cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19923019
title: Periostin regulates osteogenesis of mesenchymal stem cells from ovariectomized rats through actions on the ILK/Akt/GSK-3β Axis

description: Abstract Osteoporosis is a condition of the skeleton that mainly results from estrogen deficiency. Periostin is a matricellular component in bone that is involved in osteoblast differentiation. However, how Periostin promotes osteogenesis remains largely unknown. Here, we isolated bone marrow skeletal stem cells (BMSCs) derived from an ovariectomy (OVX)-induced osteoporosis rat model and the effects of periostin on BMSCs derived from OVX rats (OVX-BMSCs) were assessed. Overexpression of periostin enhanced alkaline phosphatase (ALP) and alizarin red staining in OVX-BMSCs as well as the osteogenic genes OCN, BSP and Runx2. ILK is a downstream effector of signals from the extracellular matrix and participates in bone homeostasis. Overexpression of periostin also increased expression of protein levels for ILK, as well as the downstream targets pAkt and pGSK3β. Suppression of ILK or Akt partially suppressed the enhancement of osteogenic ability induced by periostin overexpression in OVX-BMSCs. Thus, periostin may promote the osteogenic ability of OVX-BMSCs through actions on the ILK/Akt/GSK3β axis.
DOI: 10.6084/m9.figshare.19923019.v1
title: Periostin regulates osteogenesis of mesenchymal stem cells from ovariectomized rats through actions on the ILK/Akt/GSK-3β Axis

description: Abstract Osteoporosis is a condition of the skeleton that mainly results from estrogen deficiency. Periostin is a matricellular component in bone that is involved in osteoblast differentiation. However, how Periostin promotes osteogenesis remains largely unknown. Here, we isolated bone marrow skeletal stem cells (BMSCs) derived from an ovariectomy (OVX)-induced osteoporosis rat model and the effects of periostin on BMSCs derived from OVX rats (OVX-BMSCs) were assessed. Overexpression of periostin enhanced alkaline phosphatase (ALP) and alizarin red staining in OVX-BMSCs as well as the osteogenic genes OCN, BSP and Runx2. ILK is a downstream effector of signals from the extracellular matrix and participates in bone homeostasis. Overexpression of periostin also increased expression of protein levels for ILK, as well as the downstream targets pAkt and pGSK3β. Suppression of ILK or Akt partially suppressed the enhancement of osteogenic ability induced by periostin overexpression in OVX-BMSCs. Thus, periostin may promote the osteogenic ability of OVX-BMSCs through actions on the ILK/Akt/GSK3β axis.
DOI: 10.6084/m9.figshare.19923122
title: Genome-wide analysis of the maize superoxide dismutase (SOD) gene family reveals important roles in drought and salt responses

description: Abstract Superoxide dismutase proteins (SODs) are antioxidant enzymes with important roles in abiotic stress responses. The SOD gene family has been systematically analyzed in many plants; however, it is still poorly understood in maize. Here, a bioinformatics analysis of maize SOD gene family was conducted by describing gene structure, conserved motifs, phylogenetic relationships, gene duplications, promoter cis-elements and GO annotations. In total, 13 SOD genes were identified in maize and five members were involved in segmental duplication. Phylogenetic analysis indicated that SODs from maize and other plants comprised two groups, which could be further classified into different subgroups, with most members in the same subgroup having the same subcellular localization. The ZmSOD promoters contained 2-10 stress-responsive cis-elements with different distributions. Heatmap analysis indicated that ZmSODs were expressed in most of the detected tissues and organs. The expression patterns of ZmSODs were investigated under drought and salt treatments by qRT-PCR, and most members were responsive to drought or salt stress, especially some ZmSODs with significant expression changes were identified, such as ZmCSD2 and ZmMSD2, suggesting the important roles of ZmSODs in abiotic stress responses. Our results provide an important basis for further functional study of ZmSODs in future study.
DOI: 10.6084/m9.figshare.19923122.v1
title: Genome-wide analysis of the maize superoxide dismutase (SOD) gene family reveals important roles in drought and salt responses

description: Abstract Superoxide dismutase proteins (SODs) are antioxidant enzymes with important roles in abiotic stress responses. The SOD gene family has been systematically analyzed in many plants; however, it is still poorly understood in maize. Here, a bioinformatics analysis of maize SOD gene family was conducted by describing gene structure, conserved motifs, phylogenetic relationships, gene duplications, promoter cis-elements and GO annotations. In total, 13 SOD genes were identified in maize and five members were involved in segmental duplication. Phylogenetic analysis indicated that SODs from maize and other plants comprised two groups, which could be further classified into different subgroups, with most members in the same subgroup having the same subcellular localization. The ZmSOD promoters contained 2-10 stress-responsive cis-elements with different distributions. Heatmap analysis indicated that ZmSODs were expressed in most of the detected tissues and organs. The expression patterns of ZmSODs were investigated under drought and salt treatments by qRT-PCR, and most members were responsive to drought or salt stress, especially some ZmSODs with significant expression changes were identified, such as ZmCSD2 and ZmMSD2, suggesting the important roles of ZmSODs in abiotic stress responses. Our results provide an important basis for further functional study of ZmSODs in future study.
DOI: 10.6084/m9.figshare.19923137
title: Regorafenib Suppresses Migration of and Induces Cell Cycle Arrest and Apoptosis in MCF-7 Cells

description: This study investigated the mechanism underlying the suppression of estrogen receptor-positive MCF-7 cell growth by regorafenib. MCF-7 cells were treated with regorafenib, and the effect of regorafenib on multiple cancer-associated pathways was evaluated. Although regorafenib effectively inhibited the proliferation of MCF-7 cells, it had no effect on the proliferation of the normal breast epithelial cell line MCF10A. Regorafenib suppressed MCF-7 cell migration, probably by regulating the homeostatic expression of matrix metalloproteinases and the tissue inhibitor of MMPs. Furthermore, it upregulated p21 expression, downregulated cyclin B1 and cyclin D1 expresssions, and caused cell cycle arrest. In addition, regorafenib induced apoptosis in MCF-7 cells by reducing Mcl-1 expression and activating caspase signaling. These results demonstrate that regorafenib has the potential to be an effective drug for treating breast cancer
DOI: 10.6084/m9.figshare.19923137.v1
title: Regorafenib Suppresses Migration of and Induces Cell Cycle Arrest and Apoptosis in MCF-7 Cells

description: This study investigated the mechanism underlying the suppression of estrogen receptor-positive MCF-7 cell growth by regorafenib. MCF-7 cells were treated with regorafenib, and the effect of regorafenib on multiple cancer-associated pathways was evaluated. Although regorafenib effectively inhibited the proliferation of MCF-7 cells, it had no effect on the proliferation of the normal breast epithelial cell line MCF10A. Regorafenib suppressed MCF-7 cell migration, probably by regulating the homeostatic expression of matrix metalloproteinases and the tissue inhibitor of MMPs. Furthermore, it upregulated p21 expression, downregulated cyclin B1 and cyclin D1 expresssions, and caused cell cycle arrest. In addition, regorafenib induced apoptosis in MCF-7 cells by reducing Mcl-1 expression and activating caspase signaling. These results demonstrate that regorafenib has the potential to be an effective drug for treating breast cancer
DOI: 10.6084/m9.figshare.19923222
title: The Effects of the Solvents on the Macrocyclic Structures: From Rigid Pillararene to Flexible Crown Ether

description: The differences in the macrocyclic structures lead to different flexibilities, and yet the effect of solvents on the conformations is not clear so far. In this work, the conformations of four representational macrocyclic molecules (pillar[5]arene, p-tert-butyl calix[6]arene, benzylic amide macrocycle and dibenzo-18-crown-6) in three solvents with distinct polarity have been studied by all-atom molecular dynamics simulations. The structural features of the macrocycles in the solvents indicate that the conformations are related to the polarity of the solvents and the formation of hydrogen bonds. For the pillar[5]arene, the benzylic amide macrocycle and the dibenzo-18-crown-6, that cannot form intramolecular hydrogen bonds, the polarity of solvents is the major contributing factor in the conformations. The formation of intramolecular hydrogen bonds, in contrast, determinates the conformations of the calix[6]arene. Furthermore, the slight fluctuations of the structures will result in tremendous change of the intramolecular hydrogen bonds of the macrocycles and the intermolecular hydrogen bonds between the macrocycles and the solvents. The current theoretical studies that serve as a basis for the macrocyclic chemistry are valuable for the efficient structural design of the macrocyclic molecules.
DOI: 10.6084/m9.figshare.19923222.v1
title: The Effects of the Solvents on the Macrocyclic Structures: From Rigid Pillararene to Flexible Crown Ether

description: The differences in the macrocyclic structures lead to different flexibilities, and yet the effect of solvents on the conformations is not clear so far. In this work, the conformations of four representational macrocyclic molecules (pillar[5]arene, p-tert-butyl calix[6]arene, benzylic amide macrocycle and dibenzo-18-crown-6) in three solvents with distinct polarity have been studied by all-atom molecular dynamics simulations. The structural features of the macrocycles in the solvents indicate that the conformations are related to the polarity of the solvents and the formation of hydrogen bonds. For the pillar[5]arene, the benzylic amide macrocycle and the dibenzo-18-crown-6, that cannot form intramolecular hydrogen bonds, the polarity of solvents is the major contributing factor in the conformations. The formation of intramolecular hydrogen bonds, in contrast, determinates the conformations of the calix[6]arene. Furthermore, the slight fluctuations of the structures will result in tremendous change of the intramolecular hydrogen bonds of the macrocycles and the intermolecular hydrogen bonds between the macrocycles and the solvents. The current theoretical studies that serve as a basis for the macrocyclic chemistry are valuable for the efficient structural design of the macrocyclic molecules.
DOI: 10.6084/m9.figshare.24716118
title: The influence of gas‒solid injector structural parameters(9-12) on injection performance

description: A gas‒solid injector acts as a power source in a pneumatic conveying system, and its structural parameters have a great influence on the injection and conveying performance of the system. This study uses a pure flow field experiment bed, a particle pneumatic injection experiment bed, and CFD‒DEM coupling simulation technology, as well as a gas‒solid injection experiment and gas‒solid coupling simulation datasets of gas‒solid injectors under four different particle mass flow rates, to present a pure flow field injection experiment and pure flow field simulation datasets of gas‒solid injectors with different structural parameters in the absence of particles. We evaluate the injection performance of gas‒solid injectors through the injection ratio, average pressure, transport time, conveying ratio, energy increasing ratio, and total energy consumption ratio. This dataset has great value for engineers and designers, providing a reference for designing gas‒solid injectors and other pneumatic conveying devices.
DOI: 10.6084/m9.figshare.24716118.v1
title: The influence of gas‒solid injector structural parameters(9-12) on injection performance

description: A gas‒solid injector acts as a power source in a pneumatic conveying system, and its structural parameters have a great influence on the injection and conveying performance of the system. This study uses a pure flow field experiment bed, a particle pneumatic injection experiment bed, and CFD‒DEM coupling simulation technology, as well as a gas‒solid injection experiment and gas‒solid coupling simulation datasets of gas‒solid injectors under four different particle mass flow rates, to present a pure flow field injection experiment and pure flow field simulation datasets of gas‒solid injectors with different structural parameters in the absence of particles. We evaluate the injection performance of gas‒solid injectors through the injection ratio, average pressure, transport time, conveying ratio, energy increasing ratio, and total energy consumption ratio. This dataset has great value for engineers and designers, providing a reference for designing gas‒solid injectors and other pneumatic conveying devices.
DOI: 10.6084/m9.figshare.24716121
title: The influence of gas‒solid injector structural parameters(5-8) on injection performance

description: A gas‒solid injector acts as a power source in a pneumatic conveying system, and its structural parameters have a great influence on the injection and conveying performance of the system. This study uses a pure flow field experiment bed, a particle pneumatic injection experiment bed, and CFD‒DEM coupling simulation technology, as well as a gas‒solid injection experiment and gas‒solid coupling simulation datasets of gas‒solid injectors under four different particle mass flow rates, to present a pure flow field injection experiment and pure flow field simulation datasets of gas‒solid injectors with different structural parameters in the absence of particles. We evaluate the injection performance of gas‒solid injectors through the injection ratio, average pressure, transport time, conveying ratio, energy increasing ratio, and total energy consumption ratio. This dataset has great value for engineers and designers, providing a reference for designing gas‒solid injectors and other pneumatic conveying devices.
DOI: 10.6084/m9.figshare.24716121.v1
title: The influence of gas‒solid injector structural parameters(5-8) on injection performance

description: A gas‒solid injector acts as a power source in a pneumatic conveying system, and its structural parameters have a great influence on the injection and conveying performance of the system. This study uses a pure flow field experiment bed, a particle pneumatic injection experiment bed, and CFD‒DEM coupling simulation technology, as well as a gas‒solid injection experiment and gas‒solid coupling simulation datasets of gas‒solid injectors under four different particle mass flow rates, to present a pure flow field injection experiment and pure flow field simulation datasets of gas‒solid injectors with different structural parameters in the absence of particles. We evaluate the injection performance of gas‒solid injectors through the injection ratio, average pressure, transport time, conveying ratio, energy increasing ratio, and total energy consumption ratio. This dataset has great value for engineers and designers, providing a reference for designing gas‒solid injectors and other pneumatic conveying devices.
DOI: 10.6084/m9.figshare.24716328
title: The influence of gas‒solid injector structural parameters(13-16) on injection performance

description: A gas‒solid injector acts as a power source in a pneumatic conveying system, and its structural parameters have a great influence on the injection and conveying performance of the system. This study uses a pure flow field experiment bed, a particle pneumatic injection experiment bed, and CFD‒DEM coupling simulation technology, as well as a gas‒solid injection experiment and gas‒solid coupling simulation datasets of gas‒solid injectors under four different particle mass flow rates, to present a pure flow field injection experiment and pure flow field simulation datasets of gas‒solid injectors with different structural parameters in the absence of particles. We evaluate the injection performance of gas‒solid injectors through the injection ratio, average pressure, transport time, conveying ratio, energy increasing ratio, and total energy consumption ratio. This dataset has great value for engineers and designers, providing a reference for designing gas‒solid injectors and other pneumatic conveying devices.
DOI: 10.6084/m9.figshare.24716328.v1
title: The influence of gas‒solid injector structural parameters(13-16) on injection performance

description: A gas‒solid injector acts as a power source in a pneumatic conveying system, and its structural parameters have a great influence on the injection and conveying performance of the system. This study uses a pure flow field experiment bed, a particle pneumatic injection experiment bed, and CFD‒DEM coupling simulation technology, as well as a gas‒solid injection experiment and gas‒solid coupling simulation datasets of gas‒solid injectors under four different particle mass flow rates, to present a pure flow field injection experiment and pure flow field simulation datasets of gas‒solid injectors with different structural parameters in the absence of particles. We evaluate the injection performance of gas‒solid injectors through the injection ratio, average pressure, transport time, conveying ratio, energy increasing ratio, and total energy consumption ratio. This dataset has great value for engineers and designers, providing a reference for designing gas‒solid injectors and other pneumatic conveying devices.
DOI: 10.6084/m9.figshare.19923267
title: Additional file 2 of Regulatory mechanism of Haa1p and Tye7p in Saccharomyces cerevisiae when fermenting mixed glucose and xylose with or without inhibitors

description: Additional file 2: Table S3. The genes regulated by the potential TFs in C_H vs. C_S (13), C_T vs. C_S (20), AFur_H vs. AFur_S (8), and AFur_T vs. AFur_S (5) groups. The light yellow highlighted values are calculated by DEGs/genes (the number of the DEGs regulated by the TFs to the number of the genes regulated by the TFs) or DEGs/all the DEGs (the number of the DEGs regulated by the TFs to all the DEGs in each group). The green highlighted genes are the DEGs that regulated by the TFs.
DOI: 10.6084/m9.figshare.19923267.v1
title: Additional file 2 of Regulatory mechanism of Haa1p and Tye7p in Saccharomyces cerevisiae when fermenting mixed glucose and xylose with or without inhibitors

description: Additional file 2: Table S3. The genes regulated by the potential TFs in C_H vs. C_S (13), C_T vs. C_S (20), AFur_H vs. AFur_S (8), and AFur_T vs. AFur_S (5) groups. The light yellow highlighted values are calculated by DEGs/genes (the number of the DEGs regulated by the TFs to the number of the genes regulated by the TFs) or DEGs/all the DEGs (the number of the DEGs regulated by the TFs to all the DEGs in each group). The green highlighted genes are the DEGs that regulated by the TFs.
DOI: 10.6084/m9.figshare.19923289
title: Additional file 1 of Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases

description: Additional file 1: Supplementary table 1. Spreadsheet including matched regimens used in 22 patients with LM.
DOI: 10.6084/m9.figshare.19923295
title: Additional file 3 of Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases

description: Additional file 3. Spreadsheet including non-matched regimens used in 59 patients with LM.
DOI: 10.6084/m9.figshare.19923295.v1
title: Additional file 3 of Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases

description: Additional file 3. Spreadsheet including non-matched regimens used in 59 patients with LM.
DOI: 10.6084/m9.figshare.19923289.v1
title: Additional file 1 of Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases

description: Additional file 1: Supplementary table 1. Spreadsheet including matched regimens used in 22 patients with LM.
DOI: 10.6084/m9.figshare.13107588.v1
title: Additional file 5 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 5. Significantly differentially expressed (SDE) novel chicken miRNA in DCs induced by H9N2 AIV infection. Thirty-six novel miRNAs were found to be significantly differentially expressed between H9N2-infected and mock-infected DCs
DOI: 10.6084/m9.figshare.13107585
title: Additional file 4 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 4. MiRNA profile of H9N2-infected and mock-infected DCs. In total, 994 known and 9208 novel miRNAs were identified in all samples.
DOI: 10.6084/m9.figshare.13107594
title: Additional file 7 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 7. GO terms for biological process enriched by the predicted target genes from SDE miRNAs. GO enrichment analysis revealed 180 biological processes were significantly (p-value &lt; 0.05) enriched by target genes, and the 27 terms associated with immune responses were marked in bold.
DOI: 10.6084/m9.figshare.13107594.v1
title: Additional file 7 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 7. GO terms for biological process enriched by the predicted target genes from SDE miRNAs. GO enrichment analysis revealed 180 biological processes were significantly (p-value &lt; 0.05) enriched by target genes, and the 27 terms associated with immune responses were marked in bold.
DOI: 10.6084/m9.figshare.13107597
title: Additional file 8 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 8. KEGG pathway annotations for the predicted target genes from SDE miRNAs.
DOI: 10.6084/m9.figshare.13107597.v1
title: Additional file 8 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 8. KEGG pathway annotations for the predicted target genes from SDE miRNAs.
DOI: 10.6084/m9.figshare.13107600
title: Additional file 9 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 9. Primers used to detect miRNA and target mRNA expression levels with quantitative RT-PCR.
DOI: 10.6084/m9.figshare.13107588
title: Additional file 5 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 5. Significantly differentially expressed (SDE) novel chicken miRNA in DCs induced by H9N2 AIV infection. Thirty-six novel miRNAs were found to be significantly differentially expressed between H9N2-infected and mock-infected DCs
DOI: 10.6084/m9.figshare.13107591
title: Additional file 6 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 6. Predicted targets for SDE miRNAs. Using RNAhybrid and miRanda software, 13503 target genes were predicted for SDE miRNAs, and one mRNA was targeted by many miRNAs and vice versa.
DOI: 10.6084/m9.figshare.13107591.v1
title: Additional file 6 of Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

description: Additional file 6. Predicted targets for SDE miRNAs. Using RNAhybrid and miRanda software, 13503 target genes were predicted for SDE miRNAs, and one mRNA was targeted by many miRNAs and vice versa.