cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17373027
title: Taking a walk through time: aversive memory re-experiencing may be linked to spatio-temporal distance

description: Individuals with posttraumatic stress disorder (PTSD) often report intrusive memories that appear to lack the appropriate spatio-temporal context. We examined whether focusing on the spatio-temporal context of aversive autobiographical memories reduces negative emotions, appraisals, and re-experiencing symptoms. We recruited 109 healthy adults and had them rate emotionality, vividness, and re-experiencing of an aversive autobiographical memory. Furthermore, we assessed automatic associations of idiosyncratic memory triggers with the concepts ‘past’ vs. ‘now’, and self-reported sense of memory closure and distancing. To manipulate spatio-temporal memory (re-)organization, the experimental group (<i>n</i> = 53) performed a lifeline exercise in virtual reality (VR), where participants symbolically placed memory triggers along a path representing their own personal life story. The control group (<i>n</i> = 56) completed a non-personalized VR task. We found a marked decrease in negative emotions, negative appraisals, and re-experiencing in the following week, but on average, the lifeline exercise was not superior to the control condition. However, those in the lifeline group with stronger trigger-past associations subsequently exhibited a more pronounced reduction in re-experiencing. Also, participants with a higher subjective sense of memory distancing reported less re-experiencing. The findings lend tentative support for theoretical assumptions about PTSD, but the potential causal role of automatic associations with spatio-temporal information remains to be clarified. We tested a VR lifeline exercise to alter spatio-temporal associations and intrusions of aversive autobiographical memories.This was not superior to a non-personalized control group, but temporal associations and memory distancing predicted reduced re-experiencing. We tested a VR lifeline exercise to alter spatio-temporal associations and intrusions of aversive autobiographical memories. This was not superior to a non-personalized control group, but temporal associations and memory distancing predicted reduced re-experiencing.
DOI: 10.6084/m9.figshare.17373027.v1
title: Taking a walk through time: aversive memory re-experiencing may be linked to spatio-temporal distance

description: Individuals with posttraumatic stress disorder (PTSD) often report intrusive memories that appear to lack the appropriate spatio-temporal context. We examined whether focusing on the spatio-temporal context of aversive autobiographical memories reduces negative emotions, appraisals, and re-experiencing symptoms. We recruited 109 healthy adults and had them rate emotionality, vividness, and re-experiencing of an aversive autobiographical memory. Furthermore, we assessed automatic associations of idiosyncratic memory triggers with the concepts ‘past’ vs. ‘now’, and self-reported sense of memory closure and distancing. To manipulate spatio-temporal memory (re-)organization, the experimental group (<i>n</i> = 53) performed a lifeline exercise in virtual reality (VR), where participants symbolically placed memory triggers along a path representing their own personal life story. The control group (<i>n</i> = 56) completed a non-personalized VR task. We found a marked decrease in negative emotions, negative appraisals, and re-experiencing in the following week, but on average, the lifeline exercise was not superior to the control condition. However, those in the lifeline group with stronger trigger-past associations subsequently exhibited a more pronounced reduction in re-experiencing. Also, participants with a higher subjective sense of memory distancing reported less re-experiencing. The findings lend tentative support for theoretical assumptions about PTSD, but the potential causal role of automatic associations with spatio-temporal information remains to be clarified. We tested a VR lifeline exercise to alter spatio-temporal associations and intrusions of aversive autobiographical memories.This was not superior to a non-personalized control group, but temporal associations and memory distancing predicted reduced re-experiencing. We tested a VR lifeline exercise to alter spatio-temporal associations and intrusions of aversive autobiographical memories. This was not superior to a non-personalized control group, but temporal associations and memory distancing predicted reduced re-experiencing.
DOI: 10.6084/m9.figshare.19519944.v1
title: Online training for evidence-based child trauma treatment: evaluation of the German language TF-CBT-Web

description: Evidence-based trauma-focused interventions for treating PTSD in children and youth are barely used in practice. Web-based training has proven to be an effective way of transferring knowledge to healthcare professionals. TF-CBT Web is a web-based training programme designed to foster the dissemination of Trauma Focused Cognitive Behavioural Therapy (TF-CBT) for children and youth, and is run by the Medical University of South Carolina. This paper describes the characteristics of healthcare professionals who registered for the adapted German language version of TF-CBT Web. It evaluates the effectiveness and user friendliness of the programme. : Similar to the TF-CBT treatment manual, the German language TF-CBT Web contains 12 modules. Between 2018 and 2020, 4,020 users registered for the programme. During the registration process users provided demographic information. The knowledge of users regarding the TF-CBT components was assessed via pre-tests and post-tests in each module. The programme was accessed by a sample of mostly German users with varying professional health care backgrounds and a wide-ranging spread of work experience. The results indicated a significant knowledge gain and high rates of user satisfaction with the programme. In summary, the results of this study suggested that web-based training is an effective and well-accepted method for knowledge gain in trauma-focused interventions. Future research should evaluate the actual application of the taught methods in clinical practice. Children and adolescents with PTSD require trauma-focused treatment. However, evidence-based interventions for this patient population are barely used. Therefore, it is necessary to expand professional training for the treatment of traumatised children and adolescents.Our evaluation showed the effectiveness and feasibility of a web-based training programme for mental health practitioners in an evidence-based treatment for children and youth with PTSD (TF-CBT). Results show a significant knowledge gain of users who participate in the web-based training programme.The user satisfaction survey also revealed that users found the modus and content of the web-based training applicable and relevant for their clinical practice. Children and adolescents with PTSD require trauma-focused treatment. However, evidence-based interventions for this patient population are barely used. Therefore, it is necessary to expand professional training for the treatment of traumatised children and adolescents. Our evaluation showed the effectiveness and feasibility of a web-based training programme for mental health practitioners in an evidence-based treatment for children and youth with PTSD (TF-CBT). Results show a significant knowledge gain of users who participate in the web-based training programme. The user satisfaction survey also revealed that users found the modus and content of the web-based training applicable and relevant for their clinical practice.
DOI: 10.6084/m9.figshare.20025742
title: Skills Training in Affective and Interpersonal Regulation Narrative Therapy for women with ICD-11 complex PTSD related to childhood abuse in Japan: a pilot study

description: Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy (SNT) has shown efficacy in alleviating symptoms of posttraumatic stress disorder (PTSD) and improving emotion regulation and interpersonal skills among individuals with complex trauma, such as childhood abuse. Although this therapy is expected to be effective for patients with complex PTSD (CPTSD), no study has directly assessed diagnostic and symptom outcomes. Moreover, the potential of therapy to achieve good outcomes in non-Western countries remains unclear. This pilot study examined the feasibility, safety, and outcomes of SNT for CPTSD among women with a history of childhood abuse in a Japanese clinical setting. Ten women aged 21–54 years (<i>M</i> = 29.1 years) with childhood-abuse-related ICD-11 CPTSD were enrolled in this study. The International Trauma Interview and International Trauma Questionnaire were administered to diagnose CPTSD and assess its severity. Symptoms of dissociation and depression, difficulties in emotion regulation and interpersonal relationships, quality of life, and negative cognitions were assessed pretreatment, midtreatment (after the STAIR phase), and immediately posttreatment (after the Narrative Therapy phase), in addition to 3 months after treatment. Seven of the 10 participants completed the treatment. The therapists’ adherence to the therapy protocol was 96.4%, ranging from 93.6% to 100% across therapists. Serious adverse events were not observed. Among the seven completers, six at posttreatment and all at follow-up no longer met CPTSD diagnosis. Exploratory analyses using the linear mixed-effects model showed significant improvements at posttreatment and follow-up for almost all the variables. The results provide preliminary evidence for the feasibility and safety of SNT for CPTSD in a Japanese clinical setting. This study is the first to report the use of SNT for individuals diagnosed with ICD-11 CPTSD using reliable clinician and self-report measures. This study examined the feasibility and safety of STAIR Narrative Therapy for women with ICD-11 CPTSD related to childhood abuse in a Japanese clinical setting.High therapy adherence was observed.No serious adverse events occurred. This study examined the feasibility and safety of STAIR Narrative Therapy for women with ICD-11 CPTSD related to childhood abuse in a Japanese clinical setting. High therapy adherence was observed. No serious adverse events occurred.
DOI: 10.6084/m9.figshare.19248223
title: A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda

description: Systemic oppression, particularly towards sexual minorities, continues to be deeply rooted in the bedrock of many societies globally. Experiences with minority stressors (e.g. discrimination, hate-crimes, internalized homonegativity, rejection sensitivity, and microaggressions or everyday indignities) have been consistently linked to adverse mental health outcomes. Elucidating the neural adaptations associated with minority stress exposure will be critical for furthering our understanding of how sexual minorities become disproportionately affected by mental health burdens. Following PRISMA-guidelines, we systematically reviewed published neuroimaging studies that compared neural dynamics among sexual minority and heterosexual populations, aggregating information pertaining to any measurement of minority stress and relevant clinical phenomena. Only 1 of 13 studies eligible for inclusion examined minority stress directly, where all other studies focused on investigating the neurobiological basis of sexual orientation. In our narrative synthesis, we highlight important themes that suggest minority stress exposure may be associated with decreased activation and functional connectivity within the default-mode network (related to the sense-of-self and social cognition), and summarize preliminary evidence related to aberrant neural dynamics within the salience network (involved in threat detection and fear processing) and the central executive network (involved in executive functioning and emotion regulation). Importantly, this parallels neural adaptations commonly observed among individuals with posttraumatic stress disorder (PTSD) in the aftermath of trauma and supports the inclusion of insidious forms of trauma related to minority stress within models of PTSD. Taken together, minority stress may have several shared neuropsychological pathways with PTSD and stress-related disorders. Here, we outline a detailed research agenda that provides an overview of literature linking sexual minority stress to PTSD and insidious trauma, moral affect (including shame and guilt), and mental health risk/resiliency, in addition to racial, ethnic, and gender related minority stress. Finally, we propose a novel <b>minority mosaic framework</b> designed to inform future directions of minority stress neuroimaging research from an intersectional lens. Minority stress exposure may be associated with alterations within intrinsic connectivity networks.There currently exists a limited number of neuroimaging studies directly investigating the neural correlates of minority stress.Here, we propose a novel <b>minority mosaic framework</b>. Minority stress exposure may be associated with alterations within intrinsic connectivity networks. There currently exists a limited number of neuroimaging studies directly investigating the neural correlates of minority stress. Here, we propose a novel <b>minority mosaic framework</b>.
DOI: 10.6084/m9.figshare.19248223.v1
title: A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda

description: Systemic oppression, particularly towards sexual minorities, continues to be deeply rooted in the bedrock of many societies globally. Experiences with minority stressors (e.g. discrimination, hate-crimes, internalized homonegativity, rejection sensitivity, and microaggressions or everyday indignities) have been consistently linked to adverse mental health outcomes. Elucidating the neural adaptations associated with minority stress exposure will be critical for furthering our understanding of how sexual minorities become disproportionately affected by mental health burdens. Following PRISMA-guidelines, we systematically reviewed published neuroimaging studies that compared neural dynamics among sexual minority and heterosexual populations, aggregating information pertaining to any measurement of minority stress and relevant clinical phenomena. Only 1 of 13 studies eligible for inclusion examined minority stress directly, where all other studies focused on investigating the neurobiological basis of sexual orientation. In our narrative synthesis, we highlight important themes that suggest minority stress exposure may be associated with decreased activation and functional connectivity within the default-mode network (related to the sense-of-self and social cognition), and summarize preliminary evidence related to aberrant neural dynamics within the salience network (involved in threat detection and fear processing) and the central executive network (involved in executive functioning and emotion regulation). Importantly, this parallels neural adaptations commonly observed among individuals with posttraumatic stress disorder (PTSD) in the aftermath of trauma and supports the inclusion of insidious forms of trauma related to minority stress within models of PTSD. Taken together, minority stress may have several shared neuropsychological pathways with PTSD and stress-related disorders. Here, we outline a detailed research agenda that provides an overview of literature linking sexual minority stress to PTSD and insidious trauma, moral affect (including shame and guilt), and mental health risk/resiliency, in addition to racial, ethnic, and gender related minority stress. Finally, we propose a novel <b>minority mosaic framework</b> designed to inform future directions of minority stress neuroimaging research from an intersectional lens. Minority stress exposure may be associated with alterations within intrinsic connectivity networks.There currently exists a limited number of neuroimaging studies directly investigating the neural correlates of minority stress.Here, we propose a novel <b>minority mosaic framework</b>. Minority stress exposure may be associated with alterations within intrinsic connectivity networks. There currently exists a limited number of neuroimaging studies directly investigating the neural correlates of minority stress. Here, we propose a novel <b>minority mosaic framework</b>.
DOI: 10.5281/zenodo.7628633
title: brotogeris_chrysoptera_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.7628632
title: brotogeris_chrysoptera_spades_01.fasta.gz

description: .
DOI: 10.6084/m9.figshare.22006127.v1
title: Supplementary Material for: Delayed diagnosis of indolent systemic mastocytosis as the cause of unexplained skin rash: a case report.

description: Mastocytosis is a heterogeneous group of disorders in which mast cells exhibit clonal proliferation that infiltrates one or more organs. In cutaneous mastocytosis, the mast cells infiltrate the skin only, whereas systemic mastocytosis is diagnosed when at least one extra-cutaneous site is involved with or without the skin being affected. Given the rarity of mastocytosis and the fact that skin rash can be a manifestation of different conditions and many clinicians aren’t familiar with this disorder, an accurate diagnosis may be delayed. We report a delayed diagnosis of indolent systemic mastocytosis in a 40-year-old gentleman who had been complaining of an unexplained skin rash for 6 years.
DOI: 10.1184/r1/22049177
title: Selectivity for food in human ventral visual cortex

description: The fLoc localizer by Stigliani et al. (Journal of Neuroscience 2015) was adapted to include a food condition that was constructed by identifying images of food items from different categories and with different shapes, converting them to grayscale and superposing them on the scrambled images from the fLoc localizer. Other conditions included faces, bodies, places and written words. <br> The current dataset is published as part of the following publication: <br> Jain, N., Wang, A., Henderson, M. M., Lin, R., Prince, J. S., Tarr, M. J., & Wehbe, L. (2023). Food for thought: selectivity for food in human ventral visual cortex. <em>Communications Biology. </em> <br> Please see the paper above for more detail and cite it if the dataset is used.
DOI: 10.1184/r1/22049177.v1
title: Selectivity for food in human ventral visual cortex

description: The fLoc localizer by Stigliani et al. (Journal of Neuroscience 2015) was adapted to include a food condition that was constructed by identifying images of food items from different categories and with different shapes, converting them to grayscale and superposing them on the scrambled images from the fLoc localizer. Other conditions included faces, bodies, places and written words. <br> The current dataset is published as part of the following publication: <br> Jain, N., Wang, A., Henderson, M. M., Lin, R., Prince, J. S., Tarr, M. J., & Wehbe, L. (2023). Food for thought: selectivity for food in human ventral visual cortex. <em>Communications Biology. </em> <br> Please see the paper above for more detail and cite it if the dataset is used.
DOI: 10.14272/wtitzhqmbfotbc-ocozrvbesa-n/chmo0000597
title: 19F nuclear magnetic resonance spectroscopy (19F NMR) ()
title: InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+

description: dataset for 19F nuclear magnetic resonance spectroscopy (19F NMR) 19F NMR (376 MHz, CDCl3, ppm) δ = -58.73.
DOI: 10.14272/wtitzhqmbfotbc-ocozrvbesa-n.1
title: (E)-N-(2-(3,3-diisopropyltriaz-1-en-1-yl)-3-(trifluoromethyl)benzyl)-3-methylbutanamide
title: InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+

description: This dataset contains experimental data from a sample (InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+). The datasets from the following experiments are available: 1H nuclear magnetic resonance spectroscopy (1H NMR) 19F nuclear magnetic resonance spectroscopy (19F NMR) infrared absorption spectroscopy (IR) mass spectrometry (MS) 13C nuclear magnetic resonance spectroscopy (13C NMR)
DOI: 10.14272/wtitzhqmbfotbc-ocozrvbesa-n/chmo0000630
title: infrared absorption spectroscopy (IR) ()
title: InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+

description: dataset for infrared absorption spectroscopy (IR) IR (ATR, ṽ) = 3284 (vw), 3076 (vw), 2959 (w), 2933 (w), 2870 (w), 1644 (m), 1599 (vw), 1587 (vw), 1545 (w), 1466 (w), 1446 (w), 1422 (s), 1403 (m), 1382 (w), 1366 (m), 1317 (vs), 1262 (w), 1225 (s), 1194 (w), 1147 (vs), 1127 (vs), 1097 (m), 1083 (m), 1031 (w), 923 (vw), 867 (vw), 777 (w), 746 (w), 731 (vw), 666 (vw), 605 (vw), 549 (vw), 513 (vw), 466 (vw) cm–1.
DOI: 10.14272/wtitzhqmbfotbc-ocozrvbesa-n/chmo0000470
title: mass spectrometry (MS) ()
title: InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+

description: dataset for mass spectrometry (MS) EI (m/z, 70 eV, 50 °C): 386 (2) [M]+, 258 (16), 241 (10), 226 (10), 215 (19), 200 (24), 175 (18), 159 (14), 155 (19), 100 (26), 85 (58), 72 (15), 69 (16), 60 (26), 57 (100).HRMS (C19H29ON4F3): Calcd 386.2288, Found 386.2289.
DOI: 10.14272/wtitzhqmbfotbc-ocozrvbesa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) ()
title: InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR) 13C NMR (100 MHz, Chloroform-d [77.0 ppm], ppm) δ = 171.9, 149.4, 133.8, 131.4, 126.1 (q, J = 5.7 Hz), 124.3, 124.1 (q, J = 273.6 Hz), 123.5 (q, J = 28.0 Hz), 49.3, 46.4, 46.3, 40.2, 26.1, 23.4 (2C), 22.5 (2C), 19.2 (2C). Impurities: methylene chloride and by-product (ca. 5% according to 1H NMR measurement). The yield has been adjusted accordingly.
DOI: 10.14272/wtitzhqmbfotbc-ocozrvbesa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) ()
title: InChI=1S/C19H29F3N4O/c1-12(2)10-17(27)23-11-15-8-7-9-16(19(20,21)22)18(15)24-25-26(13(3)4)14(5)6/h7-9,12-14H,10-11H2,1-6H3,(H,23,27)/b25-24+

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR) 1H NMR (500 MHz, Chloroform-d [7.27 ppm], ppm) δ = 7.60 (dd, J = 1.1 Hz, J = 7.8 Hz, 1H), 7.54 (d, J = 7.6 Hz, 1H), 7.18 (t, J = 7.8 Hz, 1H), 5.80 (br.s, 1H), 5.19 (sept, J = 6.9 Hz, 1H), 4.38 (d, J = 5.8 Hz, 2H), 4.05 (sept, J = 6.7 Hz, 1H), 2.16–2.08 (m, 1H), 2.01 (d, J = 7.0 Hz, 2H), 1.37 (d, J = 6.7 Hz, 6H), 1.29 (d, J = 7.0 Hz, 6H), 0.93 (d, J = 6.7 Hz, 6H). Impurities: methylene chloride (5.30 ppm) and by-product. The yield has been adjusted accordingly.