cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5098201.v1
title: Repeated annual influenza vaccination and vaccine effectiveness: review of evidence

description: <b>Introduction</b>: Studies in the 1970s and 1980s signaled concern that repeated influenza vaccination could affect vaccine protection. The antigenic distance hypothesis provided a theoretical framework to explain variability in repeat vaccination effects based on antigenic similarity between successive vaccine components and the epidemic strain. <b>Areas covered</b>: A meta-analysis of vaccine effectiveness studies from 2010–11 through 2014–15 shows substantial heterogeneity in repeat vaccination effects within and between seasons and subtypes. When negative effects were observed, they were most pronounced for H3N2, especially in 2014–15 when vaccine components were unchanged and antigenically distinct from the epidemic strain. Studies of repeated vaccination across multiple seasons suggest that vaccine effectiveness may be influenced by more than one prior season. In immunogenicity studies, repeated vaccination blunts the hemagglutinin antibody response, particularly for H3N2. <b>Expert commentary</b>: Substantial heterogeneity in repeated vaccination effects is not surprising given the variation in study populations and seasons, and the variable effects of antigenic distance and immunological landscape in different age groups and populations. Caution is required in the interpretation of pooled results across multiple seasons, since this can mask important variation in repeat vaccination effects between seasons. Multi-season clinical studies are needed to understand repeat vaccination effects and guide recommendations.
DOI: 10.6084/m9.figshare.5097883.v1
title: Management of allergic rhinitis in the era of effective over-the-counter treatments

description: Allergic rhinitis (AR) may be regarded as a trivial issue unworthy of the doctor’s time, and with the availability of many different over-the-counter (OTC) treatments, up to two thirds of patients self-manage AR before seeking medical care. Yet, AR can have a significant impact on health-related quality of life and is associated with a greater detriment to work productivity than other chronic diseases such as diabetes and hypertension. For many patients, the impact on quality of life is greater than suggested by reported symptoms and should also be a focus of treatment. Although many patients can effectively manage AR symptoms independently, a significant percentage will need direction from a physician to obtain optimal results. The availability of several different classes of treatment – including decongestants, sedating and non-sedating antihistamines, and more recently intranasal corticosteroids (INS) – has increased the complexity of self-management, leaving patients confused about the best approach to treatment. Treatment guidelines universally classify INS as the most effective medical agents available for use in the OTC and primary care settings. Many patients are unaware that INS are available OTC and that they are more effective than other therapies. Patients may have negative perceptions about the safety of INS and may have experienced unpleasant taste, scent, and feel with nasal sprays. Unless a patient volunteers the information, healthcare professionals (HCPs) may be unaware that the patient has significant AR and is using one or more OTC AR therapies. To address this gap in communication, HCPs must be proactive in identifying, assessing, and advising patients with AR, including best strategies to assess allergen trigger symptoms, which treatments are appropriate, and when and how to use them. Proper use of delivery devices is especially important. This article reviews the primary care management of AR in the context of the availability of effective OTC medicines.
DOI: 10.6084/m9.figshare.5097880.v1
title: Spinal racemose cysticercosis: case report and review

description: Cysticercosis is a common helminthic infection worldwide, endemic in Central and South America, sub-Saharan Africa, and Southeast Asia. Neurocysticercosis typically involves brain parenchyma, subarachnoid space, and the ventricular system. Although the spinal cord is frequently involved in patients with parenchymal neurocysticercosis, isolated spinal involvement is rare, occurring in only 1–3% of patients. We report a case of racemose spinal neurocysticercosis with brain parenchyma involvement in a 49-year-old Mexican man, who presented with unsteady gait and bilateral arm numbness and weakness. Magnetic resonance imaging revealed multiseptated cystic lesions in the upper cervical spinal canal and nonenhancing intradural extramedullary cystic lesions in the thoracic spine. The patient underwent sub-occipital craniectomy with decompression, followed by a course of steroids and albendazole. Pathology confirmed the diagnosis of neurocysticercosis, and the patient’s symptoms resolved after treatment. We include discussion on the symptoms, diagnosis, and treatment of neurocysticercosis with a focus on the spinal form.
DOI: 10.6084/m9.figshare.5097847
title: Variance stable normalisation for Illumina targeted NGS

description: Raw Log2 ratios output of CNVkit. Three datasets are provided. Each one contains the full set of samples normalised against one of three clusters of normal samples identified using a model based clustering.<br>
DOI: 10.6084/m9.figshare.5097847.v1
title: Variance stable normalisation for Illumina targeted NGS

description: Raw Log2 ratios output of CNVkit. Three datasets are provided. Each one contains the full set of samples normalised against one of three clusters of normal samples identified using a model based clustering.<br>
DOI: 10.6084/m9.figshare.5097841
title: Time dependency of copy number aberrations and dating of cancer phylogenies

description: Supplementary Data S8: Segmented Log2 ratios and integer level CNA for the 52 metastatic lobular breast cancer patients<br><br><br>Note:<br>All data are distributed as R workspaces, one for each sample. Each workspace further contains a data frame which is the output of the least square regression PCF segmentation with additional columns appended for convenience
DOI: 10.6084/m9.figshare.5097841.v1
title: Time dependency of copy number aberrations and dating of cancer phylogenies

description: Supplementary Data S8: Segmented Log2 ratios and integer level CNA for the 52 metastatic lobular breast cancer patients<br><br><br>Note:<br>All data are distributed as R workspaces, one for each sample. Each workspace further contains a data frame which is the output of the least square regression PCF segmentation with additional columns appended for convenience
DOI: 10.6084/m9.figshare.5097835
title: Spatial and temporal evolution during metastatic progression

description: Supplementary Data S6: Table detailing all putative somatic mutation calls for the 10 autopsied breast cancer patients<br><br>Supplementary Data S7: Table detailing integer level CNA for the 10 autopsied breast cancer patients<br>
DOI: 10.6084/m9.figshare.5097877.v3
title: Ni work

description: Nickel supported on η-Al<sub>2</sub>O<sub>3</sub> and ZSM-5(80) catalysts with and without the addition of ceria-zirconia, were prepared by co-precipitation and wet impregnation methods and used for the low temperature catalytic partial oxidation of methane (CPOM). The catalysts were tested under reaction temperatures of between 400 and 700 °C with a WHSV of 63,000 mL g<sup>-1</sup> h<sup>-1</sup>. The activity of the catalyst was found to be dependent on the support and preparation method. The optimum catalyst composition of those tested was 10% Ni on 25ÎO<sub>2</sub>-ZrO<sub>2</sub>/ZSM-5(80), prepared by co-precipitation, where the reaction reached equilibrium conversion at 400 °C (T<sub>50% </sub>&lt; 400 °C), which is one of the lowest temperatures reported to date. Further increases in temperature led to improved selectivity to CO reaching 60% at 600 °C. Although the observed kinetics were found to be controlled by strong adsorption of CO at lower temperature, this was an equilibrium limitation with longer time on stream experiments showing no decrease in the catalyst activity over 25 hours at 400 °C.
DOI: 10.6084/m9.figshare.5097745
title: Historical Proliferation Database

description: Data set and associated analysis tools used to correlate various geopolitical factors to the historical decisions of states to pursue or acquire nuclear weapons.
DOI: 10.6084/m9.figshare.5097727
title: Basal hippopotamines from the upper Miocene of Chorora, Ethiopia

description: The Hippopotamidae have been a major component of the African wetland fauna for the last 7 million years, following the ‘Hippopotamine Event,’ i.e., the sudden emergence in the fossil record of the subfamily Hippopotaminae, including both extant species. The general dearth of African fossiliferous deposits dated between 9.5 Ma and 7.5 Ma concealed until now the evolution that led to the Hippopotamine Event and the subsequent success of these large semiaquatic herbivores. Part of this evolution is unveiled by the hippopotamid dental remains found at Chorora, a late Miocene site of the southern Afar Depression in Ethiopia spanning most of the fossil-depleted time interval. Although fragmentary, these remains represent a new, mid-sized hippopotamid species dated to ca. 8 Ma, as well as a somewhat younger, larger form. A cladistic analysis of a large array of cetartiodactyls indicates that the Chorora taxa were basal to the latest Miocene hippopotamines. The new species displays a mosaic of dental characters that support the attribution of the new species to a new genus within Hippopotaminae. The new fossils also clarify the course of early hippopotamine dental evolution. The Chorora hippopotamids suggest that transition to a marked abundance of hippopotamines with their unique dental pattern in African ecosystems occurred within a relatively short time interval, most probably between 8 Ma and 7.5 Ma. http://zoobank.org/urn:lsid:zoobank.org:pub:47B9381F-E3B5-40C9-B9AB-51CC3D0D3A8A SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Boisserie, J.-R., G. Suwa, B. Asfaw, F. Lihoreau, R. L. Bernor, S. Katoh, and Y. Beyene. 2017. Basal hippopotamines from the upper Miocene of Chorora, Ethiopia. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2017.1297718.
DOI: 10.6084/m9.figshare.5097727.v1
title: Basal hippopotamines from the upper Miocene of Chorora, Ethiopia

description: The Hippopotamidae have been a major component of the African wetland fauna for the last 7 million years, following the ‘Hippopotamine Event,’ i.e., the sudden emergence in the fossil record of the subfamily Hippopotaminae, including both extant species. The general dearth of African fossiliferous deposits dated between 9.5 Ma and 7.5 Ma concealed until now the evolution that led to the Hippopotamine Event and the subsequent success of these large semiaquatic herbivores. Part of this evolution is unveiled by the hippopotamid dental remains found at Chorora, a late Miocene site of the southern Afar Depression in Ethiopia spanning most of the fossil-depleted time interval. Although fragmentary, these remains represent a new, mid-sized hippopotamid species dated to ca. 8 Ma, as well as a somewhat younger, larger form. A cladistic analysis of a large array of cetartiodactyls indicates that the Chorora taxa were basal to the latest Miocene hippopotamines. The new species displays a mosaic of dental characters that support the attribution of the new species to a new genus within Hippopotaminae. The new fossils also clarify the course of early hippopotamine dental evolution. The Chorora hippopotamids suggest that transition to a marked abundance of hippopotamines with their unique dental pattern in African ecosystems occurred within a relatively short time interval, most probably between 8 Ma and 7.5 Ma. http://zoobank.org/urn:lsid:zoobank.org:pub:47B9381F-E3B5-40C9-B9AB-51CC3D0D3A8A SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP Citation for this article: Boisserie, J.-R., G. Suwa, B. Asfaw, F. Lihoreau, R. L. Bernor, S. Katoh, and Y. Beyene. 2017. Basal hippopotamines from the upper Miocene of Chorora, Ethiopia. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2017.1297718.
DOI: 10.6084/m9.figshare.5097697
title: Abortion and social support.dta

description: Cross-sectional study conducted in three maternal health centers (Ollantay, Manuel Barreto and Daniel Alcides Carrion) located in Southern Lima, part of the Directorate of Health II, in Peru. Potential participants were women aged between 18 and 25 years, attended in at least one of the three aforementioned maternal health centers between March and May 2013. Study subjects were selected in consecutive order after verifying selection criteria. Illiterate women were excluded as the questionnaire was self-applied.<br>
DOI: 10.17028/rd.lboro.5097592
title: Experimental dataset, frequency response curves for automotive vehicle variability studies. Measurements on several identical vehicles using a force hammer as excitation and accelerometer to obtain the response.

description: Experimental frequency response function measurements (excitation by impact hammer and response at an accelerometer) on many identical automotive vehicles.<br>Saved as Matlab Mat files, this archive contains individually labelled files with point mobility data for 1, or 16 vehicles, transfer mobility data for 1, or 16 vehicles and coherence data for 1, 16 vehicles.A separate frequency axis is given in a separate file. Loading the frequency and one of the data files is enough to replicate the results in the journal paper. Example plotting routine of Transfer mobility for Engine Mount to lower A pillar on 1 vehicle repeated 30 times is given as a file.Raw data files are available separately on request.
DOI: 10.6084/m9.figshare.5097502
title: New draft item

description: test
DOI: 10.6084/m9.figshare.5097502.v2
title: New draft item

description: test
DOI: 10.6084/m9.figshare.5097502.v1
title: New draft item

description: test
DOI: 10.6084/m9.figshare.5097403
title: Advance planning in spoken and written sentence production

description: Analysis scripts and data<br>
DOI: 10.6084/m9.figshare.5097403.v2
title: Advanced planning in spoken and written sentence production

description: Analysis scripts and data<br>
DOI: 10.6084/m9.figshare.5097403.v1
title: Analysis

description: Analysis scripts and data<br>
DOI: 10.6084/m9.figshare.5097352
title: “Not always a straight path”: patients’ perspectives following anterior cruciate ligament rupture and reconstruction

description: <b>Purpose:</b> To explore patients’ perspectives following anterior cruciate ligament rupture and subsequent reconstructive surgery. <b>Methods:</b> A qualitative study design was employed, using validated questionnaires, interviews and general inductive methodology. Semi-structured interviews were conducted with five men and four women who had undergone an anterior cruciate ligament reconstruction in the past 6–36 months. Participants completed the Knee Osteoarthritis Outcome Score and the Tegner Activity Score. Descriptive statistics were used to analyze quantitative data. Interviews were recorded, transcribed and analyzed using the general inductive approach to develop key themes. <b>Results:</b> Participants had not returned to pre-injury knee-related activity levels (Tegner score: 7 pre-injury; 4 current). The theme of a disruptive “journey” emerged with two sub-themes of “loss of identity” and “life at the present,” influenced positively and negatively by “support systems” and experience with the “care pathway.” This unequivocally negative experience resulted in irrevocable changes to their lives, reflected by current lower knee-related quality of life. <b>Conclusions:</b> Anterior cruciate ligament injury and rehabilitation thereof have a profound influence in the individual’s identity. The results imply that a broader approach is needed within the rehabilitation process to address psychosocial factors, in addition to physical impairments and function.Implications for rehabilitationAnterior cruciate ligament rupture has a profound influence on patients’ understanding of their individual identity.Support systems the patients have in place influence the patients’ experience of the care pathway.Understanding psychosocial responses and implementing appropriate strategies and interventions for these may be critical for rehabilitation of these patients. Anterior cruciate ligament rupture has a profound influence on patients’ understanding of their individual identity. Support systems the patients have in place influence the patients’ experience of the care pathway. Understanding psychosocial responses and implementing appropriate strategies and interventions for these may be critical for rehabilitation of these patients.
DOI: 10.6084/m9.figshare.5097352.v1
title: “Not always a straight path”: patients’ perspectives following anterior cruciate ligament rupture and reconstruction

description: <b>Purpose:</b> To explore patients’ perspectives following anterior cruciate ligament rupture and subsequent reconstructive surgery. <b>Methods:</b> A qualitative study design was employed, using validated questionnaires, interviews and general inductive methodology. Semi-structured interviews were conducted with five men and four women who had undergone an anterior cruciate ligament reconstruction in the past 6–36 months. Participants completed the Knee Osteoarthritis Outcome Score and the Tegner Activity Score. Descriptive statistics were used to analyze quantitative data. Interviews were recorded, transcribed and analyzed using the general inductive approach to develop key themes. <b>Results:</b> Participants had not returned to pre-injury knee-related activity levels (Tegner score: 7 pre-injury; 4 current). The theme of a disruptive “journey” emerged with two sub-themes of “loss of identity” and “life at the present,” influenced positively and negatively by “support systems” and experience with the “care pathway.” This unequivocally negative experience resulted in irrevocable changes to their lives, reflected by current lower knee-related quality of life. <b>Conclusions:</b> Anterior cruciate ligament injury and rehabilitation thereof have a profound influence in the individual’s identity. The results imply that a broader approach is needed within the rehabilitation process to address psychosocial factors, in addition to physical impairments and function.Implications for rehabilitationAnterior cruciate ligament rupture has a profound influence on patients’ understanding of their individual identity.Support systems the patients have in place influence the patients’ experience of the care pathway.Understanding psychosocial responses and implementing appropriate strategies and interventions for these may be critical for rehabilitation of these patients. Anterior cruciate ligament rupture has a profound influence on patients’ understanding of their individual identity. Support systems the patients have in place influence the patients’ experience of the care pathway. Understanding psychosocial responses and implementing appropriate strategies and interventions for these may be critical for rehabilitation of these patients.
DOI: 10.6084/m9.figshare.5097328
title: O PROCESSO DE DESCOLONIZAÇÃO BOLIVIANO, AO NÍVEL DE ACESSO AO ENSINO SUPERIOR.

description: Os novos modelos de educação superior têm por finalidade reparar as injustiças históricas em relação aos grupos sociais excluídos e marginalizados pelos processos de colonização e neocolonização. Com base nesse cenário, propõe-se nesse projeto uma análise dos documentos institucionais da Universidad Andina Simón Bolívar (UASB), visando encontrar nesses documentos, indícios de adoção de novas formas de conhecimento e novas formas de autonomia do processo de geração do conhecimento cientifico local. Justifica-se, pela necessidade de estabelecer uma análise em torno dos processos de redemocratização dos países da América Latina, e assim retratar uma nova perspectiva social de natureza educativa. Este projeto é parte integrante do programa de Iniciação Científica da Universidade Nove de Julho, vinculado à pesquisa mais ampla intitulada “Fundamentos e horizontes epistemológicos dos processos de internacionalização e inclusão da diversidade cultural e epistemológica ao nível da educação superior no Brasil e outros países da América Latina: Argentina, Brasil, Bolívia, Equador e Venezuela.”<br><br>
DOI: 10.6084/m9.figshare.5097322
title: Supplementary Material for: Outcomes in Melanoma Patients Treated with BRAF/MEK-Directed Therapy or Immune Checkpoint Inhibition Stratified by Clinical Trial versus Standard of Care

description: <b><i>Objectives:</i></b> Since 2011, metastatic melanoma treatment has evolved with commercial approval of BRAF- and MEK-targeted therapy and CTLA-4- and PD-1-blocking antibodies (immune checkpoint inhibitors, ICI). While novel therapies have demonstrated improved prognosis in clinical trials, few studies have examined the evolution of prognosis and toxicity of these drugs among an unselected population. We assess whether survival and toxicity reported in trials, which typically exclude most patients with brain metastases and poor performance status, are recapitulated within a commercial access population. <b><i>Methods:</i></b> 182 patients diagnosed with stage IV melanoma from July 2006 to December 2013 and treated with BRAF- and/or MEK-targeted therapy or ICI were prospectively studied. Outcomes and clinicopathologic differences between trial and commercial cohorts were assessed. <b><i>Results:</i></b> Patients receiving commercial therapy (vs. on trial) had poorer prognostic features (i.e., brain metastases) and lower median overall survival (mOS) when assessed across all treatments (9.2 vs. 17.5 months, <i>p</i> = 0.0027). While toxicity within trial and commercial cohorts did not differ, patients who experienced toxicity had increased mOS (<i>p</i> &lt; 0.001), irrespective of stratification by trial status or therapy. <b><i>Conclusion</i></b>: Metastatic melanoma patients receiving commercial treatment may represent a different clinical population with poor prognostic features compared to trial patients. Toxicity may prognosticate treatment benefit.