cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24754974
title: Supplementary Material for: Effect on kidney function recovery guiding decongestion with VExUS in patients with cardiorenal syndrome 1, a randomized control trial

description: Introduction: In cardiorenal syndrome type 1 (CRS1) vascular congestion is central to the pathophysiology of heart failure and thus a key target for management. The Venous Evaluation by Ultrasound System (VExUS) could guide decongestion effectively and thereby improve outcomes.
Methods: In this randomized clinical trial, patients with CRS1 (i.e., increase in creatinine ≥0.3 mg/dL) were randomized to guide decongestion with VExUS compared to usual clinical evaluation. The primary endpoint was to assess kidney function recovery (KFR), and the key secondary endpoint was decongestion evaluated by physical examination and changes in brain natriuretic peptide (BNP) and CA-125. Exploratory endpoints included days of hospitalization and mortality. 
Results: From March 2022 to February 2023, a total of 140 patients were randomized 1:1 (70 in the VExUS and 70 in the Control group). KFR was not statistically different between groups. However, VExUS improved more than twice the odds to achieve decongestion (OR 2.6, 95% CI 1.9-3.0, p=0.01) and the odds to reach a decrease of BNP &gt;30% (OR 2.4; 95% CI 1.3-4.1, p = 0.01). The survival at 90 days, recongestion and CA-125 were similar between groups.
Conclusion: In patients with CRS1, we observed that VExUS-guided decongestion did not improve the probability of KFR but improved the odds to achieve decongestion.
DOI: 10.6084/m9.figshare.24754974.v1
title: Supplementary Material for: Effect on kidney function recovery guiding decongestion with VExUS in patients with cardiorenal syndrome 1, a randomized control trial

description: Introduction: In cardiorenal syndrome type 1 (CRS1) vascular congestion is central to the pathophysiology of heart failure and thus a key target for management. The Venous Evaluation by Ultrasound System (VExUS) could guide decongestion effectively and thereby improve outcomes.
Methods: In this randomized clinical trial, patients with CRS1 (i.e., increase in creatinine ≥0.3 mg/dL) were randomized to guide decongestion with VExUS compared to usual clinical evaluation. The primary endpoint was to assess kidney function recovery (KFR), and the key secondary endpoint was decongestion evaluated by physical examination and changes in brain natriuretic peptide (BNP) and CA-125. Exploratory endpoints included days of hospitalization and mortality. 
Results: From March 2022 to February 2023, a total of 140 patients were randomized 1:1 (70 in the VExUS and 70 in the Control group). KFR was not statistically different between groups. However, VExUS improved more than twice the odds to achieve decongestion (OR 2.6, 95% CI 1.9-3.0, p=0.01) and the odds to reach a decrease of BNP &gt;30% (OR 2.4; 95% CI 1.3-4.1, p = 0.01). The survival at 90 days, recongestion and CA-125 were similar between groups.
Conclusion: In patients with CRS1, we observed that VExUS-guided decongestion did not improve the probability of KFR but improved the odds to achieve decongestion.
DOI: 10.6084/m9.figshare.24499783
title: Supplementary Material for: Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2

description: Introduction: Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes, and to analyze the correlation between the image and pathology parameters.
Method: Tumor bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the same mouse with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 at 20, 60 and 120 min. The image parameters were obtained, including the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), standard deviation of SUVmean (SD), tumor volume and coefficient of variation (CoV). Immunohistochemistry of the tumor was performed after imaging to obtain positive rate of SSTR2. Statistical analysis was performed to analyze the differences among the three imaging techniques and the correlations between the relative imaging parameter and immunohistochemistry (IHC). 
Result: The SUVmax of [18F]AlF-NOTA-JR11 at 20 and 60 min was higher than that of [68Ga]Ga-DOTA-TATE (P=0.0015, 0.0035) and [68Ga]Ga-DOTA-JR11 (P=0.033, 0.019), and no significant difference was found in the other groups (P&gt;0.05). There was a significant positive correlation between the positive rate and SUVmean of tumors with three tracers (P&lt;0.05). However, a significant negative correlation between the positive rate and CoV was found only in the [68Ga]Ga-DOTA-TATE group at 60 min and 120 min (P=0.048, 0.026).
Conclusion: [18F]AlF-NOTA-JR11 is more suitable for SSTR imaging within an hour than other two tracers. SUVmean of whole tumor can become an indicator for evaluating the positive rate of IHC, and the higher SUVmean of three tracers means a higher positive rate. However, the CoV is not applicable to the two antagonist tracers for evaluating the positive rate.
DOI: 10.6084/m9.figshare.24499783.v1
title: Supplementary Material for: Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2

description: Introduction: Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes, and to analyze the correlation between the image and pathology parameters.
Method: Tumor bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the same mouse with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 at 20, 60 and 120 min. The image parameters were obtained, including the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), standard deviation of SUVmean (SD), tumor volume and coefficient of variation (CoV). Immunohistochemistry of the tumor was performed after imaging to obtain positive rate of SSTR2. Statistical analysis was performed to analyze the differences among the three imaging techniques and the correlations between the relative imaging parameter and immunohistochemistry (IHC). 
Result: The SUVmax of [18F]AlF-NOTA-JR11 at 20 and 60 min was higher than that of [68Ga]Ga-DOTA-TATE (P=0.0015, 0.0035) and [68Ga]Ga-DOTA-JR11 (P=0.033, 0.019), and no significant difference was found in the other groups (P&gt;0.05). There was a significant positive correlation between the positive rate and SUVmean of tumors with three tracers (P&lt;0.05). However, a significant negative correlation between the positive rate and CoV was found only in the [68Ga]Ga-DOTA-TATE group at 60 min and 120 min (P=0.048, 0.026).
Conclusion: [18F]AlF-NOTA-JR11 is more suitable for SSTR imaging within an hour than other two tracers. SUVmean of whole tumor can become an indicator for evaluating the positive rate of IHC, and the higher SUVmean of three tracers means a higher positive rate. However, the CoV is not applicable to the two antagonist tracers for evaluating the positive rate.
DOI: 10.5281/zenodo.10461724
title: SphereCraft - record 7

description: This is record 7 (of a total of 9 records) of the dataset published under the title SphereCraft: A Dataset for Spherical Keypoint Detection, Matching and Camera Pose Estimation. See conference details below.
DOI: 10.5281/zenodo.10461725
title: SphereCraft - record 7

description: This is record 7 (of a total of 9 records) of the dataset published under the title SphereCraft: A Dataset for Spherical Keypoint Detection, Matching and Camera Pose Estimation. See conference details below.
DOI: 10.6084/m9.figshare.24948219
title: Supplementary Material for: Expert pathology for GTD: towards an international multidisciplinary team meeting (MDT)

description: Background:
Gestational trophoblastic disease, comprising hydatidiform moles and gestational trophoblastic tumours, is extremely rare. Exact diagnosis is crucial to indicate the appropriate treatment and to prevent complications. The scarcity and variability in the number of cases available for reporting, lack of specialized training in GTD and non-existence of refresher courses available implies that the pathologist dealing with these rare and at times extremely challenging cases are not completely confident in their diagnosis. 

Objectives:
To explores the benefits of implementation of an international multidisciplinary conference (virtual) to aid diagnosis of difficult cases and support clinical management of GTD. 

Methods: 
A short survey was circulated to all 46 members of the EOTTD pathology and genetics working party, and further spread to other colleagues who practice GTD. This showed that the pathologists and geneticists working with GTD patients do not feel adequately supported and equipped with dealing with these rare diseases.

Outcome: 
Virtual cross-border MDTs were initiated in April 2022, bringing together participants from 11 European countries on a bi-yearly basis. Mean numbers of 3 patients are discussed during the MDTs followed by 3-4 QA cases. A participant survey was conducted at the end of virtual meeting with an average satisfaction rate of 9.5. The pathologists felt supported and benefited from networking and clinical collaboration.

Conclusions and Outlook:
This international multidisciplinary team meeting (MDT) continues to provide support in managing the uncertainty with difficult and rare cases and enhances the pathologists training and experience. The frequency of meetings and the number of cases discussed per meeting will be increased in 2023 given the positive response. This will empower individuals and organisations to work together and improve diagnosis and the prognosis for these young patients.
DOI: 10.6084/m9.figshare.24948221
title: Patients’ perceptions of climate-sensitive health counselling in primary care: Qualitative results from Germany

description: Climate change is the greatest threat to global health in the twenty first century, yet combating it entails substantial health co-benefits. Physicians and other health professionals have not yet fully embraced their responsibilities in the climate crisis, especially about their communication with patients. While medical associations are calling on physicians to integrate climate change into health counselling, there is little empirical evidence about corresponding perceptions of patients. This study aimed to explore primary care patients’ perceptions of climate-sensitive health counselling. From July to December 2021, 27 qualitative interviews with patients were conducted and analysed using thematic analysis. A purposive sampling technique was applied to identify patients who had already experienced climate-sensitive health counselling in Germany. Patients’ perceptions of climate-sensitive health counselling were characterised by a high level of acceptance, which was enhanced by stressing the link between climate change and health, being credible concerning physician’s own climate-friendly lifestyle, building upon good therapeutic relationships, creating a sense of solidarity, and working in a patient centred manner. Challenges and risks for acceptance were patients’ disinterest or surprise, time constraints, feared politicisation of consultations, and evoking feelings of guilt and shame. These findings suggest that primary care patients can accept climate-sensitive health counselling, if it follows certain principles of communication, including patient-centredness. Our findings can be useful for developing communication guidelines, respective policies as well as well-designed intervention studies, which are needed to test the health and environmental effects of climate-sensitive health counselling. Climate-sensitive health counselling was accepted in a qualitative patient sample in Germany. Patient-centred communication and a link to individual health contributed to acceptance while time-constraints, politisation and feelings of guilt were potential challenges. Further research is needed to investigating patients’ acceptance and effects of climate-sensitive health counselling in larger samples.
DOI: 10.6084/m9.figshare.24948221.v1
title: Patients’ perceptions of climate-sensitive health counselling in primary care: Qualitative results from Germany

description: Climate change is the greatest threat to global health in the twenty first century, yet combating it entails substantial health co-benefits. Physicians and other health professionals have not yet fully embraced their responsibilities in the climate crisis, especially about their communication with patients. While medical associations are calling on physicians to integrate climate change into health counselling, there is little empirical evidence about corresponding perceptions of patients. This study aimed to explore primary care patients’ perceptions of climate-sensitive health counselling. From July to December 2021, 27 qualitative interviews with patients were conducted and analysed using thematic analysis. A purposive sampling technique was applied to identify patients who had already experienced climate-sensitive health counselling in Germany. Patients’ perceptions of climate-sensitive health counselling were characterised by a high level of acceptance, which was enhanced by stressing the link between climate change and health, being credible concerning physician’s own climate-friendly lifestyle, building upon good therapeutic relationships, creating a sense of solidarity, and working in a patient centred manner. Challenges and risks for acceptance were patients’ disinterest or surprise, time constraints, feared politicisation of consultations, and evoking feelings of guilt and shame. These findings suggest that primary care patients can accept climate-sensitive health counselling, if it follows certain principles of communication, including patient-centredness. Our findings can be useful for developing communication guidelines, respective policies as well as well-designed intervention studies, which are needed to test the health and environmental effects of climate-sensitive health counselling. Climate-sensitive health counselling was accepted in a qualitative patient sample in Germany. Patient-centred communication and a link to individual health contributed to acceptance while time-constraints, politisation and feelings of guilt were potential challenges. Further research is needed to investigating patients’ acceptance and effects of climate-sensitive health counselling in larger samples.
DOI: 10.5281/zenodo.10461678
title: Silence of APN2 gene reveals the trade-offs for acquiring Cry1Ac resistance in Plutella xylostella

description: In this study, Aminopeptidase-N 2 (APN2), a Cry toxin receptor gene of P. xylostella, was knocked down by RNA interference, resulting in improved resistance to Cry1Ac. It was also found that the APN2-knocked-down P. xylostella had significantly higher larval mortality than the control, while the pupation rate, pupal weight, eclosion rate, fecundity(egg/female), hatchability, and female adult longevity were significantly lower than that of the control. These results illustrate that if Cry1Ac resistance was obtained only through the reduction of APN2 expression, P. xylostella would need to incur some fitness costs for it.
DOI: 10.5281/zenodo.10461679
title: Silence of APN2 gene reveals the trade-offs for acquiring Cry1Ac resistance in Plutella xylostella

description: In this study, Aminopeptidase-N 2 (APN2), a Cry toxin receptor gene of P. xylostella, was knocked down by RNA interference, resulting in improved resistance to Cry1Ac. It was also found that the APN2-knocked-down P. xylostella had significantly higher larval mortality than the control, while the pupation rate, pupal weight, eclosion rate, fecundity(egg/female), hatchability, and female adult longevity were significantly lower than that of the control. These results illustrate that if Cry1Ac resistance was obtained only through the reduction of APN2 expression, P. xylostella would need to incur some fitness costs for it.
DOI: 10.6084/m9.figshare.24850776
title: Supplementary Material for: Combined prognostic impact of two quick frailty assessments in acute heart failure

description: Introduction: We aimed to investigate the prognostic impact of frailty (defined by the Study of Osteoporotic Fracture [SOF] index and the Clinical Frailty Scale [CFS]) in hospitalized patients with acute decompensated heart failure (HF).
Methods: A total of 1053 patients over 75 years of age, who were primarily admitted to hospital with a diagnosis of acute decompensated HF, were enrolled. The prognostic value of frailty by the two tools for predicting all-cause mortality was analyzed using multivariate Cox regression models.
Results: The incidence of frailty was 57.1% when using the SOF index, 37.6% when using the CFS, and 23.3% when using both tools. Frailty, via the SOF index or CFS, was an independent predictor of all-cause mortality in model 1, after adjustment for significantly associated factors by univariate analysis (hazard ratio [HR] 1.38, 95% confidence interval [CI] 1.04–1.84, P =0.027; HR 1.53, 95% CI 1.15–2.05, P =0.003, respectively), and in model 2, after adjustment for previously reported prognostic factors (HR 1.42, 95% CI 1.07–1.89, P =0.015; HR 1.56, 95% CI 1.17–2.07, P =0.002, respectively). Compared to non-frail patients, frail patients via both tools had a significantly higher incidence of all-cause mortality in models 1 (adjusted HR 2.16, 95% CI 1.42−3.29, P &lt;0.001) and 2 (adjusted HR 2.30, 95% CI 1.51−3.50, P &lt;0.001).
Conclusions: Combined frailty screening using the SOF index and CFS contributed to stratify the risk of mortality in patients with acute decompensated HF.
DOI: 10.6084/m9.figshare.24908400
title: Supplementary Material for: Methylation of the oxytocin, oxytocin receptor, and vasopressin gene pro-moters in tobacco use disorder during cessation

description: Introduction: Vasopressin (AVP) and oxytocin (OT) exert sex-specific effects on social pair bonding and stress reactions while also influencing craving in substance use disorders. In this regard, in-tranasal OT and AVP antagonists present potential treatments for tobacco use disorder (TUD). Since transcription of both hormones is also regulated by gene methylation, we hypothesized sex-specific changes in methylation levels of the AVP, OT and oxytocin receptor (OXTR) gene during nicotine withdrawal. Methods: The study population consisted of 49 smokers (29 males, 20 fe-males) and 51 healthy non-smokers (25 males, 26 females). Blood was drawn at day 1, day 7, and day 14 of smoking cessation. Craving was assessed with the questionnaire on smoking urges (QSU). Results: Throughout cessation, mean methylation of the OT promoter gene increased in males and decreased in females. OXTR receptor methylation decreased in females, while in males it was sig-nificantly lower at day 7. Regarding the AVP promoter, mean methylation increased in males while there were no changes in females. Using mixed linear modeling, CpG position, time point, sex, and the interaction of time point and sex as well as time point, sex, and QSU had a significant fixed ef-fect on OT and AVP gene methylation. The interaction effect suggests that sex, time point and QSU are interrelated, meaning that, depending on the sex, methylation could be different at different time points and vice versa. There was no significant effect of QSU on mean OXTR methylation. Dis-cussion/Conclusion: We identified differences at specific CpGs between controls and smokers in OT and AVP and in overall methylation of the AVP gene. Furthermore, we found sex specific changes in mean methylation levels of the mentioned genes throughout smoking cessation, underlining the relevance of sex in the oxytocin and vasopressin system. This is the first study on epigenetic regula-tion of the OT promoter in TUD. Our results have implications for research on the utility of the AVP and OT system for treating substance craving. Future studies on both targets need to analyze their effect in the context of sex, social factors, and gene regulation.
DOI: 10.6084/m9.figshare.24908400.v1
title: Supplementary Material for: Methylation of the oxytocin, oxytocin receptor, and vasopressin gene pro-moters in tobacco use disorder during cessation

description: Introduction: Vasopressin (AVP) and oxytocin (OT) exert sex-specific effects on social pair bonding and stress reactions while also influencing craving in substance use disorders. In this regard, in-tranasal OT and AVP antagonists present potential treatments for tobacco use disorder (TUD). Since transcription of both hormones is also regulated by gene methylation, we hypothesized sex-specific changes in methylation levels of the AVP, OT and oxytocin receptor (OXTR) gene during nicotine withdrawal. Methods: The study population consisted of 49 smokers (29 males, 20 fe-males) and 51 healthy non-smokers (25 males, 26 females). Blood was drawn at day 1, day 7, and day 14 of smoking cessation. Craving was assessed with the questionnaire on smoking urges (QSU). Results: Throughout cessation, mean methylation of the OT promoter gene increased in males and decreased in females. OXTR receptor methylation decreased in females, while in males it was sig-nificantly lower at day 7. Regarding the AVP promoter, mean methylation increased in males while there were no changes in females. Using mixed linear modeling, CpG position, time point, sex, and the interaction of time point and sex as well as time point, sex, and QSU had a significant fixed ef-fect on OT and AVP gene methylation. The interaction effect suggests that sex, time point and QSU are interrelated, meaning that, depending on the sex, methylation could be different at different time points and vice versa. There was no significant effect of QSU on mean OXTR methylation. Dis-cussion/Conclusion: We identified differences at specific CpGs between controls and smokers in OT and AVP and in overall methylation of the AVP gene. Furthermore, we found sex specific changes in mean methylation levels of the mentioned genes throughout smoking cessation, underlining the relevance of sex in the oxytocin and vasopressin system. This is the first study on epigenetic regula-tion of the OT promoter in TUD. Our results have implications for research on the utility of the AVP and OT system for treating substance craving. Future studies on both targets need to analyze their effect in the context of sex, social factors, and gene regulation.
DOI: 10.25835/2jc9g610
title: Temperature measurement Rotary friction welding 2setup

description: Temperature measurement Rotary friction welding for validation experiments