cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11353787.v1
title: Esmirtazapine treatment of postmenopausal vasomotor symptoms: two randomized controlled trials

description: <b>Objectives:</b> Two identical 12-week, randomized, double-blind, placebo-controlled, multi-arm, parallel-group Phase III studies (Study P012, NCT00560833; Study P013, NCT00535288) evaluated the efficacy and safety of esmirtazapine, an investigational medicine, for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women. <b>Methods:</b> Participants were randomized to placebo or esmirtazapine (2.25, 4.5, 9.0, or 18.0 mg). Co-primary efficacy endpoints (daily frequency and severity of moderate to severe VMS, both at weeks 4 and 12) were based on participative LogPad daily diaries. Adverse events (AEs) were recorded. <b>Results:</b> In Studies P012 and P013, 942 and 946 participants were randomized, respectively. Compared with placebo, esmirtazapine significantly reduced the mean daily frequency by 1.4–2.2 moderate to severe VMS at weeks 4 and 12 (both ≥4.5 mg) and mean daily severity by 0.06–0.08 symptoms at weeks 4 (≥4.5 mg) and 12 (9.0 mg P012; 18.0 mg P013 only). Esmirtazapine was generally well tolerated with a more favorable safety profile at lower doses. Somnolence and fatigue were the most frequently reported AEs. <b>Conclusions:</b> Esmirtazapine reduced the frequency and severity of moderate to severe VMS associated with menopause and was generally well tolerated in the study population.
DOI: 10.6084/m9.figshare.11353793.v1
title: Supplemental table 1.pdf

description: Baseline blood pressure of Hypertensive rat model induced by salt depletion
DOI: 10.6084/m9.figshare.11353775.v1
title: Supplementary Material for: High-Grade Progression Confers Poor Survival in Pancreatic Neuroendocrine Tumors

description: <b><i>Introduction:</i></b> Little is known about how pancreatic neuroendocrine tumors (PanNETs) evolve over time and if changes toward a more aggressive biology correlate with prognosis. The purpose of this study was to characterize changes in PanNET differentiation and proliferation over time and to correlate findings to overall survival (OS). <b><i>Patients and Methods:</i></b> In this retrospective cohort study, we screened 475 PanNET patients treated at Uppsala University Hospital, Sweden. Sporadic patients with baseline and follow-up tumor samples were included. Pathology reports and available tissue sections were reevaluated with regard to tumor histopathology and Ki-67 index. <b><i>Results:</i></b> Forty-six patients with 106 tumor samples (56 available for pathology reevaluation) were included. Median Ki-67 index at diagnosis was 7% (range 1–38%), grade 1 <i>n</i> = 8, grade 2 <i>n</i> = 36, and grade 3 <i>n</i> = 2. The median change in Ki-67 index (absolute value; follow-up – baseline) was +14% (range –11 to +80%). Increase in tumor grade occurred in 28 patients (63.6%), the majority from grade 1/2 to grade 3 (<i>n</i> = 24, 54.5%). The patients with a high-grade progression had a median OS of 50.2 months compared to 115.1 months in patients without such progression (hazard ratio 3.89, 95% CI 1.91–7.94, <i>p</i> &lt; 0.001). <b><i>Conclusions:</i></b> A longitudinal increase in Ki-67 index and increase in tumor grade were observed in a majority of PanNETs included in this study. We propose that increase in Ki-67 index and high-grade progression should be investigated further as important biomarkers in PanNET.
DOI: 10.6084/m9.figshare.11353799.v2
title: Differential metabolites of DM patients after CABG procedure.

description: Note: Metabolites between two groups were considered different when the p-value of the T test &lt; 0.05 and VIP ≥ 1. Abbreviations: CABG, Coronary artery bypass grafting; A, preoperative sample; B, postoperative sample; VIP, variable importance in projection.
DOI: 10.6084/m9.figshare.11353772
title: Supplementary Material for: Ventilated Infants Have Increased Dead Space and Lower Alveolar Tidal Volumes during the Early versus Recovery Phase of Respiratory Distress

description: <b><i>Background:</i></b> Few studies have reported the measurement of anatomical dead space (V<sub>d,an</sub>) and alveolar tidal volume (V<sub>A</sub>) in ventilated neonates with respiratory distress. <b><i>Objective:</i></b> The aim of this study was to determine the differences in V<sub>d,an</sub> and V<sub>A</sub> in ventilated infants between the early and recovery phases of respiratory distress using volumetric ­capnography (V<sub>cap</sub>) based on ventilator graphics and capnograms. <b><i>Methods:</i></b> This study enrolled twenty-five ventilated infants (mean birth weight, 2,220 ± 635 g; mean gestational age, 34.7 ± 3.3 weeks). We adjusted respiratory settings to maintain appropriate oxygenation and tidal volume (V<sub>T</sub>), and performed V<sub>cap</sub> based on waveforms of ventilator graphics and capnograms. V<sub>d,an</sub> and V<sub>A</sub>were measured in infants with respiratory disorders, immediately after intubation (early phase) and subsequently when they were clinically stable (recovery phase). <b><i>Results:</i></b> The early phase, with lower dynamic lung compliance, required a higher level of ventilator support, not positive end-expiratory pressure, than the recovery phase. There were significant differences between the early and recovery phases for V<sub>d,an</sub> (mean difference in V<sub>d,an</sub>/kg = 0.57 mL/kg; 95% confidence interval [CI], 0.38–0.77; mean difference in V<sub>d,an</sub>/V<sub>T</sub> = 0.10; 95% CI, 0.07–0.14) and V<sub>A</sub> (mean difference in V<sub>A</sub>/kg = –0.60 mL/kg; 95% CI, –0.94 to –0.27; mean difference in V<sub>A</sub>/V<sub>T</sub> = –0.12; 95% CI, –0.15 to –0.09), despite no difference in V<sub>T</sub>. <b><i>Conclusions:</i></b> We evaluated changes in V<sub>d,an</sub> and V<sub>A</sub> during mechanical ventilation using V<sub>cap</sub> based on waveforms. The increase in V<sub>d,an</sub> and decrease in V<sub>A</sub> suggested dilation of the airways and collapse of the alveoli in ventilated infants with low lung compliance.
DOI: 10.6084/m9.figshare.11353772.v1
title: Supplementary Material for: Ventilated Infants Have Increased Dead Space and Lower Alveolar Tidal Volumes during the Early versus Recovery Phase of Respiratory Distress

description: <b><i>Background:</i></b> Few studies have reported the measurement of anatomical dead space (V<sub>d,an</sub>) and alveolar tidal volume (V<sub>A</sub>) in ventilated neonates with respiratory distress. <b><i>Objective:</i></b> The aim of this study was to determine the differences in V<sub>d,an</sub> and V<sub>A</sub> in ventilated infants between the early and recovery phases of respiratory distress using volumetric ­capnography (V<sub>cap</sub>) based on ventilator graphics and capnograms. <b><i>Methods:</i></b> This study enrolled twenty-five ventilated infants (mean birth weight, 2,220 ± 635 g; mean gestational age, 34.7 ± 3.3 weeks). We adjusted respiratory settings to maintain appropriate oxygenation and tidal volume (V<sub>T</sub>), and performed V<sub>cap</sub> based on waveforms of ventilator graphics and capnograms. V<sub>d,an</sub> and V<sub>A</sub>were measured in infants with respiratory disorders, immediately after intubation (early phase) and subsequently when they were clinically stable (recovery phase). <b><i>Results:</i></b> The early phase, with lower dynamic lung compliance, required a higher level of ventilator support, not positive end-expiratory pressure, than the recovery phase. There were significant differences between the early and recovery phases for V<sub>d,an</sub> (mean difference in V<sub>d,an</sub>/kg = 0.57 mL/kg; 95% confidence interval [CI], 0.38–0.77; mean difference in V<sub>d,an</sub>/V<sub>T</sub> = 0.10; 95% CI, 0.07–0.14) and V<sub>A</sub> (mean difference in V<sub>A</sub>/kg = –0.60 mL/kg; 95% CI, –0.94 to –0.27; mean difference in V<sub>A</sub>/V<sub>T</sub> = –0.12; 95% CI, –0.15 to –0.09), despite no difference in V<sub>T</sub>. <b><i>Conclusions:</i></b> We evaluated changes in V<sub>d,an</sub> and V<sub>A</sub> during mechanical ventilation using V<sub>cap</sub> based on waveforms. The increase in V<sub>d,an</sub> and decrease in V<sub>A</sub> suggested dilation of the airways and collapse of the alveoli in ventilated infants with low lung compliance.
DOI: 10.6084/m9.figshare.11353799.v1
title: Differential metabolites of DM patients after CABG procedure.

description: Note: Metabolites between two groups were considered different when the p-value of the T test &lt; 0.05 and VIP ≥ 1. Abbreviations: CABG, Coronary artery bypass grafting; A, preoperative sample; B, postoperative sample; VIP, variable importance in projection.
DOI: 10.6084/m9.figshare.11353754
title: Supplementary Material for: Microvascular Invasion and a Size Cutoff Value of 2 cm Predict Long-Term Oncological Outcome in Multiple Hepatocellular Carcinoma: Reappraisal of the American Joint Committee on Cancer Staging System and Validation Using the Surveillance, Epidemiology, and End-Results Database

description: <b><i>Introduction:</i></b> For prognostication of hepatocellular carcinoma (HCC), the optimal size cutoff value and the significance of microvascular invasion (mvi) remain inconclusive. <b><i>Objective:</i></b> This study sought to revisit the inconclusive components of current American Joint Committee on Cancer (AJCC) staging system and to develop a new practical prognostication model for patients with HCC based on 2 large cohorts. <b><i>Method:</i></b> In 1,175 patients who underwent resection for HCC (training cohort), prognostic significance of mvi, and optimal size cutoff value were revisited and a new staging model was established. Then, its performance was validated using 5,249 patients derived from a population-based database (validation cohort). <b><i>Results:</i></b> The optimal size cutoff value was 2 cm in multiple HCC, similar to that for solitary HCC. Multivariate analyses confirmed that mvi, a size &gt;2 cm, and multiple lesions were independent predictors with similar weights for disease-specific survival. Based on these results, earlier stages of HCC were reclassified according to the number of the following factors: multiple tumors, &gt;2 cm in diameter, and presence of mvi. Also, given the similar prognosis of Stages IIIB and IVA according to the AJCC 8th edition, these groups were reclassified into the same stage. This new staging model had a better performance than the AJCC 8th edition in both training cohort (c-statistics, 0.648 vs. 0.629) and the validation cohort (c-statistics, 0.646 vs. 0.645) regardless of the presence of cirrhosis. <b><i>Conclusions:</i></b> Inclusion of a size cutoff value of 2 cm and mvi could reclassify the current version of the AJCC staging system and offer an alternative prognostication model using a single size-cutoff value of HCC.
DOI: 10.6084/m9.figshare.11353664
title: Metadata record for: High-resolution and bias-corrected CMIP5 projections for climate change impact assessments

description: This dataset contains key characteristics about the data described in the Data Descriptor High-resolution and bias-corrected CMIP5 projections for climate change impact assessments. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <b><br> </b>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.11353754.v1
title: Supplementary Material for: Microvascular Invasion and a Size Cutoff Value of 2 cm Predict Long-Term Oncological Outcome in Multiple Hepatocellular Carcinoma: Reappraisal of the American Joint Committee on Cancer Staging System and Validation Using the Surveillance, Epidemiology, and End-Results Database

description: <b><i>Introduction:</i></b> For prognostication of hepatocellular carcinoma (HCC), the optimal size cutoff value and the significance of microvascular invasion (mvi) remain inconclusive. <b><i>Objective:</i></b> This study sought to revisit the inconclusive components of current American Joint Committee on Cancer (AJCC) staging system and to develop a new practical prognostication model for patients with HCC based on 2 large cohorts. <b><i>Method:</i></b> In 1,175 patients who underwent resection for HCC (training cohort), prognostic significance of mvi, and optimal size cutoff value were revisited and a new staging model was established. Then, its performance was validated using 5,249 patients derived from a population-based database (validation cohort). <b><i>Results:</i></b> The optimal size cutoff value was 2 cm in multiple HCC, similar to that for solitary HCC. Multivariate analyses confirmed that mvi, a size &gt;2 cm, and multiple lesions were independent predictors with similar weights for disease-specific survival. Based on these results, earlier stages of HCC were reclassified according to the number of the following factors: multiple tumors, &gt;2 cm in diameter, and presence of mvi. Also, given the similar prognosis of Stages IIIB and IVA according to the AJCC 8th edition, these groups were reclassified into the same stage. This new staging model had a better performance than the AJCC 8th edition in both training cohort (c-statistics, 0.648 vs. 0.629) and the validation cohort (c-statistics, 0.646 vs. 0.645) regardless of the presence of cirrhosis. <b><i>Conclusions:</i></b> Inclusion of a size cutoff value of 2 cm and mvi could reclassify the current version of the AJCC staging system and offer an alternative prognostication model using a single size-cutoff value of HCC.
DOI: 10.17633/rd.brunel.11353652
title: Rewarding the Good and Punishing the Bad: Singapore data from two studies.

description: Two datasets collected in Singapore examining 1) how different religious beliefs relate to perceptions about the consequences of good and bad actions; and 2) how afterlife beliefs are related to generosity.
DOI: 10.6084/m9.figshare.11353655
title: Revealing the stoichiometric tolerance of lead tri-halide perovskite thin-films - raw data

description: Raw data encompassing: x-ray, UV and inverse photoemission spectroscopy measurements, atomic force microscopy measurements, x-ray diffraction, photoluminescence and absorption spectroscopy of cesium lead bromide thin films.<br>
DOI: 10.17633/rd.brunel.11353652.v1
title: Rewarding the Good and Punishing the Bad: Singapore data from two studies.

description: Two datasets collected in Singapore examining 1) how different religious beliefs relate to perceptions about the consequences of good and bad actions; and 2) how afterlife beliefs are related to generosity.
DOI: 10.6084/m9.figshare.11353655.v1
title: Revealing the stoichiometric tolerance of lead tri-halide perovskite thin-films - raw data

description: Raw data encompassing: x-ray, UV and inverse photoemission spectroscopy measurements, atomic force microscopy measurements, x-ray diffraction, photoluminescence and absorption spectroscopy of cesium lead bromide thin films.<br>
DOI: 10.6084/m9.figshare.11353664.v2
title: Metadata record for: High-resolution and bias-corrected CMIP5 projections for climate change impact assessments

description: This dataset contains key characteristics about the data described in the Data Descriptor High-resolution and bias-corrected CMIP5 projections for climate change impact assessments. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format <br> <b><br> </b>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.11353601
title: Plants with self-sustained luminescence

description: Supplementary Data from the manuscript "Plants with self-sustained luminescence". Unprocessed images of luminescent flowers captured on Sony Alpha ILCE-7M3 camera and IVIS Spectrum CT, and analysis of luminescence intensity of flowers.<br><br>Folder 01. Raw files from IVIS Spectrum CT (source images for Supplementary Figure 4b). <br><br>Folder 02. Raw files from Sony Alpha ILCE-7M3 camera. Photos with ISO 3200 and shutter speed 30 sec (source for Supplementary Figure 4d), as well as with ISO 20000, with corresponding dark frames captured with the same settings but with objective lens closed. Also, a photo with 500 ms exposure and ISO 204800. Images were acquired with Samyang 35mm T1.5 ED AS UMC VDSLR lens, T = 1.5, the distance between the camera sensor and the samples was 40 cm. <br><br>
DOI: 10.6084/m9.figshare.11353664.v1
title: Metadata record for: High-resolution and bias-corrected CMIP5 projections for climate change impact assessments

description: This dataset contains key characteristics about the data described in the Data Descriptor High-resolution and bias-corrected CMIP5 projections for climate change impact assessments. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.11353634.v1
title: Magnesium and lithium isotopic evidence for a remnant oceanic slab beneath central Tibet

description: This EXCEL dataset provides the data on two suites of volcanic rocks from the northern Qiangtang, Tibet
DOI: 10.6084/m9.figshare.11353634.v2
title: Tian et al. JGR (2019)

description: This EXCEL dataset provides the data on two suites of volcanic rocks from the northern Qiangtang, Tibet
DOI: 10.6084/m9.figshare.11353634.v4
title: Tian et al. JGR (2019)

description: This EXCEL dataset provides the data on two suites of volcanic rocks from the northern Qiangtang, Tibet
DOI: 10.6084/m9.figshare.11353550
title: Supplementary Material for: Brusatol Protects HepG2 Cells against Oxygen-Glucose Deprivation-Induced Injury via Inhibiting Mitochondrial Reactive Oxygen Species-Induced Oxidative Stress

description: <b><i>Background:</i></b> It has been reported that brusatol (BRU) reduces cellular reactive oxygen species (ROS) level under hypoxia; here the protective effect of BRU against oxygen-glucose deprivation/reoxygenation (OGD-R)-induced injury in HepG2 cells and against anoxia/reoxygenation (A/R)-induced injury in rat liver mitochondria was investigated. <b><i>Materials and Methods:</i></b> OGD-R-induced HepG2 cell viability loss was detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide and trypan blue staining. Mitochondrial ROS level in HepG2 cells was measured by MitoSOX staining. The cellular malondialdehyde and adenosine triphosphate level was measured by commercial kits. The mitochondrial membrane potential in HepG2 cells was measured by JC-1 staining. The protein level was detected by Western blotting. Rat liver mitochondria were separated by differential centrifugation. A/R-induced injury in isolated rat liver mitochondria was established by using a Clark oxygen electrode. The ROS generation in isolated mitochondria was evaluated using Amplex red/horseradish peroxidase. <b><i>Results:</i></b> BRU reduced mitochondrial ROS level and alleviated oxidative injury in HepG2 cells, thereby significantly inhibited OGD-R-induced cell death. During OGD-R, BRU improved mitochondrial function and inhibited the release of cytochrome c. Furthermore, BRU showed a clear protective effect against A/R-induced injury in isolated rat liver mitochondria. When isolated rat liver mitochondria were pretreated with BRU, A/R-induced ROS generation was significantly decreased, and mitochondrial respiratory dysfunction was ameliorated. <b><i>Conclusions:</i></b> BRU pretreatment attenuated OGD-R-induced injury in HepG2 cells and A/R-induced injury in isolated rat liver mitochondria by inhibiting mitochondrial ROS-induced oxidative stress.
DOI: 10.6084/m9.figshare.11353634.v3
title: Tian et al. JGR (2019)

description: This EXCEL dataset provides the data on two suites of volcanic rocks from the northern Qiangtang, Tibet
DOI: 10.6084/m9.figshare.11353448
title: Supplemental 2

description: <b>Supplemental Table 2</b>. First and all ejaculates analyses of semen
DOI: 10.6084/m9.figshare.11353433
title: A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory

description: This is the experimental data of the manuscript entitled "A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory". All data are generated through computer simulation and saved in the file with csv format. The data are the simulation of the real-world case. There are nine instances for these experiments, which cover multiple scales. Three attributes including time, cost, and reliability of servies for achieving corresponding subtasks are shown in datasets.
DOI: 10.6084/m9.figshare.11353433.v1
title: A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory

description: This is the experimental data of the manuscript entitled "A utility-aware multi-task scheduling method in cloud manufacturing using extended NSGA-II embedded with game theory". All data are generated through computer simulation and saved in the file with csv format. The data are the simulation of the real-world case. There are nine instances for these experiments, which cover multiple scales. Three attributes including time, cost, and reliability of servies for achieving corresponding subtasks are shown in datasets.
DOI: 10.6084/m9.figshare.11353448.v1
title: Supplemental 2

description: <b>Supplemental Table 2</b>. First and all ejaculates analyses of semen
DOI: 10.6084/m9.figshare.11353391.v1
title: FIXATIONS AND RECOGNITION OF DYNAMIC AND STATIC FACIAL EMOTIONS IN SOCIAL ANXIETY

description: Estudos demonstram um viés atencional negativo para o reconhecimento de emoções além da hipervigilância por parte dos sujeitos com ansiedade social (AS) ao observarem uma face. Entretanto, as evidências acerca desses estímulos em condições dinâmicas e estáticas são escassas. O presente estudo buscou investigar o reconhecimento de expressões faciais dinâmicas e estáticas associado com a varredura ocular em sujeitos com sintomas de AS e controles. Participaram 56 voluntários, sendo 28 com sintomas de AS – grupo experimental (GE) e 28 controles – grupo controle (GC). As emoções de alegria, nojo, raiva e tristeza foram apresentadas na condição estática e dinâmica nas intensidades de 25, 50, 75 e 100%. Durante o reconhecimento foi realizada a captura binocular das fixações, sendo analisados o número e o tempo médio de duração. ANOVA para medidas repetidas revelou que apenas para tristeza 25% o GE apresentou maior taxa de acerto (p &lt; 0,001; η<sup>2</sup> = 0,216). Nas faces dinâmicas o GE fixou mais vezes do que o GC (p &lt; 0,001; η<sup>2</sup> = 0,179), porém o GC teve fixações mais duradouras do que o GE (p = 0,016; η<sup>2</sup> = 0,103). Ocorreram fixações mais duradouras do GC também na estática (p &lt; 0,001; η<sup>2</sup> = 0,357). O grupo com sintomas de AS apresentou hipervigilância para fotografias e vídeos, mas isso não influenciou no reconhecimento das expressões apresentadas nessas condições.