cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31420451
title: Supplementary Material for: Primary Care Physicians’ Perspectives on Primary Immunodeficiency Diseases (Inborn Errors of Immunity)

description: Introduction: Primary immunodeficiency diseases (PIDs) are a heterogeneous group of genetic disorders associated with recurrent infections, immune dysregulation, and increased morbidity and mortality when diagnosis is delayed. Primary care physicians (PCPs) play a critical role in early recognition; however, data on PCPs' knowledge and preparedness regarding PID remain limited. This study aimed to evaluate PCPs' knowledge, clinical approaches, and preparedness regarding PIDs across Türkiye.
Methods: This nationwide, cross-sectional study included 385 PCPs-general practitioners (GPs), family medicine residents (FMRs), and family medicine specialists (FMSs)- working in Family Health Centers in Türkiye. Participants completed a structured online questionnaire assessing sociodemographic characteristics, educational background, clinical experience, self-perceived PID knowledge, and performance on 15 PID-related multiple-choice questions based on international guidelines. Total knowledge scores (range: 0–15) were calculated. Correct response rates for individual items and total scores were compared across professional groups and according to educational and clinical variables. Multivariable logistic regression analyses were performed to identify factors independently associated with higher knowledge scores.
Results: The mean total knowledge score was 9.09 ± 2.46 (range 0–15). FMSs significantly higher total scores than FMRs and GPs (GPs 8.67 ± 2.47; FMRs 8.82 ± 2.63; FMSs 9.83 ± 2.03; p &lt; 0.001). In multivariable analysis, being an FMS was independently associated with scoring above the mean (OR = 2.02, 95% CI: 1.26–3.23; p = 0.004). Regular participation in general medical educational activities was associated with significantly higher total scores (9.74 ± 2.31 vs. 8.23 ± 2.38; p &lt; 0.001). PCPs who participated in PID-related educational activities within the past five years were also associated with higher total scores (9.43 ± 2.58 vs. 8.87 ± 2.47; p = 0.027). PCPs who reported requesting immunoglobulin testing or referring patients with recurrent lower respiratory tract infections achieved significantly higher total scores (9.18 ± 2.43 vs. 7.52 ± 2.42; p = 0.001). PCPs who self-perceived their PID knowledge as moderate or good had substantially higher total knowledge scores compared to those who self-perceived their knowledge as low (Low: 8.36 ± 2.55; Moderate: 9.41 ± 2.26; Good: 10.09 ± 2.50; p &lt; 0.001).
Conclusion: PID-related knowledge scores among PCPs differed across professional groups, with GPs demonstrating lower scores. Higher knowledge scores were significantly associated with being an FMS and with participation in regular general medical education and past 5 year PID-related education. Strengthening targeted educational strategies, particularly for GPs in primary care settings, may improve early recognition and management of PIDs.
DOI: 10.6084/m9.figshare.31420451.v1
title: Supplementary Material for: Primary Care Physicians’ Perspectives on Primary Immunodeficiency Diseases (Inborn Errors of Immunity)

description: Introduction: Primary immunodeficiency diseases (PIDs) are a heterogeneous group of genetic disorders associated with recurrent infections, immune dysregulation, and increased morbidity and mortality when diagnosis is delayed. Primary care physicians (PCPs) play a critical role in early recognition; however, data on PCPs' knowledge and preparedness regarding PID remain limited. This study aimed to evaluate PCPs' knowledge, clinical approaches, and preparedness regarding PIDs across Türkiye.
Methods: This nationwide, cross-sectional study included 385 PCPs-general practitioners (GPs), family medicine residents (FMRs), and family medicine specialists (FMSs)- working in Family Health Centers in Türkiye. Participants completed a structured online questionnaire assessing sociodemographic characteristics, educational background, clinical experience, self-perceived PID knowledge, and performance on 15 PID-related multiple-choice questions based on international guidelines. Total knowledge scores (range: 0–15) were calculated. Correct response rates for individual items and total scores were compared across professional groups and according to educational and clinical variables. Multivariable logistic regression analyses were performed to identify factors independently associated with higher knowledge scores.
Results: The mean total knowledge score was 9.09 ± 2.46 (range 0–15). FMSs significantly higher total scores than FMRs and GPs (GPs 8.67 ± 2.47; FMRs 8.82 ± 2.63; FMSs 9.83 ± 2.03; p &lt; 0.001). In multivariable analysis, being an FMS was independently associated with scoring above the mean (OR = 2.02, 95% CI: 1.26–3.23; p = 0.004). Regular participation in general medical educational activities was associated with significantly higher total scores (9.74 ± 2.31 vs. 8.23 ± 2.38; p &lt; 0.001). PCPs who participated in PID-related educational activities within the past five years were also associated with higher total scores (9.43 ± 2.58 vs. 8.87 ± 2.47; p = 0.027). PCPs who reported requesting immunoglobulin testing or referring patients with recurrent lower respiratory tract infections achieved significantly higher total scores (9.18 ± 2.43 vs. 7.52 ± 2.42; p = 0.001). PCPs who self-perceived their PID knowledge as moderate or good had substantially higher total knowledge scores compared to those who self-perceived their knowledge as low (Low: 8.36 ± 2.55; Moderate: 9.41 ± 2.26; Good: 10.09 ± 2.50; p &lt; 0.001).
Conclusion: PID-related knowledge scores among PCPs differed across professional groups, with GPs demonstrating lower scores. Higher knowledge scores were significantly associated with being an FMS and with participation in regular general medical education and past 5 year PID-related education. Strengthening targeted educational strategies, particularly for GPs in primary care settings, may improve early recognition and management of PIDs.
DOI: 10.13018/bmr2951
title: Assessment of cheY binding regions using 2D NMR and paramagnetic ligands
DOI: 10.13018/bmr2956
title: Importance of Protein and DNA Phosphate Ester Backbone Flexibility in Protein-DNA Recognition
DOI: 10.6084/m9.figshare.31420454
title: Supplementary Material for: Impact of transitioning from Race-specific to Race-neutral GLI equation on lung function in a predominantly Caucasian population

description: Introduction
Diagnosis and treatment decisions for many respiratory diseases are based on spirometric values. We compared the impact of changing the reference equations from GLI-2012 (race-specific) to GLI-2022 (race-neutral) in a predominantly Caucasian urban population.

Methods
PneumoLaus is a sub-study of CoLaus|PsyCoLaus, an ongoing prospective observational study conducted in Lausanne, Switzerland. Participants performed spirometry at baseline (2014-2017) and at follow-up (2018-2021, FU). We analysed changes of %predicted values (PV) for Forced Expiratory Volume in One second (FEV1) and Forced Vital Capacity (FVC) by comparing the GLI-2022 reference equation to GLI-2012. Sub-group analyses were performed for social class, sex and age using paired t-tests corrected by Holm-Bonferroni. We analysed the association of age, sex and social class on the differences using linear regression.

Results
A total of 3330 participants were included at baseline and 2005 at FU, &gt;97% Caucasian. Employing GLI-2022 equations, the %PV increased significantly for both FEV1 (4.2%PV and +0.31 Z-score baseline, 4.6%PV and +0.28 Z-score FU, both p&lt;0.0001) and FVC (4.9%PV and +0.34 Z-score baseline, 5.6%PV and + 0.29 Z-score FU, both p&lt;0.0001). Younger individuals, males, and participants with only compulsory school education experienced the greatest increase. The prevalence of low FEV₁ and low FVC decreased using GLI-2022 references, while the prevalence of obstructive ventilatory impairment increased at baseline and FU (all p&lt;0.05).

Discussion
In this predominantly Caucasian urban population-based cohort, applying GLI-2022 equations led to a general FEV1 and FVC %PV increase, particularly among younger individuals, males, and participants with only compulsory school education. Applying GLI-2022 equations also led to a general FEV1 and FVC z-score increase. These findings changes may carry relevant implications for clinical care and social policy decisions.
DOI: 10.13018/bmr2957
title: Complete Assignment of the 1H NMR Spectrum of the Aromatic Residues of Lysozyme
DOI: 10.6084/m9.figshare.31420454.v1
title: Supplementary Material for: Impact of transitioning from Race-specific to Race-neutral GLI equation on lung function in a predominantly Caucasian population

description: Introduction
Diagnosis and treatment decisions for many respiratory diseases are based on spirometric values. We compared the impact of changing the reference equations from GLI-2012 (race-specific) to GLI-2022 (race-neutral) in a predominantly Caucasian urban population.

Methods
PneumoLaus is a sub-study of CoLaus|PsyCoLaus, an ongoing prospective observational study conducted in Lausanne, Switzerland. Participants performed spirometry at baseline (2014-2017) and at follow-up (2018-2021, FU). We analysed changes of %predicted values (PV) for Forced Expiratory Volume in One second (FEV1) and Forced Vital Capacity (FVC) by comparing the GLI-2022 reference equation to GLI-2012. Sub-group analyses were performed for social class, sex and age using paired t-tests corrected by Holm-Bonferroni. We analysed the association of age, sex and social class on the differences using linear regression.

Results
A total of 3330 participants were included at baseline and 2005 at FU, &gt;97% Caucasian. Employing GLI-2022 equations, the %PV increased significantly for both FEV1 (4.2%PV and +0.31 Z-score baseline, 4.6%PV and +0.28 Z-score FU, both p&lt;0.0001) and FVC (4.9%PV and +0.34 Z-score baseline, 5.6%PV and + 0.29 Z-score FU, both p&lt;0.0001). Younger individuals, males, and participants with only compulsory school education experienced the greatest increase. The prevalence of low FEV₁ and low FVC decreased using GLI-2022 references, while the prevalence of obstructive ventilatory impairment increased at baseline and FU (all p&lt;0.05).

Discussion
In this predominantly Caucasian urban population-based cohort, applying GLI-2022 equations led to a general FEV1 and FVC %PV increase, particularly among younger individuals, males, and participants with only compulsory school education. Applying GLI-2022 equations also led to a general FEV1 and FVC z-score increase. These findings changes may carry relevant implications for clinical care and social policy decisions.
DOI: 10.13018/bmr2958
title: High-resolution Three-Dimensional Structure of Reduced Recombinant Human Thioredoxin in Solution
DOI: 10.6084/m9.figshare.31420457
title: Supplementary Material for: Gene expression profiling of peripheral blood and endometrial cancer risk factors: Systems epidemiology approach in the NOWAC Postgenome Cohort Study

description: The increasing incidence of endometrial cancer (EC) requires an extensive search for novel preventive tools and early intervention approaches. However, the establishment of reliable predictive models is impossible without knowledge of genetic changes prior to diagnosis. In
3
this work, we aimed to establish whether known EC risk factors influence peripheral blood gene expression in a prospective design.
First, we selected variables (parity status, lifetime number of years of menstruation, coffee consumption, BMI, age of menopause, use of oral contraceptives) that were shown to have an impact on EC risk in a big prospective cohort (165,000 women). Next, using BeadChip microarray technology, we tested the association between these variables and changes in gene expression profiles in blood in a nested case-control study (79 case-control pairs) of women from the NOWAC postgenome cohort. Lastly, we undertook a gene set enrichment analysis (GSEA).
At overall gene expression level, we found no difference between the EC cases and controls. The introduction of parity status into the statistical model, revealed changes in the expression of 1,379 genes in the controls, while we did not observe any expression changes in the cases. Twenty-seven genes were associated with BMI increase in the controls, whereas there was no association observed between changes in BMI and gene expression in women with EC. In GSEA, 2407 significantly enriched gene sets were attributed to a parity increase among cancer-free women.
In this study, we found that an increased number of parities have a life-long effect on the gene expression profile in the peripheral blood of women who never developed cancer, while neither multiparity nor elevated BMI changed the gene expression in women diagnosed with EC later in life.
DOI: 10.6084/m9.figshare.31420457.v1
title: Supplementary Material for: Gene expression profiling of peripheral blood and endometrial cancer risk factors: Systems epidemiology approach in the NOWAC Postgenome Cohort Study

description: The increasing incidence of endometrial cancer (EC) requires an extensive search for novel preventive tools and early intervention approaches. However, the establishment of reliable predictive models is impossible without knowledge of genetic changes prior to diagnosis. In
3
this work, we aimed to establish whether known EC risk factors influence peripheral blood gene expression in a prospective design.
First, we selected variables (parity status, lifetime number of years of menstruation, coffee consumption, BMI, age of menopause, use of oral contraceptives) that were shown to have an impact on EC risk in a big prospective cohort (165,000 women). Next, using BeadChip microarray technology, we tested the association between these variables and changes in gene expression profiles in blood in a nested case-control study (79 case-control pairs) of women from the NOWAC postgenome cohort. Lastly, we undertook a gene set enrichment analysis (GSEA).
At overall gene expression level, we found no difference between the EC cases and controls. The introduction of parity status into the statistical model, revealed changes in the expression of 1,379 genes in the controls, while we did not observe any expression changes in the cases. Twenty-seven genes were associated with BMI increase in the controls, whereas there was no association observed between changes in BMI and gene expression in women with EC. In GSEA, 2407 significantly enriched gene sets were attributed to a parity increase among cancer-free women.
In this study, we found that an increased number of parities have a life-long effect on the gene expression profile in the peripheral blood of women who never developed cancer, while neither multiparity nor elevated BMI changed the gene expression in women diagnosed with EC later in life.
DOI: 10.13018/bmr2959
title: High-resolution Three-Dimensional Structure of Reduced Recombinant Human Thioredoxin in Solution
DOI: 10.13018/bmr2960
title: Computer-Aided Sequential Assignment of Protein 1H NMR Spectra
DOI: 10.13018/bmr2968
title: Hydrogen exchange in Pseudomonas cytochrome c-551
DOI: 10.13018/bmr2990
title: Different conformations for the same polypeptide bound to chaperones DnaK and GroEL
DOI: 10.15468/dl.3ehfut
title: Occurrence Download

description: A dataset containing 329 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "TaxonKey is Terminalia chebula",
 "Year 2000-2026"
 ]
}

 The dataset includes 329 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002738-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr2991
title: Different conformations for the same polypeptide bound to chaperones DnaK and GroEL
DOI: 10.13018/bmr2999
title: Sequence-Specific Assignments of the 1H Nuclear Magnetic Resonance Spectra of Reduced High-Potential Ferredoxin (HiPIP) from Chromatium vinosum
DOI: 10.13018/bmr3000
title: Sequence-Specific Assignments of the 1H Nuclear Magnetic Resonance Spectra of Reduced High-Potential Ferredoxin (HiPIP) from Chromatium vinosum
DOI: 10.15468/dl.he2hwd
title: Occurrence Download

description: A dataset containing 326 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Terminalia chebula",
 "Year 1993-2026"
 ]
}

 The dataset includes 326 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002739-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nzssvt
title: Occurrence Download

description: A dataset containing 443 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Hong Kong, Chinese Taipei, Macao)",
 "OccurrenceStatus is Present",
 "TaxonKey is Vespula flaviceps"
 ]
}

 The dataset includes 443 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002741-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr3032
title: Changing the Inhibitory Specificity and Function of the Proteinase Inhibitor Eglin c by Site-Directed Mutagenesis: Functional and Structural Investigation
DOI: 10.13018/bmr3036
title: Effect of Trifluoroethanol on Protein Secondary Structure: An NMR and CD Study Using a Synthetic Actin Peptide
DOI: 10.15468/dl.wz8pvy
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is India",
 "OccurrenceStatus is Present",
 "TaxonKey is Pinus kesiya",
 "Year 2000-2026"
 ]
}

 The dataset includes 10 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002742-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13018/bmr3065
title: Studies of the structure of bacteriophage lambda cro protein in solution Analysis of the aromatic region of the 1H NMR spectrum
DOI: 10.13018/bmr3078
title: 1H NMR Assignments and Secondary Structure of Human beta2-Microglobulin in Solution
DOI: 10.13018/bmr3079
title: 1H NMR Assignments and Secondary Structure of Human beta2-Microglobulin in Solution
DOI: 10.13018/bmr3084
title: The interaction of acetate and formate with cobalt carbonic anhydrase An NMR study
DOI: 10.13018/bmr3085
title: The interaction of acetate and formate with cobalt carbonic anhydrase An NMR study
DOI: 10.13018/bmr3118
title: Stoichiometry of Calcium Binding to a Synthetic Heterodimeric Troponin-C Domain
DOI: 10.6084/m9.figshare.31420460
title: Supplementary figures from Mitonuclear dynamics in unisexual vertebrates

description: SuppTables.xlsx
DOI: 10.6084/m9.figshare.31420460.v1
title: Supplementary figures from Mitonuclear dynamics in unisexual vertebrates

description: SuppTables.xlsx
DOI: 10.13018/bmr3119
title: Stoichiometry of Calcium Binding to a Synthetic Heterodimeric Troponin-C Domain
DOI: 10.13018/bmr3127
title: Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein
DOI: 10.13018/bmr3128
title: Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein
DOI: 10.13018/bmr3322
title: Characterisation of a cellulosome dockerin domain from the anaerobic fungus Piromyces equi
DOI: 10.13018/bmr3394
title: The solution structure of the leucine zipper motif of the Jun oncoprotein homodimer
DOI: 10.13018/bmr3404
title: A Single-Stranded Amphiphatic alpha-Helix in Aqueous Solution: Design, Structural Characterization, and Its Application for Determining alpha-Helical Propensities of Amino Acids
DOI: 10.13018/bmr3427
title: NMR Solution Structure of Human Parathyroid Hormone(1-34)
DOI: 10.13018/bmr3433
title: 1H and 15N assignments and secondary structure of the Src Sh3 domain
DOI: 10.13018/bmr3435
title: Proton NMR Conformational Study of an Annexin I Fragment: Influence of a Phospholipidic Micellar Environment
DOI: 10.13018/bmr3436
title: Proton NMR Conformational Study of an Annexin I Fragment: Influence of a Phospholipidic Micellar Environment
DOI: 10.13018/bmr3437
title: Proton NMR Conformational Study of an Annexin I Fragment: Influence of a Phospholipidic Micellar Environment
DOI: 10.13018/bmr3440
title: 1H- and 15N-NMR assignment and solution structure of the chemotactic Escherichia coli Che Y protein
DOI: 10.13018/bmr3441
title: 1H-NMR analysis of turkey egg-white lysozyme and comparison with hen egg-white lysozyme
DOI: 10.13018/bmr3442
title: Sequential assignment of proton resonances in the NMR spectrum of Zn-substituted alpha chains from human hemoglobin
DOI: 10.13018/bmr3449
title: Stabilized NMR structure of human parathyroid hormone(1-34)
DOI: 10.13018/bmr3456
title: Two-dimensional 1H NMR study of recombinant insect defensin A in water: Resonance assignments, secondary structure and global folding
DOI: 10.13018/bmr3466
title: Proton Nuclear Magnetic Resonance Sequential Assignments and Secondary Structure of an Immunoglobulin Light Chain-Binding Domain of Protein L
DOI: 10.13018/bmr3471
title: Symmetrical Rearrangement of the Cation-Binding Sites of Parvalbumin upon Ca2+/Mg2+ Exchange. A Study by 1H 2D NMR
DOI: 10.13018/bmr3472
title: Symmetrical Rearrangement of the Cation-Binding Sites of Parvalbumin upon Ca2+/Mg2+ Exchange. A Study by 1H 2D NMR
DOI: 10.13018/bmr3485
title: 1H-n.m.r. study of the solution properties and secondary structure of neurotoxin III from the sea anemone Anemonia sulcata
DOI: 10.13018/bmr3524
title: 13C NMR Determination of the Tautomeric and Ionization States of Folate in Its Complexes with Lactobacillus casei Dihydrofolate Reductase
DOI: 10.13018/bmr3525
title: 13C NMR Determination of the Tautomeric and Ionization States of Folate in Its Complexes with Lactobacillus casei Dihydrofolate Reductase
DOI: 10.13018/bmr3548
title: Two-dimensional nuclear magnetic resonance study of brain natriuretic peptide in aqueous solution.
DOI: 10.13018/bmr4001
title: 1H, 13C, and 15N resonance assignments for reduced apo-S100beta
DOI: 10.13018/bmr4010
title: Resonance Assignments for the OB-fold Sub-Domain of Staphylococcal Nuclease(SNOB) -&gt; Nuclease 1-103 (V66L, G88V)
DOI: 10.13018/bmr4011
title: 1H and 15N Assignments and Secondary Structure of the Starch-binding Domain of Glucoamylase from Aspergillus niger
DOI: 10.15468/dl.2c6y8j
title: Occurrence Download

description: A dataset containing 79 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN.29_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Aethopyga gouldiae"
 ]
}

 The dataset includes 79 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002743-260225131425191/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.57760/sciencedb.27812
title: Anti-aging effects of Lactiplantibacillus plantarum HFY15 and its improvement on exercise function in mice
title: Anti-aging effects of Lactiplantibacillus plantarum HFY15 and its improvement on exercise function in mice

description: Data from the paper "Anti aging effects of Lactiplantibacillus plantarum HFY15 and its improvement on exercise function in mice"
description: Data from the paper "Anti aging effects of Lactiplantibacillus plantarum HFY15 and its improvement on exercise function in mice"
DOI: 10.13018/bmr4012
title: Structure of the Acid State of E. coli Ribonuclease HI
DOI: 10.13018/bmr4019
title: 1H, 13C and 15N Resonance Assignments of Recombinant Poplar Plastocyanin
DOI: 10.13018/bmr4020
title: Solution Structure of the Immunodominant Region of Protein G of Bovine Respiratory Syncytial Virus