracontinental contractional deformation and the tectonic transformation from compression to extension remains unclear. The extensional shear zone developed in the West Qinling Orogenic Belt provides a crucial clue to revealing the tectonic transformation and uplift and exhumation of the orogenic belt. This study focuses on kinematics, deformation temperature, and geochronology of the shear zone in the West Qinling Orogenic Belt through detailed field structural analysis and laboratory analysis. The Taibai shear zone (TBSZ), located in the West Qinling Orogenic Belt, cuts across the Qinling Orogenic Belt along the NE–NEE direction and separates the Taibai pluton in the east from the Baoji pluton in the west. The NE–NEE-striking TBSZ is an extensional shear zone showing a top-to-the-NW sinistral shear sense. The TBSZ was formed under the high greenschist–low amphibolite facies conditions (300–550°C) in the middle-upper crust level (8–15 km). Zircon U–Pb dating and biotite and muscovite <sup>40</sup>Ar/<sup>39</sup>Ar dating indicate that the TBSZ occurred at 120–113 Ma. The extensional TBSZ and normal faults on its hanging wall indicate the tectonic transformation and the extensional collapse of the Mesozoic intracontinental orogenic belt during the late Early Cretaceous. The Cretaceous extensional collapse of the Qinling Orogenic Belt also led to the rapid uplift and exhumation of the Taibai pluton and the North Qinling Belt in the east.
DOI: 10.6084/m9.figshare.20509821
title: LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

description: The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through <i>in vivo</i> and <i>in vitro</i> experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 <i>in vitro</i>. In addition, luciferase reporter assays were performed to confirm the binding site. The expression levels of miR-383 and VEGFA in tumor cells were measured using reverse transcription-quantitative PCR. HCC-78 was also transfected with miR-383 mimics, inhibitors and siRNA-VEGFA before their viability was also assessed. Xenograft models were established in nude mice to investigate the tumor characteristics <i>in vivo</i>. The expression of lncRNA-UCA1 was significantly increased in tumor tissues and cells compared with adjacent tissues or HBE cells. Silencing lncRNA-UCA1 expression in cells resulted in a reduction in lung cancer cell viability. In addition, lncRNA-UCA1 silencing increased the expression of miR-383. Inhibiting miR-383 expression increased HCC-78 proliferation, migration and invasion, whilst reducing their apoptosis. miR-383 was shown to specifically target VEGFA to inhibit its expression at both the protein and mRNA levels. VEGFA knockdown resulted in a reduction in all aforementioned aspects of HCC-78 cell activity. In addition, inhibiting miR-383 expression led to larger tumor sizes <i>in vivo</i>. To conclude, the results of the study suggest that lncRNA-UCA1 can regulate the expression of miR-383 and, in turn, VEGFA.
DOI: 10.5522/04/25145096
title: Grids for Photopic, Mesopic and Scotopic Microperimetry in the MP3-S device

description: These are the grids we propose for performing sequential photopic, mesopic and scotopic in the MP3-S microperimetry device (Nidek, Gamagori, Japan). The name of the specific configuration and grids we have used herein is MGT020 followed by the modality (MGT020 Photo, Meso or Scoto).All these .xml files can be imported directly to the device via the Pattern Editor in the NAVIS-EX software.The testing configurations we used are as follows:For the purposes of this protocol, we developed two custom grids: a 32-point grid to be used for photopic and mesopic, and another 28-point grid to be used in scotopic testing. Both grids test the central 10 degrees of the macula (10-2).In photopic and mesopic testing, a Goldmann size III stimulus with 200 ms duration was used in a 4-2 strategy, on a background luminance of 31.4 asb (9.99 cd/m²) for photopic, and 4 asb (1.27 cd/m²) for mesopic. The fixation target was a 1-degree size red cross. The dynamic range of the device in these modalities is 34 dB.In scotopic testing, the grid is composed of 28 points – the same 32 points used in mesopic/photopic testing minus the four positions within 2 degrees of the fovea (rod-free zone; marked as points 1, 9, 17 and 25 in Figure 1A). A Goldmann size V stimulus with 200 ms duration in a 4-2 strategy, and a background luminance of 0.003 asb (0.0009 cd/m²) was used. The dynamic range of the device in scotopic setting is 24 dB.
DOI: 10.5522/04/25145096.v1
title: Grids for Photopic, Mesopic and Scotopic Microperimetry in the MP3-S device

description: These are the grids we propose for performing sequential photopic, mesopic and scotopic in the MP3-S microperimetry device (Nidek, Gamagori, Japan). The name of the specific configuration and grids we have used herein is MGT020 followed by the modality (MGT020 Photo, Meso or Scoto).All these .xml files can be imported directly to the device via the Pattern Editor in the NAVIS-EX software.The testing configurations we used are as follows:For the purposes of this protocol, we developed two custom grids: a 32-point grid to be used for photopic and mesopic, and another 28-point grid to be used in scotopic testing. Both grids test the central 10 degrees of the macula (10-2).In photopic and mesopic testing, a Goldmann size III stimulus with 200 ms duration was used in a 4-2 strategy, on a background luminance of 31.4 asb (9.99 cd/m²) for photopic, and 4 asb (1.27 cd/m²) for mesopic. The fixation target was a 1-degree size red cross. The dynamic range of the device in these modalities is 34 dB.In scotopic testing, the grid is composed of 28 points – the same 32 points used in mesopic/photopic testing minus the four positions within 2 degrees of the fovea (rod-free zone; marked as points 1, 9, 17 and 25 in Figure 1A). A Goldmann size V stimulus with 200 ms duration in a 4-2 strategy, and a background luminance of 0.003 asb (0.0009 cd/m²) was used. The dynamic range of the device in scotopic setting is 24 dB.
DOI: 10.6084/m9.figshare.20509782.v1
title: Structural and geochronological constraints on a Late Mesozoic tectonic transformation in the West Qinling Orogenic Belt, China

description: The Qinling Orogenic Belt was formed by multi-stage convergence and subsequent collision between the North China Block and South China Block during the Palaeozoic to Late Triassic. Following the collision between the South Qinling Belt and the South China Block in the Late Triassic, the whole Qinling Orogenic Belt evolved into an intracontinental orogeny. However, the exact termination time of the Late Mesozoic intracontinental contractional deformation and the tectonic transformation from compression to extension remains unclear. The extensional shear zone developed in the West Qinling Orogenic Belt provides a crucial clue to revealing the tectonic transformation and uplift and exhumation of the orogenic belt. This study focuses on kinematics, deformation temperature, and geochronology of the shear zone in the West Qinling Orogenic Belt through detailed field structural analysis and laboratory analysis. The Taibai shear zone (TBSZ), located in the West Qinling Orogenic Belt, cuts across the Qinling Orogenic Belt along the NE–NEE direction and separates the Taibai pluton in the east from the Baoji pluton in the west. The NE–NEE-striking TBSZ is an extensional shear zone showing a top-to-the-NW sinistral shear sense. The TBSZ was formed under the high greenschist–low amphibolite facies conditions (300–550°C) in the middle-upper crust level (8–15 km). Zircon U–Pb dating and biotite and muscovite <sup>40</sup>Ar/<sup>39</sup>Ar dating indicate that the TBSZ occurred at 120–113 Ma. The extensional TBSZ and normal faults on its hanging wall indicate the tectonic transformation and the extensional collapse of the Mesozoic intracontinental orogenic belt during the late Early Cretaceous. The Cretaceous extensional collapse of the Qinling Orogenic Belt also led to the rapid uplift and exhumation of the Taibai pluton and the North Qinling Belt in the east.
DOI: 10.6084/m9.figshare.17893681
title: Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells

description: Chrysin, a natural compound isolated from various plants, such as the blue passion flower (<i>Passiflora caerulea L</i>.), exhibits multiple pharmacological activities, such as antitumor, anti-inflammatory and antioxidant activities. Accumulating evidence shows that chrysin inhibits cancer cell growth by inducing apoptosis and regulating cell cycle arrest. However, whether chrysin is involved in regulating genomic stability and its underlying mechanisms in breast cancer cells have not been determined. Here, we demonstrated that chrysin impairs genomic stability in MCF-7 and BT474 cells, inhibits cell survival and enhances the sensitivity of MCF-7 cells to chemotherapeutic drugs. Further experiments revealed that chrysin impairs DNA double-strand break (DSB) repair, resulting in accumulation of DNA damage. Mechanistic studies showed that chrysin inhibits the recruitment of the key NHEJ factor 53BP1 and delays the recruitment of the HR factor RAD51. Thus, we elucidated novel regulatory mechanisms of chrysin in DSB repair and proposed that a combination of chrysin and chemotherapy has curative potential in breast cancers.
DOI: 10.6084/m9.figshare.22606931.v1
title: Additional file 10 of EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells

description: Additional file 10. Correlation analysis between differentially expressed TFs and the validated UPR-related genes.
DOI: 10.6084/m9.figshare.22606934.v1
title: Additional file 11 of EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells

description: Additional file 11. Correlation analysis between DEGs and EIF5A2 in human glial cell tissue database.
DOI: 10.6084/m9.figshare.22606898.v1
title: Additional file 1 of EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells

description: Additional file 1. Primers sequence. Information of primers used in RT-qPCR experiments throughout the present study.
DOI: 10.6084/m9.figshare.22606901.v1
title: Additional file 2 of EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells

description: Additional file 2. RNA-seq reads of SH-SY5Y cells from control group and EIF5A2-OE group.