cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19095443
title: Supplementary Material for: Anti-<b><i>Ascaris</i></b> IgE as a Risk Factor for Asthma Symptoms among 5-Year-Old Children in Rural Bangladesh with Even Decreased <b><i>Ascaris</i></b> Infection Prevalence

description: <b><i>Background:</i></b> Epidemiological studies have indicated that anti-<i>Ascaris</i> IgE enhances asthma and allergies under specific conditions although the association between them is still controversial. The association of anti-<i>Ascaris</i> IgE with increased asthma symptoms among children from a general population with a mild to moderate <i>Ascaris</i> infection prevalence was investigated. <b><i>Methods:</i></b> A total of 126 children aged 5 years with wheezing during the previous year and 110 children who did not have wheezing were selected randomly from the rural service area of the International Centre for Diarrhoeal Disease Research, Bangladesh. Serum levels of total, anti-<i>Ascaris</i>, anti-<i>Dermatophagoides pteronyssinus</i>, and anti-cockroach IgEs were tested, and their risks for wheezing were analyzed. The wheezing children were then classified by hierarchical cluster analysis to investigate the contribution of anti-<i>Ascaris</i> IgE to wheezing. <b><i>Results:</i></b> The anti-<i>Ascaris</i> IgE levels in wheezing and never-wheezing children were 1.07 and 0.65 U<sub>A</sub>/mL, and it contributed to 11% of wheezing in children. Anti-<i>Ascaris</i> IgE was significantly associated with wheezing (odds ratio [OR] per log<sub>e</sub> increment: 1.37 [95% CI: 1.01–1.87], <i>p</i> = 0.046). The ORs, which were adjusted for sex, parental asthma, pneumonia history, helminth infections, <i>Haemophilus influenzae</i> type B combination vaccination, antibiotic use during infancy, and total and specific IgE levels, increased even when only children with more specific symptoms of asthma were included in the analysis. Namely, the ORs for wheezing with sleep disturbance, four or more attacks, and wheezing with speech difficulties during the previous 1 year were OR = 1.44/log<sub>e</sub> increment [95% CI: 1.01–2.07], OR = 1.90/log<sub>e</sub> increment [95% CI: 1.11–3.25], and OR = 1.78/log<sub>e</sub> increment [95% CI: 1.01–3.14], respectively. <b><i>Conclusions:</i></b> The anti-<i>Ascaris</i> IgE levels in wheezing and never-wheezing children in the current study significantly decreased concurrently with <i>Ascaris</i> infection prevalence compared with their corresponding values in 2001. The contribution of anti-<i>Ascaris</i> IgE to wheezing also dropped from 26% in 2001 to 11% in the current study. Despite significant decreases in the levels and the seroprevalence and its contribution to wheezing, anti-<i>Ascaris</i> IgE remained significantly associated with increased risk of wheezing. Anti-<i>Ascaris</i> IgE significantly increased the risk of wheezing in a general population with a mild to moderate <i>Ascaris</i> infection prevalence, suggesting robustness as a risk factor and a possible dose-response relationship.
DOI: 10.6084/m9.figshare.19095443.v2
title: Supplementary Material for: Anti-<b><i>Ascaris</i></b> IgE as a Risk Factor for Asthma Symptoms among 5-Year-Old Children in Rural Bangladesh with Even Decreased <b><i>Ascaris</i></b> Infection Prevalence

description: <b><i>Background:</i></b> Epidemiological studies have indicated that anti-<i>Ascaris</i> IgE enhances asthma and allergies under specific conditions although the association between them is still controversial. The association of anti-<i>Ascaris</i> IgE with increased asthma symptoms among children from a general population with a mild to moderate <i>Ascaris</i> infection prevalence was investigated. <b><i>Methods:</i></b> A total of 126 children aged 5 years with wheezing during the previous year and 110 children who did not have wheezing were selected randomly from the rural service area of the International Centre for Diarrhoeal Disease Research, Bangladesh. Serum levels of total, anti-<i>Ascaris</i>, anti-<i>Dermatophagoides pteronyssinus</i>, and anti-cockroach IgEs were tested, and their risks for wheezing were analyzed. The wheezing children were then classified by hierarchical cluster analysis to investigate the contribution of anti-<i>Ascaris</i> IgE to wheezing. <b><i>Results:</i></b> The anti-<i>Ascaris</i> IgE levels in wheezing and never-wheezing children were 1.07 and 0.65 U<sub>A</sub>/mL, and it contributed to 11% of wheezing in children. Anti-<i>Ascaris</i> IgE was significantly associated with wheezing (odds ratio [OR] per log<sub>e</sub> increment: 1.37 [95% CI: 1.01–1.87], <i>p</i> = 0.046). The ORs, which were adjusted for sex, parental asthma, pneumonia history, helminth infections, <i>Haemophilus influenzae</i> type B combination vaccination, antibiotic use during infancy, and total and specific IgE levels, increased even when only children with more specific symptoms of asthma were included in the analysis. Namely, the ORs for wheezing with sleep disturbance, four or more attacks, and wheezing with speech difficulties during the previous 1 year were OR = 1.44/log<sub>e</sub> increment [95% CI: 1.01–2.07], OR = 1.90/log<sub>e</sub> increment [95% CI: 1.11–3.25], and OR = 1.78/log<sub>e</sub> increment [95% CI: 1.01–3.14], respectively. <b><i>Conclusions:</i></b> The anti-<i>Ascaris</i> IgE levels in wheezing and never-wheezing children in the current study significantly decreased concurrently with <i>Ascaris</i> infection prevalence compared with their corresponding values in 2001. The contribution of anti-<i>Ascaris</i> IgE to wheezing also dropped from 26% in 2001 to 11% in the current study. Despite significant decreases in the levels and the seroprevalence and its contribution to wheezing, anti-<i>Ascaris</i> IgE remained significantly associated with increased risk of wheezing. Anti-<i>Ascaris</i> IgE significantly increased the risk of wheezing in a general population with a mild to moderate <i>Ascaris</i> infection prevalence, suggesting robustness as a risk factor and a possible dose-response relationship.
DOI: 10.5281/zenodo.7870369
title: A study on biomedical researchers' perspectives on public engagement in Southeast Asia

description: Qualitative data on researcher's perceptions of public and community engagement in South and Southeast Asia
DOI: 10.5281/zenodo.7870368
title: A study on biomedical researchers' perspectives on public engagement in Southeast Asia

description: Qualitative data on researcher's perceptions of public and community engagement in South and Southeast Asia
DOI: 10.5517/ccdc.csd.cc2f8rl2
title: CCDC 2242744: Experimental Crystal Structure Determination

description: Related Article: M. Carla Aragoni, Massimiliano Arca, Francesco Demartin, Alessandra Garau, Francesco Isaia, Vito Lippolis, Tiziana Pivetta|2023|New J.Chem.|47|8122|doi:10.1039/D3NJ00855J
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dk0kk
title: CCDC 2220888: Experimental Crystal Structure Determination

description: Related Article: Fang-Xue Xu, Ying-Lian Li, Xiao-Qin Wei, Dong Shao, Le Shi, Hai-Yan Wei, Xin-Yi Wang|2023|Dalton Trans.|52|5575|doi:10.1039/D3DT00610G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fkhdx
title: CCDC 2251139: Experimental Crystal Structure Determination

description: Related Article: Yuefeng Duan, Yuhang Huang, Chongqing Wang, Qian Wang, Kai Ge, Zhiyong Lu, Huijie Wang, Jingui Duan, Junfeng Bai, Wanqin Jin|2023|Chemical Science|14|4605|doi:10.1039/D3SC00877K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dk0mm
title: CCDC 2220890: Experimental Crystal Structure Determination

description: Related Article: Fang-Xue Xu, Ying-Lian Li, Xiao-Qin Wei, Dong Shao, Le Shi, Hai-Yan Wei, Xin-Yi Wang|2023|Dalton Trans.|52|5575|doi:10.1039/D3DT00610G
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dm3bh
title: CCDC 2222896: Experimental Crystal Structure Determination

description: Related Article: Jinni Zhao, Xilong Leng, Jiazhao Lin, Xiaoping Yang, Xiaoli Lv, Xianfeng Huang, Zhi Yang, Desmond Schipper|2023|Chem.Commun.|59|5435|doi:10.1039/D2CC06504E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f036s
title: CCDC 2234424: Experimental Crystal Structure Determination

description: Related Article: K. Randall McClain, Hyunchul Kwon, Khetpakorn Chakarawet, Rizwan Nabi, Jon G. C. Kragskow, Nicholas F. Chilton, R. David Britt, Jeffrey R. Long, Benjamin G. Harvey|2023|J.Am.Chem.Soc.|145|8996|doi:10.1021/jacs.3c00182
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fm84h
title: CCDC 2252836: Experimental Crystal Structure Determination

description: Related Article: Martin Nieger, Ralph Detsch and Edgar Niecke|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fmqf7
title: CCDC 2253279: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold and Joseph O'Connor|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fmqg8
title: CCDC 2253280: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc29jh3g
title: CCDC 2131005: Experimental Crystal Structure Determination

description: Related Article: Moon Kedia, K. R. Soumya, Upasana Phukon, Isha Mishra, Reema L. Borkar, Palanichamy Vengadeshwaran, Mamina Bhol, Malaichamy Sathiyendiran|2023|CrystEngComm|25|2518|doi:10.1039/D3CE00264K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fmqh9
title: CCDC 2253281: Experimental Crystal Structure Determination

description: Related Article: Arnold L. Rheingold|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d8rgx
title: CCDC 2212949: Experimental Crystal Structure Determination

description: Related Article: Moon Kedia, K. R. Soumya, Upasana Phukon, Isha Mishra, Reema L. Borkar, Palanichamy Vengadeshwaran, Mamina Bhol, Malaichamy Sathiyendiran|2023|CrystEngComm|25|2518|doi:10.1039/D3CE00264K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2d25nb
title: CCDC 2206631: Experimental Crystal Structure Determination

description: Related Article: K. Roszak, A. Katrusiak|2023|IUCrJ|10|341|doi:10.1107/S2052252523002452
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15129/197577c8-b28e-43b4-9ab4-badd48c084f7
title: Data for: "Alkali Metal Dihydropyridines in Transfer Hydrogenation Catalysis of Imines: Amide Basicity versus Hydride Surrogacy"

description: The dataset contains the following 3 files: 1. NMR Data (zip file) 2. X-Ray raw data (cif file) 3. Theoretical data (zip file) The dataset relates to research reported in the manuscript in the title, carried out as part of the Leverhulme funded project. Please note that the NMR data requires a specialist program such as Topspin or Mestrelab, and the X-Ray data (.cif) requires a program such as Olex or Mercury to view. The theoretical data was generated by ORCA is in plain text however can be visualized with the program Avogadro.
DOI: 10.6084/m9.figshare.22758692.v2
title: An Open-Source Carbon Footprint Calculator of the UK Craft Brewing Value Chain.xlsx

description: An open-source carbon footprint calculator of the UK craft brewing value chain
DOI: 10.6084/m9.figshare.22758692.v3
title: An Open-Source Carbon Footprint Calculator of the UK Craft Brewing Value Chain.xlsx

description: An open-source carbon footprint calculator of the UK craft brewing value chain
DOI: 10.25678/0008da
title: Data for: Multilateral development banks investment behaviour in water and sanitation: findings and lessons from 60 years of investment projects in Africa and Asia

description: Multilateral development banks (MDBs) play a pivotal role in financing water and sanitation infrastructure projects and thus have a major impact on the development of basic services. Although information about the MDBs' investments is publicly available, it is dispersed and not easily comparable. A comprehensive compilation of MDBs' water and sanitation investments has long been lacking. To address this gap, we assess water and sanitation financing by the three MDBs most relevant to Africa and Asia between 1960 and 2020: the World Bank, the African Development Bank, and the Asian Development Bank. We compile a new dataset by drawing on 3,639 water and sanitation projects and assess territorial trends, technology choices, distribution of financial burdens, and reforms to institutional arrangements. We find that MDBs' investments align with changing patterns of urbanization and increasingly finance sanitation infrastructures including non-sewered technologies. However, our results also suggest that institutional reforms have addressed utility efficiency through investment in equipment and skills rather than through increased commercialization and private sector participation. The leverage effect of MDB investment on private financing is negligible, whereas co-financing from local governments dominates.
DOI: 10.6084/m9.figshare.21358539.v1
title: data.xlsx

description: Differences in methanogenic pathways and methanogenic communities in paddy soils under three typical cropping modes <br>
DOI: 10.5281/zenodo.7366800
title: Brachycephalus pitanga exposed to Bd-GPL and Bd-Brazil

description: Second release of data associated with 'Host immune responses to enzootic and invasive pathogen lineages vary in magnitude, timing, and efficacy' for Zenodo archiving.
DOI: 10.6073/pasta/087795f6fac0f174397536ab27d50db6
title: Long-term climate indices (SPEI and scPDSI) derived from monthly meteorology data collected at USHCN stations in the northern Chihuahuan Desert of the United States, 1911-2021

description: Drought indices — Standardized Precipitation Evapotranspiration Index (SPEI) and the self-calibrating Palmer Drought Severity Index (scPDSI) —where derived from 9 United States Historical Climate Network (USHCN) stations on the Chihuahuan Desert in North America for this dataset. USHCN is a subset of the NOAA Cooperative Observer Program (COOP) Network, which consists of selected sites based on spatial coverages and completeness of data. Monthly precipitation depths, minimum, maximum and mean temperature were pulled from the dataset. These drought indices were derived using the SPEI package and scPDSI packages in R. Potential evapotranspiration was also calculated in R using the Thornthwaite method. All 9 sites are within the bounds of the Chihuahuan Desert in the state of New Mexico, with a single site (EL PASO) in the state of Texas.
DOI: 10.6084/m9.figshare.21173809
title: Supplementary Material for: Estradiol Replacement as a Potential Enhancer of Working Memory and Neuroplasticity in Hypogonadal Trans Women

description: Introduction: The cognitive effects of cross-sex hormone therapy (CSHT) are not well understood. In cisgender individuals, sex hormone therapy can impact neurotransmitter levels and structural anatomy. Similarly, in gender-diverse persons, CSHT has been associated with neural adaptations, such as growth in brain structures resembling those observed in cisgender individuals of the same sex. Hormone-related changes in learning and memory, as seen in menopause, are associated with physiological hypogonadism or a decline in hormones, such as estradiol. The present study examined the effect of estradiol administration in humans on glutamate concentration in brain regions involved in semantic and working memory (i.e., the dorsolateral prefrontal cortex (DLPFC), the posterior hippocampus, and the pregenual anterior cingulate cortex (ACC)) and its relationship with memory. Methods: Eighteen trans women (male biological sex assigned at birth) ceased CSHT for 30-days for a washout phase (t1) upon study enrollment to reach a hypogonadal state. Working and semantic memory, cognition, hormonal assays, and brain imaging were assessed. Participants resumed CSHT for 60-days for a replacement phase (t2), after which the same evaluations from t1 were repeated. Results: Estradiol increased among trans women after 60-days of resumed CSHT with significant improvements in semantic memory compared to the hypogonadal phase. Working memory recall was significantly and positively correlated to glutamate in the DLPFC during the reinstatement phase, although the relationship was not moderated by levels of estradiol. Discussion: These results may have clinical implications for the therapeutic effects of estradiol replacement serving as a protective factor against cognitive decline and impairment for trans women post-gonadectomy.
DOI: 10.6084/m9.figshare.21681455
title: Supplementary Material for: Cancer associated fibroblasts induce proliferation and therapeutic resistance to everolimus in neuroendocrine tumors through STAT3 activation

description: Introduction Cancer-associated fibroblasts (CAF) have been identified as relevant contributors to cancer progression and drug resistance in many tumors. Although neuroendo-crine tumors (NET) are often associated with a strong stromal reaction, no study has addressed whether CAF are involved in progression and therapeutic resistance in NET. The aim of this study was to characterize the role of CAF in NET. Methods We established primary CAF cultures derived from NET liver metastases to study the effect on NET cell lines NT-3 and BON. Immunohistochemistry was performed on tissue sections of primary and metastatic NET tissue. Results Immunohistochemistry identified CAF dispersed in between tumor cells and within fibrotic bands separating tumor cell clusters in NET. Stimulating NET cells with CAF decreased expression of SSTR2 and chromogranin A and induced expression of CXCR4. CAF induced a 2.3-fold increase in proliferation and completely reversed the response to everolimus in NT-3 cells. We identified STAT3 as the main signal-ing pathway induced by CAF. STAT3 targeting by small interfering RNA (siRNA) knockdown and inhibitors prevented CAF induced proliferation and restored evero-limus responsiveness. STAT3 activation in NET tissue was associated with de-creased chromogranin A expression, increased Ki-67 index and decreased 5-year overall and progression free survival. CAF directly influence proliferation and thera-peutic response in NET cells. Conclusion Identifying STAT3 as the contributing pathway of this so far neglected tumor-stroma interaction has the potential to become a new therapeutic target to halt tumor growth and to restore therapeutic responsiveness in NET.
DOI: 10.6084/m9.figshare.4292891
title: Reduced chemical kinetic models for butanol isomers

description: This dataset contains reduced chemical kinetic models for the isomers of butanol, generated using the directed relation graph with error propagation (DRGEP) and DRGEP and sensitivity analysis (DRGEPSA). Two separate detailed models for the butanol isomers were reduced: the Sarathy and Merchant models (see README for associated references).<br>The reduction_output archive contains the metadata for the reduction, and the necessary thermodynamic and transport data files are included for each set of model files.
DOI: 10.5517/cc3xjvc
title: CCDC 116803: Experimental Crystal Structure Determination

description: Related Article: M.Nieger, E.Niecke, A.Loew|1999|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.