cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19962744.v1
title: Identification and relationship of quality of life and self-care ability among Chinese patients with traumatic spinal cord injuries: a cross-sectional analysis

description: Improving the quality of life of patients with complete spinal cord injuries is an urgent objective of the Chinese Department of Health. For better management of spinal cord injuries, it is necessary to understand the background of the patients. A total of 392 patients aged ≥18 years with traumatic spinal cord injuries (≥1 year of history) were attending the rehabilitation center of the Institutes. A total of 7 (2%) patients reported low quality of life, 200 (51%) patients reported moderate quality of life, 181 (46%) patients reported good quality of life, and 4 (1%) patients reported excellent quality of life. Male patients (P=0.042), patients with college or more education (P=0.039), incomplete spinal cord injuries (P=0.045), paraplegia (P=0.046), and absence of pressure injury (P=0.047) were associated with higher quality of life. A total of 81 (21%) patients were dependent on the caregiver, 85 (22%) patients were highly dependent on the caregiver, 155 (40%) patients were moderately dependent on the caregiver, 60 (15%) patients were mildly dependent on the caregiver, and 11 (2%) patients were independent for activities of daily living. An incomplete spinal cord injury (P=0.045) and paraplegia (P=0.041) were associated with higher independence in activities of daily living of patients. The independence in activities of daily living and quality of life of the Chinese population with complete spinal cord injury and tetraplegia are poor (Level of Evidence: IV; Technical Efficacy Stage: 5).
DOI: 10.6084/m9.figshare.19962633
title: Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model

description: The objective was to study the effect of mechanical intestinal obstruction in rats on the phenotype of interstitial cells of Cajal (ICC). Healthy Wistar rats were randomly divided into sham-operation group (C), one day obstruction group (M1), two days obstruction group (M2), and three days obstruction group (M3), with 10 rats in each group. The expression of SCF mRNA and c-Kit protein in intestinal tissue was investigated by RT-PCR and immunohistochemistry. Compared with the sham-operation group, the relative expression of SCF mRNA and the expression of c-Kit protein in intestinal tissue were significantly decreased in both obstruction groups. Levels decreased gradually with the prolongation of obstruction time, and significantly decreased on the 3rd day after obstruction (P&lt;0.05). Immunohistochemical staining of the small intestine showed that the number of ICC in the sham-operation group was the highest, and they were gradually decreased with the extension of obstruction time in the M1 to M3 groups. There was a significant difference between groups (P&lt;0.05). Intestinal obstruction caused a decrease in the concentrations of SCF mRNA and c-Kit protein in ICC. With the prolongation of intestinal obstruction, the number of ICCs gradually decreased.
DOI: 10.6084/m9.figshare.19962633.v1
title: Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model

description: The objective was to study the effect of mechanical intestinal obstruction in rats on the phenotype of interstitial cells of Cajal (ICC). Healthy Wistar rats were randomly divided into sham-operation group (C), one day obstruction group (M1), two days obstruction group (M2), and three days obstruction group (M3), with 10 rats in each group. The expression of SCF mRNA and c-Kit protein in intestinal tissue was investigated by RT-PCR and immunohistochemistry. Compared with the sham-operation group, the relative expression of SCF mRNA and the expression of c-Kit protein in intestinal tissue were significantly decreased in both obstruction groups. Levels decreased gradually with the prolongation of obstruction time, and significantly decreased on the 3rd day after obstruction (P&lt;0.05). Immunohistochemical staining of the small intestine showed that the number of ICC in the sham-operation group was the highest, and they were gradually decreased with the extension of obstruction time in the M1 to M3 groups. There was a significant difference between groups (P&lt;0.05). Intestinal obstruction caused a decrease in the concentrations of SCF mRNA and c-Kit protein in ICC. With the prolongation of intestinal obstruction, the number of ICCs gradually decreased.
DOI: 10.6084/m9.figshare.19962639.v1
title: miR-183 promotes radioresistance of lung adenocarcinoma H1299 cells via epithelial-mesenchymal transition

description: Lung adenocarcinomas are usually sensitive to radiation therapy, but some develop resistance. Radiation resistance can lead to poor patient prognosis. Studies have shown that lung adenocarcinoma cells (H1299 cells) can develop radioresistance through epithelial-mesenchymal transition (EMT), and this process is regulated by miRNAs. However, it is unclear which miRNAs are involved in the process of EMT. In our present study, we found that miR-183 expression was increased in a radioresistant lung adenocarcinoma cell line (H1299R cells). We then explored the regulatory mechanism of miR-183 and found that it may be involved in the regulation of zinc finger E-box-binding homeobox 1 (ZEB1) expression and mediate EMT in lung adenocarcinoma cells. qPCR results showed that miR-183, ZEB1, and vimentin were highly expressed in H1299R cells, whereas no difference was observed in E-cadherin expression. Western blot results showed that ZEB1 and vimentin were highly expressed in H1299R cells, while E-cadherin expression was decreased. When miR-183 expression was inhibited in H1299R cells, radiation resistance, proliferation, and cell migration were decreased. The expression of ZEB1 and vimentin in H1299R cells was decreased, while the expression of E-cadherin was increased. Moreover, miR-183 overexpression in H1299 cells enhanced radiation resistance, proliferative capacity, and cell migration ability. The expression of ZEB1 and vimentin in H1299 cells was increased, while that of E-cadherin was decreased. In conclusion, miR-183 may promote EMT and radioresistance in H1299 cells, and targeting the miR-183-ZEB1 signaling pathway may be a promising approach for lung cancer treatment.
DOI: 10.6084/m9.figshare.13669534.v1
title: Additional file 1 of Degradome sequencing-based identification of phasiRNAs biogenesis pathways in Oryza sativa

description: Additional file 1: Table S1. Identification of 21-nt PHAS loci in Rice
DOI: 10.6084/m9.figshare.13669546
title: Additional file 5 of Degradome sequencing-based identification of phasiRNAs biogenesis pathways in Oryza sativa

description: Additional file 5: Table S3. Datasets utilized for our study.
DOI: 10.6084/m9.figshare.19962639
title: miR-183 promotes radioresistance of lung adenocarcinoma H1299 cells via epithelial-mesenchymal transition

description: Lung adenocarcinomas are usually sensitive to radiation therapy, but some develop resistance. Radiation resistance can lead to poor patient prognosis. Studies have shown that lung adenocarcinoma cells (H1299 cells) can develop radioresistance through epithelial-mesenchymal transition (EMT), and this process is regulated by miRNAs. However, it is unclear which miRNAs are involved in the process of EMT. In our present study, we found that miR-183 expression was increased in a radioresistant lung adenocarcinoma cell line (H1299R cells). We then explored the regulatory mechanism of miR-183 and found that it may be involved in the regulation of zinc finger E-box-binding homeobox 1 (ZEB1) expression and mediate EMT in lung adenocarcinoma cells. qPCR results showed that miR-183, ZEB1, and vimentin were highly expressed in H1299R cells, whereas no difference was observed in E-cadherin expression. Western blot results showed that ZEB1 and vimentin were highly expressed in H1299R cells, while E-cadherin expression was decreased. When miR-183 expression was inhibited in H1299R cells, radiation resistance, proliferation, and cell migration were decreased. The expression of ZEB1 and vimentin in H1299R cells was decreased, while the expression of E-cadherin was increased. Moreover, miR-183 overexpression in H1299 cells enhanced radiation resistance, proliferative capacity, and cell migration ability. The expression of ZEB1 and vimentin in H1299 cells was increased, while that of E-cadherin was decreased. In conclusion, miR-183 may promote EMT and radioresistance in H1299 cells, and targeting the miR-183-ZEB1 signaling pathway may be a promising approach for lung cancer treatment.
DOI: 10.6084/m9.figshare.19962816.v1
title: The LDL/HDL ratio predicts long-term risk of coronary revascularization in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: a cohort study

description: Clinical indicators do not adequately predict the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio is expected to be a reliable predictor of the long-term prognosis of these patients. This study aimed to explore the correlation between the LDL/HDL ratio and long-term prognosis in STEMI patients undergoing PCI. Patients with confirmed STEMI who underwent PCI in 7 hospitals in China from January 2009 to December 2011 were enrolled. Information about clinical endpoints, including all-cause death and major adverse cardiovascular events, was collected. Overall, 915 patients were included for analysis, the average follow-up time was 112.2 months. According to the LDL/HDL ratio, the patients were divided into 3 groups using the three-quantile method: low (LDL/HDL≤1.963), medium (1.963
DOI: 10.21954/ou.rd.25134101
title: DEPA – Ethiopia PhotoVoice Images Representing Gender-Based Violence

description: This collection contains 170 photographs that were taken by the 12 youth participants involved in the PhotoVoice aspect of the research methodology. The images are representations of how the youth view, understand and experience gender-based violence in their community. For anonymity and security, participants were asked to only take images of objects and places, and not human subjects.The associated README file holds the metadata for each of the 170 individual data files. The information is organised sequentially by file number and provides the: file name, data type, a title and a description. The file names can be used to cross reference to get more detail on a particular file.The Ethiopia Project is a commissioned project with DEPA (Decolonising Education for Peace in Africa). DEPA was a 4 year project funded by the Arts and Humanities Council (AHRC) addressing the question: What are the different knowledges and values underpinning peace and how can these practices be connected and compared across countries to create curriculum content and mode of delivery in informal and formal settings, Secondary and Higher Education (HE), in order to decolonise peace education?
DOI: 10.21954/ou.rd.25134101.v2
title: DEPA – Ethiopia PhotoVoice Images Representing Gender-Based Violence

description: This collection contains 170 photographs that were taken by the 12 youth participants involved in the PhotoVoice aspect of the research methodology. The images are representations of how the youth view, understand and experience gender-based violence in their community. For anonymity and security, participants were asked to only take images of objects and places, and not human subjects.The associated README file holds the metadata for each of the 170 individual data files. The information is organised sequentially by file number and provides the: file name, data type, a title and a description. The file names can be used to cross reference to get more detail on a particular file.The Ethiopia Project is a commissioned project with DEPA (Decolonising Education for Peace in Africa). DEPA was a 4 year project funded by the Arts and Humanities Council (AHRC) addressing the question: What are the different knowledges and values underpinning peace and how can these practices be connected and compared across countries to create curriculum content and mode of delivery in informal and formal settings, Secondary and Higher Education (HE), in order to decolonise peace education?
DOI: 10.21954/ou.rd.25134101.v1
title: DEPA – Ethiopia PhotoVoice Images Representing Gender-Based Violence

description: This collection contains 170 photographs that were taken by the 12 youth participants involved in the PhotoVoice aspect of the research methodology. The images are representations of how the youth view, understand and experience gender-based violence in their community. For anonymity and security, participants were asked to only take images of objects and places, and not human subjects.  The Ethiopia Project is a commissioned project with DEPA (Decolonising Education for Peace in Africa). DEPA was a 4 year project funded by the Arts and Humanities Council (AHRC) addressing the question: What are the different knowledges and values underpinning peace and how can these practices be connected and compared across countries to create curriculum content and mode of delivery in informal and formal settings, Secondary and Higher Education (HE), in order to decolonise peace education?
DOI: 10.6084/m9.figshare.11578020
title: MOESM2 of Proteomic analysis reflects an environmental alkalinization-coupled pH-dependent mechanism of regulating lignocellulases in Trichoderma guizhouense NJAU4742

description: Additional file 2. The identification and quantification results of all the proteins from different treatments.
DOI: 10.6084/m9.figshare.11578026
title: MOESM3 of Proteomic analysis reflects an environmental alkalinization-coupled pH-dependent mechanism of regulating lignocellulases in Trichoderma guizhouense NJAU4742

description: Additional file 3. The raw data for the Cytoscape interaction network analysis.
DOI: 10.6084/m9.figshare.11578026.v1
title: MOESM3 of Proteomic analysis reflects an environmental alkalinization-coupled pH-dependent mechanism of regulating lignocellulases in Trichoderma guizhouense NJAU4742

description: Additional file 3. The raw data for the Cytoscape interaction network analysis.
DOI: 10.6084/m9.figshare.8956637.v2
title: TAp73 expression and P1 promoter methylation, a potential marker for chemoresponsiveness to cisplatin therapy and survival in muscle-invasive bladder cancer (MIBC)

description: Intrinsic and/or acquired resistance to cisplatin is a significant obstacle in the treatment of muscle-invasive bladder cancer. p73, a p53 homolog and determinant of chemosensitivity, is rarely mutated in bladder cancer (BC). However p73 expression and therefore function can be repressed through epigenetic changes. In this study, we sought to identify DNA methylation status of p73, expression of TAp73 isoform, and their role in cisplatin sensitivity in BC. Primary tumor samples from 338 bladder cancer patients showed decreased TAp73 expression in MIBC compared to superficial BC. Low TAp73 protein expression was associated with shorter overall survival. To investigate if the loss of expression was methylation dependent, we utilized Illumina 450K methylation arrays to interrogate over 150 BC patient samples. We found 12 distinct CpGs in the p73 gene locus that were hypermethylated in tumors compared to adjacent normal tissues. Patients with high p73 promoter methylation specifically at CpG site cg07382920 had worse survival. <i>In vitro</i>, treatment with a DNA demethylating agent, decitabine (DAC), decreased TAp73 methylation and upregulated expression in both CR-T24 (cisplatin resistant T24 cells) and wild type T24 cells. Furthermore, treatment with DAC increased cisplatin response in wild type T24 and CR-T24. Our studies indicate that TAp73 expression and P1 promoter methylation, specifically at the cg073892920 site, may have prognostic and diagnostic value in MIBC. In the setting of P1 promoter hypermethylation, DAC could be used as a potentiating agent of cisplatin-based chemotherapy.
DOI: 10.6084/m9.figshare.14199520
title: Estimation and Inference for Multi-Kink Quantile Regression

description: This article proposes a new Multi-Kink Quantile Regression (MKQR) model which assumes different linear quantile regression forms in different regions of the domain of the threshold covariate but are still continuous at kink points. First, we investigate parameter estimation, kink points detection and statistical inference in MKQR models. We propose an iterative segmented quantile regression algorithm for estimating both the regression coefficients and the locations of kink points. The proposed algorithm is much more computationally efficient than the grid search algorithm and not sensitive to the selection of initial values. Second, asymptotic properties, such as selection consistency of the number of kink points and asymptotic normality of the estimators of both regression coefficients and kink effects, are established to justify the proposed method theoretically. Third, a score test based on partial subgradients is developed to verify whether the kink effects exist or not. Test-inversion confidence intervals for kink location parameters are also constructed. Monte Carlo simulations and two real data applications on the secondary industrial structure of China and the triceps skinfold thickness of Gambian females illustrate the excellent finite sample performances of the proposed MKQR model. A new R package <i>MultiKink</i> is developed to easily implement the proposed methods.
DOI: 10.5255/ukda-sn-856861
title: Experimental Data for Psychological Research: Investigating Effect of Processing Spatial Information on Perception of Time and Intertemporal Preferences, 2021

description: Our mental representation of the passage of time is structured by concepts of spatial motion, including an ego-moving perspective in which the self is perceived as approaching future events, and a time-moving perspective in which future events are perceived as approaching the self. Previous research has found that processing spatial information in one’s environment can preferentially activate either an ego-moving or time-moving temporal perspective, but potential downstream effects on decision-making have received less empirical attention. Based on the idea that people may feel closer to positively valenced events they conceptualise themselves as actively approaching rather than passively waiting for, in this pre-registered study we tested the hypothesis that spatial primes corresponding to an ego-moving (vs. time-moving) perspective would attenuate temporal discounting by making future rewards feel more proximal. 599 participants were randomly assigned to one of three spatial prime conditions (ego-moving, time-moving, control) resembling map-based tasks people may engage with on digital devices, and then completed measures of temporal perspective, perceived wait time, perceived control, and temporal discounting. Partly consistent with previous research, the results indicated that the time-moving condition successfully primed the intended temporal perspective though the ego-moving condition did not. Contrary to our primary hypotheses, the spatial primes had no effect on either perceived wait time or temporal discounting. Processing spatial information in a map-based task therefore appears to influence how people conceptualise the passage of time, but there was no evidence for downstream effects on intertemporal preferences. Exploratory analysis indicated that greater perceived control was associated with lower temporal discounting, mediated by a reduction in perceived wait time, suggesting a possible area for future research into individual differences and interventions in intertemporal decision-making.
DOI: 10.6084/m9.figshare.19962742
title: CircRNA has_circ_0001806 promotes hepatocellular carcinoma progression via the miR-193a-5p/MMP16 pathway

description: Reportedly, circular RNAs (circRNAs) are crucial regulators in cancer progression. Nonetheless, the molecular mechanism of circRNAs in hepatocellular carcinoma (HCC) has not been fully clarified. Gene expression omnibus (GEO) database was employed to screen out the differentially expressed circRNAs in HCC. qRT-PCR and western blot were executed to detect circ_0001806 expression, miR-193a-5p expression, and MMP16 mRNA and protein expressions in HCC. The effect of circ_0001806 on HCC was analyzed by the CCK-8 method and Transwell experiment. RIP assay, pull-down experiment, and dual-luciferase reporter gene experiment were applied to validate the targeting relationships among circ_0001806, miR-193a-5p, and MMP16. Circ_0001806 was up-modulated in HCC tissues and cell lines. Knockdown of circ_0001806 impeded the multiplication, migration, and invasion of HCC cells. Circ_0001806 could up-regulate MMP16 expression through repressing miR-193a-5p, thereby facilitating the malignant biological behaviors of HCC. Circ_0001806 promoted HCC progression by regulating miR-193a-5p/MMP16 axis.
DOI: 10.6084/m9.figshare.24161046
title: <b>Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats</b><b>with pre-diabetes</b>

description: Model rats showed significant glucose intolerance, elevated lipids and insulin resistance. After treatment with berberine, their conditions were improved, i.e., Berberinereduced glucose intolerance, lowered lipids and restored insulin sensitivity. In addition, oxidative stress and apoptosis levels were significantly increased in the hippocampus of pre-diabetic rats. The Model rats exhibited much lower Bcl2 levels and higher Bax levels. However, the administration of berberineeffectively decreased the levels of oxidative stress and apoptosis in the hippocampus of pre-diabetic rats.
DOI: 10.6084/m9.figshare.19962784
title: Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function

description: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly. The aim of this study was to explore the effects of AD on cardiac function and autonomic nervous function, and the feasibility of electrocardiogram (ECG) in monitoring the development of AD. APP/PS1 double transgenic mice were used in the Morris water maze (MWM) experiment to evaluate the changes of cognitive ability of AD mice, then the non-invasive ECG acquisition system was used and the changes of ECG intervals and heart rate variability (HRV) were analyzed. AD mice already had cognitive dysfunction at the age of 5 months, reaching the level of mild dementia, and the degree of dementia increased with the course of disease. There were no significant changes in ECG intervals in the AD group at each month. The mean square of successive RR interval differences, percentage of intervals &gt;6 ms different from preceding interval, and normalized high frequency power component in the AD group were decreased and low-to-high frequency power ratio and normalized low frequency power component were increased. Combined with the results of the MWM, it was shown that the regulation mechanism of sympathetic and parasympathetic nerves in mice was already imbalanced in early stage AD, which was manifested as the increase of excessive activity of sympathetic nerves and the inhibition of parasympathetic activities. Therefore, ECG-based analysis of HRV may become a means of daily monitoring of AD and provide an auxiliary basis for clinical diagnosis.
DOI: 10.6084/m9.figshare.23632656
title: Additional file 2 of Growth hormone treatment improves the development of follicles and oocytes in prepubertal lambs

description: Additional file 2. DEPs in ovarian proteome between control and GH treatment groups.