cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/drczc2m5mc.1
title: Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED. Smalakyte et al.

description: To combat phage infection, type III CRISPR-Cas systems utilize cyclic oligoadenylates (cAn) signaling to activate various auxiliary effectors, including the CRISPR-associated Lon-SAVED protease CalpL, which forms a tripartite effector system together with an anti-σ factor, CalpT, and an ECF-like σ factor, CalpS. Here we report the characterization of the Candidatus Cloacimonas acidaminovorans CalpL-CalpT-CalpS. We demonstrate that cA4 binding triggers CalpL filament formation and activates it to cleave CalpT within the CalpT-CalpS dimer. This cleavage exposes the CalpT C-degron, which targets it for further degradation by cellular proteases. Consequently, CalpS is released to bind to RNA polymerase, causing growth arrest in E. coli. Furthermore, the CalpL-CalpT-CalpS system is regulated by the SAVED domain of CalpL, which is a ring nuclease that cleaves cA4 in a sequential three-step mechanism. These findings provide key mechanistic details for the activation, proteolytic events, and regulation of the signaling cascade in the type III CRISPR-Cas immunity.

This dataset contains the original images of the gels, agar plates, and denoised cryo-EM micrographs from the paper "Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED" published in Molecular Cell.
DOI: 10.17632/pf6f3nnj9k.1
title: Hf-W isotope systematics of bulk chondrites and the chronology of core formation in iron meteorites

description: Hf-W data of bulk chondrites and terrestrial rock standards, core formation model ages of iron meteorites, Hf-W evolution line of R chondrites, Hf-W isochron data of Portales Valley and Shaw
DOI: 10.17632/xc26tczzbb.1
title: Open dataset results from IDEA4 method

description: From the National Research Institute for Agriculture, Food and Environment (INRAE) and the interprofessional association Bio Centre jointly initiated the SOBRIETY project, which aims (i) to assess the sustainability of farming systems in the Centre-Val de Loire region, France, and (ii) to point out the drivers that contribute to farm sustainability. To do so, 47 farms were surveyed with the released Farm Sustainability Indicators version 4 (IDEA4) method. IDEA4 assess both 3-dimensions (agroecological, socio-territorial and economic) and 5-attributes (embeddedness, self-sufficiency, productive and reproductive capacity of goods and services, Overall responsibility, and robustness) of sustainability at farm-scale. Each dimensions are based on components and associated indicators. Scoring process is based on hierarchical classification, aggregation score and threshold rules. The dataset provide three types of informations : 
- Biotechnical features : Those data were used to group farms into 3 farming systems based on a hierarchical clustering.
- 3 Dimensions, 13 components and 53 indicators results for the three farming systems identified through the clustering.
- 5 Attribute indicator scores per farming systems.
The last Excel sheet provides the R code used (version 4.1.3) for statistical analysis (2-Way ANOVA and PCAs).
DOI: 10.17632/vw85g2ndkk.1
title: LDHU3_14.1520

description: Kinesin K39; Leishmania donovani (HU3 strain)
DOI: 10.17632/4ywdfrgdfc.1
title: LDHU3_14.1500

description: Kinesin K39; Leishmania donovani (HU3 strain)
DOI: 10.17632/6397754ysn.1
title: LDHU3_14.1440

description: Protein kinase; Leishmania donovani (HU3 strain)
DOI: 10.17632/hdhddmntnf.1
title: Thermal Effectiveness in Liolaemus riojanus and L. scapularis

description: Field data on thermal biology of two endemic especies of sand-dwelling lizards from northwestern Argentina.
Temperatures were measured in degrees Celsius.
The body temperatures (Tb), the air one centimeter from the substrate (Ta) and the substrate surface (Ts) were recorded with the same instrument (Reed LM 8000) at the time of capturing each specimen in the field.
The operating temperatures (Te) were recorded with dataloggers (ibuttons) distributed in the different microenvironments used by the lizards.
The preferred temperatures (Tsel) result from the average of the individual records of 65 animals transferred to the laboratory and maintained in a thermal gradient (20 to 60 ºC) for 4 hours.
DOI: 10.17632/h2hf6xhpkx.1
title: Electrophysiological, perceptual, demographic, and audio data of soundscape listening in stereo and binaural formats

description: Objective
This work aims to understand the listening perception of subjects to soundscapes in binaural and stereo audio formats employing subjective and electroencephalographic responses

Design
The experimental procedure consisted of EEG recordings of eyes-closed resting state for 60 seconds. After that, a randomly selected soundscape was played for two minutes using AKG K240 headphone model. Finally, the participant was instructed to answer the Slater-Usoh-Steed (SUS) questionnaire for around 15 seconds. This cycle was repeated eight times with different soundscapes without repetition, and participants kept their eyes closed during soundscape playback. The sequence of the soundscapes was randomized for every participant.

Content
Audio tracks folder: Eight wave files in 48k Hz sample rate and 24-bit depth of four soundscapes: 1) Natural: La Estanzuela Ecological Park, 2)Parque: Santa Lucía Riverwalk, 3) Trafico: Eugenio Garza Sada avenue in the city of Monterrey, and 4) Music: Society music soundscape of Metapatio music venue. All soundscapes were recorded at the original locations in the state of Nuevo Leon, Mexico. Each soundscape was recorded in stereo (St) and binaural (Bin) formats, resulting in two audio files per soundscape.

EEG folder: EEG data in GDF format of 30 individuals answering the SUS presence questionnaire of subjects while listening four soundscapes in two audio formats. Data was recorded at 250 Hz using the Unicorn Hybrid Black EEG system and OpenVibe for data acquisition. Only subject 33 has two GDF files, one for resting state and one for the listening condition.

Events order folder: json files generated with the L2_experiment_playback max patch indicating the presentation order of the eight audio tracks in the EEG files.

DataSpecs excel file: Five worksheets containing the following information:
1. Demographic data: This file contains the demographic information (age, sex, nationality, dexterity, academic level, and music or audio expertise) of subjects.
2. SUS answer: Answers of subjects to the three items of the SUS questionnaire per audio file. The score of answers corresponds to a 7-point Likert scale from 1 to 7. Missing answers are indicated with dashes (-).
3. Presentation_original: presentation order of soundscapes as indicated in original json and audio files. Soundscapes were presented to subjects in random order.
4. Presentation_english: This sheet has the same information as Presentation_original but is standardized to English.
5. EEG stimulation codes: Information of stimulation in EEG files to indicate soundscape playback and subject responses. Each stimulation code is associated with an event (e.g., audio playback, the question presented to the subject, and the subject response). A description of each event is given as well.

L2_experimet_playback: Max patch used for randomization of presentation order and playback of soundscapes.
DOI: 10.17632/ygcnm5rhst.2
title: Homogenization results for the X-shaped microstructure

description: This dataset contains homogenization results for an X-shaped periodic microstructure - see figure "Xcell.pdf". Elastic components of the cell and the plane strain conditions have been considered. Homogenization computations were performed using the finite element method and the 6-node triangular elements with an average size equal to 0.025a.

Both data files contain the following columns:

d1/a
d2/a
d3/a
d4/a
λf/λs
C1111/λs
C1112/λs
C1122/λs
C1212/λs
C1222/λs
C2222/λs

The first 5 columns describe the geometry and stiffness ratio of the components of the microstructural cell (λ is for Lame constant). Please refer to the "Xcell.pdf" figure for the notation details. The remaining 6 columns are for the effective stiffness tensor components related to the λs (1 is for horizontal and 2 for vertical direction).

'Xcell_1000_samples.txt' contains results for 1000 setups of the cell. These setups were sampled randomly from 5D parameter space using the LHS sampling method.
'Xcell_2000_samples.txt' contains additionally 1000 permutations of the first 1000 results. These permutations reflect the effective stiffness of the cells rotated by 90 degrees. For example, data row 1001 is a permutation of data row 1, reflecting its 90-degree rotation.
DOI: 10.17632/zy973m27bx.1
title: LINF_110015900

description: Adaptin N domain-containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/y88ksnm8xx.1
title: Mode-II delamination properties of thick glass-fiber/epoxy composite laminates using end-loaded split experiments

description: The data shows the experimental results for Mode-II fracture properties of glass-fiber/epoxy composite laminates, which consist of 14 layers of continuous filament mats and 6 layers of quadriaxial sewed fabrics. The experiments were conducted using an end-loaded split testing apparatus according to the standard ISO 15114:2014, and the results were processed using the experimental compliance method with correction factors considered. Note the crack length measurements include microcracking-zone length. Due to the transverse shear effects from the large thickness and the asymmetric fiber layup of the sub-laminates, the R-curves derived contain certain errors.
DOI: 10.17632/cxtcdxxf3f.1
title: LINF_120006400

description: protein kinase; Leishmania infantum (strain JPCM5)
DOI: 10.17632/x7857bkkhg.1
title: LINF_110018600

description: tatD related deoxyribonuclease; Leishmania infantum (strain JPCM5)
DOI: 10.17632/9dkwhd85dx.1
title: Edge effects of linear disturbances on plant functional traits in boreal fens of northern Alberta, Canada

description: This data was collected to generate findings on edge effects of linear disturbances in boreal peatlands, through collection of plant tissues for lab analysis and direct plant metric measurements in the field.
DOI: 10.17632/dt78jhyw2j.1
title: VIS-Spectrometric data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)

description: Please, see follow dataset:
1. Morphometric data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)
2. Biometric data (include DQI) of some individual seedlings produced from seeds of the Negorelskaya variety Pinus sylvestris L. (empirical refilled dataset)
3. Germination data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)
DOI: 10.17632/dt78jhyw2j.3
title: VIS-Spectrometric data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)

description: Please, see follow dataset:
1. Morphometric data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)
2. Biometric data (include DQI) of some individual seedlings produced from seeds of the Negorelskaya variety Pinus sylvestris L. (empirical refilled dataset)
3. Germination data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)
DOI: 10.17632/dt78jhyw2j.2
title: VIS-Spectrometric data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)

description: Please, see follow dataset:
1. Morphometric data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)
2. Biometric data (include DQI) of some individual seedlings produced from seeds of the Negorelskaya variety Pinus sylvestris L. (empirical refilled dataset)
3. Germination data of individual seeds (N = 1200) of the Negorelskaya variety Pinus sylvestris L. (empirical dataset)
DOI: 10.17632/r57drh58pm.4
title: Gypsum from soils of chesas, NE Spain

description: We show data of soils developed on the outcropping gypseous nucleus of the Barbastro-Balaguer anticline, NE Spain. Chesas is the local name for the lands of this outcrop that stands out in the landscape by its whitish tones. The data collected here come from soils of the municipalities —from West to East— of Peraltilla, Almunia de San Juan, San Esteban, Tamarite, Alcampell, Ivars de Noguera, Camarasa, Torá, and Iborra. The analytical methods plus details of the landscape and sampling sites can be found in: (i) the book entitled “Morfología y génesis de suelos sobre yesos” (http://hdl.handle.net/10261/84695), and (ii) the article entitled “Salada Farrachuela, a saline wetland in Tamarite de Litera, Spain” (DOI: 10.29077/bol.114.ce05.herrero).
Here we present a compressed zip file with 300 TIFF images corresponding to 150 thin sections of these soils scanned under both plane polarized and crossed polarizers light. Some of the sections, marked L, are of lichens and their gypseous substrate. Most of the sections —with the prevalent size of 13.5 × 5.7 cm— were manufactured by the first author in the Institut National Agronomique de Paris-Grignon under the technical supervision of Mr. Pierre Guilloré, in the context of a scholarship granted by the Government of France for working in the lab of Dr. Nicolas Fédoroff. The surviving thin sections are archived at the EEAD-CSIC in Zaragoza, Spain. Their scans are compiled in the file “Chesas_150thinsections.zip”.
Several dozen micrographs of the chesas thin sections appeared in the above mentioned book published in 1991 (http://hdl.handle.net/10261/84695). The file “Chesas_Fig.captions1991-01.xlsx” presents a tentative English translation of the 154 Figure captions for the micrographs and the other figures in the book.
The analytical results for the samples having gypsum determinations are listed in the files “ChesasGyps_Peraltilla-Tora-Iborra.xlsx” and “ChesasGyps_Tamarite.xlsx”

Documents:
Chesas_150thin_sections.zip
Chesas_Fig.captions1991-01.xlsx
ChesasGyps_Peraltilla-Tora-Iborra.xlsx
ChesasGyps_Tamarite.xlsx

Funding
We acknowledge the grant PID2021-127170OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, and the grant TED2021-130303B-I00 funded by MCIN/AEI/10.13039/501100011033 and by the “European Union NextGeneration EU/PRTR”.
DOI: 10.17632/9fnddtjppj.1
title: Treatment with Wedelolactone reverses AKI caused by Bothrops jararacussu envenomation.

description: Summary: Snakebite-induced acute kidney injury (sAKI) is a severe clinical complication associated with Bothrops envenomation, often leading to renal failure and chronic kidney disease (CKD). This study evaluates the nephroprotective effects of wedelolactone (WEL), a bioactive coumestan derived from Eclipta prostata (EP), in a preclinical model of sAKI. Wistar rats were intramuscularly administered 3.5 mg/kg Bothrops jararacussu (Bj) venom to induce sAKI, followed by treatment with WEL (2, 5, or 10 mg/kg) two hours post-envenomation. At 5 mg/Kg, WEL effectively mitigated renal dysfunction, preserving glomerular filtration rate (GFR), and reducing proteinuria. Histological analysis revealed preserved kidney cytoarchitecture and reduced collagen deposition. Biochemical studies showed that WEL decreased matrix metalloproteinase (MMP) activity and nitrite levels, key contributors to Bj-induced nephrotoxicity, while antioxidant mechanisms were implicated in its protective effects. WEL 2 or 5 mg/Kg did not block Bj-induced muscle damage demonstrating that its molecular mechanism involves the direct impact of the venom in the kidney. Importantly, WEL did not affect kidney function in normal rats. These findings highlight the translational potential of WEL as a complementary therapeutic agent for managing sAKI and reducing the long-term burden of snakebite-related kidney disease.
Experimental protocol: According to Romanelli et al., 2021
Two hours after envenomation, both Ctrl and Bj groups were further subdivided into WEL-treated subgroups, receiving one of the three different WEL doses (IM; 2, 5 or 10 mg/Kg) in the posterior region of the left thigh. This created the following final groups: Ctrl, Ctrl+W2, Ctrl+W5, Ctrl+W10, Bj, Bj+W2, Bj+W5, and Bj+W10. 

Graphics and Tables:
Fig 1 Measure of muscle injury: using a caliper to quantify the extent of the injury. 
Table 2 andTtable 3. Renal function analysis according to Romanelli et al., 2021.
Fig 2: Na+ transporters activity, measured accordin to Pereira-Acácio et al., 2022
Fig 5, 6 and 7. Kidney histomorphometric parameters
Fig 6. Matrix metalloproteinase activity according to Soeiro et al., 2021 
Fig 9. ER Stresse markers by western blot analysis
Fig 10. Oxidative stress, according to Bryan et al., 2007 and Figueiredo-Junior et al., 2022.

Histological Images - Fig 5, 6 and 7

Western blot - Fig 2A and 9

Multiple group comparisons were performed using one-way analysis of variance (ANOVA) followed by Sidak's post hoc test. Statistical analysis were conducted to compare WEL treatment effects in healthy rats (Ctrl vs Ctrl+W2, Ctrl+W5 or Ctrl+W10 groups), the impact of Bj venom exposure (Ctrl vs Bj groups) and the effects of WEL treatment following Bj envenomation (Bj vs Bj+W2, Bj+W5 or Bj+W10 groups). A p value &lt; 0.05 was considered statistically significant. Statistical tests and graphs generation were performed using GraphPad Prism 8.0.2 software (GraphPad Inc., La Jolla, CA).
DOI: 10.17632/tr4ptdg8gx.2
title: Morphometric, structural and kinematic data of the Isverna karst system, SW Southern Carpathians (Romania)

description: The study of caves and karst is important because it may provide detailed information on the geologic structure and tectonic evolution of orogenic systems. The highly arcuate belt of the Southern Carpathians resulted from multi-stage tectonic evolution, including thrusting, nappe stacking, extension, and strike-slip deformation. Isverna karst system developed between two minor subparallel dextral strike-slip faults (Brebina and Isverna-Ponoarele), adjacent to the Cerna-Jiu master fault. The study of the most important two caves in this system, Isverna and Ascunsă, allowed the reconstruction of a more refined evolutionary framework of this shear zone using 3D models.
The dataset contains microtectonic measurements of fractures, cave passage orientations, Riedel shears geometry, and kinematic data (faults, stretching lineation and S-C foliation of tectonic mélange, and calcite slickenfibers) analyzed in the article From nappe stacking to strike-slip deformation: Alpine structural overprints refined by cave and karst geology in the Danubian thin-skinned units (Southern Carpathians, Romania) by Tîrlă et al. (2024), published in the Tectonophysics journal. The link to the online version of the published article is provided below.
Structural and kinematic data collected from field measurements were processed in Stereonet and TectonicsFP software packages. The doline morphometry data was generated in ArcGIS Pro software, and mainly shows the area and the long axis of dolines, which can be correlated to faults and fractures.
DOI: 10.17632/zjbcgr927x.1
title: Characterization and treatment outcomes of biologic therapy in super-responders and biologic-refractory psoriasis patients: A single-center retrospective study in China

description: Supplementary Figure 1 illustrates the inclusion and exclusion criteria for psoriasis patients in this study. The univariable logistic regression analyses of patient characteristics associated with super-responders, as compared to non-super-responders, are presented in Supplementary Table 1. The results of univariable logistic regression analyses of patient characteristics associated with biologic-refractory patients, in comparison to non-biologic-refractory patients, are provided in Supplementary Table 2.
DOI: 10.17632/3m9rxfznpm.1
title: LDHU3_20.1850

description: SET domain-containing protein; Leishmania donovani (HU3 strain)
DOI: 10.17632/w92bbxbcgd.1
title: Low-temperature Thermochronology data from Patagonia

description: This is an apatite and zircon (U-Th)/He dataset from the Fitz Roy and Torres del Paine regions in Southern Patagonia. The AHe data were analysed in the University of Arizona and University of Berkeley, USA and the ZHe data were analysed in the GEOPS Laboratory in the Paris-Saclay University, France. This data support the study “Geodynamic and climatic forcing on late-Cenozoic exhumation of the Southern Patagonian Andes (Fitz Roy and Torres del Paine massifs)” by Muller, V.A.P. et al., 2023 (DOI: 10.22541/essoar.168332179.93378898/v1).
DOI: 10.17632/w92bbxbcgd.2
title: Low-temperature Thermochronology data from Patagonia

description: This is the apatite and zircon (U-Th)/He dataset from the Fitz Roy and Torres del Paine massifs in Southern Patagonia that supports the study in revision: “Geodynamic and climatic forcing on late-Cenozoic exhumation of the Southern Patagonian Andes (Fitz Roy and Torres del Paine massifs)” by Muller, V.A.P. et al., 2023 (preprint DOI: 10.22541/essoar.168332179.93378898/v1).

Apatite (U-Th/He) thermochronometry was performed following standard procedures (House et al., 2000) at the ARHDL of University of Arizona (USA) for plutonic samples of Torres del Paine, and at the Berkeley Geochronology Center (USA) for metasedimentary samples of Torres del Paine. Apatite (U-Th/He) thermochronometry of Fitz Roy plutonic samples was performed in the GEOPS Laboratory at the Paris-Saclay University (Orsay, France), following the methods of Gautheron et al., (2021). Zircon (U-Th/He) thermochronometry of Fitz Roy plutonic samples was performed in the UTHHE Laboratory of Dalhousie University (Halifax, Canada) following the methods of Reiners et al. (2004, 2005).
DOI: 10.17632/bdsxsw5dv3.1
title: LDHU3_20.1960

description: Cell division cycle protein-like protein; Leishmania donovani (HU3 strain)
DOI: 10.17632/4zm398yrd5.1
title: LDHU3_20.1910

description: Zinc-binding phosphatase; Leishmania donovani (HU3 strain)
DOI: 10.17632/svtmy3274p.2
title: Do interventions for mood improve inflammatory biomarkers in Inflammatory Bowel Disease?: A Systematic Review and Meta-Analysis

description: Meta-analysis of RCTs in adults with IBD that trialled interventions that included mood (depression, anxiety, stress, distress, or poor emotional well-being) as a primary or secondary outcome. All studies had to include an inflammatory biomarker, measured pre- and post-intervention. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. Five electronic databases (in MEDLINE, EMBASE, PsycINFO, Global Health (through Ovid, 2022) and Web of Science (through Clarivate 2022), from 1947 to October 2023) were searched. Independent reviewers screened studies, extracted data, and assessed methodological quality. Data were pooled to estimate standardised mean differences (SMD) with 95% Confidence Intervals (CIs). A random-effects robust variance estimation accounted for studies measuring multiple biomarkers. Intervention type, mood as a primary or secondary outcome, effect on mood outcomes and IBD subtype were investigated as treatment effect moderators. Where there were sufficient biomarkers, individual meta-analyses were run (Pre-registration PROSPERO: CRD42023389401).

28 RCTs involving 1789 participants met inclusion criteria. Interventions demonstrated small, statistically significant effects on biomarkers (-0.35, 95%CI:-0.48, -0.22, p&lt;0.001) and medium effects on mood outcomes (-0.50, 95%CI:-0.73, -0.27, p&lt;0.001), without evidence of substantive heterogeneity or publication bias. Individual analyses showed small effects for improved faecal calprotectin (-0.19, 95%CI:-0.34, -0.03, p=0.018) and C-Reactive Protein (-0.29, 95%CI: -0.47, -0.10, p=0.002). Effect sizes were larger for psychological therapy interventions (compared with exercise or antidepressants) and when there was an effect (SMD≥0.2) on mood.