cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28624445
title: Supplementary Material for: Deciphering WNT signalling vulnerabilities in soft tissue sarcoma.

description: Introduction: Soft tissue sarcomas (STS) are a group of rare malignancies with limited treatment options and a persistent lack of effective therapies. Despite the heterogeneous nature of STS, the canonical WNT/β-catenin signalling pathway has been associated with sarcomagenesis, and also with the initiation and progression of other cancers. Methods: Eight patient-derived primary cultures representing different STS histological subtypes were characterized by immunohisto(cyto)chemistry, WNT/β-catenin activation, and Next-Generation Sequencing (NGS). Results: Elevated levels of active phospho-β-catenin and its nuclear localization was found in all STS primary cultures, with heterogeneous downstream WNT signaling activation. Genomic analysis of matched STS tumors identified pathogenic or likely pathogenic genetic variants in crucial signaling pathways, including WNT, DNA damage repair and PI3K/AKT/mTOR-MAPK pathways. Interestingly, 50% of STS tumors studied carried genetic variants in PIK3CA and PTEN genes with potential clinical significance, listed as predictive biomarkers of response to specific drugs (FDA-level 3). Conclusions: This study provides valuable insights into WNT signaling vulnerabilities in STS, offering a foundation for the development of targeted therapeutic strategies and the identification of potential biomarkers for personalized treatment approaches in this challenging group of malignancies.
DOI: 10.6084/m9.figshare.28643549
title: Supplementary Material for: Effects of Renal Denervation on Cardiac Remodeling, Cardiac Function, and Cardiovascular Neurohormones in Heart Failure with Reduced Ejection Fraction Patients: A Meta-Analysis and Systematic Review

description: Objective: To evaluate the effects of Renal Denervation (RDN) on cardiac remodeling, cardiac function, and cardiovascular (CV) neurohormones in heart failure patients with reduced ejection fraction (HFrEF).
Methods: We searched PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI), identifying 6 randomized controlled trials (RCTs) and 9 single-arm studies, totaling 352 participants. Meta-analyses for RCTs and single-arm studies were conducted using STATA 17 software and the metafor package in R, respectively. 
Results: In RCTs, RDN significantly reduced left ventricular end-diastolic diameter (LVEDD) (WMD=-3.55 mm, 95% CI [-5.51, -1.59], P&lt;0.01), left ventricular end-systolic diameter (LVESD) (WMD=-4.13 mm, 95% CI [-6.08, -2.18], P&lt;0.01), and significantly increased left ventricular ejection fraction (LVEF) (WMD=6.30%, 95% CI [4.64, 7.96], P&lt;0.01) and 6-minute walk test (6MWT) distance (WMD=51.25 m, 95% CI [8.30, 94.20], P&lt;0.05). brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were significantly reduced (SMD=-1.24, 95% CI [-1.57, -0.90], P&lt;0.01). In single-arm studies, RDN significantly reduced LVEDD (MC=−2.41 mm, 95% CI [-3.74, -1.09], P&lt;0.01), LVESD (MC=−1.72 mm, 95% CI [-2.77, -0.67], P&lt;0.01), LAD (MC=−1.62 mm, 95% CI [-3.16, -0.08], P&lt;0.01), and interventricular septal thickness (IVST) (MC=−0.76mm, 95% CI [-1.05, −0.47], P&lt;0.01). RDN significantly increased LVEF（MC=29.52%, 95% CI [ 12.74, 46.31], P&lt;0.01）and 6MWT distance (MC=100.49 m, 95% CI [49.12, 151.86], P&lt;0.05). RDN significantly reduced BNP or NT-proBNP levels (SMC=−0.57, 95% CI [-0.83, −0.31], P&lt;0.01). Our study also found that RDN had varying degrees of reduction on Renin, Angiotensin II, Aldosterone, and Norepinephrine (NE) in HFrEF patients. Additionally, we found that RDN had no significant effect on SBP/DBP in HFrEF patients, but reduced heart rate (WMD=-7.22 bpm, 95% CI [-9.84, -4.60], P&lt;0.01).
Conclusion: Our meta-analysis demonstrates that RDN can improve cardiac remodeling, enhance cardiac function, reduce CV neurohormones and has no significant effect on blood pressure in patients with HFrEF.
DOI: 10.6084/m9.figshare.28643552.v1
title: Supplementary Material for: Non malignant ACTH-Independent Cushing Syndrome in Pediatric Patients: A Retrospective Observational Cohort Study

description: Purpose: ACTH-independent Cushing’s syndrome (CS) is a rare cause of pediatric CS. Our objective was to describe the features of pediatric ACTH-independent CS and to compare groups defined by etiology. 
Methods: We conducted a retrospective observational study of patients aged 0–18 years at diagnosis between 1992–2022 for ACTH-independent CS in three Paris pediatric hospitals. Additionally, we compared the outcomes of McCune-Albright syndrome (MCAS) patients with CS and without CS. 
Results: Of the 15 patients with CS, seven had MCAS, seven primary pigmented nodular adrenocortical disease (PPNAD) as part of CNC (Carney complex), and one had CS with no etiology found. Age at CS diagnosis was 0,3 year old (0,17;1) in MCAS and 9 years old (5;15) in PPNAD. The MCAS group had more impaired growth retardation (-4,75 SDS in MCAS vs -1 SDS in CNC, p = 0,006) and higher prevalences of intrauterine growth retardation (P=0.01) and liver dysfunction at diagnosis (P=0.04). All seven MCAS patients had learning disabilities vs. only two CNC patients. 12 out of 15 had bilateral adrenalectomy. None of the MCAS patients received Growth hormone therapy, while 4 CNC patients benefited from growth hormon therapy. At end of follow up, growth recovered in both groups, albeit less in the MCAS group (-1,5 SDS in MCAS vs -0,5 SDS in CNC), in which liver dysfunction often persisted. 
Conclusions: ACTH-independent CS is rare but can lead to significant burden in children. Early diagnosis and management are essential. New drugs targeting adrenal steroid synthesis are awaited.
DOI: 10.6084/m9.figshare.28643555
title: Supplementary Material for: Diagnosis of peripheral pulmonary lesions using forceps and 1.1 or 1.7 mm cryoprobes. A randomised trial.

description: Introduction: Lung cancer screening has increased the detection of peripheral pulmonary lesions (PPLs). Accurate diagnosis for therapy and prognosis is crucial but challenging. Our study compares the safety and efficacy of transbronchial cryobiopsy with two probe diameters and forceps biopsy.
Methods: This single-centre, investigator-initiated, open-label, randomised trial included patients with PPLs who required flexible bronchoscopy with radial endobronchial ultrasound-guided biopsy for histopathological diagnosis. Patients received a forceps biopsy and were randomly assigned to a cryobiopsy with a 1.1 mm (freezing time 7-10 sec) or a 1.7mm cryoprobe (freezing time 4-6 sec), respectively. The primary outcome was the diagnostic yield; secondary outcomes included total biopsy size, the proportion of malignant tissue, artefact-free alveolar space percentage, molecular pathology of the specimen and safety.
Results: Fifty-four patients (66.52±9.81 years; 48.1% male) with a median nodule size of 24mm [IQR 19 to 30] were included. The overall diagnostic yield was similar in the 1.1 mm and 1.7 mm groups (75.9% vs. 88.0%, p=0.261), and the specimens obtained with the two different cryoprobes were equal in size, quality, and information about molecular pathology. There was no difference in procedural-related bleeding between the groups (p=0.847). Compared to forceps biopsies, cryobiopsies had a superior overall diagnostic yield (75.9% vs. 48.1%, p=0.001) and were better suited for further molecular analysis (p=0.001). 
Conclusion: The 1.1 mm and 1.7 mm cryoprobes displayed comparable diagnostic yield, ability to provide molecular pathology information, and safety. Forceps biopsy was inferior to cryobiopsy in all aspects except safety.
DOI: 10.6084/m9.figshare.28643540
title: Integrated Energy System

description: The parameters for IES consisting test systems 1 and 2
DOI: 10.6084/m9.figshare.28643540.v1
title: Integrated Energy System

description: The parameters for IES consisting test systems 1 and 2
DOI: 10.15468/dl.kpp33g
title: Occurrence Download

description: A dataset containing 266 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Platycorypha nigrivirga Burckhardt, 1987",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 266 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021731-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.24440487
title: Machine learning approach to predict heat transfer and fluid flow characteristics of integrated pin fin-metal foam heat sink

description: Integrated pin fin-metal foam (PF-MF) heat sink offers enhanced thermal performance owing to the higher surface area and flow mixing. By realizing the strong influence of geometrical parameters of PFs, morphological properties of MF, and coolant hydrodynamics on the thermal-hydraulic performance of the PF-MF heat sink, this article presents a machine learning (ML) surrogated multiparameter and multi-objective optimization framework to determine optimal PF-MF heat sink layouts within the laminar flow regime to enhance the thermal performance of the heat sink with a minimal pumping power penalty. Four supervised regression ML models, namely random forest, extreme gradient boosting, support vector regressor, and artificial neural networks (ANN), were considered while searching for the best surrogate. Four geometrical parameters of PFs, such as PFs diameter (<i>D</i>), height (<i>h</i>), longitudinal pitch, transverse pitch, two morphological properties of MF, i.e., pore density (ω), porosity (ε), and coolant flow condition, i.e., Reynolds number (Re) have been considered as design parameters. The heat transfer and fluid flow performance of the heat sink are evaluated using nondimensional Nusselt number (Nu) and friction factor (f). A high-fidelity 3-D computational fluid dynamics/heat transfer (CFD/HT) model has been developed to evaluate the thermal-hydraulic performance of all PF-MF heat sink layouts. Furthermore, utilizing the numerical data, ML models have been trained and fine-tuned to accurately predict the overall performance of the PF-MF heat sink. Upon testing the prediction and interpolation capability of all considered ML models, ANN outperforms other models, hence, ANN model has been coupled with genetic algorithm (GA) optimizer to identify three different optimized PF-MF heat sink layouts at three different Re. Finally, the result shows that the ANN surrogated GA-optimized PF-MF heat sink layout can improve the overall thermal-hydraulic performance by approximately 19–35% compared to the best PF-MF heat sink layout among the used input feature space for ML model.
DOI: 10.6084/m9.figshare.24440487.v2
title: Machine learning approach to predict heat transfer and fluid flow characteristics of integrated pin fin-metal foam heat sink

description: Integrated pin fin-metal foam (PF-MF) heat sink offers enhanced thermal performance owing to the higher surface area and flow mixing. By realizing the strong influence of geometrical parameters of PFs, morphological properties of MF, and coolant hydrodynamics on the thermal-hydraulic performance of the PF-MF heat sink, this article presents a machine learning (ML) surrogated multiparameter and multi-objective optimization framework to determine optimal PF-MF heat sink layouts within the laminar flow regime to enhance the thermal performance of the heat sink with a minimal pumping power penalty. Four supervised regression ML models, namely random forest, extreme gradient boosting, support vector regressor, and artificial neural networks (ANN), were considered while searching for the best surrogate. Four geometrical parameters of PFs, such as PFs diameter (<i>D</i>), height (<i>h</i>), longitudinal pitch, transverse pitch, two morphological properties of MF, i.e., pore density (ω), porosity (ε), and coolant flow condition, i.e., Reynolds number (Re) have been considered as design parameters. The heat transfer and fluid flow performance of the heat sink are evaluated using nondimensional Nusselt number (Nu) and friction factor (f). A high-fidelity 3-D computational fluid dynamics/heat transfer (CFD/HT) model has been developed to evaluate the thermal-hydraulic performance of all PF-MF heat sink layouts. Furthermore, utilizing the numerical data, ML models have been trained and fine-tuned to accurately predict the overall performance of the PF-MF heat sink. Upon testing the prediction and interpolation capability of all considered ML models, ANN outperforms other models, hence, ANN model has been coupled with genetic algorithm (GA) optimizer to identify three different optimized PF-MF heat sink layouts at three different Re. Finally, the result shows that the ANN surrogated GA-optimized PF-MF heat sink layout can improve the overall thermal-hydraulic performance by approximately 19–35% compared to the best PF-MF heat sink layout among the used input feature space for ML model.
DOI: 10.15468/dl.syj53r
title: Occurrence Download

description: A dataset containing 241 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pristiphora erichsonii (Hartig, 1837)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 241 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021732-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5ft8dx4v
title: MassIVE MSV000097410 - NOZ Coral Reef DOM 2018 collection 2019 analysis
title: Dataset containing multiple sample sets of coral reef associated dissolved organic matter
DOI: 10.15468/dl.gstyem
title: Occurrence Download

description: A dataset containing 38 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Pristiphora abbreviata (Hartig, 1837)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 38 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021733-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3q4w4c
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Launaea intybacea (Jacq.) Beauverd, Leucaena leucocephala (Lam.) de Wit, Opuntia stricta (Haw.) Haw., Tamarix aphylla (L.) H.Karst.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Country is one of (Eritrea)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021734-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.12770/5924fa10-ac45-11de-8853-000086f6a603
title: Bathy-morphologie de la Méditerranée (Medimap, édition 2008, résolution 1000m et 500m)

description: Modèle bathymétrique (MNT) de la Méditerranée. Groupe Medimap.Données de bathymétrie acquises par les sondeurs multifaisceaux au cours des campagnes Almofront.leg1 et Almofront.leg2, Almofront, Bretane, Seamewe2, Heralis, Medee, Anaxiprobe, Almofront2 - leg1 et leg2, Prismed2, Marmara, Fanil, Tvic5 et 6, Progres, Maradja, Blac, Nautinil, Medor-Simed1 / 2 / 3 / 4 / 5, Maradja2, Sardinia, Prisme, Assemblage et Thertou. Intégration des MNT des organismes partenaires.Le pas de la grille est de 1000 mètres et 500 mètres.
DOI: 10.15468/dl.36tg36
title: Occurrence Download

description: A dataset containing 98 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Premnobius cavipennis Eichhoff, 1878",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 98 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021736-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sbas2k
title: Occurrence Download

description: A dataset containing 145 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Ambrosia canescens A.Gray"
 ]
}

 The dataset includes 145 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021735-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vgcydt
title: Occurrence Download

description: A dataset containing 120 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Shorea roxburghii G.Don"
 ]
}

 The dataset includes 120 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021737-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tnvcrj
title: Occurrence Download

description: A dataset containing 1012 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Pterocarpus macrocarpus Kurz"
 ]
}

 The dataset includes 1012 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021739-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u8dg33
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Dendrobium infundibulum Lindl."
 ]
}

 The dataset includes 92 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021740-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hq55a7
title: Occurrence Download

description: A dataset containing 1012 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Pterocarpus macrocarpus Kurz"
 ]
}

 The dataset includes 1012 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021742-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.75xras
title: Occurrence Download

description: A dataset containing 98 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Aceros nipalensis (Hodgson, 1829)"
 ]
}

 The dataset includes 98 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021738-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28643543
title: genome2n_r.fa

description: D. japonica genome
DOI: 10.6084/m9.figshare.28643543.v1
title: genome2n_r.fa

description: D. japonica genome
DOI: 10.15468/dl.a5tgx5
title: Occurrence Download

description: A dataset containing 1012 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Pterocarpus macrocarpus Kurz"
 ]
}

 The dataset includes 1012 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021741-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.spwfr9
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Panthera pardus (Linnaeus, 1758)"
 ]
}

 The dataset includes 58 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021745-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bwvqe6
title: Occurrence Download

description: A dataset containing 340 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Calloselasma rhodostoma (Kuhl, 1824)"
 ]
}

 The dataset includes 340 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021746-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xkab82
title: Occurrence Download

description: A dataset containing 3052 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Grus leucogeranus Pallas, 1773"
 ]
}

 The dataset includes 3052 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021744-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.52rbmt
title: Occurrence Download

description: A dataset containing 1012 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Pterocarpus macrocarpus Kurz"
 ]
}

 The dataset includes 1012 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021747-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dqamvk
title: Occurrence Download

description: A dataset containing 2918011 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "PublishingCountry is China"
 ]
}

 The dataset includes 2918011 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021730-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3ycjsk
title: Occurrence Download

description: A dataset containing 1012 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Pterocarpus macrocarpus Kurz"
 ]
}

 The dataset includes 1012 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021748-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.b7u8tn
title: Occurrence Download

description: A dataset containing 480 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhytidodus decimusquartus (Schrank, 1776)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 480 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021749-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4mxfvy
title: Occurrence Download

description: A dataset containing 712 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Thailand",
 "TaxonKey is Shorea siamensis (Kurz) Miq."
 ]
}

 The dataset includes 712 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021750-250310093411724/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.