cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24310222.v1
title: Supplementary Material for: Cardiac Output Changes during Renal Replacement Therapy: A Scoping Review

description: Introduction: Renal Replacement Therapy (RRT) is associated with hypotension. However, its impact on cardiac output (CO) is less understood. We aimed to describe current knowledge of CO monitoring and changes during RRT. Methods: We searched Medline, Embase and Cochrane from 01/01/2000 to 31/01/2023 using Covidence for studies of intermittent hemodialysis (IHD) and continuous RRT (CRRT) with at least three CO measurements during treatment. Two independent reviewers screened citations and a third resolved disagreements. The findings did not allow meta-analysis and are presented descriptively. Results: We screened 3285 articles and included 48 (37 during IHD, nine during CRRT, and two during both). Non-invasive devices (electrical conductivity techniques and finger cuff pulse contour) were the most common CO measurement techniques (21 studies). The median baseline cardiac index in IHD studies was 3 L/min/m2 (95% CI, 2.7 to 3.39). Among the 88 patient cohorts studied, a decrease in CO occurred in 63 (72%). In 16 cohorts, the decrease was severe (&gt; 25%). Changes in blood pressure (BP) were not concordant in extent or direction with changes in CO. The decrease in CO correlated weakly with ultrafiltration rate (r = - 0.3, p = 0.05) and strongly with changes in systemic vascular resistance (SVR) (r = - 0.6, p &lt; 0.001). Discussion/Conclusion: There are limited data on CO changes during RRT. However, a decrease in CO appeared common and was marked in one of five patient cohorts. Such decreases often occurred without BP changes and were associated with increased SVR.
DOI: 10.6084/m9.figshare.14152570.v1
title: An Arabidopsis gene expression matrix derived from large-scaled RNA-Seq datasets

description: The dataset contains a gene expression matrix to be used with the EXPLICIT package to construct an gene expression predictor. It has 24545 RNA-Seq samples with 38194 genes in total. <br>Two versions of the matrix are provided. It is recommended to use the smaller version first (At.matrix.demo.h5) to get familiar with the EXPLICIT package, and then change to the full version (At.matrix.full.h5). The smaller matrix contains 5000 samples randomly selected from all 24545 samples.<br><br>At.matrix.demo.h5<br>|--expression_log2cpm -------- (5000 samples [row] X 38194 genes [col])<br>|--gene_name ------------------ ( for the 38194 genes)<br>|--rnaseq_id ------------------- (for the 5000 samples)<br>|--idx_tf_gene ------- (specifying TF genes used for model construction)<br>|--idx_target_gene --- (specifying target genes used for model construction)<br>|--independent_samples_for_validation<br> &gt;&gt;&gt;|--expression_log2cpm ------ (2 samples [row] X 38194 genes [col])<br> &gt;&gt;&gt;|--gene_name ----------------- (for the 38194 genes)<br> &gt;&gt;&gt;|--sample_id ---------------- (for the 2 RNA-Seq samples)<br>At.matrix.full.h5<br>|--expression_log2cpm -------- (24545 samples [row] X 38194 genes [col])<br>|--gene_name ------------------ (for the 38194 genes)<br>|--rnaseq_id ------------------- (for the 24545 samples)<br>|--idx_tf_gene ------- (specifying TF genes used for model construction)<br>|--idx_target_gene --- (specifying target genes used for model construction)<br>|--independent_samples_for_validation<br> &gt;&gt;&gt;|--expression_log2cpm ------ (2 samples [row] X 38194 genes [col])<br> &gt;&gt;&gt;|--gene_name ----------------- (for the 38194 genes)<br> &gt;&gt;&gt;|--sample_id ---------------- (for the 2 RNA-Seq samples)
DOI: 10.6084/m9.figshare.15070317.v1
title: Tabla 1 - Guía de temas para los grupos focales

description: Tabla 2 - Guía de temas para los grupos focales, usada para el estudio "Perspectivas docentes para una agenda crítica en educación mediática post COVID-19. Estudio comparativo en Latinoamérica".
DOI: 10.6084/m9.figshare.3552543.v1
title: Appendix B. Deviations in the performance of leading indicators when measured in time series due to methodological issues.

description: Deviations in the performance of leading indicators when measured in time series due to methodological issues.
DOI: 10.6084/m9.figshare.19634520.v1
title: Supplementary Material for: SP1 Promotes HDAC4 Expression and Inhibits HMGB1 Expression to Reduce Intestinal Barrier Dysfunction, Oxidative Stress, and Inflammatory Response after Sepsis

description: As a serious and elusive syndrome caused by infection, sepsis causes a high rate of mortality around the world. Our investigation aims at exploring the role and possible mechanism of specificity protein-1 (SP1) in the development of sepsis. A mouse model of sepsis was established by cecal ligation perforation, and a cellular model was stimulated by lipopolysaccharide (LPS), followed by determination of the SP1 expression. It was determined that SP1 was poorly expressed in the intestinal tissues of septic mice and LPS-treated cells. Next, we examined the interactions among SP1, histone deacetylase 4 (HDAC4), and high mobility group box 1 (HMGB1) and found that SP1 bound to the HDAC4 promoter to upregulate its expression, thereby promoting the deacetylation of HMGB1. Meanwhile, gain- or loss-of-function approaches were applied to evaluate the intestinal barrier dysfunction, oxidative stress, and inflammatory response. Overexpression of SP1 or underexpression of HMGB1 was observed to reduce intestinal barrier dysfunction, oxidative stress, and inflammatory injury. Collectively, these experimental data provide evidence reporting that SP1 could promote the HDAC4-mediated HMGB1 deacetylation to reduce intestinal barrier dysfunction, oxidative stress, and inflammatory response induced by sepsis, providing a novel therapeutic target for sepsis prevention and treatment.
DOI: 10.17870/bathspa.20987713.v1
title: Resource list on the tourism experience

description: This is a list of resources about tourism experience.
DOI: 10.6084/m9.figshare.11790342.v1
title: Dataset for "Similarities in the behaviour of dance followers among honey bee species suggest a conserved mechanism of dance communication"

description: Two datasets containing the dance follower numbers and dance follower body orientation with respect to the dancer for the manuscript "Similarities in the behaviour of dance followers among honey bee species suggests a conserved mechanism of dance communication".The first contains the number of followers present in each zone around the dancer, during three different phases of the waggle run (Start, Middle and End) for all dances analysed from all three species.The second contains the body orientation of all the followers identified in the first dataset.Refer to the manuscript uploaded in bioRxiv for more details (https://biorxiv.org/cgi/content/short/2020.02.02.931345v1).<br><br><br>
DOI: 10.25403/upresearchdata.22012643.v1
title: Morphological and genetic characterization of Mozambican indigenous cattle populations

description: The dataset contains quantitative and qualitative information on 614 unrelated individual cattle purposefully sampled in twenty-three villages in four provinces. Moreover, plink files containing 49,996 SNP genotypes of three cattle breeds of Mozambique were added. Family codes: ANG = Angone LAN = Landim TET = Tete These data underpin a thesis titled 'Genetic characterization of Mozambican indigenous cattle populations'.
DOI: 10.6084/m9.figshare.20067173.v1
title: Cheney et al 2022 Statistics table

description: Table of the reported relationships and p-values.
DOI: 10.6084/m9.figshare.21975641.v1
title: Supplementary Material for: Nonintentional N-Acetylcysteine Overdose Associated with Cerebral Edema and Brain Death

description: N-Acetylcysteine is the established treatment of acetaminophen toxicity. This medication’s complex dosing schedule engenders a high incidence of medication errors. While nuisance side effects are common, only rare case reports describe serious outcomes associated with N-Acetylcysteine administration, all of which take place in the setting of non-intentional N-Acetylcysteine overdose. This case report contributes to a small but growing literature that suggests that large N-Acetylcysteine overdose may have devastating outcomes. We describe a 15-year-old female who presented with Stage III Acetaminophen toxicity and who received a non-intentional six-fold overdose of intravenous N-Acetylcysteine due to a medication prescribing error. During the N-Acetylcysteine infusion dosing error the patient had clinical deterioration including seizure followed by cerebral edema and brain herniation that progressed to brain death. She developed agitation and worsening headache within 2 hours of the dosing error and progressed to seizure and intubation 14 hours into the dosing error. Although possibly due to hepatic encephalopathy, at the time she developed fixed dilated pupils her lactate, INR, aspartate aminotransferase, and alanine aminotransferase had all improved. On review of the literature, other case reports of seizures (n=4) and cerebral edema with brain herniation (n=3) were found, suggesting our patient was not an isolated case. Clinicians need to be aware of the common occurrence of dosing errors for N-Acetylcysteine infusions. We suggest institutions review their N-Acetylcysteine ordering, dosing, and mixing protocols in order to avoid similar rare errors in the future. Iatrogenic overdose of N-Acetylcysteine can cause seizure, cerebral edema, and brain death.
DOI: 10.6084/m9.figshare.5709709.v1
title: S1. Dataset

description: <i>Psychosis, vulnerability, white noise, first episode psychosis.<br></i>
DOI: 10.6084/m9.figshare.19107287.v1
title: Supplementary Material for: Efficacy and Safety of Anti-Interleukin-5 Therapies in Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

description: <b><i>Introduction:</i></b> The efficacy and safety of benralizumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) remain unresolved, and relevant meta-analyses are lacking. Additionally, mepolizumab has been evaluated in far fewer patients, and the evidence is unclear. We conducted a meta-analysis to identify evidence gaps that will guide future investigation of therapies targeting interleukin (IL)-5 signaling (anti-IL-5Rα or anti-IL-5) for CRSwNP. <b><i>Methods:</i></b> We performed a systematic review and meta-analysis that were registered with PROSPERO (No. CRD42021276867). A comprehensive search was performed in PubMed, Embase, Web of Science, and the Cochrane Library on September 2, 2021. Only randomized controlled trials (RCTs) assessing anti-IL-5 treatments (anti-IL-5Rα or anti-IL-5) in adult patients for CRSwNP were included. <b><i>Results:</i></b> Seven RCTs with 799 patients evaluating the efficacy and safety of treatments targeting IL-5 pathway (benralizumab [anti-IL-5Rα], mepolizumab, and reslizumab [anti-IL-5]) were included. The overall pooled meta-analysis showed that anti-IL-5 treatments were associated with a significantly better nasal polyp score (weighted mean difference [WMD]: −0.71; 95% confidence interval [CI]: [−0.87, −0.55]; <i>p</i> &lt; 0.00001). Anti-IL-5 treatments were associated with a significantly better nasal congestion score (WMD: −1.73; 95% CI: [−2.29, −1.16]; <i>p</i> &lt; 0.00001). Anti-IL-5 treatments were associated with a significantly better Sino-Nasal Outcome Test (SNOT-22) score (WMD: −11.30; 95% CI: [−14.77, −7.83]; <i>p</i> &lt; 0.00001). The overall pooled meta-analysis showed that anti-IL-5 treatments were associated with a significantly better University of Pennsylvania Smell Identification Test (UPSIT) score (WMD: 2.09; 95% CI: [0.42, 3.77]; <i>p</i> = 0.01). Anti-IL-5 treatments significantly reduced the loss of smell score in the overall pooled meta-analysis (WMD: −1.38; 95% CI: [−1.97, −0.79]; <i>p</i> &lt; 0.00001). In the overall pooled meta-analysis, anti-IL-5 treatments showed no difference with the placebo in the risk of adverse events (AEs; risk ratio [RR]: 1.01; 95% CI: [−0.93, 1.09]; <i>p</i> = 0.83) and serious AEs (SAEs; RR: 0.73; 95% CI: [0.40, 1.34]; <i>p</i> = 0.32). <b><i>Conclusion:</i></b> This systematic review and meta-analysis identified that anti-IL-5 treatments significantly improved the size of nasal polyps, health-related quality of life, and sense of smell in moderate to severe CRSwNP, and they were safe and well tolerated.
DOI: 10.6084/m9.figshare.14916684.v1
title: SOSEN-KG dump

description: Dump of the current version of the SOSEN-KG, including automatically extracted metadata from &gt; 10.000 Zenodo entries, enriched by applying the Software Metadata Extraction Framework (SOMEF) on their GitHub README files.<br>Another separate file with the keywords extracted from descriptions, titles, etc., can be used for keyword search on top of the KG<br>
DOI: 10.6084/m9.figshare.14844765.v1
title: Supplementary Material for: The Influence of Seasonal Availability of Young Leaves on Dietary Niche Separation in Two Ecologically Similar Folivorous Lemurs

description: Traditional socio-ecological models consider that folivorous primates experience limited feeding competition due to the low quality, high abundance, and even distribution of leaves. Evidence from several folivorous species that experience similar constraints to frugivores does not support this hypothesis. The sympatric lemur genera <i>Avahi</i> (Indriidae) and <i>Lepilemur</i> (Lepilemuridae) are good models to understand how food availability constrains folivores since they are both nocturnal, folivorous, and have a comparable body mass. Here we investigate how two nocturnal folivorous primates, <i>Avahi meridionalis</i> and <i>Lepilemur fleuretae</i>, living in the lowland rain forest of Tsitongambarika, South-East Madagascar, partition their dietary niche and are influenced by seasonality of young leaves. To account for food availability, we collected annual phenological data on 769 trees from 200 species. We also collected behavioural data on 5 individuals per lemur species from August 2015 to July 2016 via continuous focal sampling. We found the phenological profile to be seasonal with peaks of leaf flushing, flowering, and fruiting occurring in the austral summer. The two species showed limited dietary overlap (37% rich period, 6% lean period), and <i>A. meridionalis</i> showed higher feeding time and longer daily distances travelled during the rich period. <i>Lepilemur fleuretae</i> showed a dietary shift during the lean period, relying more on mature leaves (73.3% during the lean period, 13.5% during the rich period) but maintaining similar activity levels between seasons. The time spent feeding on food items by <i>A. meridionalis</i> was positively correlated with the nitrogen content and negatively correlated with polyphenols during the rich period. We highlighted a clear effect of the seasonality of young leaves on the diet, nutritional content, activity patterns, and daily distances travelled by two folivorous species, which can be linked to nutrient balancing and time-minimising versus energy-maximising strategies.
DOI: 10.6084/m9.figshare.28870940.v1
title: <b>Impact of Solar Energy Infrastructure and Ecovoltaic Management on Semi-Arid Grassland Carbon Cycling</b>

description: Data collected from a three-year field experiment in Colorado, USA to investigate the effects of photovoltaic panel microclimates and ecovoltaic management practices (interseeding native species and irrigation) on above and belowground net primary productivity (ANPP and BNPP), soil organic carbon (SOC) stocks, and soil CO<sub>2</sub> flux.
DOI: 10.6084/m9.figshare.10000577.v1
title: Supplementary Material for: A Meta-Analysis of the Impact of Obesity, Metabolic Syndrome, Insulin Resistance, and Microbiome on the Diagnosis of Barrett’s Esophagus

description: <b><i>Background and Aim:</i></b> The etiology and pathogenesis of Barrett’s esophagus (BE) have been widely studied during recent decades. However, the association between BE and possible risk factors, including abdominal obesity (AO), metabolic syndrome (MetS), insulin resistance (IR), and the microbiome has not reached a consensus and lacks a systematic assessment. The purpose of our study is to evaluate, quantify, and summarize the association between these factors and BE risk. <b><i>Methods:</i></b> A systematic search of Pubmed, Embase, and Cochrane Library databases was performed to identify relevant studies before September 2018. Studies were estimated with the OR, the weighted mean difference (WMD), and the 95% CI by using a random effects model. Subgroup analysis and publication bias were also performed. <b><i>Results:</i></b> A total of 46 citations were included in the analysis, and 119,273 subjects were analyzed (AO 13, MetS 15, IR 9, and microbiome: 9). The pooled results showed that AO (<i>p</i> &lt; 0.01, OR 1.30, 95% CI 1.11–1.52, <i>I</i><sup>2</sup> = 31.9%), MetS (<i>p</i> &lt; 0.01, OR 1.68, 95% CI 1.40–2.01, <i>I</i><sup>2</sup> = 87.6%), and IR (<i>p</i> &lt; 0.01, WMD 0.23, 95% CI 0.11–0.35, <i>I</i><sup>2</sup> = 55.8%) were all significantly associated with an increased risk of BE, but except for the microbiome (<i>p</i> &gt; 0.05, OR 1.27, 95% CI 0.66–2.43, <i>I</i><sup>2</sup> = 46.7%). In addition, subgroup analyses were stratified by waist-to-hip ratio, waist circumference, body mass index, diagnosis criteria, strain type, geographical region, and study design, respectively. Moreover, we observed no evidence of publication bias in Egger’s and Begg’s tests. <b><i>Conclusions:</i></b> Our study reveals that AO, MetS, and IR are significantly associated with BE risk, except for the microbiome. The mechanism of BE induced by 3 risk factors should be further explored.
DOI: 10.6084/m9.figshare.19076948.v1
title: Supplementary Material for: Polymorphism in Thymidylate Synthase Gene Predicts Survival and Toxicity in North Indian Lung Cancer Patients Undergoing Platinum-Based Doublet Chemotherapy

description: Abstract Background: With an estimated 1.8 million deaths, lung cancer is one of the widely reported malignancies, with substantial morbidity and mortality rates. Thymidylate synthase (TS) is an important drug target for platinum-based doublet chemotherapy as it is the only de novo source of thymidylate production in the cell. TS polymorphisms in the 5'UTR of Thymidylate synthase enhancer region (TSER) 2R/3R and 3'- UTR 1494del6 are investigated in this study. Methods: A total of 700 lung cancer patients with platinum-based doublet chemotherapy were recruited in this study. TSER (2R/3R) and TS 1494del6 polymorphisms in North Indian lung cancer patients were examined, and statistical analysis was performed. Results: According to our findings, patients with the wild genotype (2R/2R) for the TSER polymorphism had a longer median survival time as compared to patients harboring the mutant type genotype (3R/3R) [MST=9.77 vs. 7.57 months; p=0.04]. On the contrary, patients with the mutant 14946del6 polymorphism (-6/-6) had a longer survival time than patients with the wild-type genotype (+6/+6) [MST=7.23 vs. 9 months]. Further, our findings elucidated that the patients with heterozygous genotype (2R3R) for TSER polymorphism had a 2.30-fold increased risk of developing leukopenia (AOR=2.30, 95% CI=0.96-5.52; p=0.05). A substantial risk of 5.14-fold constipation was found in heterozygous genotype (2R3R) when intermediate grade 2 toxicity was compared with low toxicity (grade 1) (p=0.007).An increased risk of nausea/vomiting was observed in patients with mutant genotype (-6/-6bp) for 1494 ins/del6 polymorphism compared to patients with wild-type genotype (+6/+6bp) (AOR= 2.77; 95%CI=1.10-6.96, p=0.03). Conclusion: According to our findings, TSER and the 1494del6 polymorphism may operate as a prognostic marker in lung cancer patients receiving platinum-based chemotherapy. Furthermore, TS polymorphisms may influence the onset of platinum-related toxicity, such as hematological and gastrointestinal toxicity. These findings might facilitate therapeutic decisions for individualized therapy in lung cancer patients. Keywords: Lung cancer, Thymidylate synthase, survival, platinum-based chemotherapy, polymorphism, toxicity
DOI: 10.6084/m9.figshare.21006490.v2
title: Vegans and vegetarians have higher orthorexic traits than omnivores and choose food for reasons including ethics and weight control

description: SPSS sav. file with de-identified data <br> <br>
DOI: 10.6084/m9.figshare.12619151.v1
title: Data_SR_Peyton.xlsx

description: Data set for a systematic review that analyzes the effectiveness of Peyton's teaching approach in the training of health professionals.
DOI: 10.6084/m9.figshare.16829053.v4
title: Birth weight and Smoking

description: Birth weight and Smoking during pregnancy
DOI: 10.6084/m9.figshare.22853645.v1
title: SATINN - demo files and neural networks (r.230516)

description: Demo data for the development of SATINN - a neural network-based approach to analyzing mouse seminiferous images. This rar file contains the components to run SATINN for the first time: a sample test image as well as the pre-trained neural networks. As SATINN is still in a developmental phase, these data may eventually become outdated. We will continually release updated demo data along with SATINN releases, so please make sure you have the latest files!
DOI: 10.6084/m9.figshare.879956.v4
title: site_climate.mat, a Matlab data file containing site locations and climate data used in McWethy et al. (2013)

description: Matlab .mat file containing location of charcoal sites in Version 2 of the Global Charcoal Database<br>(http://www.gpwg.org/gpwgdb.html), and associated climate data.
DOI: 10.6084/m9.figshare.3518738.v1
title: Appendix A. Seven component PARAFAC model loadings and split-half validation.

description: Seven component PARAFAC model loadings and split-half validation.
DOI: 10.6084/m9.figshare.6874871.v4
title: EEG anticipation of random high and low arousal faces and sounds

description: Materials related to the paper "EEG anticipation of random high and low arousal faces and sounds" available at https://psyarxiv.com/un9ed<br>Auditory stimuli must be requested to the corresponding author due to copyright restrictions.<br><br><br>
DOI: 10.6084/m9.figshare.11912409.v1
title: Supplementary Material for: Agreement of Cardiac Output Measurements between Bioreactance and Transthoracic Echocardiography in Preterm Infants during the Transitional Phase: A Single-Centre, Prospective Study

description: <b><i>Introduction:</i></b> Bioreactance cardiac output (CO) monitors are able to non-invasively and continuously monitor CO. However, as a novel tool to measure CO, it must be proven to be accurate and precise. <b><i>Objective:</i></b> To determine the agreement between CO measured with a bioreactance monitor and transthoracic echocardiography-derived left ventricular output parameters in preterm infants. <b><i>Methods:</i></b> This is a prospective observational study in 63 preterm neonates with non-invasive respiratory support, not requiring inotrope support. The infants underwent continuous bioreactance monitoring of CO and stroke volume (SV) and simultaneous transthoracic echocardiography every 6 h until 72 h of life. <b><i>Results:</i></b> The agreement between bioreactance and transthoracic echocardiography, for both SV and CO, was poor. The percentage error was 67.5% for SV and 71.6% for CO. The mean error was 60.4% for SV and 69.8% for CO. Bias was affected by numerous variables. After correcting for time, CO and SV bias were significantly affected by the presence of an open patent ductus arteriosus and the level of CO. <b><i>Conclusion:</i></b> Bioreactance cannot be considered interchangeable with transthoracic echocardiography to measure CO in preterm infants during the transition phase. Agreement between bioreactance and other CO metrics should be assessed before concluding its accuracy or inaccuracy in neonates.