cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14761608
title: Supplementary Material for: Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage

description: <b><i>Introduction:</i></b> The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in CKD patients with type 2 diabetes. Clinical data analyzing the potential value of a combination therapy are currently limited. We therefore investigated cardiorenal protection of respective mono- and combination therapy in a preclinical model of hypertension-induced end-organ damage. <b><i>Methods:</i></b> Cardiovascular (CV) morbidity and mortality were studied in hypertensive, N(ω)-nitro-L-arginine methyl ester-treated, renin-transgenic (mRen2)27 rats. Rats (10- to 11-week-old females, <i>n</i> = 13–17/group) were treated once daily orally for up to 7 weeks with placebo, finerenone (1 and 3 mg/kg), empagliflozin (3 and 10 mg/kg), or a combination of the respective low doses. Key outcome parameters included mortality, proteinuria, plasma creatinine and uric acid, blood pressure, and cardiac and renal histology. <b><i>Results:</i></b> Placebo-treated rats demonstrated a 50% survival rate over the course of 7 weeks. Drug treatment resulted in variable degrees of survival benefit, most prominently in the low-dose combination group with a survival benefit of 93%. Monotherapies of finerenone or empagliflozin dose-dependently reduced proteinuria, while low-dose combination revealed an early, sustained, and over-additive reduction in proteinuria. Empagliflozin induced a strong and dose-dependent increase in urinary glucose excretion which was not influenced by finerenone coadministration in the combination arm. Low-dose combination but not respective low-dose monotherapies significantly reduced plasma creatinine and plasma uric acid after 6 weeks. Treatment with finerenone and the low-dose combination significantly decreased systolic blood pressure after 5 weeks. There was a dose-dependent protection from cardiac and kidney fibrosis and vasculopathy with both agents, while low-dose combination therapy was more efficient than the respective monotherapy dosages on most cardiorenal histology parameters. <b><i>Discussion/Conclusions:</i></b> Nonsteroidal MR antagonism by finerenone and SGLT2 inhibition by empagliflozin confer CV protection in preclinical hypertension-induced cardiorenal disease. Combination of these 2 independent modes of action at low dosages revealed efficacious reduction in important functional parameters such as proteinuria and blood pressure, plasma markers including creatinine and uric acid, cardiac and renal lesions as determined by histopathology, and mortality indicating a strong potential for combined clinical use in cardiorenal patient populations.
DOI: 10.6084/m9.figshare.14761608.v1
title: Supplementary Material for: Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage

description: <b><i>Introduction:</i></b> The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in CKD patients with type 2 diabetes. Clinical data analyzing the potential value of a combination therapy are currently limited. We therefore investigated cardiorenal protection of respective mono- and combination therapy in a preclinical model of hypertension-induced end-organ damage. <b><i>Methods:</i></b> Cardiovascular (CV) morbidity and mortality were studied in hypertensive, N(ω)-nitro-L-arginine methyl ester-treated, renin-transgenic (mRen2)27 rats. Rats (10- to 11-week-old females, <i>n</i> = 13–17/group) were treated once daily orally for up to 7 weeks with placebo, finerenone (1 and 3 mg/kg), empagliflozin (3 and 10 mg/kg), or a combination of the respective low doses. Key outcome parameters included mortality, proteinuria, plasma creatinine and uric acid, blood pressure, and cardiac and renal histology. <b><i>Results:</i></b> Placebo-treated rats demonstrated a 50% survival rate over the course of 7 weeks. Drug treatment resulted in variable degrees of survival benefit, most prominently in the low-dose combination group with a survival benefit of 93%. Monotherapies of finerenone or empagliflozin dose-dependently reduced proteinuria, while low-dose combination revealed an early, sustained, and over-additive reduction in proteinuria. Empagliflozin induced a strong and dose-dependent increase in urinary glucose excretion which was not influenced by finerenone coadministration in the combination arm. Low-dose combination but not respective low-dose monotherapies significantly reduced plasma creatinine and plasma uric acid after 6 weeks. Treatment with finerenone and the low-dose combination significantly decreased systolic blood pressure after 5 weeks. There was a dose-dependent protection from cardiac and kidney fibrosis and vasculopathy with both agents, while low-dose combination therapy was more efficient than the respective monotherapy dosages on most cardiorenal histology parameters. <b><i>Discussion/Conclusions:</i></b> Nonsteroidal MR antagonism by finerenone and SGLT2 inhibition by empagliflozin confer CV protection in preclinical hypertension-induced cardiorenal disease. Combination of these 2 independent modes of action at low dosages revealed efficacious reduction in important functional parameters such as proteinuria and blood pressure, plasma markers including creatinine and uric acid, cardiac and renal lesions as determined by histopathology, and mortality indicating a strong potential for combined clinical use in cardiorenal patient populations.
DOI: 10.6084/m9.figshare.14761578
title: original data.xlsx

description: 东北某玉米田黑土连续施用阿特拉津对土壤酶和微生物多样性的动态响应
DOI: 10.6084/m9.figshare.14761578.v1
title: original data.xlsx

description: 东北某玉米田黑土连续施用阿特拉津对土壤酶和微生物多样性的动态响应
DOI: 10.5281/zenodo.4922429
title: Data for the multi-carrier market based simulations (WP 6) - gas and heat orders

description: Data for the multi-carrier market based simulations (WP 6) - gas and heat orders
DOI: 10.5281/zenodo.4922428
title: Data for the multi-carrier market based simulations (WP 6) - gas and heat orders

description: Data for the multi-carrier market based simulations (WP 6) - gas and heat orders
DOI: 10.6084/m9.figshare.14551425.v1
title: The transcriptome assembly, unigenes, FPKM value of unigens and functional annotation of Arisaema erubescens

description: The transcriptome assembly, unigenes, FPKM value of unigens and functional annotation of Arisaema erubescens
DOI: 10.17909/t9-wwkt-gv03
title: WFPC2 data used in MAPS XIX

description: WFPC2 data used in Molecules with ALMA at Planet-forming Scales (MAPS) XIX. Spiral Arms, a Tail, and Diffuse Structures Traced by CO around the GM Aur Disk
DOI: 10.6084/m9.figshare.14758464
title: f.FHIST.f09_f09_mg17.NORES.005

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758464.v1
title: f.FHIST.f09_f09_mg17.NORES.005

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758461
title: f.FHIST.f09_f09_mg17.NORES.004

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758467.v1
title: i.IHistClm50Sp.f09_g17.CTL

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758470
title: i.IHistClm50Sp.f09_g17.transRES

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758467
title: i.IHistClm50Sp.f09_g17.CTL

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758458
title: f.FHIST.f09_f09_mg17.NORES.003

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758470.v1
title: i.IHistClm50Sp.f09_g17.transRES

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758452
title: f.FHIST.f09_f09_mg17.NORES.001

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758458.v1
title: f.FHIST.f09_f09_mg17.NORES.003

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758455.v1
title: f.FHIST.f09_f09_mg17.NORES.002

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758455
title: f.FHIST.f09_f09_mg17.NORES.002

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758437
title: f.FHIST.f09_f09_mg17.CTL.003

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758452.v1
title: f.FHIST.f09_f09_mg17.NORES.001

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758428.v1
title: f.FHIST.f09_f09_mg17.CTL.002

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758428
title: f.FHIST.f09_f09_mg17.CTL.002

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758437.v1
title: f.FHIST.f09_f09_mg17.CTL.003

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758422
title: f.FHIST.f09_f09_mg17.CTL.001

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758440
title: f.FHIST.f09_f09_mg17.CTL.004

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758422.v1
title: f.FHIST.f09_f09_mg17.CTL.001

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758440.v1
title: f.FHIST.f09_f09_mg17.CTL.004

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.5281/zenodo.4922450
title: A genomic exploration of the early evolution of extant cats and their sabre-toothed relatives - extended data

description: Extended data for the manuscript - Westbury et al., A genomic exploration of the early evolution of extant cats and their sabre-toothed relatives. This includes both supplementary figures and tables.
DOI: 10.5281/zenodo.4434075
title: A genomic exploration of the early evolution of extant cats and their sabre-toothed relatives - extended data

description: Extended data for the manuscript - Westbury et al., A genomic exploration of the early evolution of extant cats and their sabre-toothed relatives. This includes both supplementary figures and tables.
DOI: 10.6084/m9.figshare.14758476
title: surfdata

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758476.v1
title: surfdata

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.5281/zenodo.4922417
title: Individual haplotyping of whale sharks from seawater environmental DNA

description: WS### files each contain 4 files (2x F and R) for the tissue samples. WSlib# files contain raw MiSeq data (F and R) for each of the four replicate libraries.
DOI: 10.5281/zenodo.4108077
title: Individual haplotyping of whale sharks from seawater environmental DNA

description: WS### files each contain 4 files (2x F and R) for the tissue samples. WSlib# files contain raw MiSeq data (F and R) for each of the four replicate libraries.
DOI: 10.6084/m9.figshare.13326044
title: Quickly locating POIs in large datasets from descriptions based on improved address matching and compact qualitative representations

description: The data and codes that support the findings of the study.
DOI: 10.6084/m9.figshare.13326044.v2
title: Quickly locating POIs in large datasets from descriptions based on improved address matching and compact qualitative representations

description: The data and codes that support the findings of the study.
DOI: 10.6084/m9.figshare.13326044.v1
title: Locating POIs in a large area from descriptions of qualitative directions and quantitative distances

description: The data and codes that support the findings of the study.
DOI: 10.5281/zenodo.4922464
title: Study of the genetic and phenotypic variation among wild and cultivated clary sages provides interesting avenues for breeding programs of a perfume, medicinal and aromatic plant

description: A road-map of the genetic and phenotypic diversities in both crops and their wild-related species can help identifying valuable genetic resources for further crop breeding. The clary sage (<em>Salvia sclarea L.</em>), a perfume, medicinal and aromatic plant, is used for sclareol production and ornamental purposes. Despite its wide use in the field of cosmetics, the phenotypic and genetic diversity of wild and cultivated clary sage remains to be explored. We characterized the genetic and phenotypic variation of a collection of six wild <em>S. sclarea</em> populations from Croatia, sampled along an altitudinal gradient, and of populations of three <em>S. sclarea</em> cultivars. We showed low level of genetic diversity for the two <em>S. sclarea</em> traditional cultivars used for essential oil production and for ornamental purposes, respectively. In contrast, a recent cultivar resulting from new breeding methods, which involve hybridizations among several genotypes rather than traditional recurrent selection and self-crosses over time, showed high genetic diversity. We also observed a marked phenotypic differentiation for the ornamental clary sage compared with other cultivated and wild clary sages. Instead, the two cultivars used for essential oil production, a traditional and a recent, respectively, were not phenotypically differentiated from the wild Croatian populations. Our results also featured some wild populations with high sclareol content and early-flowering phenotypes as good candidates for future breeding programs. This study opens up perspectives for basic research aiming at understanding the impact of breeding methods on clary sage evolution, and highlights interesting avenues for clary breeding programs.
DOI: 10.5281/zenodo.4922463
title: Study of the genetic and phenotypic variation among wild and cultivated clary sages provides interesting avenues for breeding programs of a perfume, medicinal and aromatic plant

description: A road-map of the genetic and phenotypic diversities in both crops and their wild-related species can help identifying valuable genetic resources for further crop breeding. The clary sage (<em>Salvia sclarea L.</em>), a perfume, medicinal and aromatic plant, is used for sclareol production and ornamental purposes. Despite its wide use in the field of cosmetics, the phenotypic and genetic diversity of wild and cultivated clary sage remains to be explored. We characterized the genetic and phenotypic variation of a collection of six wild <em>S. sclarea</em> populations from Croatia, sampled along an altitudinal gradient, and of populations of three <em>S. sclarea</em> cultivars. We showed low level of genetic diversity for the two <em>S. sclarea</em> traditional cultivars used for essential oil production and for ornamental purposes, respectively. In contrast, a recent cultivar resulting from new breeding methods, which involve hybridizations among several genotypes rather than traditional recurrent selection and self-crosses over time, showed high genetic diversity. We also observed a marked phenotypic differentiation for the ornamental clary sage compared with other cultivated and wild clary sages. Instead, the two cultivars used for essential oil production, a traditional and a recent, respectively, were not phenotypically differentiated from the wild Croatian populations. Our results also featured some wild populations with high sclareol content and early-flowering phenotypes as good candidates for future breeding programs. This study opens up perspectives for basic research aiming at understanding the impact of breeding methods on clary sage evolution, and highlights interesting avenues for clary breeding programs.
DOI: 10.6084/m9.figshare.14761707.v1
title: the BSP of DLK1_R .zip

description: This is the sequencing data about the methylation level of DLK1_R in 25 TOF patients and 5 controls.
DOI: 10.6084/m9.figshare.14758461.v1
title: f.FHIST.f09_f09_mg17.NORES.004

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758446.v1
title: f.FHIST.f09_f09_mg17.CTL.005

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.6084/m9.figshare.14758446
title: f.FHIST.f09_f09_mg17.CTL.005

description: CESM simulation used in Vanderkelen et al., (2021).
DOI: 10.5281/zenodo.4626590
title: The dEchorate dataset

description: This work presents a new dataset of measured multichannel Room Impulse Responses (RIRs) named dEchorate. It includes annotations of early echo timings and 3D positions of microphones, real sources and image sources under different wall configurations in a cuboid room.<br> These data provide a tool for benchmarking recent methods in echo-aware speech enhancement, room geometry estimation, RIR estimation, acoustic echo retrieval, microphone calibration, echo labelling and reflectors position estimation.<br> The dataset is provided with software utilities to easily access, manipulate and visualize the data as well as baseline methods for echo-related tasks. Paper | Code
DOI: 10.5281/zenodo.4009129
title: SciGRID_gas IGG

description: The IGG dataset is a collection of open source European gas transport data produced by SciGRID_gas team.<br> The data set contains geographical and meta information on the European gas transport network.<br> The data results from the merged data sets of INET_raw, GIE and GSE data and heuristic process to fill missing parameter values.
DOI: 10.5281/zenodo.4009128
title: SciGRID_gas IGG

description: The IGG dataset is a collection of open source European gas transport data produced by SciGRID_gas team.<br> The data set contains geographical and meta information on the European gas transport network.<br> The data results from the merged data sets of INET_raw, GIE and GSE data and heuristic process to fill missing parameter values.
DOI: 10.5281/zenodo.4917565
title: Code and data for: "Birds use individually consistent temperature cues to time their migration departure "

description: This is the code and data used for the publication:<br> Burnside, R. J Salliss,, D., Collar N.J., & Dolman, P. M. (2021) Birds use individually consistent temperature cues to time their migration departure. <strong>Proceedings of the National Academy of Sciences</strong>. The archive consists of:<br> (1) R script to repeat the core results of the analyses performed in the study.<br> (2) The migration datasets contained in an xlsx file with five sheets:<br> - spring migration departure and arrival data<br> - autumn migration departure and arrival data<br> - 1000 null datasets for the spring migration with the data shuffled. <br> - a table with a list of two-way comparisons used in the R script. <br> - explanations of column headings. Please see the PNAS publication for more details, or contact me at robertjohnburnside@hotmail.com with any questions regarding the code or data. When using this code or data, please attribute/cite this dataset appropriately using the doi as well as the original publication in PNAS.
DOI: 10.5281/zenodo.4655819
title: Code and data for: "Birds use individually consistent temperature cues to time their migration departure "

description: This is the code and data used for the publication:<br> Burnside, R. J Salliss,, D., Collar N.J., & Dolman, P. M. (2021) Birds use individually consistent temperature cues to time their migration departure. <strong>Proceedings of the National Academy of Sciences</strong>. The archive consists of:<br> (1) R script to repeat the core results of the analyses performed in the study.<br> (2) The migration datasets contained in an xlsx file with five sheets:<br> - spring migration departure and arrival data<br> - autumn migration departure and arrival data<br> - 1000 null datasets for the spring migration with the data shuffled. <br> - a table with a list of two-way comparisons used in the R script. <br> - explanations of column headings. Please see the PNAS publication for more details, or contact me at robertjohnburnside@hotmail.com with any questions regarding the code or data. When using this code or data, please attribute/cite this dataset appropriately using the doi as well as the original publication in PNAS.
DOI: 10.6084/m9.figshare.14761794
title: Supplementary Material for: Impact of Physician Training Level on Neonatal Tracheal Intubation Success Rates and Adverse Events: A Report from National Emergency Airway Registry for Neonates (NEAR4NEOS)

description: <b><i>Introduction:</i></b> Neonatal tracheal intubation (TI) outcomes have been assessed by role, but training level may impact TI success and safety. Effect of physician training level (PTL) on the first-attempt success, adverse TI-associated events (TIAEs), and oxygen desaturation was assessed. <b><i>Methods:</i></b> Prospective cohort study in 11 international NEAR4NEOS sites between October 2014 and December 2017. Primary TIs performed by pediatric/neonatal physicians were included. Univariable analysis evaluated association between PTL, patient/practice characteristics, and outcomes. Multivariable analysis with generalized estimating equation assessed for independent association between PTL and outcomes (first-attempt success, TIAEs, and oxygen desaturation ≥20%; attending as reference). <b><i>Results:</i></b> Of 2,608 primary TIs, 1,298 were first attempted by pediatric/neonatal physicians. PTL was associated with patient age, weight, comorbidities, TI indication, difficult airway history, premedication, and device. First-attempt success rate differed across PTL (resident 23%, fellow 53%, and attending 60%; <i>p</i> &lt; 0.001). There was no statistically significant difference in TIAEs (resident 22%, fellow 20%, and attending 25%; <i>p</i> = 0.34). Desaturation occurred more frequently with residents (60%), compared to fellows and attendings (46 and 53%; <i>p</i> &lt; 0.001). In multivariable analysis, adjusted odds ratio of the first-attempt success was 0.18 (95% CI: 0.11–0.30) for residents and 0.80 (95% CI: 0.51–1.24) for fellows. PTL was not independently associated with adjusted odds of TIAEs or severe oxygen desaturation. <b><i>Conclusion:</i></b> Higher PTL was associated with increased first-attempt success but not TIAE/oxygen desaturation. Identifying strategies to decrease adverse events during neonatal TI remains critical.