cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.9g89yr
title: Occurrence Download

description: A dataset containing 20632 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is TRUE",
 "HasGeospatialIssue is FALSE",
 "Geometry POLYGON((-100.551 36.917,-71.79 36.917,-71.79 49.612,-100.551 49.612,-100.551 36.917))",
 "Year is greater than or equal to 2024",
 "RecordedBy is one of (evit, Evonne Potts, Evy N, Ezekiel Herrera-Bevan, Ezra Singler, fahminr232, fallriver22, Farland H., farmer6379, farmergirl55, farmgirl117, fart, Fdichfovd, feliciafrass1, fernyguy, fig_leaf, finnwhitmee, Fiona, flanaganapuss, Fluff Berger, flyingember, fortunebones, fotheris, Frances Tackaberry, Frank Lenik, frankvereline8, François Plourde - Renard frak, François Rousseu, Fraser Watson, FreckLes, Fred Watson, fredatwood, fromtheloam, frostfox, Frédérick Létourneau, fullmoonbloom, G P Witteveen, gabbyrobles, gabrialkdingo, Gabriel Andrle, Gabriel Diggs, Gabriel Schneider, gangaa, garethrussell, Garrett Weese, Gary James, Gary S, Gary Zenitsky, gauthier-ambioterra, Gavin Schaefer)",
 "TaxonKey is Plantae"
 ]
}

 The dataset includes 20632 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008847-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18767727
title: Data: Nuclear matter spectral functions

description: The dataset contains single-nucleon spectral functions for infinite nuclear matter obtained using the ADC Green's functions method. The data are saved as a compressed parquet dataset, which can be easily read using the Pandas Python library.
DOI: 10.5281/zenodo.17414063
title: Data: Nuclear matter spectral functions

description: The dataset contains single-nucleon spectral functions for infinite nuclear matter obtained using the ADC Green's functions method. The data are saved as a compressed parquet dataset, which can be easily read using the Pandas Python library.
DOI: 10.15468/tsky5c
title: Fossil freshwater mollusks from the Early Pleistocene (Calabrian) of northern Taiwan

description: This dataset contains the digitized treatments in Plazi based on the original journal article Hsu, Chia-Hsin, Osipova, Diana, Lin, Chien-Hsiang (2025): Fossil freshwater mollusks from the Early Pleistocene (Calabrian) of northern Taiwan. Geodiversitas 47 (20): 721-737, DOI: 10.5252/geodiversitas2025v47a20, URL: https://sciencepress.mnhn.fr/sites/default/files/articles/pdf/geodiversitas2025v47a20.pdfABSTRACTDespite the extensive fossil mollusk records in Taiwan, over 99% are marine species. Among the few freshwater deposits, the Tananwan Formation (1.46-1.24 Ma) in northern Taiwan has been recognized as one of the most prolific fossiliferous strata. In a 1-meter thick fossiliferous mudstone layer within the formation, we identified five molluscan taxa. The assemblage is primarily dominated by Sinotaia quadrata (Benson, 1842) and the less common Melanoides aff. tuberculata, which corresponds to the current freshwater ecosystem in northern Taiwan. This study presents detailed descriptions and images of fossil freshwater molluscan assemblage from Taiwan, providing insights into the origins of contemporary freshwater biodiversity in the subtropical West Pacific. Additionally, in several fossil S. quadrata specimens, juvenile shells were found within female shells, marking the second known case of child-carrying in fossil viviparids.
DOI: 10.6084/m9.figshare.9937946
title: D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina

description: <b>Purpose</b>: The purpose of this study was to investigate the physiological changes of amino acids in the rat retina caused by ocular hypertension. <b>Methods</b>: Adult Wistar rats were used as an experimental model of ocular hypertension. Retinas were hydrolyzed with HCl at 108°C to isolate amino acids. Residual amino acids were measured by reverse-phase high-performance liquid chromatography and the total volume of residual amino acids and the ratio of D- and L-amino acids were analyzed. Free D- and L-alanine levels were also measured using two-dimensional HPLC. <b>Results</b>: The amount of retinal alanine decreased in ocular hypertension compared with the control (<i>p</i> &lt; .05, Student’s <i>t</i>-test); the amounts of other amino acids did not differ between the two conditions. The D/L ratio of alanine was higher than that of other amino acids. Ocular hypertension reduced the D/L ratio of retinal alanine, while that of other amino acids was unchanged. Ocular hypertension increased the D/L ratio of free alanine. <b>Conclusions</b>: Ocular hypertension reduced the D/L ratio of retinal alanine, presumably due in large part to alanine peptides.
DOI: 10.6084/m9.figshare.9937946.v1
title: D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina

description: <b>Purpose</b>: The purpose of this study was to investigate the physiological changes of amino acids in the rat retina caused by ocular hypertension. <b>Methods</b>: Adult Wistar rats were used as an experimental model of ocular hypertension. Retinas were hydrolyzed with HCl at 108°C to isolate amino acids. Residual amino acids were measured by reverse-phase high-performance liquid chromatography and the total volume of residual amino acids and the ratio of D- and L-amino acids were analyzed. Free D- and L-alanine levels were also measured using two-dimensional HPLC. <b>Results</b>: The amount of retinal alanine decreased in ocular hypertension compared with the control (<i>p</i> &lt; .05, Student’s <i>t</i>-test); the amounts of other amino acids did not differ between the two conditions. The D/L ratio of alanine was higher than that of other amino acids. Ocular hypertension reduced the D/L ratio of retinal alanine, while that of other amino acids was unchanged. Ocular hypertension increased the D/L ratio of free alanine. <b>Conclusions</b>: Ocular hypertension reduced the D/L ratio of retinal alanine, presumably due in large part to alanine peptides.
DOI: 10.6084/m9.figshare.9884102
title: Ranibizumab Alters Levels of Intraocular Soluble Cytokine Receptors in Patients with Diabetic Macular Edema

description: <b>Purpose</b>: Ranibizumab, an anti-VEGF-A (vascular endothelial cell growth factor-A) monoclonal antibody fragment, is a well-established treatment for diabetic patients with macular edema. However, very little is known about the effect of ranibizumab on intraocular regulation of pro – and anti-inflammatory signaling pathways and their regulation of VEGF family members, which was the aim of this study. <b>Materials and Methods</b>: Diabetic patients (n = 10) aged ≥18 years with central diabetic macular edema, BCVA &gt;24 and &lt;78, and central macular thickness (CMT) greater than 250 μm were enrolled in this study. Following a full eye exam, imaging, and an aqueous tap, patients received ranibizumab (0.3 mg/0.05 mL) injections at day one and weeks four and eight. At week 12, a full eye exam, imaging, and a second aqueous tap was obtained prior to the last injection of ranibizumab. Pre – and post-treatment aqueous humor samples were then analyzed using Milliplex MAP magnetic bead assays. <b>Results</b>: As expected, ranibizumab lowered levels of VEGF-A, decreased CMT, and improved VA (visual acuity). In addition, it significantly lowered aqueous levels of IL-10, IFNγ, sIL-1R1, sIL-1R2, sRAGE, and VEGF-D. Changes in levels of VEGF-A and VEGF-C strongly correlated with changes in soluble receptors, sgp130 and sIL-6R, associated with IL-6 signaling pathways. In contrast, changes in VEGF-D correlated with sIL-1R1 and sIL-1R2, soluble receptors participating in IL-1 signaling. Changes in CMT and VA did not correlate with changes in levels of VEGF family members. However, post-treatment values of CMT correlated with post-treatment levels of VEGF-C. Post-treatment VA values correlated with a wide variety of potential biomarkers linked to inflammation. <b>Conclusions</b>: Ranibizumab treatment had strong effects on regulating levels of soluble receptors closely linked to IL-1 and IL-6 signaling pathways. Therefore, a complete understanding of the actions of ranibizumab will further the development of additional therapies to support treatment of diabetic macular edema.
DOI: 10.6084/m9.figshare.9884102.v1
title: Ranibizumab Alters Levels of Intraocular Soluble Cytokine Receptors in Patients with Diabetic Macular Edema

description: <b>Purpose</b>: Ranibizumab, an anti-VEGF-A (vascular endothelial cell growth factor-A) monoclonal antibody fragment, is a well-established treatment for diabetic patients with macular edema. However, very little is known about the effect of ranibizumab on intraocular regulation of pro – and anti-inflammatory signaling pathways and their regulation of VEGF family members, which was the aim of this study. <b>Materials and Methods</b>: Diabetic patients (n = 10) aged ≥18 years with central diabetic macular edema, BCVA &gt;24 and &lt;78, and central macular thickness (CMT) greater than 250 μm were enrolled in this study. Following a full eye exam, imaging, and an aqueous tap, patients received ranibizumab (0.3 mg/0.05 mL) injections at day one and weeks four and eight. At week 12, a full eye exam, imaging, and a second aqueous tap was obtained prior to the last injection of ranibizumab. Pre – and post-treatment aqueous humor samples were then analyzed using Milliplex MAP magnetic bead assays. <b>Results</b>: As expected, ranibizumab lowered levels of VEGF-A, decreased CMT, and improved VA (visual acuity). In addition, it significantly lowered aqueous levels of IL-10, IFNγ, sIL-1R1, sIL-1R2, sRAGE, and VEGF-D. Changes in levels of VEGF-A and VEGF-C strongly correlated with changes in soluble receptors, sgp130 and sIL-6R, associated with IL-6 signaling pathways. In contrast, changes in VEGF-D correlated with sIL-1R1 and sIL-1R2, soluble receptors participating in IL-1 signaling. Changes in CMT and VA did not correlate with changes in levels of VEGF family members. However, post-treatment values of CMT correlated with post-treatment levels of VEGF-C. Post-treatment VA values correlated with a wide variety of potential biomarkers linked to inflammation. <b>Conclusions</b>: Ranibizumab treatment had strong effects on regulating levels of soluble receptors closely linked to IL-1 and IL-6 signaling pathways. Therefore, a complete understanding of the actions of ranibizumab will further the development of additional therapies to support treatment of diabetic macular edema.
DOI: 10.6084/m9.figshare.9948563
title: Temporal Regulation of Notch Signaling and Its Influence on the Differentiation of <i>Ex Vivo</i> Cultured Limbal Epithelial Cells

description: <b>Purpose</b>: Notch signaling plays a vital role in the differentiation and proliferation of corneal epithelial cells from limbal stem cells. The temporal regulation of Notch signaling during this differentiation remains unknown. Hence, we investigated the importance of temporal activation/blockage of Notch signaling during corneal differentiation. <b>Methods</b>: Human limbal epithelial cultures were established with and without Notch activators (rec-Human Jagged1 Fc chimera) and pharmacological blockers (LY-411575). The modulation of Notch signaling was done at different time points during cell differentiation, which were collected on Day 14 for further analysis of differentiation, proliferation, maturation and apoptosis using RT-qPCR and immunofluorescence staining. <b>Results</b>: The activation of Notch signaling at Day 8 resulted in the highest number of mature corneal epithelial cells (<i>p</i> = .008) and pro-apoptosis marker BAX (<i>p</i> = .0001) with no increase in the number of corneal progenitors, and proliferation marker Ki67 compared to untreated controls. Cultures grown in the presence of Notch signaling blockers showed a significantly higher number of corneal progenitors (<i>p</i> = .0001) and proliferation marker Ki67 (<i>p</i> = .02) but lower corneal epithelial marker CK3/CK12 (<i>p</i> = .0007) and no difference in the pro-apoptotic marker BAX compared to untreated controls. <b>Conclusion</b>: During the differentiation of limbal epithelial cells to the corneal epithelial cell type, Day 8 seems to be a crucial window to modulate Notch signaling for a customized outcome.
DOI: 10.6084/m9.figshare.9948563.v1
title: Temporal Regulation of Notch Signaling and Its Influence on the Differentiation of <i>Ex Vivo</i> Cultured Limbal Epithelial Cells

description: <b>Purpose</b>: Notch signaling plays a vital role in the differentiation and proliferation of corneal epithelial cells from limbal stem cells. The temporal regulation of Notch signaling during this differentiation remains unknown. Hence, we investigated the importance of temporal activation/blockage of Notch signaling during corneal differentiation. <b>Methods</b>: Human limbal epithelial cultures were established with and without Notch activators (rec-Human Jagged1 Fc chimera) and pharmacological blockers (LY-411575). The modulation of Notch signaling was done at different time points during cell differentiation, which were collected on Day 14 for further analysis of differentiation, proliferation, maturation and apoptosis using RT-qPCR and immunofluorescence staining. <b>Results</b>: The activation of Notch signaling at Day 8 resulted in the highest number of mature corneal epithelial cells (<i>p</i> = .008) and pro-apoptosis marker BAX (<i>p</i> = .0001) with no increase in the number of corneal progenitors, and proliferation marker Ki67 compared to untreated controls. Cultures grown in the presence of Notch signaling blockers showed a significantly higher number of corneal progenitors (<i>p</i> = .0001) and proliferation marker Ki67 (<i>p</i> = .02) but lower corneal epithelial marker CK3/CK12 (<i>p</i> = .0007) and no difference in the pro-apoptotic marker BAX compared to untreated controls. <b>Conclusion</b>: During the differentiation of limbal epithelial cells to the corneal epithelial cell type, Day 8 seems to be a crucial window to modulate Notch signaling for a customized outcome.
DOI: 10.48580/dgv8h.v9
title: Fossil freshwater mollusks from the Early Pleistocene (Calabrian) of northern Taiwan
DOI: 10.6084/m9.figshare.9981389
title: A Novel Mutation p.S93R in CRYBB1 Associated with Dominant Congenital Cataract and Microphthalmia

description: <b>Purpose</b>: To identify the pathogenetic mutations in a four-generation Chinese family with dominant congenital cataracts and microphthalmia. <b>Methods</b>: A four-generation Chinese family with dominant congenital cataracts were recruited. Genomic DNAs were collected from their peripheral blood leukocytes and subjected to whole exome sequencing. The genetic mutations were identified by bioinformatic analyses and verified by Sanger sequencing. <b>Results</b>: Whole exome sequencing revealed a c.279C&gt;G point mutation in the <i>CRYBB1</i> gene which was further verified by Sanger sequencing. The nucleotide replacement results in a novel mutation p.S93R in a conserved residue of βB1 crystallin which is predicted to disrupt normal βB1 structure and function. <b>Conclusions</b>: We identified a novel missense mutation p.S93R in CRYBB1 in a Chinese family with autosomal dominant congenital cataracts and microphthalmia. This serine residue is extremely conserved evolutionarily in more than 50 βγ-crystallins of many species. These data will be very helpful to further understand the structural and functional features of crystallins.
DOI: 10.6084/m9.figshare.9981389.v1
title: A Novel Mutation p.S93R in CRYBB1 Associated with Dominant Congenital Cataract and Microphthalmia

description: <b>Purpose</b>: To identify the pathogenetic mutations in a four-generation Chinese family with dominant congenital cataracts and microphthalmia. <b>Methods</b>: A four-generation Chinese family with dominant congenital cataracts were recruited. Genomic DNAs were collected from their peripheral blood leukocytes and subjected to whole exome sequencing. The genetic mutations were identified by bioinformatic analyses and verified by Sanger sequencing. <b>Results</b>: Whole exome sequencing revealed a c.279C&gt;G point mutation in the <i>CRYBB1</i> gene which was further verified by Sanger sequencing. The nucleotide replacement results in a novel mutation p.S93R in a conserved residue of βB1 crystallin which is predicted to disrupt normal βB1 structure and function. <b>Conclusions</b>: We identified a novel missense mutation p.S93R in CRYBB1 in a Chinese family with autosomal dominant congenital cataracts and microphthalmia. This serine residue is extremely conserved evolutionarily in more than 50 βγ-crystallins of many species. These data will be very helpful to further understand the structural and functional features of crystallins.
DOI: 10.15468/dl.6k63e4
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Morocco",
 "TaxonKey is Salsola webbii"
 ]
}

 The dataset includes 31 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009202-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g7tb7t
title: Occurrence Download

description: A dataset containing 669 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "NetworkKey is 99d66b6c-9087-452f-a9d4-f15f2c2d0e7e",
 "TaxonKey is Chordata"
 ]
 },
 {
 "and" : [
 "InstitutionCode is one of (AMNH)",
 "TaxonKey is one of (Chilabothrus [GBIF Backbone Taxonomy], Epicrates [GBIF Backbone Taxonomy], Eunectes [GBIF Backbone Taxonomy], Sanzinia [GBIF Backbone Taxonomy], Acrantophis [GBIF Backbone Taxonomy], Corallus [GBIF Backbone Taxonomy], Boa [GBIF Backbone Taxonomy])"
 ]
 }
 ]
}

 The dataset includes 669 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009203-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18767729
title: PEDAGOGICAL FACTORS IN DEVELOPING ANALYTICAL THINKING SKILLS

description: This study examines the pedagogical factors that influence the development of analytical thinking skills in students. It considers curriculum content, teaching methods, teacher and student engagement, and the role of the educational environment. The results show that these factors enhance students’ ability to analyze problems and draw logical conclusions. The study emphasizes the importance of fostering critical thinking and creative approaches in the educational process.
DOI: 10.5281/zenodo.18767728
title: PEDAGOGICAL FACTORS IN DEVELOPING ANALYTICAL THINKING SKILLS

description: This study examines the pedagogical factors that influence the development of analytical thinking skills in students. It considers curriculum content, teaching methods, teacher and student engagement, and the role of the educational environment. The results show that these factors enhance students’ ability to analyze problems and draw logical conclusions. The study emphasizes the importance of fostering critical thinking and creative approaches in the educational process.
DOI: 10.6084/m9.figshare.30103996
title: ControlCity-Model

description: Model checkpoints of ControlCity
DOI: 10.6084/m9.figshare.30103996.v1
title: ControlCity-Model

description: Model checkpoints of ControlCity
DOI: 10.15468/dl.rducaw
title: Occurrence Download

description: A dataset containing 13816 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Spheniscus humboldti",
 "Year 2000-2026"
 ]
}

 The dataset includes 13816 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009206-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.85zmzs
title: Occurrence Download

description: A dataset containing 1866 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Specimen)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Lilium humboldtii",
 "Year 2000-2026"
 ]
}

 The dataset includes 1866 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009207-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bmxvqe
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Continent is Asia",
 "Country is Indonesia",
 "Geometry POLYGON((103.47404 -7.25443,115.09127 -9.17069,113.80047 -6.10061,107.54007 -4.36535,103.47404 -7.25443))",
 "HasGeospatialIssue is false",
 "TaxonKey is Nycticebus javanicus",
 "Year 2000-2020"
 ]
}

 The dataset includes 18 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009205-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vnhbmn
title: Occurrence Download

description: A dataset containing 13134 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON((22.38535 -28.66494,22.58099 -28.66494,22.58099 -28.44684,22.38535 -28.44684,22.38535 -28.66494))"
 ]
}

 The dataset includes 13134 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009208-260221153910048/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.