cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/m4hhfk3tw7.2
title: Senescence of endplate osteoclasts induces sensory innervation and spinal pain

description: Spinal pain affects individuals of all ages and is the most common musculoskeletal problem globally. Its clinical management remains a challenge as the underlying mechanisms leading to it are still unclear. Here, we report that greater numbers of senescent osteoclasts (SnOCs) are observed in mouse models of spinal hypersensitivity, like lumbar spine instability (LSI) or aging, compared to controls. The larger population of SnOCs is associated with induced sensory nerve innervation, as well as the growth of H-type vessels, in the porous endplate. We show that deletion of senescent cells by administration of the senolytic drug Navitoclax (ABT263) results in significantly less spinal hypersensitivity, spinal degeneration, porosity of the endplate, sensory nerve innervation and H-type vessel growth in the endplate. We also show that there is greater SnOC-mediated secretion of Netrin-1 and NGF, two well-established sensory nerve growth factors, compared to non-senescent OCs. These findings suggest that pharmacological elimination of SnOCs may be a potent therapy to treat spinal pain.
DOI: 10.17632/k3ryss65p5.1
title: Breatihg sound digital stethoscope educational course

description: the students get breathing sound course
DOI: 10.17632/mvwr8mjz3k.2
title: Effects of ultrasound stimuli on mechanical and biological properties of ligament fibroblasts

description: Research hypothesis: Ultrasound stimulation on ligament fibroblasts will increase their elastic modulus, harmonic vibration, cell proliferation, migration, synthesis of extracellular matrix (ECM) (Collagen type I, type III and Fibronectin), and β-actin expression.

Data shows the elastic modulus (Pa); Harmonic of the natural frequency of vibration (Hz); cell proliferation (Cell number/mL) on 2nd, 4th, and 6th day of culture; cell migration length (um); synthesis of proteins: collagen type I (ng/mL), type III (ng/mL) and Fibronectin (ng/mL); β-actin area (cm2) for treated cells and the control group.

Following ultrasound stimulation (at either 1.0 W/cm2 (Group A-low dose) or 2.0 W/cm2 (Group B-high dose) for five days every 24 hours, Control cells (Group C) were manipulated identically with ultrasound off) the elastic modulus of ligament fibroblasts decreased (Group A, 22%; Group B, 31%) (p<0.05). The harmonic of the natural frequency of vibration of ligament fibroblasts decreased (Group A, 13%; Group B, 17%). Cell proliferation and migration increased by 10% and 4%, (Group A), and decreased by 13% and 11%, (Group B) (p<0.05). Synthesis of type I collagen was increased 100% following the high dose, but no type III collagen synthesis was detected in cells stimulated for the low dose or in control cells. Fibronectin production was significantly increased following ultrasound stimulation (79%, Group A; 61%, Group B). Most cells were viable (85%, Group A; 77%, Group B; 86%, Group C). The low dose of ultrasound decreased the β-actin area by 74%, and the high dose decreased the β-actin area by 31%.
DOI: 10.17632/mvwr8mjz3k.3
title: Effects of ultrasound stimuli on mechanical and biological properties of ligament fibroblasts

description: Research hypothesis: Ultrasound stimulation on ligament fibroblasts will increase their elastic modulus, harmonic vibration, cell proliferation, migration, synthesis of extracellular matrix (ECM) (Collagen type I, type III and Fibronectin), and β-actin expression.

Data shows the elastic modulus (Pa); Harmonic of the natural frequency of vibration (Hz); cell proliferation (Cell number/mL) on 2nd, 4th, and 6th day of culture; cell migration length (um); synthesis of proteins: collagen type I (ng/mL), type III (ng/mL) and Fibronectin (ng/mL); β-actin area (cm2) for treated cells and the control group.

Following ultrasound stimulation (at either 1.0 W/cm2 (Group A-low dose) or 2.0 W/cm2 (Group B-high dose) for five days every 24 hours, Control cells (Group C) were manipulated identically with ultrasound off) the elastic modulus of ligament fibroblasts decreased (Group A, 22%; Group B, 31%) (p&lt;0.05). The harmonic of the natural frequency of vibration of ligament fibroblasts decreased (Group A, 13%; Group B, 17%). Cell proliferation and migration increased by 10% and 4%, (Group A), and decreased by 13% and 11%, (Group B) (p&lt;0.05). Synthesis of type I collagen was increased 100% following the high dose, but no type III collagen synthesis was detected in cells stimulated for the low dose or in control cells. Fibronectin production was significantly increased following ultrasound stimulation (79%, Group A; 61%, Group B). Most cells were viable (85%, Group A; 77%, Group B; 86%, Group C). The low dose of ultrasound decreased the β-actin area by 74%, and the high dose decreased the β-actin area by 31%.
DOI: 10.17632/4v65czhnrj.1
title: Municipal FOI Requests - Chile 2020

description: Dataset for the article: "Understanding Freedom of Information Requests: Predictors of Request for Public Information to Municipalities in Chile", by Hernández-Bonivento, J. & Moller, F.
DOI: 10.15468/dl.ccsku8
title: Occurrence Download

description: A dataset containing 453 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lathyrus amphicarpos L."
 ]
}

 The dataset includes 453 records from 70 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000132-250117103327516/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/t4hf26kkyh.1
title: Did the American Rescue Plan Cause Inflation?: A Synthetic Control Approach

description: Replication Folder for "Did the American Rescue Plan Cause Inflation?: A Synthetic Control Approach" by Dong Gyun Ko
DOI: 10.17632/brzyhyxs9g.1
title: LINF_360055200

description: UTP18
Leishmania infantum (strain JPCM5)
DOI: 10.34740/kaggle/dsv/10496872
title: Daily Public Opinion on Israel-Palestine War
DOI: 10.6084/m9.figshare.27291183
title: Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing

description: Skin flaps are employed to cover cutaneous denuded surfaces, but ensuing flap necrosis often occurs. Previously, rats with myocardial infarction treated with lipid-core nanoparticles (LDE) loaded with methotrexate (MTX) improved myocardial irrigation and reduced necrosis. Here, the aim was to investigate the efficacy of LDE-MTX to preserve the viability of cutaneous flaps and its implications for surgical wound healing. Twenty-eight male rats were divided into 4 groups: (1) LDE, injected intraperitoneally with LDE only; (2) MTX (1 mg/Kg commercial MTX): (3) LDE-MTX (1 mg/Kg MTX associated with LDE), and controls without treatment. LDE, MTX or LDE-MTX were repeated after 2 days. Then, flap surgery (9x3cm) was performed on the dorsal region. Injections were continued every other day until day 7 when animals were euthanized. LDE-MTX treatment improved the total viable area of the flaps with a fourfold increase in blood flow and reduced inflammatory cell number (<i>p</i> &lt; 0.001), accompanied by decreased protein expression of pro-inflammatory factors. SOD-1 was higher in LDE-MTX-treated rats (<i>p</i> &lt; 0.05). In conclusion, LDE-MTX treatment achieved total viability of cutaneous flaps, with increased irrigation and diminished local inflammation. LDE-MTX may offer efficient and cost-effective prevention of cutaneous flaps and treatment for wounds from surgical procedures to be tested in future clinical studies.
DOI: 10.6084/m9.figshare.27291183.v1
title: Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing

description: Skin flaps are employed to cover cutaneous denuded surfaces, but ensuing flap necrosis often occurs. Previously, rats with myocardial infarction treated with lipid-core nanoparticles (LDE) loaded with methotrexate (MTX) improved myocardial irrigation and reduced necrosis. Here, the aim was to investigate the efficacy of LDE-MTX to preserve the viability of cutaneous flaps and its implications for surgical wound healing. Twenty-eight male rats were divided into 4 groups: (1) LDE, injected intraperitoneally with LDE only; (2) MTX (1 mg/Kg commercial MTX): (3) LDE-MTX (1 mg/Kg MTX associated with LDE), and controls without treatment. LDE, MTX or LDE-MTX were repeated after 2 days. Then, flap surgery (9x3cm) was performed on the dorsal region. Injections were continued every other day until day 7 when animals were euthanized. LDE-MTX treatment improved the total viable area of the flaps with a fourfold increase in blood flow and reduced inflammatory cell number (<i>p</i> &lt; 0.001), accompanied by decreased protein expression of pro-inflammatory factors. SOD-1 was higher in LDE-MTX-treated rats (<i>p</i> &lt; 0.05). In conclusion, LDE-MTX treatment achieved total viability of cutaneous flaps, with increased irrigation and diminished local inflammation. LDE-MTX may offer efficient and cost-effective prevention of cutaneous flaps and treatment for wounds from surgical procedures to be tested in future clinical studies.
DOI: 10.17632/dwkh4yfm7f.4
title: Evaluation of Online Inquiry Competences of Chilean Elementary School Students

description: In 2022, a cross-sectional study was conducted to assess elementary students' online inquiry competences (OCI) within a quasi-realistic context. Our diagnostic framework encompasses a spectrum of information challenges within the natural sciences, stratified by grade level (i.e., 4th, 6th, and 8th grades), question category (i.e., closed-ended, descriptive, causal explanation, verification, prediction, difficulty (i.e., easy, intermediate, difficult), and generalization), and challenge type (i.e., open-ended response and source evaluation). To engage students in the diagnostic process while maintaining control over the information resources accessed during the search sessions, we used the Trivia game [1], powered by the NEURONE ecosystem [2]. Accordingly, both the challenges and the repository of information resources (e.g., web pages, images, and videos) were loaded onto the Trivia platform. This facilitated an experiential learning environment for students, simulating search experiences similar to those provided by contemporary search engines such as Google and Bing.
The diagnostic was administered to 169 students from three public schools and 110 students from a private educational institution within the metropolitan area of Chile. This work presents the resulting dataset, which encompasses behavioral, affective, and cognitive data derived from 1055 search sessions.

REFERENCES
1. González-Ibáñez R, Chourio-Acevedo L, Gacitúa D, Márquez C, Mellado J, Villarreal F, et al. Let’s Play: Toward an Effective Approach to Assess Online Inquiry Competences at School Level. In: 2021 40th International Conference of the Chilean Computer Science Society (SCCC). 2021. p. 1–8.
2. González-Ibáñez R, Gacitúa D, Sormunen E, Kiili C. Neurone: oNlinE inqUiRy experimentatiON systEm. Proc Assoc Inf Sci Technol. 2017;54(1):687–9.
DOI: 10.17632/w24kh54jmf.1
title: LDHU3_16.1890

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.6084/m9.figshare.28228532
title: Chromosome-level genome sequencing and assembly of the parasitoid wasp Leptopilina myrica

description: This dataset contains the genome assembly and annotation of <i>Leptopilina myrica.</i>
DOI: 10.6084/m9.figshare.28228403
title: Cell cycle distribution and EdU Index (Fig. 1E & Fig. S1A)

description: Juveniles were dissociated in pools of 15 polyps. Prior dissociation were labeled for 30 min with EdU (100uM, 2%DMSO) over several time points after feeding, and then dissociated and fixed using Trypsin/formaldehyde. Cells were stained with 1μg/ml FxCycle violet DNA dye (Invitrogen), EdU was labelled with Alexa647 using a Click-it reaction, and mOr2 was detected with anti-dsRed (Rabbit, Takara Bio Clontech 632496) and goat-anti-rabbit Alexa568.Flow cytometry was performed a BD LSRFortessa (BD Life Sciences) and the mOr2 and EdU positive cells in samples were determined based on Alexa568 and Alexa647 fluorescence in comparison with the negative controls on cells within the cell cycle (based on DNA staining) using FlowJoV10.8 (BD Life Sciences)..wsp files contain the samples, gating strategy and cell populations used for the analysis in FlowJo.fcs files represent the individual flow cytometry output files that were analysed in the .wsp file
DOI: 10.6084/m9.figshare.28228403.v1
title: Cell cycle distribution and EdU Index (Fig. 1E & Fig. S1A)

description: Juveniles were dissociated in pools of 15 polyps. Prior dissociation were labeled for 30 min with EdU (100uM, 2%DMSO) over several time points after feeding, and then dissociated and fixed using Trypsin/formaldehyde. Cells were stained with 1μg/ml FxCycle violet DNA dye (Invitrogen), EdU was labelled with Alexa647 using a Click-it reaction, and mOr2 was detected with anti-dsRed (Rabbit, Takara Bio Clontech 632496) and goat-anti-rabbit Alexa568.Flow cytometry was performed a BD LSRFortessa (BD Life Sciences) and the mOr2 and EdU positive cells in samples were determined based on Alexa568 and Alexa647 fluorescence in comparison with the negative controls on cells within the cell cycle (based on DNA staining) using FlowJoV10.8 (BD Life Sciences)..wsp files contain the samples, gating strategy and cell populations used for the analysis in FlowJo.fcs files represent the individual flow cytometry output files that were analysed in the .wsp file
DOI: 10.15468/dl.9jfq3p
title: Occurrence Download

description: A dataset containing 512 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ceratitis capitata (Wiedemann, 1824)",
 "Country is Australia",
 "Year is greater than or equal to 1500"
 ]
}

 The dataset includes 512 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000134-250117103327516/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/10496904
title: Public Opinion on Climate Change (Updated Daily)
DOI: 10.6084/m9.figshare.28228577
title: Cell cycle distribution and EdU Index (Fig. 1F & Fig. S1B)

description: uveniles were dissociated in pools of 15 polyps. Prior dissociation were labeled for 30 min with EdU (100uM, 2%DMSO) over several time points after feeding, and then dissociated and fixed using Trypsin/formaldehyde. Cells were stained with 1μg/ml FxCycle violet DNA dye (Invitrogen), EdU was labelled with Alexa647 using a Click-it reaction, and mOr2 was detected with anti-dsRed (Rabbit, Takara Bio Clontech 632496) and goat-anti-rabbit Alexa568.Flow cytometry was performed a BD LSRFortessa (BD Life Sciences) and the mOr2 and EdU positive cells in samples were determined based on Alexa568 and Alexa647 fluorescence in comparison with the negative controls on cells within the cell cycle (based on DNA staining) using FlowJoV10.8 (BD Life Sciences)..wsp files contain the samples, gating strategy and cell populations used for the analysis in FlowJo.fcs files represent the individual flow cytometry output files that were analysed in the .wsp file
DOI: 10.6084/m9.figshare.28228577.v1
title: Cell cycle distribution and EdU Index (Fig. 1F & Fig. S1B)

description: uveniles were dissociated in pools of 15 polyps. Prior dissociation were labeled for 30 min with EdU (100uM, 2%DMSO) over several time points after feeding, and then dissociated and fixed using Trypsin/formaldehyde. Cells were stained with 1μg/ml FxCycle violet DNA dye (Invitrogen), EdU was labelled with Alexa647 using a Click-it reaction, and mOr2 was detected with anti-dsRed (Rabbit, Takara Bio Clontech 632496) and goat-anti-rabbit Alexa568.Flow cytometry was performed a BD LSRFortessa (BD Life Sciences) and the mOr2 and EdU positive cells in samples were determined based on Alexa568 and Alexa647 fluorescence in comparison with the negative controls on cells within the cell cycle (based on DNA staining) using FlowJoV10.8 (BD Life Sciences)..wsp files contain the samples, gating strategy and cell populations used for the analysis in FlowJo.fcs files represent the individual flow cytometry output files that were analysed in the .wsp file
DOI: 10.15468/dl.7trugd
title: Occurrence Download

description: A dataset containing 5221 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lathyrus inconspicuus L."
 ]
}

 The dataset includes 5221 records from 216 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000133-250117103327516/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2kds3p
title: Occurrence Download

description: A dataset containing 4594 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Material citation, Living Specimen, Occurrence evidence)",
 "TaxonKey is Bulinus O.F.Müller, 1781"
 ]
}

 The dataset includes 4594 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000135-250117103327516/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28156352.v1
title: Unpredictable plant-soil feedbacks in diverse plant communities based on species-level studies

description: Our study revealed that when soil was conditioned by more than four species, community-level PSFs were dominated by specific species rather than being an aggregation of single-species PSFs. This pattern may occur because rhizosphere fungal communities are co-influenced by both host and neighbouring species diversity.
DOI: 10.15468/dl.sghkn8
title: Occurrence Download

description: A dataset containing 114186 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hydrocharis morsus-ranae L."
 ]
}

 The dataset includes 114186 records from 605 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000127-250117103327516/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ybd7jg
title: Occurrence Download

description: A dataset containing 2796625 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Salmo trutta Linnaeus, 1758"
 ]
}

 The dataset includes 2796625 records from 712 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000129-250117103327516/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/4y7-hl5-ws7
title: Calamagrostis canescens (Weber) Roth

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y7-jyz-n84
title: Trifolium spadiceum L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y7-rg2-qbf
title: Sesleria uliginosa Opiz

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y7-szr-whz
title: Plantae

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-91z-v8d
title: Lycopodium clavatum subsp. clavatum

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-atv-md5
title: Achnatherum calamagrostis (L.) P.Beauv.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-c7t-004
title: Trifolium medium L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-dhz-ry7
title: Dryopteris cristata (L.) A. Gray

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-en6-hj5
title: Corallorhiza trifida Châtel.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-mae-87a
title: Luzula multiflora subsp. frigida (Buchenau) V. I. Krecz.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-plj-s6h
title: Dactylorhiza maculata (L.) Soó

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-rzl-fcw
title: Cypripedium calceolus L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-zpv-67e
title: Neottia cordata (L.) Rich.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-145-0d1
title: Equisetum palustre L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-21e-69r
title: Dryas octopetala L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y8-yvh-m2r
title: Alchemilla glomerulans Buser

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-62d-8lf
title: Persicaria lapathifolia subsp. brittingeri (Opiz) Soják

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-9ee-gak
title: Actaea spicata L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-ah0-gv3
title: Alchemilla glaucescens Wallr.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-h3v-f67
title: Molinia caerulea (L.) Moench

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-me6-fhh
title: Carex acuta L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-p70-l8s
title: Sparganium hyperboreum Laest. ex Beurl.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-pap-fxy
title: Carex nigra (L.) Reichard

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-pnt-5sn
title: Typha angustifolia L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-qte-zc5
title: Phleum pratense L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-sy8-5lg
title: Chelidonium majus L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-wy8-ykr
title: Dianthus superbus L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4y9-yx6-l2w
title: Rorippa sylvestris (L.) Besser

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4ya-2ef-s6b
title: Carex aquatilis Wahlenb.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4ya-3y3-llg
title: Carex vesicaria L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4ya-7lw-a3t
title: Lolium perenne L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.
DOI: 10.3535/4ya-8zt-hsw
title: Myrica gale L.

description: Digital Specimen for the physical specimen hosted at Finnish Museum of Natural History.