DOI: 10.57760/sciencedb.07914
title: Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice
title: Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice

description: High-sugar and -fat diet (HSFD) have become a primary risk factor for diabetes, and diet intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study, the chemical composition of the aqueous extracts of the Stir-fried green tea (GT) and Congou black tea (BT) were compared. Moreover, their regulatory effects and potential mechanisms on the hepatic glycolipid metabolism and gut microbiota disorders in hyperglycemic mice were further explored. Our results show that GT or BT intervention had a preeminent regulatory effect on glycolipid metabolism. Moreover, they could significantly regulate the levels of serum metabolic signatures, the activities of key enzymes in liver glucose metabolism, and the expression of genes or proteins related to glycolipid metabolism via activating the IRS-1-PI3K/AKT-GLUT2 signaling pathway. Significantly, GT or BT administration adjusted the composition and diversity of the gut microbiota, mainly reflecting a significant increase in the abundance of beneficial bacteria (including Allobaculum, Lactobacillus, and Turicibacter) and reducing the abundance of harmful or conditionally pathogenic bacteria (mainly including Clostridiales and Bacteroides). Our results suggest that dietary supplementation with GT or BT could exert a practical anti-diabetic effect. Meanwhile, BT intervention showed a better regulation effect on glycolipid metabolism. This study reveals that GT and BT have excellent potential in developing anti-diabetic food.
description: High-sugar and -fat diet (HSFD) have become a primary risk factor for diabetes, and diet intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study, the chemical composition of the aqueous extracts of the Stir-fried green tea (GT) and Congou black tea (BT) were compared. Moreover, their regulatory effects and potential mechanisms on the hepatic glycolipid metabolism and gut microbiota disorders in hyperglycemic mice were further explored. Our results show that GT or BT intervention had a preeminent regulatory effect on glycolipid metabolism. Moreover, they could significantly regulate the levels of serum metabolic signatures, the activities of key enzymes in liver glucose metabolism, and the expression of genes or proteins related to glycolipid metabolism via activating the IRS-1-PI3K/AKT-GLUT2 signaling pathway. Significantly, GT or BT administration adjusted the composition and diversity of the gut microbiota, mainly reflecting a significant increase in the abundance of beneficial bacteria (including Allobaculum, Lactobacillus, and Turicibacter) and reducing the abundance of harmful or conditionally pathogenic bacteria (mainly including Clostridiales and Bacteroides). Our results suggest that dietary supplementation with GT or BT could exert a practical anti-diabetic effect. Meanwhile, BT intervention showed a better regulation effect on glycolipid metabolism. This study reveals that GT and BT have excellent potential in developing anti-diabetic food.