cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4107030
title: The effect of pre-eclampsia-like syndrome induced by L-NAME on learning and memory and hippocampal glucocorticoid receptor expression: A rat model

description: <i>Objective</i>: We aimed to study the impacts of pre-eclampsia on the cognitive and learning capabilities of adolescent rat offspring and to explore the possible underlying mechanisms at the molecular level. <i>Methods</i>: Pregnant rats were subcutaneously injected with saline solution (control) (<i>n</i> = 16) or NG-nitro-L-arginine methyl ester (L-NAME) (<i>n</i> = 16) from the 13th day of gestation until parturition. The brain tissues from fetal rats delivered by cesarean section were examined in both groups with hematoxylin and eosin (H&E) staining. Rats born vaginally in both groups were subjected to the Morris water maze test when 8-week-old and their hippocampi were analyzed for glucocorticoid receptor (GR) expression. <i>Results</i>: A pre-eclampsia-like model was successfully built in pregnant rats by infusion of the NO synthase inhibitor L-NAME, including phenotypes as maternal hypertension and proteinuria, high stillbirth rate, and fetal growth retardation. Neuroepithelial cell proliferation was found in the hippocampus of fetal rats in the L-NAME group. Grown to 8-week-old, the L-NAME group showed significantly longer escape latency than the control group in the beginning as well as in the end of navigation trials. At the same time, the swimming distance achieved by the L-NAME group was significantly longer than that of the control group. Such differences in cognitive and learning capabilities between the two groups were not gender dependent. Besides, the 8-week-old rats in the L-NAME group had increased GR expression in the hippocampus than the control group. <i>Conclusion</i>: Pre-eclampsia would impair cognitive and learning capabilities in adolescent offspring, and the upregulated expression of hippocampal GR may be involved in the underlying mechanisms.
DOI: 10.7910/dvn/v1rjpf/ihndcz
title: cbb20170308_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4107030.v1
title: The effect of pre-eclampsia-like syndrome induced by L-NAME on learning and memory and hippocampal glucocorticoid receptor expression: A rat model

description: <i>Objective</i>: We aimed to study the impacts of pre-eclampsia on the cognitive and learning capabilities of adolescent rat offspring and to explore the possible underlying mechanisms at the molecular level. <i>Methods</i>: Pregnant rats were subcutaneously injected with saline solution (control) (<i>n</i> = 16) or NG-nitro-L-arginine methyl ester (L-NAME) (<i>n</i> = 16) from the 13th day of gestation until parturition. The brain tissues from fetal rats delivered by cesarean section were examined in both groups with hematoxylin and eosin (H&E) staining. Rats born vaginally in both groups were subjected to the Morris water maze test when 8-week-old and their hippocampi were analyzed for glucocorticoid receptor (GR) expression. <i>Results</i>: A pre-eclampsia-like model was successfully built in pregnant rats by infusion of the NO synthase inhibitor L-NAME, including phenotypes as maternal hypertension and proteinuria, high stillbirth rate, and fetal growth retardation. Neuroepithelial cell proliferation was found in the hippocampus of fetal rats in the L-NAME group. Grown to 8-week-old, the L-NAME group showed significantly longer escape latency than the control group in the beginning as well as in the end of navigation trials. At the same time, the swimming distance achieved by the L-NAME group was significantly longer than that of the control group. Such differences in cognitive and learning capabilities between the two groups were not gender dependent. Besides, the 8-week-old rats in the L-NAME group had increased GR expression in the hippocampus than the control group. <i>Conclusion</i>: Pre-eclampsia would impair cognitive and learning capabilities in adolescent offspring, and the upregulated expression of hippocampal GR may be involved in the underlying mechanisms.
DOI: 10.7910/dvn/v1rjpf/o2fia6
title: cbb20170116_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4107000.v1
title: <i>De novo</i> methylation in male germ cells of the common marmoset monkey occurs during postnatal development and is maintained <i>in vitro</i>

description: The timing of <i>de novo</i> DNA methylation in male germ cells during human testicular development is yet unsolved. Apart from that, the stability of established imprinting patterns <i>in vitro</i> is controversially discussed. This study aimed at determining the timing of DNA <i>de novo</i> methylation and at assessing the stability of the methylation status <i>in vitro</i>. We employed the marmoset monkey (<i>Callithrix jacchus</i>) as it is considered the best non-human primate model for human testicular development. We selected neonatal, pre-pubertal, pubertal, and adult animals (n = 3, each) and assessed germ cell global DNA methylation levels by 5-methyl cytosine staining, and <i>Alu</i> elements and gene-specific methylation (<i>H19, LIT1, SNRPN, MEST, OCT4, MAGE-A4</i>, and <i>DDX-4)</i> by pyrosequencing. <i>De novo</i> methylation is progressively established during postnatal primate development and continues until adulthood, a process that is different in most other species. Importantly, once established, methylation patterns remained stable, as demonstrated using <i>in vitro</i> cultures. Thus, the marmoset monkey is a unique model for the study of postnatal DNA methylation mechanisms in germ cells and for the identification of epimutations and their causes.
DOI: 10.7910/dvn/v1rjpf/ranhbw
title: cbb20170422_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4106979
title: Using Conceptual Models and Qualitative Network Models to Advance Integrative Assessments of Marine Ecosystems

description: The complexity of ecosystem-based management (EBM) of natural resources has given rise to research frameworks such as integrated ecosystem assessments (IEA) that pull together large amounts of diverse information from physical, ecological, and social domains. Conceptual models are valuable tools for assimilating and simplifying this information to convey our understanding of ecosystem structure and functioning. Qualitative network models (QNMs) may allow us to conduct dynamic simulations of conceptual models to explore natural–social relationships, compare management strategies, and identify tradeoffs. We used previously developed QNM methods to perform simulations based on conceptual models of the California Current ecosystem's pelagic communities and related human activities and values. Assumptions about community structure and trophic interactions influenced the outcomes of the QNMs. In simulations where we applied unfavorable environmental conditions for production of salmon (<i>Oncorhynchus</i> spp.), intensive management actions only modestly mitigated declines experienced by salmon, but strongly constrained human activities. Moreover, the management actions had little effect on a human wellbeing attribute, sense of place. Sense of place was most strongly affected by a relatively small subset of all possible pair-wise interactions, although the relative influence of individual pair-wise interactions on sense of place grew more uniform as management actions were added, making it more difficult to trace effective management actions via specific mechanistic pathways. Future work will explore the importance of changing conceptual models and QNMs to represent management questions at finer spatial and temporal scales, and also examine finer representation of key ecological and social components.
DOI: 10.7910/dvn/v1rjpf/58297d
title: cbb20170612_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4106979.v1
title: Using Conceptual Models and Qualitative Network Models to Advance Integrative Assessments of Marine Ecosystems

description: The complexity of ecosystem-based management (EBM) of natural resources has given rise to research frameworks such as integrated ecosystem assessments (IEA) that pull together large amounts of diverse information from physical, ecological, and social domains. Conceptual models are valuable tools for assimilating and simplifying this information to convey our understanding of ecosystem structure and functioning. Qualitative network models (QNMs) may allow us to conduct dynamic simulations of conceptual models to explore natural–social relationships, compare management strategies, and identify tradeoffs. We used previously developed QNM methods to perform simulations based on conceptual models of the California Current ecosystem's pelagic communities and related human activities and values. Assumptions about community structure and trophic interactions influenced the outcomes of the QNMs. In simulations where we applied unfavorable environmental conditions for production of salmon (<i>Oncorhynchus</i> spp.), intensive management actions only modestly mitigated declines experienced by salmon, but strongly constrained human activities. Moreover, the management actions had little effect on a human wellbeing attribute, sense of place. Sense of place was most strongly affected by a relatively small subset of all possible pair-wise interactions, although the relative influence of individual pair-wise interactions on sense of place grew more uniform as management actions were added, making it more difficult to trace effective management actions via specific mechanistic pathways. Future work will explore the importance of changing conceptual models and QNMs to represent management questions at finer spatial and temporal scales, and also examine finer representation of key ecological and social components.
DOI: 10.7910/dvn/v1rjpf/wmpcri
title: cbb20170528_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/uufjvz
title: cbb20170616_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/dvtjgp
title: cbb20170912_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4106892
title: Grand Mean Images Generated in Study 1 and 2

description: Grand Mean Images Generated in Study 1 and 2
DOI: 10.6084/m9.figshare.4106892.v1
title: Grand Mean Images Generated in Study 1 and 2

description: Grand Mean Images Generated in Study 1 and 2
DOI: 10.7910/dvn/v1rjpf/xe89sf
title: cbb20170210_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/oj9obg
title: cbb20171218_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/hcbr8b
title: cbb20171224_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/esbbzv
title: cbb20170511_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/w0kjom
title: cbb20170120_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/zxjtxy
title: cbb20170812_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/snrqml
title: cbb20171229_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/1mlwob
title: cbb20171207_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3ttcu8
title: cbb20170815_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/f30uvz
title: cbb20170313_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/yq9zdt
title: cbb20170104_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vezepa
title: cbb20171214_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/foqeey
title: cbb20170118_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/tkgcqo
title: cbb20170820_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/otnhi9
title: cbb20170514_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/cnust6
title: cbb20170827_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/jgmwce
title: cbb20170212_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4106805
title: PowerPoint Slides for: Efficacy of Prophylactic Antibiotics at Peritoneal Catheter Insertion on Early Peritonitis: Data from the Catheter Section of the French Language Peritoneal Dialysis Registry

description: <b><i>Background:</i></b> International guidelines recommend the use of a prophylactic antibiotic before the peritoneal dialysis (PD) catheter can be inserted. The main objective of this study was to assess whether this practice is associated with a lower risk of early peritonitis and to estimate the magnitude of the centre effect. <b><i>Methods:</i></b> A retrospective, multi-centric study was conducted, in which data from the French Language Peritoneal Dialysis Registry was analysed. Patients were separated into 2 groups based on whether or not prophylactic antibiotics were used prior to catheter placement. <b><i>Results:</i></b> Out of the 2,014 patients who had a PD catheter placed between February 1, 2012 and December 31, 2014, 1,105 were given a prophylactic antibiotic. In a classical logit model, the use of prophylactic antibiotics was found to protect the individual against the risk of early peritonitis (OR 0.67, 95% CI 0.49-0.92). However, this association lost significance in a mixed logistic regression model with centre as a random effect: OR 0.73 (95% CI 0.48-1.09). Covariates associated with the risk of developing early peritonitis were age over 65: OR 0.73 (95% CI 0.39-0.85), body mass index over 35 kg/m<sup>2</sup>: OR 1.99 (95% CI 1.13-3.47), transfer to PD due to graft failure: OR 2.24 (95% CI 1.22-4.11), assisted PD: OR 1.96 (95% CI 1.31-2.93), and the use of the Moncrief technique: OR 3.07 (95% CI 1.85-5.11). <b><i>Conclusion:</i></b> There is a beneficial effect of prophylactic antibiotic used prior to peritoneal catheter placement, on the occurence of early peritonitis. However, the beneficial effect could be masked by a centre effect.<br>
DOI: 10.7910/dvn/v1rjpf/blgkfc
title: cbb20171118_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/0a5aev
title: cbb20170226_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4106286
title: Ulipristal acetate for pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands: cost minimization analysis and budget impact analysis

description: <b>Objective:</b> Ulipristal acetate has been found to be non-inferior to other pre-operative treatments of uterine fibroids, particularly leuprolide. The objective of this study was to assess the pharmacoeconomic profile of ulipristal acetate compared to leuprolide for the pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands. The analysis was performed and applied within the framework of the ulipristal acetate submission for reimbursement in 2012. <b>Methods:</b> A decision model was developed to compare the total costs of ulipristal acetate compared to leuprolide, the standard care in The Netherlands. The target population of this study corresponded to the type of patients included in the PEARL II clinical trial; i.e. women of reproductive age requiring pre-operative treatment for uterine fibroids. Sensitivity analysis was implemented to assess uncertainties. Data regarding costs, effects, and other input parameters were obtained from relevant published literatures, the Dutch Healthcare Insurance Board, and expert opinion obtained by means of a panel of experts from several medical centers in The Netherlands. <b>Results:</b> In The Netherlands, the total costs of ulipristal acetate and leuprolide were estimated at €4,216,027 and €4,218,095, respectively. The annual savings of ulipristal acetate were, therefore, estimated at €2,068. The major driver of this cost difference was the cost of administration for leuprolide. Sensitivity analyses showed that ulipristal acetate mostly remained cost-saving over a range of assumptions. The budget impact analysis indicated that the introduction of ulipristal acetate was estimated to result in cost savings in the first 3 years following the introduction. The results of this study were used in the decision on reimbursement of ulipristal acetate according to the Dutch Reference Pricing system in 2012. <b>Conclusion:</b> Ulipristal acetate was cost saving compared to leuprolide and has the potential to provide substantial savings on the healthcare budget in The Netherlands.
DOI: 10.7910/dvn/v1rjpf/ur58dd
title: cbb20170328_03.txt.gz

description: :unav
DOI: 10.17608/k6.auckland.4106283
title: RUS ICE data for Cryosphere paper

description: Raw data from our Resonant Ultrasound Experiments on man-man poly-crystalline ice.
DOI: 10.6084/m9.figshare.4106286.v2
title: Ulipristal acetate for pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands: cost minimization analysis and budget impact analysis

description: <b>Objective:</b> Ulipristal acetate has been found to be non-inferior to other pre-operative treatments of uterine fibroids, particularly leuprolide. The objective of this study was to assess the pharmacoeconomic profile of ulipristal acetate compared to leuprolide for the pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands. The analysis was performed and applied within the framework of the ulipristal acetate submission for reimbursement in 2012. <b>Methods:</b> A decision model was developed to compare the total costs of ulipristal acetate compared to leuprolide, the standard care in The Netherlands. The target population of this study corresponded to the type of patients included in the PEARL II clinical trial; i.e. women of reproductive age requiring pre-operative treatment for uterine fibroids. Sensitivity analysis was implemented to assess uncertainties. Data regarding costs, effects, and other input parameters were obtained from relevant published literatures, the Dutch Healthcare Insurance Board, and expert opinion obtained by means of a panel of experts from several medical centers in The Netherlands. <b>Results:</b> In The Netherlands, the total costs of ulipristal acetate and leuprolide were estimated at €4,216,027 and €4,218,095, respectively. The annual savings of ulipristal acetate were, therefore, estimated at €2,068. The major driver of this cost difference was the cost of administration for leuprolide. Sensitivity analyses showed that ulipristal acetate mostly remained cost-saving over a range of assumptions. The budget impact analysis indicated that the introduction of ulipristal acetate was estimated to result in cost savings in the first 3 years following the introduction. The results of this study were used in the decision on reimbursement of ulipristal acetate according to the Dutch Reference Pricing system in 2012. <b>Conclusion:</b> Ulipristal acetate was cost saving compared to leuprolide and has the potential to provide substantial savings on the healthcare budget in The Netherlands.
DOI: 10.7910/dvn/v1rjpf/ihvrf2
title: cbb20171203_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4106286.v1
title: Ulipristal acetate for pre-operative treatment of moderate to severe uterine fibroids in women of reproductive age in The Netherlands: cost minimization analysis and budget impact analysis

description: <b>Objective:</b> Ulipristal acetate has been found to be non-inferior to other pre-operative treatments of uterine fibroids, particularly leuprolide. The objective of this study was to assess the pharmacoeconomic profile of ulipristal acetate compared to leuprolide for the pre-operative treatment of moderate to severe uterine fibroids in women of reproductive age in The Netherlands. The analysis was performed and applied within the framework of the ulipristal acetate submission for reimbursement in 2012. <b>Methods</b>: A decision model was developed to compare the total costs of ulipristal acetate compared to leuprolide, the standard care in The Netherlands. The target population of this study corresponded to the type of patients included in the PEARL II clinical trial; i.e. women of reproductive age requiring pre-operative treatment for uterine fibroids. Sensitivity analysis was implemented, to assess uncertainties. Data regarding costs, effects, and other input parameters were obtained from relevant published literatures, the Dutch Healthcare Insurance Board and expert opinion obtained by means of a panel of experts from several medical centres in The Netherlands. <b>Results</b>: In The Netherlands, the total costs of ulipristal acetate and leuprolide were estimated at €4,216,027 and €4,218,095, respectively. The annual savings of ulipristal acetate were therefore estimated at €2,068. The major driver of this cost difference was the cost of administration for leuprolide. Sensitivity analyses showed that ulipristal acetate mostly remained cost-saving over a range of assumptions. The budget impact analysis indicated that the introduction of ulipristal acetate was estimated to result in cost savings in the first three years following the introduction. The results of this study were used in the decision on reimbursement of ulipristal acetate according to the Dutch Reference Pricing system in 2012. <b>Conclusion</b>: Ulipristal acetate was cost saving compared to leuprolide and has the potential to provide substantial savings on the healthcare budget in The Netherlands.
DOI: 10.7910/dvn/v1rjpf/u64xbm
title: cbb20170609_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/uhymbj
title: cbb20170117_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/fzmrvd
title: cbb20170218_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/v0w2ty
title: cbb20170720_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/bampr7
title: cbb20171109_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/td4lop
title: cbb20170717_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/2eqyq4
title: cbb20171011_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.4104651
title: False positives (non-redactions) extracted from ASIO surveillance records in National Archives of Australia Series A6119

description: This is a collection of false positives detected by a script to extract redactions (blacked out words and phrases) from surveillance files created by the Australian Security Intelligence Organisation (ASIO) and held in Series A6119 at the National Archives of Australia. <br>The digitised records were harvested from the NAA's online database as a collection of individual page images. These images were then processed to find and extract redactions. <br>After running the script, I manually removed non-redactions which are included in this fileset for comparison. There was about a 20% error rate. See the linked fileset for more information.<br>The filenames of the images provide important contextual information. For example:<br>1009279-p10-1-74-54.jpg -- has the following attributes <br>File barcode: 1009279 Page: 10 Redaction number: 1 Width: 74px Height: 54px <br>You can search the NAA database to find the original file using the barcode, or construct a link like: <br>https://owebrowse.herokuapp.com/items/1009279/pages/10/ <br>to view the page from which the redaction was extracted in my own experimental interface.
DOI: 10.6084/m9.figshare.4104651.v1
title: False positives (non-redactions) extracted from ASIO surveillance records in National Archives of Australia Series A6119

description: This is a collection of false positives detected by a script to extract redactions (blacked out words and phrases) from surveillance files created by the Australian Security Intelligence Organisation (ASIO) and held in Series A6119 at the National Archives of Australia. <br>The digitised records were harvested from the NAA's online database as a collection of individual page images. These images were then processed to find and extract redactions. <br>After running the script, I manually removed non-redactions which are included in this fileset for comparison. There was about a 20% error rate. See the linked fileset for more information.<br>The filenames of the images provide important contextual information. For example:<br>1009279-p10-1-74-54.jpg -- has the following attributes <br>File barcode: 1009279 Page: 10 Redaction number: 1 Width: 74px Height: 54px <br>You can search the NAA database to find the original file using the barcode, or construct a link like: <br>https://owebrowse.herokuapp.com/items/1009279/pages/10/ <br>to view the page from which the redaction was extracted in my own experimental interface.
DOI: 10.7910/dvn/v1rjpf/8oaixu
title: cbb20170710_03.txt.gz

description: :unav