cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.57702/b19fan4l
title: C-GQA

description: The C-GQA dataset is a large-scale dataset for compositional zero-shot learning, containing 413 attributes and 674 objects.
DOI: 10.57702/b8nunyvp
title: LUT-NN: Empower Efficient Neural Network Inference with Centroid Learning and Table Lookup

description: The dataset used in the paper is not explicitly described. However, it is mentioned that the authors used a range of datasets, including CIFAR-10, GTSRB, Google Speech Command, SVHN, UTKFace, and ImageNet.
DOI: 10.15468/dl.7s4733
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Begonia tayabensis Merr.)"
 ]
}

 The dataset includes 28 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013011-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57702/tyezjqav
title: BIKED: A dataset and machine learning benchmarks for data-driven bicycle design

description: BIKED—a dataset of bicycle models–is organized and curated specifically for data-driven design of bicycles. Data is sourced from a rich archive of CAD files from the specialized BikeCAD software, which is primarily used by professional frame designers and bicycle enthusiasts.
DOI: 10.57702/we1ow31g
title: Merlin

description: The dataset used in the paper is a collection of trajectories for goal-conditioned reinforcement learning tasks.
DOI: 10.57702/22jeabcl
title: Cross-Modal Implicit Relation Reasoning and Aligning for Text-to-Image Person Retrieval

description: Text-to-image person retrieval aims to identify the target person based on a given textual description query.
DOI: 10.57702/3gbryqh8
title: CUHK-PEDES

description: Text-based person search aims to retrieve the corresponding person images from the given image database by virtue of a describing sentence about the person.
DOI: 10.57702/bofk589j
title: COPES

description: The COPES dataset is a benchmark for event causality extraction. It contains 340 stories and 1360 event pairs.
DOI: 10.57702/8jxkbhjg
title: GLUCOSE

description: GLUCOSE is a large-scale dataset of implicit commonsense knowledge, encoded as causal mini-theories about the world, each grounded in a narrative context.
DOI: 10.15468/dl.7rz7cp
title: Occurrence Download

description: A dataset containing 3369 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-9.47354 41.71959,-6.12028 41.71959,-6.12028 43.95209,-9.47354 43.95209,-9.47354 41.71959))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Eucalyptus globulus Labill."
 ]
}

 The dataset includes 3369 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013010-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57702/aac1cr15
title: IBSR dataset

description: The dataset used for brain tissue segmentation in MRI images
DOI: 10.57702/5o7io9lm
title: MRBrainS dataset

description: The dataset used for brain tissue segmentation in MRI images
DOI: 10.15468/dl.3kjpm5
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hippoglossus grigorjewi Herzenstein, 1890",
 "Geometry POLYGON((170 20, 170 50, 120 50, 120 20, 170 20))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013012-241126133413365/datasets/export for details.
DOI: 10.57702/m7thgtce
title: STU

description: A dataset of 42 breast ultrasound images acquired by Shantou University using the GE Voluson E10 ultrasonic diagnostic system.
DOI: 10.57702/h153jf39
title: Development of a physical 3D anthropomorphic breast phantom

description: A physical 3D anthropomorphic breast phantom.
DOI: 10.57702/h8c6mjle
title: The Open-Source Virtual Clinical Trial Project

description: A virtual clinical trial framework.
DOI: 10.57702/rf6o3qk2
title: DeepPocket

description: Portfolio management aims at maximizing the return on investment while minimizing risk by continuously reallocating the assets forming the portfolio. These assets are not independent but correlated during a short time period.
DOI: 10.57702/9vg56hsm
title: Computer Vision for Medical Infant Motion Analysis

description: A dataset for computer vision for medical infant motion analysis: state of the art and RGB-D data set.
DOI: 10.57702/3v1236lu
title: Invariant Representation Learning for Infant Pose Estimation

description: Invariant representation learning for infant pose estimation with small data.
DOI: 10.15468/dl.unvv2r
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Begonia tenuibracteata C.I Peng, Rubite & C.W.Lin)"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013015-241126133413365/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57702/hgdxvl8z
title: IWSLT14 EN→DE, WMT14 EN→DE, WMT16 EN→DE

description: The dataset used in the paper is not explicitly described. However, it is mentioned that the authors used the IWSLT14 EN→DE task, WMT14 EN→DE task, and WMT16 EN→DE task.
DOI: 10.57702/7yg6k69l
title: Mono-ViFI: A Unified Framework for Self-supervised Monocular Depth Estimation

description: Self-supervised monocular depth estimation has gathered no-table interest since it can liberate training from dependency on depth annotations. In monocular video training case, recent methods only conduct view synthesis between existing camera views, leading to insuffi-cient guidance. To tackle this, we try to synthesize more virtual camera views by flow-based video frame interpolation (VFI), termed as tempo-ral augmentation.
DOI: 10.15468/dl.hfydpx
title: Occurrence Download

description: A dataset containing 220974 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Belgium",
 "TaxonKey is one of (Aponogeton distachyos L.f., Arthurdendyus triangulatus (Dendy, 1895), Cabomba caroliniana A.Gray, Callosciurus finlaysonii (Horsfield, 1823), Cherax destructor Clark, 1936, Corvus splendens Vieillot, 1817, Crassula helmsii (Kirk) Cockayne, Elodea densa (Planch.) Casp., Eriocheir sinensis H.Milne Edwards, 1853, Erythranthe guttata (DC.) G.L.Nesom, Faxonius immunis (Hagen, 1870), Faxonius juvenilis (Hagen, 1870), Faxonius rusticus (Girard, 1852), Faxonius virilis (Hagen, 1870), Gambusia affinis (Baird & Girard, 1853), Heracleum mantegazzianum Sommier & Levier, Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall., Heracleum pubescens (Hoffm.) M.Bieb., Houttuynia cordata Thunb., Hydrocotyle ranunculoides L.f., Impatiens glandulifera Royle, Koenigia polystachya (Wall. ex Meisn.) T.M.Schust. & Reveal, Lagarosiphon major (Ridl.) Moss, Lepomis gibbosus (Linnaeus, 1758), Limnoperna fortunei (Dunker, 1857), Ludwigia grandiflora (Michx.) Greuter & Burdet, Ludwigia peploides (Kunth) P.H.Raven, Lysichiton americanus Hultén & H.St.John, Morone americana (Gmelin, 1789), Muntiacus reevesi (Ogilby, 1839), Myriophyllum aquaticum (Vell.) Verdc., Myriophyllum heterophyllum Michx., Pacifastacus leniusculus (Dana, 1852), Petasites japonicus (Siebold & Zucc.) Maxim., Pontederia cordata L., Procambarus acutus (Girard, 1852), Procambarus clarkii (Girard, 1852), Procambarus virginalis Lyko, 2017, Pseudorasbora parva (Temminck & Schlegel, 1846), Pycnonotus cafer (Linnaeus, 1766), Saururus cernuus L., Sciurus carolinensis Gmelin, 1788, Sciurus niger Linnaeus, 1758, Solenopsis invicta Buren, 1972, Solenopsis richteri Forel, 1909, Threskiornis aethiopicus (Latham, 1790), Vespa velutina Lepeletier, 1836, Zizania latifolia (Griseb.) Hance ex F.Muell.)",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 2000"
 ]
}

 The dataset includes 220974 records from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009099-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3hvd6k
title: Occurrence Download

description: A dataset containing 41 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (EOD – eBird Observation Dataset, iNaturalist Research-grade Observations, Observation.org, Nature data from around the World)",
 "Geometry POLYGON((-75.02237 -27.31336,-75.12363 -29.82055,-71.04775 -29.84943,-70.61132 -26.70866,-74.76161 -26.27113,-75.02237 -27.31336))",
 "HasGeospatialIssue is false",
 "TaxonKey is Tursiops truncatus (Montagu, 1821)"
 ]
}

 The dataset includes 41 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009112-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dtce53
title: Occurrence Download

description: A dataset containing 118 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Mystacinidae"
 ]
}

 The dataset includes 118 records from 25 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009113-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qwzxx9
title: Occurrence Download

description: A dataset containing 658477 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Xestia c-nigrum (Linnaeus, 1758)",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 658477 records from 636 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009100-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.chuh2j
title: Occurrence Download

description: A dataset containing 166 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myzopodidae"
 ]
}

 The dataset includes 166 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009043-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w3rwyk
title: Occurrence Download

description: A dataset containing 137 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Xyleborinus attenuatus (Blandford, 1894) Blandford",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 137 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009044-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r3qf9k
title: Occurrence Download

description: A dataset containing 457704 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phyllostomidae"
 ]
}

 The dataset includes 457704 records from 690 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009110-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.r3uktx
title: Occurrence Download

description: A dataset containing 8403 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Natalidae"
 ]
}

 The dataset includes 8403 records from 149 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009047-250227182400228/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jfj7wg
title: Occurrence Download

description: A dataset containing 57 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (EOD – eBird Observation Dataset, iNaturalist Research-grade Observations, Observation.org, Nature data from around the World)",
 "Geometry POLYGON((-75.02237 -27.31336,-75.12363 -29.82055,-71.04775 -29.84943,-70.61132 -26.70866,-74.76161 -26.27113,-75.02237 -27.31336))",
 "HasGeospatialIssue is false",
 "TaxonKey is Lontra felina (Molina, 1782)"
 ]
}

 The dataset includes 57 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009115-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x9tk3w
title: Occurrence Download

description: A dataset containing 277 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brazil",
 "TaxonKey is Swietenia macrophylla G.King"
 ]
}

 The dataset includes 277 records from 77 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009116-250227182430271/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qxu83s
title: Occurrence Download

description: A dataset containing 20283 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Country is Peru",
 "TaxonKey is Fulica ardesiaca Tschudi, 1843"
 ]
}

 The dataset includes 20283 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071021-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.txp5hz
title: Occurrence Download

description: A dataset containing 11796 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cynoglossum officinale L., Cynosurus echinatus L., Cyperus eragrostis Lam., Cyperus esculentus L., Cyperus fuscus L., Cyperus longus L., Cyperus serotinus Rottb., Cytisophyllum sessilifolium (L.) O.Lang, Cytisus scoparius (L.) Link, Dactylis glomerata L., Dactylorhiza maculata (L.) Soó, Dactylorhiza majalis (Rchb.) P.F.Hunt & Summerh., Danthonia decumbens (L.) DC., Danthonia spicata (L.) Roem. & Schult., Daphne gnidium L., Daphne laureola L., Daphne mezereum L., Datura ferox L., Datura stramonium L., Daucus carota L., Delairea odorata Lem., Delphinium consolida L., Descurainia sophia (L.) Webb ex Prantl, Dianella tasmanica Hook.f., Dianthus armeria L., Dianthus carthusianorum L., Dianthus deltoides L., Dicksonia antarctica Labill., Digitalis grandiflora Mill., Digitalis lutea L., Digitalis purpurea L., Digitaria ischaemum (Schreb.) Muhl., Digitaria sanguinalis (L.) Scop., Dioscorea communis (L.) Caddick & Wilkin, Diplotaxis erucoides (L.) DC., Diplotaxis muralis (L.) DC., Diplotaxis tenuifolia (L.) DC., Dipsacus fullonum L., Disa bracteata Sw., Dittrichia graveolens (L.) Greuter, Doronicum pardalianches L., Draba verna L., Drosera intermedia Hayne, Drosera rotundifolia L., Dryopteris affinis (Lowe) Fraser-Jenk., Dryopteris carthusiana (Vill.) H.P.Fuchs, Dryopteris dilatata (Hoffm.) A.Gray, Dryopteris filix-mas (L.) Schott, Dysphania ambrosioides (L.) Mosyakin & Clemants, Dysphania pumilio (R.Br.) Mosyakin & Clemants, Ecballium elaterium (L.) A.Rich., Echinochloa crus-galli (L.) P.Beauv., Echinochloa muricata (P.Beauv.) Fernald, Echinochloa oryzoides (Ard.) Fritsch, Echinocystis lobata (Michx.) Torr. & A.Gray, Echinops ritro L., Echinops sphaerocephalus L., Echium plantagineum L., Echium vulgare L., Ehrharta calycina Sm., Ehrharta erecta Lam., Ehrharta longiflora Sm., Elaeagnus angustifolia L., Elaeagnus umbellata Thunb., Eleocharis acicularis (L.) Roem. & Schult., Eleocharis multicaulis (Sm.) Desv., Eleocharis palustris (L.) Roem. & Schult., Eleocharis uniglumis (Link) Schult., Eleusine indica (L.) Gaertn., Elodea canadensis Michx., Elodea densa (Planch.) Casp., Elymus caninus (L.) L., Elymus pungens (Pers.) Melderis, Elymus repens (L.) Gould, Epacris impressa Labill.)",
 "Country is New Zealand",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence, Material citation, Living Specimen)",
 "CoordinateUncertaintyInMeters is less than or equal to 10000",
 "HasCoordinate is true"
 ]
}

 The dataset includes 11796 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071022-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u9ygd9
title: Occurrence Download

description: A dataset containing 5779 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epilobium ciliatum Raf., Epilobium hirsutum L., Epilobium montanum L., Epilobium obscurum Schreb., Epilobium parviflorum Schreb., Epilobium roseum (Schreb.) Schreb., Epilobium tetragonum L., Epipactis atrorubens (Hoffm.) Besser, Epipactis helleborine (L.) Crantz, Epipactis palustris (L.) Crantz, Equisetum arvense L., Equisetum hyemale L., Equisetum ramosissimum Desf., Equisetum telmateia Ehrh., Eragrostis cilianensis (All.) Vignolo ex Janch., Eragrostis curvula (Schrad.) Nees, Eragrostis minor Host, Eragrostis multicaulis Steud., Eragrostis pilosa (L.) P.Beauv., Eranthis hyemalis (L.) Salisb., Erechtites hieraciifolius (L.) Raf. ex DC., Erica arborea L., Erica australis L., Erica cinerea L., Erica multiflora L., Erica scoparia L., Erica tetralix L., Erica vagans L., Erigeron annuus (L.) Pers., Erigeron bonariensis L., Erigeron canadensis L., Erigeron floribundus (Kunth) Sch.Bip., Erigeron karvinskianus DC., Erigeron philadelphicus L., Erigeron sumatrensis Retz., Erinacea anthyllis Link, Erinus alpinus L., Erodium botrys (Cav.) Bertol., Erodium cicutarium (L.) L'Hér., Erodium moschatum (L.) L'Hér., Eryngium campestre L., Eryngium maritimum L., Erysimum cheiranthoides L., Erysimum cheiri (L.) Crantz, Erythranthe guttata (DC.) G.L.Nesom, Erythranthe lutea (L.) G.L.Nesom, Erythronium americanum Ker Gawl., Erythronium dens-canis L., Eschscholzia californica Cham., Eucalyptus albens Miq., Eucalyptus amygdalina Labill., Eucalyptus blakelyi Maiden, Eucalyptus camaldulensis Denham, Eucalyptus cladocalyx F.Muell., Eucalyptus cypellocarpa L.A.S.Johnson, Eucalyptus delegatensis F.Muell. ex R.T.Baker, Eucalyptus dives Schauer, Eucalyptus globulus Labill., Eucalyptus leucoxylon F.Muell., Eucalyptus melliodora A.Cunn. ex Schauer, Eucalyptus microcarpa (Maiden) Maiden, Eucalyptus obliqua L'Hér., Eucalyptus ovata Labill., Eucalyptus pauciflora Sieber ex Spreng., Eucalyptus radiata A.Cunn. ex DC., Eucalyptus sieberi L.A.S.Johnson, Eucalyptus viminalis Labill., Euonymus europaeus L., Euonymus fortunei (Turcz.) Hand.-Mazz., Eupatorium cannabinum L., Euphorbia amygdaloides L., Euphorbia characias L., Euphorbia cyparissias L., Euphorbia dulcis L., Euphorbia esula L.)",
 "Country is New Zealand",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence, Material citation, Living Specimen)",
 "CoordinateUncertaintyInMeters is less than or equal to 10000",
 "HasCoordinate is true"
 ]
}

 The dataset includes 5779 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071023-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wvc5re
title: Occurrence Download

description: A dataset containing 6136 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Euphorbia exigua L., Euphorbia helioscopia L., Euphorbia lathyris L., Euphorbia maculata L., Euphorbia myrsinites L., Euphorbia nicaeensis All., Euphorbia palustris L., Euphorbia paralias L., Euphorbia peplus L., Euphorbia platyphyllos L., Euphorbia seguieriana Neck., Euphorbia stricta L., Euphrasia officinalis L., Euphrasia stricta J.P.Wolff ex J.F.Lehm., Euthamia graminifolia (L.) Nutt., Fagopyrum esculentum Moench, Fagopyrum tataricum (L.) Gaertn., Fagus sylvatica L., Fallopia baldschuanica (Regel) Holub, Fallopia convolvulus (L.) Á.Löve, Fallopia dumetorum (L.) Holub, Festuca alopecuros Schousb., Festuca altissima All., Festuca ambigua Le Gall, Festuca bromoides L., Festuca filiformis Pourr., Festuca heterophylla Lam., Festuca lachenalii (C.C.Gmel.) Spenn., Festuca myuros L., Festuca nigrescens Lam., Festuca ovina L., Festuca rubra L., Ficaria verna Huds., Ficus carica L., Filago germanica L., Filago pyramidata L., Filipendula ulmaria (L.) Maxim., Filipendula vulgaris Moench, Fissidens taxifolius Hedw., Foeniculum vulgare Mill., Frangula alnus Mill., Fraxinus angustifolia Vahl, Fraxinus excelsior L., Fraxinus ornus L., Fraxinus pennsylvanica Marshall, Fritillaria meleagris L., Fuchsia magellanica Lam., Fumana procumbens (Dunal) Gren. & Godr., Fumaria capreolata L., Fumaria densiflora DC., Fumaria muralis Koch, Fumaria officinalis L., Gagea lutea (L.) Ker Gawl., Galanthus nivalis L., Galega officinalis L., Galeopsis bifida Boenn., Galeopsis ladanum L., Galeopsis segetum Neck., Galeopsis speciosa Mill., Galeopsis tetrahit L., Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz & Pav., Galium album Mill., Galium aparine L., Galium lucidum All., Galium mollugo L., Galium odoratum (L.) Scop., Galium palustre L., Galium parisiense L., Galium spurium L., Galium sylvaticum L., Galium tricornutum Dandy, Galium uliginosum L., Galium verum L., Gamochaeta americana (Mill.) Wedd.)",
 "Country is New Zealand",
 "BasisOfRecord is one of (Human Observation, Observation, Occurrence evidence, Material citation, Living Specimen)",
 "CoordinateUncertaintyInMeters is less than or equal to 10000",
 "HasCoordinate is true"
 ]
}

 The dataset includes 6136 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071024-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29381517
title: Neural dysfunction, inflammatory disorder, and metabolic interference feature in amantadine-related adverse drug events: a perspective from FAERS and network toxicology

description: Adverse drug events (ADEs) related to amantadine gradually increase as the drug is broadly acknowledged for remission of Parkinson’s disease or Parkinsonism. The ADEs vary according to the affected organs and the potential mechanisms remain elusive. We mined data from the FAERS Database and employed network toxicology to appraise amantadine-related ADEs and dissect the toxicological mechanisms. We found 1,917 ADE reports relevant to amantadine that embodied 1,871 intense-signal ADEs (implicating 134 preferred terms (PTs)). Of those PTs, 69 were undeclared in current amantadine insert. System organ class (SOC) term-based analysis showed that PDGFRB, STAT3, and PRKCD, as well as the enriched pathways such as Neuroactive ligand – receptor interaction and Toll-like receptor signaling pathway were instrumental in amantadine-related Death outcome. Toxicological analysis for the representative undeclared ADEs showed that the toxic targets like STAT3, MAPK1, and CYP3A4 played central roles in amantadine toxicity and adverse events. Molecular docking revealed high-affinity binding of amantadine to MAPK1, MAPK3, HSP90AA1, CYP3A4, and CYP2C19 which were involved in neural function, inflammation, and metabolism. The mechanisms underlying amantadine-related ADEs allow new insights into pharmacovigilance for amantadine use.