cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20337332.v1
title: EFFECTS OF AEROBIC EXERCISE ON BODY MORPHOLOGY IN OBESE UNIVERSITY STUDENTS

description: ABSTRACT Introduction The problem of obesity is relevant to the current social development model. In addition to the eminent physical health risks, obese university students also experience greater resistance to social development. Obese students participating in the national weight loss fitness program can perceive the benefits of aerobic exercise. Objective Explore the effect of aerobic exercise on body morphology in obese university students. Methods 60 obese university students were selected as study subjects and divided equally into a control and experimental group. The control group received no intervention, while the experimental group performed a battery of aerobic exercises of 60 minutes daily, four times a week for six weeks. Data before and after the experiment were compared. BMI, body fat rate, blood lipid monitoring, and blood glucose were also taken as body component monitoring indexes, and circumference measurements and proportions were taken as external body monitoring indexes. Results Aerobic exercise can effectively reduce the body weight, body mass index (BMI), body fat rate, and body circumference of college students, decrease body weight, make the body shape more symmetrical, and also improve lipid and glycemic components, thus reducing the complications caused by obesity. Conclusion University professors should perform aerobic training for university students to improve their physical fitness, regulate their physical function, and improve their physical appearance. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
DOI: 10.6084/m9.figshare.20337333
title: Natura Goes Shopping: The Case of an Emerging Market Multinational

description: ABSTRACT This teaching case explores a unique international trajectory of an emerging market multinational in the cosmetics, fragrances, and toiletries industry. Natura &Co presents two very different internationalization strategies in two distinct moments: the first decisions seem to follow the gradual and incremental model described as the Uppsala model; later on, the company moves toward a more daring approach, explained by the springboard perspective, as it enters a series of large international acquisitions. The case is originally designed for disciplines of international business and international strategy at the graduate level and explores the above-mentioned theories, internationalization motives, and entry modes.
DOI: 10.6084/m9.figshare.20337333.v1
title: Natura Goes Shopping: The Case of an Emerging Market Multinational

description: ABSTRACT This teaching case explores a unique international trajectory of an emerging market multinational in the cosmetics, fragrances, and toiletries industry. Natura &Co presents two very different internationalization strategies in two distinct moments: the first decisions seem to follow the gradual and incremental model described as the Uppsala model; later on, the company moves toward a more daring approach, explained by the springboard perspective, as it enters a series of large international acquisitions. The case is originally designed for disciplines of international business and international strategy at the graduate level and explores the above-mentioned theories, internationalization motives, and entry modes.
DOI: 10.6084/m9.figshare.20337335
title: Predictive Ability of Cardiopulmonary Exercise Test Parameters in Heart Failure Patients with Cardiac Resynchronization Therapy

description: Abstract Background There is evidence suggesting that a peak oxygen uptake (pVO2) cut-off of 10ml/kg/min provides a more precise risk stratification in cardiac resynchronization therapy (CRT) patients. Objective To compare the prognostic power of several cardiopulmonary exercise testing (CPET) parameters in this population and assess the discriminative ability of the guideline-recommended pVO2cut-off values. Methods Prospective evaluation of consecutive heart failure (HF) patients with left ventricular ejection fraction ≤40%. The primary endpoint was a composite of cardiac death and urgent heart transplantation (HT) in the first 24 follow-up months, and was analysed by several CPET parameters for the highest area under the curve (AUC) in the CRT group. A survival analysis was performed to evaluate the risk stratification provided by several different cut-offs. p values &lt;0.05 were considered significant. Results A total of 450 HF patients, of which 114 had a CRT device. These patients had a higher baseline risk profile, but there was no difference regarding the primary outcome (13.2% vs 11.6%, p =0.660). End-tidal carbon dioxide pressure at anaerobic threshold (PETCO2AT)had the highest AUC value, which was significantly higher than that of pVO2in the CRT group (0.951 vs 0.778, p =0.046). The currently recommended pVO2cut-off provided accurate risk stratification in this setting (p &lt;0.001), and the suggested cut-off value of 10 ml/min/kg did not improve risk discrimination in device patients (p =0.772). Conclusion PETCO2ATmay outperform pVO2’s prognostic power for adverse events in CRT patients. The current guideline-recommended pVO2 cut-off can precisely risk-stratify this population.
DOI: 10.6084/m9.figshare.20337335.v1
title: Predictive Ability of Cardiopulmonary Exercise Test Parameters in Heart Failure Patients with Cardiac Resynchronization Therapy

description: Abstract Background There is evidence suggesting that a peak oxygen uptake (pVO2) cut-off of 10ml/kg/min provides a more precise risk stratification in cardiac resynchronization therapy (CRT) patients. Objective To compare the prognostic power of several cardiopulmonary exercise testing (CPET) parameters in this population and assess the discriminative ability of the guideline-recommended pVO2cut-off values. Methods Prospective evaluation of consecutive heart failure (HF) patients with left ventricular ejection fraction ≤40%. The primary endpoint was a composite of cardiac death and urgent heart transplantation (HT) in the first 24 follow-up months, and was analysed by several CPET parameters for the highest area under the curve (AUC) in the CRT group. A survival analysis was performed to evaluate the risk stratification provided by several different cut-offs. p values &lt;0.05 were considered significant. Results A total of 450 HF patients, of which 114 had a CRT device. These patients had a higher baseline risk profile, but there was no difference regarding the primary outcome (13.2% vs 11.6%, p =0.660). End-tidal carbon dioxide pressure at anaerobic threshold (PETCO2AT)had the highest AUC value, which was significantly higher than that of pVO2in the CRT group (0.951 vs 0.778, p =0.046). The currently recommended pVO2cut-off provided accurate risk stratification in this setting (p &lt;0.001), and the suggested cut-off value of 10 ml/min/kg did not improve risk discrimination in device patients (p =0.772). Conclusion PETCO2ATmay outperform pVO2’s prognostic power for adverse events in CRT patients. The current guideline-recommended pVO2 cut-off can precisely risk-stratify this population.
DOI: 10.6084/m9.figshare.20337336
title: Nursing protocol for children with sickle cell disease in emergency room: a convergent-care approach

description: ABSTRACT Objective: to describe the methodological process of developing a nursing care protocol for children with sickle cell disease in the emergency room. Method: convergent care research, carried out in a public pediatric hospital in the state of Bahia, with 12 emergency nurses specialist. Data production took place between July 2020 and April 2021, with semi-structured interviews, observation in a field diary and convergence groups, according to the research phases: conception, instrumentation, scrutiny and analysis. Results: The final result was the construction of a nursing care protocol for children with sickle cell disease in the emergency room for use in the study field. Final considerations: the Convergent Care Research proved to be an excellent methodological procedure for intervention in the health service, whose nursing care protocol was based on the reflections of professionals on evidence-based practices, whose consensus can enable safe and quality care.
DOI: 10.6084/m9.figshare.20337336.v1
title: Nursing protocol for children with sickle cell disease in emergency room: a convergent-care approach

description: ABSTRACT Objective: to describe the methodological process of developing a nursing care protocol for children with sickle cell disease in the emergency room. Method: convergent care research, carried out in a public pediatric hospital in the state of Bahia, with 12 emergency nurses specialist. Data production took place between July 2020 and April 2021, with semi-structured interviews, observation in a field diary and convergence groups, according to the research phases: conception, instrumentation, scrutiny and analysis. Results: The final result was the construction of a nursing care protocol for children with sickle cell disease in the emergency room for use in the study field. Final considerations: the Convergent Care Research proved to be an excellent methodological procedure for intervention in the health service, whose nursing care protocol was based on the reflections of professionals on evidence-based practices, whose consensus can enable safe and quality care.
DOI: 10.6084/m9.figshare.20337342
title: Single-center, retrospective study on changes in pain-relieving therapy after bone metastasis detection by bone scintigraphy in prostate cancer patients

description: Abstract Whole-body bone scintigraphy (WB-BS) is used for detecting and monitoring metastatic spread of prostate cancer (PCa) and to investigate bone pain episodes. To investigate the impact of a positive WB-BS on pain-relieving medicine prescription in PCa patients, a single-center, retrospective cohort study with PCa patients classified as positive for bone metastases (BM) by WB-BS was conducted. Demographic, clinical, and ambulatory pain-relieving medicine prescription data were evaluated. Pain-relieving medicines were categorized according to the WHO ‘Analgesic Ladder’. Regimens adopted before and after WB-BS were compared. Differences were considered significant at p&lt;0.05. A total of 180 PCa patients were diagnosed with BM, 64.4% of whom were ≥65 years of age. Thirty-three patients were prescribed analgesics only after WB-BS, mostly including NSAIDs and weak opioids. Pain-relieving prescription changed after WB-BS in patients with prescriptions before and after WB-BS, with a reduction in NSAIDs and adjuvants and an increase in weak and strong opioids. In addition, 40% of patients with WHO analgesic step 1 drugs and 21.7% of patients with WHO step 2 drugs before WB-BS changed to other WHO steps after WB-BS. Pain-relieving prescriptions changed after a positive WB-BS, providing evidence that it could contribute to clinical management of painful metastatic PCa patients.
DOI: 10.6084/m9.figshare.20337342.v1
title: Single-center, retrospective study on changes in pain-relieving therapy after bone metastasis detection by bone scintigraphy in prostate cancer patients

description: Abstract Whole-body bone scintigraphy (WB-BS) is used for detecting and monitoring metastatic spread of prostate cancer (PCa) and to investigate bone pain episodes. To investigate the impact of a positive WB-BS on pain-relieving medicine prescription in PCa patients, a single-center, retrospective cohort study with PCa patients classified as positive for bone metastases (BM) by WB-BS was conducted. Demographic, clinical, and ambulatory pain-relieving medicine prescription data were evaluated. Pain-relieving medicines were categorized according to the WHO ‘Analgesic Ladder’. Regimens adopted before and after WB-BS were compared. Differences were considered significant at p&lt;0.05. A total of 180 PCa patients were diagnosed with BM, 64.4% of whom were ≥65 years of age. Thirty-three patients were prescribed analgesics only after WB-BS, mostly including NSAIDs and weak opioids. Pain-relieving prescription changed after WB-BS in patients with prescriptions before and after WB-BS, with a reduction in NSAIDs and adjuvants and an increase in weak and strong opioids. In addition, 40% of patients with WHO analgesic step 1 drugs and 21.7% of patients with WHO step 2 drugs before WB-BS changed to other WHO steps after WB-BS. Pain-relieving prescriptions changed after a positive WB-BS, providing evidence that it could contribute to clinical management of painful metastatic PCa patients.
DOI: 10.6084/m9.figshare.20337345
title: APPLICATION OF ATHLETIC TRAINING IN THE FIELD FOR UNIVERSITY STUDENTS

description: ABSTRACT Introduction There was a delay in China for the implementation of athletic physical training, often opting for technical and repetitive movements in their teaching method, resulting in an unsatisfactory didactic model. Objective Innovate physical training technology for teaching athletics in colleges and universities. Methods 80 students in two college and university athletics sports classes were submitted to two weekly athletics classes lasting 60 minutes. This paper measured and collected data before and after the battery of exercises, comparing the results pertinent to the group’s physical fitness. All training lasted eight weeks. After this period, the relevant indices were measured again, ranked, and compared. Results The research shows that physical training can improve students’ athletic performance in different grades, and the effect of athletic gain in students with lower initial performance is more significant. At the same time, strengthening physical training can effectively improve the basal performance of athletics and reduce the occurrence of sports injuries, ensuring the safety of the sports experienced. Conclusion Physical training can promote positive performance in athletics, deserving further research to popularize the implementation of athletic training in athletics for colleges and universities. Level of evidence II; Therapeutic studies - investigation of treatment results.
DOI: 10.6084/m9.figshare.20337345.v1
title: APPLICATION OF ATHLETIC TRAINING IN THE FIELD FOR UNIVERSITY STUDENTS

description: ABSTRACT Introduction There was a delay in China for the implementation of athletic physical training, often opting for technical and repetitive movements in their teaching method, resulting in an unsatisfactory didactic model. Objective Innovate physical training technology for teaching athletics in colleges and universities. Methods 80 students in two college and university athletics sports classes were submitted to two weekly athletics classes lasting 60 minutes. This paper measured and collected data before and after the battery of exercises, comparing the results pertinent to the group’s physical fitness. All training lasted eight weeks. After this period, the relevant indices were measured again, ranked, and compared. Results The research shows that physical training can improve students’ athletic performance in different grades, and the effect of athletic gain in students with lower initial performance is more significant. At the same time, strengthening physical training can effectively improve the basal performance of athletics and reduce the occurrence of sports injuries, ensuring the safety of the sports experienced. Conclusion Physical training can promote positive performance in athletics, deserving further research to popularize the implementation of athletic training in athletics for colleges and universities. Level of evidence II; Therapeutic studies - investigation of treatment results.
DOI: 10.25934/pr00005794.12
title: Available IPD datapackage for study 'A Phase III, Open-Label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared With Docetaxel in Patients With Non-Small Cell Lung Cancer After Failure With Platinum Containing Chemotherapy'

description: This global, multicenter, open-label, randomized, controlled study evaluated the efficacy and safety of atezolizumab (an anti-programmed death−ligand 1 [anti-PD-L1] antibody)compared with docetaxel in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure with platinum-containing chemotherapy. Participants were randomized 1:1 to receive either docetaxel or atezolizumab. Treatment may continue as long as participants experienced clinical benefit as assessed by the investigator, i.e., in the absence of unacceptable toxicity or symptomatic deterioration attributed to disease progression.
DOI: 10.6084/m9.figshare.20337360
title: Financial Management in Practice: Analysis of Brazilian Survey Data

description: ABSTRACT Objective: this article replicates in Brazil a survey - previously applied in North America and Europe - to inquire CFOs about the cost of capital, capital budgeting, and capital structure. Method: we rigorously translated and validated the questionnaire before administering it over the internet. We delivered the questionnaire to 1,699 Brazilian private and public firms and received 160 responses, with a return rate of 9.4%. We analyzed the responses conditioned to firm characteristics. Results: the results of the financial policy survey in Brazil indicate that firms employ NPV and IRR as preferred investment techniques and the CAPM and its variations as the method for computing the cost of equity capital. They are also concerned with the cost of debt and transaction costs of market instruments, and they use internal funds as their main investment funding source. The conditional analysis indicates that large, listed, and regulated firms behave differently regarding financial decisions than their counterparts. Conclusion: the main takeaway from this study is that the institutional environment (markets, institutions, instruments, and the economy) is an important determinant of the practice of corporate finance.
DOI: 10.6084/m9.figshare.20337360.v1
title: Financial Management in Practice: Analysis of Brazilian Survey Data

description: ABSTRACT Objective: this article replicates in Brazil a survey - previously applied in North America and Europe - to inquire CFOs about the cost of capital, capital budgeting, and capital structure. Method: we rigorously translated and validated the questionnaire before administering it over the internet. We delivered the questionnaire to 1,699 Brazilian private and public firms and received 160 responses, with a return rate of 9.4%. We analyzed the responses conditioned to firm characteristics. Results: the results of the financial policy survey in Brazil indicate that firms employ NPV and IRR as preferred investment techniques and the CAPM and its variations as the method for computing the cost of equity capital. They are also concerned with the cost of debt and transaction costs of market instruments, and they use internal funds as their main investment funding source. The conditional analysis indicates that large, listed, and regulated firms behave differently regarding financial decisions than their counterparts. Conclusion: the main takeaway from this study is that the institutional environment (markets, institutions, instruments, and the economy) is an important determinant of the practice of corporate finance.
DOI: 10.6084/m9.figshare.20337374
title: Suitability of methods for Plasmodium falciparum cultivation in atmospheric air

description: BACKGROUND One of the most controversial factors about malaria parasite culture is the gaseous composition used. The most commonly used one consists of a mixture poor in O2 and rich in CO2. OBJECTIVES The present study aimed to share standard methods from our research group simplifying Plasmodium falciparum cultures by employing atmospheric air (ATM) and reusable glass bottles under agitation. METHODS Here, it was compared the parasite viability, free oxygen in media, and drug sensitivity between different strains and isolates maintained for long periods under ATM or classic conditions. FINDINGS The oxygen concentration in media under ATM was slightly superior to that observed in human blood and the media under the classic gaseous mixture. However, ATM or the use of glass bottles did not affect parasitic proliferation after several years of culture. Noticeably, the introduction of ATM altered reversibly the efficacy of several antimalarials. This influence was different between the strains and isolate. CONCLUSIONS ATM conditions and shaken flasks could be used as a standard method condition for culture manutention since they do not differ greatly from classical 5% O2 gas mixtures in terms of parasite proliferation and do not impose non-reversible changes to P. falciparum physiology.
DOI: 10.6084/m9.figshare.20337374.v1
title: Suitability of methods for Plasmodium falciparum cultivation in atmospheric air

description: BACKGROUND One of the most controversial factors about malaria parasite culture is the gaseous composition used. The most commonly used one consists of a mixture poor in O2 and rich in CO2. OBJECTIVES The present study aimed to share standard methods from our research group simplifying Plasmodium falciparum cultures by employing atmospheric air (ATM) and reusable glass bottles under agitation. METHODS Here, it was compared the parasite viability, free oxygen in media, and drug sensitivity between different strains and isolates maintained for long periods under ATM or classic conditions. FINDINGS The oxygen concentration in media under ATM was slightly superior to that observed in human blood and the media under the classic gaseous mixture. However, ATM or the use of glass bottles did not affect parasitic proliferation after several years of culture. Noticeably, the introduction of ATM altered reversibly the efficacy of several antimalarials. This influence was different between the strains and isolate. CONCLUSIONS ATM conditions and shaken flasks could be used as a standard method condition for culture manutention since they do not differ greatly from classical 5% O2 gas mixtures in terms of parasite proliferation and do not impose non-reversible changes to P. falciparum physiology.
DOI: 10.6084/m9.figshare.20337372.v1
title: A MATHEMATICAL OPTIMIZATION APPROACH BASED ON LINEARIZED MIP MODELS FOR SOLVING FACILITY LAYOUT PROBLEMS

description: ABSTRACT One of the strategies used to optimize production processes is to define the best layout. For this, the relative positioning of the various equipment, areas, or functional activities inside the company is studied. Proper arrangement of facilities will result in shorter process times and higher productivity. In general, the objective function of the facility layout problem (FLP) is to reduce the total material handling cost. Although over six decades have been passed since the first work on FLP modeling was published, research on many aspects of this problem is still in an early stage and needs to be further explored, which motivated this study. In this paper, the unequal area of rectangular blocks with fixed dimensions and input/output points are considered for FLPs. Four new mixed-integer programming (MIP) models based on previous research formulations are developed. Then, a mathematical optimization approach based on the linearization of the models is applied. An algorithm that solves the linearized MIP model by CPLEX setting a time limit for the solution obtained excellent results for different test problems when compared to those reported in the literature.