cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1294147.v2
title: The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells

description: The mammalian ortholog of Drosophila ecdysoneless (Ecd) gene product regulates Rb-E2F interaction and is required for cell cycle progression. Ecd is overexpressed in breast cancer and its overexpression predicts shorter survival in patients with ErbB2-positive tumors. Here, we demonstrate Ecd knock down (KD) in human mammary epithelial cells (hMECs) induces growth arrest, similar to the impact of Ecd Knock out (KO) in mouse embryonic fibroblasts. Furthermore, whole-genome mRNA expression analysis of control vs. Ecd KD in hMECs demonstrated that several of the top 40 genes that were down-regulated were E2F target genes. To address the role of Ecd in mammary oncogenesis, we overexpressed Ecd and/or mutant H-Ras in hTERT-immortalized hMECs. Cell cycle analyses revealed hMECs overexpressing Ecd+Ras showed incomplete arrest in G1 phase upon growth factor deprivation, and more rapid cell cycle progression in growth factor-containing medium. Analyses of cell migration, invasion, acinar structures in 3-D Matrigel and anchorage-independent growth demonstrated that Ecd+Ras-overexpressing cells exhibit substantially more dramatic transformed phenotype as compared to cells expressing vector, Ras or Ecd. Under conditions of nutrient deprivation, Ecd+Ras-overexpressing hMECs exhibited better survival, with substantial upregulation of the autophagy marker LC3 both at the mRNA and protein levels. Significantly, while hMECs expressing Ecd or mutant Ras alone did not form tumors in NOD/SCID mice, Ecd+Ras-overexpressing hMECs formed tumors, clearly demonstrating oncogenic cooperation between Ecd and mutant Ras. Collectively, we demonstrate an important co-oncogenic role of Ecd in the progression of mammary oncogenesis through promoting cell survival.
DOI: 10.6084/m9.figshare.1294145
title: A new pistosauroid (Reptilia, Sauropterygia) from the late Ladinian Xingyi marine reptile level, southwestern China

description: http://zoobank.org/urn:lsid:zoobank.org:pub:E77AE32E-0E07-4FE1-9ABA-0DFBA1B47672 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1294145.v2
title: A new pistosauroid (Reptilia, Sauropterygia) from the late Ladinian Xingyi marine reptile level, southwestern China

description: http://zoobank.org/urn:lsid:zoobank.org:pub:E77AE32E-0E07-4FE1-9ABA-0DFBA1B47672 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1294145.v1
title: A new pistosauroid (Reptilia, Sauropterygia) from the late Ladinian Xingyi marine reptile level, southwestern China

description: http://zoobank.org/urn:lsid:zoobank.org:pub:E77AE32E-0E07-4FE1-9ABA-0DFBA1B47672 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1294142
title: A Permutation Approach to Testing Interactions for Binary Response by Comparing Correlations Between Classes

description: To date testing interactions in high dimensions is a challenging task. Existing methods often have issues with sensitivity to modeling assumptions and heavily asymptotic nominal <i>p</i>-values. To help alleviate these issues, we propose a permutation-based method for testing marginal interactions with a binary response. Our method searches for pairwise correlations that differ between classes. In this article, we compare our method on real and simulated data to the standard approach of running many pairwise logistic models. On simulated data our method finds more significant interactions at a lower false discovery rate (especially in the presence of main effects). On real genomic data, although there is no gold standard, our method finds apparent signal and tells a believable story, while logistic regression does not. We also give asymptotic consistency results under not too restrictive assumptions. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.1294142.v1
title: A Permutation Approach to Testing Interactions for Binary Response by Comparing Correlations Between Classes

description: To date testing interactions in high dimensions is a challenging task. Existing methods often have issues with sensitivity to modeling assumptions and heavily asymptotic nominal <i>p</i>-values. To help alleviate these issues, we propose a permutation-based method for testing marginal interactions with a binary response. Our method searches for pairwise correlations that differ between classes. In this article, we compare our method on real and simulated data to the standard approach of running many pairwise logistic models. On simulated data our method finds more significant interactions at a lower false discovery rate (especially in the presence of main effects). On real genomic data, although there is no gold standard, our method finds apparent signal and tells a believable story, while logistic regression does not. We also give asymptotic consistency results under not too restrictive assumptions. Supplementary materials for this article are available online.
DOI: 10.23645/epacomptox.6062488.v4
title: ReadMe File for ToxCast and Tox21 summary files

description: ReadMe file providing guidance for the ToxCast and Tox21 summary files.
DOI: 10.6084/m9.figshare.1294140
title: A new aetosaur (Archosauria, Suchia) from the Upper Triassic Pekin Formation, Deep River Basin, North Carolina, U.S.A., and its implications for early aetosaur evolution

description: ABSTRACTAetosaurs are an extinct clade of quadrupedal, heavily armored archosaurs that had a worldwide distribution during the Late Triassic. Aetosaur fossils from the Upper Triassic Pekin Formation in the Deep River Basin of North Carolina (U.S.A.) consist primarily of isolated osteoderms and, rarely, more associated material. Here we describe a new genus and species, <i>Gorgetosuchus pekinensis</i>, based on an associated incomplete anterior carapace, consisting of a total of 19 nearly complete paramedian and lateral osteoderms from the first 10 rows of armor as well as some associated fragments. An important feature of <i>Gorgetosuchus</i> is that an articulated fifth row of cervical osteoderms almost encloses the neck, with prominent spines on both the dorsal and lateral osteoderms. This is a novel configuration among aetosaurs. Otherwise, NCSM 21723 preserves a mosaic of character states found in <i>Longosuchus</i>, <i>Lucasuchus</i>, or both taxa while simultaneously preserving several more plesiomorphic character states, such as cervical osteoderms that are wider than long. Our reevaluation of other Pekin Formation specimens that various authors have assigned to <i>Desmatosuchus</i>, <i>Longosuchus</i>, or <i>Lucasuchus</i> confirms that some possess characteristics of <i>Lucasuchus</i>, whereas others are not generically determinate. Incorporating <i>Gorgetosuchus</i> into existing phylogenies of aetosaurs results in a reshuffling of basal aetosaur relationships, but a variety of analyses consistently place <i>Gorgetosuchus</i> as a basal desmatosuchine. Using current taxonomic practices, there are at least three aetosaur genera in the Pekin Formation: <i>Lucasuchus</i>, <i>Coahomasuchus</i>, and <i>Gorgetosuchus.</i>http://zoobank.org/urn:lsid:zoobank.org:pub:5503A4F4-85DE-4B47-9E58-6C9F903A1640 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1294140.v1
title: A new aetosaur (Archosauria, Suchia) from the Upper Triassic Pekin Formation, Deep River Basin, North Carolina, U.S.A., and its implications for early aetosaur evolution

description: ABSTRACTAetosaurs are an extinct clade of quadrupedal, heavily armored archosaurs that had a worldwide distribution during the Late Triassic. Aetosaur fossils from the Upper Triassic Pekin Formation in the Deep River Basin of North Carolina (U.S.A.) consist primarily of isolated osteoderms and, rarely, more associated material. Here we describe a new genus and species, <i>Gorgetosuchus pekinensis</i>, based on an associated incomplete anterior carapace, consisting of a total of 19 nearly complete paramedian and lateral osteoderms from the first 10 rows of armor as well as some associated fragments. An important feature of <i>Gorgetosuchus</i> is that an articulated fifth row of cervical osteoderms almost encloses the neck, with prominent spines on both the dorsal and lateral osteoderms. This is a novel configuration among aetosaurs. Otherwise, NCSM 21723 preserves a mosaic of character states found in <i>Longosuchus</i>, <i>Lucasuchus</i>, or both taxa while simultaneously preserving several more plesiomorphic character states, such as cervical osteoderms that are wider than long. Our reevaluation of other Pekin Formation specimens that various authors have assigned to <i>Desmatosuchus</i>, <i>Longosuchus</i>, or <i>Lucasuchus</i> confirms that some possess characteristics of <i>Lucasuchus</i>, whereas others are not generically determinate. Incorporating <i>Gorgetosuchus</i> into existing phylogenies of aetosaurs results in a reshuffling of basal aetosaur relationships, but a variety of analyses consistently place <i>Gorgetosuchus</i> as a basal desmatosuchine. Using current taxonomic practices, there are at least three aetosaur genera in the Pekin Formation: <i>Lucasuchus</i>, <i>Coahomasuchus</i>, and <i>Gorgetosuchus.</i>http://zoobank.org/urn:lsid:zoobank.org:pub:5503A4F4-85DE-4B47-9E58-6C9F903A1640 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1294140.v3
title: A new aetosaur (Archosauria, Suchia) from the Upper Triassic Pekin Formation, Deep River Basin, North Carolina, U.S.A., and its implications for early aetosaur evolution

description: ABSTRACTAetosaurs are an extinct clade of quadrupedal, heavily armored archosaurs that had a worldwide distribution during the Late Triassic. Aetosaur fossils from the Upper Triassic Pekin Formation in the Deep River Basin of North Carolina (U.S.A.) consist primarily of isolated osteoderms and, rarely, more associated material. Here we describe a new genus and species, <i>Gorgetosuchus pekinensis</i>, based on an associated incomplete anterior carapace, consisting of a total of 19 nearly complete paramedian and lateral osteoderms from the first 10 rows of armor as well as some associated fragments. An important feature of <i>Gorgetosuchus</i> is that an articulated fifth row of cervical osteoderms almost encloses the neck, with prominent spines on both the dorsal and lateral osteoderms. This is a novel configuration among aetosaurs. Otherwise, NCSM 21723 preserves a mosaic of character states found in <i>Longosuchus</i>, <i>Lucasuchus</i>, or both taxa while simultaneously preserving several more plesiomorphic character states, such as cervical osteoderms that are wider than long. Our reevaluation of other Pekin Formation specimens that various authors have assigned to <i>Desmatosuchus</i>, <i>Longosuchus</i>, or <i>Lucasuchus</i> confirms that some possess characteristics of <i>Lucasuchus</i>, whereas others are not generically determinate. Incorporating <i>Gorgetosuchus</i> into existing phylogenies of aetosaurs results in a reshuffling of basal aetosaur relationships, but a variety of analyses consistently place <i>Gorgetosuchus</i> as a basal desmatosuchine. Using current taxonomic practices, there are at least three aetosaur genera in the Pekin Formation: <i>Lucasuchus</i>, <i>Coahomasuchus</i>, and <i>Gorgetosuchus.</i>http://zoobank.org/urn:lsid:zoobank.org:pub:5503A4F4-85DE-4B47-9E58-6C9F903A1640 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1294140.v2
title: A new aetosaur (Archosauria, Suchia) from the Upper Triassic Pekin Formation, Deep River Basin, North Carolina, U.S.A., and its implications for early aetosaur evolution

description: ABSTRACTAetosaurs are an extinct clade of quadrupedal, heavily armored archosaurs that had a worldwide distribution during the Late Triassic. Aetosaur fossils from the Upper Triassic Pekin Formation in the Deep River Basin of North Carolina (U.S.A.) consist primarily of isolated osteoderms and, rarely, more associated material. Here we describe a new genus and species, <i>Gorgetosuchus pekinensis</i>, based on an associated incomplete anterior carapace, consisting of a total of 19 nearly complete paramedian and lateral osteoderms from the first 10 rows of armor as well as some associated fragments. An important feature of <i>Gorgetosuchus</i> is that an articulated fifth row of cervical osteoderms almost encloses the neck, with prominent spines on both the dorsal and lateral osteoderms. This is a novel configuration among aetosaurs. Otherwise, NCSM 21723 preserves a mosaic of character states found in <i>Longosuchus</i>, <i>Lucasuchus</i>, or both taxa while simultaneously preserving several more plesiomorphic character states, such as cervical osteoderms that are wider than long. Our reevaluation of other Pekin Formation specimens that various authors have assigned to <i>Desmatosuchus</i>, <i>Longosuchus</i>, or <i>Lucasuchus</i> confirms that some possess characteristics of <i>Lucasuchus</i>, whereas others are not generically determinate. Incorporating <i>Gorgetosuchus</i> into existing phylogenies of aetosaurs results in a reshuffling of basal aetosaur relationships, but a variety of analyses consistently place <i>Gorgetosuchus</i> as a basal desmatosuchine. Using current taxonomic practices, there are at least three aetosaur genera in the Pekin Formation: <i>Lucasuchus</i>, <i>Coahomasuchus</i>, and <i>Gorgetosuchus.</i>http://zoobank.org/urn:lsid:zoobank.org:pub:5503A4F4-85DE-4B47-9E58-6C9F903A1640 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP
DOI: 10.6084/m9.figshare.1293718
title: Petrology and geochemistry of greywackes of the ~1.6 Ga Middle Aravalli Supergroup, northwest India: evidence for active margin processes

description: Geochemical and petrological studies of the well-preserved greywacke horizon of the ‘Middle Aravalli Group’ were carried out to constrain the early evolution of the Aravalli basin. Petrological and geochemical attributes of Middle Aravalli greywackes (MAGs) such as very poor sorting, high angularity of framework grains, presence of fresh plagioclase and K-feldspars, variable Chemical Index of Alteration (CIA) index (46.7–74.5, avg. 61), and high Index of Compositional Variability (ICV) value (~1.05) suggest rapid physical erosion accompanying an active tectonic regime. The sediments record post-depositional K-metasomatism and extraneous addition of 0–25% (avg. ~10%) K is indicated. Assuming close system behaviour of immobile elements during sedimentation, various diagnostic element ratios such as Th/Sc, La/Sc, Zr/Sc, and Co/Th, Eu anomaly and rare earth element patterns of MAG suggest that the Archaean Banded Gneissic Complex (BGC) basement was not the major source of sediments. In conjunction with the dominant 1.8–1.6 Ga detrital zircon age peaks of Middle Aravalli clastic rocks, these data rather indicate that the sediments were derived from a young differentiated continental margin-type arc of andesite–dacite–rhyodacite composition. A highly fractionated mid-oceanic-ridge-basalt-normalized trace element pattern of MAGs, with characteristic enrichment of large-ion lithophile elements (LILEs), depletion of heavy rare earth elements, negative Nb-Ta, Ti and P anomalies, positive Pb anomaly, and distinctive Nb/Ta, Zr/Sm, Th/Yb, and Ta/Yb, Ce/Pb ratios envelop the composition of modern continental arc magmas (andesite–dacite) of the Andes, suggesting a subduction zone tectonic setting for precursor magma. High magnitude of LILE enrichment and high Th/Yb ratios in these sediments indicate that thick continental crust (~70 km) underlay the ‘Middle Aravalli’ continental arc, similar to the Central Volcanic Zone of the modern Andes. We propose that eastward subduction of Delwara oceanic crust beneath the BGC continent led to the formation of a continental volcanic arc, which supplied detritus to the forearc basin situated to the west. This model also explains the opening of linear ensialic basins in the Bhilwara terrain, such as in Rajpura–Dariba and Rampura–Agucha in a classical back-arc extension regime, similar to the Andean continental margin of the Mesozoic. On the basis of the recent <sup>207</sup>Pb/<sup>206</sup>Pb detrital zircon age of Middle Aravalli sediment, a time frame between 1772 and 1586 Ma can be assigned for Middle Aravalli continental arc magmatism.
DOI: 10.6084/m9.figshare.1293718.v2
title: Petrology and geochemistry of greywackes of the ~1.6 Ga Middle Aravalli Supergroup, northwest India: evidence for active margin processes

description: Geochemical and petrological studies of the well-preserved greywacke horizon of the ‘Middle Aravalli Group’ were carried out to constrain the early evolution of the Aravalli basin. Petrological and geochemical attributes of Middle Aravalli greywackes (MAGs) such as very poor sorting, high angularity of framework grains, presence of fresh plagioclase and K-feldspars, variable Chemical Index of Alteration (CIA) index (46.7–74.5, avg. 61), and high Index of Compositional Variability (ICV) value (~1.05) suggest rapid physical erosion accompanying an active tectonic regime. The sediments record post-depositional K-metasomatism and extraneous addition of 0–25% (avg. ~10%) K is indicated. Assuming close system behaviour of immobile elements during sedimentation, various diagnostic element ratios such as Th/Sc, La/Sc, Zr/Sc, and Co/Th, Eu anomaly and rare earth element patterns of MAG suggest that the Archaean Banded Gneissic Complex (BGC) basement was not the major source of sediments. In conjunction with the dominant 1.8–1.6 Ga detrital zircon age peaks of Middle Aravalli clastic rocks, these data rather indicate that the sediments were derived from a young differentiated continental margin-type arc of andesite–dacite–rhyodacite composition. A highly fractionated mid-oceanic-ridge-basalt-normalized trace element pattern of MAGs, with characteristic enrichment of large-ion lithophile elements (LILEs), depletion of heavy rare earth elements, negative Nb-Ta, Ti and P anomalies, positive Pb anomaly, and distinctive Nb/Ta, Zr/Sm, Th/Yb, and Ta/Yb, Ce/Pb ratios envelop the composition of modern continental arc magmas (andesite–dacite) of the Andes, suggesting a subduction zone tectonic setting for precursor magma. High magnitude of LILE enrichment and high Th/Yb ratios in these sediments indicate that thick continental crust (~70 km) underlay the ‘Middle Aravalli’ continental arc, similar to the Central Volcanic Zone of the modern Andes. We propose that eastward subduction of Delwara oceanic crust beneath the BGC continent led to the formation of a continental volcanic arc, which supplied detritus to the forearc basin situated to the west. This model also explains the opening of linear ensialic basins in the Bhilwara terrain, such as in Rajpura–Dariba and Rampura–Agucha in a classical back-arc extension regime, similar to the Andean continental margin of the Mesozoic. On the basis of the recent <sup>207</sup>Pb/<sup>206</sup>Pb detrital zircon age of Middle Aravalli sediment, a time frame between 1772 and 1586 Ma can be assigned for Middle Aravalli continental arc magmatism.
DOI: 10.6084/m9.figshare.1293718.v1
title: Petrology and geochemistry of greywackes of the ~1.6 Ga Middle Aravalli Supergroup, northwest India: evidence for active margin processes

description: Geochemical and petrological studies of the well-preserved greywacke horizon of the ‘Middle Aravalli Group’ were carried out to constrain the early evolution of the Aravalli basin. Petrological and geochemical attributes of Middle Aravalli greywackes (MAGs) such as very poor sorting, high angularity of framework grains, presence of fresh plagioclase and K-feldspars, variable Chemical Index of Alteration (CIA) index (46.7–74.5, avg. 61), and high Index of Compositional Variability (ICV) value (~1.05) suggest rapid physical erosion accompanying an active tectonic regime. The sediments record post-depositional K-metasomatism and extraneous addition of 0–25% (avg. ~10%) K is indicated. Assuming close system behaviour of immobile elements during sedimentation, various diagnostic element ratios such as Th/Sc, La/Sc, Zr/Sc, and Co/Th, Eu anomaly and rare earth element patterns of MAG suggest that the Archaean Banded Gneissic Complex (BGC) basement was not the major source of sediments. In conjunction with the dominant 1.8–1.6 Ga detrital zircon age peaks of Middle Aravalli clastic rocks, these data rather indicate that the sediments were derived from a young differentiated continental margin-type arc of andesite–dacite–rhyodacite composition. A highly fractionated mid-oceanic-ridge-basalt-normalized trace element pattern of MAGs, with characteristic enrichment of large-ion lithophile elements (LILEs), depletion of heavy rare earth elements, negative Nb-Ta, Ti and P anomalies, positive Pb anomaly, and distinctive Nb/Ta, Zr/Sm, Th/Yb, and Ta/Yb, Ce/Pb ratios envelop the composition of modern continental arc magmas (andesite–dacite) of the Andes, suggesting a subduction zone tectonic setting for precursor magma. High magnitude of LILE enrichment and high Th/Yb ratios in these sediments indicate that thick continental crust (~70 km) underlay the ‘Middle Aravalli’ continental arc, similar to the Central Volcanic Zone of the modern Andes. We propose that eastward subduction of Delwara oceanic crust beneath the BGC continent led to the formation of a continental volcanic arc, which supplied detritus to the forearc basin situated to the west. This model also explains the opening of linear ensialic basins in the Bhilwara terrain, such as in Rajpura–Dariba and Rampura–Agucha in a classical back-arc extension regime, similar to the Andean continental margin of the Mesozoic. On the basis of the recent <sup>207</sup>Pb/<sup>206</sup>Pb detrital zircon age of Middle Aravalli sediment, a time frame between 1772 and 1586 Ma can be assigned for Middle Aravalli continental arc magmatism.
DOI: 10.6084/m9.figshare.1293651
title: #Ferguson1.22-1.23.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293653
title: High mannose-binding lectin serum levels are associated with diabetic retinopathy in type 2 diabetes

description: PONE-D-14-38336R1
DOI: 10.6084/m9.figshare.1293648
title: #Ferguson1.8-1.12.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293649
title: #Ferguson1.12-1.18.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293650
title: #Ferguson1.18-1.22.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293646
title: #Ferguson1.1-1.5.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293647
title: #Ferguson1.5-1.8.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293649.v1
title: #Ferguson1.12-1.18.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293648.v1
title: #Ferguson1.8-1.12.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293650.v1
title: #Ferguson1.18-1.22.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293645
title: #Ferguson12.28-1.1.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.
DOI: 10.6084/m9.figshare.1293646.v1
title: #Ferguson1.1-1.5.xlsx

description: Twitter data on #Ferguson. See Project Descritpion for details.