cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12645896
title: Seascape genomics reveals population isolation in the reef-building honeycomb worm, Sabellaria alveolata (L.)

description: Background: Under the threat of climate change populations can disperse, acclimatise or evolve in order to avoid fitness loss. In light of this, it is important to understand neutral gene flow patterns as a measure of dispersal potential, but also adaptive genetic variation as a measure of evolutionary potential. In order to assess genetic variation and how this relates to environment in the honeycomb worm (<i>Sabellaria alveolata </i>(L.)), a reef-building polychaete that supports high biodiversity, we carried out RAD sequencing using individuals from along its complete latitudinal range. Patterns of neutral population genetic structure were compared to larval dispersal as predicted by ocean circulation modelling, and outlier analyses and genotype-environment association tests were used to attempt to identify loci under selection in relation to local temperature data. Results: We genotyped 482 filtered SNPs, from 68 individuals across nine sites, 27 of which were identified as outliers using BAYESCAN and ARLEQUIN. All outlier loci were potentially under balancing selection, despite previous evidence of local adaptation in the system. Limited gene flow was observed among reef-sites (F<sub>ST </sub>= 0.28 ± 0.10), in line with the low dispersal potential identified by the larval dispersal models. The North Atlantic reef emerged as a distinct population and this was linked to high local larval retention and the effect of the North Atlantic Current on dispersal. Conclusions: As an isolated population, with limited potential for natural genetic or demographic augmentation from other reefs, the North Atlantic site warrants conservation attention in order to preserve not only this species, but above all the crucial functional ecological roles that are associated with their bioconstructions. Our study highlights the utility of using seascape genomics to identify populations of conservation concern.
DOI: 10.6084/m9.figshare.12646217.v2
title: Sensor Data Samples for Biovotion Everion, Empatica E4, Bittium Faros 180, Spacelabs (SL 90217) and Tags (From TimeStamp Android App)

description: Example Dataset Containing Samples from:*** SIMULATION OF THE PROTOCOL EXPLAINED IN THE PAPERS BELOW ***<br><br>Empatica E4 (Firmware 2.1.0.4911)https://e4.empatica.com/e4-wristband<br>Biovotion Everion (Firmware 03.06)https://www.biovotion.com/everion/<br>1-lead ECG monitor Faros™180 from Bittium3 (Firmware 3.5.1)https://shop.bittium.com/product/36/bittium-faros-180-solution-pack<br>Spacelabs (SL 90217)https://www.spacelabshealthcare.com/products/diagnostic-cardiology/abp-monitoring/90217a/<br>Tags (obtained with the app: TimeStamp for Android Version 1.36)https://play.google.com/store/apps/details?id=gj.timestamp&hl=en<br>To read this file, please refer to the github page: xxx
DOI: 10.6084/m9.figshare.12645896.v1
title: Seascape genomics reveals population isolation in the reef-building honeycomb worm, Sabellaria alveolata (L.)

description: Background: Under the threat of climate change populations can disperse, acclimatise or evolve in order to avoid fitness loss. In light of this, it is important to understand neutral gene flow patterns as a measure of dispersal potential, but also adaptive genetic variation as a measure of evolutionary potential. In order to assess genetic variation and how this relates to environment in the honeycomb worm (<i>Sabellaria alveolata </i>(L.)), a reef-building polychaete that supports high biodiversity, we carried out RAD sequencing using individuals from along its complete latitudinal range. Patterns of neutral population genetic structure were compared to larval dispersal as predicted by ocean circulation modelling, and outlier analyses and genotype-environment association tests were used to attempt to identify loci under selection in relation to local temperature data. Results: We genotyped 482 filtered SNPs, from 68 individuals across nine sites, 27 of which were identified as outliers using BAYESCAN and ARLEQUIN. All outlier loci were potentially under balancing selection, despite previous evidence of local adaptation in the system. Limited gene flow was observed among reef-sites (F<sub>ST </sub>= 0.28 ± 0.10), in line with the low dispersal potential identified by the larval dispersal models. The North Atlantic reef emerged as a distinct population and this was linked to high local larval retention and the effect of the North Atlantic Current on dispersal. Conclusions: As an isolated population, with limited potential for natural genetic or demographic augmentation from other reefs, the North Atlantic site warrants conservation attention in order to preserve not only this species, but above all the crucial functional ecological roles that are associated with their bioconstructions. Our study highlights the utility of using seascape genomics to identify populations of conservation concern.
DOI: 10.6084/m9.figshare.12645815
title: Supplementary Material for: Anticancer Effects of <b><i>Viscum album</i></b> Fraxini Extract on Medulloblastoma Cells in vitro

description: <b><i>Background:</i></b> Mistletoe therapy is frequently administered as a supportive treatment in diverse pediatric cancer entities including brain tumors. Medulloblastoma is the most common brain tumor in childhood. Its high risk to metastasize and its long-term sequelae caused by aggressive chemo- or radiotherapies are still challenging. <b><i>Material and Methods:</i></b> Effects of a lectin-rich mistletoe extract, abnobaVISCUM Fraxini, were investigated in two medulloblastoma cell lines (Daoy and ONS-76). Responsiveness of tumor cells was assessed by cell viability assays and xCELLigence real-time analyses. Moreover, impacts on proliferation, cell cycle and apoptosis were investigated. Apoptosis was studied by staining of vital mitochondria and assessing the involvement of caspases. In addition, effects on migration and invasion were analyzed. <b><i>Results:</i></b> Both medulloblastoma cell lines were more susceptible to treatment with the mistletoe extract than a nontumorigenic fibroblast cell line. In mistletoe-sensitive Daoy cells, reduction of proliferation and induction of caspase-mediated apoptosis were observed upon administration of 0.05 and 0.5 mg/mL abnobaVISCUM Fraxini treatment, respectively. Furthermore, mistletoe extract inhibited migration and invasion properties in Daoy and significantly impaired invasive capabilities of ONS-76 cells. <b><i>Conclusion:</i></b> AbnobaVISCUM Fraxini has cell line dependent antitumoral effects in medulloblastoma models. These results call for further investigations, to reveal mechanistic insights into antitumorigenic properties of mistletoe extracts.
DOI: 10.6084/m9.figshare.12645815.v1
title: Supplementary Material for: Anticancer Effects of <b><i>Viscum album</i></b> Fraxini Extract on Medulloblastoma Cells in vitro

description: <b><i>Background:</i></b> Mistletoe therapy is frequently administered as a supportive treatment in diverse pediatric cancer entities including brain tumors. Medulloblastoma is the most common brain tumor in childhood. Its high risk to metastasize and its long-term sequelae caused by aggressive chemo- or radiotherapies are still challenging. <b><i>Material and Methods:</i></b> Effects of a lectin-rich mistletoe extract, abnobaVISCUM Fraxini, were investigated in two medulloblastoma cell lines (Daoy and ONS-76). Responsiveness of tumor cells was assessed by cell viability assays and xCELLigence real-time analyses. Moreover, impacts on proliferation, cell cycle and apoptosis were investigated. Apoptosis was studied by staining of vital mitochondria and assessing the involvement of caspases. In addition, effects on migration and invasion were analyzed. <b><i>Results:</i></b> Both medulloblastoma cell lines were more susceptible to treatment with the mistletoe extract than a nontumorigenic fibroblast cell line. In mistletoe-sensitive Daoy cells, reduction of proliferation and induction of caspase-mediated apoptosis were observed upon administration of 0.05 and 0.5 mg/mL abnobaVISCUM Fraxini treatment, respectively. Furthermore, mistletoe extract inhibited migration and invasion properties in Daoy and significantly impaired invasive capabilities of ONS-76 cells. <b><i>Conclusion:</i></b> AbnobaVISCUM Fraxini has cell line dependent antitumoral effects in medulloblastoma models. These results call for further investigations, to reveal mechanistic insights into antitumorigenic properties of mistletoe extracts.
DOI: 10.6084/m9.figshare.12645794
title: Supplementary Material for: A Mixed-Method Study on Strategies in Everyday Personal Goals among Community-Dwelling Older Adults

description: <b><i>Introduction:</i></b> Although it is well known that preference for selection, optimization, and compensation (SOC) strategies is associated with indicators of successful aging and well-being, very little is known about what predicts the use of SOC as goal management strategies in the daily lives of older adults. The present study investigates predictors of self-reported use of SOC strategies in community-dwelling adults. We expected selection and especially compensation to be higher in individuals with worse subjective health and cognitive performance. On the contrary, given that optimization is an anticipatory strategy to increase goal-relevant means in the absence of resource losses, we did not expect optimization to be related to either health or cognition. <b><i>Methods:</i></b> We performed hierarchical regression to predict use of SOC strategies to achieve everyday personal goals (assessed qualitatively via semi-structured interviews exploring participants’ personal goals) from subjective health and objective cognitive performance, controlling for age, apathy, and depression. <b><i>Results:</i></b> Poorer self-rated health and worse cognitive performance positively predicted compensation as a goal management strategy (<i>R</i><sup>2</sup> = 20%), whereas self-rated health just failed to significantly predict selection rates. None of the variables of interest predicted optimization. <b><i>Discussion/Conclusion:</i></b> Whereas previous research suggests associations between reduced resources and decreased absolute frequency of compensation use, the present study found that poorer cognitive status and perceived health are both linked to increased reliance on compensation in order to preserve well-being. In line with their anticipatory nature, the use of optimization strategies was independent from health and cognitive resources in our sample. We discuss the absence of conclusive effects regarding selection in this study in light of the distinction between elective and loss-based selection.
DOI: 10.6084/m9.figshare.12645797
title: Successive peak-flow events

description: These files provide data to reproduce the figures (3-11) for "Effects of successive peak-flow events on hyporheic exchange and residence times" published in Water Resources Research.
DOI: 10.6084/m9.figshare.12645794.v1
title: Supplementary Material for: A Mixed-Method Study on Strategies in Everyday Personal Goals among Community-Dwelling Older Adults

description: <b><i>Introduction:</i></b> Although it is well known that preference for selection, optimization, and compensation (SOC) strategies is associated with indicators of successful aging and well-being, very little is known about what predicts the use of SOC as goal management strategies in the daily lives of older adults. The present study investigates predictors of self-reported use of SOC strategies in community-dwelling adults. We expected selection and especially compensation to be higher in individuals with worse subjective health and cognitive performance. On the contrary, given that optimization is an anticipatory strategy to increase goal-relevant means in the absence of resource losses, we did not expect optimization to be related to either health or cognition. <b><i>Methods:</i></b> We performed hierarchical regression to predict use of SOC strategies to achieve everyday personal goals (assessed qualitatively via semi-structured interviews exploring participants’ personal goals) from subjective health and objective cognitive performance, controlling for age, apathy, and depression. <b><i>Results:</i></b> Poorer self-rated health and worse cognitive performance positively predicted compensation as a goal management strategy (<i>R</i><sup>2</sup> = 20%), whereas self-rated health just failed to significantly predict selection rates. None of the variables of interest predicted optimization. <b><i>Discussion/Conclusion:</i></b> Whereas previous research suggests associations between reduced resources and decreased absolute frequency of compensation use, the present study found that poorer cognitive status and perceived health are both linked to increased reliance on compensation in order to preserve well-being. In line with their anticipatory nature, the use of optimization strategies was independent from health and cognitive resources in our sample. We discuss the absence of conclusive effects regarding selection in this study in light of the distinction between elective and loss-based selection.
DOI: 10.6084/m9.figshare.12645797.v1
title: Successive peak-flow events

description: These files provide data to reproduce the figures (3-11) for "Effects of successive peak-flow events on hyporheic exchange and residence times" published in Water Resources Research.
DOI: 10.6084/m9.figshare.12645791
title: JVASP-17915 to JVASP-18557

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12646217.v4
title: Sensor Data Samples for Biovotion Everion, Empatica E4, Bittium Faros 180, Spacelabs (SL 90217),Tags (From TimeStamp Android App) and Shimmer GSR Plus

description: Example Dataset Containing Samples from:*** SIMULATION OF THE PROTOCOL EXPLAINED IN THE PAPERS BELOW ***<br><br>Empatica E4 (Firmware 2.1.0.4911)https://e4.empatica.com/e4-wristband<br>Biovotion Everion (Firmware 03.06)https://www.biovotion.com/everion/<br>1-lead ECG monitor Faros™180 from Bittium3 (Firmware 3.5.1)https://shop.bittium.com/product/36/bittium-faros-180-solution-pack<br>Spacelabs (SL 90217)https://www.spacelabshealthcare.com/products/diagnostic-cardiology/abp-monitoring/90217a/<br>Tags (obtained with the app: TimeStamp for Android Version 1.36)https://play.google.com/store/apps/details?id=gj.timestamp&hl=en<br>Shimmer GSR Plushttps://www.shimmersensing.com/products/gsr-optical-pulse-development-kit<br><br>To read this file, please refer to the github page: https://github.com/hpi-dhc/devicely
DOI: 10.6084/m9.figshare.12645785
title: JVASP-16474 to JVASP-17309

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645791.v1
title: JVASP-17915 to JVASP-18557

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645785.v1
title: JVASP-16474 to JVASP-17309

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645788
title: JVASP-17310 to JVASP-17914

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645782
title: JVASP-15887 to JVASP-16473

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645788.v1
title: JVASP-17310 to JVASP-17914

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645782.v1
title: JVASP-15887 to JVASP-16473

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12646217.v5
title: Sensor Data Samples for Biovotion Everion, Empatica E4, Bittium Faros 180, Spacelabs (SL 90217),Tags (From TimeStamp Android App) and Shimmer GSR Plus

description: Example Dataset Containing Samples from:*** SIMULATION OF THE PROTOCOL EXPLAINED IN THE PAPERS BELOW ***<br><br>Empatica E4 (Firmware 2.1.0.4911)https://e4.empatica.com/e4-wristband<br>Biovotion Everion (Firmware 03.06)https://www.biovotion.com/everion/<br>1-lead ECG monitor Faros™180 from Bittium3 (Firmware 3.5.1)https://shop.bittium.com/product/36/bittium-faros-180-solution-pack<br>Spacelabs (SL 90217)https://www.spacelabshealthcare.com/products/diagnostic-cardiology/abp-monitoring/90217a/<br>Tags (obtained with the app: TimeStamp for Android Version 1.36)https://play.google.com/store/apps/details?id=gj.timestamp&hl=en<br>Shimmer GSR Plushttps://www.shimmersensing.com/products/gsr-optical-pulse-development-kit<br><br>To read this file, please refer to the github page: https://github.com/hpi-dhc/devicely
DOI: 10.6084/m9.figshare.12645776
title: JVASP-15278 to JVASP-15886

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645743
title: Early Cretaceous glacial environment and paleosurface evolution within the Mount Painter Inlier, northern Flinders Ranges, South Australia

description: LA-ICPMS Geochronology spot data including standards and analytical procedure.
DOI: 10.6084/m9.figshare.12645758
title: Supplementary Material for: Quality of Life during Treatment with Lenvatinib for Thyroid Cancer: The Patients’ Perspective beyond the Medical Evaluation

description: <b><i>Background:</i></b> Lenvatinib (LEN) has shown great efficacy but important toxicity in patients with advanced radioactive iodine-refractory (RAI-R) thyroid cancer (TC); a focused evaluation of its impact on patients’ quality of life (QoL) is still lacking. Our prospective study investigated the impact of this drug on QoL in a group of RAI-R TC patients treated at our centre. <b><i>Methods:</i></b> All patients filled in two questionnaires before and during treatment: (1) the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events adapted questionnaire, assessing prevalence, severity, and/or interference on daily activities of the most frequent symptomatic adverse events (AEs) reported in previous clinical trials during therapy with LEN, and (2) the European Quality of Life 5 Dimensions 3 Levels (EQ-5D-3L) questionnaire, providing the EQ-5D index and the EQ visual analogue scale (EQ-VAS). Data from baseline questionnaires were compared with those obtained 3, 6, and 12 months after the start of treatment. <b><i>Results:</i></b> In our population (<i>n</i> = 20), an overall increased perception of symptomatic AEs emerged during treatment (statistically significant for abdominal pain, asthenia/fatigue, decreased appetite, and xerostomia). The median EQ-5D index and EQ-VAS scores after 3 months of treatment were lower than at baseline, almost returning to initial values after 12 months. <b><i>Conclusion:</i></b> RAI-R TC patients reported a general increase in prevalence and interference on daily activities of symptomatic AEs during therapy with LEN. Self-perceived QoL initially decreased during therapy. However, our data suggest that QoL could be restored after 12 months; this trend might partly reflect the impact of therapy optimisation.
DOI: 10.6084/m9.figshare.12645776.v1
title: JVASP-15278 to JVASP-15886

description: JARVIS-DFT
DOI: 10.6084/m9.figshare.12645770.v1
title: Supplementary Material for: Cardiac Complications during Pregnancy Related to Parity in Women with Congenital Heart Disease

description: <b><i>Objective:</i></b> To describe the frequency of cardiac complications during pregnancy related to parity in women with congenital heart defects. <b><i>Methods:</i></b> A retrospective tertiary single-center study at the Adult Congenital Heart Disease Centre that followed 307 women with congenital heart disease during the years 1997–2015 in Gothenburg, Sweden. Ma­ternal cardiac complications were noted for each pregnancy using medical and obstetric records. The CARPREG I and modified WHO (mWHO) risk classifications were used. Twin pregnancies, miscarriages before gestational week 13, and pregnancy terminations were excluded. <b><i>Results:</i></b> Five hundred seventy-one deliveries and 9 late miscarriages were analyzed. The mean parity was 1.74 per woman (range 1–8). Eighty-four (14.6%) maternal cardiac complications were experienced; arrhythmia (5.7%) and heart failure (4.4%) being the most prevalent, and there was 1 maternal death. Heart failure occurred during the first pregnancy in 12 women (3.9%), in the second pregnancy in 8 women (4.3%), and in the third pregnancy in 4 women (7.7%). CARPREG I and mWHO scores were associated with an increased risk of having a cardiac complication, while parity per se was not associated. The OR for having a maternally uneventful second pregnancy if the first pregnancy was without cardiac complications was 5.47 (95% CI 1.76–16.94) after controlling for CARPREG I and mWHO scores. <b><i>Conclusion:</i></b> The risk of severe maternal cardiac complications during pregnancy in women with congenital heart disease is low. In this largest analysis to date with a focus on parity in 307 women, the risk classification predicts the maternal outcome more than parity per se. If the first pregnancy is uneventful, the OR is 5.5 for an uneventful second pregnancy if CARPREG I and mWHO scores remain unchanged.
DOI: 10.6084/m9.figshare.12645743.v1
title: Early Cretaceous glacial environment and paleosurface evolution within the Mount Painter Inlier, northern Flinders Ranges, South Australia

description: LA-ICPMS Geochronology spot data including standards and analytical procedure.
DOI: 10.6084/m9.figshare.12645713
title: Data for the nonlinear composite Boussinesq equation for estimating baseflow recessions and storage-outflow relationships

description: A nonlinear composite Boussinesq equation for estimating baseflow recessions and storage-outflow relationships
DOI: 10.6084/m9.figshare.12645629
title: Internet data set 2020.sav

description: Internet addiction and attachment in HK
DOI: 10.6084/m9.figshare.12645629.v1
title: Internet data set 2020.sav

description: Internet addiction and attachment in HK
DOI: 10.6084/m9.figshare.12645557
title: graphs.opj

description: This dataset contains molecular dynamics simulation results related to nanohair flagella.
DOI: 10.6084/m9.figshare.12645557.v1
title: graphs.opj

description: This dataset contains molecular dynamics simulation results related to nanohair flagella.
DOI: 10.26181/5f0bca45917c5
title: Population Health data collection for the City of Greater Bendigo

description: This data collection contains de-identified clinical health service utilisation data from Bendigo Health and the General Practitioners Practices associated with the Loddon Mallee Murray Medicare Local. The collection also includes associated population health data from the ABS, AIHW and the Municipal Health Plans. Health researchers have a major interest in how clinical data can be used to monitor population health and health care in rural and regional Australia through analysing a broad range of factors shown to impact the health of different populations. The Population Health data collection provides students, managers, clinicians and researchers the opportunity to use clinical data in the study of population health, including the analysis of health risk factors, disease trends and health care utilisation and outcomes.<br><b>Temporal range (data time period):</b>2004 to 2014<br><b><br></b><b>Spatial coverage:</b>Bendigo Latitude -36.758711200000010000, Bendigo Longitude 144.283745899999990000<br>
DOI: 10.6084/m9.figshare.12645494
title: Adaptive transgenretional effects remain significant

description: This is reanalysis of the data of Yin et al. 2019 Ecol Lett. The data is used in the Reply to the Technical Comment (Sánchez-Tójar et al. 2020, Ecol Lett, The jury is still out regarding the generality of adaptive “transgenerational” effects) on Yin et al. 2019.<pre></pre>