cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10296401
title: Zingiber officinale formulation reduces hepatic injury and weight gain in rats fed an unhealthy diet

description: Abstract: This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. The cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.
DOI: 10.6084/m9.figshare.10296407.v1
title: TRANSCRANIAL DIRECT-CURRENT STIMULATION IN COMBINATION WITH EXERCISE: A SYSTEMATIC REVIEW

description: ABSTRACT Introduction Transcranial direct-current stimulation (tDCS) is a noninvasive technique that allows the modulation of cortical excitability and can produce changes in neuronal plasticity. The application of tDCS has recently been associated with physical activity. Objectives To verify the effect of Transcranial Direct-Current Stimulation (tDCS) in combination with physical exercise, characterizing methodological aspects of the technique. Methods In the database search, studies with animals, other neuromodulation techniques and opinion and review articles were excluded. Publications up to 2016 were selected and the methodological quality of the articles was verified through the PEDro scale. Results The majority of studies (86%) used tDCS on the motor cortex area, with anodal current and the allocation of monocephalic electrodes (46.5%). The prevalent current intensity was 2mA (72%), with duration of 20min (55.8%). The profile of the research participants was predominantly of subjects aged up to 60 years (72.1%). The outcomes were favorable for the use of anodal tDCS in combination with physical exercise. Conclusion Transcranial Direct-Current Stimulation is a promising technique when used in combination with aerobic and anaerobic exercises; however, it is necessary to investigate concurrent exercise. Level of Evidence II; Therapeutic Studies Investigating the Results of Treatment (systematic review of Level II studies or Level I studies with inconsistent results).
DOI: 10.6084/m9.figshare.10296392
title: Surgical treatment strategy in Warthin tumor of the parotid gland

description: Abstract Introduction: Warthin tumors are the second most common benign tumors of the parotid gland. We examined the clinical features of Warthin tumors in our hospital, and analyzed the consistency within the literatures. Objective: The aim of this study is to analyze the clinical features of Warthin tumors in our 10-year experience of 118 Warthin tumors undergoing surgery at a single institute. Methods: From December 2006 to December 2016, 110 patients who underwent surgical treatment for Warthin tumors were identified based on their medical records. Results: A total of 118 parotid gland operations were performed in 110 patients. Almost 90% of Warthin tumors were found in males, and average patient age was 66.1 ± 6.1 years. The prevalence of smoking history was 89.1% (98/110). Eight patients (7.3%) had bilateral Warthin tumors. Seventy-seven lesions (65.3%) were located in the parotid tail portion, followed by 34 lesions in the superficial lobe (28.8%) and 7 lesions in the deep lobe (5.9%). Conclusion: We determined the appropriate extent of surgery depending on the fine needle aspiration cytology and tumor location by computed tomography scans. Partial facial dysfunction after the operation was detected in 12 cases, and facial nerve function recovered within 3 months. Only one patient experienced a recurrence, and was disease free after the re-operation. We suggest that our treatment algorithm, depending on the location of tumors and the result of fine needle aspiration cytology, can be useful to determine the appropriate extent of surgery for Warthin tumors.
DOI: 10.6084/m9.figshare.10296398.v1
title: CHRONIC RESPONSES OF PHYSICAL AND IMAGERY TRAINING ON PARKINSON’S DISEASE

description: ABSTRACT Introduction Physical and motor imagery training is known to induce positive results in the quality of life of patients with neurodegenerative diseases. However, it is not known which effects are achievable when both types of training are combined. Objective This study aimed to investigate the effects of a combination of physical and imagery training on neurotrophin levels, the perception of body dimensions and activities of daily living (ADL) in individuals with Parkinson’s disease (PD). Methods Over an 8-week period, thirteen subjects underwent one hour of aerobic training in combination with twice-weekly imagery training (MIT). The following parameters were measured: brain-derived neurotrophic factor (BDNF) serum levels, level of dependence for activities of daily living (ADLs – Basic [ABDL] and Instrumental [AIDL]), perception of body dimensions and hand laterality test. Results Physical training combined with MIT increased serum BDNF levels in a non-statistically significant manner by 128.08% (88.81 ± 111.83 pg/ml versus 202.56 ± 183.43 pg/ml, p= 0.068). Delta BDNF showed a mean variation of 218.05 ± 547.55% (ES = 1.04). Perception of body dimensions and hand recognition reaction time both improved, but not in a non-statistically significant manner. ADLs (9.52% in ABDLs and 17.76% in AIDLs) improved in a statistically significant manner. Conclusion Despite the small number of subjects, study limitations, and the fact that most results were non-statistically significant, the results obtained here indicate clinical improvement associated with the neurotrophic action of BDNF on the perception of body dimensions and the functional capacity of Parkinson’s disease subjects. Level of evidence II, Therapeutic studies–Investigation of treatment results.
DOI: 10.6084/m9.figshare.10296389
title: Attitudes and Personal Attributes Regarding Patient Receptivity towards the Participation of Medical Students in Gynecological Consultations: A Cross-Sectional Study

description: Abstract Objective To evaluate the association between the acceptance on the part of the patients and their reasons to consent to or refuse medical student attendance during gynecological outpatient care, considering the participants’ demographic characteristics, consultation experience, and gender bias or lack thereof. Methods Face-to-face interviews with patients waiting for gynecological consultations that had been scheduled in advance at Hospital Universitário de Brasília. Contingency analyses were used to determine the levels of association among the patient variables. The accepted significance level was values of p&lt;0.05. Results We interviewed 469 patients. The comfort level with the presence of a student was strongly related to the number of students present during the consultation (Cramér V=0.671). The inclination to grant consent (a series of reasons to consent to or refuse student attendance) was significantly related (p&lt;0.001) to the overall receptivity to student participation (ρ=0.482), the positive appraisal of student-doctor demeanor in previous consultations (ρ=0.253, N=408), and to greater levels of schooling (ρ=0.158). The patients’ receptivity was significantly related (p&lt;0.001) to the lack of bias regarding the gender of the physician (CramérV=0.388), previous experience with students (Cramér V=0.235) and awareness of the fact that they would be present (Cramér V=0.217), older age (ρ=0.136, p=0.003), and multiparity (ρ=0.102, p=0.027). Conclusion Greater receptivity to student participation related significantly to five conditions in decreasing order of strength of association: lack of bias regarding the gender of the Ob-Gyn, previous experience with student involvement, awareness of the presence of students, older age, and multiparity. We also found that a more positive inclination to consent to student attendance correlated positively with a greater receptivity to student participation and to a suitable student-doctor demeanor.
DOI: 10.6084/m9.figshare.10296392.v1
title: Surgical treatment strategy in Warthin tumor of the parotid gland

description: Abstract Introduction: Warthin tumors are the second most common benign tumors of the parotid gland. We examined the clinical features of Warthin tumors in our hospital, and analyzed the consistency within the literatures. Objective: The aim of this study is to analyze the clinical features of Warthin tumors in our 10-year experience of 118 Warthin tumors undergoing surgery at a single institute. Methods: From December 2006 to December 2016, 110 patients who underwent surgical treatment for Warthin tumors were identified based on their medical records. Results: A total of 118 parotid gland operations were performed in 110 patients. Almost 90% of Warthin tumors were found in males, and average patient age was 66.1 ± 6.1 years. The prevalence of smoking history was 89.1% (98/110). Eight patients (7.3%) had bilateral Warthin tumors. Seventy-seven lesions (65.3%) were located in the parotid tail portion, followed by 34 lesions in the superficial lobe (28.8%) and 7 lesions in the deep lobe (5.9%). Conclusion: We determined the appropriate extent of surgery depending on the fine needle aspiration cytology and tumor location by computed tomography scans. Partial facial dysfunction after the operation was detected in 12 cases, and facial nerve function recovered within 3 months. Only one patient experienced a recurrence, and was disease free after the re-operation. We suggest that our treatment algorithm, depending on the location of tumors and the result of fine needle aspiration cytology, can be useful to determine the appropriate extent of surgery for Warthin tumors.
DOI: 10.6084/m9.figshare.10296383
title: Microsatellites for detecting inconsistencies in Capsicum cultivars registration in Brazilian database: more than meets the eye

description: ABSTRACT In Brazil, cultivars are registered by National Register of Cultivars (RNC), which besides enabling commercialization of cultivar propagative material, also guarantees the producers genetic purity and identity of propagules. However, it is possible that the information about registration and commercialization of some cultivars is inaccurate. This study aims to analyze the use of microsatellite markers to detect inconsistencies in data of Capsicum spp. cultivars obtained from the official database (CultivarWeb). Seven cultivars were evaluated, three of them were through genetic identity analysis (Amarela Comprida, De Cayenne and Cayenne Long Slin) and the others were used as standard for the species C. annuum, C. frutescens and C. chinense. Thirty-three microsatellite loci were polymorphic and presented 76 alleles (an average of 2.3 alleles/locus). Fixation Index (F) showed high homozygosis and estimators of genetic diversity (Ho and I) presented low genetic diversity among cultivars. The molecular analysis, represented in a dendrogram and in Principal Coordinate Analysis Chart (PCOA), showed that the investigated cultivars belong to C. annuum, contrary to what is registered in CultivarWeb, which indicates that such cultivars belong to the species C. frutescens. Thus, the authors recommend that the data in the CultivarWeb should be checked and enhanced.
DOI: 10.6084/m9.figshare.10296389.v1
title: Attitudes and Personal Attributes Regarding Patient Receptivity towards the Participation of Medical Students in Gynecological Consultations: A Cross-Sectional Study

description: Abstract Objective To evaluate the association between the acceptance on the part of the patients and their reasons to consent to or refuse medical student attendance during gynecological outpatient care, considering the participants’ demographic characteristics, consultation experience, and gender bias or lack thereof. Methods Face-to-face interviews with patients waiting for gynecological consultations that had been scheduled in advance at Hospital Universitário de Brasília. Contingency analyses were used to determine the levels of association among the patient variables. The accepted significance level was values of p&lt;0.05. Results We interviewed 469 patients. The comfort level with the presence of a student was strongly related to the number of students present during the consultation (Cramér V=0.671). The inclination to grant consent (a series of reasons to consent to or refuse student attendance) was significantly related (p&lt;0.001) to the overall receptivity to student participation (ρ=0.482), the positive appraisal of student-doctor demeanor in previous consultations (ρ=0.253, N=408), and to greater levels of schooling (ρ=0.158). The patients’ receptivity was significantly related (p&lt;0.001) to the lack of bias regarding the gender of the physician (CramérV=0.388), previous experience with students (Cramér V=0.235) and awareness of the fact that they would be present (Cramér V=0.217), older age (ρ=0.136, p=0.003), and multiparity (ρ=0.102, p=0.027). Conclusion Greater receptivity to student participation related significantly to five conditions in decreasing order of strength of association: lack of bias regarding the gender of the Ob-Gyn, previous experience with student involvement, awareness of the presence of students, older age, and multiparity. We also found that a more positive inclination to consent to student attendance correlated positively with a greater receptivity to student participation and to a suitable student-doctor demeanor.
DOI: 10.6084/m9.figshare.10296401.v1
title: Zingiber officinale formulation reduces hepatic injury and weight gain in rats fed an unhealthy diet

description: Abstract: This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. The cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.
DOI: 10.6084/m9.figshare.10296374
title: DESAFIOS À CIRCULAÇÃO NA FRONTEIRA ENTRE BRASIL E GUIANA FRANCESA (FRANÇA)

description: Resumo Brasil e França compartilham uma larga fronteira na Amazônia. Nosso intuito neste texto é avaliar quais foram as ações empreendidas pelas quais o sistema de circulação da bacia do Rio Oiapoque foi alvo de re-desenhos desde o estabelecimento do limite internacional em 1900. A partir da utilização de bibliografia específica sobre o tema, bem como da realização de trabalho de campo em diferentes momentos, concluímos que os re-desenhos impuseram ao menos três grandes mudanças até hoje: i) a circulação líquida (fluvial), anteriormente hegemônica, é hoje posta em concorrência pela circulação dura (terrestre); ii) vê-se a substituição de acordos (ou normas informais) locais pela prevalência de regras internacionais; e iii) nota-se uma contradição nas relações bilaterais: o discurso oficial de integração valoriza o aumento da interface entre as duas margens do Rio enquanto a prática aponta para uma diminuição e um endurecimento das regras de circulação.
DOI: 10.6084/m9.figshare.10296380
title: Morphometric characteristics of the Mangalarga Marchador horse breed determined by nonlinear models

description: Abstract: The objective of this work was to evaluate the development of the morphometric characteristics of Mangalarga Marchador horses through nonlinear models. The transversal method was used to collect data on height at the withers (HW), body length (BL), and thoracic (TP) and cannon (CP) perimeters from 200 horses (75 males and 125 non-pregnant females), aged between 6 and 153 months. The parameters of the Brody, Gompertz, logistic, and von Bertalanffy nonlinear models were estimated using the R software. Models were compared and selected using the coefficient of determination, the residual standard deviation, and the corrected Akaike information criterion. For adult females, HW, BL, TP, and CP ranged between 146.45-148.34, 148.59-151.64, 179.07-182.88, and 18.25-18.76 cm, respectively. For males, HW, BL, and CP ranged between 148.55-151.80, 150.77-154.88, and 18.95-19.41 cm, respectively. The logistic model best expresses growth in HW for males and females, as well as in BL and CP for males, whereas the Brody model is the best predictor for HW, BL, TP, and CP for females. The increase in the values of the morphometric measurements is more rapid and homogeneous between the ages of 6 and 24 months, stabilizing at 60 months in both sexes.
DOI: 10.6084/m9.figshare.10296377
title: Human Chorionic Gonadotropin monotherapy for the treatment of hypogonadal symptoms in men with total testosterone &gt; 300 ng/dL

description: ABSTRACT Purpose The 2018 American Urological Association guidelines on the Evaluation and Management of Testosterone Deficiency recommended that 300 ng/dL be used as the threshold for prescribing testosterone replacement therapy (TRT). However, it is not uncommon for men to present with signs and symptoms of testosterone deficiency, despite having testosterone levels greater than 300 ng/dL. There exists scant literature regarding the use of hCG monotherapy for the treatment of hypogonadism in men not interested in fertility. We sought to evaluate serum testosterone response and duration of therapy of hCG monotherapy for men with symptoms of hypogonadism, but total testosterone levels &gt; 300 ng/dL. Materials and Methods We performed a multi-institutional retrospective case series of men receiving hCG monotherapy for symptomatic hypogonadism. We evaluated patient age, treatment indication, hCG dosage, past medical history, physical exam findings and serum testosterone and gonadotropins before and after therapy. Descriptive analysis was performed and Mann Whitney U Test was utilized for statistical analysis. Results Of the 20 men included in the study, treatment indications included low libido (45%), lack of energy (50%), and erectile dysfunction (45%). Mean testosterone improved by 49.9% from a baseline of 362 ng/dL (SD 158) to 519.8 ng/dL (SD 265.6), (p=0.006). Median duration of therapy was 8 months (SD 5 months). Fifty percent of patients reported symptom improvement. Conclusions Treatment of hypogonadal symptoms with hCG for men who have a baseline testosterone level &gt; 300 ng/dL appears to be safe and efficacious with no adverse events.
DOI: 10.6084/m9.figshare.10296380.v1
title: Morphometric characteristics of the Mangalarga Marchador horse breed determined by nonlinear models

description: Abstract: The objective of this work was to evaluate the development of the morphometric characteristics of Mangalarga Marchador horses through nonlinear models. The transversal method was used to collect data on height at the withers (HW), body length (BL), and thoracic (TP) and cannon (CP) perimeters from 200 horses (75 males and 125 non-pregnant females), aged between 6 and 153 months. The parameters of the Brody, Gompertz, logistic, and von Bertalanffy nonlinear models were estimated using the R software. Models were compared and selected using the coefficient of determination, the residual standard deviation, and the corrected Akaike information criterion. For adult females, HW, BL, TP, and CP ranged between 146.45-148.34, 148.59-151.64, 179.07-182.88, and 18.25-18.76 cm, respectively. For males, HW, BL, and CP ranged between 148.55-151.80, 150.77-154.88, and 18.95-19.41 cm, respectively. The logistic model best expresses growth in HW for males and females, as well as in BL and CP for males, whereas the Brody model is the best predictor for HW, BL, TP, and CP for females. The increase in the values of the morphometric measurements is more rapid and homogeneous between the ages of 6 and 24 months, stabilizing at 60 months in both sexes.
DOI: 10.6084/m9.figshare.10296383.v1
title: Microsatellites for detecting inconsistencies in Capsicum cultivars registration in Brazilian database: more than meets the eye

description: ABSTRACT In Brazil, cultivars are registered by National Register of Cultivars (RNC), which besides enabling commercialization of cultivar propagative material, also guarantees the producers genetic purity and identity of propagules. However, it is possible that the information about registration and commercialization of some cultivars is inaccurate. This study aims to analyze the use of microsatellite markers to detect inconsistencies in data of Capsicum spp. cultivars obtained from the official database (CultivarWeb). Seven cultivars were evaluated, three of them were through genetic identity analysis (Amarela Comprida, De Cayenne and Cayenne Long Slin) and the others were used as standard for the species C. annuum, C. frutescens and C. chinense. Thirty-three microsatellite loci were polymorphic and presented 76 alleles (an average of 2.3 alleles/locus). Fixation Index (F) showed high homozygosis and estimators of genetic diversity (Ho and I) presented low genetic diversity among cultivars. The molecular analysis, represented in a dendrogram and in Principal Coordinate Analysis Chart (PCOA), showed that the investigated cultivars belong to C. annuum, contrary to what is registered in CultivarWeb, which indicates that such cultivars belong to the species C. frutescens. Thus, the authors recommend that the data in the CultivarWeb should be checked and enhanced.
DOI: 10.6084/m9.figshare.10296368
title: Floors number influence on the instability parameter of reinforced concrete frame-braced buildings

description: Abstract This work aims to investigate the floors number influence on the instability parameter limit α1 of reinforced concrete frame-braced buildings; it succeeds another work in this field of knowledge, in which the same question was investigated for wall- and core-braced buildings. Initially, it is showed how the ABNT NBR 6118:2014 (Brazilian code for concrete structures design) defines when a second order analysis is needed. Topics concerning to physical nonlinearity consideration and to the lateral deflection components of frames are also presented. It follows an analytical study that led to the derivation of a method for determining the limit α1 as a function of the floors number and the relation between bending and shear stiffness. Finally, some examples are presented and their results are used for checking the method accuracy.