cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23541291
title: Supplementary Material for: The Impact of Obesity on T and NK Cells after LVAD Implantation

description: <b><i>Introduction:</i></b> Infections are a major problem after left ventricular assist device (LVAD) implantation that affects morbidity, mortality, and the quality of life. Obesity often increases the risk for infection. In the cohort of LVAD patients, it is unknown if obesity affects the immunological parameters involved in viral defense. Therefore, this study investigated whether overweight or obesity affects immunological parameters such as CD8<sup>+</sup> T cells and natural killer (NK) cells. <b><i>Methods:</i></b> Immune cell subsets of CD8<sup>+</sup> T cells and NK cells were compared between normal-weight (BMI 18.5–24.9 kg/m<sup>2</sup>, <i>n</i> = 17), pre-obese (BMI 25.0–29.9 kg/m<sup>2</sup>, <i>n</i> = 24), and obese (BMI ≥30 kg/m<sup>2</sup>, <i>n</i> = 27) patients. Cell subsets and cytokine serum levels were quantified prior to LVAD implantation and at 3, 6, and 12 months after LVAD implantation. <b><i>Results:</i></b> At the end of the first postoperative year, obese patients (31.8% ± 2.1%) had a lower proportion of CD8<sup><b>+</b></sup> T cells than normal-weight patients (42.4% ± 4.1%; <i>p</i> = 0.04), and the percentage of CD8<sup><b>+</b></sup> T cells was negatively correlated with BMI (<i>p</i> = 0.03; <i>r</i> = −0.329). The proportion of circulating NK cells increased after LVAD implantation patients in normal-weight (<i>p</i> = 0.01) and obese patients (<i>p</i> &lt; 0.01). Patients with pre-obesity showed a delayed increase (<i>p</i> &lt; 0.01) 12 months after LVAD implantation. Further, obese patients showed an increase in the percentage of CD57<sup>+</sup> NK cells after 6 and 12 months (<i>p</i> = 0.01) of treatment, higher proportions of CD56<sup>bright</sup> NK cells (<i>p</i> = 0.01), and lower proportions of CD56<sup>dim/neg</sup> NK cells (<i>p</i> = 0.03) 3 months after LVAD implantation than normal-weight patients. The proportion of CD56<sup>bright</sup> NK cells positively correlated with BMI (<i>p</i> &lt; 0.01, <i>r</i> = 0.403) 1 year after LVAD implantation. <b><i>Conclusions:</i></b> This study documented that obesity affects CD8<sup>+</sup> T cells and subsets of NK cells in patients with LVAD in the first year after LVAD implantation. Lower proportions of CD8<sup>+</sup> T cells and CD56<sup>dim/neg</sup> NK cells and higher proportion of CD56<sup>bright</sup> NK cells were detected in obese but not in pre-obese and normal-weight LVAD patients during the first year after LVAD implantation. The induced immunological imbalance and phenotypic changes of T and NK cells may influence viral and bacterial immunoreactivity.
DOI: 10.6084/m9.figshare.22820726
title: Supplementary Material for: Soluble CD14 and osteoprotegerin associate with ankle-brachial index as a measure of arterial stiffness in patients with mild to moderate chronic kidney disease in a five-year prospective study.

description: Introduction Vascular lesions and arterial stiffness appear at early stages of chronic kidney disease (CKD) and follow an accelerated course with disease progression, contributing to high cardiovascular mortality. There are limited prospective data on mechanisms contributing to progression of arterial stiffness in mild to moderate CKD (stages 2-3). Methods We applied an affinity proteomics approach to identify candidates of circulating biomarkers with potential impact on vascular lesions in CKD and selected soluble cluster of differentiation 14 (sCD14), angiogenin (ANG) and osteoprotegerin (OPG) for further analysis. We studied their association with Ankle-brachial index (ABI) and carotid intima–media thickness (CIMT), as measures of arteriosclerosis and atherosclerosis respectively, in 48 patients with CKD stages 2-3, who were prospectively followed and intensively treated for five years, and 44 healthy controls. Results Concentrations of both sCD14 (p&lt;0.001), ANG (p&lt;0.001) and OPG (p&lt;0.05) were higher in patients with CKD 2-3 at baseline, and sCD14 (p&lt;0.001) and ANG (p&lt;0.001) remained elevated in CKD patients at follow-up. There were positive correlations between ABI and sCD14 levels (r=0.36, p=0.01) and between ABI and OPG (r=0.31, p=0.03) at five years. The changes in sCD14 during follow-up correlated to changes in ABI from baseline to five years (r=0.41, p=0.004). Conclusion Elevated levels of circulating sCD14 and OPG in patients with CKD 2-3 were significantly associated with ABI, a measure of arterial stiffness. An increase in sCD14 over time in CKD 2-3 patients was associated with a corresponding increase in ABI. Further studies are needed to examine if early intensive multifactorial medication to align with international treatment targets may influence cardiovascular outcomes.
DOI: 10.6084/m9.figshare.22820726.v1
title: Supplementary Material for: Soluble CD14 and osteoprotegerin associate with ankle-brachial index as a measure of arterial stiffness in patients with mild to moderate chronic kidney disease in a five-year prospective study.

description: Introduction Vascular lesions and arterial stiffness appear at early stages of chronic kidney disease (CKD) and follow an accelerated course with disease progression, contributing to high cardiovascular mortality. There are limited prospective data on mechanisms contributing to progression of arterial stiffness in mild to moderate CKD (stages 2-3). Methods We applied an affinity proteomics approach to identify candidates of circulating biomarkers with potential impact on vascular lesions in CKD and selected soluble cluster of differentiation 14 (sCD14), angiogenin (ANG) and osteoprotegerin (OPG) for further analysis. We studied their association with Ankle-brachial index (ABI) and carotid intima–media thickness (CIMT), as measures of arteriosclerosis and atherosclerosis respectively, in 48 patients with CKD stages 2-3, who were prospectively followed and intensively treated for five years, and 44 healthy controls. Results Concentrations of both sCD14 (p&lt;0.001), ANG (p&lt;0.001) and OPG (p&lt;0.05) were higher in patients with CKD 2-3 at baseline, and sCD14 (p&lt;0.001) and ANG (p&lt;0.001) remained elevated in CKD patients at follow-up. There were positive correlations between ABI and sCD14 levels (r=0.36, p=0.01) and between ABI and OPG (r=0.31, p=0.03) at five years. The changes in sCD14 during follow-up correlated to changes in ABI from baseline to five years (r=0.41, p=0.004). Conclusion Elevated levels of circulating sCD14 and OPG in patients with CKD 2-3 were significantly associated with ABI, a measure of arterial stiffness. An increase in sCD14 over time in CKD 2-3 patients was associated with a corresponding increase in ABI. Further studies are needed to examine if early intensive multifactorial medication to align with international treatment targets may influence cardiovascular outcomes.
DOI: 10.5517/ccdc.csd.cc2djg1g
title: CCDC 2220345: Experimental Crystal Structure Determination

description: Related Article: Charanjeet Sen, Richa Singhaal, Nargis Akhter Ashashi, Swaita Devi, Musheer Ahmad, Haq Nawaz Sheikh|2023|J.Mol.Struct.|1290|135970|doi:10.1016/j.molstruc.2023.135970
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2dpz9d
title: CCDC 2225654: Experimental Crystal Structure Determination

description: Related Article: Rumyana Yankova, Ivaylo Tankov|2023|J.Mol.Struct.|1290|135955|doi:10.1016/j.molstruc.2023.135955
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f58kg
title: CCDC 2239395: Experimental Crystal Structure Determination

description: Related Article: Xiaoxia Kong, Wei Gao, Kaiyi Li, Qinqin Shen, Tiantian Wan, Huilu Wu|2023|J.Mol.Struct.|1290|135947|doi:10.1016/j.molstruc.2023.135947
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f58lh
title: CCDC 2239396: Experimental Crystal Structure Determination

description: Related Article: Xiaoxia Kong, Wei Gao, Kaiyi Li, Qinqin Shen, Tiantian Wan, Huilu Wu|2023|J.Mol.Struct.|1290|135947|doi:10.1016/j.molstruc.2023.135947
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f94b7
title: CCDC 2243108: Experimental Crystal Structure Determination

description: Related Article: MOHD RAISH|2023|CSD Communication|||
description: Related Article: Mohd Raish, Mohammad Jane Alam, Musheer Ahmad, Shabbir Ahmad|2023|J.Mol.Struct.|1290|135975|doi:10.1016/j.molstruc.2023.135975
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.22820597
title: Supplementary Material for: Association Between Sleep Factors and Parkinson’s Disease: A Prospective Study Based On 409,923 UK Biobank Participants

description: Introduction: Limited evidence indicates an association between sleep factors and the risk of Parkinson’s disease (PD). However, large prospective cohort studies including both sexes are needed to verify the association between daytime sleepiness, sleep duration, and PD risk. Furthermore, other sleep factors like chronotype and snoring and their impact on increased PD risk should be explored by simultaneously considering daytime sleepiness and snoring. Methods: This study included 409,923 participants from the UK Biobank. Data on five sleep factors (chronotype, sleep duration, sleeplessness/insomnia, snoring, and daytime sleepiness) were collected using a standard self-administered questionnaire. PD occurrence was identified using linkages with primary care, hospital admission, death register, or self-report. Cox proportional hazard models were used to investigate the association between sleep factors and PD risk. Subgroup (age and sex) and sensitivity analyses were performed. Results: During a median follow-up of 11.89 years, 2158 incident PD cases were documented. The main association analysis showed that prolonged sleep duration (hazard ratio [HR]: 1.20, 95% confidence interval [CI]: 1.05, 1.37) and occasional daytime sleepiness (HR: 1.15, 95%CI: 1.04, 1.26) increased the PD risk. Compared to those who self-reported never or rarely having sleeplessness/insomnia, participants who reported usually having sleeplessness/insomnia had a decreased risk of PD (HR: 0.85, 95%CI: 0.75, 0.96). Subgroup analysis revealed that women who self-reported no snoring had a decreased PD risk (HR: 0.84; 95%CI: 0.72, 0.99). Sensitivity analyses indicated that the robustness of the results was affected by potential reverse causation and data completeness. Conclusion: Long sleep duration increased the PD risk, especially among men and participants ≥60 years, while snoring increased the risk of PD in women. Additional studies are needed to i) further consider other sleep traits (e.g., rapid eye movement sleep behaviour disorder and sleep apnoea) that might be related to PD, ii) objectively measure sleep-related exposure, and iii) confirm the effects of snoring on PD risk by considering the impact of obstructive sleep apnoea and investigating its underlying mechanisms.
DOI: 10.6084/m9.figshare.22820597.v1
title: Supplementary Material for: Association Between Sleep Factors and Parkinson’s Disease: A Prospective Study Based On 409,923 UK Biobank Participants

description: Introduction: Limited evidence indicates an association between sleep factors and the risk of Parkinson’s disease (PD). However, large prospective cohort studies including both sexes are needed to verify the association between daytime sleepiness, sleep duration, and PD risk. Furthermore, other sleep factors like chronotype and snoring and their impact on increased PD risk should be explored by simultaneously considering daytime sleepiness and snoring. Methods: This study included 409,923 participants from the UK Biobank. Data on five sleep factors (chronotype, sleep duration, sleeplessness/insomnia, snoring, and daytime sleepiness) were collected using a standard self-administered questionnaire. PD occurrence was identified using linkages with primary care, hospital admission, death register, or self-report. Cox proportional hazard models were used to investigate the association between sleep factors and PD risk. Subgroup (age and sex) and sensitivity analyses were performed. Results: During a median follow-up of 11.89 years, 2158 incident PD cases were documented. The main association analysis showed that prolonged sleep duration (hazard ratio [HR]: 1.20, 95% confidence interval [CI]: 1.05, 1.37) and occasional daytime sleepiness (HR: 1.15, 95%CI: 1.04, 1.26) increased the PD risk. Compared to those who self-reported never or rarely having sleeplessness/insomnia, participants who reported usually having sleeplessness/insomnia had a decreased risk of PD (HR: 0.85, 95%CI: 0.75, 0.96). Subgroup analysis revealed that women who self-reported no snoring had a decreased PD risk (HR: 0.84; 95%CI: 0.72, 0.99). Sensitivity analyses indicated that the robustness of the results was affected by potential reverse causation and data completeness. Conclusion: Long sleep duration increased the PD risk, especially among men and participants ≥60 years, while snoring increased the risk of PD in women. Additional studies are needed to i) further consider other sleep traits (e.g., rapid eye movement sleep behaviour disorder and sleep apnoea) that might be related to PD, ii) objectively measure sleep-related exposure, and iii) confirm the effects of snoring on PD risk by considering the impact of obstructive sleep apnoea and investigating its underlying mechanisms.
DOI: 10.17632/st7ggs4s92.1
title: Interfering with the ERC1–LL5beta interaction disrupts plasma membrane–associated platforms and affects tumor cell motility

description: DOI: 10.1371/journal.pone.0287670
Cell migration requires a complex array of molecular events to promote protrusion at the front of motile cells. The scaffold protein LL5beta interacts with the scaffold ERC1, and recruits it at plasma membrane–associated platforms that form at the front of migrating tumor cells. LL5beta and ERC1 proteins support protrusion during migration as shown by the finding that depletion of either endogenous protein impairs tumor cell motility and invasion. In this study we have tested the hypothesis that interfering with the interaction between LL5beta and ERC1 may be used to interfere with the function of the endogenous proteins to inhibit tumor cell migration. For this, we identified ERC1(270-370) and LL5beta(381-510) as minimal fragments required for the direct interaction between the two proteins. The biochemical characterization demonstrated that the specific regions of the two proteins, including predicted intrinsically disordered regions, are implicated in a reversible, high affinity direct heterotypic interaction. NMR spectroscopy further confirmed the disordered nature of the two fragments and also support the occurrence of interaction between them. We tested if the LL5beta protein fragment interferes with the formation of the complex between the two full-length proteins. Coimmunoprecipitation experiments showed that LL5beta(381-510) hampers the formation of the complex in cells. Moreover, expression of either fragment is able to specifically delocalize endogenous ERC1 from the edge of migrating MDA-MB-231 tumor cells. Coimmunoprecipitation experiments show that the ERC1-binding fragment of LL5beta interacts with endogenous ERC1 and interferes with the binding of endogenous ERC1 to full length LL5beta. Expression of LL5beta(381-510) affects tumor cell motility with a reduction in the density of invadopodia and inhibits transwell invasion. These results provide a proof of principle that interfering with heterotypic intermolecular interactions between components of plasma membrane–associated platforms forming at the front of tumor cells may represent a new approach to inhibit cell invasion.
DOI: 10.26208/144h-0x26
title: Impacts of projected Arctic sea ice loss on daily weather patterns over North America

description: Future Arctic sea ice loss has a known impact on Arctic Amplification (AA) and mean atmospheric circulation. Furthermore, several studies have shown it leads to a decreased variance in temperature over North America. In this study, we analyze results from two fully-coupled Community Earth System Model (CESM) Whole Atmosphere Community Climate Model (WACCM4) simulations with sea ice nudged to either the ensemble mean of WACCM historical runs averaged over the 1980-1999 period for the control (CTL) or projected RCP8.5 values over the 2080-2099 period for the experiment (EXP). Dominant large-scale meteorological patterns (LSMPs) are then identified using self-organizing maps applied to winter daily 500 hPa geopotential height anomalies (Z500′) over North America. We investigate how sea ice loss (EXP-CTL) impacts the frequency of these LSMPs and, through composite analysis, the sensible weather associated with them.  We find differences LSMP frequency but no change in residency time indicating there is no stagnation of the flow with sea ice loss.  Sea ice loss also acts to de-amplify and/or shift the Z500′ that characterize these LSMPs and their associated anomalies in potential temperature at 850hPa.  Impacts on anomalous precipitation are more localized and consistent with changes in anomalous sea level pressure.  With this LSMP framework we provide new mechanistic insights, demonstrating a role for thermodynamic, dynamic and diabatic processes in sea ice impacts on atmospheric variability. Understanding these processes from a synoptic perspective is critical as some LSMPs play an outsized role in producing the mean response to Arctic sea ice loss.
DOI: 10.5281/zenodo.4456646
title: The relocated catalog of the 2021 Mamuju-Majene earthquakes

description: The relocated catalog of the 2021 Mamuju-Majene earthquakes. Please refer to: Supendi, P., Ramdhan, M., Priyobudi., Sianipar, D., Wibowo, A., Gunawan, M.T., Rohadi, S., Riama, N.F., Daryono, Prayitno, B.S., Murjaya, J., Karnawati, D., Meilano, I., Rawlinson, N., Widiyantoro, S., Nugraha, A.D., Marliyani, G.I., Palgunadi, K.H., Elsera, E.M. (2021). Foreshock-mainshock-aftershock sequence analysis of the 14 January 2021 (Mw 6.2) Mamuju-Majene (West Sulawesi, Indonesia). Earth Planets Space 73, 106, https://doi.org/10.1186/s40623-021-01436-x
DOI: 10.48677/02fac840-166a-4f60-ae43-4ab36100d5da
title: ALS DSM CRS3035RES50000mN2550000E4650000 Höhenraster 1m Stichtag 15.09.2022

description: Das Digitale Oberflächenmodell (DOM, engl.: DSM) beschreibt die Erdoberfläche samt allen darauf befindlichen Objekten in Form von Punktmengen, die in einem regelmäßigen Gitter angeordnet und in Lage und Höhe georeferenziert sind. Im Unterschied zum digitalen Geländemodell (DGM) wird somit die Vegetations- und Bebauungsoberfläche dargestellt. Dies ist eine von insgesamt 55 Kacheln, welche zusammen das Gebiet Österreich abdecken.
DOI: 10.5281/zenodo.6592435
title: The relocated catalog of the 2021 Flores Sea earthquake

description: The relocated catalog of the 2021 Flores Sea earthquakes Please refer to: Supendi, P., Rawlinson, N., Prayitno, B.S., Widiyantoro, S., Simanjuntak, A., Palgunadi, K.H., Kurniawan, A., Marliyani, G.I., Nugraha, A.D., Daryono, D., Anugrah, S.D., Fatchurochman, I., Gunawan, M.T., Sadly, M., Adi, S.P., Karnawati, D., Arimuko, A. (2022). The Kalaotoa Fault: A newly identified fault that generated the Mw 7.3 Flores Sea Earthquake. The Seismic Record (2022) 2 (3): 176–185.
DOI: 10.5281/zenodo.6592434
title: The relocated catalog of the 2021 Flores Sea earthquake

description: The relocated catalog of the 2021 Flores Sea earthquakes Please refer to: Supendi, P., Rawlinson, N., Prayitno, B.S., Widiyantoro, S., Simanjuntak, A., Palgunadi, K.H., Kurniawan, A., Marliyani, G.I., Nugraha, A.D., Daryono, D., Anugrah, S.D., Fatchurochman, I., Gunawan, M.T., Sadly, M., Adi, S.P., Karnawati, D., Arimuko, A. (2022). The Kalaotoa Fault: A newly identified fault that generated the Mw 7.3 Flores Sea Earthquake. The Seismic Record (2022) 2 (3): 176–185.
DOI: 10.48677/4e55bb0a-d6d1-4726-81ec-dffad23bbd40
title: ALS DSM CRS3035RES50000mN2600000E4300000 Höhenraster 1m Stichtag 15.09.2022

description: Das Digitale Oberflächenmodell (DOM, engl.: DSM) beschreibt die Erdoberfläche samt allen darauf befindlichen Objekten in Form von Punktmengen, die in einem regelmäßigen Gitter angeordnet und in Lage und Höhe georeferenziert sind. Im Unterschied zum digitalen Geländemodell (DGM) wird somit die Vegetations- und Bebauungsoberfläche dargestellt. Dies ist eine von insgesamt 55 Kacheln, welche zusammen das Gebiet Österreich abdecken.
DOI: 10.5281/zenodo.7096483
title: The relocated catalog of the 2022 Pasaman (West Sumatra) earthquake

description: The relocated catalog of the 2022 Pasaman (West Sumatra) earthquake Please refer to: Supendi, P., Rawlinson, N., Prayitno, B.S., Sianipar, D., Simanjuntak, A., Widiyantoro, S., Palgunadi, K.H., Kurniawan, A., Shiddiqi, H.A., Nugraha, A.D., Sahara, D.P., Daryono, D., Triyono, R., Adi, S.P., Karnawati, D., Daniarsyad, G., Ahadi, S., Fatchurochman, I., Anugrah, S.D., Heryandoko, N., Sudrajat, A. (2022). A hidden fault revealed by the February 25, 2022 (Mw 6.1) Pasaman Earthquake, West Sumatra, Indonesia, Physics of the Earth and Planetary Interiors, 106973. https://doi.org/10.1016/j.pepi.2022.106973
DOI: 10.5281/zenodo.7096482
title: The relocated catalog of the 2022 Pasaman (West Sumatra) earthquake

description: The relocated catalog of the 2022 Pasaman (West Sumatra) earthquake Please refer to: Supendi, P., Rawlinson, N., Prayitno, B.S., Sianipar, D., Simanjuntak, A., Widiyantoro, S., Palgunadi, K.H., Kurniawan, A., Shiddiqi, H.A., Nugraha, A.D., Sahara, D.P., Daryono, D., Triyono, R., Adi, S.P., Karnawati, D., Daniarsyad, G., Ahadi, S., Fatchurochman, I., Anugrah, S.D., Heryandoko, N., Sudrajat, A. (2022). A hidden fault revealed by the February 25, 2022 (Mw 6.1) Pasaman Earthquake, West Sumatra, Indonesia, Physics of the Earth and Planetary Interiors, 106973. https://doi.org/10.1016/j.pepi.2022.106973
DOI: 10.48677/e9f5b3f3-cc5c-4996-8ba1-eb15580cf023
title: ALS DSM CRS3035RES50000mN2600000E4350000 Höhenraster 1m Stichtag 15.09.2022

description: Das Digitale Oberflächenmodell (DOM, engl.: DSM) beschreibt die Erdoberfläche samt allen darauf befindlichen Objekten in Form von Punktmengen, die in einem regelmäßigen Gitter angeordnet und in Lage und Höhe georeferenziert sind. Im Unterschied zum digitalen Geländemodell (DGM) wird somit die Vegetations- und Bebauungsoberfläche dargestellt. Dies ist eine von insgesamt 55 Kacheln, welche zusammen das Gebiet Österreich abdecken.