cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26840461
title: Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019–2023)

description: Protein kinases play a key role in cellular signaling pathways including proliferation, apoptosis, inflammation and immune regulation. Therefore, targeting kinases with small molecules has emerged as a therapeutic potential in cancers and other diseases including inflammatory and autoimmune disorders. The main chemical motifs of the available small molecule kinase inhibitors are heterocyclic, nitrogen-containing and six-membered rings including pyrazine. Several potent and selective pyrazine-based kinase inhibitors have been developed and progressed into clinical trials. The data of clinical application of kinase inhibitors demonstrate good clinical activity with manageable toxicity in several relapse-resistant malignancies and severe to moderate immunological disorders. All pyrazine-based kinase inhibitors are orally active. This paper reviews the most recent kinase literature (2019–2023) related to pyrazine-based small molecule inhibitors. This review includes the FDA (Food and Drug Administration)-approved and patent agents along with their targeted kinase, scaffold, potency, selectivity profile, assignee and biological results in clinical and preclinical studies. The main chemical scaffolds of pyrazine-based small molecule inhibitors were imadazopyrazines, pyrazolopyrazines, triazolopyrazines, pyrazinopyrazines and 2-aminopyrazines. Various potent, selective and orally active pyrazine-based kinase inhibitors have been developed and progressed into clinical trials. The results of clinical applications of kinase inhibitors indicate clinical activity with manageable toxicity in a number of relapse-resistant malignancies, and severe to moderate immunological disorders. Most pyrazine-based kinase inhibitors act as ATP-competitive and bind to the ATP binding pocket of the active or inactive form of the enzyme, reversibly through hydrogen bonding and hydrophobic interactions or irreversible through covalent bonding. Resistance of malignant cells to kinase therapy is common and mainly due to mutation of the gatekeeper residue of the enzyme.
DOI: 10.6084/m9.figshare.26840461.v1
title: Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019–2023)

description: Protein kinases play a key role in cellular signaling pathways including proliferation, apoptosis, inflammation and immune regulation. Therefore, targeting kinases with small molecules has emerged as a therapeutic potential in cancers and other diseases including inflammatory and autoimmune disorders. The main chemical motifs of the available small molecule kinase inhibitors are heterocyclic, nitrogen-containing and six-membered rings including pyrazine. Several potent and selective pyrazine-based kinase inhibitors have been developed and progressed into clinical trials. The data of clinical application of kinase inhibitors demonstrate good clinical activity with manageable toxicity in several relapse-resistant malignancies and severe to moderate immunological disorders. All pyrazine-based kinase inhibitors are orally active. This paper reviews the most recent kinase literature (2019–2023) related to pyrazine-based small molecule inhibitors. This review includes the FDA (Food and Drug Administration)-approved and patent agents along with their targeted kinase, scaffold, potency, selectivity profile, assignee and biological results in clinical and preclinical studies. The main chemical scaffolds of pyrazine-based small molecule inhibitors were imadazopyrazines, pyrazolopyrazines, triazolopyrazines, pyrazinopyrazines and 2-aminopyrazines. Various potent, selective and orally active pyrazine-based kinase inhibitors have been developed and progressed into clinical trials. The results of clinical applications of kinase inhibitors indicate clinical activity with manageable toxicity in a number of relapse-resistant malignancies, and severe to moderate immunological disorders. Most pyrazine-based kinase inhibitors act as ATP-competitive and bind to the ATP binding pocket of the active or inactive form of the enzyme, reversibly through hydrogen bonding and hydrophobic interactions or irreversible through covalent bonding. Resistance of malignant cells to kinase therapy is common and mainly due to mutation of the gatekeeper residue of the enzyme.
DOI: 10.15468/dl.ysaukh
title: Occurrence Download

description: A dataset containing 896 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation, Literature Occurrence, Living Specimen, Unknown evidence, Occurrence evidence, Specimen, Machine Observation)",
 "Geometry POLYGON((144.30599 -44.02684,147.18728 -44.02684,147.18728 -40.28895,144.30599 -40.28895,144.30599 -44.02684))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Aneuraceae"
 ]
}

 The dataset includes 896 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006107-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8p7a74
title: Occurrence Download

description: A dataset containing 19 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Paphiopedilum acmodontum M.W.Wood"
 ]
}

 The dataset includes 19 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006108-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jbmmau
title: Occurrence Download

description: A dataset containing 873 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Europe",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "MediaType is Image",
 "TaxonKey is Cakile maritima Scop.",
 "Year 2003-2013"
 ]
}

 The dataset includes 873 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006109-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jz9pgn
title: Occurrence Download

description: A dataset containing 7052 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Europe",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "MediaType is Image",
 "PublishingOrg is 28eb1a3f-1c15-4a95-931a-4af90ecb574d",
 "TaxonKey is Cakile maritima Scop.",
 "Year 2014-2024"
 ]
}

 The dataset includes 7052 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006110-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u8aghu
title: Occurrence Download

description: A dataset containing 67 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Philodendron spiritus-sancti G.S.Bunting"
 ]
}

 The dataset includes 67 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006111-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/37h5cr5z27.1
title: Supplemental Table I. Excess skin removal procedures

description: A list of excess skin removal procedures (body contouring surgeries) that we searched for in our institution's electronic medical records for patients diagnosed with Hidradenitis suppurativa
DOI: 10.15468/dl.uwqubq
title: Occurrence Download

description: A dataset containing 1074 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Mauritania",
 "TaxonKey is Perciformes"
 ]
}

 The dataset includes 1074 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006113-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.23708/f7fc145d-3a94-4915-9c79-880b26bf4e7d
title: Cartographie pilote des éléments paysagers linéaires. Bassin d'alimentation du barrage Lebna, Tunisie. Mai 2023.
title: Preliminary mapping of linear landscape elements. Lebna dam catchment area, Tunis. May 2023.

description: La description des configurations spatiales des systèmes de culture est nécessaire pour en comprendre l’organisation et explorer des scénarios d’évolution plausibles. De multiples données sont nécessaires pour cette description, qui doit couvrir les séquences de cultures et les pratiques associées. Cependant, la disponibilité et l'exhaustivité des données est très variable, en fonction de la région et du niveau spatial d'intérêt. Cette étude se focalise sur la caractérisation des composantes linéaires (chemins, limites parcellaires, haies, réseau hydrographique, …) d’un paysage agricole méditerranéen dans un contexte de polyculture-élevage en pluvial. L’objectif est de comprendre l’impact des éléments linéaires sur l'organisation spatiale des assolements. Sur la base de la littérature existante, nous avons identifié les critères de description et classification de ces éléments linéaires liés à des indicateurs visuels. Une campagne de relevés terrain a été menée pour valider la classification et compléter les données existantes. La classification porte sur deux critères d’intérêt agronomique: origine (anthropique ou naturelle), et niveau de porosité latérale: non franchissable, franchissable par des machines, des animaux ou des humains. Des analyses statistiques spatiales permettront d’explorer le rôle de barrière ou jonction que peuvent jouer les éléments linéaires paysagers dans la définition de clusters de systèmes de cultures (assolements partagés) dans le bassin versant du Lebna, en Tunisie.
description: Describing the spatial configurations of cropping systems is necessary to understand how they are organized and explore plausible change scenarios. A wide range of data is required for this description, covering cropping sequences and associated practices. However, the availability and completeness of the data vary greatly, depending on the region and the spatial level of interest. This study focuses on characterising linear elements (paths, field boundaries, hedges, hydrographic network, etc.) of a Mediterranean agricultural landscape in the context of rain-fed mixed cropping livestock farming. The aim is to understand the impact of linear elements on the spatial organisation of crop rotations. Based on existing literature, we identified criteria for describing and classifying these linear elements using visual indicators. A field survey was realized to validate the classification and supplement the existing data. The classification is based on two criteria of agronomic interest: origin (anthropogenic or natural), and level of lateral porosity: non-crossable, crossable by machines, animals or humans. Spatial statistical analyses will allow exploring the role of barrier or junction that linear landscape elements can play in defining clusters of cropping systems (shared crop rotation) in the Lebna catchment, in Tunisia.
DOI: 10.5281/zenodo.13887061
title: HelioSwarm Representative Trajectories

description: The HelioSwarm Flight Dynamics team prepares representative trajectories for use in mission planning. As these can be useful for developing analysis techniques, the HelioSwarm team provides these to the community. They are provided in the form of summary files which will eventually evolve to be similar to a product planned during science operations; however, both the contents and the details of the format are preliminary!

The exact configurations will change rapidly; in particular, the representative trajectories do not represent a prediction of actual positions during the mision.

If you use these configurations for any analysis, please make note of the file version number and the corresponding reference design. Current version 0.2.0 of the summary files uses Swarm Reference Design 5B, Flight System Transfer Trajectory 0x75b, dated 2024-06-24.

Most other details of the file format are in the CDF attributes.
DOI: 10.5281/zenodo.13887062
title: HelioSwarm Representative Trajectories

description: The HelioSwarm Flight Dynamics team prepares representative trajectories for use in mission planning. As these can be useful for developing analysis techniques, the HelioSwarm team provides these to the community. They are provided in the form of summary files which will eventually evolve to be similar to a product planned during science operations; however, both the contents and the details of the format are preliminary!

The exact configurations will change rapidly; in particular, the representative trajectories do not represent a prediction of actual positions during the mision.

If you use these configurations for any analysis, please make note of the file version number and the corresponding reference design. Current version 0.2.0 of the summary files uses Swarm Reference Design 5B, Flight System Transfer Trajectory 0x75b, dated 2024-06-24.

Most other details of the file format are in the CDF attributes.
DOI: 10.17630/d6f18c09-5a51-45a6-82f7-6438b0cb80a6
title: Scotland's Sedimentary Blue Carbon: New Spatial Tools for Seabed Management (thesis data)

description: Raw and processed datasets all data that were created/collected and have been used to answer the research questions within the PhD Thesis. The datasets mainly comprise analytical biogeochemical measurements for seabed sediments in addition to final spatial products that have been published in manuscripts.
DOI: 10.15468/dl.t5d8pv
title: Occurrence Download

description: A dataset containing 198 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Breeding success of Southern Australian little penguins, Australia (1990-2017)"
 ]
}

 The dataset includes 198 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006117-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7yms75
title: Occurrence Download

description: A dataset containing 1166 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Reynoutria japonica Houtt.",
 "Country is Luxembourg"
 ]
}

 The dataset includes 1166 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006118-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27203571
title: Data

description: Sewer pipes properties and structural condition
DOI: 10.6084/m9.figshare.27203571.v1
title: Data

description: Sewer pipes properties and structural condition
DOI: 10.17630/4fe7ae1c-9e0d-4671-a795-f29cb64d504c
title: Data underpinning: Snapshot hyperspectral imaging of intracellular lasers
DOI: 10.15468/dl.tbymys
title: Occurrence Download

description: A dataset containing 534 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Telmatobius culeus (Garman, 1876)"
 ]
}

 The dataset includes 534 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006119-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17630/301fa354-0637-4065-a526-fbc7c3a3f462
title: Light-mediated catalytic enantioselective difluoroalkylation of β-ketoesters via phase-transfer catalysis (dataset)

description: The data files are not yet publicly available. Enquiries and requests for data should be directed to the publication's corresponding authors: Craig Paterson Johnston & Callum Adams
DOI: 10.6084/m9.figshare.27203628
title: Research data-Lake Buridun

description: Research data-Lake Buridun, including Pollen and TOC.Research Paper: Seesaw between the Westerlies and Asian monsoon regulates vegetation and climate during the last deglaciation in southern Northeast China
DOI: 10.57830/2306333
title: Riparian Vegetation Structure and Composition of Wadeable Streams Monitoring for the Northern Colorado Plateau Network: 2008-2021 – Raw Data

description: Because of the scarcity of water on the Colorado Plateau and their disproportionately high use by flora and fauna, riparian areas have been identified as an ecosystem of concern for Northern Colorado Plateau Network (NCPN) parks. Riparian ecosystems are potentially sensitive indicators of landscape-level change because they are linked to both aquatic and upland systems, perform important ecological functions, and are biologically diverse. Riparian systems face a number of anthropogenic threats, including stream-flow damming or diversion, channel-stabilization structures, invasive exotic species, livestock grazing, timber harvesting, agricultural clearing, groundwater pumping, and trail creation. These disturbances can alter watershed conditions and directly or indirectly influence downstream riparian ecosystems.

In the Northern Colorado Plateau Network, riparian monitoring of wadeable streams occurs in the streams of four parks: Courthouse Wash in Arches National Park, Armstrong Canyon in Natural Bridges National Monument, the Fremont River in Capitol Reef National Park, and the East Fork Virgin River in Zion National Park. This data package pertains to the vital sign riparian vegetation structure and composition. The goal for monitoring this vital sign is to determine long-term trends in vegetation dynamics in the context of changes in other ecological drivers, stressors, and processes. Above-ground structures of riparian plants modify the physical environment by shading and depositing litter, strongly affecting spatial and temporal patterns of soil-resource availability to other organisms. The data herein includes vegetation and surface cover, tree seedling counts, diameter and counts of overstory trees, canopy closure, and frequency of exotic species.
DOI: 10.17630/39eac936-f4f0-4245-a247-7a9ff44c8e21
title: Avoided metallicity in a hole-doped Mott insulator on a triangular lattice (dataset)
DOI: 10.5281/zenodo.13913178
title: Monsoon-driven intra-seasonal variations in the thermal regime  of a Himalayan proglacial lake
DOI: 10.5281/zenodo.13913179
title: Monsoon-driven intra-seasonal variations in the thermal regime  of a Himalayan proglacial lake
DOI: 10.15468/dl.bggj32
title: Occurrence Download

description: A dataset containing 65354 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (United Kingdom of Great Britain and Northern Ireland, Ireland)",
 "TaxonKey is Oryctolagus cuniculus (Linnaeus, 1758)",
 "Year 2014-2024"
 ]
}

 The dataset includes 65354 records from 80 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006120-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.12770/9b7c48e9-51ae-4c24-a812-d4c551be4fa7
title: HMV 6/7- Complex transcriptomic of OsHV1 infecting C. gigas haemocytes from 0 to 24 hours post contact

description: This dataset consits of 2 experiments HMV6 (initial test, 12 samples) and HMV7 (complete experiment, 48 samples) performing RNAseq on C. gigas pool of haemocytes infected by Ostreid Herpesvirus type 1 accross time.
DOI: 10.15468/dl.jdern5
title: Occurrence Download

description: A dataset containing 26568 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((4.11384 45.55898,4.20202 45.55898,4.20202 45.63109,4.11384 45.63109,4.11384 45.55898))",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 26568 records from 88 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006121-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5518/395
title: Climate model data presented in 'Climatic effect of Antarctic meltwater overwhelmed by concurrent Northern hemispheric melt'

description: This figure from Climatic Effect of Antarctic Meltwater Overwhelmed by Concurrent Northern Hemispheric Melt shows simulated surface air temperature anomalies from background (14.8 ka).  The underlying data is available as 5 discrete datasets from the 'Related resources' links or from the Collection link at the top of this record.
DOI: 10.15468/dl.ttqt6w
title: Occurrence Download

description: A dataset containing 3567 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pheugopedius eisenmanni (T.A.Parker & O'Neill, 1985)"
 ]
}

 The dataset includes 3567 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006122-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.53nka2
title: Occurrence Download

description: A dataset containing 247 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Element content, bulk density, and pH in living and dead wood of 8 tree species in a mesic broad-leaved forest in the East European Plain"
 ]
}

 The dataset includes 247 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006123-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17630/2b19235c-3e05-4398-b74e-9dda08ff6840
title: Data from: The role of condition on sexual selection in the seed bug Lygaeus simulans

description: Data set for the publication:
Balfour, V.L., Corliss, M.K. and Shuker, D.M. (2024). The role of condition on sexual selection in the seed bug Lygaeus simulans. Ecology and Evolution.