cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6967601
title: The diagnostic value of FNDC5/Irisin in renal Cell Cancer

description: ABSTRACT Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were &gt;105pg/mL and CEA were &gt;2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
DOI: 10.6084/m9.figshare.6967604
title: MAPPING OF THE BRAZILIAN SCIENTIFIC PUBLICATION ON FACILITY LOCATION

description: ABSTRACT Mathematical models are relevant to indicate the optimal location of facilities and, consequently, help in the search for efficiency in the supply chain. Although facility location problems are consolidated in the Operational Research field, few publications are dedicated to investigate the profile of the academic production (the amount of paper published), aiming to direct new studies on the subject and propose models that solve the current challenges. Thus, this paper aims to present a scientometric analysis of the articles on facility location published in the Web of Science, in order to verify the profile of Brazilian scientific production. As result, approximately 2% of the papers have researchers affiliated to Brazilian institutions. The interest for the subject is recent, with emphasis on universities. Brazil maintains an intense international collaboration network, cooperating with 45 different countries, especially USA. Finally, there is opportunity for publications that include the environmental dimention to mathematical models and for expansion in company-university-government collaboration.
DOI: 10.6084/m9.figshare.6967598
title: Are uroflowmetry and post - void residual urine tests necessary in children with primary nocturnal enuresis?

description: ABSTRACT Objectives: To examine the benefits of repetitive uroflowmetry and post void residual urine (PVR) tests in children with primary nocturnal enuresis (PNE). Material and methods: Children aged ≥6 years with PNE who visited our clinics for management of enuresis were included for study. Patients were requested to complete a questionnaire including baseline characteristics and Dysfunctional Voiding Symptom Score (DVSS), 2-day bladder diary, and Rome III criteria for constipation. Two uroflowmetry and PVR tests were requested. Children with congenital or neurogenic genitourinary tract disorders were excluded. All children underwent urotherapy and desmopressin combined with anticholinergics or laxatives if indicated. The definition of abnormal flow patterns (≥1 abnormal), elevated PVR (≥1 abnormal), small maximal voided volume (MVV), nocturnal polyuria (NP) and response to treatment complied with the ICCS standardization document. Kaplan-Meier survival analysis and Cox proportional-hazards regression tests were used to evaluate the predictors of response. Results: In total, 100 children aged 8.5±2.3 years were enrolled for study (M: F=66:34) with 7.3±7.4 months of follow-up. Poor correlation was observed between DVSS/small MVV and PVR (p&gt;0.05). Univariate analysis revealed that elevated PVR is associated with significantly less hazard of complete response to medical treatment (HR: 0.52, p=0.03), while not significantly associated with abnormal flow patterns, NP, constipation or small MVV. Multivariate analysis revealed that only elevated PVR (HR 0.30, 95% CI 0.12-0.80) and NP (HR 2.8, 95% CI 1.10-7.28) were significant predictors for complete response. Conclusions: In managing pediatric enuresis, elevated PVR is a significant predictor for lower chance of complete response to treatment whether they had high DVSS or not.
DOI: 10.6084/m9.figshare.6967601.v1
title: The diagnostic value of FNDC5/Irisin in renal Cell Cancer

description: ABSTRACT Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were &gt;105pg/mL and CEA were &gt;2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
DOI: 10.6084/m9.figshare.6967604.v1
title: MAPPING OF THE BRAZILIAN SCIENTIFIC PUBLICATION ON FACILITY LOCATION

description: ABSTRACT Mathematical models are relevant to indicate the optimal location of facilities and, consequently, help in the search for efficiency in the supply chain. Although facility location problems are consolidated in the Operational Research field, few publications are dedicated to investigate the profile of the academic production (the amount of paper published), aiming to direct new studies on the subject and propose models that solve the current challenges. Thus, this paper aims to present a scientometric analysis of the articles on facility location published in the Web of Science, in order to verify the profile of Brazilian scientific production. As result, approximately 2% of the papers have researchers affiliated to Brazilian institutions. The interest for the subject is recent, with emphasis on universities. Brazil maintains an intense international collaboration network, cooperating with 45 different countries, especially USA. Finally, there is opportunity for publications that include the environmental dimention to mathematical models and for expansion in company-university-government collaboration.
DOI: 10.6084/m9.figshare.6967598.v1
title: Are uroflowmetry and post - void residual urine tests necessary in children with primary nocturnal enuresis?

description: ABSTRACT Objectives: To examine the benefits of repetitive uroflowmetry and post void residual urine (PVR) tests in children with primary nocturnal enuresis (PNE). Material and methods: Children aged ≥6 years with PNE who visited our clinics for management of enuresis were included for study. Patients were requested to complete a questionnaire including baseline characteristics and Dysfunctional Voiding Symptom Score (DVSS), 2-day bladder diary, and Rome III criteria for constipation. Two uroflowmetry and PVR tests were requested. Children with congenital or neurogenic genitourinary tract disorders were excluded. All children underwent urotherapy and desmopressin combined with anticholinergics or laxatives if indicated. The definition of abnormal flow patterns (≥1 abnormal), elevated PVR (≥1 abnormal), small maximal voided volume (MVV), nocturnal polyuria (NP) and response to treatment complied with the ICCS standardization document. Kaplan-Meier survival analysis and Cox proportional-hazards regression tests were used to evaluate the predictors of response. Results: In total, 100 children aged 8.5±2.3 years were enrolled for study (M: F=66:34) with 7.3±7.4 months of follow-up. Poor correlation was observed between DVSS/small MVV and PVR (p&gt;0.05). Univariate analysis revealed that elevated PVR is associated with significantly less hazard of complete response to medical treatment (HR: 0.52, p=0.03), while not significantly associated with abnormal flow patterns, NP, constipation or small MVV. Multivariate analysis revealed that only elevated PVR (HR 0.30, 95% CI 0.12-0.80) and NP (HR 2.8, 95% CI 1.10-7.28) were significant predictors for complete response. Conclusions: In managing pediatric enuresis, elevated PVR is a significant predictor for lower chance of complete response to treatment whether they had high DVSS or not.
DOI: 10.6084/m9.figshare.6967583
title: Description, modeling and simulation of the congested link of a university

description: Abstract This paper presents a performance evaluation study of a congested communication network in a university. Queuing often occurs in this network due to high demand and disposal of requests at peak times, resulting directly in decreased service quality for its users, who have their connections delayed or interrupted and cannot access the web pages. The goal of the present work was to characterize this congestion problem empirically, capturing packet traces in logs and studying delays and losses, and to model and analyze this system based on the queuing theory and discrete event simulation to evaluate its performance, identify bottlenecks and proposing solutions to improve the quality of service. The study showed that, in situations of peak traffic, simulation was the quantitative approach that produced results closer to the empirical ones, as the analytical queuing models studied did not provide good approximations, mostly by not reflecting the control exercised by the Transmission Control Protocol (TCP).
DOI: 10.6084/m9.figshare.6967583.v1
title: Description, modeling and simulation of the congested link of a university

description: Abstract This paper presents a performance evaluation study of a congested communication network in a university. Queuing often occurs in this network due to high demand and disposal of requests at peak times, resulting directly in decreased service quality for its users, who have their connections delayed or interrupted and cannot access the web pages. The goal of the present work was to characterize this congestion problem empirically, capturing packet traces in logs and studying delays and losses, and to model and analyze this system based on the queuing theory and discrete event simulation to evaluate its performance, identify bottlenecks and proposing solutions to improve the quality of service. The study showed that, in situations of peak traffic, simulation was the quantitative approach that produced results closer to the empirical ones, as the analytical queuing models studied did not provide good approximations, mostly by not reflecting the control exercised by the Transmission Control Protocol (TCP).
DOI: 10.6084/m9.figshare.6967571
title: Sediment examination of urine without physical-chemical alterations

description: ABSTRACT Introduction: It is from the urine sediment examination that many conclusions are drawn by the professional responsible for diagnosis. Because that is a test frequently run in laboratories, it is desirable to reduce costs and time to exam sediment in urine samples considered normal. Objectives: To evaluate the importance of sediment microscopy in urine without physical and chemical alterations. Material and method: This is an epidemiological study of a cross-sectional design developed at a college laboratory based on reports of urine tests performed from January to July, 2017. For comparison between means, Student's t-test, Pearson's chi-square test and Spearman's correlation were done. The level of significance was 5%. Results: We analyzed 7,734 urine reports, with 2,530 (32.7%) results without physical-chemical changes. Patients had a mean age of 39 (± 23) years, most of them were males (61.7%). Regarding leukocyte quantification, 2.3% of the patients had a number higher than the reference values, and in relation to red blood cells, 1.7% of the patients exceeded these values. It was observed that the amount of leukocytes found in the urine specimens without physical-chemical alterations (p &lt; 0.007) was reduced by 0.4 with each year of age. Conclusion: From the data of the present study, one can conclude that the majority of patients without physical-chemical changes do not have any changes of clinical relevance in sediment analysis.
DOI: 10.6084/m9.figshare.6967574
title: Circumcision: postoperative complications that required reoperation

description: ABSTRACT Objective To evaluate post-operative complications of circumcision requiring surgical reintervention. Methods Retrospective analysis of medical records of patients submitted to circumcision from May 1st, 2015 to May 31st, 2016. Results A total of 2,441 circumcisions were performed; in that, 1,940 using Plastibell and 501 by the classic technique. Complications requiring surgical reintervention were found in 3.27% of patients. When separated by surgical technique, 3.4% of circumcisions using Plastibell device required reoperation, as compared to 3% of conventional technique (p=0.79). Preputial stenosis was most frequently found in classic circumcision, with statistical significance (p&lt;0.001). Bleeding was more frequent when using Plastibell device, but the difference was not statistically different (p=0.37). Patients’ age was also evaluated to investigate if this variable influenced on the postoperative outcome, but no significant difference was found. Conclusion There was no statistically significant difference when comparing complications between the different techniques performed at this hospital. Preputial stenosis was most frequently found in the classic circumcision, while bleeding was more prevalent when using Plastibell device. Patients’ age did not influence in complications.
DOI: 10.6084/m9.figshare.6967568
title: Barriers and challenges to improve interfunctional integration between Product Development and Production Planning and Control in Engineering-to-Order Environment

description: Abstract Interfunctional integration is indicated by several studies as an alternative to increased operational excellence, improving organizational performance through improved interaction and collaboration in organizational processes. The focus of this paper is to present and discuss barriers and challenges to improve interfunctional integration between Product Development (PD) and Production Planning and Control (PPC) in production systems that adopt the strategy of response to demand Engineering-to-Order (ETO). To reach that goal, we used a literature review on the topics of interest and findings obtained from the case studies of three large metal mechanical companies that design and manufacture customized-made capital goods. The following were observed as main results: barriers and challenges related to the interaction between functional areas during the process of order fulfillment, and the need for actions that seek to improve the interaction and collaboration between PD and PPC, taking into account the peculiarities of the ETO environment.
DOI: 10.6084/m9.figshare.6967565
title: Quality of life and cochlear implant: results in adults with postlingual hearing loss

description: Abstract Introduction Considering the variability of results found in the clinical population using a cochlear implant, researchers in the area have been interested in the inclusion of quality of life measures to subjectively assess the benefits of the implantation. Objective To assess the quality of life of adult users of cochlear implant. Methods A cross-sectional and clinical study in a group of 26 adults of both genders, with mean duration of cochlear implant use of 6.6 years. The Nijmegen Cochlear Implantation Questionnaire and the generic World Health Organization Quality of Life questionnaire were sent electronically. Results The best assessed domain in the quality of life assessment for the cochlear implantation questionnaire was the social domain, whereas for the quality of life questionnaire it was the psychological domain. The variables, gender, time of cochlear implant use and auditory modality did not influence the results of both questionnaires. Only the variable level of education was correlated with the environment domain of the quality of life questionnaire. The variable telephone speech comprehension was associated with a better perception of quality of life for all the domains of the specific questionnaire and for the self-assessment of quality of life in general. Conclusion From the users' perspective, both questionnaires showed that cochlear implant brought benefits to different aspects related to quality of life.
DOI: 10.6084/m9.figshare.6967568.v1
title: Barriers and challenges to improve interfunctional integration between Product Development and Production Planning and Control in Engineering-to-Order Environment

description: Abstract Interfunctional integration is indicated by several studies as an alternative to increased operational excellence, improving organizational performance through improved interaction and collaboration in organizational processes. The focus of this paper is to present and discuss barriers and challenges to improve interfunctional integration between Product Development (PD) and Production Planning and Control (PPC) in production systems that adopt the strategy of response to demand Engineering-to-Order (ETO). To reach that goal, we used a literature review on the topics of interest and findings obtained from the case studies of three large metal mechanical companies that design and manufacture customized-made capital goods. The following were observed as main results: barriers and challenges related to the interaction between functional areas during the process of order fulfillment, and the need for actions that seek to improve the interaction and collaboration between PD and PPC, taking into account the peculiarities of the ETO environment.
DOI: 10.6084/m9.figshare.6967565.v1
title: Quality of life and cochlear implant: results in adults with postlingual hearing loss

description: Abstract Introduction Considering the variability of results found in the clinical population using a cochlear implant, researchers in the area have been interested in the inclusion of quality of life measures to subjectively assess the benefits of the implantation. Objective To assess the quality of life of adult users of cochlear implant. Methods A cross-sectional and clinical study in a group of 26 adults of both genders, with mean duration of cochlear implant use of 6.6 years. The Nijmegen Cochlear Implantation Questionnaire and the generic World Health Organization Quality of Life questionnaire were sent electronically. Results The best assessed domain in the quality of life assessment for the cochlear implantation questionnaire was the social domain, whereas for the quality of life questionnaire it was the psychological domain. The variables, gender, time of cochlear implant use and auditory modality did not influence the results of both questionnaires. Only the variable level of education was correlated with the environment domain of the quality of life questionnaire. The variable telephone speech comprehension was associated with a better perception of quality of life for all the domains of the specific questionnaire and for the self-assessment of quality of life in general. Conclusion From the users' perspective, both questionnaires showed that cochlear implant brought benefits to different aspects related to quality of life.
DOI: 10.6084/m9.figshare.6967556
title: Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review

description: Abstract The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP.
DOI: 10.6084/m9.figshare.6967559
title: University-industry cooperation: a study of the UNISINOS - HT Micron project for developing absorptive capacity in the area of semiconductors

description: Abstract The ability of an organization to identify, assimilate and apply knowledge of the external environment is studied in the field of organizational theories under the theme of “absorptive capacity”. The mainstream literature has considered absorptive capacity as a path dependent on the organization’s trajectory, which hampers its development in a relatively short time. However, there are studies that show that depending on the kind of knowledge sought, absorptive capacity can be developed in a more specific way. Confronted with this problem, this paper investigates the development of the absorptive capacity of a Brazilian university, facing the challenge of working on a university-industry (U-I) project in the semiconductor industry. The empirical research used the case study as a methodological strategy, through in-depth interviews, taking the UNISINOS - HT Micron project as the unit of analysis. Evidence suggests that the absorptive capacity was enhanced through actions that influenced the initial knowledge base, the training of human resources, the development of the organizational structure, and the establishment of inter-organizational relationships. The results also show that the formation of absorptive capacity is not necessarily path dependent, and it can be developed, at least in part, in the context of a specific project.