cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/q0kimo
title: Senate Unpassed Legislation 1893, S 199 committee on public charitable institutions - leave to withdraw, SC1/series 231, Petition of D.J. O'Farrell

description: &lt;p&gt;Petition subject: Incorporation &lt;/p&gt; &lt;p&gt;Original: &lt;a href="http://nrs.harvard.edu/urn-3:FHCL:25763570"&gt;http://nrs.harvard.edu/urn-3:FHCL:25763570&lt;/a&gt; &lt;/p&gt; &lt;p&gt;Date of creation: (unknown) &lt;/p&gt; &lt;p&gt;Petition location: [Boston] &lt;/p&gt; &lt;p&gt;Legislator, committee, or address that the petition was sent to: Henry Parkman, Suffolk; committee on public charitable institutions &lt;/p&gt; &lt;p&gt;Selected signatures:&lt;ol&gt;&lt;li&gt;D.J. O'Farrell&lt;/li&gt;&lt;/ol&gt; &lt;/p&gt; &lt;p&gt;Actions taken on dates: 1893-03-07,1893-03-08 &lt;/p&gt; &lt;p&gt;Legislative action: Received in the Senate on March 7, 1893 and referred to the committee on public charitable institutions and sent for concurrence and received in the House on March 8, 1893 and concurred &lt;/p&gt; &lt;p&gt;Total signatures: 1 &lt;/p&gt; &lt;p&gt;Legislative action summary: Received, referred, sent, received, concurred &lt;/p&gt; &lt;p&gt;Legal voter signatures (males not identified as non-legal): 1 &lt;/p&gt; &lt;p&gt;Female only signatures: No &lt;/p&gt; &lt;p&gt;Identifications of signatories: citizens, president of the corporation of the Working Boys' Home &lt;/p&gt; &lt;p&gt;Prayer format was &lt;a href="http://en.wikipedia.org/wiki/Printing"&gt;printed&lt;/a&gt; vs. &lt;a href="http://en.wikipedia.org/wiki/Manuscript"&gt;manuscript&lt;/a&gt;: Manuscript &lt;/p&gt; &lt;p&gt;Additional non-petition or unrelated documents available at archive: additional documents available &lt;/p&gt; &lt;p&gt;Additional archivist notes: Working Boys Home, Boston, charitable, homeless and neglected boys, good influences, teaching moral and industrial characteristics and habits, education, irrespective of color creed or nationality, race, stern duties, useful members of society, industrial school on Winchester Street in Newton, six hundred boys, appropriation &lt;/p&gt; &lt;p&gt;Location of the petition at the Massachusetts Archives of the Commonwealth: Senate Unpassed 1893, S 199 committee on public charitable institutions - leave to withdraw &lt;/p&gt; &lt;p&gt;Acknowledgements: Supported by the National Endowment for the Humanities (PW-5105612), Massachusetts Archives of the Commonwealth, Radcliffe Institute for Advanced Study at Harvard University, Center for American Political Studies at Harvard University, Institutional Development Initiative at Harvard University, and Harvard University Library.&lt;/p&gt;
DOI: 10.7910/dvn/sj4zna
title: 2000 Population Census Data Assembly, GUIZHOU Province; 贵州省2000人口普查统计资料汇编

description: The data files in this study have been created by merging individual per-county census files available as Microsoft Excel spreadsheets. Thus the study contains 111 data files, 1 file per census category. Each of these files contains merged census data for the following counties: NANMING 南明区 (520102), YUNYAN 云岩区 (520103), HUAXI 花溪区 (520111), WUDANG 乌当区 (520112), BAIYUN 白云区 (520113), XIAOHE 小河区 (520114), KAIYANG 开阳县 (520121), XIFENG 息烽县 (520122), XIUWEN 修文县 (520123), QINGZHEN 清镇市 (520181), ZHONGSHAN 钟山区 (520201), LIUZHITE 六枝特区 (520203), SHUICHENG 水城县 (520221), PAN 盘县 (520222), HONGHUAGANG 红花岗区 (520302), ZUNYI 遵义县 (520321), TONGZI 桐梓县 (520322), SUIYANG 绥阳县 (520323), ZHENGAN 正安县 (520324), DAOZHENGELAOZUMIAOZUZHZHIXIAN 道真仡佬族苗族自治县 (520325), WUCHUANGELAOZUMIAOZUZHZHIXIAN 务川仡佬族苗族自治县 (520326), FENGGANG 凤冈县 (520327), MEITAN 湄潭县 (520328), YUQING 余庆县 (520329), XISHUI 习水县 (520330), CHISHUI 赤水市 (520381), RENHUAI 仁怀市 (520382), XIXIU 西秀区 (520402), PINGBA 平坝县 (520421), PUDING 普定县 (520422), ZHENNINGBUYIZUMIAOZUZHZHIXIAN 镇宁布依族苗族自治县 (520423), GUANLINGBUYIZUMIAOZUZHZHIXIAN 关岭布依族苗族自治县 (520424), ZIYUNMIAOZUBUYIZUZHZHIXIAN 紫云苗族布依族自治县 (520425), TONGREN 铜仁市 (522201), JIANGKOU 江口县 (522222), YUPINGDONGZUZHZHIXIAN 玉屏侗族自治县 (522223), SHIQIAN 石阡县 (522224), SINAN 思南县 (522225), YINJIANGTUJIAZUMIAOZUZHZHIXIAN 印江土家族苗族自治县 (522226), DEJIANG 德江县 (522227), YANHETUJIAZUZHZHIXIAN 沿河土家族自治县 (522228), SONGTAOMIAOZUZHZHIXIAN 松桃苗族自治县 (522229), WANSHANTE 万山特区 (522230), XINGYI 兴义市 (522301), XINGREN 兴仁县 (522322), PUAN 普安县 (522323), QINGLONG 晴隆县 (522324), ZHENFENG 贞丰县 (522325), WANGMO 望谟县 (522326), CEHENG 册亨县 (522327), ANLONG 安龙县 (522328), BIJIE 毕节市 (522401), DAFANG 大方县 (522422), QIANXI 黔西县 (522423), JINSHA 金沙县 (522424), ZHIJIN 织金县 (522425), NAYONG 纳雍县 (522426), WEININGYIZUHUIZUMIAOZUZHZHIXIAN 威宁彝族回族苗族自治县 (522427), HEZHANG 赫章县 (522428), KAILI 凯里市 (522601), HUANGPING 黄平县 (522622), SHIBING 施秉县 (522623), SANSUI 三穗县 (522624), ZHENYUAN 镇远县 (522625), CENGONG 岑巩县 (522626), TIANZHU 天柱县 (522627), JINPING 锦屏县 (522628), JIANHE 剑河县 (522629), TAIJIANG 台江县 (522630), LIPING 黎平县 (522631), RONGJIANG 榕江县 (522632), CONGJIANG 从江县 (522633), LEISHAN 雷山县 (522634), MAJIANG 麻江县 (522635), DANZHAI 丹寨县 (522636), DUYUN 都匀市 (522701), FUQUAN 福泉市 (522702), LIBO 荔波县 (522722), GUIDING 贵定县 (522723), WENGAN 瓮安县 (522725), DUSHAN 独山县 (522726), PINGTANG 平塘县 (522727), LUODIAN 罗甸县 (522728), CHANGSHUN 长顺县 (522729), LONGLI 龙里县 (522730), HUISHUI 惠水县 (522731), SANDUSHUIZUZHZHIXIAN 三都水族自治县 (522732).
DOI: 10.7910/dvn/uk1lzk
title: A12_21442.JPG

description: Link to OCHRE database: &lt;a href = ''http://pi.lib.uchicago.edu/1001/org/ochre/e73cfe92-20a0-4efb-af64-02d09ba1f399'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/e73cfe92-20a0-4efb-af64-02d09ba1f399
DOI: 10.7910/dvn/urgski
title: LacI-DNA ultrafast force-clamp spectroscopy

description: ultrafast force clamp data on LacI-DNA interaction
DOI: 10.7910/dvn/zsbz7k
title: CCES Common Content, 2018

description: This is the main release of the 2018 CCES Common Content Dataset. The data includes a nationally representative sample of 60,000 American adults. This release includes the data from the survey, vote validation for the respondents, and a full guide and codebook. See the guide for a more detailed explanation of the data.
DOI: 10.7910/dvn/hn7ncb
title: Replication Data for: Partisan Portfolio Allocation in African Democracies

description: What determines partisan portfolio allocation in African democracies? Despite the vast literature on govern-ment formation in Europe and Latin America, there have been no studies of partisan portfolio allocation inAfrica. Although coalition governments are increasingly common in Africa, most studies focus on nationalleaders, and, thus, we know little about how ministerial posts are divided among cabinet parties. Using anoriginal dataset of coalition governments in Africa from 1990 to 2014, we show that existing theories of par-tisan portfolio allocation can be successfully applied to African democracies. We find that African partiesreceive ministerial portfolios in rough proportion to their size, that formateur parties in Africa receive moreministerial portfolios than their European counterparts, and that the ‘formateur bonus’ is greater in Africa’spresidential democracies than in its parliamentary ones. Our analyses suggest that scholars can benefit frompaying more attention to both coalition governments and legislatures in their analyses of African politics.
DOI: 10.7910/dvn/nraaw1
title: PM speciation database

description: HEI Air Quality database. This database was funded by HEI and prepared and maintained by Atmospheric and Environmental Research (AER). It contained information on levels of PM2.5 components and gases from the EPA’s Chemical Speciation Network (CSN), as well as meteorological, population and other relevant data. It was made available in association with Request for Applications 05-1 and to other investigators interested in using the information for studies on air quality and health. See also the NPACT reports by Lippmann and Vedal. The database is no longer updated. The final version can be downloaded here.
DOI: 10.7910/dvn/v2ndpc
title: Get Out the Vote: How to Increase Voter Turnout (5th Edition)

description: Data and analysis program files used to produce meta-analysis estimates for a variety of studies on voter mobilization.
DOI: 10.17632/fg9hrnkvjk
title: NATURAL GAS SOFC WITH GEOTHERMAL AUXILIARY SOURCE COBEM 2025

description: File containing the thermodynamic data of streams, used along the simulation of the system.
DOI: 10.17632/fg9hrnkvjk.1
title: NATURAL GAS SOFC WITH GEOTHERMAL AUXILIARY SOURCE COBEM 2025

description: File containing the thermodynamic data of streams, used along the simulation of the system.
DOI: 10.7910/dvn/7uwpdi
title: Replication Data to ''Explaining varying lobbying styles across the Atlantic An empirical test of the cultural and institutional explanations''

description: Hanegraaff M., A. Poletti, and J. Beyers (2016). "Explaining varying lobbying styles across the Atlantic An empirical test of the cultural and institutional explanations." Journal of Public Policy forthcoming.
description: There is consensus in the literature that policymaking in the US and Europe generates different lobbying styles. Two explanations for these differences have been developed so far. The first posits that distinct lobbying styles reflect different political cultures. The second attributes distinct lobbying styles to variation in the institutional context in which lobbyists operate. Studies that analyzed lobbying within the US and Europe and assessed the relative importance of these arguments are problematic because both explanations are consistent with observed differences in lobbying style. In this article we circumvent problems of observational equivalence focusing on European and American lobbyists who are active in a similar institutional venue, i.e. international diplomatic conferences. Relying on evidence collected at WTO Ministerial Conferences and UN Climate Summits, we test the relevance of alternative explanations for the variation in lobbying styles between European and American lobbyists. Our results give robust support to the institutional argument.
DOI: 10.17611/dp/18025198
title: Global ShakeMovie synthetic for January 07, 2020 MW 6.0 NEW BRITAIN REGION, P.N.G.
DOI: 10.17611/dp/18025202
title: Global ShakeMovie synthetic for January 08, 2020 MW 5.5 PACIFIC-ANTARCTIC RIDGE
DOI: 10.17611/dp/18025206
title: Global ShakeMovie synthetic for January 09, 2020 MW 6.4 EASTERN SIBERIA, RUSSIA
DOI: 10.17611/dp/18025228
title: Global ShakeMovie synthetic for January 10, 2020 MW 5.5 OFF COAST OF JALISCO, MEXICO
DOI: 10.17611/dp/18025263
title: Global ShakeMovie synthetic for January 11, 2020 MW 5.9 PUERTO RICO REGION
DOI: 10.17611/dp/18025273
title: Global ShakeMovie synthetic for January 10, 2020 MW 5.5 VANUATU ISLANDS
DOI: 10.17611/dp/18025277
title: Global ShakeMovie synthetic for January 12, 2020 MW 5.7 BOUVET ISLAND REGION
DOI: 10.17611/dp/18025293
title: Global ShakeMovie synthetic for January 15, 2020 MW 5.6 TIMOR REGION
DOI: 10.17611/dp/18025297
title: Global ShakeMovie synthetic for January 15, 2020 MW 5.5 NEAR COAST OF PERU
DOI: 10.17611/dp/18026332
title: Global ShakeMovie synthetic for January 16, 2020 MW 5.7 NORTH OF ASCENSION ISLAND
DOI: 10.17611/dp/18026336
title: Global ShakeMovie synthetic for January 16, 2020 MW 5.5 OFF EAST COAST OF KAMCHATKA
DOI: 10.17611/dp/18026340
title: Global ShakeMovie synthetic for January 17, 2020 MW 5.9 ASCENSION ISLAND REGION
DOI: 10.17611/dp/18027058
title: Global ShakeMovie synthetic for January 19, 2020 MW 6.0 SOUTHERN XINJIANG, CHINA
DOI: 10.17611/dp/18027062
title: Global ShakeMovie synthetic for January 19, 2020 MW 6.2 MINAHASSA PENINSULA, SULAWESI
DOI: 10.17611/dp/18027066
title: Global ShakeMovie synthetic for January 20, 2020 MW 6.1 SOUTH SANDWICH ISLANDS REGION
DOI: 10.17611/dp/18027758
title: Global ShakeMovie synthetic for January 18, 2020 MW 6.1 NEAR NORTH COAST OF IRIAN JAYA
DOI: 10.17611/dp/18028078
title: Global ShakeMovie synthetic for January 22, 2020 MW 5.6 NEAR EAST COAST OF KAMCHATKA
DOI: 10.17611/dp/18028082
title: Global ShakeMovie synthetic for January 22, 2020 MW 5.4 SOUTHEAST OF EASTER ISLAND
DOI: 10.17611/dp/18028599
title: Global ShakeMovie synthetic for January 23, 2020 MW 5.5 SANTIAGO DEL ESTERO PROV., ARG.
DOI: 10.17611/dp/18028603
title: Global ShakeMovie synthetic for January 22, 2020 MW 5.4 FIJI ISLANDS
DOI: 10.17611/dp/18028607
title: Global ShakeMovie synthetic for January 22, 2020 MW 5.6 TURKEY
DOI: 10.17611/dp/18028611
title: Global ShakeMovie synthetic for January 23, 2020 MW 6.2 ANDREANOF ISLANDS, ALEUTIAN IS.
DOI: 10.17611/dp/18029263
title: Global ShakeMovie synthetic for January 24, 2020 MW 5.5 TAJIKISTAN
DOI: 10.17611/dp/18029267
title: Global ShakeMovie synthetic for January 24, 2020 MW 6.8 TURKEY
DOI: 10.17611/dp/18044930
title: Global ShakeMovie synthetic for January 24, 2020 MW 5.2 XIZANG
DOI: 10.17611/dp/18044934
title: Global ShakeMovie synthetic for January 26, 2020 MW 5.6 ANDREANOF ISLANDS, ALEUTIAN IS.
DOI: 10.17611/dp/18044938
title: Global ShakeMovie synthetic for January 26, 2020 MW 6.1 ANDREANOF ISLANDS, ALEUTIAN IS.
DOI: 10.15468/dl.htzmrr
title: Occurrence Download

description: A dataset containing 218 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((104.30787 23.31192,106.66794 22.70005,108.21947 24.66678,109.11542 25.56273,110.36101 27.07055,111.19141 28.70949,111.08214 30.41399,111.01659 31.48476,109.15912 31.63773,108.0665 31.26623,106.01236 30.58881,105.22567 30.06435,105.029 29.45248,105.70643 27.44205,104.9853 26.50239,104.1112 25.32235,104.00193 23.53045,104.30787 23.31192))",
 "OccurrenceStatus is Present",
 "TaxonKey is Eriobotrya japonica"
 ]
}

 The dataset includes 218 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027438-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17611/dp/18044942
title: Global ShakeMovie synthetic for January 26, 2020 MW 5.8 ANDREANOF ISLANDS, ALEUTIAN IS.
DOI: 10.17611/dp/18044946
title: Global ShakeMovie synthetic for January 26, 2020 MW 5.8 ANDREANOF ISLANDS, ALEUTIAN IS.
DOI: 10.17611/dp/18044950
title: Global ShakeMovie synthetic for January 27, 2020 MW 6.3 SOLOMON ISLANDS
DOI: 10.17611/dp/18044954
title: Global ShakeMovie synthetic for January 28, 2020 MW 5.4 HOKKAIDO, JAPAN REGION
DOI: 10.15468/dl.ns8pdn
title: Occurrence Download

description: A dataset containing 39 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Syngonium podophyllum",
 "Country is Cuba",
 "HasCoordinate is true"
 ]
}

 The dataset includes 39 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0027439-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17611/dp/18045238
title: Global ShakeMovie synthetic for January 28, 2020 MW 5.5 DODECANESE ISLANDS, GREECE
DOI: 10.17611/dp/18045242
title: Global ShakeMovie synthetic for January 29, 2020 MW 6.0 SOLOMON ISLANDS
DOI: 10.17611/dp/18045522
title: Global ShakeMovie synthetic for January 28, 2020 MW 5.4 OFF COAST OF CENTRAL CHILE
DOI: 10.17611/dp/18045526
title: Global ShakeMovie synthetic for January 29, 2020 MW 5.9 NORTHERN MOLUCCA SEA
DOI: 10.17611/dp/18045530
title: Global ShakeMovie synthetic for January 30, 2020 MW 5.8 DODECANESE ISLANDS, GREECE
DOI: 10.17611/dp/18045786
title: Global ShakeMovie synthetic for January 30, 2020 MW 5.5 DODECANESE ISLANDS, GREECE
DOI: 10.17611/dp/18046892
title: Global ShakeMovie synthetic for January 31, 2020 MW 5.4 SOLOMON ISLANDS
DOI: 10.17611/dp/18046896
title: Global ShakeMovie synthetic for February 02, 2020 MW 5.6 OFF COAST OF CHIAPAS, MEXICO
DOI: 10.17611/dp/18049439
title: Global ShakeMovie synthetic for February 05, 2020 MW 5.7 MACQUARIE ISLAND REGION
DOI: 10.17611/dp/18049443
title: Global ShakeMovie synthetic for February 05, 2020 MW 6.2 JAVA, INDONESIA
DOI: 10.6084/m9.figshare.31190218
title: Development and biomechanical validation of a whole spine–thorax finite element model for quantitative biomechanical analysis

description: Objective: To develop a high-fidelity three-dimensional finite element model of the whole spine–thorax complex based on high-resolution computed tomography (CT) images of a healthy adult male, and to perform initial validation under representative loading conditions for quantitative analysis of load transmission, coupled motion, and stress distribution. We hypothesized that the model would reproduce published quasi-static segmental moment–rotation behavior and cadaveric thoracic impact responses within acceptable error ranges. Methods: High-resolution CT data of one healthy adult Chinese male volunteer (25 years; 175 cm; 70 kg) were used to reconstruct detailed anatomical structures, including vertebrae, intervertebral discs, ribs, costal cartilage, sternum, ligaments, respiratory muscles, lungs, and heart. Material properties were assigned based on literature data, and nonlinear contacts were defined among articular and cartilaginous structures. Model validation was carried out using two scenarios: pure-moment loading of the T12–L1 functional spinal unit and a frontal chest impact simulation, with the numerical responses compared against available experimental and cadaveric data. Results: The T12–L1 moment–rotation curves agreed well with published biomechanical ranges, and the frontal impact simulation produced a peak force (3270 N) and chest compression (79 mm) closely matching experimental results (3453 N and 80 mm), with errors of 5.3% and 1.25%, respectively. Conclusions: The finite element model reproduced static and dynamic responses of the spine–thorax complex within available experimental ranges for the loading conditions examined, providing an initial, non-invasive platform for investigating load transmission, coupled motion, and stress distribution under physiological, pathological, and interventional conditions.
DOI: 10.6084/m9.figshare.31190218.v1
title: Development and biomechanical validation of a whole spine–thorax finite element model for quantitative biomechanical analysis

description: Objective: To develop a high-fidelity three-dimensional finite element model of the whole spine–thorax complex based on high-resolution computed tomography (CT) images of a healthy adult male, and to perform initial validation under representative loading conditions for quantitative analysis of load transmission, coupled motion, and stress distribution. We hypothesized that the model would reproduce published quasi-static segmental moment–rotation behavior and cadaveric thoracic impact responses within acceptable error ranges. Methods: High-resolution CT data of one healthy adult Chinese male volunteer (25 years; 175 cm; 70 kg) were used to reconstruct detailed anatomical structures, including vertebrae, intervertebral discs, ribs, costal cartilage, sternum, ligaments, respiratory muscles, lungs, and heart. Material properties were assigned based on literature data, and nonlinear contacts were defined among articular and cartilaginous structures. Model validation was carried out using two scenarios: pure-moment loading of the T12–L1 functional spinal unit and a frontal chest impact simulation, with the numerical responses compared against available experimental and cadaveric data. Results: The T12–L1 moment–rotation curves agreed well with published biomechanical ranges, and the frontal impact simulation produced a peak force (3270 N) and chest compression (79 mm) closely matching experimental results (3453 N and 80 mm), with errors of 5.3% and 1.25%, respectively. Conclusions: The finite element model reproduced static and dynamic responses of the spine–thorax complex within available experimental ranges for the loading conditions examined, providing an initial, non-invasive platform for investigating load transmission, coupled motion, and stress distribution under physiological, pathological, and interventional conditions.
DOI: 10.5281/zenodo.18427234
title: AYLANA VA ELLIPSNI YASASHGA DOIR NAMUNALAR

description: Ushbu maqolada ikkinchi tartibli egri chiziqlardan aylana hamda ellipsga doir misol va masalalar yoritilgan hamda o‘rganilgan
DOI: 10.5281/zenodo.18427235
title: AYLANA VA ELLIPSNI YASASHGA DOIR NAMUNALAR

description: Ushbu maqolada ikkinchi tartibli egri chiziqlardan aylana hamda ellipsga doir misol va masalalar yoritilgan hamda o‘rganilgan
DOI: 10.15468/dl.4yefee
title: Occurrence Download

description: A dataset containing 1142 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Dithyrea californica",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 1142 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001426-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30397396
title: Synergetic attenuated inflammatory response and increased apoptosis confer high pathogenicity of Acinetobacter baumannii

description: Acinetobacter baumannii (A. baumannii) has emerged as a major global healthcare threat, ranking among the leading causes of both hospital-acquired and community-acquired infections. Its extensive antibiotic resistance complicates treatment, underscoring the need for therapeutic targets that elicit robust immune responses. This study identified two multidrug-resistant clinical strains of A. baumannii A.ba-R (rough) and A.ba-S (smooth). A.ba-R has thick and dense capsule polysaccharide, and exhibits high pathogenicity by suppressing host inflammatory responses and inducing apoptosis to evade immune surveillance. Conversely, A.ba-S possesses a thin capsular polysaccharide and triggers pyroptosis via inflammasome activation, causing pronounced inflammation. RNA-sequencing revealed that capsule polysaccharide, transmembrane secretion systems, and nutrient acquisition systems of A.ba-R might contribute to the induction of apoptosis. Our study reveals different roles of apoptosis and pyroptosis in the pathogenicity of A. baumannii and provides potential therapeutic targets against A. baumannii infections.
DOI: 10.6084/m9.figshare.30397396.v4
title: Synergetic attenuated inflammatory response and increased apoptosis confer high pathogenicity of Acinetobacter baumannii

description: Acinetobacter baumannii (A. baumannii) has emerged as a major global healthcare threat, ranking among the leading causes of both hospital-acquired and community-acquired infections. Its extensive antibiotic resistance complicates treatment, underscoring the need for therapeutic targets that elicit robust immune responses. This study identified two multidrug-resistant clinical strains of A. baumannii A.ba-R (rough) and A.ba-S (smooth). A.ba-R has thick and dense capsule polysaccharide, and exhibits high pathogenicity by suppressing host inflammatory responses and inducing apoptosis to evade immune surveillance. Conversely, A.ba-S possesses a thin capsular polysaccharide and triggers pyroptosis via inflammasome activation, causing pronounced inflammation. RNA-sequencing revealed that capsule polysaccharide, transmembrane secretion systems, and nutrient acquisition systems of A.ba-R might contribute to the induction of apoptosis. Our study reveals different roles of apoptosis and pyroptosis in the pathogenicity of A. baumannii and provides potential therapeutic targets against A. baumannii infections.