cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22092852
title: Impact of Roux-en-Y Gastric Bypass and Vertical Gastrectomy on weight loss: a retrospective and longitudinal study in the State of Paraná, Brazil

description: ABSTRACT Aim: to compare the impact of Roux’s Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) techniques on body weight reduction over 1 and 5 years after bariatric surgery in obese patients in the state of Paraná. Methods: longitudinal and retrospective study, conducted between January 2010 and December 2013, with 737 patients of both sexes submitted to RYGB or SG and evaluated in the preoperative, 1 and 5 years after bariatric surgery (BS). Age, height, body weight, Body Mass Index (BMI), biochemical and pressure parameters were recorded. Results: of the total of patients, men represented lower frequency, were slightly older, with higher body weight, BMI and worse metabolic and pressure conditions than women in pre-BS (p&lt;0.05). Regardless of sex, RYGB and SG were effective in promoting body weight reduction and BMI in 1 and 5 years after BS; the RYGB technique had greater impact on these variables in both sexes (p&lt;0.05). The highest percentage of lost weight was observed in women who underwent the RYGB technique in the first year after BS. Five years after BS, the RYGB technique promoted a higher rate of body weight reduction in men and women compared to the SG technique (p&lt;0.05). Conclusion: regardless of sex, the RYGB technique promotes a higher degree of body weight reduction and BMI over time compared to the SG; having its biggest impacts in the 1 year after BS, especially in women.
DOI: 10.6084/m9.figshare.22092852.v1
title: Impact of Roux-en-Y Gastric Bypass and Vertical Gastrectomy on weight loss: a retrospective and longitudinal study in the State of Paraná, Brazil

description: ABSTRACT Aim: to compare the impact of Roux’s Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) techniques on body weight reduction over 1 and 5 years after bariatric surgery in obese patients in the state of Paraná. Methods: longitudinal and retrospective study, conducted between January 2010 and December 2013, with 737 patients of both sexes submitted to RYGB or SG and evaluated in the preoperative, 1 and 5 years after bariatric surgery (BS). Age, height, body weight, Body Mass Index (BMI), biochemical and pressure parameters were recorded. Results: of the total of patients, men represented lower frequency, were slightly older, with higher body weight, BMI and worse metabolic and pressure conditions than women in pre-BS (p&lt;0.05). Regardless of sex, RYGB and SG were effective in promoting body weight reduction and BMI in 1 and 5 years after BS; the RYGB technique had greater impact on these variables in both sexes (p&lt;0.05). The highest percentage of lost weight was observed in women who underwent the RYGB technique in the first year after BS. Five years after BS, the RYGB technique promoted a higher rate of body weight reduction in men and women compared to the SG technique (p&lt;0.05). Conclusion: regardless of sex, the RYGB technique promotes a higher degree of body weight reduction and BMI over time compared to the SG; having its biggest impacts in the 1 year after BS, especially in women.
DOI: 10.6084/m9.figshare.22092853.v1
title: Assessment of the regenerative potential of macro-porous chitosan-calcium simvastatin scaffolds on bone cells

description: Abstract This study evaluated the bioactive potential of a macro-porous chitosan scaffold incorporated with calcium hydroxide (CH-Ca) and functionalized with bioactive doses of simvastatin (SV) for bone tissue regeneration. Initially, the bioactive dose of SV in osteoblastic cells (SAOS-2) was determined. For the direct contact experiment, SAOS-2 cells were plated on scaffolds to assess cell viability and osteogenic differentiation. The second assay was performed at a distance using extracts from scaffolds incubated in culture medium to assess the effect of conditioned medium on viability and osteogenic differentiation. The initial screening showed that 1 μM SV presented the best biostimulating effects, and this dose was selected for incorporation into the CH-Ca and pure chitosan (CH) scaffolds. The cells remained viable throughout the direct contact experiment, with the greatest cell density in the CH-Ca and CH-Ca-SV scaffolds because of their higher porosity. The CH-Ca-SV scaffold showed the most intense bio-stimulating effect in assays in the presence and absence of osteogenic medium, leading to an increased deposition of mineralized matrix. There was an increase in the viability of cells exposed to the extracts for CH-Ca, CH-SV, and CH-Ca-SV during the one-day period. There was an increase in ALP activity in the CH-Ca and CH-Ca-SV; however, the CH-Ca-SV scaffold resulted in an intense increase in the deposition of mineralized nodules, approximately 56.4% at 7 days and 117% at 14 days, compared with CH (control). In conclusion, functionalization of the CH-Ca scaffold with SV promoted an increase in bioactivity, presenting a promising option for bone tissue regeneration.
DOI: 10.6084/m9.figshare.22092853
title: Assessment of the regenerative potential of macro-porous chitosan-calcium simvastatin scaffolds on bone cells

description: Abstract This study evaluated the bioactive potential of a macro-porous chitosan scaffold incorporated with calcium hydroxide (CH-Ca) and functionalized with bioactive doses of simvastatin (SV) for bone tissue regeneration. Initially, the bioactive dose of SV in osteoblastic cells (SAOS-2) was determined. For the direct contact experiment, SAOS-2 cells were plated on scaffolds to assess cell viability and osteogenic differentiation. The second assay was performed at a distance using extracts from scaffolds incubated in culture medium to assess the effect of conditioned medium on viability and osteogenic differentiation. The initial screening showed that 1 μM SV presented the best biostimulating effects, and this dose was selected for incorporation into the CH-Ca and pure chitosan (CH) scaffolds. The cells remained viable throughout the direct contact experiment, with the greatest cell density in the CH-Ca and CH-Ca-SV scaffolds because of their higher porosity. The CH-Ca-SV scaffold showed the most intense bio-stimulating effect in assays in the presence and absence of osteogenic medium, leading to an increased deposition of mineralized matrix. There was an increase in the viability of cells exposed to the extracts for CH-Ca, CH-SV, and CH-Ca-SV during the one-day period. There was an increase in ALP activity in the CH-Ca and CH-Ca-SV; however, the CH-Ca-SV scaffold resulted in an intense increase in the deposition of mineralized nodules, approximately 56.4% at 7 days and 117% at 14 days, compared with CH (control). In conclusion, functionalization of the CH-Ca scaffold with SV promoted an increase in bioactivity, presenting a promising option for bone tissue regeneration.
DOI: 10.6084/m9.figshare.22092856
title: Adolescent health in the Brazilian federal school system: a metasynthesis

description: ABSTRACT The institutions of the federal educational network have their own health team and, therefore, have the possibility of developing multiple strategies for the implementation of School Health Program actions. This study aimed to systematize and synthesize the scientific production developed by workers from the federal educational network on adolescent health in the school environment. This is a qualitative meta-synthesis carried out from searches on the Virtual Health Library, Brazilian Digital Library of Theses and Dissertations, and Google. Content analysis was used for data analysis. The sample consisted of 15 publications and 4 thematic units emerged: pedagogical integration of health education in federal institutes; conception of adolescence and adolescent health in the school environment in federal institutes; perspectives of health work in federal institutes with adolescents; and facilities and difficulties in the development of adolescent health in the school environment in federal institutes. It was found that the scientific production on the subject is still incipient. Even in federal institutes, it is necessary to advance in the methodology of activities and in the topics of health education developed. It is necessary to stimulate youth protagonism, transcending the hygienist and fragmented aspects of school health.
DOI: 10.6084/m9.figshare.22092856.v1
title: Adolescent health in the Brazilian federal school system: a metasynthesis

description: ABSTRACT The institutions of the federal educational network have their own health team and, therefore, have the possibility of developing multiple strategies for the implementation of School Health Program actions. This study aimed to systematize and synthesize the scientific production developed by workers from the federal educational network on adolescent health in the school environment. This is a qualitative meta-synthesis carried out from searches on the Virtual Health Library, Brazilian Digital Library of Theses and Dissertations, and Google. Content analysis was used for data analysis. The sample consisted of 15 publications and 4 thematic units emerged: pedagogical integration of health education in federal institutes; conception of adolescence and adolescent health in the school environment in federal institutes; perspectives of health work in federal institutes with adolescents; and facilities and difficulties in the development of adolescent health in the school environment in federal institutes. It was found that the scientific production on the subject is still incipient. Even in federal institutes, it is necessary to advance in the methodology of activities and in the topics of health education developed. It is necessary to stimulate youth protagonism, transcending the hygienist and fragmented aspects of school health.
DOI: 10.6084/m9.figshare.22092859
title: Curiosity Unlocked the Cat: The Relationship between Curiosity at Work and Worker Creativity

description: ABSTRACT Worker creativity can be considered a determining factor in the process of idea generation and innovation within a company. This behavior is determined by both worker characteristics and perceived stimuli. Therefore, in the present study, we analyzed how the worker’s creativity is influenced by his or her curiosity and ability to associate ideas. We also analyzed how the relationship between curiosity and creativity is influenced by risk propensity and the organizational support perceived by the worker. The results achieved indicate that curiosity at work has a direct and indirect effect on worker creativity. The indirect effect observed depends on the association of ideas, which tend to increase the creativity of the worker. It was also found that risk propensity and perceived organizational support for creativity did not influence the indirect relationship between curiosity and creativity. These results highlight the importance of instigating worker curiosity to induce more creative and innovative behavior.
DOI: 10.6084/m9.figshare.22092859.v1
title: Curiosity Unlocked the Cat: The Relationship between Curiosity at Work and Worker Creativity

description: ABSTRACT Worker creativity can be considered a determining factor in the process of idea generation and innovation within a company. This behavior is determined by both worker characteristics and perceived stimuli. Therefore, in the present study, we analyzed how the worker’s creativity is influenced by his or her curiosity and ability to associate ideas. We also analyzed how the relationship between curiosity and creativity is influenced by risk propensity and the organizational support perceived by the worker. The results achieved indicate that curiosity at work has a direct and indirect effect on worker creativity. The indirect effect observed depends on the association of ideas, which tend to increase the creativity of the worker. It was also found that risk propensity and perceived organizational support for creativity did not influence the indirect relationship between curiosity and creativity. These results highlight the importance of instigating worker curiosity to induce more creative and innovative behavior.
DOI: 10.6084/m9.figshare.22092861
title: School Health Program: intervention project against dengue in Matinhos, State of Paraná, Brazil

description: ABSTRACT The School Health Program (PSE) aims to promote health actions in schools through pedagogical tools developed between health and education. A study was carried out in the city of Matinhos, State of Paraná, Brazil, by the PSE within the scope of the Luiz Carlos dos Santos municipal school including 60 students from the 5th grades, from March to August 2019. Characteristics of participatory action-research and problematization methodology were used, being a type of social and qualitative study. For data collection, the method of Charles de Maguerez Arch was used. As research result, a pedagogical tool was developed at school and in the community’, the intervention project ‘School, health, environment, and community mobilized against the Aedes aegypti’. The study proved that the application of existing public policies such as the PSE, through intersectoriality, environmental health education, and mechanical vector control actions, without applicability of poison, are appropriate actions for the disease prevention, such as the elimination of vector breeding sites; thus, making effective the use of environmental health education in schools as a health promotion strategy.
DOI: 10.6084/m9.figshare.22092861.v1
title: School Health Program: intervention project against dengue in Matinhos, State of Paraná, Brazil

description: ABSTRACT The School Health Program (PSE) aims to promote health actions in schools through pedagogical tools developed between health and education. A study was carried out in the city of Matinhos, State of Paraná, Brazil, by the PSE within the scope of the Luiz Carlos dos Santos municipal school including 60 students from the 5th grades, from March to August 2019. Characteristics of participatory action-research and problematization methodology were used, being a type of social and qualitative study. For data collection, the method of Charles de Maguerez Arch was used. As research result, a pedagogical tool was developed at school and in the community’, the intervention project ‘School, health, environment, and community mobilized against the Aedes aegypti’. The study proved that the application of existing public policies such as the PSE, through intersectoriality, environmental health education, and mechanical vector control actions, without applicability of poison, are appropriate actions for the disease prevention, such as the elimination of vector breeding sites; thus, making effective the use of environmental health education in schools as a health promotion strategy.
DOI: 10.6084/m9.figshare.22092864
title: Laparoscopic adrenalectomy: comparison between pneumoperitoneum and the use of a laparoscopic lift device in dog cadavers

description: ABSTRACT: This study evaluated the feasibility of abdominal liftfor laparoscopic adrenalectomy and compared it with the conventional laparoscopic technique using pneumoperitoneum with medicinal CO2 in dog cadavers. The total surgical time (TST), adrenalectomy time (AT), and gland integrity after removal were evaluated. Thirty-eight adrenalectomies were performed in 19 cadavers. Regardless of the antimere, the TST was significantly lower in the CO2 procedures than in the lift laparoscopy procedures (P=0.001). When comparing the techniques between antimeres, the TST was significantly higher on the left side with lift laparoscopy than with CO2 (P=0.015) and similar between the techniques on the right side of the animals (P=0.086). In the comparison of AT, regardless of the execution side, no differences were observed between the techniques (P=0.05). The same was observed when AT was evaluated separately using antimeres (P=0.902). Of the 38 adrenals evaluated, 92.1% were removed in a single block, and 32.29% had a superficial lesion in the capsule. There was no difference between the groups in the removal capacity in a single block (P=0.340) and capsule integrity (P=0.287). Abdominal lift for laparoscopic adrenalectomy is a feasible technique in dog cadavers; however, it requires a longer surgical time than the conventional technique. The traction force used to elevate the abdominal wall must be evaluated.
DOI: 10.6084/m9.figshare.22092864.v1
title: Laparoscopic adrenalectomy: comparison between pneumoperitoneum and the use of a laparoscopic lift device in dog cadavers

description: ABSTRACT: This study evaluated the feasibility of abdominal liftfor laparoscopic adrenalectomy and compared it with the conventional laparoscopic technique using pneumoperitoneum with medicinal CO2 in dog cadavers. The total surgical time (TST), adrenalectomy time (AT), and gland integrity after removal were evaluated. Thirty-eight adrenalectomies were performed in 19 cadavers. Regardless of the antimere, the TST was significantly lower in the CO2 procedures than in the lift laparoscopy procedures (P=0.001). When comparing the techniques between antimeres, the TST was significantly higher on the left side with lift laparoscopy than with CO2 (P=0.015) and similar between the techniques on the right side of the animals (P=0.086). In the comparison of AT, regardless of the execution side, no differences were observed between the techniques (P=0.05). The same was observed when AT was evaluated separately using antimeres (P=0.902). Of the 38 adrenals evaluated, 92.1% were removed in a single block, and 32.29% had a superficial lesion in the capsule. There was no difference between the groups in the removal capacity in a single block (P=0.340) and capsule integrity (P=0.287). Abdominal lift for laparoscopic adrenalectomy is a feasible technique in dog cadavers; however, it requires a longer surgical time than the conventional technique. The traction force used to elevate the abdominal wall must be evaluated.
DOI: 10.6084/m9.figshare.22092870
title: Film, music and sensory experience: questions concerning a project to film participatory musical performances

description: Abstract This text sets out to discuss questions arising from the work of filming Brazilian popular festivals, celebrations and rituals in which music-making involves a process of collective musical production, practices linked to what Turino (2008) has called ‘participatory music.’ By making music together, the participants take part in intense non-verbal social interactions that very often reach a collective climax or trace, an experience difficult to translate into words. How can film express and communicate this type of musical experience involving all the senses? Setting out from technical guidelines developed in a project to film participative musical performances for a documentary series, Taquaras, Tambores e Violas, the text aims to reflect on the potential of the audiovisual medium as an experiential mode that both apprehends the musical context and enables the spectator to access and discover the participatory performances depicted through the evoked experience and senses.
DOI: 10.6084/m9.figshare.22092870.v1
title: Film, music and sensory experience: questions concerning a project to film participatory musical performances

description: Abstract This text sets out to discuss questions arising from the work of filming Brazilian popular festivals, celebrations and rituals in which music-making involves a process of collective musical production, practices linked to what Turino (2008) has called ‘participatory music.’ By making music together, the participants take part in intense non-verbal social interactions that very often reach a collective climax or trace, an experience difficult to translate into words. How can film express and communicate this type of musical experience involving all the senses? Setting out from technical guidelines developed in a project to film participative musical performances for a documentary series, Taquaras, Tambores e Violas, the text aims to reflect on the potential of the audiovisual medium as an experiential mode that both apprehends the musical context and enables the spectator to access and discover the participatory performances depicted through the evoked experience and senses.
DOI: 10.6084/m9.figshare.22092874
title: IL17A and IL17RA gene polymorphisms in Fanconi anemia

description: Abstract Fanconi anemia is a rare autosomal recessive disease. In this disease, cytokine pathways can induce the bone marrow failure that is observed in individuals with Fanconi anemia. Interleukin IL-17 exhibits a protective effect in organisms because it induces neutrophil recruitment and shows a pathological role in several models of autoimmune diseases, periodontal disease, cancer, allograft rejection, and graft versus host disease. Polymorphisms in the IL17A and IL17RA genes were evaluated from DNA in saliva, comparing individuals with or without Fanconi anemia, using models of genotypic transmission (additive, dominant, and recessive). Polymorphisms in the IL17A and IL17RA genes (rs2241044 [C allele], rs879577 [C allele], rs9606615 [T allele], and rs2241043 [C allele]) were risk factors for developing Fanconi anemia. We also performed an analysis of gene markers with clinical variables in the Fanconi group. Polymorphisms in the IL17A gene (rs3819025 [A allele] and rs2275913 [G allele], respectively) were associated with an age of less than 20 years (p = 0.026; RP 0.65) and the female sex (p = 0.043; RP 0.88). The IL17RA gene was also associated with age and the presence of leukoplakia (a potentially malignant oral disorder). An age of less than 20 years was associated with rs917864 (T allele; p = 0.036; RP 0.67). The presence of leukoplakia was associated with rs17606615 (T allele; p = 0.042; RP 0.47). To our knowledge, this is the first study that associates IL17A and IL17RA gene polymorphisms with Fanconi anemia and examines rs2241044 polymorphisms in scientific literature thus far.
DOI: 10.6084/m9.figshare.22092874.v1
title: IL17A and IL17RA gene polymorphisms in Fanconi anemia

description: Abstract Fanconi anemia is a rare autosomal recessive disease. In this disease, cytokine pathways can induce the bone marrow failure that is observed in individuals with Fanconi anemia. Interleukin IL-17 exhibits a protective effect in organisms because it induces neutrophil recruitment and shows a pathological role in several models of autoimmune diseases, periodontal disease, cancer, allograft rejection, and graft versus host disease. Polymorphisms in the IL17A and IL17RA genes were evaluated from DNA in saliva, comparing individuals with or without Fanconi anemia, using models of genotypic transmission (additive, dominant, and recessive). Polymorphisms in the IL17A and IL17RA genes (rs2241044 [C allele], rs879577 [C allele], rs9606615 [T allele], and rs2241043 [C allele]) were risk factors for developing Fanconi anemia. We also performed an analysis of gene markers with clinical variables in the Fanconi group. Polymorphisms in the IL17A gene (rs3819025 [A allele] and rs2275913 [G allele], respectively) were associated with an age of less than 20 years (p = 0.026; RP 0.65) and the female sex (p = 0.043; RP 0.88). The IL17RA gene was also associated with age and the presence of leukoplakia (a potentially malignant oral disorder). An age of less than 20 years was associated with rs917864 (T allele; p = 0.036; RP 0.67). The presence of leukoplakia was associated with rs17606615 (T allele; p = 0.042; RP 0.47). To our knowledge, this is the first study that associates IL17A and IL17RA gene polymorphisms with Fanconi anemia and examines rs2241044 polymorphisms in scientific literature thus far.