cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6085/aa/bckx00_xxxix01xmsr01_20220622.50.2
title: MARINe/PISCO: Intertidal: site temperature data: Bob Creek, Oregon (BCKX00)

description: This metadata record describes a mix of intertidal seawater and air temperature data collected at Bob Creek, Oregon by MARINe/PISCO. Measurements were collected using HOBO Pendant MX Water Temperature Data Logger (Onset Computer Corp. MX2201) beginning 2022-06-30. Site temperature loggers are bolted down in a wire cage at various locations within each site. Mussel growth temperature loggers are bolted down in a wire cage at high, mid, or low positions within a mussel bed. Temperature is recorded at 10 or 15 minute intervals.
DOI: 10.18112/openneuro.ds004357.v1.0.1
title: Features-EEG
DOI: 10.6084/m9.figshare.24970794
title: Available data

description: Major and trace elemets of olivine melt inclusions
DOI: 10.5281/zenodo.10476992
title: Dataset for 'Switches between nitrogen limitation and nitrogen–phosphorus co-limitation in the subtropical North Atlantic Ocean' by Yuan et al. 2024. Limnology and Oceanography

description: Dataset for 'Switches between nitrogen limitation and nitrogen–phosphorus co-limitation in the subtropical North Atlantic Ocean' by Yuan et al. 2024. Limnology and Oceanography.
DOI: 10.5281/zenodo.10476993
title: Dataset for 'Switches between nitrogen limitation and nitrogen–phosphorus co-limitation in the subtropical North Atlantic Ocean' by Yuan et al. 2024. Limnology and Oceanography

description: Dataset for 'Switches between nitrogen limitation and nitrogen–phosphorus co-limitation in the subtropical North Atlantic Ocean' by Yuan et al. 2024. Limnology and Oceanography.
DOI: 10.6084/m9.figshare.24966375
title: Result of pre-test and post-test using Indonesian adaptation self-assessment generic skills tool in English and Indonesian Language

description: Result of pre-test and post-test using Indonesian adaptation self-assessment generic skills tool in English and Indonesian Language
DOI: 10.6084/m9.figshare.24966375.v1
title: Result of pre-test and post-test using Indonesian adaptation self-assessment generic skills tool in English and Indonesian Language

description: Result of pre-test and post-test using Indonesian adaptation self-assessment generic skills tool in English and Indonesian Language
DOI: 10.25946/22779323
title: 2018-ferguson-afs-couldry-meets-bourdieu

description: 84 front page images print edition Daily Mail
84 front page images print edition The Guardian
1 front page print edition Daily Express
168 front page headlines 
Excel spreadsheet data/data analysis/data manipulation
DOI: 10.25946/22779323.v1
title: 2018-ferguson-afs-couldry-meets-bourdieu

description: 84 front page images print edition Daily Mail
84 front page images print edition The Guardian
1 front page print edition Daily Express
168 front page headlines 
Excel spreadsheet data/data analysis/data manipulation
DOI: 10.25952/gh62-w110
title: Generational Attributes of Educational Leadership

description: Educational leadership was investigated from three generational perspectives within a Mid North Coast (MNC) school context. A collective case study enabled comparative exploration of Baby Boomers, Generation X and Generation Y (2 females and 2 males from each generation). Participant selection was based on age, gender and either aspirational or established leaders. Investigation of generation attributes towards leadership was conducted through twelve interviews. Interview data were recorded, transcribed and analysed using both manual coding and Leximancer text mining software. Findings contributed to the idea of generational collide and the concepts of self and identity, knowledge and skills and professional learning emerged as interconnected.  Implications informed a new leadership framework to guide MNC educational leaders and systemic reforms for professional learning.
description: Educational leadership was investigated from three generational perspectives within a Mid North Coast (MNC) school context. A collective case study enabled comparative exploration of Baby Boomers, Generation X and Generation Y (2 females and 2 males from each generation). Participant selection was based on age, gender and either aspirational or established leaders. Investigation of generation attributes towards leadership was conducted through twelve interviews. Interview data were recorded, transcribed and analysed using both manual coding and Leximancer text mining software. Findings contributed to the idea of generational collide and the concepts of self and identity, knowledge and skills and professional learning emerged as interconnected.  Implications informed a new leadership framework to guide MNC educational leaders and systemic reforms for professional learning.
DOI: 10.6084/m9.figshare.24970515
title: 原始数据

description: The mechanisms of Ping-Gan-Yi-Shen Granules ameliorate hypertension inspontaneously hypertensive rat
DOI: 10.6084/m9.figshare.24970515.v1
title: 原始数据

description: The mechanisms of Ping-Gan-Yi-Shen Granules ameliorate hypertension inspontaneously hypertensive rat
DOI: 10.21947/2279150
title: Gulf of Mexico Turbulence Intensity Model Data

description: The dataset is a subset of simulations carried out for the Gulf of Mexico region using the revised Weather Research and Forecasting (WRF) model version 4.2 that incorporates the implementation of online turbulence intensity (TI) calculations (Tai et al. 2023). The simulated atmospheric profiles near the Shell Exploration and Production Corporation's Tension Leg Platforms Ursa and Mars are archived. Physics parameterizations chosen for the simulations include the Thompson microphysics parameterization, Mellor-Yamada-Nakanishi Niino (MYNN) boundary layer parameterization, Mellor-Yamada-Janjic surface layer parameterization, Unified Noah land-surface parameterization, and the RRTMG longwave and shortwave radiation parameterization. Initial and boundary conditions are taken from the NOAA’s High-Resolution Rapid Refresh (HRRR) product. The JPL 0.01-degree Level 4 Multiscale Ultrahigh Resolution (MUR) Global Foundation Sea Surface Temperature (SST) Analysis (V4.1) data are used as the model’s SST forcing. Simulations are performed from January through June in 2020 and output every 10 minutes, which permits comparison with corresponding lidar observations.
DOI: 10.5281/zenodo.10445642
title: Interplanetary magnetic field By controlled Alfven wings at Earth during encounter of a coronal mass ejection

description: This data set contains input and output of the global MHD simulation in the article "Interplanetary magnetic field By controlled Alfven wings at Earth during encounter of a coronal mass ejection". 

1. Simulation input files:   a) IMF.dat: solar wind conditions for the simulation   b) PARAM.in.ss and PARAM.in.ta: input files for the steady state (.ss) and time accurate (.ta) stages

2. Simulation output:   a) sim.csv: simulation output along the virtual satellite trajectory, which is used for figure2.   b) 3d__var_4_t00220000_n02275984_vtk.zip: 3D output that is used for figure3-7. After decompression, it is a vtu file and can be opened with Paraview.
DOI: 10.5281/zenodo.10477061
title: WIDER RECOMMENDATION OF NATURAL MEDICINAL LEMON TO THE PUBLIC.
DOI: 10.5281/zenodo.10477062
title: WIDER RECOMMENDATION OF NATURAL MEDICINAL LEMON TO THE PUBLIC.
DOI: 10.5281/zenodo.10477064
title: АБДУЛЛА КАДИРИ И КАРЛУКСКИЕ ДИАЛЕКТЫ (НА ПРИМЕРЕ УЗБЕКСКИХ ДИАЛЕКТОВ САМАРКАНДСКОЙ ОБЛАСТИ)
DOI: 10.5281/zenodo.10477065
title: АБДУЛЛА КАДИРИ И КАРЛУКСКИЕ ДИАЛЕКТЫ (НА ПРИМЕРЕ УЗБЕКСКИХ ДИАЛЕКТОВ САМАРКАНДСКОЙ ОБЛАСТИ)
DOI: 10.5281/zenodo.10477074
title: NEW VIEWS ON ETIOLOGY AND PATOGENESIS OF AVASCULAR  NECROSIS OF  FEMORAL HEAD  IN PATIENTS WITH COVID 19
DOI: 10.5281/zenodo.10477075
title: NEW VIEWS ON ETIOLOGY AND PATOGENESIS OF AVASCULAR  NECROSIS OF  FEMORAL HEAD  IN PATIENTS WITH COVID 19
DOI: 10.6084/m9.figshare.24971337.v1
title: Additional file 1 of Community-acquired Staphylococcus aureus skin and soft tissue infection risk assessment using hotspot analysis and risk maps: the case of California emergency departments

description: Additional file 1: Table A1. List of California Medical Service Study Areas (MSSA) that have high-high rates of CA-MRSA clustering (HH), low-low rates of CA-MRSA clustering (LL), and low-high rates of CA-MRSA clustering (LH), 2016-2019. Table A2. Ten California MSSAs with the highest and lowest risk ratio for CA-MRSA between 2016-2019. A3. Analysis code - R-Markdown html file.
DOI: 10.6084/m9.figshare.24971337
title: Additional file 1 of Community-acquired Staphylococcus aureus skin and soft tissue infection risk assessment using hotspot analysis and risk maps: the case of California emergency departments

description: Additional file 1: Table A1. List of California Medical Service Study Areas (MSSA) that have high-high rates of CA-MRSA clustering (HH), low-low rates of CA-MRSA clustering (LL), and low-high rates of CA-MRSA clustering (LH), 2016-2019. Table A2. Ten California MSSAs with the highest and lowest risk ratio for CA-MRSA between 2016-2019. A3. Analysis code - R-Markdown html file.
DOI: 10.6084/m9.figshare.24971345.v1
title: Additional file 1 of Prevalence of food insecurity amid COVID-19 lockdowns and sociodemographic indicators of household vulnerability in Harar and Kersa, Ethiopia

description: Additional file 1: Supplementary Methods. Wealth Index Generation. Supplementary Methods. Survey Instrument.
DOI: 10.6084/m9.figshare.24971345
title: Additional file 1 of Prevalence of food insecurity amid COVID-19 lockdowns and sociodemographic indicators of household vulnerability in Harar and Kersa, Ethiopia

description: Additional file 1: Supplementary Methods. Wealth Index Generation. Supplementary Methods. Survey Instrument.
DOI: 10.6084/m9.figshare.24971382.v1
title: Additional file 1 of An overlooked phenomenon: complex interactions of potential error sources on the quality of bacterial de novo genome assemblies

description: Additional file 1.
DOI: 10.6084/m9.figshare.24971382
title: Additional file 1 of An overlooked phenomenon: complex interactions of potential error sources on the quality of bacterial de novo genome assemblies

description: Additional file 1.
DOI: 10.5281/zenodo.10477081
title: WASTE IS A VALUABLE RAW MATERIAL
DOI: 10.5281/zenodo.10477082
title: WASTE IS A VALUABLE RAW MATERIAL
DOI: 10.5281/zenodo.10477031
title: Data for: Diversity of Functional Edaphic Macrofauna in Musa acuminata x Musa balbisiana (AAB) Agroecosystems

description: The Dataset is linked to the article  Diversity of Functional Edaphic Macrofauna in Musa acuminata x Musa balbisiana (AAB) Agroecosystems.   The collected individuals were analyzed by order, and family and quantified and identified by gender (Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC: PMC7408187.), The collection and taxonomic identification phase is explained in the protocol.i (dx.doi.org/10.17504/protocols.io.rm7vzby75vx1/v1).

This dataset was a modification as was indicated for the #GlobalSoilMacroFauna | Official template to report Data to the MACROFAUNA database (#GlobalSoilMacroFauna | Official template to report Data to the MACROFAUNA database (zenodo.org)) cited by [Mathieu, J., Antunes, A. C., Barot, S., Bonato Asato, A. E. ., Bartz, M. L. C. ., Brown, G. G., Calderon-Sanou, I., Decaëns, T., Fonte, S. J., Ganault, P., Gauzens, B., Gongalsky, K. B., Guerra, C. A., Hengl, T., Lavelle, P., Marichal, R., Mehring, H., Peña-Venegas, C. P., Castro, D., Potapov, A., Thébault, E., Thuiller, W., Witjes, M., Zhang, C., & Eisenhauer, N. (2022). sOilFauna - a global synthesis effort on the drivers of soil macrofauna communities and functioning: WORKSHOP REPORT . SOIL ORGANISMS, 94(2), 111–126. https://doi.org/10.25674/so94iss2id282]
DOI: 10.5281/zenodo.7242969
title: Data for: Diversity of Functional Edaphic Macrofauna in Musa acuminata x Musa balbisiana (AAB) Agroecosystems

description: Dataset is linked to the article in progress <strong>Diversity of Functional Edaphic Macrofauna in <em>Musa acuminata x Musa balbisiana</em> (AAB) Agroecosystems.</strong> The collected individuals were analyzed by order, and family and quantified and identified by gender (Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC: PMC7408187.), The collection and taxonomic identification phase is explained in the protocol.i (dx.doi.org/10.17504/protocols.io.rm7vzby75vx1/v1).
description: {"references": ["Schoch CL, et al. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC", "Kim, Yongkyu, and Werner Liesack. \"DAFGA: diversity analysis of functional gene amplicons.\" Bioinformatics 30, no. 19 (2014): 2820-2821.", "Z\u00faniga-Gonzalez CA and Caballero-Hern\u00e1ndez AJ. Diversity of functional edaphic macrofauna in Musa acuminata x Musa balbisiana (AAB) agroecosystems [version 1; peer review: awaiting peer review]. F1000Research 2022, 11:1300 (https://doi.org/10.12688/f1000research.127300.1)"]}
DOI: 10.5281/zenodo.7255724
title: Data for: Diversity of Functional Edaphic Macrofauna in Musa acuminata x Musa balbisiana (AAB) Agroecosystems

description: Dataset is linked to the article <strong>Diversity of Functional Edaphic Macrofauna in <em>Musa acuminata x Musa balbisiana</em> (AAB) Agroecosystems.</strong> The collected individuals were analyzed by order, and family and quantified and identified by gender (Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC: PMC7408187.), The collection and taxonomic identification phase is explained in the protocol.i (dx.doi.org/10.17504/protocols.io.rm7vzby75vx1/v1).
description: {"references": ["Schoch CL, et al. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC", "Kim, Yongkyu, and Werner Liesack. \"DAFGA: diversity analysis of functional gene amplicons.\" Bioinformatics 30, no. 19 (2014): 2820-2821."]}
DOI: 10.5281/zenodo.10477084
title: MAKING ANHYDROUS CEMENT AND LIME PHOSPHORUS BINDER FROM PHOSPHORGYPSUM
DOI: 10.5281/zenodo.10477085
title: MAKING ANHYDROUS CEMENT AND LIME PHOSPHORUS BINDER FROM PHOSPHORGYPSUM
DOI: 10.5281/zenodo.10477087
title: ELEKTROTERMIK FOSFOR OLISH TEXNOLOGIYASI
DOI: 10.5281/zenodo.10477088
title: ELEKTROTERMIK FOSFOR OLISH TEXNOLOGIYASI
DOI: 10.6084/m9.figshare.24971649
title: CHB for stepwise M2BPGi

description: This is the raw data from CHB patients who underwent blood profile tests, including M2BPGi. All data were from the Hasan Sadikin Chronic Hepatitis B Registry.
DOI: 10.5281/zenodo.10477091
title: GIPS YOKI FOSFOGIPS TOSHQOLLARNING BOG'LOVCHILIK XUSUSIYATLARINI QO'ZG'ATUVCHI QO'SHILMA SIFATIDA.
DOI: 10.5281/zenodo.10477092
title: GIPS YOKI FOSFOGIPS TOSHQOLLARNING BOG'LOVCHILIK XUSUSIYATLARINI QO'ZG'ATUVCHI QO'SHILMA SIFATIDA.
DOI: 10.5281/zenodo.10477097
title: THE USE OF INTERTEXTUALITY IN LANGUAGE
DOI: 10.5281/zenodo.10477096
title: THE USE OF INTERTEXTUALITY IN LANGUAGE
DOI: 10.5281/zenodo.10475649
title: 01_ALI_CRL_and_MCL_α-diversity_analysis_R_code

description: Water and sediment samples were collected from Chang-re Lake (CRL) and Mang co Lake (MCL), the northwestern Tibetan Plateau. Using multi-marker metabarcoding of eDNA derived from water at multiple depths and from sediments, we analyzed the community composition of four taxonomic groups representative of different trophic levels, including cyanobacteria (prokaryotic primary producers), diatoms (eukaryotic primary producers), invertebrates (lower-level consumers), and vertebrates (top consumers). Here are the R scripts used in this study.
DOI: 10.5281/zenodo.10477102
title: SCIENTIFIC INTERPRETATION OF SOIL WATER PERMEABILITY PROPERTIES
DOI: 10.5281/zenodo.10477103
title: SCIENTIFIC INTERPRETATION OF SOIL WATER PERMEABILITY PROPERTIES
DOI: 10.5281/zenodo.10477108
title: THE ANGREN-POP RAILWAY AS A MAJOR FACTOR IN INCREASING ECONOMIC GROWTH AND COMMODITY DIVERSIFICATION IN UZBEKISTAN'S POST-INDEPENDENCE YEARS
DOI: 10.5281/zenodo.10477107
title: THE ANGREN-POP RAILWAY AS A MAJOR FACTOR IN INCREASING ECONOMIC GROWTH AND COMMODITY DIVERSIFICATION IN UZBEKISTAN'S POST-INDEPENDENCE YEARS
DOI: 10.6084/m9.figshare.24971169.v1
title: <b>Ferroptosis</b><b>-Related Genes Risk Model Associated with </b><b>Disulfidptosis</b><b> in Hepatocellular Carcinoma Prognosis</b>

description: <b>Ferroptosis</b><b>-Related Genes Risk Model Associated with </b><b>Disulfidptosis</b><b> in Hepatocellular Carcinoma Prognosis</b>
DOI: 10.6084/m9.figshare.24971169
title: <b>Ferroptosis</b><b>-Related Genes Risk Model Associated with </b><b>Disulfidptosis</b><b> in Hepatocellular Carcinoma Prognosis</b>

description: <b>Ferroptosis</b><b>-Related Genes Risk Model Associated with </b><b>Disulfidptosis</b><b> in Hepatocellular Carcinoma Prognosis</b>
DOI: 10.5281/zenodo.10477109
title: FANLARARO INTEGRATSIYA ASOSIDA  LOYIHALASH METODI VA UNI TAKOMILLASHTIRISH USLUBIYOTI
DOI: 10.5281/zenodo.10477110
title: FANLARARO INTEGRATSIYA ASOSIDA  LOYIHALASH METODI VA UNI TAKOMILLASHTIRISH USLUBIYOTI
DOI: 10.5281/zenodo.10477112
title: THE DIRECT TEACHING METHOD
DOI: 10.5281/zenodo.10477111
title: THE DIRECT TEACHING METHOD
DOI: 10.5281/zenodo.10477114
title: LINGUOCULTUROLOGICAL ASPECTS OF ENGLISH PHRASEOLOGY: UNDERSTANDING THE INTERSECTION OF LANGUAGE AND CULTURE
DOI: 10.5281/zenodo.10477115
title: LINGUOCULTUROLOGICAL ASPECTS OF ENGLISH PHRASEOLOGY: UNDERSTANDING THE INTERSECTION OF LANGUAGE AND CULTURE
DOI: 10.6084/m9.figshare.24471919
title: Data for Spatiotemporal co-optimization of agricultural management practices

description: Spatiotemporal co-optimization of agricultural management practices towards climate-smart crop production.
DOI: 10.5281/zenodo.10476969
title: Data for "Mechanically-Sensitive Fluorochromism by Molecular Domino Transformation in a Schiff Base Crystal"

description: The dataset contains input and output files of computational chemistry by Quantum ESPRESSO and Gaussian softwares conducted on two polymorphic crystal structures of 4-nitro-N-salicylideneaniline.
DOI: 10.5281/zenodo.8260130
title: Data for "Mechanically-Sensitive Fluorochromism by Molecular Domino Transformation in a Schiff Base Crystal"

description: The dataset contains input and output files of computational chemistry by Quantum ESPRESSO and Gaussian softwares conducted on two polymorphic crystal structures of 4-nitro-N-salicylideneaniline.
DOI: 10.5281/zenodo.8260131
title: Data for "Mechanically-Sensitive Fluorochromism by Molecular Domino Transformation in a Schiff Base Crystal"

description: This dataset contains input and output files of computational chemistry by CONFLEX conducted on two polymorphic crystal structures of 4-nitro-N-salicylideneaniline.
DOI: 10.6084/m9.figshare.24971781
title: Supplementary Material for: The prenatal hypoxic pathology associated with maternal stress predisposes to dysregulated expression of the chrna7 gene and the subsequent development of nicotine addiction in adult offspring

description: Introduction: Previous studies have shown that fetal hypoxia predisposes individuals to develop addictive disorders in adulthood. However, the specific impact of maternal stress, mediated through glucocorticoids and often coexisting with fetal hypoxia, is not yet fully comprehended. Methods: To delineate the potential effects of these pathological factors, we designed models of prenatal severe hypoxia (PSH) in conjunction with maternal stress and prenatal intrauterine ischemia (PII). We assessed the suitability of these models for our research objectives by measuring HIF1α levels and evaluating the glucocorticoid neuroendocrine system. To ascertain nicotine dependence, we employed the conditioned place aversion test and the startle response test. To identify the key factor implicated in nicotine addiction associated with PSH, we employed techniques such as western blot, immunohistochemistry, and correlational analysis between chrna7 and nr3c1 genes across different brain structures. Results: In adult rats exposed to PSH and PII, we observed increased levels of HIF1α in the hippocampus (HPC). However, the PSH group alone exhibited reduced glucocorticoid receptor (GR) levels and disturbed circadian glucocorticoid rhythms. Additionally, they displayed signs of nicotine addiction in the conditioned place aversion and startle response tests. We also observed elevated levels of phosphorylated DARPP-32 protein in the nucleus accumbens (NAc) indicated compromised glutamatergic efferent signaling. Furthermore, there was reduced expression of α7 nAChR, which modulates glutamate release, in the medial prefrontal cortex (PFC) and HPC. Correlation analysis revealed strong associations between chrna7 and nr3c1 expression in both brain structures.
Conclusion: Perturbations in the glucocorticoid neuroendocrine system and glucocorticoid-dependent gene expression of chrna7 associated with maternal stress response to hypoxia in prenatal period favor the development of nicotine addiction in adulthood.
DOI: 10.25952/z554-6c77
title: Evaluation of feed quality and supply to the small-to-medium-scale poultry sector in Tanzania - Dataset

description: These are data files related to my thesis titled Evaluation of feed quality and supply to the small-to-medium-scale poultry sector in Tanzania.
description: These are data files related to my thesis titled Evaluation of feed quality and supply to the small-to-medium-scale poultry sector in Tanzania.
DOI: 10.6084/m9.figshare.24971790
title: Supplementary Material for: A Phase 3 Study of Pembrolizumab Versus Placebo for Previously Treated Patients From Asia With Hepatocellular Carcinoma: Health-Related Quality of Life Analysis From KEYNOTE-394

description: Introduction
KEYNOTE-394 showed pembrolizumab significantly improved overall survival, progression-free survival, and objective response rate with manageable safety versus placebo for patients from Asia with previously treated advanced hepatocellular carcinoma. We present results on health-related quality of life (HRQoL).

Methods
HRQoL was evaluated using the EORTC Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and EuroQol-5D-3L (EQ-5D-3L) questionnaires. Key HRQoL endpoints were least squares mean (LSM) score changes from baseline to week 12 and time to deterioration (TTD) for EORTC QLQ-C30 global health status (GHS)/QoL. p values were one-sided and nominal without adjustment for multiplicity.

Results
The HRQoL population included patients randomly assigned to pembrolizumab (n = 298) and placebo (n = 152). From baseline to week 12, a greater decline in EORTC QLQ-C30 GHS/QoL score was observed with placebo (LSM, −8.4; 95% CI: −11.7 to −5.1) versus pembrolizumab (−4.0; 95% CI: −6.4 to −1.6; difference vs placebo: 4.4; 95% CI: 0.5–8.4; nominal p = 0.0142). Similarly, a greater decline in EQ-5D-3L visual analog scale score was observed with placebo (−6.9; 95% CI: −9.4 to −4.5) versus pembrolizumab (−2.7; 95% CI: −4.5 to −1.0; difference vs placebo: 4.2; 95% CI: 1.2–7.2; nominal p = 0.0030). TTD in EORTC QLQ-C30 GHS/QoL score was similar between arms (hazard ratio, 0.85; 95% CI: 0.58–1.25; nominal p = 0.1993).

Conclusion
Patients receiving placebo showed greater decline in HRQoL than those receiving pembrolizumab. Combined with efficacy and safety data from KEYNOTE-394 and the global KEYNOTE-240 and KEYNOTE-224 trials, our data support the clinically meaningful benefit and manageable tolerability of pembrolizumab as second-line therapy for patients with advanced hepatocellular carcinoma.