cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11804283.v1
title: Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats

description: Abstract Objective: The phytohormone abscisic acid (ABA) as a signaling molecule exists in various types of organisms from early multicellular to animal cells and tissues. It has been demonstrated that ABA has an antinociceptive effect in rodents. The present study was designed to assess the possible role of PKA and phosphorylated ERK (p-ERK) on the antinociceptive effects of intrathecal (i.t.) ABA in male Wistar rats. Methods: The animals were cannulated intrathecally and divided into different experimental groups (n=6‒7): Control (no surgery), vehicle (received ABA vehicle), ABA-treated groups (received ABA in doses of 10 or 20 µg/rat), ABA plus H.89 (PKA inhibitor)-treated group which received the inhibitor 15 min prior to the ABA injection. Tail-flick and hot-plate tests were used as acute nociceptive stimulators to assess ABA analgesic effects. p-ERK was evaluated in the dorsal portion of the spinal cord using immunoblotting. Results: Data showed that a microinjection of ABA (10 and 20 µg/rat, i.t.) significantly increased the nociceptive threshold in tail flick and hot plate tests. The application of PKA inhibitor (H.89, 100 nM/rat) significantly inhibited ABA-induced analgesic effects. Expression of p-ERK was significantly decreased in ABA-injected animals, which were not observed in the ABA+H.89-treated group. Conclusions: Overall, i.t. administration of ABA (10 µg/rat) induced analgesia and p-ERK down-expression likely by involving the PKA-dependent mechanism.
DOI: 10.6084/m9.figshare.11804286.v1
title: Association between cognitive impairment and criteria for frailty syndrome among older adults

description: Abstract The association between cognitive impairment and physical frailty has been studied in older adults. The criteria degree of frailty may be keys to associated cognitive impairment. Objective: To analyze the association between cognitive impairment and the criteria for frailty. Methods: We cross-sectionally examined data from 667 older adults (≥60 years of age) from a study entitled ‘Variables associated to cognition in elderly caregivers’ involving patients in an urban and rural primary healthcare center. We defined cognitive impairment based on different groups of scores on the Mini Mental State Examination, and defined frailty and prefrailty using the criteria by the Cardiovascular Health Study. We performed multinomial regression models to analyze the association between levels of frailty and cognitive impairment. Results: Similar proportions of women (54.8%) and men (45.2%) participated in the study (mean age: 71 years old). We found cognitive impairment, prefrailty and frailty in 34, 54, and 24% of the participants, respectively. Concomitant cognitive impairment and frailty was found in 13% of them. The chances of cognitive impairment increased up to 330% (Odds Ratio [OR]: 4.3; 95% confidence interval [95%CI] 2.4‒7.7; p&lt;0.001) among frail individuals, and 70% (OR: 1.7; 95%CI 1.0‒2.8; p=0.033) among prefrail individuals compared to robust/non-frail individuals. After controlling for age, education, place of residence and functional dependence, slowness and fatigue criteria were significantly associated with cognitive impairment. Conclusion: Older adults with frailty have a greater likelihood of concomitant cognitive impairment than prefrail and robust older adults. The prevalence of cognitive impairment and frailty is consistent with data reported in literature. The present findings contribute to the investigation of cognitive frailty.
DOI: 10.6084/m9.figshare.11804274
title: Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate

description: Abstract Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.
DOI: 10.6084/m9.figshare.11804277
title: Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease

description: Abstract Alzheimer’s disease (AD) is the most common cause of dementia. Despite numerous studies on the subject, the pathologies for AD are still unclear and there is still no ideal biomarker for diagnosis. The present study aimed to investigate clinical significance of human complement factor H (CFH) in patients with late-onset AD. Methods: The present prospective study included 187 late-onset AD patients who went to our hospital from January 2015 to December 2017. One hundred patients with mild cognitive impairment (MCI) and 80 healthy individuals who were age and gender matched to AD patients were enrolled as controls. Demographic data such as age, gender, and education duration were recorded. Blood samples were collected and serum levels of C-reactive protein (CRP), CFH, and brain-derived neurotrophic factor (BDNF) were determined by Enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) score was measured for all patients. Results: No significant difference was found in age, gender, and education duration for all participants. The MMSE scores showed AD patients had lower MMES scores than the other two groups. All factors of CFH, CRP, and BDNF were dramatically decreased in AD patients compared with the MCI and the ealthy control. Levels of CFH were found to be positively correlated with levels of CRP; however, no significant correlation was found between CFH and BDNF, nor CFH and MMSE. Conclusion: CFH was decreased in late-onset AD patients, and serum levels of CFH was correlated with serum levels of CRP, but not MMSE and BDNF. These results may provide more clinical evidences for the role of CFH in AD patients.
DOI: 10.6084/m9.figshare.11804277.v1
title: Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease

description: Abstract Alzheimer’s disease (AD) is the most common cause of dementia. Despite numerous studies on the subject, the pathologies for AD are still unclear and there is still no ideal biomarker for diagnosis. The present study aimed to investigate clinical significance of human complement factor H (CFH) in patients with late-onset AD. Methods: The present prospective study included 187 late-onset AD patients who went to our hospital from January 2015 to December 2017. One hundred patients with mild cognitive impairment (MCI) and 80 healthy individuals who were age and gender matched to AD patients were enrolled as controls. Demographic data such as age, gender, and education duration were recorded. Blood samples were collected and serum levels of C-reactive protein (CRP), CFH, and brain-derived neurotrophic factor (BDNF) were determined by Enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) score was measured for all patients. Results: No significant difference was found in age, gender, and education duration for all participants. The MMSE scores showed AD patients had lower MMES scores than the other two groups. All factors of CFH, CRP, and BDNF were dramatically decreased in AD patients compared with the MCI and the ealthy control. Levels of CFH were found to be positively correlated with levels of CRP; however, no significant correlation was found between CFH and BDNF, nor CFH and MMSE. Conclusion: CFH was decreased in late-onset AD patients, and serum levels of CFH was correlated with serum levels of CRP, but not MMSE and BDNF. These results may provide more clinical evidences for the role of CFH in AD patients.
DOI: 10.6084/m9.figshare.11804280
title: Ondine’s curse: the origin of the myth

description: ABSTRACT Central alveolar hypoventilation syndrome has been known for decades as Ondine’s curse. It was named as such after a German myth. Although most of the stories resemble one another, word of mouth has led to misinterpretation of this tale among the medical community. The present paper reviews the original narrative, its characters, and how it is linked to the most relevant aspects of the disease.
DOI: 10.6084/m9.figshare.11804274.v1
title: Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate

description: Abstract Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.
DOI: 10.6084/m9.figshare.11804268
title: Elaboration, evaluation of nutritional information and physical-chemical stability of dairy fermented drink with caja-mango pulp

description: ABSTRACT: Whey is a by-product of the dairy industry of great importance due to its high nutritional value, and can be used for the manufacture of fermented dairy drinks which, combined with fruit, increase the nutritional value and add characteristic flavors. Therefore, a fermented dairy beverage with caja-mango pulp (Spondias dulcis) was elaborated and its nutritional information as well as the physical-chemical stability were evaluated during storage. The results showed that the nutritional information met the requirements stipulated by the Brazilian legislation. The physical-chemical stability of the dairy fermented drink in terms of pH, acidity, syneresis and sedimentation was influenced by the storage time, possibly associated with uncontrolled factors in this study, such as the initial and final dairy culture concentration of the processed product, protein biodegradation during storage and low solids contents. It is concluded that the elaborated drink constitutes a food source of several nutrients, and may complement the daily diet of children, adolescents and adults, supplying nutritional deficiencies.
DOI: 10.6084/m9.figshare.11804265
title: Presence of anti-Leptospira spp. antibodies in captive yellow-spotted river turtles (Podocnemis unifilis) in the Eastern Amazon

description: ABSTRACT: We describe anti-Leptospira spp. agglutinin in yellow-spotted river turtles (Podocnemis unifilis)in the Amazon region. Ninety-eight serum samples from individuals housed at the Bosque Rodrigues Alves Zoobotanical Garden of Amazonia, Belém, PA, Brazil, were subject to the microscopic agglutination test (MAT) using 19 different Leptospira spp. antigen serogroups. Thirty-four of the 98 samples (35%) were reactive, with titers ranging from 100 to 3200, and eight 8 reactive samples (23.5%) co-agglutinated under two or more serovars.The most common serogroup was Hebdomadis (26.9%, 7/26), followed by Semaranga (23%, 6/26), Shermani (19.2%, 5/26), Djasiman (11.5%, 3/26), and Australis (7.7%, 2/26); Bataviae, Javanica, and Sejroewere represented by a single sample each (3.9%). The presence of turtles reactive to anti-Leptospira spp. antibodies implies exposure to the pathogen.
DOI: 10.6084/m9.figshare.11804265.v1
title: Presence of anti-Leptospira spp. antibodies in captive yellow-spotted river turtles (Podocnemis unifilis) in the Eastern Amazon

description: ABSTRACT: We describe anti-Leptospira spp. agglutinin in yellow-spotted river turtles (Podocnemis unifilis)in the Amazon region. Ninety-eight serum samples from individuals housed at the Bosque Rodrigues Alves Zoobotanical Garden of Amazonia, Belém, PA, Brazil, were subject to the microscopic agglutination test (MAT) using 19 different Leptospira spp. antigen serogroups. Thirty-four of the 98 samples (35%) were reactive, with titers ranging from 100 to 3200, and eight 8 reactive samples (23.5%) co-agglutinated under two or more serovars.The most common serogroup was Hebdomadis (26.9%, 7/26), followed by Semaranga (23%, 6/26), Shermani (19.2%, 5/26), Djasiman (11.5%, 3/26), and Australis (7.7%, 2/26); Bataviae, Javanica, and Sejroewere represented by a single sample each (3.9%). The presence of turtles reactive to anti-Leptospira spp. antibodies implies exposure to the pathogen.
DOI: 10.6084/m9.figshare.11804268.v1
title: Elaboration, evaluation of nutritional information and physical-chemical stability of dairy fermented drink with caja-mango pulp

description: ABSTRACT: Whey is a by-product of the dairy industry of great importance due to its high nutritional value, and can be used for the manufacture of fermented dairy drinks which, combined with fruit, increase the nutritional value and add characteristic flavors. Therefore, a fermented dairy beverage with caja-mango pulp (Spondias dulcis) was elaborated and its nutritional information as well as the physical-chemical stability were evaluated during storage. The results showed that the nutritional information met the requirements stipulated by the Brazilian legislation. The physical-chemical stability of the dairy fermented drink in terms of pH, acidity, syneresis and sedimentation was influenced by the storage time, possibly associated with uncontrolled factors in this study, such as the initial and final dairy culture concentration of the processed product, protein biodegradation during storage and low solids contents. It is concluded that the elaborated drink constitutes a food source of several nutrients, and may complement the daily diet of children, adolescents and adults, supplying nutritional deficiencies.
DOI: 10.6084/m9.figshare.11804187
title: Stability of snacks made with minced Nile tilapia stored at room temperature

description: ABSTRACT Minced fish can be used in the preparation of fish products, despite being very susceptible to lipid oxidation and microbial growth. Fish snacks are widely appreciated in Asian countries, but still little studied in Brazil. Thus, the aim of this study was to produce snacks containing 20, 30, and 40% minced fish of Nile tilapia filleting waste and evaluate their stability at time zero and throughout 15, 30, and 45 days of storage at room temperature (25 ºC) by physicochemical, microbiological, and sensory characterization. The inclusion of minced fish decreased (P &lt;0.05) the volatile nitrogenous base levels (0.71 to 0.56 mg N.100g-1) and increased pH (5.45 to 5.90) of the snacks. An increase (P &lt;0.05) in lipid oxidation (1.10 to 2.03 mg. malonaldehyde. kg-1) and pH (5.57 to 5.73) was observed during storage. Lower microbial counts were observed, which were within the limit allowed by the Brazilian legislation. Sensory acceptance of the attributes flavor, color, texture, global acceptance, and purchase intent of the snacks decreased with increasing the inclusion of minced fish, but remained with scores above 5, which is equivalent to “not liked nor disliked”. During 45 days of storage, the sensory properties of the snacks remained stable with good acceptance scores. Therefore, fish snacks can be made with the addition of 20 to 40% of minced fish of Nile tilapia filleting waste without compromising their sensory acceptance and physicochemical and microbiological stability during 45 days of storage at 25 ºC.
DOI: 10.6084/m9.figshare.11804187.v1
title: Stability of snacks made with minced Nile tilapia stored at room temperature

description: ABSTRACT Minced fish can be used in the preparation of fish products, despite being very susceptible to lipid oxidation and microbial growth. Fish snacks are widely appreciated in Asian countries, but still little studied in Brazil. Thus, the aim of this study was to produce snacks containing 20, 30, and 40% minced fish of Nile tilapia filleting waste and evaluate their stability at time zero and throughout 15, 30, and 45 days of storage at room temperature (25 ºC) by physicochemical, microbiological, and sensory characterization. The inclusion of minced fish decreased (P &lt;0.05) the volatile nitrogenous base levels (0.71 to 0.56 mg N.100g-1) and increased pH (5.45 to 5.90) of the snacks. An increase (P &lt;0.05) in lipid oxidation (1.10 to 2.03 mg. malonaldehyde. kg-1) and pH (5.57 to 5.73) was observed during storage. Lower microbial counts were observed, which were within the limit allowed by the Brazilian legislation. Sensory acceptance of the attributes flavor, color, texture, global acceptance, and purchase intent of the snacks decreased with increasing the inclusion of minced fish, but remained with scores above 5, which is equivalent to “not liked nor disliked”. During 45 days of storage, the sensory properties of the snacks remained stable with good acceptance scores. Therefore, fish snacks can be made with the addition of 20 to 40% of minced fish of Nile tilapia filleting waste without compromising their sensory acceptance and physicochemical and microbiological stability during 45 days of storage at 25 ºC.
DOI: 10.6084/m9.figshare.11804184
title: Adaptation and application of the erosion potential method for tropical soils1

description: ABSTRACT The water erosion process has a considerable negative effect on tropical soils, causes soil losses from arable land and reduces the capacity to support surrounding ecosystems. Estimating soil losses caused by water erosion is fundamental for evaluating the impacts of various production systems. Therefore, improving soil loss estimates via the adaptation of models for different edaphoclimatic environments is necessary for estimating local geographic and climatic differences. This study aimed to adapt, apply and evaluate the potentialities of the Potential Erosion Method for Latosols of the Hydrographic Subbasin of Caçús Stream, southern Minas Gerais State. Geological, topographic, pedological, climatic and land use and occupation data were processed via Geographic Information Systems and compared with those obtained by the Revised Universal Soil Loss Equation. The erosion intensity coefficient, Z, was 0.28, indicating weak erosion intensity, and the estimated average soil losses were 31 Mg ha-1 year-1 by the Potential Erosion Method and 36 Mg ha-1 year-1 by the Revised Universal Soil Loss Equation, which were both above the soil loss tolerance. The model results and comparisons indicated that the Potential Erosion Method has excellent performance and can be applied to estimate sediment production via water erosion in tropical soils.
DOI: 10.6084/m9.figshare.11804184.v1
title: Adaptation and application of the erosion potential method for tropical soils1

description: ABSTRACT The water erosion process has a considerable negative effect on tropical soils, causes soil losses from arable land and reduces the capacity to support surrounding ecosystems. Estimating soil losses caused by water erosion is fundamental for evaluating the impacts of various production systems. Therefore, improving soil loss estimates via the adaptation of models for different edaphoclimatic environments is necessary for estimating local geographic and climatic differences. This study aimed to adapt, apply and evaluate the potentialities of the Potential Erosion Method for Latosols of the Hydrographic Subbasin of Caçús Stream, southern Minas Gerais State. Geological, topographic, pedological, climatic and land use and occupation data were processed via Geographic Information Systems and compared with those obtained by the Revised Universal Soil Loss Equation. The erosion intensity coefficient, Z, was 0.28, indicating weak erosion intensity, and the estimated average soil losses were 31 Mg ha-1 year-1 by the Potential Erosion Method and 36 Mg ha-1 year-1 by the Revised Universal Soil Loss Equation, which were both above the soil loss tolerance. The model results and comparisons indicated that the Potential Erosion Method has excellent performance and can be applied to estimate sediment production via water erosion in tropical soils.
DOI: 10.6084/m9.figshare.11804175
title: Corn supplementation on milk urea nitrogen content of dairy cows grazing on temperate annual pasture

description: ABSTRACT: The excretion of urinary nitrogen (N), one of the most important environmental contaminants from livestock systems, is highly correlated with milk urea N content. The objective of this research was to evaluate the use of different types of corn supplementation on milk urea N in grazing dairy cows. Twelve Holstein × Jersey lactating dairy cows were divided into six uniform groups according to milk production, lactation stage and live weight. Treatments were compared according to a 3 × 3 replicated Latin square experimental design, with three periods of seventeen days (twelve days to adaptation and five to measurements). The experimental treatments were exclusively grazing (G); grazing + supplementation with 4.2 kg DM of corn silage (CS) and grazing + supplementation with 3.2 kg DM of ground corn (GC). The pasture used was annual ryegrass (Lolium multiflorum L.) and white oats (Avena sativa L.). The milk protein production increased 65 g/day in the GC treatment group compared to the G and CS groups. The supplemented dairy cows showed lower milk urea N (-2.8 mg/dL) than unsupplemented cows, but the N utilization efficiency (g N output in milk/ g N intake) did not change between treatments (average = 0.26). Additionally, there was a relationship between milk and plasma urea nitrogen concentrations (R2 = 0.64). In conclusion, for dairy cows grazing annual temperate pastures, corn ground supplementation increased milk protein production and reduced the excretion of milk urea N, whereas corn silage reduced the excretion of milk urea N without affecting milk protein production.