cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/105268
title: Meteorological Station data collected during research cruise MGLN29MV using a SIO MET-System instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17028/rd.lboro.7455221
title: Supplementary information files for article: 'Entanglement dynamics in ultra-high molecular weight polyethylene as revealed by dielectric spectroscopy'

description: Supplementary information files for article: 'Entanglement dynamics in ultra-high molecular weight polyethylene as revealed by dielectric spectroscopy'.<br>Abstract: With the help of Broadband Dielectric Spectroscopy, it has been possible to study the molecular dynamics of disentangled Ultra High Molecular Weight Polyethylene in a wide temperature and frequency range. Catalytic ashes of aluminum oxide act as dielectric probes, allowing the identification of five different processes: an αc-process due to movements in the crystalline phase, two γ-processes attributed to amorphous chain portions close to the crystalline lamellae, and two β-processes that we have attributed to the disentangled and entangled amorphous phases. The entanglement formation has been followed by isothermal runs and a model that predicts the energy spent to form entanglements as a function of time and temperature is thereby proposed. This model allowed us to calculate the associated activation energy of the entanglement process.Our work advances further the understanding of entanglement dynamics of ultra-high molecular weight polymers, and the proposed model could prove useful to describe other similar processes such as cross-linking.In the supporting information provided for this article, the comparison between the loss permittivity and loss modulus as a function of frequency varying the temperature, the superposition lines of the Havriliak-Negami fits against the experimental data for all the measured temperatures and the tables for the fittings are present.<br>
DOI: 10.7284/104915
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise MGLN30MV using a Hawaii UHDAS instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17028/rd.lboro.7455221.v1
title: Supplementary information files for article: 'Entanglement dynamics in ultra-high molecular weight polyethylene as revealed by dielectric spectroscopy'

description: Supplementary information files for article: 'Entanglement dynamics in ultra-high molecular weight polyethylene as revealed by dielectric spectroscopy'.<br>Abstract: With the help of Broadband Dielectric Spectroscopy, it has been possible to study the molecular dynamics of disentangled Ultra High Molecular Weight Polyethylene in a wide temperature and frequency range. Catalytic ashes of aluminum oxide act as dielectric probes, allowing the identification of five different processes: an αc-process due to movements in the crystalline phase, two γ-processes attributed to amorphous chain portions close to the crystalline lamellae, and two β-processes that we have attributed to the disentangled and entangled amorphous phases. The entanglement formation has been followed by isothermal runs and a model that predicts the energy spent to form entanglements as a function of time and temperature is thereby proposed. This model allowed us to calculate the associated activation energy of the entanglement process.Our work advances further the understanding of entanglement dynamics of ultra-high molecular weight polymers, and the proposed model could prove useful to describe other similar processes such as cross-linking.In the supporting information provided for this article, the comparison between the loss permittivity and loss modulus as a function of frequency varying the temperature, the superposition lines of the Havriliak-Negami fits against the experimental data for all the measured temperatures and the tables for the fittings are present.<br>
DOI: 10.6084/m9.figshare.7455200
title: OLA POST (24h) EXP 15 s2 y resumenes ppt

description: Olaparib partially reverts EMT
DOI: 10.6084/m9.figshare.7455200.v1
title: OLA POST (24h) EXP 15 s2 y resumenes ppt

description: Olaparib partially reverts EMT
DOI: 10.7284/104911
title: Expendable Probe data collected during research cruise MGLN30MV using a Sippican MK21 instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7455110
title: Supplementary Material for: Effects of Enteral Immunonutrition in Patients Undergoing Pancreaticoduodenectomy: A Meta-Analysis of Randomized Controlled Trials

description: <b><i>Background:</i></b> The effect of enteral immunonutrition (EIN) in patients undergoing pancreaticoduodenectomy (PD) is still doubtful. This meta-analysis aimed to assess the impact of EIN on postoperative clinical outcomes for patients undergoing PD. <b><i>Methods:</i></b> A literature search was carried out to identify all of the randomized controlled trials (RCTs) concerning the use of EIN for PD. Data collection ended on April 1, 2018. Pooled risk ratios (RRs) and the mean difference (MD) with a 95% CI were calculated using fixed effects or random effects models. The analyses were performed with RevMan 5.3.5. <b><i>Results:</i></b> Four RCTs with a total of 299 patients were included. Immunonutrition reduced the incidence of postoperative infectious complications (RR 0.58, 95% CI 0.37–0.92; <i>p</i> = 0.02) and shortened the length of hospital stay (MD –1.79, 95% CI –3.40 to 0.18; <i>p</i> = 0.03). Conversely, there were no significant differences in the incidence of overall postoperative complications (RR 0.81, 95% CI 0.62–1.05; <i>p</i> = 0.11), non-infectious complications (RR 0.94, 95% CI 0.69–1.28; <i>p</i> = 0.70) and postoperative mortality (RR 2.43, 95% CI 0.37–16.10; <i>p</i> = 0.36). <b><i>Conclusions:</i></b> EIN reduced postoperative infectious complications and shortened the length of the hospital stay; immunonutrition should be encouraged in patients undergoing PD.
DOI: 10.7284/104909
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGLN30MV using a Furuno GP-90D instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7455071
title: 3D printing .stl files (ready for slicing & printing)

description: 3D printing .stl files (ready for slicing & printing)
DOI: 10.6084/m9.figshare.7455065
title: 3D printing models (solvespace)

description: 3D models (solvespace)
DOI: 10.7284/104910
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGLN30MV using a Trimble NT-200D instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7455065.v1
title: 3D printing models (solvespace)

description: 3D models (solvespace)
DOI: 10.7284/104918
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGLN30MV using a Ashtech ADU2 instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/104913
title: Gravimeter data collected during research cruise MGLN30MV using a Bell BGM-3 instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17632/r5tfvj35p3.4
title: Data for: Adolescent Aggression and Violent Video Games: The role of moral disengagement and parental rearing patterns

description: Data for: Adolescent Aggression and Violent Video Games: The role of moral disengagement and parental rearing patterns boys=1, girls=2.
DOI: 10.6084/m9.figshare.7455029
title: Supplementary Material for: Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study

description: <b><i>Background:</i></b> There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. <b><i>Methods:</i></b> The study population comprised 389 consecutive patients who received mechanical ventilation for at least 24 h and those admitted to the ICU for &gt; 72 h in 13 hospitals. The primary outcomes were caloric and protein intake in ICU on days 3 and 7, and at ICU discharge. The secondary outcome was the impact of nutritional management and rehabilitation on physical status at ICU discharge. We defined good physical status as more than end sitting and poor physical status as bed rest and sitting. We divided the participants into 2 groups, namely, the good physical status group (Good group) and poor physical status group (Poor group) for analysis of the secondary outcome. Data were expressed as median (interquartile range). <b><i>Results:</i></b> The median amount of caloric intake on days 3 and 7, and at ICU discharge via enteral and parenteral routes were 8.4 (3.1–15.6), 14.9 (7.5–22.0), and 11.2 (2.5–19.1) kcal/kg/day, respectively. The median amount of protein intake on days 3 and 7, and at ICU discharge were 0.2 (0–0.5), 0.4 (0.1–0.8), and 0.3 (0–0.7) g/kg/day, respectively. The amount of caloric intake on day 3 in the Poor group was significantly higher than that of the Good group (10.1 [5.8, 16.2] vs. 5.2 [1.9, 12.4] kcal/kg/day, <i>p</i> &lt; 0.001). The proportion of patients who were received rehabilitation in ICU in the Good group was significantly higher than that of the Poor group (92 vs. 63%, <i>p</i> &lt; 0.001). The multivariate analysis revealed that caloric intake on day 3 and rehabilitation in ICU were considered independent factors that affect physical status (OR 1.19; 95% CI 1.05–1.34; <i>p</i> = 0.005 and OR 0.07; 95% CI 0.01–0.34; <i>p</i> = 0.001). <b><i>Conclusions:</i></b> The caloric and protein intakes in Japanese ICUs were 15 kcal/kg/day and 0.4 g/kg/day, respectively. In addition, critically ill patients might benefit from low caloric intake (less than 10 kcal/kg/day) until day 3 and rehabilitation during ICU stay.
DOI: 10.7284/105003
title: Magnetometer data collected during research cruise MGLN30MV using a Marine Magnetics SeaSPY instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7454945
title: Cement-related CO2 emissions in China

description: This data set provides the production and consumption of the cement industry in China, as well as its energy consumption and emissions.
DOI: 10.7284/105400
title: Magnetometer data collected during research cruise MGLN30MV using a Marine Magnetics SeaSPY instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17633/rd.brunel.7454888
title: Engagement of general practitioners in falls prevention assessment and referral to allied health practitioners - a cross-sectional survey

description: This project used a cross-sectional survey method to gather information from GPs practicing in England. As the GP system operates differently in Scotland, Wales and Northern Ireland, these GPs were not included in the study. The survey was developed based on literature related to GP practice in falls prevention, current falls prevention clinical guidelines, completed Australian studies, and the results of pilot on-line survey, in conjunction with feedback from a group of GPs and a focus group of older people. All 211 Community Care Groups (CCGs) in NHS England were approached to support the survey, and 4 CCGs opted out. The survey was provided as both a paper survey to 4000 randomly selected GPs and a further 3,200 GPs were invited to participate via an online version of the same survey (using the Bristol Online Survey software). As advised by GP advisors we sent letter to GP practice managers and included an evidence-based invitation letter (as well as participant information sheet) for GPs, in order to enhance response rate. Survey topics included the perceptions, knowledge and routine practice of GPs in relation to identifying, screening and assessing falls risks in their people, their falls management and referral practices, and barriers and facilitators to them effectively preventing falls in their older people. The study has contributed to the methodological debate about paper versus online survey response rates. In this study the response rate was equally poor for both versions. Response rate was seemingly higher of GPs from CCGs who had actively endorsed participation in the study. · Letter to GP practice managers · Evidence-based letter to GPs · Participant Information sheet · Paper copy of Survey · Spreadsheet of raw data – complete set, paper, online · Publication reference: McIntyre A, Mackenzie L, Harvey M (2018) Engagement of general practitioners in falls prevention and referral to occupational therapists. British Journal of Occupational Therapy, (online) · Copy of presentation given at Royal College of Occupational Therapists’ 2017 conference <b></b><i></i><sub></sub><sup></sup><br>
DOI: 10.17633/rd.brunel.7454888.v1
title: Engagement of general practitioners in falls prevention assessment and referral to allied health practitioners - a cross-sectional survey

description: This project used a cross-sectional survey method to gather information from GPs practicing in England. As the GP system operates differently in Scotland, Wales and Northern Ireland, these GPs were not included in the study. The survey was developed based on literature related to GP practice in falls prevention, current falls prevention clinical guidelines, completed Australian studies, and the results of pilot on-line survey, in conjunction with feedback from a group of GPs and a focus group of older people. All 211 Community Care Groups (CCGs) in NHS England were approached to support the survey, and 4 CCGs opted out. The survey was provided as both a paper survey to 4000 randomly selected GPs and a further 3,200 GPs were invited to participate via an online version of the same survey (using the Bristol Online Survey software). As advised by GP advisors we sent letter to GP practice managers and included an evidence-based invitation letter (as well as participant information sheet) for GPs, in order to enhance response rate. Survey topics included the perceptions, knowledge and routine practice of GPs in relation to identifying, screening and assessing falls risks in their people, their falls management and referral practices, and barriers and facilitators to them effectively preventing falls in their older people. The study has contributed to the methodological debate about paper versus online survey response rates. In this study the response rate was equally poor for both versions. Response rate was seemingly higher of GPs from CCGs who had actively endorsed participation in the study. · Letter to GP practice managers · Evidence-based letter to GPs · Participant Information sheet · Paper copy of Survey · Spreadsheet of raw data – complete set, paper, online · Publication reference: McIntyre A, Mackenzie L, Harvey M (2018) Engagement of general practitioners in falls prevention and referral to occupational therapists. British Journal of Occupational Therapy, (online) · Copy of presentation given at Royal College of Occupational Therapists’ 2017 conference <b></b><i></i><sub></sub><sup></sup><br>
DOI: 10.7284/104917
title: Meteorological Station data collected during research cruise MGLN30MV using a SIO MET-System instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7454882
title: Supplementary Material for: Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis

description: <b><i>Background/Aims:</i></b> Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as well as urinary soluble CD163, could potentially serve as a biomarker of ongoing glomerular injury. <b><i>Methods:</i></b> To test that idea, we collected urine samples from 37 patients with glomerular disease; purified the urinary EVs; characterized them using Nanosight, western blotting, and immunoelectron microscopy; and determined FSP1 and soluble CD163 levels using enzyme-linked immunosorbent assays. <b><i>Results:</i></b> Deemed to be mainly exosomes based on their size distribution, the EVs in urine contained FSP1, and a portion of the FSP1-positive vesicles was also positive for podocalyxin. FSP1 levels in urinary EVs were (1) positively correlated with rates of biopsy-proven cellular crescent formation (<i>r</i> = 0.562, <i>p</i> &lt; 0.001) and total crescent formation (<i>r</i> = 0.448, <i>p</i> = 0.005) among total glomeruli; (2) significantly higher in patients with cellular crescents affecting 20% or more of their glomeruli than in those with fewer affected glomeruli (<i>p</i> = 0.003); and (3) significantly decreased after glucocorticoid and immunosuppressant therapy (<i>p</i> &lt; 0.05). A positive correlation between FSP1 levels in urinary EVs and urinary soluble CD163 levels was confirmed (<i>r</i> = 0.367, <i>p</i> &lt; 0.05). <b><i>Conclusion:</i></b> These data suggest that a portion of urinary FSP1 is secreted as EVs originating from podocytes, and that FSP1 levels reflect active and ongoing glomerular injury and disease activity, such as cellular crescent formation.
DOI: 10.7284/104914
title: Multibeam Echosounder data collected during research cruise MGLN30MV using a Kongsberg EM120 instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/104998
title: Singlebeam Echosounder data collected during research cruise MGLN30MV using a Knudsen 320B/R instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/104920
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise MGLN31MV using a Hawaii UHDAS instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105000
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGLN31MV using a Furuno GP-90D instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17028/rd.lboro.7454804
title: Supplementary information files for article: 'Centralised versus decentralised manufacturing and the delivery of healthcare products: a United Kingdom exemplar'

description: Supplementary information files for article: 'Centralised versus decentralised manufacturing and the delivery of healthcare products: a United Kingdom exemplar'. BACKGROUND. The cell and gene therapy (CGT) field is at a critical juncture. Clinical successes have underpinned the requirement for developing manufacturing capacity suited to patient-specific therapies that can satisfy the eventual demand post-launch. Decentralised or ‘redistributed’ manufacturing divides manufacturing capacity across geographic regions, promising local, responsive manufacturing, customised to the end user, and is an attractive solution to overcome challenges facing the CGT manufacturing chain.METHODS. A study was undertaken building on previous, so far unpublished, semi-structured interviews with key opinion leaders in advanced therapy research, manufacturing and clinical practice. The qualitative findings were applied to construct a cost of goods model that permitted the cost impact of regional siting to be combined with variable and fixed costs of manufacture of a mesenchymal stromal cell product.RESULTS. Using the United Kingdom as an exemplar, cost disparities between regions were examined. Per patient dose costs of ~£1,800 per 75,000,000 cells were observed. Financial savings from situating the facility outside of London allow 25–41 additional staff or 24–35 extra manufacturing vessels to be employed. Decentralised quality control to mitigate site-to-site variation was examined. Partial decentralisation of quality control was observed to be financially possible and an attractive option for facilitating release ‘at risk’.DISCUSSION. There are important challenges that obstruct the easy adoption of decentralised manufacturing that have the potential to undermine the market success of otherwise promising products. By using the United Kingdom as an exemplar, the modelled data provide a framework to inform similar regional policy considerations across other global territories.
DOI: 10.17028/rd.lboro.7454804.v1
title: Supplementary information files for article: 'Centralised versus decentralised manufacturing and the delivery of healthcare products: a United Kingdom exemplar'

description: Supplementary information files for article: 'Centralised versus decentralised manufacturing and the delivery of healthcare products: a United Kingdom exemplar'. BACKGROUND. The cell and gene therapy (CGT) field is at a critical juncture. Clinical successes have underpinned the requirement for developing manufacturing capacity suited to patient-specific therapies that can satisfy the eventual demand post-launch. Decentralised or ‘redistributed’ manufacturing divides manufacturing capacity across geographic regions, promising local, responsive manufacturing, customised to the end user, and is an attractive solution to overcome challenges facing the CGT manufacturing chain.METHODS. A study was undertaken building on previous, so far unpublished, semi-structured interviews with key opinion leaders in advanced therapy research, manufacturing and clinical practice. The qualitative findings were applied to construct a cost of goods model that permitted the cost impact of regional siting to be combined with variable and fixed costs of manufacture of a mesenchymal stromal cell product.RESULTS. Using the United Kingdom as an exemplar, cost disparities between regions were examined. Per patient dose costs of ~£1,800 per 75,000,000 cells were observed. Financial savings from situating the facility outside of London allow 25–41 additional staff or 24–35 extra manufacturing vessels to be employed. Decentralised quality control to mitigate site-to-site variation was examined. Partial decentralisation of quality control was observed to be financially possible and an attractive option for facilitating release ‘at risk’.DISCUSSION. There are important challenges that obstruct the easy adoption of decentralised manufacturing that have the potential to undermine the market success of otherwise promising products. By using the United Kingdom as an exemplar, the modelled data provide a framework to inform similar regional policy considerations across other global territories.
DOI: 10.7284/105001
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGLN31MV using a Trimble NT-200D instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/105002
title: GNSS (Global Navigation Satellite System) data collected during research cruise MGLN31MV using a Ashtech ADU2 instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/104922
title: Meteorological Station data collected during research cruise MGLN31MV using a SIO MET-System instrument system onboard the platform RV Melville

description: Original (unprocessed) data collected during a Field_expedition