cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6391226
title: Supplementary Material for: Cognitive-Behavioral Analysis System of Psychotherapy, Drug, or Their Combination for Persistent Depressive Disorder: Personalizing the Treatment Choice Using Individual Participant Data Network Metaregression

description: <b><i>Background:</i></b> Persistent depressive disorder is prevalent, disabling, and often difficult to treat. The cognitive-behavioral analysis system of psychotherapy (CBASP) is the only psychotherapy specifically developed for its treatment. However, we do not know which of CBASP, antidepressant pharmacotherapy, or their combination is the most efficacious and for which types of patients. This study aims to present personalized prediction models to facilitate shared decision-making in treatment choices to match patients’ characteristics and preferences based on individual participant data network metaregression. <b><i>Methods:</i></b> We conducted a comprehensive search for randomized controlled trials comparing any two of CBASP, pharmacotherapy, or their combination and sought individual participant data from identified trials. The primary outcomes were reduction in depressive symptom severity for efficacy and dropouts due to any reason for treatment acceptability. <b><i>Results:</i></b> All 3 identified studies (1,036 participants) were included in the present analyses. On average, the combination therapy showed significant superiority over both monotherapies in terms of efficacy and acceptability, while the latter 2 treatments showed essentially similar results. Baseline depression, anxiety, prior pharmacotherapy, age, and depression subtypes moderated their relative efficacy, which indicated that for certain subgroups of patients either drug therapy or CBASP alone was a recommendable treatment option that is less costly, may have fewer adverse effects and match an individual patient’s preferences. An interactive web app (https://kokoro.med.kyoto-u.ac.jp/CBASP/prediction/) shows the predicted disease course for all possible combinations of patient characteristics. <b><i>Conclusions:</i></b> Individual participant data network metaregression enables treatment recommendations based on individual patient characteristics.
DOI: 10.6084/m9.figshare.6391226.v1
title: Supplementary Material for: Cognitive-Behavioral Analysis System of Psychotherapy, Drug, or Their Combination for Persistent Depressive Disorder: Personalizing the Treatment Choice Using Individual Participant Data Network Metaregression

description: <b><i>Background:</i></b> Persistent depressive disorder is prevalent, disabling, and often difficult to treat. The cognitive-behavioral analysis system of psychotherapy (CBASP) is the only psychotherapy specifically developed for its treatment. However, we do not know which of CBASP, antidepressant pharmacotherapy, or their combination is the most efficacious and for which types of patients. This study aims to present personalized prediction models to facilitate shared decision-making in treatment choices to match patients’ characteristics and preferences based on individual participant data network metaregression. <b><i>Methods:</i></b> We conducted a comprehensive search for randomized controlled trials comparing any two of CBASP, pharmacotherapy, or their combination and sought individual participant data from identified trials. The primary outcomes were reduction in depressive symptom severity for efficacy and dropouts due to any reason for treatment acceptability. <b><i>Results:</i></b> All 3 identified studies (1,036 participants) were included in the present analyses. On average, the combination therapy showed significant superiority over both monotherapies in terms of efficacy and acceptability, while the latter 2 treatments showed essentially similar results. Baseline depression, anxiety, prior pharmacotherapy, age, and depression subtypes moderated their relative efficacy, which indicated that for certain subgroups of patients either drug therapy or CBASP alone was a recommendable treatment option that is less costly, may have fewer adverse effects and match an individual patient’s preferences. An interactive web app (https://kokoro.med.kyoto-u.ac.jp/CBASP/prediction/) shows the predicted disease course for all possible combinations of patient characteristics. <b><i>Conclusions:</i></b> Individual participant data network metaregression enables treatment recommendations based on individual patient characteristics.
DOI: 10.6084/m9.figshare.6391145
title: Giroux data.xlsx

description: mean strength of kinaesthetic illusion (from 0 to ten) in the three expérimental conditions (bimodal, proprioception and vision) and for flexion and extension passive displacements. <br>
DOI: 10.6084/m9.figshare.6391145.v1
title: Giroux data.xlsx

description: mean strength of kinaesthetic illusion (from 0 to ten) in the three expérimental conditions (bimodal, proprioception and vision) and for flexion and extension passive displacements. <br>
DOI: 10.6084/m9.figshare.6391124
title: Supplementary Material for: MicroRNAs Associated with Epithelial-Mesenchymal Transition Can Be Targeted to Inhibit Peritoneal Dissemination of Human Scirrhous Gastric Cancers

description: <b><i>Objectives:</i></b> Scirrhous gastric cancers grow rapidly, and frequently invade the peritoneum. Such peritoneal dissemination properties markedly reduce patient survival. Thus, an effective means for inhibiting peritoneal dissemination is urgently required. <b><i>Methods:</i></b> We previously established a cell line, HSC-58, from a scirrhous gastric cancer patient, and further successfully isolated a metastatic line, 58As9, in nude mice upon orthotopic inoculation. Using the lines, we examined the mechanism underlying peritoneal dissemination from the viewpoint of microRNA (miRNA) expression. <b><i>Results:</i></b> miRNA array and qRT-PCR analysis showed that the expressions of epithelial-mesenchymal transition (EMT)-associated miRNAs such as miR-200c and miR-141 were significantly low in 58As9. Using 58As9 with stably overexpressing miR-200c, miR-141, or both, together with a luciferase reporter assay, we found that miR-200c targeted zinc finger E-box-binding homeobox 1 (ZEB1) and miR-141 targeted ZEB2. The overexpressed lines reversed the EMT status from mesenchymal to epithelial in 58As9, and significantly reduced the invasion activity and peritoneal dissemination for a significant prolongation of survival in the orthotopic tumor models in nude mice. <b><i>Conclusions:</i></b> EMT-associated miRNAs such as miR-200c and miR-141 and their target genes ZEB1/ZEB2 have good potential for antiperitoneal dissemination therapy in patients with scirrhous gastric cancers.
DOI: 10.6084/m9.figshare.6390653
title: Supplementary Material for: Diets Supplemented with 1% Egg White Induce Oral Desensitization and Immune Tolerance in an Egg White-Specific Allergic Mouse Model

description: <b><i>Background:</i></b> The objective of this study was to determine the required concentration of egg white (EW) in the diet to induce oral desensitization and/or immune tolerance within 4 weeks of oral immunotherapy (OIT) in an EW allergic mouse model. <b><i>Methods:</i></b> Female BALB/c mice were systemically sensitized to EW by intraperitoneal injections and subsequently subjected to oral allergen gavage. Sensitized mice were provided 4 weeks of OIT by supplementing with 0 (non-OIT), 0.01, 0.1, or 1% EW in a 20% casein diet. Nonsensitized mice served as the nonallergy group. We performed oral and intraperitoneal EW challenges, assessed vascular permeability in the dorsal skin, and measured allergic biomarkers. <b><i>Results:</i></b> The change in rectal temperature after oral challenge was not significantly different between the nonallergy and 1% EW groups, and the frequency of diarrhea in the 1% EW group was lower than that in the non-OIT group. The levels of plasma ovomucoid-specific IgE, IgA, and IgG2a in the 1% EW group at the study endpoint were significantly lower than those in the non-OIT group. IFN-γ and IL-10 secretions of spleen lymphocytes in the 1% EW group were significantly higher than those in the non-OIT group, and the percentage of CD4+Foxp3+ cells in the 1% EW group was higher than that in the non-OIT group. <b><i>Conclusion:</i></b> These results suggested that diet supplemented with 1% EW can induce oral desensitization and immune tolerance in the EW allergic mouse model.
DOI: 10.6084/m9.figshare.6390614
title: Supplementary Material for: Lymphovascular Invasion Increases the Risk of Nodal and Distant Recurrence in Node-Negative Stage I–IIA Non-Small-Cell Lung Cancer

description: <b><i>Objectives:</i></b> Despite complete surgical resection, 30–40% of patients with stage I–IIA non-small-cell lung cancer (NSCLC) have recurrences. We aimed to elucidate the effect of lymphovascular invasion (LVI) on the prognosis and patterns of recurrence in patients with pathologically confirmed T1–2N0 NSCLC. <b><i>Methods:</i></b> We evaluated 381 patients who underwent complete resection and were diagnosed with pathologic T1–2N0 NSCLC between March 2000 and January 2012. Local recurrence, nodal recurrence, and distant metastasis were defined and analyzed. <b><i>Results:</i></b> LVI was present in 72 patients (18.9%). The 5-year disease-free survival (DFS) for all patients was 69.9%. Patients with LVI showed a significant decrease in 5-year DFS (47.3 vs. 74.4%, <i>p</i> &lt; 0.001). LVI was a significant prognostic predictor in multivariate analysis (<i>p</i> = 0.003). The patients with LVI showed a significantly increased 5-year cumulative incidence of nodal recurrence (22.5 vs. 8.7%, <i>p</i> &lt; 0.001) and distant metastasis (30.4 vs. 14.9%, <i>p</i> = 0.004). However, no difference was shown between the two groups in the 5-year cumulative incidence of local recurrence (<i>p</i> = 0.416). <b><i>Conclusions:</i></b> LVI is a negative prognostic factor in patients with stage I–IIA NSCLC. The presence of LVI significantly increases the risk of nodal and distant recurrence.
DOI: 10.6084/m9.figshare.6390599
title: Supplementary Material for: In Preterm Infants, Length Growth below Expected Growth during Hospital Stay Predicts Poor Neurodevelopment at 2 Years

description: <b><i>Background:</i></b> In preterm infants, neonatal weight growth is associated with neurodevelopmental outcome but is a poor indicator of growth quality. <b><i>Objective:</i></b> The aim of this work was to measure the relationship between neonatal length growth and the 2-year neurological outcome in preterm infants. <b><i>Methods:</i></b> A total of 2,403 infants enrolled in the LIFT cohort with gestational age less than 34 weeks were studied. Neonatal observed length growth (OLG) was calculated as the change in length <i>Z</i>-score between birth and discharge. Expected length growth (ELG) was estimated based on gestational age, birth weight <i>Z</i>-score, birth length <i>Z</i>-score, gender, and observed neonatal weight growth. The difference between OLG and ELG (∆<sub>OLG-ELG</sub>) was calculated as OLG – ELG, and infants were ranked into 3 classes depending on their ∆<sub>OLG-ELG</sub> (≤–0.5, –0.49 to 0.49, ≥0.50 <i>Z</i>-score). We explored the relationship between ∆<sub>OLG-ELG</sub> and 2-year neurodevelopmental outcome (<i>n</i> = 2,036), and, in a subgroup (<i>n</i> = 85), between ∆<sub>OLG-ELG</sub> and body composition at discharge. <b><i>Results:</i></b> ELG was strongly predicted from the above-mentioned parameters (<i>R</i><sup>2</sup> = 0.73, <i>p</i> = 0.001). OLG correlated closely with gestational age (<i>p</i> = 0.001) but ∆<sub>OLG-ELG</sub> did not (<i>p</i> = 1.0). OLG was not associated with a 2-year nonoptimal outcome after adjustment for gestational age, but ∆<sub>OLG-ELG</sub> ≤–0.5 was; the crude and adjusted odds ratios were 1.63 and 1.56, respectively. ∆<sub>OLG-ELG</sub> correlated negatively with fat mass (<i>R</i><sup>2</sup> = 0.29, <i>p</i> = 0.006) before and after adjustment for gestational age. <b><i>Conclusion:</i></b> ∆<sub>OLG-ELG</sub> is a marker of neonatal growth that does not depend on gestational age, and may reflect quality of growth. A ∆<sub>OLG-ELG</sub> ≤–0.5 <i>Z</i>-score is associated with a higher risk for 2-year nonoptimal neurodevelopmental outcome.
DOI: 10.6084/m9.figshare.6390599.v1
title: Supplementary Material for: In Preterm Infants, Length Growth below Expected Growth during Hospital Stay Predicts Poor Neurodevelopment at 2 Years

description: <b><i>Background:</i></b> In preterm infants, neonatal weight growth is associated with neurodevelopmental outcome but is a poor indicator of growth quality. <b><i>Objective:</i></b> The aim of this work was to measure the relationship between neonatal length growth and the 2-year neurological outcome in preterm infants. <b><i>Methods:</i></b> A total of 2,403 infants enrolled in the LIFT cohort with gestational age less than 34 weeks were studied. Neonatal observed length growth (OLG) was calculated as the change in length <i>Z</i>-score between birth and discharge. Expected length growth (ELG) was estimated based on gestational age, birth weight <i>Z</i>-score, birth length <i>Z</i>-score, gender, and observed neonatal weight growth. The difference between OLG and ELG (∆<sub>OLG-ELG</sub>) was calculated as OLG – ELG, and infants were ranked into 3 classes depending on their ∆<sub>OLG-ELG</sub> (≤–0.5, –0.49 to 0.49, ≥0.50 <i>Z</i>-score). We explored the relationship between ∆<sub>OLG-ELG</sub> and 2-year neurodevelopmental outcome (<i>n</i> = 2,036), and, in a subgroup (<i>n</i> = 85), between ∆<sub>OLG-ELG</sub> and body composition at discharge. <b><i>Results:</i></b> ELG was strongly predicted from the above-mentioned parameters (<i>R</i><sup>2</sup> = 0.73, <i>p</i> = 0.001). OLG correlated closely with gestational age (<i>p</i> = 0.001) but ∆<sub>OLG-ELG</sub> did not (<i>p</i> = 1.0). OLG was not associated with a 2-year nonoptimal outcome after adjustment for gestational age, but ∆<sub>OLG-ELG</sub> ≤–0.5 was; the crude and adjusted odds ratios were 1.63 and 1.56, respectively. ∆<sub>OLG-ELG</sub> correlated negatively with fat mass (<i>R</i><sup>2</sup> = 0.29, <i>p</i> = 0.006) before and after adjustment for gestational age. <b><i>Conclusion:</i></b> ∆<sub>OLG-ELG</sub> is a marker of neonatal growth that does not depend on gestational age, and may reflect quality of growth. A ∆<sub>OLG-ELG</sub> ≤–0.5 <i>Z</i>-score is associated with a higher risk for 2-year nonoptimal neurodevelopmental outcome.
DOI: 10.6084/m9.figshare.6390542
title: Parents attitudes towards different digital media.jpg

description: This table supplements an article for the journal Comunicar with the title: Towards understanding young children’s digital lives in China and Australia
DOI: 10.6084/m9.figshare.6390542.v1
title: Parents attitudes towards different digital media.jpg

description: This table supplements an article for the journal Comunicar with the title: Towards understanding young children’s digital lives in China and Australia
DOI: 10.6084/m9.figshare.6390494
title: Additional file 9: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S9. Functional annotation of genes and transcripts in Ipomoea trifida from Trinotate. (XLSX 10975 kb)
DOI: 10.6084/m9.figshare.6390494.v1
title: Additional file 9: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S9. Functional annotation of genes and transcripts in Ipomoea trifida from Trinotate. (XLSX 10975 kb)
DOI: 10.6084/m9.figshare.6390485
title: Additional file 8: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S8. Functional annotation of genes and transcripts in Ipomoea batatas from Trinotate. (XLSX 12149 kb)
DOI: 10.6084/m9.figshare.6390485.v1
title: Additional file 8: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S8. Functional annotation of genes and transcripts in Ipomoea batatas from Trinotate. (XLSX 12149 kb)
DOI: 10.6084/m9.figshare.6390467
title: Additional file 7: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S7. Genes differentially expressed between storage roots and fine roots of Distimake dissectus. Statistics from edgeR on transcripts found to be significantly differentially expressed between storage roots and fine roots in Distimake dissectus. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.6390467.v1
title: Additional file 7: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S7. Genes differentially expressed between storage roots and fine roots of Distimake dissectus. Statistics from edgeR on transcripts found to be significantly differentially expressed between storage roots and fine roots in Distimake dissectus. (XLSX 23 kb)
DOI: 10.6084/m9.figshare.6390452
title: Additional file 6: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S6. Genes differentially expressed between storage roots and fine roots in Ipomoea batatas. Statistics from edgeR on transcripts found to be significantly differentially expressed between storage roots and fine roots in Ipomoea batatas. (XLSX 142 kb)
DOI: 10.6084/m9.figshare.6390452.v1
title: Additional file 6: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S6. Genes differentially expressed between storage roots and fine roots in Ipomoea batatas. Statistics from edgeR on transcripts found to be significantly differentially expressed between storage roots and fine roots in Ipomoea batatas. (XLSX 142 kb)
DOI: 10.6084/m9.figshare.6390440
title: Additional file 5: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S5. TMM-normalized FPKM values for fine root samples in Distimake quinquefolius. Statistics were output from edgeR analysis. (XLSX 5130 kb)
DOI: 10.6084/m9.figshare.6390440.v1
title: Additional file 5: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S5. TMM-normalized FPKM values for fine root samples in Distimake quinquefolius. Statistics were output from edgeR analysis. (XLSX 5130 kb)
DOI: 10.6084/m9.figshare.6390428
title: Additional file 4: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S4. TMM-normalized FPKM values for fine root samples in Distimake dissectus. Statistics were output from edgeR analysis. (XLSX 4129 kb)
DOI: 10.6084/m9.figshare.6390428.v1
title: Additional file 4: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S4. TMM-normalized FPKM values for fine root samples in Distimake dissectus. Statistics were output from edgeR analysis. (XLSX 4129 kb)
DOI: 10.6084/m9.figshare.6390419
title: Additional file 3: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S3. TMM-normalized FPKM values for fine root samples in Ipomoea trifida. Statistics were output from edgeR analysis. (XLSX 1833 kb)
DOI: 10.6084/m9.figshare.6390419.v1
title: Additional file 3: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S3. TMM-normalized FPKM values for fine root samples in Ipomoea trifida. Statistics were output from edgeR analysis. (XLSX 1833 kb)
DOI: 10.6084/m9.figshare.6390404
title: Additional file 2: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S2. TMM-normalized FPKM values for fine root samples in Ipomoea batatas. Statistics were output from edgeR analysis. (XLSX 4456 kb)
DOI: 10.6084/m9.figshare.6390404.v1
title: Additional file 2: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S2. TMM-normalized FPKM values for fine root samples in Ipomoea batatas. Statistics were output from edgeR analysis. (XLSX 4456 kb)
DOI: 10.6084/m9.figshare.6390392
title: Additional file 1: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S1. Accession information for the plant material used in this experiment. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6390392.v1
title: Additional file 1: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S1. Accession information for the plant material used in this experiment. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6390389
title: Additional file 6: of Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry

description: Table S9. The full name and abbreviation of proteins in Fig.Â 8. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.6390389.v1
title: Additional file 6: of Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry

description: Table S9. The full name and abbreviation of proteins in Fig.Â 8. (XLSX 16 kb)
DOI: 10.6084/m9.figshare.6390377
title: Additional file 5: of Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry

description: Table S8. The full name and abbreviation of proteins listed in Figs.Â 6 andÂ 7. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.6390377.v1
title: Additional file 5: of Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry

description: Table S8. The full name and abbreviation of proteins listed in Figs.Â 6 andÂ 7. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.6390374
title: Additional file 11: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S11. Functional annotation of genes and transcripts in Distimake quinquefolius from Trinotate. (XLSX 23712 kb)
DOI: 10.6084/m9.figshare.6390374.v1
title: Additional file 11: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S11. Functional annotation of genes and transcripts in Distimake quinquefolius from Trinotate. (XLSX 23712 kb)
DOI: 10.6084/m9.figshare.6390362
title: Additional file 4: of Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry

description: Table S7. A list of common differentially expressed genes and differentially expressed proteins in the mammary gland of cows fed corn stover (CS) vs. alfalfa hay (AH). (XLSX 17 kb)
DOI: 10.6084/m9.figshare.6390362.v1
title: Additional file 4: of Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry

description: Table S7. A list of common differentially expressed genes and differentially expressed proteins in the mammary gland of cows fed corn stover (CS) vs. alfalfa hay (AH). (XLSX 17 kb)
DOI: 10.6084/m9.figshare.6390350
title: Additional file 10: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S10. Functional annotation of genes and transcripts in Distimake dissectus from Trinotate. (XLSX 13051 kb)
DOI: 10.6084/m9.figshare.6390350.v1
title: Additional file 10: of Parallel evolution of storage roots in morning glories (Convolvulaceae)

description: Table S10. Functional annotation of genes and transcripts in Distimake dissectus from Trinotate. (XLSX 13051 kb)
DOI: 10.6084/m9.figshare.6390347
title: Additional file 4: of Genome sequencing and protein domain annotations of Korean Hanwoo cattle identify Hanwoo-specific immunity-related and other novel genes

description: Protein sequences which have locations with depthâ &gt;â 10Ă . (XLSX 101 kb)