cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11353391.v2
title: FIXATIONS AND RECOGNITION OF DYNAMIC AND STATIC FACIAL EMOTIONS IN SOCIAL ANXIETY

description: Estudos demonstram um viés atencional negativo para o reconhecimento de emoções além da hipervigilância por parte dos sujeitos com ansiedade social (AS) ao observarem uma face. Entretanto, as evidências acerca desses estímulos em condições dinâmicas e estáticas são escassas. O presente estudo buscou investigar o reconhecimento de expressões faciais dinâmicas e estáticas associado com a varredura ocular em sujeitos com sintomas de AS e controles. Participaram 56 voluntários, sendo 28 com sintomas de AS – grupo experimental (GE) e 28 controles – grupo controle (GC). As emoções de alegria, nojo, raiva e tristeza foram apresentadas na condição estática e dinâmica nas intensidades de 25, 50, 75 e 100%. Durante o reconhecimento foi realizada a captura binocular das fixações, sendo analisados o número e o tempo médio de duração. ANOVA para medidas repetidas revelou que apenas para tristeza 25% o GE apresentou maior taxa de acerto (p &lt; 0,001; η<sup>2</sup> = 0,216). Nas faces dinâmicas o GE fixou mais vezes do que o GC (p &lt; 0,001; η<sup>2</sup> = 0,179), porém o GC teve fixações mais duradouras do que o GE (p = 0,016; η<sup>2</sup> = 0,103). Ocorreram fixações mais duradouras do GC também na estática (p &lt; 0,001; η<sup>2</sup> = 0,357). O grupo com sintomas de AS apresentou hipervigilância para fotografias e vídeos, mas isso não influenciou no reconhecimento das expressões apresentadas nessas condições.
DOI: 10.6084/m9.figshare.11353391
title: FIXATIONS AND RECOGNITION OF DYNAMIC AND STATIC FACIAL EMOTIONS IN SOCIAL ANXIETY

description: Estudos demonstram um viés atencional negativo para o reconhecimento de emoções além da hipervigilância por parte dos sujeitos com ansiedade social (AS) ao observarem uma face. Entretanto, as evidências acerca desses estímulos em condições dinâmicas e estáticas são escassas. O presente estudo buscou investigar o reconhecimento de expressões faciais dinâmicas e estáticas associado com a varredura ocular em sujeitos com sintomas de AS e controles. Participaram 56 voluntários, sendo 28 com sintomas de AS – grupo experimental (GE) e 28 controles – grupo controle (GC). As emoções de alegria, nojo, raiva e tristeza foram apresentadas na condição estática e dinâmica nas intensidades de 25, 50, 75 e 100%. Durante o reconhecimento foi realizada a captura binocular das fixações, sendo analisados o número e o tempo médio de duração. ANOVA para medidas repetidas revelou que apenas para tristeza 25% o GE apresentou maior taxa de acerto (p &lt; 0,001; η<sup>2</sup> = 0,216). Nas faces dinâmicas o GE fixou mais vezes do que o GC (p &lt; 0,001; η<sup>2</sup> = 0,179), porém o GC teve fixações mais duradouras do que o GE (p = 0,016; η<sup>2</sup> = 0,103). Ocorreram fixações mais duradouras do GC também na estática (p &lt; 0,001; η<sup>2</sup> = 0,357). O grupo com sintomas de AS apresentou hipervigilância para fotografias e vídeos, mas isso não influenciou no reconhecimento das expressões apresentadas nessas condições.
DOI: 10.6084/m9.figshare.11353391.v6
title: FIXATIONS AND RECOGNITION OF DYNAMIC AND STATIC FACIAL EMOTIONS IN SOCIAL ANXIETY

description: Estudos demonstram um viés atencional negativo para o reconhecimento de emoções além da hipervigilância por parte dos sujeitos com ansiedade social (AS) ao observarem uma face. Entretanto, as evidências acerca desses estímulos em condições dinâmicas e estáticas são escassas. O presente estudo buscou investigar o reconhecimento de expressões faciais dinâmicas e estáticas associado com a varredura ocular em sujeitos com sintomas de AS e controles. Participaram 56 voluntários, sendo 28 com sintomas de AS – grupo experimental (GE) e 28 controles – grupo controle (GC). As emoções de alegria, nojo, raiva e tristeza foram apresentadas na condição estática e dinâmica nas intensidades de 25, 50, 75 e 100%. Durante o reconhecimento foi realizada a captura binocular das fixações, sendo analisados o número e o tempo médio de duração. ANOVA para medidas repetidas revelou que apenas para tristeza 25% o GE apresentou maior taxa de acerto (p &lt; 0,001; η<sup>2</sup> = 0,216). Nas faces dinâmicas o GE fixou mais vezes do que o GC (p &lt; 0,001; η<sup>2</sup> = 0,179), porém o GC teve fixações mais duradouras do que o GE (p = 0,016; η<sup>2</sup> = 0,103). Ocorreram fixações mais duradouras do GC também na estática (p &lt; 0,001; η<sup>2</sup> = 0,357). O grupo com sintomas de AS apresentou hipervigilância para fotografias e vídeos, mas isso não influenciou no reconhecimento das expressões apresentadas nessas condições.
DOI: 10.6084/m9.figshare.11353391.v5
title: FIXATIONS AND RECOGNITION OF DYNAMIC AND STATIC FACIAL EMOTIONS IN SOCIAL ANXIETY

description: Estudos demonstram um viés atencional negativo para o reconhecimento de emoções além da hipervigilância por parte dos sujeitos com ansiedade social (AS) ao observarem uma face. Entretanto, as evidências acerca desses estímulos em condições dinâmicas e estáticas são escassas. O presente estudo buscou investigar o reconhecimento de expressões faciais dinâmicas e estáticas associado com a varredura ocular em sujeitos com sintomas de AS e controles. Participaram 56 voluntários, sendo 28 com sintomas de AS – grupo experimental (GE) e 28 controles – grupo controle (GC). As emoções de alegria, nojo, raiva e tristeza foram apresentadas na condição estática e dinâmica nas intensidades de 25, 50, 75 e 100%. Durante o reconhecimento foi realizada a captura binocular das fixações, sendo analisados o número e o tempo médio de duração. ANOVA para medidas repetidas revelou que apenas para tristeza 25% o GE apresentou maior taxa de acerto (p &lt; 0,001; η<sup>2</sup> = 0,216). Nas faces dinâmicas o GE fixou mais vezes do que o GC (p &lt; 0,001; η<sup>2</sup> = 0,179), porém o GC teve fixações mais duradouras do que o GE (p = 0,016; η<sup>2</sup> = 0,103). Ocorreram fixações mais duradouras do GC também na estática (p &lt; 0,001; η<sup>2</sup> = 0,357). O grupo com sintomas de AS apresentou hipervigilância para fotografias e vídeos, mas isso não influenciou no reconhecimento das expressões apresentadas nessas condições.
DOI: 10.6084/m9.figshare.11353232
title: Supplementary Material for: Predictors of Significant Coronary Artery Disease in Patients with Cerebral Artery Atherosclerosis

description: <b><i>Objective:</i></b> There are few existing data on the status of coronary artery disease (CAD) in patients with atherosclerosis of the cerebral artery detected by brain imaging studies. We aimed to analyze the predictors of asymptomatic angiographically significant CAD detected by simultaneous cerebral and coronary angiography. <b><i>Methods:</i></b> This retrospective cohort study screened data obtained between August 2009 and April 2019; 11,047 patients underwent cerebral angiography for atherosclerotic change (&gt;50% stenosis or aneurysm) seen in brain magnetic resonance angiography (MRA) or computed tomography angiography (CTA) at a single center by endovascular neurosurgeon’s decision. Of these, 700 patients including 622 patients who underwent simultaneous coronary and cerebral angiography and 78 patients who underwent coronary angiography within a month were enrolled. We investigated the characteristics and predictors of angiographically significant CAD (&gt;50% stenosis). Furthermore, we also analyzed the major adverse cardiovascular and cerebrovascular events (MACCE), including all-cause death, myocardial infarction, and stroke for 5 years. <b><i>Results:</i></b> The frequency of significant CAD was 59% (413/700), the mean age was 68.9 ± 10.3 years, and 60.6% were male. During mean follow-up of 50 months, the MACCE rate of our whole cohort was significantly higher in the CAD group (21.5%) than in the non-CAD group (14.6%; hazard ratio 1.65, 95% CI 1.17–2.33, <i>p</i> value = 0.005). Considering that the embolic stroke is less associated with atherosclerotic change, our predictive model of significant CAD was made without embolic stroke (<i>n</i> = 599). In our multivariate model 2 including univariate &lt;0.1, the independent predictors of significant CAD were male (OR 1.62, 95% CI 1.11–2.35, <i>p</i> = 0.012), diabetes mellitus (OR 1.81, 95% CI 1.22–2.68, <i>p</i> = 0.003), previous stroke (OR 1.63, 95% CI 1.02–2.60, <i>p</i> = 0.039), low ankle-brachial index (ABI; &lt;0.9; OR 3.25, 95% CI 1.21–8.73, <i>p</i> = 0.019), left ventricular ejection fraction (EF) &lt;50% on echocardiography (OR 2.82, 95% CI 1.25–6.35, <i>p</i> = 0.012), troponin I or T positive (OR 2.76, 95% CI 1.69–4.53, <i>p</i> &lt; 0.001), and complex features on cerebral angiography (OR 2.73, 95% CI 1.78–4.19, <i>p</i> &lt; 0.001). <b><i>Conclusions:</i></b> Accurate coronary evaluation by coronary angiography might be considered when patients with atherosclerotic cerebral artery detected on brain MRA or CTA planned cerebral angiography were male or have diabetes mellitus, previous stroke, low ABI (&lt;0.9), left ventricular EF &lt;50% on echocardiography, troponin I or T positivity, and complex features on cerebral angiography.
DOI: 10.6084/m9.figshare.11353226
title: Supplementary Material for: The Effect of Body Mass Index on Outcome after Endovascular Treatment in Acute Ischemic Stroke Patients: A Post Hoc Analysis of the MR CLEAN Trial

description: <b><i>Background:</i></b> Though obesity is a well-known risk factor for vascular disease, the impact of obesity on stroke outcome has been disputed. Several studies have shown that obesity is associated with better functional outcome after stroke. Whether obesity influences the benefit of endovascular treatment (EVT) in stroke patients is unknown. We evaluated the association between body mass index (BMI) and outcome in acute ischemic stroke patients with large vessel ­occlusion (LVO), and assessed whether BMI affects the ­benefit of EVT. <b><i>Methods:</i></b> This is a post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands trial (­ISRCTN10888758). BMI was used as a continuous and categorical variable, distinguishing underweight and normal weight (BMI &lt;25), overweight (BMI 25–30), and obesity (BMI ≥30). We used multivariable ordinal logistic regression analysis to estimate the association of BMI with functional outcome (shift analysis), assessed with modified Rankin Scale (mRs) at 90 days. The impact of BMI on EVT effect was tested by the use of a multiplicative interaction term. <b><i>Results:</i></b> Of 366 patients, 160 (44%) were underweight or normal weight, 145 (40%) overweight, and 61 (17%) were obese. In multivariable analysis with BMI as a continuous variable, we found a shift toward better functional outcome with higher BMI (mRS adjusted common OR 1.04; 95% CI 1.0–1.09), and mortality was inversely related to BMI (aOR 0.92; 95% CI 0.85–0.99). Safety analysis showed that higher BMI was associated with lower risk of stroke progression (aOR 0.92, 95% CI 0.87–0.99). Additional analysis showed no interaction between BMI and EVT effect on functional outcome, mortality, and other safety outcomes. <b><i>Conclusion:</i></b> Our study confirms the effect of obesity on outcome in acute ischemic stroke patients with LVO, meaning better functional outcome, lower mortality, and lower risk of stroke progression for patients with higher BMI. As we found no interaction between BMI and EVT effect, all BMI classes may expect the same benefit from EVT.
DOI: 10.6084/m9.figshare.11353232.v1
title: Supplementary Material for: Predictors of Significant Coronary Artery Disease in Patients with Cerebral Artery Atherosclerosis

description: <b><i>Objective:</i></b> There are few existing data on the status of coronary artery disease (CAD) in patients with atherosclerosis of the cerebral artery detected by brain imaging studies. We aimed to analyze the predictors of asymptomatic angiographically significant CAD detected by simultaneous cerebral and coronary angiography. <b><i>Methods:</i></b> This retrospective cohort study screened data obtained between August 2009 and April 2019; 11,047 patients underwent cerebral angiography for atherosclerotic change (&gt;50% stenosis or aneurysm) seen in brain magnetic resonance angiography (MRA) or computed tomography angiography (CTA) at a single center by endovascular neurosurgeon’s decision. Of these, 700 patients including 622 patients who underwent simultaneous coronary and cerebral angiography and 78 patients who underwent coronary angiography within a month were enrolled. We investigated the characteristics and predictors of angiographically significant CAD (&gt;50% stenosis). Furthermore, we also analyzed the major adverse cardiovascular and cerebrovascular events (MACCE), including all-cause death, myocardial infarction, and stroke for 5 years. <b><i>Results:</i></b> The frequency of significant CAD was 59% (413/700), the mean age was 68.9 ± 10.3 years, and 60.6% were male. During mean follow-up of 50 months, the MACCE rate of our whole cohort was significantly higher in the CAD group (21.5%) than in the non-CAD group (14.6%; hazard ratio 1.65, 95% CI 1.17–2.33, <i>p</i> value = 0.005). Considering that the embolic stroke is less associated with atherosclerotic change, our predictive model of significant CAD was made without embolic stroke (<i>n</i> = 599). In our multivariate model 2 including univariate &lt;0.1, the independent predictors of significant CAD were male (OR 1.62, 95% CI 1.11–2.35, <i>p</i> = 0.012), diabetes mellitus (OR 1.81, 95% CI 1.22–2.68, <i>p</i> = 0.003), previous stroke (OR 1.63, 95% CI 1.02–2.60, <i>p</i> = 0.039), low ankle-brachial index (ABI; &lt;0.9; OR 3.25, 95% CI 1.21–8.73, <i>p</i> = 0.019), left ventricular ejection fraction (EF) &lt;50% on echocardiography (OR 2.82, 95% CI 1.25–6.35, <i>p</i> = 0.012), troponin I or T positive (OR 2.76, 95% CI 1.69–4.53, <i>p</i> &lt; 0.001), and complex features on cerebral angiography (OR 2.73, 95% CI 1.78–4.19, <i>p</i> &lt; 0.001). <b><i>Conclusions:</i></b> Accurate coronary evaluation by coronary angiography might be considered when patients with atherosclerotic cerebral artery detected on brain MRA or CTA planned cerebral angiography were male or have diabetes mellitus, previous stroke, low ABI (&lt;0.9), left ventricular EF &lt;50% on echocardiography, troponin I or T positivity, and complex features on cerebral angiography.
DOI: 10.25392/leicester.data.11353184
title: University of Leicester COAF compliance report 2018/2019

description: This spreadsheet lists the article level data detailing how the University of Leicester has used the Charity Open Access Fund (COAF) between 01 October 2018 and 30 September 2019.
DOI: 10.25392/leicester.data.11353184.v1
title: University of Leicester COAF compliance report 2018/2019

description: This spreadsheet lists the article level data detailing how the University of Leicester has used the Charity Open Access Fund (COAF) between 01 October 2018 and 30 September 2019.
DOI: 10.6084/m9.figshare.11353157
title: Late Cretaceous stratigraphy in the Mudurnu–Göynük Basin (Turkey) and inferences on sea-level change in the Late Campanian to Early Maastrichtian

description: Supplementary Table 1. Calcareous nannofossil data from the Göynük composite section. Semiquantitative estimates of abundances are based on specimens per field of view (FOV): (A) abundant &gt; 10 specimen/FOV, (C) common = 2–10 specimen/FOV, (F) few — 1 specimen per 1 to 9 FOW, (R) rare — 1 specimen per 10–100 FOV. Preservation was assessed using a scale ranging from (G) good — no clear indication of overgrowths or dissolution, (M) moderate — signs of overgrowths or dissolution, most of the specimens could still be identified at least at the genus level, (P) poor — abundant and strong overgrowths or dissolution, determination at species and genus level often questionable. Species abundance highlighted grey indicates ranges of biostratigraphicylly significant marker taxa, blue indicates cooler-water nannofossil species.
DOI: 10.6084/m9.figshare.11353157.v1
title: Late Cretaceous stratigraphy in the Mudurnu–Göynük Basin (Turkey) and inferences on sea-level change in the Late Campanian to Early Maastrichtian

description: Supplementary Table 1. Calcareous nannofossil data from the Göynük composite section. Semiquantitative estimates of abundances are based on specimens per field of view (FOV): (A) abundant &gt; 10 specimen/FOV, (C) common = 2–10 specimen/FOV, (F) few — 1 specimen per 1 to 9 FOW, (R) rare — 1 specimen per 10–100 FOV. Preservation was assessed using a scale ranging from (G) good — no clear indication of overgrowths or dissolution, (M) moderate — signs of overgrowths or dissolution, most of the specimens could still be identified at least at the genus level, (P) poor — abundant and strong overgrowths or dissolution, determination at species and genus level often questionable. Species abundance highlighted grey indicates ranges of biostratigraphicylly significant marker taxa, blue indicates cooler-water nannofossil species.
DOI: 10.6084/m9.figshare.11353085
title: Dataset for: Metabolomic Investigations of the Temporal Effects of Exposure to Pharmaceuticals and Personal Care Products and their Mixture in the Eastern Oyster (Crassostrea virginica)

description: The eastern oyster (Crassostrea virginica) supports a large aquaculture industry and is a keystone species along the Atlantic seaboard. Native oysters are routinely exposed to a complex mixture of contaminants that increasingly includes pharmaceuticals and personal care products (PPCPs). Unfortunately, the biological effects of chemical mixtures on oysters are poorly understood. Untargeted GC-MS metabolomics was utilized to quantify the response of oysters exposed to fluoxetine, N,N-diethyl-meta-toluamide (DEET), 17α-ethynylestradiol (EE2), diphenhydramine and their mixture. Oysters were exposed to 1 µg/L of each chemical or mixture for ten days, followed by an eight-day depuration period. Adductor muscle (n = 14/treatment) was sampled at days 0, 1, 5, 10 and 18. Trajectory analysis illustrated that metabolic effects and class separation of the treatments varied at each time point, and that overall, the oysters were only able to partially recover from these exposures post-depuration. Altered metabolites were associated with cellular energetics (i.e. Krebs cycle intermediates), as well as amino acid metabolism and the urea cycle. Exposure to these PPCPs also affected metabolic pathways associated with anaerobic metabolism, osmotic stress and oxidative stress, in addition to the physiological effects from each chemical’s postulated mechanism of action. Following depuration, there were fewer metabolites altered, but none of the treatments returned to their initial control values, indicating that metabolic disruptions were long-lasting. Interestingly, the mixture did not directly cluster with individual treatments in the scores plot from partial least squares discriminant analysis and many of its affected metabolic pathways were not well-predicted from the individual treatments. This research highlights the utility of untargeted metabolomics in developing exposure biomarkers for compounds with differing modes of action in bivalves.
DOI: 10.6084/m9.figshare.11353094
title: <i>Mc1r</i> genotype and plumage colouration in highly polymorphic jackal buzzards, <i>Buteo rufofuscus</i>

description: Evolution is driven by natural selection acting on variable phenotypic traits. Understanding the molecular basis of those traits is crucial for elucidating the mechanisms of natural selection. The southern African jackal buzzard (<i>Buteo rufofuscus</i>) displays extreme plumage colour polymorphism, with colouration on the chest varying from dark black to pale white. In a number of birds and other vertebrates, genetic variation at the melanocortin-1 receptor (<i>Mc1r</i>) gene is associated with melanin-based colour variation. Here, the <i>Mc1r</i> gene was sequenced from 12 jackal buzzard individuals displaying three distinct colour morphs (dark, intermediate and pale). A single nucleotide change was found, which although it resulted in an amino acid change, was shared by all jackal buzzards irrespective of colour morph. Although the <i>Mc1r</i> has played an important role in colour polymorphism in other species, in this study no association between <i>Mc1r</i> genotype and plumage polymorphism in jackal buzzards was found.
DOI: 10.6084/m9.figshare.11353085.v1
title: Dataset for: Metabolomic Investigations of the Temporal Effects of Exposure to Pharmaceuticals and Personal Care Products and their Mixture in the Eastern Oyster (Crassostrea virginica)

description: The eastern oyster (Crassostrea virginica) supports a large aquaculture industry and is a keystone species along the Atlantic seaboard. Native oysters are routinely exposed to a complex mixture of contaminants that increasingly includes pharmaceuticals and personal care products (PPCPs). Unfortunately, the biological effects of chemical mixtures on oysters are poorly understood. Untargeted GC-MS metabolomics was utilized to quantify the response of oysters exposed to fluoxetine, N,N-diethyl-meta-toluamide (DEET), 17α-ethynylestradiol (EE2), diphenhydramine and their mixture. Oysters were exposed to 1 µg/L of each chemical or mixture for ten days, followed by an eight-day depuration period. Adductor muscle (n = 14/treatment) was sampled at days 0, 1, 5, 10 and 18. Trajectory analysis illustrated that metabolic effects and class separation of the treatments varied at each time point, and that overall, the oysters were only able to partially recover from these exposures post-depuration. Altered metabolites were associated with cellular energetics (i.e. Krebs cycle intermediates), as well as amino acid metabolism and the urea cycle. Exposure to these PPCPs also affected metabolic pathways associated with anaerobic metabolism, osmotic stress and oxidative stress, in addition to the physiological effects from each chemical’s postulated mechanism of action. Following depuration, there were fewer metabolites altered, but none of the treatments returned to their initial control values, indicating that metabolic disruptions were long-lasting. Interestingly, the mixture did not directly cluster with individual treatments in the scores plot from partial least squares discriminant analysis and many of its affected metabolic pathways were not well-predicted from the individual treatments. This research highlights the utility of untargeted metabolomics in developing exposure biomarkers for compounds with differing modes of action in bivalves.
DOI: 10.6084/m9.figshare.11353094.v1
title: <i>Mc1r</i> genotype and plumage colouration in highly polymorphic jackal buzzards, <i>Buteo rufofuscus</i>

description: Evolution is driven by natural selection acting on variable phenotypic traits. Understanding the molecular basis of those traits is crucial for elucidating the mechanisms of natural selection. The southern African jackal buzzard (<i>Buteo rufofuscus</i>) displays extreme plumage colour polymorphism, with colouration on the chest varying from dark black to pale white. In a number of birds and other vertebrates, genetic variation at the melanocortin-1 receptor (<i>Mc1r</i>) gene is associated with melanin-based colour variation. Here, the <i>Mc1r</i> gene was sequenced from 12 jackal buzzard individuals displaying three distinct colour morphs (dark, intermediate and pale). A single nucleotide change was found, which although it resulted in an amino acid change, was shared by all jackal buzzards irrespective of colour morph. Although the <i>Mc1r</i> has played an important role in colour polymorphism in other species, in this study no association between <i>Mc1r</i> genotype and plumage polymorphism in jackal buzzards was found.