cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.djfpuq
title: Occurrence Download

description: A dataset containing 140201 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Picus sharpei (H.Saunders, 1872))",
 "HasCoordinate is true",
 "DecimalLatitude is greater than or equal to 29.93667",
 "DecimalLatitude is less than or equal to 51.91193",
 "DecimalLongitude is greater than or equal to -14.67522",
 "DecimalLongitude is less than or equal to 39.79752",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation)",
 "Year is greater than or equal to 1970",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 140201 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043147-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xwqqgp
title: Occurrence Download

description: A dataset containing 6 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hypoxis monanthos Baker"
 ]
}

 The dataset includes 6 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0251574-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4bf7c3
title: Occurrence Download

description: A dataset containing 40 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hypoxis membranacea Baker"
 ]
}

 The dataset includes 40 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0251572-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2g3n69
title: Occurrence Download

description: A dataset listing the 537549 species recorded in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Material sample, Specimen, Living Specimen)",
 "Country is United States of America",
 "OccurrenceStatus is Present"
 ]
}

 The dataset's 537549 records were derived from 2319 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0232396-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.71726/q7cztvad
title: Regional Profile Pilbara PIL04

description: Statistics and maps produced by GIS Branch, Department of Parks and Wildlife (2014)
DOI: 10.15468/dl.enxzdg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((15.6372 -28.0032,16.2782 -28.5786,20.509 -28.5786,20.509 -24.0715,15.4933 -24.0715,15.4945 -24.1257,16.0509 -25.6631,15.6372 -28.0032))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064236-250525065834625/datasets/export for details.
DOI: 10.71726/rb73az4l
title: Regional Profile Warren WAR01

description: Statistics and maps produced by GIS Branch, Department of Parks and Wildlife (2014)
DOI: 10.15468/dl.g9uvtw
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((15.4784 -23.4046,15.4933 -24.0715,20.509 -24.0715,20.509 -24.0455,20.0952 -23.5072,19.9968 -23.017,19.7843 -22.5405,19.1988 -21.8785,18.5972 -21.5447,17.8859 -21.3993,17.1626 -21.4805,16.5332 -21.7596,16.1257 -22.0882,15.8234 -22.4662,15.606 -22.8993,15.4784 -23.4046))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064237-250525065834625/datasets/export for details.
DOI: 10.71726/iicrtybb
title: Regional Profile Pilbara PIL03

description: Statistics and maps produced by GIS Branch, Department of Parks and Wildlife (2014)
DOI: 10.15468/dl.6428kp
title: Occurrence Download

description: A dataset containing 232 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Meconopsis betonicifolia Franch."
 ]
}

 The dataset includes 232 records from 36 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064239-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29310668.v9
title: Logic 14 pdf NEW

description: Logic innovation
DOI: 10.15468/dl.dme6t9
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((25.5395 -28.5786,20.509 -28.5786,20.509 -32.9007,25.5395 -32.9007,25.5395 -28.5786))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064240-250525065834625/datasets/export for details.
DOI: 10.71726/8xdpa121
title: Regional Profile Pilbara PIL02

description: Statistics and maps produced by GIS Branch, Department of Parks and Wildlife (2014)
DOI: 10.15468/dl.y4bz4v
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((20.7576 -24.3688,20.529 -24.0715,20.509 -24.0715,20.509 -28.5786,25.5395 -28.5786,25.5395 -24.0715,25.1306 -24.0715,24.9333 -24.4571,23.8962 -24.2467,22.8065 -24.295,22.3719 -24.7207,22.2323 -25.547,22.0387 -25.7188,21.7833 -25.7784,21.5388 -25.7113,21.3553 -25.5415,20.7576 -24.3688))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064241-250525065834625/datasets/export for details.
DOI: 10.57992/nmrxiv.p119
title: Tenuistones A–H, Flavonoid Derivatives from Miliusa tenuistipitata with Anti-Proliferative and Anti-Migration Activities Against Triple-Negative Breast Cancer Cells (DRAFT: CAE92EC7)

description: Tenuistones A–H (1–8), eight undescribed flavonoid derivatives were isolated from the twigs and leaves of Miliusa tenuistipitata. Compound 1 is a flavonol-naphthoquinone hybrid contained a unique 2-isopentenyl-2-methoxyacetyl-6-methyl-1,4-naphthoquinone unit with new carbon skeleton. Compound 2 represent the first example of flavonol-homogentisic acid-monoterpene hybrid. Compounds 3–8 are six novel flavonol-sesquiterpene hybrids. Seven pairs of enantiomers [(+)/(-)-1–4, (+)/(-)-6–8] were further resolved by chiral HPLC resolution. Their structures were established by a combination analysis of the NMR and MS data, along with chemical calculations. A plausible biogenetic pathway of compound 1 was proposed. Enantiomer (–)-3 displays profound anti-proliferative and anti-migration activities against triple-negative breast cancer cells.
DOI: 10.57992/nmrxiv.p119.s1231
title: Tenuistones F
DOI: 10.57992/nmrxiv.p119.s1231.d5274
title: Tenuistones F[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1231.d5275
title: Tenuistones F[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1231.d5276
title: Tenuistones F[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1231.d5277
title: Tenuistones F[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1231.d5278
title: Tenuistones F[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1231.d5279
title: Tenuistones F[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1231.d5280
title: Tenuistones F[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1232
title: Tenuistones C
DOI: 10.57992/nmrxiv.p119.s1232.d5281
title: Tenuistones C[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1232.d5282
title: Tenuistones C[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1232.d5283
title: Tenuistones C[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1232.d5284
title: Tenuistones C[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1232.d5285
title: Tenuistones C[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1232.d5286
title: Tenuistones C[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1232.d5287
title: Tenuistones C[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1233
title: Tenuistones A
DOI: 10.57992/nmrxiv.p119.s1233.d5288
title: Tenuistones A[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1233.d5289
title: Tenuistones A[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1233.d5290
title: Tenuistones A[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1233.d5291
title: Tenuistones A[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1233.d5292
title: Tenuistones A[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1233.d5293
title: Tenuistones A[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1233.d5294
title: Tenuistones A[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1235
title: Tenuistones E
DOI: 10.57992/nmrxiv.p119.s1235.d5302
title: Tenuistones E[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1235.d5303
title: Tenuistones E[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1235.d5304
title: Tenuistones E[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1235.d5305
title: Tenuistones E[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1235.d5306
title: Tenuistones E[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1235.d5307
title: Tenuistones E[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1234
title: Tenuistones B
DOI: 10.57992/nmrxiv.p119.s1234.d5295
title: Tenuistones B[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1235.d5308
title: Tenuistones E[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1234.d5296
title: Tenuistones B[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1234.d5297
title: Tenuistones B[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1234.d5298
title: Tenuistones B[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1234.d5299
title: Tenuistones B[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1234.d5300
title: Tenuistones B[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1234.d5301
title: Tenuistones B[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1236
title: Tenuistones D
DOI: 10.57992/nmrxiv.p119.s1236.d5309
title: Tenuistones D[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1236.d5310
title: Tenuistones D[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1236.d5311
title: Tenuistones D[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1236.d5312
title: Tenuistones D[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1236.d5313
title: Tenuistones D[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1236.d5314
title: Tenuistones D[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1236.d5315
title: Tenuistones D[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1237
title: Tenuistones G
DOI: 10.57992/nmrxiv.p119.s1237.d5316
title: Tenuistones G[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1237.d5317
title: Tenuistones G[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1237.d5318
title: Tenuistones G[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1237.d5319
title: Tenuistones G[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1237.d5320
title: Tenuistones G[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1237.d5321
title: Tenuistones G[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1237.d5322
title: Tenuistones G[NOESY]

description: NOESY
DOI: 10.57992/nmrxiv.p119.s1238
title: Tenuistones H
DOI: 10.57992/nmrxiv.p119.s1238.d5323
title: Tenuistones H[13C]

description: 13C
DOI: 10.57992/nmrxiv.p119.s1238.d5324
title: Tenuistones H[1H]

description: 1H
DOI: 10.57992/nmrxiv.p119.s1238.d5325
title: Tenuistones H[COSY]

description: COSY
DOI: 10.57992/nmrxiv.p119.s1238.d5326
title: Tenuistones H[DEPT]

description: DEPT
DOI: 10.57992/nmrxiv.p119.s1238.d5327
title: Tenuistones H[HMBC]

description: HMBC
DOI: 10.57992/nmrxiv.p119.s1238.d5328
title: Tenuistones H[HSQC]

description: HSQC
DOI: 10.57992/nmrxiv.p119.s1238.d5329
title: Tenuistones H[NOESY]

description: NOESY
DOI: 10.71726/xchn9uks
title: Regional Profile Pilbara PIL01

description: Statistics and maps produced by GIS Branch, Department of Parks and Wildlife (2014)
DOI: 10.15468/dl.etjenz
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((20.529 -24.0715,20.509 -24.0455,20.509 -24.0715,20.529 -24.0715))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064242-250525065834625/datasets/export for details.
DOI: 10.71726/bwhhee7x
title: Regional Profile Ord Victoria Plain OVP02

description: Statistics and maps produced by GIS Branch, Department of Parks and Wildlife (2014)
DOI: 10.34740/kaggle/dsv/12252087
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.15468/dl.2qf27n
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((25.5395 -23.2724,25.1306 -24.0715,25.5395 -24.0715,25.5395 -23.2724))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064243-250525065834625/datasets/export for details.
DOI: 10.15468/dl.psrxsq
title: Occurrence Download

description: A dataset containing 730 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllostachys aureosulcata McClure"
 ]
}

 The dataset includes 730 records from 67 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064245-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vc7hk5
title: Occurrence Download

description: A dataset containing 2851 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllostachys bambusoides Siebold & Zucc."
 ]
}

 The dataset includes 2851 records from 204 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064247-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tr9a3w
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((20.2855 -34.7533,20.509 -34.5676,20.509 -32.9007,17.7723 -32.9007,17.8156 -33.0786,18.3471 -33.7176,18.3748 -33.8287,18.2181 -34.0492,18.3197 -34.3408,18.4452 -34.429,18.5435 -34.4213,18.5872 -34.3667,18.5363 -34.167,18.7345 -34.1508,18.7216 -34.3637,18.7808 -34.4521,19.0289 -34.4206,19.0831 -34.4835,19.2655 -34.5017,19.2032 -34.6157,19.2394 -34.6926,19.375 -34.6963,19.6091 -34.8524,19.8251 -34.8396,19.9798 -34.9064,20.1081 -34.8731,20.1517 -34.7847,20.2855 -34.7533))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064246-250525065834625/datasets/export for details.
DOI: 10.25442/hku.29301449
title: Supporting Data for "Trophic Dynamics of the Coral Symbiosis: Evaluating Nutritional Strategies and Mechanisms of Acclimatization Under Environmental Change"

description: This repository contains supporting datasets and scripts relating to the thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at The University of Hong Kong, titled "Trophic Dynamics of the Coral Symbiosis: Evaluating Nutritional Strategies and Mechanisms of Acclimatization Under Environmental Change."Each folder associated with a thesis data chapter (Chapter 2 ["Ch2_Seasonality], Chapter 3 ["Ch3_Transplant"], and Chapter 4 ["Ch4_CSIA"]) houses two additional folders: one containing the supporting datasets generated for each respective chapter, and one containing the R scripts used for statistical analyses and/or producing figures. Detailed information on the individual files is described within the README text.
DOI: 10.25442/hku.29301449.v1
title: Supporting Data for "Trophic Dynamics of the Coral Symbiosis: Evaluating Nutritional Strategies and Mechanisms of Acclimatization Under Environmental Change"

description: This repository contains supporting datasets and scripts relating to the thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at The University of Hong Kong, titled "Trophic Dynamics of the Coral Symbiosis: Evaluating Nutritional Strategies and Mechanisms of Acclimatization Under Environmental Change."Each folder associated with a thesis data chapter (Chapter 2 ["Ch2_Seasonality], Chapter 3 ["Ch3_Transplant"], and Chapter 4 ["Ch4_CSIA"]) houses two additional folders: one containing the supporting datasets generated for each respective chapter, and one containing the R scripts used for statistical analyses and/or producing figures. Detailed information on the individual files is described within the README text.
DOI: 10.15468/dl.4kswzb
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Aphanizomenon A.Morren ex Bornet & Flahault, 1888",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((35.628 -23.023,35.6007 -22.9702,35.6007 -23.165,35.628 -23.023))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0064248-250525065834625/datasets/export for details.
DOI: 10.6084/m9.figshare.29379344
title: Supplementary Material for: A Newly Launched Nationwide Database Revealed Real-world Evidence on Systemic Therapy for Unresectable Hepatocellular Carcinoma in Japan: Hepatoma Registry of Integrating and Aggregating Electronic Health Record (HERITAGE)

description: Background & Aims
As systemic therapy for hepatocellular carcinoma (HCC) rapidly advances, eight treatment regimens are currently approved in Japan. However, the limited settings of phase III clinical trials necessitate large-scale real-world data to evaluate effective treatment sequences. To address this, we established a nationwide registry called the Hepatoma Registry of Integrating and Aggregating Electronic Health Records (HERITAGE).
Approach & Results
HERITAGE, associated with a nationwide follow-up survey by the Japan Liver Cancer Association, included cases where first-line systemic therapy commenced between April 2015 and December 2022. We collected data on treatment regimens, patient demographics, effectiveness, and duration, and assessed changes in regimens, trends in patient characteristics, efficacy per regimen, and cross-resistance in combinations of first- and second-line treatments. The study enrolled over 8000 treatment lines from 5,525 cases. Chronological analysis revealed a progression in first-line treatments from sorafenib to lenvatinib, and then to atezolizumab plus bevacizumab. These regimens were frequently reused in second and subsequent lines. There was an increase in older patients and those with non-viral etiologies and robust liver function. Treatments were generally initiated at earlier disease stages. Cross-resistance studies indicated that responses to second-line treatments were significantly influenced by the efficacy of first-line therapies, particularly in tyrosine kinase inhibitor (TKI) sequences. 
Conclusions
Through establishing a comprehensive registry, this study unveiled evolving patterns in treatment regimens and shifts in patient demographics for systemic HCC therapy in Japan.
DOI: 10.6084/m9.figshare.29379344.v1
title: Supplementary Material for: A Newly Launched Nationwide Database Revealed Real-world Evidence on Systemic Therapy for Unresectable Hepatocellular Carcinoma in Japan: Hepatoma Registry of Integrating and Aggregating Electronic Health Record (HERITAGE)

description: Background & Aims
As systemic therapy for hepatocellular carcinoma (HCC) rapidly advances, eight treatment regimens are currently approved in Japan. However, the limited settings of phase III clinical trials necessitate large-scale real-world data to evaluate effective treatment sequences. To address this, we established a nationwide registry called the Hepatoma Registry of Integrating and Aggregating Electronic Health Records (HERITAGE).
Approach & Results
HERITAGE, associated with a nationwide follow-up survey by the Japan Liver Cancer Association, included cases where first-line systemic therapy commenced between April 2015 and December 2022. We collected data on treatment regimens, patient demographics, effectiveness, and duration, and assessed changes in regimens, trends in patient characteristics, efficacy per regimen, and cross-resistance in combinations of first- and second-line treatments. The study enrolled over 8000 treatment lines from 5,525 cases. Chronological analysis revealed a progression in first-line treatments from sorafenib to lenvatinib, and then to atezolizumab plus bevacizumab. These regimens were frequently reused in second and subsequent lines. There was an increase in older patients and those with non-viral etiologies and robust liver function. Treatments were generally initiated at earlier disease stages. Cross-resistance studies indicated that responses to second-line treatments were significantly influenced by the efficacy of first-line therapies, particularly in tyrosine kinase inhibitor (TKI) sequences. 
Conclusions
Through establishing a comprehensive registry, this study unveiled evolving patterns in treatment regimens and shifts in patient demographics for systemic HCC therapy in Japan.