cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3100885.v2
title: Inexact GMRES: Stokes equation

description: Figures and plotting scripts.<br>Figures 10–14 of the paper: <i>"Inexact Krylov iterations and relaxation strategies with fast-multipole boundary element method"</i><br>Submitted for peer review.<br>Fig. 10: (StokesConvergence.pdf)Convergence of the boundary-integral solution for Stokes flow around a sphere, using a first-kind equation; <i>p</i>=16, linear system solved to 10^-5 tolerance. The relative error is with respect to the analytical solution for drag on a sphere.<br>Fig. 11: (StokesResidualHistory.pdf)Residual history solving for surface traction on the surface of a sphere (first-kind integral problem), with a 10^-5 solver tolerance, 8,192 panels, and <i>p</i>=16 in the multipole expansions.<br>Fig. 12: (StokesSolveBreakdown.pdf)Time breakdown between P2P and M2L when using a relaxation strategy for solving surface traction on the surface of a sphere, 10^-5 solver tolerance, 8,192 panels, <i>p</i>=16.<br>Fig. 13: (StokesSpeedupRelaxation.pdf)Speed-up for solving first-kind Stokes equation on the surface of a sphere, varying <i>N</i>. 10^-5 solver tolerance, <i>p</i>=16.<br>Fig. 14: (StokesSpeedupTolerance.pdf)Speed-ups for solving a 1st-kind Stokes problem on a sphere discretized with 8,192 panels, as the GMRES solver's tolerance increases; <i>p</i>=16 for all cases.
DOI: 10.6084/m9.figshare.3100882.v1
title: Inexact GMRES: Laplace equation

description: Figures and plotting scripts:<br>Figures 5–9 of the paper: <i>"Inexact Krylov iterations and relaxation strategies with fast-multipole boundary element method"</i><br>Submitted for peer review.<br>Fig. 5: (LaplaceConvergence.pdf)Convergence of 1st-kind (solid line) and 2nd-kind (dotted line) solvers for the Laplace equation on a sphere, using a GMRES with FMM-accelerated matrix-vecctor products.<br>Fig. 6: (LaplaceResidualIterations.pdf)In a test using a sphere discretized with 32,768 triangles, the residual (solid line, left axis) decreases with successive GMRES iterations while the necessary <i>p</i> (open circles, right axis) to achieve convergence drops quickly.<br>Fig. 7: (LaplaceSpeedupRelaxation.pdf)Speed-up using a relaxation strategy for three different triangulations of a sphere (<i>N</i> is the number of surface panels), using 1st-kind and 2nd-kind integral formulations. (Multi-threaded evaluator running on 6 CPU cores.)<br>Fig. 8: (LaplaceRelaxationP.pdf)Timings for solving a 1st-kind Laplace integral formulation on a sphere discretized with 32,768 panels, using a relaxed GMRES with different initial values of <i>p</i>, compared with a fixed-<i>p</i> solver. The iteration count was capped at 10 for all cases. (Multi-threaded evaluator running on 6 CPU cores.)<br>Fig. 9: (LaplaceSpeedupTolerance.pdf)Speed-ups for solving a 1st-kind Laplace integral problem on a sphere discretized with 8,192 panels, as the GMRES solver's tolerance increases; <i>p</i>=10 for all cases. (Multi-threaded evaluator running on 6 CPU cores.)<br>
DOI: 10.6084/m9.figshare.3100807
title: Burden and Depression in Caregivers of Blind Patients in New York State

description: <i><b>Purpose</b></i>: To describe the degree of burden of care and the proportion at risk of depression among individuals caring for legally blind patients. <i><b>Methods</b></i>: We performed a cross-sectional study of 486 individuals providing care to their family members who were legally blind. Best-corrected visual acuity of the better-seeing eye in patients determined group placement: Group 1, 20/200–10/200; group 2, 10/200 to light perception (LP); group 3, no light perception (NLP); group VF, visual field loss to &lt;20 central degrees. Burden was evaluated using the Burden Index of Caregivers (BIC-11) and the prevalence at risk of depression was determined by the Center for Epidemiologic Studies Depression (CES-D) scale. <i><b>Results</b></i>: Total mean BIC-11 scores ranged from 8.78 ± 4.82 (group 1) to 12.03 ± 5.22 (group 3; <i>p</i> = 0.04). Daily hours spent on close supervision, intensity of caregiving and presence of multiple chronic illnesses in caregivers were the significant covariates affecting BIC-11 scores (<i>p</i> &lt; 0.05). The prevalence of caregivers at risk of depression increased with vision loss from 6.9% (group 1) to 17.9% (group 3; <i>p</i> &lt; 0.05). Female caregivers had an odds ratio (OR) of 2.89 for depression (95% confidence interval, CI, 1.07–3.97; <i>p</i> = 0.04). Caregivers with ≥2 comorbidities had OR 4.24 (95% CI 2.41–6.11) for risk of depression (<i>p</i> &lt; 0.01). <i><b>Conclusion</b></i>: Burden of care was highest among caregivers who provided greater hours of supervision. Patients with more limitations in their activities of daily living had caregivers who reported higher burden. Female caregivers and caregivers with multiple chronic illnesses were at higher risk of depression.
DOI: 10.6084/m9.figshare.3100807.v1
title: Burden and Depression in Caregivers of Blind Patients in New York State

description: <i><b>Purpose</b></i>: To describe the degree of burden of care and the proportion at risk of depression among individuals caring for legally blind patients. <i><b>Methods</b></i>: We performed a cross-sectional study of 486 individuals providing care to their family members who were legally blind. Best-corrected visual acuity of the better-seeing eye in patients determined group placement: Group 1, 20/200–10/200; group 2, 10/200 to light perception (LP); group 3, no light perception (NLP); group VF, visual field loss to &lt;20 central degrees. Burden was evaluated using the Burden Index of Caregivers (BIC-11) and the prevalence at risk of depression was determined by the Center for Epidemiologic Studies Depression (CES-D) scale. <i><b>Results</b></i>: Total mean BIC-11 scores ranged from 8.78 ± 4.82 (group 1) to 12.03 ± 5.22 (group 3; <i>p</i> = 0.04). Daily hours spent on close supervision, intensity of caregiving and presence of multiple chronic illnesses in caregivers were the significant covariates affecting BIC-11 scores (<i>p</i> &lt; 0.05). The prevalence of caregivers at risk of depression increased with vision loss from 6.9% (group 1) to 17.9% (group 3; <i>p</i> &lt; 0.05). Female caregivers had an odds ratio (OR) of 2.89 for depression (95% confidence interval, CI, 1.07–3.97; <i>p</i> = 0.04). Caregivers with ≥2 comorbidities had OR 4.24 (95% CI 2.41–6.11) for risk of depression (<i>p</i> &lt; 0.01). <i><b>Conclusion</b></i>: Burden of care was highest among caregivers who provided greater hours of supervision. Patients with more limitations in their activities of daily living had caregivers who reported higher burden. Female caregivers and caregivers with multiple chronic illnesses were at higher risk of depression.
DOI: 10.6084/m9.figshare.3100816
title: Inexact GMRES: FMM scaling

description: Figure and plotting script: Scaling of the FMM code with respect to problem size <i>N</i>, using a Laplace kernel with spherical expansions, <i>p</i>=5 and N<sub>crit</sub> = 126. The tests ran on a lab workstation using six CPU threads. The dotted line shows the expected O(N) scaling.<br>Figure 8 of the paper: <i>"Inexact Krylov iterations and relaxation strategies with fast-multipole boundary element method"</i><br>Submitted for peer review.
DOI: 10.6084/m9.figshare.3100801
title: Polysemy in the mental lexicon: relatedness and frequency affect representational overlap

description: Meaning relatedness affects storage of ambiguous words in the mental lexicon: unrelated meanings (homonymy) are stored separately whereas related senses (polysemy) are stored as one large representational entry. We hypothesised that word frequency could have similar effects on storage, with low-frequency words having high representational overlap and high-frequency words having low representational overlap. Participants performed lexical decision or semantic categorisation to high- and low-frequency nouns with few and many senses. Results showed a three-way interaction between frequency, task type, and polysemy. Low-frequency words showed a polysemy advantage with lexical decision but a polysemy disadvantage with semantic categorisation, whereas high-frequency words showed the opposite pattern. These results confirmed our hypothesis that relatedness and word frequency have similar effects on storage of ambiguous words.
DOI: 10.6084/m9.figshare.3100801.v1
title: Polysemy in the mental lexicon: relatedness and frequency affect representational overlap

description: Meaning relatedness affects storage of ambiguous words in the mental lexicon: unrelated meanings (homonymy) are stored separately whereas related senses (polysemy) are stored as one large representational entry. We hypothesised that word frequency could have similar effects on storage, with low-frequency words having high representational overlap and high-frequency words having low representational overlap. Participants performed lexical decision or semantic categorisation to high- and low-frequency nouns with few and many senses. Results showed a three-way interaction between frequency, task type, and polysemy. Low-frequency words showed a polysemy advantage with lexical decision but a polysemy disadvantage with semantic categorisation, whereas high-frequency words showed the opposite pattern. These results confirmed our hypothesis that relatedness and word frequency have similar effects on storage of ambiguous words.
DOI: 10.6084/m9.figshare.3100810
title: Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior

description: Fruit flies are important model organisms for functional testing of candidate genes in multiple disciplines, including the study of human diseases. Here we use a high-throughput locomotor activity assay to test the response on activity behavior of gene disruption in <i>Drosophila melanogaster</i>. The aim was to investigate the impact of disruption of 14 candidate genes for human attention-deficit/hyperactivity disorder (ADHD) on fly behavior. By obtaining a range of correlated measures describing the space of variables for behavioral activity we show, that some mutants display similar phenotypic responses, and furthermore, that the genes disrupted in those mutants had common molecular functions; namely processes related to cGMP activity, cation channels and serotonin receptors. All but one of the candidate genes resulted in aberrant behavioral activity, suggesting involvement of these genes in behavioral activity in fruit flies. Results provide additional support for the investigated genes being risk candidate genes for ADHD in humans.
DOI: 10.6084/m9.figshare.3100810.v2
title: Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior

description: Fruit flies are important model organisms for functional testing of candidate genes in multiple disciplines, including the study of human diseases. Here we use a high-throughput locomotor activity assay to test the response on activity behavior of gene disruption in <i>Drosophila melanogaster</i>. The aim was to investigate the impact of disruption of 14 candidate genes for human attention-deficit/hyperactivity disorder (ADHD) on fly behavior. By obtaining a range of correlated measures describing the space of variables for behavioral activity we show, that some mutants display similar phenotypic responses, and furthermore, that the genes disrupted in those mutants had common molecular functions; namely processes related to cGMP activity, cation channels and serotonin receptors. All but one of the candidate genes resulted in aberrant behavioral activity, suggesting involvement of these genes in behavioral activity in fruit flies. Results provide additional support for the investigated genes being risk candidate genes for ADHD in humans.
DOI: 10.6084/m9.figshare.3100816.v1
title: Inexact GMRES: FMM scaling

description: Figure and plotting script: Scaling of the FMM code with respect to problem size <i>N</i>, using a Laplace kernel with spherical expansions, <i>p</i>=5 and N<sub>crit</sub> = 126. The tests ran on a lab workstation using six CPU threads. The dotted line shows the expected O(N) scaling.<br>Figure 8 of the paper: <i>"Inexact Krylov iterations and relaxation strategies with fast-multipole boundary element method"</i><br>Submitted for peer review.
DOI: 10.6084/m9.figshare.3100681
title: Hart et al., HNE paper

description: These are all of the files related to the Hart et al. paper on HNE and children's math skills
DOI: 10.6084/m9.figshare.3100765
title: Protocols and ICs

description: NLP of ICs and protocols to enable protocol modeling for research decision support
DOI: 10.6084/m9.figshare.3100810.v1
title: A high-throughput assay for complex activity behaviors in <i>Drosophila</i>

description: Fruit flies are important model organisms in functional testing of candidate genes in multiple disciplines, including the study of human diseases. Precise and well-defined phenotypes are a necessity in this respect. Here we propose a high-throughput locomotor activity assay for <i>Drosophila melanogaster</i> and decompose this trait into several distinct sub-traits. Insertional gene disruption mutants were used to investigate the impact of disruption of fourteen candidate genes for human attention-deficit/hyperactivity disorder (ADHD) on fly behavior. We demonstrated that obtaining a range of measures describing the space of variables for behavioral activity, some mutants display similar phenotypic responses, and furthermore, that the genes that were disrupted in those lines had shared molecular functions. All but one of the candidate genes resulted in aberrant behavioral activity, suggesting involvement of these genes in behavioral activity in flies, providing additional support for the genes being risk candidate genes for ADHD.
DOI: 10.6084/m9.figshare.3100660
title: Effects of aging and sensory modality on navigation in a virtual maze

description: The "pat" folder contains the raw data collected from all participants. The "drawings" folder contains the scanned drawings from all participants.
DOI: 10.6084/m9.figshare.3100657
title: shp.n2eu28.RData.zip

description: This RData file contains 3 shapefiles ready to be read in R. <br><br>The shapefiles (R objects) are:<br>Sborders - SpatialLinesDataFrame - borders between EU28 countries.<br>Sn2 - SpatialPolygonsDataFrame - NUTS-2 regions of EU28 countries (NUTS 2010 version).<br>Sneighbors - SpatialPolygons - background layer with neighboring countries.<br><br>All shapefiles are projected in EPSG:3035 (ETRS89 / ETRS-LAEA).<br><br>
DOI: 10.6084/m9.figshare.3100681.v1
title: Hart et al., HNE paper

description: These are all of the files related to the Hart et al. paper on HNE and children's math skills
DOI: 10.6084/m9.figshare.3100630
title: Supplemental NMR Data for PONE-D-15-52129R1

description: Sample preparation, NMR spectra, and NMR binned data to support manuscript, PONE-D-15-52129R1, "Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function."
DOI: 10.6084/m9.figshare.3100765.v2
title: Protocols and ICs

description: NLP of ICs and protocols to enable protocol modeling for research decision support
DOI: 10.6084/m9.figshare.3100630.v1
title: Supplemental NMR Data for PONE-D-15-52129R1

description: Sample preparation, NMR spectra, and NMR binned data to support manuscript, PONE-D-15-52129R1, "Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function."
DOI: 10.6084/m9.figshare.3100765.v1
title: Protocols and ICs

description: NLP of ICs and protocols to enable protocol modeling for research decision support
DOI: 10.6084/m9.figshare.3100657.v2
title: shp.n2eu28.RData.zip

description: This RData file contains 3 shapefiles ready to be read in R. <br><br>The shapefiles (R objects) are:<br>Sborders - SpatialLinesDataFrame - borders between EU28 countries.<br>Sn2 - SpatialPolygonsDataFrame - NUTS-2 regions of EU28 countries (NUTS 2010 version).<br>Sneighbors - SpatialPolygons - background layer with neighboring countries.<br><br>All shapefiles are projected in EPSG:3035 (ETRS89 / ETRS-LAEA).<br><br>
DOI: 10.6084/m9.figshare.3100660.v1
title: subject raw data and drawings

description: The "pat" folder contains the raw data collected from all participants. The "drawings" folder contains the scanned drawings from all participants.
DOI: 10.6084/m9.figshare.3100549
title: Mechanics of Presynaptic Transmission

description: <br> A group of phosphotungstic acid based fixatives demonstrated chains of synaptic vesicles in the presynaptic bulb of the motor endplates of the rat diaphragm and produced precipitates in those vesicles. PTA fixatives containing trichloroacetic acid resulted in precipitate in the neurotubules. An hypothesis was offered that the neurotubules were like sausage casings manufactured in the body of the nerve, filled with bound Ach and pushed down the axon by accretion until they reached the membrane wall of the synaptic bulb. The environment of the synaptic bulb is such that the tubule walls are weakened and surface tension forces pinch off vesicles. There is a competition between the breakdown of tubules and their advancement to the presynaptic membrane such that not only vesicles are excytosed but on rare occasions also tubules. This results in the resting stage mini-potentials described by Fatt and Katz. A second form of transmitter release is non-exocytotic. In this case inflow of calcium ions through the axon wall as a result of the AP reversal of the membrane potential cause an osmotic bursting of those vesicles in the vicinity of the flow with expulsion of transmitter which can be seen as streaks running from the interior of burst, now horseshoe-shaped vesicles, which flow across the inter-membrane space and enter into the muscle. Fig. 263 Barrage An attempt is made to unify the various observations into a comprehensive theory of the mechanics of presynaptic transmission.
DOI: 10.6084/m9.figshare.3100573
title: The role of diseases, risk factors and symptoms in the definition of multimorbidity – a systematic review

description: Objective is to explore how multimorbidity is defined in the scientific literature, with a focus on the roles of diseases, risk factors, and symptoms in the definitions. Design: Systematic review. Methods: MEDLINE (PubMed), Embase, and The Cochrane Library were searched for relevant publications up until October 2013. One author extracted the information. Ambiguities were resolved, and consensus reached with one co-author. Outcome measures were: cut-off point for the number of conditions included in the definitions of multimorbidity; setting; data sources; number, kind, duration, and severity of diagnoses, risk factors, and symptoms. We reviewed 163 articles. In 61 articles (37%), the cut-off point for multimorbidity was two or more conditions (diseases, risk factors, or symptoms). The most frequently used setting was the general population (68 articles, 42%), and primary care (41 articles, 25%). Sources of data were primarily self-reports (56 articles, 42%). Out of the 163 articles selected, 115 had individually constructed multimorbidity definitions, and in these articles diseases occurred in all definitions, with diabetes as the most frequent. Risk factors occurred in 98 (85%) and symptoms in 71 (62%) of the definitions. The severity of conditions was used in 26 (23%) of the definitions, but in different ways. The definition of multimorbidity is heterogeneous and risk factors are more often included than symptoms. The severity of conditions is seldom included. Since the number of people living with multimorbidity is increasing there is a need to develop a concept of multimorbidity that is more useful in daily clinical work. Key PointsThe increasing number of multimorbidity patients challenges the healthcare system. The concept of multimorbidity needs further discussion in order to be implemented in daily clinical practice.Many definitions of multimorbidity exist and most often a cut-off point of two or more is applied to a range of 4–147 different conditions.Diseases are included in all definitions of multimorbidity.Risk factors are often included in existing definitions, whereas symptoms and the severity of the conditions are less frequently included. The increasing number of multimorbidity patients challenges the healthcare system. The concept of multimorbidity needs further discussion in order to be implemented in daily clinical practice. Many definitions of multimorbidity exist and most often a cut-off point of two or more is applied to a range of 4–147 different conditions. Diseases are included in all definitions of multimorbidity. Risk factors are often included in existing definitions, whereas symptoms and the severity of the conditions are less frequently included.
DOI: 10.6084/m9.figshare.3100573.v1
title: The role of diseases, risk factors and symptoms in the definition of multimorbidity – a systematic review

description: Objective is to explore how multimorbidity is defined in the scientific literature, with a focus on the roles of diseases, risk factors, and symptoms in the definitions. Design: Systematic review. Methods: MEDLINE (PubMed), Embase, and The Cochrane Library were searched for relevant publications up until October 2013. One author extracted the information. Ambiguities were resolved, and consensus reached with one co-author. Outcome measures were: cut-off point for the number of conditions included in the definitions of multimorbidity; setting; data sources; number, kind, duration, and severity of diagnoses, risk factors, and symptoms. We reviewed 163 articles. In 61 articles (37%), the cut-off point for multimorbidity was two or more conditions (diseases, risk factors, or symptoms). The most frequently used setting was the general population (68 articles, 42%), and primary care (41 articles, 25%). Sources of data were primarily self-reports (56 articles, 42%). Out of the 163 articles selected, 115 had individually constructed multimorbidity definitions, and in these articles diseases occurred in all definitions, with diabetes as the most frequent. Risk factors occurred in 98 (85%) and symptoms in 71 (62%) of the definitions. The severity of conditions was used in 26 (23%) of the definitions, but in different ways. The definition of multimorbidity is heterogeneous and risk factors are more often included than symptoms. The severity of conditions is seldom included. Since the number of people living with multimorbidity is increasing there is a need to develop a concept of multimorbidity that is more useful in daily clinical work. Key PointsThe increasing number of multimorbidity patients challenges the healthcare system. The concept of multimorbidity needs further discussion in order to be implemented in daily clinical practice.Many definitions of multimorbidity exist and most often a cut-off point of two or more is applied to a range of 4–147 different conditions.Diseases are included in all definitions of multimorbidity.Risk factors are often included in existing definitions, whereas symptoms and the severity of the conditions are less frequently included. The increasing number of multimorbidity patients challenges the healthcare system. The concept of multimorbidity needs further discussion in order to be implemented in daily clinical practice. Many definitions of multimorbidity exist and most often a cut-off point of two or more is applied to a range of 4–147 different conditions. Diseases are included in all definitions of multimorbidity. Risk factors are often included in existing definitions, whereas symptoms and the severity of the conditions are less frequently included.