cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11784360.v1
title: Additional file 1 of Multi-dimensional omics characterization in glioblastoma identifies the purity-associated pattern and prognostic gene signatures

description: Additional file 1: Table S1. The purity values in TCGA-GBM cohort. Table S2. Cox proportional hazards model in TCGA-GBM cohort. Table S3. Differentially expressed genes between tumor and normal samples. Table S4. Expression of Immune checkpoint molecules before and after purity adjustment. Table S5. Differentially mutated gene frequency in oncogenic signaling pathways.
DOI: 10.6084/m9.figshare.23304931.v1
title: Additional file 3 of Upper brainstem cholinergic neurons project to ascending and descending circuits

description: Additional file 3: Table 2. Quantification of axonal terminals in the thalamus.
DOI: 10.6084/m9.figshare.23304928
title: Additional file 2 of Upper brainstem cholinergic neurons project to ascending and descending circuits

description: Additional file 2: Table 1. Quantification of reconstruction neurons.
DOI: 10.6084/m9.figshare.24126511
title: Estimation of volatile organic compound exposure concentrations and time to reach a specific dermal absorption using physiologically based pharmacokinetic modeling

description: A procedure was proposed to estimate dermal exposures based on a physiologically based pharmacokinetic (PBPK) model developed in rats. The study examined vapor concentrations ranging from 500 to 10,000 ppm for dibromomethane and 2,500 to 40,000 ppm for bromochloromethane. These concentrations were reconstructed based on chemical blood levels measured in 4 hr, with errors varying from 0.0% to 52.0%. The PBPK approach adequately predicted the blood concentrations and helped simulate contaminant transport through the stratum corneum and distribution in the body compartments. The proposed technique made it possible to estimate the skin absorption time (SAT) obtained from acute inhalation toxicity data. An inverse relationship exists between the SAT and exposure concentration. The method can be helpful in toxicology and risk assessment of hazardous volatile organic compounds.
DOI: 10.6084/m9.figshare.24188511
title: Cost-effectiveness of somatrogon in the Spanish pediatric population with growth hormone deficiency

description: To analyze the cost-effectiveness of weekly somatrogon compared to daily growth hormones (GH-d) in the pediatric population of Spain with growth hormone deficiency (GHD). Markov model with two states (patients with or without GH-d or somatrogon treatment) in prepubertal children (3 to 11 years and 3 to 12 years in girls and boys, respectively) with GHD in isolation or as part of multiple pituitary hormone deficiency and without previous treatment, from the perspective of the National Health System. The simulation of the economic model ends at the age of 18. The costs of hormones and monitoring were obtained from Spanish sources. The utilities were obtained from the literature. Spanish clinical experts validated the assumptions of the model. In the deterministic analysis, somatrogon would be cost-effective, compared to GH-d, with a cost per QALY (quality-adjusted life year) gained of €19,259 and a clinically relevant QALY gain (0.336). This result was confirmed in deterministic sensitivity analyses. According to the probabilistic analysis, somatrogon would be the dominant treatment, with a 61% probability of a willingness to pay of €25,000 per QALY gained. Compared to GH-d, somatrogon is cost-effective in the Spanish pediatric population with GHD.
DOI: 10.6084/m9.figshare.24188511.v1
title: Cost-effectiveness of somatrogon in the Spanish pediatric population with growth hormone deficiency

description: To analyze the cost-effectiveness of weekly somatrogon compared to daily growth hormones (GH-d) in the pediatric population of Spain with growth hormone deficiency (GHD). Markov model with two states (patients with or without GH-d or somatrogon treatment) in prepubertal children (3 to 11 years and 3 to 12 years in girls and boys, respectively) with GHD in isolation or as part of multiple pituitary hormone deficiency and without previous treatment, from the perspective of the National Health System. The simulation of the economic model ends at the age of 18. The costs of hormones and monitoring were obtained from Spanish sources. The utilities were obtained from the literature. Spanish clinical experts validated the assumptions of the model. In the deterministic analysis, somatrogon would be cost-effective, compared to GH-d, with a cost per QALY (quality-adjusted life year) gained of €19,259 and a clinically relevant QALY gain (0.336). This result was confirmed in deterministic sensitivity analyses. According to the probabilistic analysis, somatrogon would be the dominant treatment, with a 61% probability of a willingness to pay of €25,000 per QALY gained. Compared to GH-d, somatrogon is cost-effective in the Spanish pediatric population with GHD.
DOI: 10.6084/m9.figshare.24431042
title: Visualizing the NIOSH Pocket Guide: Open-source web application for accessing and exploring the NIOSH Pocket Guide to Chemical Hazards

description: The NIOSH Pocket Guide to Chemical Hazards is a trusted resource that displays key information for a collection of chemicals commonly encountered in the workplace. Entries contain chemical structures—occupational exposure limit information ranging from limits based on full-shift time-weighted averages to acute limits such as short-term exposure limits and immediately dangerous to life or health values, as well as a variety of other data such as chemical-physical properties and symptoms of exposure. The NIOSH Pocket Guide (NPG) is available as a printed, hardcopy book, a PDF version, an electronic database, and a downloadable application for mobile phones. All formats of the NIOSH Pocket Guide allow users to access the data for each chemical separately, however, the guide does not support data analytics or visualization across chemicals. This project reformatted existing data in the NPG to make it searchable and compatible with exploration and analysis using a web application. The resulting application allows users to investigate the relationships between occupational exposure limits, the range and distribution of occupational exposure limits, and the specialized sorting of chemicals by health endpoint or to summarize information of particular interest. These tasks would have previously required manual extraction of the data and analysis. The usability of this application was evaluated among industrial hygienists and researchers and while the existing application seems most relevant to researchers, the open-source code and data are amenable to modification by users to increase customization.
DOI: 10.6084/m9.figshare.24431042.v3
title: Visualizing the NIOSH Pocket Guide: Open-source web application for accessing and exploring the NIOSH Pocket Guide to Chemical Hazards

description: The NIOSH Pocket Guide to Chemical Hazards is a trusted resource that displays key information for a collection of chemicals commonly encountered in the workplace. Entries contain chemical structures—occupational exposure limit information ranging from limits based on full-shift time-weighted averages to acute limits such as short-term exposure limits and immediately dangerous to life or health values, as well as a variety of other data such as chemical-physical properties and symptoms of exposure. The NIOSH Pocket Guide (NPG) is available as a printed, hardcopy book, a PDF version, an electronic database, and a downloadable application for mobile phones. All formats of the NIOSH Pocket Guide allow users to access the data for each chemical separately, however, the guide does not support data analytics or visualization across chemicals. This project reformatted existing data in the NPG to make it searchable and compatible with exploration and analysis using a web application. The resulting application allows users to investigate the relationships between occupational exposure limits, the range and distribution of occupational exposure limits, and the specialized sorting of chemicals by health endpoint or to summarize information of particular interest. These tasks would have previously required manual extraction of the data and analysis. The usability of this application was evaluated among industrial hygienists and researchers and while the existing application seems most relevant to researchers, the open-source code and data are amenable to modification by users to increase customization.
DOI: 10.6084/m9.figshare.24126511.v2
title: Estimation of volatile organic compound exposure concentrations and time to reach a specific dermal absorption using physiologically based pharmacokinetic modeling

description: A procedure was proposed to estimate dermal exposures based on a physiologically based pharmacokinetic (PBPK) model developed in rats. The study examined vapor concentrations ranging from 500 to 10,000 ppm for dibromomethane and 2,500 to 40,000 ppm for bromochloromethane. These concentrations were reconstructed based on chemical blood levels measured in 4 hr, with errors varying from 0.0% to 52.0%. The PBPK approach adequately predicted the blood concentrations and helped simulate contaminant transport through the stratum corneum and distribution in the body compartments. The proposed technique made it possible to estimate the skin absorption time (SAT) obtained from acute inhalation toxicity data. An inverse relationship exists between the SAT and exposure concentration. The method can be helpful in toxicology and risk assessment of hazardous volatile organic compounds.
DOI: 10.6084/m9.figshare.24239470
title: Industry-wide review of potential worker exposure to 1,3-butadiene during chemical manufacturing and processing as a reactant

description: Among the first 20 high-priority chemical substances selected by USEPA to undergo risk evaluation as part of the Toxic Substances Control Act, as amended by the Frank R. Lautenberg Chemical Safety for the 21<sup>st</sup> Century Act of 2016 is 1,3-butadiene (1,3-BD). Because much of the literature related to occupational exposure to 1,3-BD is associated with the use of the substance in synthetic rubber production and few data have been published for exposures to 1,3-BD manufacturing workers, existing industrial hygiene data collected at facilities where the substance is manufactured or processed as a reactant were compiled and analyzed. The dataset was comprised of personal air samples collected between 2010 and 2019 at facilities located throughout the United States and was compiled into a single database using a uniform data collection template. Data designated by the companies as full-shift were stratified by job group and one of three operational conditions of the workplace: routine, turnaround, and non-routine. Data designated by the companies as short-term and task-level were stratified by task description, sample duration, and operational condition. The final aggregated database contained a total of 5,676 full-shift personal samples. Mean concentrations of 1,3-BD for the job groups ranged from 0.012 ppm to 0.16 ppm. High-end estimates of 1,3-BD air concentrations for the job groups under routine operations ranged from 0.014 ppm to 0.23 ppm. The aggregated database also included 1,063 short-term and task-level personal samples. For short-term samples (&lt; =15 min), mean concentrations ranged from 0.49 ppm to 3.9 ppm, with the highest concentrations observed for the cleaning and maintaining equipment tasks. For task samples with durations greater than 15 min, mean concentrations ranged from 0.49 to 3.6 ppm, with the highest concentrations observed for the unloading and loading task. In addition to the personal air sampling records, information on the use of PPE during various tasks was compiled and analyzed. This data set provides robust quantitative air concentration data and exposure control information for which occupational exposures to 1,3-BD in the Manufacturing and Processing as a Reactant condition of use can be assessed.
DOI: 10.6084/m9.figshare.24239470.v2
title: Industry-wide review of potential worker exposure to 1,3-butadiene during chemical manufacturing and processing as a reactant

description: Among the first 20 high-priority chemical substances selected by USEPA to undergo risk evaluation as part of the Toxic Substances Control Act, as amended by the Frank R. Lautenberg Chemical Safety for the 21<sup>st</sup> Century Act of 2016 is 1,3-butadiene (1,3-BD). Because much of the literature related to occupational exposure to 1,3-BD is associated with the use of the substance in synthetic rubber production and few data have been published for exposures to 1,3-BD manufacturing workers, existing industrial hygiene data collected at facilities where the substance is manufactured or processed as a reactant were compiled and analyzed. The dataset was comprised of personal air samples collected between 2010 and 2019 at facilities located throughout the United States and was compiled into a single database using a uniform data collection template. Data designated by the companies as full-shift were stratified by job group and one of three operational conditions of the workplace: routine, turnaround, and non-routine. Data designated by the companies as short-term and task-level were stratified by task description, sample duration, and operational condition. The final aggregated database contained a total of 5,676 full-shift personal samples. Mean concentrations of 1,3-BD for the job groups ranged from 0.012 ppm to 0.16 ppm. High-end estimates of 1,3-BD air concentrations for the job groups under routine operations ranged from 0.014 ppm to 0.23 ppm. The aggregated database also included 1,063 short-term and task-level personal samples. For short-term samples (&lt; =15 min), mean concentrations ranged from 0.49 ppm to 3.9 ppm, with the highest concentrations observed for the cleaning and maintaining equipment tasks. For task samples with durations greater than 15 min, mean concentrations ranged from 0.49 to 3.6 ppm, with the highest concentrations observed for the unloading and loading task. In addition to the personal air sampling records, information on the use of PPE during various tasks was compiled and analyzed. This data set provides robust quantitative air concentration data and exposure control information for which occupational exposures to 1,3-BD in the Manufacturing and Processing as a Reactant condition of use can be assessed.
DOI: 10.6084/m9.figshare.11784402
title: Additional file 1 of Radiological measurement of pelvic fractures using a pelvic deformity measurement software program

description: Additional file 1. The pelvic deformity measurement software program. (RAR 929 kb)
DOI: 10.6084/m9.figshare.11784402.v1
title: Additional file 1 of Radiological measurement of pelvic fractures using a pelvic deformity measurement software program

description: Additional file 1. The pelvic deformity measurement software program. (RAR 929 kb)
DOI: 10.6084/m9.figshare.11784405
title: Additional file 1 of Genomic subtyping of liver cancers with prognostic application

description: Additional file 1. Supplementary Tables S1-S6. Table S1. Clinical and pathological information on 110-Liver cohort. Table S2. SNV numbers in different sequence datasets on 110-Liver cohort. Table S3. Survival analysis of clinical and genomic factors for patients in different cohorts of liver cancers. Table S4. Clinical and pathological information on 15 Chinese HCC patients. Table S5. Association between characteristics of somatic variations and clinical features in different cohorts of liver cancers. Table S6. Experimental AluScan analysis of 15 Chinese HCC patients.
DOI: 10.6084/m9.figshare.11784405.v1
title: Additional file 1 of Genomic subtyping of liver cancers with prognostic application

description: Additional file 1. Supplementary Tables S1-S6. Table S1. Clinical and pathological information on 110-Liver cohort. Table S2. SNV numbers in different sequence datasets on 110-Liver cohort. Table S3. Survival analysis of clinical and genomic factors for patients in different cohorts of liver cancers. Table S4. Clinical and pathological information on 15 Chinese HCC patients. Table S5. Association between characteristics of somatic variations and clinical features in different cohorts of liver cancers. Table S6. Experimental AluScan analysis of 15 Chinese HCC patients.
DOI: 10.6084/m9.figshare.11784417
title: Additional file 11 of Characterization of wheat homeodomain-leucine zipper family genes and functional analysis of TaHDZ5-6A in drought tolerance in transgenic Arabidopsis

description: Additional file 11: Table S3. Genes up or downregulated in 35S:TaHDZ5-6A transgenic Arabidopsis relative to WT plants under well-watered condition. Genes with an average fold change (FC) &gt; 2.0 and a corrected-P &lt; 0.001 are shown. The gene functional description is based on TAIR 10.
DOI: 10.6084/m9.figshare.11784417.v1
title: Additional file 11 of Characterization of wheat homeodomain-leucine zipper family genes and functional analysis of TaHDZ5-6A in drought tolerance in transgenic Arabidopsis

description: Additional file 11: Table S3. Genes up or downregulated in 35S:TaHDZ5-6A transgenic Arabidopsis relative to WT plants under well-watered condition. Genes with an average fold change (FC) &gt; 2.0 and a corrected-P &lt; 0.001 are shown. The gene functional description is based on TAIR 10.
DOI: 10.6084/m9.figshare.11784423
title: Additional file 3 of Genomic subtyping of liver cancers with prognostic application

description: Additional file 3. Supplementary Data S1. Exome-subset regions in BED format.
DOI: 10.6084/m9.figshare.11784423.v1
title: Additional file 3 of Genomic subtyping of liver cancers with prognostic application

description: Additional file 3. Supplementary Data S1. Exome-subset regions in BED format.
DOI: 10.6084/m9.figshare.11784426
title: Additional file 12 of Characterization of wheat homeodomain-leucine zipper family genes and functional analysis of TaHDZ5-6A in drought tolerance in transgenic Arabidopsis

description: Additional file 12: Table S4. Primers used in this research. The name of the primers was based on the gene name and experimental purpose.
DOI: 10.6084/m9.figshare.11784426.v1
title: Additional file 12 of Characterization of wheat homeodomain-leucine zipper family genes and functional analysis of TaHDZ5-6A in drought tolerance in transgenic Arabidopsis

description: Additional file 12: Table S4. Primers used in this research. The name of the primers was based on the gene name and experimental purpose.
DOI: 10.6084/m9.figshare.11784432
title: Additional file 4 of Genomic subtyping of liver cancers with prognostic application

description: Additional file 4. Supplementary Data S2. AluScan-subset regions in BED format.
DOI: 10.6084/m9.figshare.11784432.v1
title: Additional file 4 of Genomic subtyping of liver cancers with prognostic application

description: Additional file 4. Supplementary Data S2. AluScan-subset regions in BED format.
DOI: 10.6084/m9.figshare.11784453
title: Additional file 3 of Characterization of wheat homeodomain-leucine zipper family genes and functional analysis of TaHDZ5-6A in drought tolerance in transgenic Arabidopsis

description: Additional file 3: Table S1. FPKM (Fragments Per Kilobase Million) values of the TaHDZ genes in ten tissues and under drought stress treatment.
DOI: 10.6084/m9.figshare.11784453.v1
title: Additional file 3 of Characterization of wheat homeodomain-leucine zipper family genes and functional analysis of TaHDZ5-6A in drought tolerance in transgenic Arabidopsis

description: Additional file 3: Table S1. FPKM (Fragments Per Kilobase Million) values of the TaHDZ genes in ten tissues and under drought stress treatment.
DOI: 10.6084/m9.figshare.19634933.v1
title: Additional file 6 of Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L.

description: Additional file 6: Figure S2. The correlation analysis between 3 different tissues and expression patterns of the 11 Nicotiana tabacum L. bZIP genes under abiotic stresses.
DOI: 10.15156/bio/sh1748342.08fu
title: SH1748342.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh1748343.08fu
title: SH1748343.08FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh382690.07fu
title: SH382690.07FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.