DOI: 10.7270/q24q7wt8
title: BindingDB Entry 50046897: Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).

description: Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, ALK tyrosine kinase receptor, AXL receptor tyrosine kinase, Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase, Activin receptor-like kinase 3 (ALK-3), Aurora kinase B/Inner centromere protein, BR serine/threonine-protein kinase 1, BR serine/threonine-protein kinase 2, Beta-adrenergic receptor kinase 2, Bone morphogenetic protein receptor type-2, C-RAF, CAMK2A, CAMK2B, CDC2-like kinase 3 (CLK3), CDK2/Cyclin A1, CDK3/E, CDK6/G1/S-specific cyclin D3, CaM kinase I alpha, CaM kinase I delta, CaM kinase I gamma, CaM kinase II, CaM kinase IV, CaM-kinase kinase alpha, CaM-kinase kinase beta, Calcium/calmodulin-dependent protein kinase type 1B, Casein Kinase II, Casein kinase I, Casein kinase I delta/epsilon, Casein kinase I isoform delta, Casein kinase I isoform gamma-3, Casein kinase I/MDM2, Casein kinase II, Cyclin-Dependent Kinase 1 (CDK1), Cyclin-Dependent Kinase 2 (CDK2), Cyclin-Dependent Kinase 4 (CDK4), Cyclin-Dependent Kinase 5 (CDK5), Cyclin-Dependent Kinase 7 (CDK7), Cyclin-K, Cyclin-dependent kinase 6/G1/S-specific cyclin D1, Death-associated protein kinase 1, Death-associated protein kinase 2, Death-associated protein kinase 3, Discoidin domain-containing receptor 2, Dual serine/threonine and tyrosine protein kinase, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity protein kinase CLK2, Dual specificity protein kinase CLK4, Dual specificity testis-specific protein kinase 1, Dual specificity tyrosine-phosphorylation-regulated kinase 4, Dual specificty protein kinase CLK1, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Dual-specificity tyrosine-phosphorylation regulated kinase 2, Dual-specificity tyrosine-phosphorylation regulated kinase 3, Dual-specificity tyrosine-regulated kinases 1B, EPHB1, Ephrin receptor, Ephrin type-A receptor 1 (EPHA1), Ephrin type-A receptor 3 (EPHA3), Ephrin type-A receptor 7, Ephrin type-B receptor 3 (EPHB3), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Epithelial discoidin domain-containing receptor 1, Extracellular signal-regulated kinase 5 (ERK5), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, G protein-coupled receptor kinase 4, G protein-coupled receptor kinase 5, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase 7, G-protein coupled receptor kinase 2, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Homeodomain-interacting protein kinase 1, Homeodomain-interacting protein kinase 2 (HIPK2), Homeodomain-interacting protein kinase 3, Homeodomain-interacting protein kinase 4, IKK epsilon/TBK1, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin receptor-related protein, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, JAK2/TYK2, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, LIM domain kinase 1, LIM domain kinase 2, Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), Leukocyte tyrosine kinase receptor, MAP kinase ERK2, MAP kinase p38, MAP kinase signal-integrating kinase 2, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 3, MAP kinase-activated protein kinase 5, MAP kinase-interacting serine/threonine-protein kinase MNK1, MAP/microtubule affinity-regulating kinase 2, MAP/microtubule affinity-regulating kinase 4, MER intracellular domain/EGFR extracellular domain chimera, Macrophage colony stimulating factor receptor, Macrophage-stimulating protein receptor, Maternal embryonic leucine zipper kinase, Misshapen-like kinase 1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 13 (MAPK13), Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 15, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase 10, Mitogen-activated protein kinase kinase kinase 11, Mitogen-activated protein kinase kinase kinase 12, Mitogen-activated protein kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase 5, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase 9, Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Mixed lineage kinase 7, Muscle, skeletal receptor tyrosine protein kinase, Myosin light chain kinase, Myosin-IIIB, Myotonin-protein kinase, NT-3 growth factor receptor, NUAK family SNF1-like kinase 1, NUAK family SNF1-like kinase 2, Neurotrophic tyrosine kinase receptor, Neurotrophic tyrosine kinase receptor type 2, Non-receptor tyrosine-protein kinase TNK1, PAK1, PAS domain-containing serine/threonine-protein kinase, PDZ-binding kinase, PKC alpha and beta-2, PTK2B protein tyrosine kinase 2 beta (PTK2B), Phosphorylase kinase, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Protein kinase C (PKC), Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C eta type, Protein kinase C iota (PKCι), Protein kinase C theta type, Protein kinase C, epsilon, Protein kinase C, gamma, Protein kinase C-binding protein 1, Protein kinase N1, Protein kinase N2, Proto-oncogene tyrosine-protein kinase ROS, RAF serine/threonine protein kinase, Receptor tyrosine-protein kinase erbB-4 (HER4), Receptor-interacting serine/threonine-protein kinase 3, Rho-associated protein kinase, Rhodopsin kinase, Ribosomal protein S6 kinase (P70S6K), Ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha 2, Ribosomal protein S6 kinase alpha 3, Ribosomal protein S6 kinase alpha 4, Ribosomal protein S6 kinase alpha 5, Ribosomal protein S6 kinase alpha 6, SM myosin light chain kinase (smMLCK), SRC, STE20/SPS1-related proline-alanine-rich protein kinase, Serine/threonine protein kinase NLK, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 11, Serine/threonine-protein kinase 16, Serine/threonine-protein kinase 17A, Serine/threonine-protein kinase 2, Serine/threonine-protein kinase 24, Serine/threonine-protein kinase 25, Serine/threonine-protein kinase 32B, Serine/threonine-protein kinase 32C, Serine/threonine-protein kinase 33, Serine/threonine-protein kinase 38, Serine/threonine-protein kinase 38-like, Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Aurora-C, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2, Serine/threonine-protein kinase D3, Serine/threonine-protein kinase DCLK1, Serine/threonine-protein kinase DCLK2, Serine/threonine-protein kinase ICK, Serine/threonine-protein kinase LATS1, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MRCK beta, Serine/threonine-protein kinase MRCK gamma, Serine/threonine-protein kinase MRCK-A, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase N3, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase NEK7, Serine/threonine-protein kinase NEK9, Serine/threonine-protein kinase Nek1, Serine/threonine-protein kinase Nek11, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase Nek3, Serine/threonine-protein kinase Nek4, Serine/threonine-protein kinase Nek5, Serine/threonine-protein kinase OSR1, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK6, Serine/threonine-protein kinase PAK7, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase PLK2, Serine/threonine-protein kinase PLK3, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase PRKX, Serine/threonine-protein kinase RIPK2, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase SRPK1, Serine/threonine-protein kinase SRPK2, Serine/threonine-protein kinase SRPK3, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase Sgk2, Serine/threonine-protein kinase Sgk3, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase TAO3, Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase ULK2, Serine/threonine-protein kinase ULK3, Serine/threonine-protein kinase VRK1, Serine/threonine-protein kinase VRK2, Serine/threonine-protein kinase WEE1, Serine/threonine-protein kinase WNK1, Serine/threonine-protein kinase WNK2, Serine/threonine-protein kinase WNK3, Serine/threonine-protein kinase c-TAK1, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase receptor R3, Serine/threonine-protein kinase tousled-like 1, Serine/threonine-protein kinase tousled-like 2, TAK1/TAB1, TGF-beta receptor type I, TGF-beta receptor type II, TRAF2 and NCK-interacting protein kinase (TNIK), Tau-tubulin kinase 1, Tau-tubulin kinase 2, Testis-specific serine/threonine-protein kinase 1, Testis-specific serine/threonine-protein kinase 2, Testis-specific serine/threonine-protein kinase 3, Testis-specific serine/threonine-protein kinase 6, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BRK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase CTK, Tyrosine-protein kinase FER, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase TEC, Tyrosine-protein kinase TXK (TXK), Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor TYRO3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), c-Jun N-terminal kinase, JNK, cAMP-dependent protein kinase (PKA), cAMP-dependent protein kinase catalytic subunit gamma, cGMP-dependent protein kinase, myosin light chain kinase 2, p21-Activated kinase 2 (PAK2), p21-Activated kinase 3 (PAK3), and p38 delta/gamma, Uniprot A0A024RDK3, L7RSL3, O00141, O00311, O00444, O00506, O14757, O14920, O14965, O15075, O15111, O15146, O15264, O15530, O43293, O43318, O43353, O43781, O60285, O60674, O75116, O75385, O75582, O75676, O75716, O75909, O75914, O94804, O94806, O95747, O95819, O95835, O96013, O96017, P00519, P00533, P04049, P04626, P04629, P05129, P05771, P06213, P06239, P06241, P06493, P07332, P07333, P07947, P07948, P07949, P08069, P08581, P08631, P08922, P09619, P09769, P10398, P10721, P11309, P11362, P11802, P12931, P14616, P14635, P15056, P15735, P16234, P16591, P17252, P17948, P19784, P20248, P21709, P21802, P22455, P22607, P22612, P22694, P23443, P23458, P24385, P24723, P24864, P24941, P25098, P27361, P27448, P28482, P29317, P29320, P29322, P29323, P29376, P29597, P30281, P30291, P30530, P31749, P31751, P32298, P34947, P35626, P35916, P35968, P36507, P36888, P36894, P36897, P37023, P37173, P41240, P41279, P41743, P42679, P42680, P42681, P42684, P42685, P43250, P43403, P43405, P45983, P45984, P45985, P46734, P48729, P48730, P49137, P49674, P49759, P49760, P49761, P49840, P50613, P51451, P51617, P51812, P51813, P51817, P51946, P51955, P51956, P51957, P52333, P52564, P53350, P53355, P53667, P53671, P53778, P53779, P54753, P54756, P54760, P54762, P54764, P57059, P68400, P78362, P78368, P78396, P80192, Q00526, Q00534, Q00535, Q02156, Q02750, Q02763, Q02779, Q04759, Q04912, Q05397, Q05513, Q05655, Q06187, Q06418, Q07912, Q08345, Q08881, Q09013, Q12851, Q12852, Q12866, Q13043, Q13153, Q13164, Q13177, Q13188, Q13233, Q13464, Q13470, Q13554, Q13555, Q13557, Q13627, Q13873, Q13882, Q13976, Q14012, Q14164, Q14289, Q14680, Q15078, Q15139, Q15208, Q15303, Q15349, Q15375, Q15418, Q15569, Q15746, Q15759, Q15831, Q15835, Q16288, Q16512, Q16513, Q16539, Q16566, Q16584, Q16620, Q16644, Q16816, Q16832, Q32MK0, Q541P7, Q5S007, Q5TCY1, Q5VT25, Q6DT37, Q6FI23, Q6IQ55, Q6P2M8, Q6P3R8, Q6P5Z2, Q6PHR2, Q6XUX3, Q7KZI7, Q7L7X3, Q86UE8, Q86UX6, Q86V86, Q86Y07, Q86Z02, Q8IU85, Q8IVH8, Q8IW41, Q8IWQ3, Q8IYT8, Q8N4C8, Q8N568, Q8N5S9, Q8NE63, Q8NG66, Q8TD08, Q8TD19, Q8TDC3, Q8TDX7, Q8TF76, Q8WTQ7, Q8WXR4, Q92630, Q92918, Q96BR1, Q96GD4, Q96KB5, Q96L34, Q96NX5, Q96PF2, Q96PN8, Q96PY6, Q96RG2, Q96RR4, Q96SB4, Q99683, Q99759, Q99986, Q9BUB5, Q9BXA6, Q9BXA7, Q9BYP7, Q9BYT3, Q9BZL6, Q9H093, Q9H0K1, Q9H1R3, Q9H2G2, Q9H2K8, Q9H2X6, Q9H3Y6, Q9H422, Q9H4A3, Q9H4B4, Q9HAZ1, Q9HBH9, Q9HBY8, Q9HC98, Q9HCP0, Q9NQU5, Q9NR20, Q9NRM7, Q9NWZ3, Q9NY57, Q9NYL2, Q9NYY3, Q9P0L2, Q9P1W9, Q9P286, Q9P289, Q9UBE8, Q9UBS0, Q9UBU7, Q9UEE5, Q9UEW8, Q9UF33, Q9UHD2, Q9UIK4, Q9UK32, Q9UKE5, Q9UKI8, Q9UL54, Q9ULU4, Q9UM73, Q9UPE1, Q9UPZ9, Q9UQB9, Q9UQM7, Q9Y243, Q9Y2H1, Q9Y2U5, Q9Y3S1, Q9Y463, Q9Y572, Q9Y5S2, Q9Y6E0, and Q9Y6M4