cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60645/bdc-6v20-9285
title: Cardiovascular Health Study (CHS) - Imaging

description: 
The [Cardiovascular Health Study](https://www.nhlbi.nih.gov/science/cardiovascular-health-study-chs) (CHS) is a prospective study of risk factors for development and progression of coronary heart disease (CHD) and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 

Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 

Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication, and mortality.
DOI: 10.60645/bdc-l8y3-n2fm
title: Studies of Left Ventricular Dysfunction (SOLVD-BioLINCC)

description: 
<u>Data Access NOTE</u>:<br>Please refer to the "Authorized Access" section below for information about how access to the data from this accession. Access differs from many other dbGaP accessions. 

<u>Objectives</u><br>This study was initiated in 1986, primarily to evaluate the effects of enalapril, an ACE inhibitor, on long-term mortality and major morbidity in a group of participants with left ventricular dysfunction. Two large separate trials were run concurrently as part of SOLVD: 1) a prevention trial of participants with low ejection fraction but no overt symptoms of CHF and, 2) a treatment trial of participants with low ejection fraction and symptoms of CHF. In addition, participants at selected sites were entered into substudies to evaluate the effect of enalapril on a number of intermediate outcomes such as right and left ventricular function and hemodynamics, LV mass and wall stress, hormones, arrhythmias, exercise capacity, and quality of life in subsets of participants. Lastly, a registry of 6,336 participants with congestive heart failure of LV dysfunction was designed to describe the clinical course of an unselected group of participants. 

<u>Background </u><br>Congestive Heart Failure (CHF) is a major and increasingly recognized public health problem. The recognition that participants with CHF often have elevated peripheral vascular resistance has led to the introduction of vasodilator therapy, which has emerged as an important component of its treatment. Of the vasodilators, the angiotensin-converting enzyme (ACE) inhibitors appeared to be the most promising. In 1985, little was known about the impact of any long-term drug treatment on survival. 

SOLVD Registry: The SOLVD Registry is a hospital-based observational study, conducted at selected SOLVD hospitals, of participants with at least moderate left-ventricular dysfunction (EF &#8804; 45%) and/or radiologically confirmed heart failure. It consists of a main study (n=6,273) and a substudy (n=898). Although there is overlap between the Registry and the SOLVD trials, the Registry sample is not a subset of SOLVD nor is it the pool of participants eligible for both trials. 

<u>Participants </u><br>A total of 2,569 participants were enrolled into the treatment study and 4,228 participants were enrolled in the prevention study. The dataset available through the NHLBI contains the prevention and treatment study data as well as the registry data. 

<u>Conclusions </u><br>In the prevention trial, a significant reduction in the incidence of heart failure and the rate of related hospitalizations was observed for participants in the enalapril arm. A statistically significant reduction in mortality was not observed in the enalapril treatment arm; however, there was a trend toward fewer total deaths and deaths due to cardiovascular causes among the enalapril participants (SOLVD Investigators, et al., 1992, PMID: [1463530](https://pubmed.ncbi.nlm.nih.gov/1463530/)).
DOI: 10.60645/bdc-886y-66sl
title: Multi-Ethnic Study of Atherosclerosis (Echocardiogram Image Repository)

description: 
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent. 

Echocardiogram Image Repository includes Echocardiogram Images performed during MESA Exam 6 conducted between 2016 and 2018.
DOI: 10.60645/bdc-qd7u-t48a
title: Multi-Ethnic Study of Atherosclerosis (Echocardiogram Image Repository)

description: 
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent. 

Echocardiogram Image Repository includes Echocardiogram Images performed during MESA Exam 6 conducted between 2016 and 2018.
DOI: 10.5517/cc49z9p
title: CCDC 128752: Experimental Crystal Structure Determination

description: Related Article: J.Kozisek, J.G.Diaz, M.Hvastijova, L.Jager|1997|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|53|703|doi:10.1107/S010827019700111X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60645/bdc-880c-t6xd
title: Multi-Ethnic Study of Atherosclerosis (Electrocardiogram Tracing Repository)

description: 
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent. 

Electrocardiogram Tracing Repository includes ECG tracings performed during MESA Exam 1 conducted between 2000 and 2002 and during MESA Exam 5 conducted between 2010 and 2012.
DOI: 10.15468/dl.sp55xb
title: Occurrence Download

description: A dataset listing the 9 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Inventaires Aéro Biodiversité - LFGI - Dijon Darois-Inventaires Aéro Biodiversité - LFGI - Vigie-Chiro 1"
 ]
}

 The dataset's 9 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016309-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/cc7sbht
title: CCDC 231926: Experimental Crystal Structure Determination

description: Related Article: Chengbing Ma, Wenguo Wang, Xiaofeng Zhang, Changneng Chen, Qiutian Liu, Hongping Zhu, Daizheng Liao, Licun Li|2004|Eur.J.Inorg.Chem.|2004|3522|doi:10.1002/ejic.200400166
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7sbjv
title: CCDC 231927: Experimental Crystal Structure Determination

description: Related Article: Chengbing Ma, Wenguo Wang, Xiaofeng Zhang, Changneng Chen, Qiutian Liu, Hongping Zhu, Daizheng Liao, Licun Li|2004|Eur.J.Inorg.Chem.|2004|3522|doi:10.1002/ejic.200400166
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60645/bdc-lc3e-p00n
title: Multi-Ethnic Study of Atherosclerosis (Electrocardiogram Tracing Repository)

description: 
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent. 

Electrocardiogram Tracing Repository includes ECG tracings performed during MESA Exam 1 conducted between 2000 and 2002 and during MESA Exam 5 conducted between 2010 and 2012.
DOI: 10.5517/cc7nswj
title: CCDC 228528: Experimental Crystal Structure Determination

description: Related Article: Jin-Mei Yang, Zhao-Hui Zhou, Hui Zhang, Hui-Lin Wan, Shi-Jie Lu|2005|Inorg.Chim.Acta|358|1841|doi:10.1016/j.ica.2004.12.011
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc9fhy4
title: CCDC 281106: Experimental Crystal Structure Determination

description: Related Article: V. MATHIVANAN, S. GOKUL RAJ, G. RAMESH KUMAR,T. RAGHAVALU, R. MOHAN, K. SURIYA KUMAR,M. KOVENDHAN, B. VARGHESE|2006|Main Group Chem.|5|191|doi:10.1080/10241220701456180
description: Related Article: Srinivasan Gokul Raj, Gubendiran Ramesh Kumar, Rajagopal Mohan, Ramasamy Jayavel
|2006|Acta Crystallogr.,Sect.E:Struct.Rep.Online|E62|o5|doi:10.1107/S1600536805038791
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60645/bdc-0fcm-0351
title: CONNECTS Master Protocol for Clinical Trials targeting Macro- and Micro-Immuno-Thrombosis, Vascular Hyperinflammation, and Hypercoagulability and Renin-Angiotensin-Aldosterone System (RAAS) in Hospitalized Patients with COVID-19 (ACTIV-4 Host Tissue)

description: 
ACTIV 4 Host Tissue is a shared-placebo clinical trial platform evaluating therapies targeting the host response to COVID-19 in hospitalized patients. The overarching goal of the platform was to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing progression to critical illness, multiorgan failure, or death. Our objective is to determine whether modulating the host tissue response improves clinical outcomes among patients with COVID-19. Three trials were implemented to investigate three agents: TXA-127, TRV-027, and Fostamatinib. These agents all impact the host tissue response in COVID-19 via a number of unique mechanisms, including potential beneficial effects on the RAAS system and formation of neutrophil extracellular traps (NETs). Each trial evaluated the efficacy of these agents' ability to impact the host tissue response and improve outcomes in patients hospitalized with COVID-19. We found no evidence that any of the three agents significantly improved clinical outcomes as measured by the primary outcome, oxygen free days through day 28.
DOI: 10.5517/cc1k1s8n
title: CCDC 1431681: Experimental Crystal Structure Determination

description: Related Article: Hassiba Bougueria, Souheyla Chetioui, Issam Boudraa, Abd el Kader Bouchoul, Salah Eddine Bouaoud|2013|Acta Crystallogr.,Sect.E:Struct.Rep.Online|69|1335|doi:10.1107/S1600536813020102
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccvvbff
title: CCDC 799875: Experimental Crystal Structure Determination

description: Related Article: Wei Xue, Bao-Ying Wang, Jie Zhu, Wei-Xiong Zhang, Yue-Biao Zhang, Hai-Xia Zhao, Xiao-Ming Chen|2011|Chem.Commun.|47|10233|doi:10.1039/c1cc12852c
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mg138
title: CCDC 2426559: Experimental Crystal Structure Determination

description: Related Article: Martina Landrini, Jefferson Guzmán, Nereida Hidalgo, Miguel Ángel Gaona, Juan José Moreno, Jesús Campos|2026|ChemistryEurope|4|e202500376|doi:10.1002/ceur.202500376
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2ml5r5
title: CCDC 2430547: Experimental Crystal Structure Determination

description: Related Article: Wen‐Hui Yang, Ying Tong, Chen Li, Ming‐Qi Yang, Jia‐Yao Feng, Dong‐Qing Yang, Xi‐Ni Luo, Guo‐Ping Ge, Jun‐Qi Zhang, Wen‐Ting Wei|2026|Adv.Synth.Catal.|368|e70217|doi:10.1002/adsc.70217
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mng1t
title: CCDC 2432726: Experimental Crystal Structure Determination

description: Related Article: Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao|2026|ChemistryEurope|4|e202500486|doi:10.1002/ceur.202500486
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mng3w
title: CCDC 2432728: Experimental Crystal Structure Determination

description: Related Article: Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao|2026|ChemistryEurope|4|e202500486|doi:10.1002/ceur.202500486
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nnyhs
title: CCDC 2462996: Experimental Crystal Structure Determination

description: Related Article: Ángel D. Álvarez-Castillo, Alexis Juárez-Morales, Dazaet Galicia-Badillo, Mauricio Maldonado-Domínguez, Ernesto Enríquez-Palacios, José M. Heredia-Peñaloza, Marcos Flores-Álamo, José L. Belmonte-Vázquez|2026|ChemPhotoChem|10|e202500262|doi:10.1002/cptc.202500262
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.60645/bdc-6eev-j21e
title: Beta-Blocker Evaluation in Survival Trial (BEST-BioLINCC)

description: 
**<u>Data Access NOTE:</u> **Please refer to the &#8220;Authorized Access&#8221; section below for information about how access to the data from this accession differs from many other dbGaP accessions. 

<u>Objectives </u><br>The Beta-Blocker Evaluation of Survival Trial was designed to determine whether bucindolol hydrochloride- a nonselective beta-adrenergic blocker and mild vasodilator- would reduce the rate of death from any cause among patients with advanced heart failure and to assess its effects in various subgroups defined by ethnic background and demographic criteria- specifically women and members of minority groups. 

<u>Background </u><br>Although beta-adrenergic-receptor antagonists reduce morbidity and Mortality in participants with mild-to-moderate chronic heart failure, their effort on survival in participants with more advanced heart failure is unknown. 

<u>Participants </u><br>There were 2,708 participants. 

<u>Conclusions </u><br>Bucindolol resulted in no significant overall survival benefit. (Krause-Steinrauf et al., 2001, PMID: [11386264](https://pubmed.ncbi.nlm.nih.gov/11386264/)).
DOI: 10.5517/ccdc.csd.cc2nnyjt
title: CCDC 2462997: Experimental Crystal Structure Determination

description: Related Article: Ángel D. Álvarez-Castillo, Alexis Juárez-Morales, Dazaet Galicia-Badillo, Mauricio Maldonado-Domínguez, Ernesto Enríquez-Palacios, José M. Heredia-Peñaloza, Marcos Flores-Álamo, José L. Belmonte-Vázquez|2026|ChemPhotoChem|10|e202500262|doi:10.1002/cptc.202500262
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nnykv
title: CCDC 2462998: Experimental Crystal Structure Determination

description: Related Article: Ángel D. Álvarez-Castillo, Alexis Juárez-Morales, Dazaet Galicia-Badillo, Mauricio Maldonado-Domínguez, Ernesto Enríquez-Palacios, José M. Heredia-Peñaloza, Marcos Flores-Álamo, José L. Belmonte-Vázquez|2026|ChemPhotoChem|10|e202500262|doi:10.1002/cptc.202500262
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nnylw
title: CCDC 2462999: Experimental Crystal Structure Determination

description: Related Article: Ángel D. Álvarez-Castillo, Alexis Juárez-Morales, Dazaet Galicia-Badillo, Mauricio Maldonado-Domínguez, Ernesto Enríquez-Palacios, José M. Heredia-Peñaloza, Marcos Flores-Álamo, José L. Belmonte-Vázquez|2026|ChemPhotoChem|10|e202500262|doi:10.1002/cptc.202500262
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2npdd5
title: CCDC 2463427: Experimental Crystal Structure Determination

description: Related Article: Ángel D. Álvarez-Castillo, Alexis Juárez-Morales, Dazaet Galicia-Badillo, Mauricio Maldonado-Domínguez, Ernesto Enríquez-Palacios, José M. Heredia-Peñaloza, Marcos Flores-Álamo, José L. Belmonte-Vázquez|2026|ChemPhotoChem|10|e202500262|doi:10.1002/cptc.202500262
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nq5yj
title: CCDC 2464188: Experimental Crystal Structure Determination

description: Related Article: Ji-Long Zou, Da-Yu Shi, Yi-Zhou Xiang, Li Zhang, Ping Tian, Qing-Hua Li|2026|Bioorg.Chem.|170||doi:10.1016/j.bioorg.2026.109531
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.