cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/jiq6dn
title: PDB - 5Y9J: BAFF in complex with belimumab, (312K, 39°C, 100 ns), random seed #2

description: PDB - 5Y9J: BAFF in complex with belimumab, (312K, 39°C, 100 ns), random seed #2.
DOI: 10.3535/qg2-bp5-bm7
title: Macdunnoughia (Macdunnoughia) confusa (Stephens, 1850)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/whp-b6s-aa5
title: Animalia

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/3st-cpm-r86
title: Agonopterix liturosa Haworth, 1811

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/0v6-h5c-sm7
title: Macdunnoughia (Macdunnoughia) confusa (Stephens, 1850)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/zgw-hk9-0b6
title: Oligia latruncula ([Denis & Schiffermüller], 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30903287
title: Supplementary Material for: Dental caries in preschool twins: coincidences, heritability, and associated factors in a cross-sectional census-based study

description: Introduction: Dental caries is a sugar-dependent biofilm disease influenced by multiple factors, yet the genetic contribution to its development remains a subject of debate. Method: A cross-sectional census study was conducted with preschool children aged from three to five years old in Teresina, Brazil. Twin pairs (MZ or DZ) with complete or mixed primary dentition up to the eruption of the permanent lower incisors were included. Uncooperative children were excluded. Data were collected through questionnaires and clinical examinations using the ICDAS index. Tetrachoric correlations and multinomial logistic regression were used to assess coincidences. Multilevel Poisson regression identified associated factors (p&lt;0.05). Results: Of the 325 eligible twin pairs, 219 (67.4%) participated in the data collection (87 MZ and 132 DZ). MZ twins exhibited a strong positive correlation for the presence of any lesion (rMZ=0.776) and a very strong positive correlation for ICDAS 4+ lesions (rMZ=0.920). DZ twins exhibited a moderate positive correlation for any lesion (rDZ=0.581) and a strong positive correlation for ICDAS 4+ lesions (rDZ=0.634). Environmental variables explained up to 50.6% of the variance in hierarchical models. Risk factors included being aged four to five years (OR=2.650; p=0.001), breastfeeding for six months or longer (OR=2.172; p=0.005), use of fluoride-free toothpaste (OR=2.444; p=0.004) and presence of hypomineralization of second primary molars (HSPM) (OR=2.198; p=0.005). Fluoridated water (OR=0.239; p=0.001) was a protective factor. Conclusion: While environmental factors play a significant role in the onset of dental caries, genetic factors may contribute to the development of the disease.
DOI: 10.6084/m9.figshare.30903287.v1
title: Supplementary Material for: Dental caries in preschool twins: coincidences, heritability, and associated factors in a cross-sectional census-based study

description: Introduction: Dental caries is a sugar-dependent biofilm disease influenced by multiple factors, yet the genetic contribution to its development remains a subject of debate. Method: A cross-sectional census study was conducted with preschool children aged from three to five years old in Teresina, Brazil. Twin pairs (MZ or DZ) with complete or mixed primary dentition up to the eruption of the permanent lower incisors were included. Uncooperative children were excluded. Data were collected through questionnaires and clinical examinations using the ICDAS index. Tetrachoric correlations and multinomial logistic regression were used to assess coincidences. Multilevel Poisson regression identified associated factors (p&lt;0.05). Results: Of the 325 eligible twin pairs, 219 (67.4%) participated in the data collection (87 MZ and 132 DZ). MZ twins exhibited a strong positive correlation for the presence of any lesion (rMZ=0.776) and a very strong positive correlation for ICDAS 4+ lesions (rMZ=0.920). DZ twins exhibited a moderate positive correlation for any lesion (rDZ=0.581) and a strong positive correlation for ICDAS 4+ lesions (rDZ=0.634). Environmental variables explained up to 50.6% of the variance in hierarchical models. Risk factors included being aged four to five years (OR=2.650; p=0.001), breastfeeding for six months or longer (OR=2.172; p=0.005), use of fluoride-free toothpaste (OR=2.444; p=0.004) and presence of hypomineralization of second primary molars (HSPM) (OR=2.198; p=0.005). Fluoridated water (OR=0.239; p=0.001) was a protective factor. Conclusion: While environmental factors play a significant role in the onset of dental caries, genetic factors may contribute to the development of the disease.
DOI: 10.3535/e08-bcf-vwj
title: Macdunnoughia (Macdunnoughia) confusa (Stephens, 1850)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/tyv-g9j-170
title: Leptidea sinapis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/2wr-9xc-390
title: Eurois occulta Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/maa-n3x-9d3
title: Lycaena virgaureae (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/g2b-yml-d5h
title: Agonopterix liturosa Haworth, 1811

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/j3v-892-4d3
title: Xanthorhoe biriviata (Borkhausen, 1794)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/e21-k3y-yv3
title: Hypena crassalis (Fabricius, 1787)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/7pf-97r-ckr
title: Xestia (Pachnobia) speciosa Hübner, 1813

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/gsf-wf9-r4q
title: Catoptria furcatellus Zetterstedt, 1840

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30903290
title: Supplementary Material for: Flare reaction Following Tarlatamab Treatment in a Patient with Extensive-Stage Small Cell Lung Cancer: Case Report

description: Introduction: Tarlatamab is a bispecific T cell engager (BiTE) targeting DLL3 and shows promising efficacy in relapsed small cell lung cancer (SCLC). Although flare reactions are recognized with immune checkpoint inhibitors, reports in patients receiving tarlatamab remain limited. 

Case Presentation: We describe the case of a 74-year-old woman with extensive-stage SCLC who developed acute radiological worsening within four days after initiating third-line tarlatamab therapy, followed by rapid improvement by Day 8. Chest computed tomography performed one week prior to treatment and on Day 1 revealed no significant changes in the right hilar mass size (56.5 mm vs. 54.0 mm) or the right lower lobe infiltrating shadow (82.5 mm vs. 82.0 mm). On Day 4, the right hilar mass and lower lobe lesion increased to 68.0 mm and 74.1 mm, respectively, along with surrounding ground-glass opacity and pleural effusion. By Day 8, these lesions had decreased to 56.3 mm and 73.8 mm, respectively, and were further reduced by Day 15 to 54.1 mm and 73.3 mm, respectively, with complete resolution of pleural effusion. Cytokine release syndrome (Grade 1–2) was noted with tarlatamab administration on Days 1, 8, and 15. Based on the temporal association, imaging findings, and clinical course, the event was considered flare reaction rather than natural tumor progression. 

Conclusion: Our findings suggest that flare reaction occurs within days of initiating tarlatamab, possibly attributable to acute immune activation, as reported in BiTE therapies. Awareness of this possibility may help avoid premature discontinuation of effective treatment.
DOI: 10.6084/m9.figshare.30903290.v1
title: Supplementary Material for: Flare reaction Following Tarlatamab Treatment in a Patient with Extensive-Stage Small Cell Lung Cancer: Case Report

description: Introduction: Tarlatamab is a bispecific T cell engager (BiTE) targeting DLL3 and shows promising efficacy in relapsed small cell lung cancer (SCLC). Although flare reactions are recognized with immune checkpoint inhibitors, reports in patients receiving tarlatamab remain limited. 

Case Presentation: We describe the case of a 74-year-old woman with extensive-stage SCLC who developed acute radiological worsening within four days after initiating third-line tarlatamab therapy, followed by rapid improvement by Day 8. Chest computed tomography performed one week prior to treatment and on Day 1 revealed no significant changes in the right hilar mass size (56.5 mm vs. 54.0 mm) or the right lower lobe infiltrating shadow (82.5 mm vs. 82.0 mm). On Day 4, the right hilar mass and lower lobe lesion increased to 68.0 mm and 74.1 mm, respectively, along with surrounding ground-glass opacity and pleural effusion. By Day 8, these lesions had decreased to 56.3 mm and 73.8 mm, respectively, and were further reduced by Day 15 to 54.1 mm and 73.3 mm, respectively, with complete resolution of pleural effusion. Cytokine release syndrome (Grade 1–2) was noted with tarlatamab administration on Days 1, 8, and 15. Based on the temporal association, imaging findings, and clinical course, the event was considered flare reaction rather than natural tumor progression. 

Conclusion: Our findings suggest that flare reaction occurs within days of initiating tarlatamab, possibly attributable to acute immune activation, as reported in BiTE therapies. Awareness of this possibility may help avoid premature discontinuation of effective treatment.
DOI: 10.3535/brb-y6f-mdn
title: Sideridis (Heliophobus) reticulata Goeze, 1781

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/me1-gze-044
title: Xylena (Lithomoia) solidaginis Hübner, 1803

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30903293
title: Supplementary Material for: Patterns and Prognostic Stratification of Recurrence After Thermal Ablation in Patients with Hepatocellular Carcinoma

description: Background 
Recurrence rates following thermal ablation for hepatocellular carcinoma (HCC) remain high, but the patterns of recurrence and post-recurrence outcomes are not well characterized. This study aimed to investigate the recurrence patterns and long-term post-recurrence survival (PRS) in patients with HCC after thermal ablation to inform post-recurrence treatment strategy.
Methods 
A retrospective analysis was conducted on 824 patients who underwent thermal ablation for HCC between 2007 and 2023. Recurrence patterns and factors influencing PRS in patients with recurrence within and beyond the Milan criteria were evaluated. An independent cohort of 198 patients served as an external validation cohort for the prognostic models.
Results
During a median follow up of 54.5 month, 536 patients experienced HCC recurrence, with 83.8% within and 16.2% beyond Milan criteria. For patients with recurrence within Milan criteria, early recurrence, recurrent tumor size, AFP, ALBI grade, and FIB-4 score were independent predictors of PRS. In patients with recurrence beyond Milan criteria, diabetes mellitus, macrovascular invasion, AFP, ALBI grade, and FIB-4 score independently predicted PRS. Based on PRS predictors, a risk model stratified patients with recurrence within Milan criteria into four risk groups, with median PRS of 103.7, 65, 48.7 and 28.6 months, respectively (p&lt;0.001). For recurrence beyond Milan criteria, a separate risk model classified patients into three risk groups, showing median PRS of 70.1, 24.7, and 8.1 months, along with probabilities of successful downstaging of 66.7%, 39.3%, and 0%, respectively (p&lt;0.001). The external validation results showed that both the Milan-in and Milan-out models demonstrated significant discriminative performance in the validation cohort.
Conclusions 
PRS in patients with recurrent HCC after thermal ablation is significantly influenced by recurrence patterns, tumor characteristics, and host factors. These findings may guide post-recurrence treatment strategies and optimize the timing of salvage liver transplantation.
DOI: 10.6084/m9.figshare.30903293.v1
title: Supplementary Material for: Patterns and Prognostic Stratification of Recurrence After Thermal Ablation in Patients with Hepatocellular Carcinoma

description: Background 
Recurrence rates following thermal ablation for hepatocellular carcinoma (HCC) remain high, but the patterns of recurrence and post-recurrence outcomes are not well characterized. This study aimed to investigate the recurrence patterns and long-term post-recurrence survival (PRS) in patients with HCC after thermal ablation to inform post-recurrence treatment strategy.
Methods 
A retrospective analysis was conducted on 824 patients who underwent thermal ablation for HCC between 2007 and 2023. Recurrence patterns and factors influencing PRS in patients with recurrence within and beyond the Milan criteria were evaluated. An independent cohort of 198 patients served as an external validation cohort for the prognostic models.
Results
During a median follow up of 54.5 month, 536 patients experienced HCC recurrence, with 83.8% within and 16.2% beyond Milan criteria. For patients with recurrence within Milan criteria, early recurrence, recurrent tumor size, AFP, ALBI grade, and FIB-4 score were independent predictors of PRS. In patients with recurrence beyond Milan criteria, diabetes mellitus, macrovascular invasion, AFP, ALBI grade, and FIB-4 score independently predicted PRS. Based on PRS predictors, a risk model stratified patients with recurrence within Milan criteria into four risk groups, with median PRS of 103.7, 65, 48.7 and 28.6 months, respectively (p&lt;0.001). For recurrence beyond Milan criteria, a separate risk model classified patients into three risk groups, showing median PRS of 70.1, 24.7, and 8.1 months, along with probabilities of successful downstaging of 66.7%, 39.3%, and 0%, respectively (p&lt;0.001). The external validation results showed that both the Milan-in and Milan-out models demonstrated significant discriminative performance in the validation cohort.
Conclusions 
PRS in patients with recurrent HCC after thermal ablation is significantly influenced by recurrence patterns, tumor characteristics, and host factors. These findings may guide post-recurrence treatment strategies and optimize the timing of salvage liver transplantation.
DOI: 10.3535/9y3-b0p-fyq
title: Thumatha senex (Hübner, 1804)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/lpm-4r5-he1
title: Agriades Hübner, 1819

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/hda-yp0-2z6
title: Lithophane (Lithophane) furcifera Hufnagel, 1766

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/tk7-axc-mfv
title: Orthosia (Semiophora) Stephens, 1829

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30903296
title: Supplementary Material for: The Role of Inflammation and High-Sensitivity C-reactive Protein in Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease: the FLAME-ASCVD Survey Among Nephrologists

description: Background: Systemic inflammation (SI) contributes to increased cardiovascular risk in patients with atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD). We assessed clinical perceptions toward SI and usage of high-sensitivity C-reactive protein (hsCRP) among nephrologists.
Methods: FLAME-ASCVD Nephro was an online survey of nephrologists from 10 countries who treat ≥20 patients with ASCVD and CKD a month and were practicing for ≥3 years. Results were analyzed using descriptive statistics. 
Results: Of 513 nephrologists who responded, 300 completed and were included in the survey; the mean age was 46 years and the mean time in practice was 16 years. Hypertension (89%), overweight/obesity (81%), and CKD (80%) were the ASCVD risk factors most often discussed with patients (SI was ninth). The most common unmet needs (ranked 1-3) for patients with ASCVD and CKD were “lack of effective SI treatment options” (44%), “limited awareness of the role of SI in ASCVD” (35%) and “higher risk of CV events” (33%). Seventy-four percent of nephrologists wanted to learn more about the role of SI in ASCVD and 71% test for and use SI results when determining management approaches. Seventy percent of nephrologists considered hsCRP testing in patients with ASCVD and CKD (aided), and proven clinical efficacy of hsCRP was the top reason (37%); out-of-pocket cost (30%) was the most common reason for not considering hsCRP testing.
Conclusion: Lack of effective treatment options for SI remains the most common unmet need for patients with ASCVD and CKD. Further medical education is needed to raise awareness among nephrologists about the role of SI and hsCRP testing.
DOI: 10.6084/m9.figshare.30903296.v1
title: Supplementary Material for: The Role of Inflammation and High-Sensitivity C-reactive Protein in Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease: the FLAME-ASCVD Survey Among Nephrologists

description: Background: Systemic inflammation (SI) contributes to increased cardiovascular risk in patients with atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD). We assessed clinical perceptions toward SI and usage of high-sensitivity C-reactive protein (hsCRP) among nephrologists.
Methods: FLAME-ASCVD Nephro was an online survey of nephrologists from 10 countries who treat ≥20 patients with ASCVD and CKD a month and were practicing for ≥3 years. Results were analyzed using descriptive statistics. 
Results: Of 513 nephrologists who responded, 300 completed and were included in the survey; the mean age was 46 years and the mean time in practice was 16 years. Hypertension (89%), overweight/obesity (81%), and CKD (80%) were the ASCVD risk factors most often discussed with patients (SI was ninth). The most common unmet needs (ranked 1-3) for patients with ASCVD and CKD were “lack of effective SI treatment options” (44%), “limited awareness of the role of SI in ASCVD” (35%) and “higher risk of CV events” (33%). Seventy-four percent of nephrologists wanted to learn more about the role of SI in ASCVD and 71% test for and use SI results when determining management approaches. Seventy percent of nephrologists considered hsCRP testing in patients with ASCVD and CKD (aided), and proven clinical efficacy of hsCRP was the top reason (37%); out-of-pocket cost (30%) was the most common reason for not considering hsCRP testing.
Conclusion: Lack of effective treatment options for SI remains the most common unmet need for patients with ASCVD and CKD. Further medical education is needed to raise awareness among nephrologists about the role of SI and hsCRP testing.
DOI: 10.3535/3z1-76z-z3g
title: Trichopteryx polycommata ([Denis & Schiffermüller], 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.15468/dl.x2xjcr
title: Occurrence Download

description: A dataset containing 17714 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vespa velutina",
 "Country is Germany",
 "BasisOfRecord is Human Observation",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 17714 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0056203-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/9eb-v7a-07j
title: Cidaria fulvata (Forster, 1771)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/eyn-691-5cy
title: Brenthis ino (von Rottemburg, 1775)

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.6084/m9.figshare.30903299
title: Supplementary Material for: Are Area-Level Socioeconomic Factors Associated with Dental Caries and Tooth Loss? A Systematic Review

description: Introduction: Area-level socioeconomic factors are within the social determinants of health, encompassing conditions in which people are born, grow, live, work, and age, which influence health beyond individual characteristics. This review examines the association between area-level socioeconomic factors and dental caries and tooth loss. The hypothesis is that individuals residing in more socioeconomically deprived areas experience higher odds of dental caries and tooth loss, independent of individual socioeconomic status.

Methods: A systematic search was conducted in PubMed, Scopus, Embase, and Web of Science. Studies reporting clinical or self-reported dental caries or tooth loss, and evaluating area-level socioeconomic deprivation or income (neighbourhood, municipality, or region) using multilevel models were included. 

Results: Of 4,671 screened records, 44 studies (41 cross-sectional) published from 2006 to 2024 were included. The most common exposures were area socioeconomic deprivation indices (n=24), area average income (n=21), and the Human Development Index (HDI) (n=13). Quantitative synthesis was precluded by heterogeneity of aggregation levels, outcomes (tooth loss, caries experience, and untreated caries), and outcome measurement (dichotomous/continuous). Most studies adjusted for individual-level socioeconomic factors (82%). The hypothesised association was most consistent for tooth loss (e.g. functional dentition or edentulism, 6/6 studies), at a medium level of aggregation (13/15), and for the HDI (10/13). Studies using ordered categories frequently demonstrated clear socioeconomic gradients.

Conclusion: The findings support the hypothesis that residing in more affluent areas is associated with better oral health outcomes, specifically lower levels of tooth loss and, to a lesser extent, dental caries, after adjusting for individual-level socioeconomic factors.