cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29389097
title: Supplementary Material for: Food insecurity in hidradenitis suppurativa: a cross-sectional analysis from the population-based All of Us Research Program

description: Introduction
Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease associated with obesity and low socioeconomic status that can have a significant impact on quality of life. Food insecurity (FI) is associated with a higher likelihood of having a chronic health condition. This cross-sectional study was undertaken to assess the association between HS and FI.

Methods
We performed secondary analysis of a cross-sectional survey of individuals 18 years and older registered in the National Institutes of Health’s All of Us Research Program in May 2024. The study sample was limited to those who had completed the Children’s HealthWatch Hunger Vital SignTM FI screening survey, validated for use in adults in 2017. HS status was assessed among study participants based on ICD-9/10 diagnosis code (705.83 or L73.2). Multivariable logistic regression was used to characterize the association between HS diagnosis and food security status, adjusting for sex, race and ethnicity, age, and income.

Results
Among participants with HS, 37/134 (27.6%) screened positive for FI. In comparison, among those without HS, 6,278/56,967 (11%) screened positive. In an adjusted multivariable logistic regression, HS was associated with significantly higher odds of FI (OR: 1.70, 95% CI: 1.09-2.60).

Conclusion
Study results demonstrated a significant association between HS and FI. Further research is needed to understand specific factors mediating the relationship between HS and FI. The study highlights an opportunity for dermatologists to take an active role in screening for FI in patients with HS and in providing resources as necessary.
DOI: 10.6084/m9.figshare.29389097.v1
title: Supplementary Material for: Food insecurity in hidradenitis suppurativa: a cross-sectional analysis from the population-based All of Us Research Program

description: Introduction
Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease associated with obesity and low socioeconomic status that can have a significant impact on quality of life. Food insecurity (FI) is associated with a higher likelihood of having a chronic health condition. This cross-sectional study was undertaken to assess the association between HS and FI.

Methods
We performed secondary analysis of a cross-sectional survey of individuals 18 years and older registered in the National Institutes of Health’s All of Us Research Program in May 2024. The study sample was limited to those who had completed the Children’s HealthWatch Hunger Vital SignTM FI screening survey, validated for use in adults in 2017. HS status was assessed among study participants based on ICD-9/10 diagnosis code (705.83 or L73.2). Multivariable logistic regression was used to characterize the association between HS diagnosis and food security status, adjusting for sex, race and ethnicity, age, and income.

Results
Among participants with HS, 37/134 (27.6%) screened positive for FI. In comparison, among those without HS, 6,278/56,967 (11%) screened positive. In an adjusted multivariable logistic regression, HS was associated with significantly higher odds of FI (OR: 1.70, 95% CI: 1.09-2.60).

Conclusion
Study results demonstrated a significant association between HS and FI. Further research is needed to understand specific factors mediating the relationship between HS and FI. The study highlights an opportunity for dermatologists to take an active role in screening for FI in patients with HS and in providing resources as necessary.
DOI: 10.6084/m9.figshare.29389100
title: Supplementary Material for: Acute Antibody-Mediated Rejection Associated with Anti-MICA Antibodies in Long-Term Kidney Transplant: A Case Study

description: Introduction: Advances in immunosuppressive therapy have improved kidney transplant outcomes; however, antibody-mediated rejection (ABMR) still affects graft survival. Herein, we present a case of a 46-year-old woman who experienced acute ABMR despite stable long-term graft function following kidney transplantation. Case Presentation: At 28 years of age, she underwent a blood-type-compatible living kidney transplant from her father. Eighteen years later, she was admitted to the hospital with a fever and sore throat, raising suspicion of a respiratory infection. Given the rapid deterioration of renal function following hospitalisation, a biopsy was conducted. The findings showed diffuse glomerulitis and peritubular capillaritis, along with focal observations of endoarteritis, glomerular thrombi, and interstitial haemorrhage, consistent with active ABMR. She was treated with methylprednisolone pulse therapy and intravenous immunoglobulin, which induced gradual recovery. Screening tests for anti-human leukocyte antigen (HLA) antibodies yielded negative results. However, tests for non-HLA antibodies detected the presence of anti-major histocompatibility complex class I chain-related gene A (MICA) antibodies in the blood sample prior to the onset of rejection. Notably, at the time of rejection, anti-MICA antibodies were not detectable in the blood; nevertheless, they were subsequently found to be positive 10 months later. These antibodies may have been sequestered within tissues, rendering them undetectable in the bloodstream. Conclusion: Anti-MICA antibodies have previously been implicated in ABMR; however, this case highlights their role in late-onset rejection after prolonged graft stability. This case underscores the importance of non-HLA donor-specific antibody tests when ABMR occurs in a recipient lacking anti-HLA antibodies.
DOI: 10.6084/m9.figshare.29389100.v1
title: Supplementary Material for: Acute Antibody-Mediated Rejection Associated with Anti-MICA Antibodies in Long-Term Kidney Transplant: A Case Study

description: Introduction: Advances in immunosuppressive therapy have improved kidney transplant outcomes; however, antibody-mediated rejection (ABMR) still affects graft survival. Herein, we present a case of a 46-year-old woman who experienced acute ABMR despite stable long-term graft function following kidney transplantation. Case Presentation: At 28 years of age, she underwent a blood-type-compatible living kidney transplant from her father. Eighteen years later, she was admitted to the hospital with a fever and sore throat, raising suspicion of a respiratory infection. Given the rapid deterioration of renal function following hospitalisation, a biopsy was conducted. The findings showed diffuse glomerulitis and peritubular capillaritis, along with focal observations of endoarteritis, glomerular thrombi, and interstitial haemorrhage, consistent with active ABMR. She was treated with methylprednisolone pulse therapy and intravenous immunoglobulin, which induced gradual recovery. Screening tests for anti-human leukocyte antigen (HLA) antibodies yielded negative results. However, tests for non-HLA antibodies detected the presence of anti-major histocompatibility complex class I chain-related gene A (MICA) antibodies in the blood sample prior to the onset of rejection. Notably, at the time of rejection, anti-MICA antibodies were not detectable in the blood; nevertheless, they were subsequently found to be positive 10 months later. These antibodies may have been sequestered within tissues, rendering them undetectable in the bloodstream. Conclusion: Anti-MICA antibodies have previously been implicated in ABMR; however, this case highlights their role in late-onset rejection after prolonged graft stability. This case underscores the importance of non-HLA donor-specific antibody tests when ABMR occurs in a recipient lacking anti-HLA antibodies.
DOI: 10.6084/m9.figshare.29389103
title: Supplementary Material for: Enhanced Recovery After Fetal Sequencing: A Perinatal Genomic Scoping Review of Exome / Genome Testing for Reproductive / Obstetric-MFM Providers to initiate Knowledge Translation following a Screening Ultrasound Identifying Fetal Anomalies.

description: Abstract
Introduction: This review of genomic perinatal opportunities and uses will provide counselling and personal genetic knowledge for improved patient care. M/M: This focused systematic analysis and review has used PUBMED keywords to identify genomic testing for ultrasound identified fetal anomaly (ies) that require diagnostic testing after an informed consent process. Results: Multiple fetal anomalies, using TRIO sequencing processes, have a better diagnostic yield, with certain cohorts &gt; 50%. For the single anatomic categories, skeletal, central nervous system, and renal systems, using WES fetal sequencing (most commonly) for a diagnostic result, have the larger incremental diagnostic yield over CMA. Conclusion: The phenotype-genotype (fetal-genomic result) consideration and use of the pES technology can be summarized using a SWOT analysis: strength (enhanced evaluation of fetal-neonatal genomic abnormalities not identified by standard chromosomal microarray and improved ethical care decisions); weakness (the understanding and complexity of genomic pathology and testing / the fiscal cost for professional time and the health system services); opportunity (an increased recognition of fetal genetic risk pathology [de novo or inherited carrier mutations] with improved understanding and knowledge translation of counselling for recurrence risk); threat (inability to provide a genetic diagnosis or interpret a variant of unknown significance or the discovery of incidental findings or unanticipated parental genomic diagnoses).
DOI: 10.6084/m9.figshare.29389103.v1
title: Supplementary Material for: Enhanced Recovery After Fetal Sequencing: A Perinatal Genomic Scoping Review of Exome / Genome Testing for Reproductive / Obstetric-MFM Providers to initiate Knowledge Translation following a Screening Ultrasound Identifying Fetal Anomalies.

description: Abstract
Introduction: This review of genomic perinatal opportunities and uses will provide counselling and personal genetic knowledge for improved patient care. M/M: This focused systematic analysis and review has used PUBMED keywords to identify genomic testing for ultrasound identified fetal anomaly (ies) that require diagnostic testing after an informed consent process. Results: Multiple fetal anomalies, using TRIO sequencing processes, have a better diagnostic yield, with certain cohorts &gt; 50%. For the single anatomic categories, skeletal, central nervous system, and renal systems, using WES fetal sequencing (most commonly) for a diagnostic result, have the larger incremental diagnostic yield over CMA. Conclusion: The phenotype-genotype (fetal-genomic result) consideration and use of the pES technology can be summarized using a SWOT analysis: strength (enhanced evaluation of fetal-neonatal genomic abnormalities not identified by standard chromosomal microarray and improved ethical care decisions); weakness (the understanding and complexity of genomic pathology and testing / the fiscal cost for professional time and the health system services); opportunity (an increased recognition of fetal genetic risk pathology [de novo or inherited carrier mutations] with improved understanding and knowledge translation of counselling for recurrence risk); threat (inability to provide a genetic diagnosis or interpret a variant of unknown significance or the discovery of incidental findings or unanticipated parental genomic diagnoses).
DOI: 10.6084/m9.figshare.29389106
title: Supplementary Material for: A Comparison of Clinical Outcomes in Urgent-Start Hemodialysis vs. Urgent-Start Peritoneal Dialysis in ESRD patients: A Systematic Review and Meta-Analysis

description: Background: USPD is related to fewer complications and lower mortality rates compared to USHD in patients who need renal replacement therapy. However, there is a lack of literature specifically addressing its application and results in individuals with ESRD.
Objective: A comprehensive examination and synthesis of existing research were conducted to compare fellow up outcomes of USPD versus USHD in ESRD patients .
Methods: A comprehensive search was conducted in PubMed, Web of Science, and the Cochrane Library, and SpringerLink databases for that compare urgent-start PD to urgent-start HD before November 1th, 2024. Mortality, all complications, noninfectious complications, infectious complications, bacteraemia and peritonitis were used as outcomes to compare USPD and USHD.
Results: This meta-analysis incorporated seven studies involving a total of 1,338 patients. Our findings showed no notable distinctions in peritonitis between USPD and USHD. urgent-start PD was linked to a reduced mortality rate “(OR: 0.48, 95% CI: 0.24 to 0.95, p &lt; 0.05), lower all complications (OR: 0.27, 95% CI: 0.20 to 0.37, p &lt; 0.05), lower noninfectious complications(OR: 0.32, 95% CI: 0.23 to 0.45, p &lt; 0.05), lower infectious complications (OR: 0.29, 95% CI: 0.17 to 0.51, p &lt; 0.05), lower bacteraemia (OR: 0.18, 95% CI: 0.07 to 0.42, p &lt; 0.05)” compared to urgent-start HD. 
Conclusions:Our findings indicate that among patients with ESRD, those undergoing urgent-start PD have lower risks during the follow-up period compared to those receiving urgent-start HD. USPD is associated with significantly reduced all-cause mortality, overall complications, infectious complications, non-infectious complications, and bacteremia incidence. The results indicate that USPD could potentially function as an appropriate replacement for USHD. However, further high-quality clinical studies still are necessary to substantiate this conclusion.
DOI: 10.6084/m9.figshare.29389106.v1
title: Supplementary Material for: A Comparison of Clinical Outcomes in Urgent-Start Hemodialysis vs. Urgent-Start Peritoneal Dialysis in ESRD patients: A Systematic Review and Meta-Analysis

description: Background: USPD is related to fewer complications and lower mortality rates compared to USHD in patients who need renal replacement therapy. However, there is a lack of literature specifically addressing its application and results in individuals with ESRD.
Objective: A comprehensive examination and synthesis of existing research were conducted to compare fellow up outcomes of USPD versus USHD in ESRD patients .
Methods: A comprehensive search was conducted in PubMed, Web of Science, and the Cochrane Library, and SpringerLink databases for that compare urgent-start PD to urgent-start HD before November 1th, 2024. Mortality, all complications, noninfectious complications, infectious complications, bacteraemia and peritonitis were used as outcomes to compare USPD and USHD.
Results: This meta-analysis incorporated seven studies involving a total of 1,338 patients. Our findings showed no notable distinctions in peritonitis between USPD and USHD. urgent-start PD was linked to a reduced mortality rate “(OR: 0.48, 95% CI: 0.24 to 0.95, p &lt; 0.05), lower all complications (OR: 0.27, 95% CI: 0.20 to 0.37, p &lt; 0.05), lower noninfectious complications(OR: 0.32, 95% CI: 0.23 to 0.45, p &lt; 0.05), lower infectious complications (OR: 0.29, 95% CI: 0.17 to 0.51, p &lt; 0.05), lower bacteraemia (OR: 0.18, 95% CI: 0.07 to 0.42, p &lt; 0.05)” compared to urgent-start HD. 
Conclusions:Our findings indicate that among patients with ESRD, those undergoing urgent-start PD have lower risks during the follow-up period compared to those receiving urgent-start HD. USPD is associated with significantly reduced all-cause mortality, overall complications, infectious complications, non-infectious complications, and bacteremia incidence. The results indicate that USPD could potentially function as an appropriate replacement for USHD. However, further high-quality clinical studies still are necessary to substantiate this conclusion.
DOI: 10.18150/21qws0
title: ICZMP - 12-lead ECG - part 2

description: 12-lead, resting ECG of the next 22 patients included to the PROVIDE project.Electrocardiograph used: GE Healthcare MAC2000.Legend for file names: ICZMP049-ICZMP070 - subsequent patient codes.The original paper ECGs were first scanned into PDF format, then the PDF files were converted to the JPG format using the offline version of the PDF24 tool, then the patient data was masked using the Microsoft Paint program.
DOI: 10.15468/dl.p5ttth
title: Occurrence Download

description: A dataset containing 25 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Material sample)"
 ]
 }
 },
 "TaxonKey is Cyanolanius comorensis (Shelley, 1894)",
 "Continent is one of (Africa)",
 "Year is greater than or equal to 1900"
 ]
}

 The dataset includes 25 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066697-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29389079
title: Analysis of Biased Allelic Enhancer Activity of Schizophrenia-Linked Common Variants

description: <b>Abstract</b>Schizophrenia is a neuropsychiatric disorder with heritability estimates between 60% and 80%. Although genome-wide association studies have identified many genetic loci linked to the disorder, most of these are noncoding variants whose functional impacts are not well understood. To bridge this gap, we prioritized potential functional variants linked to schizophrenia by utilizing a human brain epigenomic roadmap. We assessed the regulatory activity of these variants using an adapted STARR-seq screening method across four cell lines: Neuro-2a, SH-SY5Y, HEK-293T, and PC-12. Furthermore, we pinpointed candidate target genes through functional characterization and investigated their roles using zebrafish models. Our study identified 351 candidate single nucleotide polymorphisms (SNPs). Among these, 46 SNPs exhibited biased allelic enhancer activity, termed baaSNPs, with notable cell-type specificity. Chromatin interaction profiling and expression quantitative trait loci analyses linked these baaSNPs to 217 candidate target genes, and pathway enrichment analysis indicated that these genes are involved in critical neurological processes such as synaptic transmission and GABAergic signaling. One baaSNP in particular, rs13072690, showed regulatory effects across all examined cell lines and was associated with reduced expression of the <i>PCCB</i> gene in multiple brain regions. Heterozygous <i>pccb</i> knockout zebrafish exhibited abnormal behaviors, including hyperactivity, increased anxiety-like responses, and social deficits. In conclusion, our study demonstrates a valuable strategy for functionally annotating putative risk variants, complementing epigenetic approaches by providing insights into the regulatory potential of noncoding variants associated with schizophrenia. These findings offer promising candidates for further research into the underlying mechanisms of the disorder.
DOI: 10.6084/m9.figshare.29389079.v1
title: Analysis of Biased Allelic Enhancer Activity of Schizophrenia-Linked Common Variants

description: <b>Abstract</b>Schizophrenia is a neuropsychiatric disorder with heritability estimates between 60% and 80%. Although genome-wide association studies have identified many genetic loci linked to the disorder, most of these are noncoding variants whose functional impacts are not well understood. To bridge this gap, we prioritized potential functional variants linked to schizophrenia by utilizing a human brain epigenomic roadmap. We assessed the regulatory activity of these variants using an adapted STARR-seq screening method across four cell lines: Neuro-2a, SH-SY5Y, HEK-293T, and PC-12. Furthermore, we pinpointed candidate target genes through functional characterization and investigated their roles using zebrafish models. Our study identified 351 candidate single nucleotide polymorphisms (SNPs). Among these, 46 SNPs exhibited biased allelic enhancer activity, termed baaSNPs, with notable cell-type specificity. Chromatin interaction profiling and expression quantitative trait loci analyses linked these baaSNPs to 217 candidate target genes, and pathway enrichment analysis indicated that these genes are involved in critical neurological processes such as synaptic transmission and GABAergic signaling. One baaSNP in particular, rs13072690, showed regulatory effects across all examined cell lines and was associated with reduced expression of the <i>PCCB</i> gene in multiple brain regions. Heterozygous <i>pccb</i> knockout zebrafish exhibited abnormal behaviors, including hyperactivity, increased anxiety-like responses, and social deficits. In conclusion, our study demonstrates a valuable strategy for functionally annotating putative risk variants, complementing epigenetic approaches by providing insights into the regulatory potential of noncoding variants associated with schizophrenia. These findings offer promising candidates for further research into the underlying mechanisms of the disorder.
DOI: 10.15468/dl.m4aqg7
title: Occurrence Download

description: A dataset containing 10234 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((16.45539564576345 48.229324216109845, 16.595183357168455 48.221044218983536, 16.60751238850416 48.31513873030807, 16.467466831843126 48.3234365323404, 16.45539564576345 48.229324216109845))"
 ]
}

 The dataset includes 10234 records from 67 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066696-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15726565
title: Supplementary Table S1-S3

description: Supplementary Table S1, High-resolution grain size analysis of cores GEO6 and GEO14 from the Manila Trench; 

Supplementary Table S2, Clay mineral composition of cores GEO6 and GEO14 from the Manila Trench; 

Supplementary Table S3, Detrital zircon U-Pb dating results for cores GEO6 and GEO14 from the Manila Trench
DOI: 10.5281/zenodo.15726566
title: Supplementary Table S1-S3

description: Supplementary Table S1, High-resolution grain size analysis of cores GEO6 and GEO14 from the Manila Trench; 

Supplementary Table S2, Clay mineral composition of cores GEO6 and GEO14 from the Manila Trench; 

Supplementary Table S3, Detrital zircon U-Pb dating results for cores GEO6 and GEO14 from the Manila Trench
DOI: 10.5281/zenodo.15726588
title: Köln Jesuiten-Apotheke (ca. 1924/1947)

description: Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf. gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope): https://kalliope-verbund.info/DE-611-BF-70963 [Funktion: Im Findbuch anzeigen]Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht veröffentlicht werden dürfen).
DOI: 10.5281/zenodo.15726589
title: Köln Jesuiten-Apotheke (ca. 1924/1947)

description: Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf. gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope): https://kalliope-verbund.info/DE-611-BF-70963 [Funktion: Im Findbuch anzeigen]Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht veröffentlicht werden dürfen).