cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5923531
title: Ion-sensitive <i>in situ</i> hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: <i>in vitro</i> permeability, cytotoxicity and <i>in vivo</i> evaluation

description: Delivery of therapeutic molecules into the deeper ocular compartments is mainly hampered by short precorneal residence and limited transmembrane permeability of topically administered drugs. Hence, the current study was undertaken to fabricate the ion-sensitive <i>in situ</i> gels of natamycin (NT) bilosomes (NB) for efficient ocular delivery. The effect of cholesterol and sodium taurocholate proportion on the properties of the bilosomes were studied and the formulation with better physicochemical properties was optimized and utilized to derive the <i>in situ</i> gelling system (IG). The impact of type/composition of gelling agent on the formation and characteristics of the hydrogel was investigated. The hydrogel formed from IG with 0.3% w/v gellan gum showed optimal viscoelastic and adhesive characteristics. The ocular safety and cytocompatibility of NB and its IG was confirmed by corneal histology and <i>in vitro</i> cytotoxicity evaluation. A 6- to 9-fold enhancement in the transcorneal flux of NB demonstrated efficient ocular penetration of bilosomes. Moreover, the superior mean dose normalized NT levels in the ocular tissues of rabbits treated with optimized NB and IG illustrated the effectiveness of bilosomes loaded ion-sensitive <i>in situ</i> hydrogels as a potential platform for the improved and prolonged ocular pharmacotherapy.
DOI: 10.6084/m9.figshare.5923531.v1
title: Ion-sensitive <i>in situ</i> hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: <i>in vitro</i> permeability, cytotoxicity and <i>in vivo</i> evaluation

description: Delivery of therapeutic molecules into the deeper ocular compartments is mainly hampered by short precorneal residence and limited transmembrane permeability of topically administered drugs. Hence, the current study was undertaken to fabricate the ion-sensitive <i>in situ</i> gels of natamycin (NT) bilosomes (NB) for efficient ocular delivery. The effect of cholesterol and sodium taurocholate proportion on the properties of the bilosomes were studied and the formulation with better physicochemical properties was optimized and utilized to derive the <i>in situ</i> gelling system (IG). The impact of type/composition of gelling agent on the formation and characteristics of the hydrogel was investigated. The hydrogel formed from IG with 0.3% w/v gellan gum showed optimal viscoelastic and adhesive characteristics. The ocular safety and cytocompatibility of NB and its IG was confirmed by corneal histology and <i>in vitro</i> cytotoxicity evaluation. A 6- to 9-fold enhancement in the transcorneal flux of NB demonstrated efficient ocular penetration of bilosomes. Moreover, the superior mean dose normalized NT levels in the ocular tissues of rabbits treated with optimized NB and IG illustrated the effectiveness of bilosomes loaded ion-sensitive <i>in situ</i> hydrogels as a potential platform for the improved and prolonged ocular pharmacotherapy.
DOI: 10.48370/ofd/evfjpq
title: Cristinia helvetica (Pers.) Parmasto, 2513

description: Fungarium Macromycetes
DOI: 10.48370/ofd/bal0td/f5hgna
title: MRIPAS_coll_31485_PitymysSubterraneus_1963_scan.jpg

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DOI: 10.48370/ofd/bal0td/bp1gze
title: MRIPAS_coll_31485_PtymysSubterraneus_1963_M_body_scan_ct.swf

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DOI: 10.48370/ofd/bal0td
title: Microtus subterraneus - 31485, Zoological collection of the Mammal Research Institute, PAS

description: Microtus subterraneus (European pine vole) from Zoological collection of the Mammal Research Institute, PAS. Collected 1963-04-01, in: Białowieża, Poland. Material type: body
DOI: 10.25625/7v5h1a/cegnea
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DOI: 10.5281/zenodo.6483368
title: Hintereisferner energy balance data set

description: This resource provides meteorological and glaciological data from two automatic weather stations operated at Hintereisferner glacier (Austria). The data cover a full annual glaciological cycle (Oct. 2003- Nov. 2004) and allow for investigation of the year-round local meteorological conditions and surface exchange processes in the ablation and accumulation area of the glacier. The data may also be used to drive and validate respective numerical models.
description: {"references": ["https://www.uibk.ac.at/acinn/theses/diploma-theses/schrott_daniel_2006_dipl.pdf", "https://www.uibk.ac.at/acinn/theses/diploma-theses/kolar_gunther_2008_dipl_0.pdf", "https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2006WR005065", "https://nag.iasc.info/images/publications/abstracts/IASC_NAG_Abstracts_2006.pdf"]}
DOI: 10.25625/7v5h1a/xu5sg4
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DOI: 10.5281/zenodo.6483367
title: Hintereisferner energy balance data set

description: This resource provides meteorological and glaciological data from two automatic weather stations operated at Hintereisferner glacier (Austria). The data cover a full annual glaciological cycle (Oct. 2003- Nov. 2004) and allow for investigation of the year-round local meteorological conditions and surface exchange processes in the ablation and accumulation area of the glacier. The data may also be used to drive and validate respective numerical models.
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DOI: 10.48370/ofd/c6dwlc
title: Cristinia helvetica (Pers.) Parmasto, 2858

description: Fungarium Macromycetes
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