cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7916/d86973fq
title:  Supplemental Data: PLA2G6 Mutations Related to Distinct Phenotypes: A New Case with Early-onset Parkinsonism

description: Background: PLA2G6-associated neurodegeneration (PLAN) is a recessive neurodegenerative disorder characterized by three distinct phenotypes: infantile neuroaxonal dystrophy (INAD), atypical neuroaxonal dystrophy (atypical NAD), and PLA2G6-related dystonia–parkinsonism. Methods: A consanguineous index case from Turkey was diagnosed with early-onset Parkinsonism at the Istanbul Faculty of Medicine. She and her unaffected brother were subjected to whole-genome sequencing. Results: In this report, we describe a 33-year-old index case with parental consanguinity and early-onset Parkinsonism. Whole-genome sequencing of this individual revealed that a homozygous p.R747W mutation in PLA2G6 segregates with the disease in this family Discussion: This result supports the importance of prioritizing this gene in mutational analysis of autosomal recessive Parkinsonism, and confirms the clinical heterogeneity of PLAN.
DOI: 10.7916/d8bg2pcx
title:  Supplemental Data: Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women

description: The structural integrity of the cervix in pregnancy is necessary for carrying a pregnancy until term, and the organization of human cervical tissue collagen likely plays an important role in the tissue’s structural function. Collagen fibers in the cervical extracellular matrix exhibit preferential directionality, and this collagen network ultrastructure is hypothesized to reorient and remodel during cervical softening and dilation at time of parturition. Within the cervix, the upper half is substantially loaded during pregnancy and is where the premature funneling starts to happen. To characterize the cervical collagen ultrastructure for the upper half of the human cervix, we imaged whole axial tissue slices from non-pregnant and pregnant women undergoing hysterectomy or cesarean hysterectomy respectively using optical coherence tomography (OCT) and implemented a pixel-wise fiber orientation tracking method to measure the distribution of fiber orientation. The collagen fiber orientation maps show that there are two radial zones and the preferential fiber direction is circumferential in a dominant outer radial zone. The OCT data also reveal that there are two anatomic regions with distinct fiber orientation and dispersion properties. These regions are labeled: Region 1 - the posterior and anterior quadrants in the outer radial zone and Region 2 - the left and right quadrants in the outer radial zone and all quadrants in the inner radial zone. When comparing samples from nulliparous vs multiparous women, no differences in these fiber properties were noted. Pregnant tissue samples exhibit an overall higher fiber dispersion and more heterogeneous fiber properties within the sample than non-pregnant tissue. Collectively, these OCT data suggest that collagen fiber dispersion and directionality may play a role in cervical remodeling during pregnancy, where distinct remodeling properties exist according to anatomical quadrant.
DOI: 10.7916/d8n879tt
title:  Supplemental Data: Using Portable Transducers to Measure Tremor Severity

description: Background: Portable motion transducers, suitable for measuring tremor, are now available at a reasonable cost. The use of these transducers requires knowledge of their limitations and data analysis. The purpose of this review is to provide a practical overview and example software for using portable motion transducers in the quantification of tremor. Methods: Medline was searched via PubMed.gov in December 2015 using the Boolean expression ‘‘tremor AND (accelerometer OR accelerometry OR gyroscope OR inertial measurement unit OR digitizing tablet OR transducer).’’ Abstracts of 419 papers dating back to 1964 were reviewed for relevant portable transducers and methods of tremor analysis, and 105 papers written in English were reviewed in detail. Results: Accelerometers, gyroscopes, and digitizing tablets are used most commonly, but few are sold for the purpose of measuring tremor. Consequently, most software for tremor analysis is developed by the user. Wearable transducers are capable of recording tremor continuously, in the absence of a clinician. Tremor amplitude, frequency, and occurrence (percentage of time with tremor) can be computed. Tremor amplitude and occurrence correlate strongly with clinical ratings of tremor severity. Discussion: Transducers provide measurements of tremor amplitude that are objective, precise, and valid, but the precision and accuracy of transducers are mitigated by natural variability in tremor amplitude. This variability is so great that the minimum detectable change in amplitude, exceeding random variability, is comparable for scales and transducers. Research is needed to determine the feasibility of detecting smaller change using averaged data from continuous long-term recordings with wearable transducers.
DOI: 10.7916/d8qn6czg
title:  Supplemental Data: TBC1D24 Mutations in a Sibship with Multifocal Polymyoclonus

description: Advances in molecular genetic technologies have improved our understanding of genetic causes of rare neurological disorders with features of myoclonus. Case Report: A family with two affected siblings, presenting with multifocal polymyoclonus and neurodevelopmental delay, was recruited for whole-exome sequencing following unyielding diagnostic neurometabolic investigations. Compound heterozygous mutations in TBC1D24, a gene previously associated with various epilepsy phenotypes and hearing loss, were identified in both siblings. The mutations included a missense change c.457G.A (p.Glu157Lys), and a novel frameshift mutation c.545del (p.Thr182Serfs*6). Discussion: We propose that TBC1D24-related diseases should be in the differential diagnosis for children with polymyoclonus.
DOI: 10.7916/d8wh3118
title:  Supplemental Images: Axial Sensory Tricks in Chorea–Acanthocytosis: Insights into Phenomenology

description: Background: Trunk flexion and axial extension are characteristic symptoms of chorea–acanthocytosis (ChAc). Phenomenology Shown: A 41-year-old male with ChAc (confirmed by VPS13A mutations) reported that his involuntary axial movements were significantly ameliorated by either folding his arms over his chest or putting his hands behind his head. Educational Value: These apparent “sensory tricks” suggest a dystonic pathophysiology, and also merit further study to analyze their potential for symptom control in ChAc.
DOI: 10.7916/d8-0pha-mw03
title:  Supplemental Video S2

description: Time-lapse video showing a mouse peripheral airway contracting in response to ACh, relaxing upon TLCA addition and re-contracting after TLCA removal in the continuous presence of ACh. This video illustrates the representative experiment shown in Fig. 1E.
DOI: 10.7916/d8-4wpn-wr76
title:  Supplemental Video S1

description: Time-lapse video showing a human peripheral airway contracting in response to ACh and relaxing upon TLCA addition. Labels indicate time of ACh and TLCA perfusion. Experimental time is indicated in the bottom left corner. This video illustrates the representative experiment shown in Fig. 1B.
DOI: 10.7916/d8tx3f8w
title:  Supplementary Information: Tornado outbreak variability follows Taylor’s power law of fluctuation scaling and increases dramatically with severity

description: Tornadoes cause loss of life and damage to property each year in the United States and around the world. The largest impacts come from ‘outbreaks’ consisting of multiple tornadoes closely spaced in time. Here we find an upward trend in the annual mean number of tornadoes per US tornado outbreak for the period 1954–2014. Moreover, the variance of this quantity is increasing more than four times as fast as the mean. The mean and variance of the number of tornadoes per outbreak vary according to Taylor’s power law of fluctuation scaling (TL), with parameters that are consistent with multiplicative growth. Tornado-related atmospheric proxies show similar power-law scaling and multiplicative growth. Path-length-integrated tornado outbreak intensity also follows TL, but with parameters consistent with sampling variability. The observed TL power-law scaling of outbreak severity means that extreme outbreaks are more frequent than would be expected if mean and variance were independent or linearly related.
DOI: 10.7916/d8v69qwm
title:  Supplementary Materials of "Neonatal brain structure and connectivity in infants exposed to antidepressants during pregnancy"

description: Analysis codes used in "Neonatal brain structure and connectivity in infants exposed to antidepressants during pregnancy"
DOI: 10.7916/d8-gy5t-ws30
title:  T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces

description: Cells have the remarkable ability to sense the mechanical stiffness of their surroundings. This has been studied extensively in the context of cells interacting with planar surfaces, a conceptually elegant model that also has application in biomaterial design. However, physiological interfaces are spatially complex, exhibiting topographical features that are described over multiple scales. This report explores mechanosensing of microstructured elastomer surfaces by CD4+ T cells, key mediators of the adaptive immune response. We show that T cells form complex interactions with elastomer micropillar arrays, extending processes into spaces between structures and forming local areas of contraction and expansion dictated by the layout of microtubules within this interface. Conversely, cytoskeletal reorganization and intracellular signaling are sensitive to the pillar dimensions and flexibility. Unexpectedly, these measures show different responses to substrate rigidity, suggesting competing processes in overall T cell mechanosensing. The results of this study demonstrate that T cells sense the local rigidity of their environment, leading to strategies for biomaterial design.
DOI: 10.7916/d8-n06m-e620
title:  Supporting Information: Membrane-less and Non-Evaporative Desalination of Hypersaline Brines by Temperature Swing Solvent Extraction

description: Hypersaline brines are of growing environmental importance but are technologically under-served by today’s desalination methods. Temperature swing solvent extraction (TSSE) is a radically different desalination technology that is membrane-less and not based on evaporative phase change. TSSE utilizes low-temperature heat and a low-polarity solvent with temperature-dependent water solubility for the selective extraction of water over salt from saline feeds. This study demonstrates TSSE desalination of high-salinity brines simulated by NaCl solutions with three amine solvents: diisopropylamine (DIPA), N-ethylcyclohexylamine (ECHA), and N,N-dimethylcyclohexylamine (DMCHA). We show that TSSE can desalinate brines with salinities as high as ≈234000 ppm total dissolved solids (i.e., 4.0 M NaCl) and achieve salt removals up to 98.4%. Among the solvents, DIPA exhibited the highest water extraction efficiency whereas ECHA and DMCHA produced water with the lowest salt content and solvent residue content, respectively. Lastly, a high water recovery of &gt;50% was demonstrated for TSSE desalination of 1.5 M NaCl brine using DIPA in semibatch experiments with multiple extraction cycles. This study underscores the unique capabilities of TSSE for the desalination of hypersaline brines.
DOI: 10.7916/d84q7rzt
title:  Technical Appendix to Is expanding Medicare coverage cost-effective?

description: Technical Appendix to Is expanding Medicare coverage cost-effective?
DOI: 10.7916/d8dn44qw
title:  Tensile Equilibrium Mechanical Data and Material Properties of Nonpregnant and Pregnant Mouse Cervical Tissue

description: These files contain mechanical data and best fit material parameters from a study evaluating the tensile equilibrium properties of mouse cervices in normal gestation. The exp_data folder contains a .csv file corresponding to each tested sample. Each file includes the experimental tensile equilibrium data. The name of the file indicates the sample ID, which includes the the gestation day (NP = nonpregnant, d6 = gestation day 6, d12 = gestation day 12, d15 = gestation day 15, d18 = gestation day 18) and the sample number identifier. For example, “NP_1_data” corresponds to the experimental data for nonpregnant sample #1 and “d6_3_dat” corresponds to the experimental data for gestation day 6 sample #3. In these files, the columns correspond to: the grip-to-grip displacement [mm] , cervical opening [mm], equilibrium force [N], average width [mm], standard deviation of the width [mm], average length [mm], standard deviation of the length [mm], average height [mm], standard deviation of the height [mm], average of the top thickness [mm], standard deviation of the top thickness [mm], average bottom thickness [mm], and the standard deviation of the bottom thickness [mm] of the cervical sample. The cervical opening, average and standard deviation of the width, length, height, and thicknesses are determined via camera images. The grip-to-grip displacement and equilibrium force are data from the universal testing machine. The IFEA_results.csv file lists the inverse finite element analysis (IFEA) results for each sample. The first column shows the sample identifier, which corresponds to each sample from the exp_data file with the same file name. Columns 2-5 (width_ref [mm], length_ref [mm], height_ref [mm], thickness_ref [mm]) indicates the reference geometry of the cylinder. In this study, the cervix was modeled as a thick-walled cylinder with an elliptical cross-section. Columns 6-11 indicate the best-fit material parameters from the IFEA analysis. The models were run in FEBio v.2.2.6. The cervix was modeled as a mixture of three materials: Donnan Equilibrium, Neo-Hookean, and an isotropic continuous fiber distribution with power-law fibers. Columns 6 and 7 correspond to the Donnan Equilibrium parameters of fluid volume fraction (phiw0) and reference fixed charge density (cF0 [mEq/L]). Columns 8 and 9 correspond to the Neo-Hookean parameters of Young’s modulus (E [MPa]) and poisson’s ratio (v). Columns 10 and 11 correspond to the continuous fiber distribution material parameters, stiffening parameter (beta) and fiber stiffness (ksi [MPa]). Columns 12 and 13 represent the error between the model fits to the swelling data presented as % error (column 12) and the goodness of fit (r2 value) of the model to the cervical opening vs. F_eq data (column 13). Columns 14-17 shows the r2 values of the model predictions to the experimental data for cervical opening vs. width (column 14), vs. length (column 15), vs. height (column 16), and vs. thickness (column 17).
DOI: 10.7916/d8w95j4h
title:  The Adolescent Concept of Intelligence and Gardner's Theory of Multiple Intelligences: Appendix

description: Survey instrument used for the thesis project described in "The Adolescent Concept of Intelligence and Gardner's Theory of Multiple Intelligences," which is available at http://hdl.handle.net/10022/AC:P:10370.
DOI: 10.7916/d8rx9bd3
title:  The Geological Record of Ocean Acidification: Supporting Online Material

description: Ocean acidification may have severe consequences for marine ecosystems; however, assessing its future impact is difficult because laboratory experiments and field observations are limited by their reduced ecologic complexity and sample period, respectively. In contrast, the geological record contains long-term evidence for a variety of global environmental perturbations, including ocean acidification plus their associated biotic responses. We review events exhibiting evidence for elevated atmospheric CO2, global warming, and ocean acidification over the past ~300 million years of Earth's history, some with contemporaneous extinction or evolutionary turnover among marine calcifiers. Although similarities exist, no past event perfectly parallels future projections in terms of disrupting the balance of ocean carbonate chemistry—a consequence of the unprecedented rapidity of CO2 release currently taking place.
DOI: 10.7916/d8hd7tzz
title:  The Geological Record of Ocean Acidification: Tables

description: Ocean acidification may have severe consequences for marine ecosystems; however, assessing its future impact is difficult because laboratory experiments and field observations are limited by their reduced ecologic complexity and sample period, respectively. In contrast, the geological record contains long-term evidence for a variety of global environmental perturbations, including ocean acidification plus their associated biotic responses. We review events exhibiting evidence for elevated atmospheric CO2, global warming, and ocean acidification over the past ~300 million years of Earth's history, some with contemporaneous extinction or evolutionary turnover among marine calcifiers. Although similarities exist, no past event perfectly parallels future projections in terms of disrupting the balance of ocean carbonate chemistry—a consequence of the unprecedented rapidity of CO2 release currently taking place.
DOI: 10.7916/d8-arb7-9z72
title:  The Role of Theory of Mind and Wishful Thinking in Children’s Moralizing Concepts of the Abrahamic God (Study 2 Data)

description: Adults conceptualize God as particularly knowledgeable—more knowledgeable than humans—about moral transgressions. We investigated how younger (4- to 5-year-old) and older (6- to 7-year-old) children view God’s moral knowledge. Cultural narratives in the United States portray God as omniscient, which could lead children growing up in the United States to conclude that God knows their own and others’ behaviors. However, older children are better able to distinguish between different minds, and this ability (theory of mind, or TOM) may predict a tendency for older, versus younger, children to attribute greater knowledge to God. Consistent with the latter possibility, 6- to 7-year-olds viewed God as more knowledgeable of their own and others’ transgressions than did 4- to 5-year-olds. TOM partially mediated this difference. Further, children—particularly 4- to 5-year-olds—conceptualized God as more knowledgeable of others' transgressions than of their own. Study 2 probed whether 4- to 5- year-olds’ responses were due to wishful thinking (e.g., they did not want God to know their transgressions and therefore reported that God would lack this knowledge). Supporting this prediction, 4- to 5-year-olds attributed greater knowledge to God of their own, versus others’, pro-social acts. The extent to which children attributed knowledge of these acts to God predicted their own propensity to behave pro-socially by sharing with others. This work expands current understanding of religious cognition, particularly its connections with moral judgment and theory of mind.
DOI: 10.7916/d8-zhw7-8r98
title:  The Role of Theory of Mind and Wishful Thinking in Children’s Moralizing Concepts of the Abrahamic God (Study 1 Data)

description: Adults conceptualize God as particularly knowledgeable—more knowledgeable than humans—about moral transgressions. We investigated how younger (4- to 5-year-old) and older (6- to 7-year-old) children view God’s moral knowledge. Cultural narratives in the United States portray God as omniscient, which could lead children growing up in the United States to conclude that God knows their own and others’ behaviors. However, older children are better able to distinguish between different minds, and this ability (theory of mind, or TOM) may predict a tendency for older, versus younger, children to attribute greater knowledge to God. Consistent with the latter possibility, 6- to 7-year-olds viewed God as more knowledgeable of their own and others’ transgressions than did 4- to 5-year-olds. TOM partially mediated this difference. Further, children—particularly 4- to 5-year-olds—conceptualized God as more knowledgeable of others' transgressions than of their own. Study 2 probed whether 4- to 5- year-olds’ responses were due to wishful thinking (e.g., they did not want God to know their transgressions and therefore reported that God would lack this knowledge). Supporting this prediction, 4- to 5-year-olds attributed greater knowledge to God of their own, versus others’, pro-social acts. The extent to which children attributed knowledge of these acts to God predicted their own propensity to behave pro-socially by sharing with others. This work expands current understanding of religious cognition, particularly its connections with moral judgment and theory of mind.
DOI: 10.7916/d8bz7pms
title:  The mechanical response of the mouse cervix to tensile cyclic loading in term and preterm pregnancy: Data

description: These files contain mechanical data from a study evaluating the cyclic tensile loading properties of mouse cervices in normal gestation and 2 models of preterm birth. The exp_data folder contains a .xlsx files corresponding to each tested sample. Each file includes the experimental cyclic tensile data. The name of the file indicates the sample ID, which includes the the gestation day (NP = nonpregnant, d6 = gestation day 6, d12 = gestation day 12, d15 = gestation day 15, d18 = gestation day 18, d15LPS = infection PTB model on day 15, d15LPSsham = sham procedure of the infection model on day 15, d15RU486 = hormone withdrawal PTB model on day 15) and the sample number identifier. For example, “NP_1_raw_data” corresponds to the experimental data for nonpregnant sample #1 and “d6_3_raw_data” corresponds to the experimental data for gestation day 6 sample #3. In these files, the columns correspond to: the time [s], force [N], averaged cervical opening [mm], standard deviation of the cervical opening [mm], average width [mm], standard deviation of the width [mm], average length [mm], standard deviation of the length [mm], average height [mm], standard deviation of the height [mm], of the cervical sample. The cervical opening, average and standard deviation of the width, length, height, are determined via camera images. The time and force measurements are data from the universal testing machine.
DOI: 10.7916/d8kd1x8k
title:  The urgency of the development of CO2 capture from ambient air: Supporting information

description: CO2 capture and storage (CCS) has the potential to develop into an important tool to address climate change. Given society’s present reliance on fossil fuels, widespread adoption of CCS appears indispensable for meeting stringent climate targets. We argue that for conventional CCS to become a successful climate mitigation technology—which by necessity has to operate on a large scale—it may need to be complemented with air capture, removing CO2 directly from the atmosphere. Air capture of CO2 could act as insurance against CO2 leaking from storage and furthermore may provide an option for dealing with emissions from mobile dispersed sources such as automobiles and airplanes.