cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6073/pasta/890cadb59a4c055abf69e76b6e6d51d4
title: Fall 2022 plant monitoring survey -- biomass calculated from shoot height and flowering status of plants in permanent plots at GCE sampling sites 1-10

description: The biomass of plants surveyed in permanent plots at 10 GCE LTER sampling sites in October 2022 was estimated based on allometric relationships between biomass and shoot height and flowering status derived for each site, zone, and species in October 2002 and October 2008. Biomass was calculated for dominant species, including Spartina alterniflora, S. cynosuroides, Juncus roemerianus, and Zizaniopsis miliacea, as well as rarer species including Scirpus spp, Panicum spp. And Typha angustifolia. This data set is based on GCE plant monitoring survey data set PLT-GCEM-2111a, and allometric relationships were based on GCE data sets PLT-GCEM-0211b, PLT-GCEM-0711, and PLT-GCEM-2011.
DOI: 10.34740/kaggle/dsv/7673424
title: Forex Exchange Rates Since 2004 (Updated Daily)
DOI: 10.6073/pasta/7d1b2e75654af684f8e23aa77603bf5a
title: GCE-LTER Altamaha River Plant Community Monitoring Survey in October 2022

description: A quadrat survey was conducted in October 2022 to measure the species and size distribution of plants at 3 sampling sites on the creekbank of the Altamaha River. The sites were chosen to capture the transition from Spartina alterniflora to Spartina cynosuroides (site SCSA) and the transition from Spartina cynosuroides to Zizaniopsis miliacea (sites ZSC1 and ZSC2). The quadrats were established as permanent plots in October 2012 by placing PVC stakes along the creekbank at each site. Plots were evenly spaced, but were not randomly located because the goal was to start with mixtures of vegetation in most of the plots, and vegetation was distributed in patches along the creekbanks. Therefore, these plots provide useful measures of vegetation change, but are not a random sample of the vegetation at the site. Plots will be replaced each year as necessary to replace any lost to disturbance. The plots were visually surveyed and the species, shoot height, and flowering status was recorded individually for each shoot over 10 cm in height present in each plot. Observations from plots exhibiting signs of disturbance were noted in a separate data set. This survey will be repeated annually to assess changes in plant distribution and biomass in relation to environmental changes documented by other GCE LTER monitoring efforts.
DOI: 10.25345/c5xg9fn6x
title: MassIVE MSV000094143 - Alterations in solubility reveal proteins impacted by aging and impaired proteostasis
title: Detergent-insoluble proteins obtained from the hippocampus and cortex of C57 mice are compared between young (15 weeks, n = 15) and old (100 weeks, n =13) mice.
DOI: 10.5281/zenodo.10689574
title: Wormbiome - Consensus database

description: This is the master consensus database of the Wormbiome genome collection.This tab-delimited file contains the curated annotations from all the bacteria present in the database.

The Wormbiome collection is an online database dedicated to centralizing all the information related to bacteria associated with C. elegans. More information on wormbiome.org.
DOI: 10.5281/zenodo.10689575
title: Wormbiome - Consensus database

description: This is the master consensus database of the Wormbiome genome collection.This tab-delimited file contains the curated annotations from all the bacteria present in the database.

The Wormbiome collection is an online database dedicated to centralizing all the information related to bacteria associated with C. elegans. More information on wormbiome.org.
DOI: 10.5281/zenodo.10685364
title: Dataset for "Optimizing Drought Assessment for Soil Moisture Deficits"

description: Dataset for the paper, "Optimizing Drought Assessment for Soil Moisture Deficits" by Hoylman et al.
DOI: 10.5281/zenodo.10685365
title: Dataset for "Optimizing Drought Assessment for Soil Moisture Deficits"

description: Dataset for Optimizing Drought Assessment for Soil Moisture Deficits
DOI: 10.6069/uwlswd.q8qv-nz89
title: Electronic resource: specific material designation
title: MARC21 007/01 values for electronic resources expressed using RDF

description: Special class of material (usually the class of physical
 object) to which an item belongs (e.g., a magnetic disk).
DOI: 10.6069/uwlswd.cajb-2y62
title: Globe: color
title: MARC21 007/03 values for globes expressed using RDF

description: Whether the globe is in one color or
 multicolored.
DOI: 10.5281/zenodo.6370314
title: Dataset of UAV thermal video sequences with annotations for MOTS benchmarking

description: Instance segmentation dataset created for the research 'Monitoring Mammalian Herbivores via Convolutional Neural Networks implemented on Thermal UAV imagery'. It comprises 959 frames, 20.647 masks, and 239 tracks, and consists of 7 video sequences depicting aerial thermal imagery of cattle collected with a UAV (Parrot ANAFI Thermal) in two outdoor farms in the Netherlands. Data were acquired at three temperatures (10ºC, 19ºC, and 26.5ºC), under sunny and overcast weather conditions, at various angles of inclination (including nadir), and at heights ranging between 8-28 meters. Ground truth was labeled manually with the Computer Vision Annotation Tool CVAT.
DOI: 10.5281/zenodo.6370315
title: Dataset of UAV thermal video sequences with annotations for MOTS benchmarking

description: Instance segmentation dataset created for the research 'Monitoring Mammalian Herbivores via Convolutional Neural Networks implemented on Thermal UAV imagery'. It comprises 959 frames, 20.647 masks, and 239 tracks, and consists of 7 video sequences depicting aerial thermal imagery of cattle collected with a UAV (Parrot ANAFI Thermal) in two outdoor farms in the Netherlands. Data were acquired at three temperatures (10ºC, 19ºC, and 26.5ºC), under sunny and overcast weather conditions, at various angles of inclination (including nadir), and at heights ranging between 8-28 meters. Ground truth was labeled manually with the Computer Vision Annotation Tool CVAT.
DOI: 10.6069/uwlswd.db6k-dw63
title: Globe: physical medium
title: MARC21 007/04 values for globes expressed using RDF

description: Material out of which the globe is made.
DOI: 10.6069/uwlswd.xrxa-qa70
title: Globe: specific material designation
title: MARC21 007/01 values for globes expressed using RDF

description: Special class of material (usually the class of physical
 object) to which an item belongs, e.g., a celestial globe.
DOI: 10.6084/m9.figshare.25260847.v1
title: MHC.vcf.gz

description: human MHC
DOI: 10.6069/uwlswd.3x83-se08
title: Globe: type of reproduction
title: MARC21 007/05 values for globes expressed using RDF

description: Whether the globe is a facsimile or other type of
 reproduction.
DOI: 10.6084/m9.figshare.20324326
title: Xuezhikang alleviates lipid accumulation via AMPK activation in hepatocellular steatosis model

description: Abstract Xuezhikang (XZK) is an extract of Chinese red yeast rice. It has multiple protective effects in cardiovascular systems. However, the underlying mechanism by which XZK affects free fatty acid (FFA)-induced lipogenesis in hepatocellular steatosis model is still unknown. Herein, we investigated this mechanism in HepG2 cells. The HepG2 cells were treated with palmitate acid (PA) to induce lipogenesis. Then the PA-induced HepG2 cells were subsequently treated with XZK. After 24 h of treatment, we determined the intracellular triglyceride (TG) contents and average areas of lipid droplets. To study the involvement of AMPK signaling pathway, we pre-treated the PA-induced HepG2 cells with Compound C, an AMPK inhibitor, before XZK treatment. Expressions of p-AMPK and AMPK were determined by Western blot. The results showed that XZK decreased TG content and lipid accumulation in hepatocellular steatosis model. Compound C abolished the effects of XZK. These results demonstrated for the first time that XZK protects hepatocytes against lipid accumulation induced by free fatty acids. Its effects may be mediated by the activation of AMPK pathway.
DOI: 10.6084/m9.figshare.20324326.v1
title: Xuezhikang alleviates lipid accumulation via AMPK activation in hepatocellular steatosis model

description: Abstract Xuezhikang (XZK) is an extract of Chinese red yeast rice. It has multiple protective effects in cardiovascular systems. However, the underlying mechanism by which XZK affects free fatty acid (FFA)-induced lipogenesis in hepatocellular steatosis model is still unknown. Herein, we investigated this mechanism in HepG2 cells. The HepG2 cells were treated with palmitate acid (PA) to induce lipogenesis. Then the PA-induced HepG2 cells were subsequently treated with XZK. After 24 h of treatment, we determined the intracellular triglyceride (TG) contents and average areas of lipid droplets. To study the involvement of AMPK signaling pathway, we pre-treated the PA-induced HepG2 cells with Compound C, an AMPK inhibitor, before XZK treatment. Expressions of p-AMPK and AMPK were determined by Western blot. The results showed that XZK decreased TG content and lipid accumulation in hepatocellular steatosis model. Compound C abolished the effects of XZK. These results demonstrated for the first time that XZK protects hepatocytes against lipid accumulation induced by free fatty acids. Its effects may be mediated by the activation of AMPK pathway.
DOI: 10.6073/pasta/2ce31d46b58323fdd3eefe1567478873
title: Seagrass Epiphyte Accumulation for Florida Bay, South Florida (FCE) from December 2000 to September 2001

description: Total epiphyte and epiphyte chlorophyll-a loads were measured from artificial seagrass leaves (Mylar) deployed for periods up to the approximate Thalassia leaf turnover period.
DOI: 10.6084/m9.figshare.23060765.v1
title: Concatenated alignments

description: Concatenated alignment files in phylip format. 
When using this data, cite:
<br>
DOI: 10.34740/kaggle/dsv/7673457
title: Full TMDB Movies Dataset 2024 (985K Movies)
DOI: 10.34740/kaggle/dsv/7673468
title: Top Spotify Songs in 73 Countries (Daily Updated)
DOI: 10.34740/kaggle/dsv/7673476
title: Balochi Language to English Translation Dataset
DOI: 10.5281/zenodo.8290803
title: MLKL overexpression in Nuro-2a cells leads to physio-metabolic alterations resembling cellular hallmarks of aginng

description: The necroptotic protein MLKL accumulates in neurons over the lifespan, and their downregulation has the potential to improve cognition through reduced neuroinflammation and changes in the abundance of synaptic proteins and enzymes in brain tissue. Notwithstanding, direct evidence of cell-autonomous effects of MLKL expression on neuronal physiology and metabolism are still lacking. Here, we test whether the overexpression of MLKL in the neuronal cell line Neuro-2a recapitulates some of the hallmarks of aging at the cellular level. Using genetically-encoded fluorescent biosensors, we monitored the cytosolic and mitochondrial calcium levels, along with the cytosolic concentrations of several metabolites involved in energy metabolism (lactate, glucose, ATP), as well as the ratio of oxidized/reduced glutathione as a proxy for oxidative stress. We found that MLKL overexpression leads to reduced cytosolic and mitochondrial Ca2+ elevations in response to selective cell permeabilization to this ion. On the contrary, Ca2+ signals were elevated after mobilizing Ca2+ from the endoplasmic reticulum. Irrespective of the stimulation paradigm, Neuro-2a cells presented higher lactate levels and lower glucose concentrations when overexpressing MLKL, which suggest enhanced neuronal glycolysis. Despite these alterations, energy levels and glutathione redox state in the cell bodies remained largely preserved after inducing MLKL overexpression for 24-48h. At the proteomic level, we found evidence for decreased antioxidant defenses related to protein carbonylation, and increased abundance of molecular chaperones. Taken together, our proof-of-concept experiments are consistent with the hypothesis that MLKL overexpression contributes to both Ca2+ dyshomeostasis and metabolic reprogramming, which are cellular hallmarks of aging.


 
description: This entry contains the Thermo Scientific .raw files for targeted quantitative proteomics experiments carried out on at QEx Plus orbitrap system in the data independent acquisition mode.  
If you have any questions about this experiment, please contact Mike Kinter in the Aging and Metabolism Research Program at the Oklahoma Medical Research Foundation.
DOI: 10.5281/zenodo.8290804
title: MLKL overexpression in Nuro-2a cells leads to physio-metabolic alterations resembling cellular hallmarks of aginng

description: The necroptotic protein MLKL accumulates in neurons over the lifespan, and their downregulation has the potential to improve cognition through reduced neuroinflammation and changes in the abundance of synaptic proteins and enzymes in brain tissue. Notwithstanding, direct evidence of cell-autonomous effects of MLKL expression on neuronal physiology and metabolism are still lacking. Here, we test whether the overexpression of MLKL in the neuronal cell line Neuro-2a recapitulates some of the hallmarks of aging at the cellular level. Using genetically-encoded fluorescent biosensors, we monitored the cytosolic and mitochondrial calcium levels, along with the cytosolic concentrations of several metabolites involved in energy metabolism (lactate, glucose, ATP), as well as the ratio of oxidized/reduced glutathione as a proxy for oxidative stress. We found that MLKL overexpression leads to reduced cytosolic and mitochondrial Ca2+ elevations in response to selective cell permeabilization to this ion. On the contrary, Ca2+ signals were elevated after mobilizing Ca2+ from the endoplasmic reticulum. Irrespective of the stimulation paradigm, Neuro-2a cells presented higher lactate levels and lower glucose concentrations when overexpressing MLKL, which suggest enhanced neuronal glycolysis. Despite these alterations, energy levels and glutathione redox state in the cell bodies remained largely preserved after inducing MLKL overexpression for 24-48h. At the proteomic level, we found evidence for decreased antioxidant defenses related to protein carbonylation, and increased abundance of molecular chaperones. Taken together, our proof-of-concept experiments are consistent with the hypothesis that MLKL overexpression contributes to both Ca2+ dyshomeostasis and metabolic reprogramming, which are cellular hallmarks of aging.


 
description: This entry contains the Thermo Scientific .raw files for targeted quantitative proteomics experiments carried out on at QEx Plus orbitrap system in the data independent acquisition mode.  
If you have any questions about this experiment, please contact Mike Kinter in the Aging and Metabolism Research Program at the Oklahoma Medical Research Foundation.
DOI: 10.5281/zenodo.10689599
title: Effects of limonene-based essential oil on the midgut epithelium of Diatraea saccharalis (Fabricius, 1794) (Lepidoptera: Crambidae) and Spodoptera eridania (Stoll, 1781) (Lepidoptera: Noctuidae) neonate larvae

description: Toxicity data of limonene-based essential oil applied on neonate larvae of Diatraea saccharalis and Spodoptera eridania.
DOI: 10.5281/zenodo.10689600
title: Effects of limonene-based essential oil on the midgut epithelium of Diatraea saccharalis (Fabricius, 1794) (Lepidoptera: Crambidae) and Spodoptera eridania (Stoll, 1781) (Lepidoptera: Noctuidae) neonate larvae

description: Toxicity data of limonene-based essential oil applied on neonate larvae of Diatraea saccharalis and Spodoptera eridania.
DOI: 10.34740/kaggle/dsv/7673508
title: Alcohol Consumption
DOI: 10.25345/c5sq8qv19
title: MassIVE MSV000094144 - Development and crystal structures of a more potent second-generation dual degrader of BCL-2 and BCL-xL
title: Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molecule inhibitors. Here, we determined crystal structures of VHL/753b/BCL-xL and VHL/753b/ BCL-2 ternary complexes. The two ternary complexes exhibit markedly different architectures that are accompanied by distinct networks of interactions at the VHL/PZ753b-linker/target interfaces. The importance of these interfacial contacts was validated via functional analysis and informed subsequent rational and structure-guided design focused on the 753b linker and BCL-2/BCL-xL warhead. This resulted in the design of a novel degrader, WH244, with enhanced potency to degrade BCL-xL/BCL-2 in cells. Using biophysical assays followed by in cell activities, we were able to explain the enhanced target degradation of BCL-2/BCL-xL in cells. Most PROTACs are empirically designed and lack structural studies, making it challenging to understand their modes of action and specificity. Our work presents a streamlined approach that combines rational design and structure-based insights backed with cell-based studies to develop effective PROTAC-based cancer therapeutics.
DOI: 10.34740/kaggle/dsv/7673531
title: Trending Youtube Video Statistics (113 Countries)
DOI: 10.5281/zenodo.10457831
title: Dataset for the Paper: ChatGPT as a Software Development Bot: A Project-based Study

description: This dataset is composed of four sheets:

Entry Survey Questionnaire: This sheet contains 44 survey questions, organized into three major sections, that we asked from students before beginning the developments.Exit Survey Questionnaire: This sheet includes 114 survey questions, organized into five major sections, that we asked from students after three months of development on three projects.Entry Survey Results: This sheet provides the analyzed responses that were collected from the Entry Survey Questionnaire.Exit Survey Results: This sheet provides the analyzed responses that were obtained from the Exit Survey Questionnaire.
DOI: 10.5281/zenodo.10457832
title: Dataset for the Paper: ChatGPT as a Software Development Bot: A Project-based Study

description: This dataset is composed of four sheets:

Entry Survey Questionnaire: This sheet contains 44 survey questions, organized into three major sections, that we asked from students before beginning the developments.Exit Survey Questionnaire: This sheet includes 114 survey questions, organized into five major sections, that we asked from students after three months of development on three projects.Entry Survey Results: This sheet provides the analyzed responses that were collected from the Entry Survey Questionnaire.Exit Survey Results: This sheet provides the analyzed responses that were obtained from the Exit Survey Questionnaire.
DOI: 10.6084/m9.figshare.25262716
title: Stickleback_EvaluatedData.xlsx

description: Excel Sheet, manual analysis, Sticklebacks
DOI: 10.6084/m9.figshare.25262716.v1
title: Stickleback_EvaluatedData.xlsx

description: Excel Sheet, manual analysis, Sticklebacks
DOI: 10.25592/uhhfdm.10062
title: 3D Cuneiform tablet (SUB, Cod.Var.9)

description: 3D Cuneiform tablet (SUB, Cod.Var.9)
description: The research for this 3D object was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy – EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796. The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.
DOI: 10.25592/uhhfdm.10061
title: 3D Cuneiform tablet (SUB, Cod.Var.9)

description: 3D Cuneiform tablet (SUB, Cod.Var.9)
description: The research for this 3D object was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy – EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796. The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.
DOI: 10.25592/uhhfdm.10086
title: 3D Cuneiform tablet (SUB, Cod.Var 2)

description: 3D Cuneiform tablet (SUB, Cod.Var 2)
description: The research for this 3D object was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy – EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796. The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.
DOI: 10.6084/m9.figshare.17704073
title: Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry

description: Alternative splicing in Tau exon 10 generates 3 R- and 4 R-Tau proteoforms, which have equal abundance in healthy adult human brain. Aberrant alternative splicing in Tau exon 10 leads to distortion of the balanced 3 R- and 4 R-Tau expression levels, which is a causal factor to trigger toxic Tau aggregation, neuron dysfunction and patient death in a group of neurodegenerative diseases known as tauopathies. Hence, identification of regulators upstream of the Tau exon 10 splicing events are crucial to understanding pathogenic mechanisms driving tauopathies. In this study, we used RNA Antisense Purification with Mass Spectrometry (RAP-MS) analysis to identify RNA-binding proteins (RBPs) that interact with the Tau pre-mRNA near exon 10. Among the newly identified RBP candidates, we show that knockdown of hnRNPC induces Tau exon 10 skipping whereas overexpression of hnRNPC promotes Tau exon 10 inclusion. In addition, we show that hnRNPC interacts with the poly-uridine (U-tract) sequences in introns 9 and 10 of Tau pre-mRNA. Mutation of these U-tract motifs abolished binding of hnRNPC with Tau pre-mRNA fragment and blocked its impact on Tau exon 10 inclusion. These findings indicate that hnRNPC binds and utilizes these U-tract motifs located in introns 9 and 10 of Tau pre-mRNA to promote Tau exon 10 inclusion. Intriguingly, high hnRNPC expression level is associated with progressive supranuclear palsy (PSP), a sporadic tauopathy with pathological accumulation of Tau species that contain exon 10, which suggests a putative therapeutic role of hnRNPC for PSP treatment.
DOI: 10.25592/uhhfdm.10056
title: 3D Cuneiform tablet (SUB, Cod.Var.11)

description: 3D Cuneiform tablet (SUB, Cod.Var.11)
description: The research for this 3D object was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy – EXC 2176 'Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures', project no. 390893796. The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.