cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24218751.v1
title: Supplementary Material for: Lung hypoplasia in Fetuses with Skeletal Dysplasia Determined by Fetal Lung Weight. Which Ultrasound Measurement/Ratio Has the Highest Detection Rate

description: Introduction To determine lung hypoplasia in cases with fetal skeletal dysplasia based on the total lung weight at autopsy as the most accountable surrogate marker for pulmonary hypoplasia. Methods This retrospective cohort study included all pregnancies with antenatal diagnosis of skeletal dysplasia(2012-2018). We included only cases in which information on fetal biometry was available within 2 weeks before delivery and had autopsy and skeletal X-rays+molecular analysis using extracted fetal DNA. We compared the predictive accuracy of fetal sonographic body-proportional ratios including:(1) thoracic circumference-to-abdominal circumference(TC/AC) ratio, (2)the femur length-to-abdominal circumference(FL/AC) ratio, (3)head circumference-to-abdominal circumference(HC/AC) ratio, and (4)foot length-to-femur length ratio. Lung hypoplasia was defined as total lung weight below -2SD from the expected mean for gestational age. Results 53 pregnancies with antenatal diagnosis of skeletal dysplasia underwent autopsy included. Lung hypoplasia was determined in 34(64.1%). Median of gestational age at last sonographic assessment was 21.3(19.9-24.9) weeks. FL/AC ratio demonstrated the highest area under the curve of 0.817(95%CI:0.685-0.949;p&lt;0.0001). FL/AC≤0.1550 demonstrated the highest detection rate of 88.2% along with the highest negative predictive value(NPV) of 75%. Discussion/Conclusion Using a novel, more practical approach to predict lung hypoplasia in skeletal dysplasia, fetal sonographic body-proportional ratios and, specifically, FL/AC ratio demonstrate a high detection rate of lung hypoplasia.
DOI: 10.3886/e194890v1
title: Health About How To Ease Sleep Apnea Symptoms

description: Sleep apnea is caused by partial or complete blockage of the airway during sleep. There are two main types - obstructive sleep apnea and central sleep apnea. <br><br>Obstructive sleep apnea (OSA) is the most common type and is caused when the muscles supporting the soft palate and throat relax too much during sleep. This blocks the airway and reduces or stops airflow despite breathing efforts. Fat deposits around the upper airway and structural problems like a large neck circumference or enlarged tonsils can also cause OSA. <br>Central sleep apnea is less common and occurs when the brain fails to signal the breathing muscles to contract regularly. <br>Sleep apnea is a serious condition because the frequent interruptions to breathing and reductions in blood oxygen levels disturb deep sleep cycles. Over many years, this lack of quality rest makes it a major risk factor for serious health problems like heart disease, stroke, diabetes and depression. <br>People with untreated severe apnea are up to twice as likely to die prematurely from related issues. It also increases the risk of traffic and workplace accidents due to excessive daytime sleepiness. Loud snoring and choking noises during episodes can disturb partners' sleep as well. <br>In summary, sleep apnea causes fragmented sleep and low oxygen levels which tax the cardiovascular system over time. It represents a very real and potentially life-threatening condition if not properly diagnosed and treated.
DOI: 10.5281/zenodo.10051597
title: Data and codes for figures in "Open water in sea ice causes high bias in polar low-level clouds in GFDL CM4"
DOI: 10.6084/m9.figshare.24210537
title: Supplementary Material for: Olfactory bulbs in arthritis model mouse persistently express interleukin-6 before the onset of arthritis: Relationship to food intake

description: Introduction Rheumatoid arthritis (RA) can be comorbid with psychiatric symptoms. Brain abnormalities in RA patients and in arthritis models have been reported. However, it remains unclear when these abnormalities occur and where they are distributed. In this study, we analyzed spatiotemporal changes in gene expression in the brains of mice with collagen-induced arthritis (CIA). Methods Mice were divided into three groups: i) CIA (all mice developed arthritis on day 35): complete Freund’s adjuvant (CFA) and type II collagen at initial immunization, and incomplete Freund’s adjuvant (IFA) and type II collagen at booster immunization; ii) C(+/-) (50% mice developed arthritis on day 35): only IFA at booster immunization; and iii) C(-/-) (no arthritis): only CFA at initial immunization and only IFA at booster immunization. Whole brains were collected at ten stages of arthritis and divided into six sections. Real-time polymerase chain reaction was performed using RNA extracted from the brain, and the expression of proinflammatory cytokines and glial markers was semi-quantified. Arthritis score, body weight, and food and water intakes were recorded and analyzed for correlations with brain gene expression. We also investigated the effect of interleukin-6 (IL-6) injection in the olfactory bulbs (OB) on the food intake. Results After booster immunization, a transient increase in integrin subunit α-M and IL-1β was observed in multiple areas in CIA. IL-6 is persistently expressed in the OB before the onset of arthritis, which is correlated with body weight loss and decreased food intake. This change in the OB was observed in the C(+/-) but not in the C(-/-) group. In the C(+/-) group, non-arthritic mice showed the same changes in the OB as the arthritic mice. This elevation in IL-6 levels persisted throughout the chronic phase until day 84. In addition, IL-6 injection into the OB reduced food intake. Conclusion Persistent elevation of IL-6 in the OB from the early stage of arthritis may be an important finding that might explain the neuropsychiatric pathophysiology of RA, including appetite loss, which is present in the early stages of the disease and manifests as a variety of symptoms over time.
DOI: 10.6084/m9.figshare.24314545
title: Supplementary Material for: Nomenclature of extracorporeal blood purification therapies for acute indications – The Nomenclature Standardization Conference

description: The development of new extracorporeal blood purification (EBP) techniques has led to increased application in clinical practice but also inconsistencies in nomenclature and misunderstanding. In November 2022, an international consensus conference was held to establish consensus on the terminology of EBP therapies. It was agreed to define EBP therapies as techniques that use an extracorporeal circuit to remove and/or modulate circulating substances to achieve physiological homeostasis, including support of the function of specific organs and/or detoxification. Specific acute EBP techniques include renal replacement therapy, isolated ultrafiltration, hemoadsorption and plasma therapies, all of which can be applied in isolation and combination. This paper summarises the proposed nomenclature of EBP therapies and serves as a framework for clinical practice and future research.
DOI: 10.5281/zenodo.8393036
title: Cultures of Suntanning in late-19th to mid-20th century Britain

description: Data collected in the project "Cultures of Suntanning in late 19th to mid-20th century Britain", British Academy Mid-Career Fellowship award number MCFSS22\220038.
Archive Dataset lists identifying details for all archive resources that were consulted during the project, with a note as to whether data was collected from each source.
Literary dataset lists identifying details for all literary resources consulted during the project, including digital concordances where used, with a note as to whether data was collected from each source.
The raw data collected cannot be made open access due to archive/copyright restrictions. The identifying details provide enough supplementary information for researchers to locate these resources.
DOI: 10.5281/zenodo.8393035
title: Cultures of Suntanning in late-19th to mid-20th century Britain

description: Data collected in the project "Cultures of Suntanning in late 19th to mid-20th century Britain", British Academy Mid-Career Fellowship award number MCFSS22\220038.
Archive Dataset lists identifying details for all archive resources that were consulted during the project, with a note as to whether data was collected from each source.
Literary dataset lists identifying details for all literary resources consulted during the project, including digital concordances where used, with a note as to whether data was collected from each source.
The raw data collected cannot be made open access due to archive/copyright restrictions. The identifying details provide enough supplementary information for researchers to locate these resources.
DOI: 10.25318/9810039901-eng
title: Employment income statistics by visible minority, immigrant status, highest level of education and location of study: Canada, provinces and territories

description: Employment income of visible minority groups by educational characteristics, including location of study.
DOI: 10.6084/m9.figshare.24198684
title: Supplementary Material for: Effects of cell-adhesive ligand presentation on pentapeptide supramolecular assembly and gelation: Simulations and Experiments

description: The extracellular matrix (ECM) is a complex, hierarchical material containing structural and bioactive components. This complexity makes decoupling the effects of biomechanical properties and cell-matrix interactions difficult, especially when studying cellular processes in a 3D environment. Matrix mechanics and cell adhesion are both known regulators of specific cellular processes such as stem cell proliferation and differentiation. However, more information is required about how such variables impact various neural lineages that could, upon transplantation, therapeutically improve neural function after central nervous system (CNS) injury or disease. Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) hydrogels are one biomaterial approach to meet these goals, consisting of a family of peptide sequences that assemble into physical hydrogels in physiological media. In this study, we studied our previously reported supramolecularly-assembling RAPID hydrogels functionalized with the ECM-derived cell adhesive peptide ligands RGD, IKVAV, and YIGSR. Using molecular dynamics simulations and experimental rheology we demonstrated that these integrin-binding ligands at physiological concentrations (3-12 mM) did not impact assembly of the KYFIL peptide system. In simulations, molecular measures of assembly such as hydrogen bonding and pi-pi interactions appeared unaffected by cell-adhesion sequence or concentration. Visualizations of clustering and analysis of solvent accessible surface area (SASA) indicated that the integrin-binding domains remained exposed. KYFIL or AYFIL hydrogels containing 3 mM of integrin-binding domains resulted in mechanical properties consistent with their non-functionalized equivalents. This strategy of doping RAPID gels with cell-adhesion sequences allows for the precise tuning of peptide ligand concentration, independent of the rheological properties. The controllability of the RAPID hydrogel system provides an opportunity to investigate the effect of integrin-binding interactions on encapsulated neural cells to discern how hydrogel microenvironment impacts growth, maturation, or differentiation.
DOI: 10.6084/m9.figshare.24198684.v1
title: Supplementary Material for: Effects of cell-adhesive ligand presentation on pentapeptide supramolecular assembly and gelation: Simulations and Experiments

description: The extracellular matrix (ECM) is a complex, hierarchical material containing structural and bioactive components. This complexity makes decoupling the effects of biomechanical properties and cell-matrix interactions difficult, especially when studying cellular processes in a 3D environment. Matrix mechanics and cell adhesion are both known regulators of specific cellular processes such as stem cell proliferation and differentiation. However, more information is required about how such variables impact various neural lineages that could, upon transplantation, therapeutically improve neural function after central nervous system (CNS) injury or disease. Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) hydrogels are one biomaterial approach to meet these goals, consisting of a family of peptide sequences that assemble into physical hydrogels in physiological media. In this study, we studied our previously reported supramolecularly-assembling RAPID hydrogels functionalized with the ECM-derived cell adhesive peptide ligands RGD, IKVAV, and YIGSR. Using molecular dynamics simulations and experimental rheology we demonstrated that these integrin-binding ligands at physiological concentrations (3-12 mM) did not impact assembly of the KYFIL peptide system. In simulations, molecular measures of assembly such as hydrogen bonding and pi-pi interactions appeared unaffected by cell-adhesion sequence or concentration. Visualizations of clustering and analysis of solvent accessible surface area (SASA) indicated that the integrin-binding domains remained exposed. KYFIL or AYFIL hydrogels containing 3 mM of integrin-binding domains resulted in mechanical properties consistent with their non-functionalized equivalents. This strategy of doping RAPID gels with cell-adhesion sequences allows for the precise tuning of peptide ligand concentration, independent of the rheological properties. The controllability of the RAPID hydrogel system provides an opportunity to investigate the effect of integrin-binding interactions on encapsulated neural cells to discern how hydrogel microenvironment impacts growth, maturation, or differentiation.
DOI: 10.34808/qpv7-d759
title: Case Study NEB Atlas / part I - 3D Models / Brunnshög, Lund

description: The data presents the results of work on the analysis of contemporary neighbourhoods. The aim of this part of the research was to create a digital model - a simplified digital twin - for selected parts of housing estates already realised in various cities in Europe. This group presents a model for a fragment of the Brunnshög district in Lund, Sweden. The students made digital models based on the analysis of web-based data. On this basis, they reconstructed the structure by analysing the layout and heights of the buildings and the shape of the roofs.
The dataset presents the design work of students at the Faculty of Architecture, Gdansk University of Technology, first semester of their master's studies. The research work was coordinated by Justyna Martyniuk-Pęczek, PhD., D.Sc., Architect and was realised within the framework of a research grant entitled "Study of the potential of residential district structures in the context of the search for initiatives. "Investigating the potential of structures of residential neighbourhoods in the context of the search for urban planning initiatives for sustainable development" as part of the implementation of the TECHNETIUM TALENT MANAGEMENT GRANTS programme - Programme type: Mentoring Grants Programme: Technetium Talent Management Grants, Application Number: 23/1/2022/IDUB/III.4c/Tc at the EcoTech Centre.
The results in the dataset provide a basis for further research and development of the topic of shaping residential neighbourhoods.
DOI: 10.34808/3bv8-mv19
title: Case Study NEB Atlas / part I - 3D Models / King's Cross, London

description: The data presents the results of work on the analysis of contemporary neighbourhoods. The aim of this part of the research was to create a digital model - a simplified digital twin - for selected parts of housing estates already realised in various cities in Europe. This group presents a model for a fragment of the King's Cross, London, UK. The students made digital models based on the analysis of web-based data. On this basis, they reconstructed the structure by analysing the layout and heights of the buildings and the shape of the roofs.
The dataset presents the design work of students at the Faculty of Architecture, Gdansk University of Technology, first semester of their master's studies. The research work was coordinated by Justyna Martyniuk-Pęczek, PhD., D.Sc., Architect and was realised within the framework of a research grant entitled "Study of the potential of residential district structures in the context of the search for initiatives for sustainable development" as part of the implementation of the TECHNETIUM TALENT MANAGEMENT GRANTS programme - Programme type: Mentoring Grants Programme: Technetium Talent Management Grants, Application Number: 23/1/2022/IDUB/III.4c/Tc at the EcoTech Centre.
The results in the dataset provide a basis for further research and development of the topic of shaping residential neighbourhoods.
DOI: 10.21942/uva.24476764
title: Data set belonging to Bij de Vaate et al. (2023). Social media self-effects on adolescents' self-esteem: A 100-day diary study

description: This data set belongs to: Bij de Vaate, N. A. J. D., Valkenburg, P. M., Janssen, L. H. C., van der Wal, A., Keijsers, L., & Beyens, I. (2023). Social media self-effects on adolescents' self-esteem: A 100-day dairy study. <br> More information about the study is available on the Open Science Framework (OSF), including the preregistration of the study (https://osf.io/nrygd), and analyses and output materials (https://osf.io/umkt9/). <br> For more information, please contact the authors at a.j.d.bijdevaate@uva.nl or info@project-awesome.nl.
DOI: 10.21942/uva.24476764.v1
title: Data set belonging to Bij de Vaate et al. (2023). Social media self-effects on adolescents' self-esteem: A 100-day diary study

description: This data set belongs to: Bij de Vaate, N. A. J. D., Valkenburg, P. M., Janssen, L. H. C., van der Wal, A., Keijsers, L., & Beyens, I. (2023). Social media self-effects on adolescents' self-esteem: A 100-day dairy study. <br> More information about the study is available on the Open Science Framework (OSF), including the preregistration of the study (https://osf.io/nrygd), and analyses and output materials (https://osf.io/umkt9/). <br> For more information, please contact the authors at a.j.d.bijdevaate@uva.nl or info@project-awesome.nl.
DOI: 10.6084/m9.figshare.24473932
title: Supplementary Material for: Oral chronic graft-versus-host disease (cGVHD) in post-hematopoietic stem cell transplant (post-HCT) patients following SARS-CoV-2 vaccination: Case reports

description: Patients receiving allogeneic hematopoietic stem cell transplant (HCT) may experience graft-versus-host disease (GVHD) in which donor immune cells cause an immune reaction in host tissues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines are highly effective in prevention of severe Coronavirus-2019 (COVID-19) disease, but the vaccine can result in immune activation and GVHD. Herein we report four cases of oral manifestations that may have been stimulated by COVID-19 or vaccination with Pfizer or Moderna vaccines. We believe this study is the first to report oral changes driven by an inflammatory/immune mechanism leading to oral symptomatic cGVHD. The clinical impact of this study is early recognition and appropriate management of oral symptomatic cGVHD following COVID-19 disease or SARS-CoV-2 vaccination.
DOI: 10.6084/m9.figshare.24473932.v1
title: Supplementary Material for: Oral chronic graft-versus-host disease (cGVHD) in post-hematopoietic stem cell transplant (post-HCT) patients following SARS-CoV-2 vaccination: Case reports

description: Patients receiving allogeneic hematopoietic stem cell transplant (HCT) may experience graft-versus-host disease (GVHD) in which donor immune cells cause an immune reaction in host tissues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines are highly effective in prevention of severe Coronavirus-2019 (COVID-19) disease, but the vaccine can result in immune activation and GVHD. Herein we report four cases of oral manifestations that may have been stimulated by COVID-19 or vaccination with Pfizer or Moderna vaccines. We believe this study is the first to report oral changes driven by an inflammatory/immune mechanism leading to oral symptomatic cGVHD. The clinical impact of this study is early recognition and appropriate management of oral symptomatic cGVHD following COVID-19 disease or SARS-CoV-2 vaccination.
DOI: 10.6084/m9.figshare.24310354
title: Supplementary Material for: SAFETY AND EFFICACY OF ATEZOLIZUMAB/ BEVACIZUMAB IN PATIENTS WITH HEPATOCELLULAR CARCINOMA AND IMPAIRED LIVER FUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS

description: BACKGROUND: Safety and outcome of atezolizumab/bevacizumab in Child-Pugh B patients with hepatocellular carcinoma (HCC) have not been completely characterized. OBJECTIVES: In this study we aimed at addressing safety and efficacy of atezolizumab/bevacizumab in Child-Pugh B patients by reviewing the available data and analysing them by meta-analysis. METHOD: We compared the safety and efficacy of atezolizumab/becavizumab treatment in patients with unresectable HCC and various degrees of liver dysfunction. A total of 8 retrospective, non-randomized, cohort studies were included in this meta-analysis, for a total of 1,071 Child-Pugh A and 225 Child-Pugh B patients. The albumin-bilirubin (ALBI) grade was also used to assess liver function, when available. RESULTS: Grade ≥3 adverse events were observed in 11.8% of Child-Pugh class A and 26.8% class B patients (P=0.0001), with an Odds Ratio (OR) of 0.43 [confidence interval (CI) 0.21–0.90; P=0.02). Progression Free Survival (PFS) at both 6-month (4.90±2.08 vs 4.75±2.08 months; P=0.0004) and 12-month (8.83±2.32 vs 7.26±2.33 months; P=0.002) was lower in Child-Pugh class B patients. A trend towards higher objective response rate (ORR) was observed in Child-Pugh class A patients (219/856, 25.6%) as compared to Child-Pugh class B patients (25/138, 18.1%; P=0.070), while the probability of obtaining an ORR was significantly greater in Child-Pugh A patients (OR 1.79, CI 1.12–2.86; P=0.02). Median overall survival (OS) was 16.8±2.0 and 6.8±3.2 months in Child-Pugh A and B patients, respectively (mean difference 9.06 months, CI 7.01–11.1, P&lt;0.0001). Lastly, OS was longer in patients with ALBI grade 1-2 than in those with grade 3 (8.3±11.4 versus 3.3±5.0 months, P=0.0008). CONCLUSIONS: Oncological efficacy of atezolizumab/bevacizumab is moderate in Child-Pugh class B patients, and the shorter PFS and OS associated with the greater likelihood of experiencing treatment-related adverse events observed in these patients suggest great caution and individualization of treatment, possibly with the support of the ALBI grade.