cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11267165.v1
title: Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction

description: ABSTRACT The fixed drug eruption is a non-immediate hypersensitivity reaction to drug, characterized by recurrent erythematous or violaceous, rounded, well-defined border plaques, which always appear in the same location every time the culprit drug is administered. The usual practice is to avoid the drug involved and to use a structurally different drug. However, there are situations in which there is no safe and effective therapy. In such situations, desensitization is the only option. We describe the case of a patient who presented fixed eruption due to sulfamethoxazole-trimethoprim, who underwent successful desensitization, but required a repeat procedure twice due to relapse after inadvertent full-dose reintroduction. In non-immediate hypersensitivity reaction to drug, the indication is controversial and there is no technical standardization. Furthermore, the time at which such tolerance is lost after discontinuing the drug involved is unknown. In severe non-immediate reactions of types II and III, desensitization is contraindicated. The patient underwent desensitisation to sulfamethoxazole-trimethoprim three times − the first with recurrence of lesions and the second and third without manifestations, all concluded successfully and with no premedication.
DOI: 10.6084/m9.figshare.11267138
title: Computed tomography-measured body composition: correlation with postoperative morbidity and mortality in patients with gastroesophageal cancer

description: Abstract Objective: To determine whether preoperative anthropometric and computed tomography (CT) measurements of body composition can predict postoperative morbidity and mortality in patients with gastric or esophageal cancer. Materials and Methods: This was a retrospective study in which we reviewed the medical records and abdominal CT scans of patients with gastric or esophageal cancer who underwent surgery in 2015 at a cancer center. CT scans performed during routine preoperative evaluation were retrospectively assessed to measure the area of lean body mass at the level of the third lumbar vertebra, as well as the area of visceral and subcutaneous fat. Results: Seventy patients were included in the study. The mean age was 59.9 years (range, 33-82 years), and 47 patients (67.1%) were men. The mean postoperative follow-up period was 14.9 months. Neither postoperative morbidity nor postoperative mortality correlated significantly with gender, age, the type of primary tumor, the presence of comorbidities, smoking status, body mass index, nutritional status, or visceral fat area. The survival rate was higher for patients with normal lean body mass than for those with low lean body mass (hazard ratio = 0.116; 95% confidence interval: 0.015-0.906; p = 0.040). Conclusion: Our data suggest that lean body mass can be a relevant prognostic factor in patients with gastric or esophageal cancer, and that CT measurements should be included in the routine preoperative evaluation, because it may provide information that aids nutritional and clinical care for these patients.
DOI: 10.6084/m9.figshare.11267144
title: Proteins and Peptides at the Interfaces of Nanostructures

description: Abstract: The present review focuses on the proteins and peptides at the interfaces of nanostructured metals and semiconductors as a result of their use in synthesis in-situ and functionalization of nanostructures. We start the review with an introduction about the peculiar properties of nanostructured materials and their applications. In the following, the chemical and structural properties of peptides and proteins that allow their use as reducing, stabilizing, and functionalization agents are discussed. Proteins and peptides have not only the chemical groups for the metal ion reducing but also provide templates for directing the crystalline growing of nanostructures to the desired shapes and sizes. Proteins and peptides are also used mainly for the stabilization and functionalization of a diversity of nanostructured materials providing properties such as biocompatibility, plasmon-enhanced catalysis, sensing, micro/nanomotors, spin filters, and others. Nanostructured materials of metal oxides have mainly been functionalized with proteins and peptides to gain specific properties such as light harvesting and spin filters. Herein, we described the synthesis and functionalization of some types of nanostructured materials by using peptides and proteins. In the last part of the review, it is discussed the perspectives and challenges for the use of proteins and peptides in Nanotechnology.
DOI: 10.6084/m9.figshare.11267147
title: Weathering Resistance of Waterborne Polyurethane Coatings Reinforced with Silica from Rice Husk Ash

description: Abstract: Waterborne polyurethanes (WPUs) are interesting materials for coatings when compared to solvent-based polyurethanes, once that reducing the concentration of volatile organic compounds that are harmful for human health and the environment. However, the WPU has low weathering resistance. In order to improve this behavior among others properties, inorganic fillers has been added in these systems. SiO2 particles from various sources, mainly, from agro-industrial waste, as rice husk has attracted the scientific and technological interest. In this study, the accelerated weathering essay was performed in waterborne polyurethane (WPU)/ silica (from rice husk ash) composites in order to evaluate the thermal and physical changes in these materials. These composites were prepared by two distinct methods: in situ polymerization and blending method. The highest resistance to thermal degradation and to accelerated weathering was reached with WPU/silica composites obtained by blending method due the interactions between SiO2 particles and the polymer matrices. Blending method for preparation WPU/silica composites proved to be a simpler and faster method, with no drawback for large scale application.
DOI: 10.6084/m9.figshare.11267129
title: Efeito da Formação Docente Sobre Proficiência no Início do Ensino Fundamental

description: Abstract The effects of teacher education on public school students’ performance are assessed through a value-added model that deals with endogeneity. No statistically significant effects of higher education were found on students’ proficiency. However, students who had teachers with major in Mathematics showed an average gain in proficiency in Mathematics of about 4 points on the SAEB scale (7% of ��) higher than students who had teachers without higher education. On the other hand, the effect of teachers who have major in Languages was lower, with an average proficiency gain in Mathematics of about 14 points (2,6% of ��).
DOI: 10.6084/m9.figshare.11267138.v1
title: Computed tomography-measured body composition: correlation with postoperative morbidity and mortality in patients with gastroesophageal cancer

description: Abstract Objective: To determine whether preoperative anthropometric and computed tomography (CT) measurements of body composition can predict postoperative morbidity and mortality in patients with gastric or esophageal cancer. Materials and Methods: This was a retrospective study in which we reviewed the medical records and abdominal CT scans of patients with gastric or esophageal cancer who underwent surgery in 2015 at a cancer center. CT scans performed during routine preoperative evaluation were retrospectively assessed to measure the area of lean body mass at the level of the third lumbar vertebra, as well as the area of visceral and subcutaneous fat. Results: Seventy patients were included in the study. The mean age was 59.9 years (range, 33-82 years), and 47 patients (67.1%) were men. The mean postoperative follow-up period was 14.9 months. Neither postoperative morbidity nor postoperative mortality correlated significantly with gender, age, the type of primary tumor, the presence of comorbidities, smoking status, body mass index, nutritional status, or visceral fat area. The survival rate was higher for patients with normal lean body mass than for those with low lean body mass (hazard ratio = 0.116; 95% confidence interval: 0.015-0.906; p = 0.040). Conclusion: Our data suggest that lean body mass can be a relevant prognostic factor in patients with gastric or esophageal cancer, and that CT measurements should be included in the routine preoperative evaluation, because it may provide information that aids nutritional and clinical care for these patients.
DOI: 10.6084/m9.figshare.11267144.v1
title: Proteins and Peptides at the Interfaces of Nanostructures

description: Abstract: The present review focuses on the proteins and peptides at the interfaces of nanostructured metals and semiconductors as a result of their use in synthesis in-situ and functionalization of nanostructures. We start the review with an introduction about the peculiar properties of nanostructured materials and their applications. In the following, the chemical and structural properties of peptides and proteins that allow their use as reducing, stabilizing, and functionalization agents are discussed. Proteins and peptides have not only the chemical groups for the metal ion reducing but also provide templates for directing the crystalline growing of nanostructures to the desired shapes and sizes. Proteins and peptides are also used mainly for the stabilization and functionalization of a diversity of nanostructured materials providing properties such as biocompatibility, plasmon-enhanced catalysis, sensing, micro/nanomotors, spin filters, and others. Nanostructured materials of metal oxides have mainly been functionalized with proteins and peptides to gain specific properties such as light harvesting and spin filters. Herein, we described the synthesis and functionalization of some types of nanostructured materials by using peptides and proteins. In the last part of the review, it is discussed the perspectives and challenges for the use of proteins and peptides in Nanotechnology.
DOI: 10.6084/m9.figshare.11267147.v1
title: Weathering Resistance of Waterborne Polyurethane Coatings Reinforced with Silica from Rice Husk Ash

description: Abstract: Waterborne polyurethanes (WPUs) are interesting materials for coatings when compared to solvent-based polyurethanes, once that reducing the concentration of volatile organic compounds that are harmful for human health and the environment. However, the WPU has low weathering resistance. In order to improve this behavior among others properties, inorganic fillers has been added in these systems. SiO2 particles from various sources, mainly, from agro-industrial waste, as rice husk has attracted the scientific and technological interest. In this study, the accelerated weathering essay was performed in waterborne polyurethane (WPU)/ silica (from rice husk ash) composites in order to evaluate the thermal and physical changes in these materials. These composites were prepared by two distinct methods: in situ polymerization and blending method. The highest resistance to thermal degradation and to accelerated weathering was reached with WPU/silica composites obtained by blending method due the interactions between SiO2 particles and the polymer matrices. Blending method for preparation WPU/silica composites proved to be a simpler and faster method, with no drawback for large scale application.
DOI: 10.6084/m9.figshare.11267114
title: Determining the pathogenicity of CFTR missense variants: Multiple comparisons of in silico predictors and variant annotation databases

description: Abstract Pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for cystic fibrosis (CF), the commonest monogenic autosomal recessive disease, and CFTR-related disorders in infants and youth. Diagnosis of such diseases relies on clinical, functional, and molecular studies. To date, over 2,000 variants have been described on CFTR (~40% missense). Since few of them have confirmed pathogenicity, in silico analysis could help molecular diagnosis and genetic counseling. Here, the pathogenicity of 779 CFTR missense variants was predicted by consensus predictor PredictSNP and compared to annotations on CFTR2 and ClinVar. Sensitivity and specificity analysis was divided into modeling and validation phases using just variants annotated on CFTR2 and/or ClinVar that were not in the validation datasets of the analyzed predictors. After validation phase, MAPP and PhDSNP achieved maximum specificity but low sensitivity. Otherwise, SNAP had maximum sensitivity but null specificity. PredictSNP, PolyPhen-1, PolyPhen-2, SIFT, nsSNPAnalyzer had either low sensitivity or specificity, or both. Results showed that most predictors were not reliable when analyzing CFTR missense variants, ratifying the importance of clinical information when asserting the pathogenicity of CFTR missense variants. Our results should contribute to clarify decision making when classifying the pathogenicity of CFTR missense variants.
DOI: 10.6084/m9.figshare.11267117
title: Special Education in Teacher Training: a Study on Undergraduate Courses in Pedagogy

description: ABSTRACT This text presents results of an investigation on Special Education (SE) in the initial formation of teachers of Early Childhood Education and initial grades of Elementary Education, in the Pedagogy degree courses offered by the Federal Universities of Minas Gerais, Brazil. It is a documentary and bibliographic analysis using as main sources the Legal Guidelines and the Courses Pedagogical Master Plans (PMP). In 2018, ten active courses were identified, in the face-to-face modality, at the Universities: UNIFAL, UFJF, UFLA, UFMG, UFOP, UFSJ, UFU, FACIP / UFU, UFV and UFVJM. It was found that the PMP met the National Guidelines for Higher Education Courses, approved in 2006. All courses offered curricular components related to SE, but with reduced course hours (CH) compared to the total CH. The study of "Sign Language" was included in all PMP in compliance with Decree 5,626/2005. The comparative analysis of the documents corroborates previous research, such as: Deimling (2013), Omote and Marinho (2017), Pedroso, Campos and Duarte (2013). SE occupies a restricted space in the curricula, in the objectives, in the profile of the graduate, in the CH, in the organization of the formative trajectories, which represents a gap in the initial formation. These evidences indicate the necessary expansion of SE space in Pedagogy Courses and the continuous training of teachers in this area in order to make inclusive education real.
DOI: 10.6084/m9.figshare.11267129.v1
title: Efeito da Formação Docente Sobre Proficiência no Início do Ensino Fundamental

description: Abstract The effects of teacher education on public school students’ performance are assessed through a value-added model that deals with endogeneity. No statistically significant effects of higher education were found on students’ proficiency. However, students who had teachers with major in Mathematics showed an average gain in proficiency in Mathematics of about 4 points on the SAEB scale (7% of ��) higher than students who had teachers without higher education. On the other hand, the effect of teachers who have major in Languages was lower, with an average proficiency gain in Mathematics of about 14 points (2,6% of ��).
DOI: 10.6084/m9.figshare.11267111
title: Forces in the accelerated reference system of a pendulum: theoretical study and experimental results

description: Abstract In this work we initially lead a theoretical discussion about the forces acting on a physical pendulum oscillating without friction in an accelerated reference system. Such discussion allows us the statement that if an accelerometer is fixed on the center of oscillation of the pendulum, it will register an oscillating value in the radial axis and a null value in the tangential axis. To illustrate this proposition, we will present two simple situation for verification and then we inquire two instigating questions: a)What will happen to the air bubble of a mason level, if we position the same in the tangential direction while we cradle in a swing of a square? b) If we put a small sphere on oscillating swing, will the sphere be in rest during the oscillation? The answers for this counter intuitive questions are that both, the air bubble and small sphere, will stay in rest in relation to the swing if they are positioned on the center of oscillation of the pendulum. In order to elucidate the above questions, we designed an experimental apparatus composed of a physical pendulum, in which we attached an Arduino microcontroller board, an accelerometer sensor and a Bluetooth module.
DOI: 10.6084/m9.figshare.11267117.v1
title: Special Education in Teacher Training: a Study on Undergraduate Courses in Pedagogy

description: ABSTRACT This text presents results of an investigation on Special Education (SE) in the initial formation of teachers of Early Childhood Education and initial grades of Elementary Education, in the Pedagogy degree courses offered by the Federal Universities of Minas Gerais, Brazil. It is a documentary and bibliographic analysis using as main sources the Legal Guidelines and the Courses Pedagogical Master Plans (PMP). In 2018, ten active courses were identified, in the face-to-face modality, at the Universities: UNIFAL, UFJF, UFLA, UFMG, UFOP, UFSJ, UFU, FACIP / UFU, UFV and UFVJM. It was found that the PMP met the National Guidelines for Higher Education Courses, approved in 2006. All courses offered curricular components related to SE, but with reduced course hours (CH) compared to the total CH. The study of "Sign Language" was included in all PMP in compliance with Decree 5,626/2005. The comparative analysis of the documents corroborates previous research, such as: Deimling (2013), Omote and Marinho (2017), Pedroso, Campos and Duarte (2013). SE occupies a restricted space in the curricula, in the objectives, in the profile of the graduate, in the CH, in the organization of the formative trajectories, which represents a gap in the initial formation. These evidences indicate the necessary expansion of SE space in Pedagogy Courses and the continuous training of teachers in this area in order to make inclusive education real.
DOI: 10.6084/m9.figshare.11267090
title: Relationship between right atrium area and right ventricular ejection fraction on magnetic resonance imaging: comparison with other prognostic markers in patients with pulmonary arterial hypertension

description: Abstract Objective: To compare the right atrium (RA) area and right ventricular ejection fraction (RVEF) with other known prognostic markers in patients with pulmonary arterial hypertension (PAH). Materials and Methods: This was a retrospective study of 74 patients diagnosed with PAH by right heart catheterization at a referral center between January 2018 and May 2018. All of the patients underwent cardiac magnetic resonance imaging (MRI) within 3 months of the right heart catheterization (RHC), as well as undergoing echocardiography, a 6-minute walk test, and determination of the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) within a month of the RHC. We attempted to determine whether the cardiac MRI-derived RA area correlated with ions between RVEF and RA area measured by that determined by echocardiography, as well as whether the cardiac MRI-derived RA area and RVEF correlated with the 6-minute walk distance and NT-proBNP level. Results: The MRI-derived RA area demonstrated a weak correlation with the pulmonary vascular resistance measured by RHC (r = 0.268; p = 0.055) and a moderate correlation with the NT-proBNP (r = 0.429; p = 0.003). All correlations between clinical characteristics and the RVEF were statistically significant. In the univariate linear analysis, the RVEF showed stronger correlations with the clinical characteristics than did the RA area. Conclusion: In patients with PAH, cardiac MRI-derived RVEF appears to correlate more strongly with other prognostic factors than does RA area.
DOI: 10.6084/m9.figshare.11267102
title: Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide

description: Abstract This study evaluated the genotoxicity, mutagenicity, antigenotoxicity, and antimutagenicity effects on biochemical parameters of oxidative stress of the Spondias dulcis bark ethanolic extract on mice. The extract was evaluated in the doses of 500, 1000, and 1500 mg/kg bw via gavage. To evaluate the protective effects of the extract, benzo[a]pyrene (B[a]P) and cyclophosphamide (CP) were chosen as DNA damage inducers. Genotoxicity and antigenotoxicity were evaluated by the comet assay. Cytotoxicity, mutagenicity, and antimutagenicity were evaluated by the micronucleus test in bone marrow and peripheral blood. The biochemical parameters of oxidative stress were evaluated by the quantification of catalase activity (CAT) and reduced glutathione (GSH) in total blood, liver and kidney, and malondialdehyde (MDA), in liver and kidney. No genotoxic, cytotoxic, or mutagenic effect was found on mice exposed to the extract. The extract depleted the number of damaged nucleoids in total blood and the number of micronucleus (MN) in both cell types. The extract was able to increase CAT activity and GSH levels and decrease MDA levels after treatment with B[a]P and CP. The results indicate that the S. dulcis extract has potential to be used as preventive compound against DNA damage caused by CP and B[a]P.
DOI: 10.6084/m9.figshare.11267108
title: The Employee Is Always Right: Employee Satisfaction and Corporate Performance in Brazil

description: Abstract I investigate the effect of employee satisfaction on corporate performance based on an extensive dataset of 114,004 online reviews of Brazil’s 1,000 largest listed and unlisted firms from 2013 to 2018 posted at a local subsidiary of Glassdoor. I find that overall employee satisfaction is positively associated with firm performance and that this relationship is likely to be economically relevant. Among the four dimensions of employee well-being, the link with performance is most evident for the dimension on culture, followed by career opportunities. On the other hand, the dimension on compensation and benefits was the least connected with firm performance. Taken together, these results support the view that intrinsic motivators are more relevant for superior performance than extrinsic ones popularized by the carrot and stick approach to management. I also find that the influence of employee satisfaction on performance is likely to be asymmetrical, in the sense that workplaces characterized by low satisfaction among workers are more likely to lead to poor performance than best-in-class companies are likely to produce superior performance. To my knowledge, this is the first paper to document an asymmetrical link between firm value and employee satisfaction, as well the first one to investigate this issue in an emerging economy using online reviews.