cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19923348
title: Profile of pharmaceutical care in primary health centers in São Bernardo do Campo, Southeastern Brazil

description: The effective insertion of the pharmacist into primary care is an important goal for health policies. The objective of this study was to describe and analyze pharmacists and Pharmaceutical Care in the primary health centers (UBS) of São Bernardo do Campo. Data were obtained through an interview applied to pharmacists. The instrument has three sections: (1) Pharmacist identification; (2) Pharmacist work; and (3) Pharmaceutical activities. Items in section 3 correspond to the guidelines of agencies that promote Pharmaceutical Care in the primary health system. All 24 pharmacists working in UBS in São Bernardo do Campo were interviewed. Every center dispensing medicines has a responsible pharmacist. These pharmacists are predominantly women and postgraduates. Activities of Pharmaceutical Care reported were: daily prescription analysis (75% of interviewees); monthly participation in patient groups (70.8%); monthly follow-up of pharmacotherapy adherence (58.3%); monthly participation in multiprofessional team meetings (54.2%); monthly home visits (12.5%); health education to the community (83.3%); and pharmacist consultation (37.5%). Frequency of prescription analysis and home visits was weakly associated with aspects of the pharmacist and the facility. This study showed that Pharmaceutical Services are structured in primary care in São Bernardo do Campo and many Pharmaceutical Care activities are offered in its UBS
DOI: 10.6084/m9.figshare.19923348.v1
title: Profile of pharmaceutical care in primary health centers in São Bernardo do Campo, Southeastern Brazil

description: The effective insertion of the pharmacist into primary care is an important goal for health policies. The objective of this study was to describe and analyze pharmacists and Pharmaceutical Care in the primary health centers (UBS) of São Bernardo do Campo. Data were obtained through an interview applied to pharmacists. The instrument has three sections: (1) Pharmacist identification; (2) Pharmacist work; and (3) Pharmaceutical activities. Items in section 3 correspond to the guidelines of agencies that promote Pharmaceutical Care in the primary health system. All 24 pharmacists working in UBS in São Bernardo do Campo were interviewed. Every center dispensing medicines has a responsible pharmacist. These pharmacists are predominantly women and postgraduates. Activities of Pharmaceutical Care reported were: daily prescription analysis (75% of interviewees); monthly participation in patient groups (70.8%); monthly follow-up of pharmacotherapy adherence (58.3%); monthly participation in multiprofessional team meetings (54.2%); monthly home visits (12.5%); health education to the community (83.3%); and pharmacist consultation (37.5%). Frequency of prescription analysis and home visits was weakly associated with aspects of the pharmacist and the facility. This study showed that Pharmaceutical Services are structured in primary care in São Bernardo do Campo and many Pharmaceutical Care activities are offered in its UBS
DOI: 10.6084/m9.figshare.19923351
title: Dental displacement in complete dentures influenced by different flask types and polymerization cycles

description: Abstract This study evaluated the dental displacement in dentures included in different flasks and processed by the Australian cycle modified or by microwave. Metal pins were placed on the teeth as reference for measurements: a) Incisal edge of maxillary and mandibular central incisors, buccal cusp of maxillary and mandibular vestibular first premolars, and mesiobuccal maxillary and mandibular cusps of second molars; b) Incisor to incisor, premolar to premolar and molar to molar; c) Left incisor to left molar and right incisor to right molar, and d) Vertical. Dentures were divided according to flasks (n=10): G1- Metal; G2- HH bimaxillary metal; G3-Microwaves; G4- HH bimaxillary microwaves. For G1 and G2, polymerization at 65ºC/30 min, flame quenched for 30 min, heating at 65ºC/30 min, boiling water for 1 h. For G3 and G4, microwave (20 min/140 W and 5 min/560 W). Comparator microscope with digital camera and analytical unit assessed the measurements before and after denture polymerization. The final distance was made subtracting the distance before the denture processing from the distance of the dental displacement after processing. The value of the difference was submitted to 2-way ANOVA, considering the flask type and denture type. Maxillary denture showed greater displacement when compared to mandibular denture. Flask types and interaction with denture types showed similar difference between before and after polymerization. In conclusion, displacement promoted by flask types in dentures cured by polymerization cycles promoted similar effect on the distance between teeth. Greater value for distance between teeth occurred for maxillary denture.
DOI: 10.6084/m9.figshare.19918858
title: palla2021squidpy_Slide-seqV2_Mouse_Cortex

description: palla2021squidpy_Slide-seqV2_Mouse_Cortex.h5ad
DOI: 10.6084/m9.figshare.19923353
title: Kangaroo Method: potentialities, barriers and difficulties in humanized care for newborns in the Neonatal ICU

description: ABSTRACT Objective: To identify the potentialities, barriers and difficulties for the implementation of humanized care from the perspective of the Kangaroo Method. Methods: Integrative literature review with a time cut from 02/01/2015 to 06/01/2019, totaling ten articles in the final sample. Results: The findings were categorized into two categories: Potentialities for humanized care from the perspective of the Kangaroo Method; Barriers or difficulties to the implementation of the Kangaroo Method. Several potentialities for humanized care allied to technology and continuing education were identified, as well as several barriers to the implementation of the Kangaroo Method, such as lack of physical space, lack of professionals and team training, lack of knowledge, lack of adherence and professional demotivation. Final considerations: There are still few studies that address the potentialities, barriers and difficulties for the implementation of humanized care from the perspective of the Kangaroo Method, and most of those included in this review were conducted in Brazil and present a qualitative approach.
DOI: 10.6084/m9.figshare.19923353.v1
title: Kangaroo Method: potentialities, barriers and difficulties in humanized care for newborns in the Neonatal ICU

description: ABSTRACT Objective: To identify the potentialities, barriers and difficulties for the implementation of humanized care from the perspective of the Kangaroo Method. Methods: Integrative literature review with a time cut from 02/01/2015 to 06/01/2019, totaling ten articles in the final sample. Results: The findings were categorized into two categories: Potentialities for humanized care from the perspective of the Kangaroo Method; Barriers or difficulties to the implementation of the Kangaroo Method. Several potentialities for humanized care allied to technology and continuing education were identified, as well as several barriers to the implementation of the Kangaroo Method, such as lack of physical space, lack of professionals and team training, lack of knowledge, lack of adherence and professional demotivation. Final considerations: There are still few studies that address the potentialities, barriers and difficulties for the implementation of humanized care from the perspective of the Kangaroo Method, and most of those included in this review were conducted in Brazil and present a qualitative approach.
DOI: 10.6084/m9.figshare.19923354
title: Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines

description: Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties
DOI: 10.6084/m9.figshare.19923354.v1
title: Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines

description: Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties
DOI: 10.6084/m9.figshare.19922942
title: Introduction to path-integral Quantum Field Theory – A toolbox

description: Lecture notes on path-integrals, suitable for an undergraduate course with prerequisites such as: Classical Mechanics, Electromagnetism and Quantum Mechanics. The aim is to provide the reader, who is familiar with the major concepts of Solid State Physics, to study these topics couched in the language of path integrals. We endeavor to keep the formalism to the bare minimum.
DOI: 10.6084/m9.figshare.19923359
title: Analysis of the applicative potential of pigments extracted from bacterial isolates of mangrove soil as topical UV protectants

description: Antioxidant, antibacterial and UV protective activities of two pigments extracted from mangrove soil isolates were analysed for their applications as ingredients in sunscreen formulations. Through biochemical characterization, the isolates were tentatively identified as belonging to the Flavobacterium sp. and Brevibacterium sp. UV visible spectral characterization of the pigments indicated presence of carotenoids. The orange pigment exhibited Sun Protection factor (SPF) value of 5.3 while the yellow pigment SPF was found to be 2.60. Both isolates as well as their pigments revealed tolerance to UVA-B radiation and to UVC radiation, to comparatively lesser extent. Yellow pigment exhibited good antibacterial activity with maximum effect on Escherichia coli, Corynebacterium diptheriae and Staphylococcus aureus. Both pigments were capable of reducing DPPH radical with % DPPH inhibition of 52.36% (orange pigment) and 40.1% (yellow pigment). These findings suggest that both pigments show promise of making excellent natural components of cosmetic formulations, especially sunscreens.
DOI: 10.6084/m9.figshare.19922942.v1
title: Introduction to path-integral Quantum Field Theory – A toolbox

description: Lecture notes on path-integrals, suitable for an undergraduate course with prerequisites such as: Classical Mechanics, Electromagnetism and Quantum Mechanics. The aim is to provide the reader, who is familiar with the major concepts of Solid State Physics, to study these topics couched in the language of path integrals. We endeavor to keep the formalism to the bare minimum.
DOI: 10.6084/m9.figshare.19923359.v1
title: Analysis of the applicative potential of pigments extracted from bacterial isolates of mangrove soil as topical UV protectants

description: Antioxidant, antibacterial and UV protective activities of two pigments extracted from mangrove soil isolates were analysed for their applications as ingredients in sunscreen formulations. Through biochemical characterization, the isolates were tentatively identified as belonging to the Flavobacterium sp. and Brevibacterium sp. UV visible spectral characterization of the pigments indicated presence of carotenoids. The orange pigment exhibited Sun Protection factor (SPF) value of 5.3 while the yellow pigment SPF was found to be 2.60. Both isolates as well as their pigments revealed tolerance to UVA-B radiation and to UVC radiation, to comparatively lesser extent. Yellow pigment exhibited good antibacterial activity with maximum effect on Escherichia coli, Corynebacterium diptheriae and Staphylococcus aureus. Both pigments were capable of reducing DPPH radical with % DPPH inhibition of 52.36% (orange pigment) and 40.1% (yellow pigment). These findings suggest that both pigments show promise of making excellent natural components of cosmetic formulations, especially sunscreens.
DOI: 10.6084/m9.figshare.19923360
title: Preparation, Spectral Characterization and Anticancer Potential of Cinnamic Esters

description: Cinnamic acid and its derivatives show a remarkable variety of biological activities and are often studied in search of the development of new and highly effective drugs. This work aims to synthesize, characterize and evaluate the cytotoxic activity of esters derived from cinnamic acid. Eighteen esters were synthesized through Steglich’s esterification, of which eleven were not reported in the literature. All compounds were fully characterized by Fourier transform infrared epectroscopy (FTIR), nuclear magnetic resonance (1H and 13C NMR) and high-resolution mass spectrometry (HRMS) data. The cytotoxic activity of esters obtained was evaluated using four human tumor cell lines: SNB-19 (astrocytoma), HCT-116 (colon carcinoma, human), PC3 (prostate) and HL60 (promyelocytic leukemia) through the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium (MTT) colorimetric assay. These studies showed that the compound 3-methoxybenzyl (E)-3-(4-methoxyphenyl)acrylate (12) is the most potent against HCT-116, PC3 and SBN-19 cells, with the lowest half maximal inhibitory concentration (IC50) value of 16.2 µM in the HCT-116 strain. The derivatives were obtained in good yields (76.6-95%), except for compounds 5-isopropyl-2-methylphenyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (17) (18.6%) and 2-isopropyl-5-methylphenyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (18) (15.5%).
DOI: 10.6084/m9.figshare.19920674
title: Scorpion species of medical importance in the Brazilian Amazon: a review to identify knowledge gaps

description: Abstract Scorpionism is a relevant medical condition in Brazil. It is responsible for most accidents involving venomous animals in the country, which leads to severe symptoms that can evolve to death. In recent years, an increase of almost 50% in the incidence of scorpionism has been observed in the Northern Region, where the highest severity of envenoming has been notified since the beginning of the 21st century. This review aims to provide an in-depth assessment of public data and reports on symptoms and epidemiology of envenoming, ecological aspects of scorpions, and characterization of venoms and toxins to access the gaps that need to be filled in the knowledge of the scorpion species of medical importance from the Brazilian Amazon. A systematic search using the string words “Amazon” and “scorpion” was performed on 11 databases. No restriction on date, language or status of the publication was applied. Reports not related to the Brazilian Amazon were excluded. Therefore, 88 studies remained. It is shown that populations of scorpions of medical importance, even of the same species, may present significant toxic variations peculiar to some regions in the Brazilian Amazon, and commercial scorpion antivenoms were not able to shorten the intensity and duration of neurological manifestations in patients stung by T. silvestris, T. apiacas or T. obscurus. It is also highlighted that the toxins responsible for triggering these alterations have not been elucidated yet and this is a fruitful field for the development of more efficient antivenoms. Furthermore, the geographic distribution of scorpions of the genus Tityus in the Brazilian Amazon was revised and updated. The cumulative and detailed information provided in this review may help physicians and scientists interested in scorpionism in the Brazilian Amazon.
DOI: 10.6084/m9.figshare.19920674.v1
title: Scorpion species of medical importance in the Brazilian Amazon: a review to identify knowledge gaps

description: Abstract Scorpionism is a relevant medical condition in Brazil. It is responsible for most accidents involving venomous animals in the country, which leads to severe symptoms that can evolve to death. In recent years, an increase of almost 50% in the incidence of scorpionism has been observed in the Northern Region, where the highest severity of envenoming has been notified since the beginning of the 21st century. This review aims to provide an in-depth assessment of public data and reports on symptoms and epidemiology of envenoming, ecological aspects of scorpions, and characterization of venoms and toxins to access the gaps that need to be filled in the knowledge of the scorpion species of medical importance from the Brazilian Amazon. A systematic search using the string words “Amazon” and “scorpion” was performed on 11 databases. No restriction on date, language or status of the publication was applied. Reports not related to the Brazilian Amazon were excluded. Therefore, 88 studies remained. It is shown that populations of scorpions of medical importance, even of the same species, may present significant toxic variations peculiar to some regions in the Brazilian Amazon, and commercial scorpion antivenoms were not able to shorten the intensity and duration of neurological manifestations in patients stung by T. silvestris, T. apiacas or T. obscurus. It is also highlighted that the toxins responsible for triggering these alterations have not been elucidated yet and this is a fruitful field for the development of more efficient antivenoms. Furthermore, the geographic distribution of scorpions of the genus Tityus in the Brazilian Amazon was revised and updated. The cumulative and detailed information provided in this review may help physicians and scientists interested in scorpionism in the Brazilian Amazon.
DOI: 10.6084/m9.figshare.19923360.v1
title: Preparation, Spectral Characterization and Anticancer Potential of Cinnamic Esters

description: Cinnamic acid and its derivatives show a remarkable variety of biological activities and are often studied in search of the development of new and highly effective drugs. This work aims to synthesize, characterize and evaluate the cytotoxic activity of esters derived from cinnamic acid. Eighteen esters were synthesized through Steglich’s esterification, of which eleven were not reported in the literature. All compounds were fully characterized by Fourier transform infrared epectroscopy (FTIR), nuclear magnetic resonance (1H and 13C NMR) and high-resolution mass spectrometry (HRMS) data. The cytotoxic activity of esters obtained was evaluated using four human tumor cell lines: SNB-19 (astrocytoma), HCT-116 (colon carcinoma, human), PC3 (prostate) and HL60 (promyelocytic leukemia) through the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium (MTT) colorimetric assay. These studies showed that the compound 3-methoxybenzyl (E)-3-(4-methoxyphenyl)acrylate (12) is the most potent against HCT-116, PC3 and SBN-19 cells, with the lowest half maximal inhibitory concentration (IC50) value of 16.2 µM in the HCT-116 strain. The derivatives were obtained in good yields (76.6-95%), except for compounds 5-isopropyl-2-methylphenyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (17) (18.6%) and 2-isopropyl-5-methylphenyl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate (18) (15.5%).
DOI: 10.6084/m9.figshare.19923362
title: Standard Jones and Modified Jones: An Earnings Management Tutorial

description: ABSTRACT Context: measurement of earnings management usually requires multi-step models for computation. After examining the literature through bibliometrics studies, literature review, and research databases, we found that the Standard Jones model and its subsequent modifications are those that have more prominent use. Much of this research is potentially interesting for business theories related to earnings quality and accounting manipulation; however, it is difficult to be understood by junior researchers and practitioners, because they are not clearly described in the literature or the steps may be easy to confuse. Objective: in this tutorial, we present several key concepts about earnings management and explain, step by step, how to measure it. Method: our tutorial considers measurement using the following models: Standard Jones, Modified Jones, Modified Jones with return on assets (ROA), and Modified Jones using Cash Flows and Accruals Reversals. Conclusions: our main contribution with this tutorial is to provide a step-by-step guide for future studies, so that they can be more comparable with each other when using measurement methods of earnings management.
DOI: 10.6084/m9.figshare.19923362.v1
title: Standard Jones and Modified Jones: An Earnings Management Tutorial

description: ABSTRACT Context: measurement of earnings management usually requires multi-step models for computation. After examining the literature through bibliometrics studies, literature review, and research databases, we found that the Standard Jones model and its subsequent modifications are those that have more prominent use. Much of this research is potentially interesting for business theories related to earnings quality and accounting manipulation; however, it is difficult to be understood by junior researchers and practitioners, because they are not clearly described in the literature or the steps may be easy to confuse. Objective: in this tutorial, we present several key concepts about earnings management and explain, step by step, how to measure it. Method: our tutorial considers measurement using the following models: Standard Jones, Modified Jones, Modified Jones with return on assets (ROA), and Modified Jones using Cash Flows and Accruals Reversals. Conclusions: our main contribution with this tutorial is to provide a step-by-step guide for future studies, so that they can be more comparable with each other when using measurement methods of earnings management.
DOI: 10.6084/m9.figshare.19923363
title: Antecedents of Commitment to Budgetary Goals

description: ABSTRACT Objective: this study analyzes the interactions between budgetary participation, motivation at work (intrinsic and extrinsic), and commitment to budgetary goals. Methods: a survey was carried out with 131 intermediate level managers from different organizational areas of companies classified among the best and biggest companies in Brazil. Results: the results of modeling structural equations indicate that intrinsic and extrinsic motivations have different roles in their interactions with budgetary participation and commitment to goals. And their involvement in the budgetary process reveals behavioral and motivational effects. Conclusions: it is concluded that participation in the budgetary process can positively reflect on managerial performance, insofar as it is able to trigger intrinsic motivational effect and favor behaviors aimed at the commitment to budgetary goals.