cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6448544
title: ANTIMICROBIAL BIODEGRADABLE POLYMER THROUGH ADDITIVATION WITH ZINC BASED COMPOUNDS

description: Antimicrobial packaging is a promising type of active packaging, which has an antimicrobial agent incorporated into the polymer matrix, capable to eliminate or inhibit deteriorating and/or pathogenic microorganisms. The zinc compounds are antimicrobial agents commonly used to confer this feature. The objective of this work was to evaluate the antimicrobial activity of biodegradable Ecoflex® films with 1% and 2% (w/w) zinc oxide nanoparticles (ZnO NPs) and 1% and 2% (w/w) glass microparticles doped with ionic zinc (Zn MCs), against Staphylococcus aureus and Escherichia coli. The sample’s biodegradation in soil also were studied. Microbiological results showed that biodegradable polymeric films obtained were effective to inhibit and/or kill S. aureus and E. coli at the initial concentration of 104 CFU.mL-1 after 24 h of contact. When evaluated the biodegradation of the polymers containing the additives, the results showed that the addition of zinc compounds to the biodegradable polymer did not affect its biodegradability characteristic. The antimicrobial biodegradable films developed have potential application to the food packaging industry.
DOI: 10.6084/m9.figshare.6448544.v1
title: ANTIMICROBIAL BIODEGRADABLE POLYMER THROUGH ADDITIVATION WITH ZINC BASED COMPOUNDS

description: Antimicrobial packaging is a promising type of active packaging, which has an antimicrobial agent incorporated into the polymer matrix, capable to eliminate or inhibit deteriorating and/or pathogenic microorganisms. The zinc compounds are antimicrobial agents commonly used to confer this feature. The objective of this work was to evaluate the antimicrobial activity of biodegradable Ecoflex® films with 1% and 2% (w/w) zinc oxide nanoparticles (ZnO NPs) and 1% and 2% (w/w) glass microparticles doped with ionic zinc (Zn MCs), against Staphylococcus aureus and Escherichia coli. The sample’s biodegradation in soil also were studied. Microbiological results showed that biodegradable polymeric films obtained were effective to inhibit and/or kill S. aureus and E. coli at the initial concentration of 104 CFU.mL-1 after 24 h of contact. When evaluated the biodegradation of the polymers containing the additives, the results showed that the addition of zinc compounds to the biodegradable polymer did not affect its biodegradability characteristic. The antimicrobial biodegradable films developed have potential application to the food packaging industry.
DOI: 10.6084/m9.figshare.6448535
title: CHROMATOGRAPHIC INVESTIGATION OF RUTHENIUM NITROSYL COMPLEX: NO INTERCONVERSION AND REACTIONS WITH BIOLOGICAL REDUCTANTS

description: One experimental strategy to prepare a nitrosyl metal complex is based on the acid-base conversion of NO2- into NO+. Here, we employed UV-vis absorption and FTIR spectroscopies to investigate the reaction of cis-[Ru(NO2)(bpy)2(imN)]PF6 with H3O+, which produced cis-[Ru(NO)(bpy)2(imN)](PF6)3 complex. Chromatographic studies were carried out and showed that immediately after nitrite complex was dissolved only one species was present with retention time(tR) of 6.81 minutes. Addition of H3O+ to nitrite complex led to the formation of one major peak with tR of 3.92 min supporting nitrosyl complex formation. The reaction of nitrosyl complex with cysteine was also monitored by HPLC and it showed clearly the formation and followed decrease of a peak at 3.38 minute with maximum absorption at 380 nm, consistent with an intermediate complex. Later, it was observed the appearance of a peak at 4.15 minute with absorption band at 470 nm. In contrast to the reaction with cysteine, methionine did not show the formation of any intermediate. The use of HPLC was an important tool to support mechanistic assumptions for nitrosyl reactions.
DOI: 10.6084/m9.figshare.6448535.v1
title: CHROMATOGRAPHIC INVESTIGATION OF RUTHENIUM NITROSYL COMPLEX: NO INTERCONVERSION AND REACTIONS WITH BIOLOGICAL REDUCTANTS

description: One experimental strategy to prepare a nitrosyl metal complex is based on the acid-base conversion of NO2- into NO+. Here, we employed UV-vis absorption and FTIR spectroscopies to investigate the reaction of cis-[Ru(NO2)(bpy)2(imN)]PF6 with H3O+, which produced cis-[Ru(NO)(bpy)2(imN)](PF6)3 complex. Chromatographic studies were carried out and showed that immediately after nitrite complex was dissolved only one species was present with retention time(tR) of 6.81 minutes. Addition of H3O+ to nitrite complex led to the formation of one major peak with tR of 3.92 min supporting nitrosyl complex formation. The reaction of nitrosyl complex with cysteine was also monitored by HPLC and it showed clearly the formation and followed decrease of a peak at 3.38 minute with maximum absorption at 380 nm, consistent with an intermediate complex. Later, it was observed the appearance of a peak at 4.15 minute with absorption band at 470 nm. In contrast to the reaction with cysteine, methionine did not show the formation of any intermediate. The use of HPLC was an important tool to support mechanistic assumptions for nitrosyl reactions.
DOI: 10.6084/m9.figshare.6448529
title: PHENOLIC DERIVATIVES AND ANTIOXIDANT ACTIVITY OF POLAR EXTRACTS FROM Bauhinia pulchella

description: A tea made with the leaves or stem bark of Bauhinia pulchella Benth (Fabaceae) is used in the treatment of diabetes. Ethanol (EEF) and aqueous (EAF) extracts were obtained from the leaves and the antioxidant and citotoxic activities were tested, as well as quantify the content of flavonoids and phenolic compounds (TPC). EEF and EAF showed similar profiles by HPLC, with the presence of three compounds. Column chromatography reverse phase (C18) and Sephadex LH-20, followed by semi preparative HPLC-C18 of EAF resulted in three flavonoids. Their structures were identified by 1H and 13C NMR as myricitrin (1), quercitrin (2) and afzelin (3). In assay of determination of reactive substances to thiobarbituric acid (TBARS), with DPPH, ABTS and nitric oxide (NO•) free radicals, EAF showed antioxidant potential higher than the EEF. This is the first report of the occurrence of the flavonoids 1-3, in the species B. pulchella. EEF and EAF were inactive in the cytotoxicity assays. In short, the polar extracts from the leaves of B. pulchella proved to be promising sources of biomolecules phenolic, with antioxidant potential, which may, in the future, be used as chemical markers for species and validation of therapeutic use.
DOI: 10.6084/m9.figshare.6448529.v1
title: PHENOLIC DERIVATIVES AND ANTIOXIDANT ACTIVITY OF POLAR EXTRACTS FROM Bauhinia pulchella

description: A tea made with the leaves or stem bark of Bauhinia pulchella Benth (Fabaceae) is used in the treatment of diabetes. Ethanol (EEF) and aqueous (EAF) extracts were obtained from the leaves and the antioxidant and citotoxic activities were tested, as well as quantify the content of flavonoids and phenolic compounds (TPC). EEF and EAF showed similar profiles by HPLC, with the presence of three compounds. Column chromatography reverse phase (C18) and Sephadex LH-20, followed by semi preparative HPLC-C18 of EAF resulted in three flavonoids. Their structures were identified by 1H and 13C NMR as myricitrin (1), quercitrin (2) and afzelin (3). In assay of determination of reactive substances to thiobarbituric acid (TBARS), with DPPH, ABTS and nitric oxide (NO•) free radicals, EAF showed antioxidant potential higher than the EEF. This is the first report of the occurrence of the flavonoids 1-3, in the species B. pulchella. EEF and EAF were inactive in the cytotoxicity assays. In short, the polar extracts from the leaves of B. pulchella proved to be promising sources of biomolecules phenolic, with antioxidant potential, which may, in the future, be used as chemical markers for species and validation of therapeutic use.
DOI: 10.6084/m9.figshare.6448526
title: Modified Pereira Suture as an Effective Option to Treat Postpartum Hemorrhage due to Uterine Atony

description: Abstract Nowadays, postpartum hemorrhage is the major cause of maternal mortality and morbidity worldwide. Uterine atony is its main cause; thus, prophylactic measures, as well as medical and surgical fast approaches, have been developed to manage it. The uterine compression sutures are a possible treatment that preserves the uterus and, consequently, the fertility potential. Bearing that in mind, we report two cases of postpartum hemorrhage after caesarean section, successfully treated with a new modification of Pereira suture - longitudinal and transverse uterine sutures were applied after no response was registered to the first-line therapies. Both women recovered, and the postpartum evaluation revealed a normal uterus with an adequate blood supply, suggesting potential fertility, as described in the literature regarding this kind of therapeutic approach.
DOI: 10.6084/m9.figshare.6448526.v1
title: Modified Pereira Suture as an Effective Option to Treat Postpartum Hemorrhage due to Uterine Atony

description: Abstract Nowadays, postpartum hemorrhage is the major cause of maternal mortality and morbidity worldwide. Uterine atony is its main cause; thus, prophylactic measures, as well as medical and surgical fast approaches, have been developed to manage it. The uterine compression sutures are a possible treatment that preserves the uterus and, consequently, the fertility potential. Bearing that in mind, we report two cases of postpartum hemorrhage after caesarean section, successfully treated with a new modification of Pereira suture - longitudinal and transverse uterine sutures were applied after no response was registered to the first-line therapies. Both women recovered, and the postpartum evaluation revealed a normal uterus with an adequate blood supply, suggesting potential fertility, as described in the literature regarding this kind of therapeutic approach.
DOI: 10.6084/m9.figshare.6448523
title: Systematic Review of Oral Therapy for the Treatment of Symptoms of Bladder PainSyndrome: The Brazilian Guidelines

description: Abstract Interstitial cystitis (IC), including bladder pain syndrome (BPS), is a chronic and debilitating disease thatmainly affectswomen. It is characterized by pelvic pain associated with urinary urgency, frequency, nocturia and negative urine culture,with normal cytology. In 2009, the Society for Urodynamics and Female Urology (SUFU) defined the term IC/BPS as an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes. This is the definition used by the American Urological Association (AUA) in the most recent guidelines on IC/BPS. Interstitial cystitis may be sufficiently severe to have a devastating effect on the quality of life, but it may also be associated with moderate symptoms whose effects are less debilitating. Although there are several clinical trials to assess oral and intravesical therapies, the treatment for IC remains far from ideal. This systematic assessment evaluates published randomized clinical trials on oralmedications used totreat symptoms of BPS. This studywas performed according to the preferred reporting items for systematic reviews and metaanalyses (PRISMA)method. Two independent reviewers screened the studies to determine their inclusion or exclusion and to perform the methodological analysis. The inclusion criteria included randomized studiespublishedbetween April of 1988and April of2016 that used oral medications to treat symptoms of BPS or IC. According to the systematic review performed,we should consider pentosan polysulfate as one of the bestoptions of oral drugs for the treatment of BPS symptoms. However, this drug is not an available option in Brazil. Orally administered amitriptyline is an efficacious medical treatment for BPS, and it should be the first treatment offered.
DOI: 10.6084/m9.figshare.6448523.v1
title: Systematic Review of Oral Therapy for the Treatment of Symptoms of Bladder PainSyndrome: The Brazilian Guidelines

description: Abstract Interstitial cystitis (IC), including bladder pain syndrome (BPS), is a chronic and debilitating disease thatmainly affectswomen. It is characterized by pelvic pain associated with urinary urgency, frequency, nocturia and negative urine culture,with normal cytology. In 2009, the Society for Urodynamics and Female Urology (SUFU) defined the term IC/BPS as an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes. This is the definition used by the American Urological Association (AUA) in the most recent guidelines on IC/BPS. Interstitial cystitis may be sufficiently severe to have a devastating effect on the quality of life, but it may also be associated with moderate symptoms whose effects are less debilitating. Although there are several clinical trials to assess oral and intravesical therapies, the treatment for IC remains far from ideal. This systematic assessment evaluates published randomized clinical trials on oralmedications used totreat symptoms of BPS. This studywas performed according to the preferred reporting items for systematic reviews and metaanalyses (PRISMA)method. Two independent reviewers screened the studies to determine their inclusion or exclusion and to perform the methodological analysis. The inclusion criteria included randomized studiespublishedbetween April of 1988and April of2016 that used oral medications to treat symptoms of BPS or IC. According to the systematic review performed,we should consider pentosan polysulfate as one of the bestoptions of oral drugs for the treatment of BPS symptoms. However, this drug is not an available option in Brazil. Orally administered amitriptyline is an efficacious medical treatment for BPS, and it should be the first treatment offered.
DOI: 10.6084/m9.figshare.6448517
title: DETERMINATION OF SODIUM IN CACHAÇA BY ATOMIC EMISSION SPECTROMETRY: EFFECT OF THE PHYSICOCHEMICAL PROPERTIES OF THE SOLUTION

description: The use of samples from students quotidian can get their attention for teaching contents to be presented. We have already presented a series of simple experiments demonstrating the use of flame atomic emission spectrometry in the determination of cations in samples present in our day life. Here sodium is determined in cachaça (sugar cane spirit), a very popular Brazilian drink, to demonstrate de effect of matrix composition and its physico-chemical properties in the volume of sample nebulized in a flame photometer and consequently in analytical signals by using different ethanol:water solvent mixtures for calibration.
DOI: 10.6084/m9.figshare.6448517.v1
title: DETERMINATION OF SODIUM IN CACHAÇA BY ATOMIC EMISSION SPECTROMETRY: EFFECT OF THE PHYSICOCHEMICAL PROPERTIES OF THE SOLUTION

description: The use of samples from students quotidian can get their attention for teaching contents to be presented. We have already presented a series of simple experiments demonstrating the use of flame atomic emission spectrometry in the determination of cations in samples present in our day life. Here sodium is determined in cachaça (sugar cane spirit), a very popular Brazilian drink, to demonstrate de effect of matrix composition and its physico-chemical properties in the volume of sample nebulized in a flame photometer and consequently in analytical signals by using different ethanol:water solvent mixtures for calibration.
DOI: 10.6084/m9.figshare.6448511
title: MEDICINAL CHEMISTRY PERSPECTIVES FOR THE 21ST CENTURY: CHALLENGES AND OPPROTUNITIES

description: In the 21st century, medicinal chemists will face many challenges to improve the quality of life of populations. The challenges consist of emerging infectious (ex. bacterial, viral and parasite infections) and non-communicable diseases (ex. autoimmune, Alzheimer disease, Parkinson’s disease) that will require innovative technologies (ex. microfluidics, nanotechnology, biotechnology) to be fully understood and combated. In this work, we indicate trends, perspectives and opportunities related to drug discovery as well as highlight the tools and strategies that could be used in drug discovery of the 21st century.
DOI: 10.6084/m9.figshare.6448508
title: Teresina’s planning and municipal budget for economic growth and environment during 2014 to 2016

description: Abstract The construction of sustainable cities starts from the perspective of compatibility between economic growth and ecological caution. In this context, the present study analyzed the incorporation of this paradigm to the Teresina’s urban planning instruments. In order to do so, we selected the guidelines of the city master plan that act directly on economic growth and the environment, and examined the provision and budget execution for these standards in 2014, 2015 and 2016. The results revealed a municipality that promoted productive activities with steps that diminish the stress on the environment, by providing a master plan with criteria for solid waste management, environmental zoning, green areas, urban drainage, clean rivers and sanitary sewage. We noticed the alignment between the instruments investigated also identified the provision of resources for environmental management, basic sanitation, urban public cleaning and waste collection services, as well as for the promotion of productive sectors. But in examining the financial execution, we verified that less than 50% of the budget foreseen for these areas was executed, with the municipality concentrating budget execution in areas such as social security, special expenses and health. We concluded that Teresina incorporated the principles of sustainable city in the urban planning instruments analyzed, but in the years 2014 to 2016 did not prioritize these areas with financial resources.
DOI: 10.6084/m9.figshare.6448511.v1
title: MEDICINAL CHEMISTRY PERSPECTIVES FOR THE 21ST CENTURY: CHALLENGES AND OPPROTUNITIES

description: In the 21st century, medicinal chemists will face many challenges to improve the quality of life of populations. The challenges consist of emerging infectious (ex. bacterial, viral and parasite infections) and non-communicable diseases (ex. autoimmune, Alzheimer disease, Parkinson’s disease) that will require innovative technologies (ex. microfluidics, nanotechnology, biotechnology) to be fully understood and combated. In this work, we indicate trends, perspectives and opportunities related to drug discovery as well as highlight the tools and strategies that could be used in drug discovery of the 21st century.
DOI: 10.6084/m9.figshare.6448508.v1
title: Teresina’s planning and municipal budget for economic growth and environment during 2014 to 2016

description: Abstract The construction of sustainable cities starts from the perspective of compatibility between economic growth and ecological caution. In this context, the present study analyzed the incorporation of this paradigm to the Teresina’s urban planning instruments. In order to do so, we selected the guidelines of the city master plan that act directly on economic growth and the environment, and examined the provision and budget execution for these standards in 2014, 2015 and 2016. The results revealed a municipality that promoted productive activities with steps that diminish the stress on the environment, by providing a master plan with criteria for solid waste management, environmental zoning, green areas, urban drainage, clean rivers and sanitary sewage. We noticed the alignment between the instruments investigated also identified the provision of resources for environmental management, basic sanitation, urban public cleaning and waste collection services, as well as for the promotion of productive sectors. But in examining the financial execution, we verified that less than 50% of the budget foreseen for these areas was executed, with the municipality concentrating budget execution in areas such as social security, special expenses and health. We concluded that Teresina incorporated the principles of sustainable city in the urban planning instruments analyzed, but in the years 2014 to 2016 did not prioritize these areas with financial resources.
DOI: 10.6084/m9.figshare.6448490
title: Recent Advances and Perspectives in Cancer Drug Design

description: ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and antibody-small molecule conjugates have emerged as a worthwhile approach to improve drug selectivity and reduce adverse effects, which are the main challenges in cancer drug discovery. This review will examine the current panorama of drug research and development (R&D) with emphasis on some of the major advances brought to clinical trials and to the market in the past five years. Breakthrough discoveries will be highlighted along with the medicinal chemistry strategies used throughout the discovery process. In addition, this review will provide perspectives and updates on the discovery of novel molecular targets as well as drugs with innovative mechanisms of action.
DOI: 10.6084/m9.figshare.6448490.v1
title: Recent Advances and Perspectives in Cancer Drug Design

description: ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and antibody-small molecule conjugates have emerged as a worthwhile approach to improve drug selectivity and reduce adverse effects, which are the main challenges in cancer drug discovery. This review will examine the current panorama of drug research and development (R&D) with emphasis on some of the major advances brought to clinical trials and to the market in the past five years. Breakthrough discoveries will be highlighted along with the medicinal chemistry strategies used throughout the discovery process. In addition, this review will provide perspectives and updates on the discovery of novel molecular targets as well as drugs with innovative mechanisms of action.