cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30273785.v1
title: Evaluation of the diagnostic efficacy of different glycemic markers and insulin indices for diabetes mellitus in a general population

description: We aimed to assess the contribution of repeated fasting blood glucose (FBG) measurements along with single collection of 2-hour postprandial glucose (2h PG) and glycated hemoglobin (HbA1c) on diabetes mellitus (DM) prevalence estimation, and investigate the association between the insulin-related markers and DM risk in a southeastern Chinese population. We included 6515 participants aged 35–75 years with complete glycemic data. McNemar’s test was utilized to compare the difference between WHO and ADA criteria in DM diagnosis. Newly diagnosed DM cases were classified as 1defect (DEF), 2DEF, or 3DEF DM according to the abnormalities of three glycemic indices. The sensitivity and specificity of diagnosing DM using different glycemic markers were assessed. The association between different index and DM was analyzed using log-binomial regression and receiver operating characteristic curves. The age- and sex-standardized prevalence of DM was 14.0% and 14.7% by the WHO and ADA criteria, respectively. 2h PG, HbA1c, and FBG detected 89.65%, 40.69%, and 15.24% of newly diagnosed DM population, respectively. . All cases identified by repeated FBG were also detected by either 2h PG or HbA1c. The disposition index showed the highest area under the curve (0.82) in DM prediction, followed by the product of triglyceride and fasting glucose (TyG, 0.72). The estimated previous diagnosis, treatment, and control rate of DM was 38.6%, 34.9%, and 29.4%, respectively. It is recommended that 2h PG and HbA1c should be used in population-based studies. The disposition index and TyG could potentially be used as DM predictors. 2h PG plays a pivotal role in the identification of a substantial proportion of DM patients, while HbA1c can serve as an adjunctive tool to support the diagnosis.The disposition index and TyG can be used as potential predictor indicator for DM.The discrepancy between the WHO and ADA criteria was slight on the estimation of DM prevalence, but apparent on the estimation of prediabetes prevalence. 2h PG plays a pivotal role in the identification of a substantial proportion of DM patients, while HbA1c can serve as an adjunctive tool to support the diagnosis. The disposition index and TyG can be used as potential predictor indicator for DM. The discrepancy between the WHO and ADA criteria was slight on the estimation of DM prevalence, but apparent on the estimation of prediabetes prevalence.
DOI: 10.6084/m9.figshare.28925751
title: Differences of clinical features, prognosis and genetic mutations in Chinese patients with malignant melanoma and additional primary tumours

description: The differences in the clinical features, prognosis and genetic mutations in Chinese patients with malignant melanoma (MM) and additional primary tumours remain unclear. A retrospective analysis was conducted on patients with malignancies in Fujian Cancer Hospital from January 2007 to September 2022, end follow-up in September 2023. Clinical data were gathered, survival analysis was performed, and genetic mutations were detected. There were 58 of 1223 melanoma patients with melanoma and additional primary tumours, an incidence of 4.74%. Acral MM was the most common subtype (26/58), 23 (39.66%) patients had concomitant digestive tumours. Patients who had MM as their first primary tumour (MMFP) had shorter tumour occurrence intervals (9.93 vs. 57.78 months, <i>p</i> = .008) but longer melanoma survival (MM-OS) than the non-MMFP group (100.43 vs. 18.93 months, <i>p</i> = .015). Patients with cancer family histories were more likely to have pathogenic and likely pathogenic (P/LP) mutations (2/5 vs. 4/25). The somatic BRAF gene mutation was frequently observed in MM tissue (8/19, 42.11%). Three patients had whole-genome doubling and microsatellite instability-high (MSI-H). The COSMIC2 signature 3 was significantly higher in the P/LP group. The frequency of MM and additional primary tumours is about 5% in Chinese populations. Patients with melanoma diagnosed first have longer melanoma survival. Digestive system tumours were the most concomitant; a digestive examination is advisable, especially for those with an expected overall survival (OS) greater than 10 months. Meanwhile, patient’s family cancer history should be followed up in detail, along with completion of germline P/LP mutation and somatic mutation testing, all of which may provide valuable support for further treatment.
DOI: 10.6084/m9.figshare.28925751.v1
title: Differences of clinical features, prognosis and genetic mutations in Chinese patients with malignant melanoma and additional primary tumours

description: The differences in the clinical features, prognosis and genetic mutations in Chinese patients with malignant melanoma (MM) and additional primary tumours remain unclear. A retrospective analysis was conducted on patients with malignancies in Fujian Cancer Hospital from January 2007 to September 2022, end follow-up in September 2023. Clinical data were gathered, survival analysis was performed, and genetic mutations were detected. There were 58 of 1223 melanoma patients with melanoma and additional primary tumours, an incidence of 4.74%. Acral MM was the most common subtype (26/58), 23 (39.66%) patients had concomitant digestive tumours. Patients who had MM as their first primary tumour (MMFP) had shorter tumour occurrence intervals (9.93 vs. 57.78 months, <i>p</i> = .008) but longer melanoma survival (MM-OS) than the non-MMFP group (100.43 vs. 18.93 months, <i>p</i> = .015). Patients with cancer family histories were more likely to have pathogenic and likely pathogenic (P/LP) mutations (2/5 vs. 4/25). The somatic BRAF gene mutation was frequently observed in MM tissue (8/19, 42.11%). Three patients had whole-genome doubling and microsatellite instability-high (MSI-H). The COSMIC2 signature 3 was significantly higher in the P/LP group. The frequency of MM and additional primary tumours is about 5% in Chinese populations. Patients with melanoma diagnosed first have longer melanoma survival. Digestive system tumours were the most concomitant; a digestive examination is advisable, especially for those with an expected overall survival (OS) greater than 10 months. Meanwhile, patient’s family cancer history should be followed up in detail, along with completion of germline P/LP mutation and somatic mutation testing, all of which may provide valuable support for further treatment.
DOI: 10.6084/m9.figshare.29378157
title: Cross-sectional study of myopia prevalence and associated risk factors among children and adolescents in Shaanxi Province, China, in 2021

description: Myopia is a growing global health issue, particularly among Chinese children and adolescents. This study aimed to investigate the prevalence and risk factors of myopia among children and adolescents in Shaanxi Province, China. A cross-sectional study conducted in 2021 included 261,504 participants from Guanzhong, Southern Shaanxi, and Northern Shaanxi. Ophthalmological examinations were performed, and refractive error was assessed using non-cycloplegic refraction to determine the spherical equivalent (SE). Myopia was defined as SE ≤−0.5 D and categorized into low (SE &gt;−3.0 D), moderate (SE &gt;−6.0 D), and high myopia (SE ≤−6.0 D). Data on age, gender, education level, and ethnicity were collected using structured questionnaires administered through face-to-face interviews. The overall prevalence of myopia was 67.4% (95% CI: 67.20%–67.50%), with high myopia at 4.63% (95% CI: 4.55%–4.71%). Myopia was more common in females and increased with educational level, reaching 92.48% in senior high school students. Northern Shaanxi exhibited the highest prevalence of both myopia and high myopia. Regression analysis identified gender, education level, and region as significant risk factors. Myopia is highly prevalent among children and adolescents in Shaanxi Province, with notable gender, educational, and regional disparities. The findings underscore the urgent need for region-specific and education-level-targeted myopia prevention strategies.
DOI: 10.6084/m9.figshare.29378157.v1
title: Cross-sectional study of myopia prevalence and associated risk factors among children and adolescents in Shaanxi Province, China, in 2021

description: Myopia is a growing global health issue, particularly among Chinese children and adolescents. This study aimed to investigate the prevalence and risk factors of myopia among children and adolescents in Shaanxi Province, China. A cross-sectional study conducted in 2021 included 261,504 participants from Guanzhong, Southern Shaanxi, and Northern Shaanxi. Ophthalmological examinations were performed, and refractive error was assessed using non-cycloplegic refraction to determine the spherical equivalent (SE). Myopia was defined as SE ≤−0.5 D and categorized into low (SE &gt;−3.0 D), moderate (SE &gt;−6.0 D), and high myopia (SE ≤−6.0 D). Data on age, gender, education level, and ethnicity were collected using structured questionnaires administered through face-to-face interviews. The overall prevalence of myopia was 67.4% (95% CI: 67.20%–67.50%), with high myopia at 4.63% (95% CI: 4.55%–4.71%). Myopia was more common in females and increased with educational level, reaching 92.48% in senior high school students. Northern Shaanxi exhibited the highest prevalence of both myopia and high myopia. Regression analysis identified gender, education level, and region as significant risk factors. Myopia is highly prevalent among children and adolescents in Shaanxi Province, with notable gender, educational, and regional disparities. The findings underscore the urgent need for region-specific and education-level-targeted myopia prevention strategies.
DOI: 10.6084/m9.figshare.29874932
title: The efficacy and safety of pilates exercise in patients with knee osteoarthritis: a systematic review with meta-analysis of randomized controlled trials

description: Evidence on the effects of Pilates exercise in patients with knee osteoarthritis (KOA) remains limited. This meta-analysis aimed to evaluate its efficacy and safety. We searched PubMed, Web of Science, EMBASE, Cochrane Library, and Google Scholar up to May 21, 2024, for randomized controlled trials (RCTs). Outcomes included Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), knee range of motion (ROM), and adverse events. Risk of bias and evidence certainty were assessed; subgroup, sensitivity, and publication bias analyses were performed. Eight RCTs involving 322 participants were included. Risk of bias ranged from low to high, mainly due to lack of blinding. Compared to blank controls, Pilates significantly reduced WOMAC scores (SMD = −1.70; 95% CI: −3.14 to −0.25). One study comparing Pilates to health education reported significant reductions in VAS (MD = −1.74; 95% CI: −2.51 to −0.97) and WOMAC (SMD = −1.42; 95% CI: −2.39 to −0.45), but no significant ROM improvement. Compared to other exercises, Pilates showed no significant effects on VAS, WOMAC, or ROM. Funnel plots showed asymmetry for VAS and WOMAC; Egger’s test indicated possible publication bias (<i>p</i> = 0.0039 and 0.0154, respectively). No adverse events were reported, but active monitoring was limited. GRADE rated evidence as “very low” for VAS and WOMAC, and “low” for ROM. Pilates may relieve pain and improve physical function, but has limited effects on ROM. Due to insufficient adverse event reporting, safety remains unclear. Given the low study quality, high heterogeneity, and possible bias, results should be interpreted cautiously. Future studies should use standardized protocols, report long-term adherence, and assess mental health benefits.
DOI: 10.6084/m9.figshare.29874932.v1
title: The efficacy and safety of pilates exercise in patients with knee osteoarthritis: a systematic review with meta-analysis of randomized controlled trials

description: Evidence on the effects of Pilates exercise in patients with knee osteoarthritis (KOA) remains limited. This meta-analysis aimed to evaluate its efficacy and safety. We searched PubMed, Web of Science, EMBASE, Cochrane Library, and Google Scholar up to May 21, 2024, for randomized controlled trials (RCTs). Outcomes included Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), knee range of motion (ROM), and adverse events. Risk of bias and evidence certainty were assessed; subgroup, sensitivity, and publication bias analyses were performed. Eight RCTs involving 322 participants were included. Risk of bias ranged from low to high, mainly due to lack of blinding. Compared to blank controls, Pilates significantly reduced WOMAC scores (SMD = −1.70; 95% CI: −3.14 to −0.25). One study comparing Pilates to health education reported significant reductions in VAS (MD = −1.74; 95% CI: −2.51 to −0.97) and WOMAC (SMD = −1.42; 95% CI: −2.39 to −0.45), but no significant ROM improvement. Compared to other exercises, Pilates showed no significant effects on VAS, WOMAC, or ROM. Funnel plots showed asymmetry for VAS and WOMAC; Egger’s test indicated possible publication bias (<i>p</i> = 0.0039 and 0.0154, respectively). No adverse events were reported, but active monitoring was limited. GRADE rated evidence as “very low” for VAS and WOMAC, and “low” for ROM. Pilates may relieve pain and improve physical function, but has limited effects on ROM. Due to insufficient adverse event reporting, safety remains unclear. Given the low study quality, high heterogeneity, and possible bias, results should be interpreted cautiously. Future studies should use standardized protocols, report long-term adherence, and assess mental health benefits.
DOI: 10.15468/dl.mjab57
title: Occurrence Download

description: A dataset containing 65 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-120.76795 37.65856,-119.73315 37.66314,-119.79725 38.63841,-120.67637 38.64986,-120.76795 37.65856))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Actinemys marmorata"
 ]
}

 The dataset includes 65 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003101-260120142942310/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30540796
title: Global, regional, and national burden and trends of mental disorders in women of childbearing age: a systematic analysis based on the global burden of disease study 2021

description: This study aims to provide a comprehensive picture of mental disorder burden in women of childbearing age (WCBA), providing scientific evidence for implementing disease prevention and control strategies. Based on the data from the Global Burden of Disease study 2021, the age-standardized prevalence rates (ASPR) and disability-adjusted life years (DALY) rates (ASDR) of mental disorders in WCBA, along with their temporal trends, age-period-cohort effects and projection of epidemiological trajectory over the next 10 years were comprehensively analyzed. In 2021, there were an estimated 343.22 million mental disorder cases in WCBA, with a global ASPR of 17573.61 per 100,000 population and ASDR of 2696.58 per 100,000 population worldwide. Anxiety disorders accounted for the highest prevalence proportion (37.49%), while depressive disorders were the leading DALYs contributors (39.91%) in mental disorders. From 1990 to 2021, the global mental disorder burden showed significant upward trends, with ASPR and ASDR rising at annual average percent changes (AAPC) of 0.35 and 0.38 respectively. The deterioration was more pronounced in anxiety disorders (AAPC 0.74 and 0.73), eating disorders (AAPC 0.42 and 0.41) and depressive disorders (AAPC 0.39 and 0.45). The APC analysis indicated that the disease burden gradually increased with age, and the relative risk peaked during the period of 2017–2021. The projections suggest that the global burden of mental disorders will persistently rise from 2022 to 2031 in WCBA. Specifically, the ASPR and ASDR are projected to reach 23872.35 per 100,000 population and 3570.07 per 100,000 population in 2031, respectively. The global burden of mental disorders is particularly severe in WCBA and still on the rise. Innovative prevention and healthcare strategies are urgently needed to reduce the burden of highly prevalent, rapidly increasing diseases in high-risk areas. This study fills a research blank by presenting a comprehensive global, regional and national perspective on the burden, trends and prediction of mental disorders in WCBA from 1990 to 2021.The global burden of mental disorders in WCBA is alarmingly high and continues to rise at an accelerating rate.Urgent implementation of innovative preventive and healthcare strategies is needed to mitigate the burden, especially for disease subtypes with high prevalence or rapid growth, and for regions identified as being at high risk. This study fills a research blank by presenting a comprehensive global, regional and national perspective on the burden, trends and prediction of mental disorders in WCBA from 1990 to 2021. The global burden of mental disorders in WCBA is alarmingly high and continues to rise at an accelerating rate. Urgent implementation of innovative preventive and healthcare strategies is needed to mitigate the burden, especially for disease subtypes with high prevalence or rapid growth, and for regions identified as being at high risk.
DOI: 10.6084/m9.figshare.29959167
title: Diagnosis, treatment and clinical outcomes of extrauterine sites of leiomyomatosis: a systematic review

description: This review aims to provide a comprehensive description of the clinical presentation, treatment, and histopathological features of extrauterine sites of leiomyomatosis (ESL), such as disseminated peritoneal leiomyomatosis (DPL), parasitic myoma (PM), benign metastatic leiomyoma (BML), and intravascular leiomyoma (IVL). The impact of previous surgery (hysterectomy or myomectomy) on development of intra-abdominal extrauterine leiomyomas (IAELs) and extra-abdominal extrauterine leiomyomas (EAELs) has been evaluated. According to PRISMA guidelines, we searched PubMed, Scopus, and Web of Science databases. Relevant articles were retrieved in full-text format and screened based on predefined inclusion and exclusion criteria. 358 studies (372 cases) are included. Among IAELs, the most common symptom is abdominopelvic pain (63.9% of DPL, and 69.2% of PMs cases, respectively). In contrast, EAELs exhibit heterogeneous clinical presentations; dyspnea is the most common symptom (29.7% of BML, and 29.9% of IVL cases, respectively). 68.8% of DPL, 60% of PM, 89.7% of BML, and 56.4% of IVL patients underwent previous uterine surgery. A significant association (<i>p</i> = 0.0417) between the type of previous uterine surgery (hysterectomy and myomectomy) and the subsequent location of ESLs is found (68.7% VS 51.4% in EAELs, 31.3% VS 48.6% in IAELs, respectively). DPL, PM, BML, and IVL exhibit overlapping characteristics, requiring a multimodal approach that includes imaging, histopathology, and surgical or medical management. Greater awareness among clinicians is needed regarding surgical procedures involving ligation and/or cutting of major uterine vessels, which appear to contribute to the development of EAELs, and morcellation, which tends to promote intraperitoneal metastatic spread. Disseminated peritoneal leiomyomatosis, parasitic myoma, benign metastatic leiomyoma, and intravascular leiomyoma represent a continuum of extrauterine sites of leiomyomatosis with overlapping but distinct features, requiring careful diagnostic differentiation.While surgical excision remains the mainstay, an integrated approach including imaging, histopathology, and medical-surgical management is essential for optimal patient outcomes. Disseminated peritoneal leiomyomatosis, parasitic myoma, benign metastatic leiomyoma, and intravascular leiomyoma represent a continuum of extrauterine sites of leiomyomatosis with overlapping but distinct features, requiring careful diagnostic differentiation. While surgical excision remains the mainstay, an integrated approach including imaging, histopathology, and medical-surgical management is essential for optimal patient outcomes.
DOI: 10.6084/m9.figshare.29959167.v1
title: Diagnosis, treatment and clinical outcomes of extrauterine sites of leiomyomatosis: a systematic review

description: This review aims to provide a comprehensive description of the clinical presentation, treatment, and histopathological features of extrauterine sites of leiomyomatosis (ESL), such as disseminated peritoneal leiomyomatosis (DPL), parasitic myoma (PM), benign metastatic leiomyoma (BML), and intravascular leiomyoma (IVL). The impact of previous surgery (hysterectomy or myomectomy) on development of intra-abdominal extrauterine leiomyomas (IAELs) and extra-abdominal extrauterine leiomyomas (EAELs) has been evaluated. According to PRISMA guidelines, we searched PubMed, Scopus, and Web of Science databases. Relevant articles were retrieved in full-text format and screened based on predefined inclusion and exclusion criteria. 358 studies (372 cases) are included. Among IAELs, the most common symptom is abdominopelvic pain (63.9% of DPL, and 69.2% of PMs cases, respectively). In contrast, EAELs exhibit heterogeneous clinical presentations; dyspnea is the most common symptom (29.7% of BML, and 29.9% of IVL cases, respectively). 68.8% of DPL, 60% of PM, 89.7% of BML, and 56.4% of IVL patients underwent previous uterine surgery. A significant association (<i>p</i> = 0.0417) between the type of previous uterine surgery (hysterectomy and myomectomy) and the subsequent location of ESLs is found (68.7% VS 51.4% in EAELs, 31.3% VS 48.6% in IAELs, respectively). DPL, PM, BML, and IVL exhibit overlapping characteristics, requiring a multimodal approach that includes imaging, histopathology, and surgical or medical management. Greater awareness among clinicians is needed regarding surgical procedures involving ligation and/or cutting of major uterine vessels, which appear to contribute to the development of EAELs, and morcellation, which tends to promote intraperitoneal metastatic spread. Disseminated peritoneal leiomyomatosis, parasitic myoma, benign metastatic leiomyoma, and intravascular leiomyoma represent a continuum of extrauterine sites of leiomyomatosis with overlapping but distinct features, requiring careful diagnostic differentiation.While surgical excision remains the mainstay, an integrated approach including imaging, histopathology, and medical-surgical management is essential for optimal patient outcomes. Disseminated peritoneal leiomyomatosis, parasitic myoma, benign metastatic leiomyoma, and intravascular leiomyoma represent a continuum of extrauterine sites of leiomyomatosis with overlapping but distinct features, requiring careful diagnostic differentiation. While surgical excision remains the mainstay, an integrated approach including imaging, histopathology, and medical-surgical management is essential for optimal patient outcomes.