cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9927920
title: CONVERSION OF SPENT FAT OIL INTO LIQUID AND GASEOUS FUELS THROUGH CLINKER CATALYZED PYROLYSIS

description: Abstract Repeated heating of fat oil may result in the formation of highly toxic aldehyde compounds. The oils having such compounds are considered as health hazards and therefore their repeated use is banned in many countries. Since huge quantities of the used oil need urgent disposal, this work is focused on the disposal of used oil for the resource recovery. The waste fat oil was converted into useful fuel through catalytic and non-catalytic pyrolysis. The catalyst was used to lower the oxygen content and to increase the amount of the hydrocarbons in the oil product. The pyrolysis reaction was catalyzed by three catalysts of the clinker type, namely ordinary Portland cement, white cement and burnt clay/clinker powder. The pyrolysis reactions were performed using a custom-made furnace and stainless steel pyrolyzer. Optimum temperature, time and catalyst quantity were identified for high liquid and gaseous fractions and low solid residue. The oil obtained during each reaction was characterized for chemical composition by using GC-MS technique. The oil product of simple pyrolysis, cement catalyzed, white cement catalyzed and clinker catalyzed pyrolysis had the hydrocarbon contents of 3%, 19%, 51% and 93%, respectively.
DOI: 10.6084/m9.figshare.9927926.v1
title: Technical efficiency and technological heterogeneity in agriculture in the semi-arid and non-semi-arid regions of northeastern Brazil

description: Abstract This study aims to analyze the technological differences in agricultural production between the municipalities in the semiarid and non-semiarid Northeast Brazil. It uses the technological meta-frontier model proposed by Battese, Rao e O’Donnell (2004), and O’Donnell, Rao e Battese (2008), for responding to what extent these regional differences influence the efficiency of production. It was observed that the hypothesis that the municipalities belonging to the semiarid and non-semiarid face with different production opportunities. The results indicated, that comparing both regions, the non-semiarid region has the highest average technical efficiency with reference to meta-frontier.
DOI: 10.6084/m9.figshare.9927917
title: FORMULATION AND CHARACTERIZATION OF ULTRASOUND-ASSISTED NANOEMULSIONS CONTAINING PALM OIL (Elaeis guineensis Jacq) IN WATER

description: Abstract This study aimed to optimize ultrasound-assisted palm oil-in-water nanoemulsions. The influence of hydrophilic-lipophilic balance (HLB), oil and surfactants concentrations, ultrasound intensity and processing time were investigated by means of two experimental designs. Desirability profiles were applied to detect the optimal conditions for preparing the nanoemulsion. Stable nanoemulsions with small droplet size and polydispersity index (PDI) were obtained at an HLB of 6.5, oil and surfactant concentrations of 2.8 wt%, ultrasound intensity of 200 W.cm-2 and processing time of 15 minutes. The nanoemulsion presented stability for 30 days at three different temperatures (4°C, 25°C and 40°C), which makes it suitable for application in the food and cosmetic industries. Ultrasound was shown to be a promising technology to produce nanoemulsions containing palm oil.
DOI: 10.6084/m9.figshare.9927920.v1
title: CONVERSION OF SPENT FAT OIL INTO LIQUID AND GASEOUS FUELS THROUGH CLINKER CATALYZED PYROLYSIS

description: Abstract Repeated heating of fat oil may result in the formation of highly toxic aldehyde compounds. The oils having such compounds are considered as health hazards and therefore their repeated use is banned in many countries. Since huge quantities of the used oil need urgent disposal, this work is focused on the disposal of used oil for the resource recovery. The waste fat oil was converted into useful fuel through catalytic and non-catalytic pyrolysis. The catalyst was used to lower the oxygen content and to increase the amount of the hydrocarbons in the oil product. The pyrolysis reaction was catalyzed by three catalysts of the clinker type, namely ordinary Portland cement, white cement and burnt clay/clinker powder. The pyrolysis reactions were performed using a custom-made furnace and stainless steel pyrolyzer. Optimum temperature, time and catalyst quantity were identified for high liquid and gaseous fractions and low solid residue. The oil obtained during each reaction was characterized for chemical composition by using GC-MS technique. The oil product of simple pyrolysis, cement catalyzed, white cement catalyzed and clinker catalyzed pyrolysis had the hydrocarbon contents of 3%, 19%, 51% and 93%, respectively.
DOI: 10.6084/m9.figshare.9927917.v1
title: FORMULATION AND CHARACTERIZATION OF ULTRASOUND-ASSISTED NANOEMULSIONS CONTAINING PALM OIL (Elaeis guineensis Jacq) IN WATER

description: Abstract This study aimed to optimize ultrasound-assisted palm oil-in-water nanoemulsions. The influence of hydrophilic-lipophilic balance (HLB), oil and surfactants concentrations, ultrasound intensity and processing time were investigated by means of two experimental designs. Desirability profiles were applied to detect the optimal conditions for preparing the nanoemulsion. Stable nanoemulsions with small droplet size and polydispersity index (PDI) were obtained at an HLB of 6.5, oil and surfactant concentrations of 2.8 wt%, ultrasound intensity of 200 W.cm-2 and processing time of 15 minutes. The nanoemulsion presented stability for 30 days at three different temperatures (4°C, 25°C and 40°C), which makes it suitable for application in the food and cosmetic industries. Ultrasound was shown to be a promising technology to produce nanoemulsions containing palm oil.
DOI: 10.6084/m9.figshare.9927905
title: Use of conjugated linoleic acid (trans 10, cis 12) to cultivate bovine embryos: effect on cryoresistance and lipid content

description: ABSTRACT This study evaluated the effect of the addition of conjugated linoleic acid (CLA) to in vitro culture on viability, lipid content, and cryoresistance of bovine embryos at different in vitro culture times. Cumulus oocyte complexes (N = 974) were maturated in vitro for 22 h. In vitro fecundation ensued for 18 h. Viable zygotes were cultivated in vitro in medium supplemented with CLA (100 mM) in the first 72 h (CLA-F), last 72 h (CLA-L), or throughout the culture period (CLA-T). Control embryos (control) were cultivated with no CLA. Embryos were cryopreserved by vitrification for subsequent analysis after devitrification. Effect of CLA on cryoresistance was assessed by cultivating embryos in synthetic oviductal fluid containing 5% fetal bovine serum. Lipid content was quantified using Nile Red staining. No significant difference was observed in cleavage rate, blastocyst:total oocyte ratio, and blastocyst:cleaved oocyte ratio. Culture in CLA-L reduced survival rate 24 h after devitrification compared with CLA-F and CLA-T, although with no statistically significant difference compared with control group. However, CLA-T improved embryo hatching rate and affected lipid content of embryos. Cultures CLA-F and CLA-L increased lipid content compared with control. Yet, lipid content values decreased in embryos treated with CLA-T, but they did not differ significantly from the values observed for oocytes at the germinal vesicle stage. Treatment of bovine embryos with CLA during in vitro cultivation did not affect the production of blastocysts, reducing lipid content and improving cryoresistance. However, the effects of CLA on cryoresistance and lipid content is significant only when embryos are exposed to the compound throughout the cultivation period.
DOI: 10.6084/m9.figshare.9927899
title: Chronic kidney disease is a main confounding factor for 25-vitamin D measurement

description: Abstract Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR &lt; 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.
DOI: 10.6084/m9.figshare.9927890
title: CONTROLLED RELEASE OF THEOPHYLLINE-CHITOSAN COMPOSITE PARTICLES PREPARED USING SUPERCRITICAL ASSISTED ATOMIZATION

description: Abstract This study investigated the formation of composite particles of chitosan (CS) and theophylline (TPH) via supercritical assisted atomization (SAA) using aqueous ethanol (50%, v/v) as the solvent and supercritical CO2 as the spraying medium. According to XRD, DSC, and FTIR analyses, the crystal form of the SAA-treated TPH from the as-received TPH was unchanged. The effect of different mass ratios of CS to TPH on the in vitro release of TPH showed that the dissolution of the highly water-soluble TPH was retarded when included in the composite particles and could be controlled by the mass ratio of the component in the SAA process. The in vitro dissolution data showed a good fit with the Peppas-Sahlin model, which was used to conclude that the drug release from the composite particles resulted from a combination of drug diffusion and relaxation of the polymer. As the mass ratio of CS to TPH increased, the mechanism relating to polymer relaxation became crucial in the TPH-CS composite particles.
DOI: 10.6084/m9.figshare.9927893
title: Effect of Squeeze Casting on Microhardness and Microstructure of Al-3Cu-xSi Alloy

description: Aluminum alloys of the ANSI series 319 present Si and Cu as the main alloying elements and the mechanical strength of these alloys can be improved by the precipitation of the metastable Al2Cu phase. Squeeze Casting is a casting process in which the cast metal is deposited in a metal mold and solidified under certain pressure exerted by a punch. This process provides changes in the microstructure which lead to changes in the mechanical properties of the material such as the increase in the microhardness of the processed alloy. alloys Al-5,5% Si-3% Cu, Al-7,5% Si-3% and Al-9% Si-3% Cu alloys were solidified by the squeeze casting process to analyze the microstructural and microhardness variations. Pressures of 0 MPa, 50 MPa, 100 MPa and 150 Mpa were used. In general, with increasing pressure and composition, the λ2 values decrease from the metal/mold interface, especially at pressures of 150 MPa and Composition of 9%Si, on the other hand the increase of these variables leads to the formation of more phases Al2Cu metastable that have a decrease in the Microhardness of the material, in addition to the formation of other phases due to the proximity to the eutetic.
DOI: 10.6084/m9.figshare.9927905.v1
title: Use of conjugated linoleic acid (trans 10, cis 12) to cultivate bovine embryos: effect on cryoresistance and lipid content

description: ABSTRACT This study evaluated the effect of the addition of conjugated linoleic acid (CLA) to in vitro culture on viability, lipid content, and cryoresistance of bovine embryos at different in vitro culture times. Cumulus oocyte complexes (N = 974) were maturated in vitro for 22 h. In vitro fecundation ensued for 18 h. Viable zygotes were cultivated in vitro in medium supplemented with CLA (100 mM) in the first 72 h (CLA-F), last 72 h (CLA-L), or throughout the culture period (CLA-T). Control embryos (control) were cultivated with no CLA. Embryos were cryopreserved by vitrification for subsequent analysis after devitrification. Effect of CLA on cryoresistance was assessed by cultivating embryos in synthetic oviductal fluid containing 5% fetal bovine serum. Lipid content was quantified using Nile Red staining. No significant difference was observed in cleavage rate, blastocyst:total oocyte ratio, and blastocyst:cleaved oocyte ratio. Culture in CLA-L reduced survival rate 24 h after devitrification compared with CLA-F and CLA-T, although with no statistically significant difference compared with control group. However, CLA-T improved embryo hatching rate and affected lipid content of embryos. Cultures CLA-F and CLA-L increased lipid content compared with control. Yet, lipid content values decreased in embryos treated with CLA-T, but they did not differ significantly from the values observed for oocytes at the germinal vesicle stage. Treatment of bovine embryos with CLA during in vitro cultivation did not affect the production of blastocysts, reducing lipid content and improving cryoresistance. However, the effects of CLA on cryoresistance and lipid content is significant only when embryos are exposed to the compound throughout the cultivation period.
DOI: 10.6084/m9.figshare.12756020.v2
title: The association of smoking status with SARS-CoV-2 infection, hospitalisation and mortality from COVID-19: A living rapid evidence review and Bayesian meta-analyses (version 6) - Data

description: Data extraction from identified articles reporting on SARS-CoV-2 infection, COVID-19 hospitalisation, severity or mortality.
DOI: 10.6084/m9.figshare.9927893.v1
title: Effect of Squeeze Casting on Microhardness and Microstructure of Al-3Cu-xSi Alloy

description: Aluminum alloys of the ANSI series 319 present Si and Cu as the main alloying elements and the mechanical strength of these alloys can be improved by the precipitation of the metastable Al2Cu phase. Squeeze Casting is a casting process in which the cast metal is deposited in a metal mold and solidified under certain pressure exerted by a punch. This process provides changes in the microstructure which lead to changes in the mechanical properties of the material such as the increase in the microhardness of the processed alloy. alloys Al-5,5% Si-3% Cu, Al-7,5% Si-3% and Al-9% Si-3% Cu alloys were solidified by the squeeze casting process to analyze the microstructural and microhardness variations. Pressures of 0 MPa, 50 MPa, 100 MPa and 150 Mpa were used. In general, with increasing pressure and composition, the λ2 values decrease from the metal/mold interface, especially at pressures of 150 MPa and Composition of 9%Si, on the other hand the increase of these variables leads to the formation of more phases Al2Cu metastable that have a decrease in the Microhardness of the material, in addition to the formation of other phases due to the proximity to the eutetic.
DOI: 10.6084/m9.figshare.9927890.v1
title: CONTROLLED RELEASE OF THEOPHYLLINE-CHITOSAN COMPOSITE PARTICLES PREPARED USING SUPERCRITICAL ASSISTED ATOMIZATION

description: Abstract This study investigated the formation of composite particles of chitosan (CS) and theophylline (TPH) via supercritical assisted atomization (SAA) using aqueous ethanol (50%, v/v) as the solvent and supercritical CO2 as the spraying medium. According to XRD, DSC, and FTIR analyses, the crystal form of the SAA-treated TPH from the as-received TPH was unchanged. The effect of different mass ratios of CS to TPH on the in vitro release of TPH showed that the dissolution of the highly water-soluble TPH was retarded when included in the composite particles and could be controlled by the mass ratio of the component in the SAA process. The in vitro dissolution data showed a good fit with the Peppas-Sahlin model, which was used to conclude that the drug release from the composite particles resulted from a combination of drug diffusion and relaxation of the polymer. As the mass ratio of CS to TPH increased, the mechanism relating to polymer relaxation became crucial in the TPH-CS composite particles.
DOI: 10.6084/m9.figshare.9927899.v1
title: Chronic kidney disease is a main confounding factor for 25-vitamin D measurement

description: Abstract Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR &lt; 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.
DOI: 10.6084/m9.figshare.9927872
title: LIPIDS AS COMPETITIVE INHIBITORS OF SUBTILISIN CARLSBERG IN THE ENZYMATIC HYDROLYSIS OF PROTEINS IN RED TILAPIA (Oreochromis sp.) VISCERA: INSIGHTS FROM KINETIC MODELS AND A MOLECULAR DOCKING STUDY

description: Abstract Protein hydrolysis can improve food’s nutritional, techno-functional and biological properties, which can increase the possibilities of application in industry. The objective of this research article was to study the effect of lipids on the enzymatic kinetics of red tilapia viscera (RTV) hydrolysis with subtilisin Carlsberg. The RTV were hydrolyzed in an enzyme/substrate ratio of 0.153 (U/g), at 53° C, at a pH of 9.5, initial concentrations of lipids of 1, 19 and 50 g/L, and different initial substrate concentrations for each initial lipid concentration. To explain the lipid action mechanism, we evaluated a Michaelis-Menten model and another semi-physical model based on kinetic expressions and mass balances. Additionally, a molecular docking analysis was performed between subtilisin Carlsberg and the main fatty acid in RTV (palmitic acid). For both models, the results suggest a strong competitive inhibition by lipids, with an inhibition constant of 2.36 and 3.01 g/L for the first and second models, respectively. On the other hand, docking suggested that palmitic acid could form van der Waals interactions and hydrogen bonds with the residues of the active site of subtilisin Carlsberg and occupy part of the substrate binding site, thus acting as an effective competitive inhibitor.
DOI: 10.6084/m9.figshare.9927875
title: SYNTHESIS AND CHARACTERIZATION OF FRUCTOSYLTRANSFERASE FROM Aspergillus oryzae IPT-301 FOR HIGH FRUCTOOLIGOSACCHARIDES PRODUCTION

description: Abstract Fructooligosaccharides (FOS) are mainly produced by microbial fructosyltransferases (FTase, E.C.2.4.1.9), and Aspergillus oryzae IPT-301 has shown high fructosyl transferring and low hydrolytic activities, which leads to high FOS production yields, but the main operating parameters for its best performance have been scarcely studied. Thus, this work aimed to evaluate the cellular growth, production and characterization of mycelial and extracellular FTases by Aspergillus oryzae IPT-301. Experimental design showed that the extracellular FTase performance was optimized (high transfructosylation activity and low hydrolytic activity) for reaction pH 5.5 - 6.75 and temperature of 45-50 °C and was fitted by the Michaelis-Menten model, while the mycelial FTase showed better performance at pH below 6.5 and temperature above 46 °C and was better fitted by the Hill model. The results obtained showed that the fungus represents a promising source for FOS production on a laboratorial scale.
DOI: 10.6084/m9.figshare.9927878
title: Successful multiple-exchange peritoneal dialysis in a patient with severe hematological toxicity by methotrexate: case report and literature review

description: Abstract Methotrexate is an effective medication to control several diseases; however, it can be very toxic, being myelosuppression one of its main adverse effects, which increases in severity and frequency in patients with renal failure. We present the case of a 68-year-old man with chronic, end-stage renal disease associated with ANCA vasculitis, under treatment with peritoneal dialysis, who received the medication at a low dose, indicated by disease activity, which presented as a complication with severe pancytopenia with mucositis that improved with support measures and multiple-exchange peritoneal dialysis. We reviewed 20 cases published to date of pancytopenia associated with methotrexate in patients on dialysis and found high morbidity and mortality, which is why its use in this type of patient is not recommended. However, when this complication occurs, a therapeutic option could be the use of multiple-exchange peritoneal dialysis in addition to supportive therapy for drug-related toxicity, although it is recognized that studies are required to show the role of multiple-exchange peritoneal dialysis in the removal of this medication.
DOI: 10.6084/m9.figshare.9927878.v1
title: Successful multiple-exchange peritoneal dialysis in a patient with severe hematological toxicity by methotrexate: case report and literature review

description: Abstract Methotrexate is an effective medication to control several diseases; however, it can be very toxic, being myelosuppression one of its main adverse effects, which increases in severity and frequency in patients with renal failure. We present the case of a 68-year-old man with chronic, end-stage renal disease associated with ANCA vasculitis, under treatment with peritoneal dialysis, who received the medication at a low dose, indicated by disease activity, which presented as a complication with severe pancytopenia with mucositis that improved with support measures and multiple-exchange peritoneal dialysis. We reviewed 20 cases published to date of pancytopenia associated with methotrexate in patients on dialysis and found high morbidity and mortality, which is why its use in this type of patient is not recommended. However, when this complication occurs, a therapeutic option could be the use of multiple-exchange peritoneal dialysis in addition to supportive therapy for drug-related toxicity, although it is recognized that studies are required to show the role of multiple-exchange peritoneal dialysis in the removal of this medication.