cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30041137
title: Supplementary Material for: Discrepancies in treatment goals and concerns regarding disease management between patients with myeloproliferative neoplasms and hematologists in China: Analysis from a multicenter cross-sectional survey

description: Purpose: To identify the discrepancies in treatment goals and concerns regarding disease management between patients with myeloproliferative neoplasms (MPNs) and hematologists.
Methods: A study was conducted among patients with MPNs, including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF), and hematologists in China.
Results: Data from 1645 respondents with ET, PV, and MF and 715 hematologist respondents were analyzed. Cure of disease and healthy blood counts as treatment goals were reported more by almost half of the respondents with MPNs than by hematologists. However, prevention of thrombotic events, delayed transformation of disease, improvement of symptoms and better quality of life, and reduction in spleen size were less reported by respondents with MPNs than by hematologists. In multivariate analyses, education, comorbidities, symptom burden, disease duration, and annual out-of-pocket expenses for treatment were significantly associated with the treatment goals of respondents with MPNs. However, female physicians and senior professors paid more attention to these goals. Regarding concerns on MPN-related issues, more respondents with MPNs paid more attention to disease knowledge and restrictions in daily life compared to hematologists, whereas the majority of physicians attached importance to medication-related issues.
Conclusions: The perceptions of patients with MPNs and hematologists differed in terms of treatment goals and concerns of management of MPNs. Sociodemographic and clinical variables were associated with the respondents’ perspectives on MPNs. Therefore, sufficient patient–physician communication is suggested to improve treatment satisfaction and compliance.
DOI: 10.6084/m9.figshare.30041137.v1
title: Supplementary Material for: Discrepancies in treatment goals and concerns regarding disease management between patients with myeloproliferative neoplasms and hematologists in China: Analysis from a multicenter cross-sectional survey

description: Purpose: To identify the discrepancies in treatment goals and concerns regarding disease management between patients with myeloproliferative neoplasms (MPNs) and hematologists.
Methods: A study was conducted among patients with MPNs, including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF), and hematologists in China.
Results: Data from 1645 respondents with ET, PV, and MF and 715 hematologist respondents were analyzed. Cure of disease and healthy blood counts as treatment goals were reported more by almost half of the respondents with MPNs than by hematologists. However, prevention of thrombotic events, delayed transformation of disease, improvement of symptoms and better quality of life, and reduction in spleen size were less reported by respondents with MPNs than by hematologists. In multivariate analyses, education, comorbidities, symptom burden, disease duration, and annual out-of-pocket expenses for treatment were significantly associated with the treatment goals of respondents with MPNs. However, female physicians and senior professors paid more attention to these goals. Regarding concerns on MPN-related issues, more respondents with MPNs paid more attention to disease knowledge and restrictions in daily life compared to hematologists, whereas the majority of physicians attached importance to medication-related issues.
Conclusions: The perceptions of patients with MPNs and hematologists differed in terms of treatment goals and concerns of management of MPNs. Sociodemographic and clinical variables were associated with the respondents’ perspectives on MPNs. Therefore, sufficient patient–physician communication is suggested to improve treatment satisfaction and compliance.
DOI: 10.6084/m9.figshare.30041140
title: Supplementary Material for: Vitamin Profile of the Patients with Chronic Kidney Disease Receiving a Novel Total Parenteral Nutrition Formula: Multicenter Randomized Controlled Phase III Trial

description: Introduction: Efficacy and safety of a novel total parenteral nutrition formula for chronic kidney disease patients, OPF-109, containing multivitamins based on the FDA2000 recommendation were investigated.
Methods: We conducted a phase III clinical trial administering OPF-109 (n=63) or the control solutions (combination of marketed products including multivitamin based on American Medical Association 1975 guidelines) (n=61) to the chronic kidney disease patients for 8 days. Blood concentrations of proteins and vitamins and safety were evaluated. The primary efficacy endpoint was protein concentration (serum T-P, ALB, pre-ALB, transferrin) on Day8. Safety endpoints were hematological data, blood biochemistry data, vital signs, and adverse events.
Results: Values of blood protein until Day8 were similar in 2 groups although those of vitamins B1, B6, C, and folic acid (contained more in OPF-109) were higher in the OPF-109 group. For both groups, vitamin C concentration of Day1 was below the normal range, which restored to within the range in the OPF-109 group but decreased in the control group on Day8. Vitamin K concentration (contained less in OPF-109) was over the normal range on Day1 in both groups and decreased to slightly higher than the normal range in the OPF-109 group while increased to higher than Day1 value in the control group on Day8. Safety was similar in 2 groups.
Conclusion: Efficacy and safety of OPF-109 and usefulness of multivitamins based on the FDA 2000 recommendations formula were confirmed in chronic kidney disease patients.
DOI: 10.6084/m9.figshare.30041140.v1
title: Supplementary Material for: Vitamin Profile of the Patients with Chronic Kidney Disease Receiving a Novel Total Parenteral Nutrition Formula: Multicenter Randomized Controlled Phase III Trial

description: Introduction: Efficacy and safety of a novel total parenteral nutrition formula for chronic kidney disease patients, OPF-109, containing multivitamins based on the FDA2000 recommendation were investigated.
Methods: We conducted a phase III clinical trial administering OPF-109 (n=63) or the control solutions (combination of marketed products including multivitamin based on American Medical Association 1975 guidelines) (n=61) to the chronic kidney disease patients for 8 days. Blood concentrations of proteins and vitamins and safety were evaluated. The primary efficacy endpoint was protein concentration (serum T-P, ALB, pre-ALB, transferrin) on Day8. Safety endpoints were hematological data, blood biochemistry data, vital signs, and adverse events.
Results: Values of blood protein until Day8 were similar in 2 groups although those of vitamins B1, B6, C, and folic acid (contained more in OPF-109) were higher in the OPF-109 group. For both groups, vitamin C concentration of Day1 was below the normal range, which restored to within the range in the OPF-109 group but decreased in the control group on Day8. Vitamin K concentration (contained less in OPF-109) was over the normal range on Day1 in both groups and decreased to slightly higher than the normal range in the OPF-109 group while increased to higher than Day1 value in the control group on Day8. Safety was similar in 2 groups.
Conclusion: Efficacy and safety of OPF-109 and usefulness of multivitamins based on the FDA 2000 recommendations formula were confirmed in chronic kidney disease patients.
DOI: 10.6084/m9.figshare.30041143
title: Supplementary Material for: Deficiency of p27kip1, a cyclin-dependent kinase inhibitor, accelerates topical elastase/3-aminopropionitrile fumarate salt-induced abdominal aortic aneurysm development in mice.

description: Introduction: Abdominal aortic aneurysm (AAA) is a multifactorial disease with limited identification of contributing genetic factors. p27kip, also known as CDKN1B, is a cell cycle inhibitor that regulates vascular smooth muscle cells (VSMCs) and macrophages (Mϕ). The role of p27 in AAA development was assessed by AAA induction in p27 knockout (p27-/-) and WT mice.
Methods: AAAs were induced in male and female p27-/- and WT mice via topical elastase with oral administration of 3-aminopropionitrile fumarate salt. Aortic diameter was measured with ultrasound. VSMCs and macrophages were quantified by immunohistochemistry. Oxidative stress genes were analyzed using polymerase chain reaction. In vitro cell proliferation, migration, and oxidative stress assay were performed on VSMCs isolated from abdominal aortas.
Results: p27-/- mice developed significantly larger AAA diameter than WT mice with reduced VSMCs and increased macrophages. M1ϕ were significantly elevated in p27-/- mice, while M2ϕ were more abundant in WT mice. p27-/- mice had lower expression of the antioxidant gene, Nrf2. In vitro experiments demonstrated increased proliferation and migration in p27-/- cells with increased oxidative stress sensitivity. 
Conclusion: Knockout of p27 accelerated aneurysm growth with increased macrophage infiltration, VSMC loss, and decreased antioxidant factors, highlighting a potential role for p27 in AAA progression.
DOI: 10.6084/m9.figshare.30041143.v1
title: Supplementary Material for: Deficiency of p27kip1, a cyclin-dependent kinase inhibitor, accelerates topical elastase/3-aminopropionitrile fumarate salt-induced abdominal aortic aneurysm development in mice.

description: Introduction: Abdominal aortic aneurysm (AAA) is a multifactorial disease with limited identification of contributing genetic factors. p27kip, also known as CDKN1B, is a cell cycle inhibitor that regulates vascular smooth muscle cells (VSMCs) and macrophages (Mϕ). The role of p27 in AAA development was assessed by AAA induction in p27 knockout (p27-/-) and WT mice.
Methods: AAAs were induced in male and female p27-/- and WT mice via topical elastase with oral administration of 3-aminopropionitrile fumarate salt. Aortic diameter was measured with ultrasound. VSMCs and macrophages were quantified by immunohistochemistry. Oxidative stress genes were analyzed using polymerase chain reaction. In vitro cell proliferation, migration, and oxidative stress assay were performed on VSMCs isolated from abdominal aortas.
Results: p27-/- mice developed significantly larger AAA diameter than WT mice with reduced VSMCs and increased macrophages. M1ϕ were significantly elevated in p27-/- mice, while M2ϕ were more abundant in WT mice. p27-/- mice had lower expression of the antioxidant gene, Nrf2. In vitro experiments demonstrated increased proliferation and migration in p27-/- cells with increased oxidative stress sensitivity. 
Conclusion: Knockout of p27 accelerated aneurysm growth with increased macrophage infiltration, VSMC loss, and decreased antioxidant factors, highlighting a potential role for p27 in AAA progression.
DOI: 10.6084/m9.figshare.30041146
title: Supplementary Material for: The pace of memory decline in older adults without a neurocognitive disorder: Results from 22-years of follow-up in a nationally representative sample

description: Introduction: The pace of cognitive change is one of the major questions in cognitive aging. The Children of the Depression Age (CODA) cohort of the Health and Retirement Study (HRS) is uniquely suited to study cognitive aging because it has a long follow-up (22 years) and a narrow age range at baseline (67-74 years), and presents a unique opportunity to study this topic. 
Methods: We examined delayed recall data over the 22 years of follow-up in a nationally representative sample of the United States (HRS-CODA; N = 2,295 at baseline and N = 263 at the final follow-up wave), examining results for the entire sample and omitting participants with self-reported dementia. Data were analyzed using latent growth curve models, adjusting for baseline age, sex, years of education, and race/ethnicity. 
Results: Respondents were predominantly female (62%), White (86%), and 71 years old on average at baseline. Our results suggest the pace of normative (defined as the absence of a dementia diagnosis over the follow-up period) memory decline is about -0.05 standard deviations per year (SD/y), but is better characterized by age specific estimates of -0.04 SD/y, -0.10 SD/y, and -0.15 SD/y for an individual who was 75, 85, and 95, respectively. 
Discussion: Memory decline, in the absence of a recognized dementia and without a confounding of baseline age differences and longitudinal age changes, would be present but almost imperceptible to an individual in their eighth decade, but noticeable in their ninth and quite impairing in their tenth decade. Future research is needed to examine other cognitive domains and with more robust measures.
DOI: 10.6084/m9.figshare.30041146.v1
title: Supplementary Material for: The pace of memory decline in older adults without a neurocognitive disorder: Results from 22-years of follow-up in a nationally representative sample

description: Introduction: The pace of cognitive change is one of the major questions in cognitive aging. The Children of the Depression Age (CODA) cohort of the Health and Retirement Study (HRS) is uniquely suited to study cognitive aging because it has a long follow-up (22 years) and a narrow age range at baseline (67-74 years), and presents a unique opportunity to study this topic. 
Methods: We examined delayed recall data over the 22 years of follow-up in a nationally representative sample of the United States (HRS-CODA; N = 2,295 at baseline and N = 263 at the final follow-up wave), examining results for the entire sample and omitting participants with self-reported dementia. Data were analyzed using latent growth curve models, adjusting for baseline age, sex, years of education, and race/ethnicity. 
Results: Respondents were predominantly female (62%), White (86%), and 71 years old on average at baseline. Our results suggest the pace of normative (defined as the absence of a dementia diagnosis over the follow-up period) memory decline is about -0.05 standard deviations per year (SD/y), but is better characterized by age specific estimates of -0.04 SD/y, -0.10 SD/y, and -0.15 SD/y for an individual who was 75, 85, and 95, respectively. 
Discussion: Memory decline, in the absence of a recognized dementia and without a confounding of baseline age differences and longitudinal age changes, would be present but almost imperceptible to an individual in their eighth decade, but noticeable in their ninth and quite impairing in their tenth decade. Future research is needed to examine other cognitive domains and with more robust measures.
DOI: 10.6084/m9.figshare.30041149
title: Supplementary Material for: Prevalence and Associated Factors of Extracranial Carotid Stenosis in Northern Vietnam Patients with Transient Ischemic Attack or Ischemic Stroke

description: Background:
In Vietnam, the incidence of transient ischemic attack (TIA) or ischemic stroke has increased in recent years due to lifestyle changes. Carotid stenosis is a common cause of TIA/ischemic stroke. This study aimed to determine the prevalence and identify risk factors for ipsilateral internal carotid artery (ICA) stenosis in patients with transient ischemic attack (TIA) or ischemic stroke. 
Methods:
We recruited consecutive patients admitted to Bach Mai hospital from 06/2021 to 06/2022 with the diagnosis of TIA/ischemic stroke. The primary outcome was the presence of significant ipsilateral carotid stenosis (≥50%) by using carotid imaging modalities (duplex ultrasonography, computed tomography angiography or magnetic resonance angiography). Univariable and multivariable logistic regression analyses were performed to identify risk factors associated with 50-99% ICA stenosis.
Results:
In total, 1191 consecutive patients with TIA/ischemic stroke were included. Of these, 62 (5.2%, 95% confidence interval (CI): 4.0-6.6) had 50–99% ipsilateral ICA stenosis. Patients with significant ICA stenosis were more likely to have advanced age, male sex and prior stroke. In multivariable logistic regression, advanced age (OR 1.49 per 10-year increment; CI 95%: 1.17 -1.90, p= 0,001), male sex (OR 4.94 ; CI 95%: 2.15 – 11.38, p &lt; 0.001), and prior stroke (OR 2.01; CI 95%: 1.12 -3.62, p = 0.02) were risk factors for ICA stenosis. 
Conclusion:
The observed prevalence of extracranial ICA stenosis in TIA/ischemic stroke patients in Vietnam appears to be lower compared to Western nations, yet it is relatively comparable to that of other Asian countries. Male sex, prior stroke and advanced age constitute significant risk factors for symptomatic ICA stenosis.
DOI: 10.6084/m9.figshare.30041149.v1
title: Supplementary Material for: Prevalence and Associated Factors of Extracranial Carotid Stenosis in Northern Vietnam Patients with Transient Ischemic Attack or Ischemic Stroke

description: Background:
In Vietnam, the incidence of transient ischemic attack (TIA) or ischemic stroke has increased in recent years due to lifestyle changes. Carotid stenosis is a common cause of TIA/ischemic stroke. This study aimed to determine the prevalence and identify risk factors for ipsilateral internal carotid artery (ICA) stenosis in patients with transient ischemic attack (TIA) or ischemic stroke. 
Methods:
We recruited consecutive patients admitted to Bach Mai hospital from 06/2021 to 06/2022 with the diagnosis of TIA/ischemic stroke. The primary outcome was the presence of significant ipsilateral carotid stenosis (≥50%) by using carotid imaging modalities (duplex ultrasonography, computed tomography angiography or magnetic resonance angiography). Univariable and multivariable logistic regression analyses were performed to identify risk factors associated with 50-99% ICA stenosis.
Results:
In total, 1191 consecutive patients with TIA/ischemic stroke were included. Of these, 62 (5.2%, 95% confidence interval (CI): 4.0-6.6) had 50–99% ipsilateral ICA stenosis. Patients with significant ICA stenosis were more likely to have advanced age, male sex and prior stroke. In multivariable logistic regression, advanced age (OR 1.49 per 10-year increment; CI 95%: 1.17 -1.90, p= 0,001), male sex (OR 4.94 ; CI 95%: 2.15 – 11.38, p &lt; 0.001), and prior stroke (OR 2.01; CI 95%: 1.12 -3.62, p = 0.02) were risk factors for ICA stenosis. 
Conclusion:
The observed prevalence of extracranial ICA stenosis in TIA/ischemic stroke patients in Vietnam appears to be lower compared to Western nations, yet it is relatively comparable to that of other Asian countries. Male sex, prior stroke and advanced age constitute significant risk factors for symptomatic ICA stenosis.
DOI: 10.6084/m9.figshare.30041152
title: Supplementary Material for: Comparative Safety of Baked Egg, Egg Yolk, and Egg White in Young Children with Egg Allergy

description: Introduction: Baked egg (BE) is generally well tolerated by children with egg allergy, and heated egg yolk (EY) is considered less allergenic than egg white (EW). Although these findings suggest that both BE and EY may be safer options for reintroduction, no studies have directly compared their safety with each other or with heated EW. This study aimed to compare the safety of oral food challenge (OFC) for reintroducing BE, EY, and EW in children with egg allergy.
Methods: We retrospectively analyzed data from patients who underwent OFCs with BE, EY, or EW at the Department of Allergy, Kanagawa Children's Medical Center, between 2014 and 2024. Only patients with a history of acute IgE-mediated allergic reactions (within 2 hours of egg ingestion), an egg white-specific IgE level ≥ 0.35 UA/mL, and strict avoidance of egg protein at the time of OFC were eligible for inclusion.
Results: Ninety-seven children under three years of age were enrolled (BE group, n = 47; EY group, n = 23; EW group, n = 27). The OFC positive rate was significantly lower in the BE group (0%) compared to the EY (17.4%) and EW (22.2%) groups (P = 0.0011). Although mild skin or gastrointestinal reactions were observed in the EY group, two patients in the EW group experienced respiratory symptoms. No patient required adrenaline administration. 
Conclusion: OFC with a small amount of BE demonstrated a low positivity rate, and could be safely performed even in children with a history of egg-induced reactions.
DOI: 10.6084/m9.figshare.30041152.v1
title: Supplementary Material for: Comparative Safety of Baked Egg, Egg Yolk, and Egg White in Young Children with Egg Allergy

description: Introduction: Baked egg (BE) is generally well tolerated by children with egg allergy, and heated egg yolk (EY) is considered less allergenic than egg white (EW). Although these findings suggest that both BE and EY may be safer options for reintroduction, no studies have directly compared their safety with each other or with heated EW. This study aimed to compare the safety of oral food challenge (OFC) for reintroducing BE, EY, and EW in children with egg allergy.
Methods: We retrospectively analyzed data from patients who underwent OFCs with BE, EY, or EW at the Department of Allergy, Kanagawa Children's Medical Center, between 2014 and 2024. Only patients with a history of acute IgE-mediated allergic reactions (within 2 hours of egg ingestion), an egg white-specific IgE level ≥ 0.35 UA/mL, and strict avoidance of egg protein at the time of OFC were eligible for inclusion.
Results: Ninety-seven children under three years of age were enrolled (BE group, n = 47; EY group, n = 23; EW group, n = 27). The OFC positive rate was significantly lower in the BE group (0%) compared to the EY (17.4%) and EW (22.2%) groups (P = 0.0011). Although mild skin or gastrointestinal reactions were observed in the EY group, two patients in the EW group experienced respiratory symptoms. No patient required adrenaline administration. 
Conclusion: OFC with a small amount of BE demonstrated a low positivity rate, and could be safely performed even in children with a history of egg-induced reactions.
DOI: 10.15468/dl.8r4f5c
title: Occurrence Download

description: A dataset containing 12884 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Tephroseris palustris"
 ]
}

 The dataset includes 12884 records from 165 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021841-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29541143
title: Enzymatic responses to wetland conversion

description: Hydrolase-oxidase dichotomy underlies divergent carbon trajectories in converted wetlands: Paddy versus upland systems
DOI: 10.6084/m9.figshare.29541143.v1
title: Enzymatic responses to wetland conversion

description: Hydrolase-oxidase dichotomy underlies divergent carbon trajectories in converted wetlands: Paddy versus upland systems
DOI: 10.15468/dl.q2hqjy
title: Occurrence Download

description: A dataset containing 18 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((23.89745 26.83119,17.27338 -58.44096,147.985 -58.60747,145.98686 -12.15073,133.665 -1.66049,100.32629 2.85351,102.49094 22.83491,58.03234 37.82096,23.89745 26.83119))",
 "OccurrenceStatus is Present",
 "TaxonKey is Mesoplodon mirus"
 ]
}

 The dataset includes 18 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021844-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pucsmk
title: Occurrence Download

description: A dataset containing 675 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cakile maritima",
 "Country is Russian Federation",
 "HasCoordinate is true"
 ]
}

 The dataset includes 675 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0021848-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.