cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7974140
title: Fluorescent Sensors Based on Cu-Doped Carbon Quantum Dots for the Detection of Rutin

description: In this paper, Cu-doped carbon quantum dots (Cu-CQDs) were prepared by carrying out thermolysis of Na2[Cu(EDTA)] and hydroxylamine hydrochloride at 300 ºC for 2 h. The as-prepared Cu-CQDs were characterized by UV-Vis, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The Cu-CQDs exhibited good fluorescence property, high stability, excitation-dependent emission behavior and a quantum yield of 9.8%. More significantly, the synthesized Cu-CQDs were developed for sensing rutin (RT) based on the fluorescence quenching of the prepared Cu-CQDs. A good linear relationship between the fluorescence quenching of Cu-CQDs and different concentrations of RT was obtained in the range of 0.1-15 µg mL-1 with a correlation coefficient of 0.9959. The detection limit was as low as 0.05 µg mL-1 (signal-to-noise ratio, S/N = 3). The possible mechanism of fluorescence quenching was explored, which was proved to be inner filter effect. Importantly, the proposed method was successfully applied in the detection of RT tablet samples and with satisfactory results, showing the practical applications.
DOI: 10.6084/m9.figshare.24076626.v1
title: Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after consecutive respiratory virus infections in ferrets

description: All quantitative source data.
DOI: 10.6084/m9.figshare.7974164
title: Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

description: Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human skin/blood samples that would elucidate the molecular mechanisms by which ustekinumab calms psoriasis skin lesions. To investigate the efficacy and molecular pathway (RORC, t-BOX and GATA) of ustekinumab in treating patients with psoriasis skin lesions. A total of 30 patients with psoriasis were randomized into placebo group and treatment group. PASI of each patient was calculated at 0, 12 and 24 weeks post-treatment. The mRNA levels of RORC, t-BOX and GATA in peripheral blood mononuclear cells separated from patients’ whole blood were analyzed using qPCR. Decreased mRNA of RORC, t-BOX and GATA were observed after continuous injections, indicating that ustekinumab exerts its effect by interacting with these molecules; while no significant difference in foxp3 mRNA levels were found between placebo group and treatment group.
DOI: 10.17632/88rkr6rm5p.1
title: Comparison of eight sequential online motor assessment of patients with Parkinson disease by multiple raters in different locations

description: Detection of movements in the extremities of people with Parkinson disease was developed to enhance clinical assessments. This data represents the administration of online motor assessments to detect the movements in the extremities of people with Parkinson's disease by examiners certified in the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (Goetz, et al., 2008). 


Ten trained raters who were certified in the administration of the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (Goetz, et al., 2008) conducted 8 online motor assessments for one patient with Parkinson disease. Each rater utilized a separate computer at different location in three continents. At the beginning of each session the patient was asked for his permission to record the session. Second, the investigator asked the patient about the current medications and weight. Third, the investigator announced each motor assessment by saying the number and the name of each task before conducting the task for all of the raters. Fourth, the investigator gave the patient the specific instructions for each task, demonstrated each task, and asked the participant to begin the task. The investigator didn't continue to demonstrate the task after the participant began the task. For the repetitive items the investigator asked the participant to perform the activities as fully and as fast as possible. After performing each task the raters were given one minute to write their scores. This process was repeated for all of the tasks. At the conclusion of the session the participant was excused after setting the next session date, and then all of the raters shared their scores with the investigator by email. Finally the investigator conducted a consensus conference to attain agreement on each score for each task. 



One expert certified in the MDS-UPDRS (Goetz, et al., 2008) edited the original videotapes to extract only the administration of each task.The videotape segments correspond to the tasks of the protocol (3.17RTU: 3.17 Rest tremor amplitude upper limbs, 3.17RTUC: 3.17 Rest tremor amplitude upper limbs counting, 3.15PT: 3.15 Postural tremor of the hands, 3.4FT: 3.4 Finger tapping, 3.5HM: 3.5 Hand movements, 3.6PS: 3.6 Pronation-supination movements of the hands, 3.9ACU: 3.9 Arising from chair upper limbs).
DOI: 10.6084/m9.figshare.7974140.v1
title: Fluorescent Sensors Based on Cu-Doped Carbon Quantum Dots for the Detection of Rutin

description: In this paper, Cu-doped carbon quantum dots (Cu-CQDs) were prepared by carrying out thermolysis of Na2[Cu(EDTA)] and hydroxylamine hydrochloride at 300 ºC for 2 h. The as-prepared Cu-CQDs were characterized by UV-Vis, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The Cu-CQDs exhibited good fluorescence property, high stability, excitation-dependent emission behavior and a quantum yield of 9.8%. More significantly, the synthesized Cu-CQDs were developed for sensing rutin (RT) based on the fluorescence quenching of the prepared Cu-CQDs. A good linear relationship between the fluorescence quenching of Cu-CQDs and different concentrations of RT was obtained in the range of 0.1-15 µg mL-1 with a correlation coefficient of 0.9959. The detection limit was as low as 0.05 µg mL-1 (signal-to-noise ratio, S/N = 3). The possible mechanism of fluorescence quenching was explored, which was proved to be inner filter effect. Importantly, the proposed method was successfully applied in the detection of RT tablet samples and with satisfactory results, showing the practical applications.
DOI: 10.6084/m9.figshare.7974212
title: Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inﬂammation in rats by regulating the TLR4 signaling pathway

description: The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inﬂammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.) signiﬁcantly attenuated inflammation in livers of CCl4-treated rats. STM remarkably reduced the production of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1a (MIP-1α), and monocyte chemotactic protein-1 (MCP-1) in liver tissue of CCl4-treated rats. In addition, STM treatment downregulated connective tissue growth factor (CTGF) and ser307pIRS-1 expression, which was induced by CCl4 exposure. In the process of exploring the anti-inflammatory mechanisms of STM action, we demonstrated that STM signiﬁcantly inhibited Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65 expression in the liver. In conclusion, these results suggested that the inhibition of CCl4-induced inﬂammation by STM was, at least in part, due to its regulation of the TLR4 /NF-κB signaling pathway.
DOI: 10.6084/m9.figshare.24032430
title: Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages

description: Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages
DOI: 10.17632/t4w849crj8.1
title: European beech growth and productivity response to climatic transfer

description: Data for the article "Growth and productivity of European beech populations show plastic response to climatic transfer at the north-eastern border of the species range"
DOI: 10.6084/m9.figshare.24847581
title: Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

description: The source data for "Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function".
DOI: 10.6084/m9.figshare.6401441
title: Additional file 1: of Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice

description: TableÂ 1. Antibodies used for western blot and immunofluorescence in this study. (XLSX 8Â kb)
DOI: 10.6084/m9.figshare.24607668.v1
title: Neural network enabled nanoplasmonic hydrogen sensors with 100 ppm limit of detection in humid air

description: These data constitute the full set of results used to generate the corresponding study.
DOI: 10.17632/nz5hm8y4gd.1
title: Real Time Tele-Reflectance Confocal Microscopy in Clinical Dermatologic Practice: A Prospective Observational Study

description: Supplemental material for JAAD research letter
DOI: 10.17632/nz5hm8y4gd.2
title: Real Time Tele-Reflectance Confocal Microscopy in Clinical Dermatologic Practice: A Prospective Observational Study

description: Supplemental material for JAAD research letter
DOI: 10.17632/nz5hm8y4gd.3
title: Real Time Tele-Reflectance Confocal Microscopy in Clinical Dermatologic Practice: A Prospective Observational Study

description: Supplemental material for JAAD research letter
DOI: 10.6084/m9.figshare.6401459
title: Additional file 2: of Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice

description: TableÂ 2. Primers used for PCR in this study. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6401441.v1
title: Additional file 1: of Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice

description: TableÂ 1. Antibodies used for western blot and immunofluorescence in this study. (XLSX 8Â kb)
DOI: 10.17632/5w4byxg2xz.1
title: Supplemental material - Intensive versus conservative blood pressure target after thrombectomy: A systematic review and meta-analysis of randomized controlled trials

description: Supplemental material.
DOI: 10.6084/m9.figshare.6401459.v1
title: Additional file 2: of Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice

description: TableÂ 2. Primers used for PCR in this study. (XLSX 9Â kb)
DOI: 10.17632/cr3gjdh8mz.1
title: Demonstration of silver nitrate technique for the treatment of hidradenitis suppurativa

description: Video demonstrating the silver nitrate technique for the treatment of hidradenitis suppurativa.
DOI: 10.17632/m6tpz586dc.1
title: The data template and script code for the Procrustes analysis

description: Procrustes analysis in R
DOI: 10.17632/ytyyjcz3w3.3
title: Raw Data and RCode: Heatwave-like events affect drone production and brood-care behaviour in bumblebees

description: Raw data, research codes, and table (statistical models) for manuscript "Heatwave-like events affect drone production and brood-care behaviour in bumblebees".

Objective of study: Investigate the impact of simulated heatwaves on the performance of queenless microcolonies of Bombus terrestris audax under laboratory conditions.

Mortality (File: Mortality_status.csv):
The mortality of workers was measured over the five-week period on a daily basis (number of dead workers per microcolony) (See Manuscript Codes - Colony Performance.R and/or Table_Models.docx for model).

Colony Growth (File: Colony_Growth.csv):
The number of drones per microcolony and treatment was measured at the end of the five-week period (See Manuscript Codes - Colony Performance.R for model). The exact number of drones produced per microcolony is shown in File: Colony_Growth.csv.
The number of discarded larvae per microcolony was measured on a daily basis throughout the five-week period (See Manuscript Codes - Colony Performance.R for model). The number of eggs, larvae, and pupae per microcolony is shown in File: Colony_Growth.csv.

Food Consumption (File: Food_consumption.csv):
The volume of syrup feeders was taken every three days over the five-week period and the total average was obtained (nine measurements per microcolony); ml) (See Manuscript Codes - Colony Performance.R for model).

Weight change (File: Weight_data.csv):
Weight change of workers was obtained by collecting each individual bee with a marking cage (with the weight of the cage subtracted) and subsequently weighing them individually once a week over a five-week period using an analytical balance (body mass; mg) (See Manuscript Codes - Colony Performance.R for model).

Body Size and Body Mass (File: Drone_mass_size.csv):
Body size (intertegular distance; mm) was obtained by measuring the distance between the bases of the wings on the bee thorax with a digital calliper after the five-week period, and the dry body mass of drones (dried at 60 ºC for five consecutive days after the five-week period and weighed to the nearest mg (VWR® LA Classic Analytical Balance)) (See Manuscript Codes - Colony Performance.R for models).

Behaviour (File: Behaviour_Data.csv):
The total number of workers engaged in wing fanning (fanning with spread wings for at least 5 s) and the total number of workers incubating the brood (positioned on top of brood with curled abdomen for at least 5 s) were recorded throughout the heatwave simulation period. The behaviour (h-i) of workers in each microcolony was observed continuously for 7 minutes divided into 5 intervals (1 min 40 s each) on a daily basis during the heatwave simulation for a total of five days (total of 35 min per microcolony) (See Manuscript Codes - Colony Performance.R for models). 


Author Names and Affiliations: Yanet Sepúlveda, Elizabeth Nicholls, Wiebke Schuett, Dave Goulson. School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK.
DOI: 10.17632/ytyyjcz3w3.1
title: RCode: Heatwave-like events affect drone production and brood-care behaviour in bumblebees

description: Research codes for manuscript "Heatwave-like events affect drone production and brood-care behaviour in bumblebees". Objective of study: Investigate the impact of simulated heatwaves on the performance of queenless microcolonies of Bombus terrestris audax under laboratory conditions. Author Names and Affiliations: Yanet Sepúlveda, Elizabeth Nicholls, Wiebke Schuett, Dave Goulson. School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
DOI: 10.17632/ytyyjcz3w3.2
title: Raw Data and RCode: Heatwave-like events affect drone production and brood-care behaviour in bumblebees

description: Raw data and research codes for manuscript "Heatwave-like events affect drone production and brood-care behaviour in bumblebees". Objective of study: Investigate the impact of simulated heatwaves on the performance of queenless microcolonies of Bombus terrestris audax under laboratory conditions. Author Names and Affiliations: Yanet Sepúlveda, Elizabeth Nicholls, Wiebke Schuett, Dave Goulson. School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
DOI: 10.6084/m9.figshare.24230525
title: A new tanystropheid (Diapsida: Archosauromorpha) from the Middle Triassic of SW China and the biogeographical origin of Tanystropheidae

description: Tanystropheidae is a clade of early archosauromorphs with high morphological disparity and a wide geographical distribution. The origin and early radiation of Tanystropheidae are still incompletely understood. Here we report <i>Luxisaurus terrestris</i> gen. et sp. nov., a new archosauromorph collected from the marine Upper Member of Guanling Formation (Pelsonian substage, Anisian, Middle Triassic) in Luxi County, Yunnan Province, China, and phylogenetically recovered as a tanystropheid. The morphology of <i>Luxisaurus</i> is consistent with a terrestrial lifestyle. This is the first occurrence of a tanystropheid found from the Anisian Guanling Formation in SW China and also the earliest tanystropheid from the eastern Tethys. Phylogenetic analysis shows that Dinocephalosauridae forms the sister group of Tanystropheidae, <i>Fuyuansaurus</i> occupies the most basal position in Tanystropheidae, and <i>Luxisaurus</i> forms the sister group to a clade consisting of all other tanystropheids. Considering that <i>Fuyuansaurus</i> and <i>Luxisaurus</i> are found exclusively in South China, we hypothesize that Tanystropheidae originated in the Early Triassic of South China and then dispersed globally. The discovery of Early Triassic tanystropheids in South China is needed to further support this hypothesis. The discovery of <i>Luxisaurus</i> expands the stratigraphical and geographical distribution of Tanystropheidae, and provides new insights into the origin and early radiation of the clade. http://zoobank.org/urn:lsid:zoobank.org:pub:07DE12AC-8AE7-48F0-8BAD-0B73F04C0858
DOI: 10.6084/m9.figshare.24230525.v1
title: A new tanystropheid (Diapsida: Archosauromorpha) from the Middle Triassic of SW China and the biogeographical origin of Tanystropheidae

description: Tanystropheidae is a clade of early archosauromorphs with high morphological disparity and a wide geographical distribution. The origin and early radiation of Tanystropheidae are still incompletely understood. Here we report <i>Luxisaurus terrestris</i> gen. et sp. nov., a new archosauromorph collected from the marine Upper Member of Guanling Formation (Pelsonian substage, Anisian, Middle Triassic) in Luxi County, Yunnan Province, China, and phylogenetically recovered as a tanystropheid. The morphology of <i>Luxisaurus</i> is consistent with a terrestrial lifestyle. This is the first occurrence of a tanystropheid found from the Anisian Guanling Formation in SW China and also the earliest tanystropheid from the eastern Tethys. Phylogenetic analysis shows that Dinocephalosauridae forms the sister group of Tanystropheidae, <i>Fuyuansaurus</i> occupies the most basal position in Tanystropheidae, and <i>Luxisaurus</i> forms the sister group to a clade consisting of all other tanystropheids. Considering that <i>Fuyuansaurus</i> and <i>Luxisaurus</i> are found exclusively in South China, we hypothesize that Tanystropheidae originated in the Early Triassic of South China and then dispersed globally. The discovery of Early Triassic tanystropheids in South China is needed to further support this hypothesis. The discovery of <i>Luxisaurus</i> expands the stratigraphical and geographical distribution of Tanystropheidae, and provides new insights into the origin and early radiation of the clade. http://zoobank.org/urn:lsid:zoobank.org:pub:07DE12AC-8AE7-48F0-8BAD-0B73F04C0858
DOI: 10.17632/d74xzc9kz7.1
title: Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin

description: Tables containing all data for figures and graphs included in "Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin." Data labelled by figure and panel.
DOI: 10.17632/mgb7ftwr9d.1
title: Mapping patterns of thought onto brain activity during movie-watching Data and Scripts

description: Data and scripts for Wallace et al., 2024 for reproducibility can be found here. The study set out to map patterns of thought to brain activity during movie watching. 

The research experiment was exploratory in nature - so there were no explicit hypotheses. However, we set out to look at whether or not variations in thought patterns during movie watching, consisting of three 11-minute clips from Citizenfour, Little Miss Sunshine, and 500 Days of Summer, by leveraging a novel sampling technique using multi-dimensional experience sampling (mDES). We were able to accomplish this by using previously-collected fMRI data (n = 44) from the naturalistic neuroimaging database (Aliko et al., 2020) where participants were scanned while watching the films, and using a separate sample of participants (n = 120) to come into the lab to watch the same films and respond to mDES probes. 
 
Our first analysis consisted of a PCA which decomposed the experience sampling data into 4 components of thought. Based on the mDES item loadings, we labelled the thought patterns 'Episodic Knowledge', 'Intrusive Distraction', 'Verbal Detail', and 'Sensory Engagement.' We found that 'Episodic Knowledge' was most reported during 500 Days of Summer, specifically predicted better comprehension performance for this movie, and was related to activity in the visual cortex, specifically in the dorsal medial regions. 'Intrusive Distraction' was associated with reduced activity in the frontoparietal network, was highly reported during Citizenfour, and predicted poorer overall comprehension performance across the movies. 'Verbal Detail' was associated with reduced activity in the auditory cortex, most reported during Citizenfour. Lastly, "Sensory Engagement" was related to multi-modal sensory engagement in auditory and visual cortexes, predicted better overall comprehension performance, and was most highly reported during 500 Days of Summer. These results highlight the critical role that sensory systems play in the multi-modal experience of movie-watching and place important constraints on the contribution of systems in association cortex, like the default network.

The raw mDES data is available, as well as the full dataset with the PCA components, gradient scores and demographic information. The relevant brain maps from the imaging analyses are also included.
DOI: 10.6084/m9.figshare.7453532.v1
title: Additional file 1: of Impact of parental migration on oral health outcomes of left-behind school-aged children in Luchuan, southern China

description: Table S1. Comparisons of oral health-related variables between various experiences of parental migration (NÂ =â 1085). (XLS 33 kb)
DOI: 10.6084/m9.figshare.7453556
title: MOESM2 of Global discovery of small RNAs in the fish pathogen Edwardsiella piscicida: key regulator of adversity and pathogenicity

description: Additional file 2. Differential expression anlysis of sRNAs during three stress condition.
DOI: 10.6084/m9.figshare.7453559
title: MOESM3 of Global discovery of small RNAs in the fish pathogen Edwardsiella piscicida: key regulator of adversity and pathogenicity

description: Additional file 3. Differentially expressed mRNA.
DOI: 10.6084/m9.figshare.7453559.v1
title: MOESM3 of Global discovery of small RNAs in the fish pathogen Edwardsiella piscicida: key regulator of adversity and pathogenicity

description: Additional file 3. Differentially expressed mRNA.
DOI: 10.6084/m9.figshare.7453589
title: Additional file 2: of Genetic ancestry, admixture and health determinants in Latin America

description: Table S2. Lists of pathways that show significant enrichment of genes with mapped ancestry-enriched SNPs for each admixed Latin American population. For each KEGG pathway with significant enrichment of genes with mapped ancestry-enriched SNPs in at least one of the four populations, the overlapping genes and FDR q-values are given. (XLSX 29.6 kb)
DOI: 10.6084/m9.figshare.7453625
title: Additional file 2: of Differential responses of Lasiopodomys mandarinus and Lasiopodomys brandtii to chronic hypoxia: a cross-species brain transcriptome analysis

description: Table S5. DEGs for L. mandarinus and L. brandtii. (XLSX 48 kb)