cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2p4xlc
title: CCDC 2477383: Experimental Crystal Structure Determination

description: Related Article: RACHANA CHOUDHARY|2025|CSD Communication|||
description: Related Article: Rachana Choudhary, Kritika Dogra,  Monika, Basab Bijayi Dhar|2026|Cat.Sci.Tech.|||doi:10.1039/d5cy01283j
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2pmykv
title: CCDC 2491828: Experimental Crystal Structure Determination

description: Related Article: Rachana Choudhary, Kritika Dogra,  Monika, Basab Bijayi Dhar|2026|Cat.Sci.Tech.|||doi:10.1039/d5cy01283j
description: Related Article: RACHANA CHOUDHARY|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5061/dryad.h5g7nt7
title: Data from: Head-to-head drug comparisons in multiple sclerosis: urgent action needed

description: Disease-modifying drugs are changing the natural history of multiple
 sclerosis (MS). However, currently available clinical trial data are
 insufficient to develop accurate personalised treatment algorithms to
 assign the best possible treatment to each person with MS according to
 disease features, treatment history and comorbidities. Such accurate
 algorithms would require the presence of numerous head-to-head trials of
 long duration, which is virtually impossible, given the economic costs,
 required time and difficulties with attrition. Thus, efforts are being
 made to compare relative treatment efficacy through observational designs,
 using large multi-centre prospective cohorts or ‘big MS data’, and network
 meta-analyses. Although such studies can yield useful information, they
 are liable to biases and their results should be confirmed in other study
 populations, including smaller, single-centre cohorts, where some of these
 biases can be minimised. In this View paper we analyse the potential
 benefits and biases of all these strategies alternative to head-to-head
 trials in MS. Finally, we propose the combination of all these types of
 studies to obtain reliable head-to-head drug comparisons in the absence of
 randomised designs.
description: Extra Table and &
 Extra ReferencesExtra Table and
 Corresponding References & Extra References for Tables 1 and 3 of Main
 DocumentExtraTableAndCorrespondingRefs_&_ExtraRefsForTables1And3OfMainDoc_190401_2.docx
DOI: 10.5061/dryad.21b18v3
title: Data from: Lp-PLA2 and dual antiplatelet agents in intracranial arterial stenosis

description: Objective: To evaluate the interaction effect of lipoprotein-associated
 phospholipase A2 (Lp-PLA2) activity on the efficacy and safety of
 dual/single antiplatelet therapy in patients with and without intracranial
 arterial stenosis (ICAS) by the Clopidogrel in High-Risk Patients with
 Acute Non-disabling Cerebrovascular Events (CHANCE) trial. Methods:
 Subjects with both MR imaging analysis and Lp-PLA2 testing results were
 included in the current subanalysis. The interaction of Lp-PLA2 activity
 with the effects of dual and single antiplatelet therapy were analyzed
 through cox proportional hazards regressions model. Results: Among the 797
 patients, the mean age was 63.1±10.8 years, 518 (65%) were men, 356
 (44.7%) patients had ICAS and 441 (55.3%) did not. There are significantly
 more patients with elevated Lp-PLA2 activity in the ICAS group than that
 in the non-ICAS group (43.8% versus 35.4%, p=0.02). There was significant
 interaction between Lp-PLA2 activity levels and the two antiplatelet
 therapy for prevention of stroke recurrences and combined vascular events
 even after adjustment for confounding factors exclusively for patients
 with ICAS (p=0.016, 0.016, respectively), but not for those without
 (p=0.289, 0.597, respectively). Compared with aspirin alone, dual
 antiplatelet therapy significantly reduced the risk of stroke recurrences
 and combined vascular events (adjusted hazard ratio=0.33 [0.12-0.88],
 p=0.026; 0.33 [0.12-0.88], p=0.026, respectively) for patients with both
 ICAS and non-elevated Lp-PLA2 activity. Conclusions: Presence of both ICAS
 and non-elevated Lp-PLA2 activity may predict better response to dual
 antiplatelet therapy in prevention of recurrent strokes and combined
 vascular events for patients with minor stroke or high-risk TIA.
description: eTable 1+2-for Neurology
 RevisionSupplemental eTable
 1+2eTable
 1+2-Revision.docx
DOI: 10.5061/dryad.r7mh8sr
title: Data from: Type Maastrichtian gastropod faunas evidencing rapid ecosystem recovery following the Cretaceous-Palaeogene boundary

description: The study of the global mass extinction event at the Cretaceous–Palaeogene
 (K/Pg) boundary can aid in understanding patterns of selective extinction
 and survival, and dynamics of ecosystem recovery. Outcrops in the
 Maastrichtian type area (southeast Netherlands, northeast Belgium)
 comprise an exceptionally expanded K/Pg boundary succession that offers a
 unique opportunity to study marine ecosystem recovery within the first
 thousands of years following the mass extinction event. A quantitative
 analyses was performed on systematically sampled macrofossils of the
 topmost Maastrichtian and lowermost Danian strata at the former
 Curfs-Ankerpoort quarry (Geulhem), which represent ‘snapshots’ of the
 latest Cretaceous and earliest Palaeogene marine ecosystems, respectively.
 Molluscs in particular are diverse and abundant in the studied succession.
 Regional ecosystem changes across the K/Pg boundary are relatively minor,
 showing a decline in suspension feeders, accompanied by an ecological
 shift to endobenthic molluscs. The earliest Paleocene gastropod assemblage
 retains many ‘Maastrichtian’ features and documents a fauna that
 temporarily survived into the Danian. The shallow, oligotrophic carbonate
 platform in this area was inhabited by taxa that were adapted to low
 nutrient levels and resistant to starvation. As a result, the local taxa
 were less affected by the short-lived detrimental conditions related to
 K/Pg boundary perturbations, such as darkness, cooling, starvation and
 ocean acidification. This resulted in relatively high survival rates,
 which enabled rapid recolonization and recovery of marine faunas in the
 Maastrichtian type area.
description: DataData for manuscript. S1
 Data; S2 Groups; S3 formgroups and ecology; S4 species ranges; S5 Tiering,
 feeding, motilityVellekoop et al
 SUPPORTING INFORMATIONsupporting information
 to manuscript
DOI: 10.5061/dryad.fh8k355
title: Data from: Temporal, spatial and household dynamics of typhoid fever in Kasese district, Uganda

description: Typhoid fever affects 21 million people globally, 1% of whom succumb to
 the disease. The social, economic and public health consequences of this
 disease disproportionately affect people in Africa and Asia. In order to
 design context specific prevention strategies, we need to holistically
 characterise outbreaks in these settings. Here we used retrospective data
 (2013-2016) at national and district level to characterize temporal and
 spatial dynamics of typhoid fever outbreaks using time series and spatial
 analysis. We then selected cases matched with controls to investigate
 household socio-economic drivers using a conditional logistic regression
 model, in addition to develop a typhoid outbreak-forecasting framework.
 The incidence rate of typhoid fever at national and district level was ~
 160 and 60 cases per 100,000 persons per year, respectively, predominantly
 in urban areas. Bwera sub-county registered the highest incidence rate,
 followed by Kisinga, Kitholhu and Nyakiyumbu sub-counties. The male-female
 case ratio at district level was at 1.68 and outbreaks occurred between
 the 20th and 40th week (May and October) each year preceded by seven weeks
 of precipitation. Our forecasting framework predicts outbreaks better at
 the district rather than at the national level. We have identified a
 temporal window associated with typhoid fever outbreaks in Kasese
 district, which is preceded by precipitation, flooding and displacement of
 people. We also observed that high typhoid incidence areas also had high
 environmental contamination with limited water treatment. Taken together
 with the forecasting framework, this knowledge can inform the development
 of specific control and preparedness strategies at district and national
 levels.
description: <strong>NATIONAL_DATASET.csv</strong> - Ministry of
 Health surveillance database (2013-2015) with corresponding weather used
 in the retrospective study <strong>HOSPITAL
 DATASET.csv</strong> - Health records of Typhoid fever patients from
 the three hospitals in Kasese district
 <strong>HOUSEHOLD DATASET.csv</strong> - Database
 from the Case-Control study <strong>FORECAST
 DATASET.csv</strong> - Ministry of Health Surveillance Database
 (2016-2017) used for validation of the forecast framework
 <strong>HOUSEHOLD DATASET.RData</strong>
 <strong>TYPHOID_ANALYSIS_RCODE.html</strong> <strong>TYPHOID_ANALYSIS_RCODE.Rmd</strong> <strong>KASESE_WEATHER_FORCASTING.csv</strong>
DOI: 10.5061/dryad.04n8502
title: Data from: Alzheimer Disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal

description: Objective: To identify potential predictors for outcome in individuals
 with mild cognitive impairment (MCI) who have reverted to normal cognition
 (NC). Methods: We selected individuals with MCI, who reverted at follow-up
 to NC, with follow-up after reversion from ADNI. Common clinical markers,
 AD biomarkers, and neurodegeneration imaging markers were used to compare
 MCI reverters based on subsequent clinical outcome (i.e. subsequent
 decline or stable reversion). For independent comparison, findings of the
 clinical Amsterdam Dementia Cohort are presented. Results: Seventy-seven
 (10%) out of 757 individuals with MCI reverted to NC and 61 individuals of
 these had follow-up data available. After 3.2±2.2 years 16 (24%)
 progressed to MCI, and 3 (5%) to dementia. Those who declined were older
 and had a higher amyloid PET burden and higher cerebrospinal fluid (CSF)
 tau levels. Conclusion: In MCI reverters, abnormal biomarkers for AD
 pathology are associated with subsequent decline. AD biomarkers may aid in
 the prognosis of reverting MCI.
description: Supplemental_materials_Vermunt_Neurology_Alzheimer Disease biomarkers may aid in the prognosis of MCI cases initially reverted to normalSupplemental tables and figures.
DOI: 10.5061/dryad.sh54526
title: Data from: Patient-Reported Symptoms in Facioscapulohumeral Muscular Dystrophy (PRISM-FSHD)

description: Objective: To determine the frequency and relative importance of the most
 meaningful symptoms in facioscapulohumeral muscular dystrophy (FSHD) and
 to identify the demographic and clinical features that are associated with
 the greatest disease burden in this population. Methods: We performed a
 cross-sectional study involving 328 FSHD participants. Collectively,
 participants reported the prevalence and relative importance of 274
 symptoms and 15 symptomatic themes. We assessed the association between
 symptomatic theme prevalence and participants’ age, sex, disease duration,
 pain level, employment status, and education. Results: Participants
 answered over 48,000 questions regarding their disease burden. The
 symptomatic themes with the highest prevalence in our sample were problems
 with shoulders or arms (96.9%), limitations with activities (94.7%), core
 weakness (93.8%), fatigue (93.8%), limitations with mobility and walking
 (93.6%), changed body image due to the disease (91.6%) and pain (87.7%).
 Problems with shoulders and arms and limitations with mobility and walking
 had the greatest effect on participants’ lives. Employment status and the
 report of pain had the most extensive association with the prevalence of
 symptoms with employment being associated with 8/15 of the symptomatic
 themes and pain being associated with 7/15 of the symptomatic themes. Men
 and women with FSHD experienced a similar prevalence of all symptomatic
 themes. Conclusions: Adults with FSHD experience a variety of symptoms
 that play an important role in their disease burden. These symptoms have a
 variable prevalence and importance in the FSHD population and are
 associated with disease duration, employment status, and pain level.
description: Table5_dryadPrevalence and relative importance of specific symptoms in FSHD
DOI: 10.5061/dryad.jq7460s
title: Data from: A quantitative and statistical discrimination of morphotaxa within the Ediacaran genus Palaeopascichnus

description: The Palaeopascichnida are a relatively understudied component of the
 Ediacaran biota. The eponymous Palaeopascichnus delicatus is comprised of
 serially arranged, mm-scale allantoid chambers that have variously been
 interpreted as evidence of movement, feeding traces, and body fossils of
 various affinities. Palaeopascichnus has most recently been compared to
 the deep-marine Xenophyophora, an extant group of large benthic protists
 that is characterized by large size and possession of stercomata within
 their cells. The construction and growth of the palaeopascichnids, and its
 implications for their phylogenetic affinity, are assessed using material
 from the Avalon Peninsula of Newfoundland, Canada. The application of
 quantitative morphological analysis to the study of over ninety
 well-preserved specimens of Palaeopascichnus demonstrates considerable
 variation in chamber shape and size, and in behaviour along the chamber
 series. The combination of morphometric and multivariate statistical
 analysis allows the recognition of natural groups within the dataset,
 thereby demonstrating variability within and between morphospecies.
 Morphological comparisons of fossil palaeopascichnids with extant
 protistan taxa support the proposed protistan affinity of
 Palaeopascichnus, allowing further resolution regarding the diversity and
 disparity within this prominent element of the later Ediacaran biotas of
 Gondwana and Baltica.
description: Spreadsheet of all
 data_Hawco et al.All specimens,
 measurements, characters used in study and the full results of the cluster
 assignments.total_data_spreadsheet_Hawco et
 al..xlsxInterpretations of all
 cluster analyses_Hawco et al.Breakdown of how we
 interpreted the schematics for each cluster, as well as showing the
 averages for each character in each cluster for all
 iterationsInterpretations of cluster
 analyses_Hawco et al..xlsxSupplementary_information_Hawco_et_alSupplementary information file including results for the iteration where the branching palaeopascichnus specimens are treated separately, full table identifying the specimens used in the study, full hierarchical clustering trees for every iteration and the interpretations of schematics associated with the clusters.SI_PP_Hawco.docx
DOI: 10.5061/dryad.b182780
title: Data from: Phylogenomic analyses of the Photinia complex support the recognition of a new genus Phippsiomeles and the resurrection of a redefined Stranvaesia in Maleae (Rosaceae)

description: Photinia and its morphologically similar allies in Maleae (Rosaceae)
 consist of five currently recognized genera: Aronia, Heteromeles,
 Photinia, Pourthiaea, and Stranvaesia, and 68 species, distributed in Asia
 and North & Central America. Despite previous efforts to clarify
 relationships in this group, the generic delimitations have remained
 uncertain. Our goals were to reconstruct a robust phylogeny of Photinia
 and its close allies to test the monophyly of the currently recognized
 genera, especially Photinia and Stranvaesia, and the hybrid origin
 hypothesis of Photinia bodinieri. This study employs complete plastomes
 and the entire nrDNA assembled from the genome skimming approach with a
 broad taxon sampling of 81 species in 30 genera of Rosaceae, especially
 Maleae. Based on three datasets, including the whole plastome (WP), coding
 sequence (CDS) and nrDNA repeats, the results of Maximum likelihood (ML)
 and Bayesian analyses (BI) showed that Stranvaesia and Photinia, as
 previously circumscribed, were each non-monophyletic. Six clades have been
 recovered herein within Photinia and its allied genera: Aronia,
 Heteromeles, Photinia s.s., Pourthiaea, Stranvaesia, and a new genus
 Phippsiomeles consisting of the Central American species formerly placed
 in Photinia. The strong conflicts between the plastome and nrDNA
 phylogenies of Phippsiomeles and Stranvaesia tomentosa suggest the
 possibility that they may have each originated involving hybridization
 events, while no incongruence among datasets was detected to support the
 hybrid origin of Photinia bodinieri. We provide 12 new combinations, to
 transfer eight taxa of the New World Photinia into Phippsiomeles and
 clarify the generic placements of several species of Photinia and
 Stranvaesia.
description: Appendix
 1Jobs
 used for the assembly of plastome and phylogenetic analyses on
 HydraApp.
 1.zipFig.
 S1Fig. S1. The
 phylogenetic relationships within Maleae resolved by coding sequences
 (CDSs). Numbers associated with the branches are ML bootstrap value (BS)
 and BI posterior probabilities (PP), only the values, which are not 100/1
 are presented.Fig.
 S1The
 phylogenetic relationships (only illustrating the ML tree) within Maleae
 resolved by coding sequences (CDSs) of plastome. Numbers associated with
 the branches are ML bootstrap value (BS) and BI posterior probabilities
 (PP), only the values, which are not 100/1 are
 presented.Tab. S1 Comparison of
 taxon names used in Liu & Hong (2016ab, 2017), Lu & Spongberg
 (2003), Phipps (1992, 2014), and this study.Comparison of taxon
 names used in Liu & Hong (2016ab, 2017), Lu & Spongberg (2003),
 Phipps (1992, 2014), and this study
DOI: 10.5061/dryad.nj3831m
title: Data from: Oldest, smallest and phylogenetically most basal pelagornithid, from the early Paleocene of New Zealand, sheds light on the evolutionary history of the largest flying birds

description: The Cenozoic Pelagornithidae, or pseudotoothed birds, are characterized by
 unique bony projections along the cutting edges of the beak. These birds
 were previously known from late Paleocene to Pliocene fossil sites and
 some species reached wingspans up to 6.4 metres. Here we describe a
 partial skeleton of a small-sized pelagornithid from the early Paleocene
 of New Zealand. Protodontopteryx ruthae, gen. et sp. nov. is the oldest
 record of the clade, the smallest known species, and the first pre-Eocene
 pelagornithid from the Southern Hemisphere. The skull of the new species
 exhibits the characteristic pelagornithid morphology, but the postcranial
 skeleton distinctly differs from other pelagornithids and various
 plesiomorphic features indicate that it is the earliest-diverging
 representative of the Pelagornithidae. The much stouter humerus suggests
 that the new species was less adapted to sustained soaring than previously
 known pelagornithids. Pseudoteeth therefore evolved before pelagornithids
 became highly specialized gliders. Unlike the giant Neogene pelagornithid
 species, which presumably were skimmers, early Paleocene pelagornithids
 are likely to have targeted selected prey items and may have been
 predominantly piscivorous. The new species furthermore suggests that
 pelagornithids evolved in the Southern Hemisphere and documents a very
 early radiation of neornithine seabirds, which may have been triggered by
 changes in marine ecosystems around the K-Pg boundary. We finally comment
 on the unusual preservation of the fossil, which may be due to the
 activity of marine scavengers.
description: Mayr et al nexus
 fileNexus file used in
 phylogenetic analysisMayr et al Character
 descriptions and character matrixCharacter descriptions,
 and character matrix used in the phylogenetic analysisProtodontopteryx DICOM
 dataDicom file of holotype
 of Protodontopteryx ruthae, gen. et sp. nov.Protodontopteryx.zip
DOI: 10.5061/dryad.1gj36nn
title: Data from: Juggling options: optimal selection of size-weight combinations of Aldina latifolia (Papilionoideae: Fabaceae) pods by Cacajao ouakary (Primates)

description: 1. Optimal foraging theory predicts that animals will seek simultaneously
 to minimize food processing time and maximize energetic gain. Overall,
 when abundances are equal, this leads to preference for bigger prey items.
 However, for species where upper size ranges are such that effective
 processing requires protracted processing time, choosing medium-sized
 items may be more energetically rewarding, even though larger ones have
 more embodied energy. 2. We evaluated whether a specialist seed-predator
 primate would forage optimally when choosing between variable sized
 thick-husked fruits, and consume the size-class requiring least time to
 obtain, handle and ingest, and was easiest to manipulate. 3. We tested
 this with the golden-backed uacari (Cacajao ouakary, Pitheciidae), and
 single-seeded pods of the macucu tree (Aldina latifolia, Fabaceae). We
 used scan-sampling and ad libitum feeding observations; fruit
 penetrability measured with a prosthetic uacari canine; measurements of C.
 ouakary hands obtained from museum specimens. To test if uacaris selected
 for optimal characteristics, we compared 27 metrics from eaten and uneaten
 seeds/fruits. 4. Uacaris selected fruits of medium size and weight
 disproportionately to their abundance. Large fruit processing times were
 over six times greater than for medium-sized fruits, but seeds were only
 four times as large, so that, for energetic yield per unit time, choosing
 medium-sized pods was optimal. 5. Disproportionate selection by C. ouakary
 of fruits of medium-size and mass in relation to their abundance shows a
 primate selecting a sub-sample from the available weight-size continuum,
 selectivity that presumably maximizes trade-offs between the energy
 derived from a seed, and time and energy expended in processing fruit to
 access this, so following optimal foraging theory predictions. The greater
 time spent processing large pods is attributed to difficulties
 manipulating objects five to seven times the size of the animal’s palm and
 one-sixth its own body weight.
description: data_cacajao_aldina_measurements_and_hand_c_ouakaryThe current data is part of a broader field study of golden-backed uacari foraging ecology conducted in Jaú National Park – Amazonas, Brazil, to which biometric data on hands of C. ouakary specimens in Brazilian and British museums has been added. All analyses were done in R (R Core Team 2016).dates_cacajao_aldina_measurements_and_hand_c_ouakary.xlsx