cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22015094
title: Supplementary Material for: Relationship between Eosinophilic and Neutrophilic Inflammation in Chinese Chronic Rhinosinusitis with Nasal Polyps

description: <b><i>Introduction:</i></b> Chronic rhinosinusitis with nasal polyps (CRSwNPs) in China is characterized by a mixed eosinophilic-neutrophilic inflammation, linking to a more heterogeneous clinical phenotype. However, the relationship between eosinophilic and neutrophilic inflammation in Chinese patients with CRSwNP remains largely unknown. We aimed to further characterize the correlation between neutrophils with eosinophils in relation to clinical characters and disease control status after endoscopic sinus surgery (ESS). <b><i>Methods:</i></b> A total of 242 patients were recruited and stratified based on tissue (≥10%) eosinophilia and (≥20/per high-power field) neutrophilia. Clinical characteristics and disease control status were compared between subgroups. Associations between tissue eosinophils and neutrophils were analyzed. <b><i>Results:</i></b> The uncontrolled patients accounted for 41.3%, 41.3%, 17.1%, and 22.2% in subjects with concomitant tissue eosinophilia and neutrophilia (EN-high), isolated eosinophilia (E-high), isolated neutrophilia (N-high), and no eosinophilia and neutrophilia (EN-low), respectively. Positive correlations between tissue eosinophils and neutrophils were observed in patients with CRSwNP as well as in EN-high and N-high subgroups but not in E-high and EN-low subgroups. The EN-high subgroup had higher tissue eosinophil numbers than the other three subgroups. Both EN-high and E-high subgroups had higher rates of uncontrolled subjects than the N-high and EN-low subgroups; however, there was no difference in the rate of uncontrolled subjects between EN-high and E-high subgroups and between N-high and EN-low subgroups. <b><i>Conclusion:</i></b> Tissue neutrophils might have a potential interaction and mutual promotion effect with eosinophils in CRSwNP. However, tissue neutrophilia would not pose significant risk for poor disease control after ESS. Further larger, prospective studies are needed to confirm our findings.
DOI: 10.6084/m9.figshare.22040915
title: Supplementary Material for: Early versus delayed minimally invasive intervention for acute necrotizing pancreatitis: An updated systematic review and meta-analysis

description: Background: Nowadays, minimally invasive intervention (MII) has largely replaced delayed open surgery in acute necrotizing pancreatitis (ANP). However, the timing of MII remains unclear. The present study investigated the effect of early versus delayed MII on complications in ANP. Methods: Studies evaluating the impact of the timing of MII on complications in ANP patients were thoroughly searched on PubMed, EMBASE, Cochrane Library, and Web of Science from inception to June 2022. The primary outcome of interest was mortality. Secondary outcomes were the incidence of complications. Results: Nine studies reporting 870 patients undergoing MII for ANP were included. No significant difference was found in mortality between the early and delayed intervention groups. In addition, the timing of MII was not associated with the incidence of new-onset respiratory failure, new-onset cardiovascular failure, new-onset renal failure, new-onset multiple organ failure, gastrointestinal fistula or perforation, pancreatic fistula, stent migration, bleeding, venous thrombosis, and new-onset pancreatic endocrine insufficiency. Notably, in the subgroup analysis of biliary and Asian ANP patients, early intervention was associated with a significantly higher risk of new-onset renal failure than delayed intervention. Conclusions: Early intervention is safe and recommended only for patients with indications for intervention, such as infection.
DOI: 10.6084/m9.figshare.22353562
title: Supplementary Material for: A Rare Microsporidial Infection in Lamellar Corneal Tissue, Following Transepithelial Photorefractive Keratectomy

description: To report a unique case of microsporidial keratitis over deep anterior lamellar keratoplasty after Trans-PRK surgery that was successfully treated with therapeutic lamellar keratoplasty without recurrence at King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia. The patient presented with recurrent attacks of eye pain, redness, photophobia, and decrease vision. The patient was initially treated as a case of presumed herpetic keratouveitis using antiviral medication and topical steroids with partial improvement. During the last episode, the condition deteriorated and patient underwent therapeutic lamellar keratoplasty. Histopathology indicated an infected graft with evidence of microsporidial infection. The patient was discharged with complete corneal epithelial healing, and no signs of recurrence during follow-up. Microsporidial infection is a rare cause of stromal keratitis that affects both immunocompetent and immunosuppressed patients. Microsporidia should be suspected after surface ablation refractive surgery if the patient presents with recurrent symptoms of keratoconjunctivitis or stromal keratitis that is partially responsive to topical steroid therapy.
DOI: 10.6084/m9.figshare.22567015
title: Supplementary Material for: Frequency of and factors associated with the presence of a history of probable ADHD in a population of patients with sex addiction

description: Introduction: Since the first description of sex addiction (SA) by Carnes, research on this problematic behaviour has continued to grow, and the association with attention-deficit hyperactivity disorder (ADHD) appears to be frequent. This study aimed to estimate the frequency of a history of probable ADHD in a population of patients with SA and to explore the factors associated with it. Methods: One hundred eighty-five patients referred to the Nantes University Hospital for SA between 2011 and 2020 were included. Patients completed the Sexual Addiction Screening Test (SAST) or its revised version (SAST-R) to establish the presence of SA. As the SAST-R was not validated in French, we conducted a validation study for the French version. ADHD was screened using the Wender-Utah Rating Scale in childhood and the Adult-ADHD Self-Report Scale in adulthood. A multivariate logistic regression model was used to identify factors associated with the presence of a history of probable ADHD. Results: Childhood ADHD was identified in 36% of patients with SA. Factors associated with the presence of a history of probable ADHD were a low education level, an earlier age of onset of problematic sexual behaviour, another addictive disorder, an anxiety disorder, impulsivity (high negative urgency score) and high scores on harm avoidance and novelty-seeking temperament scales. Furthermore, the French version of the SAST-R displayed good psychometric properties, especially excellent sensitivity. Discussion/Conclusion: The frequency of a history of probable ADHD among patients with SA is consistent with the literature and close to the highest range. Specific personality traits in patients with both SA and a history of probable ADHD could induce lasting problems of adaptation, which may precipitate the development of SA or maintain it.
DOI: 10.6084/m9.figshare.22598032
title: Supplementary Material for: Haemodynamic gain index is associated with risk of sudden cardiac death and improves risk prediction: a cohort study

description: Introduction: Haemodynamic gain index (HGI) is a novel haemodynamic parameter which can be obtained from cardiopulmonary exercise testing (CPX), but its association with sudden cardiac death (SCD) is not known. We aimed to assess the association of HGI with SCD risk in a long-term prospective cohort study. Methods: Haemodynamic gain index was calculated using heart rate and systolic blood pressure (SBP) measured in 1897 men aged 42-61 years during CPX from rest to peak exercise, using the formula: [(Heart rate max x SBPmax) - (Heart rate rest x SBPrest)]/(Heart rate rest x SBPrest). Cardiorespiratory fitness (CRF) was measured using respiratory gas exchange analysis. Multivariable adjusted hazard ratios (HRs) (95% confidence intervals, CIs) were analyzed for SCD. Results: During a median follow-up of 28.7 years, 205 SCDs occurred. The risk of SCD decreased gradually with increasing HGI (p-value for non-linearity=.63). A unit (bpm/mmHg) higher HGI was associated with a decreased risk of SCD (HR 0.84; 95% CI 0.71–0.99), which was attenuated following adjustment for CRF. Cardiorespiratory fitness was inversely associated with SCD, which remained after further adjustment for HGI: (HR 0.85; 95% CI 0.77–0.94) per each unit higher CRF. Addition of HGI to a SCD risk prediction model containing established risk factors improved risk discrimination (C-index change=0.0096; p=.017) and reclassification (NRI=39.40%, p=.001). The corresponding values for CRF were (C-index change=0.0178; p=.007) and (NRI=43.79%, p=.001). Conclusion: Higher HGI during CPX is associated with a lower SCD risk, consistent with a dose-response relationship, but dependent on CRF levels. Though HGI significantly improves the prediction and classification of SCD beyond common cardiovascular risk factors, CRF remains a stronger risk indicator and predictor of SCD compared to HGI.
DOI: 10.6084/m9.figshare.22652233
title: Supplementary Material for: Intraocular spread of ocular surface squamous neoplasia presenting as a postoperative anterior chamber opacity after excisional biopsy

description: We describe a rare case of ocular surface squamous neoplasia (OSSN) with intraocular spread after excisional biopsy which presented as a postoperative anterior chamber (A/C) opacity, initially thought to be a hypopyon. A 60-year-old female with history of a right (OD) conjunctival mass involving the cornea, surgically excised and diagnosed as OSSN, presented two months postoperatively with an A/C opacity concerning for infection. The patient was prescribed prednisolone acetate and ofloxacin drops postoperatively; topical chemotherapy was not given. When the opacity did not respond to three weeks of topical treatment, they were referred to an ocular oncologist for management. Intraoperative records from biopsy were unavailable; use of cryotherapy is unknown. On presentation, patient had reduced vision OD. On slit lamp exam, a white plaque in the A/C was seen, obscuring the iris. Given concern for postoperative intraocular cancer spread and extent of disease, enucleation with extended conjunctival excision was done. Gross pathology revealed an A/C mass with a diffuse hazy membrane. Histopathology diagnosed moderately differentiated OSSN with extensive intraocular invasion; a full-thickness limbal defect was visualized. Disease was confined to the globe, without residual conjunctival malignancy. This case emphasizes the importance of taking surgical precaution when excising conjunctival lesions, especially large lesions which obscure ocular anatomy, to maintain scleral integrity and Bowman’s layer with limbal lesions. Intraoperative cryotherapy and postoperative chemotherapy should also be employed. If a patient with history of ocular surface malignancy displays symptoms concerning for postoperative infection, this case highlights the importance of considering invasive disease.
DOI: 10.6084/m9.figshare.23536245
title: Supplementary Material for: Early detection of isolated severe congenital heart defects is associated with a lower threshold to terminate the pregnancy

description: Objective: Early detection of isolated severe congenital heart defects (CHDs) allows extra time for chromosomal analysis and informed decision making, resulting in improved perinatal management and patient satisfaction. The aim of this study was to assess the value of an additional first trimester scan compared to only a second trimester scan in fetuses diagnosed with isolated severe CHDs. Prenatal detection rates, time of prenatal diagnosis and pregnancy outcomes were evaluated in the Netherlands after implementation of a national screening program. Methods: We performed a retrospective geographical cohort study and included 264 pre- and postnatally diagnosed isolated severe CHD cases between 01-01-2007 and 31-12-2015 in the Amsterdam region. Two groups were defined: a first- and second trimester anomaly scan (Group 1), only a second trimester anomaly scan only (Group 2). A first trimester scan was defined as a scan between 11+0 and 13+6 weeks. Results: Overall, the prenatal detection rate for isolated severe CHDs was 65%, 63% were detected before 24 weeks of gestation (97% of all prenatally detected CHDs). Prenatal detection rate was 70.2% in the group with a first- and second trimester scan (Group 1) and 58% in the group with a second trimester scan only (Group 2) (p &lt;0.05). Median gestational age at detection was 19+6 (interquartile range (IQR) 15+4 - 20+5) in Group 1 versus 20+3 (IQR 20+0 - 21+1) in Group 2 (p &lt;0.001). In Group 1, 22% were diagnosed before 18 weeks of gestation. Termination of pregnancy rates in Group 1 and Group 2 were 48% and 27%, respectively (p &lt;0.01). Median gestational age at termination did not differ between the two groups. Conclusion: Prenatal detection rates of isolated severe CHD and termination of pregnancy rates were higher in the group with a first- and second trimester scan. We found no differences between timing of terminations. The additional time after diagnosis allows for genetic testing and for optimal counselling of expectant parents regarding prognosis and perinatal management so that well-informed decisions can be made.
DOI: 10.6084/m9.figshare.23579745
title: Supplementary Material for: Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis

description: <b><i>Introduction:</i></b> To achieve early detection and curative treatment options, surveillance imaging for hepatocellular carcinoma (HCC) must remain of quality and without substantial limitations in liver visualization. However, the prevalence of limited liver visualization during HCC surveillance imaging has not been systematically assessed. Utilizing a systematic review and meta-analytic approach, we aimed to determine the prevalence of limited liver visualization during HCC surveillance imaging. <b><i>Methods:</i></b> MEDLINE and Embase electronic databases were searched to identify published data on liver visualization limitations of HCC surveillance imaging. An analysis of proportions was pooled using a generalized linear mixed model with Clopper-Pearson intervals. Risk factors were analysed using a generalized mixed model with a logit link and inverse variance weightage. <b><i>Results:</i></b> Of 683 records, 10 studies (7,131 patients) met inclusion criteria. Seven studies provided data on liver visualization limitations on ultrasound (US) surveillance exams: prevalence of limited liver visualization was 48.9% (95% CI: 23.5–74.9%) in the overall analysis and 59.2% (95% CI: 24.2–86.9%) in a sensitivity analysis for cirrhotic patients. Meta-regression determined that non-alcoholic fatty liver disease was associated with limited liver visualization on US. Four studies provided data for liver visualization limitations in abbreviated magnetic resonance imaging (aMRI), with inadequate visualization ranging from 5.8% to 19.0%. One study provided data for complete MRI and none for computed tomography. <b><i>Conclusion:</i></b> A substantial proportion of US exams performed for HCC surveillance provide limited liver visualization, especially in cirrhosis, which may hinder detection of small observations. Alternative surveillance strategies including aMRI may be appropriate for patients with limited US visualization.
DOI: 10.6084/m9.figshare.23600556.v1
title: Supplement 7

description: A heatmap showing the number of gene models annotations submitted for each gene/species combination.
DOI: 10.6084/m9.figshare.23721870
title: Retroreflected optical phase, angle-of-arrival, and intensity dataset

description: Simultaneous measurements of optical phase, angle-of-arrival, and intensity over a retroreflected optical link are provided for three different measurement trials. A Jupyter notebook used to analyse atmospheric turbulence conditions based on these measurements is also provided. A preprint for the accompanying paper may be found at: https://doi.org/10.1364/opticaopen.23735448 <br> The Jupyter notebook file 'turbulence_characterisation.ipynb' provides all code used for data analysis in the accompanying paper. <br> Three .h5 files are provided, each containing data corresponding to three different experimental measurements. Details of the experimental architecture and conditions for these three datasets may be found in the accompanying paper. - dataset_low.h5 - dataset_med.h5 - dataset_high.h5 Each file may be read using the 'pandas' python library. For example, pd.HDFStore('dataset_low.h5', 'r', complevel=1, complib='zlib') <br> Each file has the following hierarchical structure: - hdf [.h5 file] - hdf.phase - hdf.phase.t [measurement time in seconds] - hdf.phase.phase_rad [recorded optical phase in rad] - hdf.qpd - hdf.qpd.t [measurement time in seconds] - hdf.qpd.xdiff [x-axis difference voltage normalised to +-1] - hdf.qpd.ydiff [y-axis difference voltage normalised to +-1] - hdf.qpd.fpd_opt [received fibre-coupled optical power in W. Losses due to beam splitters have been corrected so that this measurement corresponds to the one below but with additional coupling loss.] - hdf.qpd.qpd_opt [received free-space optical power in W. Losses due to beam splitters have been corrected, this corresponds to the reflected light intensity incident on the front of the optical terminal.] - hdf.weather - hdf.weather.time [timestamp in local time] - hdf.weather.windspeed_avg [average windspeed in m/s] - hdf.weather.windspeed_gust [maximum windspeed in m/s] - hdf.weather.temp [ambient temp in m/s] - hdf.weather.t [measurement time in seconds] <br>
DOI: 10.6084/m9.figshare.23884830
title: Supplementary Material for: Systolic blood pressure and the risk of kidney replacement therapy and mortality in patients with chronic kidney disease stage 4-5

description: Introduction In patients with chronic kidney disease stage 4 and 5 (CKD stages 4-5) without dialysis and arterial hypertension, it is unknown if the values of systolic blood pressure (SBP) considered in control &lt;120 mmHg are associated with kidney replacement therapy (KRT) and mortality. Methods In this retrospective cohort study, hypertensive CKD stages 4-5 patients attending the Renal Health Clinic at the Hospital Civil de Guadalajara were enrolled. We divided them into those that achieved SBP &lt; 120 mmHg (controlled group) and those who did not (&gt;120 mmHg), the uncontrolled group. Our primary objective was to analyze the association between the controlled group and KRT; the secondary objective was the mortality risk, and if there were subgroups of patients that achieved more benefit. Data were analyzed using Stata software, version. 15.1. Results During 2017 to 2022 a total 275 hypertensive CKD stages 4-5 patients met the inclusion criteria for the analysis, 62 in the controlled group and 213 in the uncontrolled group; mean age 61 years, 49.82% were male, SBP was significantly lower in the controlled group (111 mmHg) compared to the uncontrolled group (140 mmHg), eGFR was similar between groups (20.41 ml/min/1.73m2). There was a tendency to increase the mortality risk in the uncontrolled group (HR 6.47 [0.78-53.27]; p= 0.082) and an association by the Kaplan-Meir analysis (Log-rank p= 0.043). The subgroup analysis for risk of KRT in the controlled group revealed that patients ≥ 61 years had a lower risk of KRT (HR 0.87 [95% CI, 0-76-0.99]; p=0.03, p of interaction = 0.005), but no differences were found in the subgroup analysis for mortality. In a follow-up of 1.34 years, no association was found in the risk of KRT according to the controlled or uncontrolled groups in a multivariate Cox analysis. Conclusion In a retrospective cohort of patients with CKD stages 4-5 and hypertension, SBP &gt;120 mmHg was not associated with risk of KRT but could be associated with the risk of death. Clinical trials are required in this group of patients to demonstrate the impact of reaching the SBP goals recommended by the KDIGO guidelines.
DOI: 10.6084/m9.figshare.24236344
title: Supplementary Material for: Inflammatory myofibroblastic tumor in the adrenal gland: a case report

description: Inflammatory myofibroblastic tumors (IMT) were first described by Harold Brunn in 1939. IMTs are mainly found in the lungs and other sites of the body; hence, its occurrence in the adrenal gland is exceptional. In the literature, less than 10 cases of IMTs in the adrenal gland have been reported. The etiology of IMT remains unknown, with post-inflammatory changes and a neoplastic origin being proposed. We present a case of a 19-year-old woman and adrenal gland IMT. The patient presented with abdominal pain and low cardiac output without hypovolemic shock. Computed tomography (CT) revealed a tumor in the adrenal gland measuring 11.4 cm with extravasation of contrast medium within the tumor. Treatment included conservative management with selective embolization due to minimal invasion of the inferior artery of the adrenal gland. The patient was then discharged with possibility of future elective surgery. Four months later, the size of the tumor decreased to 6.3 cm, and her Eastern Cooperative Oncology Group physical status was 0. The Multidisciplinary Tumor Board suggested surgical management. The final histopathology report was compatible with an IMT of the adrenal gland, with the immunohistochemical report showing positivity for AAME anti-actin muscle-specific and anti-actin smooth muscle and negativity for anaplastic lymphoma kinase. IMTs of the adrenal gland may be treated electively through multidisciplinary management together with interventional radiology and surgery, achieving a favorable outcome for the patient.
DOI: 10.17632/w9hsj2whzm.1
title: Energy envelope data for seismic attenuation study of the Gargano Promontory (Southern Italy) and surrounding regions

description: The dataset includes the seismic energy envelopes used to study the coda attenuation Qc quality factor in the Gargano Promontory (Southern Italy) and surrounding regions (Filippucci et al., 2019; 2021). The seismic energy envelopes are band pass filtered (Butterworth, two-poles) in frequency bands with central frequency fc= 2, 3, 4, 5, 6, 8, 10, 12, 14 and 16 Hz, with a bandwidth ranging inside the interval [fc/√2; fc*√2]. Seismic envelopes are already cut in the time window of the descending energy, ready to be fitted in order to compute the seismic energy attenuation of the sampled medium. In order to reproduce the results of the Qc study (Filippucci et al., 2019; 2021) a single scattering model (Aki, 1969) should be used. - For earthquakes occurred from June to September 2013 the folder is Seismic_Envelopes_2013.zip. In this compressed folder, the seismic event folders are collected named with a numerical code indicating year, month, day, hour, minute of the event origin time (format AAAAMMDDHHmm). In each event folder, the seismic envelope files in *.dat format. - For earthquakes occurred from July 2015 to August 2018 the folder is Seismic_Envelopes_2015_2018.zip. In this compressed folder, the seismic event folders are collected named with a numerical code indicating year, month, day, hour, minute of the event origin time (format AAAAMMDDHHmm). In each event folder, the seismic envelope files in *.TXT format. The original seismograms together with the event's location and magnitude, station locations and velocity model have been already published (https://data.mendeley.com/datasets/7b5mmdjpt3/5).