cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6213614.v3
title: An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio

description: Despite availability of a diverse range of anti-epileptic drugs (AEDs), only about two-thirds of epilepsy patients respond well to drug treatment. Thus, novel targets are required to catalyse the design of next-generation AEDs. Manipulation of neuron firing-rate homoeostasis, through enhancing Pumilio (Pum) activity, has been shown to be potently anticonvulsant in <i>Drosophila</i>. In this study, we performed a genome-wide RNAi screen in S2R + cells, using a luciferase-based dPum activity reporter and identified 1166 genes involved in dPum regulation. Of these genes, we focused on 699 genes that, on knock-down, potentiate dPum activity/expression. Of this subgroup, 101 genes are activity-dependent based on comparison with genes previously identified as activity-dependent by RNA-sequencing. Functional cluster analysis shows these genes are enriched in pathways involved in DNA damage, regulation of cell cycle and proteasomal protein catabolism. To test for anticonvulsant activity, we utilised an RNA-interference approach <i>in vivo</i>. RNAi-mediated knockdown showed that 57/101 genes (61%) are sufficient to significantly reduce seizure duration in the characterized seizure mutant, <i>para<sup>bss</sup></i>. We further show that chemical inhibitors of protein products of some of the genes targeted are similarly anticonvulsant. Finally, to establish whether the anticonvulsant activity of identified compounds results from increased <i>dpum</i> transcription, we performed a luciferase-based assay to monitor <i>dpum</i> promoter activity. Third instar larvae exposed to sodium fluoride, gemcitabine, metformin, bestatin, WP1066 or valproic acid all showed increased <i>dpum</i> promoter activity. Thus, this study validates Pum as a favourable target for AED design and, moreover, identifies a number of lead compounds capable of increasing the expression of this homeostatic regulator.
DOI: 10.6084/m9.figshare.6211193
title: Change in GDP across the Eurozone

description: Sourced from Eurostat, the 2016 and 2017 GDP figures in Euros.
DOI: 10.6084/m9.figshare.6211193.v1
title: Change in GDP across the Eurozone

description: Sourced from Eurostat, the 2016 and 2017 GDP figures in Euros.
DOI: 10.6084/m9.figshare.6211139
title: Genomic Islands in strain B1

description: Putative genomic islands (GEIs) predicted within the genome of <i>Pseudomonas </i>sp. strain B1 when aligned against Pseudomonas putida KT2440 chromosome as the reference genomes. The outer black circle represents the scale line in Mbps and the black zig-zag line plot delineates each of the 48 contigs from strain B1. GEIs obtained from each of the following methods are shown in color: SIGI-HMM (orange), IslandPath-DIMOB (blue), and integrated detection (red), respectively.
DOI: 10.6084/m9.figshare.6211082
title: Marmorkrebs headlines

description: This spreadsheet compiles as many online articles that appeared following the publication of the following research article about marbled crayfish.<br><br>Gutekunst J, Andriantsoa R, Falckenhayn C, Hanna K, Stein W, Rasamy J, Lyko F. 2018. Clonal genome evolution and rapid invasive spread of the marbled crayfish. <i>Nature Ecology & Evolution</i> <b>2</b>: 567–573. https://doi.org/10.1038/s41559-018-0467-9.<br><br>
DOI: 10.6084/m9.figshare.6211082.v1
title: Marmorkrebs headlines

description: This spreadsheet compiles as many online articles that appeared following the publication of the following research article about marbled crayfish.<br><br>Gutekunst J, Andriantsoa R, Falckenhayn C, Hanna K, Stein W, Rasamy J, Lyko F. 2018. Clonal genome evolution and rapid invasive spread of the marbled crayfish. <i>Nature Ecology & Evolution</i> <b>2</b>: 567–573. https://doi.org/10.1038/s41559-018-0467-9.<br><br>
DOI: 10.6084/m9.figshare.6211076
title: Biomarkers for Alzheimer’s Disease and Related Disorders

description: <b>Article full text</b> <br> The articles within this thematic series can be found here. https://link.springer.com/journal/40120/6/1/suppl/page/1 <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6211076.v1
title: Biomarkers for Alzheimer’s Disease and Related Disorders

description: <b>Article full text</b> <br> The articles within this thematic series can be found here. https://link.springer.com/journal/40120/6/1/suppl/page/1 <br> <b>Provide enhanced content for this article</b> <br> If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <b>adisrapidplus@springer.com</b>. <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. <br> Other enhanced features include, but are not limited to: <br> • Slide decks • Videos and animations • Audio abstracts • Audio slides
DOI: 10.6084/m9.figshare.6211055
title: Retrieval cues and syntactic ambiguity resolution: speed-accuracy tradeoff evidence

description: Language comprehension involves coping with ambiguity and recovering from misanalysis. Syntactic ambiguity resolution is associated with increased reading times, a classic finding that has shaped theories of sentence processing. However, reaction times conflate the time it takes a process to complete with the quality of the behavior-related information available to the system. We therefore used the speed-accuracy tradeoff procedure (SAT) to derive orthogonal estimates of processing time and interpretation accuracy, and tested whether stronger retrieval cues (via semantic relatedness: neighed-&gt;horse vs. fell-&gt;horse) aid interpretation during recovery. On average, ambiguous sentences took 250ms longer (SAT rate) to interpret than unambiguous controls, demonstrating veridical differences in processing time. Retrieval cues more strongly related to the true subject always increased accuracy, regardless of ambiguity. These findings are consistent with a language processing architecture where cue-driven operations give rise to interpretation, and wherein diagnostic cues aid retrieval, regardless of parsing difficulty or structural uncertainty.
DOI: 10.6084/m9.figshare.6211055.v1
title: Retrieval cues and syntactic ambiguity resolution: speed-accuracy tradeoff evidence

description: Language comprehension involves coping with ambiguity and recovering from misanalysis. Syntactic ambiguity resolution is associated with increased reading times, a classic finding that has shaped theories of sentence processing. However, reaction times conflate the time it takes a process to complete with the quality of the behavior-related information available to the system. We therefore used the speed-accuracy tradeoff procedure (SAT) to derive orthogonal estimates of processing time and interpretation accuracy, and tested whether stronger retrieval cues (via semantic relatedness: neighed-&gt;horse vs. fell-&gt;horse) aid interpretation during recovery. On average, ambiguous sentences took 250ms longer (SAT rate) to interpret than unambiguous controls, demonstrating veridical differences in processing time. Retrieval cues more strongly related to the true subject always increased accuracy, regardless of ambiguity. These findings are consistent with a language processing architecture where cue-driven operations give rise to interpretation, and wherein diagnostic cues aid retrieval, regardless of parsing difficulty or structural uncertainty.
DOI: 10.6084/m9.figshare.6210872.v1
title: Information content of global ecosystem service databases and their suitability for decision advice – data repository

description: The concept of ecosystem services (ES) is attracting increased attention as a way to communicate the value of nature for human well-being by using a language that reflects dominant political and economic views. Progress in ES research has been rapid (Guerry et al. 2015), and there is an increasing information demand for diverse groups of decision makers (Schaefer et al. 2015; Bouwma et al. 2017). Incorporating ES information into decision making, however, is a long-term project and requires successfully addressing a number of challenges. One challenge is to efficiently exploit available information sources for decision advice. In Schmidt and Seppelt (2018) we reviewed how information contained in ES databases can support policy instruments to better take nature’s benefits into account. Here the data compiled within Schmidt and Seppelt (2018) was made available. In total 29 databases with global coverage were reviewed that contain information of 36,014 studies, projects and methods within more than 600,000 entries. Additionally, I identified 93 indicators of information demand for six major policy instruments which deal with or are directly related to the use of natural resources or land. Database entries were than matched with indicators of information demand. The resulting dataset encompasses the total number of data entries of ES databases that could be thematically linked to information requirements from indicators of information demand. Also, data was made available that provides broader insights into the content, design and impact of reviewed ES databases. Facilitating data discovery and linking ES databases with policy instruments are essential steps for the incorporation of ES information into decision making. <br>
DOI: 10.6084/m9.figshare.6210764
title: FIGA.tif

description: Transthoracic echocardiography. Please note the right to left shunt. Measured PAH was 72mmHg.
DOI: 10.6084/m9.figshare.6210764.v2
title: FIGA.tif

description: Transthoracic echocardiography. Please note the right to left shunt. Measured PAH was 72mmHg.
DOI: 10.6084/m9.figshare.6210506
title: Spreadsheets to calculate <i>P–V–T</i> relations, thermodynamic and thermoelastic properties of silicates in the MgSiO<sub>3</sub>–MgO system

description: Modified equations of state (EoS) of forsterite, wadsleyite, ringwoodite, akimotoite, bridgmanite and post-perovskite based on the Helmholtz free energy are described using Microsoft Excel spreadsheets. The equations of state were set up by joint analysis of reference experimental data and can be used to calculate thermodynamic and thermoelastic parameters and <i>P–V–T</i> properties of the Mg-silicates. We used Visual Basic for Applications module in Microsoft Excel and presented a simultaneous calculation of full set of thermodynamic and thermoelastic functions using only <i>T–P</i> and <i>T–V</i> data as input parameters. Phase transitions in the MgSiO<sub>3</sub>–MgO system play an important role in the interpretation of the seismic boundaries of the upper Earth’s mantle and in the D″ layer. Therefore, proposed EoSes of silicates in the MgSiO<sub>3</sub>–MgO system have clear geophysical implications. The developed software will be interesting to specialists who are engaged to study the mantle mineralogy and Earth’s interior.
DOI: 10.6084/m9.figshare.6210506.v2
title: Spreadsheets to calculate <i>P–V–T</i> relations, thermodynamic and thermoelastic properties of silicates in the MgSiO<sub>3</sub>–MgO system

description: Modified equations of state (EoS) of forsterite, wadsleyite, ringwoodite, akimotoite, bridgmanite and post-perovskite based on the Helmholtz free energy are described using Microsoft Excel spreadsheets. The equations of state were set up by joint analysis of reference experimental data and can be used to calculate thermodynamic and thermoelastic parameters and <i>P–V–T</i> properties of the Mg-silicates. We used Visual Basic for Applications module in Microsoft Excel and presented a simultaneous calculation of full set of thermodynamic and thermoelastic functions using only <i>T–P</i> and <i>T–V</i> data as input parameters. Phase transitions in the MgSiO<sub>3</sub>–MgO system play an important role in the interpretation of the seismic boundaries of the upper Earth’s mantle and in the D″ layer. Therefore, proposed EoSes of silicates in the MgSiO<sub>3</sub>–MgO system have clear geophysical implications. The developed software will be interesting to specialists who are engaged to study the mantle mineralogy and Earth’s interior.
DOI: 10.6084/m9.figshare.6210506.v1
title: Spreadsheets to calculate <i>P–V–T</i> relations, thermodynamic and thermoelastic properties of silicates in the MgSiO<sub>3</sub>–MgO system

description: Modified equations of state (EoS) of forsterite, wadsleyite, ringwoodite, akimotoite, bridgmanite and post-perovskite based on the Helmholtz free energy are described using Microsoft Excel spreadsheets. The equations of state were set up by joint analysis of reference experimental data and can be used to calculate thermodynamic and thermoelastic parameters and <i>P–V–T</i> properties of the Mg-silicates. We used Visual Basic for Applications module in Microsoft Excel and presented a simultaneous calculation of full set of thermodynamic and thermoelastic functions using only <i>T–P</i> and <i>T–V</i> data as input parameters. Phase transitions in the MgSiO<sub>3</sub>–MgO system play an important role in the interpretation of the seismic boundaries of the upper Earth’s mantle and in the D″ layer. Therefore, proposed EoSes of silicates in the MgSiO<sub>3</sub>–MgO system have clear geophysical implications. The developed software will be interesting to specialists who are engaged to study the mantle mineralogy and Earth’s interior.
DOI: 10.6084/m9.figshare.6210422
title: 景观位置基本数据--田秋香.xlsx

description: Raw data of site description and key soil properties along a topographic transect with ridge, middle slope, lower slope and valley positions in a subtropical mountain forest of China.
DOI: 10.6084/m9.figshare.6210413
title: Supplementary data to Gola, Pastewka, Model. Simul. Mater. Sci. Eng. 26, 055006 (2018)

description: * EAM potential datafile for Gola, Pastewka, Model. Simul. Mater. Sci. Eng. 26, 055006 (2018)<br><br>* Results of nested-sampling calculations of Cu-Au phases for the following interatomic embedded-atom method potentials:<br>- Ackland, Vitek, Phys. Rev. B 41, 10324–10333 (1990)- Barrera, de Tendler, Isoardi, Model. Simul. Mater. Sci. Eng. 8 389 (2000) - Foiles, Baskes, Daw, Phys. Rev. B 33 7983–7991(1986) - Gola, Pastewka, Model. Simul. Mater. Sci. Eng., in press (2018)- Zhou, Johnson, Wadley, Phys. Rev. B 69 144113 (2004)
DOI: 10.6084/m9.figshare.6210392
title: Increasing the detail of land use/cover data for Europe by combining heterogeneous data sets

description: Data on land use and land cover (LULC) are a vital input for policy-relevant research, such as modelling of the human population, socioeconomic activities, transportation, environment, and their interactions. In Europe, CORINE Land Cover has been the only data set covering the entire continent consistently, but with rather limited spatial detail. Other data sets have provided much better detail, but either have covered only a fraction of Europe (e.g. Urban Atlas) or have been thematically restricted (e.g. Copernicus High Resolution Layers). In this study, we processed and combined diverse LULC data to create a harmonised, ready-to-use map covering 41 countries. By doing so, we increased the spatial detail (from 25 to one hectare) and the thematic detail (by seven additional LULC classes) compared to the CORINE Land Cover. Importantly, we decomposed the class ‘Industrial and commercial units’ into ‘Production facilities’, ‘Commercial/service facilities’ and ‘Public facilities’ using machine learning to exploit a large database of points of interest. The overall accuracy of this thematic breakdown was 74%, despite the confusion between the production and commercial land uses, often attributable to noisy training data or mixed land uses. Lessons learnt from this exercise are discussed, and further research direction is proposed.
DOI: 10.6084/m9.figshare.6210389.v1
title: Nano-composites Inhibit the Formation, Mitigate the Neurotoxicity and Facilitate the Removal of β-amyloid Aggregates in Alzheimer's Disease Mice

description: Alzheimer’s disease (AD) is defined as an insidious and fatal<i> </i>aging-associated neurodegenerative disorder associated with progressive memory loss and cognitive decline<i>.</i> Among over one hundred attempts to treat these symptoms, despite certain degrees in symptomatic improvement, however, they still failed to reverse or even delay the progressive deterioration in cognitive capability, agitation, depression or psychosis. Recent studies revealed the pivotal role of β-amyloid (Aβ) in AD. The assembly of Aβ into pathological seeds, including toxic oligomers and their subsequent aggregates, constitutes the primary neuropathological hallmark. Unfortunately, there was no clear indication that current nanomaterials exerted any effect on mitigation of Aβ-induced neurotoxicity and elimination of Aβ aggregates <i>in vivo</i>. Therefore, an effective AD therapy requires the development of new therapeutic agents that can modulate Aβ aggregations to reduce the amount of Aβ oligomers and fibrils, as well as accelerate elimination to restore Aβ balance in patient’s brain.
DOI: 10.6084/m9.figshare.6210389.v2
title: Nano-composites Inhibit the Formation, Mitigate the Neurotoxicity and Facilitate the Removal of β-amyloid Aggregates in Alzheimer's Disease Mice

description: Alzheimer’s disease (AD) is defined as an insidious and fatal<i> </i>aging-associated neurodegenerative disorder associated with progressive memory loss and cognitive decline<i>.</i> Among over one hundred attempts to treat these symptoms, despite certain degrees in symptomatic improvement, however, they still failed to reverse or even delay the progressive deterioration in cognitive capability, agitation, depression or psychosis. Recent studies revealed the pivotal role of β-amyloid (Aβ) in AD. The assembly of Aβ into pathological seeds, including toxic oligomers and their subsequent aggregates, constitutes the primary neuropathological hallmark. Unfortunately, there was no clear indication that current nanomaterials exerted any effect on mitigation of Aβ-induced neurotoxicity and elimination of Aβ aggregates <i>in vivo</i>. Therefore, an effective AD therapy requires the development of new therapeutic agents that can modulate Aβ aggregations to reduce the amount of Aβ oligomers and fibrils, as well as accelerate elimination to restore Aβ balance in patient’s brain.
DOI: 10.6084/m9.figshare.6210359
title: cotorras_pedigree.txt

description: Dataset with pedigree information from monk parakeets.
DOI: 10.6084/m9.figshare.6210359.v1
title: cotorras_pedigree.txt

description: Dataset with pedigree information from monk parakeets.
DOI: 10.6084/m9.figshare.6210305
title: Supplementary Material for: High Amount of Organic Matter during Caries Formation Reduces Remineralization and Resin Infiltration of Enamel Caries

description: The amount of organic material in the cariogenic environment correlates with the amount of organic material incorporated in carious enamel. The incorporated organic material may be expected to reduce the pore volumes available for remineralization and resin infiltration, but these expected outcomes have not yet been quantified. We tested the effect of the amount of organic content in the cariogenic agent on remineralization and the resin-occluded pore volume in artificial subsurface enamel caries. An acid gel (organic-rich; G1) and an aqueous solution (organic-poor; G2) were used to induce subsurface lesions in human enamel. Undemineralized histological sections were prepared, microradiographed, and then submitted to resin infiltration in vitro. The enamel component volumes (mineral, organic, remineralizable [total water volume], loosely and firmly bound water volumes, and resin-occluded volume) were measured (by microradiography and polarizing microscopy) at histological sites (<i>n</i> = 38, G1; <i>n</i> = 34, G2). The main outcomes were the differences between the experimental and the predicted volumes (Δremineralizable and Δresin-occluded volumes). Resin infiltration was confirmed by confocal scanning laser microscopy. Compared to G2, G1 presented more incorporated organic volume and lower Δremineralizable volume (<i>p</i> = 0.003; Hedges <i>g</i> = 0.66; power = 0.87), a lower increase in loosely bound water volume (<i>p</i> = 0.0013; Hedges <i>g</i> = 0.74; power = 0.93), a lower remineralization volume in the surface layer (<i>p</i> = 0.017; Hedges <i>g</i> = 0.68; power = 0.8), and a lower Δresin-occluded volume (<i>p</i> = 0.0015; Hedges <i>g</i> = 0.73; power = 0.92). In conclusion, the higher amount of organic matter in the cariogenic gel negatively affected remineralization and the resin-occluded volume in subsurface lesions.