cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9205196
title: Synthesis and reactions of 4<i>H</i>-3,1-benzoxazin-4-one derivative bearing pyrazolyl moiety as antimicrobial and antioxidant agents

description: Ring opening of 4-aryl-2-phenyloxazol-5-one <b>1</b> with 2-aminobenzoic acid in acetic acid and <i>n</i>-butanol gave compounds <b>2</b> and <b>3</b>, respectively. The 4<i>H</i>-3,1-benzoxazin-4-one derivative <b>4</b> was synthesized by refluxing of compound <b>2</b> in acetic anhydride. Then it reacted with different nitrogen nucleophiles such as hydrazine hydrate, phenylhydrazine, cyclohexylamine, piperidine, ethylenediamine, ethanolamine, semicarbazide hydrochloride, cyanoacetohydrazide and methyl glycinate hydrochloride to give compounds <b>5–14</b> in order to study the behavior of these nucleophilic reagents on the performed ring system. All the structures of the newly prepared compounds were characterized by their IR, <sup>1</sup>H-, 13C-NMR and MS spectral data. Some of the synthesized compounds were screened for their antimicrobial and antioxidant activities. Compound <b>5</b> showed remarkable activity upon this screening.
DOI: 10.17637/rh.9205184
title: Geospatial Data: Impact of communal irrigation on the 2018 Palu earthquake-triggered landslides

description: Digital data repository for Watkinson, I. M. and Hall, R., Impact of communal irrigation on the 2018 Palu earthquake-triggered landslides<br><br>Nature Geoscience Manuscript NGS-2018-12-02760<br>Submitted 21st December 2018; revised version submitted 11th June 2019; accepted 18th July 2019.<br><br>Contents include vector files for ArcGIS (shapefiles).<br>All files use the projected coordinate system UTM zone 50S, WGS1984.<br>All shapefiles are also provided as KMZ files for use in Google Earth.<br>Files are provided as-is and without guarantees in terms of accuracy, reliability or significance. We accept no liability for use of these files under any circumstances. See main manuscript, Methods section and supplementary materials for full description and uncertainties. <br><br>Contents:<br><br>*** Landslide displacement geospatial data ***<br>---------------------------------------------<br>- Observed_displacement_lines_MAIN.shp/kmz (main high-density object tracking lines)<br>- Observed_displacement_points_START.shp/kmz (main high-density object tracking lines start points)<br>- Observed_displacement_points_END.shp/kmz (main high-density object tracking lines end points)<br>- Observed_displacement_lines_WIDER.shp/kmz (main high-density object tracking lines plus lower density lines in wider study area for PCA)<br><br>*** Landslide features geospatial data ***<br>----------------------------------------<br>- Landslide_domains.shp/kmz<br>- Landslide_faults_fractures.shp/kmz<br>- Mottling.shp/kmz<br>- Sand_blows.shp/kmz<br>- Water_ponding.shp/kmz<br><br>*** Irrigation/water geospatial data ***<br>-----------------------------------------------<br>- Conveyance_canal.shp/kmz<br>- Irrigation_nodes.shp/kmz<br>- Other_channels.shp/kmz<br>- Natural_rivers.shp/kmz<br><br>*** Spreadsheets ***<br>--------------------------<br>- Observed_displacement_data.xlsx<br>- RESULT_PCA_FULL and 1-10_formatted for publication.xlsx
DOI: 10.6084/m9.figshare.9205196.v2
title: Synthesis and reactions of 4<i>H</i>-3,1-benzoxazin-4-one derivative bearing pyrazolyl moiety as antimicrobial and antioxidant agents

description: Ring opening of 4-aryl-2-phenyloxazol-5-one <b>1</b> with 2-aminobenzoic acid in acetic acid and <i>n</i>-butanol gave compounds <b>2</b> and <b>3</b>, respectively. The 4<i>H</i>-3,1-benzoxazin-4-one derivative <b>4</b> was synthesized by refluxing of compound <b>2</b> in acetic anhydride. Then it reacted with different nitrogen nucleophiles such as hydrazine hydrate, phenylhydrazine, cyclohexylamine, piperidine, ethylenediamine, ethanolamine, semicarbazide hydrochloride, cyanoacetohydrazide and methyl glycinate hydrochloride to give compounds <b>5–14</b> in order to study the behavior of these nucleophilic reagents on the performed ring system. All the structures of the newly prepared compounds were characterized by their IR, <sup>1</sup>H-, 13C-NMR and MS spectral data. Some of the synthesized compounds were screened for their antimicrobial and antioxidant activities. Compound <b>5</b> showed remarkable activity upon this screening.
DOI: 10.17637/rh.9205184.v1
title: Geospatial Data

description: Digital data repository for Watkinson, I. M. and Hall, R., Impact of communal irrigation on the 2018 Palu earthquake-triggered landslides<br><br>Nature Geoscience Manuscript NGS-2018-12-02760<br>Submitted 21st December 2018; revised version submitted 11th June 2019; accepted 18th July 2019.<br><br>Contents include vector files for ArcGIS (shapefiles).<br>All files use the projected coordinate system UTM zone 50S, WGS1984.<br>All shapefiles are also provided as KMZ files for use in Google Earth.<br>Files are provided as-is and without guarantees in terms of accuracy, reliability or significance. We accept no liability for use of these files under any circumstances. See main manuscript, Methods section and supplementary materials for full description and uncertainties. <br><br>Contents:<br><br>*** Landslide displacement geospatial data ***<br>---------------------------------------------<br>- Observed_displacement_lines_MAIN.shp/kmz (main high-density object tracking lines)<br>- Observed_displacement_points_START.shp/kmz (main high-density object tracking lines start points)<br>- Observed_displacement_points_END.shp/kmz (main high-density object tracking lines end points)<br>- Observed_displacement_lines_WIDER.shp/kmz (main high-density object tracking lines plus lower density lines in wider study area for PCA)<br><br>*** Landslide features geospatial data ***<br>----------------------------------------<br>- Landslide_domains.shp/kmz<br>- Landslide_faults_fractures.shp/kmz<br>- Mottling.shp/kmz<br>- Sand_blows.shp/kmz<br>- Water_ponding.shp/kmz<br><br>*** Irrigation/water geospatial data ***<br>-----------------------------------------------<br>- Conveyance_canal.shp/kmz<br>- Irrigation_nodes.shp/kmz<br>- Other_channels.shp/kmz<br>- Natural_rivers.shp/kmz<br><br>*** Spreadsheets ***<br>--------------------------<br>- Observed_displacement_data.xlsx<br>- RESULT_PCA_FULL and 1-10_formatted for publication.xlsx
DOI: 10.6084/m9.figshare.9205163
title: Incidence of solid cancer in patients with follicular lymphoma

description: <b>Introduction:</b> Patients with follicular lymphoma (FL) have classically had a higher risk of solid cancers than the general population, but there is little data available in patients diagnosed and treated with modern day regimens. <b>Material and methods:</b> We conducted a retrospective multicenter study assessing the cumulative incidence of solid cancers other than nonmelanoma skin cancer in patients with FL between 1997 and 2016 and determined the standardized incidence ratio (SIR) to compare the incidence of solid cancers with that of the general population <b>Results:</b> Among 1002 FL patients with 7 years of median follow-up, we found 74 solid cancers (most common breast [<i>n</i> = 19], lung and colon [<i>n</i> = 9 each]). The cumulative incidence was 3.8% at 5 years (95%CI 2.6–5.2) from the time of diagnosis and 4.4% at 5 years (95%CI 3.1–5.9%) from the time of front-line treatment. Although a comparison of all front-line strategies did not reveal differences in the risk of solid cancers, patients treated with anthracycline-based regimens appeared to have a lower incidence than those treated with bendamustine-based strategies (2.8% vs. 6.9%). However, patients receiving the former regimen were younger than the latter. On multivariable analysis, older age was correlated with the incidence of solid cancer and bendamustine-based treatment was of borderline significance. SIR for any solid cancer was 1.22 (95%CI 0.91–1.64), indicating no increased risk of solid cancer in patients with FL over that of the general population. However, on subgroup analyses, female patients treated with bendamustine-based strategies appeared to have a greater risk (SIR 3.85 [95%CI 1.45–10.27]) <b>Discussion:</b> The incidence of solid cancer in this cohort of patients with FL was low and not greater than in the general population. However, the risk may be greater in female patients treated with bendamustine.
DOI: 10.6084/m9.figshare.9205163.v1
title: Incidence of solid cancer in patients with follicular lymphoma

description: <b>Introduction:</b> Patients with follicular lymphoma (FL) have classically had a higher risk of solid cancers than the general population, but there is little data available in patients diagnosed and treated with modern day regimens. <b>Material and methods:</b> We conducted a retrospective multicenter study assessing the cumulative incidence of solid cancers other than nonmelanoma skin cancer in patients with FL between 1997 and 2016 and determined the standardized incidence ratio (SIR) to compare the incidence of solid cancers with that of the general population <b>Results:</b> Among 1002 FL patients with 7 years of median follow-up, we found 74 solid cancers (most common breast [<i>n</i> = 19], lung and colon [<i>n</i> = 9 each]). The cumulative incidence was 3.8% at 5 years (95%CI 2.6–5.2) from the time of diagnosis and 4.4% at 5 years (95%CI 3.1–5.9%) from the time of front-line treatment. Although a comparison of all front-line strategies did not reveal differences in the risk of solid cancers, patients treated with anthracycline-based regimens appeared to have a lower incidence than those treated with bendamustine-based strategies (2.8% vs. 6.9%). However, patients receiving the former regimen were younger than the latter. On multivariable analysis, older age was correlated with the incidence of solid cancer and bendamustine-based treatment was of borderline significance. SIR for any solid cancer was 1.22 (95%CI 0.91–1.64), indicating no increased risk of solid cancer in patients with FL over that of the general population. However, on subgroup analyses, female patients treated with bendamustine-based strategies appeared to have a greater risk (SIR 3.85 [95%CI 1.45–10.27]) <b>Discussion:</b> The incidence of solid cancer in this cohort of patients with FL was low and not greater than in the general population. However, the risk may be greater in female patients treated with bendamustine.
DOI: 10.6084/m9.figshare.9205196.v1
title: Synthesis and reactions of 4<i>H</i>-3,1-benzoxazin-4-one derivative bearing pyrazolyl moiety as antimicrobial and antioxidant agents

description: Ring opening of 4-aryl-2-phenyloxazol-5-one <b>1</b> with 2-aminobenzoic acid in acetic acid and <i>n</i>-butanol gave compounds <b>2</b> and <b>3</b>, respectively. The 4<i>H</i>-3,1-benzoxazin-4-one derivative <b>4</b> was synthesized by refluxing of compound <b>2</b> in acetic anhydride. Then it reacted with different nitrogen nucleophiles such as hydrazine hydrate, phenylhydrazine, cyclohexylamine, piperidine, ethylenediamine, ethanolamine, semicarbazide hydrochloride, cyanoacetohydrazide and methyl glycinate hydrochloride to give compounds <b>5–14</b> in order to study the behavior of these nucleophilic reagents on the performed ring system. All the structures of the newly prepared compounds were characterized by their IR, <sup>1</sup>H-, 13C-NMR and MS spectral data. Some of the synthesized compounds were screened for their antimicrobial and antioxidant activities. Compound <b>5</b> showed remarkable activity upon this screening.
DOI: 10.6084/m9.figshare.9205004
title: Data

description: Raw data of sexting and emotional difficulties
DOI: 10.6084/m9.figshare.9204992
title: Early-life intestinal microbiome in Trachemys scripta elegans analyzed using 16S rRNA Sequencing

description: Intestinal microbiome of red-eard slider turtle analyzed by 16S rRNA sequencing<br>
DOI: 10.6084/m9.figshare.9205004.v1
title: Data

description: Raw data of sexting and emotional difficulties
DOI: 10.6084/m9.figshare.9204992.v1
title: Early-life intestinal microbiome in Trachemys scripta elegans analyzed using 16S rRNA Sequencing

description: Intestinal microbiome of red-eard slider turtle analyzed by 16S rRNA sequencing<br>
DOI: 10.6084/m9.figshare.9204773
title: Extended data on the study titled 'management and cost of snakebite injuries at a teaching and referral hospital in Western Kenya'

description: This data contains information on the ethical approval document issued for the study on management and cost of snakebite at a teaching and referral hospital in Western Kenya, the hospitals that referred snakebite victims, and the financial waiver issued to snakebite victims. <br>
DOI: 10.6084/m9.figshare.9204998.v1
title: Genome-Wide Association Study of the Frailty Index - Atkins et al. 2019

description: Genome-wide summary statistics from the GWAS analysis of the Frailty Index in UK Biobank participants of European descent aged 60 to 70 years.<br>Preprint available https://doi.org/10.1101/19007559<br>We used a Frailty Index (FI) based on the accumulation of deficits model (Searle et al. 2008), as validated in UK Biobank previously for its ability to predict all-cause mortality (Williams et al. 2018). The FI was derived using 49 self-reported baseline data variables in UK Biobank. Variables were based on a variety of physiological and mental health domains, and included symptoms, disabilities and diagnosed diseases, which were self-reported by participants at baseline. The FI was generated using a complete-case sample with information on all 49 individual components and presented as a proportion of the sum of all deficits. The FI was quantile normalised (i.e. transformed into a normal distribution) prior to the genome-wide association study (due to the skew of the untransformed trait). The analysis included 164,610 participants of European descent aged 60 to 70 with complete Frailty Index data. <br><br>Results are from UK Biobank genetic data release version 3 (including imputation from HRC and the combined UK10K and 1000 Genomes panels) including 16.4million genetic variants that met the following criteria: minor allele frequency (MAF) &gt;0.1%, Hardy-Weinberg p-value &gt;1x10-9, and imputation quality &gt;0.3. We used the BOLT-LMM (v2.3.2) software used for the GWAS itself (Loh et al. 2015), which uses linear mixed-effects modelling to account for genetic relatedness and confounding by ancestry. Models included age, sex, assessment centre (22 categories), and genotyping array (two categories: Axiom or BiLEVE) as covariates. <br><br>If used please cite paper Atkins et al. 2019 "A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in Healthy Aging"<br>Fields are as follows:<br> SNP: dbSNP name of genetic marker, if available<br> CHR: chromosome<br> BP: base-pair position on CHR (hg19 / b37)<br> ALLELE1: effect allele<br> ALLELE0: non-effect allele<br> A1FREQ: frequency of ALLELE1INFO: Imputation quality<br>BETA: effect size from BOLT-LMM approximation to infinitesimal mixed model with respect to ALLELE1<br> SE: standard error of effect size<br> P_BOLT_LMM: non-infinitesimal mixed model association test p-value
DOI: 10.6084/m9.figshare.9204617
title: D1700912（SAMN09662867）.fq

description: Intesetinal microbiome of 0-day red-eared slider<br>
DOI: 10.6084/m9.figshare.9204773.v1
title: Supplementary data on the snakebite study at JOOTRH

description: This data contains information on the ethical approval document issued for the study on management and cost of snakebite at a teaching and referral hospital in Western Kenya, the hospitals that referred snakebite victims, the financial waiver issued to victims ,and snakebite related factors influencing the total indirect cost of snakebite <br>
DOI: 10.6084/m9.figshare.9204617.v1
title: D1700912（SAMN09662867）.fq

description: Intesetinal microbiome of 0-day red-eared slider<br>
DOI: 10.6084/m9.figshare.9204773.v2
title: Supplementary data on the study titled 'management and cost of snakebite injuries at a teaching and referral hospital in Western Kenya'

description: This data contains information on the ethical approval document issued for the study on management and cost of snakebite at a teaching and referral hospital in Western Kenya, the hospitals that referred snakebite victims, the financial waiver issued to victims ,and snakebite related factors influencing the total indirect cost of snakebite <br>
DOI: 10.6084/m9.figshare.9204773.v3
title: Extended data on the study titled 'management and cost of snakebite injuries at a teaching and referral hospital in Western Kenya'

description: This data contains information on the ethical approval document issued for the study on management and cost of snakebite at a teaching and referral hospital in Western Kenya, the hospitals that referred snakebite victims, the financial waiver issued to victims ,and snakebite related factors influencing the total indirect cost of snakebite <br>
DOI: 10.6084/m9.figshare.9204584
title: ESCRT-mediated phagophore sealing during mitophagy

description: Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in macroautophagy/autophagy remain incompletely understood. Using live-cell fluorescence microscopy we found that the filament-forming ESCRT-III subunit CHMP4B was recruited transiently to nascent autophagosomes during starvation-induced autophagy and mitophagy, with residence times of about 1 and 2 min, respectively. Correlative light microscopy and electron tomography revealed CHMP4B recruitment at a late step in mitophagosome formation. The autophagosomal dwell time of CHMP4B was strongly increased by depletion of the regulatory ESCRT-III subunit CHMP2A. Using a novel optogenetic closure assay we observed that depletion of CHMP2A inhibited phagophore sealing during mitophagy. Consistent with this, depletion of CHMP2A and other ESCRT-III subunits inhibited both PRKN/PARKIN-dependent and -independent mitophagy. We conclude that the ESCRT machinery mediates phagophore closure, and that this is essential for mitophagic flux. <b>Abbreviations:</b> BSA: bovine serum albumin; CHMP: chromatin-modifying protein; CLEM: correlative light and electron microscopy; EGFP: enhanced green fluorescent protein; ESCRT: endosomal sorting complex required for transport; HEPES: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid; HRP: horseradish peroxidase; ILV: intralumenal vesicle; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; LOV2: light oxygen voltage 2; MLS: mitochondrial localization sequence; MT-CO2: mitochondrially encoded cytochrome c oxidase II; O+A: oligomycin and antimycin A; PBS: phosphate-buffered saline; PIPES: piperazine-N,N-bis(2-ethanesulfonic acid); PRKN/PARKIN: parkin RBR E3 ubiquitin protein ligase; RAB: RAS-related in brain; SD: standard deviation; SEM: standard error of the mean; TOMM20: TOMM20: translocase of outer mitochondrial membrane 20; VCL: vinculin; VPS4: vacuolar protein sorting protein 4; Zdk1: Zdark 1; TUBG: Tubulin gamma chain
DOI: 10.6084/m9.figshare.9204581
title: Slowing-down reduction and Possible Reversal Trend of Tropospheric NO2 over China during 2016 to 2019

description: Atmospheric nitrogen dioxide (NO<sub>2</sub>) over China at national level has been kept reducing since 2011 as seen from both satellite observations, ground-based measurements and bottom-up emission inventory. After 2016, however, a significant slowing-down of the reduction trend and/or even a reversal trend were found in numerous provinces, particularly in those with heavy NO<sub>2</sub> level, based on satellite observations. Error analysis on satellite data excluded cloud contamination, instrument anomalies from the main reasons of this change. Ground-based measurements show strong positive temporal correlations with satellite observations and similar spatial patterns of year-to-year changes of NO<sub>2</sub> in 2018 and 2019 winter time. The reason for the recent change from surface emission perspective cannot be traced down since the national emission inventory was not updated since 2015. We therefore call on immediate attentions from both scientist community and policy makers to this phenomenon.
DOI: 10.6084/m9.figshare.9204584.v2
title: ESCRT-mediated phagophore sealing during mitophagy

description: Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in macroautophagy/autophagy remain incompletely understood. Using live-cell fluorescence microscopy we found that the filament-forming ESCRT-III subunit CHMP4B was recruited transiently to nascent autophagosomes during starvation-induced autophagy and mitophagy, with residence times of about 1 and 2 min, respectively. Correlative light microscopy and electron tomography revealed CHMP4B recruitment at a late step in mitophagosome formation. The autophagosomal dwell time of CHMP4B was strongly increased by depletion of the regulatory ESCRT-III subunit CHMP2A. Using a novel optogenetic closure assay we observed that depletion of CHMP2A inhibited phagophore sealing during mitophagy. Consistent with this, depletion of CHMP2A and other ESCRT-III subunits inhibited both PRKN/PARKIN-dependent and -independent mitophagy. We conclude that the ESCRT machinery mediates phagophore closure, and that this is essential for mitophagic flux. <b>Abbreviations:</b> BSA: bovine serum albumin; CHMP: chromatin-modifying protein; CLEM: correlative light and electron microscopy; EGFP: enhanced green fluorescent protein; ESCRT: endosomal sorting complex required for transport; HEPES: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid; HRP: horseradish peroxidase; ILV: intralumenal vesicle; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; LOV2: light oxygen voltage 2; MLS: mitochondrial localization sequence; MT-CO2: mitochondrially encoded cytochrome c oxidase II; O+A: oligomycin and antimycin A; PBS: phosphate-buffered saline; PIPES: piperazine-N,N-bis(2-ethanesulfonic acid); PRKN/PARKIN: parkin RBR E3 ubiquitin protein ligase; RAB: RAS-related in brain; SD: standard deviation; SEM: standard error of the mean; TOMM20: TOMM20: translocase of outer mitochondrial membrane 20; VCL: vinculin; VPS4: vacuolar protein sorting protein 4; Zdk1: Zdark 1; TUBG: Tubulin gamma chain
DOI: 10.6084/m9.figshare.9204773.v4
title: Extended data on the study titled 'management and cost of snakebite injuries at a teaching and referral hospital in Western Kenya'

description: This data contains information on the ethical approval document issued for the study on management and cost of snakebite at a teaching and referral hospital in Western Kenya, the hospitals that referred snakebite victims, the financial waiver issued to victims ,and snakebite related factors influencing the total indirect cost of snakebite <br>
DOI: 10.6084/m9.figshare.9204581.v1
title: Slowing-down reduction and Possible Reversal Trend of Tropospheric NO2 over China during 2016 to 2019

description: Atmospheric nitrogen dioxide (NO<sub>2</sub>) over China at national level has been kept reducing since 2011 as seen from both satellite observations, ground-based measurements and bottom-up emission inventory. After 2016, however, a significant slowing-down of the reduction trend and/or even a reversal trend were found in numerous provinces, particularly in those with heavy NO<sub>2</sub> level, based on satellite observations. Error analysis on satellite data excluded cloud contamination, instrument anomalies from the main reasons of this change. Ground-based measurements show strong positive temporal correlations with satellite observations and similar spatial patterns of year-to-year changes of NO<sub>2</sub> in 2018 and 2019 winter time. The reason for the recent change from surface emission perspective cannot be traced down since the national emission inventory was not updated since 2015. We therefore call on immediate attentions from both scientist community and policy makers to this phenomenon.