cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9594341
title: Two-Stage Adaptive Designs for Three-Treatment Bioequivalence Studies

description: Bioequivalence (BE) studies are most often conducted as crossover trials, and therefore establishing their required sample size necessitates specification of the within-person variance. Given that this specification is often difficult in practice, there has been great interest in recent years in the use of adaptive designs for BE trials. However, while numerous methods for this have now been presented, their focus has been solely on two-treatment BE studies. In some instances, it will be desired to incorporate more than a single test and reference formulation into a BE trial. It would therefore be useful to establish methodology for the design of adaptive multi-treatment BE trials, to acquire the benefits in the two-treatment setting in this more complex situation. Here, we achieve this for three-treatment studies by extending previously proposed designs for two-treatment trials. First, we discuss the additional design considerations that arise when multiple comparisons are made. Next, an extensive simulation study is employed to compare the performance of the proposed procedures. With this, we demonstrate that two-stage designs with desirable statistical operating characteristics can be readily identified for three-treatment BE trials. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.9594341.v2
title: Two-Stage Adaptive Designs for Three-Treatment Bioequivalence Studies

description: Bioequivalence (BE) studies are most often conducted as crossover trials, and therefore establishing their required sample size necessitates specification of the within-person variance. Given that this specification is often difficult in practice, there has been great interest in recent years in the use of adaptive designs for BE trials. However, while numerous methods for this have now been presented, their focus has been solely on two-treatment BE studies. In some instances, it will be desired to incorporate more than a single test and reference formulation into a BE trial. It would therefore be useful to establish methodology for the design of adaptive multi-treatment BE trials, to acquire the benefits in the two-treatment setting in this more complex situation. Here, we achieve this for three-treatment studies by extending previously proposed designs for two-treatment trials. First, we discuss the additional design considerations that arise when multiple comparisons are made. Next, an extensive simulation study is employed to compare the performance of the proposed procedures. With this, we demonstrate that two-stage designs with desirable statistical operating characteristics can be readily identified for three-treatment BE trials. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.9593915
title: Processed Data- Revised

description: Processed Data of Creep Testing and Thermoelectric properties measurement
DOI: 10.6084/m9.figshare.9594341.v1
title: Two-stage adaptive designs for three-treatment bioequivalence studies

description: Bioequivalence studies are most often conducted as crossover trials, and therefore establishing their required sample size necessitates specification of the within-person variance. Given that this specification is often difficult in practice, there has been great interest in recent years in the use of adaptive designs for bioequivalence trials. However, whilst numerous methods for this have now been presented, their focus has been solely on two-treatment bioequivalence studies. In some instances, it will be desired to incorporate more than a single test and reference formulation into a bioequivalence trial. It would therefore be useful to establish methodology for the design of adaptive multi-treatment bioequivalence trials, in order to acquire the benefits in the two-treatment setting in this more complex situation. Here, we achieve this for three-treatment studies by extending previously proposed designs for two-treatment trials. First, we discuss the additional design considerations that arise when multiple comparisons are made. Next, an extensive simulation study is employed to compare the performance of the proposed procedures. With this, we demonstrate that two-stage designs with desirable statistical operating characteristics can be readily identified for three-treatment bioequivalence trials.
DOI: 10.6084/m9.figshare.9588887
title: In Colombia the Eurasian fungus <i>Amanita muscaria</i> is expanding its range into native, tropical <i>Quercus humboldtii</i> forests

description: To meet a global demand for timber, tree plantations were established in South America during the first half of the 20th century. Extensive plantings of non-native species now are found in Brazil, Chile, Argentina, and Uruguay. In Colombia, miscellaneous plantations were established in the 1950s, during a period of intensive local logging, when policies to limit deforestation in native <i>Quercus humboldtii</i> forests were established. One unforeseen consequence of planting non-native trees was the simultaneous introduction and subsequent persistence of ectomycorrhizal fungi. We sought to document the origins and spread of the introduced <i>Amanita muscaria</i> found in Colombian plantations of the Mexican species <i>Pinus patula</i>, North American species <i>P. taeda</i>, and Australian species <i>Acacia melanoxylon</i> and <i>Eucalyptus globulus</i>. In Colombia, <i>Amanita muscaria</i> is establishing a novel association with native <i>Q. humboldtii</i> and has spread to local <i>Q. humboldtii</i> forests. According to a Bayesian phylogeny and haplotype analysis based on the nuclear rDNA internal transcribed spacer region ITS1-5.8-ITS2 (ITS barcode), <i>A. muscaria</i> individuals found in four exotic plant species, and those colonizing <i>Q. humboldtii</i> roots, have a Eurasian origin and belong to two Eurasian haplotypes. This is the first time the spread of an introduced mutualist fungus into native Colombian <i>Q. humboldtii</i> forests is reported. To arrest its spread, we suggest the use of local inocula made up of native fungi, instead of inocula of introduced fungi.
DOI: 10.6084/m9.figshare.9588887.v1
title: In Colombia the Eurasian fungus <i>Amanita muscaria</i> is expanding its range into native, tropical <i>Quercus humboldtii</i> forests

description: To meet a global demand for timber, tree plantations were established in South America during the first half of the 20th century. Extensive plantings of non-native species now are found in Brazil, Chile, Argentina, and Uruguay. In Colombia, miscellaneous plantations were established in the 1950s, during a period of intensive local logging, when policies to limit deforestation in native <i>Quercus humboldtii</i> forests were established. One unforeseen consequence of planting non-native trees was the simultaneous introduction and subsequent persistence of ectomycorrhizal fungi. We sought to document the origins and spread of the introduced <i>Amanita muscaria</i> found in Colombian plantations of the Mexican species <i>Pinus patula</i>, North American species <i>P. taeda</i>, and Australian species <i>Acacia melanoxylon</i> and <i>Eucalyptus globulus</i>. In Colombia, <i>Amanita muscaria</i> is establishing a novel association with native <i>Q. humboldtii</i> and has spread to local <i>Q. humboldtii</i> forests. According to a Bayesian phylogeny and haplotype analysis based on the nuclear rDNA internal transcribed spacer region ITS1-5.8-ITS2 (ITS barcode), <i>A. muscaria</i> individuals found in four exotic plant species, and those colonizing <i>Q. humboldtii</i> roots, have a Eurasian origin and belong to two Eurasian haplotypes. This is the first time the spread of an introduced mutualist fungus into native Colombian <i>Q. humboldtii</i> forests is reported. To arrest its spread, we suggest the use of local inocula made up of native fungi, instead of inocula of introduced fungi.
DOI: 10.6084/m9.figshare.9588161
title: Identifying motorist characteristics associated with youth bicycle–motor vehicle collisions

description: <b>Objective:</b> The objective of this study was to identify driver characteristics associated with youth bicycle–motor vehicle collisions in Alberta, Canada. <b>Methods:</b> Edmonton and Calgary police collision report data from the years 2010–2014 were used. From these data, motor vehicle collisions involving youth (&lt;18 years old) were identified (cases). The controls were drivers who, over the same period, were involved in separate motor vehicle–only collisions but deemed not at fault using an automated culpability analysis. Control selection used the quasi-induced exposure method, assuming that not-at-fault drivers in collisions are representative of the typical driver (source population). Descriptive statistics, including proportions, medians, and interquartile ranges (as appropriate) were used to describe the characteristics of the case and control drivers. Purposeful variable selection techniques were used to inform multivariable logistic regression models and results are presented as adjusted odds ratios (aORs) and 95% confidence intervals (CIs). <b>Results:</b> Four hundred twenty-three drivers involved in youth bicycle–motor vehicle collisions were identified, as were 243,927 not-at-fault control drivers. Drivers &gt;54 years old had higher odds of involvement in youth bicycle–motor vehicle collisions than drivers between 25 and 39 years old (aOR = 1.37; 95% CI, 1.03, 1.82). Compared to driving between 3:01 p.m. and 6:00 p.m., driving between 12:01 a.m. and 6:00 a.m. (aOR = 0.27; 95% CI, 0.11, 0.66), between 6:01 a.m. and 9:00 a.m. (aOR = 0.61; 95% CI, 0.44, 0.85), or between 9:01 a.m. and 12:00 p.m. (aOR = 0.26; 95% CI, 0.16, 0.41) had lower odds of bicyclist collision, whereas driving between 6:01 p.m. and 12:00 a.m. had higher odds (aOR = 1.34; 95% CI, 1.01, 1.79). Driving a truck/van had lower odds of bicyclist collision compared to driving a passenger car (aOR = 0.67; 95% CI, 0.48, 0.94). <b>Conclusions:</b> Culpability analysis is typically applied to motorists to identify transient exposures; however, this study used culpability analysis to select control drivers who could be compared with drivers involved in youth bicycle–motor vehicle collisions. This study highlights motorist characteristics in youth bicycle–motor vehicle collisions. In doing so, we hope to inform primary prevention strategies for motorists and the environment that will reduce collisions.
DOI: 10.6084/m9.figshare.9588161.v1
title: Identifying motorist characteristics associated with youth bicycle–motor vehicle collisions

description: <b>Objective:</b> The objective of this study was to identify driver characteristics associated with youth bicycle–motor vehicle collisions in Alberta, Canada. <b>Methods:</b> Edmonton and Calgary police collision report data from the years 2010–2014 were used. From these data, motor vehicle collisions involving youth (&lt;18 years old) were identified (cases). The controls were drivers who, over the same period, were involved in separate motor vehicle–only collisions but deemed not at fault using an automated culpability analysis. Control selection used the quasi-induced exposure method, assuming that not-at-fault drivers in collisions are representative of the typical driver (source population). Descriptive statistics, including proportions, medians, and interquartile ranges (as appropriate) were used to describe the characteristics of the case and control drivers. Purposeful variable selection techniques were used to inform multivariable logistic regression models and results are presented as adjusted odds ratios (aORs) and 95% confidence intervals (CIs). <b>Results:</b> Four hundred twenty-three drivers involved in youth bicycle–motor vehicle collisions were identified, as were 243,927 not-at-fault control drivers. Drivers &gt;54 years old had higher odds of involvement in youth bicycle–motor vehicle collisions than drivers between 25 and 39 years old (aOR = 1.37; 95% CI, 1.03, 1.82). Compared to driving between 3:01 p.m. and 6:00 p.m., driving between 12:01 a.m. and 6:00 a.m. (aOR = 0.27; 95% CI, 0.11, 0.66), between 6:01 a.m. and 9:00 a.m. (aOR = 0.61; 95% CI, 0.44, 0.85), or between 9:01 a.m. and 12:00 p.m. (aOR = 0.26; 95% CI, 0.16, 0.41) had lower odds of bicyclist collision, whereas driving between 6:01 p.m. and 12:00 a.m. had higher odds (aOR = 1.34; 95% CI, 1.01, 1.79). Driving a truck/van had lower odds of bicyclist collision compared to driving a passenger car (aOR = 0.67; 95% CI, 0.48, 0.94). <b>Conclusions:</b> Culpability analysis is typically applied to motorists to identify transient exposures; however, this study used culpability analysis to select control drivers who could be compared with drivers involved in youth bicycle–motor vehicle collisions. This study highlights motorist characteristics in youth bicycle–motor vehicle collisions. In doing so, we hope to inform primary prevention strategies for motorists and the environment that will reduce collisions.
DOI: 10.6084/m9.figshare.9587888
title: data.xlsx

description: it contains major and trace elements, carbon isotopic composition.
DOI: 10.6084/m9.figshare.9587888.v1
title: data.xlsx

description: it contains major and trace elements, carbon isotopic composition.
DOI: 10.15131/shef.data.9587873
title: VLF data collected during solar eclipse 21.08.2017

description: Raw data of the VLF observations collected during total solar eclipse 21.08.2017 (transmitters NAU, NML NPM)
DOI: 10.6084/m9.figshare.9587729
title: TEWL and corneometer readings

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.15131/shef.data.9587873.v1
title: VLF data collected during solar eclipse 21.08.2017

description: Raw data of the VLF observations collected during total solar eclipse 21.08.2017 (transmitters NAU, NML NPM)
DOI: 10.6084/m9.figshare.9587729.v1
title: TEWL and corneometer readings

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587489
title: Histology quantification

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587654
title: Lucifer yellow dye penetration quantification

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587489.v1
title: Histology quantification

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587654.v1
title: Lucifer yellow dye penetration quantification

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587024
title: FLG qPCR data

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587060
title: H&E images - replicate 1

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587024.v1
title: FLG qPCR data

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9587060.v1
title: H&E images - replicate 1

description: Raw data for Elias et al. submitted to Wellcome Open Research
DOI: 10.6084/m9.figshare.9586898

description: Raw data for Elias et al. submitted to Wellcome Open Research<br>
DOI: 10.6084/m9.figshare.9586913
title: HPLC, XPS, XRD Data

description: HPLC Data, XPS data, XRD data and SEM data<br>
DOI: 10.6084/m9.figshare.9586589
title: Data and results: Phase equilibria constraints on crystallization differentiation: insights into the petrogenesis of the normally zoned Buddusò Pluton in north-central Sardinia

description: Analytical methods, whole-rock geochemical and geochronological data and results of phase-equilibria simulations.
DOI: 10.6084/m9.figshare.9586898.v1
title: Filaggrin densitometry data

description: Raw data for Elias et al. submitted to Wellcome Open Research<br>
DOI: 10.6084/m9.figshare.9586589.v1
title: Data and results: Phase equilibria constraints on crystallization differentiation: insights into the petrogenesis of the normally zoned Buddusò Pluton in north-central Sardinia

description: Analytical methods, whole-rock geochemical and geochronological data and results of phase-equilibria simulations.
DOI: 10.6084/m9.figshare.9586532
title: TempEval-3 data

description: Data, submissions, and intermediate files from TempEval-3 held in 2013. Annotated in TimeML and TimeML strict. Includes silver data and TLINK merging tools.
DOI: 10.6084/m9.figshare.9586913.v1
title: HPLC, XPS, XRD Data

description: HPLC Data, XPS data, XRD data and SEM data<br>
DOI: 10.6084/m9.figshare.9585914
title: Microplastics Santa Catarina Island

description: Data regarding oxidation indices for pellets collectd at Santa Catatina Island sandy beaches.
DOI: 10.6084/m9.figshare.9585914.v1
title: Microplastics Santa Catarina Island

description: Data regarding oxidation indices for pellets collectd at Santa Catatina Island sandy beaches.
DOI: 10.6084/m9.figshare.9585350
title: AJP Endo Hormone Supplement.08-01-19.Final.docx

description: The online document contains further details of methodologies and supplemental data.
DOI: 10.6084/m9.figshare.9585410
title: Data for "Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity"

description: This repository contains the data described in the manuscript "Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity?" published in Nature Scientific Reports (doi: will be added when available). An extensive description of the published data will be given in the readme.txt.<br>- Average geometry of the healthy nasal cavity: The average geometry of the healthy nasal cavity generated using the statistical shape model described in the manuscript is provided in two file formats. An .stl-file with ASCII encoding and a .surf-file in ASCII encoding. The formatting of the latter file is specified in the readme file.<br>- Individual wall-bound distributions: All 25 patient-specific distributions of the wall shear stress and static pressure that were calculated during inspiration and expiraton respectively are made available via the individualDistributions.zip archive. All individual files are written in as ASCII files. More details regarding the formatting of those files is given in the readme file.<br>- Average Distributions: The averages of the individual distributions are made available via the averageDistributions.zip archive.<br>- SSM Distributions: The distributions of wall shear stresses and static pressure calculated for the average geometry during inspiration and expiration are made available via the SSMDistributions.zip archive.<br>- Integral measures: A table containing all integral measures calculated and reported within the manuscript can be found in the Excel file "integralMeasures_healthySubjects.xlsx".<br>- MATLAB Files for Data Processing: MATLAB functions for reading the surface and data files are made available via the MATLAB_readAMIRA.zip archive.<br>- data that might be added later: We are currently discussing whether we are allowed to publish the patient-specific geometries. If we get the required permissions, this data will also be added. <br><br>If any additional data is required or if you have questions regarding the data, don't hestitate to ask.<br><br><br>
DOI: 10.6084/m9.figshare.9585275
title: Summary statistics of eQTL and response eQTL analysis in neonatal immune cells

description: These files contain the summary statistics of the eQTL analysis in the manuscript titled “Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk”. Read https://www.biorxiv.org/content/10.1101/683086v1for detailed methods. The four files named with “Full_summary_stat_eQTL” contains full summary statistics of eQTL analysis in the following four experimental conditions: resting monocytes, LPS-stimulated monocytes, resting T cells, and PHA-stimulated T cells. The statistics were calculated using the <i>Matrix eQTL</i>R package. Significant eGenes are listed in Table S1–4. The two files named with “Interaction_test_reQTL” contains fulll summary statistics of the interaction tests used for response eQTL (reQTL) detection in monocytes and in T cells. Significant reQTLs (FDR ≤0.05) are listed in Table S7–8. Table legend is similar to that for Table S7–8.
DOI: 10.6084/m9.figshare.9585275.v2
title: Summary statistics of eQTL and response eQTL analysis in neonatal immune cells

description: These files contain the summary statistics of the eQTL analysis in the manuscript titled “Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk”. Read https://www.biorxiv.org/content/10.1101/683086v1for detailed methods. The four files named with “Full_summary_stat_eQTL” contains full summary statistics of eQTL analysis in the following four experimental conditions: resting monocytes, LPS-stimulated monocytes, resting T cells, and PHA-stimulated T cells. The statistics were calculated using the <i>Matrix eQTL</i>R package. Significant eGenes are listed in Table S1–4. The two files named with “Interaction_test_reQTL” contains fulll summary statistics of the interaction tests used for response eQTL (reQTL) detection in monocytes and in T cells. Significant reQTLs (FDR ≤0.05) are listed in Table S7–8. Table legend is similar to that for Table S7–8.
DOI: 10.6084/m9.figshare.9585410.v1
title: Data for "Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity?"

description: This repository contains the data described in the manuscript "Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity?" published in Nature Scientific Reports (doi: will be added when available).An extensive description of the published data is given in the readme.txt.<br>- Average geometry of the healthy nasal cavity: The average geometry of the healthy nasal cavity generated using the statistical shape model described in the manuscript is provided in two file formats. An .stl-file with ASCII encoding and a .surf-file in ASCII encoding. The formatting of the latter file is specified in the readme file.<br>- Individual wall-bound distributions: All 25 patient-specific distributions of the wall shear stress and static pressure that were calculated during inspiration and expiraton respectively are made available via the individualDistributions.zip archive. All individual files are written in as ASCII files. More details regarding the formatting of those files is given in the readme file.<br>- Average Distributions: The averages of the individual distributions are made available via the averageDistributions.zip archive.<br>- SSM Distributions: The distributions of wall shear stresses and static pressure calculated for the average geometry during inspiration and expiration are made available via the SSMDistributions.zip archive.<br>- Integral measures: A table containing all integral measures calculated and reported within the manuscript can be found in the Excel file "integralMeasures_healthySubjects.xlsx".<br>- MATLAB Files for Data Processing: MATLAB functions for reading the surface and data files are made available via the MATLAB_readAMIRA.zip archive.<br>- data that might be added later: We are currently discussing whether we are allowed to publish the patient-specific geometries. If we get the required permissions, this data will also be added. <br><br>If any additional data is required or if you have questions regarding the data, don't hestitate to ask.<br><br><br>