cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5285/10d3e3640f004c578403419aac167d82
title: CRU TS4.03: Climatic Research Unit (CRU) Time-Series (TS) version 4.03 of high-resolution gridded data of month-by-month variation in climate (Jan. 1901- Dec. 2018)

description: The gridded Climatic Research Unit (CRU) Time-series (TS) data version 4.03 data are month-by-month variations in climate over the period 1901-2018, provided on high-resolution (0.5x0.5 degree) grids, produced by CRU at the University of East Anglia. The CRU TS4.03 variables are cloud cover, diurnal temperature range, frost day frequency, potential evapotranspiration (PET), precipitation, daily mean temperature, monthly average daily maximum and minimum temperature, and vapour pressure for the period January 1901 - December 2018. The CRU TS4.03 data were produced using angular-distance weighting (ADW) interpolation. All version 4 releases used triangulation routines in IDL. Please see the release notes for full details of this version update. The CRU TS4.03 data are monthly gridded fields based on monthly observational data calculated from daily or sub-daily data by National Meteorological Services and other external agents. The ASCII and NetCDF data files both contain monthly mean values for the various parameters. The NetCDF versions contain an additional integer variable, ’stn’, which provides, for each datum in the main variable, a count (between 0 and 8) of the number of stations used in that interpolation. The missing value code for 'stn' is -999. All CRU TS output files are actual values - NOT anomalies.
DOI: 10.5439/2229846
title: Leipzig University W-Band Cloud Radar, Gothic (Colorado), SAIL Campaign Second Winter (15.11.2022 - 05.06.2023)

description: The instrument is a polarimetric W-Band <i>simultaneous transmission</i> simultaneous <i>reception<strong> </strong>(STSR)<strong> </strong></i>Doppler Cloud Radar manufactured by Radiometer Physics GmbH (RPG, instrument type RPG-FMCW-94-DP). It was deployed about 500m away from the ARM M1 facility in Gothic (CO) near the Ore House between Nov 15, 2022 and Jun 5, 2023 at an altitude of 2913 m. The Doppler cloud radar was mounted on a prototype of a cold temperature scanner manufactured by RPG. The dataset contains common radar variables like equivalent radar reflectivity factor, mean Doppler velocity, Doppler spectrum width as well as common polarimetric radar variables like differential phase shift (PhiDP), specific differential phase shift (KDP), correlation coefficient (RHV) and differential reflectivity (ZDR). Between Nov 15, 2022, and Feb 7, 2023 the radar was operated at 40° constant elevation and 151° azimuth (towards the KAZR at the AMF1). Between Feb 7 and Mar 15, 2023 the following scan cycle was repeated in 15min intervals: zenith pointing measurements, RHI scans from 0° to 90° and 90° to 0° elevation at 151° azimuth, constant elevation measurements at 40° elevation and 151° azimuth and PPI scans at 85° elevation for wind retrievals (one PPI per hour). Between Mar 15 18:18 UTC and Apr 8, 2023 11:04 UTC, the scanner was stuck at 72° elevation, which resulted in corrupted files for this period. For that period, the files containing data are uploaded but should be treated with care. Between Apr 8 and Apr 14, 2023 the scanning pattern described above was performed again. Afterwards, except for May 17 and May 18, 2023 where scanning patterns as described above were performed, measurements continued at 40° elevation and 151° azimuth until May 22, 2023 09:00 UTC. The scanning pattern was then started again, but without hourly PPI measurements until May 31, 2023. Between May 31 and Jun 5, 2023 solely zenith-pointing observations were performed. The data provided here are the RPG Level 1 (L1) files, Doppler spectra Level 0 (L0) files are available upon request.
DOI: 10.5439/2278627
title: VISSS Raw data from SAIL at Gothic from November 2022 to June 2023

description: A Video in situ Snowfall Sensor (VISSS) records shadow images of precipitating hydrometeors from two perspective at a 90 degree angle with a frequency of 140 Hz. From this, hydrometeor properties such as particle size, shape, complexity, degree of riming, and fall velocity can be derived. The VISSS was set up next to the ARM mobile facility during the SAIL project located in the East River Watershed near Crested Butte, Colorado from November 2022 to June 2023. The deployment was funded by the CORSIPP project (Characterization of orography-influenced riming and secondary ice production and their effects on precipitation rates using radar polarimetry and Doppler spectra) funded by the German Research Foundation (DFG). More information about the VISSS can be found in Maahn et al. 2023 (https://dx.doi.org/10.5194/egusphere-2023-655 )
DOI: 10.5517/ccvr11n
title: CCDC 796701: Experimental Crystal Structure Determination

description: Related Article: P.G.Jones|2010|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5523/bris.25wfy0f9ukoge2gs7a5mqpq2j7
title: FABDEM V1-0

description: FABDEM (Forest And Buildings removed Copernicus DEM) is a global elevation map that removes building and tree height biases from the Copernicus GLO 30 Digital Elevation Model (DEM). The data is available at 1 arc second grid spacing (approximately 30m at the equator) for the globe. The FABDEM dataset is licensed under a Creative Commons "CC BY-NC-SA 4.0" license. For commercial use queries, please contact fabdem@fathom.global This dataset is published in support of the paper "A 30 m global map of elevation with forests and buildings removed" published by IOP in Environmental Research Letters at https://dx.doi.org/10.1088/1748-9326/ac4d4f. *UPDATE 14/03/2022* - Tile N00E011_FABDEM_V1-0.tif was corrupted and has now been replaced. This has been reflected in the geotiff tags with the following text "NOTE=This file is a replacement for originally corrupted file for tile N00E011" -mo "UPDATED=2022-02-23"" *UPDATE 18/01/2023* - A new version of this dataset is available as FABDEM V1-2 at https://doi.org/10.5523/bris.s5hqmjcdj8yo2ibzi9b4ew3sn
DOI: 10.57967/hf/3771
title: LakeBeD-US-CSE
DOI: 10.15468/dl.p7sg3e
title: Occurrence Download

description: A dataset containing 833 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Polygonatum cyrtonema Hua"
 ]
}

 The dataset includes 833 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002731-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u744pg
title: Occurrence Download

description: A dataset containing 75 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chrysosplenium valdivicum Hook."
 ]
}

 The dataset includes 75 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002733-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7bh9cu
title: Occurrence Download

description: A dataset containing 879 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Anadendrum Schott"
 ]
}

 The dataset includes 879 records from 43 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002734-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jf6vdf
title: Occurrence Download

description: A dataset containing 83 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Specimen)",
 "Country is one of (Spain, Portugal)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Alnus incana (L.) Moench"
 ]
}

 The dataset includes 83 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002736-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6344tv
title: Occurrence Download

description: A dataset containing 70 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Acacia mangium Willd.",
 "Country is French Guiana",
 "Year is greater than or equal to 1500"
 ]
}

 The dataset includes 70 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002735-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14849522
title: Dataset for "Chewing behavior and bolus particle size of rice influence gastrointestinal carbohydrate digestion and microbiome metabolism in vitro"
DOI: 10.5281/zenodo.14849523
title: Dataset for "Chewing behavior and bolus particle size of rice influence gastrointestinal carbohydrate digestion and microbiome metabolism in vitro"
DOI: 10.17031/67b2f825d6e51
title: CPR Data request - PelagicFish - CEFAS - 17/02/2025

description: "All CPR samples.
From January 1958 to December 2021.
From 48 to 62 North, and -15.5 to 10 East.
Fish eggs (CPR ID = 90), Fish larvae (CPR ID = 91), and Anchovy eggs (CPR ID = 10753).
See guidelines in the archive."
DOI: 10.6084/m9.figshare.28189040
title: Manta-setting2-ConsL

description: Manta-setting2-ConsL
DOI: 10.21227/mwy5-es75
title: SMP(System Marginal Price)

description: This dataset contains South Korea's Jeju Island SMP (System Marginal Price) information for 2023. The data is organized chronologically, providing hourly SMP values for each day of the year. SMP represents the marginal cost of generating electricity and is a crucial factor in determining electricity prices. For Jeju Island, which has a separate power grid from mainland Korea, this data reflects local supply and demand dynamics, including the impact of renewable energy sources. The dataset offers valuable insights for energy market analysts, policymakers, and researchers studying electricity pricing patterns, grid management, and the integration of renewable energy in isolated power systems. It can be used for various analyses, including price forecasting, demand response strategies, and energy policy evaluations specific to Jeju Island's unique energy landscape.
DOI: 10.15468/dl.pu3j4m
title: Occurrence Download

description: A dataset containing 833 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Manis pentadactyla Linnaeus, 1758"
 ]
}

 The dataset includes 833 records from 69 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002739-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zbfx6b
title: Occurrence Download

description: A dataset containing 623 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Chrysosplenium wrightii Franch. & Sav."
 ]
}

 The dataset includes 623 records from 45 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002740-250214102907787/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28218789
title: Efficacy and safety of triple hormone receptor agonist retatrutide for the management of obesity: a systematic review and meta-analysis

description: Retatrutide is a novel triple hormone receptor agonist which has shown great promise in tackling obesity in preliminary trials. We did this systematic review and meta-analysis to pool the results of all available trials and ascertain its safety and efficacy in the treatment of obesity. A literature search was conducted in PubMed, Cochrane Central and Embase using appropriate search terms and randomized control trials (RCTs) were identified which reported the safety and efficacy of retatrutide. Data was pooled using mean differences for continuous variables and risk ratios for the safety profile in RStudio. After the initial search four RCTs were included in the analysis which compared the safety and efficacy of retatrutide versus placebo. Retatrutide showed a dose dependent relationship with the 12 mg dose causing the maximum reductions across all the outcomes considered. The safety profile of retatrutide was found to be comparable to the control group. In conclusion our analysis found retatrutide to be clinically and statistically better than placebo in the various studies outcomes. We eagerly await the conduction of further trials for more robust and substantial results. www.crd.york.ac.uk/prospero identifier is CRD42024566153.
DOI: 10.6084/m9.figshare.28428713
title: Genetic screening of the RNA-binding protein RBM24 and its binding sites in the <i>SOX2</i> 3’ untranslated region in a cohort of 50 patients with micro-anophthalmia

description: Microphthalmia and anophthalmia (M/A) are rare congenital eye anomalies with a birth prevalence of up to 1 in 10,000 births. The etiology of M/A can involve environmental and/or genetic factors, with a genetic origin identified in approximately 50% of cases through analysis of key genes. The transcription factor <i>SOX2</i> is the most commonly implicated gene, accounting for around 15% of M/A cases. Recent studies have shown that the RNA-binding protein Rbm24 post-transcriptionally regulates <i>Sox2</i> expression in mice and zebrafish, with <i>Rbm24</i> null models exhibiting eye phenotypes in both species. Rbm24 can bind to <i>Sox2</i> mRNA <i>via</i> three AU-Rich elements (AREs) located in its 3’ untranslated region (UTR). In this study, we aimed to determine whether pathogenic variants within <i>RBM24</i> or the <i>SOX2</i> 3’UTR AREs were present in a cohort of 50 individuals with M/A with no identified genetic cause for their condition. Despite the ocular defects observed in animal models, we did not detect any variant of interest in these candidate regions in our cohort. Although we cannot exclude the involvement of pathogenic variations in <i>RBM24</i> or the <i>SOX2</i> 3’UTR AREs in ocular developmental defects, our study shows that they are unlikely to represent a frequent cause of M/A.
DOI: 10.6084/m9.figshare.28428713.v1
title: Genetic screening of the RNA-binding protein RBM24 and its binding sites in the <i>SOX2</i> 3’ untranslated region in a cohort of 50 patients with micro-anophthalmia

description: Microphthalmia and anophthalmia (M/A) are rare congenital eye anomalies with a birth prevalence of up to 1 in 10,000 births. The etiology of M/A can involve environmental and/or genetic factors, with a genetic origin identified in approximately 50% of cases through analysis of key genes. The transcription factor <i>SOX2</i> is the most commonly implicated gene, accounting for around 15% of M/A cases. Recent studies have shown that the RNA-binding protein Rbm24 post-transcriptionally regulates <i>Sox2</i> expression in mice and zebrafish, with <i>Rbm24</i> null models exhibiting eye phenotypes in both species. Rbm24 can bind to <i>Sox2</i> mRNA <i>via</i> three AU-Rich elements (AREs) located in its 3’ untranslated region (UTR). In this study, we aimed to determine whether pathogenic variants within <i>RBM24</i> or the <i>SOX2</i> 3’UTR AREs were present in a cohort of 50 individuals with M/A with no identified genetic cause for their condition. Despite the ocular defects observed in animal models, we did not detect any variant of interest in these candidate regions in our cohort. Although we cannot exclude the involvement of pathogenic variations in <i>RBM24</i> or the <i>SOX2</i> 3’UTR AREs in ocular developmental defects, our study shows that they are unlikely to represent a frequent cause of M/A.
DOI: 10.6084/m9.figshare.27720959
title: Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake

description: Transmembrane transport remains a significant challenge for nucleic acid vaccine vectors. Promoting the ability of immune cells, such as macrophages, to capture foreign stimuli is also an effective approach to improving cross-presentation. In addition, polyethyleneimine (PEI) has gained attention in the field of nucleic acid vaccine carriers due to its excellent gene transfection efficiency and unique proton buffering effect. However, although high molecular weight PEI exhibits high efficiency, its high-density positive charges make it highly toxic, which limits its application. In this study, mannose/stearyl chloride functionalized polyethylenimine (SA-Man-PEI) was prepared by functionalizing PEI (molecular weight of 25 kDa) with mannose with immunomodulatory and phagocyte targeting effects, and an alkyl hydrophobic chain segment, which could easily promote cell uptake. Moreover, the functionalized-PEI retains a strong proton buffering effect, which helps the carrier escape from the lysosome. The particle sizes of the composite particles formed by SA-Man-PEI and ovalbumin (OVA) were below 200 nm, with good storage stability at both 4 °C and 37 °C. At a drug concentration of 2 μg/mL, the cell survival rate of functionalized-PEI was 19.2% higher than that of unfunctionalized PEI. In vitro macrophage endocytosis experiments showed that SA-Man-PEI could significantly enhance the macrophage uptake of composite particles, compared to unfunctionalized PEI or single-functionalized PEI. This study offers a new approach for developing PEI as a nucleic acid vaccine carrier, which could simultaneously enhance cell targeting and promote cell uptake.
DOI: 10.6084/m9.figshare.27720959.v1
title: Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake

description: Transmembrane transport remains a significant challenge for nucleic acid vaccine vectors. Promoting the ability of immune cells, such as macrophages, to capture foreign stimuli is also an effective approach to improving cross-presentation. In addition, polyethyleneimine (PEI) has gained attention in the field of nucleic acid vaccine carriers due to its excellent gene transfection efficiency and unique proton buffering effect. However, although high molecular weight PEI exhibits high efficiency, its high-density positive charges make it highly toxic, which limits its application. In this study, mannose/stearyl chloride functionalized polyethylenimine (SA-Man-PEI) was prepared by functionalizing PEI (molecular weight of 25 kDa) with mannose with immunomodulatory and phagocyte targeting effects, and an alkyl hydrophobic chain segment, which could easily promote cell uptake. Moreover, the functionalized-PEI retains a strong proton buffering effect, which helps the carrier escape from the lysosome. The particle sizes of the composite particles formed by SA-Man-PEI and ovalbumin (OVA) were below 200 nm, with good storage stability at both 4 °C and 37 °C. At a drug concentration of 2 μg/mL, the cell survival rate of functionalized-PEI was 19.2% higher than that of unfunctionalized PEI. In vitro macrophage endocytosis experiments showed that SA-Man-PEI could significantly enhance the macrophage uptake of composite particles, compared to unfunctionalized PEI or single-functionalized PEI. This study offers a new approach for developing PEI as a nucleic acid vaccine carrier, which could simultaneously enhance cell targeting and promote cell uptake.
DOI: 10.34740/kaggle/dsv/10771721
title: cypto_data
DOI: 10.6084/m9.figshare.27263642
title: Drug retention after intradiscal administration

description: Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics. Release and retention of an inactive hydrophilic fluorine-19 labeled peptide (<sup>19</sup>F-P) as model for regenerative peptides was studied in a whole IVD culture model by measuring the <sup>19</sup>F-NMR (nuclear magnetic resonance) signal in culture media and IVD tissue extracts. In another set-up, noninvasive near-infrared imaging was used to visualize IR-780, as hydrophobic small molecular drug model, retention upon injection into healthy and degenerative caudal IVDs in a rat model of disk degeneration. Furthermore, IR-780-loaded degradable polyester amide microspheres (PEAM) were injected into healthy and needle pricked degenerative IVDs, subcutaneously, and in knee joints with and without surgically-induced osteoarthritis (OA). Most <sup>19</sup>F-P was released from the IVD after 7 days. IR-780 signal intensity declined over a 14-week period after bolus injection, without a difference between healthy and degenerative disks. IR-780 signal declined faster in the skin and knee joints compared to the IVDs. IR-780 delivery by PEAMs enhanced disk retention beyond 16 weeks. Moreover, in degenerated IVDs the IR-780 signal was higher over time than in healthy IVDs while no difference between OA and healthy joints was noted. We conclude that the clearance of peptides and hydrophobic small molecules from the IVD is relatively fast. These results illustrate that development of controlled release formulations should take into account the target anatomical location and local (patho)biology. Tissue degeneration alters molecule retention in tissues with a low fluid clearanceExtrapolating retention between different anatomical locations is not recommendedDrug delivery platforms should be customized to anatomical locationDrug delivery platforms should be customized to existing pathophysiology Tissue degeneration alters molecule retention in tissues with a low fluid clearance Extrapolating retention between different anatomical locations is not recommended Drug delivery platforms should be customized to anatomical location Drug delivery platforms should be customized to existing pathophysiology