cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.23645/epacomptox.9925151.v2
title: Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals

description: Time courses of compound concentrations in plasma are used in chemical safety analysis to evaluate the relationship between external administered doses and internal tissue exposures. This type of experimental data is rarely available for the thousands of non-pharmaceutical chemicals to which people may potentially be unknowingly exposed but is necessary to properly assess the risk of such exposures. In vitro assays and in silico models are often used to craft an understanding of a chemical’s pharmacokinetics; however, the certainty of the quantitative application of these estimates for chemical safety evaluations cannot be determined without in vivo data for external validation. To address this need, we present a public database of chemical time-series concentration data from 567 studies in humans or test animals for 144 environmentally-relevant chemicals and their metabolites (187 analytes total). All major administration routes are incorporated, with concentrations measured in blood/plasma, tissues, and excreta . We also include calculated pharmacokinetic parameters for some studies, and a bibliography of additional source documents to support future extraction of time-series. In addition to pharmacokinetic model calibration and validation, these data may be used for analyses of differential chemical distribution across chemicals, species, doses, or routes, and for meta-analyses on pharmacokinetic studies.
DOI: 10.6084/m9.figshare.9925037.v1
title: Metadata record for: Structural and functional multi-platform MRI series of a single human volunteer over more than fifteen years

description: This dataset contains key characteristics about the data described in the Data Descriptor Structural and functional multi-platform MRI series of a single human volunteer over more than fifteen years. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br><br>Versioning Note:<br>A revised version was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.9924935
title: Edwards_Supplemental Table Summary of Echo Data.pdf

description: Echocardiography data set for rats treated with doxorubicin
DOI: 10.6084/m9.figshare.9925046.v1
title: A multi-arm cluster randomized clinical trial of the use of knee kinesiography in the management of osteoarthritis patients in a primary care setting

description: <b>Objective</b>: An important clinical gap reported by primary care physicians (PCPs) in managing knee osteoarthritis patients is the lack of validated tools to help them guide conservative treatment decision-making. This study aimed at evaluating the clinical utility of adding to current medical management (CMM) by PCPs, a dynamic knee kinesiography (KneeKG) exam assessing biomechanical risk factors linked to osteoarthritis progression. <b>Design</b>: In this 6-month cluster randomized controlled trial, primary care clinics were randomized into three groups: 1-CMM by PCPs, 2-CMM+KneeKG, and 3-CMM+KneeKG+Education (a self-management education session and two follow-up group meetings). Primary outcomes were scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales and overall score. <b>Results</b>: Of the 894 patients referred from 87 clinics, 515 participated, 449 (87.2%) completed the study. At 6-month follow-up, patients in both KneeKG groups reported statistically significant improvement on the KOOS overall score (Group2: +5.5; Group3: +5.0), and on the symptoms, pain, and activities of daily living subscales compared to control group (all p <b>Conclusions</b>: Results demonstrated significant improvements in terms of pain, function, and satisfaction in KneeKG groups relative to the CMM. Adding education and supervision further improves clinical outcomes. These findings may support the added value of a KneeKG exam in assisting PCPs in the management of knee osteoarthritis patients.
DOI: 10.6084/m9.figshare.9924935.v1
title: Edwards_Supplemental Table Summary of Echo Data.pdf

description: Echocardiography data set for rats treated with doxorubicin
DOI: 10.6084/m9.figshare.9924911
title: dataset for Repetitive Readout Enhanced by Machine Learning

description: For the paper titled "Repetitive Readout Enhanced by Machine Learning"<br>The folder name corresponds to simulated NV photodynamic parameters <br> training.mat includes data_plus (5000*8000), data_minus (2500*8000), data_zero (2500*8000), corresponding to 14N starting in +1 (dark state), -1 (bright state), 0 (bright state) state (+1 is the dark state) <br> test.mat includes data_test (4000*8000), the first 1000 is |mI=-1&gt;, second 1000 |mI=0&gt; (2000 bright states), and last 2000 |mI=+1&gt; state (dark state) <br> These data are directly from Monte Carlo simulation and does not consider detection efficiency, which is added later by add_detection_efficiency following binomial distribution.
DOI: 10.6084/m9.figshare.9924893
title: 100 Gamma Knife Meningioma Cases

description: 100 anonymized Leksell Gamma Plan meningioma radiosurgery treatment plans
DOI: 10.6084/m9.figshare.9924911.v1
title: dataset for Repetitive Readout Enhanced by Machine Learning

description: For the paper titled "Repetitive Readout Enhanced by Machine Learning"<br>The folder name corresponds to simulated NV photodynamic parameters <br> training.mat includes data_plus (5000*8000), data_minus (2500*8000), data_zero (2500*8000), corresponding to 14N starting in +1 (dark state), -1 (bright state), 0 (bright state) state (+1 is the dark state) <br> test.mat includes data_test (4000*8000), the first 1000 is |mI=-1&gt;, second 1000 |mI=0&gt; (2000 bright states), and last 2000 |mI=+1&gt; state (dark state) <br> These data are directly from Monte Carlo simulation and does not consider detection efficiency, which is added later by add_detection_efficiency following binomial distribution.
DOI: 10.6084/m9.figshare.9924677
title: Development of Walking indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project

description: <b>Objective:</b> To describe the development of structure, process and outcome indicators that will advance the quality of walking rehabilitation for Canadians with spinal cord injury or disease (SCI/D) by 2020. <b>Method:</b> A framework for the evaluation of the quality of walking rehabilitation was developed by experts in walking after SCI/D. A systematic literature review identified factors influencing walking outcomes and potential walking indicators. A Driver diagram analysis summarized the factors affecting walking outcomes and subsequently informed the selection of structure and process indicators. Psychometric properties and clinical utility of potential walking indicators were considered during the selection of outcome indicators. <b>Results:</b> The structure indicator is the number of physical therapists using evidence-based walking interventions per number of ambulatory individuals with SCI/D. The process indicator is the number of received hours of walking interventions during inpatient rehabilitation per number of ambulatory individuals with SCI/D. The intermediary outcome indicator, which is collected at discharge from inpatient rehabilitation, is either the modified Timed Up and Go or the 10-Meter Walk Test, the choice of measure is dictated by the stage of walking recovery, as defined by the Standing and Walking Assessment Tool. The final outcome indicator, collected at 18 months post-discharge, is the Spinal Cord Independence Measure III-Mobility subscale. <b>Conclusion:</b> The selected indicators align with current clinical practice in Canada. The indicators will direct the timing and enhance the volume of walking therapy delivered, to ultimately increase the proportion of patients who achieve their walking potential by 18 months post-rehabilitation.
DOI: 10.6084/m9.figshare.9924671
title: Prioritization of rehabilitation Domains for establishing spinal cord injury high performance indicators using a modification of the Hanlon method: SCI-High Project

description: <b>Objectives:</b> To prioritize Domains of SCI Rehabilitation Care (SCI-Care) based on clinical importance and feasibility to inform the development of indicators of quality SCI-Care for adults with SCI/D in Canada. <b>Methods:</b> A 17-member external advisory committee, comprised of key stakeholders, ranked 15/37 Domains of rehabilitation previously flagged by the E-scan project team for gaps between knowledge generation and clinical implementation. Priority scores (D) were calculated using the Hanlon formula: D=[A+(2×B)]×C, where A is prevalence, B is seriousness, and C is the effectiveness of available interventions. A modified “EAARS” (Economic, Acceptability, Accessibility, Resources, and Simplicity) criterion was used to rank feasibility on a scale of 0–4 (4 is high). The product of these two scores determined the initial Domain ranking. Following the consensus process, further changes were made to the Domain rankings. <b>Results:</b> Despite a low feasibility score, Sexual Health was ranked as high priority; and, the Community Participation and Employment Domains were merged. The 11 final prioritized Domains in alphabetic order were: Cardiometabolic Health; Community Participation and Employment; Emotional Well-Being; Reaching, Grasping, and Manipulation; Self-Management; Sexual Health; Tissue Integrity; Urinary Tract Infection; Urohealth; Walking, and Wheeled Mobility. <b>Conclusions:</b> The modified Hanlon method was used to facilitate prioritization of 11 of 37 Domains to advance the quality of SCI-care by 2020. In future, the Spinal Cord Injury Rehabilitation Care High Performance Indicators (SCI-High) Project Team will develop structure, process and outcome indicators for each prioritized Domain.
DOI: 10.6084/m9.figshare.9924677.v1
title: Development of Walking indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project

description: <b>Objective:</b> To describe the development of structure, process and outcome indicators that will advance the quality of walking rehabilitation for Canadians with spinal cord injury or disease (SCI/D) by 2020. <b>Method:</b> A framework for the evaluation of the quality of walking rehabilitation was developed by experts in walking after SCI/D. A systematic literature review identified factors influencing walking outcomes and potential walking indicators. A Driver diagram analysis summarized the factors affecting walking outcomes and subsequently informed the selection of structure and process indicators. Psychometric properties and clinical utility of potential walking indicators were considered during the selection of outcome indicators. <b>Results:</b> The structure indicator is the number of physical therapists using evidence-based walking interventions per number of ambulatory individuals with SCI/D. The process indicator is the number of received hours of walking interventions during inpatient rehabilitation per number of ambulatory individuals with SCI/D. The intermediary outcome indicator, which is collected at discharge from inpatient rehabilitation, is either the modified Timed Up and Go or the 10-Meter Walk Test, the choice of measure is dictated by the stage of walking recovery, as defined by the Standing and Walking Assessment Tool. The final outcome indicator, collected at 18 months post-discharge, is the Spinal Cord Independence Measure III-Mobility subscale. <b>Conclusion:</b> The selected indicators align with current clinical practice in Canada. The indicators will direct the timing and enhance the volume of walking therapy delivered, to ultimately increase the proportion of patients who achieve their walking potential by 18 months post-rehabilitation.
DOI: 10.6084/m9.figshare.9924665
title: Development of Wheeled Mobility indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project

description: <b>Background:</b> Wheeled mobility is critical for individuals with Spinal Cord Injury or Disease (SCI/D) related paralysis. The World Health Organization (WHO) developed guidelines highlighting eight steps in wheelchair service delivery: (1) referral and appointment; (2) assessment; (3) prescription; (4) funding and ordering; (5) product preparation; (6) fitting; (7) user training; and, (8) follow-up maintenance/repairs. This article describes the processes used to develop structure, process and outcome indicators that reflect the WHO guidelines within the Domain of Wheeled Mobility rehabilitation for Canadians. <b>Methods:</b> Wheeled mobility <b>e</b>xperts within the SCI-High Project Team used the WHO guideline to inform the Construct refinement and development of a Driver diagram. Following seven meetings, the Driver diagram and review of outcome measures and literature synthesis regarding wheelchair service delivery informed indicator selection and group consensus. <b>Results:</b> The structure indicator examines the proportion of SCI/D service providers within a rehabilitation program who have specialized wheelchair training to ensure prescription, preparation, fitting, and maintenance quality. The process indicator evaluates the average number of hours of wheelchair service delivery provided per patient during rehabilitation. The intermediary outcome indicator (rehabilitation discharge), is a target capacity score on the Wheelchair Skills Test Questionnaire (WST-Q). The final outcome indicators (at 18 months post rehabilitation admission) are the Life Space Assessment (LSA) and the Wheelchair Use Confidence Scale (WheelCon) short form mean scores. <b>Conclusion:</b> Routine implementation of the selected Wheeled Mobility structure, process and outcome indicators should measurably advance care within the Wheeled Mobility Domain for Canadians living with SCI/D by 2020.
DOI: 10.6084/m9.figshare.9924671.v1
title: Prioritization of rehabilitation Domains for establishing spinal cord injury high performance indicators using a modification of the Hanlon method: SCI-High Project

description: <b>Objectives:</b> To prioritize Domains of SCI Rehabilitation Care (SCI-Care) based on clinical importance and feasibility to inform the development of indicators of quality SCI-Care for adults with SCI/D in Canada. <b>Methods:</b> A 17-member external advisory committee, comprised of key stakeholders, ranked 15/37 Domains of rehabilitation previously flagged by the E-scan project team for gaps between knowledge generation and clinical implementation. Priority scores (D) were calculated using the Hanlon formula: D=[A+(2×B)]×C, where A is prevalence, B is seriousness, and C is the effectiveness of available interventions. A modified “EAARS” (Economic, Acceptability, Accessibility, Resources, and Simplicity) criterion was used to rank feasibility on a scale of 0–4 (4 is high). The product of these two scores determined the initial Domain ranking. Following the consensus process, further changes were made to the Domain rankings. <b>Results:</b> Despite a low feasibility score, Sexual Health was ranked as high priority; and, the Community Participation and Employment Domains were merged. The 11 final prioritized Domains in alphabetic order were: Cardiometabolic Health; Community Participation and Employment; Emotional Well-Being; Reaching, Grasping, and Manipulation; Self-Management; Sexual Health; Tissue Integrity; Urinary Tract Infection; Urohealth; Walking, and Wheeled Mobility. <b>Conclusions:</b> The modified Hanlon method was used to facilitate prioritization of 11 of 37 Domains to advance the quality of SCI-care by 2020. In future, the Spinal Cord Injury Rehabilitation Care High Performance Indicators (SCI-High) Project Team will develop structure, process and outcome indicators for each prioritized Domain.
DOI: 10.6084/m9.figshare.9924662
title: Data to reproduce R codes

description: Contains the variables required to reproduce results from "Complementarity effects are strengthened by competition intensity and global environmental change in the central boreal forests of Canada.". Columns included, in order: Unique Plot Identification, unique tree identification,species of the tree, shade tolerance of the tree, growth from prior interval of the tree, competition experienced by the tree, middle year of measurement period, phylogenetic dissimilarity to neighbours on a 12.6m radius, phylogenetic dissimilarity to neighbours on a 10m radius, shade tolerance dissimilarity to neighbours on a 12.6m radius, shade tolerance dissimilarity to neighbours on a 10m radius, age, atmospheric CO2 for census period, annual temperature anomaly for census period, and standardised precipitation-evapotranspiration index for census period.
DOI: 10.6084/m9.figshare.9924665.v1
title: Development of Wheeled Mobility indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project

description: <b>Background:</b> Wheeled mobility is critical for individuals with Spinal Cord Injury or Disease (SCI/D) related paralysis. The World Health Organization (WHO) developed guidelines highlighting eight steps in wheelchair service delivery: (1) referral and appointment; (2) assessment; (3) prescription; (4) funding and ordering; (5) product preparation; (6) fitting; (7) user training; and, (8) follow-up maintenance/repairs. This article describes the processes used to develop structure, process and outcome indicators that reflect the WHO guidelines within the Domain of Wheeled Mobility rehabilitation for Canadians. <b>Methods:</b> Wheeled mobility <b>e</b>xperts within the SCI-High Project Team used the WHO guideline to inform the Construct refinement and development of a Driver diagram. Following seven meetings, the Driver diagram and review of outcome measures and literature synthesis regarding wheelchair service delivery informed indicator selection and group consensus. <b>Results:</b> The structure indicator examines the proportion of SCI/D service providers within a rehabilitation program who have specialized wheelchair training to ensure prescription, preparation, fitting, and maintenance quality. The process indicator evaluates the average number of hours of wheelchair service delivery provided per patient during rehabilitation. The intermediary outcome indicator (rehabilitation discharge), is a target capacity score on the Wheelchair Skills Test Questionnaire (WST-Q). The final outcome indicators (at 18 months post rehabilitation admission) are the Life Space Assessment (LSA) and the Wheelchair Use Confidence Scale (WheelCon) short form mean scores. <b>Conclusion:</b> Routine implementation of the selected Wheeled Mobility structure, process and outcome indicators should measurably advance care within the Wheeled Mobility Domain for Canadians living with SCI/D by 2020.
DOI: 10.5522/04/9924593
title: Cleaned data arising from the KMunicate study

description: Dataset (Stata V14 format) containing responses to the KMunicate survey (https://bmjopen.bmj.com/content/9/9/e030215.full).<br>De-identification necessarily required removal of some of the descriptive variables used by the authors, including free-text comments (some comments made participants identifiable) and country (continent is retained).<br>The dataset contains descriptive information on the trial that was assessed, the participant's continent, their primary role, whether or not they act as an editor for a journal, and their experience reading and producing Kaplan–Meier plots.The remainder of the data is responses to the proposals. First, how 'useful' they felt each proposal was, as compared with the 'vanilla' plot, and then their ranking of the proposals.<br>
DOI: 10.6084/m9.figshare.9924662.v1
title: Data to reproduce R codes

description: Contains the variables required to reproduce results from "Complementarity effects are strengthened by competition intensity and global environmental change in the central boreal forests of Canada.". Columns included, in order: Unique Plot Identification, unique tree identification,species of the tree, shade tolerance of the tree, growth from prior interval of the tree, competition experienced by the tree, middle year of measurement period, phylogenetic dissimilarity to neighbours on a 12.6m radius, phylogenetic dissimilarity to neighbours on a 10m radius, shade tolerance dissimilarity to neighbours on a 12.6m radius, shade tolerance dissimilarity to neighbours on a 10m radius, age, atmospheric CO2 for census period, annual temperature anomaly for census period, and standardised precipitation-evapotranspiration index for census period.
DOI: 10.5522/04/9924593.v1
title: Cleaned data arising from the KMunicate study

description: Dataset (Stata V14 format) containing responses to the KMunicate survey (https://bmjopen.bmj.com/content/9/9/e030215.full).<br>De-identification necessarily required removal of some of the descriptive variables used by the authors, including free-text comments (some comments made participants identifiable) and country (continent is retained).<br>The dataset contains descriptive information on the trial that was assessed, the participant's continent, their primary role, whether or not they act as an editor for a journal, and their experience reading and producing Kaplan–Meier plots.The remainder of the data is responses to the proposals. First, how 'useful' they felt each proposal was, as compared with the 'vanilla' plot, and then their ranking of the proposals.<br>
DOI: 10.6084/m9.figshare.9924527
title: Assay_Data

description: Assay Data form paper see comments
DOI: 10.6084/m9.figshare.9924527.v1
title: Assay_Data

description: Assay Data form paper see comments
DOI: 10.15131/shef.data.9924485
title: Data for: Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease: Contribution of behavioural symptoms [to be published in PLoS One]

description: A speadsheet of data from two groups, a Parkinson's disease group and a group of controls matched for age, gender and years in education. Both groups completed questionnaire measures (HADS, QUIP-RS, TOSCA, BIS-11, Self-Disgust Scale), and responded to questions about how they felt following two induction paradigms. In the first paradigm, they were shown photographs of themselves (or a neutral photograph) and were asked to report levels of self-disgust, anger, sadness and the levels of arousal. In the second paradigm, they were asked to narrate instances when they had felt self-disgust, shame, guilt or a neutral mood, and report how they felt after the narration (in terms of the target emotion, anger, sadness, happiness, and the level of arousal).<br>Ethical permission was granted for the work by by the University Research Ethics Committee (although there is no reference number for the approval).<br>
DOI: 10.15131/shef.data.9924485.v1
title: Data for: Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease: Contribution of behavioural symptoms [to be published in PLoS One]

description: A speadsheet of data from two groups, a Parkinson's disease group and a group of controls matched for age, gender and years in education. Both groups completed questionnaire measures (HADS, QUIP-RS, TOSCA, BIS-11, Self-Disgust Scale), and responded to questions about how they felt following two induction paradigms. In the first paradigm, they were shown photographs of themselves (or a neutral photograph) and were asked to report levels of self-disgust, anger, sadness and the levels of arousal. In the second paradigm, they were asked to narrate instances when they had felt self-disgust, shame, guilt or a neutral mood, and report how they felt after the narration (in terms of the target emotion, anger, sadness, happiness, and the level of arousal).<br>Ethical permission was granted for the work by by the University Research Ethics Committee (although there is no reference number for the approval).<br>