DOI: 10.5061/dryad.59zw3r27n
title: Telerehabilitation program for COVID-19 survivors (TERECO) - Randomized controlled trial

description: Objectives To investigate superiority of a telerehabilitation program for
 Covid-19 (TERECO) over no rehabilitation with regard to exercise capacity,
 lower-limb muscle strength (LMS), pulmonary function, health-related
 quality of life (HRQOL), and dyspnoea. Design Parallel-group randomised
 controlled-trial with 1:1 block-randomisation. Setting Three major
 hospitals from Jiangsu and Hubei provinces, China. Participants 120
 formerly hospitalised Covid-19 survivors with remaining dyspnoea
 complaints were randomised with 61 allocated to control and 59 to TERECO.
 Intervention Unsupervised home-based 6-week exercise program comprising
 breathing control and thoracic expansion, aerobic exercise, and LMS
 exercise, delivered via smartphone, and remotely monitored with heart rate
 telemetry. Outcomes Primary outcome was 6-minute walking distance (6MWD)
 in metres. Secondary outcomes were squat time in seconds; pulmonary
 function assessed by spirometry; HRQOL measured with SF-12; and
 mMRC-dyspnoea. Outcomes were assessed at 6 weeks (post-treatment) and 28
 weeks (follow-up). Results Adjusted between-group difference in change in
 6MWD was 65.45 metres (95% CI 43.8, 87.1; p&lt;0.001) at
 post-treatment and 68.62 metres (95% CI 46.39, 90.85; p&lt;0.001) at
 follow-up. Treatment effects for LMS were 20.12 seconds (95% CI 12.34,
 27.9; p&lt;0.001) post-treatment and 22.23 seconds (95% CI 14.24,
 30.21; p&lt;0.001) at follow-up. No group differences were found for
 lung function except post-treatment MVV. Increase in SF-12 physical
 component was greater in the TERECO group with treatment effects estimated
 as 3.79 (95% CI 1.24, 6.35; p=0.004) at post-treatment and 2.69 (95% CI
 0.06, 5.32; p=0.045) at follow-up. Conclusions This trial demonstrated
 superiority of TERECO over no rehabilitation for 6MWD, LMS, and physical
 HRQOL. Trial registration: ChiCTR2000031834, URL:
 http://www.chictr.org.cn/showproj.aspx?proj=52216
description: Data are from a multi-centre, parallel-group randomised
 controlled trial. The original protocol for this study is available from
 (URL: http://idmr.scu.edu.cn/info.htm?id=1841614474692833). This study was registered at the Chinese Clinical Trial Registry on 11 Apr 2020 (ChiCTR2000031834). Ethical approval was first received from the Institutional Review Board (IRB) of the First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital (2020-SR-171, 9 April 2020) and then subsequently from the IRBs of Hubei Province Hospital of Integrated Chinese and Western Medicine (2020016, 14 April 2020), and Huangshi Hospital of Chinese Medicine (HSZYPJ-2020-026-01, 20 April 2020). Three centres from Jiangsu (The First Affiliated Hospital of Nanjing Medical University), Hubei Wuhan (Hubei Province Hospital of Integrated Chinese and Western Medicine), and Hubei Huangshi (Hubei Huangshi Hospital of Chinese Medicine) collected data from 119 patients recovering from COVID-19 after discharge from one of the centres (60 assigned to control and 59 assigned to intervention). Data were collected between 26 April and 9 December 2020 at three time points: baseline, post-treatment assessment at 6 weeks and follow-up assessment at 28 weeks. Assessed outcomes included 6 minute walking distance, squat time in seconds, pulmonary function parameters (FEV1, FVC, FEV1/FVC, PEF, MVV), SF-12 medical outcomes short form, mMRC dyspnea (favorable outcome: being dyspnea-free). Adverse events were also recorded.
description: Two types of data sets are provided: outcome and descriptive
 patient data in wide format and adverse event data in long format. Data
 sets can be linked with an annymized patient ID. Both datasets are
 provided as Stata 14 files (labled) and csv files (unlabled). Each dataset
 has a corresponding codebook.