cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7252169
title: Interleukin 5-producing ST2<sup>+</sup> memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis

description: <b>Objectives:</b> Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS). <b>Methods:</b> We separated and analyzed the proportion of growth stimulation expressed gene 2 (ST2)<sup>+</sup> memory Th2 cells among the peripheral blood mononuclear cells by flow cytometry in cases with IgG4-DS and healthy individuals. Finally, we identified the role of ST2<sup>+</sup> memory Th2 cells in the involved tissues. <b>Results:</b> The proportion of circulating ST2<sup>+</sup> memory Th2 cells was much higher in the patients with IgG4-DS than in the healthy controls. Abundant infiltration of ST2<sup>+</sup> memory Th2 cells was detected in the involved salivary glands and lymph nodes, and these cells produced interleukin-5. <b>Conclusion:</b> We demonstrated that there is an increase of interleukin-5 producing ST2<sup>+</sup> memory Th2 cells in the involved tissues in IgG4-DS. This subset of cells is considered to be an important player in inducing the inflammatory Th2 environment characteristic of IgG4-DS.
DOI: 10.6084/m9.figshare.7252169.v1
title: Interleukin 5-producing ST2<sup>+</sup> memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis

description: <b>Objectives:</b> Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS). <b>Methods:</b> We separated and analyzed the proportion of growth stimulation expressed gene 2 (ST2)<sup>+</sup> memory Th2 cells among the peripheral blood mononuclear cells by flow cytometry in cases with IgG4-DS and healthy individuals. Finally, we identified the role of ST2<sup>+</sup> memory Th2 cells in the involved tissues. <b>Results:</b> The proportion of circulating ST2<sup>+</sup> memory Th2 cells was much higher in the patients with IgG4-DS than in the healthy controls. Abundant infiltration of ST2<sup>+</sup> memory Th2 cells was detected in the involved salivary glands and lymph nodes, and these cells produced interleukin-5. <b>Conclusion:</b> We demonstrated that there is an increase of interleukin-5 producing ST2<sup>+</sup> memory Th2 cells in the involved tissues in IgG4-DS. This subset of cells is considered to be an important player in inducing the inflammatory Th2 environment characteristic of IgG4-DS.
DOI: 10.6084/m9.figshare.7252166
title: Safety and effectiveness of abatacept in Japanese non-elderly and elderly patients with rheumatoid arthritis in an all-cases post-marketing surveillance

description: <b>Objectives:</b> To investigate the safety, effectiveness, and risk-benefit balance of intravenous abatacept (ABA) in non-elderly (&lt;65 years: NEG) and elderly (≥65 years: EG) rheumatoid arthritis patients. <b>Methods:</b> This sub-analysis of an all-cases postmarketing surveillance in Japan assessed safety in all enrolled patients and effectiveness in those with Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) measurements at ≥2 time points including baseline. Risk-benefit was evaluated based on infections and DAS28-CRP improvement &gt;1.2. <b>Results:</b> The NEG and EG of the safety analysis set comprised 2,170 and 1,712 patients, respectively; corresponding 6-month ABA retention rates were 80.2% and 77.1%. The NEG had fewer adverse drug reactions (14.5% vs. 17.2%, <i>p</i> = .021) and infections (4.8% vs. 7.2%, <i>p</i> = .002) than the EG. DAS28-CRP changed similarly between groups. The proportion of patients with low-risk/high-benefit and high-risk/low-benefit were 33.1% and 6.9% (NEG) and 29.7% and 9.0% (EG). Low-risk/high-benefit patients were younger, had shorter disease duration and fewer comorbidities, and were with less use of oral glucocorticoid and prior biologics, more use of methotrexate and higher DAS28-CRP than high-risk/low-benefit patients at baseline. <b>Conclusion:</b> ABA was well tolerated and similarly efficacious in the EG and NEG. Identification of factors related to low-risk/high-benefit may aid appropriate patient selection.
DOI: 10.7284/130377
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SKQ201806S using a Hawaii UHDAS instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7252166.v1
title: Safety and effectiveness of abatacept in Japanese non-elderly and elderly patients with rheumatoid arthritis in an all-cases post-marketing surveillance

description: <b>Objectives:</b> To investigate the safety, effectiveness, and risk-benefit balance of intravenous abatacept (ABA) in non-elderly (&lt;65 years: NEG) and elderly (≥65 years: EG) rheumatoid arthritis patients. <b>Methods:</b> This sub-analysis of an all-cases postmarketing surveillance in Japan assessed safety in all enrolled patients and effectiveness in those with Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) measurements at ≥2 time points including baseline. Risk-benefit was evaluated based on infections and DAS28-CRP improvement &gt;1.2. <b>Results:</b> The NEG and EG of the safety analysis set comprised 2,170 and 1,712 patients, respectively; corresponding 6-month ABA retention rates were 80.2% and 77.1%. The NEG had fewer adverse drug reactions (14.5% vs. 17.2%, <i>p</i> = .021) and infections (4.8% vs. 7.2%, <i>p</i> = .002) than the EG. DAS28-CRP changed similarly between groups. The proportion of patients with low-risk/high-benefit and high-risk/low-benefit were 33.1% and 6.9% (NEG) and 29.7% and 9.0% (EG). Low-risk/high-benefit patients were younger, had shorter disease duration and fewer comorbidities, and were with less use of oral glucocorticoid and prior biologics, more use of methotrexate and higher DAS28-CRP than high-risk/low-benefit patients at baseline. <b>Conclusion:</b> ABA was well tolerated and similarly efficacious in the EG and NEG. Identification of factors related to low-risk/high-benefit may aid appropriate patient selection.
DOI: 10.6084/m9.figshare.7252142
title: List of analysed projects

description: list of top 100 popular GitHub projects, as used for the EMSE2018 data set
DOI: 10.7284/130375
title: Anemometer data collected during research cruise SKQ201806S using a Gill WindObserver 75 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7252139
title: StopWords

description: list of keywords used in the stemming of concepts within a Java class
DOI: 10.6084/m9.figshare.7252142.v1
title: List of analysed projects

description: list of top 100 popular GitHub projects, as used for the EMSE2018 data set
DOI: 10.6084/m9.figshare.7252121
title: olivine_contig-65.fa

description: Metagenome from an olivine biofilm obtained from a 4 year colonization experiment in IODP Hole 1301A on the Juan de Fuca Ridge.
DOI: 10.6084/m9.figshare.7252139.v1
title: StopWords

description: list of keywords used in the stemming of concepts within a Java class
DOI: 10.7284/130376
title: Anemometer data collected during research cruise SKQ201806S using a Gill WindObserver 75 instrument system onboard the platform RV Sikuliaq

description: Processed data created by vessel technician during a Field_expedition
DOI: 10.6084/m9.figshare.7252118
title: Supplementary Material for: Diet and Psychosis: A Scoping Review

description: <b><i>Introduction:</i></b> Schizophrenia spectrum disorders (SSD) represent a cluster of severe mental illnesses. Diet has been identified as a modifiable risk factor and opportunity for intervention in many physical illnesses and more recently in mental illnesses such as unipolar depression; however, no dietary guidelines exist for patients with SSD. <b><i>Objective:</i></b> This review sought to systematically scope the existing literature in order to identify nutritional interventions for the prevention or treatment of mental health symptoms in SSD as well as gaps and opportunities for further research. <b><i>Methods:</i></b> This review followed established methodological approaches for scoping reviews including an extensive a priori search strategy and duplicate screening. Because of the large volume of results, an online program (Abstrackr) was used for screening and tagging. Data were extracted based on the dietary constituents and analyzed. <b><i>Results:</i></b> Of 55,330 results identified by the search, 822 studies met the criteria for inclusion. Observational evidence shows a connection between the presence of psychotic disorders and poorer quality dietary patterns, higher intake of refined carbohydrates and total fat, and lower intake or levels of fibre, ω-3 and ω-6 fatty acids, vegetables, fruit, and certain vitamins and minerals (vitamin B<sub>12</sub> and B<sub>6</sub>, folate, vitamin C, zinc, and selenium). Evidence illustrates a role of food allergy and sensitivity as well as microbiome composition and specific phytonutrients (such as L-theanine, sulforaphane, and resveratrol). Experimental studies have demonstrated benefit using healthy diet patterns and specific vitamins and minerals (vitamin B<sub>12</sub> and B<sub>6</sub>, folate, and zinc) and amino acids (serine, lysine, glycine, and tryptophan). <b><i>Discussion:</i></b> Overall, these findings were consistent with many other bodies of knowledge about healthy dietary patterns. Many limitations exist related to the design of the individual studies and the ability to extrapolate the results of studies using dietary supplements to dietary interventions (food). Dietary recommendations are presented as well as recommendations for further research including more prospective observational studies and intervention studies that modify diet constituents or entire dietary patterns with statistical power to detect mental health outcomes.
DOI: 10.6084/m9.figshare.7252121.v2
title: olivine_contig-65.fa

description: Metagenome from an olivine biofilm obtained from a 4 year colonization experiment in IODP Hole 1301A on the Juan de Fuca Ridge.
DOI: 10.7284/130360
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SKQ201806S using a Sea-Bird SBE-911+ instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7252121.v1
title: olivine_contig-65.fa

description: Metagenome from an olivine biofilm obtained from a 4 year colonization experiment in IODP Hole 1301A on the Juan de Fuca Ridge.
DOI: 10.7284/130362
title: Flowmeter data collected during research cruise SKQ201806S using a Omega FP-2541 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130363
title: Flowmeter data collected during research cruise SKQ201806S using a Krohne Optiflux 5000 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130365
title: Fluorometer data collected during research cruise SKQ201806S using a Turner Cyclops-7 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7251950
title: varDB_data.tar.gz

description: VarDB hg19 data files<br>
DOI: 10.7284/130366
title: GNSS (Global Navigation Satellite System) data collected during research cruise SKQ201806S using a C&C C-Nav 3050 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7251950.v1
title: varDB_data.tar.gz

description: VarDB hg19 data files<br>
DOI: 10.7284/130361
title: Gravimeter data collected during research cruise SKQ201806S using a Bell BGM-3 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7251926
title: Supplementary Material for: Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments

description: <b><i>Background/Aims:</i></b> Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence and underlying mechanisms remain unknown. <b><i>Methods:</i></b> Adolescent male Wistar rats (post-natal day 27) were exposed to inhaled toluene (10,000 ppm) (<i>n</i> = 32) or air (<i>n</i> = 48) for 1 h/day, 3 days/week for 4 weeks, followed by 4 weeks of abstinence. Twenty air rats were pair-fed to the toluene group, to differentiate the direct effects of toluene from under-nutrition. Food intake, weight, and growth were monitored. Metabolic hormones were measured after exposure and abstinence periods. Energy expenditure was measured using indirect calorimetry. Adrenal function was assessed using adrenal histology and hormone testing. <b><i>Results:</i></b> Inhalant abuse suppressed appetite and increased energy expenditure. Reduced weight gain and growth were observed in both the toluene and pair-fed groups. Compared to the pair-fed group, and despite normalisation of food intake, the suppression of weight and growth for toluene-exposed rats persisted during abstinence. After exposure, toluene-exposed rats had low fasting blood glucose and insulin compared to the air and pair-fed groups. Consistent with adrenal insufficiency, adrenal hypertrophy and increased basal adrenocorticotropic hormone were observed in the toluene-exposed rats, despite normal basal corticosterone levels. <b><i>Conclusions:</i></b> Inhalant abuse results in negative energy balance, persistent growth impairment, and endocrine changes suggestive of adrenal insufficiency. We conclude that adrenal insufficiency contributes to the negative energy balance phenotype, potentially presenting a significant additional health risk for inhalant users.
DOI: 10.7284/130367
title: Gyrocompass data collected during research cruise SKQ201806S using a Sperry NAVIGAT 2100 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130368
title: Gyrocompass data collected during research cruise SKQ201806S using a Sperry NAVIGAT 2100 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130378
title: INS (Inertial Navigation System) data collected during research cruise SKQ201806S using a Kongsberg Seapath 320+ instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/130369
title: Meteorological Station data collected during research cruise SKQ201806S using a Vaisala WXT520 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.25377/sussex.7251845
title: Letter from Jacob Spafford, 15/10/1927

description: This is a digital reproduction of a handwritten letter from Jacob Spafford (to Mr Peters?), dated 15 October, 1927. Jacob Spafford was the adopted son of Horatio and Anna Spafford, two of the founding members of the American Colony in Jerusalem.<br>Mentions the earthquake but also “good news” that the road from Damascus Gate to their house has been paved, as have roads to Jaffa, Bethlehem and Ramallah. <br><br>The letter was digitised by the Planet Bethlehem Archive and exists as part of the 1927 Earthquake collection within the Library of Congress project of the Planet Bethlehem Archive.
DOI: 10.25377/sussex.7251842
title: Letter from Jacob Spafford, 02/08/1927

description: This is a digital reproduction of a letter held in the Library of Congress from Jacob Spafford to a "dear friend”, dated 2 Aug., 1927. Jacob Spafford was the adopted son of Horatio and Anna Spafford, two of the founding members of the American Colony in Jerusalem.<br><br>Describes the devastating effects of the earthquake. Included is a description of an encounter with a man from Bethlehem who says no one was killed there but the damage suffered would require £100,000 to rectify (p.2). Also describes damage and loss of life in Nablus (70 dead), Ramleh, Ludd and Rama – the worst effected towns - as well as the kindness of people helping each other out, including Bedouins. Says Jerusalem got off relatively lightly although damage was worse on Mount of Olives. <br><br>This image was digitised by the Planet Bethlehem Archive and exists as part of the 1927 Earthquake collection within the Library of Congress project of the Planet Bethlehem Archive.
DOI: 10.25377/sussex.7251845.v1
title: Letter from Jacob Spafford, 15/10/1927

description: This is a digital reproduction of a handwritten letter from Jacob Spafford (to Mr Peters?), dated 15 October, 1927. Jacob Spafford was the adopted son of Horatio and Anna Spafford, two of the founding members of the American Colony in Jerusalem.<br>Mentions the earthquake but also “good news” that the road from Damascus Gate to their house has been paved, as have roads to Jaffa, Bethlehem and Ramallah. <br><br>The letter was digitised by the Planet Bethlehem Archive and exists as part of the 1927 Earthquake collection within the Library of Congress project of the Planet Bethlehem Archive.
DOI: 10.7284/130370
title: Radiometer data collected during research cruise SKQ201806S using a RMR Co. PRP instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.25377/sussex.7251842.v1
title: Letter from Jacob Spafford, 02/08/1927

description: This is a digital reproduction of a letter held in the Library of Congress from Jacob Spafford to a "dear friend”, dated 2 Aug., 1927. Jacob Spafford was the adopted son of Horatio and Anna Spafford, two of the founding members of the American Colony in Jerusalem.<br><br>Describes the devastating effects of the earthquake. Included is a description of an encounter with a man from Bethlehem who says no one was killed there but the damage suffered would require £100,000 to rectify (p.2). Also describes damage and loss of life in Nablus (70 dead), Ramleh, Ludd and Rama – the worst effected towns - as well as the kindness of people helping each other out, including Bedouins. Says Jerusalem got off relatively lightly although damage was worse on Mount of Olives. <br><br>This image was digitised by the Planet Bethlehem Archive and exists as part of the 1927 Earthquake collection within the Library of Congress project of the Planet Bethlehem Archive.
DOI: 10.7284/130371
title: Radiometer data collected during research cruise SKQ201806S using a Biospherical QSR-2150 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7251803
title: SKA_Lees_trees.tgz

description: SKA and kSNP3 trees created from the data of Lees et al. 2018.
DOI: 10.6084/m9.figshare.7251785
title: Comparison of Feature Vector Compositions to Enhance the Performance of NIRS-BCI-triggered Robotic Hand Orthosis for Post-stroke Motor Recovery

description: [Motor execution data set for NIRS-BCI]<br>Subjects: seven neurologically intact partipants. (all right-handed)<br>Task: closing and opening a hand.<br>Experimental design: 1. one resting period (60 s) + 15 repeated unit trials (50 s). 2. a unit trial: ready (5 s) + hand-closing (15 s) + hand-opening (30 s). 3. total: 810 s. NIRS system: Shimadzu LABNIRS system.<br> 1. total nine channels on C3 (10-20 system)<br>Please see 'Data Description.pdf' for details.<br>
DOI: 10.6084/m9.figshare.7251803.v1
title: SKA_Lees_trees.tgz

description: SKA and kSNP3 trees created from the data of Lees et al. 2018.
DOI: 10.7284/130364
title: Rain Gauge data collected during research cruise SKQ201806S using a RM Young 50202 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7251704
title: JCEM-jc-2018-01974-KAHALY-SUPPLEMENTAL-TABLES.pdf

description: <b>Context</b>: The Major Histocompatibility Complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA). <b>Objective</b>: To evaluate the impact of gender on human leukocyte antigen (HLA) association with PGA for the first time. <b>Design</b>: Cross-sectional immunogenetic study <b>Setting</b>: Academic, tertiary referral, orphan disease center for PGA (ORPHA 282196) and immunogenetics laboratory <b>Subjects</b>: 158 patients with coexistent type 1 diabetes and autoimmune thyroid disease (adult type three PGA, ORPHA 227982) and 479 unrelated healthy controls <b>Methods: </b>All 637 subjects were typed for HLA-A, -B, DRB1, -DQA1, and –DQB1 alleles at a two-field level.<b> </b> <b>Main outcome measure</b>: Modification of the gene-disease association by gender <b>Results</b>: MHC class I <i>HLA-A</i> association was gender-related to both the total adult type three PGA collective (n=158, <i>p</i>=0.0065) as well as in PGA patients with autoimmune Hashimoto’s thyroiditis (n=91, <i>p</i>=0.010). Compared to HLA-A*02:01, <i>A*11:01</i> was overrepresented in male patients, yet underrepresented in females (OR 1.49, 95% CI 0.55-3.88 vs. 0.42, 0.12-1.17). A<i>*24:02</i> was underrepresented in males but not in female patients (OR 0.37, 95% CI 0.111.04 vs. 1.19, 0.65-2.15). Excluding the five most frequent alleles (A*01:01, A*02:01, A*03:01, A*11:01, and A*24:02), the sum of all other identified alleles was underrepresented in male patients (OR 0.37, 0.18-0.72, <i>p</i>=0.0046). The strong MHC HLA-B association with PGA (<i>p</i>&lt;0.0001) was not gender-related (<i>p</i>=0.55). Further, no interaction with gender was observed for the MHC class II <i>HLA-DRB1</i>, <i>DQA1,</i> and <i>DQB1</i> alleles. <b>Conclusion</b>: MHC class I<i> HLA-A </i>association with type three PGA is significantly affected by gender.
DOI: 10.6084/m9.figshare.7251785.v2
title: Comparison of Feature Vector Compositions to Enhance the Performance of NIRS-BCI-triggered Robotic Hand Orthosis for Post-stroke Motor Recovery

description: [Motor execution data set for NIRS-BCI]<br>Subjects: seven neurologically intact partipants. (all right-handed)<br>Task: closing and opening a hand.<br>Experimental design: 1. one resting period (60 s) + 15 repeated unit trials (50 s). 2. a unit trial: ready (5 s) + hand-closing (15 s) + hand-opening (30 s). 3. total: 810 s. NIRS system: Shimadzu LABNIRS system.<br> 1. total nine channels on C3 (10-20 system)<br>Please see 'Data Description.pdf' for details.<br>