cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21942/uva.10007840.v1
title: The Amsterdam Ultra-high field adult lifespan database (AHEAD): A freely available multimodal 7 Tesla submillimeter magnetic resonance imaging database

description: The <b>A</b>msterdam Ultra-<b>h</b>igh fi<b>e</b>ld <b>a</b>dult lifespan<b> d</b>atabase (AHEAD) consists of 105 7 Tesla (T) whole-brain structural MRI scans tailored specifically to imaging of the human subcortex, including both male and female participants and covering the entire adult life span (19-80 yrs). Data was acquired at a submillimeter resolution using a single multi-echo magnetization-prepared rapid gradient echo (MP2RAGEME) sequence, resulting in complete anatomical alignment of quantitative, R<sub>1</sub>-maps, R<sub>2</sub><sup>*</sup>-maps, T<sub>1</sub>-maps, T<sub>1</sub>-weighted images, T<sub>2</sub><sup>*</sup>-maps, and quantitative susceptibility mapping (QSM). Probability maps were created for five individual basal ganglia structures.
DOI: 10.14284/567
title: Benthic invertebrate sampling over gradients of commercial trawling intensity and oxygen depletion in the Southern Baltic Sea

description: Benthic sampling with box core and dredge in 19 sampling locations in the Southern Baltic Sea in Polish waters.
description: Sampling was carried from on board the research vessel RV Oceanograf between 3 and 7 September 2018. Five replicate box core and two replicate dredge samples were collected from each station in the Southern Baltic Sea in Polish waters.
DOI: 10.5281/zenodo.6609750
title: Evaluation Set - Contributions Similarity in the Open Research Knowledge Graph

description: This evaluation set has been created for evaluating a content-based recommender system in the context of the Open Research Knowledge Graph (ORKG). The recommender system accepts structured ORKG contribution as input and recommends existing contributions in the ORKG semantically relevant to the given one. The evaluation set is manually annotated based on the featured comparisons in the ORKG. In the course of this, it has been distinguished between homogeneous (those who are dissimilar in 2-3 properties) and heterogeneous (otherwise) instances. Multiple annotations have been obtained for the former and exactly one for the latter. It has been also distinguished between "with_response" and "without_response" instances (50 instances for each). The former are those contributions for them the initial version of the contributions similarity service has found similarities and the latter are the opposite case. This evaluation set has been created and applied on a modified version of the contributions similarity service in the context of this master's thesis. The modified version of the service has simplified the document representation of contributions that are stored in an ElasticSearch index by omitting redundant terms. The evaluation set has the following schema: <pre><code class="language-json">{ "with_response": [ { "contribution_id": "some_id", "comparison_id": "some_id", "comparison_label": "some_label", "contribution_label": "some_label", "paper": "some_id", "research_field": "some_id", "research_problems": [ "some_id" ], "annotations": [ "some_id of a similar contribution", ... ] }, ... ], "without_response": [ ... ] }</code></pre>
DOI: 10.5281/zenodo.6609749
title: Evaluation Set - Contributions Similarity in the Open Research Knowledge Graph

description: This evaluation set has been created for evaluating a content-based recommender system in the context of the Open Research Knowledge Graph (ORKG). The recommender system accepts structured ORKG contribution as input and recommends existing contributions in the ORKG semantically relevant to the given one. The evaluation set is manually annotated based on the featured comparisons in the ORKG. In the course of this, it has been distinguished between homogeneous (those who are dissimilar in 2-3 properties) and heterogeneous (otherwise) instances. Multiple annotations have been obtained for the former and exactly one for the latter. It has been also distinguished between "with_response" and "without_response" instances (50 instances for each). The former are those contributions for them the initial version of the contributions similarity service has found similarities and the latter are the opposite case. This evaluation set has been created and applied on a modified version of the contributions similarity service in the context of this master's thesis. The modified version of the service has simplified the document representation of contributions that are stored in an ElasticSearch index by omitting redundant terms. The evaluation set has the following schema: <pre><code class="language-json">{ "with_response": [ { "contribution_id": "some_id", "comparison_id": "some_id", "comparison_label": "some_label", "contribution_label": "some_label", "paper": "some_id", "research_field": "some_id", "research_problems": [ "some_id" ], "annotations": [ "some_id of a similar contribution", ... ] }, ... ], "without_response": [ ... ] }</code></pre>
DOI: 10.6084/m9.figshare.19977671
title: Use of insulin-like growth factor in the healing of open wounds in diabetic and non-diabetic rats

description: PURPOSE: To analyze the effects of application of 1% and 3% insulin-like growth factor I (IGF-1) cream on the process of wound healing in induced skin lesions in diabetic and non-diabetic rats and evaluate its effect on expression of myofibroblasts.METHODS: Ninety-six Wistar adult male rats were divided into six groups, with 16 rats in each group, as follows: group 1: non-diabetic, untreated; group 2: non-diabetic, treated with 1% IGF-1 cream; group 3: non-diabetic, treated with 3% IGF-1 cream; group 4: diabetic, untreated; group 5: diabetic, treated with 1% IGF-1 cream; and group 6: diabetic, treated with 3% IGF-1 cream. In groups 4, 5, and 6, diabetes was induced by intravenous injection of alloxan. After diabetes had been induced, animals were mantained for 3 months. The experimental procedure consisted of the creation of a circular incision of 0.9 mm in diameter using a metal punch. Following this, wounds were treated daily according to the assigned treatment regimen. Groups 2 and 5 were treated with 1% IGF-1 cream, groups 3 and 6 with 3% IGF-1 cream, and groups 1 and 4 and the untreated groups with 0.9% saline solution. From each group, samples from 4 rats were taken at three, seven, 14, and 21 days after the injury. Samples were fixed in 10% formalin to prepare slides for histological analysis. Slides stained with hematoxylin-eosin (H&E) and Masson were observed vascular proliferation, mononuclear cells, polymorphonuclear cells, fibroblast proliferation, re-epithelialization, and collagen fibers. This study analyzed the expression of α-smooth muscle actin using specific antibodies to correlate the temporal expression of α-smooth muscle-specific actin (α-SM actin), a molecular marker for myofibroblast transformation.RESULTS:Macroscopic observation of wounds showed a more rapid re-epithelialization of wounds treated with IGF. Regarding acute inflammatory reactions, the results of the analysis of vascular proliferation and polymorphonuclear and mononuclear cells showed no statistically significant differences in any of the periods studied (according to the results of a Mann-Whitney test). The initial immunohistochemical analysis of tissue samples conducted to compare the expression of α-smooth muscle actin between groups showed a relevant response in the expression of myofibroblasts. Data were analyzed using ANOVA and were found to be statistically significant.CONCLUSION: The topical application of 1% and 3% IGF-1 creams increases the expression of myofibroblasts in the process of wound healing in rats.
DOI: 10.6084/m9.figshare.19977671.v1
title: Use of insulin-like growth factor in the healing of open wounds in diabetic and non-diabetic rats

description: PURPOSE: To analyze the effects of application of 1% and 3% insulin-like growth factor I (IGF-1) cream on the process of wound healing in induced skin lesions in diabetic and non-diabetic rats and evaluate its effect on expression of myofibroblasts.METHODS: Ninety-six Wistar adult male rats were divided into six groups, with 16 rats in each group, as follows: group 1: non-diabetic, untreated; group 2: non-diabetic, treated with 1% IGF-1 cream; group 3: non-diabetic, treated with 3% IGF-1 cream; group 4: diabetic, untreated; group 5: diabetic, treated with 1% IGF-1 cream; and group 6: diabetic, treated with 3% IGF-1 cream. In groups 4, 5, and 6, diabetes was induced by intravenous injection of alloxan. After diabetes had been induced, animals were mantained for 3 months. The experimental procedure consisted of the creation of a circular incision of 0.9 mm in diameter using a metal punch. Following this, wounds were treated daily according to the assigned treatment regimen. Groups 2 and 5 were treated with 1% IGF-1 cream, groups 3 and 6 with 3% IGF-1 cream, and groups 1 and 4 and the untreated groups with 0.9% saline solution. From each group, samples from 4 rats were taken at three, seven, 14, and 21 days after the injury. Samples were fixed in 10% formalin to prepare slides for histological analysis. Slides stained with hematoxylin-eosin (H&E) and Masson were observed vascular proliferation, mononuclear cells, polymorphonuclear cells, fibroblast proliferation, re-epithelialization, and collagen fibers. This study analyzed the expression of α-smooth muscle actin using specific antibodies to correlate the temporal expression of α-smooth muscle-specific actin (α-SM actin), a molecular marker for myofibroblast transformation.RESULTS:Macroscopic observation of wounds showed a more rapid re-epithelialization of wounds treated with IGF. Regarding acute inflammatory reactions, the results of the analysis of vascular proliferation and polymorphonuclear and mononuclear cells showed no statistically significant differences in any of the periods studied (according to the results of a Mann-Whitney test). The initial immunohistochemical analysis of tissue samples conducted to compare the expression of α-smooth muscle actin between groups showed a relevant response in the expression of myofibroblasts. Data were analyzed using ANOVA and were found to be statistically significant.CONCLUSION: The topical application of 1% and 3% IGF-1 creams increases the expression of myofibroblasts in the process of wound healing in rats.
DOI: 10.6084/m9.figshare.19977673
title: C-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage1

description: PURPOSE: To evaluate the relationship between C reactive protein levels and clinical and radiological parameters with delayed ischemic neurological deficits and outcome after aneurysmal subarachnoid hemorrhage.METHODS: One hundred adult patients with aneurismal SAH were prospectively evaluated. Besides the baseline characteristics, daily C-reactive protein levels were prospectively measured until day 10 after subarachnoid hemorrhage. The primary end point was outcome assessed by Glasgow Outcome Scale, the secondary was the occurrence of delayed ischemic neurological deficits (DINDs).RESULTS:A progressive increase in the CRP levels from the admission to 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS on discharge and CRP levels.CONCLUSIONS:Higher C-reactive protein serum levels are associated with worse clinical outcome and the occurrence of delayed ischemic neurological deficits. Because C-reactive protein levels were significantly elevated in the early phase, they might be a useful parameter to monitor.
DOI: 10.6084/m9.figshare.19977673.v1
title: C-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage1

description: PURPOSE: To evaluate the relationship between C reactive protein levels and clinical and radiological parameters with delayed ischemic neurological deficits and outcome after aneurysmal subarachnoid hemorrhage.METHODS: One hundred adult patients with aneurismal SAH were prospectively evaluated. Besides the baseline characteristics, daily C-reactive protein levels were prospectively measured until day 10 after subarachnoid hemorrhage. The primary end point was outcome assessed by Glasgow Outcome Scale, the secondary was the occurrence of delayed ischemic neurological deficits (DINDs).RESULTS:A progressive increase in the CRP levels from the admission to 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS on discharge and CRP levels.CONCLUSIONS:Higher C-reactive protein serum levels are associated with worse clinical outcome and the occurrence of delayed ischemic neurological deficits. Because C-reactive protein levels were significantly elevated in the early phase, they might be a useful parameter to monitor.
DOI: 10.6084/m9.figshare.19977674.v1
title: Effect of vitamin K1 supplementation on left colon healing in rats with extrahepatic biliary obstruction

description: PURPOSE:To evaluate the effects of vitamin K1 on wound healing in the left colon of rats with experimental biliary obstruction.METHODS: Sixteen male rats, divided into four groups of four animals each (L, M, LK, and MK), underwent colostomy followed by bowel suture in the left colon. Seven days before, animals in the L and LK groups had undergone common bile duct ligation. The animals in groups MK and LK received vitamin K1 supplementation. On day 7 after bowel suture, repeat laparotomy was performed for evaluation of colonic healing by burst pressure measurement and collection of samples for histopathological analysis. Changes in body weight were evaluated in the four groups.RESULTS:Weight loss was lower in animals supplemented with vitamin K. No significant differences were observed in burst pressure among the four groups (p&gt;0.05). Histological analysis showed more hemorrhage and congestion in the biliary obstruction groups. Supplemented animals exhibited increased collagen formation and less edema and abscess formation.CONCLUSION:Vitamin K supplementation attenuated weight loss and improved colonic wound healing in rats.
DOI: 10.6084/m9.figshare.19977674
title: Effect of vitamin K1 supplementation on left colon healing in rats with extrahepatic biliary obstruction

description: PURPOSE:To evaluate the effects of vitamin K1 on wound healing in the left colon of rats with experimental biliary obstruction.METHODS: Sixteen male rats, divided into four groups of four animals each (L, M, LK, and MK), underwent colostomy followed by bowel suture in the left colon. Seven days before, animals in the L and LK groups had undergone common bile duct ligation. The animals in groups MK and LK received vitamin K1 supplementation. On day 7 after bowel suture, repeat laparotomy was performed for evaluation of colonic healing by burst pressure measurement and collection of samples for histopathological analysis. Changes in body weight were evaluated in the four groups.RESULTS:Weight loss was lower in animals supplemented with vitamin K. No significant differences were observed in burst pressure among the four groups (p&gt;0.05). Histological analysis showed more hemorrhage and congestion in the biliary obstruction groups. Supplemented animals exhibited increased collagen formation and less edema and abscess formation.CONCLUSION:Vitamin K supplementation attenuated weight loss and improved colonic wound healing in rats.
DOI: 10.6084/m9.figshare.19977676
title: Copaiba oil effect under different pathways in mice subjected to sepsis

description: PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture.METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized.RESULTS:All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p&lt;0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p&gt;0.05)CONCLUSION:Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
DOI: 10.6084/m9.figshare.19977676.v1
title: Copaiba oil effect under different pathways in mice subjected to sepsis

description: PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture.METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized.RESULTS:All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p&lt;0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p&gt;0.05)CONCLUSION:Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
DOI: 10.6084/m9.figshare.19977677
title: Face transplantation in rats. Reproducibility of the experimental model in Brazil

description: PURPOSE:To investigate the reproducibility of the experimental model of face allotransplantation in rats in Brazil.METHODS: Eighteen rats were operated, nine-nine donors recipients. Animals underwent transplantation of the left hemiface, with periorbital and scalp. Transplants were made from donor Wistar rats to recipients Lewis rats. Flaps were based on the common carotid artery and the external jugular vein of the donor animal and the anastomosis in the recipient area was performed in common carotid artery (end-to-side) and in external jugular vein (end-to-end).RESULTS:Of the nine recipient animals operated, six survived and three progressed to death in the first days after surgery (survival rate = 67%). The mean time of the procedure was 252 minutes and the mean time of flap ischemia was 95 minutes. The five surviving animals were sacrificed at 14 days, in good general condition and without signs of tissue rejection.CONCLUSIONS:The experimental model of face allotransplantation in rats is reproducible in our midst. Duration of surgery, time of flap ischemia, animal survival rate and complications observed were similar to those described in the literature.
DOI: 10.6084/m9.figshare.19977677.v1
title: Face transplantation in rats. Reproducibility of the experimental model in Brazil

description: PURPOSE:To investigate the reproducibility of the experimental model of face allotransplantation in rats in Brazil.METHODS: Eighteen rats were operated, nine-nine donors recipients. Animals underwent transplantation of the left hemiface, with periorbital and scalp. Transplants were made from donor Wistar rats to recipients Lewis rats. Flaps were based on the common carotid artery and the external jugular vein of the donor animal and the anastomosis in the recipient area was performed in common carotid artery (end-to-side) and in external jugular vein (end-to-end).RESULTS:Of the nine recipient animals operated, six survived and three progressed to death in the first days after surgery (survival rate = 67%). The mean time of the procedure was 252 minutes and the mean time of flap ischemia was 95 minutes. The five surviving animals were sacrificed at 14 days, in good general condition and without signs of tissue rejection.CONCLUSIONS:The experimental model of face allotransplantation in rats is reproducible in our midst. Duration of surgery, time of flap ischemia, animal survival rate and complications observed were similar to those described in the literature.
DOI: 10.6084/m9.figshare.19977698.v1
title: Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats

description: PURPOSE: To analyze Pten and Smad4 gene expression in the urogenital system of Wistar rats in differents ages. METHODS: Pten and Smad4 mRNA expression was assessed in the bladder, ventral prostate, testis, ovaries, and uterus by real-time PCR. Statistical analysis using the ANOVA (p&lt;0.05). RESULTS: Pten levels showed a progressive age-dependent increase in the bladder (male and female) and prostate and were elevated in the ovaries of the middle-aged. In the uterus, no statistically significant differences were observed; in the testis, increased and decreased levels were seen in young adult and middle-aged rats, respectively. Smad4 expression was downregulated in the ovaries of the pubertal group but increased in the middle age group. In the uterus, Smad4 expression in the oldest group was higher than the others groups. In the testis, Smad4 expression steadily declined with age; in the prostate, it was higher in middle-aged rats than in younger rats. A similar trend was observed in the bladder of male and female middle-aged rats, compared with the pubertal group. CONCLUSION: The changes in phosphatase tensin homologue and Smad4 mRNA expression in Wistar rats appear to be associated with hormonal modifications in puberty and may be related to early follicular and testicular development.