cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20324233
title: Chronic Lymphocytic Leukemia (CLL): evaluation of AKT protein kinase and microRNA gene expression related to disease pathogenesis

description: Abstract The present study evaluated 56 patients diagnosed with Chronic Lymphocytic Leukemia (CLL) and a control group of 44 clinically healthy subjects with no previous history of leukemia. Genetic expressions of AKT and microRNAs were evaluated by quantitative PCR (qPCR). A significant increase in AKT gene expression in patients when compared to controls was observed (p = 0.017). When the patients were stratified according to Binet subgroups, a significant difference was observed between the subgroups, with this protein kinase appearing more expressed in the B+C subgroup (p = 0.013). Regarding miRNA expression, miR-let-7b and miR-26a were reduced in CLL patients, when compared to controls. However, no significant differences were observed in these microRNA expressions between the Binet subgroups (A versus B+C). By contrast, miR-21 to miR-27a oncogenes showed no expression difference between CLL patients and controls. AKT protein kinase is involved in the signaling cascade that occurs with BCR receptor activation, leading to increased lymphocyte survival and protection against the induction of cell death in CLL. Thus, increased AKT protein kinase expression and the reduction of miR-let-7b and miR-26a, both tumor suppressors, may explain increased lymphocyte survival in CLL patients and may be promising markers for the prognostic evaluation of this disease.
DOI: 10.6084/m9.figshare.20324233.v1
title: Chronic Lymphocytic Leukemia (CLL): evaluation of AKT protein kinase and microRNA gene expression related to disease pathogenesis

description: Abstract The present study evaluated 56 patients diagnosed with Chronic Lymphocytic Leukemia (CLL) and a control group of 44 clinically healthy subjects with no previous history of leukemia. Genetic expressions of AKT and microRNAs were evaluated by quantitative PCR (qPCR). A significant increase in AKT gene expression in patients when compared to controls was observed (p = 0.017). When the patients were stratified according to Binet subgroups, a significant difference was observed between the subgroups, with this protein kinase appearing more expressed in the B+C subgroup (p = 0.013). Regarding miRNA expression, miR-let-7b and miR-26a were reduced in CLL patients, when compared to controls. However, no significant differences were observed in these microRNA expressions between the Binet subgroups (A versus B+C). By contrast, miR-21 to miR-27a oncogenes showed no expression difference between CLL patients and controls. AKT protein kinase is involved in the signaling cascade that occurs with BCR receptor activation, leading to increased lymphocyte survival and protection against the induction of cell death in CLL. Thus, increased AKT protein kinase expression and the reduction of miR-let-7b and miR-26a, both tumor suppressors, may explain increased lymphocyte survival in CLL patients and may be promising markers for the prognostic evaluation of this disease.
DOI: 10.6084/m9.figshare.20324236
title: Hematological Parameters to Predict the Severity of Hyperemesis Gravidarum and Ketonuria

description: Abstract Objective Hyperemesis gravidarum (HG) is a pregnancy complication that can progress with persistent nausea and vomiting. The aim of the present study is to evaluate the relationship between hematological parameters and HG. Method A total of 532 pregnant women with HG who were admitted to the Department of Obstetrics and Gynecology between March 2019 and February 2021, and 534 healthy pregnant women with characteristics similar to those of the case group were included in the study. The hematological parameters of both groups were compared. In addition, the hematological parametersof patients with HG according to the severity of ketonuria were compared. Results Themean age of the HG group (n=532) was 26.3 ± 4.1 years, and that of the control group (n=534) was 25.9 ± 4.8 years. Among patients with HG, 46% (n=249) had ketone(+), 33% (n=174), ketone(++), and 21% (n=109), ketone(+++). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were higher in the HG group than in the control group: 3.8 (2.8-5.8)/3.2 (2.6-4.0); p&lt;0.001; and 135.2 ± 30.4/108.9 ± 62.2; p&lt;0.001 respectively. The neutrophil count, NLR, and PLR were higher in the group with ketone(+++) than in the groups with ketone(+) or ketone(++): 7.6 ± 1.9/5.5 ± 2.4; p&lt;0.001; 3.8(2.8-4.6)/2.9(2.3- 3.6); p&lt;0.001; and 149.9 ± 48.0/135.9 ± 65.7; p&lt;0.001 respectively. The mean corpuscular hemoglobin (MCH) level, the NLR, and the PLR were identified as independent predictors of the presence of HG and the level of ketone positivity in HG patients. Conclusion The NLR and PLR were high in patients with HG, suggesting the its inflammatory activity. They may be important markers associated with the presence and severity of HG.
DOI: 10.6084/m9.figshare.20324236.v1
title: Hematological Parameters to Predict the Severity of Hyperemesis Gravidarum and Ketonuria

description: Abstract Objective Hyperemesis gravidarum (HG) is a pregnancy complication that can progress with persistent nausea and vomiting. The aim of the present study is to evaluate the relationship between hematological parameters and HG. Method A total of 532 pregnant women with HG who were admitted to the Department of Obstetrics and Gynecology between March 2019 and February 2021, and 534 healthy pregnant women with characteristics similar to those of the case group were included in the study. The hematological parameters of both groups were compared. In addition, the hematological parametersof patients with HG according to the severity of ketonuria were compared. Results Themean age of the HG group (n=532) was 26.3 ± 4.1 years, and that of the control group (n=534) was 25.9 ± 4.8 years. Among patients with HG, 46% (n=249) had ketone(+), 33% (n=174), ketone(++), and 21% (n=109), ketone(+++). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were higher in the HG group than in the control group: 3.8 (2.8-5.8)/3.2 (2.6-4.0); p&lt;0.001; and 135.2 ± 30.4/108.9 ± 62.2; p&lt;0.001 respectively. The neutrophil count, NLR, and PLR were higher in the group with ketone(+++) than in the groups with ketone(+) or ketone(++): 7.6 ± 1.9/5.5 ± 2.4; p&lt;0.001; 3.8(2.8-4.6)/2.9(2.3- 3.6); p&lt;0.001; and 149.9 ± 48.0/135.9 ± 65.7; p&lt;0.001 respectively. The mean corpuscular hemoglobin (MCH) level, the NLR, and the PLR were identified as independent predictors of the presence of HG and the level of ketone positivity in HG patients. Conclusion The NLR and PLR were high in patients with HG, suggesting the its inflammatory activity. They may be important markers associated with the presence and severity of HG.
DOI: 10.6084/m9.figshare.20324238
title: Comparison of sweep visual evoked potential of visual acuity and Snellen visual acuity in healthy and amblyopic children

description: ABSTRACT Purpose: To evaluate the visual acuity of healthy and amblyopic children using sweep visual evoked potential and compare the results with those of Snellen visual acuity testing. Methods: A total of 160 children aged 6-17 years were included in the study. Of these, 104 (65%) were aged 7-17 years old, able to verbally communicate, and did not have any systemic or ocular pathology (Group 1). Group 2 included 56 (35%) children aged 6-17 years, able to verbally communicate, and had strabismus or anisometropic amblyopia whose best corrected visual acuity was between 0.1 and 0.8. All subjects underwent a detailed ophthalmological examination and sweep visual evoked potential measurement. Demographic characteristics, ocular findings, best corrected visual acuity, and sweep visual evoked potential results were recorded. Results: In Group 1, the mean and maximum visual acuity values for sweep visual evoked potential were lower than the Snellen best corrected visual acuity (p&lt;0.001, for both, respectively). Bland-Altman analysis revealed that in Group 1, the distribution of the differences between the Snellen best corrected visual acuity and mean sweep visual evoked potential visual acuity was ±0.11 logMAR, and the distribution of the differences between the Snellen best corrected visual acuity and maximum sweep visual evoked potential visual acuity was ±0.023 logMAR. In Group 2, the mean and maximum sweep visual evoked potential visual acuity were lower than the Snellen best corrected visual acuity (p&lt;0.001 and p=0.009, respectively). Bland-Altman analysis revealed that the distribution of the differences between the Snellen best corrected visual acuity and mean sweep visual evoked potential visual acuity was ±0.16 logMAR, and the distribution of the differences between the Snellen best corrected visual acuity and maximum sweep visual evoked potential visual acuity was ±0.19 logMAR. Conclusions: Sweep visual evoked potential visual acuity measurements have comparable results with Snellen visual acuity measurements. This technique is an objective and reliable method for evaluating visual acuity in children.
DOI: 10.6084/m9.figshare.20324238.v1
title: Comparison of sweep visual evoked potential of visual acuity and Snellen visual acuity in healthy and amblyopic children

description: ABSTRACT Purpose: To evaluate the visual acuity of healthy and amblyopic children using sweep visual evoked potential and compare the results with those of Snellen visual acuity testing. Methods: A total of 160 children aged 6-17 years were included in the study. Of these, 104 (65%) were aged 7-17 years old, able to verbally communicate, and did not have any systemic or ocular pathology (Group 1). Group 2 included 56 (35%) children aged 6-17 years, able to verbally communicate, and had strabismus or anisometropic amblyopia whose best corrected visual acuity was between 0.1 and 0.8. All subjects underwent a detailed ophthalmological examination and sweep visual evoked potential measurement. Demographic characteristics, ocular findings, best corrected visual acuity, and sweep visual evoked potential results were recorded. Results: In Group 1, the mean and maximum visual acuity values for sweep visual evoked potential were lower than the Snellen best corrected visual acuity (p&lt;0.001, for both, respectively). Bland-Altman analysis revealed that in Group 1, the distribution of the differences between the Snellen best corrected visual acuity and mean sweep visual evoked potential visual acuity was ±0.11 logMAR, and the distribution of the differences between the Snellen best corrected visual acuity and maximum sweep visual evoked potential visual acuity was ±0.023 logMAR. In Group 2, the mean and maximum sweep visual evoked potential visual acuity were lower than the Snellen best corrected visual acuity (p&lt;0.001 and p=0.009, respectively). Bland-Altman analysis revealed that the distribution of the differences between the Snellen best corrected visual acuity and mean sweep visual evoked potential visual acuity was ±0.16 logMAR, and the distribution of the differences between the Snellen best corrected visual acuity and maximum sweep visual evoked potential visual acuity was ±0.19 logMAR. Conclusions: Sweep visual evoked potential visual acuity measurements have comparable results with Snellen visual acuity measurements. This technique is an objective and reliable method for evaluating visual acuity in children.
DOI: 10.6084/m9.figshare.20324241
title: Political effects on the discontinuation of participatory budgeting in municipalities

description: Abstract The article analyzes the factors associated with the discontinuation of participatory budgeting (PB) in Brazilian municipalities with more than 50,000 inhabitants between 2000 and 2016. We used econometric models to estimate PB’s discontinuation based on political explanatory variables and people’s local participation. The results indicate that discontinuation is associated: (i) positively with the election of a different local government, regardless of the winning party’s ideology; (ii) positively with the election of a local government with a left-wing ideology’; (iii) negatively with the election of a non-left-wing local government; (iv) positively with the election of a left-wing local government replacing another left-wing government. Changes in local government where other non-left-wing parties replace non-left-wing parties had no significant effect on discontinuation. The results contribute to our knowledge by showing the local and contextual factors that explain the discontinuation of participatory budgeting; this should help guide the design of participatory public policies and allow practitioners to reflect on the mechanisms that could be adopted locally to avoid discontinuation. The article also contributes to the literature by demonstrating the association between discontinuation and changes in left-wing local governments, which may prompt future research, given the unexpected result.
DOI: 10.6084/m9.figshare.20324241.v1
title: Political effects on the discontinuation of participatory budgeting in municipalities

description: Abstract The article analyzes the factors associated with the discontinuation of participatory budgeting (PB) in Brazilian municipalities with more than 50,000 inhabitants between 2000 and 2016. We used econometric models to estimate PB’s discontinuation based on political explanatory variables and people’s local participation. The results indicate that discontinuation is associated: (i) positively with the election of a different local government, regardless of the winning party’s ideology; (ii) positively with the election of a local government with a left-wing ideology’; (iii) negatively with the election of a non-left-wing local government; (iv) positively with the election of a left-wing local government replacing another left-wing government. Changes in local government where other non-left-wing parties replace non-left-wing parties had no significant effect on discontinuation. The results contribute to our knowledge by showing the local and contextual factors that explain the discontinuation of participatory budgeting; this should help guide the design of participatory public policies and allow practitioners to reflect on the mechanisms that could be adopted locally to avoid discontinuation. The article also contributes to the literature by demonstrating the association between discontinuation and changes in left-wing local governments, which may prompt future research, given the unexpected result.
DOI: 10.6084/m9.figshare.20324244
title: Impact of SARS-CoV-2 pandemic on ophthalmological emergency visits: 1 year of experience

description: ABSTRACT Purpose: The COVID-19 pandemic began in March 2020 and changed the healthcare system overall. The pandemic led to resource allocation changes, overloading of intensive care units, apprehensiveness of patients to seek medical care not related to COVID-19, and an abrupt reduction in all nonurgent consultations and surgeries. This study evaluated the impact on an ophthalmological emergency room for one year by assessing the correlation between societal lockdown phases and COVID-19 mortality. Methods: An observational, retrospective study was conducted that included all patients admitted to the Ophthalmology Emergency Department between January 1, 2019, and March 28, 2021. The visits were classified into prepandemic and pandemic groups that were then compared. Results: In the prepandemic period, the hospital registered a total of 71,485 visits with a mean of 194.78 ± 49.74 daily visits. In the pandemic group, there was a total of 41,791 visits with a mean of 114.18 ± 43.12 daily visits, which was a 41.4% decrease. A significant decrease (16.4 p&lt;0.001) was observed in the prevalence of acute conjunctivitis, and a significant increase (6.4%; p&lt;0.01) was observed in the prevalence of corneal foreign body disorders. A negative correlation was identified between the COVID-19 death rate and the ophthalmological inflow rates. Conclusion: This one-year analysis showed a reduction of 41.4% in emergency department visits and a significant decrease in infectious conditions. A change in hygiene habits and social distancing could explain this reduction, and the increased prevalence of trauma consultations highlighted the need for preventive and educative measures during these types of restrictive periods.
DOI: 10.6084/m9.figshare.20324244.v1
title: Impact of SARS-CoV-2 pandemic on ophthalmological emergency visits: 1 year of experience

description: ABSTRACT Purpose: The COVID-19 pandemic began in March 2020 and changed the healthcare system overall. The pandemic led to resource allocation changes, overloading of intensive care units, apprehensiveness of patients to seek medical care not related to COVID-19, and an abrupt reduction in all nonurgent consultations and surgeries. This study evaluated the impact on an ophthalmological emergency room for one year by assessing the correlation between societal lockdown phases and COVID-19 mortality. Methods: An observational, retrospective study was conducted that included all patients admitted to the Ophthalmology Emergency Department between January 1, 2019, and March 28, 2021. The visits were classified into prepandemic and pandemic groups that were then compared. Results: In the prepandemic period, the hospital registered a total of 71,485 visits with a mean of 194.78 ± 49.74 daily visits. In the pandemic group, there was a total of 41,791 visits with a mean of 114.18 ± 43.12 daily visits, which was a 41.4% decrease. A significant decrease (16.4 p&lt;0.001) was observed in the prevalence of acute conjunctivitis, and a significant increase (6.4%; p&lt;0.01) was observed in the prevalence of corneal foreign body disorders. A negative correlation was identified between the COVID-19 death rate and the ophthalmological inflow rates. Conclusion: This one-year analysis showed a reduction of 41.4% in emergency department visits and a significant decrease in infectious conditions. A change in hygiene habits and social distancing could explain this reduction, and the increased prevalence of trauma consultations highlighted the need for preventive and educative measures during these types of restrictive periods.
DOI: 10.6084/m9.figshare.20324245
title: Situational Analysis: Relevant Advances in Grounded Theory for Management Studies

description: Abstract This paper aims at closing a gap in literature referring to academic publications that approach grounded theory, considering that little advance has been noticed in discussions that encompass the application of situational analysis (SA) proposed by Clarke (2003, 2005) and Clarke, Friese and Washburn (2018) in management studies. Thus, this conceptual paper seeks to address situational analysis considering its ontological and epistemological aspects, to investigate its operationalization forms, and, finally, to indicate relevant situational analysis issues for management studies. Our discussion sheds light on relevant situational analysis aspects, which helps prioritizing research methods that may contribute to create fairer and more effective social policies in several fields and meeting daily demands of the management field. As a conclusion, situational analysis seems to bring new guidance to grounded theory after the interpretive turn: cartographic method, consideration of human and non-human actors, and social commitments; in addition, situational analysis gathers discourse and agency studies, action and structure, image, text and context, history, and the present moment to analyze complex investigations.
DOI: 10.6084/m9.figshare.20324245.v1
title: Situational Analysis: Relevant Advances in Grounded Theory for Management Studies

description: Abstract This paper aims at closing a gap in literature referring to academic publications that approach grounded theory, considering that little advance has been noticed in discussions that encompass the application of situational analysis (SA) proposed by Clarke (2003, 2005) and Clarke, Friese and Washburn (2018) in management studies. Thus, this conceptual paper seeks to address situational analysis considering its ontological and epistemological aspects, to investigate its operationalization forms, and, finally, to indicate relevant situational analysis issues for management studies. Our discussion sheds light on relevant situational analysis aspects, which helps prioritizing research methods that may contribute to create fairer and more effective social policies in several fields and meeting daily demands of the management field. As a conclusion, situational analysis seems to bring new guidance to grounded theory after the interpretive turn: cartographic method, consideration of human and non-human actors, and social commitments; in addition, situational analysis gathers discourse and agency studies, action and structure, image, text and context, history, and the present moment to analyze complex investigations.
DOI: 10.6084/m9.figshare.20324247
title: Integrated Reporting and Value Creation: the Semantics of the Fundamental Concept of Integrated Reporting

description: Abstract The objective of this research is to build the semantics of the concept of value creation based on the existing literature, delimited to the Integrated Reporting (IR) proposal. It is a descriptive, bibliographic and documentary study, developed with use of content analysis. Sixteen articles, three books and one document were analyzed, based on the “Value Creation – Background Paper” (International Integrated Reporting Council, 2013a), as well as on the semantic classification proposed by Ilari and Geraldi (1985). The results show that the semantics of the concept of value creation is that the organization carries out actions of values (capitals) created directly or indirectly, considering only their positive effect on society and the environment. Negative actions cause value destruction for shareholders and stakeholders, and they are not reported when expected to be. Financial value is relevant, but not enough to create value. The absence of explanations on the subject makes it possible the non-adoption of the real purpose in the construction of the connectivity of financial and non-financial information, consequently damaging the credibility of this new corporate disclosure format. The research encourages discussions to fill gaps and counter criticisms, especially international ones. It contributes to the interpretation of the concept of value creation for future IR disclosures, clearly elucidating what would be the organization’s value creation and accountability to society, in view of the difficulty in applying this concept in public consultations (2013 and 2017), as revealed by preparers. This research also contributes to advancing the discussion in the literature in the value creation context.