cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28239399.v1
title: Projectile points across the Northern Rocky Mountain front: the Billy Big Spring Site (Blackfeet Reservation, Montana)

description: In the recent past, the Front Ranges of the Northern Rocky Mountains formed a permeable boundary that people repeatedly crossed for trade, subsistence, or warfare, and where people occupying different parts of western North America interacted. In this paper we apply a landscape approach to study pre-contact projectile point morphologies and raw materials, and related changes in the geographic affiliations of peoples using the Billy Big Spring Site, located near the Front Ranges in the Blackfeet Indian Reservation of Montana. This site contains numerous points recovered in chronostratigraphic contexts ranging in age from Late Paleoindian to Late Precontact. The sample includes types and raw materials alternatively typical of the Rockies/Plateau, the Front Ranges, and/or the Plains. Variation in the projectile point record at Billy Big Spring is consistent with the notion that, as observed in the recent past, information networks spanned a wide geographic area that englobed the Plains, the Front Ranges, and the Plateau/Rockies during most of the pre-contact period. Exceptions and changes in the geographic affiliations of people using the site can in turn be related to major environmental and demographic events that occurred in the region.
DOI: 10.5517/ccdc.csd.cc2p0pr5
title: CCDC 2473327: Experimental Crystal Structure Determination

description: Related Article: Fa-Zheng Jin, Lin-Lin Wu, Feng-Lin Xu, Tong-Bu Lu|2026|J.Am.Chem.Soc.|||doi:10.1021/jacs.5c19165
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgvvw
title: CSD 2486939: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.31123532
title: Comparative pathogenicity of a virulent field isolate and an NA S122N genetically modified H3N1 avian influenza virus in chickens

description: Low pathogenic avian influenza viruses (LPAIVs) are typically associated with subclinical or mild disease in poultry. However, recent outbreaks involving atypical LPAIV strains, including H3N1 strains like A/chicken/Belgium/460/2019, have demonstrated severe clinical outcomes despite low intravenous pathogenicity index (IVPI) scores. These findings challenge current classification systems and raise questions about alternative markers of virulence, such as loss of a neuraminidase (NA) glycosylation site linked to plasminogen-binding and haemagglutinin (HA) cleavage. This study compared the pathogenicity of a wild-type H3N1 strain (wtH3N1), isolated from a disease outbreak in Belgium, with a genetically modified, loss-of function variant (mH3N1) carrying a single amino acid substitution (S122N) in NA that blocks plasminogen-dependent cleavage of HA in chickens. Four-week-old pullets and cockerels, and 30-week-old laying hens were inoculated with either wtH3N1 or mH3N1 and clinical signs, egg production, viral replication, <i>post-mortem</i> and tissue pathology were evaluated. Adult hens infected with wtH3N1 showed a complete cessation of egg production, systemic viral replication, and histopathological lesions in the reproductive tract, brain, and kidneys. In contrast, birds infected with mH3N1 displayed only mild, transient reductions in egg production and minimal viral detection. No mortality was observed in any group. All young chickens exhibited subclinical infections. Overall, the S122N mutation significantly attenuated viral virulence and tissue tropism. The study provides functional evidence that position 122 on NA contributes to increased virulence in H3N1 AIV. These findings support the role of molecular markers in risk assessment of non-H5/H7 LPAIVs and highlight the limitations of the current IVPI-based classification system.
DOI: 10.6084/m9.figshare.31123532.v1
title: Comparative pathogenicity of a virulent field isolate and an NA S122N genetically modified H3N1 avian influenza virus in chickens

description: Low pathogenic avian influenza viruses (LPAIVs) are typically associated with subclinical or mild disease in poultry. However, recent outbreaks involving atypical LPAIV strains, including H3N1 strains like A/chicken/Belgium/460/2019, have demonstrated severe clinical outcomes despite low intravenous pathogenicity index (IVPI) scores. These findings challenge current classification systems and raise questions about alternative markers of virulence, such as loss of a neuraminidase (NA) glycosylation site linked to plasminogen-binding and haemagglutinin (HA) cleavage. This study compared the pathogenicity of a wild-type H3N1 strain (wtH3N1), isolated from a disease outbreak in Belgium, with a genetically modified, loss-of function variant (mH3N1) carrying a single amino acid substitution (S122N) in NA that blocks plasminogen-dependent cleavage of HA in chickens. Four-week-old pullets and cockerels, and 30-week-old laying hens were inoculated with either wtH3N1 or mH3N1 and clinical signs, egg production, viral replication, <i>post-mortem</i> and tissue pathology were evaluated. Adult hens infected with wtH3N1 showed a complete cessation of egg production, systemic viral replication, and histopathological lesions in the reproductive tract, brain, and kidneys. In contrast, birds infected with mH3N1 displayed only mild, transient reductions in egg production and minimal viral detection. No mortality was observed in any group. All young chickens exhibited subclinical infections. Overall, the S122N mutation significantly attenuated viral virulence and tissue tropism. The study provides functional evidence that position 122 on NA contributes to increased virulence in H3N1 AIV. These findings support the role of molecular markers in risk assessment of non-H5/H7 LPAIVs and highlight the limitations of the current IVPI-based classification system.
DOI: 10.25505/fiz.icsd.cc2pgvwx
title: CSD 2486940: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgvxy
title: CSD 2486941: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgvyz
title: CSD 2486942: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgvz0
title: CSD 2486943: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgw02
title: CSD 2486944: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgw13
title: CSD 2486945: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgw24
title: CSD 2486946: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2pgw35
title: CSD 2486947: Experimental Crystal Structure Determination

description: Related Article: Md Abdullah Al Muhit, Habiba Binte Kashem, Buddhima K. P. Maldeni Kankanamalage, Gregory Morrison, Natalia B. Shustova, Hans-Conrad zur Loye|2026|Cryst.Growth Des.|||doi:10.1021/acs.cgd.5c01303
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25505/fiz.icsd.cc2q3lhy
title: CSD 2505900: Experimental Crystal Structure Determination

description: Related Article: Lemuel E. Crentsil, Oliver J. Rutt, David G. Free, Murray J. David, Robert D. Smyth, Catherine F. Smura, David A. Keen, Andrew N. Fitch, Joke Hadermann, Simon J. Clarke|2026|J.Am.Chem.Soc.|||doi:10.1021/jacs.5c21494
description: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.29039048
title: Lifestyle risk factors and stroke: findings from the national health and nutrition examination survey (1999–2020) and a Mendelian randomization analysis

description: This study aimed to assess the relationship between lifestyle risk factors and stroke, as well as to quantify causality, using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR). We analyzed data from 28,226 individuals who participated in NHANES between 1999 and 2020. To evaluate the association between lifestyle risk factors and stroke, we used weighted multivariate logistic regression. Genome-wide association study (GWAS) summary data were utilized to conduct bidirectional two-sample MR and multivariate MR analyses. The NHANES observational study found that waist circumference, smoking, and creatinine were consistently and positively associated with stroke in multivariable-adjusted models, with odds ratios (OR) of 1.010 (95% confidence interval [CI], 1.001–1.019, <i>p</i> = 0.046), 1.653 (95% CI, 1.310–2.084, <i>p</i> &lt; 0.001), and 1.400 (95% CI, 1.183–1.657, <i>p</i> &lt; 0.001), respectively. Conversely, engaging in vigorous physical activities was a protective factor against stroke, with an OR of 0.572 (95% CI, 0.342–0.961, <i>p</i> = 0.037). Bidirectional two-sample and multivariate MR analyses revealed a causal link between smoking, waist circumference, and stroke (OR = 1.237, 95% CI, 1.130–1.354; OR = 1.239, 95% CI, 1.149–1.335, respectively). Vigorous activities, especially fitness and recreational activities, serve as a protective factor against stroke. Smoking and increased waist circumference represent consistent lifestyle-related risk factors for stroke.
DOI: 10.6084/m9.figshare.29039048.v1
title: Lifestyle risk factors and stroke: findings from the national health and nutrition examination survey (1999–2020) and a Mendelian randomization analysis

description: This study aimed to assess the relationship between lifestyle risk factors and stroke, as well as to quantify causality, using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR). We analyzed data from 28,226 individuals who participated in NHANES between 1999 and 2020. To evaluate the association between lifestyle risk factors and stroke, we used weighted multivariate logistic regression. Genome-wide association study (GWAS) summary data were utilized to conduct bidirectional two-sample MR and multivariate MR analyses. The NHANES observational study found that waist circumference, smoking, and creatinine were consistently and positively associated with stroke in multivariable-adjusted models, with odds ratios (OR) of 1.010 (95% confidence interval [CI], 1.001–1.019, <i>p</i> = 0.046), 1.653 (95% CI, 1.310–2.084, <i>p</i> &lt; 0.001), and 1.400 (95% CI, 1.183–1.657, <i>p</i> &lt; 0.001), respectively. Conversely, engaging in vigorous physical activities was a protective factor against stroke, with an OR of 0.572 (95% CI, 0.342–0.961, <i>p</i> = 0.037). Bidirectional two-sample and multivariate MR analyses revealed a causal link between smoking, waist circumference, and stroke (OR = 1.237, 95% CI, 1.130–1.354; OR = 1.239, 95% CI, 1.149–1.335, respectively). Vigorous activities, especially fitness and recreational activities, serve as a protective factor against stroke. Smoking and increased waist circumference represent consistent lifestyle-related risk factors for stroke.
DOI: 10.6084/m9.figshare.28919987
title: A simple scoring to predict symptomatic intracranial hemorrhage after stroke thrombolysis: the EGAN score

description: Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis represents a critical and fatal complication observed in acute ischemic stroke (AIS) patients. This study aims to establish a simple scoring model to predict sICH. We retrospectively conducted a cohort study of eligible AIS patients treated with rt-PA at a tertiary comprehensive stroke center from January 2018 to December 2022. Backward stepwise multivariable logistic regression provided the final model. The point score was generated from β-coefficients. The area under the curve (AUC) of the receiver operating characteristics (ROC) and the Hosmer–Lemeshow goodness-of-fit test were used to assess the discrimination and calibration of the model. The conditional probabilities were derived based on the Bayes theorem. Of the included patients, sICH occurred in 26 (3.97%) of the 655. The EGAN score consisted of an early infarct sign (10 points), baseline glucose ≥200 mg/dL (11 points), atrial fibrillation (AF) (13 points), and an NIH Stroke Scale (NIHSS) score ≥10 (12 points). With a cut-off point of 13, the EGAN score demonstrated good discrimination (0.7453 [95% CI: 0.649–0.841]), sensitivity (80.77%), and specificity (58.19%), respectively, for identifying sICH. This easy-to-use scoring model, based on predictors quickly obtained in clinical practices, offers a simple approach to screening for post-thrombolysis sICH and can serve as an alternative option in hospitals with limited resources for thrombolysis therapy.
DOI: 10.6084/m9.figshare.28919987.v1
title: A simple scoring to predict symptomatic intracranial hemorrhage after stroke thrombolysis: the EGAN score

description: Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis represents a critical and fatal complication observed in acute ischemic stroke (AIS) patients. This study aims to establish a simple scoring model to predict sICH. We retrospectively conducted a cohort study of eligible AIS patients treated with rt-PA at a tertiary comprehensive stroke center from January 2018 to December 2022. Backward stepwise multivariable logistic regression provided the final model. The point score was generated from β-coefficients. The area under the curve (AUC) of the receiver operating characteristics (ROC) and the Hosmer–Lemeshow goodness-of-fit test were used to assess the discrimination and calibration of the model. The conditional probabilities were derived based on the Bayes theorem. Of the included patients, sICH occurred in 26 (3.97%) of the 655. The EGAN score consisted of an early infarct sign (10 points), baseline glucose ≥200 mg/dL (11 points), atrial fibrillation (AF) (13 points), and an NIH Stroke Scale (NIHSS) score ≥10 (12 points). With a cut-off point of 13, the EGAN score demonstrated good discrimination (0.7453 [95% CI: 0.649–0.841]), sensitivity (80.77%), and specificity (58.19%), respectively, for identifying sICH. This easy-to-use scoring model, based on predictors quickly obtained in clinical practices, offers a simple approach to screening for post-thrombolysis sICH and can serve as an alternative option in hospitals with limited resources for thrombolysis therapy.
DOI: 10.6084/m9.figshare.29019199
title: Effect of pain-related sodium channels <i>SCN9A</i> and <i>SCN10A</i> polymorphisms in migraine chronification

description: Based on the frequency of attacks, migraine is classified into two subtypes: episodic (EM) and chronic (CM). Migraine progression from EM to CM is supposed to be affected by various factors, which is known as “migraine chronification. However, the pathophysiology of migraine chronification is multifactorial and still not fully understood. Ion channels are hypothesized to play a role in migraine pathophysiology and are essential for generating and suppressing action potentials, which lie under the pain and related symptoms. Two sodium channel genes, <i>SCN9A</i> and <i>SCN10A</i>, have been reported to be associated with various pain sensitivities. Studies have shown that patients with EM and CM are more sensitive to chronic pain and that pain sensitivity may be a risk factor for chronification. Thus, the current study aimed to determine whether pain sensitivity-related <i>SCN9A</i> and <i>SCN10A</i> polymorphisms affect the EM-to-CM transition. For this purpose, genotyping was performed using TaqMan SNP Assay for the (i) <i>SCN9A</i> rs7595255, rs12622743, and rs11898284, (ii) <i>SCN10A</i> rs6795970, rs6801957 SNPs in Turkish EM and CM patients. The results showed that <i>SCN9A</i> and <i>SCN10A</i> polymorphisms did not play a role in the development of chronicity. However, the results indicated that the <i>SCN10A</i> rs6795970 polymorphism was associated with osmophobia (<i>p</i> = 0.036). <i>SCN10A</i> rs6795970 polymorphism may be necessary to predict the EM-to-CM transition and identify therapeutic targets. However, further studies are required to confirm the osmophobia association of the <i>SCN10A</i> rs6795970 polymorphism and to investigate the role of these SNPs in chronification.
DOI: 10.6084/m9.figshare.29019199.v1
title: Effect of pain-related sodium channels <i>SCN9A</i> and <i>SCN10A</i> polymorphisms in migraine chronification

description: Based on the frequency of attacks, migraine is classified into two subtypes: episodic (EM) and chronic (CM). Migraine progression from EM to CM is supposed to be affected by various factors, which is known as “migraine chronification. However, the pathophysiology of migraine chronification is multifactorial and still not fully understood. Ion channels are hypothesized to play a role in migraine pathophysiology and are essential for generating and suppressing action potentials, which lie under the pain and related symptoms. Two sodium channel genes, <i>SCN9A</i> and <i>SCN10A</i>, have been reported to be associated with various pain sensitivities. Studies have shown that patients with EM and CM are more sensitive to chronic pain and that pain sensitivity may be a risk factor for chronification. Thus, the current study aimed to determine whether pain sensitivity-related <i>SCN9A</i> and <i>SCN10A</i> polymorphisms affect the EM-to-CM transition. For this purpose, genotyping was performed using TaqMan SNP Assay for the (i) <i>SCN9A</i> rs7595255, rs12622743, and rs11898284, (ii) <i>SCN10A</i> rs6795970, rs6801957 SNPs in Turkish EM and CM patients. The results showed that <i>SCN9A</i> and <i>SCN10A</i> polymorphisms did not play a role in the development of chronicity. However, the results indicated that the <i>SCN10A</i> rs6795970 polymorphism was associated with osmophobia (<i>p</i> = 0.036). <i>SCN10A</i> rs6795970 polymorphism may be necessary to predict the EM-to-CM transition and identify therapeutic targets. However, further studies are required to confirm the osmophobia association of the <i>SCN10A</i> rs6795970 polymorphism and to investigate the role of these SNPs in chronification.