cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7783982.v1
title: Supplementary Material for: Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase Inhibitors

description: <b><i>Background:</i></b> The combination of growth hormone (GH) and aromatase inhibitors (AI) improves linear growth in severely short adolescent boys; however, the effects of this intervention on quality of life (QoL) are unknown. This study assesses whether GH, AI, or their combination impacts the QoL of adolescent males with idiopathic short stature (ISS) from both the adolescent and the parent perspective. <b><i>Method:</i></b> A randomized open-label comparator trial was conducted in 76 pubertal males with ISS who received AI, GH, or AI/GH for 24 months. The condition-specific Quality of Life in Short Stature Youth questionnaire was used to assess QoL. <b><i>Results:</i></b> QoL scores were low at baseline in the children’s and parents’ reports. Within-group testing showed that total QoL scores increased significantly at 24 months in the GH and AI/GH group but not the AI group in the children’s report, whereas it increased in all of the groups in the parents’ report. Increases in QoL scores were associated with an increase in height SDS. <b><i>Conclusions:</i></b> Treatment with GH and AI/GH was associated with improved QoL scores as measured from both the patients’ and the parents’ perspectives, suggesting that the improved growth resulting from the use of these growth-promoting therapies has beneficial psychosocial effects in adolescent males with ISS followed for 24 months.
DOI: 10.6084/m9.figshare.7783991.v2
title: ColPortal_miRNA_rawData

description: Metadata for joining raw from Human miRNA Microarray Kit (V3), 8x15K (Agilent) with clinical cases<br>
DOI: 10.6084/m9.figshare.7783976
title: test-molecule.sdf

description: test SD file
DOI: 10.6084/m9.figshare.7783991.v1
title: ColPortal_miRNA_rawData

description: Metadata for joining raw from Human miRNA Microarray Kit (V3), 8x15K (Agilent) with clinical cases<br>
DOI: 10.6084/m9.figshare.7783976.v1
title: test-molecule.sdf

description: test SD file
DOI: 10.6084/m9.figshare.7783532
title: ColPortal_expressionRNA_rawData

description: Metadata for joining raw from Ag_Hsa_GE_G4112F_014850_4x44K (Agilent) with clinical cases<br>
DOI: 10.6084/m9.figshare.7783508
title: Supplementary Material for: Fibroblast Growth Factor 23 Trajectories in Chronic Hemodialysis Patients: Lessons from the HEMO Study

description: <b><i>Background:</i></b> Long-term patterns of fibroblast growth factor 23 (FGF23) are poorly characterized among dialysis patients. <b><i>Objectives:</i></b> To identify different FGF23 trajectories and determine clinical factors that predict distinct FGF23 trajectories and whether FGF23 trajectories differ in regard to their associations with all-cause mortality among prevalent hemodialysis patients. <b><i>Methods:</i></b> The HEMO study was a randomized multicenter study evaluating the effects of high-dose vs. standard-dose and high-flux vs. low-flux hemodialysis on mortality. We measured intact FGF23 levels in stored serum samples at baseline and annually among 919 HEMO participants and identified FGF23 trajectories using group-based modeling. Logistic regression determined predictors of trajectories. Cox regression models evaluated the association between trajectory and all-cause mortality. <b><i>Results:</i></b> We identified 5 distinct FGF23 trajectory groups during the initial 24 months: low stable, low increasing, elevated increasing, elevated decreasing, and elevated stable. In multivariable models, diabetes, high dose dialysis, no venous catheter, low serum calcium, phosphorus, and interleukin-6, no vitamin D analog use, and greater residual kidney function were associated with the low stable trajectory group compared to the elevated stable group. High flux dialysis, no venous catheter, and low serum phosphorus and 25-hydroxyvitamin D were associated with the elevated decreasing trajectory group compared to the elevated stable group. After full adjustment, the low stable trajectory group was associated with reduced mortality (hazard ratio [HR] 0.61; 95% CI ­0.41–0.91) compared to the elevated stable trajectory group. <b><i>Conclusions:</i></b> We identified 5 distinct FGF23 trajectories over 24 months among HEMO study participants including a decreasing trajectory. The low stable FGF23 trajectory was associated with a reduced HR of all-cause mortality.
DOI: 10.6084/m9.figshare.7783532.v1
title: ColPortal_expressionRNA_rawData

description: Metadata for joining raw from Ag_Hsa_GE_G4112F_014850_4x44K (Agilent) with clinical cases<br>
DOI: 10.6084/m9.figshare.7783358
title: What does Brexit mean to you in three words?

description: From September until December 2018, LSE Library held an exhibition of its archives relating to the history of the UK in and out of the EU called "What does Brexit mean to you?" The exhibition was free, unticketed and open to all, and housed right by the entrance to the Library. <br><br>On one of the walls of the exhibition, the question "What does Brexit mean to you in three words?" was printed on a large poster, and visitors were invited to write their responses using post-it notes and stick them to the wall.<br><br>This spreadsheet is a transcription of 664 of those post-it notes. Some changes to spelling/grammar have been made and changed into lowercase. The transcription was not conducted as a full-scale research project but rather as a record of audience participation in an exhibition, so this should be borne in mind when using this spreadsheet. There is no significance to the running number order - each post-it note was assigned a random number when being transcribed. It is possible one person filled out multiple post-it notes so it does not necessarily represent 664 individuals. The original post-it notes are held at LSE Library and are available for consultation there.
DOI: 10.6084/m9.figshare.7783355
title: sample.json

description: test description
DOI: 10.6084/m9.figshare.7783355.v1
title: sample.json

description: test description
DOI: 10.6084/m9.figshare.7783106
title: Tables S1 to S4 from Ancestral and offspring nutrition interact to affect life-history traits in <i>Drosophila melanogaster</i>

description: Included in file
DOI: 10.6084/m9.figshare.7783106.v1
title: Tables S1 to S4 from Ancestral and offspring nutrition interact to affect life-history traits in <i>Drosophila melanogaster</i>

description: Included in file
DOI: 10.6084/m9.figshare.7782947
title: ColPortal_methylation_rawData

description: Metadata for joining raw from HumanMethylation450K BeadChip (Illumina, Inc., San Diego, CA) with clinical cases
DOI: 10.6084/m9.figshare.7782947.v1
title: ColPortal_methylation_rawData

description: Metadata for joining raw from HumanMethylation450K BeadChip (Illumina, Inc., San Diego, CA) with clinical cases
DOI: 10.6084/m9.figshare.7782734
title: #memyselfandI - Content Analysis of Impression Management Strategies of German Lifestyle Influencer

description: Master Table: Content Analysis of Impression Management Strategies of German Influencer
DOI: 10.6084/m9.figshare.7782737
title: Interactions BridgeDb ID Mapping Database (20190228)

description: BridgeDb ID mapping database for interactions, using Rhea (version 101, 2019-02-15) as data source.<br>Several updated mappings compared to release of 2018-08-22.
DOI: 10.6084/m9.figshare.7782737.v1
title: Interactions BridgeDb ID Mapping Database (20190228)

description: BridgeDb ID mapping database for interactions, using Rhea (version 101, 2019-02-15) as data source.<br>Several updated mappings compared to release of 2018-08-22.<br>NEW WikiPathways pathways annotated with Rhea:
DOI: 10.6084/m9.figshare.7782596
title: Economic and quality of life burden of anemia on patients with CKD on dialysis: a systematic review

description: <b>Aims:</b> The overall cost and health-related quality of life (HRQoL) associated with current treatments for chronic kidney disease (CKD)-related anemia are not well characterized. A systematic literature review (SLR) was conducted on the costs and HRQoL associated with current treatments for CKD-related anemia among dialysis-dependent (DD) patients. <b>Materials and methods:</b> The authors searched the Cochrane Library, MEDLINE, EMBASE, NHS EED, and NHS HTA for English-language publications. Original studies published between January 1, 2000 and March 17, 2017 meeting the following criteria were included: adult population; study focus was CKD-related anemia; included results on patients receiving iron supplementation, red blood cell transfusion, or erythropoiesis stimulating agents (ESAs); reported results on HRQoL and/or costs. Studies which included patients with DD-CKD, did not directly compare different treatments, and had designs relevant to the objective were retained. HRQoL and cost outcomes, including healthcare resource utilization (HRU), were extracted and summarized in a narrative synthesis. <b>Results:</b> A total of 1,625 publications were retrieved, 15 of which met all inclusion criteria. All identified studies included ESAs as a treatment of interest. Two randomized controlled trials reported that ESA treatment improves HRQoL relative to placebo. Across eight studies comparing HRQoL of patients achieving high vs low hemoglobin (Hb) targets, aiming for higher Hb targets with ESAs generally led to modest HRQoL improvements. Two studies reported that ESA-treated patients had lower costs and HRU compared to untreated patients. One study found that aiming for higher vs lower Hb targets led to reduced HRU, while two other reported that this led to a reduction in cost-effectiveness. <b>Limitations:</b> Heterogeneity of study designs and outcomes; a meta-analysis could not be performed. <b>Conclusions:</b> ESA-treated patients undergoing dialysis incurred lower costs, lower HRU, and had better HRQoL relative to ESA-untreated patients. However, treatment to higher Hb targets led to modest HRQoL improvements compared to lower Hb targets.
DOI: 10.6084/m9.figshare.7782638
title: Supplementary Material for: Genetic Content of the Neo-Sex Chromosomes in Ctenonotus and Norops (Squamata, Dactyloidae) and Degeneration of the Y Chromosome as Revealed by High-Throughput Sequencing of Individual Chromosomes

description: Pleurodont lizards are characterized by an ancient system of sex chromosomes. Along with stability of the central component of the system (homologous to the X chromosome of <i>Anolis carolinensis </i>[Dactyloidae], ACAX), in some genera the ancestral sex chromosomes are fused with microautosomes, forming neo-sex chromosomes. The genus <i>Ctenonotus </i>(Dactyloidae) is characterized by multiple X<sub>1</sub>X<sub>1</sub>X<sub>2</sub>X<sub>2</sub>/X<sub>1</sub>X<sub>2</sub>Y sex chromosomes. According to cytogenetic data, the large neo-Y chromosome is formed by fusion of the ancestral Y chromosome with 2 microautosomes (homologous to ACA10 or ACA11 and ACA12), the X<sub>1</sub> chromosome is formed by fusion of the ancestral X chromosome with the autosome homologous to ACA10 or ACA11, and the X<sub>2</sub> chromosome is homologous to autosome ACA12. To determine more precisely the content and evolution of the <i>Ctenonotus</i> sex chromosomes, we sequenced flow-sorted chromosomes (both sex chromosomes and microautosomes as control) of 2 species with a similar system: <i>C. pogus</i> and <i>C. sabanus</i>. Our results indicate that the translocated part of the X<sub>1</sub> is homologous to ACA11, X<sub>2</sub> is homologous to ACA12, and the Y contains segments homologous to both ACA11 and ACA12. Molecular divergence estimates suggest that the ancestral X-derived part has completely degenerated in the Y of <i>Ctenonotus</i>, similar to the degeneration of the <i>Norops sagrei </i>Y chromosome (Dactyloidae). The newly added regions show loss of DNA content, but without degeneration of the conserved regions. We hypothesize that the translocation of autosomal blocks onto sex chromosomes facilitated rapid degeneration of the pseudoautosomal region on the ancestral Y.
DOI: 10.6084/m9.figshare.7782638.v1
title: Supplementary Material for: Genetic Content of the Neo-Sex Chromosomes in Ctenonotus and Norops (Squamata, Dactyloidae) and Degeneration of the Y Chromosome as Revealed by High-Throughput Sequencing of Individual Chromosomes

description: Pleurodont lizards are characterized by an ancient system of sex chromosomes. Along with stability of the central component of the system (homologous to the X chromosome of <i>Anolis carolinensis </i>[Dactyloidae], ACAX), in some genera the ancestral sex chromosomes are fused with microautosomes, forming neo-sex chromosomes. The genus <i>Ctenonotus </i>(Dactyloidae) is characterized by multiple X<sub>1</sub>X<sub>1</sub>X<sub>2</sub>X<sub>2</sub>/X<sub>1</sub>X<sub>2</sub>Y sex chromosomes. According to cytogenetic data, the large neo-Y chromosome is formed by fusion of the ancestral Y chromosome with 2 microautosomes (homologous to ACA10 or ACA11 and ACA12), the X<sub>1</sub> chromosome is formed by fusion of the ancestral X chromosome with the autosome homologous to ACA10 or ACA11, and the X<sub>2</sub> chromosome is homologous to autosome ACA12. To determine more precisely the content and evolution of the <i>Ctenonotus</i> sex chromosomes, we sequenced flow-sorted chromosomes (both sex chromosomes and microautosomes as control) of 2 species with a similar system: <i>C. pogus</i> and <i>C. sabanus</i>. Our results indicate that the translocated part of the X<sub>1</sub> is homologous to ACA11, X<sub>2</sub> is homologous to ACA12, and the Y contains segments homologous to both ACA11 and ACA12. Molecular divergence estimates suggest that the ancestral X-derived part has completely degenerated in the Y of <i>Ctenonotus</i>, similar to the degeneration of the <i>Norops sagrei </i>Y chromosome (Dactyloidae). The newly added regions show loss of DNA content, but without degeneration of the conserved regions. We hypothesize that the translocation of autosomal blocks onto sex chromosomes facilitated rapid degeneration of the pseudoautosomal region on the ancestral Y.
DOI: 10.6084/m9.figshare.7782596.v1
title: Economic and quality of life burden of anemia on patients with CKD on dialysis: a systematic review

description: <b>Aims:</b> The overall cost and health-related quality of life (HRQoL) associated with current treatments for chronic kidney disease (CKD)-related anemia are not well characterized. A systematic literature review (SLR) was conducted on the costs and HRQoL associated with current treatments for CKD-related anemia among dialysis-dependent (DD) patients. <b>Materials and methods:</b> The authors searched the Cochrane Library, MEDLINE, EMBASE, NHS EED, and NHS HTA for English-language publications. Original studies published between January 1, 2000 and March 17, 2017 meeting the following criteria were included: adult population; study focus was CKD-related anemia; included results on patients receiving iron supplementation, red blood cell transfusion, or erythropoiesis stimulating agents (ESAs); reported results on HRQoL and/or costs. Studies which included patients with DD-CKD, did not directly compare different treatments, and had designs relevant to the objective were retained. HRQoL and cost outcomes, including healthcare resource utilization (HRU), were extracted and summarized in a narrative synthesis. <b>Results:</b> A total of 1,625 publications were retrieved, 15 of which met all inclusion criteria. All identified studies included ESAs as a treatment of interest. Two randomized controlled trials reported that ESA treatment improves HRQoL relative to placebo. Across eight studies comparing HRQoL of patients achieving high vs low hemoglobin (Hb) targets, aiming for higher Hb targets with ESAs generally led to modest HRQoL improvements. Two studies reported that ESA-treated patients had lower costs and HRU compared to untreated patients. One study found that aiming for higher vs lower Hb targets led to reduced HRU, while two other reported that this led to a reduction in cost-effectiveness. <b>Limitations:</b> Heterogeneity of study designs and outcomes; a meta-analysis could not be performed. <b>Conclusions:</b> ESA-treated patients undergoing dialysis incurred lower costs, lower HRU, and had better HRQoL relative to ESA-untreated patients. However, treatment to higher Hb targets led to modest HRQoL improvements compared to lower Hb targets.
DOI: 10.6084/m9.figshare.7782566
title: data20190228.pdf

description: Impact of Palliative Chemotherapy and Best Supportive Care on Overall Survival and Length of Hospitalization in Patients with Incurable Cancer: A 4-Year Single Institution Experience in JapanThe determinants for treatment choice were age, ECOG PS and type of cancer, not sex difference. Oncologists should explain to patients that OS and the length of hospitalization vary according to the ECOG PS when selecting between palliative chemotherapy and BSC.<b></b><i></i><sub></sub><sup></sup><br><b></b><i></i><sub></sub><sup></sup><br>
DOI: 10.6084/m9.figshare.7782563
title: Additional file 9: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S8. Thao HLA-A*, B* and DRB1* alleles, haplotype linkage, and three loci haplotype frequencies in all populations. (XLSX 183 kb)
DOI: 10.6084/m9.figshare.7782563.v1
title: Additional file 9: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S8. Thao HLA-A*, B* and DRB1* alleles, haplotype linkage, and three loci haplotype frequencies in all populations. (XLSX 183 kb)
DOI: 10.6084/m9.figshare.7782557
title: Additional file 7: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S5. F4b phylogenetic tree. (XLS 494 kb)
DOI: 10.6084/m9.figshare.7782554
title: Additional file 6: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S4. F1a3 phylogenetic tree. (XLS 502 kb)
DOI: 10.6084/m9.figshare.7782551
title: Additional file 5: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S3. B5a2a phylogenetic tree. (XLS 502 kb)
DOI: 10.6084/m9.figshare.7782554.v1
title: Additional file 6: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S4. F1a3 phylogenetic tree. (XLS 502 kb)
DOI: 10.6084/m9.figshare.7782548
title: Additional file 4: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S2. B4b1a2 phylogenetic tree. (XLS 502 kb)
DOI: 10.6084/m9.figshare.7782551.v1
title: Additional file 5: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S3. B5a2a phylogenetic tree. (XLS 502 kb)
DOI: 10.6084/m9.figshare.7782557.v1
title: Additional file 7: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S5. F4b phylogenetic tree. (XLS 494 kb)
DOI: 10.6084/m9.figshare.7782539
title: Additional file 2: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S9. Neutrality tests in all populations. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7782548.v1
title: Additional file 4: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S2. B4b1a2 phylogenetic tree. (XLS 502 kb)
DOI: 10.6084/m9.figshare.7782533
title: Additional file 1: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S1. Frequencies of all gene systems. (XLS 546 kb)
DOI: 10.6084/m9.figshare.7782539.v1
title: Additional file 2: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S9. Neutrality tests in all populations. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.7782527
title: Additional file 3: of Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1Â month

description: Data files. (ZIP 65 kb)
DOI: 10.6084/m9.figshare.7782530
title: Additional file 11: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S7. Partial and complete mtDNA genome(raw data). (XLSX 92 kb)
DOI: 10.6084/m9.figshare.7782533.v1
title: Additional file 1: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S1. Frequencies of all gene systems. (XLS 546 kb)
DOI: 10.6084/m9.figshare.7782521
title: Additional file 2: of Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1Â month

description: Sample R script and Stata syntax for unadjusted analyses. (ZIP 8 kb)
DOI: 10.6084/m9.figshare.7782524
title: Additional file 10: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S6. Thao NRY SNPs and STRs. (XLS 525 kb)
DOI: 10.6084/m9.figshare.7782527.v1
title: Additional file 3: of Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1Â month

description: Data files. (ZIP 65 kb)
DOI: 10.6084/m9.figshare.7782530.v1
title: Additional file 11: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S7. Partial and complete mtDNA genome(raw data). (XLSX 92 kb)
DOI: 10.6084/m9.figshare.7782521.v1
title: Additional file 2: of Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1Â month

description: Sample R script and Stata syntax for unadjusted analyses. (ZIP 8 kb)
DOI: 10.6084/m9.figshare.7782524.v1
title: Additional file 10: of Genetic diversity of the Thao people of Taiwan using Y-chromosome, mitochondrial DNA and HLA gene systems

description: Table S6. Thao NRY SNPs and STRs. (XLS 525 kb)
DOI: 10.6084/m9.figshare.7782506
title: Additional file 7: of Flax (Linum usitatissimum L.) response to non-optimal soil acidity and zinc deficiency

description: Gene expression alterations in flax cultivar Norlin under Zn deficiency and pHâ 7.5. (XLSX 6580 kb)
DOI: 10.6084/m9.figshare.7782512
title: Additional file 9: of Flax (Linum usitatissimum L.) response to non-optimal soil acidity and zinc deficiency

description: GO enrichment analysis for tops of up- and down-regulated genes in flax cultivar Mogilevsky under Zn deficiency. (XLSX 10861 kb)
DOI: 10.6084/m9.figshare.7782506.v1
title: Additional file 7: of Flax (Linum usitatissimum L.) response to non-optimal soil acidity and zinc deficiency

description: Gene expression alterations in flax cultivar Norlin under Zn deficiency and pHâ 7.5. (XLSX 6580 kb)
DOI: 10.6084/m9.figshare.7782512.v1
title: Additional file 9: of Flax (Linum usitatissimum L.) response to non-optimal soil acidity and zinc deficiency

description: GO enrichment analysis for tops of up- and down-regulated genes in flax cultivar Mogilevsky under Zn deficiency. (XLSX 10861 kb)
DOI: 10.6084/m9.figshare.7782497
title: Additional file 6: of Flax (Linum usitatissimum L.) response to non-optimal soil acidity and zinc deficiency

description: Gene expression alterations in flax cultivar Mogilevsky under Zn deficiency and pHâ 7.5. (XLSX 6727 kb)
DOI: 10.6084/m9.figshare.7782491
title: Additional file 5: of Flax (Linum usitatissimum L.) response to non-optimal soil acidity and zinc deficiency

description: Gene expression alterations in flax cultivar Norlin under pHâ 7.5. (XLSX 6700 kb)