cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.7564817
title: Dataset related to article "Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes "

description: This record contains raw data related to article “Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes" Abstract <strong>Purpose: </strong> To define predictors of malignancy after Testis sparing surgery (TSS) in patients referring to a fertility center with incidental small testicular lesions. Sub analyses were performed to assess predictors of Leydig cell hyperplasia and Leydig cell tumor. <strong>Materials and methods: </strong> We performed a retrospective analysis of a single institutional database including patients treated with TSS between 2002 and 2020. All patients who underwent TSS as a first line surgical approach for incidentally detected lesions found during fertility evaluation were included. <strong>Results: </strong> Data of 64 patients were collected. The median follow up was 58 months and no recurrences were observed. At univariable logistic regression multifocal lesions, hypervascularization, microlithiasis, age and lesion size were significantly associated with malignancy. At multivariable logistic regression lesion dimension, hypervascularization and multifocal lesions were predictors of malignancy. Lesions smaller than 5 mm proved to be benign in 96.6% of the cases (32/33). Intraoperative color of the lesion and US pattern of vascularization were predictors at multivariable logistic regression for Leydig cell hyperplasia and Leydig cell tumor. <strong>Conclusion: </strong> Ultrasonographic characteristics and intraoperative appearance of the lesion can predict the malignant nature of small testicular lesions, guiding their surgical management in patients referring to a fertility center. Based on our experience, clinicians may safely perform TSS in carefully selected patients.
DOI: 10.5281/zenodo.7564816
title: Dataset related to article "Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes "

description: This record contains raw data related to article “Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes" Abstract <strong>Purpose: </strong> To define predictors of malignancy after Testis sparing surgery (TSS) in patients referring to a fertility center with incidental small testicular lesions. Sub analyses were performed to assess predictors of Leydig cell hyperplasia and Leydig cell tumor. <strong>Materials and methods: </strong> We performed a retrospective analysis of a single institutional database including patients treated with TSS between 2002 and 2020. All patients who underwent TSS as a first line surgical approach for incidentally detected lesions found during fertility evaluation were included. <strong>Results: </strong> Data of 64 patients were collected. The median follow up was 58 months and no recurrences were observed. At univariable logistic regression multifocal lesions, hypervascularization, microlithiasis, age and lesion size were significantly associated with malignancy. At multivariable logistic regression lesion dimension, hypervascularization and multifocal lesions were predictors of malignancy. Lesions smaller than 5 mm proved to be benign in 96.6% of the cases (32/33). Intraoperative color of the lesion and US pattern of vascularization were predictors at multivariable logistic regression for Leydig cell hyperplasia and Leydig cell tumor. <strong>Conclusion: </strong> Ultrasonographic characteristics and intraoperative appearance of the lesion can predict the malignant nature of small testicular lesions, guiding their surgical management in patients referring to a fertility center. Based on our experience, clinicians may safely perform TSS in carefully selected patients.
DOI: 10.6084/m9.figshare.21946637
title: Microplastics in permanent soil observation

description: Within this data repository we stored the research data of a recent manuscript entiteld: <br> <strong>"Microplastics in permanent soil observation samples: Spatial hotspots and temporal variability in soils"</strong> <br> <em>by C.J. Weber, J.E. Bastijans, K. Lügger and C. Heller (2023)</em> <br> <em><strong>More information can be found in the abstract provided below.</strong></em> <br> You fill find two .csv datsets containing sampling area information and microplastic (&gt;300 µm) concentrations. Sample material from permanent soil observation (PSO) areas have been provided by the Hessian State Agency for Nature Conservation, Environment and Geology Boden-Dauerbeobachtung (hlnug.de). <br> Coordinates (Gauß-Krüger, zone 3) of sampling site locations are available as a .txt file. Please note that coorinates have been zeroed in last digit due to data protection of property owners! <br> <strong>Manuscript abstract</strong> <br> <em>Microplastic (MP) contamination of soils has been reported globally and entail a bundle of negative effects on soil functions. However, spatial representative and temporal MP data considering different soils and land uses is lacking globally so far. We used archived topsoil samples from a public authority permanent soil observation programme to investigate spatio-temporal trends of MP contamination on the example of the federal state Hesse (Germany). Within samples covering a time span of maximum 16 years (2003/2004-2014/2015 and 2019), we found widespread MP (&gt;300 µm) contamination (mean 34.66±24.08 p kg-1) from mainly PE and synthetic rubber polymers. Our results show highest MP concentrations in grassland and forest soils against cropland soils. Furthermore, archived soil samples from permanent soil observation programmes enable the identification of spatial contamination hotspots in rural areas and a high variability of MP concentrations over time. No significant temporal trend within MP concentrations could be found. Given the spatial representativeness and independency against MP sources, our results suggest a ubiquitous and independent MP contamination of topsoils, leading to a rough and conservative estimation of 5.92*109 MP particles entailed in agricultural soils in Germany. Based on our results we recommend the usage of archived soil samples for soil related MP research and a treading of current gaps of underrepresented grassland and forest soils.</em>
DOI: 10.5519/qd.pwipocpq
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (5424210 records)
DOI: 10.6084/m9.figshare.21601599
title: Supplementary Material for: Nuclear Factor-κB Clinical Significance in Breast Cancer: An Immunohistochemical Study

description: Objectives: Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key role in cancer genesis and progression. The present study aimed to explore the exact role of NF-κB/p65 as a marker in breast cancer and its relationship with other prognostic markers, such as tumour grade, tumour size, hormone receptors, and HER-2 expression. Methods: Ninety-nine unselected formalin-fixed paraffin-embedded invasive ductal and lobular tissue sections were evaluated by immunohistochemistry methods to measure NF-κB/p65 expression, ER, PR, HER-2 and Ki-67. The correlation between NF-κB/p65 and clinicopathological parameters was assessed. Results: NF-κB/p65 was only found in the cytoplasm and positively correlated with large tumours (≥2 cm) and high-grade tumours (P&lt; 0.001 and P= 0.018, respectively). Other breast cancer markers, such as histological type (P= 0.766), HER-2 (P= 0.416), PR (P= 0.356), and ER (P= 0.606), had no significant link with NF-B/p65 expression. Furthermore, no significant relation with the Ki-67 marker was detected (P= 0.117). Conclusion: The current study discovered a link between NF-κB/p65 overexpression and both large tumour size and higher grade. This might mean that the expression of NF-κB/p65 is associated with aggressive biological activity in breast cancer and that studying the mechanisms that lead to NF-κB/p65 cytoplasmic accumulation could lead to the discovery of novel therapeutic methods.
DOI: 10.6084/m9.figshare.21601599.v1
title: Supplementary Material for: Nuclear Factor-κB Clinical Significance in Breast Cancer: An Immunohistochemical Study

description: Objectives: Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key role in cancer genesis and progression. The present study aimed to explore the exact role of NF-κB/p65 as a marker in breast cancer and its relationship with other prognostic markers, such as tumour grade, tumour size, hormone receptors, and HER-2 expression. Methods: Ninety-nine unselected formalin-fixed paraffin-embedded invasive ductal and lobular tissue sections were evaluated by immunohistochemistry methods to measure NF-κB/p65 expression, ER, PR, HER-2 and Ki-67. The correlation between NF-κB/p65 and clinicopathological parameters was assessed. Results: NF-κB/p65 was only found in the cytoplasm and positively correlated with large tumours (≥2 cm) and high-grade tumours (P&lt; 0.001 and P= 0.018, respectively). Other breast cancer markers, such as histological type (P= 0.766), HER-2 (P= 0.416), PR (P= 0.356), and ER (P= 0.606), had no significant link with NF-B/p65 expression. Furthermore, no significant relation with the Ki-67 marker was detected (P= 0.117). Conclusion: The current study discovered a link between NF-κB/p65 overexpression and both large tumour size and higher grade. This might mean that the expression of NF-κB/p65 is associated with aggressive biological activity in breast cancer and that studying the mechanisms that lead to NF-κB/p65 cytoplasmic accumulation could lead to the discovery of novel therapeutic methods.
DOI: 10.5517/ccdc.csd.cc25nqrb
title: CCDC 2015922: Experimental Crystal Structure Determination

description: Related Article: Katharina Hanau, Sebastian Schwan, Moritz R. Schäfer, Marius J. Müller, Christof Dues, Niklas Rinn, Simone Sanna, Sangam Chatterjee, Doreen Mollenhauer, Stefanie Dehnen|2021|Angew.Chem.,Int.Ed.|60|1176|doi:10.1002/anie.202011370
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25nqsc
title: CCDC 2015923: Experimental Crystal Structure Determination

description: Related Article: Katharina Hanau, Sebastian Schwan, Moritz R. Schäfer, Marius J. Müller, Christof Dues, Niklas Rinn, Simone Sanna, Sangam Chatterjee, Doreen Mollenhauer, Stefanie Dehnen|2021|Angew.Chem.,Int.Ed.|60|1176|doi:10.1002/anie.202011370
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc24xdt9
title: CCDC 1993511: Experimental Crystal Structure Determination

description: Related Article: Wei Shu, Lou Shi|2021|Synlett|32|1479|doi:10.1055/a-1478-2280
description: Related Article: Lou Shi, Ling‐Ling Xing, Wen‐Bo Hu, Wei Shu|2021|Angew.Chem.,Int.Ed.|60|1599|doi:10.1002/anie.202011339
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25nqtd
title: CCDC 2015924: Experimental Crystal Structure Determination

description: Related Article: Katharina Hanau, Sebastian Schwan, Moritz R. Schäfer, Marius J. Müller, Christof Dues, Niklas Rinn, Simone Sanna, Sangam Chatterjee, Doreen Mollenhauer, Stefanie Dehnen|2021|Angew.Chem.,Int.Ed.|60|1176|doi:10.1002/anie.202011370
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25nqvf
title: CCDC 2015925: Experimental Crystal Structure Determination

description: Related Article: Katharina Hanau, Sebastian Schwan, Moritz R. Schäfer, Marius J. Müller, Christof Dues, Niklas Rinn, Simone Sanna, Sangam Chatterjee, Doreen Mollenhauer, Stefanie Dehnen|2021|Angew.Chem.,Int.Ed.|60|1176|doi:10.1002/anie.202011370
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25pgx8
title: CCDC 2016640: Experimental Crystal Structure Determination

description: Related Article: Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich|2021|Angew.Chem.,Int.Ed.|60|2939|doi:10.1002/anie.202011298
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25pgy9
title: CCDC 2016641: Experimental Crystal Structure Determination

description: Related Article: Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich|2021|Angew.Chem.,Int.Ed.|60|2939|doi:10.1002/anie.202011298
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25pgzb
title: CCDC 2016642: Experimental Crystal Structure Determination

description: Related Article: Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich|2021|Angew.Chem.,Int.Ed.|60|2939|doi:10.1002/anie.202011298
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25sk2m
title: CCDC 2019590: Experimental Crystal Structure Determination

description: Related Article: Ouldouz Ghashghaei, Marina Pedrola, Francesca Seghetti, Victor V. Martin, Ricardo Zavarce, Michal Babiak, Jiri Novacek, Frederick Hartung, Katharina M. Rolfes, Thomas Haarmann‐Stemmann, Rodolfo Lavilla|2021|Angew.Chem.,Int.Ed.|60|2603|doi:10.1002/anie.202011253
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25sk7s
title: CCDC 2019595: Experimental Crystal Structure Determination

description: Related Article: Ouldouz Ghashghaei, Marina Pedrola, Francesca Seghetti, Victor V. Martin, Ricardo Zavarce, Michal Babiak, Jiri Novacek, Frederick Hartung, Katharina M. Rolfes, Thomas Haarmann‐Stemmann, Rodolfo Lavilla|2021|Angew.Chem.,Int.Ed.|60|2603|doi:10.1002/anie.202011253
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xq72
title: CCDC 2023594: Experimental Crystal Structure Determination

description: Related Article: Philip Hindenberg, Frank Rominger, Carlos Romero‐Nieto|2021|Angew.Chem.,Int.Ed.|60|766|doi:10.1002/anie.202011368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xq83
title: CCDC 2023595: Experimental Crystal Structure Determination

description: Related Article: Philip Hindenberg, Frank Rominger, Carlos Romero‐Nieto|2021|Angew.Chem.,Int.Ed.|60|766|doi:10.1002/anie.202011368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xq94
title: CCDC 2023596: Experimental Crystal Structure Determination

description: Related Article: Philip Hindenberg, Frank Rominger, Carlos Romero‐Nieto|2021|Angew.Chem.,Int.Ed.|60|766|doi:10.1002/anie.202011368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xqb5
title: CCDC 2023597: Experimental Crystal Structure Determination

description: Related Article: Philip Hindenberg, Frank Rominger, Carlos Romero‐Nieto|2021|Angew.Chem.,Int.Ed.|60|766|doi:10.1002/anie.202011368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25x6lx
title: CCDC 2023109: Experimental Crystal Structure Determination

description: Related Article: Tian‐Zhen Li, Si‐Jia Liu, Yu‐Wen Sun, Shuang Deng, Wei Tan, Yinchun Jiao, Yu‐Chen Zhang, Feng Shi|2021|Angew.Chem.,Int.Ed.|60|2355|doi:10.1002/anie.202011267
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xqc6
title: CCDC 2023598: Experimental Crystal Structure Determination

description: Related Article: Philip Hindenberg, Frank Rominger, Carlos Romero‐Nieto|2021|Angew.Chem.,Int.Ed.|60|766|doi:10.1002/anie.202011368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xqd7
title: CCDC 2023599: Experimental Crystal Structure Determination

description: Related Article: Philip Hindenberg, Frank Rominger, Carlos Romero‐Nieto|2021|Angew.Chem.,Int.Ed.|60|766|doi:10.1002/anie.202011368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xsb7
title: CCDC 2023659: Experimental Crystal Structure Determination

description: Related Article: Ouldouz Ghashghaei, Marina Pedrola, Francesca Seghetti, Victor V. Martin, Ricardo Zavarce, Michal Babiak, Jiri Novacek, Frederick Hartung, Katharina M. Rolfes, Thomas Haarmann‐Stemmann, Rodolfo Lavilla|2021|Angew.Chem.,Int.Ed.|60|2603|doi:10.1002/anie.202011253
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc25xshd
title: CCDC 2023664: Experimental Crystal Structure Determination

description: Related Article: Ouldouz Ghashghaei, Marina Pedrola, Francesca Seghetti, Victor V. Martin, Ricardo Zavarce, Michal Babiak, Jiri Novacek, Frederick Hartung, Katharina M. Rolfes, Thomas Haarmann‐Stemmann, Rodolfo Lavilla|2021|Angew.Chem.,Int.Ed.|60|2603|doi:10.1002/anie.202011253
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc26b8lf
title: CCDC 2035664: Experimental Crystal Structure Determination

description: Related Article: Tian‐Zhen Li, Si‐Jia Liu, Yu‐Wen Sun, Shuang Deng, Wei Tan, Yinchun Jiao, Yu‐Chen Zhang, Feng Shi|2021|Angew.Chem.,Int.Ed.|60|2355|doi:10.1002/anie.202011267
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.