cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6073/pasta/7b27d265a744ffe52c75cb89db985cef
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 1999-11-25
DOI: 10.6073/pasta/b7acb9225a8d298e6f96efe2b3acbb9f
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-03-20
DOI: 10.6073/pasta/c6e2cd89acb935f028d6b88b31a40479
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-04-05
DOI: 10.6073/pasta/ddfb7883a8891fa1ed3d0d19779e45e2
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-05-07
DOI: 10.6073/pasta/f14b40846a1dd4ee2ef69de2f5fe2ad9
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-04-21
DOI: 10.6073/pasta/fbe98e76f09f0718f2bcdceafa3c74d2
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-02-17
DOI: 10.14457/kku.the.2003.70
title: การประยุกต์ใช้แนวคิดเทคนิค AIC ในการส่งเสริมการดูแลตนเองของผู้ป่วย ความดันโลหิตสูงชนิดไม่ทราบสาเหตุ : กรณีศึกษา 3 หมู่บ้าน ในตำบลเขารวก อำเภอลำสนธิ จังหวัดลพบุรี /
DOI: 10.14457/kku.the.2004.58
title: การประยุกต์ใช้เทคโนโลยีสะอาดสำหรับงานโรงพยาบาล กรณีศึกษา : โรงซักฟอกโรงพยาบาลส่งเสริมสุขภาพ ศูนย์อนามัยที่ 6 /
DOI: 10.14457/kku.the.2004.59
title: การประยุกต์ใช้แบบจำลอง INFOWORKS RS สำหรับการคำนวณการหลากในลำน้ำของลุ่มน้ำชี /
DOI: 10.14457/kku.the.2005.44
title: การประยุกต์ใช้เทคนิคชีววิทยาระดับโมเลกุล เพื่อการตรวจสอบลายพิมพ์ดีเอ็นเอ ของสายพันธุ์ถั่วลิสง (Arachis hypogaea L.) ที่มีระดับความต้านทานต่อโรคยอดไหม้แตกต่างกัน /
DOI: 10.14457/kku.the.2005.45
title: การประยุกต์ใช้แรงสนับสนุนทางสังคม ในการพัฒนาพฤติกรรมป้องกันอุบัติเหตุของพนักงาน โรงงานทออวนเดชาพานิช ตำบลสำราญ อำเภอเมือง จังหวัดขอนแก่น /
DOI: 10.14457/kku.the.2006.50
title: การประยุกต์ใช้เทคโนโลยีสะอาด เพื่อลดปริมาณการใช้น้ำในโรงพยาบาลกาฬสินธุ์ /
DOI: 10.14457/kku.the.2008.52
title: การประยุกต์ใช้หลักเศรษฐกิจพอเพียงกับธุรกิจค้าปลีกในจังหวัดอุดรธานี /
DOI: 10.14457/kku.the.2008.53
title: การประยุกต์ใช้เศรษฐกิจพอเพียงกับธุรกิจค้าปลีกในจังหวัดหนองคาย /
DOI: 10.14457/kku.the.2009.82
title: การประยุกต์ใช้แบบจำลองคณิตศาสตร์ในการทำนายคุณภาพน้ำในแม่น้ำพอง /
DOI: 10.14457/ku.the.2009.755
title: ความสามารถในการแข่งขันระหว่างประเทศของประเทศไทย ที่มีผลจากการเปลี่ยนแปลงเทคโนโลยีจากการลงทุนทางตรงระหว่างประเทศ /
DOI: 10.14457/ku.the.2009.756
title: ความสำคัญของแร่ธาตุหลัก 5 ชนิด (Na, K, Ca, Mg และ C1) สำหรับการอนุบาลกุ้งก้ามกราม (Macrobrachium rosenbergii de Man)
DOI: 10.14457/ku.the.2011.531
title: ความสามารถในการแข่งขันอาหารทะเลแช่เย็นแช่แข็งของประเทศไทยในตลาดต่างประเทศที่สำคัญ
DOI: 10.6073/pasta/943d1ab2bae4e78ca18c5661fae5b4b0
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 2008-04-23
DOI: 10.6073/pasta/a76d482a866c06a16bd2c27497f4d63c
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 1990-05-08
DOI: 10.6073/pasta/b8814c55759a5f50d267b1dca18e015e
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-06-08
DOI: 10.6073/pasta/ba7cbd563952e6d358b01f5c43085e11
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 2008-02-03
DOI: 10.6073/pasta/c2c5936d857e03bb2dae8ea17e9c6611
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-05-23
DOI: 10.6073/pasta/cf3744b2fa21e6a8d3edde0ba7392ee6
title: Experimental Understory Food Web data in the El Verde area of the Luquillo Experimental Forest
DOI: 10.6073/pasta/d84fce166673eec5b85b055da8ca2cd2
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-06-24
DOI: 10.6073/pasta/dd70dfeb90477082b58aee699808c916
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 1990-04-06
DOI: 10.6073/pasta/e698c0823100f022ce28b0ce9bbeaa1b
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 1990-01-16
DOI: 10.14457/ku.the.2006.1036
title: ความสำเร็จของการกำกับดูแลที่ดีในรัฐวิสาหกิจ : ประสบการณ์จากการประปาส่วนภูมิภาค /
DOI: 10.14457/ku.the.2006.1037
title: ความหลากกลายของชนิดชันโรง (Apidae : Trigona spp. และ Hypotrigona spp.) และพฤติกรรมการเก็บยางไม้จากธรรมชาติ ในโครงการทองผาภูมิ 72 พรรษามหาราช อำเภอทองผาภูมิ จังหวัดกาญจนบุรี /
DOI: 10.14457/ku.the.2007.763
title: ความหลากชนิดของมดในมหาวิทยาลัยเกษตรศาสตร์ วิทยาเขตศรีราชา จังหวัดชลบุรี /
DOI: 10.14457/ku.the.2007.764
title: ความหลากชนิดและการประเมินถิ่นที่อยู่ที่เหมาะสมของไม้สกุลมะเดื่อ ในสถานีวิจัยลุ่มน้ำแม่กลอง อำเภอทองผาภูมิ จังหวัดกาญจนบุรี
DOI: 10.14457/ku.the.2008.568
title: ความสำเร็จจากการมีส่วนร่วมของประชาชน ในการอนุรักษ์พื้นที่ป่าห้วยไถบ้านดอนมูล ตำบลบ้านปวง อำเภอทุ่งหัวช้าง จังหวัดลำพูน /
DOI: 10.14457/ku.the.2008.569
title: ความหลากชนิดของปลาในลุ่มแม่น้ำน่าน [ระบบแม่น้ำเจ้าพระยา] ในเขตจังหวัดน่าน /
DOI: 10.14457/ku.the.2008.570
title: ความหลากชนิดของสัตว์ ในแหล่งดำน้ำเกาะสาก จังหวัดชลบุรี /
DOI: 10.14457/ku.the.2009.757
title: ความหลากชนิดของสัตว์เลื้อยคลานในพื้นที่ป่าเขาหินปูนและศาสนสถาน ตำบลเขาวง อำเภอพระพุทธบาท จังหวัดสระบุรี /
DOI: 10.14457/ku.the.2010.620
title: ความหลากชนิด ลักษณะกะโหลกและฟันของสัตว์เลี้ยงลูกด้วยนมวงศ์หนูในโครงการพัฒนาดอยตุง (พื้นที่ทรงงาน) อันเนื่องมาจากพระราชดำริจังหวัดเชียงราย
DOI: 10.6073/pasta/013e210e59ac2604cdb051e5c29cce01
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 2003-08-05
DOI: 10.6073/pasta/109da912145e3945b2af5d6d880de9dd
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 2003-07-04
DOI: 10.6073/pasta/1ff83b74730ae3620f01d65015a39459
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-09-28
DOI: 10.6073/pasta/38dfdd998e1c9844d3f668188627475a
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 2008-05-25
DOI: 10.6073/pasta/4a2c2c06c2ba3ab412da7c1b157df50a
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-07-10
DOI: 10.6073/pasta/5cbee4f62663947e3c8330f5dafc9f7b
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-10-14
DOI: 10.6073/pasta/b01e1a8267bbd8b962d64bb311fddfab
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-08-27
DOI: 10.6073/pasta/bfd1a25e18f4011f5989bc35369fcb3c
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-07-26
DOI: 10.6073/pasta/dbd8e0d9dff03fd04c665e481718fbc8
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 2003-07-20
DOI: 10.14457/ku.the.2006.1038
title: ความหลากหลายของ Bacillus thuringiensis ในจังหวัดกระบี่ และประสิทธิภาพในการควบคุมแมลงศัตรูพืช /
DOI: 10.14457/ku.the.2007.765
title: ความหลากชนิดและการแพร่กระจายตามระดับความสูงของสัตว์สะเทินน้ำสะเทินบกบริเวณลำห้วยลำตะคองในอุทยานแห่งชาติเขาใหญ่
DOI: 10.14457/ku.the.2007.766
title: ความหลากชนิดและนิเวศวิทยาของประชาคมปลาในนาข้าว ในจังหวัดปทุมธานีภาคกลางของประเทศไทย /
DOI: 10.14457/ku.the.2009.758
title: ความหลากชนิดและการแพร่กระจายของสัตว์เลื้อยคลาน ในสังคมป่าและฤดูกาลต่างกันของสถานีวิจัยสิ่งแวดล้อมสะแกราช จังหวัดนครราชสีมา /
DOI: 10.15785/sbgrid/98
title: X-Ray Diffraction data from IRAK4 Kinase Domain Dimer, source of 4U97 structure

description: Native data
DOI: 10.6073/pasta/1897e2993c4cbca97e8e7b312924bb76
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 2008-07-28
DOI: 10.6073/pasta/219ae17007bb392a43d9d4991b3cbe1f
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-12-01
DOI: 10.6073/pasta/283dba58c430eec3bba582a6a1d9a327
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 1990-06-09
DOI: 10.6073/pasta/382d960e06f73b9b233539ad97d5aea1
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 2003-11-25
DOI: 10.6073/pasta/4d9867afb22fb7d75412dcd8f7ae179e
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 2008-08-13
DOI: 10.6073/pasta/55ce4175b5fea2e50cddc17230fb7483
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 2000-01-12
DOI: 10.6073/pasta/5652f860c2c088cb790319fa13491201
title: Landsat Enhanced Thematic Mapper image data for Coweeta LTER collected on 1988-12-17
DOI: 10.6073/pasta/598196b0f0285e07dd013eaa9a5e0e7d
title: Landsat Enhanced Thematic Mapper image data for Florida Coastal Everglades LTER collected on 1999-12-27
DOI: 10.5281/zenodo.10020096
title: Supplementary Tables for "Population-level transposable element expression dynamics influence trait evolution in a fungal crop pathogen"

description: Supplementary Table S1: Genomic localization of TEs in gene elements and 10 kb windows upstream and downstream of the transcription start site (TSS) in the reference genome IPO323.
Supplementary Table S2: Genome-wide TE insertion polymorphism (TIPs) in the pathogen population. 0 represents TE absence and 1 represents TE presence.
Supplementary Table S3: Gene expression (log transformed RPKM) values across the population.
Supplementary Table S4: Locus-specific transcript abundance at individual TE loci (FPKM) across individuals.
Supplementary Table S5: Percent of expressed copies within each TE family in the reference genome IPO323 and percent expressed TE copies in each TE family across the population.
Supplementary Table S6: Linkage disequilibrium of TIP in the genome and neighboring SNPs within the 600bp distance from the TE loci.
Supplementary Table S7: Genome-wide association mapping of the virulence-associated trait (PLACP: percent leaf area covered by pycnidia) and TE insertion polymorphisms in the genome.
Supplementary Table S8: metabolite peak variation in the pathogen population for individual isolates
Supplementary Table S9: TIPs in the genome significantly associated with metabolite peak intensity variation in the pathogen population (filtered by Bonferroni threshold).
Supplementary Table S10: SRA accession list of RNAseq reads.
DOI: 10.5281/zenodo.10020095
title: Supplementary Tables for "Population-level transposable element expression dynamics influence trait evolution in a fungal crop pathogen"

description: Supplementary Table S1: Genomic localization of TEs in gene elements and 10 kb windows upstream and downstream of the transcription start site (TSS) in the reference genome IPO323.
Supplementary Table S2: Genome-wide TE insertion polymorphism (TIPs) in the pathogen population. 0 represents TE absence and 1 represents TE presence.
Supplementary Table S3: Gene expression (log transformed RPKM) values across the population.
Supplementary Table S4: Locus-specific transcript abundance at individual TE loci (FPKM) across individuals.
Supplementary Table S5: Percent of expressed copies within each TE family in the reference genome IPO323 and percent expressed TE copies in each TE family across the population.
Supplementary Table S6: Linkage disequilibrium of TIP in the genome and neighboring SNPs within the 600bp distance from the TE loci.
Supplementary Table S7: Genome-wide association mapping of the virulence-associated trait (PLACP: percent leaf area covered by pycnidia) and TE insertion polymorphisms in the genome.
Supplementary Table S8: metabolite peak variation in the pathogen population for individual isolates
Supplementary Table S9: TIPs in the genome significantly associated with metabolite peak intensity variation in the pathogen population (filtered by Bonferroni threshold).
Supplementary Table S10: SRA accession list of RNAseq reads.
DOI: 10.18739/a2ns0m02d
title: Photograph-based seed cone counts of white spruce (Picea glauca) trees from treeline field sites across the Brooks Range, Alaska 2019-2022

description: Photograph-derived counts of seed cones on white spruce (Picea glauca) trees at elevational (alpine) & lower (arctic) treelines at 19 research sites along a west-east gradient in Alaska's Brooks Range. Photographs are from a single angle and thus represent a "cone production index" rather than a complete count of all the cones on a tree. The general purpose of the sampling was to examine west-east variation in white spruce growth and reproduction responses to changes in climatic gradients and ongoing climate change.
DOI: 10.6084/m9.figshare.24354655
title: Genotyping-by-sequencing (GBS) - Cannabis clones

description: VCF file composed of genetic variant data resulting from GBS analysis of cannabis clones.
DOI: 10.34740/kaggle/dsv/6734694
title: BBC News
DOI: 10.25934/pr00007520
title: ACEi/ARB medications for hospitalized patients with COVID-19 – an individual patient data (IPD) based pooled analysis

description: ACEi/ARB medications might be beneficial in COVID-19 due to inhibition of viral entry into pneumocytes and alteration of local inflammatory and vasoconstriction/vasodilation balance. The current preclinical and clinical database, albeit limited, suggests equipoise or potential benefit for these medications in hospitalized patients with COVID-19.

This study is designed to confirm our hypothesis that treatment of hospitalized patients with SARS-CoV-2 infection with ACEi/ARB medications will improve clinical outcome in comparison with control treatments.

The necessity of this research is urgent given that over 650,000 Americans have died of COVID-19, daily deaths again surpassed 2,000 at the peak of the delta variant surge, and thus there is a continued need for effective therapeutics.

Currently, starting ACEi/ARB for COVID-19 de novo is not standard because supportive data is weak and evolving. If administration of simple and inexpensive ACEi/ARB medications in COVID-19 will decrease morbidity and mortality, the drugs can have an important effect on outcome of many thousands of hospitalized patients internationally.

This study will be the first IPD-meta analysis of ACEi/ARB medications in COVID-19 and only the third IPD-meta analysis in COVID-19 more broadly.

After down selection of targeted RCTs, finalization of data harmonization spreadsheets and deidentification/anonymization processes, completion of data sharing agreements, trialists will collate IPD data per supplied data harmonization spreadsheets, and upload the data to Vivil. Data will be transferred to JHU where analysis per our prespecified SAP will occur using Bayesian statistical methods. The study, including its SAP, were registered on PROSPERO (CRD42021254261).
DOI: 10.25934/pr00007542
title: Vedolizumab vs. Adalimumab in Ulcerative Colitis: Validation of Indirect Comparisons

description: Ulcerative colitis (UC) affects over 120,000 Canadians and is an inflammatory bowel disease that affects the large intestine and is characterized by diarrhea, rectal bleeding, abdominal pain, urgency, and tenesmus. Patients with severe UC and/or disease that cannot be adequately controlled with corticosteroids are candidates for biologic monoclonal antibody treatments such as vedolizumab and adalimumab.

Vedolizumab and adalimumab are two biologic therapies that have demonstrated efficacy in achieving and maintaining remission through several pivotal placebo-controlled trials, including ULTRA 1 (NCT00385736), ULTRA 2 (NCT00408629), and GEMINI 1 (NCT00783718). Recently, the VARSITY trial (NCT02497469) demonstrated the superiority of vedolizumab to adalimumab among patients with moderate to severe UC. While studies comparing provide robust evidence to inform positioning of therapies, trials are costly and time-consuming. Therefore, there is increasing interest in performing indirect comparisons of biologics using patient-level data from different placebo-controlled clinical trials. However, the reliability of these comparisons relative to trials comparing active therapies remains unclear.

The Mayo Score is a tool that is used to determine UC disease activity and is comprised of four patient-reported and endoscopic assessments: stool frequency, rectal bleeding, endoscopic findings, and physician’s global assessment. Each parameter is scored from 0 to 3, with higher scores indicating greater disease severity. The total Mayo Score ranges from 0 to 12, while the partial Mayo Score excludes the endoscopic subscore and thus ranges from 0 to 9. While the Mayo Score has been widely used in clinical trials for UC as primary endpoints, mucosal healing (determined by endoscopy) remains an important target of treatment as well.

The primary objective of this study is to compare the efficacy of vedolizumab and adalimumab to achieve post-induction (week 6/8) mucosal healing as determined by the Mayo Score. The secondary objectives of this study include clinical remission at one-year and mucosal healing at one-year. Additionally, clinical response, reduction in markers of disease activity (e.g. fecal calprotectin, C-reactive protein), and reduction in histologic measures of disease activity at post-induction (week 6/8) and one-year will be analyzed.

Data from GEMINI 1 and VARSITY, which is being requested from Vivli, will be pooled to obtain a cohort of biologic-naïve UC patients treated with adalimumab. Biologic-naïve patients treated with adalimumab in ULTRA 1 and ULTRA 2, which is also being requested from Vivli, will be pooled to comprise the adalimumab cohort.
DOI: 10.34740/kaggle/dsv/6734703
title: Youtube Trending Video - Taiwan & Hong Kong
DOI: 10.25934/pr00007609
title: The impact of albiglutide on heart failure outcomes among patients with type 2 diabetes with and without heart failure at baseline

description: Type 2 diabetes is a condition that affects the regulation of glucose in the body and has many deleterious consequences to the organism. Cardiovascular complications, including heart failure (HF) are common in patients with diabetes. The number of people with diabetes rose from 108 million in 1980 to 422 million in 2014. Prevalence has been rising more rapidly in low- and middle-income countries than in high-income countries. Between 2000 and 2016, there was a 5% increase in premature mortality from diabetes. In 2019, diabetes was the ninth leading cause of death with an estimated 1.5 million deaths directly caused by diabetes (WHO, 2021).

Patients with type 2 diabetes (T2D) have a high risk of heart failure (HF) events. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (a drug class that lowers blood sugar levels by reducing the amount of glucose being absorbed by the kidneys so that it passes out in greater amounts in urine), have been shown to reduce HF events by 30-35%. On the other hand, glucagon-like peptide 1 receptor agonists (GLP-1Ra) (a drug class that increases the production of insulin by the pancreas, particularly after meals, which then regulates the amount of glucose in the blood), have been shown to reduce the risk of myocardial infarction and stroke, but may have a smaller magnitude effect on HF events (around 10% relative reduction). Consequently, uncertainty remains about the HF effects of GLP-1Ra, particularly among patients with established HF. As GLP1-Ra may increase heart rate, these agents may not be beneficial to patients with established HF; however, this clinically important hypothesis has not been adequately explored using prospective randomized data. 

Albiglutide is a GLP-1Ra which is sufficiently longacting to be injected weekly. 

The cardiovascular safety and efficacy of albiglutide was tested in the Harmony Outcomes trial, that enrolled patients with type 2 diabetes and cardiovascular disease. Heart failure outcomes, particularly among patients with HF history have not been fully explored.

The present proposal aims to study the impact of albiglutide on heart failure (HF) outcomes among patients with type 2 diabetes, with and without HF at baseline (i.e., prior to randomization). Heart failure is a common complication of diabetes, which is associated with poor quality of life and a poor prognosis. The effect of GLP-1Ra, like albiglutide, on HF outcomes is uncertain. This proposal aims to fill this gap in knowledge by studying the efficacy and safety of albiglutide on HF outcomes in patients with type 2 diabetes and a high cardiovascular risk participating in the Harmony Outcomes trial.
DOI: 10.25934/pr00007654
title: Update of individual data meta-analysis of intra-articular corticosteroids in knee and hip osteoarthritis

description: Background:
Osteoarthritis (OA) is a highly prevalent and disabling condition with limited safe and effective treatment options available. Intra-articular corticosteroid injections are frequently utilised in knee or hip OA patients in the setting of unresponsiveness or intolerance to conservative treatment measures or common pharmacological agents such as non-steroidal anti-inflammatory drugs.
The aim of this individual patient data meta-analysis is to investigate the efficacy of intra-articular corticosteroid injections in patients with hip and knee OA.

Method and analysis:
A systematic literature search will be conducted for randomised clinical trials in corticosteroid intra-articular injection with placebo for knee and hip osteoarthritis. Literature searches will be conducted through Pubmed (Medline), EMBASE, Web of Science, Cochrane Central, and SCOPUS. Individual patient data from each study will be requested and obtained from the corresponding authors of the trials. Risk of bias will be assessed using the Cochrane Collaboration’s tool.

The primary outcome will be pain severity at short term with secondary outcomes being pain severity at other time points
DOI: 10.25934/pr00007660
title: Predictors of placebo response to intra-articular therapy in osteoarthritis - an individual patient data meta-analysis 

description: Background:
Osteoarthritis (OA) is a highly prevalent and disabling condition with limited safe and effective treatment options available. Intra-articular therapies are increasingly being utilised, especially in patients with knee or hip osteoarthritis. However, whether the effect of these agents is due to active treatment or placebo remains largely unknown. The placebo effect is part of treatment effect and identifying the magnitude and potential predictors of this effect in intra-articular therapies will inform the design of future trials and clinical practice. 

Method and analysis:
A systematic literature search will be conducted for randomised clinical trials comparing corticosteroid and viscosupplementation/hyaluronic acid intra-articular injection with placebo for knee and hip osteoarthritis. Literature searches will be conducted through Pubmed (Medline), EMBASE, Web of Science, Cochrane Central, and SCOPUS from inception to May 2018 . Individual patient data from each study will be requested and obtained from the corresponding authors of the trials. Risk of bias will be assessed using the Cochrane Collaboration’s tool.

The primary outcome will be change in pain from baseline. Secondary outcomes will be change in function and patient global assessment. Predictors of response to treatment that will be assessed include patient characteristics (age, gender, bilateral versus unilateral disease, other joints OA involvement, radiographic severity, pain severity and presence of inflammatory features based on imaging and physical examination) , intervention characteristics (aspirate volume, frequency of injection, volume of injection, and intra-articular injection approach), and trial characteristics (clinical setting , , blinding, use of intention to treat analysis, funder/sponsor). We will report our results using the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA)-IPD guidelines.