DOI: 10.5061/dryad.37pvmcvt7
title: Data from: Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees

description: Lifestyle has widespread effects on human health and aging. Prior results
 from chimpanzees, one of the closest evolutionary relatives of humans,
 indicate that these lifestyle effects may also be shared with other
 species, as semi-free-ranging chimpanzees fed a naturalistic diet show
 healthier values in several specific health biomarkers, compared with
 their sedentary, captive counterparts. Here, we examined how lifestyle
 factors associated with different environments affect rates of
 physiological aging in closely related chimpanzees (Pan
 troglodytes). We compared physiological dysregulation, an index
 of biological aging, in semi-free-ranging chimpanzees in an African
 sanctuary versus captive chimpanzees in US laboratories. If the rate of
 aging is accelerated by a high-calorie diet and sedentism, we predicted
 greater age-related dysregulation in the laboratory populations.
 Conversely, if the costs of a wild lifestyle accelerate aging, then
 semi-free-ranging chimpanzees at the sanctuary, whose environment better
 approximates the wild, should show greater age-related dysregulation. We
 further tested whether dysregulation differed based on sex or body system,
 as in humans. We found that semi-free-ranging chimpanzees showed
 lower overall dysregulation, as well as lower age-related change in
 dysregulation, than laboratory chimpanzees. Males experienced lower
 dysregulation in both contexts, and the two populations exhibited distinct
 aging patterns based on the body system. Our results support the
 conclusion that naturalistic living conditions result in healthier aging
 in chimpanzees. These data provide support for the proposal that lifestyle
 effects on human health and aging are conserved from deeper into our
 evolutionary history.
description: # Data from: Age-related physiological dysregulation progresses slowly in
 semi-free-ranging chimpanzees
 [https://doi.org/10.5061/dryad.37pvmcvt7](https://doi.org/10.5061/dryad.37pvmcvt7) Study Authors: M. Cole, P. Barnes, I. Monroe, J. Rukundo, M. Emery Thompson & A.G. Rosati Contact: [megancole@unm.edu](mailto:megancole@unm.edu) or [rosati@umich.edu](mailto:rosati@umich.edu) ## Description of the data and file structure This data set consists of three data files (.xlsx format) for the different components of the data reported in this work. For each file, there is a key tab in the file defining each variable reported in the main data tab. NAs in these files indicate no available data for that specific measure for that individual in the noted year of sampling. The specific files are: *1. Data - Cole et al - Sanctuary Chimpanzee Biomarkers.* This file comprises the raw biomarker data from the sanctuary-living chimpanzees that were used to derive dysregulation scores from this population. *2. Data - Cole et al - Chimpanzee Physiological Dysregulation.* This file comprises the computed dysregulation scores from both sanctuary-living and lab-living chimpanzees, as computed following the methods described in the main manuscript. This file lists dysregulation scores, z-scored ages, and number of biomarkers for five distinct analyses described and reported in the main manuscript: (1) the primary analysis comprising all appropriate biomarkers from an age-matched sample of sanctuary and laboratory chimpanzees using a site-specific reference sample with a healthy weight cutoff; (2) an analysis using the full available age range of data, specifically incorporating older chimpanzee data from the laboratory populations; (3) an analysis using a pooled (rather than site-specific) reference sample; (4) an analysis using only a subset of common biomarkers available at all sites; and (5) analysis using an alternative (higher) overweight cutoff for the reference sample. *3. Data - Cole et al - Chimpanzee Physiological Dysregulation By Body System.* This file comprises the computed dysregulation scores for specific body systems from both sanctuary-living and lab-living chimpanzees, as computed following the methods described in the main manuscript. ## Sharing/Access information Dysregulation scores for laboratory chimpanzees were derived from biomarker data from these populations. This chimpanzee biomarker data is deposited in the Primate Aging Database and are accessible at: [https://primatedatabase.org/](https://primatedatabase.org/)