cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17044/scilifelab.12482183.v2
title: LNP drug delivery image data

description: Data to accompany the manuscript "Deep learnings models for lipid-nanoparticle-based drug delivery"<br>Abstract:Large-scale time-lapse microscopy experiments are useful to understand delivery and expression in RNA-based therapeutics. The resulting data has high dimensionality and high (but sparse) information content, making it challenging and costly to store and process. Early prediction of experimental outcome enables intelligent data management and decision making. We start from time-lapse data of HepG2 cells exposed to lipid-nanoparticles loaded with mRNA for expression of green fluorescent protein (GFP). We hypothesize that it is possible to predict if a cell will express GFP or not based on cell morphology at time-points prior to GFP expression. Here we present results on per-cell classification (GFP expression/no GFP expression) and regression (level of GFP expression) using three different approaches. In the first approach we use a convolutional neural network extracting per-cell features at each time point. We then utilize the same features combined with: a long-short-term memory (LSTM) network encoding temporal dynamics (approach 2); and time-series feature extraction using the python package tsfresh followed by principal component analysis and gradient boosting machines (approach 3), to reach a final classification or regression result. Application of the three approaches to a previously unanalyzed test set of cells showed good predictive performance of all three approaches but that accounting for the temporal dynamics via LSTMs or tsfresh led to significantly improved performance. The predictions made by the LSTM and tsfresh applications were not significantly different. The results highlight the benefit of accounting for temporal dynamics when studying drug delivery using high content imaging.<br>Python code:https://github.com/pharmbio/phil_LNP_modelling<br><br><br><br><br><br>
DOI: 10.6084/m9.figshare.22559599.v2
title: Larger Black Carp Prefers Lower Satiation for An Active Post-Prandial Movement Regulation in An Unfamiliar Environment

description: There are all raw data and original code calculated and analyzed in this study.
DOI: 10.17632/mhcsf96tz4
title: Exploring the Integration of Informed Machine Learning in Engineering Applications: A Comprehensive Review

description: Integrating Artificial Intelligence (AI) and Machine Learning (ML) into mechanical engineering catalyzes a transformative shift within Industry 4.0, offering unprecedented opportunities for innovation, efficiency, and problem-solving. This paper explores the pivotal role of AI and ML in reshaping mechanical engineering practices, from predictive maintenance and design optimization to quality control and supply chain management. By leveraging sophisticated algorithms and vast datasets, AI and ML enable mechanical systems to achieve higher autonomy, performance, and reliability levels. However, adopting these technologies also presents challenges, including technical hurdles, ethical considerations, and the need for specialized knowledge. Through a series of case studies, the paper illustrates successful implementations of AI and ML in mechanical engineering projects, highlighting the benefits and addressing the limitations encountered. Furthermore, it discusses the evolving role of mechanical engineers in this new landscape, emphasizing the importance of continuous learning and interdisciplinary collaboration to harness the full potential of AI and ML in Industry 4.0. The paper concludes with a forward-looking perspective on future research directions, underscoring the critical role of ethical AI and the development of robust algorithms to navigate the complexities of real-world applications.
DOI: 10.17632/7tz4t7cd8c
title: Data for "In-Situ Determination of Thermoelastic Properties of Magnesite at High Pressure and Temperature with Implications to Seismic Detectability of Moderately Carbonated Lithologies in the Earth’s Mantle"

description: Experimental data for paper "In-Situ Determination of Thermoelastic Properties of Magnesite at High Pressure and Temperature with Implications to Seismic Detectability of Moderately Carbonated Lithologies in the Earth’s Mantle" by Xu et al., submitted to JGR-Solid Earth for consideration of publication.
DOI: 10.6084/m9.figshare.28683068.v1
title: supplementary material.zip

description: The effect of supplementing creatine on CAC
DOI: 10.17632/ws34469r9x
title: The mineralogical and VNIR spectroscopic characteristics of different stages of kaolinized nontronite 

description: This database includes mineralogical and VNIR spectroscopic characteristics of different stages of kaolinized nontronite.  A series of kaolinized nontronite samples were prepared by converting nontronite to kaolinite with different experimental durations. XRD analysis was performed on a Rigaku MiniFlex-600 X-ray diffractometer with Cu/Kα radiation and a Ni filter operating at a current of 15 mA and voltage of 40 kV. SEM images were obtained using an Analytical Scanning Electron Microscope (TESCAN MIRA 3) equipped with an energy dispersive X-ray spectrometer (EDS) operated at an accelerating voltage of 20 kV and working distance (WD) of 15-16 mm.  TG analyses were conducted on a Netzsch STA 409PC instrument. VNIR reflectance spectroscopy spectra were acquired at wavelengths from 350–2500 nm using an Analytical Spectral Devices (ASD) Terraspec-4 spectrometer.
DOI: 10.6084/m9.figshare.21360480.v1
title: Metastases.xlsx

description: Raw data from measurements of morphometric and BAP-1 expression variables in metastatic uveal melanoma.
DOI: 10.17632/5kmd69g767
title: Naphthalene–stilbenes as effective visible-light sensitizers to study the effect of diluent and nanofillers on in situ photopolymerization and 3D-VAT printing process

description: This study presents novel photoinitiating systems based on diaryliodonium salt (IOD) and 1-amino-4-methyl-6-styrylnaphthalene-2-carbonitrile derivatives developed as universal IOD photosensitizers. These systems' spectroscopic characteristics, electrochemical behavior, and thermodynamic parameters were investigated to determine the optimal two-component photoinitiating system for light-initiated polymerization, including free-radical and cationic reactions. This versatility in initiating both types of reactions was utilized to explore the dilution effect of non-reactive and two different reactive (cationic, free-radical) diluents. The best formulation was chosen according to Fourier-transform infrared spectroscopy (FTIR), photorheology, thermogravimetric analysis (TGA), and dynamic mechanical analysis (DMA) and tested for the preparation of functional nanocomposites with two types of nanofiller: silver oxide (Ag2O) and hydroxyapatite (HA). The manufacturing process based on additive technology was analyzed according to FTIR spectroscopy and viscosity changes. The results show the high potential of the newly developed photosensitizers in practical applications and 3D-VAT printing.
DOI: 10.17632/dk3vwtwfpk
title: In silico screening-based discovery of benzamide derivatives as inhibitors of Rho-associated kinase-1 (ROCK1)

description: As a pivotal node in modulating various cell behaviors, Rho-associated kinase-1 (ROCK1) has attracted significant attention as a promising therapeutic target in a variety of diseases. Benzamide has been widely reported as a ROCK1 inhibitors in recent years. To better understand its pharmacological properties and to explore its potential inhibitors, a series of ROCK1 inhibitors derived from N-methyl-4-(4-pyrazolidinyl) benzamides (MPBs) were investigated by using three-dimensional quantitative structure-activity relationship (3D-QSAR) models, pharmacophore models, molecular docking, and molecular dynamics (MD) simulation. The comparative Molecular Field Analysis (CoMFA) model (q2 = 0.616, R2 = 0.972, ONC = 4, and r2pred = 0.983) and the best Comparative Molecular Similarity Indices Analysis (CoMSIA) model (q2= 0.740, R2 = 0.982, ONC = 6, and r2pred = 0.824) exhibited reliable predictability with satisfactory validation parameters. In the subsequent virtual screening, VS03 and VS05 were identified to have superior predicted activities and higher docking scores, meanwhile they demonstrated to be reasonably stable in the binding pocket through MD simulations. These results provide a significant theoretical direction for the rational design and development of novel ROCK1 inhibitors.
DOI: 10.17632/hs4rtk9np9
title: Young families of asteroids

description: Proper orbital elements of asteroids belonging to young families.

In files, the proper orbital elements are given for the asteroid families: major semi-major axis a_p, eccentricity e_p, sine of inclination sin i_p, mean motion n, proper frequencies of pericenter g and node s. The headings of the tables indicate the values of K_1 and K_2 corresponding to the given proper elements.

The study was funded by the Russian Science Foundation grant No. 24-22-00143, https://rscf.ru/en/project/24-22-00143/
DOI: 10.17632/z3fs69mtff
title: Data for: Temporal Pass Plots: an intuitive method for visualising activity patterns of bats and other vocalising animals

description: This folder contains BatClassify results files used to create Temporal Pass Plots in the accompanying article Fig. 2 (Richmond_Myotis_BatClassify_Results.csv), Fig. 3a (Richmond_Ppyg_Site_A_BatClassify_Results.csv) and Fig. 3b (Richmond_Ppyg_Site_B_BatClassify_Results.csv). All other files are used in the TPP vignette, which is provided in the supplementary material.
DOI: 10.6084/m9.figshare.28721966.v1
title: ANES

description: <pre>Logistic regression model for American National Election Studies (ANES) data. The model aims to predict voter intention for Clinton based on party identification and its interaction with age. <br><br></pre>
DOI: 10.17632/79xc6bkgjt
title: Open Innovation Generated Robotic Design and Solver Characteristics Dataset

description: This repository entry should be viewed in conjunction with the Data in Brief explainer "Linking solver characteristics, solving processes and solution attributes: A data explainer for an Open Innovation Generated Robotic Design Dataset" which documents the research design and implementation process and provides a detailed explanation of each data record, carefully characterizing potential limitations associated with research design choices.

Between 2017 and 2020, a team of researchers from the George Washington University collaborated with NASA and Freelancer.com to design and launch the “Astrobee Challenge Series,” a large-scale field experiment that aimed to generate data to characterize the relationship between how a technical problem is formulated and who is able and willing to solve, and the quality of solutions they generate. The core experimental manipulation was of the architecture of the problem posed; the typical open innovation process was instrumented to collect unusually rich data but otherwise untouched. In all, 17 individual contests were run over a period of 12 months. Over the course of the challenge series, we tracked a population of 16,249 potential solvers, of which 6,219 initiated solving, and a subset of 147 unique solvers submitted 263 judgeable solutions. The resultant dataset is unique because it captures demographic and expertise data on the full population of potential solvers and links their activity to their solving processes and solution outcomes. Moreover, in addition to winning designs (the typical basis of analysis), it captures design outcomes for all submitted design artifacts allowing analysis of the variety of solutions to the same problem. This data should be useful for researchers interested in studying the design and innovation process, particularly those focused on novelty, variety, feasibility of solutions or expertise, diversity and capability of solvers.
DOI: 10.17632/8h8zggfnrh
title: Towards High Performance Flexible Planar Supercapacitors

description: data manuscript
DOI: 10.17632/bvwszmbgd7
title: Data for: Virtue Signaling: Using Risk Preferences to Signal Trustworthiness

description: Contains code and notation for all analysis used in the main text of the paper
DOI: 10.17632/dc24z78ht9
title: Sudden Stops and Reserve Accumulation in the Presence of International Liquidity Risk

description: Replication files for "Sudden Stops and Reserve Accumulation in the Presence of International Liquidity Risk".
DOI: 10.17632/wxm9p2fhjt
title: Predicting Rice Phenotypes with Meta and Multi-Target Learning

description: Rice genotype and phenotype data. The genotype data has ~12,000 features and the phenotype data has twelve traits.
DOI: 10.17632/86d5skkjcb
title: Data for: Equity analysis in access to Public Transport through a Land Use Transport Interaction Model. Application to Bucaramanga Metropolitan Area-Colombia.

description: The database obtained in the present investigation came from 5 specific documents and a web page. These documents are: 1. Previous research on the Bucaramanga Metropolitan Area, Manrique, J., Jimenez, C., & Salas, M. (2020). Accesibilidad: Elemento Fundamental para la ejecucion de infraestructura de transporte. Infraestructura Vial, 21(37), 1 - 11. doi:10.15517/IV.V21I37.32884 2. Plan of territorial organization of the Municipality of Bucaramanga, Alcaldia de Bucaramanga. (2014). Plan de Ordenamiento Territorial . Retrieved Noviembre 05, 2019, from https://www.bucaramanga.gov.co/la-ruta/ordenamiento-territorial 3. Plan of territorial organization of the Municipality of Floridablanca, Alcaldia de Floridablanca. (2018). Plan de Ordenamiento Territorial . Retrieved Noviembre 05, 2019, from http://www.floridablanca.gov.co/Transparencia/Paginas/Planeacion.aspx 4. Plan of territorial organization of the Municipality of Giron, Alcaldia de Giron. (2010). Plan de Ordenamiento Territorial . Retrieved Noviembre 05, 2019, from http://www.giron-santander.gov.co/Transparencia/Paginas/Planeacion 5. Plan of territorial organization of the Municipality of Piedecuesta. Alcaldia de Piedecuesta. (2017). Plan de Ordenamiento Territorial. Retrieved Noviembre 05, 2019, from http://www.alcaldiadepiedecuesta.gov.co/Transparencia/Paginas/Planes-Programas-y-Proyectos.aspx The web site that provided us with the greatest primary information was from the National Administrative Department of Statistics (DANE) of Colombia. https://www.dane.gov.co/index.php/ estadisticas -por-tema/ In the same way, it was necessary to complement the information obtained from the transport model using the Visum software.
DOI: 10.17632/hbpfsvzbxk
title: EtalonDx_KissingSpines_WBST155

description: Genotypes and Kissing Spines grades of 155 stock-type (American Quarter Horse, American Paint Horse and Appaloosa) and Warmblood (American Warmblood, Dutch Warmblood, Hanoverian, Belgian Warmblood, Irish Sport Horse, Westphalian, Zangersheide, etc.) horses presented at collaborating veterinary clinics and hospitals, phenotyped using a strict clinical and radiographical scheme to grade each horse from 0 for unaffected controls to 4 for severe KS. Genotypic data resulting from the Illumina Equine SNP70 array (Illumina, Inc.), filtered by minor allele frequency (MAF) higher than 5% and a per locus genotyping rate higher than 95%, resulting in 7,817 and 11,518 respective markers removed, leaving a total of 61,229 markers at a genotyping rate of 0.991564 for the 155 horses.
DOI: 10.17632/jp7vc8tf7w
title: Wind Tunnel Experimental Data for Flow Characteristics above the Roof of Isolated High-rise Building for Wind Energy Harvesting Considering Two Shapes of the Roof, Flat Roof and Deck Roof

description: This data presents an experimental investigation carried out in a Boundary Layer Wind Tunnel located at Ruhr University Bochum, Germany. The flow field is measured above the rooftop of a high-rise building with a square cross-section considering two different roof shapes, flat roof and deck roof. The height-to-width ratio of the building was 1:3. The main purpose is to be used for estimation of urban wind energy potential, and besides for future validation of computational fluid dynamic simulations. Besides velocity field, measured at mainly three positions above the roof, the roof surface pressure was also measured. The flow above the roof was measured for different wind angles: 0°, 15°, 30°, and 45°.
DOI: 10.17632/k2prx886jz
title: Geotechnical data synthesis for GIS-based fault zone analysis: Geodatabase, downtown San Diego, CA

description: Includes an ESRI ArcMap project (created with version 10.2.2) with geotechnical data from the downtown San Diego region. Data include CPT logs, boring logs, trench logs, cross section logs, hand auger logs, seismic logs, and test pit logs. The 268 reports included in the study yielded a total of 2,020 georeferenced data points. These data points are made up of five seismic lines, six hand auger locations, 54 test pit locations, 189 cross section locations, 290 CPT locations, 554 trench locations, and 922 boring locations. Data were used to map fault zones and assign hazard classification. For full description of project contents see the included metadata file. For a full description of the project methods, results, and discussion please see: Weidman, L. C., 2017, Assessing the Rose Canyon fault zone architecture, downtown San Diego, California: Geotechnical data synthesis [M.S. Thesis], San Diego State University, 70 p. and Weidman, L., Maloney, J., Rockwell, T., 2019, Geotechnical data synthesis for GIS-based analysis of fault zone geometry and hazard in an urban environment, Geosphere, v. 15, doi: 10.1130/GES02098.1
DOI: 10.6084/m9.figshare.21568716.v5
title: Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) checklist and flow diagram

description: PRISMA-P Checklist PRISMA flow diagram
DOI: 10.17632/rsn78z2bnp
title: Moringa oleifera Lam. peptide remodels intestinal mucosal barrier by inhibiting JAK-STAT activation and modulating gut microbiota in colitis

description: Untargeted metabolome raw data from mouse serum
DOI: 10.6084/m9.figshare.12967970.v1
title: Supplementary material - Ardeche Tracks

description: 3D models and DEMs for Dinosaur Tracks related to the article published in Palaios: <b>TRACKING DINOSAURS IN COARSE-GRAINED SEDIMENTS FROM THE UPPER TRIASSIC OF ARDÈCHE (SOUTHEASTERN FRANCE)</b> LEO SZEWCZYK, EMMANUELLE VENNIN, JEAN-DAVID MOREAU, GEORGES GAND, MICHEL VEROLET, NICOLAS KLEE AND EMMANUEL FARA<br>
DOI: 10.6084/m9.figshare.7398527.v1
title: Supplementary Material for: Long Non-Coding RNA H19 Acts as an Estrogen Receptor Modulator that is Required for Endocrine Therapy Resistance in ER<sup>+</sup> Breast Cancer Cells

description: <b><i>Background/Aims:</i></b> Blocking estrogen signaling with endocrine therapies (Tamoxifen or Fulverstrant) is an effective treatment for Estrogen Receptor-<i>α</i> positive (ER<sup>+</sup>) breast cancer tumours. Unfortunately, development of endocrine therapy resistance (ETR) is a frequent event resulting in disease relapse and decreased overall patient survival. The long noncoding RNA, <i>H19</i>, was previously shown to play a significant role in estrogen-induced proliferation of both normal and malignant ER<sup>+</sup> breast epithelial cells. We hypothesized that <i>H19</i> expression is also important for the proliferation and survival of ETR cells<i>.</i> <b><i>Methods:</i></b> Here we utilized established ETR cell models; the Tamoxifen (Tam)-resistant LCC2 and the Fulvestrant and Tam cross-resistant LCC9 cells. Gain and loss of <i>H19</i> function were achieved through lentiviral transduction as well as pharmacological inhibitors of the Notch and c-Met receptor signaling pathways. The effects of altered <i>H19</i> expression on cell viability and ETR were assessed using three-dimensional (3D) organoid cultures and 2D co-cultures with low passage tumour-associated fbroblasts (TAFs). <b><i>Results:</i></b> Here we report that treating ETR cells with Tam or Fulvestrant increases <i>H19</i> expression and that it’s decreased expression overcomes resistance to Tam and Fulvestrant in these cells. Interestingly, <i>H19</i> expression is regulated by Notch and HGF signaling in the ETR cells and pharmacological inhibitors of Notch and c-MET signaling together significantly reverse resistance to Tam and Fulvestrant in an <i>H19</i>-dependent manner in these cells. Lastly, we demonstrate that <i>H19</i> regulates <i>ERα</i> expression at the transcript and protein levels in the ETR cells and that <i>H19</i> protects ERα against Fulvestrant-mediated downregulation of ERα protein. We also observed that blocking Notch and the c-MET receptor signaling also overcomes Fulvestrant and Tam resistance in 3D organoid cultures by decreasing ERα and <i>H19</i> expression in the ETR cells. <b><i>Conclusion:</i></b> In endocrine therapy resistant breast cancer cells Fulvestrant is ineffective in decreasing ERα levels. Our data suggest that in the ETR cells, <i>H19</i> expression acts as an ER modulator and that its levels and subsequently ERα levels can be substantially decreased by blocking Notch and c-MET receptor signaling. Consequently, treating ETR cells with these pharmacological inhibitors helps overcome resistance to Fulvestrant and Tamoxifen.
DOI: 10.6084/m9.figshare.27180441.v1
title: Arabic language research papers on AI in journalism

description: The use of AI in journalism in the MENA region. Arabic language research papers
DOI: 10.17632/2zwxbccrck
title: THE RISE AND IMPACT OF MARGINALISED LITERATURE IN MODERN INDIAN LITERATURE

description: Abstract :
Modern Indian literature has witnessed a significant rise in works that focus on the experiences of socially marginalised groups such as Dalits, Adivasis, and women. This genre, rooted in the socio-political movements of marginalised communities, has gained considerable traction among readers and scholars alike. Through oral narratives, autobiographical accounts, and translations, these voices have found a platform in contemporary literary discourse. This article explores the emergence, mechanisms, and impact of marginalised literature in India, highlighting its role in addressing identity, social prejudice, and economic marginalisation while fostering cultural recognition and social realism.

Keywords : Marginalised literature, Dalit literature, Adivasi literature, Feminist literature, Social realism.

Introduction : 
Modern Indian literature has experienced a surge in narratives that spotlight the social realities of marginalised communities, including Dalits, Adivasis, and women. This genre, often referred to as marginalised literature, has carved out a significant space in the literary landscape by presenting stories from the perspectives of those who have historically been oppressed and excluded. These narratives not only reflect the cultural and traditional heritage of these groups but also engage with contemporary socio-political issues, providing a voice to the voiceless. This article delves into the rise of marginalised literature, examining its origins, evolution, and the critical role it plays in modern Indian literature.
DOI: 10.6084/m9.figshare.21781916.v1
title: Supplement to: "Releasing global forests from management : how much more carbon could be stored?"

description: Here we provide the data that was produced for the paper "Releasing global forests from management : how much more carbon could be stored?". The scripts that produced these results can be found through the following link: https://github.com/jasperroebroek/biomass_carrying_capacity. Note that the file expected_biomass.tif corresponds to biomass carrying capacity described in the paper.