cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5406787.v8
title: Succinic acid treatment of SCA1 transgenic mice

description: Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitochondrial oxidative phosphorylation (OXPHOS) deficits in cerebellar tissue of a Purkinje cell-driven spinocerebellar ataxia type 1 (SCA1) mouse. Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase). Complex I genes are upregulated at the time of symptom onset and upregulation persists into late stage disease; yet, functional assembly of complex I macromolecules are diminished and oxygen respiration through complex I is reduced. Acute treatment of postsymptomatic SCA1 mice with succinic acid, a complex II (succinate dehydrogenase) electron donor to bypass complex I dysfunction, ameliorated cerebellar OXPHOS dysfunction, reduced cerebellar pathology and improved behavior. Thus, treatment with succinic acid shows promise as a therapeutic adjuvant in neurodegenerative ataxias, and warrants further investigation. <b><br></b><b>All data from this manuscript will be made available upon acceptance by PLoS One.</b>
DOI: 10.6084/m9.figshare.5406511
title: Bike

description: Data collected from bicyclists.
DOI: 10.6084/m9.figshare.5406511.v1
title: Bike

description: Data collected from bicyclists.
DOI: 10.6084/m9.figshare.5406787.v9
title: Succinic acid treatment of SCA1 transgenic mice

description: Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitochondrial oxidative phosphorylation (OXPHOS) deficits in cerebellar tissue of a Purkinje cell-driven spinocerebellar ataxia type 1 (SCA1) mouse. Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase). Complex I genes are upregulated at the time of symptom onset and upregulation persists into late stage disease; yet, functional assembly of complex I macromolecules are diminished and oxygen respiration through complex I is reduced. Acute treatment of postsymptomatic SCA1 mice with succinic acid, a complex II (succinate dehydrogenase) electron donor to bypass complex I dysfunction, ameliorated cerebellar OXPHOS dysfunction, reduced cerebellar pathology and improved behavior. Thus, treatment with succinic acid shows promise as a therapeutic adjuvant in neurodegenerative ataxias, and warrants further investigation. <b><br></b><b>All data from this manuscript will be made available upon acceptance by PLoS One.</b>
DOI: 10.6084/m9.figshare.5406496
title: Bus

description: Data collected from bus commuters.
DOI: 10.6084/m9.figshare.5406499
title: Tone production and perception and intelligibility of produced speech in Mandarin-speaking cochlear implanted children

description: <i>Objective</i>: This study explored tone production, tone perception and intelligibility of produced speech in Mandarin-speaking prelingually deaf children with at least 5 years of cochlear implant (CI) experience. Another focus was on the predictive value of tone perception and tone production as they relate to speech intelligibility. <i>Design</i>: Cross-sectional research. <i>Study sample</i>: Thirty-three prelingually deafened children aged over eight years with over five years of experience with CI underwent tests for tone perception, tone production, and the Speech Intelligibility Rating (SIR). A Pearson correlation and a stepwise regression analysis were used to estimate the correlations among tone perception, tone production, and SIR scores. <i>Results</i>: The mean scores for tone perception, tone production, and SIR were 76.88%, 90.08%, and 4.08, respectively. Moderately positive Pearson correlations were found between tone perception and production, tone production and SIR, and tone perception and SIR (<i>p</i> p p p Conclusions: Mandarin-speaking cochlear-implanted children with sufficient duration of CI use produce intelligent speech. Speech intelligibility can be predicted by tone production performance.
DOI: 10.6084/m9.figshare.5406538.v1
title: DDY

description: imbalanced datasets drug
DOI: 10.6084/m9.figshare.5406487
title: Driving Windows Down

description: Data collected from driving with windows down (open)
DOI: 10.6084/m9.figshare.5406496.v1
title: Bus

description: Data collected from bus commuters.
DOI: 10.6084/m9.figshare.5406499.v1
title: Tone production and perception and intelligibility of produced speech in Mandarin-speaking cochlear implanted children

description: <i>Objective</i>: This study explored tone production, tone perception and intelligibility of produced speech in Mandarin-speaking prelingually deaf children with at least 5 years of cochlear implant (CI) experience. Another focus was on the predictive value of tone perception and tone production as they relate to speech intelligibility. <i>Design</i>: Cross-sectional research. <i>Study sample</i>: Thirty-three prelingually deafened children aged over eight years with over five years of experience with CI underwent tests for tone perception, tone production, and the Speech Intelligibility Rating (SIR). A Pearson correlation and a stepwise regression analysis were used to estimate the correlations among tone perception, tone production, and SIR scores. <i>Results</i>: The mean scores for tone perception, tone production, and SIR were 76.88%, 90.08%, and 4.08, respectively. Moderately positive Pearson correlations were found between tone perception and production, tone production and SIR, and tone perception and SIR (<i>p</i> p p p Conclusions: Mandarin-speaking cochlear-implanted children with sufficient duration of CI use produce intelligent speech. Speech intelligibility can be predicted by tone production performance.
DOI: 10.6084/m9.figshare.5406472
title: Driving Windows Up

description: Data collected from driving with windows up
DOI: 10.6084/m9.figshare.5406487.v1
title: Driving Windows Down

description: Data collected from driving with windows down (open)
DOI: 10.6084/m9.figshare.5406787.v10
title: Succinic acid treatment of SCA1 transgenic mice

description: Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitochondrial oxidative phosphorylation (OXPHOS) deficits in cerebellar tissue of a Purkinje cell-driven spinocerebellar ataxia type 1 (SCA1) mouse. Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase). Complex I genes are upregulated at the time of symptom onset and upregulation persists into late stage disease; yet, functional assembly of complex I macromolecules are diminished and oxygen respiration through complex I is reduced. Acute treatment of postsymptomatic SCA1 mice with succinic acid, a complex II (succinate dehydrogenase) electron donor to bypass complex I dysfunction, ameliorated cerebellar OXPHOS dysfunction, reduced cerebellar pathology and improved behavior. Thus, treatment with succinic acid shows promise as a therapeutic adjuvant in neurodegenerative ataxias, and warrants further investigation. <b><br></b><b>All data from this manuscript will be made available upon acceptance by PLoS One.</b>
DOI: 10.6084/m9.figshare.5406466
title: Station (North)

description: Data collected from "north" stationary monitor.
DOI: 10.6084/m9.figshare.5406457
title: Station (South)

description: Data from "south" stationary monitor.
DOI: 10.6084/m9.figshare.5406466.v1
title: Station (North)

description: Data collected from "north" stationary monitor.
DOI: 10.6084/m9.figshare.5406472.v1
title: Driving Windows Up

description: Data collected from driving with windows up
DOI: 10.6084/m9.figshare.5406787.v11
title: Succinic acid treatment of SCA1 transgenic mice

description: Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitochondrial oxidative phosphorylation (OXPHOS) deficits in cerebellar tissue of a Purkinje cell-driven spinocerebellar ataxia type 1 (SCA1) mouse. Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase). Complex I genes are upregulated at the time of symptom onset and upregulation persists into late stage disease; yet, functional assembly of complex I macromolecules are diminished and oxygen respiration through complex I is reduced. Acute treatment of postsymptomatic SCA1 mice with succinic acid, a complex II (succinate dehydrogenase) electron donor to bypass complex I dysfunction, ameliorated cerebellar OXPHOS dysfunction, reduced cerebellar pathology and improved behavior. Thus, treatment with succinic acid shows promise as a therapeutic adjuvant in neurodegenerative ataxias, and warrants further investigation. <b><br></b><b>All data from this manuscript will be made available upon acceptance by PLoS One.</b>
DOI: 10.6084/m9.figshare.5406457.v1
title: Station (South)

description: Data from "south" stationary monitor.
DOI: 10.6084/m9.figshare.5406403
title: HAJ3317aORIGINALDATASET.sav

description: Hajj 2012 SPSS data set prior to data-cleaning or processing.<br>
DOI: 10.6084/m9.figshare.5406397
title: Experiment paradigm and raw images

description: Matlab script for experiment (loads images.mat and make use of PTB 3)
DOI: 10.6084/m9.figshare.5406397.v1
title: Experiment paradigm and raw images

description: Matlab script for experiment (loads images.mat and make use of PTB 3)
DOI: 10.6084/m9.figshare.5406382
title: Supplementary Material for: Warfarin Use and Increased Mortality in End-Stage Renal Disease

description: <b><i>Background:</i></b> Controversy exists regarding the benefits and risks of warfarin therapy in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. In this study, we assessed mortality and cardiovascular outcomes associated with warfarin treatment in patients with stages 3-5 CKD and ESRD admitted to the University of California-Irvine Medical Center. <b><i>Methods:</i></b> In a retrospective matched cohort study, we identified 59 adult patients with stages 3-6 CKD initiated on warfarin during the period 2011-2013, and 144 patients with stages 3-6 CKD who had indications for anticoagulation therapy but were not initiated on warfarin. All-cause mortality risk associated with warfarin treatment was estimated using Cox proportional hazard regression analysis, and the risk of significant bleeding and major adverse cardiovascular events were analyzed with Poisson regression analysis. Adjustment models were used to account for age, gender, diabetes mellitus, use of antiplatelet agents, and preexisting cardiovascular disease, and stratified by pre-dialysis CKD stages 3-5 vs. ESRD. <b><i>Findings:</i></b> During 5.8 years of follow-up, unadjusted mortality risk was higher in CKD patients on warfarin therapy (hazard ratio [HR] 2.34 with 95% CI 1.25-4.39; <i>p</i> &lt; 0.01). After multivariate adjustment and stratification by CKD stage, the mortality risk remained significant in ESRD patients receiving warfarin (HR 6.62 with 95% CI 2.56-17.16; <i>p</i> &lt; 0.001). Furthermore, adjusted rates of significant bleeding (incident rate ratio, IRR 3.57 with 95% CI 1.51-8.45; <i>p</i> &lt; 0.01) and myocardial infarction (IRR 4.20 with 95% CI 1.78-9.91; <i>p</i> &lt; 0.01) were higher among warfarin users. No differences in rates of ischemic or hemorrhagic strokes were found between the 2 groups. <b><i>Conclusions:</i></b> Warfarin use was associated with several-fold higher risk of death, bleeding, and myocardial infarction in dialysis patients. If additional studies suggest similar associations, the use of warfarin in dialysis patients warrants immediate reconsideration.
DOI: 10.6084/m9.figshare.5406355
title: PlasmidTron: assembling the cause of phenotypes from NGS data

description: <i>PlasmidTron utilises the phenotypic data normally available in bacterial population studies, such as antibiograms, virulence factors, or geographic information, to identify sequences that are likely to represent MGEs linked to the phenotype. </i><br>
DOI: 10.6084/m9.figshare.5406343
title: Supplementary materials for: Sidorov et al., 2018

description: <b>Supplementary materials for: Sidorov D.A., Taylor S.J., Sharina S.N., Gontcharov A.A. 2018. </b><b>Zenkevitchiidae fam. nov. (Crustacea: Gammaroidea), with description of new subterranean amphipods from extremely deep cave habitats. Journal of Natural History 52(23-24): 1509-1535. DOI:10.1080/00222933.2018.1482017</b><b><br></b> SUPPLEMENTARY FILE 1. Table 1. Species included in the phylogenetic analyses with geographic origin, nominal group, accession numbers of the sequences and sampling date. SUPPLEMENTARY FILE 2. FASTA file for LSU-rDNA sequences alignment.
DOI: 10.6084/m9.figshare.5406349
title: Supplementary Material for: Feasibility and Effectiveness of Intervention Programmes Integrating Functional Exercise into Daily Life of Older Adults: A Systematic Review

description: <b><i>Background:</i></b> Traditionally, exercise programmes for improving functional performance and reducing falls are organised as structured sessions. An alternative approach of integrating functional exercises into everyday tasks has emerged in recent years. <b><i>Objectives:</i></b> Summarising the current evidence for the feasibility and effectiveness of interventions integrating functional exercise into daily life. <b><i>Methods:</i></b> A systematic literature search was conducted including articles based on the following criteria: (1) individuals ≥60 years; (2) intervention studies of randomised controlled trials (RCTs) and non-randomised studies (NRS); (3) using a lifestyle-integrated approach; (4) using functional exercises to improve strength, balance, or physical functioning; and (5) reporting outcomes on feasibility and/or effectiveness. Methodological quality of RCTs was evaluated using the PEDro scale. <b><i>Results:</i></b> Of 4,415 articles identified from 6 databases, 14 (6 RCTs) met the inclusion criteria. RCT quality was moderate to good. Intervention concepts included (1) the Lifestyle-integrated Functional Exercise (LiFE) programme integrating exercises into everyday activities and (2) combined programmes using integrated and structured training. Three RCTs evaluated LiFE in community dwellers and reported significantly improved balance, strength, and functional performance compared with controls receiving either no intervention, or low-intensity exercise, or structured exercise. Two of these RCTs reported a significant reduction in fall rate compared with controls receiving either no intervention or low-intensity exercise. Three RCTs compared combined programmes with usual care in institutionalised settings and reported improvements for some (balance, functional performance), but not all (strength, falls) outcomes. NRS showed behavioural change related to LiFE and feasibility in more impaired populations. One NRS comparing a combined home-based programme to a gym-based programme reported greater sustainability of effects in the combined programme. <b><i>Conclusions:</i></b> This review provides evidence for the effectiveness of integrated training for improving motor performances in older adults. Single studies suggest advantages of integrated compared with structured training. Combined programmes are positively evaluated in institutionalised settings, while little evidence exists in other populations. In summary, the approach of integrating functional exercise into daily life represents a promising alternative or complement to structured exercise programmes. However, more RCTs are needed to evaluate this concept in different target populations and the potential for inducing behavioural change.
DOI: 10.6084/m9.figshare.5406355.v1
title: PlasmidTron: assembling the cause of phenotypes from NGS data

description: <i>PlasmidTron utilises the phenotypic data normally available in bacterial population studies, such as antibiograms, virulence factors, or geographic information, to identify sequences that are likely to represent MGEs linked to the phenotype. </i><br>
DOI: 10.6084/m9.figshare.5406316
title: Supplementary Material for: Ring Chromosome 17 Not Involving the Miller-Dieker Region: A Case with Drug-Resistant Epilepsy

description: Chromosomal abnormalities are often identified in people with neurodevelopmental disorders including intellectual disability, autism, and epilepsy. Ring chromosomes, which usually involve gene copy number loss, are formed by fusion of subtelomeric or telomeric chromosomal regions. Some ring chromosomes, including ring 14, 17, and 20, are strongly associated with seizure disorders. We report an individual with a ring chromosome 17, r(17)(p13.3q25.3), with a terminal 17q25.3 deletion and no short arm copy number loss, and with a phenotype characterized by intellectual disability and drug-resistant epilepsy, including a propensity for nonconvulsive status epilepticus.
DOI: 10.6084/m9.figshare.5406343.v1
title: Supplementary materials for: Sidorov et al.

description: <b>Supplementary materials for: Sidorov et al., </b><b>Zenkevitchiidae fam. nov. (Crustacea: Gammaroidea), with description of new subterranean amphipods from extremely deep cave habitats</b> SUPPLEMENTARY FILE 1. Table 1. Species included in the phylogenetic analyses with geographic origin, nominal group, accession numbers of the sequences and sampling date. SUPPLEMENTARY FILE 2. FASTA file for LSU-rDNA sequences alignment.
DOI: 10.6084/m9.figshare.5406289
title: Radiolabelling experiment

description: Production of tracer for magnetic / radioactive sentinel lymph node mapping.<br>
DOI: 10.6084/m9.figshare.5406310
title: Liu et al Compound 14 LSD data file

description: An input dataset for the computer-assisted structure elucidation program LSD (logic for structure determination, http://eos.univ-reims.fr/LSD/index_ENG.html) by Jean-Marc Nuzillard, U Reims. The dataset was created following the data reported for compound #14 in p.p1 {margin: 0.0px 0.0px 12.0px 20.0px; text-indent: -20.0px; font: 12.0px Helvetica} Liu R, Su Y, Yang J, Wang A (2017) Polyprenylated acylphloroglucinols from Hypericum scabrum. Phytochemistry 142:38–50. doi: 10.1016/j.phytochem.2017.06.011LSD yields 2 solutions for this dataset.
DOI: 10.6084/m9.figshare.5406316.v1
title: Supplementary Material for: Ring Chromosome 17 Not Involving the Miller-Dieker Region: A Case with Drug-Resistant Epilepsy

description: Chromosomal abnormalities are often identified in people with neurodevelopmental disorders including intellectual disability, autism, and epilepsy. Ring chromosomes, which usually involve gene copy number loss, are formed by fusion of subtelomeric or telomeric chromosomal regions. Some ring chromosomes, including ring 14, 17, and 20, are strongly associated with seizure disorders. We report an individual with a ring chromosome 17, r(17)(p13.3q25.3), with a terminal 17q25.3 deletion and no short arm copy number loss, and with a phenotype characterized by intellectual disability and drug-resistant epilepsy, including a propensity for nonconvulsive status epilepticus.
DOI: 10.6084/m9.figshare.5406289.v1
title: Radiolabelling experiment

description: Production of tracer for magnetic / radioactive sentinel lymph node mapping.<br>
DOI: 10.6084/m9.figshare.5406274
title: Opsoclonus-myoclonus syndrome following long-term use of cyclosporine

description: <b>Background:</b> Cyclosporine A (CsA) is a widely used immunosuppressive agent that may provoke unexpected neurologic complications. The mechanism is unclear and variable intervals have been reported between CsA administration and onset of the related side effects. Here, we describe a case of delayed-onset CsA neurotoxicity presenting as opsoclonus-myoclonus syndrome (OMS). <b>Case details:</b> A 37-year-old woman with a two-week period of opsoclonus and upper extremity myoclonus was admitted to our hospital. The patient had been taking CsA for 17 years after receiving a kidney transplant. Further evaluation did not reveal any other abnormalities. Seven days after switching from CsA to tacrolimus, in the absence of additional immune-modulating therapy, her neurologic symptoms improved considerably. <b>Conclusion:</b> This is the case of delayed, long-term complications of CsA presenting as OMS. Symptoms resolved by substituting CsA with another immunomodulating drug. The etiology of the neurologic complications may involve paradoxically-enhanced delayed-type hypersensitivity.
DOI: 10.6084/m9.figshare.5406343.v3
title: Supplementary materials for: Sidorov et al., 2018

description: <b>Supplementary materials for: Sidorov D.A., Taylor S.J., Sharina S.N., Gontcharov A.A. 2018. </b><b>Zenkevitchiidae fam. nov. (Crustacea: Gammaroidea), with description of new subterranean amphipods from extremely deep cave habitats. Journal of Natural History 52(23-24): 1509-1535. DOI:10.1080/00222933.2018.1482017</b><b><br></b> SUPPLEMENTARY FILE 1. Table 1. Species included in the phylogenetic analyses with geographic origin, nominal group, accession numbers of the sequences and sampling date. SUPPLEMENTARY FILE 2. FASTA file for LSU-rDNA sequences alignment.
DOI: 10.6084/m9.figshare.5406310.v1
title: Liu et al Compound 14 LSD data file

description: An input dataset for the computer-assisted structure elucidation program LSD (logic for structure determination, http://eos.univ-reims.fr/LSD/index_ENG.html) by Jean-Marc Nuzillard, U Reims. The dataset was created following the data reported for compound #14 in p.p1 {margin: 0.0px 0.0px 12.0px 20.0px; text-indent: -20.0px; font: 12.0px Helvetica} Liu R, Su Y, Yang J, Wang A (2017) Polyprenylated acylphloroglucinols from Hypericum scabrum. Phytochemistry 142:38–50. doi: 10.1016/j.phytochem.2017.06.011LSD yields 2 solutions for this dataset.
DOI: 10.6084/m9.figshare.5406343.v2
title: Supplementary materials for: Sidorov et al.

description: <b>Supplementary materials for: Sidorov et al., </b><b>Zenkevitchiidae fam. nov. (Crustacea: Gammaroidea), with description of new subterranean amphipods from extremely deep cave habitats</b> SUPPLEMENTARY FILE 1. Table 1. Species included in the phylogenetic analyses with geographic origin, nominal group, accession numbers of the sequences and sampling date. SUPPLEMENTARY FILE 2. FASTA file for LSU-rDNA sequences alignment.