cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4249160
title: Monitoring safety and use of old and new treatment options for type 2 diabetic patients: a two-year (2013–2016) analysis

description: <b>Objective</b>: To compare patients’ and physicians’ perceptions regarding effectiveness and tolerability of non-insulin hypoglycemic drugs in a cohort of type 2 diabetic patients; to verify whether a possible tridimensional link between effectiveness, tolerability, and adherence affects long-term therapeutic outcomes. <b>Methods</b>: A two-year observational study was performed in 1389 Type 2 diabetic patients by involving general practitioner clinics and Diabetes Centers. A decimal scale and the Morisky questionnaire were used, respectively, to assess effectiveness and tolerability perceptions, and medication adherence. <b>Results</b>: Physicians perceived therapy as more efficacious compared to their patients: perceived effectiveness was steady for physicians during the study whereas patients’ perception not significantly decreased (mean score from &gt;8 to 7.84 ± 1.69). Physicians assigned higher tolerability scores compared to patients but only at the beginning of the study; interestingly, physicians’ tolerability perception was poorer than patients’ perception at last follow-up (mean score = 7.57 ± 1.40 vs. 7.88 ± 1.84). Favorable (score &gt;7) patients’ perceptions about treatment effectiveness and tolerability were associated with higher adherence. Patients showed medium adherence across the study. <b>Conclusions</b>: A mutual relationship between clinical effectiveness, adverse drug reactions, and adherence has been established, significantly impacting the clinical management of diabetic patients. A careful monitoring of this link by clinicians appears therefore necessary.
DOI: 10.6084/m9.figshare.4249160.v1
title: Monitoring safety and use of old and new treatment options for type 2 diabetic patients: a two-year (2013–2016) analysis

description: <b>Objective</b>: To compare patients’ and physicians’ perceptions regarding effectiveness and tolerability of non-insulin hypoglycemic drugs in a cohort of type 2 diabetic patients; to verify whether a possible tridimensional link between effectiveness, tolerability, and adherence affects long-term therapeutic outcomes. <b>Methods</b>: A two-year observational study was performed in 1389 Type 2 diabetic patients by involving general practitioner clinics and Diabetes Centers. A decimal scale and the Morisky questionnaire were used, respectively, to assess effectiveness and tolerability perceptions, and medication adherence. <b>Results</b>: Physicians perceived therapy as more efficacious compared to their patients: perceived effectiveness was steady for physicians during the study whereas patients’ perception not significantly decreased (mean score from &gt;8 to 7.84 ± 1.69). Physicians assigned higher tolerability scores compared to patients but only at the beginning of the study; interestingly, physicians’ tolerability perception was poorer than patients’ perception at last follow-up (mean score = 7.57 ± 1.40 vs. 7.88 ± 1.84). Favorable (score &gt;7) patients’ perceptions about treatment effectiveness and tolerability were associated with higher adherence. Patients showed medium adherence across the study. <b>Conclusions</b>: A mutual relationship between clinical effectiveness, adverse drug reactions, and adherence has been established, significantly impacting the clinical management of diabetic patients. A careful monitoring of this link by clinicians appears therefore necessary.
DOI: 10.6084/m9.figshare.4249148
title: Raw Data in Spanish PERCEPTION OF AIR AND WATER POLLUTION AND ITS ASSOCIATION WITH RISK CANCER PERCEPTION IN A REGION WITH HIGH CANCER MORTALITY IN MEXICO

description: Raw data of a survey applied in Cuatro Cienegas and La Madrid Municipalities are presented. The survey assess the perception of air and water pollution and also risk perception of develop cancer.
DOI: 10.21227/g21e-7473
title: Dataset with cyber attacks in HoneySELK

description: Due to the large number of vulnerabilities in information systems and the continuous activity of attackers, techniques for malicious traffic detection are required to identify and protect against cyber-attacks. Therefore, it is important to intentionally operate a cyber environment to be invaded and compromised in order to allow security professionals to analyze the evolution of the various attacks and exploited vulnerabilities.This dataset includes 2016, 2017 and 2018 cyber attacks in the HoneySELK environment.HoneySELK was developed to control, capture, analyze and visualize new and unknown attacks in real time within the research laboratory of the Electrical Engineering Department of the University of Brasília. - Rodrigues, G.A.P.; Albuquerque, R.d.O.; de Deus, F.E.G.; de Sousa, R.T., Jr.; de Oliveira Júnior, G.A. Cybersecurity and Network Forensics: Analysis of Malicious Traffic towards a Honeynet with Deep Packet Inspection. Appl. Sci. 2017, 7, 1082 (https://www.mdpi.com/2076-3417/7/10/1082).- Oliveira Júnior, G.A.; de Sousa, R.T., Jr.; de Albuquerque, R.O.; Canedo, E.D.; Grégio, A. HoneySELK: Um Ambiente para Pesquisa e Visualização de Ataques Cibernéticos em Tempo Real. In Proceedings of the XVI Simpósio Brasileiro em Segurança da Informação e de Sistemas Computacionais, Niteroi, Rio de Janeiro, Brazil, 7–10 November 2016; pp. 697–706 (http://sbseg2016.ic.uff.br/pt/anais.php and https://repositorio.unb.br/handle/10482/22886).- Oliveira Jr, G. A., Sousa Jr, R. T. de, Tenório, D. F. (2015). Desenvolvimento de um Ambiente Honeynet Virtual para Aplicação Governamental. In: The Ninth International Conference on Forensic Computer Science. v. 1. p. 70-80 (http://www.icofcs.org/2015/papers-published-009.html).
DOI: 10.6084/m9.figshare.4248962
title: Macroalgae macromolecular database

description: A compilation of data from published literature of the macromolecular content (protein, lipid, carbohydrate) of macroalgae.<br>Accompanies paper by Fiset et al (2017) in Limnology & Oceanography: Methods. doi: 10.1002/lom3.10186.<br>
DOI: 10.6084/m9.figshare.4248917
title: database of 104 species of the Algerian steppe.xlsx

description: We present here probably the first functional database of feature for the steppe of North Africa (Algeria) of 104 species in terms of underground vegetative features and surface, features floral and flowering period. In this region, the strong seasonality in abiotic harshness and pollinators’ availability shape the reproductive success of plants and the right moment of flowering is essential for reproductive success. However, it is still poorly understood which traits constrain the timing (phenology) of flowering in a given, harsh environments. We hypothesized that phenological differentiation may be controlled by the plants’ tolerance or avoidance of drought stress and the plants’ capacity of attracting particular groups of pollinators (reflected, respectively, by vegetative and floral traits). We also present the novel hypothesis that a plant’s tolerance to drought might either relax or strengthen the effect of pollinator groups on phenology. This permits to show that flowering phenology is strongly influenced by the plants’ ability to tolerate drought through deep roots (but not leaf traits), and the plant’s ability to attract different pollinators through different floral colours and shapes. Most interestingly, root depth modified the effects of floral characters. In the more tolerant, deep-rooting species flowering phenologies converge among species attracting different pollinators (without becoming less variable overall). Abiotically less tolerant species, in contrast, appear to suffer a double burden from water stress and limited pollinator availability. Global warming might reinforce this double abiotic and biotic burden.<br>
DOI: 10.6084/m9.figshare.4248911
title: 11-20-TeamCompositionxlsx.xlsx

description: <br>This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for constructing a team of experts.
DOI: 10.6084/m9.figshare.4248917.v1
title: database of 104 species of the Algerian steppe.xlsx

description: We present here probably the first functional database of feature for the steppe of North Africa (Algeria) of 104 species in terms of underground vegetative features and surface, features floral and flowering period. In this region, the strong seasonality in abiotic harshness and pollinators’ availability shape the reproductive success of plants and the right moment of flowering is essential for reproductive success. However, it is still poorly understood which traits constrain the timing (phenology) of flowering in a given, harsh environments. We hypothesized that phenological differentiation may be controlled by the plants’ tolerance or avoidance of drought stress and the plants’ capacity of attracting particular groups of pollinators (reflected, respectively, by vegetative and floral traits). We also present the novel hypothesis that a plant’s tolerance to drought might either relax or strengthen the effect of pollinator groups on phenology. This permits to show that flowering phenology is strongly influenced by the plants’ ability to tolerate drought through deep roots (but not leaf traits), and the plant’s ability to attract different pollinators through different floral colours and shapes. Most interestingly, root depth modified the effects of floral characters. In the more tolerant, deep-rooting species flowering phenologies converge among species attracting different pollinators (without becoming less variable overall). Abiotically less tolerant species, in contrast, appear to suffer a double burden from water stress and limited pollinator availability. Global warming might reinforce this double abiotic and biotic burden.<br>
DOI: 10.6084/m9.figshare.4248911.v1
title: 11-20-TeamCompositionxlsx.xlsx

description: <br>This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for constructing a team of experts.
DOI: 10.6084/m9.figshare.4248908
title: 11-20-ProjectDataCollectionxlsx.xlsx

description: <br>This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". This file contains multiple tables for the collection of personal expert data and physical process data.
DOI: 10.6084/m9.figshare.4248908.v1
title: 11-20-ProjectDataCollectionxlsx.xlsx

description: <br>This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". This file contains multiple tables for the collection of personal expert data and physical process data.
DOI: 10.6084/m9.figshare.4248899
title: 11-20-ExpertWeightRankingxlsx.xlsx

description: <br>This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for data and opinion collection from a team of experts.It provides algorithms for assigning weights to experts.<br>
DOI: 10.6084/m9.figshare.4248899.v1
title: 11-20-ExpertWeightRankingxlsx.xlsx

description: <br>This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for data and opinion collection from a team of experts.It provides algorithms for assigning weights to experts.<br>
DOI: 10.6084/m9.figshare.4248884.v1
title: 11-20-DeltaTempxlsx.xlsx

description: This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for data and opinion collection from a team of experts.
DOI: 10.6084/m9.figshare.4248884.v3
title: 11-20-DeltaTempxlsx.xlsx

description: This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for data and opinion collection from a team of experts.
DOI: 10.6084/m9.figshare.4248884.v2
title: 11-20-DeltaTempxlsx.xlsx

description: This file is an Excel 2010 companion and support file to a research manuscript entitled "Computational methodology for quantifying regional and global temperature changes caused by multiple concurrent processes". It contains multiple tables for data and opinion collection from a team of experts.
DOI: 10.6084/m9.figshare.4248839
title: Confocal z-stacks of Figure S3

description: Z-stacks of invading MDA-MB-231 at 0,3,5 and 10 days were obtained using confocal microscope.<br>
DOI: 10.6084/m9.figshare.4248839.v2
title: Confocal z-stacks of Figure S3

description: Z-stacks of invading MDA-MB-231 at 0,3,5 and 10 days were obtained using confocal microscope.<br>
DOI: 10.6084/m9.figshare.4248833
title: Individual values attributed to forests in Amazonia

description: Data set of the values atrributed to the forest (material and non-material) for the enterviewees in the study. <br><br>This data set was used to:<br><br>1. calculate the association between independent variables (hunting, consumption and control variables) and the material value of forests (using forest_value_all_hh_heads table). <br><br>2. calculate the association between independent variables (forest cover, visits to forest and control variables) and the non-material value of forests (using forest_value_heads_that_visit_forest table).<br><br>3. Scale evaluation (using forest values statments table). <br>
DOI: 10.6084/m9.figshare.4248839.v1
title: Confocal z-stacks of figure S3

description: Z-stacks of invading MDA-MB-231 at 0,3,5 and 10 days were obtained using confocal microscope.<br>
DOI: 10.6084/m9.figshare.4248833.v1
title: Individual values attributed to forests

description: Data set of the values atrributed to the forest (material and non-material) for the enterviewees in the study. <br><br>This data set was used to:<br><br>1. calculate the association between independent variables (hunting, consumption and control variables) and the material value of forests (using forest_value_all_hh_heads table). <br><br>2. calculate the association between independent variables (forest cover, visits to forest and control variables) and the non-material value of forests (using forest_value_heads_that_visit_forest table).<br><br>3. Scale evaluation (using forest values statments table). <br>
DOI: 10.6084/m9.figshare.4248824
title: Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes

description: The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12–ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. The ATG16L1 complex dissociates from the phagophore before autophagosome membrane closure. Thus, ATG16L1 can be used as an early event marker for the study of autophagosome biogenesis. We found that among 3 proteins in the ATG16L1 complex, only ATG16L1 formed puncta-like structures when transiently overexpressed. ATG16L1<sup>+</sup> puncta formed by transient expression could represent autophagic membrane structures. We thoroughly characterized the transiently expressed ATG16L1 in several mammalian cell lines. We found that transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates. We conclude that transient expression of ATG16L1 is not a physiological model for the study of autophagy. Caution is warranted when reviewing findings derived from a transient expression model of ATG16L1.
DOI: 10.6084/m9.figshare.4248824.v2
title: Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes

description: The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12–ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. The ATG16L1 complex dissociates from the phagophore before autophagosome membrane closure. Thus, ATG16L1 can be used as an early event marker for the study of autophagosome biogenesis. We found that among 3 proteins in the ATG16L1 complex, only ATG16L1 formed puncta-like structures when transiently overexpressed. ATG16L1<sup>+</sup> puncta formed by transient expression could represent autophagic membrane structures. We thoroughly characterized the transiently expressed ATG16L1 in several mammalian cell lines. We found that transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates. We conclude that transient expression of ATG16L1 is not a physiological model for the study of autophagy. Caution is warranted when reviewing findings derived from a transient expression model of ATG16L1.
DOI: 10.6084/m9.figshare.4248818
title: HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in <i>C. elegans</i>

description: Autophagy is an evolutionarily conserved intracellular system that maintains cellular homeostasis by degrading and recycling damaged cellular components. The transcription factor HLH-30/TFEB-mediated autophagy has been reported to regulate tolerance to bacterial infection, but less is known about the <i>bona fide</i> bacterial effector that activates HLH-30 and autophagy. Here, we reveal that bacterial membrane pore-forming toxin (PFT) induces autophagy in an HLH-30-dependent manner in <i>Caenorhabditis elegans</i>. Moreover, autophagy controls the susceptibility of animals to PFT toxicity through xenophagic degradation of PFT and repair of membrane-pore cell-autonomously in the PFT-targeted intestinal cells in <i>C. elegans</i>. These results demonstrate that autophagic pathways and autophagy are induced partly at the transcriptional level through HLH-30 activation and are required to protect metazoan upon PFT intoxication. Together, our data show a new and powerful connection between HLH-30-mediated autophagy and epithelium intrinsic cellular defense against the single most common mode of bacterial attack in vivo.
DOI: 10.6084/m9.figshare.4248824.v1
title: Transiently Expressed ATG16L1 Inhibits Autophagosome Biogenesis and Aberrantly Targets RAB11-positive Recycling Endosomes

description: The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12-ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. The ATG16L1 complex dissociates from the phagophore before autophagosome membrane closure. Thus, ATG16L1 can be used as an early event marker for the study of autophagosome biogenesis. We found that among 3 proteins in the ATG16L1 complex, only ATG16L1 formed puncta-like structures when transiently overexpressed. ATG16L1<sup>+</sup> puncta formed by transient expression could represent autophagic membrane structures. We thoroughly characterized the transiently expressed ATG16L1 in several mammalian cell lines. We found that transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates. We conclude that transient expression of ATG16L1 is not a physiological model for the study of autophagy. Caution is warranted when reviewing findings derived from a transient expression model of ATG16L1.
DOI: 10.6084/m9.figshare.4248818.v1
title: HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in <i>C. elegans</i>

description: Autophagy is an evolutionarily conserved intracellular system that maintains cellular homeostasis by degrading and recycling damaged cellular components. The transcription factor HLH-30/TFEB-mediated autophagy has been reported to regulate tolerance to bacterial infection, but less is known about the <i>bona fide</i> bacterial effector that activates HLH-30 and autophagy. Here, we reveal that bacterial membrane pore-forming toxin (PFT) induces autophagy in an HLH-30-dependent manner in <i>Caenorhabditis elegans</i>. Moreover, autophagy controls the susceptibility of animals to PFT toxicity through xenophagic degradation of PFT and repair of membrane-pore cell-autonomously in the PFT-targeted intestinal cells in <i>C. elegans</i>. These results demonstrate that autophagic pathways and autophagy are induced partly at the transcriptional level through HLH-30 activation and are required to protect metazoan upon PFT intoxication. Together, our data show a new and powerful connection between HLH-30-mediated autophagy and epithelium intrinsic cellular defense against the single most common mode of bacterial attack in vivo.
DOI: 10.6084/m9.figshare.4248767
title: Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase

description: Spns1 (Spinster homolog 1 [<i>Drosophila</i>]) in vertebrates, as well as Spin (Spinster) in <i>Drosophila</i>, is a hypothetical lysosomal H<sup>+</sup>-carbohydrate transporter, which functions at a late stage of macroautophagy (hereafter autophagy). The Spin/Spns1 defect induces aberrant autolysosome formation that leads to developmental senescence in the embryonic stage and premature aging symptoms in adulthood. However, the molecular mechanism by which loss of Spin/Spns1 leads to the specific pathogenesis remains to be elucidated. Using chemical, genetic and CRISPR/Cas9-mediated genome-editing approaches in zebrafish, we investigated and determined a mechanism that suppresses embryonic senescence as well as autolysosomal impairment mediated by Spns1 deficiency. Unexpectedly, we found that a concurrent disruption of the vacuolar-type H<sup>+</sup>-ATPase (v-ATPase) subunit gene, <i>atp6v0ca</i> (ATPase, H<sup>+</sup> transporting, lysosomal, V0 subunit ca) led to suppression of the senescence induced by the Spns1 defect, whereas the sole loss of Atp6v0ca led to senescent embryos similar to the single <i>spns1</i> mutation. Moreover, we discovered that the combined stable defect seen in the presence of both the <i>spns1</i> and <i>atp6v0ca</i> mutant genes still subsequently induced premature autophagosome-lysosome fusion marked by insufficient acidity, while extending developmental life span, compared with the solely mutated <i>spns1</i> defect. Our data suggest that Spns1 and the v-ATPase orchestrate proper autolysosomal biogenesis with optimal acidification that is critically linked to developmental senescence and survival.