cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.3144910
title: An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma

description: Although consumption of chrysotile asbestos has decreased since the 1970s, the latency period of asbestos-related cancers is thought to be at least 20–30 years, and therefore the potential health risks associated with historical exposures is still actively researched. This analysis represents an update to a previous paper in which we evaluated the exposure–response relationships for lung cancer and mesothelioma in chrysotile-exposed cohorts. Here, we review several recently published studies as well as updated information from previous studies. For each of the 14 studies considered, we identified the “no-observed adverse effect level” (NOAEL) for lung cancer and/or mesothelioma. NOAEL values for lung cancer ranged from 1.1 to &lt;20 f/cc-years to 1600–3200 f/cc-years, and for mesothelioma ranged from 100–400 f/cc-years to 800–1599 f/cc-years. The range of “best estimate” NOAELs was estimated to be 89–168 f/cc-years for lung cancer and 208–415 f/cc-years for mesothelioma. None of the six cohorts of cement or friction product manufacturing workers exhibited an increased lung cancer risk at any exposure level, while all of the five studies of textile workers reported an increased risk at one or more exposure levels. This is likely because friction and cement workers were exposed to much shorter chrysotile fibers. Of the seven cases of peritoneal mesothelioma reported in the included studies, none were observed in the analyses of cement or friction product manufacturing workers in the absence of crocidolite exposure. These findings will help characterize potential worker and consumer health risks associated with historical and current chrysotile exposures.
DOI: 10.6084/m9.figshare.3144910.v1
title: An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma

description: Although consumption of chrysotile asbestos has decreased since the 1970s, the latency period of asbestos-related cancers is thought to be at least 20–30 years, and therefore the potential health risks associated with historical exposures is still actively researched. This analysis represents an update to a previous paper in which we evaluated the exposure–response relationships for lung cancer and mesothelioma in chrysotile-exposed cohorts. Here, we review several recently published studies as well as updated information from previous studies. For each of the 14 studies considered, we identified the “no-observed adverse effect level” (NOAEL) for lung cancer and/or mesothelioma. NOAEL values for lung cancer ranged from 1.1 to &lt;20 f/cc-years to 1600–3200 f/cc-years, and for mesothelioma ranged from 100–400 f/cc-years to 800–1599 f/cc-years. The range of “best estimate” NOAELs was estimated to be 89–168 f/cc-years for lung cancer and 208–415 f/cc-years for mesothelioma. None of the six cohorts of cement or friction product manufacturing workers exhibited an increased lung cancer risk at any exposure level, while all of the five studies of textile workers reported an increased risk at one or more exposure levels. This is likely because friction and cement workers were exposed to much shorter chrysotile fibers. Of the seven cases of peritoneal mesothelioma reported in the included studies, none were observed in the analyses of cement or friction product manufacturing workers in the absence of crocidolite exposure. These findings will help characterize potential worker and consumer health risks associated with historical and current chrysotile exposures.
DOI: 10.6084/m9.figshare.3144895.v1
title: VIOLA Input Questionnaires v1.0

description: This questionnaire aims at capturing how many people talk to an infant during a typical week (short and long forms), as well as capturing stability (is one person always present) and local variability (how many different people are present at a time, how big is the change during a typical day; long forms only). Available languages: FrenchEnglish
DOI: 10.6084/m9.figshare.3144838
title: Data file for "Investigating the role of assessment method on reports of déjà vu and tip-of-the-tongue states during standard recognition tests"

description: Data file for:<br> Jersakova, R., Moulin, C.J.A. & O’Connor, A.R. <strong> </strong>(accepted 2016). Investigating the role of assessment method on reports of déjà vu and tip-of-the-tongue states during standard recognition tests. <em>PLoS ONE. </em>doi:10.1371/journal.pone.0154334
DOI: 10.6084/m9.figshare.3144859
title: No place for /h/: an ERP investigation of English fricative place features

description: The representational format of speech units in long-term memory is a topic of debate. We present novel event-related brain potential evidence from the Mismatch Negativity (MMN) paradigm that is compatible with abstract, non-redundant feature-based models like the Featurally Underspecified Lexicon (FUL). First, we show that the fricatives /s/ and /f/ display an asymmetric pattern of MMN responses, which is predicted if /f/ has a fully specified place of articulation ([Labial]) but /s/ does not ([Coronal], which is lexically underspecified). Second, we show that when /s/ and /h/ are contrasted, no such asymmetric MMN pattern occurs. The lack of asymmetry suggests both that (i) oral and laryngeal articulators are represented distinctly and that (ii) /h/ has no oral place of articulation in long-term memory. The lack of asymmetry between /s/ and /h/ is also in-line with traditional feature-geometric models of lexical representations.
DOI: 10.6084/m9.figshare.3144859.v1
title: No place for /h/: an ERP investigation of English fricative place features

description: The representational format of speech units in long-term memory is a topic of debate. We present novel event-related brain potential evidence from the Mismatch Negativity (MMN) paradigm that is compatible with abstract, non-redundant feature-based models like the Featurally Underspecified Lexicon (FUL). First, we show that the fricatives /s/ and /f/ display an asymmetric pattern of MMN responses, which is predicted if /f/ has a fully specified place of articulation ([Labial]) but /s/ does not ([Coronal], which is lexically underspecified). Second, we show that when /s/ and /h/ are contrasted, no such asymmetric MMN pattern occurs. The lack of asymmetry suggests both that (i) oral and laryngeal articulators are represented distinctly and that (ii) /h/ has no oral place of articulation in long-term memory. The lack of asymmetry between /s/ and /h/ is also in-line with traditional feature-geometric models of lexical representations.
DOI: 10.6084/m9.figshare.3144775
title: ICV and number of years occupied by the colony of CO

description: This file contains data concerning ICV and number of years occupied by the colony of centenarian oaks (CO).
DOI: 10.6084/m9.figshare.3144841.v1
title: Mortality analysis of an urban building stock

description: Research is presented on the estimation of the lifespan of cohorts of buildings and building stocks. This is based on the analysis of extensive longitudinal data of the 55 000 buildings in the City of Zurich from 1832 and 2010. The survival probability from different perspectives considers age, construction periods, and demolition periods for both existing and demolished buildings. Survival probability is established using a Kaplan–Meier estimator. A more in-depth approach to the mortality of buildings is then determined by differentiating building age, use, size and geographical situation (district). The use of a common geographical information system (GIS) allows longitudinal building data to be linked to a geographical hierarchy of three levels of analysis (city, district and building) accounting for the different granularity on each level (neighbourhoods, quarters, building parts). A comparison of the two methods indicates that the choice of the observed time periods can lead to very different results. The analysis of the three levels shows the possibilities and limits of combined statistical and historical approaches. Mortality analysis is a promising approach to inform policy and practice; it could become a new link between long-term scenario planning, construction policies and institutional regimes.
DOI: 10.6084/m9.figshare.3144724
title: NCO ICV x # of nests

description: This file contains data concerning ICV of non centenarian oaks as well as the overall number of nests they hosted.
DOI: 10.6084/m9.figshare.3144727
title: norovirus_outbreak_kinmen_taiwan_2015.xlsx

description: This dataset includes 363 individuals from a norovirus outbreak in Kinmen, Taiwan
DOI: 10.6084/m9.figshare.3144733
title: NCO ICV x # years occupied by the colony

description: This file contains data concerning ICV and total number of years occupied by the colony of non centenarian oaks
DOI: 10.6084/m9.figshare.3144661
title: Serbian National Health Survey Database

description: These data are part of the 2013 National Health Survey for the population of Serbia (without data on Kosovo and Metohia), which was carried out by the Ministry of Health of the Republic of Serbia The survey was conducted in accordance with the methodology and instruments of the European Health Interview Survey wave 2 (EHIS-wave 2). Data on demographic and socio-economic characteristics of the respondents and their own health assessment was obtained through a face-to-face interview carried out at home, while information at the level of the household was obtained by means of a household questionnaire. The questions were validated instruments based on the standard questionnaires from similar types of surveys.
DOI: 10.6084/m9.figshare.3144724.v1
title: NCO ICV x # of nests

description: This file contains data concerning ICV of non centenarian oaks as well as the overall number of nests they hosted.
DOI: 10.6084/m9.figshare.3144733.v1
title: NCO ICV x # years occupied by the colony

description: This file contains data concerning ICV and total number of years occupied by the colony of non centenarian oaks
DOI: 10.6084/m9.figshare.3144661.v1
title: Serbian National Health Survey Database

description: These data are part of the 2013 National Health Survey for the population of Serbia (without data on Kosovo and Metohia), which was carried out by the Ministry of Health of the Republic of Serbia The survey was conducted in accordance with the methodology and instruments of the European Health Interview Survey wave 2 (EHIS-wave 2). Data on demographic and socio-economic characteristics of the respondents and their own health assessment was obtained through a face-to-face interview carried out at home, while information at the level of the household was obtained by means of a household questionnaire. The questions were validated instruments based on the standard questionnaires from similar types of surveys.
DOI: 10.6084/m9.figshare.3144727.v1
title: dataset1.xlsx

description: This dataset includes 363 individuals from a norovirus outbreak in Kinmen, Taiwan
DOI: 10.6084/m9.figshare.3144556
title: Large-scale analysis of auditory segregation behavior crowdsourced via a smartphone app

description: The file contains the raw data from the 'How well do you hear' game featured in the Great Brain Experiment app. Any personal identifiers have been removed and sharing of the data is approved by the UCL Ethics panel.
DOI: 10.6084/m9.figshare.3144508
title: Rhythmic modulation of visual contrast discrimination triggered by action

description: Recent evidence suggests that ongoing brain oscillations may be instrumental in binding and integrating multisensory signals. In the present experiment, we investigated the temporal dynamics of visual-motor integration processes. We show that action modulates sensitivity to visual contrast discrimination in a rhythmic fashion at frequencies of about 5Hz (in the theta range), for up to one second after execution of action. To understand the origin of the oscillations, we measured oscillations in contrast sensitivity at different levels of luminance, which is known to affect the endogenous brain rhythms, boosting the power of alpha-frequencies. We found that the frequency of oscillation in sensitivity increased at low-luminance, likely reflecting the shift in mean endogenous brain rhythm towards higher frequencies. Importantly, both at high and at low luminance, contrast discrimination showed a rhythmic motor-induced suppression effect, with the suppression occurring earlier at low luminance. We suggest that oscillations play a key role in sensory-motor integration, and that the motor-induced suppression may reflect the first manifestation of a rhythmic oscillation.
DOI: 10.6084/m9.figshare.3144553
title: The PLETHORA gene regulatory network guides growth and cell differentiation in Arabidopsis roots

description: This is the code used in the study by Santuari et al., 2016, The Plant Cell.Please refer to the Supplemental Data for additional details about the data and the methods used.
DOI: 10.6084/m9.figshare.3144556.v2
title: Large-scale analysis of auditory segregation behavior crowdsourced via a smartphone app

description: The file contains the raw data from the 'How well do you hear' game featured in the Great Brain Experiment app. Any personal identifiers have been removed and sharing of the data is approved by the UCL Ethics panel.
DOI: 10.6084/m9.figshare.3144727.v4
title: norovirus_outbreak_kinmen_taiwan_2015.xlsx

description: This dataset includes 363 individuals from a norovirus outbreak in Kinmen, Taiwan
DOI: 10.6084/m9.figshare.3144556.v1
title: PLoSOne_Tekietal_SFG_app_raw_data.xlsx

description: The file contains the raw data from the 'How well do you hear' game featured in the Great Brain Experiment app. Any personal identifiers have been removed and sharing these data is approved by the UCL Ethics panel.
DOI: 10.6084/m9.figshare.3144727.v3
title: norovirus_outbreak_kinmen_taiwan_2015.xlsx

description: This dataset includes 363 individuals from a norovirus outbreak in Kinmen, Taiwan
DOI: 10.6084/m9.figshare.3144505.v1
title: 17 October 2014 Field Notes

description: Field notes including image and/or video records.
DOI: 10.6084/m9.figshare.3144508.v1
title: Rhythmic modulation of visual contrast discrimination triggered by action

description: Recent evidence suggests that ongoing brain oscillations may be instrumental in binding and integrating multisensory signals. In the present experiment, we investigated the temporal dynamics of visual-motor integration processes. We show that action modulates sensitivity to visual contrast discrimination in a rhythmic fashion at frequencies of about 5Hz (in the theta range), for up to one second after execution of action. To understand the origin of the oscillations, we measured oscillations in contrast sensitivity at different levels of luminance, which is known to affect the endogenous brain rhythms, boosting the power of alpha-frequencies. We found that the frequency of oscillation in sensitivity increased at low-luminance, likely reflecting the shift in mean endogenous brain rhythm towards higher frequencies. Importantly, both at high and at low luminance, contrast discrimination showed a rhythmic motor-induced suppression effect, with the suppression occurring earlier at low luminance. We suggest that oscillations play a key role in sensory-motor integration, and that the motor-induced suppression may reflect the first manifestation of a rhythmic oscillation.
DOI: 10.6084/m9.figshare.3144505.v2
title: 17 October 2014 Field Notes

description: Field notes including image and/or video records.
DOI: 10.6084/m9.figshare.3144508.v2
title: Rhythmic modulation of visual contrast discrimination triggered by action

description: Recent evidence suggests that ongoing brain oscillations may be instrumental in binding and integrating multisensory signals. In the present experiment, we investigated the temporal dynamics of visual-motor integration processes. We show that action modulates sensitivity to visual contrast discrimination in a rhythmic fashion at frequencies of about 5Hz (in the theta range), for up to one second after execution of action. To understand the origin of the oscillations, we measured oscillations in contrast sensitivity at different levels of luminance, which is known to affect the endogenous brain rhythms, boosting the power of alpha-frequencies. We found that the frequency of oscillation in sensitivity increased at low-luminance, likely reflecting the shift in mean endogenous brain rhythm towards higher frequencies. Importantly, both at high and at low luminance, contrast discrimination showed a rhythmic motor-induced suppression effect, with the suppression occurring earlier at low luminance. We suggest that oscillations play a key role in sensory-motor integration, and that the motor-induced suppression may reflect the first manifestation of a rhythmic oscillation.
DOI: 10.6084/m9.figshare.3144502.v1
title: 26 September 2014 Field Notes

description: Field notes including image and/or video records.
DOI: 10.6084/m9.figshare.3142423
title: Pig Heart Data

description: The data set includes 41 MR image short-axis slices of a pig heart in-vivo. Six raters labeled the left and right ventricles as well as the two RV insertion points, yielding 246 labeled images. The cine MR data and labeled images are published.
DOI: 10.6084/m9.figshare.3142417
title: Ovine rumen papillae biopsy via oral endoscopy; a rapid and repeatable method for serial sampling

description: AIMS: To explore and validate the utility of rumen endoscopy for collection of rumen papillae for gene expression measurement. METHODS: Four adult Coopworth ewes were fasted for either 4 or 24 hours. Animals were sedated, placed in a dorsally recumbent position at 45 degrees with the head upright, and an endoscope inserted via a tube inserted into the mouth. Biopsies of rumen papillae were taken from the ventral surface of the rumen atrium under visual guidance. Two biopsies were collected from one of the animals that had been fasted for 4 hours, and three from one of the animals that had been fasted for 24 hours. Video of the rumen atrium and reticulum was also collected. The animals recovered uneventfully. Biopsies were subsequently used for extraction and sequencing of mRNA. RESULTS: The ventral surface of the rumen atrium was accessible after 4 hours off pasture, but a larger region was accessible after 24 hours of fasting. Sedation allowed access for endoscope use for around 5 to 10 minutes after which increased saliva flow was noted. Rumen papillae biopsies were easily collected, with samples from a variety of sites collected in the ∼10 minute time window. High quality RNA was obtained for stranded mRNA sequencing. Of the resulting reads, 69–70% mapped uniquely to version 3.1 of the ovine genome, and 48–49% to a known gene. The rumen mRNA profiles were consistent with a previously reported study. CONCLUSIONS: This method for obtaining rumenal tissue was found to be rapid and resulted in no apparent short or long term effects on the animal. High quality RNA was successfully extracted and amplified from the rumen papillae biopsies, indicating that this technique could be used for future gene expression studies. The use of rumen endoscopy could be extended to collection of a variety of rumen and reticulum anatomical measurements and deposition and retrieval of small sensors from the rumen. Rumen endoscopy offers an attractive and cost effective approach to repeated rumen biopsies compared with serial slaughter or use of cannulated animals.
DOI: 10.6084/m9.figshare.3144502.v2
title: 26 September 2014 Field Notes

description: Field notes including image and/or video records.
DOI: 10.6084/m9.figshare.3142411
title: Putative digenic inheritance of heterozygous <i>RP1L1</i> and <i>C2orf71</i> null mutations in syndromic retinal dystrophy

description: <i>Background</i>: Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration and can occur in non-syndromic and syndromic forms. Syndromic RP is accompanied by other symptoms such as intellectual disability, hearing loss, or congenital abnormalities. Both forms are known to exhibit complex genetic interactions that can modulate the penetrance and expressivity of the phenotype. <i>Materials and methods</i>: In an individual with atypical RP, hearing loss, ataxia and cerebellar atrophy, whole exome sequencing was performed. The candidate pathogenic variants were tested by developing an <i>in vivo</i> zebrafish model and assaying for retinal and cerebellar integrity. <i>Results</i>: Exome sequencing revealed a complex heterozygous protein-truncating mutation in <i>RP1L1</i>, p.[(Lys111Glnfs*27; Gln2373*)], and a heterozygous nonsense mutation in <i>C2orf71</i>, p.(Ser512*). Mutations in both genes have previously been implicated in autosomal recessive non-syndromic RP, raising the possibility of a digenic model in this family. Functional testing in a zebrafish model for two key phenotypes of the affected person showed that the combinatorial suppression of <i>rp1l1</i> and <i>c2orf71l</i> induced discrete pathology in terms of reduction of eye size with concomitant loss of rhodopsin in the photoreceptors, and disorganization of the cerebellum. <i>Conclusions</i>: We propose that the combination of heterozygous loss-of-function mutations in these genes drives syndromic retinal dystrophy, likely through the genetic interaction of at least two loci. Haploinsufficiency at each of these loci is insufficient to induce overt pathology.
DOI: 10.6084/m9.figshare.3142411.v1
title: Putative digenic inheritance of heterozygous <i>RP1L1</i> and <i>C2orf71</i> null mutations in syndromic retinal dystrophy

description: <i>Background</i>: Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration and can occur in non-syndromic and syndromic forms. Syndromic RP is accompanied by other symptoms such as intellectual disability, hearing loss, or congenital abnormalities. Both forms are known to exhibit complex genetic interactions that can modulate the penetrance and expressivity of the phenotype. <i>Materials and methods</i>: In an individual with atypical RP, hearing loss, ataxia and cerebellar atrophy, whole exome sequencing was performed. The candidate pathogenic variants were tested by developing an <i>in vivo</i> zebrafish model and assaying for retinal and cerebellar integrity. <i>Results</i>: Exome sequencing revealed a complex heterozygous protein-truncating mutation in <i>RP1L1</i>, p.[(Lys111Glnfs*27; Gln2373*)], and a heterozygous nonsense mutation in <i>C2orf71</i>, p.(Ser512*). Mutations in both genes have previously been implicated in autosomal recessive non-syndromic RP, raising the possibility of a digenic model in this family. Functional testing in a zebrafish model for two key phenotypes of the affected person showed that the combinatorial suppression of <i>rp1l1</i> and <i>c2orf71l</i> induced discrete pathology in terms of reduction of eye size with concomitant loss of rhodopsin in the photoreceptors, and disorganization of the cerebellum. <i>Conclusions</i>: We propose that the combination of heterozygous loss-of-function mutations in these genes drives syndromic retinal dystrophy, likely through the genetic interaction of at least two loci. Haploinsufficiency at each of these loci is insufficient to induce overt pathology.