cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4929800
title: Evaluation of tree biomass carbon stock changes in Andalusian forests: comparison of two methodologies

description: Carbon sequestration has become an important issue in forest management in the light of concerns about global warming. The two methods proposed by IPCC to quantify the net carbon sequestered by trees are based either on the estimation of annual gains and losses of carbon due to the growth of trees and their removals (<i>default method</i>), or on the difference in carbon stocks between two consecutive inventories (<i>stock-change method</i>). The objectives of this study are to compare the net carbon sequestered by the tree layer of forest ecosystems in Andalusia estimated by the two methods, and to identify what measured variables contribute the most to the differences in the estimations. Multivariate analysis was performed in order to identify the causes of these variations. The results revealed differences of up to 200% in the estimated net carbon sequestration depending on the methodology employed, and changes in the direction of the capture/emission in some areas. The net carbon sequestration ranged between 0.08 ± 0.01 and 1.93 ± 0.52 Mg C ha<sup>−1</sup> year<sup>−1</sup> depending on the method used and on the tree species analyzed. In global terms, net carbon sequestration at the regional level reaches 2,101,715 ± 560,906 Mg C according to the <i>default method</i> and 1,693,412 ± 272,529 Mg C using the <i>stock-change method</i>.
DOI: 10.6084/m9.figshare.4929800.v1
title: Evaluation of tree biomass carbon stock changes in Andalusian forests: comparison of two methodologies

description: Carbon sequestration has become an important issue in forest management in the light of concerns about global warming. The two methods proposed by IPCC to quantify the net carbon sequestered by trees are based either on the estimation of annual gains and losses of carbon due to the growth of trees and their removals (<i>default method</i>), or on the difference in carbon stocks between two consecutive inventories (<i>stock-change method</i>). The objectives of this study are to compare the net carbon sequestered by the tree layer of forest ecosystems in Andalusia estimated by the two methods, and to identify what measured variables contribute the most to the differences in the estimations. Multivariate analysis was performed in order to identify the causes of these variations. The results revealed differences of up to 200% in the estimated net carbon sequestration depending on the methodology employed, and changes in the direction of the capture/emission in some areas. The net carbon sequestration ranged between 0.08 ± 0.01 and 1.93 ± 0.52 Mg C ha<sup>−1</sup> year<sup>−1</sup> depending on the method used and on the tree species analyzed. In global terms, net carbon sequestration at the regional level reaches 2,101,715 ± 560,906 Mg C according to the <i>default method</i> and 1,693,412 ± 272,529 Mg C using the <i>stock-change method</i>.
DOI: 10.6084/m9.figshare.4929773
title: Supplementary Material for: Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> A sex-related switch in the prevalence of asthma from childhood (male predominance) to adulthood (female predominance) has been described, but for allergic rhinitis this remains unclear. We aimed to examine sex- and age-group-specific differences in allergic rhinitis prevalence by systematically evaluating studies from across the globe. <b><i>Methods:</i></b> A systematic search of MEDLINE and Embase for population-based cross-sectional studies was performed regardless of the language of publication. The search was restricted to the present millennium (2000 to June 2014). Study quality was defined by the sampling method, response rate, sample size, and data collection method. To assess sex differences in the prevalence of self- or parent-reported symptoms of rhinitis, calculated pooled estimates of the male-female ratio (MFR) were obtained using random-effects model meta-analyses due to heterogeneity. A meta-regression analysis was also performed. <b><i>Results:</i></b> Out of 6,539 publications identified, 67 cross-sectional population-based studies (291,726 males and 301,781 females) were included in our meta-analysis. In children (&lt;11 years of age) significantly more boys than girls had rhinitis symptoms (MFR 1.21, 95% CI 1.17-1.25), whereas in adolescents (11 to &lt;18 years of age) males were significantly less often affected than females (MFR 0.90, 95% CI 0.85-0.95). No sex-specific prevalence difference was observed in adults (MFR 0.96, 95% CI 0.83-1.17). These findings were consistent in all continents except in Asia, where the male predominance remained beyond childhood. <b><i>Conclusions:</i></b> The male predominance of rhinitis prevalence in childhood changed towards a female predominance in adolescence across the globe, except in Asia. Longitudinal studies are needed to confirm these cross-sectional data and examine possible determinants and underlying mechanisms.
DOI: 10.6084/m9.figshare.4929773.v1
title: Supplementary Material for: Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

description: <b><i>Background:</i></b> A sex-related switch in the prevalence of asthma from childhood (male predominance) to adulthood (female predominance) has been described, but for allergic rhinitis this remains unclear. We aimed to examine sex- and age-group-specific differences in allergic rhinitis prevalence by systematically evaluating studies from across the globe. <b><i>Methods:</i></b> A systematic search of MEDLINE and Embase for population-based cross-sectional studies was performed regardless of the language of publication. The search was restricted to the present millennium (2000 to June 2014). Study quality was defined by the sampling method, response rate, sample size, and data collection method. To assess sex differences in the prevalence of self- or parent-reported symptoms of rhinitis, calculated pooled estimates of the male-female ratio (MFR) were obtained using random-effects model meta-analyses due to heterogeneity. A meta-regression analysis was also performed. <b><i>Results:</i></b> Out of 6,539 publications identified, 67 cross-sectional population-based studies (291,726 males and 301,781 females) were included in our meta-analysis. In children (&lt;11 years of age) significantly more boys than girls had rhinitis symptoms (MFR 1.21, 95% CI 1.17-1.25), whereas in adolescents (11 to &lt;18 years of age) males were significantly less often affected than females (MFR 0.90, 95% CI 0.85-0.95). No sex-specific prevalence difference was observed in adults (MFR 0.96, 95% CI 0.83-1.17). These findings were consistent in all continents except in Asia, where the male predominance remained beyond childhood. <b><i>Conclusions:</i></b> The male predominance of rhinitis prevalence in childhood changed towards a female predominance in adolescence across the globe, except in Asia. Longitudinal studies are needed to confirm these cross-sectional data and examine possible determinants and underlying mechanisms.
DOI: 10.6084/m9.figshare.4929728
title: Supplementary Material for: Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy

description: <b><i>Background:</i></b> Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively. The immuno-solid phase allergen chip (ISAC) enables testing for specific IgE against multiple allergen components in a multiplex assay. <b><i>Methods:</i></b> We retrospectively analysed clinic letters, case notes, and laboratory results of 118 patients attending the National Adult Allergy Service at the University Hospital of Wales who presented diagnostic difficulty, to evaluate which testing strategy (SPT, ImmunoCAP, or ISAC) was the most appropriate to use to confirm the diagnosis in these complex patients, evaluated in a “real-life” clinical service setting. <b><i>Results:</i></b> In patients with nut allergy, the detection rates of SPTs (56%) and ISAC (65%) were lower than those of ImmunoCAP (71%). ISAC had a higher detection rate (88%) than ImmunoCAP (69%) or SPT (33%) in the diagnosis of oral allergy syndrome. ImmunoCAP test results identified all 9 patients with anaphylaxis due to wheat allergy (100%), whereas ISAC was positive in only 6 of these 9 (67%). <b><i>Conclusions:</i></b> In this difficult diagnostic group, the ImmunoCAP test should be the preferred single test for possible allergy to nuts, wheat, other specific foods, and anaphylaxis of any cause. In these conditions, SPT and ISAC tests give comparable results. The most useful single test for oral allergy syndrome is ISAC, and SPT should be the preferred test for latex allergy.
DOI: 10.6084/m9.figshare.4929728.v1
title: Supplementary Material for: Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy

description: <b><i>Background:</i></b> Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively. The immuno-solid phase allergen chip (ISAC) enables testing for specific IgE against multiple allergen components in a multiplex assay. <b><i>Methods:</i></b> We retrospectively analysed clinic letters, case notes, and laboratory results of 118 patients attending the National Adult Allergy Service at the University Hospital of Wales who presented diagnostic difficulty, to evaluate which testing strategy (SPT, ImmunoCAP, or ISAC) was the most appropriate to use to confirm the diagnosis in these complex patients, evaluated in a “real-life” clinical service setting. <b><i>Results:</i></b> In patients with nut allergy, the detection rates of SPTs (56%) and ISAC (65%) were lower than those of ImmunoCAP (71%). ISAC had a higher detection rate (88%) than ImmunoCAP (69%) or SPT (33%) in the diagnosis of oral allergy syndrome. ImmunoCAP test results identified all 9 patients with anaphylaxis due to wheat allergy (100%), whereas ISAC was positive in only 6 of these 9 (67%). <b><i>Conclusions:</i></b> In this difficult diagnostic group, the ImmunoCAP test should be the preferred single test for possible allergy to nuts, wheat, other specific foods, and anaphylaxis of any cause. In these conditions, SPT and ISAC tests give comparable results. The most useful single test for oral allergy syndrome is ISAC, and SPT should be the preferred test for latex allergy.
DOI: 10.6084/m9.figshare.4929644
title: The challenges of participatory and systemic environmental management: from aspiration to implementation

description: Participatory and systemic approaches in environmental management are advocated as they are thought to lead to more equitable, resilient and integrated solutions. However, there is mounting evidence that, in practice, these approaches are exceedingly challenging and do not always lead to improved environmental management, or greater community engagement. To better understand the challenges facing organisations wishing to use these approaches, we monitored the dynamics of a decision-making process on an estate. We observed an oscillating pattern of widening and narrowing participation and integration. Three key factors created tensions with the estate's desires to increase community participation and follow a more systemic approach: stewardship values, organisational capacity and unresolved core issues. A combination of these tensions and other factors led to the early cessation of a series of planned participatory workshops. We conclude that academia needs to take these challenges seriously by placing greater emphasis on multi-dimensional, transdisciplinary analysis of such transformation processes.
DOI: 10.6084/m9.figshare.4929638
title: Differential expression in obese vs non-obese adipocyte progenitors - nominal significance.

description: Comparison of gene expression in adipocyte progenitors from non-obese (n=10) and obese (n=9). Microarray data was RMA normalized, filtered so only probes with an associated gene symbols were kept, and then analyzed in limma to identify differentially expresssed genes. No significant genes were found after correction for multiple hypothesis testing. Genes were then filtered on nominal significance (uncorrected p-value &lt; 0.05) and log fold change &gt; |0.585|.
DOI: 10.6084/m9.figshare.4929632
title: Cost-utility of biological treatment sequences for luminal Crohn’s disease in Europe

description: <b>Background</b>: This study aims to compare the cost-effectiveness of treatment sequences with available biologics, including adalimumab (ADA), biosimilar infliximab (bsIFX), originator infliximab (IFX) and vedolizumab (VEDO) for luminal Crohn’s disease in nine European countries. <b>Methods</b>: A Markov-model was constructed to simulate five-year medical costs and quality-adjusted life years (QALYs). Data on clinical efficacy were obtained from randomised controlled trials. Country-specific unit costs, discount rates and a third-party payer perspective were applied. <b>Results</b>: The bsIFX versus conventional therapy resulted in the most favourable incremental cost-utility ratios (ICURs) ranging from €34,580 (Hungary) to €77,062/QALY (Sweden). Compared to bsIFX, the bsIFX-ADA sequence was more cost-effective than the bsIFX-VEDO sequence with ICURs varying between €70,277 (France) and €162,069/QALY (Germany). The ICURs of the bsIFX-ADA-VEDO sequence versus the bsIFX-ADA strategy were between €206,266 (The Netherlands) and €363,232/QALY (Spain). <b>Conclusion</b>: We are the first to compare cost-effectiveness of multiple biological sequences for luminal Crohn’s disease. Based on our findings, bsIFX can be recommended as a first-line treatment in patients unresponsive to conventional treatments. While biological sequences only slightly differ in their associated health gains, their costs vary greatly. The bsIFX-ADA-VEDO seems to be the most cost-effective sequence of the available biologics across Europe.
DOI: 10.6084/m9.figshare.4929638.v1
title: Differential expression in obese vs non-obese adipocyte progenitors - nominal significance.

description: Comparison of gene expression in adipocyte progenitors from non-obese (n=10) and obese (n=9). Microarray data was RMA normalized, filtered so only probes with an associated gene symbols were kept, and then analyzed in limma to identify differentially expresssed genes. No significant genes were found after correction for multiple hypothesis testing. Genes were then filtered on nominal significance (uncorrected p-value &lt; 0.05) and log fold change &gt; |0.585|.
DOI: 10.6084/m9.figshare.4929644.v1
title: The challenges of participatory and systemic environmental management: from aspiration to implementation

description: Participatory and systemic approaches in environmental management are advocated as they are thought to lead to more equitable, resilient and integrated solutions. However, there is mounting evidence that, in practice, these approaches are exceedingly challenging and do not always lead to improved environmental management, or greater community engagement. To better understand the challenges facing organisations wishing to use these approaches, we monitored the dynamics of a decision-making process on an estate. We observed an oscillating pattern of widening and narrowing participation and integration. Three key factors created tensions with the estate's desires to increase community participation and follow a more systemic approach: stewardship values, organisational capacity and unresolved core issues. A combination of these tensions and other factors led to the early cessation of a series of planned participatory workshops. We conclude that academia needs to take these challenges seriously by placing greater emphasis on multi-dimensional, transdisciplinary analysis of such transformation processes.
DOI: 10.6084/m9.figshare.4929632.v1
title: Cost-utility of biological treatment sequences for luminal Crohn’s disease in Europe

description: <b>Background</b>: This study aims to compare the cost-effectiveness of treatment sequences with available biologics, including adalimumab (ADA), biosimilar infliximab (bsIFX), originator infliximab (IFX) and vedolizumab (VEDO) for luminal Crohn’s disease in nine European countries. <b>Methods</b>: A Markov-model was constructed to simulate five-year medical costs and quality-adjusted life years (QALYs). Data on clinical efficacy were obtained from randomised controlled trials. Country-specific unit costs, discount rates and a third-party payer perspective were applied. <b>Results</b>: The bsIFX versus conventional therapy resulted in the most favourable incremental cost-utility ratios (ICURs) ranging from €34,580 (Hungary) to €77,062/QALY (Sweden). Compared to bsIFX, the bsIFX-ADA sequence was more cost-effective than the bsIFX-VEDO sequence with ICURs varying between €70,277 (France) and €162,069/QALY (Germany). The ICURs of the bsIFX-ADA-VEDO sequence versus the bsIFX-ADA strategy were between €206,266 (The Netherlands) and €363,232/QALY (Spain). <b>Conclusion</b>: We are the first to compare cost-effectiveness of multiple biological sequences for luminal Crohn’s disease. Based on our findings, bsIFX can be recommended as a first-line treatment in patients unresponsive to conventional treatments. While biological sequences only slightly differ in their associated health gains, their costs vary greatly. The bsIFX-ADA-VEDO seems to be the most cost-effective sequence of the available biologics across Europe.
DOI: 10.6084/m9.figshare.4929572
title: The Influence of Endogenous and Exogenous Spatial Attention on Decision Confidence

description: This dataset contains behavioral data in 28 matlab files corresponding to 28 subjects that performed a psychophysics task to asses the influence of endogenous and exogenous attention on decision confidence. <br><br>In addition, the eye position during the task was recorded from subject 8 onward and is stored in the _eye.mat files in the data format of the Fieldtrip Toolbox (http://www.fieldtriptoolbox.org/reference/ft_datatype_raw). <br>Information about each trial is stored in the <i>trialinfo</i> matrix of the data with the columns being <br>(1) trial number, (2), condition, (3) trial outcome, (4) stimulus position, (5) stimulus spatial frequency, (6) stimulus contrast, (7) stimulus diameter (8) stimulus onset time, (9) response onset time, (10) confidence rating onset time, (11) accuracy (12) rated confidence.<br>
DOI: 10.6084/m9.figshare.4929572.v1
title: The Influence of Endogenous and Exogenous Spatial Attention on Decision Confidence

description: This dataset contains behavioral data in 28 matlab files corresponding to 28 subjects that performed a psychophysics task to asses the influence of endogenous and exogenous attention on decision confidence. <br><br>In addition, the eye position during the task was recorded from subject 8 onward and is stored in the _eye.mat files in the data format of the Fieldtrip Toolbox (http://www.fieldtriptoolbox.org/reference/ft_datatype_raw). <br>Information about each trial is stored in the <i>trialinfo</i> matrix of the data with the columns being <br>(1) trial number, (2), condition, (3) trial outcome, (4) stimulus position, (5) stimulus spatial frequency, (6) stimulus contrast, (7) stimulus diameter (8) stimulus onset time, (9) response onset time, (10) confidence rating onset time, (11) accuracy (12) rated confidence.<br>
DOI: 10.6084/m9.figshare.4929530
title: Supplementary Material for: Purification and Biochemical and Kinetic Properties of an Endo-Polygalacturonase from the Industrial Fungus Aspergillus sojae

description: An endo-polygalacturonase secreted by <i>Aspergillus sojae </i>was characterized after being purified to homogeneity from submerged cultures with orange peel as the sole carbon source by gel filtration and ion-exchange chromatographies. According to SDS-PAGE and analytical isoelectric focusing analyses, the enzyme presents a molecular weight of 47 kDa and pI value of 4.2. This enzyme exhibits considerable stability under highly acidic to neutral conditions (pH 1.5-6.5) and presents a half-life of 2 h at 50°C. Besides its activity towards pectin and polygalacturonic acid, the enzyme displays pectin-releasing activity, acting best in a pH range of 3.3-5.0. Thin-layer chromatographic analysis revealed that tri-galacturonate is the main enzymatic end product of polygalacturonic acid hydrolysis, indicating that it is an endo-polygalacturonase. The enzyme exhibits Michaelis-Menten kinetics, with K<sub>M</sub> and V<sub>MAX</sub> values of 0.134 mg/mL and 9.6 µmol/mg/min, respectively, and remained stable and active in the presence of SO<sub>2</sub>, ethanol, and various cations assayed except Hg<sup>2+</sup>.
DOI: 10.6084/m9.figshare.4929533
title: Supplementary Material for: Changing Epidemiological Patterns in Traumatic Brain Injury: A Longitudinal Hospital-Based Study in Belgium

description: <b><i>Background:</i></b> Various reports have suggested that epidemiological patterns of Traumatic Brain Injury (TBI) are changing in high-income countries, but the evidence to support this is often indirect and only a few longitudinal studies exist. We aimed to explore epidemiological patterns of TBI in Belgium over a 10-year period. <b><i>Methods:</i></b> A retrospective analysis of Minimum Hospital Data provided by Statistics Belgium was performed for the period 2003-2012. ICD-9 classification was used to identify TBI and to differentiate subtypes. The annual incidence of hospital admissions and in-hospital mortality rates were calculated and further differentiated for age, gender and cause of injury. <b><i>Results:</i></b> The age-adjusted incidence of hospital admissions decreased by 3.6% per year. An increase in the number of elderly patients with TBI and a decrease in the younger age groups were found. Falls now represent the main cause of TBI. A mortality rate of 6.5 per 100,000 population per year was found and did not change significantly over time. <b><i>Conclusions:</i></b> This longitudinal study confirms that epidemiological patterns in TBI are changing: overall incidence is steadily decreasing, but in elderly patients, the incidence is increasing. Falls are the leading cause, occurring most frequently in elderly patients. These changes are relevant for prevention.