cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.58119/ulg/uowrsl/gvceyo
title: gFr-mp-13948-valence.dat

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DOI: 10.58119/ulg/uowrsl/skqv3c
title: mp-540957-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/oluof0
title: mp-574599-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/lotamy
title: mp-8751-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/qyp00q
title: mp-2286-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/mtej61
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DOI: 10.58119/ulg/uowrsl/jt7ke7
title: mp-15557-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/dv5mas
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DOI: 10.58119/ulg/uowrsl/24ol45
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DOI: 10.58119/ulg/uowrsl/ocsxuc
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DOI: 10.58119/ulg/uowrsl/3kxhti
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DOI: 10.58119/ulg/uowrsl/2vrjwk
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DOI: 10.58119/ulg/uowrsl/p0iibu
title: mp-13056-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/rv2oqt
title: gFr-mp-773137-valence.dat

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DOI: 10.58119/ulg/uowrsl/alhelb
title: mp-547244-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/sgvbut
title: gFr-mp-4175-valence.dat

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DOI: 10.58119/ulg/uowrsl/loyst5
title: gFr-mp-570008-valence.dat

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DOI: 10.58119/ulg/uowrsl/p5qak7
title: mp-5860-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/uond6t
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DOI: 10.58119/ulg/uowrsl/catgq8
title: mp-998198-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/baxrab
title: gFr-mp-989638-valence.dat

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DOI: 10.58119/ulg/uowrsl/s1ndg2
title: gFr-mp-549589-valence.dat

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DOI: 10.58119/ulg/uowrsl/129wjk
title: mp-5175-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/w1ak3c
title: mp-8930-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/h5j2ar
title: gFr-mp-864954-valence.dat

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DOI: 10.58119/ulg/uowrsl/aoyv2n
title: gFr-mp-3924-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/sm0v8p
title: gFr-mp-22913-valence.dat

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DOI: 10.58119/ulg/uowrsl/hu07ds
title: mp-8452-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/w2n9qp
title: mp-736-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/saaarq
title: gFr-mp-2072-valence.dat

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DOI: 10.58119/ulg/uowrsl/21vqmw
title: gFr-mp-588-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/ed7meb
title: gFr-mp-2068-valence.dat

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DOI: 10.58119/ulg/uowrsl/t1hzjv
title: gFr-mp-7467-valence.dat

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DOI: 10.58119/ulg/uowrsl/pflzf0
title: gFr-mp-972937-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/wifdra
title: mp-553025-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/2qporz
title: mp-567373-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/nh6ccv
title: gFr-mp-27608-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/ywptmv
title: mp-15556-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/mxuid6
title: mp-9718-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/9mrv1i
title: mp-27691-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/d7whka
title: mp-10474-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/bkdfn6
title: gFr-mp-3982-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/o5fwxr
title: mp-567913-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/aqygzq
title: mp-541044-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/6xhm5k
title: gFr-mp-13992-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/vxbxsh
title: mp-6983-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/9zz8gu
title: mp-15776-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/b6k2rq
title: mp-8454-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/khqnwf
title: gFr-mp-5077-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/wyyduh
title: mp-3395-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/dutaer
title: mp-546011-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/dwkt8c
title: gFr-mp-989539-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/fmqx2x
title: mp-866291-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/16amma
title: gFr-mp-7572-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/wx7mwz
title: mp-1413-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/ehetpb
title: mp-23465-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/djbq0b
title: mp-3924-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/qom6pe
title: mp-2758-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/m8vmmy
title: gFr-mp-10760-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/bdmrhu
title: mp-23475-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/u2bn30
title: mp-2918-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/g04cop
title: mp-7575-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/grbbcv
title: gFr-mp-504838-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/fhcahm
title: gFr-mp-567636-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/vljrxq
title: gFr-mp-989522-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/oxuohd
title: gFr-mp-380-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/tl8lrt
title: gFr-mp-252-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/vv5n8w
title: gFr-mp-27839-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/0qrq7u
title: mp-989608-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/lhx2we
title: gFr-mp-7670-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/ywjias
title: gFr-mp-2695-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/jjia1n
title: mp-648-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/nhwwcz
title: mp-28994-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/9lxhov
title: gFr-mp-1008556-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/2fdyj2
title: gFr-mp-5339-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/cfxxfw
title: mp-543024-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/3nerhv
title: mp-743-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/uhqkun
title: gFr-mp-315-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/mbh9u0
title: mp-961683-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/gmz79z
title: gFr-mp-9610-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/ggokrl
title: mp-9562-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/uvznhp
title: mp-10163-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/h1yfvo
title: gFr-mp-19734-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/rfaztw
title: gFr-mp-28237-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/prw1sh
title: gFr-mp-7027-valence.dat

description: :unav
DOI: 10.23670/irj.2023.128.69.2
title: Значения расчетных параметров

description: Международный научно-исследовательский журнал, Выпуск 2 (128) 2023
DOI: 10.58119/ulg/uowrsl/7dqhxu
title: gFr-mp-10246-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/gy99mf
title: gFr-mp-976876-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/v40vh4
title: gFr-mp-223-valence.dat

description: :unav
DOI: 10.23670/irj.2023.128.69.6
title: Изменение усилий по высоте градирни

description: Международный научно-исследовательский журнал, Выпуск 2 (128) 2023
DOI: 10.58119/ulg/uowrsl/dospie
title: mp-998604-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/rgmp7k
title: gFr-mp-4081-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/rgth8a
title: gFr-mp-1784-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/b4ev8z
title: mp-553374-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/t0djvx
title: mp-1672-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/lvtstz
title: gFr-mp-6686-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/4qllac
title: gFr-mp-7251-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/2wl3dl
title: mp-8062-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/yonps2
title: gFr-mp-27421-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/4ytwwy
title: mp-2469-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/bspiyd
title: gFr-mp-10474-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/vubide
title: gFr-mp-3427-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/lo3hex
title: gFr-mp-989629-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/fyjeka
title: gFr-mp-4280-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/5dcb93
title: mp-4533-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/bmqtbw
title: gFr-mp-7188-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/1nma9h
title: gFr-mp-4609-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/gmyu42
title: mp-867203-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/wopqiq
title: mp-10418-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/pwpsr0
title: gFr-mp-24424-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/1wnq7n
title: gFr-mp-7611-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/9j3dyk
title: mp-20282-data-per-mode-valence.dat

description: :unav
DOI: 10.58119/ulg/uowrsl/wiyvus
title: gFr-mp-27456-valence.dat

description: :unav
DOI: 10.5281/zenodo.7543578
title: Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"

description: This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion" <strong>Abstract</strong> Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T&gt;C and p.His778fs), or with different types of PAs (c.-361G&gt;A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction. Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
DOI: 10.5281/zenodo.7544934
title: Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"

description: This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion" <strong>Abstract</strong> Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T&gt;C and p.His778fs), or with different types of PAs (c.-361G&gt;A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction. Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
DOI: 10.5281/zenodo.7551567
title: Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"

description: This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion" <strong>Abstract</strong> Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T&gt;C and p.His778fs), or with different types of PAs (c.-361G&gt;A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction. Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
DOI: 10.5281/zenodo.7671214
title: Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"

description: This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion" <strong>Abstract</strong> Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T&gt;C and p.His778fs), or with different types of PAs (c.-361G&gt;A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction. Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
DOI: 10.5281/zenodo.7789345
title: Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"

description: This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion" <strong>Abstract</strong> Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T&gt;C and p.His778fs), or with different types of PAs (c.-361G&gt;A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction. Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
DOI: 10.5281/zenodo.7543577
title: Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"

description: This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion" <strong>Abstract</strong> Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T&gt;C and p.His778fs), or with different types of PAs (c.-361G&gt;A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction. Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
DOI: 10.58119/ulg/uowrsl/nzrjrq
title: mp-7972-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/se2hs0
title: mp-5280-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/9ytbru
title: mp-568052-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/ic4hfx
title: mp-37091-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/dzqelx
title: mp-252-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/6jwrst
title: gFr-mp-573763-valence.dat

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DOI: 10.58119/ulg/uowrsl/kflgiu
title: mp-690785-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/f1sjua
title: mp-22901-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/taolth
title: mp-573763-data-per-mode-valence.dat

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DOI: 10.58119/ulg/uowrsl/pdi3uj
title: mp-20620-data-per-mode-valence.dat

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DOI: 10.23670/irj.2023.128.24.2
title: Определение оптимального времени термообработки шихты

description: Международный научно-исследовательский журнал, Выпуск 2 (128) 2023