cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16600217.v1
title: LncRNA MALAT1-deficiency restrains lipopolysaccharide (LPS)-induced pyroptotic cell death and inflammation in HK-2 cells by releasing microRNA-135b-5p

description: Long non-coding RNAs (LncRNAs) participate in the regulation of chronic kidney disease (CKD), and acute kidney injury (AKI) is identified as an important risk factor for CKD. This study investigated the involvement of a novel LncRNA MALAT1 in regulating lipopolysaccharide (LPS)-induced cell pyroptosis and inflammation in the human renal tubular epithelial HK-2 cells. Here, the HK-2 cells were subjected to LPS (2 μg/mL) treatment to establish cellular AKI models <i>in vitro</i>, and we validated that LPS triggered NLRP3-mediated pyroptotic cell death, promoted cell apoptosis and inflammation-associated cytokines secretion to induce HK-2 cell injury. Then, a novel LncRNA MALAT1/miRNA (miRNA)-135b-5p axis was verified to rescue cell viability in LPS treated HK-2 cells by targeting NLRP3. Mechanistically, miRNA-135b-5p bound to LncRNA MALAT1, and LncRNA MALAT1 positively regulated NLRP3 through acting as RNA sponger for miRNA-135b-5p. Further gain- and loss-of-function experiments evidenced that both LncRNA MALAT1 ablation and miRNA-135b-5p overexpression reversed LPS-induced cell pyroptosis, apoptosis, and inflammation in the HK-2 cells, and the protective effects of LncRNA MALAT1 knock-down on LPS-treated HK-2 cells were abrogated by silencing miRNA-135b-5p. In general, our study firstly investigated the role of the LncRNA MALAT1/ miRNA-135b-5p/NLRP3 signaling cascade in regulating LPS-induced inflammatory death in HK-2 cells.
DOI: 10.6084/m9.figshare.13978724.v1
title: Additional file 2 of Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways

description: Additional file 2: Table S2. Top 10 significantly down-regulated and up-regulated circRNAs in UM tissues ranked by FC
DOI: 10.6084/m9.figshare.19746086.v1
title: Additional file 4 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 4: Table S1. The statistics results of sequencing data and reference genome reads in YO-A, YO-F, and YO-P samples.
DOI: 10.6084/m9.figshare.19746089.v1
title: Additional file 5 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 5: Table S2. The annotation of peaks on the genome including the detailed location  and length information in YO-A, YO-F, and YO-P samples.
DOI: 10.6084/m9.figshare.19746095
title: Additional file 7 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 7: Table S4. The combined analysis results of MERIP-seq and RNA-seq in YO-FvsA, YO-FvsP, and YO-PvsA groups.
DOI: 10.6084/m9.figshare.19746092
title: Additional file 6 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 6: Table S3. The differential m6A peaks and annotations were screened in YO-FvsA, YO-FvsP, and YO-PvsA groups.
DOI: 10.6084/m9.figshare.13199043
title: Additional file 6 of The Transcriptome of Cunninghamia lanceolata male/female cone reveal the association between MIKC MADS-box genes and reproductive organs development

description: Additional file 6 Table S6. List of the primers used for qRT-PCR.
DOI: 10.6084/m9.figshare.20267333
title: Additional file 11 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 11. Table S10. In the SRMT overexpressing lines, the genes with expression level in the top 700 were related to ABA, drought and salt stress, etc.
DOI: 10.6084/m9.figshare.13199043.v1
title: Additional file 6 of The Transcriptome of Cunninghamia lanceolata male/female cone reveal the association between MIKC MADS-box genes and reproductive organs development

description: Additional file 6 Table S6. List of the primers used for qRT-PCR.
DOI: 10.6084/m9.figshare.20267339
title: Additional file 13 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 13. Table S12. The primers in this study.
DOI: 10.6084/m9.figshare.20267354.v1
title: Additional file 3 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 3. Table S2. The differential expression genes with NaCl treatment compared to control.
DOI: 10.6084/m9.figshare.20267360
title: Additional file 5 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 5. Table S4. The genes co-expressed with PtoRD26.
DOI: 10.6084/m9.figshare.17124644
title: Additional file 2 of Identification of genes related to tipburn resistance in Chinese cabbage and preliminary exploration of its molecular mechanism

description: Additional file 2: Figure S1. Principal component analysis of all genes in tipburn sensitive samples and tipburn resistant samples. Figure S2. FPKM and qRT-PCR values of 21 tipburn related protein genes.
DOI: 10.5281/zenodo.10577531
title: BRAZILIAN JUDICIARY TECHNOLOGICAL TRANSFORMATION

description: The article aims to analyze the impact of the Brazilian National Council of Justice (CNJ) resolutions into the digital transformation of the judiciary, providing reflections on the need for this in light of the rapid changes in social and economic dynamics that have taken place in recent decades, including technological disruptions. For that, a brief contextualization of the Brazilian Judiciary will be carried out, followed by the presentation of the resolutions published by the CNJ and its repercussion in the construction of the so-called Judiciary 4.0, in an adaptation of the millenary institution to contemporary society and new times, marked by the concepts of online Courts and Digital Justice.
DOI: 10.5281/zenodo.10577532
title: BRAZILIAN JUDICIARY TECHNOLOGICAL TRANSFORMATION

description: The article aims to analyze the impact of the Brazilian National Council of Justice (CNJ) resolutions into the digital transformation of the judiciary, providing reflections on the need for this in light of the rapid changes in social and economic dynamics that have taken place in recent decades, including technological disruptions. For that, a brief contextualization of the Brazilian Judiciary will be carried out, followed by the presentation of the resolutions published by the CNJ and its repercussion in the construction of the so-called Judiciary 4.0, in an adaptation of the millenary institution to contemporary society and new times, marked by the concepts of online Courts and Digital Justice.
DOI: 10.6084/m9.figshare.11357588.v1
title: Late Mesozoic tectonic evolution of the central Bangong–Nujiang Suture Zone, central Tibetan Plateau

description: The Bangong–Nujiang Suture Zone (BNSZ), located in the central Tibetan Plateau, experienced a Late Mesozoic transition from oceanic closure to continent–continent collision. Based on sandstone-composition analyses, U-Pb detrital-zircon dating and structural observations, we determined that this transition occurred coeval with the accretion of the Lhasa Terrane to Eurasia. According to our newly observed stratigraphic and geochronological data, we conclude the following: (1) the Upper Triassic-Lower Jurassic Muggar Gangri Group was mainly derived from the Qiangtang Terrane; (2) the Shamuluo Formation composed of Upper Jurassic-Lower Cretaceous shallow marine strata was sourced from both the Qiangtang Terrane and recycled Muggar Gangri Group; (3) the Lower Cretaceous (~125–110 Ma) Duoni Formation shows both Lhasa and Qiangtang detrital zircon fingerprints, indicating closure of the Bangong–Nujiang Ocean at ~120 Ma; and (4) the Upper Cretaceous Abushan Formation is a suite of intramontane molasse deposited after the Qiangtang–Lhasa collision. Therefore, these sedimentary strata record the transition from oceanic closure to continent–continent collision from 125 to 90 Ma within the central BNSZ. Moreover, based on relationships among strata distributions and thrust locations, we propose that thrust movements propagated southward during this transition and controlled sedimentary basin deposition. The Late Mesozoic tectonic transition within the BNSZ occurred well before the India-Asia collision and hence profoundly influenced the Cenozoic formation of the Tibetan Plateau.
DOI: 10.6084/m9.figshare.20267363
title: Additional file 6 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 6. Table S5. The genes involved in salt, water stress and ABA in the co-expression analysis.
DOI: 10.6084/m9.figshare.6638873.v1
title: Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

description: Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined the DNA methylation signatures in transcriptomically pre-classified GSC and GBM bulk tumors subtypes. We hypothesized that these DNA methylation signatures correlate with gene expression and are uniquely associated either with only GSCs or only GBM bulk tumors. Additional methylation signatures may be commonly associated with both GSCs and GBM bulk tumors, i.e., common to non-stem-like and stem-like tumor cell populations and correlating with the clinical prognosis of glioma patients. We analyzed Illumina 450K methylation array and expression data from a panel of 23 patient-derived GSCs. We referenced these results with The Cancer Genome Atlas (TCGA) GBM datasets to generate methylomic and transcriptomic signatures for GSCs and GBM bulk tumors of each transcriptomically pre-defined tumor subtype. Survival analyses were carried out for these signature genes using publicly available datasets, including from TCGA. We report that DNA methylation signatures in proneural and mesenchymal tumor subtypes are either unique to GSCs, unique to GBM bulk tumors, or common to both. Further, dysregulated DNA methylation correlates with gene expression and clinical prognoses. Additionally, many previously identified transcriptionally-regulated markers are also dysregulated due to DNA methylation. The subtype-specific DNA methylation signatures described in this study could be useful for refining GBM sub-classification, improving prognostic accuracy, and making therapeutic decisions.
DOI: 10.6084/m9.figshare.17124629
title: Additional file 1 of Identification of four hub genes in venous thromboembolism via weighted gene coexpression network analysis

description: Additional file 1. DEGs of GSE19151 and GSE48000.
DOI: 10.6084/m9.figshare.17124647
title: Additional file 3 of Identification of genes related to tipburn resistance in Chinese cabbage and preliminary exploration of its molecular mechanism

description: Additional file 3.
DOI: 10.5281/zenodo.10577496
title: INFILTRATION OF NEW TECHNOLOGIES INTO THE HUNGARIAN EVIDENCE LAW RELATING TO CIVIL CASES

description: The article covers the topic of what challenges the Hungarian evidentiary system has faced in recent years in civil cases, primarily from the direction of information technology. The paper provides a comprehensive overview of the responses received from the legislator and where this did not resolve some issues, what kind of challenge this posed for judicial practice. It also provides a brief description of some legal cases where Hungarian courts responded to IT challenges. It confronts the reader with the problems that are still unsolved or are expected to appear in the near future. In the latter area, it is primarily about the questions raised by artificial intelligence.
DOI: 10.5281/zenodo.10577497
title: INFILTRATION OF NEW TECHNOLOGIES INTO THE HUNGARIAN EVIDENCE LAW RELATING TO CIVIL CASES

description: The article covers the topic of what challenges the Hungarian evidentiary system has faced in recent years in civil cases, primarily from the direction of information technology. The paper provides a comprehensive overview of the responses received from the legislator and where this did not resolve some issues, what kind of challenge this posed for judicial practice. It also provides a brief description of some legal cases where Hungarian courts responded to IT challenges. It confronts the reader with the problems that are still unsolved or are expected to appear in the near future. In the latter area, it is primarily about the questions raised by artificial intelligence.
DOI: 10.6084/m9.figshare.17124820
title: Additional file 2 of Identification of the ferroptosis-related long non-coding RNAs signature to improve the prognosis prediction and immunotherapy response in patients with NSCLC

description: Additional file 2. Supplementary tables.
DOI: 10.6084/m9.figshare.20267363.v1
title: Additional file 6 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 6. Table S5. The genes involved in salt, water stress and ABA in the co-expression analysis.
DOI: 10.5281/zenodo.10577606
title: RUSSIA/UKRAINE MILITARY CONFLICT: DISCUSSING THE MARITIME ELEMENT OF THE CONFRONTATION

description: Within the globalization era, the conduct, resolution, and impact of international conflicts are frequently not limited solely to the belligerent states involved. Conflict influences distant countries and often illustrates the vulnerability of sea access to the security of coastal and landlocked nations, by factoring in that: import/export commodities are impacted; access to vital energy resources is undermined; and/or international resource distribution is threatened. Therefore, the maritime domain (and its military, legal, and commercial components) represents a Russia/Ukraine conflict cornerstone and the epicenter of this analysis. This conflict highlights maritime trade importance and re-establishes the strategic significance of protecting multi-polarity, the “rule of law”, and freedom of the seas within the Black Sea region (BSR), which today represents a very large concentration of power (involving actors like Russia, USA, NATO, EU) and has been the site of ten post-Cold War conflicts. Resultantly, maritime domain objectives and tactical events (on, above, and below the seas) require detailed analysis as hostilities continue, the norms and principles of international law are threatened and/or undermined, and prospective combat end-state(s) are considered. Such will define Russia’s and Ukraine’s future(s), as well as economic-diplomatic stability and the future of rules-based international order across the BSR, which is a vital maritime transport corridor. 

Amidst increasing maritime emphasis, this conflict also illustrates transformational warfighting facets. In addition to troops, ships, and aircraft, modern battlefields now include issues like: Information Warfare outlets; “lawfare”; cyber threats; and adversaries with unprecedented Artificial Intelligence capabilities. The international community must acknowledge these skills yield warfighting capability to nations lacking capacity. As naval warfare equipment and tactics change, protecting sea lanes, preventing maritime hegemony, and upholding the “rule of law”, remain dominant-and are enhanced by globalization.
DOI: 10.5281/zenodo.10577607
title: RUSSIA/UKRAINE MILITARY CONFLICT: DISCUSSING THE MARITIME ELEMENT OF THE CONFRONTATION

description: Within the globalization era, the conduct, resolution, and impact of international conflicts are frequently not limited solely to the belligerent states involved. Conflict influences distant countries and often illustrates the vulnerability of sea access to the security of coastal and landlocked nations, by factoring in that: import/export commodities are impacted; access to vital energy resources is undermined; and/or international resource distribution is threatened. Therefore, the maritime domain (and its military, legal, and commercial components) represents a Russia/Ukraine conflict cornerstone and the epicenter of this analysis. This conflict highlights maritime trade importance and re-establishes the strategic significance of protecting multi-polarity, the “rule of law”, and freedom of the seas within the Black Sea region (BSR), which today represents a very large concentration of power (involving actors like Russia, USA, NATO, EU) and has been the site of ten post-Cold War conflicts. Resultantly, maritime domain objectives and tactical events (on, above, and below the seas) require detailed analysis as hostilities continue, the norms and principles of international law are threatened and/or undermined, and prospective combat end-state(s) are considered. Such will define Russia’s and Ukraine’s future(s), as well as economic-diplomatic stability and the future of rules-based international order across the BSR, which is a vital maritime transport corridor. 

Amidst increasing maritime emphasis, this conflict also illustrates transformational warfighting facets. In addition to troops, ships, and aircraft, modern battlefields now include issues like: Information Warfare outlets; “lawfare”; cyber threats; and adversaries with unprecedented Artificial Intelligence capabilities. The international community must acknowledge these skills yield warfighting capability to nations lacking capacity. As naval warfare equipment and tactics change, protecting sea lanes, preventing maritime hegemony, and upholding the “rule of law”, remain dominant-and are enhanced by globalization.
DOI: 10.6084/m9.figshare.17124656.v1
title: Additional file 1 of Pregnancy-associated thrombotic thrombocytopenic purpura complicated by Sjögren’s syndrome and non-neutralising antibodies to ADAMTS13: a case report

description: Additional file 1.
DOI: 10.6084/m9.figshare.19221982
title: Inflammatory Bowel disease promote oral cancer and pharyngeal cancer: new evidence of Mendelian randomization

description: Evidence from observational studies shows that inflammatory bowel disease (IBD) [comprising ulcerative colitis (UC) and Crohn’s disease (CD)] is a risk factor to Oral cavity and pharyngeal cancer (OC&PC) [comprising Oral cavity cancer (OCC) and Oropharyngeal cancer (OPC)], but it is unclear whether these diseases have potential causality. We aimed to explore the causal relationship between IBD and OC&PC. A mendelian randomized (MR) study was performed to estimate the causal relationship between IBD and OC&PC. The potential causal relationship was statistically significant between IBD and OCC (OR = 1.14, 95% confidence interval (CI): 1.02–1.27, <i>p</i> = .02), UC and OCC (OR = 1.13, 95% CI: 1.01–1.27, <i>p</i> = .03), respectively. There was a universal null effect of IBD on OC&PC (IBD: OR = 1.01, 95%CI: 0.93–1.10, <i>p</i> = .74; UC: OR = 1.00, 95%CI: 0.92–1.10, <i>p</i> = .94; CD: OR = 1.02, 95%CI: 0.94–1.09, <i>p</i> = .69), and IBD on OPC (IBD: OR = 0.93, 95%CI: 0.81–1.06, <i>p</i> = 0.26; UC: OR = 0.90, 95%CI: 0.79–1.03, <i>p</i> = .12; CD: OR = 1.04, 95%CI: 0.94–1.15, <i>p</i> = .44). MR analyses support new evidence indicating there may be a positive causal effect of IBD (including UC) on OCC. Further investigation of the potential biological mechanisms is necessary.
DOI: 10.6084/m9.figshare.19746113
title: Additional file 3 of Combination of serological biomarkers and clinical features to predict mucosal healing in Crohn’s disease: a multicenter cohort study

description: Additional file 3. Excel 3. General information of the patients.
DOI: 10.6084/m9.figshare.19746086
title: Additional file 4 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 4: Table S1. The statistics results of sequencing data and reference genome reads in YO-A, YO-F, and YO-P samples.
DOI: 10.6084/m9.figshare.19746098
title: Additional file 8 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 8: Table S5. Primer sequence of target gene in qPCR experiment.
DOI: 10.6084/m9.figshare.11357588
title: Late Mesozoic tectonic evolution of the central Bangong–Nujiang Suture Zone, central Tibetan Plateau

description: The Bangong–Nujiang Suture Zone (BNSZ), located in the central Tibetan Plateau, experienced a Late Mesozoic transition from oceanic closure to continent–continent collision. Based on sandstone-composition analyses, U-Pb detrital-zircon dating and structural observations, we determined that this transition occurred coeval with the accretion of the Lhasa Terrane to Eurasia. According to our newly observed stratigraphic and geochronological data, we conclude the following: (1) the Upper Triassic-Lower Jurassic Muggar Gangri Group was mainly derived from the Qiangtang Terrane; (2) the Shamuluo Formation composed of Upper Jurassic-Lower Cretaceous shallow marine strata was sourced from both the Qiangtang Terrane and recycled Muggar Gangri Group; (3) the Lower Cretaceous (~125–110 Ma) Duoni Formation shows both Lhasa and Qiangtang detrital zircon fingerprints, indicating closure of the Bangong–Nujiang Ocean at ~120 Ma; and (4) the Upper Cretaceous Abushan Formation is a suite of intramontane molasse deposited after the Qiangtang–Lhasa collision. Therefore, these sedimentary strata record the transition from oceanic closure to continent–continent collision from 125 to 90 Ma within the central BNSZ. Moreover, based on relationships among strata distributions and thrust locations, we propose that thrust movements propagated southward during this transition and controlled sedimentary basin deposition. The Late Mesozoic tectonic transition within the BNSZ occurred well before the India-Asia collision and hence profoundly influenced the Cenozoic formation of the Tibetan Plateau.
DOI: 10.6084/m9.figshare.19746089
title: Additional file 5 of The transcriptome-wide N6-methyladenosine (m6A) map profiling reveals the regulatory role of m6A in the yak ovary

description: Additional file 5: Table S2. The annotation of peaks on the genome including the detailed location  and length information in YO-A, YO-F, and YO-P samples.
DOI: 10.6084/m9.figshare.20267336.v1
title: Additional file 12 of PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

description: Additional file 12. Table S11. The potential interacting proteins of SRMT from Y2H screening assay.
DOI: 10.25549/usctheses-ouc113968213
title: What university equity and diversity leaders are doing to deal with issues of equity, access, and inclusion
DOI: 10.25549/usctheses-ouc113968212
title: Exploring the barriers that contribute to the underrepresentation of Black women in C-suite roles in corporate America
DOI: 10.25549/usctheses-ouc113967454
title: Fetal brain development is impacted by placental lesions in pregnancies complicated by congenital heart disease
DOI: 10.25549/usctheses-ouc113967452
title: Robust and adaptive algorithm design in online learning: regularization, exploration, and aggregation
DOI: 10.25549/usctheses-ouc113956537
title: The queen of courtly dance: music and choreography of the bassadanza and basse danse
DOI: 10.25549/usctheses-ouc113956482
title: Imaging cortical noradrenergic dynamics with genetically-engineered fluorescent indicators
DOI: 10.25549/usctheses-ouc113956479
title: Association of chronic obstructive pulmonary disease and mortality following thoracic and complex endovascular aortic repair: a retrospective cohort study
DOI: 10.25549/usctheses-ouc113956481
title: Foundation models for embodied AI
DOI: 10.25549/usctheses-ouc113956475
title: Post-secondary distance education: cultivating a sense of belonging through teaching presence
DOI: 10.25549/usctheses-ouc113953638
title: Towards generalized event understanding in text via generative models