cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14272/kcaxryjmufapld-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) (ethyl 3-azido-1-benzylpyrazole-4-carboxylate)
title: InChI=1S/C13H13N5O2/c1-2-20-13(19)11-9-18(16-12(11)15-17-14)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3

description: dataset for infrared absorption spectroscopy (IR)
 
 IR (ATR, ṽ) = 2980 (w), 2143 (vs), 1704 (vs), 1628 (w), 1608 (w), 1547 (vs), 1487 (vs), 1455 (s), 1438 (s), 1421 (m), 1397 (m), 1378 (s), 1354 (m), 1312 (vs), 1252 (w), 1215 (vs), 1188 (vs), 1112 (m), 1081 (vs), 1071 (vs), 1030 (vs), 1003 (m), 870 (m), 837 (m), 820 (m), 773 (vs), 708 (vs), 694 (s), 647 (m), 618 (w), 586 (m), 555 (w), 541 (w), 518 (w), 489 (w), 472 (w), 456 (w), 401 (w), 385 (w) cm–1.
DOI: 10.14272/kcaxryjmufapld-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (ethyl 3-azido-1-benzylpyrazole-4-carboxylate)
title: InChI=1S/C13H13N5O2/c1-2-20-13(19)11-9-18(16-12(11)15-17-14)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, Chloroform-d [77.0 ppm], ppm) δ = 162.4, 141.3, 139.7, 135.5, 128.8 (2C), 128.2, 127.6 (2C), 105.0, 60.4, 52.2, 14.4.
DOI: 10.14272/kcaxryjmufapld-uhfffaoysa-n.1
title: 3-azido-1-benzyl-pyrazole-4-carboxylic acid ethyl ester
title: InChI=1S/C13H13N5O2/c1-2-20-13(19)11-9-18(16-12(11)15-17-14)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C13H13N5O2/c1-2-20-13(19)11-9-18(16-12(11)15-17-14)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3, and canonical SMILES descriptor[cheminf_000007]: CCOC(=O)c1cn(nc1N=[N+]=[N-])Cc1ccccc1, and by the IUPAC name[cheminf_000107]: ethyl 3-azido-1-benzylpyrazole-4-carboxylate.
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-17825

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000470 | mass spectrometry (MS)
 
 CHMO:0000630 | infrared absorption spectroscopy (IR)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.14272/kcaxryjmufapld-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (ethyl 3-azido-1-benzylpyrazole-4-carboxylate)
title: InChI=1S/C13H13N5O2/c1-2-20-13(19)11-9-18(16-12(11)15-17-14)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, Chloroform-d [7.27 ppm], ppm) δ = 7.84 (s, 1H), 7.37–7.28 (m, 3H), 7.26–7.23 (m, 2H), 5.19 (s, 2H), 4.33 (q, J = 7.2 Hz, 2H), 1.37 (t, J = 7.2 Hz, 3H).
DOI: 10.14272/kjpmfogunjzonn-uhfffaoysa-n/chmo0000597
title: 19F nuclear magnetic resonance spectroscopy (19F NMR) ()
title: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2

description: dataset for 19F nuclear magnetic resonance spectroscopy (19F NMR)
 
 19F NMR (376 MHz, ppm) δ = -112.04.
DOI: 10.14272/kjpmfogunjzonn-uhfffaoysa-n/chmo0000470
title: mass spectrometry (MS) ()
title: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2

description: dataset for mass spectrometry (MS)
 
 MS (EI, 70 eV, 80 °C), m/z (%): 242 (13) [M]+, 109 (100), 83 (10).HRMS–EI (C11H7N6F) (m/z): [M]+ Calcd 242.0711; Found 242.0712.
DOI: 10.14272/kjpmfogunjzonn-uhfffaoysa-n/chmo0000630
title: infrared absorption spectroscopy (IR) ()
title: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2

description: dataset for infrared absorption spectroscopy (IR)
 
 IR (ATR, ṽ) = 3126 (m), 3067 (w), 2918 (w), 2849 (w), 2376 (w), 2230 (vs), 2146 (s), 2106 (s), 1892 (w), 1604 (w), 1541 (s), 1510 (s), 1476 (vs), 1438 (vs), 1419 (m), 1388 (w), 1377 (s), 1358 (s), 1324 (w), 1299 (w), 1254 (s), 1221 (vs), 1150 (vs), 1120 (s), 1095 (m), 1018 (m), 1000 (m), 948 (w), 850 (vs), 833 (vs), 824 (s), 769 (vs), 732 (vs), 686 (vs), 635 (s), 619 (vs), 577 (s), 528 (m), 518 (m), 506 (s), 482 (vs), 456 (w), 422 (s), 395 (vs) cm–1.
DOI: 10.14272/kjpmfogunjzonn-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) ()
title: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, Chloroform-d [7.27 ppm], ppm) δ = 7.61 (s, 1H), 7.31–7.27 (m, 2H), 7.13–7.08 (m, 2H), 5.18 (s, 2H).
DOI: 10.14272/kjpmfogunjzonn-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) ()
title: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, Chloroform-d [77.0 ppm], ppm) δ = 163.0 (d, J = 249 Hz), 150.6, 135.4, 130.2 (d, J = 8.5 Hz, 2C), 129.6 (d, J = 3.9 Hz), 116.2 (d, J = 21.6 Hz, 2C), 111.2, 84.0, 56.3.
DOI: 10.14272/kjpmfogunjzonn-uhfffaoysa-n.1
title: 3-azido-1-(4-fluorobenzyl)-1H-pyrazole-4-carbonitrile
title: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C11H7FN6/c12-10-3-1-8(2-4-10)6-18-7-9(5-13)11(16-18)15-17-14/h1-4,7H,6H2, and canonical SMILES descriptor[cheminf_000007]: [N-]=[N+]=Nc1nn(cc1C#N)Cc1ccc(cc1)F, and by the IUPAC name[cheminf_000107]: .
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-17856

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000597 | 19F nuclear magnetic resonance spectroscopy (19F NMR)
 
 CHMO:0000470 | mass spectrometry (MS)
 
 CHMO:0000630 | infrared absorption spectroscopy (IR)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.6084/m9.figshare.8093444
title: Additional file 4: of Hierarchical cooperation of transcription factors from integration analysis of DNA sequences, ChIP-Seq and ChIA-PET data

description: CalculationÂ for the maximal cliques for the fused matrix of TFs in different cell types, the specific TF in each maximal clique for the four cell lines is listed. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8093444.v1
title: Additional file 4: of Hierarchical cooperation of transcription factors from integration analysis of DNA sequences, ChIP-Seq and ChIA-PET data

description: CalculationÂ for the maximal cliques for the fused matrix of TFs in different cell types, the specific TF in each maximal clique for the four cell lines is listed. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8093483
title: Additional file 2: of Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates

description: Data Set 1. Neoantigens predicted based on patient-specific HLA genotypes in colorectal, melanoma, gastric, and uterine cancers. (ZIP 63724 kb)
DOI: 10.6084/m9.figshare.14384951.v1
title: Pre-optimized phage therapy on secondary <i>Acinetobacter baumannii</i> infection in four critical COVID-19 patients

description: Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) infections to compassionate phage therapy (at 2 successive doses of 10<sup>9</sup> plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients.
DOI: 10.6084/m9.figshare.8093501.v1
title: Additional file 3: of Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates

description: Table S1. Mutation profiles of BLS genes in colorectal, melanoma, gastric, and uterine cancers. Table S2. Ď (dN/dS ratio) and neutrality tests for selection signal of neoantigen carrying genes in BLS I only and Others group. Syn: synonymous mutation; mis: missense mutation; non: nonsense mutation. w: Ď (dN/dS ratio); p: P-values for substitutions are obtained by Likelihood-Ratio Tests as described in (Martincorena et al., 2017); q: q-values are obtained by Benjamini-Hodgbergâ s multiple testing correction. (XLS 12882 kb)
DOI: 10.6084/m9.figshare.22767312.v1
title: Additional file 2 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

description: Additional file 2. Containing DIABLO results by COPD status.
DOI: 10.6084/m9.figshare.22767315.v1
title: Additional file 3 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

description: Additional file 3. Containing DIABLO results by HIV status.
DOI: 10.6084/m9.figshare.22767315
title: Additional file 3 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

description: Additional file 3. Containing DIABLO results by HIV status.
DOI: 10.6084/m9.figshare.22767449
title: Additional file 3 of Transcriptomic profiling of near-isogenic lines reveals candidate genes for a significant locus conferring metribuzin resistance in wheat

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.22767452
title: Additional file 4 of Transcriptomic profiling of near-isogenic lines reveals candidate genes for a significant locus conferring metribuzin resistance in wheat

description: Supplementary Material 4
DOI: 10.6084/m9.figshare.22767318.v1
title: Additional file 4 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

description: Additional file 4. Containing DIABLO results by COPD and HIV status.
DOI: 10.6084/m9.figshare.22767458
title: Additional file 6 of Transcriptomic profiling of near-isogenic lines reveals candidate genes for a significant locus conferring metribuzin resistance in wheat

description: Supplementary Material 6
DOI: 10.6084/m9.figshare.21201075.v1
title: Comparative transcriptome analysis of different tissues of Rheum tanguticum Maxim. ex Balf. (Polygonaceae) reveals putative genes involved in anthraquinone biosynthesis

description: Abstract Rheum tanguticum is a perennial herb and an important medicinal plant, with anthraquinones as its main bioactive compounds. However, the specific pathway of anthraquinone biosynthesis in rhubarb is still unclear. The accumulation of anthraquinones in different tissues (root, leaf, stem and seed) of R. tanguticum revealed considerable variation, suggesting possible differences in metabolite biosynthetic pathways and accumulation among various tissues. To better illustrate the biosynthetic pathway of anthraquinones, we assembled transcriptome sequences from the root, leaf, stem and seed tissues yielding 157,564 transcripts and 88,142 unigenes. Putative functions could be assigned to 56,911 unigenes (64.57%) based on BLAST searches against annotation databases, including GO, KEGG, Swiss-Prot, NR, and Pfam. In addition, putative genes involved in the biosynthetic pathway of anthraquinone were identified. The expression profiles of nine unigenes involved in anthraquinone biosynthesis were verified in different tissues of R. tanguticum by qRT-PCR. Various transcription factors, including bHLH, MYB_related, and C2H2, were identified by searching unigenes against plantTFDB. This is the first transcriptome analysis of different tissues of R. tanguticum and can be utilized to describe the genes involved in the biosynthetic pathway of anthraquiones, understanding the molecular mechanism of active compounds in R. tanguticum.
DOI: 10.6084/m9.figshare.6530339
title: Additional file 2: of Intrachromosomal colocalization strengthens co-expression, co-modification and evolutionary conservation of neighboring genes

description: Table S2. Always-neighboring gene pairs without intrachromosomal colocalization. (XLSX 295 kb)
DOI: 10.6084/m9.figshare.14385055.v1
title: Additional file 1 of IgG and IgM antibody formation to spike and nucleocapsid proteins in COVID-19 characterized by multiplex immunoblot assays

description: Additional file 1. provides details of the calculations of the estimated clinical parameters of the detection of IgG and IgM antibodies in COVID-19 immunoblots.
DOI: 10.6084/m9.figshare.14385055
title: Additional file 1 of IgG and IgM antibody formation to spike and nucleocapsid proteins in COVID-19 characterized by multiplex immunoblot assays

description: Additional file 1. provides details of the calculations of the estimated clinical parameters of the detection of IgG and IgM antibodies in COVID-19 immunoblots.
DOI: 10.6084/m9.figshare.24356550
title: A new <i>Rattus</i> species and its associated micromammals from the Pliocene Yangyi Formation in Baoshan, western Yunnan, China

description: <i>Rattus</i> (sensu stricto) is one of the groups of rodents and is most closely related to human activities. The diversity of extant <i>Rattus</i> species is the highest among rodents, but fossil species are rare, mainly found in Asia during the Late Pliocene to Early Pleistocene. Here, we described a Late Pliocene new species of <i>Rattus</i> based on material from the upper Yangyi Formation in Baoshan county, Yunnan Province, China. The primitive morphological characteristics of fewer molar roots, t12 preserved on M1<i>–</i>2, t9 preserved on M3, and buccal stylids well developed on lower molars indicate that the new <i>Rattus</i> is by far the most primitive form in the <i>Rattus</i> genus. In dental morphology of <i>Rattus</i>, the molars have an evolutionary trend of gradually increasing the number of roots and fusing cusps into an arched ridge, reduction to disappearance of the t7 and t12 on upper molars, and reduction to disappearance of the mesiocentral cusp on m1, the anterior buccal stylid on m1–3 and hypoconid on m3. Discovery of the new <i>Rattus</i> from Baoshan confirms that <i>Rattus</i> probably originated in southern Asia before the Late Pliocene, and also provides new fossil evidence to calibrate the molecular clock of the divergence of <i>Rattus</i> from other murines. In addition, we also reported five associated small mammals: <i>Neotetracus</i> sp. nov., <i>Anourosorex qianensis</i>, Soricidae gen. et sp. indet., <i>Ia io</i>, and <i>Kowalskia</i> sp. Most of them inhabit warm and humid tropical or subtropical montane forests or shrubland environments. The composition of this mammalian assemblage indicates that the paleoelevation and paleoclimate of Baoshan area in the Pliocene are very similar to those of the present.
DOI: 10.6084/m9.figshare.24356550.v1
title: A new <i>Rattus</i> species and its associated micromammals from the Pliocene Yangyi Formation in Baoshan, western Yunnan, China

description: <i>Rattus</i> (sensu stricto) is one of the groups of rodents and is most closely related to human activities. The diversity of extant <i>Rattus</i> species is the highest among rodents, but fossil species are rare, mainly found in Asia during the Late Pliocene to Early Pleistocene. Here, we described a Late Pliocene new species of <i>Rattus</i> based on material from the upper Yangyi Formation in Baoshan county, Yunnan Province, China. The primitive morphological characteristics of fewer molar roots, t12 preserved on M1<i>–</i>2, t9 preserved on M3, and buccal stylids well developed on lower molars indicate that the new <i>Rattus</i> is by far the most primitive form in the <i>Rattus</i> genus. In dental morphology of <i>Rattus</i>, the molars have an evolutionary trend of gradually increasing the number of roots and fusing cusps into an arched ridge, reduction to disappearance of the t7 and t12 on upper molars, and reduction to disappearance of the mesiocentral cusp on m1, the anterior buccal stylid on m1–3 and hypoconid on m3. Discovery of the new <i>Rattus</i> from Baoshan confirms that <i>Rattus</i> probably originated in southern Asia before the Late Pliocene, and also provides new fossil evidence to calibrate the molecular clock of the divergence of <i>Rattus</i> from other murines. In addition, we also reported five associated small mammals: <i>Neotetracus</i> sp. nov., <i>Anourosorex qianensis</i>, Soricidae gen. et sp. indet., <i>Ia io</i>, and <i>Kowalskia</i> sp. Most of them inhabit warm and humid tropical or subtropical montane forests or shrubland environments. The composition of this mammalian assemblage indicates that the paleoelevation and paleoclimate of Baoshan area in the Pliocene are very similar to those of the present.
DOI: 10.6084/m9.figshare.14919455
title: Estimation of Knots in Linear Spline Models

description: The linear spline model is able to accommodate nonlinear effects while allowing for an easy interpretation. It has significant applications in studying threshold effects and change-points. However, its application in practice has been limited by the lack of both rigorously studied and computationally convenient method for estimating knots. A key difficulty in estimating knots lies in the nondifferentiability. In this article, we study influence functions of regular and asymptotically linear estimators for linear spline models using the semiparametric theory. Based on the theoretical development, we propose a simple semismooth estimating equation approach to circumvent the nondifferentiability issue using modified derivatives, in contrast to the previous smoothing-based methods. Without relying on any smoothing parameters, the proposed method is computationally convenient. To further improve numerical stability, a two-step algorithm taking advantage of the analytic solution available when knots are known is developed to solve the proposed estimating equation. Consistency and asymptotic normality are rigorously derived using the empirical process theory. Simulation studies have shown that the two-step algorithm performs well in terms of both statistical and computational properties and improves over existing methods. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.12812491
title: Additional file 3 of Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma

description: Additional file 3.
DOI: 10.6084/m9.figshare.12812488
title: Additional file 2 of Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma

description: Additional file 2.
DOI: 10.6084/m9.figshare.12812389.v1
title: Additional file 10 of A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk

description: Additional file 10. Distribution of SNP rs140618127 in different cohorts
DOI: 10.6084/m9.figshare.22767446.v1
title: Additional file 2 of Transcriptomic profiling of near-isogenic lines reveals candidate genes for a significant locus conferring metribuzin resistance in wheat

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.7579748.v1
title: Genome-wide DNA methylation and transcriptomic profiles in the lifestyle strategies and asexual development of the forest fungal pathogen <i>Heterobasidion parviporum</i>

description: <i>Heterobasidion parviporum</i> is the most devastating fungal pathogen of conifer forests in Northern Europe. The fungus has dual life strategies, necrotrophy on living trees and saprotrophy on dead woods. DNA cytosine methylation is an important epigenetic modification in eukaryotic organisms. Our presumption is that the lifestyle transition and asexual development in <i>H. parviporum</i> could be driven by epigenetic effects. Involvements of DNA methylation in the regulation of aforementioned processes have never been studied thus far. RNA-seq identified lists of highly induced genes enriched in carbohydrate-active enzymes during necrotrophic interaction with host trees and saprotrophic sawdust growth. It also highlighted signaling- and transcription factor-related genes potentially associated with the transition of saprotrophic to necrotrophic lifestyle and groups of primary cellular activities throughout asexual development. Whole-genome bisulfite sequencing revealed that DNA methylation displayed pronounced preference in CpG dinucleotide context across the genome and mostly targeted transposable element (TE)-rich regions. TE methylation level demonstrated a strong negative correlation with TE expression, reinforcing the protective function of DNA methylation in fungal genome stability. Small groups of genes putatively subject to methylation transcriptional regulation in response to saprotrophic and necrotrophic growth in comparison with free-living mycelia were also explored. Our study reported on the first methylome map of a forest pathogen. Analysis of transcriptome and methylome variations associated with asexual development and different lifestyle strategies provided further understanding of basic biological processes in <i>H. parviporum</i>. More importantly, our work raised additional potential roles of DNA methylation in fungi apart from controlling the proliferation of TEs.