cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11460729
title: T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis

description: The aim of the present study was to evaluate the impact of <i>SEMA4A</i> genetic variants on expression of sema4A protein and its relation to autoimmunity development in Systemic Lupus Erythematosus and Rheumatoid Arthritis patients. A total of 541 SLE patients, 390 RA patients and 607 healthy individuals were genotyped. We also assessed <i>SEMA4A</i> mRNA expression from whole blood cells and the in vitro protein production from resting and activated T lymphocytes as well as mature dendritic cells from healthy individuals stratified according to their genotypes for SLE/RA associated <i>SEMA4A</i> variants. Our results showed that T/T genotype for rs3738581 SNP is associated with both RA and SLE development (<i>p</i> = .000053, OR = 2.35; <i>p</i> = .0019, OR = 2.07, respectively; statistical power = 100%) and also to an increased in vitro sema4A production in active T lymphocytes. Our findings are indicative of a T cell-specific upregulation of sema4A in the presence of T/T genotype, being a risk factor for SLE and RA.
DOI: 10.6084/m9.figshare.11460714
title: Choosing task difficulty etc. Matarazzo et al - 2019(1).sav

description: Dataset of the study "Choosing task difficulty: the effects of performance feedback, related emotions and conditional monetary reward".<br>
DOI: 10.6084/m9.figshare.11460729.v1
title: T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis

description: The aim of the present study was to evaluate the impact of <i>SEMA4A</i> genetic variants on expression of sema4A protein and its relation to autoimmunity development in Systemic Lupus Erythematosus and Rheumatoid Arthritis patients. A total of 541 SLE patients, 390 RA patients and 607 healthy individuals were genotyped. We also assessed <i>SEMA4A</i> mRNA expression from whole blood cells and the in vitro protein production from resting and activated T lymphocytes as well as mature dendritic cells from healthy individuals stratified according to their genotypes for SLE/RA associated <i>SEMA4A</i> variants. Our results showed that T/T genotype for rs3738581 SNP is associated with both RA and SLE development (<i>p</i> = .000053, OR = 2.35; <i>p</i> = .0019, OR = 2.07, respectively; statistical power = 100%) and also to an increased in vitro sema4A production in active T lymphocytes. Our findings are indicative of a T cell-specific upregulation of sema4A in the presence of T/T genotype, being a risk factor for SLE and RA.
DOI: 10.6084/m9.figshare.11460714.v1
title: Choosing task difficulty etc. Matarazzo et al - 2019(1).sav

description: Dataset of the study "Choosing task difficulty: the effects of performance feedback, related emotions and conditional monetary reward".<br>
DOI: 10.6084/m9.figshare.11460573
title: Sequence and functional analysis of a TERMINAL FLOWER 1 homolog from <i>Brassica juncea</i>: a putative biotechnological tool for flowering time adjustment

description: Flowering time is an important agricultural trait of the oil crop <i>Brassica juncea</i> (<i>B. juncea</i>), as accelerated flowering enables avoidance of terminal drought leading to increased yields. One gene known to control flowering time is <i>TERMINAL FLOWER 1</i> (<i>TFL1</i>), which belongs to a family of phosphatidylethanolamine binding proteins, which can either repress or promote flowering time. Here, a <i>TFL1</i> homolog, named <i>BjTFL1</i>, has been isolated from <i>B. juncea</i>, which shared 95% amino acid identity with TFL1 from <i>Arabidopsis thaliana</i>. Sequence analysis predicts the BjTFL1 protein contains the ligand-binding site, conserved motifs and other amino acid residues that are critical for TFL1 function. Confirming this as a functional <i>TFL1</i> orthologue, overexpression of <i>BjTFL1</i> under the control of the constitutive 35S promoter in <i>Arabidopsis</i> delayed flowering time. As a proof-of-concept to investigate its utility to shorten flowering time, an RNAi construct containing a partial sequence of <i>BjTFL1</i> was transformed into <i>Arabidopsis</i>. Transcript analysis demonstrated the downregulation of endogenous <i>AtTFL1</i>. Moreover, the RNAi BjTFL1 transgenic lines were early flowering and had fewer rosette and cauline leaves compared to wild-type. Therefore, this <i>BjTFL1</i> RNAi transgene could be used as a biotechnological tool to reduce flowering time in <i>Brassica juncea</i> in a bid to improve agricultural performance.
DOI: 10.6084/m9.figshare.11460573.v1
title: Sequence and functional analysis of a TERMINAL FLOWER 1 homolog from <i>Brassica juncea</i>: a putative biotechnological tool for flowering time adjustment

description: Flowering time is an important agricultural trait of the oil crop <i>Brassica juncea</i> (<i>B. juncea</i>), as accelerated flowering enables avoidance of terminal drought leading to increased yields. One gene known to control flowering time is <i>TERMINAL FLOWER 1</i> (<i>TFL1</i>), which belongs to a family of phosphatidylethanolamine binding proteins, which can either repress or promote flowering time. Here, a <i>TFL1</i> homolog, named <i>BjTFL1</i>, has been isolated from <i>B. juncea</i>, which shared 95% amino acid identity with TFL1 from <i>Arabidopsis thaliana</i>. Sequence analysis predicts the BjTFL1 protein contains the ligand-binding site, conserved motifs and other amino acid residues that are critical for TFL1 function. Confirming this as a functional <i>TFL1</i> orthologue, overexpression of <i>BjTFL1</i> under the control of the constitutive 35S promoter in <i>Arabidopsis</i> delayed flowering time. As a proof-of-concept to investigate its utility to shorten flowering time, an RNAi construct containing a partial sequence of <i>BjTFL1</i> was transformed into <i>Arabidopsis</i>. Transcript analysis demonstrated the downregulation of endogenous <i>AtTFL1</i>. Moreover, the RNAi BjTFL1 transgenic lines were early flowering and had fewer rosette and cauline leaves compared to wild-type. Therefore, this <i>BjTFL1</i> RNAi transgene could be used as a biotechnological tool to reduce flowering time in <i>Brassica juncea</i> in a bid to improve agricultural performance.
DOI: 10.6084/m9.figshare.11460570
title: Effectiveness and safety of Ustekinumab for the treatment of Crohn’s disease in real-life experiences: a meta-analysis of observational studies

description: <b>Background</b>: The aim of this meta-analysis was to estimate the effectiveness and safety of Ustekinumab in Crohn’s disease (CD) reported by observational studies. <b>Research design and methods</b>: PubMed/Medline and Embase were systematically searched through September 2019. Only real-life observational studies were included. <b>Results</b>: Thirteen studies comprising 1450 patients met the inclusion criteria. Ustekinumab was administered subcutaneously at induction among 7 studies, while in 6 studies the intravenous formulation was used. At induction (8–16 weeks), the pooled estimate rates of clinical response and remission were 56% (95% CI: 43-68%; range: 16–94%; I<sup>2</sup> = 94%) and 34% (95% CI: 25–45%; range: 15–58%; I<sup>2</sup> = 90%), respectively. The rate of clinical response was higher among studies which employed the subcutaneous compared with the intravenous induction (68% vs. 38%, p = 0.01). At maintenance, the pooled estimate rates of clinical response, clinical remission, endoscopic response, and endoscopic remission were 62% (95% CI: 50-73%; range: 42–89%; I<sup>2</sup> = 89%), 40% (95% CI: 28–54%; range: 26–73%; I<sup>2</sup> = 90%), 56% (95% CI: 37-73%; range: 20–77%; I<sup>2</sup> = 87%), and 19% (95% CI: 11-30%; range: 7–31%; I<sup>2</sup> = 67%), respectively. <b>Conclusions</b>: Ustekinumab is an effective treatment in patients with CD with a reassuring safety profile. The subcutaneous induction seems to be superior to the intravenous one.
DOI: 10.6084/m9.figshare.11460570.v1
title: Effectiveness and safety of Ustekinumab for the treatment of Crohn’s disease in real-life experiences: a meta-analysis of observational studies

description: <b>Background</b>: The aim of this meta-analysis was to estimate the effectiveness and safety of Ustekinumab in Crohn’s disease (CD) reported by observational studies. <b>Research design and methods</b>: PubMed/Medline and Embase were systematically searched through September 2019. Only real-life observational studies were included. <b>Results</b>: Thirteen studies comprising 1450 patients met the inclusion criteria. Ustekinumab was administered subcutaneously at induction among 7 studies, while in 6 studies the intravenous formulation was used. At induction (8–16 weeks), the pooled estimate rates of clinical response and remission were 56% (95% CI: 43-68%; range: 16–94%; I<sup>2</sup> = 94%) and 34% (95% CI: 25–45%; range: 15–58%; I<sup>2</sup> = 90%), respectively. The rate of clinical response was higher among studies which employed the subcutaneous compared with the intravenous induction (68% vs. 38%, p = 0.01). At maintenance, the pooled estimate rates of clinical response, clinical remission, endoscopic response, and endoscopic remission were 62% (95% CI: 50-73%; range: 42–89%; I<sup>2</sup> = 89%), 40% (95% CI: 28–54%; range: 26–73%; I<sup>2</sup> = 90%), 56% (95% CI: 37-73%; range: 20–77%; I<sup>2</sup> = 87%), and 19% (95% CI: 11-30%; range: 7–31%; I<sup>2</sup> = 67%), respectively. <b>Conclusions</b>: Ustekinumab is an effective treatment in patients with CD with a reassuring safety profile. The subcutaneous induction seems to be superior to the intravenous one.
DOI: 10.6084/m9.figshare.11460252
title: Temperature and CO2 levels in coral reef ecosystem experiments. from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: Experimental levels for temperatrue change and pCO2 from studies on coral reef organisms. Data was used to create Fig. 2b-c. Data was from Hughes et al. 2017
DOI: 10.6084/m9.figshare.11460255
title: Reference information and experimental information from global change studies on coral reef organisms from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: Infomation on temperatrue, CO2, and references are on separate sheets. Data was originally from Hughes et al. 2017, with additional data. Data was used to crate panels in Fig. 2.
DOI: 10.6084/m9.figshare.11460252.v1
title: Temperature and CO2 levels in coral reef ecosystem experiments. from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: Experimental levels for temperatrue change and pCO2 from studies on coral reef organisms. Data was used to create Fig. 2b-c. Data was from Hughes et al. 2017
DOI: 10.6084/m9.figshare.11460255.v1
title: Reference information and experimental information from global change studies on coral reef organisms from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: Infomation on temperatrue, CO2, and references are on separate sheets. Data was originally from Hughes et al. 2017, with additional data. Data was used to crate panels in Fig. 2.
DOI: 10.6084/m9.figshare.11460246
title: Coral reef regional temperature projections. from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: Temperature pojections for each croal reef region for each RCP. Data was used to create Fig. 2e. Data is from IPCC Table SM30-4
DOI: 10.6084/m9.figshare.11460249
title: IPCC CO2 to temperature relationship from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: RCP projections for the global ocean and temperatuer projections for the main ocean basins. Data was used to create Fig. 2a. Data is from IPCC Table SM30-4
DOI: 10.6084/m9.figshare.11460249.v1
title: IPCC CO2 to temperature relationship from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: RCP projections for the global ocean and temperatuer projections for the main ocean basins. Data was used to create Fig. 2a. Data is from IPCC Table SM30-4
DOI: 10.6084/m9.figshare.11460246.v1
title: Coral reef regional temperature projections. from A framework for experimental scenarios of global change in marine systems using coral reefs as a case study

description: Temperature pojections for each croal reef region for each RCP. Data was used to create Fig. 2e. Data is from IPCC Table SM30-4
DOI: 10.6084/m9.figshare.11460231
title: Table S2 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: Observational records of spawning dates in three reef locations
DOI: 10.6084/m9.figshare.11460234
title: ESM 1 from Dynamics of the energy seascape can explain intra-specific variations in sea-crossing behaviour of soaring birds

description: Metadata of bio-logging data for adult honey buzzards Pernis apivorus breeding in Finland.
DOI: 10.6084/m9.figshare.11460231.v1
title: Table S2 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: Observational records of spawning dates in three reef locations
DOI: 10.6084/m9.figshare.11460225
title: Table S1 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: Observational records of the first spawning dates in seven reef locations
DOI: 10.6084/m9.figshare.11460219
title: Table S4 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: Results of linear mix models (LMMs) of the effects of environmental parameters on the variation in spawning day deviation from full moon.
DOI: 10.6084/m9.figshare.11460222
title: Table S3 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: A list of information for environmental parameters obtained online.
DOI: 10.6084/m9.figshare.11460225.v1
title: Table S1 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: Observational records of the first spawning dates in seven reef locations
DOI: 10.6084/m9.figshare.11460219.v1
title: Table S4 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: Results of linear mix models (LMMs) of the effects of environmental parameters on the variation in spawning day deviation from full moon.
DOI: 10.6084/m9.figshare.11460222.v1
title: Table S3 from Environmental factors explain spawning day deviation from full moon in the scleractinian coral <i>Acropora</i>

description: A list of information for environmental parameters obtained online.
DOI: 10.6084/m9.figshare.11460213
title: Functional response database from Predator type influences the frequency of functional responses to prey in marine habitats

description: The functional response of a consumer to a gradient of resource density is a widespread and consistent framework used to quantify the importance of consumption to population dynamics and stability. Within benthic marine ecosystems, both crustaceans and fishes can provide strong top-down pressure on prey populations. Taxon-specific differences in biomechanics or habitat use, among other factors, may lead to variable functional response forms or parameter values (attack rate, handling time). Based on a review of 189 individual functional response fits, we find that these predator guilds differ in their frequency distribution of functional response types, with crustaceans exhibiting nearly double the proportion of sigmoidal, density-dependent functional responses (Holling type III) as predatory fishes. The implications of this finding for prey population stability are significant because type III responses allow for prey persistence while type II responses are de-stabilizing and can lead to extinction. Comparing per capita predation rates across diverse taxa can provide integrative insights into predatory effects and the ability of predation to drive community structure.
DOI: 10.6084/m9.figshare.11460213.v1
title: Functional response database from Predator type influences the frequency of functional responses to prey in marine habitats

description: The functional response of a consumer to a gradient of resource density is a widespread and consistent framework used to quantify the importance of consumption to population dynamics and stability. Within benthic marine ecosystems, both crustaceans and fishes can provide strong top-down pressure on prey populations. Taxon-specific differences in biomechanics or habitat use, among other factors, may lead to variable functional response forms or parameter values (attack rate, handling time). Based on a review of 189 individual functional response fits, we find that these predator guilds differ in their frequency distribution of functional response types, with crustaceans exhibiting nearly double the proportion of sigmoidal, density-dependent functional responses (Holling type III) as predatory fishes. The implications of this finding for prey population stability are significant because type III responses allow for prey persistence while type II responses are de-stabilizing and can lead to extinction. Comparing per capita predation rates across diverse taxa can provide integrative insights into predatory effects and the ability of predation to drive community structure.
DOI: 10.6084/m9.figshare.11459523
title: Sexdifferencesinchildrenbrain

description: Sex difference data
DOI: 10.6084/m9.figshare.11459523.v1
title: Sexdifferencesinchildrenbrain

description: Sex difference data
DOI: 10.6084/m9.figshare.11459247
title: filtered YN60

description: Genome-wide scan of selection signatures in Dehong humped cattle for heat tolerance and disease resistance
DOI: 10.6084/m9.figshare.11459523.v3
title: Sexdifferencesinchildrenbrain

description: Sex difference data
DOI: 10.6084/m9.figshare.11459523.v2
title: Sexdifferencesinchildrenbrain

description: Sex difference data
DOI: 10.6084/m9.figshare.11459247.v2
title: filtered YN60

description: Genome-wide scan of selection signatures in Dehong humped cattle for heat tolerance and disease resistance
DOI: 10.6084/m9.figshare.11459247.v1
title: Genome-wide scan of selection signatures in Dehong humped cattle for heat tolerance and disease resistance

description: genotypic datas of Yunnan three native cattle
DOI: 10.6084/m9.figshare.11458107
title: MOESM2 of Fault model of the 2012 doublet earthquake, near the up-dip end of the 2011 Tohoku-Oki earthquake, based on a near-field tsunami: implications for intraplate stress state

description: Additional file 2: Dataset S1. The TPG data used in this study.
DOI: 10.6084/m9.figshare.11458107.v1
title: MOESM2 of Fault model of the 2012 doublet earthquake, near the up-dip end of the 2011 Tohoku-Oki earthquake, based on a near-field tsunami: implications for intraplate stress state

description: Additional file 2: Dataset S1. The TPG data used in this study.
DOI: 10.6084/m9.figshare.11457906
title: Anexo D. Agenda grupo focal con beneficiarios del PCA

description: Agenda para conducir grupo focal con beneficiarios del PCA.
DOI: 10.6084/m9.figshare.11457768
title: Anexo A. Encuesta a beneficiarios del PCA

description: Encuesta a beneficiarios para la construcción de tipologías.
DOI: 10.6084/m9.figshare.11457894
title: Gene database of Aeromonas hydrophila ATCC 7966

description: Present in both freshwater and brackish water, <i>Aeronomas hydrophila</i> is a human pathogen that is the causative agent for a variety of conditions such as gastroenteritis and septicaemia. The bacterium possesses a set of cell surface appendages that makes it particularly concerning as a pathogen. Chief amongst this is a Type II secretion system that enables the injection of aerolysin toxin into host cells. Notwithstanding this, <i>A. hydrophila</i> also possesses Type IV pilli useful for attachment to cells and extracellular proteases that can cause tissue damage. This work sought to provide some fundamental information of <i>A. hydrophila </i>ATCC 7966 by parsing the GenBank annotated genome file of the bacterium (GenBank accession number: NCBI Reference Sequence: NC_008570.1). Using an in-house MATLAB software, a gene database for the bacterium comprising gene identifier, gene function and gene sequence was built. Information presented in this dataset should find use in a variety of fundamental microbiological studies seeking to understand the pathogenesis mechanism of <i>A. hydrophila</i> through generating specific mutants via genome editing.<br><br>
DOI: 10.6084/m9.figshare.11457906.v1
title: Anexo D. Agenda grupo focal con beneficiarios del PCA

description: Agenda para conducir grupo focal con beneficiarios del PCA.
DOI: 10.6084/m9.figshare.11457768.v1
title: Anexo A. Encuesta a beneficiarios del PCA

description: Encuesta a beneficiarios para la construcción de tipologías.
DOI: 10.6084/m9.figshare.11457762
title: Anexo B. Consentimiento informado

description: Modelo de consentimiento informado para la ejecución de investigaciones sociales.
DOI: 10.6084/m9.figshare.11457759
title: Anexo C. Guía de entrevista a expertos vinculados al PCA

description: Guía de entrevista usada para la tipificación de productores agroecológicos.
DOI: 10.6084/m9.figshare.11457759.v1
title: Anexo C. Guía de entrevista a expertos vinculados al PCA

description: Guía de entrevista usada para la tipificación de productores agroecológicos.
DOI: 10.6084/m9.figshare.11457762.v1
title: Anexo B. Consentimiento informado

description: Modelo de consentimiento informado para la ejecución de investigaciones sociales.
DOI: 10.6084/m9.figshare.11455851
title: Temp12k all data

description: netCDF file containing reconstruction data for all methods, both for global and latitude-zone means.
DOI: 10.6084/m9.figshare.11455851.v1
title: Temp12k all data

description: netCDF file containing reconstruction data for all methods, both for global and latitude-zone means.
DOI: 10.6084/m9.figshare.11455848
title: Temp12k multi-method median & percentiles

description: CSV file containing the multi-method median values as well as 2.5 and 97.5 percentiles for the global mean and latitudinal-zone means.
DOI: 10.6084/m9.figshare.11455848.v1
title: Temp12k multi-method median & percentiles

description: CSV file containing the multi-method median values as well as 2.5 and 97.5 percentiles for the global mean and latitudinal-zone means.
DOI: 10.6084/m9.figshare.11455830
title: Temp12k ensembles PAI

description: Zip contains seven CSV files, one for each of the six latitude zones and one for global based on the Pairwise Comparison (PAI) method. temp12k_[method]_globalmean.csv: These are CSV files containing global-mean temperature reconstructions for all 500 ensemble members of a given method, as in the netCDF file above. The first column is age, followed by the global-mean temperature reconstruction for all 500 ensemble members. temp12k_[method]_latband_[region].csv. These files are structured the same way as the "globalmean" files above, but contain values for latitude-zone means.
DOI: 10.6084/m9.figshare.11455845
title: ReadMe

description: Description of files containing Holocene temperature reconstructions.