cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21865467.v1
title: Supplementary Material for: Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes

description: Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR≥30 ml/min/1.73 m2 if randomization eGFR≥60 or ≥50% if randomization eGFR&lt;60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n=712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onwards). Results: At baseline, mean age was 65 years, mean eGFR was 56 ml/min/1.73 m2, and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully-adjusted models, the highest vs. lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10-40% higher risk of mortality. Discussion/Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality.
DOI: 10.6084/m9.figshare.21865473
title: Supplementary Material for: Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes

description: Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR≥30 ml/min/1.73 m2 if randomization eGFR≥60 or ≥50% if randomization eGFR&lt;60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n=712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onwards). Results: At baseline, mean age was 65 years, mean eGFR was 56 ml/min/1.73 m2, and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully-adjusted models, the highest vs. lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10-40% higher risk of mortality. Discussion/Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality.
DOI: 10.6084/m9.figshare.21865473.v1
title: Supplementary Material for: Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes

description: Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR≥30 ml/min/1.73 m2 if randomization eGFR≥60 or ≥50% if randomization eGFR&lt;60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n=712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onwards). Results: At baseline, mean age was 65 years, mean eGFR was 56 ml/min/1.73 m2, and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully-adjusted models, the highest vs. lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10-40% higher risk of mortality. Discussion/Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality.
DOI: 10.6084/m9.figshare.21865476
title: Supplementary Material for: Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias.

description: Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
DOI: 10.6084/m9.figshare.21865476.v1
title: Supplementary Material for: Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias.

description: Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
DOI: 10.6084/m9.figshare.21865482
title: Supplementary Material for: Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias.

description: Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
DOI: 10.6084/m9.figshare.21865482.v1
title: Supplementary Material for: Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias.

description: Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
DOI: 10.17638/datacat.liverpool.ac.uk/1991
title: Kissane et al. Rat indirect-stimulation metabolomics

description: Rat skeletal muscle (tibialis anterior) derived capillary data, fatigue and metabolomics data. Briefly, rat hindlimbs were indirectly electrically stimulated for 7 days at varying stimulation frequencies. After 7 days of stimulation, muscles were harvested for either muscle histology or metabolomic profiling.
description: See README file.
DOI: 10.21223/nrowhq
title: Dataset for: Surveillance of the potato psyllid and purple top associated to the agricultural landscape in Ecuador from 2018 to 2021

description: The psyllid (Bactericera cockerelli) and purple top are serious productivity concerns for the potato production in Ecuador. Unfortunately, it is still unknown the drivers that facilitate or limit the presence of the psyllid or the purple top in the farmers fields. To contribute to this gap of knowledge, we constructed a dataset with: (1) the surveillance information provided by Agrocalidad since 2018 until 2021 and (2) the surveys of agricultural area and productivity of Ecuador from 2018 until 2021. In this file, you can find two databases. The "surveillance_psyllid" sheet refers to the surveillance of potato psyllid and the agricultural landscape composition present during the moment of data collection with 951 observations. The "surveillance_pmp" sheet contains information of purple top and the agricultural landscape composition present during the moment of data collection with 309 observations. It is expected that this information contributes to understand better the drivers that affect the presence of the potato psyllid and purple top in the Andes, and support the decision making to manage the potato psyllid and purple top.
DOI: 10.6084/m9.figshare.21865494
title: Supplementary Material for: Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias.

description: Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
DOI: 10.6084/m9.figshare.21865494.v1
title: Supplementary Material for: Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias.

description: Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
DOI: 10.5281/zenodo.7319965
title: Confocal data of Sphaerius martini and Crowsonaerius minutus

description: This dataset contains the raw confocal laser scanning microscopy (CLSM) slices for holotypes of <em>Sphaerius martini</em> (NIGP178177) and <em>Crowsonaerius minutus</em> (NIGP178178). This dataset is associated with the publication "New fossils of Sphaeriusidae from mid-Cretaceous Burmese amber revealed by confocal microscopy (Coleoptera: Myxophaga)" (DOI:10.3389/feart.2022.901573). Confocal images were obtained with a Zeiss LSM710 confocal laser scanning microscope, using the 488 nm (Argon) laser excitation line. The original CZI files are provided, which could be opened by the ZEISS ZEN software.
DOI: 10.5281/zenodo.7319964
title: Confocal data of Sphaerius martini and Crowsonaerius minutus

description: This dataset contains the raw confocal laser scanning microscopy (CLSM) slices for holotypes of <em>Sphaerius martini</em> (NIGP178177) and <em>Crowsonaerius minutus</em> (NIGP178178). This dataset is associated with the publication "New fossils of Sphaeriusidae from mid-Cretaceous Burmese amber revealed by confocal microscopy (Coleoptera: Myxophaga)" (DOI:10.3389/feart.2022.901573). Confocal images were obtained with a Zeiss LSM710 confocal laser scanning microscope, using the 488 nm (Argon) laser excitation line. The original CZI files are provided, which could be opened by the ZEISS ZEN software.
DOI: 10.34740/kaggle/dsv/4839094
title: Distrinet-CIC-IDS2017
DOI: 10.5281/zenodo.7525742
title: dataset related to article "LESSONS LEARNED FROM THE LESSONS LEARNED IN PUBLIC HEALTH DURING THE FIRST YEARS OF COVID-19 PANDEMIC" in press

description: THE DATABASE CONTAINS THE DATA EXTRACTION FORM USED TO RECORD DATA FROM THE STUDIES INCLUDED IN THE REVIEW, WHICH JOURNAL, YEAR, AUTHORS, TITLE, GEOGRAPHIC AREA OF THE STUDY (WHO REGIONS), AND PARTICIPANTS’ INFORMATION (NUMBER AND MEAN AGE) WERE REPORTED. IN THIS FORM, DATA HAVE BEEN DIVIDED INTO 10 MAIN SECTIONS, ONE FOR EACH WHO PUBLIC HEALTH PILLAR. IN EACH SECTION, A DEFINITION OF THE PUBLIC HEALTH AREA COVERED BY THE PILLAR, THE TOTAL NUMBER OF ARTICLES LINKED TO THE PILLAR, THE TOTAL NUMBER OF AVAILABLE LESSONS CONNECTED TO EACH PILLAR, AS WELL AS THE TOTAL NUMBER OF REFERENCES TO EACH LESSON LEARNED WITHIN EACH PILLAR (WHICH CONSTITUTES THE MAIN RESULT) WAS INCLUDED.
DOI: 10.5281/zenodo.7525741
title: dataset related to article "LESSONS LEARNED FROM THE LESSONS LEARNED IN PUBLIC HEALTH DURING THE FIRST YEARS OF COVID-19 PANDEMIC" in press

description: THE DATABASE CONTAINS THE DATA EXTRACTION FORM USED TO RECORD DATA FROM THE STUDIES INCLUDED IN THE REVIEW, WHICH JOURNAL, YEAR, AUTHORS, TITLE, GEOGRAPHIC AREA OF THE STUDY (WHO REGIONS), AND PARTICIPANTS’ INFORMATION (NUMBER AND MEAN AGE) WERE REPORTED. IN THIS FORM, DATA HAVE BEEN DIVIDED INTO 10 MAIN SECTIONS, ONE FOR EACH WHO PUBLIC HEALTH PILLAR. IN EACH SECTION, A DEFINITION OF THE PUBLIC HEALTH AREA COVERED BY THE PILLAR, THE TOTAL NUMBER OF ARTICLES LINKED TO THE PILLAR, THE TOTAL NUMBER OF AVAILABLE LESSONS CONNECTED TO EACH PILLAR, AS WELL AS THE TOTAL NUMBER OF REFERENCES TO EACH LESSON LEARNED WITHIN EACH PILLAR (WHICH CONSTITUTES THE MAIN RESULT) WAS INCLUDED.
DOI: 10.6084/m9.figshare.21865500
title: Supplementary Material for: Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes

description: Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR≥30 ml/min/1.73 m2 if randomization eGFR≥60 or ≥50% if randomization eGFR&lt;60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n=712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onwards). Results: At baseline, mean age was 65 years, mean eGFR was 56 ml/min/1.73 m2, and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully-adjusted models, the highest vs. lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10-40% higher risk of mortality. Discussion/Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality.
DOI: 10.6084/m9.figshare.21865500.v1
title: Supplementary Material for: Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes

description: Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR≥30 ml/min/1.73 m2 if randomization eGFR≥60 or ≥50% if randomization eGFR&lt;60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n=712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onwards). Results: At baseline, mean age was 65 years, mean eGFR was 56 ml/min/1.73 m2, and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully-adjusted models, the highest vs. lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10-40% higher risk of mortality. Discussion/Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality.