cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4317286
title: Supplementary data for 'Comparison of sparse biclustering algorithms for gene expression datasets'

description: <strong>Motivation:</strong> Gene clustering and sample clustering are commonly used to find patterns in gene expression datasets. However, in heterogeneous samples (e.g. different tissues or disease states), genes may cluster differently. Biclustering algorithms aim to solve this issue by performing sample clustering and gene clustering simultaneously. Existing reviews of biclustering algorithms have yet to include a number of more recent algorithms and have based comparisons on simplistic simulated datasets without specific evaluation of biclusters in real datasets, using less robust metrics. <br> <strong>Results:</strong> In this study we compared four classes of sparse biclustering algorithms on a range of simulated and real datasets. In particular we use a knockout mouse RNA-seq dataset to evaluate each algorithm’s ability to simultaneously cluster genes and cluster samples. We found that Bayesian algorithms with strict sparsity constraints had high accuracy on the simulated datasets and didn't require any post-processing, but were considerably slower than other algorithm classes. We assessed whether non-negative matrix factorisation algorithms can be repurposed for biclustering and found that, although the raw output was poor, after using a sparsity-inducing post-processing procedure we introduce, one such algorithm was one of the most highly ranked on real datasets. We also exhibit the limitations of biclustering algorithms by varying the complexity of simulated datasets. The algorithms generally struggled on simulated datasets with a large number of implanted factors, or with a large number of genes. In real datasets, the algorithms rarely returned clusters containing samples from multiple tissues, which highlights the need for further thought in the design and analysis of multi-tissue studies to avoid differences between tissues dominating the analysis. <br> Code to run the analysis is available at https://github.com/nichollskc/biclust_comp, including wrappers for each algorithm, implementations of evaluation metrics, and code to simulate datasets and perform pre- and post-processing.
DOI: 10.6084/m9.figshare.13366310
title: Dataset for the article "Body stoichiometry of heterotrophs: assessing drivers of interspecific variations in elemental composition"

description: Dataset of stoichiometric traits of heterotrophs<br>
DOI: 10.21258/1624624
title: Inventario forestale nazionale svizzero - Tabella n. 899111
DOI: 10.21258/1578462
title: Inventario forestale nazionale svizzero - Tabella n. 891673
DOI: 10.21258/1569699
title: Inventaire forestier national suisse - Tableau no 899279
DOI: 10.17632/wbkc2cp6sn.1
title: Data for: Interaction and Quadratic Effects in Probit Model with Endogenous Regressors
DOI: 10.21258/1622302
title: Inventario forestale nazionale svizzero - Tabella n. 898209
DOI: 10.21258/1572448
title: Inventaire forestier national suisse - Tableau no 891972
DOI: 10.21258/1587847
title: Inventario forestale nazionale svizzero - Tabella n. 897298
DOI: 10.17632/2z9g2g8j7t.1
title: Data for: Lithospheric mantle density evolution in the eastern North China Craton during the destruction process: Constraints from the equations of state of minerals and the thermal state
DOI: 10.5281/zenodo.4317501
title: Foliar stoichiometry of woody plants worldwide

description: This data includes foliar N, P, K % in DW of mature leaves in woody plants worldwide. It also contains the georeferenced information and specie. It gathers data from 230 published articles, TRY database (http://www.try-db.org/TryWeb/dp.php), ICP forest database (http://icp-forests.net/page/data-requests), Tundra Trait Team and the Catalan Forest Inventory (Gracia et al., 2004).
DOI: 10.5281/zenodo.4317500
title: Foliar stoichiometry of woody plants worldwide

description: This data includes foliar N, P, K % in DW of mature leaves in woody plants worldwide. It also contains the georeferenced information and specie. It gathers data from 230 published articles, TRY database (http://www.try-db.org/TryWeb/dp.php), ICP forest database (http://icp-forests.net/page/data-requests), Tundra Trait Team and the Catalan Forest Inventory (Gracia et al., 2004).
DOI: 10.21258/1595162
title: Inventario forestale nazionale svizzero - Tabella n. 898550
DOI: 10.21258/1530324
title: Inventaire forestier national suisse - Tableau no 897610
DOI: 10.21258/1588827
title: Inventario forestale nazionale svizzero - Tabella n. 891732
DOI: 10.21258/1619713
title: Inventario forestale nazionale svizzero - Tabella n. 899273
DOI: 10.21258/1590278
title: Inventario forestale nazionale svizzero - Tabella n. 898766
DOI: 10.21258/1540587
title: Inventaire forestier national suisse - Tableau no 892027
DOI: 10.21258/1616270
title: Inventario forestale nazionale svizzero - Tabella n. 899345
DOI: 10.5281/zenodo.4317516
title: Display a simulation of a batch or fed-batch cultivation of S. cerevisiae

description: The model is implemented as it is described in the paper "Pham, Larsson, Enfors - 1998 - Growth and energy metabolism in aerobic fed-batch cultures of Saccharomyces cerevisiae Simulation and mod".<br> The batch and fed-batch are both implemented, the oscillation function was not used.<br> All parameters were taken from the paper and are saved under parameters.py.
DOI: 10.5281/zenodo.4317515
title: Display a simulation of a batch or fed-batch cultivation of S. cerevisiae

description: The model is implemented as it is described in the paper "Pham, Larsson, Enfors - 1998 - Growth and energy metabolism in aerobic fed-batch cultures of Saccharomyces cerevisiae Simulation and mod".<br> The batch and fed-batch are both implemented, the oscillation function was not used.<br> All parameters were taken from the paper and are saved under parameters.py.
DOI: 10.21258/1596846
title: Inventario forestale nazionale svizzero - Tabella n. 902048
DOI: 10.21258/1617175
title: Inventario forestale nazionale svizzero - Tabella n. 898139
DOI: 10.21258/1556235
title: Inventaire forestier national suisse - Tableau no 899624
DOI: 10.21258/1566950
title: Inventaire forestier national suisse - Tableau no 899322
DOI: 10.21258/1540061
title: Inventaire forestier national suisse - Tableau no 898586
DOI: 10.21258/1542445
title: Inventaire forestier national suisse - Tableau no 891929
DOI: 10.21258/1532299
title: Inventaire forestier national suisse - Tableau no 899149
DOI: 10.21258/1588065
title: Inventario forestale nazionale svizzero - Tabella n. 897632
DOI: 10.15454/updpdt/n3vcaj
title: pytest.ini

description: :unav
DOI: 10.15454/updpdt/hcccp7
title: modules.rst

description: :unav
DOI: 10.15454/updpdt/2zsgd1
title: __init__.py

description: :unav
DOI: 10.15454/updpdt/dmdwbp
title: eldam_comparison_with_difference.png

description: :unav
DOI: 10.15454/updpdt/wtpxt5
title: simapro2excel.svg

description: :unav
DOI: 10.15454/updpdt/twj1ol
title: elda_b.xlsm

description: :unav
DOI: 10.15454/updpdt/2rpc92
title: elda_to_simapro.py

description: :unav
DOI: 10.21258/1563564
title: Inventaire forestier national suisse - Tableau no 891916
DOI: 10.15454/updpdt/0jvzfo
title: comparing-simapro-export-with-elda.rst

description: :unav
DOI: 10.15454/updpdt/sthfio
title: test_write_elda.py

description: :unav
DOI: 10.15454/updpdt/wnhemh
title: continue.svg

description: :unav
DOI: 10.15454/updpdt/qi6qza
title: VBA_project_warning.png

description: :unav
DOI: 10.15454/updpdt/cru6nb
title: Capture.PNG

description: :unav
DOI: 10.15454/updpdt/khmjul
title: documentation.rst

description: :unav
DOI: 10.15454/updpdt/prwltj
title: libcrypto-1_1.dll

description: :unav
DOI: 10.15454/updpdt/roxqwi
title: xlsx_a_exported_from_edition_window.XLSX

description: :unav
DOI: 10.15454/updpdt/vd8knl
title: base_widgets.py

description: :unav
DOI: 10.15454/updpdt/vvvsyj
title: __init__.py

description: :unav
DOI: 10.15454/updpdt/sc9eil
title: elda_b.xlsm

description: :unav
DOI: 10.15454/updpdt/d1foz4
title: elda_c_minor.xlsm

description: :unav
DOI: 10.21258/1549631
title: Inventaire forestier national suisse - Tableau no 898582
DOI: 10.15454/updpdt/f5xnmu
title: elda_r.xlsm

description: :unav
DOI: 10.15454/updpdt/9ovcjl
title: elda_d.xlsm

description: :unav
DOI: 10.15454/updpdt/degx7k
title: compare_simapro_export_with_elda.py

description: :unav
DOI: 10.21258/1541700
title: Inventaire forestier national suisse - Tableau no 891733
DOI: 10.15454/updpdt/ulcdyp
title: generate_elda_index.svg

description: :unav
DOI: 10.15454/updpdt/xd6fv3
title: flow-type-highlighted-in-red.rst

description: :unav
DOI: 10.15454/updpdt/pliunp
title: reading_from_xlsx.rst

description: :unav
DOI: 10.15454/updpdt/vzfiom
title: copy-elda-metadata.rst

description: :unav
DOI: 10.15454/updpdt/4mv04y
title: elda.py

description: :unav
DOI: 10.15454/updpdt/kavgfx
title: testing_parameters.py

description: :unav
DOI: 10.15454/updpdt/etcdkc
title: compare_simapro_export_with_elda.ui

description: :unav
DOI: 10.21258/1611425
title: Inventario forestale nazionale svizzero - Tabella n. 897891
DOI: 10.15454/updpdt/emxmnx
title: eu_occitanie.png

description: :unav
DOI: 10.15454/updpdt/iedawg
title: gui_parameters.py

description: :unav
DOI: 10.15454/updpdt/6f9piv
title: update_elda.png

description: :unav
DOI: 10.15454/updpdt/2mcvdq
title: LICENSE

description: :unav
DOI: 10.15454/updpdt/9mu7ok
title: eldam_copy_metadata.png

description: :unav
DOI: 10.15454/updpdt/7ppc3g
title: eldam_elda_to_simapro_quality_check.png

description: :unav
DOI: 10.15454/updpdt/roajav
title: back.svg

description: :unav
DOI: 10.15454/updpdt/6cvroz
title: about.ui

description: :unav
DOI: 10.15454/updpdt/stjlyd
title: simapro_csv_template.jinja2

description: :unav
DOI: 10.15454/updpdt/tcxrwa
title: eldam_simapro_to_elda_quality_check.png

description: :unav
DOI: 10.15454/updpdt/rvp7bp
title: test_process.py

description: :unav
DOI: 10.15454/updpdt/rjnxo8
title: csv_b.csv

description: :unav
DOI: 10.15454/updpdt/ipulz0
title: simple_comment.jinja2

description: :unav
DOI: 10.15454/updpdt/uxe3ts
title: error-1004-programmatic-access-to-visual-basic-project-is-not-trusted.rst

description: :unav
DOI: 10.15454/updpdt/jtnr6r
title: README.rst

description: :unav
DOI: 10.15454/updpdt/y7ng4w
title: make.bat

description: :unav
DOI: 10.15454/updpdt/jv8wki
title: status_sheet_template_number.png

description: :unav
DOI: 10.15454/updpdt/ysfpsw
title: elda_b.xlsm

description: :unav
DOI: 10.15454/updpdt/nxt2lq
title: simapro.py

description: :unav
DOI: 10.15454/updpdt/4hzufa
title: update_elda_template.ui

description: :unav
DOI: 10.15454/updpdt/nanfwb
title: import_setup.PNG

description: :unav
DOI: 10.15454/updpdt/l5c0oo
title: EldaIndex.xlsx

description: :unav
DOI: 10.15454/updpdt/ivdoeo
title: copy_elda_metadata.png

description: :unav
DOI: 10.15454/updpdt/dq1dlb
title: elda_c_major.xlsm

description: :unav
DOI: 10.34740/kaggle/dsv/1734426
title: US counties COVID 19 dataset
DOI: 10.15454/updpdt/q0bwru
title: input_parameters.png

description: :unav
DOI: 10.15454/updpdt/vo2cxo
title: xlsx_b.XLSX

description: :unav
DOI: 10.15454/updpdt/qr3v0z
title: about.png

description: :unav
DOI: 10.15454/updpdt/hybry1
title: ELDAM.png

description: :unav
DOI: 10.15454/updpdt/h2tg3d
title: eldam.core.rst

description: :unav
DOI: 10.15454/updpdt/hxzcs1
title: version_informations.png

description: :unav
DOI: 10.15454/updpdt/fxukhw
title: copy_elda_metadata.ui

description: :unav
DOI: 10.15454/updpdt/cyuxnq
title: review.rst

description: :unav
DOI: 10.15454/updpdt/v9wuml
title: EldaTemplate.xlsm

description: :unav
DOI: 10.15454/updpdt/9w59op
title: writing_to_elda.rst

description: :unav
DOI: 10.15454/updpdt/wk4mv0
title: update_elda.svg

description: :unav
DOI: 10.15454/updpdt/jiuads
title: requirements.txt

description: :unav
DOI: 10.15454/updpdt/lqaqfa
title: gui_design.rst

description: :unav
DOI: 10.15454/updpdt/vmjlcy
title: elsa.ico

description: :unav
DOI: 10.15454/updpdt/9r50xa
title: elda_a.xlsm

description: :unav
DOI: 10.15454/updpdt/r9lqam
title: SimaPro.png

description: :unav
DOI: 10.15454/updpdt/w0j3bl
title: editing_elda_spreadsheet.rst

description: :unav
DOI: 10.15454/updpdt/60ipr0
title: process_metadata.png

description: :unav
DOI: 10.15454/updpdt/e1m6ql
title: lci_data_format.rst

description: :unav
DOI: 10.15454/updpdt/d1m2kb
title: test_lci_data.py

description: :unav
DOI: 10.15454/updpdt/0bo1tn
title: parameter_conflict_dialog.ui

description: :unav
DOI: 10.15454/updpdt/lxvpo4
title: test_update_elda.py

description: :unav
DOI: 10.15454/updpdt/pgm1da
title: not_an_elda.xlsm

description: :unav
DOI: 10.15454/updpdt/213aaj
title: setup.py

description: :unav
DOI: 10.15454/updpdt/jqsdmo
title: not_an_elda.xlsx

description: :unav
DOI: 10.15454/updpdt/nkhgrq
title: generate_elda_index.ui

description: :unav
DOI: 10.15454/updpdt/lzvh8i
title: test_simapro_xlsx_reader.py

description: :unav
DOI: 10.15454/updpdt/e7levk
title: simapro_import_setup.png

description: :unav
DOI: 10.15454/updpdt/kypyds
title: conf.py

description: :unav
DOI: 10.15454/updpdt/y8rhss
title: exit.svg

description: :unav
DOI: 10.15454/updpdt/9ab0yp
title: test_simapro_csv_writer.py

description: :unav
DOI: 10.15454/updpdt/uukp30
title: mainwindow.py

description: :unav
DOI: 10.15454/updpdt/tv3hxy
title: csv_d.csv

description: :unav
DOI: 10.15454/updpdt/8k92vu
title: test_read_elda.py

description: :unav
DOI: 10.15454/updpdt/uqljfw
title: misc.py

description: :unav
DOI: 10.15454/updpdt/0tfpba
title: process_sheet_with_zones.png

description: :unav
DOI: 10.15454/updpdt/7q4h6u
title: eldam.rst

description: :unav
DOI: 10.15454/updpdt/lpk8rr
title: simapro_to_elda.py

description: :unav
DOI: 10.15454/updpdt/9igrmw
title: compile.bat

description: :unav
DOI: 10.15454/updpdt/xpskng
title: compiling.rst

description: :unav
DOI: 10.15454/updpdt/j8vpjl
title: eldam.gui.rst

description: :unav
DOI: 10.15454/updpdt/hb581h
title: csv_c.csv

description: :unav
DOI: 10.15454/updpdt/qhhiua
title: occitanie.png

description: :unav
DOI: 10.15454/updpdt/nmtdgn
title: dialogs.py

description: :unav
DOI: 10.15454/updpdt/qmwjnn
title: writing_to_csv.rst

description: :unav
DOI: 10.15454/updpdt/bxvfgu
title: eu.png

description: :unav
DOI: 10.15454/updpdt/zhdnry
title: xlsx_a_b.XLSX

description: :unav
DOI: 10.15454/updpdt/6iivcj
title: update-elda-template.rst

description: :unav
DOI: 10.15454/updpdt/3bvo10
title: process_sheet.png

description: :unav
DOI: 10.15454/updpdt/witqwm
title: test_data.py

description: :unav
DOI: 10.15454/updpdt/42tuzq
title: Excel.png

description: :unav
DOI: 10.15454/updpdt/twwllk
title: conftest.py

description: :unav
DOI: 10.15454/updpdt/cy8ctw
title: csv_a_b.csv

description: :unav
DOI: 10.15454/updpdt/vf288x
title: xlsx_e.XLSX

description: :unav
DOI: 10.15454/updpdt/alhrum
title: test_flow.py

description: :unav
DOI: 10.15454/updpdt/2mm5a5
title: bread.XLSX

description: :unav
DOI: 10.15454/updpdt/snbp0m
title: elda_e.xlsm

description: :unav
DOI: 10.15454/updpdt/mwsnso
title: excel2simapro.png

description: :unav
DOI: 10.15454/updpdt/texwzf
title: ELDAM.py

description: :unav
DOI: 10.15454/updpdt/ljggar
title: from-simapro-to-elda.rst

description: :unav
DOI: 10.15454/updpdt/uqtqvu
title: Image ELDAM.pptx

description: :unav
DOI: 10.15454/updpdt/hodw6s
title: exceptions.py

description: :unav
DOI: 10.15454/updpdt/7vzkk2
title: Run-time_error_1004.png

description: :unav
DOI: 10.15454/updpdt/pzl0pv
title: elda_a.xlsm

description: :unav
DOI: 10.15454/updpdt/hubpbv
title: copy_elda_metadata.svg

description: :unav
DOI: 10.15454/updpdt/3bkqna
title: settings.py

description: :unav
DOI: 10.15454/updpdt/xwb3lz
title: eldam_elda_index.png

description: :unav
DOI: 10.15454/updpdt/dua2dy
title: value_to_be_linked.xlsx

description: :unav
DOI: 10.15454/updpdt/wqozcl
title: eldam_comparison_no_difference.png

description: :unav
DOI: 10.15454/updpdt/5yblwo
title: product_type_error_warning1.png

description: :unav
DOI: 10.15454/updpdt/xxfxpx
title: observer.py

description: :unav
DOI: 10.15454/updpdt/bjtam6
title: generate-elda-index.rst

description: :unav
DOI: 10.15454/updpdt/eitsdv
title: conditional_formatting.PNG

description: :unav
DOI: 10.15454/updpdt/jegboh
title: gui.py

description: :unav
DOI: 10.5281/zenodo.4317569
title: Complementary material of the WorkStream 1 of project 4SECURail

description: Deliverables, models, artifacts developed within WP2 of the Shift2Rail project 4SECURAil.
DOI: 10.15454/updpdt/asxi90
title: elda-spreadsheet.rst

description: :unav
DOI: 10.15454/updpdt/wack0w
title: generate_elda_index.py

description: :unav
DOI: 10.15454/updpdt/jd0ho3
title: csv_e.CSV

description: :unav
DOI: 10.15454/updpdt/czjwfp
title: elda_to_simapro.ui

description: :unav
DOI: 10.15454/updpdt/e4hglc
title: eldam.utils.rst

description: :unav
DOI: 10.15454/updpdt/pgtfag
title: elda.py

description: :unav
DOI: 10.15454/updpdt/antkpd
title: xlsx_a_with_excel_link.XLSX

description: :unav
DOI: 10.15454/updpdt/jkxdil
title: EldaTemplate.pptx

description: :unav
DOI: 10.15454/updpdt/cgm53g
title: eldam-crashes-when-i-try-to-open-a-simapro-xlsx-export.rst

description: :unav
DOI: 10.15454/updpdt/bvfuft
title: simapro_to_elda.ui

description: :unav
DOI: 10.15454/updpdt/vqiagf
title: simapro.py

description: :unav
DOI: 10.15454/updpdt/zwbwoa
title: elda_index.png

description: :unav
DOI: 10.15454/updpdt/8ym80e
title: copy_elda_metadata.py

description: :unav
DOI: 10.15454/updpdt/bhqcte
title: __init__.py

description: :unav
DOI: 10.15454/updpdt/iw9opi
title: flows.png

description: :unav
DOI: 10.15454/updpdt/7xtmho
title: CHANGELOG.rst

description: :unav
DOI: 10.15454/updpdt/wtutt7
title: status_sheet.png

description: :unav
DOI: 10.15454/updpdt/7ynfhs
title: __init__.py

description: :unav
DOI: 10.15454/updpdt/8zihob
title: updating_elda_template.rst

description: :unav
DOI: 10.15454/updpdt/glosle
title: xlsx_a.XLSX

description: :unav
DOI: 10.15454/updpdt/j56usi
title: review_data.png

description: :unav
DOI: 10.15454/updpdt/lyh75k
title: simapro_import_summary.png

description: :unav
DOI: 10.15454/updpdt/phsaxo
title: value_change.png

description: :unav
DOI: 10.15454/updpdt/tvxfnc
title: update_test_files.py

description: :unav
DOI: 10.15454/updpdt/w2balu
title: test_calculated_parameter.py

description: :unav
DOI: 10.15454/updpdt/3rp6w6
title: technosphere_flow_comment.jinja2

description: :unav
DOI: 10.15454/updpdt/h3mift
title: eldam_simapro_to_elda.png

description: :unav
DOI: 10.15454/updpdt/euvgz6
title: reading_from_elda.rst

description: :unav
DOI: 10.15454/updpdt/wadhxd
title: flows2.png

description: :unav
DOI: 10.15454/updpdt/0ok0f3
title: elsa_logo.png

description: :unav
DOI: 10.15454/updpdt/ks9bhf
title: index.rst

description: :unav
DOI: 10.15454/updpdt/m1s3ch
title: csv_b_without_elda_only_data.csv

description: :unav
DOI: 10.15454/updpdt/autrxr
title: parameters.py

description: :unav
DOI: 10.15454/updpdt/lizsnu
title: elda_a_with_process_b_metadata.xlsm

description: :unav
DOI: 10.15454/updpdt/kb9r2n
title: testing.rst

description: :unav
DOI: 10.15454/updpdt/4fggaf
title: product_type_error_warning2.png

description: :unav
DOI: 10.15454/updpdt/erlmq7
title: xls.py

description: :unav
DOI: 10.15454/updpdt/3aloiw
title: elda_index.py

description: :unav
DOI: 10.15454/updpdt/myrd4k
title: back.png

description: :unav
DOI: 10.15454/updpdt/vrsdvd
title: compare_simapro_excel.svg

description: :unav
DOI: 10.15454/updpdt/aljycd
title: cx_setup.py

description: :unav
DOI: 10.15454/updpdt/lk94v5
title: about.svg

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DOI: 10.15454/updpdt/vdmr7x
title: lci_data.py

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DOI: 10.15454/updpdt/gvafkd
title: from-elda-to-simapro.rst

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DOI: 10.15454/updpdt/6wket8
title: eldam_main_screen.png

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DOI: 10.15454/updpdt/6rt6m8
title: exception_hook.py

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DOI: 10.15454/updpdt/bjwthb
title: lci_data.py

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DOI: 10.15454/updpdt/did7yn
title: simapro_lca_explorer.png

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DOI: 10.15454/updpdt/yfgh1v
title: elda_a_with_old_template.xlsm

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DOI: 10.15454/updpdt/acpdb3
title: blank_elda.py

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DOI: 10.15454/updpdt/pvaxh5
title: generate_elda_index.png

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DOI: 10.15454/updpdt/kmnr8k
title: Makefile

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DOI: 10.15454/updpdt/u5ovrf
title: blank_elda.png

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DOI: 10.15454/updpdt/0trvnw
title: eldam_bug.png

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DOI: 10.15454/updpdt/ygiqnp
title: xlsx_a_convert_expressions_to_constants.XLSX

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DOI: 10.15454/updpdt/sofasa
title: test_xls.py

description: :unav
DOI: 10.15454/updpdt/fd2ujg
title: elda_layout_modification.rst

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DOI: 10.15454/updpdt/guwx4l
title: code_stats.py

description: :unav
DOI: 10.15454/updpdt/w4rcxb
title: difference-between-process-and-product-name.rst

description: :unav
DOI: 10.15454/updpdt/xl7bre
title: libssl-1_1.dll

description: :unav
DOI: 10.15454/updpdt/blqsz7
title: elda_for_screen_captures.xlsm

description: :unav
DOI: 10.15454/updpdt/ioudrg
title: mainwindow.ui

description: :unav
DOI: 10.15454/updpdt/xb4d17
title: styles.py

description: :unav
DOI: 10.15454/updpdt/30ewkg
title: mass_balance.png

description: :unav
DOI: 10.15454/updpdt/ooap3j
title: eldam_elda_to_simapro.png

description: :unav
DOI: 10.15454/updpdt/ep9epw
title: test_integration.py

description: :unav
DOI: 10.17632/zdmthbkcgj.1
title: Ferrucci et al., 2020. Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple negative breast cancer. iSCIENCE-D-20-01279. FiguresHigherResolution

description: Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer Veronica Ferrucci et al., iSCIENCE-D-20-01279. Abstract: M2 tumor-associated macrophages (M2-TAMs) in the tumor microenvironment represent a prognostic indicator for poor outcome in triple-negative breast cancer (TNBC). Here we show that Prune-1 overexpression in human TNBC patients has positive correlation to lung metastasis and infiltrating M2-TAMs. Thus, we demonstrate that Prune-1 promotes lung metastasis in a genetically engineered mouse model of metastatic TNBC augmenting M2-polarization of TAMs within the tumor microenvironment. Thus, this occurs through TGF-β enhancement, IL-17F secretion and extracellular vesicle protein content modulation. We also find murine inactivating gene variants in human TNBC patient cohorts that are involved in activation of the innate immune response, cell adhesion, apoptotic pathways, and DNA repair. Altogether we indicate that the overexpression of Prune-1, IL-10, COL4A1, ILR1, and PDGFB, together with inactivating mutations of PDE9A, CD244, Sirpb1b, SV140, Iqca1, and PIP5K1B genes, might represent a route of metastatic lung dissemination which need future prognostic validations. Below are Figures of the manuscript in Higher Resoltion
DOI: 10.15454/updpdt/l5wojv
title: export_setup.PNG

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DOI: 10.15454/updpdt/zdkree
title: changelog.rst

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DOI: 10.15454/updpdt/atucd4
title: exit.png

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DOI: 10.15454/updpdt/ytodyp
title: test_input_parameter.py

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DOI: 10.15454/updpdt/ioxnir
title: CONTRIBUTING.md

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DOI: 10.15454/updpdt/p30fs0
title: excel2simapro.svg

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DOI: 10.15454/updpdt/9tfla7
title: indexing_elda_files.rst

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DOI: 10.15454/updpdt/qjsg2g
title: biosphere_flow_comment.jinja2

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DOI: 10.15454/updpdt/bjjn0r
title: elda_a_with_excel_link.xlsm

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DOI: 10.15454/updpdt/ojuf75
title: compare_simapro_excel.png

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DOI: 10.15454/updpdt/xkukfc
title: xlsx_d.XLSX

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DOI: 10.15454/updpdt/hx5wks
title: update_elda_template.py

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DOI: 10.15454/updpdt/qxedqg
title: flows1.png

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DOI: 10.15454/updpdt/v1ppbp
title: blank_elda.ui

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DOI: 10.15454/updpdt/hondol
title: calculated_parameters.png

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DOI: 10.15454/updpdt/jdj35d
title: simapro2excel.png

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DOI: 10.15454/updpdt/l0ytgj
title: parameters_and_settings.rst

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DOI: 10.15454/updpdt/8jbjqw
title: EldaIndex.xlsx

description: :unav