DOI: 10.25550/1-x5kg
title: Gene summary for MSX1

description: #### Genome Browser Links: [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&db=mm9&position=chr5%3A38211730-38215824&refGene=pack&hgFind_matches=NM_010835) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&db=mm10&position=chr5%3A37820491-37824585&refGene=pack&hgFind_matches=NM_010835) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&db=hg18&position=chr4%3A4912293-4916561&refGene=pack&hgFind_matches=NM_002448) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&db=hg19&position=chr4%3A4861392-4865660&refGene=pack&hgFind_matches=NM_002448) #### Reference Images: | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| | ![Image](/hatrac/facebase/genesummaries/Msx1_anterior_E12.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Msx1_anterior_E13.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Msx1_anterior_E14.5.jpg) | ![Image](/hatrac/facebase/genesummaries/Msx1_anterior_E15.5.jpg) | #### Gene expression in the secondary palate: _Msx1_ is expressed in the mesenchyme of the anterior region of the developing palate, in both nasal and oral sides. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_coronal_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_coronal_E13.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_coronal_E14.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_coronal_E15.5.jpg){width=100} | | **Intraoral** | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_oral_E12.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_oral_E13.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_oral_E14.5.jpg){width=100} | ![ImageWithSize](/hatrac/facebase/genesummaries/Msx1_oral_E15.5.jpg){width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral ![Image](/hatrac/facebase/genesummaries/FF7F7F.gif) All mesenchyme (ON axis) ![Image](/hatrac/facebase/genesummaries/ECB177.gif) Anterior mesenchyme (AP axis) #### Sources: - Zhang et al. (2002) [Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis.](http://www.ncbi.nlm.nih.gov/pubmed/12163415) Development 129(17):4135-46. - Unpublished data from [Chai Lab, University of Southern California.](http://face.usc.edu/) #### Gene expression in the mandibular and maxillary arches: _Msx1_ is expressed in the mesenchyme of the distal region of the maxillary and mandibular arches at E10.5. At E12.5, it is expressed in the odontologenic and osteogenic mesenchyme in the mandible (only the osteogenic mesenchyme is depicted). At E14.5, Msx1 is still expressed in the osteogenic progenitors and tooth mesenchyme. | E10.5 | E12.5 | E14.5 | |-------|-------|-------| | ![ImageWithSize](/hatrac/facebase/genesummaries/msx1-10.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/msx1-12.5.jpg){width=280 height=214} | ![ImageWithSize](/hatrac/facebase/genesummaries/msx1-14.5.jpg){width=280 height=214} | | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Distal mesenchyme | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Odontogenic and osteogenic | ![Image](/hatrac/facebase/genesummaries/c1b2d1.gif) Osteogenic mesenchyme | | | mesenchyme | ![Image](/hatrac/facebase/genesummaries/ece6f0.gif) Tooth mesenchyme | #### Sources: - Liu et al. Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development 2003 130: 6375-6385. - Unpublished data from [Chai's Lab, University of Southern California.](http://face.usc.edu/). #### Related Datasets: - [All FaceBase data related to MSX1](/data/recordset/#1/isa:dataset/*::facets::N4IghgdgJiBcDaoDOB7ArgJwMYFM6JAEsIAjdafIpMEAGhCjABcwkcmB9Acxwhw8Ys2nQlA4AzANY4AniAC6AX1qh0TMmgoIqNeoNbtuvfjz4TpcpXpIAPDDnEL6WABYpCuJJQASAcQByAMKwAOwAzACcAIywCopKQA) #### External Links: - [Msx1 homeobox, msh-like 1 [ Mus musculus ]](http://www.ncbi.nlm.nih.gov/gene/17701) - [MSX1 msh homeobox 1 [ Homo sapiens ]](http://www.ncbi.nlm.nih.gov/gene/4487) - [msh Homeobox 1](http://www.genecards.org/cgi-bin/carddisp.pl?gene=MSX1&search=msx1) - [Msx1 Wikipedia](http://en.wikipedia.org/wiki/MSX1) - [Eurexpress](http://www.eurexpress.org/ee/databases/tdbsearch?mode=search&standardAtlas=on&getStandardAtlas=yes&multistageAtlas=on&getMultistageAtlas=yes&groupSelection=Group_All&findEverything=no&anatomySetNames=0&expressionStrengthOperator=g&expressionStrengthValue=&coverageOperator=g&coverageValue=&page=&searchField=All&searchValue=msx1&Submit=Go)