cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.19681756.v1
title: CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway

description: Ovarian cancers are the major cause of mortality for women worldwide. This study was aimed to elucidate the biological activities of CCDC106 in the proliferation and invasion of mutant p53 and of wild-type p53 ovarian cancer cells. CAOV3 (mutant p53) cells showed high expression levels of CCDC106, but it was expressed at low levels in SKOV3 (mutant p53) and in A2780 (wild-type p53) cells. The overexpression of CCDC106 promoted the expression of proliferation markers (cyclin family members), invasion and Epithelial-to-mesenchymal transition (EMT) markers (claudin-1, claudin-4, N-cadherin, snail, slug) while the knockdown of CCDC106 inhibited their expression in mutant p53 cells but not in wild-type p53 cells. Treatment with a CK2 inhibitor blocked the translocation of CCDC106 into the nuclei of mutant p53 cells. Immunoprecipitation assays confirmed that ATF4 is a potential binding partner of CCDC106. The overexpression of CCDC106 reduced p21 and p27 protein expression levels while treatment with an ATF4 siRNA rescued their expression. The overexpression of CCDC106 promoted colony formation and invasion of mutant p53 cells, which was suppressed by treatment with an ATF4 siRNA. Immunohistochemistry results showed that CCDC106 and ATF4 are expressed at high levels but p21 is expressed at low levels in FIGO III–IV stage and in mutant p53 ovarian cancer samples. A significant association between poor overall survival and high CCDC106 and ATF4 expression levels was observed in human ovarian cancer samples. In conclusion, CCDC106 promotes proliferation, invasion and EMT of mutant p53 ovarian cancer cells via the ATF4 mediated inhibition of p21.
DOI: 10.6084/m9.figshare.11294189
title: MOESM1 of Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

description: Additional file 1: Table S1. T-stats* and adjusted p-values.
DOI: 10.6084/m9.figshare.11294189.v1
title: MOESM1 of Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

description: Additional file 1: Table S1. T-stats* and adjusted p-values.
DOI: 10.6084/m9.figshare.8148488
title: Additional file 1: of Time series analysis of mumps and meteorological factors in Beijing, China

description: Table S1. Monthly mumps data from January 1990 to December 2012, Beijing, China. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.8148494.v1
title: Additional file 2: of Time series analysis of mumps and meteorological factors in Beijing, China

description: Table S2. Monthly means derived from daily average values of meteorological parameters measured from 1989 to 2012 in Beijing, China. (XLSX 26 kb)
DOI: 10.17608/k6.auckland.19158647
title: B Scans

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158647.v1
title: B Scans

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158650
title: Gentoo ASOCT

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158653
title: King ASOCT

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158653.v1
title: King ASOCT

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.34770/haxf-3c93
title: Data for "Improved stellarator permanent magnet designs through combined discrete and continuous optimizations"

description: This archive contains data related to the paper, "Improved
 stellarator permanent magnet designs through combined discrete and
 continuous optimizations", published in Computer Physics
 Communications (https://doi.org/10.1016/j.cpc.2024.109127). Included are
 data plotted in the figures, as well as input and output files for some
 optimizations and equilibrium models.
DOI: 10.17608/k6.auckland.19158656
title: Little pupils

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158656.v1
title: Little pupils

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158659
title: Corneal topography

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158659.v1
title: Corneal topography

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158662
title: Gentoo pupils

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158662.v1
title: Gentoo pupils

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158665
title: King pupils

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158665.v1
title: King pupils

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158668
title: Gentoo A scans

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158668.v1
title: Gentoo A scans

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158671
title: Keratoscopy

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158671.v1
title: Keratoscopy

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.17608/k6.auckland.19158674
title: Little ASOCT

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.6084/m9.figshare.14963343.v1
title: Construction of a DLBCL Prognostic Signature Based on Tumor Microenvironment

description: Diffuse large B-cell lymphoma (DLBCL) is a common curable non-Hodgkin’s lymphoma. Patients with this disease can be cured after the R-CHOP immunochemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Nonetheless, most cured patients will relapse again and have dismal prognosis. In this study, we aim to identify a potential biomarker by analyzing gene expression data, and to predict patient’s survival rate by constructing a risk model. Firstly, mRNA chip data (GSE87371) and clinical data of DLBCL patients were obtained from Gene Expression Omnibus (GEO). Samples were scored with estimate package. The obtained stromal score (<i>P</i> &lt; 0.05) and ESTIMATE score (<i>P</i> &lt; 0.05) were significantly correlated with the prognosis. Differentially expressed genes (DEGs) screened through the above two scoring methods were intersected and 279 DEGs were obtained. Next, five feature genes (CD163, CLEC4A, COL15A1, GABRB2, IFIT3) were identified by univariate Cox, LASSO and multivariate Cox regression analyses to establish a risk evaluation model. Thereafter, the 5-gene risk model was validated on a validation set. ROC and survival analyses were performed to assess the performance of the model. Further analysis showed that the risk model was capable of independently determining the prognosis of patients, and a nomogram was sequentially established. Authors screened DEGs related to ESTIMATE and stromal scores from GEO database, and established a 5-gene prognostic signature through Cox regression analysis and LASSO analysis. The risk model and nomogram will help individuals accurately predict the prognosis of DLBCL patients.
DOI: 10.17608/k6.auckland.19158674.v1
title: Little ASOCT

description: Part of a collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.
DOI: 10.6084/m9.figshare.8148062
title: MOESM4 of Effect of cold atmospheric plasma treatment on the metabolites of human leukemia cells

description: Additional file 4: Table S4. Pathway analysis.
DOI: 10.6084/m9.figshare.14963444
title: The role of CCR2 in prognosis of patients with endometrial cancer and tumor microenvironment remodeling

description: Tumor microenvironment (TME) plays a core role in the genesis and progress of endometrial carcinoma (EC). The immune system, a crucial element of TME, functions in various immune cells. In this paper, we have tried to evaluate the prognosis in EC patients by the status of TME. The ESTIMATE algorithm was implemented to computer the number of immune and stromal components in EC tissues from the Cancer Genome Atlas dataset. The CIBERSORT algorithm was employed to assess the proportion of tumor-infiltrating immune cells in EC tissues, which were quantified as Stromal score and Immune score. After the construction of protein–protein interaction network, cell–cell chemokine receptor 2 (CCR2) was identified as a potential predictive element for EC. Further analysis indicated that a higher expression of CCR2 in EC patients was correlated with a better prognosis and a prolonged disease-free survival. According to the transcript level of CCR2, samples were separated into low- and high-expression groups. Gene Set Enrichment Analysis unveiled that metabolism-related pathways were mostly abundant in groups with high-expression, the other one was primarily correlated to immune-related activities. We figured out that some immune cells were positively related to CCR2, suggesting that CCR2 might serve as the immune-dominant status of TME, which was verified by qRT-PCR and HPA analysis in transcriptome and protein level, respectively. Also, CCR2 showed high correlation with immune modulators and chemokine signaling pathway. Thus, the level of CCR2 might have a prognostic value for EC patients, which provides a novel insight for therapeutic strategies of EC.
DOI: 10.6084/m9.figshare.19682403.v1
title: Targeting CC chemokine ligand (CCL) 20 by miR-143-5p alleviate lead poisoning-induced renal fibrosis by regulating interstitial fibroblasts excessive proliferation and dysfunction

description: Environmental lead contamination can cause chronic renal disease with a common clinical manifestation of renal fibrosis and constitutes a major global public health threat. Aberrant proliferation and extracellular matrix (ECM) accumulation in renal interstitial fibroblasts are key pathological causes of renal fibrosis. However, the mechanism underlying lead-induced kidney fibrosis remains unclear. The present study analyzed gene expression prolifes in lead acetate-treated primary mice renal interstitial fibroblasts and confirmed the aberrant expression of CC chemokine ligand (CCL) 20, one of the most obvious up-regulated genes. Analogously, lead acetate exposure dose-dependently increased CCL20 transcription, protein expression and release. Knockdown of CCL20 suppressed lead acetate-induced fibroblast proliferation, hydroxyproline contents, transforming growth factor-beta production and ECM-related protein (Collagen I and fibronectin) expression. Bioinformatics analysis predicted five top miRNAs targeting CCL20. Among them, miR-143-5p expression was dose-dependently decreased in lead acetate-treated fibroblasts. Mechanistically, miR-143-5p directly targeted CCL20. Elevation of miR-143-5p antagonized lead acetate-induced fibroblast proliferation, hydroxyproline and ECM-related protein expression, which were reversed by CCL20 overexpression. Additionally, CCL20 knockdown suppressed lead acetate-mediated Smad2/3 and AKT pathway activation. Notably, miR-143-5p overexpression attenuated the activation of the Smad2/3 and AKT pathway in lead acetate-exposed fibroblasts, which was counteracted by CCL20 elevation. miR-143-5p injection ameliorated renal fibrosis progression in mice <i>in vivo</i>. Thus, targeting CCL20 by miR-143-5p could alleviate renal fibrosis progression by regulating fibroblast proliferation and ECM deposition via the Smad2/3 and AKT signaling, providing a potential therapeutic target for environmental lead contamination-evoked fibrotic kidney disease.
DOI: 10.5519/qd.oxj32ihe
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (8833 records)
DOI: 10.6084/m9.figshare.19681955
title: Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/<i>XIAP</i> axis

description: Hepatocellular carcinoma (HCC) is characterized by a high mortality rate. Dysregulated circular RNAs (circRNAs) play a vital role in HCC. We aimed to study the role of circ_0003528 in HCC and its fundamental molecular mechanisms. HSA_circ_0003528 was identified through bioinformatics dataset analysis. The binding sites between mRNA and miRNA were predicted using online bioinformatics tools. The interaction between miR-212-3p and X-linked inhibitor of apoptosis protein (<i>XIAP</i>) or circ_0003528 was confirmed through the luciferase reporter assay. RT-qPCR and western blot assays were used to analyze the expression of all miRNAs/mRNAs and proteins. Cellular functions were evaluated using the MTT and TUNEL assays. A xenograft model was established to evaluate the function of circ_0003528 <i>in vivo</i>. Circ_0003528 was dramatically overexpressed in HepG2 and HUH7 cells. However, knockdown of circ_0003528 suppressed the aggressiveness of HCC cells and tumor growth both <i>in vitro</i> and <i>in vivo</i>. Furthermore, binding of miR-212-3p to circ_0003528 and <i>XIAP</i> was verified. Downregulation of miR-212-3p abrogated the effects of si-circ_0003528 on cell viability and apoptosis, and upregulation of <i>XIAP</i> antagonized the functions of the miR-212-3p mimic in HCC cells. circ_0003528 contributes to the development of HCC <i>in vitro</i> and <i>in vivo</i> via the miR-212-3p/<i>XIAP</i> axis. Hence, circ_0003528 knockdown may be a potential therapeutic strategy for HCC treatment.