cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29163185.v1
title: Supplementary Material for: Trajectory patterns of metabolic syndrome severity score and risk of chronic kidney diseases

description: Background: Despite the reported connection between different combinations of the standard MetS criteria and chronic kidney diseases (CKD), most data raise significant concerns about its predictive usefulness in clinical settings beyond its components. Metabolic syndrome severity, expressed by the continuous metabolic syndrome severity score(cMetS-S), is a more applicable health metric that may more accurately predict future health outcomes. However, no evidence is known about the association between the trajectory of cMetS-S and the development of CKD.
Method: In the population-based Tehran Lipid and Glucose Study, 4462 participants aged 20-60 years free of CKD at baseline were included and followed at three-year intervals. We examined the trajectories of cMetS-S over nine years using latent growth mixture modeling (LGMM) and subsequent risks of incident CKD eight years later. The prospective association of identified trajectories with CKD was examined using the Cox proportional hazard model adjusting for age, sex, education, and family history of diabetes, physical activity, obesity (BMI ≥ 30 kg/m2), antihypertensive and lipid-lowering medication, and baseline fasting plasma glucose in a stepwise manner.
 Results: Three cMetS-S trajectory groups of low (28.3 %), medium (50.0%), and high (21.7 %) were identified during the exposure period. High cMetS-S trajectory pattern was associated with increased risk of CKD adjusting for age, sex, education, smoking, physical activity, baseline eGFR, and even after further adjustment for MetS components (1.32; 95%CI: 1.04-1.67). The associated risk remained significant even in normoglycemic, non-obese, and non-hypertensive individuals. Sex-specific subgroup analysis showed that Mets severity score is associated with CKD only in men.
Conclusion: The trend of cMetS-S over time is associated with the development of CKD, even in those without major risk factors, e.g., obesity, diabetes mellitus, and hypertension. It could be clinically helpful in identifying individuals at elevated risk rather than stating it as a predictive or causative factor. It could be clinically beneficial in identifying and tracking individuals at elevated risk rather than stating it as a predictive or causative factor.
DOI: 10.17632/3c8k85j8hn
title: Madrasa student’s health-related quality of life and its associated factors: A cross-sectional study from Bangladesh

description: The evidence clearly shows that education greatly impacts people’s well-being. Bangladesh has two main education systems—general and traditional religious schooling. The current study aimed to measure madrasa students' quality of life and determine the factors influencing it. This was a cross-sectional study on a group of madrasa students in the Mirpur area of Dhaka, Bangladesh. Data were collected using two-stage stratified random sampling between April and May 2022. The final sample size was 373. The health-related quality of life (HRQoL) was calculated using the KIDSCREEN-10 index, and the median split was used to categorize the score into ‘good’ and ‘poor’ categories. A p &lt; 0.05 was considered statistically significant for all statistical tests. Among the participants, most (56%) reported having a good HRQoL. The median age (IQR) of the participants was 10.0 (8.0–12.0) years. Most of the participants were male (91%) and were not orphans (95%). The current study also found that a higher feeling of safety (AOR 3.7; 95% CI 1.3–10.4; p = 0.016) increased the odds of having good HRQoL. However, having a present illness decreased the odds (AOR 0.6; 95% CI 0.4–0.9; p = 0.10) of having a good HRQoL. The key results show that the majority reported a good HRQoL. Promoting students’ physical, mental, and social well-being through health education, anti-bullying initiatives, regular school health screening, and institutional & community involvement can help to improve the overall HRQoL of madrasa students.
DOI: 10.6084/m9.figshare.15081510.v1
title: Data and code for "Contrasting impacts of forests on cloud cover based on satellite observations"

description: This repository contains Code and Data for "Contrasting impacts of forests on cloud cover based on satellite observations" by Xu et al 2021 (currently under review).<br>For detailed description, please refer to file "README.md".<br>Contact: Yan Li (yanli.geo@gmail.com)
DOI: 10.6084/m9.figshare.17080739.v1
title: Supplementary Material for: <b><i>Porphyromonas gingivalis</i></b> Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells

description: Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is constitutively produced by endothelial cells and plays a vital role in maintaining vascular homeostasis. Chronic periodontitis is an inflammatory disease characterized by bleeding of periodontal tissues that support the tooth. In this study, we aimed to determine the role of PAI-1 produced by endothelial cells in response to infections caused by the primary periodontal pathogen <i>Porphyromonas gingivalis</i>. We demonstrated that <i>P. gingivalis</i> infection resulted in significantly reduced PAI-1 levels in human endothelial cells. This reduction in PAI-1 levels could be attributed to the proteolysis of PAI-1 by <i>P. gingivalis</i> proteinases, especially lysine-specific gingipain-K (Kgp). We demonstrated the roles of these degradative enzymes in the endothelial cells using a Kgp-specific inhibitor and <i>P. gingivalis</i> gingipain-null mutants, in which the lack of the proteinases resulted in the absence of PAI-1 degradation. The degradation of PAI-1 by <i>P. gingivalis</i> induced a delayed wound healing response in endothelial cell layers via the low-density lipoprotein receptor-related protein. Our results collectively suggested that the proteolysis of PAI-1 in endothelial cells by gingipains of <i>P. gingivalis</i> might lead to the deregulation of endothelial homeostasis, thereby contributing to the permeabilization and dysfunction of the vascular endothelial barrier.
DOI: 10.6084/m9.figshare.5120425.v1
title: Supplementary Material for: Identification of Genes Targeted by CpG Island Methylator Phenotype in Neuroblastomas, and Their Possible Integrative Involvement in Poor Prognosis

description: <i>Background/Aims:</i> CpG island (CGI) methylator phenotype (CIMP) is strongly associated with poor prognosis in neuroblastomas (NBLs; hazard ratios 7–22). Methylation of nonpromoter CGIs is useful to detect the presence of the CIMP, while the poor prognosis is considered to be caused by gene silencing due to promoter methylation. Here, promoter CGIs targeted by the CIMP were searched for. <i>Methods:</i> A genome-wide screening was performed by methylation-sensitive representational difference analysis of CIMP(+) and CIMP(–) NBLs. <i>Results:</i> Promoter CGIs of 9 genes were methylated in CIMP(+) NBL cell lines and caused silencing of their downstream genes. On analysis of 90 clinical specimens, <i>CYP26C1,</i><i>FERD3L </i>(<i>N-TWIST</i>), <i>CRYBA2</i> and <i>PCDHGC4 </i>were methylated at significantly higher incidences in CIMP(+) NBLs than CIMP(–) NBLs, while the difference was unclear for <i>NPY</i>, <i>SPAG6</i>, <i>DDIT4L</i>, <i>CHR3SYT</i> and <i>C6Orf141</i>. Methylation of <i>CYP26C1 </i>and <i>FERD3L</i> was significantly associated with poor prognosis, but weaker than the presence of the CIMP. Treatment of an NBL cell line with a demethylating agent caused demethylation of multiple promoter CGIs, and enhanced 13-<i>cis</i>-retinoic acid-induced neuronal differentiation. <i>Conclusion:</i> Our results indicate that the CIMP causes poor prognosis of NBLs by inducing methylation of multiple promoter CGIs with various incidences.
DOI: 10.17632/xv624h2kxj
title: Meta-analysis PF-PI and SUDs

description: Review question: What evidence is there of an association between substance addiction, abuse, or misuse and psychological flexibility or inflexibility and their components (acceptance, contact with the present moment, self as context, defusion, committed action, contact with values, experiential avoidance, lack of contact with the present moment, self as content, cognitive fusion, inaction, lack of contact with values). 
Results: positive association between experiential avoidance and substance abuse. Negative association between mindfulness (contact with the present moment) and substance abuse. Only one study reported a positive association between defusion and substance abuse.
The files provide the coding protocol, the data extracted to conduct the meta-analysis and moderator analysis, and the assessment of quality of the studies included.
DOI: 10.17632/y4hph4cr22
title: Data for: Ascertaining glacier dynamics and geodetic mass changes in the Pangong Region of Trans-Himalayan Ladakh using remote sensing data 

description: The data attached with this article is related to the glacier recession, frontal retreat, physiographic characterization of glaciers, glacier-wise geodetic mass changes, potential glacier bed overdeepening vis-à-vis proglacial lake evolution, and comparison of existing glacier inventories in the Pangong Region of Trans-Himalayan Ladakh, India. A paper pertaining to this analysis already stands published in Frontiers in Earth Science [https://doi.org/10.3389/feart.2021.748107].

The RAR file contains data pertaining to the following aspects of glacier recession in the Pangong Region:
1. Glacier-wise characteristics 
2. Glacier outlines of 1990 and 2019
3. Glacier outlines of existing glacier inventories and this study
4. Glacier-wise geodetic mass changes
5. GlabTop model input and output
DOI: 10.6084/m9.figshare.21907557.v1
title: EV energy Demand Forecasting

description: The dataset comprises EV energy demand focasting
DOI: 10.6084/m9.figshare.24415549.v1
title: This Month in GLAM Newsletter: full text (2011-2023), views, and regions

description: This tsv contains the result of all This Month in GLAM reports from 2011 to March 2023.All URLs were retrieved using the Query in Quarry: https://quarry.wmcloud.org/query/72725Regions, years and months were extracted from the URLs using R.Full text was scraped using python and a custom functionThe museum check was done, looking for content that would match the following regex: "[M|m]use*|[G|g]aller*". The libraries check was derived from the search of this other pattern: "[L|l]ibrar.*|[B|b]ibliot.*"Pageviews were retrieved using the Massviews tool and pairing the results with the existing databaseThe DOI to this dataset is: 10.6084/m9.figshare.24415549
DOI: 10.6084/m9.figshare.26495722.v1
title: <b>A rationale for chemical defense mixtures in spruce oleoresin: most monoterpenes are highly toxic to either bark beetles or to their symbiotic fungi, but not both</b>

description: Monoterpenes in conifer oleoresin frequently occur as complex blends of 15-30 components, but the underlying ecological reasons for these mixtures are not yet known. We tested the toxicity of 12 individual Norway spruce monoterpenes and their mixtures to adult Eurasian spruce bark beetles, <i>Ips typographus,</i> and three major symbiotic fungi in the vapor phase. Individual monoterpenes had generally opposite effects on bark beetles compared to symbiotic fungi, with the compounds most toxic to beetles being the least inhibitory to fungal growth and <i>vice versa</i>. These results support the interaction diversity hypothesis, which posits that defense mixtures are maintained because the individual components target different attackers. Among the symbiotic fungi tested, one (<i>Grosmannia penicillata</i>) exhibited high tolerance to monoterpenes, and its growth was even stimulated by the monoterpenes most toxic to the beetle. Interestingly, spruce bark responds to <i>G. penicillata</i> inoculation by accumulating higher concentrations of specifically fungistatic monoterpenes.
DOI: 10.6084/m9.figshare.27852663.v1
title: Supplementary Material for: Pre-Stroke Frailty Negatively Affects Leptomeningeal Collateral Flow in Proximal Middle Cerebral Artery Occlusion

description: Introduction: The adequacy of blood flow from the leptomeningeal collaterals is considered one of the most important factors determining the rate of infarct progression and response to acute stroke treatments in the setting of large vessel occlusions. Several patient-related variables, including age, vascular risk factors, and laboratory parameters, have been proposed to explain the interindividual variability of collateral flow among stroke patients. This study aimed to assess how pre-stroke frailty, an aging-related syndrome characterized by a loss in the physiologic reserve of numerous body functions, affected the degree of leptomeningeal collateral flow in the setting of acute ischemic stroke.
Methods: A consecutive series of patients presenting with proximal middle cerebral artery occlusion were enrolled in this prospective, multi-center observational study. Collateral flow was determined by the Regional Leptomeningeal Collateral (rLMC) Score on admission computed tomography angiography images. Pre-stroke frailty was assessed by the Edmonton Frailty Scale (EFS), based on the information obtained from patients or their next of kin. The relationship between collateral flow and frailty was evaluated by bivariate and multivariate analyses taking into consideration the demographic, clinical and imaging characteristics of the patients. 
Results: The study population was comprised of 116 patients (median (IQR) age 78 (71-84) years; 60% female). The EFS scores were negatively correlated with the rLMC score (r=-0.264; p=0.004). A vulnerable or frail (EFS≥6) status before stroke, higher blood pressure levels at admission, having imaging studies performed at an earlier phase after contrast injection, and presenting with thrombi extending to the proximal half of the M1 portion of the middle cerebral artery were significantly related to poor collateral circulation (rLMC score ≤10). After adjustment for potential confounders in multivariable analyses, a vulnerable/frail status was independently associated with poor leptomeningeal collateral flow [OR 2.97 (95%CI 1.15-7.69); p=0.025].
Conclusion: Our findings highlight that the leptomeningeal collateral flow is also compromised as part of the diminished physiologic reserve characterizing the frailty status in patients with acute ischemic stroke. Future studies are needed to understand how this interplay contributes to the unfavorable clinical outcomes observed in frail patients after stroke.
DOI: 10.6084/m9.figshare.28513046.v1
title: <b>Экстракорпоральная детоксикация при абдоминальном септическом шоке с острым повреждением почек: проспективное интервенционное контролируемое исследование</b><b>(часть </b><b>II</b><b>)</b>

description: <b>Актуальность.</b> Выбор тактики экстракорпоральной детоксикации (ЭКД) при септическом шоке (СШ) и остром повреждении почек (ОПП) остается нерешенной проблемой.<b>Цель исследования.</b> Оценить тяжесть состояния и клинические исходы при различных подходах к применению ЭКД.<b>Материалы и методы.</b> <b>Группа 1 (n=34):</b> применение вено-венозной гемодиафильтрации (ПВВГДФ) по неотложным показаниям. <b>Группа 2 (n=35):</b> ранняя изолированная ПВВГДФ. <b>Группа 3 (n=32):</b> комбинированная ЭКД (селективная плазмафильтрация (СПФ) и ПВВГДФ). Проведен сравнительный анализ клинико-лабораторных показателей.<b>Результаты.</b> Комбинированная ЭКД в составе интенсивной терапии: стабилизирует среднее артериальное давление к 2-м суткам (<i>р</i>=0,015); сокращает длительность вазопрессорной поддержки на 40,4% по сравнению с группой 1 (<i>р</i>=0,003); достоверно снижает тяжесть органной дисфункции по шкале SOFA к 3-м суткам терапии (<i>р</i>=0,001); сокращает длительность пребывания в ОРИТ на 50% по сравнению с группой 1 (с 21 до 10,5 дней, <i>р</i>=0,0002); сокращает длительность пребывания в стационаре на 23,6% по сравнению с группой 1 (с 27,5 до 21 дня, <i>р</i>=0,0001); выживаемость в группе составила 71,9%, по сравнению с группой 1 – 41,2% (<i>р</i>=0,015) и группой 2 – 57,1% (<i>р</i>=0,308).<b>Выводы.</b> Включение комбинированной ЭКД в состав комплексной интенсивной терапии позволяет добиться скорейшей стабилизации гемодинамики, сократить длительность вазопрессорной поддержки, улучшить общее состояние пациентов и улучшить клинические исходы заболевания.
DOI: 10.6084/m9.figshare.7742732.v1
title: GISS ModelE 150 Tg US-Russia

description: 150 Tg injection of black carbon over US and Russia using GISS ModelE
DOI: 10.17632/drbzbd8jw9
title: Reverse Blending, an intelligent design and production tool for continuous mass customization

description: Industrial revolution 4.0 has obtained great success in discrete production (objects...) by de- laying customization in units of production or assembly. Continuous production (granules, liquids...) is the forgotten part of this revolution due to the organization of production based on sequencing batches of different products, which makes challenging the efficient production of a wide variety of products. In response to this, a new product design and manufacturing approach, called Reverse Blending, is proposed to postpone the customization of fertilizers in small blending units implemented close to the final customer. This approach is based on searching for the optimal chemical composition of a reduced number of semi-finished common products whose possible combinations may satisfy a very large variety of customized finished products. This approach allows fertilizer producers - who aim to promote sustainable agriculture by delivering customized products - to make their supply chains smart and sustainable. Its potential is demonstrated through four case studies.
DOI: 10.23641/asha.7336055.v1
title: Lexicality and intensity in speech intervention (Cummings et al., 2018)

description: <b>Purpose: </b>This study examined how lexical representations and intervention intensity affect phonological acquisition and generalization in children with speech sound disorders.<b>Method:</b> Using a single-subject multiple baseline design, 24 children with speech sound disorders (3;6 to 6;10 [years;months]) were split into 3 word lexicality types targeting word-initial complex singleton phonemes: /ɹ l ʧ θ/. Specifically, academic vocabulary words, nonwords (NWs), and high-frequency (HF) words were contrasted. Intervention intensity was examined by comparing the performance of 12 children who completed eleven 50-min sessions (4 children/word type) to the performance of 12 who completed 19 sessions (4 children/word type). Children’s production accuracy of their treated phonemes and overall percent consonants correct values were used to measure phonological generalization via percentage accuracy scores and d scores. <b>Results:</b> All word lexicality conditions elicited phonological change, suggesting that academic vocabulary words, NWs, and HF words are viable intervention targets. Group mean averages were similarly high for the NWs and HF words, although children in the NW condition demonstrated more consistent phonological gains. Children who received 19 intervention sessions achieved 6 times more gains in treated sound accuracy than did children who received 11 sessions.<b>Conclusions: </b>Word lexicality did not significantly influence children’s intervention outcomes. More intensive intervention, as characterized by the number sessions, resulted in greater phonological change than did a shorter intervention program. Intervention intensity outcomes should be considered when establishing best practices for speech intervention scheduling.<br><b>Supplemental Material S1. </b>Neighborhood density, phonotactic probability, Kučera and Francis (1967) word frequency (WF), log 10 WF, and age of acquisition (in years) measurements (AoA) for the academic vocabulary (AV) words.<br><b>Supplemental Material S2.</b> Neighborhood density and phonotactic probability measurements for the nonwords (NWs).<br><b>Supplemental Material S3. </b>Neighborhood density, phonotactic probability, Kučera and Francis (1967) word frequency (WF), log 10 WF, and age of acquisition (in years) measurements (AoA) for the high-frequency (HF) words.<br><b>Supplemental Material S4. </b>Intervention fidelity data sheet for Imitation phase.<br><b>Supplemental Material S5.</b> Intervention fidelity data sheet for Spontaneous Production phase.<br><b>Supplemental Material S6. </b>Number of intervention trials (i.e., treatment dose) for each session and all children. Gray boxes identify sessions included in the intervention fidelity assessment.<br>Cummings, A., Hallgrimson, J., & Robinson, S. (2018). Speech intervention outcomes associated with word lexicality and intervention intensity.<i> Language, Speech, and Hearing Services in Schools.</i> Advance online publication. https://doi.org/10.1044/2018_LSHSS-18-0026
DOI: 10.6084/m9.figshare.24062580.v1
title: Data and R Code from Granados et al. 2023, Mammalian predator and prey responses to recreation and land use across multiple scales provide limited support for the human shield hypothesis, Ecology and Evolution.

description: Data from Granados et al. 2023 Mammalian predator and prey responses to recreation and land use across multiple scales provide limited support for the human shield hypothesis, Ecology and Evolution
DOI: 10.6084/m9.figshare.25187558.v1
title: RawData_Simulations_Schmitz_etal.

description: This file contains simulation data used in Schmitz et al. (2023) "Predicting bacterial interaction outcomes from monoculture growth and supernatant assays" available on bioRxiv.
DOI: 10.17632/knsrc2vwh3
title: Data for: A New South Polar Digital Terrain Model of Mars from the High Resolution Stereo Camera (HRSC) onboard the ESA Mars Express

description: HRSC Level 2 Product IDs used as Inputs to produce a New South Polar Digital Terrain Model of Mars
DOI: 10.17632/m96m82x938
title: Additional supplemental data Immunity paper: NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

description: Secondary only controls for western blot
(A) Microglia were primed with 100ng/ml LPS for 3 h, incubated with 1μM CRID3 or 100nM NP3-361 for 30 min and 5μM Aβ for 24 h. The lysates or (B) supernatants were prepared for immunoblot, and incubated with secondary only antibodies: goat anti-mouse 800 (used for NLRP3), goat anti-rabbit 680 (used for IL-1β) and goat anti-rat 680 (used for caspase-1). (C) The cortex of 4-, 6- and 12-month-old wild-type, APP/PS1, NLRP3-/- and APP/PS1.NLRP3-/- mice was prepared for immunoblot, and probed with secondary antibodies only. (D) Immunoblot analysis of secondary only controls from the cortex of patients with AD and non-demented, age-matched controls.
DOI: 10.6084/m9.figshare.22686724.v1
title: ReQSI-CI - Catálogo de Requisitos Não-Funcionais para Sistemas de Informação em Cidades Inteligentes

description: Catálogo de Requisitos Não-Funcionais para Sistemas de Informação em Cidades Inteligentes
DOI: 10.6084/m9.figshare.7857707.v1
title: tar.gz file

description: .gz file for download testing<br>
DOI: 10.17632/545wb2gnd7
title: Associative Memory, Beliefs and Market Interactions

description: The files allow to replicate the results presented in our paper "Associative Memory, Beliefs and Market Interactions".

The second zip file adds a readme file to the STATA do-file and STATA datasets.