cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12094647
title: A poor prognosis in human hepatocellular carcinoma is associated with low expression of DPP4

description: This study aimed to explore the prognostic role of dipeptidyl peptidase 4 (DPP4) expression in hepatocellular carcinoma (HCC). DPP4 expression was measured in formalin-fixed paraffin-embedded specimens that were gathered from 327 HCC patients. Immunohistochemistry analyses were utilized to examine DPP4 expression characteristics and prognostic values (overall survival (OS) and time to recurrence) of DDP4 in HCC tissues. In addition, a patient-derived xenograft (PDX) model was used to assess the correlation between DPP4 expression and tumor growth in vivo. DPP4 was expressed in low levels in HCC tissues in contrast to paired peritumoral tissues (38 cases were down-regulated in a total of 59 cases, 64.4%. P=0.0202). DPP4 expression was significantly correlated with TNM stage (P=0.038), tumor number (P=0.035), and vascular invasion (P=0.024), and significantly reduced in patients who were in TNM stages II and III-V, with multiple tumors, and with microvascular invasion compared to patients with TNM stage I, single tumor, and no microvascular invasion. Notably, HCC tissues with low expression of DPP4 had poor OS (P=0.016) compared with HCC tissues with high expression of DPP4, and results from PDX model showed that tumor growth was significantly faster in HCC patients that lowly expressed DPP4 compared to those with highly expressed DPP4. Our findings suggested that low levels of DPP4 could impact the aggressiveness of HCC and contribute to a poor prognosis.
DOI: 10.6084/m9.figshare.14715070.v1
title: Additional file 18 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens

description: Additional file 17: Table S9. Detailed information on the SNPs associated with the abundance of cecal Parabacteroides.
DOI: 10.6084/m9.figshare.12095028.v1
title: lncRNA ZEB1-AS1 inhibits high glucose-induced EMT and fibrogenesis by regulating the miR-216a-5p/BMP7 axis in diabetic nephropathy

description: Diabetic nephropathy (DN) is one of the leading causes of mortality in diabetic patients. Long non-coding RNA zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) plays a crucial role in the development of various diseases, including DN. However, the molecular mechanism of ZEB1-AS1 in DN pathogenesis remains elusive. An in vitro DN model was established by treating HK-2 cells with high glucose (HG). Quantitative polymerase chain reaction (qRT-PCR) was utilized to detect the expression levels of ZEB1-AS1, microRNA-216a-5p (miR-216a-5p), and bone morphogenetic protein 7 (BMP7). Western blot assay was used to evaluate the protein levels of BMP7, epithelial-to-mesenchymal transition (EMT)-related proteins, and fibrosis markers. Additionally, the interaction among ZEB1-AS1, miR-216a-5p, and BMP7 was predicted by MiRcode (http://www.mircode.org) and starBase 2.0 (omics_06102, omicX), and confirmed by luciferase reporter assay. ZEB1-AS1 and BMP7 were down-regulated, while miR-216a-5p was highly expressed in kidney tissues of DN patients. Consistently, HG treatment decreased the levels of ZEB1-AS1 and BMP7, whereas HG increased miR-216a-5p expression in HK-2 cells in a time-dependent manner. ZEB1-AS1 upregulation inhibited HG-induced EMT and fibrogenesis. Furthermore, ZEB1-AS1 directly targeted miR-216a-5p, and overexpression of miR-216a-5p restored the inhibitory effects of ZEB1-AS1 overexpression on EMT and fibrogenesis. BMP7 was negatively targeted by miR-216a-5p. In addition, ZEB1-AS1 suppressed HG-induced EMT and fibrogenesis by regulating miR-216a-5p and BMP-7. lncRNA ZEB1-AS1 inhibited high glucose-induced EMT and fibrogenesis via regulating miR-216a-5p/BMP7 axis in diabetic nephropathy, providing a potential target for DN therapy.
DOI: 10.6084/m9.figshare.8948855.v1
title: tip dating p6 from Bayesian tip dating reveals heterogeneous morphological clocks in Mesozoic birds

description: Recently, comprehensive morphological datasets including nearly all the well-recognized Mesozoic birds became available, making it feasible for statistically rigorous methods to unveil finer evolutionary patterns during early avian evolution. Here, we exploited the advantage of Bayesian tip dating under relaxed morphological clocks to estimate both the divergence times and evolutionary rates while accounting for their uncertainties. We further subdivided the characters into six body regions (i.e. skull, axial skeleton, pectoral girdle and sternum, forelimb, pelvic girdle and hindlimb) to assess evolutionary rate heterogeneity both along the lineages and across partitions. We observed extremely high rates of morphological character changes during early avian evolution, and the clock rates are quite heterogeneous among the six regions. The branch subtending Pygostylia shows an extremely high rate in the axial skeleton, while the branches subtending Ornithothoraces and Enantiornithes show notably high rates in the pectoral girdle and sternum and moderately high rates in the forelimb. The extensive modifications in these body regions largely correspond to refinement of the flight capability. This study reveals the power and flexibility of Bayesian tip dating implemented in MrBayes to investigate evolutionary dynamics in deep time.
DOI: 10.6084/m9.figshare.12094680.v1
title: Critical role of metabotropic glutamate receptor 4 in bone marrow-derived dendritic cells in the Th17 cell differentiation and the melanogenesis of B16 cells

description: Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) is potentially implicated in vitiligo development and progression. It was recently discovered that metabotropic glutamate receptor 4 (mGluR4) can modulate Th17-mediated adaptive immunity. However, the influence of mGluR4 on melanogenesis of melanocytes has yet to be elucidated. In the present study, we primarily cultured mouse bone marrow-derived dendritic cells (BMDC) and then knocked down and over-expressed mGluR4 using transfection. Transduced BMDC were co-cultured with CD4+ T cells and the expression of Th17-related cytokines were measured. The morphology and melanogenesis of B16 cells were observed after being treated with co-culture medium of CD4+ T cells and transduced BMDC. We found that mGluR4 knockdown did not affect the co-stimulatory CD80 and CD86 upregulation after lipopolysaccharide stimulation but did increase the expression of Th17-related cytokines, and further down-regulated the expression of microphthalmia-associated transcription factor (MITF) and the downstream genes, decreased melanin production, and destroyed the morphology of B16 cells. Conversely, over-expression of mGluR4 reduced the expression of CD80 and CD86, suppressed the production of Th17-related cytokines, increased the expression of MITF, and did not destroy the morphology of B16 cells. Our study confirmed that mGluR4 modulated the Th17 cell polarization and resulted in the alteration of melanogenesis and morphology of B16 cells. Collectively, these findings suggest mGluR4 might be a potent target involved in the immune pathogenesis of vitiligo.
DOI: 10.6084/m9.figshare.12095028
title: lncRNA ZEB1-AS1 inhibits high glucose-induced EMT and fibrogenesis by regulating the miR-216a-5p/BMP7 axis in diabetic nephropathy

description: Diabetic nephropathy (DN) is one of the leading causes of mortality in diabetic patients. Long non-coding RNA zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) plays a crucial role in the development of various diseases, including DN. However, the molecular mechanism of ZEB1-AS1 in DN pathogenesis remains elusive. An in vitro DN model was established by treating HK-2 cells with high glucose (HG). Quantitative polymerase chain reaction (qRT-PCR) was utilized to detect the expression levels of ZEB1-AS1, microRNA-216a-5p (miR-216a-5p), and bone morphogenetic protein 7 (BMP7). Western blot assay was used to evaluate the protein levels of BMP7, epithelial-to-mesenchymal transition (EMT)-related proteins, and fibrosis markers. Additionally, the interaction among ZEB1-AS1, miR-216a-5p, and BMP7 was predicted by MiRcode (http://www.mircode.org) and starBase 2.0 (omics_06102, omicX), and confirmed by luciferase reporter assay. ZEB1-AS1 and BMP7 were down-regulated, while miR-216a-5p was highly expressed in kidney tissues of DN patients. Consistently, HG treatment decreased the levels of ZEB1-AS1 and BMP7, whereas HG increased miR-216a-5p expression in HK-2 cells in a time-dependent manner. ZEB1-AS1 upregulation inhibited HG-induced EMT and fibrogenesis. Furthermore, ZEB1-AS1 directly targeted miR-216a-5p, and overexpression of miR-216a-5p restored the inhibitory effects of ZEB1-AS1 overexpression on EMT and fibrogenesis. BMP7 was negatively targeted by miR-216a-5p. In addition, ZEB1-AS1 suppressed HG-induced EMT and fibrogenesis by regulating miR-216a-5p and BMP-7. lncRNA ZEB1-AS1 inhibited high glucose-induced EMT and fibrogenesis via regulating miR-216a-5p/BMP7 axis in diabetic nephropathy, providing a potential target for DN therapy.
DOI: 10.5517/ccdc.csd.cc2fdgw6
title: CCDC 2246318: Experimental Crystal Structure Determination

description: Related Article: Faizan  Ahmad|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h5450
title: CCDC 2298841: Experimental Crystal Structure Determination

description: Related Article: Jatinder Singh, Richard J. Staples, Jean’ne M. Shreeve|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h6z7y
title: CCDC 2300610: Experimental Crystal Structure Determination

description: Related Article: Alfonso Castineiras, Isabel García-Santos, Manuel Saa|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h6z8z
title: CCDC 2300611: Experimental Crystal Structure Determination

description: Related Article: Alfonso Castineiras, Isabel García-Santos, Manuel Saa|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h6znc
title: CCDC 2300623: Experimental Crystal Structure Determination

description: Related Article: Xiaolin Yu|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h6zzp
title: CCDC 2300633: Experimental Crystal Structure Determination

description: Related Article: Yishu Bao, Jin Zhu, Zonghao Dai, Qikun Zhou, Qingfa Zhou*, and Fulai Yang*|2023|CSD Communication|||
description: Related Article: Yishu Bao, Siyuan Ma, Jin Zhu, Zonghao Dai, Qikun Zhou, Xiuqin Yang, Qingfa Zhou, Fulai Yang|2024|Green Chemistry|26|1356|doi:10.1039/D3GC04699K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h70d5
title: CCDC 2300646: Experimental Crystal Structure Determination

description: Related Article: Iti Gupta|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h722x
title: CCDC 2300698: Experimental Crystal Structure Determination

description: Related Article: Xiaolin Yu|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h723y
title: CCDC 2300699: Experimental Crystal Structure Determination

description: Related Article: Xiaolin Yu|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h7272
title: CCDC 2300703: Experimental Crystal Structure Determination

description: Related Article: Xiaolin Yu|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h7283
title: CCDC 2300704: Experimental Crystal Structure Determination

description: Related Article: Xiaolin Yu|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h73yt
title: CCDC 2300756: Experimental Crystal Structure Determination

description: Related Article: Nikita Swarnkar|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h75qn
title: CCDC 2300811: Experimental Crystal Structure Determination

description: Related Article: Xiaolin Yu|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h75tr
title: CCDC 2300814: Experimental Crystal Structure Determination

description: Related Article: Lee, Hee-Seung, Kim, Jaewook|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2h7j3d
title: CCDC 2301133: Experimental Crystal Structure Determination

description: Related Article: Merzweiler, Kurt, Schmidt, Guntram|2023|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.14715061.v1
title: Additional file 15 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens

description: Additional file 14: Table S7. Co-occurrence network of cecal microbial taxa.
DOI: 10.6084/m9.figshare.14716707
title: Relationship between body composition and bone mineral density in postmenopausal women with Type 2 Diabetes Mellitus

description: Relationship between body composition and bone mineral density in postmenopausal women with Type 2 Diabetes Mellitus
DOI: 10.6084/m9.figshare.14715085.v1
title: Additional file 3 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens

description: Additional file 2: Table S2. Descriptive statistics for host phenotypes.
DOI: 10.48370/ofd/3lxnu0
title: Sorex araneus - 14545, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-09-21, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/ngbzvr
title: Sorex araneus - 95565, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1970-11-17, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/v1po4b
title: Sorex araneus - 20280, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1958-08-23, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/5bjv22
title: Sorex araneus - 99045, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1971-09-07, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/cjynyu
title: Sorex araneus - 2994, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-08-08, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/cwswzb
title: Sorex araneus - 55552, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1966-12-16, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/alhf07
title: Sorex araneus - 4180, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-04-02, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/ioq23g
title: Sorex araneus - 115436, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1974-10-04, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/a08vlp
title: Sorex araneus - 106830, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1972-07-27, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/tl3nxz
title: Sorex araneus - 28188, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1962-06-26, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/ai7qwn
title: Sorex araneus - 150477, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1985-05-10, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/4amfxr
title: Sorex araneus - 162815, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1993-07-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/rdmcie
title: Sorex araneus - 110673, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1973-08-23, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/cqivkm
title: Sorex araneus - 2701, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-07-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/svslmi
title: Sorex araneus - 8752, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-06-11, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/kfcook
title: Sorex araneus - 9502, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1955-06-28, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/vk4cn4
title: Sorex araneus - 3537, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-09-04, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/whkxqf
title: Sorex araneus - 4370, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1954-05-21, in: Białowieża National Park, Poland. Material type:
DOI: 10.48370/ofd/wryscz
title: Sorex araneus - 29217, Zoological collection of the Mammal Research Institute, PAS

description: Sorex araneus (Common shrew) from Zoological collection of the Mammal Research Institute, PAS. Collected 1962-09-18, in: Białowieża National Park, Poland. Material type: