cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19962745.v1
title: Radiotherapy-induced bone deterioration is exacerbated in diabetic rats treated with streptozotocin

description: Following radiotherapy, patients have decreased bone mass and increased risk of fragility fractures. Diabetes mellitus (DM) is also reported to have detrimental effects on bone architecture and quality. However, no clinical or experimental study has systematically characterized the bone phenotype of the diabetic patients following radiotherapy. After one month of streptozotocin injection, three-month-old male rats were subjected to focal radiotherapy (8 Gy, twice, at days 1 and 3), and then bone mass, microarchitecture, and turnover as well as bone cell activities were evaluated at 2 months post-irradiation. Micro-computed tomography results demonstrated that DM rats exhibited greater deterioration in trabecular bone mass and microarchitecture following irradiation compared with the damage to bone structure induced by DM or radiotherapy. The serum biochemical, bone histomorphometric, and gene expression assays revealed that DM combined with radiotherapy showed lower bone formation rate, osteoblast number on bone surface, and expression of osteoblast-related markers (ALP, Runx2, Osx, and Col-1) compared with DM or irradiation alone. DM plus irradiation also caused higher bone resorption rate, osteoclast number on bone surface, and expression of osteoclast-specific markers (TRAP, cathepsin K, and calcitonin receptor) than DM or irradiation treatment alone. Moreover, lower osteocyte survival and higher expression of Sost and DKK1 genes (two negative modulators of Wnt signaling) were observed in rats with combined DM and radiotherapy. Together, these findings revealed a higher deterioration of the diabetic skeleton following radiotherapy, and emphasized the clinical importance of health maintenance.
DOI: 10.6084/m9.figshare.19962784.v1
title: Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function

description: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly. The aim of this study was to explore the effects of AD on cardiac function and autonomic nervous function, and the feasibility of electrocardiogram (ECG) in monitoring the development of AD. APP/PS1 double transgenic mice were used in the Morris water maze (MWM) experiment to evaluate the changes of cognitive ability of AD mice, then the non-invasive ECG acquisition system was used and the changes of ECG intervals and heart rate variability (HRV) were analyzed. AD mice already had cognitive dysfunction at the age of 5 months, reaching the level of mild dementia, and the degree of dementia increased with the course of disease. There were no significant changes in ECG intervals in the AD group at each month. The mean square of successive RR interval differences, percentage of intervals &gt;6 ms different from preceding interval, and normalized high frequency power component in the AD group were decreased and low-to-high frequency power ratio and normalized low frequency power component were increased. Combined with the results of the MWM, it was shown that the regulation mechanism of sympathetic and parasympathetic nerves in mice was already imbalanced in early stage AD, which was manifested as the increase of excessive activity of sympathetic nerves and the inhibition of parasympathetic activities. Therefore, ECG-based analysis of HRV may become a means of daily monitoring of AD and provide an auxiliary basis for clinical diagnosis.
DOI: 10.6084/m9.figshare.19962729
title: Caveolin-1 promotes tumor cell proliferation and vasculogenic mimicry formation in human glioma

description: Vasculogenic mimicry (VM) plays an important role in human glioma progression and resistance to antiangiogenic therapy as a compensatory neovascularization mechanism in malignant tumors. Caveolin-1 (Cav-1) has been found to contribute to VM formation. However, it remains largely unknown whether Cav-1 expression correlates with VM in glioma. In this study, we examined CAV-1 expression levels and VM in human glioma cell lines and in 94 human gliomas with different grades of malignancy, and present Cox proportional hazards regression. The molecular role of Cav-1 in glioma cells was investigated using quantitative polymerase chain reaction (qRT-PCR) assays, western blotting, CCK-8 assays, and tubule formation assays. Cav-1 expression and VM formation were positively correlated with each other and both were closely associated with glioma development and progression as evidenced by the presence of cystic tumor, shortened survival time, and advanced-stage glioma in glioma patients with Cav-1 overexpression/increased VM formation. Cav-1 promoted U251 glioma cell proliferation and VM formation in a Matrigel-based 3D culture model. VM-associated factors including hypoxia-inducible factor 1α (HIF-1α) and p-Akt was significantly elevated by Cav-1 overexpression but suppressed by siCav-1 in U251 cells. Collectively, our study identified Cav-1 as an important regulator of glioma cell proliferation and VM formation, contributing to glioma development and progression.
DOI: 10.6084/m9.figshare.19962816
title: The LDL/HDL ratio predicts long-term risk of coronary revascularization in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: a cohort study

description: Clinical indicators do not adequately predict the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio is expected to be a reliable predictor of the long-term prognosis of these patients. This study aimed to explore the correlation between the LDL/HDL ratio and long-term prognosis in STEMI patients undergoing PCI. Patients with confirmed STEMI who underwent PCI in 7 hospitals in China from January 2009 to December 2011 were enrolled. Information about clinical endpoints, including all-cause death and major adverse cardiovascular events, was collected. Overall, 915 patients were included for analysis, the average follow-up time was 112.2 months. According to the LDL/HDL ratio, the patients were divided into 3 groups using the three-quantile method: low (LDL/HDL≤1.963), medium (1.963
DOI: 10.5281/zenodo.10624743
title: Chelmon_rostratus_EPLATE_40_H10_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.5281/zenodo.10624744
title: Chelmon_rostratus_EPLATE_40_H10_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.6084/m9.figshare.10001564.v1
title: MOESM11 of Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression

description: Additional file 11. CircRNAs from RNA sequencing targeted miRNAs.
DOI: 10.6084/m9.figshare.23632659
title: Additional file 3 of Growth hormone treatment improves the development of follicles and oocytes in prepubertal lambs

description: Additional file 3. DMs in follicular fluid metabolome between control and GH treatment groups.
DOI: 10.5281/zenodo.10624759
title: craterocephalus_eyresii_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.5281/zenodo.10624760
title: craterocephalus_eyresii_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.6084/m9.figshare.10001729.v1
title: MOESM10 of Genome-wide identification and characterization of TALE superfamily genes in cotton reveals their functions in regulating secondary cell wall biosynthesis

description: Additional file 10: Table S7. Primer sequences were used in this study.
DOI: 10.6084/m9.figshare.13669546.v1
title: Additional file 5 of Degradome sequencing-based identification of phasiRNAs biogenesis pathways in Oryza sativa

description: Additional file 5: Table S3. Datasets utilized for our study.
DOI: 10.6084/m9.figshare.10002098.v2
title: Perron from The interdependence of corporate reputation and ownership: a network approach to quantify reputation.

description: perron.m is the function file to calculate eigen value.
DOI: 10.6084/m9.figshare.5807361
title: To Wait or Not to Wait: Two-Way Functional Hazards Model for Understanding Waiting in Call Centers

description: Telephone call centers offer a convenient communication channel between businesses and their customers. Efficient management of call centers needs accurate modeling of customer waiting behavior, which contains important information about customer patience (how long a customer is willing to wait) and service quality (how long a customer needs to wait to get served). Hazard functions offer dynamic characterization of customer waiting behavior, and provide critical inputs for agent scheduling. Motivated by this application, we develop a two-way functional hazards (tF-Hazards) model to study customer waiting behavior as a function of two timescales, waiting duration and the time of day that a customer calls in. The model stems from a two-way piecewise constant hazard function, and imposes low-rank structure and smoothness on the hazard rates to enhance interpretability. We exploit an alternating direction method of multipliers algorithm to optimize a penalized likelihood function of the model. We carefully analyze the data from a U.S. Bank call center, and provide informative insights about customer patience and service quality patterns along waiting time and across different times of a day. The findings provide primitive inputs for call center agent staffing and scheduling, as well as for call center practitioners to understand the effect of system protocols on customer waiting behavior. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.10002110
title: ownership network.txt from The interdependence of corporate reputation and ownership: a network approach to quantify reputation.

description: This file describes the ownership network used in the paper. Each line i,j,w denotes the ownership between firm i and firm j with weight w.
DOI: 10.6084/m9.figshare.13671755.v2
title: An epithelial-mesenchymal transition-related long non-coding RNA signature to predict overall survival and immune microenvironment in kidney renal clear cell carcinoma

description: Kidney renal clear cell carcinoma (ccRCC) is a malignant tumor originating from renal tubular epithelium, lncRNAs can regulate the occurrence and development of EMT by targeting EMT transcription factors. We constructed a new survival signature based on EMT-related differentially expressed lncRNAs obtained from the Cancer Genome Atlas (TCGA-KIRC). We first determined 1377 EMT-related lncRNAs, lncRNA AL035661.1 with the largest correlation coefficient and the target gene was <i>PFN2</i> (cor = 0.843; <i>P</i>= 1.37E-146). Meanwhile, we found an AUC of 0.758 in our signature and we predicted the AUC values of the patients’ 1, 2, 3-year survival rate as 0.768, 0.749, and 0.762 in TCGA cohort, respectively. Multivariate COX analysis was performed to determine if risk score was an independent prognostic predictor of OS. The results indicated that our risk score can be an independent predictor for OS (Univariate: HR = 1.350, 95% CI = 1.276–1.428, <i>P</i>&lt; 0.001; Multivariate: HR = 1.295, 95% CI = 1.201–1.396, <i>P</i>&lt; 0.001). We identified novel EMT-related lncRNAs markers for ccRCC prognosis. The underlying mechanism between EMT-related lncRNAs in ccRCC and tumor immunity is still unclear and requires further study.
DOI: 10.21954/ou.rd.24749373
title: DEPA - Ethiopia Interview and Focus Group Discussion Transcripts

description: The 18 files in this item are interviews and focus group discussions conducted at the preliminary stage of the DEPA project. The are exploring understandings and experiences of gender-based violence and its impacts on the women and communities in Harar with teachers, health workers and affected women.The associated README file contains the metadata for each of the 18 individual data files. The information is organised sequentially by file number and provides the: file name, data type, a title and a description. The file names can be used to cross reference to get more detail on a particular file.The Ethiopia Project is a commissioned project with DEPA (Decolonising Education for Peace in Africa). DEPA was a 4 year project funded by the Arts and Humanities Council (AHRC) addressing the question: What are the different knowledges and values underpinning peace and how can these practices be connected and compared across countries to create curriculum content and mode of delivery in informal and formal settings, Secondary and Higher Education (HE), in order to decolonise peace education?
DOI: 10.21954/ou.rd.24749373.v2
title: DEPA - Ethiopia Interview and Focus Group Discussion Transcripts

description: The 18 files in this item are interviews and focus group discussions conducted at the preliminary stage of the DEPA project. The are exploring understandings and experiences of gender-based violence and its impacts on the women and communities in Harar with teachers, health workers and affected women.The associated README file contains the metadata for each of the 18 individual data files. The information is organised sequentially by file number and provides the: file name, data type, a title and a description. The file names can be used to cross reference to get more detail on a particular file.The Ethiopia Project is a commissioned project with DEPA (Decolonising Education for Peace in Africa). DEPA was a 4 year project funded by the Arts and Humanities Council (AHRC) addressing the question: What are the different knowledges and values underpinning peace and how can these practices be connected and compared across countries to create curriculum content and mode of delivery in informal and formal settings, Secondary and Higher Education (HE), in order to decolonise peace education?
DOI: 10.21954/ou.rd.24749373.v1
title: DEPA - Ethiopia Interview and Focus Group Discussion Transcripts

description: The 18 files in this item are interviews and focus group discussions conducted at the preliminary stage of the project. The are exploring understandings and experiences of gender-based violence and its impacts on the women and communities in Harar with teachers, health workers and affected women.
DOI: 10.6084/m9.figshare.10001759
title: MOESM5 of Genome-wide identification and characterization of TALE superfamily genes in cotton reveals their functions in regulating secondary cell wall biosynthesis

description: Additional file 5: Table S2. The detailed information of Ka/Ks for TALE family homologs in different Gossypium species.
DOI: 10.34740/kaggle/dsv/7572006
title: 🔥 Playing with Fire: Blackpink’s YT Stats 🔥
DOI: 10.6084/m9.figshare.10001609.v1
title: MOESM6 of Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression

description: Additional file 6. Proteins are identified by LC-MS that specifically associated with circFOXP1.
DOI: 10.6084/m9.figshare.12096888.v1
title: Additional file 2 of The preceding root system drives the composition and function of the rhizosphere microbiome

description: Additional file 2: Table S8 and Table S9. The relative abundance of microbial gene groups and taxonomic genus between different niches. This file includes the mean values and standard error for the heatmap in Fig. 4a and Fig. 4b.
DOI: 10.6084/m9.figshare.12623172
title: Additional file 1 of The polyphenol-rich extract from chokeberry (Aronia melanocarpa L.) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats

description: Additional file 1 Table S1. Chromatography condition. Table S2. Primer sequences. Figure S1. The weight (g) of heart, kidney, spleen, lung, pancreas and testicle in the Control, HF, AM and SV group rat. Values are means ± SEMs. Figure S2. Gut microbiota compositions at the genus level in HF, AM and SV group at day 10, day 20, day 30, day 40 after diet intervention. Values are presented as mean ± SEM. *P &lt; 0.05; **P &lt; 0.01; ***P &lt; 0.001; ns P &gt; 0.05. Figure S3. The relative contents of bile acids in HF, AM and SV group rat at day 10, day 20, day 30, day 40 after diet intervention. Values are presented as mean ± SEM. *P&lt;0.05; **P&lt;0.01; ***P&lt;0.001; ns P&gt;0.05. Figure S4. Microbiota compositions at the genus level in HF, AM and SV group at day 40 after diet intervention. Values are presented as mean ± SEM. *P&lt;0.05; **P&lt;0.01; ***P&lt;0.001; ns P&gt;0.05. Figure S5. The weight (g) of liver, kidney, spleen, iWAT, eWAT, pWAT and iBAT in FMT-HF and FMT-AM group rat. Values are means ± SEMs. Figure S6. Microbiota compositions at the genus level in FMT-HF and FMT-AM group at day 10, day 20, day 30 after microbiota transplantation from CBPs treatment rat. Values are presented as mean ± SEM. *P &lt; 0.05; **P &lt; 0.01; ***P &lt; 0.001; ns P &gt; 0.05.
DOI: 10.6084/m9.figshare.7380710.v1
title: Additional file 1: of Proteome modifications on tomato under extreme high light induced-stress

description: Spreadsheet (excel file) containing the abundance (ratios) of all proteins identified in all samples. Please refer to Methods for details on the data acquisition, sample preparation and database match. The “Raw Data” tab is a list of all proteins matched to the Solanum lycopersicum database under 1% FDR. The “Filtered” tab contains the proteins presenting more than 2 unique peptides. The “DiffExp_Burned”, “DiffExp_Limit” and “DiffExp_Regular” tabs contain a list of proteins found differentially expressed in each of the treatments. Proteins in green font color are upregulated, and the ones in blue color are downregulated. (XLSX 2799 kb)
DOI: 10.6084/m9.figshare.10002101
title: Data from The interdependence of corporate reputation and ownership: a network approach to quantify reputation.

description: data.csv contains the id, integrated control value and operating value of firms.
DOI: 10.6084/m9.figshare.10002101.v2
title: Data from The interdependence of corporate reputation and ownership: a network approach to quantify reputation.

description: data.csv contains the id, integrated control value and operating value of firms.
DOI: 10.6084/m9.figshare.10002107
title: Network from The interdependence of corporate reputation and ownership: a network approach to quantify reputation.

description: network.txt contains a list of weighted edges. Each line i,j,w describes ownership between firm i and firm j.
DOI: 10.6084/m9.figshare.10002110.v1
title: ownership network.txt from The interdependence of corporate reputation and ownership: a network approach to quantify reputation

description: This file describes the ownership network used in the paper. Each line i,j,w denotes the ownership between firm i and firm j with weight w.
DOI: 10.6084/m9.figshare.12623150
title: Additional file 4 of Preference of individuals in the treatment strategies of acute myocardial infarction in China: a discrete choice experiment

description: Additional file 4.
DOI: 10.6084/m9.figshare.12623150.v1
title: Additional file 4 of Preference of individuals in the treatment strategies of acute myocardial infarction in China: a discrete choice experiment

description: Additional file 4.
DOI: 10.6084/m9.figshare.10002113.v1
title: Eigen from The interdependence of corporate reputation and ownership: a network approach to quantify reputation

description: eigen.txt contains the eigen values of the ownership network.
DOI: 10.23641/asha.16821352
title: Effects of capsaicin on sputum removal (Wu et al., 2021)

description: <b>Background: </b>Timely and effective removal of respiratory secretions is of great significance for tracheotomized patients. The purpose of this study is to investigate the effectiveness of capsaicin nebulization to stimulate cough to promote early clearance of respiratory secretions in tracheotomized patients after hemorrhagic stroke.<b>Method: </b>This study implemented a randomized controlled design. Sixty-three patients who were tracheotomized following a hemorrhagic stroke completed this randomized controlled trial. In the control group, 33 cases were given a routine care after tracheotomy. In the intervention group, 30 cases were given a capsaicin solution nebulization in addition to the routine care. The daily sputum output and the number of sputum suctioning were observed. The differences in sputum viscosity, cough function, and Clinical Pulmonary Infection Score (CPIS) were compared between the two groups before and after the intervention. Vital sign changes during capsaicin nebulization and suctioning were compared between the two groups in a pilot study.<b>Results: </b>The daily sputum output of the capsaicin intervention group was significantly higher than that of the control group (<i>p</i> &lt; .05). The number of sputum suctioning of capsaicin group was less than that of the control group after intervention (<i>p</i> &lt; .05). The CPIS score of the capsaicin group was lower than that of the control group (<i>p</i> &lt; .05) after a 1-week intervention. Patients’ heart rate, respiratory rate, and oxygen saturation during capsaicin nebulization were not statistically different from those during routine sputum suctioning (<i>p</i> &gt; .05).<b>Conclusions: </b>Capsaicin atomization–induced cough can effectively promote sputum excretion of hemorrhagic stroke patients undergoing tracheotomy and has a good safety profile. The Clinical Trial registration number of this study is ChiCTR2000037772 (http://www.chictr.org.cns).<br><b>Supplemental Material S1.</b> Vital signs of patients [ M (QL, QU) ]. <br>Wu, C., Zhang, Y., Yang, L., Shen, F., Ma, C., & Shen, M. (2021). Effect of capsaicin atomization–induced cough on sputum excretion in tracheotomized patients after hemorrhagic stroke: A randomized controlled trial. <i>Journal of Speech, Language, and Hearing Research</i>. Advance online publication. https://doi.org/10.1044/2021_JSLHR-21-00151
DOI: 10.6084/m9.figshare.13671755.v1
title: An epithelial-mesenchymal transition-Related Long Non-Coding RNA signature to predict overall survival and immune microenvironment in Kidney Renal Clear Cell Carcinoma

description: Kidney renal clear cell carcinoma (ccRCC) is a malignant tumor originating from renal tubular epithelium, lncRNAs can regulate the occurrence and development of EMT by targeting EMT transcription factors. We constructed a new survival signature based on EMT-related differentially expressed lncRNAs obtained from The Cancer Genome Atlas (TCGA-KIRC). We first determined 1377 EMT-related lncRNAs, lncRNA AL035661.1 with the largest correlation coefficient and the target gene was <i>PFN2</i> (cor=0.843; <i>P</i>=1.37E-146). Meanwhile, we found an AUC of 0.758 in our signature and we predicted the AUC values of the patients’ 1, 2, 3-year survival rate as 0.768, 0.749, and 0.762 in TCGA cohort, respectively. Multivariate COX analysis was performed to determine if risk score was an independent prognostic predictor of OS. The results indicated that our risk score can be an independent predictor for OS (Univariate: HR=1.350, 95% CI=1.276-1.428, <i>P</i>&lt;0.001; Multivariate: HR=1.295, 95% CI=1.201-1.396, <i>P</i>&lt;0.001). We identified novel EMT-related lncRNAs markers for ccRCC prognosis. The underlying mechanism between EMT-related lncRNAs in ccRCC and tumor immunity is still unclear and requires further study.