cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6967961
title: Changes observed in prostate biopsy practices in an inner city hospital with a high risk patient population following the 2012 USPSTF PSA screening recommendations

description: ABSTRACT Introduction: We compared characteristics of patients undergoing prostate biopsy in a high-risk inner city population before and after the 2012 USPSTF recommendation against PSA based prostate cancer screening to determine its effect on prostate biopsy practices. Materials and Methods: This was a retrospective study including patients who received biopsies after an abnormal PSA measurement from October 2008-December 2015. Patients with previously diagnosed prostate cancer were excluded. Chi-square tests of independence, two sample t-tests, Mann-Whitney U tests, and Fisher's exact tests were performed. Results: There were 202 and 208 patients in the pre-USPSTF and post-USPSTF recommendation cohorts, respectively. The post-USPSTF cohort had higher median PSA (7.8 versus 7.1ng/mL, p=0.05), greater proportion of patients who were black (96.6% versus 90.5%, p=0.01), and greater percentage of biopsy cores positive for disease (58% versus 29.5%, p&lt;0.001). Multivariable analysis supported that the increase in PSA was independent of the increase in the proportion of patients who were black. The proportion of patients who were classified as D’Amico intermediate and high-risk disease increased in the post-USPSTF cohort and approached statistical significance (70.1% versus 58.8%, p=0.12). Conclusions: Our study suggests that the USPSTF recommendations may have led to an increase in pre-biopsy PSA as well as greater volume of disease. Also, a greater proportion of patients were being classified with intermediate or high risk disease. While the clinical significance of these findings is unknown, what the data suggests is somewhat troubling. Future research should further examine these changes in a larger cohort as well as resultant long-term outcomes.
DOI: 10.6084/m9.figshare.6967958
title: Harmonization study of results between biochemical analyzers Labmax 240® and Labmax 240 Premium®

description: ABSTRACT Introduction: The harmonization of equipment is recommended in clinical laboratory practice aiming for the homogeneity of results when similar or equivalent analyzers are used to perform routine testing. Objectives: To conduct a study of equivalence between the biochemical analyzers Labmax 240® (E1) and Labmax 240 Premium® (E2) through the matching results and the statistical value analysis of dosages. Materials and methods: We evaluated tests with glucose, total cholesterol, triglycerides, uric acid, aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH), all with 40 repeated measurements, performed in both equipments. The Clinical and Laboratory Standards Institute (CLSI) EP09-3A protocol was used to conduct the comparison test between E1 and E2 equipment, with subsequent evaluation of the results for statistical analysis determining the Pearson correlation coefficient (r) and indexes comparison error with EP Evaluator® software. Results: Regarding the values of the Pearson correlation coefficient, all tests showed a strong correlation between equipment with r &gt; 0.989, except for the dosage of LDH (r = 0.982). This dosage failed not because the value of r, but due to the values obtained in the error index being larger than the total errors index allowed. Discussion: Compared to clinical criteria, the results of the analyzers are approximately equal, but this control process must be done continuously in order to prevent and track random errors within the laboratory routine. Conclusion: The process of harmonization of multiple devices that perform the same laboratory parameters is essential for ensuring quality and reliability of laboratory results and should be standardized and included in routine clinical analysis laboratories.
DOI: 10.6084/m9.figshare.6967961.v1
title: Changes observed in prostate biopsy practices in an inner city hospital with a high risk patient population following the 2012 USPSTF PSA screening recommendations

description: ABSTRACT Introduction: We compared characteristics of patients undergoing prostate biopsy in a high-risk inner city population before and after the 2012 USPSTF recommendation against PSA based prostate cancer screening to determine its effect on prostate biopsy practices. Materials and Methods: This was a retrospective study including patients who received biopsies after an abnormal PSA measurement from October 2008-December 2015. Patients with previously diagnosed prostate cancer were excluded. Chi-square tests of independence, two sample t-tests, Mann-Whitney U tests, and Fisher's exact tests were performed. Results: There were 202 and 208 patients in the pre-USPSTF and post-USPSTF recommendation cohorts, respectively. The post-USPSTF cohort had higher median PSA (7.8 versus 7.1ng/mL, p=0.05), greater proportion of patients who were black (96.6% versus 90.5%, p=0.01), and greater percentage of biopsy cores positive for disease (58% versus 29.5%, p&lt;0.001). Multivariable analysis supported that the increase in PSA was independent of the increase in the proportion of patients who were black. The proportion of patients who were classified as D’Amico intermediate and high-risk disease increased in the post-USPSTF cohort and approached statistical significance (70.1% versus 58.8%, p=0.12). Conclusions: Our study suggests that the USPSTF recommendations may have led to an increase in pre-biopsy PSA as well as greater volume of disease. Also, a greater proportion of patients were being classified with intermediate or high risk disease. While the clinical significance of these findings is unknown, what the data suggests is somewhat troubling. Future research should further examine these changes in a larger cohort as well as resultant long-term outcomes.
DOI: 10.6084/m9.figshare.6967955
title: Entropy in peri-urbanization: inequality in access to transport infrastructures in Tonalá, Mexico

description: Abstract Mobility in the peri-urban strips has been experiencing multifaceted allometric growth, manifested in infrastructures for primarily motorized transport systems, which are characterized by obvious transformations and morphological configurations that converge with the entropy in the city system. Although this is not exclusive of peripheries, this is where deficiencies and inadequacies for some are intensified and recalcitrant improvements for others. This paper reviews the physical conditions and access to mobility infrastructures in the southeast of the municipality of Tonalá, Jalisco-México. From a system approach, we performed a quasi-ethnographic exercise aided by photographic records and satellite images. The results suggest that the urban-territorial planning process is inequitable and does not represent the negentropic force necessary to regulate the thermodynamics related to the exercise of living the city. In other words, there has been a lack of systemic conception in the planning process, originating excessive costs and time in the peri-urban mobility.
DOI: 10.6084/m9.figshare.6967958.v1
title: Harmonization study of results between biochemical analyzers Labmax 240® and Labmax 240 Premium®

description: ABSTRACT Introduction: The harmonization of equipment is recommended in clinical laboratory practice aiming for the homogeneity of results when similar or equivalent analyzers are used to perform routine testing. Objectives: To conduct a study of equivalence between the biochemical analyzers Labmax 240® (E1) and Labmax 240 Premium® (E2) through the matching results and the statistical value analysis of dosages. Materials and methods: We evaluated tests with glucose, total cholesterol, triglycerides, uric acid, aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH), all with 40 repeated measurements, performed in both equipments. The Clinical and Laboratory Standards Institute (CLSI) EP09-3A protocol was used to conduct the comparison test between E1 and E2 equipment, with subsequent evaluation of the results for statistical analysis determining the Pearson correlation coefficient (r) and indexes comparison error with EP Evaluator® software. Results: Regarding the values of the Pearson correlation coefficient, all tests showed a strong correlation between equipment with r &gt; 0.989, except for the dosage of LDH (r = 0.982). This dosage failed not because the value of r, but due to the values obtained in the error index being larger than the total errors index allowed. Discussion: Compared to clinical criteria, the results of the analyzers are approximately equal, but this control process must be done continuously in order to prevent and track random errors within the laboratory routine. Conclusion: The process of harmonization of multiple devices that perform the same laboratory parameters is essential for ensuring quality and reliability of laboratory results and should be standardized and included in routine clinical analysis laboratories.
DOI: 10.6084/m9.figshare.6967952
title: Ureteroscopy and stone treatment in the elderly (≥70 years): prospective outcomes over 5- years with a review of literature

description: ABSTRACT Objective: To assess outcomes of ureteroscopy for treatment of stone disease in the elderly. Ureteroscopy (URS) is an increasingly popular treatment modality for urolithiasis and its applications are ever expanding with the development of newer technologies. Its feasibility and outcomes within the elderly population to our knowledge remain under-reported. Materials and Methods: We examined the patient demographics and surgical outcomes from our prospective database for patients ≥70 years who underwent URS for urolithiasis, in a 5-year period between March 2012 and December 2016. Results: A total of 110 consecutive patients underwent 121 procedures (1.1 procedure/patient) with a mean age of 77.2 years (range: 70-91 years). Stone location was in the kidney/ pelviureteric junction (PUJ) in 29%, ureter in 37% and in multiple locations in 34%. The initial and final stone free rate (SFR) was 88% and 97% respectively. While 73% were done as true day case procedures, 89% patients were discharged within 24 hours. Eleven patients (9%) underwent complications of which 10 were Clavien I/II including acute urinary retention, urinary tract infection, stent symptoms and pneumonia. One patient underwent Clavien IV complication where they needed intensive care unit admission for urosepsis but fully recovered and were discharged home subsequently. Conclusion: Ureteroscopy is a safe and effective method of managing urolithiasis in elderly patients. Although most patients are discharged within 24-hours, consideration needs to be made for patients where social circumstances can impact their discharge planning.
DOI: 10.6084/m9.figshare.6967952.v1
title: Ureteroscopy and stone treatment in the elderly (≥70 years): prospective outcomes over 5- years with a review of literature

description: ABSTRACT Objective: To assess outcomes of ureteroscopy for treatment of stone disease in the elderly. Ureteroscopy (URS) is an increasingly popular treatment modality for urolithiasis and its applications are ever expanding with the development of newer technologies. Its feasibility and outcomes within the elderly population to our knowledge remain under-reported. Materials and Methods: We examined the patient demographics and surgical outcomes from our prospective database for patients ≥70 years who underwent URS for urolithiasis, in a 5-year period between March 2012 and December 2016. Results: A total of 110 consecutive patients underwent 121 procedures (1.1 procedure/patient) with a mean age of 77.2 years (range: 70-91 years). Stone location was in the kidney/ pelviureteric junction (PUJ) in 29%, ureter in 37% and in multiple locations in 34%. The initial and final stone free rate (SFR) was 88% and 97% respectively. While 73% were done as true day case procedures, 89% patients were discharged within 24 hours. Eleven patients (9%) underwent complications of which 10 were Clavien I/II including acute urinary retention, urinary tract infection, stent symptoms and pneumonia. One patient underwent Clavien IV complication where they needed intensive care unit admission for urosepsis but fully recovered and were discharged home subsequently. Conclusion: Ureteroscopy is a safe and effective method of managing urolithiasis in elderly patients. Although most patients are discharged within 24-hours, consideration needs to be made for patients where social circumstances can impact their discharge planning.
DOI: 10.6084/m9.figshare.6967955.v1
title: Entropy in peri-urbanization: inequality in access to transport infrastructures in Tonalá, Mexico

description: Abstract Mobility in the peri-urban strips has been experiencing multifaceted allometric growth, manifested in infrastructures for primarily motorized transport systems, which are characterized by obvious transformations and morphological configurations that converge with the entropy in the city system. Although this is not exclusive of peripheries, this is where deficiencies and inadequacies for some are intensified and recalcitrant improvements for others. This paper reviews the physical conditions and access to mobility infrastructures in the southeast of the municipality of Tonalá, Jalisco-México. From a system approach, we performed a quasi-ethnographic exercise aided by photographic records and satellite images. The results suggest that the urban-territorial planning process is inequitable and does not represent the negentropic force necessary to regulate the thermodynamics related to the exercise of living the city. In other words, there has been a lack of systemic conception in the planning process, originating excessive costs and time in the peri-urban mobility.
DOI: 10.6084/m9.figshare.6967949
title: Contract inspecting of outsourced service: challenges for public universities

description: Abstract Contract inspecting in public management, though essential for the functioning operation of projects and programs, have not been given the same care and support other bidding procedures have. The contract inspectors are not an organically-structured group, and this hinders the utilization of conventional training. The role of contract inspectors in public universities requires heterogeneous skills and knowledge, including thorough knowledge of legislation and operational practices of maintaining efficient management policies that satisfy the public interest. This paper investigates the challenges faced by these professionals and analyzes the learning mechanisms associated to the inspecting activity. The methodological tool is based on the case study strategy, making use of structured interviews and document analysis. The results point to the existence of weaknesses in the inspection process, confirming the need to hone and develop the skills of public agents assigned to the monitoring of outsourced service contracts in the university in question.
DOI: 10.6084/m9.figshare.6967949.v1
title: Contract inspecting of outsourced service: challenges for public universities

description: Abstract Contract inspecting in public management, though essential for the functioning operation of projects and programs, have not been given the same care and support other bidding procedures have. The contract inspectors are not an organically-structured group, and this hinders the utilization of conventional training. The role of contract inspectors in public universities requires heterogeneous skills and knowledge, including thorough knowledge of legislation and operational practices of maintaining efficient management policies that satisfy the public interest. This paper investigates the challenges faced by these professionals and analyzes the learning mechanisms associated to the inspecting activity. The methodological tool is based on the case study strategy, making use of structured interviews and document analysis. The results point to the existence of weaknesses in the inspection process, confirming the need to hone and develop the skills of public agents assigned to the monitoring of outsourced service contracts in the university in question.
DOI: 10.6084/m9.figshare.6967943
title: CONCENTRATION AND SIZE OF AIRBORNE PARTICULATES IN WOODWORKING SHOPS

description: ABSTRACT Wood secondary processing operations generate large amounts of airborne particulates. Inhalation of this material can lead to the development of work-related respiratory diseases. The Brazilian legislation does not define threshold limit values for airborne wood particles, and local studies are required to provide a technical basis for establishing these limits by regulation. This study aimed to determine the concentration and size of airborne wood particles of Eucalyptus spp. in woodworking shops. Analysis of the concentration of airborne particles was carried out using a gravimetric sampling pump and collector filters. The size of airborne particles was determined using microscope slides and an optical microscope coupled to an image capture system. Air samples were collected near different machines (belt sander, table saw, and band saw) at five woodworking shops located in the state of Espírito Santo, Brazil. Of the three machines, the belt sander produced the most harmful type of particulate matter: the small size of these particles allows their deposition deep into the respiratory tract. Particulate matter was above the threshold limit value established by international standards. To prevent the risk of severe health effects, there is an urgent and imperative need to reduce worker exposure levels (by the use of collective and personal protective equipment) as well as for the implementation of specific regulations that define particulate exposure limits for the wood sector in Brazil.
DOI: 10.6084/m9.figshare.6967943.v1
title: CONCENTRATION AND SIZE OF AIRBORNE PARTICULATES IN WOODWORKING SHOPS

description: ABSTRACT Wood secondary processing operations generate large amounts of airborne particulates. Inhalation of this material can lead to the development of work-related respiratory diseases. The Brazilian legislation does not define threshold limit values for airborne wood particles, and local studies are required to provide a technical basis for establishing these limits by regulation. This study aimed to determine the concentration and size of airborne wood particles of Eucalyptus spp. in woodworking shops. Analysis of the concentration of airborne particles was carried out using a gravimetric sampling pump and collector filters. The size of airborne particles was determined using microscope slides and an optical microscope coupled to an image capture system. Air samples were collected near different machines (belt sander, table saw, and band saw) at five woodworking shops located in the state of Espírito Santo, Brazil. Of the three machines, the belt sander produced the most harmful type of particulate matter: the small size of these particles allows their deposition deep into the respiratory tract. Particulate matter was above the threshold limit value established by international standards. To prevent the risk of severe health effects, there is an urgent and imperative need to reduce worker exposure levels (by the use of collective and personal protective equipment) as well as for the implementation of specific regulations that define particulate exposure limits for the wood sector in Brazil.
DOI: 10.6084/m9.figshare.6967937
title: Pessoa’s Archive: a study about understandings and representations of archival manuscripts in the Casa Fernando Pessoa

description: ABSTRACT This article presents the results of a postdoctoral investigation. The research aims to discuss the understanding of the archival manuscripts of Fernando Pessoa as a spoil and to infer the quantitative representation of these documents, as well as to identify the practices through which these representations have been mediated in the Casa Fernando Pessoa. The documentary-historical method is adopted considering the products, the museum space, and the administrative documentation from 2006 to 2017 as the empirical basis. The following are the consequences of understanding the archive as a spoil: a mix of archives as a result of improper additions, a lack of control over the preservation of the documents’ authenticity, absence of archival representations and archival bonds, the thematization of the archive in detriment of the archival description, the disarticulation between private collections and public archives and the no-compliance of methodological standards compatible with a closed archival fond. The Casa Fernando Pessoa is a place of convergence between museums’, archives’, and libraries’ materials. The total quantitative result of the representations of the archival manuscripts of Fernando Pessoa (1888-1935) is 225 representations. The following categories of representation have been identified: fac-similar, artistic, visual, graphic, and digital. This research identified the occurrence of 22 practices distributed in these following types: historical recreation, exhibition, multimedia exhibition, course, ephemerides, webcast, and digital curation. It was possible to establish that Casa Fernando Pessoa contributes to the democratization of the manuscripts’ representations through practices of diffusion and cultural mediation with archival material.
DOI: 10.6084/m9.figshare.6967940
title: PHYSIOLOGICAL CHARACTERIZATION OF Rosellinia bunodes AND SYMPTOMATOLOGY OF Rosellinia ROOT ROT IN POPLAR SEEDLINGS

description: ABSTRACT Poplar (Populus deltoides) is a forest species that has several phytosanitary problems, such as leaf spots, rusts and root rots. Since 2010, the death of poplar trees has been observed in commercial plantations in the state of Paraná, Brazil, caused by the fungus Rosellinia bunodes. Due to the lack of information about this pathosystem, the aim of this work was to carry out the physiological characterization of R. bunodes isolates collected from P. deltoides and the symptomatological characterization of Rosellinia root rot in the same host. Experiments were conducted at Embrapa Florestas, located in Colombo (PR), Brazil. The mycelial growth of nine R. bunodes isolates was evaluated in four culture media (potato-dextrose-agar, V8-agar, carrot-agar and water-agar) and seven different incubation temperatures (8, 12, 16, 20 24, 28 and 32 °C). The symptomatological characterization of Rosellinia root rot was performed on six-month-old poplar seedlings. The most favorable conditions for mycelial growth of R. bunodes were observed in potato dextrose agar (PDA) at 24 °C. The symptoms and signs of the disease internally in the stem showed up at 7 days after inoculation (DAI); however, chlorosis and wilting were observed only at 14 DAI. Sexual and asexual reproductive structures of R. bunodes were not observed on inoculated plants.