cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.25621620
title: Supporting data for "Identifying genetic vulnerabilities in patient-derived gastric cancer organoids by CRISPR-Cas9 screening"

description: Identifying vulnerabilities for the many tumor subtypes to devise precision treatment strategies remains a challenging task. CRISPR screens facilitate the discovery of cancer vulnerabilities that can be exploited therapeutically, but screening has been limited to two-dimensional (2D) monolayer cell line culture that does not recapitulate <i>in vivo</i> environment. Here we establish the CRISPR dropout screening pipeline in patient-derived gastric cancer organoids. Our organoid-based CRISPR subpool library screens uncover common and differential vulnerabilities in a panel of organoids derived from patients with distinct gastric cancer subtypes. We then extend the CRISPR dropout screening to a genome-wide scale and exemplify organoid-dependent vulnerabilities with metabolic regulators as prioritized targets that are not revealed when using 2D and even three-dimensional (3D) spheroid cultures of cell lines. We further demonstrate the <i>in vivo</i> relevance of metabolic vulnerability identified using tumor organoids. Together, our work underscores the power of utilizing organoid-based CRISPR dropout screening for revealing more clinically relevant vulnerabilities, paving way to the development of precision therapeutic treatments.
DOI: 10.25442/hku.25621620.v1
title: Supporting data for "Identifying genetic vulnerabilities in patient-derived gastric cancer organoids by CRISPR-Cas9 screening"

description: Identifying vulnerabilities for the many tumor subtypes to devise precision treatment strategies remains a challenging task. CRISPR screens facilitate the discovery of cancer vulnerabilities that can be exploited therapeutically, but screening has been limited to two-dimensional (2D) monolayer cell line culture that does not recapitulate <i>in vivo</i> environment. Here we establish the CRISPR dropout screening pipeline in patient-derived gastric cancer organoids. Our organoid-based CRISPR subpool library screens uncover common and differential vulnerabilities in a panel of organoids derived from patients with distinct gastric cancer subtypes. We then extend the CRISPR dropout screening to a genome-wide scale and exemplify organoid-dependent vulnerabilities with metabolic regulators as prioritized targets that are not revealed when using 2D and even three-dimensional (3D) spheroid cultures of cell lines. We further demonstrate the <i>in vivo</i> relevance of metabolic vulnerability identified using tumor organoids. Together, our work underscores the power of utilizing organoid-based CRISPR dropout screening for revealing more clinically relevant vulnerabilities, paving way to the development of precision therapeutic treatments.
DOI: 10.25549/whit-c170-95446
title: Characters in play for program, Southern California, 1940

description: 5 photographs of characters in a play, Southern California, 1940. "Subject: Characters in Play for Program; Client: Pilgrimage Play, Lloyd Mitchell; Classifications: see 8x10; Original Print Order: Mon[day] A.M. 2 ea[ch]; Size: 8x10; Finish: gl[ossy]; Re-Order: 1 #3; Year: 1940; Job: 06-28-174" -- on envelope front. "Operator's Report-Name: Herb; 5 Original Photographs-At Studio: 8x10; Print Retouching: For Homer Smith at L[os] A[ngeles] Times; Amount: 25.00, 6.00" -- on envelope back.
DOI: 10.15468/dl.rlguuh
title: Occurrence Download

description: A dataset containing 109136668 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "BasisOfRecord is Specimen"
 ]
}

 The dataset includes 109136668 records from 2669 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000180-150805223722583/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111288616
title: Jerusalem Stele, HITBP Jslm 23

description: [Text Description:] Monument fragment from the Ophel ❧ [Text or Publication Number Note:] HITBP Jslm 23, IAA 1987-1060 ❧ [Excavation Description:] Found in debris of Byzantine building in south of Temple Mount in 1987 ❧ [Medium:] Stone ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Monument fragment, broken on all four sides, 27 x 24 x 10 cm. ❧ [Physical Object Note:] Four lines of text ❧
DOI: 10.15468/dl.5udkba
title: Occurrence Download

description: A dataset containing 493 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Styloceras Kunth ex Juss."
 ]
}

 The dataset includes 493 records from 50 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0201938-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111288568
title: Jerusalem Stele, HITBP Jslm 23

description: [Text Description:] Monument fragment from the Ophel ❧ [Text or Publication Number Note:] HITBP Jslm 23, IAA 1987-1060 ❧ [Excavation Description:] Found in debris of Byzantine building in south of Temple Mount in 1987 ❧ [Medium:] Stone ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Monument fragment, broken on all four sides, 27 x 24 x 10 cm. ❧ [Physical Object Note:] Four lines of text ❧
DOI: 10.15468/dl.jes437
title: Occurrence Download

description: A dataset containing 1127193 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Repatriated is TRUE",
 "Country is Norway"
 ]
}

 The dataset includes 1127193 records from 1230 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0172499-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111288524
title: Jerusalem Stele, HITBP Jslm 23

description: [Text Description:] Monument fragment from the Ophel ❧ [Text or Publication Number Note:] HITBP Jslm 23, IAA 1987-1060 ❧ [Excavation Description:] Found in debris of Byzantine building in south of Temple Mount in 1987 ❧ [Medium:] Stone ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Monument fragment, broken on all four sides, 27 x 24 x 10 cm. ❧ [Physical Object Note:] Four lines of text ❧
DOI: 10.15468/dl.gvjg6w
title: Occurrence Download

description: A dataset containing 580 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cephalocereus Pfeiff."
 ]
}

 The dataset includes 580 records from 55 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0201957-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111288570
title: Jerusalem Stele, HITBP Jslm 23

description: [Text Description:] Monument fragment from the Ophel ❧ [Text or Publication Number Note:] HITBP Jslm 23, IAA 1987-1060 ❧ [Excavation Description:] Found in debris of Byzantine building in south of Temple Mount in 1987 ❧ [Medium:] Stone ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Monument fragment, broken on all four sides, 27 x 24 x 10 cm. ❧ [Physical Object Note:] Four lines of text ❧
DOI: 10.25549/inscriptifact-ouc111123293
title: Votive, cone, UT 1599-25

description: [Text Description:] Votive, cone-shaped temple offering. ❧ [Text or Publication Number Note:] UT 1599-25 ❧ [Excavation Description:] Nisin ❧ [Medium:] Clay ❧ [Script Note:] Cuneiform, Non-Alphabetic ❧ [Physical Object Description:] Clay cone, pink-orange color, fairly uniform. Larger of two cones. LABEL: "1599" in black ink, "25" in red ink. 10.5cm. ❧ [Physical Object Note:] C.J. Gadd, Early Dynasties of Sumer and Akkad (London, 1921), plate 3.
DOI: 10.15468/dl.kuwkmn
title: Occurrence Download

description: A dataset containing 168 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Magnoliopsida, Liliopsida)",
 "BasisOfRecord is one of (Specimen, Human Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2000",
 "Geometry MULTIPOLYGON (((66.0621 56.2, 67.26509 56.39012, 66.74272 56.64066, 65.65405 56.58895, 65.51564 56.38871, 66.0621 56.2)))"
 ]
}

 The dataset includes 168 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0177509-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111290279
title: Gibeon Jar Handle 47, Gibeon Jar Handle 47

description: [Text Description:] hnnyhw nr' ❧ [Text or Publication Number Note:] Gibeon Jar Handle 47; AHI 22.047 ❧ [Excavation Description:] Found at el-Jib (Gibeon) in excavations led by J. B. Pritchard in 1956-57 ❧ [Medium:] Clay ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Jar handle, 5.8-6.5 cm; gray ❧ [Physical Object Note:] Deeply incised, crudely written; hw written below yod; nun omitted, r' crowded into remaining space above. ❧
DOI: 10.15468/dl.k4yfqj
title: Occurrence Download

description: A dataset containing 11729 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Specimen"
 ]
 },
 "TaxonKey is Chortophaga viridifasciata (De Geer, 1773)"
 ]
}

 The dataset includes 11729 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0205409-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111356677
title: Inscription on label, KTU 6.29

description: [Text Description:] Ugaritic Tablet KTU 6.29 ❧ [Text or Publication Number Note:] KTU 6.29; KTU2 6.29; KTU3 6.29; CTU 6.29; CAT 6.29; RS 17.364; DO 4702 ❧ [Excavation Description:] Found during excavations at Ras Shamra. ❧ [Medium:] Clay ❧ [Script Note:] Alphabetic Cuneiform
DOI: 10.25549/inscriptifact-ouc111356771
title: Inscription on label, KTU 6.29

description: [Text Description:] Ugaritic Tablet KTU 6.29 ❧ [Text or Publication Number Note:] KTU 6.29; KTU2 6.29; KTU3 6.29; CTU 6.29; CAT 6.29; RS 17.364; DO 4702 ❧ [Excavation Description:] Found during excavations at Ras Shamra. ❧ [Medium:] Clay ❧ [Script Note:] Alphabetic Cuneiform
DOI: 10.15468/dl.eww5tv
title: Occurrence Download

description: A dataset containing 1233 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Brasiliopuntia (K.Schum.) A.Berger"
 ]
}

 The dataset includes 1233 records from 141 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0201954-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/inscriptifact-ouc111290321
title: Gibeon Jar Handle 54, Gibeon Jar Handle 54

description: [Text Description:] gb'n.gdr … ❧ [Text or Publication Number Note:] Gibeon Jar Handle 54; AHI 22.054 ❧ [Excavation Description:] Found at el-Jib (Gibeon) in excavations led by J. B. Pritchard in 1956-57 ❧ [Medium:] Clay ❧ [Script Note:] Hebrew ❧ [Physical Object Description:] Jar handle, 6.6-7.3 cm; pink ❧ [Physical Object Note:] Heavy marks across middle made accidentally before firing. Vertical stroke of dalet is longer than that of resh. ❧
DOI: 10.15468/dl.xnmca8
title: Occurrence Download

description: A dataset containing 6894785 species occurrences available in GBIF matching the query:
{
 "Country" : [
 "is Peru"
 ]
}

 The dataset includes 6894785 records from 2094 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0201948-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hybvay
title: Occurrence Download

description: A dataset containing 160 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Specimen, Fossil, Living Specimen, Occurrence evidence)",
 "Geometry POLYGON((124.2739 -39.54278,150.20082 -44.70362,160.31942 -20.9762,141.68735 -6.58289,126.46283 -24.15072,124.2739 -39.54278))",
 "HasGeospatialIssue is false",
 "TaxonKey is Beilschmiedia castrisinensis B.Hyland"
 ]
}

 The dataset includes 160 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024217-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k2v894
title: Occurrence Download

description: A dataset containing 5904 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tapirus terrestris (Linnaeus, 1758)"
 ]
}

 The dataset includes 5904 records from 101 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0201159-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nhe6jx
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Allotraeus pallidipennis Ohbayashi, 1958",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0217579-220831081235567/datasets/export for details.
DOI: 10.15468/dl.knq60k
title: Occurrence Download

description: A dataset containing 829 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Canis adustus Sundevall, 1847"
 ]
}

 The dataset includes 829 records from 41 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033386-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pp4s62
title: Occurrence Download

description: A dataset containing 24 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ajuga leucantha Lukhoba"
 ]
}

 The dataset includes 24 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024156-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5nugsz
title: Occurrence Download

description: A dataset containing 321 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((6.75453 51.3089,6.81358 51.27457,6.91246 51.29654,7.05116 51.32538,7.20222 51.34872,7.41783 51.38443,7.47414 51.46133,7.43843 51.58356,7.36702 51.62613,7.27501 51.60965,7.25029 51.59729,7.17613 51.55334,7.03056 51.51489,6.90422 51.48743,6.77513 51.45859,6.6378 51.41739,6.67625 51.29379,6.75453 51.3089))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Plantae",
 "Year 2015-2020"
 ]
}

 The dataset includes 321 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0136830-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wz199x
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Senecio xerophilus var. xerophilus"
 ]
}

 The dataset includes 21 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033386-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eqq8qh
title: Occurrence Download

description: A dataset containing 122 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Oriolus mellianus Stresemann, 1922"
 ]
}

 The dataset includes 122 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004099-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5p96qg
title: Occurrence Download

description: A dataset containing 91 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Mexico",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Crotalus pyrrhus (Cope, 1866)"
 ]
}

 The dataset includes 91 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0147862-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bgyqhc
title: Occurrence Download

description: A dataset containing 40967336 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "TaxonKey is Amphibia",
 "TaxonKey is Aves",
 "TaxonKey is Reptilia",
 "TaxonKey is Mammalia"
 ]
 },
 {
 "or" : [
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Observation",
 "BasisOfRecord is Machine Observation"
 ]
 },
 "Continent is Africa",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2018"
 ]
}

 The dataset includes 40967336 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0033388-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fgv8ma
title: Occurrence Download

description: A dataset containing 1098 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ajuga lupulina Maxim."
 ]
}

 The dataset includes 1098 records from 40 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024160-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m3tgu9
title: Occurrence Download

description: A dataset containing 5591484 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Continent is one of (South America, North America)",
 "Sex is Female"
 ]
}

 The dataset includes 5591484 records from 1488 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024216-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/webster-c100-40623
title: Webster scope

description: A report that assesses the 1992 riots using a wide variety of socioeconomic indicators. PART OF SERIES: In addition to analyzing the 1992 riots as a whole, the Webster Commission also divided into several smaller task forces and study groups, each of which addressed one specific aspect of the civil disturbance. The series consists of reports and appendices produced by five of these groups: the Chronology Team, the Public Officials and Community Team, the LAPD Team, the Comparisons Study Group, and the Inter-Agency Team. Also included are two copies of Webster Scope, a report that interprets the riots and their cumulative effects primarily through graphs, charts, statistics, and figures, and several research memoranda that discuss the legality of several riot-response tactics.
DOI: 10.25549/webster-c100-44262
title: Manual of the Los Angeles Police Department, 1992

description: The Los Angeles Police Department's departmental manual, 1992. PART OF SERIES: The series includes materials related to the performance of the LAPD prior to and during the 1992 Los Angeles riots. Included are reports and documents pertaining to the department's tactical planning measures for unusual occurrences and emergencies; riot-related statistics and figures; and arrest logs, incident logs, and activities reports maintained during the riots.
DOI: 10.25549/webster-c100-44261
title: Manual of the Los Angeles Police Department, 1992

description: The Los Angeles Police Department's departmental manual, 1992. PART OF SERIES: The series includes materials related to the performance of the LAPD prior to and during the 1992 Los Angeles riots. Included are reports and documents pertaining to the department's tactical planning measures for unusual occurrences and emergencies; riot-related statistics and figures; and arrest logs, incident logs, and activities reports maintained during the riots.
DOI: 10.25549/webster-c100-44405
title: Manual of the Los Angeles Police Department, 1992

description: The Los Angeles Police Department's departmental manual, 1992. PART OF SERIES: The series includes materials related to the performance of the LAPD prior to and during the 1992 Los Angeles riots. Included are reports and documents pertaining to the department's tactical planning measures for unusual occurrences and emergencies; riot-related statistics and figures; and arrest logs, incident logs, and activities reports maintained during the riots.
DOI: 10.25549/webster-c100-40642
title: Webster scope

description: A report that assesses the 1992 riots using a wide variety of socioeconomic indicators. PART OF SERIES: In addition to analyzing the 1992 riots as a whole, the Webster Commission also divided into several smaller task forces and study groups, each of which addressed one specific aspect of the civil disturbance. The series consists of reports and appendices produced by five of these groups: the Chronology Team, the Public Officials and Community Team, the LAPD Team, the Comparisons Study Group, and the Inter-Agency Team. Also included are two copies of Webster Scope, a report that interprets the riots and their cumulative effects primarily through graphs, charts, statistics, and figures, and several research memoranda that discuss the legality of several riot-response tactics.
DOI: 10.25549/webster-c100-44371
title: Manual of the Los Angeles Police Department, 1992

description: The Los Angeles Police Department's departmental manual, 1992. PART OF SERIES: The series includes materials related to the performance of the LAPD prior to and during the 1992 Los Angeles riots. Included are reports and documents pertaining to the department's tactical planning measures for unusual occurrences and emergencies; riot-related statistics and figures; and arrest logs, incident logs, and activities reports maintained during the riots.
DOI: 10.25549/webster-c100-40633
title: Webster scope

description: A report that assesses the 1992 riots using a wide variety of socioeconomic indicators. PART OF SERIES: In addition to analyzing the 1992 riots as a whole, the Webster Commission also divided into several smaller task forces and study groups, each of which addressed one specific aspect of the civil disturbance. The series consists of reports and appendices produced by five of these groups: the Chronology Team, the Public Officials and Community Team, the LAPD Team, the Comparisons Study Group, and the Inter-Agency Team. Also included are two copies of Webster Scope, a report that interprets the riots and their cumulative effects primarily through graphs, charts, statistics, and figures, and several research memoranda that discuss the legality of several riot-response tactics.