cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7048292
title: Effects of periodic forcing on a Paleoclimate delay model - Supplementary material

description: Supplementary material for manuscript:<br>C. Quinn, J. Sieber, A. v. d. Heydt, <b>Effects of periodic forcing on a Paleoclimate delay model</b><br>arXiv:1808.02310<br>Contents:<br><b>heatmap_traj_quasiper.mp4 (</b>Animation)An animation of the comparison between trajectories in the bistable region (blue) and reference trajectories outside of the bistable region with same forcing strength (red).<br><b>U_basin_155.mp4 (</b>Animation)An animation of the moving basin of attraction for different forcing strengths of the periodic forcing.<br><b>Phi_basin_145.mp4</b> (Animation)An animation of the moving basin of attraction for different phases of the periodic forcing.<br><b>SupplementaryDescription.pdf </b> (PDF)Description of how one can modify the search circle (SC) algorithm for stable manifolds for maps.<br><b>matlabdemo.zip</b> (Matlab script)An example Matlab code to compute the stable manifold of saddle periodic orbit using implicit equation-free reduction.
DOI: 10.6084/m9.figshare.7048154
title: Inverse Properties in Neutrosophic Triplet Loop and Their Application to Cryptography

description: A generalized group is an algebraic structure which has a deep physical background in the unified gauge theory and has direct relation with isotopies. Mathematicians and physicists have been trying to construct a suitable unified theory for twistor theory, isotopies theory, and so on.
DOI: 10.6084/m9.figshare.7048154.v1
title: Inverse Properties in Neutrosophic Triplet Loop and Their Application to Cryptography

description: A generalized group is an algebraic structure which has a deep physical background in the unified gauge theory and has direct relation with isotopies. Mathematicians and physicists have been trying to construct a suitable unified theory for twistor theory, isotopies theory, and so on.
DOI: 10.6084/m9.figshare.7048145
title: Crassigyrinus NHMUKVPR10000 'banana_shaped piece', 'thoracic rib, centra TIFFs

description: see paper for details:Herbst, E., Hutchinson, J.R. 2018. New insights into the morphology of the Carboniferous tetrapod <i>Crassigyrinus scoticus </i>from computed tomography. Earth and Environmental Science Transactions of the Royal Society of Edinburgh, published online. https://doi.org/10.1017/S1755691018000804 <br>
DOI: 10.6084/m9.figshare.7048145.v1
title: Crassigyrinus NHMUKVPR10000 'banana_shaped piece', 'thoracic rib, centra TIFFs

description: see paper for details:Herbst, E., Hutchinson, J.R. 2018. New insights into the morphology of the Carboniferous tetrapod <i>Crassigyrinus scoticus </i>from computed tomography. Earth and Environmental Science Transactions of the Royal Society of Edinburgh, in press.
DOI: 10.6084/m9.figshare.7048145.v2
title: Crassigyrinus NHMUKVPR10000 'banana_shaped piece', 'thoracic rib, centra TIFFs

description: see paper for details:Herbst, E., Hutchinson, J.R. 2018. New insights into the morphology of the Carboniferous tetrapod <i>Crassigyrinus scoticus </i>from computed tomography. Earth and Environmental Science Transactions of the Royal Society of Edinburgh, published online. https://doi.org/10.1017/S1755691018000804 <br>
DOI: 10.6084/m9.figshare.7048136
title: Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis: a retrospective evaluation using Medicare claims

description: <b>Background:</b> Two recent evaluations reported that many cancer chemotherapy patients discontinue pegfilgrastim prophylaxis (PP) following the first cycle, and that these patients have a higher subsequent risk of febrile neutropenia (FN). Such evidence is based principally on the experience of younger adults with private healthcare coverage, and the generalizability of results to elderly Medicare patients is unknown. <b>Methods:</b> A matched-cohort design and data from the Medicare Claims Research Identifiable Files were employed. The source population comprised cancer patients aged ≥65 years who received chemotherapy with intermediate/high-risk for FN and first-cycle PP. From the source population, beginning with the second cycle, all patients who received PP in all previous cycles were identified. From this sub-set, patients who did not receive PP in the cycle of interest (“comparison patients”) were matched to those who received PP in that cycle (“PP patients”); the same process was repeated for subsequent cycles. Odds ratios (OR) for FN (broad and narrow definitions) were estimated using generalized estimating equations. <b>Results:</b> Among 77,616 elderly patients in the source population, 5.3% did not receive second-cycle PP and were matched to those who did. In cycle 2, FN odds were significantly higher among comparison patients vs PP patients when employing the broad definition (OR = 1.9, <i>p</i> p p p p = .060; narrow definition: OR = 1.7, <i>p</i> = .055) were largely comparable. <b>Conclusions:</b> In this large-scale evaluation of elderly Medicare patients who received myelosuppressive chemotherapy and first-cycle PP in recent US clinical practice, FN risk was substantially lower among patients who continued to receive PP in subsequent cycles vs those who discontinued PP.
DOI: 10.6084/m9.figshare.7048136.v1
title: Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis: a retrospective evaluation using Medicare claims

description: <b>Background:</b> Two recent evaluations reported that many cancer chemotherapy patients discontinue pegfilgrastim prophylaxis (PP) following the first cycle, and that these patients have a higher subsequent risk of febrile neutropenia (FN). Such evidence is based principally on the experience of younger adults with private healthcare coverage, and the generalizability of results to elderly Medicare patients is unknown. <b>Methods:</b> A matched-cohort design and data from the Medicare Claims Research Identifiable Files were employed. The source population comprised cancer patients aged ≥65 years who received chemotherapy with intermediate/high-risk for FN and first-cycle PP. From the source population, beginning with the second cycle, all patients who received PP in all previous cycles were identified. From this sub-set, patients who did not receive PP in the cycle of interest (“comparison patients”) were matched to those who received PP in that cycle (“PP patients”); the same process was repeated for subsequent cycles. Odds ratios (OR) for FN (broad and narrow definitions) were estimated using generalized estimating equations. <b>Results:</b> Among 77,616 elderly patients in the source population, 5.3% did not receive second-cycle PP and were matched to those who did. In cycle 2, FN odds were significantly higher among comparison patients vs PP patients when employing the broad definition (OR = 1.9, <i>p</i> p p p p = .060; narrow definition: OR = 1.7, <i>p</i> = .055) were largely comparable. <b>Conclusions:</b> In this large-scale evaluation of elderly Medicare patients who received myelosuppressive chemotherapy and first-cycle PP in recent US clinical practice, FN risk was substantially lower among patients who continued to receive PP in subsequent cycles vs those who discontinued PP.
DOI: 10.6084/m9.figshare.7047695
title: Supplementary Material for: MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma

description: <b><i>Background/Aims:</i></b> Classical Hodgkin lymphoma (cHL) is among the most frequent lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells that escaped from apoptosis. MicroRNAs (miRNAs) play important roles in B-cell maturation and aberrant expression of miRNAs contributes to the pathogenesis of cHL. Our aim was to identify oncogenic miRNAs relevant for growth of cHL using a high-throughput screening approach. <b><i>Methods:</i></b> A lentiviral pool of 63 miRNA inhibition constructs was used to identify miRNAs essential to cell growth in three cHL cell lines in duplicate. As a negative control we also infected cHL cell lines with a lentiviral barcoded empty vector pool consisting of 222 constructs. The abundance of individual constructs was followed over time by a next generation sequencing approach. The effect on growth was confirmed using individual GFP competition assays and on apoptosis using Annexin-V staining. Our previously published Argonaute 2 (Ago2) immunoprecipitation (IP) data were used to identify target genes relevant for cell growth / apoptosis. Luciferase assays and western blotting were performed to confirm targeting by miRNAs. <b><i>Results:</i></b> Four miRNA inhibition constructs, i.e. miR-449a-5p, miR-625-5p, let-7f-2-3p and miR-21-5p, showed a significant decrease in abundance in at least 4 of 6 infections. In contrast, none of the empty vector constructs showed a significant decrease in abundance in 3 or more of the 6 infections. The most abundantly expressed miRNA, i.e. miR-21-5p, showed significantly higher expression levels in cHL compared to GC-B cells. GFP competition assays confirmed the negative effect of miR-21-5p inhibition on HL cell growth. Annexin-V staining of cells infected with miR-21-5p inhibitor indicated a significant increase in apoptosis at day 7 and 9 after viral infection, consistent with the decrease in growth. Four miR-21-5p cell growth- and apoptosis-associated targets were AGO2-IP enriched in cHL cell lines and showed a significant decrease in expression in cHL cell lines in comparison to normal GC-B cells. For the two most abundantly expressed, i.e. BTG2 and PELI1, we confirmed targeting by miR-21-5p using luciferase assays and for PELI1 we also confirmed this at the protein level by western blotting. <b><i>Conclusion:</i></b> Using a miRNA loss-of-function high-throughput screen we identified four miRNAs with oncogenic effects in cHL and validated the results for the in cHL abundantly expressed miR-21-5p. MiR-21-5p is upregulated in cHL compared to GC-B cells and protects cHL cells from apoptosis possibly via targeting BTG2 and PELI1.
DOI: 10.6084/m9.figshare.7047686
title: ONT MinION reads

description: ONT MinION reads after demultiplexing, basecalling (Albacore - version 1.1.0), trimming and filtering out chimeras (Porechop - version 0.2.1).<br>These ONT reads were used to perform hybrid assemblies with Illumina NextSeq/MiSeq data using Unicycler (version 0.4.1).
DOI: 10.6084/m9.figshare.7047686.v1
title: ONT MinION reads

description: ONT MinION reads after demultiplexing, basecalling (Albacore - version 1.1.0), trimming and filtering out chimeras (Porechop - version 0.2.1).<br>These ONT reads were used to perform hybrid assemblies with Illumina NextSeq/MiSeq data using Unicycler (version 0.4.1).
DOI: 10.6084/m9.figshare.7047677
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v1
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v4
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v5
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v6
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v7
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v8
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v9
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v10
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v11
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v12
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v13
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v15
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047677.v14
title: Supplementary Material for: Challenges and Opportunities during the Complementary Feeding Period

description: No abstract
DOI: 10.6084/m9.figshare.7047566
title: Additional file 5: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on genes present in genomic islands in all the strains. (XLSX 137Â kb)
DOI: 10.6084/m9.figshare.7047566.v1
title: Additional file 5: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on genes present in genomic islands in all the strains. (XLSX 137Â kb)
DOI: 10.6084/m9.figshare.7047560
title: Additional file 3: of Predicting participation of people with impaired vision in epidemiological studies

description: Data used and analysed in this study. (XLSX 101 kb)
DOI: 10.6084/m9.figshare.7047560.v1
title: Additional file 3: of Predicting participation of people with impaired vision in epidemiological studies

description: Data used and analysed in this study. (XLSX 101 kb)
DOI: 10.6084/m9.figshare.7047548
title: Additional file 4: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on the unique genes present in the strains under study. (XLSX 29Â kb)
DOI: 10.6084/m9.figshare.7047548.v1
title: Additional file 4: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on the unique genes present in the strains under study. (XLSX 29Â kb)
DOI: 10.6084/m9.figshare.7047530
title: Additional file 3: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on the accessory genes present in the strains under study. (XLSX 115Â kb)
DOI: 10.6084/m9.figshare.7047530.v1
title: Additional file 3: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on the accessory genes present in the strains under study. (XLSX 115Â kb)
DOI: 10.6084/m9.figshare.7047512
title: Additional file 2: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on the core genes present in the genomes under study (XLSX 57Â kb)
DOI: 10.6084/m9.figshare.7047512.v1
title: Additional file 2: of Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

description: Detailed information on the core genes present in the genomes under study (XLSX 57Â kb)
DOI: 10.6084/m9.figshare.7047509
title: MOESM2 of Measuring DNA content in live cells by fluorescence microscopy

description: Additional file 2. ProcessDNA MATLAB file.
DOI: 10.6084/m9.figshare.7047509.v1
title: MOESM2 of Measuring DNA content in live cells by fluorescence microscopy

description: Additional file 2. ProcessDNA MATLAB file.
DOI: 10.6084/m9.figshare.7047485
title: Additional file 2: of Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

description: Raw data. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.7047485.v1
title: Additional file 2: of Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

description: Raw data. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.7047476
title: Additional file 1: of Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

description: Raw data. (XLSX 91Â kb)
DOI: 10.6084/m9.figshare.7047476.v1
title: Additional file 1: of Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

description: Raw data. (XLSX 91Â kb)
DOI: 10.6084/m9.figshare.7047440
title: Additional file 5: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S4. Differentially regulated pathways in MM134 and SUM44 long-term estrogen deprivation (LTED) cells. (XLSX 135 kb)
DOI: 10.6084/m9.figshare.7047440.v1
title: Additional file 5: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S4. Differentially regulated pathways in MM134 and SUM44 long-term estrogen deprivation (LTED) cells. (XLSX 135 kb)
DOI: 10.6084/m9.figshare.7047428
title: Additional file 4: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S3. Differentially expressed genes in MM134 and SUM44 long-term estrogen deprivation (LTED) cells and SUM44 tamoxifen-resistant cell (SUM44 TamR) cells. (XLSX 3466 kb)
DOI: 10.6084/m9.figshare.7047428.v1
title: Additional file 4: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S3. Differentially expressed genes in MM134 and SUM44 long-term estrogen deprivation (LTED) cells and SUM44 tamoxifen-resistant cell (SUM44 TamR) cells. (XLSX 3466 kb)
DOI: 10.6084/m9.figshare.7047416
title: Additional file 3: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S2. Mapping rate of Salmon. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.7047416.v1
title: Additional file 3: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S2. Mapping rate of Salmon. (XLSX 9 kb)
DOI: 10.6084/m9.figshare.7047404
title: Additional file 2: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S1. Sequences of primers and small interfering RNAs (siRNAs). (XLSX 9 kb)
DOI: 10.6084/m9.figshare.7047404.v1
title: Additional file 2: of Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

description: Table S1. Sequences of primers and small interfering RNAs (siRNAs). (XLSX 9 kb)
DOI: 10.6084/m9.figshare.7047308
title: MOESM1 of miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/Î˛-catenin signaling pathway

description: Additional file 1. The original data of western blot in this study.
DOI: 10.6084/m9.figshare.7047308.v1
title: MOESM1 of miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/Î˛-catenin signaling pathway

description: Additional file 1. The original data of western blot in this study.
DOI: 10.6084/m9.figshare.7047302
title: Additional file 9: of Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

description: Table S5. and lists human retinal disease genes, from RetNet [30]. (XLS 45 kb)
DOI: 10.6084/m9.figshare.7047302.v1
title: Additional file 9: of Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

description: Table S5. and lists human retinal disease genes, from RetNet [30]. (XLS 45 kb)
DOI: 10.6084/m9.figshare.7047293
title: MOESM2 of A systems approach to assess climate change mitigation options in landscapes of the United States forest sector

description: Additional file 2. Appendix S2: CBMF-HWP site-level modeling parameters.
DOI: 10.6084/m9.figshare.7047293.v1
title: MOESM2 of A systems approach to assess climate change mitigation options in landscapes of the United States forest sector

description: Additional file 2. Appendix S2: CBMF-HWP site-level modeling parameters.
DOI: 10.6084/m9.figshare.7047287
title: Additional file 1: of Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes

description: Table S1. Dataset list of studied species. Dataset list of studied species, with relative coding based on their color pattern [52], color pattern ontogenesis [64–72], and number of host sea anemones [33] and with quantifications of dorsal fin shape and body elongation. Photographs of specimens for quantifications of dorsal fin shape and body elongation were obtained from online databases (FishBase and “J. E. Randall’s Fish Photos” http://pbs.bishopmuseum.org/images/JER/ ), or nicely provided by J. Williams. Others were studied in the marine vertebrate collections of S. Planes (CRIOBE) and the Museum of Natural National History (MNHN). Excel document 19 ko. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.7047290
title: Additional file 8: of Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

description: Table S4. and lists candidates for exclusion - genes with predicted pathogenic variants in many exome projects or across multiple families exhibiting a variety of phenotypes. This list consists of the genes in Supplementary Tables S1 and S2 from [29]. (XLS 46 kb)
DOI: 10.6084/m9.figshare.7047287.v1
title: Additional file 1: of Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes

description: Table S1. Dataset list of studied species. Dataset list of studied species, with relative coding based on their color pattern [52], color pattern ontogenesis [64–72], and number of host sea anemones [33] and with quantifications of dorsal fin shape and body elongation. Photographs of specimens for quantifications of dorsal fin shape and body elongation were obtained from online databases (FishBase and “J. E. Randall’s Fish Photos” http://pbs.bishopmuseum.org/images/JER/ ), or nicely provided by J. Williams. Others were studied in the marine vertebrate collections of S. Planes (CRIOBE) and the Museum of Natural National History (MNHN). Excel document 19 ko. (XLSX 18 kb)
DOI: 10.6084/m9.figshare.7047290.v1
title: Additional file 8: of Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

description: Table S4. and lists candidates for exclusion - genes with predicted pathogenic variants in many exome projects or across multiple families exhibiting a variety of phenotypes. This list consists of the genes in Supplementary Tables S1 and S2 from [29]. (XLS 46 kb)
DOI: 10.6084/m9.figshare.7047275
title: Additional file 7: of Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

description: Table S3. listing genes reported to underlie deafness in humans and/or mice. (XLS 45 kb)