cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/tncdys47mh
title: Code and Data for: Emergent properties in the responses of tropical corals to recurrent climate extremes

description: This URL contains all the data and code from the following paper: https://doi.org/10.1016/j.cub.2021.10.046. Please cite this paper when using any of the data or 
code archived on this site. 

Version 2: Added paper's DOI.
DOI: 10.6084/m9.figshare.23514411.v1
title: Pupil data

description: PEEG_EEG* : individual participant folder. - run*calibration_output.tsv: calibration summary - run*expdata.tsv: raw tobii data (40Hz) - size data collected every 3rd, gaze data at 120Hz - run*markers.tsv: event marker file <br> --- PupCor_output: blink interoplated data (using https://github.com/lindvoo/PupCor). - *_raw_pup_Right.txt: raw pupil size (Right eye) - *_int_pup.txt: linearly interpolated data (Right eye) - *_sm_int_pup.txt: linearly interpolated data with minimal smoothing (Right eye)
DOI: 10.6084/m9.figshare.23931432.v1
title: Supplementary Material for: Staghorn Calculus With Adenomatoid Tumor; A Case Report

description: Testicular adenomatoid tumor is very rare. More understating of the tumor and treatment is required for better outcomes.A 63-year-old man visited a urologist for staghorn calculus. During follow-up, he had recurrent left flank pain and intermittent hematuria. Computed tomography demonstrated left staghorn calculus then further assessment revealed left testicular swelling. Ultrasound showed epidimal mass. Percutaneous nephrolithotomy was deferred and we performed left radical orchiectomy. A pathologic examination revealed testicular adenomatoid tumor. This case highlights the importance of awareness of a very rare benign tumor in a patient with staghorn calculus.
DOI: 10.6084/m9.figshare.7037558.v1
title: Local recurrence rate in a national Danish patient cohort after curative treatment for rectal cancer

description: <b>Aim:</b> Several trials have shown that preoperative (chemo)radiotherapy (CRT) reduces local recurrence rates (LRRs) in rectal cancer (RC). The use of CRT varies greatly between countries. It is unknown whether the restrictive use of CRT in Denmark results in a higher LRR relative to other countries. The aim was to evaluate the LRR in a national Danish consecutive cohort of patients with RC. <b>Methods:</b> All data from patients with RC in Denmark in 2009–2010 who were operated on with curative intent were retrieved from the Danish Colorectal Cancer Group database. Patients with metastases at the time of diagnosis, patients with synchronous colon cancer, and patients, in whom only local surgical procedures were performed, were excluded. In total, 1633 patients met the inclusion criteria. Clinical follow-up was at least five years with a cut-off date of 31 December 2015. <b>Results:</b> Clinical follow-up was 5.4 years (median) with an interquartile range of 4.5–6.1 years. Of all included patients, 479 (29%) were treated with preoperative long-course CRT. Local recurrence was found in 68 patients, resulting in an LRR of 4.2%, and 182 (11%) patients developed distant metastases. Five-year overall survival was 74% (95% CI: 71.64–75.91). <b>Conclusions:</b> Five-year follow-up of curatively treated patients with RC in Denmark revealed a low LRR. This figure is identical to those reported in other Nordic countries, despite Denmark’s considerably stricter guidelines for CRT. The obtained results justify the currently adopted restrictive use of preoperative CRT in Denmark.
DOI: 10.6084/m9.figshare.19251515.v1
title: Grapevine Leaf Elemental Composition

description: This data set contains measurements of leaf elemental composition for over 7000 grafted grapevine leaves measured across different leaf position, rootstock genotypes, phenological stages, and years. Thie data set contains each of the following: 1) Raw output from the DDPSC Ionomics Pipeline for each of the 9 timepoints. 2) Means and sds used for back-transformation into concentration space following imputation. 3) The imputed z-scores. 4) The full imputed data set in concentration space. 5) The full metadata set. 6) An archive/version of record for all Jupyter Notebooks used in this analysis.
DOI: 10.6084/m9.figshare.21879048.v5
title: Stronger compensatory thermal adaptation of soil microbial respiration with higher substrate availability

description: There are two items: the first one contains the R code (QuetalCODE.txt) whereas the second one has the data (QuetalDATA.xslx). In the latter item there are four spreadsheets. The spreadsheet "This study" contains the raw data from a Chinese forest transect. The spreadsheet "Bradford et al. (2019)" contains the raw data from American forest and herb transect. The spreadsheet "Dacal et al. (2019)" contains the raw data from a global dryland transect. The spreadsheet "METADATA" contains the associated metadata, where a description of all the variables and units can be found. All the methodological details can be found in the article.
DOI: 10.6084/m9.figshare.22724663.v1
title: Aburra Valley notified dengue cases and wMel Wolbachia prevalence by comuna and month

description: This dataset holds monthly dengue case notifications data and Wolbachia monitoring for each reporting area (comuna) in the three Colombian cities of Bello, Medellin and Itagui, where wMel Wolbachia deployments were conducted between 2015 and 2021. It underlies the interrupted time series analysis and results reported in the paper by Velez et al "Reduced dengue incidence following city-wide wMel Wolbachia mosquito releases throughout three Colombian cities: interrupted time series analysis and a prospective case-control study" published in PLoS Neglected Tropical Diseases in 2023.
DOI: 10.17632/tf95rbjkxw
title: Data for: Crack kinking in a variational phase-field model of brittle fracture with strongly anisotropic surface energy

description: FEniCS based finite element solver for the minimization of the energy functional of a phase-field model for fracture of a material with strongly anisotropic surface energy
DOI: 10.17632/6f8w2nx4zz
title: Data for: Parallel multi-agent real-coded genetic algorithm for large-scale black-box single-objective optimisation

description: Content Dataset on Yerevan (XLS): 1. List of activities of enerprises of Yerevan, Aremenia 2. List of main enterprises of Yerevan, Armenia 3. List of main kindergartens of Yerevan, Armenia 4. List of node coordinates of main roads of Yerevan, Armenia 5. Data on initial radiuses of object-emissions 6. Data on harmful emissions produced by enterprises of Yerevan, Armenia 7. Data on absoprion characteristics of trees planted in Yerevan, Armenia 8. Content AnyLogic model (ZIP): Yerevan_kindergartents.alp - the main file of the simulation that can be opened in AnyLogic tool Content EcModel2 (ZIP): Model2.bak - the database file in the MS SQL Server format that should be installed before running AnyLogic model. Steps to reproduce: To open the Anylogic model you need load and install the AnyLogic simulation tools shared in https://www.anylogic.com/. The code of the model has the '*.alp' extension. In addition, the installation of the database (Ecmodel2.bak) is needed. After this, you need check and correct the connection string in the AnyLogic model (database properties) including Host, Database name, Login and Password. Only after these steps, you can run and use the AnyLogic model. Your computer should have supporting Java virtual machine (JVM) and both AnyLogic and MS SQL Server should be installed. Note that model is intended for the Yerevan city only and its used appropriate data.
DOI: 10.17632/sh683s8mwf
title: Prey stoichiometry and phytoplankton and zooplankton composition influence the production of marine crustacean zooplankton

description: This online dataset includes the in situ copepod growth and production rates, primary production, nutrient concentrations and plankton community assemblage we measured in the East China Sea and South China Sea. File "TableA1_CPdatabase.xls" presents the secondary and primary production, stoichiometry and other key environmental data. File "AbunRatioCopepod.xls" presents the abundance (ind/m3) of main copepod groups. File "BiovRatioPhyto.xls" present the biovolume (um3/L) of main phytoplankton groups. The R file "MTE_AnalysisPublishPiO.R" includes our codes for data analyses.
DOI: 10.6084/m9.figshare.1119146.v6
title: Coronary heart disease clinical practice guideline Colombia: an untold story

description: More details will be added soon. For more information visit my Twitter accouint or contact me by email.
DOI: 10.6084/m9.figshare.29092535.v1
title: 数据附件.rar

description: 由于人们对新鲜农产品 （FAP） 的新鲜度和质量的担忧日益增加，新鲜农产品供应链 （FAPSC） 的优化变得越来越重要。部署油电混合车队以一起安排收获和分配的供应模式是一种很有前途的方法。这些模式不仅通过缩短 FAPSC 来帮助提供高新鲜度和高质量的 FAP，而且还减少了 FAPSC 物流活动的碳排放。这种供应模式需要做出具有多个目标的决策，处理这些决策之间的关系以进行整体优化，并开发高效的解决方案方法以提高供应链的运营效率。本研究提出了一个多目标调度问题，该问题使用混合油电车队整合了 FAP 的收获和分配。首先，基于时空状态框架制定混合整数模型，以最大限度地降低运营成本并最大限度地提高订单满意度。其次，开发了一种由 Q-learning （QHA） 改进的启发式算法，并根据问题的特点设计了四种不同的进化方法。特别是，考虑到 FAP 订单数量的随机性和季节性，为随机订单设计了一种改进的定期重新优化方法。最后，将 QHA 与基于显性的方法、基于分解的方法和 QHA 的变体进行比较，以验证其优越性。还将改进的周期性再优化方法与即时再优化方法和周期性重新优化方法进行了比较，以验证其有效性。
DOI: 10.6084/m9.figshare.29148719.v1
title: Mejia et al. - Annual precipitation and bat species richness affect the structure of bat-bat fly interaction networks.zip

description: Matrices containing information on bats and their ectoparasites were used to test the influence of climatic seasonality on the structure of bat-bat fly interaction networks. This document also contains a file containing all the information from which the interaction data was extracted.
DOI: 10.17632/cg356nh4vm
title: Impact of environmental, social, and corporate governance responsibility factors on public companies' cost of capital in emerging markets

description: Data required to perform econometrical analysis using R tools. Dataset is created to test the influence of environmental, social, and corporate governance responsibility factors (ESG) on public companies' cost of capital in emerging markets (in EMEA and Latin America countries). Data is presented in sheets: MSCI EM sheet refers to total sample, MSCI EM NONFINAN - sample excluding financial firms, CRP is necessary to calculate cost of equity on COFEQUITY CALC sheet, EMEA/LATAM_List /Hard/Reg are intermediate sheets for obtaining final REG_ALL. On REG_ALL each variable is grouped by color (dependent/independent variables, variables of interest, etc.).
DOI: 10.17632/j6sbm5jhfc
title: koptekcnh İlaç Sipariş 0552 369 35 87 whatsapp Tan Bilgi Alınız koptekcnh İlaç Sipariş Ver

description: koptekcnh İlaç Sipariş 0552 369 35 87 whatsapp Tan Bilgi Alınız koptekcnh İlaç Sipariş Ver  koptekcnh İlaç Sipariş 0552 369 35 87 whatsapp Tan Bilgi Alınız koptekcnh İlaç Sipariş Ver   koptekcnh İlaç Sipariş 0552 369 35 87 whatsapp Tan Bilgi Alınız koptekcnh İlaç Sipariş Ver   koptekcnh İlaç Sipariş 0552 369 35 87 whatsapp Tan Bilgi Alınız koptekcnh İlaç Sipariş Ver   koptekcnh İlaç Sipariş 0552 369 35 87 whatsapp Tan Bilgi Alınız koptekcnh İlaç Sipariş Ver
DOI: 10.25574/25381
title: Chandra X-ray Observatory ObsId 25381

description: Identification of Two X-ray Jets in High-Redshift Quasars
DOI: 10.6084/m9.figshare.29940003.v1
title: In-vitro metabolite identification for MEDI7219, an oral GLP-1 analog, using LC-MS/MS with CID and EAD approaches

description: Oral peptide therapeutics typically have short half-lives due to rapid degradation by digestive enzymes. Systematic peptide engineering and formulation optimization led to the development of a clinical candidate MEDI7219, an orally bioavailable glucagon-like peptide 1 (GLP-1) peptide, with greater stability than wild-type GLP-1 or semaglutide:~60% of MEDI7219 remained intact after 2 h in vitro incubation with simulated intestinal fluid. This study further investigates proteolytic stability by elucidating biotransformation products of MEDI7219 using liquid chromatography-mass spectrometry (LC-MS) methods. Peptide metabolism was assessed using in vitro pancreatin assay followed by analysis utilizing liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) using collision-induced dissociation (CID) and electron-activated dissociation (EAD) approaches. We have confidently identified 13 metabolites. Time course profiles of parent and metabolite peaks are consistent with sequential enzymatic cleavage pattern. The 13 metabolites mapped to 8 cleavage sites. Most of these cleavage sites can be explained by the specificity of digestive enzymes, <i>e.g.</i> trypsin, pepsin, and elastase. However, α-methyl-L-phenylalanine appeared to be well protected from chymotrypsin and pepsin digestion since no cleavage peptides ending with α-methyl-L-phenylalanine were observed. These study results provide further structural details explaining previously published stability data and provide new insights into potential GLP1 proteolytic liabilities for future engineering <b>What is this article about?</b> Oral peptide drugs are challenging to develop because oral drugs can be rapidly degraded by digestive enzymes in the gastrointestinal tract. To overcome this challenge, a GLP1 analog, MEDI7219, was developed as a clinical candidate. MEDI7219 is more stable than other GLP1 agonists such as semaglutide. A previous study showed that 60% of MEDI7219 remained stable after 2 h incubation with digestive enzymes. This study builds on the earlier findings and further characterizes the degradation products that occur after incubation of the peptide analog with digestive enzymes using advanced analytical instrumentation. <b>What were the results?</b> Our results identified a list of degradation products and time course patterns of this degradation. These results also revealed vulnerable spots in peptide sequence as well as protected regions. <b>What do the results of the study mean?</b> This information can help guide future oral peptide development to engineer more stable oral peptide products for chronic disease.
DOI: 10.6084/m9.figshare.29610738.v1
title: LC-MS/MS quantification of nusinersen in rat cerebrospinal fluid and preclinical pharmacokinetics study application

description: Background: An oligonucleotide drug named nusinersen sodium is used to treat Spinal Muscular Atrophy (SMA), requires accurate detection for therapeutic research. There are no published reports on liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for detecting nusinersen in rat cerebrospinal fluid (CSF). An LC-MS/MS method has been created and verified to detect nusinersen in Sprague-Dawley (SD) rat CSF. The method employed solid-phase extraction for post-extraction analysis and used dT20 as an internal standard. Negative ion multiple reaction monitoring (MRM) mode scanning and the electrospray ionization (ESI) source were used. The method was validated over a concentration range of 5–2000 ng/mL with a Lower Limit of Quantification (LLOQ) of for nusinersen at 5 ng/mL. The method achieves extremely high accuracy and precision, good linearity, high extraction recovery, and provides a useful approach for evaluating the pharmacokinetics of nusinersen in rats.
DOI: 10.6084/m9.figshare.29940003
title: In-vitro metabolite identification for MEDI7219, an oral GLP-1 analog, using LC-MS/MS with CID and EAD approaches

description: Oral peptide therapeutics typically have short half-lives due to rapid degradation by digestive enzymes. Systematic peptide engineering and formulation optimization led to the development of a clinical candidate MEDI7219, an orally bioavailable glucagon-like peptide 1 (GLP-1) peptide, with greater stability than wild-type GLP-1 or semaglutide:~60% of MEDI7219 remained intact after 2 h in vitro incubation with simulated intestinal fluid. This study further investigates proteolytic stability by elucidating biotransformation products of MEDI7219 using liquid chromatography-mass spectrometry (LC-MS) methods. Peptide metabolism was assessed using in vitro pancreatin assay followed by analysis utilizing liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) using collision-induced dissociation (CID) and electron-activated dissociation (EAD) approaches. We have confidently identified 13 metabolites. Time course profiles of parent and metabolite peaks are consistent with sequential enzymatic cleavage pattern. The 13 metabolites mapped to 8 cleavage sites. Most of these cleavage sites can be explained by the specificity of digestive enzymes, <i>e.g.</i> trypsin, pepsin, and elastase. However, α-methyl-L-phenylalanine appeared to be well protected from chymotrypsin and pepsin digestion since no cleavage peptides ending with α-methyl-L-phenylalanine were observed. These study results provide further structural details explaining previously published stability data and provide new insights into potential GLP1 proteolytic liabilities for future engineering <b>What is this article about?</b> Oral peptide drugs are challenging to develop because oral drugs can be rapidly degraded by digestive enzymes in the gastrointestinal tract. To overcome this challenge, a GLP1 analog, MEDI7219, was developed as a clinical candidate. MEDI7219 is more stable than other GLP1 agonists such as semaglutide. A previous study showed that 60% of MEDI7219 remained stable after 2 h incubation with digestive enzymes. This study builds on the earlier findings and further characterizes the degradation products that occur after incubation of the peptide analog with digestive enzymes using advanced analytical instrumentation. <b>What were the results?</b> Our results identified a list of degradation products and time course patterns of this degradation. These results also revealed vulnerable spots in peptide sequence as well as protected regions. <b>What do the results of the study mean?</b> This information can help guide future oral peptide development to engineer more stable oral peptide products for chronic disease.
DOI: 10.15468/dl.78g3na
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Oenothera glazioviana",
 "Country is India",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025748-250811113504898/datasets/export for details.
DOI: 10.6084/m9.figshare.29610738
title: LC-MS/MS quantification of nusinersen in rat cerebrospinal fluid and preclinical pharmacokinetics study application

description: Background: An oligonucleotide drug named nusinersen sodium is used to treat Spinal Muscular Atrophy (SMA), requires accurate detection for therapeutic research. There are no published reports on liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for detecting nusinersen in rat cerebrospinal fluid (CSF). An LC-MS/MS method has been created and verified to detect nusinersen in Sprague-Dawley (SD) rat CSF. The method employed solid-phase extraction for post-extraction analysis and used dT20 as an internal standard. Negative ion multiple reaction monitoring (MRM) mode scanning and the electrospray ionization (ESI) source were used. The method was validated over a concentration range of 5–2000 ng/mL with a Lower Limit of Quantification (LLOQ) of for nusinersen at 5 ng/mL. The method achieves extremely high accuracy and precision, good linearity, high extraction recovery, and provides a useful approach for evaluating the pharmacokinetics of nusinersen in rats.
DOI: 10.6084/m9.figshare.29950406.v1
title: cell cycle.zipcell cycle 原始数据发布

description: After the glioma cells were digested with trypsin, 1×10<sup>6</sup>cells were taken in a 15mL centrifuge tube with a sharp bottom, washed twice with precooled PBS, and then cooled overnight in 70% ethanol. According to the instructions of cell cycle detection kit (Beyotime, Shanghai, China), propidium iodide staining was carried out, and flow cytometry (BD Accuri C6 Plus) was used for analysis. Results from cell cycle analysis demonstrate that either knockdown or overexpression of ASIC2 significantly alters the cell cycle progression and proliferation rate of glioma cells. Specifically, distinct changes were observed in the distribution of cells across different cell cycle phases, accompanied by corresponding increases or decreases in the rate of cell proliferation. These findings suggest that ASIC2 likely plays an important role in regulating the cell cycle in glioma cells.
DOI: 10.6084/m9.figshare.29218619.v2
title: Medical Doctors’ Perceptions of Generative AI Across the United States: A Sentiment Analysis of X

description: Physicians’ AI sentiment
DOI: 10.15468/dl.ba5ekg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Hippocamelus bisulcus (Molina, 1782))",
 "Country is one of (Algeria, Angola, Benin, Botswana, British Indian Ocean Territory, Burkina Faso, Burundi, Cabo Verde, Cameroon, Central African Republic, Chad, Comoros, Congo, Congo, Democratic Republic of the, Côte d’Ivoire, Djibouti, Egypt, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, French Southern Territories, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Lesotho, Liberia, Libya, Madagascar, Malawi, Mali, Mauritania, Mauritius, Mayotte, Morocco, Mozambique, Namibia, Niger, Nigeria, Réunion, Rwanda, Saint Helena, Ascension and Tristan da Cunha, Sao Tome and Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Africa, South Sudan, Sudan, Tanzania, United Republic of, Togo, Tunisia, Uganda, Western Sahara, Zambia, Zimbabwe)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016423-250525065834625/datasets/export for details.
DOI: 10.15468/dl.xwwmj6
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Hippocamelus bisulcus (Molina, 1782))",
 "Country is one of (American Samoa, Australia, Christmas Island, Cocos (Keeling) Islands, Cook Islands, Fiji, French Polynesia, Guam, Heard Island and McDonald Islands, Kiribati, Marshall Islands, Micronesia (Federated States of), Nauru, New Caledonia, New Zealand, Niue, Norfolk Island, Northern Mariana Islands, Palau, Papua New Guinea, Pitcairn, Samoa, Solomon Islands, Tokelau, Tonga, Tuvalu, United States Minor Outlying Islands, Vanuatu, Wallis and Futuna)"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016422-250525065834625/datasets/export for details.
DOI: 10.15468/dl.g72ns5
title: Occurrence Download

description: A dataset containing 425248 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Country is one of (Canada, Mexico, United States of America)",
 "EventDate is greater than or equal to 2025-12-06",
 "EventDate is less than or equal to 2026-01-05",
 {
 "not" : {
 "Issue" : [
 "is one of (Basis of record invalid, Coordinate reprojection failed, Coordinate reprojection suspicious, Coordinate precision invalid, Coordinate uncertainty meters invalid, Country mismatch, Country invalid, Geodetic datum invalid, Presumed swapped coordinate, Presumed negated longitude, Presumed negated latitude, Country coordinate mismatch)"
 ]
 }
 },
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 425248 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004131-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.