cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3466739
title: Supplementary Material for: Progressive Resistance Training in End-Stage Renal Disease: Systematic Review

description: <b><i>Background:</i></b> This systematic review provides an overview of the extant literature on progressive resistance training (PRT) in patients with end-stage renal disease (ESRD) and outlines recommendations for future trials. <b><i>Methods:</i></b> A systematic review of all published literature evaluating the chronic (&gt;6 weeks) application of PRT in patients with ESRD using electronic databases. <b><i>Results:</i></b> The search yielded 16 clinical trials, including 11 randomized controlled trials (RCT), 4 uncontrolled trials and one trial involving a within-subjects control period plus RCT. RCT quality, assessed via the CONSORT statement, ranged from low (4/10) to high (10/10) with a mean score of 7.3/10; 7/11 RCT had a quality score ≥7.5. All trials evaluated chronic adaptation to PRT across a range of important outcomes. PRT can induce muscle hypertrophy and improve aspects of physical functioning and health-related quality of life in ESRD. There is preliminary evidence that PRT may reduce protein-energy malnutrition and cardiovascular disease risk factors, including C-reactive protein, total cholesterol, triglyceride, and measures of insulin resistance in patients with or at-risk of comorbid type 2 diabetes. The evidence base for PRT adapting some of the endpoints investigated to date remains inconsistent (e.g. physical performance tests, obesity outcomes), and many other pertinent clinical outcomes remain to be investigated. <b><i>Conclusion:</i></b> RCT are required to investigate a range of novel research questions related to the benefits and application of PRT in this cohort and its patient subgroups (e.g. diabetes, depression, dyslipidemia, etc.). Future studies must be of high methodological quality to inform clinical practice guidelines.
DOI: 10.6084/m9.figshare.3466739.v1
title: Supplementary Material for: Progressive Resistance Training in End-Stage Renal Disease: Systematic Review

description: <b><i>Background:</i></b> This systematic review provides an overview of the extant literature on progressive resistance training (PRT) in patients with end-stage renal disease (ESRD) and outlines recommendations for future trials. <b><i>Methods:</i></b> A systematic review of all published literature evaluating the chronic (&gt;6 weeks) application of PRT in patients with ESRD using electronic databases. <b><i>Results:</i></b> The search yielded 16 clinical trials, including 11 randomized controlled trials (RCT), 4 uncontrolled trials and one trial involving a within-subjects control period plus RCT. RCT quality, assessed via the CONSORT statement, ranged from low (4/10) to high (10/10) with a mean score of 7.3/10; 7/11 RCT had a quality score ≥7.5. All trials evaluated chronic adaptation to PRT across a range of important outcomes. PRT can induce muscle hypertrophy and improve aspects of physical functioning and health-related quality of life in ESRD. There is preliminary evidence that PRT may reduce protein-energy malnutrition and cardiovascular disease risk factors, including C-reactive protein, total cholesterol, triglyceride, and measures of insulin resistance in patients with or at-risk of comorbid type 2 diabetes. The evidence base for PRT adapting some of the endpoints investigated to date remains inconsistent (e.g. physical performance tests, obesity outcomes), and many other pertinent clinical outcomes remain to be investigated. <b><i>Conclusion:</i></b> RCT are required to investigate a range of novel research questions related to the benefits and application of PRT in this cohort and its patient subgroups (e.g. diabetes, depression, dyslipidemia, etc.). Future studies must be of high methodological quality to inform clinical practice guidelines.
DOI: 10.6084/m9.figshare.3466691
title: Supplementary Material for: 1,2,4,5-Tetramethoxybenzene Suppresses House Dust Mite-Induced Allergic Inflammation in BALB/c Mice

description: <b><i>Background:</i></b> Atopic dermatitis (AD) is the most common allergic inflammatory skin disease. The activation of innate immunity by house dust mite (<i>Dermatophagoides farinae </i>extract, DFE) allergen plays an important role in the pathogenesis of AD. We previously showed the inhibitory effect of an extract of <i>Amomum xanthioides</i> on allergic diseases, and isolated 1,2,4,5-tetramethoxybenzene (TMB) as a major active component. In this study, we investigated whether TMB relieves DFE-induced allergic inflammation symptoms. <b><i>Methods:</i></b> We established a DFE-induced allergic inflammation model in BALB/c mice by repeated skin exposure to DFE. To define the underlying mechanisms of action, we used a tumor necrosis factor-α and interferon-γ-activated human keratinocytes (HaCaT cell line) and mouse keratinocytes (3PC cell line) cell line model. <b><i>Results:</i></b> Oral administration of TMB suppressed allergic inflammation symptoms, such as histopathological analysis and ear thickness, in addition to serum IgE, DFE-specific IgE and IgG2a levels. TMB decreased the serum histamine levels and tissue infiltration of inflammatory cells, including mast cells and eosinophils. TMB also inhibited CD4<sup>+</sup>IFN-γ<sup>+</sup>, CD4<sup>+</sup>IL-4<sup>+</sup>, and CD4<sup>+</sup>IL-17A<sup>+</sup> lymphocyte expansion in the draining lymph nodes and expression of the Th2 cytokines in the ear tissue. TMB significantly inhibited the expression of cytokines and chemokines by the downregulation of the mitogen-activated protein kinases and nuclear factor of activated cytoplasmic T cells in HaCaT cells. <b><i>Conclusions:</i></b> TMB improved DFE-induced allergic inflammation by suppressing the production of proinflammatory cytokines and chemokines. Our results suggest that TMB might be a potential therapeutic agent for AD.
DOI: 10.6084/m9.figshare.3466691.v1
title: Supplementary Material for: 1,2,4,5-Tetramethoxybenzene Suppresses House Dust Mite-Induced Allergic Inflammation in BALB/c Mice

description: <b><i>Background:</i></b> Atopic dermatitis (AD) is the most common allergic inflammatory skin disease. The activation of innate immunity by house dust mite (<i>Dermatophagoides farinae </i>extract, DFE) allergen plays an important role in the pathogenesis of AD. We previously showed the inhibitory effect of an extract of <i>Amomum xanthioides</i> on allergic diseases, and isolated 1,2,4,5-tetramethoxybenzene (TMB) as a major active component. In this study, we investigated whether TMB relieves DFE-induced allergic inflammation symptoms. <b><i>Methods:</i></b> We established a DFE-induced allergic inflammation model in BALB/c mice by repeated skin exposure to DFE. To define the underlying mechanisms of action, we used a tumor necrosis factor-α and interferon-γ-activated human keratinocytes (HaCaT cell line) and mouse keratinocytes (3PC cell line) cell line model. <b><i>Results:</i></b> Oral administration of TMB suppressed allergic inflammation symptoms, such as histopathological analysis and ear thickness, in addition to serum IgE, DFE-specific IgE and IgG2a levels. TMB decreased the serum histamine levels and tissue infiltration of inflammatory cells, including mast cells and eosinophils. TMB also inhibited CD4<sup>+</sup>IFN-γ<sup>+</sup>, CD4<sup>+</sup>IL-4<sup>+</sup>, and CD4<sup>+</sup>IL-17A<sup>+</sup> lymphocyte expansion in the draining lymph nodes and expression of the Th2 cytokines in the ear tissue. TMB significantly inhibited the expression of cytokines and chemokines by the downregulation of the mitogen-activated protein kinases and nuclear factor of activated cytoplasmic T cells in HaCaT cells. <b><i>Conclusions:</i></b> TMB improved DFE-induced allergic inflammation by suppressing the production of proinflammatory cytokines and chemokines. Our results suggest that TMB might be a potential therapeutic agent for AD.
DOI: 10.6084/m9.figshare.3466679
title: Supplementary Material for: Chorioamnionitis and Five-Year Neurodevelopmental Outcome in Preterm Infants

description: <b><i>Background:</i></b> Chorioamnionitis, a risk factor for preterm delivery, has been suggested to be associated with suboptimal neurological development in premature infants. <b><i>Objective:</i></b> To evaluate the association between chorioamnionitis and neurodevelopment in preterm infants at 5 years of age. <b><i>Methods </i></b>Very low birth weight and very low gestational age infants (n = 197) were recruited. Placental samples (n = 117) were evaluated for histological chorioamnionitis. Fetal histological chorioamnionitis was analyzed as a subgroup. The diagnosis of clinical chorioamnionitis was derived from medical records. Neurodevelopmental impairments were evaluated at 2 years of age, and cognitive development (n = 188) and neuropsychological performance (n = 193) were evaluated at 5 years of age. <b><i>Results:</i></b> There were no associations between histological or clinical chorioamnionitis and neurodevelopmental impairments at 2 years of age.<b> </b>Clinical chorioamnionitis and fetal histological chorioamnionitis were not associated with cognitive development or neuropsychological performance, but histological chorioamnionitis was associated with poorer cognitive outcome (regression coefficient = -7.22, 95% CI: -14.31 to -0.13) and weaker memory and learning functions (regression coefficient = -1.29, 95% CI: -2.40 to -0.18) at 5 years of age. <b><i>Conclusion:</i></b> Our study findings do not support clinical chorioamnionitis having a major independent role in the pathogenesis of neurodevelopmental problems in very preterm infants. Histological chorioamnionitis was associated with slightly less optimal performance at 5 years of age, but further studies are needed to verify the clinical significance of these findings.
DOI: 10.6084/m9.figshare.3466679.v1
title: Supplementary Material for: Chorioamnionitis and Five-Year Neurodevelopmental Outcome in Preterm Infants

description: <b><i>Background:</i></b> Chorioamnionitis, a risk factor for preterm delivery, has been suggested to be associated with suboptimal neurological development in premature infants. <b><i>Objective:</i></b> To evaluate the association between chorioamnionitis and neurodevelopment in preterm infants at 5 years of age. <b><i>Methods </i></b>Very low birth weight and very low gestational age infants (n = 197) were recruited. Placental samples (n = 117) were evaluated for histological chorioamnionitis. Fetal histological chorioamnionitis was analyzed as a subgroup. The diagnosis of clinical chorioamnionitis was derived from medical records. Neurodevelopmental impairments were evaluated at 2 years of age, and cognitive development (n = 188) and neuropsychological performance (n = 193) were evaluated at 5 years of age. <b><i>Results:</i></b> There were no associations between histological or clinical chorioamnionitis and neurodevelopmental impairments at 2 years of age.<b> </b>Clinical chorioamnionitis and fetal histological chorioamnionitis were not associated with cognitive development or neuropsychological performance, but histological chorioamnionitis was associated with poorer cognitive outcome (regression coefficient = -7.22, 95% CI: -14.31 to -0.13) and weaker memory and learning functions (regression coefficient = -1.29, 95% CI: -2.40 to -0.18) at 5 years of age. <b><i>Conclusion:</i></b> Our study findings do not support clinical chorioamnionitis having a major independent role in the pathogenesis of neurodevelopmental problems in very preterm infants. Histological chorioamnionitis was associated with slightly less optimal performance at 5 years of age, but further studies are needed to verify the clinical significance of these findings.
DOI: 10.6084/m9.figshare.3466652
title: Chemical and <i>in vitro</i> biological information to predict mouse liver toxicity using recursive random forests

description: In this study, recursive random forests were used to build classification models for mouse liver toxicity. The mouse liver toxicity endpoint (67 toxic and 166 non-toxic) was a composition of four <i>in vivo</i> chronic systemic and carcinogenic toxicity endpoints (non-proliferative, neoplastic, proliferative and gross pathology). A multiple under-sampling approach and a shifted classification threshold of 0.288 (non-toxic &lt; 0.288 and toxic ≥ 0.288) were used to cope with the unbalanced data. Our study showed that recursive random forests are very efficient in variable selection and for the development of predictive <i>in silico</i> models. Generally, over 95% redundant descriptors could be reduced from modelling for all the chemical, biological and hybrid models in this study. The predictive performance of chemical models (CCR of 0.73) is comparable with hybrid model performance (CCR of 0.74). Descriptors related to the octanol–water partition coefficient are vital for model performance. The <i>in vitro</i> endpoint of CYP2A2 played a key role in the development and interpretation of hybrid models. Identifying high-throughput screening assays relevant to liver toxicity would be key for improving <i>in silico</i> models of liver toxicity.
DOI: 10.6084/m9.figshare.3466652.v1
title: Chemical and <i>in vitro</i> biological information to predict mouse liver toxicity using recursive random forests

description: In this study, recursive random forests were used to build classification models for mouse liver toxicity. The mouse liver toxicity endpoint (67 toxic and 166 non-toxic) was a composition of four <i>in vivo</i> chronic systemic and carcinogenic toxicity endpoints (non-proliferative, neoplastic, proliferative and gross pathology). A multiple under-sampling approach and a shifted classification threshold of 0.288 (non-toxic &lt; 0.288 and toxic ≥ 0.288) were used to cope with the unbalanced data. Our study showed that recursive random forests are very efficient in variable selection and for the development of predictive <i>in silico</i> models. Generally, over 95% redundant descriptors could be reduced from modelling for all the chemical, biological and hybrid models in this study. The predictive performance of chemical models (CCR of 0.73) is comparable with hybrid model performance (CCR of 0.74). Descriptors related to the octanol–water partition coefficient are vital for model performance. The <i>in vitro</i> endpoint of CYP2A2 played a key role in the development and interpretation of hybrid models. Identifying high-throughput screening assays relevant to liver toxicity would be key for improving <i>in silico</i> models of liver toxicity.
DOI: 10.6084/m9.figshare.3466649.v2
title: Borders of a Human Being

description: <br>Informatics in technical reality is coming nearer and nearer to the “biological” human being.<br>It seems to be necessary to protect humans against excessive demands by hardware of<br>Cyber world and especially against computers as machines and their software.<br>The human being as evolutional species on one side is measured in a very long development<br>time of thousands of years, the IT on the other side works with human creativity and in<br>much faster time intervals of some years or - maximal - decenniums only. These times show<br>a big difference in both areas. The execution-times of the biological human being and his<br>general surroundings on one hand and the IT with her applications – in electronic speeds -<br>on the other hand are an outstanding conflict of time. Humans don’t act like computers!<br>The structure of this work is given by the biological organism, but also the thinking and<br>feeling of a human being. He has senses, instruments for movement and mental abilities as a<br>whole. The human being in nature science is a biological object and in the human society an<br>individual subject with own self awareness und personal intelligence. Compared with all living<br>subjects he has the highest developed consciousness of his own person. The modern science<br>seems to make them unimportant.<br>The goal of this work is, to find the biological a n d psychological borders of the human<br>being and protect him in a preventive medical kind against coming dangers like for inst. bad<br>stress and following sickness. Theoretical Informatics has to find out principles, rules and<br>ways of thinking for human-orientated IT to avoid this danger.<br>There is no demand on finding out all at once but a beginning on a scientific level is intended.<br>This work is thought as the first foundation and compendium for all main themes of HO<br>(Human Orientation).<br>Besides a speciality out of biology is described new - The Rules of Mendel, a biological<br>stimulus for informatics.<br>
DOI: 10.6084/m9.figshare.3466643
title: Predicting white peach scale phenology on kiwifruit in Sichuan

description: White peach scale (<i>Pseudaulacaspis pentagona</i>) is a polyphagous pest of perennial horticulture in Asia and many other warm-temperate and tropical regions. In China, it is a serious pest of kiwifruit. The optimal time to control <i>P. pentagona</i> field populations is at the first instar stage of the first, spring generation. Three methods for predicting the hatching of eggs of the first generation from field populations were tested on kiwifruit in Sichuan, based upon the accumulation of heat units (day-degrees) above a developmental threshold, calculated as 10.75 °C. A method developed for <i>P. pentagona</i> control in tea in Japan gave excellent predictions of 50% hatching in 5 of the 6 years under study (2009–2014). The other two methods also gave acceptable predictions of dates of 50% egg hatching (within 5 days of field observed dates). These models may be used as a basis for forecasting spring insecticide application dates targeting the first instar stage (crawlers and settled ‘white caps’).
DOI: 10.6084/m9.figshare.3466643.v1
title: Predicting white peach scale phenology on kiwifruit in Sichuan

description: White peach scale (<i>Pseudaulacaspis pentagona</i>) is a polyphagous pest of perennial horticulture in Asia and many other warm-temperate and tropical regions. In China, it is a serious pest of kiwifruit. The optimal time to control <i>P. pentagona</i> field populations is at the first instar stage of the first, spring generation. Three methods for predicting the hatching of eggs of the first generation from field populations were tested on kiwifruit in Sichuan, based upon the accumulation of heat units (day-degrees) above a developmental threshold, calculated as 10.75 °C. A method developed for <i>P. pentagona</i> control in tea in Japan gave excellent predictions of 50% hatching in 5 of the 6 years under study (2009–2014). The other two methods also gave acceptable predictions of dates of 50% egg hatching (within 5 days of field observed dates). These models may be used as a basis for forecasting spring insecticide application dates targeting the first instar stage (crawlers and settled ‘white caps’).
DOI: 10.6084/m9.figshare.3466631
title: World-wide architecture of osteoporosis research: density-equalizing mapping studies and gender analysis

description: <b>Objective:</b> While research activities on osteoporosis grow constantly, no concise description of the global research architecture exists. Hence, we aim to analyze and depict the world-wide scientific output on osteoporosis combining bibliometric tools, density-equalizing mapping projections and gender analysis. <b>Method:</b> Using the NewQIS platform, we analyzed all osteoporosis-related publications authored from 1900 to 2012 and indexed by the Web of Science. Bibliometric details were analyzed related to quantitative and semi-qualitative aspects. <b>Results:</b> The majority of 57 453 identified publications were original research articles. The USA and Western Europe dominated the field regarding cooperation activity, publication and citation performance. Asia, Africa and South America played a minimal role. Gender analysis revealed a dominance of male scientists in almost all countries except Brazil. <b>Conclusion:</b> Although the scientific performance on osteoporosis is increasing world-wide, a significant disparity in terms of research output was visible between developed and low-income countries. This finding is particularly concerning since epidemiologic evaluations of future osteoporosis prevalences predict enormous challenges for the health-care systems in low-resource countries. Hence, our study underscores the need to address these disparities by fostering future research endeavors in these nations with the aim to successfully prevent a growing global burden related to osteoporosis.
DOI: 10.6084/m9.figshare.3466631.v1
title: World-wide architecture of osteoporosis research: density-equalizing mapping studies and gender analysis

description: <b>Objective:</b> While research activities on osteoporosis grow constantly, no concise description of the global research architecture exists. Hence, we aim to analyze and depict the world-wide scientific output on osteoporosis combining bibliometric tools, density-equalizing mapping projections and gender analysis. <b>Method:</b> Using the NewQIS platform, we analyzed all osteoporosis-related publications authored from 1900 to 2012 and indexed by the Web of Science. Bibliometric details were analyzed related to quantitative and semi-qualitative aspects. <b>Results:</b> The majority of 57 453 identified publications were original research articles. The USA and Western Europe dominated the field regarding cooperation activity, publication and citation performance. Asia, Africa and South America played a minimal role. Gender analysis revealed a dominance of male scientists in almost all countries except Brazil. <b>Conclusion:</b> Although the scientific performance on osteoporosis is increasing world-wide, a significant disparity in terms of research output was visible between developed and low-income countries. This finding is particularly concerning since epidemiologic evaluations of future osteoporosis prevalences predict enormous challenges for the health-care systems in low-resource countries. Hence, our study underscores the need to address these disparities by fostering future research endeavors in these nations with the aim to successfully prevent a growing global burden related to osteoporosis.