cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.13821564
title: Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

description: The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. However, the structural relationship between aggregation propensity and biological activity remains unclear. We employed a multi-disciplinary approach, including computational modeling, NMR, cross-linking mass spectrometry, and cell models to engineer tau sequences that modulate its structural ensemble. Our findings show that substitutions near the conserved 'PGGG' β-turn motif informed by tau isoform context reduce tau aggregation in vitro and cells and can even counteract aggregation from disease-associated proline-to-serine mutations. Engineered tau sequences maintain microtubule binding and explain why 3R isoforms exhibit reduced pathogenesis compared to 4R. We propose a simple mechanism to reduce the formation of pathogenic tau species while preserving biological function, thus offering insights for therapeutic strategies aimed at reducing tau protein misfolding in neurodegenerative diseases.

Description of Source Data and Supplementary Data: All MD, NMR (peptide and tauRD), ThT, XL-MS, MT stabilization, MT:tau modeling, and cell-based aggregation data are available in the Source_Data directory as Data S1, Data S2, Data S3, Data S4, Data S5, Data S6, Data S7, and Data S8, respectively. Supplementary Data for raw MD trajectory files, structure files for MSM modeling and validation file, and tau:MT modeling are available as "Supplementary_Data_MD_Trajectories_Structures", "Supplementary_Data_MSM_models_Structures" and "Supplementary_Data_MT-tau_complex_models", respectively."
DOI: 10.5281/zenodo.17081119
title: Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

description: The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. However, the structural relationship between aggregation propensity and biological activity remains unclear. We employed a multi-disciplinary approach, including computational modeling, NMR, cross-linking mass spectrometry, and cell models to engineer tau sequences that modulate its structural ensemble. Our findings show that substitutions near the conserved 'PGGG' β-turn motif informed by tau isoform context reduce tau aggregation in vitro and cells and can even counteract aggregation from disease-associated proline-to-serine mutations. Engineered tau sequences maintain microtubule binding and explain why 3R isoforms exhibit reduced pathogenesis compared to 4R. We propose a simple mechanism to reduce the formation of pathogenic tau species while preserving biological function, thus offering insights for therapeutic strategies aimed at reducing tau protein misfolding in neurodegenerative diseases.

Description of Source Data and Supplementary Data: All MD, NMR (peptide and tauRD), ThT, XL-MS, MT stabilization, MT:tau modeling, and cell-based aggregation data are available in the Source_Data directory as Data S1, Data S2, Data S3, Data S4, Data S5, Data S6, Data S7, and Data S8, respectively. Supplementary Data for raw MD trajectory files, structure files for MSM modeling and validation file, and tau:MT modeling are available as "Supplementary_Data_MD_Trajectories_Structures", "Supplementary_Data_MSM_models_Structures" and "Supplementary_Data_MT-tau_complex_models", respectively."
DOI: 10.15468/dl.t8yufe
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Artemisia biennis",
 "Country is Denmark",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009065-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bgbx54
title: Occurrence Download

description: A dataset containing 117 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Apodemus latronum"
 ]
}

 The dataset includes 117 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009066-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cp2kh3
title: Occurrence Download

description: A dataset containing 518 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Artemisia biennis",
 "Country is France",
 "HasCoordinate is true"
 ]
}

 The dataset includes 518 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009067-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wm2vwc
title: Occurrence Download

description: A dataset containing 162 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Artemisia biennis",
 "Country is Germany",
 "HasCoordinate is true"
 ]
}

 The dataset includes 162 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009068-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.58053/mapbiomas/ceslmp
title: Destaques do mapeamento anual de cobertura e uso da terra - Bioma Amazônia - MapBiomas Brasil Coleção 10 (1985-2024)

description: Documento com os principais destaques do mapeamento anual de cobertura e uso da terra sobre o bioma Amazônia para o período de 1985 a 2024
DOI: 10.15468/dl.6788xp
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Standella ovalina",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009070-250914085247600/datasets/export for details.
DOI: 10.15468/dl.82kh3v
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Nomorhamphus philippinus)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009071-250914085247600/datasets/export for details.
DOI: 10.15468/dl.cz4mew
title: Occurrence Download

description: A dataset containing 5389 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "Year is 1900"
 ]
}

 The dataset includes 5389 records from 109 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009072-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.duweje
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Artemisia biennis",
 "Country is Ireland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009076-250914085247600/datasets/export for details.
DOI: 10.15468/dl.smea7p
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Artemisia biennis",
 "Country is Iran (Islamic Republic of)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009074-250914085247600/datasets/export for details.
DOI: 10.26179/ctcy-f258
title: In situ observations of waves in sea ice and sea ice drift near Casey Station
DOI: 10.15468/dl.7zrvy7
title: Occurrence Download

description: A dataset containing 289 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Cordia alliodora"
 ]
}

 The dataset includes 289 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009075-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.urbqn5
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Artemisia biennis",
 "Country is Italy",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009077-250914085247600/datasets/export for details.
DOI: 10.15468/dl.x38uu2
title: Occurrence Download

description: A dataset containing 469 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tresus capax",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Occurrence evidence)",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is one of (Absent)"
 ]
 }
 }
 ]
}

 The dataset includes 469 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009078-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nd7mfc
title: Occurrence Download

description: A dataset containing 30033 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Colombia, Ecuador, Venezuela (Bolivarian Republic of), Peru, El Salvador, Guatemala, Honduras, Nicaragua, Costa Rica, Panama, Mexico)",
 "OccurrenceStatus is Present",
 "TaxonKey is Didelphis marsupialis"
 ]
}

 The dataset includes 30033 records from 502 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009079-250914085247600/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dpadly
title: Occurrence Download

description: A dataset containing 1094 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is United States of America",
 "Country is Canada"
 ]
 },
 "HasCoordinate is true",
 "TaxonKey is Hibiscus syriacus L.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1094 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0032889-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qtudrr
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Agrianthus campestris Mart. ex DC.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 5 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006365-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r7tlcv
title: Occurrence Download

description: A dataset containing 116 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Numérisation des données faune contenues dans les Bulletins de la Société Linnéenne de Bordeaux-Bulletin de la Société Linnéenne de Bordeaux, Tome 144 (N.S) n° 37 (4), 2009 - Données faune"
 ]
}

 The dataset includes 116 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022799-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xmz3uz
title: Occurrence Download

description: A dataset containing 1643261 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Specimen"
 ]
 },
 "Country is Costa Rica",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "or" : [
 "TaxonKey is Turdidae",
 "TaxonKey is Troglodytidae",
 "TaxonKey is Thraupidae"
 ]
 }
 ]
}

 The dataset includes 1643261 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053884-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fxlmj7
title: Occurrence Download

description: A dataset containing 52 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Fungi",
 "DecimalLatitude is greater than 41.3827414480281",
 "DecimalLatitude is less than 41.9241895224454",
 "DecimalLongitude is greater than -83.1759388059129",
 "DecimalLongitude is less than -82.4482405718397"
 ]
}

 The dataset includes 52 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006365-180824113759888/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n2ene7
title: Occurrence Download

description: A dataset containing 159 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Amorpha georgiana Wilbur"
 ]
}

 The dataset includes 159 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0333322-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uyhgb7
title: Occurrence Download

description: A dataset containing 234352 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Material sample"
 ]
 },
 "HasCoordinate is true",
 "TaxonKey is Phyllostomidae",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 234352 records from 254 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002610-200127171203522/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.iu43yj
title: Occurrence Download

description: A dataset containing 1545 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Tagetes filifolia Lag."
 ]
}

 The dataset includes 1545 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006365-181003121212138/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8b8hns
title: Occurrence Download

description: A dataset containing 1113 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Siphonaria pectinata (Linnaeus, 1758)"
 ]
}

 The dataset includes 1113 records from 45 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021906-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zyvinr
title: Occurrence Download

description: A dataset containing 59908 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Issue is Geodetic datum assumed WGS84",
 "HasCoordinate is true",
 "TaxonKey is Ulex europaeus L.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 59908 records from 263 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011208-200127171203522/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.we52gt
title: Occurrence Download

description: A dataset containing 15380 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "TaxonKey is Gallinula chloropus (Linnaeus, 1758)"
 ]
}

 The dataset includes 15380 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002626-200127171203522/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r22n29
title: Occurrence Download

description: A dataset containing 4256 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Petunia Juss.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 4256 records from 199 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012946-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ehrcnt
title: Occurrence Download

description: A dataset containing 2977 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Philadelphus coronarius L."
 ]
}

 The dataset includes 2977 records from 216 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006475-150922153815467/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eci6fk
title: Occurrence Download

description: A dataset containing 57 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Zimbabwe",
 "DatasetKey is Mosquito Occurrence Dataset",
 "HasCoordinate is true",
 "TaxonKey is Anopheles arabiensis Patton, 1905",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 57 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017319-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2ygs82
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Continent is South America",
 "TaxonKey is Amorphopus Serville, 1838"
 ]
}

 The dataset includes 10 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053897-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vsybr0
title: Occurrence Download

description: A dataset containing 287 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Camponotus senex (Smith, 1858)"
 ]
}

 The dataset includes 287 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006365-190320150433242/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.knq2ez
title: Occurrence Download

description: A dataset containing 3592 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Ireland, United Kingdom of Great Britain and Northern Ireland, Svalbard and Jan Mayen, Norway, Sweden, Finland, Estonia, Latvia, Lithuania, Portugal, Spain, France, Germany, Belgium, Netherlands, Switzerland, Austria, Italy, Greece, Cyprus, Türkiye, Russian Federation, Belarus, Ukraine, Poland, Czechia, Hungary, Slovakia, Romania, Bulgaria, North Macedonia, Albania, Montenegro, Serbia, Kosovo, Bosnia and Herzegovina, Slovenia, Croatia)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Phlomis fruticosa L."
 ]
}

 The dataset includes 3592 records from 93 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056898-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zy2lss
title: Occurrence Download

description: A dataset containing 38 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brazil",
 "Issue is Geodetic datum assumed WGS84",
 "HasCoordinate is true",
 "TaxonKey is Ulex europaeus L.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 38 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011211-200127171203522/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.o0p3xs
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Zamia ipetiensis D.W.Stev.",
 "DecimalLatitude is greater than or equal to -90",
 "DecimalLongitude is greater than or equal to -180"
 ]
}

 The dataset includes 6 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0029145-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sxandw
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lucania interioris Hubbs & Miller, 1965"
 ]
}

 The dataset includes 24 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011198-181003121212138/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pj9yio
title: Occurrence Download

description: A dataset containing 10534 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "HasCoordinate is true",
 "TaxonKey is Culicoides Latreille, 1809",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 10534 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015329-200127171203522/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.24414/rob-gnss-gbgn00bel
title: GNSS data of GBGN00BEL, Geraardsbergen, Belgium

description: Permanent GNSS station dataset as daily RINEX files
DOI: 10.15468/dl.g3ttnf
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Calcisuccinea Pilsbry, 1948"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017580-191105090559680/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.