cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5125567.v1
title: Supplementary Material for: Clinical Profile and Prognostic Significance of Atrial Fibrillation in Hypertrophic Cardiomyopathy

description: <b><i>Objectives:</i></b> The clinical outcomes of hypertrophic cardiomyopathy (HCM) are largely unpredictable. This study aimed to investigate the relationship between atrial fibrillation (AF) and its prognostic implications in Chinese patients with HCM. <b><i>Methods:</i></b> From 1999 to 2011, 654 unrelated HCM patients were consecutively recruited at Fuwai Hospital. Medical history, including electrocardiographic and echocardiographic data, was analyzed. <b><i>Results:</i></b> AF was documented in 158 patients (24%). During follow-up of 4.2 ± 2.8 years, Kaplan-Meier analysis revealed that the presence of AF was associated with an increased risk for all-cause death (p = 0.001), cardiovascular death (p &lt; 0.001), severe heart failure (p &lt; 0.001) and ischemic stroke (p &lt; 0.001). Multivariate analysis identified AF as an independent predictor of stroke-related death (HR 6.71, 95% CI 1.23-38.58, p = 0.03), advanced heart failure (HR 1.83, 95% CI 1.04-3.22, p = 0.04) and ischemic stroke (HR 9.98, 95% CI 4.06-24.53, p &lt; 0.001). Furthermore, enlarged left atrial diameter was positively related to all-cause death (HR 1.09, 95% CI 1.05-1.13, p &lt; 0.001), cardiovascular death (HR 1.08, 95% CI 1.04-1.20, p &lt; 0.001) and development of advanced heart failure (HR 1.05, 95% CI 1.01-1.10, p = 0.01). <b><i>Conclusions:</i></b> AF predicts poor outcomes for patients with HCM. Left atrial dilation is also related to an adverse prognosis and provides additional prognostic information.
DOI: 10.6084/m9.figshare.5125555
title: Supplementary Material for: Assessment of Adjuvant Trastuzumab-Associated Cardiac Toxicity in Korean Patients with Breast Cancer: A Single-Center Analysis

description: <b><i>Background</i></b>: We performed this analysis to investigate the clinical presentation of trastuzumab-associated cardiac toxicity in Korean women. <b><i>Method:</i></b> 124 patients treated in a single institute from January 2006 to November 2011 with adjuvant trastuzumab therapy following primary surgery were identified from a database. We evaluated the cumulative incidence of cardiac toxicity, associated risk factors, and changes in cardiac function during trastuzumab treatment. <b><i>Results:</i></b> The median age of patients was 50 years (range 27-73). After 12 months of follow-up, the cumulative incidence of cardiac toxicity was 12.1% (grade I: 8.1%, grade II: 0.8%, grade III: 3.2%). In total, 4% of patients discontinued treatment due to cardiac dysfunction. The left ventricular ejection fraction (LVEF) recovered in all patients who discontinued or delayed treatment due to cardiac dysfunction following treatment discontinuation. The degree of the decrease in LVEF was large at 6 months after the initiation of treatment. A lower LVEF at baseline (&lt;65%) was associated with cardiac toxicity. <b><i>Conclusions:</i></b> The low incidence of cardiac toxicity and the reversibility of cardiac dysfunction may validate the safety of trastuzumab treatment in Korean women with an acceptable baseline LVEF.
DOI: 10.6084/m9.figshare.5125549
title: Supplementary Material for: CBASP@home: Ein internetbasiertes Situationsanalysen-Training zur Stabilisierung des Therapieerfolgs nach stationärer Therapie für chronisch depressive Patienten

description: <b><i>Hintergrund: </i></b>Aufbauend auf einer ambulanten CBASP-Behandlung wurde ein stationäres multidisziplinäres Konzept zur Behandlung chronischer Depression entwickelt. Eine Pilotstudie zeigte positive Ergebnisse hinsichtlich der Wirkung dieses Konzepts, jedoch berichteten einige Patienten, dass die 12-wöchige Therapie zu kurz und die Zeit unmittelbar nach Entlassung schwierig sei. Daher wurde CBASP@home als ein internetbasiertes Situationsanalysen (SA)-Training zur Stabilisierung des erzielten Behandlungserfolgs konzipiert. CBASP@home ist eine 3-monatige Step-down-Onlineintervention. Die Patienten werden dabei unterstützt, die erlernten SA zu Hause fortzuführen und in den Alltag zu transferieren. An insgesamt 9 Terminen füllten die Patienten das SA-Formular über einen Sicherheitsserver aus und erhielten von ihrem stationären Psychotherapeuten zeitnah Rückmeldung. <b><i>Fallbericht: </i></b>In der vorliegenden Phase-I-Studie wurde die Akzeptanz und Durchführbarkeit von CBASP@home an 2 Einzelfällen untersucht. CBASP@home wurde von beiden Patienten sehr gut angenommen und als sinnvolle Unterstützung bewertet. Zudem konnte bei beiden Patienten eine zunehmende Leistungssteigerung in der SA-Durchführung bei gleichzeitig rückläufiger depressiver Symptomatik bis zur Remission beobachtet werden. <b><i>Schlussfolgerungen: </i></b>Die beiden Einzelfallauswertungen liefern Hinweise, dass CBASP@home Transferprozesse vom stationären Setting in den Alltag erleichtern, Behandlungserfolge beibehalten bzw. Rückfällen vorbeugen kann. Wenn sich diese positiven Erfahrungen in zukünftigen Studien bestätigen sollten, kann CBASP@home wesentlich zur Verbesserung der langfristigen Versorgung chronisch depressiver Patienten beitragen.
DOI: 10.6084/m9.figshare.5125546
title: Supplementary Material for: Intramural Hematoma Detection by Susceptibility-Weighted Imaging in Intracranial Vertebral Artery Dissection

description: <b><i>Background:</i></b> The radiologic diagnosis of vertebral artery dissection (VAD) depends on characteristic intraluminal findings on angiography and intramural hematoma or a double-lumen sign on high-resolution vessel wall imaging. We aimed to evaluate the accuracy of intramural hematoma sign on susceptibility-weighted imaging (SWI) in VAD. <b><i>Methods:</i></b> We retrospectively analyzed SWI, phase map images and brain computed tomography (CT) of the consecutive patients who suffered an ischemic stroke in the vertebral artery territory from August 2010 to July 2012. We divided the patients into 2 groups: the VAD group and the nondissection group. VAD was diagnosed by conventional catheter angiographic findings (aneurysmal dilatation, pearl-and-string or tapered steno-occlusion) and pathognomonic findings such as intramural hematoma or a double-lumen sign on the source images of TOF-MRA, high-resolution T<sub>1</sub>-weighted MRI or high-resolution T<sub>2</sub>-weighted MRI. Intramural hematoma sign was considered positive if the patient had an eccentric or concentric hypointense signal lesion in the vertebral artery on SWI, a corresponding hyperintense signal on phase map and no evidence of calcification on the brain CT, suggesting blood products other than calcification. Two experienced neuroradiologists blinded to clinical information and angiographic findings were asked to judge for the presence of intramural hematoma sign on SWI. The accuracy of intramural hematoma sign on SWI was evaluated. Phase value, demographic and clinical data were compared between the VAD and the nondissection groups. <b><i>Results:</i></b> Thirty-nine patients were included: 10 in the VAD group and 29 in the non-dissection group. Among the VAD group cases, intramural hematoma sign on SWI was positive in 9 of the 10 VAD cases and in 1 out of the 29 cases in the nondissection group. The intramural hematoma sign on SWI was significantly associated with VAD (p &lt; 0.001), and showed sensitivity of 90% and specificity of 96.6%. Mean phase values of intramural hematomas (n = 9) were all positive and those of calcified lesions (n = 13) were all negative (0.45 radian vs. -0.42 radian, p &lt; 0.001). <b><i>Conclusions:</i></b> The intramural hematoma sign on SWI was significantly associated with VAD and the phase map values were higher in intramural hematomas when compared with atherosclerotic calcifications.
DOI: 10.6084/m9.figshare.5125552
title: Supplementary Material for: Twenty Years of Physical Mapping of Major Ribosomal RNA Genes across the Teleosts: A Review of Research

description: Molecular cytogenetic data on the number and position of 45S ribosomal RNA genes (rDNA; located in nucleolus organizing regions, NORs) detected by FISH in 330 species of 77 families and 22 orders of bony fishes (Teleostei) and, additionally, 11 species of basal ray-finned fishes are compiled and analyzed. The portion of species with single rDNA sites in the sample amounts to 72%. The percentage of species with multiple NORs decreases with increasing numbers of rDNA loci per genome, i.e. scarcely 3% of species carry 4 or more rDNA-bearing chromosome pairs. 43% of all rDNA sites analyzed occur terminally on the short arms of chromosomes or constitute them. In general, terminal rDNA sites account for 87% of all examined cases. Interspecific variation in the location of single rDNA sites among related taxa, polymorphisms of multiple NORs in some groups of teleosts and analytical outcomes on the subject are reviewed.
DOI: 10.6084/m9.figshare.5125555.v1
title: Supplementary Material for: Assessment of Adjuvant Trastuzumab-Associated Cardiac Toxicity in Korean Patients with Breast Cancer: A Single-Center Analysis

description: <b><i>Background</i></b>: We performed this analysis to investigate the clinical presentation of trastuzumab-associated cardiac toxicity in Korean women. <b><i>Method:</i></b> 124 patients treated in a single institute from January 2006 to November 2011 with adjuvant trastuzumab therapy following primary surgery were identified from a database. We evaluated the cumulative incidence of cardiac toxicity, associated risk factors, and changes in cardiac function during trastuzumab treatment. <b><i>Results:</i></b> The median age of patients was 50 years (range 27-73). After 12 months of follow-up, the cumulative incidence of cardiac toxicity was 12.1% (grade I: 8.1%, grade II: 0.8%, grade III: 3.2%). In total, 4% of patients discontinued treatment due to cardiac dysfunction. The left ventricular ejection fraction (LVEF) recovered in all patients who discontinued or delayed treatment due to cardiac dysfunction following treatment discontinuation. The degree of the decrease in LVEF was large at 6 months after the initiation of treatment. A lower LVEF at baseline (&lt;65%) was associated with cardiac toxicity. <b><i>Conclusions:</i></b> The low incidence of cardiac toxicity and the reversibility of cardiac dysfunction may validate the safety of trastuzumab treatment in Korean women with an acceptable baseline LVEF.
DOI: 10.6084/m9.figshare.5125540
title: Supplementary Material for: Kidney Attack: Overdiagnosis of Acute Kidney Injury or Comprehensive Definition of Acute Kidney Syndromes?

description: Medicine
DOI: 10.6084/m9.figshare.5125543
title: Supplementary Material for: Visual Contrast Sensitivity Deficits in ‘Normal' Visual Field of Patients with Homonymous Visual Field Defects due to Stroke: A Pilot Study

description: <b><i>Background:</i></b> Homonymous visual field defects (VFD) are common following stroke, and often recover, partially or fully, by unknown mechanisms. In clinical practice, visual field recovered on perimetry is often considered perceptually normal. However, studies have shown contrast sensitivity (CS) deficits in patients with stroke and homonymous VFD. This study investigated the origin of visual CS loss in patients with VFD due to stroke. We hypothesised that CS deficits would be found in visual field areas appearing normal on perimetry, in patients with ischaemic stroke affecting the retrochiasmal visual system, and that the spatiotemporal properties of this CS loss would be consistent with those of ‘blindsight', perhaps suggesting similar underlying mechanisms. <b><i>Methods:</i></b> CS measurements were made in 20 healthy participants, and in 7 patients with stroke causing homonymous VFD sparing foveal vision, measured using Humphrey static perimetry (SITA-Fast 24-2 procedure). Importantly, patients with concomitant visuospatial neglect were excluded. CS measurements were made using a modification of the method of increasing contrast, corrected for reaction time. Three spatial stimuli were used, at several spatial frequencies: (1) large sinusoidal gratings; (2) foveal Gabor patches; and (3) Gabor patches presenting in the putatively recovered visual field, near VFD. Stimuli with different temporal profiles were used to selectively stimulate transient and sustained visual channels, to provide insight into mechanisms of visual loss and/or recovery. Analysis of variance (ANOVA) was used in the analysis of the measurements, allowing for correction for age and stimulus eccentricity. <b><i>Results:</i></b> ANOVA for sustained grating stimuli showed orientation-selective (horizontal) CS loss (p = 0.025); no such loss was apparent in the central visual field (foveal Gabor stimuli). Localised CS close to VFD was reduced in stroke-affected hemifields compared with unaffected hemifields (p ≤ 0.005), though these areas appeared normal on perimetry. In these areas, CS was relatively preserved for transient compared with sustained stimuli (Wilcoxon signed rank tests). <b><i>Conclusions:</i></b> The finding of specific CS deficits in the normal-appearing visual field of patients with homonymous VFD due to stroke suggests that static perimetry provides an inadequate assessment of visual function in these patients, with clear implications for testing of vision in clinical practice. The results are consistent with relative sparing of the transient/magnocellular visual channel. These findings demand further investigation. If confirmed in larger, longitudinal studies, this will have important implications for the mechanisms of recovery, and may provide a target for visual rehabilitation - for example, using repeated detection practice (‘perceptual learning').
DOI: 10.6084/m9.figshare.5125543.v1
title: Supplementary Material for: Visual Contrast Sensitivity Deficits in ‘Normal' Visual Field of Patients with Homonymous Visual Field Defects due to Stroke: A Pilot Study

description: <b><i>Background:</i></b> Homonymous visual field defects (VFD) are common following stroke, and often recover, partially or fully, by unknown mechanisms. In clinical practice, visual field recovered on perimetry is often considered perceptually normal. However, studies have shown contrast sensitivity (CS) deficits in patients with stroke and homonymous VFD. This study investigated the origin of visual CS loss in patients with VFD due to stroke. We hypothesised that CS deficits would be found in visual field areas appearing normal on perimetry, in patients with ischaemic stroke affecting the retrochiasmal visual system, and that the spatiotemporal properties of this CS loss would be consistent with those of ‘blindsight', perhaps suggesting similar underlying mechanisms. <b><i>Methods:</i></b> CS measurements were made in 20 healthy participants, and in 7 patients with stroke causing homonymous VFD sparing foveal vision, measured using Humphrey static perimetry (SITA-Fast 24-2 procedure). Importantly, patients with concomitant visuospatial neglect were excluded. CS measurements were made using a modification of the method of increasing contrast, corrected for reaction time. Three spatial stimuli were used, at several spatial frequencies: (1) large sinusoidal gratings; (2) foveal Gabor patches; and (3) Gabor patches presenting in the putatively recovered visual field, near VFD. Stimuli with different temporal profiles were used to selectively stimulate transient and sustained visual channels, to provide insight into mechanisms of visual loss and/or recovery. Analysis of variance (ANOVA) was used in the analysis of the measurements, allowing for correction for age and stimulus eccentricity. <b><i>Results:</i></b> ANOVA for sustained grating stimuli showed orientation-selective (horizontal) CS loss (p = 0.025); no such loss was apparent in the central visual field (foveal Gabor stimuli). Localised CS close to VFD was reduced in stroke-affected hemifields compared with unaffected hemifields (p ≤ 0.005), though these areas appeared normal on perimetry. In these areas, CS was relatively preserved for transient compared with sustained stimuli (Wilcoxon signed rank tests). <b><i>Conclusions:</i></b> The finding of specific CS deficits in the normal-appearing visual field of patients with homonymous VFD due to stroke suggests that static perimetry provides an inadequate assessment of visual function in these patients, with clear implications for testing of vision in clinical practice. The results are consistent with relative sparing of the transient/magnocellular visual channel. These findings demand further investigation. If confirmed in larger, longitudinal studies, this will have important implications for the mechanisms of recovery, and may provide a target for visual rehabilitation - for example, using repeated detection practice (‘perceptual learning').
DOI: 10.6084/m9.figshare.5125552.v1
title: Supplementary Material for: Twenty Years of Physical Mapping of Major Ribosomal RNA Genes across the Teleosts: A Review of Research

description: Molecular cytogenetic data on the number and position of 45S ribosomal RNA genes (rDNA; located in nucleolus organizing regions, NORs) detected by FISH in 330 species of 77 families and 22 orders of bony fishes (Teleostei) and, additionally, 11 species of basal ray-finned fishes are compiled and analyzed. The portion of species with single rDNA sites in the sample amounts to 72%. The percentage of species with multiple NORs decreases with increasing numbers of rDNA loci per genome, i.e. scarcely 3% of species carry 4 or more rDNA-bearing chromosome pairs. 43% of all rDNA sites analyzed occur terminally on the short arms of chromosomes or constitute them. In general, terminal rDNA sites account for 87% of all examined cases. Interspecific variation in the location of single rDNA sites among related taxa, polymorphisms of multiple NORs in some groups of teleosts and analytical outcomes on the subject are reviewed.
DOI: 10.6084/m9.figshare.5125537
title: Supplementary Material for: A Randomized Controlled Trial of Individual Cognitive Therapy, Group Cognitive Behaviour Therapy and Attentional Placebo for Adolescent Social Phobia

description: <b><i>Background:</i></b> Very few studies have investigated the effects of individual disorder-specific treatment of social phobia (SP) in adolescents. The objective of this study was to compare the effects of individual cognitive therapy for SP, group cognitive behavioural therapy (CBTG) and attentional placebo (AP) among adolescents with a primary diagnosis of SP. <b><i>Methods:</i></b> A randomized controlled design was used, and a total of 279 adolescents were assessed. Fifty-seven adolescents, between 13 and 16 years old, were allocated to individual cognitive therapy, CBTG or AP. The participants were assessed before treatment, at the end of treatment and at a 12-month follow-up using both self-report and a semi-structured interview. <b><i>Results:</i></b> The individual cognitive therapy showed significant reductions in symptoms, impairment and diagnostic criteria both at the end of treatment and at the 12-month follow-up. Compared with CBTG and AP, the individual cognitive therapy group demonstrated significantly greater effects on both symptom reduction and impairment. There were no significant differences between CBTG and AP. <b><i>Conclusions:</i></b> In a direct comparison between the most commonly used treatments for adolescent SP, we found that individual therapy was the most effective, yielding better effects than both CBTG and AP.
DOI: 10.6084/m9.figshare.5125531
title: Supplementary Material for: Divergence of Repetitive DNA Sequences in the Heterochromatin of Medaka Fishes: Molecular Cytogenetic Characterization of Constitutive Heterochromatin in Two Medaka Species: <b><i>Oryzias hubbsi</i></b> and <b><i>O. celebensis</i></b> (Adrianichthyidae, Beloniformes)

description: The large biarmed chromosomes of <i>Oryzias celebensis</i> [2n = 36, fundamental arm number (FN) = 48] are considered to have resulted from fusions of acrocentric chromosomes in the ancestral karyotype of <i>Oryzias</i>, which is retained in <i>O. hubbsi</i> (2n<i> = </i>48, FN = 48). To understand the molecular evolution of heterochromatin associated with karyotype reorganization in medaka fishes, we cloned 3 and 6 novel families of heterochromatin-related repetitive DNA sequences from <i>O</i>.<i> hubbsi</i> and <i>O. celebensis</i>, respectively, and characterized them using molecular cytogenetics. Two AT-rich repetitive sequences isolated from the genomic DNA of <i>O. hubbsi</i>, a 164-bp satellite DNA (OHU-<i>Rsa</i>I-Scen) and a 177-bp telomere-specific repeat (OHU-<i>Rsa</i>I-Stelo), were shown to be major components of the constitutive heterochromatin of centromeres and telomeres, respectively. A GC-rich 326-bp sequence, named OHU-<i>Alu</i>I-M1, was colocalized with the 18S-28S ribosomal RNA gene cluster to a single autosomal pair of chromosomes and the W chromosome. In <i>O. celebensis</i>, 2 major satellite DNA sequences (the AT-rich 157-bp OCE-<i>Alu</i>I-Scen sequence and the 186-bp OCE-<i>Hin</i>fI-Scen sequence) were identified in the centromeric regions of almost all chromosomes. The 197-bp OCE-<i>Hin</i>fI-S6 sequence was located in the centromeric and distal and/or interstitial heterochromatin of almost all chromosomes, and the 191-bp OCE-<i>Hin</i>fI-S8 sequence was located in 6 pairs of chromosomes. Constitutive heterochromatin on the short arm of large submetacentric chromosome 5 was composed of at least 3 different repetitive sequences: the 171-bp OCE-<i>Alu</i>I-S18 sequence, the 197-bp OCE-<i>Hin</i>fI-S6 sequence and the 172-bp OCE-<i>Hin</i>fI-S11 sequence. All families of repeated sequences showed no nucleotide sequence similarity with each other and high species-specificity among 7 different species. These results suggest that the heterochromatin of <i>O</i>. <i>hubbsi</i> and <i>O</i>. <i>celebensis </i>consists of various types of repetitive sequence and that the sequences evolved independently and were then amplified site-specifically in each lineage after karyotype reorganization occurred in the ancestral karyotype.
DOI: 10.6084/m9.figshare.5125534
title: Supplementary Material for: Meta-Analysis of the Association between the <b><i>IL-12B</i></b> +1188 A/C Polymorphism and Cancer Risk

description: <b><i>Background: </i></b>Because of inconsistent results from previous studies on the association of <i>IL-12B </i>+1188 A/C polymorphism with cancer risk, a meta-analysis was performed to assess the association. <b><i>Materials and Methods: </i></b>A literature search was performed to identify all relevant studies to May 31, 2012, with a restriction to English and Chinese publications. Pooled data were estimated using a random-effects model. <b><i>Results: </i></b>17 publications were included in the meta-analysis. The results indicated that the polymorphism was significantly associated with a decreased risk for overall cancer (odds ratio (OR), 95% confidence interval (CI): 0.86, 0.76-0.97, p = 0.007; 0.80, 0.68-0.95, p = 0.012; and 0.88, 0.78-0.99, p = 0.032, respectively for dominant model, recessive model, and allele analysis) or nasopharyngeal cancer and hepatocellular carcinoma. This association was also found in Asians (OR, 95% CI: 0.89, 0.80-0.99, p = 0.031; 0.82, 0.68-0.98, p = 0.027; and 0.89, 0.80-1.00, p = 0.047, respectively for dominant model, recessive model, and allele analysis), but not in Europeans and Americans. <b><i>Conclusion: </i></b>The present study indicates that the <i>IL-12B </i>+1188 A/C polymorphism could play a protective role in the development of cancer. More investigations involving various cancer types among various populations are needed.