cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23359229.v1
title: Exosomal miR-18a-5p promotes EMT and metastasis of NPC cells via targeting BTG3 and activating the Wnt/β-catenin signaling pathway

description: This study investigated the underlying mechanism of miR-18a-5p regulating the proliferation, invasion, and metastasis of nasopharyngeal carcinoma (NPC) cells in vitro and in vivo to indicate the pathogenesis of NPC. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was utilized to determine miR-18a-5p expression level in NPC tissues and cell lines. Besides, 2,5-diphenyl-2 H-tetrazolium bromide (MTT) and colony formation assays were employed to detect the effect of miR-18a-5p expression level on NPC cell proliferation. Wound healing and Transwell assays were utilized to detect the effect of miR-18a-5p on NPC cell invasion and migration. The expression levels of epithelial-mesenchymal transition (EMT)-related proteins (Vimentin, N-cadherin, and E-cadherin) were identified by Western blot assay. After collecting exosomes from CNE-2 cells, it was found that exosomal miR-18a-5p secreted from NPC cells promoted NPC cell proliferation, migration, invasion, and EMT, whereas inhibition of miR-18a-5p expression level led to the opposite results. The dual-luciferase reporter assay showed that BTG anti-proliferation factor 3 (BTG3) was the target gene of miR-18a-5p, and BTG3 could overturn the effect of miR-18a-5p on NPC cells. Xenograft mouse model of NPC nude mice showed that miR-18a-5p promoted NPC growth and metastasis in vivo. This study revealed that exosomal miR-18a-5p derived from NPC cells promoted angiogenesis via targeting BTG3 and activating the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.12873575
title: Additional file 2 of Genomic characteristics of cattle copy number variations

description: Additional file 2:Supplemental Material file. Table S6. Gene contents of cattle CNV regions. (XLS 454 KB)
DOI: 10.6084/m9.figshare.12873575.v1
title: Additional file 2 of Genomic characteristics of cattle copy number variations

description: Additional file 2:Supplemental Material file. Table S6. Gene contents of cattle CNV regions. (XLS 454 KB)
DOI: 10.6084/m9.figshare.19687024
title: Additional file 6 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 6: Supplemental Table 6. Bacterial species that differed significantly between the IMN patients and HC by LEfSe.
DOI: 10.6084/m9.figshare.9203459.v1
title: Reconstruction of nearshore chemical conditions in the Mesoproterozoic: evidence from red and grey beds of the Yangzhuang formation, North China Craton

description: Mesoproterozoic red beds near ancient coasts have not aroused extensive interest. A new geochemical study of the alternating red and grey dolostones from the Yangzhuang Formation provides a better understanding of the redox conditions of nearshore sedimentary environments. In this contribution, whole-rock samples are characterized by positive correlations of rare earth elements (REE) vs. Th and Fe<sub>T</sub> vs. Th and flat-type REE distribution patterns, indicating massive terrigenous input, which is considered to be inherited from felsic rocks. Relatively high (Fe<sub>mag</sub>+Fe<sub>ox</sub>)/Fe<sub>T</sub> and Fe<sup>3+</sup>/Fe<sup>2+</sup> ratios in red beds indicate more oxidized conditions in supratidal environments compared with the lower oxygen contents in intertidal environments. Under these two distinct chemical sedimentary conditions, acetic acid-leached red and grey samples both have HREE-depleted distributions, suggesting significant freshwater invasion. Moreover, limited terrigenous redox-sensitive elements (RSEs) can reach the coast where the red beds are deposited, whereas relatively high RSE enrichment factors originating from shallow oceans are recorded in grey beds. In the Mesoproterozoic, limited oxidative weathering, shallow seawater desalination, and low organic production occurred near the coast. Meanwhile, a prolonged period of low Mo and U availability preserved in carbonate minerals confirmed that marine oxygen levels failed to satisfy the deposition of offshore red beds. During the regression, potentially exposed sediments connected to atmospheric oxygen guaranteed the oxidation of iron and the formation of red beds, and these events were coupled with negative δ<sup>13</sup>C<sub>carb</sub> shifts in the Yanliao rift zone.
DOI: 10.6084/m9.figshare.19689186.v1
title: Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis

description: Liver fibrosis occurs following inflammation triggered by the integrated actions of activated liver-resident macrophages (Kupffer cells) and hepatic stellate cells (HSCs), and the multiplicity of these mechanisms complicates drug therapy. Here, we demonstrate that the selective bromodomain and extra-terminal (BET) bromodomain inhibitor compound38 can block both the Janus kinase-signal transducer and activator of transcription and mitogen-activated protein kinase signaling pathways in macrophages, which decreased their secretion of proinflammatory cytokines in a dose-dependent manner. The inactivation of macrophages attenuated lipopolysaccharide-induced injurious inflammation concurrent with a reduction in F4/80+ cells, proinflammatory cytokine levels, and neutrophil infiltration. Moreover, compound 38 inhibited the Wnt/β-catenin and transforming growth factor-beta/SMAD signaling pathways to abolish the activation of HSCs. <i>In vivo</i>, compound 38 significantly decreased the collagen deposition and fibrotic area of a CCl<sub>4</sub>-induced liver fibrosis model, and restored the deficiency of activated HSCs and the upregulation of liver inflammation. These results highlight the potential role of compound 38 in treating liver fibrosis considering its simultaneous inhibitory effects on liver inflammation and related fibrosis.
DOI: 10.25549/one-ouc17554279
title: Mattachine Society, ONE, Incorporated correspondence (1952-1960)
DOI: 10.6084/m9.figshare.23359229
title: Exosomal miR-18a-5p promotes EMT and metastasis of NPC cells via targeting BTG3 and activating the Wnt/β-catenin signaling pathway

description: This study investigated the underlying mechanism of miR-18a-5p regulating the proliferation, invasion, and metastasis of nasopharyngeal carcinoma (NPC) cells in vitro and in vivo to indicate the pathogenesis of NPC. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was utilized to determine miR-18a-5p expression level in NPC tissues and cell lines. Besides, 2,5-diphenyl-2 H-tetrazolium bromide (MTT) and colony formation assays were employed to detect the effect of miR-18a-5p expression level on NPC cell proliferation. Wound healing and Transwell assays were utilized to detect the effect of miR-18a-5p on NPC cell invasion and migration. The expression levels of epithelial-mesenchymal transition (EMT)-related proteins (Vimentin, N-cadherin, and E-cadherin) were identified by Western blot assay. After collecting exosomes from CNE-2 cells, it was found that exosomal miR-18a-5p secreted from NPC cells promoted NPC cell proliferation, migration, invasion, and EMT, whereas inhibition of miR-18a-5p expression level led to the opposite results. The dual-luciferase reporter assay showed that BTG anti-proliferation factor 3 (BTG3) was the target gene of miR-18a-5p, and BTG3 could overturn the effect of miR-18a-5p on NPC cells. Xenograft mouse model of NPC nude mice showed that miR-18a-5p promoted NPC growth and metastasis in vivo. This study revealed that exosomal miR-18a-5p derived from NPC cells promoted angiogenesis via targeting BTG3 and activating the Wnt/β-catenin signaling pathway.
DOI: 10.25549/one-ouc17554280
title: Mattachine Society, ONE, Incorporated correspondence (1952-1960)
DOI: 10.25549/one-ouc17554281
title: Mattachine Society, reports given at ONE, Incorporated Midwinter Institute (1956)
DOI: 10.6084/m9.figshare.12873578
title: Additional file 3 of Genomic characteristics of cattle copy number variations

description: Additional file 3:Supplemental Material file. Table S11. Cattle CNV regions overlap with genomic regions under positive selection, human orthologous OMIM genes and cattle QTLs. (XLS 332 KB)
DOI: 10.6084/m9.figshare.12873578.v1
title: Additional file 3 of Genomic characteristics of cattle copy number variations

description: Additional file 3:Supplemental Material file. Table S11. Cattle CNV regions overlap with genomic regions under positive selection, human orthologous OMIM genes and cattle QTLs. (XLS 332 KB)
DOI: 10.6084/m9.figshare.17065843
title: Additional file 1 of Clinical application of robotic orthopedic surgery: a bibliometric study

description: Additional file 1. Top 30 cited papers on robotic orthopedic surgery. The research hotspot of robotic orthopedic surgery during 2000 − 2004, 2005 − 2009, 2010 − 2014, and 2015 − 2019.
DOI: 10.6084/m9.figshare.7635305
title: Additional file 1: of A high-density genetic map of Schima superba based on its chromosomal characteristics

description: Table S1. Number of clean GBS reads per sample (XLSX 12 kb)
DOI: 10.25549/one-ouc17554282
title: Mattachine Society, ONE, Incorporated correspondence (1952-1960)
DOI: 10.6084/m9.figshare.17065843.v1
title: Additional file 1 of Clinical application of robotic orthopedic surgery: a bibliometric study

description: Additional file 1. Top 30 cited papers on robotic orthopedic surgery. The research hotspot of robotic orthopedic surgery during 2000 − 2004, 2005 − 2009, 2010 − 2014, and 2015 − 2019.
DOI: 10.25549/one-ouc17554283
title: Mattachine Society, ONE, Incorporated correspondence (1960-1963)
DOI: 10.25549/one-ouc17554285
title: Mattachine Society, ONE, Incorporated correspondence (1952-1960)
DOI: 10.25549/one-ouc17554284
title: Mattachine Society, ONE, Incorporated correspondence (1952-1960)
DOI: 10.25549/one-ouc17554286
title: Mattachine Society, ONE, Incorporated correspondence (1952-1960)
DOI: 10.6084/m9.figshare.19687009
title: Additional file 1 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 1: Supplemental Table 1. Baseline characteristics of participants.
DOI: 10.25549/one-ouc17554287
title: Mattachine Society, reports given at ONE, Incorporated Midwinter Institute (1956)
DOI: 10.25549/one-ouc17554288
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.6084/m9.figshare.19687009.v1
title: Additional file 1 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 1: Supplemental Table 1. Baseline characteristics of participants.
DOI: 10.25549/one-ouc17554292
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554289
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.6084/m9.figshare.12349355.v1
title: Probiotics supplementation improves hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes mellitus: An update of meta-analysis

description: <b>Background:</b> Although many studies have shown that consumption of probiotics is relevant to diabetes, the effects of probiotics improves clinical outcomes in type 2 diabetes have yielded conflicting results. The aim of this meta-analysis was conducted to assess the effects of probiotics supplementation on glycemic, blood lipids, pressure and inflammatory control in type 2 diabetes. <b>Methods:</b> PubMed, Web of science, Embase and the Cochrane Library databases were searched for relevant studies from February 2015 up to Janurary 2020, with no language restrictions. The pooled results were calculated with the use of a random-effects model to assess the impact of supplemental probiotics on glycemic, blood lipids, pressure and inflammatory control in type 2 diabetes. Additionally, subgroup analysis was conducted based on patients age, body mass index (BMI), country and duration of the probiotics supplement, respectively. <b>Results:</b> 13 studies were included in this meta-analysis, involving a total of 818 participants in 8 countries. Overall, compared with control groups, the subjects who received multiple species of probiotics had a statistically significant reduction in fasting blood sugar (FBS), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and tumor necrosis factor (TNF) -α [standardized mean difference (SMD): −0.89 mg/Dl, 95% CI: −1.66, −0.12 mg/dL; SMD: −0.43, 95% CI: −0.63, −0.23; SMD: −0.19 mg/dL, 95% CI: −0.36, −0.01 mg/dL; SMD: −0.23 mg/dL, 95% CI: −0.40, −0.05 mg/dL; SMD: −5.61 mmHg, 95% CI: −9.78, −1.45 mmHg; SMD: −3.41 mmHg, 95% CI: −6.12, −0.69 mmHg; and SMD: 6.92 pg/ml, 95% CI: 5.95, 7.89 pg/ml, respectively]. However, the subjects who received single-species of probiotic or probiotic with co-supplements in food only changed FBS, HOMA-IR, DBP and TG levels. Moreover, subgroup analyses revealed that the effects of probiotics supplementation on FBS, HMOA-IR, SBP and DBP are significantly influenced by patients age, body mass index (BMI), country and duration of the probiotics supplement. <b>Conclusion:</b> Our analysis revealed that glycemic, lipids, blood pressure and inflammation indicators are significantly improved by probiotic supplementation, particularly the subjects who ages ≤ 55, baseline BMI&lt; 30 kg/m<sup>2</sup>, duration of intervention more than 8 weeks, and received multiple species probiotic.
DOI: 10.25549/one-ouc17554293
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.6084/m9.figshare.12873569.v2
title: Additional file of Genomic characteristics of cattle copy number variations

description: Additional file of Genomic characteristics of cattle copy number variations
DOI: 10.6084/m9.figshare.12349355
title: Probiotics supplementation improves hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes mellitus: An update of meta-analysis

description: <b>Background:</b> Although many studies have shown that consumption of probiotics is relevant to diabetes, the effects of probiotics improves clinical outcomes in type 2 diabetes have yielded conflicting results. The aim of this meta-analysis was conducted to assess the effects of probiotics supplementation on glycemic, blood lipids, pressure and inflammatory control in type 2 diabetes. <b>Methods:</b> PubMed, Web of science, Embase and the Cochrane Library databases were searched for relevant studies from February 2015 up to Janurary 2020, with no language restrictions. The pooled results were calculated with the use of a random-effects model to assess the impact of supplemental probiotics on glycemic, blood lipids, pressure and inflammatory control in type 2 diabetes. Additionally, subgroup analysis was conducted based on patients age, body mass index (BMI), country and duration of the probiotics supplement, respectively. <b>Results:</b> 13 studies were included in this meta-analysis, involving a total of 818 participants in 8 countries. Overall, compared with control groups, the subjects who received multiple species of probiotics had a statistically significant reduction in fasting blood sugar (FBS), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and tumor necrosis factor (TNF) -α [standardized mean difference (SMD): −0.89 mg/Dl, 95% CI: −1.66, −0.12 mg/dL; SMD: −0.43, 95% CI: −0.63, −0.23; SMD: −0.19 mg/dL, 95% CI: −0.36, −0.01 mg/dL; SMD: −0.23 mg/dL, 95% CI: −0.40, −0.05 mg/dL; SMD: −5.61 mmHg, 95% CI: −9.78, −1.45 mmHg; SMD: −3.41 mmHg, 95% CI: −6.12, −0.69 mmHg; and SMD: 6.92 pg/ml, 95% CI: 5.95, 7.89 pg/ml, respectively]. However, the subjects who received single-species of probiotic or probiotic with co-supplements in food only changed FBS, HOMA-IR, DBP and TG levels. Moreover, subgroup analyses revealed that the effects of probiotics supplementation on FBS, HMOA-IR, SBP and DBP are significantly influenced by patients age, body mass index (BMI), country and duration of the probiotics supplement. <b>Conclusion:</b> Our analysis revealed that glycemic, lipids, blood pressure and inflammation indicators are significantly improved by probiotic supplementation, particularly the subjects who ages ≤ 55, baseline BMI&lt; 30 kg/m<sup>2</sup>, duration of intervention more than 8 weeks, and received multiple species probiotic.
DOI: 10.25549/one-ouc17554291
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554294
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.25549/one-ouc17555104
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.6084/m9.figshare.7635329.v1
title: Additional file 6: of A high-density genetic map of Schima superba based on its chromosomal characteristics

description: Table S5. QTL locations. (XLSX 19 kb)
DOI: 10.25549/one-ouc17554290
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554296
title: Mattachine Society, The Rejected television special (1961-1962)
DOI: 10.25549/one-ouc17555095
title: Mattachine Society, reports given at ONE, Incorporated Midwinter Institute (1956)
DOI: 10.25549/one-ouc17554297
title: Mattachine Society, proposal for confronting the Tenderloin problem (circa 1967)
DOI: 10.25549/one-ouc17554295
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554300
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.25549/one-ouc17554302
title: Mattachine Society, reports given at ONE, Incorporated Midwinter Institute (1956)
DOI: 10.25549/one-ouc17554298
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.25549/one-ouc17554303
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.25549/one-ouc17554299
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.25549/one-ouc17554460
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554301
title: Mattachine Society, Tavern Guild (1964-1967)
DOI: 10.6084/m9.figshare.19687012
title: Additional file 2 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 2: Supplemental Table 2. α-Diversity was assessed with 4 different diversity analysis methods.
DOI: 10.6084/m9.figshare.19687015
title: Additional file 3 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 3: Supplemental Table 3. Gut microbiota and clinical biomarkers evaluated by Spearson correlation analysis at the phylum level.
DOI: 10.25549/one-ouc17554304
title: Mattachine Society, The Rejected television special (1961-1962)
DOI: 10.25549/one-ouc17554307
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554305
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.6084/m9.figshare.19687018.v1
title: Additional file 4 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 4: Supplemental Table 4. Gut microbiota and clinical biomarkers evaluated by Spearson correlation analysis at the genus level.
DOI: 10.6084/m9.figshare.19687021.v1
title: Additional file 5 of Association of gut microbiota with idiopathic membranous nephropathy

description: Additional file 5: Supplemental Table 5. KEGG level 3 pathways of abundance changed intestinal flora.
DOI: 10.25549/one-ouc17554306
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554308
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.25549/one-ouc17554461
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554463
title: Mattachine Society, reports given at ONE, Incorporated Midwinter Institute (1956)
DOI: 10.25549/one-ouc17554464
title: Mattachine Society, proposal for confronting the Tenderloin problem (circa 1967)
DOI: 10.25549/one-ouc17554462
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.6084/m9.figshare.19689184.v1
title: Analysis of the different characteristics between omental preadipocytes and differentiated white adipocytes using bioinformatics methods

description: Obesity is emerging as an epidemiological issue, being associated with the onset and progress of various metabolism-related disorders. Obesity is characterized by the white adipose expansion, which encounters white adipocyte hypertrophy and hyperplasia. White adipocyte hyperplasia is defined as adipogenesis with the increase in the number of the white adipocytes from the preadipocytes. Adipogenesis contributes to distributing excess triglycerides among the smaller newly formed adipocytes, reducing the number of hypertrophic adipocytes and secreting anti-inflammatory factor. Therefore, adipogenesis is emerging as a new therapeutic target for the treatment of obesity. In the present study, for a better understanding of the contribution of the alteration of the omental differentiated white adipocytes to the systemic metabolic disorders, we downloaded the mRNA expression profiles from GEO database GSE1657, 328 differentially expressed genes (DEGs) were screened between the undifferentiated preadipocytes (UNDIF) and omental differentiated white adipocytes (DIF). The contributions of the upregulated and downregulated DEGs to the system were performed via the Gene Ontology (GO) analysis, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Protein–Protein Interaction (PPI) network, respectively. The potential contribution of the whole altered genes in the differentiated white adipocytes was explored with the performance of Gene Set Enrichment Analysis (GSEA), especially on the GO analysis, KEGG analysis, hallmark analysis, oncogenic analysis and related miRNA analysis. The output of the current study will shed light on the new targets for the treatment of obesity and obesity-related disorders.
DOI: 10.25549/one-ouc17554467
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.25549/one-ouc17554469
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.25549/one-ouc17554466
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.25549/one-ouc17554468
title: Mattachine Society, Tavern Guild (1964-1967)
DOI: 10.25549/one-ouc17554465
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.25549/one-ouc17554470
title: Mattachine Society, Society for Individual Rights (1964-1967)
DOI: 10.25549/one-ouc17554471
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554472
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554473
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554481
title: Mattachine Society, Tavern Guild (1964-1967)
DOI: 10.25549/one-ouc17554475
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554478
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17554480
title: Mattachine Society, Paul Coates incident (1953-1954)
DOI: 10.25549/one-ouc17554488
title: Mattachine Society, Police-Community Relations, San Francisco (1967)
DOI: 10.25549/one-ouc17556046
title: Mattachine Society, Long Beach (Harbor) Area Council correspondence and memoranda (1953-1956)
DOI: 10.25549/one-ouc17556047
title: Mattachine Society, Tavern Guild (1964-1967)
DOI: 10.25549/one-ouc17556049
title: Mattachine Society, Long Beach (Harbor) Area Council correspondence and memoranda (1953-1956)
DOI: 10.25549/one-ouc17556054
title: Mattachine Society, Wicker Research Studies, research project II (1959)
DOI: 10.25549/one-ouc17556178
title: Mattachine Society, Long Beach (Harbor) Area Council correspondence and memoranda (1953-1956)