cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/134585
title: Expendable Probe data collected during research cruise SR1913 using a Turo Quoll instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134587
title: GNSS (Global Navigation Satellite System) data collected during research cruise SR1913 using a Trimble BD982 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134591
title: INS (Inertial Navigation System) data collected during research cruise SR1913 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134598
title: INS (Inertial Navigation System) data collected during research cruise SR1913 using a iXSea Hydrins instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134599
title: INS (Inertial Navigation System) data collected during research cruise SR1913 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134600
title: INS (Inertial Navigation System) data collected during research cruise SR1913 using a iXSea Hydrins instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134582
title: Meteorological Station data collected during research cruise SR1913 using a SIO MET-System instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134589
title: Multibeam Echosounder data collected during research cruise SR1913 using a Kongsberg EM122 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134584
title: Singlebeam Echosounder data collected during research cruise SR1913 using a Knudsen 3260 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134594
title: Winch data collected during research cruise SR1913 using a Markey DETW-9-11 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134595
title: Winch data collected during research cruise SR1913 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134596
title: Winch data collected during research cruise SR1913 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134550
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SR1914 using a Hawaii UHDAS instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134545
title: Expendable Probe data collected during research cruise SR1914 using a Turo Quoll instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134547
title: GNSS (Global Navigation Satellite System) data collected during research cruise SR1914 using a Trimble BD982 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134551
title: INS (Inertial Navigation System) data collected during research cruise SR1914 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195103
title: Supplementary Material for: Comparative Transcriptomic Analysis of Embryo Implantation in Mice and Rats

description: <b><i>Background/Aims:</i></b> Embryo implantation is an essential process for eutherian pregnancy, but this process varies across eutherians. The genomic mechanisms that led to the emergence and diversification of embryo implantation are largely unknown. <b><i>Methods:</i></b> In this study, we analyzed transcriptomic changes during embryo implantation in mice and rats by using RNA-seq. Bioinformatics and evolutionary analyses were performed to characterize implantation-associated genes in these two species. <b><i>Results:</i></b> We identified a total of 518 differentially expressed genes in mouse uterus during implantation, of which 253 genes were up-regulated and 265 genes were down-regulated at the implantation sites compared with the inter-implantation sites. In rat uterus, there were 374 differentially expressed genes, of which 284 genes were up-regulated and 90 genes were down-regulated. A cross-species comparison revealed that 92 up-regulated genes and 20 down-regulated genes were shared. The differences and similarities between mice and rats were investigated further at the gene ontology, pathway, network, and causal transcription factor levels. Additionally, we found that embryo implantation might have evolved through the recruitment of ancient genes into uterine expression. The evolutionary rates of the differentially expressed genes in mouse and rat uterus were significantly lower than those of the non-changed genes, indicating that implantation-related genes are evolutionary conserved due to high selection pressure. <b><i>Conclusion:</i></b> Our study provides insights into the molecular mechanisms involved in the evolution of embryo implantation.
DOI: 10.6084/m9.figshare.7195100
title: Trusting nudges? Lessons from an international survey

description: In the past decade, policymakers have increasingly used behaviourally informed policies, including ‘nudges,’ to produce desirable social outcomes. But do people actually endorse those policies? This study reports on nationally representative surveys in five countries (Belgium, Denmark, Germany, South Korea, and the US) carried out in 2017/2018. We investigate whether people in these countries approve of a list of 15 nudges regarding health, the environment, and safety issues. A particular focus is whether trust in public institutions is a potential mediator of approval. The study confirms this correlation. We also find strong majority support of all nudges in the five countries. Our findings in general, and about trust in particular, suggest the importance not only of ensuring that behaviourally informed policies are effective, but also of developing them transparently and openly, and with an opportunity for members of the public to engage and to express their concerns.
DOI: 10.7284/134559
title: INS (Inertial Navigation System) data collected during research cruise SR1914 using a iXSea Hydrins instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195100.v1
title: Trusting nudges? Lessons from an international survey

description: In the past decade, policymakers have increasingly used behaviourally informed policies, including ‘nudges,’ to produce desirable social outcomes. But do people actually endorse those policies? This study reports on nationally representative surveys in five countries (Belgium, Denmark, Germany, South Korea, and the US) carried out in 2017/2018. We investigate whether people in these countries approve of a list of 15 nudges regarding health, the environment, and safety issues. A particular focus is whether trust in public institutions is a potential mediator of approval. The study confirms this correlation. We also find strong majority support of all nudges in the five countries. Our findings in general, and about trust in particular, suggest the importance not only of ensuring that behaviourally informed policies are effective, but also of developing them transparently and openly, and with an opportunity for members of the public to engage and to express their concerns.
DOI: 10.6084/m9.figshare.7195097
title: Schimmel et al 2018 International Journal of Molecular Sciences raw data

description: Raw data (phytohormones and qPCR) belonging to the manuscript entitled "Distinct signatures of host defense suppression by plant-feeding mites" by Schimmel et al. 2018
DOI: 10.6084/m9.figshare.7195097.v1
title: Schimmel et al 2018 International Journal of Molecular Sciences raw data

description: Raw data (phytohormones and qPCR) belonging to the manuscript entitled "Distinct signatures of host defense suppression by plant-feeding mites" by Schimmel et al. 2018
DOI: 10.7284/134560
title: INS (Inertial Navigation System) data collected during research cruise SR1914 using a Kongsberg Seapath 330+ instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134561
title: INS (Inertial Navigation System) data collected during research cruise SR1914 using a iXSea Hydrins instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195067
title: Supplementary Material for: Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin

description: <b><i>Background/Aims:</i></b> Acute respiratory tract infection (ARTI) is the most common reason for outpatient physician office visits. Although powerful and significant in the treatment of infections, antibiotics used for ARTI inappropriately have been an important contributor to antibiotic resistance. We previously reported that Shufeng Jiedu Capsule (SJC) can effectively amplify anti-inflammatory signaling during infection. In this study, we aimed to systematically explore its composition and the mechanism of its effects in ARTI. <b><i>Methods:</i></b> <i>Pseudomonas aeruginosa</i> (PAK) strain was used to generate a mouse model of ARTI, which were then treated with different drugs or compounds to determine the corresponding anti-inflammatory roles. High-performance liquid chromatography-quadrupole time of flight-tandem mass spectrometry. was conducted to detect the chemical compounds in SJC. RNAs from the lung tissues of mice were prepared for microarray analysis to reveal globally altered genes and the pathways involved after SJC treatment. <b><i>Results:</i></b> SJC significantly inhibited the expression and secretion of inflammatory factors from PAK-induced mouse lung tissues or lipopolysaccharide-induced peritoneal macrophages. Verbenalin, one of the bioactive compounds identified in SJC, also showed notable anti-inflammatory effects. Microarray data revealed numerous differentially expressed genes among the different treatment groups; here, we focused on studying the role of GPR18. We found that the anti-inflammatory role of verbenalin was attenuated in GPR18 knockout mice compared with wild-type mice, although no statistically significant difference was observed in the untreated PAK-induced mice types. <b><i>Conclusion:</i></b> Our data not only showed the chemical composition of SJC, but also demonstrated that verbenalin was a significant anti-inflammatory compound, which may function through GPR18.
DOI: 10.7284/134543
title: Meteorological Station data collected during research cruise SR1914 using a SIO MET-System instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195055
title: Seradina I R. 12 - Catalogo iconografico sintetico

description: Catalogo generale per categoria e sotto-categoria delle figure presenti sulla R. 12 di Seradina I (Valcamonica, BS) come pubblicato in Marretta, A. (2018). <i>La Roccia 12 di Seradina I: documentazione, analisi e interpretazione di un capolavoro dell’arte rupestre alpina</i>. Capo di Ponte: Edizioni del Parco di Seradina-Bedolina, p. 74.
DOI: 10.6084/m9.figshare.7195055.v1
title: Seradina I R. 12 - Catalogo iconografico sintetico

description: Catalogo generale per categoria e sotto-categoria delle figure presenti sulla R. 12 di Seradina I (Valcamonica, BS) come pubblicato in Marretta, A. (2018). <i>La Roccia 12 di Seradina I: documentazione, analisi e interpretazione di un capolavoro dell’arte rupestre alpina</i>. Capo di Ponte: Edizioni del Parco di Seradina-Bedolina, p. 74.
DOI: 10.6084/m9.figshare.7195040
title: Supplementary Material for: Generation of a Urine-Derived Ips Cell Line from a Patient with a Ventricular Septal Defect and Heart Failure and the Robust Differentiation of These Cells to Cardiomyocytes via Small Molecules

description: <b><i>Background/Aims:</i></b> Ventricular septal defects (VSDs) are one of the most common types of congenital heart malformations. Volume overload resulting from large VSDs can lead to heart failure (HF) and constitutes a major cause of pediatric HF with a series of often-fatal consequences. The etiology of VSD with HF is complex, and increasing evidence points toward a genetic basis. Indeed, we identified an L2483R mutation in the ryanodine receptor type 2 (RyR2) in a 2-month-old male patient with VSD with HF. <b><i>Methods:</i></b> We generated integration-free induced pluripotent stem cells from urine samples (UiPSCs) of this patient using Sendai virus containing the Yamanaka factors and characterized these cells based on alkaline phosphatase activity, pluripotency marker expression, and teratoma formation. Then, we induced the derived UiPSCs to rapidly and efficiently differentiate into functional cardiomyocytes through temporal modulation of canonical Wnt signaling with small molecules. Real-time PCR and immunofluorescence were used to verify the expression of myocardium-specific markers in the differentiated cardiomyocytes. The ultrastructure of the derived myocardial cells was further analyzed by using transmission electron microscopy. <b><i>Results:</i></b> The established UiPSC lines were positive for alkaline phosphatase activity, retained the RyR2 mutation, expressed pluripotency markers, and displayed differentiation potential to three germ layers <i>in vivo</i>. The UiPSC-derived cells showed hallmarks of cardiomyocytes, including spontaneous contraction and strong expression of cardiac-specific proteins and genes. However, compared with cardiomyocytes derived from H9 cells, they had a higher level of autophagy, implying that autophagy may play an important role in the development of VSD with HF. <b><i>Conclusion:</i></b> The protocol described here yields abundant myocardial cells and provides a solid platform for further investigation of the pathogenesis, pharmacotherapy, and gene therapy of VSD with HF.
DOI: 10.7284/134548
title: Multibeam Echosounder data collected during research cruise SR1914 using a Kongsberg EM712 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195040.v1
title: Supplementary Material for: Generation of a Urine-Derived Ips Cell Line from a Patient with a Ventricular Septal Defect and Heart Failure and the Robust Differentiation of These Cells to Cardiomyocytes via Small Molecules

description: <b><i>Background/Aims:</i></b> Ventricular septal defects (VSDs) are one of the most common types of congenital heart malformations. Volume overload resulting from large VSDs can lead to heart failure (HF) and constitutes a major cause of pediatric HF with a series of often-fatal consequences. The etiology of VSD with HF is complex, and increasing evidence points toward a genetic basis. Indeed, we identified an L2483R mutation in the ryanodine receptor type 2 (RyR2) in a 2-month-old male patient with VSD with HF. <b><i>Methods:</i></b> We generated integration-free induced pluripotent stem cells from urine samples (UiPSCs) of this patient using Sendai virus containing the Yamanaka factors and characterized these cells based on alkaline phosphatase activity, pluripotency marker expression, and teratoma formation. Then, we induced the derived UiPSCs to rapidly and efficiently differentiate into functional cardiomyocytes through temporal modulation of canonical Wnt signaling with small molecules. Real-time PCR and immunofluorescence were used to verify the expression of myocardium-specific markers in the differentiated cardiomyocytes. The ultrastructure of the derived myocardial cells was further analyzed by using transmission electron microscopy. <b><i>Results:</i></b> The established UiPSC lines were positive for alkaline phosphatase activity, retained the RyR2 mutation, expressed pluripotency markers, and displayed differentiation potential to three germ layers <i>in vivo</i>. The UiPSC-derived cells showed hallmarks of cardiomyocytes, including spontaneous contraction and strong expression of cardiac-specific proteins and genes. However, compared with cardiomyocytes derived from H9 cells, they had a higher level of autophagy, implying that autophagy may play an important role in the development of VSD with HF. <b><i>Conclusion:</i></b> The protocol described here yields abundant myocardial cells and provides a solid platform for further investigation of the pathogenesis, pharmacotherapy, and gene therapy of VSD with HF.
DOI: 10.7284/134549
title: Multibeam Echosounder data collected during research cruise SR1914 using a Kongsberg EM122 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195019
title: Supplementary Material for: Comprehensive Analysis of Differentially Expressed Profiles of lncRNAs/mRNAs and miRNAs with Associated ceRNA Networks in Triple-Negative Breast Cancer

description: <b><i>Background/Aims:</i></b> Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. Growing evidence indicates that Long noncoding RNAs (lncRNAs) play important regulatory roles in the development and progression of a variety of cancers including breast cancer. However, the underlying mechanisms remain largely unknown. <b><i>Methods:</i></b> Here, we compared the expression profiles of mRNAs, lncRNAs and miRNAs between 111 TNBC tissues and 104 non-cancerous tissues utilizing RNA-Seq Data from The Cancer Genome Atlas (TCGA). Gene Ontology and KEGG pathway enrichment analyses were executed to investigate the principal functions of the significantly dysregulated mRNAs. Moreover, Kaplan-Meier survival analyses were performed to determine the effects of differentially expressed lncRNAs/mRNAs/miRNAs on overall survival. Subsequently, we constructed a competing endogenous RNA (ceRNA) network, which included 66 dysregulated lncRNAs, 24 miRNAs and 55 mRNAs. The four dysregulated lncRNAs, three aberrantly expressed miRNAs and four mRNAs were confirmed in the ceRNA network by qRT-PCR in 30 pairs of samples, respectively. <b><i>Results:</i></b> A total of 1441 lncRNAs, 114 miRNA and 2501 mRNAs were found to be differentially expressed in TNBC tissues compared with controls. 109 lncRNAs and 124 mRNAs might serve as prognostic signature for patients with TNBC according to the survival analysis. Functional analysis revealed that 19 mRNAs in the ceRNA network were enriched in 17 cancer-related pathways. <b><i>Conclusion:</i></b> Taken together, we identified novel lncRNAs/miRNAs which may serve as potential biomarkers to predict the survival and therapeutic targets for TNBC patients based on a large-scale sample. More importantly, we constructed the ceRNA network of TNBC, which provides valuable information to further explore the molecular mechanism underlying tumorigenesis and development of TNBC.
DOI: 10.7284/134555
title: Winch data collected during research cruise SR1914 using a Markey DETW-9-11 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7195019.v1
title: Supplementary Material for: Comprehensive Analysis of Differentially Expressed Profiles of lncRNAs/mRNAs and miRNAs with Associated ceRNA Networks in Triple-Negative Breast Cancer

description: <b><i>Background/Aims:</i></b> Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. Growing evidence indicates that Long noncoding RNAs (lncRNAs) play important regulatory roles in the development and progression of a variety of cancers including breast cancer. However, the underlying mechanisms remain largely unknown. <b><i>Methods:</i></b> Here, we compared the expression profiles of mRNAs, lncRNAs and miRNAs between 111 TNBC tissues and 104 non-cancerous tissues utilizing RNA-Seq Data from The Cancer Genome Atlas (TCGA). Gene Ontology and KEGG pathway enrichment analyses were executed to investigate the principal functions of the significantly dysregulated mRNAs. Moreover, Kaplan-Meier survival analyses were performed to determine the effects of differentially expressed lncRNAs/mRNAs/miRNAs on overall survival. Subsequently, we constructed a competing endogenous RNA (ceRNA) network, which included 66 dysregulated lncRNAs, 24 miRNAs and 55 mRNAs. The four dysregulated lncRNAs, three aberrantly expressed miRNAs and four mRNAs were confirmed in the ceRNA network by qRT-PCR in 30 pairs of samples, respectively. <b><i>Results:</i></b> A total of 1441 lncRNAs, 114 miRNA and 2501 mRNAs were found to be differentially expressed in TNBC tissues compared with controls. 109 lncRNAs and 124 mRNAs might serve as prognostic signature for patients with TNBC according to the survival analysis. Functional analysis revealed that 19 mRNAs in the ceRNA network were enriched in 17 cancer-related pathways. <b><i>Conclusion:</i></b> Taken together, we identified novel lncRNAs/miRNAs which may serve as potential biomarkers to predict the survival and therapeutic targets for TNBC patients based on a large-scale sample. More importantly, we constructed the ceRNA network of TNBC, which provides valuable information to further explore the molecular mechanism underlying tumorigenesis and development of TNBC.
DOI: 10.7284/134556
title: Winch data collected during research cruise SR1914 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134557
title: Winch data collected during research cruise SR1914 using a Markey CAST-6-125 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134569
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SR1916 using a Hawaii UHDAS instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7194998
title: Data Supplementary Materials from Seasonally sympatric but allochronic: differential expression of hypothalamic genes in a songbird during gonadal development

description: Data that will be published by Dryad if manuscript is selected for publication
DOI: 10.6084/m9.figshare.7194998.v1
title: Data Supplementary Materials from Seasonally sympatric but allochronic: differential expression of hypothalamic genes in a songbird during gonadal development

description: Data that will be published by Dryad if manuscript is selected for publication
DOI: 10.7284/134564
title: Expendable Probe data collected during research cruise SR1916 using a Turo Quoll instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/134566
title: GNSS (Global Navigation Satellite System) data collected during research cruise SR1916 using a Trimble BD982 instrument system onboard the platform RV Sally Ride

description: Original (unprocessed) data collected during a Field_expedition