cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.57745/2b0ox9
title: pb_ext_edta_CE_OK_C1.tif

description: :unav
DOI: 10.57745/uij9ol
title: ni_ext_edta_050_QRF1.tif

description: :unav
DOI: 10.57745/grjmwr
title: hg_tot_hf_CE_OK_C1.tif

description: :unav
DOI: 10.57745/vjzofq
title: zn_ext_edta_CE_OK_C1.tif

description: :unav
DOI: 10.57745/4aqhlc
title: ni_tot_hf_CE_KED_C1.tif

description: :unav
DOI: 10.57745/wwjzyg
title: pb_tot_hf_CE_KED_C1.tif

description: :unav
DOI: 10.57745/dtmofy
title: zn_tot_hf_CE_KED_C1.tif

description: :unav
DOI: 10.57745/thegfu
title: cr_tot_hf_050_QRF1.tif

description: :unav
DOI: 10.57745/rngyci
title: mo_tot_hf_CE_KED_C2.tif

description: :unav
DOI: 10.57745/ao15yd
title: cr_tot_hf_050_QRF2.tif

description: :unav
DOI: 10.57745/udd4lp
title: cd_tot_hf_CE_KED_C2.tif

description: :unav
DOI: 10.57745/97duo0
title: pb_tot_hf_CE_KED_C2.tif

description: :unav
DOI: 10.57745/4hhnuk
title: ni_tot_hf_050_QRF2.tif

description: :unav
DOI: 10.57745/yx9oya
title: cu_tot_hf_CE_KED_C2.tif

description: :unav
DOI: 10.57745/o8klpo
title: tl_tot_hf_050_QRF2.tif

description: :unav
DOI: 10.57745/fyn37k
title: co_tot_hf_CE_KED_C2.tif

description: :unav
DOI: 10.57745/318403
title: zn_tot_hf_CE_KED_C2.tif

description: :unav
DOI: 10.57745/5ow9am
title: pb_ext_edta_CE_OK_C2.tif

description: :unav
DOI: 10.57745/9mmdht
title: cr_ext_edta_CE_OK_C2.tif

description: :unav
DOI: 10.57745/cphe0e
title: cd_ext_edta_CE_KED_C2.tif

description: :unav
DOI: 10.57745/okdfzx
title: zn_ext_edta_CE_OK_C2.tif

description: :unav
DOI: 10.57745/5ftoii
title: ni_ext_edta_CE_OK_C2.tif

description: :unav
DOI: 10.57745/e5tjik
title: cu_ext_edta_CE_KED_C2.tif

description: :unav
DOI: 10.57745/fqafcn
title: zn_tot_hf_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/nubx4m
title: mo_tot_hf_095_CE_OK_C1.tif

description: :unav
DOI: 10.57745/f5gjdk
title: tl_tot_hf_095_CE_OK_C1.tif

description: :unav
DOI: 10.57745/iv8qrh
title: cu_tot_hf_095_QRF1.tif

description: :unav
DOI: 10.57745/bcfnxn
title: co_tot_hf_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/emmron
title: cd_tot_hf_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/ln3tnn
title: as_tot_hf_095_CE_OK_C1.tif

description: :unav
DOI: 10.57745/e3kkkq
title: pb_tot_hf_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/zpz7px
title: hg_tot_hf_095_CE_OK_C1.tif

description: :unav
DOI: 10.57745/7vnkxy
title: ni_tot_hf_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/ylu8h7
title: cr_tot_hf_095_QRF1.tif

description: :unav
DOI: 10.57745/eb7exj
title: pb_ext_edta_095_CE_OK_C1.tif

description: :unav
DOI: 10.57745/bfghyk
title: cd_ext_edta_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/wi0cwx
title: cu_ext_edta_095_CE_KED_C1.tif

description: :unav
DOI: 10.57745/3qfnpg
title: zn_ext_edta_095_CE_OK_C1.tif

description: :unav
DOI: 10.57745/ogtp2n
title: cr_ext_edta_095_QRF1.tif

description: :unav
DOI: 10.57745/inhbbk
title: tl_tot_hf_095_QRF2.tif

description: :unav
DOI: 10.57745/ohg1wv
title: ni_ext_edta_095_QRF1.tif

description: :unav
DOI: 10.57745/jujg5q
title: zn_tot_hf_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/lp5b8x
title: cu_tot_hf_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/ptgdgq
title: mo_tot_hf_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/rzfh9t
title: co_tot_hf_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/uvmmec
title: cd_tot_hf_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/irwcbn
title: ni_tot_hf_095_QRF2.tif

description: :unav
DOI: 10.57745/s3hsod
title: cr_tot_hf_095_QRF2.tif

description: :unav
DOI: 10.57745/hneaku
title: pb_tot_hf_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/yoz6ze
title: ni_ext_edta_095_CE_OK_C2.tif

description: :unav
DOI: 10.57745/0et6mc
title: cd_ext_edta_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/7bvt9k
title: cr_ext_edta_095_CE_OK_C2.tif

description: :unav
DOI: 10.57745/t3naqc
title: cu_ext_edta_095_CE_KED_C2.tif

description: :unav
DOI: 10.57745/i6y7fl
title: zn_ext_edta_095_CE_OK_C2.tif

description: :unav
DOI: 10.57745/wbzbwl
title: pb_ext_edta_095_CE_OK_C2.tif

description: :unav
DOI: 10.57745/vruzam
title: pb_tot_hf_005_CE_KED_C1.tif

description: :unav
DOI: 10.57745/mcuc7w
title: zn_tot_hf_005_CE_KED_C1.tif

description: :unav
DOI: 10.57745/mi2r9m
title: co_tot_hf_005_CE_KED_C1.tif

description: :unav
DOI: 10.57745/ciklkr
title: tl_tot_hf_005_CE_OK_C1.tif

description: :unav
DOI: 10.57745/x4xqan
title: cu_tot_hf_005_QRF1.tif

description: :unav
DOI: 10.57745/tfd6rz
title: cr_tot_hf_005_QRF1.tif

description: :unav
DOI: 10.57745/l2phkt
title: ni_tot_hf_005_CE_KED_C1.tif

description: :unav
DOI: 10.57745/uaaylg
title: mo_tot_hf_005_CE_OK_C1.tif

description: :unav
DOI: 10.57745/7linox
title: as_tot_hf_005_CE_OK_C1.tif

description: :unav
DOI: 10.57745/gycoj4
title: hg_tot_hf_005_CE_OK_C1.tif

description: :unav
DOI: 10.57745/reftaj
title: cd_tot_hf_005_CE_KED_C1.tif

description: :unav
DOI: 10.17632/7hvcm36r98.1
title: Numerical study of the effects of lateral blockage and free surface on the performance of a novel vertical-axis turbine

description: Numerical simulation data in the paper “Numerical study of the effects of lateral blockage and free surface on the performance of a novel vertical-axis turbine”
DOI: 10.57745/nptktj
title: pb_ext_edta_005_CE_OK_C1.tif

description: :unav
DOI: 10.57745/gelvqv
title: zn_ext_edta_005_CE_OK_C1.tif

description: :unav
DOI: 10.57745/9zx21f
title: ni_ext_edta_005_QRF1.tif

description: :unav
DOI: 10.57745/ksrcqg
title: cr_ext_edta_005_QRF1.tif

description: :unav
DOI: 10.57745/mej1qb
title: cu_ext_edta_005_CE_KED_C1.tif

description: :unav
DOI: 10.57745/acy1kd
title: cd_ext_edta_005_CE_KED_C1.tif

description: :unav
DOI: 10.57745/2una4e
title: ni_tot_hf_005_QRF2.tif

description: :unav
DOI: 10.57745/xm1ckk
title: pb_tot_hf_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/9ymntr
title: tl_tot_hf_005_QRF2.tif

description: :unav
DOI: 10.57745/fuau1y
title: cd_tot_hf_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/fc6bsa
title: cu_tot_hf_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/phbf1j
title: mo_tot_hf_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/hnyyea
title: co_tot_hf_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/ouilvw
title: cr_tot_hf_005_QRF2.tif

description: :unav
DOI: 10.57745/vop5e1
title: zn_tot_hf_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/9fbal2
title: cd_ext_edta_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/yaugrd
title: pb_ext_edta_005_CE_OK_C2.tif

description: :unav
DOI: 10.57745/wus6hr
title: zn_ext_edta_005_CE_OK_C2.tif

description: :unav
DOI: 10.57745/ebk1pa
title: cu_ext_edta_005_CE_KED_C2.tif

description: :unav
DOI: 10.57745/gei2l8
title: ni_ext_edta_005_CE_OK_C2.tif

description: :unav
DOI: 10.57745/axbdvy
title: cr_ext_edta_005_CE_OK_C2.tif

description: :unav
DOI: 10.57745/znqbrj
title: cd_tot_hf_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/cmri6g
title: pb_tot_hf_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/xz2dsn
title: mo_tot_hf_std_CE_OK_C1.tif

description: :unav
DOI: 10.57745/ya6nls
title: as_tot_hf_std_CE_OK_C1.tif

description: :unav
DOI: 10.57745/vopdkg
title: co_tot_hf_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/jdgskt
title: tl_tot_hf_std_CE_OK_C1.tif

description: :unav
DOI: 10.57745/akhebv
title: zn_tot_hf_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/bfvkxi
title: hg_tot_hf_std_CE_OK_C1.tif

description: :unav
DOI: 10.57745/nvfwh5
title: ni_tot_hf_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/rh6vuo
title: pb_ext_edta_std_CE_OK_C1.tif

description: :unav
DOI: 10.6084/m9.figshare.24080373.v1
title: Supplementary Material for: Burgers, fast foods, and increased associated risk for atopic dermatitis: A cross-sectional study of dietary habits among young Chinese adults in Singapore/Malaysia

description: Background: We see increasing evidence that dietary and nutrients factors play a pivotal role in allergic diseases and recent global findings suggest that dietary habits influence the pathogenesis of atopic dermatitis (AD). Frequent consumption of fast food diets are associated with AD development. Despite the rising prevalence of AD in Asia, efforts in investigating the role of dietary habits and AD in adults are still lacking. Methods: We evaluated the association of foods and dietary habits with AD presentation using our population established for the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES). Dietary habits profiles of 11494 young Chinese adults (1550 AD cases/ 2978 non-atopic controls/6386 atopic controls) were assessed by an investigator-administered questionnaire. AD cases were further evaluated for their chronicity (550 chronic) and severity (628 moderate-to-severe). Additionally, we derived a novel food index, Quality of Diet based on Glycaemic Index Score (QDGIS), to examine the association of dietary habits of GI and foods with AD and various AD phenotypes. Results: The majority of AD subjects are distributed in the good (37.1%) and moderate (36.2%) QDGIS classes. From the multivariate analyses for age and gender, a moderate QDGIS class was significantly associated with a lower odds of AD (Adjusted Odds Ratio (AOR): 0.844; 95% Confidence Interval (CI): 0.719-0.991; p &lt;0.05) and moderate/severe AD (AOR: 0.839; 95% CI: 0.714-0.985; p &lt;0.05). A good QDGIS class was only significantly associated with a lower odds of chronic AD (AOR: 0.769; 95% CI: 0.606-09761; p &lt;0.05). Among high GI foods, frequent consumption of burgers/fast food was strongly associated with an increased risk of chronic and severe AD. Among low GI foods, increased intake frequencies of fruits, vegetables, and pulses decreased the odds of AD. Finally, we identified significant associations between frequent seafood, margarine, butter, and pasta consumption with an increased odds of AD despite them having little GI values. Conclusion: While genetic components are well-established in their risks associated with increased AD prevalence, there is still a lack of a focus epidemiology study associating dietary influence with AD. Based on the first allergic epidemiology study conducted here in Singapore and Malaysia, it laid the groundwork to guide potential dietary interventions from changing personal eating habits.
DOI: 10.57745/adudt6
title: cd_ext_edta_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/fihokj
title: zn_ext_edta_std_CE_OK_C1.tif

description: :unav
DOI: 10.57745/x27unj
title: zn_tot_hf_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/xp2elw
title: cu_ext_edta_std_CE_KED_C1.tif

description: :unav
DOI: 10.57745/er3ecc
title: cd_tot_hf_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/ohmpvb
title: cu_tot_hf_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/cxfh3c
title: co_tot_hf_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/pgje9a
title: mo_tot_hf_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/ipzxqc
title: pb_tot_hf_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/w0poyx
title: cd_ext_edta_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/3i2l3f
title: ni_ext_edta_std_CE_OK_C2.tif

description: :unav
DOI: 10.57745/gc9qv7
title: zn_ext_edta_std_CE_OK_C2.tif

description: :unav
DOI: 10.57745/sfkisd
title: pb_ext_edta_std_CE_OK_C2.tif

description: :unav
DOI: 10.57745/uoqlvb
title: cu_ext_edta_std_CE_KED_C2.tif

description: :unav
DOI: 10.57745/h2zmci
title: cr_ext_edta_std_CE_OK_C2.tif

description: :unav
DOI: 10.25625/fnr4ex/zrckex
title: EMTMET_final_Dataset_2022_03_09.tab

description: :unav
DOI: 10.25625/fnr4ex
title: Combined Biomarker System Predicts Prognosis in Patients with Metastatic Oral Squamous Cell Carcinoma

description: Expression profiles of connexin 43, EMMPRIN, E-cadherin, and vimentin quantified by immunohistochemistry during the metastatic process of OSCC.
DOI: 10.34740/kaggle/ds/3783590
title: AnuraSet v2.0.0 Raw
DOI: 10.6084/m9.figshare.24125301.v1
title: Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology.

description: Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using immunohistochemistry in 163-BTCs patients. We identified MMR proficiency (pMMR)/deficiency (dMMR) according to the loss of MMR proteins (MLH-1, PMS-2, MSH-2, MSH-6). The primary objective of the study was to assess the incidence of dMMR in BTCs; the secondary purpose was to explore its association with prognosis and clinical features. Results: dMMR was recorded in 9 patients and it was strongly associated with mucinous histology (p&lt;0.01). Regarding the prognostic effect, in 122-radically resected patients, disease-free-survival (DFS) resulted significantly shorter in dMMR-patients compared to pMMR-patients (10.7 vs 31.3 months, p = 0.025) and so did nodal status (48.2 vs 15.3 months in N0 vs N+) (p &lt; 0.01). Moreover, dMMR confirmed its prognostic role in terms of DFS at multivariate analysis (p = 0.03), together with nodal status (p = 0.01) and resection margin (p = 0.03). In 103 M+ patients (encompassing 41 metastatic de novo and 62 recurred after surgery patients) there weren’t differences between dMMR and pMMR regarding survival analyses. Discussion/Conclusions: dMMR status is strongly correlated with mucinous histology and represents an independent prognostic factor in terms of disease-relapse in patients with resected BTC.
DOI: 10.17632/c65xrg846s.1
title: Game addiction data

description: Game addiction unstructured Twitter data, labeled.
DOI: 10.6084/m9.figshare.23551605
title: Genome-wide association study of hippocampal BOLD-CBF correlation in Han Chinese population

description: GWAS summary of hippocampal BOLD-CBF correlation in Han Chinese population
DOI: 10.6084/m9.figshare.24071004.v1
title: Supplementary Material for: Next generation sequencing of breast cancer in the neoadjuvant setting

description: Introduction: Many patients with locally advanced breast cancer are proposed to neoadjuvant chemotherapy (NAT) before surgery. Only some of them achieve a pathological complete response (pCR). The determination of gene somatic alterations using Next Generation Sequencing (NGS) in the non-pCR tumors is important, in order to identify potential opportunities of treatment for the patients, if targeted therapies are available. Methods: Breast cancer tissue samples of 31 patients, collected before NAT, were analyzed by NGS using the Oncomine™ Comprehensive Assay Plus (OCA-Plus) panel. Results: 12 patients achieved pCR after NAT. ERBB2 gene alterations were the most frequent in this cohort of pCR patients, followed by BRCA 1 and 2, MYC, TP53, PIK3CA and MET alterations. Tumours that did not achieve a pCR were mainly triple negative. In this subgroup some BRCA 1 and 2 and PIK3CA gene alterations were identified, as well as TP53 mutations. The NGS panel employed in this study also allowed for the determination of tumor mutation burden (TMB). Discussion/Conclusion: This study showcases the significance of employing comprehensive genomic testing in breast cancer cases, primarily due to the scarcity of specific target assays. The detection of somatic mutations, coupled with the availability of targeted therapies, holds promise as a potential therapeutic avenue to enhance tumor response rates during NAT, or as a complementary treatment following surgery. Moreover, evaluating the TMB in non-pCR samples could serve as a valuable criterion for selecting patients suitable for immunotherapy. Further exploration through clinical trials is imperative to investigate these prospects.
DOI: 10.17632/3p76z7n4vg.1
title: Problem Instances: Operative Service Delivery Planning in the Context of Product-Service Systems

description: The provided instances are randomly generated to test and validate optimization algorithms for the Operative Service Delivery Planning in the context of Product-Service Systems with focus on availability-based business models.
DOI: 10.17632/3p76z7n4vg.2
title: Problem Instances: Operative Service Delivery Planning in the Context of Product-Service Systems

description: The provided instances are randomly generated to test and validate optimization algorithms for the Operative Service Delivery Planning in the context of Product-Service Systems with focus on availability-based business models.
DOI: 10.17632/3p76z7n4vg.3
title: Problem Instances: Operative Service Delivery Planning in the Context of Product-Service Systems

description: The provided instances are randomly generated to test and validate optimization algorithms for the Operative Service Delivery Planning in the context of Product-Service Systems with focus on availability-based business models.
DOI: 10.6084/m9.figshare.23975580.v1
title: Supplementary Material for: MiR-320a acts as a tumor suppressor in somatotroph PitNETs by targeting BCAT1

description: Introduction: Aberrant miR-320a has been reported to be involved in the tumorigenesis of several cancers. In our previous study, we identified the low expression of circulating miR-320a in patients with somatotroph PitNET; however, the role of miR-320a in somatotroph PitNET proliferation is still unclear. Methods: Cell viability and colony formation assays were used to detect the effect of miR-320a and BCAT1 on GH3 cells. TargetScan was used to identify the target genes of miR-320a. Dual luciferase reporter gene assay was used to explore the relation between miR-320a and BCAT1. Transcriptome and proteome analyses were performed between somatotroph PitNETs and healthy controls. The expression level of miR-320a in somatotroph PitNETs were detected by RT‒qPCR and western blot. Results: miR-320a mimics inhibit cell proliferation, while miR-320a inhibitors promote cell proliferation in GH3 cells. An overlap analysis using a Venn diagram revealed that BCAT1 is the only target gene of miR-320a overexpressed in somatotroph PitNETs compared to healthy controls, as revealed by both microarray and proteomics results. A dual luciferase reporter gene assay showed that miR-320a may bind to the BCAT1-3'UTR. The transfection of miR-320a mimics downregulated the expression and miR-320a inhibitors and upregulated the expression of BCAT1 in GH3 cells. The interference of BCAT1 expression in GH3 cells downregulated cell proliferation and growth. Pan-cancer analyses demonstrated that high BCAT1 expression often indicates a poor prognosis. Conclusion: Our findings illustrate that miR-320a may function as a tumor suppressor and BCAT1 may promote tumor progression. miR-320a may inhibit the growth of somatotroph PitNETs by targeting BCAT1.
DOI: 10.17632/jdvjgp65hg.1
title: Progressive damage for 3D printed composites with variable fiber content and ply location

description: Data for 3D printed composites with variable fiber content and ply location
DOI: 10.6084/m9.figshare.24166554.v1
title: Supplementary Material for: Sterile corneal infiltrates following cataract surgery: case series.

description: We report a case series of twenty-six eyes of 26 patients undergoing planned cataract surgery from December 2021 to March 2022, who were diagnosed as having whitish round infiltrates in the surgical corneal incisions. The infiltrates were detected at the first check after 5 to 8 days from cataract surgery and were located either within the main corneal incision and/or in the smaller incisions. Corneal infiltrates (CIs) were single or multiple, without epithelial defects and painless. All infiltrates were initially treated with full topical antibiotic coverage, in order to control eventual and serious post-surgical infection. However, at daily checks, the clinical course of CIs suggested a sterile etiology. For this reason, steroidal topical treatment was maintained for a long time with slow tapering until complete remission of the CIs. All infiltrates resolved completely in around 30-40 days. The surgical instruments and the sterilization process were scrutinized. A white amorphous material was found mainly on non-disposable anterior chamber cannulas and on I/A tips. Disposable cannulas were adopted, and machinery for cleaning and sterilization procedures were reviewed, with specific reference to water softener renewal. Thanks to these precautions, CIs never occurred again. Finally, our hypothesis was an immune corneal reaction to amorphous deposit on cannula tips. This case series describes a previously unknown complication of cataract surgery and our experience might be useful for other surgeons.
DOI: 10.6084/m9.figshare.24032436.v1
title: Supplementary Material for: Pediatric Macrocorticotropinoma: Do They Differ from Microcorticotropinoma?

description: Introduction: Cushing’s disease (CD) due to macrocorticotropinoma (MC) in children and adolescents is a rare entity with limited information regarding its characteristics. The objective of the study is to describe the clinical, biochemical, imaging, management, outcome and genetic characteristics of children and adolescents with CD due to MC and compare them with those of microcorticotropinoma (mc). Methods: This retrospective study was conducted in a single tertiary care center. 32 patients of CD with MC (maximum tumor dimension ≥ 10 mm on imaging) and 65 patients with mc (&lt;10 mm on imaging) aged ≤20 years at presentation were enrolled. Results: Nineteen girls and 13 boys with MC presented at a median (IQR) age of 14.5 (12.0-17.9) years. Patients with MC had higher body mass index-standard deviation score (BMI-SDS) (3.70±2.60 vs 2.59±2.01, p=0.04), more frequent neuro-ophthalmic symptoms (25% vs 9% p=0.04) and short stature (59% vs 34%, p=0.049) but less frequent livid striae (53% vs 77%, p 0.01), and hypokalemia (12% vs 36%, p=0.04) and lower cortisol (nmol/l) to corticotropin (pmol/l) ratio (41.20 vs. 55.74, p=0.05) than those with mc. The remission (59% vs 64% p=1.0) and relapse (53% vs 37% p=0.26) rates after first-line surgery and remission rate after radiotherapy (RT) were comparable between the two cohorts whereas time to remission after RT (27 vs 13 months, p=0.05) was longer in the MC group. A patient with MC had a pathogenic germ line variant in CDH23. Conclusion: In this large monocentric series of pediatric CD, frequent mass effect symptoms and short stature, higher BMI-SDS, less frequent livid striae and hypokalemia with lower effective cortisol secretion characterize the MC cohort. The outcomes of surgery and RT were similar between the groups except for a longer time to remission after RT in the MC cohort.