cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21856332
title: Systemic Immune Inflammation Index is a Novel Marker in Predicting the Presence and Severity of Isolated Coronary Artery Ectasia

description: Abstract Background The underlying pathology of isolated coronary artery ectasia (CE) has not been fully elucidated. Objective We aimed to examine the relationship between the systemic immune inflammation index (Sıı), which corresponds to the multiplying of the neutrophil-to-lymphocyte ratio (NLR) and the platelet counts, and isolated CE. Method The retrospective study population included 200 patients with isolated CE, 200 consecutive with obstructive coronary artery disease, and 200 consecutive with a normal coronary artery angiogram. A 2-sided p-value of &lt;0.05 was considered significant. Results Sıı, NLR, platelet-to-lymphocyte ratio (PLR), and monocyte-to-high density lipoprotein cholesterol ratio (MHR) were significantly higher in the CE group compared with the other groups (all p&lt;0.001). In multivariate analysis, Sıı (p&lt;0.001, OR = 1.005, 95% CI =1.004-1.005) was found to be an independent predictor of isolated CE. In Receiver Operating Characteristic curve analysis, Sıı had a higher Area Under the Curve than NLR, PLR, and MHR. Sıı value of &gt;517.35 has 79% sensitivity, 76% specificity for the prediction of the CE [AUC: 0.832, (p&lt;0.001)]. Sıı had a significant correlation with the number of ectatic coronary arteries and Markis classification (r:0.214 p=0.002; r:-0.195, p=0.006, respectively). Conclusion To the best of our knowledge, this is the first study that Sıı was significantly associated with isolated CE presence and anatomical severity.
DOI: 10.6084/m9.figshare.21856332.v1
title: Systemic Immune Inflammation Index is a Novel Marker in Predicting the Presence and Severity of Isolated Coronary Artery Ectasia

description: Abstract Background The underlying pathology of isolated coronary artery ectasia (CE) has not been fully elucidated. Objective We aimed to examine the relationship between the systemic immune inflammation index (Sıı), which corresponds to the multiplying of the neutrophil-to-lymphocyte ratio (NLR) and the platelet counts, and isolated CE. Method The retrospective study population included 200 patients with isolated CE, 200 consecutive with obstructive coronary artery disease, and 200 consecutive with a normal coronary artery angiogram. A 2-sided p-value of &lt;0.05 was considered significant. Results Sıı, NLR, platelet-to-lymphocyte ratio (PLR), and monocyte-to-high density lipoprotein cholesterol ratio (MHR) were significantly higher in the CE group compared with the other groups (all p&lt;0.001). In multivariate analysis, Sıı (p&lt;0.001, OR = 1.005, 95% CI =1.004-1.005) was found to be an independent predictor of isolated CE. In Receiver Operating Characteristic curve analysis, Sıı had a higher Area Under the Curve than NLR, PLR, and MHR. Sıı value of &gt;517.35 has 79% sensitivity, 76% specificity for the prediction of the CE [AUC: 0.832, (p&lt;0.001)]. Sıı had a significant correlation with the number of ectatic coronary arteries and Markis classification (r:0.214 p=0.002; r:-0.195, p=0.006, respectively). Conclusion To the best of our knowledge, this is the first study that Sıı was significantly associated with isolated CE presence and anatomical severity.
DOI: 10.6084/m9.figshare.21856333
title: Productivity and analysis of morphological characters of experimental strawberry genotypes

description: ABSTRACT In the world the consumption of strawberries is very appreciated, both in natura or industrialized form. Brazilian production depends on the importation of strawberry seedlings from countries such as Spain, Chile and Argentina, which are cultivars improved in temperate climates and, consequently, not well adapted to the Brazilian tropical conditions. Thus, genetic breeding programs are essential for the generation of more adapted cultivars. The objective was to evaluate and characterize the performance of experimental strawberry genotypes. The statistical design adopted was in randomized blocks, with 12 treatments and 3 replications, the treatments consisting of seven experimental genotypes and five commercial cultivars. We evaluated the total production per plant (g/plant), average weight of fruits per plant (g/fruit), % of commercial fruits per plant, and morphological characterization. The experimental genotypes MFA443, MCA94, MDA23, MDA06 and MCA89 showed the highest strawberry yields per plant, respectively, 285 g, 254 g, 298 g, 295 g and 290 g, with emphasis on the genotype MFA12-443, which also presented the highest average weight of fruits (20.35 g) and percentage of commercial fruits (81%).
DOI: 10.6084/m9.figshare.21856333.v1
title: Productivity and analysis of morphological characters of experimental strawberry genotypes

description: ABSTRACT In the world the consumption of strawberries is very appreciated, both in natura or industrialized form. Brazilian production depends on the importation of strawberry seedlings from countries such as Spain, Chile and Argentina, which are cultivars improved in temperate climates and, consequently, not well adapted to the Brazilian tropical conditions. Thus, genetic breeding programs are essential for the generation of more adapted cultivars. The objective was to evaluate and characterize the performance of experimental strawberry genotypes. The statistical design adopted was in randomized blocks, with 12 treatments and 3 replications, the treatments consisting of seven experimental genotypes and five commercial cultivars. We evaluated the total production per plant (g/plant), average weight of fruits per plant (g/fruit), % of commercial fruits per plant, and morphological characterization. The experimental genotypes MFA443, MCA94, MDA23, MDA06 and MCA89 showed the highest strawberry yields per plant, respectively, 285 g, 254 g, 298 g, 295 g and 290 g, with emphasis on the genotype MFA12-443, which also presented the highest average weight of fruits (20.35 g) and percentage of commercial fruits (81%).
DOI: 10.6084/m9.figshare.21856336
title: Trends in the schooling of São Paulo elites in the 20th and 21st Centuries

description: ABSTRACT The objective of this article is to problematize questions about the attendance in basic education of four generations of the elite of São Paulo in the 20th and 21st centuries. This is the analysis of data collected in research Pensamento e Práticas de Cultura da Elite Paulistana1. Based on a questionnaire and interviews carried out between 2018 and 2019, the intention is to analyze the reasons for the choice and the representations about schools. The main hypothesis is based on Pierre Bourdieu’s relational theory of groups, among others, and its subjective and objective ways of building the dispositions of a habitus. To develop the argument, we will make a relational exercise between types of institutions frequented by the researched subjects and their children, remembering the categories of frameworks, time, modalities and cultural dispositions that emerge from them. Through aspects such as the image of establishments on institutional sites, date of foundation, pedagogical objectives, affiliations with international and religious projects, we have observed elements of such processes more closely. As a result, we can say that in addition to the existence of a close correspondence between school selections and family projects, always according to the time of belonging to the elites and sectors of the economy, there would be a tendency since the beginning of the last century for schools with links in the outside.
DOI: 10.6084/m9.figshare.21856336.v1
title: Trends in the schooling of São Paulo elites in the 20th and 21st Centuries

description: ABSTRACT The objective of this article is to problematize questions about the attendance in basic education of four generations of the elite of São Paulo in the 20th and 21st centuries. This is the analysis of data collected in research Pensamento e Práticas de Cultura da Elite Paulistana1. Based on a questionnaire and interviews carried out between 2018 and 2019, the intention is to analyze the reasons for the choice and the representations about schools. The main hypothesis is based on Pierre Bourdieu’s relational theory of groups, among others, and its subjective and objective ways of building the dispositions of a habitus. To develop the argument, we will make a relational exercise between types of institutions frequented by the researched subjects and their children, remembering the categories of frameworks, time, modalities and cultural dispositions that emerge from them. Through aspects such as the image of establishments on institutional sites, date of foundation, pedagogical objectives, affiliations with international and religious projects, we have observed elements of such processes more closely. As a result, we can say that in addition to the existence of a close correspondence between school selections and family projects, always according to the time of belonging to the elites and sectors of the economy, there would be a tendency since the beginning of the last century for schools with links in the outside.
DOI: 10.6084/m9.figshare.21856338
title: Hypoparathyroidism and Fahr’s syndrome: case series

description: Abstract Hypoparathyroidism (HP) is a rare metabolic disorder and causes hypocalcemia because parathyroid hormone secretion is inadequate to mobilize calcium from bone and reabsorb calcium from kidney and gut. Anterior neck surgery is the most common cause of acquired HP and autoimmune HP is the next most common form in adults. The duration, severity, and rate of development of hypocalcemia determine the clinical presentation. A variety of organs can be affected by calcification, more frequently kidneys, but also joints, eyes, skin, vasculature, and other organ systems and, although rarely seen, intracerebral calcifications. We report four cases of bilateral basal ganglia calcifications (BGC) also known as Fahr’s syndrome related to hypoparathyroidism. Fahr’s syndrome is characterized by bilateral symmetrical calcification of areas of the brain that control movements including basal ganglia, thalamus, and others; it is a rare inherited or sporadic neurological disorder with a prevalence of less than 1/1.000.000. Main symptoms related to bilateral BGC include extra-pyramidal and cerebellar disorders, cognitive impairment, epileptic seizures, and psychiatric changes. BGC has been established as a possible outcome of HP. Its prevalence, demonstrated in the HP cohorts, varied significantly from 12 up to 74%. Currently, computed tomography (CT) is the most valuable method for diagnosis. The treatment include symptomatic support and identification of causes, but there is no specific treatment limiting the progression of calcification in the basal ganglia. Especially in HP, an early treatment can prevent calcification and neurophysiological disorders.
DOI: 10.6084/m9.figshare.21856338.v1
title: Hypoparathyroidism and Fahr’s syndrome: case series

description: Abstract Hypoparathyroidism (HP) is a rare metabolic disorder and causes hypocalcemia because parathyroid hormone secretion is inadequate to mobilize calcium from bone and reabsorb calcium from kidney and gut. Anterior neck surgery is the most common cause of acquired HP and autoimmune HP is the next most common form in adults. The duration, severity, and rate of development of hypocalcemia determine the clinical presentation. A variety of organs can be affected by calcification, more frequently kidneys, but also joints, eyes, skin, vasculature, and other organ systems and, although rarely seen, intracerebral calcifications. We report four cases of bilateral basal ganglia calcifications (BGC) also known as Fahr’s syndrome related to hypoparathyroidism. Fahr’s syndrome is characterized by bilateral symmetrical calcification of areas of the brain that control movements including basal ganglia, thalamus, and others; it is a rare inherited or sporadic neurological disorder with a prevalence of less than 1/1.000.000. Main symptoms related to bilateral BGC include extra-pyramidal and cerebellar disorders, cognitive impairment, epileptic seizures, and psychiatric changes. BGC has been established as a possible outcome of HP. Its prevalence, demonstrated in the HP cohorts, varied significantly from 12 up to 74%. Currently, computed tomography (CT) is the most valuable method for diagnosis. The treatment include symptomatic support and identification of causes, but there is no specific treatment limiting the progression of calcification in the basal ganglia. Especially in HP, an early treatment can prevent calcification and neurophysiological disorders.
DOI: 10.6084/m9.figshare.21856339
title: Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries

description: Abstract Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore, the present study aimed to evaluate the effects of diltiazem, as a calcium channel blocker, and metoprolol, as a β-adrenoceptors antagonist, on I/R injury. In this study, 30 male Wistar rats were divided into control, I/R, metoprolol, diltiazem, and metoprolol plus diltiazem groups (n=6 in each). Metoprolol (1 mg/kg/day) and diltiazem (5 mg/kg/day) were injected intraperitoneally (i.p.) for 7 days before I/R induction. On day 8, the animals underwent ischemia by bilateral common carotid arteries occlusion for 20 min. Histopathological analysis showed a significant reduction in leukocyte infiltration in diltiazem, metoprolol, and diltiazem plus metoprolol treated rats compared with the I/R group (P&lt;0.05, P&lt;0.01, P&lt;0.01, respectively). In addition, in all treated groups, myeloperoxidase activity and malondialdehyde levels in the brain tissue significantly declined compared with the I/R group (P&lt;0.001). Furthermore, pre-treatment with diltiazem and metoprolol alone or in co-administration remarkably reduced infarct size following I/R (P&lt;0.001). Overall, the results indicate the considerable neuroprotective effects of metoprolol and diltiazem in cerebral I/R.
DOI: 10.6084/m9.figshare.21856339.v1
title: Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries

description: Abstract Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore, the present study aimed to evaluate the effects of diltiazem, as a calcium channel blocker, and metoprolol, as a β-adrenoceptors antagonist, on I/R injury. In this study, 30 male Wistar rats were divided into control, I/R, metoprolol, diltiazem, and metoprolol plus diltiazem groups (n=6 in each). Metoprolol (1 mg/kg/day) and diltiazem (5 mg/kg/day) were injected intraperitoneally (i.p.) for 7 days before I/R induction. On day 8, the animals underwent ischemia by bilateral common carotid arteries occlusion for 20 min. Histopathological analysis showed a significant reduction in leukocyte infiltration in diltiazem, metoprolol, and diltiazem plus metoprolol treated rats compared with the I/R group (P&lt;0.05, P&lt;0.01, P&lt;0.01, respectively). In addition, in all treated groups, myeloperoxidase activity and malondialdehyde levels in the brain tissue significantly declined compared with the I/R group (P&lt;0.001). Furthermore, pre-treatment with diltiazem and metoprolol alone or in co-administration remarkably reduced infarct size following I/R (P&lt;0.001). Overall, the results indicate the considerable neuroprotective effects of metoprolol and diltiazem in cerebral I/R.
DOI: 10.6084/m9.figshare.21856344.v1
title: Comparative study of cold hyperalgesia and mechanical allodynia in two animal models of neuropathic pain: different etiologies and distinct pathophysiological mechanisms.

description: Abstract Neuropathic pain (NP) affects more than 8% of the global population. The proposed action of the transient receptor potential ankyrin 1 (TRPA1) as a mechanosensor and the characterization of the transient receptor potential melastatin 8 (TRPM8) as a cold thermosensor raises the question of whether these receptors are implicated in NP. Our study aimed to evaluate the involvement of TRPA1 and TRPM8 in cold and mechanical signal transduction to obtain a comparative view in rat models of streptozotocin-induced diabetes (STZ) and chronic constriction injury of the sciatic nerve (CCI). The electronic von Frey test showed that STZ rats presented mechanical allodynia that was first evidenced on the 14th day after diabetes confirmation, and four days after CCI. This phenomenon was reduced by the intraplantar (ipl) administration of a TRPA1 receptor antagonist (HC-030031; 40 μL/300 μg/paw) in both NP models. Only CCI rats displayed cold hyperalgesia based on the cold plate test. The pharmacological blocking of TRPA1 through the injection of the antagonist attenuated cold hyperalgesia in this NP model. STZ animals showed a reduction in the number of flinches induced by the intraplantar injection of mustard oil (MO; TRPA1 agonist; 0.1%/50 μL/paw), or intraplantar injection of menthol (MT; TRPM8 agonist; 0.5% and 1%/50 μL/paw). The response induced by the ipl administration of MT (1%/50 µL/paw) was significantly different between the CCI and SHAM groups. Together, these data suggest a different pattern in nociceptive behavior associated with different models of NP, suggesting a variant involvement of TRPA1 and TRPM8 in both conditions.
DOI: 10.6084/m9.figshare.21856344
title: Comparative study of cold hyperalgesia and mechanical allodynia in two animal models of neuropathic pain: different etiologies and distinct pathophysiological mechanisms.

description: Abstract Neuropathic pain (NP) affects more than 8% of the global population. The proposed action of the transient receptor potential ankyrin 1 (TRPA1) as a mechanosensor and the characterization of the transient receptor potential melastatin 8 (TRPM8) as a cold thermosensor raises the question of whether these receptors are implicated in NP. Our study aimed to evaluate the involvement of TRPA1 and TRPM8 in cold and mechanical signal transduction to obtain a comparative view in rat models of streptozotocin-induced diabetes (STZ) and chronic constriction injury of the sciatic nerve (CCI). The electronic von Frey test showed that STZ rats presented mechanical allodynia that was first evidenced on the 14th day after diabetes confirmation, and four days after CCI. This phenomenon was reduced by the intraplantar (ipl) administration of a TRPA1 receptor antagonist (HC-030031; 40 μL/300 μg/paw) in both NP models. Only CCI rats displayed cold hyperalgesia based on the cold plate test. The pharmacological blocking of TRPA1 through the injection of the antagonist attenuated cold hyperalgesia in this NP model. STZ animals showed a reduction in the number of flinches induced by the intraplantar injection of mustard oil (MO; TRPA1 agonist; 0.1%/50 μL/paw), or intraplantar injection of menthol (MT; TRPM8 agonist; 0.5% and 1%/50 μL/paw). The response induced by the ipl administration of MT (1%/50 µL/paw) was significantly different between the CCI and SHAM groups. Together, these data suggest a different pattern in nociceptive behavior associated with different models of NP, suggesting a variant involvement of TRPA1 and TRPM8 in both conditions.
DOI: 10.6084/m9.figshare.21856348
title: Strain Echocardiographic Evaluation of Myocardial Involvement in Patients with Continuing Chest Pain after COVID-19 Infection

description: Abstract Background A new clinical manifestation called post or long coronavirus disease (p/l COVID) has walked into our lives after the acute COVID-19 phase. P/l COVID may lead to myocardial injury with subsequent cardiac problems. Diagnosing these patients quickly and simply has become more important due to the increasing number of patients with p/l COVID. Objectives We compared strain echocardiography (SE) parameters of patients who suffered from atypical chest pain and had sequel myocarditis findings on cardiac magnetic resonance (CMR). We aimed to investigate the value of SE for detection of myocardial involvement in patients with p/l COVID. Methods A total of 42 patients were enrolled. Our population was separated into two groups. The CMR(-) group (n = 21) had no myocardial sequelae on CMR, whereas the CMR(+) group had myocardial sequelae on CMR (n = 21). The predictive value of SE for myocarditis was also evaluated by age-adjusted multivariate analysis. P values &lt; 0.05 were considered statistically significant. Results When compared with left ventricular ejection fraction (LVEF), global longitudinal strain (GLS) and global circumferential strain (GCS) had a stronger relationship (LVEF, p = 0.05; GLS, p &lt; 0.001; GCS, p &lt; 0.001) with p/l COVID associated myocardial involvement. GLS &lt; 20.35 had 85.7% sensitivity and 81% specificity; GCS &lt; 21.35 had 81% sensitivity and 81% specificity as diagnostic values for myocardial sequelae detected with CMR. While there was no difference between the groups in terms of inflammatory markers (C-reactive protein, p = 0.31), a difference was observed between biochemical markers, which are indicators of cardiac involvement (brain natriuretic peptide, p &lt; 0.001). Conclusion SE is more useful than traditional echocardiography for making diagnosis quickly and accurately in order not to delay treatment in the presence of myocardial involvement.
DOI: 10.6084/m9.figshare.21856348.v1
title: Strain Echocardiographic Evaluation of Myocardial Involvement in Patients with Continuing Chest Pain after COVID-19 Infection

description: Abstract Background A new clinical manifestation called post or long coronavirus disease (p/l COVID) has walked into our lives after the acute COVID-19 phase. P/l COVID may lead to myocardial injury with subsequent cardiac problems. Diagnosing these patients quickly and simply has become more important due to the increasing number of patients with p/l COVID. Objectives We compared strain echocardiography (SE) parameters of patients who suffered from atypical chest pain and had sequel myocarditis findings on cardiac magnetic resonance (CMR). We aimed to investigate the value of SE for detection of myocardial involvement in patients with p/l COVID. Methods A total of 42 patients were enrolled. Our population was separated into two groups. The CMR(-) group (n = 21) had no myocardial sequelae on CMR, whereas the CMR(+) group had myocardial sequelae on CMR (n = 21). The predictive value of SE for myocarditis was also evaluated by age-adjusted multivariate analysis. P values &lt; 0.05 were considered statistically significant. Results When compared with left ventricular ejection fraction (LVEF), global longitudinal strain (GLS) and global circumferential strain (GCS) had a stronger relationship (LVEF, p = 0.05; GLS, p &lt; 0.001; GCS, p &lt; 0.001) with p/l COVID associated myocardial involvement. GLS &lt; 20.35 had 85.7% sensitivity and 81% specificity; GCS &lt; 21.35 had 81% sensitivity and 81% specificity as diagnostic values for myocardial sequelae detected with CMR. While there was no difference between the groups in terms of inflammatory markers (C-reactive protein, p = 0.31), a difference was observed between biochemical markers, which are indicators of cardiac involvement (brain natriuretic peptide, p &lt; 0.001). Conclusion SE is more useful than traditional echocardiography for making diagnosis quickly and accurately in order not to delay treatment in the presence of myocardial involvement.