cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10026476
title: ASSOCIATION OF MMP-7 -181A&gt;G POLYMORPHISM WITH COLORECTAL CANCER AND GASTRIC CANCER SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS

description: ABSTRACT Introduction: The matrix metalloproteinase-7 (MMP-7) gene -181A&gt;G polymorphism has been reported to be associated with colorectal cancer (CRC) and gastric cancer (GC) susceptibility, yet the results of these previous results have been inconsistent or controversial. Aim: To elaborate a meta-analysis to assess the association of -181A&gt;G polymorphism of MMP-7 with CRC and GC risk. Methods: Published literature evaluating the association from PubMed, Web of Science, Google Scholar and other databases were retrieved up to April 25, 2018. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model. Results: A total of 19 case-control studies, which included eleven studies on CRC (2,169 CRC cases and 2,346 controls) and eight studies on GC (1,545 GC cases and 2,366 controls) were identified. There was a significant association between MMP-7 -181A&gt;G polymorphism and GC risk under the homozygote model (GG vs. AA: OR=1.672, 95% CI 1.161-2.409, p=0.006) and the recessive model (GG vs. GA+AA: OR=1.672, 95% CI 1.319-2.554, p=0.001), but not with CRC. By subgroup analysis based on ethnicity, an increased risk of CRC and GC was found only among Asians. Conclusions: This meta-analysis suggests that MMP-7 -181A&gt;G polymorphisms is associated with GC risk, but not with CRC. However, our results clearly showed that the MMP-7 -181A&gt;G polymorphism significantly increased the risk of CRC only in Asians.
DOI: 10.6084/m9.figshare.10026482.v1
title: ASSOCIATION OF RS2435357 AND RS1800858 POLYMORPHISMS IN RET PROTO-ONCOGENE WITH HIRSCHSPRUNG DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS

description: ABSTRACT Introduction: Many published studies have estimated the association of rs2435357 and rs1800858 polymorphisms in the proto-oncogene rearranged during transfection (RET) gene with Hirschsprung disease (HSCR) risk. However, the results remain inconsistent and controversial. Aim: To perform a meta-analysis get a more accurate estimation of the association of rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene with HSCR risk. Methods: The eligible literatures were searched by PubMed, Google Scholar, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) up to June 30, 2018. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to HSCR. Results: A total of 20 studies, including ten (1,136 cases 2,420 controls) for rs2435357 and ten (917 cases 1,159 controls) for rs1800858 were included. The overall results indicated that the rs2435357 (allele model: OR=0.230, 95% CI 0.178-0.298, p=0.001; homozygote model: OR=0.079, 95% CI 0.048-0.130, p=0.001; heterozygote model: OR=0.149, 95% CI 0.048-0.130, p=0.001; dominant model: OR=0.132, 95% CI 0.098-0.179, p=0.001; and recessive model: OR=0.239, 95% CI 0.161-0.353, p=0.001) and rs1800858 (allele model: OR=5.594, 95% CI 3.653-8.877, p=0.001; homozygote model: OR=8.453, 95% CI 3.783-18.890, p=0.001; dominant model: OR=3.469, 95% CI 1.881-6.396, p=0.001; and recessive model: OR=6.120, 95% CI 3.608-10.381, p=0.001) polymorphisms were associated with the increased risk of HSCR in overall. Conclusions: The results suggest that the rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene might be associated with HSCR risk.
DOI: 10.6084/m9.figshare.10026467
title: A New Cytotoxic Naphthoquinone and Other Chemical Constituents of Sinningia reitzii

description: Phytochemical study of Sinningia reitzii (Gesneriaceae) led to the isolation of three new naphtoquinones, 6,7-dimethoxydunnione, 7-hydroxy-6-methoxydunnione, and 5-hydroxy-6,7-dimethoxydunnione from the tubers, together with four known compounds, 7-hydroxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione, and 8-hydroxydeydrodunnione. Aerial parts furnished five known compounds, 5-hydroxy-6,7-dimethoxydunniol, 6,8-dihydroxy-7-methoxy-2-O-methyldunniol, loureirin B, jacaranone, and methyl 4-hydroxyphenylacetate. Compounds 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione, 8-hydroxydeydrodunnione, 5-hydroxy-6,7-dimethoxydunniol and 6,8-dihydroxy-7-methoxy-2-O-methyldunniol had been previously reported in the tubers of S. reitzii. Density functional theory was used to assign the absolute configuration of compounds 6,7-dimethoxydunnione, 7-hydroxy-6-methoxydunnione 5-hydroxy-6,7-dimethoxydunnione, 7-hydroxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione. Compounds 6,7-dimethoxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione and 8-hydroxydeydrodunnione were evaluated for cytotoxicity against PC3 (prostate), SKMEL 103 (melanoma), and HeLa (cervix) human cancer, and 3T3 fibroblast cell lines, using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Compound 6,7-dimethoxydunnione displays cytotoxic activity against all the tumor cell lines tested (half maximal inhibitory concentration, IC50, 4.47-26.2 µmol L-1), and was inactive against 3T3 fibroblasts (IC50 &gt; 100 µmol L-1). Compounds 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione and 8-hydroxydeydrodunnione were inactive against all tested cell lines.
DOI: 10.6084/m9.figshare.10026476.v1
title: ASSOCIATION OF MMP-7 -181A&gt;G POLYMORPHISM WITH COLORECTAL CANCER AND GASTRIC CANCER SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS

description: ABSTRACT Introduction: The matrix metalloproteinase-7 (MMP-7) gene -181A&gt;G polymorphism has been reported to be associated with colorectal cancer (CRC) and gastric cancer (GC) susceptibility, yet the results of these previous results have been inconsistent or controversial. Aim: To elaborate a meta-analysis to assess the association of -181A&gt;G polymorphism of MMP-7 with CRC and GC risk. Methods: Published literature evaluating the association from PubMed, Web of Science, Google Scholar and other databases were retrieved up to April 25, 2018. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model. Results: A total of 19 case-control studies, which included eleven studies on CRC (2,169 CRC cases and 2,346 controls) and eight studies on GC (1,545 GC cases and 2,366 controls) were identified. There was a significant association between MMP-7 -181A&gt;G polymorphism and GC risk under the homozygote model (GG vs. AA: OR=1.672, 95% CI 1.161-2.409, p=0.006) and the recessive model (GG vs. GA+AA: OR=1.672, 95% CI 1.319-2.554, p=0.001), but not with CRC. By subgroup analysis based on ethnicity, an increased risk of CRC and GC was found only among Asians. Conclusions: This meta-analysis suggests that MMP-7 -181A&gt;G polymorphisms is associated with GC risk, but not with CRC. However, our results clearly showed that the MMP-7 -181A&gt;G polymorphism significantly increased the risk of CRC only in Asians.
DOI: 10.7910/dvn/52wspt/amjthu
title: CRAIGSLIST.CT.zip

description: This is a census tract-level shapefile that contains neighborhood ecometrics generated from Craigslist postings in a spatial format.
DOI: 10.6084/m9.figshare.10026464
title: Common mental disorders and resilience in homeless persons

description: ABSTRACT Objective: To identify common mental disorders and resilience in homeless persons. Method: Cross-sectional study with 49 homeless persons, assisted in the Casa da Acolhida Adulta and the Specialized Reference Center in a municipality in the Northeast of Brazil. Data collection performed between February and March 2018, using SRQ20 scales for common mental disorders and another for Resilience. Kruskal Wallis test, Student’s T-test and Chi-Square test were used. Results: In the study, 61.2% (30) participants have poor sleep; 69.4% (34) feel nervous, tense or worried; 71.4% (35) feel unhappy; 63.3% are unable to play a useful role in their lives; 71.4% (35) have common mental disorders, and 44.9% (22) presented low resilience. Resilience influences common mental disorders, which, in turn, are influenced by gender and age. Conclusion: Professionals who assist homeless persons need to have a look directed at common mental disorders and resilience.
DOI: 10.6084/m9.figshare.10026467.v1
title: A New Cytotoxic Naphthoquinone and Other Chemical Constituents of Sinningia reitzii

description: Phytochemical study of Sinningia reitzii (Gesneriaceae) led to the isolation of three new naphtoquinones, 6,7-dimethoxydunnione, 7-hydroxy-6-methoxydunnione, and 5-hydroxy-6,7-dimethoxydunnione from the tubers, together with four known compounds, 7-hydroxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione, and 8-hydroxydeydrodunnione. Aerial parts furnished five known compounds, 5-hydroxy-6,7-dimethoxydunniol, 6,8-dihydroxy-7-methoxy-2-O-methyldunniol, loureirin B, jacaranone, and methyl 4-hydroxyphenylacetate. Compounds 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione, 8-hydroxydeydrodunnione, 5-hydroxy-6,7-dimethoxydunniol and 6,8-dihydroxy-7-methoxy-2-O-methyldunniol had been previously reported in the tubers of S. reitzii. Density functional theory was used to assign the absolute configuration of compounds 6,7-dimethoxydunnione, 7-hydroxy-6-methoxydunnione 5-hydroxy-6,7-dimethoxydunnione, 7-hydroxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione. Compounds 6,7-dimethoxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione and 8-hydroxydeydrodunnione were evaluated for cytotoxicity against PC3 (prostate), SKMEL 103 (melanoma), and HeLa (cervix) human cancer, and 3T3 fibroblast cell lines, using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Compound 6,7-dimethoxydunnione displays cytotoxic activity against all the tumor cell lines tested (half maximal inhibitory concentration, IC50, 4.47-26.2 µmol L-1), and was inactive against 3T3 fibroblasts (IC50 &gt; 100 µmol L-1). Compounds 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy-α-dunnione and 8-hydroxydeydrodunnione were inactive against all tested cell lines.
DOI: 10.6084/m9.figshare.10026464.v1
title: Common mental disorders and resilience in homeless persons

description: ABSTRACT Objective: To identify common mental disorders and resilience in homeless persons. Method: Cross-sectional study with 49 homeless persons, assisted in the Casa da Acolhida Adulta and the Specialized Reference Center in a municipality in the Northeast of Brazil. Data collection performed between February and March 2018, using SRQ20 scales for common mental disorders and another for Resilience. Kruskal Wallis test, Student’s T-test and Chi-Square test were used. Results: In the study, 61.2% (30) participants have poor sleep; 69.4% (34) feel nervous, tense or worried; 71.4% (35) feel unhappy; 63.3% are unable to play a useful role in their lives; 71.4% (35) have common mental disorders, and 44.9% (22) presented low resilience. Resilience influences common mental disorders, which, in turn, are influenced by gender and age. Conclusion: Professionals who assist homeless persons need to have a look directed at common mental disorders and resilience.
DOI: 10.6084/m9.figshare.10026452
title: Motor skills of children with autism spectrum disorder

description: Abstract The objective of this study is to describe variables of life habits associated with motor skills of children with autism spectrum disorder aged 8-10 years living in the city of Pelotas / RS. A questionnaire about lifestyle was applied and the Test of Gross Motor Development-2 (TGMD-2) was applied to assess motor skills. Independent T-test, ANOVA and Wilcoxon test were used to compare means. The study consisted of 49 individuals (42 males). The results indicate that the higher the level of ASD, the better the motor skills. Children making use of medications have greater deficits in motor skills. Higher scores on motor skills are associated with greater participation in physical education classes. Motor skills are strongly associated with independence in activities of the daily living, food, personal hygiene, dressing and bathing. The importance of the creation of PA programs aiming at improving the motor skills of this population was highlighted.
DOI: 10.6084/m9.figshare.10026455
title: Changes in developmental assets across a 4-month competitive season among youth basketball players

description: Abstract The present study examined the changes in developmental assets among young basketball players during a 4-month competitive period, accounting for variation by age group. Additionally, we examined the age-related variation on developmental assets. Sixty-five adolescent basketball players aged between 9.5 to 17.3 years were considered. We used the Portuguese version of the Developmental Assets Profile Questionnaire. Multilevel modeling was used to estimate the magnitude of changes on developmental assets across the 4-month competitive season, as well as aligning assets scores by chronological age. Positive values and positive identity scores were substantially increased after the 4-month competitive sample. The other assets scores showed no variation across the competitive 4-month competitive season, independent of age group. There was a trend of linear decrease in developmental assets as the adolescent players got older. For positive values, there was a non-linear trend with a higher decrease rate between about 10 to 14 years, levelling off thereafter. Developmental assets did not appear to be influenced by exposure to a period of organized training and competition among adolescent basketball players. Hence, the observed decrease on developmental assets when aligning by age may reflect the influence of contextual and cultural environments of practice. This is of particularly interest for positive values, which refer to school engagement or and social justice, qualities that are not sport-specific but assume a key and importance position in sport participation for a positive role in youth development.
DOI: 10.6084/m9.figshare.10026449
title: Power and agility testing within the NBA pre-draft combine

description: Abstract Considering agility is a prerequisite for basketball performance and several agility tests have been used during the pre-draft assessment of the National Basketball Association (NBA), the aimed of this study was to examine the associations between pre-draft athletes´ performance scores in NBA draft combine testing protocol. The performance of 480 athletes invited to the NBA pre-draft assessment from 2010 to 2017 was considered. Tests in the NBA Draft Combine considered in this study included the Shuttle Run Test, Lane Agility Test, Sprint Test, and Jump Test (standing vertical leap). Zero order correlations were calculated to examine the associations between performance tests by fitting Bayesian linear regression models. Among running testing, both Shuttle Run Test [r=0.45, 95% confidence interval (CI) 0.34 to 0.56) and Sprint Test (r=0.45, 95% CI 0.37 to 0.54) were moderately associated with the Lane Agility Test. The association between the Sprint Test and Shuttle Run Test was moderate at best (r=0.27, 95% CI 0.16 to 0.38). Correlations between Jump Test and running tests were moderate to large, ranging from -0.51 to -0.19 (Lane Agility Test: r=-0.33, 95% CI -0.42 to -0.24; Shuttle Run Test: r=-0.19, 95% CI -0.31 to -0.07; Sprint Test: r=-0.51, 95% CI -0.59 to -0.43). As a conclusion, we found a moderate to large correlations between the tests performance of the NBA Draft Combine, implying that the overall procedures may provide in part overlapping information about basketball maximal short term performance.
DOI: 10.6084/m9.figshare.10026452.v1
title: Motor skills of children with autism spectrum disorder

description: Abstract The objective of this study is to describe variables of life habits associated with motor skills of children with autism spectrum disorder aged 8-10 years living in the city of Pelotas / RS. A questionnaire about lifestyle was applied and the Test of Gross Motor Development-2 (TGMD-2) was applied to assess motor skills. Independent T-test, ANOVA and Wilcoxon test were used to compare means. The study consisted of 49 individuals (42 males). The results indicate that the higher the level of ASD, the better the motor skills. Children making use of medications have greater deficits in motor skills. Higher scores on motor skills are associated with greater participation in physical education classes. Motor skills are strongly associated with independence in activities of the daily living, food, personal hygiene, dressing and bathing. The importance of the creation of PA programs aiming at improving the motor skills of this population was highlighted.
DOI: 10.6084/m9.figshare.10026455.v1
title: Changes in developmental assets across a 4-month competitive season among youth basketball players

description: Abstract The present study examined the changes in developmental assets among young basketball players during a 4-month competitive period, accounting for variation by age group. Additionally, we examined the age-related variation on developmental assets. Sixty-five adolescent basketball players aged between 9.5 to 17.3 years were considered. We used the Portuguese version of the Developmental Assets Profile Questionnaire. Multilevel modeling was used to estimate the magnitude of changes on developmental assets across the 4-month competitive season, as well as aligning assets scores by chronological age. Positive values and positive identity scores were substantially increased after the 4-month competitive sample. The other assets scores showed no variation across the competitive 4-month competitive season, independent of age group. There was a trend of linear decrease in developmental assets as the adolescent players got older. For positive values, there was a non-linear trend with a higher decrease rate between about 10 to 14 years, levelling off thereafter. Developmental assets did not appear to be influenced by exposure to a period of organized training and competition among adolescent basketball players. Hence, the observed decrease on developmental assets when aligning by age may reflect the influence of contextual and cultural environments of practice. This is of particularly interest for positive values, which refer to school engagement or and social justice, qualities that are not sport-specific but assume a key and importance position in sport participation for a positive role in youth development.
DOI: 10.6084/m9.figshare.10026437
title: Social support, self-efficacy and level of physical activity of students aged 13-15 years

description: Abstract The aim of this study was to verify the relationship, the population attributable fraction (PAF) and the relative risk reduction (RRR) of social support and self-efficacy with level of physical activity in students. Probabilistic cross-sectional study with 1,472 students aged 13-15 years. Gender, age, social support from parents and friends, self-efficacy and levels of physical activity were evaluated through questionnaires. Data analysis was performed using Poisson regression with robust variance, PAF and RRR, adopting p≤0.05. A total of 56.1% (n = 826) of students were considered active, boys (68.7%) presenting the largest proportion. Social support from parents was positively associated with physical activity in boys (PR: 1.28, 95% CI: 1.12-1.48, PAF = 21.88) and girls (PR: 2.00; 95%CI: 1.59-2.51, PAF = 50.00). Social support from friends was positively associated with physical activity in boys (PR: 1.34, 95%CI: 1.16-1.54, PAF = 25.37) and girls (PR: 1.32, 95%CI: 1.06-1.64, PAF = 24.24). Self-efficacy was not associated with physical activity. Social support was associated with levels of physical activity, and PAF indicated that the absence of high social support from parents and friends might reduce the level of physical activity in adolescents.
DOI: 10.6084/m9.figshare.10026440
title: Oxygen consumption and heart rate obtained in a ramp protocol are equivalent during exercise session of rectangular loading at ventilatory thresholds for athletes

description: Abstract Training near or at ventilatory threshold (VT) is an adequate stimulus to improve the thresholds for sedentary subjects, but a higher intensity is necessary for conditioned subjects. The choice of cardiopulmonary exercise testing (CPx) protocol has an influence on VTs identification and can reduce their reliability for exercise prescription. This study tested if VO2 and heart rate (HR) corresponding to first (VT1) and second ventilatory threshold (VT2) determined during a ramp protocol were equivalent to those observed in rectangular load exercises at the same intensity in runners elite athletes (EA) and non-athletes (NA). Eighteen health subjects were divided into two groups: EA (n = 9, VO2max 68.6 mL·kg-1·min-1) and NA (n = 9, VO2max 47.2 mL·kg-1·min-1). They performed CPx and 48h and 96h later, a continuous running lasting 1 h for VT1 and until exhaustion for VT2. The results showed that EA at VT1 session, presented delta differences for VO2 (+9.1%, p = 0.125) vs. NA (+20.5%, p = 0.012). The Bland-Altman plots for VT1 presented biases of (4.4 ± 6.9) and (5.5 ± 5.6 mLO2·kg-1·min-1) for AE and NA, respectively. In VT2, the VO2 and HR of the NA showed biases of (0.4 ± 2.9 mLO2·kg-1·min-1) and (4.9 ± 4.2 bpm). The ramp protocol used in this study was inappropriate for NA because it underestimates the values of VO2 and HR at VT1 found in the rectangular load exercise. The HR showed good agreement at VT2 with CPx and may be a good parameter for controlling exercise intensity.
DOI: 10.6084/m9.figshare.10026443
title: Comparison of maturation and physical performance in basketball athletes of different playing positions

description: Abstract The aim of this study was to compare the characteristics of somatic maturation, anthropometric and physical performance (vertical jump and aerobic power) in young basketball players of different playing positions (under 13 years) and analyze these relationships using Peak Height Velocity (PHV) as a measure of somatic maturation. For this, 26 male athletes were evaluated. Anthropometric variables were: body mass, standing and sitting height, and length of lower limbs. Maturation was determined by age at PHV. Physical performance was determined by lower limb power (counter movement jump - CMJ) and aerobic power (Intermittent Recovery Test) tests. MANOVA reported significant differences (p&lt;0.05) among playing positions regarding variables Maturity Offset, estimated PHV age, standing height, sitting height, estimated leg length, body mass and Yo-Yo IR1. In addition, it was identified that point guards reached estimated PHV at later age than their peers who act as small forwards and centers. Regarding CMJ, no significant differences were identified among playing positions, but in relation to aerobic power, point guards and small forwards presented higher performance. These findings confirm that maturation has great effect on growth and physical performance measures and the estimated PHV age is an applicable tool in young athletes, mainly aiding professionals in structuring the teaching-learning- training process in this age group.