cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26519824.v1
title: Supplementary Material for: High expression of cancer-derived sialylated immunoglobulin G: a novel biomarker for poor prognosis in laryngeal squamous cell carcinoma

description: Introduction: Laryngeal squamous cell carcinoma (LSCC) is the most common type of laryngeal cancer, with around 60% of patients being diagnosed at an advanced stage. Recently, cancer-derived sialylated immunoglobulin G (SIA-IgG) has been suggested to play a role in the progression of various epithelial tumors, but its significance in LSCC remains unknown. This study aims to investigate the clinical significance of SIA-IgG as a novel biomarker in relation to the initiation, progression, and prognostication of LSCC.
Methods: Immunohistochemistry (IHC) were utilized to assess SIA-IgG expression in tumor samples from 75 LSCC patients, aiming to investigate its correlation with clinical prognosis. Vitro functional experiments were conducted to explore the impact of SIA-IgG expression on the proliferative and migratory abilities of laryngocarcinoma cells.
Results: High expression of SIA-IgG was associated with pT stage, pN stage, TNM stage, and recurrence during follow-up, and was correlated with poor disease-free survival (DFS) and overall survival (OS). Multivariate Cox analysis demonstrated that SIA-IgG served as an independent risk factor for OS and DFS. Knocking down SIA-IgG significantly weakened laryngocarcinoma cells' proliferation, clonogenesis, and migration abilities.
Conclusions: The frequent expression of SIA-IgG in LSCC is significantly associated with poor prognosis. High levels of SIA-IgG can enhance proliferation and migration in laryngocarcinoma cells. These findings suggest that SIA-IgG has potential as a novel biomarker for LSCC.
DOI: 10.6084/m9.figshare.28638560.v1
title: Basemap dataset

description: Standard map of China
DOI: 10.17632/kdf4tbdf9d
title: Effect of telemedicine-supported structured exercise program in patients with chronic low back pain: a randomized controlled trial

description: An open label, randomized controlled trial (RCT) was conducted over eight weekly sessions. Participants with CLBP were randomly assigned to either the Experimental Group (EG) or the Control Group (CG) in a 1:1 ratio, using a randomized numeric table. The EG will receive an intervention consisting of patient education, health coaching, and structured exercise program delivered through mobile health (mHealth) apps. The CG will receive usual care therapy, including patient education and paper handouts describing home exercises. The primary outcome measure was disability, assessed via the Roland Morris Disability Questionnaire (RMDQ). Secondary outcomes included pain intensity, mental health status, quality of life, walking ability, and exercise adherence. These were evaluated using the Numerical Rating Scale (NRS), Depression-Anxiety-Stress Scale (DASS21), 12-item Short Form Health Survey (SF-12), Time Up and Go (TUG), and Exercise Adherence Rating Scale (EARS), respectively. Linear mixed-effects model analysis was conducted at baseline, after 4 weeks (during treatment), and after 8 weeks (post-treatment), adhering to the principles of intention-to-treat (ITT) analysis. Data are available as Excel files.
DOI: 10.6084/m9.figshare.14152787.v1
title: Supplementary Material for: Effects of Exercise Dose and Detraining Duration on Mobility at Late Midlife: A Randomized Clinical Trial

description: <b><i>Background:</i></b> Office workers near retirement tend to be sedentary and can be prone to mobility limitations and diseases. We examined the dose effects of exergaming volume and duration of detraining on motor and cognitive function in office workers at late midlife to reduce sedentariness and mobility limitations. <b><i>Methods:</i></b> In an assessor-blinded randomized trial, 160 workers aged 55–65 years performed physically active video games in a nonimmersive form of virtual reality (exergaming) in small, supervised groups for 1 h, 1×, 2×, or 3×/week for 8 weeks followed by detraining for 8 and 16 weeks. Exergaming comprises high-intensity, full-body sensorimotor coordination, balance, endurance, and strengthening exercises. The primary outcome was the 6-minute walk test (6MWT), and secondary outcomes were body mass, self-reported physical activity, sleep quality, Berg Balance Scale, Short Physical Performance Battery, fast gait speed, dynamic balance, heart rate recovery after step test, and 6 cognitive tests. <b><i>Results:</i></b> The 3 groups were not different in any of the outcomes at baseline (all <i>p</i> &gt; 0.05). The outcomes were stable and had acceptable reliability (intraclass correlation coefficients ≥0.334) over an 8-week control period. Training produced an inverted U-shaped dose response of no (1×), most (2×), and medium (3×/week) effects of exergaming volume in most motor and selected cognitive outcomes. The distance walked in the 6MWT (primary outcome) increased most (94 m, 19%, <i>p</i> &lt; 0.05), medium (57 m, 12%, <i>p</i> &lt; 0.05), and least (4 m, 1%) after exergaming 2×, 3×, or 0× (control) (all different <i>p</i> &lt; 0.05). The highest responders tended to retain the exercise effects over 8 weeks of detraining, independent of training volume. This maintenance effect was less consistent after 16 weeks of detraining. <b><i>Conclusion:</i></b> Less was more during training and lasted longer after detraining. A medium dose volume of exergaming produced the largest clinically meaningful improvements in mobility and selected cognitive tests in 60-year-old office workers with mild mobility limitations and intact cognition.
DOI: 10.6084/m9.figshare.7741982.v2
title: Alterations of skeletal muscle bioenergetics in a mouse with F508del mutation leading to a cystic fibrosis-like condition

description: Figure 1S. State 4 respiratory rates of skeletal muscle subsarcolemmal (a) and interfibrillar (b) mitochondria in presence of mitochondria substrates for: complex I (malate and glutamate, G<sub>M</sub>), (malate and pyruvate, P<sub>M</sub>); complex II (succinate and rotenone, S<sub>R</sub>); complex III (duroquinol and rotenone, (DHQ<sub>R</sub>); complex IV (TMPD, ascorbate and rotenone, TMPD+A)<sub>R</sub>. * p&lt;0.05 WT (n=6) vs. CF (n=7), Mean ± standard deviation. Figure 2S. The ratio ADP to atomic oxygen phosphorylation (ADP/O) of skeletal muscle SSM (a) and IFM (b) in CF and WT mice. Complex I (malate and glutamate, G<sub>M</sub>; malate and pyruvate, P<sub>M</sub>); complex II (succinate and rotenone, S<sub>R</sub>); complex III (duroquinol and rotenone, (DHQ<sub>R</sub>). * p&lt;0.05 WT (n=6) vs. CF (n=7), Mean ± standard deviation.
DOI: 10.6084/m9.figshare.12577724.v1
title: JVASP-59035 to JVASP-60610

description: JARVIS-DFT input/output files
DOI: 10.6084/m9.figshare.25102526.v1
title: Supplementary Material for: Serum Growth Differentiation Factor 15 Levels Predict the Incidence of Frailty Among Patients with Cardiometabolic Diseases

description: Introduction: Frailty is a crucial health issue among older adults. Growth differentiation factor 15 (GDF15) is associated with inflammation, oxidative stress, insulin resistance, and mitochondrial dysfunction, which are possible pathogeneses of frailty. However, few longitudinal studies have investigated the association between GDF15 and the incidence of frailty. Therefore, we investigated whether high serum GDF15 levels are associated with the incidence of frailty.
Methods: A total of 175 older adults (mean age : 77 ± 6 years; 63% women) with cardiometabolic diseases and no frailty out of the two criteria at baseline participated. Individuals with severe renal impairment or severe cognitive impairment were excluded. Serum GDF15 levels were measured at baseline. Patients were asked to assess frailty status at baseline and annually during follow-up using the modified version of the Cardiovascular Health Study (mCHS) and the Kihon Checklist (KCL). We examined the association between GDF15 tertiles and each frailty measure during follow-up (median 38–39 months). In the multivariate Cox regression analysis, with the GDF15 tertile groups as the explanatory variables, hazard ratios (HRs) and 95% confidence intervals (CIs) for incident frailty were calculated after adjusting for covariates and using the lowest tertile group as the reference. 
Results: During the follow-up period, 25.6% and 34.0% of patients developed frailty, as defined by the mCHS and KCL, respectively. The highest GDF15 tertile group had a significantly higher incidence of mCHS- or KCL-defined frailty than the lowest GDF15 tertile group. Multivariate Cox regression analysis revealed that the adjusted HRs for incident mCHS- and KCL-defined frailty in the highest GDF15 tertile group were 3.9 (95% CI: 1.3–12.0) and 2.7 (95% CI: 1.1–6.9), respectively.
Conclusion: High serum GDF15 levels predicted the incidence of frailty among older adults with cardiometabolic diseases and could be an effective marker of the risk for frailty in interventions aimed at preventing frailty, such as exercise and nutrition.
DOI: 10.6084/m9.figshare.28195514.v3
title: Francisella tularensis wgMLST scheme.

description: Backup of the BioNumerics Francisella tularensis wgMLST scheme.
DOI: 10.6084/m9.figshare.28750532.v1
title: Working environments: a short overview of the literature

description: We rarely consider whether staff on our campuses are enjoying their work environments and are able to be their most creative and effective selves. We should ask individuals how they work best, to enable them to thrive. Staff should be given the freedom to experiment with different settings, without others imposing judgments based on their own limited perspectives. Here in the first of two blogs Nic Kipar reviews what we know from research about working environments; the second blog will look at what this might mean in practice.
DOI: 10.6084/m9.figshare.8206907.v1
title: Relato I Encontro de Agrofloresta para Mulheres

description: Relato das experiências e aprendizados vivenciados no I Encontro de Agrofloresta para Mulheres <br>Local: Sítio Selva e Paz, cidade de Piraí do Norte - Bahia<br>Dias 24, 25 e 26 de maio de 2019<br>O Encontro foi organizado pelo MAIS e facilitado por Gudrun Götsch. Em anexo, está o arquivo intitulado:<br>- Relato I Encontro Agrofloresta Mulheres_Roberta Schardong_mai.2019<br>O relato resume e sistematiza as experiências e aprendizados durante o encontro e também os momentos especiais que o lugar proporciona. <br>Também estão, em anexo, as filmagens realizadas durante o Encontro por participantes que, gentilmente, compartilharam.<br>No dia 27 de maio, período da manhã, foi realizada visita à propriedade de Ernst Götsch que mostrou os estratos no ambiente de plantio de cacau e explicou a importância fundamental da criação de processos na agricultura sintópica. O momento foi filmado e os vídeos estão acima.
DOI: 10.6084/m9.figshare.13332515.v1
title: Supplementary Material for: Healthcare Professional Clinical Actions following Nutrigenomics Testing in Practice

description: <b><i>Background:</i></b> Clinical demand for nutrigenomics testing (NGT) is increasing, underscoring the importance of assessing healthcare professional (HCP) competence and clinical actions with NGT in practice. While previous studies have explored HCP perceptions of NGT, no study has examined real HCP experiences with NGT in practice. <b><i>Objective:</i></b> The objective of this study was to evaluate the clinical experience of providing NGT among early adopter HCPs who have used NGT in their practice. We hypothesized that HCP clinical actions after NGT would differ according to HCP personal experience undergoing genetic testing (GT) as well as years in practice. <b><i>Design:</i></b> An online survey questionnaire was administered to HCPs (<i>n</i> = 70) who have provided NGT in practice. χ<sup>2</sup> tests, tests for trend, and logistic regression were used to compare HCP characteristics with post-NGT outcomes. <b><i>Results:</i></b> HCPs with fewest years in practice (&lt;5 years) comprised the lowest proportion of respondents (16%). Most HCPs reported good understanding of NGT results and 92% made genetic-based dietary recommendations to patients following NGT. HCP personal use of GT increased significantly with increasing years in practice (&lt;5 years: 36%, 5–10 years: 53%, 11–20 years: 70%, and &gt;20 years: 85%, <i>p</i> trend = 0.003). Requesting patient bloodwork because of NGT results increased significantly with HCP years in practice when HCPs with &lt;5 years in practice were not considered (5–10 years: 19%, 11–20 years: 28%, and &gt;20 years: 60%, <i>p</i> trend = 0.010). A near significant difference was observed where a greater proportion of HCPs who had personally undergone GT reported requesting patient bloodwork (personal use: 46% vs. no personal use: 23%, <i>p</i>-χ<sup>2</sup> = 0.066). <b><i>Conclusion:</i></b> Early HCP adopters of NGT utilize the test results to provide genetic-based dietary recommendations to patients. Clinical action after NGT currently appears to be driven by HCP years in practice, but HCP personal use of GT may also be a factor.
DOI: 10.6084/m9.figshare.12024840.v1
title: FTIR raw spectra of beech and oak specimens.zip

description: FTIR analysis of chemical changes in wood induced by steaming and longitudinal compression.<br>All raw and pre-processed FTIR spectra of measured specimens. Other informations can be found in the linked article.<br>
DOI: 10.17632/b89rhwhrrk
title: Mapping Sound Pressure Level of a Circular Piston (supplementary material)

description: The present set contains three Matlab scripts and two numerical data .txt files as supplementary material to a paper dedicated to a novel approach for determining the SPL near field and far field boundary of a circular piston (loudspeaker).
DOI: 10.6084/m9.figshare.20732095.v1
title: Process model simulated scenarios (BPMN)

description: The dataset contains 21 process models with a variety in process structure and behavior. These models also have the simulation parameters to simulate the process using BIMP (https://bimp.cs.ut.ee/)
DOI: 10.6084/m9.figshare.21290823.v1
title: Data for "A Homology Guide for Pacific Salmon Genus Oncorhynchus resolves patterns of Duplicate Retention, Rediploidization and Local Adaptation Following the Salmonid Specific Whole Genome Duplication Event"

description: This file contains all of the code and raw data required to recreate the findings related to the retention/rediplodization of gene families following the SS4R event in six species of Pacific Salmon.
DOI: 10.6084/m9.figshare.5125594.v1
title: Supplementary Material for: Prestroke Dementia: Characteristics and Clinical Features in Consecutive Series of Patients

description: <b><i>Background/Aim:</i></b> The prestroke level of cognitive function should be taken into account in order to predict the impact of stroke on the subsequent risk of dementia. The aim of the present study was to investigate the presence and correlates of prestroke dementia (PSD) as well as to identify its clinical features. <b><i>Methods:</i></b> Premorbid clinical and cognitive features of 158 consecutively recruited patients with a diagnosis of acute cerebrovascular pathology were assessed by interviewing the caregivers using multidimensional assessment. Patients were divided into two groups (PSD group and prestroke nondemented group). Baseline cognitive, functional and behavioral variables and neuroradiological hallmarks (medial temporal lobe atrophy, MTLA) were compared between these two groups. <b><i>Results:</i></b> In a logistic regression model, older age (OR 1.05), female gender (OR 2.3), Neuropsychiatric Inventory total score (OR 1.1) and MTLA (OR 1.2) were the variables independently associated with PSD. <b><i>Conclusions:</i></b> These findings support the hypothesis that cognitive impairment in patients with stroke may not only be a direct consequence of the acute cerebrovascular event but also a consequence of underlying neurodegenerative pathology.
DOI: 10.6084/m9.figshare.16825312.v1
title: Supplementary Material for: Self-Rated Health and Frailty in Older Adults from the Population-Based Three-City Bordeaux Cohort

description: <b><i>Introduction:</i></b> This study aimed to investigate whether self-rated health (SRH) predict frailty and its components among community dwellers aged 75 years and older. <b><i>Methods:</i></b> We ran a cross-sectional and prospective analysis from 643 and 379 participants of the Bordeaux Center (France) of the Three-City Study, respectively. We assessed SRH using a single question with 5 response options. We defined frailty as having at least 3 out of the following 5 criteria: weight loss, exhaustion, slowness, weakness, and low energy expenditure. We used multivariate logistic regression and Cox proportional hazard models. <b><i>Results:</i></b> At baseline, poor SRH was significantly associated with frailty (odds ratio = 5.2; 95% confidence interval [CI]: 2.9–9.5) and its components except for weakness. In the prospective analysis on nonfrail participants, poor SRH was associated with the 4-year risk of slowness (hazard ratio [HR] = 1.7; 95% CI: 1.1–2.6) but not with that of frailty (HR = 1.6; 95% CI: 0.9–2.9) or the other components. <b><i>Conclusions:</i></b> In a French cohort of community dwellers aged 75 years or older, poorer SRH was associated with concomitant frailty and 70% higher risk of slowness over 4 years.
DOI: 10.6084/m9.figshare.28620071.v1
title: <b>Promoção da Ciência Aberta através da Alfabetização Midiática e Informacional (AMI) nas Instituições de Ensino de Ciências da Saúde: uma revisão de escopo</b>

description: A pandemia da Covid-19 evidenciou a necessidade de democratizar o acesso ao conhecimento científico, contrapondo-se à desinfodemia e promovendo a alfabetização midiática e informacional (AMI). A AMI é essencial para o desenvolvimento social sustentável e a formação de cidadãos críticos, especialmente no contexto da Ciência Aberta, que busca garantir equidade e acessibilidade ao conhecimento. No entanto, persistem desafios para a implementação desses conceitos nas instituições de ensino de Ciências da Saúde.O objetivo desta revisão de escopo é identificar e analisar os principais desafios na implementação da Ciência Aberta e da AMI nas instituições de ensino de Ciências da Saúde. Trata-se de uma pesquisa de abordagem qualitativa e exploratória, com método bibliográfico, utilizando a Revisão de Escopo (<i>Scoping Review</i>) baseada na metodologia do Joanna Briggs Institute (JBI) e reportada conforme o PRISMA-ScR.A busca de estudos foi realizada nas bases Biblioteca Virtual da Saúde (BVS), PubMed, Scopus, Library, Information Science & Technology Abstracts (LISTA), e na literatura cinzenta nas bases Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e na Networked Digital Library of Theses and Dissertations (NDLTD), utilizando descritores do DeCS/MeSH sem restrições geográficas ou temporais. A estratégia de busca recuperou <b>629 estudos</b>, dos quais <b>7</b> foram incluídos. Os resultados apontam desafios estruturais, pedagógicos e culturais para a adoção da Ciência Aberta e da AMI, evidenciando a necessidade de capacitação docente, desenvolvimento de infraestrutura tecnológica e mudanças institucionais. Conclui-se que, apesar das barreiras, a adoção desses conceitos pode fortalecer a formação crítica dos profissionais de saúde e promover a transparência e equidade no acesso à informação científica.
DOI: 10.6084/m9.figshare.7950959.v1
title: gVCF_NA21093

description: 1000 Genomes gVCF mapped to hs37d5 for NA21093. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.17632/n46pws4vnb
title: Acute Effects of Tissue Flossing on Boxers with Chronic Knee

description: This study explored the effects of acute tissue flossing on boxers with chronic knee pain (CKP). Eighteen boxers with CKP were randomly divided into experimental (EG) and control (CG) groups. The visual analog scale (VAS), Lysholm knee function score, flexion range of motion (ROM), maximal isometric extensor muscle strength, and stability of the knee were measured pre- and post- intervention (EG: 3-minute tissue flossing, CG: rest). VAS (F = 15.849, p = 0.001) and Lysholm knee function (F = 9.327, p = 0.008) improved more in the EG than in the CG. There was a significant difference for maximal isometric extensor muscle strength (F = 17.769, p = 0.001) but no significant difference for ROM (F = 1.218, p = 0.287) and knee stability (H = 1.672, p = 0.196) between the EG and CG. The findings suggest that tissue flossing can reduce knee pain, improve function, and increase extensor strength in boxers with CKP.
DOI: 10.6084/m9.figshare.25375260.v1
title: Social media use by young people with language disorders: a scoping review

description: Social media are widely used by young people (YP), but how YP with language disorders use social media for social interaction remains insufficiently studied. This article provides an overview of the research on social media use by YP with language disorders. A scoping review was conducted, guided by a five-stage framework. Ten databases were searched (CENTRAL, CINAHL, ERIC, LLBA, Medline, PsychINFO, Scopus, speechBITE, Web of Science, ProQuest Dissertations & Theses Global). Chaining searches of papers identified for inclusion were conducted. After screening 199 unique papers, 44 were included. Findings revealed that YP with language disorders use social media less compared to typically developing peers; their profile of communication difficulties may impact the types of social media with which they engage. Although intervention studies are limited, the results offer encouraging findings regarding the positive impact of support for use of social media. Barriers and facilitators for social media use are identified. YP with language disorders use social media for social purposes. However, co-designed research into what YP with language disorders perceive their social media needs to be is urgently needed. How to support YP with language disorders to use social media is subject to future investigation. Young people with language disorders are likely using a range of social media to support their social participation, but they use social media less than typically developing peers.The types of social media young people with language disorders choose to engage with may be impacted by their language/literacy difficulties.There is preliminary evidence that intervention to support the use of social media by young people with language disorders is beneficial, but more research is required to identify the components to include in social media use training programs.To support the access to and use of social media by young people with language disorders, healthcare professionals may need to collaborate with parents and schools. Young people with language disorders are likely using a range of social media to support their social participation, but they use social media less than typically developing peers. The types of social media young people with language disorders choose to engage with may be impacted by their language/literacy difficulties. There is preliminary evidence that intervention to support the use of social media by young people with language disorders is beneficial, but more research is required to identify the components to include in social media use training programs. To support the access to and use of social media by young people with language disorders, healthcare professionals may need to collaborate with parents and schools.