DOI: 10.5061/dryad.dbrv15fgk
title: Ex-vivo MRI of human brain hemispheres from patients with globular glial tauopathy and one typical control

description: Ex vivo whole-hemisphere T2*-weighted MRI of 6 human brain hemispheres, 5
 from patients with globular glial tauopathy (GGT) and 1 from a typically
 aging patient. MRI data is stored as NIFTI files, with one file per
 hemisphere. Gradient echo times were chosen to be approximately 20 ms to
 maximize sensitivity to GGT pathology.
description: Samples were placed in Fomblin (California Vacuum Technology;
 Freemont, CA), a proton-free fluid with volume magnetic susceptibility
 close to that of tissue. Samples were enclosed in either custom-build
 cylindrical holders or plastic bags, and then left to rest for at least
 two days to allow air bubbles to escape from the tissue. Depending on
 their size, samples were scanned using either a custom-built birdcage coil
 or a custom-modified quadrature birdcage (Varian, Palo Alto, CA, USA)
 coil. These transmit/receive coils were attached to a two-channel
 transmit-receive adapter (Stark Contrast, Erlangen, Germany). The smallest
 coil was chosen that could hold each sample, tuned/matched by hand, and
 then placed into our whole-body 7 T scanner (MAGNETOM Terra, Siemens
 Healthineers, Erlangen, Germany) using plastic shims under the coils to
 position the sample near isocenter. MRI data were
 acquired with a 3D-encoded, multi-echo gradient-recalled echo (GRE)
 sequence with non-selective RF pulses. The final echo was followed by an
 additional completely rephrased readout to measure frequency drifts. Scans
 for individual patients were acquired with somewhat different scanning
 protocols, reflecting the evolution of standard practices at our imaging
 center. Specific details of the scanning parameters for each patient are
 listed in the associated journal article:
 Clinicoanatomic localization of iron-rich gliosis in aphasic
 presentations of globular glial tauopathy, Brain Communications, in
 press Images were reconstructed using the vendor’s
 on-scanner reconstruction software which automatically corrected the
 global frequency drift, combined the signal averages in k-space, and
 produced magnitude images for each echo.
description: # Ex vivo MRI of human brain hemispheres from patients with globular glial
 tauopathy and one typical control Dataset DOI:
 [10.5061/dryad.dbrv15fgk](https://doi.org/10.5061/dryad.dbrv15fgk) ##
 Description of the data and file structure ``` For questions related to
 this dataset, please contact Dylan Tisdall
 (mtisdall@pennmedicine.upenn.edu). Image data is in NIFTI format,
 organized with one file per patient. Imaging data dimensions are described
 in the NIFTI data headers. Details of the specific imaging parameters, as
 well as the patients' clinical and demographic information are
 included in the associated manuscript. ``` ### Files and variables ####
 File: sub-patient1_acq-280um_echo-3_FLASH.nii.gz **Description:** NIFTI
 file of ex vivo MRI for patient 1, 280 um isotropic resolution #### File:
 sub-patient2_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
 ex vivo MRI for patient 2, 160 um isotropic resolution #### File:
 sub-patient3_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
 ex vivo MRI for patient 3, 160 um isotropic resolution #### File:
 sub-patient4_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
 ex vivo MRI for patient 4, 160 um isotropic resolution #### File:
 sub-patient5_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
 ex vivo MRI for patient 5, 160 um isotropic resolution #### File:
 sub-patient6_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
 ex vivo MRI for patient 6, 160 um isotropic resolution #### ## Human
 subjects data Consent to publish de-identified data was received as part
 of the research protocol approved by the University of Pennsylvania's
 IRB. All PII has been removed from image headers, and no identifying
 information is included in the associated manuscript.