cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11946348.v2
title: The role of cellular prion protein in lipid metabolism in the liver

description: Cellular prion protein (PrPC) is a plasma membrane glycophosphatidylinositol-anchored protein and it is involved in multiple functions, including neuroprotection and oxidative stress. So far, most of the PrPC functional research is done in neuronal tissue or cell lines; the role of PrPC in non-neuronal tissues such as liver is only poorly understood. To characterize the role of PrPC in the liver, a proteomics approach was applied in the liver tissue of PrPC knockout mice. The proteome analysis and biochemical validations showed an excessive fat accumulation in the liver of PrPC knockout mice with a change in mRNA expression of genes linked to lipid metabolism. In addition, the higher Bax to Bcl2 ratio, up-regulation of tgfb1 mRNA expression in PrPC knockout mice liver, further showed the evidences of metabolic disease. Over-expression of PrPC in fatty acid-treated AML12 hepatic cell line caused a reduction in excessive intracellular fat accumulation; shows association of PrPC levels and lipid metabolism. Therefore, based on observation of excessive fat globules in the liver of ageing PrPC knockout mice and the reduction of fat accumulation in AML12 cell line with PrPC over-expression, the role of PrPC in lipid metabolism is described.
DOI: 10.6084/m9.figshare.11825877
title: Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study

description: Chronic wasting disease is a fatal, horizontally transmissible prion disease of cervid species that has been reported in free-ranging and farmed animals in North America, Scandinavia, and Korea. Like other prion diseases, CWD susceptibility is partly dependent on the sequence of the prion protein encoded by the host’s <i>PRNP</i> gene; it is unknown if variations in <i>PRNP</i> have any meaningful effects on other aspects of health. Conventional diagnosis of CWD relies on ELISA or IHC testing of samples collected post-mortem, with recent efforts focused on antemortem testing approaches. We report on the conclusions of a study evaluating the role of antemortem testing of rectal biopsies collected from over 570 elk in a privately managed herd, and the results of both an amplification assay (RT-QuIC) and conventional IHC among animals with a several <i>PRNP</i> genotypes. Links between <i>PRNP</i> genotype and potential markers of evolutionary fitness, including pregnancy rates, body condition, and annual return rates were also examined. We found that the RT-QuIC assay identified significantly more CWD positive animals than conventional IHC across the course of the study, and was less affected by factors known to influence IHC sensitivity – including follicle count and PRNP genotype. We also found that several evolutionary markers of fitness were not adversely correlated with specific <i>PRNP</i> genotypes. While the financial burden of the disease in this herd was ultimately unsustainable for the herd owners, our scientific findings and the hurdles encountered will assist future CWD management strategies in both wild and farmed elk and deer.
DOI: 10.6084/m9.figshare.11825877.v1
title: Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study

description: Chronic wasting disease is a fatal, horizontally transmissible prion disease of cervid species that has been reported in free-ranging and farmed animals in North America, Scandinavia, and Korea. Like other prion diseases, CWD susceptibility is partly dependent on the sequence of the prion protein encoded by the host’s <i>PRNP</i> gene; it is unknown if variations in <i>PRNP</i> have any meaningful effects on other aspects of health. Conventional diagnosis of CWD relies on ELISA or IHC testing of samples collected post-mortem, with recent efforts focused on antemortem testing approaches. We report on the conclusions of a study evaluating the role of antemortem testing of rectal biopsies collected from over 570 elk in a privately managed herd, and the results of both an amplification assay (RT-QuIC) and conventional IHC among animals with a several <i>PRNP</i> genotypes. Links between <i>PRNP</i> genotype and potential markers of evolutionary fitness, including pregnancy rates, body condition, and annual return rates were also examined. We found that the RT-QuIC assay identified significantly more CWD positive animals than conventional IHC across the course of the study, and was less affected by factors known to influence IHC sensitivity – including follicle count and PRNP genotype. We also found that several evolutionary markers of fitness were not adversely correlated with specific <i>PRNP</i> genotypes. While the financial burden of the disease in this herd was ultimately unsustainable for the herd owners, our scientific findings and the hurdles encountered will assist future CWD management strategies in both wild and farmed elk and deer.
DOI: 10.6084/m9.figshare.11946348.v1
title: The role of cellular prion protein in lipid metabolism in the liver

description: Cellular prion protein (PrPC) is a plasma membrane glycophosphatidylinositol-anchored protein and it is involved in multiple functions, including neuroprotection and oxidative stress. So far, most of the PrPC functional research is done in neuronal tissue or cell lines; the role of PrPC in non-neuronal tissues such as liver is only poorly understood. To characterize the role of PrPC in the liver, a proteomics approach was applied in the liver tissue of PrPC knockout mice. The proteome analysis and biochemical validations showed an excessive fat accumulation in the liver of PrPC knockout mice with a change in mRNA expression of genes linked to lipid metabolism. In addition, the higher Bax to Bcl2 ratio, up-regulation of tgfb1 mRNA expression in PrPC knockout mice liver, further showed the evidences of metabolic disease. Over-expression of PrPC in fatty acid-treated AML12 hepatic cell line caused a reduction in excessive intracellular fat accumulation; shows association of PrPC levels and lipid metabolism. Therefore, based on observation of excessive fat globules in the liver of ageing PrPC knockout mice and the reduction of fat accumulation in AML12 cell line with PrPC over-expression, the role of PrPC in lipid metabolism is described.
DOI: 10.6084/m9.figshare.13489335
title: Raw Data and Analysis Files for A Biphasic Approach for Characterizing Tensile, Compressive, and Hydraulic Properties of the Sclera from A biphasic approach for characterizing tensile, compressive and hydraulic properties of the sclera

description: Raw compression testing data and all subsequent steps of analysis for extracting poroelastic properties.
DOI: 10.6084/m9.figshare.13489335.v1
title: Raw Data and Analysis Files for A Biphasic Approach for Characterizing Tensile, Compressive, and Hydraulic Properties of the Sclera from A biphasic approach for characterizing tensile, compressive and hydraulic properties of the sclera

description: Raw compression testing data and all subsequent steps of analysis for extracting poroelastic properties.
DOI: 10.34740/kaggle/dsv/1781929
title: COVID-19 Indonesia Dataset
DOI: 10.6084/m9.figshare.13489344
title: Murray et al Dataset 201226.sav

description: Online questionnaire study exploring thought suppression and self-compassion as serial mediators of the relationship between adult attachment orientation and depressive symptoms.
DOI: 10.21227/vn4y-fe61
title: Coronavirus (COVID-19) Geo-tagged Tweets Dataset

description: This dataset contains IDs and sentiment scores of the geo-tagged tweets related to the COVID-19 pandemic. The tweets are captured by an on-going project deployed at https://live.rlamsal.com.np. The model monitors the real-time Twitter feed for coronavirus-related tweets using 90+ different keywords and hashtags that are commonly used while referencing the pandemic. Complying with Twitter's content redistribution policy, only the tweet IDs are shared. You can re-construct the dataset by hydrating these IDs. The tweet IDs in this dataset belong to the tweets tweeted providing an exact location.The paper associated with this dataset is available here: Design and analysis of a large-scale COVID-19 tweets dataset-------------------------------------Related datasets: (a) Coronavirus (COVID-19) Tweets Sentiment Trend (Global)(b) Tweets Originating from India During COVID-19 Lockdowns-------------------------------------Below is the quick overview of this dataset.— Dataset name: GeoCOV19Tweets Dataset— Number of tweets : 287,114 tweets— Coverage : Global— Language : English (EN)— Dataset usage terms : By using this dataset, you agree to (i) use the content of this dataset and the data generated from the content of this dataset for non-commercial research only, (ii) remain in compliance with Twitter's Developer Policy and (iii) cite the following paper:Lamsal, R. Design and analysis of a large-scale COVID-19 tweets dataset. Applied Intelligence (2020). https://doi.org/10.1007/s10489-020-02029-z— Primary dataset : Coronavirus (COVID-19) Tweets Dataset (COV19Tweets Dataset)— Dataset updates : Everyday— Active keywords and hashtags: keywords.tsvPlease visit this page (primary dataset) for details regarding the collection date and time (and other notes) of each CSV file present in this dataset.
DOI: 10.17632/xcdynybp57.1
title: Data for: Clinical Diagnostic Predictive Score for Meckel Diverticulum

description: Data collection spread sheet
DOI: 10.6084/m9.figshare.13372721
title: Problematic Social Media Usage and Anxiety among University Students during the COVID-19 Pandemic: The Mediating Role of Psychological Capital and the Moderating Role of Academic Burnout

description: Problematic Social Media Usage and Anxiety among University Students during the COVID-19 Pandemic: The Mediating Role of Psychological Capital and the Moderating Role of Academic Burnout
DOI: 10.6084/m9.figshare.13372721.v2
title: Problematic Social Media Usage and Anxiety among University Students during the COVID-19 Pandemic: The Mediating Role of Psychological Capital and the Moderating Role of Academic Burnout

description: Problematic Social Media Usage and Anxiety among University Students during the COVID-19 Pandemic: The Mediating Role of Psychological Capital and the Moderating Role of Academic Burnout
DOI: 10.6084/m9.figshare.13372721.v1
title: Problematic Social Media Usage and Anxiety among University Students during the COVID-19 Pandemic: The Mediating Role of Psychological Capital and the Moderating Role of Academic Burnout

description: Problematic Social Media Usage and Anxiety among University Students during the COVID-19 Pandemic: The Mediating Role of Psychological Capital and the Moderating Role of Academic Burnout
DOI: 10.6084/m9.figshare.13489356
title: raw data of TCGA-BRCA

description: Raw data downloaded from TCGA.
DOI: 10.5517/ccdc.csd.cc24gtp4
title: CCDC 1980456: Experimental Crystal Structure Determination

description: Related Article: Stephan Ludwig, Kai Helmdach, Mareike Hüttenschmidt, Elisabeth Oberem, Jabor Rabeah, Alexander Villinger, Ralf Ludwig, Wolfram W. Seidel|2020|Chem.-Eur.J.|26|16811|doi:10.1002/chem.202003120
DOI: 10.5517/ccdc.csd.cc24gtq5
title: CCDC 1980457: Experimental Crystal Structure Determination

description: Related Article: Stephan Ludwig, Kai Helmdach, Mareike Hüttenschmidt, Elisabeth Oberem, Jabor Rabeah, Alexander Villinger, Ralf Ludwig, Wolfram W. Seidel|2020|Chem.-Eur.J.|26|16811|doi:10.1002/chem.202003120
DOI: 10.5517/ccdc.csd.cc24gtr6
title: CCDC 1980458: Experimental Crystal Structure Determination

description: Related Article: Stephan Ludwig, Kai Helmdach, Mareike Hüttenschmidt, Elisabeth Oberem, Jabor Rabeah, Alexander Villinger, Ralf Ludwig, Wolfram W. Seidel|2020|Chem.-Eur.J.|26|16811|doi:10.1002/chem.202003120
DOI: 10.5517/ccdc.csd.cc24p332
title: CCDC 1986483: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc24p310
title: CCDC 1986481: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc24p365
title: CCDC 1986486: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc24vpxm
title: CCDC 1991871: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc24xm3t
title: CCDC 1993706: Experimental Crystal Structure Determination

description: Related Article: Holger Elsen, Jens Langer, Michael Wiesinger, Sjoerd Harder|2020|Organometallics|39|4238|doi:10.1021/acs.organomet.0c00226
DOI: 10.5517/ccdc.csd.cc24xm4v
title: CCDC 1993707: Experimental Crystal Structure Determination

description: Related Article: Holger Elsen, Jens Langer, Michael Wiesinger, Sjoerd Harder|2020|Organometallics|39|4238|doi:10.1021/acs.organomet.0c00226
DOI: 10.5517/ccdc.csd.cc24xm5w
title: CCDC 1993708: Experimental Crystal Structure Determination

description: Related Article: Holger Elsen, Jens Langer, Michael Wiesinger, Sjoerd Harder|2020|Organometallics|39|4238|doi:10.1021/acs.organomet.0c00226
DOI: 10.5517/ccdc.csd.cc24xm6x
title: CCDC 1993709: Experimental Crystal Structure Determination

description: Related Article: Holger Elsen, Jens Langer, Michael Wiesinger, Sjoerd Harder|2020|Organometallics|39|4238|doi:10.1021/acs.organomet.0c00226
DOI: 10.5517/ccdc.csd.cc24xm7y
title: CCDC 1993710: Experimental Crystal Structure Determination

description: Related Article: Holger Elsen, Jens Langer, Michael Wiesinger, Sjoerd Harder|2020|Organometallics|39|4238|doi:10.1021/acs.organomet.0c00226
DOI: 10.5517/ccdc.csd.cc25g0m9
title: CCDC 2009470: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0nb
title: CCDC 2009471: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0pc
title: CCDC 2009472: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0qd
title: CCDC 2009473: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0rf
title: CCDC 2009474: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0sg
title: CCDC 2009475: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0th
title: CCDC 2009476: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.5517/ccdc.csd.cc25g0vj
title: CCDC 2009477: Experimental Crystal Structure Determination

description: Related Article: Wolfram Feuerstein, Christof Holzer, Xin Gui, Lilly Neumeier, Wim Klopper, Frank Breher|2020|Chem.-Eur.J.|26|17156|doi:10.1002/chem.202003271
DOI: 10.6084/m9.figshare.12966863
title: The Synoptic Impacts on the Convection Initiation of a Warm-sector Heavy Rainfall Event over Coastal South China Prior to the Monsoon Onset: A Numerical Modeling Study

description: Shared data for: The Synoptic Impacts on the Convection Initiation of a Warm-sector Heavy Rainfall Event over Coastal South China Prior to the Monsoon Onset: A Numerical Modeling Study submitted to JGR:Atmosphere
DOI: 10.6084/m9.figshare.12966863.v6
title: The Synoptic Impacts on the Convection Initiation of a Warm-sector Heavy Rainfall Event over Coastal South China Prior to the Monsoon Onset: A Numerical Modeling Study

description: Shared data for: The Synoptic Impacts on the Convection Initiation of a Warm-sector Heavy Rainfall Event over Coastal South China Prior to the Monsoon Onset: A Numerical Modeling Study submitted to JGR:Atmosphere
DOI: 10.6084/m9.figshare.12966863.v5
title: The Synoptic Impacts on the Convection Initiation of a Warm-sector Heavy Rainfall Event over Coastal South China Prior to the Monsoon Onset: A Numerical Modeling Study

description: Shared data for: The Synoptic Impacts on the Convection Initiation of a Warm-sector Heavy Rainfall Event over Coastal South China Prior to the Monsoon Onset: A Numerical Modeling Study submitted to JGR:Atmosphere
DOI: 10.34740/kaggle/dsv/1782375
title: LUFlow Network Intrusion Detection Data Set
DOI: 10.4119/unibi/2946079
title: Reference-based QUantification Of gene Dispensability (QUOD) - test dataset

description: # Test set for QUOD (Reference-based QUantification Of gene Dispensability) ## Background: Dispensability of genes in a phylogenetic lineage, e.g. a species, genus, or higher-level clade, is gaining relevance as most genome sequencing projects move to a pangenome level. Most analyses classify genes as core genes, which are present in (almost) all investigated individual genomes, and dispensable genes, which only occur in a single or a few investigated genomes. The binary classification as ‘core’ or ‘dispensable’ is often based on arbitrary cutoffs of presence/absence in the analysed genomes. Instead of classifying a gene as core or dispensable, QUOD assigns a dispensability score to each gene. Hence, QUOD facilitates the identification of candidate dispensable genes which often underlie lineage-specific adaptation to varying environmental conditions. ## Test set: The test dataset for QUOD comprises genomic reads of four randomly selected accessions of the *Arabidopsis thaliana* Nordborg set. The reads were retrieved from the Sequence Read Archive (SRA) and mapped against the AthNd1_v2c reference genome sequence [1] using bowtie2 [2]. To reduce the size of the files, the first Mbp of Chr1 was extracted. All BAM files provided here are already sorted and should be used as input for QUOD which is available on GitHub: https://github.com/ksielemann/QUOD. A dispensability score is calculated for each gene. Optionally, the results can be visualized as a colored histogram and a box plot.<br> <br> ##### References: <sub>[1] Pucker B, et al. A chromosome-level sequence assembly reveals the structure of the Arabidopsis thaliana Nd-1 genome and its gene set. PloS one 14.5 (2019): e0216233.</sub> <sub>[2] Langmead B, Salzberg S. Fast gapped-read alignment with Bowtie 2. Nature Methods. 2012, 9:357-359.</sub>
DOI: 10.4119/unibi/2938185
title: Description and mapping positions of BoeWGS1.0 contigs

description: Belongs to the study 'A Partially Phase-separated Genome Sequence Assembly of the Vitis rootstock ‘Börner’ (_Vitis riparia_ x _Vitis cinerea_) and its Exploitation for Marker Development and Targeted Mapping' which contains additional information about this dataset.
DOI: 10.4119/unibi/2941430
title: Dataset describing RNA editing sites in the chloroplast genome of 'Boerner' (Vitis riparia x Vitis cinerea)

description: The dataset contains a table listing the RNA editing sites of the ‘Börner’ chloroplast genome sequence (cp_Boe). In addition, coding sequences (CDS) and protein sequences from the chloroplast genes subject to RNA editing (edited and not edited versions) are included. The data belong to the study 'Genome sequences of both organelles of the grapevine rootstock cultivar ‘Börner’' which contains additional information about this dataset.
DOI: 10.4119/unibi/2941437
title: Dataset describing RNA editing sites in the mitochondrial genome of 'Boerner' (Vitis riparia x Vitis cinerea)

description: The dataset contains a table listing the RNA editing sites of the 'Börner' mitochondrial genome sequence (mt_Boe). In addition, coding sequences (CDS) and protein sequences from the mitochondrial genes subject to RNA editing (edited and not edited versions) are provided. The data belong to the study 'Genome sequences of both organelles of the grapevine rootstock cultivar ‘Börner’' which contains additional information about this dataset.
DOI: 10.4119/unibi/2937697
title: Genome assemblies of Musa acuminata Dwarf Cavendish

description: Please see https://doi.org/10.1101/691923 for a description of the data set and applied methods.
DOI: 10.4119/unibi/2936278
title: Small sequence variants between the Musa acuminata cultivars Dwarf Cavendish and DH Pahang

description: Please see https://doi.org/10.1101/691923 for a description of the data set and applied methods.
DOI: 10.4119/unibi/2934226
title: RNA-Seq read coverage depth of splice sites in animals

description: RNA-Seq reads of 32 animal species were mapped to the corresponding genome sequence. The coverage around splice sites within the protein coding sequence of genes is listed. Each line represents one intron within a protein coding sequence. Species name and gene ID are provided in the first two columns. Next, the number of reads mapped to the very 3' end of the upstream exon, 5' and 3' ends of the intron, and the very 5' end of the downstream exon are given. The last two columns provide the terminal dinucleotide sequences of an intron. This analysis was performed according to Pucker & Brockington, 2018 (https://doi.org/10.1186/s12864-018-5360-z) using Python scripts reported therein (https://doi.org/10.5281/zenodo.2586989). Analysed species: Acanthaster_planci, Alligator_mississippiensis, Apis_cerana, Bemisia_tabaci, Brugia_malayi, Camponotus_floridanus, Danio_rerio, Daphnia_magna, Drosophila_melanogaster, Equus_canallus, Eurytemora_affinis, Felis_catus, Fundulus_heteroclitus, Gallus_gallus, Homo_sapiens, Hydra_vulgaris, Ictalurus_punctatus, Ictidomys_tridecemlineatus, Leptinotarsa_decemlineata, Macaca_fascicularis, Maylandia_zebra, Melanochromis_auratus, Meleagris_gallopavo, Mizuhopecten_yessoensis, Mus_musculus, Nasonia_vitripennis, Nematostella_vectensis, Oikopleura_dioica, Oryctolagus_cuniculus, Parasteatoda_tepidariorum, Pomacea_canaliculata, Python_bivittatus