cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23257163
title: Integrating analysis of proteome profile and drug screening identifies therapeutic potential of MET pathway for the treatment of malignant peripheral nerve sheath tumor

description: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with a poor prognosis that requires novel therapeutic agents. Proteome information is useful for identifying new therapeutic candidates because it directly reflects the biological phenotype. Additionally, in vitro drug screening is an effective tool to identify candidate drugs for common cancers. Hence, we attempted to identify novel therapeutic candidates for MPNST by integrating proteomic analysis and drug screening. We performed comprehensive proteomic analysis on 23 MPNST tumor samples using liquid chromatography – tandem mass spectrometry to identify therapeutic targets. We also conducted drug screening of six MPNST cell lines using 214 drugs. Proteomic analysis revealed that the MET and IGF pathways were significantly enriched in the local recurrence/distant metastasis group of MPNST, whereas drug screening revealed that 24 drugs showed remarkable antitumor effects on the MPNST cell lines. By integrating the results of these two approaches, MET inhibitors, crizotinib and foretinib, were identified as novel therapeutic candidates for the treatment of MPNST. We successfully identified novel therapeutic candidates for the treatment of MPNST, namely crizotinib and foretinib, which target the MET pathway. We hope that these candidate drugs will contribute to the treatment of MPNST.
DOI: 10.6084/m9.figshare.23560335
title: Survey of the abundance and distribution of cetaceans off Costa Rica's Pacific coast

description: <strong>Description:</strong> The data presented here were obtained from a survey investigating the abundance and distribution of cetaceans off Costa Rica's Pacific coast in January 2022. Surveys were carried out in accordance with the survey protocol set out by the NGO <em>ORCA</em>. Briefly, surveys involved a port and starboard observer at all times. The observers scanned an area from 90<sup>o</sup> on their own side to 10<sup>o</sup> on the opposite side, totalling an area of 100<sup>o</sup> each. Scanning took place visually and using binoculars. Regular rotations between members of the survey team took place to prevent fatigue. Effort, weather, GPS and sightings data were recorded throughout the duration of the survey, meaning both presence and absence data were recorded. The ship did not deviate its course in response to sightings. In total, over 32 hours of surveys were conducted over a period of 10 days, covering the majority of the Pacific Coast of Costa Rica. A total of 206 individuals from 4 different species were sighted during the survey. Surveys were conducted from the tall ship <em>Pelican of London</em> (owned by <em>Seas Your Future</em>) by experienced surveyors. <strong>Dataset:</strong> The dataste consists of 3 .csv files and 2 .kmz files. The 'Observations_Effort_Sightings' .csv file contains all effort, weather and sighting data whilst on-effort. The 'Incidental_Sightings' .csv file contains a list of incidental sightings made whilst off-effort. The 'Key' .csv files describes the abbreviations used in the other two .csv files. The .kmz files contain tracks of the ship's route during the duration of the survey. The 'Track_Points' .kmz file contains the points along the ship's track, and the 'Track_Smoothed' .kmz file contains a smoothed version of the track. Please note that the track includes time spent off-effort. Please contact the authors if you have any questions about the dataset. <strong>Acknowledgements:</strong> Thanks goes to <em>Seas Your Future </em>and<em> Brasenose College, University of Oxford </em>for funding this work. We would also like to acknowledge the crew of the <em>Pelican of London</em> for their support throughout the survey, particularly the Captain Ben Wheatley and First Mate Tamsin Lambert. We would further like to thank Dr Charlotte Braungardt for her assistance with planning and Hannah Gibbs, Megan Derrick, Sari Ponnet, Jeremy DeMoss, Yasmin Deter, and Emily Murphy Gray for their help with data collection.
DOI: 10.17037/data.00003513
title: Study data for “Identifying underweight in infants and children using growth charts, lookup tables and a novel “MAMI” slide chart: a cross-over diagnostic and acceptability study”

description: Malnutrition is a leading cause of preventable deaths in infants and children. However, to benefit from treatment and prevention programmes, malnourished children must first be identified. The MAMI chart project developed and tested a novel, low-cost weight-for-age slide chart (the "MAMI" chart) and compared it against traditional growth charts and look-up tables. This collection contains questionnaires, quantitative data, and summary results associated with the cross-over diagnostic study.
description: For this project, we developed and tested a novel, low-cost weight-for-age slide chart (the "MAMI" chart, named after a wider but very closely related programme of work on "Management of small, nutritionally At-risk Infants and their Mothers". We subsequently conducted a cross-over diagnostic study that compared the new “MAMI” slide-chart against two traditional methods, growth charts and look-up tables. Participants were health and public health professionals working or studying in the UK. Each acted as their own control, using all three methods but in random order. Under timed conditions, they evaluated hypothetical scenarios, arranged in a random sequence. Each tool's diagnostic accuracy and response rate were compared. User preferences were also recorded. We developed 25 hypothetical clinical scenarios which presented a child’s sex, weight and age. The test task was to correctly classify as many of these as possible into normal weight, moderately underweight or severely underweight. Numbers in each category were roughly balanced. Eight of the 25 scenarios had the WAZ score exactly at -2 or -3 z score (borderline scenarios) to make them more challenging. The answer key was developed for the questionnaires and were cross-checked for any errors, prior to the evaluation. Additionally, one-third of the scenarios were intentionally kept at borderline z-scores. Two questionnaires were used: [1] a general questionnaire containing the 25 scenarios which asked participants to select what they determined to be the correct anthropometric classification in each case (normal, moderately underweight, severely underweight). Basic participant demographics were also collected by this questionnaire. [2] an acceptability questionnaire which asked for feedback on the three different assessment tools/methods. Questionnaires were administered electronically via Microsoft forms (Office 365, Microsoft, USA).
DOI: 10.5281/zenodo.7974096
title: Mammalian animal & human retinal organ culture as pre-clinical model to evaluate oxidative stress and antioxidant intraocular therapeutics

description: Oxidative stress (OS) is involved in the pathogenesis of retinal neurodegenerative diseases like age-related macular degeneration (AMD) and diabetic retinopathy (DR) and an important target of therapeutic treatments. New therapeutics are tested in vivo despite limits in transferability and ethical concerns. Retina cultures using human tissue can deliver critical information and significantly reduce the number of animal experiments along with increased transferability. We cultured up to 32 retina samples derived from one eye, analyzed models’ quality, induced OS, and tested efficiency of antioxidative therapeutics. Bovine, porcine, rat, and human retinae were cultured in different experimental settings for 3-14 d. OS was induced by high-glucose or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and treated by Scutellarin, pigment epithelium-derived factor (PEDF), and/or granulocyte macrophage-colony stimulating factor (GM-CSF). Tissue morphology, cell viability, inflammation, and glutathione level were determined. Retina samples showed only moderate necrosis (23.83±5.05 increased to 27.00±1.66 AU PI-staining over 14 d) after 14 days in culture. OS was successfully induced (reduced ATP content of 288.3±59.9 vs. 435.7±166.8 nM ATP in controls); antioxidants reduced OS-induced apoptosis (from 124.20±51.09 to 60.80±319.66 cells/image after Scutellarin-treatment). Enhanced mammalian animal and human retina cultures allow reliable, highly transferable research on OS-triggered age-related diseases and pre-clinical testing during drug development.
DOI: 10.5281/zenodo.7974095
title: Mammalian animal & human retinal organ culture as pre-clinical model to evaluate oxidative stress and antioxidant intraocular therapeutics

description: Oxidative stress (OS) is involved in the pathogenesis of retinal neurodegenerative diseases like age-related macular degeneration (AMD) and diabetic retinopathy (DR) and an important target of therapeutic treatments. New therapeutics are tested in vivo despite limits in transferability and ethical concerns. Retina cultures using human tissue can deliver critical information and significantly reduce the number of animal experiments along with increased transferability. We cultured up to 32 retina samples derived from one eye, analyzed models’ quality, induced OS, and tested efficiency of antioxidative therapeutics. Bovine, porcine, rat, and human retinae were cultured in different experimental settings for 3-14 d. OS was induced by high-glucose or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and treated by Scutellarin, pigment epithelium-derived factor (PEDF), and/or granulocyte macrophage-colony stimulating factor (GM-CSF). Tissue morphology, cell viability, inflammation, and glutathione level were determined. Retina samples showed only moderate necrosis (23.83±5.05 increased to 27.00±1.66 AU PI-staining over 14 d) after 14 days in culture. OS was successfully induced (reduced ATP content of 288.3±59.9 vs. 435.7±166.8 nM ATP in controls); antioxidants reduced OS-induced apoptosis (from 124.20±51.09 to 60.80±319.66 cells/image after Scutellarin-treatment). Enhanced mammalian animal and human retina cultures allow reliable, highly transferable research on OS-triggered age-related diseases and pre-clinical testing during drug development.
DOI: 10.25345/c5jq0t52v
title: MassIVE MSV000092305 - Samples_Paula_230629_Remeasurement
title: Samples remeasured (Paula, AK Mordhorst), 29/06/2023
DOI: 10.18712/nsd-nsd2202-2-v2
title: InfraRisk Module B - Calculation of Avalanche and Rockfall Prone Roads and Railways, 2010

description: Impacts of extreme weather events on infrastructure in Norway (InfraRisk)
InfraRisk Module B - Calculation of avalanche and rockfall prone roads and railways

The research project "Impacts of extreme weather events on infrastructure in Norway (InfraRisk)" was completed in the period 2010 to 2013 as part of NORKLIMA program (2004-2013), and was a collaboration between researchers from the Norwegian Geotechnical Institute, Norwegian Meteorological Institute, CICERO Centre for Climate Research and Transport Economics. InfraRisk was a so-called competence project with user involvement from NPRA, National Rail Administration and the National Training Centre for Civil Protection and Emergency Planning (NUSB). The project has studied changes in extreme weather and the effects extreme weather events have on infrastructure related to the transport sector in Norway. The interdisciplinary collaboration has been the interface between the physical processes, vulnerability and risk.
DOI: 10.6084/m9.figshare.23599818
title: Mantle-to-crust metal transfer by nanomelts - Schettino 2023

description: Data sets include crystallographic measurements of lattice parameters in nanoparticles by high-resolution transmission electron microscopy, and concentrations of chalcophile elements in magmatic sulfides by laser ablation-inductively coupled plasma-mass spectrometry.
DOI: 10.15480/336.2393
title: Datasets for the microstructure of nanoscale metal network structures and for its evolution during coarsening

description: The description of the data format as well as the analysis processes for data have been summarized in the file "Description_of_data.pdf" (the last file in this data list). The datasets in this work are files containing atom position coordinates of volume elements approximating nanoporous gold made by dealloying and annealing. The material is represented in an as-prepared state and in various stages of coarsening, as described in Phys. Rev. Mater, 3 (2019) 076001. Realistic initial structures of different solid fractions have been constructed by the leveled-wave algorithm, approximating mixtures at the end of early-stage spinodal decomposition. The microstructural evolution during coarsening by surface diffusion was approximated by on-lattice kinetic Monte-Carlo simulation. The data sets refer to solid fractions from 0.22 to 0.50, providing for different initial connectivity of the bicontinuous structures. Coarsening at two temperatures, 900 K and 1800 K, explores two different degrees of surface energy anisotropy – more faceted at 900 K and more rough at 1800 K. Each structure takes the form of a face-centred cubic lattice with approximately 32 million sites. A site can be occupied by either void or atom. 3D periodic boundary conditions are satisfied. Tables list each structure’s properties, and specifically the specific surface area, two different measures for the ligament size, the net topologic genus as well as the scaled genus. The atom coordinate files may serve as the basis for geometry analysis and for atomistic as well as finite element simulation studies of nanoporous as well as spinodally decomposed materials.
DOI: 10.5519/qd.8nhdj8my
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (822557 records)
DOI: 10.17037/data.00003535
title: Identifying underweight in infants and children: the novel “MAMI” slide chart (evaluating performance against traditional diagnostic methods, lookup tables and growth charts)
DOI: 10.5281/zenodo.8087777
title: On the Determinants of Real Estate Returns

description: Data on GDP growth, inflation, and remittances are collected from the Pakistan Economic Survey.[1] The growth rate of the consumer price index (CPI) has been used to measure inflation. The database of the State Bank of Pakistan has been used to collect data on interest rates. We used commercial banks’ lending rates to proxy the interest rate in the economy. While population density at the Pakistan level was extracted from the Pakistan Economic Survey. However, data on the city-wise population density was not available, therefore, we computed it by extrapolating the city-wise density figure for 2017 on the basis of city-wise population growth rates.
DOI: 10.5281/zenodo.8087778
title: On the Determinants of Real Estate Returns

description: Data on GDP growth, inflation, and remittances are collected from the Pakistan Economic Survey.[1] The growth rate of the consumer price index (CPI) has been used to measure inflation. The database of the State Bank of Pakistan has been used to collect data on interest rates. We used commercial banks’ lending rates to proxy the interest rate in the economy. While population density at the Pakistan level was extracted from the Pakistan Economic Survey. However, data on the city-wise population density was not available, therefore, we computed it by extrapolating the city-wise density figure for 2017 on the basis of city-wise population growth rates.
DOI: 10.48366/r599725
title: A Comparison of Studies on Young Adults' Travel Behavior

description: Comparison of three studies that examine the travel behavior of young adults and its relationship with residential location choice and attitudes.
DOI: 10.20387/bonares-wx17-m527
title: Optical contact angle of air-dry soil samples

description: The optical contact angle of the samples was measured by attaching a one-grain layer of the air-dry soil sample to a piece op tape and release a drop of water onto it. The contact angle was determined from the image of the water drop on the soil (see supplementary pictures). The soil samples were taken from cover crop root channels and bulk soil six weeks after the cover crops had been terminated with a herbicide.

Research domain: Soil Sciences

Research question: How hydrophobic is the material in cover crop root channels.
DOI: 10.25345/c5dz03b8g
title: MassIVE MSV000092306 - 230515 All mock dump samples GNPS-MassIVE
title: 230515 All mock dump samples GNPS-MassIVE 230515 All mock dump samples GNPS-MassIVE 230515 All mock dump samples GNPS-MassIVE
DOI: 10.5281/zenodo.8094820
title: Data for the paper "Policy Sandboxing: Empathy As An Enabler Towards Inclusive Policy-Making"

description: Data collected and used for the analysis for the paper "Policy Sandboxing: Empathy As An Enabler Towards Inclusive Policy-Making". Each value - beside the demographics and the opinions - corresponds to a value of a 5-level likert scale. For a more detailed explanation please refer to the paper.
DOI: 10.5281/zenodo.8094812
title: Data for the paper "Policy Sandboxing: Empathy As An Enabler Towards Inclusive Policy-Making"

description: Data collected and used for the analysis for the paper "Policy Sandboxing: Empathy As An Enabler Towards Inclusive Policy-Making". Each value - beside the demographics and the opinions - corresponds to a value of a 5-level likert scale. For a more detailed explanation please refer to the paper.
DOI: 10.5281/zenodo.6477750
title: Microclimate dataset of the SAFE project landscape

description: Daily projections of mean and maximum temperature and vapour pressure deficit (VPD) across the SAFE landscape in Borneo, Malaysia. Data was used to model the number of yearly life-cycle completions (LCC/year) of the disease vector Aedes Albopictus in order to study the impact of deforestation for oil palm plantation on microclimate-driven vector suitability. Dataset contains stacked raster files with a 50-meter grid cell resolution (n = 145,214 grid cells, equivalent to approximately 363 km2). Microclimate data were projected using LiDAR-derived DEM, CHM and point cloud-derived metrics, combined with microclimatic data from dataloggers, as inputs (see associated doi for more information: Jucker et al (2018)). <strong>Date range: </strong>2013-05-01 to 2015-03-01<br> <strong>Latitudinal extent: </strong>4.5000 to 5.0700<br> <strong>Longitudinal extent: </strong>116.7500 to 117.8200
DOI: 10.5281/zenodo.6477751
title: Daily Maximum Temperature Projections

description: <b>Description: </b>Maximum Daily temperature projection for the SAFE project landscape<b>Project: </b>This dataset was collected as part of the following SAFE research project: <b>Assessing the Impact of Microclimate During Development on the Physiological Thermal Tolerance of Lowland Malaysian Dung Beetles </b><b>Funding: </b>These data were collected as part of research funded by: NERC (hmtf programme, NE/K016377/1 )This dataset is released under the CC-BY 4.0 licence, requiring that you cite the dataset in any outputs, but has the additional condition that you acknowledge the contribution of these funders in any outputs.<b>XML metadata: </b>GEMINI compliant metadata for this dataset is available here<b>Files: </b>This dataset consists of 2 files: safe_submission_tmax.xlsx, T_max_raster.tif<b>safe_submission_tmax.xlsx</b>This file contains dataset metadata and 1 data tables:<b>Data</b> (described in worksheet Data)Description: EmptyNumber of fields: 0Number of data rows: 1020Fields: <b>T_max_raster.tif</b>Description: 50-m resolution projection of maximum daily temperature across the SAFE landscape (n = 145,214 grid cells, equivalent to approximately 363 km2) using DEM, CHM and point cloud-derived metrics, combined with microclimatic data from dataloggers, as inputs. (See associated doi for details).<b>Date range: </b>2013-05-01 to 2015-03-01<b>Latitudinal extent: </b>4.5000 to 5.0700<b>Longitudinal extent: </b>116.7500 to 117.8200
DOI: 10.5281/zenodo.7893600
title: Microclimate dataset of the SAFE project landscape

description: Daily projections of mean and maximum temperature and vapour pressure deficit (VPD) across the SAFE landscape in Borneo, Malaysia. Data was used to model the number of yearly life-cycle completions (LCC/year) of the disease vector Aedes Albopictus in order to study the impact of deforestation for oil palm plantation on microclimate-driven vector suitability. Dataset contains stacked raster files with a 50-meter grid cell resolution (n = 145,214 grid cells, equivalent to approximately 363 km2). Microclimate data were projected using LiDAR-derived DEM, CHM and point cloud-derived metrics, combined with microclimatic data from dataloggers, as inputs (see associated doi for more information: Jucker et al (2018)). <strong>Date range: </strong>2013-05-01 to 2015-03-01<br> <strong>Latitudinal extent: </strong>4.5000 to 5.0700<br> <strong>Longitudinal extent: </strong>116.7500 to 117.8200
DOI: 10.25919/vpac-0q40
title: Parkes observations for project P1183 semester 2023APRS_10

description: A new energetic repeating FRB 20220529 can be observed by both FAST and Parkes telescopes and the simultaneous observing time is up to one hour. We have observed this source using Parkes UWL green time and in total 21 bursts have been detected. Two bursts of them have the corresponding simultaneous FAST observations. Only one burst has 4-pol datasets and is bright enough to analyse the polarization properties. Therefore, we propose to continue the monitoring of the source of FRB 20220529 using the Parkes UWL with high-time resolution and 4-pol observation. The new proposed observation aims to: (1)detect more bursts by Parkes UWL with full polarization information; (2) detect more bursts by Parkes UWL with corresponding simultaneous FAST observations; (3) study the radiation spectrum by more bursts detected in simultaneous observations of Parkes and FAST; (4) study the burst microstructure using high time resolution datasets, and (5) study the frequency ranges changes of the repeating bursts.
DOI: 10.34740/kaggle/dsv/6052118
title: UK Pickup Brands Dataset