cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9986006.v1
title: Diagnosis of brain death in Brazil

description: ABSTRACT Brain death, defined as the complete and irreversible loss of brain functions, has a history that is linked to the emergence of intensive care units and the advancement of artificial ventilatory support. In Brazil, by federal law, the criteria for the diagnosis of brain death have been defined by the Federal Council of Medicine since 1997 and apply to the entire Brazilian territory. Resolution 2,173/2017 of the Federal Council of Medicine updated the criteria for diagnosing brain death. These changes include the following: the requirement for the patient to meet specific physiological prerequisites and for the physician to provide optimized care to the patient before starting the procedures for diagnosing brain death and to perform complementary tests, as well as the need for specific training for physicians who make this diagnosis. Other changes include the reduction of the time interval between the two clinical examinations, the possibility of continuing procedures in the presence of unilateral ear or eye injury, the performance of a single apnea test and the creation of a statement of brain death determination that includes the recording of all procedures in a single document. This document, despite the controversy surrounding it, increases the safety necessary when establishing a diagnosis of such importance and has positive implications that extend beyond the patient and the physician to reach the entire health system.
DOI: 10.6084/m9.figshare.9985997
title: CASE SERIES OF PATIENTS UNDER BIWEEKLY TREATMENT WITH LARONIDASE: A REPORT OF A SINGLE CENTER EXPERIENCE

description: ABSTRACT Objective: To report the stabilization of urinary glycosaminoglicans (GAG) excretion and clinical improvements in patients with mucopolysaccharidosis type I (MPS I) under an alternative dose regimen of laronidase of 1.2 mg/kg every other week. Methods: We participated in a dose-optimization trial for laronidase in MPS-I patients using four alternative regimens: 0.58 mg/kg every week, 1.2 mg/kg every two weeks, 1.2 mg/kg every week and 1.8 mg/kg every other week (EOW). After the trial ended, the patients resumed the recommended dose and regimen of 0.58 mg/kg every week. Under this regimen, some patients presented difficulties in venous access and were unable to commute weekly to the treatment center. Therefore, we used an alternative regimen that consisted of 1.2 mg/kg EOW in eight patients. A retrospective study of medical records of MPS-I patients who underwent both enzyme replacement therapy (ERT) regimens, of 0.58 mg/kg every week and 1.2 mg/kg EOW, was done. Results: Patients remained clinically stable under the alternative regimen, did not present elevation of urinary GAG nor any adverse event. Conclusions: The switch of dose regimen to 1.2 mg/kg EOW of laronidase was safe, and did not cause any clinical worsening in patients who had been previously under standard dose ERT.
DOI: 10.6084/m9.figshare.9986003.v1
title: Foliar application of silicon decreases wheat blast symptoms without impairing photosynthesis

description: ABSTRACT Considering the importance of blast, caused by Pyricularia oryzae, to impact wheat yield, this study investigated whether the foliar spray of potassium silicate (PS) could affect the photosynthesis of wheat plants and its potential to reduce disease symptoms. The Exp. 1 aimed to determine the effect of the foliar spray of PS on the photosynthetic performance of plants and was arranged in a completely randomized design with six treatments (plants sprayed with PS rates of 2.5, 5.0, 7.5, 10.0, and 12.5 g·L-1 at 35 days after emergence) and six replications. The leaf gas exchange (net CO2 assimilation rate (A), internal CO2 concentration (Ci), stomatal conductance to water vapor (gs), and transpiration rate (E)) as well as fluorescence of chlorophyll a (maximal photosystem II quantum yield (Fv/Fm), quantum yield of non-regulated energy dissipation [Y(NO)], photochemical yield [Y(II)], electron transport rate (ETR), and quenching non-photochemical [Y(NPQ)]) parameters were evaluated. The Exp. 2 was carried out to determine the effect of PS on blast control and also on the photosynthetic performance of plants. Plants at 35 days after emergence were sprayed with PS rate of 12.5 g·L-1, which did not affect photosynthesis on plants from Exp.1. This experiment was a 2 × 4 factorial and arranged in a completely randomized design with six replications. The factors studied were plants non-inoculated or inoculated plants and the spray of water, PS, fungicide (trifloxystrobin 10% + tebuconazole 20%; 0.75 L/ha), and fungicide + PS. There were no significant changes in the values of A, gs, E, Ci, Fv/Fm, Y(NO), Y(II), Y(NPQ), and ETR for plants sprayed three times (every 96 h interval) as the PS rates increased from 2.5 to 12.5 g·L-1. There was no significant relationship between the PS rates with either absorbance, reflectance or transmittance on the leaf blades. Linear regression model best described the foliar Si concentration-PS rates relationship. Foliar Si concentration significantly increased by 44 and 42%, respectively, for the PS and PS + fungicide treatments compared to water-sprayed plants. The area under disease progress curve was significantly lower by 64, 58, and 53%, respectively, for the fungicide, PS, and fungicide + PS treatments in comparison to water-sprayed plants. The photosynthetical process, primarily related to the Fv/Fm parameter, on wheat leaves was greatly impaired during the infection process of P. oryzae, but to a lesser extent on the leaves of PS-sprayed plants. In conclusion, the foliar spray of PS can be an environmentally friendly strategy to control wheat blast without causing perturbation to the photosynthetic machinery of wheat plants.
DOI: 10.6084/m9.figshare.9985994.v1
title: Rosa and Gabriel between the coast and the interior of Brazil in the First Republic

description: Abstract The city of Uberaba, in the Triângulo Mineiro, Minas Gerais, played an important role in the intermediation of commerce that during the First Republic took place between the coffee economy of São Paulo and the interior of Brazil. This intermediation had as protagonists uberabenses that, in different forms, ﬁt in that commercial circuit; many of whom owned businesses that stretched north to south, going from the interior to the coast and, in some cases, to the European continent. This article aims to follow the developments of some of these commercial networks, focusing on two important actors: Rosa Maria de Oliveira and Gabriel Orlando Teixeira Junqueira.
DOI: 10.6084/m9.figshare.9985997.v1
title: CASE SERIES OF PATIENTS UNDER BIWEEKLY TREATMENT WITH LARONIDASE: A REPORT OF A SINGLE CENTER EXPERIENCE

description: ABSTRACT Objective: To report the stabilization of urinary glycosaminoglicans (GAG) excretion and clinical improvements in patients with mucopolysaccharidosis type I (MPS I) under an alternative dose regimen of laronidase of 1.2 mg/kg every other week. Methods: We participated in a dose-optimization trial for laronidase in MPS-I patients using four alternative regimens: 0.58 mg/kg every week, 1.2 mg/kg every two weeks, 1.2 mg/kg every week and 1.8 mg/kg every other week (EOW). After the trial ended, the patients resumed the recommended dose and regimen of 0.58 mg/kg every week. Under this regimen, some patients presented difficulties in venous access and were unable to commute weekly to the treatment center. Therefore, we used an alternative regimen that consisted of 1.2 mg/kg EOW in eight patients. A retrospective study of medical records of MPS-I patients who underwent both enzyme replacement therapy (ERT) regimens, of 0.58 mg/kg every week and 1.2 mg/kg EOW, was done. Results: Patients remained clinically stable under the alternative regimen, did not present elevation of urinary GAG nor any adverse event. Conclusions: The switch of dose regimen to 1.2 mg/kg EOW of laronidase was safe, and did not cause any clinical worsening in patients who had been previously under standard dose ERT.
DOI: 10.6084/m9.figshare.9986000.v1
title: Risk factors associated with viral infections (BoHV-1 and BVDV) in crossbreed dairy herds with reproductive failures, Uberlândia, MG

description: ABSTRACT Viral infections are frequently associated with reproductive problems in dairy and beef cattle worldwide. The aim of this study was to verify managerial practices that may constitute risk factors associated with infection by BoHV-1 and/or BVDV in dairy herds with a history of reproductive disease in extensively reared dairy cows without a previous history of vaccination against IBR and BVD. Neutralizing antibodies anti-BoHV-1, anti-BVDV or both were detected in 62.5% (165/264), 45.1% (119/264), and 31.4% (83/264), respectively, in the samples analyzed. The risk factors associated with infection by BoHV-1 were herds with more than 100 cows, the presence of mechanical milking, the non-utilization of artificial insemination, and the infrequent acquisition of animals. Risk factors associated with BVDV were dual-purpose herds (milk and beef), these include the utilization of mechanical milking, absence of quarantine for newly acquired animals, the presence of picket calving, and the absence of artificial insemination. For simultaneous infections by both viruses (BoHV-1 and BVDV) the use of mechanical milking increased the chance of infection 3.36-fold while the use of artificial insemination reduced the risk of infection by 56% in these herds.
DOI: 10.6084/m9.figshare.9985979
title: Correlation between radiographic and ecocardiographic findings suggestive of cardiomegaly in 104 dogs

description: ABSTRACT Thoracic radiographs and echocardiograms of 104 canines were evaluated and correlated regarding cardiac chambers enlargement. The radiographic findings were statistically correlated in order to establish the accuracy of the radiographic examination in the detection of cardiac enlargement in comparison with the echocardiogram - non-invasive gold standard. The correlation between the radiographic findings indicative of cardiac enlargement and echocardiographic indexes was weak, significant only for VHS versus left atrium to aorta ratio (r= 0.3136), short axis versus left atrium to aorta ratio (r= 0, 3813) and short axis versus E wave velocity (r= 0.2021). The radiographic accuracy in the subjective determination of cardiac chamber enlargement was reasonable, ranging from 72.1% to 80.8%. On the other hand, VHS presented low accuracy (50.9%) in the detection of cardiomegaly.
DOI: 10.6084/m9.figshare.9985985
title: Neuroaxonal Dystrophy in a mule: first case reported

description: ABSTRACT A 12-month-old mule (sterile hybrid equine species) presented unspecific neurological changes (symmetric ataxia, dysmetria, conscious proprioceptive deficit and weakness). Due to poor prognosis and to the fact that a sibling from the previous generation exhibited similar clinical signs that were not definitively diagnosed, the animal was euthanized. Diagnosis of neuroaxonal dystrophy was confirmed by anatomohistopathological analysis. This is the first clinical case of neuronal dystrophy in a mule reported in the world. The clinical and histopathological characteristics of this disease were very similar to those reported for several equine breeds. Therefore, the disease should also be considered in the diagnosis of neurological conditions in mules and donkeys.
DOI: 10.6084/m9.figshare.9985988
title: Individualization of soil classes by disaggregation of physiographic map polygons

description: Abstract: The objective of this work was to disaggregate the polygons of physiographic map units in order to individualize the soil classes in each one, representing them as simple soil map units and generating a more detailed soil map than the original one, making these data more useful for future reference. A physiographic map, on a 1:25,000 scale, of the Tarumãzinho watershed, located in the municipality of Águas Frias, in the state of Santa Catarina, Brazil, was used. For disaggregation, three geomorphometric parameters were applied: slope and landforms, both derived from the digital terrain model; and an elevation map. The boundaries of the physiographic units and the elevation, slope, and landform maps were subjected to cross tabulation to identify the existing combinations between the soil classes of each physiographic unit. Based on these combinations, rules were established to select typical areas of occurrence of each soil type in order to train a decision tree model to predict the occurrence of soil classes. The model was trained using the Weka software and was validated with a set of georeferenced soil profiles. Disaggregation enables the individualization and spatialization of soil classes and is useful in producing detailed soil maps.
DOI: 10.6084/m9.figshare.9985988.v1
title: Individualization of soil classes by disaggregation of physiographic map polygons

description: Abstract: The objective of this work was to disaggregate the polygons of physiographic map units in order to individualize the soil classes in each one, representing them as simple soil map units and generating a more detailed soil map than the original one, making these data more useful for future reference. A physiographic map, on a 1:25,000 scale, of the Tarumãzinho watershed, located in the municipality of Águas Frias, in the state of Santa Catarina, Brazil, was used. For disaggregation, three geomorphometric parameters were applied: slope and landforms, both derived from the digital terrain model; and an elevation map. The boundaries of the physiographic units and the elevation, slope, and landform maps were subjected to cross tabulation to identify the existing combinations between the soil classes of each physiographic unit. Based on these combinations, rules were established to select typical areas of occurrence of each soil type in order to train a decision tree model to predict the occurrence of soil classes. The model was trained using the Weka software and was validated with a set of georeferenced soil profiles. Disaggregation enables the individualization and spatialization of soil classes and is useful in producing detailed soil maps.
DOI: 10.6084/m9.figshare.9985970
title: Phenotypic correlation of characteristics in the gilt performance test with an average number of live-born piglets through all achieved births, during the reproductive exploitation

description: ABSTRACT Reproductive efficacy of sows dictates the level of profitability of the production itself, and the moment of testing and selection of gilts for breeding (as the parents of a future generation), represents a very important moment. Given the fact that the selection of gilts for breeding is partly based on the weight-gain in the test, in this study we examined the influence of a daily weight-gain of gilts in the test of the manifestation of important reproductive characteristics - the size of the litter of the first and the other parities, as well as the percentage of sows that gave birth in relation to previous breeding process. Data of the 11637 tested gilts that completed the performance test have been used for the test. The studied characteristics were: the weight-gain at the end of the test, the number of live-born piglets, the number of stillborn piglets and the number of grown-weaned piglets in the first litter and the total number of live-born piglets, the total number of stillborn piglets and the total number of grown-weaned piglets. The results obtained in this study showed the effect of weight-gain in the reproductive efficacy test in the number of the live-born piglets in the first and from the 2nd to the 9th parity, as well as the percentage of the sows included in the next breeding process. By including all selected independent variables that showed the adequate statistical significance in correlation with the dependent variable, the determination coefficient rises to a value of 0.098 which represents 9.80% of the influence on the dependent variable, that can be explained by the independent variable, which leads to the conclusion that the binding strength between the variable "average live" and all the independent variables: “the number of litters”, the MLD depth” and “the back-fat thickness”, is very weak, which is not a rare case in multiple regression.
DOI: 10.6084/m9.figshare.9985976
title: Histopathology and immunohistochemistry of peripheral neural sheath tumor and perivascular wall tumor in dog

description: ABSTRACT Soft tissue sarcomas (STS) comprise a heterogeneous group of malignancies derived from extra-skeletal mesenchymal tissues that may show similar histopathological changes. Histopathologic patterns suggestive of perivascular wall tumors (PWT) and peripheral nerve sheath tumors (PNST) have been described. This study investigated the histogenesis in a series of 71 cases of canine STS that showed morphological compatibility with what is described for PWT and PNST. Immunohistochemistry analysis were done to CD56, S100, SMA, Desmin, Von Willebrand Factor, NSE and GFAP. Twenty-one cases (29.6%) showed histopathologic features compatible with PWT, 23 cases (32.4%) with PNST and 27 cases (38.0%) shared both histopathological features. By immunohistochemistry, 59 (83.1%) cases showed positivity only for neural markers and 12 (16.9%) had simultaneous positivity for both neural and muscle markers. PNST was the most prevalent neoplasm and none of the cases were positive for muscle markers only. The histopathologic features were not useful to define the diagnosis of PWT, since most tumors were negative for muscle markers but positive for neural markers. Due to this immunoreactivity and the morphologic features, future studies may propose guidelines for the classification of these neoplasms.
DOI: 10.6084/m9.figshare.9985985.v1
title: Neuroaxonal Dystrophy in a mule: first case reported

description: ABSTRACT A 12-month-old mule (sterile hybrid equine species) presented unspecific neurological changes (symmetric ataxia, dysmetria, conscious proprioceptive deficit and weakness). Due to poor prognosis and to the fact that a sibling from the previous generation exhibited similar clinical signs that were not definitively diagnosed, the animal was euthanized. Diagnosis of neuroaxonal dystrophy was confirmed by anatomohistopathological analysis. This is the first clinical case of neuronal dystrophy in a mule reported in the world. The clinical and histopathological characteristics of this disease were very similar to those reported for several equine breeds. Therefore, the disease should also be considered in the diagnosis of neurological conditions in mules and donkeys.
DOI: 10.6084/m9.figshare.9985967
title: Public higher education in Brazil: costs, benefits and distributive effects

description: Abstract This paper addresses one aspect of equity: income, associated with the access to and funding of public universities in Brazil. As in other countries, the usual perception is that Brazilian public universities are free and attended mainly by high income students. In line with Barbaro (2005), considering the main public spending with higher education and the related tax costs, we estimate a net benefit by income decile. We observe for Brazil a net transfer of the richest 20% to the rest of the population and a concentration of net benefit in the 4th to the 7th decile range of per capita household income. Therefore, considering only the public budget for higher education, this net transfer would not reach the poorest 30% of the population, but it would still mitigate the significant inequality of Brazilian income.
DOI: 10.6084/m9.figshare.9985973
title: Evaluation of resistance in Eucalyptus grandis progenies against leaf spot of Cylindrocladium and Kirramyces

description: ABSTRACT During cultivation of eucalyptus, there are several diseases, which can limit its productivity, such as leaf spots caused by Cylindrocladium spp. and Kirramyces epicoccoides. Therefore, the objective of this study was to evaluate the resistance of Eucalyptus grandis progenies to these diseases. A progeny test with 176 progenies and three commercial controls for comparison was installed in two locations: Anhembi and Itatinga, São Paulo State, Brazil. Leaf spot incidence and severity were evaluated when plants were 12 and 24 months old (Anhembi) and 15 and 27 months old (Itatinga). Severity was evaluated based on a scale varying from one (healthy) to five (up to 2/3 canopy defoliation). The incidence and mean severity obtained by progenies were compared to those of controls (commercial varieties) and between locations. Spatialization of the disease was also performed in the test areas. Some progenies had mean severity lower than that of commercial controls, indicating potential for use in breeding programs for resistance to leaf spot. There is variation among the progenies in relation to resistance to leaf spot and consequently possibility of gaining with the selection among the best progenies.
DOI: 10.6084/m9.figshare.9985976.v1
title: Histopathology and immunohistochemistry of peripheral neural sheath tumor and perivascular wall tumor in dog

description: ABSTRACT Soft tissue sarcomas (STS) comprise a heterogeneous group of malignancies derived from extra-skeletal mesenchymal tissues that may show similar histopathological changes. Histopathologic patterns suggestive of perivascular wall tumors (PWT) and peripheral nerve sheath tumors (PNST) have been described. This study investigated the histogenesis in a series of 71 cases of canine STS that showed morphological compatibility with what is described for PWT and PNST. Immunohistochemistry analysis were done to CD56, S100, SMA, Desmin, Von Willebrand Factor, NSE and GFAP. Twenty-one cases (29.6%) showed histopathologic features compatible with PWT, 23 cases (32.4%) with PNST and 27 cases (38.0%) shared both histopathological features. By immunohistochemistry, 59 (83.1%) cases showed positivity only for neural markers and 12 (16.9%) had simultaneous positivity for both neural and muscle markers. PNST was the most prevalent neoplasm and none of the cases were positive for muscle markers only. The histopathologic features were not useful to define the diagnosis of PWT, since most tumors were negative for muscle markers but positive for neural markers. Due to this immunoreactivity and the morphologic features, future studies may propose guidelines for the classification of these neoplasms.
DOI: 10.6084/m9.figshare.9985979.v1
title: Correlation between radiographic and ecocardiographic findings suggestive of cardiomegaly in 104 dogs

description: ABSTRACT Thoracic radiographs and echocardiograms of 104 canines were evaluated and correlated regarding cardiac chambers enlargement. The radiographic findings were statistically correlated in order to establish the accuracy of the radiographic examination in the detection of cardiac enlargement in comparison with the echocardiogram - non-invasive gold standard. The correlation between the radiographic findings indicative of cardiac enlargement and echocardiographic indexes was weak, significant only for VHS versus left atrium to aorta ratio (r= 0.3136), short axis versus left atrium to aorta ratio (r= 0, 3813) and short axis versus E wave velocity (r= 0.2021). The radiographic accuracy in the subjective determination of cardiac chamber enlargement was reasonable, ranging from 72.1% to 80.8%. On the other hand, VHS presented low accuracy (50.9%) in the detection of cardiomegaly.