cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5126323
title: Supplementary Material for: Oculopalatal Tremor: Variations on a Theme by Guillain and Mollaret

description: <b><i>Background:</i></b> Oculopalatal tremor (OPT) is a delayed complication of a brainstem lesion, characterized by involuntary contractions of the soft palate associated with a synchronized ocular pendular nystagmus. MRI reveals inferior olivary nucleus hypersignal/hypertrophy (IONH). Our objective was to refine the clinical profile of patients with OPT and to report a few oddities in both presentation and evolution. <b><i>Methods:</i></b> We performed a retrospective study of patients diagnosed with OPT and a literature search. <b><i>Results:</i></b> From our database, we retrieved 5 men and 3 women with a diagnosis of OPT. Eighty-two patients with OPT were retrieved from the literature and were compiled with our series. The average age was 54 years and there was a male predominance. Brainstem vascular lesion was the most common etiology (80%). Prominent vertical pendular nystagmus was found in 90%. Dissociated nystagmus was mostly associated to unilateral contralateral IONH on MRI, while bilateral symmetrical nystagmus was due to a bilateral IONH in the majority of cases. Three oddities were found amongst our 8 patients: prominent nystagmus ipsilateral to IONH; disappearance of IONH on MRI despite persisting nystagmus, and asymptomatic OPT. <b><i>Conclusion:</i></b> The clinical profile of OPT is rather stereotyped. Rarely do patients deviate from the classical description of OPT.
DOI: 10.6084/m9.figshare.5126320.v1
title: Supplementary Material for: High Penetrance of a Pan-<b><i>Canina</i></b> Type rDNA Family in Intersection <b><i>Rosa</i></b> Hybrids Suggests Strong Selection of Bivalent Chromosomes in the Section <b><i>Caninae</i></b>

description: All dogroses <i>(Rosa</i> sect. <i>Caninae)</i> are characterized by the peculiar <i>canina</i> meiosis in which genetic material is unevenly distributed between female and male gametes. The pan-<i>canina</i> rDNA family (termed beta) appears to be conserved in all dogroses analyzed so far. Here, we have studied rDNAs in experimental hybrids obtained from open pollination of F1 plants derived from 2 independent intersectional crosses between the pentaploid dogrose species (2n = 5x = 35) <i>Rosa rubiginosa</i> as female parent (producing 4x egg cells due to the unique asymmetrical <i>canina</i> meiosis) and the tetraploid (2n = 4x = 28) garden rose <i>R. hybrida</i> ‘André Brichet' as male parent (producing 2x pollen after normal meiosis). We analyzed the structure of rDNA units by molecular methods [CAPS and extensive sequencing of internal transcribed spacers (ITS)] and determined the number of loci on chromosomes by FISH. FISH showed that <i>R. rubiginosa</i> and ‘André Brichet' harbored 5 and 4 highly heteromorphic rDNA loci, respectively. In the second generation of hybrid lines, we observed a reduced number of loci (4 and 5 instead of the expected 6). In <i>R. rubiginosa</i> and ‘André Brichet', 2-3 major ITS types were found which is consistent with a weak homogenization pressure maintaining high diversity of ITS types in this genus. In contrast to expectation (the null hypothesis of Mendelian inheritance of ITS families), we observed reduced ITS diversity in some individuals of the second generation which might derive from self-fertilization or from a backcross to <i>R. rubiginosa</i>. In these individuals, the pan-<i>canina</i> beta family appeared to be markedly enriched, while the paternal families were lost or diminished in copies. Although the mechanism of biased meiotic transmission of certain rDNA types is currently unknown, we speculate that the bivalent-forming chromosomes carrying the beta rDNA family exhibit extraordinary pairing efficiency and/or are subjected to strong selection in <i>Caninae</i> polyploids.
DOI: 10.6084/m9.figshare.5126323.v1
title: Supplementary Material for: Oculopalatal Tremor: Variations on a Theme by Guillain and Mollaret

description: <b><i>Background:</i></b> Oculopalatal tremor (OPT) is a delayed complication of a brainstem lesion, characterized by involuntary contractions of the soft palate associated with a synchronized ocular pendular nystagmus. MRI reveals inferior olivary nucleus hypersignal/hypertrophy (IONH). Our objective was to refine the clinical profile of patients with OPT and to report a few oddities in both presentation and evolution. <b><i>Methods:</i></b> We performed a retrospective study of patients diagnosed with OPT and a literature search. <b><i>Results:</i></b> From our database, we retrieved 5 men and 3 women with a diagnosis of OPT. Eighty-two patients with OPT were retrieved from the literature and were compiled with our series. The average age was 54 years and there was a male predominance. Brainstem vascular lesion was the most common etiology (80%). Prominent vertical pendular nystagmus was found in 90%. Dissociated nystagmus was mostly associated to unilateral contralateral IONH on MRI, while bilateral symmetrical nystagmus was due to a bilateral IONH in the majority of cases. Three oddities were found amongst our 8 patients: prominent nystagmus ipsilateral to IONH; disappearance of IONH on MRI despite persisting nystagmus, and asymptomatic OPT. <b><i>Conclusion:</i></b> The clinical profile of OPT is rather stereotyped. Rarely do patients deviate from the classical description of OPT.
DOI: 10.6084/m9.figshare.5126326.v1
title: High-level prediction signals in a low-level area of the macaque face-processing hierarchy

description: Data for Schwiedrzik & Freiwald, 2017<br><br>Electrophysiology:<br>electrophys.mat and electrophys.xlsx<br><br>Contains average spike density functions per neuron (80) and per condition (4) in the time range 50:450 ms (the time range analyzed in the paper) for successor stimuli. Sampling rate is 1000 Hz. The order of conditions is: identity violation, view violation, identity+view violation, trained. Data are available as Matlab (.mat) and Excel (.xlsx) files. <br><br>Psychophysics:<br>psychophys.mat and psychophys.xlsx<br><br>Contains d-prime and average reaction times per subject (13) and per condition (4). The order of conditions is: trained, view violation, identity violation, identity+view violation. Data are available as Matlab (.mat) and Excel (.xlsx) files. <br><br><br>For questions, please contact<br>Caspar M. Schwiedrzik, c.schwiedrzik@eni-g.de<br><br>
DOI: 10.6084/m9.figshare.5126314
title: Supplementary Material for: Survey on the Current Trends in Managing Intrauterine Growth Restriction

description: <b><i>Objective:</i></b> To provide a snapshot of the current trends in managing intrauterine growth restriction (IUGR) and to assess the agreement on the gestational age and the way of delivery in different clinical scenarios. <b><i>Methods:</i></b> A PubMed search was performed to identify all original articles on IUGR in the last 6 years. The most active 20 authors were selected as experts and were invited to respond to a survey on their preferred gestational age for elective delivery in several IUGR cases depending on Doppler measurements (including umbilical artery (UA), middle cerebral artery, cerebroplacental ratio, uterine artery and ductus venosus), biophysical profile and cardiotocography. <b><i>Results:</i></b> 15 of the 20 selected experts agreed to participate in the survey, of which 3 failed to meet the deadline to complete the survey. Management of IUGR was relatively uniform for abnormal UA, uterine artery or cerebroplacental ratio. Although average gestational age at delivery reflected a clear progression with accepted markers of severity, discrepancies of up to 4 weeks were found for abnormal middle cerebral artery Doppler and absent end-diastolic velocity in the UA, and of up to 8 weeks for reverse end-diastolic velocity in the UA and abnormalities in the ductus venosus Doppler. <b><i>Conclusions:</i></b> Management of IUGR is still far from being uniform among centers, with most controversy surrounding the management of early-onset IUGR. There is a need of prospective studies to address this issue.
DOI: 10.6084/m9.figshare.5126305
title: Supplementary Material for: Overweight in Infancy: Which Pre- and Perinatal Factors Determine Overweight Persistence or Reduction A Birth Cohort Followed for 11 Years

description: <b><i>Background:</i></b> A considerable proportion of children with early-life overweight attain a normal weight. To recognize infants at risk of persistent overweight, we compared early-life factors of children with a longitudinal pattern of persistent overweight to children with a pattern of overweight in early but not in later childhood. <b><i>Methods:</i></b> In 3,550 children participating in a birth cohort that started in 1996/1997 in the Netherlands, body mass index was repeatedly assessed until age 11 and dichotomized into with/without overweight. Latent class growth modeling was used to distinguish trajectories. Our analysis was focused on the comparison of early-life factors in children in a persistent overweight pattern with those in an overweight reduction pattern using multivariable log-binomial regression analyses. <b><i>Results:</i></b> Children (n = 133) in the persistent overweight pattern were more likely to have overweight parents [relative risk (RR)<sub>mother</sub>: 1.85, 95% CI: 1.37-2.49: RR<sub>father</sub>: 1.75, 95% CI: 1.21-2.55] than children in the overweight reduction pattern (n = 303). Maternal education, child's gender, ethnicity, birth weight, breast-feeding and maternal smoking during pregnancy did not differ between the trajectories. <b><i>Conclusion:</i></b> Health care practitioners should focus on high-weight infants with overweight parents, as these children are less likely to resolve their overweight.
DOI: 10.6084/m9.figshare.5126308
title: Supplementary Material for: Differential Associations of Dopamine-Related Polymorphisms with Discrete Components of Reaction Time Variability: Relevance for Attention Deficit/Hyperactivity Disorder

description: <b><i>Background:</i></b> Reaction time variability (RTV) is considered a valid endophenotype of attention deficit/hyperactivity disorder (ADHD). It is also often used to examine the efficacy of drug treatment or individual patients' treatment responses and has been furthermore suggested to significantly reduce the potential number of false-positive diagnoses. Among the most commonly investigated candidate genes for ADHD are DRD2, SLC6A3 (DAT), COMT and MAOA. Genetic associations have, however, proven inconclusive or inconsistent. <b><i>Methods:</i></b> Due to the complexity of dopaminergic neurotransmission in the two distinct prosencephalic dopamine pathways, we examined whether the effects of dopamine-related candidate polymorphisms in the genes DRD2, SLC6A3, COMT and MAOA may be differentially associated with discrete subcomponents of RTV, rather than global RTV. A total of 260 healthy volunteers were genotyped for the aforementioned polymorphisms and performed a reaction time paradigm able to distinguish between sensory and motor reaction time. <b><i>Results:</i></b> We found that functional polymorphisms in the genes encoding for dopamine-catabolizing enzymes (i.e. COMT and MAOA) are associated with motor RTV but not with sensory RTV, whereas vice versa the gene DRD2 influences sensory but not motor RTV. No significant associations for the gene SLC6A3 (DAT) were found. <b><i>Conclusions:</i></b> Our results give new insight into the inconsistent state of the literature regarding genetic associations of RTV and clearly show that the examination of subcomponents thereof explains far more variance compared to global RTV. This could be of great relevance to the use of RTV in basic research, clinical diagnostics and pharmacological studies examining the efficacy of novel drug treatments.
DOI: 10.6084/m9.figshare.5126311
title: Supplementary Material for: Birth Weight and Neonatal Adiposity Prediction Using Fractional Limb Volume Obtained with 3D Ultrasound

description: <b><i>Introduction:</i></b> The objective of this investigation was to study fetal thigh volume throughout gestation and explore its correlation with birth weight and neonatal body composition. This novel technique may improve birth weight prediction and lead to improved detection rates for fetal growth restriction. <b><i>Materials and Methods:</i></b> Fractional thigh volume (TVol) using 3D ultrasound, fetal biometry and soft tissue thickness were studied longitudinally in 42 mother-infant pairs. The percentages of neonatal body fat, fat mass and fat-free mass were determined using air displacement plethysmography. Correlation and linear regression analyses were performed. <b><i>Results:</i></b> Linear regression analysis showed an association between TVol and birth weight. TVol at 33 weeks was also associated with neonatal fat-free mass. There was no correlation between TVol and neonatal fat mass. Abdominal circumference, estimated fetal weight (EFW) and EFW centile showed consistent correlations with birth weight. Thigh volume demonstrated an additional independent contribution to birth weight prediction when added to the EFW centile from the 38-week scan (p = 0.03). <b><i>Conclusion:</i></b> Fractional TVol performed at 33 weeks gestation is correlated with birth weight and neonatal lean body mass. This screening test may highlight those at risk of fetal growth restriction or macrosomia.
DOI: 10.6084/m9.figshare.5126302
title: Supplementary Material for: Physical Activity Recommendations in Patients with Chronic Obstructive Pulmonary Disease

description: <b><i>Background:</i></b> Physical activity recommendations are hardly studied in patients with chronic obstructive pulmonary disease (COPD), and specifically recommendations that are individualized to a patient's aerobic fitness level are not studied. <b><i>Objectives:</i></b> To compare individualized (relative) and nonindividualized (absolute) physical activity recommendations in patients with COPD and to assess whether there are differences between patients with mild to moderate and (very) severe COPD. <b><i>Methods:</i></b> We compared 7 different physical activity recommendations that were described in the literature. Four recommendations were individualized based on the patient's aerobic fitness level measured by a maximal cycle ergometer test. Three recommendations were nonindividualized. The recommendations were measured with an accelerometer, pedometer or questionnaire in 115 patients with mild to very severe COPD (68% male, mean age 65 years, mean FEV<sub>1</sub> 58% predicted). <b><i>Results:</i></b> The percentage of patients that met the different recommendations ranged from 22 to 86% and only 8 patients met all 7 recommendations. The agreement between the different recommendations was poor (intraclass correlation coefficient, 0.28). Individualizing the recommendations resulted in a higher number of patients with severe or very severe COPD meeting the individualized recommendations compared to the nonindividualized recommendations. In contrast, patients with mild to moderate COPD less frequently met the individualized recommendations. <b><i>Conclusions:</i></b> Our study showed that applying various physical activity recommendations with small differences in frequency, intensity or time led to large differences in the classification of patients with COPD into being sufficiently physically active or not. Consequently, the used recommendation will highly affect the proposed physical activity advice to the patient.
DOI: 10.6084/m9.figshare.5126305.v1
title: Supplementary Material for: Overweight in Infancy: Which Pre- and Perinatal Factors Determine Overweight Persistence or Reduction A Birth Cohort Followed for 11 Years

description: <b><i>Background:</i></b> A considerable proportion of children with early-life overweight attain a normal weight. To recognize infants at risk of persistent overweight, we compared early-life factors of children with a longitudinal pattern of persistent overweight to children with a pattern of overweight in early but not in later childhood. <b><i>Methods:</i></b> In 3,550 children participating in a birth cohort that started in 1996/1997 in the Netherlands, body mass index was repeatedly assessed until age 11 and dichotomized into with/without overweight. Latent class growth modeling was used to distinguish trajectories. Our analysis was focused on the comparison of early-life factors in children in a persistent overweight pattern with those in an overweight reduction pattern using multivariable log-binomial regression analyses. <b><i>Results:</i></b> Children (n = 133) in the persistent overweight pattern were more likely to have overweight parents [relative risk (RR)<sub>mother</sub>: 1.85, 95% CI: 1.37-2.49: RR<sub>father</sub>: 1.75, 95% CI: 1.21-2.55] than children in the overweight reduction pattern (n = 303). Maternal education, child's gender, ethnicity, birth weight, breast-feeding and maternal smoking during pregnancy did not differ between the trajectories. <b><i>Conclusion:</i></b> Health care practitioners should focus on high-weight infants with overweight parents, as these children are less likely to resolve their overweight.
DOI: 10.6084/m9.figshare.5126308.v1
title: Supplementary Material for: Differential Associations of Dopamine-Related Polymorphisms with Discrete Components of Reaction Time Variability: Relevance for Attention Deficit/Hyperactivity Disorder

description: <b><i>Background:</i></b> Reaction time variability (RTV) is considered a valid endophenotype of attention deficit/hyperactivity disorder (ADHD). It is also often used to examine the efficacy of drug treatment or individual patients' treatment responses and has been furthermore suggested to significantly reduce the potential number of false-positive diagnoses. Among the most commonly investigated candidate genes for ADHD are DRD2, SLC6A3 (DAT), COMT and MAOA. Genetic associations have, however, proven inconclusive or inconsistent. <b><i>Methods:</i></b> Due to the complexity of dopaminergic neurotransmission in the two distinct prosencephalic dopamine pathways, we examined whether the effects of dopamine-related candidate polymorphisms in the genes DRD2, SLC6A3, COMT and MAOA may be differentially associated with discrete subcomponents of RTV, rather than global RTV. A total of 260 healthy volunteers were genotyped for the aforementioned polymorphisms and performed a reaction time paradigm able to distinguish between sensory and motor reaction time. <b><i>Results:</i></b> We found that functional polymorphisms in the genes encoding for dopamine-catabolizing enzymes (i.e. COMT and MAOA) are associated with motor RTV but not with sensory RTV, whereas vice versa the gene DRD2 influences sensory but not motor RTV. No significant associations for the gene SLC6A3 (DAT) were found. <b><i>Conclusions:</i></b> Our results give new insight into the inconsistent state of the literature regarding genetic associations of RTV and clearly show that the examination of subcomponents thereof explains far more variance compared to global RTV. This could be of great relevance to the use of RTV in basic research, clinical diagnostics and pharmacological studies examining the efficacy of novel drug treatments.
DOI: 10.6084/m9.figshare.5126293
title: Supplementary Material for: Non-Axial View of the Varicella-Zoster Virus Portal Protein Reveals Conserved Crown, Wing and Clip Architecture

description: <b><i>Background:</i></b> Herpesviridae encode a family of protein homologues that function as the ‘port of entry' for insertion of the viral DNA into preformed capsids during encapsidation. <b><i>Methods:</i></b> Transmission electron microscopy (TEM) of recombinant varicella-zoster virus pORF54 was performed. <b><i>Results:</i></b> Results suggest that pORF54 forms higher-order structures with itself. Enriched fractions analyzed by TEM revealed non-axial oriented portals with defined central channels and distinguishable crown, wing and clip regions. <b><i>Conclusion:</i></b> These morphological features are consistent with those previously reported for other herpesvirus and bacteriophage portal proteins.
DOI: 10.6084/m9.figshare.5126296
title: Supplementary Material for: Self-Medication of Psoriasis in Southwestern China

description: <b><i>Background:</i></b> Medication adherence is essential for psoriasis management. Although studies have determined the prevalence and correlative factors of non-adherence, as far as we know, there has been no study specifically addressing them in China. <b><i>Methods:</i></b> Anonymous 23-item questionnaires were distributed to 324 psoriatic patients from June 2012 to June 2013. χ<sup>2</sup> test, normality test, Student's t test or Mann-Whitney U test, Bonferroni correction and the binary logistic regression model were applied. <b><i>Results:</i></b> Self-medication of psoriasis was high in China (82.4%). Joint involvement, absence of communication with families and short communication duration with doctors were the three top factors affecting adherence. Besides low efficacy (16.0%) and recurrence frustration (27.0%), we found that patients' deception by sham advertisings (24.1%) is an non-negligible issue. <b><i>Conclusion:</i></b> Psoriasis self-medication in China was high. Improvement of patients' communication with families and/or doctors were suggested to be crucial to enhance adherence. Meanwhile, extermination of sham advertisings by administrative agencies is of great concern.
DOI: 10.6084/m9.figshare.5126299
title: Supplementary Material for: The <b><i>Drosophila</i></b> Deubiquitinating Enzyme dUSP36 Acts in the Hemocytes for Tolerance to <b><i>Listeria monocytogenes</i></b> Infections

description: <i>Listeria monocytogenes</i> is a facultative intracellular pathogen which can infect<i> Drosophila melanogaster</i>. Upon infection, <i>Drosophila</i> mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating enzyme dUSP36 in response to <i>L. monocytogenes</i> infections. We show in this report that flies with <i>dUsp36</i>-specific inactivation in hemocytes are susceptible to <i>L. monocytogenes</i> infections (as are flies with autophagy-deficient hemocytes) but are still able to control bacterial growth. Interestingly, flies with <i>dUsp36</i>-depleted hemocytes are not sensitized to infection by other pathogens. We conclude that <i>dUsp36</i> plays a major role in hemocytes for tolerance to <i>L. monocytogenes</i>.