DOI: 10.5061/dryad.0529j
title: Data from: Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella

description: Cilia and flagella are model systems for studying how mechanical forces
 control morphology. The periodic bending motion of cilia and flagella is
 thought to arise from mechanical feedback: dynein motors generate sliding
 forces that bend the flagellum, and bending leads to deformations and
 stresses, which feed back and regulate the motors. Three alternative
 feedback mechanisms have been proposed: regulation by the sliding forces,
 regulation by the curvature of the flagellum, and regulation by the normal
 forces that deform the cross-section of the flagellum. In this work, we
 combined theoretical and experimental approaches to show that the
 curvature control mechanism is the one that accords best with the bending
 waveforms of Chlamydomonas flagella. We make the surprising prediction
 that the motors respond to the time derivative of curvature, rather than
 curvature itself, hinting at an adaptation mechanism controlling the
 flagellar beat.
description: WT Axoneme
 1Movie and waveform of a
 reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type
 cell (CC-125 wild type mt+137c)WT_1.zipWT Axoneme 2Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_2.zipWT Axoneme 3Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_3.zipWT Axoneme 4Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_4.zipWT Axoneme 5Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_5.zipWT Axoneme 6Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_6.zipWT Axoneme 7Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_7.zipWT Axoneme 8Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_8.zipWT Axoneme 9Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_9.zipWT Axoneme 10Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt+137c)WT_10.zipmbo2 Axoneme 1Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_1.zipmbo2 Axoneme 2Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_2.zipmbo2 Axoneme 3Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_3.zipmbo2 Axoneme 4Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_4.zipmbo2 Axoneme 5Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_5.zipmbo2 Axoneme 6Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_6.zipmbo2 Axoneme 7Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_7.zipmbo2 Axoneme 8Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_8.zipmbo2 Axoneme 9Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_9.zipmbo2 Axoneme 10Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii mbo2 mutant cell (CC-2377 mbo2 mt-)mbo2_10.zip