cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4810459.v1
title: New putative cryptic species detection and genetic network analysis of <i>Bemisia tabaci</i> (Hempitera: Aleyrodidae) in China based on mitochondrial COI sequences

description: The whitefly <i>Bemisia tabaci</i> (Gennadius) (Hemiptera: Aleyrodidae) is a cryptic species complex and widely distributed throughout tropical and subtropical regions. To understand the <i>B. tabaci</i> cryptic species diversity in China more comprehensively, in the year 2014 and 2016, a large-scale sampling was conducted from the famous biodiversity hotspot of China, Yunnan province. Mitochondrial cytochrome oxidase I gene sequences were used to identify new putative cryptic species. Phylogenetic analyses were performed using Bayesian methods to evaluate the position of new cryptic species in the context of the <i>B. tabaci</i> diversity in Asia. Two new cryptic species, China 5 and Asia V were identified. In total, 19 <i>B. tabaci</i> cryptic species are present in China, two invasive (MED and MEAM1) and 17 indigenous. A new sibling species of <i>B. tabaci</i> was first defined and reported. Based on the mtCOI sequences and haplotype network analyses, the genetic diversity of MED was far higher than MEAM1. We confirmed the exotic MED was originated from the western Mediterranean regions and first invaded into Yunnan, China. The genetic structures of other four indigenous species (Asia I, Asia II 1, Asia II 6, and China 1) with relatively wide distribution ranges in China were also discussed.
DOI: 10.6084/m9.figshare.4810852
title: Determination of air pollution-related biomarkers of exposure in urine of travellers between Germany and China using liquid chromatographic and liquid chromatographic-mass spectrometric methods: a pilot study

description: <b>Objective:</b> The influence of different exposures to PM<sub>2.5</sub> (particulate matter with an aerodynamic diameter below 2.5 μm) on the concentrations of biomarkers of exposure and oxidative stress should be investigated. For this purpose, urine samples from individuals travelling from Germany to China were collected and analysed. <b>Materials:</b> Robust LC and LC-MS/MS methods were established for the determination of biomarkers including 8-hydroxy-2′-deoxyguanosine, malondialdehyde, F<sub>2α</sub>-isoprostanes and hydroxylated polycyclic aromatic hydrocarbons. As a pilot study, nine volunteers travelled from Germany (mean daily concentration of PM<sub>2.5</sub>: 21 μg/m<sup>3</sup>) to China (mean daily concentration of PM<sub>2.5</sub>: 108 μg/m<sup>3</sup>). Urine samples were collected before and after the trip. <b>Results:</b> In samples collected after return to Germany, the median concentrations of oxidative stress biomarkers were observed to be higher than in samples collected before leaving Germany. Decreasing trends were observed in the sequences of samples collected after return in the following weeks. Correlations were found between exposure and oxidative stress biomarkers. <b>Conclusion:</b> Travellers are ideal models for PM pollution-induced acute health effects study. Exposure to PM pollution can cause oxidative stress and damage.
DOI: 10.6084/m9.figshare.4810852.v1
title: Determination of air pollution-related biomarkers of exposure in urine of travellers between Germany and China using liquid chromatographic and liquid chromatographic-mass spectrometric methods: a pilot study

description: <b>Objective:</b> The influence of different exposures to PM<sub>2.5</sub> (particulate matter with an aerodynamic diameter below 2.5 μm) on the concentrations of biomarkers of exposure and oxidative stress should be investigated. For this purpose, urine samples from individuals travelling from Germany to China were collected and analysed. <b>Materials:</b> Robust LC and LC-MS/MS methods were established for the determination of biomarkers including 8-hydroxy-2′-deoxyguanosine, malondialdehyde, F<sub>2α</sub>-isoprostanes and hydroxylated polycyclic aromatic hydrocarbons. As a pilot study, nine volunteers travelled from Germany (mean daily concentration of PM<sub>2.5</sub>: 21 μg/m<sup>3</sup>) to China (mean daily concentration of PM<sub>2.5</sub>: 108 μg/m<sup>3</sup>). Urine samples were collected before and after the trip. <b>Results:</b> In samples collected after return to Germany, the median concentrations of oxidative stress biomarkers were observed to be higher than in samples collected before leaving Germany. Decreasing trends were observed in the sequences of samples collected after return in the following weeks. Correlations were found between exposure and oxidative stress biomarkers. <b>Conclusion:</b> Travellers are ideal models for PM pollution-induced acute health effects study. Exposure to PM pollution can cause oxidative stress and damage.
DOI: 10.6084/m9.figshare.4813972
title: Costs, Trends, and Related Factors in Treating Lung Cancer Patients in 67 Hospitals in Guangxi, China

description: Lung cancer is a common disease with high mortality in China. Recent economic advances have led to improved medical capabilities, while costs associated with treating this disease have increased. Such change contributes to a commonly held belief that healthcare costs are out of control. However, few studies have examined this issue. Here, we use 34,678 hospitalization summary reports from 67 Guangxi hospitals (period 2013–2016) to document costs, temporal trends, and associated factors. Findings from this study are surprising in that they debunk the myth of uncontrolled healthcare costs. In addition, results and experiences from Guangxi are informative for other comparable regions.
DOI: 10.6084/m9.figshare.4813972.v1
title: Costs, Trends, and Related Factors in Treating Lung Cancer Patients in 67 Hospitals in Guangxi, China

description: Lung cancer is a common disease with high mortality in China. Recent economic advances have led to improved medical capabilities, while costs associated with treating this disease have increased. Such change contributes to a commonly held belief that healthcare costs are out of control. However, few studies have examined this issue. Here, we use 34,678 hospitalization summary reports from 67 Guangxi hospitals (period 2013–2016) to document costs, temporal trends, and associated factors. Findings from this study are surprising in that they debunk the myth of uncontrolled healthcare costs. In addition, results and experiences from Guangxi are informative for other comparable regions.
DOI: 10.6084/m9.figshare.4818025
title: Ordovician sedimentation and bimodal volcanism in the Southern Qiangtang terrane of northern Tibet: Implications for the evolution of the northern Gondwana margin

description: This article reports our new interpretations of the depositional environment and provenance of the Dawashan Formation in the Longmuco–Shuanghu–Lancangjiang suture zone (LSLSZ), in the Southern Qiangtang terrane of northern Tibet, in order to gain a better understanding of the Ordovician tectonic evolution of the northern margin of Gondwana. The Dawashan Formation is dominated by greywacke and shale, with interlayered bimodal volcanic rocks that were deposited in a bathyal to abyssal marine basin. The detrital zircons in the greywacke of the Dawashan Formation have peak ages of 550, 988, 1640, and 2500 Ma, indicating a northern Gondwana margin provenance. The bimodal metavolcanic rocks from the Dawashan Formation are dominated by metarhyolite with subordinate metabasalt. The results of zircon LA-ICP-MS U–Pb dating indicate that the metarhyolite formed between 470 and 455 Ma. The metavolcanic samples are bimodal (SiO<sub>2</sub> = 45.27–55.05 and 66.09–74.59 wt.%). In comparison, the metabasalt has a wide range of MgO concentrations and Mg<sup>#</sup> values, contains variable Cr and low Ni concentrations, is depleted in Rb, Ba, and Sr, and is enriched in TiO<sub>2</sub>, Th, U, Nb, and Ta. Geochemical diagrams show that the metabasalt erupted in an intra-plate environment. The metarhyolites have high SiO<sub>2</sub>, Th, and U concentrations, low concentrations of MgO, P<sub>2</sub>O<sub>5</sub>, Nb, Sr, and Ti, and negative Eu anomalies. The metarhyolites yield negative zircon <i>ε</i><sub>Hf</sub>(<i>t</i>) values (–2.08 to – 4.50) and T<sup>C</sup><sub>DM</sub> model ages of 1436–1567 Ma. The metarhyolites formed from magma derived from the partial melting of old continental crust. These data indicate that the Dawashan Formation records Middle–Upper Ordovician bathyal to abyssal turbidite deposition in a deep-water rift basin at the northern margin of Gondwana.
DOI: 10.6084/m9.figshare.4818025.v1
title: Ordovician sedimentation and bimodal volcanism in the Southern Qiangtang terrane of northern Tibet: Implications for the evolution of the northern Gondwana margin

description: This article reports our new interpretations of the depositional environment and provenance of the Dawashan Formation in the Longmuco–Shuanghu–Lancangjiang suture zone (LSLSZ), in the Southern Qiangtang terrane of northern Tibet, in order to gain a better understanding of the Ordovician tectonic evolution of the northern margin of Gondwana. The Dawashan Formation is dominated by greywacke and shale, with interlayered bimodal volcanic rocks that were deposited in a bathyal to abyssal marine basin. The detrital zircons in the greywacke of the Dawashan Formation have peak ages of 550, 988, 1640, and 2500 Ma, indicating a northern Gondwana margin provenance. The bimodal metavolcanic rocks from the Dawashan Formation are dominated by metarhyolite with subordinate metabasalt. The results of zircon LA-ICP-MS U–Pb dating indicate that the metarhyolite formed between 470 and 455 Ma. The metavolcanic samples are bimodal (SiO<sub>2</sub> = 45.27–55.05 and 66.09–74.59 wt.%). In comparison, the metabasalt has a wide range of MgO concentrations and Mg<sup>#</sup> values, contains variable Cr and low Ni concentrations, is depleted in Rb, Ba, and Sr, and is enriched in TiO<sub>2</sub>, Th, U, Nb, and Ta. Geochemical diagrams show that the metabasalt erupted in an intra-plate environment. The metarhyolites have high SiO<sub>2</sub>, Th, and U concentrations, low concentrations of MgO, P<sub>2</sub>O<sub>5</sub>, Nb, Sr, and Ti, and negative Eu anomalies. The metarhyolites yield negative zircon <i>ε</i><sub>Hf</sub>(<i>t</i>) values (–2.08 to – 4.50) and T<sup>C</sup><sub>DM</sub> model ages of 1436–1567 Ma. The metarhyolites formed from magma derived from the partial melting of old continental crust. These data indicate that the Dawashan Formation records Middle–Upper Ordovician bathyal to abyssal turbidite deposition in a deep-water rift basin at the northern margin of Gondwana.
DOI: 10.6084/m9.figshare.4818325
title: Palaeogene Sediment-hosted Pb–Zn deposits in SE Asia: the Uragen example

description: The strata-bound Pb–Zn deposits in western China share many similarities and are controversial in genesis. The large Uragen Pb–Zn deposit is located in the northwestern part of the Kashgar sag, southwest of Tarim Basin, Xinjiang, NW China. With the 980.9 Mt tons of Pb–Zn ores at 0.45%Pb and 2.61%Zn, it is the third largest known Pb–Zn deposits in China. The orebodies are stratiform and stratabound and are predominantly controlled by the Uragen syncline that has an E–W axial trend. Mineralization mostly occurs in sandstones and conglomerates of the Lower Cretaceous Kezilesu Group (K<sub>1</sub><i>kz</i>), with a small amount in the Palaeocene limestone. The main ore types consist predominantly of disseminated ore with minor massive ore, veined ore, and breccia ore. The primary metal minerals are composed of sphalerite, galena, pyrite, and minor arsenopyrite and chalcopyrite, and the supergene metal minerals include smithsonite, cegamite, beudantite, jarosite, limonite, and minor hemimorphite. The gangue minerals are composed of dolomite, calcite, quartz, celestite, and gypsium. Our new Rb–Sr isotopic analyses on the separated sphalerite, galena yielded an isochron age of 55.1 ± 1.6 Ma, coeval to an isochron age of 55.4 ± 2.2 Ma by Sm–Nd isotopic data. This age is much younger than the youngest ore-bearing strata (E<sub>1</sub><sup>1</sup>, 65.5–61.7 Ma), arguing for an epigenetic origin. The calculated initial <sup>87</sup>Sr/<sup>86</sup>Sr ratio of sulphides is 0.710322, which is much lower than those of basement formation, regional bituminous sandstone, and even the ore-bearing strata, but higher than the regional mantle-derived, alkaline volcanic rocks and marine carbonate. The calculated initial <sup>143</sup>Nd/<sup>144</sup>Nd ratio of calcite and galena is 0.512081. These data suggest that the metals may be chiefly derived from crust, possibly from the minor contribution of mantle materials. Our new-age data, in combination with the previous data, suggest that there probably is a huge medium-low-temperature epigenetic stratabound Pb–Zn belt, which is possibly correlated to the India–Asia collision event.
DOI: 10.6084/m9.figshare.4818325.v1
title: Palaeogene Sediment-hosted Pb–Zn deposits in SE Asia: the Uragen example

description: The strata-bound Pb–Zn deposits in western China share many similarities and are controversial in genesis. The large Uragen Pb–Zn deposit is located in the northwestern part of the Kashgar sag, southwest of Tarim Basin, Xinjiang, NW China. With the 980.9 Mt tons of Pb–Zn ores at 0.45%Pb and 2.61%Zn, it is the third largest known Pb–Zn deposits in China. The orebodies are stratiform and stratabound and are predominantly controlled by the Uragen syncline that has an E–W axial trend. Mineralization mostly occurs in sandstones and conglomerates of the Lower Cretaceous Kezilesu Group (K<sub>1</sub><i>kz</i>), with a small amount in the Palaeocene limestone. The main ore types consist predominantly of disseminated ore with minor massive ore, veined ore, and breccia ore. The primary metal minerals are composed of sphalerite, galena, pyrite, and minor arsenopyrite and chalcopyrite, and the supergene metal minerals include smithsonite, cegamite, beudantite, jarosite, limonite, and minor hemimorphite. The gangue minerals are composed of dolomite, calcite, quartz, celestite, and gypsium. Our new Rb–Sr isotopic analyses on the separated sphalerite, galena yielded an isochron age of 55.1 ± 1.6 Ma, coeval to an isochron age of 55.4 ± 2.2 Ma by Sm–Nd isotopic data. This age is much younger than the youngest ore-bearing strata (E<sub>1</sub><sup>1</sup>, 65.5–61.7 Ma), arguing for an epigenetic origin. The calculated initial <sup>87</sup>Sr/<sup>86</sup>Sr ratio of sulphides is 0.710322, which is much lower than those of basement formation, regional bituminous sandstone, and even the ore-bearing strata, but higher than the regional mantle-derived, alkaline volcanic rocks and marine carbonate. The calculated initial <sup>143</sup>Nd/<sup>144</sup>Nd ratio of calcite and galena is 0.512081. These data suggest that the metals may be chiefly derived from crust, possibly from the minor contribution of mantle materials. Our new-age data, in combination with the previous data, suggest that there probably is a huge medium-low-temperature epigenetic stratabound Pb–Zn belt, which is possibly correlated to the India–Asia collision event.
DOI: 10.6084/m9.figshare.4828639
title: TUG1-miR590-5p-PBRM1 contribute to the development of clear cell renal cell carcinoma

description: Four most frequently
mutation genes can distinct ccRCC from other tumor. UG1 and has-miR590-5p in
regulating PBRM1 RNA expression contribute to the development of ccRCC.
DOI: 10.6084/m9.figshare.4828639.v1
title: TUG1-miR590-5p-PBRM1 contribute to the development of clear cell renal cell carcinoma

description: Four most frequently
mutation genes can distinct ccRCC from other tumor. UG1 and has-miR590-5p in
regulating PBRM1 RNA expression contribute to the development of ccRCC.
DOI: 10.6084/m9.figshare.4869053
title: UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures

description: The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing protein 1 (UHRF1) plays an important role in the maintenance of 5mC levels. Loss of UHRF1 abolishes 5mC in cells and leads to embryonic lethality in mice. Interestingly, UHRF1 has a paralog, UHRF2, that has similar sequence and domain architecture, but its biologic function is not clear. Here, we have generated <i>Uhrf2</i> knockout mice and characterized the role of UHRF2 <i>in vivo. Uhrf2</i> knockout mice are viable, but the adult mice develop frequent spontaneous seizures and display abnormal electrical activities in brain. Despite no global DNA methylation changes, 5mC levels are decreased at certain genomic loci in the brains of <i>Uhrf2</i> knockout mice. Therefore, our study has revealed a unique role of UHRF2 in the maintenance of local 5mC levels in brain that is distinct from that of its paralog UHRF1.
DOI: 10.6084/m9.figshare.4869053.v1
title: UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures

description: The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing protein 1 (UHRF1) plays an important role in the maintenance of 5mC levels. Loss of UHRF1 abolishes 5mC in cells and leads to embryonic lethality in mice. Interestingly, UHRF1 has a paralog, UHRF2, that has similar sequence and domain architecture, but its biologic function is not clear. Here, we have generated <i>Uhrf2</i> knockout mice and characterized the role of UHRF2 <i>in vivo. Uhrf2</i> knockout mice are viable, but the adult mice develop frequent spontaneous seizures and display abnormal electrical activities in brain. Despite no global DNA methylation changes, 5mC levels are decreased at certain genomic loci in the brains of <i>Uhrf2</i> knockout mice. Therefore, our study has revealed a unique role of UHRF2 in the maintenance of local 5mC levels in brain that is distinct from that of its paralog UHRF1.
DOI: 10.6084/m9.figshare.4871687
title: Clustalw alignment for phylogenetic analysis of HT-58-2Cyano

description: Phylip formatted output of ClustalW aligned 16S rRNA of HT-58-2Cyano and other cyanobacteria. Supporting data for the manuscript AEM01068-17 submitted to Applied and Environmental Microbiology.
DOI: 10.6084/m9.figshare.4871687.v1
title: Clustalw alignment for phylogenetic analysis of HT-58-2Cyano.phy

description: Phylip formatted output of ClustalW aligned 16S rRNA of HT-58-2Cyano and other cyanobacteria. Supporting data for the manuscript AEM01068-17 submitted to Applied and Environmental Microbiology.
DOI: 10.6084/m9.figshare.4871687.v2
title: Clustalw alignment for phylogenetic analysis of HT-58-2Cyano.phy

description: Phylip formatted output of ClustalW aligned 16S rRNA of HT-58-2Cyano and other cyanobacteria. Supporting data for the manuscript AEM01068-17 submitted to Applied and Environmental Microbiology.
DOI: 10.6084/m9.figshare.4871687.v3
title: Clustalw alignment for phylogenetic analysis of HT-58-2Cyano

description: Phylip formatted output of ClustalW aligned 16S rRNA of HT-58-2Cyano and other cyanobacteria. Supporting data for the manuscript AEM01068-17 submitted to Applied and Environmental Microbiology.
DOI: 10.6084/m9.figshare.4873430
title: Genome survey and characterization of reproduction-related genes in the Pacific oyster

description: Reproductive mechanisms in molluscs have been targets for biological research because of the diverse reproductive strategies exhibited in this phylum. However, little is known about the molecular mechanisms of molluscan reproduction. The whole genome sequence of the Pacific oyster <i>Crassostrea gigas</i> together with the transcriptomic data-sets provides a powerful platform for studies on the characterization of the genes involved in bivalve reproduction. Reproduction-related genes were screened in this study through analyzing the Pacific oyster genome. Previously identified molluscan reproduction-related genes were used as queries to a BLASTP search against the <i>C. gigas</i> genome to identify gene candidates encoding similar proteins. Transcriptomic data-sets were analyzed to profile gene candidate expression patterns. We obtained 39 gene candidates with high accuracy encoding reproduction-related genes in the <i>C. gigas</i> genome, of which 17 are reported in detail, and the rest are identified as new candidate genes involved in reproduction of <i>C. gigas,</i> including <i>nanos</i>, <i>piwi</i>, <i>dax1</i>, and <i>5</i>-<i>hydroxytryptamine</i> (<i>5</i>-<i>HT</i>) receptors. Among 22 gene candidates, seven were gonad-specifically expressed. The set of reproduction-related genes of <i>C. gigas</i> identified in this study constitutes a new tool for further research on molecular mechanisms of reproduction in <i>C. gigas</i>.
DOI: 10.6084/m9.figshare.4873430.v1
title: Genome survey and characterization of reproduction-related genes in the Pacific oyster

description: Reproductive mechanisms in molluscs have been targets for biological research because of the diverse reproductive strategies exhibited in this phylum. However, little is known about the molecular mechanisms of molluscan reproduction. The whole genome sequence of the Pacific oyster <i>Crassostrea gigas</i> together with the transcriptomic data-sets provides a powerful platform for studies on the characterization of the genes involved in bivalve reproduction. Reproduction-related genes were screened in this study through analyzing the Pacific oyster genome. Previously identified molluscan reproduction-related genes were used as queries to a BLASTP search against the <i>C. gigas</i> genome to identify gene candidates encoding similar proteins. Transcriptomic data-sets were analyzed to profile gene candidate expression patterns. We obtained 39 gene candidates with high accuracy encoding reproduction-related genes in the <i>C. gigas</i> genome, of which 17 are reported in detail, and the rest are identified as new candidate genes involved in reproduction of <i>C. gigas,</i> including <i>nanos</i>, <i>piwi</i>, <i>dax1</i>, and <i>5</i>-<i>hydroxytryptamine</i> (<i>5</i>-<i>HT</i>) receptors. Among 22 gene candidates, seven were gonad-specifically expressed. The set of reproduction-related genes of <i>C. gigas</i> identified in this study constitutes a new tool for further research on molecular mechanisms of reproduction in <i>C. gigas</i>.
DOI: 10.34740/kaggle/dsv/7932337
title: Daily Public Opinion on Israel-Palestine War