cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15454/5x8l3x/sbzifj
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title: STPE1306-0606-50b.jpg
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title: STPE1306-0163-40d.jpg
DOI: 10.15454/5x8l3x/x0e085
title: STPE1306-0045-40c.jpg
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title: STPE1306-0590-40a.jpg
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title: STPE1306-0531-40a.jpg
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title: STPE1306-0252-35a.jpg
DOI: 10.15454/5x8l3x/x2yne9
title: STPE1306-0476-50c.jpg
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title: STPE1306-0448-40c.jpg
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title: STPE1306-0601-40b.jpg
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title: STPE1306-0266-40c.jpg
DOI: 10.6084/m9.figshare.16619773.v23
title: Data from "Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation"

description: Data from "Levels of Notch-regulated transcription are modulated by tissue movements at gastrulation":<br>- raw MS2 Live imaging movies: 124 '.lif' files captured in a Leica SP8 confocal. Each is a 1-2h movie of a developing fly embryo in the genetic condition described in the file name. The metadata file contains the information linking each movie with parameters used for image analysis and identifier of the genetic condition ("nickname" column).<br>- data obtained from image analysis: '.mat' files obtained from MATLAB after image analysis for each movie. README contains information of the data structure and all variables stored in each.<br>- numerical data used for figures: text files containing data points used in all figures in the paper. "NumericalData.txt" contains the information about each plot, axes, figure where it's used and name of the file containing the numerical data.
DOI: 10.15454/5x8l3x/x6exrj
title: STPE1306-0177-40b.jpg
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title: STPE1306-0270-40d.jpg
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title: STPE1306-0499-40c.jpg
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title: STPE1306-0307-40d.jpg
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title: STPE1306-0360-45c.jpg
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title: STPE1306-0314-40c.jpg
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title: STPE1306-0505-40a.jpg
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title: STPE1306-0241-40c.jpg
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title: STPE1306-0549-35b.jpg
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title: STPE1306-0144-55b.jpg
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title: STPE1306-0308-40a.jpg
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title: STPE1306-0223-40b.jpg
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title: STPE1306-0471-40b.jpg
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DOI: 10.15454/5x8l3x/xuilnd
title: STPE1306-0551-40d.jpg
DOI: 10.15454/5x8l3x/xuxzhh
title: STPE1306-0155-40d.jpg
DOI: 10.15454/5x8l3x/xvrtz4
title: STPE1306-0417-40b.jpg
DOI: 10.15454/5x8l3x/xw301y
title: STPE1306-0243-40a.jpg
DOI: 10.15454/5x8l3x/xx63er
title: STPE1306-0288-40c.jpg
DOI: 10.15454/5x8l3x/xxvcoo
title: STPE1306-0609-40c.jpg
DOI: 10.15454/5x8l3x/xy34a6
title: STPE1306-0185-40b.jpg
DOI: 10.15454/5x8l3x/xywlrk
title: STPE1306-0471-40c.jpg
DOI: 10.15454/5x8l3x/xyzzvn
title: STPE1306-0242-40d.jpg
DOI: 10.15454/5x8l3x/xz8gab
title: STPE1306-0358-40a.jpg
DOI: 10.15454/5x8l3x/xzxoj0
title: STPE1306-0402-50b.jpg
DOI: 10.15454/5x8l3x/y0cifo
title: STPE1306-0090-40d.jpg
DOI: 10.15454/5x8l3x/y2bqjw
title: STPE1306-0176-40d.jpg
DOI: 10.6084/m9.figshare.13634371.v1
title: Additional file 4 of A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

description: Additional file 4: Table S4. Detail information of the detected CNVRs.
DOI: 10.6084/m9.figshare.16780107.v1
title: Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury

description: The purpose of this work is to probe into the potential role of long non-coding RNA growth arrest specific transcript 5 (lncGAS5)/ microRNA (miR)-188-5p/SMAD2 axis in MIRI. Through ligating the left anterior descending (LAD) coronary artery, MIRI animal model and hypoxia/reoxygenation (H/R) myocardial injury model <i>in vitro</i> were established. Via adenovirus or plasmid transfection, lncGAS5/MiR-188-5p/SMAD2 expression was up-regulated or down-regulated in the study. RT-qPCR was applied to check LncGAS5/MiR-188-5p/SMAD2 mRNA expression, HE staining for histopathological staining, TUNEL staining and flow cytometry to examine cardiomyocyte apoptotic rate, CCK-8 to check cell viability, ELISA to detect inflammatory factor levels, Western blot to examine Bax, Bcl-2, cleaved caspase-3, NF-κB and SMAD2 expression, and dual luciferase reporter experiment to examine the targeting relationship of miR-188-5p with LncGAS5 and SMAD2. The results indicated that LncGAS5 and SMAD2 were highly expressed in MIRI and miR-188-5p was under-expressed. Silencing LncGAS5 and SMAD2 or overexpressing miR-188-5p could reduce MIRI in myocardial tissue, cardiomyocyte apoptosis, inhibit Bax, cleaved caspase-3 and NF-κB expressions and promote Bcl-2 expression, while reducing inflammatory factors TNF -α, IL-1β and IL-6 levels. Overexpressing LncGAS5 promoted MIRI. Additionally, the impact of silencing LncGAS5 on MIRI could be reversed through inhibiting miR-188-5p. LncGAS5 acted as a sponge of miR-188-5p to target SMAD2 expression. In conclusion, Silencing LncGAS5 is available to improve MIRI through regulating miR-188-5p/SMAD2 axis, and may be used as a potential target for treating MIRI in the future.