cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11609742
title: Magnetic Solid-Phase Microextraction for Lead Detection in Aqueous Samples Using Magnetite Nanoparticles

description: A magnetic solid-phase microextraction procedure was developed to detect lead in aqueous samples by flame atomic absorption spectrometry (FAAS). Fe3O4 nanoparticles were synthesized by coprecipitation and the crystalline phase was confirmed by X-ray diffraction. The point of zero charge (PZC) indicated that the oxide surface was negatively charged at pH levels above 9.4. pH 9.0 is the best for adsorption and the influence of stirring time and adsorbent mass were analyzed and set at 4 min and 3.0 mg, respectively. The best desorption conditions were obtained for 500 µL of 0.5 mol L-1 HNO3 as eluant. The limit of quantification (LOQ) and relative standard deviation (RSD) were 16.48 µg L-1 and 0.25%, respectively. The linear range was found to be 16.48‑500 µg L-1. The accuracy was evaluated by recovery tests in mineral water, micellar water and aqueous makeup remover samples, showing values in the range of 95.94 to 118%.
DOI: 10.6084/m9.figshare.11609745.v1
title: Tricuspid Valve Repair with Autologous Pericardium in a Patient with Infective Endocarditis

description: Abstract Infective endocarditis is a rather uncommon disease, but it has significant mortality rates in the pediatric population (5% to 10%). We report a case of an infant patient with multiple vegetation in the tricuspid valve secondary to infective endocarditis caused by Corynebacterium diphtheriae. A tricuspid valvuloplasty was performed with a fenestrated autologous pericardium patch, providing satisfactory outcomes. This technique is simple, innovative, effective, and it could be applied in similar cases.
DOI: 10.6084/m9.figshare.11609742.v1
title: Magnetic Solid-Phase Microextraction for Lead Detection in Aqueous Samples Using Magnetite Nanoparticles

description: A magnetic solid-phase microextraction procedure was developed to detect lead in aqueous samples by flame atomic absorption spectrometry (FAAS). Fe3O4 nanoparticles were synthesized by coprecipitation and the crystalline phase was confirmed by X-ray diffraction. The point of zero charge (PZC) indicated that the oxide surface was negatively charged at pH levels above 9.4. pH 9.0 is the best for adsorption and the influence of stirring time and adsorbent mass were analyzed and set at 4 min and 3.0 mg, respectively. The best desorption conditions were obtained for 500 µL of 0.5 mol L-1 HNO3 as eluant. The limit of quantification (LOQ) and relative standard deviation (RSD) were 16.48 µg L-1 and 0.25%, respectively. The linear range was found to be 16.48‑500 µg L-1. The accuracy was evaluated by recovery tests in mineral water, micellar water and aqueous makeup remover samples, showing values in the range of 95.94 to 118%.
DOI: 10.6084/m9.figshare.11609736
title: Assessment of remnant liver function and volume after selective ligation of portal vein and hepatic artery in a rat model

description: Abstract Purpose: To evaluate liver regeneration after selective ligation of portal vein and hepatic artery by 3D Computed Tomography in an experimental model. Methods: Sixteen Wistar rats were randomized into four equal groups: Group I- control (sham), Group II- isolated selective ligation of the hepatic artery, Group III- isolated selective ligation of the portal vein and Group IV- combined ligation of portal vein and hepatic artery. Before procedure and five days after a 3D CT Scan was performed to analyze the hypertrophy, weight and function of the remnant liver. Results: The largest regeneration rate and increase of weight in the hypertrophied lobe was detected in group IV, the first with an average of 3.99 (p=0.006) and the last varying from 6.10g to 9.64g (p=0.01). However, total liver weight and the R1 ratio (Hypertrophied Lobe Weight/Total Liver Weight) was higher in group III (P&lt;0.001) when compared with groups I, II and IV and showed no difference between them. The immunohistochemical examination with PCNA also found higher percentages with statistical significance differences in rats of groups III and IV. It was possible to confirm a strong correlation between hypertrophied lobe weight and its imaging volumetric study. Liver function tests only showed a significant difference in serum gamma-glutamyltransferase and phosphorous. Conclusion: There is a largest liver regeneration after combined ligation of portal vein and hepatic artery and this evidence may improve the knowledge of surgical treatment of liver injuries, with a translational impact in anima nobile.
DOI: 10.6084/m9.figshare.12864917
title: Additional file 6 of Safety studies and viral shedding of intramuscular administration of oncolytic vaccinia virus TG6002 in healthy beagle dogs

description: Additional file 6. Detection of virus shedding by qPCR assay after three intramuscular injections of TG6002. VACV DNA was not detected in blood, urine and saliva samples by qPCR assay from dogs treated with three successive injections of TG6002 at 5 × 107 PFU/kg. All samples were run in triplicate.
DOI: 10.6084/m9.figshare.11609736.v1
title: Assessment of remnant liver function and volume after selective ligation of portal vein and hepatic artery in a rat model

description: Abstract Purpose: To evaluate liver regeneration after selective ligation of portal vein and hepatic artery by 3D Computed Tomography in an experimental model. Methods: Sixteen Wistar rats were randomized into four equal groups: Group I- control (sham), Group II- isolated selective ligation of the hepatic artery, Group III- isolated selective ligation of the portal vein and Group IV- combined ligation of portal vein and hepatic artery. Before procedure and five days after a 3D CT Scan was performed to analyze the hypertrophy, weight and function of the remnant liver. Results: The largest regeneration rate and increase of weight in the hypertrophied lobe was detected in group IV, the first with an average of 3.99 (p=0.006) and the last varying from 6.10g to 9.64g (p=0.01). However, total liver weight and the R1 ratio (Hypertrophied Lobe Weight/Total Liver Weight) was higher in group III (P&lt;0.001) when compared with groups I, II and IV and showed no difference between them. The immunohistochemical examination with PCNA also found higher percentages with statistical significance differences in rats of groups III and IV. It was possible to confirm a strong correlation between hypertrophied lobe weight and its imaging volumetric study. Liver function tests only showed a significant difference in serum gamma-glutamyltransferase and phosphorous. Conclusion: There is a largest liver regeneration after combined ligation of portal vein and hepatic artery and this evidence may improve the knowledge of surgical treatment of liver injuries, with a translational impact in anima nobile.
DOI: 10.6084/m9.figshare.11609724
title: EXPERIMENTAL AND NUMERICAL ANALYSIS OF CHAOTIC ADVECTION AS AN EFFICIENT APPROACH TO MAXIMIZE HOMOGENEOUS LAMINAR MIXING IN A BATCH MIXER

description: Abstract In the present work, the impacts of effective parameters on the mixing of Stokes flows in a chaotic batch mixer are numerically and experimentally studied. The batch mixer consists of a container and two circular rotors where the rotors can rotate independently. To investigate the possibility of improving the mixing, the effect of non-constant speeds, contra-rotating rotors, and varying rotor speeds are studied. The results showed that varying the rotor speed while rotating in the same direction does not significantly increase mixing. However, if the rotors rotate in opposite directions, 10-times more mixing is achieved compared to the mode of rotating in the same direction. Nevertheless, given the constant speed of rotors, the flow is steady since the fluid particles have periodic movements in secondary flows, but the flow becomes chaotic and mixing is considerably increased by applying sinusoidal perturbations to the rotor speed. Nevertheless, for both modes of rotations in the same and opposite directions, the chaotic flow leads to increased mixing index in the same amount of time. Based on results, the best mixing results are achieved when the rotors rotate with sinusoidal rotational speed in opposite directions.
DOI: 10.6084/m9.figshare.11609733
title: THE IMPACT OF BRAZILIAN SAMBA ON PARKINSON’S DISEASE: ANALYSIS BY THE DISEASE SUBTYPES

description: ABSTRACT Introduction: People with Parkinson's disease constantly have low levels of physical activity. Dancing has become increasingly important for treating the disease and can help improve non-motor symptoms. Objective: To analyze the influence of Brazilian samba on the non-motor symptoms of PD according to TD and PGID subtypes. Methods: A 12-week, non-randomized clinical trial, through comparison with a control group. The 23 individuals who agreed to participate in the activities formed the experimental group (EG) and the 24 individuals who opted not to participate in the Brazilian samba classes comprised the control group (CG). A questionnaire was applied, composed of validated instruments. Mini Mental State Examination – MMSE; HY – Disability Scale; Unified Parkinson's Disease Rating Scale – UPDRS 1 and total values; Parkinson's Disease Questionnaire – PDQ-39, Parkinson's Disease Sleep Scale – PDSS; Beck Depression Inventory – BDI; Fatigue Severity Scale – FSS and Magnitude of Perceived Changes. Results: After the twelve weeks of intervention, it was observed that the EG showed improvement in the scores of all the tests. The comparison between groups, however, indicated a significant difference in the post-UPDRS1 period in which the EG presented improvement in cognitive impairment, while the CG presented a deficit in these values. The results of the division between disease subtypes show a greater change in the values between individuals of the TD group, when comparing the EG with the CG. For the EG, the greatest difference between pre- and post- intervention was fatigue. Conclusion: There was a positive trend in all the variables studied after the application of the protocol. This demonstrates that interventions such as dance may have greater effects on non-motor symptoms, depending on the expected progression of the disease. The scarcity of studies that use this approach in their analyses may explain the lack of evidence in this symptomatology related to dance. Level of evidence II; Therapeutic studies – Investigating the results of treatment.
DOI: 10.6084/m9.figshare.12864944
title: Additional file 2 of Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis

description: Additional file 2 :: Supplementary Table 4. Significant GO terms of genes differentially expressed at week 0 between responders and non-responders to anti-TNF therapy. Supplementary Table 5. Significant GO terms of genes differentially expressed at week 20 between responders and non-responders to anti-TNF therapy. Supplementary Table 6. Significant GO terms of genes differentially expressed between week 0 and week 20 in the responder group of patients.
DOI: 10.6084/m9.figshare.11609733.v1
title: THE IMPACT OF BRAZILIAN SAMBA ON PARKINSON’S DISEASE: ANALYSIS BY THE DISEASE SUBTYPES

description: ABSTRACT Introduction: People with Parkinson's disease constantly have low levels of physical activity. Dancing has become increasingly important for treating the disease and can help improve non-motor symptoms. Objective: To analyze the influence of Brazilian samba on the non-motor symptoms of PD according to TD and PGID subtypes. Methods: A 12-week, non-randomized clinical trial, through comparison with a control group. The 23 individuals who agreed to participate in the activities formed the experimental group (EG) and the 24 individuals who opted not to participate in the Brazilian samba classes comprised the control group (CG). A questionnaire was applied, composed of validated instruments. Mini Mental State Examination – MMSE; HY – Disability Scale; Unified Parkinson's Disease Rating Scale – UPDRS 1 and total values; Parkinson's Disease Questionnaire – PDQ-39, Parkinson's Disease Sleep Scale – PDSS; Beck Depression Inventory – BDI; Fatigue Severity Scale – FSS and Magnitude of Perceived Changes. Results: After the twelve weeks of intervention, it was observed that the EG showed improvement in the scores of all the tests. The comparison between groups, however, indicated a significant difference in the post-UPDRS1 period in which the EG presented improvement in cognitive impairment, while the CG presented a deficit in these values. The results of the division between disease subtypes show a greater change in the values between individuals of the TD group, when comparing the EG with the CG. For the EG, the greatest difference between pre- and post- intervention was fatigue. Conclusion: There was a positive trend in all the variables studied after the application of the protocol. This demonstrates that interventions such as dance may have greater effects on non-motor symptoms, depending on the expected progression of the disease. The scarcity of studies that use this approach in their analyses may explain the lack of evidence in this symptomatology related to dance. Level of evidence II; Therapeutic studies – Investigating the results of treatment.
DOI: 10.6084/m9.figshare.12864944.v1
title: Additional file 2 of Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis

description: Additional file 2 :: Supplementary Table 4. Significant GO terms of genes differentially expressed at week 0 between responders and non-responders to anti-TNF therapy. Supplementary Table 5. Significant GO terms of genes differentially expressed at week 20 between responders and non-responders to anti-TNF therapy. Supplementary Table 6. Significant GO terms of genes differentially expressed between week 0 and week 20 in the responder group of patients.
DOI: 10.6084/m9.figshare.11609724.v1
title: EXPERIMENTAL AND NUMERICAL ANALYSIS OF CHAOTIC ADVECTION AS AN EFFICIENT APPROACH TO MAXIMIZE HOMOGENEOUS LAMINAR MIXING IN A BATCH MIXER

description: Abstract In the present work, the impacts of effective parameters on the mixing of Stokes flows in a chaotic batch mixer are numerically and experimentally studied. The batch mixer consists of a container and two circular rotors where the rotors can rotate independently. To investigate the possibility of improving the mixing, the effect of non-constant speeds, contra-rotating rotors, and varying rotor speeds are studied. The results showed that varying the rotor speed while rotating in the same direction does not significantly increase mixing. However, if the rotors rotate in opposite directions, 10-times more mixing is achieved compared to the mode of rotating in the same direction. Nevertheless, given the constant speed of rotors, the flow is steady since the fluid particles have periodic movements in secondary flows, but the flow becomes chaotic and mixing is considerably increased by applying sinusoidal perturbations to the rotor speed. Nevertheless, for both modes of rotations in the same and opposite directions, the chaotic flow leads to increased mixing index in the same amount of time. Based on results, the best mixing results are achieved when the rotors rotate with sinusoidal rotational speed in opposite directions.
DOI: 10.6084/m9.figshare.11609718
title: Prevention of Pulmonary and Venous Thromboembolism Post Coronary Artery Bypass Graft Surgery – Literature Review

description: Abstract Objective: The current review evaluates recent literature on the different aspects of prophylaxis in postoperative pulmonary and venous thromboembolism and their main risk factors. Methods: The literature survey was carried out based on the PubMed data using the keywords “coronary artery bypass graft” and “venous thromboembolism” as components of the search field title. Results: Studies reported several risk factors for postoperative thromboembolism including advanced age, postoperative immobilization, type of thromboprophylaxis, obesity, and location of the surgery. Conclusion: According to the studies, tailored prophylaxis could be easily adapted to decrease the intensity and duration of postoperative thromboembolism in a patient with several disorders and comorbidities, especially in cardiovascular disease.
DOI: 10.6084/m9.figshare.11609715
title: Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma

description: ABSTRACT Purpose: Clear cell papillary (CCP) renal cell carcinoma (RCC) is a new subtype of RCC that was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013. Subsequently, CCP RCC was added to the 2016 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs. In this study, we retrospectively investigated the computed tomography (CT) findings of pathologically diagnosed CCP RCC. Materials and Methods: This study included 12 patients pathologically diagnosed with CCP RCC at our institution between 2015 and 2017. We reviewed the patient's CT data and analyzed the characteristics. Results: Nine solid masses and 3 cystic masses with a mean tumor size of 22.7±9.2mm were included. Solid masses exhibited slight hyper-density on unenhanced CT with a mean value of 34±6 Hounsfield units (HU), good enhancement in the corticomedullary phase with a mean of 195±34HU, and washout in the nephrogenic phase with a mean of 133±29HU. The walls of cystic masses enhanced gradually during the corticomedullary and nephrogenic phases. Solid and cystic masses were preoperatively diagnosed as clear cell RCC and cystic RCC, respectively. Conclusions: The CT imaging characteristics of CCP RCCs could be categorized into either the solid or cystic type. These masses were diagnosed radiologically as clear cell RCC and cystic RCC, respectively.
DOI: 10.6084/m9.figshare.11609718.v1
title: Prevention of Pulmonary and Venous Thromboembolism Post Coronary Artery Bypass Graft Surgery – Literature Review

description: Abstract Objective: The current review evaluates recent literature on the different aspects of prophylaxis in postoperative pulmonary and venous thromboembolism and their main risk factors. Methods: The literature survey was carried out based on the PubMed data using the keywords “coronary artery bypass graft” and “venous thromboembolism” as components of the search field title. Results: Studies reported several risk factors for postoperative thromboembolism including advanced age, postoperative immobilization, type of thromboprophylaxis, obesity, and location of the surgery. Conclusion: According to the studies, tailored prophylaxis could be easily adapted to decrease the intensity and duration of postoperative thromboembolism in a patient with several disorders and comorbidities, especially in cardiovascular disease.
DOI: 10.6084/m9.figshare.11609715.v1
title: Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma

description: ABSTRACT Purpose: Clear cell papillary (CCP) renal cell carcinoma (RCC) is a new subtype of RCC that was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013. Subsequently, CCP RCC was added to the 2016 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs. In this study, we retrospectively investigated the computed tomography (CT) findings of pathologically diagnosed CCP RCC. Materials and Methods: This study included 12 patients pathologically diagnosed with CCP RCC at our institution between 2015 and 2017. We reviewed the patient's CT data and analyzed the characteristics. Results: Nine solid masses and 3 cystic masses with a mean tumor size of 22.7±9.2mm were included. Solid masses exhibited slight hyper-density on unenhanced CT with a mean value of 34±6 Hounsfield units (HU), good enhancement in the corticomedullary phase with a mean of 195±34HU, and washout in the nephrogenic phase with a mean of 133±29HU. The walls of cystic masses enhanced gradually during the corticomedullary and nephrogenic phases. Solid and cystic masses were preoperatively diagnosed as clear cell RCC and cystic RCC, respectively. Conclusions: The CT imaging characteristics of CCP RCCs could be categorized into either the solid or cystic type. These masses were diagnosed radiologically as clear cell RCC and cystic RCC, respectively.
DOI: 10.6084/m9.figshare.11609703
title: Acid-Catalyzed Z-E Isomerization of γ-Alkylidenebutenolides: An Experimental and DFT Study

description: The Z-E isomerization of γ-alkylidenebutenolide analogues to natural nostoclides and other natural butenolides was investigated using 1H nuclear magnetic resonance (NMR) and high performance liquid chromatography (HPLC) data as well as density functional theory (DFT) calculations at the wB97x-D/6-31G(d,p) level, including solvent effects with the polarizable continuum solvation approach. The experimental data supported the Z to E isomerization of γ-alkylidenebutenolides under acid catalysis. Newly prepared samples have predominantly Z configuration, which partially isomerizes to the E isomer under acidic conditions. Density functional theory studies corroborate the experimental findings. While neutral γ-alkylidenebutenolides are more stable in the Z form, protonation of the γ-lactone carbonyl group results in preferential stabilization of the E isomer.
DOI: 10.6084/m9.figshare.11609703.v1
title: Acid-Catalyzed Z-E Isomerization of γ-Alkylidenebutenolides: An Experimental and DFT Study

description: The Z-E isomerization of γ-alkylidenebutenolide analogues to natural nostoclides and other natural butenolides was investigated using 1H nuclear magnetic resonance (NMR) and high performance liquid chromatography (HPLC) data as well as density functional theory (DFT) calculations at the wB97x-D/6-31G(d,p) level, including solvent effects with the polarizable continuum solvation approach. The experimental data supported the Z to E isomerization of γ-alkylidenebutenolides under acid catalysis. Newly prepared samples have predominantly Z configuration, which partially isomerizes to the E isomer under acidic conditions. Density functional theory studies corroborate the experimental findings. While neutral γ-alkylidenebutenolides are more stable in the Z form, protonation of the γ-lactone carbonyl group results in preferential stabilization of the E isomer.