cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26927365
title: LC-MS/MS method for simultaneous Doxorubicin and Baicalein estimation: formulation and pharmacokinetic applications

description: <b>Aim & objective:</b> Combinatorial delivery of Doxorubicin (DOX) and Baicalein (BAC) has a potential to improve breast cancer treatment by mitigating the cardiotoxicity induced by DOX. The nanoformulation has been optimized and subjected to pharmacokinetic studies using LC-MS/MS. <b>Materials & methods:</b> Nanoformulation bearing DOX and BAC was optimized using quality by design approach and method validation was done following USFDA guidelines. <b>Results:</b> The particle size, PDI and zeta potential of developed nanoformulation were 162.56 ± 2.21 nm, 0.102 ± 0.03 and -16.5 ± 1.21 mV, respectively. DOX-BAC-SNEDDs had a higher AUC<sub>0-t</sub> values of 6128.84 ± 68.71 and 5896.62 ± 99.31 ng/mL/h as compared with DOX-BAC suspension. <b>Conclusion:</b> These findings hold promise for advancing breast cancer treatment and facilitating therapeutic drug monitoring. Mechanistic scheme of DOX-BAC-loaded SNEDDs development and its characterization using LC-MS/MS. Baicalein (BAC) lowers cardiac oxidative stress which reduces the cardiotoxicity associated with Doxorubicin (DOX). Combination therapies enhance efficacy by targeting multiple disease pathways simultaneously, improving treatment outcomes and reducing drug resistance. The Quality by Design approach was employed in optimizing the self-nanoemulsifying drug delivery system. Currently, there is no published bioanalytical method utilizing either LC-MS/MS or HPLC for simultaneous determination of both DOX and BAC. Both DOX and BAC were resolved using mobile phase of 0.1% v/v FA in milli-Q water and 0.1% v/v FA in MeOH (20:80%v/v) with a flow rate of 0.3 mL/min. USFDA guidelines were employed for assessing several validation factors, including recovery, stability studies, specificity, accuracy and percent relative standard deviation. The co-estimation of DOX and BAC in rat plasma in order to generate an oral P.K. profile was successfully demonstrated using the developed LC-MS/MS.
DOI: 10.6084/m9.figshare.26927365.v1
title: LC-MS/MS method for simultaneous Doxorubicin and Baicalein estimation: formulation and pharmacokinetic applications

description: <b>Aim & objective:</b> Combinatorial delivery of Doxorubicin (DOX) and Baicalein (BAC) has a potential to improve breast cancer treatment by mitigating the cardiotoxicity induced by DOX. The nanoformulation has been optimized and subjected to pharmacokinetic studies using LC-MS/MS. <b>Materials & methods:</b> Nanoformulation bearing DOX and BAC was optimized using quality by design approach and method validation was done following USFDA guidelines. <b>Results:</b> The particle size, PDI and zeta potential of developed nanoformulation were 162.56 ± 2.21 nm, 0.102 ± 0.03 and -16.5 ± 1.21 mV, respectively. DOX-BAC-SNEDDs had a higher AUC<sub>0-t</sub> values of 6128.84 ± 68.71 and 5896.62 ± 99.31 ng/mL/h as compared with DOX-BAC suspension. <b>Conclusion:</b> These findings hold promise for advancing breast cancer treatment and facilitating therapeutic drug monitoring. Mechanistic scheme of DOX-BAC-loaded SNEDDs development and its characterization using LC-MS/MS. Baicalein (BAC) lowers cardiac oxidative stress which reduces the cardiotoxicity associated with Doxorubicin (DOX). Combination therapies enhance efficacy by targeting multiple disease pathways simultaneously, improving treatment outcomes and reducing drug resistance. The Quality by Design approach was employed in optimizing the self-nanoemulsifying drug delivery system. Currently, there is no published bioanalytical method utilizing either LC-MS/MS or HPLC for simultaneous determination of both DOX and BAC. Both DOX and BAC were resolved using mobile phase of 0.1% v/v FA in milli-Q water and 0.1% v/v FA in MeOH (20:80%v/v) with a flow rate of 0.3 mL/min. USFDA guidelines were employed for assessing several validation factors, including recovery, stability studies, specificity, accuracy and percent relative standard deviation. The co-estimation of DOX and BAC in rat plasma in order to generate an oral P.K. profile was successfully demonstrated using the developed LC-MS/MS.
DOI: 10.6084/m9.figshare.25365672
title: Robust Multivariate Functional Control Chart

description: In modern Industry 4.0 applications, a huge amount of data is acquired during manufacturing processes and is often contaminated with outliers, which can seriously reduce the performance of control charting procedures, especially in complex and high-dimensional settings. In the context of profile monitoring, we propose a new framework that is referred to as robust multivariate functional control chart (RoMFCC) to monitor a multivariate functional quality characteristic while being robust to both functional casewise and componentwise outliers. In the former case, observations of the quality characteristic are contaminated in all functional variables or components, while, in the latter, the contamination affects one or more components independently. The RoMFCC relies on (I) a functional filter to identify componentwise outliers to be replaced by missing components; (II) a robust multivariate functional data imputation method; (III) a casewise robust dimensionality reduction; (IV) a monitoring strategy for the quality characteristic. Through a Monte Carlo simulation study, the RoMFCC is compared with competing schemes that have already appeared in the literature. A case study is finally presented where the proposed framework is used to monitor a resistance spot welding process in the automotive industry. RoMFCC is implemented in the R package funcharts, available online on CRAN.
DOI: 10.6084/m9.figshare.25365672.v1
title: Robust Multivariate Functional Control Chart

description: In modern Industry 4.0 applications, a huge amount of data is acquired during manufacturing processes and is often contaminated with outliers, which can seriously reduce the performance of control charting procedures, especially in complex and high-dimensional settings. In the context of profile monitoring, we propose a new framework that is referred to as robust multivariate functional control chart (RoMFCC) to monitor a multivariate functional quality characteristic while being robust to both functional casewise and componentwise outliers. In the former case, observations of the quality characteristic are contaminated in all functional variables or components, while, in the latter, the contamination affects one or more components independently. The RoMFCC relies on (I) a functional filter to identify componentwise outliers to be replaced by missing components; (II) a robust multivariate functional data imputation method; (III) a casewise robust dimensionality reduction; (IV) a monitoring strategy for the quality characteristic. Through a Monte Carlo simulation study, the RoMFCC is compared with competing schemes that have already appeared in the literature. A case study is finally presented where the proposed framework is used to monitor a resistance spot welding process in the automotive industry. RoMFCC is implemented in the R package funcharts, available online on CRAN.
DOI: 10.15468/dl.m6uw66
title: Occurrence Download

description: A dataset containing 179 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Abies pinsapo Boiss.)",
 "Country is one of (Spain)",
 "BasisOfRecord is one of (Specimen, Literature Occurrence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 179 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004534-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.76qsgb
title: Occurrence Download

description: A dataset containing 811 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Coeligena orina Wetmore, 1953"
 ]
}

 The dataset includes 811 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004536-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w8ev6b
title: Occurrence Download

description: A dataset containing 314758 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is one of (Elanus leucurus (Vieillot, 1818))",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence)",
 "Year is greater than or equal to 1901",
 "Year is less than or equal to 2019",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 314758 records from 108 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004486-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5gxek2
title: Occurrence Download

description: A dataset containing 535027 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Portugal",
 "Geometry POLYGON((-8.84919 40.45319,-8.47152 40.45319,-8.47152 40.88307,-8.84919 40.88307,-8.84919 40.45319))",
 "HasCoordinate is true",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 535027 records from 189 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004490-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c33n8t
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-37.07911 29.94289,-4.98636 29.94289,-4.98636 48.18563,-37.07911 48.18563,-37.07911 29.94289))",
 "TaxonKey is Photonectes dinema Regan & Trewavas, 1930"
 ]
}

 The dataset includes 9 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004537-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.he9yhq
title: Occurrence Download

description: A dataset containing 2627340 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Caryophyllales)",
 "HasCoordinate is true",
 "BasisOfRecord is Specimen"
 ]
}

 The dataset includes 2627340 records from 1352 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004500-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ckr14i
title: Occurrence Download

description: A dataset containing 162 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Scrophularia alata A.Gray"
 ]
}

 The dataset includes 162 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004599-190813142620410/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pj7r45
title: Occurrence Download

description: A dataset containing 197 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acacia subternata F.Muell."
 ]
}

 The dataset includes 197 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007321-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.a0tdzr
title: Occurrence Download

description: A dataset containing 2012 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Columba fasciata Say, 1822",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 2012 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041930-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bbwdov
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cynodon dactylon var. septentrionalis (Asch. & Graebn.) Ravarut"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004600-160509122628363/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.texjdh
title: Occurrence Download

description: A dataset containing 1894 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acacia aulacocarpa A.Cunn. ex Benth."
 ]
}

 The dataset includes 1894 records from 60 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007283-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3cqow3
title: Occurrence Download

description: A dataset containing 2837310 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Plantae",
 "Continent is North America",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 2837310 records from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041931-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mzjxqm
title: Occurrence Download

description: A dataset containing 105 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Quercus guyavifolia H.Lév."
 ]
}

 The dataset includes 105 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004600-160623103540712/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gwhy5d
title: Occurrence Download

description: A dataset containing 42 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acacia levata R.S.Cowan & Maslin"
 ]
}

 The dataset includes 42 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007296-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.itf2op
title: Occurrence Download

description: A dataset containing 2432 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Norway",
 "Country is Sweden",
 "Country is Finland",
 "Country is Russian Federation",
 "Country is Denmark",
 "Country is Belarus",
 "Country is Lithuania",
 "Country is Iceland",
 "Country is Latvia"
 ]
 },
 {
 "or" : [
 "EstablishmentMeans is INVASIVE",
 "EstablishmentMeans is MANAGED",
 "EstablishmentMeans is INTRODUCED",
 "EstablishmentMeans is NATURALISED",
 "EstablishmentMeans is UNCERTAIN"
 ]
 }
 ]
}

 The dataset includes 2432 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041934-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mtnh9q
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Microplophorus castaneus Blanchard, 1851"
 ]
}

 The dataset includes 5 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004600-170826194755519/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.htt4vq
title: Occurrence Download

description: A dataset containing 11 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lepanthes mirador Luer & Hirtz"
 ]
}

 The dataset includes 11 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0170179-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.baghs5
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acacia subrigida Maslin"
 ]
}

 The dataset includes 41 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007317-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ch9n34
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Maxillaria foldatsiana Carnevali & I.Ramírez"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0170181-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tjs4qh
title: Occurrence Download

description: A dataset containing 558 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lysiphyllum hookeri (F.Muell.) Pedley"
 ]
}

 The dataset includes 558 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0170180-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.sd8anx
title: Occurrence Download

description: A dataset containing 308 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Spain",
 "Issue is one of (Geodetic datum assumed WGS84, Coordinate precision invalid)",
 "OccurrenceStatus is Present",
 "TaxonKey is Olea europaea subsp. europaea"
 ]
}

 The dataset includes 308 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025759-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.lstqdc
title: Occurrence Download

description: A dataset containing 7595 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Pharomachrus mocinno La Llave, 1832",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 7595 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004603-171113114016250/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nhpb3w
title: Occurrence Download

description: A dataset containing 1269 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Plethodon cheoah Highton & Peabody, 2000)"
 ]
}

 The dataset includes 1269 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007297-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h3moeg
title: Occurrence Download

description: A dataset containing 356 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Mexico",
 "Geometry POLYGON((-151.62157 -34.73402,14.62157 -34.73402,14.62157 31.73402,-151.62157 31.73402,-151.62157 -34.73402))",
 "HasCoordinate is true",
 "TaxonKey is Trachops cirrhosus (Spix, 1823)",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 356 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004604-190918142434337/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.o2y1w2
title: Occurrence Download

description: A dataset containing 25 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Solanum viarum Dunal",
 {
 "or" : [
 "Country is Mexico",
 "Country is Belgium",
 "Country is Australia",
 "Country is India",
 "Country is South Africa"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 25 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041940-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pj2qy2
title: Occurrence Download

description: A dataset containing 455 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Acacia subtilinervis F.Muell."
 ]
}

 The dataset includes 455 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007326-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kvskf4
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2015",
 "Month is greater than or equal to January",
 "Country is India",
 "TaxonKey is Blattodea"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001762-150721130643939/datasets/export for details.
DOI: 10.15468/dl.qsol8b
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ailuropoda melanoleuca (David, 1869)",
 "DatasetKey is NMNH occurrence DwC-A"
 ]
}

 The dataset includes 28 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004605-150316153013904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c2vkw4
title: Occurrence Download

description: A dataset containing 709 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Astragalus tibetanus Benth. ex Bunge"
 ]
}

 The dataset includes 709 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037881-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zefutr
title: Occurrence Download

description: A dataset containing 71735 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Sus scrofa Linnaeus, 1758"
 ]
}

 The dataset includes 71735 records from 322 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0041949-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.63eh8r
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Limonium bahamense (Griseb.) Britton"
 ]
}

 The dataset includes 71 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0170182-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.