cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31026187
title: Supplementary Material for: Therapeutic keratoplasty for large diameter bilateral corneal melts secondary to gonococcal keratoconjunctivitis: A case report

description: Introduction: Neisseria gonorrhoeae is a common communicable bacterial infection in the U.S. Although primarily affecting the genitourinary tract, ocular involvement—gonococcal keratoconjunctivitis—is a rare but potentially devastating manifestation that can result in corneal melt, perforation, and permanent vision loss. The management of gonococcal keratoconjunctivitis is typically medical, but surgical intervention is warranted in severe cases. 
Case Presentation: This case details the delayed presentation of a 49-year-old male with gonococcal keratoconjunctivitis leading to bilateral 9 x 10 mm full thickness corneal melts, with unsuccessful corneal gluing prior to transfer. On presentation, examination showed excessive purulence, glue, and disorganized anterior chamber structures, and bilaterally collapsed globes on CT. Vision was at least light perception in both eyes. Given the severity of the disease, the ability to preserve the globes was uncertain, therefore the decision was made to undertake urgent and aggressive medical and surgical intervention with bilateral simultaneous penetrating keratoplasty (PK), which successfully salvaged both globes. At most recent follow-up, the exam showed a visual acuity (VA) of 20/150 with pinhole in the right and a failed graft with light perception in the left.
Conclusion: This case demonstrates the potential severity of gonococcal keratoconjunctivitis and highlights the utility of early and aggressive surgical intervention in such cases. Therapeutic keratoplasty along with amniotic membrane provided an effective method of treating gonococcal-associated corneal melt and perforation, allowing for salvage of both globes. While the severity of this case is uncommon, it provides a precedent for the role of therapeutic keratoplasty in similar situations.
DOI: 10.6084/m9.figshare.31026187.v1
title: Supplementary Material for: Therapeutic keratoplasty for large diameter bilateral corneal melts secondary to gonococcal keratoconjunctivitis: A case report

description: Introduction: Neisseria gonorrhoeae is a common communicable bacterial infection in the U.S. Although primarily affecting the genitourinary tract, ocular involvement—gonococcal keratoconjunctivitis—is a rare but potentially devastating manifestation that can result in corneal melt, perforation, and permanent vision loss. The management of gonococcal keratoconjunctivitis is typically medical, but surgical intervention is warranted in severe cases. 
Case Presentation: This case details the delayed presentation of a 49-year-old male with gonococcal keratoconjunctivitis leading to bilateral 9 x 10 mm full thickness corneal melts, with unsuccessful corneal gluing prior to transfer. On presentation, examination showed excessive purulence, glue, and disorganized anterior chamber structures, and bilaterally collapsed globes on CT. Vision was at least light perception in both eyes. Given the severity of the disease, the ability to preserve the globes was uncertain, therefore the decision was made to undertake urgent and aggressive medical and surgical intervention with bilateral simultaneous penetrating keratoplasty (PK), which successfully salvaged both globes. At most recent follow-up, the exam showed a visual acuity (VA) of 20/150 with pinhole in the right and a failed graft with light perception in the left.
Conclusion: This case demonstrates the potential severity of gonococcal keratoconjunctivitis and highlights the utility of early and aggressive surgical intervention in such cases. Therapeutic keratoplasty along with amniotic membrane provided an effective method of treating gonococcal-associated corneal melt and perforation, allowing for salvage of both globes. While the severity of this case is uncommon, it provides a precedent for the role of therapeutic keratoplasty in similar situations.
DOI: 10.6084/m9.figshare.31026190
title: Supplementary Material for: Longitudinal Observation of Children With Achondroplasia: Findings From a Global Natural History Study (ACHieve)

description: Introduction: The ACHieve study assessed growth velocity, body proportionality, and clinical events in children with achondroplasia not receiving growth-promoting therapy. 
Methods: ACHieve was a global, longitudinal, prospective, observational study. Children ≤8 years old with achondroplasia were enrolled and evaluated every 6 months for anthropometric parameters and clinical events. 
Results: ACHieve enrolled 259 children in 15 countries, including 83 from China. Median follow-up was 21 months; median age of diagnosis was approximately 52 weeks in China and 2 weeks elsewhere. Growth parameters were similar regardless of region. Mean annualized growth velocity (AGV) was 9.3 cm/year for males and 10.4 cm/year for females at age 1 and decreased to 4.1 cm/year and 4.6 cm/year, respectively, at age 4. Upper-to-lower-body segment ratio was generally consistent across regions. Overall, 77.2% of participants experienced clinical events, 34.0% of which were considered related to achondroplasia. Two deaths occurred (one accident and one cardiac arrest of unknown origin). 
Conclusion: ACHieve was one of the largest longitudinal natural history studies of achondroplasia to date and included the largest prospective Chinese achondroplasia cohort. The results demonstrated common trajectories in growth parameters regardless of region, indicating the generalizability of findings.
DOI: 10.6084/m9.figshare.31026190.v1
title: Supplementary Material for: Longitudinal Observation of Children With Achondroplasia: Findings From a Global Natural History Study (ACHieve)

description: Introduction: The ACHieve study assessed growth velocity, body proportionality, and clinical events in children with achondroplasia not receiving growth-promoting therapy. 
Methods: ACHieve was a global, longitudinal, prospective, observational study. Children ≤8 years old with achondroplasia were enrolled and evaluated every 6 months for anthropometric parameters and clinical events. 
Results: ACHieve enrolled 259 children in 15 countries, including 83 from China. Median follow-up was 21 months; median age of diagnosis was approximately 52 weeks in China and 2 weeks elsewhere. Growth parameters were similar regardless of region. Mean annualized growth velocity (AGV) was 9.3 cm/year for males and 10.4 cm/year for females at age 1 and decreased to 4.1 cm/year and 4.6 cm/year, respectively, at age 4. Upper-to-lower-body segment ratio was generally consistent across regions. Overall, 77.2% of participants experienced clinical events, 34.0% of which were considered related to achondroplasia. Two deaths occurred (one accident and one cardiac arrest of unknown origin). 
Conclusion: ACHieve was one of the largest longitudinal natural history studies of achondroplasia to date and included the largest prospective Chinese achondroplasia cohort. The results demonstrated common trajectories in growth parameters regardless of region, indicating the generalizability of findings.
DOI: 10.6084/m9.figshare.31026193
title: Supplementary Material for: Association between antihistamine use and clinical outcomes in patients on maintenance hemodialysis

description: Introduction: H1-antihistamines are frequently used to treat pruritus in patients on dialysis, but their safety remains unclear. This study aimed to evaluate the effects of H1-antihistamine use on outcomes in patients undergoing maintenance hemodialysis (HD).
Methods: This retrospective cohort study included adult patients undergoing HD identified through national HD quality assessment programs. Patients were grouped by H1-antihistamine use over 6 months: No prescription, Short (&lt;60 days), and Long (≥60 days) groups. Outcomes included all-cause mortality, cardiovascular events (CVE), atrial fibrillation (AF), dementia, and Parkinson’s disease. Cox regression was used to estimate hazard ratios (HRs).
Results: Among 71,540 patients, 22.9%, 34.4%, and 42.6% were classified into the No prescription, Short, and Long groups, respectively. H1-antihistamine use was associated with higher risks of adverse outcomes, with significantly greater HRs in the Long group than in the Short group. Compared to the No prescription group, the adjusted HRs (95% confidence interval) in the Long group were 1.12 (1.08–1.15) for all-cause mortality, 1.17 (1.12–1.23) for CVE, 1.06 (1.01–1.12) for AF, 1.31 (1.23–1.41) for dementia, and 1.47 (1.30–1.67) for Parkinson’s disease. These associations remained consistent irrespective of insomnia status, except for AF, where increased risk was only observed in patients without insomnia. First-generation antihistamines were linked to greater risks of all-cause mortality, CVE, and dementia, but not for AF and Parkinson’s disease, compared to second-generation agents.
Conclusions: H1-antihistamine use, particularly long-term use and first-generation agents was associated with increased risks of adverse outcomes in patients undergoing HD. These findings suggest that antihistamine use may represent a potential risk marker in this population; however, the observed associations may reflect the presence or severity of pruritus rather than that of a direct causal effect.
DOI: 10.6084/m9.figshare.31026193.v1
title: Supplementary Material for: Association between antihistamine use and clinical outcomes in patients on maintenance hemodialysis

description: Introduction: H1-antihistamines are frequently used to treat pruritus in patients on dialysis, but their safety remains unclear. This study aimed to evaluate the effects of H1-antihistamine use on outcomes in patients undergoing maintenance hemodialysis (HD).
Methods: This retrospective cohort study included adult patients undergoing HD identified through national HD quality assessment programs. Patients were grouped by H1-antihistamine use over 6 months: No prescription, Short (&lt;60 days), and Long (≥60 days) groups. Outcomes included all-cause mortality, cardiovascular events (CVE), atrial fibrillation (AF), dementia, and Parkinson’s disease. Cox regression was used to estimate hazard ratios (HRs).
Results: Among 71,540 patients, 22.9%, 34.4%, and 42.6% were classified into the No prescription, Short, and Long groups, respectively. H1-antihistamine use was associated with higher risks of adverse outcomes, with significantly greater HRs in the Long group than in the Short group. Compared to the No prescription group, the adjusted HRs (95% confidence interval) in the Long group were 1.12 (1.08–1.15) for all-cause mortality, 1.17 (1.12–1.23) for CVE, 1.06 (1.01–1.12) for AF, 1.31 (1.23–1.41) for dementia, and 1.47 (1.30–1.67) for Parkinson’s disease. These associations remained consistent irrespective of insomnia status, except for AF, where increased risk was only observed in patients without insomnia. First-generation antihistamines were linked to greater risks of all-cause mortality, CVE, and dementia, but not for AF and Parkinson’s disease, compared to second-generation agents.
Conclusions: H1-antihistamine use, particularly long-term use and first-generation agents was associated with increased risks of adverse outcomes in patients undergoing HD. These findings suggest that antihistamine use may represent a potential risk marker in this population; however, the observed associations may reflect the presence or severity of pruritus rather than that of a direct causal effect.
DOI: 10.15468/dl.sv4fbf
title: Occurrence Download

description: A dataset containing 4460 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Iran (Islamic Republic of)",
 "IsInCluster is true",
 "Issue is one of (Geodetic datum assumed WGS84, Coordinate rounded, Country coordinate mismatch, Country derived from coordinates)",
 "Year 2001-2026"
 ]
}

 The dataset includes 4460 records from 151 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081164-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2y45uu
title: Occurrence Download

description: A dataset containing 6202 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "NetworkKey is 99d66b6c-9087-452f-a9d4-f15f2c2d0e7e",
 "TaxonKey is Chordata"
 ]
 },
 {
 "and" : [
 "TaxonKey is one of (Tursiops [GBIF Backbone Taxonomy], Pseudorca [GBIF Backbone Taxonomy], Sousa [GBIF Backbone Taxonomy])",
 "BasisOfRecord is one of (Specimen, Fossil)"
 ]
 }
 ]
}

 The dataset includes 6202 records from 78 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0081163-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15156/bio/sh0152335.10fu
title: SH0152335.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152336.10fu
title: SH0152336.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152337.10fu
title: SH0152337.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152338.10fu
title: SH0152338.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152339.10fu
title: SH0152339.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.5281/zenodo.16885126
title: Supplementary data for "Modelling Hydro-Ice-Thermal Dynamics in Open Channels by a Double Layer-Averaged Model"
DOI: 10.5281/zenodo.18184295
title: Supplementary data for "Modelling Hydro-Ice-Thermal Dynamics in Open Channels by a Double Layer-Averaged Model"
DOI: 10.15156/bio/sh0152340.10fu
title: SH0152340.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152341.10fu
title: SH0152341.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152342.10fu
title: SH0152342.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0152343.10fu
title: SH0152343.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.