cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.14654576
title: Title: Harnessing STING Signaling and Natural Killer Cells overcomes PARP Inhibitor Resistance in Homologous Recombination Deficient Breast Cancer

description: Homologous recombination deficiency (HRD) contributes to genomic instability and leads to sensitivity to poly ADP-ribose polymerase inhibitors (PARPi). HRD also activates the cyclic GMP–AMP synthase (cGAS)-STimulator of INterferon Genes (STING)-Interferon (IFN) pathway, highlighting the need to understand the impact of cGAS-STING-IFN signaling on PARPi efficacy. In this study, we analyzed a cohort of thirty-five breast cancer (BC) patient-derived xenografts (PDX) and mouse-derived allografts (MDA). PARPi sensitivity correlated with HRD, increased genomic instability, and activation of the cGAS-STING-IFN signaling pathway. Single-cell analyses showed that IFN signaling and IFN-based immune interactions were suppressed in preclinical models with acquired resistance to PARPi, lacking concomitant clonal expansion of functional CD8+ T cells. However, the combination of PARPi and a novel STING agonist (STINGa) increased immune infiltration and resulted in superior antitumor activity in these tumors. Notably, the efficacy of PARPi monotherapy and the combination treatment with a STINGa was dependent on Natural Killer (NK) cells. In agreement, BC patients with BRCA1/BRCA2 mutations and good responses to PARPi showed higher abundancy of CD56+ NK cells in the tumor microenvironment and treatment-engaged CD56bright NK cells in the peripheral immune compartment, compared to those with poor responses. Therefore, these findings propose the combination of PARPi and STINGa as a potential novel strategy to enhance the therapeutic response in patients with acquired PARPi resistance and highlight a pivotal role of NK cells in the PARPi antitumor activity.
DOI: 10.5281/zenodo.14654577
title: Title: Harnessing STING Signaling and Natural Killer Cells overcomes PARP Inhibitor Resistance in Homologous Recombination Deficient Breast Cancer

description: Homologous recombination deficiency (HRD) contributes to genomic instability and leads to sensitivity to poly ADP-ribose polymerase inhibitors (PARPi). HRD also activates the cyclic GMP–AMP synthase (cGAS)-STimulator of INterferon Genes (STING)-Interferon (IFN) pathway, highlighting the need to understand the impact of cGAS-STING-IFN signaling on PARPi efficacy. In this study, we analyzed a cohort of thirty-five breast cancer (BC) patient-derived xenografts (PDX) and mouse-derived allografts (MDA). PARPi sensitivity correlated with HRD, increased genomic instability, and activation of the cGAS-STING-IFN signaling pathway. Single-cell analyses showed that IFN signaling and IFN-based immune interactions were suppressed in preclinical models with acquired resistance to PARPi, lacking concomitant clonal expansion of functional CD8+ T cells. However, the combination of PARPi and a novel STING agonist (STINGa) increased immune infiltration and resulted in superior antitumor activity in these tumors. Notably, the efficacy of PARPi monotherapy and the combination treatment with a STINGa was dependent on Natural Killer (NK) cells. In agreement, BC patients with BRCA1/BRCA2 mutations and good responses to PARPi showed higher abundancy of CD56+ NK cells in the tumor microenvironment and treatment-engaged CD56bright NK cells in the peripheral immune compartment, compared to those with poor responses. Therefore, these findings propose the combination of PARPi and STINGa as a potential novel strategy to enhance the therapeutic response in patients with acquired PARPi resistance and highlight a pivotal role of NK cells in the PARPi antitumor activity.
DOI: 10.7910/dvn/0fws7c
title: Replication Data for Reservation Wages and the Wage Flexibility Puzzle

description: Replication Files for Reservation Wages and the Wage Flexibility Puzzle, Review of Economics and Statistics
DOI: 10.7910/dvn/0een6y
title: China Zero-Covid Risk Level Dataset

description: This dataset records the county-level COVID-19 risk levels from April 2, 2021, to December 15, 2022, with daily frequency. The data was sourced from the Chinese State Council’s public website for COVID-19 risk levels (the original site is no longer active). Risk levels are categorized into three classes: high risk, medium risk, and low risk.

Until July 21, 2022, only regions designated as medium or high risk were publicly listed, with all other areas classified as low risk. From July 21 to November 15, 2022, the website expanded to include low-risk areas as well, marking all other regions as under “normal preventive control.” Starting November 15, 2022, only high-risk and low-risk regions were listed, with other areas still under normal preventive control. For details on these adjustments in risk definitions, please refer to related policy documents and reports.

The dataset includes binary status variables for both high_risk and mid_risk levels, where a value of 1 indicates that a county contains at least one area classified as high or medium risk, respectively. Please note that a county may simultaneously contain both high- and medium-risk areas, resulting in both high_risk and mid_risk being marked as 1.

This dataset has been cleaned to the county level, though the original data included some street-level information. Researchers interested in the original finer-level details should contact the authors directly.

The dataset, along with additional notes, is available at: https://github.com/dadasmash/China_COVID_Risk_Level_Dataset/tree/master

For further details on the dataset’s structure, please refer to the original publication. If you utilize this dataset, please cite:

 • Da Gong, Zhuocheng Shang, Yaqin Su, Andong Yan, Qi Zhang, “Economic impacts of China’s zero-COVID policies,” China Economic Review, Volume 83, 2024, 102101, ISSN 1043-951X, https://doi.org/10.1016/j.chieco.2023.102101.

Contributors: Da Gong, Andong Yan, Qi Zhang
DOI: 10.7910/dvn/0lkajx
title: Replication Data for: A Shadow on Democracy? The Shadow Economy and Government Responsiveness

description: Data and replication files (Stata).
DOI: 10.7910/dvn/0gbsqa
title: Papers included in the manuscript entitled "A review of the application of ensemble forecast approach in the fields beside meteorology".

description: Papers included in the manuscript entitled "A review of the application of ensemble forecast approach in the fields beside meteorology".
DOI: 10.7910/dvn/0kmzml
title: Prospects of core–edge integrated no-ELM and small-ELM scenarios for future fusion devices

description: One of our grand challenges towards fusion energy is the achievement of a high-performance plasma core coupled to a boundary solution. The high confinement mode (H-mode) provides such a high-performance fusion core due to the build-up of an edge transport barrier leading to a pedestal. However, it usually features type-I edge localized modes (ELMs) which pose a threat for long-duration plasma operation in future fusion devices as they induce large energy fluences onto the plasma facing components and typically are projected to damage the first wall. For future fusion devices, the integration of a stationary no-ELM regime with a power exhaust solution is indis- pensable. Several no-ELM and small-ELM regimes have extended their operational space in the past years, with the ultimate goal of providing an alternative core-edge solution to ITER and EU-DEMO. Prominent no-ELM or small-ELM alternatives include the I-mode, QH-mode, EDA H-mode, quasi-continuous exhaust (QCE) and ‘grassy’ ELM regimes, X-point radiator scenarios and negative triangularity L-mode. The state-of-the-art, including access conditions and main signatures, of these alternative regimes is reviewed. Many of these regimes partly match the operational space of ITER and EU-DEMO, however, knowledge gaps remain. Besides compatibility with divertor detachment and a radiative mantle, these include extrapolations to high Q operations, low core collisionality, high Greenwald fractions, impurity transport, amongst others. The knowledge gaps and possible strategies to close these gaps to show their applicability to ITER and EU-DEMO are discussed.
description: PSFC REPORT PSFC/JA-22-106<br><br>A. E. H. and J. W. H. gratefully acknowledge funding from the US DoE Award DE-SC0014264.<br><br>If this record does not contain the full text, then the manuscript has been embargoed by the publisher thus restricting open access for 12 to 24 months after publication.
DOI: 10.7910/dvn/0lndky
title: Replication Data for: State Capacity during Crisis
title: Exploring varieties of state capacity in the COVID-19 pandemic

description: This article examines coercive state responses during COVID-19 as one option among several types of state capacity that may be mobilized in times of crisis. While states respond to crises with their available capacity, strategies change over time, especially as deploying coercive capacities can be costly. We use variables from the CoronaNet Research Project, an original dataset of over 170,000 policy entries from 195 countries, including nearly 26,000 policies on Russia to show timing and substitution effects where different types of state capacity were leveraged in different policy arenas and at different times in the pandemic.
DOI: 10.7910/dvn/0jfd6u
title: Main_Matlab_codes

description: Main codes
DOI: 10.7910/dvn/0qbun8
title: CMC Competency and AI

description: This data collected from a population of undergraduate students describes their attitudes and use of generative AI in an online classroom.
DOI: 10.7910/dvn/0vlpvp
title: Data for: Integrative Taxonomy Approach Reveals a New Species of Fomitiporia (Hymenochaetaceae) for Brazilian Funga

description: DNA matrices for the phylogenetic analyses and resulting trees.
DOI: 10.7910/dvn/0tkkmp
title: Replication Data for: Network Context and the Effectiveness of International Agreements

description: Why do some international agreements yield more cooperation than others? I argue that the network context of agreements conditions their effectiveness. I focus on bilateral defense cooperation agreements (DCAs), which promote defense activities like joint military exercises, peacekeeping, arms trade, and the sharing of classified information. Because DCAs emphasize ongoing cooperative actions, they offer an ideal setting to assess treaty effectiveness. The analysis shows that when agreements are embedded in transitive “friend of friend” relations, characterized by extensive ties to common third parties, they generate higher levels of cooperation. I argue that this network effect is the result of policy convergence. When states share ties with common third parties, their own policies become more closely aligned, and this alignment in turn reduces the costs and increases the benefits of cooperative actions. The theory and findings developed here apply to a wide array of cooperative interactions across multiple issue areas. The effectiveness of international agreements depends on network context.
DOI: 10.7910/dvn/0rgyw8
title: Replication Data for: Figures in The Impact of 2022 Hunga Tonga-Hunga Ha’apai (Hunga) Eruption on Stratospheric Circulation and Climate

description: Dataset used to generate figures in "Disentangling The Impact of 2022 Hunga Tonga-Hunga Ha’apai (HTHH) Eruption on the Stratospheric Circulation and Climate"
DOI: 10.7910/dvn/0snrbw
title: Replication Data for: Examining the extent of compliance on combined assurance reporting quality: Evidence from Namibian state-owned enterprises

description: The annual/integrated reports data are publicly available.
description: Data is also available at: https://data.mendeley.com/datasets/mjrw5v7gp3/1
DOI: 10.7910/dvn/0vb42v
title: Performance and cost-benefit analysis data for three hatcheries operating as businesses in Timor-Leste.

description: These datasets include (a) hatchery performance data, such as egg production, fry survival rates, and monosex fry output, and (b) economic data on hatchery investments and operational costs, including capital expenditures, feed costs, and labor costs, as well as revenue from broodfish and monosex fry sales.
description: Type: Dataset; Sub-type(s): Other (Aquaculture, food and nutrition security)
DOI: 10.7910/dvn/0trhtg
title: Replication Data for: Social influencers and election outcomes

description: Replication Data for Social Influencers and Election Outcomes
DOI: 10.7910/dvn/0tseqv
title: PDB: 6UMT, Crystal structure of human PD-1: PD-L2 complex (313K, 40°C, 500 ns) - random seed #2, RMSD, SASA, RMSF, Rg, H-bonds.

description: PDB: 6UMT, Crystal structure of human PD-1: PD-L2 complex (313K, 40°C, 500 ns) - random seed #2, RMSD, SASA, RMSF, Rg, H-bonds..
DOI: 10.34740/kaggle/dsv/11954947
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.7910/dvn/19hf6q
title: Output Data for "A dry Venusian interior constrained by atmospheric chemistry"

description: Chemical profiles, reaction rates, and chemical network used to evaluate the fluxes in the Venusian atmosphere.
DOI: 10.7910/dvn/0y8put
title: Research protocols for the UNRF project

description: Protocols for data collection in the UNRF project:
1. Interview guidelines
2. Codebook used for coding the interviews
DOI: 10.7910/dvn/0zalol
title: Replication Data for: The surge of illiberal politics in Southern Europe: the case of Vox (Spain) and Chega (Portugal) (forthcoming)

description: Data and instructions for the analysis performed in Return of History or ex-novo politics? A computational institutionalist perspective on the surge of Vox in Spain and Chega in Portugal. (forthcoming)
description: accepted, forthcoming
DOI: 10.7910/dvn/0x8v9c
title: vitd_TSH_FT4_TPO_groups_Laghouat_dataset

description: this is the dataset used in the research article titled" The Impact of Vitamin D Deficiency on Autoimmune Thyroid Dysfunction in Hashimoto's Disease: Evidence from a Cohort Study in Laghouat, Algeria"
DOI: 10.7910/dvn/0xxfqi
title: [Dataset] Media Coverage of Lobby Groups in Spain's Digital Press

description: [Dataset] Media Coverage of Lobby Groups in Spain's Digital Press
DOI: 10.7910/dvn/19tcxp
title: Replecation RESL Data for Rea, Merten, and Rife (2024) Nature Sustainability

description: These are the RESL ELD data used in Rea, Merten, and Rife (2024) Nature Sustainability.
DOI: 10.5281/zenodo.15516117
title: paple2 Galaxy data file

description: Here is a summary of the galaxy fitting files for the second paper "Zero-Parameter Fractal Gravity Beats Dark Halos in All 175 SPARC Disc Galaxies: A Comprehensive Analysis".
DOI: 10.5281/zenodo.15516118
title: paple2 Galaxy data file

description: Here is a summary of the galaxy fitting files for the second paper "Zero-Parameter Fractal Gravity Beats Dark Halos in All 175 SPARC Disc Galaxies: A Comprehensive Analysis".
DOI: 10.7910/dvn/0zai8o
title: Replication Data for: Impacts into Titan's methane-clathrate crust as a source of atmospheric methane

description: This dataset contains input and output files of iSALE for the paper "Impacts into Titan's methane-clathrate crust as a source of atmospheric methane" by S. Wakita et al.
DOI: 10.7910/dvn/11spcz
title: EPAC study

description: Data set to replicate the study
DOI: 10.7910/dvn/12d49o
title: Datasets for Predicting survival in patients with SARS-CoV-2 infection based on soluble immune checkpoint regulators and cytokines

description: Predicting survival in patients with SARS-CoV-2 infection based on soluble immune checkpoint regulators and cytokines
DOI: 10.7910/dvn/10fmmw
title: Replication Data for: "How do Masses React to Party Polarization? Limited Effect of Party Polarization on Mass Polarization"

description: Elite ideological polarization is rising in Western democracies. Is this elite ideological polarization associated with mass ideological polarization? I argue that when a party adopts a more extreme position, the masses polarize via two mechanisms. In-partisans should follow the party and adopt a more extreme ideological stance while out-partisans should backlash and move in the opposite direction. To test these expectations, I exploit a real-world sudden party polarization when the Labour Party of the United Kingdom suddenly shifted to the left under new leadership. Using British Election Study Internet Panel data, I find limited evidence that elite polarization leads to mass polarization. Overall, neither in-partisans followed the party, nor out-partisans backlashed to it. Only ideologically out-of-touch in-partisans adjusted their ideological stance to match their party, indicating the effectiveness of partisan cues, nonetheless. These findings provide insight into how the masses react to increasing party polarization, alleviating pundits' concerns that the masses are blind followers and bound to polarize if political parties polarize.
DOI: 10.7910/dvn/1iehza
title: Replication Data for: Technological Waves, Knowledge Diffusion, and Local Growth

description: This is the replication package for "Technological Waves, Knowledge Diffusion, and Local Growth" accepted in 2024 by the Journal of Political Economy Macroeconomics
DOI: 10.7910/dvn/1iia0c
title: Replication Data for: American views about election fraud in 2024

description: Replication data for American views about election fraud in 2024.
DOI: 10.7910/dvn/1klbmd
title: Male role norms and development of PTSD among Polish male paramedics

description: male paramedics database
DOI: 10.7910/dvn/12ytin
title: Replication Data for: "Family Law Effects on Divorce, Fertility and Child Investment"

description: This is the replication package for "Family Law Effects on Divorce, Fertility and Child Investment," accepted in 2024 by the Journal of Labor Economics.
DOI: 10.7910/dvn/18ktpn
title: Replication Data for: Migration discourses from the radical right: Mapping and testing potential for political mobilization

description: Raw data, codebook and replication scritp in R for the study "Migration discourses from the radical right: Mapping and testing potential for political mobilization"
DOI: 10.7910/dvn/19vofu
title: Data for: Whole blood immune gene expression analysis in Angus bulls with divergent residual feed intake EPD

description: The supplementary material contains data used for the publication "Whole blood immune gene expression analysis in Angus bulls with divergent residual feed intake EPD". This manuscript examines the mRNA expression profiles of immune-related
genes in bulls with either negative or positive RFI-EPDs.
DOI: 10.7910/dvn/1eyypl
title: Village Establishment Data for Ebolavirus evolution and emergence are associated with land use change

description: This data contains the date of establishment of villages surveyed in Northern DRC during 2016 and 2017.
DOI: 10.7910/dvn/1obf25
title: Harper Adams University Future Farm main dairy production data 2018-date

description: Future Farm, Dairy, Research, Teaching, Global Farm Platform, Regression, ANOVA, multivariate

The Harper Adams University Future Farm Main Dairy Unit operates commercially as a platform for teaching and research, accommodating 400 cows milked in a 40-point GEA rotary parlour with automated cow identification, recording milk yields, and monitoring activity for oestrus detection. The target yield is 10,000 litres per cow annually, achieved with thrice-daily milking. The internal circular parlour design facilitates cow monitoring and teaching, with additional features including a viewing gallery and modern housing. The unit comprises two ventilated cow buildings: one with cubicles and another with cubicles and straw yards, incorporating automated systems such as ventilation screens, feed drones, and slurry scrapers. The Cow Manager system monitors cow health metrics, while Bovisync provides cloud-based data access, supporting student activities from undergraduate sessions to PhD projects.
DOI: 10.7910/dvn/1nnqwb
title: Replication Data for: "Rural land prices with insecure property rights"

description: This dataset contains the replication data for the paper Rural Land Prices with Insecure Property rights. The data was downloaded from different public sources from the Colombian Government, including the National Planning Department (DNP), the Ministry of Agriculture and the National Statistics Department (DANE). Observations correspond to land-size brackets at the municipal level for 200 different municipalities.
DOI: 10.7910/dvn/1f7cik
title: Replication Data for The Impact of an Adult Education Program on Mothers: Evidence from India

description: The replication folder has STATA do-files and datasets to replicate all the analyses done in the paper The Impact of an Adult Education Program on Mothers: Evidence from India.
DOI: 10.7910/dvn/1tfzf9
title: [COMPLEMENTOS] Conocimiento del profesorado de Matemáticas en formación inicial en las áreas de geometría y trigonometría: una revisión bibliográfica sistematizada

description: Esta base contiene versiones en formato de documentos portátiles –PDF– del protocolo de búsqueda, el formato de las fichas bibliográficas y un ejemplo de estas últimas, bases de realización de una revisión bibliográfica sistematizada sobre los conocimientos del profesorado de Matemáticas en formación inicial.

La intencionalidad y funcionalidad de estos instrumentos, así como los resultados de la revisión bibliográfica puede consultarse en: Cruz-Márquez, G. y Montiel-Espinosa, G. (2024). Conocimiento del profesorado de Matemáticas en formación inicial en las áreas de geometría y trigonometría: una revisión bibliográfica sistematizada. Perspectiva Educacional, 63(3), 214–240. https://doi.org/10.4151/07189729-Vol.63-Iss.3-Art.1465
DOI: 10.7910/dvn/1lxmyj
title: Replication Data for: Decoding consumer sentiments: advanced NLP techniques for analyzing smartphone reviews

description: Decoding Consumer Sentiments: Advanced NLP Techniques for Analyzing Smartphone Reviews: datasets and codes used in the research.
DOI: 10.7910/dvn/1qmlov
title: Replication Data for: News Sharing on Social Media: Mapping the Ideology of News Media, Politicians, and the Mass Public

description: This article examines the information sharing behavior of US politicians and the mass public by mapping the ideological sharing space of political news on social media. As data, we use the near-universal currency of online information exchange: web links. We introduce a methodological approach and software to unify the measurement of ideology across social media platforms by using sharing data to jointly estimate the ideology of news media organizations, politicians, and the mass public. Empirically, we show that (1) politicians who share ideologically polarized content share, by far, the most political news and commentary, and (2) that the less competitive elections are, the more likely politicians are to share polarized information. These results demonstrate that news and commentary shared by politicians come from a highly unrepresentative set of ideologically extreme legislators, and that decreases in election pressures (e.g. by gerrymandering) may encourage polarized sharing behavior.