cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/jwp8bbkyz5
title: Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development

description: The pathogenesis of rheumatoid arthritis (RA) is complex and existing drugs have many shortcomings, including low response rates, adverse reactions, and drug resistance. A specific subtype of CD4+ T cells, T help 9 (Th9) cells, known for secreting IL-9, has been implicated in various autoimmune diseases. Th9-derived IL-9 is highly expressed in patients with RA. However, its precise relationship with RA pathogenesis is unknown. Our previous study demonstrated that PU.1, an essential transcription factor, plays a promoting role in RA pathogenesis. Here, we show for the first time that PU.1 can cause T cell abnormality in RA by promoting Th9 differentiation and IL-9 production. Our results demonstrate that PU.1 and IL-9 form a positive feedback loop in RA: 1) PU.1 directly binds to the IL-9 promoter, activating its transcription, and 2) Th9-derived IL-9 induces PU.1 via the IL-9R-JAK1/STAT3 pathway. In conclusion, we demonstrate that the PU.1-IL-9 axis forms a positive loop in Th9 dysregulation of RA. Targeting this signalling axis presents a potential target approach for treating RA.
DOI: 10.17632/mtwr78ktst
title: Combined irradiation by gamma-rays and carbon-12 (12C) nuclei caused hyperlocomotion and change in striatal metabolism of rats

description: Here, we investigated grip strength, motor activity and habituation after acute irradiation (combined 0.4 Gy gamma-rays and 0.14 Gy 12C nuclei) of 5-month-old Wistar rats. At the same time, we performed neurochemical and molecular analysis of the nucleus accumbens and the dorsal striatum.
The Dataset.xlsx file contains raw data from: 1) behavioral testing of irradiated Wistar rats, 2) HPLC analysis of monoamines and their metabolites, 3) HPLC-MS analysis of choline, glutamate, glutamine, pyroglutamate, N-acetylaspartate, 4) RT-PCR - gene expression analysis of synaptic trafficking participant genes, and 5) Western-blotting analysis of synuclein and syntaxin 1A
The Immunoblotting.zip archive contains the original Western-blotting membrane photographs
DOI: 10.17632/tfr4nxt8g3
title: Brain-Based MotionEncoder

description: This data is from the biological section of the paper titled ‘Identification of movie encoding neurons enables movie recognition AI’ published in PNAS.
DOI: 10.17632/wjxr6hw4df
title: Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma

description: Phospho Antibody Array
DOI: 10.17632/x548wt5kzh
title: Smugglers

description: Simulation program (Maple 18) and results (pdf)
DOI: 10.17632/4gxt699bvy
title: LDHU3_11.0320

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/6wvj6k57k5
title: Global System Integration Company, Qlik Implementation, and Software System Integrators

description: Finesse is a global software system integrator based in Dubai, UAE. We are Salesforce Partners assisting over 400+ enterprise clients globally, driving their digital transformation.We do implementation of chatbots to enhance customer experience.
DOI: 10.17632/ckzvncwjxy
title: DS Gadzhiev

description: Описание переменных, используемых в регрессионных моделях:
• ROA - рентабельность активов (return on assets), рассчитываемая как отношение чистой прибыли компании к среднему значению общей суммы активов за текущий и предыдущий период;
• ATO коэффициент оборачиваемости активов, рассчитываемый как отношение выручки компании к среднему значению общей суммы активов за текущий и предыдущий период;
• SGR – устойчивый рост компании;
• HCE - эффективность человеческого капитала;
• SCE - эффективность структурного капитала
• CEE - эффективность задействованного капитала
• RDE - эффективность инновационного капитала
• RCE - эффективность отношенческого капитала
• Lev - финансовый рычаг (leverage), рассчитываемый как отношение общей суммы обязательств к общей сумме активов
• Size - размер компании, рассчитываемый как натуральный логарифм общей суммы активов компании
DOI: 10.17632/y9sntnf5bm
title: Brocchi. Conchiologia fossile subapennina avec des observations géologiques sur les Apennins et sur le suolo adiacente. vol. 1. Milano: 1824. 529-550.

description: Indicates the taxonomy of some species in our study area.
DOI: 10.17632/ynjys76nnk
title: LINF_220007500

description: Translocon-associated protein (TRAP)
Leishmania infantum (strain JPCM5)
DOI: 10.17632/2tv8sx62j2
title: Data-C. Roseus

description: The QTL and consensus map file.
DOI: 10.17632/3cjvtx6cpt
title: Dataset: Assessing Stakeholder Involvement for Sustainable Nature-Based Tourism: A Conceptual Governance Framework applied in the Ecuadorian Amazon

description: It contains map metadata, codes, figures and tables of results.
DOI: 10.17632/3t3xxwjb37
title: LINF_180016100

description: Vps16-like protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/3zc5xjwb7d
title: MMP12

description: MMP12 expression in nomal and cervical cancer
DOI: 10.17632/c8h2bggcj3
title: Hesperidin provides synergistic effect in conferring neuroprotection to rats maintained on a regimen of alternate day fasting

description: Background. Alternate day fasting (ADF) is a beneficial dietary intervention that reduces age- associated complications. Hesperidin is a potential antioxidant especially known for free radical scavenging ability. Oxidative damages are a major cause of neurological changes in brain that accelerates deteriorative effects leading to aging. In the current study, we aimed to investigate the role of hesperidin supplementation on neuroprotection conferred in terms of redox balance in rats that were maintained on an ADF regimen. Methods and Results. Middle aged male Wistar rats (Rattus Norvegicus) (12-15 months) were divided into four groups: Group I. Control; Group II. ADF; Group III. Hesperidin; Group IV. ADF+ Hes (maintained under ADF regimen and given hesperidin regularly). The number of rats maintained in each group is 6. We measured crucial biomarkers of antioxidant defense like FRAP, GSH, SOD, catalase, and oxidative stress MDA, PCO, AOPP, NO, inflammatory cytokine (IL-6 and TNF-α) and autophagy expression. The results provide evidence of a synergistic benefit obtained in crucial parameters of antioxidant defense including FRAP, GSH, SOD, catalase and autophagy expression (Beclin gene) alongwith decrease in MDA, PCO, AOPP, NO and inflammation markers. The activity of the mitochondrial electron transport chain complexes showed increased efficiency and the histopathological changes show well protected neurons and lesser neurodegeneration. Conclusion. The results support administration of hesperidin during ADF regimen to obtain additional benefits and protection from aging induced oxidative stress and to reduce the incidence of common metabolic morbidities like impaired glucose levels and attenuate redox imbalance thus conferring neuroprotective effects.
DOI: 10.17632/dct2dt4fdj
title: Data for: Factors associated with non adherence to gluten free diet in adult Celiac patients in Israel

description: statistcs analysis
DOI: 10.17632/fjtsjrrvst
title: Conceptual Challenges to the Recognition and Enforcement of the Right to Clean, Safe and Healthy Environment

description: The right to clean or healthy environment, or what may be called environmental right, is one of the most controversial emerging rights since the agitation for the recognition of the link between human rights and the environment started gaining momentum at international law forums. This is happening partly because, at the global level, no treaty attempts to delimit the scope of this right explicitly; an endeavour which would have served as a form of guide to national jurisdictions. Given that the UN General Assembly recently officially resolved that a clean, healthy and sustainable environment is a universal human right, and considering the implication this may have on national jurisdictions, it has become more imperative to redefine this right for the ease of enforcement. This paper seeks to examine the conceptual and the theoretical conundrum as well as the criticisms of the right to clean, safe and healthy environment that have largely played a prominent role against the enforcement of the rights in general. The paper also examines constitutional challenges associated with the recognition of the rights in Nigeria and the judicial effort in the case of Gbemre v SPDC in attempting to expound the constitutional right to life to include the right to the environment. The paper finds that the right to the environment has been described and qualified diversely from one jurisdiction to another rendering the same susceptible to the challenges of interpretation. The paper, however, suggests that given the importance of the right, same should be interpreted, no matter how it is qualified, to mean a right to an environment fit for human living, the courts being sufficiently able to draw the line between what environment is fit and what is not for human habitation.
DOI: 10.17632/fydgskp484
title: Irradiance Meter

description: List of files for building a low-cost global irradiance meter using Arduino.
DOI: 10.17632/jrv5fxtwt6
title: Raw data-Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data

description: raw data of the research work
DOI: 10.17632/prrk4sw8n4
title: Alternate day fasting attenuates altered ion homeostasis, intracellular ROS in rats during aging

description: Alternate day fasting (ADF) is an intervention strategy that has shown potential in delaying aging-induced complications. However, the effect of ADF on cellular ion transport is still a grey area although the intracellular ROS (Reactive Oxygen Species) may contribute in the ionic homeostasis levels. In this study the role of ADF in the modulation of the plasma membrane associated pumps Na+-K+ ATPase (NKA) and the Na+- H+ exchanger (NHE) has been studied during aging in rats. Materials and Methods. The number of rats maintained in each group is 6. Experimental rats were maintained on a regimen of ADF. The experiment has been performed on young and old male Wistar rats. The NKA pump and NHE activity was measured in erythrocyte membrane during aging in rats. The osmotic fragility of erythrocytes was also measured which gives us the impact of ADF on the membrane transporters levels during aging. An assay of the intracellular ROS level was also performed in the rat erythrocytes. Results. It has been observed that ADF improves the cellular ion homeostasis during aging, an effect more evident in old aged rats.
DOI: 10.17632/rnjt3rkpk5
title: Quasi-static Biot

description: These data contain the 2D layered model of poroelatic media used to estimate the effective velocities and attenuation of seismic waves if they propagate in such media. Additionally, the results of quasistatic loading simulations for different frequencies are provided. Finally, it contains the MatLab script that reads the model and the simulation results and constructs an estimation of the frequency-dependent velocity and attenuation. A detailed description of the data structure is provided in the readme.txt file.
DOI: 10.17632/rznx883svp
title: Data for: Petrogenesis of deformed tourmaline leucogranite in the Gurla Mandhata metamorphic core complex, Southwestern Tibet

description: All data in this paper
DOI: 10.17632/zwwjs26hmz
title: LINF_060006500

description: 20S proteasome beta 6 subunit; Leishmania infantum
DOI: 10.17632/5y5gdb5853
title: Persuasive Messages to Prevent Anti-Vaccination Movement: Does Construal Level Matter?

description: This dataset was used to examine the impacts of construal level, message framing and temporal distance on the individual’s opinion towards anti-vaccination movement.
DOI: 10.17632/97cznzzcvg
title: Supplementary file 1 (Thesis)

description: List of Transcripts cell type-specific
DOI: 10.17632/dmkstkx3pz
title: The data for influence of light spectrum on body color of turbot juveniles

description: The data for Comparative transcriptome analysis reveals growth and molecular pathway of body color regulation in turbot (Scophthalmus maximus) exposed to different light spectrum
DOI: 10.17632/fr7xm79k4s
title: LINF_310036600

description: ADP-ribosylation factor | Arf1
Leishmania infantum (strain JPCM5)
DOI: 10.17632/k79n9m3nm8
title: LINF_300005100

description: Alpha/beta hydrolase family protein
Leishmania infantum (strain JPCM5)
DOI: 10.17632/p9pp5rggh3
title: Supplement Table 1-5

description: Supplement table 1-5
DOI: 10.17632/ptxg6tywrz
title: LINF_230018000

description: protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/x7tvmxnb5t
title: Risk Factors for Mortality in Melioidosis: A single centre 10-year retrospective cohort study

description: Dataset obtained from patient medical records of Amrita Institute of Medical Sciences for the retrospective study, " Risk Factors for Mortality in Melioidosis: A single center 10-year retrospective cohort study"
DOI: 10.17632/x8jhmcd72t
title: Raw data-Diffusion tensor imaging for the study of early renal dysfunction in patients affected by bardet-biedl syndrome

description: raw data of the research work
DOI: 10.17632/4t73j3nnt5
title: Oroxylum indicum metabolomics

description: LCMS/MS and HRMS data sheet
DOI: 10.17632/bg8vym6s8c
title: From jobs to careers_drivers and barriers to career development in emerging labor markets

description: Primary raw data
DOI: 10.17632/p82b7tmjg9
title: Literature selection for "thyroid hormone supplement and organ donation"

description: This file includes 27 original articles selected against strict criteria for a systematic review and meta-analysis. The review discusses the effects of thyroid hormone supplement on brain-dead donors.
DOI: 10.17632/p98nr43rz3
title: Identification of Isoform p-53 Protein in CLL by Elisa Method 

description: The monoclonal p-53 antibody, PAb 240, used in the ELISA method recognizes both mutant and wild-type p-53 under denaturing conditions. Species reactivity is for human or rhesus monkey in conformity with the prospect. The monoclonal antibody PAb 240 recognizes an epitope that is structurally hidden in the wild-type conformation of p-53 and becomes exposed by denaturing the p-53 protein or the mutant conformations of p-53, where point mutations in the P-53 gene alter the terminal structure of the p-53 protein. This ELISA kit is recommended for use in serum, plasma or tissue homogenates. Using other types of sample is not supported. The sample collection protocols below were adapted from the references.
Results
Of the 20 patients studied, 14 men have aged 55-85 years and 6 women aged 39-85 years. Patients were treated at the time of these investigations with cytostatic and immunotherapy specific for CLL. For the men the results of protein concentration p-53 detection were following values, 20, 15, 18, 40, 10, 12, 14, 60, 30, 10, 13, 13, 5, 10, 15, 12,  (µg / dl) and women's results of protein concentration p-53 were 140, 30, 13, 10, (µg / dl), 
The pathological values in the 3 cases of highly elevated p-53, reflecting the concentration of p-53 protein mutant, were calculated in 2 men in the amount of 60 µg / dl, respectively in 50 µg / dl, and in the female case, it was calculated in the amount of 140 µg / dl, the frequency of chronic lymphocytic leukemia being higher in men than in women, in ratio 2/1, in accordance with the data from the specialized literature. The overall frequency of positivity of the p53 protein, in the increased number of CLL cases studied, was 15% (3 out of 20 cases). The expression of the high-concentration p53 proteins in stage 2/3 of the disease was associated with a significantly weaker response to chemotherapy (p = 0.034).
   Statistical interpretations: the concentration of p-53 protein, in the 17 cases with p-53 protein expression, after excluding the 3 out-line cases present in the study, was calculated at the average value of 16.76µg / dL. In the CLL stage III/IV (n = 3 patients (Table 1), 
    In the presented work with CLL, in the stage I/II, (n=17 patients) was registered in the average p-53 protein concentration in CLL, 16.76, (µg/dl), with mean values of hemogram: hematological parameters in peripheral blood, Leukocytes numberer = 35-50 x 10 3 / dL, Hb = 11.8g /dL; Platelet = 140 x 103/dL, Lymphocytes in peripheral blood = 65-80%. 
In some international studies, the immunological characteristics of patients with CLL having p-53 protein positive, were measured by immunohistochemistry, (IHC). In the second part of the study CLL on the stage I/II, (n=47 patients), the P-53 protein isoform concentration in reactive Lymphocyte B, the average p-53 protein concentration in CLL was on average 47 U/m with 16.7% samples studied, (7 out of 42 cases).
DOI: 10.17632/swy5rzbmrd
title: Coronaviruses proximities through nucleotide sequences

description: 1. Viruses_initial_ds.csv: initial data obtained from SARS CORONAVIRUS ACCESSION dataset at https://www.kaggle.com/datasets/jamzing/sars-coronavirus-accession.
2. pairwise_compare_ds.csv: pairwise comparison of viruses for total nucleotide matches by position, largest match block length, and number of match blocks (or shares).
3. total_matches.csv: square matrix virus to virus total matches length.
4. largest_block.csv: square matrix virus to virus largest match block length.
5. shares.csv: square matrix virus to virus number of shared match blocks.
6. ttl_max_shares_3D.pkl: items 3-5  data reduced by PCA to 3D.
DOI: 10.17632/y7zs6h5kbg
title: Qualitative data from Haramaya, Ethiopia 2023

description: FGDs and IDIs from Haramaya, Ethiopia re Khat
DOI: 10.17632/yx9bv9z9fb
title: Supplementary data

description: Date for major and trace element, U-Pb dating and Hf isotope of zircon in Table S1, Table S2 and Table S3, respectively.
Date for figure 10b, figure 11 and figure 12b in Table S4, Table S5 and Table S6,respectively.
Method of phase equilibrium modelling in Supplementary 1.
DOI: 10.17632/b2swfgm7pt
title: Complete mitochondrial genome of the ghost crab Ocypode stimpsoni Ortmann, 1897

description: We analyzed the complete mitochondrial genome sequence of Ocypode stimpsoni. Whole-genome sequencing was performed using the MGISEQ-2000 platform. The length of the complete mitochondrial genome was 15,557 bp, and data were submitted to NCBI (MN917464).
DOI: 10.17632/dcgx6cby5n
title: LINF_280034300

description: protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/fhrd5cbcx9
title: Atlas clínico para instrução em leishmaniose tegumentar americana

description: Atlas clínico para instrução em leishmaniose tegumentar americana
DOI: 10.17632/fwz5t4482z
title: LINF_310016600

description: protein of unknown function - conserved
Leishmania infantum (strain JPCM5)
DOI: 10.17632/k3t56znzng
title: Dataset_EDU2017-82862-R_Moral_Competence

description: Effects of two strategies to teach moral competence in regular courses of teacher education were hypothesized. Results showed a significant increase in moral competence after the application of a variant of the Konstanz Method of Dilemma Discussion, but not when this method was combined with empathy training. Full information about the theoretical framework, hypotheses, method, results and discussion is currently under review.
DOI: 10.17632/m9tbwbhzsg
title: Transformation from oxidized to reduced alkaline magmas

description: Data about alkaline rocks
DOI: 10.17632/n9d3sjry94
title: Interaction of Shibantan Biota and environment in the terminal Ediacaran ocean: evidence from I/(Ca+Mg) and sulfur isotopes

description: Geochemical results of Shibantan member, Dengying Formation at Wuhe, South China
The data is related to a peer-reviewed paper that will be published in Precambrian Research with the same title. See details including the method, hypothesis, and discussion in that paper.
DOI: 10.17632/rv5wbx6fz8
title: ARE COMORBIDITIES ASSOCIATED WITH OVERALL SURVIVAL IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA?

description: We show the methods applicated in our study
DOI: 10.17632/vxvnmyxj3h
title: raw image data for "Resilient anatomy and local microplasticity of naïve and stress hematopoiesis "_18

description: raw image data for "Resilient anatomy and local microplasticity of naïve and stress hematopoiesis "_18
DOI: 10.17632/9x2hvryd67
title: Transcriptome analysis reveals the potential mechanisms of growth arrest and survival of large to giant congenital melanocytic nevus: senescence-like cell cycle arrest and immune evasion

description: Mendeley supplemental figure 1. Differently expressed genes in large to giant melanocytic nevus. The red dots represent the up-regulated genes, and the green dots represent the down-regulated genes. The grey dots are genes without significant difference in expression.
DOI: 10.17632/bvfjjvsxfm
title: Synthesis dataset key socio-economic indicators of northern Norway relevant for the transportation system

description: This is a supplement to the working paper "Transportation systems interconnectedness with socio-economic development in Arctic peripheries: Towards a planning framework".
This synthesis dataset summarizes key socio-economic indicators relevant to the transportation system in Arctic peripheries with Northern Norway as a case study. Counties of Finnmark, Nordland and Troms.
DOI: 10.17632/ng8kd9wszx
title: Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling

description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for causing the COVID-19 pandemic, can be detected in untreated wastewater. Wastewater surveillance of SARS-CoV-2 complements clinical data by offering earlier community-level detection, removing underlying factors such as access to healthcare, sampling asymptomatic patients, and reaching a greater population. Here, we compare 24-hour composite samples from the influents of two different wastewater treatment plants (WWTPs) in South Carolina, USA: Columbia and Rock Hill. The sampling intervals span the months of July 2020 and January 2021, which cover the first and second waves of elevated SARS-CoV-2 transmission and COVID-19 clinical cases in these regions.
DOI: 10.17632/p7rc5pp6gb
title: Martin Lake isotope geochemistry and sedimentology

description: This dataset contains oxygen and carbon isotope ratios preserved in sediment cores recovered from Martin Lake, Indiana, USA. Also included is a record of variability in the clastic/lithic fraction of the same sediments. These data span approximately the past 7,000 years.
DOI: 10.17632/v422mw9jrb
title: LINF_350029800

description: ubiquitin-protein ligase | HECT10
Leishmania infantum (strain JPCM5)
DOI: 10.17632/vdcvjtsc4m
title: Los Humeros Geothermal Field - Shear wave splitting data

description: A study of anisotropic characteristics based on shear wave splitting parameters (fast shear wave polarization and delay time) was carried out from microearthquakes recorded from a network of thirteen seismic stations temporarily installed in Los Humeros Volcanic Complex, Puebla, Mexico from 2011 to 2016.
DOI: 10.17632/4595xbskf7
title: LINF_350022400

description: dynein-associated protein
Leishmania infantum (strain JPCM5)
DOI: 10.17632/52fc949g5t
title: Data for "Right-wing Authoritarianism Between Different Religions and its Negative Effect on Attitudes and Behaviors Toward COVID-19 Policies in Brazil"

description: The data includes 1,461 cases obtained through an online survey created specifically for this study, administered via the Survey Monkey application in May 2020, and respondents were recruited through the Facebook Advertising System (Facebook Ads).