DOI: 10.5061/dryad.80gb5mkx1
title: Data from: Pulsed peritoneal dialysis in Sprague-Dawley rats

description: Peritoneal dialysis treatment is hampered by low small solute clearances
 compared to hemodialysis. Previous data have indicated that stirring or
 mixing of the dialysate could possibly improve small solute diffusion,
 presumably by avoiding the formation of stagnant layers in the dialysate
 directly adjacent to the peritoneal membrane. In an experimental model of
 peritoneal dialysis in Sprague-Dawley rats, we compared a 60 min standard
 PD-exhange with a novel exchange technique called pulsed peritoneal
 dialysis in which the dialysate in pulsed  in and out of the
 peritoneal cavity without the addition of fresh dialysis fluid. Samples of
 dialysate were taken directly after instillation and after 60 min. Samples
 of blood were taken before and after dialysis.
description: # Pulsed peritoneal dialysis in Sprague-Dawley rats
 [https://doi.org/10.5061/dryad.80gb5mkx1](https://doi.org/10.5061/dryad.80gb5mkx1) Principal Investigator Name: Carl M. Öberg ORCID: 0000-0002-2471-6914 Institution: Lund University Address: Njurmottagningen SUS Lund, Barngatan 2, 22184 Lund, SWEDEN Email: [Carl.Oberg@med.lu.se](mailto:Carl.Oberg@med.lu.se) Author/Associate or Co-investigator Information Name: Helén Axelberg ORCID: NA Institution: Lund University Address: NA Email: [Helen.Axelberg@med.lu.se](mailto:Helen.Axelberg@med.lu.se) Date of data collection: 2023-08-29 to 2023-10-12 Geographic location of data collection: Lund, Sweden ## Description of the data and file structure DATA-SPECIFIC INFORMATION FOR: ppd.csv Methods for processing the data: Saved as a CSV file from Microsoft Excel Number of variables: 96 Number of cases/animals: 24 Variable List: animal, "Unique number assigned to each rat" treatment, "Treatment/intervention given to the animal" date, "Date of the experiment YYYY-MM-DD" weight_before, "Body weight of the animal in grams before dialysis" weight_after, "Body weight of the animal in grams after dialysis" vin, "Peritoneal dialysis fluid volume instilled in milliliters" vout, "Peritoneal dialysis fluid volume extracted in milliliters (see manuscript for details)" wo_in, "Wash-out fluid instilled (same type of fluid as used for dialysis) in milliliters" wo_out, "Wash-out fluid extracted in milliliters" wo_alb, "Wash-out fluid 125-I activity in Bq/mL" u_glu, "Urine glucose in mmol/L (not measured)" uristix, "Urine glucose using dipstick test (not measured)" uvol, "Urine volume in μL" u_alb, "Urine I-125 activity in Bq" u_edta, "Urine 51-Cr activity in Bq" p_na_before, "Plasma sodium concentration before dialysis in mmol/L" p_k_before, "Plasma potassium concentration before dialysis in mmol/L" p_cl_before, "Plasma chloride concentration before dialysis in mmol/L" p_ica_before, "Plasma ionized calcium concentration before dialysis in mmol/L" p_tco2_before, "Plasma total carbon dioxide concentration before dialysis in mmol/L" p_glu_before, "Plasma glucose concentration before dialysis in mmol/L" p_urea_before, "Plasma urea concentration before dialysis in mmol/L" p_crea_before, "Plasma creatinine concentration before dialysis in mmol/L" map_before, "Mean arterial pressure before dialysis in mmol/L" hr_before, "Heart rate before dialysis in mmol/L" p_na_after, "Plasma sodium concentration after dialysis in mmol/L" p_k_after, "Plasma potassium concentration after dialysis in mmol/L" p_cl_after, "Plasma chloride concentration after dialysis in mmol/L" p_ica_after, "Plasma ionized calcium concentration after dialysis in mmol/L" p_tco2_after, "Plasma total carbon dioxide concentration before dialysis in mmol/L" p_glu_after, "Plasma glucose concentration after dialysis in mmol/L" p_urea_after, "Plasma urea concentration after dialysis in mmol/L" p_crea_after, "Plasma creatinine concentration after dialysis in mmol/L" map_after, "Mean arterial pressure before dialysis in mmol/L" hr_after, "Heart rate before dialysis in mmol/L" n_p_samples, "Number of blood samples obtained during dialysis" pt1, "Time point for blood sample #1 in minutes post start of dialysis" pt2, "Time point for blood sample #2 in minutes post start of dialysis" pt3, "Time point for blood sample #3 in minutes post start of dialysis" pt4, "Time point for blood sample #4 in minutes post start of dialysis" pt5, "Time point for blood sample #5 in minutes post start of dialysis" pt6, "Time point for blood sample #6 in minutes post start of dialysis" p_hct_1, "Hematocrit for blood sample #1" p_hct_2, "Hematocrit for blood sample #2" p_hct_3, "Hematocrit for blood sample #3" p_hct_4, "Hematocrit for blood sample #4" p_hct_5, "Hematocrit for blood sample #5" p_hct_6, "Hematocrit for blood sample #6" p_edta_1, "Plasma 51Cr activity (blood sample #1) in Bq/mL" p_edta_2, "Plasma 51Cr activity (blood sample #2) in Bq/mL" p_edta_3, "Plasma 51Cr activity (blood sample #3) in Bq/mL" p_edta_4, "Plasma 51Cr activity (blood sample #4) in Bq/mL" p_edta_5, "Plasma 51Cr activity (blood sample #5) in Bq/mL" p_edta_6, "Plasma 51Cr activity (blood sample #6) in Bq/mL" p_alb_1, "Plasma 125I activity (blood sample #1) in Bq/mL" p_alb_2, "Plasma 125I activity (blood sample #2) in Bq/mL" p_alb_3, "Plasma 125I activity (blood sample #3) in Bq/mL" p_alb_4, "Plasma 125I activity (blood sample #4) in Bq/mL" p_alb_5, "Plasma 125I activity (blood sample #5) in Bq/mL" p_alb_6, "Plasma 125I activity (blood sample #6) in Bq/mL" n_d_samples, "Number of dialysate samples obtained during dialysis" d_sv_1, "Sampling volume for dialysate sample #1 in milliliters" d_sv_2, "Sampling volume for dialysate sample #2 in milliliters" d_edta_0_1, "51Cr activity in fresh dialysis fluid (before instillation) in Bq/mL, first sample" d_edta_0_2, "51Cr activity in fresh dialysis fluid (before instillation) in Bq/mL, second sample" d_edta_0_3, "51Cr activity in fresh dialysis fluid (before instillation) in Bq/mL, third for sample" d_edta_1_1, "51Cr activity in dialysate (directly after instillation) in Bq/mL, first sample" d_edta_1_2, "51Cr activity in dialysate (directly after instillation) in Bq/mL, second sample" d_edta_1_3, "51Cr activity in dialysate (directly after instillation) in Bq/mL, third for sample" d_edta_2_1, "51Cr activity in dialysate (end of dialysis session) in Bq/mL, first sample" d_edta_2_2, "51Cr activity in dialysate (end of dialysis session) in Bq/mL, second sample" d_edta_2_3, "51Cr activity in dialysate (end of dialysis session) in Bq/mL, third for sample" d_alb_0_1, "125I activity in fresh dialysis fluid (before instillation) in Bq/mL, first sample" d_alb_0_2, "125I activity in fresh dialysis fluid (before instillation) in Bq/mL, second sample" d_alb_0_3, "125I activity in fresh dialysis fluid (before instillation) in Bq/mL, third for sample" d_alb_1_1, "125I activity in dialysate (directly after instillation) in Bq/mL, first sample" d_alb_1_2, "125I activity in dialysate (directly after instillation) in Bq/mL, second sample" d_alb_1_3, "125I activity in dialysate (directly after instillation) in Bq/mL, third for sample" d_alb_7_1, "125I activity in dialysate (end of dialysis session) in Bq/mL, first sample" d_alb_7_2, "125I activity in dialysate (end of dialysis session) in Bq/mL, second sample" d_alb_7_3, "125I activity in dialysate (end of dialysis session) in Bq/mL, third for sample" d_glu_1, "Measured glucose concentration in dialysate sample #1 in mmol/L" d_glu_7, "Measured glucose concentration in dialysate sample #7 in mmol/L" d_na_0, "Stock sodium concentration in fresh dialysis fluid in mmol/L" d_na_1, "Measured sodium concentration in dialysate sample #1 in mmol/L" d_na_7, "Measured sodium concentration in dialysate sample #7 in mmol/L" d_k_0, "Stock potassium concentration in fresh dialysis fluid in mmol/L" d_k_1, "Measured potassium concentration in dialysate sample #1 in mmol/L" d_k_7, "Measured potassium concentration in dialysate sample #7 in mmol/L" d_cl_0, "Stock chloride concentration in fresh dialysis fluid in mmol/L" d_cl_1, "Measured chloride concentration in dialysate sample #1 in mmol/L" d_cl_7, "Measured chloride concentration in dialysate sample #7 in mmol/L" d_ica_0, "Stock calcium ion concentration in fresh dialysis fluid in mmol/L" d_ica_1, "Measured ionized calcium concentration in dialysate sample #1 in mmol/L" d_ica_7, "Measured ionized calcium concentration in dialysate sample #7 in mmol/L" d_tco2_0, "Stock total carbon dioxide concentration in fresh dialysis fluid in mmol/L" d_tco2_1, "Measured total carbon dioxide concentration in dialysate sample #1 in mmol/L" d_tco2_7, "Measured total carbon dioxide concentration in dialysate sample #1 in mmol/L" d_urea_1, "Measured urea concentration in dialysate sample #1 in mmol/L" d_urea_7, "Measured urea concentration in dialysate sample #7 in mmol/L" d_crea_1, "Measured creatinine concentration in dialysate sample #2 in μmol/L" d_crea_7, "Measured creatinine concentration in dialysate sample #2 in μmol/L" dt1, "Time point for dialysate sample #1 in minutes post start of dialysis" dt7, "Time point for dialysate sample #7 in minutes post start of dialysis" Missing data codes: NA ## Sharing/Access information Licenses/restrictions placed on the data: No rights reserved (Creative Commons Zero, CC0) Links to publications that cite or use the data: NA Links to other publicly accessible locations of the data: NA Links/relationships to ancillary data sets: NA Was data derived from another source? No Recommended citation for this dataset: NA