cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7270/q2zs30w1
title: BindingDB Entry 50007838: Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors.

description: Small molecule binding data for protein Capsid protein, Uniprot Q03732
DOI: 10.7270/q2zs30xg
title: BindingDB Entry 50008444: Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor gamma, Uniprot P37231
DOI: 10.7270/q2zs30zx
title: BindingDB Entry 50009096: Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR

description: Small molecule binding data for protein Epidermal growth factor receptor, Uniprot P00533
DOI: 10.7270/q2zs310s
title: BindingDB Entry 50009722: Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.

description: Small molecule binding data for protein Mitogen-activated protein kinase 1 and Mitogen-activated protein kinase 3, Uniprot P27361 and P28482
DOI: 10.7270/q2zs3117
title: BindingDB Entry 50010051: Synthesis and biological evaluation of novel (E)-N'-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors.

description: Small molecule binding data for protein Lysine-specific histone demethylase 1A, Uniprot O60341
DOI: 10.7270/q2zs312p
title: BindingDB Entry 50010304: Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.

description: Small molecule binding data for protein Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A2b, Adenosine receptor A3, Amine oxidase [flavin-containing] A, and Amine oxidase [flavin-containing] B, Uniprot P0DMS8, P21397, P25099, P27338, P29274, P29275, P30542, and P30543
DOI: 10.7270/q2zs3134
title: BindingDB Entry 50010607: Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.

description: Small molecule binding data for protein Glutamate receptor ionotropic, NMDA 2B, Sigma intracellular receptor 2, and Sigma non-opioid intracellular receptor 1, Uniprot Q13224, Q5U3Y7, and Q60492
DOI: 10.7270/q2zs314k
title: BindingDB Entry 50011244: Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.

description: Small molecule binding data for protein Phosphoglycerate mutase 1, Uniprot P18669
DOI: 10.7270/q2zs3151
title: BindingDB Entry 50011871: Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII.

description: Small molecule binding data for protein Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 2, and Carbonic anhydrase 9, Uniprot O43570, P00915, P00918, and Q16790
DOI: 10.7270/q2zs316g
title: BindingDB Entry 50012496: Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M

description: Small molecule binding data for protein Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, and Muscarinic acetylcholine receptor M5, Uniprot P08172, P08173, P08912, P11229, and P20309
DOI: 10.7270/q2zs317x
title: BindingDB Entry 50012832: Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists.

description: Small molecule binding data for protein ATP-dependent translocase ABCB1, Broad substrate specificity ATP-binding cassette transporter ABCG2, and Multidrug resistance-associated protein 1, Uniprot P08183, P33527, and Q9UNQ0
DOI: 10.7270/q2zs318c
title: BindingDB Entry 50013141: Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic.

description: Small molecule binding data for protein Neurotensin receptor type 1 and Neurotensin receptor type 2, Uniprot O88319, O95665, and P30989
DOI: 10.7270/q2zs319t
title: BindingDB Entry 50013484: Discovery of 5-(3-Chlorophenylamino)benzo[

description: Small molecule binding data for protein Aldehyde dehydrogenase 1A1, Casein kinase II subunit alpha 3, and Dual specificity protein kinase CLK2, Uniprot P00352, P49760, and Q8NEV1
DOI: 10.7270/q2zs31b8
title: BindingDB Entry 50014134: Novel Diacylglycerol Acetyltransferase 2 Inhibitors for Treating Liver Diseases.

description: Small molecule binding data for protein Diacylglycerol O-acyltransferase 2, Uniprot Q96PD7
DOI: 10.7270/q2zw1px1
title: BindingDB Entry 9139: Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto

description: Small molecule binding data for protein Prostacyclin receptor, Uniprot P43119
DOI: 10.7270/q2zw1pzg
title: BindingDB Entry 9348: Mammalian and bacterial nitric oxide synthase inhibitors

description: Small molecule binding data for protein Nitric oxide synthase, brain, Nitric oxide synthase, endothelial, and Nitric oxide synthase, inducible, Uniprot P29473, P29474, P29475, P29476, P29477, and Q62600
DOI: 10.7270/q2zw1q0b
title: BindingDB Entry 9526: Inhibitors of integrin alpha 5 beta 1 and methods of use

description: Small molecule binding data for protein Integrin alpha-V/beta-1, Uniprot P05556 and P06756
DOI: 10.7270/q2zw1q1s
title: BindingDB Entry 9735: SHP2 phosphatase inhibitors and methods of use thereof

description: Small molecule binding data for protein SH2B adapter protein 2, Uniprot O14492
DOI: 10.7270/q2zw1q27
title: BindingDB Entry 9913: Cyanopyrrolidine derivatives with activity as inhibitors of USP30

description: Small molecule binding data for protein Ubiquitin carboxyl-terminal hydrolase 30, Uniprot Q70CQ3
DOI: 10.7270/q2zw1q3p
title: BindingDB Entry 10122: Heteroaryl compounds as BTK inhibitors and uses thereof

description: Small molecule binding data for protein Tyrosine-protein kinase BTK, Tyrosine-protein kinase BTK [328-659], and Tyrosine-protein kinase Lck, Uniprot P06239 and Q06187
DOI: 10.7270/q2zw1q44
title: BindingDB Entry 10509: Tricyclic compounds for use in treatment of proliferative disorders

description: Small molecule binding data for protein Methylosome protein 50/Protein arginine N-methyltransferase 5, Uniprot O14744 and Q9BQA1
DOI: 10.7270/q2zw1q5k
title: BindingDB Entry 10896: Quinazolinones that inhibit the formation of tau oligomers and their method of use

description: Small molecule binding data for protein Isoform Tau-F of Microtubule-associated protein tau, Uniprot A0A024RA17 and P10636
DOI: 10.7270/q2zw1q61
title: BindingDB Entry 50007176: Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity.

description: Small molecule binding data for protein Polymerase acidic protein, Uniprot P03433
DOI: 10.7270/q2zw1q7g
title: BindingDB Entry 50007518: Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect.

description: Small molecule binding data for protein Peroxisome proliferator-activated receptor alpha and Peroxisome proliferator-activated receptor gamma, Uniprot P37231 and Q07869
DOI: 10.7270/q2zw1q8x
title: BindingDB Entry 50007792: Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2.

description: Small molecule binding data for protein Histone-lysine N-methyltransferase EHMT1 and Histone-lysine N-methyltransferase EHMT2, Uniprot Q96KQ7 and Q9H9B1
DOI: 10.7270/q2zw1q9c
title: BindingDB Entry 50008122: Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.

description: Small molecule binding data for protein ATP-dependent translocase ABCB1, Broad substrate specificity ATP-binding cassette transporter ABCG2, and Multidrug resistance-associated protein 1, Uniprot P08183, P33527, and Q9UNQ0
DOI: 10.7270/q2zw1qbt
title: BindingDB Entry 50008766: Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.

description: Small molecule binding data for protein Integrase and Reverse transcriptase/RNaseH, Uniprot Q72547 and Q76353
DOI: 10.7270/q2zw1qc8
title: BindingDB Entry 50009383: Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism.

description: Small molecule binding data for protein CREB-binding protein/Histone acetyltransferase p300, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase KAT6A, Histone acetyltransferase KAT6B, Histone acetyltransferase KAT7, and Histone acetyltransferase p300, Uniprot O95251, Q09472, Q8WYB5, Q92793, Q92794, Q92831, and Q92993
DOI: 10.7270/q2zw1qdq
title: BindingDB Entry 50010001: Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds.

description: Small molecule binding data for protein Neuronal acetylcholine receptor subunit alpha-3/beta-4, Neuronal acetylcholine receptor subunit alpha-4/beta-2, and Neuronal acetylcholine receptor subunit alpha-7, Uniprot P09483, P12390, P17787, P30926, P32297, P36544, P43681, and Q05941
DOI: 10.7270/q2zw1qf5
title: BindingDB Entry 50010558: Aurone: A biologically attractive scaffold as anticancer agent.

description: Small molecule binding data for protein Broad substrate specificity ATP-binding cassette transporter ABCG2, Cyclin-dependent kinase 2, DNA topoisomerase I, and Tyrosinase, Uniprot F1MN93, P14679, P24941, and Q9UNQ0
DOI: 10.7270/q2zw1qgm
title: BindingDB Entry 50010917: Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.

description: Small molecule binding data for protein Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Uniprot Q13627
DOI: 10.7270/q2zw1qh2
title: BindingDB Entry 50011192: Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.

description: Small molecule binding data for protein Fructose-1,6-bisphosphatase 1, Uniprot P09467
DOI: 10.7270/q2zw1qjh
title: BindingDB Entry 50011542: Cannabitwinol, a Dimeric Phytocannabinoid from Hemp,

description: Small molecule binding data for protein Heat sensitive channel TRPV3, Transient receptor potential cation channel subfamily A member 1, Transient receptor potential cation channel subfamily M member 8, Transient receptor potential cation channel subfamily V member 1, Transient receptor potential cation channel subfamily V member 2, and Transient receptor potential cation channel subfamily V member 4, Uniprot Q4QYD9, Q6RI86, Q8NER1, Q8R455, Q9ERZ8, and Q9WUD2
DOI: 10.7270/q2zw1qkz
title: BindingDB Entry 50012159: Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.

description: Small molecule binding data for protein Delta-type opioid receptor, Delta-type/Mu-type opioid receptor, and Mu-type opioid receptor, Uniprot P32300, P35372, P41143, and P42866
DOI: 10.7270/q2zw1qmd
title: BindingDB Entry 50012777: Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB.

description: Small molecule binding data for protein Cathepsin B, Uniprot P07858
DOI: 10.7270/q2zw1qnv
title: BindingDB Entry 50013436: Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis.

description: Small molecule binding data for protein NACHT, LRR and PYD domains-containing protein 3, Uniprot Q8R4B8 and Q96P20
DOI: 10.7270/q2zw1qp9
title: BindingDB Entry 50013783: Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities.

description: Small molecule binding data for protein NACHT, LRR and PYD domains-containing protein 3, Uniprot Q8R4B8
DOI: 10.7270/q2zw1qqr
title: BindingDB Entry 50014078: Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.

description: Small molecule binding data for protein Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 2, and Carbonic anhydrase 7, Uniprot O43570, P00915, P00918, and P43166
DOI: 10.7270/q2zw1qr6
title: BindingDB Entry 50014435: Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

description: Small molecule binding data for protein Immunoglobulin lambda variable 6-57, Uniprot P01721
DOI: 10.7270/q2zw1qsn
title: BindingDB Entry 50014732: Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in Cancer.

description: Small molecule binding data for protein GTPase KRas, Uniprot P01116
DOI: 10.6073/pasta/4e5864da4f6b28acb218b0c05d7bd1f7
title: SRP01 Sequential prairie restoration experiment at Konza Prairie

description: Annual aboveground net primary productivity (ANPP) from the Sequential Prairie Restoration Experiment at the Konza Prairie Long-Term Ecological Research site in Manhattan, KS USA. The data (SRP011) include ANPP from the first three years of restoration in each of three restoration sequences initiated in different years. Data correspond to subplot and whole-plot analyses. The Sequential Prairie Restoration Experiment is a block design with 4 subplots (labeled A - D) within 4 main plots (numbered 1 - 4) sequentially replicated in three blocks (Sequences 1, 2 and 3), with the restoration in each block initiated in a different year (Sequence 1 initiated in 2010, Sequence 2 initiated in 2012, and Sequence 3 initiated in 2014). 'NO-COLL' indicates that variable was not measured, A period in the dataset indicates missing data. Plant species composition data include plant composition from the first two sequences (Sequence I restored in 2010 and Sequence II restored in 2012) in all years from 2010 to 2020 (SRP012); and from the first four sequences (I to IV restored every other year from 2010 to 2016) for the first five growing seasons in each sequence (SRP013).
DOI: 10.6073/pasta/be8cf6c12a7b83985588a454421a0795
title: The effect of salt dosing for chytrid mitigation on tadpoles of a threatened frog, Litoria aurea

description: The novel fungal pathogen Batrachochytrium dendrobatidis (chytrid) is one of the greatest threats to amphibians worldwide. Small increases in water salinity (up to ca. 4 ppt) have been shown to limit chytrid transmission between frogs, potentially providing a way to create environmental refugia to reduce its impact at a landscape scale. However, the effect of increasing water salinity on tadpoles, a life stage confined to water, is highly variable. Increased water salinity can lead to reduced size and altered growth patterns in some species, with flow-on effects to vital rates such as survival and reproduction. It is thus important to assess potential trade-offs caused by increasing salinity as a tool to mitigate chytrid in susceptible frogs. We conducted laboratory experiments to examine the effects of salinity on the survival and development of tadpoles of a threatened frog (Litoria aurea), previously demonstrated as a suitable candidate for trialling landscape manipulations to mitigate chytrid. We exposed tadpoles to salinity ranging from 1-6 ppt and measured survival, time to metamorphosis, body mass and locomotor performance of post-metamorphic frogs as a measure of fitness. Survival and time to metamorphosis did not differ between salinity treatments or controls reared in rainwater. Body mass was positively associated with increasing salinity in the first 14 days. Juvenile frogs from three salinity treatments also showed the same or better locomotor performance compared to rainwater controls, confirming that environmental salinity may influence life history traits in the larval stage, potentially as a hormetic response. Our research suggests that salt concentrations in the range previously shown to improve survival of frogs in the presence of chytrid are unlikely to impact larval development of our candidate threatened species. Our study lends support to the idea of manipulating salinity to create environmental refugia from chytrid for at least some salt-tolerant species.
DOI: 10.6084/m9.figshare.22178669
title: LAPOP Combined Data Set

description: Data set combining 2006, 2008, 2010, 2012, 2014 Domincian Republic datasets from LAPOP AmericasBarometer Survey. Parent datasets publically available at https://www.vanderbilt.edu/lapop/core-surveys.php
DOI: 10.7288/v4/magic/19549
title: MagIC as a FAIR Repository for America's Directional Archaeomagnetic Legacy Data (Dataset)
DOI: 10.5517/ccdc.csd.cc2895sk
title: CCDC 2094198: Experimental Crystal Structure Determination

description: Related Article: Ming-Xing Zhang, Xiaofei Yang, Fen Tan, Hongquan Zhang, Guoping Zeng, Zhiqiang Xu, Sheng Hua Liu|2023|Spectrochim.Acta,Part A|292|122427|doi:10.1016/j.saa.2023.122427
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc28zk72
title: CCDC 2114734: Experimental Crystal Structure Determination

description: Related Article: Ming-Xing Zhang, Xiaofei Yang, Fen Tan, Hongquan Zhang, Guoping Zeng, Zhiqiang Xu, Sheng Hua Liu|2023|Spectrochim.Acta,Part A|292|122427|doi:10.1016/j.saa.2023.122427
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2blp0n
title: CCDC 2162901: Experimental Crystal Structure Determination

description: Related Article: Jiawei Lin|2022|CSD Communication|||
description: Related Article: Niu Sun, Jiawei Lin, Shihui He, Jindong Cao, Zhongnan Guo, Jing Zhao, Quanlin Liu, Wenxia Yuan|2023|Inorg.Chem.|62|3018|doi:10.1021/acs.inorgchem.2c03653
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2btm5z
title: CCDC 2169571: Experimental Crystal Structure Determination

description: Related Article: Xiao-Nan Li, Hang Xu, Li Huang, Yuan Shen, Ming-Jie Li, Hong Zhang|2023|Dyes Pigm.|213|111151|doi:10.1016/j.dyepig.2023.111151
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cjfx8
title: CCDC 2190550: Experimental Crystal Structure Determination

description: Related Article: Błażej Galiński, Jarosław Chojnacki, Ewa Wagner-Wysiecka|2023|Spectrochim.Acta,Part A|293|122472|doi:10.1016/j.saa.2023.122472
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cqcbt
title: CCDC 2196236: Experimental Crystal Structure Determination

description: Related Article: Kunwoo Lee, Nara Kim, Kyung-Bin Cho, Yunho Lee|2023|Inorg.Chem.|62|3007|doi:10.1021/acs.inorgchem.2c03557
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cqccv
title: CCDC 2196237: Experimental Crystal Structure Determination

description: Related Article: Kunwoo Lee, Nara Kim, Kyung-Bin Cho, Yunho Lee|2023|Inorg.Chem.|62|3007|doi:10.1021/acs.inorgchem.2c03557
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2cqcdw
title: CCDC 2196238: Experimental Crystal Structure Determination

description: Related Article: Kunwoo Lee, Nara Kim, Kyung-Bin Cho, Yunho Lee|2023|Inorg.Chem.|62|3007|doi:10.1021/acs.inorgchem.2c03557
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.7295/w9hm56m6
title: Stem cells in kidney of zebrafish
DOI: 10.7295/w9nc5zc0
title: Evolution of multicellular longitudinally dividing oral cavity symbionts (Neisseriaceae)

description: In spite of the staggering number of bacteria that live associated with animals, the growth mode of only a few symbionts has been studied so far. Here, we focused on multicellular longitudinally dividing (MuLDi) Neisseriaceae occurring in the oral cavity of mammals and belonging to the genera Alysiella, Simonsiella and Conchiformibius. Firstly, by applying comparative genomics coupled with ultrastructural analysis, we inferred that longitudinal division evolved from a rod-shaped ancestor of the Neisseriaceae family. Secondly, transmission electron microscopy on cells and sacculi showed that, within each A. filiformis, S. muelleri or C. steedae filament, neighbouring cells are attached by their lateral cell walls. Thirdly, by applying a palette of peptidoglycan metabolic precursors to track their growth, we showed that A. filiformis septates in a distal-to-proximal fashion. In S. muelleri and C. steedae, instead, septation proceeds synchronously from the host-attached poles to midcell. Strikingly, based on confocal-based 3D reconstructions, PG did not appear to be inserted concentrically from the cell periphery to its centre, but as a medial sheet guillotining each cell. Finally, comparative genomics revealed MuLDi-specific differences that set them apart from rod-shaped members of the Neisseriaceae. These MuLDi-specific genetic differences comprise the acquisition of the amidase-encoding gene amiC2, the loss of dgt, gloB, mraZ (an activator of the dcw cluster), rapZ, and amino acids changes in 7 proteins, including the actin homolog MreB and FtsA. Strikingly, introduction of amiC2 and allelic substitution of mreB in the rod-shaped Neisseria elongata resulted in cells with longer septa. In conclusion, we identified genetic events that may have allowed rod-shaped Neisseriaceae to evolve multicellularity and longitudinal division. The morphological plasticity of Neisseriaceae together with their genetic tractability, make them archetypal models for understanding the evolution of bacterial shape, as well as that of animal-bacterium symbioses.