cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12300872.v2
title: text_figures_tables.zip from Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats

description: Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical <i>in silico</i> cardiac models offer a systematic approach for studying these multi-scale interactions. The computational cost of such models is high, due to their multi-parametric and nonlinear nature. This has so far made it difficult to perform model fitting and prevented global sensitivity analysis (GSA) studies. We propose a machine learning approach based on Gaussian process emulation of model simulations using probabilistic surrogate models, which enables model parameter inference via a Bayesian history matching (HM) technique and GSA on whole-organ mechanics. This framework is applied to model healthy and aortic-banded hypertensive rats, a commonly used animal model of heart failure disease. The obtained probabilistic surrogate models accurately predicted the left ventricular pump function (R<sup>2</sup> = 0.92 for ejection fraction). The HM technique allowed us to fit both the control and diseased virtual bi-ventricular rat heart models to magnetic resonance imaging and literature data, with model outputs from the constrained parameter space falling within 2 SD of the respective experimental values. The GSA identified Troponin C and cross-bridge kinetics as key parameters in determining both systolic and diastolic ventricular function.This article is part of the theme issue ‘Uncertainty quantification in cardiac and cardiovascular modelling and simulation’.
DOI: 10.6084/m9.figshare.12300872.v1
title: text_figures_tables.zip from Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats. 27 April 2020

description: Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical <i>in silico</i> cardiac models offer a systematic approach for studying these multi-scale interactions. The computational cost of such models is high, due to their multi-parametric and nonlinear nature. This has so far made it difficult to perform model fitting and prevented global sensitivity analysis (GSA) studies. We propose a machine learning approach based on Gaussian process emulation of model simulations using probabilistic surrogate models, which enables model parameter inference via a Bayesian history matching (HM) technique and GSA on whole-organ mechanics. This framework is applied to model healthy and aortic-banded hypertensive rats, a commonly used animal model of heart failure disease. The obtained probabilistic surrogate models accurately predicted the left ventricular pump function (R<sup>2</sup> = 0.92 for ejection fraction). The HM technique allowed us to fit both the control and diseased virtual bi-ventricular rat heart models to magnetic resonance imaging and literature data, with model outputs from the constrained parameter space falling within 2 SD of the respective experimental values. The GSA identified Troponin C and cross-bridge kinetics as key parameters in determining both systolic and diastolic ventricular function.This article is part of the theme issue ‘Uncertainty quantification in cardiac and cardiovascular modelling and simulation’.
DOI: 10.6084/m9.figshare.12300824
title: SARSCoV-Human network

description: It contains interactions between SARSCoV and human proteins.<br>
DOI: 10.6084/m9.figshare.12300824.v1
title: SARSCoV-Human network

description: It contains interactions between SARSCoV and human proteins.<br>
DOI: 10.6084/m9.figshare.12300806
title: SARSCoV SARSCoV interactions

description: It contains interactions between SARSCoV and SARSCoV protein.<br>
DOI: 10.6084/m9.figshare.12300812
title: Dataset 1 from ‘What I cannot create, I do not understand’: functionally validated synergism of metabolic and target site insecticide resistance

description: This file contains the raw data used for the determination of life table paraeters
DOI: 10.6084/m9.figshare.12300806.v1
title: SARSCoV SARSCoV interactions

description: It contains interactions between SARSCoV and SARSCoV protein.<br>
DOI: 10.6084/m9.figshare.12300812.v1
title: Dataset 1 from ‘What I cannot create, I do not understand’: functionally validated synergism of metabolic and target site insecticide resistance

description: This file contains the raw data used for the determination of life table paraeters
DOI: 10.6084/m9.figshare.12300764
title: Supplementary Material--Phenotypes, genotypes and treatment outcomes in CHH.xlsx

description: Supplementary datasets for the article:<b>Genetic profiles and three-year follow-up study of Chinese patients with congenital hypogonadotropic hypogonadism.</b><b></b>PCR primers, detailed clinical data, variant interpretation process, CT/MRI result, pedigreees, etc. were included.
DOI: 10.6084/m9.figshare.12300170
title: Supplementary Data

description: The file "Source Data" contains all raw data and full SDS gel images.<br>The file Supplementary Table 3 contains results from Mass Spectrometry on three individual samples of mitochondria. <br>
DOI: 10.6084/m9.figshare.12300353
title: Supplementary Data.pdf

description: Primer sequences
DOI: 10.6084/m9.figshare.12300047
title: Transcriptome analysis in liver of Eospalax fontanierii under hypoxia

description: Table S5. GO enrichment of DEGs in response to hypoxia.
DOI: 10.6084/m9.figshare.12300158
title: Transcriptome analysis in liver of Eospalax fontanierii under hypoxia

description: <b>Supplemental Table S6</b>. <b>KEGG enrichment of DEGs in response to hypoxia.</b>
DOI: 10.6084/m9.figshare.12300353.v1
title: Supplementary Data.pdf

description: Primer sequences
DOI: 10.6084/m9.figshare.12300170.v2
title: Source_Data.xlsx

description: The file "Source Data" contains all raw data and full SDS gel images.The file Supplementary Table 3 contains results from Mass Spectrometry on three individual samples of mitochondria. <br>
DOI: 10.6084/m9.figshare.12300158.v1
title: Transcriptome analysis in liver of Eospalax fontanierii under hypoxia

description: <b>Supplemental Table S6</b>. <b>KEGG enrichment of DEGs in response to hypoxia.</b>
DOI: 10.6084/m9.figshare.12300170.v1
title: Source_Data.xlsx

description: Raw data and full SDS gel images.<br>
DOI: 10.6084/m9.figshare.12299930
title: Transcriptome analysis in liver of Eospalax fontanierii under hypoxia

description: Suppplemental TableS4: Unigene expression and annotation informations
DOI: 10.6084/m9.figshare.12300047.v1
title: Transcriptome analysis in liver of Eospalax fontanierii under hypoxia

description: Table S5. GO enrichment of DEGs in response to hypoxia.
DOI: 10.6084/m9.figshare.12299930.v2
title: Transcriptome analysis in liver of Eospalax fontanierii under hypoxia

description: Suppplemental TableS4: Unigene expression and annotation informations
DOI: 10.6084/m9.figshare.12299879
title: Additional file 9 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 9: Supplemental Table 1. Summary statistics of the study cohort.
DOI: 10.6084/m9.figshare.12299879.v1
title: Additional file 9 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 9: Supplemental Table 1. Summary statistics of the study cohort.
DOI: 10.6084/m9.figshare.12299861
title: Additional file 2 of Probiotics use for antibiotic-associated diarrhea: a pragmatic participatory evaluation in nursing homes

description: Additional file 2. Raw data of the probiotics evaluation
DOI: 10.6084/m9.figshare.12299858
title: Additional file 5 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 5: Supplemental Data 5. eQTLs associated with WGCNA genes.
DOI: 10.6084/m9.figshare.12299849
title: Additional file 4 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 4: Supplemental Data 4. Annotation of WGCNA modules.
DOI: 10.6084/m9.figshare.12299861.v1
title: Additional file 2 of Probiotics use for antibiotic-associated diarrhea: a pragmatic participatory evaluation in nursing homes

description: Additional file 2. Raw data of the probiotics evaluation
DOI: 10.6084/m9.figshare.12299849.v1
title: Additional file 4 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 4: Supplemental Data 4. Annotation of WGCNA modules.
DOI: 10.6084/m9.figshare.12299858.v1
title: Additional file 5 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 5: Supplemental Data 5. eQTLs associated with WGCNA genes.
DOI: 10.6084/m9.figshare.12299828
title: Additional file 13 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 13: Supplemental Table 5. BRCA targeted analysis.
DOI: 10.6084/m9.figshare.12299822
title: Additional file 12 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 12: Supplemental Table 4. List of all WGCNA modules.
DOI: 10.6084/m9.figshare.12299822.v1
title: Additional file 12 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 12: Supplemental Table 4. List of all WGCNA modules.
DOI: 10.6084/m9.figshare.12299828.v1
title: Additional file 13 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 13: Supplemental Table 5. BRCA targeted analysis.
DOI: 10.6084/m9.figshare.12299801
title: Additional file 10 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 10: Supplemental Table 2. Adjuvant treatments given to patients in the study cohort.
DOI: 10.6084/m9.figshare.12299807
title: Additional file 11 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 11: Supplemental Table 3. List of all differentially expressed genes.
DOI: 10.6084/m9.figshare.12299807.v1
title: Additional file 11 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 11: Supplemental Table 3. List of all differentially expressed genes.
DOI: 10.6084/m9.figshare.12299801.v1
title: Additional file 10 of Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer

description: Additional file 10: Supplemental Table 2. Adjuvant treatments given to patients in the study cohort.
DOI: 10.6084/m9.figshare.12299723
title: Additional file 2 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

description: Additional file 2. Excel file of raw data and kNN-imputed data, RawAndImputedData.xlsx
DOI: 10.6084/m9.figshare.12299723.v1
title: Additional file 2 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

description: Additional file 2. Excel file of raw data and kNN-imputed data, RawAndImputedData.xlsx
DOI: 10.6084/m9.figshare.12299711
title: Additional file 1 of Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

description: Additional file 1. The additional data table includes plasmepsin 2/3 copy number estimates using the various methods tested in this manuscript (SYBR qPCR, TaqMan qPCR, and breakpoint PCR) compared to whole genome sequencing (WGS) data, when available. Parasite density is listed at time 0 (upon enrollment) when the samples were collected as dried blood spots (DBS) or whole blood (WB), from which gDNA was later extracted.
DOI: 10.6084/m9.figshare.12299711.v1
title: Additional file 1 of Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

description: Additional file 1. The additional data table includes plasmepsin 2/3 copy number estimates using the various methods tested in this manuscript (SYBR qPCR, TaqMan qPCR, and breakpoint PCR) compared to whole genome sequencing (WGS) data, when available. Parasite density is listed at time 0 (upon enrollment) when the samples were collected as dried blood spots (DBS) or whole blood (WB), from which gDNA was later extracted.
DOI: 10.6084/m9.figshare.12299699
title: Additional file 1 of Oxidation during magma mixing recorded by symplectites at Kusatsu–Shirane Volcano, Central Japan

description: Additional file 1. Excel Spreadsheet with representative EPMA results (Figs. 4 and 5).
DOI: 10.6084/m9.figshare.12299699.v1
title: Additional file 1 of Oxidation during magma mixing recorded by symplectites at Kusatsu–Shirane Volcano, Central Japan

description: Additional file 1. Excel Spreadsheet with representative EPMA results (Figs. 4 and 5).
DOI: 10.6084/m9.figshare.12299567
title: Additional file 2 of Postpartum vitamin A supplementation for HIV-positive women is not associated with mortality and morbidity of their breastfed infants: evidence from multiple national surveys in sub-Saharan Africa

description: Additional file 2.
DOI: 10.6084/m9.figshare.12299555
title: Additional file 6 of Social and ecological outcomes of conservation interventions in tropical coastal marine ecosystems: a systematic map protocol

description: Additional file 6. Data coding questionnaire.
DOI: 10.6084/m9.figshare.12299555.v1
title: Additional file 6 of Social and ecological outcomes of conservation interventions in tropical coastal marine ecosystems: a systematic map protocol

description: Additional file 6. Data coding questionnaire.
DOI: 10.6084/m9.figshare.12299567.v1
title: Additional file 2 of Postpartum vitamin A supplementation for HIV-positive women is not associated with mortality and morbidity of their breastfed infants: evidence from multiple national surveys in sub-Saharan Africa

description: Additional file 2.
DOI: 10.6084/m9.figshare.12299546
title: Additional file 5 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 5: ncHAE.data.
DOI: 10.6084/m9.figshare.12299537
title: Additional file 4 of Social and ecological outcomes of conservation interventions in tropical coastal marine ecosystems: a systematic map protocol

description: Additional file 4. Evolution of search string.
DOI: 10.6084/m9.figshare.12299546.v1
title: Additional file 5 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 5: ncHAE.data.
DOI: 10.6084/m9.figshare.12299534
title: Additional file 4 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 4: DHS.data.
DOI: 10.6084/m9.figshare.12299528
title: Additional file 3 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 3: NFR.data.
DOI: 10.6084/m9.figshare.12299531
title: Additional file 3 of Social and ecological outcomes of conservation interventions in tropical coastal marine ecosystems: a systematic map protocol

description: Additional file 3. ROSES form for systematic map protocols.
DOI: 10.6084/m9.figshare.12299537.v1
title: Additional file 4 of Social and ecological outcomes of conservation interventions in tropical coastal marine ecosystems: a systematic map protocol

description: Additional file 4. Evolution of search string.
DOI: 10.6084/m9.figshare.12299528.v1
title: Additional file 3 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 3: NFR.data.
DOI: 10.6084/m9.figshare.12299534.v1
title: Additional file 4 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 4: DHS.data.
DOI: 10.6084/m9.figshare.12299519
title: Additional file 2 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 2: NFR.sorted.bed.csv.
DOI: 10.6084/m9.figshare.12299531.v1
title: Additional file 3 of Social and ecological outcomes of conservation interventions in tropical coastal marine ecosystems: a systematic map protocol

description: Additional file 3. ROSES form for systematic map protocols.
DOI: 10.6084/m9.figshare.12299519.v1
title: Additional file 2 of Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

description: Additional file 2: NFR.sorted.bed.csv.
DOI: 10.6084/m9.figshare.12860837
title: GPS data

description: HKPC, HKOH, HKST14 September 2013 to 2 October 2013
DOI: 10.6084/m9.figshare.12299462
title: Additional file 2 of Prospective monitoring of imaging guideline adherence by physicians in a surgical collaborative: comparison of statistical process control methods for detecting outlying performance

description: Additional file 2. Ethics Statement Supplement. Contains details of MUSIC practices’ IRB status.
DOI: 10.6084/m9.figshare.12299462.v1
title: Additional file 2 of Prospective monitoring of imaging guideline adherence by physicians in a surgical collaborative: comparison of statistical process control methods for detecting outlying performance

description: Additional file 2. Ethics Statement Supplement. Contains details of MUSIC practices’ IRB status.
DOI: 10.6084/m9.figshare.12299447
title: Additional file 1 of The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning

description: Additional file 1: Supplementary file 1. Data for Fig. 5 as Excel file.
DOI: 10.6084/m9.figshare.12299447.v1
title: Additional file 1 of The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning

description: Additional file 1: Supplementary file 1. Data for Fig. 5 as Excel file.
DOI: 10.6084/m9.figshare.12299408
title: Additional file 1 of TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

description: Additional file 1.
DOI: 10.6084/m9.figshare.12299408.v1
title: Additional file 1 of TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

description: Additional file 1.
DOI: 10.6084/m9.figshare.12299333
title: Additional file 5 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 5. Training dataset including descriptors for model training in KNIME.
DOI: 10.6084/m9.figshare.12299333.v1
title: Additional file 5 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 5. Training dataset including descriptors for model training in KNIME.
DOI: 10.6084/m9.figshare.12299324
title: Additional file 4 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 4. KNIME workflow to train the selectivity-window model.
DOI: 10.6084/m9.figshare.12299318
title: Additional file 3 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 3. Protocol to train the selectivity-window model and to apply the model in screening.
DOI: 10.6084/m9.figshare.12299324.v1
title: Additional file 4 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 4. KNIME workflow to train the selectivity-window model.
DOI: 10.6084/m9.figshare.12299312
title: Additional file 1 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 1. Compound data used in training and validation (compound smiles and activities).
DOI: 10.6084/m9.figshare.12299318.v1
title: Additional file 3 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 3. Protocol to train the selectivity-window model and to apply the model in screening.
DOI: 10.6084/m9.figshare.12299312.v1
title: Additional file 1 of Quantitative prediction of selectivity between the A1 and A2A adenosine receptors

description: Additional file 1. Compound data used in training and validation (compound smiles and activities).
DOI: 10.6084/m9.figshare.12299291
title: Additional file 5 of Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia

description: Additional file 5: Raw data of thickness of laterite blocks used for the bridge construction along the East Royal Road.
DOI: 10.6084/m9.figshare.12299288
title: Additional file 4 of Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia

description: Additional file 4: Raw data of magnetic susceptibilities of sandstone blocks used for the bridge construction along the East Royal Road.
DOI: 10.6084/m9.figshare.12299288.v1
title: Additional file 4 of Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia

description: Additional file 4: Raw data of magnetic susceptibilities of sandstone blocks used for the bridge construction along the East Royal Road.
DOI: 10.6084/m9.figshare.12299276
title: Additional file 1 of Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia

description: Additional file 1: Data used for the cluster and principal component analyses. The median concentrations of each element and magnetic susceptibility data listed in Table 1 were standardised to a constant total.
DOI: 10.6084/m9.figshare.12299279
title: Additional file 2 of Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia

description: Additional file 2: Raw data of chemical composition analysis of laterite blocks used for the bridge construction along the East Royal Road by a portable XRF.
DOI: 10.6084/m9.figshare.12299282
title: Additional file 3 of Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia

description: Additional file 3: Raw data of magnetic susceptibilities of laterite blocks used for the bridge construction along the East Royal Road.