cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5709274.v1
title: Additional file 7: Table S4. of Identification of regulatory modules in genome scale transcription regulatory networks

description: Co-expression levels (PCC) for each CoReg modules. This table is ordered in the same way as the heatmap (XLSX 92 kb)
DOI: 10.6084/m9.figshare.5709286
title: Additional file 8: Table S5. of Identification of regulatory modules in genome scale transcription regulatory networks

description: P-values for co-expression analysis for Fig. 7 heatmap. (XLSX 96 kb)
DOI: 10.6084/m9.figshare.5709286.v1
title: Additional file 8: Table S5. of Identification of regulatory modules in genome scale transcription regulatory networks

description: P-values for co-expression analysis for Fig. 7 heatmap. (XLSX 96 kb)
DOI: 10.6084/m9.figshare.5709826
title: Phases of HeN4 and polymeric nitrogen t-N as a function of pressure

description: Structural (CIF) data
for each predicted phase of HeN4, and the output of an NVT-MD simulation of t-N at temperature ≈
1000 K and pressure ≈ 1atm.
DOI: 10.6084/m9.figshare.5709826.v1
title: Phases of HeN4 and polymeric nitrogen t-N as a function of pressure

description: Structural (CIF) data
for each predicted phase of HeN4, and the output of an NVT-MD simulation of t-N at temperature ≈
1000 K and pressure ≈ 1atm.
DOI: 10.6084/m9.figshare.5715286
title: A novel strain of <i>Pseudozyma aphidis</i> from mulberry parasitises the conidia of mulberry powdery mildew fungus <i>Phyllactinia</i> sp. and its biocontrol effect in the fields

description: Plant surface is colonised with a vast community of non-pathogenic epiphytic microorganisms which play an important role in host defence. In the present study, we reported a fungus from mulberry leaf surface that showed an antagonistic effect against mulberry powdery mildew fungal pathogen <i>Phyllactinia</i> sp. This novel isolate is a yeast-like fungus that was identified as <i>Pseudozyma aphidis</i> CNm2012 based on morphologic and phylogenetic analysis. According to our research, <i>P. aphidis</i> CNm2012 directly acted on the powdery mildew conidia via parasitism which caused conidial atrophy, collapse and eventually, cleavage and death. During the parasitic process, we found the isolate could gather around the conidia of <i>Phyllactinia</i> sp. and form hyphae that grew on the conidial surface and utilise the conidia as a nutrient source. Field studies revealed that <i>P. aphidis</i> CNm2012 could suppress the disease incidence of mulberry powdery mildew caused by <i>Phyllactinia</i> sp., and reduce the disease severity. To our knowledge, it is the first report of <i>P. aphidis</i> directly against powdery mildew fungus <i>Phyllactinia</i> spp. by parasitism. Our results indicated that <i>P. aphidis</i> CNm2012 could be served as an environmentally friendly alternative of chemical pesticides to manage mulberry powdery mildew disease.
DOI: 10.6084/m9.figshare.5715286.v1
title: A novel strain of <i>Pseudozyma aphidis</i> from mulberry parasitises the conidia of mulberry powdery mildew fungus <i>Phyllactinia</i> sp. and its biocontrol effect in the fields

description: Plant surface is colonised with a vast community of non-pathogenic epiphytic microorganisms which play an important role in host defence. In the present study, we reported a fungus from mulberry leaf surface that showed an antagonistic effect against mulberry powdery mildew fungal pathogen <i>Phyllactinia</i> sp. This novel isolate is a yeast-like fungus that was identified as <i>Pseudozyma aphidis</i> CNm2012 based on morphologic and phylogenetic analysis. According to our research, <i>P. aphidis</i> CNm2012 directly acted on the powdery mildew conidia via parasitism which caused conidial atrophy, collapse and eventually, cleavage and death. During the parasitic process, we found the isolate could gather around the conidia of <i>Phyllactinia</i> sp. and form hyphae that grew on the conidial surface and utilise the conidia as a nutrient source. Field studies revealed that <i>P. aphidis</i> CNm2012 could suppress the disease incidence of mulberry powdery mildew caused by <i>Phyllactinia</i> sp., and reduce the disease severity. To our knowledge, it is the first report of <i>P. aphidis</i> directly against powdery mildew fungus <i>Phyllactinia</i> spp. by parasitism. Our results indicated that <i>P. aphidis</i> CNm2012 could be served as an environmentally friendly alternative of chemical pesticides to manage mulberry powdery mildew disease.
DOI: 10.6084/m9.figshare.5715394
title: Additional file 2: of Gene expression, regulation of DEN and HBx induced HCC mice models and comparisons of tumor, para-tumor and normal tissues

description: Gene enrichment analysis of top 5% highly expressed genes of tumor tissue in DEN model and HBx model. (XLSX 57Â kb)
DOI: 10.6084/m9.figshare.5715394.v1
title: Additional file 2: of Gene expression, regulation of DEN and HBx induced HCC mice models and comparisons of tumor, para-tumor and normal tissues

description: Gene enrichment analysis of top 5% highly expressed genes of tumor tissue in DEN model and HBx model. (XLSX 57Â kb)
DOI: 10.6084/m9.figshare.5715451
title: Additional file 1: Table S1. of Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework

description: shows tools that use three-dimensional structural information from the Protein Data Bank to predict the effect of missense mutations. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.5715451.v1
title: Additional file 1: Table S1. of Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework

description: shows tools that use three-dimensional structural information from the Protein Data Bank to predict the effect of missense mutations. (XLSX 43 kb)
DOI: 10.6084/m9.figshare.5715631
title: Validating the analytic results (case 3 in Appendix B) from Matter rogue waves for the three-component Gross–Pitaevskii equations in the spinor Bose–Einstein condensates

description: Analytic results (case 3 in Appendix B) have been verified with Mathematica software
DOI: 10.6084/m9.figshare.5715631.v1
title: Validating the analytic results (case 3 in Appendix B) from Matter rogue waves for the three-component Gross–Pitaevskii equations in the spinor Bose–Einstein condensates

description: Analytic results (case 3 in Appendix B) have been verified with Mathematica software
DOI: 10.6084/m9.figshare.5715634
title: Validating the analytic results (case 2 in Appendix B) from Matter rogue waves for the three-component Gross–Pitaevskii equations in the spinor Bose–Einstein condensates

description: Analytic results (case 2 in Appendix B) have been verified with Mathematica software
DOI: 10.6084/m9.figshare.5715637
title: Validating the analytic results (case 1 in Appendix B) from Matter rogue waves for the three-component Gross–Pitaevskii equations in the spinor Bose–Einstein condensates

description: Analytic results (case 1 in Appendix B) have been verified with Mathematica software
DOI: 10.6084/m9.figshare.5716216
title: (Fig 5) Comparison of HbA1c measurements obtained from TAP device and venepuncture

description: We evaluated the performance of the TAP device for HbA1c
determinations in a clinical setting. Results from capillary blood samples
collected using the TAP device were compared to those from venous blood samples
collected by venepuncture using the DCA Vantage (Siemens) and the Afinion AS100
(Alere). The study was conducted at three hospital sites with 143 total
participants. The people who performed the blood collections were healthcare
workers trained in phlebotomy (e.g., nurses, phlebotomists).
DOI: 10.6084/m9.figshare.5716216.v1
title: (Fig 5) Comparison of HbA1c measurements obtained from TAP device and venepuncture

description: We evaluated the performance of the TAP device for HbA1c
determinations in a clinical setting. Results from capillary blood samples
collected using the TAP device were compared to those from venous blood samples
collected by venepuncture using the DCA Vantage (Siemens) and the Afinion AS100
(Alere). The study was conducted at three hospital sites with 143 total
participants. The people who performed the blood collections were healthcare
workers trained in phlebotomy (e.g., nurses, phlebotomists).
DOI: 10.6084/m9.figshare.5716240
title: (Fig 1a) Maximum velocity and acceleration of potential microneedle insertion mechanisms, analyzed by high-speed video

description: The motion of each commercially-available lancet and snap
dome was captured using a high-speed video camera. The videos were analyzed using
ProAnalyst software. The software was used to track a specified
point on each actuation mechanism in each frame of the video. The velocity and
acceleration were then determined for each actuation mechanism using the data
output from the software.
DOI: 10.6084/m9.figshare.5716240.v1
title: (Fig 1a) Maximum velocity and acceleration of potential microneedle insertion mechanisms, analyzed by high-speed video

description: The motion of each commercially-available lancet and snap
dome was captured using a high-speed video camera. The videos were analyzed using
ProAnalyst software. The software was used to track a specified
point on each actuation mechanism in each frame of the video. The velocity and
acceleration were then determined for each actuation mechanism using the data
output from the software.
DOI: 10.6084/m9.figshare.5716267
title: (Fig 1b) Optimization of microneedle length in device prototype development: the effect of microneedle length on blood flow rate and pain sensation.

description: To determine the optimal microneedle array dimensions for
use in our device, we began by evaluating the effect of microneedle length on
blood flow rate and perceived pain over a range of 750 to 1250 µm. This was
investigated by inserting microneedle arrays into the skin using a snap dome
mechanism and then applying vacuum to the puncture sites to encourage blood
flow. Pain sensation scores were obtained from each participant
immediately after each microneedle array actuation, using the Wong-Baker FACES
pain scale, with '0' corresponding to "no hurt" and '10'
corresponding to "hurts worse."
DOI: 10.6084/m9.figshare.5716267.v1
title: (Fig 1b) Optimization of microneedle length in device prototype development: the effect of microneedle length on blood flow rate and pain sensation.

description: To determine the optimal microneedle array dimensions for
use in our device, we began by evaluating the effect of microneedle length on
blood flow rate and perceived pain over a range of 750 to 1250 µm. This was
investigated by inserting microneedle arrays into the skin using a snap dome
mechanism and then applying vacuum to the puncture sites to encourage blood
flow. Pain sensation scores were obtained from each participant
immediately after each microneedle array actuation, using the Wong-Baker FACES
pain scale, with '0' corresponding to "no hurt" and '10'
corresponding to "hurts worse."
DOI: 10.6084/m9.figshare.5716276
title: (Fig 1d) The effect of applied vacuum on blood flow rate

description: We found that applying vacuum to the area
surrounding the microneedle puncture sites encourages localized blood flow,
stretches the puncture sites open, and leads to substantially increased blood
flow rates. To optimize the level of vacuum used for blood collection, we
tested devices with -5, -12, and -20 inHg of vacuum, using a vacuum reservoir connected
to each device.
DOI: 10.6084/m9.figshare.5716276.v1
title: (Fig 1d) The effect of applied vacuum on blood flow rate

description: We found that applying vacuum to the area
surrounding the microneedle puncture sites encourages localized blood flow,
stretches the puncture sites open, and leads to substantially increased blood
flow rates. To optimize the level of vacuum used for blood collection, we
tested devices with -5, -12, and -20 inHg of vacuum, using a vacuum reservoir connected
to each device.
DOI: 10.6084/m9.figshare.5716537
title: (Table 2) Anticoagulant release profile with and without controlled release feature

description: In vitro determination of heparin release was carried out
using partial devices built to allow visualization of the flow path. Blood
release from the skin was simulated using a syringe pump-controlled flow
system. Water was introduced to test devices at either 25 or 50 µL/min.
Aliquots of the rinse liquid were recovered from the reservoir side of the
devices throughout the collection. The concentration of heparin in the aliquots
was then measured using a colorimetric assay based on the metachromasia of
Azure A.
DOI: 10.6084/m9.figshare.5716537.v1
title: (Table 2) Anticoagulant release profile with and without controlled release feature

description: In vitro determination of heparin release was carried out
using partial devices built to allow visualization of the flow path. Blood
release from the skin was simulated using a syringe pump-controlled flow
system. Water was introduced to test devices at either 25 or 50 µL/min.
Aliquots of the rinse liquid were recovered from the reservoir side of the
devices throughout the collection. The concentration of heparin in the aliquots
was then measured using a colorimetric assay based on the metachromasia of
Azure A.
DOI: 10.6084/m9.figshare.5718322
title: (Table 1) Comparison of blood flow between forearm and upper arm

description: Comparison of flow rate (inferred from collected volume and collection duration) and pain score for the use of the integrated TAP device on forearm & upper arm.
DOI: 10.6084/m9.figshare.5718322.v1
title: (Table 1) Comparison of blood flow between forearm and upper arm

description: Comparison of flow rate (inferred from collected volume and collection duration) and pain score for the use of the integrated TAP device on forearm & upper arm.
DOI: 10.6084/m9.figshare.5718799
title: T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients

description: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. We reviewed the records of 117 SLE patients with infection and 61 SLE patients without infection. Changes in the levels of T cell subsets, immunoglobulin G (IgG), complement C3, complement C4, globulin, and anti-double-stranded DNA (anti-ds-DNA) were detected. CD4+ and CD4+/CD8+ T cell levels were significantly lower and CD8+ T cell levels were significantly greater in SLE patients with infection than in SLE patients without infection. Additionally, the concentrations of IgG in SLE patients with infection were significantly lower than those in SLE patients without infection. However, complement C3, complement C4, globulin, and anti-ds-DNA levels were not significantly different in SLE patients with and without infection. Therefore, clinical testing for T cell subsets and IgG is potentially useful for identifying the presence of infection in SLE patients and for distinguishing a lupus flare from an acute infection.
DOI: 10.6084/m9.figshare.5718799.v1
title: T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients

description: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. We reviewed the records of 117 SLE patients with infection and 61 SLE patients without infection. Changes in the levels of T cell subsets, immunoglobulin G (IgG), complement C3, complement C4, globulin, and anti-double-stranded DNA (anti-ds-DNA) were detected. CD4+ and CD4+/CD8+ T cell levels were significantly lower and CD8+ T cell levels were significantly greater in SLE patients with infection than in SLE patients without infection. Additionally, the concentrations of IgG in SLE patients with infection were significantly lower than those in SLE patients without infection. However, complement C3, complement C4, globulin, and anti-ds-DNA levels were not significantly different in SLE patients with and without infection. Therefore, clinical testing for T cell subsets and IgG is potentially useful for identifying the presence of infection in SLE patients and for distinguishing a lupus flare from an acute infection.
DOI: 10.6084/m9.figshare.5719210
title: Contribution of DNA repair xeroderma pigmentosum group D genotypes to pancreatic cancer risk in the Chinese Han population

description: Abstract This study aimed to determine the association between the polymorphisms and haplotypes in the xeroderma pigmentosum group D (XPD) gene and the risk of pancreatic cancer in the Chinese Han population. SNaPshot was used for genotyping six SNP sites of the XPD gene. Comparisons of the correlations between different genotypes in combination with smoking and the susceptibility to pancreatic cancer were performed. Individual pancreatic cancer risk in patients who carry mutant C alleles (AC, CC, and AC+CC) at rs13181 increased (p &lt; 0.05). Taking non-smoking individuals who carry the AA genotype as a reference, and non-smoking individuals who carry mutant allele C (AC+CC), the risk of pancreatic cancer increased by 3.343 times in individuals who smoked ≥ 20 cigarettes daily, 3.309 times in individuals who smoked ≥ 14 packs per year, 5.011 times in individuals who smoked ≥ 24 packs per year, and 4.013 times in the individuals who smoked ≥ 37 packs per year (P &lt; 0.05). In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p &lt; 0.05). We conclude that the polymorphism of XPD Lys751Gln (rs13181) in combination with smoking contributes to increased risk of pancreatic cancer in the Chinese Han population. Haplotype AGG might be a susceptibility haplotype for pancreatic cancer.
DOI: 10.6084/m9.figshare.5719210.v1
title: Contribution of DNA repair xeroderma pigmentosum group D genotypes to pancreatic cancer risk in the Chinese Han population

description: Abstract This study aimed to determine the association between the polymorphisms and haplotypes in the xeroderma pigmentosum group D (XPD) gene and the risk of pancreatic cancer in the Chinese Han population. SNaPshot was used for genotyping six SNP sites of the XPD gene. Comparisons of the correlations between different genotypes in combination with smoking and the susceptibility to pancreatic cancer were performed. Individual pancreatic cancer risk in patients who carry mutant C alleles (AC, CC, and AC+CC) at rs13181 increased (p &lt; 0.05). Taking non-smoking individuals who carry the AA genotype as a reference, and non-smoking individuals who carry mutant allele C (AC+CC), the risk of pancreatic cancer increased by 3.343 times in individuals who smoked ≥ 20 cigarettes daily, 3.309 times in individuals who smoked ≥ 14 packs per year, 5.011 times in individuals who smoked ≥ 24 packs per year, and 4.013 times in the individuals who smoked ≥ 37 packs per year (P &lt; 0.05). In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p &lt; 0.05). We conclude that the polymorphism of XPD Lys751Gln (rs13181) in combination with smoking contributes to increased risk of pancreatic cancer in the Chinese Han population. Haplotype AGG might be a susceptibility haplotype for pancreatic cancer.
DOI: 10.6084/m9.figshare.5719561
title: Thermal Dehydrogenation Characteristics of Li-Sr-Al-N-H Hydrogen Storage System

description: Thermolysis behavior of the Li-Sr-Al-N-H hydrogen storage system prepared by ball milling of Sr2AlH7 + LiNH2 mixture was investigated in this paper. The results show that thermal decomposition of the Li-Sr-Al-N-H system proceeds mainly in two steps with only hydrogen desorption. The thermal stability of this system is lowered as compared to the individual starting material, resulting in the hydrogen desorption initiating from about 125 °C. In addition, about 0.91 and 1.53 wt.% of hydrogen can be isothermally desorbed within 180 min at 180 and 330 °C, respectively. The decreased thermal stability of the Li-Sr-Al-N-H system might be attributed to the chemical reactions between the starting materials during the heating process with the formation of LiSrH3 and N-containing amorphous phases.
DOI: 10.6084/m9.figshare.5719561.v1
title: Thermal Dehydrogenation Characteristics of Li-Sr-Al-N-H Hydrogen Storage System

description: Thermolysis behavior of the Li-Sr-Al-N-H hydrogen storage system prepared by ball milling of Sr2AlH7 + LiNH2 mixture was investigated in this paper. The results show that thermal decomposition of the Li-Sr-Al-N-H system proceeds mainly in two steps with only hydrogen desorption. The thermal stability of this system is lowered as compared to the individual starting material, resulting in the hydrogen desorption initiating from about 125 °C. In addition, about 0.91 and 1.53 wt.% of hydrogen can be isothermally desorbed within 180 min at 180 and 330 °C, respectively. The decreased thermal stability of the Li-Sr-Al-N-H system might be attributed to the chemical reactions between the starting materials during the heating process with the formation of LiSrH3 and N-containing amorphous phases.
DOI: 10.6084/m9.figshare.5719930
title: Estimating population parameters of longsnout seahorses, Hippocampus reidi (Teleostei: Syngnathidae) through mark-recapture

description: ABSTRACT Estimating population parameters is essential for understanding the ecology of species, which ultimately helps to assess their conservation status. The seahorse Hippocampus reidi is directly exposed to anthropogenic threats along the Brazilian coast, but the species still figures as Data Deficient (DD) at IUCN’s Red List. To provide better information on the ecology of this species, we studied how population parameters vary over time in a natural subtropical environment. By combing mark-recapture models for open and closed populations, we estimated abundance, survival rate, emigration probability, and capture probability. We marked 111 individuals, which showed a 1:1 sex ratio, and an average size of 10.5 cm. The population showed high survival rate, low temporary emigration probability and variable capture probability and abundance. Our models considering relevant biological criteria illuminate the relatively poorly known population ecology and life history of seahorses. It is our hope that this study inspires the use of mark-recapture methods in other populations of H. reidi in a collective effort to properly assess their conservation status.