cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4569865.v1
title: Supplementary Material for: Risk Factors Assessed in Adolescence and the Later Risk of Stroke in Men: A 33-Year Follow-Up Study

description: <b><i>Background:</i></b> Stroke is a common cause of death, and a leading contributor to long-term disability. The cost associated with the disease is great. Several modifiable risk factors for stroke have been found in older cohorts; however, no study to date has investigated the effects of these risk factors from late adolescence. <b><i>Methods:</i></b> The study cohort comprised 811,579 Swedish men (mean age, 18 years) that participated in the mandatory military conscription service in Sweden between 1969 and 1986. Some risk factors for stroke, such as body mass index, systolic and diastolic blood pressure, and cognitive function, were assessed at conscription. Aerobic fitness was also assessed at conscription, using a braked ergometer cycle test. Other risk factors for stroke, including stroke in subjects' parents, and socioeconomic factors including highest achieved level of education and annual income 15 years after conscription, were collected through national register linkage using the personal identification number.<b> </b>Stroke diagnosis among the study participants was tracked in the National Hospital Discharge Patient Register. <b><i>Results:</i></b> During a median follow-up period of 33 years 6,180 ischemic strokes and 2,104 hemorrhagic strokes were diagnosed in the cohort at a mean age of 47.9 years. Strong independent risk factors (all p &lt;1.0 × 10−<sup>6</sup>) for ischemic stroke included low aerobic fitness (hazard ratio [HR], 0.84 per standard deviation [SD] increase), high BMI (HR, 1.15 per SD increase), diabetes (HR, 2.85), alcohol intoxication (HR, 1.93), low annual income (HR, 0.85 per SD decrease), and stroke in the mother (HR, 1.31). Similar risk factors were found for hemorrhagic stroke including low aerobic fitness (HR, 0.82 per SD increase), high BMI (HR, 1.18 per SD increase) alcohol intoxication (HR, 2.92), diabetes (HR, 2.06), and low annual income (HR, 0.75). The population attributable risks associated with all evaluated risk factors were 69% for ischemic stroke and 88% for hemorrhagic stroke (p &lt; 0.001 for both). <b><i>Conclusions:</i></b> In the present study we have shown that several known risk factors for stroke are present already in late adolescence, and that they are independent of each other. The strongest risk factors were low physical fitness, high BMI, diabetes, low annual income and a maternal history of stroke. Several of the aforementioned risk factors are potentially modifiable.
DOI: 10.6084/m9.figshare.4569847
title: Supplementary Material for: Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers

description: <b><i>Objecitive:</i></b> Fucosyltransferase 8 (FUT8), the only enzyme responsible for the core α1,6-fucosylation of asparagine-linked oligosaccharides of glycoproteins, is a vital enzyme in cancer development and progression. We examined FUT8 expression in non-small cell lung cancers (NSCLCs) to analyze its clinical significance. We also examined the expression of guanosine diphosphate-mannose-4,6-dehydratase (GMD), which is imperative for the synthesis of fucosylated oligosaccharides. <b><i>Methods:</i></b> Using immunohistochemistry, we evaluated the expression of FUT8 and GMD in relation to patient survival and prognosis in potentially curatively resected NSCLCs. <b><i>Results:</i></b> High expression of FUT8 was found in 67 of 129 NSCLCs (51.9%) and was significantly found in non-squamous cell carcinomas (p = 0.008). High expression of FUT8 was associated with poor survival (p = 0.03) and was also a significant and independent unfavorable prognostic factor in patients with potentially curatively resected NSCLCs (p = 0.047). High expression of GMD was significantly associated with high FUT8 expression (p = 0.04). <b><i>Conclusions:</i></b> High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. The analysis of FUT8 expression and its core fucosylated products may provide new insights for the therapeutic targets of NSCLCs.
DOI: 10.6084/m9.figshare.4569877.v1
title: First high-resolution analysis of the ν<sub>1</sub>, ν<sub>3</sub> and ν<sub>1</sub> + ν<sub>3</sub> bands of sulphur dioxide <sup>33</sup>S<sup>16</sup>O<sub>2</sub>

description: High-resolution spectra of <sup>33</sup>S<sup>16</sup>O<sub>2</sub> have been recorded for the first time in the 8 and 4 µm spectral regions.The ν<sub>1</sub>, ν<sub>3</sub> and ν<sub>1</sub> + ν<sub>3</sub> bands of the <sup>33</sup>S<sup>16</sup>O<sub>2</sub> have been analysed up to very high quantum numbers.Accurate ro-vibrational upper states constants have been determined. High-resolution spectra of <sup>33</sup>S<sup>16</sup>O<sub>2</sub> have been recorded for the first time in the 8 and 4 µm spectral regions. The ν<sub>1</sub>, ν<sub>3</sub> and ν<sub>1</sub> + ν<sub>3</sub> bands of the <sup>33</sup>S<sup>16</sup>O<sub>2</sub> have been analysed up to very high quantum numbers. Accurate ro-vibrational upper states constants have been determined. Fourier transform spectra of sulphur dioxide <sup>33</sup>S<sup>16</sup>O<sub>2</sub> have been recorded in the 8.0 and 4.0 µm spectral regions at a resolution of 0.0015 cm<sup>−1</sup> using a Bruker IFS 125HR spectrometer leading to the observation of the ν<sub>1</sub>, ν<sub>3</sub> and ν<sub>1</sub> + ν<sub>3</sub> vibrational bands of the <sup>33</sup>S<sup>16</sup>O<sub>2</sub> molecule. The corresponding upper state ro-vibrational levels were fit using a Hamiltonian matrix taking into account a Coriolis Δ<i>K<sub>a</sub> </i> = 3 resonance between the ro-vibrational levels of the 1<sup>1</sup> and 3<sup>1</sup> vibrational states and a Watson-type Hamiltonian for the ro-vibrational levels of the 1<sup>1</sup> 3<sup>1</sup> vibrational state. In this way it was possible to reproduce the upper state ro-vibrational levels to within the experimental uncertainty; i.e. ∼0.20 × 10<sup>−3</sup> cm<sup>−1</sup>. Very accurate rotational and centrifugal distortion constants were derived from the fit together with the following band centres: ν<sub>0</sub> (ν<sub>1</sub>) = 1147.979535(60) cm<sup>−1</sup>, ν<sub>0</sub> (ν<sub>3</sub>) = 1353.335912(60) cm<sup>−1</sup> and ν<sub>0</sub> (ν<sub>1</sub> + ν<sub>3</sub>) = 2487.493732(30) cm<sup>−1</sup>.
DOI: 10.6084/m9.figshare.4569847.v1
title: Supplementary Material for: Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers

description: <b><i>Objecitive:</i></b> Fucosyltransferase 8 (FUT8), the only enzyme responsible for the core α1,6-fucosylation of asparagine-linked oligosaccharides of glycoproteins, is a vital enzyme in cancer development and progression. We examined FUT8 expression in non-small cell lung cancers (NSCLCs) to analyze its clinical significance. We also examined the expression of guanosine diphosphate-mannose-4,6-dehydratase (GMD), which is imperative for the synthesis of fucosylated oligosaccharides. <b><i>Methods:</i></b> Using immunohistochemistry, we evaluated the expression of FUT8 and GMD in relation to patient survival and prognosis in potentially curatively resected NSCLCs. <b><i>Results:</i></b> High expression of FUT8 was found in 67 of 129 NSCLCs (51.9%) and was significantly found in non-squamous cell carcinomas (p = 0.008). High expression of FUT8 was associated with poor survival (p = 0.03) and was also a significant and independent unfavorable prognostic factor in patients with potentially curatively resected NSCLCs (p = 0.047). High expression of GMD was significantly associated with high FUT8 expression (p = 0.04). <b><i>Conclusions:</i></b> High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. The analysis of FUT8 expression and its core fucosylated products may provide new insights for the therapeutic targets of NSCLCs.
DOI: 10.6084/m9.figshare.4569793
title: Audience files

description: Data on audience effet, with data on audience identity, kinship and description of the conflict (vocal/non vocal).
DOI: 10.6084/m9.figshare.4569835.v1
title: This time it’s different? Effects of the Eurovision Debate onyoung citizens’ and its consequence for EU democracy – evidence from a quasi-experiment in 24 countries

description: For the very first time in EU history, the 2014 EP elections provided citizens with the opportunity to influence the nomination of the Commission President by casting a vote for the main Europarties’ ‘lead candidates’. By subjecting the position of the Commission President to an open political contest, many experts have formulated the expectation that heightened political competition would strengthen the weak electoral connection between EU citizens and EU legislators, which some consider a root cause for the EU’s lack of public support. In particular, this contest was on display in the so-called ‘Eurovision Debate’, a televised debate between the main contenders for the Commission President broadcasted live across Europe. Drawing on a quasi-experimental study conducted in 24 EU countries, we find that debate exposure led to increased cognitive and political involvement and EU support among young citizens. Unfortunately, the debate has only reached a very small audience.
DOI: 10.6084/m9.figshare.4569793.v1
title: Audience files

description: Data on audience effet, with data on audience identity, kinship and description of the conflict (vocal/non vocal).
DOI: 10.6084/m9.figshare.4569835.v2
title: This time it’s different? Effects of the Eurovision Debate on young citizens’ and its consequence for EU democracy – evidence from a quasi-experiment in 24 countries

description: For the very first time in EU history, the 2014 EP elections provided citizens with the opportunity to influence the nomination of the Commission President by casting a vote for the main Europarties’ ‘lead candidates’. By subjecting the position of the Commission President to an open political contest, many experts have formulated the expectation that heightened political competition would strengthen the weak electoral connection between EU citizens and EU legislators, which some consider a root cause for the EU’s lack of public support. In particular, this contest was on display in the so-called ‘Eurovision Debate’, a televised debate between the main contenders for the Commission President broadcasted live across Europe. Drawing on a quasi-experimental study conducted in 24 EU countries, we find that debate exposure led to increased cognitive and political involvement and EU support among young citizens. Unfortunately, the debate has only reached a very small audience.
DOI: 10.6084/m9.figshare.4569742
title: Supplementary Material for: The Effect of Homoeologous Meiotic Pairing in Tetraploid Hordeum bulbosum L. × H. vulgare L. Hybrids on Alien Introgressions in Offspring

description: The pairing behaviour of the individual chromosome arms of <i>Hordeum vulgare </i>(<i>Hv</i>) with their homoeologous arms of <i>H. bulbosum </i>(<i>Hb</i>) at metaphase I of meiosis in tetraploid <i>Hb </i>× <i>Hv </i>hybrids and the frequencies of recombined <i>Hv</i> chromosome arms in selfed offspring were studied on differentially visualized chromosomes after fluorescent in situ hybridisation. The frequencies of paired <i>Hv-Hb</i> arms in the F<sub>2</sub> and F<sub>3</sub> hybrids were correlated with the frequencies of recombined <i>Hv</i> chromosomes in progenies. Self-generation of hybrids, the number of <i>Hv</i> and <i>Hb</i> chromosomes, and the number of recombined <i>Hv</i> chromosomes of the hybrids strongly influenced the <i>Hv</i>-<i>Hb</i> pairing frequency in meiosis. Within the offspring of F<sub>2</sub> and F<sub>3</sub> hybrids both <i>Hv</i> plants and hybrids were detected. In contrast, all progenies of the F<sub>4</sub> hybrid were hybrids which exhibited centromere misdivisions. The highest frequencies of homoeologous pairing in hybrids and most recombinants were obtained for the barley chromosome 1HL. Recombinants for 4HL, 5HS, 6HS, and 7HS were rarely found. Meiotic pairing and recombinants involving chromosome 1HS were never observed. The results of this study demonstrate that fertile tetraploid interspecific hybrids with a high intergenomic pairing at meiosis are valuable basic material for introgression breeding in barley.
DOI: 10.6084/m9.figshare.4569742.v1
title: Supplementary Material for: The Effect of Homoeologous Meiotic Pairing in Tetraploid Hordeum bulbosum L. × H. vulgare L. Hybrids on Alien Introgressions in Offspring

description: The pairing behaviour of the individual chromosome arms of <i>Hordeum vulgare </i>(<i>Hv</i>) with their homoeologous arms of <i>H. bulbosum </i>(<i>Hb</i>) at metaphase I of meiosis in tetraploid <i>Hb </i>× <i>Hv </i>hybrids and the frequencies of recombined <i>Hv</i> chromosome arms in selfed offspring were studied on differentially visualized chromosomes after fluorescent in situ hybridisation. The frequencies of paired <i>Hv-Hb</i> arms in the F<sub>2</sub> and F<sub>3</sub> hybrids were correlated with the frequencies of recombined <i>Hv</i> chromosomes in progenies. Self-generation of hybrids, the number of <i>Hv</i> and <i>Hb</i> chromosomes, and the number of recombined <i>Hv</i> chromosomes of the hybrids strongly influenced the <i>Hv</i>-<i>Hb</i> pairing frequency in meiosis. Within the offspring of F<sub>2</sub> and F<sub>3</sub> hybrids both <i>Hv</i> plants and hybrids were detected. In contrast, all progenies of the F<sub>4</sub> hybrid were hybrids which exhibited centromere misdivisions. The highest frequencies of homoeologous pairing in hybrids and most recombinants were obtained for the barley chromosome 1HL. Recombinants for 4HL, 5HS, 6HS, and 7HS were rarely found. Meiotic pairing and recombinants involving chromosome 1HS were never observed. The results of this study demonstrate that fertile tetraploid interspecific hybrids with a high intergenomic pairing at meiosis are valuable basic material for introgression breeding in barley.
DOI: 10.6084/m9.figshare.4569736
title: First report of trunk rot caused by <i>Fomitiporia torreyae</i> in Kyoto prefecture on cultivars of Japanese cedar with no relatedness to ‘Sanbu-sugi’

description: Trunk rot, caused by <i>Fomitiporia torreyae</i>, is one of the most economically important sap rot diseases on <i>Cryptomeria japonica</i>, especially on a cutting cultivar ‘Sanbu-sugi’. This disease had been reported only from Chiba and Ibaraki prefectures in Japan; however, a similar trunk rot on Japanese cedars was found recently in Kyoto prefecture. We identified the causal agent of the trunk rot on Japanese cedars in Kyoto prefecture, clarified the genotype of ‘Sanbu-sugi’ (sensu stricto) using microsatellite markers, and then investigated the relatedness of these infected cedars with ‘Sanbu-sugi’. The pathogen was identified as <i>F. torreyae</i> by its DNA sequences and morphological characteristics of the fruiting body. The 25 ramets of ‘Sanbu-sugi’ had only one genotype based on eight microsatellite loci. Infected Japanese cedars in Kyoto were comprised of different genotypes and showed no close relatedness to ‘Sanbu-sugi’. This is the first report of trunk rot caused by <i>F. torreyae</i> on cultivars of Japanese cedar with no relatedness to ‘Sanbu-sugi’ outside of Chiba and Ibaraki prefectures and showed the potential for expansion of this disease to Japanese cedar plantations in other areas.
DOI: 10.6084/m9.figshare.4569736.v1
title: First report of trunk rot caused by <i>Fomitiporia torreyae</i> in Kyoto prefecture on cultivars of Japanese cedar with no relatedness to ‘Sanbu-sugi’

description: Trunk rot, caused by <i>Fomitiporia torreyae</i>, is one of the most economically important sap rot diseases on <i>Cryptomeria japonica</i>, especially on a cutting cultivar ‘Sanbu-sugi’. This disease had been reported only from Chiba and Ibaraki prefectures in Japan; however, a similar trunk rot on Japanese cedars was found recently in Kyoto prefecture. We identified the causal agent of the trunk rot on Japanese cedars in Kyoto prefecture, clarified the genotype of ‘Sanbu-sugi’ (sensu stricto) using microsatellite markers, and then investigated the relatedness of these infected cedars with ‘Sanbu-sugi’. The pathogen was identified as <i>F. torreyae</i> by its DNA sequences and morphological characteristics of the fruiting body. The 25 ramets of ‘Sanbu-sugi’ had only one genotype based on eight microsatellite loci. Infected Japanese cedars in Kyoto were comprised of different genotypes and showed no close relatedness to ‘Sanbu-sugi’. This is the first report of trunk rot caused by <i>F. torreyae</i> on cultivars of Japanese cedar with no relatedness to ‘Sanbu-sugi’ outside of Chiba and Ibaraki prefectures and showed the potential for expansion of this disease to Japanese cedar plantations in other areas.
DOI: 10.6084/m9.figshare.4569718
title: The populations and distribution of <i>Pieris japonica</i>, a poisonous tree protected from herbivore browsing pressure, increase slowly but steadily

description: <i>Pieris japonica</i> is a poisonous tree species that is rarely eaten by herbivorous animals, a fact that could enable the expansion of its distribution range and influence ecosystems into which it encroaches. In a regional-scale study, 300 <i>P. japonica</i> trees from 13 populations were sampled at the University of Tokyo Chichibu Forest, Japan, and were analyzed using 11 microsatellite markers. Genetic differentiation among the populations was low (<i>F</i><sub>ST</sub> = 0.022 and <i>G′</i><sub>ST</sub> = 0.024). A plot (30 × 30 m) was established for a fine-scale study, in which all <i>P. japonica</i> trees and saplings were measured and genetically analyzed using the microsatellite markers. Using this approach, we detected 84 genotypes among the 121 <i>P. japonica</i> trees in the plot. A few genotypes had expanded by more than 5 m, indicating that the ability to reproduce asexually could facilitate <i>P. japonica</i> trees to remain in a given location. Autocorrelation analysis showed that the extent of nonrandom spatial genetic structure was approximately 7.0 m, suggesting that seed dispersal was limited. KINGROUP analyses showed that 44 genotype pairs were full siblings, 23 were half-siblings, and 40 were parent-offspring. Only 32 seedlings were observed, of which 15 had reproduced asexually. The number of <i>P. japonica</i> trees has been increasing gradually for more than half a century in our study areas.
DOI: 10.6084/m9.figshare.4569718.v1
title: The populations and distribution of <i>Pieris japonica</i>, a poisonous tree protected from herbivore browsing pressure, increase slowly but steadily

description: <i>Pieris japonica</i> is a poisonous tree species that is rarely eaten by herbivorous animals, a fact that could enable the expansion of its distribution range and influence ecosystems into which it encroaches. In a regional-scale study, 300 <i>P. japonica</i> trees from 13 populations were sampled at the University of Tokyo Chichibu Forest, Japan, and were analyzed using 11 microsatellite markers. Genetic differentiation among the populations was low (<i>F</i><sub>ST</sub> = 0.022 and <i>G′</i><sub>ST</sub> = 0.024). A plot (30 × 30 m) was established for a fine-scale study, in which all <i>P. japonica</i> trees and saplings were measured and genetically analyzed using the microsatellite markers. Using this approach, we detected 84 genotypes among the 121 <i>P. japonica</i> trees in the plot. A few genotypes had expanded by more than 5 m, indicating that the ability to reproduce asexually could facilitate <i>P. japonica</i> trees to remain in a given location. Autocorrelation analysis showed that the extent of nonrandom spatial genetic structure was approximately 7.0 m, suggesting that seed dispersal was limited. KINGROUP analyses showed that 44 genotype pairs were full siblings, 23 were half-siblings, and 40 were parent-offspring. Only 32 seedlings were observed, of which 15 had reproduced asexually. The number of <i>P. japonica</i> trees has been increasing gradually for more than half a century in our study areas.
DOI: 10.6084/m9.figshare.4569682
title: Stacking faults and the gamma-surface on first-order pyramidal planes in alpha-titanium

description: We have computed the full first-order pyramidal gamma surface for alpha-Ti using density functional theory. We have found one low energy and one high energy stacking fault with differing degrees of stability. We do not find a stable stacking fault at (c+a)/2.This is supporting data for the work titled "Stacking faults and the γ-surface on first-order pyramidal planes in α-titanium". The work has been accepted by Philosophy Magazine for publication with the DOI: 10.1080/14786435.2017.1292059.
DOI: 10.6084/m9.figshare.4569682.v1
title: Stacking faults and the gamma-surface on first-order pyramidal planes in alpha-titanium

description: We have computed the full first-order pyramidal gamma surface for alpha-Ti using density functional theory. We have found one low energy and one high energy stacking fault with differing degrees of stability. We do not find a stable stacking fault at (c+a)/2.This is supporting data for the work titled "Stacking faults and the γ-surface on first-order pyramidal planes in α-titanium". The work has been accepted by Philosophy Magazine for publication with the DOI: 10.1080/14786435.2017.1292059.
DOI: 10.6084/m9.figshare.4569673
title: Biogeographic scenarios for the diversification of a widespread Neotropical species, <i>Glossophaga soricina</i> (Chiroptera: Phyllostomidae)

description: In order to contribute to the understanding of the effect of geological and climatic changes on species diversification in the Neotropics, we employed molecular techniques to study the population dynamics of the glossophagine bat <i>Glossophaga soricina</i>, a widespread species in the Neotropical region. We aimed to assess the dispersal and distribution of mtDNA lineages of <i>G. soricina</i> and evaluate the possible effect of vicariant events in the population history and dynamics. <i>Glossophaga soricina</i> presented two main highly supported mtDNA lineages, which diverged between ∼2.4 and 5 million years ago, probably following a vicariant event caused by the Andes final uplift. The lower sea level during Pleistocene glaciations also made possible the occupation of Jamaica after an event of dispersion over the Caribbean Sea, although past climatic fluctuations had little effect over population dynamics of <i>G. soricina</i>. Our results corroborate the idea that the Andes uplift played an important role in the evolution of Neotropical biodiversity. In this context we suggest that geographic events causing large scale environmental disjunction, such as the uplift of mountains, are more likely to restrict gene flow amongst populations of tolerant species with broad geographic range than local climate driven environmental changes.