cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5799123.v1
title: Effects of Telestroke on Thrombolysis Times and Outcomes: A Meta-analysis

description: <b>Objective</b>: Telestroke systems are tools, used to provide an advanced stroke care in regions without sufficient neurologic services. We performed this meta-analysis to assess the effects of telemedicine on treatment times and clinical outcomes of acute stroke care. <b>Methods:</b> A literature search of PubMed, SCOPUS, and Cochrane CENTRAL was conducted for original studies investigating telemedicine applications in acute stroke care. Dichotomous data on treatment outcomes were pooled as odds ratios (ORs), while continuous data on thrombolysis times were pooled as mean differences (MDs) with 95% confidence interval (CI), using RevMan software (version 5.3). <b>Results</b>: Pooling data from 26 studies (6605 thrombolysed patients) showed no significant differences between the telestroke and control groups in terms of in-hospital mortality (OR = 1.21, 95% CI [0.98, 1.49]), 90-day mortality (OR = 1.08, 95% CI [0.85, 1.37]), symptomatic intracranial hemorrhage (sICH) (OR = 1.10, 95% CI [0.79, 1.53]), and favorable clinical outcome at discharge (OR = 1.03, 95% CI [0.69, 1.53]) and 90 days later (OR = 0.99, 95% CI [0.82, 1.18]). The onset-to-door (OTD) duration (MD = −10.4 minutes, 95% CI [−14.79, −.01]) and length of hospital stay (MD = −0.55 days, 95% CI [−1.02, −0.07]) were significantly shorter in the telestroke group, compared to the control group. Although the overall effect estimate (under the fixed-effect model) showed a significant decrease in the onset-to-treatment (OTT) duration in the telestroke group (MD = −5.83 minutes, 95% CI [−8.57, −3.09]), employing the random-effects model for between-study heterogeneity abolished this significance (MD = −5.90 minutes, 95% CI [−13.23, 1.42]). <b>Conclusion</b>: Telestroke significantly reduced OTD and hospital stay durations in stroke patients without increasing the risk of mortality or sICH. Therefore, telemedicine can improve stroke care in regional areas with minor experience in thrombolysis. Further randomized controlled trials are needed to assess the benefits of telestroke systems, especially in terms of cost-effectiveness and quality of life outcomes.
DOI: 10.6084/m9.figshare.5799120
title: Association between Weather-Related Factors and Cardiac Arrest of Presumed Cardiac Etiology: A Prospective Observational Study Based on Out-of-Hospital Care Data

description: <b>Objective</b>: The objective of this study was to determine the association between weather-related factors and out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology. <b>Methods</b>: This was a prospective observational study performed in a prehospital setting. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Weather data (temperature, humidity, air pressure, wind speed) were obtained every minute and matched with the associated rescue mission data. Lowess-Regression analysis was performed to assess the relationship between the above-mentioned weather-related factors and OHCA of presumed cardiac etiology. Additionally, varying measuring-ranges were defined for each weather-related factor in order to compare them with each other with regard to the probability of occurrence of OHCA. <b>Results</b>: During the observation period 1,558 OHCA with presumed cardiac etiology were registered (age: 67 ± 19 yrs; 62% male; hospital admission: 37%; survival to hospital discharge: 6.7%). Compared to moderate temperatures (5 – 25°C), probability of OHCA-occurrence increased significantly at temperatures above 25°C (p = 0.028) and below 5°C p = 0.011). Regarding air humidity, probability of OHCA-occurrence increased below a threshold-value of 75% compared to values above this cut-off (p = 0.006). Decreased probability was seen at moderate atmospheric pressure (1000 hPa – 1020 hPa), whereas increased probability was seen above 1020 hPa (p = 0.023) and below 1000 hPa (p = 0.035). Probability of OHCA-occurrence increased continuously with increasing wind speed (p &lt; 0.001). <b>Conclusions</b>: There are associations between several weather-related factors such as temperature, humidity, air pressure, and wind speed, and occurrence of OHCA of presumed cardiac etiology. Particularly dangerous seem to be cold weather, dry air and strong wind.
DOI: 10.6084/m9.figshare.5799120.v1
title: Association between Weather-Related Factors and Cardiac Arrest of Presumed Cardiac Etiology: A Prospective Observational Study Based on Out-of-Hospital Care Data

description: <b>Objective</b>: The objective of this study was to determine the association between weather-related factors and out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology. <b>Methods</b>: This was a prospective observational study performed in a prehospital setting. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Weather data (temperature, humidity, air pressure, wind speed) were obtained every minute and matched with the associated rescue mission data. Lowess-Regression analysis was performed to assess the relationship between the above-mentioned weather-related factors and OHCA of presumed cardiac etiology. Additionally, varying measuring-ranges were defined for each weather-related factor in order to compare them with each other with regard to the probability of occurrence of OHCA. <b>Results</b>: During the observation period 1,558 OHCA with presumed cardiac etiology were registered (age: 67 ± 19 yrs; 62% male; hospital admission: 37%; survival to hospital discharge: 6.7%). Compared to moderate temperatures (5 – 25°C), probability of OHCA-occurrence increased significantly at temperatures above 25°C (p = 0.028) and below 5°C p = 0.011). Regarding air humidity, probability of OHCA-occurrence increased below a threshold-value of 75% compared to values above this cut-off (p = 0.006). Decreased probability was seen at moderate atmospheric pressure (1000 hPa – 1020 hPa), whereas increased probability was seen above 1020 hPa (p = 0.023) and below 1000 hPa (p = 0.035). Probability of OHCA-occurrence increased continuously with increasing wind speed (p &lt; 0.001). <b>Conclusions</b>: There are associations between several weather-related factors such as temperature, humidity, air pressure, and wind speed, and occurrence of OHCA of presumed cardiac etiology. Particularly dangerous seem to be cold weather, dry air and strong wind.
DOI: 10.6084/m9.figshare.5799111
title: Developing standards for an integrated approach to workplace facilitation for interprofessional teams in health and social care contexts: a Delphi study

description: Integration of health and social care forms part of health and social care policy in many countries worldwide in response to changing health and social care needs. The World Health Organization’s appeal for systems to manage the global epidemiologic transition advocates for provision of care that crosses boundaries between primary, community, hospital, and social care. However, the focus on structural and process changes has not yielded the full benefit of expected advances in care delivery. Facilitating practice in the workplace is a widely recognised cornerstone for developments in the delivery of health and social care as collaborative and inclusive relationships enable frontline staff to develop effective workplace cultures that influence whether transformational change is achieved and maintained. Workplace facilitation embraces a number of different purposes which may not independently lead to better quality of care or improved patient outcomes. Holistic workplace facilitation of learning, development, and improvement supports the integration remit across health and social care systems and avoids duplication of effort and waste of valuable resources. To date, no standards to guide the quality and effectiveness of integrated facilitation have been published. This study aimed to identify key elements constitute standards for an integrated approach to facilitating work-based learning, development, improvement, inquiry, knowledge translation, and innovation in health and social care contexts using a three rounds Delphi survey of facilitation experts from 10 countries. Consensus about priority elements was determined in the final round, following an iteration process that involved modifications to validate content. The findings helped to identify key qualities and skills facilitators need to support interprofessional teams to flourish and optimise performance. Further research could evaluate the impact of skilled integrated facilitation on health and social care outcomes and the well-being of frontline interprofessional teams.
DOI: 10.6084/m9.figshare.5799111.v1
title: Developing standards for an integrated approach to workplace facilitation for interprofessional teams in health and social care contexts: a Delphi study

description: Integration of health and social care forms part of health and social care policy in many countries worldwide in response to changing health and social care needs. The World Health Organization’s appeal for systems to manage the global epidemiologic transition advocates for provision of care that crosses boundaries between primary, community, hospital, and social care. However, the focus on structural and process changes has not yielded the full benefit of expected advances in care delivery. Facilitating practice in the workplace is a widely recognised cornerstone for developments in the delivery of health and social care as collaborative and inclusive relationships enable frontline staff to develop effective workplace cultures that influence whether transformational change is achieved and maintained. Workplace facilitation embraces a number of different purposes which may not independently lead to better quality of care or improved patient outcomes. Holistic workplace facilitation of learning, development, and improvement supports the integration remit across health and social care systems and avoids duplication of effort and waste of valuable resources. To date, no standards to guide the quality and effectiveness of integrated facilitation have been published. This study aimed to identify key elements constitute standards for an integrated approach to facilitating work-based learning, development, improvement, inquiry, knowledge translation, and innovation in health and social care contexts using a three rounds Delphi survey of facilitation experts from 10 countries. Consensus about priority elements was determined in the final round, following an iteration process that involved modifications to validate content. The findings helped to identify key qualities and skills facilitators need to support interprofessional teams to flourish and optimise performance. Further research could evaluate the impact of skilled integrated facilitation on health and social care outcomes and the well-being of frontline interprofessional teams.
DOI: 10.6084/m9.figshare.5799093
title: Supplementary Material for: Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices

description: <b><i>Background:</i></b> Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow. <b><i>Methods:</i></b> The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of dietary potassium and sodium:potassium intake with cognitive decline, and associations of these nutrients with micro- and macro-structural brain magnetic resonance imaging (MRI) indices. In all, 1,194 participants in the Health Aging and Body Composition study with measurements of dietary sodium intake (food frequency questionnaire [FFQ]) and change in the modified Mini Mental State Exam (3MS) were included. <b><i>Results:</i></b> The age of participants was 74 ± 3 years with a mean dietary sodium intake of 2,677 ± 1,060 mg/day. During follow-up (6.9 ± 0.1 years), 340 (28%) had a clinically significant decline in 3MS score (≥1.5 SD of mean decline). After adjustment, dietary sodium intake was not associated with odds of cognitive decline (OR 0.96, 95% CI 0.50–1.84 per doubling of sodium). Similarly, potassium was not associated with cognitive decline; however, higher sodium:potassium intake was associated with increased odds of cognitive decline (OR 2.02 [95% CI 1.01–4.03] per unit increase). Neither sodium or potassium alone nor sodium:potassium were associated with micro- or macro-structural brain MRI indices. These results are limited by the use of FFQ. <b><i>Conclusions:</i></b> In community-dwelling older adults, higher sodium:potassium, but not sodium or potassium intake alone, was associated with decline in cognitive function, with no associations observed with micro- and macro-structural brain MRI indices. These findings do not support reduction dietary sodium/increased potassium intake to prevent cognitive decline with aging.
DOI: 10.6084/m9.figshare.5799093.v1
title: Supplementary Material for: Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices

description: <b><i>Background:</i></b> Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow. <b><i>Methods:</i></b> The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of dietary potassium and sodium:potassium intake with cognitive decline, and associations of these nutrients with micro- and macro-structural brain magnetic resonance imaging (MRI) indices. In all, 1,194 participants in the Health Aging and Body Composition study with measurements of dietary sodium intake (food frequency questionnaire [FFQ]) and change in the modified Mini Mental State Exam (3MS) were included. <b><i>Results:</i></b> The age of participants was 74 ± 3 years with a mean dietary sodium intake of 2,677 ± 1,060 mg/day. During follow-up (6.9 ± 0.1 years), 340 (28%) had a clinically significant decline in 3MS score (≥1.5 SD of mean decline). After adjustment, dietary sodium intake was not associated with odds of cognitive decline (OR 0.96, 95% CI 0.50–1.84 per doubling of sodium). Similarly, potassium was not associated with cognitive decline; however, higher sodium:potassium intake was associated with increased odds of cognitive decline (OR 2.02 [95% CI 1.01–4.03] per unit increase). Neither sodium or potassium alone nor sodium:potassium were associated with micro- or macro-structural brain MRI indices. These results are limited by the use of FFQ. <b><i>Conclusions:</i></b> In community-dwelling older adults, higher sodium:potassium, but not sodium or potassium intake alone, was associated with decline in cognitive function, with no associations observed with micro- and macro-structural brain MRI indices. These findings do not support reduction dietary sodium/increased potassium intake to prevent cognitive decline with aging.
DOI: 10.6084/m9.figshare.5799015.v1
title: Schematic illustration of lattice transitions in Grain Hill model

description: Example of a four-by-four lattice, illustrating the first nine states in the Grain Hill model and including an example transition in which a falling grain trades places with the fluid cell below it.
DOI: 10.6084/m9.figshare.5799003
title: ADVANCED DESIGN SOLUTIONS FOR HIGH-PRECISION WOODWORKING MACHINES

description: With the aim at performing the highest precision during woodworking, a mix of alternative approaches, fruitfully integrated in a common design strategy, is essential. This paper represents an overview of technical solutions, recently developed by authors, in design of machine tools and their final effects on manufacturing. The most advanced solutions in machine design are reported side by side with common practices or little everyday expedients. These design actions are directly or indirectly related to the rational use of materials, sometimes very uncommon, as in the case of magnetorheological fluids chosen to implement an active control in speed and force on the electro-spindle, and permitting to improve the quality of wood machining. Other actions are less unusual, as in the case of the adoption of innovative anti-vibration supports for basement. Tradition or innovation, all these technical solutions contribute to the final result: the highest precision in wood machining.
DOI: 10.6084/m9.figshare.5799000
title: Wright-Fisher Simulation Model

description: C# Code that was used to implement Wright-Fisher simulation model for publication "Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium"<br>
DOI: 10.6084/m9.figshare.5798991
title: MERGING TECHNICAL COMPETENCES AND HUMAN RESOURCES WITH THE AIM AT CONTRIBUTING TO TRANSFORM THE ADRIATIC AREA IN A STABLE HUB FOR A SUSTAINABLE TECHNOLOGICAL DEVELOPMENT

description: The Vision of Europe as knowledge-based society is<br>funded on availability and application of knowledge in all<br>segments of European life. Universities, as key provider of<br>knowledge, and industry, as its largest consumer, are two<br>pillows of this vision. Academic Institutions has a double role<br>in provisioning of knowledge: "research" for creation of new<br>knowledge and "education" as dissemination of current<br>knowledge. In this investigation, a four-year cross-border<br>collaboration is described, including strategy, mechanisms<br>and tools adopted for supporting a wider cooperation between<br>universities and industry. Background, challenges and<br>concepts of long-term sustainability are also presented.<br>Furthermore, a general overview of technical outcomes and<br>advances, provided by a research and development joint<br>action, thanks to this international cooperation, is illustrated.<br>A deeper description regarding these technical investigations<br>is proposed in the following articles of this Special Issue on<br>"Wood: an Ancient Material for a Modern Quality".
DOI: 10.6084/m9.figshare.5798991.v1
title: MERGING TECHNICAL COMPETENCES AND HUMAN RESOURCES WITH THE AIM AT CONTRIBUTING TO TRANSFORM THE ADRIATIC AREA IN A STABLE HUB FOR A SUSTAINABLE TECHNOLOGICAL DEVELOPMENT

description: The Vision of Europe as knowledge-based society is<br>funded on availability and application of knowledge in all<br>segments of European life. Universities, as key provider of<br>knowledge, and industry, as its largest consumer, are two<br>pillows of this vision. Academic Institutions has a double role<br>in provisioning of knowledge: "research" for creation of new<br>knowledge and "education" as dissemination of current<br>knowledge. In this investigation, a four-year cross-border<br>collaboration is described, including strategy, mechanisms<br>and tools adopted for supporting a wider cooperation between<br>universities and industry. Background, challenges and<br>concepts of long-term sustainability are also presented.<br>Furthermore, a general overview of technical outcomes and<br>advances, provided by a research and development joint<br>action, thanks to this international cooperation, is illustrated.<br>A deeper description regarding these technical investigations<br>is proposed in the following articles of this Special Issue on<br>"Wood: an Ancient Material for a Modern Quality".
DOI: 10.6084/m9.figshare.5798988
title: Supplementary Material for: Social and Behavioural Determinants of the Difference in Survival among Older Adults in Japan and England

description: <b><i>Background:</i></b> A rapidly ageing population presents major challenges to health and social care services. Cross-country comparative studies on survival among older adults are limited. In addition, Japan, the country with the longest life expectancy, is rarely included in these cross-country comparisons. <b><i>Objective:</i></b> We examined the relative contributions of social and behavioural factors on the differences in survival among older people in Japan and England. <b><i>Methods:</i></b> We used data from the Japan Gerontological Evaluation Study (JAGES; <i>n</i> = 13,176) and the English Longitudinal Study of Ageing (ELSA; <i>n</i> = 5,551) to analyse all-cause mortality up to 9.4 years from the baseline. Applying Laplace regression models, the 15th survival percentile difference was estimated. <b><i>Results:</i></b> During the follow-up, 31.3% of women and 38.6% of men in the ELSA died, whereas 19.3% of women and 31.3% of men in the JAGES died. After adjusting for age and baseline health status, JAGES participants had longer survival than ELSA participants by 318.8 days for women and by 131.6 days for men. Family-based social relationships contributed to 105.4 days longer survival in JAGES than ELSA men. Fewer friendship-based social relationships shortened the JAGES men’s survival by 45.4 days compared to ELSA men. Currently not being a smoker contributed to longer survival for JAGES women (197.7 days) and ELSA men (46.6 days), and having lower BMI reduced the survival of JAGES participants by 129.0 days for women and by 212.2 days for men. <b><i>Conclusion:</i></b> Compared to participants in England, Japanese older people lived longer mainly because of non-smoking for women and family-based social relationships for men. In contrast, a lower rate of underweight, men’s better friendship-based social relationships, and a lower smoking rate contributed to survival among participants in England.
DOI: 10.6084/m9.figshare.5798988.v1
title: Supplementary Material for: Social and Behavioural Determinants of the Difference in Survival among Older Adults in Japan and England

description: <b><i>Background:</i></b> A rapidly ageing population presents major challenges to health and social care services. Cross-country comparative studies on survival among older adults are limited. In addition, Japan, the country with the longest life expectancy, is rarely included in these cross-country comparisons. <b><i>Objective:</i></b> We examined the relative contributions of social and behavioural factors on the differences in survival among older people in Japan and England. <b><i>Methods:</i></b> We used data from the Japan Gerontological Evaluation Study (JAGES; <i>n</i> = 13,176) and the English Longitudinal Study of Ageing (ELSA; <i>n</i> = 5,551) to analyse all-cause mortality up to 9.4 years from the baseline. Applying Laplace regression models, the 15th survival percentile difference was estimated. <b><i>Results:</i></b> During the follow-up, 31.3% of women and 38.6% of men in the ELSA died, whereas 19.3% of women and 31.3% of men in the JAGES died. After adjusting for age and baseline health status, JAGES participants had longer survival than ELSA participants by 318.8 days for women and by 131.6 days for men. Family-based social relationships contributed to 105.4 days longer survival in JAGES than ELSA men. Fewer friendship-based social relationships shortened the JAGES men’s survival by 45.4 days compared to ELSA men. Currently not being a smoker contributed to longer survival for JAGES women (197.7 days) and ELSA men (46.6 days), and having lower BMI reduced the survival of JAGES participants by 129.0 days for women and by 212.2 days for men. <b><i>Conclusion:</i></b> Compared to participants in England, Japanese older people lived longer mainly because of non-smoking for women and family-based social relationships for men. In contrast, a lower rate of underweight, men’s better friendship-based social relationships, and a lower smoking rate contributed to survival among participants in England.