cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/0gxq1w
title: E2F1-Driven CENPM Expression Promotes Glycolytic Reprogramming and Tumorigenicity in Glioblastoma

description: Background: While historically linked to chromosome segregation, centromere proteins (CENPs) are increasingly implicated in cancer biology. Although other CENPs have been studied in various cancers, including Glioblastoma (GBM), the less-explored CENPM demonstrates intriguing potential to influence tumor cell proliferation, invasion, and metabolic reprogramming - crucial factors in GBM aggressiveness.
Methods: Initial insights into CENPM expression patterns in GBM were obtained through GEPIA database analysis (TCGA/GTEx datasets). Our in vitro model incorporated LN229 and U251 GBM cell lines. We modulated CENPM expression through shRNA-mediated knockdown and overexpression (pcDNA3.1 vectors), using Lipofectamine 2000 delivery. RT-qPCR and Western blotting assays quantified CENPM levels at mRNA and protein levels. GBM cell viability and proliferation were assessed via CCK-8 and EdU assays, respectively, while Transwell assays evaluated invasion. Changes in cellular metabolism were analyzed by measuring glucose consumption, lactate production, and ATP levels. To evaluate E2F1's regulatory impact on CENPM, we used luciferase reporter assays. Finally, an in vivo BALB/c nude mouse xenograft model helped us assess the effect of CENPM modulation on tumor growth.
Results: Our analysis demonstrated significant CENPM upregulation in GBM, confirmed by GEPIA and RT-qPCR, suggesting its potential as a therapeutic target. CENPM knockdown dramatically reduced GBM cell proliferation and invasion, accompanied by altered EMT marker expression. This highlights CENPM's central role in GBM progression. Conversely, CENPM overexpression promoted growth and EMT, further implicating it in aggressive tumor behavior. We observed CENPM's influence on glycolysis, with reduced activity following knockdown and increased activity with overexpression. Importantly, the glycolytic inhibitor 2-DG reversed these effects, hinting at glycolytic dependency in CENPM-modulated cells. We also established that E2F1 interacts with the CENPM promoter, representing a likely regulatory mechanism. Finally, in vivo studies confirmed that CENPM knockdown significantly hinders tumor growth, strongly supporting its critical role in GBM.
Conclusion: Our findings highlight a novel role for CENPM in promoting GBM progression through metabolic reprogramming and enhancing tumor cell invasion. The E2F1-CENPM axis emerges as a critical mediator of these processes, suggesting that targeting this interaction could offer a new therapeutic approach for GBM treatment.
DOI: 10.7910/dvn/0h4hg2
title: Replication Data for: 'Web of Power: How Elite Networks Shaped War and Politics in China'

description: The data and programs replicate tables and figures from "Web of Power: How Elite Networks Shaped War and Politics in China", by Bai, Jia, and Yang. Please see the README file for additional details.
DOI: 10.7910/dvn/0hdofv
title: A15_28084.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/131032d7-8c29-4a9d-8ffd-a4bb384ca729'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/131032d7-8c29-4a9d-8ffd-a4bb384ca729
DOI: 10.7910/dvn/0huxoj
title: Geospatial dataset of Gaza targeting polygons publicized by the IDF on December 1, 2023

description: This dataset is intended to make available in a timely digital format the targeting zone polygons used by the IDF in Gaza beginning on December 1, 2023. These are broadly publicized by the IDF and embedded in their openly published web site, but not in a form that would allow maximum uptake by the affected public, humanitarian agencies and the research community. This dataset aims to rapidly allow a broader audience to utilize this information, whether for active use or as a longer-term record.
description: See deposited PDF document on the purpose, background, intended use, and notes on/limitations of this dataset
DOI: 10.7910/dvn/0i1eyg
title: Replication Data for: Reinvestigating the Environmental Kuznets Curve Hypothesis of Carbon Emissions in 214 Countries: From Traditional Variables to Emerging Variables

description: Data are obtained from multi-dimensional sources including the World Bank, ITU, IFR, ICRG and other sources. The data structure is an unbalanced panel of 214 countries from 1960 to 2020. Country names are represented by ISO3 country codes. The data includes two explained variables: carbon emissions and per capita carbon emissions, as well as 13 explanatory variables including per capita GDP.
DOI: 10.7910/dvn/0epjad
title: GBMI Kianggeh

description: GBMI Dataset for Kianggeh, Brunei
DOI: 10.7910/dvn/0eui4b
title: A16_31623.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/709879b6-5454-41c6-b965-00d579b45822'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/709879b6-5454-41c6-b965-00d579b45822
DOI: 10.7910/dvn/0f2fj0
title: Minnesota Twins Political Survey Data

description: The Minnesota Twins Political Survey was designed to allow researchers to explore genetic and environmental sources of variance on a wide range of political traits. The data is originally located at http://www.unl.edu/polphyslab/data and is being reposted here for wider dissemination. 

The data employed in this project were collected with the financial support of the National Science Foundation in the form of SES-0721378, PI: John R. Hibbing; Co-PIs: John R. Alford, Lindon J. Eaves, Carolyn L. Funk, Peter K. Hatemi, and Kevin B. Smith, and with the cooperation of the Minnesota Twin Registry at the University of Minnesota, Robert Krueger and Matthew McGue, Directors."
DOI: 10.7910/dvn/0g61mh
title: Data for The Clinical Utility of Resistance Training for Improving Cardiovascular Disease Risk in Post-Menopausal Women

description: This project will test the effectiveness of a practical, progressive resistance training regimen for lowering numerous CVD risk factors compared to both aerobic training and no exercise in post-menopausal women.
DOI: 10.7910/dvn/0gl9pu
title: TAPS Data, August 2017

description: TAPS data, August 2017
DOI: 10.7910/dvn/0gpryw
title: Spanish General Elections
title: SEA Database - General
title: Spanish Electoral Archive Database - General

description: The main objective of this dataset is to offer analysts and scholars of the electoral phenomenon and society in general a centralized place where to find, in an organized and homogeneous way, the results recorded in the general elections processes held in Spain since 1977.
description: See details in Excel files.
DOI: 10.7910/dvn/0het2u
title: ChatGPT data

description: ChatGPT dataset
DOI: 10.7910/dvn/0hfjyi
title: A15_30180.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/84ff1c30-f9b0-407b-8ebc-f85a9e8606bf'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/84ff1c30-f9b0-407b-8ebc-f85a9e8606bf
DOI: 10.7910/dvn/0hnecy
title: Orchid Flowers Dataset

description: This dataset contains 7156 images of orchid flowers and consists of 156 orchid species. Most of the images are Flickr images under the Creative Commons license and some of the images are obtained from websites like Go Botany (Native Plant Trust), Encyclopedia of Life (EoL), etc. Different from other flower datasets, besides containing images, this dataset also containing flower's characteristics. The dataset can be used for multi-class classification and also for multi-label classification
DOI: 10.7910/dvn/0hptq2
title: A11_20666.JPG

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/e6e408c2-29e7-43f4-bb9f-3ce9da54c9fe'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/e6e408c2-29e7-43f4-bb9f-3ce9da54c9fe
DOI: 10.7910/dvn/0eoxnw
title: Replication code for "The Missing Home Buyers: Regional Heterogeneity and Credit Contractions"

description: Code for "The Missing Home Buyers: Regional Heterogeneity and Credit Contractions," forthcoming in the Review of Financial Studies.
DOI: 10.7910/dvn/0eur7l
title: The investigation of investor behaviors in terms of behavioral finance and investor psychology: The case of Sultanhisar district

description: Today, one way of understanding the activity and inactivity of the world of finance passes through understanding human because the investment decisions that individuals make or not are completely related to human, that is to say, to themselves. In this sense, the investment decisions that individuals have made or not are available for research in the field of behavioral finance and striking results have been revealed. Within this context, the aim of this study was to reveal the investor profiles of the farmers working in Sultanhisar district of Aydın province, the distinguished province of Aegean Region and to try to determine which psychological factors they were influenced by while making investment decisions. As a result of the study, investor profiles were revealed and of investor psychological bias, acquaintance delusion, overconfidence delusion, attribution delusion, representation heuristic, predisposition effect, and over-optimism delusion was used. At the end of the research, it was determined that there were differences among the sub-dimensions used and suggestions were presented.
DOI: 10.7910/dvn/0euw82
title: Replication Data for: Carbon emissions reductions from Indonesia's Moratorium on forest concessions are cost-effective yet contribute little to Paris pledges

description: International initiatives for reducing carbon emissions from deforestation and forest degradation (REDD+) could make critical, cost-effective contributions to tropical countries’ Nationally Determined Contributions. Norway, a key donor of such initiatives, had a REDD+ partnership with Indonesia, offering results-based payments in exchange for emissions reductions calculated against a historical baseline. Central to this partnership was an area-based Moratorium on new oil palm, timber and logging concessions in primary and peatland forests. We evaluate the effectiveness of the Moratorium between 2011 and 2018 by applying a matched triple difference strategy to a unique panel dataset. Treated dryland forest inside Moratorium areas retained at most, an average of 0.65% higher forest cover compared to untreated dryland forest outside the Moratorium. By contrast, carbon-rich peatland forest was unaffected by the Moratorium. Cumulative avoided dryland deforestation from 2011 until 2018 translates into 67.8-86.9 million tons of emissions reductions, implying an effective carbon price below Norway’s US$5 per ton price. Based on Norway’s price, our estimated cumulative emissions reductions are equivalent to a payment of US$339-434.5 million. Annually, our estimates suggest a 3-4 percent contribution to Indonesia’s NDC commitment of a 29% emissions reduction by 2030. Despite the Indonesia-Norway partnership ending in 2021, reducing emissions from deforestation remains critical for meeting this commitment. Future area-based REDD+ initiatives could build on the Moratorium’s outcomes by reforming its incentives and institutional arrangements, particularly in peatland forest areas.
DOI: 10.7910/dvn/0f2ldx
title: A16_31539.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/3dc7f0c3-f23f-48d8-8ff9-49c1fc574727'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/3dc7f0c3-f23f-48d8-8ff9-49c1fc574727
DOI: 10.7910/dvn/0fndhw
title: Reproduction files for: "Has Trust in the European Parliament Polarized?"

description: This repository contains code and data to reproduce the analyses in the study "Has Trust in the European Parliament Polarized?". Please see "INSTRUCTIONS.txt" for instructions to reproduce the study.
DOI: 10.7910/dvn/0gbc2t
title: A15_29633.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/75959fa4-d37d-444b-91cd-9235b68d6666'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/75959fa4-d37d-444b-91cd-9235b68d6666
DOI: 10.7910/dvn/0gea3k
title: us_10703_15_pamp003

description: Some Questions and Answers
description: URN-3:FHCL.HOUGH:100949698
DOI: 10.7910/dvn/0ghdh4
title: Replication Data for: Measurements, gas/particle partitioning, and sources of non-polar organic molecular markers at a suburban site in the west Yangtze River Delta, China

description: Datasets of Figures in the manuscript and supplementary information
DOI: 10.7910/dvn/0gkbgt
title: US 2020 General Official Raw Election Results Files
title: Raw Files of Final Results from all 56 US Electoral Jurisdictions

description: &lt;p&gt;Official election results for each of the 50 states, the five major territories and the District of Columbia) for the 2020 General Election. Some files provide results at the precinct level; others have results as the county level (or equivalent for jurisdictions that do not report by county). Contests include all federal contests, most statewide and most state legislative contests. &lt;/p&gt;

&lt;p&gt;These are the original files from the boards of elections or, where the board of elections provided only pdf or html, the files contain data copied directly en masse from the original files.&lt;/p&gt;
DOI: 10.7910/dvn/0he9n5
title: A98_9885.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/f3f3f432-6d38-8f43-6948-a37aa18d048f'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/f3f3f432-6d38-8f43-6948-a37aa18d048f
DOI: 10.7910/dvn/0hgivk
title: A15_29411.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/e8b7a8eb-93e1-4963-ba2a-6f5e24e00433'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/e8b7a8eb-93e1-4963-ba2a-6f5e24e00433
DOI: 10.7910/dvn/0kd2zw
title: A97_8242.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/c82aa825-e7ce-735d-0f08-ca1538c7b69a'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/c82aa825-e7ce-735d-0f08-ca1538c7b69a
DOI: 10.7910/dvn/0kfahe
title: A15_30173.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/6dd5d526-d9d5-4655-a74e-8053d69b2669'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/6dd5d526-d9d5-4655-a74e-8053d69b2669
DOI: 10.7910/dvn/0evfgn
title: Executive Agreements Database, Statement Regarding Agreement Between The United States, The United Kingdom and The Turks and Caicos Islands Amending The Memorandum of Understanding To Establish In The Turks and Caicos Islands A Processing Facility To Determine The Refugee Status Of Boat People From Haiti Signed At Grand Turk June 18, 1994 Effected By Exchange Of Letters Act Grand Turk and London July 13, 1994

description: KAV 3949

cover memo
DOI: 10.7910/dvn/0feafr
title: Data Covid-19 of Indonesia

description: Data Covid-19 of Indonesia
DOI: 10.7910/dvn/0febdi
title: Replication data for Beine, Boucher, Burgoon, Crock, Gest, Hiscox, McGovern, Rapoport, Schaper, Thielemann. (2016). Comparing immigration policies: an overview from the IMPALA database. INTERNATIONAL MIGRATION REVIEW, 50(4), 827-863

description: Excel file for reproduction of figures, based on described tracks of entry and coding of questions-per-track.
DOI: 10.7910/dvn/0fm0p4
title: A00_12904.JPG

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/c5c0c763-c569-3038-9e7e-bd3660a21fca'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/c5c0c763-c569-3038-9e7e-bd3660a21fca
DOI: 10.7910/dvn/0foap1
title: A13_25860.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/1ef51f93-c1f2-4e1e-be77-0c0b3c57389a'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/1ef51f93-c1f2-4e1e-be77-0c0b3c57389a
DOI: 10.7910/dvn/0fxkkx
title: Replication Data for: "Race, Paternalism, and Foreign Aid: Evidence from U.S. Public Opinion"

description: Two US nationwide surveys conducted over the internet with embedded experiments and about a dozen post-treatment measures of foreign aid attitudes, paternalism, and resentment. Datasets also contain demographic data. The CM experiment was carried out by Knowledge Networks and funded by TESS (N=2,031, white respondents only). The AG experiment was carried out by the Cooperative Congressional Elections Study (N=1,000). File also contains R code.
DOI: 10.7910/dvn/0g3qyq
title: hou02665c00991

description: Letter, Luis [Ramos?] of the Gobierno General de la Isla de Cuba to the bishop of Havana, Havana
description: URN-3:FHCL.HOUGH:100958561
DOI: 10.7910/dvn/0gncp5
title: Replication data for: Civil Wars Kill and Maim People—Long After the Shooting Stops

description: Political scientists have conducted only limited systematic research on the consequences of war for civilian populations. Here we argue that the civilian suffering caused by civil war extends well beyond the period of active warfare. We examine these longer-term effects in a cross-national (1999) analysis of World Health Organization new fine-grained data on death and disability broken down by age, gender, and type of disease or condition. We test hypotheses about the impact of civil wars and find substantial long-term effects, even after controlling for several other factors. We estimate that the additional burden of death and disability incurred in 1999, from the indirect and lingering effects of civil wars in the years 1991–97, was approximately equal to that incurred directly and immediately from all wars in 1999. This impact works its way through specific diseases and conditions and disproportionately affects women and children.
description: Subject: STANDARD DEPOSIT TERMS 1.0 Type: DATAPASS:TERMS:STANDARD:1.0 Notes: This study was deposited under the of the Data-PASS standard deposit terms. A copy of the usage agreement is included in the file section of this study.;
DOI: 10.7910/dvn/0gvyr
title: Senate Unpassed Legislation 1851, Docket 13162, SC1/series 231, Petition of Samuel Nutton

description: &lt;p&gt;Petition subject: Fugitive slave laws &lt;/p&gt; &lt;p&gt;Original: &lt;a href="http://nrs.harvard.edu/urn-3:FHCL:11858305"&gt;http://nrs.harvard.edu/urn-3:FHCL:11858305&lt;/a&gt; &lt;/p&gt; &lt;p&gt;Date of creation: (unknown) &lt;/p&gt; &lt;p&gt;Petition location: Lawrence &lt;/p&gt; &lt;p&gt;Selected signatures:&lt;ol&gt;&lt;li&gt;Samuel Nutton&lt;/li&gt;&lt;li&gt;Samuel E. Collins&lt;/li&gt;&lt;li&gt;Nathaniel Simonds&lt;/li&gt;&lt;/ol&gt; &lt;/p&gt; &lt;p&gt;Total signatures: 24 &lt;/p&gt; &lt;p&gt;Legal voter signatures (males not identified as non-legal): 12 &lt;/p&gt; &lt;p&gt;Female signatures: 5 &lt;/p&gt; &lt;p&gt;Other male signatures: 4 &lt;/p&gt; &lt;p&gt;Unidentified signatures: 3 &lt;/p&gt; &lt;p&gt;Female only signatures: No &lt;/p&gt; &lt;p&gt;Identifications of signatories: inhabitants, legal voters, other persons, [females], [other males] &lt;/p&gt; &lt;p&gt;Prayer format was &lt;a href="http://en.wikipedia.org/wiki/Printing"&gt;printed&lt;/a&gt; vs. &lt;a href="http://en.wikipedia.org/wiki/Manuscript"&gt;manuscript&lt;/a&gt;: Printed &lt;/p&gt; &lt;p&gt;Signatory column format: column separated &lt;/p&gt; &lt;p&gt;Additional non-petition or unrelated documents available at archive: no additional documents &lt;/p&gt; &lt;p&gt;Additional archivist notes: Not sure on lead petitioner &lt;/p&gt; &lt;p&gt;Location of the petition at the Massachusetts Archives of the Commonwealth: Senate Unpassed 1851, Docket 13162 &lt;/p&gt; &lt;p&gt;Acknowledgements: Supported by the National Endowment for the Humanities (PW-5105612), Massachusetts Archives of the Commonwealth, Radcliffe Institute for Advanced Study at Harvard University, Center for American Political Studies at Harvard University, Institutional Development Initiative at Harvard University, and Harvard University Library.&lt;/p&gt;
DOI: 10.7910/dvn/0hhml7
title: Replication data for: A Primary Cause of Partisanship? Nomination Systems and Legislator Ideology

description: Many theoretical and empirical accounts of representation argue that primary elections are a polarizing influence. Likewise, many reformers advocate opening party nominations to non-members as a way of increasing the number of moderate elected officials. Data and measurement constraints, however, have limited the range of empirical tests of this argument. We marry a unique new data set of state legislator ideal points to a detailed accounting of primary systems in the United States to gauge the effect of primary systems on polarization. We find that the openness of a primary election has little, if any, effect on the extremity of the politicians it produces.
description: Version Date: 2013-08-12Version Text: 1
DOI: 10.7910/dvn/0hsthd
title: Executive Agreements Database, Statement Regarding Agreement Between The United States and Pakistan Regarding the Consolidation and Rescheduling Of Certain Debts Owed To, Guaranteed By, Or Insured By The United States Government and Its Agencies Signed At Islamabad November 26, 1999

description: KAV 5690 cover memo
DOI: 10.7910/dvn/0i0skl
title: Wright Casebook Edited; Docketed Case: 19,509
DOI: 10.7910/dvn/0i3lbi
title: Militarism and Dual-Conflict Capacity

description: This research note examines how domestic institutions can moderate the relationship between domestic and interstate conflict involvement. Previous work has found that military dictatorships are more likely to become involved in either domestic or international conflicts, compared to party-based autocracies. We argue that the same institutional explanations for why military autocracies are more conflict-prone also make them less capable of successfully carrying out multiple conflicts at the same time. Analyzing interstate and domestic conflict involvement on a sample of dictatorships over the period 1947–2004, we show that military autocracies dealing with internal armed conflict are less likely than their nonmilitary counterparts to become involved in an international conflict.
DOI: 10.7910/dvn/0im1q6
title: A15_28454.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/97eaf22c-8bf3-4441-ab75-38cfcec4d2e5'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/97eaf22c-8bf3-4441-ab75-38cfcec4d2e5
DOI: 10.7910/dvn/0ioywc
title: A95_7434.jpg

description: Link to OCHRE database: &lt;a href = 'http://pi.lib.uchicago.edu/1001/org/ochre/a7b1d678-abb3-8cf2-8697-56d2f448f983'&gt;http://pi.lib.uchicago.edu/1001/org/ochre/a7b1d678-abb3-8cf2-8697-56d2f448f983
DOI: 10.7910/dvn/0ke1pn
title: Replication Data for: "Repression Works (just not in moderation)"

description: Why does government violence deter political challengers in one context, but inflame them in the next? This paper argues that repression increases opposition activity at low and moderate levels, but decreases it in the extreme. There is a threshold level of violence, where the opposition becomes unable to recruit new members, and the rebellion unravels --- even if the government kills more innocents. We find empirical support for this proposition in disaggregated data from Chechnya and a meta-analysis of sub-national conflict dynamics in 71 countries. The data suggest that a threshold exists, but the level of violence needed to reach it varies. Many governments, thankfully, are unable or unwilling to go that far. We explore conditions under which this threshold may be higher or lower, and highlight a fundamental trade-off between reducing government violence and preserving civil liberties.
DOI: 10.7910/dvn/0klatk
title: Radiation-Induced Lung Toxicity in Mice Irradiated in a Strong Magnetic Field - Mouse 122

description: Mouse 122: Irradiated 06/29/2016 Pre Scan: 06/28/2016 Post Scan: 11/16/2016