cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24042828
title: Supplementary Material for: The involvement of PGRMC1 signaling in cognitive impairment induced by long-term clozapine treatment in rats

description: Introduction Progesterone receptor component 1 (PGRMC1) has been identified as a potential target in atypical antipsychotic drug-induced metabolic disturbances as well as neuroprotection in the central nervous system. In our study, we aimed to figure out the essential role of PGRMC1 signaling pathway underlying clozapine-induced cognitive impairment. Methods In male SD rats, we utilized recombinant adeno-associated viruses (AAV/BBB2.0) and the specific inhibitor of PGRMC1 (AG205) to regulate the expression of PGRMC1 in the brain, with a special focus on the hippocampus. Treatments of clozapine and AG205 were conducted for 28 days and subsequent behavioral tests including modified Elevated Plus Maze (mEPM) and Morris Water Maze (MWM) were conducted to evaluate the cognitive performance. Hippocampal protein expressions were measured by western blotting. Results Our study showed that long-term clozapine administration led to cognitive impairment as confirmed by behavioral tests as well as histopathological examination in the hippocampus. Clozapine inhibited neural survival through the PGRMC1/EGFR/GLP1R-PI3K-Akt signaling pathway, leading to a decrease in the downstream survival factor brain-derived neurotrophic factor (BDNF), and simultaneously promoted neural apoptosis in the rat hippocampus. Intriguingly, by targeting at the hippocampal PGRMC1, we found that inhibiting PGRMC1 mimics, while its upregulation notably mitigates clozapine-induced cognitive impairment through PGRMC1 and its downstream signaling pathways. Conclusion PGRMC1 overexpression could protect hippocampus-dependent cognitive impairment induced by clozapine. This effect appears to arise, in part, from the upregulated expression of PGRMC1/EGFR/GLP1R and the activation of downstream PI3K-Akt-BDNF and caspase-3 signaling pathways.
DOI: 10.6084/m9.figshare.24083769
title: Supplementary Material for: IS THERE ANY RISK FOR METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH PSYCHIATRIC DISORDERS?

description: Objective: We aimed to investigate the risk of antipsychotic drug treatment in the development of metabolic syndrome (MetS) in children and adolescents and to determine which psychiatric disorder is more associated with MetS in the pediatric population. Methods: The sample consisted of 118 children and adolescents (88 used psychotropic medication). The hemogram, fasting blood glucose, lipid profile, weight, and blood pressure levels from all the participants and information regarding medication doses of the patient group at the sixth month of the treatment process were obtained. Results: Bipolar Disorder (BPD) was the only psychiatric disorder associated with MetS. Quetiapine and Valproic acid were found to have increasing effects on MetS. Weight gain and the increase in systolic and diastolic blood pressure significantly increased the likelihood of MetS. Hierarchical logistic regression analyses revealed that quetiapine increased the risk of metabolic syndrome through weight gain, and valproic acid increased metabolic syndrome risk through systolic blood pressure. Conclusion: Especially BPD and psychotropic use in children and adolescents disrupt metabolic regulation and pose a risk for MetS. Determining the risk factors causing MetS, especially in children and adolescents, plays a significant role in preventing mortality and morbidity at advanced ages.
DOI: 10.6084/m9.figshare.24105501
title: Supplementary Material for: A case of oropharyngeal carcinoma with an oblique neck that benefited from transoral robotic surgery

description: Transoral robotic surgery (TORS) and transoral videolaryngoscopic surgery (TOVS) are minimally invasive procedures for early-stage head and neck cancers. However, due to its unique nature, transoral resection often leads to skeletal and anatomical disorders. We describe a case in which TORS was used in a 71-year-old man with a skeletal disorder, spastic stridor, and a T2N1M0 stage I p16-positive oropharyngeal carcinoma. Prior to the procedure, he underwent right cervical dissection (levels II-IV). Although he had an oblique neck, the right side of his neck was naturally hyperextended because the dissection was performed on the right side. The right facial, lingual, and external carotid arteries were ligated in preparation for TORS. Postoperative pathological examination revealed no extranodal involvement of the metastatic lymph nodes. A two-stage TOVS procedure was performed for the oropharyngeal tumor, in which the surgeon was required to be positioned at the patient's head to allow direct manipulation. This makes the neck and oral cavity more susceptible to the skeletal effects. In contrast, in TORS, the da Vinci insertion angle can be set to match the angle of the neck, allowing surgeons to operate with less skeletal influence. TORS is more useful in this setting.
DOI: 10.6084/m9.figshare.24173844
title: Supplementary Material for: Different Roles of Functional and Structural Renal Markers Measured at Discontinuation of Renal Replacement Therapy for Acute Kidney Injury

description: Introduction: Severe acute kidney injury (AKI) requiring renal replacement therapy (RRT) has been associated with an unacceptably high mortality of 50% or more. Successful discontinuation of RRT is thought to be linked to better outcomes. Although functional and structural renal markers have been evaluated in AKI, little is known about their roles in predicting outcomes at the time of RRT discontinuation. Methods: In this prospective single-center cohort study, we analyzed patients who received continuous RRT (CRRT) for AKI between August 2016 and March 2018 in the intensive care unit of The University of Tokyo Hospital (Tokyo, Japan). Clinical parameters and urine samples were obtained at CRRT discontinuation. Successful CRRT discontinuation was defined as neither resuming CRRT for 48 hours nor receiving intermittent hemodialysis for 7 days from the CRRT termination. Major adverse kidney events (MAKEs) were defined as death, requirement for dialysis, or a decrease in the estimated glomerular filtration rate (eGFR) of more than 25% from the baseline at day 90. Results: Of 73 patients who received CRRT for AKI, 59 successfully discontinued CRRT and 14 could not. Kinetic eGFR, urine volume, urinary neutrophil gelatinase-associated lipocalin (NGAL), and urinary L-type fatty acid binding protein (L-FABP) were predictive for CRRT discontinuation. Of these factors, urine volume had the highest area under the curve (AUC) 0.91 with 95% confidence interval [0.80–0.96] for successful CRRT discontinuation. For predicting MAKEs at day 90, the urinary NGAL showed the highest AUC 0.76 [0.62–0.86], whereas kinetic eGFR and urine volume failed to show statistical significance (AUC 0.49 [0.35–0.63] and AUC 0.59 [0.44–0.73], respectively). Conclusions: Our prospective study confirmed that urine volume, a functional renal marker, predicted successful discontinuation of RRT and that urinary NGAL, a structural renal marker, predicted long-term renal outcomes. These observations suggest that the functional and structural renal makers play different roles in predicting the outcomes of severe AKI requiring RRT.
DOI: 10.6084/m9.figshare.24203811
title: Supplementary Material for: A case of tumor lysis syndrome during palliative radiotherapy for breast cancer metastases

description: Tumor lysis syndrome (TLS) is the rapid disintegration of a malignant tumor treated with anticancer drugs or radiation, causing electrolyte abnormalities such as elevated uric acid levels, elevated potassium and phosphorus levels, and decreased calcium levels. These abnormalities can lead to hypotension, renal dysfunction, consciousness disorders, and even death in some cases. The current patient was a 65-year-old woman who had breast cancer with local invasion, lung metastasis, and bone metastasis from the time of the initial disease onset. Despite the administration of various chemotherapy and hormone therapy regimens, the tumor increased gradually, and at 2 years and 5 months after the initial onset, pain and bleeding from metastatic infiltration of the cervical lymph nodes were noted. Therefore, radiotherapy was indicated for palliation of pain and bleeding caused by metastatic invasion of the cervical lymph nodes. Irradiation (30 Gy/10 fr) was performed with a 3-field technique using 4MVX and 10MVX. Approximately 11 h after the initial irradiation, symptoms such as respiratory distress, tachycardia, and hypotension were observed. Blood tests revealed hyperuricemia and hyperkalemia, leading to a diagnosis of TLS. Dialysis and electrolyte correction were immediately initiated resulting in normalization of electrolytes and stabilization of the blood pressure. It is crucial to understand that TLS is relatively rare but can occur after radiation therapy or in solid tumors, and warrants a prompt response if suspected based on symptoms or blood findings.
DOI: 10.5281/zenodo.8070964
title: Printed Dual-Frequency Directional Antenna Loaded with Dual-Parasitic Strip

description: Dataset 1-23 are the raw data from CST studio suite analysis software (CST). A series of simulations are performed on the MS-to-CPS transition, the dual dipole element, the reflectors, and the parasitic strip to determine the optimal antenna design. Dataset 24-28 are the raw data from the measured results whose are compared with the simulated results of the optimal antenna design. <strong>Additional Supporting Information</strong> Dataset 1 and 2 are the raw data of Figure 2. Dataset 3 is the raw data of Figure 3. Dataset 4, 5, and 6 are the raw data of Figure 5. Dataset 7 is the raw data of Figure 6. Dataset 8 is the raw data of Figure 9. Dataset 9 is the raw data of Figure 10. Dataset 10 is the raw data of Figure 11. Dataset 11 and 12 are the raw data of Figure 12. Dataset 13 and 14 are the raw data of Figure 13. Dataset 15 and 16 are the raw data of Figure 14. Dataset 17 and 18 are the raw data of Figure 15. Dataset 19 and 20 are the raw data of Figure 16. Dataset 21 is the raw data of Figure 17. Dataset 22 is the raw data of Figure 18. Dataset 23 is the raw data of Figure 19. Dataset 24 is the raw data of Figure 21. Dataset 25, 26, 27, and 28 are the raw data of Figure 22.
DOI: 10.6084/m9.figshare.24155967
title: Supplementary Material for: Large retroperitoneal teratoma presenting with unilateral hydronephrosis in an infant: a case report and review of the literature

description: Teratoma is a type of germ cell tumor layer that appears in the gonadal, sacrococcygeal, mediastinal, and retroperitoneal regions. Primary retroperitoneal teratoma is rare and asymptomatic but can present with symptoms due to a mass effect on neighboring organs. These tumors have to be considered in the differential diagnosis of a mass in the abdominal cavity of children to distinguish between Wilms’ tumor, neuroblastoma, and other intraabdominal lesions. We presented an infant boy with protrusion of the left upper quadrant of the abdomen and a palpable abdominal mass that had progressively enlarged. An abdominal computed tomography (CT) scan revealed a large retroperitoneal cystic, solid mass on the left side of the abdominal cavity, causing pressure on the left ureter. Also, hydronephrosis of the left kidney was seen with a decreased enhancement of the left kidney due to obstruction uropathy. The mass was suspicious on imaging for a retroperitoneal teratoma. The patient underwent laparotomy, and excision of the huge retroperitoneal mass was done. The final diagnosis was an immature teratoma grade 3, and the patient was discharged in good condition. Retroperitoneal teratomas are rare tumors in infants. These tumors would be an incident diagnosis or diagnosed by the mass effect of giant tumors on other organs. They must be considered in the differential diagnosis of intraabdominal tumors in children. Hydronephrosis and obstructive uropathy can be rare consequences of the mass effects of these tumors.
DOI: 10.6084/m9.figshare.24241252
title: Supplementary Material for: Venous Excess Doppler Ultrasound (VExUS): a Visual Guide to Decongestion in Cardiorenal syndrome

description: Promptly recognizing congestion, both clinical and hemodynamic is paramount in the management of patients with heart failure. The pathophysiology of congestion involves a complex interplay of absolute fluid gain, volume redistribution from venous capacitance beds to the central venous circulation, inadequate excretion due to renal dysfunction, salt and water retention, and endothelial dysfunction. While congestive nephropathy is gaining wider recognition as a distinct variant of hemodynamic acute kidney injury (AKI), there are limited bedside diagnostic tools for proper evaluation of these patients. In this manuscript, we describe a case of AKI where POCUS helped us diagnose clinically silent congestion as well as monitor the response to therapy. A patient with heart failure with mildly reduced ejection fraction was initially administered intravenous fluids for rise in serum creatinine attributed to volume depletion. However, POCUS demonstrated a completely different scenario with severe venous congestion. Both sonographic stigmata of congestion and serum creatinine improved with diuretic therapy. Furthermore, serial VExUS (Venous Excess Doppler Ultrasound) scans facilitated the visualization of decongestion in real time.
DOI: 10.6084/m9.figshare.23964966
title: Supplementary Material for: Isolation and Cultivation of Vascular Smooth Muscle Cells from the Mouse Circle of Willis

description: Introduction: Culturing cerebrovascular smooth muscle cells (CVSMCs) in vitro can provide a model for studying many cerebrovascular diseases. This study describes a convenient and efficient method to obtain mouse CVSMCs by enzyme digestion. Methods: Mouse circle of Willis was isolated, disgested, and cultured with platelet-derived growth factor-BB (PDGF-BB) to promote CVSMC growth, and CVSMCs were identified by morphology, immunofluorescence analysis, and flow cytometry. The effect of PDGF-BB on vascular smooth muscle cell (VSMC) proliferation was evaluated by cell counting kit (CCK)-8 assay, morphological observations, western blotting, and flow cytometry. Results: CVSMCs cultured in a PDGF-BB-free culture medium had a typical peak-to-valley growth pattern after approximately 14 days. Immunofluorescence staining and flow cytometry detected strong positive expression of the cell type-specific markers alpha-smooth muscle actin (α-SMA),mooth muscle myosin heavy chain 11(SMMHC), smooth muscle protein 22 (SM22), calponin, and desmin. In the CCK-8 assay and western blotting, cells incubated with PDGF-BB had significantly enhanced proliferation compared to those without PDGF-BB. Conclusion: We obtained highly purified VSMCs from the mouse circle of Willis using simple methods, providing experimental materials for studying the pathogenesis and treatment of neurovascular diseases in vitro. Moreover, the experimental efficiency improved with PDGF-BB, shortening the cell cultivation period.
DOI: 10.5281/zenodo.7646796
title: Data used in the paper titled 'Reconstructing and Nowcasting the Rainfall Field by a CML Network'

description: The dataset contains the CML, OTT disdrometer, rain gauge and radar data as well as some of the scripts used in the paper titled 'Reconstructing and Nowcasting the Rainfall Field by a CML Network'
DOI: 10.5281/zenodo.7798697
title: PASS molecular dataset

description: A dataset containing 475K PASs molecules
DOI: 10.5281/zenodo.8151782
title: Observed Rainfall And CMIP6 Data

description: The gridded rainfall datasets used in this analysis were sourced from the Indian Meteorological Department (IMD). These datasets were collected on a daily basis from 1951 to 2021 and were obtained from the National Climate Centre (NCC) of IMD from the following URL: https://www.imdpune.gov.in/lrfindex.php. The dataset covers the Indian River Basins (IRBs) and has been generated at high resolution by assimilating data from 6955 rain gauge stations spread across the IRBs. For the simulated daily precipitation spanning the years 2021 to 2100, four different Shared Socioeconomic Pathways (SSPs) were considered: SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5. The simulated precipitation outputs were derived from the Coupled Model Intercomparison Project-6 (CMIP6) and were obtained from the following URL: https://esgf-node.llnl.gov/search/cmip6/. All 12 models of CMIP6 were downloaded, specifically using the variant label r1i1p1f1 as an initial condition.
DOI: 10.5281/zenodo.8319741
title: Space weather disrupts nocturnal bird migration

description: Our paper tests for the effects of space weather-induced geomagnetic disturbances on radar-detected nocturnal bird migration. We find evidence for a ~10% decrease of migration intensity after controlling for weather variables and spatiotemporal autocorrelation, and also for a decrease in the effort birds spent flying against the wind in the fall, especially under overcast conditions. This repository provides the data and the code used to arrive at these conclusions and plot the main results. Weather radar data was processed from the NOAA NEXRAD network, weather data was accessed from the North American Regional Reanalysis, and magnetometer data was accessed from the SuperMAG inventory.
DOI: 10.6084/m9.figshare.23302427
title: Aromatic pentaamide macrocycles bind anions with high-affinity for transport across biomembranes

description: 1) Matlab code for fitting in Figure 4 (anion_sele_fianl.m, ion_cl_final.m, v_corrx2021.m). 2) Source data for Figure S5, S6, S10-S14. 3) Analysis code and resulting data spreadsheets for ASL experiment. (height_analysis.fig, height_analysis.m, Raw ASL Data.xlsx)
DOI: 10.6084/m9.figshare.23598774
title: Supplementary Material for: Pro-inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis

description: PR domain containing 1 with zinc finger domain (PRDM1) has been reported as a promoter of inflammation, which is a critical process involved in the pathogenesis of acute gouty arthritis. Herein, we sought to ascertain the function of PRDM1 in the development of acute gouty arthritis and related mechanisms. At first, peripheral blood-derived monocytes from patients with acute gouty arthritis and healthy individuals were collected as experimental samples. Then, macrophages were induced from monocytes using phorbol myristate acetate (PMA). The expression patterns of PRDM1, sirtuin 2 (SIRT2), and NLR family, pyrin domain-containing 3 (NLRP3) were characterized by RT-qPCR and Western blot assay. PMA-induced macrophages were stimulated by monosodium urate (MSU) for in vitro experimentation. Meanwhile, a murine model of MSU-induced acute gouty arthritis was established for in vivo validation. PRDM1 was highly expressed while SIRT2 poorly expressed in patients with acute gouty arthritis. Loss of PRDM1 could reduced NLRP3 inflammasome and mature IL-1β levels and down-regulate inflammatory cytokines in macrophages, which contributed to protection against acute gouty arthritis. Furthermore, results showed that PRDM1 could inhibit SIRT2 expression via binding to the deacetylase SIRT2 promoter. Finally, the in vivo experiments demonstrated that PRDM1 increased NLRP3 inflammasome and mature IL-1β through transcriptional inhibition of SIRT2, whereby aggravating MSU-induced acute gouty arthritis. To sum up, PRDM1 increased NLRP3 inflammasome through inhibiting SIRT2, consequently aggravating MSU-induced acute gouty arthritis.
DOI: 10.6084/m9.figshare.23626644
title: Supplementary Material for: Dilemmas in the management of an infant with neuroblastoma metastasized to the muscles

description: The risk stratification of infants with metastatic neuroblastoma (NB) has evolved over time from stage 4/M or IVs/4S/MS/Ms according to various staging systems. Despite these developments for some genetic aberrations the prognostic value and the impact of soft tissue metastases in infants are not fully understood, nor well described in the different classification systems, hampering the definitions to uniformly treat patients and prediction of prognosis. A literature review on staging of infants with M/MS disease was performed at the occasion of the diagnosis of NB in an 8-month-old boy who presented with atypical metastatic sites in soft tissue and aberrant tumor biology. The definitions of stage 4/4S/4s/M/MS/Ms were evaluated and compared to enable tumor risk stratification and inform management. International NB groups use different criteria for defining stage of infants with metastasized NB, resulting in differences in management. Limited literature is available on soft tissue metastases, especially muscular metastases, and are poorly incorporated into management guidelines mainly due to the lack of data. The uncertain prognosis of rare genetic aberrancies may add to the difficulties in treatment decisions. In some rare cases of NB in infants the international treatment classification is not sufficient for staging and treatment decisions. Based on tumor progression, biology of unknown significance and a lack of evidence to classify a child under 12 months with NB and multiple muscular metastases, the patient was treated as stage 4/M and intermediate risk protocols with a favorable outcome.
DOI: 10.6084/m9.figshare.23741925
title: Supplementary Material for: Balancing efficacy and tolerability of first-line systemic therapies for advanced hepatocellular carcinoma: a network metanalysis

description: Background: Atezolizumab+Bevacizumab represents the current standard of care for first-line treatment of advanced HCC. However, direct comparison with other combination treatments including immune-checkpoint inhibitors(ICI)+tyrosine-kinase inhibitors(TKIs) are lacking. Objectives: This network meta-analysis(NMA) aims to indirectly compare the efficacy and the safety of first-line systemic therapies for unresectable-advanced HCC. Method:A literature search of MEDLINE, EMBASE and SCOPUS databases was conducted up to 31st October, 2022. Phase III randomized controlled trials(RCTs) testing TKIs, including Sorafenib and Lenvatinib, or ICIs reporting overall survival(OS) and progression-free survival(PFS) were included. Individual survival data were extracted from OS and PFS curves to calculate restricted mean survival time (RMST). A Bayesian NMA was performed to compare treatments in terms of efficacy(15- and 30-month OS, 6-month PFS) and safety, represented by grade≥3(severe)adverse events(SAEs). The incremental safety-effectiveness ratio(ISER) as measure of net health benefit was calculated as the difference in SAEs probability divided by survival difference between the 2 most effective treatments. Results:Nine RCTs enrolling 6600 patients were included. Atezolizumab plus bevacizumab showed the highest probability(88%)of achieving the 30-month OS landmark. Lenvatinib showed a probability of 86% of achieving best PFS outcomes. ICI monotherapies ranked as most tolerable. Atezolizumab plus Bevacizumab showed the best net health benefit for OS, compared to Durvalumab plus Tremelimumab. When evaluating the net health benefit for PFS, at a willingness-to-risk threshold of 10% of SAEs for life-month gained, Atezolizumab plus Bevacizumab was favored in 78% of cases, while at threshold of 30% of SAEs for life-month gained, Lenvatinib was favored in 76% of cases. Conclusions: Atezolizumab plus Bevacizumab is the best treatment in terms of net benefit and therefore it should be recommended as standard of care. Compared to Atezolizumab plus Bevacizumab, Lenvatinib monotherapy had the best net benefit for PFS when physicians and patients are available to accept a higher risk of toxicity.