cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.15141263
title: TABLE 1 in Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe

description: TABLE 1. Data of specimens examined with final species classification. Abbreviations: BM — body mass (g); FA — forearm length (mm); nk — not known; NP — national park
SpeciesCollection1SexFABMLocalityDate2n/FNaLaephotis kirinyaga 2RCJF742♂28.04.0Comoé NP, Ivory Coast27.06.200232/508°45’N, 3°48’WNeoromicia guineensisRCJF717♀30.53.0Comoé NP, Ivory Coast27.06.200226/488°45’N, 3°48’WNycticeinops happoldorumRCJF671♂37.29.0Banco NP, Ivory Coast13.09.200224/445°23’N, 4°03’WN. schlieffeniiRCJF791♂31.04.8Niéguéni, Burkina Faso,23.02.200934/5010°39’N, 5°24’WPseudoromicia brunneaRCJF764♀35.88.0Banco NP, Ivory Coast13.09.200236/505°23’N, 4°03’WP. brunneaNone3♂nknkBanco NP, Ivory Coast–36/505°23’N, 4°03’W
1 — Specimens deposited in Research Collection Jakob Fahr (RCJF)
2 — Species classification based on 99% similarity in RAG2 between specimens from same location as karyotyped specimen and specimen JX276347
from Senegal, see Table 2
3 — Fetus of RCJF764
description: Published as part of Volleth, Marianne, Mayer, Frieder, Heller, Klaus-Gerhard, Müller, Stefan & Fahr, Jakob, 2023, Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe, pp. 37 in Acta Chiropterologica 25 (1) on page 37, DOI: 10.3161/15081109ACC2023.25.1.002, http://zenodo.org/record/10265140
DOI: 10.5281/zenodo.15141264
title: TABLE 1 in Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe

description: TABLE 1. Data of specimens examined with final species classification. Abbreviations: BM — body mass (g); FA — forearm length (mm); nk — not known; NP — national park
SpeciesCollection1SexFABMLocalityDate2n/FNaLaephotis kirinyaga 2RCJF742♂28.04.0Comoé NP, Ivory Coast27.06.200232/508°45’N, 3°48’WNeoromicia guineensisRCJF717♀30.53.0Comoé NP, Ivory Coast27.06.200226/488°45’N, 3°48’WNycticeinops happoldorumRCJF671♂37.29.0Banco NP, Ivory Coast13.09.200224/445°23’N, 4°03’WN. schlieffeniiRCJF791♂31.04.8Niéguéni, Burkina Faso,23.02.200934/5010°39’N, 5°24’WPseudoromicia brunneaRCJF764♀35.88.0Banco NP, Ivory Coast13.09.200236/505°23’N, 4°03’WP. brunneaNone3♂nknkBanco NP, Ivory Coast–36/505°23’N, 4°03’W
1 — Specimens deposited in Research Collection Jakob Fahr (RCJF)
2 — Species classification based on 99% similarity in RAG2 between specimens from same location as karyotyped specimen and specimen JX276347
from Senegal, see Table 2
3 — Fetus of RCJF764
description: Published as part of Volleth, Marianne, Mayer, Frieder, Heller, Klaus-Gerhard, Müller, Stefan & Fahr, Jakob, 2023, Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe, pp. 37 in Acta Chiropterologica 25 (1) on page 37, DOI: 10.3161/15081109ACC2023.25.1.002, http://zenodo.org/record/10265140
DOI: 10.5281/zenodo.15141265
title: TABLE 2 in Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe

description: TABLE 2. Species identification by mtDNA (cyt b, COI) and RAG2. References (Ref.): 1 — Koubínová et al. (2013); 2 — Monadjem et al. (2021 b); 3 — Decher et al. (2015); 4 — D. Reeder et al. (unpublished); 5 — Hutterer et al. (2019); 6 — Monadjem et al. (2013); 7 — S. D. McCulloch (unpublished); 8 — Monadjem et al. (2021 a)
Specimen examinedBLAST comparisonFinal classificationVoucher1CountryMorphological identificationGeneGenBank No.TaxonGenBank No.SimilarityCountryRef.Laephotis kirinyaga(released)2Ivory CoastNeoromicia somalicaRAG2OQ408330L. kirinyaga 3JX27634799.7Senegal1L. kirinyagaSMF921114MaliN. somalicaRAG2OQ408331L. kirinyagaJX27634799.8Senegal1Neoromicia guineensisRCJF717Ivory CoastN. guineensiscyt bOQ408324N. somalicaMT77797996.0Kenya2COIOQ398480N. cf. somalic aKT59820299.2Guinea3N. cf. guineenisMH98940093.4southern Sudan4Nycticeinops happoldorumRCJF671Ivory CoastN. cf. grandidiericyt bOQ408325N. happoldorumMK188525100Guinea5COIOQ398479N. happoldorumJX508833.199.4Liberia6N. schlieffeniiRCJF791Burkina FasoN. schlieffeniicyt bOQ408326N. schlieffeniiJX27630198.7SenegalCOIOQ398478N. cf. schlieffeniiKF45266188.6Republic ofSouth Africa1Pseudoromicia brunneaRCJF764Ivory CoastP. brunneacyt bOQ408327P. brunneaMT77793999.7Guinea2P. brunneaNone5Ivory CoastP. brunneaCOIOQ398477P. brunneaJX508819100.0Liberia8Nycticeinops macrocephalusSMF794446RwandaN. eisentrauticyt bOQ408328N. eisentrautiMK18852298.4Cameroon5N. crassulusSMF794427DemocraticN. crassuluscyt bOQ408329N. cf. crassulusMT77791398.6Tanzania2Republic ofN. bellieriMK18852187.0Guinea5the Congo
1 — Sampling locality is given in Table 1
2 — Comoe NP, Ivory Coast
3 — Classified as L. capensis by Koubínová et al. (2013), but identified as L. kirinyaga according to sequence similarity by Monadjem et al. (2021 b) 4 — Tombane, Mali: 12°16’N, 8°45’W
5 — Fetus of RCJF764
6 — Nyungwe Forest Reserve near Cyangugu, Rwanda: 02°20’S, 28°54’E (Heller et al., 1994)
7 — Irangi, Kivu province, Democratic Republic of the Congo: 01°54’S, 28°27’E
description: Published as part of Volleth, Marianne, Mayer, Frieder, Heller, Klaus-Gerhard, Müller, Stefan & Fahr, Jakob, 2023, Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe, pp. 38 in Acta Chiropterologica 25 (1) on page 38, DOI: 10.3161/15081109ACC2023.25.1.002, http://zenodo.org/record/10265140
DOI: 10.5281/zenodo.15141266
title: TABLE 2 in Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe

description: TABLE 2. Species identification by mtDNA (cyt b, COI) and RAG2. References (Ref.): 1 — Koubínová et al. (2013); 2 — Monadjem et al. (2021 b); 3 — Decher et al. (2015); 4 — D. Reeder et al. (unpublished); 5 — Hutterer et al. (2019); 6 — Monadjem et al. (2013); 7 — S. D. McCulloch (unpublished); 8 — Monadjem et al. (2021 a)
Specimen examinedBLAST comparisonFinal classificationVoucher1CountryMorphological identificationGeneGenBank No.TaxonGenBank No.SimilarityCountryRef.Laephotis kirinyaga(released)2Ivory CoastNeoromicia somalicaRAG2OQ408330L. kirinyaga 3JX27634799.7Senegal1L. kirinyagaSMF921114MaliN. somalicaRAG2OQ408331L. kirinyagaJX27634799.8Senegal1Neoromicia guineensisRCJF717Ivory CoastN. guineensiscyt bOQ408324N. somalicaMT77797996.0Kenya2COIOQ398480N. cf. somalic aKT59820299.2Guinea3N. cf. guineenisMH98940093.4southern Sudan4Nycticeinops happoldorumRCJF671Ivory CoastN. cf. grandidiericyt bOQ408325N. happoldorumMK188525100Guinea5COIOQ398479N. happoldorumJX508833.199.4Liberia6N. schlieffeniiRCJF791Burkina FasoN. schlieffeniicyt bOQ408326N. schlieffeniiJX27630198.7SenegalCOIOQ398478N. cf. schlieffeniiKF45266188.6Republic ofSouth Africa1Pseudoromicia brunneaRCJF764Ivory CoastP. brunneacyt bOQ408327P. brunneaMT77793999.7Guinea2P. brunneaNone5Ivory CoastP. brunneaCOIOQ398477P. brunneaJX508819100.0Liberia8Nycticeinops macrocephalusSMF794446RwandaN. eisentrauticyt bOQ408328N. eisentrautiMK18852298.4Cameroon5N. crassulusSMF794427DemocraticN. crassuluscyt bOQ408329N. cf. crassulusMT77791398.6Tanzania2Republic ofN. bellieriMK18852187.0Guinea5the Congo
1 — Sampling locality is given in Table 1
2 — Comoe NP, Ivory Coast
3 — Classified as L. capensis by Koubínová et al. (2013), but identified as L. kirinyaga according to sequence similarity by Monadjem et al. (2021 b) 4 — Tombane, Mali: 12°16’N, 8°45’W
5 — Fetus of RCJF764
6 — Nyungwe Forest Reserve near Cyangugu, Rwanda: 02°20’S, 28°54’E (Heller et al., 1994)
7 — Irangi, Kivu province, Democratic Republic of the Congo: 01°54’S, 28°27’E
description: Published as part of Volleth, Marianne, Mayer, Frieder, Heller, Klaus-Gerhard, Müller, Stefan & Fahr, Jakob, 2023, Karyotype comparison of five African Vespertilionini species with comments on phylogenetic relationships and proposal of a new subtribe, pp. 38 in Acta Chiropterologica 25 (1) on page 38, DOI: 10.3161/15081109ACC2023.25.1.002, http://zenodo.org/record/10265140
DOI: 10.5281/zenodo.14664475
title: Constraining Symmetry Energy Slope and Trace Anomaly Based on NICER Observations of PSR J0437-4715 and PSR J1231-1411
DOI: 10.5281/zenodo.14664476
title: Constraining Symmetry Energy Slope and Trace Anomaly Based on NICER Observations of PSR J0437-4715 and PSR J1231-1411
DOI: 10.6084/m9.figshare.28216619
title: Files

description: dataset
DOI: 10.6084/m9.figshare.28216619.v1
title: Files

description: dataset
DOI: 10.15468/dl.8tgq59
title: Occurrence Download

description: A dataset containing 1879 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Phlebotominae de Colombia (Diptera: Psychodidae) en la Colección de Insectos de Importancia Médica del Instituto Nacional de Salud de Colombia"
 ]
}

 The dataset includes 1879 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072120-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mnrtxs
title: Occurrence Download

description: A dataset containing 1552 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((121.49146 18.90336,120.45652 18.59758,119.65678 17.86841,119.51566 15.30456,118.52775 10.88252,116.95181 8.17754,117.65745 7.96584,120.59765 6.20173,122.76163 6.27229,124.26701 5.7313,125.7959 5.0727,126.97198 7.30724,126.57212 9.91813,125.56069 13.18763,123.06741 14.92822,122.57346 18.59758,121.49146 18.90336))"
 ]
}

 The dataset includes 1552 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072121-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28216634
title: Tiemenguan

description: Data published in the journal PLOS ONE.
DOI: 10.6084/m9.figshare.28216634.v1
title: Tiemenguan

description: Data published in the journal PLOS ONE.
DOI: 10.15468/dl.pztqpd
title: Occurrence Download

description: A dataset containing 390 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Engystomops coloradorum (Cannatella & Duellman, 1984)"
 ]
}

 The dataset includes 390 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072122-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fybxz6
title: Occurrence Download

description: A dataset containing 770 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-82.24787 23.35934,-83.18372 23.33943,-84.8563 22.76199,-85.15498 22.00534,-84.31869 21.60711,-83.12399 22.24429,-82.14831 22.48323,-82.32752 21.90579,-81.53105 21.60711,-79.38058 21.02967,-78.54429 19.77523,-74.22344 19.77523,-73.96459 20.53188,-74.92035 20.87038,-75.99559 21.34826,-79.22129 23.14031,-82.24787 23.35934))"
 ]
}

 The dataset includes 770 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072123-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25919/0qc5-my34
title: Parkes observations for project P630 semester 2010OCTS_14

description: We propose to carry out the most ambitious and comprehensive all-sky survey for pulsars and transient sources to date. Using the 20cm multibeam and a new digital filterbank array this survey will create a petabyte digital record of the sky that can be data mined in the future and used to search for relativistic binary and millisecond pulsars, RRATs, and extragalactic radio bursts. The survey should discover 100s of new millisecond and normal pulsars and help define the lower limit to pulsar periods, test theories of relativistic gravity, find transients and provide pulsars for gravitational wave detection.
DOI: 10.25919/c8x6-5b10
title: Parkes observations for project P630 semester 2010OCTS_13

description: We propose to carry out the most ambitious and comprehensive all-sky survey for pulsars and transient sources to date. Using the 20cm multibeam and a new digital filterbank array this survey will create a petabyte digital record of the sky that can be data mined in the future and used to search for relativistic binary and millisecond pulsars, RRATs, and extragalactic radio bursts. The survey should discover 100s of new millisecond and normal pulsars and help define the lower limit to pulsar periods, test theories of relativistic gravity, find transients and provide pulsars for gravitational wave detection.
DOI: 10.25919/m2am-6g59
title: Parkes observations for project P630 semester 2010OCTS_15

description: We propose to carry out the most ambitious and comprehensive all-sky survey for pulsars and transient sources to date. Using the 20cm multibeam and a new digital filterbank array this survey will create a petabyte digital record of the sky that can be data mined in the future and used to search for relativistic binary and millisecond pulsars, RRATs, and extragalactic radio bursts. The survey should discover 100s of new millisecond and normal pulsars and help define the lower limit to pulsar periods, test theories of relativistic gravity, find transients and provide pulsars for gravitational wave detection.
DOI: 10.15468/dl.5qq6d9
title: Occurrence Download

description: A dataset containing 590 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-67.41648 17.82799,-65.71357 17.93882,-65.50794 18.66044,-67.41648 18.66044,-67.41648 17.82799))"
 ]
}

 The dataset includes 590 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072124-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25919/5j3d-vr46
title: Parkes observations for project P630 semester 2010OCTS_12

description: We propose to carry out the most ambitious and comprehensive all-sky survey for pulsars and transient sources to date. Using the 20cm multibeam and a new digital filterbank array this survey will create a petabyte digital record of the sky that can be data mined in the future and used to search for relativistic binary and millisecond pulsars, RRATs, and extragalactic radio bursts. The survey should discover 100s of new millisecond and normal pulsars and help define the lower limit to pulsar periods, test theories of relativistic gravity, find transients and provide pulsars for gravitational wave detection.
DOI: 10.15468/dl.42u8sn
title: Occurrence Download

description: A dataset containing 1502 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Especies del género Anopheles (Diptera: Culicidae) asociadas al domicilio humano en 25 localidades de los municipios de Timbiquí, Guapi y Santa Bárbara ubicadas un área endémica para malaria al suroccidente de Colombia"
 ]
}

 The dataset includes 1502 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072125-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w77fvh
title: Occurrence Download

description: A dataset containing 559 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-71.66545 20.15206,-72.59507 20.36897,-73.47304 20.20371,-73.56601 19.71824,-73.36975 19.491,-73.09087 19.33606,-72.79132 19.06751,-72.38849 18.61303,-73.23547 18.65434,-73.93785 18.94356,-74.6299 18.68533,-74.50595 18.14822,-74.08246 17.79703,-73.40074 17.95197,-72.32651 17.95197,-71.3969 17.31156,-70.75649 18.13789,-68.59772 17.95197,-67.78172 18.49941,-69.04187 19.62528,-71.66545 20.15206))"
 ]
}

 The dataset includes 559 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072126-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.75etzk
title: Occurrence Download

description: A dataset containing 1017 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is USA.16_1",
 "OccurrenceStatus is Present",
 "PublishingOrg is 28eb1a3f-1c15-4a95-931a-4af90ecb574d",
 "TaxonKey is Danaus plexippus (Linnaeus, 1758)"
 ]
}

 The dataset includes 1017 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072129-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vuyb68
title: Occurrence Download

description: A dataset containing 1383 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-78.50975 17.65142,-76.15641 17.65142,-76.15641 18.60456,-78.50975 18.60456,-78.50975 17.65142))"
 ]
}

 The dataset includes 1383 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072130-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qrze9p
title: Occurrence Download

description: A dataset containing 1946 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is USA.37_1",
 "OccurrenceStatus is Present",
 "PublishingOrg is 28eb1a3f-1c15-4a95-931a-4af90ecb574d",
 "TaxonKey is Danaus plexippus (Linnaeus, 1758)"
 ]
}

 The dataset includes 1946 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072131-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.svcda3
title: Occurrence Download

description: A dataset containing 54 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-61.54562 15.17719,-61.20295 15.17719,-61.20295 15.66498,-61.54562 15.66498,-61.54562 15.17719))"
 ]
}

 The dataset includes 54 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072132-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qjyxec
title: Occurrence Download

description: A dataset containing 214 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-61.29032 14.31564,-60.67604 14.31564,-60.67604 14.93386,-61.29032 14.93386,-61.29032 14.31564))"
 ]
}

 The dataset includes 214 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072133-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9fv42u
title: Occurrence Download

description: A dataset containing 33 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Field Museum of Natural History (Botany) Pteridophyte Collection",
 "Geometry POLYGON((-61.93529 16.96449,-61.61254 16.96449,-61.61254 17.23015,-61.93529 17.23015,-61.93529 16.96449))"
 ]
}

 The dataset includes 33 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072134-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pdewre
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Geometry POLYGON((-7.64864 36.82691,-4.75889 36.16317,-4.57677 37.17599,-5.29313 38.30891,-7.34509 38.46119,-7.64864 36.82691))",
 "HasGeospatialIssue is false",
 "TaxonKey is Geranium molle L."
 ]
}

 The dataset includes 92 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072135-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s9d9yy
title: Occurrence Download

description: A dataset containing 122 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Geometry POLYGON((-7.28522 37.05607,-6.4818 35.67121,-3.8361 36.61832,-5.1773 38.504,-6.85876 38.27181,-7.28522 37.05607))",
 "HasGeospatialIssue is false",
 "TaxonKey is Geranium molle L."
 ]
}

 The dataset includes 122 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0072136-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28193990
title: CTDdgv: a comprehensive database for the identification and clinical interpretation of ctDNA driver genes and variants in cancer

description: Circulating tumor DNA (ctDNA) variants hold significant promise as cancer biomarkers in liquid biopsies, owing to their minimally invasive testing approach and capacity to capture the comprehensive tumor landscape. However, a comprehensive resource for studying ctDNA variants is still lacking. Here, we developed CTDdgv, which aims to identify ctDNA variants and interpret their clinical relevance systematically. We manually curated 1674 experimentally validated clinical interpretations for ctDNA variants, concerning prognostic significance, drug resistance, associations with tumor characteristics, metastasis monitoring, therapy guiding, prospect for detection, and others. Furthermore, we developed and integrated a pipeline that identifies tumor driver genes (TDGs) and variants (TDVs) and evaluates the prognostic significance of potential TDGs. Using publicly available ctDNA mutation spectra, we identified potential TDGs and TDVs from 38 datasets across 17 cancer types. Based on these data sets, we provide the multi-dimensional analysis of TDG gene sets in specific cancer types, providing insights into their driving effects. Collectively, CTDdgv has significant potential to serve as a valuable resource for molecular diagnostics and therapeutic decision-making in cancer via liquid biopsy.
DOI: 10.6084/m9.figshare.28193990.v1
title: CTDvic：用于鉴定和临床解释癌症中 ctDNA 驱动基因和变异的综合数据库

description: 循环肿瘤 DNA （ctDNA） 变体因其微创检测方法和捕获综合肿瘤景观的能力而成为液体活检中的癌症生物标志物，具有重要前景。然而，仍然缺乏研究 ctDNA 变体的综合资源。在这里，我们开发了 CTDdgv，旨在识别 ctDNA 变异并系统地解释它们的临床相关性。我们手动整理了 1674 例经过实验验证的 ctDNA 变异临床解释，涉及预后意义、耐药性、与肿瘤特征的关联、转移监测、治疗指导、检测前景等。此外，我们开发并集成了一个管道，用于识别肿瘤驱动基因 （TDG） 和变异 （TDV） 并评估潜在 TDG 的预后意义。使用公开可用的 ctDNA 突变谱，我们从 17 种癌症类型的 38 个数据集中确定了潜在的 TDG 和 TDV。基于这些数据集，我们提供了特定癌症类型中 TDG 基因集的多维分析，从而深入了解其驱动效应。总的来说，CTDdgv 具有巨大的潜力，可以作为 ctDNA 变体的分子诊断和治疗决策的宝贵资源。