cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.34973/45cm-3w75
title: What are sustainable plastics? A review of interrelated problems and solutions to help avoid unintended consequences

description: The data were collected for a research project that lead to the publication of Gonella, S., & de Gooyert, V. (2024). What are sustainable plastics? A review of interrelated problems and solutions to help avoid unintended consequences. Environmental Research Letters, 19(7), 073001–073001. https://doi.org/10.1088/1748-9326/ad536d.

Plastics are affordable and versatile, but there is a growing awareness that they are unsustainable in a number of ways, including concerns about climate, health and biodiversity. A number of solutions are being explored that could enable a more sustainable plastics system. So far, most research has focused on isolated technical solutions that address only one specific sustainability challenge posed by plastics, such as end-of-life management or feedstock alternatives to fossil fuels. Some interventions might mitigate one problem but contribute to another at a different stage of the plastics life cycle. This study is based on a literature review and adopts qualitative system dynamics to analyse the unsustainability of plastics with a holistic, integrative approach. The paper provides an overview of the impacts of potential solutions on the plastics system, highlighting how some interventions could end up having unintended consequences, perhaps even overshadowing the benefits. 

The READ ME file explains in more detail what kind of data is included in this collection and the methodology used to extrapolate data from the literature and build qualitative system dynamics models. More specifically, this collection includes: a list of relevant literature; an explanation of how these documents were coded; the qualitative system dynamics models obtained.
DOI: 10.34973/erx4-sg63
title: What are sustainable plastics? A review of interrelated problems and solutions to help avoid unintended consequences

description: The data were collected for a research project that lead to the publication of Gonella, S., & de Gooyert, V. (2024). What are sustainable plastics? A review of interrelated problems and solutions to help avoid unintended consequences. Environmental Research Letters, 19(7), 073001–073001. https://doi.org/10.1088/1748-9326/ad536d.

This Data Acquisition Collection (DAC) stores data that was not possible to include in the corresponding Data Sharing Collection (DSC) (DOI: https://doi.org/10.34973/45cm-3w75) because of copyright reasons.

Plastics are affordable and versatile, but there is a growing awareness that they are unsustainable in a number of ways, including concerns about climate, health and biodiversity. A number of solutions are being explored that could enable a more sustainable plastics system. So far, most research has focused on isolated technical solutions that address only one specific sustainability challenge posed by plastics, such as end-of-life management or feedstock alternatives to fossil fuels. Some interventions might mitigate one problem but contribute to another at a different stage of the plastics life cycle. This study is based on a literature review and adopts qualitative system dynamics to analyse the unsustainability of plastics with a holistic, integrative approach. The paper provides an overview of the impacts of potential solutions on the plastics system, highlighting how some interventions could end up having unintended consequences, perhaps even overshadowing the benefits. 

This DAC stores an ATLAS.ti file containing the analysed documents needed for the study. The corresponding DSC's READ ME file provides more information on the type of data included in this collection and the methodology used to extrapolate data from the literature and build qualitative system dynamics models. Specifically, the DSC includes a list of relevant literature, an explanation of how these documents were coded and the resulting qualitative system dynamics models. The ATLAS.ti file stored in this DAC could not be included in the DSC because it contains the full texts of papers that are not open access.
DOI: 10.34973/brb8-rj67
title: Toegankelijkheid notariële dienstverlening

description: Interviewverslagen van 48 respondenten (notarissen, eerstelijnshulpverleners, schuldhulpverleners, deurwaarders, banken, rechtbank, KNB, rijksvastgoed, kadaster) over de toegankelijkheid van notariële dienstverlening.
DOI: 10.34973/2da2-n598
title: Affective responses to biodiversity loss

description: Qualitative data (transcripts etc. on interviews, focus groups) of studies related to affective responses to biodiversity loss as part of PhD research on the digitally mediated affects of ecological citizen scientists.
DOI: 10.34973/cfvx-0443
title: Co-delivery of antigen and adjuvant by site-specific conjugation to dendritic cell-targeted Fab fragments potentiates T cell responses

description: This data is collected within the context of the doctoral thesis of Zacharias Wijfjes, Chapter 3. It covers the development and testing of a site-specific targeted antigen-adjuvant conjugate.

The work presents a molecularly defined DC-targeted antibody fragment-antigen-adjuvant (AAA) conjugate. The AAA-conjugate is prepared through a combination of CRISPR/HDR hybridoma genome editing, sortase-mediated chemoenzymatic conjugation, and strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry. We successfully generate and characterize the AAA-conjugate and demonstrate unaltered binding capacity due to the cargo being conjugated site-specifically, away from the binding domain of the Fab fragment. Ex vivo, an increase in T cell activation is observed for the AAA-conjugate compared to the antibody fragment-antigen conjugate. We attribute this to a combination of DC maturation induced by the adjuvant and the hydrophobic characteristics of the adjuvant, which seem to enhance cross-presentation. Suboptimal pharmacokinetics hinder in vivo efficacy of the AAA-conjugate, but the data is hinting towards the self-adjuvating capacity of the small fraction of the AAA-conjugate that does reach DCs in vivo. As alternative approach to overcome the suboptimal pharmacokinetics, we present the combination of targeted antigen and targeted adjuvant on separate Fab fragments, which did result in enhanced T cell activation in vivo.
DOI: 10.34973/v4xj-ct33
title: Incidence, Impact and Healthcare-Seeking Behaviour data for Extremity Fractures in resource-limited settings: A Household Survey in Rural Tanzania

description: The household survey was part of a larger line of research, called 'Building Bridges for Broken Bones', in which we explore the current background of extremity fracture management in rural Tanzania, as well as the potential role for intersectoral collaboration between formal healthcare and traditional bonesetters.

This concerns all data generated for the household survey, which was published in World Journal of Surgery under the title "Incidence, Impact and Healthcare-Seeking Behaviour for Extremity Fractures in resource-limited settings: A Household Survey in Rural Tanzania".
It contains the:
- Study protocol 
- The informed consent forms for adults & children, in English & Swahili
- The 3 questionnaires used, in SurveyCTO format
- The raw, pseudonymized data output per questionnaire
- The Rstudio code per questionnaire, used to process and analyze the raw data
DOI: 10.34973/9288-ds63
title: CMyGuideline: Development, validation, and pilot data of a patient-reported instrument for monitoring TKI-related toxicity in real-world CML care

description: This collection contains the data associated with the development, validation and pilot data collection of a patient-reported outcome measure instrument (PROM) for monitoring tyrosine kinase inhibitor (TKI)-related toxicity in chronic myeloid leukemia patients. The data set consists of transcripts of group focus sessions and individual interviews, captured during the qualitative development and validation phases of the new instrument. It also contains longitudinal pilot data captured with the developed patient-reported instrument through online questionnaires, from 278 patients. All text is in Dutch.
DOI: 10.34973/x24g-6388
title: Intracellular bacterial eradication by a colloidal gel

description: This data collection comprises of all data from the thesis of Lizzy Cuypers:

Chapter 2 focused on the fabrication and characterization of HA NPs with an antibacterial ion. After screening 4 different ions on their antibacterial effect and cytocompatibility, zinc was chosen as ion of interest. Therefore ZnHA NPs with varying zinc concentrations (10, 15 and 20 mol%) were fabricated. The particles were characterized in terms of morphology (SEM), size and charge (DLA/ZETA), crystallinity and crystal/molecular structure (XRD, FTIR), zinc release, cytocompatibility and antibacterial effect against Staphylococcus aureus.  

Chapter 3 explored the cytotoxicity and internalization of ZnHA NPs and VGel NPs. First, the morphology (SEM), molecular structure (FTIR) and the size/charge (DLS/ZETA) of the NPs was explored. Then the cytocompatibility and internalization of the NPs by THP-1 derived macrophages. The study validated a co-culture model, comprising THP-1 macrophages and phagocytosed Staphylococcus aureus bacteria,  by stainings and LIVE/DEAD assays. After validating he co-culture, it was used to measure the intracellular antibacterial effect of the NPs.  

Chapter 4 focused on the fabrication and characterization of a colloidal gel comprising of ZnHA and VGel NPs. Various ratios (1:2, 1:1, 2:1) of ZnHA to VGel NPs were assessed for their rheological properties, extracellular antibacterial activity and cytocompatibility. Based on these results, a 1:1 ratio was selected for further investigation of the intracellular antibacterial effect using the co-culture model described in chapter 3. 

Chapter 5 discussed the development of an implant-associated infection model in rats. Initially, a Kirschner wire (K-wire) model, derived from existing literature, was employed. Afterwards, a novel implant design, the screw-wire implant (SW implant), featuring a threaded connection on top that facilitated easier implantation and removal was mentioned. After confirming its biocompatibility, the SW implant was used in combination with Staphylococcus aureus.
DOI: 10.34973/k70k-9y31
title: ARRHYTMHIAS in STRUCTURAL HEART DISEASE

description: The datasets in this repository are pseudonymised patient data with two different datasets: patients with an ASD and arrhymthias and patients with an ICD implantation. In the first the relation en treatmentoptions of atrial arrhytmhias, especially atrial fibrillation is studied and in the second ICD therapy in different subsets of patients is studied and whether clinical risk factors can predict ICD therapy. A substudy was peformed to retrospectively analyze the effect on ICD indication or number of ICD implantation in patients with non-ischemic cardiomyopathy.

The data are collected in SPSS. Original data comes from electronic patient files (EPIC).
The seperate key file is saved on a secured server of the department of cardiology.

No informed consent was provided because of the retrospective nature. 
No permission for sharing data was given.
DOI: 10.34973/yfdw-m947
title: ExerciseEnhances

description: This dataset originates from a pragmatic randomized controlled trial (RCT) titled Sporten Versterkt, conducted between March 2020 and May 2024. The study evaluated the (cost-)effectiveness of structured exercise therapy in addition to treatment-as-usual (TAU) for adults diagnosed with depression. Participants were randomly assigned to either a TAU group or a TAU+exercise intervention group and were followed over time to assess changes in clinical, psychological, and functional outcomes.Data were collected at multiple time points using validated instruments and structured assessments, administered across three mental health care sites in the Netherlands: Radboud University Medical Center, Pro Persona, and GGNet. Variables in the dataset reflect a broad range of measures, including depressive symptomatology (IDS), rumination (RRS), self-esteem (RSES), motivation and energy (MEI), functioning (WHODAS), physical activity (METs and leisure activity), diagnostic status (SCID), and cognitive-emotional bias (Gotlib task). Demographic and treatment-related variables are also included (e.g., age, gender, comorbidity, medication use, therapy attendance, and time-related indicators).This collection is used to store raw data and documentation.
DOI: 10.34973/wp5m-ft38
title: Longitudinal study in myotonic dystrophy type 2 regarding health-related quality of life, pain and fatigue

description: Longitudinal studies in myotonic dystrophy type 2 (DM2) regarding health-related quality of life (HRQoL) are scarce. This lack of information hinders effective patient counseling and management. We established a long-term natural history study to assess the impact of DM2 on various health dimensions, addressing the current scarcity of data on its natural course, with the aim of providing insights that enhance optimal patient care. Over a 13-year period, we examined HRQoL, pain, and fatigue in patients with DM2 in comparison to those with adult-onset DM1.
Between 2006 and 2008, all known patients with DM2 in the Netherlands were invited to complete baseline questionnaires. Age- and sex-matched patients with adult-onset DM1 were approached to participate. These genetically confirmed DM patients were re-approached for follow-up in 2019. Date of birth, sex, weight (kg), height (m) and medication were recorded. The date of death of all deceased patients was recorded. Baseline data of deceased patients or patients who did not consent again were not used.
SF-36 subscales were used to assess the different areas of functional impairment in daily life. All eight SF-36 scales were transformed into scores ranging from 0 to 100, with a lower score indicating worse functioning or more pain.
Pain intensity was assessed by using the McGill Pain Questionnaire (MPQ). Pain intensity was scored from 0 to 100 on a 100 mm horizontal visual analogue scale (VAS), where 0 indicates no pain and 100 the worst imaginable pain.
Fatigue was assessed using the Checklist Individual Strength (CIS-fatigue). Individual items were scored using a 7-point Likert scale, with higher scores indicating higher levels of fatigue. A cut-off score of 76 in the CIS, or a score of 35 or higher on the subjective fatigue subscale indicates severe fatigue.
Baseline characteristics and data on SF-36, MPQ and CIS-fatigue scores were available for analysis with SPSS. Normality of data was tested by the Kolmogorov-Smirnov test. Related-samples Wilcoxon signed-rank test, Mann-Whitney U tests and McNemar tests were applied, as appropriate. As most data was not distributed symmetrically, medians instead of means were used, and the Hodges-Lehmann location-shift estimate of the median group difference with 95% confidence interval was calculated. Spearman correlations were used to measure relationships between patient characteristics and outcome on the questionnaires. P-values below 0.05 were considered to be significant.
DOI: 10.34973/y000-7m31
title: Individualized PeMetRexed dOsing in lung cancER and mesothelioma patients to improVE treatment response and allow treatment of patients with impaired renal function – The IMPROVE study

description: Pemetrexed is a cornerstone in the treatment of lung cancer and mesothelioma. Optimized dosing of pemetrexed based on renal function instead of body surface area (BSA) is hypothesized to reduce pharmacokinetic variability in systemic exposure in patients with adequate renal function and even enable treatment in patients with impaired renal function. The overall goal of the IMPROVE-studies was to investigate individualized, safe dosing of pemetrexed without hampering efficacy.
DOI: 10.34973/4nwh-qr05
title: Lung cancer detection by electronic nose analysis of exhaled breath:  a multi-center prospective external validation study

description: The data was collected in the context of a multi-center prospective external validation study that primarily aimed to (1) prospectively and externally validate the diagnostic performance of a published electronic nose (eNose) model in COPD patients with clinical and/or radiological suspicion of lung cancer at thoracic oncology outpatient clinics, and (2) explore the diagnostic performance of the published and a new eNose model, specifically tailored to the target population, for lung cancer detection in all individuals with clinical and/or radiological suspicion of lung cancer at thoracic oncology outpatient clinics. The secondary aim of the study was to confirm the eNose's discriminatory power with mass spectrometry analysis. The data was collected from two cohorts of adults with clinical and/or radiological suspicion of lung cancer who were referred to the thoracic oncology outpatient clinics of the Radboudumc or the UMCG for further diagnostic evaluation. eNose measurements were performed for both cohorts, while mass spectrometry analysis was only performed for the second cohort. Baseline characteristics and eNose data of both cohorts are included in the files: "Baseline characteristics first cohort" and "Baseline characteristics second cohort". Mass spectrometry data are included in the "TD-GC-MS data second cohort" file.
DOI: 10.34973/hst2-af19
title: Occurrence and predictors of laboratory abnormalities during outpatient parenteral antimicrobial therapy - A multicenter cohort study to inform laboratory test monitoring.

description: Raw data, study protocol, and syntaxes were archived in the Radboud Data Repository. The raw data include data on approx. 1600 OPAT patients, their personal and treatment characteristics and laboratory values.
DOI: 10.34973/p1jd-3d12
title: Preparation, fractionation, and characterization of solubilized elastin peptides and comparison of cellular response on fibroblasts and macrophages

description: This data collection contains research data underlying the results of a scientific research article. Below is a short explanation of the experiments and the content of the collection. Background: Elastin and its derivatives are considered promising biomaterials because of their biological functionality, distinctive natural crosslinking, and capacity to replicate the characteristics of native tissue. Solubilized elastin peptides preserve elastin’s bioactivity and are better suited for wound healing applications than their insoluble counterparts. Goal of the research: We evaluated the differences between various solubilized elastin preparations, with a specific emphasis on their production methods, physicochemical properties, and biological effects on human primary skin fibroblasts and macrophages. These comparisons were intended to enhance our understanding of how different solubilization approaches impact the resulting material's composition and functional behavior.
DOI: 10.34973/t6p9-wb65
title: Het gebruik van uitkomstinformatie in de spreekkamer

description: This study employed a mixed-methods design. Using a grounded theory approach, we interviewed healthcare professionals (HCPs) (n=11) about the use of outcome data in patient consultations. Patients with prostate cancer, lung cancer, and inflammatory bowel disease (IBD) completed questionnaires (n=283) to identify important outcomes. 1. HCPs from the Santeon hospitals were invited for an interview. Santeon is a collaboration of seven non-academic teaching hospitals that collectively strive to improve their care following the principles of value based healthcare. The inclusion criterion was: medical specialists and nurses who were part of a VI team and thus had experience with using outcome data for quality improvement and benchmarking. The exclusion criteria were: 1) HCPs from recently started VI teams with limited experience in outcome data collection and 2) HCPs who participated in the SHOUT study, as their perspectives might be influenced by their role in the study. Interview data is archived at St. Antonius hospital. 2. Patients with one of the following three health conditions, i.e., prostate cancer, lung cancer, and inflammatory bowel disease (IBD), were recruited via Dutch patient organizations and online forums (Crohn & Colitis NL, kanker.nl, Prostaatkanker Stichting, Longkanker NL, foundation DUOS). Patients were asked to rate the importance of aggregated outcomes on a 5-point Likert-scale. They were also asked whether they preferred merely being informed about the outcome or desired a discussion with their HCP about that outcome. The questionnaires incorporated outcomes that were collected by VI teams for quality improvement of the corresponding health condition. To check whether we had reached an inclusive group of patients with regard to health literacy, the three health literacy questions were added to the questionnaire. 
The codebook is added as: codebook vragenlijst patientenvereniging REDCap.pdf
All data is only available in Dutch. All open text data has been removed from the dataset due to privacy restrictions
Data is available from repository upon reasonable request.
DOI: 10.34973/v6xs-a588
title: Current practices and opportunities for outpatient parenteral antimicrobial therapy in hospitals: A national cross-sectional survey

description: Survey among 60 Dutch hospitals about current organization of current organization of OPAT and potential barriers. Raw data, syntax etc included.
DOI: 10.34973/dthp-0748
title: A mixed methods study on the association between burnout symptoms and expectations regarding clerkships in Dutch medical students

description: Background: Over half of the Dutch students experience burnout symptoms. In order to design effective interventions, it is important to know more about cognitions and behaviors that relate to burnout. An example of such cognitions might be inaccurate expectations of medical students regarding their study, as studies in other populations already indicated that unmet expectations can relate to burnout symptoms. Therefore, the aim of this study is to evaluate the relationship between an expectation-reality mismatch of medical students and burnout symptoms. 
Methods: We performed an exploratory mixed methods study consisting of two sequential data collection methods. Firstly, individual semi-structured interviews were performed with six students to explore expectations. Secondly, we designed an anonymous questionnaire to explore presence of expectation mismatches and the relationship with burnout symptoms. Burnout was assessed using the short Burnout Assessment Tool (sBAT).

The data in this folder consist of: 1. The protocol of the semi-structured interviews in English and Dutch 2. The anonymous verbatims of the interviews in English and Dutch 3. The coding of the interviews in English and Dutch  4. The answers to the anonymous questionnaire and the sBAT in English and Dutch 5. Informed consent form. In this new version the coding of the interviews (in English and Dutch) was added to the collection.
DOI: 10.15468/dl.vyhzxb
title: Occurrence Download

description: A dataset containing 20 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Callulops personatus (Zweifel, 1972)"
 ]
}

 The dataset includes 20 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0306721-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.77kbna
title: Occurrence Download

description: A dataset containing 3 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Diprion similis (Hartig, 1834)",
 {
 "not" : {
 "DatasetKey" : [
 "is Global database of alien macrofungi"
 ]
 }
 },
 {
 "or" : [
 "Country is Poland",
 "Country is Poland"
 ]
 }
 ]
}

 The dataset includes 3 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0368666-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.