cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.4hk2039
title: Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis

description: Objective: To investigate safety and explore efficacy of efgartigimod
 (ARGX-113), an anti-neonatal Fc receptor immunoglobulin G1 Fc fragment, in
 patients with generalized myasthenia gravis (gMG) with a history of
 anti-acetylcholine receptor (AChR) autoantibodies, who were on stable
 standard-of-care myasthenia gravis (MG) treatment. Methods: A phase 2,
 exploratory, randomized, double-blind, placebo-controlled, 15-center study
 is described. Eligible patients were randomly assigned (1:1) to receive 4
 doses over a 3-week period of either 10 mg/kg IV efgartigimod or matched
 placebo combined with their standard-of-care therapy. Primary endpoints
 were safety and tolerability. Secondary endpoints included efficacy
 (change from baseline to week 11 of Myasthenia Gravis Activities of Daily
 Living, Quantitative Myasthenia Gravis, and Myasthenia Gravis Composite
 disease severity scores, and of the revised 15-item Myasthenia Gravis
 Quality of Life scale), pharmacokinetics, pharmacodynamics, and
 immunogenicity. Results: Of the 35 screened patients, 24 were enrolled and
 randomized: 12 received efgartigimod and 12 placebo. Efgartigimod was
 well-tolerated in all patients, with no serious or severe adverse events
 reported, no relevant changes in vital signs or ECG findings observed, and
 no difference in adverse events between efgartigimod and placebo
 treatment. All patients treated with efgartigimod showed a rapid decrease
 in total immunoglobulin G (IgG) and anti-AChR autoantibody levels, and
 assessment using all 4 efficacy scales consistently demonstrated that 75%
 showed a rapid and long-lasting disease improvement. Conclusions:
 Efgartigimod was safe and well-tolerated. The correlation between
 reduction of levels of pathogenic IgG autoantibodies and disease
 improvement suggests that reducing pathogenic autoantibodies with
 efgartigimod may offer an innovative approach to treat MG.
description: Supplementary
 Informationsupplementary
 information.pdf
DOI: 10.5061/dryad.gv7827s
title: Data from: Reversing the effects of evolutionary prey naiveté through controlled predator exposure

description: 1. Inappropriate anti-predator responses (naiveté) towards introduced
 predators is a key factor contributing to the extinction and endangerment
 of prey species worldwide and the failure of wildlife reintroductions.
 Here, we test the idea that reintroduction success can be improved by
 exposing a predator naïve prey species to introduced predators under
 controlled conditions (in situ predation) prior to reintroduction, such
 that prey adopt increased wary behaviours to aid in survival. 2. We
 exposed a population of a naïve marsupial, the greater bilby (Macrotis
 lagotis), to a controlled number of introduced predators (feral cats,
 Felis catus) for two years within a large fenced paddock and then compared
 the pre-release behaviour and post-translocation survival of predator
 exposed and predator naïve bilbies over 40 days. 3. Behavioural assays
 conducted in a small pen prior to reintroduction suggested that predator
 exposed bilbies were warier as they spent less time moving and more time
 in cover than predator naïve bilbies. 4. After translocation, predator
 exposed bilbies were more likely to survive to 40 days and were less
 likely to be preyed upon by cats than predator free bilbies. 5. Synthesis
 and applications. Naiveté towards predators is a major problem thwarting
 successful reintroductions worldwide. Our study demonstrates that exposure
 to predators under controlled conditions can increase survival of
 reintroduced prey and is a promising approach to overcome the problem of
 naiveté towards introduced predators and the global problem of prey
 naiveté. Future conservation of naïve prey species may depend on such
 training methods prior to releasing into areas where predators are
 present.
description: Data for Ross et
 alData collected in the
 field at Arid Recovery Reserve in 2017. This data concerns bilby emergence
 time, pen behaviour, burrow use, and survival.
DOI: 10.5061/dryad.8735575
title: Data from: Nitrogen addition reduced ecosystem stability regardless of its impacts on plant diversity

description: 1. Global environmental changes are altering ecosystem stability,
 sometimes by altering biodiversity. For example, by driving grassland
 plant species loss, nitrogen (N) addition can reduce ecosystem stability.
 In other cases, however, N addition may alter productivity and ecosystem
 stability, by increasing the dominance of particularly productive or
 stable species. 2. We examined how N addition affected plant diversity,
 productivity, and the temporal stability of productivity in an 8-year
 grassland experiment. We found that N addition enhanced productivity and
 decreased ecosystem stability throughout the experimental period, even
 though it reduced species richness in the first four years, but increased
 richness during the subsequent years. 3. During the early years, N
 addition decreased ecosystem stability by synchronizing species
 fluctuations and population stability of the dominant species. During
 later years, N addition did not increase stability, even though it
 increased species richness; instead, N addition continued to decrease
 ecosystem stability by decreasing species dominance and stability of the
 dominant species, without changing the identity of the dominant species.
 4. Synthesis. Our results indicate that N addition decreased ecosystem
 stability via mechanisms that were both dependent and independent of plant
 diversity, and that the mechanisms involved shifted over time. N addition
 impacted on ecosystem functioning through species richness and the effects
 on species dominance and the stability of most dominant species,
 highlighting the join effect of multiple biotic drivers in regulating
 ecosystem stability.
description: Nitrogen addition
 reduced ecosystem stability regardless of its impacts on plant
 diversityThis data file contains
 plot-level data, including nitrogen (ambient nitrogen, nitrogen addition)
 and litter treatments (litter removal, initial litter, litter addition),
 and variables ecosystem stability, dominant species stability, subordinate
 species stability, species richness, dominance ratio index, species
 asynchrony and ANPP (g m-2), for the periods 2010-2013, 2014-2016 and
 2010-2016.Data.xlsx
DOI: 10.5061/dryad.2t14h9r
title: Data from: Responses of biomass allocation across two vegetation types to climate fluctuations in the northern Qinghai-Tibet Plateau

description: The Qinghai-Tibet Plateau (QTP) is particularly sensitive to global
 climate change, especially to elevated temperatures, when compared with
 other ecosystems. However, few studies use long-term field measurements to
 explore the interannual variations in plant biomass under climate
 fluctuations. Here, we examine the interannual variations of plant biomass
 within two vegetation types (alpine meadow and alpine shrub) during
 2008-2017 and their relationships with climate variables. The following
 results were obtained. The aboveground biomass (AGB) and belowground
 biomass (BGB) response differently to climate fluctuations, the AGB in KPM
 was dominated by mean annual precipitation (MAP), whereas the AGB in PFS
 was controlled by mean annual air temperature (MAT). However, the BGB of
 both KPM and PFS was only weakly affected by climate variables, suggesting
 that the BGB in alpine ecosystems may remain as a stable carbon stock even
 under future global climate change. Furthermore, the AGB in PFS was
 significantly higher than KPM, while the BGB and R/S in KPM were
 significantly higher than PFS, reflecting the KPM be more likely to
 allocate more photosynthates to roots. Interestingly, the proportion of
 0-10 cm root biomass increased in KPM and PFS, whereas the other
 proportions both decreased, reflecting a shift in biomass towards the
 surface layer. Our results could provide a new sight for the prediction
 how alpine ecosystem response to future climate change.
description: The biomass and climate
 dataData.xlsx
DOI: 10.5061/dryad.412jp56
title: Data from: Destruction of spider webs and rescue of ensnared nestmates by a granivorous desert ant (Veromessor pergandei)

description: Prey species rarely seek-out and dismantle traps constructed by their
 predators. In the current study, we report an instance of targeted trap
 destruction by an invertebrate, and a novel context for rescue behavior.
 We found that foragers of the granivorous desert ant, Veromessor
 pergandei, identify and cooperatively dismantle spider webs (Araneae:
 Theridiidae, Steatoda spp. and Asagena sp.) During group foraging, workers
 ensnared in webs are recovered by sisters, who transport them to the nest
 and groom away their silk bindings. The presence of an ensnared nestmate
 and chemical alarm signal significantly increased the probability of web
 removal and nestmate retrieval. A subset of larger-bodied foragers
 participated in web removal, and 6.3% became tangled or were captured by
 spiders. Most animals that perform rescue behavior live in small groups,
 but V. pergandei colonies include tens of thousands of short-lived
 workers. To maintain their size, large colonies must collect enough seeds
 to produce 650 new ants each day. We hypothesize that the removal of
 spider webs allows for an unimpeded income of seeds on a single foraging
 path, during a brief daily temperature window. Despite the cost to
 individuals, webs are only recognized and removed when workers are
 captured in them.
description: Data for Table A1, silk
 removal in a natural contextThese data show the
 presence or absence of factors associated with 29 spider webs found on
 Veromessor pergandei foraging columns and nest mounds. For each variable,
 0 = no, 1 = yes. The statistical analysis of this data set is presented in
 Table A1.Silk removal observations, Data
 for Table A1.csvData for Table A2,
 Silk-gland-dummy assayData represent the
 number of workers responding to 5 different stimuli, across 16 field
 colonies. The statistical analysis of this data set is presented in Table
 A2.Silk-gland-dummy assay, Data
 for Table A2.csvData for Wilcoxon ranked
 sign test, head vs gaster gland assay,Data represent worker
 responses to each of 3 stimuli, presented to 30 unique colonies. Paired
 responses to head and gaster contents were compared with a Wilcoxon ranked
 sign test for 28/30 unique pairs.Head vs gaster gland assay,
 Wilcoxon ranked sign test.csv
DOI: 10.5061/dryad.md4s537
title: Data from: Dissolved iron elution from mangrove ecosystem associated with polyphenols and a herbivorous snail

description: Interest in the systems supplying dissolved forms of iron to the sea from
 upland-forests and wetlands has increased because iron is abundant on land
 but has low bioavailability in seawater. This can be a limiting factor for
 the growth of marine phytoplankton. Organic complex iron, a typical form
 of iron dissolved in seawater, is supplied to the ocean through rivers
 from forest and wetland soils. As a related study, we focus on mangrove
 ecosystems located at the boundary between the land and sea and on
 polyphenols present in leaves as ligands for the formation of iron
 complexes. When mangrove leaf litter falls on the wet forest floor,
 phenolic compounds leach out from the leaves and might solubilize
 insoluble iron in the sediments (i.e., iron complexation). However, the
 reaction mechanism is not simple in the field, and it might be made more
 complex by tidal currents and intervention by crabs and snails, which
 consume mangrove leaf litter. In the present study, we focused on a
 detritivorous snail, Terebralia palustris, as a facilitator of iron
 solubilization associated with phenolic compounds, and examined how the
 snail contribute to iron solubilization processes. Our results indicated
 that the amounts of phenolic compounds in mangrove sediments are strongly
 related to iron solubilization. Furthermore, the average dissolved iron
 and phenolic contents in sediments from areas inhabited by the snail were
 significantly higher than those of sediments where the snail was not
 present. We additionally report that the solubilization of iron was
 promoted when snail feces were added to mangrove sediments. In conclusion,
 we propose that iron solubilization in mangrove sediments is promoted by
 the interaction between i) iron in the sediment, ii) phenolic compounds
 derived from mangroves, and iii) the consumption of leaves and the
 deposition of feces by the snail.
description: Hinokidani and Nakanishi
 2019aAnalytical data on
 hydrogen ion content (pH), phenolics and dissolved iron of sediment
 samples.
DOI: 10.5061/dryad.159h65k
title: Data from: A novel open access web portal for integrating mechanistic and toxicogenomic study results

description: Applying toxicogenomics to improving the safety profile of drug candidates
 and crop protection molecules is most useful when it identifies relevant
 biological and mechanistic information that highlights risks and informs
 risk mitigation strategies. Pathway-based approaches, such as GSEA,
 integrate toxicogenomic data with known biological process and pathways.
 Network methods help define unknown biological processes and offer data
 reduction advantages. Integrating the two approaches would improve
 interpretation of toxicogenomic information. Barriers to the routine
 application of these methods in genome-wide transcriptomic studies include
 a need for “hands-on” computer programming experience, the selection of
 one or more analysis methods (e.g. pathway analysis methods), the
 sensitivity of results to algorithm parameters, and challenges in linking
 differential gene expression to variation in safety outcomes. To
 facilitate adoption and reproducibility of gene expression analysis in
 safety studies, we have developed Collaborative Toxicogenomics (CTox), an
 open-access integrated web portal using the Django web framework. The
 software, developed with the Python programming language, is modular,
 extensible and implements “best-practice” methods in computational
 biology. New study results are compared to over 4,000 rodent liver
 experiments from Drug Matrix and open TG-GATEs. A unique feature of the
 software is the ability to integrate clinical chemistry and
 histopathology-derived outcomes with results from gene expression studies,
 leading to relevant mechanistic conclusions. We describe its application
 by analyzing the effects of several toxicants on liver gene expression and
 exemplify application to predicting toxicity study outcomes upon chronic
 treatment from expression changes in acute-duration studies.
description: Datasets from A novel
 open access web portal for integrating mechanistic and toxicogenomic study
 resultsData in Excel format as
 cited in A novel open access web portal for integrating mechanistic and
 toxicogenomic study resultsctox
 supporting_data_toxsci_rev.xlsx
DOI: 10.18167/dvn1/8lig1d
title: BVLAC corpus - Extracted Data
title: Corpus BVLAC - Données extraites

description: [FR] Dans le cadre du projet SONGES sur la mise en correspondance de données textuelles massives et hétérogènes, nous élaborons des modèles de représentation de données ainsi que des mesures de similarité à partir d’indicateurs trouvés dans les textes (thématiques, spatiaux et temporels). L’objectif est d’organiser et valoriser des ensembles de données dans leurs dimensions hétérogènes et massives. Parmi les données exploitées, nous travaillons sur un ensemble de données produites dans le cadre du projet BVLAC, un projet mené par le CIRAD qui promeut des techniques agricoles issues de l’agroécologie à Madagascar. 
&lt;br&gt;
Ce dépôt rassemble les données brutes extraites à partir du corpus BVLAC. Les données contenus dans l'archive sont :
&lt;ul&gt;
 &lt;li&gt;Les données pour chaque document (*.txt)&lt;/li&gt;
 &lt;li&gt;dans "association‧json" : le nom des fichiers originaux pour chaque identifiant&lt;/li&gt;
 &lt;li&gt;dans "association_lang‧json" : langue utilisée dans chaque document&lt;/li&gt;
&lt;/ul&gt;
&lt;br&gt;
[EN] As part of the SONGES project on the matching of massive and heterogeneous textual data, we are developing data representation models and similarity measures based on indicators found in the texts (thematic, spatial and temporal). The objective is to organize and valorize data sets in their heterogeneous and massive dimensions. Among the data used, we are working on a dataset produced as part of the BVLAC project, a project led by CIRAD that promotes agricultural techniques derived from agroecology in Madagascar. 
&lt;br&gt;
This repository contains the raw data extracted from the BVLAC corpus. The data contained in the archive are:
&lt;ul&gt;
 &lt;li&gt;Data for each document (*.txt)&lt;/li&gt;
 &lt;li&gt;in "association‧json" : the name of the original files for each identifier&lt;/li&gt;
 &lt;li&gt;in "association_lang‧json" : language used in each document&lt;/li&gt;
&lt;/ul&gt;
DOI: 10.5061/dryad.jp55n53
title: Data from: Long-term heavy reindeer grazing promotes plant phosphorus limitation in arctic tundra

description: 1. The potential of large mammalian herbivores to shift plant communities
 between nitrogen (N) and phosphorus (P) limitation has received little
 attention so far. However, herbivores can influence the cycling of these
 growth-limiting nutrients, and thereby affect plant nutrient limitation
 and productivity. Tundra ecosystems are nutrient-poor and commonly grazed
 by large herbivores like reindeer and may thus be responsive to such
 changes. 2. Here we examined the effect of long-term light and heavy
 reindeer grazing on nutrient limitation of plant growth in a Scandinavian
 arctic tundra. We are the first to conduct a factorial N and P
 fertilization experiment across the two grazing regimes in two
 functionally contrasting vegetation types: heath and meadow. 3. Annual
 primary productivity (APP) showed contrasting responses to our
 fertilization treatments under light and heavy grazing. Under light
 grazing, APP increased in response to N + P additions in both the heath
 and meadow. Under heavy grazing, APP increased in response to N in the
 heath, with an additional positive effect of N + P combined, while APP
 increased in response to P and N + P additions in the meadow. 4. These
 results clearly show that an increase in the grazing intensity of reindeer
 facilitated a shift towards more P limited conditions in Scandinavian
 arctic tundra, by increasing N cycling without having a corresponding
 positive effect on P cycling. In the N-poor heath, reindeer increased soil
 N availability at least partly due to a shift towards more N-rich
 graminoids, while in the meadow reindeer decreased soil P availability.
 The mechanisms behind this decrease remain unclear, but reindeer may
 simply export more P from the system than N due to their large P demand
 for the production of their antlers. 5. Synthesis. We conclude that heavy
 and long-term reindeer grazing promoted a more P limited tundra, thus
 experimentally confirming the potential of large mammalian herbivores to
 influence nutrient limitation of plant growth.
description: Annual Primary
 Productivity data from NP fertilization experimentThe datafile contains 2
 sheets, the first sheet contains the metadata and the second sheet
 contains the actual data. The data are from a full-factorial nitrogen (N)
 and phosphorus (P) addition experiment performed in the artic tundra in
 two contrasting vegetation types (heath and meadow) under two contrasting
 reindeer grazing regimes (lightly and heavily grazed). We collected data
 on annual primary productivity (in g per m2) of 4 different plant
 functional types (deciduous shrubs, evergreen shrubs, forbs,
 graminoids).Fertilization
 experiment_APP.xlsxR script used for the
 statistical analysesThis document contains
 the R script used for the statistical analyses of the paper:
 'Long-term heavy reindeer grazing promotes plant phosphorus
 limitation in arctic tundra' by Sitters et al.Rscript_Fertilization
 experiment_Sitters.docx
DOI: 10.5061/dryad.q83g0bv
title: Data from: Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model

description: The glycocalyx has been identified as a key mechanosensor of the shear
 forces exerted by the streaming blood onto the vascular endothelial
 lining. Although the biochemical reaction to the blood flow has been
 extensively studied, the mechanism of transmission of the hemodynamic
 shear forces to the endothelial transmembrane anchoring structures and,
 consequently, to the subcellular elements in the cytoskeleton, is still
 not fully understood. Here we apply a multiscale approach to elucidate how
 hemodynamic shear forces are transmitted to the transmembrane anchors of
 endothelial cells. Wall shear stress time histories, as obtained from
 image-based computational hemodynamics models of a carotid bifurcation,
 are used as a load and a continuum model is applied to obtain the
 mechanical response of the glycocalyx all along the cardiac cycle. The
 main findings of this in silico study are that: (1) the forces transmitted
 to the transmembrane anchors are in the range of 1-10 pN, which is in the
 order of magnitude reported for the different conformational states of
 transmembrane mechanotranductors; (2) locally, the forces transmitted to
 the anchors of the glycocalyx structure can be markedly different from the
 near-wall hemodynamic shear forces both in amplitude and frequency
 content. Despite the continuum assumption adopted in this study, the
 findings of this in silico approach warrant future studies focusing on the
 actual forces transmitted to the transmembrane mechanotrasductors, which
 might outperform hemodynamic descriptors of disturbed shear as localizing
 factors of vascular disease.
description: online_data_descriptorsenergiesCode to compute transmission quantities based on the WSS
DOI: 10.5061/dryad.3tq2v6m
title: Data from: Satellite image texture for the assessment of tropical anuran communities

description: The relationship between environmental heterogeneity and biodiversity
 represents a cornerstone of ecological research. While environmental
 descriptors over large extents usually have medium to low spatial
 resolution, in-situ measures provide accurate information for limited
 areas, and a gap remains in providing remote descriptors that represent
 local environmental structure. Texture from satellite images can represent
 fine-scale heterogeneity over wide spatial coverage, but to date, it has
 mostly been used to predict general aspects of species diversity, such as
 richness. Here, we assess the utility of image textures from high
 resolution satellite images (RapidEye 3A) and in-situ variables to predict
 differences in the composition of anuran communities in a tropical savanna
 (Cerrado) of Brazil. While in-situ measures accounted for compositional
 differences of the whole community, two measures of image textures were
 associated only with the variation of species within the Hylidae family
 (adj. R² = 0.16 and 0.14). Comparatively, image textures predicted ~2/3 of
 the variation explained by in-situ­ measures (adj. R² = 0.23). When both
 approaches were combined, a greater compositional variation was achieved
 (adj. R² = 0.28), with 1/5 of it shared by both in-situ and textures, and
 1/5 attributed solely to texture. Our findings suggest that image texture
 can complement the assessment of environmental heterogeneity acting on the
 assembly of local anuran communities. This approach can be valuable for
 explicitly including spatial heterogeneity in biological assessments over
 broad spatial extents, especially for biological groups strongly filtered
 by environmental conditions.
description: DatabaseDataset used in the manuscriptdata.zip