cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7172402.v1
title: Activated kinase screening identifies the <i>IKBKE</i> oncogene as a positive regulator of autophagy

description: Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in adverse microenvironments and to oppose damages induced by anti-neoplastic therapies. Importantly, different human oncogenes are able to modulate this survival mechanism to support the transformation process, ultimately leading to ‘autophagy addiction’. Still, oncogenic signaling events, impinging on the control of autophagy, are poorly characterized, limiting our possibilities to take advantage of these mechanisms for therapeutic purposes. Here, we screened a library of activated kinases for their ability to stimulate autophagy. By this approach, we identified novel potential regulators of the autophagic process and, among them, the IKBKE oncogene. Specifically, we demonstrate that this oncoprotein is able to stimulate autophagy when overexpressed, an event frequently found in breast tumors, and that its activity is strictly required for breast cancer cells to support the autophagic process. Interestingly, different oncogenic pathways typically involved in breast cancer, namely ERBB2 and PI3K-AKT-MTOR, also rely on IKBKE to control this process. Ultimately, we show that IKBKE-dependent autophagy is necessary for breast cancer cell proliferation, suggesting an important supporting role for this oncogene and autophagy in these tumors. <b>Abbreviations:</b> AAK1: AP2 associated kinase 1; AMPK: 5ʹ-prime-AMP-activated protein kinase; AKT1: AKT serine/threonine kinase 1; BAF: bafilomycin A<sub>1</sub>; CA: constitutively activated; CDK17: cyclin dependent kinase 17; CDK18: cyclin dependent kinase 18; CHUK: conserved helix-loop-helix ubiquitous kinase; EGF: epidermal growth factor; ERBB2: erb-b2 receptor tyrosine kinase 2; FGF: fibroblast growth factor; FM: full medium; GALK2: galactokinase 2; IKBKB: inhibitor of nuclear factor kappa B kinase subunit beta; IKBKE: inhibitor of nuclear factor kappa B kinase subunit epsilon; IKK: IκB kinase complex; KD: kinase dead; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAPK1: mitogen-activated protein kinase 1; MAPK15: mitogen-activated protein kinase 15; MTORC1: mammalian target of rapamycin kinase complex 1; myr: myristoylation/myristoylated; NFKBIA: NFKB inhibitor alpha; PDGF: platelet derived growth factor; PFKL: phosphofructokinase, liver type; PRKAA1: protein kinase AMP-activated catalytic subunit alpha 1; PRKCD: protein kinase C delta; SQSTM1: sequestosome 1; TBK1: TANK binding kinase 1; TNBC: triple-negative breast cancer; TSC2: TSC complex subunit 2; WB: western blot; WT: wild-type.
DOI: 10.7284/106942
title: Winch data collected during research cruise W1105A using a Markey DUSH-5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172333
title: Surface et population des villes en système avec Noyon sur le temps long

description: Reconstitution des surfaces des villes en système avec Noyon sur le temps long et population de ces mêmes villes à partir du recensement de 1821<br>
DOI: 10.7284/106776
title: Multiplexed data collected during research cruise W1105B using a Hawaii UHDAS instrument system onboard the platform RV Wecoma
DOI: 10.6084/m9.figshare.7172333.v1
title: Surface et population des villes en système avec Noyon sur le temps long

description: Reconstitution des surfaces des villes en système avec Noyon sur le temps long et population de ces mêmes villes à partir du recensement de 1821<br>
DOI: 10.7284/105068
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1105B using a Ashtech ADU5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172282
title: Noyon : briques élémentaires par fonction et par pas de temps (100 ans & état de la structure intra-urbaine)

description: Jeu de données extrait de la base de données SHAUN, construite pour l'étude de l'évolution urbaine de la ville de Noyon (Oise, France). Il s'agit d'un tableau de contingence du nombre de briques élémentaires (ex : cimetière, église, atelier artisanal, etc.) qui existent par fonction urbaine sur le temps long de 2000 ans.<br>- lignes (dépendent des tableaux) : pas de temps chronologique arbitraire de 100 ans ([1;100], [101;200], [201;300]... jusqu'au début du 21e s.) ou état de la structure intra-urbaine identifié par une analyse experte,<br>- colonnes : fonctions urbaines définies selon l'adaptation du thésaurus du Centre National d'Archéologie Urbaine
DOI: 10.7284/106948
title: Winch data collected during research cruise W1105B using a Markey DUSH-5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172282.v1
title: Noyon : briques élémentaires par fonction et par pas de temps (100 ans & état de la structure intra-urbaine)

description: Jeu de données extrait de la base de données SHAUN, construite pour l'étude de l'évolution urbaine de la ville de Noyon (Oise, France). Il s'agit d'un tableau de contingence du nombre de briques élémentaires (ex : cimetière, église, atelier artisanal, etc.) qui existent par fonction urbaine sur le temps long de 2000 ans.<br>- lignes (dépendent des tableaux) : pas de temps chronologique arbitraire de 100 ans ([1;100], [101;200], [201;300]... jusqu'au début du 21e s.) ou état de la structure intra-urbaine identifié par une analyse experte,<br>- colonnes : fonctions urbaines définies selon l'adaptation du thésaurus du Centre National d'Archéologie Urbaine
DOI: 10.7284/106778
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise W1105C using a Hawaii UHDAS instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172231
title: Politics and the Popular in British Music Theatre of the Vietnam Era

description: British music-theatre works of the 1960s and early 1970s largely avoided direct engagement with contemporary political topics. Intriguing in this light is Michael Hall’s recent proposition that Brecht’s music theatre set the terms for younger British composers’ experiments with the genre. Brecht proved a complicated model, however, because of composers’ anxieties about music’s capability to convey sociopolitical messages, and their reluctance to accord popular music a progressive function. The entanglement of Vietnam War activism and rock music forms the backdrop for analyses of two works that do address Vietnam directly: Anthony Gilbert’s <i>The Scene-Machine</i> and George Newson’s <i>Arena</i> (both 1971) – both of which also pass pointed comment on different popular-music traditions. Both works highlight the difficulty in emulating Brecht’s model in an era when the concept of ‘the political’ was being significantly redefined, and the cultural gap between activist cadres and the wider population was unprecedentedly visible.
DOI: 10.6084/m9.figshare.7172228
title: suplementy.tar.gz

description: Suplementy do pracy magisterskiej Michał Karlicki
DOI: 10.6084/m9.figshare.7172231.v1
title: Politics and the Popular in British Music Theatre of the Vietnam Era

description: British music-theatre works of the 1960s and early 1970s largely avoided direct engagement with contemporary political topics. Intriguing in this light is Michael Hall’s recent proposition that Brecht’s music theatre set the terms for younger British composers’ experiments with the genre. Brecht proved a complicated model, however, because of composers’ anxieties about music’s capability to convey sociopolitical messages, and their reluctance to accord popular music a progressive function. The entanglement of Vietnam War activism and rock music forms the backdrop for analyses of two works that do address Vietnam directly: Anthony Gilbert’s <i>The Scene-Machine</i> and George Newson’s <i>Arena</i> (both 1971) – both of which also pass pointed comment on different popular-music traditions. Both works highlight the difficulty in emulating Brecht’s model in an era when the concept of ‘the political’ was being significantly redefined, and the cultural gap between activist cadres and the wider population was unprecedentedly visible.
DOI: 10.7284/106952
title: Anemometer data collected during research cruise W1105C using a RM Young 05103 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172225
title: 3D dataset of Meyer, Marty & Belvedere, Titanosaur trackways from the Late Cretaceous El Molino Formation of Bolivia (Cal Orck’o, Sucre)

description: Here we provide the 3D data, including the raw photos used to generate the photogrammetri models, and the mediotype (mean track) generated by DigTrace.<br><br>doi: https://doi.org/10.14241/asgp.2018.014<br>
DOI: 10.6084/m9.figshare.7172225.v1
title: 3D dataset of Meyer, Marty & Belvedere, Titanosaur trackways from the Late Cretaceous El Molino Formation of Bolivia (Cal Orck’o, Sucre)

description: Here we provide the 3D data, including the raw photos used to generate the photogrammetri models, and the mediotype (mean track) generated by DigTrace.<br><br>doi: https://doi.org/10.14241/asgp.2018.014<br>
DOI: 10.7284/106953
title: Anemometer data collected during research cruise W1105C using a RM Young 05103 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172228.v1
title: suplementy.tar.gz

description: Suplementy do pracy magisterskiej Michał Karlicki
DOI: 10.7284/106950
title: Fluorometer data collected during research cruise W1105C using a Turner 10-AU instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105069
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1105C using a Ashtech ADU5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107070
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1105C using a Garmin GPS-17HVS instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106951
title: Gyrocompass data collected during research cruise W1105C using a Sperry MK-37 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106949
title: Meteorological Station data collected during research cruise W1105C using a Vaisala PTU301 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107066
title: Radiometer data collected during research cruise W1105C using a Eppley RAD instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107067
title: Rain Gauge data collected during research cruise W1105C using a RM Young 50202 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106777
title: Singlebeam Echosounder data collected during research cruise W1105C using a Knudsen 3260 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107069
title: Singlebeam Echosounder data collected during research cruise W1105C using a Knudsen 3260 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107068
title: Water Temperature data collected during research cruise W1105C using a Sea-Bird SBE-38 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106954
title: Winch data collected during research cruise W1105C using a Markey DUSH-5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106780
title: Multiplexed data collected during research cruise W1106A using a Hawaii UHDAS instrument system onboard the platform RV Wecoma
DOI: 10.7284/106959
title: Anemometer data collected during research cruise W1106A using a RM Young 05103 instrument system onboard the platform RV Wecoma
DOI: 10.7284/111332
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise W1106A using a Sea-Bird SBE-911plus instrument system onboard the platform RV Wecoma
DOI: 10.7284/106956
title: Fluorometer data collected during research cruise W1106A using a Turner 10-AU instrument system onboard the platform RV Wecoma
DOI: 10.7284/105070
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1106A using a Ashtech ADU5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107076
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1106A using a Garmin GPS-17HVS instrument system onboard the platform RV Wecoma
DOI: 10.7284/106957
title: Gyrocompass data collected during research cruise W1106A using a Sperry MK-37 instrument system onboard the platform RV Wecoma
DOI: 10.7284/106955
title: Meteorological Station data collected during research cruise W1106A using a Vaisala PTU301 instrument system onboard the platform RV Wecoma
DOI: 10.7284/107071
title: Meteorological Station data collected during research cruise W1106A using a Vaisala HMT337 instrument system onboard the platform RV Wecoma
DOI: 10.7284/107072
title: Radiometer data collected during research cruise W1106A using a Eppley RAD instrument system onboard the platform RV Wecoma
DOI: 10.7284/107073
title: Rain Gauge data collected during research cruise W1106A using a RM Young 50202 instrument system onboard the platform RV Wecoma
DOI: 10.7284/106779
title: Singlebeam Echosounder data collected during research cruise W1106A using a Knudsen 3260 instrument system onboard the platform RV Wecoma
DOI: 10.7284/107075
title: Singlebeam Echosounder data collected during research cruise W1106A using a Knudsen 3260 instrument system onboard the platform RV Wecoma
DOI: 10.7284/107074
title: Thermometer data collected during research cruise W1106A using a Sea-Bird SBE-38 instrument system onboard the platform RV Wecoma
DOI: 10.7284/106960
title: Winch data collected during research cruise W1106A using a Markey DUSH-5 instrument system onboard the platform RV Wecoma
DOI: 10.7284/106782
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise W1106B using a Hawaii UHDAS instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106964
title: Anemometer data collected during research cruise W1106B using a RM Young 05103 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106965
title: Anemometer data collected during research cruise W1106B using a RM Young 05103 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/111334
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise W1106B using a Sea-Bird SBE-911+ instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106962
title: Fluorometer data collected during research cruise W1106B using a Turner 10-AU instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105071
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1106B using a Ashtech ADU5 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107082
title: GNSS (Global Navigation Satellite System) data collected during research cruise W1106B using a Garmin GPS-17HVS instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7172000
title: Supplementary Material for: Structure-Activity Relationship of the GPR55 Antagonist, CID16020046

description: <b><i>Background/Aims:</i></b> CID16020046 blocks the effect of the lipid lysophosphatidylinositol (LPI) at its receptor, GPR55. CID16020046 and another antagonist, ML193, have been used to investigate GPR55-mediated effects of LPI on cells, tissues, and in vivo. Here we describe the structure-activity relationship of CID16020046. <b><i>Methods:</i></b> Yeast or human cells were engineered to express GPR55 or control receptors. Cells were pretreated with a test agent before agonist challenge. Functional responses were quantified by yeast gene-reporter or calcium imaging. <b><i>Results:</i></b> Three substituents around the central pyrazololactam core of CID16020046 are each tolerant to substitution without abolishing GPR55 activity. Analogues of CID16020046 with potency at GPR55 ranging &gt;1,000-fold are described, including several lacking activity up to the top concentration tested. One analogue, compound <i>1</i> (GSK875734A), has approximately 50-fold greater potency than CID16020046 in an inverse agonist assay. CID16020046, ML193 and 2 further antagonists (ML191 and ML192) all block the effect of a surrogate agonist at human GPR55. ML193, CID16020046 and several other examples of the pyrazololactam chemotype were also shown to antagonise rat GPR55. <b><i>Conclusion:</i></b> These data confirm the utility of CID16020046 and ML193 as tools to investigate the physiological role of GPR55, and offer starting points for GPR55 antagonists with optimised pharmacokinetic or other properties.
DOI: 10.7284/106963
title: Gyrocompass data collected during research cruise W1106B using a Sperry MK-37 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.21954/ou.rd.7171997
title: Principal Möbius function values for permutations under classic pattern containment

description: These files have the value of the principal Möbius function \mu[1, \pi] for all canonical permutations with length 12 or less.<br>A permutation is canonical if, amongst the symmetries of the permutation, it has smallest lexicographic order.<br>Each line contains the permutation, the number of symmetries, and the value of the principal Möbius function, separated by semi-colons. For example,<br>{1,3,2} ; 4 ; -1<br>tells us that the permutation 132 has four symmetries, and that the value of the principal Möbius function is -1.<br><br><br><br>
DOI: 10.6084/m9.figshare.7172000.v1
title: Supplementary Material for: Structure-Activity Relationship of the GPR55 Antagonist, CID16020046

description: <b><i>Background/Aims:</i></b> CID16020046 blocks the effect of the lipid lysophosphatidylinositol (LPI) at its receptor, GPR55. CID16020046 and another antagonist, ML193, have been used to investigate GPR55-mediated effects of LPI on cells, tissues, and in vivo. Here we describe the structure-activity relationship of CID16020046. <b><i>Methods:</i></b> Yeast or human cells were engineered to express GPR55 or control receptors. Cells were pretreated with a test agent before agonist challenge. Functional responses were quantified by yeast gene-reporter or calcium imaging. <b><i>Results:</i></b> Three substituents around the central pyrazololactam core of CID16020046 are each tolerant to substitution without abolishing GPR55 activity. Analogues of CID16020046 with potency at GPR55 ranging &gt;1,000-fold are described, including several lacking activity up to the top concentration tested. One analogue, compound <i>1</i> (GSK875734A), has approximately 50-fold greater potency than CID16020046 in an inverse agonist assay. CID16020046, ML193 and 2 further antagonists (ML191 and ML192) all block the effect of a surrogate agonist at human GPR55. ML193, CID16020046 and several other examples of the pyrazololactam chemotype were also shown to antagonise rat GPR55. <b><i>Conclusion:</i></b> These data confirm the utility of CID16020046 and ML193 as tools to investigate the physiological role of GPR55, and offer starting points for GPR55 antagonists with optimised pharmacokinetic or other properties.
DOI: 10.7284/106961
title: Meteorological Station data collected during research cruise W1106B using a Vaisala PTU301 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.21954/ou.rd.7171997.v1
title: Principal Möbius function values for permutations under classic pattern containment

description: These files have the value of the principal Möbius function \mu[1, \pi] for all canonical permutations with length 11 or less.<br>A permutation is canonical if, amongst the symmetries of the permutation, it has smallest lexicographic order.<br>Each line contains the permutation, the number of symmetries, and the value of the principal Möbius function, separated by semi-colons. For example,<br>{1,3,2} ; 4 ; -1<br>tells us that the permutation 132 has four symmetries, and that the value of the principal Möbius function is -1.<br><br><br><br>
DOI: 10.21954/ou.rd.7171997.v2
title: Principal Möbius function values for permutations under classic pattern containment

description: These files have the value of the principal Möbius function \mu[1, \pi] for all canonical permutations with length 12 or less.<br>A permutation is canonical if, amongst the symmetries of the permutation, it has smallest lexicographic order.<br>Each line contains the permutation, the number of symmetries, and the value of the principal Möbius function, separated by semi-colons. For example,<br>{1,3,2} ; 4 ; -1<br>tells us that the permutation 132 has four symmetries, and that the value of the principal Möbius function is -1.<br><br><br><br>
DOI: 10.7284/107077
title: Meteorological Station data collected during research cruise W1106B using a Vaisala HMT337 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107078
title: Radiometer data collected during research cruise W1106B using a Eppley RAD instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/107079
title: Rain Gauge data collected during research cruise W1106B using a RM Young 50202 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/106781
title: Singlebeam Echosounder data collected during research cruise W1106B using a Knudsen 3260 instrument system onboard the platform RV Wecoma

description: Original (unprocessed) data collected during a Field_expedition