cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7483/opendata.cms.pajb.pc7g
title: /ZH_HToZZTo4Q_2LFilter_M300_CP5TuneUp_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v3/MINIAODSIM
DOI: 10.7483/opendata.cms.vtl7.6x4t
title: /ZH_HToZZTo4Q_2LFilter_M300_CP5TuneUp_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.cbcf.hily
title: /ZH_HToZZTo4Q_2LFilter_M300_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/3ncbhdd4nw.1
title: Mobility, Kinematic, and Dynamic Analysis of a 4R1H Mechanism. Julia Files

description: This dataset contains Julia files that perform mobility, kinematic, and dynamic analysis of a 1-DOF single-loop 4R1H mechanism, which is similar to the mechanism presented in paper https://doi.org/10.1007/978-3-031-45709-8_39. The corresponding paper describing the mechanism design and applied algorithms is going to be published in the Robotica journal. Please check the list of works at https://orcid.org/0000-0002-3928-5440.

The dataset includes the following files:
1. File "main.jl" is the main file that proceeds with the mobility, kinematic, and dynamic analysis of the mechanism step by step.
2. File "init.jl" is used to define geometrical and inertial parameters of the mechanism links.
3. File "mobility.jl" computes a twist system of the output link.
4. File "kinematics.jl" computes kinematic parameters (positions, velocities, accelerations, etc.) of the links.
5. File "dynamics.jl" computes the motor torque required to realize the desired motion.
6. File "plots.jl" includes functions that visualize the results of the kinematic and dynamic analysis.
DOI: 10.7483/opendata.cms.1ruk.jrvc
title: /ZH_HToZZTo4Q_2LFilter_M300_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/9j7mr579m2.1
title: LINF_360069300

description: Cytidine deaminase; Leishmania infantum (strain JPCM5)
DOI: 10.7483/opendata.cms.farr.ii4g
title: /ZH_HToZZTo4Q_2LFilter_M350_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/mx5w3492xd.1
title: LINF_360073400

description: glucose transporter
Leishmania infantum (strain JPCM5)
DOI: 10.7483/opendata.cms.f6mh.0uj5
title: /ZH_HToZZTo4Q_2LFilter_M350_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.cbmk.b0a4
title: /ZH_HToZZTo4Q_2LFilter_M400_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.0gc2.97my
title: /ZH_HToZZTo4Q_2LFilter_M400_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.c0df.m53o
title: /ZH_HToZZTo4Q_2LFilter_M450_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.fuwy.p5vv
title: /ZH_HToZZTo4Q_2LFilter_M450_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.k8bu.si0e
title: /ZH_HToZZTo4Q_2LFilter_M500_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.u9sz.dsrl
title: /ZH_HToZZTo4Q_2LFilter_M500_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.mk67.brka
title: /ZH_HToZZTo4Q_2LFilter_M550_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v3/MINIAODSIM
DOI: 10.7483/opendata.cms.lkbb.ytva
title: /ZH_HToZZTo4Q_2LFilter_M550_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.yjhn.er3s
title: /ZH_HToZZTo4Q_2LFilter_M600_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v4/MINIAODSIM
DOI: 10.7483/opendata.cms.cry6.esqz
title: /ZH_HToZZTo4Q_2LFilter_M600_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.frii.xcga
title: /ZH_HToZZTo4Q_2LFilter_M700_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v3/MINIAODSIM
DOI: 10.7483/opendata.cms.5bkn.wu7c
title: /ZH_HToZZTo4Q_2LFilter_M700_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.gr1s.g1qg
title: /ZH_HToZZTo4Q_2LFilter_M800_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v4/MINIAODSIM
DOI: 10.7483/opendata.cms.nlqh.79dz
title: /ZH_HToZZTo4Q_2LFilter_M800_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.lbz4.55tq
title: /ZH_HToZZTo4Q_2LFilter_M900_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v4/MINIAODSIM
DOI: 10.7483/opendata.cms.b06e.iaj4
title: /ZH_HToZZTo4Q_2LFilter_M900_TuneCP5_13TeV_powheg2-minlo-HZJ_JHUGenV735_pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.g54b.o5g1
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-0cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/nby5cb7prw.1
title: LINF_360070200

description: FAP206-like protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/k6kv4pm778.1
title: LINF_360079600

description: FCP1 domain-containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.7483/opendata.cms.tvs2.irc0
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-0cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/tdvstvpy25.1
title: LINF_360080200

description: Amino acid transporter | AAT29; Leishmania infantum (strain JPCM5)
DOI: 10.7483/opendata.cms.wiwo.d8hp
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-0cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.cmmk.dsw6
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-0cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/496h7bv7cx.1
title: Bumblebee Thermal Tolerance

description: Maximal critical thermal tolerance (CTmax) of castes and larvae of a bumblebee (Bombus impatiens) and the effect of environmental temperature on the colony metabolic rate and nest temperature. Larval CTmax is significantly lower than the CTmax of adult castes. Whole-colony thermoregulation is energetically costly at high and low temperatures. Colonies experiencing 30°C and below successfully thermoregulate nest temperature. Above 30°C, nest temperature cannot be regulated via colonial thermoregulation.
DOI: 10.17632/tvbt76bnbf.3
title: A Study of "Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection". Chaguza et al

description: Supplementary Dataset for the manuscript "Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection"
DOI: 10.7483/opendata.cms.rj0f.djqw
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-1000cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/kv8p3skfcx.1
title: Raw data of the manuscript entitled "Inflammation and Fibrotic Diseases: Landscape Analysis and Overview of the Literature".

description: The following is the raw data of the manuscript entitled "Inflammation and Fibrotic Diseases: Landscape Analysis and Overview of the Literature".
DOI: 10.17632/kv8p3skfcx.2
title: Raw data of the manuscript entitled "Inflammation and Fibrotic Diseases: Landscape Analysis and Overview of the Literature".

description: The following is the raw data of the manuscript entitled "Inflammation and Fibrotic Diseases: Landscape Analysis and Overview of the Literature".
DOI: 10.17632/kv8p3skfcx.3
title: Raw data of the manuscript entitled "Trends and Insights in Fibrosis Research: a 71-Year Bibliometric Study".

description: The following is the raw data of the manuscript titled "Trends and Insights in Fibrosis Research: a 71-Year Bibliometric Study".
DOI: 10.7483/opendata.cms.1spl.x8vy
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-1000cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/ry5dkty7t7.4
title: TiTuSS Transport Database

description: The excel file provides a longitudinal database which integrates information for the road networks with demographic, administrative and socioeconomic data for the municipalities of mainland Portugal over the 50-year period from 1971 to 2020. Although the database refers to the road network and road-based accessibility, it also includes simple measures of the railway network, namely the number of active railway stations in each municipality and the road-based distance and travel time to the nearest active railway station. The database can be used to study the effects of improved road accessibility on multiple socioeconomic outcomes in Portugal (e.g., population growth/decline, employment growth/decline, regional cohesion, urbanization patterns, etc.) over a considerable long period of 50 years. The database was constructed as part of the project TiTuSS-Transport Infrastructure & Urban Spatial Structure: Economic, Social & Environmental Effects (PTDC/EGE-PTDC/EGE-ECO/28805/2017).
DOI: 10.7483/opendata.cms.tick.3cmd
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-1000cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/5d8ygb5d97.3
title: Karataş_Hicran_Qualitative_interviews_with_dialysis_patients_waiting_for_cadaveric_organ_donation
DOI: 10.7483/opendata.cms.xd2q.ysgs
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-1000cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/rjpjyykxvf.2
title: Forcecasted MSW generation and Economic damage in SSA

description: This data is related to the research paper, "Mitigating greenhouse gas emissions from municipal solid waste in Sub-Saharan Africa via sustainable waste management: An economic benefit assessment." The data corresponds to forecasts of electricity generation and GHG emission reductions in 44 sub-Saharan African countries. This includes the potential for energy generation from organic MSW as well as the economic viability of waste-to-energy projects in Sub-Saharan Africa. This data also includes the environmental costs of improper waste management. Forecasted data on MSW generation and methane emissions from landfill sites are estimated for 100 years (from 2000 to 2100). This data is estimated using data from trusted official documents from the IPCC, IMF, World Bank, and United Nations, and is supplemented as needed with information from literature and country-specific databases. The data showed how important it is for Sub-Saharan Africa to switch to using waste as a source of energy and to use waste in a more sustainable way.
DOI: 10.7483/opendata.cms.nac0.jmfe
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-100cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/5z6cp285gv.1
title: LDHU3_15.1340

description: Succinate dehydrogenase subunit 2C | SDH2C; Leishmania donovani (HU3 strain)
DOI: 10.17632/7k6xtn5w7s.1
title: LDHU3_15.1390

description: SKIP/SNW domain containing protein; Leishmania donovani (HU3 strain)
DOI: 10.7483/opendata.cms.gpmn.m0k9
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-100cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/3798wt5b6g.1
title: LDHU3_15.1330

description: DNA repair protein Rad9; Leishmania donovani (HU3 strain)
DOI: 10.5281/zenodo.14675252
title: Replication Package for: "Market Definition: A Sensitivity Analysis"

description: This replication package contains the code for generating the results reported in "Market Definition: A Sensitivity Analysis" by Paul S. Koh, conditionally accepted in the International Journal of Industrial Organization.

Additionally, the package contains the outputs (tables and figures) generated from the code. 

The package does not contain the main dataset (the 2009 cross-section of Nielsen's Trade Dimensions data), as the terms of use prevent the author from publicly releasing the data.
DOI: 10.7483/opendata.cms.xa3e.qg62
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-100cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.h65t.ajr0
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-100cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.77yh.qxzt
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-10cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.5eqh.vzsc
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-10cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.hjeg.quq7
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-10cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.iwji.qahu
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-10cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.c8fw.mqkh
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-20cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.ubrp.1862
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-20cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/3gwcx9xn9y.1
title: Assessment of bed macrostructuring and thermal wave impact on carbon dioxide adsorption efficiency in a hybrid fixed-bed reactor

description: The dataset supports the paper entitled "Assessment of bed macrostructuring and thermal wave impact on carbon dioxide adsorption efficiency in a hybrid fixed-bed reactor" by M. Gunia, J. Ciećko and K. Bizon (doi: 10.24425/cpe.2023.144699) and it contains:
- mathematical model together with its discretization performed using the method of lines (provided both in docx and pdf file; AD_noniso_1D_model.docx and AD_noniso_1D_model.pdf files, respectively);
- the corresponding numerical script developed in Matlab software (AD_noniso_1D.m file).
DOI: 10.7483/opendata.cms.ulz8.fts0
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-20cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.eau1.ktqn
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-20cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.iz6q.6f5u
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-50cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.fheu.sc65
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-50cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.13e9.m7yy
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-50cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.mkq6.3lae
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-15_ctau-50cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/zyvdx4fcxh.1
title: Untargeted LC-MS/MS-based metabolomics of Ctrl and VIM-overexpressing THP1-derived macrophages

description: Untargeted LC-MS/MS-based metabolomics was applied to Ctrl and VIM-overexpressing THP1-derived macrophages (M0 status), which was done in Novogene company (Bejing, China).
Raw_files-X101SC23122028-Z01-J001-B1-42.zip was the raw results.
Result-X101SC23122028-Z01-J001-B1-42.zip was the routine analyzing results reported by the company.
DOI: 10.7483/opendata.cms.2pu5.xvii
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-0cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.70hp.4aow
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-0cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.c9d8.h9gx
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-0cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.0o0p.nrvq
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-0cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/hr4y2pvy8b.1
title: Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, Against MASLD Progression

description: Background: Progression of metabolic dysfunction associated steatotic liver disease (MASLD) to steatohepatitis (MASH) is driven by stress-inducing lipids that promote liver inflammation and fibrosis, and MASH can lead to cirrhosis and hepatocellular carcinoma. Previously, we showed coordinated defenses regulated by transcription factors, nuclear factor erythroid 2 related fac-tor-1 (Nrf1) and -2 (Nrf2), protect against hepatic lipid stress. Here, we investigated protective effects of hepatocyte Nrf1 and Nrf2 against MASH-linked liver fibrosis and tumorigenesis.

Methods: Male and female mice with flox alleles for genes encoding Nrf1 (Nfe2l1), Nrf2 (Nfe2l2), or both were fed a MASH-inducing diet enriched with high fat, fructose, and cholesterol (HFFC) or control diet for 24-52 weeks. During this period, hepatocyte Nrf1, Nrf2, or combined deficien-cy for ~7-days, ~7-weeks, and ~35-weeks was induced by administering mice hepatocyte target-ing adeno-associated virus (AAV) expressing Cre recombinase. The effect on MASH, markers of liver fibrosis and proliferation, and liver tumorigenesis was compared to control mice receiving AAV expressing green fluorescent protein. Also, to assess the impact of Nrf1 and Nrf2 induction on liver fibrosis, HFFC diet fed C57bl/6J mice received weekly injections of carbon tetrachloride, and from week 16-24, mice were treated with Nrf2 activating drug bardoxolone, hepatocyte overexpression of human NRF1 (hNRF1), or both, and these groups were compared to control.

Results: Compared to control diet, 24-week feeding with HFFC diet increased bodyweight as well as liver weight, steatosis, and inflammation. It also increased hepatocyte proliferation and a marker of liver damage, p62. Hepatocyte Nrf1 and combined deficiency increased liver steatosis in control diet fed but not HFFC diet fed mice, and increased liver inflammation under both diet conditions. Hepatocyte Nrf1 deficiency also increased hepatocyte proliferation, whereas com-bined deficiency did not, and this also occurred for p62 level in control diet fed conditions. In 52-week HFFC diet fed mice, 35 weeks of hepatocyte Nrf1 deficiency, but not combined deficien-cy, resulted in more liver tumors in male mice, but not in female mice. In contrast, hepatocyte Nrf2 deficiency had no effect on any of these parameters. However, in the 15-week CCL4 exposed and 24-week HFFC diet fed mice, Nrf2 induction with bardoxolone reduced liver steatosis, inflam-mation, fibrosis, and proliferation. Induction of hepatic Nrf1 activity with hNRF1 enhanced the effect of bardoxolone on steatosis and may have stimulated liver progenitor cells.

Conclusion: Physiologic Nrf1 delays MASLD progression, Nrf2-induction alleviates MASH, and combined enhancement synergistically protects against steatosis and may facilitate liver re-pair.
DOI: 10.7483/opendata.cms.omzl.pdd1
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-1000cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.ivgy.3etl
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-1000cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.8e6t.24jj
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-1000cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.tads.e1r8
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-1000cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.k5xa.ud0g
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-100cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.h5k3.e55m
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-100cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.nqlo.h7p3
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-100cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.5281/zenodo.14675401
title: O'ZBEKISTONDA ELEKTRON TIJORATNING RIVOJLANISH TENDENSIYALARI
DOI: 10.5281/zenodo.14675402
title: O'ZBEKISTONDA ELEKTRON TIJORATNING RIVOJLANISH TENDENSIYALARI
DOI: 10.7483/opendata.cms.kbhb.y0qh
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-100cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.gb92.pe9d
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-10cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.f7sn.1tfn
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-10cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.17632/8cy65rh8n7.1
title: hydrostatic compression data

description: This excel file contains 6000 sets of compression data. Each set consists of ruby shift and unit-cell volumes of NaCl and Au.
DOI: 10.7483/opendata.cms.sr0l.7dan
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-10cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.7483/opendata.cms.4z7e.oewd
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-10cm_TuneCP5_fixedLifetime_13TeV-powheg-pythia8/RunIISummer20UL16NanoAODv9-106X_mcRun2_asymptotic_v17-v1/NANOAODSIM
DOI: 10.7483/opendata.cms.kujs.yo6s
title: /ZH_ZToLL_HTo2LongLivedTo4G_MH-125_MFF-1_ctau-20cm_TuneCP5_13TeV-powheg-pythia8/RunIISummer20UL16MiniAODv2-106X_mcRun2_asymptotic_v17-v2/MINIAODSIM
DOI: 10.17632/yyyz76tsp5.1
title: Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability

description: Original Western blot images for manuscript figures 5A, 6B, 6F and 6L. Please refer to the published manuscript for all relevant details.
DOI: 10.17632/xy3c2ph3dv.1
title: LDHU3_07.1060

description: DnaJ domain-containing protein | JDP30 | J30
Leishmania donovani (HU3 strain)