cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3796020.v1
title: Table S2 RNA-seq data

description: Once every menstrual cycle, eggs are ovulated into the oviduct where they await fertilization. The ovulated eggs are arrested in metaphase of the second meiotic division, and only complete meiosis upon fertilization. It is crucial that the maintenance of metaphase arrest is tightly controlled, because the spontaneous activation of the egg would preclude the development of a viable embryo (Zhang <i>et al.</i> 2015 <i>J. Genet. Genomics</i> <b>42</b>, 477–485. (doi:10.1016/j.jgg.2015.07.004); Combelles <i>et al.</i> 2011 <i>Hum. Reprod.</i> <b>26</b>, 545–552. (doi:10.1093/humrep/deq363); Escrich <i>et al.</i> 2011 <i>J. Assist Reprod. Genet.</i> <b>28</b>, 111–117. (doi:10.1007/s10815-010-9493-5)). However, the mechanisms that control the meiotic arrest in mammalian eggs are only poorly understood. Here, we report that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs. As a follow-up of our recent high content RNAi screen for meiotic genes (Pfender <i>et al.</i> 2012 <i>Curr. Biol.</i> <b>21</b>, 955–960. (doi:10.1016/j.cub.2011.04.029)), we identified <i>Btg4</i> as an essential regulator of metaphase II arrest. <i>Btg4-</i>depleted eggs progress into anaphase II spontaneously before fertilization. BTG4 prevents the progression into anaphase by ensuring that the anaphase-promoting complex/cyclosome (APC/C) is completely inhibited during the arrest. The inhibition of the APC/C relies on EMI2 (Tang <i>et al.</i> 2010 <i>Mol. Biol. Cell</i> <b>21</b>, 2589–2597. (doi:10.1091/mbc.E09-08-0708); Ohe <i>et al.</i> 2010 <i>Mol. Biol. Cell</i> <b>21</b>, 905–913. (doi:10.1091/mbc.E09-11-0974)), whose expression is perturbed in the absence of BTG4. BTG4 controls protein expression during metaphase II arrest by forming a complex with the deadenylase and we hypothesize that this complex is recruited to the mRNA via interactions between BTG4 and poly(A)-binding proteins. The BTG4–CAF1 complex drives the shortening of the poly(A) tails of a large number of transcripts at the MI–MII transition, and this wave of deadenylation is essential for the arrest in metaphase II. These findings establish a BTG4-dependent pathway for controlling poly(A) tail length during meiosis and identify an unexpected role for mRNA deadenylation in preventing the spontaneous activation of eggs.
DOI: 10.5281/zenodo.5220575
title: Barley sprout extrction conditions

description: Barley sprout extrction conditions Different anti-obesity effects were shown for each extraction condition. It was evaluated by Oil Red O and TG assay.
DOI: 10.5281/zenodo.5017001
title: Barley sprout extrction conditions

description: Barley sprout extrction conditions Different anti-obesity effects were shown for each extraction condition. It was evaluated by Oil Red O and TG assay.
DOI: 10.6084/m9.figshare.3796062
title: Geolocator positions 2011-2015

description: Midnight and noon positions of Black Guillemots in nonbreeding seasons 2011-2015.
DOI: 10.6084/m9.figshare.3796062.v1
title: Geolocator positions 2011-2015

description: Midnight and noon positions of Black Guillemots in nonbreeding seasons 2011-2015.
DOI: 10.6084/m9.figshare.3796074
title: Wet/dry status Black Guillemots in nonbreeding seasons 2013-2015

description: Percent wet and dry by 4-hour periods for Black Guillemots in nonbreeding seasons 2013-2015.
DOI: 10.6084/m9.figshare.3796074.v1
title: Wet/dry status Black Guillemots in nonbreeding seasons 2013-2015

description: Percent wet and dry by 4-hour periods for Black Guillemots in nonbreeding seasons 2013-2015.
DOI: 10.6084/m9.figshare.3811137
title: Data_Cerebellar_Inpsired_Adaptive_Control_for_Nonlinear_Artificial_Muscle from Cerebellar inspired algorithm for adaptive control of nonlinear dielectric elastomer based artificial muscle

description: Electroactive polymer actuators are important for soft robotics, but can be difficult to control because of compliance, creep, and nonlinearities. Since biological control mechanisms have evolved to deal with such problems, we investigated whether a control scheme based on the cerebellum would be useful for controlling a nonlinear dielectric elastomer actuator, a class of artificial muscle. The cerebellum was represented by the adaptive filter model, and acted in parallel with a brainstem, an approximate inverse plant model. The recurrent connections between the two allowed for direct use of sensory error to adjust motor commands. Accurate tracking of a displacement command in the actuator's nonlinear range was achieved by either semi-linear basis functions in the cerebellar model, or semi-linear functions in the brainstem corresponding to recruitment in biological muscle. In addition, allowing transfer of training between cerebellum and brainstem as has been observed in the vestibulo-ocular reflex prevented the steady increase in cerebellar output otherwise required to deal with creep. The extensibility and relative simplicity of the cerebellar-based adaptive-inverse control scheme suggests it is a plausible candidate for controlling this type of actuator. Moreover, its performance highlights important features of biological control, particularly nonlinear basis functions, recruitment, and transfer of training.
DOI: 10.6084/m9.figshare.3811137.v1
title: Data_Cerebellar_Inpsired_Adaptive_Control_for_Nonlinear_Artificial_Muscle from Cerebellar inspired algorithm for adaptive control of nonlinear dielectric elastomer based artificial muscle

description: Electroactive polymer actuators are important for soft robotics, but can be difficult to control because of compliance, creep, and nonlinearities. Since biological control mechanisms have evolved to deal with such problems, we investigated whether a control scheme based on the cerebellum would be useful for controlling a nonlinear dielectric elastomer actuator, a class of artificial muscle. The cerebellum was represented by the adaptive filter model, and acted in parallel with a brainstem, an approximate inverse plant model. The recurrent connections between the two allowed for direct use of sensory error to adjust motor commands. Accurate tracking of a displacement command in the actuator's nonlinear range was achieved by either semi-linear basis functions in the cerebellar model, or semi-linear functions in the brainstem corresponding to recruitment in biological muscle. In addition, allowing transfer of training between cerebellum and brainstem as has been observed in the vestibulo-ocular reflex prevented the steady increase in cerebellar output otherwise required to deal with creep. The extensibility and relative simplicity of the cerebellar-based adaptive-inverse control scheme suggests it is a plausible candidate for controlling this type of actuator. Moreover, its performance highlights important features of biological control, particularly nonlinear basis functions, recruitment, and transfer of training.
DOI: 10.6084/m9.figshare.14871168
title: FinTech What Should be Taught Really?

description: <i>Accounting and finance professionals aren’t able to possess such skill sets due to the poor design of curriculum at the tertiary levels that do not meet relevant content for the emerging digital age. In this paper we attempt to highlight Finance and Technology (FinTech) content that would be necessary for institutions to consider incorporating into their curriculum to make their graduates FinTech ready. </i>
DOI: 10.6084/m9.figshare.3811164
title: Experimental data from Time-variant species pools shape competitive dynamics and biodiversity–ecosystem function relationships

description: Biodiversity–ecosystem function (BEF) experiments routinely employ common garden designs, drawing samples from a local biota. The communities from which taxa are sampled may not, however, be at equilibrium. To test for temporal changes in BEF relationships, I assembled the pools of aquatic bacterial strains isolated at different time points from leaves on the pitcher plant <i>Darlingtonia californica</i> in order to evaluate the strength, direction and drivers of the BEF relationship across a natural host-associated successional gradient. I constructed experimental communities using bacterial isolates from each time point and measured their respiration rates and competitive interactions. Communities assembled from mid-successional species pools showed the strongest positive relationships between community richness and respiration rates, driven primarily by linear additivity among isolates. Diffuse competition was common among all communities but greatest within mid-successional isolates. These results demonstrate the dependence of the BEF relationship on the temporal dynamics of the local species pool, implying that ecosystems may respond differently to the addition or removal of taxa at different points in time during succession.
DOI: 10.6084/m9.figshare.3811164.v1
title: Experimental data from Time-variant species pools shape competitive dynamics and biodiversity–ecosystem function relationships

description: Biodiversity–ecosystem function (BEF) experiments routinely employ common garden designs, drawing samples from a local biota. The communities from which taxa are sampled may not, however, be at equilibrium. To test for temporal changes in BEF relationships, I assembled the pools of aquatic bacterial strains isolated at different time points from leaves on the pitcher plant <i>Darlingtonia californica</i> in order to evaluate the strength, direction and drivers of the BEF relationship across a natural host-associated successional gradient. I constructed experimental communities using bacterial isolates from each time point and measured their respiration rates and competitive interactions. Communities assembled from mid-successional species pools showed the strongest positive relationships between community richness and respiration rates, driven primarily by linear additivity among isolates. Diffuse competition was common among all communities but greatest within mid-successional isolates. These results demonstrate the dependence of the BEF relationship on the temporal dynamics of the local species pool, implying that ecosystems may respond differently to the addition or removal of taxa at different points in time during succession.
DOI: 10.6084/m9.figshare.3822330
title: Raw Data Behaviour from Can horses read emotional cues from human faces? Re-analysis of Smith et al. (2016)

description: Raw Data Behaviour
DOI: 10.6084/m9.figshare.3822336
title: Raw Data Heart Rate from Can horses read emotional cues from human faces? Re-analysis of Smith et al. (2016)

description: Raw Data Heart Rate
DOI: 10.6084/m9.figshare.3822336.v1
title: Raw Data Heart Rate from Can horses read emotional cues from human faces? Re-analysis of Smith et al. (2016)

description: Raw Data Heart Rate
DOI: 10.6084/m9.figshare.3822339
title: R script of re-analysis from Can horses read emotional cues from human faces? Re-analysis of Smith et al. (2016)

description: R script of re-analysis
DOI: 10.6084/m9.figshare.3822339.v1
title: R script of re-analysis from Can horses read emotional cues from human faces? Re-analysis of Smith et al. (2016)

description: R script of re-analysis
DOI: 10.5281/zenodo.5220668
title: Italian data for the SDGs

description: This dataset shows normalized data related to indicators available on Istat related to Italian regions.
DOI: 10.5281/zenodo.5220667
title: Italian data for the SDGs

description: This dataset shows normalized data related to indicators available on Istat related to Italian regions.
DOI: 10.5281/zenodo.5220238
title: Ovitrap Index JL

description: Ovitrap Index Data for Aedes larvae for dengue outbreak control
DOI: 10.5281/zenodo.5220237
title: Ovitrap Index JL

description: Ovitrap Index Data for Aedes larvae for dengue outbreak control
DOI: 10.17894/ucph.12c38bb6-9dbe-4708-b894-e224ac1e3232
title: test5
DOI: 10.6084/m9.figshare.15262281
title: Supplementary Material for: Topotecan plus Platinum-Based Chemotherapy versus Etoposide plus Platinum-Based Chemotherapy for Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

description: <b><i>Background:</i></b> Whether topotecan plus platinum-based chemotherapy (TP) can achieve better results than etoposide plus platinum-based chemotherapy (EP) for small-cell lung cancer (SCLC) treatment is still controversial in clinical applications. We compared the effectiveness and toxicity of TP versus EP in this meta-analysis. <b><i>Methods:</i></b> We searched PubMed, ScienceDirect, Cochrane Library, Scopus, Ovid MEDLINE, Embase, Web of Science, and Google Scholar databases for completeness one by one to find articles that met the conditions. Overall survival (OS) and progression-free survival (PFS) were analyzed as primary endpoints, and the objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were analyzed as secondary endpoints. <b><i>Results:</i></b> In total, 2,480 articles were retrieved, and 6 randomized controlled trials (RCTs) contained results based on 1,924 patients. EP suggested conspicuously better OS (hazard ratio [HR]: 1.24 [1.02, 1.50], <i>p</i> = 0.03) and PFS (HR: 1.39 [1.17, 1.64], <i>p</i> = 0.0001) in SCLC treatment than TP, and ORR (54.1% vs. 60.2%, risk ratio [RR]: 0.77 [0.57, 1.06], <i>p</i> = 0.11), and DCR (74.9% vs. 84.4%, RR: 0.89 [0.79, 1.00], <i>p</i> = 0.06) tended to favor EP. Subgroup analysis of subsistence showed that EP had prominent benefit in the following subgroups: Asian, median age &gt; 60, first-line treatment, ECOG 0–2, intravenous topotecan, and cisplatin. AEs illustrated that EP had conspicuously more anemia and alopecia than TP. <b><i>Conclusions:</i></b> Compared with TP, EP was noticeably better in OS and PFS, but EP was toxic in terms of anemia and alopecia. More multicenter, better planned RCTs are needed.
DOI: 10.5281/zenodo.5220636
title: Seafloor output from the MEDUSA model

description: - Output from the MEDUSA model (Yool et al., GMD, 2013) - NEMO resolution 1/12-degree - REGRID versions are regridded from ORCA0083 grid to a regular 1/12-degree grid - Simulation performed as part of core NOC activities - Forced under version 5.2 of the DRAKKAR observation-based reanalysis dataset (DFS) - Physical simulation described in Kelly, S. J., Popova, E., Aksenov, Y., Marsh, R., & Yool, A. (2020). They came from the Pacific: How changing Arctic currents could contribute to an ecological regime shift in the Atlantic Ocean. Earth's Future, 8, e2019EF001394. https://doi.org/10.1029/2019EF001394 - Subset of output prepared for Mission Atlantic project by A. Yool in August 2021 - Seafloor fields of model properties for the periods 2006-2015 - Note that this is test output produced for a specific purpose - The output has been regridded to a regular 1/12-degree grid
description: THIS IS TEST OUTPUT
DOI: 10.6084/m9.figshare.15263658
title: Supplementary Material for: Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review

description: <b><i>Introduction:</i></b> Long-term effects of early hyperglycemia in VLBW infants are poorly characterized. The objective of this study was to systematically review the effect of early hyperglycemia on growth, metabolic health, and neurodevelopment after neonatal intensive care unit discharge in VLBW infants. <b><i>Methods:</i></b> The systematic review was conducted in accordance with the PRISMA guidelines. A study protocol was registered in PROSPERO (CRD42019123335). Data sources included Ovid MEDLINE, Embase, Cochrane Library, CINAHL, and Scopus. Selected studies included infants with a blood glucose concentration &gt;150 mg/dL (8.3 mmol/L) during the first 28 days of life, a gestational age (GA) &lt;32 weeks, and/or a birth weight &lt;1,500 g and longitudinal data on growth, metabolic health, or neurodevelopment outcomes. The GRADE system was used to assess quality of evidence. <b><i>Results:</i></b> Eight studies (<i>n</i> = 987 infants) reported long-term outcomes from 4-month corrected GA to 7 years old. Most studies compared long-term outcomes of preterm infants with and without hyperglycemia. Two studies addressed outcomes related to interventions following early hyperglycemia. Some studies found differences in growth, metabolic health, and neurodevelopment outcomes between VLBW preterm infants with hyperglycemia and without hyperglycemia, while other studies found no differences between groups. The overall graded quality of evidence was low. <b><i>Conclusions:</i></b> Well-designed randomized controlled and prospective studies are necessary to determine the effect of early hyperglycemia and its treatment on later metabolic and neurodevelopmental outcomes in VLBW infants. Authors propose a potential study design for standardizing the assessment of long-term metabolic and neurodevelopmental outcomes following early hyperglycemia in preterm infants.
DOI: 10.6084/m9.figshare.15263673
title: Supplementary files

description: Date here including sequencing data which aim to find the effects of different body condition score on liver transcriptomes of transition cows.
DOI: 10.6084/m9.figshare.15263673.v1
title: Supplementary files

description: Date here including sequencing data which aim to find the effects of different body condition score on liver transcriptomes of transition cows.
DOI: 10.6084/m9.figshare.15263679
title: Supplementary Material for: Legacy of a 10-Year Multidomain Lifestyle Intervention on the Cognitive Trajectories of Individuals with Overweight/Obesity and Type 2 Diabetes Mellitus

description: <b><i>Introduction:</i></b> Weight loss and increased physical activity interventions are commonly recommended for individuals with type 2 diabetes (T2D) and overweight or obesity. We examined the impact of randomization to an intensive lifestyle intervention (ILI) on trajectories of cognitive function over 10 years in a cohort of participants in a randomized clinical trial who had T2D and overweight/obesity at baseline. <b><i>Methods:</i></b> Participants aged 45–76 years were enrolled in 2001–2004 and were randomized to the ILI or a diabetes support and education (DSE) condition. Cognitive function was assessed in 3,938 participants at up to 4 time points 8–18 years after randomization. General linear mixed effects models examined cognitive trajectories over time. Subgroup analyses focused on sex, individuals with baseline body mass index &gt;30, those carrying the <i>APOE</i> ε4 allele, and those with a baseline history of cardiovascular disease (CVD). <b><i>Results:</i></b> Overall, there were no differences in the rate of cognitive decline by intervention arm. Subgroup analyses showed that participants who had a baseline history of CVD and were randomized to the ILI arm of the study performed significantly worse on the Stroop Color Word Test than those in the DSE arm. <b><i>Discussion/Conclusions:</i></b> The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.
DOI: 10.6084/m9.figshare.15263679.v1
title: Supplementary Material for: Legacy of a 10-Year Multidomain Lifestyle Intervention on the Cognitive Trajectories of Individuals with Overweight/Obesity and Type 2 Diabetes Mellitus

description: <b><i>Introduction:</i></b> Weight loss and increased physical activity interventions are commonly recommended for individuals with type 2 diabetes (T2D) and overweight or obesity. We examined the impact of randomization to an intensive lifestyle intervention (ILI) on trajectories of cognitive function over 10 years in a cohort of participants in a randomized clinical trial who had T2D and overweight/obesity at baseline. <b><i>Methods:</i></b> Participants aged 45–76 years were enrolled in 2001–2004 and were randomized to the ILI or a diabetes support and education (DSE) condition. Cognitive function was assessed in 3,938 participants at up to 4 time points 8–18 years after randomization. General linear mixed effects models examined cognitive trajectories over time. Subgroup analyses focused on sex, individuals with baseline body mass index &gt;30, those carrying the <i>APOE</i> ε4 allele, and those with a baseline history of cardiovascular disease (CVD). <b><i>Results:</i></b> Overall, there were no differences in the rate of cognitive decline by intervention arm. Subgroup analyses showed that participants who had a baseline history of CVD and were randomized to the ILI arm of the study performed significantly worse on the Stroop Color Word Test than those in the DSE arm. <b><i>Discussion/Conclusions:</i></b> The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.
DOI: 10.6084/m9.figshare.15262728.v1
title: Source-data Johann et al..xlsx

description: <b>Therapeutic </b><b>melanoma inhibition by local micelle-mediated cyclic nucleotide repression</b><b></b> <br>Source data underlying Figures and Supplementary Figures <br>
DOI: 10.6084/m9.figshare.15262728
title: Source-data Johann et al..xlsx

description: <b>Therapeutic </b><b>melanoma inhibition by local micelle-mediated cyclic nucleotide repression</b><b></b> <br>Source data underlying Figures and Supplementary Figures <br>
DOI: 10.6084/m9.figshare.15263760
title: Data simulations above 100m-long irregular ground from Oscillations make a self-scaled model for honeybees' visual odometer reliable regardless of flight trajectory

description: Simulations' data above 100m-long irregular ground under various parametric conditions.
DOI: 10.6084/m9.figshare.15263760.v1
title: Data simulations above 100m-long irregular ground from Oscillations make a self-scaled model for honeybees' visual odometer reliable regardless of flight trajectory

description: Simulations' data above 100m-long irregular ground under various parametric conditions.
DOI: 10.5258/soton/d1750
title: Study into the spread of heat from thermo-optic silicon photonic elements

description: Dataset to support article in Journal: Optics Express. Experimentally characterized and simulated data for heat spread from a heating element in Silicon photonics based Thermo-optics Phase shifter. https://doi.org/10.1364/OE.426748
DOI: 10.5258/soton/d1902
title: Data suppporting "Acetonitrile-free organic electrolyte for textile supercapacitor applications"

description: Dataset supporting the article: "Acetonitrile-free organic electrolyte for textile supercapacitor applications", published in Journal of the Electrochemical Society
DOI: 10.26126/intervals.dirzo8
title: Determination of carbonyls and nicotine concentrations in aqueous extracts [Individual measurements] 

description: This dataset was generated in an in vitro systems toxicology study where the impact of exposure to aqueous extract (AE) of tobacco heating system (THS) 2.2 aerosol was investigated on processes implicated in vascular pathomechanisms and compared to that of 3R4F cigarette smoke (CS) AE.
The levels of selected carbonyls and nicotine were measured in aqueous extracts. This dataset includes single measurements for each sample.
DOI: 10.26126/intervals.bgmjv2
title: Determination of the concentration of inflammatory cytokines released in the basal medium [Individual measurements] 

description: This dataset was generated in an in vitro systems toxicology study where the impact of exposure to aqueous extract (AE) of tobacco heating system (THS) 2.2 aerosol was investigated on processes implicated in vascular pathomechanisms and compared to that of 3R4F cigarette smoke (CS) AE.
The concentration of selected inflammatory mediators released by the organotypic tissues in the culture medium measured using Milliplex panels (Merck Millipore) with Luminex® xMAP® Technology (Luminex, Austin, TX, USA). This dataset includes single measurements for each sample.