cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30454576
title: Understanding the link between maternal childhood maltreatment and mother-infant bonding: postpartum depressive symptoms as a mediator

description: <b>Background:</b> Impairments in mother-infant bonding (MIB) during the postpartum period were shown to adversely affect a child’s development. Research suggests that such impairments are associated with mothers’ own childhood experiences of maltreatment. Hence, understanding factors that mediate this relationship is essential for developing targeted preventive interventions to support mothers who experienced maltreatment in their own childhood during the perinatal period. <b>Objective:</b> As postpartum depression is associated with maternal experiences of childhood maltreatment and impairments in MIB, we aimed to examine the mediating effect of postpartum depression in the relationship between maternal experiences of childhood maltreatment and impairments in MIB. <b>Methods:</b> Longitudinal data from <i>N</i> = 128 mothers in the control group of an eHealth preventive intervention (<i>I-PREGNO</i>) were analysed. Using a path model, we investigated whether the association between maternal childhood maltreatment (measured by the Childhood Trauma Screener) and MIB (measured by the Postpartum Bonding Questionnaire) was mediated by postpartum depressive symptoms (measured by the Edinburgh Postnatal Depression Scale). <b>Results:</b> Postpartum depressive symptoms fully mediated the relationship between maternal experiences of childhood maltreatment and impairments in MIB (indirect effect [<i>ab</i>]: <i>b</i> = .44, <i>p</i> = .001, 95% <i>CI</i> [.18, .70]; direct effect [<i>c’</i>]: <i>b</i> = .01, <i>p</i> = .953, 95% <i>CI</i> [−.38, .41]; total effect [<i>c</i>]: <i>b</i> = .45, <i>p</i> = .041, 95% <i>CI</i> [.02, .89]). <b>Conclusion:</b> Our results highlight the importance of addressing postpartum depression in mothers with childhood maltreatment experiences to promote MIB and to support a healthy start for the child. <b>Trial registration:</b>German Clinical Trials Register identifier: DRKS00031067. The current article examines the mediating effect of postpartum depression in the relationship between maternal experiences of childhood maltreatment and impairments in MIB during the postpartum period.Postpartum depressive symptoms fully mediated the relationship between childhood maltreatment and impairments in MIB.The results of the current article highlight the importance of addressing postpartum depression in mothers with childhood maltreatment experiences to promote MIB and to support a healthy start for the child. The current article examines the mediating effect of postpartum depression in the relationship between maternal experiences of childhood maltreatment and impairments in MIB during the postpartum period. Postpartum depressive symptoms fully mediated the relationship between childhood maltreatment and impairments in MIB. The results of the current article highlight the importance of addressing postpartum depression in mothers with childhood maltreatment experiences to promote MIB and to support a healthy start for the child.
DOI: 10.6084/m9.figshare.30454576.v1
title: Understanding the link between maternal childhood maltreatment and mother-infant bonding: postpartum depressive symptoms as a mediator

description: <b>Background:</b> Impairments in mother-infant bonding (MIB) during the postpartum period were shown to adversely affect a child’s development. Research suggests that such impairments are associated with mothers’ own childhood experiences of maltreatment. Hence, understanding factors that mediate this relationship is essential for developing targeted preventive interventions to support mothers who experienced maltreatment in their own childhood during the perinatal period. <b>Objective:</b> As postpartum depression is associated with maternal experiences of childhood maltreatment and impairments in MIB, we aimed to examine the mediating effect of postpartum depression in the relationship between maternal experiences of childhood maltreatment and impairments in MIB. <b>Methods:</b> Longitudinal data from <i>N</i> = 128 mothers in the control group of an eHealth preventive intervention (<i>I-PREGNO</i>) were analysed. Using a path model, we investigated whether the association between maternal childhood maltreatment (measured by the Childhood Trauma Screener) and MIB (measured by the Postpartum Bonding Questionnaire) was mediated by postpartum depressive symptoms (measured by the Edinburgh Postnatal Depression Scale). <b>Results:</b> Postpartum depressive symptoms fully mediated the relationship between maternal experiences of childhood maltreatment and impairments in MIB (indirect effect [<i>ab</i>]: <i>b</i> = .44, <i>p</i> = .001, 95% <i>CI</i> [.18, .70]; direct effect [<i>c’</i>]: <i>b</i> = .01, <i>p</i> = .953, 95% <i>CI</i> [−.38, .41]; total effect [<i>c</i>]: <i>b</i> = .45, <i>p</i> = .041, 95% <i>CI</i> [.02, .89]). <b>Conclusion:</b> Our results highlight the importance of addressing postpartum depression in mothers with childhood maltreatment experiences to promote MIB and to support a healthy start for the child. <b>Trial registration:</b>German Clinical Trials Register identifier: DRKS00031067. The current article examines the mediating effect of postpartum depression in the relationship between maternal experiences of childhood maltreatment and impairments in MIB during the postpartum period.Postpartum depressive symptoms fully mediated the relationship between childhood maltreatment and impairments in MIB.The results of the current article highlight the importance of addressing postpartum depression in mothers with childhood maltreatment experiences to promote MIB and to support a healthy start for the child. The current article examines the mediating effect of postpartum depression in the relationship between maternal experiences of childhood maltreatment and impairments in MIB during the postpartum period. Postpartum depressive symptoms fully mediated the relationship between childhood maltreatment and impairments in MIB. The results of the current article highlight the importance of addressing postpartum depression in mothers with childhood maltreatment experiences to promote MIB and to support a healthy start for the child.
DOI: 10.6084/m9.figshare.28920319
title: Causal relationship between inflammatory cytokines and posttraumatic stress disorder: a Mendelian randomization study and potential mechanism analysis

description: <b>Background:</b> Post-traumatic stress disorder (PTSD) is a complex condition linked to inflammation. The causality between inflammatory cytokines and PTSD risk remains unclear. <b>Methods:</b> We conducted a bidirectional two-sample Mendelian randomization (MR) study using genome-wide association study (GWAS) data from 41 inflammatory cytokines and PTSD. Additional analyses included differential gene expression, protein–protein interaction, and functional enrichment to explore underlying mechanisms. <b>Results:</b> MR analysis indicated that higher levels of stem cell factor (SCF) and interleukin-4 (IL-4) are associated with a reduced risk of PTSD. Genes POGZ and LRIG2 were identified as mediators, implicated in the TGF-beta signalling pathway. <b>Conclusion:</b> Our findings suggest a protective role of certain cytokines against PTSD and highlight potential molecular mediators. This knowledge could inform future therapeutic strategies for PTSD. This study identifies a protective link between specific inflammatory cytokines, namely stem cell factor (SCF) and interleukin-4 (IL-4), and reduced risk of posttraumatic stress disorder (PTSD), highlighting new avenues for PTSD prevention.Through detailed gene analysis, POGZ and LRIG2 genes are shown to be key mediators in the interaction between cytokines and PTSD risk, offering potential therapeutic targets.Findings emphasize the role of TGF-beta signalling in PTSD, with implications for developing targeted treatments addressing both inflammation and neuroprotective pathways. This study identifies a protective link between specific inflammatory cytokines, namely stem cell factor (SCF) and interleukin-4 (IL-4), and reduced risk of posttraumatic stress disorder (PTSD), highlighting new avenues for PTSD prevention. Through detailed gene analysis, POGZ and LRIG2 genes are shown to be key mediators in the interaction between cytokines and PTSD risk, offering potential therapeutic targets. Findings emphasize the role of TGF-beta signalling in PTSD, with implications for developing targeted treatments addressing both inflammation and neuroprotective pathways.
DOI: 10.6084/m9.figshare.28920319.v1
title: Causal relationship between inflammatory cytokines and posttraumatic stress disorder: a Mendelian randomization study and potential mechanism analysis

description: <b>Background:</b> Post-traumatic stress disorder (PTSD) is a complex condition linked to inflammation. The causality between inflammatory cytokines and PTSD risk remains unclear. <b>Methods:</b> We conducted a bidirectional two-sample Mendelian randomization (MR) study using genome-wide association study (GWAS) data from 41 inflammatory cytokines and PTSD. Additional analyses included differential gene expression, protein–protein interaction, and functional enrichment to explore underlying mechanisms. <b>Results:</b> MR analysis indicated that higher levels of stem cell factor (SCF) and interleukin-4 (IL-4) are associated with a reduced risk of PTSD. Genes POGZ and LRIG2 were identified as mediators, implicated in the TGF-beta signalling pathway. <b>Conclusion:</b> Our findings suggest a protective role of certain cytokines against PTSD and highlight potential molecular mediators. This knowledge could inform future therapeutic strategies for PTSD. This study identifies a protective link between specific inflammatory cytokines, namely stem cell factor (SCF) and interleukin-4 (IL-4), and reduced risk of posttraumatic stress disorder (PTSD), highlighting new avenues for PTSD prevention.Through detailed gene analysis, POGZ and LRIG2 genes are shown to be key mediators in the interaction between cytokines and PTSD risk, offering potential therapeutic targets.Findings emphasize the role of TGF-beta signalling in PTSD, with implications for developing targeted treatments addressing both inflammation and neuroprotective pathways. This study identifies a protective link between specific inflammatory cytokines, namely stem cell factor (SCF) and interleukin-4 (IL-4), and reduced risk of posttraumatic stress disorder (PTSD), highlighting new avenues for PTSD prevention. Through detailed gene analysis, POGZ and LRIG2 genes are shown to be key mediators in the interaction between cytokines and PTSD risk, offering potential therapeutic targets. Findings emphasize the role of TGF-beta signalling in PTSD, with implications for developing targeted treatments addressing both inflammation and neuroprotective pathways.
DOI: 10.6084/m9.figshare.28152022
title: Dream Enactment Behaviour in Post-Traumatic Stress Disorder

description: <b>Background:</b> Sleep disturbances are widely reported in Post-Traumatic Stress Disorder (PTSD). Although Dream Enactment Behaviour (DEB) has long been associated with PTSD, its high prevalence has only recently been recognized, sparking discussions about the classification of trauma-related sleep disorders. The impact of DEB on treatment outcomes in PTSD remains unexplored. <b>Objective:</b> To investigate the role of DEB in functional impairment, symptom severity, subjective sleep disturbances, and treatment response in patients with PTSD, and how it relates to Trauma-Associated Sleep Disorder (TASD). <b>Methods:</b> We analyzed data from a randomized controlled trial carried out in a specialized mental health clinic in Denmark. The trial investigated refugees with PTSD allocated to four groups receiving different combinations of PTSD therapy. Participants completed self-report questionnaires assessing functional impairment, symptom severity, and subjective sleep disturbances, including the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ), the Pittsburgh Sleep Quality Index (PSQI), and the Typical Dream Questionnaire (TDQ), at baseline and follow-up. The sample was split into two groups based on the presence of self-reported DEB, and compared at baseline and follow-up. Statistical analyses included chi-square test, Mann–Whitney U test, and regression. <b>Results:</b> A sample of 176 RBDSQ respondents was studied, of which 71% met the criteria for DEB (<i>N</i> = 125). DEB was significantly associated with a poorer treatment response on sleep quality as assessed by the PSQI (<i>N</i> = 122, <i>p</i> = .035), irrespective of treatment group. No differences were observed in functional impairment or symptom severity. Of the 67 TDQ respondents with DEB, 60% did not have trauma-related nightmares (<i>N</i> = 40). <b>Conclusions:</b> DEB is a significant feature of sleep in PTSD and seems to limit the efficacy of treatment interventions. TASD does not encompass all cases of DEB in PTSD and the concept needs further development to be clinically useful. <b>Trail Registration:</b> ClinicalTrials.gov identifier: NCT02761161; clinicaltrials.gov/study/NCT02761161. Dream Enactment Behaviour is highly prevalent in patients with Post-Traumatic Stress Disorder.The nightmares of patients with Post-Traumatic Stress Disorder and Dream Enactment Behaviour do not always involve the replay of traumatic experiences.Dream Enactment Behaviour is associated with poorer treatment outcomes on sleep quality across widely used PTSD treatment strategies. Dream Enactment Behaviour is highly prevalent in patients with Post-Traumatic Stress Disorder. The nightmares of patients with Post-Traumatic Stress Disorder and Dream Enactment Behaviour do not always involve the replay of traumatic experiences. Dream Enactment Behaviour is associated with poorer treatment outcomes on sleep quality across widely used PTSD treatment strategies.
DOI: 10.6084/m9.figshare.28152022.v1
title: Dream Enactment Behaviour in Post-Traumatic Stress Disorder

description: <b>Background:</b> Sleep disturbances are widely reported in Post-Traumatic Stress Disorder (PTSD). Although Dream Enactment Behaviour (DEB) has long been associated with PTSD, its high prevalence has only recently been recognized, sparking discussions about the classification of trauma-related sleep disorders. The impact of DEB on treatment outcomes in PTSD remains unexplored. <b>Objective:</b> To investigate the role of DEB in functional impairment, symptom severity, subjective sleep disturbances, and treatment response in patients with PTSD, and how it relates to Trauma-Associated Sleep Disorder (TASD). <b>Methods:</b> We analyzed data from a randomized controlled trial carried out in a specialized mental health clinic in Denmark. The trial investigated refugees with PTSD allocated to four groups receiving different combinations of PTSD therapy. Participants completed self-report questionnaires assessing functional impairment, symptom severity, and subjective sleep disturbances, including the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ), the Pittsburgh Sleep Quality Index (PSQI), and the Typical Dream Questionnaire (TDQ), at baseline and follow-up. The sample was split into two groups based on the presence of self-reported DEB, and compared at baseline and follow-up. Statistical analyses included chi-square test, Mann–Whitney U test, and regression. <b>Results:</b> A sample of 176 RBDSQ respondents was studied, of which 71% met the criteria for DEB (<i>N</i> = 125). DEB was significantly associated with a poorer treatment response on sleep quality as assessed by the PSQI (<i>N</i> = 122, <i>p</i> = .035), irrespective of treatment group. No differences were observed in functional impairment or symptom severity. Of the 67 TDQ respondents with DEB, 60% did not have trauma-related nightmares (<i>N</i> = 40). <b>Conclusions:</b> DEB is a significant feature of sleep in PTSD and seems to limit the efficacy of treatment interventions. TASD does not encompass all cases of DEB in PTSD and the concept needs further development to be clinically useful. <b>Trail Registration:</b> ClinicalTrials.gov identifier: NCT02761161; clinicaltrials.gov/study/NCT02761161. Dream Enactment Behaviour is highly prevalent in patients with Post-Traumatic Stress Disorder.The nightmares of patients with Post-Traumatic Stress Disorder and Dream Enactment Behaviour do not always involve the replay of traumatic experiences.Dream Enactment Behaviour is associated with poorer treatment outcomes on sleep quality across widely used PTSD treatment strategies. Dream Enactment Behaviour is highly prevalent in patients with Post-Traumatic Stress Disorder. The nightmares of patients with Post-Traumatic Stress Disorder and Dream Enactment Behaviour do not always involve the replay of traumatic experiences. Dream Enactment Behaviour is associated with poorer treatment outcomes on sleep quality across widely used PTSD treatment strategies.
DOI: 10.6084/m9.figshare.29950151
title: Yoga as a pre-treatment of EMDR to treat childhood abuse-related PTSD: feasibility and pilot study

description: <b>Background:</b> Yoga, a mind-body practice that enhances emotional regulation and self-awareness, may be an effective stabilisation tool for trauma-focused therapy, particularly for patients with childhood abuse-related posttraumatic stress disorder (CA-PTSD), who exhibit strong avoidance strategies. <b>Objective:</b> This study aimed to test the efficacy of group yoga sessions followed by individual EMDR sessions on PTSD symptoms. Secondary objectives included evaluating the efficacy of this combined treatment on the most common associated comorbidities, and measuring the adherence and effectiveness of EMDR sessions. <b>Methods:</b> 32 adult women with CA-PTSD were randomly assigned to either a Yoga + EMDR group (10 weekly yoga sessions followed by 10 weekly EMDR sessions) or a Wait + EMDR group (12 weeks of waiting followed by 10 weekly EMDR sessions). Assessments were conducted at baseline, week 12, and week 24, primarily using validated self-report questionnaires. <b>Results:</b> While PTSD symptoms and most comorbidities showed no significant group differences, the Yoga + EMDR group exhibited significant improvements in anxiety and emotional dysregulation, fewer dropouts, and more effective EMDR sessions compared to the Wait + EMDR group. The study faced a limitation as the overall therapy duration extended beyond the protocol, rapidly preventing new recruitments. <b>Conclusions:</b> Yoga preceding EMDR shows promise in enhancing emotion regulation and EMDR effectiveness for CA-PTSD patients. Prior group yoga sessions enhanced the adherence and efficacy of individual EMDR sessions.Participants who received yoga sessions demonstrated significant improvements in emotional regulation and reduced anxiety compared to participants who did not.The prolonged nature of EMDR therapy for CA-PTSD can strain the resources of medical centres.Integrating yoga as both a pre- and co-treatment may sustainably improve EMDR efficacy and ultimately shorten therapy duration. Prior group yoga sessions enhanced the adherence and efficacy of individual EMDR sessions. Participants who received yoga sessions demonstrated significant improvements in emotional regulation and reduced anxiety compared to participants who did not. The prolonged nature of EMDR therapy for CA-PTSD can strain the resources of medical centres. Integrating yoga as both a pre- and co-treatment may sustainably improve EMDR efficacy and ultimately shorten therapy duration.
DOI: 10.6084/m9.figshare.29950151.v1
title: Yoga as a pre-treatment of EMDR to treat childhood abuse-related PTSD: feasibility and pilot study

description: <b>Background:</b> Yoga, a mind-body practice that enhances emotional regulation and self-awareness, may be an effective stabilisation tool for trauma-focused therapy, particularly for patients with childhood abuse-related posttraumatic stress disorder (CA-PTSD), who exhibit strong avoidance strategies. <b>Objective:</b> This study aimed to test the efficacy of group yoga sessions followed by individual EMDR sessions on PTSD symptoms. Secondary objectives included evaluating the efficacy of this combined treatment on the most common associated comorbidities, and measuring the adherence and effectiveness of EMDR sessions. <b>Methods:</b> 32 adult women with CA-PTSD were randomly assigned to either a Yoga + EMDR group (10 weekly yoga sessions followed by 10 weekly EMDR sessions) or a Wait + EMDR group (12 weeks of waiting followed by 10 weekly EMDR sessions). Assessments were conducted at baseline, week 12, and week 24, primarily using validated self-report questionnaires. <b>Results:</b> While PTSD symptoms and most comorbidities showed no significant group differences, the Yoga + EMDR group exhibited significant improvements in anxiety and emotional dysregulation, fewer dropouts, and more effective EMDR sessions compared to the Wait + EMDR group. The study faced a limitation as the overall therapy duration extended beyond the protocol, rapidly preventing new recruitments. <b>Conclusions:</b> Yoga preceding EMDR shows promise in enhancing emotion regulation and EMDR effectiveness for CA-PTSD patients. Prior group yoga sessions enhanced the adherence and efficacy of individual EMDR sessions.Participants who received yoga sessions demonstrated significant improvements in emotional regulation and reduced anxiety compared to participants who did not.The prolonged nature of EMDR therapy for CA-PTSD can strain the resources of medical centres.Integrating yoga as both a pre- and co-treatment may sustainably improve EMDR efficacy and ultimately shorten therapy duration. Prior group yoga sessions enhanced the adherence and efficacy of individual EMDR sessions. Participants who received yoga sessions demonstrated significant improvements in emotional regulation and reduced anxiety compared to participants who did not. The prolonged nature of EMDR therapy for CA-PTSD can strain the resources of medical centres. Integrating yoga as both a pre- and co-treatment may sustainably improve EMDR efficacy and ultimately shorten therapy duration.