DOI: 10.25550/1-x5hr
title: Gene summary for Fgfr2

description: ### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=FGFR2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=FGFR2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=FGFR2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=FGFR2) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Fgfr2_posterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Fgfr2_posterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Fgfr2_posterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Fgfr2_posterior_E15.5.jpg) | ### Gene expression in the secondary palate _Fgfr2_ is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_coronal_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_coronal_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_coronal_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_coronal_E15.5_0.jpg){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_oral_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_oral_E13.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_oral_E14.5_0.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Fgfr2_oral_E15.5_0.jpg){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/6DC577.gif) Nasal mesenchyme ![Image](/hatrac/facebase/genesummaries/A5C2EA.gif) Posterior mesenchyme ![Image](/hatrac/facebase/genesummaries/legend_blue_line.png) All epithelium #### Sources: - Snyder-Warwick et al. (2010) [Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.](http://www.ncbi.nlm.nih.gov/pubmed/20133659) PNAS 107(6): 2515-20. - Porntaveetus et al. (2010) [Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.](http://www.ncbi.nlm.nih.gov/pubmed/20348033) Gene Expr. Patterns 10(4-5): 193-8. ### Gene expression in the mandibular and maxillary arches _Fgfr2_ is expressed in the epithelium and mesenchyme of the maxillary and mandibular arches at E10.5. A E12.5, it is expressed in the oral epithelium and the Meckel’s cartilage. At E14.5, Fgfr2 is expressed in the oral epithelium, dental epithelium, Meckel’s cartilage, and differentiated osteoblasts in maxilla and mandible. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/fgfr2-10.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/fgfr2-12.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/fgfr2-14.5.jpg){width=280 height=214} | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Mandibular and maxillary | ![Image](/hatrac/facebase/genesummaries/755f8e.gif) Meckel’s cartilage | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Differentiated osteblasts | | mesenchyme | ![Image](/hatrac/facebase/genesummaries/48a3ea.gif) Oral epithelium | in mandible and maxilla | | ![Image](/hatrac/facebase/genesummaries/48a3ea.gif) Mandibular and maxillary | | ![Image](/hatrac/facebase/genesummaries/755f8e.gif) Meckel’s cartilage | | epithelium | | ![Image](/hatrac/facebase/genesummaries/48a3ea.gif) Oral epithelium | #### Sources: - Finch PW et al., Dev Dyn. 1995 Jun;203(2):223-40. - Orr-Urtreger A et al., Development. 1991 Dec;113(4):1419-34. - Bachler M et al., Mech Dev., 2001 Feb;100(2):313-6. - Snyder-Warwick AK et al., Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2515-20. - Visel A et al., Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6. - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/). ### External Links - [Fgfr2 fibroblast growth factor receptor 2 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/14183) - [Fgfr2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/2263) - [Fgfr2 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=FGFR2&search=FGFR2) - [Fgfr2 Wikipedia](http://en.wikipedia.org/wiki/FGFR2)