cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12851279.v1
title: HuR expression in adipose tissue mediates energy expenditure and acute thermogenesis independent of UCP1 expression

description: The goal of this study was to define the functional role of adipocyte-specific expression of the RNA binding protein Human antigen R (HuR). Mice with an adipocyte-specific deletion of HuR (<i>Adipo-HuR<sup>−/-</sup> </i>) were generated by crossing HuR floxed (<i>HuR<sup>fl/fl</sup> </i>) mice with mice expressing adiponectin-driven cre-recombinase (<i>Adipoq-cre</i>). Our results show that <i>Adipo-HuR<sup>−/-</sup> </i> mice display a lean phenotype compared to wild-type littermate controls. HuR deletion results in a diet-independent reduction in percent body fat composition along with an increase in energy expenditure. Functionally, <i>Adipo-HuR<sup>−/-</sup> </i> mice show a significant impairment in acute adaptive thermogenesis (six hours at 4°C), but uncoupling protein 1 (UCP1) protein expression in brown adipose tissue (BAT) is unchanged compared to control. Pharmacological inhibition of HuR also results in a marked decline in core body temperature following acute cold challenge independent of UCP1 protein expression. Among the 588 HuR-dependent genes in BAT identified by RNA-seq analysis, gene ontology analysis shows a significant enrichment in mediators of calcium transport and signalling, almost all of which are decreased in <i>Adipo-HuR<sup>−/-</sup> </i> mice compared to control. In conclusion, adipocyte expression of HuR plays a central role in metabolic homoeostasis and mediates UCP1-independent thermogenesis in BAT, potentially through post-transcriptional control of intracellular calcium transport.Abbreviations: Adipo-HuR<sup>−/-</sup>: Adipocyte-specific HuR deletion mice; BAT: Brown adipose tissue; HuR: Human antigen R; UCP1: Uncoupling protein 1
DOI: 10.6084/m9.figshare.14619177.v1
title: Replication package

description: <b>Mithra's Replication Package</b><br>In this replication package, we provided <i>Mithra</i> and <i>AR-SI</i>'s implementations, the dataset of 24 bugs on <i>ArduPilot</i> v3.6.9 that we used for evaluation, and 2500 traces of unlabeled training data and 466 evaluation traces (233 erroneous and 233 correct traces). In addition, we provide the dataset of 153 bugs on <i>F1tenth</i> that we used for evaluation, and 75 traces of unlabeled training data and 522 evaluation traces (261 erroneous and 261 correct traces).<br>
DOI: 10.6084/m9.figshare.27020482.v2
title: Effect of infill pattern on the fused deposition modeling (FDM) process in the tensile strength outcomes of ABS polymer

description: Research data from the work "Effect of infill pattern on the fused deposition modeling (FDM) process in the tensile strength outcomes of ABS polymer".
DOI: 10.6084/m9.figshare.27073309.v1
title: Supplementary Material for: Assessing disease control in patients with atopic dermatitis by using the Atopic Dermatitis Control Tool (ADCT) in daily practice

description: Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease, placing a significant burden on patients’ quality of life (QoL). The validated Atopic Dermatitis Control Tool (ADCT) is recommended to assess AD control in adults. The aim of this study is to assess AD control and explore associations with demographic characteristics, patient-reported outcome measures (PROMs), and treatment. 
Methods: In this cross-sectional study, questionnaires were sent to 2066 adults from two tertiary referral centers who had previously physician-diagnosed AD and had visited the outpatient clinic at least once between 2020-2022. Questionnaires were completed between May and October 2022. AD control was assessed by the ADCT, with a score ≥7 indicating uncontrolled AD. AD severity, QoL and weekly average pruritus were simultaneously measured using the Patient-Oriented Eczema Measure (POEM), Dermatology Life Quality Index (DLQI), and Numeric Rating Scale (NRS), respectively, with higher scores indicating more severe symptoms. Moreover, treatment-related questions were included. Associations between uncontrolled AD, age, sex and treatment were explored using multivariate logistic regression analysis.
Results: In total, 863 patients (41.8%) filled out the questionnaire and 812 were included in the analysis, of which 59% reported controlled AD. Uncontrolled AD was associated with higher PROMs scores and receiving topical anti-inflammatories only (adjusted odds ratio (95% confidence interval) ranged from 1.33 (0.995-1.88) to 2.55 (2.21-2.86)). Of those treated with topical anti-inflammatories only, 54% reported uncontrolled AD.
Conclusion: The majority of the patients reported controlled AD. Patients with uncontrolled AD often reported more severe symptoms and were more likely to receive topical anti-inflammatories only. It could be considered to shift patients with uncontrolled AD from topical to systemic treatment.
DOI: 10.6084/m9.figshare.28548674.v1
title: AKR1B1/DAD complexes top-ranked

description: This dataset includes the top-ranked AKR1B1/DAD complex structures obtained through protein-protein docking using ZDOCK, PatchDock, and HADDOCK. The research aims to characterize the binding mode of DAD to AKR1B1 using computational docking approaches. These models serve as starting conformations for further studies. The dataset contributes to understanding the molecular basis of AKR1B1-DAD interactions, providing structural insights for future research.
DOI: 10.6084/m9.figshare.24427243.v1
title: Supplementary Material for: Impairments in Cognitive and Emotional Empathy as Markers of General vs. Specific Personality Pathology

description: Introduction: The alternative model for personality disorders (AMPD) of the Diagnostic and Statistical Manual of Mental Disorders – 5th edition (DSM-5) considers impairments in empathy a basic feature of personality disorders (PDs). In contrast, the AMPD pathological personality trait model and the categorical DSM-5 Section II PD model associate deficits in empathy to specific forms of personality pathology. The present study investigated to what extent impairments in cognitive and emotional empathy are markers of general vs. specific personality pathology. Methods: In the clinical sample (n = 119), the Multifaceted Empathy Test was used to assess cognitive empathy, emotional empathy for positive emotions and emotional empathy for negative emotions. Personality functioning, pathological personality traits, and DSM-5 Section II PDs were assessed via interviews and self-reports. Confirmatory factor analyses were applied to associate the three empathy facets with the three personality pathology approaches, each modelled with general personality pathology (common factor) and specific personality pathology (residuals of indicators). Results: Impairments in cognitive empathy and emotional empathy for positive emotions were significantly correlated with general personality pathology. All three empathy facets were also correlated to specific personality pathology when controlling for general personality pathology, respectively. Impairments in cognitive empathy were incrementally associated to identity and empathy (personality functioning), psychoticism (pathological personality traits), and paranoid and dependent PD (DSM-5 Section II PDs). Deficits in emotional empathy for positive emotions were incrementally associated to self-direction and intimacy (personality functioning) and detachment (pathological personality traits). Impairments in emotional empathy for negative emotions were incrementally associated to antagonism (pathological personality traits) and antisocial PD (DSM-5 Section II PDs). Conclusion: The results suggest that impairments in cognitive empathy and emotional empathy for positive emotions, but not for negative emotions, are markers of general personality pathology, while deficits in the three empathy facets are also markers for specific personality pathology.
DOI: 10.6084/m9.figshare.19932734.v1
title: Supplementary Material for: Regional Cerebral Blood Flow Changes in Healthy Ageing and Alzheimer’s Disease: A Narrative Review

description: <b><i>Background:</i></b> Cerebral blood flow is known to decline with increasing age and is a potential biomarker to distinguish between healthy and unhealthy ageing, where healthy ageing is defined as an absence of comorbidities in senescence. This review aims to synthesize evidence of cerebral blood flow changes over multiple brain regions, for use as a clinical reference or for in silico modelling. <b><i>Summary:</i></b> The search identified 1,087 studies, of which 33 met the inclusion criteria to map the difference in cerebral blood flow reduction between healthy ageing and Alzheimer’s disease. Analysis was also performed on the effect of imaging modality and brain region functionality as potential confounding factors. <b><i>Key Messages:</i></b> No significant difference was found between the specific functionality of a brain region and cerebral blood flow in healthy ageing (<i>p</i> = 0.65) or Alzheimer’s disease (<i>p</i> = 0.42). Arterial spin labelling MRI imaging was shown to measure statistically larger decreases in flow in both healthy ageing (<i>p</i> = 0.0001) and Alzheimer’s disease (<i>p</i> = 0.0465). Cerebral blood flow was shown to decrease 0.3–0.5% per year in healthy ageing, which increased to a decline of 2–5% per year in Alzheimer’s disease. There was large variability both between and within individual brain regions, and this variability increased greatly in Alzheimer’s disease. Future studies would add value by taking more cerebral blood flow measurements during Alzheimer’s disease progression and by investigating ageing with comorbidities such as hypertension.
DOI: 10.6084/m9.figshare.12446120.v1
title: Data on epidemiological and clinical characteristics of coronavirus-infected (COVID-19) individuals in Iran

description: NOTE: there is no peer-reviewed publication associated with this data record.<br><br>This data record contains a single dataset, <b>Statistics200.xls</b>, in .xls file format.<br>The dataset contains information on 1142 patients suspected of having coronavirus. Data collection was performed using interviews, inserting information into the researcher-made questionnaires, and using the information in patients' medical records.<br>The dataset consists of 52 individual variables. Empty cells correspond to data that are not available for that patient. The variables are: age, gender, citizenship, taken to the hospital (1; no, 2; yes), section of hospital, contact coronadisease (0; no history of contact with COVID-19 patients, 1; history of contact with COVID-19 patients), sample for test (0; patient did not provide a sample for the PCR COVID test, 1; patient provided a sample for the PCR test), result PCR (0; negative for COVID-19, 1; positive for COVID-19, 3; test result is pending), The following symptoms were reported, for which 0 stands for absence of symptom, and 1 stands for presence of the symptom: fever, cough, myalgia or fatigue, shortness of breath, loss of consciousness, smell, taste, convulsions, headache, dizziness, limb paresis, limb plexus, chest pain, skin lesions, other signs, gastrointestinal, nausea, vomiting, diarrhea, anorexia), CT scan manifestation (0; CT scan results for COVID-19 are negative, 1; CT scan results for COVID-19 are positive), smoking, use of opium, patient has undergone intubation, rate of partial pressure of oxygen, Po2 (0; PO2 levels are greater than 93, 2; PO2 levels are less than 93), presence of underlying diseases (cancer, liver disease, hematologic disease, diabetes, HIV/AIDS, immune deficiency (acquired or congenital), pregnancy, heart disease, renal disease, dialysis status, asthma, Chronic obstructive pulmonary disease (COPD)), other chronic diseases, hypertension, condition when entering the hospital, death, duration of hospitalisation in days.<br><br><b>Study aims and methodology</b>: The new Coronavirus disease (COVID-19) primarily targets the human respiratory system, and represents a public health emergency and global concern. The present study aimed to investigate the epidemiological and clinical characteristics of COVID-19, in Saveh city, of Iran, in 2020.The present study was descriptive-analytical research in which all 1142 patients suspected of having coronavirus, who visited Saveh Medical Centers from February 9 to April 1 7, 2020, were included in the study. Data collection was performed using interviews, inserting information into the researcher-made questionnaires, and using the information in patients' medical records. Data were analyzed by SPSS 21 using Chi-square, independent sample t tests, Fisher's Exact Test, and regression analysis.For more details on the methodology, please read the related article.<br>
DOI: 10.6084/m9.figshare.14445711.v1
title: iterative DDA neg

description: iterative DDA with PMDDA precursor ions in negative mode<br>
DOI: 10.6084/m9.figshare.14495175.v1
title: Delineating Source Contributions to Stream Dissolved Organic Matter Composition Under Baseflow Conditions in Forested Headwater Catchments

description: Data set used in the study entitled: 'Delineating Source Contributions to Stream Dissolved Organic Matter Composition Under Baseflow Conditions in Forested Headwater Catchments' from da Silva et al. JGR: biogeosciences.
DOI: 10.6084/m9.figshare.28697081.v2
title: Assessment of Biodiversity and Environmental Health in IIEE NCC Adapted Mangrove Plants

description: Mangrove ecosystems serve as vital biodiversity hotspots and natural coastal defenses. However, the presence of macroplastic pollution increasingly threatens their ecological integrity in Southeast Asia, particularly in the Philippines. Despite legislative actions such as the Ecological Solid Waste Management Act (RA 9003) and Extended Producer Responsibility (RA 11898), marine litter persists at alarming levels. Local assessments are necessary to quantify environmental degradation and inform regional action plans. This study assessed the environmental health of the IIEE NCC Adapted Mangrove Plants (IIEENCCAMP) using the Clean Coast Index (CCI) and visual categorization of macroplastics based on the Galarpe and Syakti classification. A total of 103 plastic items were collected and categorized to analyze plastic composition and pollution density. The site scored a CCI of 20.6, categorizing it as “Extremely Dirty.” The most prevalent materials were LDPE (29.13%) and PP (14.56%). These plastics were commonly represented by plastic fragments, bags, and disposable utensils. Variability in item types suggests a combination of domestic waste and localized pollution. Calculated variance and standard deviation of observed plastic categories highlighted a high spread of pollution sources. The findings reveal a pressing need for enhanced waste management and localized intervention. High levels of LDPE and PP waste point to the lack of plastic segregation and community-level awareness. The pollution level in IIEENCCAMP exceeds average coastal cleanliness based on previously reported Assessment of Macro Waste Density and Composition on Residential Coastal Zones in Surigao City, Philippines. Future efforts should include multi-season biodiversity surveys, implementation of localized recycling initiatives, and comparative monitoring of coastal CCI in different barangays. Quantitative metrics like SD and variance should be institutionalized to support targeted environmental policies.
DOI: 10.6084/m9.figshare.6456257.v1
title: Bioclimatic data for the mid-Pliocene Warm Period

description: Bioclimatic data for the mid-Pliocene Warm Period (~3.264-3.025 Ma).
DOI: 10.6084/m9.figshare.4625941.v1
title: Dative Sickness: A Phylogenetic Analysis of Argument Structure Evolution in Germanic (supplementary materials)

description: Supplementary materials to "Dative Sickness: A Phylogenetic Analysis of Argument Structure Evolution in Germanic"
DOI: 10.6084/m9.figshare.7635917.v1
title: data.xlsx

description: The sample contains data for 10 years in sequence, covering the period from 2006 to 2016, the annual data for the indicators considered in the analysis are obtained from the World Bank database. The main independent variable is remittance (REM), which is an aggregate level of personal remittances, received (in current US$). For measuring the level of entrepreneurial activity (ENT), which is dependent variable we used the fraction of registered businesses per economically active inhabitant representing country level data.
DOI: 10.6084/m9.figshare.28485413.v2
title: City air temperature data after basic processingPlease see https://github.com/Alonzo-Lab/urban-temperature-analysis/tree/main for the associated code and instructions for how to run these analyses.

description: Using car-collected air temperature data in 11 northeastern USA cities, we evaluated how land cover at high resolution influences both air and surface temperatures. This dataset is what is required to replicate our primary analyses.
DOI: 10.17632/yfhwk2hs7m.1
title: Kniha - aplikace příkladů

description: Kódy příkladů z knihy v GAMS
DOI: 10.6084/m9.figshare.15156504.v1
title: Supplementary Material for: Alteration of Allergen Fold of Bos d 5 into a Hypoallergenic Vaccine for Immunotherapy of Cow’s Milk Allergy

description: <b><i>Background:</i></b> Cow’s milk allergy (CMA) is the most common IgE-mediated food allergy and Bos d 5 is the major allergen in cow’s milk proteins. More than 60% of the patients with CMA are sensitized to this protein. <b><i>Methods and Results:</i></b> A recombinant protein, encoded by a synthetic gene and consisting of reassembled Bos d 5 fragments, was expressed in <i>E. coli</i> strain BL21 (DE3) cells and purified to homogeneity. The B5M lacked relevant IgE-reactivity and allergenic activity compared with Bos d 5 in dot-blot and basophil activation assays. T-cell proliferation experiments demonstrated that B5M preserved the main T cell epitopes of Bos d 5. Immunization of rabbits with B5M induced protective IgG antibodies that blocked the binding of patients’ IgE antibodies to the wild-type allergen and inhibited the degranulation of basophils induced by Bos d 5. <b><i>Conclusion:</i></b> Thus, we developed a new strategy, which was based on rational molecular reassembly for allergen-specific immunotherapy (AIT) of CMA and food allergy.
DOI: 10.6084/m9.figshare.6795164.v1
title: SealDietData_KKliskaJuly2018.csv

description: <b>Australian for seal data used for the publication " </b><b> </b><b> </b><b>Environmental correlates of temporal variation in the diet of Australian fur seals <i>Arctocephalus pusillus doriferus"</i></b>
DOI: 10.6084/m9.figshare.25521880.v2
title: Occupancy of Roe Deer, Water Deer, and Wild Boar in Wind Farm-Integrated Forest Ecosystems - A Case Study in Korea

description: Understanding the impact of anthropogenic structures on wildlife is essential for balancing ecosystem services. This study explored the impacts of anthropogenic disturbances, particularly wind farms, on South Korean Forest ecosystems utilizing spatial occupancy models and camera trap survey data. We examined the occupancy probability of mammals (roe deer, water deer, and wild boar) around wind farms and identified the influencing factors. The results revealed that roe deer exhibited the highest occupancy probability (0.936), water deer exhibited the lowest (0.503), and wild boar exhibited intermediate values (0.657). For roe deer, the occupancy probability increased with distance from the wind turbine, whereas a high canopy height had a negative impact. Water deer showed a positive correlation with decreasing distance to agricultural land and increasing distance to residential land. Canopy height also contributed positively. Similarly, wild boar displayed a positive association with increased canopy height. Analyzing the impact of wind farm construction time, water deer exhibited a decrease in occupancy probability with more recent construction, whereas wild boars showed the opposite trend. The predicted occupancy probability indicated that roe deer and water deer had the lowest probability near recently built wind farms, whereas wild boar had the highest probability. The results of this study underscore the necessity for continuous monitoring and comprehensive data collection to understand wildlife adaptation mechanisms, avoidance behaviors, and the wind farm forest ecosystem.
DOI: 10.6084/m9.figshare.27761979.v1
title: A sub-meter resolution urban surface albedo dataset for 34 U.S. cities based on deep learning

description: This study presents the first high-resolution urban albedo maps for 34 major U.S. cities using advanced deep learning models on multisource remote sensing data.
DOI: 10.6084/m9.figshare.8869499.v1
title: Supplementary Material for: Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor

description: <b><i>Background:</i></b> The combination of capecitabine (CAP) with temozolomide (TEM) chemotherapy in advanced pancreatic neuroendocrine tumors (PanNET) relies on limited evidence. We compared TEM-CAP to TEM alone in patients with advanced PanNET. <b><i>Methods:</i></b> Consecutive patients with advanced PanNET treated with TEM or TEM-CAP between 2004 and 2017 in three expert centers were included. Progression-free survival (PFS), tolerance, tumor response, and overall survival were compared between the two groups. Propensity-based analyses were performed to reduce confounding bias due to the nonrandomized setting. <b><i>Results:</i></b> TEM and TEM-CAP were administered to 38 patients and 100 patients, respectively, with a median age of 58 years. The patients in the TEM group more often had hormonal syndromes (<i>p</i> = 0.03), a longer median delay to diagnosis (<i>p</i> = 0.001), and a higher number of pretreatment lines (<i>p</i> &lt; 0.001). The performance status was 0 in 58% versus 65% of the patients, and tumor’s median Ki-67 index was 8% versus 11%, respectively. Tolerance was similar, except that there were more cases of asthenia in the TEM group (<i>p</i> = 0.017) and more cases of hand-foot syndrome in the TEM-CAP group (<i>p</i> = 0.025). The objective response rate was 34% versus 51% (<i>p</i> = 0.088). The raw median PFS was similar with TEM and with TEM-CAP (21.4 vs. 19.8 months, <i>p</i> = 0.84). Although CAP tended to decrease the risk of progression in Cox multivariate analysis (HR 0.65, <i>p</i> = 0.12), it had no effect after adjustment for the propensity score (HR 1.06, <i>p</i> = 0.80). <b><i>Conclusions:</i></b> TEM-CAP might not prolong PFS but might achieve a higher response rate than TEM alone. Hence, TEM-CAP might be preferred when tumor shrinkage is the main therapeutic objective. Otherwise, TEM might be adequate for patients with an impaired performance status or in case of extrahepatic metastases.
DOI: 10.6084/m9.figshare.28829771.v1
title: STGAT-VCA 的数据集和模型代码：与图注意力网络和门控循环单元集成的矢量元胞自动机模型，用于城市土地利用变化模拟。

description: 这是 STGAT-VCA 模型的数据集和模型代码。
DOI: 10.6084/m9.figshare.5924797.v2
title: Merge script

description: Script in R language to load the databases and merge them into an unique file. This script may be modified and extended as needed.