cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13012/b2idb-5457902_v1
title: Data for "Crop-specific exposure to extreme temperature and moisture for the globe for the last half century"

description: Global assessments of climate extremes typically do not account for the unique characteristics of individual crops. A consistent definition of the exposure of specific crops to extreme weather would enable agriculturally-relevant hazard quantification. We introduce the Agriculturally-Relevant Exposure to Shocks (ARES) model, a novel database of both the temperature and moisture extremes facing individual crops by explicitly accounting for crop characteristics. Specifically, we estimate crop-specific temperature and moisture shocks during the growing season for a 0.25-degree spatial grid and daily time scale from 1961-2014 globally for 17 crops. The resulting database presented here provides annual crop- and event-specific exposure rates. Both gridded and country-level exposure rates are provided for each of the 17 crops. Our results provide new insights into the changes in the magnitude as well as spatial and temporal distribution of extreme events that impact crops over the past half-century. For additional information, please see the related paper by Jackson et al. (2021) in Environmental Research Letters.
DOI: 10.5281/zenodo.8320202
title: Biomechanical variables and pelvic kinematics in lower limb amputees

description: Lower limb amputation causes drastic changes in basic locomotion patterns. Currently, these patterns are analyzed using a wide variety of methods, with a focus on different variables that can describe their impact on gait conditions and normal posture. Evaluating these conditions is of paramount importance because restoring a normal gait constitutes a key objective in the physical rehabilitation of amputees. Moreover, such assessments could potentially suggest different modifications to prosthetic devices. The objective is to provide a database with values of biomechanical parameters such as body weight distribution, pelvic kinematics, and gait measurements in above-knee (AK) and below-knee (BK) amputees. <br> The data are reported in a .CSV file and are organized according to the attendance of 29 patients to the tests. Each column has the information as follows: participant number; age; gender; weight; size; body mass index (BMI); amputation level; amputation laterality; amputation date; suspension system; body weight distribution percentage in each limb, the sound limb (BWD_S) and the prosthetic one (BWD_P) and the subtraction between both of them (BWD_S-P); gait velocity, cadence; two-minute walking test distance (2MWT) and stride length for each limb (STRIDE_S and STRIDE_P). <br> Also, some gait-related indexes as follows: gait symmetry index, which represents the difference between the value (expressed as a percentage) of the sound limb and that of the prosthetic limb in the stance or swing phases, denoted as SI; quality index, it evaluates individuals’ ability to correctly divide their own gait cycle between the sound and prosthetic limb steps, named as QI_S and QI_P respectively; propulsion index, it is computed based on the gradient (in degrees) between the start and end of the monopodal support phase in the anteroposterior acceleration graph for each limb during gait, and it is denoted as PROP_S and PROP_P.
description: {"references": ["C. H. da S. Fontes Filho et al., \"Bodyweight distribution between limbs, muscle strength, and proprioception in traumatic transtibial amputees: A cross-sectional study,\" Clinics, vol. 76, 2021, doi: 10.6061/CLINICS/2021/E2486.", "S. Winiarski, A. Rutkowska-Kucharska, and M. Kowal, \"Symmetry function as a new tool for evaluating the symmetry of gait in transfemoral amputees,\" 2020, doi: 10.21203/rs.3.rs-49948/v1.", "BTS Bioengineering, \"WALK Evaluaci\u00f3n de la coordinaci\u00f3n muscular durante la marcha,\" Quincy, Massachusetts, 2020. [Online]. Available: www.btsbioengineering.com", "BTS Bioengineering, \"WALK - Evaluaci\u00f3n de la coordinaci\u00f3n muscular durante la marcha - Manual de Usuario,\" 2020. [Online]. Available: www.btsbioengineering.com"]}
DOI: 10.6084/m9.figshare.24085518
title: data_bayraktar.xlsx

description: the data is quantative data and gathered from questionairies
DOI: 10.6084/m9.figshare.24085518.v1
title: data_bayraktar.xlsx

description: the data is quantative data and gathered from questionairies
DOI: 10.5281/zenodo.8320201
title: Biomechanical variables and pelvic kinematics in lower limb amputees

description: Lower limb amputation causes drastic changes in basic locomotion patterns. Currently, these patterns are analyzed using a wide variety of methods, with a focus on different variables that can describe their impact on gait conditions and normal posture. Evaluating these conditions is of paramount importance because restoring a normal gait constitutes a key objective in the physical rehabilitation of amputees. Moreover, such assessments could potentially suggest different modifications to prosthetic devices. The objective is to provide a database with values of biomechanical parameters such as body weight distribution, pelvic kinematics, and gait measurements in above-knee (AK) and below-knee (BK) amputees. <br> The data are reported in a .CSV file and are organized according to the attendance of 29 patients to the tests. Each column has the information as follows: participant number; age; gender; weight; size; body mass index (BMI); amputation level; amputation laterality; amputation date; suspension system; body weight distribution percentage in each limb, the sound limb (BWD_S) and the prosthetic one (BWD_P) and the subtraction between both of them (BWD_S-P); gait velocity, cadence; two-minute walking test distance (2MWT) and stride length for each limb (STRIDE_S and STRIDE_P). <br> Also, some gait-related indexes as follows: gait symmetry index, which represents the difference between the value (expressed as a percentage) of the sound limb and that of the prosthetic limb in the stance or swing phases, denoted as SI; quality index, it evaluates individuals’ ability to correctly divide their own gait cycle between the sound and prosthetic limb steps, named as QI_S and QI_P respectively; propulsion index, it is computed based on the gradient (in degrees) between the start and end of the monopodal support phase in the anteroposterior acceleration graph for each limb during gait, and it is denoted as PROP_S and PROP_P.
description: {"references": ["C. H. da S. Fontes Filho et al., \"Bodyweight distribution between limbs, muscle strength, and proprioception in traumatic transtibial amputees: A cross-sectional study,\" Clinics, vol. 76, 2021, doi: 10.6061/CLINICS/2021/E2486.", "S. Winiarski, A. Rutkowska-Kucharska, and M. Kowal, \"Symmetry function as a new tool for evaluating the symmetry of gait in transfemoral amputees,\" 2020, doi: 10.21203/rs.3.rs-49948/v1.", "BTS Bioengineering, \"WALK Evaluaci\u00f3n de la coordinaci\u00f3n muscular durante la marcha,\" Quincy, Massachusetts, 2020. [Online]. Available: www.btsbioengineering.com", "BTS Bioengineering, \"WALK - Evaluaci\u00f3n de la coordinaci\u00f3n muscular durante la marcha - Manual de Usuario,\" 2020. [Online]. Available: www.btsbioengineering.com"]}
DOI: 10.25607/ksdltq
title: DFO Pacific Outside North Hard Bottom Longline Surveys

description: The Outside North Hard Bottom Longline (HBLL) survey is one of a set of long-term and coordinated surveys that together cover most of the nearshore, hard-bottom habitat of coastal British Columbia. The other surveys are the Outside South HBLL survey, Inside North HBLL survey, and Inside South HBLL survey.
description: The Outside North HBLL survey was first conducted in 2006 and has been repeated every second year in alternate years to the Outside South HBLL survey, with the exception that no surveys were conducted in 2013. The survey was not impacted by the COVID-19 pandemic. The objective of these surveys is to provide fishery-independent abundance indices and associated biological data for the assessment of nearshore rockfishes and other groundfish species that live on untrawlable, hard bottom habitats. The surveys follow a random depth-stratified design and the sampling units are 2 km by 2 km blocks. The Outside HBLL surveys use size 14/0 circle hooks, baited with frozen squid.
description: The Outside North HBLL Survey is conducted by DFO in collaboration with the Pacific Halibut Management Association (PHMA) and takes place on several chartered commercial fishing vessels each year. This survey covers the northern portion of the British Columbia coastline, including the mainland coast north of Milbanke Sound, Dixon Entrance, and the east and west coasts of Haida Gwaii. The PHMA provides the chartered commercial fishing vessels and field technicians, while DFO provides support for running the surveys, including survey design and equipment.
description: The data provided include information about the annual survey trips and fishing events (tows/sets) that are part of this survey series, including the vessel name, dates, times, spatial coverage, gear details, and effort information. Catch information (total weight in kg or counts of individual specimens) is included from successful fishing events. Catches are identified to species or to the lowest taxonomic level possible. Most catches are weighed, but some are too small (“trace” amounts) or too large (e.g. very large Big Skate). Some catches were subsampled and biological data were collected from individual fish specimens, including length, sex, and weight information. Where age structures were collected and processed, fish ages have been included.
DOI: 10.6084/m9.figshare.20486806
title: Additional file 3 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy

description: Additional file 3.
DOI: 10.6084/m9.figshare.23632518.v1
title: Additional file 2 of Protocadherin 20 maintains intestinal barrier function to protect against Crohn’s disease by targeting ATF6

description: Additional file 2: Data S1 Interactors of PCDH20 downloaded from Biogrid.
DOI: 10.6084/m9.figshare.23632521.v1
title: Additional file 3 of Protocadherin 20 maintains intestinal barrier function to protect against Crohn’s disease by targeting ATF6

description: Additional file 3: Data S2 Enrichment of PCDH20 interactors using Metascape.
DOI: 10.6084/m9.figshare.12096588.v1
title: Additional file 3 of Predicting liver cytosol stability of small molecules

description: Additional file 3. External validation results.
DOI: 10.6084/m9.figshare.19962651
title: Safety assessment of multiple repeated percutaneous punctures for the collection of cerebrospinal fluid in rats

description: The objective of this study was to examine the safety of multiple repeated percutaneous punctures of cisterna magna for collecting cerebrospinal fluid (CSF) and preliminarily determine the optimal time interval and volume at each collection. Sixty Wistar rats were randomly assigned to six groups: 10 d-0 μL, 10 d-100 μL (100 μL CSF collected at an interval of 10 days), 10 d-150 μL, 15 d-0 μL, 15 d-100 μL, and 15 d-150 μL. CSF was collected by percutaneous puncture of the cisterna magna at four time-points. Simultaneously, locomotor activity, cisterna magna pressure, and acetylcholine levels in the CSF were monitored. Compared with the 10 d-0 μL group, the escape latency by Morris water maze was significantly prolonged in the 10 d-100 μL and 10 d-150 μL groups (P&lt;0.05). Compared with the 15 d-0 μL group, the indices of 15 d-100 μL and 15 d-150 μL groups had no significant differences. When compared with that at the first training, the exception of the 10 d-150 μL and 15 d-150 μL groups, significant differences in escape latency were found at the 6th attempt (P&lt;0.05). Compared with baseline readings for each group, the cisterna magna pressure in the 10 d-150 μL group began to decrease significantly from the third measurement (P&lt;0.05). The optimal time interval during four CSF collections (100 μL per collection) via cisterna magna percutaneous puncture was determined to be 15 days. The procedure did not significantly affect learning processes, performance, or other related indices.
DOI: 10.6084/m9.figshare.23632518
title: Additional file 2 of Protocadherin 20 maintains intestinal barrier function to protect against Crohn’s disease by targeting ATF6

description: Additional file 2: Data S1 Interactors of PCDH20 downloaded from Biogrid.
DOI: 10.6084/m9.figshare.25152251.v1
title: Supplementary Material for: Rare Delayed Ifosfamide Encephalopathy: A Case Report of Chemotherapeutic Neurotoxicity

description: <b><i>Introduction:</i></b> Neurotoxicity is a well-documented side effect of ifosfamide chemotherapy. The presentation includes hallucinations, seizures, disorientation, coma, and death. Treatment with methylene blue can shorten the duration and severity of symptoms. Ifosfamide neurotoxicity almost always happens during or shortly after drug infusion and so is usually immediately recognized. Here, we describe a case of ifosfamide neurotoxicity with onset 14 days after treatment started. <b><i>Case Presentation:</i></b> A 25-year-old woman with round cell sarcoma of the jaw presented to the emergency department with 2 days of encephalopathy and bizarre behavior. Antipsychotic medications and benzodiazepines produced no benefit. After consultation, oncology recommended methylene blue, hypothesizing that her symptoms could be a rare presentation of delayed ifosfamide-induced neurotoxicity, 14 days after first administration. After 4 days of methylene blue infusion, her functioning returned to baseline. <b><i>Conclusion:</i></b> Delayed ifosfamide-related neurotoxicity is a rare side effect of this chemotherapeutic agent and should be considered in the workup of altered mental status, even if symptoms occur after the previously accepted 5-day standard. In such patients, delayed symptomology may require extended use of methylene blue as treatment.
DOI: 10.6084/m9.figshare.19962672.v1
title: miR-141 is negatively correlated with TLR4 in neonatal sepsis and regulates LPS-induced inflammatory responses in monocytes

description: Neonatal sepsis is an inflammatory system syndrome and a main cause of neonatal mortality. However, there is a lack of ideal biomarkers for early neonatal sepsis diagnosis. The aim of this study was to evaluate the clinical significance of miR-141 in sepsis in neonates, and explore the regulatory effects of miR-141 on inflammation in monocytes. This study used qRT-PCR to calculate the expression of miR-141 in the serum of septic neonates. The diagnostic values of procalcitonin (PCT) and serum miR-141 were evaluated by receiver operating characteristic (ROC) curves. The relationship between miR-141 and TLR4 was determined using luciferase reporter assay. An inflammation model was established using monocytes with lipopolysaccharide (LPS) treatment. ELISA assay was used to analyze the levels of pro-inflammatory cytokines. The expression of miR-141 in neonatal sepsis was significantly lower than healthy controls. ROC curves showed that miR-141 had diagnostic accuracy. LPS stimulation in monocytes led to a decrease in the expression of miR-141. A luciferase reporter assay proved that miR-141 targeted TLR4, and a negative correlation of miR-141 with TLR4 was found in septic neonates. ELISA results demonstrated that the overexpression of miR-141 inhibited LPS-induced inflammation in monocytes. In conclusion, serum decreased miR-141 expression served as a candidate diagnostic biomarker of neonatal sepsis. TLR4 is a target gene of miR-141, which may mediate the inhibitory effects of miR-141 overexpression on LPS-induced inflammation in monocytes. Therefore, miR-141 is expected to be a potential diagnostic biomarker and a therapeutic target in neonatal sepsis.
DOI: 10.6084/m9.figshare.20486803.v1
title: Additional file 2 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy

description: Additional file 2.
DOI: 10.6084/m9.figshare.20486803
title: Additional file 2 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy

description: Additional file 2.
DOI: 10.6084/m9.figshare.20486806.v1
title: Additional file 3 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy

description: Additional file 3.
DOI: 10.6084/m9.figshare.21009522
title: Additional file 4 of OsFTL4, an FT-like Gene, Regulates Flowering Time and Drought Tolerance in Rice (Oryza sativa L.)

description: Additional file 4. Table S3: Primers used in this study.
DOI: 10.6084/m9.figshare.19962696
title: Stereotactic biopsy for lesions in brainstem and deep brain: a single-center experience of 72 cases

description: Stereotactic biopsies for lesions in the brainstem and deep brain are rare. This study aimed to summarize our 6-year experience in the accurate diagnosis of lesions in the brain stem and deep brain and to discuss the technical note and strategies. From December 2011 to January 2018, 72 cases of intracranial lesions in the brainstem or deep in the lobes undergoing stereotactic biopsy were retrospectively reviewed. An individualized puncture path was designed based on the lesion's location and the image characteristics. The most common biopsy targets were deep in the lobes (43 cases, 59.7%), including frontal lobe (33 cases, 45.8%), temporal lobe (4 cases, 5.6%), parietal lobe (3 cases, 4.2%), and occipital lobe (3 cases, 4.2 %). There were 12 cases (16.7%) of the brainstem, including 8 cases (11.1%) of midbrain, and 4 cases (5.6%) of pons or brachium pontis. Other targets included internal capsule (2 cases, 2.8%), thalamus (3 cases, 4.2%), and basal ganglion (12 cases, 16.7%). As for complications, one patient developed acute intracerebral hemorrhage in the biopsy area at 2 h post-operation, and one patient had delayed intracerebral hemorrhage at 7 days post-operation. The remaining patients recovered well after surgery. There was no surgery-related death. The CT-MRI-guided stereotactic biopsy of lesions in the brainstem or deep in the brain has the advantages of high safety, accurate diagnosis, and low incidence of complications. It plays a crucial role in the diagnosis of atypical, microscopic, diffuse, multiple, and refractory lesions.
DOI: 10.6084/m9.figshare.20486809
title: Additional file 4 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy

description: Additional file 4.
DOI: 10.6084/m9.figshare.20486809.v1
title: Additional file 4 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy

description: Additional file 4.
DOI: 10.6084/m9.figshare.21009519
title: Additional file 3 of OsFTL4, an FT-like Gene, Regulates Flowering Time and Drought Tolerance in Rice (Oryza sativa L.)

description: Additional file 3. Table S2: Predicted hormone-responsive elements in the OsFTL4 promoter.
DOI: 10.6084/m9.figshare.19962699.v1
title: Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages

description: Hypertrophic scar (HS) formation is a common complication that develops after skin injury; however, there are few effective and specific therapeutic approaches for HS. Emodin has previously been reported to inhibit mechanical stress-induced HS inflammation. Here, we investigated the molecular mechanisms underlying the inhibitory effects of emodin on HS formation. First, we conducted in vitro assays that revealed that emodin inhibited M1 and M2 polarization in rat macrophages. We subsequently established a combined rat model of tail HS and dorsal subcutaneous polyvinyl alcohol (PVA) sponge-induced wounds. Rats were treated with emodin or vehicle (DMEM). Tail scar specimens were harvested at 14, 28, and 42 days post-incision and subjected to H&E staining and Masson's trichrome staining. Histopathological analyses confirmed that emodin attenuated HS formation and fibrosis. Macrophages were separated from wound cells collected from the PVA sponge at 3 and 7 days after implantation. Flow cytometry analysis demonstrated that emodin suppressed in vivo macrophage recruitment and polarization at the wound site. Finally, we explored the molecular mechanisms of emodin in modulating macrophage polarization by evaluating the expression levels of selected effectors of the Notch and TGF-β pathways in macrophages isolated from PVA sponges. Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-β, and Smad3 were downregulated in response to emodin treatment. Taken together, our findings suggested that emodin attenuated HS formation and fibrosis by suppressing macrophage polarization, which is associated with the inhibition of the Notch and TGF-β pathways in macrophages.
DOI: 10.6084/m9.figshare.19962627
title: lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11

description: The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor suppressor, is critical for the carcinogenesis and progression of different cancers, including hepatocellular carcinoma (HCC). To date, the roles of lncRNA MEG3 in HCC are not well illustrated. Therefore, this study used western blot and qRT-PCR to evaluate the expression of MEG3, miR-9-5p, and Sex determining Region Y-related HMG-box 11 (SOX11) in HCC tissues and cell lines. RNA pull-down and luciferase reporter assay were used to evaluate these molecular interactions. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry detected the viability and apoptosis of HCC cells, respectively. The results showed that MEG3 and SOX11 were poorly expressed but miR-9-5p was highly expressed in HCC. The expression levels of these molecules suggested a negative correlation between MEG3 and miR-9-5p and a positive correlation with SOX11, confirmed by Pearson's correlation analysis and biology experiments. Furthermore, MEG3 could combine with miR-9-5p, and SOX11 was a direct target of miR-9-5p. Moreover, MEG3 over-expression promoted cell apoptosis and growth inhibition in HCC cells through sponging miR-9-5p to up-regulate SOX11. Therefore, the interactions among MEG3, miR-9-5p, and SOX11 might offer a novel insight for understanding HCC pathogeny and provide potential diagnostic markers and therapeutic targets for HCC.