cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1568779.v1
title: Spontaneous Dissociation of Fluocinolone Acetonide Sustained Release Implant (Retisert) with Dislocation into the Anterior Chamber

description: <i>Purpose</i>: To report two cases of spontaneous Retisert implant dissociation with dislocation of the medication reservoir into the anterior chamber.<i>Design and methods</i>: Case reports.<i>Results</i>: Two patients with chronic, noninfectious uveitis following Retisert implantation between 6 and 7 years prior presented with a complaint of a “white spot” in their right eyes. Both patients had previous pars plana vitrectomies. Anterior segment examination revealed a dislocated medication reservoir of the Retisert implant in the inferior portion of anterior chamber with associated reservoir-corneal endothelial touch and stromal edema. The reservoirs were subsequently retrieved via a pars plana approach and removed from the anterior chamber through a corneal incision.<i>Conclusions</i>: Spontaneous dissociation of the Retisert implant with dislocation of the medication reservoir into the anterior chamber can be a late complication of Retisert implantation. Eye care professionals and patients should be aware of this complication, particularly with long-term intraocular retention of this device.
DOI: 10.6084/m9.figshare.1568776
title: Molecular malaria diagnostics: A systematic review and meta-analysis

description: Accurate diagnosis of malaria is essential for identification and subsequent treatment of the disease. Currently, microscopy and rapid diagnostic tests are the most commonly used diagnostics, next to treatment based on clinical signs only. These tests are easy to deploy, but have a relatively high detection limit. With declining prevalence in many areas, there is an increasing need for more sensitive diagnostics. Molecular tools may be a suitable alternative, although costs and technical requirements currently hamper their implementation in resource limited settings. A range of (near) point-of-care diagnostics is therefore under development, including simplifications in sample preparation, amplification and/or read-out of the test. Accuracy data, in combination with technical characteristics, are essential in determining which molecular test, if any, would be the most promising to be deployed. This review presents a comprehensive overview of the currently available molecular malaria diagnostics, ranging from well-known tests to platforms in early stages of evaluation, and systematically evaluates their published accuracy. No important difference in accuracy was found between the most commonly used PCR-based assays (conventional, nested and real-time PCR), with most of them having high sensitivity and specificity, implying that there are no reasons other than practical ones to choose one technique over the other. Loop-mediated isothermal amplification and other (novel) diagnostics appear to be highly accurate as well, with some offering potential to be used in resource-limited settings.
DOI: 10.6084/m9.figshare.1568776.v1
title: Molecular malaria diagnostics: A systematic review and meta-analysis

description: Accurate diagnosis of malaria is essential for identification and subsequent treatment of the disease. Currently, microscopy and rapid diagnostic tests are the most commonly used diagnostics, next to treatment based on clinical signs only. These tests are easy to deploy, but have a relatively high detection limit. With declining prevalence in many areas, there is an increasing need for more sensitive diagnostics. Molecular tools may be a suitable alternative, although costs and technical requirements currently hamper their implementation in resource limited settings. A range of (near) point-of-care diagnostics is therefore under development, including simplifications in sample preparation, amplification and/or read-out of the test. Accuracy data, in combination with technical characteristics, are essential in determining which molecular test, if any, would be the most promising to be deployed. This review presents a comprehensive overview of the currently available molecular malaria diagnostics, ranging from well-known tests to platforms in early stages of evaluation, and systematically evaluates their published accuracy. No important difference in accuracy was found between the most commonly used PCR-based assays (conventional, nested and real-time PCR), with most of them having high sensitivity and specificity, implying that there are no reasons other than practical ones to choose one technique over the other. Loop-mediated isothermal amplification and other (novel) diagnostics appear to be highly accurate as well, with some offering potential to be used in resource-limited settings.
DOI: 10.6084/m9.figshare.1568767
title: Development of gene-based markers for the identification of wheat-rye translocations possessing 1RS

description: Wheat-rye translocations carry valuable genes for pest resistance; this has led to their incorporation into wheat varieties. To develop gene-based 1RS specific markers, expressed sequence tags (ESTs) mapped to the short arm of wheat homoeologous group 1 were downloaded from a public database. ESTs and mature transcript sequences of nine species from the Poaceae family were BLASTed to perform comparative analysis. ESTs selected using the BLAST tool were used for primer design. The target sequences of primers were expected to exist in most species of the Poaceae family, and therefore, cross-species primers were designed. Amplicons obtained using these cross-species primer pairs were sequenced in the 1BL.1RS near-isolines (‘OK91G113’ [1BL.1RS] and ‘OK91G114’ [non-translocation]), ‘Chinese Spring’ and ‘Petkus’ rye (1RS donor for 1BL.1RS translocations). Through in silico analysis and primer validation, we were able to develop four 1RS-specific markers and these markers were confirmed with analysis involving 15 1RS translocation lines.
DOI: 10.6084/m9.figshare.1568764
title: The cost of managing severe hypoglycemic episodes in Type 2 diabetic patients

description: Introduction: Hypoglycemia is an acute complication of diabetes that increases morbidity, mortality and disease costs. We aim to estimate healthcare resource consumption and costs associated with severe hypoglycemia using the societal perspective. Methods: A cross-sectional, observational, nationwide, multicenter, hospital-based study was conducted in seven centers of Portuguese mainland with a 1-year enrolment period. Unit costs were extracted from official/public data sources. Patient-level data were used to quantify healthcare resource use related to emergency transportation, emergency-department care and hospitalization. Productivity loss was calculated based on the Human Capital Approach. Results: The study enrolled 238 Type-2 diabetic patients and the proportion of hypoglycemic episodes among all emergency events during the study period was 0.075% (95% CI: 0.067–0.083%). Mean patient age was 76 years and 57.6% were female. At time of the emergency department admission, 55% of patients were using insulin, 31.5% were being treated with secretagogues, 6.7% were on a combination of both, and 6.7% were on other oral antihyperglycemic agents. Estimated mean costs in the emergency department were: emergency transportation €33, medication €4, laboratory workup €56, other exams €72, physician and nurse time €30 and €13, respectively. Mean hospitalization cost was €1271. Indirect cost averaged €15. Overall cost per hypoglycemic episode averaged €1493 (standard deviation: €2962; range: €34–26,818). Patients treated with secretagogues had the highest rates of hospitalizations and mean costs. Conclusion: We conclude that severe hypoglycemic events represent a substantial cost for society and in particular for the hospitals of the National Health Service.
DOI: 10.6084/m9.figshare.1568764.v1
title: The cost of managing severe hypoglycemic episodes in Type 2 diabetic patients

description: Introduction: Hypoglycemia is an acute complication of diabetes that increases morbidity, mortality and disease costs. We aim to estimate healthcare resource consumption and costs associated with severe hypoglycemia using the societal perspective. Methods: A cross-sectional, observational, nationwide, multicenter, hospital-based study was conducted in seven centers of Portuguese mainland with a 1-year enrolment period. Unit costs were extracted from official/public data sources. Patient-level data were used to quantify healthcare resource use related to emergency transportation, emergency-department care and hospitalization. Productivity loss was calculated based on the Human Capital Approach. Results: The study enrolled 238 Type-2 diabetic patients and the proportion of hypoglycemic episodes among all emergency events during the study period was 0.075% (95% CI: 0.067–0.083%). Mean patient age was 76 years and 57.6% were female. At time of the emergency department admission, 55% of patients were using insulin, 31.5% were being treated with secretagogues, 6.7% were on a combination of both, and 6.7% were on other oral antihyperglycemic agents. Estimated mean costs in the emergency department were: emergency transportation €33, medication €4, laboratory workup €56, other exams €72, physician and nurse time €30 and €13, respectively. Mean hospitalization cost was €1271. Indirect cost averaged €15. Overall cost per hypoglycemic episode averaged €1493 (standard deviation: €2962; range: €34–26,818). Patients treated with secretagogues had the highest rates of hospitalizations and mean costs. Conclusion: We conclude that severe hypoglycemic events represent a substantial cost for society and in particular for the hospitals of the National Health Service.
DOI: 10.6084/m9.figshare.1568765.v1
title: Expression of dengue virus NS3 protein in <i>Drosophila</i> alters its susceptibility to infection

description: We developed a <i>Drosophila</i> model in which the dengue virus NS3 protein is expressed in a tissue specific and inducible manner. Dengue virus NS3 is a multifunctional protein playing a major role during viral replication. Both protease and helicase domains of NS3 are interacting with human and insect host proteins including innate immune components of the host machinery. We characterized the NS3 transgenic flies showing that NS3 expression did not affect fly development. To further study the links between NS3 and the innate immune response, we challenge the flies with gram-positive and gram-negative bacteria. Interestingly, the <i>Drosophila</i> transgenic flies expressing NS3 were more susceptible to bacterial infections than control flies. However ubiquitous or immune-specific NS3 expression affected neither the life span nor the response to a non-infectious stress of the flies. In conclusion, we generated a new <i>in vivo</i> system to study the functional impact of DENV NS3 protein on the innate immune response.
DOI: 10.6084/m9.figshare.1568765.v2
title: Expression of dengue virus NS3 protein in <i>Drosophila</i> alters its susceptibility to infection

description: We developed a <i>Drosophila</i> model in which the dengue virus NS3 protein is expressed in a tissue specific and inducible manner. Dengue virus NS3 is a multifunctional protein playing a major role during viral replication. Both protease and helicase domains of NS3 are interacting with human and insect host proteins including innate immune components of the host machinery. We characterized the NS3 transgenic flies showing that NS3 expression did not affect fly development. To further study the links between NS3 and the innate immune response, we challenge the flies with gram-positive and gram-negative bacteria. Interestingly, the <i>Drosophila</i> transgenic flies expressing NS3 were more susceptible to bacterial infections than control flies. However ubiquitous or immune-specific NS3 expression affected neither the life span nor the response to a non-infectious stress of the flies. In conclusion, we generated a new <i>in vivo</i> system to study the functional impact of DENV NS3 protein on the innate immune response.
DOI: 10.6084/m9.figshare.1568765.v3
title: Expression of dengue virus NS3 protein in <i>Drosophila</i> alters its susceptibility to infection

description: We developed a <i>Drosophila</i> model in which the dengue virus NS3 protein is expressed in a tissue specific and inducible manner. Dengue virus NS3 is a multifunctional protein playing a major role during viral replication. Both protease and helicase domains of NS3 are interacting with human and insect host proteins including innate immune components of the host machinery. We characterized the NS3 transgenic flies showing that NS3 expression did not affect fly development. To further study the links between NS3 and the innate immune response, we challenge the flies with gram-positive and gram-negative bacteria. Interestingly, the <i>Drosophila</i> transgenic flies expressing NS3 were more susceptible to bacterial infections than control flies. However ubiquitous or immune-specific NS3 expression affected neither the life span nor the response to a non-infectious stress of the flies. In conclusion, we generated a new <i>in vivo</i> system to study the functional impact of DENV NS3 protein on the innate immune response.
DOI: 10.7925/drs1.duchas_5116388
title: Stories of the Holy Family

description: Story collected by a student at Convent of Mercy, Athlone school (Athlone, Co. Westmeath) from informant Mrs O' Leary.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Sr Regis.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044632
title: Cluain Uaithne Beag

description: A collection of folklore and local history stories from Cluain Uaithne Beag (school) (Shannon Harbour, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Winifred Molloy.
description: Pictures and Sketches -- Findings - Archaeological Notes -- Animal Folklore -- Folklore of the Farm -- Folklore - Clonmacnoise -- Secrets of the Past -- Religious Folklore - St Patrick's Bell -- Historical Folklore -- Archaeological -- Religious Folklore - St Patrick -- Archaeological / Gallchobhair, Séamus Ó -- Holy Wells / Gallchobhair, Brighid Ní -- Folklore of the Farm / Cormaic, Áine Ni -- Folklore of the Farm / Gallcobhair, Eibhlin Ní -- Folklore from Offaly / Gallchobhair, Brighid Ní -- Grand Canal of Long Ago -- Father Stephen Daly's Grave / Cormack, Seosamh Mac -- Offaly Taverns / Cormaic, Máighread Ní -- Here Are a Few Place Names from Trees / Floinn, Máura O -- Historical and Archaeological / Flynn, Máura / Hynes, Séamus / Méara, Eilis Ní / Hynes, Padraig / Lorcáin, Maura Ní / Larkin, Colum Ó / Gallchobhair, Seosamh Ó -- Stone Age / Gallchobhair, Seosamh Ó -- Legends and Customs of Halloween -- History of Grand Canal / Cormhaic, Máighread Ní -- St Brigid Banished the Dead Hand / Meara, Eilis Ní -- Old Story / Gallchobhair, Seosamh Ó -- There is a man in this locality named Martin Rourke, and he once caught a leprechán. / Egan, Marie
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044633
title: Banagher (B.)

description: A collection of folklore and local history stories from Banagher (B.) (school) (Banagher, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Séamus Ó Maoilchéire.
description: My Home District - Banagher -- How the Ass Got His Cross -- How the Robin Got Its Red Breast / Mulhare, James J. -- Our Local Patron Saint -- Old Ruins -- Old Cemetery -- Festival Customs / Mulhare, James J. -- Local Forges -- Local Fairs / Mulhare, James -- Churning -- Leprechaun -- Old Cures -- Potato Crop -- Old Marriage Customs -- Turf-Cutting / Mulhare, James J. -- Footwear -- Crafts -- Old Customs / Mulhare, James J. -- Old Weather Signs / Mulhare, James J. -- Old Riddles / , Schoolboys -- Potato Crop -- Farm Animals / Mulhare, James J. -- Birds / Mulhare, James J. -- Superstitions and Old Beliefs / Mulhare, James J. -- Travelling Folk / Mulhare, James J. -- Old Irish Words still Surviving / Mulhare, James J. -- Food -- Games / Mulhare, James J. -- Proverbs and Old Sayings / Mulhare, James J. -- Fairies -- Fairies in Banagher / Mulhare, James J. -- Ghosts -- Harbour Cross Black Dog -- Weeds and Herbs / Mulhare, James J. -- Garrycastle -- Delvin Eathra -- Maws Castles -- Clonony Castle
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044634
title: Banagher (Parochial)

description: A collection of folklore and local history stories from Banagher (Parochial) (school) (Banagher, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Olive Wilde.
description: Mac Coglans and Garrycastle -- Man and the Devil / Jamieson, Kathleen -- How Banagher Got Its Name / Jamieson, Kathleen -- Haunted Quarry / Jamieson, Kathleen -- Paddy Moran and the Fairies / Jamieson, Kathleen -- Man and the Tower / Jamieson, Kathleen -- Banshee's Comb / Jamieson, Kathleen -- Men and the Pot of Gold / Jamieson, Kathleen
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044635
title: Banagher Convent

description: A collection of folklore and local history stories from Banagher Convent (school) (Banagher, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Sr. Mary Therese.
description: Béaloideas -- Extract from an old book by one of our teachers eight years ago - in 1930.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044636
title: Garbally, Banagher

description: A collection of folklore and local history stories from Garbally, Banagher (school) (Garbally, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher D. Ryder.
description: Hidden Treasure / Brien, Bridgid O -- Riddles / Brien, Bridgid O -- Riddles / Mitchell, Katie -- Fairy Story / Mitchell, Katie -- Riddles / Egan, Annie -- Weather-Lore / Egan, Annie -- A family which it runs in they have only one eye each. / Dolan, John -- There was a man named Tiquin one time who had corn sown at Rapemills. / Dolan, John -- Weather-Lore / Forrester, Micheal -- Big Wind / Forrester, Micheal -- Severe Snow / Forrester, Micheal -- Weather-Lore / Mitchell, Katie -- Local Happenings / Mitchell, Katie -- Story / Brien, Bridgid O -- Fairy Story / Egan, Annie -- Severe Weather / Mitchell, Katie -- Old School / Mitchell, Katie -- Old Schools / Egan, Annie -- Story / Keeffe, Birdget O -- Local Happenings / Brien, Bridgid O -- Famine / Brien, Bridgid O
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044637
title: Bun

description: A collection of folklore and local history stories from Bun (school) (Bun, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher C. Ní Mhaolghuala.
description: My Home District / Guinan, Delia -- Local Patron Saint / Guinan, Maggie -- Broughal Castle / Moore, Joseph -- Festival Customs / Guinan, Bridget -- Local Cures / Guinan, Bridget -- Travelling Folk / Guinan, Bridget -- Local Fairs / Guinan, Bridget -- Food in Former Times / Guinan, Bridget -- Clothes in Former Times / Guinan, Maggie -- Bread / Moore, Joseph -- Houses / Guinan, Bridget -- Herbs / Dolan, Michael -- Weather-Signs / Daly, Lizzie -- Games I Play / Daly, Lizzie -- Birds / Brien, Patrick -- Old Mill / Guinan, Bridget -- Old Schools / Guinan, Bridget -- Potato Crop / Guinan, Bridget -- Local Forges / Guinan, Bridget -- Marriage Customs / Dolan, Michael -- Churning / Guinan, Bridget -- Local Cures / Dolan, Michael -- Old Graveyard / Guinan, Maggie -- Riddles / Guinan, Bridget -- Buying and Selling -- Farm Animals / Guinan, Maggie -- Care of the Feet / Guinan, Bridget -- Famine Times / Guinan, Bridget -- Landlord / Guinan, John -- Old Crafts / Guinan, Bridget -- Leipreachán / Dolan, Michael -- Old Prayers / Moore, Joseph -- Storms / Moore, Joseph -- Local Customs / Guinan, Bridget -- Hidden Treasures / Guinan, Bridget -- Emblems and Objects of Value / Guinan, Bridget -- Proverbs / Guinan, Maggie -- Proverbs -- Old Story / Moore, Joseph -- Story of a Giant / Dolan, Michael / Dolan, Patrick -- Proverbs / Dolan, Michael
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5073347
title: Riddles

description: Story collected by John Mc Donnell, a student at Darver school (Darver, Co. Louth) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher T. Mac Ardghail.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4813847
title: Place Names

description: Story collected by Joseph Synnott, a student at Ballyfasey, Glenmore school (Glenmore, Co. Kilkenny) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Domhnall Mac Cárthaigh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5044638
title: Moneygall

description: A collection of folklore and local history stories from Moneygall (school) (Moneygall, Co. Offaly), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher A. S. Ó Cléirigh.
description: Moneygall is situated in the parish of Dunkerrin and in the barony of Clonlisk. -- How to Make Zam-Buk -- Cure for Hysteria in Dogs - Preventative -- Another Cure for Hysteria in Dogs -- Cure for Lumbago -- Hysteria in Dogs -- Old Cure for Sprain -- Hysteria in Dogs - Preventative -- Pain in Back - Lumbago -- For Cleaning a Dog -- Old Cure to Remove a Swelling -- Rheumatism Cure -- To Revive an Old Dog -- Cure for Cancer -- How to Bring English Acres to Irish Acres -- Hysteria Cure in Dogs -- Sore Eyes in Dogs -- Cures for Mange in Dog -- To Prevent Hysteria in Dogs -- Another Cure for Hysteria in Dogs -- To Prevent a Dog Eating Filth -- To Improve the Appearance of a Motor Hood -- Cure for Mange in Dog -- Rabbits are not in good condition as a food unless in the months of the year which contain an "r". -- Cure for Fits in Dogs -- Cure for Mange in Dog -- Cure for Yellow Jaundice
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.