cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30498884
title: Supplementary Material for: Pustular Vasculitis of the Lower Limbs with Diarrhea and Arthritis: A Case Report

description: Introduction: Pustular vasculitis is a rare skin disease with only a few reported cases worldwide, especially when the lesions occur on the lower limbs. This report presents a rare case of pustular vasculitis on both lower limbs, and good therapeutic effects were achieved after our treatment. Case Presentation: We report a case of an 86-year-old female who presented with annular erythema, purpura, and pustules on both lower limbs. Skin biopsies showed neutrophilic infiltration and leukocytoclastic vasculitis changes. She had a history of chronic diarrhea for the past two years. X-ray of both hands revealed osteoarthritis of multiple interphalangeal joints. After treatment with systemic methylprednisolone, minocycline and tripterygium glycosides for anti-inflammation, the lesions were significantly relieved. Conclusion: We report this case because of its rarity and remind physicians to keep in mind of the possibility of pustular vasculitis while dealing with lesions of extensive annular haemorrhagic spots with pustules, along with diarrhea and arthritis.
DOI: 10.6084/m9.figshare.30498884.v1
title: Supplementary Material for: Pustular Vasculitis of the Lower Limbs with Diarrhea and Arthritis: A Case Report

description: Introduction: Pustular vasculitis is a rare skin disease with only a few reported cases worldwide, especially when the lesions occur on the lower limbs. This report presents a rare case of pustular vasculitis on both lower limbs, and good therapeutic effects were achieved after our treatment. Case Presentation: We report a case of an 86-year-old female who presented with annular erythema, purpura, and pustules on both lower limbs. Skin biopsies showed neutrophilic infiltration and leukocytoclastic vasculitis changes. She had a history of chronic diarrhea for the past two years. X-ray of both hands revealed osteoarthritis of multiple interphalangeal joints. After treatment with systemic methylprednisolone, minocycline and tripterygium glycosides for anti-inflammation, the lesions were significantly relieved. Conclusion: We report this case because of its rarity and remind physicians to keep in mind of the possibility of pustular vasculitis while dealing with lesions of extensive annular haemorrhagic spots with pustules, along with diarrhea and arthritis.
DOI: 10.6084/m9.figshare.30498887
title: Supplementary Material for: UK Medical Cannabis Registry: An Updated Analysis of Cannabis-Based Medicinal Products for Multiple Sclerosis

description: Introduction
Multiple sclerosis (MS) is a neurodegenerative disease presenting with a wide range of motor, sensory and psychiatric symptoms. Although nabiximols is licensed for MS-induced spasticity, cannabis-based medicinal products (CBMPs) have also displayed promising therapeutic potential for managing pain, sleep and anxiety. Therefore, further evaluation of CBMP treatment for MS is warranted. This study aimed to assess the efficacy and tolerability of CBMP treatment in patients with MS by investigating changes in MS-specific and general health-related patient-reported outcome measures and adverse events. 

Methods
This was a prospective case series including patients with MS enrolled on the United Kingdom Medical Cannabis Registry. Changes in MS Quality of Life-54 (MSQOL-54), Generalised Anxiety Disorder-7 (GAD-7), Single-Item Sleep Quality Scale (SQS), and EQ-5D-5L scores were assessed from baseline up to 24 months. The prevalence and severity of all adverse events were also assessed. 

Results
This study included 203 patients, of whom 47.29% (n=96)were female and 80.79% (n=164)had prior cannabis exposure. Improvements in the MSQOL-54 subscales: change in health, energy, health distress, pain, physical function, and physical role limitations, along with improvements in SQS and EQ-5D-5L scores, were seen at all follow-up times compared to baseline (p&lt;0.050). A total of 278 adverse events were reported by 26 patients (12.81%). Most adverse events were mild (n=91, 32.73%) or moderate (n=138, 49.64%) in severity, with fatigue (n=27, 13.30%) and spasticity (n=17, 8.37%) being the most common.

Conclusion
CBMP treatment over 24 months was associated with improvements in health-related quality of life and was well-tolerated in patients with MS. Future randomised controlled trials with more representative study populations are needed to establish causal relationships.
DOI: 10.6084/m9.figshare.30498887.v1
title: Supplementary Material for: UK Medical Cannabis Registry: An Updated Analysis of Cannabis-Based Medicinal Products for Multiple Sclerosis

description: Introduction
Multiple sclerosis (MS) is a neurodegenerative disease presenting with a wide range of motor, sensory and psychiatric symptoms. Although nabiximols is licensed for MS-induced spasticity, cannabis-based medicinal products (CBMPs) have also displayed promising therapeutic potential for managing pain, sleep and anxiety. Therefore, further evaluation of CBMP treatment for MS is warranted. This study aimed to assess the efficacy and tolerability of CBMP treatment in patients with MS by investigating changes in MS-specific and general health-related patient-reported outcome measures and adverse events. 

Methods
This was a prospective case series including patients with MS enrolled on the United Kingdom Medical Cannabis Registry. Changes in MS Quality of Life-54 (MSQOL-54), Generalised Anxiety Disorder-7 (GAD-7), Single-Item Sleep Quality Scale (SQS), and EQ-5D-5L scores were assessed from baseline up to 24 months. The prevalence and severity of all adverse events were also assessed. 

Results
This study included 203 patients, of whom 47.29% (n=96)were female and 80.79% (n=164)had prior cannabis exposure. Improvements in the MSQOL-54 subscales: change in health, energy, health distress, pain, physical function, and physical role limitations, along with improvements in SQS and EQ-5D-5L scores, were seen at all follow-up times compared to baseline (p&lt;0.050). A total of 278 adverse events were reported by 26 patients (12.81%). Most adverse events were mild (n=91, 32.73%) or moderate (n=138, 49.64%) in severity, with fatigue (n=27, 13.30%) and spasticity (n=17, 8.37%) being the most common.

Conclusion
CBMP treatment over 24 months was associated with improvements in health-related quality of life and was well-tolerated in patients with MS. Future randomised controlled trials with more representative study populations are needed to establish causal relationships.
DOI: 10.5281/zenodo.17491584
title: 01-Peer_Ostracism-Emotional_Exhaustion-Turnover_Intention
DOI: 10.6075/j0ks6qb3
title: CIL:10769, Myotis lucifugus, acinar cell. In Cell Image Library

description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
description: Figure 171 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of rough endoplasmic reticulum (RER) in two adjacent acinar cells from the pancreas of the small brown bat, Myotis lucifugus. The surface membranes for the two cells are closely apposed and slightly thicker than the membranes associated with the ER. While free ribosomes are apparent between the plasma membrane and the ER, the ribosomes are separated from the inner border of the plasma membrane by about 10 nm (arrows). In contrast, the membrane associated with the ER is studded with adherent ribosomes. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
DOI: 10.6075/j0dv1hqs
title: CIL:10767, Homo sapiens, acinar cell. In Cell Image Library

description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
description: Figure 170 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of rough endoplasmic reticulum (RER) in an acinar cell from the human pancreas. The RER is stacked in a cisternal structure, and studded with ribosomes. In this particular preparation, fixation conditions were modified to preserve a flocculent precipitate of newly synthesized protein in the lumen of the ER. The nucleus of the cell is in the upper right corner. Micrograph by Susmo Ito and Arthur Like. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
DOI: 10.5281/zenodo.17491583
title: 01-Peer_Ostracism-Emotional_Exhaustion-Turnover_Intention
DOI: 10.6075/j0w094rf
title: CIL:10794, Phodopus, hepatocyte. In Cell Image Library

description: Figure 182 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of liver from a hamster treated with phenobarbitol for four days. Chronic exposure to the drug caused hypertrophy of the smooth endoplasmic reticulum, which now occupies nearly all of the space in the cytoplasm. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
DOI: 10.6075/j04x56k0
title: CIL:10793, Rattus, hepatocyte. In Cell Image Library

description: Figure 181 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of rat liver shows the accumulation of low density lipoprotein particles in the lumen of the smooth reticulum. Image by Robert Bolender. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
DOI: 10.15468/dl.udpdgk
title: Occurrence Download

description: A dataset containing 1582 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "TaxonKey is Passer montanus",
 "Year 2025-2025"
 ]
}

 The dataset includes 1582 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009497-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6075/j0765d5s
title: CIL:10790, Rattus, brush border epithelial cell. In Cell Image Library

description: Figure 180 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of a rat intestinal epithelium cell during absorption of a fatty meal. Droplets of lipid accumulate in the lumen of the smooth endoplasmic reticulum (arrows). Image by Sanford Palay. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
DOI: 10.6075/j0bz659k
title: CIL:1079, Caenorhabditis elegans, muscle cell. In Cell Image Library

description: Relation to intact cell: whole mounted tissue
Item type: recorded image
Imaging mode: fluorescence microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Visualization methods: phalloidin
Processing history: unprocessed raw data
description: C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). Note that the data sets for each age can be found by searching for a featured image from each set: CIL 1005, 1057, 1105, and 1265, respectively.
description: The purpose of the dataset C. elegans muscle aging is to deduce the age of the nemathode based on images of muscles. Images of C. elegans were taken at different chronological ages. This image is part of the day 2 data set. Note that the morphological and chronological ages are not fully correlated due to the variability among individuals even though the individuals are genetically identical. The source for the dataset is Laboratory of Genetics/NIA/NIH.
DOI: 10.6075/j0cf9pcz
title: CIL:1078, Caenorhabditis elegans, muscle cell. In Cell Image Library

description: C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). Note that the data sets for each age can be found by searching for a featured image from each set: CIL 1005, 1057, 1105, and 1265, respectively.
description: Relation to intact cell: whole mounted tissue
Item type: recorded image
Imaging mode: fluorescence microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Visualization methods: phalloidin
Processing history: unprocessed raw data
description: The purpose of the dataset C. elegans muscle aging is to deduce the age of the nemathode based on images of muscles. Images of C. elegans were taken at different chronological ages. This image is part of the day 2 data set. Note that the morphological and chronological ages are not fully correlated due to the variability among individuals even though the individuals are genetically identical. The source for the dataset is Laboratory of Genetics/NIA/NIH.
DOI: 10.6075/j05q4twb
title: CIL:10788. In Cell Image Library

description: Figure 179 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph showing a portion of the cytoplasm of a liver cell. The upper left part of the micrograph shows a network of branching and anastomosing smooth tubules that appear to connect with the cisternae of the rough endoplasmic reticulum (points of interconnection indicated by arrows). Image by Robert Bolander. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
DOI: 10.6075/j0c24v63
title: CIL:10775, Cavia porcellus, plasma cell. In Cell Image Library

description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
description: Figure 176 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of a plasma cell from guinea pig bone marrow. Active synthesis of immunoglobulin by this cell is associated the extensive rough endoplasmic reticulum (RER); the protein produced by the RER is stored in the cisternae, rather than in secretory granules, and is apparent in this micrograph in the distended labyrinthine network of cisternae. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
DOI: 10.6075/j0g44p39
title: CIL:10796, Phodopus, hepatocyte. In Cell Image Library

description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
description: Figure 183 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Electron micrograph of an hepatic liver cell from the hamster. The area of the cell shown is dense with smooth endoplasmic reticulum, and with glycogen in the interstitial spaces. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
DOI: 10.15468/dl.req6qf
title: Occurrence Download

description: A dataset containing 218 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Isatis platyloba"
 ]
}

 The dataset includes 218 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009498-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6075/j0fq9vdv
title: CIL:10815, Mus musculus, skeletal muscle cell. In Cell Image Library

description: Preparation: glutaraldehyde fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity; osmium tetroxide
Data qualification: Processed
description: Figure 195 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Selective staining of tubular invaginations of the sarcolemma in the tibialis anterior of the mouse. Following fixation by glutaraldehyde solution containing calcium, the tissue was post-fixed with osmium ferrocyanide, resulting in staining of the T-tubules and sacrotubules of the reticulum. The adjacent terminal cisternae and longitudinal sarcotubules are lightly stained. Image by Michael Forbes. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
DOI: 10.6075/j0rn3736
title: CIL:1081, Caenorhabditis elegans, muscle cell. In Cell Image Library

description: Relation to intact cell: whole mounted tissue
Item type: recorded image
Imaging mode: fluorescence microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Visualization methods: phalloidin
Processing history: unprocessed raw data
description: The purpose of the dataset C. elegans muscle aging is to deduce the age of the nemathode based on images of muscles. Images of C. elegans were taken at different chronological ages. This image is part of the day 2 data set. Note that the morphological and chronological ages are not fully correlated due to the variability among individuals even though the individuals are genetically identical. The source for the dataset is Laboratory of Genetics/NIA/NIH.
description: C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). Note that the data sets for each age can be found by searching for a featured image from each set: CIL 1005, 1057, 1105, and 1265, respectively.
DOI: 10.6075/j0vh5mn7
title: CIL:10809, Anura, skeletal muscle cell. In Cell Image Library

description: Figure 191 from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. A thin section through frog sartorius muscle shows the organization of the sarcoplasmic reticulum in amphibians. The components of the reticulum are evident in the verticle strip in the center of the micrograph; the two flanking strips are myofibrils. The myofibril on the right is slightly out of register for technical reasons. Image by Lee Peachy. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
DOI: 10.6075/j0rv0mgm
title: CIL:10797, Oryctolagus, muscle cell. In Cell Image Library

description: Preparation: crosslinking-fixative fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Data qualification: Processed
description: Figures 184 (upper left), 185 (upper right), and 186 (lower) from Chapter 5 (Endoplasmic Reticulum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Sarcoplasmic reticulum of the extraocular muscles of the rabbit, arranged in concentric, or sprialing cisternae. In the upper left panel, dark packages of glycogen are interspersed throughout the cisternae, whereas in they accumulate most densely at the edges of the sacroplasm in the images in the upper right and lower panels. Images by J. Davidowitz; Fig. 185 from Am. J. Pathol. 78:191, 1975 and Proc. Electron Society of America, 1976. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.
DOI: 10.6075/j00r9nqq
title: CIL:1075, Caenorhabditis elegans, muscle cell. In Cell Image Library

description: C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). Note that the data sets for each age can be found by searching for a featured image from each set: CIL 1005, 1057, 1105, and 1265, respectively.
description: The purpose of the dataset C. elegans muscle aging is to deduce the age of the nemathode based on images of muscles. Images of C. elegans were taken at different chronological ages. This image is part of the day 2 data set. Note that the morphological and chronological ages are not fully correlated due to the variability among individuals even though the individuals are genetically identical. The source for the dataset is Laboratory of Genetics/NIA/NIH.
description: Relation to intact cell: whole mounted tissue
Item type: recorded image
Imaging mode: fluorescence microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Visualization methods: phalloidin
Processing history: unprocessed raw data