cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19923450.v1
title: Meiotic self-pairing of the Psalidodon (Characiformes, Characidae) iso-B chromosome: A successful perpetuation mechanism

description: Abstract B chromosomes are non-essential additional genomic elements present in several animal and plant species. In fishes, species of the genus Psalidodon (Characiformes, Characidae) harbor great karyotype diversity, and multiple populations carry different types of non-essential B chromosomes. This study analyzed how the dispensable supernumerary B chromosome of Psalidodon paranae behaves during meiosis to overcome checkpoints and express its own meiosis-specific genes. We visualized the synaptonemal complexes of P. paranae individuals with zero, one, or two B chromosomes using immunodetection with anti-medaka SYCP3 antibody and fluorescence in situ hybridization with a (CA)15 microsatellite probe. Our results showed that B chromosomes self-pair in cells containing only one B chromosome. In cells with two identical B chromosomes, these elements remain as separate synaptonemal complexes or close self-paired elements in the nucleus territory. Overall, we reveal that B chromosomes can escape meiotic silencing of unsynapsed chromatin through a self-pairing process, allowing expression of their own genes to facilitate regular meiosis resulting in fertile individuals. This behavior, also seen in other congeneric species, might be related to their maintenance throughout the evolutionary history of Psalidodon.
DOI: 10.6084/m9.figshare.19923450
title: Meiotic self-pairing of the Psalidodon (Characiformes, Characidae) iso-B chromosome: A successful perpetuation mechanism

description: Abstract B chromosomes are non-essential additional genomic elements present in several animal and plant species. In fishes, species of the genus Psalidodon (Characiformes, Characidae) harbor great karyotype diversity, and multiple populations carry different types of non-essential B chromosomes. This study analyzed how the dispensable supernumerary B chromosome of Psalidodon paranae behaves during meiosis to overcome checkpoints and express its own meiosis-specific genes. We visualized the synaptonemal complexes of P. paranae individuals with zero, one, or two B chromosomes using immunodetection with anti-medaka SYCP3 antibody and fluorescence in situ hybridization with a (CA)15 microsatellite probe. Our results showed that B chromosomes self-pair in cells containing only one B chromosome. In cells with two identical B chromosomes, these elements remain as separate synaptonemal complexes or close self-paired elements in the nucleus territory. Overall, we reveal that B chromosomes can escape meiotic silencing of unsynapsed chromatin through a self-pairing process, allowing expression of their own genes to facilitate regular meiosis resulting in fertile individuals. This behavior, also seen in other congeneric species, might be related to their maintenance throughout the evolutionary history of Psalidodon.
DOI: 10.6084/m9.figshare.19923455
title: “Running things through the body is always different from putting that into words, right?”: health education, interculturality and the theater of the oppressed

description: Abstract We present the systematization of an in-service teacher training experience developed in 2018-2019, articulating Health Education and extended critical Interculturality, through the Theater of the Oppressed. Based on a real case, the participants created images with their own bodies that represented different situations of oppression, which were to be analyzed and intervened with collectively. We focus the systematization on three axes: knowledge, positions and reflections on Health and Interculturality; what happened when the body and feelings were put into play; and during the intervention of the images, which allowed for reflection on the possibilities of transforming reality. The systematization led us to recognize that the Image Theater approach implied a learning process developed in the practice itself, which caused multiple positions to be made explicit, including politically incorrect ones. We underline the richness of devices that enable the dimension of the transformation of reality in topics such as Health and Interculturality.
DOI: 10.6084/m9.figshare.19923456
title: Pulpal blood flow changes and pain scores related to using Superelastic 0.018-inch Nickel Titanium as the first orthodontic alignment archwire: a prospective clinical trial

description: Abstract Background Optimal orthodontic force results in maximum rate of tooth movement without tissue damage. Even though starting orthodontic treatment with a thicker archwire may shorten treatment duration, the evidence on the effect of using 0.018-inch NiTi as the first alignment archwire on pulpal blood flow (PBF) status is still scarce. Objectives to record PBF changes and pain scores associated with using 0.018-inch NiTi as the first alignment archwire during fixed orthodontic treatment. Methodology Patients were selected from subjects attending postgraduate orthodontic teaching clinics at Jordan University of Science and Technology. In total, forty healthy patients who exhibited mild lower arch crowding were included. A split-mouth trial design was used. Each patient received two archwire sizes at one time joined in the midline by crimpable hook and applied in the lower arch. Patients were assigned into one of two groups based on archwire sizes used. Group 1: 0.014-inch and 0.018-inch NiTi (Six males, 14 females aged 19.4±1.33 years) and Group 2: 0.016-inch and 0.018-inch NiTi (Seven males, 13 females aged 19.6±1.45 years). The archwire size group was randomly allocated with a 1:1 allocation ratio. A Laser Doppler Flowmeter was used to measure PBF at different time intervals (T0-T5). Pain scores were recorded using a visual analogue scale (VAS). A repeated measures ANOVA and a post-hoc Bonferroni comparison tests were conducted to examine differences at the different time points before and during orthodontic alignment. Results For all studied archwire sizes, PBF decreased 20 minutes after their placement. Most PBF changes occurred within 24hours and continued to decrease until 72 hours after archwire placement where the maximum reduction was reached. Eventually, normal values were reverted within 1 month. PBF changes were similar between all alignment – groups. Conclusions Initial orthodontic alignment with 0.018-inch NiTi does not cause irreversible changes to pulpal vasculature or produces higher pain scores.
DOI: 10.6084/m9.figshare.19923456.v1
title: Pulpal blood flow changes and pain scores related to using Superelastic 0.018-inch Nickel Titanium as the first orthodontic alignment archwire: a prospective clinical trial

description: Abstract Background Optimal orthodontic force results in maximum rate of tooth movement without tissue damage. Even though starting orthodontic treatment with a thicker archwire may shorten treatment duration, the evidence on the effect of using 0.018-inch NiTi as the first alignment archwire on pulpal blood flow (PBF) status is still scarce. Objectives to record PBF changes and pain scores associated with using 0.018-inch NiTi as the first alignment archwire during fixed orthodontic treatment. Methodology Patients were selected from subjects attending postgraduate orthodontic teaching clinics at Jordan University of Science and Technology. In total, forty healthy patients who exhibited mild lower arch crowding were included. A split-mouth trial design was used. Each patient received two archwire sizes at one time joined in the midline by crimpable hook and applied in the lower arch. Patients were assigned into one of two groups based on archwire sizes used. Group 1: 0.014-inch and 0.018-inch NiTi (Six males, 14 females aged 19.4±1.33 years) and Group 2: 0.016-inch and 0.018-inch NiTi (Seven males, 13 females aged 19.6±1.45 years). The archwire size group was randomly allocated with a 1:1 allocation ratio. A Laser Doppler Flowmeter was used to measure PBF at different time intervals (T0-T5). Pain scores were recorded using a visual analogue scale (VAS). A repeated measures ANOVA and a post-hoc Bonferroni comparison tests were conducted to examine differences at the different time points before and during orthodontic alignment. Results For all studied archwire sizes, PBF decreased 20 minutes after their placement. Most PBF changes occurred within 24hours and continued to decrease until 72 hours after archwire placement where the maximum reduction was reached. Eventually, normal values were reverted within 1 month. PBF changes were similar between all alignment – groups. Conclusions Initial orthodontic alignment with 0.018-inch NiTi does not cause irreversible changes to pulpal vasculature or produces higher pain scores.
DOI: 10.6084/m9.figshare.19923458
title: Effectiveness and potential drug interactions in antiviral therapy for the treatment of chronic hepatitis C: real-life data from a specialized center in southern Brazil

description: Direct-acting antivirals used in the treatment of hepatitis C have demonstrated high rates of efficacy, are well tolerated and considered safe. However, they are not free of drug interactions. To describe the effectiveness of hepatitis C treatment and the incidence and severity of potential drug interactions between drugs used during this treatment. A cross-sectional study with 148 patients who began treatment for hepatitis C between April and June 2016 in a specialized center in Brazil. Drug interactions were identified in the Truven Health Analytic/DynaMed Plus and Hep-C Interactions databases. Regarding treatment outcome, 93.9% of patients achieved SVR, 2.7% relapsed and 3.4% did not return after the end of the follow-up period. A total of 328 chronic diseases were identified (71 different diseases), and 88.5% of the patients had at least one chronic disease. The patients reported the use of 474 drugs (121 different drugs), with 3.2 drugs per patient on average. We identified 265 potential drug interactions, classified as important (6.0%), with clinical significance (20.7%) and without clinical significance or with insufficient data (69.4%). Cirrhotic patients had a higher average number of potential drug interactions than non-cirrhotic patients (2.51 x 0.79, p = 0.000). Hepatitis C treatment with direct-acting antivirals are effective and safe for most of patients.
DOI: 10.6084/m9.figshare.19923458.v1
title: Effectiveness and potential drug interactions in antiviral therapy for the treatment of chronic hepatitis C: real-life data from a specialized center in southern Brazil

description: Direct-acting antivirals used in the treatment of hepatitis C have demonstrated high rates of efficacy, are well tolerated and considered safe. However, they are not free of drug interactions. To describe the effectiveness of hepatitis C treatment and the incidence and severity of potential drug interactions between drugs used during this treatment. A cross-sectional study with 148 patients who began treatment for hepatitis C between April and June 2016 in a specialized center in Brazil. Drug interactions were identified in the Truven Health Analytic/DynaMed Plus and Hep-C Interactions databases. Regarding treatment outcome, 93.9% of patients achieved SVR, 2.7% relapsed and 3.4% did not return after the end of the follow-up period. A total of 328 chronic diseases were identified (71 different diseases), and 88.5% of the patients had at least one chronic disease. The patients reported the use of 474 drugs (121 different drugs), with 3.2 drugs per patient on average. We identified 265 potential drug interactions, classified as important (6.0%), with clinical significance (20.7%) and without clinical significance or with insufficient data (69.4%). Cirrhotic patients had a higher average number of potential drug interactions than non-cirrhotic patients (2.51 x 0.79, p = 0.000). Hepatitis C treatment with direct-acting antivirals are effective and safe for most of patients.
DOI: 10.6084/m9.figshare.19923464
title: An integrated approach to identify bimodal genes associated with prognosis in câncer

description: Abstract Bimodal gene expression (where a gene expression distribution has two maxima) is associated with phenotypic diversity in different biological systems. A critical issue, thus, is the integration of expression and phenotype data to identify genuine associations. Here, we developed tools that allow both: i) the identification of genes with bimodal gene expression and ii) their association with prognosis in cancer patients from The Cancer Genome Atlas (TCGA). Bimodality was observed for 554 genes in expression data from 25 tumor types. Furthermore, 96 of these genes presented different prognosis when patients belonging to the two expression peaks were compared. The software to execute the method and the corresponding documentation are available at the Data access section.
DOI: 10.6084/m9.figshare.19923464.v1
title: An integrated approach to identify bimodal genes associated with prognosis in câncer

description: Abstract Bimodal gene expression (where a gene expression distribution has two maxima) is associated with phenotypic diversity in different biological systems. A critical issue, thus, is the integration of expression and phenotype data to identify genuine associations. Here, we developed tools that allow both: i) the identification of genes with bimodal gene expression and ii) their association with prognosis in cancer patients from The Cancer Genome Atlas (TCGA). Bimodality was observed for 554 genes in expression data from 25 tumor types. Furthermore, 96 of these genes presented different prognosis when patients belonging to the two expression peaks were compared. The software to execute the method and the corresponding documentation are available at the Data access section.
DOI: 10.6084/m9.figshare.19898582
title: Combating corruption as a citizen priority for government action: the case of Chile, 2000-2019

description: Abstract After a theoretical discussion on the determinants of perception of corruption and on the importance people give to fighting corruption as a priority for government action, we postulate 4 hypotheses and we test them for the case of Chile, a democracy with low levels perception of corruption, but with several corruption scandals in recent years. We use 43 (N=63768) national polls conducted by the Center for Public Studies (CEP) between 2000 and 2019 to estimate binary logistic models. The likelihood of mentioning corruption instead of other issues as a priority for government action is lower among people who approve of the president’s performance, higher in those who use more media to get their political information, lower in the first year and higher in the last year of every administration, and lower among those who think crime, employment and other social issues should be a priority for government action.
DOI: 10.6084/m9.figshare.19898582.v1
title: Combating corruption as a citizen priority for government action: the case of Chile, 2000-2019

description: Abstract After a theoretical discussion on the determinants of perception of corruption and on the importance people give to fighting corruption as a priority for government action, we postulate 4 hypotheses and we test them for the case of Chile, a democracy with low levels perception of corruption, but with several corruption scandals in recent years. We use 43 (N=63768) national polls conducted by the Center for Public Studies (CEP) between 2000 and 2019 to estimate binary logistic models. The likelihood of mentioning corruption instead of other issues as a priority for government action is lower among people who approve of the president’s performance, higher in those who use more media to get their political information, lower in the first year and higher in the last year of every administration, and lower among those who think crime, employment and other social issues should be a priority for government action.
DOI: 10.6084/m9.figshare.19898580
title: Political and Party Polarization in United States (1936-2016)

description: Abstract This research is aimed at understanding the supposed US party polarization. Through a methodology that privileges the use of national platforms as an indicative of ideological portrait and gradation indicators, this study aims to empirically show in a historical perspective the approximations and distances between the two most important political parties in USA and, consequently, the rise or decline of ideologies as conservatism and liberalism. The time framed goes from 1936 (first election post New Deal) to 2016. The results indicate that there is a party polarization in recent period, not singular in the history of the country, but unique in the sense that both parties head to extremes of the political spectrum characterized, mainly, by a conservative ascendancy by the Republican Party with regards to social issues. Far from a centrist discourse or not committed supposedly intending to collect a higher number of electors, the US parties define themselves by opposed positionings. One still needs to know if this is a process that benefits democracy when representing society with all its idiosyncrasies or it is one process that harms democracy by contemplating extremes not always characteristics of the society as a whole.
DOI: 10.6084/m9.figshare.19898580.v1
title: Political and Party Polarization in United States (1936-2016)

description: Abstract This research is aimed at understanding the supposed US party polarization. Through a methodology that privileges the use of national platforms as an indicative of ideological portrait and gradation indicators, this study aims to empirically show in a historical perspective the approximations and distances between the two most important political parties in USA and, consequently, the rise or decline of ideologies as conservatism and liberalism. The time framed goes from 1936 (first election post New Deal) to 2016. The results indicate that there is a party polarization in recent period, not singular in the history of the country, but unique in the sense that both parties head to extremes of the political spectrum characterized, mainly, by a conservative ascendancy by the Republican Party with regards to social issues. Far from a centrist discourse or not committed supposedly intending to collect a higher number of electors, the US parties define themselves by opposed positionings. One still needs to know if this is a process that benefits democracy when representing society with all its idiosyncrasies or it is one process that harms democracy by contemplating extremes not always characteristics of the society as a whole.
DOI: 10.6084/m9.figshare.19920796
title: Construction and validation of an in-hospital transport simulation scenario

description: ABSTRACT Objective To build and validate the content of a clinical simulation scenario for teaching in-hospital transport of critically ill patients. Methods A descriptive study of construction and validation of a clinical simulation scenario for teaching in-hospital transport. A scenario based on the literature was built, followed by validation, using the Delphi technique, by five specialists, with an agreement of 80%. The experts were selected through snowball sampling. An instrument was developed containing 26 topics to be assessed for relevance, clarity, objectivity, feasibility, current content, vocabulary, and a field for observations. Results Two rounds were carried out by the specialists to reach a consensus of 80%. According to the experts´ recommendation, the initial scenario was written more clearly and objectively, and divided into two parts: patient preparation and patient transport. Conclusion In this study, the construction and validation of the scenario for teaching in-hospital transport were successfully performed. It may be applied in several services to evaluate the training of nursing undergraduate students, as well as for the professional improvement of those who work in the in-hospital transport service.
DOI: 10.6084/m9.figshare.19920796.v1
title: Construction and validation of an in-hospital transport simulation scenario

description: ABSTRACT Objective To build and validate the content of a clinical simulation scenario for teaching in-hospital transport of critically ill patients. Methods A descriptive study of construction and validation of a clinical simulation scenario for teaching in-hospital transport. A scenario based on the literature was built, followed by validation, using the Delphi technique, by five specialists, with an agreement of 80%. The experts were selected through snowball sampling. An instrument was developed containing 26 topics to be assessed for relevance, clarity, objectivity, feasibility, current content, vocabulary, and a field for observations. Results Two rounds were carried out by the specialists to reach a consensus of 80%. According to the experts´ recommendation, the initial scenario was written more clearly and objectively, and divided into two parts: patient preparation and patient transport. Conclusion In this study, the construction and validation of the scenario for teaching in-hospital transport were successfully performed. It may be applied in several services to evaluate the training of nursing undergraduate students, as well as for the professional improvement of those who work in the in-hospital transport service.
DOI: 10.6084/m9.figshare.19920808
title: Adolescer Saudável: screening and follow-up of risk at school

description: ABSTRACT Objective To characterize adolescents referred to medical consultation based on the screening tool “Perfil de Saúde do Utente Adolescente”, and to compare to information gathered from a questionnaire and data assessed during the visit. Methods A retrospective and descriptive study, with analysis of the questionnaires filled out by adolescents and their respective medical records, in the period from January 2013 to June 2016. Results A total of 54 adolescents were seen, 57% male and mean age of 12±1.7 years. In the questionnaire, 37% stated that they had some kind of health problem; 35% would like to change the relationship with their parents; 18% had some concern about safety at school; and 39% made dietary mistakes. Approximately 31% had consumed alcohol, 13% had tried smoking, and 4% had used other drugs. At the first medical appointment, 38% stated they had chronic disease, 11% reported poor family environment, 39% had school problems and 39% made dietary mistakes. About 13% had tried smoking, 24% had tried to consume alcohol, and 2% had tried other drugs. Thirty seven percent of adolescents were referred to adolescent medicine consultation, and 39% to another hospital consultation. Conclusion Many of the biopsychosocial risk items identified through the questionnaire were confirmed during consultation, indicating that it could be a useful screening method for problems linked to the adolescence period.