cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2008.1745
title: Synthesis of isoquinoline alkaloids from barakol

description: Barakol, cassiarins A and B are biological active compounds extracted from leaves of Cassia siamea. Barakol, with an unprecedented tricyclic core structure similar to cassiarins A and B, is a major constituent in leaves of Cassia siamea. Cassiarins A and B, which have been known to exhibit potent antiplasmodial activity against Plasmodium falciparum, could be extract from the natural source in low yield. Therefore, transformation of barakol to its bioactive isoquinoline alkaloids as cassiarins A and B has been investigated. Synthesis of cassiarin A started from a conversion of barakol to its more stable anhydrobarakol chloride, followed by a reaction with ammonium hydroxide and subsequently reacted with acid to form the cassiarin A. Similarly, cassiarin B and its derivative bearing different N-substituents was synthesized by the reaction of anhydrobarakol chloride and methyl-4-aminobutyrate or the other primary amine, such as butylamine, cyclohexylamine, aniline and benzylamine. All new cassiarin derivatives exhibited negative antiplasmodial activity against Plasmodium falciparum and cytotoxic activity against cancer cell.
DOI: 10.14457/cu.the.2008.1746
title: Synthesis of La0.7Sr0.3Fe1-xMxO3 (M=Ni, Cu, A1 and Mn) as anode materials for solid oxide fuel cell

description: The influence of Cu, Ni, Al and Mn doping at the B–site on the structure and properties of the perovskite oxide La0.7Sr0.3FeO3 was studied. These oxides were synthesized by the modified citrate method. The Cu, Al and Mn specimens showed homogeneous and single phase with cubic perovskite structure, except that Ni–doped specimens which showed single phase with tetragonal structure. The doped metals at the Fe site had significant effect on the crystallite size of La0.7Sr0.3FeO3 materials. The increase of doping amounts of Cu, Al and Mn caused a decrease in the crystallite size of La0.7Sr0.3FeO3 species. On the contrary, the crystallite size increased with the amount of Ni substituted at the Fe site. Reduction property was determined by Temperature–Programmed Reduction (TPR) technique. The result showed that the reduction process increased with the B site metal doping. The conductivity of La0.7Sr0.3FeO3 species was improved by Cu and Ni doping, especially 30% Ni doping that was the most effective quantity for enhancing the electrical conductivity of La0.7Sr0.3FeO3. At 750°C, the conductivity of La0.7Sr0.3Fe0.7Ni0.3O3 (650.5 S/cm) was about 3.8 times higher than that of undoped La0.7Sr0.3FeO3 (170 S/cm). In addition, thermal expansion coefficient of Ni-doped specimens increased with increasing Ni contents.
DOI: 10.14457/cu.the.2008.1747
title: Use of Antisense Morpholino Oligonuckeotides in correction of a novel splicing defect the BTK gene causing Bruton agammaglobulinemia

description: X-linked agammaglobulinemia (XLA) is an inherited primary humoral immunodeficiency characterized by a profound deficiency of all immunoglobulins, mature B cells and plasma cells. XLA is caused by mutations in the Bruton tyrosine kinase (BTK) gene. We studied six patients with clinically diagnosed XLA. Five BTK mutations were identified; three of which were novel and two were known mutations. One of them was an intronic point mutation, a C&gt;A mutation in intron 3 of the BTK gene (c.240+109 C&gt;A). Interestingly, its pathogenicity was evidenced by the presence of aberrant splicing of BTK mRNA, in which there was a 106-bp insertion between exons 3 and 4 resulting in a frameshift. Treatment of cultured peripheral blood mononuclear cells (PBMCs) from the patient with this splicing defect with Antisense Morpholino Oligonucleotides (AMOs) complementary to the mutation splice site sequence was performed. The AMOs were able to restore correctly spliced mRNA in the patient’s PBMCs. Using various concentrations of AMOs, the minimal level with maximal effect in correcting aberrant splicing of the BTK gene in the patient’s PBMCs was about 10 μM. The products of correctly spliced mRNA persisted for up to 30 days after AMOs administration. This approach in which AMOs are used to restore correct splicing of the target gene may be applicable to other splicing mutations and is of potential clinical interest.
DOI: 10.17632/s72swtyf4t.1
title: Data for: Factor Decomposition of China’s Industrial Electricity Consumption Using Structural Decomposition Analysis
DOI: 10.14457/cu.the.2008.1748
title: Formulation and evaluation of facial patch containing phyllanthus emblica extract nanoliposomes

description: Phyllanthus emblica L. (P. emblica) was known as mak-kham-pom in Thailand and it was in Euphorbiaceae family. Firstly, it has been used as the medicinal plant in India because it has many benefits in biological effects including anti-oxidant activity, anti-tyrosinase activity, anti-microbial activity and protection against radiation-induced chromosome damage. In this study, different ratios of soybean phosphatidylcholine (SPC) to Tween®80 of liposomal membrane were formulated and the best formula that gives the highest percent encapsulation efficiency of P. emblica extract was selected to be an active ingredient for preparing the facial patch. The highest percent encapsulation efficiency was 50.56% obtained from nanoliposome formulation in the ratio of 5:1 SPC: Tween®80 containing 1% w/v of P. emblica extract with the mean particle sizes of 566.67+43.50 nm. The facial patch containing P. emblica extract nanoliposomes was developed. The backing layer of the facial patch composed of 2.5% w/v PVA as a film forming agent and the plasticizer was 1% w/v glycerin. The active ingredient was 1% P. emblica extract nanoliposomes. This facial patch provided the most satisfactory mechanical properties of 40.30±4.32 MPa tensile strength, 37.32±5.31% elongation, 246.10±12.21 MPa Young’s modulus, and 2.13±2.3 MJ work of failure, the physical appearance of thin film was transparent. In the diffusion study, more than 99% P. emblica extract was released from nanoliposomes in facial patch within 6 hours. Clinical tests of moisturizing and elasticity were performed in 21 volunteers using Skin Diagnostic SD 27 and DermaLab® Elasticity probe instrument to measure moisture content and elasticity on the forehead area. The moisture contents were increased and Young’s modulus were significantly decreased (p &lt; 0.05) resulted in the improvement of elasticity of the skin after 4 weeks of application. Macroscopic photograph was also taken to evaluate and corresponded to these results.
DOI: 10.14457/cu.the.2008.1749
title: Effects of Glutathione on relaxation of the isolated rat aorta

description: It has been reported that depletion of GSH affected the function of vascular system, including control of vascular tone. This study investigated the direct effects of GSH on vascular tension, using the in vitro model of isolated rat thoracic aorta. The results showed that GSH significantly induced both endothelium-dependent and endothelium-independent relaxation of aortic preparations which were precontracted with PE. However, the presence of endothelium influenced the response of aortic muscles toward treatment of GSH, resulting in the difference of the characteristic of the tracing profiles and degree of relaxation. The endothelium-dependent relaxation were abolished by pretreatment with L-NAME, methylene blue and glibenclamide whereas the endothelium-independent relaxation were reduced only by pretreatment with glibenclamide. Therefore, the mechanisms of GSH-induced relaxation involved the NOcGMP pathway as well as membrane hyperpolarization pathway. Moreover, extracellular Ca2+ could also determine the effects of GSH on vasorelaxation because the presence of EGTA, but not BAPTA-AM, could interfere the vasorelaxation. In addition, GSH was able to enhance the effects of Ach, but not SNP on vasorelaxation. Hence, it was likely that GSH enhanced the production of NO via increasing Ca2+ influx in endothelium cell, but had no effect on the production of cGMP in vascular smooth muscle cell. Furthermore, GSH was able to directly inhibit the contraction of smooth muscle in certain conditions. The results showed that GSH could elicit its inhibitory action toward the contraction induced by PE, 5-HT and histamine but not those induced by KCl, TEA and PMA. In addition, GSH also inhibited the Ca2+ influx in high K+-depolarizing solution. Thus, these findings suggested that GSH modulated the vascular tone via interference of Ca2+ influx through membrane Ca2+ channels on vascular smooth cells. Moreover, GSH could partially interfere Ca2+-release from internal storage which coupled to IP3 signaling. Taken together, GSH could directly modulate the control of vascular tone by enhance the NO-cGMP pathway in endothelium cells as well as disrupt the Ca2+ influx and Ca2+- release in the smooth muscle cells.
DOI: 10.14457/cu.the.2008.1750
title: Computer adaptive assessment tool for monitorng the use of high cost drugs in civil servant medical beneftt scheme

description: Objectives of this study were to develop computer adaptive assessment tool (CAAT) for monitoring the use of high cost drugs (HCDs) in Civil Servant Medical Benefit Scheme (CSMBS), to validate CAAT, and to evaluate the use of HCDs in CSMBS concerning pharmaceutical spending and rational utilization. Retrospective review of CSMBS outpatients initiating Atorvastatin and Rosiglitazone during November 2006 and April 2007 was conducted. The documentation review for CAAT algorithm and the analysis of data from electronic dispensing, laboratory, and ICD-10 database were employed for CAAT development. To validate CAAT, the results from CAAT analysis were compared with the results from conventional drug use evaluation. Rational use of HCDs and their expense were evaluated by using the developed CAAT. The results revealed that the development of CAAT algorithm and the data management were essential elements. CAAT guidelines development, selecting key variables and their cut points were needed for CAAT algorithm development. Data extraction, data linkage (data relation) and data completeness were required for data management. When validating CAAT for Atorvastatin, its sensitivity, specificity and accuracy were 81.3%, 100.0%, and 98.0% respectively. For Rosiglitazone, its sensitivity, specificity, and accuracy of CAAT were 82.3%, 100.0%, and 95.9% respectively. Using CAAT to evaluate rational use based on pattern analysis, Atorvastatin use of 76 (13.0%) patients from four regional hospitals and Rosiglitazone use of 15 (17.2%) patients from two hospitals were rational. It was found that 15.0% (448,500 baht) of Atorvastatin’s expenditure and 15.3% (94,500 baht) of Rosiglitazone’s expenditure were rational. In conclusion, CAAT can be applied for monitoring the use of HCDs efficiently. Finding of only 15% of expenditure of Atorvastatin and Rosiglitazone that were rational indicated the need for the improvement of HCD’s prescribing pattern. It was recommended that assessing acceptability and applicability of using CAAT for monitoring HCD use among health care providers and assessing policy acceptance of the Comptroller’s General Department are needed for further study. In addition, the national coding system of drugs, laboratory, and patient characteristics should be established.
DOI: 10.14457/cu.the.2008.1751
title: Cost analysis of the disability victims by alcohol drunk driving from traffic accident:a case study in bangkok

description: The aim of this study would like to analyze the total cost which affect to the household costs of disability victims and their relatives by alcohol drunk driving from traffic accident in Bangkok in first year of treatment (in term of patient’s and their relatives point of view). This descriptive cross sectional study collect the data by using secondary data by questionnaires, select the sample from Don’t Drive Drunk foundation members by 95 samples. The cost of disability victims by drunk driving from traffic accident can be divided into patient cost and patient’s relative cost and both have direct and indirect for calculation by cost analysis. Costs was separately in each diagnosis related group and summaries again for the result as total cost per one person in first year after patient accident (total of all 25 cost components). The result of this study found that the cost of the disability victims by alcohol drunk driving from traffic accident in Bangkok in first year after patient’s accident(only patient’s cost)are 603,235.52 Baht/person in first year after patient’s accident ,The cost of the disability victims’s relatives by alcohol drunk driving from traffic accident in Bangkok in first year after patient’s accident are 612,682.54 Baht/person in first year after patient’s accident and Total Cost of the disability victims by alcohol drunk drivers from traffic accident : A case study in Bangkok from the result of this study by summarizes of all cost components is 1,215,918.06 Baht/person in 1st year of patient’s accident. According to the result of regression analysis in the study. It may explain the factors that affecting to the total cost of disability victims by drunk driving from traffic accident : A case study in Bangkok which make the cost become higher or lower depends on 2 significant variables ,there’re Patient’s income before accident per person per month ,Relative’s income before patient’s accident per person per month. This study provides more about the basic information of disability victims by drunk driving from traffic accident for people who are interested in also to the administration of government sectors in order to plan and control the budget or launch policy and specify the proper policy to help and support the disability victims by drunk driving from traffic accident more patient.
DOI: 10.14457/cu.the.2008.1752
title: Cross - Resistance between an Antiseptic Halquinol and Antibiotics in Escherichia coli Isolated from Swine

description: A total of 355 Escherichia coli isolates from swine were comprising of group I, non Halquinol-exposed E. coli isolates (n=203) and group II, Halquinol-exposed E. coli isolates (n=152). All samples were assayed for usceptibility to Halquinol and 8 antibiotics. Two antibiotic-susceptible E. coli isolates with low Halquinol MIC and E.coli MG1655rifr were used for Halquinol-exposure experiment. Nineteen of the E. coli isolates from group II that exhibited high Halquinol MIC and contained plasmid were assessed for transfer of Haquinol resistance. Most of E. coli in group I (69.1%) exhibited Halquinol MIC of 32-64 ug/ml. The E. coli isolates in group ll formed a large population (86.7%) with Halquinol MIC range 4-64 ug/ml and a frequency peak at MIC of 128 ug/ml (11.8%). The Halquinol MIC90 of E. coli in group I and II were 64 and 128 ug/ml, respectively. Resistance rates to al antibiotics (except trimethoprim) of E. coli in group I were significantly greater than that of E.coli in group II (p&lt;0.05). Most of the E. coli isolates from both groups were multiresistant. Forty-one resistance patterns were defined and the most commnon resistance pattern (16%) wa ampicillin-chloramphenicol-ciprofloxacn-gentamicin-streptomycin-sulfomethoxazole-tetracycline. No spontaneous Halquinol-resistant mutants were obtained and no cross-resistance to antibiotics was observed. Halquinol resistance was not horizontally transferred.
DOI: 10.14457/cu.the.2008.1753
title: Curl forecasting for paper quality in papermaking industry

description: This thesis presents a quality-forecasting model based on neural network for the paper making industry with different source data transaction processes. The paper quality test and control plays an essential role in the paper making industry, which affects the whole operation process and the future paper market. Compared with other paper quality indexes, paper curl is closer to terminal clients and more difficult to pretest and control in the actual working environment. Large-scale data from production database, which would potentially affect final paper quality, have been cleansed and abstracted. Modeling based on MLP neural network was designed to compare between Quasi-Newton algorithm and Double Dogleg with early stopping regularization in different source data sets. With bootstrap accuracy estimation, the final result has been evolved which would annotate the relationship between workflow data and paper curvature in a more constructive way.
DOI: 10.14457/cu.the.2008.1754
title: Dark fermentative biohydrogen production from brewery wastes

description: Since brewery waste yeast is plenty and contains high nutritional value, the possibility in using for enhancing H[subscript 2] production is studied. The two sets of batch experimental set-up were carried out in CSTR operating at pH and temperature of 5.0 and 30 ํC, respectively, by means of brewery waste yeast adding and non-waste yeast adding using glucose as substrate. Factorial design experiments with a central composite design (CCD) and response surface methodology (RSM) were used for finding optimal point of glucose, brewery waste yeast and microbial sludge concentration that yielded the maximum hydrogen production rate. For explanation process reaction and design, the Monod kinetic coefficient rate of k and Ks were determined using the integrated Monod equation weighted least-square model. The modified Gompertz equation could be used to best fit the accumulative hydrogen production with correlation (R[superscript 2]) greater than 0.98. It was shown that at 7.0 g/l glucose, 11 g/l brewery waste yeast and 12 g/l of microbial sludge, the highest H[subscript 2] yield of 1.42 mol H[subscript 2]/mol glucose was obtained. Addition of brewery waste yeast into synthetic wastewater in the reactor was found to shift the specific H[subscript 2] production rate from 2.5 to 3.9 ml H[subscript 2]/g VSS.h[superscript -1]. The apparent kinetic value of k (maximum specific substrate utilization rate) was also shift from 0.52 to 1.84 d[superscript -1]. The effect of hydraulic retention time (HRT) on continuous H[subscript 2] production and its mixed anaerobic microbial community were observed in a CSTR operated with 4 HRTs, each lasting 10 days. The major bacterial composition of each HRT was analyzed by 16S rRNA gene-targeted denaturing gradient gel electrophoresis (DGGE). It was found that the H[subscript 2] production was increased after transition from 24h, 12h, 8h and 4h HRT. The experimental result clearly showed that H[subscript 2] yield as high as 2.87 mol H[subscript 2]/mol glucose was achieved at 4h HRT running, corresponding to 71.8% H[subscript 2] conversion efficiency compared to the theoretical yield. Clostridium pasteurianum sp. and uncultured bacterium Clone HPR 146 existed in the reactor might be the dominant strains that contribute to H[subscript 2] production at HRT 4h.
DOI: 10.14457/cu.the.2008.1755
title: Decolorization of molasses wastewater from distilleries using bacterial consortium

description: Distillery effluent from sugarcane molasses leads to an environmental pollution due to its large volume and the presence of dark brown colored compounds, known as melanoidins. In this study, a bacterial consortium CONS8 isolated from waterfall sediments in Maehongsorn province was selected as a molasses-decolorizing consortium. Consortium CONS8 was able to decolorize, only within 2 days, in Erlenmeyer flasks, three different synthetic wastewaters containing either Viandox sauce (13.5% v/v), beet molasses wastewater (41.5% v/v) or sugarcane molasses wastewater (20% v/v) at 9.5, 8.0 and 17.5%, respectively. Four predominant bacteria present in the consortium CONS8 were identified by the 16S rDNA analysis. To achieve the highest decolorization, the artificial bacterial consortium MMP1 comprising Klebsiella oxytoca, Serratia mercescens (T2) and unknown bacterium DQ817737 (T4), was constructed. Under optimized conditions (aeration, pH), the bacterial consortium MMP1 was able to decolorize the synthetic melanoidins-containing wastewater at 18.3% within 2 days. The comparison of decolorization by the consortium MMP1 with abiotic control proved that the color removal for synthetic melanoidins-containing wastewater medium was mainly due to biotic activity of bacterial cells, without any adsorption phenomena. Supplement of nutrients and vitamin B did not promote melanoidins decolorization by bacterial consortium MMP1. Finally, the performance of a membrane bioreactor (MBR) for synthetic melanoidins-containing wastewater treatment was investigated at laboratory scale, with a mineral membrane. The reactor seeding was made with the MMP1 bacterial consortium inoculum. The reactor was performed with several hydraulic retention times (HRT) of 15, 20, and 40 hours. The performances were analyzed in terms of COD, color removal and biomass in the reactor. The results indicated that the higher COD and color removal efficiency were achieved with the longer HRT.
DOI: 10.14457/cu.the.2008.1756
title: Degradation of O-toluidine by fenton processes

description: o-toluidine (OT) is an important aromatic amines that used in the dyestuffs industry and more recently in the rubber industry. OT can be found in several wastewaters and is associated with an increased incidence of bladder cancer. This study investigated the degradation and detoxification of OT by several Fenton processes. In the Design-Expert software, factorial design (24) approach was used for the selection of significant parameters after that the Box-Benhken response surface function was used for optimization of degradation conditions for OT and COD removals by electro-Fenton process. The amount of Fe2+ (0.2-1.0 mM) and H2O2 (1-5 mM), pH (2-4), and current (1-4 A) were selected as independent variables while OT and COD removal efficiency were considered as the response functions. The pH, Fe2+ and H2O2 concentrations were found to be the key parameters and; hence were used to find the optimum condition with constant current of 1 A. The model suggestion for the selected condition for OT oxidation, at pH 2, 1 mM of Fe2+, 4.85 mM of H2O2 and 1 A of constant current, would provide 91% and 41% removal for OT and COD, respectively. Experimental results revealed that 1 mM of OT could be removed completely within 90 and 60 minutes by electro-Fenton and photoelectro-Fenton processes, respectively. COD abatement by ordinary, electro- and photoelectro-Fenton processes were 36%, 50% and 52%, respectively. The OT oxidation was a two-step process; hence, characterized separately by using zero-order kinetics for the initial stage and first-order kinetics for the second stage. The initial rate constants for OT oxidation were 0.369, 0.384 and 0.389 mMmin-1 where as the second-stage, first-order rate constants were 0.0124, 0.0356 and 0.0572 min-1 for ordinary, electro- and photoelectro-Fenton processes, respectively. Electro- and photoelectro-Fenton processes could effectively detoxify the OT better than the ordinary Fenton, i.e., the BOD5:COD ratio increased from 0.125 of the ordinary Fenton to 0.289 and 0.357 for electro- and photoelectro-Fenton processes, respectively. Maleic and oxalic acids were identified as the intermediates of OT oxidation by hydroxyl radicals.