cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25383/city.9221843.v1
title: Data on the construction and validation of the Challenge Originating from Recent Gameplay Interaction Scale (CORGIS) - A psychometric tool for measuring perceived challenge in video games

description: This dataset consists of a single<b> Excel .xlsx </b>spreadsheet with four tabs. The data include a psychometric instrument for measuring perceived challenge in video games (named the <b>Challenge Originating from Recent Gameplay Interaction Scale</b>, or <b>CORGIS</b>), along with complementary data on how the CORGIS was derived and validated. <br>Names and brief explanations of the four tabs are as follows:- <b>CORGIS - Final</b>: The final CORGIS questionnaire of 30 questions, arranged into 4 sub-scales of Cognitive Challenge, Emotional Challenge, Performative Challenge, and Decision-Making Challenge. The questionnaire is intended for use as a Likert scale, in which answers range from 1 = 'strongly disagree' to 7 = 'strongly agree', with 4 being the neutral 'neither agree nor disagree'.- <b>Initial Items Pool and PCA</b>: An initial pool of 60 questions constructed via literature review and interviews with players, and refined to remove items not relevant to 'challenge'. Loadings of single-factor and four-factor Exploratory Factor Analysis based on the Likert responses are presented alongside the questions.- <b>Online survey I - Games</b>: A list of video games played by participants in the first of two online surveys. Data includes each game's genre and the frequencies of games per genre.- <b>Online survey II - Games</b>: A list of video games played by participants in the second of two online surveys. Data includes each game's genre and the frequencies of games per genre.<br><br>The related study gives an in-depth description of the creation of the CORGIS psychometric tool for measuring perceived challenge in digital games. The CORGIS is a systematic, extensive and reliable instrument to evaluate the level of player's perceived challenge in digital games, with the wider goal of providing a robust measure that can be used by both game developers and researchers to quantify players' challenge experiences.
DOI: 10.6084/m9.figshare.9221954.v1
title: Exploring patient and public involvement in motor neuron disease research

description: <i>Objectives:</i> Patient and public involvement (PPI) is a relatively new practice whereby researchers involve patients and the public in the conduct of their research. The Sheffield Motor Neurone Disorders Research Advisory Group (SMNDRAG) is one of the first groups to specialise in motor neuron disease (MND). Its members include people living with MND, carers, relatives, volunteers, clinicians, and scientists. Our aim was to explore the experiences of those who participate in, organise and work with the SMNDRAG. <i>Methods:</i> We conducted 13 semi-structured interviews: 10 with members of the SMNDRAG and three with researchers who have worked with the group. We used thematic analysis to identify ways in which the group influenced research and the barriers and enablers to PPI. <i>Results:</i> A number of motivations for participating in the SMNDRAG were reported but the majority were altruistic. The SMNDRAG offered individuals psychosocial and intellectual benefits. The SMNDRAG has overcome a number of practical and psychological barriers to developing a successful and effective collaborative partnership resulting in a positive impact on research and researchers at each stage of the research process. For example, the group identified research priorities which ensured that research was patient-focused. However, several barriers remain, including the lack of diversity within the group and the perception that PPI participation requires a “certain type of person.” <i>Conclusions:</i> PPI can make a valuable contribution to all aspects of research and can have a positive impact on those involved. We recommend ways in which PPI can and should be incorporated into research.
DOI: 10.6084/m9.figshare.9221084
title: Urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells.

description: Digested peptides (n = 27) were dissolved in 0.1% formic acid to a concentration of 0.5 µg/µL. For analysis, 1 µg<i> </i>of<i> </i>peptide from each sample was loaded into a trap column (75 µm × 2 cm, 3 µm, C18, 100 Å) at a flow rate of 0.25 µL/min and then separated with a reversed-phase analytical column (75 µm × 250 mm, 2 µm, C18, 100 Å). Peptides were eluted with a gradient extending from 4%–35% buffer B (0.1% formic acid in 80% acetonitrile) for 90 min and then analyzed with an Orbitrap Fusion Lumos Tribrid Mass Spectrometer (Thermo Fisher Scientific, Waltham, MA). The MS data were acquired using the following parameters: i) data-dependent MS/MS scans per full scan were auquired at the top-speed mode; ii) MS scans had a resolution of 120,000, and MS/MS scans had a resolution of 30,000 in Orbitrap; iii) HCD collision energy was set to 30%; iv) dynamic exclusion was set to 30 s; v) the charge-state screening was set to +2 to +7; and vi) the maximum injection time was 45 ms. Each peptide sample was analyzed twice.Raw data files (n=54) were searched using Mascot software (version 2.5.1, Matrix Science, London, UK) against the Swiss-Prot rat database (released in February 2017, containing 7,992 sequences). The parent ion tolerance was set to 10 ppm, and the fragment ion mass tolerance was set to 0.02 Da. The carbamidomethylation of cysteine was set as a fixed modification, and the oxidation of methionine was considered a variable modification. Two missed trypsin cleavage sites were allowed, and the specificity of trypsin digestion was set for cleavage after lysine or arginine. Dat files (n=54) were exported from Mascot software and then processed using Scaffold software (version 4.7.5, Proteome Software Inc., Portland, OR). The parameters were set as follows: both peptide and protein identifications were accepted at a false discovery rate (FDR) of less than 1.0% and proteins were identified with at least two unique peptides. Different samples were compared after normalization with the total spectra. In this dataset,we present the mass spectrometry DAT files. Numbers 1-9 represent Rat 1-D0 to Rat 9- D0, numbers 10-18 represent Rat 1-D13 to Rat 9- D13 and numbers 19-27 represent Rat 1-D21 to Rat 9-D21.
DOI: 10.6084/m9.figshare.9221084.v1
title: Urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells.

description: Digested peptides (n = 27) were dissolved in 0.1% formic acid to a concentration of 0.5 µg/µL. For analysis, 1 µg<i> </i>of<i> </i>peptide from each sample was loaded into a trap column (75 µm × 2 cm, 3 µm, C18, 100 Å) at a flow rate of 0.25 µL/min and then separated with a reversed-phase analytical column (75 µm × 250 mm, 2 µm, C18, 100 Å). Peptides were eluted with a gradient extending from 4%–35% buffer B (0.1% formic acid in 80% acetonitrile) for 90 min and then analyzed with an Orbitrap Fusion Lumos Tribrid Mass Spectrometer (Thermo Fisher Scientific, Waltham, MA). The MS data were acquired using the following parameters: i) data-dependent MS/MS scans per full scan were auquired at the top-speed mode; ii) MS scans had a resolution of 120,000, and MS/MS scans had a resolution of 30,000 in Orbitrap; iii) HCD collision energy was set to 30%; iv) dynamic exclusion was set to 30 s; v) the charge-state screening was set to +2 to +7; and vi) the maximum injection time was 45 ms. Each peptide sample was analyzed twice.Raw data files (n=54) were searched using Mascot software (version 2.5.1, Matrix Science, London, UK) against the Swiss-Prot rat database (released in February 2017, containing 7,992 sequences). The parent ion tolerance was set to 10 ppm, and the fragment ion mass tolerance was set to 0.02 Da. The carbamidomethylation of cysteine was set as a fixed modification, and the oxidation of methionine was considered a variable modification. Two missed trypsin cleavage sites were allowed, and the specificity of trypsin digestion was set for cleavage after lysine or arginine. Dat files (n=54) were exported from Mascot software and then processed using Scaffold software (version 4.7.5, Proteome Software Inc., Portland, OR). The parameters were set as follows: both peptide and protein identifications were accepted at a false discovery rate (FDR) of less than 1.0% and proteins were identified with at least two unique peptides. Different samples were compared after normalization with the total spectra. In this dataset,we present the mass spectrometry DAT files. Numbers 1-9 represent Rat 1-D0 to Rat 9- D0, numbers 10-18 represent Rat 1-D13 to Rat 9- D13 and numbers 19-27 represent Rat 1-D21 to Rat 9-D21.
DOI: 10.6084/m9.figshare.9220010
title: Spatial determinants of inventive capacity in Brazil: the role of inventor networks

description: This paper investigates the role of inventor networks in regional inventive capacity in Brazil for 558 regions in the period 2000–11. Based on the knowledge-production function (KPF), it focuses on four network measurements: intra- and interregional collaborative inventor links, density of the network, and international collaboration among Brazilian and foreign inventors. The main results show that intra-regional inventive collaborations exert a positive impact, while denser networks negatively influence regional inventive productivity. Interregional collaborative links have a ‘U’-shape relationship with inventive productivity only for South and Southeast. Inventions in the North, Northeast and Centre–West rely on international collaborative links.
DOI: 10.6084/m9.figshare.9220010.v2
title: Spatial determinants of inventive capacity in Brazil: the role of inventor networks

description: This paper investigates the role of inventor networks in regional inventive capacity in Brazil for 558 regions in the period 2000–11. Based on the knowledge-production function (KPF), it focuses on four network measurements: intra- and interregional collaborative inventor links, density of the network, and international collaboration among Brazilian and foreign inventors. The main results show that intra-regional inventive collaborations exert a positive impact, while denser networks negatively influence regional inventive productivity. Interregional collaborative links have a ‘U’-shape relationship with inventive productivity only for South and Southeast. Inventions in the North, Northeast and Centre–West rely on international collaborative links.
DOI: 10.6084/m9.figshare.9213314
title: Clinical characteristics and survival in non-small cell lung cancer patients by smoking history: a population-based cohort study

description: <b>Introduction:</b> Approximately, 10–15% of lung cancer patients have never smoked. Previous epidemiological studies on non-tobacco associated lung cancer have been hampered by selected data from a small number of hospitals or limited numbers of patients. By use of data from large population-based registers with national coverage, this study aims to compare characteristics and survival of patients with non-small cell lung cancer (NSCLC) with different smoking histories. <b>Methods:</b> Swedish national population-based registers were used to retrieve data on patients diagnosed with primary NSCLC between 2002 and 2016. The Kaplan–Meier method and Cox proportional hazard models were used to estimate overall survival and lung cancer-specific survival by smoking history. <b>Results:</b> In total, 41,262 patients with NSCLC were included. Of those, 4624 (11%) had never smoked. Never-smokers were more often women and older compared to ever smokers (current and former). Adenocarcinoma was proportionally more common in never-smokers (77%) compared to current (52%) and former smokers (57%). Stage IV disease was more common in never-smokers (57%) than in current (48%) and former smokers (48%). Epidermal growth factor receptor mutation was observed more in never-smokers (37%) compared to current (5%) and former smokers (9%). Both lung cancer-specific and overall survival were higher for never-smokers compared to current smokers. <b>Conclusions:</b> The observed differences in characteristics between never-smokers and smokers, and the higher survival in never-smokers compared to smokers from this large population-based study provide further evidence that lung cancer in never-smokers is clinically different to tobacco-associated lung cancer. The findings from this study emphasise the need for an improved understanding of genetics, pathogenesis, mechanisms and progression of non-tobacco associated lung cancer that may help prevent lung cancer or identify individually targeted treatments.
DOI: 10.6084/m9.figshare.9220010.v1
title: Spatial determinants of inventive capacity in Brazil: the role of inventor networks

description: This paper investigates the role of inventor networks in regional inventive capacity in Brazil for 558 regions in the period 2000–11. Based on the knowledge-production function (KPF), it focuses on four network measurements: intra- and interregional collaborative inventor links, density of the network, and international collaboration among Brazilian and foreign inventors. The main results show that intra-regional inventive collaborations exert a positive impact, while denser networks negatively influence regional inventive productivity. Interregional collaborative links have a ‘U’-shape relationship with inventive productivity only for South and Southeast. Inventions in the North, Northeast and Centre–West rely on international collaborative links.
DOI: 10.6084/m9.figshare.9213314.v1
title: Clinical characteristics and survival in non-small cell lung cancer patients by smoking history: a population-based cohort study

description: <b>Introduction:</b> Approximately, 10–15% of lung cancer patients have never smoked. Previous epidemiological studies on non-tobacco associated lung cancer have been hampered by selected data from a small number of hospitals or limited numbers of patients. By use of data from large population-based registers with national coverage, this study aims to compare characteristics and survival of patients with non-small cell lung cancer (NSCLC) with different smoking histories. <b>Methods:</b> Swedish national population-based registers were used to retrieve data on patients diagnosed with primary NSCLC between 2002 and 2016. The Kaplan–Meier method and Cox proportional hazard models were used to estimate overall survival and lung cancer-specific survival by smoking history. <b>Results:</b> In total, 41,262 patients with NSCLC were included. Of those, 4624 (11%) had never smoked. Never-smokers were more often women and older compared to ever smokers (current and former). Adenocarcinoma was proportionally more common in never-smokers (77%) compared to current (52%) and former smokers (57%). Stage IV disease was more common in never-smokers (57%) than in current (48%) and former smokers (48%). Epidermal growth factor receptor mutation was observed more in never-smokers (37%) compared to current (5%) and former smokers (9%). Both lung cancer-specific and overall survival were higher for never-smokers compared to current smokers. <b>Conclusions:</b> The observed differences in characteristics between never-smokers and smokers, and the higher survival in never-smokers compared to smokers from this large population-based study provide further evidence that lung cancer in never-smokers is clinically different to tobacco-associated lung cancer. The findings from this study emphasise the need for an improved understanding of genetics, pathogenesis, mechanisms and progression of non-tobacco associated lung cancer that may help prevent lung cancer or identify individually targeted treatments.
DOI: 10.6084/m9.figshare.9211682
title: Inter-professional collaboration reduces the burden of caring for patients with mental illnesses in primary healthcare. A realist evaluation study

description: <b>Background:</b> The implementation of primary care for mental health is often insufficient, which leaves its mark on staff. A team-based approach of mental healthcare prevents poor staff morale. A community health centre (CHC), therefore, set up a project promoting interprofessional collaboration with a mental health team (MHT). <b>Objectives:</b> This study aimed to understand how an MHT would influence staff morale in a primary care setting, aiming to formulate some recommendations for future projects. <b>Methods:</b> In 2017, interviews and a focus group discussion were conducted among the staff of a CHC. Using a qualitative approach, we aimed to unravel contextual factors and mechanisms that determine the effect of an MHT on staff morale. <b>Results:</b> The project relieved the burden of the patient encounters and staff members felt more valuable to patients. Underlying mechanisms were recognition, altered attitudes towards patients and role clarity. Facilitating factors were intercultural care mediators and a positive team atmosphere, whereas inhibiting factors were inefficient time management and communicative issues. <b>Conclusion:</b> Our study elucidated mechanisms and the contextual factors by which an MHT in general practice improves staff morale. KEY MESSAGESAn MHT improves staff morale in a CHC, through nurturing recognition, through altering staff members' attitudes and through ensuring role clarity.Pitfalls are inefficient time management and poor communication.Policymakers should stimulate interprofessional collaboration in primary mental health. KEY MESSAGES An MHT improves staff morale in a CHC, through nurturing recognition, through altering staff members' attitudes and through ensuring role clarity. Pitfalls are inefficient time management and poor communication. Policymakers should stimulate interprofessional collaboration in primary mental health.
DOI: 10.6084/m9.figshare.9211643
title: Tetrapod uCT scan data: pathologies

description: from this paper:Herbst, E.C., Doube, M., Smithson, T.R., Clack, J.A., Hutchinson, J.R. 2019. Bony lesions in early tetrapods and the evolution of mineralized tissue repair. Paleobiology, in press. <br>see table in supp info for more specimen metadata: doi:10.5061/dryad.30kp1qg<br>Crassigyrinus and Eoherpeton early tetrapod postcranial elements with pathologies (8 scan datasets as .zip archives):<br>1. Crassigyrinus NHMUKVPR10000_healed_rib_fragment<br>2. Crassigyrinus NMSG1984.15.1ABC L fibula, L ilium, L femur<br>3. Crassigyrinus NMSG1984.15.2 metatarsal pathology<br>4. Crassigyrinus NMSG1984.15.3_L ischium R tibia R fibula, presacral rib<br>5. Crassigyrinus NHMUK R1000_rib fragment_high resolution: sampled_every_5th slice6. Crassigyrinus NMSG1984.15.3 tibia_proximal_only_higher_resolution- every 2nd slice7. Eoherpeton NMS G 1993.56.25 R fibula distal section high resolution<br>8. Eoherpeton R_fibula &b Neural Arches_1993.56.25, 33A &33B_8bit<br>
DOI: 10.6084/m9.figshare.9211640
title: MosqGua.Rhtml

description: R script
DOI: 10.6084/m9.figshare.9211682.v1
title: Inter-professional collaboration reduces the burden of caring for patients with mental illnesses in primary healthcare. A realist evaluation study

description: <b>Background:</b> The implementation of primary care for mental health is often insufficient, which leaves its mark on staff. A team-based approach of mental healthcare prevents poor staff morale. A community health centre (CHC), therefore, set up a project promoting interprofessional collaboration with a mental health team (MHT). <b>Objectives:</b> This study aimed to understand how an MHT would influence staff morale in a primary care setting, aiming to formulate some recommendations for future projects. <b>Methods:</b> In 2017, interviews and a focus group discussion were conducted among the staff of a CHC. Using a qualitative approach, we aimed to unravel contextual factors and mechanisms that determine the effect of an MHT on staff morale. <b>Results:</b> The project relieved the burden of the patient encounters and staff members felt more valuable to patients. Underlying mechanisms were recognition, altered attitudes towards patients and role clarity. Facilitating factors were intercultural care mediators and a positive team atmosphere, whereas inhibiting factors were inefficient time management and communicative issues. <b>Conclusion:</b> Our study elucidated mechanisms and the contextual factors by which an MHT in general practice improves staff morale. KEY MESSAGESAn MHT improves staff morale in a CHC, through nurturing recognition, through altering staff members' attitudes and through ensuring role clarity.Pitfalls are inefficient time management and poor communication.Policymakers should stimulate interprofessional collaboration in primary mental health. KEY MESSAGES An MHT improves staff morale in a CHC, through nurturing recognition, through altering staff members' attitudes and through ensuring role clarity. Pitfalls are inefficient time management and poor communication. Policymakers should stimulate interprofessional collaboration in primary mental health.
DOI: 10.6084/m9.figshare.9211607
title: mosqGua2_Metadata.csv

description: meta data
DOI: 10.6084/m9.figshare.9211640.v1
title: MosqGua.Rhtml

description: R script
DOI: 10.6084/m9.figshare.9211607.v1
title: mosqGua2_Metadata.csv

description: meta data
DOI: 10.6084/m9.figshare.9211643.v1
title: Tetrapod uCT scan data: pathologies

description: from this paper:Herbst, E.C., Doube, M., Smithson, T.R., Clack, J.A., Hutchinson, J.R. 2019. Bony lesions in early tetrapods and the evolution of mineralized tissue repair. Paleobiology, in press. <br>Crassigyrinus and Eoherpeton early tetrapod postcranial elements with pathologies (8 scan datasets as .zip archives):<br>1. Crassigyrinus NHMUKVPR10000_healed_rib_fragment<br>2. Crassigyrinus NMSG1984.15.1ABC L fibula, L ilium, L femur<br>3. Crassigyrinus NMSG1984.15.2 metatarsal pathology<br>4. Crassigyrinus NMSG1984.15.3_L ischium R tibia R fibula, presacral rib<br>5. Crassigyrinus NHMUK R1000_rib fragment_high resolution: sampled_every_5th slice6. Crassigyrinus NMSG1984.15.3 tibia_proximal_only_higher_resolution7. Eoherpeton NMS G 1993.56.25 R fibula distal section high resolution<br>8. Eoherpeton R_fibula &b Neural Arches_1993.56.25, 33A &33B_8bit<br>
DOI: 10.6084/m9.figshare.9211592
title: mosq_phageOTU.fasta

description: phage contigs fasta file
DOI: 10.6084/m9.figshare.9211580
title: mosqGua2_EuVirus.fasta

description: eukaryotic virus fasta file
DOI: 10.6084/m9.figshare.9211592.v1
title: mosq_phageOTU.fasta

description: phage contigs fasta file
DOI: 10.6084/m9.figshare.9211643.v2
title: Tetrapod uCT scan data: pathologies

description: from this paper:Herbst, E.C., Doube, M., Smithson, T.R., Clack, J.A., Hutchinson, J.R. 2019. Bony lesions in early tetrapods and the evolution of mineralized tissue repair. Paleobiology, in press. <br>see table in supp info for more specimen metadata: doi:10.5061/dryad.30kp1qg<br>Crassigyrinus and Eoherpeton early tetrapod postcranial elements with pathologies (8 scan datasets as .zip archives):<br>1. Crassigyrinus NHMUKVPR10000_healed_rib_fragment<br>2. Crassigyrinus NMSG1984.15.1ABC L fibula, L ilium, L femur<br>3. Crassigyrinus NMSG1984.15.2 metatarsal pathology<br>4. Crassigyrinus NMSG1984.15.3_L ischium R tibia R fibula, presacral rib<br>5. Crassigyrinus NHMUK R1000_rib fragment_high resolution: sampled_every_5th slice6. Crassigyrinus NMSG1984.15.3 tibia_proximal_only_higher_resolution7. Eoherpeton NMS G 1993.56.25 R fibula distal section high resolution<br>8. Eoherpeton R_fibula &b Neural Arches_1993.56.25, 33A &33B_8bit<br>
DOI: 10.6084/m9.figshare.9211553
title: features and label

description: The speech features extracted from the Killer corpus and corresponding label
DOI: 10.6084/m9.figshare.9211580.v1
title: mosqGua2_EuVirus.fasta

description: eukaryotic virus fasta file