cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.581418
title: Level A Pan Europe Land-Use, E-Hype 2.5

description: Land use is given as the percentage of one of 9 land use classes within a subbasin (i.e. subbasin level). The classes are Water, Glacier/Snow, Urban area, Forest, Agricultural land, Other and &gt; 500 m, Wetland, Tundra/Permafrost, Extensive grassland/pasture. This is also given as percentage of each land use class upstream of (and including) a subbasin (i.e. catchment level, mean area 215 km2). Original data source: CORINE Land Cover (CLC2000), GLC2000 Northern Eurasia v4.0, GLC2000 Asia v1.0, GLC2000 Europe v2.0, Euroland SoilSealing 2009. Tools for repurposing: WHIST. Data format: Table (Excel file) with unique subID which could be linked to the shapefile EHYPE_polygons_v2pt5.shp.
DOI: 10.5281/zenodo.581419
title: Level A Pan Europe Locations Observation Stations, E-Hype 2.5

description: Shapefile showing the positions of gauging stations adjusted to the delineation and routing of E-HYPEv2.5 Original data source: GRDC-Europe, EWA stations, ES, baltex_stns, EWA. Tools for repurposing: WHIST. Spatial resolution: Locations. Data format: Shapefile containing the following information: SUBID Subbasin where station is positioned; DATA_SOURC=Original data source from where observations can be ordered; STATION_NO= ID of the gauging station; STATION=Name of station; X_EHYPEv2.5= x coordinate in decimal degrees adjusted for E-HYPEv2.5 delineation and routing; Y_EHYPEv2.5= y coordinate in decimal degrees adjusted for E-HYPEv2.5 delineation and routing. The dataset, Subbasin(EHYPE2pt5).zip (shapefile with subbasin polygons) can be linked with the data.
DOI: 10.5281/zenodo.581648
title: Led Dataset

description: Live Editor for DOM.<br>
Web applications evolve over time, the DOM element locators used today may not be prevalent in the future. This may affect the selector coverage<br>
and accuracy results for LED. Therefore, They have made the analyzed dataset publicly available
DOI: 10.18462/iir.cals.2016.26
title: The cryopreservation of mice skins for 5 weeks at -20°C and of human skin for 33 years at -196°C.

description: Experimental and clinical studies of cryopreservation of mouse skin at −20 °C and of human skin at −196 °C. Tail skin of C3H / He mouse was excised and wrapped in the sterile gauze (3 g in weight) and it was kept in the small dish (100 ml in capacity), which was moisten of 100 ml of physiologic saline added 50 mg of Panimysin® and did not include any cryoprotectant. The temperature of the ice box was continuously recorded by the thermistor. During freeze-preservation for five weeks, the highest and the lowest temperature were −10 and −28 °C respectively, and the average was −20 °C. The stored skin was transplanted to the skin defect (1 cm2) created on the back of another C3H / He mouse by the non-suture technique. The macroscopic and microscopic examinations were done from second seek to 8th week after the surgery. Human allogeneic skin graft was harvested from the amputated leg, and cryopreserved in 8 % glycerol solution in TC 199 for 14 days at −196 °C. The graft was transplanted onto the ulcer surface from the left mastectomy. The transplanted mouse skin was taken for 6 months. Human skin grafts stored for 2 weeks at −196 °C under the optimal conditions were taken too, and each methods will be clinically available. The human adipose tissues frozen for 33 years showed confluent MSCs by RFTIVIVSCM, which will be used for long-term cryopreservation of skin, subcutaneous and perivenous fat tissue.
DOI: 10.18462/iir.cals.2016.27
title: The repetitive freeze-thaw-in vivo and in vitro subculture method (RFTIVIVSCM) to indefinitely preserve human bone marrow and adipose tissue derived mesenchymat stromal cells (MSCs) for regenerative medicine.

description: Human vein and perivascular adipose tissue will be a precious source of MSCs for regenerative therapy, however problems in tissue culture remain as for foreign proteins, recombinant stimulants, and the resources for MSCs. Perivenous live “adipose” tissue explants obtained by surgery (82 varices) were cultured in a media including human sera, platelet lysate, limulus lysate et al in a 5 % CO2 at 37 °C and obtained confluent monolayer of MSCs in 35 mm dish. On the other hand, the adipose and vein explants, which were frozen in a 10 % dimethylsulfoxide (Me2SO) in Iscove’s modified Dulbecco’s Medium (IMDM) or in 15 % glycerol in TC 199 in cryovials at −85 °C or in a plastic bag at −196 °C for days~33 years, induced confluent MSCs too after thawing and culture, that is adipocyte-mesenchymal transition (AMT). Those confluent MSCs were gently scraped by trypsin-IMDM or PBS to be proliferated to form passaged MSCs by RFTIVISCM, which was originated from repetitive frozen autologous bone marrow transplantation (FABMT) used to rescue ablated marrow function. RFTIVIVSCM will be an essential technique in regenerative therapy to cryopreserve the MSCs induced from every internal tissue for a long term.
DOI: 10.5281/zenodo.581415
title: Od-1 Open Data Decision Tree Version 0.4

description: This is a prototype/proof of concept upload to Zenodo to test and demonstrate the concept of working in a 'Commons Compliant' way. This involves conducting all stages of research and research communication openly (Open by Design and Open by Default). 

Decision trees record a set of actions that can be taken with scholarly objects to make them as Open, FAIR and Citable as possible. They represent the most practical framework for putting the Principles of the Scholarly Commons into practice.

This tree was uploaded using a Draw.io - Dropbox - Zenodo workflow.
DOI: 10.5281/zenodo.581420
title: Level A Pan Europe Modelled River Discharge, E-Hype 2.5

description: Simulated river discharge at each subbasin from E-HYPEv2.5 in m3/s. Daily data for 1961 to 2001 as time-series. Original data source: See information about the E-HYPE setup. Tools for repurposing: HYPE. Temporal resolution: Daily. Spatial resolution: 215 km2. Unit: m3/s. Data format: Zipped text file. On the first row there is a brief description and the rest of the file contains one row per time step, with the sub basin id as each column header on the second row. The first item on each line is the time step using the format YYYY-MM-DD, so 1961-01-01 for the first of January 1961. The dataset, Subbasin(EHYPE2pt5).zip (shapefile with subbasin polygons) can be linked with the data.
DOI: 10.5281/zenodo.581421
title: Level A Pan Europe Modelled River Discharge, E-Hype 3.0

description: Simulated river discharge at each subbasin from E-HYPEv3.0 in m3/s. Daily data for 1961 to 2001 as time-series. Original data source: See information about the E-HYPE setup. Tools for repurposing: HYPE. Temporal resolution: Daily. Spatial resolution: 215 km2. Unit: m3/s. Data format: Zipped text file. On the first row there is a brief description and the rest of the file contains one row per time step, with the sub basin id as each column header on the second row. The first item on each line is the time step using the format YYYY-MM-DD, so 1961-01-01 for the first of January 1961. The dataset, Subbasin(EHYPEv3pt0).zip (shapefile with subbasin polygons) can be linked with the data.
DOI: 10.5281/zenodo.581422
title: Level A Pan Europe Natural River Discharge, E-Hype 3.0

description: Simulated river discharge at each subbasin from E-HYPEv3.0 in m3/s. Daily data for 1961 to 2001 as time-series. Dam regulation and irrigation are NOT simulated in the natural runs. However, dams will still function as lakes with some amount of attenuation. Original data source: See information about the E-HYPE setup. Tools for repurposing: HYPE. Temporal resolution: Daily. Spatial resolution: 215 km2. Unit: m3/s. Data format: Zipped text file. On the first row there is a brief description and the rest of the file contains one row per time step, with the sub basin id as each column header on the second row. The first item on each line is the time step using the format YYYY-MM-DD, so 1961-01-01 for the first of January 1961. The dataset, Subbasin(EHYPEv3pt0).zip (shapefile with subbasin polygons) can be linked with the data.
DOI: 10.18462/iir.cals.2016.023
title: Novel cryo-racks for different applications in biobanking.

description: While the freezing of cell suspensions is easy to handle since the discovery of cryoprotective agents, the cryopreservation of living tissue is still problematic today. Sophisticated controlled rate freezers for biological samples provide a high cooling performance as well as outstanding freezing rates which should allow reproducible tissue freezing. However, the required temperature homogeneity for multiple sample positions cannot be achieved even with the freezing equipment for biological samples currently available. For this reason, we have developed a range of thermal management units. For instance, our novel Multiwell RACK can cryopreserve up to 96 tissue models by use of the microwell format.
DOI: 10.18462/iir.cals.2016.024
title: Safe reliable drug substance transfers via frozen storage and logistics in single-use containers.

description: As the market for biotherapeutics expands its reach, process transfers continue to increase as new directives promote local final drug product manufacturing for their served market. Biopharmaceutical companies continue to expand their worldwide distribution and drug substance production sites are increasingly de-coupled from their drug product counterpart. Consequently, drug substances are increasingly stored and shipped to remote locations. This is a critical process step yet the challenge to successfully transfer is not well established. One solution is to implement a freezing process in robust single-use containers for safe and reliable storage, and then ship the frozen containers in purpose-designed shippers to safeguard the product and ensure transport integrity. This article introduces the growing need for adoption of freezing operations in biomanufacturing and the typical considerations to implement successfully a global supply chain with product held in a frozen state. Emphasis is given on the required level of thermal and physical qualification of such freeze and thaw systems to adequately protect the product. Finally, the possibility offered by bulk-scale single-use freeze and thaw technologies for “one-way logistics” is described. This concept simplifies the cold chain and increases process efficiency and flexibility.
DOI: 10.18462/iir.cals.2016.25
title: Strategies for the design of bi-layer scaffolds for the regenerative medicine and tissue engineering.

description: In the field of regenerative medicine and tissue engineering 3-dimensional collagen scaffolds play an important role to guide the formation of functional novel tissue structures. Thereby, different cell types often have to be separated for a defined period of time to generate multilayer tissue structures like skin or to control cell migration in the process of tissue regeneration. Such applications require heterogeneous scaffold structures with a bi-layer structure. Such scaffolds can decelerate or prevent cell migration by a barrier of compacted material. Additionally they may provide different pore sizes in both of the separated scaffold areas to perfectly
suit the needs of different cell types. With the patented MBIT technology such materials can be generated in a single freeze-drying process. This novel approach can drastically reduce the production costs for 3-dimensional biomaterials with a multilayer structure because a stepwise construction of those scaffolds or a subsequent combination of two or more separately produced material layers is no longer necessary.
DOI: 10.5281/zenodo.581424
title: Level A Pan Europe Nutrients, Point And Diffuse Sources, E-Hype 2.5

description: Inputs of nitrogen and phosphorus (including fractions of the soluble P from urban point sources (PS1) , industrial point sources (PS3) and rural households (Loc). These values are calculated for each subbasin according to population in the subbasin, assumed connectivity to urban wastewater treatment or not, assumed emissions per person and assumed treatment levels (based on country). These can be downloaded as simulated load to the E-HYPE2.5 subbasins (= subbasin level, subbasin resolution = 215 km2) or as simulated load at the catchment, (subbasin and contribution from upstream area.) Original data source: HYDE population database, EEA treatment level method, EUROSTAT, HELCOM PLC5, E-PRTR. Tools for repurposing: WHIST. Data format: Table (Excel file) with unique subID which could be linked to the shapefile EHYPE_polygons_v2pt5.shp.
DOI: 10.5281/zenodo.581425
title: Po River Daily River Flows 1920-2009

description: Time series of the Po River Daily river flows at Pontelagoscuro from Jan 1st 1920 to Dec 31st 2009. Data are in cubic meters per second. Observations taken on Feb 29th have been removed.
DOI: 10.5281/zenodo.581426
title: Flash Flood Risk Map Hallstatt / Gosau / Bad Goisern: Risk Map

description: Damage Risk Map of FFRM catchment Hallstatt / Gosau / Bad Goisern
based on max. water depth in all timesteps, zoning plan, building density and specific damage function
DOI: 10.5281/zenodo.581651
title: Refactdataset

description: <strong>Overview of Data</strong>

The dataset contains two types of data for each class and method in a system: static source code metrics and number of refactorings (grouped by types) affecting the particular item between consecutive versions

<strong>Attribute Information</strong>

code refactoring, software maintainability, empirical study
DOI: 10.5281/zenodo.581652
title: Refactdatasetvalidated

description: <strong>Overview of Data</strong>

The dataset contains two types of data for each class and method in a system: static source code metrics and number of refactorings (grouped by types) affecting the particular item between consecutive versions

<strong>Attribute Information</strong>

code refactoring, software maintainability, empirical study
DOI: 10.18462/iir.cals.2016.022
title: Scientific conception of freezing steps as a part of pharmaceutical platform technologies.

description: The development of new active agents as recombinant protein is a costly and time-consuming process. After finding the right target there is a lot of R&D work left to identify and optimize the upstream and downstream process before the biologics enter the preclinical and clinical studies. To ensure long term product stability for the case of storage and transport processes often a freezing step is required. Unfortunately, the freezing process itself may influence the product stability in a drastic manner. In that case a preclinical and clinical study is doomed to become a failure. Up to now the optimization of product stability in freezing steps is a costly and time-consuming issue which may require multiple freezing experiments. Our studies have shown that proteins are solely damaged by concentration effects and pH shifts and not directly by thermal effects. If one concerns that only the re-distribution of solute concentrations depending on the freezing, a measurement of the damage potential at ambient temperature is allowed. This scientific know-how enables us to develop a rapid screening method of product quality for the simulation of product loss in freezing steps ― without costly and time-consuming multiple freezing experiments.
DOI: 10.5281/zenodo.581427
title: Hallstatt_Depth_Max_5Cm_60Min_Gen_Wgs84

description: Hallstatt_DEPTH_MAX_5cm_60min_gen_WGS84
DOI: 10.5281/zenodo.581428
title: Cd_Climate_35408_E-Hype

description: Mean annual precipitation, seasonality index of precipitation, mean annual temperature, aridity index calculated for upstream area for all E-HYPE sub-basins outlets. For definitions used for aridity index and seasonality index see reference paper (Kuentz et al., 2016).
Reanalysis temperature and precipitation data for subbasins was taken from the nearest meteorological grid point to each subbasin centroid. Daily time-series over 1979-2010 were used to calculate the different indices. Then, an average value for the whole upstream area of each subbasin outlet was calculated as the mean of all upstream subbasins weighted by their area.
This data can be linked to the shapefile "MULTIHARO_TotalDomain_WGS84_20140428_2" available as a separate download. To do so, link the "SUBID_OUT" filed of the shapefile with the "SUBID" field of this dataset.
description: Precipitation, Temperature and wind have been previously gathered by Donnelly et al., 2016 for E-HYPE model setting (http://hypeweb.smhi.se/) from the WFDEI database (Weedon et al., 2014).
DOI: 10.5281/zenodo.581429
title: Cd_Geology_35408_E-Hype

description: Geological age and type in percentage of upstream area for all E-HYPE sub-basins outlets. 22 different combinations of age and type are used: Cenozoic (Cz), Cenozoic-Mesozoic (CzMz), Cenozoic-Mesozoic intrusive (CzMzi) ), Cenozoic-Mesozoic volcanic (CzMzv), Cenozoic volcanic (Czv), Mesozoic (Mz), Mesozoic-Paleozoic (MzPz), Mesozoic-Paleozoic metamorphic (MzPzm), Mesozoic intrusive (Mzi), Mesozoic metamorphic  (Mzm), Mesozoic volcanic (Mzv), Paleozoic (Pz), Paleozoic intrusive (Pzi), Paleozoic metamorphic (Pzm), Paleozoic-Precambrian (PzpCm), Paleozoic-Precambrian metamorphic (PzpCmm), Paleozoic volcanic (Pzv), intrusive (i), metamorphic (m), Precambrian (pCm), Precambrian intrusive (pCmi), Precambrian volcanic (pCmv).
The "Karst" column indicates the percentage of area which is marked as "carbonate outcrop area" according to the World Map of Carbonate Rock Outcrops V3.0.
This data can be linked to the shapefile "MULTIHARO_TotalDomain_WGS84_20140428_2" available as a separate download. To do so, link the "SUBID_OUT" filed of the shapefile with the "SUBID" field of this dataset.
description: The subcatchments are defined according to the E-HYPE V.3.0.0 model setting (http://hypeweb.smhi.se/, Donnely et al., 2016)
USGS Geological maps of Europe and the Arabian Peninsula (Pawlewicz et al, 1997, Pollastro et al., 1999)
World Map of Carbonate Soil Outcrops V3.0 (http://web.env.auckland.ac.nz/our_research/karst/#karst1).
DOI: 10.5281/zenodo.581430
title: Cd_Landuse_35408_E-Hype

description: Land use types in percentage of upstream area for all E-HYPE sub-basins outlets. 10 different types are used: water, glacier, urban, forest, agriculture, pasture, wetland, open with vegetation, open without vegetation, irrigated.
This data can be linked to the shapefile "MULTIHARO_TotalDomain_WGS84_20140428_2" available as a separate download. To do so, link the "SUBID_OUT" filed of the shapefile with the "SUBID" field of this dataset.
description: Land use percentages have been previously gathered by Donnelly et al., 2016 for E-HYPE model setting (http://hypeweb.smhi.se/) using the following databases:
CORINE; 
GLC2000 (Bartholomé et al., 2005) (for areas not covered by CORINE); 
GGLWD (lake area, distribution, Lehner and Döll, 2004);
EIM (EU scale irrigation, Wriedt et al. 2009); 
GMIA (global scale irrigation, Siebert et al. 2005)
DOI: 10.5281/zenodo.581431
title: Cd_Soiltype_35408_E-Hype

description: Soil types in percentage of upstream area for all E-HYPE sub-basins outlets. 8 different types are used: coarse soil, medium soil, fine soil, peat, no texture, shallow and moraine.
This data can be linked to the shapefile "MULTIHARO_TotalDomain_WGS84_20140428_2" available as a separate download. To do so, link the "SUBID_OUT" filed of the shapefile with the "SUBID" field of this dataset.
description: Soil type percentages have been previously gathered by Donnelly et al., 2016 for E-HYPE model setting (http://hypeweb.smhi.se/) using the following databases:
ESD (Panagos 2006); 
DSMW
DOI: 10.5281/zenodo.581432
title: Cd_Topography_35408_E-Hype

description: Area, mean elevation, standard-deviation of elevation, mean slope, drainage density calculated for upstream area of all E-HYPE sub-basins outlets.
Drainage density is defined as total length of all streams in the catchment divided by catchment area. For length of streams calculation, a stream network layer has been computed based on the HYDRO1K elevation and flow accumulation layers, using a threshold of at least 20 km2 of upstream area for starting a river.

This data can be linked to the shapefile "MULTIHARO_TotalDomain_WGS84_20140428_2" available as a separate download. To do so, link the "SUBID_OUT" filed of the shapefile with the "SUBID" field of this dataset.
description: USGS: elevation, flow accumulation and slope layers from Hydrosheds and Hydro 1K (for latitude &gt;60°) (Lehner et al., 2008)
Most of these descriptors have been previously gathered by Donnelly et al., 2016 for E-HYPE model setting (http://hypeweb.smhi.se/).
DOI: 10.5281/zenodo.581653
title: Istar 2 - Larger Models

description: <strong>Overview of Data</strong>

.vsd files are essentially .xml files which cannot be parsed as we cannot estimate a generic pattern amongst the files to construct a parser. A domain specific language in python is used to draw these models. The template for the DSL can be accessed [here] and a sample model can be accessed [here].

<strong>Attribute Information</strong>

Goal-oriented requirements engineering - Goal modeling - Modeling - Model analysis - Model iteration - Interactive modeling - Satisfaction analysis
DOI: 10.14457/tu.the.2015.65
title: การพัฒนาแบบจำลองเพื่อควบคุมชุดทดลองลูกตุ้มผกผันแบบสองก้านที่มีจุดหมุนเคลื่อนที่ด้วยตัวควบคุมแบบ H-infinity

description: รายงานนี้นำเสนอการศึกษาแบบจำลองทางคณิตศาสตร์สาหรับชุดทดลองลูกตุ้มผกผันแบบจุดหมุนเคลื่อนที่บนตัวรถ และแบบสองก้านที่มีจุดหมุนบนตัวรถซึ่งเป็นแบบเชิงเส้น ซึ่งโดยปกติระบบของชุดทดลองดังกล่าวจะไม่มีเสถียรภาพ ณ ตำแหน่งตั้งตรง จากนั้นทำการออกแบบระบบควบคุมเพื่อสร้างเสถียรภาพ ณ ตำแหน่งตั้งตรงสำหรับชุดทดลองลูกตุ้มผกผันดังกล่าวให้เป็นไปตามข้อกำหนดของการออกแบบกรณีของชุดทดลองลูกตุ้มผกผันแบบจุดหมุนเคลื่อนที่บนตัวรถ ผู้วิจัยทำการเปรียบเทียบผลตอบสนองของระบบที่ได้จากระบบควบคุมต่าง ๆ ดังนี้ ระบบควบคุมแบบพีดี-พีไอดี ระบบควบคุมแบบพีไอดี-พีไอดี ระบบควบคุมแบบกำลังสองเชิงเส้นที่มีเกนป้อนก้าวหน้า และระบบควบคุมแบบกำลังสองเชิงเส้นที่มีตัวกระทำอินทิกรัล ซึ่งหลังจากทำการเปรียบเทียบผลตอบสนองของระบบพบว่าระบบควบคุมแบบกำลังสองเชิงเส้นจะให้ผลตอบสนองของระบบที่ดีกว่าระบบควบคุมพีไอดี โดยเฉพาะอย่างยิ่งระบบควบคุมแบบกำลังสองเชิงเส้นที่มีตัวกระทำอินทิกรัล เป็นผลให้ระบบเข้าสู่สภาวะคงตัวเร็วขึ้นและระบบเกิดการแกว่งน้อยลงกรณีของชุดทดลองลูกตุ้มผกผันแบบสองก้านที่มีจุดหมุนบนตัวรถ ผู้วิจัยทำการศึกษาแบบจำลองทางคณิตศาสตร์ที่เป็นเชิงเส้น โดยเพิ่มการพิจารณาถึงความไม่แน่นอนของค่าพารามิเตอร์ของระบบอีกด้วย การออกแบบระบบควบคุมแบบ H∞ และนำมาประยุกต์ใช้กับชุดทดลองที่สร้างขึ้นในโปรแกรม LabVIEW หลังจากทำการทดสอบพบว่าผลตอบสนองที่ได้จากระบบควบคุม H∞ ที่ได้สร้างขึ้นบนโปรแกรม LabVIEW นั้นสามารถควบคุมชุดทดลองลูกตุ้มผกผันแบบสองก้านต่อกันและมีจุดหมุนเคลื่อนที่บนตัวรถได้ดีสำหรับปัญหาระบบควบคุมแบบคงค่าและปรับค่าตามจุดอ้างอิง
DOI: 10.14457/tu.the.2015.66
title: การเพิ่มขีดความสามารถในกระบวนการรักษามะเร็งตับโดยเติมอนุภาคนาโน (แบบจำลองวัสดุพรุนชนิดไม่สมดุลทางความร้อน)

description: งานวิจัยนี้เป็นการศึกษาการเพิ่มขีดความสามารถในกระบวนการรักษามะเร็งตับโดยเติมอนุภาคนาโน (แบบจำลองเป็นวัสดุพรุนชนิดไม่สมดุลทางความร้อน) โดยใช้คอมพิวเตอร์ช่วยจำลอง ซึ่งใช้ความร้อนจากคลื่นไมโครเวฟเพื่อให้เนื้อเยื่อดูดซับคลื่นผ่านท่อนำคลื่น แบบจำลองทางคณิตศาสตร์ที่ใช้ในการวิเคราะห์ อยู่บนพื้นฐานของสมการแมกซ์เวลล์ สมการไบโอฮีท ในการจำลองเชิงตัวเลขใช้ระเบียบวิธีไฟไนท์เอลิเมนต์แบบสมมาตรรอบแกนในการคำนวณแบบจำลองทางคณิตศาสตร์ เพื่ออธิบายการกระจายตัวเชิงอุณหภูมิภายในเนื้อเยื่อตับในการศึกษานี้ได้ทำการศึกษาอย่างเป็นระบบถึงอิทธิพลของค่ากำลังจากคลื่นไมโครเวฟที่ส่งผลต่อพลังงานความร้อนจากคลื่นไมโครเวฟเชิงปริมาตร ค่าอัตราการกระจายตัวของพลังงานดูดซับที่เกิดจากคลื่นไมโครเวฟ การกระจายตัวเชิงอุณหภูมิ และผลของอนุภาคนาโน และนำผลการทดลองที่ได้ไปเปรียบเทียบกับการทดลองจริง ผลจากการจำลองในการศึกษานี้ สามารถนำไปใช้เป็นแนวทางในการรักษาในเชิงปฏิบัติ และเป็นการส่งเสริมการพัฒนาเทคโนโลยีการสังเคราะห์ขั้นสูงในมนุษย์ โดยใช้ศาสตร์ในแขนงชีวกลศาสตร์ต่อไป