cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2016.707
title: Development of elastic liposomes of caffeine for the treatment of cellulite

description: In this study, caffeine elastic liposomes were developed for cellulite treatment by using the combination of surfactant and ethanol. The elastic liposomes studied consisted of phosphatidylcholine as the structural lipid, Span® 80 or Tween® 80 of the same molar ratio (5-10% w/w and 15-25% w/w of total lipid, respectively) as the edge activator and various concentrations of ethanol (5-25% v/v). The effects of type and amount of surfactants and concentration of ethanol on physical properties i.e., vesicle formation, size and size distribution and elasticity of blank liposomes were investigated. The blank liposome formulations with highest elasticity of each surfactant were selected to prepare the caffeine-containing elastic liposomes. These elastic liposomes were characterized for physical properties including entrapment efficiency and physical stability. The skin delivery of caffeine from the chosen elastic liposome formulations were carried out in vitro with modified Franz diffusion cells under the non-occlusive condition using newborn pig skin as the model membrane. The results showed that the complete vesicle formation was observed at low ethanol concentrations (5-15% v/v). The vesicle size of liposomes composed of Span® 80 and Tween® 80 was in the range of 5.84-8.08 µm and 3.73-5.27 µm, respectively. The combination of surfactant and ethanol showed significant effects on physical properties of elastic liposomes. The elasticity of liposomes containing Span® 80 and Tween® 80 was in the range of 27.07-79.86% and 8.44-15.74%, respectively. The formulations with highest elasticity, S7.5_5 with Span® 80 7.5% w/w and ethanol 5% v/v and T20_5 with Tween® 80 20% w/w and ethanol 5% v/v, were chosen to load caffeine. In general, physical properties of caffeine elastic liposomes were similar to the corresponding blank liposomes. However, caffeine loading decreased the elasticity of caffeine-entrapped elastic liposome formulations by approximately 20-30% compared to that of the blank elastic liposomes. The elasticity values of the caffeine-loaded elastic liposome formulations S7.5_5 and T20_5 were 53.46±8.63% and 11.93±0.46%, respectively. The entrapment efficiency values of S7.5_5 was lower than that of T20_5 (35.05±0.60 and 41.31±3.32% w/w, respectively). Skin permeation from S7.5_5 and T20_5 were significantly higher than that from the hydro-alcoholic solution used as the aqueous phase of these elastic liposomes. However, despite the profound difference in elasticity between the 2 formulations, no significantly differences were seen in most permeation parameters studied. The only significant difference detected was the enhancement factor of caffeine amount in the skin, the mean of which was almost doubled for the S7.5_5 formulation when compared to the T20_5 formulation.
DOI: 10.14457/cu.the.2018.466
title: Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phaseof sepsis

description: Background: Piperacillin/Tazobactam is frequently used for empirical treatment in patients with sepsis. Pathophysiological changes during the early phase of sepsis have significant effects on pharmacokinetic/pharmacodynamic (PK/PD) behaviors. This study aimed to characterize the population PKs of piperacillin and investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) of various dosage regimens in critically ill patients during the early phase of sepsis. Methods: Forty-eight patients treated with piperacillin/tazobactam were recruited. Five blood samples were drawn before and during 0-0.5, 0.5-2, 2-4 and 4-6 or 8 hours after administration. Free piperacillin concentrations were determined using HPLC. Population PKs was analyzed using NONMEM®. The PTA of 90%fT&gt;MIC target and CFR were determined by Monte Carlo simulation. Results: The two compartment model best described the data. Piperacillin clearance (CL), central volume of distribution (V1) and peripheral volume of distribution were 5.37 L/h, 9.35 L, and 7.77 L, respectively. Creatinine clearance (CLCr) and mean arterial pressure had a significant effect on CL while adjusted body weight had a significant impact on V1. The standard regimen, 4-g of piperacillin infused over 0.5 hours every 6 hours, achieved the target for susceptible organisms with MIC ≤16 mg/L in patients with CLCr 10 to 40 ml/min, but not with CLCr 40-120 ml/min. In such patients, prolonged infusion is required. Most regimens provided CFR 90% for the E. coli infection while there was no dosage regimen achieved a CFR of 90% for the P. aeruginosa infection. Conclusions: Due to high CL and V1, subtherapeutic concentrations can occur during the early phase of sepsis in critically ill patients with normal renal function. Our proposed regimen for the patients with CLCr 40-120 ml/min was an extended 4-hour infusion of 4-g of piperacillin every 6 hours.
DOI: 10.14457/cu.the.2017.940
title: Preparation and stabilization of x-ray amorphous solid state structure of salbutamol sulfate adsorbed on mesoporous silica

description: The main objective of this study was to focus on the preparation of X-ray amorphous salbutamol sulfate (SS) with mesoporous silica (S244 silica) carrier by using incipient wetness impregnation approach and further investigated on the utilization of poly (vinylpyrrolidone) (PVP) K12 for the stabilization of amorphous produced. Initially, SS was prepared in solution state and later loaded on S244 silica. The output product showed the non-ordered arrangement of SS with the longer interconversion time to crystalline when comparing with ground amorphous SS. It should be explained that SS was located on the silica surface randomly with no molecular packing according to hydrogen-bonding and weak attractive forces. The molecular mobility was then slower than non-ordered amorphous ground SS. Therefore, the more stable X-ray amorphous SS was gained. PVP K12, short chain vinyl polymer, was utilized as a model polymer for amorphous stabilization. It provided an adverse effect for X-ray amorphous SS adsorbed on S244 silica. The PVP K12 concentration 5 to 30% w/w of drug obviously accelerated the crystalline form formation on the S244 silica surface. Meanwhile, the lower concentration 0.1-1% w/w showed comparable result on the amorphous interconversion rate to that of the control (product not contain PVP K12). This finding contradicted to several previous reported that showed the positive effect of higher concentration of polymer on the retardation of amorphous interconversion. It might be due to the degree of competitiveness on the surface adsorption of silica surface and PVP K12 or SS molecule.
DOI: 10.14457/cu.the.2016.708
title: Pharmacokinetic study of puerarin in rats

description: Pueraria candollei var. mirifica is a medicinal plant which has been promoted as a “Champion Product” by the Government of Thailand. Puerarin, the major bioactive component of this plant, has been an interest of pharmacodynamic activity against aging diseases, but there is little pharmacokinetic information to support further study of this activity. Therefore, the aim of this study was to determine the pharmacokinetics of puerarin, including absorption, distribution, metabolism and elimination, in female rats. Moreover, this is the first study to examine the tissue distribution of puerarin in the hippocampus, femur and tibia, and mammary gland based on recently the pharmacodynamic effects reported for neurodegenerative disease, osteoporosis, and breast cancer, respectively. Adult female rats were administered puerarin at 1 mg/kg intravenously or 5 and 10 mg/kg orally. Blood, tissue, urine and feces were collected and analysed by liquid chromatography-tandem mass spectrometry. Puerarin reached a maximum concentration in blood within 1 h after oral dosing, and had an absolute oral bioavailability of approximately 7%. Puerarin was widely distributed in several tissues, including the hippocampus, heart, lung, stomach, liver, mammary gland, kidney, spleen, femur, and tibia. Approximately 50% of the intravenous dose was excreted as glucuronide metabolites via the urinary route. These results are useful for the development of puerarin and Pueraria candollei var. mirifica as phytopharmaceutical products for the prevention and treatment of aging diseases.
DOI: 10.14457/cu.the.2016.709
title: Formulation development of celecoxib-cyclodextrin suspensions for ophthalmic delivery

description: Celecoxib (CCB), a nonsteroidal anti-inflammatory drug (NSAID), could be beneficial in the treatment of age-related macular degeneration (AMD) and diabetic retinopathy (DR) through the inhibition of COX-2 enzyme. Currently, the several methods can deliver drugs to the back of the eye. i.e., oral, intravitreal injection, subconjunctival injection and topical. Among routes of administration, topical eye drop is non-invasive method and local effects. However, due to low aqueous solubility of CCB, it hampers ocular bioavailability. Thus, the aim of this study was to develop topical eye drop suspensions containing cyclodextrin (CD) and polymer delivering to the posterior segment of the eye. CDs, the solubilizer, i.e., alpha-CD, beta-CD, gamma-CD, HP-beta-CD and RM-beta-CD and mucoadhesive polymers i.e., hydroxypropylmethylcellulose (HPMC) chitosan and hyaluronic acid (HA) were used. The phase solubility profiles and CCB/CD complex characteristics were investigated. RM-beta-CD exhibited the greatest solubilizer among CDs tested. HPMC was the potential polymer to form ternary complex with CCB/RM-beta-CD which gave 11-folds complexation efficiency higher than that of its binary complex. The aggregate size of ternary complexes in solution were found in the range of 250 - 350 nm which could solubilize themselves resulting in increasing CCB solubility. The data obtained from FT-IR, DSC, PXRD and 1H-NMR indicated that there were interaction of CCB with CD as inclusion complex. The CCB eye drops formulations were prepared by unheated and heating method (sonication at the temperature of 70oC for 1 hour). The physicochemical and chemical characterizations, mucoadhesive properties and in-vitro permeation were determined. The physicochemical properties i.e., appearance, pH, osmolality and viscosity were in acceptable range. The particle sizes below 10 µm indicated possibly no irritation to the eye. The formulation containing HA showed the excellent mucoadhesive properties. The increasing of % CCB content in most cases by heat resulting in higher flux permeation through semipermeable membrane and through simulated artificial vitreous humor, especially the formulation containing RM-beta-CD and HA (0.5% w/v). Therefore, it may be a promising candidate as topical formulation which can deliver CCB to the posterior segment of eye to treat AMD and DR.
DOI: 10.14457/cu.the.2016.710
title: In vitro biological properties of phyllanthus emblica, manilkara zapota extracts and their combinations for cosmetic applications

description: The changes in skin conditions involve several pathways. Natural extract has been included to improve the skin condition. However, single extract with several properties is barely available. The purpose of this study is to investigate the effect of individual amla and sapota fruit extracts and their combinations at the ratio of 5:1, 1:1 and 1:5 on in vitro antioxidant, anti-inflammatory, anti-collagenase, anti-elastase and anti-tyrosinase activities. The antioxidant and anti-inflammatory activities were determined by DPPH radical scavenging assay and by nitric oxide radical scavenging assay, respectively. Anti-collagenase, anti-elastase and anti-tyrosinase were analyzed by EnzChek® gelatinase/collagenase assay kit, EnzChek® elastase assay kit and DOPA chrome method, respectively. Ethanolic amla extract exhibited the strongest antioxidant and anti-inflammatory activities with IC50 of 1.84 ± 0.1 and 17.31 ± 0.37 µg/ml, respectively, while ethanolic sapota eaxtract revealed the highest anti-collagenase and anti-elastase activities with IC50 of 65.68 ± 3.63 and 36.82 ± 0.72 µg/ml, respectively. For anti-tyrosinase activity, sapota extract showed low activity with IC50 of 5862.52 ± 169.5 µg/ml whereas it was undetectable in amla extract. Combination amla and sapota extract at the ratio of 5:1, 1:1 and 1:5 provided antioxidant activity with IC50 of 2.21 ± 0.15, 3.13 ± 0.06 and 7.3 ± 0.73 µg/ml, respectively, and showed anti-inflammatory activity with IC50 of 19.72 ± 0.35, 31.14 ± 0.49 and 68.8 ± 1.35 µg/ml, respectively. Combination containing amla as a main constituent showed the highest activities. For anti-proteinase activity, their combination at the ratio of 5:1, 1:1 and 1:5 exhibited anti-collagenase activity with IC50 of 78.9 ± 3.42, 74.48 ± 1.61 and 68.68 ± 2.69 µg/ml, respectively, and revealed anti-elastase activity with IC50 of 150.72 ± 7.9, 71.9 ± 5.06 and 36.22 ± 0.99 µg/ml, respectively. Sapota showed a predominant in both activities and the combination which contained sapota as a main constituent exhibited the highest in both activities. The combination index (CI) at median condition of most combination ratios were exhibited additive effect, except combination 1:1 in antioxidant, combination 5:1 and 1:5 in anti-inflammatory, combination 5:1​ in anti-collagenase and combination 1:5 in anti-elastase activities which showed synergistic effect. Interestingly, combination 1:5 provided potent antioxidant and good anti-inflammatory activities from the effect of amla extract, moreover, it obtained effective anti-elastase and good anti-collagenase from the effect of sapota extract. This combination, therefore, may enhance overall cosmetic properties and may be further included as an active ingredient in cosmetic product.
DOI: 10.14457/cu.the.2019.108
title: Challenges of excise Tax reform in Myanmar : illegal alcohol market and method of charging on alcoholic beverages

description: Myanmar excise tax system is started from the British colonial regime. Excise tax system of Myanmar is complex and different from the other country. Myanmar excise tax system was reformed in several times. Before 2016, alcohol tax was collected as commercial tax. In 2016, the Specific Goods Tax Law was enacted and excise tax for alcoholic beverages has been named as specific goods tax under this law. According to this law excise tax was collected as specific goods tax. Reducing the alcohol consumption is one of the purposes of this law. This thesis analyses weaknesses of Myanmar excise tax system through comparative studying of Thailand and the Philippines excise tax system and tax laws.The Myanmar Government restricts alcohol importation to reduce alcohol consumption. It only allows for duty-free shops and hotels. However, foreign alcoholic beverages can be easily bought even in department stores in Myanmar. Most of the alcoholic beverages are come from the illegal channels. Thailand and the Philippines also restricted alcohol importation to their countries. The United States complained to the World Trade Organization relating to these import restrictions.Therefore, this thesis studies these two cases of alcohol importation. Moreover, causes and effects of illegal alcohol market are studied through several theories in order to find the way of minimizing the size of illegal alcohol market.
DOI: 10.25919/ymdy-p826
title: Parkes observations for project P1066 semester 2021APRS_09

description: We propose 36 hrs of Parkes observations to continue our successful Deeper, Wider, Faster (DWF) program to detect fast transients and fast radio burst (FRB) counterparts and help resolve their nature. DWF coordinates over 80 observatories worldwide at all wavelengths, from radio to gamma-ray to detect and follow-up FRBs and other elusive fast (millisecond-to-hours duration) transients. Crucially, we coordinate simultaneous deep, fast-cadenced, wide-field observations at all wavelengths to observe the same field at the same time as Parkes, enabling multi-wavelength detection before, during, and after the radio detection. Little to no multi-wavelength observations to any significant depth have been done on these timescales, leaving this parameter space underexplored. DWF coordinates major facilities to observe with Parkes, such as South Pole Telescope (mm/sub-mm), GROND (infrared), CTIO Dark Energy Camera (optical), Astrosat (UV/X-ray), HXMT (X-ray), HESS (gamma-ray), and Pierre Auger (high-energy). We perform realtime data processing and transient identification at all wavelengths that enables triggering our deep, rapid-response (within minutes) follow up programs for deep spectroscopy and imaging using the world's largest telescopes (e.g., Keck, VLT, Gemini, SALT, ATCA).
DOI: 10.14457/cu.the.1997.413
title: A study of sharkskin defect in linear-low density polyethylene
DOI: 10.14457/cu.the.1997.414
title: Methane conversion in an AC electric discharge
DOI: 10.14457/cu.the.1997.415
title: Characterization of Pd-Ag/AI2O3 selective acetylene/ethylene hydrogenation catalyst
DOI: 10.14457/cu.the.1997.416
title: Motor vehicle emissions : a major cause of lead poisoning among public school children of Kathmandu Valley, Nepal
DOI: 10.14457/cu.the.1997.417
title: Surfactant-enhanced carbon regeneration in vapor phase application
DOI: 10.14457/cu.the.1997.418
title: Developing a community profile on socio-economic and human behavioral aspects for improved malaria control in Nepal
DOI: 10.14457/cu.the.1997.419
title: Comparison of surface modified fillers to clay for natural rubber composites
DOI: 10.14457/cu.the.1997.420
title: Equilibrium precipitation of barium chromate from an aqueous solution of containing cationic polyelectrolyte
DOI: 10.14457/cu.the.1997.421
title: Information, education and communication issues concerning fertility regulation in Bhutan
DOI: 10.14457/cu.the.1997.422
title: Ambient temperature CO oxidation on the composite oxides supported silver catalysts
DOI: 10.14457/cu.the.1997.423
title: Propane dehydrogenation over lithium promoted platinum-tin catalysts:influence of promoters on decoking performance
DOI: 10.14457/cu.the.1997.424
title: UV-initiated polymerization of styrene in oil in water microemulsion
DOI: 10.14457/cu.the.1997.425
title: Time-temperature superposition of viscoelastic functions of PMMA/SAN blend at temperatures above and below Tg
DOI: 10.14457/cu.the.1997.426
title: Distribution of chlorinated alkanes between the coacervate and dilute aqueous phases induced by nonionic surfactants and comparison to solubilization in micelles
DOI: 10.14457/cu.the.1997.427
title: Application of polybenzoxazine for natural fiber reinforced plastics
DOI: 10.34740/kaggle/dsv/2608161
title: COVID Vaccination in World (updated daily)
DOI: 10.5517/ccdc.csd.cc2295l5
title: CCDC 1915446: Experimental Crystal Structure Determination

description: Related Article: Srikanta Jana, Joydeep Datta, Suvendu Maity, Baishali Thakurta, Partha Pratim Ray, Chittaranjan Sinha|2021|Cryst.Growth Des.|21|5240|doi:10.1021/acs.cgd.1c00581
DOI: 10.5517/ccdc.csd.cc230n3x
title: CCDC 1937038: Experimental Crystal Structure Determination

description: Related Article: Srikanta Jana, Joydeep Datta, Suvendu Maity, Baishali Thakurta, Partha Pratim Ray, Chittaranjan Sinha|2021|Cryst.Growth Des.|21|5240|doi:10.1021/acs.cgd.1c00581
DOI: 10.5517/ccdc.csd.cc27620k
title: CCDC 2061407: Experimental Crystal Structure Determination

description: Related Article: Erkam Cebi, Jan Klett|2021|Chem.-Eur.J.|27|12693|doi:10.1002/chem.202100912
DOI: 10.5517/ccdc.csd.cc27622m
title: CCDC 2061409: Experimental Crystal Structure Determination

description: Related Article: Erkam Cebi, Jan Klett|2021|Chem.-Eur.J.|27|12693|doi:10.1002/chem.202100912
DOI: 10.5517/ccdc.csd.cc27623n
title: CCDC 2061410: Experimental Crystal Structure Determination

description: Related Article: Erkam Cebi, Jan Klett|2021|Chem.-Eur.J.|27|12693|doi:10.1002/chem.202100912
DOI: 10.5517/ccdc.csd.cc27621l
title: CCDC 2061408: Experimental Crystal Structure Determination

description: Related Article: Erkam Cebi, Jan Klett|2021|Chem.-Eur.J.|27|12693|doi:10.1002/chem.202100912
DOI: 10.5517/ccdc.csd.cc27624p
title: CCDC 2061411: Experimental Crystal Structure Determination

description: Related Article: Erkam Cebi, Jan Klett|2021|Chem.-Eur.J.|27|12693|doi:10.1002/chem.202100912
DOI: 10.5517/ccdc.csd.cc27625q
title: CCDC 2061412: Experimental Crystal Structure Determination

description: Related Article: Erkam Cebi, Jan Klett|2021|Chem.-Eur.J.|27|12693|doi:10.1002/chem.202100912
DOI: 10.5517/ccdc.csd.cc27zk4y
title: CCDC 2084940: Experimental Crystal Structure Determination

description: Related Article: Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, Georgii I. Nikonov|2021|Inorg.Chem.|60|13110|doi:10.1021/acs.inorgchem.1c01518
DOI: 10.5517/ccdc.csd.cc27zk5z
title: CCDC 2084941: Experimental Crystal Structure Determination

description: Related Article: Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, Georgii I. Nikonov|2021|Inorg.Chem.|60|13110|doi:10.1021/acs.inorgchem.1c01518
DOI: 10.5517/ccdc.csd.cc27zk60
title: CCDC 2084942: Experimental Crystal Structure Determination

description: Related Article: Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, Georgii I. Nikonov|2021|Inorg.Chem.|60|13110|doi:10.1021/acs.inorgchem.1c01518
DOI: 10.5517/ccdc.csd.cc27zk71
title: CCDC 2084943: Experimental Crystal Structure Determination

description: Related Article: Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, Georgii I. Nikonov|2021|Inorg.Chem.|60|13110|doi:10.1021/acs.inorgchem.1c01518
DOI: 10.5517/ccdc.csd.cc27zk93
title: CCDC 2084945: Experimental Crystal Structure Determination

description: Related Article: Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, Georgii I. Nikonov|2021|Inorg.Chem.|60|13110|doi:10.1021/acs.inorgchem.1c01518
DOI: 10.5517/ccdc.csd.cc27zkb4
title: CCDC 2084946: Experimental Crystal Structure Determination

description: Related Article: Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, Georgii I. Nikonov|2021|Inorg.Chem.|60|13110|doi:10.1021/acs.inorgchem.1c01518
DOI: 10.5281/zenodo.5501870
title: Calidris melanotos SPAdes preassembly

description: .
DOI: 10.5281/zenodo.5501869
title: Calidris melanotos SPAdes preassembly

description: .
DOI: 10.7298/bzb0-eg69
title: New York State Wildlife Rehabilitator Logs 2012-2014
DOI: 10.6084/m9.figshare.14884845.v2
title: Hajj-Dataset 2021

description: This paper aims to propose an algorithms based on Convolutional Neural Networks (CNN) model specifically for Hajj applications. Additionally, the work introduces a system for counting and then estimating the crowd density. The model adopts an architecture which detects each person in the crowd, spotted head location with a bounding box and does the counting in our own created novel dataset (HAJJ-Crowd).
DOI: 10.6084/m9.figshare.14884845.v1
title: Hajj-Dataset 2021

description: This paper aims to propose an algorithms based on Convolutional Neural Networks (CNN) model specifically for Hajj applications. Additionally, the work introduces a system for counting and then estimating the crowd density. The model adopts an architecture which detects each person in the crowd, spotted head location with a bounding box and does the counting in our own created novel dataset (HAJJ-Crowd).
DOI: 10.5281/zenodo.5501895
title: Hydrozoanthus sils SPAdes preassembly

description: .
DOI: 10.5281/zenodo.5501894
title: Hydrozoanthus sils SPAdes preassembly

description: .
DOI: 10.6084/m9.figshare.14417225
title: Ti38V15Nb23Hf24

description: The training and validation dataset (in numpy format) for variational autoencoders based order parameter for Ti38V15Nb23Hf24 alloy. Each data sample is a system configuration with the sampled temperature provided in the corresponding label file. The configurations are generated with interaction parameters calculated from VASP v5.4.4 (input files included). <br>