cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.13290731
title: Additional file 4 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 4: Table S3A-D. Associations between DNA methylation levels and overweight/obesity versus normal weight. Results for CpGs with p-values &lt; 1x10-4 are shown.
DOI: 10.6084/m9.figshare.21164357
title: Efficacy and safety of neoadjuvant therapy for triple-negative breast cancer: a Bayesian network meta-analysis

description: Numerous studies have concentrated on neoadjuvant therapies for treating triple-negative breast cancer (TNBC) that improve the pathological complete response (pCR) rate but remain controversial. We conducted a network meta-analysis (NMA) to objectively explore the efficacy and safety of different neoadjuvant regimens. Phase II/III randomized clinical trials that compared different neoadjuvant therapies for TNBC were included. NMA and pairwise meta-analysis were performed using WinBUGS (version 1.4.3) and Review Manager 5.3. Forty-four studies with 8459 patients met the eligibility criteria. The NMA of pCR showed that programmed cell death Protein-1 and programmed cell death Ligand-1 inhibitors (PD-1/PD-L1), bevacizumab (Bev), zoledronic acid (ZOL), and platinum salts plus poly polymerase inhibitors (Pt+PARPi) may be favorable for TNBC neoadjuvant therapy. Chemotherapy combined with platinum salts or nanoparticle albumin-bound paclitaxel (Nab-p) has additional beneficial effects. However, neo-type drugs may also have increased toxicity. PD-1/PD-L1, Bev, ZOL, and Pt+ PARPi-containing regimens improved the pCR rate compared to traditional chemotherapy, including anthracyclines and taxanes. Chemotherapy with platinum salts or Nab-p improved the pCR rate. Nevertheless, the balance between efficacy and toxicity should be evaluated rigorously. PD-1/PD-L1-containing regimens appear to be the most favorable for TNBC neoadjuvant therapy, with good efficacy and tolerance.
DOI: 10.6084/m9.figshare.21164357.v1
title: Efficacy and safety of neoadjuvant therapy for triple-negative breast cancer: a Bayesian network meta-analysis

description: Numerous studies have concentrated on neoadjuvant therapies for treating triple-negative breast cancer (TNBC) that improve the pathological complete response (pCR) rate but remain controversial. We conducted a network meta-analysis (NMA) to objectively explore the efficacy and safety of different neoadjuvant regimens. Phase II/III randomized clinical trials that compared different neoadjuvant therapies for TNBC were included. NMA and pairwise meta-analysis were performed using WinBUGS (version 1.4.3) and Review Manager 5.3. Forty-four studies with 8459 patients met the eligibility criteria. The NMA of pCR showed that programmed cell death Protein-1 and programmed cell death Ligand-1 inhibitors (PD-1/PD-L1), bevacizumab (Bev), zoledronic acid (ZOL), and platinum salts plus poly polymerase inhibitors (Pt+PARPi) may be favorable for TNBC neoadjuvant therapy. Chemotherapy combined with platinum salts or nanoparticle albumin-bound paclitaxel (Nab-p) has additional beneficial effects. However, neo-type drugs may also have increased toxicity. PD-1/PD-L1, Bev, ZOL, and Pt+ PARPi-containing regimens improved the pCR rate compared to traditional chemotherapy, including anthracyclines and taxanes. Chemotherapy with platinum salts or Nab-p improved the pCR rate. Nevertheless, the balance between efficacy and toxicity should be evaluated rigorously. PD-1/PD-L1-containing regimens appear to be the most favorable for TNBC neoadjuvant therapy, with good efficacy and tolerance.
DOI: 10.6084/m9.figshare.13290728
title: Additional file 3 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 3: Table S2A-D. Associations between DNA methylation and BMI in the main meta-analyses. Results for CpGs with p-values &lt; 1x10-4 are shown.
DOI: 10.6084/m9.figshare.13290731.v1
title: Additional file 4 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 4: Table S3A-D. Associations between DNA methylation levels and overweight/obesity versus normal weight. Results for CpGs with p-values &lt; 1x10-4 are shown.
DOI: 10.6084/m9.figshare.20115896
title: Numerical investigation of asymmetric weld fusion geometry in laser welding of aluminium alloy with beam oscillation

description: In this work, the asymmetric weld fusion geometry in oscillating laser beam welding (OLBW) of aluminium alloy was reported and investigated using a numerical approach. A multi-physics heat transfer and fluid flow model of OLBW was developed and validated with the corresponding experimental results. The weld fusion geometry, temperature fields, and fluid flow behaviours for four commonly used oscillation modes, line, circle, eight, and infinity, were calculated to analyse the origin of the asymmetric weld fusion geometry. The results show the asymmetry of local heat input along beam travelling path and the fluid flow pattern in the molten pool are the main factors that result in the asymmetric weld fusion geometry in OLBW.
DOI: 10.6084/m9.figshare.13300267
title: Source code from Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability

description: Source code required to run the simulations on CHASTE.
DOI: 10.6084/m9.figshare.20115831
title: Additional file 1 of Using BERT to identify drug-target interactions from whole PubMed

description: Additional file 1. Pmids for 100 articles that are manually validated to contain drug-target interactions.
DOI: 10.6084/m9.figshare.20115896.v1
title: Numerical investigation of asymmetric weld fusion geometry in laser welding of aluminium alloy with beam oscillation

description: In this work, the asymmetric weld fusion geometry in oscillating laser beam welding (OLBW) of aluminium alloy was reported and investigated using a numerical approach. A multi-physics heat transfer and fluid flow model of OLBW was developed and validated with the corresponding experimental results. The weld fusion geometry, temperature fields, and fluid flow behaviours for four commonly used oscillation modes, line, circle, eight, and infinity, were calculated to analyse the origin of the asymmetric weld fusion geometry. The results show the asymmetry of local heat input along beam travelling path and the fluid flow pattern in the molten pool are the main factors that result in the asymmetric weld fusion geometry in OLBW.
DOI: 10.6084/m9.figshare.19582204.v1
title: Additional file 8 of Comparative transcriptome analysis provides insights into the molecular mechanisms of high-frequency hearing differences between the sexes of Odorrana tormota

description: Additional file 8: Table S4. Number of DEGs between different groups in O. tormota.
DOI: 10.6084/m9.figshare.21688988.v1
title: Genetic underpinnings of brain structural connectome for young adults

description: With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain structural connectivity (i.e., structural connectome) which summarizes the anatomical connections between different brain regions is one of the most cutting edge while under-investigated traits; and the genetic influence on the structural connectome variation remains highly elusive. Relying on a landmark imaging genetics study for young adults, we develop a biologically plausible brain network response shrinkage model to comprehensively characterize the relationship between high dimensional genetic variants and the structural connectome phenotype. Under a unified Bayesian framework, we accommodate the topology of brain network and biological architecture within the genome; and eventually establish a mechanistic mapping between genetic biomarkers and the associated brain sub-network units. An efficient expectation-maximization algorithm is developed to estimate the model and ensure computing feasibility. In the application to the Human Connectome Project Young Adult (HCP-YA) data, we establish the genetic underpinnings which are highly interpretable under functional annotation and brain tissue eQTL analysis, for the brain white matter tracts connecting the hippocampus and two cerebral hemispheres. We also show the superiority of our method in extensive simulations.
DOI: 10.25402/cer.20115992.v1
title: Supplementary Materials. Steroid switching in dystrophinopathy treatment: a US Chart review of patient characteristics and clinical outcomes.

description:  Appendix. Case Report Form.
<br>
Supplemental Materials.

  Supplemental   Methods.
 Supplemental Table 1. Data availability.
DOI: 10.6084/m9.figshare.21688994.v1
title: A Random Projection Approach to Hypothesis Tests in High-Dimensional Single-Index Models

description: In this article, we consider the problem of hypothesis testing in high-dimensional single-index models. First, we study the feasibility of applying the classical F-test to a single-index model when the dimension of covariate vector and sample size are of the same order, and derive its asymptotic null distribution and asymptotic local power function. For the ultrahigh-dimensional single-index model, we construct F-statistics based on lower-dimensional random projections of the data, and establish the asymptotic null distribution and the asymptotic local power function of the proposed test statistics for the hypothesis testing of global and partial parameters. The new proposed test possesses the advantages of having a simple structure as well as being easy to compute. We compare the proposed test with other high-dimensional tests and provide sufficient conditions under which the proposed tests are more efficient. We conduct simulation studies to evaluate the finite-sample performances of the proposed tests and demonstrate that it has higher power than some existing methods in the models we consider. The application of real high-dimensional gene expression data is also provided to illustrate the effectiveness of the method. Supplementary materials for this article are available online.
DOI: 10.25402/cer.20115992
title: Supplementary Materials. Steroid switching in dystrophinopathy treatment: a US Chart review of patient characteristics and clinical outcomes.

description:  Appendix. Case Report Form.
<br>
Supplemental Materials.

  Supplemental   Methods.
 Supplemental Table 1. Data availability.
DOI: 10.6084/m9.figshare.21688988
title: Genetic Underpinnings of Brain Structural Connectome for Young Adults

description: With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain structural connectivity (i.e., structural connectome) which summarizes the anatomical connections between different brain regions is one of the most cutting edge while under-investigated traits; and the genetic influence on the structural connectome variation remains highly elusive. Relying on a landmark imaging genetics study for young adults, we develop a biologically plausible brain network response shrinkage model to comprehensively characterize the relationship between high dimensional genetic variants and the structural connectome phenotype. Under a unified Bayesian framework, we accommodate the topology of brain network and biological architecture within the genome; and eventually establish a mechanistic mapping between genetic biomarkers and the associated brain sub-network units. An efficient expectation-maximization algorithm is developed to estimate the model and ensure computing feasibility. In the application to the Human Connectome Project Young Adult (HCP-YA) data, we establish the genetic underpinnings which are highly interpretable under functional annotation and brain tissue eQTL analysis, for the brain white matter tracts connecting the hippocampus and two cerebral hemispheres. We also show the superiority of our method in extensive simulations. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.21688988.v2
title: Genetic Underpinnings of Brain Structural Connectome for Young Adults

description: With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain structural connectivity (i.e., structural connectome) which summarizes the anatomical connections between different brain regions is one of the most cutting edge while under-investigated traits; and the genetic influence on the structural connectome variation remains highly elusive. Relying on a landmark imaging genetics study for young adults, we develop a biologically plausible brain network response shrinkage model to comprehensively characterize the relationship between high dimensional genetic variants and the structural connectome phenotype. Under a unified Bayesian framework, we accommodate the topology of brain network and biological architecture within the genome; and eventually establish a mechanistic mapping between genetic biomarkers and the associated brain sub-network units. An efficient expectation-maximization algorithm is developed to estimate the model and ensure computing feasibility. In the application to the Human Connectome Project Young Adult (HCP-YA) data, we establish the genetic underpinnings which are highly interpretable under functional annotation and brain tissue eQTL analysis, for the brain white matter tracts connecting the hippocampus and two cerebral hemispheres. We also show the superiority of our method in extensive simulations. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.13300267.v1
title: Source code from Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability

description: Source code required to run the simulations on CHASTE.
DOI: 10.6084/m9.figshare.19582207
title: Additional file 9 of Comparative transcriptome analysis provides insights into the molecular mechanisms of high-frequency hearing differences between the sexes of Odorrana tormota

description: Additional file 9: Table S5. 4605 differentially expressed genes in the brain between female and male O. tormota.
DOI: 10.6084/m9.figshare.23786454.v1
title: Statistical Modeling of the Effectiveness of Preventive Maintenance for Repairable Systems

description: Preventive maintenance (PM) is commonly adopted in practice to improve a system’s health condition and reduce the risk of unexpected failures. When a PM action is poorly performed, however, it is likely to have adverse effects on system reliability. We observe this phenomenon when evaluating the effectiveness of a PM program for a fleet of service vehicles based on their four-year operating data. This phenomenon is also commonly reported in the maintenance of vehicles and aircraft. Motivated by this observation, we propose a statistical model for repairable systems by taking potential PM adverse effects into account. In the formulation, the baseline failure process without PM effects is modeled by a non-homogeneous Poisson process. When a PM action is performed, its effect on the failure process is modeled as a multiplicative random effect on the system rate of occurrence of failures. Statistical inference under the proposed model is discussed, and we further develop goodness-of-fit test procedures to validate the adequacy of this model. The above-mentioned service vehicle operating data are used to demonstrate the proposed methods. This article has online supplementary materials.
DOI: 10.6084/m9.figshare.8057768.v1
title: Additional file 1: of Is hysterectomy beneficial in radical cystectomy for female patient with urothelial carcinoma of bladder? A retrospective analysis of consecutive 112 cases from a single institution

description: Information of the patients. This data includes relevant information of all patients enrolled in this study, including Clinicopathologic data and oncologic outcomes. (XLSX 24 kb)
DOI: 10.6084/m9.figshare.8057768
title: Additional file 1: of Is hysterectomy beneficial in radical cystectomy for female patient with urothelial carcinoma of bladder? A retrospective analysis of consecutive 112 cases from a single institution

description: Information of the patients. This data includes relevant information of all patients enrolled in this study, including Clinicopathologic data and oncologic outcomes. (XLSX 24 kb)
DOI: 10.6084/m9.figshare.8057915.v1
title: Additional file 7: of High-density genetic map construction and QTL mapping of first flower node in pepper (Capsicum annuum L.)

description: Table S7. List of 59 candidate genes located in the major QTLs Ffn2.1 and Ffn2.2. (XLSX 21 kb)
DOI: 10.6084/m9.figshare.8057921.v1
title: Additional file 8: of High-density genetic map construction and QTL mapping of first flower node in pepper (Capsicum annuum L.)

description: Table S8. Summary of differential expression genes just before and after the first flower emerging. (XLSX 1683 kb)
DOI: 10.6084/m9.figshare.8057903.v1
title: Additional file 6: of High-density genetic map construction and QTL mapping of first flower node in pepper (Capsicum annuum L.)

description: Table S6. Phenotypic data of FFN of RILs and parents in three seasons. (XLSX 16 kb)
DOI: 10.5281/zenodo.10653740
title: FTIR ZnO (CA, CAT, SA, DHBA, 5ASA)
DOI: 10.5281/zenodo.10653741
title: FTIR ZnO (CA, CAT, SA, DHBA, 5ASA)
DOI: 10.6084/m9.figshare.19582204
title: Additional file 8 of Comparative transcriptome analysis provides insights into the molecular mechanisms of high-frequency hearing differences between the sexes of Odorrana tormota

description: Additional file 8: Table S4. Number of DEGs between different groups in O. tormota.
DOI: 10.13145/bacdive8678.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8679.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8680.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8681.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8682.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8683.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8684.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8685.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive8686.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9381.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9382.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9383.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9384.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9385.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9386.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9387.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive9388.20170829.2
title: Corallococcus coralloides (Thaxter 1892) Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive10318.20170829.2
title: Nannocystis pusilla Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive10319.20170829.2
title: Nannocystis pusilla Reichenbach 2007

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive10320.20170829.2
title: Nannocystis exedens subsp. pulla Reichenbach et al.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive10321.20170829.2
title: Nannocystis exedens subsp. aggregans Reichenbach et al.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive10322.20170829.2
title: Nannocystis exedens subsp. aggregans Reichenbach et al.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive10323.20170829.2
title: Nannocystis exedens subsp. aggregans Reichenbach et al.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.