cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.14280711
title: Teaching methodologies in Human and Social Sciences in graduate studies programs in Public Health (2002-2016)

description: Abstract: The contributions by Human and Social Sciences in Health (HSSH) have been decisive for dealing with the social dynamics involving human life, suffering, and illness. Thus, analysis of the configuration of the HSSH field has been a key research theme for many Brazilian authors. This article analyzes training in HSSH (with a special focus on research training) in graduate studies programs in Public Health from 2002 to 2016, considering the course supply in HSSH and the courses involving methodological training, based on their size, frequency, and principal theoretical and methodological influences. Our source was the files of “Disciplines” and “Program Proposals” in the Indicator Notebooks from the Brazilian Graduate Studies Coordinating Board (CAPES) and Sucupira databases. The syllabuses were read and analyzed for their themes, objectives, bibliographies, and authors. Data were recorded on an Excel spreadsheet and analyzed with the R statistical package. The results show stability in the course supply in HSSH (some 20% over the period), but a modest presence of methodological courses in Social Sciences. We found a diversity of theoretical and methodological references, especially compilation works or didactic texts. We highlight the lack of classic texts and authors in the Social Sciences. The conclusions point to the challenge of transposing operative training, which allows instrumentally executing highly relevant research for health, but which can affect the potential for consolidation and theoretical innovation in social thinking in health.
DOI: 10.6084/m9.figshare.14280711.v1
title: Teaching methodologies in Human and Social Sciences in graduate studies programs in Public Health (2002-2016)

description: Abstract: The contributions by Human and Social Sciences in Health (HSSH) have been decisive for dealing with the social dynamics involving human life, suffering, and illness. Thus, analysis of the configuration of the HSSH field has been a key research theme for many Brazilian authors. This article analyzes training in HSSH (with a special focus on research training) in graduate studies programs in Public Health from 2002 to 2016, considering the course supply in HSSH and the courses involving methodological training, based on their size, frequency, and principal theoretical and methodological influences. Our source was the files of “Disciplines” and “Program Proposals” in the Indicator Notebooks from the Brazilian Graduate Studies Coordinating Board (CAPES) and Sucupira databases. The syllabuses were read and analyzed for their themes, objectives, bibliographies, and authors. Data were recorded on an Excel spreadsheet and analyzed with the R statistical package. The results show stability in the course supply in HSSH (some 20% over the period), but a modest presence of methodological courses in Social Sciences. We found a diversity of theoretical and methodological references, especially compilation works or didactic texts. We highlight the lack of classic texts and authors in the Social Sciences. The conclusions point to the challenge of transposing operative training, which allows instrumentally executing highly relevant research for health, but which can affect the potential for consolidation and theoretical innovation in social thinking in health.
DOI: 10.6084/m9.figshare.14280714
title: Forecasting the rate of cumulative cases of COVID-19 infection in Northeast Brazil: a Boltzmann function-based modeling study

description: Abstract: The COVID-19 death rate in Northeast Brazil is much higher when compared to the national average, demanding a study into the prognosis of the region for planning control measures and preventing the collapse of the health care system. We estimated the potential total cumulative cases of COVID-19 in the region for the next three months. Our study included all confirmed cases, from March 8 until April 28, 2020, collected from the official website that reports the situation of COVID-19 infections in Brazil. The Boltzmann function was applied to a data simulation for each set of data regarding different states. The model data were well fitted, with R2 values close to 0.999. Up to April 28, 20,665 cases were confirmed in the region. The state of Ceará has the highest rate of accumulated cases per 100,000 inhabitants (75.75), followed by Pernambuco. We estimated that the states of Ceará, Sergipe and Paraíba will experience a dramatic increase in the rate of cumulative cases until July 31. Maranhão, Pernambuco, Rio Grande do Norte and Piauí showed a more discreet increase in the model. For Bahia and Alagoas, a 4.7 and 6.6-fold increase in the rate was estimated, respectively. We estimate a substantial increase in the rate of cumulative cases per 100,000 inhabitants in the region within three months, especially for Ceará, Sergipe and Paraíba. The Boltzmann function proved to be a simple tool for epidemiological forecasting that can help planning the measures to contain COVID-19.
DOI: 10.6084/m9.figshare.14280708.v1
title: Implementation of the More Doctors Program in Espírito Santo State, Brazil: logic model and proposed indicators

description: The study aimed to assess the implementation of the More Doctors Program (PMM in Portuguese) based on a case study of the Espírito Santo State, Brazil. The first stage involved analyzing the documents that launched the PMM, allowing the creation of a logic model. In the second stage, data on the PMM in Espírito Santo State were analyzed (2013-2016) based on population brackets, creating indicators for the proportion of physicians before and after the Program with the following parameters: unacceptable (0 to 0.99 physicians/1,000 inhabitants); acceptable (1 to 1.99); and desirable (2.0 or more). Data were analyzed with the Wilcoxon and Kruskal-Wallis non-parametric tests. The model included the size, inputs, activities, outputs, results, and impact of the PMM, orienting analysis of the Program’s implementation. Of all the physicians in the emergency supply to Espírito Santo State (432), the majority (63.8%) were cooperative exchange physicians (Cubans), while 31.2% were regional board-accredited Brazilians. The Brazilian and individual exchange physicians were allocated mainly in medium and large municipalities, while the Cubans were distributed more heterogeneously in municipalities of all population sizes and were thus more common in areas with greater social vulnerability and lower social capital. There was a significant increase in the number of physicians in Espírito Santo State, but the supply to the extremely poor population did not reach the desired level, presenting an unacceptable mean rate in municipalities with up to 10,000 inhabitants and an acceptable rate in municipalities in the other population brackets.
DOI: 10.6084/m9.figshare.14280714.v1
title: Forecasting the rate of cumulative cases of COVID-19 infection in Northeast Brazil: a Boltzmann function-based modeling study

description: Abstract: The COVID-19 death rate in Northeast Brazil is much higher when compared to the national average, demanding a study into the prognosis of the region for planning control measures and preventing the collapse of the health care system. We estimated the potential total cumulative cases of COVID-19 in the region for the next three months. Our study included all confirmed cases, from March 8 until April 28, 2020, collected from the official website that reports the situation of COVID-19 infections in Brazil. The Boltzmann function was applied to a data simulation for each set of data regarding different states. The model data were well fitted, with R2 values close to 0.999. Up to April 28, 20,665 cases were confirmed in the region. The state of Ceará has the highest rate of accumulated cases per 100,000 inhabitants (75.75), followed by Pernambuco. We estimated that the states of Ceará, Sergipe and Paraíba will experience a dramatic increase in the rate of cumulative cases until July 31. Maranhão, Pernambuco, Rio Grande do Norte and Piauí showed a more discreet increase in the model. For Bahia and Alagoas, a 4.7 and 6.6-fold increase in the rate was estimated, respectively. We estimate a substantial increase in the rate of cumulative cases per 100,000 inhabitants in the region within three months, especially for Ceará, Sergipe and Paraíba. The Boltzmann function proved to be a simple tool for epidemiological forecasting that can help planning the measures to contain COVID-19.
DOI: 10.6084/m9.figshare.14280716
title: Emerging arboviruses (dengue, chikungunya, and Zika) in Southeastern Mexico: influence of socio-environmental determinants on knowledge and practices

description: Abstract: The proliferation of arboviruses and their vectors is influenced by a complex interplay between vector, environment and human behaviors. The aim of this work is to analyze the influence of socio-environmental determinants on knowledge and practices regarding arboviruses transmission, among the residents of three communities on the southern border of Mexico. Between June 2017 and August 2018, a set of 149 households from three communities of Tapachula (Chiapas) and Villahermosa (Tabasco) were covered. This study consists of the application of a community prevention project. Different surveys and methodological approaches were used. Associations between socio-environmental determinants and knowledge and practices for arboviruses transmission control were estimated by odds ratio. Logistic regression and qualitative techniques were used. Although around 75% of households had an adequate knowledge about arboviruses’ origin and transmission, only 30% of them adopted adequate practices. Domestic risk practices were associated with serious deficiencies in water and sanitation services. Furthermore, a perception of greater risk and difficulty in complying with preventive measures were detected. An adequate knowledge does not necessarily lead to adequate prevention practices. Intermediate social determinants influence on the persistence of risk behaviors for arboviruses proliferation. Addressing such related aspects requires the achievement of an effective and sustainable vector management.
DOI: 10.6084/m9.figshare.14280717
title: Visceral leishmaniasis control actions: epidemiological indicators for its effectiveness evaluation in a Brazilian urban area

description: Abstract: This research applies indicators concerning control of the visceral leishmaniasis canine reservoir in the city of Belo Horizonte, Minas Gerais State, Brazil. Data were obtained from the Zoonoses Control Information System (SCZOO) and the Brazilian Information System on Diseases of Notification (SINAN) database. First we analyzed (i) existing associations between canine epidemiological indicators, where the dependent variable was the canine seroprevalence A (2007 to 2013), and the independent variables were, as follows: canine seroprevalence B (2006 to 2012); percentage of positive dogs by ELISA test reagents that were not euthanized; the relationship between the human and canine population; canine population testing coverage by census surveys; and the years of study (2006 to 2013); (ii) then, we examined the association between human visceral leishmaniasis (HVL) cases between 2007 to 2013 and the mentioned variables related to dogs and years. Statistical analysis was done by a generalized linear model (GLM). One unit increases in canine seroprevalence B and canine seroprevalence A were associated to 13% and 12% increases in HVL rates, respectively. The increase in one human/dog ratio unit was associated with a 13% decrease in HVL rates. Canine seroprevalence, human/dog ratio and non-euthanasia of ELISA-reactive dogs in the environment were adequate indicators for analyzing the canine enzootic transmission and the occurrence of HVL cases.
DOI: 10.6084/m9.figshare.14280717.v1
title: Visceral leishmaniasis control actions: epidemiological indicators for its effectiveness evaluation in a Brazilian urban area

description: Abstract: This research applies indicators concerning control of the visceral leishmaniasis canine reservoir in the city of Belo Horizonte, Minas Gerais State, Brazil. Data were obtained from the Zoonoses Control Information System (SCZOO) and the Brazilian Information System on Diseases of Notification (SINAN) database. First we analyzed (i) existing associations between canine epidemiological indicators, where the dependent variable was the canine seroprevalence A (2007 to 2013), and the independent variables were, as follows: canine seroprevalence B (2006 to 2012); percentage of positive dogs by ELISA test reagents that were not euthanized; the relationship between the human and canine population; canine population testing coverage by census surveys; and the years of study (2006 to 2013); (ii) then, we examined the association between human visceral leishmaniasis (HVL) cases between 2007 to 2013 and the mentioned variables related to dogs and years. Statistical analysis was done by a generalized linear model (GLM). One unit increases in canine seroprevalence B and canine seroprevalence A were associated to 13% and 12% increases in HVL rates, respectively. The increase in one human/dog ratio unit was associated with a 13% decrease in HVL rates. Canine seroprevalence, human/dog ratio and non-euthanasia of ELISA-reactive dogs in the environment were adequate indicators for analyzing the canine enzootic transmission and the occurrence of HVL cases.
DOI: 10.6084/m9.figshare.14280720.v1
title: Vertical social distancing policy is ineffective to contain the COVID-19 pandemic

description: Abstract: Considering numerical simulations, this study shows that the so-called vertical social distancing health policy is ineffective to contain the COVID-19 pandemic. We present the SEIR-Net model, for a network of social group interactions, as a development of the classic mathematical model of SEIR epidemics (Susceptible-Exposed-Infected (symptomatic and asymptomatic)-Removed). In the SEIR-Net model, we can simulate social contacts between groups divided by age groups and analyze different strategies of social distancing. In the vertical distancing policy, only older people are distanced, whereas in the horizontal distancing policy all age groups adhere to social distancing. These two scenarios are compared to a control scenario in which no intervention is made to distance people. The vertical distancing scenario is almost as bad as the control, both in terms of people infected and in the acceleration of cases. On the other hand, horizontal distancing, if applied with the same intensity in all age groups, significantly reduces the total infected people “flattening the disease growth curve”. Our analysis considers the city of Belo Horizonte, Minas Gerais State, Brazil, but similar conclusions apply to other cities as well. Code implementation of the model in R-language is provided in the supplementary material.
DOI: 10.6084/m9.figshare.14280716.v1
title: Emerging arboviruses (dengue, chikungunya, and Zika) in Southeastern Mexico: influence of socio-environmental determinants on knowledge and practices

description: Abstract: The proliferation of arboviruses and their vectors is influenced by a complex interplay between vector, environment and human behaviors. The aim of this work is to analyze the influence of socio-environmental determinants on knowledge and practices regarding arboviruses transmission, among the residents of three communities on the southern border of Mexico. Between June 2017 and August 2018, a set of 149 households from three communities of Tapachula (Chiapas) and Villahermosa (Tabasco) were covered. This study consists of the application of a community prevention project. Different surveys and methodological approaches were used. Associations between socio-environmental determinants and knowledge and practices for arboviruses transmission control were estimated by odds ratio. Logistic regression and qualitative techniques were used. Although around 75% of households had an adequate knowledge about arboviruses’ origin and transmission, only 30% of them adopted adequate practices. Domestic risk practices were associated with serious deficiencies in water and sanitation services. Furthermore, a perception of greater risk and difficulty in complying with preventive measures were detected. An adequate knowledge does not necessarily lead to adequate prevention practices. Intermediate social determinants influence on the persistence of risk behaviors for arboviruses proliferation. Addressing such related aspects requires the achievement of an effective and sustainable vector management.
DOI: 10.6084/m9.figshare.14280720
title: Vertical social distancing policy is ineffective to contain the COVID-19 pandemic

description: Abstract: Considering numerical simulations, this study shows that the so-called vertical social distancing health policy is ineffective to contain the COVID-19 pandemic. We present the SEIR-Net model, for a network of social group interactions, as a development of the classic mathematical model of SEIR epidemics (Susceptible-Exposed-Infected (symptomatic and asymptomatic)-Removed). In the SEIR-Net model, we can simulate social contacts between groups divided by age groups and analyze different strategies of social distancing. In the vertical distancing policy, only older people are distanced, whereas in the horizontal distancing policy all age groups adhere to social distancing. These two scenarios are compared to a control scenario in which no intervention is made to distance people. The vertical distancing scenario is almost as bad as the control, both in terms of people infected and in the acceleration of cases. On the other hand, horizontal distancing, if applied with the same intensity in all age groups, significantly reduces the total infected people “flattening the disease growth curve”. Our analysis considers the city of Belo Horizonte, Minas Gerais State, Brazil, but similar conclusions apply to other cities as well. Code implementation of the model in R-language is provided in the supplementary material.
DOI: 10.6084/m9.figshare.14280723
title: Vulnerability to severe forms of COVID-19: an intra-municipal analysis in the city of Rio de Janeiro, Brazil

description: Given the characteristics of the COVID-19 pandemic and the limited tools for orienting interventions in surveillance, control, and clinical care, the current article aims to identify areas with greater vulnerability to severe cases of the disease in Rio de Janeiro, Brazil, a city characterized by huge social and spatial heterogeneity. In order to identify these areas, the authors prepared an index of vulnerability to severe cases of COVID-19 based on the construction, weighting, and integration of three levels of information: mean number of residents per household and density of persons 60 years or older (both per census tract) and neighborhood tuberculosis incidence rate in the year 2018. The data on residents per household and density of persons 60 years or older were obtained from the 2010 Population Census, and data on tuberculosis incidence were taken from the Brazilian Information System for Notificable Diseases (SINAN). Weighting of the indicators comprising the index used analytic hierarchy process (AHP), and the levels of information were integrated via weighted linear combination with map algebra. Spatialization of the index of vulnerability to severe COVID-19 in the city of Rio de Janeiro reveals the existence of more vulnerable areas in different parts of the city’s territory, reflecting its urban complexity. The areas with greatest vulnerability are located in the North and West Zones of the city and in poor neighborhoods nested within upper-income parts of the South and West Zones. Understanding these conditions of vulnerability can facilitate the development of strategies to monitor the evolution of COVID-19 and orient measures for prevention and health promotion.
DOI: 10.6084/m9.figshare.14280726
title: Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis

description: Abstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods (ICT). This is a systematic meta-analysis review of the diagnostic accuracy of IgA, NS1, IgM and/or IgG ICT studies in suspected cases of acute or convalescent dengue, using a combination of RT-PCR, ELISA NS1, IgM IgG or viral isolation as a reference standard. This protocol was registered in PROSPERO (CRD42014009885). Two pairs of reviewers searched the PubMed, BIREME, Science Direct, Scopus, Web of Science, Ovid MEDLINE JBrigs, SCIRUS and EMBASE databases, selected, extracted, and quality-assessed by QUADAS 2. Of 3,783 studies, we selected 57, of which 40 in meta-analyses according to the analyte tested, with high heterogeneity (I2 &gt; 90%), as expected for diagnostic tests. We detected higher pooled sensitivity in acute phase IgA (92.8%) with excellent (90%) specificity. ICT meta-analysis with NS1/IgM/IgG showed 91% sensitivity and 96% specificity. Poorer screening performance was for IgM/IgG ICT (sensitivity = 56%). Thus, the studies with NS1/IgM/IgG ICT showed the best combined performance in the acute phase of the disease.
DOI: 10.6084/m9.figshare.14280727
title: A morning with Louis Pasteur: a short history of the “clean hands”

description: Abstract: This article examines the story of Louis Pasteur from the point of view of a classic movie presented at the Weekly Seminars of the “Oswaldo Cruz Institute”, at the end of the 2017 activities. Although very old, the movie The Story of Louis Pasteur (Warner Bros., 1936) inspired spectators and gave rise to an energetic debate that led the authors to decide for publishing the comments of the Seminar Coordinator, the guest commentator and the audience. The movie communicates to the public the legacy of one of the greatest precursors of the public health history using also fictional characters. The article presents the reliable passages in Pasteur’s biography and the fictional ones, without disrespecting the production of the creators of cinematographic work. The major merit of the movie, one of the first steps towards the policy of scientific diffusion, is to disclose the importance of vaccines and hand hygiene to prevent infectious diseases. The authors argue that the film-maker impeccably captured the scientist’s tenacity in the relentless search for discoveries and Pasteur’s idea that only persistent work can lead to rewarding results, remembering that the context created by previous researchers enabled Pasteur to establish new paradigms. Finally, the authors cite movie passages illustrating realities that are still in force: (i) the inertial resistance of science to new paradigms, illustrated by the medical-scientific community opposing to simple practices proposition, such as washing hands and boiling instruments, and (ii) the excessive confidence, and even arrogance, of some specialists, instead of serenity and humility that arise from committed study and accumulated knowledge.