DOI: 10.6084/m9.figshare.29927002
title: Incidence and risk factors of acute kidney injury after abdominal surgery: a systematic review and meta-analysis

description: To determine the incidence of acute kidney injury (AKI) following abdominal surgery, assess its outcome associations, and identify factors associated with postoperative AKI development. We performed a systematic search of PubMed, Embase, and Cochrane Database of Systematic Reviews, from January 2004, to December 2024. We included studies reporting AKI based on consensus criteria (RIFLE, AKIN, or KDIGO) in adult abdominal surgery patients. A total of 162 studies (675361 patients) were included. The pooled AKI incidence was 16% (95% CI: 14-17%), with significant variation by surgical procedure. Meta-analysis showed AKI was significantly associated with increased short-term mortality (risk ratio [RR], 6.46; 95% CI: 4.63–9.00) and long-term mortality (RR, 6.36; 95% CI: 3.32–12.16). Mortality risk demonstrated stage-dependent increase, with RR of 2.74 (95%CI: 1.77–4.24), 8.01 (95%CI: 3.18–20.18), and 15.73 (95%CI: 5.52–44.81) for AKI stages 1, 2, and 3, respectively. AKI was associated with prolonged hospital stay (weighted mean difference 4.72 days; 95%CI: 3.43–6.02), also showeing stage-dependent increase of 5.03, 11.16, and 14.46 days for stages 1, 2, and 3, respectively. Twenty-five risk factors were associated with AKI. Meta-analysis of randomized controlled trials revealed that individualized blood pressure target management significantly reduced AKI incidence (RR, 0.67; 95% CI: 0.52–0.88). AKI remains a common and important complication after abdominal surgery, with severity showing a graded association with mortality and hospital stay. Individualized blood pressure management demonstrates promise in AKI prevention. PROSPERO CRD42022304083. The incidence of postoperative AKI after abdominal surgery is 16% (95% CI: 14–17%), varying by specific abdominal surgical procedure but not significantly different over time or by consensus definition.AKI severity shows a strong graded association with both short-term and long-term mortality, as well as prolonged hospital stays.Twenty-five factors were identified, providing valuable information for clinical risk assessment.Meta-analysis of randomized trials reveals that individualized blood pressure target management significantly reduces AKI incidence, while other single perioperative interventions (crystalloids versus colloids, restrictive versus liberal fluid management, cardiac output-guided therapy, hemodynamic monitoring) show no significant protective effects. The incidence of postoperative AKI after abdominal surgery is 16% (95% CI: 14–17%), varying by specific abdominal surgical procedure but not significantly different over time or by consensus definition. AKI severity shows a strong graded association with both short-term and long-term mortality, as well as prolonged hospital stays. Twenty-five factors were identified, providing valuable information for clinical risk assessment. Meta-analysis of randomized trials reveals that individualized blood pressure target management significantly reduces AKI incidence, while other single perioperative interventions (crystalloids versus colloids, restrictive versus liberal fluid management, cardiac output-guided therapy, hemodynamic monitoring) show no significant protective effects.