cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13130/rd_unimi/f0jgu8/lljwl7
title: Luglio_1928_Pagina_010.jpg

description: Bulletin of 1928/07/03
DOI: 10.13130/rd_unimi/f0jgu8/b02gp8
title: Luglio_1928_Pagina_011.jpg

description: Bulletin of 1928/07/03
DOI: 10.13130/rd_unimi/f0jgu8/cv7frt
title: Luglio_1928_Pagina_012.jpg

description: Bulletin of 1928/07/03
DOI: 10.13130/rd_unimi/f0jgu8/135dgs
title: Luglio_1928_Pagina_013.jpg

description: Bulletin of 1928/07/04
DOI: 10.13130/rd_unimi/f0jgu8/tkgfgq
title: Luglio_1928_Pagina_014.jpg

description: Bulletin of 1928/07/04
DOI: 10.13130/rd_unimi/f0jgu8/api3ga
title: Luglio_1928_Pagina_015.jpg

description: Bulletin of 1928/07/04
DOI: 10.13130/rd_unimi/f0jgu8/nkjyqj
title: Luglio_1928_Pagina_016.jpg

description: Bulletin of 1928/07/04
DOI: 10.13130/rd_unimi/f0jgu8/c8hbnt
title: Luglio_1928_Pagina_017.jpg

description: Bulletin of 1928/07/05
DOI: 10.13130/rd_unimi/f0jgu8/1rtxba
title: Luglio_1928_Pagina_018.jpg

description: Bulletin of 1928/07/05
DOI: 10.13130/rd_unimi/f0jgu8/ehx46k
title: Luglio_1928_Pagina_019.jpg

description: Bulletin of 1928/07/05
DOI: 10.13130/rd_unimi/f0jgu8/zgt7ht
title: Luglio_1928_Pagina_020.jpg

description: Bulletin of 1928/07/05
DOI: 10.5281/zenodo.17937661
title: Georgia: Survey on the  war in Ukraine 2022

description: The main objective of this research was to study the attitudes of Georgian population towards war in Ukraine. The survey examined who Georgians blame for the war, what they want the government to do, and the domestic political fallout of the government's response.

Population: Adult population (18 years old and over), excluding the populations living in territories affected by military conflict (South Ossetia and Abkhazia). Besides nationwide, data is representative of Tbilisi, urban and rural areas of Georgia.

Sample Design: Simple random sampling using random-digit-dial method.

Sample Size: 1,092 respondents.

Response rate: 24%

Survey mode: Computer-assisted telephone interview (CATI).

Interview languages: Georgian, Armenian, Azerbaijani and Russian.

Fieldwork Dates: March 7, 2022 to March 10, 2022.

Results are weighted.
description: Published on Discuss Data, https://discuss-data.net/dataset/df022aa2-cfea-4538-9176-569299d9682f/
description: Method(s) of data collection: Cati (Computer-Assisted Telephone Interviews), Quantitative Survey
DOI: 10.5281/zenodo.17937662
title: Georgia: Survey on the  war in Ukraine 2022

description: The main objective of this research was to study the attitudes of Georgian population towards war in Ukraine. The survey examined who Georgians blame for the war, what they want the government to do, and the domestic political fallout of the government's response.

Population: Adult population (18 years old and over), excluding the populations living in territories affected by military conflict (South Ossetia and Abkhazia). Besides nationwide, data is representative of Tbilisi, urban and rural areas of Georgia.

Sample Design: Simple random sampling using random-digit-dial method.

Sample Size: 1,092 respondents.

Response rate: 24%

Survey mode: Computer-assisted telephone interview (CATI).

Interview languages: Georgian, Armenian, Azerbaijani and Russian.

Fieldwork Dates: March 7, 2022 to March 10, 2022.

Results are weighted.
description: Published on Discuss Data, https://discuss-data.net/dataset/df022aa2-cfea-4538-9176-569299d9682f/
description: Method(s) of data collection: Cati (Computer-Assisted Telephone Interviews), Quantitative Survey
DOI: 10.13130/rd_unimi/f0jgu8/pwlltv
title: Luglio_1928_Pagina_021.jpg

description: Bulletin of 1928/07/06
DOI: 10.13130/rd_unimi/f0jgu8/iirbvp
title: Luglio_1928_Pagina_022.jpg

description: Bulletin of 1928/07/06
DOI: 10.13130/rd_unimi/f0jgu8/eukc3k
title: Luglio_1928_Pagina_024.jpg

description: Bulletin of 1928/07/06
DOI: 10.13130/rd_unimi/f0jgu8/otaz4j
title: Luglio_1928_Pagina_023.jpg

description: Bulletin of 1928/07/06
DOI: 10.13130/rd_unimi/f0jgu8/5tebde
title: Luglio_1928_Pagina_025.jpg

description: Bulletin of 1928/07/07
DOI: 10.13130/rd_unimi/f0jgu8/nm8kbe
title: Luglio_1928_Pagina_026.jpg

description: Bulletin of 1928/07/07
DOI: 10.13130/rd_unimi/f0jgu8/gte5gt
title: Luglio_1928_Pagina_028.jpg

description: Bulletin of 1928/07/07
DOI: 10.13130/rd_unimi/f0jgu8/pwygnn
title: Luglio_1928_Pagina_027.jpg

description: Bulletin of 1928/07/07
DOI: 10.13130/rd_unimi/f0jgu8/gbzsuo
title: Luglio_1928_Pagina_029.jpg

description: Bulletin of 1928/07/08
DOI: 10.13130/rd_unimi/f0jgu8/221kwp
title: Luglio_1928_Pagina_030.jpg

description: Bulletin of 1928/07/08
DOI: 10.13130/rd_unimi/f0jgu8/fz0son
title: Luglio_1928_Pagina_031.jpg

description: Bulletin of 1928/07/08
DOI: 10.13130/rd_unimi/f0jgu8/ad6if3
title: Luglio_1928_Pagina_032.jpg

description: Bulletin of 1928/07/08
DOI: 10.13130/rd_unimi/f0jgu8/gb08yg
title: Luglio_1928_Pagina_033.jpg

description: Bulletin of 1928/07/09
DOI: 10.13130/rd_unimi/f0jgu8/k4qvpc
title: Luglio_1928_Pagina_034.jpg

description: Bulletin of 1928/07/09
DOI: 10.13130/rd_unimi/f0jgu8/8qlqdi
title: Luglio_1928_Pagina_035.jpg

description: Bulletin of 1928/07/09
DOI: 10.13130/rd_unimi/f0jgu8/okjqmn
title: Luglio_1928_Pagina_036.jpg

description: Bulletin of 1928/07/09
DOI: 10.13130/rd_unimi/f0jgu8/ydssin
title: Luglio_1928_Pagina_037.jpg

description: Bulletin of 1928/07/10
DOI: 10.13130/rd_unimi/f0jgu8/10dm7n
title: Luglio_1928_Pagina_038.jpg

description: Bulletin of 1928/07/10
DOI: 10.13130/rd_unimi/f0jgu8/8s9uo8
title: Luglio_1928_Pagina_040.jpg

description: Bulletin of 1928/07/10
DOI: 10.13130/rd_unimi/f0jgu8/djwo66
title: Luglio_1928_Pagina_039.jpg

description: Bulletin of 1928/07/10
DOI: 10.13130/rd_unimi/f0jgu8/kkbeow
title: Luglio_1928_Pagina_041.jpg

description: Bulletin of 1928/07/11
DOI: 10.13130/rd_unimi/f0jgu8/9hrk7m
title: Luglio_1928_Pagina_042.jpg

description: Bulletin of 1928/07/11
DOI: 10.13130/rd_unimi/f0jgu8/0sk6zr
title: Luglio_1928_Pagina_043.jpg

description: Bulletin of 1928/07/11
DOI: 10.13130/rd_unimi/f0jgu8/ndbmxo
title: Luglio_1928_Pagina_044.jpg

description: Bulletin of 1928/07/11
DOI: 10.13130/rd_unimi/f0jgu8/pgfwpf
title: Luglio_1928_Pagina_045.jpg

description: Bulletin of 1928/07/12
DOI: 10.13130/rd_unimi/f0jgu8/f1n4kf
title: Luglio_1928_Pagina_046.jpg

description: Bulletin of 1928/07/12
DOI: 10.13130/rd_unimi/f0jgu8/dn1ccm
title: Luglio_1928_Pagina_047.jpg

description: Bulletin of 1928/07/12
DOI: 10.13130/rd_unimi/f0jgu8/lhzf9q
title: Luglio_1928_Pagina_048.jpg

description: Bulletin of 1928/07/12
DOI: 10.13130/rd_unimi/f0jgu8/mpfoht
title: Luglio_1928_Pagina_049.jpg

description: Bulletin of 1928/07/13
DOI: 10.13130/rd_unimi/f0jgu8/ed9fgy
title: Luglio_1928_Pagina_050.jpg

description: Bulletin of 1928/07/13
DOI: 10.13130/rd_unimi/f0jgu8/pmlozb
title: Luglio_1928_Pagina_051.jpg

description: Bulletin of 1928/07/13
DOI: 10.13130/rd_unimi/f0jgu8/qv78s6
title: Luglio_1928_Pagina_052.jpg

description: Bulletin of 1928/07/13
DOI: 10.13130/rd_unimi/f0jgu8/ozhefm
title: Luglio_1928_Pagina_053.jpg

description: Bulletin of 1928/07/14
DOI: 10.13130/rd_unimi/f0jgu8/s4gje4
title: Luglio_1928_Pagina_054.jpg

description: Bulletin of 1928/07/14
DOI: 10.13130/rd_unimi/f0jgu8/qkxorv
title: Luglio_1928_Pagina_055.jpg

description: Bulletin of 1928/07/14
DOI: 10.13130/rd_unimi/f0jgu8/r1r7fa
title: Luglio_1928_Pagina_056.jpg

description: Bulletin of 1928/07/14
DOI: 10.13130/rd_unimi/f0jgu8/gtsqst
title: Luglio_1928_Pagina_058.jpg

description: Bulletin of 1928/07/15
DOI: 10.13130/rd_unimi/f0jgu8/hxtbzt
title: Luglio_1928_Pagina_057.jpg

description: Bulletin of 1928/07/15
DOI: 10.13130/rd_unimi/f0jgu8/ms4fzj
title: Luglio_1928_Pagina_059.jpg

description: Bulletin of 1928/07/15
DOI: 10.13130/rd_unimi/f0jgu8/wd1ixo
title: Luglio_1928_Pagina_060.jpg

description: Bulletin of 1928/07/15
DOI: 10.13130/rd_unimi/f0jgu8/qabpje
title: Luglio_1928_Pagina_061.jpg

description: Bulletin of 1928/07/16
DOI: 10.13130/rd_unimi/f0jgu8/yowtbk
title: Luglio_1928_Pagina_062.jpg

description: Bulletin of 1928/07/16
DOI: 10.13130/rd_unimi/f0jgu8/70efmq
title: Luglio_1928_Pagina_064.jpg

description: Bulletin of 1928/07/16
DOI: 10.13130/rd_unimi/f0jgu8/podgja
title: Luglio_1928_Pagina_063.jpg

description: Bulletin of 1928/07/16
DOI: 10.13130/rd_unimi/f0jgu8/6ahrtv
title: Luglio_1928_Pagina_065.jpg

description: Bulletin of 1928/07/17
DOI: 10.13130/rd_unimi/f0jgu8/viowap
title: Luglio_1928_Pagina_066.jpg

description: Bulletin of 1928/07/17
DOI: 10.13130/rd_unimi/f0jgu8/tiqf3s
title: Luglio_1928_Pagina_068.jpg

description: Bulletin of 1928/07/17
DOI: 10.13130/rd_unimi/f0jgu8/vpjjrf
title: Luglio_1928_Pagina_067.jpg

description: Bulletin of 1928/07/17
DOI: 10.13130/rd_unimi/f0jgu8/j8wnux
title: Luglio_1928_Pagina_069.jpg

description: Bulletin of 1928/07/18
DOI: 10.13130/rd_unimi/f0jgu8/oxpl5r
title: Luglio_1928_Pagina_070.jpg

description: Bulletin of 1928/07/18
DOI: 10.13130/rd_unimi/f0jgu8/efkdya
title: Luglio_1928_Pagina_072.jpg

description: Bulletin of 1928/07/18
DOI: 10.13130/rd_unimi/f0jgu8/qv4igg
title: Luglio_1928_Pagina_071.jpg

description: Bulletin of 1928/07/18
DOI: 10.13130/rd_unimi/f0jgu8/chqkhj
title: Luglio_1928_Pagina_073.jpg

description: Bulletin of 1928/07/19
DOI: 10.13130/rd_unimi/f0jgu8/oe9ovq
title: Luglio_1928_Pagina_074.jpg

description: Bulletin of 1928/07/19
DOI: 10.13130/rd_unimi/f0jgu8/7utebd
title: Luglio_1928_Pagina_076.jpg

description: Bulletin of 1928/07/19
DOI: 10.13130/rd_unimi/f0jgu8/i4nmip
title: Luglio_1928_Pagina_075.jpg

description: Bulletin of 1928/07/19
DOI: 10.5281/zenodo.15488631
title: Dataset: Exploring Architectural Smells Detection Through LLMs

description: Architectural Smells (AS) are design patterns in software systems that violate design principles, potentially compromising maintainability and overall quality. As software complexity grows, suboptimal architectural decisions can lead to technical debt, making system evolution more difficult and costly over time.

Early detection of AS is crucial to prevent this accumulation. Among the various types of AS, this study focuses on the Hub-Like Dependency (HL) smell, which occurs when an abstraction has many incoming and outgoing dependencies, forming a hub-like structure in the dependency graph.

Traditional detection methods rely on rule-based systems, which often miss architectural issues requiring a deeper understanding of design context. Large Language Models (LLMs) offer a promising alternative, as they can analyze large amounts of code and have shown potential in detecting code smells, vulnerabilities, and suggesting refactorings. However, no prior study has specifically investigated the use of LLMs for AS detection.

This research explores the detection of HL smells using Google’s Gemini 1.5 Pro and compares its performance with Arcan, a specialized AS detection tool. Additionally, the study evaluates whether LLMs can provide explanations and refactoring suggestions for the detected smells.
DOI: 10.13130/rd_unimi/f0jgu8/kr4ser
title: Luglio_1928_Pagina_077.jpg

description: Bulletin of 1928/07/20
DOI: 10.5281/zenodo.14961252
title: Dataset: Exploring Architectural Smells Detection Through LLMs

description: Architectural Smells (AS) are design patterns in software systems that violate design principles, potentially compromising maintainability and overall quality. As software complexity grows, suboptimal architectural decisions can lead to technical debt, making system evolution more difficult and costly over time.

Early detection of AS is crucial to prevent this accumulation. Among the various types of AS, this study focuses on the Hub-Like Dependency (HL) smell, which occurs when an abstraction has many incoming and outgoing dependencies, forming a hub-like structure in the dependency graph.

Traditional detection methods rely on rule-based systems, which often miss architectural issues requiring a deeper understanding of design context. Large Language Models (LLMs) offer a promising alternative, as they can analyze large amounts of code and have shown potential in detecting code smells, vulnerabilities, and suggesting refactorings. However, no prior study has specifically investigated the use of LLMs for AS detection.

This research explores the detection of HL smells using Google’s Gemini 1.5 Pro and compares its performance with Arcan, a specialized AS detection tool. Additionally, the study evaluates whether LLMs can provide explanations and refactoring suggestions for the detected smells.
DOI: 10.13130/rd_unimi/f0jgu8/5q2x7c
title: Luglio_1928_Pagina_078.jpg

description: Bulletin of 1928/07/20
DOI: 10.13130/rd_unimi/f0jgu8/wj7mzr
title: Luglio_1928_Pagina_079.jpg

description: Bulletin of 1928/07/20
DOI: 10.13130/rd_unimi/f0jgu8/d0vfbq
title: Luglio_1928_Pagina_080.jpg

description: Bulletin of 1928/07/20
DOI: 10.13130/rd_unimi/f0jgu8/i6xc4e
title: Luglio_1928_Pagina_081.jpg

description: Bulletin of 1928/07/21
DOI: 10.13130/rd_unimi/f0jgu8/xqqkcg
title: Luglio_1928_Pagina_082.jpg

description: Bulletin of 1928/07/21
DOI: 10.13130/rd_unimi/f0jgu8/90m0jz
title: Luglio_1928_Pagina_083.jpg

description: Bulletin of 1928/07/21
DOI: 10.13130/rd_unimi/f0jgu8/ejs72l
title: Luglio_1928_Pagina_085.jpg

description: Bulletin of 1928/07/22
DOI: 10.13130/rd_unimi/f0jgu8/p0rq5s
title: Luglio_1928_Pagina_084.jpg

description: Bulletin of 1928/07/21
DOI: 10.13130/rd_unimi/f0jgu8/2arisg
title: Luglio_1928_Pagina_086.jpg

description: Bulletin of 1928/07/22
DOI: 10.13130/rd_unimi/f0jgu8/iaf6dg
title: Luglio_1928_Pagina_087.jpg

description: Bulletin of 1928/07/22
DOI: 10.13130/rd_unimi/f0jgu8/7knccf
title: Luglio_1928_Pagina_088.jpg

description: Bulletin of 1928/07/22
DOI: 10.13130/rd_unimi/f0jgu8/akqc1g
title: Luglio_1928_Pagina_089.jpg

description: Bulletin of 1928/07/23
DOI: 10.13130/rd_unimi/f0jgu8/k0or2s
title: Luglio_1928_Pagina_090.jpg

description: Bulletin of 1928/07/23
DOI: 10.13130/rd_unimi/f0jgu8/njdwnn
title: Luglio_1928_Pagina_091.jpg

description: Bulletin of 1928/07/23
DOI: 10.13130/rd_unimi/f0jgu8/ylirp6
title: Luglio_1928_Pagina_092.jpg

description: Bulletin of 1928/07/23
DOI: 10.13130/rd_unimi/f0jgu8/5njwbv
title: Luglio_1928_Pagina_093.jpg

description: Bulletin of 1928/07/24
DOI: 10.13130/rd_unimi/f0jgu8/oqlhhe
title: Luglio_1928_Pagina_095.jpg

description: Bulletin of 1928/07/24
DOI: 10.13130/rd_unimi/f0jgu8/zqkca8
title: Luglio_1928_Pagina_094.jpg

description: Bulletin of 1928/07/24
DOI: 10.13130/rd_unimi/f0jgu8/fw832m
title: Luglio_1928_Pagina_096.jpg

description: Bulletin of 1928/07/24
DOI: 10.13130/rd_unimi/f0jgu8/kpqmld
title: Luglio_1928_Pagina_097.jpg

description: Bulletin of 1928/07/25
DOI: 10.13130/rd_unimi/f0jgu8/yi2cj9
title: Luglio_1928_Pagina_098.jpg

description: Bulletin of 1928/07/25
DOI: 10.13130/rd_unimi/f0jgu8/ltkdzf
title: Luglio_1928_Pagina_100.jpg

description: Bulletin of 1928/07/25
DOI: 10.13130/rd_unimi/f0jgu8/yah4xs
title: Luglio_1928_Pagina_099.jpg

description: Bulletin of 1928/07/25
DOI: 10.13130/rd_unimi/f0jgu8/kwqezn
title: Luglio_1928_Pagina_101.jpg

description: Bulletin of 1928/07/26
DOI: 10.13130/rd_unimi/f0jgu8/ytbpl4
title: Luglio_1928_Pagina_102.jpg

description: Bulletin of 1928/07/26
DOI: 10.13130/rd_unimi/f0jgu8/uhb0mu
title: Luglio_1928_Pagina_103.jpg

description: Bulletin of 1928/07/26
DOI: 10.13130/rd_unimi/f0jgu8/xoe76w
title: Luglio_1928_Pagina_104.jpg

description: Bulletin of 1928/07/26
DOI: 10.13130/rd_unimi/f0jgu8/apscoh
title: Luglio_1928_Pagina_106.jpg

description: Bulletin of 1928/07/27
DOI: 10.13130/rd_unimi/f0jgu8/hrfsi2
title: Luglio_1928_Pagina_105.jpg

description: Bulletin of 1928/07/27
DOI: 10.13130/rd_unimi/f0jgu8/pognrb
title: Luglio_1928_Pagina_107.jpg

description: Bulletin of 1928/07/27
DOI: 10.13130/rd_unimi/f0jgu8/unpk8d
title: Luglio_1928_Pagina_108.jpg

description: Bulletin of 1928/07/27
DOI: 10.13130/rd_unimi/f0jgu8/7sbxqm
title: Luglio_1928_Pagina_109.jpg

description: Bulletin of 1928/07/28
DOI: 10.13130/rd_unimi/f0jgu8/fexujt
title: Luglio_1928_Pagina_110.jpg

description: Bulletin of 1928/07/28
DOI: 10.13130/rd_unimi/f0jgu8/ik3o4o
title: Luglio_1928_Pagina_111.jpg

description: Bulletin of 1928/07/28
DOI: 10.13130/rd_unimi/f0jgu8/r0v4mt
title: Luglio_1928_Pagina_112.jpg

description: Bulletin of 1928/07/28
DOI: 10.13130/rd_unimi/f0jgu8/qttkv7
title: Luglio_1928_Pagina_113.jpg

description: Bulletin of 1928/07/29
DOI: 10.13130/rd_unimi/f0jgu8/xb73ep
title: Luglio_1928_Pagina_114.jpg

description: Bulletin of 1928/07/29
DOI: 10.13130/rd_unimi/f0jgu8/8q8gnn
title: Luglio_1928_Pagina_116.jpg

description: Bulletin of 1928/07/29
DOI: 10.13130/rd_unimi/f0jgu8/od87oy
title: Luglio_1928_Pagina_115.jpg

description: Bulletin of 1928/07/29
DOI: 10.13130/rd_unimi/f0jgu8/wzuups
title: Luglio_1928_Pagina_117.jpg

description: Bulletin of 1928/07/30
DOI: 10.13130/rd_unimi/f0jgu8/nezgoa
title: Luglio_1928_Pagina_118.jpg

description: Bulletin of 1928/07/30
DOI: 10.13130/rd_unimi/f0jgu8/tzg6jb
title: Luglio_1928_Pagina_119.jpg

description: Bulletin of 1928/07/30
DOI: 10.13130/rd_unimi/f0jgu8/iao22o
title: Luglio_1928_Pagina_120.jpg

description: Bulletin of 1928/07/30
DOI: 10.13130/rd_unimi/f0jgu8/rgkxos
title: Luglio_1928_Pagina_121.jpg

description: Bulletin of 1928/07/31
DOI: 10.13130/rd_unimi/f0jgu8/1c1lcr
title: Luglio_1928_Pagina_122.jpg

description: Bulletin of 1928/07/31
DOI: 10.13130/rd_unimi/f0jgu8/cfdvri
title: Luglio_1928_Pagina_123.jpg

description: Bulletin of 1928/07/31
DOI: 10.13130/rd_unimi/f0jgu8/zlrdqd
title: Luglio_1928_Pagina_124.jpg

description: Bulletin of 1928/07/31
DOI: 10.13130/rd_unimi/f0jgu8/9ng544
title: Maggio_1928_Pagina_001.jpg

description: Bulletin of 1928/05/01
DOI: 10.13130/rd_unimi/f0jgu8/ixnwil
title: Maggio_1928_Pagina_002.jpg

description: Bulletin of 1928/05/01
DOI: 10.13130/rd_unimi/f0jgu8/r5wfzt
title: Maggio_1928_Pagina_003.jpg

description: Bulletin of 1928/05/01
DOI: 10.13130/rd_unimi/f0jgu8/qzx30p
title: Maggio_1928_Pagina_004.jpg

description: Bulletin of 1928/05/01
DOI: 10.13130/rd_unimi/f0jgu8/zfe7sb
title: Maggio_1928_Pagina_005.jpg

description: Bulletin of 1928/05/02
DOI: 10.13130/rd_unimi/f0jgu8/hslgme
title: Maggio_1928_Pagina_006.jpg

description: Bulletin of 1928/05/02
DOI: 10.13130/rd_unimi/f0jgu8/crjyoz
title: Maggio_1928_Pagina_008.jpg

description: Bulletin of 1928/05/02
DOI: 10.13130/rd_unimi/f0jgu8/dtmyi7
title: Maggio_1928_Pagina_007.jpg

description: Bulletin of 1928/05/02
DOI: 10.13130/rd_unimi/f0jgu8/f3gnji
title: Maggio_1928_Pagina_009.jpg

description: Bulletin of 1928/05/03
DOI: 10.13130/rd_unimi/f0jgu8/auyamm
title: Maggio_1928_Pagina_010.jpg

description: Bulletin of 1928/05/03
DOI: 10.13130/rd_unimi/f0jgu8/fre8ei
title: Maggio_1928_Pagina_011.jpg

description: Bulletin of 1928/05/03
DOI: 10.13130/rd_unimi/f0jgu8/ugcued
title: Maggio_1928_Pagina_012.jpg

description: Bulletin of 1928/05/03
DOI: 10.13130/rd_unimi/f0jgu8/zvojif
title: Maggio_1928_Pagina_013.jpg

description: Bulletin of 1928/05/04
DOI: 10.13130/rd_unimi/f0jgu8/se9yhe
title: Maggio_1928_Pagina_014.jpg

description: Bulletin of 1928/05/04
DOI: 10.13130/rd_unimi/f0jgu8/ltjzhd
title: Maggio_1928_Pagina_015.jpg

description: Bulletin of 1928/05/04
DOI: 10.13130/rd_unimi/f0jgu8/rb1eho
title: Maggio_1928_Pagina_016.jpg

description: Bulletin of 1928/05/04
DOI: 10.13130/rd_unimi/f0jgu8/kfm1ir
title: Maggio_1928_Pagina_017.jpg

description: Bulletin of 1928/05/05
DOI: 10.13130/rd_unimi/f0jgu8/mhlgh7
title: Maggio_1928_Pagina_018.jpg

description: Bulletin of 1928/05/05
DOI: 10.13130/rd_unimi/f0jgu8/pagqx1
title: Maggio_1928_Pagina_019.jpg

description: Bulletin of 1928/05/05
DOI: 10.6084/m9.figshare.30883961
title: Supplementary Material for: A case of severe cerebral amyloid angiopathy-related inflammation (CAA-ri) in a 81-year-old woman with rapid cognitive decline

description: Introduction
Cerebral amyloid angiopathy (CAA) is a vasculopathy characterized by amyloid-beta (Aβ) deposition in the walls of the leptomeningeal and cortical blood vessels. In a minority of patients with CAA, presence of amyloid-beta (Aβ) deposition triggers an autoimmune inflammatory reaction, referred to as CAA-related inflammation (CAA-RI). It can present in two forms, either as perivascular CAA-related inflammation (CAA-ri) or as Aβ-related angiitis (ABRA). The mechanism underlying CAA-RI remains unclear. Symptoms are subacute mental disorders and behavioral or cognitive changes, headaches, seizures and focal neurological deﬁcits. Most commonly, CAA-ri is a monophasic illness. Relapses occur often years after the initial presentation and are correlated with corticosteroid tapering or immunosuppression cessation. Treatment is often prolonged, but effective. We present a rare and instructive case with CAA-ri characterized by rapid cognitive decline, therapy resistance and fatal outcome and discuss current literature.

Case presentation
We describe a case of an 81-year-old female who presented with progressive confusion, behaviour alterations, recurrent falls and vomiting since two weeks. There was a rapid cognitive decline and fatal outcome. The diagnosis of a probable CAA-ri was made based on the clinical presentation and brain MR imaging. To allow long-term corticosteroid replacement, azathioprine was initiated for second-line immunosuppression. 

Conclusion 
This case report of CAA-ri describes the diagnostic and therapeutic challenges in an elderly patient with rapid cognitive decline. It highlights the severe nature of the condition, the limitations of available treatments and the importance of early recognition based on the diagnostic criteria and MR imaging and start of the therapy, while acknowledging that outcomes may remain poor despite intervention.
DOI: 10.13130/rd_unimi/f0jgu8/ztjluf
title: Maggio_1928_Pagina_020.jpg

description: Bulletin of 1928/05/05
DOI: 10.6084/m9.figshare.30883961.v1
title: Supplementary Material for: A case of severe cerebral amyloid angiopathy-related inflammation (CAA-ri) in a 81-year-old woman with rapid cognitive decline

description: Introduction
Cerebral amyloid angiopathy (CAA) is a vasculopathy characterized by amyloid-beta (Aβ) deposition in the walls of the leptomeningeal and cortical blood vessels. In a minority of patients with CAA, presence of amyloid-beta (Aβ) deposition triggers an autoimmune inflammatory reaction, referred to as CAA-related inflammation (CAA-RI). It can present in two forms, either as perivascular CAA-related inflammation (CAA-ri) or as Aβ-related angiitis (ABRA). The mechanism underlying CAA-RI remains unclear. Symptoms are subacute mental disorders and behavioral or cognitive changes, headaches, seizures and focal neurological deﬁcits. Most commonly, CAA-ri is a monophasic illness. Relapses occur often years after the initial presentation and are correlated with corticosteroid tapering or immunosuppression cessation. Treatment is often prolonged, but effective. We present a rare and instructive case with CAA-ri characterized by rapid cognitive decline, therapy resistance and fatal outcome and discuss current literature.

Case presentation
We describe a case of an 81-year-old female who presented with progressive confusion, behaviour alterations, recurrent falls and vomiting since two weeks. There was a rapid cognitive decline and fatal outcome. The diagnosis of a probable CAA-ri was made based on the clinical presentation and brain MR imaging. To allow long-term corticosteroid replacement, azathioprine was initiated for second-line immunosuppression. 

Conclusion 
This case report of CAA-ri describes the diagnostic and therapeutic challenges in an elderly patient with rapid cognitive decline. It highlights the severe nature of the condition, the limitations of available treatments and the importance of early recognition based on the diagnostic criteria and MR imaging and start of the therapy, while acknowledging that outcomes may remain poor despite intervention.
DOI: 10.13130/rd_unimi/f0jgu8/el1fau
title: Maggio_1928_Pagina_021.jpg

description: Bulletin of 1928/05/06
DOI: 10.13130/rd_unimi/f0jgu8/abxpfy
title: Maggio_1928_Pagina_022.jpg

description: Bulletin of 1928/05/06
DOI: 10.13130/rd_unimi/f0jgu8/mw0tyl
title: Maggio_1928_Pagina_023.jpg

description: Bulletin of 1928/05/06