cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21383000
title: Additional file 1 of Uncovering the genetic basis of gluten aggregation parameters by genome-wide association analysis in wheat (Triticum aestivum L.) using GlutoPeak

description: Additional file1: Table S1. Phenotypic values, mean values, and BLUP values of GlutoPeak parameters in the association panel under three environments. Table S2. Phenotypic analysis of GlutoPeak parameters in different environments. Table S3. Correlations between different GlutoPeak parameters. Table S4. SNPs significantly associated with GlutoPeak parameters. Table S5. QTLs for GlutoPeak parameters detected in association panel based on three environments and BLUP values. Table S6. Allele statistics of QTL cluster for GlutoPeak parameter. Table S7. KASP primers designed based on  Peak SNP sequence. Table S8. Analysis of variation indifferent alleles. Table S9. Candidate genes with significantly different expression in AX-111083649 and AX-95660756. Table S10. The same or adjacent QTLs in this study and previous studies.
DOI: 10.6084/m9.figshare.21383000.v1
title: Additional file 1 of Uncovering the genetic basis of gluten aggregation parameters by genome-wide association analysis in wheat (Triticum aestivum L.) using GlutoPeak

description: Additional file1: Table S1. Phenotypic values, mean values, and BLUP values of GlutoPeak parameters in the association panel under three environments. Table S2. Phenotypic analysis of GlutoPeak parameters in different environments. Table S3. Correlations between different GlutoPeak parameters. Table S4. SNPs significantly associated with GlutoPeak parameters. Table S5. QTLs for GlutoPeak parameters detected in association panel based on three environments and BLUP values. Table S6. Allele statistics of QTL cluster for GlutoPeak parameter. Table S7. KASP primers designed based on  Peak SNP sequence. Table S8. Analysis of variation indifferent alleles. Table S9. Candidate genes with significantly different expression in AX-111083649 and AX-95660756. Table S10. The same or adjacent QTLs in this study and previous studies.
DOI: 10.6084/m9.figshare.25273633
title: Supplementary Material for: Diffuse Leptomeningeal Glioneuronal Tumor in Adults: Case Report and Literature Review

description: <b><i>Introduction:</i></b> Diffuse leptomeningeal glioneuronal tumor (DLGNT), a new addition to the 2016 World Health Organization (WHO) classification, is a rare childhood neoplasm presenting with disseminated leptomeningeal enhancement and an occasional intraparenchymal mass. Diagnosis is often impeded by infectious/immunological differentials, necessitating a biopsy to confirm the diagnosis. We report an adult male with DLGNT without hydrocephalus, which is rare in patients with cerebellar masses. <b><i>Case Presentation:</i></b> A 56-year-old man presented with headaches, vertigo, diplopia, impaired hearing, and gait imbalance over 6 months. Magnetic resonance imaging showed a cystic right cerebellar mass with its leptomeningeal dissemination but without hydrocephalus. Cerebrospinal fluid analysis revealed elevated proteins with CD56-positive tumor cells. Cerebellar lesion biopsy verified the diagnosis of DLGNT (WHO Grade 3) with <i>KIAA1549::BRAF</i> fusion and 1p deletion. Radiotherapy was prematurely aborted due to clinical deterioration. The patient was subsequently discharged to palliative home care and lost to follow-up. <b><i>Conclusion:</i></b> We conducted the first review of all 34 adult DLGNT cases, including ours (one of the oldest), hitherto published in the literature. The majority presented with signs and symptoms of increased intracranial pressure. 52.0% of adult DLGNT patients were alive at follow-up. DLGNT should be considered in the differential diagnoses of diffuse leptomeningeal enhancement in imaging. Further studies comparing pediatric and adult subgroups of DLGNT are needed to evaluate histopathological prognosticators and standardize therapy for both subpopulations.
DOI: 10.6084/m9.figshare.25273636
title: Supplementary Material for: Resection of Renal Cell and Prostate Carcinoma Sternum Metastases with Long-Term Follow-Up: A Report of 2 Cases

description: <b><i>Introduction:</i></b> Rarely solitary sternum metastases are addressed by resection. Two additional cases are presented as they are interesting because of their long-term follow-up. <b><i>Case Presentation:</i></b> Case 1: A renal cell carcinoma was treated by transabdominal nephrectomy at age 64. Right iliac bone and sternum metastases were diagnosed 7 months later and treated by internal hemipelvectomy followed by sternum metastasectomy 6 weeks after the internal hemipelvectomy. At 12-year follow-up, the patient appears disease free. Case 2: Prostate cancer was treated by prostatectomy at age 67. A subsequent solitary sternum metastasis was resected 10 years later for persistent PSA-activity despite repeated radiotherapy. The patient remains asymptomatic for 3 years now. <b><i>Conclusion:</i></b> Resection of sternum metastases may have curative potential and should be considered in tumours known to be rather resistant to chemo- and/or radiotherapy.
DOI: 10.6084/m9.figshare.25273636.v1
title: Supplementary Material for: Resection of Renal Cell and Prostate Carcinoma Sternum Metastases with Long-Term Follow-Up: A Report of 2 Cases

description: <b><i>Introduction:</i></b> Rarely solitary sternum metastases are addressed by resection. Two additional cases are presented as they are interesting because of their long-term follow-up. <b><i>Case Presentation:</i></b> Case 1: A renal cell carcinoma was treated by transabdominal nephrectomy at age 64. Right iliac bone and sternum metastases were diagnosed 7 months later and treated by internal hemipelvectomy followed by sternum metastasectomy 6 weeks after the internal hemipelvectomy. At 12-year follow-up, the patient appears disease free. Case 2: Prostate cancer was treated by prostatectomy at age 67. A subsequent solitary sternum metastasis was resected 10 years later for persistent PSA-activity despite repeated radiotherapy. The patient remains asymptomatic for 3 years now. <b><i>Conclusion:</i></b> Resection of sternum metastases may have curative potential and should be considered in tumours known to be rather resistant to chemo- and/or radiotherapy.
DOI: 10.6084/m9.figshare.21383084
title: Additional file 3 of Efficacy and safety of Tripterygium wilfordii polyglycosides for diabetic kidney disease: an overview of systematic reviews and meta-analyses

description: Additional file 3: Supplemental Table 1. Overview of 24-hour Urinary Protein in the Included SRs and MAs. Supplemental Table 2. Overview of the Included SRs and MAs of Renal Function. Supplemental Table 3. Overview of the Included SRs and MAs about the Outcome of Serum Albumin. Supplemental Table 4. Overview of the Included SRs and MAs of AL. Supplemental Table 5. Overview of the included SRs and MAs about the outcomes of WBC. Supplemental Table 6. Overview of the Incidence of Adverse Events in the Included SRs and MAs. Supplemental Table 7. Methodological Quality Assessment of the Systematic Reviews and Meta-analyses Based on AMSTAR-2 tool. Supplemental Table 8. Quality of Evidence in Included SRs with GRADE.
DOI: 10.6084/m9.figshare.11945964
title: Additional file 5 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 5 Table S3. GO classification of DEGs in stem and leaf.
DOI: 10.6084/m9.figshare.21907459
title: Racial Differences in Retinopathy of Prematurity

description: To delineate racial differences in the incidence and time course of ROP in a large cohort of premature infants. The secondary analysis of data from the two Postnatal Growth and ROP Studies (G-ROP-1 and G-ROP-2) that were collected in 41 hospitals in North America from 2006 to 2017. According to self-reported maternal race, premature infants were classified into 3 groups: White (N = 5580), Black (N = 3252), and Asian (N = 353). Incidence, severity, and time course of ROP; plus disease; and postnatal weight gain rate were compared among racial groups. Black infants had significantly smaller BW (mean 1035 vs. 1131 vs.1144 grams, P &lt; .001) and lower GA (28.2 vs. 28.6, vs. 29.1 weeks, P &lt; .001) than White and Asian infants. However, Black infants had lower incidences of severe ROP (11.1% vs. 12.4% vs. 11.9%), ROP (42.1% vs. 43.2% vs. 30.6%), and plus disease (3.6% vs. 6.3%, vs. 5.9%) than White and Asian infants (BW and GA adjusted risk ratio for Black vs. White 0.69 for severe ROP, 0.83 for ROP, 0.44 for plus disease, all P &lt; .0001). Mean daily-weight-gain on days of life 11–20 and 21–30 were similar across groups (P &gt; .05), but lower in Black and Asian infants on days 31–40 (P &lt; .001). There were no differences in the timing of severe ROP and ROP across racial groups. Despite relatively lower GA, BW, and daily-weight-gain, Black preterm infants had lower incidences of ROP and plus disease than White preterm infants. The mechanisms for these differences require further investigation.
DOI: 10.6084/m9.figshare.25273633.v1
title: Supplementary Material for: Diffuse Leptomeningeal Glioneuronal Tumor in Adults: Case Report and Literature Review

description: <b><i>Introduction:</i></b> Diffuse leptomeningeal glioneuronal tumor (DLGNT), a new addition to the 2016 World Health Organization (WHO) classification, is a rare childhood neoplasm presenting with disseminated leptomeningeal enhancement and an occasional intraparenchymal mass. Diagnosis is often impeded by infectious/immunological differentials, necessitating a biopsy to confirm the diagnosis. We report an adult male with DLGNT without hydrocephalus, which is rare in patients with cerebellar masses. <b><i>Case Presentation:</i></b> A 56-year-old man presented with headaches, vertigo, diplopia, impaired hearing, and gait imbalance over 6 months. Magnetic resonance imaging showed a cystic right cerebellar mass with its leptomeningeal dissemination but without hydrocephalus. Cerebrospinal fluid analysis revealed elevated proteins with CD56-positive tumor cells. Cerebellar lesion biopsy verified the diagnosis of DLGNT (WHO Grade 3) with <i>KIAA1549::BRAF</i> fusion and 1p deletion. Radiotherapy was prematurely aborted due to clinical deterioration. The patient was subsequently discharged to palliative home care and lost to follow-up. <b><i>Conclusion:</i></b> We conducted the first review of all 34 adult DLGNT cases, including ours (one of the oldest), hitherto published in the literature. The majority presented with signs and symptoms of increased intracranial pressure. 52.0% of adult DLGNT patients were alive at follow-up. DLGNT should be considered in the differential diagnoses of diffuse leptomeningeal enhancement in imaging. Further studies comparing pediatric and adult subgroups of DLGNT are needed to evaluate histopathological prognosticators and standardize therapy for both subpopulations.
DOI: 10.6084/m9.figshare.8276015.v1
title: Additional file 21: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S13. Homologs of Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.11945964.v1
title: Additional file 5 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 5 Table S3. GO classification of DEGs in stem and leaf.
DOI: 10.6084/m9.figshare.7227470
title: Flexible planning, executive function and language in young children

description: Flexible planning, executive function and language in young children
DOI: 10.6084/m9.figshare.11945982
title: Additional file 7 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 7 Table S4. The top 20 enriched GO terms of DEGs in stem and leaf.
DOI: 10.6084/m9.figshare.21383084.v1
title: Additional file 3 of Efficacy and safety of Tripterygium wilfordii polyglycosides for diabetic kidney disease: an overview of systematic reviews and meta-analyses

description: Additional file 3: Supplemental Table 1. Overview of 24-hour Urinary Protein in the Included SRs and MAs. Supplemental Table 2. Overview of the Included SRs and MAs of Renal Function. Supplemental Table 3. Overview of the Included SRs and MAs about the Outcome of Serum Albumin. Supplemental Table 4. Overview of the Included SRs and MAs of AL. Supplemental Table 5. Overview of the included SRs and MAs about the outcomes of WBC. Supplemental Table 6. Overview of the Incidence of Adverse Events in the Included SRs and MAs. Supplemental Table 7. Methodological Quality Assessment of the Systematic Reviews and Meta-analyses Based on AMSTAR-2 tool. Supplemental Table 8. Quality of Evidence in Included SRs with GRADE.
DOI: 10.6084/m9.figshare.8276015
title: Additional file 21: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S13. Homologs of Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.11945982.v1
title: Additional file 7 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 7 Table S4. The top 20 enriched GO terms of DEGs in stem and leaf.
DOI: 10.6084/m9.figshare.11945991
title: Additional file 8 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 8 Table S5. The top 20 enriched KEGG pathways of DEGs in stem and leaf.
DOI: 10.6084/m9.figshare.11945991.v1
title: Additional file 8 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 8 Table S5. The top 20 enriched KEGG pathways of DEGs in stem and leaf.
DOI: 10.6084/m9.figshare.11945997
title: Additional file 9 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 9 Table S6. Validation of RNA-seq results via qRT-PCR.
DOI: 10.6084/m9.figshare.11945997.v1
title: Additional file 9 of Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant

description: Additional file 9 Table S6. Validation of RNA-seq results via qRT-PCR.
DOI: 10.6084/m9.figshare.21907459.v1
title: Racial Differences in Retinopathy of Prematurity

description: To delineate racial differences in the incidence and time course of ROP in a large cohort of premature infants. The secondary analysis of data from the two Postnatal Growth and ROP Studies (G-ROP-1 and G-ROP-2) that were collected in 41 hospitals in North America from 2006 to 2017. According to self-reported maternal race, premature infants were classified into 3 groups: White (N = 5580), Black (N = 3252), and Asian (N = 353). Incidence, severity, and time course of ROP; plus disease; and postnatal weight gain rate were compared among racial groups. Black infants had significantly smaller BW (mean 1035 vs. 1131 vs.1144 grams, P &lt; .001) and lower GA (28.2 vs. 28.6, vs. 29.1 weeks, P &lt; .001) than White and Asian infants. However, Black infants had lower incidences of severe ROP (11.1% vs. 12.4% vs. 11.9%), ROP (42.1% vs. 43.2% vs. 30.6%), and plus disease (3.6% vs. 6.3%, vs. 5.9%) than White and Asian infants (BW and GA adjusted risk ratio for Black vs. White 0.69 for severe ROP, 0.83 for ROP, 0.44 for plus disease, all P &lt; .0001). Mean daily-weight-gain on days of life 11–20 and 21–30 were similar across groups (P &gt; .05), but lower in Black and Asian infants on days 31–40 (P &lt; .001). There were no differences in the timing of severe ROP and ROP across racial groups. Despite relatively lower GA, BW, and daily-weight-gain, Black preterm infants had lower incidences of ROP and plus disease than White preterm infants. The mechanisms for these differences require further investigation.
DOI: 10.6084/m9.figshare.8275991.v1
title: Additional file 17: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S10. Homolog of two-component system encoding genes in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8276003
title: Additional file 19: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S11. Identification of homologs of flagellar and chemotaxis genes in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.8275991
title: Additional file 17: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S10. Homolog of two-component system encoding genes in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.8276021.v1
title: Additional file 22: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S14. Lists of CRISPR target viruses or plasmids based on spacer sequences among Pectobacterium spp. (XLSX 33 kb)
DOI: 10.6084/m9.figshare.8276003.v1
title: Additional file 19: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S11. Identification of homologs of flagellar and chemotaxis genes in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.11946003
title: Additional file 1 of ADMET evaluation in drug discovery. 20. Prediction of breast cancer resistance protein inhibition through machine learning

description: Additional file 1: Table S1. The detailed descriptions of the final dataset containing 1098 BCRP inhibitors and 1701 BCRP non-inhibitors. Table S2. The searching space of the Bayesian optimization and the optimal hyper-parameters determined by the Bayesian optimization for all the studied models; Table S3. The detailed descriptions of the 65 representative descriptors chosen by rfSA; Table S4. The detailed descriptions of the 79 representative fingerprints chosen by rfSA; Table S5. The detailed descriptions of the misclassified molecules given by the SVM mode1.
DOI: 10.6084/m9.figshare.11946003.v1
title: Additional file 1 of ADMET evaluation in drug discovery. 20. Prediction of breast cancer resistance protein inhibition through machine learning

description: Additional file 1: Table S1. The detailed descriptions of the final dataset containing 1098 BCRP inhibitors and 1701 BCRP non-inhibitors. Table S2. The searching space of the Bayesian optimization and the optimal hyper-parameters determined by the Bayesian optimization for all the studied models; Table S3. The detailed descriptions of the 65 representative descriptors chosen by rfSA; Table S4. The detailed descriptions of the 79 representative fingerprints chosen by rfSA; Table S5. The detailed descriptions of the misclassified molecules given by the SVM mode1.
DOI: 10.6084/m9.figshare.11946012
title: Additional file 2 of ADMET evaluation in drug discovery. 20. Prediction of breast cancer resistance protein inhibition through machine learning

description: Additional file 2. The R source code that implements the workflow.
DOI: 10.6084/m9.figshare.11946012.v1
title: Additional file 2 of ADMET evaluation in drug discovery. 20. Prediction of breast cancer resistance protein inhibition through machine learning

description: Additional file 2. The R source code that implements the workflow.
DOI: 10.6084/m9.figshare.8276012
title: Additional file 20: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S12. Homologs of lipopolysaccharide biosynthesis genes in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.8276012.v1
title: Additional file 20: of Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features

description: Table S12. Homologs of lipopolysaccharide biosynthesis genes in P. carotovorum subsp. brasiliense SX309 and other Pectobacterium spp. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.21907540
title: Synthesis and Biological Activity of Trolox Amide Derivatives

description: Abstract A series of Trolox amide derivatives were synthesized by modifying the carboxyl groups of Trolox. Thirty target compounds were obtained and characterized through nuclear magnetic resonance and mass spectrometry. Trolox derivatives were employed to explore the potential structure-antioxidant activity relationships. The antioxidant activities of these compounds were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP) and hydroxyl radical assays. DPPH scavenging activity test results illustrated that compounds exhibited scavenging activities similar to L-ascorbic acid and Trolox, with compounds 14a, 18a, 24a and 26a in particular exhibiting higher scavenging activities than L-ascorbic acid. The results demonstrated that compounds displayed ABTS scavenging activities similar to L-ascorbic acid and Trolox, with compounds 26a and 29a in particular having potency twofold higher. FRAP assay results indicated that compounds 11a, 19a, 25a, 29a and 30a had activity similar to Trolox. The results revealed that compounds 6a and 19a had similarly high hydroxyl radical-scavenging activities as Trolox. The results of α-glucosidase experiments uncovered that compounds 10a, 25a, 28a and 29a had excellent inhibitory activity, which was similar to that of acarbose and different from Trolox. The results of acetylcholinesterase and butyrylcholinesterase experiments demonstrated that some compounds had weak anticholinesterase activities. 26a and 29a are important Trolox derivatives with better biological activity profiles and deserve further study.