cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19944546.v1
title: Microbial rhizosphere communities in response to chlorimuron-ethyl herbicide in soils under alfafa crop

description: ABSTRACT Biolog Eco technology was used to investigate the effects of different chemical herbicide application methods, such as pre-emergence after sowing and post-emergence (stem and leaf spraying), on the characteristics of carbon source utilization by microbial communities in alfalfa rhizosphere soil. The averages of well color development (AWCD) and microbial metabolism diversity indices of post-emergence herbicide spraying on stems and leaves were significantly lower than those of pre-emergence herbicide and without herbicide treatments. Furthermore, pre-emergence after sowing herbicide treatment did not affect soil microorganisms. The principal component analysis (PCA) revealed that the microbial community diversities of the rhizosphere soils differed significantly between herbicide treatments. Carbohydrate was the carbon source type that was most sensitive to herbicide treatment changes, followed by amino acids and carboxylic acids. The herbicide application method significantly reduced the capacities of the microbial community to utilize the carbon sources, as mainly manifested in the ability to use polymers. As shown by a comprehensive analysis on the growth of alfalfa and the physiological and biochemical indices of its root system, the application of herbicide chlorimuron-ethyl reduced the alfalfa yield, and the two different application methods tested showed no significant difference. Herbicide application and different application methods showed significant impacts on alfalfa root activity and membrane permeability, suggesting that the application of herbicide damaged the membrane permeability and the activity of the alfalfa root system. Impacts of herbicide residues in the soil after stem and leaf post-emergence treatment on alfalfa growth and soil microorganisms should not be ignored.
DOI: 10.24403/jp.1339427
title: Balandin, S.A., Gubanov, I.A., Jarvis, C.E., Majorov, S.R., Simonov, S.S, Sokoloff, D.D., Sukhov, S.V.: The Linnaean Collection of the Herbarium of Moscow State University: digital images, comments, historical review. Moscow : Dehlia Co., 2001 / [rezensiert von] Volker Wissemann
DOI: 10.6084/m9.figshare.24138852
title: A literature-based methane exchange dataset on the Qinghai-Tibetan Plateau

description: Observations of CH4 fluxes from 27 sites across the wetland and grassland on the QTP.
DOI: 10.6084/m9.figshare.14177448
title: Cholinesterase homozygous genotype as susceptible biomarker of hypertriglyceridaemia for pesticide-exposed agricultural workers

description: Dyslipidemia is an emerging metabolic disorder among pesticide-exposed agricultural workers, and this study was aimed to explore biomarkers of hypertriglyceridaemia susceptibility. This cross-sectional study recruited 72 pesticide-exposed subjects and 78 non-exposed controls. Lipid profile, cholinesterase activity, and thyroid hormones were analysed with routine assays. Six loci, including rs11206244 and rs2235544 for deiodinase 1, rs12885300 and rs225014 for deiodinase 2, rs1803274 for butyrylcholinesterase, and rs3757869 for acetylcholinesterase were genotyped using an improved multiplex ligation detection reaction technique. Pesticide-exposed subjects showed higher levels of triglyceride than controls (<i>p</i> = 0.009), although there were comparable cholinesterase activity and genotype frequencies of all six loci between pesticide-exposed subjects and controls. Pesticide-exposed subjects with homozygous genotype of cholinesterase had increased triglyceride levels than controls (<i>p</i> &lt; 0.05). The percentage of hypertriglyceridaemia was 28.6% and 8.8% for pesticide-exposed subjects and controls with homozygous butyrylcholinesterase genotype (<i>p</i> = 0.007) and 20.8% and 14.3% with homozygous acetylcholinesterase genotype (<i>p</i> = 0.792), respectively. Multivariate logistic regression analyses found that odds ratio of hypertriglyceridaemia is 21.92 and 4.56 for pesticide-exposed subjects with homozygous genotype of butyrylcholinesterase (<i>p</i> = 0.001) and acetylcholinesterase (<i>p</i> = 0.036), respectively. Cholinesterase homozygous genotype might be a potential susceptible biomarker in screening pesticide-exposed agricultural workers vulnerable to hypertriglyceridaemia.
DOI: 10.6084/m9.figshare.14177448.v1
title: Cholinesterase homozygous genotype as susceptible biomarker of hypertriglyceridaemia for pesticide-exposed agricultural workers

description: Dyslipidemia is an emerging metabolic disorder among pesticide-exposed agricultural workers, and this study was aimed to explore biomarkers of hypertriglyceridaemia susceptibility. This cross-sectional study recruited 72 pesticide-exposed subjects and 78 non-exposed controls. Lipid profile, cholinesterase activity, and thyroid hormones were analysed with routine assays. Six loci, including rs11206244 and rs2235544 for deiodinase 1, rs12885300 and rs225014 for deiodinase 2, rs1803274 for butyrylcholinesterase, and rs3757869 for acetylcholinesterase were genotyped using an improved multiplex ligation detection reaction technique. Pesticide-exposed subjects showed higher levels of triglyceride than controls (<i>p</i> = 0.009), although there were comparable cholinesterase activity and genotype frequencies of all six loci between pesticide-exposed subjects and controls. Pesticide-exposed subjects with homozygous genotype of cholinesterase had increased triglyceride levels than controls (<i>p</i> &lt; 0.05). The percentage of hypertriglyceridaemia was 28.6% and 8.8% for pesticide-exposed subjects and controls with homozygous butyrylcholinesterase genotype (<i>p</i> = 0.007) and 20.8% and 14.3% with homozygous acetylcholinesterase genotype (<i>p</i> = 0.792), respectively. Multivariate logistic regression analyses found that odds ratio of hypertriglyceridaemia is 21.92 and 4.56 for pesticide-exposed subjects with homozygous genotype of butyrylcholinesterase (<i>p</i> = 0.001) and acetylcholinesterase (<i>p</i> = 0.036), respectively. Cholinesterase homozygous genotype might be a potential susceptible biomarker in screening pesticide-exposed agricultural workers vulnerable to hypertriglyceridaemia.
DOI: 10.6084/m9.figshare.21517527
title: Research on infrared dim and small target detection algorithm based on local contrast and gradient

description: The rapid development of infrared technology makes it widely applicable in such fields as military, medical, testing and communications.This paper proposes an algorithm based on local contrast and gradient (LCG). Specifically, the algorithm uses the difference of gaussian and threshold segmentation to preprocess to obtain the position of possible target points. Then, local contrast processing is conducted for the possible target points. Finally, the global is processed using an improved directional gradient. According to the experimental results, the proposed algorithm outperforms the existing algorithms in terms of detection probability and false detection probability.
DOI: 10.6084/m9.figshare.21517527.v1
title: Research on infrared dim and small target detection algorithm based on local contrast and gradient

description: The rapid development of infrared technology makes it widely applicable in such fields as military, medical, testing and communications.This paper proposes an algorithm based on local contrast and gradient (LCG). Specifically, the algorithm uses the difference of gaussian and threshold segmentation to preprocess to obtain the position of possible target points. Then, local contrast processing is conducted for the possible target points. Finally, the global is processed using an improved directional gradient. According to the experimental results, the proposed algorithm outperforms the existing algorithms in terms of detection probability and false detection probability.
DOI: 10.6084/m9.figshare.23090394
title: O1-conotoxin Tx6.7 cloned from the genomic DNA of Conus textile that inhibits calcium currents

description: Abstract Background: Conotoxins exhibit great potential as neuropharmacology tools and therapeutic candidates due to their high affinity and specificity for ion channels, neurotransmitter receptors or transporters. The traditional methods to discover new conotoxins are peptide purification from the crude venom or gene amplification from the venom duct. Methods: In this study, a novel O1 superfamily conotoxin Tx6.7 was directly cloned from the genomic DNA of Conus textile using primers corresponding to the conserved intronic sequence and 3’ UTR elements. The mature peptide of Tx6.7 (DCHERWDWCPASLLGVIYCCEGLICFIAFCI) was synthesized by solid-phase chemical synthesis and confirmed by mass spectrometry. Results: Patch clamp experiments on rat DRG neurons showed that Tx6.7 inhibited peak calcium currents by 59.29 ± 2.34% and peak potassium currents by 22.33 ± 7.81%. In addition, patch clamp on the ion channel subtypes showed that 10 μM Tx6.7 inhibited 56.61 ± 3.20% of the hCaV1.2 currents, 24.67 ± 0.91% of the hCaV2.2 currents and 7.30 ± 3.38% of the hNaV1.8 currents. Tx6.7 had no significant toxicity to ND7/23 cells and increased the pain threshold from 0.5 to 4 hours in the mouse hot plate assay. Conclusion: Our results suggested that direct cloning of conotoxin sequences from the genomic DNA of cone snails would be an alternative approach to obtaining novel conotoxins. Tx6.7 could be used as a probe tool for ion channel research or a therapeutic candidate for novel drug development.
DOI: 10.6084/m9.figshare.23090394.v1
title: O1-conotoxin Tx6.7 cloned from the genomic DNA of Conus textile that inhibits calcium currents

description: Abstract Background: Conotoxins exhibit great potential as neuropharmacology tools and therapeutic candidates due to their high affinity and specificity for ion channels, neurotransmitter receptors or transporters. The traditional methods to discover new conotoxins are peptide purification from the crude venom or gene amplification from the venom duct. Methods: In this study, a novel O1 superfamily conotoxin Tx6.7 was directly cloned from the genomic DNA of Conus textile using primers corresponding to the conserved intronic sequence and 3’ UTR elements. The mature peptide of Tx6.7 (DCHERWDWCPASLLGVIYCCEGLICFIAFCI) was synthesized by solid-phase chemical synthesis and confirmed by mass spectrometry. Results: Patch clamp experiments on rat DRG neurons showed that Tx6.7 inhibited peak calcium currents by 59.29 ± 2.34% and peak potassium currents by 22.33 ± 7.81%. In addition, patch clamp on the ion channel subtypes showed that 10 μM Tx6.7 inhibited 56.61 ± 3.20% of the hCaV1.2 currents, 24.67 ± 0.91% of the hCaV2.2 currents and 7.30 ± 3.38% of the hNaV1.8 currents. Tx6.7 had no significant toxicity to ND7/23 cells and increased the pain threshold from 0.5 to 4 hours in the mouse hot plate assay. Conclusion: Our results suggested that direct cloning of conotoxin sequences from the genomic DNA of cone snails would be an alternative approach to obtaining novel conotoxins. Tx6.7 could be used as a probe tool for ion channel research or a therapeutic candidate for novel drug development.
DOI: 10.6084/m9.figshare.11556153
title: Data from Numerical simulation on fracturing behaviour of hard roofs at different levels during extra-thick coal seam mining.

description: Data supported the article
DOI: 10.6084/m9.figshare.11556153.v2
title: Data from Numerical simulation on fracturing behaviour of hard roofs at different levels during extra-thick coal seam mining.

description: Data supported the article
DOI: 10.5281/zenodo.10622938
title: International Human Rights Law in Israeli Courts

description: This dataset was created by Natalie R. Davidson and Tamar Hostovsky Brandes with the assistance of Matar Ben Ishai and Gilad Mor. It contains two files, both in Hebrew. 

The first, "IHRL in Israeli Courts", is a database of all Israeli court decisions between 1990 and 2019 referring to International Human Rights Law (the sources listed in the Key spreadsheet). Each decision is coded for a long list of attributes detailed in the Key spreadhseet. The general database with all decisions appears in the "United" spreadsheet. The file also contains a spreadsheet focusing on criminal cases only (Criminal), family law cases only (Family), and all cases other than family law cases (NoFamily)

The second file, "IHRL in Israeli Courts - European Convention Law only" contains only those decisions from the general database that refer to the European Convention on Human Rights, the jurisprudence of the European Court of Human Rights and/or the jurisprudence of the European Commission on Human Rights.

For inquiries please contact davidson@tauex.tau.ac.il or tamar_brandes@ono.ac.il
DOI: 10.5281/zenodo.10622939
title: International Human Rights Law in Israeli Courts

description: This dataset was created by Natalie R. Davidson and Tamar Hostovsky Brandes with the assistance of Matar Ben Ishai and Gilad Mor. It contains two files, both in Hebrew. 

The first, "IHRL in Israeli Courts", is a database of all Israeli court decisions between 1990 and 2019 referring to International Human Rights Law (the sources listed in the Key spreadsheet). Each decision is coded for a long list of attributes detailed in the Key spreadhseet. The general database with all decisions appears in the "United" spreadsheet. The file also contains a spreadsheet focusing on criminal cases only (Criminal), family law cases only (Family), and all cases other than family law cases (NoFamily)

The second file, "IHRL in Israeli Courts - European Convention Law only" contains only those decisions from the general database that refer to the European Convention on Human Rights, the jurisprudence of the European Court of Human Rights and/or the jurisprudence of the European Commission on Human Rights.

For inquiries please contact davidson@tauex.tau.ac.il or tamar_brandes@ono.ac.il
DOI: 10.6084/m9.figshare.19944822
title: Ratanasampil is more effective than flunarizine in relieving migraine

description: <b>Aims:</b> Migraine is a common neurological disorder with high incidence in population. This study aimed to investigate the therapeutic efficacy of Tibetan medicine Ratanasampil (RNSP) and to identify the serum biomarkers for diagnosis and response assessment.<b>Materials and methods</b>: We prospectively recruited 108 migraine patients living at high altitude (2,260 m), including 40 patients for RNSP group, 40 patients for flunarizine (FLZ) group, and 28 patients for placebo group. Serum levels of 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), calcitonin gene related peptide (CGRP), nerve growth factor (NGF) and β-endorphin (β-EP) before and after therapy were measured.<b>Results:</b> In comparison with placebo, both FLZ and RNSP significantly reduced the migraine days, HIT-6 score and verbal rating scale, headache intensity, duration, accompanying symptoms and headache score in four and eight weeks treatment. RNSP showed no significant difference to FLZ in the above parameters after four weeks treatment, but showed significantly better relief after eight weeks treatment. The overall effective rate of RNSP (92.5%) was also significantly higher than FLZ (74.4%, p &lt; 0.05), mainly due to significantly higher ratio of patients with full recovery. The serum levels of biomarkers, including 5-HT, BDNF, NGF and β-EP, significantly elevated after eight weeks of treatment with RNSP, whereas the level of CGRP significantly decreased. The serum level of 5-HT exhibited significantly bigger percentage changes than other markers.<b>Conclusion:</b> In conclusion, RNSP was more effective than FLZ in relieving migraine after eight weeks continuous treatment. Serum 5-HT, BDNF, CGRP, NGF and β-EP were effective markers reflecting the response to RNSP and FLZ therapy.
DOI: 10.6084/m9.figshare.19944822.v1
title: Ratanasampil is more effective than flunarizine in relieving migraine

description: <b>Aims:</b> Migraine is a common neurological disorder with high incidence in population. This study aimed to investigate the therapeutic efficacy of Tibetan medicine Ratanasampil (RNSP) and to identify the serum biomarkers for diagnosis and response assessment.<b>Materials and methods</b>: We prospectively recruited 108 migraine patients living at high altitude (2,260 m), including 40 patients for RNSP group, 40 patients for flunarizine (FLZ) group, and 28 patients for placebo group. Serum levels of 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), calcitonin gene related peptide (CGRP), nerve growth factor (NGF) and β-endorphin (β-EP) before and after therapy were measured.<b>Results:</b> In comparison with placebo, both FLZ and RNSP significantly reduced the migraine days, HIT-6 score and verbal rating scale, headache intensity, duration, accompanying symptoms and headache score in four and eight weeks treatment. RNSP showed no significant difference to FLZ in the above parameters after four weeks treatment, but showed significantly better relief after eight weeks treatment. The overall effective rate of RNSP (92.5%) was also significantly higher than FLZ (74.4%, p &lt; 0.05), mainly due to significantly higher ratio of patients with full recovery. The serum levels of biomarkers, including 5-HT, BDNF, NGF and β-EP, significantly elevated after eight weeks of treatment with RNSP, whereas the level of CGRP significantly decreased. The serum level of 5-HT exhibited significantly bigger percentage changes than other markers.<b>Conclusion:</b> In conclusion, RNSP was more effective than FLZ in relieving migraine after eight weeks continuous treatment. Serum 5-HT, BDNF, CGRP, NGF and β-EP were effective markers reflecting the response to RNSP and FLZ therapy.
DOI: 10.6084/m9.figshare.6837740
title: Genetic and structural characterization of 20 autosomal short tandem repeats in the Chinese Qinghai Han population and its genetic relationships and interpopulation differentiations with other reference populations

description: China is a multinational country composed of 56 ethnic groups of which the Han Chinese accounts for 91.60%. Qinghai Province is located in the northeastern part of the Qinghai–Tibet Plateau, has an area of 72.12 km<sup>2</sup>, and is the fourth largest province in China. In the present study, we investigated the genetic polymorphisms of 20 short tandem repeat (STR) loci in a Qinghai Han population, as well as its genetic relationships with other populations. A total of 273 alleles were identified in 2 000 individuals at 20 loci, and the allelic frequency ranged from 0.000 2 to 0.532 7. The 20 STR loci showed a relatively high polymorphic rate in the studied group. Observed and expected heterozygosities ranged 0.613 0–0.907 5 and 0.614 8–0.920 0, respectively. The combined power of discrimination, and the probability of exclusion in duo and trio cases were 0.999 999 999 999 999 999 999 999 34, 0.999 996 0 and 0.999 999 996 5, respectively. Analyses of interpopulation differentiation revealed that the most significant differences were found between the Qinghai Han and Malaysian, while no significant differences were found between the Qinghai Han and Han people from Shaanxi and Jiangsu. The results of principal component analysis, multidimensional scaling analysis and phylogenetic reconstructions also suggested the close relationships between the Qinghai Han and other two Han populations. The present results, therefore, indicated that these 20 STR loci could be used for paternity testing and individual identification in forensic applications, and may also provide information for the studies of genetic relationships between Qinghai Han and other groups.
DOI: 10.6084/m9.figshare.6837740.v1
title: Genetic and structural characterization of 20 autosomal short tandem repeats in the Chinese Qinghai Han population and its genetic relationships and interpopulation differentiations with other reference populations

description: China is a multinational country composed of 56 ethnic groups of which the Han Chinese accounts for 91.60%. Qinghai Province is located in the northeastern part of the Qinghai–Tibet Plateau, has an area of 72.12 km<sup>2</sup>, and is the fourth largest province in China. In the present study, we investigated the genetic polymorphisms of 20 short tandem repeat (STR) loci in a Qinghai Han population, as well as its genetic relationships with other populations. A total of 273 alleles were identified in 2 000 individuals at 20 loci, and the allelic frequency ranged from 0.000 2 to 0.532 7. The 20 STR loci showed a relatively high polymorphic rate in the studied group. Observed and expected heterozygosities ranged 0.613 0–0.907 5 and 0.614 8–0.920 0, respectively. The combined power of discrimination, and the probability of exclusion in duo and trio cases were 0.999 999 999 999 999 999 999 999 34, 0.999 996 0 and 0.999 999 996 5, respectively. Analyses of interpopulation differentiation revealed that the most significant differences were found between the Qinghai Han and Malaysian, while no significant differences were found between the Qinghai Han and Han people from Shaanxi and Jiangsu. The results of principal component analysis, multidimensional scaling analysis and phylogenetic reconstructions also suggested the close relationships between the Qinghai Han and other two Han populations. The present results, therefore, indicated that these 20 STR loci could be used for paternity testing and individual identification in forensic applications, and may also provide information for the studies of genetic relationships between Qinghai Han and other groups.
DOI: 10.18419/darus-3242/8
title: SubmapLayoutHelper.java

description: :unav
DOI: 10.6084/m9.figshare.23615119
title: Pan-precancer and cancer DNA methylation profiles revealed significant tissue specificity of interrupted biological processes in tumorigenesis

description: DNA methylation (DNAme) alterations are known to initiate from the precancerous stage of tumorigenesis. Herein, we investigated the global and local patterns of DNAme perturbations in tumorigenesis by analysing the genome-wide DNAme profiles of the cervix, colorectum, stomach, prostate, and liver at precancerous and cancer stages. We observed global hypomethylation in tissues of both two stages, except for the cervix, whose global DNAme level in normal tissue was lower than that of the other four tumour types. For alterations shared by both stages, there were common hyper-methylation (sHyperMethyl) and hypo-methylation (sHypoMethyl) changes, of which the latter type was more frequently identified in all tissues. Biological pathways interrupted by sHyperMethyl and sHypoMethyl alterations demonstrated significant tissue specificity. DNAme bidirectional chaos indicated by the enrichment of both sHyperMethyl and sHypoMethyl changes in the same pathway was observed in most tissues and was a common phenomenon, particularly in liver lesions. Moreover, for the same enriched pathways, different tissues may be affected by distinct DNAme types. For the PI3K−Akt signalling pathway, sHyperMethyl enrichment was observed in the prostate dataset, but sHypoMethyl enrichment was observed in the colorectum and liver datasets. Nevertheless, they did not show an increased possibility in survival prediction of patients in comparison with other DNAme types. Additionally, our study demonstrated that gene-body DNAme changes of tumour suppressor genes and oncogenes may persist from precancerous lesions to the tumour. Overall, we demonstrate the tissue specificity and commonality of cross-stage alterations in DNA methylation profiles in multi-tissue tumorigenesis.