cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20011955.v1
title: PRIMARY CARE APPOINTMENT SYSTEMS: CAUSES AND IMPLICATIONS OF TIMELY ARRIVALS.

description: ABSTRACT The primary goal of this study was to identify potential factors that might contribute to patient punctuality issues, while also assessing the satisfaction of a proposed intervention. In addition, we aimed to learn more about the psychosocial and behavioral implications that patients face with regards to arriving on time for their primary care visits. A mixed-method research study was used to identify and quantify potential factors that might contribute to patient punctuality issues, while also assessing the satisfaction of a proposed intervention. In addition to possible factors that contribute to punctuality, we aimed to learn more about how patients are affected when they arrive late for appointments. Through qualitative assessment, we explored the psychosocial and behavioral implications that patients face with regards to arriving on time for their primary care appointments. A total of 524 individuals out of 1050 patients (50%) responded to the paper-based survey. Of the 524 adult respondents, we excluded 103 (19.7%) participants due to the missing data on either of their historical behavior patterns, future intentions for arrival, or their definition of appointment time. We analyzed the data for the remaining 421 eligible survey participants. In addition, seven of the eight patient interviews were transcribed and analyzed in order to identify themes using the patient’s own words to better understand the psychosocial and behavioral implications patients face on arriving to their appointment on time. Three primary themes emerge in the interviews related to the perception of arriving late to appointments at the FMC. The findings of this study indicate that regardless of patients’ interpretation of appointment time, they typically arrive 10-15 minutes before the appointment time. In addition, there is a significant connection between patients’ perceptions of historically arriving late to appointments and the intent to arrive very early to their future appointments. Combined with the qualitative results, this study suggests that most patients are motivated to be on time, in some cases seeing the idea of lateness as a contradiction of their own self-identity. The behavioral causes and implications of the findings are explained using the concept of Fear Appeals and the Protection Motivation Theory (PMT).
DOI: 10.6084/m9.figshare.20484579
title: Neurologic adverse events of cancer immunotherapy

description: ABSTRACT Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neurologists, oncologists, hematologists, and other healthcare professionals who deal with cancer patients will not encounter this type of neurologic complication in their practice in the following years. This article aims to review the epidemiology, clinical manifestations, diagnosis, and management of neurological complications associated with ICI and CAR T-cell therapy.
DOI: 10.6084/m9.figshare.20484579.v1
title: Neurologic adverse events of cancer immunotherapy

description: ABSTRACT Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neurologists, oncologists, hematologists, and other healthcare professionals who deal with cancer patients will not encounter this type of neurologic complication in their practice in the following years. This article aims to review the epidemiology, clinical manifestations, diagnosis, and management of neurological complications associated with ICI and CAR T-cell therapy.
DOI: 10.6084/m9.figshare.20484584
title: Why are CGRP monoclonal antibodies not yet the first line treatment in migraine prevention?

description: ABSTRACT Migraine is a prevalent disorder and a cause of high disability, influenced by modifiable and non-modifiable risk factors. Comorbid and psychiatric illnesses are prevalent in migraine patients and should be considered when choosing preventive drugs. There have been unforeseen problems with the use of preventive treatment of migraine with oral drugs, mainly due to side-effects that cannot be tolerated and lack of efficacy, leading to high discontinuation rates. Anti-CGRP monoclonal antibodies (mAbs) have shown better tolerance profiles, based on the low dropout rates in clinical trials due to adverse events. First-line therapy is a term most expressed in some medical specialties that adopt standardized protocol treatments and may not be suitable for treating migraine. Regarding efficacy, mAbs don’t seem to perform much better than the current prophylactic oral drugs in reduction of monthly migraine days compared to placebo. Monoclonal antibodies against CGRP pathway have been prescribed recently, which raises some concern about their safety in the long term. Only side effects observation will confirm whether CGRP blockade causes susceptibility to severe side-effects, at least to specific subpopulations. CGRP may play a role in regulating uteroplacental blood flow and myometrial and uterine relaxation, as well as blood pressure control, raising the suspicion that its blockade could cause complications during pregnancy. Recent guidelines retain the recommendation of starting preventive treatment of migraine with oral drugs. Both the fact that it is new and costs are the reason why guidelines recommend the prescription of mAbs only after failure of at least two oral drugs.
DOI: 10.6084/m9.figshare.20484584.v1
title: Why are CGRP monoclonal antibodies not yet the first line treatment in migraine prevention?

description: ABSTRACT Migraine is a prevalent disorder and a cause of high disability, influenced by modifiable and non-modifiable risk factors. Comorbid and psychiatric illnesses are prevalent in migraine patients and should be considered when choosing preventive drugs. There have been unforeseen problems with the use of preventive treatment of migraine with oral drugs, mainly due to side-effects that cannot be tolerated and lack of efficacy, leading to high discontinuation rates. Anti-CGRP monoclonal antibodies (mAbs) have shown better tolerance profiles, based on the low dropout rates in clinical trials due to adverse events. First-line therapy is a term most expressed in some medical specialties that adopt standardized protocol treatments and may not be suitable for treating migraine. Regarding efficacy, mAbs don’t seem to perform much better than the current prophylactic oral drugs in reduction of monthly migraine days compared to placebo. Monoclonal antibodies against CGRP pathway have been prescribed recently, which raises some concern about their safety in the long term. Only side effects observation will confirm whether CGRP blockade causes susceptibility to severe side-effects, at least to specific subpopulations. CGRP may play a role in regulating uteroplacental blood flow and myometrial and uterine relaxation, as well as blood pressure control, raising the suspicion that its blockade could cause complications during pregnancy. Recent guidelines retain the recommendation of starting preventive treatment of migraine with oral drugs. Both the fact that it is new and costs are the reason why guidelines recommend the prescription of mAbs only after failure of at least two oral drugs.
DOI: 10.6084/m9.figshare.20484582
title: Artificial intelligence and Big Data in neurology

description: ABSTRACT Recent advances in technology have allowed us access to a multitude of datasets pertaining to various dimensions in neurology. Together with the enormous opportunities, we also face challenges related to data quality, ethics and intrinsic difficulties related to the application of data science in healthcare. In this article we will describe the main advances in the field of artificial intelligence and Big Data applied to neurology with a focus on neurosciences based on medical images. Real-World Data (RWD) and analytics related to large volumes of information will be described as well as some of the most relevant scientific initiatives at the time of this writing.
DOI: 10.6084/m9.figshare.20484590
title: Cerebrospinal fluid analysis: current diagnostic methods in central nervous system infectious diseases

description: ABSTRACT Cerebrospinal fluid (CSF) analysis is an important diagnostic tool for many conditions affecting the central nervous system (CNS), especially CNS infectious diseases. Despite its low specificity, CSF white blood cell counts, CSF protein levels, CSF serum glucose ratio and CSF lactate measurement are useful in differentiating infections caused by distinct groups of pathogens. CSF direct examination and cultures can identify causative organisms and antibiotic sensitivities as well. Adjunctive tests such as latex agglutination, different immunological assays and molecular reactions have great specificities and increasing sensitivities. In this article, some recent diagnostic methods applied to CSF analysis for frequent CNS infections are presented.
DOI: 10.6084/m9.figshare.20484590.v1
title: Cerebrospinal fluid analysis: current diagnostic methods in central nervous system infectious diseases

description: ABSTRACT Cerebrospinal fluid (CSF) analysis is an important diagnostic tool for many conditions affecting the central nervous system (CNS), especially CNS infectious diseases. Despite its low specificity, CSF white blood cell counts, CSF protein levels, CSF serum glucose ratio and CSF lactate measurement are useful in differentiating infections caused by distinct groups of pathogens. CSF direct examination and cultures can identify causative organisms and antibiotic sensitivities as well. Adjunctive tests such as latex agglutination, different immunological assays and molecular reactions have great specificities and increasing sensitivities. In this article, some recent diagnostic methods applied to CSF analysis for frequent CNS infections are presented.
DOI: 10.6084/m9.figshare.20522897
title: An outbreak of systemic intoxication with irritant contact dermatitis due cypermethrin in dairy cows - case report

description: ABSTRACT Pyrethroids are ectoparasiticides safe for mammals and widely used in farm animals. An outbreak of systemic intoxication with irritant contact dermatitis resulting from the use of cypermethrin pour on in dairy cows is reported in the state of Pernambuco. Eight adult animals were affected, three died on the property and five were referred to the Clínica de Bovinos, Universidade Federal Rural de Pernambuco, Campus Garanhuns. These received 100 mL of pour on Cypermethrin (Ectonil ®, Cipermetrina, Labgard, Brasil). Apathy, hyperexcitability, muscle tremors, sialorrhea, bradycardia and crusted lesions were observed on the dorsum of the neck, scapula, ears and ulcerations in the oral and vaginal mucosa. There was hyperfibrinogenemia and leukocytosis due to neutrophilia with a regenerative left shift. Histopathology showed areas of erosion and ulceration of the epidermis and perivascular lymphohistiocytic and neutrophilic infiltrate in the superficial dermis. Supportive treatment was done with improvement of systemic signs and skin lesions, however, in one animal (with 19 days hospitalized), there was no complete regression of neurological alterations of bradycardia and muscle tremors, even so, it was possible to return to productive activity. High doses of pour on cypermethrin may cause systemic intoxication in cattle and result in bradycardia, hyperexcitability, muscle tremors and sialorrhea with irritant contact dermatitis, and death in severe cases.
DOI: 10.6084/m9.figshare.20522897.v1
title: An outbreak of systemic intoxication with irritant contact dermatitis due cypermethrin in dairy cows - case report

description: ABSTRACT Pyrethroids are ectoparasiticides safe for mammals and widely used in farm animals. An outbreak of systemic intoxication with irritant contact dermatitis resulting from the use of cypermethrin pour on in dairy cows is reported in the state of Pernambuco. Eight adult animals were affected, three died on the property and five were referred to the Clínica de Bovinos, Universidade Federal Rural de Pernambuco, Campus Garanhuns. These received 100 mL of pour on Cypermethrin (Ectonil ®, Cipermetrina, Labgard, Brasil). Apathy, hyperexcitability, muscle tremors, sialorrhea, bradycardia and crusted lesions were observed on the dorsum of the neck, scapula, ears and ulcerations in the oral and vaginal mucosa. There was hyperfibrinogenemia and leukocytosis due to neutrophilia with a regenerative left shift. Histopathology showed areas of erosion and ulceration of the epidermis and perivascular lymphohistiocytic and neutrophilic infiltrate in the superficial dermis. Supportive treatment was done with improvement of systemic signs and skin lesions, however, in one animal (with 19 days hospitalized), there was no complete regression of neurological alterations of bradycardia and muscle tremors, even so, it was possible to return to productive activity. High doses of pour on cypermethrin may cause systemic intoxication in cattle and result in bradycardia, hyperexcitability, muscle tremors and sialorrhea with irritant contact dermatitis, and death in severe cases.
DOI: 10.6084/m9.figshare.20484597
title: Cannabidiol and epilepsy in Brazil: a current review

description: ABSTRACT Background: Cannabidiol (CBD) has become a promising therapeutic option in the treatment of epilepsy. Recent studies provide robust evidence that CBD is effective and safe. Limitations in current knowledge and regulatory issues still limit CBD use. CBD use regarding epilepsy types still lacks clear guidelines. Objective: To critically review the main current pharmacological features and clinical issues regarding CBD use in epilepsy, to provide current regulatory background regarding CBD use in Brazil, and to suggest a practical CBD therapeutic guide in Brazil. Methods: Non-systematic literature review (up to February 2022) of current concepts of CBD and epilepsy, including the authors’ personal experience. Results: Five pivotal trials have led to CBD approval as an adjunctive treatment for Dravet and Lennox-Gastaut syndromes, and for the tuberous sclerosis complex. Efficacy of CBD in other drug-resistant epilepsies remains not completely understood. CBD adverse event profile and drug interactions are better understood. CBD is well tolerated. In Brazil, CBD is not classified as a medication, but as a product subject to a distinct regulatory legislation. CBD is still not offered by the National Brazilian health system, but can be purchased in authorized pharmacies or imported under prescription and signed informed consent. Conclusion: CBD is a recognized novel treatment for epilepsy. Future well-designed studies and public health strategies are needed to offer widespread access to CBD, and to improve the quality of life of people living with epilepsy in Brazil.
DOI: 10.6084/m9.figshare.20484597.v1
title: Cannabidiol and epilepsy in Brazil: a current review

description: ABSTRACT Background: Cannabidiol (CBD) has become a promising therapeutic option in the treatment of epilepsy. Recent studies provide robust evidence that CBD is effective and safe. Limitations in current knowledge and regulatory issues still limit CBD use. CBD use regarding epilepsy types still lacks clear guidelines. Objective: To critically review the main current pharmacological features and clinical issues regarding CBD use in epilepsy, to provide current regulatory background regarding CBD use in Brazil, and to suggest a practical CBD therapeutic guide in Brazil. Methods: Non-systematic literature review (up to February 2022) of current concepts of CBD and epilepsy, including the authors’ personal experience. Results: Five pivotal trials have led to CBD approval as an adjunctive treatment for Dravet and Lennox-Gastaut syndromes, and for the tuberous sclerosis complex. Efficacy of CBD in other drug-resistant epilepsies remains not completely understood. CBD adverse event profile and drug interactions are better understood. CBD is well tolerated. In Brazil, CBD is not classified as a medication, but as a product subject to a distinct regulatory legislation. CBD is still not offered by the National Brazilian health system, but can be purchased in authorized pharmacies or imported under prescription and signed informed consent. Conclusion: CBD is a recognized novel treatment for epilepsy. Future well-designed studies and public health strategies are needed to offer widespread access to CBD, and to improve the quality of life of people living with epilepsy in Brazil.
DOI: 10.6084/m9.figshare.20522900
title: Historical experience of industrial policy in Brazil

description: ABSTRACT This paper studies the practice of industrial policy and the corresponding effort of institution building in Brazil from the 1930s to the 1970s. The argument is that, although that practice and the respective institutional organization succeeded in the structuring of Brazilian industry into a process of convergence towards the international industrial structure and technological development patterns up to the 1970s, they showed themselves not functional in catching up with the structural changes and the new technologies of the 1980s. The paper concludes by pointing that both the established practice of industrial policy and the related institutional organization led to a normative and institutional lock in which, together with the political inertia, hindered the necessary changes at the beginning of the 1980s.
DOI: 10.6084/m9.figshare.20522900.v1
title: Historical experience of industrial policy in Brazil

description: ABSTRACT This paper studies the practice of industrial policy and the corresponding effort of institution building in Brazil from the 1930s to the 1970s. The argument is that, although that practice and the respective institutional organization succeeded in the structuring of Brazilian industry into a process of convergence towards the international industrial structure and technological development patterns up to the 1970s, they showed themselves not functional in catching up with the structural changes and the new technologies of the 1980s. The paper concludes by pointing that both the established practice of industrial policy and the related institutional organization led to a normative and institutional lock in which, together with the political inertia, hindered the necessary changes at the beginning of the 1980s.
DOI: 10.6084/m9.figshare.20522903
title: Morphological study of the pineal gland of Alouatta belzebul

description: ABSTRACT The pineal is a neuroendocrine gland responsible for the synthesis and release of melatonin. It is present in the brain of vertebrates, but its morphology and location vary considerably among species. For the species Alouatta belzebul, although some anatomical aspects of the nervous system have been described, there is no information on the morphology and histological composition of this gland. Thus, the present study aimed to describe the morphological, morphometric, and histological aspects of the pineal of Alouatta belzebul. Seven adult specimens were dissected from which the location of the gland in relation to the surrounding brain structures was described, and its length and width were measured. Histological slides were then prepared and stained using hematoxylin-eosin and PAS techniques. It was observed that the pineal of Alouatta belzebul is located superior and cranial to the cerebellum, superior to the superior colliculi and below the splenium of the corpus callosum and was classified as sub-callosal. It had an average length of 2.6mm and an average width of 1.14mm. Histologically the gland is composed of irregular strands of pinealocytes and gliocytes. The pinealocytes showed pigments similar to melanin.
DOI: 10.6084/m9.figshare.20522903.v1
title: Morphological study of the pineal gland of Alouatta belzebul

description: ABSTRACT The pineal is a neuroendocrine gland responsible for the synthesis and release of melatonin. It is present in the brain of vertebrates, but its morphology and location vary considerably among species. For the species Alouatta belzebul, although some anatomical aspects of the nervous system have been described, there is no information on the morphology and histological composition of this gland. Thus, the present study aimed to describe the morphological, morphometric, and histological aspects of the pineal of Alouatta belzebul. Seven adult specimens were dissected from which the location of the gland in relation to the surrounding brain structures was described, and its length and width were measured. Histological slides were then prepared and stained using hematoxylin-eosin and PAS techniques. It was observed that the pineal of Alouatta belzebul is located superior and cranial to the cerebellum, superior to the superior colliculi and below the splenium of the corpus callosum and was classified as sub-callosal. It had an average length of 2.6mm and an average width of 1.14mm. Histologically the gland is composed of irregular strands of pinealocytes and gliocytes. The pinealocytes showed pigments similar to melanin.
DOI: 10.6084/m9.figshare.20522904
title: MULTIMODAL ANALYSIS: FUNDAMENTAL NOTIONS AND PROCEDURES

description: ABSTRACT Drawing on Systemic Functional Theory and the decompositional model proposed by Bateman, Wildfeuer and Hiippala (2017), this paper outlines notions and procedures we consider fundamental for the analysis of multimodal texts, particularly digital ones, by providing a theoretical and methodological model that enables a greater commitment to a clear and replicable organization of the analytical procedure. We introduce the fundamental systemic functional concepts of realization and instantiation and their implications for the study of multimodality; next, we present the notion of ‘canvas’ and the multidimensional classification of semiotic materialities; then, we make explicit the basic steps for the substantiation of the analysis of multimodal texts; and, finally, we exemplify the model with a cursory analysis of the canvas composition of Facebook posts.
DOI: 10.6084/m9.figshare.20522904.v1
title: MULTIMODAL ANALYSIS: FUNDAMENTAL NOTIONS AND PROCEDURES

description: ABSTRACT Drawing on Systemic Functional Theory and the decompositional model proposed by Bateman, Wildfeuer and Hiippala (2017), this paper outlines notions and procedures we consider fundamental for the analysis of multimodal texts, particularly digital ones, by providing a theoretical and methodological model that enables a greater commitment to a clear and replicable organization of the analytical procedure. We introduce the fundamental systemic functional concepts of realization and instantiation and their implications for the study of multimodality; next, we present the notion of ‘canvas’ and the multidimensional classification of semiotic materialities; then, we make explicit the basic steps for the substantiation of the analysis of multimodal texts; and, finally, we exemplify the model with a cursory analysis of the canvas composition of Facebook posts.