cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31312633
title: Supplementary Material for: Impact of nasal bridles on nasogastric tube dislodgement and nutritional adequacy in acute stroke patients – a pre-post study.

description: Introduction: Nasogastric tube (NET) dislodgement is common in dysphagic stroke patients, impacting nutritional adequacy and health resourcing. Nasal bridles can reduce dislodgement risk, but their routine use following acute stroke has not been rigorously evaluated. We assessed whether routine nasal bridle use reduces NET dislodgements and its impact. 

Methods: A single-centre pre-post observational study in stroke patients receiving a NET involved: 6-month baseline period (pre); and routine nasal bridle insertion (post). NET dislodgements (primary outcome) and enteral nutrition (EN) adequacy in the pre and post groups were compared using negative binomial and ordered beta regression models, respectively, adjusted for patient and stroke characteristics. Data are mean±standard deviation and adjusted rate ratios (aRR) with 95% confidence interval (CI). 

Results: 119 patients (70 pre, 49 post) were enrolled (median [interquartile range] 78 [70-84] vs 79 [73-86] years; male 46% vs 61%; National Institute of Health Stroke Scale scores 13 [8-21] vs 14 [10-21]. NET dislodgements were significantly lower in the post group (Mean±SD 1.8±1.7 pre vs 1.6±2.1 post; aRR 0.624 (95% CI 0.41-0.92; p=0.019)) and with bridle (1.7±1.6 no bridle vs 1.1±1.7 bridle; aRR 0.52 (95% CI 0.35-0.79; p=0.002)). EN adequacy was higher in the post group (77.0% pre vs 91.5% post) and those with a bridle (84.2% no bridle vs 96.9% bridle). 

Conclusion: Routine nasal bridle insertions following stroke may reduce NET dislodgement frequency and improve nutritional adequacy, yet this requires confirmation in a prospective randomised trial.
DOI: 10.6084/m9.figshare.31312633.v1
title: Supplementary Material for: Impact of nasal bridles on nasogastric tube dislodgement and nutritional adequacy in acute stroke patients – a pre-post study.

description: Introduction: Nasogastric tube (NET) dislodgement is common in dysphagic stroke patients, impacting nutritional adequacy and health resourcing. Nasal bridles can reduce dislodgement risk, but their routine use following acute stroke has not been rigorously evaluated. We assessed whether routine nasal bridle use reduces NET dislodgements and its impact. 

Methods: A single-centre pre-post observational study in stroke patients receiving a NET involved: 6-month baseline period (pre); and routine nasal bridle insertion (post). NET dislodgements (primary outcome) and enteral nutrition (EN) adequacy in the pre and post groups were compared using negative binomial and ordered beta regression models, respectively, adjusted for patient and stroke characteristics. Data are mean±standard deviation and adjusted rate ratios (aRR) with 95% confidence interval (CI). 

Results: 119 patients (70 pre, 49 post) were enrolled (median [interquartile range] 78 [70-84] vs 79 [73-86] years; male 46% vs 61%; National Institute of Health Stroke Scale scores 13 [8-21] vs 14 [10-21]. NET dislodgements were significantly lower in the post group (Mean±SD 1.8±1.7 pre vs 1.6±2.1 post; aRR 0.624 (95% CI 0.41-0.92; p=0.019)) and with bridle (1.7±1.6 no bridle vs 1.1±1.7 bridle; aRR 0.52 (95% CI 0.35-0.79; p=0.002)). EN adequacy was higher in the post group (77.0% pre vs 91.5% post) and those with a bridle (84.2% no bridle vs 96.9% bridle). 

Conclusion: Routine nasal bridle insertions following stroke may reduce NET dislodgement frequency and improve nutritional adequacy, yet this requires confirmation in a prospective randomised trial.
DOI: 10.6084/m9.figshare.31312636
title: Supplementary Material for: Urinary Metabolomics Study on Acupuncture plus Wet Cupping Therapy for Post Stroke Depression: A pilot study

description: Objective: This study aimed to investigate urinary metabolomics alterations associated with acupuncture plus wet cupping (AC) therapy in patients with post-stroke depression (PSD).
Methods: A total of 40 subjects were randomly allocated to either the acupuncture plus wet cupping group (AC group, n=20) or the acupuncture group (Acu group, n=20). Morning urine samples were collected at baseline and after 4 weeks of treatment, yielding a total of 80 samples. An additional 20 healthy volunteers served as a blank control group, from whom urine samples were also obtained. Urinary metabolites were analyzed using gas chromatography-mass spectrometry (GC-MS). Differential metabolites and related metabolic pathways were identified. Clinical efficacy was assessed using the Hamilton Depression Rating Scale-24 items (HAMD-24) at baseline and post-treatment. Correlation analysis was performed to assess the relationship between metabolic changes and clinical improvement. 
Results: After 4 weeks of treatment, the HAMD-24 scores in the AC group (median: 10.00, IQR: 9.00-13.00) were significantly lower than those in the Acu group (median: 18.00, IQR: 15.25-19.00), with a statistically significant between-group difference (P&lt;0.01). Metabolomic profiling revealed significant differences between healthy volunteers and untreated PSD patients, with 21 differential metabolites identified. Caffeine metabolism emerged as the most significantly altered pathway (FDR-P&lt;0.05). No significant metabolic changes were detected in the Acu group after treatment. In contrast, the AC group demonstrated marked alterations, with 33 differential metabolites identified and starch and sucrose metabolism emerging as the most affected pathway (FDR-P&lt;0.05). Furthermore, direct comparisons between the AC and Acu groups post-treatment identified 13 differential metabolites, with tyrosine metabolism as the most significantly impacted pathway (FDR-P&lt;0.05). Correlation analysis showed that the differential metabolites in the AC group were significantly correlated with HAMD-24 score changes (P&lt;0.05).
Conclusions: Caffeine metabolism was associated with the metabolic distinction between healthy volunteers and PSD patients. AC therapy was associated with clinical improvement in PSD and alterations in starch and sucrose metabolism as well as tyrosine metabolism. Tyrosine metabolism may be the key metabolic pathway distinguishing AC therapy from acupuncture alone. These findings suggested that AC therapy may exert its effects through associations with alterations in energy metabolism and neurotransmitter synthesis, which was linked to the core pathophysiological mechanisms of PSD, though causal relationships require further investigation.
DOI: 10.6084/m9.figshare.31312636.v1
title: Supplementary Material for: Urinary Metabolomics Study on Acupuncture plus Wet Cupping Therapy for Post Stroke Depression: A pilot study

description: Objective: This study aimed to investigate urinary metabolomics alterations associated with acupuncture plus wet cupping (AC) therapy in patients with post-stroke depression (PSD).
Methods: A total of 40 subjects were randomly allocated to either the acupuncture plus wet cupping group (AC group, n=20) or the acupuncture group (Acu group, n=20). Morning urine samples were collected at baseline and after 4 weeks of treatment, yielding a total of 80 samples. An additional 20 healthy volunteers served as a blank control group, from whom urine samples were also obtained. Urinary metabolites were analyzed using gas chromatography-mass spectrometry (GC-MS). Differential metabolites and related metabolic pathways were identified. Clinical efficacy was assessed using the Hamilton Depression Rating Scale-24 items (HAMD-24) at baseline and post-treatment. Correlation analysis was performed to assess the relationship between metabolic changes and clinical improvement. 
Results: After 4 weeks of treatment, the HAMD-24 scores in the AC group (median: 10.00, IQR: 9.00-13.00) were significantly lower than those in the Acu group (median: 18.00, IQR: 15.25-19.00), with a statistically significant between-group difference (P&lt;0.01). Metabolomic profiling revealed significant differences between healthy volunteers and untreated PSD patients, with 21 differential metabolites identified. Caffeine metabolism emerged as the most significantly altered pathway (FDR-P&lt;0.05). No significant metabolic changes were detected in the Acu group after treatment. In contrast, the AC group demonstrated marked alterations, with 33 differential metabolites identified and starch and sucrose metabolism emerging as the most affected pathway (FDR-P&lt;0.05). Furthermore, direct comparisons between the AC and Acu groups post-treatment identified 13 differential metabolites, with tyrosine metabolism as the most significantly impacted pathway (FDR-P&lt;0.05). Correlation analysis showed that the differential metabolites in the AC group were significantly correlated with HAMD-24 score changes (P&lt;0.05).
Conclusions: Caffeine metabolism was associated with the metabolic distinction between healthy volunteers and PSD patients. AC therapy was associated with clinical improvement in PSD and alterations in starch and sucrose metabolism as well as tyrosine metabolism. Tyrosine metabolism may be the key metabolic pathway distinguishing AC therapy from acupuncture alone. These findings suggested that AC therapy may exert its effects through associations with alterations in energy metabolism and neurotransmitter synthesis, which was linked to the core pathophysiological mechanisms of PSD, though causal relationships require further investigation.
DOI: 10.34740/kaggle/dsv/11985349
title: Macao-ebird
DOI: 10.6084/m9.figshare.31312639
title: Supplementary Material for: Efficacy and safety of acupuncture-related interventions for fatigue, quality of life, and cancer-related indicators in cancer patients: a systematic review and network meta-analysis

description: ABSTRACT
Objective: Although studies have explored the analysis of acupuncture therapy in the treatment of cancer-related fatigue, there are still deficiencies in terms of the degree of fatigue, quality of life, and cancer-related indicators. The best option remains elusive regarding the degree of improvement in these aspects. This systematic review and network meta-analysis compared the efficacy of various acupuncture therapies on the degree of fatigue, quality of life, and cancer-related indicators (natural killer (NK) cells, CD3+ cells, CD4+ cells) among cancer survivors.
Methods: A comprehensive literature search was conducted across eight databases from their establishment to September. The methodological quality of the included randomized controlled trials (RCTs) was assessed using the Cochrane Collaboration’s Risk of Bias Tool. Pairwise meta-analysis was performed in Review Manager (version 5.3), while traditional meta-analysis for continuous outcomes was conducted using Stata 18.0 software with a random-effects model, reporting effect sizes as both standardized mean differences (SMDs) and weighted mean differences (WMDs). Network meta-analysis (NMA) was employed to synthesize the data, with network diagrams illustrating comparisons between interventions for different outcome measures. We evaluated the consistency of results, performed sensitivity analyses, and examined publication bias to assess its influence on individual studies. Additionally, subgroup and network meta-regression analyses were conducted to explore potential sources of heterogeneity.
Results: This study included 30 studies involving 2287 patients and 6 acupuncture-related interventions. Our results suggest that acupuncture methods have great advantages in improving fatigue, quality of life, and cancer-related indicators in cancer survivors. In particular, moxibustion may be the best acupuncture modality for improving CRF, quality of life, CD3+ cells, and CD4+ cells. In contrast, warm acupuncture contributes more to increasing natural killer (NK) cells. Sensitivity analysis validated the robustness of the research findings. Although there was publication bias, it did not affect the overall results of the network meta-analysis.
Conclusion: Our findings suggest that moxibustion has great potential in treating CRF. It may improve quality of life, CD3+ cells, and CD4+ cells. For natural killer (NK) cells, warm acupuncture may be the optimal regimen to personalize the treatment when clinical problems are encountered.
DOI: 10.6084/m9.figshare.31312639.v1
title: Supplementary Material for: Efficacy and safety of acupuncture-related interventions for fatigue, quality of life, and cancer-related indicators in cancer patients: a systematic review and network meta-analysis

description: ABSTRACT
Objective: Although studies have explored the analysis of acupuncture therapy in the treatment of cancer-related fatigue, there are still deficiencies in terms of the degree of fatigue, quality of life, and cancer-related indicators. The best option remains elusive regarding the degree of improvement in these aspects. This systematic review and network meta-analysis compared the efficacy of various acupuncture therapies on the degree of fatigue, quality of life, and cancer-related indicators (natural killer (NK) cells, CD3+ cells, CD4+ cells) among cancer survivors.
Methods: A comprehensive literature search was conducted across eight databases from their establishment to September. The methodological quality of the included randomized controlled trials (RCTs) was assessed using the Cochrane Collaboration’s Risk of Bias Tool. Pairwise meta-analysis was performed in Review Manager (version 5.3), while traditional meta-analysis for continuous outcomes was conducted using Stata 18.0 software with a random-effects model, reporting effect sizes as both standardized mean differences (SMDs) and weighted mean differences (WMDs). Network meta-analysis (NMA) was employed to synthesize the data, with network diagrams illustrating comparisons between interventions for different outcome measures. We evaluated the consistency of results, performed sensitivity analyses, and examined publication bias to assess its influence on individual studies. Additionally, subgroup and network meta-regression analyses were conducted to explore potential sources of heterogeneity.
Results: This study included 30 studies involving 2287 patients and 6 acupuncture-related interventions. Our results suggest that acupuncture methods have great advantages in improving fatigue, quality of life, and cancer-related indicators in cancer survivors. In particular, moxibustion may be the best acupuncture modality for improving CRF, quality of life, CD3+ cells, and CD4+ cells. In contrast, warm acupuncture contributes more to increasing natural killer (NK) cells. Sensitivity analysis validated the robustness of the research findings. Although there was publication bias, it did not affect the overall results of the network meta-analysis.
Conclusion: Our findings suggest that moxibustion has great potential in treating CRF. It may improve quality of life, CD3+ cells, and CD4+ cells. For natural killer (NK) cells, warm acupuncture may be the optimal regimen to personalize the treatment when clinical problems are encountered.
DOI: 10.6084/m9.figshare.31312642
title: Supplementary Material for: Burden of glomerular diseases in Australia: a data linkage study

description: Introduction. Glomerular diseases are rare but associated with substantial morbidity. Existing studies focus mainly on kidney failure and mortality, often overlooking multi-system complications. This first Australian, population-based study uses linked routinely collected health data to estimate incidence, prevalence, and long-term outcomes, capturing cardiovascular, thrombotic, infectious, and healthcare burdens.

Methods. We conducted a population-based cohort study of adults ≥45 years in New South Wales, Australia (2005-2009, n=267,357), using the 45 and Up Study with probabilistic data linkage via CHeReL and the Sax Institute. Glomerular disease was identified using nephrology specialist reviews, ICD-10-AM codes, kidney biopsy procedure codes, and the Australian and New Zealand Dialysis and Transplant (ANZDATA) registry. Age-standarised glomerular disease prevalence and incidence were estimated. Kaplan-Meier curves and Cox regression models evaluated all-cause mortality, major cardiovascular events (MACE; composite of acute myocardial infarction (AMI), stroke, and all-cause mortality), venous thromboembolism, and any hospitalised infection. Subdistribution hazard models assessed kidney replacement therapy (KRT) risk, accounting for the competing risk of death. 

Results. We identified 365 participants with glomerular disease (n=195 prevalent, n=170 incident; 67% male, mean age 65 years). The age-standardised prevalence and incidence of glomerular disease was 89/100,000 persons and 12/100,000 person-years-at-risk, respectively. After a median follow-up of 6 years, prevalent disease participants had a higher adjusted risk (HR; 95% CI; all P-values &lt;0.001) of all-cause mortality (2.18; 1.60–2.99), KRT (31.3; 12.7–77.2), MACE (2.17; 1.59–2.96), AMI (3.84; 2.05–7.20), stroke (3.58; 1.69–7.56), venous thromboembolism (2.93; 1.76–4.89), and any hospitalised infection (2.92; 2.42–3.54). The 5-year risk of complications was comparable between prevalent and incident cases. Hospitalisation burden was also significantly higher among glomerular disease participants (P&lt;0.001).

Conclusions. Using linked data, this study reveals the substantial multi-system burden of glomerular diseases, including kidney failure, death, cardiovascular events, infections and hospitalisations in adults aged 45 and over.
DOI: 10.6084/m9.figshare.31312642.v1
title: Supplementary Material for: Burden of glomerular diseases in Australia: a data linkage study

description: Introduction. Glomerular diseases are rare but associated with substantial morbidity. Existing studies focus mainly on kidney failure and mortality, often overlooking multi-system complications. This first Australian, population-based study uses linked routinely collected health data to estimate incidence, prevalence, and long-term outcomes, capturing cardiovascular, thrombotic, infectious, and healthcare burdens.

Methods. We conducted a population-based cohort study of adults ≥45 years in New South Wales, Australia (2005-2009, n=267,357), using the 45 and Up Study with probabilistic data linkage via CHeReL and the Sax Institute. Glomerular disease was identified using nephrology specialist reviews, ICD-10-AM codes, kidney biopsy procedure codes, and the Australian and New Zealand Dialysis and Transplant (ANZDATA) registry. Age-standarised glomerular disease prevalence and incidence were estimated. Kaplan-Meier curves and Cox regression models evaluated all-cause mortality, major cardiovascular events (MACE; composite of acute myocardial infarction (AMI), stroke, and all-cause mortality), venous thromboembolism, and any hospitalised infection. Subdistribution hazard models assessed kidney replacement therapy (KRT) risk, accounting for the competing risk of death. 

Results. We identified 365 participants with glomerular disease (n=195 prevalent, n=170 incident; 67% male, mean age 65 years). The age-standardised prevalence and incidence of glomerular disease was 89/100,000 persons and 12/100,000 person-years-at-risk, respectively. After a median follow-up of 6 years, prevalent disease participants had a higher adjusted risk (HR; 95% CI; all P-values &lt;0.001) of all-cause mortality (2.18; 1.60–2.99), KRT (31.3; 12.7–77.2), MACE (2.17; 1.59–2.96), AMI (3.84; 2.05–7.20), stroke (3.58; 1.69–7.56), venous thromboembolism (2.93; 1.76–4.89), and any hospitalised infection (2.92; 2.42–3.54). The 5-year risk of complications was comparable between prevalent and incident cases. Hospitalisation burden was also significantly higher among glomerular disease participants (P&lt;0.001).

Conclusions. Using linked data, this study reveals the substantial multi-system burden of glomerular diseases, including kidney failure, death, cardiovascular events, infections and hospitalisations in adults aged 45 and over.
DOI: 10.15468/dl.gptau7
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Nannostomus mortenthaleri",
 "DecimalLatitude is not null",
 "DecimalLongitude is not null"
 ]
}

 The dataset includes 6 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007560-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.def8tt
title: Occurrence Download

description: A dataset containing 128 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Agave tequilana",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 128 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007562-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/14804011
title: World Weather Repository ( Daily Updating )
DOI: 10.5281/zenodo.18014027
title: The m6A demethylase FTO targets NF-κB signaling to inhibit vascular calcification in chronic  kidney disease

description: Vascular smooth muscle cells were isolated from mice and divided into control and Fto-knockdown groups and treated with small interfering RNA for 7 days. Total RNA was then extracted from both groups, and m6A RNA methylation sequencing (MeRIP-seq) was performed to investigate which genes were altered following Fto knockdown.
DOI: 10.5281/zenodo.18014026
title: The m6A demethylase FTO targets NF-κB signaling to inhibit vascular calcification in chronic  kidney disease

description: Vascular smooth muscle cells were isolated from mice and divided into control and Fto-knockdown groups and treated with small interfering RNA for 7 days. Total RNA was then extracted from both groups, and m6A RNA methylation sequencing (MeRIP-seq) was performed to investigate which genes were altered following Fto knockdown.