cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11968068.v1
title: Supplementary Material for: Clinical Benefit Derived from Decitabine Therapy for Advanced Phases of Myeloproliferative Neoplasms

description: Treatment options are limited for patients with advanced forms of myeloproliferative neoplasms (MPN) including blast-phase disease (MPN-BP). Decitabine has frequently been deployed but its efficacy and safety profile are not well described in this population. We retrospectively reviewed 42 patients treated with decitabine either alone or in combination with ruxolitinib at our institution: 16 with MPN-BP, 14 with MPN accelerated-phase (MPN-AP), and 12 with myelofibrosis with high-risk features (MF-HR). The median overall survival (OS) for the MPN-BP patients was 2.6 months, and for those who received ≥2 cycles of decitabine therapy, it was 6.7 months (3.8–29.8). MPN-BP patients with a poor performance status and who required hospitalization at the time of the initiation of decitabine had a dismal prognosis. After a median follow-up of 12.4 months for MPN-AP patients, and 38.7 months for MF-HR patients, the median OS was not reached for either cohort, with 1 and 2 patients alive at 60 months, respectively. The probability of spleen length reduction and transfusion independence within 12 months of initiating decitabine was 28.6 and 23.5%, respectively. The combination of decitabine and ruxolitinib appeared to improve overall survival versus single-agent decitabine (21 and 12.9 months, respectively). Decitabine, alone or in combination with ruxolitinib, appears to have clinical benefit for patients with advanced phases of MPN when initiated early in the disease course prior to the development of MPN-BP.
DOI: 10.6084/m9.figshare.11968059.v1
title: Based on Multi-dimensional Software Data for Code Smell Detection

description: \noindent Code smell is the product of improper design and operation, which may be introduced in many situations. It will cause problems for further development and maintenance. Currently, most code smells detection tools detect through a single type of data, and are primarily based on software structured data. There are restrictions on detecting code smells with complex definitions and characteristics. In this paper, we propose a method of applying complex network technology combined with multi-dimensional software data, which can comprehensively use more and richer software data. We designed two smells detection strategies and evaluated them in four open source projects. Judging from the results, we demonstrate that our approach has 23% and 15% higher F-measures on Shotgun Surgery and Parallel Inheritance Hierarchy than the existing most advanced detection tools. The detection method based on multi-dimensional software data and complex network is effective. This software network also provides guidance for data-driven software research.
DOI: 10.6084/m9.figshare.11968059.v2
title: Based on Multi-dimensional Software Data for Code Smell Detection

description: Code smell is the product of improper design and operation, which may be introduced in many situations. It will cause problems for further development and maintenance. Currently, most code smells detection tools detect through a single type of data, and are primarily based on software structured data. There are restrictions on detecting code smells with complex definitions and characteristics. In this paper, we propose a method of applying complex network technology combined with multi-dimensional software data, which can comprehensively use more and richer software data. We designed two smells detection strategies and evaluated them in four open source projects. Judging from the results, we demonstrate that our approach has 23% and 15% higher F-measures on Shotgun Surgery and Parallel Inheritance Hierarchy than the existing most advanced detection tools. The detection method based on multi-dimensional software data and complex network is effective. This software network also provides guidance for data-driven software research.
DOI: 10.6084/m9.figshare.11968059.v4
title: None

description: Kill you 3 days.
DOI: 10.6084/m9.figshare.11968059.v3
title: Based on Multi-dimensional Software Data and Complex Networks for Code Smells Detection

description: Code smell is the product of improper design and operation, which may be introduced in many situations. It will cause problems for further software development and maintenance. Currently, most code smells detection tools detect through a single type of software data. There are restrictions on detecting code smells with complex definitions and characteristics. In this paper, we propose a method of applying multi-dimensional software data. This method builds complex network through structural data and historical version data, and determines the code smell instances by searching the network. We designed two smells detection strategies and evaluated them in four open source projects. Judging from the results, we demonstrate that our approach has 23% and 15% higher F-measures on Shotgun Surgery and Parallel Inheritance Hierarchy than the existing most advanced detection tools. The detection method based on multi-dimensional software data and complex network is effective, and this software network can also provides guidance for data-driven software research.
DOI: 10.6084/m9.figshare.11967924
title: Metadata record for: A global database of Holocene paleotemperature records

description: This dataset contains key characteristics about the data described in the Data Descriptor A global database of Holocene paleotemperature records. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <br> <br>
DOI: 10.6084/m9.figshare.11967915
title: L2 Section, Sample 22. 52 Year Old Female

description: A 3 mm thick para-sagittal slice of L2 vertebra from an 52 year old female embedded in PMMA then micro-milled block surfaces carbon coated for quantitative 20kV BSE SEM.<br><br>Later polished to remove coating and then imaged with high-contrast X-Ray Micro-tomography at 90 kV with 30 micron voxel size.<br><br>
DOI: 10.6084/m9.figshare.11967921
title: L2 Section, Sample 24. 81 Year Old Female

description: A 3 mm thick para-sagittal slice of L2 vertebra from an 81 year old female embedded in PMMA then micro-milled block surfaces carbon coated for quantitative 20kV BSE SEM.<br><br>Later polished to remove coating and then imaged with high-contrast X-Ray Micro-tomography at 90 kV with 30 micron voxel size.
DOI: 10.6084/m9.figshare.11967897
title: L2 Section, Sample 19. 24 Year Old Female

description: A 3 mm thick para-sagittal slice of L2 vertebra from an 24 year old female embedded in PMMA then micro-milled block surfaces carbon coated for quantitative 20kV BSE SEM.<br><br>Later polished to remove coating and then imaged with high-contrast X-Ray Micro-tomography at 90 kV with 30 micron voxel size.<br><br>There is also a 3D VR model of this sample available :<br>https://skfb.ly/6QSAJ<br>
DOI: 10.6084/m9.figshare.11967870
title: Supplementary Material for: Effect of Cashew Nut on Lipid Profile: A Systematic Review and Meta-Analysis

description: <b><i>Introduction:</i></b> Nuts are one of the dietary components which appear to have beneficial effects on cardiovascular disease biomarkers. Studies demonstrate beneficial effects of cash­ews on serum lipids concentration, but results in the literature remain inconclusive. We conducted a review to examine the effects of cashew nut supplementation on serum lipid profile. <b><i>Methods:</i></b> Two reviewers independently searched PubMed, Web of Science, Cochrane Library, Scopus, and EMBASE electronic databases from inception until June 2019 without language limitation. Random- and fixed-effects models were used to calculate 95% confidence intervals (CI) for studies. <b><i>Results:</i></b> Six randomized clinical trials comprising 531 participants were included in this systematic review. Three studies were included in the meta-analysis model. There were no significant changes for total cholesterol (TC) (standardized mean difference [SMD]: –0.02, 95% CI: –0.32, 0.28), triglycerides (TG) (SMD: –0.01, 95% CI: –0.22, 0.20), high-density lipoprotein (HDL) cholesterol (SMD: 0.09, 95% CI: –0.16, 0.34), or low-density lipoprotein (LDL) cholesterol (SMD: –0.18, 95% CI: –0.75, 0.39). <b><i>Conclusion:</i></b> The results of this analysis demonstrate that treatment with cashew nut supplementation alone did not significantly change serum levels of LDL, HDL, TC, or TG.
DOI: 10.6084/m9.figshare.11967870.v1
title: Supplementary Material for: Effect of Cashew Nut on Lipid Profile: A Systematic Review and Meta-Analysis

description: <b><i>Introduction:</i></b> Nuts are one of the dietary components which appear to have beneficial effects on cardiovascular disease biomarkers. Studies demonstrate beneficial effects of cash­ews on serum lipids concentration, but results in the literature remain inconclusive. We conducted a review to examine the effects of cashew nut supplementation on serum lipid profile. <b><i>Methods:</i></b> Two reviewers independently searched PubMed, Web of Science, Cochrane Library, Scopus, and EMBASE electronic databases from inception until June 2019 without language limitation. Random- and fixed-effects models were used to calculate 95% confidence intervals (CI) for studies. <b><i>Results:</i></b> Six randomized clinical trials comprising 531 participants were included in this systematic review. Three studies were included in the meta-analysis model. There were no significant changes for total cholesterol (TC) (standardized mean difference [SMD]: –0.02, 95% CI: –0.32, 0.28), triglycerides (TG) (SMD: –0.01, 95% CI: –0.22, 0.20), high-density lipoprotein (HDL) cholesterol (SMD: 0.09, 95% CI: –0.16, 0.34), or low-density lipoprotein (LDL) cholesterol (SMD: –0.18, 95% CI: –0.75, 0.39). <b><i>Conclusion:</i></b> The results of this analysis demonstrate that treatment with cashew nut supplementation alone did not significantly change serum levels of LDL, HDL, TC, or TG.
DOI: 10.6084/m9.figshare.11967789.v1
title: Inshore hagfish genome assembly - Kuraku Lab

description: Genome assembly from which a non-embargoed gene model oriented for gene-level analysis was derived.<br>
DOI: 10.6084/m9.figshare.11967759
title: Synthesis, DFT study, molecular docking and insecticidal evaluation of some pyrazole-based tetrahydropyrimidine derivatives

description: The building block synthon, 1-(4-(1,3-diphenyl-1<i>H</i>-pyrazol-4-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethan-1-one was efficiently synthesized by Biginelli reaction of 1,3-diphenyl-1<i>H</i>-pyrazole-4-carbaldehdye, acetylacetone, and thiourea and submitted to react with ethyl chloroacetate and chloroacetyl chloride under different conditions to afford some <i>N</i>-heterocycles integrated with pyrazole scaffold. Hydrazinolysis of the pyrimidinethione was studied under different conditions. The insecticidal activity for these compounds, DFT calculations, and docking were run and discussed. Some of them exhibited 100% mortality against <i>Nilaparvata lugens</i> and <i>Mythimna separata</i>.
DOI: 10.6084/m9.figshare.11967765
title: Hyperfluidity of dry grain-crushing dense granular flow

description: The puzzle of the unexpectedly high mobility of large geophysical flows has been reported as solved many times since Albert Heim drew attention to it after a disastrous landslide at Elm, Switzerland.
DOI: 10.6084/m9.figshare.11967759.v1
title: Synthesis, DFT study, molecular docking and insecticidal evaluation of some pyrazole-based tetrahydropyrimidine derivatives

description: The building block synthon, 1-(4-(1,3-diphenyl-1<i>H</i>-pyrazol-4-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethan-1-one was efficiently synthesized by Biginelli reaction of 1,3-diphenyl-1<i>H</i>-pyrazole-4-carbaldehdye, acetylacetone, and thiourea and submitted to react with ethyl chloroacetate and chloroacetyl chloride under different conditions to afford some <i>N</i>-heterocycles integrated with pyrazole scaffold. Hydrazinolysis of the pyrimidinethione was studied under different conditions. The insecticidal activity for these compounds, DFT calculations, and docking were run and discussed. Some of them exhibited 100% mortality against <i>Nilaparvata lugens</i> and <i>Mythimna separata</i>.
DOI: 10.6084/m9.figshare.11967738
title: Supplementary Material for: Treatment Outcomes of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis in Patients Over Age 75 Years: A Meta-Analysis

description: <b><i>Background:</i></b> The benefits of treating anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) in advancing age remains unclear with most published studies defining elderly as ≥65 years. This study aims to determine outcomes of induction immunosuppression in patients aged ≥75 years. <b><i>Methods:</i></b> A cohort of patients aged ≥75 years with a diagnosis of AAV between 2006 and 2018 was constructed from 2 centres. Follow-up was to 2 years or death. Analysis included multivariable Cox regression to compare mortality and end-stage renal disease (ESRD) based on receipt of induction immunosuppression therapy with either cyclophosphamide or rituximab. A systematic review of outcome studies was subsequently undertaken amongst this patient group through Pubmed, Cochrane and Embase databases from inception until October 16, 2019. <b><i>Results:</i></b> Sixty-seven patients were identified. Mean age was 79 ± 2.9 years and 82% (<i>n</i> = 55) received induction immunosuppression. Following systematic review, 4 studies were eligible for inclusion, yielding a combined total of 290 patients inclusive of our cohort. The aggregated 1-year mortality irrespective of treatment was 31% (95% CI 25–36%). Within our cohort, induction immunosuppression therapy was associated with a significantly lower 2-year mortality risk (hazard ratio [HR] 0.29 [95% CI 0.09–0.93]). The pooled HR by meta-analysis confirmed this with a significant risk reduction for death (HR 0.31 [95% CI 0.16–0.57], <i>I</i><sup>2</sup> = 0%). Treated patients had a lower pooled rate of ESRD, but was not statistically significant (HR 0.71 [95% CI 0.15–3.35]). <b><i>Conclusion:</i></b> This meta-analysis suggests that patients ≥75 years with AAV do benefit from induction immunosuppression with a significant survival benefit. Age alone should not be a limiting factor when considering treatment.
DOI: 10.6084/m9.figshare.11967738.v1
title: Supplementary Material for: Treatment Outcomes of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis in Patients Over Age 75 Years: A Meta-Analysis

description: <b><i>Background:</i></b> The benefits of treating anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) in advancing age remains unclear with most published studies defining elderly as ≥65 years. This study aims to determine outcomes of induction immunosuppression in patients aged ≥75 years. <b><i>Methods:</i></b> A cohort of patients aged ≥75 years with a diagnosis of AAV between 2006 and 2018 was constructed from 2 centres. Follow-up was to 2 years or death. Analysis included multivariable Cox regression to compare mortality and end-stage renal disease (ESRD) based on receipt of induction immunosuppression therapy with either cyclophosphamide or rituximab. A systematic review of outcome studies was subsequently undertaken amongst this patient group through Pubmed, Cochrane and Embase databases from inception until October 16, 2019. <b><i>Results:</i></b> Sixty-seven patients were identified. Mean age was 79 ± 2.9 years and 82% (<i>n</i> = 55) received induction immunosuppression. Following systematic review, 4 studies were eligible for inclusion, yielding a combined total of 290 patients inclusive of our cohort. The aggregated 1-year mortality irrespective of treatment was 31% (95% CI 25–36%). Within our cohort, induction immunosuppression therapy was associated with a significantly lower 2-year mortality risk (hazard ratio [HR] 0.29 [95% CI 0.09–0.93]). The pooled HR by meta-analysis confirmed this with a significant risk reduction for death (HR 0.31 [95% CI 0.16–0.57], <i>I</i><sup>2</sup> = 0%). Treated patients had a lower pooled rate of ESRD, but was not statistically significant (HR 0.71 [95% CI 0.15–3.35]). <b><i>Conclusion:</i></b> This meta-analysis suggests that patients ≥75 years with AAV do benefit from induction immunosuppression with a significant survival benefit. Age alone should not be a limiting factor when considering treatment.
DOI: 10.6084/m9.figshare.11967729
title: OTU's table

description: OTU’s table after QIIME processing
DOI: 10.6084/m9.figshare.11967714
title: Hierarchical genetic structuring in the cool boreal kelp, Laminaria digitata: implications for conservation and management

description: Microsatellite genotypes for <i>Laminaria digitata </i>from sites throughout the NE Atlantic
DOI: 10.6084/m9.figshare.11967711
title: Supplementary Material for: The Association between Aortic Valve Weight, Echocardiographic Indices, and All-Cause Death in 1,046 Patients Undergoing Surgical Aortic Valve Replacement for Aortic Stenosis

description: <b><i>Background:</i></b> Aortic valve weight (AVW), a flow independent measure of aortic stenosis (AS) severity, is reported to have heterogeneous associations with the echocardiographic variables used for AS evaluation. Controversy exists regarding its impact on survival after aortic valve replacement (AVR). <b><i>Objective:</i></b> We sought to determine the association between AVW with echocardiographic measures of AS severity and all-cause mortality after surgical AVR. <b><i>Methods:</i></b> One thousand and forty-six<b><i></i></b>consecutive patients underwent surgical AVR for AS, the excised valves were weighed, and an echocardiogram was done before surgery. <b><i>Results:</i></b> Males had heavier valves than females, for both absolute and body surface are (BSA)-indexed values (2.78 ± 1.23 vs. 2.08 ± 0.68 g, <i>p</i> &lt; 0.001; and 1.38 ± 0.61 vs. 1.19 ± 0.41 g/m<sup>2</sup>, <i>p</i> &lt; 0.001, respectively). In a restricted cohort of 634 patients with isolated severe AS and normal ejection fraction, the correlations of AVW with echocardiographic variables of AS were modest, the strongest being with the dimensionless index (<i>r</i> = <b><i>–</i></b>0.27 and <b><i>–</i></b>0.26 for male and female, both <i>p</i> &lt; 0.01). Stratified by stroke volume index and mean gradient (MG), no associations were found in the low-gradient groups (i.e., MG &lt;40 mm<b><i></i></b>Hg). At a median follow-up of 3.5 years, there were only 244 deaths in the entire cohort. Mortality was not related to AVW, except in females who displayed an inverse relationship (HR = 0.67; 95% CI 0.47<b><i>–</i></b>0.95) only when it was analyzed as a continuous variable. <b><i>Conclusions:</i></b> The weak correlation between AVW with the echocardiographic indices of AS may reflect its complex pathophysiology, heterogeneous hemodynamics, and possible pitfalls in the current echocardiographic methods used in clinical practice. The prognostic value of AVW after AVR warrants further evaluation.
DOI: 10.6084/m9.figshare.11967711.v1
title: Supplementary Material for: The Association between Aortic Valve Weight, Echocardiographic Indices, and All-Cause Death in 1,046 Patients Undergoing Surgical Aortic Valve Replacement for Aortic Stenosis

description: <b><i>Background:</i></b> Aortic valve weight (AVW), a flow independent measure of aortic stenosis (AS) severity, is reported to have heterogeneous associations with the echocardiographic variables used for AS evaluation. Controversy exists regarding its impact on survival after aortic valve replacement (AVR). <b><i>Objective:</i></b> We sought to determine the association between AVW with echocardiographic measures of AS severity and all-cause mortality after surgical AVR. <b><i>Methods:</i></b> One thousand and forty-six<b><i></i></b>consecutive patients underwent surgical AVR for AS, the excised valves were weighed, and an echocardiogram was done before surgery. <b><i>Results:</i></b> Males had heavier valves than females, for both absolute and body surface are (BSA)-indexed values (2.78 ± 1.23 vs. 2.08 ± 0.68 g, <i>p</i> &lt; 0.001; and 1.38 ± 0.61 vs. 1.19 ± 0.41 g/m<sup>2</sup>, <i>p</i> &lt; 0.001, respectively). In a restricted cohort of 634 patients with isolated severe AS and normal ejection fraction, the correlations of AVW with echocardiographic variables of AS were modest, the strongest being with the dimensionless index (<i>r</i> = <b><i>–</i></b>0.27 and <b><i>–</i></b>0.26 for male and female, both <i>p</i> &lt; 0.01). Stratified by stroke volume index and mean gradient (MG), no associations were found in the low-gradient groups (i.e., MG &lt;40 mm<b><i></i></b>Hg). At a median follow-up of 3.5 years, there were only 244 deaths in the entire cohort. Mortality was not related to AVW, except in females who displayed an inverse relationship (HR = 0.67; 95% CI 0.47<b><i>–</i></b>0.95) only when it was analyzed as a continuous variable. <b><i>Conclusions:</i></b> The weak correlation between AVW with the echocardiographic indices of AS may reflect its complex pathophysiology, heterogeneous hemodynamics, and possible pitfalls in the current echocardiographic methods used in clinical practice. The prognostic value of AVW after AVR warrants further evaluation.
DOI: 10.6084/m9.figshare.11967714.v2
title: Hierarchical genetic structuring in the cool boreal kelp, Laminaria digitata: implications for conservation and management

description: Microsatellite genotypes for <i>Laminaria digitata </i>from sites throughout the NE Atlantic
DOI: 10.6084/m9.figshare.11967702
title: TableS1.xlsx

description: OTU’s table after QIIME processing includes list of identified bacteria at the lowest taxonomic level.
DOI: 10.6084/m9.figshare.11967714.v1
title: Hierarchical genetic structuring in the cool boreal kelp, Laminaria digitata: implications for conservation and management

description: Microsatellite genotypes for <i>Laminaria digitata </i>from sites throughout the NE Atlantic
DOI: 10.6084/m9.figshare.11967699
title: Recognition list from Reviewers in 2019

description: Recognition list
DOI: 10.6084/m9.figshare.11967702.v2
title: TableS1.xlsx

description: OTU’s table after QIIME processing includes list of identified bacteria at the lowest taxonomic level.
DOI: 10.6084/m9.figshare.11967699.v1
title: Recognition list from Reviewers in 2019

description: Recognition list
DOI: 10.6084/m9.figshare.11967702.v1
title: TableS1.xlsx

description: OTU’s table after QIIME processing includes list of identified bacteria at the lowest taxonomic level.