cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16780108
title: miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2

description: Previous studies have explored the association between protein-coding genes and microRNAs (miRNAs) in lung adenocarcinoma (LUAD). However, the influence of the miR-199a-3p/anterior gradient 2 (AGR2) axis in LUAD has not yet been fully explored. Therefore, this study aimed to examine the underlying roles of AGR2 and miR-199a-3p in the development of LUAD. The expression levels of miR-199a-3p and AGR2 in LUAD tissues and cells were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A luciferase assay was also performed to identify the interaction between AGR2 and miR-199a-3p. Moreover, the cell counting kit 8 (CCK-8), 5ʹ-bromo-2ʹ-deoxyuridine (BrdU), and adhesion assays were used along with flow cytometry to verify the malignancy of LUAD in vitro, while a xenograft tumor assay was performed to confirm the tumor growth in vitro. The findings showed a decrease in the expression of miR-199a-3p in LUAD. Additionally, miR-199a-3p overexpression inhibited the growth of LUAD cells in vitro and in vivo, while elevating the apoptosis rate of the cells. AGR2 knockdown had the same effect in the cells as that of miR-199a-3p overexpression. It was also found that miR-199a-3p directly targeted AGR2 in LUAD cells to suppress tumorigenesis. In conclusion, this study suggests that miR-199a-3p plays an anti-tumorigenic role in LUAD by targeting AGR2. Moreover, our study provides insights into the development of novel therapeutic targets for the treatment of LUAD.
DOI: 10.6084/m9.figshare.16780108.v2
title: miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2

description: Previous studies have explored the association between protein-coding genes and microRNAs (miRNAs) in lung adenocarcinoma (LUAD). However, the influence of the miR-199a-3p/anterior gradient 2 (AGR2) axis in LUAD has not yet been fully explored. Therefore, this study aimed to examine the underlying roles of AGR2 and miR-199a-3p in the development of LUAD. The expression levels of miR-199a-3p and AGR2 in LUAD tissues and cells were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A luciferase assay was also performed to identify the interaction between AGR2 and miR-199a-3p. Moreover, the cell counting kit 8 (CCK-8), 5ʹ-bromo-2ʹ-deoxyuridine (BrdU), and adhesion assays were used along with flow cytometry to verify the malignancy of LUAD in vitro, while a xenograft tumor assay was performed to confirm the tumor growth in vitro. The findings showed a decrease in the expression of miR-199a-3p in LUAD. Additionally, miR-199a-3p overexpression inhibited the growth of LUAD cells in vitro and in vivo, while elevating the apoptosis rate of the cells. AGR2 knockdown had the same effect in the cells as that of miR-199a-3p overexpression. It was also found that miR-199a-3p directly targeted AGR2 in LUAD cells to suppress tumorigenesis. In conclusion, this study suggests that miR-199a-3p plays an anti-tumorigenic role in LUAD by targeting AGR2. Moreover, our study provides insights into the development of novel therapeutic targets for the treatment of LUAD.
DOI: 10.6084/m9.figshare.16780108.v1
title: miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2

description: Previous studies have explored the association between protein-coding genes and microRNAs (miRNAs) in lung adenocarcinoma (LUAD). However, the influence of the miR-199a-3p/anterior gradient 2 (AGR2) axis in LUAD has not yet been fully explored. Therefore, this study aimed to examine the underlying roles of AGR2 and miR-199a-3p in the development of LUAD. The expression levels of miR-199a-3p and AGR2 in LUAD tissues and cells were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A luciferase assay was also performed to identify the interaction between AGR2 and miR-199a-3p. Moreover, the cell counting kit 8 (CCK-8), 5ʹ-bromo-2ʹ-deoxyuridine (BrdU), and adhesion assays were used along with flow cytometry to verify the malignancy of LUAD in vitro, while a xenograft tumor assay was performed to confirm the tumor growth in vitro. The findings showed a decrease in the expression of miR-199a-3p in LUAD. Additionally, miR-199a-3p overexpression inhibited the growth of LUAD cells in vitro and in vivo, while elevating the apoptosis rate of the cells. AGR2 knockdown had the same effect in the cells as that of miR-199a-3p overexpression. It was also found that miR-199a-3p directly targeted AGR2 in LUAD cells to suppress tumorigenesis. In conclusion, this study suggests that miR-199a-3p plays an anti-tumorigenic role in LUAD by targeting AGR2. Moreover, our study provides insights into the development of novel therapeutic targets for the treatment of LUAD.
DOI: 10.6084/m9.figshare.13634380
title: Additional file 7 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 7: Table S5. Functional enrichment of GO analysis of CNVR-harbored genes.
DOI: 10.6084/m9.figshare.13634380.v1
title: Additional file 7 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 7: Table S5. Functional enrichment of GO analysis of CNVR-harbored genes.
DOI: 10.6084/m9.figshare.13634383
title: Additional file 8 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 8: Table S6. Functional enrichment of KEGG analysis of CNVR-harbored genes.
DOI: 10.6084/m9.figshare.7867226
title: Additional file 10: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S10. The number of identified phage contigs for each sample in the independent cohort of humans treated with antibiotics. (XLSX 42â KB) (XLSX 41 kb)
DOI: 10.6084/m9.figshare.13634383.v1
title: Additional file 8 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 8: Table S6. Functional enrichment of KEGG analysis of CNVR-harbored genes.
DOI: 10.6084/m9.figshare.7867226.v1
title: Additional file 10: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S10. The number of identified phage contigs for each sample in the independent cohort of humans treated with antibiotics. (XLSX 42â KB) (XLSX 41 kb)
DOI: 10.6084/m9.figshare.13634386
title: Additional file 9 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 9: Table S7. Information about QTLs overlapping with identified CNVRs.
DOI: 10.6084/m9.figshare.13634386.v1
title: Additional file 9 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 9: Table S7. Information about QTLs overlapping with identified CNVRs.
DOI: 10.6084/m9.figshare.7867232
title: Additional file 11: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S11. The list of 122 KO groups and 118 Pfam groups found significantly different (Wilcoxon rank-sum test, pâ &lt;â 0.05) exposed 0 vs exposed 7 using VirMiner. (XLSX 69â KB) (XLSX 66 kb)
DOI: 10.6084/m9.figshare.7867232.v1
title: Additional file 11: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S11. The list of 122 KO groups and 118 Pfam groups found significantly different (Wilcoxon rank-sum test, pâ &lt;â 0.05) exposed 0 vs exposed 7 using VirMiner. (XLSX 69â KB) (XLSX 66 kb)
DOI: 10.6084/m9.figshare.13634389
title: Additional file 1 of Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10

description: Additional file 1: Table S1. Antibody information and vector sequences.
DOI: 10.6084/m9.figshare.13634389.v1
title: Additional file 1 of Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10

description: Additional file 1: Table S1. Antibody information and vector sequences.
DOI: 10.6084/m9.figshare.7867235
title: Additional file 12: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S12. The predicted phage-host interactions in the independent cohort of humans treated with antibiotics at species level. (XLSX 52â KB) (XLSX 40 kb)
DOI: 10.6084/m9.figshare.7867235.v1
title: Additional file 12: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S12. The predicted phage-host interactions in the independent cohort of humans treated with antibiotics at species level. (XLSX 52â KB) (XLSX 40 kb)
DOI: 10.6084/m9.figshare.19925859
title: Effect of central serous chorioretinopathy patients by covering sick eye for 48 hours

description: ABSTRACT Purpose: To assess the effect of continuously covering the sick eye affected with central serous chorioretinopathy for 48 h. Methods: This retrospective, case-control study involved 32 central serous chorioretinopathy patients categorized in the treatment group composed of 17 sick eye that received continuous covering treatment for 48 h with a medical gauze and the observation group composed of 15 of these patients who were followed up. None of the patients received any other treatments or medications. The logarithm of the minimal angle of resolution (logMAR) best-corrected visual acuity, macular retinal thickness, and the root mean square value of the amplitude density in the first ring of multifocal electroretinogram were examined before and after the 48-h treatment. Results: After the continuous treatment, the logMAR best-corrected visual acuities were 0.31 ± 0.18 and 0.56 ± 0.37 in the treatment and observation groups, respectively (p=0.019). The macular retinal thicknesses were 461 ± 43 µm and 498 ± 50 µm in the treatment and observation groups, respectively (p=0.032). The root mean square values of the amplitude density in the first ring of multifocal electroretinogram were 32.5 ± 5.3 nV/deg2 and 26.6 ± 4.3 nV/deg2 in the treatment and observation groups, respectively (p=0.002). Conclusions: The continuous application of the covering treatment for 48 h on the sick eye showed positive outcomes with respect to the best-corrected visual acuity, macular retinal thickness, and macular retina functions in the treatment of central serous chorioretinopathy.
DOI: 10.6084/m9.figshare.19925859.v1
title: Effect of central serous chorioretinopathy patients by covering sick eye for 48 hours

description: ABSTRACT Purpose: To assess the effect of continuously covering the sick eye affected with central serous chorioretinopathy for 48 h. Methods: This retrospective, case-control study involved 32 central serous chorioretinopathy patients categorized in the treatment group composed of 17 sick eye that received continuous covering treatment for 48 h with a medical gauze and the observation group composed of 15 of these patients who were followed up. None of the patients received any other treatments or medications. The logarithm of the minimal angle of resolution (logMAR) best-corrected visual acuity, macular retinal thickness, and the root mean square value of the amplitude density in the first ring of multifocal electroretinogram were examined before and after the 48-h treatment. Results: After the continuous treatment, the logMAR best-corrected visual acuities were 0.31 ± 0.18 and 0.56 ± 0.37 in the treatment and observation groups, respectively (p=0.019). The macular retinal thicknesses were 461 ± 43 µm and 498 ± 50 µm in the treatment and observation groups, respectively (p=0.032). The root mean square values of the amplitude density in the first ring of multifocal electroretinogram were 32.5 ± 5.3 nV/deg2 and 26.6 ± 4.3 nV/deg2 in the treatment and observation groups, respectively (p=0.002). Conclusions: The continuous application of the covering treatment for 48 h on the sick eye showed positive outcomes with respect to the best-corrected visual acuity, macular retinal thickness, and macular retina functions in the treatment of central serous chorioretinopathy.
DOI: 10.6084/m9.figshare.7867244
title: Additional file 13: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S13. The predictive performance of the method for phage contig identification in Paez-Espino et al [24]. (XLSX 47â KB) (XLSX 46 kb)
DOI: 10.6084/m9.figshare.7867244.v1
title: Additional file 13: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S13. The predictive performance of the method for phage contig identification in Paez-Espino et al [24]. (XLSX 47â KB) (XLSX 46 kb)
DOI: 10.6084/m9.figshare.13634406
title: Additional file 4 of Long noncoding RNA SNHG14 promotes hepatocellular carcinoma progression by regulating miR-876-5p/SSR2 axis

description: Additional file 4: Supplementary Figures 4-5. The expression of SSR2 are elevated in HCC tissues compared with adjacent tissues.
DOI: 10.6084/m9.figshare.13634406.v1
title: Additional file 4 of Long noncoding RNA SNHG14 promotes hepatocellular carcinoma progression by regulating miR-876-5p/SSR2 axis

description: Additional file 4: Supplementary Figures 4-5. The expression of SSR2 are elevated in HCC tissues compared with adjacent tissues.
DOI: 10.6084/m9.figshare.7867247
title: MOESM2 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 2: Table S2. All the data in Fig.Â 2a.
DOI: 10.6084/m9.figshare.7867247.v1
title: MOESM2 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 2: Table S2. All the data in Fig.Â 2a.
DOI: 10.6084/m9.figshare.7867253
title: Additional file 14: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S14. The paired viral-microbial metagenomic data from Tara Oceans samples used in this study. (XLSX 47â KB) (XLSX 40 kb)
DOI: 10.6084/m9.figshare.7867253.v1
title: Additional file 14: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S14. The paired viral-microbial metagenomic data from Tara Oceans samples used in this study. (XLSX 47â KB) (XLSX 40 kb)
DOI: 10.6084/m9.figshare.7867256
title: MOESM3 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 3: Dataset S1. Markers for QTL analysis in two parent strains.
DOI: 10.6084/m9.figshare.7867256.v1
title: MOESM3 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 3: Dataset S1. Markers for QTL analysis in two parent strains.
DOI: 10.6084/m9.figshare.7867262
title: Additional file 15: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S15. The predictive performance of VirMiner in the metagenomic data from Tara Oceans samples. (XLSX 69â KB) (XLSX 57 kb)
DOI: 10.24403/jp.1320605
title: Nicotiana ˣmierata und N. ˣobtusiata - zwei neue synthetische Hybriden / Tamara Krügel
DOI: 10.6084/m9.figshare.7867262.v1
title: Additional file 15: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S15. The predictive performance of VirMiner in the metagenomic data from Tara Oceans samples. (XLSX 69â KB) (XLSX 57 kb)
DOI: 10.6084/m9.figshare.7867265
title: MOESM4 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 4: Dataset S2. QTL lists detected by the EXPLoRA and MULTIPOOL methods.
DOI: 10.6084/m9.figshare.7867265.v1
title: MOESM4 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 4: Dataset S2. QTL lists detected by the EXPLoRA and MULTIPOOL methods.
DOI: 10.6084/m9.figshare.7867274
title: Additional file 16: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S16. The predictive performance of the RF model trained with mixed Tara Oceans metagenomic data and human gut samples. (XLSX 46â KB) (XLSX 47 kb)
DOI: 10.6084/m9.figshare.7867274.v1
title: Additional file 16: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S16. The predictive performance of the RF model trained with mixed Tara Oceans metagenomic data and human gut samples. (XLSX 46â KB) (XLSX 47 kb)
DOI: 10.6084/m9.figshare.7867271
title: MOESM5 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 5: Dataset S3. Annotation of SNP variants in major and minor QTLs detected by MULTIPOOL.
DOI: 10.6084/m9.figshare.7867271.v1
title: MOESM5 of QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast

description: Additional file 5: Dataset S3. Annotation of SNP variants in major and minor QTLs detected by MULTIPOOL.
DOI: 10.6084/m9.figshare.7867280
title: Additional file 17: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S17. The predictive performance of the RF model trained only with Tara Oceans metagenomic samples in the human gut samples. (XLSX 48â KB) (XLSX 47 kb)
DOI: 10.6084/m9.figshare.7867280.v1
title: Additional file 17: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S17. The predictive performance of the RF model trained only with Tara Oceans metagenomic samples in the human gut samples. (XLSX 48â KB) (XLSX 47 kb)
DOI: 10.6084/m9.figshare.7867283
title: Additional file 18: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S18. The summary of quality control statistics in the Tara Oceans metagenomic samples and human gut samples that were used for the VirMiner training dataset. (XLSX 48â KB) (XLSX 50 kb)
DOI: 10.6084/m9.figshare.7867283.v1
title: Additional file 18: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S18. The summary of quality control statistics in the Tara Oceans metagenomic samples and human gut samples that were used for the VirMiner training dataset. (XLSX 48â KB) (XLSX 50 kb)
DOI: 10.6084/m9.figshare.7867298
title: MOESM2 of Discovery of potential pathways for biological conversion of poplar wood into lipids by co-fermentation of Rhodococci strains

description: Additional file 2: Table S1. Normalized global proteome data of spectral count for the lysate and secretome samples from glucose or lignin fermentation after 5 days. Each row represents one protein and each column represented one sample. “G1” and “G2” are the duplicate samples from glucose fermentation; “L1” and “L2” are the duplicate samples from lignin fermentation. All the fermentation was conducted by co-culture of three strains: R. jostii RHA1, R. jostii RHA1 vanA−, R. opacus PD630.
DOI: 10.6084/m9.figshare.7867298.v1
title: MOESM2 of Discovery of potential pathways for biological conversion of poplar wood into lipids by co-fermentation of Rhodococci strains

description: Additional file 2: Table S1. Normalized global proteome data of spectral count for the lysate and secretome samples from glucose or lignin fermentation after 5 days. Each row represents one protein and each column represented one sample. “G1” and “G2” are the duplicate samples from glucose fermentation; “L1” and “L2” are the duplicate samples from lignin fermentation. All the fermentation was conducted by co-culture of three strains: R. jostii RHA1, R. jostii RHA1 vanA−, R. opacus PD630.
DOI: 10.6084/m9.figshare.7867304
title: Additional file 1: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S1. Sample information of human gut microbial metagenomic data and matched phageomes used in the RF training and evaluation dataset. (XLSX 43â KB) (XLSX 42 kb)
DOI: 10.6084/m9.figshare.7867304.v1
title: Additional file 1: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S1. Sample information of human gut microbial metagenomic data and matched phageomes used in the RF training and evaluation dataset. (XLSX 43â KB) (XLSX 42 kb)
DOI: 10.6084/m9.figshare.7867310
title: Additional file 2: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S2. Virus-specific POGs in uPOGs and POG 2012. (XLSX 39â KB) (XLSX 37 kb)
DOI: 10.6084/m9.figshare.13634457.v1
title: Additional file 10 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 10. Genome annotations of the 41 cluster-specific methylation sites
DOI: 10.6084/m9.figshare.13634460
title: Additional file 11 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 11. Functional enrichment analysis and the enriched 30 pathways
DOI: 10.6084/m9.figshare.13634463
title: Additional file 1 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 1. The clinical information and follow-up data of 504 patients
DOI: 10.6084/m9.figshare.13634466
title: Additional file 2 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 2. The clinical information of external training dataset
DOI: 10.6084/m9.figshare.13634466.v1
title: Additional file 2 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 2. The clinical information of external training dataset
DOI: 10.6084/m9.figshare.13634469
title: Additional file 3 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 3. The clinical information of external testing dataset
DOI: 10.6084/m9.figshare.13634469.v1
title: Additional file 3 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 3. The clinical information of external testing dataset
DOI: 10.6084/m9.figshare.13634472
title: Additional file 4 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 4. Univariate Cox regression analysis of the training dataset (1159)
DOI: 10.6084/m9.figshare.13634472.v1
title: Additional file 4 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 4. Univariate Cox regression analysis of the training dataset (1159)
DOI: 10.6084/m9.figshare.7867310.v1
title: Additional file 2: of Mining, analyzing, and integrating viral signals from metagenomic data

description: Table S2. Virus-specific POGs in uPOGs and POG 2012. (XLSX 39â KB) (XLSX 37 kb)
DOI: 10.6084/m9.figshare.13634460.v1
title: Additional file 11 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 11. Functional enrichment analysis and the enriched 30 pathways
DOI: 10.6084/m9.figshare.13634463.v1
title: Additional file 1 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 1. The clinical information and follow-up data of 504 patients
DOI: 10.6084/m9.figshare.13634475
title: Additional file 5 of Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma

description: Additional file 5. Multivariate Cox regression analysis of the 965 methylation sites (965)