cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/0m1-lk8-dce
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/f7j-022-ekg
title: Anthemis arvensis subsp. cyllenea (Halácsy) R. Fern.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/4xp-pvp-2fm
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wkr-vy8-tvw
title: Parentucellia latifolia (L.) Caruel

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/s7b-l34-53n
title: Anthemis arvensis subsp. cyllenea (Halácsy) R. Fern.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/2rr-tav-wq5
title: Guatteria punctata (Aubl.) R. A. Howard

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bfx-m2y-bs9
title: Parentucellia latifolia (L.) Caruel

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bxk-3yt-fdw
title: Anthemis arvensis subsp. cyllenea (Halácsy) R. Fern.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/xys-4k5-3mv
title: Guatteria australis A. St.-Hil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hvb-3f8-jem
title: Guatteria australis A. St.-Hil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/9zq-012-yg1
title: Guatteria eriopoda DC. ex Dunal

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/z79-hyb-m8a
title: Anthemis arvensis subsp. cyllenea (Halácsy) R. Fern.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/m9e-khz-6wy
title: Anthemis arvensis subsp. cyllenea (Halácsy) R. Fern.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wl9-a3h-q5w
title: Guatteria punctata (Aubl.) R. A. Howard

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/8m5-kde-zpp
title: Anthemis arvensis subsp. cyllenea (Halácsy) R. Fern.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hz3-7tl-vqg
title: Guatteria eriopoda DC. ex Dunal

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/7t8-2st-185
title: Parentucellia latifolia (L.) Caruel

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/nfb-4ql-rm5
title: Guatteria punctata (Aubl.) R. A. Howard

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/jvb-523-nfv
title: Parentucellia latifolia (L.) Caruel

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/h80-5g9-wy3
title: Axonopus singularis (Swallen) Alicia López & Morrone

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/m1x-t2s-lr1
title: Cota altissima (L.) J. Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hxq-z6e-790
title: Cota altissima (L.) J. Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ph9-lg5-4kp
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/f4e-03x-3yy
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wd9-v1n-v36
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ksc-lxd-5hv
title: Guatteria punctata (Aubl.) R. A. Howard

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/y9j-awd-2n0
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.94gsrs
title: Occurrence Download

description: A dataset containing 1722 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Eucidaris thouarsii (L.Agassiz & Desor, 1846)"
 ]
}

 The dataset includes 1722 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113336-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/wq7-qa8-72n
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/17m-zgb-n7a
title: Anthemis arvensis subsp. arvensis

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hwq-m9r-wj5
title: Parentucellia latifolia (L.) Caruel

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/7n9-fv6-w10
title: Anthemis arvensis subsp. arvensis

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/84e-n3p-ng5
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/pmy-6sz-d5t
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/42e-gl1-87s
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/tw8-n8c-kc7
title: Anthemis arvensis subsp. arvensis

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/3x6-5tj-yy2
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/8sw-xa3-2tn
title: Cota altissima (L.) J. Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/a77-lv3-n4m
title: Cota altissima (L.) J. Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/nxb-6ts-85a
title: Barleria tetracantha Balf. fil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/av6-vqq-jmr
title: Guatteria australis A. St.-Hil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/gn8-wwx-drk
title: Guatteria australis A. St.-Hil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bhb-35l-mdl
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/6n7-dhc-xvx
title: Cota altissima (L.) J. Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/gcc-ak0-ngn
title: Bellis perennis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/574-nj5-6qx
title: Cota altissima (L.) J. Gay

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/gf0-a5x-6vz
title: Thunbergia ruspolii Lindau

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/j4c-g67-xka
title: Epidendrum nocturnum Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.17632/kkcdg2c5cx
title: The Leading Role of Bank Supply Shocks

description: This replication package accompanies the paper titled The Leading Role of Bank Supply Shocks. It includes all necessary code and synthetic datasets to reproduce the core results and robustness checks, excluding confidential data components.
DOI: 10.3535/3je-yg3-1a8
title: Epidendrum × foulquieri Chiron

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/pzs-c4s-6hm
title: Epidendrum ciliare L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/g21-vep-b45
title: Epidendrum ciliare L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ktq-cwj-xrf
title: Epidendrum ciliare L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.17632/kkcdg2c5cx.1
title: The Leading Role of Bank Supply Shocks

description: This replication package accompanies the paper titled The Leading Role of Bank Supply Shocks. It includes all necessary code and synthetic datasets to reproduce the core results and robustness checks, excluding confidential data components.
DOI: 10.3535/n80-a1b-xfq
title: Strobilanthes renschiae (Bremek.) J. R. I. Wood & J. R. Benn.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/xfn-4kw-4t5
title: Epidendrum × foulquieri Chiron

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/27h-xe6-n87
title: Strobilanthes papillosa T. Anderson

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/6he-45n-q2m
title: Thyrsacanthus Nees

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/e75-53k-dxa
title: Bellardia viscosa (L.) Fisch. & C. A. Mey.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/1q5-827-4bn
title: Bellardia viscosa (L.) Fisch. & C. A. Mey.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/spl-ta1-7vp
title: Bellardia viscosa (L.) Fisch. & C. A. Mey.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/5ce-y23-mp4
title: Guatteria scytophylla Diels

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/we4-n7w-krq
title: Guatteria schomburgkiana Mart.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/p69-fbc-rel
title: Epidendrum angustilobum Fawc. & Rendle

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/z83-gkd-l97
title: Epidendrum nocturnum Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/2xm-als-5f5
title: Epidendrum nocturnum Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/qs2-pls-31b
title: Synedrellopsis grisebachii Hieron. & Kuntze

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/9hb-lsp-qxs
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/lnl-8lv-w43
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.m2pa77
title: Occurrence Download

description: A dataset containing 304 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Dermanura cinereum Gervais, 1856"
 ]
}

 The dataset includes 304 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0113337-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/rjf-73d-fa7
title: Bifora radians M. Bieb.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wqz-jr9-pdk
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/rmb-96f-7fg
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bvb-69e-5hm
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/sv3-f4g-a4x
title: Bifora radians M. Bieb.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/1pp-mpm-djk
title: Bifora radians M. Bieb.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/cjr-7dx-msh
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/23p-ggc-vwe
title: Guatteria subsessilis Mart.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/q3h-qpa-wce
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/386-zyk-jcz
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/k1h-50j-6mx
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ath-cbx-fgv
title: Guatteria punctata (Aubl.) R. A. Howard

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/6vs-4tl-tjw
title: Thunbergia lancifolia T. Anderson

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hab-c4m-bya
title: Bellardia viscosa (L.) Fisch. & C. A. Mey.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/1gl-qvl-wft
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/z6c-6dd-3v0
title: Thunbergia mildbraediana Lebrun & Touss.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/jcg-0ed-0hq
title: Epidendrum × foulquieri Chiron

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/yew-frt-pvk
title: Thunbergia mauginii Fiori

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/lrt-y6r-898
title: Epidendrum cocornocturnum Hágsater

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/8dt-82e-thx
title: Epidendrum mesocarpum Hágsater

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/e56-5ln-14q
title: Epidendrum nocturnum Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/rcb-1q7-xs2
title: Epidendrum angustilobum Fawc. & Rendle

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/t0r-wj9-zmj
title: Epidendrum nocturnum Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bc7-d6f-pjv
title: Epidendrum tridens Poepp. & Endl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mnr-y17-tal
title: Epidendrum mesocarpum Hágsater

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/y67-4wq-qfa
title: Epidendrum nocturnum Jacq.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/1zs-9jv-d4h
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/kqq-by6-7lg
title: Epidendrum longicolle Lindl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/84a-xlq-ndg
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/8yk-ed8-1fs
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/qxd-khx-ngl
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/5c7-z1z-wlb
title: Guatteria ouregou (Aubl.) Dunal

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/kgn-b4c-5dj
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/3hq-99x-pdh
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/neh-3rq-k0n
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/e3v-05s-xdk
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/wqy-r08-gj1
title: Guatteria ouregou (Aubl.) Dunal

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/9wk-jan-e6f
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/j8p-c8h-h1y
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/dln-pvh-axr
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bq4-9xr-vgd
title: Bellardia trixago (L.) All.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/vx1-222-jb7
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.6084/m9.figshare.28956854
title: Scripts for manuscript "Low amplitude copy number gains shape cancer through known and novel oncogenes with associated therapeutic vulnerabilities"

description: <b>Abstract:</b>Large chromosomal copy number gains are ubiquitous throughout cancer types. However, which genes drive their selective advantage is not well established, and therefore they are hardly utilized in clinical practice. Our analysis of copy number patterns in pan-cancer datasets suggests that the selective advantage of copy number gains is largely driven by known oncogenes. Analysis of CRISPR screening data identifies a list of 101 genes that are likely to mediate the effect of these gains, which is highly enriched in annotated oncogenes but also contains genes that have not been implicated in cancer so far. Moreover, we show that specific gains are associated with drug sensitivity or resistance, with a strong enrichment of gains of oncogenes with increased sensitivity to inhibitors targeting these specific genes. Finally, we provide examples where gains can function as relevant clinical biomarkers for diagnosis and treatment. Thus, large copy number gains exert their selective advantage through known and novel oncogenes and their systematic analysis could advance precision oncology.<br><b>Description</b>This share contains the R-scripts used to generate the figures and supplementary figures from the mentioned manuscript. All the neccesary packages and custom functions can be found in the Functions and Packages script. Intermediate files and other necessary files can be found in the intermediate_files ZIP file. Source files (segmented CN data, drug screening data, CRISPR screening data etc.) is <b>not </b>included but can be downloaded from the respective sources (Supplementary Table 1).
DOI: 10.6084/m9.figshare.28956854.v1
title: Scripts for manuscript "Low amplitude copy number gains shape cancer through known and novel oncogenes with associated therapeutic vulnerabilities"

description: <b>Abstract:</b>Large chromosomal copy number gains are ubiquitous throughout cancer types. However, which genes drive their selective advantage is not well established, and therefore they are hardly utilized in clinical practice. Our analysis of copy number patterns in pan-cancer datasets suggests that the selective advantage of copy number gains is largely driven by known oncogenes. Analysis of CRISPR screening data identifies a list of 101 genes that are likely to mediate the effect of these gains, which is highly enriched in annotated oncogenes but also contains genes that have not been implicated in cancer so far. Moreover, we show that specific gains are associated with drug sensitivity or resistance, with a strong enrichment of gains of oncogenes with increased sensitivity to inhibitors targeting these specific genes. Finally, we provide examples where gains can function as relevant clinical biomarkers for diagnosis and treatment. Thus, large copy number gains exert their selective advantage through known and novel oncogenes and their systematic analysis could advance precision oncology.<br><b>Description</b>This share contains the R-scripts used to generate the figures and supplementary figures from the mentioned manuscript. All the neccesary packages and custom functions can be found in the Functions and Packages script. Intermediate files and other necessary files can be found in the intermediate_files ZIP file. Source files (segmented CN data, drug screening data, CRISPR screening data etc.) is <b>not </b>included but can be downloaded from the respective sources (Supplementary Table 1).
DOI: 10.3535/gsf-qf1-tph
title: Bifora testiculata (L.) Roth

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.