cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4807273.v1
title: Late chronotypes are associated with neoadjuvant chemotherapy-induced nausea and vomiting in women with breast cancer

description: Neoadjuvant chemotherapy, that is, the administration of chemotherapy before surgery, has been commonly used for locally advanced breast cancer to improve the surgical outcomes and increase the opportunity for breast-conserving therapy. Women with breast cancer often receive an anthracycline-based regimen as the neoadjuvant chemotherapy, which is associated with a high risk of emesis. Despite the development of novel antiemetics, chemotherapy-induced nausea and vomiting (CINV) has been commonly reported as a major adverse effect, affecting the quality of life of the patients. However, the factors predicting CINV in women with breast cancer undergoing neoadjuvant chemotherapy remain unclear. In this single-institution, prospective, observational study conducted at an outpatient cancer centre in the Republic of Korea from November 2013 to March 2016, we analysed women with breast cancer who planned to be treated with neoadjuvant chemotherapy before surgery. Candidate factors associated with CINV were assessed before neoadjuvant chemotherapy using the Munich Chronotype Questionnaire, Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale. CINV was assessed after chemotherapy by using the Multinational Association of Supportive Care in Cancer Antiemesis Tool. Of a total of 143 participants, 7 patients were lost to follow-up and 2 patients were excluded due to changes in their treatment plan; thus, 134 patients were finally included in the analyses. Overall, 48.5% of the participants experienced CINV, with delayed CINV prevalence (42.5%) being more common than acute (39.6%). In the univariate analyses, overall CINV was significantly associated with late chronotypes (odds ratio [OR], 3.49; 95% confidence interval [CI], 1.37–8.87; <i>p</i> = 0.009), a history of nausea/vomiting (OR, 2.19; 95% CI, 1.10–4.37; <i>p</i> = 0.026) and anxiety (OR, 2.25; 95% CI, 1.05–4.81; <i>p</i> = 0.036). In the multivariate analyses, late chronotypes (OR, 3.53; 95% CI, 1.27–9.79; <i>p</i> = 0.015) and a history of nausea/vomiting (OR, 2.83; 95% CI, 1.31–6.13; <i>p</i> = 0.008) remained significantly associated with CINV. In conclusion, in women with breast cancer undergoing neoadjuvant chemotherapy before surgery, late chronotypes were found to have an increased risk of CINV; these data suggest that clinicians need to assess and consider the chronotype in the management of CINV.
DOI: 10.6084/m9.figshare.4807237
title: Carboniferous porphyry Cu–Au deposits in the Almalyk orefield, Uzbekistan: the Sarycheku and Kalmakyr examples

description: The Almalyk porphyry cluster in the western part of the Central Asian Orogenic Belt is the second largest porphyry region in Asia and hence has attracted considerable attention of the geologists. In this contribution, we report the zircon U–Pb ages, major and trace element geochemistry as well as Sr–Nd isotopic data for the ore-related porphyries of the Sarycheku and Kalmakyr deposits. The zircon U–Pb ages (Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS)) of ore-bearing quartz monzonite and granodiorite porphyries from the Kalmakyr deposit are 326.1 ± 3.4 and 315.2 ± 2.8 Ma, and those for the ore-bearing granodiorite porphyries and monzonite dike from the Sarycheku deposit are 337.8 ± 3.1 and 313.2 ± 2.5 Ma, respectively. Together with the previous ages, they confine multi-phase intrusions from 337 to 306 Ma for the Almalyk ore cluster. Geochemically, all samples belong to shoshonitic series and are enriched in large-ion lithophile elements relative to high field strength elements with very low Nb/U weight ratios (0.83–2.56). They show initial (<sup>87</sup>Sr/<sup>86</sup>Sr)<sub>i</sub> ratios of 0.7059–0.7068 for Kalmakyr and 0.7067–0.7072 for Sarycheku and low ε<sub>Nd</sub>(t) values of −1.0 to −0.1 for Kalmakyr and −2.3 to 0.2 for Sarycheku, suggesting that the magmas were dominantly derived from a metasomatized mantle wedge modified by slab-derived fluids with the contribution of the continental crust by assimilation-fractional-crystallization process. Compared to the typical porphyry Cu deposits, the ore-bearing porphyries in the Almalyk cluster are shoshonitic instead of the calc-alkaline. Moreover, although the magmatic events were genetically related to a continental arc environment, the ore-bearing porphyries at Sarycheku and Kalmakyr do not show geochemical signatures of typical adakites as reflected in some giant porphyry deposits in the Circum-Pacific Ocean, indicating that slab-melting may not have been involved in their petrogenesis.
DOI: 10.6084/m9.figshare.4807237.v1
title: Carboniferous porphyry Cu–Au deposits in the Almalyk orefield, Uzbekistan: the Sarycheku and Kalmakyr examples

description: The Almalyk porphyry cluster in the western part of the Central Asian Orogenic Belt is the second largest porphyry region in Asia and hence has attracted considerable attention of the geologists. In this contribution, we report the zircon U–Pb ages, major and trace element geochemistry as well as Sr–Nd isotopic data for the ore-related porphyries of the Sarycheku and Kalmakyr deposits. The zircon U–Pb ages (Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS)) of ore-bearing quartz monzonite and granodiorite porphyries from the Kalmakyr deposit are 326.1 ± 3.4 and 315.2 ± 2.8 Ma, and those for the ore-bearing granodiorite porphyries and monzonite dike from the Sarycheku deposit are 337.8 ± 3.1 and 313.2 ± 2.5 Ma, respectively. Together with the previous ages, they confine multi-phase intrusions from 337 to 306 Ma for the Almalyk ore cluster. Geochemically, all samples belong to shoshonitic series and are enriched in large-ion lithophile elements relative to high field strength elements with very low Nb/U weight ratios (0.83–2.56). They show initial (<sup>87</sup>Sr/<sup>86</sup>Sr)<sub>i</sub> ratios of 0.7059–0.7068 for Kalmakyr and 0.7067–0.7072 for Sarycheku and low ε<sub>Nd</sub>(t) values of −1.0 to −0.1 for Kalmakyr and −2.3 to 0.2 for Sarycheku, suggesting that the magmas were dominantly derived from a metasomatized mantle wedge modified by slab-derived fluids with the contribution of the continental crust by assimilation-fractional-crystallization process. Compared to the typical porphyry Cu deposits, the ore-bearing porphyries in the Almalyk cluster are shoshonitic instead of the calc-alkaline. Moreover, although the magmatic events were genetically related to a continental arc environment, the ore-bearing porphyries at Sarycheku and Kalmakyr do not show geochemical signatures of typical adakites as reflected in some giant porphyry deposits in the Circum-Pacific Ocean, indicating that slab-melting may not have been involved in their petrogenesis.
DOI: 10.6084/m9.figshare.7075307
title: Interview - Tim Burns

description: This dataset 'Interview - Tim Burns’ is a component of a Doctor Of Philosophy conducted by candidate Alexander Hayes (3919493) titled 'The Socioethical Implications Of Body Worn Computers: An Ethnographic Study'. <br>The full thesis can be accessed at https://ro.uow.edu.au/theses1/853<br>This research was conducted in the Faculty of Engineering and Information Systems, School of Computing and Information Technology (SCIT), University of Wollongong with research strength Innovation in Business & Social Research under Principal Supervisor Professor Katina Michael (University of Wollongong) and Associate Supervisor Dr Teemu Leinonen (Aalto University Finland). This thesis explores the socioethical implications of body worn computers (BWC) using an ethnographic approach. Furthermore, a subset, body worn cameras (BWCs), combines data with value added constancy through Location Based Services (LBS) over wireless network connections. The aim of this investigation was to engage global leaders from transdisciplinary stakeholder groups in semi-structured interviews, conversations and events, situating a review of the social impact and ethical implications of BWCs. A critical discourse analysis using a Foucauldian approach reveals power relations, which are then infused through narrative with unique intercultural perspectives, differentiating ‘location’ from ‘place’. The author of this study has subsequently identified through Grounded Theory that BWCs are causal agency for disconnect from proper culture which can be addressed through the application of Ngikalikarra, a unique framework for empathetic understanding of place and community engagement.
DOI: 10.6084/m9.figshare.4807144
title: JGI data on bacteria

description: This dataset is a version of the JGI browser data on prokaryotic ecology and complete genome annotation.<br>- taxontable22946 contains all data sequenced at JGI- taxontable21706 contains all finished bacterial genomes- taxontable24580 contains all finished archaean genomes
DOI: 10.6084/m9.figshare.7075307.v1
title: Interview - Tim Burns

description: This dataset 'Interview - Tim Burns’ is a component of a Doctor Of Philosophy conducted by candidate Alexander Hayes (3919493) titled 'The Socioethical Implications Of Body Worn Computers: An Ethnographic Study'. <br>The full thesis can be accessed at https://ro.uow.edu.au/theses1/853<br>This research was conducted in the Faculty of Engineering and Information Systems, School of Computing and Information Technology (SCIT), University of Wollongong with research strength Innovation in Business & Social Research under Principal Supervisor Professor Katina Michael (University of Wollongong) and Associate Supervisor Dr Teemu Leinonen (Aalto University Finland). This thesis explores the socioethical implications of body worn computers (BWC) using an ethnographic approach. Furthermore, a subset, body worn cameras (BWCs), combines data with value added constancy through Location Based Services (LBS) over wireless network connections. The aim of this investigation was to engage global leaders from transdisciplinary stakeholder groups in semi-structured interviews, conversations and events, situating a review of the social impact and ethical implications of BWCs. A critical discourse analysis using a Foucauldian approach reveals power relations, which are then infused through narrative with unique intercultural perspectives, differentiating ‘location’ from ‘place’. The author of this study has subsequently identified through Grounded Theory that BWCs are causal agency for disconnect from proper culture which can be addressed through the application of Ngikalikarra, a unique framework for empathetic understanding of place and community engagement.
DOI: 10.6084/m9.figshare.4807144.v1
title: JGI data on bacteria

description: This dataset is a version of the JGI browser data on prokaryotic ecology and complete genome annotation.<br>- taxontable22946 contains all data sequenced at JGI- taxontable21706 contains all finished bacterial genomes- taxontable24580 contains all finished archaean genomes
DOI: 10.6084/m9.figshare.4807066
title: An equation of state based upon a ratio of polynomials (rational) form for the residual Helmholtz energy: application to nitrogen, argon and methane<sup>1</sup>

description: This work presents an equation of state that contains the residual Helmholtz free energy as a ratio of polynomials in density with temperature-dependent coefficients and demonstrates that it is a viable alternative for describing thermodynamic properties accurately. The specific form of the equation in this work has six density terms in the numerator, three density terms in the denominator, and five temperature parameters for each temperature-dependent coefficient. Nitrogen, argon, and methane serve as prototype fluids to demonstrate the capability of the form to describe <i>p</i>–ρ–<i>T</i> behaviour, vapour pressures, speeds of sound, and isochoric heat capacities up to 1000 MPa. Characteristic curves for several properties of nitrogen generated using the equation exhibit proper behaviour at high temperatures and pressures. Because the equation contains no exponential terms or non-integer exponents, the computational time associated with the new equation is more than a factor of 10 less than that required for similar equations with comparable accuracy.
DOI: 10.6084/m9.figshare.4807054
title: Socioeconomic Impacts of Climatic Change on Paddy Cultivation: An Empirical Investigation in Malaysia

description: AbstractThe changing natures of climatic factors have different impacts on agriculture based on areas,periods and crops. Farmers are the most vulnerable group who are affected both directly andindirectly through climatic changes. In the study area in Malaysia, climatic changes have adverseimpacts on farmers. Due to climatic change productivity and profitability of paddy cultivationhave declined in the Integrated Agricultural Development Area, North-West Selangar. Farmersperceive that paddy cultivation is no longer profitable due to low productivity as a result ofclimatic changes. They now prefer full-time to part-time engagement in paddy cultivation. Heavygovernment subsidy and encouragement are not enough; it requires increase in productivity andprofitability of paddy cultivation for making its viable and sustainable sector. All efforts ofmitigation and adaptation must be pursued to counter the adverse impacts of climatic changesand increase the productivity of paddy cultivation in the area. It is observed that there is a highdegree of income inequality among the paddy farmers in the study area.
DOI: 10.6084/m9.figshare.4807066.v1
title: An equation of state based upon a ratio of polynomials (rational) form for the residual Helmholtz energy: application to nitrogen, argon and methane<sup>1</sup>

description: This work presents an equation of state that contains the residual Helmholtz free energy as a ratio of polynomials in density with temperature-dependent coefficients and demonstrates that it is a viable alternative for describing thermodynamic properties accurately. The specific form of the equation in this work has six density terms in the numerator, three density terms in the denominator, and five temperature parameters for each temperature-dependent coefficient. Nitrogen, argon, and methane serve as prototype fluids to demonstrate the capability of the form to describe <i>p</i>–ρ–<i>T</i> behaviour, vapour pressures, speeds of sound, and isochoric heat capacities up to 1000 MPa. Characteristic curves for several properties of nitrogen generated using the equation exhibit proper behaviour at high temperatures and pressures. Because the equation contains no exponential terms or non-integer exponents, the computational time associated with the new equation is more than a factor of 10 less than that required for similar equations with comparable accuracy.
DOI: 10.6084/m9.figshare.4807006
title: Regional Southwest UK Sediment Size and Sorting

description: Surface sediment size at 53 separate beach locations distributed around the southwest of the UK
DOI: 10.6084/m9.figshare.4806991
title: On Recursive Bayesian Predictive Distributions

description: A Bayesian framework is attractive in the context of prediction, but a fast recursive update of the predictive distribution has apparently been out of reach, in part because Monte Carlo methods are generally used to compute the predictive. This article shows that online Bayesian prediction is possible by characterizing the Bayesian predictive update in terms of a bivariate copula, making it unnecessary to pass through the posterior to update the predictive. In standard models, the Bayesian predictive update corresponds to familiar choices of copula but, in nonparametric problems, the appropriate copula may not have a closed-form expression. In such cases, our new perspective suggests a fast recursive approximation to the predictive density, in the spirit of Newton’s predictive recursion algorithm, but without requiring evaluation of normalizing constants. Consistency of the new algorithm is shown, and numerical examples demonstrate its quality performance in finite-samples compared to fully Bayesian and kernel methods. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.4807006.v1
title: Regional Southwest UK Sediment Size and Sorting

description: Surface sediment size at 53 separate beach locations distributed around the southwest of the UK
DOI: 10.6084/m9.figshare.4806985
title: Hypoxia and Hypoglycemia synergistically regulate mRNA stability

description: Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, much less is known about the posttranscriptional response to oxygen and glucose deprivation. The goal of this project was to investigate one such posttranscriptional response, the regulation of mRNA stability. To that end, we have identified several novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61. This increase in mRNA half-life requires the synergistic effects of both low oxygen (1%) as well as low glucose (≤ 1 g/L) conditions. Oxygen or glucose deprivation alone fails to initiate the response, as exposure to either high glucose (4 g/L) or normoxic conditions inhibits the response. Furthermore, in response to hypoxia/hypoglycemia, the identified mRNAs are released from the RNA binding protein KHSRP which likely contributes to their stabilization.
DOI: 10.6084/m9.figshare.4806991.v2
title: On Recursive Bayesian Predictive Distributions

description: A Bayesian framework is attractive in the context of prediction, but a fast recursive update of the predictive distribution has apparently been out of reach, in part because Monte Carlo methods are generally used to compute the predictive. This article shows that online Bayesian prediction is possible by characterizing the Bayesian predictive update in terms of a bivariate copula, making it unnecessary to pass through the posterior to update the predictive. In standard models, the Bayesian predictive update corresponds to familiar choices of copula but, in nonparametric problems, the appropriate copula may not have a closed-form expression. In such cases, our new perspective suggests a fast recursive approximation to the predictive density, in the spirit of Newton’s predictive recursion algorithm, but without requiring evaluation of normalizing constants. Consistency of the new algorithm is shown, and numerical examples demonstrate its quality performance in finite-samples compared to fully Bayesian and kernel methods. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.4806970
title: Estrogen signaling, through estrogen receptor β, regulates DNA methylation and its machinery in male germ line in adult rats

description: Estrogen, through its receptors, regulates various aspects of spermatogenesis and male fertility. To understand the roles of estrogen receptors (ERα and ERβ) in male fertility, we have developed <i>in vivo</i> selective ER agonist administration models. Treatment of adult male rats with ERα or ERβ agonist for 60 d decreases fertility and litter size mainly due to increased pre- and post-implantation embryo loss. Since epigenetic mechanisms like DNA methylation play a crucial role in male fertility, we investigated the effects of the ER agonists on DNA methylation in spermatozoa. Treatment with ERβ agonist causes a significant decrease in DNA methylation both at the global level and at the <i>H19</i> differentially methylated region (DMR). This could be due to decrease in DNA methyltransferases in the testis upon ERβ agonist treatment. The hypomethylation observed at the <i>H19</i> DMR corroborates with aberrant expression of <i>Igf2</i> and <i>H19</i> imprinted genes in the resorbed embryos sired by ERβ agonist-treated males. Thus, our study demonstrates that ERβ regulates DNA methylation and methylating enzymes during adult rat spermatogenesis. Activation of estrogen signaling through ERβ could therefore cause DNA methylation defects leading to impaired male fertility. These results define a role for estrogen in epigenetic regulation of male germ line, suggesting that epigenetic insults by exposure to environmental estrogens could potentially affect male fertility.
DOI: 10.6084/m9.figshare.4806985.v2
title: Hypoxia and Hypoglycemia synergistically regulate mRNA stability

description: Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, much less is known about the posttranscriptional response to oxygen and glucose deprivation. The goal of this project was to investigate one such posttranscriptional response, the regulation of mRNA stability. To that end, we have identified several novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61. This increase in mRNA half-life requires the synergistic effects of both low oxygen (1%) as well as low glucose (≤ 1 g/L) conditions. Oxygen or glucose deprivation alone fails to initiate the response, as exposure to either high glucose (4 g/L) or normoxic conditions inhibits the response. Furthermore, in response to hypoxia/hypoglycemia, the identified mRNAs are released from the RNA binding protein KHSRP which likely contributes to their stabilization.
DOI: 10.6084/m9.figshare.4806991.v1
title: On recursive Bayesian predictive distributions

description: A Bayesian framework is attractive in the context of prediction, but a fast recursive update of the predictive distribution has apparently been out of reach, in part because Monte Carlo methods are generally used to compute the predictive. This paper shows that online Bayesian prediction is possible by characterizing the Bayesian predictive update in terms of a bivariate copula, making it unnecessary to pass through the posterior to update the predictive. In standard models, the Bayesian predictive update corresponds to familiar choices of copula but, in nonparametric problems, the appropriate copula may not have a closed-form expression. In such cases, our new perspective suggests a fast recursive approximation to the predictive density, in the spirit of Newton's predictive recursion algorithm, but without requiring evaluation of normalizing constants. Consistency of the new algorithm is shown, and numerical examples demonstrate its quality performance in finite-samples compared to fully Bayesian and kernel methods.