cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2015.310
title: Formulation of extemporaneous amphotericin b topical preparations containing high amount of dimethyl sulfoxide for the treatment of onychomycosis

description: The main purpose of this research was to formulate the stable extemporaneous Amphotericin B topical preparation in a treatment onychomycosis and to determine beyond-use date of the product. To date, there is no marketed topical Amphotericin B product available in Thailand and no data available on stability of these preparations. The formulations in this study were prepared from a commercial Amphotericin B for injection. Three Amphotericin B topical preparations; i.e. o/w emulsion, hydrophilic ointment and gel, were developed. The preparations were formulated with high amount of dimethyl sulfoxide (DMSO) as a nail permeation enhancer and use Tris-hydrochloride buffer for controlling pH value of the preparation at pH 7. The physical stabilities of these formulations were tested by heating-cooling method (4°C for 48 hours – 45°C for 48 hours) and also monitored for appearance changes. The amphotericin B gel lost its viscosity and showed visible non-uniformity due to precipitation of Amphotericin B after stability testing. The preparations were storage at 30±2oC up to 60 days. During that time, Amphotericin B was quantified by high-performance liquid chromatography (HPLC). The extemporaneous Amphotericin B cream and ointment containing 30% concentrations of DMSO were stable for 60 days. Moreover, the In vitro permeation to clipping nail plates from healthy human volunteer showed that Amphotericin B in cream and ointment could permeate into nail plate when compared with the self-base formulation. The ointment formulation was better than cream (p &lt; 0.05). The stable cream and ointment containing 3% Amphotericin B were obtained for further clinical study to evaluate the therapeutic and adverse effects, including the patient’s satisfaction.
DOI: 10.13145/bacdive137690.20191129.4.1
title: Campylobacter sputorum

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137691.20191129.4.1
title: Gemella haemolysans

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.311
title: Development and characterization of bisdemethoxycurcumin-loaded solid lipid nanoparticles

description: The aim of study was to develop solid lipid nanoparticles containing bisdemethoxycurcumin using rice bran wax compared to glyceryl behenate and cetyl palmitate for pharmaceutical application. Rice bran wax is a by-product from rice bran oil refinery. It contains potent antioxidant of gamma oryzanol utilized in pharmaceuticals. Solid lipid nanoparticles (SLN) were prepared by high pressure homogenization technique using different type and amount concentration of lipid, and stabilized by tween 80. Type and concentration of lipids influenced the physicochemical properties of the SLN. RB-SLN had larger particle size than GB-SLN and CP-SLN. The higher the concentration of lipid, the larger was the particle size. Also, the higher the amount of tween 80 in SLN, the better was physical stability. Bisdemethoxycurcumin-loaded SLN (BDMC-SLN) appeared as a homogeneous dispersion with spherical shape in nanosize range. BDMC-SLN with RB had the largest particle size and the highest entrapment efficiency. In vitro release study of the BDMC-SLN exhibited a sustained release pattern. Increasing the lipid concentration resulted in sustaining the BDMC released. BDMC-loaded solid lipid nanoparticles using rice bran wax was successfully prepared. This rice bran lipid carrier provided better physical properties, entrapment efficiency and stability.
DOI: 10.13145/bacdive137692.20191129.4.1
title: Gemella bergeri

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.312
title: Mechanism of antiplatelet aggregation of angelica dahurica extract in human platelets

description: Angelica dahurica extract (ADE) has been shown to exhibit antiplatelet aggregation properties, which promise to be used as a therapeutic agent for circulatory disorder. The aim of the present study was to investigate the mechanism of ADE in antiplatelet aggregation in human platelets. The effect of ADE on human platelet aggregation induced by adenosine diphosphate (ADP, 40 µM) and collagen (20 µg/ml) were explored in vitro, and the potential mechanism such activity were investigated using western blot analysis. The result showed that ADE at the concentration of 0.1, 0.25, 0.5 and 1 mg/ml significantly inhibited ADP-induced platelet aggregation by 38.2±13.7% (p&lt;0.05), 50.2±11.6% (p=0.01), 73.4±8.5% (p&lt;0.001) and 79.8±7.4% (p&lt;0.001), respectively when compare to vehicle control. ADE at the concentration of 0.5 and 1 mg/ml significantly activated the phosphorylation of vasodilator-stimulated phosphoprotein (VASP) at Ser157 (6.7±2.3 and 8.3±2.2; p&lt;0.05), more than those at Ser239 (3.0±1.4; p=0.054 and 5.1±1.5; p=0.054), respectively, suggesting that VASP phosphorylation could mediated mainly through cAMP/PKA pathway. ADE at concentration of 0.1, 0.25, 0.5 and 1 mg/ml significantly inhibited collagen-induced platelet aggregation by 52.8±1%, 60.6±8.9%, 84.3±2% and 85.8± 2.3% (p&lt;0.001), respectively when compare to vehicle control. ADE did not decrease phosphorylation of Akt at Thr308. In conclusion, the mechanism of antiplatelet aggregation of ADE may include the increase of VASP phosphorylation and mediated through cAMP/PKA pathway.
DOI: 10.13145/bacdive137693.20191129.4.1
title: Facklamia ignava

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.313
title: Development of calcium and cholecalciferol fortified ice cream

description: Calcium and vitamin D play important roles in bone homeostasis. Several studies reported inadequate intakes of these two nutrients in many population groups. Food fortification is one way to solve the problem. The objective of this study was to determine the effects of fortification of ice cream with calcium and vitamin D3. Five ice cream formulations contained different amounts of fat including regular fat (RF), reduced fat (RDF), light (L), low fat (LF) and fat free (FF) (10%, 7.5%, 5%, 2.5% and &lt; 0.625% fat content, respectively). Inulin was used as a fat replacement in LF and FF formulas. Two hundreds mg of elemental calcium and 200 IU of vitamin D3 per serving were fortified in each formula. Ice creams were stored at -20 ˚C. Physical and microbiological properties were evaluated on day 0, 7, 14, and 28. Overrun of L and FF were higher than RF, RDF and FF (P &lt; 0.05). Hardness tended to increase as the lower of fat content of an ice cream and as the longer the products stored. Melting rate inclined with further reduction of fat on day 0, but no significant difference was found among the formulations on day 14 and 28. The ice creams formulated with inulin had lower viscosity (P &lt; 0.05) compared to the non-containing inulin formulas at all the time points. Aerobic plate counts were less than 100 CFU/mL, and no E. coli and coliform found at 1:100 dilutions throughout the study. Calcium was preserved; however, alternative techniques of vitamin D fortification may be needed to improve the stability.
DOI: 10.13145/bacdive137694.20191129.4.1
title: Brachyspira alvinipulli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137695.20191129.4.1
title: Campylobacter fetus

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.314
title: Improving coal sales profit by alternative blending processes

description: The purpose of this research is to improve coal sales profit by alternative coal blending process. The main objective of this research is to improve operational profit of the company by developing alternative coal blending process across 2 coal mines from various raw coal qualities to get coal products to be matched with customers’ requirement. The study consists of two main parts that are the planning part and the calculation of alternative blending part. The planning part begins with gathering all information, classifying coal quality, identifying limitation, and creating blending model. The second stage is calculation of alternative blending part starts from assessing impacts of revenue and cost from changing operation process, preparing new blending calculation model for new blending plan, and then study of sensitivity of main factors, coal price and oil price. The result of best blending plan show the profit from new blending is 42.3 million US$ which higher than profit of original plan which is 33.7 million US$. The company can get more profit about 25.6 percent compared with profit from original plan. Moreover, the result sensitivity study of coal price and oil price has confirmed that profit from alternative blending process is higher than original plan even though these two factors are changed up to 50 percent.
DOI: 10.13145/bacdive137696.20191129.4.1
title: Elizabethkingia meningoseptica

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.315
title: MODELING OF NANO-BEAMS UNDER GENERAL LOADING CONDITIONS

description: This thesis presents the analysis of bending, buckling, and post-buckling responses of a nano-beam under different end conditions. Both surface and non-local effects via Gurtin-Murdoch surface elasticity and Eringen non-local elasticity models are integrated into the classical Euler-Bernoulli beam theory to obtain a mathematical model capable of simulating the nano-scale influence and size-dependency of observed physical phenomena. The key governing equations for a deflected shape are formulated first within the context of large displacements and rotations using a classical elliptic integral technique and their linearized version is then established to form the eigen-value problem governing the buckling load. A conventional analytical procedure for eigen-hunt is employed to determine the exact buckling load whereas Newton-Raphson iterative scheme is adopted to solve a final system of nonlinear algebraic equations to obtain the deflected shape and other related quantities. Obtained results demonstrate that both the surface and non-local effects significantly influence the buckling load and bending and post-buckling responses of nano-beams. In particular, presence of those effects tends to reduce the overall stiffness of the beam and, as a result, decrease the buckling load for all cases considered. In addition, the predicted solutions exhibit strongly size-dependent and are significantly influenced by both the surface and non-local parameters (e.g., surface modulus of elasticity and residual surface tension) when the characteristic length of the beam is comparable to the intrinsic length of the material surface.
DOI: 10.13145/bacdive137697.20191129.4.1
title: Pseudomonas aeruginosa

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137698.20191129.4.1
title: Pelistega europaea

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137699.20191129.4.1
title: Paenibacillus edaphicus

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.317
title: The Experiences of Franchise Business Regulations in the United States, the European Union and South Korea: Lessons for Thailand

description: Franchise is a business system which is increasing and becoming popular in both Thailand and foreign countries. Franchise business occurs through franchise agreement to distribute goods and services between franchisor and franchisee. Franchisee conducts his business by franchisor’s knowledge and trademark then pays franchise fee in return. Generally, franchisor has more bargaining and market power to impose such the unfair contract terms in the franchise agreement. Those terms may take too many advantages from other party and becomes illegal. It has been found from the study that currently Thailand has no specific law regulating franchise business. Thailand regulates franchise business by the Civil and Commercial Code, the Unfair Contract Term Act and the Competition Act. Through this study, the experiences of franchise business regulations in the United States and South Korea are effective in the aspect of the specific law regulating franchise business. Franchisors are required to disclose the substantial information. Moreover, both countries have the commission to look after the fairness in franchise business particularly. As for the competition law in the United States, the European Union and South Korea are effective and franchise businesses are applicable. In order to improve the franchise business regulation in Thailand. While the franchise specific law is in the developing process, making guideline for franchise business in Thailand is recommended. This guideline contains all essential information and in the respect of clarifying the unfair contract term provision. The guideline will play the substantial role by combining franchise specific law and competition law together.
DOI: 10.13145/bacdive137700.20191129.4.1
title: Klebsiella pneumoniae

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137701.20191129.4.1
title: Brachyspira intermedia

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.318
title: Legal measures relating to supervision and roles of hedge fund manager in Thailand

description: The objective of this thesis was to study supervision and roles of hedge fund managers from foreign law in order to ensure appropriate perceptions of their responsibilities and help sustain growth in the Thai financial system. The researcher examined the relevant laws in three foreign nations including the United States (US), United Kingdom (UK), and South Korea to compare the legal development of hedge fund managers. The results found that the supervision of hedge fund managers developed from the beginning. Additionally, a hedge fund manager’s role falls into the same category as a mutual fund manager, which means it involves similar regulatory oversight. Moreover, a hedge fund manager may commit fraud against investors or get involved in situations where conflict of interest may affect the interests of investors. Unfortunately, there are no regulations for hedge fund managers in Thailand. However, both hedge fund managers and mutual fund managers have similarities in the substance of their roles. As such, both should be regulated similarly in term of regulatory oversight. Once the activities of hedge fund managers are regulated, they are obligated to comply with certain rules designed to protect investors as well as the public interest. Hence, it is necessary to adopt and adjust some legal measures concerning securities regulation, fund management licensing and investor qualifications for a hedge fund manager to support the growth of the hedge fund industry in Asia and protect Thai investors.
DOI: 10.13145/bacdive137702.20191129.4.1
title: Corynebacterium ulcerans

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137703.20191129.4.1
title: Escherichia coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.319
title: A Comparative Study of the Determination of Applicable Laws on Contractual Obligations under EU, Chinese and Thai Laws and Regulations

description: The current Thai conflict law on contractual obligations has some defects and it should be amended to keep pace with other jurisdictions such as EU and China. The defects of the current Thai conflict law on contractual obligations include the default of the rule of the most significant connection, the uncertainty of Renvoi, the default of overriding mandatory rules, and the absence of some legal terms adopted by other legislation. The author recommends that the amendment should consider these proposals: Firstly, the rule of the most significant connection should be adopted by the legislation in case the choice of law is absent in the contract. Secondly, it should exclude Renvoi in the field of contract law expressly by which will bring more stability and predictability into the legal outcome. Thirdly, not only the reservation of public policy, but the overriding mandatory rules also are adopted by the amendment which will help the weaker party to the contract or the domestic political, financial, and economic order of Thailand. Finally, the connecting factors of ‘characteristic performance’ and ‘habitual residence’ should be taken into account into the new Thai rule of conflict of law, which will benefit the Thai court to allocate the substantially applicable rules.
DOI: 10.13145/bacdive137704.20191129.4.1
title: Escherichia coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.320
title: Corporate Criminal Liability for its Criminal Conduct

description: This research is concerned with criminal responsibility of legal entities focusing on employers who are legal entities where their employees commit criminal offenses to a third party which is called “vicarious liability”. The criminal responsibility of the legal entity as an employer occurs when he or she shows intention towards the legal entity’s actions or consequences from the intention, resulting benefits to a legal entity. As the legal entity means a non-existent person, any actions are performed through its legal representatives. Thus, in considering whether the legal entity is responsible can determine from vicarious liability. The individual acts as a legal representative or a person whose duties are to perform any actions instead of the legal entity. In Thailand, legal provisions with criminal punishment authority upon legal entity for this case are not enough. As a result, the employers do not realize about safety of lives, bodies, belongings, freedom etc. of others as much as they should. As a consequence, some legal violations from employees lead to benefits for the employers. While, foreign countries have strict measures for the penalty of legal entity employers. The proper approach for the enactment that employers must be responsible for criminal penalty of the employees is derived by comparison between foreign laws and court judgments in order to make the employer who is legal entity focusing on carefulness to operate a business, prevent or control their employees’ behaviors that would not perform any criminal violation or cause any damage to other party.Therefore, the researcher will suggest the appropriate measure for define the specific criminal provisions to the juristic person which separates from the natural person in order to solve many problems according to the juristic act in the civil law system. Hence, the criminal punishment for the juristic person should base on the factor that affects to the juristic person’s cherish things by adjusting criminal punishments of juristic person specifically such as dissolution, operation prohibition or revocation of licenses, detention, cessation, exclusion from public bidding, prohibition on public fundraising, prohibition on the uses of cheque or credit cards, fine, confiscation, victim notification or pay compensation by the juristic person.This punishments should be enforced and legislated to general principle in Penal Code obviously for the corporate criminal liability.
DOI: 10.13145/bacdive137705.20191129.4.1
title: Escherichia coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.14457/cu.the.2015.321
title: CD4 cell counts level and risks of Cutaneous Adverse Drug Reactions in HIV-infected patients receiving standard anti-tuberculosis drugs in Thailand

description: Objectives: Tuberculosis is the major cause of morbidity and mortality in HIV-infected patients. Anti-tuberculosis drugs can cause cutaneous adverse drug reactions (CADRs). This study was conducted to evaluate the difference in CADRs incidence between low and high CD4 cell count and to identify other CADRs risk factors in HIV/TB co-infected patients. Methods: We collected a retrospective cohort of adult HIV/tuberculosis co-infected patients receiving a standard anti-tuberculosis regimens between 1 Jan 2008 – 31 Dec 2015 at Vajira hospital, Thailand. Baseline demographic, clinical characteristics and factors associated with CADRs included CD4 cell count status were collected. Results: Of 307 patients enrolled, CADRs were found in 48 patients during six months period of tuberculosis treatment (Incidence rate = 0.41 events/person-year). Maculopapular rash was the most prevalent CADRs. Low CD4 cell count are not the risk of CADRs. Cox regression analysis revealed a moderate decrease in GFR, history of drug hypersensitivity and concomitant Co-trimoxazole use were all associated with CADRs. Concomitant antiretroviral use was associated with lower risk of CADRs. However, the analysis revealed no different in the time to CADRs between patients with lower and higher CD4 cell count. Conclusions: CADRs are common in HIV/TB co-infected patients. Early recognition and prompt withdrawal of suspected agent could prevent complications and improve tuberculosis care.
DOI: 10.13145/bacdive137706.20191129.4.1
title: Escherichia coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive137707.20191129.4.1
title: Escherichia coli

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.