cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17876/rave/dr.6/fields/20100312_0819m57
title: RAVE Field 20100312_0819m57

description: A field from the RAVE survey
DOI: 10.17876/rave/dr.6/fields/20100312_1057m45
title: RAVE Field 20100312_1057m45

description: A field from the RAVE survey
DOI: 10.17876/rave/dr.6/fields/20100312_1119m52
title: RAVE Field 20100312_1119m52

description: A field from the RAVE survey
DOI: 10.6084/m9.figshare.7808012
title: Additional file 2.ab1

description: Sanger sequencing trace with indel
DOI: 10.6084/m9.figshare.7807988
title: Institutional microsite animations

description: These are the animations displayed on our website (linked in the references field), available for you to use in your own promotional materials.
DOI: 10.6084/m9.figshare.7808012.v1
title: Additional file 2.ab1

description: Sanger sequencing trace with indel
DOI: 10.6084/m9.figshare.7807988.v1
title: Institutional microsite animations

description: These are the animations displayed on our website (linked in the references field), available for you to use in your own promotional materials.
DOI: 10.6084/m9.figshare.7807979
title: Hospital costs associated with intraoperative hypotension among non-cardiac surgical patients in the US: a simulation model

description: <b>Objective:</b> Recent studies indicate intraoperative hypotension, common in non-cardiac surgical patients, is associated with myocardial injury, acute kidney injury, and mortality. This study extends on these findings by quantifying the association between intraoperative hypotension and hospital expenditures in the US. <b>Methods:</b> Monte Carlo simulations (10,000 trial per simulation) based on current epidemiological and cost outcomes literature were developed for both acute kidney injury (AKI) and myocardial injury in non-cardiac surgery (MINS). For AKI, three models with different epidemiological assumptions (two models based on observational studies and one model based on a randomized control trial [RCT]) estimate the marginal probability of AKI conditional on intraoperative hypotension status. Similar models are also developed for MINS (except for the RCT case). Marginal probabilities of AKI and MINS sequelae (myocardial infarction, congestive heart failure, stroke, cardiac catheterization, and percutaneous coronary intervention) are multiplied by marginal cost estimates for each outcome to evaluate costs associated with intraoperative hypotension. <b>Results:</b> The unadjusted (adjusted) model found hypotension control lowers the absolute probability of AKI by 2.2% (0.7%). Multiplying these probabilities by the marginal cost of AKI, the unadjusted (adjusted) AKI model estimated a cost reduction of $272 [95% CI = $223–$321] ($86 [95% CI = $47–$127]) per patient. The AKI model based on relative risks from the RCT had a mean cost reduction estimate of $281 (95% CI = –$346–$750). The unadjusted (adjusted) MINS model yielded a cost reduction of $186 [95% CI = $73–$393] ($33 [95% CI = $10–$77]) per patient. <b>Conclusions:</b> The model results suggest improved intraoperative hypotension control in a hospital with an annual volume of 10,000 non-cardiac surgical patients is associated with mean cost reductions ranging from $1.2–$4.6 million per year. Since the magnitude of the RCT mean estimate is similar to the unadjusted observational model, the institutional costs are likely at the upper end of this range.
DOI: 10.6084/m9.figshare.7807979.v2
title: Hospital costs associated with intraoperative hypotension among non-cardiac surgical patients in the US: a simulation model

description: <b>Objective:</b> Recent studies indicate intraoperative hypotension, common in non-cardiac surgical patients, is associated with myocardial injury, acute kidney injury, and mortality. This study extends on these findings by quantifying the association between intraoperative hypotension and hospital expenditures in the US. <b>Methods:</b> Monte Carlo simulations (10,000 trial per simulation) based on current epidemiological and cost outcomes literature were developed for both acute kidney injury (AKI) and myocardial injury in non-cardiac surgery (MINS). For AKI, three models with different epidemiological assumptions (two models based on observational studies and one model based on a randomized control trial [RCT]) estimate the marginal probability of AKI conditional on intraoperative hypotension status. Similar models are also developed for MINS (except for the RCT case). Marginal probabilities of AKI and MINS sequelae (myocardial infarction, congestive heart failure, stroke, cardiac catheterization, and percutaneous coronary intervention) are multiplied by marginal cost estimates for each outcome to evaluate costs associated with intraoperative hypotension. <b>Results:</b> The unadjusted (adjusted) model found hypotension control lowers the absolute probability of AKI by 2.2% (0.7%). Multiplying these probabilities by the marginal cost of AKI, the unadjusted (adjusted) AKI model estimated a cost reduction of $272 [95% CI = $223–$321] ($86 [95% CI = $47–$127]) per patient. The AKI model based on relative risks from the RCT had a mean cost reduction estimate of $281 (95% CI = –$346–$750). The unadjusted (adjusted) MINS model yielded a cost reduction of $186 [95% CI = $73–$393] ($33 [95% CI = $10–$77]) per patient. <b>Conclusions:</b> The model results suggest improved intraoperative hypotension control in a hospital with an annual volume of 10,000 non-cardiac surgical patients is associated with mean cost reductions ranging from $1.2–$4.6 million per year. Since the magnitude of the RCT mean estimate is similar to the unadjusted observational model, the institutional costs are likely at the upper end of this range.
DOI: 10.6084/m9.figshare.7807979.v1
title: Hospital costs associated with intraoperative hypotension among non-cardiac surgical patients in the US: a simulation model

description: <b>Objective:</b> Recent studies indicate intraoperative hypotension, common in non-cardiac surgical patients, is associated with myocardial injury, acute kidney injury and mortality. This study extends on these findings by quantifying the association between intraoperative hypotension and hospital expenditures in the United States. <b>Methods:</b> Monte Carlo simulations (10,000 trial per simulation) based on current epidemiological and cost outcomes literature were developed for both acute kidney injury (AKI) and myocardial injury in non-cardiac surgery (MINS). For AKI, three models with different epidemiological assumptions (two models based on observational studies and one model based on a randomized control trial [RCT]) estimate of the marginal probability of AKI conditional on intraoperative hypotension status. Similar models are also developed for MINS (except for the RCT case). Marginal probabilities of AKI and MINS sequelae (myocardial infarction, congestive heart failure, stroke, cardiac catheterization and percutaneous coronary intervention) are multiplied by marginal cost estimates for each outcome to evaluate costs associated with intraoperative hypotension. <b>Results:</b> The unadjusted (adjusted) model found hypotension control lowers the absolute probability of AKI by 2.2% (0.7%). Multiplying these probabilities by the marginal cost of AKI, the unadjusted (adjusted) AKI model estimated a cost reduction of $272 [95% CI: $223-$321] ($86 [95% CI: $47-$127]) per patient. The AKI model based on relative risks from the RCT had a mean cost reduction estimate of $281 (95% CI:-$346-$750). The unadjusted (adjusted) MINS model yielded a cost reduction of $186 [95% CI: $73-$393] ($33 [95% CI: $10-$77]) per patient. <b>Conclusions:</b> The model results suggest improved intraoperative hypotension control in a hospital with annual volume 10,000 non-cardiac surgical patients is associated with mean cost reductions ranging from $1.2 to $4.6 million per year. Since the magnitude of the RCT mean estimate is similar to the unadjusted observational model, the institutional costs are likely at the upper end of this range.
DOI: 10.6084/m9.figshare.7807955
title: Supplementary Material for: Dehydroabietic Acid Induces Regeneration of Collagen Fibers in Ultraviolet B-Irradiated Human Dermal Fibroblasts and Skin Equivalents

description: <b><i>Background/Aims:</i></b> Dehydroabietic acid (DAA) is a natural phytochemical found in red pine trees and herbal plants. While DAA and its derivatives are known for improving diabetes and hyperlipidemia, the antiaging effect and its underlying mechanisms of DAA on skin have not been fully examined. Here, we assessed the antiaging effects of DAA on human dermal fibroblasts and skin equivalents. <b><i>Methods:</i></b> We investigated the effect of DAA on the secretion of type I procollagen and matrix metalloproteinase-1 (MMP-1) in ultraviolet B (UVB)-irradiated neonatal normal human dermal fibroblasts (NHDFn). Using nonlinear optical imaging techniques, we visualized quantitative and qualitative changes of collagen fibers by DAA treatment in human skin equivalent models. <b><i>Results:</i></b> DAA induces increases in type I procollagen secretion when treated on UVB-irradiated NHDFn. DAA also downregulates secretion of MMP-1 through the inhibition of the JNK signaling pathway. In human skin equivalent models, we successfully visualized the spatial distribution of collagen fibers in the dermis and found that quantity, diameter, and arrangement of collagen fibers in the dermis were significantly improved by DAA treatment. <b><i>Conclusion:</i></b> Our results suggest that DAA could be a useful agent for improving skin photoaging through the protection and regeneration of collagen fibers in skin.
DOI: 10.6084/m9.figshare.7807955.v1
title: Supplementary Material for: Dehydroabietic Acid Induces Regeneration of Collagen Fibers in Ultraviolet B-Irradiated Human Dermal Fibroblasts and Skin Equivalents

description: <b><i>Background/Aims:</i></b> Dehydroabietic acid (DAA) is a natural phytochemical found in red pine trees and herbal plants. While DAA and its derivatives are known for improving diabetes and hyperlipidemia, the antiaging effect and its underlying mechanisms of DAA on skin have not been fully examined. Here, we assessed the antiaging effects of DAA on human dermal fibroblasts and skin equivalents. <b><i>Methods:</i></b> We investigated the effect of DAA on the secretion of type I procollagen and matrix metalloproteinase-1 (MMP-1) in ultraviolet B (UVB)-irradiated neonatal normal human dermal fibroblasts (NHDFn). Using nonlinear optical imaging techniques, we visualized quantitative and qualitative changes of collagen fibers by DAA treatment in human skin equivalent models. <b><i>Results:</i></b> DAA induces increases in type I procollagen secretion when treated on UVB-irradiated NHDFn. DAA also downregulates secretion of MMP-1 through the inhibition of the JNK signaling pathway. In human skin equivalent models, we successfully visualized the spatial distribution of collagen fibers in the dermis and found that quantity, diameter, and arrangement of collagen fibers in the dermis were significantly improved by DAA treatment. <b><i>Conclusion:</i></b> Our results suggest that DAA could be a useful agent for improving skin photoaging through the protection and regeneration of collagen fibers in skin.
DOI: 10.6084/m9.figshare.7807928
title: Biomedical Word Embeddings for Spanish: Development and Evaluation

description: Word embeddings are representations of words in a dense vector space. Although they are not recent phenomena in Natural Language Processing (NLP), they have gained momentum after the recent developments of neural methods and Word2Vec. Regarding their applications in medical and clinical NLP, they are invaluable resources when training in-domain named entity recognition systems, classifiers or taggers, for instance. Thus, the development of tailored word embeddings for medical NLP is of great interest. However, we identified a gap in the literature which we aim to fill in this paper: the availability of embeddings for medical NLP in Spanish, as well as a standardized form of intrinsic evaluation. Since most work has been done for English, some established datasets for intrinsic evaluation are already available. In this paper, we show the steps we employed to adapt such datasets for the first time to Spanish, of particular relevance due to the considerable volume of EHRs in this language, as well as the creation of in-domain medical word embeddings for the Spanish using the state-of-the-art FastText model. We performed intrinsic evaluation with our adapted datasets, as well as extrinsic evaluation with a named entity recognition systems using a baseline embedding of general-domain. Both experiments proved that our embeddings are suitable for use in medical NLP in the Spanish language, and are more accurate than general-domain ones.
DOI: 10.6084/m9.figshare.7807928.v1
title: Biomedical Word Embeddings for Spanish: Development and Evaluation

description: Word embeddings are representations of words in a dense vector space. Although they are not recent phenomena in Natural Language Processing (NLP), they have gained momentum after the recent developments of neural methods and Word2Vec. Regarding their applications in medical and clinical NLP, they are invaluable resources when training in-domain named entity recognition systems, classifiers or taggers, for instance. Thus, the development of tailored word embeddings for medical NLP is of great interest. However, we identified a gap in the literature which we aim to fill in this paper: the availability of embeddings for medical NLP in Spanish, as well as a standardized form of intrinsic evaluation. Since most work has been done for English, some established datasets for intrinsic evaluation are already available. In this paper, we show the steps we employed to adapt such datasets for the first time to Spanish, of particular relevance due to the considerable volume of EHRs in this language, as well as the creation of in-domain medical word embeddings for the Spanish using the state-of-the-art FastText model. We performed intrinsic evaluation with our adapted datasets, as well as extrinsic evaluation with a named entity recognition systems using a baseline embedding of general-domain. Both experiments proved that our embeddings are suitable for use in medical NLP in the Spanish language, and are more accurate than general-domain ones.
DOI: 10.6084/m9.figshare.7807799
title: ColPortal_ClinicalCases

description: Metadata about clinical cases
DOI: 10.6084/m9.figshare.7807772
title: Additional data for this article "Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle" Manuscript ID is AnGen-18-10-0278.(Aniaml Genetics)

description: The data content includes: collecting the value of ion concentration in cow blood as phenotype data (txt); SNP data and map data obtained after genome-wide scan comparison(txt); Results calculated by FarmCPU model(csv); Manhattan plots and QQ plots(pdf).
DOI: 10.6084/m9.figshare.7807769
title: Additional file 9: of De novo transcriptome assembly of the cubomedusa Tripedalia cystophora, including the analysis of a set of genes involved in peptidergic neurotransmission

description: A table, including accession numbers of biogenic amine GPCRs, neuropeptide GPCRs, LGRs, and opsins present in the transcriptomes from T. cystophora and A. alata. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.7807769.v1
title: Additional file 9: of De novo transcriptome assembly of the cubomedusa Tripedalia cystophora, including the analysis of a set of genes involved in peptidergic neurotransmission

description: A table, including accession numbers of biogenic amine GPCRs, neuropeptide GPCRs, LGRs, and opsins present in the transcriptomes from T. cystophora and A. alata. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.7807772.v2
title: Additional data for this article "Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle" Manuscript ID is AnGen-18-10-0278.(Aniaml Genetics)

description: The data content includes: collecting the value of ion concentration in cow blood as phenotype data (txt); SNP data and map data obtained after genome-wide scan comparison(txt); Results calculated by FarmCPU model(csv); Manhattan plots and QQ plots(pdf).
DOI: 10.6084/m9.figshare.7807715
title: Additional file 1: of Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

description: Electrocardiogram (ECG) data correlation with urine-proteins of two groups with different type of autonomic regulation. (XLS 185 kb)
DOI: 10.6084/m9.figshare.7807721
title: Additional file 2: of Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

description: Label-free data for urine-protein list of two groups with different type of autonomic regulation. (XLSX 58 kb)
DOI: 10.6084/m9.figshare.7807721.v1
title: Additional file 2: of Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

description: Label-free data for urine-protein list of two groups with different type of autonomic regulation. (XLSX 58 kb)
DOI: 10.6084/m9.figshare.7807706
title: Additional file 3: of Systems based analysis of human embryos and gene networks involved in cell lineage allocation

description: Supplemental Tables (XLSX 274 kb)
DOI: 10.6084/m9.figshare.7807715.v1
title: Additional file 1: of Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

description: Electrocardiogram (ECG) data correlation with urine-proteins of two groups with different type of autonomic regulation. (XLS 185 kb)
DOI: 10.6084/m9.figshare.7807706.v1
title: Additional file 3: of Systems based analysis of human embryos and gene networks involved in cell lineage allocation

description: Supplemental Tables (XLSX 274 kb)
DOI: 10.6084/m9.figshare.12881837
title: SLA_30May2015

description: Gridded SLA data from cds.climate.copernicus.eu for 30 May 2015.
DOI: 10.6084/m9.figshare.12881837.v2
title: SLA_30May2015

description: Gridded SLA data from cds.climate.copernicus.eu for 30 May 2015.
DOI: 10.6084/m9.figshare.12881837.v1
title: SLA_30May2015

description: Gridded SLA data from cds.climate.copernicus.eu for 30 May 2015.
DOI: 10.6084/m9.figshare.7807607
title: Additional file 3: of Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol

description: Data extraction form field description. (XLSX 11Â kb)
DOI: 10.6084/m9.figshare.7807607.v1
title: Additional file 3: of Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol

description: Data extraction form field description. (XLSX 11Â kb)
DOI: 10.6084/m9.figshare.7807550
title: MOESM6 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 6. Annotated sequence of the glass-tomato plasmid that was used for Platynereis microinjections.
DOI: 10.6084/m9.figshare.7807550.v1
title: MOESM6 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 6. Annotated sequence of the glass-tomato plasmid that was used for Platynereis microinjections.
DOI: 10.6084/m9.figshare.7807517
title: Additional file 1: of The ASSIST Study - The BD Odon Device for assisted vaginal birth: a safety and feasibility study

description: Case report forms. Copies of the case report forms for the ASSIST Study. (ZIP 830 kb)
DOI: 10.6084/m9.figshare.7807520
title: MOESM20 of Modular co-option of cardiopharyngeal genes during non-embryonic myogenesis

description: Additional file 20. TableÂ 2: Correlations coefficient of transcriptomic data for candidate genes &gt;â 1.
DOI: 10.6084/m9.figshare.7807520.v1
title: MOESM20 of Modular co-option of cardiopharyngeal genes during non-embryonic myogenesis

description: Additional file 20. TableÂ 2: Correlations coefficient of transcriptomic data for candidate genes &gt;â 1.
DOI: 10.6084/m9.figshare.7807514
title: MOESM5 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 5. Example confocal stacks.
DOI: 10.6084/m9.figshare.7807517.v1
title: Additional file 1: of The ASSIST Study - The BD Odon Device for assisted vaginal birth: a safety and feasibility study

description: Case report forms. Copies of the case report forms for the ASSIST Study. (ZIP 830 kb)
DOI: 10.6084/m9.figshare.7807505
title: MOESM4 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 4. Subset of glass-like sequences for which the DNA-binding affinity was investigated.
DOI: 10.6084/m9.figshare.7807505.v1
title: MOESM4 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 4. Subset of glass-like sequences for which the DNA-binding affinity was investigated.
DOI: 10.6084/m9.figshare.7807514.v1
title: MOESM5 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 5. Example confocal stacks.
DOI: 10.6084/m9.figshare.7807499
title: MOESM3 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 3. Glass phylogenetic tree and sequences data.
DOI: 10.6084/m9.figshare.7807490
title: MOESM2 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 2. Platynereis glass supplementary nucleotide sequences (both genomic and transcriptomic).
DOI: 10.6084/m9.figshare.7807499.v1
title: MOESM3 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 3. Glass phylogenetic tree and sequences data.
DOI: 10.6084/m9.figshare.7807490.v1
title: MOESM2 of Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

description: Additional file 2. Platynereis glass supplementary nucleotide sequences (both genomic and transcriptomic).
DOI: 10.6084/m9.figshare.7807403
title: Additional file 7: of Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon)

description: Table S4. GO BP enrichment of the DEGs of seven Fuzzy c-means clusters. (XLSX 72 kb)
DOI: 10.6084/m9.figshare.7807406
title: Additional file 8: of Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon)

description: Table S5. GO BP enrichment of the genes of nine WGCNA modules. (XLSX 508 kb)
DOI: 10.6084/m9.figshare.7807409
title: Additional file 1: of Engineer complete resistance to Cotton Leaf Curl Multan virus by the CRISPR/Cas9 system in Nicotiana benthamiana

description: Table S1. gRNA candidates for IR and C1 of CLCuMuV. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.7807406.v1
title: Additional file 8: of Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon)

description: Table S5. GO BP enrichment of the genes of nine WGCNA modules. (XLSX 508 kb)
DOI: 10.6084/m9.figshare.7807409.v1
title: Additional file 1: of Engineer complete resistance to Cotton Leaf Curl Multan virus by the CRISPR/Cas9 system in Nicotiana benthamiana

description: Table S1. gRNA candidates for IR and C1 of CLCuMuV. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.7807403.v1
title: Additional file 7: of Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon)

description: Table S4. GO BP enrichment of the DEGs of seven Fuzzy c-means clusters. (XLSX 72 kb)
DOI: 10.6084/m9.figshare.7807391
title: MOESM2 of Tarsier Goggles: a virtual reality tool for experiencing the optics of a dark-adapted primate visual system

description: Additional file 2. Data containing user responses to questions listed in TableÂ 1. Responses that neglected to answer the question at hand were omitted from the data.