cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb1920585-2
title: Acidity in zeolites - A MuSR perspective

description: Zeolites are microporous materials that are used as heterogeneous acid catalysts in reactions. It is important to study reactive intermediates in zeolites in order to understand the catalytic reactions in these important materials. Avoided Level Crossing muon Spin Resonance will be used to characterize pyridine radicals in zeolites with the variation of Si/Al ratio and with temperature. The silica to aluminium ratio (Si/Al) of ZSM-5 should determine the number of available Brønsted acid sites that may interact with pyridine molecules. This experiment tries to answer an open question regarding how sensitive is MuSR spectroscopy to the chemistry of the acid sites in the most widely employed acid catalysts. Understanding acidity in zeolites is still an open discussion among the zeolite community and we believe our approach will shed light on the structure of acidity.
DOI: 10.5286/isis.e.rb1920679-1
title: Magnetic Excitations in a Possible Quantum Ferromagnet

description: The proposed experiment is to measure in considerable detail the magnetic excitations inY2V2O7. Bulk measurements on this pyrochlore magnet show that it is a ferromagnet with a transition temperature close to 70 K. Like its counterpart, Lu2V2O7, we expect Y2V2O7 to have significant Dzyaloshinskii-Moriya exchange (DM) leading to a nontrivial Berry curvature and unusual thermal transport properties as well as characteristic magnon damping. Even more interesting, Y2V2O7 is a strong candidate to host Weyl points in its magnon band structure which have not been observed before. Their presence would imply the presence of topologically-protected surface states and potentially other unusual properties. Our experiment will enable us to carry out a complete characterization of the magnetic exchange in this material and potentially observe the magnetic Weyl points.
DOI: 10.5286/isis.e.rb1920012
title: Stochastic Cation Dynamics in Photovoltaic Hybrid Perovskites under Pressure

description: Methylammonium lead iodide (MAPI) is one the most promising materials for photovoltaics. Notwithstanding the above, access to its phase diagram and the underlying structural & dynamical properties has not been a trivial task. Building upon our recent study on TOSCA [J Phys Chem Lett 7 (2016) 4701], this proposal seeks to extend this work along the pressure axis using OSIRIS, in order to probe the onset and underlying nature of stochastic motions of the organic cation. Given the soft nature of the material, phase transitions occur at relatively low pressures ca. 0.3-0.4 GPa, yet their precise nature remains a matter of debate. In combination with synchronous diffraction on OSIRIS and computational modelling, neutron data over this pressure range and across the phase transition associated with cation ordering would pave the way for a detailed atomistic model of the material.
DOI: 10.5286/isis.e.rb1920012-1
title: Stochastic Cation Dynamics in Photovoltaic Hybrid Perovskites under Pressure

description: Methylammonium lead iodide (MAPI) is one the most promising materials for photovoltaics. Notwithstanding the above, access to its phase diagram and the underlying structural & dynamical properties has not been a trivial task. Building upon our recent study on TOSCA [J Phys Chem Lett 7 (2016) 4701], this proposal seeks to extend this work along the pressure axis using OSIRIS, in order to probe the onset and underlying nature of stochastic motions of the organic cation. Given the soft nature of the material, phase transitions occur at relatively low pressures ca. 0.3-0.4 GPa, yet their precise nature remains a matter of debate. In combination with synchronous diffraction on OSIRIS and computational modelling, neutron data over this pressure range and across the phase transition associated with cation ordering would pave the way for a detailed atomistic model of the material.
DOI: 10.5286/isis.e.rb1920102
title: The chemical interaction and confinement effect of molecules in the sol-gel AlPO4 mesoporous glasses

description: Owing to the separation in the mesoscale and confinement effect of mesostructured pores to the molecule, mesoporous materials have been widely applied as matrices of host-guest organic-inorganic materials, adsorbents or catalysts. To date, the most developed mesoporous materials concentrated on silica and carbon-based system, as the neutral SiO4 and C skeletons lack the acidic sites which is still the main hurdle for the widespread application of mesoporous materials. We developed a transparent and colourless stoichiometric AlPO4 monolith glass possessing a highly mesoporous structure with chemical activities as a results of alternating AlO4- and PO4- tetrahedra framework. The detailed understanding of the molecules confinement mechanism in M-AP will also lead to better design of phosphate mesoporous materials as luminescent hosts and catalysts.
DOI: 10.5286/isis.e.rb1920102-1
title: The chemical interaction and confinement effect of molecules in the sol-gel AlPO4 mesoporous glasses

description: Owing to the separation in the mesoscale and confinement effect of mesostructured pores to the molecule, mesoporous materials have been widely applied as matrices of host-guest organic-inorganic materials, adsorbents or catalysts. To date, the most developed mesoporous materials concentrated on silica and carbon-based system, as the neutral SiO4 and C skeletons lack the acidic sites which is still the main hurdle for the widespread application of mesoporous materials. We developed a transparent and colourless stoichiometric AlPO4 monolith glass possessing a highly mesoporous structure with chemical activities as a results of alternating AlO4- and PO4- tetrahedra framework. The detailed understanding of the molecules confinement mechanism in M-AP will also lead to better design of phosphate mesoporous materials as luminescent hosts and catalysts.
DOI: 10.5286/isis.e.rb1968069
title: Binding studies of Quantum Dots and Pore-Forming Proteins on multi-component model cell membranes

description: Cell membrane being the first line of defence of a complex cell, it forms an important scientific topic to study its encounter with various external entities. Nanoparticles are an important topic because of its applications like drug delivery. On the other hand, pore-forming proteins like listeriolysin O, present in virulent bacteria, bind to target membrane and cause cell lysis. This study aims to use Neutron Reflectivity as a powerful technique to understand the binding profile and penetration of protein/nanoparticles and the resultant modifications in molecular conformation of the different multi-component model cell membranes tuned by differently entropic and charged lipids to control the preferential binding of the charged/uncharged nanoparticles and also understand the cell lysis mechanism of the pore-forming protein LLO.
DOI: 10.5286/isis.e.rb1968069-1
title: Binding studies of Quantum Dots and Pore-Forming Proteins on multi-component model cell membranes

description: Cell membrane being the first line of defence of a complex cell, it forms an important scientific topic to study its encounter with various external entities. Nanoparticles are an important topic because of its applications like drug delivery. On the other hand, pore-forming proteins like listeriolysin O, present in virulent bacteria, bind to target membrane and cause cell lysis. This study aims to use Neutron Reflectivity as a powerful technique to understand the binding profile and penetration of protein/nanoparticles and the resultant modifications in molecular conformation of the different multi-component model cell membranes tuned by differently entropic and charged lipids to control the preferential binding of the charged/uncharged nanoparticles and also understand the cell lysis mechanism of the pore-forming protein LLO.
DOI: 10.5286/isis.e.rb1970114
title: Superconducting Pairing Symmetry in a Hole-doped Organic Superconductor kappa-(ET)4Hg2.89Br8 probed by muSR

description: Organic superconductors (SCs) generally have fixed band filling as 1/2 or 1/4. But, kappa-(ET)4Hg2.89Br8 (k-HgBr) is an exceptional one because 11%-hole doping electronic state from the 1/2-filled band is realized, while ET dimers form the triangular lattice. In the metallic state under pressure, a non-Fermi liquid behavior was observed in the low-pressure range and gradually changed to a Fermi-liquid one with a critical pressure Pc~0.5 GPa. This metallic state undergoes SC with a broad transition width at 4.3 K. The upper critical field in the perpendicular configuration, Bc2, under low-pressure obviously exceeds Pauli limit, Bp. There is no example of that Bc2 exceeds Bp among organic SCs which may indicate the nature of triplet superconductivity. As the first step, we would like to clarify whether triplet SC is realized in k-HgBr at ambient pressure down to 0.3 K by zero-field muSR.
DOI: 10.5286/isis.e.rb1970114-1
title: Superconducting Pairing Symmetry in a Hole-doped Organic Superconductor kappa-(ET)4Hg2.89Br8 probed by muSR

description: Organic superconductors (SCs) generally have fixed band filling as 1/2 or 1/4. But, kappa-(ET)4Hg2.89Br8 (k-HgBr) is an exceptional one because 11%-hole doping electronic state from the 1/2-filled band is realized, while ET dimers form the triangular lattice. In the metallic state under pressure, a non-Fermi liquid behavior was observed in the low-pressure range and gradually changed to a Fermi-liquid one with a critical pressure Pc~0.5 GPa. This metallic state undergoes SC with a broad transition width at 4.3 K. The upper critical field in the perpendicular configuration, Bc2, under low-pressure obviously exceeds Pauli limit, Bp. There is no example of that Bc2 exceeds Bp among organic SCs which may indicate the nature of triplet superconductivity. As the first step, we would like to clarify whether triplet SC is realized in k-HgBr at ambient pressure down to 0.3 K by zero-field muSR.
DOI: 10.20392/7a9822b5-8eda-48f8-b648-9956eb7c859d
title: dab-1 (DAB (Drosophila disabled) homolog)

description: dab-1 encodes an ortholog of the cytoplasmic adaptor protein DISABLED, required for normal molting and meiotic arrest; DAB-1 is also required for EGL-17 secretion from vulval cells, and thus indirectly for normal sex myoblast (SM) migration and egg-laying; DAB-1 contains a conserved PTB domain and signals that confer localization to Golgi-proximal vesicles, and DAB-1 localizes to vesicular structures in vivo; dab-1 is expressed in ventral precursor cells, and DAB-1 prevents EGL-17 protein accumulation in them; dab-1 is also expressed in other cells (anchor cell, sheath cells, etc.) but has no obvious function in them; DAB-1 binds the cytoplasmic domains of either LRP-1 or LRP-2 in yeast two-hybrid experiments; dab-1(gk291) and dab-1(RNAi) animals have similar defects in molting, EGL-17 secretion from VPCs, SM migration, and egg-laying; dab-1(RNAi) does not enhance the SM phenotypes of lrp-1(RNAi) or lrp-2(RNAi), suggesting that these genes act in concert to promote normal EGL-17 secretion and SM migration; in vitro, DAB-1 binds to the ear domains of APT-4 (strongly) and of APT-1 and APT-9 (weakly); genetically, dab-1(RNAi) functions as part of the vab-1 pathway in oocytes inhibiting meiotic maturation, and DAB-1 is found in oocyte cytoplasm.
DOI: 10.5286/isis.e.rb1920049
title: NEW DIMENSIONS IN FORENSIC PROFILING: IMAGING BURNED HUMAN BONES AT IMAT

description: Neutron imaging at IMAT will be applied to the study of burned human skeletal remains, for assessing heat-induced changes associated to alterations in bone´s microcrystallinity. This work follows successful experiments on MAPS, TOSCA and GEM which were the first studies on human burned bones by neutron techniques and allowed us to identify spectral biomarkers of heat-elicited alterations [1-7]. Combined spectroscopic (including FTIR and Raman), diffraction and imaging methods are expected to provide an improved understanding of the variations undergone by bone upon burning. A quantitative relationship between these data, dimensional variations and burning conditions is sought, to relate burned to pre-burned parameters. This is an innovative way of tackling heat-induced changes in human bone, with a high impact in forensic profiling as well as in bioarchaeological investigation.
DOI: 10.5286/isis.e.rb1920049-1
title: NEW DIMENSIONS IN FORENSIC PROFILING: IMAGING BURNED HUMAN BONES AT IMAT

description: Neutron imaging at IMAT will be applied to the study of burned human skeletal remains, for assessing heat-induced changes associated to alterations in bone´s microcrystallinity. This work follows successful experiments on MAPS, TOSCA and GEM which were the first studies on human burned bones by neutron techniques and allowed us to identify spectral biomarkers of heat-elicited alterations [1-7]. Combined spectroscopic (including FTIR and Raman), diffraction and imaging methods are expected to provide an improved understanding of the variations undergone by bone upon burning. A quantitative relationship between these data, dimensional variations and burning conditions is sought, to relate burned to pre-burned parameters. This is an innovative way of tackling heat-induced changes in human bone, with a high impact in forensic profiling as well as in bioarchaeological investigation.
DOI: 10.5286/isis.e.rb1920068
title: Lipid nanoparticles-Apolipoprotein E interaction: the role of LNP surface composition and structure

description: Therapeutic treatments based on the production of proteins by delivering messenger RNA (mRNA) represent a promising approach. Lipid nanoparticles (LNPs) formed by a cationic ionizable lipid (CIL), DSPC, cholesterol and a pegylated lipid have been successful to deliver small interference RNA. The bio-distribution and cellular uptake of LNPs are affected by their surface composition as well as by the extracellular proteins present at the site of LNPs administration, e.g. ApolipoproteinE (ApoE). ApoE plays a key role in the LNPs circulation time. Our previous results show that both particle size and DSPC surface area affects the efficacy of LNPs. For an optimised LNP formulation, we aim to reveal the contribution of CIL and cholesterol to the LNP structure. Furthermore, we want to study the role of LNP surface structure on the ApoE binding and the structural change due to ApoE binding.
DOI: 10.5286/isis.e.rb1920068-1
title: Lipid nanoparticles-Apolipoprotein E interaction: the role of LNP surface composition and structure

description: Therapeutic treatments based on the production of proteins by delivering messenger RNA (mRNA) represent a promising approach. Lipid nanoparticles (LNPs) formed by a cationic ionizable lipid (CIL), DSPC, cholesterol and a pegylated lipid have been successful to deliver small interference RNA. The bio-distribution and cellular uptake of LNPs are affected by their surface composition as well as by the extracellular proteins present at the site of LNPs administration, e.g. ApolipoproteinE (ApoE). ApoE plays a key role in the LNPs circulation time. Our previous results show that both particle size and DSPC surface area affects the efficacy of LNPs. For an optimised LNP formulation, we aim to reveal the contribution of CIL and cholesterol to the LNP structure. Furthermore, we want to study the role of LNP surface structure on the ApoE binding and the structural change due to ApoE binding.
DOI: 10.5286/isis.e.rb1920625
title: Tracking changes in the phonon density of states in differently coated LixFePO4 nanoparticles

description: LiFePO4 (LFP) is a commercially used Li ion battery material for high power applications. Particle shape and surface play an important role in the Li diffusion and thus the electrochemical performance of the material. Additionally, the change of lithium content during cycling can affect the Li ion dynamics in the material. After the successful experiment addressing the particle shape, we propose to measure the phonon density of states of LFP as a function of surface coatings at different levels of lithium content. For this, we kindly request six days of beam time at MARI. This will give us further insights on how surface phonon modes play a role in the size-dependent behavior of the lithium ion diffusion in LFP.
DOI: 10.5286/isis.e.rb1920625-1
title: Tracking changes in the phonon density of states in differently coated LixFePO4 nanoparticles

description: LiFePO4 (LFP) is a commercially used Li ion battery material for high power applications. Particle shape and surface play an important role in the Li diffusion and thus the electrochemical performance of the material. Additionally, the change of lithium content during cycling can affect the Li ion dynamics in the material. After the successful experiment addressing the particle shape, we propose to measure the phonon density of states of LFP as a function of surface coatings at different levels of lithium content. For this, we kindly request six days of beam time at MARI. This will give us further insights on how surface phonon modes play a role in the size-dependent behavior of the lithium ion diffusion in LFP.
DOI: 10.5286/isis.e.rb1920700
title: How N-acyl amino acid surfactants adsorption at the air/water interface helps explaining atypical interaction with lipid membranes

description: N-acyl amino acids are promising anionic amphiphilic molecules, which consist of a linear aliphatic chain (hydrophobic tail) and an amino-acid residue (polar head). Although they have been mainly employed in cosmetics as detergents and foaming agents, these molecules seem to be also promising for pharmaceutical applications. Anionic amphiphiles, in fact, are used as excipients in pharmaceutical technology to improve solubilisation of poorly-water soluble drugs, to increase the wettability of solid dosage forms and/or to enhance drug penetration through biological membranes.Therefore, N-acyl amino acid surfactants could represent an alternative and safer option to sulfate-based anionic surfactants (e.g sodium dodecyl sulphate, SDS). Due to the lack of information regarding toxicity concerns of these surfactants, we performed a full characterization of their physicochemical properties.
DOI: 10.5286/isis.e.rb1920700-1
title: How N-acyl amino acid surfactants adsorption at the air/water interface helps explaining atypical interaction with lipid membranes

description: N-acyl amino acids are promising anionic amphiphilic molecules, which consist of a linear aliphatic chain (hydrophobic tail) and an amino-acid residue (polar head). Although they have been mainly employed in cosmetics as detergents and foaming agents, these molecules seem to be also promising for pharmaceutical applications. Anionic amphiphiles, in fact, are used as excipients in pharmaceutical technology to improve solubilisation of poorly-water soluble drugs, to increase the wettability of solid dosage forms and/or to enhance drug penetration through biological membranes.Therefore, N-acyl amino acid surfactants could represent an alternative and safer option to sulfate-based anionic surfactants (e.g sodium dodecyl sulphate, SDS). Due to the lack of information regarding toxicity concerns of these surfactants, we performed a full characterization of their physicochemical properties.
DOI: 10.5286/isis.e.rb1920700-2
title: How N-acyl amino acid surfactants adsorption at the air/water interface helps explaining atypical interaction with lipid membranes

description: N-acyl amino acids are promising anionic amphiphilic molecules, which consist of a linear aliphatic chain (hydrophobic tail) and an amino-acid residue (polar head). Although they have been mainly employed in cosmetics as detergents and foaming agents, these molecules seem to be also promising for pharmaceutical applications. Anionic amphiphiles, in fact, are used as excipients in pharmaceutical technology to improve solubilisation of poorly-water soluble drugs, to increase the wettability of solid dosage forms and/or to enhance drug penetration through biological membranes.Therefore, N-acyl amino acid surfactants could represent an alternative and safer option to sulfate-based anionic surfactants (e.g sodium dodecyl sulphate, SDS). Due to the lack of information regarding toxicity concerns of these surfactants, we performed a full characterization of their physicochemical properties.
DOI: 10.5281/zenodo.3571050
title: DESED_public_eval

description: Domestic environment sound event detection (DESED) dataset is described: In this page: https://project.inria.fr/desed/<br> This repo: https://github.com/turpaultn/DESED<br> These papers: https://hal.inria.fr/hal-02160855 and https://hal.inria.fr/hal-02355573v1. This dataset is the public evaluation (<strong>referred as "youtube" evaluation in papers</strong>) It is composed of real 10 seconds sound clips taken from Youtube with Creative Commons licenses.
DOI: 10.5286/isis.e.rb1900044
title: In-situ measurement of 3D stress distribution in Inconel 625 alloy during compression

description: This application is prepared according to the suggestion made by the panel for our RB1820187 application. In this application we request a day of Express time and will carry out a feasibility study for future work on in-situ hot compression experiments.Nickel based wrought Inconel 625 alloys are widely used for many applications due to their good mechanical properties, weldability and resistance to corrosion in aggressive environments. Hot extrusion technology is commonly used to manufacture Inconel 625 seamless pipes. However pipe bursting may occur during the hot extrusion and recent studies have reported that stress distribution during hot extrusion is the main factor affecting the pipe bursting of Inconel 625 alloy. To solve the pipe bursting problem, this experiment aims to in-situ measure 3D stress distribution in Inconel 625 alloy during compression at room temperature.
DOI: 10.5286/isis.e.rb1900044-1
title: In-situ measurement of 3D stress distribution in Inconel 625 alloy during compression

description: This application is prepared according to the suggestion made by the panel for our RB1820187 application. In this application we request a day of Express time and will carry out a feasibility study for future work on in-situ hot compression experiments.Nickel based wrought Inconel 625 alloys are widely used for many applications due to their good mechanical properties, weldability and resistance to corrosion in aggressive environments. Hot extrusion technology is commonly used to manufacture Inconel 625 seamless pipes. However pipe bursting may occur during the hot extrusion and recent studies have reported that stress distribution during hot extrusion is the main factor affecting the pipe bursting of Inconel 625 alloy. To solve the pipe bursting problem, this experiment aims to in-situ measure 3D stress distribution in Inconel 625 alloy during compression at room temperature.
DOI: 10.5286/isis.e.rb1920349
title: Interaction of an antimicrobial peptide from Lactobacillus gasseri supernatant with lipid bilayers mimicking the bacterial outer membrane

description: A short peptide, composed of 12 amino acids (EFVFVAHAVPVM), presenting a strongly hydrophobic character, was recently isolated from Lactobacillus gasseri supernatant (AMP12). This peptide has shown antimicrobial activity and may also bind the TLR4 receptor or lipopolysaccharides (LPS), which can result in blocking the activation of the inflammatory pathway. AMP12 was also hypothesized to penetrate into the cell given its small size and its character strongly hydrophobic. We are interested in the characterization of the interaction between AMP12 and lipid bilayers as mimics of the bacterial membrane. NR measurements can provide unique information on the mechanism of action of AMP12. We propose to characterize asymmetric lipid bilayers containing LPS from Escherichia Coli to investigate the location of AMP12 with respect to the bilayer.