cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18787257
title: From cancer to heart fibrosis - GLIPR1 highlights a subset of myofibroblasts responsive to mesenchymal stem cell therapy after myocardial infarction

description: Abstract



Despite recent advances in pre-clinical research on cardiac remodeling following myocardial infarction (MI), the precise molecular pathways remain poorly understood and effective therapies for heart failure are still delayed in development. Aged animal models may more accurately reflect the clinical scenario, as aging alters the cellular identities and impedes cardiac repair. In this manuscript, we investigated the expression profile of mouse cardiac fibroblasts following myocardial infarction, using both young and aged animals to enhance the translational significance. The initial studies aimed to identify fibroblast changes common to both young and old animals. Additionally, a group of young animals that underwent mesenchymal stem cells (MSC) therapy after MI surgery was included to help identify the molecular changes amenable to therapeutic modulation. The analysis uncovered Glioma- Pathogenesis Related Protein 1 (GLIPR1) activation during the post-MI maturation phase in a subset of myofibroblasts, localized to the infarct zone in young subjects and widespread throughout the ventricle in aged animals. Further investigations indicated that the inflammatory environment post-MI induced the upregulation of GLIPR1, which in turn promoted increased TIMP3 expression. These findings provide valuable insights for future research aimed at exploring the therapeutic potential of targeting GLIPR1 to reduce cardiac fibrosis post-MI.


Keywords: Aged mice; Cardiac fibroblast; GLIPR1; MSC therapy; Myocardial infarction; RNA-sequencing.
DOI: 10.5281/zenodo.18787256
title: From cancer to heart fibrosis - GLIPR1 highlights a subset of myofibroblasts responsive to mesenchymal stem cell therapy after myocardial infarction

description: Abstract



Despite recent advances in pre-clinical research on cardiac remodeling following myocardial infarction (MI), the precise molecular pathways remain poorly understood and effective therapies for heart failure are still delayed in development. Aged animal models may more accurately reflect the clinical scenario, as aging alters the cellular identities and impedes cardiac repair. In this manuscript, we investigated the expression profile of mouse cardiac fibroblasts following myocardial infarction, using both young and aged animals to enhance the translational significance. The initial studies aimed to identify fibroblast changes common to both young and old animals. Additionally, a group of young animals that underwent mesenchymal stem cells (MSC) therapy after MI surgery was included to help identify the molecular changes amenable to therapeutic modulation. The analysis uncovered Glioma- Pathogenesis Related Protein 1 (GLIPR1) activation during the post-MI maturation phase in a subset of myofibroblasts, localized to the infarct zone in young subjects and widespread throughout the ventricle in aged animals. Further investigations indicated that the inflammatory environment post-MI induced the upregulation of GLIPR1, which in turn promoted increased TIMP3 expression. These findings provide valuable insights for future research aimed at exploring the therapeutic potential of targeting GLIPR1 to reduce cardiac fibrosis post-MI.


Keywords: Aged mice; Cardiac fibroblast; GLIPR1; MSC therapy; Myocardial infarction; RNA-sequencing.
DOI: 10.13018/bmr34326
title: Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1/2 of Drosophila helicase MLE
DOI: 10.13018/bmr34328
title: Dodecamer DNA containing the synthetic base pair P-Z
DOI: 10.13018/bmr34329
title: NMR structure of the third TPR domain of the human SPAG1 protein
DOI: 10.13018/bmr34330
title: Solution structure of TRIM28 RING domain
DOI: 10.13018/bmr34331
title: Human telomeric G-quadruplex with 8-oxo-G substitution in the central G-quartet
DOI: 10.15468/dl.68jjhr
title: Occurrence Download

description: A dataset containing 185 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is AquaInvaders"
 ]
}

 The dataset includes 185 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003575-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr34332
title: Human telomeric G-quadruplex with 8-oxo-G substitution in the outer G-quartet
DOI: 10.13018/bmr34333
title: Solution structure of the water-soluble LU-domain of human Lypd6 protein
DOI: 10.13018/bmr34334
title: NMR solution structure of the HVO_2922 protein from Haloferax volcanii
DOI: 10.13018/bmr34335
title: H-Vc7.2, H-superfamily conotoxin
DOI: 10.13018/bmr34336
title: Structural and functional insights into the condensin ATPase cycle
DOI: 10.13018/bmr34338
title: Solution NMR structure of outer membrane protein AlkL
DOI: 10.13018/bmr34339
title: Structure determination of N-terminal fragment of UL49.5 protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics
DOI: 10.15468/dl.q452c5
title: Occurrence Download

description: A dataset containing 597 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lutra lutra",
 "Country is Germany",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year 2022-2025"
 ]
}

 The dataset includes 597 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003572-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr34340
title: P31-43
DOI: 10.15468/dl.jrrusc
title: Occurrence Download

description: A dataset containing 11026 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lacerta agilis",
 "Country is Germany",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year 2005-2020"
 ]
}

 The dataset includes 11026 records from 93 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003574-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr34341
title: Structural investigation of the TasA anchoring protein TapA from Bacillus subtilis
DOI: 10.13018/bmr34342
title: P31-43.
DOI: 10.13018/bmr34343
title: P31-43.
DOI: 10.13018/bmr34344
title: NMR structure of BB_P28, Borrelia burgdorferi outer surface lipoprotein
DOI: 10.13018/bmr34345
title: NMR Structure of Big-defensin 1 [44-93] from oyster Crassostrea gigas
DOI: 10.13018/bmr34346
title: NMR Structure of Big-defensin 1 from oyster Crassostrea gigas
DOI: 10.13018/bmr34347
title: Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration
DOI: 10.13018/bmr34348
title: [1-40]Gga-AvBD11
DOI: 10.13018/bmr34349
title: [41-82]Gga-AvBD11
DOI: 10.13018/bmr34350
title: Gga-AvBD11 (Avian beta-defensin 11 from Gallus gallus)
DOI: 10.13018/bmr34351
title: Solution NMR ensemble for human ubiquitin at 298K compiled using the CoMAND method
DOI: 10.13018/bmr34352
title: Solution NMR ensemble for a chimeric KH-S1 domain construct of exosomal polynucleotide phosphrylase at 298K compiled using the CoMAND method
DOI: 10.13018/bmr34353
title: TINA-conjugated antiparallel DNA triplex
DOI: 10.13018/bmr34354
title: Truncated Evasin-3 (tEv3 17-56)
DOI: 10.13018/bmr34355
title: Solution Structure of the Zn-loaded form of a Metallothionein from Helix Pomatia
DOI: 10.13018/bmr34356
title: Solution Structure of the Cd-loaded form of a Metallothionein from Helix Pomatia
DOI: 10.13018/bmr34357
title: Structure investigations of Protegrin-4 by High resolution NMR spectroscopy
DOI: 10.13018/bmr34358
title: NMR solution structure of LSR2 binding domain.
DOI: 10.5281/zenodo.18787310
title: Thermographic data for manuscript Mus.4189-E-6,8 (SLUB)

description: This data set contains thermographic images for the visualisation of watermarks. An IRCAM Equus 327k with Watermark Imager software (Fraunhofer) version 8.416 (R2016b) was used.
DOI: 10.5281/zenodo.18787311
title: Thermographic data for manuscript Mus.4189-E-6,8 (SLUB)

description: This data set contains thermographic images for the visualisation of watermarks. An IRCAM Equus 327k with Watermark Imager software (Fraunhofer) version 8.416 (R2016b) was used.
DOI: 10.13018/bmr34359
title: NMR solution structure of LSR2-T112D binding domain.
DOI: 10.13018/bmr34360
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Nisin Ring B (Lan8,11) analogue
DOI: 10.13018/bmr34361
title: NMR structure of BB_A03, Borrelia burgdorferi outer surface lipoprotein
DOI: 10.13018/bmr34362
title: tSH2 domain of transcription elongation factor Spt6 complexed with tyrosine phosphorylated CTD
DOI: 10.13018/bmr34363
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Mutacin I Ring B, major conformer
DOI: 10.13018/bmr34365
title: Solid-state NMR structure of outer membrane protein AlkL in DMPC lipid bilayers
DOI: 10.13018/bmr34366
title: NMR structure of peptide 7, characterized by a cis-4-amino-Pro residue, with a significant lower MIC on E. coli
DOI: 10.13018/bmr34367
title: NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa.
DOI: 10.5281/zenodo.18787297
title: Thermal conductivity of monolayer CrSBr

description: ==unit_cell_relaxation==VASP input and output files of the structural optimization of the unit cell (POTCARs not included as their use is subject to ownership of a VASP license)

==BTE_solution==AlmaBTE input and output files for calculation of the thermal conductivity
DOI: 10.13018/bmr34369
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Mutacin I Ring B, minor conformer
DOI: 10.5281/zenodo.18787296
title: Thermal conductivity of monolayer CrSBr

description: ==unit_cell_relaxation==VASP input and output files of the structural optimization of the unit cell (POTCARs not included as their use is subject to ownership of a VASP license)

==BTE_solution==AlmaBTE input and output files for calculation of the thermal conductivity
DOI: 10.13018/bmr34370
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Nisin Ring B
DOI: 10.13018/bmr34371
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Mutacin I Ring A truncated analogue
DOI: 10.13018/bmr34372
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Mutacin I Ring A
DOI: 10.13018/bmr34373
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Mutacin I Ring A (Ser2, Ala5, Ala8) analogue
DOI: 10.13018/bmr34374
title: Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - nisin ring A
DOI: 10.13018/bmr34376
title: The N-terminal domain of rhomboid protease YqgP
DOI: 10.13018/bmr34378
title: Structure of kiteplatinated dsDNA
DOI: 10.13018/bmr34379
title: Solution structure of sortase A from S. aureus in complex with 2-(aminomethyl)-3-hydroxy-4H-pyran-4-one based prodrug
DOI: 10.13018/bmr34380
title: Structure of peptide P7, which binds Cdc42 and inhibits effector interactions.
DOI: 10.13018/bmr34381
title: NMR structure of Chromogranin A (F39-D63)
DOI: 10.13018/bmr34383
title: Solution structure of birch pollen allergen Bet v 1a
DOI: 10.13018/bmr34384
title: C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1
DOI: 10.13018/bmr34385
title: Solution Structure of ribosome-binding factor A (RbfA) under physiological conditions
DOI: 10.13018/bmr34386
title: SC14 G-hairpin
DOI: 10.13018/bmr34387
title: The solution NMR structure of cis-dicarba-brevinin-1BYa in 33% trifluoroethanol
DOI: 10.13018/bmr34388
title: The solution NMR structure of cis-dicarba-brevinin-1BYa in sodium dodecyl sulphate micelles
DOI: 10.13018/bmr34389
title: A quadruplex hybrid structure with lpp loop orientation and 3 syn residues
DOI: 10.13018/bmr34390
title: A quadruplex hybrid structure with lpp loop orientation and 5 syn residues
DOI: 10.13018/bmr34391
title: 3D NMR solution structure of ligand peptide (Ac)EVNPPVP of Pro-Pro endopeptidase-1
DOI: 10.5519/qd.1x7l7tj9
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (6151799 records)
DOI: 10.13018/bmr34392
title: NMR structure of cytotoxin 3 from Naja kaouthia in solution, major form
DOI: 10.13018/bmr34393
title: Bordetella pertussis adenylate cyclase toxin transmembrane segment 411-490 in DPC micelles
DOI: 10.13018/bmr34394
title: Solution structure and 1H, 13C and 15N chemical shift assignments for NECAP1 PHear domain
DOI: 10.13018/bmr34395
title: Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of NECAP1 PHear domain with phosphorylated AP2 mu2 148-163
DOI: 10.13018/bmr34396
title: Structure of pore-forming amyloid-beta tetramers
DOI: 10.13018/bmr34397
title: Imidazole Polyamide-DNA complex NMR structure (5'-CGATGTACATCG-3')
DOI: 10.13018/bmr34398
title: Concerted dynamics of metallo-base pairs in an A/B-form helical transition (apo species)
DOI: 10.13018/bmr34399
title: Extremely stable monomeric variant of human cystatin C with single amino acid substitution
DOI: 10.13018/bmr34400
title: RW16 peptide
DOI: 10.13018/bmr34401
title: Solution NMR structure of the peptide 3967 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
DOI: 10.13018/bmr34402
title: Solution NMR structure of the peptide 536_2 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
DOI: 10.13018/bmr34403
title: 2'-F-riboguanosine modified G-quadruplex with V-loop
DOI: 10.13018/bmr34404
title: NMR structure of pleurocidin KR in SDS micelles
DOI: 10.13018/bmr34405
title: NMR structure of pleurocidin VA in SDS micelles
DOI: 10.13018/bmr34406
title: Solution NMR structure of the peptide 12530 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
DOI: 10.13018/bmr34407
title: Solution structure of the fourth WW domain of WWP2 with GB1-tag
DOI: 10.13018/bmr34408
title: STRUCTURE OF [ASP58]-IGF-I ANALOGUE
DOI: 10.13018/bmr34409
title: Structure of HIV-1 CAcSP1NC mutant(W41A,M42A) interacting with maturation inhibitor EP39
DOI: 10.13018/bmr34410
title: Winter flounder 1a-1 in SDS micelles
DOI: 10.13018/bmr34411
title: Winter flounder 1a in SDS micelles
DOI: 10.13018/bmr34412
title: Winter flounder 3 in SDS micelles
DOI: 10.15468/dl.rpqs42
title: Occurrence Download

description: A dataset containing 72465 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Lotus pedunculatus",
 "Year is less than or equal to 2000",
 "Year is greater than or equal to 1970",
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is one of (MANAGED, INTRODUCED)"
 ]
 }
 },
 "EstablishmentMeans is null"
 ]
 },
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 1000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 72465 records from 248 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003536-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.aypbpc
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Allamanda cathartica",
 "Country is Grenada",
 "HasCoordinate is true"
 ]
}

 The dataset includes 10 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078540-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.97ffep
title: Occurrence Download

description: A dataset containing 661895 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Amazilia tzacatl)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 661895 records from 149 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078514-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25954/3xj8-0k86
title: Lipoceramic Technologies: a Solution to Low and Variable Bioavailability of Poorly Soluble Anti-Inflammatory Drugs [IWEMC-325]
DOI: 10.15468/dl.s6sm9x
title: Occurrence Download

description: A dataset containing 13190 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gracillaria syringella",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 13190 records from 173 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078541-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2kg8nw
title: Occurrence Download

description: A dataset containing 2159 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aedes vigilax"
 ]
}

 The dataset includes 2159 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086327-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fcfqaf
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Otocinclus batmani)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence, Human Observation, Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1991",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 9 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086328-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.522h62
title: Occurrence Download

description: A dataset containing 3169 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rubus armeniacus",
 "Country is Sweden",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3169 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0086329-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15156/bio/sh1413385.10fu
title: SH1413385.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1413387.10fu
title: SH1413387.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1413392.10fu
title: SH1413392.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1413398.10fu
title: SH1413398.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.