DOI: 10.5061/dryad.s181n
title: Data from: A prezygotic transmission distorter acting equally in female and male zebra finches Taeniopygia guttata

description: The two parental alleles at a specific locus are usually inherited with
 equal probability to the offspring. However, at least three processes can
 lead to an apparent departure from fair segregation: early viability
 selection, biased gene conversion and various kinds of segregation
 distortion. Here, we conduct a genome-wide scan for transmission
 distortion in a captive population of zebra finches (Taeniopygia guttata)
 using 1302 single-nucleotide polymorphisms (SNPs) followed by confirmatory
 analyses on independent samples from the same population. In the initial
 genome-wide scan, we found significant distortion at three linked loci on
 chromosome Tgu2 and we were able to replicate this finding in each of two
 follow-up data sets [overall transmission ratio = 0.567 (95% CI =
 0.536–0.600), based on 1101 informative meioses]. Although the driving
 allele was preferentially transmitted by both heterozygous females [ratio
 = 0.560 (95% CI = 0.519–0.603)] and heterozygous males [ratio = 0.575 (95%
 CI = 0.531–0.623)], we could rule out postzygotic viability selection and
 biased gene conversion as possible mechanisms. Early postzygotic viability
 selection is unlikely, because it would result in eggs with no visible
 embryo and hence no opportunity for genotyping, and we confirmed that both
 females and males heterozygous for the driving allele did not produce a
 larger proportion of such eggs than homozygous birds. Biased gene
 conversion is expected to be rather localized, while we could trace
 transmission distortion in haplotypes of several megabases in a
 recombination desert. Thus, we here report the rare case of a
 prezygotically active transmission distorter operating equally effectively
 in female and male meioses.
description: data_Tgu2_genotypes“data_Tgu2_genotypes.txt” contains genotypes and additional information on all individuals used in the current study for the driving locus on chromosome Tgu2 (SNP rs82439854).data_Tgu5_genotypes“data_Tgu5_genotypes.txt” contains genotypes and additional information on all individuals used in the current study for the driving locus on chromosome Tgu5 (SNP rs82439270).results_TransmissionDistortion_CombinedSexes“results_TransmissionDistortion_CombinedSexes.txt” contains results of binomial tests for transmission distortion for every SNP for the combined-sexes scan.results_TransmissionDistortion_Females“results_TransmissionDistortion_Females.txt” contains results of binomial tests for transmission distortion for every SNP for the female-specific scan.results_TransmissionDistortion_Males“results_TransmissionDistortion_Males.txt” contains results of binomial tests for transmission distortion for every SNP for the male-specific scan.results_TransmissionDistortion_HetFemalesOnly“results_TransmissionDistortion_HetFemalesOnly.txt” contains results of binomial tests for transmission distortion for every SNP for the female-specific scan excluding those pairs in which both female and male are heterozygous.results_TransmissionDistortion_HetMalesOnly“results_TransmissionDistortion_HetMalesOnly.txt” contains results of binomial tests for transmission distortion for every SNP for the male-specific scan excluding those pairs in which both female and male are heterozygous.data_simulation_GenomeWideTransmissionDistortion“data_simulation_GenomeWideTransmissionDistortion” is the input file for the genome-wide test for transmission distortion.simulation_GenomeWideTransmissionDistortion“simulation_GenomeWideTransmissionDistortion.r” contains the script for the simulation used to test for genome-wide transmission distortion.