cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29917375.v1
title: Clinical observation and immune effect of high-intensity focused ultrasound (HIFU) treatment on patients with colorectal cancer liver metastasis

description: This study evaluates the clinical and immune effects of high-intensity focused ultrasound (HIFU) on liver metastases from colorectal cancer (CRC). A retrospective analysis was conducted on 64 CRC patients with liver metastases treated with HIFU at Qingdao University’s HIFU Cancer Center. Variables such as sex, age, ECOG status, tumor location, KRAS mutation status, HBV infection, number and size of liver metastases, and previous systemic treatments were analyzed. The impact of systemic treatment lines on progression-free survival (PFS) and overall survival (OS) was assessed. A subgroup of 24 patients receiving HIFU combined with first-line therapy was matched with 21 patients receiving chemotherapy alone for comparison. Sixty-four patients underwent 69 HIFU treatments. Median survival was 52 months, with 1-year survival at 100%, 2-year survival at 93.3% and 3-year survival at 72%. The number of metastases treated with HIFU and systemic treatment lines significantly influenced survival (<i>p</i> &lt; 0.05). Post-treatment serum IL-6 levels decreased significantly (<i>p</i> &lt; 0.001). OS was significantly better in the HIFU + chemotherapy group compared to chemotherapy-only (<i>p</i> &lt; 0.0001). HIFU significantly improves OS in CRC liver metastasis patients and reduces serum IL-6 levels, suggesting enhanced immune responses.
DOI: 10.6084/m9.figshare.30529837.v1
title: Genomic evolution of high-risk soft tissue sarcomas under thermo- and chemotherapeutic selection pressure

description: The integration of regional hyperthermia into the multimodal treatment of patients with localized high-risk soft tissue sarcomas has been shown to improve overall survival. However, specific effects on the tumors’ genetic makeup and biology are largely unknown. Since clonal selection of malignant cells capable of thermoresistance might contribute to disease progression, a better understanding of the induced tumor evolution could inform strategies for improving treatment efficacy. We performed whole exome sequencing on paired sarcoma samples obtained before and after treatment with chemotherapy combined with regional hyperthermia (<i>n</i> = 12 patients; <i>n</i> = 9 paired samples, <i>n</i> = 3 post-treatment only). Tumor evolution was evident in all paired samples, with shifts in small- and large-scale genomic alterations. Overall, these alterations appeared tumor-specific, but recurrent mutations in histone H3-modifying genes were found exclusively in post-therapeutic samples. Our findings showcase the diversity of genomic evolution patterns in sarcomas emerging under combined thermo- and chemotherapeutic selection pressure, indicating that treatment response may vary according to the specific tumor composition. With previous studies linking histone functions to heat stress response, the alterations found in genes modifying H3 in our post-therapeutic cohort provide biological evidence for synergy of chemotherapy combined with regional hyperthermia in soft tissue sarcomas.
DOI: 10.6084/m9.figshare.30050205
title: Mechanistic insights into FUNDC2P4 and HSF1 regulation of EMT in residual hepatocellular carcinoma following insufficient radiofrequency ablation

description: Insufficient radiofrequency ablation (IRFA) increases the risk of hepatocellular carcinoma (HCC) recurrence and metastasis. Our previous study revealed that IRFA downregulates FUNDC2P4 and promotes epithelial-mesenchymal transition (EMT), but the mechanisms remain unclear. We simulated IRFA <i>in vitro</i> using a thermostatic water bath and assessed RNA and protein expression via qRT-PCR and Western blotting. Transcriptome analysis of LV-FUNDC2P4-transfected Huh7 cells, along with computational prediction, truncated mutants, and dual-luciferase assays, was performed to investigate the competitive binding of FUNDC2P4 and heat shock factor 1 (HSF1) to the Chromobox protein homolog 7 (CBX7) promoter. Functional assays, including CCK-8, Transwell, and wound-healing assays, evaluated cell proliferation, invasion, and migration. IRFA induced EMT, downregulated FUNDC2P4, and upregulated HSF1. Gene set enrichment analysis indicated EMT suppression in Huh7 cells overexpressing FUNDC2P4. Overexpression of FUNDC2P4 increased CBX7 expression, while HSF1 overexpression reduced it. Co-transfection led to moderate CBX7 levels. Two overlapping binding sites within the CBX7 promoter were identified: the FUNDC2P4 triplex target site (nucleotides 1782–1832) and the HSF1 binding site (nucleotides 1790–1804). Functional studies suggest that FUNDC2P4 may compete with HSF1 to transcriptionally regulate CBX7, which in turn suppresses EMT and modulates HCC cell proliferation, invasion, and metastasis. These findings suggest a potential regulatory mechanism involving FUNDC2P4 and HSF1 that may contribute to HCC recurrence and metastasis after IRFA, warranting further <i>in vivo</i> and clinical investigation.
DOI: 10.6084/m9.figshare.30050205.v1
title: Mechanistic insights into FUNDC2P4 and HSF1 regulation of EMT in residual hepatocellular carcinoma following insufficient radiofrequency ablation

description: Insufficient radiofrequency ablation (IRFA) increases the risk of hepatocellular carcinoma (HCC) recurrence and metastasis. Our previous study revealed that IRFA downregulates FUNDC2P4 and promotes epithelial-mesenchymal transition (EMT), but the mechanisms remain unclear. We simulated IRFA <i>in vitro</i> using a thermostatic water bath and assessed RNA and protein expression via qRT-PCR and Western blotting. Transcriptome analysis of LV-FUNDC2P4-transfected Huh7 cells, along with computational prediction, truncated mutants, and dual-luciferase assays, was performed to investigate the competitive binding of FUNDC2P4 and heat shock factor 1 (HSF1) to the Chromobox protein homolog 7 (CBX7) promoter. Functional assays, including CCK-8, Transwell, and wound-healing assays, evaluated cell proliferation, invasion, and migration. IRFA induced EMT, downregulated FUNDC2P4, and upregulated HSF1. Gene set enrichment analysis indicated EMT suppression in Huh7 cells overexpressing FUNDC2P4. Overexpression of FUNDC2P4 increased CBX7 expression, while HSF1 overexpression reduced it. Co-transfection led to moderate CBX7 levels. Two overlapping binding sites within the CBX7 promoter were identified: the FUNDC2P4 triplex target site (nucleotides 1782–1832) and the HSF1 binding site (nucleotides 1790–1804). Functional studies suggest that FUNDC2P4 may compete with HSF1 to transcriptionally regulate CBX7, which in turn suppresses EMT and modulates HCC cell proliferation, invasion, and metastasis. These findings suggest a potential regulatory mechanism involving FUNDC2P4 and HSF1 that may contribute to HCC recurrence and metastasis after IRFA, warranting further <i>in vivo</i> and clinical investigation.
DOI: 10.13140/rg.2.2.31031.59040
title: Measurement BioAbundance UVAura Far-UVC Lamp
DOI: 10.15468/dl.th3uv7
title: Occurrence Download

description: A dataset containing 49 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((6.98372 47.46521,7.96128 47.46521,7.96128 48.97388,6.98372 48.97388,6.98372 47.46521))",
 "TaxonKey is Buxbaumia"
 ]
}

 The dataset includes 49 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060191-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17026/ar/ohvj1c
title: PAN-00182736 - monochrome glass bead compressed spherical (antique)

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00182736&lt;/p&gt;
description: Modified: 2025-11-18T16:49:47+01:00
DOI: 10.15468/dl.yy2vhf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"GADM_LEVEL_0_GID","value":"ARG","matchCase":false},{"type":"equals","key":"GADM_LEVEL_1_GID","value":"ARG.3_1","matchCase":false},{"type":"equals","key":"GADM_LEVEL_2_GID","value":"ARG.3.8_1","matchCase":false},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060192-251120083545085/datasets/export for details.
DOI: 10.21227/xrjz-2836
title: "Maternal Mental Healthcare Screening Dataset"

description: "This dataset provides carefully crafted and organized maternal mental healthcare screening guidelines. It was extracted from well-tested questionnaires and screening tools and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), a comprehensive reference text used for the diagnosis and classification of mental disorders. The dataset consists of extracted text, which entails descriptions, classifications, and diagnostic criteria for a wide range of mental health disorders. This data covers many aspects including; definitions of various mental disorders, diagnostic criteria for each disorder, Symptoms and characteristic patterns of behavior associated with mental health conditions, Statistical information about prevalence and other related clinical data. The dataset supports research in computer NLP and inclusive healthcare technologies."
DOI: 10.25345/c5jw87176
title: MassIVE MSV000100286 - Exploring natural pesticides: metabolomic insights into wheat and barley response to scopoletin and umbelliferone
title: Incorporating a natural, eco-friendly approach allelopathy into integrated pest management can significantly reduce reliance on hazardous pesticides. This study examines the metabolic and physiological responses of wheat (Triticum aestivum) and barley (Hordeum vulgare) to the allelochemicals umbelliferone (UMB) and scopoletin (SCOP), evaluating their potential as biopesticides. Despite their demonstrated bioactivity, commercialization is hindered by limited understanding of their mechanisms of action, impact on non-target organisms, and cost-effectiveness. To address these challenges, a metabolomic approach was used to assess the effects of UMB and SCOP on important worldwide cereals crop and identify key metabolites involved in their responses. A metabolomic approach was used to compare their effects with conventional pesticides: 2,4-dichlorophenoxyacetic acid (2,4-D) and tebuconazole (1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol, TBC). Non-target LC-ESI-MS/MS and LC-Full-MS/ddMS2 analyses identified significant metabolite changes, while chemometric tools ensured robust data interpretation, which were validated by cross-validation and permutation testing, confirming the stability and predictive accuracy of the results. The findings showed that UMB minimally disrupts plant metabolism while activating key defense pathways, as evidenced by increased levels of fatty acids, auxins, and phytoalexins. Whereas, SCOP induced metabolic changes similar to those of the synthetic fungicide TBC, suggesting its potential as a natural fungicide alternative. These outcomes establish a robust framework for assessing the broader applicability of natural biopesticides, offering innovative and environmentally benign alternatives to synthetic pesticides while addressing pressing challenges in food security and environmental sustainability.
DOI: 10.15468/dl.qvzcfp
title: Occurrence Download

description: A dataset containing 363 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"GADM_LEVEL_0_GID","value":"ARG","matchCase":false},{"type":"equals","key":"GADM_LEVEL_1_GID","value":"ARG.3_1","matchCase":false},{"type":"equals","key":"GADM_LEVEL_2_GID","value":"ARG.3.9_1","matchCase":false},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 363 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060193-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17026/ar/kuv2yz
title: PAN-00177812 - terra sigillata bowl type Drag. 37

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00177812&lt;/p&gt;
description: Modified: 2025-11-18T10:58:05+01:00
DOI: 10.15468/dl.6fq3b2
title: Occurrence Download

description: A dataset containing 128291 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ciconia episcopus"
 ]
}

 The dataset includes 128291 records from 105 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060175-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25345/c5f47h73c
title: MassIVE MSV000100287 - Reductive_amination_retention_time_matching
title: MS/MS fragmentation data of fecal sample of RA acquired on Q Exactive - with chromatographic separation on a Phenomenex polar C18 column.
DOI: 10.15468/dl.8zg2cq
title: Occurrence Download

description: A dataset containing 1047919 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tracheophyta",
 "DecimalLatitude is greater than or equal to 0.0",
 "DecimalLatitude is less than or equal to 5.0",
 "DecimalLongitude is greater than or equal to -80.0",
 "DecimalLongitude is less than or equal to -75.0",
 "HasCoordinate is TRUE",
 "HasGeospatialIssue is FALSE"
 ]
}

 The dataset includes 1047919 records from 521 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060179-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x3jb8n
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"GADM_LEVEL_0_GID","value":"ARG","matchCase":false},{"type":"equals","key":"GADM_LEVEL_1_GID","value":"ARG.3_1","matchCase":false},{"type":"equals","key":"GADM_LEVEL_2_GID","value":"ARG.3.10_1","matchCase":false},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060195-251120083545085/datasets/export for details.
DOI: 10.5281/zenodo.17985602
title: Data supporting the manuscript "Universal single-copy genes and 16S rDNA present incongruent evolutionary histories in Vibrio"

description: DNA sequence alignments of genes used in Bayesian analysis of phylogenetic relationships among species in the bacterial genus Vibrio. 

bioRXiv preprint:  doi: https://doi.org/10.64898/2025.12.07.692777 

Changes: Readme.txt updated, DOI of preprint added, graphical abstract added, Supplementary Materials of preprint added.
DOI: 10.5281/zenodo.17789687
title: Data supporting the manuscript "Universal single-copy genes and 16S rDNA present incongruent evolutionary histories in Vibrio"

description: DNA sequence alignments of genes used in Bayesian analysis of phylogenetic relationships among species in the bacterial genus Vibrio. 

bioRXiv preprint:  doi: https://doi.org/10.64898/2025.12.07.692777 

Changes: Readme.txt updated, DOI of preprint added, graphical abstract added, Supplementary Materials of preprint added.
DOI: 10.6084/m9.figshare.30919313
title: <b>The Clinical Practice of Oral Medicine in South Africa: a description of referral sources and diseases managed in a private and public health facility</b>

description: <b>The Clinical Practice of Oral Medicine in South Africa: a description of referral sources and diseases managed in a private and public health facility</b>Oral medicine is a specialised discipline within periodontics in South Africa, focused on the diagnoses and management of oral mucosal diseases. Limited awareness may lead to underutilisation of oral medicine services. This study describes referral patterns, investigations, and disease profiles in public and private OM clinics in Gauteng. A retrospective review of patient records was conducted for a private oral medicine clinic (2016–2018) and a public oral medicine clinic (2021–2022). Data included demographics, referral sources, prior consultations, investigations, and diagnoses. A total of 522 patients were analysed (private: 309; public: 213). Most were female (private: 70.2%; public: 63.9%) with mean ages of 53 and 52 years. Dental practitioners were the main referral source (private: 69.3%; public: 65.3%), while medical referrals were limited (private: 22%; public: 10.8%). Patients often consulted multiple clinicians before oral medicine referral. Incisional biopsy was the most frequent investigation. Immune-mediated diseases predominated in both settings, while public clinics managed more benign growths, oral potentially malignant disorders, and infections. Oral medicine services are primarily accessed through dental referrals, with minimal medical engagement. Diagnostic delays and demographic disparities highlight the need for improved awareness, streamlined referral pathways, and equitable access.
DOI: 10.6084/m9.figshare.30919313.v1
title: <b>The Clinical Practice of Oral Medicine in South Africa: a description of referral sources and diseases managed in a private and public health facility</b>

description: <b>The Clinical Practice of Oral Medicine in South Africa: a description of referral sources and diseases managed in a private and public health facility</b>Oral medicine is a specialised discipline within periodontics in South Africa, focused on the diagnoses and management of oral mucosal diseases. Limited awareness may lead to underutilisation of oral medicine services. This study describes referral patterns, investigations, and disease profiles in public and private OM clinics in Gauteng. A retrospective review of patient records was conducted for a private oral medicine clinic (2016–2018) and a public oral medicine clinic (2021–2022). Data included demographics, referral sources, prior consultations, investigations, and diagnoses. A total of 522 patients were analysed (private: 309; public: 213). Most were female (private: 70.2%; public: 63.9%) with mean ages of 53 and 52 years. Dental practitioners were the main referral source (private: 69.3%; public: 65.3%), while medical referrals were limited (private: 22%; public: 10.8%). Patients often consulted multiple clinicians before oral medicine referral. Incisional biopsy was the most frequent investigation. Immune-mediated diseases predominated in both settings, while public clinics managed more benign growths, oral potentially malignant disorders, and infections. Oral medicine services are primarily accessed through dental referrals, with minimal medical engagement. Diagnostic delays and demographic disparities highlight the need for improved awareness, streamlined referral pathways, and equitable access.
DOI: 10.5281/zenodo.17985848
title: Data set Responden PENGARUH SERVANT LEADERSHIP, LEADER-MEMBER EXCHANGE, TRUST IN LEADERSHIP, DAN TRANSFORMAL LEADERSHIP TERHADAP PERILAKU INOVATIF KARYAWAN DENGAN PSYCHOLOGICAL SAFETY SEBAGAI MEDIATOR.
DOI: 10.5281/zenodo.17985849
title: Data set Responden PENGARUH SERVANT LEADERSHIP, LEADER-MEMBER EXCHANGE, TRUST IN LEADERSHIP, DAN TRANSFORMAL LEADERSHIP TERHADAP PERILAKU INOVATIF KARYAWAN DENGAN PSYCHOLOGICAL SAFETY SEBAGAI MEDIATOR.
DOI: 10.15468/dl.9pspdv
title: Occurrence Download

description: A dataset containing 112 species occurrences available in GBIF matching the query:
{"type":"and","predicates":[{"type":"equals","key":"GADM_LEVEL_0_GID","value":"ARG","matchCase":false},{"type":"equals","key":"GADM_LEVEL_1_GID","value":"ARG.3_1","matchCase":false},{"type":"equals","key":"GADM_LEVEL_2_GID","value":"ARG.3.12_1","matchCase":false},{"type":"equals","key":"CLASS_KEY","value":"212","matchCase":false},{"type":"greaterThanOrEquals","key":"YEAR","value":"2015","matchCase":false},{"type":"not","predicate":{"type":"in","key":"BASIS_OF_RECORD","values":["MATERIAL_CITATION","MATERIAL_SAMPLE","PRESERVED_SPECIMEN"],"matchCase":false}},{"type":"lessThanOrEquals","key":"COORDINATE_UNCERTAINTY_IN_METERS","value":"10000","matchCase":false},{"type":"equals","key":"LICENSE","value":"CC BY 4.0","matchCase":false}]}

 The dataset includes 112 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0060196-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.