cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.27283545.v1
title: Supplementary Material for: Construction of a hybrid vaccine based on Der f 35-derived peptides with reduced allergenicity

description: Introduction
House dust mite is the primary trigger of allergic respiratory diseases worldwide, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in clinic. The use of allergen molecules instead of extracts is a promising strategy in AIT. In the study, we constructed a peptide hybrid vaccine against the major mite allergen Der f 35 and verified its hypo-allergenicity to be a promising candidate for AIT of mite allergy. 
Methods
The gene encoding Der f 35 was retrieved and synthesized. The hypoallergenic peptide fragments derived from the B-cell epitopes were synthesized based on the predicted profiles of B-cell or helper T cell epitopes in Der f 35, they were verified by Immunoglobulin E (IgE)-reaction test and fused to non-allergenic protein carrier to form the hybrid vaccine. Both the wild-type Der f 35 and the designed vaccine were expressed in Escherichia coli and purified by chromatography, their IgE-binding activity was compared by indirect enzyme-linked immunosorbent assay (ELISA), Western blot, inhibition ELISA and basophil activation test (BAT). The blocking immunoglobulin G (IgG) against the designed vaccine was raised in rabbits and its ability to inhibited IgE-binding of Der f 35 was evaluated by ELISA. The vaccine's effects on peripheral blood mononuclear cells (PBMCs) were investigated.
Results
A total of 29 out of 60 (48.33%) IgE-positive sera against Der f 35 were screened. Five peptide fragments (residue 39-42, 60-67, 73-107, 111-118, 126-143) from Der f 35 were selected as candidates, in which four peptides exhibited almost no IgE-reactivity and the fragment 73-107 had weak reaction. Only 5.98-24.02% inhibition rates could be achieved by the peptides when compared with Der f 35 (97.07%). The designed vaccine migrated at approximately 30 kDa by SDS-PAGE. The IgE-ELISA revealed a significant reduction in IgE-binding activity to the vaccine when compared to wild-type Der f 35 (p &lt; 0.0001), the decreased allergenicity were further confirmed by IgE-Western blot, inhibition ELISA and BAT, respectively. The IgE-reactivity of Der f 35 could be blocked by the vaccine induced IgG (p &lt; 0.01). The levels of IL-5 and IL-13 from PBMCs were significantly decreased after stimulation by the vaccine than that by Der f 35 (p &lt; 0.05).
Conclusion
The designed B-cell epitope vaccine of Der f 35 showed greatly diminished allergenicity and Th2 activity. It could be an effective and safety candidate to prevent the allergic adverse reactions during the immunotherapy of mite allergy and merits the further study.
DOI: 10.17632/rnncsh6rgt
title: Replication Data for: The effects of virtual reality travel on satisfaction and visiting intention utilizing an extended stimulus-organism-response theory: Perspectives from Thai tourists

description: This dataset includes replication data for the paper "Sann, R., Luecha, P. and Rueangchaithanakun, R. (2023), "The effects of virtual reality travel on satisfaction and visiting intention utilizing an extended stimulus-organism-response theory: perspectives from Thai tourists", Journal of Hospitality and Tourism Insights, Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/JHTI-05-2023-0321".
DOI: 10.6084/m9.figshare.155784.v1
title: Gaussian Job Archive for C19H28N9O10P

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.17632/x8z7fm48z4
title: Research on High Performance HRM Practices In Indonesian Public Sector from Millennials Perspective

description: The study aims to investigate the impact of high-performance human resource practices (HPHRP) on innovative work behavior (IWB), job satisfaction (JS), and organizational commitment (OC) among millennials in the Indonesian public sector.
DOI: 10.21233/t5n1-qb59
title: Bayan Lake ostracode surface sample dataset

description: Raw data for the Bayan Lake ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
DOI: 10.17632/2n34bxsswr
title: Data from: Evaluation of extraction methods for the recovery of vertebrate DNA from spider webs

description: eDNA sequence data obtained form DNA extraction tests run on bulk spider web sample for the recovery of vertebrate DNA. Raw sequencing results (fastq) and information for demultiplexing reads (.txt) to assess DNA extraction methods. Metadata also included for analysis.
DOI: 10.17632/9v5bw5zr9j
title: Spatially and temporally resolved metabolome of the oral human cavity, negative ionization mode, batch 2

description: BACKGROUD: Saliva samples (#159) from 20 healthy volunteers, including ten males and ten females was analyzed using a semi-targeted LC-MS/MS platform. 
SAMPLE NAMES: 
Structure: [polarity]_[batch]_[sample type]_[subject id]_[time of collection]_[oral location]_[injection number].
explanation: Polarity (neg = negative, pos = positive), batch (1, 2), sample type (blank, QC, sample), time (M = morning, A = afternoon, E = evening), oral location (AT = above the tongue, BT = below the tongue, CK = cheek)
Note: When subject id, time of collection, and oral location for blank and QC sample type are equal to 0. 
RESULTS: Many the metabolites that exhibit heterogeneous distribution, several important metabolites are linked to oral health, such as N-acetylated metabolites, L-ornithine, saccharides, and guanosine monophosphate. Next to the spatial distribution of metabolites, we identified known and novel time dependencies. Among the novel diurnal metabolites, N-acetyl methionine, N,N,N-trimethyl lysine, and N-acetyl tryptophan revealed diurnal patterns in all oral locations. Where the former two behave similarly to cortisol, and the latter has its nadir in the M. Moreover, a pool of amino acids and mono-phosphorylated nucleotides manifested a significant diurnal rhythm exclusively in BT.
DOI: 10.6084/m9.figshare.27957855.v1
title: DATA SET - New Panel for Diagnosing Intestinal Tuberculosis Disease

description: World Health Organization (WHO) reported through the Global Tuberculosis Report 2022 that Indonesia is in 2nd place with the highest burden of tuberculosis (TB) in 2021 after India. Intestinal tuberculosis (ITB) as part of TB has a prevalence of around 3–16%. The clinical manifestations, radiological features, and histopathology of ITB resemble other gastrointestinal diseases, such as inflammatory bowel disease (Crohn's disease and ulcerative colitis), and colon cancer, making it a challenge in efforts to develop a noninvasive laboratory panel for diagnosing ITB with various laboratory biomarkers. We present data related to laboratory findings and clinical manifestation for ITB diagnosis
DOI: 10.17632/74d9cyrv4m
title: TN Prediction Results for Miho Stream Watershed using SWAT-DL

description: # SWAT-ML and Deep Learning Model Results for TN Prediction in Miho Watershed

This dataset contains simulation results and training datasets related to the prediction of Total Nitrogen (TN) concentrations using a hybrid SWAT-ML model and deep learning models (LSTM, GRU) for the Miho watershed.

## 1. Files Included

### [A] SWAT-ML Model Results (Outlet)
- tn_train_pred_0323.csv: Training period predictions for TN at the outlet.
 - Columns: Date2, TN
- tn_test_pred_0323.csv: Testing period predictions for TN at the outlet.
 - Columns: Date2, TN

### [B] Model Input Dataset
- Miho10_dataset_mod.csv: Input dataset used for training the SWAT-ML model. Includes input features such as SWAT outputs and previous precipitation.
 - Columns: Date, SWAT_Flow, SWAT_Sed, SWAT_ORGN, SWAT_ORGP...

### [C] LSTM Model Results (Node-wise)
- Miho3_results_LSTM.csv: LSTM-based TN prediction results at Miho3 site.
 - Columns: Unnamed: 0, org, pred
- Miho5_results_LSTM.csv: LSTM-based TN prediction results at Miho5 site.
 - Columns: Unnamed: 0, org, pred
- Miho6_results_LSTM.csv: LSTM-based TN prediction results at Miho6 site.
 - Columns: Unnamed: 0, org, pred
- Miho9_results_LSTM.csv: LSTM-based TN prediction results at Miho9 site.
 - Columns: Unnamed: 0, org, pred

### [D] GRU Model Results (Node-wise)
- Miho3_results_GRU.csv: GRU-based TN prediction results at Miho3 site.
 - Columns: Unnamed: 0, org, pred
- Miho5_results_GRU.csv: GRU-based TN prediction results at Miho5 site.
 - Columns: Unnamed: 0, org, pred
- Miho6_results_GRU.csv: GRU-based TN prediction results at Miho6 site.
 - Columns: Unnamed: 0, org, pred
- Miho9_results_GRU.csv: GRU-based TN prediction results at Miho9 site.
 - Columns: Unnamed: 0, org, pred

## 2. Notes
- All prediction results are saved in CSV format, containing at least a Date column and predicted TN values.
- This dataset is part of a study on integrating process-based models (SWAT) with machine learning (ML/DL) models to improve nitrogen load prediction accuracy across multiple locations in a watershed.

## 3. Contact
For questions regarding the dataset, please contact:

**Yongeun Park** 
Professor. Department of Civil and Environmental Engineering, 
Konkuk University-Seoul, Republic of Korea 
Email: yepark@konkuk.ac.kr
DOI: 10.17632/7d9byh5z8s
title: Women and Property 1785-1789 Females Only by Marital Status: North Riding Register of Deeds

description: Research hypothesis was to use the Registers of Deeds for the North Riding of Yorkshire (held at North Yorkshire County Record Office, Northallerton, England) to advance knowledge about women's involvement with property transfer and the wider property market in the 18th & 19th centuries. Registers began in 1736 and ceased in 1970; there are 89 Index Ledgers and 2,328 Deeds Registers. The system for recording data changed in 1885 so one Index Ledger was selected from pre/ post this date and 100 years apart to incorporate impact of Marriage Acts. Stage 1 - Two Index Ledgers were transcribed in full: 1) Index of Lands Vol 9 (1784-90) covers a seven-year period and contains 6,868 unique transactions (31,966 lines); and 2) Index of Lands 1885-1889 covers a five-year period and contains 14,481 unique transactions (52,741 lines). Each line represents a person's name. Core data from Index showed Township, unique reference and names of parties, but the 18th century Index Ledger did not show date of transaction or all parties. To analyse by gender this information was required so was added by using the Deeds Registers. Information from the individual Deeds Registers was then used to add to the core datasets: Stage 2 - The gender of all parties ('male', 'female' and 'not applicable' (for businesses) was added. Stage 3 - The usual residence, occupation (if any), marital status and any details of family relationships or inheritance rights of every women was added. Stage 4 - The 18th century dataset was then reduced to a five-year period covering 1785-1789 ONLY to provide a direct comparison with the 19th century dataset. Comparative analysis by: gender, marital status and number of transactions. 1785-1789 findings include: distinctive patterns of female property involvement by gender and marital status. Married women represent more than 50% of female transactions despite having little, if any, legal status (coverture). Although 2,086 women transacted during this period, only 1.39% did so without husband's involvement; this increased to 45.47% by 1885-1889 period, reinforcing that Married Women's Property Acts were beginning to make an impact, treating married women as if 'feme sole'. More parity of involvement across marital status groups in 1885-1889 data, with spinsters' involvement increasing the most (from 17.58% to 31.37%). ** This dataset is the subset of 4,101 women named in the Index Ledger - sorted by Marital Status.**
DOI: 10.17632/j3gtjywky6
title: RailWay File Repository

description: Real World Instances for Train Timetabling Problem (TTP) available in https://github.com/ehfp/ttp/
DOI: 10.6084/m9.figshare.3531605.v1
title: Appendix A. Published studies included in the meta-analysis.

description: Published studies included in the meta-analysis.
DOI: 10.17632/mcstr2mgt7
title: Data for: Novel siadenovirus infection in a cockatiel with chronic liver disease

description: This is a 4823 nucleotide segment which corresponds to the cleanest read following bioinformatics analysis. This segment contains the complete hexon gene as well as complete pVI, pVII, pX genes and partial sequences of the penton and protease genes of an avian siadenovirus. The sequence was derived from a pooled liver and kidney homogenate from a cockatiel with chronic liver disease.
DOI: 10.17632/y4w2nrrw2n
title: Supplementary Material for An alternative regularization approach for modelling regional lithospheric magnetic field from satellite magnetic measurements by spherical equivalent source method and its application in Africa

description: This supporting information provides the figures of experimental results related to the spherical equivalent source model used in this study, with detailed descriptions given in each figure.
DOI: 10.6084/m9.figshare.3568206.v1
title: Appendix C. Mean biomass of understory taxa in WS1 and WS3, H. J. Andrews Experimental Forest, Oregon, over the study period (1979–2008).

description: Mean biomass of understory taxa in WS1 and WS3, H. J. Andrews Experimental Forest, Oregon, over the study period (1979–2008).
DOI: 10.17632/ddnfz7rn94
title: Auditor Going Concern Opinion

description: The auditor's reporting of the going concern opinion (GCO) on Firms
DOI: 10.6084/m9.figshare.21632180.v1
title: snp dataset of medicago

description: snp dataset of two closely related medicago species
DOI: 10.17632/9x9xph4v46
title: Engram Stability and Maturation During Systems Consolidation

description: All data points describing the results in the 'Engram Stability and Maturation During Systems Consolidation' manuscript, divided by Figures.
DOI: 10.6084/m9.figshare.28789721.v1
title: Study on the related targets and molecular mechanism of Xiaojianzhong decoction and gastric cancer.docx

description: This study aims to deeply explore the potential molecular mechanisms of Xiaojianzhong Decoction in the treatment of gastric cancer by means of network pharmacology and molecular docking techniques, combined with bioinformatics analysis methods. The RNAseq data of gastric cancer were obtained from the UCSC Xena database, and the differentially expressed genes between gastric cancer tissues and normal tissues were screened out. The main components and their targets of Xiaojianzhong Decoction were obtained from the BATMAN-TCM 2.0 database, and then the associated targets between Xiaojianzhong Decoction and gastric cancer were screened out. The protein-protein interaction (PPI) network was constructed with the help of the STRING database, and the key targets were screened out for functional enrichment analysis. Finally, molecular docking technology was used to verify the binding activity between the key targets and the components of Xiaojianzhong Decoction. The research results showed that a total of 2,544 significantly upregulated genes and 420 significantly downregulated genes were screened out, and there were 250 associated targets between Xiaojianzhong Decoction and gastric cancer. The PPI network analysis indicated that CCND1, CXCR4, and FN1 were the core targets. The functional enrichment analysis pointed out that these targets were mainly involved in pathways such as the cell cycle, inflammatory response, and immune regulation. The molecular docking results showed that the main components of Xiaojianzhong Decoction had strong binding activity with the core targets. In conclusion, Xiaojianzhong Decoction may affect the cell cycle, inflammatory response, and immune microenvironment by regulating targets such as CCND1, CXCR4, and FN1, thereby exerting an anti-gastric cancer effect.
DOI: 10.25444/nhlbi.14519436.v1
title: PREM images supporting data in figure 4 of "The nanoscale molecular morphology of docked exocytic dense-core vesicles in neuroendocrine cells"

description: This dataset is part of a collection of imaging data (https://doi.org/10.25444/nhlbi.c.5405490) from the publication entitled: "The nanoscale molecular morphology of docked exocytic dense-core vesicles in neuroendocrine cells." by Prasai et al. 2021 (https://doi.org/10.1038/s41467-021-24167-9) <br>It contains files for PC12 cells expressing His-tagged Rab3a, Rab27a, Rabphilin3A, Granuphilin-a and Rim2 and tagged with Ni-NTA-gold that are shown in fig. 4a-e.<br><br>HeLa cells were transiently transfected with His-tagged Rab3a, Rab27a, Rabphilin3A, Granuphilin-a and Rim2. Cells were rinsed in intracellular buffer and manually unroofed with 19-gauge needle and syringe using 2% paraformaldehyde. Cells were blocked in 3% BSA/PBS solution for an hour, incubated in a sonicated (5 min) 1:5 solution of 10 nm Ni-NTA-Nanogold in PBS for 1 h. TIRF map was made and samples placed in 2% glutaraldehyde. Samples were prepared for EM images next that included staining with tannic acid and uranyl acetate, dehydration with ethanol and critical point drying. Dried samples were coated with platinum/carbon, replica lifted, transferred to EM grid and 2D TEM images taken at 15,000× magnification (1.2 nm per pixel) using a JEOL 1400 and SerialEM freeware for montaging. 2D TEM was used to survey the gold tagged organelles and tomograms were collected for those cells. Single-axis tilt series (−60° to 60°, 1° increments) were collected at 8,000×. The montages were stitched together, and the tilt series were reconstructed into tomograms using IMOD software.<br><br>
DOI: 10.6084/m9.figshare.17701148.v1
title: EEG Dataset for RSVP and P300 Speller Brain-Computer Interfaces

description: EEG dataset for subject 25
DOI: 10.17632/335c36hm6n
title: Analysis of Coriander, Pumpkin, and Castor Oils

description: FTIR and Raman restuls for Coriander, Pumpkin, and Castor Oils
DOI: 10.17632/37jx7gkz3y
title: Data for: Electoral Rules, Strategic Entry and Polarization

description: Data and do file regarding our laboratory experiment.
DOI: 10.17632/yprnr9w62w
title: Supplemental Table S3: Serum IgG

description: Supplemental Table S3. Characteristics and main results of the eligible studies investigating colostrum heat treatment on serum IgG concentration (g/L) in newborn calves ordered by year of completion.
DOI: 10.17632/t9cgvfd572
title: Dataset for "Social and behavioral determinants of indoor temperatures in air-conditioned homes"

description: This dataset is associated with the manuscript by Wright et al. Social and behavioral determinants of indoor temperatures in air-conditioned homes to be published in 2020 in the journal Building and Environment. As part of the 3HEAT project (NSF award #1520803), this dataset includes indoor temperatures from Phoenix households (PHX_indoor_wide.csv), social survey responses (phx_survey_indoor_manuscript_v2.csv) and outdoor temperatures obtained from the local Phoenix Sky Harbor International Airport National Weather Service weather station (skyharbor.csv). The file 'README_file descriptions.csv' contains brief description of what each file contains and descriptions for each column header. Finally, 'Code for Wright et al Indoor temperatures.Rmd' is an R markdown file that contains the R code necessary to run analyses that appear in the associated manuscript. For a greater description of how these datasets were curated, please refer to the associated manuscript. In brief, indoor temperatures were collected from 46 study participants' homes in the summer of 2016 in Phoenix, Arizona, USA. Study participants were administered a social survey to find out how they use air conditioning, their limitations on air conditioning use, their set and preferred temperatures, and their household resources. The attached social survey data contain no personally identifiable information and the study protocol was reviewed and approved by the Institutional Review Board at Arizona State University (study number 2831). The R script was used to run exploratory analyses on the indoor temperature data and discover associations between the indoor temperatures and the social and behavioral variables from the survey data.
DOI: 10.6084/m9.figshare.22224037.v2
title: Samples for ccdc

description: All samples were assumed to be correct when they were detected by all four basic algorithms described above at a consistent time (±1 year). False samples were identified as samples for which the results of the algorithms were not consistent with the latest CCDC breakpoints. True and false samples numbering 3,850 and 3,189, respectively were used to train and test the RF for identifying CCDC breakpoints In the dataset, the code of “presence” presents the true and false change for the sample. 0 presents the false change, and 1 presents the true change. The code of year presents the year of true change.
DOI: 10.6084/m9.figshare.25040576.v1
title: Supplementary Material for: The combination of SHOX2 and RASSF1A DNA methylation had a diagnostic value in pulmonary nodules and early lung cancer

description: Introduction: The study explored the effects of SHOX2 and RASSF1A DNA methylation in lung cancer (LC). 
Method: Bronchoalveolar lavage fluid (BALF) samples as well as LC and normal adjacent tissues were collected from 72 LC patients and 35 patients with benign pulmonary nodules. Quantitative analysis of SHOX2 and RASSF1A DNA methylation was performed in benign pulmonary nodules and different stages of LC. The diagnostic value of SHOX2 and RASSF1A DNA methylation in LC and benign pulmonary nodules was determined by receiver operating characteristics analysis. Gain/loss-of-function experiments were constructed in LC cells and mouse models of xenograft and pulmonary nodule metastasis. The levels of SHOX2 and transfer-associated genes were tested through qRT-PCR and Western blot. Malignant phenotype of LC cells were assessed by functional experiment. The tumor volume and weight of mice in xenograft models were measured. Pulmonary nodule metastasis was determined through HE staining assay. 5-Azacytidine appeared as a positive control drug.
Result: SHOX2 DNA methylation or RASSF1A DNA methylation had a diagnostic efficiency in pulmonary nodules and early LC, with the two combined had better diagnostic value. SHOX2 expression was upregulated in LC. Similar to 5-Azacytidine, SHOX2 knockdown inhibited LC cell viability, migration and invasion in vitro as well as restrained LC tumorigenesis and pulmonary nodule metastasis in vivo, whereas overexpressed SHOX2 had the opposite effects. 
Conclusion: The combination of SHOX2 and RASSF1A DNA methylation had a diagnostic value in pulmonary nodules and early LC. SHOX2 positively modulated the tumorigenesis and metastasis of LC by regulating DNA methylation processes.
DOI: 10.17632/gspw8w9wt6
title: Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended-spectrum β-lactamase-producing enteroaggregative Escherichia coli infection

description: Metabolomics preprocessed data, the data set is related to figure 2, Extended Data figure S3.