cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12601345.v1
title: Biologically-based models of cancer risk in radiation research

description: Purpose: In radiation risk analysis the state-of-the-art approach is based on descriptive models which link excess rates of cancer incidence and mortality to radiation exposure by statistical association. To estimate the number of sporadic and radiation-induced cases descriptive models apply parametric dose response function which directly determine the radiation risk. In biologically-based models of cancer risk (BBCR models) dose responses are implemented for key events on the biological level such as early mutations or clonal expansion of initiated cells. Influenced by radiation these events then shape the risk response on the epidemiological level. Although BBCR models facilitate a more comprehensive consideration of biological processes for risk assessment, their range of application in radiation research remains limited. Therefore, we emphasize their ability to improve understanding of radiation-related carcinogenesis by integrating molecular biology with epidemiology. We highlight the potential of BBCR models to harness information from adverse outcome pathways (AOPs) for risk estimation with closer links to radiobiology. The AOP concept originates from toxicology and may be applied profitably in radiation research. Conclusion: The conceptual design of BBCR models can be guided by the high-dimensional data environment provided by AOPs. Risk estimates from BBCR models pertain not only to classical radioepidemiological covariables such as radiation dose or attained age but also to well characterized molecular pathways. By additionally deploying biological information BBCR models facilitate finer risk stratification for a more personalized risk assessment. They leave behind the one-size-fits-all approach of descriptive modeling with the downside of more involved model development. Importantly, predictions from BBCR models can be validated against molecular measurements. Validated predictions would confirm the model design and strengthen the link between molecular biology and epidemiology. But the availability of cancer tissue in good quality from patients with known radiation exposure constitutes a major bottleneck. More ambitious initiative is needed to recover stored tissue samples and make them available for molecular investigations. To conclude, risk estimation will not only on rely on statistical association but will be quantitatively informed with radiobiological insight. Combined with the AOP framework BBCR models could improve accuracy and reduce uncertainty of radiation risk estimates in future research.
DOI: 10.6084/m9.figshare.12601246
title: Airborne particulate matter from goat farm increases acute allergic airway responses in mice

description: <b>Background:</b> Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses. <b>Methods:</b> Fine (&lt;2.5 μm) BioPM was collected from an indoor goat stable. Female BALB/c mice were ovalbumin (OVA) sensitized and challenged with OVA or saline as control. The OVA and saline groups were divided in sub-groups and exposed intranasally to different concentrations (0, 0.9, 3, or 9 μg) of goat farm BioPM. Bronchoalveolar lavage fluid (BALF), blood and lung tissues were collected. <b>Results:</b> In saline-challenged mice, goat farm BioPM induced 1) a dose-dependent increase in neutrophils in BALF and 2) production of macrophage inflammatory protein-3a. In OVA-challenged mice, BioPM induced 1) inflammatory cells in BALF, 2) OVA-specific Immunoglobulin (Ig)G1, 3) airway mucus secretion-specific gene expression. RNAseq analysis of lungs indicates that neutrophil chemotaxis and oxidation-reduction processes were the representative genomic pathways in saline and OVA-challenged mice, respectively. <b>Conclusions:</b> A single exposure to goat farm BioPM enhanced airway inflammation in both saline and OVA-challenged allergic mice, with neutrophilic response as Th17 disorder and eosinophilic response as Th2 disorder indicative of the severity of allergic responses. Identification of the mode of action by which farm PM interacts with airway allergic pathways will be useful to design potential therapeutic approaches.
DOI: 10.6084/m9.figshare.12601246.v1
title: Airborne particulate matter from goat farm increases acute allergic airway responses in mice

description: <b>Background:</b> Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses. <b>Methods:</b> Fine (&lt;2.5 μm) BioPM was collected from an indoor goat stable. Female BALB/c mice were ovalbumin (OVA) sensitized and challenged with OVA or saline as control. The OVA and saline groups were divided in sub-groups and exposed intranasally to different concentrations (0, 0.9, 3, or 9 μg) of goat farm BioPM. Bronchoalveolar lavage fluid (BALF), blood and lung tissues were collected. <b>Results:</b> In saline-challenged mice, goat farm BioPM induced 1) a dose-dependent increase in neutrophils in BALF and 2) production of macrophage inflammatory protein-3a. In OVA-challenged mice, BioPM induced 1) inflammatory cells in BALF, 2) OVA-specific Immunoglobulin (Ig)G1, 3) airway mucus secretion-specific gene expression. RNAseq analysis of lungs indicates that neutrophil chemotaxis and oxidation-reduction processes were the representative genomic pathways in saline and OVA-challenged mice, respectively. <b>Conclusions:</b> A single exposure to goat farm BioPM enhanced airway inflammation in both saline and OVA-challenged allergic mice, with neutrophilic response as Th17 disorder and eosinophilic response as Th2 disorder indicative of the severity of allergic responses. Identification of the mode of action by which farm PM interacts with airway allergic pathways will be useful to design potential therapeutic approaches.
DOI: 10.6084/m9.figshare.12601205
title: Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity

description: This dataset contains data that was used for calculating quantum yields of fluorescent proteins for the publication entitled "Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity" by Ruhlandt et al. as well as the matlab routine for their analysis.<br>
DOI: 10.6084/m9.figshare.12601205.v1
title: Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity

description: This dataset contains data that was used for calculating quantum yields of fluorescent proteins for the publication entitled "Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity" by Ruhlandt et al. as well as the matlab routine for their analysis.<br>
DOI: 10.17028/rd.lboro.12601190
title: Supplementary information files for article: Direct detection of whole bacteria using a nonlinear acoustic resonator

description: Direct detection of whole vegetative bacteria was investigated employing a quartz crystal resonator (QCR) in its nonlinear regime. Escherichia coli (E. coli) in buffer solution under flow was captured on a QCR in a microfluidic cell using a whole-cell anti-E.coli aptamer. The nonlinear distortion in QCR response due to the ‘pull’ from surface-bound bacteria was measured in realtime as the change in third Fourier harmonic (3f) current and compared with shifts in the traditional acoustic parameters of resonance frequency and dissipation. The change in 3f current showed superior quantitative correlation with E. coli concentrations (105-108 cfu/mL) and at least an order of magnitude better sensitivity than shifts in the traditional acoustic parameters. Most interestingly, underpinned by the strength of bacteria-QCR pull, the nonlinear acoustic principle demonstrated a unique specificity in transduction, even in a mixed sample with another gram-negative bacteria, that can supplement the specificity of the bioreceptors. An analytical expression was derived to quantitatively relate the competing influence of shifts in dissipation and nonlinearity coefficient of the QCR on the change in 3f current. This study demonstrates the potential for reliable direct readout of bioreceptor-mediated binding of whole vegetative bacteria from complex samples using a nonlinear acoustic resonator.
DOI: 10.17028/rd.lboro.12601190.v1
title: Supplementary information files for article: Direct detection of whole bacteria using a nonlinear acoustic resonator

description: Direct detection of whole vegetative bacteria was investigated employing a quartz crystal resonator (QCR) in its nonlinear regime. Escherichia coli (E. coli) in buffer solution under flow was captured on a QCR in a microfluidic cell using a whole-cell anti-E.coli aptamer. The nonlinear distortion in QCR response due to the ‘pull’ from surface-bound bacteria was measured in realtime as the change in third Fourier harmonic (3f) current and compared with shifts in the traditional acoustic parameters of resonance frequency and dissipation. The change in 3f current showed superior quantitative correlation with E. coli concentrations (105-108 cfu/mL) and at least an order of magnitude better sensitivity than shifts in the traditional acoustic parameters. Most interestingly, underpinned by the strength of bacteria-QCR pull, the nonlinear acoustic principle demonstrated a unique specificity in transduction, even in a mixed sample with another gram-negative bacteria, that can supplement the specificity of the bioreceptors. An analytical expression was derived to quantitatively relate the competing influence of shifts in dissipation and nonlinearity coefficient of the QCR on the change in 3f current. This study demonstrates the potential for reliable direct readout of bioreceptor-mediated binding of whole vegetative bacteria from complex samples using a nonlinear acoustic resonator.
DOI: 10.6084/m9.figshare.12600521
title: 20m and 3m

description: 20m and 3m databy CSAT3 3D Sonic Anemometer,<br>at the edge of the Tengger Desert,China(103.92E, 37.75N),<br>from Aug. 2014 to Oct. 2015.<br>Data are .mat
DOI: 10.6084/m9.figshare.12600521.v1
title: 20m and 3m

description: 20m and 3m databy CSAT3 3D Sonic Anemometer,<br>at the edge of the Tengger Desert,China(103.92E, 37.75N),<br>from Aug. 2014 to Oct. 2015.<br>Data are .mat
DOI: 10.6084/m9.figshare.12600458
title: Clinic value of nedaplatin in nasopharyngeal carcinoma

description: These files are the available data for the research of comparison between nedaplatin and cisplatin in triple-drug induction chemotherapy for locoregional advanced nasopharyngeal carcinoma".<br>
DOI: 10.6084/m9.figshare.12600500.v1
title: The glucosinolates and their bioactive derivatives in <i>Brassica</i>: a review on classification, biosynthesis and content in plant tissues, fate during and after processing, effect on the human organism and interaction with the gut microbiota

description: The present study is a systematic review of the scientific literature reporting content, composition and biosynthesis of glucosinolates (GLS), and their derivative compounds in <i>Brassica</i> family. An amended classification of brassica species, varieties and their GLS content, organized for the different plant organs and in uniformed concentration measure unit, is here reported for the first time in a harmonized and comparative manner. In the last years, the studies carried out on the effect of processing on vegetables and the potential benefits for human health has increased rapidly and consistently the knowledge on the topic. Therefore, there was the need for an updated revision of the scientific literature of pre- and post-harvest modifications of GLS content, along with the role of gut microbiota in influencing their bioavailability once they are ingested. After analyzing and standardizing over 100 articles and the related data, the highest GLS content in <i>Brassica</i>, was declared in <i>B. nigra</i> (L.) W. D. J. Koch (201.95 ± 53.36 µmol g<sup>−1</sup>), followed by <i>B. oleracea</i> Alboglabra group (180.9 ± 70.3 µmol g<sup>−1</sup>). The authors also conclude that food processing can influence significantly the final content of GLS, considering the most popular methods: boiling, blanching, steaming, the latter can be considered as the most favorable to preserve highest level of GLS and their deriviatives. Therefore, a mild-processing strategic approach for GLS or their derivatives in food is recommended, in order to minimize the loss of actual bioactive impact. Finally, the human gut microbiota is influenced by Brassica-rich diet and can contribute in certain conditions to the increasing of GLS bioavailability but further studies are needed to assess the actual role of microbiomes in the bioavailability of healthy glucosinolate derivatives.
DOI: 10.6084/m9.figshare.12600281
title: Metadata record for: A comprehensive, multisource database for hydrometeorological modeling of 14,425 North American watersheds

description: This dataset contains key characteristics about the data described in the Data Descriptor A comprehensive, multisource database for hydrometeorological modeling of 14,425 North American watersheds. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12600281.v1
title: Metadata record for: A comprehensive, multisource database for hydrometeorological modeling of 14,425 North American watersheds

description: This dataset contains key characteristics about the data described in the Data Descriptor A comprehensive, multisource database for hydrometeorological modeling of 14,425 North American watersheds. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.12600188
title: Supplementary Material for: Attention Deficit Hyperactivity Disorder in Prisoners: Increased Substance Use Disorder Severity and Psychiatric Comorbidity

description: <b><i>Objectives:</i></b> Attention deficit hyperactivity disorder (ADHD) and substance use disorders (SUD) are overrepresented among incarcerated populations. We examined whether ADHD was associated with increased severity of comorbid SUD and with increased psychiatric comorbidity among prisoners. <b><i>Methods:</i></b> Cross-sectional study of 500 randomly selected Latino male prisoners in the Puerto Rico Correctional System using validated diagnostic measures to assess <i>Diagnostic and Statistical Manual of Mental Disorders</i>, fifth edition (DSM-5) ADHD and SUD diagnosis, antisocial personality disorder (ASP) and borderline personality disorder (BPD), major depression, and generalized anxiety disorder (GAD). We defined SUD severity by symptom count and by presence of at least 2 current SUD diagnoses (polysubstance). <b><i>Results:</i></b> Participants with ADHD had increased risk for lifetime (<i>p</i> &lt; 0.05) and current (<i>p</i> &lt; 0.01) SUDs, all comorbid psychiatric disorders, and suicidality (<i>p</i> &lt; 0.001). They had more severe SUD, both in number of symptoms and number of SUD (polysubstance) diagnoses (<i>p</i> &lt; 0.01). ADHD was associated with increased psychiatric comorbidity, as participants with ADHD were more likely to have a second diagnosis, and a greater number of comorbid disorders (<i>p</i> &lt; 0.001). ASP, BPD, major depression, and GAD, but not ADHD, were significant predictors of SUD severity in adjusted models. <b><i>Conclusions:</i></b> Findings highlight the complex mental health needs of incarcerated populations, where SUD, ADHD, and other psychiatric disorders are prevalent and interrelated.
DOI: 10.6084/m9.figshare.12600203
title: Supplementary Material for: Predictive Factors for Changes in Quality of Life after Steroid Treatment for Active Moderate-to-Severe Graves’ Orbitopathy: A Prospective Trial

description: <b><i>Objectives:</i></b> To investigate the predictive factors for changes in the quality of life (GO-QoL) of patients with Graves’ orbitopathy (GO) prior to and after specific treatment. <b><i>Methods:</i></b> A prospective follow-up study was conducted at an academic tertiary referral orbital center with a joint thyroid-eye clinic on 100 consecutive patients with GO. Before and after the standard 12-week course of weekly intravenous methylprednisolone (cumulative dose 4.5 g), the GO-QoL questionnaire provided by the European Group on Graves’ Orbitopathy (EUGOGO) was completed. Endocrine and ophthalmic assessments were performed at each visit. <b><i>Results:</i></b> All patients were biochemically euthyroid and untreated for GO at baseline and presented with active and moderate-to-severe disease. Both GO-QoL subscales (visual functioning [VF] and appearance [AP]) significantly increased after immunosuppressive therapy and showed a sustained improvement for 6 months. At baseline, demographic variables (sex, age, and smoking) influenced QoL in the stepwise linear regression (<i>p</i> &lt; 0.01, adjusted <i>R</i><sup>2</sup> = 0.24 for VF and <i>p</i> &lt; 0.01, adjusted <i>R</i><sup>2</sup> = 0.21 for AP). In contrast, 6 months after treatment, the improved QoL was now exclusively associated with ophthalmic parameters (<i>p</i> &lt; 0.01, adjusted <i>R</i><sup>2</sup> = 0.47 for VF; <i>p</i> &lt; 0.01, adjusted <i>R</i><sup>2</sup> = 0.23 for AP). <b><i>Conclusions:</i></b> Predictive factors for GO-QoL differed not only between the 2 subscales but also before and after the first treatment of GO.
DOI: 10.6084/m9.figshare.12600155
title: Trimmed NGS reads of perennial Helianthus species

description: Semi-raw NGS data (trimmed reads) of seven perennial <i>Helianthus</i> species. Namely, <i>H. pauciflorus</i>, <i>H. microcephalis</i>, <i>H. strumosus</i>, <i>H. grosseserratus</i>, <i>H. tuberosus</i>, <i>H. hirsutus</i>, and <i>H. salicifolius</i> were sequenced.
DOI: 10.6084/m9.figshare.12600146
title: Data and R code for constructing bird and insect seasonal trend recorded by radar

description: Featall.Rdata：dataset used to generate the results, including the MTR calculated for both birds and insects.01_MTR_tidy.Rmd: R script to combine bird and insect data & remove precipitation and technical contamination02_M_L_separation.Rmd: R script to calculate proportion o migration for each day/night and estimate total n. of birds and insects per year03_trend_construction.Rmd<b>:</b> R script to construct and plot trend of animal movement<br>04_phenology_figs.Rmd: R script to plot flight direction (Fig. 2) and proportion of migration (Fig. S1)
DOI: 10.6084/m9.figshare.12600128
title: sequence data for ERG11 gene

description: the current data set are the F and R sequence data for ERG11 gene from a fluconazole resistant Candida albicans. three non-synonym mutation was detected in the 4 isolates (E116D, D266E, and V488I ).
DOI: 10.6084/m9.figshare.12600056
title: Data from: Incidental findings on computed tomography coronary angiography and its impact on respiratory services in a United Kingdom district general hospital.

description: Data from: Incidental findings on computed tomography coronary angiography and its impact on respiratory services in a United Kingdom district general hospital. <br><br>Some data could not be shared due to data protection rules such as age, date of imaging and date of birth.<br>
DOI: 10.6084/m9.figshare.12600056.v1
title: Data from: Incidental findings on computed tomography coronary angiography and its impact on respiratory services in a United Kingdom district general hospital.

description: Data from: Incidental findings on computed tomography coronary angiography and its impact on respiratory services in a United Kingdom district general hospital. <br><br>Some data could not be share due to data protection rules such as age, date of imaging and date of birth.<br>
DOI: 10.6084/m9.figshare.12600056.v2
title: Data from: Incidental findings on computed tomography coronary angiography and its impact on respiratory services in a United Kingdom district general hospital.

description: Data from: Incidental findings on computed tomography coronary angiography and its impact on respiratory services in a United Kingdom district general hospital. <br><br>Some data could not be shared due to data protection rules such as age, date of imaging and date of birth.<br>
DOI: 10.6084/m9.figshare.12599978
title: Supplementary Material for: Atrial and Ventricular Deformation Analysis in Normal Fetal Hearts Using Two-Dimensional Speckle Tracking Echocardiography

description: <b><i>Objective:</i></b> Two-dimensional speckle tracking echocardiography (2D-STE)-based strain values of the left and the right ventricle have been established; however, less is known about atrial deformation. The aim of our study was to assess both atrial strain and ventricular strain using 2D-STE in a cardiac 4-chamber view and to investigate the effect of possible influencing factors such as gestational age. <b><i>Methods:</i></b> Fetal echocardiography was performed on a Toshiba Aplio 500 ultrasound system. Based on an apical or basal 4-chamber view of the fetal heart, left and right ventricular longitudinal peak systolic strain (LVLPSS and RVLPSS) as well as left and right atrial longitudinal peak systolic strain (LALPSS and RALPSS) were assessed by 2D-STE. <b><i>Results:</i></b> A total of 101 healthy fetuses were included. The mean gestational age (GA) was 26.0 ± 5.6 weeks. GA was significantly positively correlated (<i>p</i> &lt; 0.05) with LVLPSS and RVLPSS and significantly negatively correlated (<i>p</i> &lt; 0.05) with LALPSS and RALPSS. The mean values for LVLPSS and RVLPSS were −17.44 ± 2.29% and −16.89 ± 1.72%. The mean values for LALPSS and RALPSS were 34.09 ± 4.17% and 35.36 ± 2.90%. <b><i>Conclusion:</i></b> Ventricular and atrial deformation analysis in 2D-STE was technically feasible and showed comparable values to current data. For future research on myocardial function (MF) of the fetus, considering GA as an influencing factor for deformation analysis seems to be adequate. Especially, atrial deformation analysis allows the assessment of diastolic myocardial function. Further research needs to clarify the clinical meaning of these myocardial deformation indices in fetuses at risk.
DOI: 10.6084/m9.figshare.12599966
title: Metadata record for: Combining expert and crowd-sourced training data to map urban form and functions for the continental US

description: This dataset contains key characteristics about the data described in the Data Descriptor Combining expert and crowd-sourced training data to map urban form and functions for the continental US. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.12599966.v1
title: Metadata record for: Combining expert and crowd-sourced training data to map urban form and functions for the continental US

description: This dataset contains key characteristics about the data described in the Data Descriptor Combining expert and crowd-sourced training data to map urban form and functions for the continental US. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.12599900
title: Maldi-TOF spectra of identified skin microorganisms

description: <b>Investigation of skin microbiota reveals <i>Mycobacterium ulcerans</i>-<i>Aspergillus</i> sp. trans-kingdom communication.</b><b>Maldi-TOF spectra of identified skin microorganisms </b>
DOI: 10.6084/m9.figshare.12599834
title: Facefig.xlsx

description: Elevated CO2 applied to open woodland, data contains raw abundance for soil invertebrates and associated environmental soil parameters and aboveground vegetation cover collected at 37 and 40 months following commencement of eCO2 treatment.