cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17615/fj6j-he60
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 1)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.17615/zwkh-pf66
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 2)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.17615/7rxb-ya74
title: Non-invasive 4D transcranial contrast-enhanced functional ultrasound imaging in mice with Alzheimer’s Disease during vibrotactile stimulation (Part 3)

description: Functional ultrasound (fUS) is an imaging technique that can measure changes in cerebral blood flow (CBF). However, transcranial ultrasound imaging is challenging due to the aberration and reverberation of sound due to the skull. Microbubble contrast-enhancement can overcome sensitivity limitations. Here, we propose a completely non-invasive 4D contrast-enhanced fUS approach to image brain hemodynamics at high spatial (200 um) and temporal resolutions (20 ms), providing a method to better study the localized changes in brain activity. The capabilities of this technique are demonstrated in Alzheimer's Disease (AD), a neurodegenerative disorder that is one of the leading causes of disability and death. Compared to conventional neuroimaging tools that are used for diagnosis and monitoring the proposed technique has higher spatial and temporal resolution. To demonstrate the capabilities of this contrast-enhanced fUS technique to transcranially image volumetric cerebral hemodynamics, it was applied to five wild-type (WT) mice and five mice with AD at rest (baseline) during vibrotactile stimulation of the front or hind paw. WT mice, on average, experienced 10.7-23.9 % higher mean CBF for each stimulation case but 17.0-20.3 % lower mean connectivity than mice with AD. Five specific regions were highlighted in this comparison that are known to be affected by AD. These were the entorhinal cortex, hippocampus, thalamus, parietal cortex, and frontal cortex. AD mice exhibited hyper-connectivity in the hippocampus, one of the first regions affected by AD in this mouse model, and lower CBF in all five regions. Both the CBF and connectivity results from this technique agree with published gold-standard fMRI AD findings that account for the age of the animals. In summary, it is demonstrated that 4D fUS can non-invasively detect and monitor changes in cerebral hemodynamics associated with AD with high temporal resolution, enabling longitudinal functional assessments of these effects in rodent AD models.
DOI: 10.5281/zenodo.12696266
title: Simulated exome-sequencing data for a family study of lymphoid cancer

description: This repository contains all the data files for a simulated exome-sequencing study of 150 families, ascertained to contain at least four members affected with lymphoid cancer.  Please note that previous versions of this repository omitted a key file linking the genotypes of individuals to their family and individual IDs; this file, geno_key.txt, is now included. All other files remain the same as in previous versions.

The simulated data can be found in the files section below. The files are:



SLiM_output.txt - contains the SLiM-simulated, exome-wide, SNV data generated under an American-admixture demographic model,  for the American-admixed sub-population only.

SLiM_output_chr8&9.txt - contains the SLiM-simulated data above for all source populations as well as the American-admixed sub-population, but only for chromosomes 8 and 9.

sample_info.txt - contains pedigree information of all the disease-affected individuals and individuals connecting them along a line of descent, for all 150 ascertained pedigrees.

Genotypes.zip -  a zipfile that contains 22 text files of genotypes for each chromosome. The genotypes are for simulated single-nucleotide variants on the exome and are in gene-dosage format. 

geno_key.txt – a plain-text file that links the genotyped individuals to their family and individual IDs.

SNVmaps.zip -  a zipfile that contains 22 text files giving the single-nucleotide variant information for each chromosome. 

familial_cRV.txt - contains the familial causal rare variants for all 150 ascertained pedigrees.

study_peds.txt - contains the 150 pedigrees ascertained to contain four or more relatives affected with lymphoid cancer.

PLINKfiles.zip -  a zipfile that contains PLINK .fam, .bim and .bed files for all 22 of the chromosomes.


All the scripts used to generate these data can be found in the GitHub repository archived at https://zenodo.org/records/12694914

We have also uploaded one intermediate .Rdata file, Chromwide.Rdata, to save the user substantial time when running the associated RMarkdown script for the simulation. We recommend loading Chromwide.Rdata into your R work-space rather than generating it from scratch.
DOI: 10.5281/zenodo.12696267
title: Simulated exome-sequencing data for a family study of lymphoid cancer

description: This repository contains all the data files for a simulated exome-sequencing study of 150 families, ascertained to contain at least four members affected with lymphoid cancer.  Please note that previous versions of this repository omitted a key file linking the genotypes of individuals to their family and individual IDs; this file, geno_key.txt, is now included. All other files remain the same as in previous versions.

The simulated data can be found in the files section below. The files are:



SLiM_output.txt - contains the SLiM-simulated, exome-wide, SNV data generated under an American-admixture demographic model,  for the American-admixed sub-population only.

SLiM_output_chr8&9.txt - contains the SLiM-simulated data above for all source populations as well as the American-admixed sub-population, but only for chromosomes 8 and 9.

sample_info.txt - contains pedigree information of all the disease-affected individuals and individuals connecting them along a line of descent, for all 150 ascertained pedigrees.

Genotypes.zip -  a zipfile that contains 22 text files of genotypes for each chromosome. The genotypes are for simulated single-nucleotide variants on the exome and are in gene-dosage format. 

geno_key.txt – a plain-text file that links the genotyped individuals to their family and individual IDs.

SNVmaps.zip -  a zipfile that contains 22 text files giving the single-nucleotide variant information for each chromosome. 

familial_cRV.txt - contains the familial causal rare variants for all 150 ascertained pedigrees.

study_peds.txt - contains the 150 pedigrees ascertained to contain four or more relatives affected with lymphoid cancer.

PLINKfiles.zip -  a zipfile that contains PLINK .fam, .bim and .bed files for all 22 of the chromosomes.


All the scripts used to generate these data can be found in the GitHub repository archived at https://zenodo.org/records/12694914

We have also uploaded one intermediate .Rdata file, Chromwide.Rdata, to save the user substantial time when running the associated RMarkdown script for the simulation. We recommend loading Chromwide.Rdata into your R work-space rather than generating it from scratch.
DOI: 10.5281/zenodo.6499208
title: Simulated exome-sequencing data for a family study of lymphoid cancer

description: This repository contains all the data files for a simulated exome-sequencing study of 150 families ascertained to contain at least four members affected with lymphoid cancer. The simulated data can be found in the files section below. The files are: SLiM_output.txt - contains the SLiM-simulated, exome-wide, SNV data generated under an American-admixture demographic model, for the American-admixed sub-population only. SLiM_output_chr8&9.txt - contains the SLiM-simulated data above for all source populations as well as the American-admixed sub-population, but only for chromosomes 8 and 9. sample_info.txt - contains pedigree information of all the disease-affected individuals and individuals connecting them along a line of descent, for all 150 ascertained pedigrees. Genotypes.zip - a zipfile that contains 22 text files of genotypes for each chromosome. The genotypes are for simulated single-nucleotide variants on the exome and are in gene-dosage format. SNVmaps.zip - a zipfile that contains 22 text files giving the single-nucleotide variant information for each chromosome. familial_cRV.txt - contains the familial causal rare variants for all 150 ascertained pedigrees. study_peds.txt - contains the 150 pedigrees ascertained to contain four or more relatives affected with lymphoid cancer. PLINKfiles.zip - a zipfile that contains PLINK .fam, .bim and .bed files for all 22 of the chromosomes. All the scripts used to generate these data can be found in the GitHub repository archived at https://zenodo.org/record/6505385 . We have also uploaded one intermediate .Rdata file, Chromwide.Rdata, to save the user substantial time when running the associated RMarkdown script for the simulation. We recommend loading Chromwide.Rdata into your R work-space rather than generating it from scratch.
description: funding acknowledgement- Natural Sciences and Engineering Research Council of Canada RGPIN-04296-2018
DOI: 10.15468/dl.gc6mne
title: Occurrence Download

description: A dataset containing 3582087 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Saudi Arabia, Oman, Yemen, Qatar, Bahrain, United Arab Emirates, Egypt, Jordan, Iraq, Iran (Islamic Republic of), Palestine, State of, Lebanon, Libya, Algeria, Tunisia, Morocco, Mauritania, Western Sahara, Sudan, Somalia, Djibouti, Eritrea, Kuwait, Syrian Arab Republic, Ethiopia, Türkiye)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Passeriformes",
 "Year 2010-2024"
 ]
}

 The dataset includes 3582087 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018770-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.21227/4pb4-9457
title: Composite fiber Bragg gratings fabricated by femtosecond lasers for high-power fiber lasers

description: Fiber Bragg grating (FBG) is a key component in high-power fiber lasers. Mirror FBGs can act as cavity mirrors for fiber oscillators, and chirped and tilted fiber Bragg gratings (CTFBGs) can be used as all-fiber spectral filters to suppress nonlinear effects such as stimulated Raman scattering (SRS). Here a pair of mirror FBGs at 1080 nm are inscribed in fibers with a core diameter of 30 μm by femtosecond (fs) -lasers, and a high-power all-fiber oscillator is constructed based on the fs-written mirror FBGs. Next, a CTFBG at 1135 nm is inscribed on one side of the low reflectivity mirror FBG using fs-lasers, and the two FBGs on the same fiber form a composite FBG. SRS is effectively suppressed by CTFBG with a Raman suppression depth and width of 16 dB and 86 nm, respectively. The output power is increased to 9 kW and the Raman light ratio in the output power decreases by an order of magnitude. This work proves that composite FBG can enhance the compactness and stability of fiber oscillators and achieve effective SRS suppression, which is of significance for the development of high-power FBGs and fiber oscillators.
DOI: 10.15468/dl.gtd5wh
title: Occurrence Download

description: A dataset containing 105881 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hippophae rhamnoides L."
 ]
}

 The dataset includes 105881 records from 648 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018771-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-47036
title: Redemption tidings, vol. 21, nos. 1-26, 5 Jan. - 21 Dec. 1945

description: [description english/roman)] Issued fortnightly (every two weeks). "A full gospel magazine for all believers" -- subtitle. Includes Tidings from our missionaries in each issue (5-19 Jan., 16 Feb. - 27 Apr., 25 May - 3 Aug., 31 Aug. - 21 Dec. 1945) except vol. 21, nos. 3, 10 & 17.
DOI: 10.15468/dl.aufu8f
title: Occurrence Download

description: A dataset containing 102 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ptychohyla salvadorensis (Mertens, 1952))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 102 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060660-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pp7jwa
title: Occurrence Download

description: A dataset containing 33492 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Euphrasia salisburgensis Funck, Fagopyrum esculentum Moench)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 33492 records from 197 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0158682-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4rdmp4
title: Occurrence Download

description: A dataset containing 328435 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Stellaria media (L.) Vill., Stellaria glochidosperma (Murb.) Freyn, Stellaria cuspidata Willd. ex D.F.K.Schltdl.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 328435 records from 758 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0254069-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-47142
title: Redemption tidings, vol. 21, nos. 1-26, 5 Jan. - 21 Dec. 1945

description: [description english/roman)] Issued fortnightly (every two weeks). "A full gospel magazine for all believers" -- subtitle. Includes Tidings from our missionaries in each issue (5-19 Jan., 16 Feb. - 27 Apr., 25 May - 3 Aug., 31 Aug. - 21 Dec. 1945) except vol. 21, nos. 3, 10 & 17.
DOI: 10.15468/dl.8fp6xd
title: Occurrence Download

description: A dataset containing 213 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Boana wavrini (Parker, 1936))",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 213 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060663-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s8kbz9
title: Occurrence Download

description: A dataset containing 4666 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Calopteryx xanthostoma (Charpentier, 1825))"
 ]
}

 The dataset includes 4666 records from 98 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0144483-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/pcra-c14-46978
title: Redemption tidings, vol. 21, nos. 1-26, 5 Jan. - 21 Dec. 1945

description: [description english/roman)] Issued fortnightly (every two weeks). "A full gospel magazine for all believers" -- subtitle. Includes Tidings from our missionaries in each issue (5-19 Jan., 16 Feb. - 27 Apr., 25 May - 3 Aug., 31 Aug. - 21 Dec. 1945) except vol. 21, nos. 3, 10 & 17.
DOI: 10.15468/dl.er4h2a
title: Occurrence Download

description: A dataset containing 24028 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Lactarius tabidus Fr., Lactarius torminosus, Lactarius trivialis (Fr.) Fr.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 24028 records from 136 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0320428-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.