DOI: 10.5281/zenodo.15747416
title: TRISTAN: Raw DICOM Archives for Preclinical Drug-Interaction Studies in Rats

description: TRISTAN: Preclinical Rat MRI (Raw DICOM)

This record contains original, unprocessed DICOM data from 15 preclinical rat studies (S01–S15) conducted within the TRISTAN project. Each study investigates drug–drug interactions or protocol effects under controlled conditions. Files are distributed as ZIP archives per study.

DOI: 10.5281/zenodo.17178063

Included studies





S01 – tristan_rats_study_01_rifampicin_effect_size




S02 – tristan_rats_study_02_rifampicin_effect_size




S03 – tristan_rats_study_03_rifampicin_effect_size




S04 – tristan_rats_study_04_rifampicin_effect_size




S05 – tristan_rats_study_05_single_asunaprevir




S06 – tristan_rats_study_06_single_pioglitazone




S07 – tristan_rats_study_07_single_ketoconazole




S08 – tristan_rats_study_08_single_cyclosporine




S09 – tristan_rats_study_09_single_bosentan_high




S10 – tristan_rats_study_10_single_bosentan




S11 – tristan_rats_study_11_chronic_bosentan_placebo




S12 – tristan_rats_study_12_single_rifampicin




S13 – tristan_rats_study_13_field_strength




S14 – tristan_rats_study_14_chronic_rifampicin_placebo




S15 – tristan_rats_study_15_chronic_cyclosporine_placebo



File structure. Each study ZIP contains nested ZIPs named like SXX_RatYY_DayZ.zip, i.e., scans from one rat on a given day. Data are raw DICOM only—no preprocessing.

Quick start (manual)





Download the study ZIP(s) you need (e.g., S01.zip).




Unzip; inside you’ll find multiple inner ZIPs per rat/day.




Unzip those to access the DICOM series.



Programmatic download (Python)

Use the tristan.rat_fetch function in the open-source miblab-data package to download, optionally recursively unzip, and (optionally) convert to NIfTI.

Related analyses and figures

Reproducible analysis code and generated figures: https://github.com/openmiblab/tristan-rat-analysis

Citation

Please cite this dataset as:

Teh, K., Sourbron, S., and the TRISTAN Consortium (2025). TRISTAN: Preclinical rat MRI (raw DICOM). Zenodo. https://doi.org/10.5281/zenodo.17178063

License

CC BY 4.0 — You are free to share and adapt the material with appropriate credit.

Contact

Kevin Teh University of Sheffield, Division of Clinical Medicine k.teh@sheffield.ac.uk
description: Study
Rat IDs
Treatment group
Day1
Day2
Day3/4
Notes


S01
01–03
Placebo group
Placebo
Placebo
 
 


S01
04–06
Rifampicin group
Placebo
Rifampicin
 
 


S02
01–03
Placebo group
Placebo
Placebo
 
 


S02
04–06
Rifampicin group
Placebo
Rifampicin
 
 


S03
05,10,11
Placebo group
Placebo
Placebo
 
 


S03
07–09
Rifampicin group
Placebo
Rifampicin
 
 


S04
01–04
Placebo group
Placebo
Placebo
 
 


S04
05–08
Rifampicin group
Placebo
Rifampicin
 
 


S05
01
Asunaprevir group
Placebo
—
 
Missing Day 2


S05
02–06
Asunaprevir group
Placebo
Asunaprevir
 
 


S06
01–06
Pioglitazone group
Placebo
Pioglitazone
 
 


S07
01
Ketoconazole group
Placebo
—
 
Missing Day 2


S07
02–06
Ketoconazole group
Placebo
Ketoconazole
 


S08
01–06
Cyclosporin group
Placebo
Cyclosporin
 
 


S09
01–03
Bosentan high group
Placebo
Bosentan high
 


S09
04
Bosentan high group
Placebo
—
 
Missing Day 2


S10
01–06
Bosentan group
Placebo
Bosentan
 
 


S11
01–06
Bosentan group
Placebo
Bosentan
 
Clinical dose


S12
01–04
Rifampicin group
Placebo
Rifampicin
 
 


S13
01–06
Placebo group
Placebo
Placebo
 
 


S14
03,06,09,12
Placebo group
Placebo
Placebo
Placebo
 


S14
01,04,07,10
Rifampicin clinical group
Placebo
Rifampicin clinical
Rifampicin clinical
Rat 10 missing Days 1–2


S14
02,05,08,11
Rifampicin high group
Placebo
Rifampicin high
Rifampicin high


S15
03,04,05,06,09,10
Placebo group
Placebo
Placebo
Placebo
 


S15
01,02,07,08,11,12,13
Cyclosporin group
Placebo
Cyclosporin
Cyclosporin
Rat 13 missing Day 3