cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.15505889.v1
title: Chronic constipation is negatively associated with colonic diverticula

description: Constipation has been considered the key risk factor for diverticulosis occurrence, but the underlying mechanism is unclear. We investigated the factors associated with diverticulosis, focusing on the association of constipation severity with the localization and number of diverticula. We analyzed consecutive patients who underwent colonoscopy between March and December 2019. Chronic constipation was diagnosed as constipation meeting Rome IV criteria or as that requiring laxative therapy for more than 6 months. The degree of constipation was scored using the Constipation Scoring System (CSS). We assessed 1014 patients. Multivariate analysis revealed that age, alcohol consumption, and hypertension were positively associated with diverticulosis, whereas chronic constipation was negatively associated with diverticulosis (odds ratio [OR] = 0.74; 95% confidence interval [CI], 0.55–0.99). When assessed according to the location of diverticula, right-sided diverticula were significantly associated with a lower incidence of constipation (OR = 0.94; 95% CI, 0.89–0.98), whereas neither left-sided nor bilateral diverticula was associated with constipation. This negative association of diverticula with constipation was stronger in patients with a high CSS score. In stratified analysis, the number of diverticula decreased with increasing degree of constipation (<i>p</i> for trend &lt;.01), and a high CSS score was associated with a decreased prevalence of ≥3 diverticula (OR = 0.64; 95% CI, 0.44–0.99). Chronic constipation was negatively associated with colonic diverticulosis. The association increased with the degree of constipation and was strong only in cases with right-sided diverticula and those with ≥3 diverticula.
DOI: 10.5281/zenodo.7667391
title: Social knowledge and irony understanding

description: Dataset accompanying the publication titled "Impact of social knowledge about the speaker on irony understanding: Evidence from neural oscillations." It contains EEG recording (.set and .fdt files) of 22 participants reading stories during a task of irony undertsanding. Stimuli were manipulated according to a context condition (ironic, literal) and a speaker occupation stereotype (no occupation, non-sarcastic, sarcastic). Matlab scripts used for preprocessing and time-frequency analysis are available on github: https://github.com/deebeebolger/project_Ironie2022.git
DOI: 10.5281/zenodo.7667390
title: Social knowledge and irony understanding

description: Dataset accompanying the publication titled "Impact of social knowledge about the speaker on irony understanding: Evidence from neural oscillations." It contains EEG recording (.set and .fdt files) of 22 participants reading stories during a task of irony undertsanding. Stimuli were manipulated according to a context condition (ironic, literal) and a speaker occupation stereotype (no occupation, non-sarcastic, sarcastic). Matlab scripts used for preprocessing and time-frequency analysis are available on github: https://github.com/deebeebolger/project_Ironie2022.git
DOI: 10.5281/zenodo.7670487
title: Datset related to article "DUPLICATION OF EXONS 15 AND 16 IN MATRIN-3: A PHENOTYPE BRIDGING AMYOTROPHIC LATERAL SCLEROSIS AND IMMUNE-MEDIATED DISORDERS"

description: <strong>NGS analysis performed at Fondazione Besta carried out as part of the study reported at title </strong>
description: funding: FONDAZIONE REGIONALE PER LA RICERCA BIOMEDICA (REGIONE LOMBARDIA,GRANT FRRB 2015–0023)
DOI: 10.5281/zenodo.7670486
title: Datset related to article "DUPLICATION OF EXONS 15 AND 16 IN MATRIN-3: A PHENOTYPE BRIDGING AMYOTROPHIC LATERAL SCLEROSIS AND IMMUNE-MEDIATED DISORDERS"

description: <strong>NGS analysis performed at Fondazione Besta carried out as part of the study reported at title </strong>
description: funding: FONDAZIONE REGIONALE PER LA RICERCA BIOMEDICA (REGIONE LOMBARDIA,GRANT FRRB 2015–0023)
DOI: 10.5281/zenodo.7670530
title: Inappropriate Expenditure Dataset

description: Please read the Code Book/ Author: Tomohiro Hosoi 1. About the Dataset This dataset contains information on the amount of inappropriate expenditure in the South African Public Sector. The Public Finance Management Act (PFMA) regulates National and Provincial organs, while the Municipal Finance Management Act (MFMA) does Local Government (Metropolitan Municipality, Local Municipality and District Municipality). The dataset aims to estimate how much an institution uses its budget inappropriately. 2. Procedure The Auditor-General of South Africa releases information on inappropriate expenditures in their annual reports. The Auditor General classifies three categories; (i) unauthorised expenditure; (ii) irregular expenditure; and (iii) fruitless and wasteful expenditure. The author sums up (i) to (iii) and names it “inappropriate expenditure”. The author also collects the annual expenditure of each institution from the national budget and Statistics South Africa’s releases. Then, the author calculates the share of inappropriate expenditure compared with total expenditure. The author named it an “inappropriate expenditure ratio”. The data are shown in both PFMA and MFMA respectively.
DOI: 10.5281/zenodo.7670529
title: Inappropriate Expenditure Dataset

description: Please read the Code Book/ Author: Tomohiro Hosoi 1. About the Dataset This dataset contains information on the amount of inappropriate expenditure in the South African Public Sector. The Public Finance Management Act (PFMA) regulates National and Provincial organs, while the Municipal Finance Management Act (MFMA) does Local Government (Metropolitan Municipality, Local Municipality and District Municipality). The dataset aims to estimate how much an institution uses its budget inappropriately. 2. Procedure The Auditor-General of South Africa releases information on inappropriate expenditures in their annual reports. The Auditor General classifies three categories; (i) unauthorised expenditure; (ii) irregular expenditure; and (iii) fruitless and wasteful expenditure. The author sums up (i) to (iii) and names it “inappropriate expenditure”. The author also collects the annual expenditure of each institution from the national budget and Statistics South Africa’s releases. Then, the author calculates the share of inappropriate expenditure compared with total expenditure. The author named it an “inappropriate expenditure ratio”. The data are shown in both PFMA and MFMA respectively.
DOI: 10.6084/m9.figshare.22133933.v1
title: Supplementary Material for: Pigmented Nevus of the Caruncle and Plica Semilunaris: A Case Report

description: Conjunctival nevi are benign, heterogenous tumors that uncommonly arise from the lacrimal caruncle and plica semilunaris. We present a case of a patient diagnosed and managed for an unusual, pigmented nevus of the left caruncle involving the plica. An 84-year-old woman presented with a rapidly growing, pigmented lesion in her left nasal canthus. Examination demonstrated a raised, dark, pigmented area arising from the left caruncle and seeming to involve the plica semilunaris without scleral extension. The lesion was completely excised for histopathology, which confirmed the diagnosis of a compound nevus with pigment incontinence. Given the unfavorable anatomical position and prognostic significance in the case of malignancy, pigmented caruncular lesions should be thoroughly investigated with a low threshold for surgical removal.
DOI: 10.6084/m9.figshare.22109576.v1
title: Supplementary Material for: Androgen deprivation therapy for intracranial metastasis of a salivary duct carcinoma – case report

description: Salivary duct carcinoma (SDC) is a rare subtype of salivary cancers associated with androgen receptor and human epidermal growth factor receptor 2 (HER2/neu) overexpression. It shows a high propensity to give rise to distant metastases mainly to the lung, the bone and the liver. Intracranial metastases are rare. We report the case of a 61-year-old male patient with SDC developing intracranial metastases. Unresponsive to radiotherapy and anti-HER/neu targeted therapy the intracranial metastases showed a very good partial remission to androgen deprivation therapy (ADT) with goserelin acetate. This case demonstrates the potential of a highly targeted therapy with a relatively cheap and well-known drug in a patient with a rare disease without other good therapeutic options, which is a good example of modern, personalized medicine.
DOI: 10.5281/zenodo.7670562
title: Datset related to article "G507D MUTATION IN FUS GENE CAUSES FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS WITH A SPECIFIC GENOTYPE-PHENOTYPE CORRELATION"

description: <strong>NGS_analysis performed at Fondazione Besta carried out as part of the study reported at title</strong>
description: FUNDING: ITALIAN MINISTRY OF HEALTH [GRANT RF 2013-02355764 AND GR-2016-02364373]
DOI: 10.5281/zenodo.7670561
title: Datset related to article "G507D MUTATION IN FUS GENE CAUSES FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS WITH A SPECIFIC GENOTYPE-PHENOTYPE CORRELATION"

description: <strong>NGS_analysis performed at Fondazione Besta carried out as part of the study reported at title</strong>
description: FUNDING: ITALIAN MINISTRY OF HEALTH [GRANT RF 2013-02355764 AND GR-2016-02364373]
DOI: 10.34740/kaggle/dsv/5050807
title: COVID Vaccination in World (updated daily)
DOI: 10.5281/zenodo.7670552
title: South African Public Protector Investigate Reports Data

description: Please read the Code Book. Author: Tomohiro Hosoi <strong>Aim of the Data Set</strong> The South African Public Protector Investigate Reports Data is the original data constructed by Tomohiro Hosoi (“the author”), who aims to investigate the role of the Public Protector in South Africa. His research article titled “South African Public Protector: People’s Watchdog or Politicians’ Lapdog?” which is published in <em>African Study Monographs </em>2023, uses this data set. The author aims to share the dataset for researchers to more sophisticated research in the future. The author provides the data in both excel and CSV format. <strong>Source of the Data</strong> The author downloaded all of the Investigation Reports on the Office of Public Protector’s Home Page on 15 April 2022. (http://www.publicprotector.org/?q=content/investigation-reports-categories). The data includes 388 reports from 2008 to 2022. The author reads all of the reports and codes the information containing them.
DOI: 10.5281/zenodo.7670551
title: South African Public Protector Investigate Reports Data

description: Please read the Code Book. Author: Tomohiro Hosoi <strong>Aim of the Data Set</strong> The South African Public Protector Investigate Reports Data is the original data constructed by Tomohiro Hosoi (“the author”), who aims to investigate the role of the Public Protector in South Africa. His research article titled “South African Public Protector: People’s Watchdog or Politicians’ Lapdog?” which is published in <em>African Study Monographs </em>2023, uses this data set. The author aims to share the dataset for researchers to more sophisticated research in the future. The author provides the data in both excel and CSV format. <strong>Source of the Data</strong> The author downloaded all of the Investigation Reports on the Office of Public Protector’s Home Page on 15 April 2022. (http://www.publicprotector.org/?q=content/investigation-reports-categories). The data includes 388 reports from 2008 to 2022. The author reads all of the reports and codes the information containing them.
DOI: 10.5281/zenodo.7670564
title: DATASET RELATED TO ARTICLE "MISSENSE MUTATION IN ATXN2 GENE (C.2860C &gt; T) IN AN AMYOTROPHIC LATERAL SCLEROSIS PATIENT WITH AGGRESSIVE DISEASE PHENOTYPE"

description: <strong>NGS_analysis PERFORMED AT fONDAZIONE BESTA AND CARRIED OUT AS PART OF THE STUDY MENTIONED AT TITLE</strong>
DOI: 10.5281/zenodo.7670563
title: DATASET RELATED TO ARTICLE "MISSENSE MUTATION IN ATXN2 GENE (C.2860C &gt; T) IN AN AMYOTROPHIC LATERAL SCLEROSIS PATIENT WITH AGGRESSIVE DISEASE PHENOTYPE"

description: <strong>NGS_analysis PERFORMED AT fONDAZIONE BESTA AND CARRIED OUT AS PART OF THE STUDY MENTIONED AT TITLE</strong>
DOI: 10.5519/qd.j24ux83h
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (447 records)
DOI: 10.5281/zenodo.7670591
title: Discovery of a Seven-Coordinated High Pressure CrSb2 Phase: Experimental Equation of State of TMSb2 (TM = Cr, Fe, Ru, Os)

description: DFT calculations from: Discovery of a Seven-Coordinated High Pressure CrSb2 Phase: Experimental Equation of State of TMSb2 (TM = Cr, Fe, Ru, Os); Emma Ehrenreich-Petersen, Mads F. Hansen, Justin Jeanneau, Davide Ceresoli, Francesca Menescardi, Martin Ottesen, Vitali Prakapenka, Sergey N. Tkachev and Martin Bremholm; submitted to Inorg. Chem. (2023)
DOI: 10.5281/zenodo.7670590
title: Discovery of a Seven-Coordinated High Pressure CrSb2 Phase: Experimental Equation of State of TMSb2 (TM = Cr, Fe, Ru, Os)

description: DFT calculations from: Discovery of a Seven-Coordinated High Pressure CrSb2 Phase: Experimental Equation of State of TMSb2 (TM = Cr, Fe, Ru, Os); Emma Ehrenreich-Petersen, Mads F. Hansen, Justin Jeanneau, Davide Ceresoli, Francesca Menescardi, Martin Ottesen, Vitali Prakapenka, Sergey N. Tkachev and Martin Bremholm; submitted to Inorg. Chem. (2023)
DOI: 10.5281/zenodo.7670607
title: Dataset related to article "BEHAVIORAL AND COGNITIVE PHENOTYPES OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS CARRYING SOD1 VARIANTS"

description: <strong>ngs_analysis performedn as part of the study mentioned at title</strong>
description: Funding: FONDAZIONE REGIONALE PER LA RICERCA BIOMEDICA, REGIONE LOMBARDIA (TRANS-ALS; GRANT NUMBER:2015-0023), FONDO EUROPEO DI SVILUPPO REGIONALE, REGIONE LOMBARDIA (POR FESR 2014-2020; GRANT NUMBER 1157625),AND THE ITALIAN MINISTRY OF HEALTH (RRC)
DOI: 10.5281/zenodo.7670606
title: Dataset related to article "BEHAVIORAL AND COGNITIVE PHENOTYPES OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS CARRYING SOD1 VARIANTS"

description: <strong>ngs_analysis performedn as part of the study mentioned at title</strong>
description: Funding: FONDAZIONE REGIONALE PER LA RICERCA BIOMEDICA, REGIONE LOMBARDIA (TRANS-ALS; GRANT NUMBER:2015-0023), FONDO EUROPEO DI SVILUPPO REGIONALE, REGIONE LOMBARDIA (POR FESR 2014-2020; GRANT NUMBER 1157625),AND THE ITALIAN MINISTRY OF HEALTH (RRC)
DOI: 10.35078/6ykaza
title: Ficha epidemiológica de localidade: Distrito: Teófilo Otoni| Município: Itambacuri

description: Levantamento Triatomínico com operações de campo ocorridas em Minas Gerais pela Superintendência de Campanhas de Saúde Pública (SUCAM) e FUNASA (Fundação Nacional de Saúde), no período de 1979 a 1999, objetivando a busca da presença de vetores da doença de Chagas ou de vestígios dessa presença. A partir dela são orientadas as operações com inseticida (pt) Triatomine survey with field operations carried out in Minas Gerais by the Public Health Campaigns Superintendence (SUCAM) and FUNASA (National Health Foundation), from 1979 to 1999, aiming to search for the presence of Chagas disease vectors or traces of that presence. From it, operations with insecticide are guided (en) Encuesta de triatominos con operaciones de campo realizada en Minas Gerais por la Superintendencia de Campañas de Salud Pública (SUCAM) y FUNASA (Fundación Nacional de Salud), de 1979 a 1999, con el objetivo de buscar la presencia de vectores de la enfermedad de Chagas o rastros de esa presencia. Desde ella se orientan las operaciones con insecticida (es)
DOI: 10.6084/m9.figshare.14705042
title: MMP-9-mediated regulation of hypoxia-reperfusion injury-related neutrophil inflammation in an <i>in vitro</i> proximal tubular cell model

description: Hypoxia-reperfusion (HR) and inflammation are causes of renal allograft injury. Pathological evidence has indicated that ischemia followed by reperfusion leads to the proteolysis and destruction of the extracellular matrix (ECM) in renal tubular epithelial cells. Matrix metalloproteinases (MMPs), such as MMP-2 and MMP-9, play roles in cleaving and reshaping the ECM. Acute accumulation of MMP-9 secreted from neutrophils promotes the incidence of inflammation and exacerbates graft trauma. Our goal was to investigate the activities of MMP-9/MMP-2 and their correlation with HR injury and neutrophil-related inflammation in renal proximal tubular cells. This model was established by placing HK-2 cells under hypoxic conditions (5% CO<sub>2</sub>, 1% O<sub>2</sub>) for 6 h and then exposing them to reperfusion (5% CO<sub>2</sub>, 21% O<sub>2</sub>) for 12 h in a tri-gas incubator. The cell culture medium was collected for culturing polymorphonuclear leukocytes (PMNs). BB-94 (MMP-9 inhibitor) was added to the culture medium in the inhibitor group. Flow cytometry showed a significant increase in reactive oxygen species (ROS) levels in HK-2 cells from the HR injury group. MMP-9 expression was significantly increased and MMP-2 expression was significantly decreased in HK-2 cells from the HR group. MMP-9 and MPO expression were significantly increased in the HR group, while MPO expression was significantly decreased in the PMN inhibitor group. The outcomes indicated that MMP-9 and MMP-2 are important components of an underlying pathophysiological mechanism of injury following HR. MMP-9 inhibition may be a potential approach to mitigateHR injury.
DOI: 10.6084/m9.figshare.14705042.v1
title: MMP-9-mediated regulation of hypoxia-reperfusion injury-related neutrophil inflammation in an <i>in vitro</i> proximal tubular cell model

description: Hypoxia-reperfusion (HR) and inflammation are causes of renal allograft injury. Pathological evidence has indicated that ischemia followed by reperfusion leads to the proteolysis and destruction of the extracellular matrix (ECM) in renal tubular epithelial cells. Matrix metalloproteinases (MMPs), such as MMP-2 and MMP-9, play roles in cleaving and reshaping the ECM. Acute accumulation of MMP-9 secreted from neutrophils promotes the incidence of inflammation and exacerbates graft trauma. Our goal was to investigate the activities of MMP-9/MMP-2 and their correlation with HR injury and neutrophil-related inflammation in renal proximal tubular cells. This model was established by placing HK-2 cells under hypoxic conditions (5% CO<sub>2</sub>, 1% O<sub>2</sub>) for 6 h and then exposing them to reperfusion (5% CO<sub>2</sub>, 21% O<sub>2</sub>) for 12 h in a tri-gas incubator. The cell culture medium was collected for culturing polymorphonuclear leukocytes (PMNs). BB-94 (MMP-9 inhibitor) was added to the culture medium in the inhibitor group. Flow cytometry showed a significant increase in reactive oxygen species (ROS) levels in HK-2 cells from the HR injury group. MMP-9 expression was significantly increased and MMP-2 expression was significantly decreased in HK-2 cells from the HR group. MMP-9 and MPO expression were significantly increased in the HR group, while MPO expression was significantly decreased in the PMN inhibitor group. The outcomes indicated that MMP-9 and MMP-2 are important components of an underlying pathophysiological mechanism of injury following HR. MMP-9 inhibition may be a potential approach to mitigateHR injury.
DOI: 10.6084/m9.figshare.17153429
title: Incidence and risk factors of acute kidney injury in COVID-19 patients with and without acute respiratory distress syndrome (ARDS) during the first wave of COVID-19: a systematic review and Meta-Analysis

description: Acute kidney injury (AKI) is common among patients with COVID-19. However, AKI incidence may increase when COVID-19 patients develop acute respiratory distress syndrome (ARDS). Thus, this systematic review and meta-analysis aimed to assess the incidence and risk factors of AKI, need for kidney replacement therapy (KRT), and mortality rate among COVID-19 patients with and without ARDS from the first wave of COVID-19. The databases MEDLINE and EMBASE were searched using relevant keywords. Only articles available in English published between December 1, 2019, and November 1, 2020, were included. Studies that included AKI in COVID-19 patients with or without ARDS were included. Meta-analyses were conducted using random-effects models. Out of 618 studies identified and screened, 31 studies met the inclusion criteria. A total of 27,500 patients with confirmed COVID-19 were included. The overall incidence of AKI in patients with COVID-19 was 26% (95% CI 19% to 33%). The incidence of AKI was significantly higher among COVID-19 patients with ARDS than COVID-19 patients without ARDS (59% vs. 6%, <i>p</i> &lt; 0.001). Comparing ARDS with non-ARDS COVID-19 cohorts, the need for KRT was also higher in ARDS cohorts (20% vs. 1%). The mortality among COVID-19 patients with AKI was significantly higher (Risk ratio = 4.46; 95% CI 3.31–6; <i>p</i> &lt; 0.00001) than patients without AKI. This study shows that ARDS development in COVID-19-patients leads to a higher incidence of AKI and increased mortality rate. Therefore, healthcare providers should be aware of kidney dysfunction, especially among elderly patients with multiple comorbidities. Early kidney function assessment and treatments are vital in COVID-19 patients with ARDS.
DOI: 10.6084/m9.figshare.17153429.v1
title: Incidence and risk factors of acute kidney injury in COVID-19 patients with and without acute respiratory distress syndrome (ARDS) during the first wave of COVID-19: a systematic review and Meta-Analysis

description: Acute kidney injury (AKI) is common among patients with COVID-19. However, AKI incidence may increase when COVID-19 patients develop acute respiratory distress syndrome (ARDS). Thus, this systematic review and meta-analysis aimed to assess the incidence and risk factors of AKI, need for kidney replacement therapy (KRT), and mortality rate among COVID-19 patients with and without ARDS from the first wave of COVID-19. The databases MEDLINE and EMBASE were searched using relevant keywords. Only articles available in English published between December 1, 2019, and November 1, 2020, were included. Studies that included AKI in COVID-19 patients with or without ARDS were included. Meta-analyses were conducted using random-effects models. Out of 618 studies identified and screened, 31 studies met the inclusion criteria. A total of 27,500 patients with confirmed COVID-19 were included. The overall incidence of AKI in patients with COVID-19 was 26% (95% CI 19% to 33%). The incidence of AKI was significantly higher among COVID-19 patients with ARDS than COVID-19 patients without ARDS (59% vs. 6%, <i>p</i> &lt; 0.001). Comparing ARDS with non-ARDS COVID-19 cohorts, the need for KRT was also higher in ARDS cohorts (20% vs. 1%). The mortality among COVID-19 patients with AKI was significantly higher (Risk ratio = 4.46; 95% CI 3.31–6; <i>p</i> &lt; 0.00001) than patients without AKI. This study shows that ARDS development in COVID-19-patients leads to a higher incidence of AKI and increased mortality rate. Therefore, healthcare providers should be aware of kidney dysfunction, especially among elderly patients with multiple comorbidities. Early kidney function assessment and treatments are vital in COVID-19 patients with ARDS.