cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.1600888
title: Facile Synthesis of Some New Pyrazole-Based 2-Thioxo-4-thiazolidinone

description: 5-Ethoxymethylene-2-thioxo-4-thiazolidinone (<b>1</b>) reacts with hydrazine hydrate at room temperature to afford 5-(hydrazinylmethylene)-2-thioxo-4-thiazolidinone (<b>3)</b>. Compound <b>3</b> condensed with different aromatic aldehydes <b>6a–d</b> in ethanol in the presence of a few drops of piperidine to give the corresponding Schiff’s bases <b>7a–d</b>. On the other hand, compound <b>3</b> reacts with o-hydroxybenzaldehyde derivatives <b>8a</b> and <b>8b</b> in refluxing ethanol catalyzed by a few drops of piperidine to yield 1H-inadzolyl-2-thioxo-4-thiazolidinones <b>9a</b> and <b>9b</b>. Reaction of compound <b>3</b> with α-ketoesters <b>10a</b> and <b>10b</b> or α-diketones <b>10c–e</b> in refluxing glacial acetic acid furnished the pyrazolyl-2-thioxo-4-thiazolidinone derivatives <b>11a–e</b>. Also, compound <b>3</b> reacts with some different enaminones <b>12a–f</b> in refluxing glacial acetic acid to afford the new pyrazolyl-2-thioxo-4-thiazolidinone derivatives <b>13a–f</b>. Pyrazoles <b>15a–d</b> was obtained via reaction of compound <b>3</b> with chalcones <b>14a–d</b> in dimethylformamide (DMF). The structures of all the newly synthesized products were confirmed on the basis of their elemental and spectral data, and a plausible mechanism has been postulated to account for their formation.
DOI: 10.6084/m9.figshare.1600888.v2
title: Facile Synthesis of Some New Pyrazole-Based 2-Thioxo-4-thiazolidinone

description: 5-Ethoxymethylene-2-thioxo-4-thiazolidinone (<b>1</b>) reacts with hydrazine hydrate at room temperature to afford 5-(hydrazinylmethylene)-2-thioxo-4-thiazolidinone (<b>3)</b>. Compound <b>3</b> condensed with different aromatic aldehydes <b>6a–d</b> in ethanol in the presence of a few drops of piperidine to give the corresponding Schiff’s bases <b>7a–d</b>. On the other hand, compound <b>3</b> reacts with o-hydroxybenzaldehyde derivatives <b>8a</b> and <b>8b</b> in refluxing ethanol catalyzed by a few drops of piperidine to yield 1H-inadzolyl-2-thioxo-4-thiazolidinones <b>9a</b> and <b>9b</b>. Reaction of compound <b>3</b> with α-ketoesters <b>10a</b> and <b>10b</b> or α-diketones <b>10c–e</b> in refluxing glacial acetic acid furnished the pyrazolyl-2-thioxo-4-thiazolidinone derivatives <b>11a–e</b>. Also, compound <b>3</b> reacts with some different enaminones <b>12a–f</b> in refluxing glacial acetic acid to afford the new pyrazolyl-2-thioxo-4-thiazolidinone derivatives <b>13a–f</b>. Pyrazoles <b>15a–d</b> was obtained via reaction of compound <b>3</b> with chalcones <b>14a–d</b> in dimethylformamide (DMF). The structures of all the newly synthesized products were confirmed on the basis of their elemental and spectral data, and a plausible mechanism has been postulated to account for their formation.
DOI: 10.6084/m9.figshare.1600888.v1
title: Facile Synthesis of Some New Pyrazole-Based 2-Thioxo-4-thiazolidinone

description: 5-Ethoxymethylene-2-thioxo-4-thiazolidinone (<b>1</b>) reacts with hydrazine hydrate at room temperature to afford 5-(hydrazinylmethylene)-2-thioxo-4-thiazolidinone (<b>3)</b>. Compound <b>3</b> condensed with different aromatic aldehydes <b>6a–d</b> in ethanol in the presence of a few drops of piperidine to give the corresponding Schiff’s bases <b>7a–d</b>. On the other hand, compound <b>3</b> reacts with o-hydroxybenzaldehyde derivatives <b>8a</b> and <b>8b</b> in refluxing ethanol catalyzed by a few drops of piperidine to yield 1H-inadzolyl-2-thioxo-4-thiazolidinones <b>9a</b> and <b>9b</b>. Reaction of compound <b>3</b> with α-ketoesters <b>10a</b> and <b>10b</b> or α-diketones <b>10c–e</b> in refluxing glacial acetic acid furnished the pyrazolyl-2-thioxo-4-thiazolidinone derivatives <b>11a–e</b>. Also, compound <b>3</b> reacts with some different enaminones <b>12a–f</b> in refluxing glacial acetic acid to afford the new pyrazolyl-2-thioxo-4-thiazolidinone derivatives <b>13a–f</b>. Pyrazoles <b>15a–d</b> was obtained via reaction of compound <b>3</b> with chalcones <b>14a–d</b> in dimethylformamide (DMF). The structures of all the newly synthesized products were confirmed on the basis of their elemental and spectral data, and a plausible mechanism has been postulated to account for their formation.
DOI: 10.6084/m9.figshare.1599840
title: Impostor Syndrome 2015

description: My lecture given at Columbia University on the intersection of race, gender and the impostor syndrome
DOI: 10.6084/m9.figshare.1599840.v1
title: Impostor Syndrome 2015

description: My lecture given at Columbia University on the intersection of race, gender and the impostor syndrome
DOI: 10.6084/m9.figshare.1599833
title: Charleston Conference 2015 Presentations

description: Slides with notes from 2015 Charleston Conference workshops and notes.
DOI: 10.6084/m9.figshare.1599839
title: ECOL2050- The Relationship Between Sunlight and Vegetation Abundance

description: This experiment was conducted over the course of two days. 200 quadrates were done in grasslands(100) and woodlots(100). The temperature and cloud cover was consistantly 14 degrees celcius and partially cloudy. Quadrates were chosen via random number generator, first 1-4 N-W, then again 1-20 to determine the amount of steps needed to be taken in set direction. <br><br>This experiment measures the amount of sunlight an area recieves and the abundance of living vegetation present.
DOI: 10.6084/m9.figshare.1599839.v1
title: ECOL2050- The Relationship Between Sunlight and Vegetation Abundance

description: This experiment was conducted over the course of two days. 200 quadrates were done in grasslands(100) and woodlots(100). The temperature and cloud cover was consistantly 14 degrees celcius and partially cloudy. Quadrates were chosen via random number generator, first 1-4 N-W, then again 1-20 to determine the amount of steps needed to be taken in set direction. <br><br>This experiment measures the amount of sunlight an area recieves and the abundance of living vegetation present.
DOI: 10.6084/m9.figshare.1599826
title: figure raw data

description: raw data for figures used in manuscript. For description and abbrevations see the figure legends in the manuscript.
DOI: 10.6084/m9.figshare.1599826.v1
title: figure raw data

description: raw data for figures used in manuscript. For description and abbrevations see the figure legends in the manuscript.
DOI: 10.6084/m9.figshare.1599798
title: ScleroticScatter Data

description: Data collected for the analysis provided in the article "Sclerotic scatter limbal arc is more easily elicited under mesopic rather that photopic conditions" by Eric Denion, Anne-Laure Lux, Frédéric Mouriaux and Guillaume Béraud. When participants had a second examination, a number 2 was added to their identifying letter.
DOI: 10.6084/m9.figshare.1599797
title: BioSharing: examples of use in NIH BD2K CEDAR, BioCADDIE and ELIXIR

description: BioSharing (http://www.biosharing.org) is a curated, web-based, searchable portal of over 1,300 records describing content standards, databases and data policies in the life sciences, broadly encompassing the biological, natural and biomedical sciences. Among many features, the records can be searched and filtered, or grouped via the ‘Collection’ feature according to field of interest. An example is the Collection curated with the NIH BD2K bioCADDIE project, for various purposes. First, to select and track content standards that have been reviewed during the creation of the metadata model underpinning the Data Discovery Index. Second, as the work progresses and the prototype Index harvests dataset descriptors from different databases, the Collection will be extended to include the descriptions of these databases, including which (if any) standards they implement. This is key to support one of the bioCADDIE project use cases: to allow the searching and filtering of datasets that are compliant to a given community standard. Despite a growing set of standard guidelines and formats for describing their experiments, the barriers to authoring the experimental metadata necessary for sharing and interpreting datasets are tremendously high. Understanding how to comply with these standards takes time and effort and researchers view this as a burden that may benefit other scientists, but not themselves. To tackle this, with and for the NIH BD2K CEDAR project, we will explore methods to serve machine-readable versions of these standards that can inform the creation of metadata templates, rendering standards invisible to the researchers and driving them to strive for easier authoring of the experimental metadata. Lastly, as part of the ELIXIR-UK Node BioSharing is being developed to be the ELIXIR Standards Registry and will be progressively cross-linked to other registries, such as the ELIXIR Tools and Services Registry and the ELIXIR Training e-Support System (TeSS).
DOI: 10.6084/m9.figshare.1599798.v1
title: ScleroticScatter Data

description: Data collected for the analysis provided in the article "Sclerotic scatter limbal arc is more easily elicited under mesopic rather that photopic conditions" by Eric Denion, Anne-Laure Lux, Frédéric Mouriaux and Guillaume Béraud. When participants had a second examination, a number 2 was added to their identifying letter.
DOI: 10.6084/m9.figshare.1599796
title: BioSharing Posters

description: BioSharing Posters
DOI: 10.6084/m9.figshare.1599794
title: Data files from Chaudhuri, J. et al. Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci. Rep. 5, 17676; doi: 10.1038/srep17676 (2015).

description: Data files
DOI: 10.6084/m9.figshare.1599789
title: Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology

description: <b><i>Introduction</i></b>: Dead enzymes are gene products (proteins) that lack key residues required for catalytic activity. In the pre-genome era, dead enzymes were thought to occur only rarely. However, they now have been shown to represent upwards of 10% of the total enzyme population in many families. The aldehyde dehydrogenase (ALDH) gene family encodes proteins that, depending on the isozyme, may be either catalytically-active or -inactive. Importantly, several ALDHs exhibit biological activities independent of their catalytic activity. For many of these, the physiological and pathophysiological functions remain to be established.<b><i>Areas covered</i>:</b> This article reviews the non-enzymatic functions of the ALDH superfamily. In addition, a search for additional non-catalytic ALDH records is undertaken. Our computational analyses reveal that there are currently 182 protein records (divided into 19 groups) that meet the criteria for dead enzymes.<b><i>Expert Opinion</i>:</b> Dead enzymes have the potential to exert biological actions through protein-protein interaction and allosteric modulation of the activity of an active enzyme. In addition, a dead enzyme may also influence availability of substrate for other active enzymes by sequestering substrate, and/or anchoring the substrate to a particular subcellular space. A large number of putatively non-catalytic ALDH proteins exist that warrant further study.
DOI: 10.6084/m9.figshare.1599789.v1
title: Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology

description: <b><i>Introduction</i></b>: Dead enzymes are gene products (proteins) that lack key residues required for catalytic activity. In the pre-genome era, dead enzymes were thought to occur only rarely. However, they now have been shown to represent upwards of 10% of the total enzyme population in many families. The aldehyde dehydrogenase (ALDH) gene family encodes proteins that, depending on the isozyme, may be either catalytically-active or -inactive. Importantly, several ALDHs exhibit biological activities independent of their catalytic activity. For many of these, the physiological and pathophysiological functions remain to be established.<b><i>Areas covered</i>:</b> This article reviews the non-enzymatic functions of the ALDH superfamily. In addition, a search for additional non-catalytic ALDH records is undertaken. Our computational analyses reveal that there are currently 182 protein records (divided into 19 groups) that meet the criteria for dead enzymes.<b><i>Expert Opinion</i>:</b> Dead enzymes have the potential to exert biological actions through protein-protein interaction and allosteric modulation of the activity of an active enzyme. In addition, a dead enzyme may also influence availability of substrate for other active enzymes by sequestering substrate, and/or anchoring the substrate to a particular subcellular space. A large number of putatively non-catalytic ALDH proteins exist that warrant further study.
DOI: 10.6084/m9.figshare.1599794.v1
title: Data files from Chaudhuri, J. et al. Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci. Rep. 5, 17676; doi: 10.1038/srep17676 (2015).

description: Data files
DOI: 10.6084/m9.figshare.1599796.v2
title: BioSharing Posters

description: BioSharing Posters
DOI: 10.6084/m9.figshare.1599796.v1
title: BioSharing Posters

description: BioSharing Posters
DOI: 10.6084/m9.figshare.1599773
title: Efficacy of fulvestrant 500 mg in Japanese postmenopausal advanced/recurrent breast cancer patients and factors associated with prolonged time-to-treatment failure

description: <b><i>Objective</i>:</b> We aimed to confirm the efficacy of fulvestrant in Japanese postmenopausal advanced/recurrent breast cancer (ABC) patients, and investigate factors contributing to time-to-treatment failure (TTF) prolongation.<b><i>Research design and methods</i>:</b> This retrospective study included 194 ABC patients who received fulvestrant (500 mg) from January 2012 to December 2014.<b><i>Main outcome measures</i>:</b> TTF (efficacy measure), overall survival (OS), factors prolonging TTF and adverse events were evaluated.<b><i>Results</i>:</b> The median age was 65 (42 – 90) years. Overall, TTF was 5.48 months. In patients without prior chemotherapy (n = 59), OS was significantly longer (p = 0.0131) than in patients with prior chemotherapy (n = 135). There was no strong correlation between TTF with fulvestrant and other endocrine therapies, total duration of endocrine therapy and maximum duration of endocrine therapy. TTF was significantly longer in patients with less than two prior chemotherapy regimens (p = 0.0093), <i>de novo</i> metastatic disease (p = 0.0124) and without liver metastasis (p = 0.0024). We observed one case each of pulmonary infarction and psychiatric disorder.<b><i>Conclusions</i>:</b> Fulvestrant is effective for ABC patients and may show greater efficacy in patients with few prior chemotherapy regimens, <i>de novo</i> metastatic disease and absence of liver metastasis. Prior endocrine therapy duration might not be a predictive factor for fulvestrant TTF in heavily treated ABC patients.
DOI: 10.6084/m9.figshare.1599773.v2
title: Efficacy of fulvestrant 500 mg in Japanese postmenopausal advanced/recurrent breast cancer patients and factors associated with prolonged time-to-treatment failure

description: <b><i>Objective</i>:</b> We aimed to confirm the efficacy of fulvestrant in Japanese postmenopausal advanced/recurrent breast cancer (ABC) patients, and investigate factors contributing to time-to-treatment failure (TTF) prolongation.<b><i>Research design and methods</i>:</b> This retrospective study included 194 ABC patients who received fulvestrant (500 mg) from January 2012 to December 2014.<b><i>Main outcome measures</i>:</b> TTF (efficacy measure), overall survival (OS), factors prolonging TTF and adverse events were evaluated.<b><i>Results</i>:</b> The median age was 65 (42 – 90) years. Overall, TTF was 5.48 months. In patients without prior chemotherapy (n = 59), OS was significantly longer (p = 0.0131) than in patients with prior chemotherapy (n = 135). There was no strong correlation between TTF with fulvestrant and other endocrine therapies, total duration of endocrine therapy and maximum duration of endocrine therapy. TTF was significantly longer in patients with less than two prior chemotherapy regimens (p = 0.0093), <i>de novo</i> metastatic disease (p = 0.0124) and without liver metastasis (p = 0.0024). We observed one case each of pulmonary infarction and psychiatric disorder.<b><i>Conclusions</i>:</b> Fulvestrant is effective for ABC patients and may show greater efficacy in patients with few prior chemotherapy regimens, <i>de novo</i> metastatic disease and absence of liver metastasis. Prior endocrine therapy duration might not be a predictive factor for fulvestrant TTF in heavily treated ABC patients.
DOI: 10.6084/m9.figshare.1599771
title: Gaussian Job Archive for C6H15NO5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1599772
title: DataMatrixOrussidae

description: Data set used when describing two new species of Orussidae
DOI: 10.6084/m9.figshare.1599771.v1
title: Gaussian Job Archive for C6H15NO5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1599773.v1
title: Efficacy of fulvestrant 500 mg in Japanese postmenopausal advanced/recurrent breast cancer patients and factors associated with prolonged time-to-treatment failure

description: <b><i>Objective</i>:</b> We aimed to confirm the efficacy of fulvestrant in Japanese postmenopausal advanced/recurrent breast cancer (ABC) patients, and investigate factors contributing to time-to-treatment failure (TTF) prolongation.<b><i>Research design and methods</i>:</b> This retrospective study included 194 ABC patients who received fulvestrant (500 mg) from January 2012 to December 2014.<b><i>Main outcome measures</i>:</b> TTF (efficacy measure), overall survival (OS), factors prolonging TTF and adverse events were evaluated.<b><i>Results</i>:</b> The median age was 65 (42 – 90) years. Overall, TTF was 5.48 months. In patients without prior chemotherapy (n = 59), OS was significantly longer (p = 0.0131) than in patients with prior chemotherapy (n = 135). There was no strong correlation between TTF with fulvestrant and other endocrine therapies, total duration of endocrine therapy and maximum duration of endocrine therapy. TTF was significantly longer in patients with less than two prior chemotherapy regimens (p = 0.0093), <i>de novo</i> metastatic disease (p = 0.0124) and without liver metastasis (p = 0.0024). We observed one case each of pulmonary infarction and psychiatric disorder.<b><i>Conclusions</i>:</b> Fulvestrant is effective for ABC patients and may show greater efficacy in patients with few prior chemotherapy regimens, <i>de novo</i> metastatic disease and absence of liver metastasis. Prior endocrine therapy duration might not be a predictive factor for fulvestrant TTF in heavily treated ABC patients.
DOI: 10.6084/m9.figshare.1599770
title: DataMatrixOrussidae

description: complete morphological data set used when describing two new species of Australian Orussidae
DOI: 10.6084/m9.figshare.1599772.v1
title: DataMatrixOrussidae

description: Data set used when describing two new species of Orussidae
DOI: 10.6084/m9.figshare.1599770.v1
title: DataMatrixOrussidae

description: complete morphological data set used when describing two new species of Australian Orussidae
DOI: 10.6084/m9.figshare.1599763
title: LEMONS GUI win 64

description: LEMONS GUI for win64
DOI: 10.6084/m9.figshare.1599762
title: LEMONS GUI for win32

description: LEMONS GUI for win32
DOI: 10.6084/m9.figshare.1599763.v1
title: LEMONS GUI win 64

description: LEMONS GUI for win64
DOI: 10.6084/m9.figshare.1599761
title: LEMONS for LINUX

description: LEMONS is available on linux as a python script
DOI: 10.6084/m9.figshare.1599762.v1
title: LEMONS GUI for win32

description: LEMONS GUI for win32
DOI: 10.6084/m9.figshare.1599758
title: LEMONS ZIP archive for win64

description: LEMONS ZIP archive for win64
DOI: 10.6084/m9.figshare.1599758.v1
title: LEMONS ZIP archive for win64

description: LEMONS ZIP archive for win64
DOI: 10.6084/m9.figshare.1599757
title: LEMONS ZIP archive for win32

description: LEMONS ZIP archive for win32
DOI: 10.6084/m9.figshare.1599756
title: The Data used in Levin et al 2015 PLoS One

description: The Data used in Levin et al 2015 PLoS One
DOI: 10.6084/m9.figshare.1599757.v1
title: LEMONS ZIP archive for win32

description: LEMONS ZIP archive for win32
DOI: 10.6084/m9.figshare.1599756.v1
title: The Data used in Levin et al 2015 PLoS One

description: The Data used in Levin et al 2015 PLoS One
DOI: 10.6084/m9.figshare.1599751
title: Gaussian Job Archive for C6H14O5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1599751.v1
title: Gaussian Job Archive for C6H14O5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1599740
title: Gaussian Job Archive for C6H14O5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1599742
title: Gaussian Job Archive for C6H16ClNO5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1599740.v1
title: Gaussian Job Archive for C6H14O5

description: Archive of work produced using the resources of the Imperial College High Performance Computing Service.
DOI: 10.6084/m9.figshare.1598460
title: Editage certificate

description: English certificate from Editage
DOI: 10.6084/m9.figshare.1598321
title: Supporting Information

description: Annotation and Functional Assessment of Transporters in Aspergillus oryzae Metabolism
DOI: 10.6084/m9.figshare.1598460.v2
title: Editage certificate

description: English certificate from Editage
DOI: 10.6084/m9.figshare.1598321.v1
title: Supporting Information

description: Annotation and Functional Assessment of Transporters in Aspergillus oryzae Metabolism
DOI: 10.6084/m9.figshare.1598246
title: Enabling Interactivity on Displays of Multivariate Time Series and Longitudinal Data

description: Temporal data are information measured in the context of time. This contextual structure provides components that need to be explored to understand the data and that can form the basis of interactions applied to the plots. In multivariate time series, we expect to see temporal dependence, long term and seasonal trends, and cross-correlations. In longitudinal data, we also expect within and between subject dependence. Time series and longitudinal data, although analyzed differently, are often plotted using similar displays. We provide a taxonomy of interactions on plots that can enable exploring temporal components of these data types, and describe how to build these interactions using data transformations. Because temporal data are often accompanied other types of data we also describe how to link the temporal plots with other displays of data. The ideas are conceptualized into a data pipeline for temporal data and implemented into the R package cranvas. This package provides many different types of interactive graphics that can be used together to explore data or diagnose a model fit.
DOI: 10.6084/m9.figshare.1598460.v1
title: Editage

description: English certificate from Editage