DOI: 10.3886/icpsr39158
title: Transportability of Adolescent Sexual Risk Prevention Interventions, United States, 2000-2015
title: Archival Version

description: The cost and challenge of running clinical trials in each subpopulation and each setting results in a patchwork of evidence. Often, some interventions are evaluated with trial samples that are distinct in the distribution of potential treatment modifiers. These gaps in understanding can be filled using transportability methods where the subset of trials that evaluate an intervention are used to transport the potential outcome mean for that intervention to the target population. Despite this, transportability analysis suffers from systematic missing data, a missing data problem that is unique to the settings where data comes from multiple sources.
This harmonized dataset was created to evaluate novel transportability methods. It includes data from six trials of adolescent sexual risk prevention. Interventions evaluated include emotion regulation, skills training, family based, and health promotion. Populations studied include adolescents in mental health care (aged 13-18), those in alternative educational placement (aged 12-19), those indicated by school personnel as having mental or behavioral health issues (aged 12-14), and Black and African American adolescents (aged 14-17) that had lived in the urban areas of four major U.S. cities.
description: The purpose of this study is to develop and test methods to transport or generalize results from clinical trials to the target population. Assuming an intervention targeting one of these vulnerabilities will be effective across subpopulations that share the vulnerability, data from these trials enables evaluation of the utility of transportation methods.
description: The research team employed a three-step approach to evaluate the utility of transportation methods:

Created new methods for applying the results of clinical trials with missing data to the larger group of interest.
Tested the new methods on the data that mimic real patient data.
Applied the methods to the six trials of programs for youth at risk for HIV.
description: The data includes variables about:

Psychological treatment
Sexual behavior
Self-efficacy for condom use
Substance abuse
Self-harm
Emotional self-efficacy
HIV knowledge
Peer norms
Impulsive decision making
Parent-child sexual communication
Delinquent behavior
Demographic variables include:

Race
Age
Income
Education
description: The harmonized dataset includes data from six trials focusing on adolescents attending therapeutic schools, undergoing mental health treatment and living with primary caregiver, showing symptoms of emotional or behavior problems or indicate sexual or substance use behavior, and are Black and African American adolescents residing in one of the test cities.
description: Datasets: 
DS0: Study-Level Files
DS1: Public-Use Data
DS2: Restricted-Use Data
description: Adolescents at risk for HIV. Smallest Geographic Unit: City
description: audio computer-assisted self interview (ACASI); paper and pencil interview (PAPI); web-based surveyFor additional information on the Transportability of Adolescent Sexual Risk Prevention Interventions Study, please visit the Brown University Health website.Information on the harmonization process, the subset of trials, and scales can be found in the documentation.