cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19901589
title: A PROPOSITION FOR TEACHING LABORATORY OF QUALITATIVE ANALYTICAL CHEMISTRY.

description: Teaching laboratory of qualitative analytical chemistry is still a controversial issue in chemistry courses. However, important researchers and educators in chemistry recognized and highlighted the importance that the contents of this discipline represent in the formation of chemists, once it can provide handling and understanding of microscopic phenomena based on the observation of their macroscopic effects, once such reactions and phenomena are the basis of important instrumental methods of analysis. Thus, a proposal based on a bottom-up approach has been developed, starting with the observation of different reactions of cations in laboratory, followed by a search for the reaction responsible for each resulting phenomenon observed during the experimental step. Then these reactions are related with the separation procedures of each group of cations. Eventually the separation of these groups can also be performed depending on the time available. The proposal has been applied in teaching laboratory of qualitative analytical chemistry at Instituto de Química de São Carlos/USP since 2015, where the discipline is offered duirng 4 hours/week, and a positive feedback regarding the evolution of the methodology and its acceptance by students. Good results were also obtained concerning the appropriation of the contents by the students, using the proposal.
DOI: 10.6084/m9.figshare.19901589.v1
title: A PROPOSITION FOR TEACHING LABORATORY OF QUALITATIVE ANALYTICAL CHEMISTRY.

description: Teaching laboratory of qualitative analytical chemistry is still a controversial issue in chemistry courses. However, important researchers and educators in chemistry recognized and highlighted the importance that the contents of this discipline represent in the formation of chemists, once it can provide handling and understanding of microscopic phenomena based on the observation of their macroscopic effects, once such reactions and phenomena are the basis of important instrumental methods of analysis. Thus, a proposal based on a bottom-up approach has been developed, starting with the observation of different reactions of cations in laboratory, followed by a search for the reaction responsible for each resulting phenomenon observed during the experimental step. Then these reactions are related with the separation procedures of each group of cations. Eventually the separation of these groups can also be performed depending on the time available. The proposal has been applied in teaching laboratory of qualitative analytical chemistry at Instituto de Química de São Carlos/USP since 2015, where the discipline is offered duirng 4 hours/week, and a positive feedback regarding the evolution of the methodology and its acceptance by students. Good results were also obtained concerning the appropriation of the contents by the students, using the proposal.
DOI: 10.6084/m9.figshare.19901601
title: Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study

description: Abstract Introduction: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COVID-19 in KT recipients according to Brazilian geographic regions. Methods: This multicenter national retrospective analysis included data from KT recipients with confirmed COVID-19 between March and November 2020. Results: Thirty-five of the 81 centers (57% of KT activity in Brazil) reported 1,680 patients with COVID-19. The Northeast was the first to reach the peak in the number of infections. The Southeast, due to its population density, contributed with the largest number of patients. Patients had a median age of 52 years, 76% had hypertension and 34% diabetes, 75% were recipients of a deceased donor, and the time interval between diagnosis and transplantation was 5.9 years. In 53% of patients, immunosuppression was adjusted, and clinical support varied according to geographic region. Hospitalization was required for 65% of the patients, 35% of them needed intensive care, 25% mechanical ventilation, and 23% renal replacement therapy. The 90-day overall fatality was 21%, being 23% in the Southeast, 16% in the Northeast, and 19% in the Central-west and South regions. Conclusion: The migratory pattern of the pandemic among KT recipients followed that of the general population and the outcomes were influenced by regional features. COVID-19 in KT recipients was associated with high utilization of health-care resources and higher fatality rates than those reported in the general population.
DOI: 10.6084/m9.figshare.19901601.v1
title: Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study

description: Abstract Introduction: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COVID-19 in KT recipients according to Brazilian geographic regions. Methods: This multicenter national retrospective analysis included data from KT recipients with confirmed COVID-19 between March and November 2020. Results: Thirty-five of the 81 centers (57% of KT activity in Brazil) reported 1,680 patients with COVID-19. The Northeast was the first to reach the peak in the number of infections. The Southeast, due to its population density, contributed with the largest number of patients. Patients had a median age of 52 years, 76% had hypertension and 34% diabetes, 75% were recipients of a deceased donor, and the time interval between diagnosis and transplantation was 5.9 years. In 53% of patients, immunosuppression was adjusted, and clinical support varied according to geographic region. Hospitalization was required for 65% of the patients, 35% of them needed intensive care, 25% mechanical ventilation, and 23% renal replacement therapy. The 90-day overall fatality was 21%, being 23% in the Southeast, 16% in the Northeast, and 19% in the Central-west and South regions. Conclusion: The migratory pattern of the pandemic among KT recipients followed that of the general population and the outcomes were influenced by regional features. COVID-19 in KT recipients was associated with high utilization of health-care resources and higher fatality rates than those reported in the general population.
DOI: 10.6084/m9.figshare.19901613
title: FLIPPED CLASSROOM IN TEACHING ORGANIC CHEMISTRY: A CASE STUDY.

description: The flipped classroom is one of the types of rotation model strategies that aim of increasing interaction and personalized contact time between students and teachers in the classroom setting. In this study, we investigated the application of the flipped classroom strategy in two classes of the different semesters in the discipline of Organic Chemistry. The teacher applied this strategy in different ways in order to verify how the flipped classroom can contribute to the teaching and learning process in the content of Nuclear Magnetic Resonance (NMR). The research, of qualitative nature, is a case study being carried out in six steps with the participation of twenty-five students and one teacher. The instruments used for data collection were an investigative questionnaire (applied to students) and a structured interview (carried out with the teacher). The results show that the students had control over their learning, presenting a favorable position for the application of the strategy. In addition, the teacher reported that it was possible to deepen the content of NMR with his students, teaching the class in a different way than he was used to, focusing on doubts (individual and collective), as well as comments regarding the materials produced by him.
DOI: 10.6084/m9.figshare.19901613.v1
title: FLIPPED CLASSROOM IN TEACHING ORGANIC CHEMISTRY: A CASE STUDY.

description: The flipped classroom is one of the types of rotation model strategies that aim of increasing interaction and personalized contact time between students and teachers in the classroom setting. In this study, we investigated the application of the flipped classroom strategy in two classes of the different semesters in the discipline of Organic Chemistry. The teacher applied this strategy in different ways in order to verify how the flipped classroom can contribute to the teaching and learning process in the content of Nuclear Magnetic Resonance (NMR). The research, of qualitative nature, is a case study being carried out in six steps with the participation of twenty-five students and one teacher. The instruments used for data collection were an investigative questionnaire (applied to students) and a structured interview (carried out with the teacher). The results show that the students had control over their learning, presenting a favorable position for the application of the strategy. In addition, the teacher reported that it was possible to deepen the content of NMR with his students, teaching the class in a different way than he was used to, focusing on doubts (individual and collective), as well as comments regarding the materials produced by him.
DOI: 10.6084/m9.figshare.19901637
title: PREPARATION OF HYBRID POLYMERS AND USE AS CONTROLLED RELEASE DELIVERY VEHICLE FOR VOLATILE REPELLENT TO CONTROL Aedes aegypti

description: The Zika virus is a flavivirus spread by the Aedes aegypti mosquito, which also transmits dengue and chikungunya. Current forms of control include elimination of mosquito breeding sites, use of insecticides, repellents and other means. The present study developed new adsorbent materials based on silica and biomaterials capable of releasing an Aedes aegypti mosquito repellent. The materials synthesized were characterized by Fourier-Transform Infrared, thermogravimetric analysis, Scanning Electron Microscopy and Brunauer, Emmett and Teller analysis and tested with citronella, an essential oil widely recognized as a natural insect repellent. The materials presented type IV isotherms, with type H1 hysteresis, characteristic of mesoporous materials, with pore diameters of between 50 Å and 80 Å. Materials based on silica-chitosan-glutaraldehyde dried in an oven (SCGO) and silica-chitosan-glutaraldehyde dried under a vacuum (SCGV) were found to produce more controlled release of citronella essential oil. The bioassay test was performed using a horizontal double-choice olfactometer. The adsorbent SCGO remained stable for the four hours of the bioassay, while the commercial repellent became ineffective after two hours of release. The production of a prototype in the form of bracelets, stickers releasing a volatile repellent is therefore proposed as a method for the control of the mosquito in urban areas.
DOI: 10.6084/m9.figshare.19901637.v1
title: PREPARATION OF HYBRID POLYMERS AND USE AS CONTROLLED RELEASE DELIVERY VEHICLE FOR VOLATILE REPELLENT TO CONTROL Aedes aegypti

description: The Zika virus is a flavivirus spread by the Aedes aegypti mosquito, which also transmits dengue and chikungunya. Current forms of control include elimination of mosquito breeding sites, use of insecticides, repellents and other means. The present study developed new adsorbent materials based on silica and biomaterials capable of releasing an Aedes aegypti mosquito repellent. The materials synthesized were characterized by Fourier-Transform Infrared, thermogravimetric analysis, Scanning Electron Microscopy and Brunauer, Emmett and Teller analysis and tested with citronella, an essential oil widely recognized as a natural insect repellent. The materials presented type IV isotherms, with type H1 hysteresis, characteristic of mesoporous materials, with pore diameters of between 50 Å and 80 Å. Materials based on silica-chitosan-glutaraldehyde dried in an oven (SCGO) and silica-chitosan-glutaraldehyde dried under a vacuum (SCGV) were found to produce more controlled release of citronella essential oil. The bioassay test was performed using a horizontal double-choice olfactometer. The adsorbent SCGO remained stable for the four hours of the bioassay, while the commercial repellent became ineffective after two hours of release. The production of a prototype in the form of bracelets, stickers releasing a volatile repellent is therefore proposed as a method for the control of the mosquito in urban areas.
DOI: 10.6084/m9.figshare.19901661
title: Methanolic Extract of Rhinella marina Poison: Chemical Composition, Antioxidant and Immunomodulatory Activities

description: This study investigated the chemical composition, immunomodulatory and antioxidant activities, and histopathological analysis of mice tissues treated with methanolic extract from R. marina poison. Marinobufagin, telecinobufagin and bufalin were identified in the chemical profile. The biochemical results demonstrated an effect between doses in the period of 7 days, an immunomodulatory effect was observed regarding the production capacity of interleukin (IL)-12p70 and tumor necrosis factor (TNF)-α at 7 and 30 days, respectively. The lower dose suggests better bioactivity to the treated animal than the higher dose. Histopathological analyses of the lung, heart, kidney and liver showed tissue damage in all organs, mainly in the lung, and were proportional to the dose and the treatment period. We observed that the treatment modulated cytokine production, and therefore this effect may be related to the tissue damage observed. This study demonstrates a positive effect in the antioxidant and immune system, indicating that the molecules found in the extract have biotechnological potential.
DOI: 10.6084/m9.figshare.19901661.v1
title: Methanolic Extract of Rhinella marina Poison: Chemical Composition, Antioxidant and Immunomodulatory Activities

description: This study investigated the chemical composition, immunomodulatory and antioxidant activities, and histopathological analysis of mice tissues treated with methanolic extract from R. marina poison. Marinobufagin, telecinobufagin and bufalin were identified in the chemical profile. The biochemical results demonstrated an effect between doses in the period of 7 days, an immunomodulatory effect was observed regarding the production capacity of interleukin (IL)-12p70 and tumor necrosis factor (TNF)-α at 7 and 30 days, respectively. The lower dose suggests better bioactivity to the treated animal than the higher dose. Histopathological analyses of the lung, heart, kidney and liver showed tissue damage in all organs, mainly in the lung, and were proportional to the dose and the treatment period. We observed that the treatment modulated cytokine production, and therefore this effect may be related to the tissue damage observed. This study demonstrates a positive effect in the antioxidant and immune system, indicating that the molecules found in the extract have biotechnological potential.
DOI: 10.6084/m9.figshare.19901670
title: Absolute Configuration Reassignment of Natural Products: An Overview of the Last Decade

description: The assignment of absolute configuration (AC) is a crucial step in the structural characterization of natural products, especially for those subjected to biological assays. Methods such as X-ray crystallography, stereocontrolled organic synthesis, nuclear magnetic resonance (NMR), and chiroptical spectroscopies are commonly used to determine the AC of chiral natural compounds. Even with these well-established techniques, however, unambiguous stereochemical assignments of natural products remain a challenge, resulting in an increasing number of structural misassignments being reported every year. Herein, we will present the main techniques that have been used in AC reassignments of natural products over the last 10 years, along with some selected examples. Special attention will be paid to the strengths and weaknesses of each approach. With this, we expect to provide the readers with critical information to help them to choose the appropriate methods for correct AC determinations.
DOI: 10.6084/m9.figshare.19901670.v1
title: Absolute Configuration Reassignment of Natural Products: An Overview of the Last Decade

description: The assignment of absolute configuration (AC) is a crucial step in the structural characterization of natural products, especially for those subjected to biological assays. Methods such as X-ray crystallography, stereocontrolled organic synthesis, nuclear magnetic resonance (NMR), and chiroptical spectroscopies are commonly used to determine the AC of chiral natural compounds. Even with these well-established techniques, however, unambiguous stereochemical assignments of natural products remain a challenge, resulting in an increasing number of structural misassignments being reported every year. Herein, we will present the main techniques that have been used in AC reassignments of natural products over the last 10 years, along with some selected examples. Special attention will be paid to the strengths and weaknesses of each approach. With this, we expect to provide the readers with critical information to help them to choose the appropriate methods for correct AC determinations.
DOI: 10.6084/m9.figshare.19901682
title: Pelvic floor dysfunction in primiparous women up to 6 months after delivery: cohort study

description: ABSTRACT Objective: To analyze pelvic floor muscular strength (PFMS), urinary (UI) and anal (AI) incontinence and dyspareunia in primiparous women up to 6 months after normal or cesarean delivery. Methods: this is a prospective cohort with 169 women (128 normal births, 41 cesarean sections), followed between 50-70 and 170-190 days postpartum, when PFMS was measured using perineometry, and UI and AI and dyspareunia, through interview. Results: PFMS, UI and dyspareunia were similar between types of delivery. The difference was significant only for the time elapsed, with improvement in the studied period (2 and 6 months postpartum). Regarding AI, there was a significant difference between 2 and 6 months postpartum, with an interaction between type of delivery and time (p=0.022). Conclusion: the type of delivery did not show any influence on pelvic floor dysfunctions, except for AI. For all outcomes, there was an improvement in the period studied.
DOI: 10.6084/m9.figshare.19901682.v1
title: Pelvic floor dysfunction in primiparous women up to 6 months after delivery: cohort study

description: ABSTRACT Objective: To analyze pelvic floor muscular strength (PFMS), urinary (UI) and anal (AI) incontinence and dyspareunia in primiparous women up to 6 months after normal or cesarean delivery. Methods: this is a prospective cohort with 169 women (128 normal births, 41 cesarean sections), followed between 50-70 and 170-190 days postpartum, when PFMS was measured using perineometry, and UI and AI and dyspareunia, through interview. Results: PFMS, UI and dyspareunia were similar between types of delivery. The difference was significant only for the time elapsed, with improvement in the studied period (2 and 6 months postpartum). Regarding AI, there was a significant difference between 2 and 6 months postpartum, with an interaction between type of delivery and time (p=0.022). Conclusion: the type of delivery did not show any influence on pelvic floor dysfunctions, except for AI. For all outcomes, there was an improvement in the period studied.
DOI: 10.6084/m9.figshare.19901691
title: The Resource-Seeking Internationalization Process of a Nongovernmental Organization

description: ABSTRACT This paper aims at investigating the resource-seeking internationalization process of an international nongovernmental organization (INGO) from the process point of view. INGOs have received scant attention in the international business literature, despite their relevance in almost every aspect of aid and development and as actors of global governance. The research question addresses the issue of whether or not INGOs can follow a path similar to business firms in their internationalization process. The study departs from two different theoretical perspectives - the Uppsala model and the born global perspective - to study the case of the NGO Médecins Sans Frontières (Doctors Without Borders), an international, private, nonprofit, member-based organization. We identify three stages in the resource-seeking internationalization process of the NGO, which present similarities with that of business organizations. The study contributes to the IB literature by revealing key aspects of the internationalization trajectory of an NGO to raise funds and recruit volunteers in advanced and emerging economies with the purpose of employing these resources to support its emergency assistance activities in less developed countries, and to the literature on INGOs in exploring the issue of resource-seeking internationalization.
DOI: 10.6084/m9.figshare.19901691.v1
title: The Resource-Seeking Internationalization Process of a Nongovernmental Organization

description: ABSTRACT This paper aims at investigating the resource-seeking internationalization process of an international nongovernmental organization (INGO) from the process point of view. INGOs have received scant attention in the international business literature, despite their relevance in almost every aspect of aid and development and as actors of global governance. The research question addresses the issue of whether or not INGOs can follow a path similar to business firms in their internationalization process. The study departs from two different theoretical perspectives - the Uppsala model and the born global perspective - to study the case of the NGO Médecins Sans Frontières (Doctors Without Borders), an international, private, nonprofit, member-based organization. We identify three stages in the resource-seeking internationalization process of the NGO, which present similarities with that of business organizations. The study contributes to the IB literature by revealing key aspects of the internationalization trajectory of an NGO to raise funds and recruit volunteers in advanced and emerging economies with the purpose of employing these resources to support its emergency assistance activities in less developed countries, and to the literature on INGOs in exploring the issue of resource-seeking internationalization.
DOI: 10.6084/m9.figshare.19360955
title: COVID-19 and Placement Impact on College Students

description: The research goal was to investigate the impact of mindfulness-based training on stress and self-esteem of college students involved in placements. One hundred college students participating in campus placements were selected using purposive sampling from a Amrita School of Engineering, Coimbatore, India. College students were administered with Perceived Stress Scale, Rosenberg Self-Esteem Scale, and Kuppuswamy Socio-Economic Scale.
DOI: 10.6084/m9.figshare.19360955.v4
title: COVID-19 and Placement Impact on College Students

description: The research goal was to investigate the impact of mindfulness-based training on stress and self-esteem of college students involved in placements. One hundred college students participating in campus placements were selected using purposive sampling from a Amrita School of Engineering, Coimbatore, India. College students were administered with Perceived Stress Scale, Rosenberg Self-Esteem Scale, and Kuppuswamy Socio-Economic Scale.