cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/573d7zc4vn
title: Carbon Emission Accounting and Economic Growth in Nigeria

description: Abstract:This study investigated the relationship between carbon emission and economic growth in Nigeria for a period ranging from 1981-2018. The proxy for carbon emission is carbon dioxide CO2 and the proxy for economic growth is gross domestic product. The study used causal research design to mobilize data from the World Bank and Fact Fish publications while gross domestic product is sourced from the Central Bank of Nigeria Statistical Bulletin. The methods of descriptive statistics, Phillip-Perron, dynamic ordinary least Square and bivariate granger causality test are employed to analyze the data. The results show evidence of autoregressive effect of previous records of gross domestic product on its future value; there is an inverse relationship between carbon emission and gross domestic product. The bivariate granger causality confirms no existence of causality running between the variables. On the basis of the findings, the study concludes that there is an insignificant and negative relationship between carbon emission and Gross domestic product. It also concludes that CO2 and GDP are causally neutral to each other. It therefore recommends that earnest effort should be made by government to reduce greenhouse gas (GHG) in Nigeria by adhering to all relevant protocol and standards. Emissions not connected to the production of industrial and consumer goods should be taxed and avoided completely except the inevitable domestic emissions by practically applying the necessary laws both national and international. Precisely, focus should be shifted to going green in terms of energy generation, ensuring positive multiplier effect of constant power supply and the economics of clean air on the human health and productivity (PDF) Carbon Emission Accounting and Economic Growth in Nigeria. Available from: https://www.researchgate.net/publication/349238216_Carbon_Emission_Accounting_and_Economic_Growth_in_Nigeria [accessed May 19 2021].
DOI: 10.6084/m9.figshare.22664998.v2
title: The vertical distributions of soil microbial biomass and soil organic carbon across terrestrial ecosystems

description: The data were used for the global synthesis on the topic of the vertical distribution of microbial biomass carbon (MBC). The data were collected from 82 articles, covering 163 observations. <br> To quantify the vertical distribution patterns of MBC and SOC, we used an exponential decay function to fit MBC and SOC with soil depth: log10(Y)= -kd + m where Y is the MBC or SOC density (g cm-3) at depth d (midpoints of depth intervals, cm), k characterizes the relative decrease rate of MBC or SOC with depth, the greater k, the faster MBC or SOC decreases along the soil profile. m indicates the power of ten of MBC content at the soil surface. We used kMBC and kSOC to represent the rates of decrease in MBC and SOC, respectively. We square-root transformed kMBC and kSOC to make these two variables comparable and to facilitate visualization of the relationship.
DOI: 10.6084/m9.figshare.745318.v1
title: Platelet as a drug target for Dengue Haemorrhagic Fever

description: Abstract Dengue infection is the fastest spreading mosquito borne disease in the world. More than 2.5billion people spread over more than 100 countries are at risk. Thrombocytopenia is a key clinical feature and around 500,000 people annually develop the more severe form of this infection known as severe dengue (Dengue Haemorrhagic Fever/ Dengue Shock Syndrome). Platelets are key in the pathogenesis of severe dengue. Platelets have a cardinal role in haemostatic function and innate immunity, both of which are compromised in severe dengue. There are currently no drug treatments or vaccines available for dengue infection. The review highlights the role of platelets in humans and integrates the pathology seen in dengue with the known physiology. It also gives an insight on the drug targets being researched and why platelets should be considered as a drug target in dengue haemorrhagic fever. ( The section <strong>'Platelet conundrum'</strong> is the main section and should be read if there is a lack of time)
DOI: 10.17632/hp3xftsrfx
title: Data For: Home health care routing and scheduling problem with multiple time windows and multiple synchronized services

description: The test instances have been generated randomly using benchmark instances from Mankowska et al(2014). Four sets of instances are generated: • Single Service and Single Time Window (SSSTW); • Single Service and Multiple Time Windows (SSMTW); • Multiple Services and Single Time Window (MSSTW); • Multiple Services and Multiple Time Windows (MSMTW).
DOI: 10.17632/kskgnx8s9m
title: risk information disclosure and corporate innovation

description: △RiskDis:Difference in the number of risk keyword terms between the two years before and after the annual report ,△RiskDis2:Difference in the number of words of risk keywords between the two years before and after the annual report. △RiskDis3Difference in the number of risk keywords (only “risk” and “uncertainty”) between the two years before and after the annual report .Patcit: Logarithm of the total number of citations of patents of the enterprise in that year.Patnum:The logarithm of the total number of patent applications filed and granted by the enterprise in the year.
DOI: 10.17632/sbn6pgb68x
title: Supplemental Material for "Burden, risk factors and infectious complications of cellulitis and erysipelas in United States adults and children in the emergency department setting"

description: Supplemental Methods and Tables for "Burden, risk factors and infectious complications of cellulitis and erysipelas in United States adults and children in the emergency department setting"
DOI: 10.6084/m9.figshare.26224232.v8
title: <b>Sound-safety associative learning induces synaptic plasticity in the tail of striatum</b>

description: These excel sheets contain raw data required to produce the data in Stanley et al. 2024 "<b>Sound-safety associative learning induces synaptic plasticity in the tail of striatum</b>".
DOI: 10.6084/m9.figshare.6507437.v1
title: A 3D geological model of a structurally complex Alpine region as a basis for interdisciplinary research

description: Dataset representing a 3D geological reconstruction of the a section of the Nappe de Morlces, Switzerland. Associated with "A 3D geological model of a structurally complex Alpine region as a basis for interdisciplinary research" (Thornton et al.)
DOI: 10.6084/m9.figshare.8314217.v1
title: CYCB1;1:CYCB1;1-GFP tracking images

description: Images used for tracking CYCB1;1:CYCB1;1-GFP expression in WT and tcx2 mutant roots
DOI: 10.17632/33jctcjkd9
title: Geochemical data of selected Ferromanganese Crust Samples from Rio Grande Rise and Tropic Seamount

description: The dataset comprises geochemical results obtained from ICP-MS and ICP-OES analyses for both phosphatized and non-phosphatized layers of ferromanganese crust samples collected from Rio Grande Rise and Tropic Seamount.
The SF1 file encompasses all measurements conducted for the research, whereas the SF2 file presents the data obtained from ICP-OES and ICP-MS analyses
DOI: 10.17632/k9f4nfb7bn
title: Molecular Statistics (MST) Source Codes

description: These files contain the source codes for the Molecular Statistics Framework. 

Abstract:
This study presents Molecular Statistics (MST): a novel computational methodology designed to simulate thermodynamic properties of solid materials from room temperature to melting point with high efficiency. MST combines principles of statistical mechanics with molecular potentials, employing position distribution functions to generate atomic oscillations. Unlike conventional methods, MST enables fully independent and parallel calculations on small atomic sub-assemblies, reducing the computational load by orders of magnitude relative to molecular dynamics (MD) and Monte Carlo (MC) simulations. This approach bypasses the need for thermodynamic integration, directly sampling the Helmholtz free energy, which further minimizes computational expense. To validate MST, we benchmark its performance against state-of-the-art methods, including nonequilibrium molecular dynamics (NEMD), and the local harmonic approximation (LHA), a rapid yet less precise method. The evaluation demonstrates MST’s accuracy in predicting key thermodynamic properties, such as Gibbs free energy, entropy, and heat capacity, for several transition metals, aligning closely with experimental data. Furthermore, MST achieves these calculations within seconds, competitive with NEMD in both runtime and accuracy, underscoring its potential as an efficient alternative for high-temperature thermodynamic simulations. The MST framework thus emerges as a promising tool for materials science applications, particularly for complex systems where traditional methods become computationally prohibitive.

Please cite the following article, when using the codes: 
Vincent Feyen, Nele Moelans,
Molecular statistics: A novel computationally efficient modeling approach to simulate thermodynamic properties of solid materials up to the melting point,
Computational Materials Science,
Volume 248,
2025,
113558,
ISSN 0927-0256,
https://doi.org/10.1016/j.commatsci.2024.113558.
(https://www.sciencedirect.com/science/article/pii/S0927025624007791)
DOI: 10.17632/nhgbdhp2vy
title: Data for: A new spinosaurid theropod (Dinosauria: Megalosauroidea) from the late Barremian of Vallibona, Spain: Implications for spinosaurid diversity in the Early Cretaceous of the Iberian Peninsula

description: Datamatrix
DOI: 10.17632/s7y9ydz6nc
title: Supplemental Materials for Recurrence and Survival in Early-stage Acral Lentiginous Melanoma, A Retrospective Analysis

description: Table S1: Logistic regression model predicting distant vs. locoregional recurrence, amongst recurrent cases (N=111).

Table S2: Comparison of inadequate excision margins and recurrence patterns in the SSM (N=376) and ALM (N=110) cohorts with available margin data. Inadequate tumor margins refer to excision margins below the minimum recommendations by the American Joint Committee on Cancer.
DOI: 10.17632/v2wwzvrsyt
title: Data for: The Benefits of a Collaborative Care Agreement with Emergency Medicine Physicians and Clinical Pharmacists

description: Data set for The Benefits of a Collaborative Care Agreement with Emergency Medicine Physicians and Clinical Pharmacists
DOI: 10.17632/vdvdrj3k2p
title: Dataset: Classification of bacterial nanowire proteins using Machine Learning and feature engineering model

description: Dataset: Classification of bacterial nanowire proteins using Machine Learning and feature engineering model
DOI: 10.6084/m9.figshare.16770895.v1
title: Data Availability Sheet for Space-Saving Multipurpose Table

description: Dataset for tests and surveys done with the space-saving multipurpose table for improved ergonomic performance.
DOI: 10.6084/m9.figshare.21108010.v1
title: SupData.pdf

description: Supplemental materiel for submitted article
DOI: 10.6084/m9.figshare.23269331.v1
title: Supplementary Material for: Hypertrophic pachymeningitis with persistent intrathecal inflammation secondary to neurosarcoidosis treated with intraventricular chemotherapy: a case report

description: Background: Hypertrophic pachymeningitis (HP) is a rare immune-mediated disease characterized by thickening of the dura mater with consecutive cranial neuropathy. While HP is usually treated with systemic immunotherapies, response to therapy is variable and may be limited by insufficient drug concentrations in the brain. We report on a patient with HP and marked lymphocytic pleocytosis refractory to various systemic immunotherapies, who was treated with intraventricular chemotherapy. Methods: A 57-year-old patient with HP manifesting with vision and hearing loss had sustained clinical progression despite various systemic immunotherapies. Intraventricular chemotherapy with methotrexate, cytarabine and dexamethasone was initiated. We present clinical, imaging and cerebrospinal fluid (CSF) findings, including cytokine levels before and after intraventricular treatment. Results: Rapid decrease of cell count, lactate and pro-fibrotic cytokine levels in the CSF following intraventricular chemotherapy was paralleled by a mild reduction of dura thickness in MRI. The already severely impaired visual acuity and hearing loss did not progress further. Treatment was complicated by exacerbation of previously subtle psychiatric symptoms. Follow-up was terminated after 6 months as the patient suffered from a fatal ischemic stroke. Autopsy revealed neurosarcoidosis as the underlying cause of HP. Conclusion: This case report suggests that intrathecal chemotherapy can reduce the inflammatory milieu in the CNS and should be considered for treatment-refractory HP before irreversible damage of cranial nerves has occurred.
DOI: 10.17632/9cr3pppc26
title: Supplementary material for "Bedsore healing using selenium-enriched Lactobacillus brevis LSe: A randomized, double-blind, controlled clinical trial"

description: Supplementary material for "Bedsore healing using selenium-enriched Lactobacillus brevis LSe: A randomized, double-blind, controlled clinical trial" including 3 tables and 2 figures.
DOI: 10.6084/m9.figshare.14101544.v1
title: Supplementary Material for: The Pharmacokinetics of Caffeine in Preterm Newborns: No Influence of Doxapram but Important Maturation with Age

description: <b><i>Background:</i></b> Apnea of prematurity can persist despite caffeine therapy in preterm infants. Doxapram may additionally support breathing. Although multiple small studies have reported the efficacy of doxapram, the structural co-treatment with caffeine impedes to ascribe the efficacy to doxapram itself or to a pharmacokinetic (PK) interaction where doxapram increases the exposure to caffeine. We examined whether there is a PK drug-drug interaction between doxapram and caffeine by developing a PK model for caffeine including infants with and without doxapram treatment. <b><i>Methods:</i></b> In preterm neonates receiving caffeine, we determined caffeine plasma concentrations before, during, and directly after doxapram co-treatment and used these to develop a population PK model in NONMEM 7.3. Patient characteristics and concomitant doxapram administration were tested as covariates. <b><i>Results:</i></b> 166 plasma samples were collected from 39 preterm neonates receiving caffeine (median gestational age 25.6 [range 24.0–28.0] weeks) of which 65 samples were taken during co-treatment with doxapram (39%, from 32/39 infants). Clearance of caffeine was 9.99 mL/h for a typical preterm neonate with a birth weight of 0.8 kg and 23 days postnatal age and increased with birth weight and postnatal age, resulting in a 4-fold increase in clearance during the first month of life. No PK interaction between caffeine and doxapram was identified. <b><i>Discussion:</i></b> Caffeine clearance is not affected by concomitant doxapram therapy but shows a rapid maturation with postnatal age. As current guidelines do not adjust the caffeine dose with postnatal age, decreased exposure to caffeine might partly explain the need for doxapram therapy after the first week of life.
DOI: 10.6084/m9.figshare.27924426.v3
title: Data for Shima Cave samples during Ice Age Termination II.xlsx

description: Stalagmite oxygen isotope data (δ<sup>18</sup>O and Δʹ<sup>17</sup>O) for samples (SM9, SM12, SM16 and SM17) from Shima Cave, Hunan Province, central China.
DOI: 10.6084/m9.figshare.28638965.v1
title: Supplementary Material for: Treatment satisfaction and treatment wishes of patients with chronic cancer-related pain

description: Purpose 
Up to 40% of long-term cancer survivors suffer from chronic cancer-related pain (CCRP) with often inadequate treatment. CCRP is influenced by biopsychosocial factors, with interdisciplinary multimodal pain therapy (IMPT) being a comprehensive treatment option. In our study, patients with CCRP were asked about their treatment satisfaction and treatment wishes. 

Methods
Two anonymous online surveys on CCRP in long-term survivors were analyzed: Survey 1 from cancer self-help group members and Survey 2 from patients with CCRP assessed at the Interdisciplinary Pain Centre (IPC), resulting in recommendations ranging from outpatient treatment to IMPT. 

Results
38 members of 8 self-help groups in Survey 1 and 50 of 158 patients with CCRP in Survey 2 completed the questionnaire. In both surveys, relevant pain impairment and pain therapy dissatisfaction were identified. A higher intensity of therapy, including the implementation of IMPT, did not lead to better pain control. Consistent with the biopsychosocial factors in CCRP, increased depression scores and increased treatment dissatisfaction correlated. In both surveys participants expressed extensive therapy wishes. 

Conclusions
Despite comprehensive therapeutic approaches, long-term survivors with CCRP suffer from severe pain and treatment dissatisfaction. Biopsychosocial influences are evident, with depression worsening treatment satisfaction. Classical IMPT for CCRP may not be targeted enough and a more specific therapeutic approach should be developed and must be tested using PROMs (patient-reported outcome measures).
DOI: 10.6084/m9.figshare.3241672.v5
title: A brief description of general TLR signaling pathway

description: <b>A general overview of TLR signaling pathways. </b>The full names of proteins shown in the figure are as follows. MyD88: Myeloid differentiation primary response protein 88; TIRAP: TIR-domain-containing adaptor protein; IRAK1: IL-1R-associated kinase 1; TRAF6: Tumor-necrosis-factor receptor-associated factor 6; IKK: Inhibitor of nuclear factor-κB (IκB)-kinase; IRF3: Interferon regulatory factor 3; TBK1: TRAF family member-associated NF-kappa-B activator (TANK) binding kinase; TRIF: TIR domain-containing adaptor–inducing interferon-β; TRAM: TRIF-related adaptor molecule. Two different but simultaneous pathways of signal transduction are known by which TLRs activate an adaptive immune response. One is through the adaptor MyD88, which is used by all TLRs except for TLR3. TLR3 operates through the TRIF pathway. TLR4 signals through both TRIF and MyD88 pathways. In the MyD88 pathway (also called the canonical pathway), conformational alteration of TLR homo/heterodimers allows binding of the TLR-TIR domain to the MyD88-TIR domains through homotypic TIR-TIR interaction. Subsequently, MyD88 recruits the kinase IRAK4 by death domain (DD)-DD interactions. IRAK4 binds and phosphorylates IRAK1, a natural substrate of IRAK4. Phosphorylated IRAK1 brings TRAF6 to the receptor complex. TRAF6 and IRAK1 dissociate from the receptor complex and form another complex with transforming growth factor β activated kinase 1 (TAK1), which coexists with the adaptor TAK1-binding protein 2 (TAB2) and activator TAB1 at the plasma membrane. IRAK1 phosphorylates both TAB1 and TAK1, and is degraded afterward, facilitating the translocation of TRAF6, TAK1, TAB1, and TAB2 to the cytoplasm where ubiquitin-conjugating enzyme 13 (UBC13) and ubiquitin-conjugating enzyme E2 variant 1 (UEV1A) ubiquitinate TRAF6, inducing activation of TAK1. Next, TAK1 phosphorylates mitogen-activated protein kinase (MAPK) and IKK complexes. The IKK complex, in turn, phosphorylates the IκB subunit of NF-κB, leading to its ubiquitination and subsequent degradation. This allows nuclear translocation of NF-κB to induce transcription of target genes. MyD88 works in concert with an upstream DD-lacking adaptor TIRAP, also called MyD88 adaptor-like (MAL), particularly during TLR1/2, 2/6, and TLR4 signaling. The TRIF pathway, also called the MyD88-independent or alternate signaling pathway, is specifically activated by TLR3 and TLR4. TRIF, along with a second, upstream adaptor, TRAM, stimulates IKK-ε and TBK1. IKK-ε, the counterpart of IKK in the canonical pathway, and TBK1 mediate activation and nuclear translocation of IRF3 to induce transcription of antiviral IFNs.<b></b>The figure was redrawn from the published paper (own: http://dx.doi.org/10.1080/13543776.2016.1185415). The figure is uploaded in Wikicommons https://commons.wikimedia.org/wiki/File:TLR_Signaling_pathway.tif
DOI: 10.6084/m9.figshare.24083769.v1
title: Supplementary Material for: IS THERE ANY RISK FOR METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH PSYCHIATRIC DISORDERS?

description: Objective: We aimed to investigate the risk of antipsychotic drug treatment in the development of metabolic syndrome (MetS) in children and adolescents and to determine which psychiatric disorder is more associated with MetS in the pediatric population. Methods: The sample consisted of 118 children and adolescents (88 used psychotropic medication). The hemogram, fasting blood glucose, lipid profile, weight, and blood pressure levels from all the participants and information regarding medication doses of the patient group at the sixth month of the treatment process were obtained. Results: Bipolar Disorder (BPD) was the only psychiatric disorder associated with MetS. Quetiapine and Valproic acid were found to have increasing effects on MetS. Weight gain and the increase in systolic and diastolic blood pressure significantly increased the likelihood of MetS. Hierarchical logistic regression analyses revealed that quetiapine increased the risk of metabolic syndrome through weight gain, and valproic acid increased metabolic syndrome risk through systolic blood pressure. Conclusion: Especially BPD and psychotropic use in children and adolescents disrupt metabolic regulation and pose a risk for MetS. Determining the risk factors causing MetS, especially in children and adolescents, plays a significant role in preventing mortality and morbidity at advanced ages.
DOI: 10.6084/m9.figshare.19191227.v1
title: multilayer structure paper

description: for data availability
DOI: 10.6084/m9.figshare.14545752.v1
title: Supplementary Material for: Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis

description: <b><i>Background:</i></b> Most phase 3 clinical trials of systemic therapy for first-line unresectable hepatocellular carcinoma (HCC) have failed, with the exception of SHARP, REFLECT, and IMbrave150. We conducted indirect comparisons of therapies evaluated for first-line HCC treatment. <b><i>Summary:</i></b> We conducted a systematic review and meta-analysis of treatments for adults with locally advanced or metastatic unresectable HCC and no prior systemic treatment, including atezolizu­mab plus bevacizumab, sorafenib, lenvatinib, nivolumab, selective internal radiotherapy (SIRT), transarterial chemoembolization, and placebo or best supportive care. Randomized controlled trials published from January 1, 2007, to March 12, 2020, were retrieved from MEDLINE and Embase. Qualitative assessment of heterogeneity evaluated study designs, populations, and outcomes. Indirect comparisons used generalized linear models with random effects within a Bayesian framework and informative priors. We calculated relative efficacy estimates with 95% credible intervals (CrIs) and Bayesian posterior probability estimates of atezolizumab-bevacizumab being superior to other treatments. Nine clinical studies with a total of 3,897 participants were identified from 8,783 records and used to build the all-trials evidence network. Indirect comparisons suggested an improved overall survival (OS) with atezolizumab-bevacizumab versus lenvatinib (odds ratio, 0.63 [95% CrI 0.39–1.04]; with 97% Bayesian posterior probability of being superior), nivolumab (0.68 [95% CrI 0.41–1.14]; 94%), sorafenib (0.59 [95% CrI 0.39–0.87]; 99%), SIRT (0.51 [95% CrI 0.32–0.82]; 100%), or placebo/best supportive care (0.40 [95% CrI 0.25–0.64]; 100%). <b><i>Key Messages:</i></b> Within the context of indirect comparisons, analyses of OS favored atezolizumab-bevacizumab versus other treatment options for patients with locally advanced or metastatic unresectable HCC.