cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17161595
title: Additional file 1 of Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin

description: Additional file 1: Table S1. Primer sequences for qRT-PCR. Table S2. Primer sequences for qRT-PCR. Table S3. The sequences of shRNA for NORAD. Table S4. Sequences of miR-224-3p mimic and inhibitor.
DOI: 10.26207/qpxv-5v60
title: Unraveling nested feedback loops in insect gaze stabilization (Data for manuscript)
DOI: 10.6084/m9.figshare.23983458
title: Additional file 2 of Molecular regulatory mechanism of key LncRNAs in subclinical mastitic cows with folic acid supplementation

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.23983458.v1
title: Additional file 2 of Molecular regulatory mechanism of key LncRNAs in subclinical mastitic cows with folic acid supplementation

description: Supplementary Material 2
DOI: 10.3886/e195744v1
title: Data and Code for: Migration and Innovation: Learning from Patent and Inventor Data

description: Research on
international migration and innovation relies heavily on inventor and patent
data, with “migrant inventors” attracting a great deal of attention, especially
for what concerns their role in easing the international transfer of knowledge.
This hides the fact that many of them move to their host country before
starting their inventive career or even before completing their education. We
discuss the conceptual and practical difficulties that stand in the way of investigating
other likely channels of influence of inventor’s migration on innovation,
namely the easing of skill shortages and the increase of variety in inventive
teams, firms, and location.
description: Inventors (and their patents) in different countries.
DOI: 10.6084/m9.figshare.7200200
title: Additional file 3: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S1. RNA-seq data and quality control. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7200200.v1
title: Additional file 3: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S1. RNA-seq data and quality control. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.7200209.v1
title: Additional file 4: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S2-S5. Table S2. Sixty-six significant GO terms (FDR &lt; 0.05) mapped by 266 up-regulated DEGs between CsINV5-OE and WT plants. Table S3. Fifty-five significant GO terms (FDR &lt; 0.05) mapped by 402 down-regulated DEGs between CsINV5-OE and WT plants. Table S4. Sixty-two significant GO terms (FDR &lt; 0.05) mapped by 1248 up-regulated DEGs between CsINV5-OE and WT plants in cold conditions condition. Table S5. Sixty-eight significant GO terms (FDR &lt; 0.05) mapped by 1479 down-regulated DEGs between CsINV5-OE and WT plants in cold conditions condition. (XLSX 27 kb)
DOI: 10.5066/p1gppjou
title: A geodatabase of Woodruff, K.D., and Christopher, M.J., 1982, Thickness of Regolith in the Delaware Piedmont: Delaware Geological Survey Open File Report No. 19, scale 1:24,000.

description: This Scientific Data Release is a spatial geodatabase containing Woodruff, K.D. Christopher, M.J., 1982, Thickness of Regolith in the Delaware Piedmont: Delaware Geological Survey Open File Report No. 19, scale 1:24,000, formatted to Geologic Map Schema (GeMS) standards. These geospatial data depict the total thickness (regolith) of both the loose, transported material and the weathered rock that overlies crystalline rocks of the Delaware Piedmont. Land-use planners of many kinds (including National Forest managers, developers, city and rural planners, and highway builders) need accurate geologic data with which to make informed decisions. This geodatabase was produced in support of the U.S. Geological Survey U.S. Geoframework Initiative in the Delaware River Basin. The project was funded as part of the National Cooperative Geologic Mapping Program.
DOI: 10.6084/m9.figshare.7200209
title: Additional file 4: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S2-S5. Table S2. Sixty-six significant GO terms (FDR &lt; 0.05) mapped by 266 up-regulated DEGs between CsINV5-OE and WT plants. Table S3. Fifty-five significant GO terms (FDR &lt; 0.05) mapped by 402 down-regulated DEGs between CsINV5-OE and WT plants. Table S4. Sixty-two significant GO terms (FDR &lt; 0.05) mapped by 1248 up-regulated DEGs between CsINV5-OE and WT plants in cold conditions condition. Table S5. Sixty-eight significant GO terms (FDR &lt; 0.05) mapped by 1479 down-regulated DEGs between CsINV5-OE and WT plants in cold conditions condition. (XLSX 27 kb)
DOI: 10.5281/zenodo.10684805
title: O'ZBEK XALQ CHOLG'ULARIDA ASARLARNI BADIIY HUSUSIYATLARI
DOI: 10.5281/zenodo.10684806
title: O'ZBEK XALQ CHOLG'ULARIDA ASARLARNI BADIIY HUSUSIYATLARI
DOI: 10.6084/m9.figshare.17161646
title: Additional file 1 of Exploration of the value of progesterone and progesterone/estradiol ratio on the hCG trigger day in predicting pregnancy outcomes of PCOS patients undergoing IVF/ICSI: a retrospective cohort study

description: Additional file 1.
DOI: 10.5281/zenodo.10684796
title: Spectral library of soils from Ribeiro da Serra and Tapada
DOI: 10.5281/zenodo.10684797
title: Spectral library of soils from Ribeiro da Serra and Tapada
DOI: 10.6084/m9.figshare.14540379
title: Functional identification of a rare vascular endothelial growth factor a (<i>VEGFA</i>) variant associating with the nonsyndromic cleft lip with/without cleft palate

description: Vascular endothelial growth factor A (VEGFA) is a crucial growth factor, which participates in multiple processes of human growth and development, such as angiogenesis and osteogenesis and is also necessary for development of palate. The purpose of this study was to investigate the effect of a rare <i>VEGFA</i> mutation (NM_001025366.2 773 T &gt; C p.Val258Ala) on the cell functions and osteogenesis. Here, we found that the <i>VEGFA</i> mutation has adverse effects on the function of human embryonic palatal plate mesenchymal (HEPM) cells, and may affect the development of palate. The <i>VEGFA</i> mutation has adverse effects on promoting cell proliferation and migration and inhibiting apoptosis in HEPM and HEK–293 cells. In addition, the mutant <i>VEGFA</i> allele has a negative influence on osteogenesis. Taken together, the rare variant of <i>the VEGFA</i> gene had an adverse effect on cell functions and osteogenesis, which may impact the development of the palate. And these findings suggested that <i>VEGFA</i> mutation (c.773 T &gt; C) may lead to nonsyndromic cleft lip with or without cleft palate and also provide a new insight into the mechanism of <i>VEGFA</i> gene in osteogenesis and palatogenesis.
DOI: 10.6084/m9.figshare.7724561.v1
title: MOESM1 of ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

description: Additional file 1: Figure S1. ITK inhibitor HY-11066 inhibits the proliferation of malignant T-cell lymphoma cell lines. Jurkat, Hut-78 and H9 cells were treated with the indicated concentrations of the ITK inhibitor HY-11066. The cell viability was measured using the Cell Titer-Glo Luminescent Cell Viability Assay. Viable cells (% control) were calculated. Data are expressed as Mean ± SD and representative of three independent experiments. Figure S2. Transwell invasion and migration assays of ITK inhibition in Karpas-299 cells. (A) Karpas-299 cells transfected with vectors carrying ITK shRNA (shITK-34467) or shControl were subjected to invasion assays and migration assays using Transwell chambers coated with Matrigel and Transwell chambers without Matrigel respectively. The cells were monitored by a CellTiter-Glo Luminescent Cell Viability Assay. Data are expressed as Mean ± SD and representative of three independent experiments. Statistical analysis was performed using Student’s t test. *P &lt; 0.05, **P &lt; 0.001 compared with the control group. (B) Migration and invasion assay images of Fig. 3c, d. Figure S3. The chemosensitivity to common chemotherapeutic agents in Karpas-299 cells after the inhibition of ITK. Karpas-299 cells transfected with shITK (shITK-34467) or shControl were exposed to vincristine (A) or doxorubicin (B) for 72 h. Cell viability was measured using a Cell Titer-Glo Luminescent Cell Viability Assay. Data are expressed as Mean ± SD and representative of three independent experiments. Statistical analysis was performed using Student’s t test. *P &lt; 0.05, **P &lt; 0.001 compared with the control group. Figure S4. ITK inhibitor BMS-509744 have no effect on the apoptosis and cell cycle arrest in karpas-299 cells. (A) Karpas-299 cells (2 × 105) were treated with BMS-509744 (3 μM, 5 μM, or 8 μM) for 24 and 48 h, and apoptotic cells were quantified using flow cytometry. (B) Karpas-299 cells (2 × 105) were treated with different concentrations of BMS-509744 (3 μM, 5 μM, or 8 μM) for 24 h, and the cell cycle profiles of the populations were measured using flow cytometry. Data are expressed as Mean ± SD and representative of three independent experiments. Statistical analysis was performed using Student’s t test. *P &lt; 0.05, **P &lt; 0.001 compared with the control group.
DOI: 10.6084/m9.figshare.17161649
title: Additional file 2 of Exploration of the value of progesterone and progesterone/estradiol ratio on the hCG trigger day in predicting pregnancy outcomes of PCOS patients undergoing IVF/ICSI: a retrospective cohort study

description: Additional file 2.
DOI: 10.6084/m9.figshare.7724576.v1
title: MOESM3 of ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

description: Additional file 3: Table S2. Patientsâ characteristics and correlations with the expression of p-PLCÎł1.
DOI: 10.6084/m9.figshare.7200248.v1
title: Additional file 7: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S8. Amino acid sequences of the SAI proteins used for conserved domain analysis. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.16632891.v1
title: Additional file 6 of Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

description: Additional file 6: Table S5: Tissue-specific methQTLs for the four tissues/cell types.
DOI: 10.6084/m9.figshare.7200224.v1
title: Additional file 5: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S6. Partial DEGs (FDRâ &lt;â 0.05, log2FC) in CsINV5-OE plants compared to WT plants in normal and cold conditions. (XLSX 21 kb)
DOI: 10.6084/m9.figshare.7724561
title: MOESM1 of ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

description: Additional file 1: Figure S1. ITK inhibitor HY-11066 inhibits the proliferation of malignant T-cell lymphoma cell lines. Jurkat, Hut-78 and H9 cells were treated with the indicated concentrations of the ITK inhibitor HY-11066. The cell viability was measured using the Cell Titer-Glo Luminescent Cell Viability Assay. Viable cells (% control) were calculated. Data are expressed as Mean ± SD and representative of three independent experiments. Figure S2. Transwell invasion and migration assays of ITK inhibition in Karpas-299 cells. (A) Karpas-299 cells transfected with vectors carrying ITK shRNA (shITK-34467) or shControl were subjected to invasion assays and migration assays using Transwell chambers coated with Matrigel and Transwell chambers without Matrigel respectively. The cells were monitored by a CellTiter-Glo Luminescent Cell Viability Assay. Data are expressed as Mean ± SD and representative of three independent experiments. Statistical analysis was performed using Student’s t test. *P &lt; 0.05, **P &lt; 0.001 compared with the control group. (B) Migration and invasion assay images of Fig. 3c, d. Figure S3. The chemosensitivity to common chemotherapeutic agents in Karpas-299 cells after the inhibition of ITK. Karpas-299 cells transfected with shITK (shITK-34467) or shControl were exposed to vincristine (A) or doxorubicin (B) for 72 h. Cell viability was measured using a Cell Titer-Glo Luminescent Cell Viability Assay. Data are expressed as Mean ± SD and representative of three independent experiments. Statistical analysis was performed using Student’s t test. *P &lt; 0.05, **P &lt; 0.001 compared with the control group. Figure S4. ITK inhibitor BMS-509744 have no effect on the apoptosis and cell cycle arrest in karpas-299 cells. (A) Karpas-299 cells (2 × 105) were treated with BMS-509744 (3 μM, 5 μM, or 8 μM) for 24 and 48 h, and apoptotic cells were quantified using flow cytometry. (B) Karpas-299 cells (2 × 105) were treated with different concentrations of BMS-509744 (3 μM, 5 μM, or 8 μM) for 24 h, and the cell cycle profiles of the populations were measured using flow cytometry. Data are expressed as Mean ± SD and representative of three independent experiments. Statistical analysis was performed using Student’s t test. *P &lt; 0.05, **P &lt; 0.001 compared with the control group.
DOI: 10.5281/zenodo.10684809
title: YOSHLAR MA'NAVIYATINI YUKSALTIRISHDA FOLKLOR SAN'ATINING O'RNI
DOI: 10.5281/zenodo.10684810
title: YOSHLAR MA'NAVIYATINI YUKSALTIRISHDA FOLKLOR SAN'ATINING O'RNI
DOI: 10.6084/m9.figshare.17161651.v1
title: Additional file 8 of Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity

description: Additional file 8: Table S9. Associations of gut bacterial genera with US exposure, stratified by birth place, among the first generation immigrants.
DOI: 10.6084/m9.figshare.7724570
title: MOESM2 of ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

description: Additional file 2: Table S1. Patientsâ characteristics and correlations with the expression of p-ZAP70.
DOI: 10.6084/m9.figshare.7200248
title: Additional file 7: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S8. Amino acid sequences of the SAI proteins used for conserved domain analysis. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.17161709.v1
title: Additional file 4 of Immune landscape of advanced gastric cancer tumor microenvironment identifies immunotherapeutic relevant gene signature

description: Additional file 4.
DOI: 10.6084/m9.figshare.17161709
title: Additional file 4 of Immune landscape of advanced gastric cancer tumor microenvironment identifies immunotherapeutic relevant gene signature

description: Additional file 4.
DOI: 10.6084/m9.figshare.7724570.v1
title: MOESM2 of ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

description: Additional file 2: Table S1. Patientsâ characteristics and correlations with the expression of p-ZAP70.
DOI: 10.6084/m9.figshare.7200224
title: Additional file 5: of CsINV5, a tea vacuolar invertase gene enhances cold tolerance in transgenic Arabidopsis

description: Table S6. Partial DEGs (FDRâ &lt;â 0.05, log2FC) in CsINV5-OE plants compared to WT plants in normal and cold conditions. (XLSX 21 kb)
DOI: 10.6084/m9.figshare.17161703.v1
title: Additional file 2 of Immune landscape of advanced gastric cancer tumor microenvironment identifies immunotherapeutic relevant gene signature

description: Additional file 2.
DOI: 10.6084/m9.figshare.20307418.v1
title: Additional file 1 of Identifying the role of transient receptor potential channels (TRPs) in kidney renal clear cell carcinoma and their potential therapeutic significances using genomic and transcriptome analyses

description: Additional file 1. Table S1: The results of differentially expressed genes between 539 KIRC samples and 72 normal samples from the TCGA database. Table S2: The results of univariate Cox regression analysis of 526 KIRC samples from the TCGA database. Table S3: The results of multivariate Cox regression analysis.
DOI: 10.6084/m9.figshare.6682367.v1
title: Peritumoral Monocytes Induce Cancer Cell Autophagy to Facilitate the Progression of Human Hepatocellular Carcinoma

description: Macroautophagy/autophagy is an important catabolic process mediating cellular homeostasis and plays critical roles in cancer development. Whereas autophagy has been widely studied in various pathological models, little is known about the distribution, clinical significance and regulatory mechanism of this process in human hepatocellular carcinoma (HCC). In the present study, we found that tumor tissues exhibited significantly increased levels of autophagy compared with non-tumor tissues, and cancer cells with higher levels of autophagy were predominantly enriched in the invading edge regions of human HCC. Increased MAP1LC3B/LC3B expression in the invading edge regions was significantly correlated with a higher density of closely located monocytes, and TNF and IL1B derived from tumor-activated monocytes synergistically induced cancer cell autophagy in the invading edge regions of HCC. Monocyte-elicited autophagy induced the epithelial-mesenchymal transition (EMT) of cancer cells and promoted tumor metastasis by activating the NFKB-SNAI1 signaling pathway. Moreover, the increase of LC3B<sup>+</sup> cancer cells in the invading edge areas was associated with high mortality and reduced survival of patients with HCC. These findings indicated that cancer cell autophagy is regulated by a collaborative interaction between tumor and immune cell components in distinct HCC microenvironments, thus allowing the inflammatory monocytes to be rerouted in a tumor-promoting direction.
DOI: 10.6084/m9.figshare.17161648
title: Additional file 7 of Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity

description: Additional file 7: Table S8. Associations of gut bacterial genera with obesity (BMI), stratified by birth place, among the first generation immigrants.
DOI: 10.6084/m9.figshare.23977800
title: Train and test data from EBSD observation from A machine learning study on the fatigue crack path of short crack on an α titanium alloy

description: In the present study, a physics-informed neural network model based on Bayesian hyperparameter optimization is proposed for the prediction of short crack growth paths. A large number of cyclic loadings at a lower amplitude were applied to an α titanium sample by ultrasonic fatigue machine to ensure a sufficient amount of data for machine learning. The grain size, grain orientation, grain boundary direction on the path, as well as crack growth direction, were selected as feature data for training the prediction model. The optimizations of the size ratio and the angle operation were conducted to compare different data processing methods, respectively. After evaluation, eventually, a model for predicting crack growth path is obtained with a reliable performance of 10% tolerance on the path angle at each grain boundary. And the prediction effect of the proposed model is better than that of some classic machine learning models and slip trace analysis.This article is part of the theme issue 'Physics-informed machine learning and its structural integrity applications (Part 1)'.
DOI: 10.6084/m9.figshare.20307484.v1
title: Additional file 12 of A functional reference map of the RNF8 interactome in cancer

description: Additional file 12. Supplementary information_2: All targets identified by databases and LC-MS.
DOI: 10.6084/m9.figshare.20307496.v1
title: Additional file 14 of A functional reference map of the RNF8 interactome in cancer

description: Additional file 14. Supplementary information_4: All original gel images.
DOI: 10.6084/m9.figshare.20307484
title: Additional file 12 of A functional reference map of the RNF8 interactome in cancer

description: Additional file 12. Supplementary information_2: All targets identified by databases and LC-MS.
DOI: 10.6084/m9.figshare.20307490.v1
title: Additional file 13 of A functional reference map of the RNF8 interactome in cancer

description: Additional file 13. Supplementary information_3: Proteomics data.
DOI: 10.6084/m9.figshare.20307496
title: Additional file 14 of A functional reference map of the RNF8 interactome in cancer

description: Additional file 14. Supplementary information_4: All original gel images.
DOI: 10.6084/m9.figshare.17162283.v1
title: Cyclic tensile strain facilitates proliferation and migration of human aortic smooth muscle cells and reduces their apoptosis via miRNA-187-3p

description: The cardiovascular is a system that contains extremely complex mechanical factors, in which the circulatory flow of blood has rich mechanical laws. Many studies have revealed that mechanical factors play a very important role in the process of revascularization. Hence, it is essential to investigate the mechanical factors in the process of revascularization in depth. A cyclic tensile strain (CTS) was applied to human aortic smooth muscle cells (HASMCs) at a frequency of 1 Hz and amplitudes of 5%, 10% and 15%, respectively. SmallRNA-seq was used to identify differentially expressed miRNAs (DE-miRNAs) responding to CTS in HASMCs. Starbase database predicted the target genes of DE-miRNAs. Metascape was applied for GO and KEGG pathway enrichment analysis and protein–protein interaction network construction. The proliferation and migration of CTS-treated HASMCs were significantly enhanced, and apoptosis were significantly reduced compared to the control group. SmallRNA-seq results demonstrated that 55, 16 and 16 DE-miRNAs were present in 5%, 10% and 15% CTS-treated HASMCs, respectively. Compared to controls, with miR-26a-2-3p and miR-187-3p being the intersection of these DE-miRNAs. Starbase database identified 189 common target genes for miR-26a-2-3p and miR-187-3p. Common target genes are mainly enriched in the basolateral plasma membrane and endocytosis. Further, <i>in vitro</i> experiments exhibited that CTS upregulated miR-187-3p expression, and miR-187-3p enhanced the proliferation and migration of HASMCs and reduced their apoptosis. It is suggested that miR-187-3p may be an important target for CTS participate in the process of cardiovascular disease.