cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25446/oxford.22892807.v1
title: Patrick Pearse

description: Patrick PearseWriter, educator, republican activist, and Irish language enthusiast. A Gaelic League teacher, Patrick or Pádraig Pearse taught JJ Irish around the turn of the century and, in 1908, founded the bilingual school for boys, St Enda's, modelled on the Belgian educational system. A wide-ranging reader, Pearse adored Shakespeare and revered Ibsen. He was one of the seven signatories of the 1916 Proclamation and served as President of the Provisional Government of the Irish Republic. For his part in the Easter Rising, he was court-martialled and executed by firing squad. He was thirty-six years old at the time of his death. Ronan Crowley
DOI: 10.6084/m9.figshare.14906772.v1
title: Data: Morphological changes in amblyopic eyes

description: Morphological changes in amblyopic eyes
DOI: 10.6084/m9.figshare.21952727.v1
title: Raw data (coordinates)

description: Raw data (coordinates)
DOI: 10.6084/m9.figshare.6823874.v1
title: Additional file 10: of Profiling of testis-specific long noncoding RNAs in mice

description: Table S10. Primers used for qRT-PCR. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8003885.v1
title: Supplementary Material for: Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells

description: Natural direct current electric fields (DC EFs) within tissues undergoing angiogenesis have the potential to influence vessel formation, but how they affect endothelial cells is not clear. We therefore quantified behaviours of human umbilical vein endothelial cells (HUVEC) and human microvasculature endothelial cells (HMEC) stimulated by EFs<i></i>in vitro. Both cell types migrated faster and toward the cathode; HUVECs responded to fields as low as 50mV/mm, but the HMEC threshold was 100 mV/mm. Mitosis was stimulated at 50 mV/mm for HMEC and at 150 mV/mm for HUVECs, but the cleavage plane was oriented orthogonal to the field vector at 200 mV/mm for both cell types. That different field strengths induced different cell responses suggests distinct underlying cellular mechanisms. A physiological electric field also upregulated expression of CXCR4 and CXCR2 chemokine receptors and upregulated phosphorylation of both chemokines in HUVEC and HMEC cells. Evidence that DC EFs direct endothelial cell migration, proliferation and upregulate chemokines involved in wound healing suggests a key role for electrical control of capillary production during healing. Our data contribute to the molecular mechanisms by which DC EFs direct endothelial cell behaviour and present a novel signalling paradigm in wound healing, tissue regeneration and angiogenesis-related diseases.
DOI: 10.6084/m9.figshare.21856557.v1
title: Table S2

description: <em>Full training dataset (Similar to Table S1 but with the addition of phylogenetic and metabolic features).</em>
DOI: 10.6084/m9.figshare.28455068.v1
title: Supplementary File 4 References

description: Psychological interventions for women with polycystic ovary syndrome (PCOS): A systematic review and meta-analysis of randomised and non-randomised controlled trials. References
DOI: 10.6084/m9.figshare.5965852.v1
title: Raw data for fig 1B, S1B and S1C

description: <b>Contents:</b> Combineddata06012014.mat accompanies Fig.1B, S1B and S1C of Sampattavanich et al., Cell Systems (2018). The file contains two variables: <i>reporter</i> and <i>parental</i>, each contains data from 5 timepoints: Each variables contain timepoint struct variables, each with 8x12: Time0: {8×12 cell};Time15: {8×12 cell};Time45: {8×12 cell};Time90: {8×12 cell};Time120: {8×12 cell}.<br>Each cell then contains the following data fields:<br> 'nuc_area' 'nuc_coordX' 'nuc_coordY' 'nuc_formfactor' 'nuc_integratedDAPI' 'nuc_integratedFoxO3' 'nuc_integratedWCDGreen' 'nuc_meanDAPI' 'nuc_meanFoxO3' 'nuc_meanWCDGreen' 'nuc_normmeanFoxO3' 'log10CoverN_extended_norm' 'log10CoverN_extended' 'log10CoverN_4pixel_norm' 'log10CoverN_4pixel' 'extendedcyto_area' 'extendedcyto_integratedDAPI' 'extendedcyto_integratedFoxO3' 'extendedcyto_integratedECDGreen' 'extendedcyto_meanDAPI' 'extendedcyto_meanFoxO3' 'extendedcyto_meanWCDGreen' 'smallcyto_area' 'smallcyto_integratedDAPI' 'smallcyto_integratedFoxO3' 'smallcyto_integratedWCDGreen' 'smallcyto_meanDAPI' 'smallcyto_meanFoxO3' 'smallcyto_meanWCDGreen'<br><b>To use this data with our Git Repository:</b>Placed these in the /rawdata/parentalVSReporter folder.<br> <b>Experimental Setup:</b><br> Treatment Condition: Cells were serum starved for 6 hours, then treated with combination of drugs and ligands for 0, 15, 45, 90, 135 minutes. Parental 184A1 cells were immunostained with FoxO3 antibody. Engineered 184A1 cells with F3aN400 sensor were fixed and directly imaged.<br>
DOI: 10.6084/m9.figshare.21379344.v1
title: Supplementary Material for: MicroRNA-133a-3p inhibits lung adenocarcinoma development and cisplatin resistance through targeting GINS4

description: GINS subunit complex 4 (GINS4) is fundamental to DNA replication and G1/S phase transition of the cell cycle in eukaryotes. Further, recent studies implied that GINS4 can mediate the progression of several tumors, but its mechanism in lung adenocarcinoma (LUAD) is not clarified. Therefore, the role of GINS4 in LUAD was explored. MiR-133a-3p and GINS4 mRNA expression were tested through qRT-PCR. Protein levels of the two genes were assayed by western blot. Their targeting relationship was predicted and verified by bioinformatics prediction and dual-luciferase analysis. The functions of miR-133a-3p and GINS4 in LUAD were evaluated by Transwell, wound healing, CCK8 and flow cytometry assays. MTT assay and caspase-3 activity detection were utilized to measure the regulation of miR-133a-3p/GINS4 in the cisplatin sensitivity of LUAD cells. The results showed that GINS4 was highly expressed in LUAD cells (P&lt;0.05). MiR-133a-3p, which was the upstream gene of GINS4 in LUAD, negatively mediated GINS4 expression. Moreover, overexpressing GINS4 enhanced the proliferative, migratory and invasive abilities of LUAD cells and inhibited cell apoptosis and the sensitivity to cisplatin, while overexpressed miR-133a-3p caused the contrary results. However, the promoting effects of GINS4 overexpression on LUAD could be offset by miR-133a-3p overexpression. MiR-133a-3p could regulate malignant behaviors and cisplatin sensitivity of LUAD cells through negatively regulating GINS4. In conclusion, our findings demonstrated that GINS4 was overexpressed in LUAD and promoted the malignant behavior of LUAD cells. Moreover, miR-133a-3p could negatively regulate GINS4, thereby suppressing the malignant progression and increasing the cisplatin sensitivity of LUAD.
DOI: 10.6084/m9.figshare.5433292.v1
title: Geometric Multiplex Model

description: from "hidden geometric correlations in multiplex networks"
DOI: 10.6084/m9.figshare.5128756.v1
title: Supplementary Material for: Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma

description: <b><i>Background:</i></b> Sirtuin1 (Sirt1) is a member of highly conserved proteins and has been implicated as a tumor promoter as well as a tumor suppressor. One of the mechanisms involves deacetylation of retinoblastoma protein, thereby inhibiting the tumor suppressor function. No study has been reported on the expression of Sirt1 in retinoblastoma. <b><i>Methods:</i></b> We assessed the expression of Sirt1 in sections of archived tissue blocks of enucleated and exenterated specimens of retinoblastoma patients by immunohistochemistry. The histopathological features were reviewed and correlated with the expression of Sirt1. The effect of Sirt1 expression on survival was also assessed. <b><i>Results:</i></b> Retrospective data of 94 patients revealed that the median age at presentation was 36 months, with a male:female ratio of 1.9:1. Fifty-one percent of the patients had International Retinoblastoma Staging System (IRSS) stage 1 disease. Of the 94 sections, 89 (95%) expressed Sirt1. Forty-eight percent of the specimens showed grade 3 staining (&gt;75% of the cells), and the intensity was 3+ in 53%. No association between Sirt1 expression and any histopathological feature was noted. Further, Sirt1 expression did not affect the overall and progression-free survival. <b><i>Conclusions:</i></b> Sirt1 was expressed in most of the retinoblastoma samples. However, the degree of Sirt1 expression was not associated with any high-risk histopathological feature or survival.
DOI: 10.6084/m9.figshare.7963814.v1
title: Interactive community responses to disturbance in streams: disturbance history moderates the influence of disturbance types

description: Data for Eveleens, McIntosh and Warburton 2019 "Interactive community responses to disturbance in streams: disturbance history moderates the influence of disturbance types" testing the relationship between disturbance history and type on aquatic invertebrate community composition using an in-stream channel experiment. This dataset includes invertebrate abundance data for both the communities within the experimental channels and the drift of invertebrates out of channels, measured during disturbance treatments. For this experiment, disturbance treatments included three disturbance types (flooding, drying and a control) applied to individual channels nested within two levels of disturbance history ('stable' and 'frequently disturbed' streams). Full details can be found at http://dx.doi.org/10.1111/oik.05868
DOI: 10.6084/m9.figshare.14157107.v1
title: Validity Test Data of the Solution Chemistr-HOTS-Tawheed Multiple Choice Instrument with Rasch Model

description: This data is the tabulation of answer from 129 respondents to 40 test items of multiple choice on the topic of solution chemistry which develops high-level thingking skills (HOTS) and it's based on tauhid (1 = correct answer; 0 = wrong answer). Further analysis to determine validity using the Rasch Model.<br>
DOI: 10.6084/m9.figshare.27642222.v1
title: Effects of Strength Training on Neuromuscular Adaptations in the Development of Maximal Strength: A Systematic Review and Meta-Analysisd（(Literature screening process and data processing process)

description: These data were generated from the data generated in the above process, screened from different databases and imported into Endnote and Zerto software, and then meta-analyzed by review software
DOI: 10.6084/m9.figshare.7016411.v1
title: Supplementary Material for: tRNA-Derived Fragments as Novel Predictive Biomarkers for Trastuzumab-Resistant Breast Cancer

description: <b><i>Background/Aims:</i></b> Resistance to trastuzumab remains a common challenge to HER-2 positive breast cancer. Up until now, the underlying mechanism of trastuzumab resistance is still unclear. tRNA-derived small non-coding RNAs, a new class of small non-coding RNA (sncRNAs), have been observed to play an important role in cancer progression. However, the relationship between tRNA-derived fragments and trastuzumab resistance is still unknown. <b><i>Methods:</i></b> We detected the levels of tRNA-derived fragments expression in normal breast epithelial cell lines, trastuzumab-sensitive and -resistant breast cancer cell lines using high-throughput sequencing. qRT-PCR was conducted to validate the differentially expressed fragments in serums from trastuzumab-sensitive and -resistant patients. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the power of specific tRNA-derived fragments. Progression-free survival (PFS) was analyzed using Cox-regression. <b><i>Results:</i></b> Our sequence results showed that tRNA-derived fragments were differentially expressed in the HBL-100, SKBR3, and JIMT-1 cell lines. tRF-30-JZOYJE22RR33 and tRF-27-ZDXPHO53KSN were found significantly upregulated in trastuzumab-resistant patients compared to sensitive individuals, and the ROC analysis showed that tRF-30-JZOYJE22RR33 and tRF-27-ZDXPHO53KSN were correlated with trastuzumab resistance. In a multivariate analysis, higher levels of tRF-30-JZOYJE22RR33 and tRF-27-ZDXPHO53KSN expression were associated with significantly shorter PFS in patients with metastatic HER-2 positive breast cancer. <b><i>Conclusion:</i></b> Our results suggest that tRF-30-JZOYJE22RR33 and tRF-27-ZDXPHO53KSN play important roles in trastuzumab resistance. Patients with high levels of tRF-30-JZOYJE22RR33 and tRF-27-ZDXPHO53KSN expression benefitted less from trastuzumab-based therapy than those that express lower-levels of these molecules. tRF-30-JZOYJE22RR33 and tRF-27-ZDXPHO53KSN may be potential biomarkers and intervention targets in the clinical treatment of trastuzumab-resistant breast cancer.
DOI: 10.25451/flinders.16545525.v1
title: Raw un-demultiplexed V4 16s rRNA sequences from I. hirsti ticks collected from six conservation parks (South Australia) between 2005 to 2015

description: Data were collected from 83 ticks across six study sites in South Australia to test if a simple metric of habitat area can predict microbial diversity and prevalence of pathogenic bacterial genera in avian ticks. Ticks were collected opportunistically from birds captured in mist nets. The V4 region of the 16s ribosomal RNA gene of microbes found in the ticks were then sequenced.<br><br>Date coverage: 2005 - 2015<br>Location: South Australia, Australia
DOI: 10.6084/m9.figshare.11890161.v1
title: Radiocarbon dates of sites in North Africa, the Nile Valley and the Levant between 30 and 10 ka

description: This is the supplementary data for:<br><b>P.M. Vermeersch</b>. Human occupation density and mobility in the lower Nile Valley (75,000‑15,000 years ago). <b><i>In </i></b>Leplongeon, A., Goder-Goldberger, M. & Pleurdeau, D.<b> (Eds). </b><i>Not Just a Corridor.</i><b> </b><i>Human occupation of the Nile Valley and neighbouring regions between 75,000 and 15,000 years ago</i>. Natures en Sociétés (3). Muséum national d'Histoire naturelle, Paris, 2020. <b> </b>
DOI: 10.6084/m9.figshare.5286214.v1
title: The Vanderbilt Chest Radiograph Test (VCRT)

description: Images used to test people on AMT - you can use these to reprogram the task using any software you would like.<br>
DOI: 10.6084/m9.figshare.11421573.v1
title: spiR: Client for Social Progress Index Data

description: spiR is an R client to easily access the Social Progress Index database. Published by the Social Progress Imperative, a global non profit based in Washington, DC, the index proposes a new perspective on social challenges and needed efforts to accelerate social progress in line with the Sustainable Development Goals. In this context, the goal of spiR is to allow an easy connection with R to the Social Progress Index in order to benefit from the "power of the crowds".
DOI: 10.15468/dl.mtkrx2
title: Occurrence Download

description: A dataset listing the 15327 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is Australia",
 "DatasetKey is NSW BioNet Atlas",
 {
 "or" : [
 "Geometry POLYGON((104.02334 -44.98425,178.97666 -44.98425,178.97666 -15.01575,104.02334 -15.01575,104.02334 -44.98425))",
 "Geometry POLYGON((151.5999 -33.17862,151.59685 -33.18039,151.59369 -33.1819,151.5917 -33.18351,151.59156 -33.18732,151.59219 -33.19153,151.5932 -33.19353,151.59695 -33.19406,151.5995 -33.19434,151.60131 -33.1956,151.60518 -33.1951,151.60756 -33.19307,151.60953 -33.19055,151.60937 -33.1883,151.6098 -33.18695,151.60906 -33.18369,151.60752 -33.18224,151.60691 -33.18053,151.60672 -33.17858,151.5999 -33.17862))"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 15327 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009470-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.1512817.v2
title: Example of use of CiTO #2

description: Annotating a citation act with an additional text-defined citation function.
DOI: 10.6084/m9.figshare.23723337.v1
title: Supplementary Material for: Efficacy and safety of sucroferric oxyhydroxide compared with sevelamer carbonate in Chinese dialysis patients with hyperphosphataemia: A randomised, open-label, multicentre, 12-week phase III study

description: Introduction: This study aimed to investigate the efficacy and safety of sucroferric oxyhydroxide (SFOH) vs sevelamer carbonate in controlling serum phosphorus (sP) in adult Chinese dialysis patients with hyperphosphataemia (sP &gt;1.78 mmol/L). Methods: Open-label, randomised (1:1), active-controlled, parallel group, multicentre, phase III study of SFOH and sevelamer at starting doses corresponding to 1,500 mg iron/day and 2.4 g/day, respectively, with 8-week dose titration and 4-week maintenance (NCT03644264). Primary endpoint: non-inferiority analysis of change in sP from baseline to Week 12. Secondary endpoints: sP over time and safety. Results: 415 patients screened; 286 enrolled and randomised (142 and 144 to SFOH and sevelamer, respectively). Mean (SD) baseline sP: 2.38 (0.57) and 2.38 (0.52) mmol/L, respectively. Mean (SD) change in sP from baseline to Week 12: –0.71 (0.60) vs –0.63 (0.52) mmol/L, respectively; difference (sevelamer minus SFOH) in least squares means (95% CI): 0.08 mmol/L (–0.02, 0.18) with the lower limit of 95% CI above the non-inferiority margin of –0.34 mmol/L. SFOH group achieved target sP (1.13–1.78 mmol/L) earlier than sevelamer group (56.5% vs 32.8% at Week 4) and with a lower pill burden (mean 3.7 vs 9.1 tablets/day over 4-week maintenance, respectively). Safety and tolerability of SFOH was consistent with previous studies and no new safety signals were observed. Conclusion: SFOH effectively reduced sP from baseline and was non-inferior to sevelamer after 12 weeks of treatment but had a lower pill burden in Chinese dialysis patients with hyperphosphataemia; SFOH benefit–risk profile is favourable in Chinese patients.
DOI: 10.6084/m9.figshare.28358723.v1
title: Global database of environmental microbiomes

description: This is the R object of the Global database of environmental microbiomes. The associated metadata is also available.
DOI: 10.6084/m9.figshare.20466192.v1
title: Dataset

description: Data table of the number of <em>Nemka yasumatsui </em>(Mickel, 1936) females exhibiting tonic immobility.
DOI: 10.6084/m9.figshare.7370657.v1
title: Supplementary Material for: Osteogenic Effect of Inducible Nitric Oxide Synthase (iNOS)-Loaded Mineralized Nanoparticles on Embryonic Stem Cells

description: <b><i>Background/Aims:</i></b> This study investigated the effect of inducible nitric oxide synthase-loaded mineralized nanoparticles (iNOS-MNPs) on the osteogenic differentiation of mouse embryonic stem cells (ESCs). <b><i>Methods:</i></b> We prepared iNOS-MNPs using an anionic block copolymer template-mediated calcium carbonate (CaCO<sub>3</sub>) mineralization process in the presence of iNOS. iNOS-MNPs were spherical and had a narrow size distribution. iNOS was stably loaded within MNPs without denaturation. In order to confirm the successful introduction of iNOS-MNPs into the cytosol of ESCs, intracellular levels of nitric oxide (NO) was determined with a fluorometric analysis. A NO effector molecule, cyclic guanosine 3’,5’ monophosphate (cGMP) was also quantified with a competitive enzyme immunoassay. Cell viability in response to iNOS-MNP treatment was determined using the cell counting kit-8 (CCK-8) assay. Alkaline phosphatase (ALP) activity assay, intracellular calcium quantification assay, and Alizarin red S staining for matrix mineralization were performed to investigate osteogenic differentiation of ESCs. The protein levels of Runt-related transcription factor 2 (RUNX2), osteocalcin (OCN), and osterix (OSX) as osteogenic-related factors were also assessed by immunofluorescence staining and Western blot analysis. The complex pathways associated with iNOS-MNP-derived osteogenic differentiation of ESCs were evaluated by network-based analysis. <b><i>Results:</i></b> Cells with iNOS-MNPs displayed a significant increase in NO and cGMP concentration compared with the control group. When cells were exposed to iNOS-MNPs, there were no adverse effects on cell viability. Importantly, iNOS-MNP uptake promoted the osteogenic differentiation of ESCs. Using transcriptome profiling, we obtained 1,836 differentially-induced genes and performed functional enrichment analysis with ClueGO and KEGG. These analyses identified significantly enriched and interconnected molecular pathways such as protein kinase activity, estrogen receptor activity, bone morphogenetic protein (BMP) receptor binding, ligand-gated ion channel activity, and phosphatidylinositol 3-phosphate binding. <b><i>Conclusion:</i></b> These findings suggest that iNOS-MNPs can induce osteogenic differentiation in ESCs by integrating complex signaling pathways.
DOI: 10.6084/m9.figshare.24580555.v1
title: Supplementary Material for: The association between dapagliflozin use and the risk of post contrast acute kidney injury in patients with type 2 diabetes and chronic kidney disease: a propensity-matched analysis

description: Introduction This study aimed to investigate the effect of dapagliflozin in preventing post contrast acute kidney injury (PC-AKI) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD) who underwent an elective coronary procedure. Methods Data of patients with T2DM and CKD undergoing an elective coronary procedure at Civil Aviation General Hospital from October 2020 to April 2023, were collected from the electronic medical records. Based on dapagliflozin usage, patients were classified as dapagliflozin users and non-users. 1:1 nearest-neighbor propensity matching was performed to compare dapagliflozin users with non-users. The primary endpoint was the first PC-AKI observed. Univariate and multivariate COX regression models were used to determine the independent risk/preventive factors for PC-AKI. Thereafter, subgroup analyses were performed to evaluate the interaction between subgroup and dapagliflozin usage. Changes in the serum creatinine (SCr) and cystatin C (CysC) levels were monitored at 24h, 48h and 72h after the procedure. Results 256 pairs (256 dapagliflozin users in the dapagliflozin group and 256 dapagliflozin non-users in the control group) were identified in the cohort. The incidence of PC-AKI in dapagliflozin group (10.9%) was lower than that in control group (22.3%). COX regression analyses showed that dapagliflozin use was associated with a lower risk of PC-AKI (HR 0.81, 95% CI: 0.69-0.95, P=0.01) after adjustment for covariates. In the subgroup analyses, similar HRs of the dapagliflozin usage on the PC-AKI outcome were observed in patients across different patients’ characteristics which revealed its consistent benefit of preventing PC-AKI. The eGFR levels at post-48h and 72h were significant higher in the dapagliflozin group than those in the control group, while levels of SCr (post-48h and 72h) and CysC (post-24h and 48h) in the dapagliflozin group were lower compared with the control group. Conclusion Our findings suggest dapagliflozin effectively decrease PC-AKI risk and exert reno-protective effects in patients with T2DM and CKD undergoing an elective coronary procedure.