cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25345/c5xx87
title: MassIVE MSV000085995 - Peptide profiling of laser microdissected human trophoblast subtypes during the second trimester
title: Human placental architecture is complex. Its surface epithelium, specialized for transport, forms by fusion of cytotrophoblast progenitors into multinucleated syncytiotrophoblasts. Near the uterine surface, these progenitors assume a different fate, becoming cancer like cells that invade its lining and blood vessels. The latter process physically connects the placenta to the mother and shunts uterine blood to the syncytiotrophoblasts. Isolation of trophoblast subtypes is technically challenging. Upon removal, syncytiotrophoblasts disintegrate and invasive cytotrophoblasts are admixed with uterine cells. We used laser capture to circumvent these obstacles. This enabled isolation of syncytiotrophoblasts and two subpopulations of invasive cytotrophoblasts; cell column and endovascular. Transcriptional profiling revealed numerous genes whose placental or trophoblast expression was not known, including neurotensin and C4ORF36. Using mass spectrometry, discovery of differentially expressed mRNAs was extended to the protein level. We also found that invasive cytotrophoblasts expressed cannabinoid receptor 1. Unexpectedly, screening agonists and antagonists showed signals from this receptor promote invasion. Together these results revealed novel gene expression patterns that translate to the protein level. Our data also suggested that endogenous and exogenous cannabinoids can affect human placental development.
DOI: 10.6084/m9.figshare.12838073.v2
title: GeophysicalResearchLettersData.xlsx

description: The original data for Figures in recently accepted manuscript entitled "In-situ investigations of dust above the lunar terminator at the Chang’E-3 landing site in the Mare Imbrium<br>" for GRL.
DOI: 10.6084/m9.figshare.12838073.v1
title: GeophysicalResearchLettersData.xlsx

description: The original data for Figures in recently accepted manuscript entitled "In-situ investigations of dust above the lunar terminator at the Chang’E-3 landing site in the Mare Imbrium<br>" for GRL.
DOI: 10.6084/m9.figshare.12845180.v1
title: GeophysicalResearchLettersData.xlsx

description: The original data for Figures in recently accepted manuscript entitled "In-situ investigations of dust above the lunar terminator at the Chang’E-3 landing site in the Mare Imbrium<br>" for GRL.
DOI: 10.6084/m9.figshare.12845243
title: Accounting for overdispersion of lethal lesions in the linear quadratic model improves performance at both high and low radiation doses

description: <b>Purpose:</b> The linear-quadratic (LQ) model represents a simple and robust approximation for many mechanistically-motivated models of radiation effects. We believe its tendency to overestimate cell killing at high doses derives from the usual assumption that radiogenic lesions are distributed according to Poisson statistics. <b>Materials and methods:</b> In that context, we investigated the effects of overdispersed lesion distributions, such as might occur from considerations of microdosimetric energy deposition patterns, differences in DNA damage complexities and repair pathways, and/or heterogeneity of cell responses to radiation. Such overdispersion has the potential to reduce dose response curvature at high doses, while still retaining LQ dose dependence in terms of the number of <i>mean</i> lethal lesions per cell. Here we analyze several irradiated mammalian cell and yeast survival data sets, using the LQ model with Poisson errors, two LQ model variants with customized negative binomial (NB) error distributions, the Padé-linear-quadratic, and Two-component models. We compared the performances of all models on each data set by information-theoretic analysis, and assessed the ability of each to predict survival at high doses, based on fits to low/intermediate doses. <b>Results:</b> Changing the error distribution, while keeping the LQ dose dependence for the mean, enables the NB LQ model variants to outperform the standard LQ model, often providing better fits to experimental data than alternative models. <b>Conclusions:</b> The NB error distribution approach maintains the core mechanistic assumptions of the LQ formalism, while providing superior estimates of cell survival following high doses used in radiotherapy. Importantly, it could also be useful in improving the predictions of low dose/dose rate effects that are of major concern to the field of radiation protection.
DOI: 10.7910/dvn/rkcm19/xlpraa
title: The-Curve-Not-Taken_R_Markdown.html

description: :unav
DOI: 10.6084/m9.figshare.12845180
title: GeophysicalResearchLettersData.xlsx

description: The original data for Figures in recently accepted manuscript entitled "In-situ investigations of dust above the lunar terminator at the Chang’E-3 landing site in the Mare Imbrium<br>" for GRL.
DOI: 10.6084/m9.figshare.12845243.v1
title: Accounting for overdispersion of lethal lesions in the linear quadratic model improves performance at both high and low radiation doses

description: <b>Purpose:</b> The linear-quadratic (LQ) model represents a simple and robust approximation for many mechanistically-motivated models of radiation effects. We believe its tendency to overestimate cell killing at high doses derives from the usual assumption that radiogenic lesions are distributed according to Poisson statistics. <b>Materials and methods:</b> In that context, we investigated the effects of overdispersed lesion distributions, such as might occur from considerations of microdosimetric energy deposition patterns, differences in DNA damage complexities and repair pathways, and/or heterogeneity of cell responses to radiation. Such overdispersion has the potential to reduce dose response curvature at high doses, while still retaining LQ dose dependence in terms of the number of <i>mean</i> lethal lesions per cell. Here we analyze several irradiated mammalian cell and yeast survival data sets, using the LQ model with Poisson errors, two LQ model variants with customized negative binomial (NB) error distributions, the Padé-linear-quadratic, and Two-component models. We compared the performances of all models on each data set by information-theoretic analysis, and assessed the ability of each to predict survival at high doses, based on fits to low/intermediate doses. <b>Results:</b> Changing the error distribution, while keeping the LQ dose dependence for the mean, enables the NB LQ model variants to outperform the standard LQ model, often providing better fits to experimental data than alternative models. <b>Conclusions:</b> The NB error distribution approach maintains the core mechanistic assumptions of the LQ formalism, while providing superior estimates of cell survival following high doses used in radiotherapy. Importantly, it could also be useful in improving the predictions of low dose/dose rate effects that are of major concern to the field of radiation protection.
DOI: 10.6084/m9.figshare.12845168
title: Educação a distância e a integração das tecnologias na educação.pdf

description: A internet, com as interfaces, como a Web 2.0, veio representar uma segunda geração da Web, mais aprimorada, que potencializa a colaboração e a disseminação de conhecimentos e conteúdos entre as pessoas. Interligados por tecnologias, principalmente as telemáticas, Educação a Distância é ensino-aprendizagem onde professores e alunos estão separados espacial e/ou temporalmente. É de suma importância, portanto, possibilitar a todos o acesso às tecnologias, à informação significativa e à mediação de professores preparados para a sua utilização.The Internet, with interfaces such as Web 2.0, has come to represent a second generation of the most improved Web, which enhances collaboration and dissemination of knowledge and content among people. Interconnected by technologies, especially telematics, Distance Education is teaching and learning where teachers and students are separated spatially and/or temporally. It is therefore of paramount importance to enable everyone to access technologies, meaningful information and the mediation of teachers prepared for their use.<br>
DOI: 10.6084/m9.figshare.12845168.v1
title: Educação a distância e a integração das tecnologias na educação.pdf

description: A internet, com as interfaces, como a Web 2.0, veio representar uma segunda geração da Web, mais aprimorada, que potencializa a colaboração e a disseminação de conhecimentos e conteúdos entre as pessoas. Interligados por tecnologias, principalmente as telemáticas, Educação a Distância é ensino-aprendizagem onde professores e alunos estão separados espacial e/ou temporalmente. É de suma importância, portanto, possibilitar a todos o acesso às tecnologias, à informação significativa e à mediação de professores preparados para a sua utilização.The Internet, with interfaces such as Web 2.0, has come to represent a second generation of the most improved Web, which enhances collaboration and dissemination of knowledge and content among people. Interconnected by technologies, especially telematics, Distance Education is teaching and learning where teachers and students are separated spatially and/or temporally. It is therefore of paramount importance to enable everyone to access technologies, meaningful information and the mediation of teachers prepared for their use.<br>
DOI: 10.6084/m9.figshare.12845294
title: Diagnostic accuracy of procalcitonin for bacterial pneumonia in children – a systematic review and meta-analysis

description: <b>Objective:</b> The predictive role of procalcitonin for childhood bacterial pneumonia, a leading cause of death, is unclear. We aimed to evaluate the diagnostic accuracy of procalcitonin for childhood bacterial pneumonia. <b>Methods:</b> Major bibliographic databases were searched from inception through September 2019 using pre-defined index terms, including ‘procalcitonin,’ ‘pneumonia’ and ‘children’. The study is reported according to <i>Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies</i>. Meta-analyses of the diagnostic accuracy and odds ratio of procalcitonin for bacterial pneumonia were conducted along with subgroup analyses for different cut-offs of procalcitonin. <i>The Quality Assessment of Diagnostic Accuracy Studies 2</i> instrument was used to assess the methodologic quality of eligible studies. <b>Results:</b> Twenty-five studies (with 2,864 patients) showed that procalcitonin for bacterial pneumonia had an overall sensitivity of 0.64 (95% confidence interval: 0.53–0.74), specificity of 0.72 (95% confidence interval: 0.64–0.79), positive likelihood ratio of 2.3 (95% confidence interval: 1.8–3.0) and negative likelihood ratio of 0.50 (95% confidence interval: 0.38–0.66), and Area Under the Receiver Operating Characteristics of 0.74 (95% confidence interval: 0.70–0.78). Using a cut-off of 0.5 ng/ml, Procalcitonin had a sensitivity of 0.68 (95% confidence interval: 0.50–0.82), specificity of 0.60 (95% confidence interval: 0.47–0.72), and Area Under the Receiver Operating Characteristics of 0.68 (95% confidence interval: 0.64–0.72). Using a cut-off of 2 ng/ml, procalcitonin had a sensitivity of 0.59 (95% confidence interval: 0.40–0.76), specificity of 0.71 (95% confidence interval: 0.58–0.81), and AUROC curve of 0.71 (95% confidence interval: 0.67–0.75). Elevated procalcitonin was not associated with increased odds of bacterial pneumonia (odds ratio: 1.36, 95% confidence interval: 0.81–1.92, <i>p</i> = .18). Quality assessment found minimal concerns for bias or applicability. <b>Conclusions:</b> Given the moderate diagnostic accuracy of procalcitonin for bacterial pneumonia, we recommend that procalcitonin be used in conjunction with other findings for management and disposition of children with pneumonia.
DOI: 10.6084/m9.figshare.12845294.v1
title: Diagnostic accuracy of procalcitonin for bacterial pneumonia in children – a systematic review and meta-analysis

description: <b>Objective:</b> The predictive role of procalcitonin for childhood bacterial pneumonia, a leading cause of death, is unclear. We aimed to evaluate the diagnostic accuracy of procalcitonin for childhood bacterial pneumonia. <b>Methods:</b> Major bibliographic databases were searched from inception through September 2019 using pre-defined index terms, including ‘procalcitonin,’ ‘pneumonia’ and ‘children’. The study is reported according to <i>Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies</i>. Meta-analyses of the diagnostic accuracy and odds ratio of procalcitonin for bacterial pneumonia were conducted along with subgroup analyses for different cut-offs of procalcitonin. <i>The Quality Assessment of Diagnostic Accuracy Studies 2</i> instrument was used to assess the methodologic quality of eligible studies. <b>Results:</b> Twenty-five studies (with 2,864 patients) showed that procalcitonin for bacterial pneumonia had an overall sensitivity of 0.64 (95% confidence interval: 0.53–0.74), specificity of 0.72 (95% confidence interval: 0.64–0.79), positive likelihood ratio of 2.3 (95% confidence interval: 1.8–3.0) and negative likelihood ratio of 0.50 (95% confidence interval: 0.38–0.66), and Area Under the Receiver Operating Characteristics of 0.74 (95% confidence interval: 0.70–0.78). Using a cut-off of 0.5 ng/ml, Procalcitonin had a sensitivity of 0.68 (95% confidence interval: 0.50–0.82), specificity of 0.60 (95% confidence interval: 0.47–0.72), and Area Under the Receiver Operating Characteristics of 0.68 (95% confidence interval: 0.64–0.72). Using a cut-off of 2 ng/ml, procalcitonin had a sensitivity of 0.59 (95% confidence interval: 0.40–0.76), specificity of 0.71 (95% confidence interval: 0.58–0.81), and AUROC curve of 0.71 (95% confidence interval: 0.67–0.75). Elevated procalcitonin was not associated with increased odds of bacterial pneumonia (odds ratio: 1.36, 95% confidence interval: 0.81–1.92, <i>p</i> = .18). Quality assessment found minimal concerns for bias or applicability. <b>Conclusions:</b> Given the moderate diagnostic accuracy of procalcitonin for bacterial pneumonia, we recommend that procalcitonin be used in conjunction with other findings for management and disposition of children with pneumonia.
DOI: 10.5517/ccdc.csd.cc23cd0x
title: CCDC 1947358: Experimental Crystal Structure Determination

description: Related Article: Chenghui Zhang, Huaizhong Shi, Yan Yan, Libo Sun, Yu Ye, Yizhong Lu, Zhiqiang Liang, Jiyang Li|2020|Dalton Trans.|49|10613|doi:10.1039/C9DT04679H
DOI: 10.5517/ccdc.csd.cc2582l4
title: CCDC 2003765: Experimental Crystal Structure Determination

description: Related Article: Hongshan Ke, Yongsheng Yang, Wen Wei, Youdong Jiang, Yi-Quan Zhang, Gang Xie, Sanping Chen|2020|Dalton Trans.|49|10594|doi:10.1039/D0DT02139C
DOI: 10.5517/ccdc.csd.cc24s144
title: CCDC 1989305: Experimental Crystal Structure Determination

description: Related Article: Urooj Iqbal, M. Iqbal Choudhary, Sammer Yousuf|2021|J.Mol.Struct.|1224|128981|doi:10.1016/j.molstruc.2020.128981
DOI: 10.5517/ccdc.csd.cc24s111
title: CCDC 1989302: Experimental Crystal Structure Determination

description: Related Article: Urooj Iqbal, M. Iqbal Choudhary, Sammer Yousuf|2021|J.Mol.Struct.|1224|128981|doi:10.1016/j.molstruc.2020.128981
DOI: 10.5517/ccdc.csd.cc24s100
title: CCDC 1989301: Experimental Crystal Structure Determination

description: Related Article: Urooj Iqbal, M. Iqbal Choudhary, Sammer Yousuf|2021|J.Mol.Struct.|1224|128981|doi:10.1016/j.molstruc.2020.128981
DOI: 10.6084/m9.figshare.8180768
title: Effects of air pollution on moderate and severe asthma exacerbations

description: <b>Background:</b> Few studies have evaluated the impact of air pollution levels on the severity of exacerbations. Thus, we compared the relative risks posed by air pollutant levels on moderate and severe exacerbations. <b>Methods:</b> Exacerbation episodes of 618 from 143 adult asthmatics were retrospectively collected between 2005 and 2015 in a tertiary hospital of Korea. Air pollution GPS data for the location closest to each patient’s home were obtained from the national ambient monitoring station. The relative impacts of air pollutants on asthma exacerbations were evaluated via a time-trend controlled symmetrical, bidirectional, case-crossover design using conditional logistic regression models on the day of the exacerbation (T-0) and up to 3 days before the exacerbation (T-1–T-3). <b>Results:</b> Overall asthma exacerbation were associated with O<sub>3</sub> levels in summer and winter (OR: 1.012[1.003–1.02] and 1.009[1.003–1.016]), SO<sub>2</sub> levels in spring and summer (OR: 1.009[1–1.018] and 1.02[1.006–1.035]) and NO<sub>2</sub> levels in winter (OR: 1.007[1.003–1.011]). Analyses of the temporal relationship between O<sub>3</sub> concentrations and exacerbations demonstrated that 63.2% of episodes in the summer occurred when the O<sub>3</sub> concentrations on T-1 were significantly higher than those on control days, while 51% of exacerbation episodes in the winter occurred. Severe and moderate exacerbations were similarly associated with O<sub>3</sub> levels in winter (OR: 1.012 [1.003–1.02] vs. 1.01 [0.999–1.021], <i>p</i> &gt; 0.05) and in summer (OR: 1.006 [1.002–1.009] vs. 1.009 [1.003–1.016], <i>p</i> &gt; 0.05). <b>Conclusions:</b> Asthma exacerbations may be associated with the seasonal elevation of O<sub>3</sub>, SO<sub>2</sub> and NO<sub>2</sub> levels in summer and winter with the similar relative risk between moderate and severe exacerbations.
DOI: 10.6084/m9.figshare.8180768.v2
title: Effects of air pollution on moderate and severe asthma exacerbations

description: <b>Background:</b> Few studies have evaluated the impact of air pollution levels on the severity of exacerbations. Thus, we compared the relative risks posed by air pollutant levels on moderate and severe exacerbations. <b>Methods:</b> Exacerbation episodes of 618 from 143 adult asthmatics were retrospectively collected between 2005 and 2015 in a tertiary hospital of Korea. Air pollution GPS data for the location closest to each patient’s home were obtained from the national ambient monitoring station. The relative impacts of air pollutants on asthma exacerbations were evaluated via a time-trend controlled symmetrical, bidirectional, case-crossover design using conditional logistic regression models on the day of the exacerbation (T-0) and up to 3 days before the exacerbation (T-1–T-3). <b>Results:</b> Overall asthma exacerbation were associated with O<sub>3</sub> levels in summer and winter (OR: 1.012[1.003–1.02] and 1.009[1.003–1.016]), SO<sub>2</sub> levels in spring and summer (OR: 1.009[1–1.018] and 1.02[1.006–1.035]) and NO<sub>2</sub> levels in winter (OR: 1.007[1.003–1.011]). Analyses of the temporal relationship between O<sub>3</sub> concentrations and exacerbations demonstrated that 63.2% of episodes in the summer occurred when the O<sub>3</sub> concentrations on T-1 were significantly higher than those on control days, while 51% of exacerbation episodes in the winter occurred. Severe and moderate exacerbations were similarly associated with O<sub>3</sub> levels in winter (OR: 1.012 [1.003–1.02] vs. 1.01 [0.999–1.021], <i>p</i> &gt; 0.05) and in summer (OR: 1.006 [1.002–1.009] vs. 1.009 [1.003–1.016], <i>p</i> &gt; 0.05). <b>Conclusions:</b> Asthma exacerbations may be associated with the seasonal elevation of O<sub>3</sub>, SO<sub>2</sub> and NO<sub>2</sub> levels in summer and winter with the similar relative risk between moderate and severe exacerbations.
DOI: 10.6084/m9.figshare.8180768.v1
title: Effects of air pollution on moderate and severe asthma exacerbations

description: <b>Background:</b> Few studies have evaluated the impact of air pollution levels on the severity of exacerbations. Thus, we compared the relative risks posed by air pollutant levels on moderate and severe exacerbations. <b>Methods:</b> Exacerbation episodes of 618 from 143 adult asthmatics were retrospectively collected between 2005 and 2015 in a tertiary hospital of Korea. Air pollution GPS data for the location closest to each patient’s home were obtained from the national ambient monitoring station. The relative impacts of air pollutants on asthma exacerbations were evaluated via a time-trend controlled symmetrical, bidirectional, case-crossover design using conditional logistic regression models on the day of the exacerbation (T-0) and up to 3 days before the exacerbation (T-1–T-3). <b>Results:</b> Overall asthma exacerbation were associated with O<sub>3</sub> levels in summer and winter (OR: 1.012[1.003–1.02] and 1.009[1.003–1.016]), SO<sub>2</sub> levels in spring and summer (OR: 1.009[1–1.018] and 1.02[1.006–1.035]) and NO<sub>2</sub> levels in winter (OR: 1.007[1.003–1.011]). Analyses of the temporal relationship between O<sub>3</sub> concentrations and exacerbations demonstrated that 63.2% of episodes in the summer occurred when the O<sub>3</sub> concentrations on T-1 were significantly higher than those on control days, while 51% of exacerbation episodes in the winter occurred. Severe and moderate exacerbations were similarly associated with O<sub>3</sub> levels in winter (OR: 1.012 [1.003–1.02] vs. 1.01 [0.999–1.021], <i>p</i> &gt; 0.05) and in summer (OR: 1.006 [1.002–1.009] vs. 1.009 [1.003–1.016], <i>p</i> &gt; 0.05). <b>Conclusions:</b> Asthma exacerbations may be associated with the seasonal elevation of O<sub>3</sub>, SO<sub>2</sub> and NO<sub>2</sub> levels in summer and winter with the similar relative risk between moderate and severe exacerbations.
DOI: 10.5281/zenodo.3941420
title: Data in the western equatorial Pacific

description: This dataset contains microstructure, temperature, salinity, and shear data. Microstructure data were obtained with an expendable Vertical Microstructure Profiler (VMP-X, Rockland Scientific Inc.). Fine-structure temperature and salinity data were collected using a Seabird 9-11 Plus CTD. Fine-structure shear data was collected using two lowered acoustic Doppler current profilers.
DOI: 10.5281/zenodo.3464263
title: Data in the western equatorial Pacific

description: This dataset contains microstructure, temperature, salinity, and shear data. Microstructure data were obtained with an expendable Vertical Microstructure Profiler (VMP-X, Rockland Scientific Inc.). Fine-structure temperature and salinity data were collected using a Seabird 9-11 Plus CTD. Fine-structure shear data was collected using two lowered acoustic Doppler current profilers.
DOI: 10.6084/m9.figshare.12844400
title: R0187_20170928a_videos

description: Rat 0187, skilled reaching data collected on 9/28/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12844400.v1
title: R0187_20170928a_videos

description: Rat 0187, skilled reaching data collected on 9/28/2017 in Leventhal laboratory by Alexandra Bova
DOI: 10.6084/m9.figshare.12845285
title: Dispositivos móveis no contexto educacional.pdf

description: O objetivo deste trabalho é investigar como os dispositivos móveis podem ser utilizados por professores de ensino superior em sala de aula. Trata também da adaptação da biblioteca a um modelo que incorpore as novas Tecnologias Digitais de Informação e Comunicação (TDIC) no seu cotidiano, para melhor atender alunos da Universidade. Sinaliza a necessidade de uma reflexão sobre essa nova escola, os papéis dos estudantes, docentes, bibliotecários e gestores das bibliotecas para que haja inclusão digital e informacional, frente a essa nova realidade.The objective of this work is to investigate how mobile devices can be used by higher education teachers in the classroom. It also deals with the adaptation of the library to a model that incorporates the new Digital Information and Communication Technologies (TDIC) in their daily lives, in order to better serve students of the University. It signals the need for a reflection on this new school, the roles of students, teachers, librarians and library managers so that there is digital and informational inclusion, in the face of this new reality.<br>