cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5747797
title: A Rapid and Simple UHPLC-MS/MS Method for Quantification of Plasma Globotriaosylsphingosine (lyso-Gb3)

description: Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by α-galactosidase A gene (GLA) mutations, resulting in loss of activity of the lysosomal hydrolase, α-galactosidase A (α-Gal A). As a result, the main glycosphingolipid substrates, globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3), accumulate in plasma, urine, and tissues. Here, we propose a simple, fast, and sensitive method for plasma quantification of lyso-Gb3, the most promising secondary screening target for FD. Assisted protein precipitation with methanol using Phree cartridges was performed as sample pre-treatment and plasma concentrations were measured using UHPLC-MS/MS operating in MRM positive electrospray ionization. Method validation provided excellent results for the whole calibration range (0.25–100 ng/mL). Intra-assay and inter-assay accuracy and precision (CV%) were calculated as &lt;10%. The method was successfully applied to 55 plasma samples obtained from 34 patients with FD, 5 individuals carrying non-relevant polymorphisms of the GLA gene, and 16 healthy controls. Plasma lyso-Gb3 concentrations were larger in both male and female FD groups compared to healthy subjects (<em>p </em>&lt; 0.001). Normal levels of plasma lyso-Gb3 were observed for patients carrying non-relevant mutations of the GLA gene compared to the control group (<em>p </em>= 0.141). Dropping the lower limit of quantification (LLOQ) to 0.25 ng/mL allowed us to set the optimal plasma lyso-Gb3 cut-off value between FD patients and healthy controls at 0.6 ng/mL, with a sensitivity of 97.1%, specificity of 100%, and accuracy of 0.998 expressed by the area under the ROC curve (C.I. 0.992 to 1.000, <em>p</em>-value &lt; 0.001). Based on the results obtained, this method can be a reliable tool for early phenotypic assignment, assessing diagnoses in patients with borderline GalA activity, and confirming non-relevant mutations of the GLA gene.
DOI: 10.25919/r5c8-pk51
title: Parkes pulsar observations with undefined project IDs for 2022APRS_10

description: Parkes pulsar observations with undefined project IDs for 2022APRS. This collection contains observations from project IDs PX085, PX087 and PX088.
DOI: 10.5281/zenodo.6907700
title: Data and scripts used in paper on critique of CV

description: No description
DOI: 10.5281/zenodo.6907699
title: Data and scripts used in paper on critique of CV

description: No description
DOI: 10.25934/pr00007402.2
title: Available IPD datapackage for study 'A Phase I/III, Randomized, Double-Blind, Placebo-Controlled Study of Carboplatin Plus Etoposide With or Without Atezolizumab (Anti-PD-L1 Antibody) in Patients With Untreated Extensive-Stage Small Cell Lung Cancer'

description: This randomized, Phase I/III, multicenter, double-blinded, placebo-controlled study was designed to evaluate the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 [PD-L1] antibody) in combination with carboplatin plus (+) etoposide compared with treatment with placebo + carboplatin + etoposide in chemotherapy-naive participants with ES-SCLC. Participants will be randomized in a 1:1 ratio to receive either atezolizumab + carboplatin + etoposide or placebo + carboplatin + etoposide on 21-day cycles for four cycles in the induction phase followed by maintenance with atezolizumab or placebo until progressive disease (PD) as assessed by the investigator using Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1). Treatment can be continued until persistent radiographic PD or symptomatic deterioration.
DOI: 10.25934/pr00007830
title: Cost effectiveness analysis of atezolizumab plus chemotherapy for untreated extensive stage small cell lung cancer in Asia

description: Extensive stage small cell lung cancer (ES-SCLC) is an aggressive form of lung cancer that grows rapidly and spreads extensively, which means the cancer has spread widely throughout the lung, to the other lung or to other organs. Although the standard chemotherapy (CTX) shows 60%–80% overall response rate for ES-SCLC, the majority of patients relapse within 6 months and the 5-year survival rate is only about 2%. 

Currently, atezolizumab has been investigated for treatment naive ES-SCLC with significant survival benefit. However, combination regimen with atezolizumab plus standard CTX was found not cost-effective compared with CTX alone in research of the US setting. Adding atezolizumab to CTX results in additional 0.10 quality adjusted life years [The quality-adjusted life year (QALY) is a standard to measure the disease burden. QUALY also can be applied to present how well a medical intervention lengthen or improve patients’ lives] and corresponding incremental costs $52,881, leading to an incremental cost effective ratio (ICER) of $528,810 per QALY. ICER provides a ratio of extra cost per unit of health effect. ICER is calculated by dividing the difference in cost between two interventions by the difference in their treatment effect. 

In terms of Asian population, genetic and physical differences can alter the efficacy and incidence of treatment-related adverse events. Therefore, subgroup effect on cost and effectiveness between Asian and non Asian is important to emphasize. Hence, our study intends to evaluate the cost effectiveness of atezolizumab plus CTX for newly diagnosed ES-SCLC compared to the current standard CTX with etoposide and platinum (EP) and explore the subgroup effect under Asian settings. We will derive the efficacy, safety and utility data from the IMpower133 trial and consider the costs of atezolizumab, CTX, symptom relief therapy, palliative care and management for grade≥3 adverse events from the local charges. Grade ≥3 AEs include severe or life-threatening AEs and death related to AEs. In our study, we will present the medical utilization and cost for treating the Grade ≥3 AEs from the local charges by Taiwan dollar.  

We will analyze the model by TreeAge Pro 2017 (TreeAge Software, Williamstown, MA) to estimate the economic outcomes, such as lifetime costs life years and QALYs. QALY gained and estimate of overall costs will be used to evaluate the ICER. Adding atezolizumab to CTX will be regarded as cost-effective as the ICER is less than three times of the national annual gross domestic product (GDP) per capita. Furthermore, we will perform one-way and probabilistic sensitivity analyses to observe the uncertainty. Results of our study will be applied to identify patients who benefit from this intervention the most and provide evidence for decision making in insurance coverage.
DOI: 10.7284/148852
title: Expendable Probe data collected during research cruise LMG0613 using a Sippican MK21 instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148853
title: Expendable Probe data collected during research cruise LMG0613 using a Sippican MK21 instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148858
title: Fluorometer data collected during research cruise LMG0613 using a Turner 10-AU instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148855
title: GNSS (Global Navigation Satellite System) data collected during research cruise LMG0613 using a Ashtech ADU2 instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148856
title: GNSS (Global Navigation Satellite System) data collected during research cruise LMG0613 using a Garmin GPS-17HVS instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148859
title: GNSS (Global Navigation Satellite System) data collected during research cruise LMG0613 using a Trimble Centurion P(Y) instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148860
title: Gyrocompass data collected during research cruise LMG0613 using a SGB Meridian instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148575
title: Anemometer data collected during research cruise SKQ202110S using a RMYoung 85004 instrument system onboard the platform RV Sikuliaq

description: Processed data created by vessel technician during a Field_expedition
DOI: 10.7284/148569
title: Flowmeter data collected during research cruise SKQ202110S using a Krohne Optiflux 5000 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148574
title: Fluorometer data collected during research cruise SKQ202110S using a WETLabs WETStar instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148573
title: GNSS (Global Navigation Satellite System) data collected during research cruise SKQ202110S using a CCTech C-Nav 3050 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148572
title: Gravimeter data collected during research cruise SKQ202110S using a Bell BGM-3 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148570
title: Gyrocompass data collected during research cruise SKQ202110S using a Sperry NAVIGAT 2100 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148571
title: Gyrocompass data collected during research cruise SKQ202110S using a Sperry NAVIGAT 2100 instrument system onboard the platform RV Sikuliaq

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.5281/zenodo.5933722
title: List of DNS over HTTPS resolvers on the internet

description: The DoH Internet Servers dataset comprises a verified list of Internet servers offering DNS over HTTPS (DoH) service. The list was created by active scanning of the IPv4 address space. The scanning was done two times in April 2021 and in January 2022. Together, the list contains 1987 different IP addresses with their reverse DNS record (if available), supported DoH method, and TLS 1.3 support. The scanning was done in three phases: We scanned the IPv4 address space for opened port 443 using masscan. IP addresses found in the previous step were scanned for DoH support using a custom Nmap-NSE script. The IP addresses found in previous steps were reached by a slower python script that also validated responses, obtained domain names. <strong>Scanning limitation: </strong>The main limitation of our scanning was that it could not find DoH resolvers hosted on infrastructures hosting multiple services behind a single IP address. In such cases, an SNI, or HTTP Host header, or HTTP/2 <em>:authority</em> header is needed for a successful request. Since we did not have the SNI, it was impossible to provide it. <strong>Used Scripts:</strong> NMap: https://github.com/cejkato2/dns-doh.nse<br> Python: https://github.com/hynekkar/DoH-Checker
DOI: 10.5281/zenodo.4923370
title: List of DNS over HTTPS resolvers on the internet

description: The DoH Internet Servers dataset comprises a verified list of Internet servers offering DNS over HTTPS (DoH) service. The list was created by active scanning of the IPv4 address space. The scanning was done two times in April 2021 and in January 2022. Together, the list contains 1987 different IP addresses with their reverse DNS record (if available), supported DoH method, and TLS 1.3 support. The scanning was done in three phases: We scanned the IPv4 address space for opened port 443 using masscan. IP addresses found in the previous step were scanned for DoH support using a custom Nmap-NSE script. The IP addresses found in previous steps were reached by a slower python script that also validated responses, obtained domain names. <strong>Scanning limitation: </strong>The main limitation of our scanning was that it could not find DoH resolvers hosted on infrastructures hosting multiple services behind a single IP address. In such cases, an SNI, or HTTP Host header, or HTTP/2 <em>:authority</em> header is needed for a successful request. Since we did not have the SNI, it was impossible to provide it. <strong>Used Scripts:</strong> NMap: https://github.com/cejkato2/dns-doh.nse<br> Python: https://github.com/hynekkar/DoH-Checker
DOI: 10.5281/zenodo.6907738
title: Potamosilurus velutinus RB0352 ARBOR decontaminated gx

description: .
DOI: 10.5281/zenodo.6907737
title: Potamosilurus velutinus RB0352 ARBOR decontaminated gx

description: .
DOI: 10.3886/icpsr38461.v1
title: Subsidized and Transitional Employment Demonstration (STED), San Francisco, California, 2012-2018
title: Version 1

description: The STEP Forward program offered job seekers opportunities to interview for jobs with private sector employers at weekly job fairs, and offered employers temporary wage subsidies to encourage them to try out job seekers whom they might not otherwise hire, with the goal of ultimately hiring these workers into permanent unsubsidized employment. A diverse group of low-income job seekers enrolled in the program, the vast majority of whom were either CalWORKs (California's Temporary Assistance for Needy Families program) clients, individuals who had exhausted their unemployment insurance benefits, or CalFresh (California's Supplemental Nutrition Assistance Program) recipients. MDRC's evaluation, conducted as a randomized controlled trial, included an implementation study, an impact study, and a cost analysis. This program was one of several evaluated as part of the Subsidized and Transitional Employment Demonstration (STED) project. These data are a Fast Track Release and are distributed as they were received from the data depositor. The files have been zipped for release, but not checked or processed.
description: The full research sample for the San Francisco STEP Forward study consisted of 811 individuals who were randomly assigned between November 2012 and March 2015. The sample includes 414 individuals in the program group and 397 individuals in the control group.
description: Datasets: DS1: Subsidized and Transitional Employment Demonstration (STED), San Francisco, California, 2012-2018
description: Low-income job seekers, the vast majority of whom were either CalWORKs (California's Temporary Assistance for Needy Families program) clients, individuals who had exhausted their unemployment insurance benefits, or CalFresh (California's Supplemental Nutrition Assistance Program) recipients.
description: For additional information, users can visit the MDRC website.
DOI: 10.3886/icpsr38461
title: Subsidized and Transitional Employment Demonstration (STED), San Francisco, California, 2012-2018
title: Archival Version

description: The STEP Forward program offered job seekers opportunities to interview for jobs with private sector employers at weekly job fairs, and offered employers temporary wage subsidies to encourage them to try out job seekers whom they might not otherwise hire, with the goal of ultimately hiring these workers into permanent unsubsidized employment. A diverse group of low-income job seekers enrolled in the program, the vast majority of whom were either CalWORKs (California's Temporary Assistance for Needy Families program) clients, individuals who had exhausted their unemployment insurance benefits, or CalFresh (California's Supplemental Nutrition Assistance Program) recipients. MDRC's evaluation, conducted as a randomized controlled trial, included an implementation study, an impact study, and a cost analysis. This program was one of several evaluated as part of the Subsidized and Transitional Employment Demonstration (STED) project. These data are a Fast Track Release and are distributed as they were received from the data depositor. The files have been zipped for release, but not checked or processed.
description: The full research sample for the San Francisco STEP Forward study consisted of 811 individuals who were randomly assigned between November 2012 and March 2015. The sample includes 414 individuals in the program group and 397 individuals in the control group.
description: Datasets: DS1: Subsidized and Transitional Employment Demonstration (STED), San Francisco, California, 2012-2018
description: Low-income job seekers, the vast majority of whom were either CalWORKs (California's Temporary Assistance for Needy Families program) clients, individuals who had exhausted their unemployment insurance benefits, or CalFresh (California's Supplemental Nutrition Assistance Program) recipients.
description: For additional information, users can visit the MDRC website.
DOI: 10.34740/kaggle/dsv/3988612
title: COVID Vaccination in World (updated daily)
DOI: 10.21227/byxs-4g06
title: Test Two

description: Hello World
DOI: 10.13020/pmxd-dp53
title: Crowdsourcing a music playlist for curating data
DOI: 10.34740/kaggle/dsv/3988577
title: Harumanis_Mango_Physical_Measurement
DOI: 10.34740/kaggle/dsv/3979033
title: Nepse Index Historical Data
DOI: 10.5281/zenodo.6907187
title: data sets from "Updated trends of the stratospheric ozone vertical distribution in the 60S–60N latitude range based on the LOTUS regression model"

description: Monthly means data sets from satellite, ground-based and model records used in the article entitled: "Updated trends of the stratospheric ozone vertical distribution in the 60 S–60 N latitude range based on the LOTUS regression model"
DOI: 10.5281/zenodo.6907186
title: data sets from "Updated trends of the stratospheric ozone vertical distribution in the 60S–60N latitude range based on the LOTUS regression model"

description: Monthly means data sets from satellite, ground-based and model records used in the article entitled: "Updated trends of the stratospheric ozone vertical distribution in the 60 S–60 N latitude range based on the LOTUS regression model"
DOI: 10.7284/148867
title: GNSS (Global Navigation Satellite System) data collected during research cruise LMG0612 using a Ashtech ADU2 instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148868
title: GNSS (Global Navigation Satellite System) data collected during research cruise LMG0612 using a Garmin GPS-17HVS instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148871
title: GNSS (Global Navigation Satellite System) data collected during research cruise LMG0612 using a Trimble Centurion P(Y) instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/148872
title: Gyrocompass data collected during research cruise LMG0612 using a SGB Meridian instrument system onboard the platform RV Laurence M. Gould

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.34740/kaggle/dsv/3988026
title: Aparat Videos
DOI: 10.17034/5c546377-435e-4219-9c69-b33c5dabe554
title: Excerpts from a reflective diary as a novice qualitative researcher

description: Reflexivity is the process of examining oneself as a researcher and the research relationship. It involves self-reflection of personal assumptions and preconceptions, and how these will potentially affect research decisions, at all stages in the research process and is of particular importance for a novice researcher (Peddle, 2021). It includes actively examining and reflecting on the research relationship between myself as the researcher and the participants, and how the dynamics of this relationship may affect the research process (Gabriel, 2015). Reflexivity involves self-reflection by the researcher, at all stages of the research process to demonstrate the trustworthiness of their methodology and findings (Berger, 2015, Dodgson, 2019). A recommended approach is by recording a reflective diary throughout the research process (Finlay and Gough, 2003, Reid et al, 2018, Nadin and Cassell, 2006). My reflective diary was a notebook that I used to write down my thoughts when each interview, and the focus group were complete. Reflections on the overall encounter were noted, what issues if any were identified, such as practical issues with the interview schedule, equipment issues and generally how I felt the interview went. I included comments relating to how I had experienced the interview process, especially with the early interviews where I noted my observations as a researcher. This dataset would be of interest to novice researchers engaging in data collection of individual interviews and focus groups within the research fields of social science, nursing, midwifery and education.
DOI: 10.26190/p5c8-te58
title: River-tide interaction model

description: River-tide interaction in the Ganges-Brahmaputra-Meghna Delta
DOI: 10.26190/3hb4-sx82
title: Data for the paper entitled 'Resonant Monochromatic Electron Emission through Monolayer Quantum Dots '

description: 190K I-V curves are the main experimental results. temp I-V curves are the results for temperature-dependent measurements. side-mode I-ï¼ curves are used for side-mode discussion.
DOI: 10.5281/zenodo.6907916
title: Merluccius polylepis decontaminated gx

description: .
DOI: 10.5281/zenodo.6907915
title: Merluccius polylepis decontaminated gx

description: .
DOI: 10.6084/m9.figshare.19793119
title: Training dataset

description: This dataset consists of a set of manually annotated fluoroscopy images in which the contrast-filled bladder was imaged from various angles and at different stages of the filling/voiding cycle.
DOI: 10.26190/unsworks/1236
title: Potentiometric alkali titration data for the full tripeptide set composed from the combination of Glutamic acid (Glu, E), Glycine (Gly, G) and Histidine (His, H), measured between pH 3-12

description: Peptides were purchased from Genosphere, Sigma Aldrich and Bachem companies. All the peptides were chemically synthesised. Aldrich and Bachem supplied the peptides as their Zwitterionic form, Genosphere synthesised the peptides as tri-fluoro acetic salt TFA salts. The peptides were of purity higher than 98% and were used without any further purification.All peptides solutions were prepared at 0.001M concentration in milliQ water, Hydrochloric acid HCl 0.002M in order to have relatively the same initial pH of 2.6 valueThe potentiometric titrations were recorded at 25°C in 10ml conical flask under Nitrogen atmosphere. NaCLO4 sodium perchlorate was used as ino background at 0.1M to maintain relatively a consistent ionic strength during titration. Standardised NaOH 0.1M was the titrant, and it was added as 5µM increment until pH reaches 11.
description: http://hdl.handle.net/1959.4/004_128
DOI: 10.5281/zenodo.6907936
title: Oenothera biennis decontaminated gx

description: .
DOI: 10.5281/zenodo.6907935
title: Oenothera biennis decontaminated gx

description: .
DOI: 10.26190/unsworks/1290
title: FTIR Analysis of Artificially Aged Microfiltration Membranes

description: This collection contains information regarding the analysis of a range of microfiltration membranes and the influence of various chemicals on their surface chemistry. The dataset contains membranes that are made from PVDF, PP, PES in both flatsheet and hollow fibre configurations. These membranes have been exposed to sodium hypochlorite, sodium dodecyl sulphate, hydrochloric acid and sodium hydroxide. (note: not all membranes have been exposed to all chemicals). The FTIR analysis was conducted on a Bruker IFS66 FTIR Microscope.
description: http://hdl.handle.net/1959.4/004_128
description: http://hdl.handle.net/1959.4/004_319