cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21516303
title: Factor analysis of the performance at the medical residency exam, progress test and clerkship rotations performance coefficient

description: Abstract: Introduction: The relationships between the students’ performance on medical residency exams and progress tests and medical clerkship rotations are not well established. Objective: The objective of this study was to measure the correlations between grades on progress tests and clerkship rotations assessments and the medical residency exam and determine which performance had the strongest correlation with the final medical residency exam. Methods: This was a retrospective and longitudinal study with correlation analyses of grades on progress tests from the 1st to 6th year of medical school, the clerkship rotations performance coefficient (5th and 6th years of school) and the final medical residency exam in a cohort of students enrolled in a federal public medical school using factor analysis. Students who performed the progress tests from the 1st to 6th year were included. Results: Of 123 students enrolled in the first year of medical school in 2009, 114 (92.7%) performed the progress tests during the six years and were included. The average grades on the progress tests from 1 to 10 were 2.67 (1st year), 3.01 (2nd year), 4.19 (3rd year), 4.01 (4th year), 5.19 (5th year), and 6.38 (6th year). The average grades in the clerkship rotations were 8.32 (5th year) and 8.26 (6th year). The average score on the theoretical medical residency exam was 7.53 and the final result of the medical residency exam was 8.05. Factor analysis detected three domains with greater correlation strength that accounted for 76.3% of the model variance. Component 1 was identified as the coefficient of academic performance (CAP) 5th, CAP 6th and final medical residency exam grades, whereas component 2 was constituted by the grades of the 5th and 6th years progress tests and the third component comprised the progress tests of the 2nd, 3rd and 4th years. Conclusions: Grades on the progress tests, the clerkship rotations assessments and the final medical residency exam were correlated. Moreover, the performance during the medical clerkship rotations showed the strongest correlations with medical residency exam grades.
DOI: 10.6084/m9.figshare.21516303.v1
title: Factor analysis of the performance at the medical residency exam, progress test and clerkship rotations performance coefficient

description: Abstract: Introduction: The relationships between the students’ performance on medical residency exams and progress tests and medical clerkship rotations are not well established. Objective: The objective of this study was to measure the correlations between grades on progress tests and clerkship rotations assessments and the medical residency exam and determine which performance had the strongest correlation with the final medical residency exam. Methods: This was a retrospective and longitudinal study with correlation analyses of grades on progress tests from the 1st to 6th year of medical school, the clerkship rotations performance coefficient (5th and 6th years of school) and the final medical residency exam in a cohort of students enrolled in a federal public medical school using factor analysis. Students who performed the progress tests from the 1st to 6th year were included. Results: Of 123 students enrolled in the first year of medical school in 2009, 114 (92.7%) performed the progress tests during the six years and were included. The average grades on the progress tests from 1 to 10 were 2.67 (1st year), 3.01 (2nd year), 4.19 (3rd year), 4.01 (4th year), 5.19 (5th year), and 6.38 (6th year). The average grades in the clerkship rotations were 8.32 (5th year) and 8.26 (6th year). The average score on the theoretical medical residency exam was 7.53 and the final result of the medical residency exam was 8.05. Factor analysis detected three domains with greater correlation strength that accounted for 76.3% of the model variance. Component 1 was identified as the coefficient of academic performance (CAP) 5th, CAP 6th and final medical residency exam grades, whereas component 2 was constituted by the grades of the 5th and 6th years progress tests and the third component comprised the progress tests of the 2nd, 3rd and 4th years. Conclusions: Grades on the progress tests, the clerkship rotations assessments and the final medical residency exam were correlated. Moreover, the performance during the medical clerkship rotations showed the strongest correlations with medical residency exam grades.
DOI: 10.6084/m9.figshare.21516306
title: Two accelerated isogeometric boundary element method formulations: fast multipole method and hierarchical matrices method

description: Abstract This work presents two fast isogeometric formulations of the Boundary Element Method (BEM) applied to heat conduction problems, one accelerated by Fast Multipole Method (FMM) and other by Hierarchical Matrices. The Fast Multipole Method uses complex variables and expansion of fundamental solutions into Laurant series, while the Hierarchical Matrices are created by low rank CUR approximations from the k−Means clustering technique for geometric sampling. Both use Non-Uniform Rational B-Splines (NURBS) as shape functions. To reduce computational cost and facilitate implementation, NURBS are decomposed into Bézier curves, making the isogeometric formulation very similar to the conventional BEM. A description of the hierarchical structure of the data and the implemented algorithms are presented. Validation is performed by comparing the results of the proposed formulations with those of the conventional BEM formulation. The computational cost of both formulations is analyzed showing the advantages of the proposed formulations for large scale problems.
DOI: 10.6084/m9.figshare.21516306.v1
title: Two accelerated isogeometric boundary element method formulations: fast multipole method and hierarchical matrices method

description: Abstract This work presents two fast isogeometric formulations of the Boundary Element Method (BEM) applied to heat conduction problems, one accelerated by Fast Multipole Method (FMM) and other by Hierarchical Matrices. The Fast Multipole Method uses complex variables and expansion of fundamental solutions into Laurant series, while the Hierarchical Matrices are created by low rank CUR approximations from the k−Means clustering technique for geometric sampling. Both use Non-Uniform Rational B-Splines (NURBS) as shape functions. To reduce computational cost and facilitate implementation, NURBS are decomposed into Bézier curves, making the isogeometric formulation very similar to the conventional BEM. A description of the hierarchical structure of the data and the implemented algorithms are presented. Validation is performed by comparing the results of the proposed formulations with those of the conventional BEM formulation. The computational cost of both formulations is analyzed showing the advantages of the proposed formulations for large scale problems.
DOI: 10.5281/zenodo.6772857
title: Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

description: Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in both wild-type and genetic epilepsy model rats were markedly augmented in response to the prolonged inhibition of CaMKII, indicating that the inactivation of CaMKII enhanced the neuronal excitability. Electrophysiological recording showed that CaMKII inhibition induced hyperexcitability of cultured hippocampal neurons and potentiation of neuronal activity in induced pluripotent stem cell (iPSC)-derived cortical neurons. We further revealed that CaMKII inhibition enhanced the persistent slow inactivating sodium current (I<sub>NaP</sub>) of hippocampal neurons, which was attributed to increased neuronal expression of the voltage-gated sodium channel Na<sub>V</sub>1.2. Our findings suggest that Na<sub>V</sub>1.2 expression was transcriptionally upregulated by the negative regulator nuclear receptor subfamily 4 group A member 2 (<em>NR4A2</em>). Furthermore, CaMKII inhibition induced interaction between Na<sub>V</sub>1.2 and CaM through immunoprecipitation assay. Intriguingly, a peptide that antagonized the binding of CaM to the IQ domain of Na<sub>V</sub>1.2 prevented neuronal hyperexcitability induced by CaMKII inhibition <em>in vivo</em> and <em>in vitro</em>. Altogether, we unveil that prolonged CaMKII inhibition leads to hyperexcitability through increasing the expression of Na<sub>V</sub>1.2 and its association with CaM. Thus, our study uncovers a novel signaling mechanism by which CaMKII maintains to appropriate neuronal excitability.
DOI: 10.6084/m9.figshare.21516308
title: Family quality of life: an integrative review on the family of people with disabilities

description: Abstract The objective of this integrative revision is to understand the Brazilian scientific production of the thematic focus on the family quality of life (FQoL) of people with disabilities, as well as the participating population, referential theory, and instruments used in the studies. The data survey was done in the BVS, Scielo, and PubMed databases, and in the Capes’ Periodic portal, whose inclusion criteria were articles published from 2007 to 2018, available fully online, in Portuguese or English. These articles portrayed the theme of life quality of families of people with disabilities and articles from research done in Brazilian contexts. The results showed that only three of the 19 selected articles to the study analyzed the theme of FQoL directly including the aspects related to the construct. They also pointed out that WHOQOL-Bref was the most used instrument to evaluate the FQoL (n=11), followed by semi structured interviews (n=5) and that only 10,5%, i.e., two articles used the appropriated definition of the FQoL. The research determined that the thematic research is still in the beginning stage in the scientific national production, large use of individual constructs of life quality, and sparse presence of specific measures instruments to measure FQoL.
DOI: 10.6084/m9.figshare.21516308.v1
title: Family quality of life: an integrative review on the family of people with disabilities

description: Abstract The objective of this integrative revision is to understand the Brazilian scientific production of the thematic focus on the family quality of life (FQoL) of people with disabilities, as well as the participating population, referential theory, and instruments used in the studies. The data survey was done in the BVS, Scielo, and PubMed databases, and in the Capes’ Periodic portal, whose inclusion criteria were articles published from 2007 to 2018, available fully online, in Portuguese or English. These articles portrayed the theme of life quality of families of people with disabilities and articles from research done in Brazilian contexts. The results showed that only three of the 19 selected articles to the study analyzed the theme of FQoL directly including the aspects related to the construct. They also pointed out that WHOQOL-Bref was the most used instrument to evaluate the FQoL (n=11), followed by semi structured interviews (n=5) and that only 10,5%, i.e., two articles used the appropriated definition of the FQoL. The research determined that the thematic research is still in the beginning stage in the scientific national production, large use of individual constructs of life quality, and sparse presence of specific measures instruments to measure FQoL.
DOI: 10.6084/m9.figshare.21516311
title: Medical rationalities: evaluation of optional component in medical training

description: Abstract: Introduction: Overcoming the global crisis of the biomedical paradigm has promoted the insertion of Traditional Medicine in public health systems in many countries. Brazil is at the forefront of this movement, and since the launch of the National Policy on Integrative and Complementary Practices in 2006, it has officially included practices in the health care offered by the SUS. However, low qualification in this area of the professionals who work for the SUS, has hindered the levels of resolution in these services. One of the major challenges is training professionals who would be sensitive to health practices from other cultures and follow a vitalist paradigm. The study hypothesis is that the inclusion of socio-historical-epistemological content of Medical Rationalities during professional training can introduce an effective articulation between different medicines, promoting integrated knowledge. Objective: To assess the interest of academics in the topic, which carries little recognition in medical courses in Brazil but has been increasingly valued and incorporated into medical education in many countries. Method: This is a mixed-approach study. The qualitative analysis was organized by exploring the data collected with open-ended questions applied to students on the first day of classes and at the end of the course. The cross-sectional analysis was performed using information collected in a closed questionnaire applied to students. Result: Considering the questions presented to students at the beginning and the end of the component, expectations were exceeded, with very high assessment levels achieved at the end. The study participants showed interest in new knowledge in the training period. The analyses allow us to assert that including this theme sharpens critical reflection on the paradigms, even though it is presented vertically, punctually, and with an informative character, in the context of the course. There was great interest from participants in disciplines that addressed this scientific field. Conclusion: There are good prospects for the integration and complementarity of new knowledge and health practices in medical education in the reality of the studied course.
DOI: 10.6084/m9.figshare.21516311.v1
title: Medical rationalities: evaluation of optional component in medical training

description: Abstract: Introduction: Overcoming the global crisis of the biomedical paradigm has promoted the insertion of Traditional Medicine in public health systems in many countries. Brazil is at the forefront of this movement, and since the launch of the National Policy on Integrative and Complementary Practices in 2006, it has officially included practices in the health care offered by the SUS. However, low qualification in this area of the professionals who work for the SUS, has hindered the levels of resolution in these services. One of the major challenges is training professionals who would be sensitive to health practices from other cultures and follow a vitalist paradigm. The study hypothesis is that the inclusion of socio-historical-epistemological content of Medical Rationalities during professional training can introduce an effective articulation between different medicines, promoting integrated knowledge. Objective: To assess the interest of academics in the topic, which carries little recognition in medical courses in Brazil but has been increasingly valued and incorporated into medical education in many countries. Method: This is a mixed-approach study. The qualitative analysis was organized by exploring the data collected with open-ended questions applied to students on the first day of classes and at the end of the course. The cross-sectional analysis was performed using information collected in a closed questionnaire applied to students. Result: Considering the questions presented to students at the beginning and the end of the component, expectations were exceeded, with very high assessment levels achieved at the end. The study participants showed interest in new knowledge in the training period. The analyses allow us to assert that including this theme sharpens critical reflection on the paradigms, even though it is presented vertically, punctually, and with an informative character, in the context of the course. There was great interest from participants in disciplines that addressed this scientific field. Conclusion: There are good prospects for the integration and complementarity of new knowledge and health practices in medical education in the reality of the studied course.
DOI: 10.6084/m9.figshare.21516312
title: Does the functional leaf anatomy of Justicia calycina (Acanthaceae) reflect variation across a canopy gradient in the Southern Brazilian Amazon?

description: ABSTRACT Justicia calycina is a subshrub well distributed in northern South America. Despite its widespread occurrence, little is known about its anatomy and plasticity in different environments. Our study aimed to evaluate how leaf anatomical traits of J. calycina adjust in forest areas with variations in canopy openness in the Southern Amazon, Mato Grosso State, Brazil. Forest areas were: Open and Dense Ombrophilous Forest, and Seasonal Deciduous Forest (rocky outcrop). We performed anatomical measurements in leaves sampled on 10 individuals in each forest site, with the help of usual anatomy techniques. Foliar anatomy of J. calycina showed similar pattern among the studied forests, with significant difference (p&lt;0.05) in four leaf traits among 22 studied: vascular bundle diameter, palisade parenchyma thickness, stomatal density and trichome density in adaxial epidermis. These leaf traits showed high plasticity index, with higher values in Dense Forest and in Deciduous Forest. Even though J. calycina showed overall little anatomical variation among forest types, the few attributes that differed are fundamental in the photosynthesis process. The adjustment in leaf anatomical traits under different luminosity conditions demonstrates a degree of phenotypic plasticity in the species, which contributes to its distribution in different forest phytophysiognomies in Brazilian Amazonia.
DOI: 10.6084/m9.figshare.21516312.v1
title: Does the functional leaf anatomy of Justicia calycina (Acanthaceae) reflect variation across a canopy gradient in the Southern Brazilian Amazon?

description: ABSTRACT Justicia calycina is a subshrub well distributed in northern South America. Despite its widespread occurrence, little is known about its anatomy and plasticity in different environments. Our study aimed to evaluate how leaf anatomical traits of J. calycina adjust in forest areas with variations in canopy openness in the Southern Amazon, Mato Grosso State, Brazil. Forest areas were: Open and Dense Ombrophilous Forest, and Seasonal Deciduous Forest (rocky outcrop). We performed anatomical measurements in leaves sampled on 10 individuals in each forest site, with the help of usual anatomy techniques. Foliar anatomy of J. calycina showed similar pattern among the studied forests, with significant difference (p&lt;0.05) in four leaf traits among 22 studied: vascular bundle diameter, palisade parenchyma thickness, stomatal density and trichome density in adaxial epidermis. These leaf traits showed high plasticity index, with higher values in Dense Forest and in Deciduous Forest. Even though J. calycina showed overall little anatomical variation among forest types, the few attributes that differed are fundamental in the photosynthesis process. The adjustment in leaf anatomical traits under different luminosity conditions demonstrates a degree of phenotypic plasticity in the species, which contributes to its distribution in different forest phytophysiognomies in Brazilian Amazonia.
DOI: 10.6084/m9.figshare.21516314
title: Organizational Justice - An Overview of the Brazilian Scientific Production

description: Abstract The relevance of organizational justice for the improvement of the relationship between workers and organizations has given the theme a prominent role on the international stage in recent decades. In Brazil, discrepancies between national and foreign contributions were pointed out by the last review on the subject, in 2005. Thus, this study analyzed the Brazilian scientific production on organizational justice, focusing on the dimensions of the organizational justice, the theoretical background, and the relationships investigated. A semi-systematic literature review was carried out in 19 journals (1996-2018). The results showed significant differences between national and international production. A national research agenda is presented, highlighting the need for studies exploring the antecedents and the effects of the process of mediation and interaction of justice and a better theoretical foundation.
DOI: 10.6084/m9.figshare.21516314.v1
title: Organizational Justice - An Overview of the Brazilian Scientific Production

description: Abstract The relevance of organizational justice for the improvement of the relationship between workers and organizations has given the theme a prominent role on the international stage in recent decades. In Brazil, discrepancies between national and foreign contributions were pointed out by the last review on the subject, in 2005. Thus, this study analyzed the Brazilian scientific production on organizational justice, focusing on the dimensions of the organizational justice, the theoretical background, and the relationships investigated. A semi-systematic literature review was carried out in 19 journals (1996-2018). The results showed significant differences between national and international production. A national research agenda is presented, highlighting the need for studies exploring the antecedents and the effects of the process of mediation and interaction of justice and a better theoretical foundation.
DOI: 10.6084/m9.figshare.21516317
title: Linear and nonlinear models to describe the lactation curve of Girolando cows

description: Abstract The objective of this work was to compare the main linear and nonlinear models used to describe lactation curves and to evaluate the nonlinearity of the nonlinear models, in order to obtain the most adequate model to describe the lactation curves of the Girolando breed. Data from 165 lactations of 89 3/4 Holstein + 1/4 Gyr cows were used, and average yield was calculated every 20 days up to 310 days of lactation. Seventeen models of lactation curves available in the literature were compared. The selection of the best model was based on the curvature measures of Bates & Watts, the bias of Box, adjusted coefficient of determination, Akaike’s information criterion, and residual standard deviation. The linear model of Cobuci estimated a yield peak of 16.7 kg at 40 days of lactation, whereas the nonlinear model of Wood estimated a yield peak of 16.8 kg at 41 days of lactation and a persistence of 6.82. Nonlinearity measures were the most appropriate for selecting the most suitable nonlinear model for the description of lactation curves. To describe the lactation curves of the Girolando breed, the most suitable linear model is that of Cobuci and the nonlinear model is that of Wood.