cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1409398.v224
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399199
title: The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility

description: Dataset for evaluation of diagnostic accuracy of LAM antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility
DOI: 10.6084/m9.figshare.1399196
title: Meta Path Topological Features

description: Data set for link prediction using machine learning algorithms built upon meta-path topological features
DOI: 10.6084/m9.figshare.1399199.v1
title: The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility

description: Dataset for evaluation of diagnostic accuracy of LAM antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility
DOI: 10.6084/m9.figshare.1399208.v6
title: Destabilization of pluripotency in the absence of Mad2l2

description: The induction and maintenance of pluripotency requires the expression of several core factors at appropriate levels (Oct4, Sox2, Klf4, Prdm14). A subset of these proteins (Oct4, Sox2, Prdm14) also plays crucial roles for the establishment of primordial germ cells (PGCs). Here we demonstrate that the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs), depending on the growth conditions. Mad2l2<sup>−/−</sup> ESCs were unstable in LIF/serum medium, and differentiated into primitive endoderm. However, they could be stably propagated using small molecule inhibitors of MAPK signaling. Several components of the MAPK cascade were up- or downregulated even in undifferentiated Mad2l2<sup>−/−</sup> ESCs. Global levels of repressive histone H3 variants were increased in mutant ESCs, and the epigenetic signatures on pluripotency-, primitive endoderm-, and MAPK-related loci differed. Thus, H3K9me2 repressed the Nanog promoter, while the promoter of Gata4 lost H3K27me3 and became de-repressed in LIF/serum condition. Promoters associated with genes involved in MAPK signaling also showed misregulation of these histone marks. Such epigenetic modifications could be indirect consequences of mutating Mad2l2. However, our previous observations suggested the histone methyltransferases as direct (G9a) or indirect (Ezh2) targets of Mad2l2. In effect, the intricate balance necessary for pluripotency becomes perturbed in the absence of Mad2l2.
DOI: 10.6084/m9.figshare.1409398.v225
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399185
title: GlobWave multimission corrected Significant Wave Height for January, 2002

description: The complete GlobWave dataset is found at: ftp://ftp.ifremer.fr/ifremer/cersat/products/swath/altimeters/waves/data/ For access please consult: globwave.ifremer.fr/products/globwave-satellite-data
DOI: 10.6084/m9.figshare.1399186
title: Puccini and the Music Boxes

description: ABSTRACTThis article reveals the source for two major themes in <i>Madama Butterfly</i> – one associated with Butterfly herself, the other with her patrimony. The assumption has been that Puccini based these themes on Japanese melodies, but his source was actually a Swiss music box playing Chinese tunes. Specific moments in the opera indicate that Puccini was aware of the titles of these tunes. The sound of music boxes in <i>Butterfly</i> and <i>Turandot</i> suggests previously unnoticed connections between these operas. The music-box melodies may be traced to Fritz Bovet's transcriptions. Puccini encountered ‘Jasmine Flower’ on these boxes, and in <i>Turandot</i> reaffirmed its status as the token of Chinese music.
DOI: 10.6084/m9.figshare.1399208.v7
title: Destabilization of pluripotency in the absence of Mad2l2

description: The induction and maintenance of pluripotency requires the expression of several core factors at appropriate levels (Oct4, Sox2, Klf4, Prdm14). A subset of these proteins (Oct4, Sox2, Prdm14) also plays crucial roles for the establishment of primordial germ cells (PGCs). Here we demonstrate that the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs), depending on the growth conditions. Mad2l2<sup>−/−</sup> ESCs were unstable in LIF/serum medium, and differentiated into primitive endoderm. However, they could be stably propagated using small molecule inhibitors of MAPK signaling. Several components of the MAPK cascade were up- or downregulated even in undifferentiated Mad2l2<sup>−/−</sup> ESCs. Global levels of repressive histone H3 variants were increased in mutant ESCs, and the epigenetic signatures on pluripotency-, primitive endoderm-, and MAPK-related loci differed. Thus, H3K9me2 repressed the Nanog promoter, while the promoter of Gata4 lost H3K27me3 and became de-repressed in LIF/serum condition. Promoters associated with genes involved in MAPK signaling also showed misregulation of these histone marks. Such epigenetic modifications could be indirect consequences of mutating Mad2l2. However, our previous observations suggested the histone methyltransferases as direct (G9a) or indirect (Ezh2) targets of Mad2l2. In effect, the intricate balance necessary for pluripotency becomes perturbed in the absence of Mad2l2.
DOI: 10.6084/m9.figshare.1409398.v226
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399196.v1
title: Meta-path topological features

description: Data set for link prediction using machine learning algorithms built upon meta-path topological features
DOI: 10.6084/m9.figshare.1399208.v8
title: Destabilization of pluripotency in the absence of Mad2l2

description: The induction and maintenance of pluripotency requires the expression of several core factors at appropriate levels (Oct4, Sox2, Klf4, Prdm14). A subset of these proteins (Oct4, Sox2, Prdm14) also plays crucial roles for the establishment of primordial germ cells (PGCs). Here we demonstrate that the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs), depending on the growth conditions. Mad2l2<sup>−/−</sup> ESCs were unstable in LIF/serum medium, and differentiated into primitive endoderm. However, they could be stably propagated using small molecule inhibitors of MAPK signaling. Several components of the MAPK cascade were up- or downregulated even in undifferentiated Mad2l2<sup>−/−</sup> ESCs. Global levels of repressive histone H3 variants were increased in mutant ESCs, and the epigenetic signatures on pluripotency-, primitive endoderm-, and MAPK-related loci differed. Thus, H3K9me2 repressed the Nanog promoter, while the promoter of Gata4 lost H3K27me3 and became de-repressed in LIF/serum condition. Promoters associated with genes involved in MAPK signaling also showed misregulation of these histone marks. Such epigenetic modifications could be indirect consequences of mutating Mad2l2. However, our previous observations suggested the histone methyltransferases as direct (G9a) or indirect (Ezh2) targets of Mad2l2. In effect, the intricate balance necessary for pluripotency becomes perturbed in the absence of Mad2l2.
DOI: 10.6084/m9.figshare.1409398.v227
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399185.v1
title: GlobWave multimission corrected Significant Wave Height for January, 2002

description: The complete GlobWave dataset is found at: ftp://ftp.ifremer.fr/ifremer/cersat/products/swath/altimeters/waves/data/ For access please consult: globwave.ifremer.fr/products/globwave-satellite-data
DOI: 10.6084/m9.figshare.1399186.v1
title: Puccini and the Music Boxes

description: ABSTRACTThis article reveals the source for two major themes in <i>Madama Butterfly</i> – one associated with Butterfly herself, the other with her patrimony. The assumption has been that Puccini based these themes on Japanese melodies, but his source was actually a Swiss music box playing Chinese tunes. Specific moments in the opera indicate that Puccini was aware of the titles of these tunes. The sound of music boxes in <i>Butterfly</i> and <i>Turandot</i> suggests previously unnoticed connections between these operas. The music-box melodies may be traced to Fritz Bovet's transcriptions. Puccini encountered ‘Jasmine Flower’ on these boxes, and in <i>Turandot</i> reaffirmed its status as the token of Chinese music.
DOI: 10.6084/m9.figshare.1399196.v3
title: Meta Path Topological Features

description: Data set for link prediction using machine learning algorithms built upon meta-path topological features
DOI: 10.6084/m9.figshare.1399208.v9
title: Destabilization of pluripotency in the absence of Mad2l2

description: The induction and maintenance of pluripotency requires the expression of several core factors at appropriate levels (Oct4, Sox2, Klf4, Prdm14). A subset of these proteins (Oct4, Sox2, Prdm14) also plays crucial roles for the establishment of primordial germ cells (PGCs). Here we demonstrate that the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs), depending on the growth conditions. Mad2l2<sup>−/−</sup> ESCs were unstable in LIF/serum medium, and differentiated into primitive endoderm. However, they could be stably propagated using small molecule inhibitors of MAPK signaling. Several components of the MAPK cascade were up- or downregulated even in undifferentiated Mad2l2<sup>−/−</sup> ESCs. Global levels of repressive histone H3 variants were increased in mutant ESCs, and the epigenetic signatures on pluripotency-, primitive endoderm-, and MAPK-related loci differed. Thus, H3K9me2 repressed the Nanog promoter, while the promoter of Gata4 lost H3K27me3 and became de-repressed in LIF/serum condition. Promoters associated with genes involved in MAPK signaling also showed misregulation of these histone marks. Such epigenetic modifications could be indirect consequences of mutating Mad2l2. However, our previous observations suggested the histone methyltransferases as direct (G9a) or indirect (Ezh2) targets of Mad2l2. In effect, the intricate balance necessary for pluripotency becomes perturbed in the absence of Mad2l2.
DOI: 10.6084/m9.figshare.1399185.v2
title: GlobWave multimission corrected Significant Wave Height for January through March, 2002

description: The complete GlobWave dataset is found at: ftp://ftp.ifremer.fr/ifremer/cersat/products/swath/altimeters/waves/data/ For access please consult: globwave.ifremer.fr/products/globwave-satellite-data
DOI: 10.6084/m9.figshare.1399186.v3
title: Puccini and the Music Boxes

description: ABSTRACTThis article reveals the source for two major themes in <i>Madama Butterfly</i> – one associated with Butterfly herself, the other with her patrimony. The assumption has been that Puccini based these themes on Japanese melodies, but his source was actually a Swiss music box playing Chinese tunes. Specific moments in the opera indicate that Puccini was aware of the titles of these tunes. The sound of music boxes in <i>Butterfly</i> and <i>Turandot</i> suggests previously unnoticed connections between these operas. The music-box melodies may be traced to Fritz Bovet's transcriptions. Puccini encountered ‘Jasmine Flower’ on these boxes, and in <i>Turandot</i> reaffirmed its status as the token of Chinese music.
DOI: 10.6084/m9.figshare.1399186.v2
title: Puccini and the Music Boxes

description: ABSTRACTThis article reveals the source for two major themes in <i>Madama Butterfly</i> – one associated with Butterfly herself, the other with her patrimony. The assumption has been that Puccini based these themes on Japanese melodies, but his source was actually a Swiss music box playing Chinese tunes. Specific moments in the opera indicate that Puccini was aware of the titles of these tunes. The sound of music boxes in <i>Butterfly</i> and <i>Turandot</i> suggests previously unnoticed connections between these operas. The music-box melodies may be traced to Fritz Bovet's transcriptions. Puccini encountered ‘Jasmine Flower’ on these boxes, and in <i>Turandot</i> reaffirmed its status as the token of Chinese music.
DOI: 10.6084/m9.figshare.1399184
title: C. angaria de novo protein coding gene annotations

description: C. angaria protein coding gene annotations from the MAKER2 annotation pipeline used to annotate the C. remanei genome
DOI: 10.6084/m9.figshare.1399196.v2
title: Comparative Analysis of Provenance RDF models

description: Data set for link prediction using machine learning algorithms built upon meta-path topological features
DOI: 10.6084/m9.figshare.1399184.v1
title: C. angaria de novo protein coding gene annotations

description: C. angaria protein coding gene annotations from the MAKER2 annotation pipeline used to annotate the C. remanei genome
DOI: 10.6084/m9.figshare.1409398.v228
title: ABO phenotype protected reproduction as it is based on fucosylations.

description: The molecular biological relationship between human fertility and ABO(H) blood group phenotype formation becomes evident with the rare (Oh) or <i>Bombay</i> blood type, which based on the history of his own family, Charles Darwin would have interpreted as resulting from reduced fertility in consanguinities. In its native form, the <i>Bombay</i> type occurs in individuals with an extremely rare genotype (h/h;se/se), by which the fucosyltransferases FUT1 and FUT2 are not produced due to point mutations. These enzymes, encoded on chromosome 19, are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, while the fucosyl residues provide the functional-structural basis for the formation of any ABO(H) phenotype on the cell surface or in secretions and plasma proteins. Immunoglobulins are also heavily fucosylated, and via developmental variation of the positions between the cell surfaces and the heavy chains of immunoglobulins, fucosyl residues appear to augment or reduce antibody-mediated cellular cytotoxicity involving physiological anti-self-reactivity; moreover, by regulating the assembly and intracellular signaling of precursor B cell receptors, the core fucosylation of immunoglobulin heavy chains represents a key mechanism in clonal selection. In fact, the seminal plasma of leucospermic infertile men has been reported to exert high levels of poorly core-fucosylated IgG. Consequently, in <i>Bombay </i>type individuals, the non-somatic glycosylation processes of embryogenic stem cell-to-germ cell transformation, which involve the modification and <i>O</i>-fucosylation of epidermal growth factor (EGF), are most likely exposed to metabolic competition with multiple glycosidic sites of poorly fucosylated, glycan-depleted immunoglobulins that might promote increased anti-self-reactive cytotoxicity.
DOI: 10.6084/m9.figshare.1399185.v3
title: GlobWave multimission corrected Significant Wave Height for January through March, 2002

description: The complete GlobWave dataset is found at: ftp://ftp.ifremer.fr/ifremer/cersat/products/swath/altimeters/waves/data/ For access please consult: globwave.ifremer.fr/products/globwave-satellite-data