cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3535/z6b-sar-vyp
title: Lepidoptera Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/444-nq9-aks
title: Danainae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/6pw-kmd-r53
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/bjz-gtz-yvz
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/32l-q82-y55
title: Lepidoptera Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dn6-33s-3qf
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/dwz-92n-fwq
title: Lepidoptera Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/les-34r-x8d
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/36l-y8a-dzn
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/jfh-ppg-3ts
title: Spilomelinae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rgp-6fl-7d5
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g50-zzb-17c
title: Lepidoptera Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/h89-day-kqs
title: Thyatirinae Smith, 1893

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lc7-mmf-wcm
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/651-y3d-cfn
title: Danainae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8b4-nx6-dfz
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8kj-hz7-5tj
title: Lepidoptera Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/n2x-7za-z5a
title: Danainae

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4fs-mhs-4rp
title: Arctiinae Leach, 1815

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fvx-9aa-1nq
title: Lepidoptera Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.akbf9q
title: Occurrence Download

description: A dataset containing 16869 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Clinopodium grandiflorum"
 ]
}

 The dataset includes 16869 records from 226 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010632-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.13290722
title: Additional file 1 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 1: Table S1A-D. Characteristics of the participating studies in the main meta-analyses.
DOI: 10.6084/m9.figshare.13290743
title: Additional file 8 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 8: Table S6A-C. Associations between DNA methylation and BMI in children, excluding studies with &gt; 30% overweight or obesity. Results for CpGs with p-values &lt; 1x10-4 are shown.
DOI: 10.6084/m9.figshare.20626433.v1
title: Additional file 4 of Proteomics-based evaluation of the mechanism underlying vascular injury via DNA interstrand crosslinks, glutathione perturbation, mitogen-activated protein kinase, and Wnt and ErbB signaling pathways induced by crotonaldehyde

description: Additional file 4: Table S4. Differentially expressed proteins after treatment with CRA.
DOI: 10.6084/m9.figshare.13290746
title: Additional file 9 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 9: Table S7A-D. Associations between DNA methylation and BMI in childhood and adolescence, excluding studies with participants of non-European ancestry, those with a high percentage (&gt;30%) of children with overweight/obesity, and, finally, studies with a population for this analysis that was selected based on a particular exposure or outcome.
DOI: 10.6084/m9.figshare.13290737.v1
title: Additional file 6 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 6: Table S4. CpGs within a window of +/- 5kb from the Bonferroni- and FDR-significant CpGs in each model.
DOI: 10.6084/m9.figshare.13290737
title: Additional file 6 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 6: Table S4. CpGs within a window of +/- 5kb from the Bonferroni- and FDR-significant CpGs in each model.
DOI: 10.6084/m9.figshare.6999416.v1
title: Additional file 2: of Welding fume exposure is associated with inflammation: a global metabolomics profiling study

description: Table S1. Statistical summary of the 693 metabolites. Table S2.Sensitivity analysis that only keep the male workers. Table S3. MSEA analysis for disease-associated metabolite sets (blood). (XLSX 318 kb)
DOI: 10.6084/m9.figshare.13290743.v1
title: Additional file 8 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

description: Additional file 8: Table S6A-C. Associations between DNA methylation and BMI in children, excluding studies with &gt; 30% overweight or obesity. Results for CpGs with p-values &lt; 1x10-4 are shown.
DOI: 10.6084/m9.figshare.6484646
title: ChIP

description: To
verify the direct activation of miR-92b from SP1, we performed ChIP assays with
PCI-4A cells to respectively affirm the binding reaction of the 5 binding sites
in miR-92b promoter region. The
binding of each predicted sites were evaluated with 7 parallel groups: (A)
experiment group: immunoprecipitated with SP1 antibody and amplified with
targeted primers; (B) RT-Input1: without immunoprecipitation and amplified with
targeted primers; (C) negative control group: immunoprecipitated with host IgG
and amplified with targeted primers; (D) PCR negative control: using ddH<sub>2</sub>O
as template and amplified with targeted primers; (E) positive control group:
immunoprecipitated with RNA polymerase II and amplified with GAPDH primers; (F)
RT-Input2: without immunoprecipitation and amplified with GAPDH primers; (G)
WB-Input: western bloting SP1 protein expression in total DNA-protein
crosslink.The results indicated that there was a significant
enrichment of SP1 protein at the first 3 binding sites, whereas no obvious
reaction was found in site 4 and site 5.
DOI: 10.6084/m9.figshare.23786454
title: Statistical Modeling of the Effectiveness of Preventive Maintenance for Repairable Systems

description: Preventive maintenance (PM) is commonly adopted in practice to improve a system’s health condition and reduce the risk of unexpected failures. When a PM action is poorly performed, however, it is likely to have adverse effects on system reliability. We observe this phenomenon when evaluating the effectiveness of a PM program for a fleet of service vehicles based on their four-year operating data. This phenomenon is also commonly reported in the maintenance of vehicles and aircraft. Motivated by this observation, we propose a statistical model for repairable systems by taking potential PM adverse effects into account. In the formulation, the baseline failure process without PM effects is modeled by a nonhomogeneous Poisson process. When a PM action is performed, its effect on the failure process is modeled as a multiplicative random effect on the system rate of occurrence of failures. Statistical inference under the proposed model is discussed, and we further develop goodness-of-fit test procedures to validate the adequacy of this model. The above-mentioned service vehicle operating data are used to demonstrate the proposed methods.
DOI: 10.6084/m9.figshare.23786454.v2
title: Statistical Modeling of the Effectiveness of Preventive Maintenance for Repairable Systems

description: Preventive maintenance (PM) is commonly adopted in practice to improve a system’s health condition and reduce the risk of unexpected failures. When a PM action is poorly performed, however, it is likely to have adverse effects on system reliability. We observe this phenomenon when evaluating the effectiveness of a PM program for a fleet of service vehicles based on their four-year operating data. This phenomenon is also commonly reported in the maintenance of vehicles and aircraft. Motivated by this observation, we propose a statistical model for repairable systems by taking potential PM adverse effects into account. In the formulation, the baseline failure process without PM effects is modeled by a nonhomogeneous Poisson process. When a PM action is performed, its effect on the failure process is modeled as a multiplicative random effect on the system rate of occurrence of failures. Statistical inference under the proposed model is discussed, and we further develop goodness-of-fit test procedures to validate the adequacy of this model. The above-mentioned service vehicle operating data are used to demonstrate the proposed methods.
DOI: 10.6084/m9.figshare.16970740
title: Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration and angiogenesis of keratinocytes by modulating heparanase stability

description: Wound healing is related to proliferation, migration and angiogenesis of keratinocytes. Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is an important N6-methyladenosine (m6A) reader, which is involved in multiple processes, including wound healing. However, the function and mechanism of IGF2BP2 in keratinocyte processes are largely uncertain. In the present study, expression levels of IGF2BP2 and heparanase (HPSE) were detected by quantitative reverse transcription polymerase chain reaction and western blotting assays. Cell proliferation was investigated with cell counting kit-8 analysis. Cell migration was determined through wound healing assay. Angiogenesis was measured by tube formation assay and vascular endothelial growth factor (VEGF) level using enzyme linked immunosorbent assay. The interaction between IGF2BP2 and HPSE was analyzed by RNA immunoprecipitation, pull-down and luciferase reporter analyses. The results showed that IGF2BP2 expression was enhanced in wound healing. IGF2BP2 downregulation constrained HaCaT cell proliferation, migration and angiogenesis. IGF2BP2 knockdown decreased HPSE expression. IGF2BP2 could regulate HPSE stability by binding with 3ʹ untranslated region (UTR) of HPSE. HPSE upregulation attenuated silencing IGF2BP2-mediated suppression of proliferation, migration and angiogenesis. As a conclusion, IGF2BP2 knockdown repressed proliferation, migration and angiogenesis of HaCaT cells by decreasing HPSE stability.
DOI: 10.6084/m9.figshare.16970741
title: MicroRNA-223-3p is involved in fracture healing by regulating fibroblast growth factor receptor 2

description: MicroRNAs (miRNAs) are powerful modulators of fracture healing. The research explored the level of serum miR-223-3p in fracture patients and its potential mechanism in fracture healing. In the study, miR-223-3p levels in 42 patients with intra-articular fracture and 40 patients with hand fracture were detected by real-time fluorescence quantitative PCR reaction (qRT-PCR). Subsequently, osteoblasts MC3T3-E1 was transfected with miR-223-3p mimic or inhibitor, and cell function was detected by Cell counting kit (CCK-8) assay and flow cytometry. Dual-luciferase reporter assay verified the regulation mechanism of miR-223-3p and its target genes. We found that miR-223-3p was significantly elevated over time in patients with intra-articular fracture and hand fracture compared with healthy individuals. Moreover, increased miR-223-3p significantly reduced cell viability and promoted cell apoptosis. The fibroblast growth factor receptor 2 (FGFR2) was the target of miR-223-3p. Serum FGFR2 was significantly decreased in patients, which was contrary to the expression of miR-223-3p. Moreover, FGFR2 levels in cells were negatively regulated by miR-223-3p. Finally, si-FGFR2 significantly reversed the promotion of miR-223-3p inhibitor on cell viability and the inhibition of cell apoptosis. Our research suggested that miR-223-3p is highly expressed in fracture patients, and regulates osteoblast cell viability and apoptosis by targeting FGFR2. This may be a valuable target for fracture healing therapy and provide a new perspective for its treatment.
DOI: 10.6084/m9.figshare.16970744
title: Network pharmacology and experimental validation to explore the molecular mechanisms of Bushen Huoxue for the treatment of premature ovarian insufficiency

description: Bushen Huoxue (BSHX) has been applied in clinical traditional Chinese medicine treatment, and has definitive clinical efficacy in the treatment of Premature Ovarian Insufficiency (POI) in China. However, little is known of the underlying mechanism of BSHX. The purpose of this paper is to study the pharmacological mechanisms of BSHX acting on POI based on a pharmacology and experimental validation. The pharmacological database of chinese medicine system and analysis platform (TCMSP) were used to search the effective active ingredients and potential action targets of BSHX. Drugbank, Online Mendelian Inheritance in Man (OMIM), Genecards, and Disgenet databases were used to obtain relevant targets of POI. Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and the visual network of protein-protein interaction network were constructed by FunRich3.1. Pymol software, and Auto Dock tools 1.5.6 were used for molecular docking. Murine model of POI was used to further investigate the mechanism of BSHX against on POI. Finally, 127 active compounds were collected from TCMSP database, and 215 active targets were identified. There were 1366 targets related to POI and 99 targets of BSHX for the treatment of POI. Quercetin, kaempferol, and stigmasterol were recognized as the most effective compounds corresponding to targets. The top three genes according to degree value are TP53, Akt1, and VEGFA. Further, the results of GO and KEGG enrichment analysis revealed that those core targets were mainly enriched on TRAIL and TGF-β receptor signaling. The results of molecular docking showed that stigmasterol had good binding ability to Akt1. Moreover, experimental validation suggests that BSHX significantly Increased the expression of TGF-β1 and Smad2/3, regulating the release of serum sex hormones, which include Follicular stimulating hormone (FSH), Estradiol (E2), and Antimullerin hormone (AMH). BSHX treats POI by regulating TGF-β1 and Smad2/3 signaling pathways; Quercetin, kaempferol, and stigmasterol were the most effective compounds in BSHX.
DOI: 10.6084/m9.figshare.3863580
title: In silico screening, molecular docking, and molecular dynamics studies of SNP-derived human P5CR mutants

description: Pyrroline-5-carboxylate reductase (P5CR) encoded by <i>PYCR1</i> gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor. In this study, we used in silico approaches to examine the role of nonsynonymous single-nucleotide polymorphisms in the <i>PYCR1</i> gene and their putative functions in the pathogenesis of Cutis Laxa. Among the 348 identified SNPs, 15 were predicted to be potentially damaging by both SIFT and PolyPhen tools; of them two SNP‐derived mutations, R119G and G206W, have been previously reported to correlate with Cutis Laxa. These two mutations were therefore selected to be mapped to the wild‐type (WT) P5CR structure for further structural and functional analyses. The results of comparative computational analyses using I-Mutant and Autodock reveal reductions in both stability and cofactor binding affinity of these two mutants. Comparative molecular dynamics (MD) simulations were performed to evaluate the changes in dynamic properties of P5CR upon mutations. The results reveal that the two mutations enhance the rigidity of P5CR structure, especially that of cofactor binding site, which could result in decreased kinetics of cofactor entrance and egress. Comparison between the structural properties of the WT and mutants during MD simulations shows that the enhanced rigidity of mutants results most likely from the increased number of inter‐atomic interactions and the decreased number of dynamic hydrogen bonds. Our study provides novel insight into the deleterious effects of the R119G and G206W mutations on P5CR, and sheds light on the mechanisms by which these mutations mediate Cutis Laxa.
DOI: 10.6084/m9.figshare.3863580.v1
title: In silico screening, molecular docking, and molecular dynamics studies of SNP-derived human P5CR mutants

description: Pyrroline-5-carboxylate reductase (P5CR) encoded by <i>PYCR1</i> gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor. In this study, we used in silico approaches to examine the role of nonsynonymous single-nucleotide polymorphisms in the <i>PYCR1</i> gene and their putative functions in the pathogenesis of Cutis Laxa. Among the 348 identified SNPs, 15 were predicted to be potentially damaging by both SIFT and PolyPhen tools; of them two SNP‐derived mutations, R119G and G206W, have been previously reported to correlate with Cutis Laxa. These two mutations were therefore selected to be mapped to the wild‐type (WT) P5CR structure for further structural and functional analyses. The results of comparative computational analyses using I-Mutant and Autodock reveal reductions in both stability and cofactor binding affinity of these two mutants. Comparative molecular dynamics (MD) simulations were performed to evaluate the changes in dynamic properties of P5CR upon mutations. The results reveal that the two mutations enhance the rigidity of P5CR structure, especially that of cofactor binding site, which could result in decreased kinetics of cofactor entrance and egress. Comparison between the structural properties of the WT and mutants during MD simulations shows that the enhanced rigidity of mutants results most likely from the increased number of inter‐atomic interactions and the decreased number of dynamic hydrogen bonds. Our study provides novel insight into the deleterious effects of the R119G and G206W mutations on P5CR, and sheds light on the mechanisms by which these mutations mediate Cutis Laxa.
DOI: 10.6084/m9.figshare.6999371
title: MOESM1 of Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

description: Additional file 1: Table S1. Additional table.
DOI: 10.6084/m9.figshare.8057999.v1
title: Additional file 11: of Genetic architecture of grain yield in bread wheat based on genome-wide association studies

description: Table S7. Phenotypic data in each environment and BLUE value for grain yield and related traits in the diverse panel. GY, grain yield; SN, spike number per square meter; KNS, kernel number per spike; TKW, thousand-kernel weight; KL, kernel length; KW, kernel width; SL, spike length; SDW, spike dry weight; HD, heading date; PH, plant height; UIL, uppermost internode length; FLL, flag leaf length; FLW, flag leaf width. (XLSX 151 kb)
DOI: 10.6084/m9.figshare.6485174
title: Immunohistochemistry

description: enograft
tumor from in vivo experiment was havested and fixed in 4% paraformaldehyde.
Paraffin-embedded sections were used for haematoxylin-eosin (HE) staining and
immunohistochemistry assays. For immunohistochemical staining, the sections
were incubated with first antibody of SP1 (1:200, 9389, Cell Signaling
Technology) or CCR7 (1:200, ab32527, Abcam) at 4℃ overnight. Then incubated in biotinylated Goat anti rabbit IgG at 37℃ for 30min, following by herseradish peroxidase (HRP) labeled avidin
incubation. After visualization with diaminobenzidine (DAB), the sections were
counterstained with hematoxylin and observed under 400x. Negative controls were
obtained by omitting the primary antibodies. The expression of SP1 and CCR7
protein was semi-quantitatively measured by using Image Pro Plus 6.0 (Media
Cybernetics, Inc., MD, USA).
DOI: 10.6084/m9.figshare.19582294
title: Additional file 2 of FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA

description: Additional file 2. GO enrichment of DEmRNAs.
DOI: 10.6084/m9.figshare.19582312
title: Additional file 8 of FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA

description: Additional file 8. Crucial lncRNAs in blue module associated with AF based on WGCNA.
DOI: 10.6084/m9.figshare.19582309
title: Additional file 7 of FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA

description: Additional file 7. The association between lncRNAs and miRNAs, miRNA and mRNAs in the ceRNA network.
DOI: 10.6084/m9.figshare.19582255
title: Additional file 2 of Distributions and trends of the global burden of COPD attributable to risk factors by SDI, age, and sex from 1990 to 2019: a systematic analysis of GBD 2019 data

description: Additional file 2: Figure S1. Age-standardized rate of SEV of 8 main risk factors by SDI quintiles and sex from 1990 to 2019. Figure S2. Contributions of 8 main risk factors to the PAF of age-standardized death due to chronic obstructive pulmonary disease by different SDI quintiles and sexes from 1990 to 2019. Figure S3. Contributions of 8 main risk factors to the PAF of age-standardized YLD due to chronic obstructive pulmonary disease by different SDI quintiles and sexes from 1990 to 2019. Figure S4. Contributions of 8 main risk factors to the PAF of age-standardized YLL due to chronic obstructive pulmonary disease by different SDI quintiles and sexes from 1990 to 2019. Figure S5. The global burden of COPD attributable to occupational particles over the past 30 years. Figure S6. The global burden of COPD attributable to secondhand smoke over the past 30 years. Figure S7. The global burden of COPD attributable to ambient ozone pollution over the past 30 years. Figure S8. The global burden of COPD attributable to high temperature over the past 30 years. Figure S9. The global burden of COPD attributable to low temperature over the past 30 years.
DOI: 10.6084/m9.figshare.6999371.v1
title: MOESM1 of Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

description: Additional file 1: Table S1. Additional table.
DOI: 10.6084/m9.figshare.19582291.v1
title: Additional file 1 of FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA

description: Additional file 1. Differentially expressed lncRNAs in AF samples compared with SR samples.
DOI: 10.6084/m9.figshare.7523693.v1
title: MOESM1 of Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma

description: Additional file 1. Clinical data of LUAD from TCGA cohort.