cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12154764.v1
title: Impact of objective nutritional indexes on 1-year mortality after transcatheter aortic valve implantation: a prospective observational cohort study

description: The prognostic value of objective nutritional indexes has been demonstrated in many diseases. This study evaluated the prognostic value of these indexes in patients who underwent transcatheter aortic valve replacement (TAVI). Totally, 119 consecutive patients who underwent TAVI between January 2016 and December 2018 were evaluated. All patients were followed-up for one year. Objective nutritional index (geriatric nutritional risk index [GNRI], prognostic nutritional index [PNI]) and controlling nutritional status [CONUT]) scores were calculated before TAVI. Mean age of the study population was 77.1 ± 7.8 years (59.7% female). During one-year follow-up, 31 (26.1%) deaths were observed. In a Kaplan–Meier analysis, mortality rates were significantly increased in patients with lower GNRI and PNI and higher CONUT scores (50.01% vs. 4.4%; <i>p</i> p p p p The GNRI, PNI and CONUT scores were associated with 1-year all-cause mortality in patients who underwent TAVI. The predictive value of the GNRI score was significantly better than the PNI or CONUT scores. Assessment of the GNRI should be considered before TAVI.
DOI: 10.6084/m9.figshare.13214159
title: Improving engagement in managing reintroduction conflicts: learning from beaver reintroduction

description: Social factors hold implications for the success or failure of wildlife reintroductions. Potential conflict issues may prevent projects from proceeding or succeeding. The manner in which wildlife managers engage with affected people in conflict scenarios may prevent or contribute toward conflict escalation, so an understanding of how to improve engagement is required. We conducted interviews with individuals who reported conflicts with beavers (<i>Castor fiber</i>) within the case study of a reintroduction trial in England, called the ‘River Otter Beaver Trial’. Using a qualitative thematic analysis, we identified five themes to be considered when engaging with affected people in beaver reintroduction conflicts: (1) <i>Proactive Engagement or a Fast Response</i>; (2) <i>Appropriate Communication</i>; (3) <i>Shared Decision-Making</i>; (4) <i>Sense that Humans are Responsible for Conflicts with Reintroduced Species</i>; (5) <i>A Need for Certainty</i>. We conclude that engagement with affected individuals will likely be improved, with reduced conflict potential, where these themes are addressed.
DOI: 10.6084/m9.figshare.13214159.v1
title: Improving engagement in managing reintroduction conflicts: learning from beaver reintroduction

description: Social factors hold implications for the success or failure of wildlife reintroductions. Potential conflict issues may prevent projects from proceeding or succeeding. The manner in which wildlife managers engage with affected people in conflict scenarios may prevent or contribute toward conflict escalation, so an understanding of how to improve engagement is required. We conducted interviews with individuals who reported conflicts with beavers (<i>Castor fiber</i>) within the case study of a reintroduction trial in England, called the ‘River Otter Beaver Trial’. Using a qualitative thematic analysis, we identified five themes to be considered when engaging with affected people in beaver reintroduction conflicts: (1) <i>Proactive Engagement or a Fast Response</i>; (2) <i>Appropriate Communication</i>; (3) <i>Shared Decision-Making</i>; (4) <i>Sense that Humans are Responsible for Conflicts with Reintroduced Species</i>; (5) <i>A Need for Certainty</i>. We conclude that engagement with affected individuals will likely be improved, with reduced conflict potential, where these themes are addressed.
DOI: 10.6084/m9.figshare.14046851
title: Cost of human-elephant conflict and perceptions of compensation: evidence from Odisha, India

description: Odisha, an eastern Indian state, has reported an increasing number of human-elephant conflicts in recent years. Odisha's economic survey (2014–15) reveals that, up until January 2014, about 42,371.86-hectares of forest land had been destroyed for developmental activities. The loss of natural habitat has increased the frequency of conflict. The household survey conducted in nine villages within the Nilagiri forest range, captured various costs of conflict such as crop damage, human fatalities and injury, property damage, and livestock depredation. Findings suggested that crop-raiding was persistent and severe, which threatened food security and livelihoods. Multivariate logistic regression analysis identified factors influencing perceptions of the adequacy of compensation. Results show that respondents were less likely to say that compensation amounts were adequate if they had attended more than five years of schooling; if they had an annual family income greater than INR 13,500; and if the amount of compensation was more than INR 12,500.
DOI: 10.6084/m9.figshare.14046851.v1
title: Cost of human-elephant conflict and perceptions of compensation: evidence from Odisha, India

description: Odisha, an eastern Indian state, has reported an increasing number of human-elephant conflicts in recent years. Odisha's economic survey (2014–15) reveals that, up until January 2014, about 42,371.86-hectares of forest land had been destroyed for developmental activities. The loss of natural habitat has increased the frequency of conflict. The household survey conducted in nine villages within the Nilagiri forest range, captured various costs of conflict such as crop damage, human fatalities and injury, property damage, and livestock depredation. Findings suggested that crop-raiding was persistent and severe, which threatened food security and livelihoods. Multivariate logistic regression analysis identified factors influencing perceptions of the adequacy of compensation. Results show that respondents were less likely to say that compensation amounts were adequate if they had attended more than five years of schooling; if they had an annual family income greater than INR 13,500; and if the amount of compensation was more than INR 12,500.
DOI: 10.6084/m9.figshare.14847708
title: Combined inhibition of STAT and Notch signalling effectively suppresses tumourigenesis by inducing apoptosis and inhibiting proliferation, migration and invasion in glioblastoma cells

description: Glioblastoma multiforme (GBM) is the most aggressive primary brain cancer and this is due to cancer cells being apoptosis-resistant and having increased cell proliferation, migration, invasion, and angiogenesis properties. Previous studies have indicated both STAT and Notch pathways being important for initiation and progression in GBM. In this work, we first studied the effects of STAT inhibitors on Notch signalling using small molecule STAT inhibitors. It was observed that STAT inhibitors surprisingly activated Notch signalling by inducing NICD and Notch target genes in GBM cells. Thus, we aimed to combine STAT inhibitor treatment with a Notch pathway inhibitor and study effects on GBM tumourigenesis. STAT5 inhibitor (Pimozide) and STAT3 inhibitor (S3I-201) were individually used in combination with γ-secretase inhibitor (DAPT), an inhibitor of Notch signalling, in a panel of GBM cells for cell proliferation and epithelial plasticity changes. Compared with single-agent treatments, combinatorial treatments with the STAT and Notch inhibitors significantly increased apoptosis in the treated cells, impairing cell proliferation, migration, and invasion. These findings suggest that concurrent blocking of STAT and Notch signalling pathways could provide added therapeutic benefit for the treatment of glioblastoma.
DOI: 10.6084/m9.figshare.14847708.v1
title: Combined inhibition of STAT and Notch signalling effectively suppresses tumourigenesis by inducing apoptosis and inhibiting proliferation, migration and invasion in glioblastoma cells

description: Glioblastoma multiforme (GBM) is the most aggressive primary brain cancer and this is due to cancer cells being apoptosis-resistant and having increased cell proliferation, migration, invasion, and angiogenesis properties. Previous studies have indicated both STAT and Notch pathways being important for initiation and progression in GBM. In this work, we first studied the effects of STAT inhibitors on Notch signalling using small molecule STAT inhibitors. It was observed that STAT inhibitors surprisingly activated Notch signalling by inducing NICD and Notch target genes in GBM cells. Thus, we aimed to combine STAT inhibitor treatment with a Notch pathway inhibitor and study effects on GBM tumourigenesis. STAT5 inhibitor (Pimozide) and STAT3 inhibitor (S3I-201) were individually used in combination with γ-secretase inhibitor (DAPT), an inhibitor of Notch signalling, in a panel of GBM cells for cell proliferation and epithelial plasticity changes. Compared with single-agent treatments, combinatorial treatments with the STAT and Notch inhibitors significantly increased apoptosis in the treated cells, impairing cell proliferation, migration, and invasion. These findings suggest that concurrent blocking of STAT and Notch signalling pathways could provide added therapeutic benefit for the treatment of glioblastoma.
DOI: 10.25934/00003741.0
title: Available IPD datapackage for study 'A Prospective, Randomised, Double-blind, Double-dummy Trial to Compare the Efficacy of Micardis® (Telmisartan) (80 mg p.o. Once Daily) and Valsartan (160 mg p.o. Once Daily) in Patients With Mild-to-moderate Hypertension After Missing One Dose Using Ambulatory Blood Pressure Monitoring'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003741.1
title: IPD datapackage for study 'A Prospective, Randomised, Double-blind, Double-dummy Trial to Compare the Efficacy of Micardis® (Telmisartan) (80 mg p.o. Once Daily) and Valsartan (160 mg p.o. Once Daily) in Patients With Mild-to-moderate Hypertension After Missing One Dose Using Ambulatory Blood Pressure Monitoring' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.6073/pasta/0c3cfc91b89db7a6f4827a627bf7ea35
title: Ants in the New York Pine Barrens 2012-2013

description: Ants are ecologically important, environmentally sensitive, widespread, and abundant, yet ant assemblages of many habitats remain poorly understood. This is true of inland pine barrens in the northeastern United States. In the Northeast, such barrens support uncommon ant species and high species density for the region. Ants in inland barrens of New York State barely have been studied. To increase knowledge of these assemblages, I systematically collected ants from three NY inland barrens and investigated how hiking trails--a common man-made disturbance--may be impacting ant assemblages in these early-successional, disturbance-dependent ecosystems. My data strongly indicate uncommonly high densities of ant species in NY pine barrens, including the most northern known occurrences of two species, and show that hiking trails alter ant assemblage composition and species density.
DOI: 10.5281/zenodo.4792757
title: Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging

description: Source data of paper "Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging" published on Nature Methods.
DOI: 10.6084/m9.figshare.14040296
title: Figure 9: Species matches over flank lengths

description: Source data for Figure 9, and associated supplementary figure, for the elife submission: The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci.
DOI: 10.6084/m9.figshare.14040296.v1
title: Figure 10: Species matches over flank lengths

description: Source data for Figure 10, and associated supplementary figure, for the elife submission: The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci.
DOI: 10.25934/00003451.0
title: Available IPD datapackage for study 'A Prospective Randomised Open- Label Blinded-Endpoint (PROBE) Trial Comparing Telmisartan (MICARDIS®) (40-80-80mg QD) and Ramipril (2.5-5--10mg QD) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring. PRISMA = Prospective Randomised Investigation of the Safety and Efficacy of Micardis® vs Ramipril Using ABPM'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003451.1
title: IPD datapackage for study 'A Prospective Randomised Open- Label Blinded-Endpoint (PROBE) Trial Comparing Telmisartan (MICARDIS®) (40-80-80mg QD) and Ramipril (2.5-5--10mg QD) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring. PRISMA = Prospective Randomised Investigation of the Safety and Efficacy of Micardis® vs Ramipril Using ABPM' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.6084/m9.figshare.14458896
title: JEDI Billion Molecules against Covid-19: compounds synthesized

description: On May 4th 2020 a GrandChallenge entitled "Billion molecules against Covid-19" was launched by the Joint European Disruptive Initiative (JEDI). Teams from all over the world provided lists of compounds with suspected inhibitory properties versus specific SARS-CoV-2 and human host protein targets. Here we disclose 878 compounds, which were selected by the 20 top-ranked teams ('finalists'). Some finalists teams did not have compounds produced, because they were either unstable or synthetically unfeasible. The compounds were synthesized thanks to JEDI fundraising, and are in the process of being tested in biophysical assays, cell-based assays, etc. Purity data for each compound by LC-MS (liquid chromatography mass spectrometry) is provided. The data file contains SMILES information, molecular weight, purity, and solubility information (in DMSO dimethylsulfoxide). The compounds should be active against either one of the following SARS-CoV-2 protein targets: nsp3, nsp5, nucleocapsid (N), Spike (S), or RdRp (Nsp12), or against human host target TMPRSS2. Authors are listed in random order. Some co-authors are members of the Scientific Committee or organizing team of the GrandChallenge. All work has been performed with an open science mindset, and all data will be shared in the public domain. A publication is in preparation to disclose the experimental results. In version 1 of this data set it is likely that some co-author data is missing, which will be corrected in following versions. The data has been made public by the program manager of the GrandChallenge, Prof. Thomas M. Hermans. Author contributions are also available in spreadsheet format. Please contact covid19@jedi.foundation for more information, or check https://www.jedi.foundation/<br><br><br><em><strong>About JEDI </strong>- The Joint European Disruptive Initiative (JEDI) seeks to bring Europe in a leadership position in breakthrough technologies by launching Scientific and Technology GrandChallenges to push the frontiers of innovation. </em><em>It is the European advanced research projects agency (ARPA) with a radical method based on excellence, speed, high expectations, bold risk-taking & no geographical return </em><em>to solve major societal issues in environment, healthcare, digital, education, oceans & space. Driven by humanistic values, JEDI is a not-for-profit organization financed by foundations, governments, corporates and powered by the contribution of 4.100 technology and scientific leaders from academia, corporations and deeptech startups in 29 countries in Europe.</em><em><br></em><em>update 30/06/2021 17:32 CET: 12 additional co-authors added, and updated acknowledgement spreadsheet<br></em><br>
DOI: 10.25934/00003450.0
title: Available IPD datapackage for study 'A Prospective, Randomised, Open-Label, Blinded-Endpoint, Parallel Group, Multicentre, Forced-Titration, 14-Week Treatment Study Comparing MICARDIS® (Telmisartan 40-80-80 mg, QD) and ALTACE® (Ramipril 2.5-5-10 mg, QD) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003450.1
title: IPD datapackage for study 'A Prospective, Randomised, Open-Label, Blinded-Endpoint, Parallel Group, Multicentre, Forced-Titration, 14-Week Treatment Study Comparing MICARDIS® (Telmisartan 40-80-80 mg, QD) and ALTACE® (Ramipril 2.5-5-10 mg, QD) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.6073/pasta/b84617940e35f87cd746ce58305e33d2
title: Water Chemistry and Well Levels at Upper Bigelow Brook, Harvard Forest 2009-2010

description: This dataset is the result of a full year of high-resolution monitoring of hydrologic event-driven export of stream dissolved organic matter from the Upper Pipe site on Bigelow Brook at Harvard Forest. In situ measurements of fluorescent dissolved organic matter (FDOM) and conductivity were collected from October of 2009 to December of 2010. Grab samples of water were collected during hydrological events and analyzed using standard methods for dissolved organic matter, nitrate, ammonium, and dissolved organic nitrogen. Water level measurements in wells at this study site were initiated in May of 2010.
DOI: 10.25934/00003404.0
title: Available IPD datapackage for study 'A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Investigate the Efficacy of Telmisartan 80 mg Versus Valsartan 160 mg in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy VIVALDI-Study'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003404.1
title: IPD datapackage for study 'A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Investigate the Efficacy of Telmisartan 80 mg Versus Valsartan 160 mg in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy VIVALDI-Study' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003419.0
title: Available IPD datapackage for study 'A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare MICARDIS® (Telmisartan) 80 mg Versus COZAAR® (Losartan) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy (AMADEO Study)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.
DOI: 10.25934/00003419.1
title: IPD datapackage for study 'A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare MICARDIS® (Telmisartan) 80 mg Versus COZAAR® (Losartan) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy (AMADEO Study)' and research request: 'Heterogeneity in relative treatment efficacy by age, sex, socioeconomic status and comorbidity (McAllister)'

description: Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through the creation and implementation of a sustainable global data-sharing enterprise. The Vivli platform includes an independent data repository, in-depth search engine and a cloud-based, secure analytics platform.