cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.4824591
title: Antidiabetic activities of Bolanthus spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes

description: Diabetes mellitus (DM) is a metabolic disorder with chronic hyperglycemia featured by metabolic outcomes owing to insufficient insulin secretion and/or insulin effect defect. It is critical to investigate new therapeutic approaches for T2DM and alternative, natural agents that target molecules in potential signal pathways. Medicinal plants are significant resources in the research of alternative new drug active ingredients. Bolanthus spergulifolius (B. spergulifolius)is one of the generaof the family Caryophyllaceae. In this study,it was explored the potentialanti-diabetic effects in vitroof B. spergulifolius extractson 3T3-L1 adipocytes.The total phenolic contents (TPC) of methanolic (MeOH), ethyl acettate (EA) and aqueous extracts of B. spergulifoliuswere evaluated via Folin-Ciocateau. B. spergulifoliusextracts showing highly TPC (Aqueous&lt; MeOH&lt; EA) and their different concentrations were carried out on preadipocytes differentiated in to mature 3T3-L1 adipocytesto investigate their half-maximal (50%) inhibitory concentration (IC50) value by using Thiazolyl blue tetrazolium bromide (MTT) assay. The IC50 of MeOH, EA and Aqueous extracts were observed as 305.7 ± 5.583 µg/mL, 567.4 ± 3.008 µg/mL, and 418.3 ± 4.390 µg/mL and used for further experiments.A live/dead assay further confirmed the cytotoxic effects of MeOH, EA and Aqueous extracts(respectively, 69.75 ± 1.70%, 61.75 ± 1.70%, 70 ± 4.24%, and for all p&lt; 0.05). Also, effects of extracts on lipid accumulation in mature 3T3-L1 adipocyteswere evaluated by Oil-Red O staining assay. The extractseffectively decreasedlipid-accumulation compared to untreated adipocytes(for all p&lt; 0.05).Moreover, effect of extracts on apoptosis regulated by the Baxand Bcl-2was investigated by quantitative reverse transcription polymerase chain reaction (qRT-PCR).Theextractssignificantly induced apoptosis by up-regulating pro-apoptoticBaxexpression but down-regulatedanti-apoptoticBcl-2gene expression compared to untreated adipocytes(for all p&lt; 0.05).The Glut-4expression linked with insulin resistance was determined by qRT-PCR, Western-blot analysis, and immunofluorescence staining.In parallel, the expression of Glut-4 in adipocytes treated with extracts was significantlyhigher compared to untreated adipocytes(for all p&lt; 0.05). Extracts significantly suppressed cell migration after 30 h of wounding in a scratch-assay(for all p&lt; 0.05). Cell morphology and diameter were further evaluated by phase-contrast microscopy, scanning electron microscopy, Immunofluorescence with F-Actin and Giemsa staining. The adipocytes treated with extracts partially lost spherical morphology and showed smaller cell-diameter compared to untreated adipocytes (for all p&lt; 0.05). In conclusion, these results suggest thatextracts of B. spergulifoliuscause to an induce apoptosis, decrease lipid-accumulation, woundhealing, up-regulating Glut-4 level and might contribute to reducing of insulin-resistance in DM.
DOI: 10.5281/zenodo.4824590
title: Antidiabetic activities of Bolanthus spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes

description: Diabetes mellitus (DM) is a metabolic disorder with chronic hyperglycemia featured by metabolic outcomes owing to insufficient insulin secretion and/or insulin effect defect. It is critical to investigate new therapeutic approaches for T2DM and alternative, natural agents that target molecules in potential signal pathways. Medicinal plants are significant resources in the research of alternative new drug active ingredients. Bolanthus spergulifolius (B. spergulifolius)is one of the generaof the family Caryophyllaceae. In this study,it was explored the potentialanti-diabetic effects in vitroof B. spergulifolius extractson 3T3-L1 adipocytes.The total phenolic contents (TPC) of methanolic (MeOH), ethyl acettate (EA) and aqueous extracts of B. spergulifoliuswere evaluated via Folin-Ciocateau. B. spergulifoliusextracts showing highly TPC (Aqueous&lt; MeOH&lt; EA) and their different concentrations were carried out on preadipocytes differentiated in to mature 3T3-L1 adipocytesto investigate their half-maximal (50%) inhibitory concentration (IC50) value by using Thiazolyl blue tetrazolium bromide (MTT) assay. The IC50 of MeOH, EA and Aqueous extracts were observed as 305.7 ± 5.583 µg/mL, 567.4 ± 3.008 µg/mL, and 418.3 ± 4.390 µg/mL and used for further experiments.A live/dead assay further confirmed the cytotoxic effects of MeOH, EA and Aqueous extracts(respectively, 69.75 ± 1.70%, 61.75 ± 1.70%, 70 ± 4.24%, and for all p&lt; 0.05). Also, effects of extracts on lipid accumulation in mature 3T3-L1 adipocyteswere evaluated by Oil-Red O staining assay. The extractseffectively decreasedlipid-accumulation compared to untreated adipocytes(for all p&lt; 0.05).Moreover, effect of extracts on apoptosis regulated by the Baxand Bcl-2was investigated by quantitative reverse transcription polymerase chain reaction (qRT-PCR).Theextractssignificantly induced apoptosis by up-regulating pro-apoptoticBaxexpression but down-regulatedanti-apoptoticBcl-2gene expression compared to untreated adipocytes(for all p&lt; 0.05).The Glut-4expression linked with insulin resistance was determined by qRT-PCR, Western-blot analysis, and immunofluorescence staining.In parallel, the expression of Glut-4 in adipocytes treated with extracts was significantlyhigher compared to untreated adipocytes(for all p&lt; 0.05). Extracts significantly suppressed cell migration after 30 h of wounding in a scratch-assay(for all p&lt; 0.05). Cell morphology and diameter were further evaluated by phase-contrast microscopy, scanning electron microscopy, Immunofluorescence with F-Actin and Giemsa staining. The adipocytes treated with extracts partially lost spherical morphology and showed smaller cell-diameter compared to untreated adipocytes (for all p&lt; 0.05). In conclusion, these results suggest thatextracts of B. spergulifoliuscause to an induce apoptosis, decrease lipid-accumulation, woundhealing, up-regulating Glut-4 level and might contribute to reducing of insulin-resistance in DM.
DOI: 10.6084/m9.figshare.14691294
title: wormsizer settings

description: this file holds the settings used by wormsizer software to analyze worm lengths.
DOI: 10.6084/m9.figshare.14691294.v1
title: wormsizer settings

description: this file holds the settings used by wormsizer software to analyze worm lengths.
DOI: 10.6084/m9.figshare.14691291
title: Positive Δ199Hg in lamprophyres evidence oceanic mercury recycled into the mantle

description: Raw data for: Positive Δ199Hg in lamprophyres evidence oceanic mercury recycled into the mantle<br>
DOI: 10.6084/m9.figshare.14691291.v1
title: Positive Δ199Hg in lamprophyres evidence oceanic mercury recycled into the mantle

description: Raw data for: Positive Δ199Hg in lamprophyres evidence oceanic mercury recycled into the mantle<br>
DOI: 10.5517/ccdc.csd.cc26k8sv
title: CCDC 2042397: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5517/ccdc.csd.cc26k8rt
title: CCDC 2042396: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5517/ccdc.csd.cc27kt0n
title: CCDC 2072691: Experimental Crystal Structure Determination

description: Related Article: Xiaomin Liu, Xingtao Wang, Taiyang Zhang, Yanfeng Miao, Zhixiao Qin, Yuetian Chen, Yixin Zhao|2021|Angew.Chem.,Int.Ed.|60|12351|doi:10.1002/anie.202102538
DOI: 10.5517/ccdc.csd.cc26k8nq
title: CCDC 2042393: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5517/ccdc.csd.cc26k8qs
title: CCDC 2042395: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5517/ccdc.csd.cc26k8pr
title: CCDC 2042394: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5517/ccdc.csd.cc25q637
title: CCDC 2017328: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5517/ccdc.csd.cc26k9wz
title: CCDC 2042431: Experimental Crystal Structure Determination

description: Related Article: Yating Wan, Jie Wang, Hua Shu, Benyuan Cheng, Zhiyu He, Peipei Wang, Tifeng Xia|2021|Inorg.Chem.|60|7345|doi:10.1021/acs.inorgchem.1c00502
DOI: 10.5066/p9d205vb
title: 30 year

description: These data no longer exist
DOI: 10.25919/5mv9-3j08
title: Ecoult-CSIRO UltraFlex advanced-lead-acid battery high-rate testing dataset

description: This data relates to CSIRO's testing of 3 Ecoult UltraFlex advanced-lead-acid battery energy storage systems, using solar and home load profiles to emulate real-life deployments. The tests ran for approx. two years, across 2015 & 2016. Testing was run to evaluate battery performance and degradation under real-life conditions. Data was stored at the battery module level and recorded every 10 seconds. Battery voltage and current was measured. (I think) files were saved daily, partly in CSV and partly in a proprietary binary format. Data was generated in real-time. Data includes three file types: - BatteryData - CSV data, format "Time, String, Battery, Voltage, Current, Temperature" - StringData - CSV data, format "Time, String, Voltage, Current, SOC, Min Voltage, Max Voltage, Min Temperature, Max Temperature" - HMILog - Test data showing HMI logs for system controller (data structure, CSV file columns) The data is owned by Ecoult.
DOI: 10.6084/m9.figshare.14691318.v1
title: Supplementary Data: A multiple genome alignment workflow shows the impact of masking and parameter tuning on alignment of functional regions in plants

description: This dataset includes all Supplementary Data for the preprint titled "A multiple genome alignment workflow shows the impact of masking and parameter tuning on alignment of functional regions in plants". The data predominantly consists of Excel spreadsheets describing summary statistics and metrics for alignments of plant genomes. <br>Full descriptive names of all enclosed files are listed below.<br>Supplementary Data S1. Repeat masking results for grass genomes using three masking methodsSupplementary Data S2. Alignment metrics for whole genome pairwise alignmentSupplementary Data S3. Alignment metrics for whole genome multiple alignmentSupplementary Data S4. List of genes in the Sorghum mini-genomeSupplementary Data S5. List of genes in the Oryza sativa mini-genomeSupplementary Data S6. Mini-genome alignment rates across speciesSupplementary Data S7. Multiple alignment summary metrics for 750 alignment parameters combinationsSupplementary Data S8. Alignment performance of high-performing parameters compared to the default parameters and the cactus alignerSupplementary Data S9. Genomic conservation scoring for multiple alignments generated with 750 alignment parameter combination compared to the default parameters Supplementary Data S10. Custom LAST penalty matrices based on substitution rates calculated from Z. mays transposon alignments<br>
DOI: 10.5281/zenodo.4825876
title: Extended RAM Legacy Stock Assessment Database version 4.494

description: Extended RAM Legacy Stock Assessment Database version 4.494 Please be aware that this ‘mdl’ ('model fits included') version 4.494 of the RAM Legacy Stock Assessment Database (RAMLDB) additionally includes data not contained in the assessments themselves, but generated from assessment data. Generated data are used to fill in gaps where possible, for example, if stock assessments do not include reference point estimates. Supplemented data include calculations from assessment values, conversions of biomass variables, and reference points estimated post-hoc with surplus production models. The ‘Documents’ folder includes documentation files on the methods used for these calculations, conversions and model fitting. When assessment data are available, they are used preferentially in all cases.<br> <br> Although we identify data that were supplemented from data that were derived from stock assessments, some collector variables in RAMLDB include both of these data sources (with assessment values preferred). We recommend that the average user does not use this 'mdl' version of RAMLDB because of the additional assumptions and calculations involved. Instead, to avoid confusion between assessment-derived values and supplemented values, we recommend using the ‘asmt’ ('assessment data only') version of RAMLDB version 4.494. This 'asmt' version (doi 10.5281/zenodo.4823686) is also available in our Zenodo repository: https://zenodo.org/communities/rlsadb/
DOI: 10.5281/zenodo.4825875
title: Extended RAM Legacy Stock Assessment Database version 4.494

description: Extended RAM Legacy Stock Assessment Database version 4.494 Please be aware that this ‘mdl’ ('model fits included') version 4.494 of the RAM Legacy Stock Assessment Database (RAMLDB) additionally includes data not contained in the assessments themselves, but generated from assessment data. Generated data are used to fill in gaps where possible, for example, if stock assessments do not include reference point estimates. Supplemented data include calculations from assessment values, conversions of biomass variables, and reference points estimated post-hoc with surplus production models. The ‘Documents’ folder includes documentation files on the methods used for these calculations, conversions and model fitting. When assessment data are available, they are used preferentially in all cases.<br> <br> Although we identify data that were supplemented from data that were derived from stock assessments, some collector variables in RAMLDB include both of these data sources (with assessment values preferred). We recommend that the average user does not use this 'mdl' version of RAMLDB because of the additional assumptions and calculations involved. Instead, to avoid confusion between assessment-derived values and supplemented values, we recommend using the ‘asmt’ ('assessment data only') version of RAMLDB version 4.494. This 'asmt' version (doi 10.5281/zenodo.4823686) is also available in our Zenodo repository: https://zenodo.org/communities/rlsadb/
DOI: 10.6084/m9.figshare.14691318.v2
title: Supplementary Data: A multiple genome alignment workflow shows the impact of masking and parameter tuning on alignment of functional regions in plants

description: This dataset includes all Supplementary Data for the preprint titled "A multiple genome alignment workflow shows the impact of masking and parameter tuning on alignment of functional regions in plants". The data predominantly consists of Excel spreadsheets describing summary statistics and metrics for alignments of plant genomes. <br>Full descriptive names of all enclosed files are listed below.<br>Supplementary Data S1. Repeat masking results for grass genomes using three masking methodsSupplementary Data S2. Alignment metrics for whole genome pairwise alignmentSupplementary Data S3. Alignment metrics for whole genome multiple alignmentSupplementary Data S4. List of genes in the Sorghum mini-genomeSupplementary Data S5. List of genes in the Oryza sativa mini-genomeSupplementary Data S6. Mini-genome alignment rates across speciesSupplementary Data S7. Multiple alignment summary metrics for 750 alignment parameters combinationsSupplementary Data S8. Alignment performance of high-performing parameters compared to the default parameters and the cactus alignerSupplementary Data S9. Genomic conservation scoring for multiple alignments generated with 750 alignment parameter combination compared to the default parameters Supplementary Data S10. Custom LAST penalty matrices based on substitution rates calculated from Z. mays transposon alignments<br>
DOI: 10.5281/zenodo.4708025
title: Differential expression of SEREX-defined antigens in colorectal cancer when comparing clinical features such as disease stage

description: Excel sheet with data generated through comparisons of gene expression of SEREX-defined antigens when comparing clinical features such as stage and grade using the GSE5206 dataset.
description: Data from GSE5206 was analysed to determine the level of expression of antigens identified by SEREX-studies in our group. The fold change in expression and p values for each comparison between normal vs tumour, cont letter, cont number, collection site, T stage, N stage, M stage, Dukes stage, Grade, AICC stage and recurrence type were examined.
description: {"references": ["Kaiser, S.; Park, Y.K.; Franklin, J.L.; Halberg, R.B.; Yu, M.; Jessen, W.J.; Freudenberg, J.; Chen, X.; Haigis, K.; Jegga, A.G., et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 2007, 8, R131, doi:10.1186/gb-2007-8-7-r131."]}
DOI: 10.5281/zenodo.4708024
title: Differential expression of SEREX-defined antigens in colorectal cancer when comparing clinical features such as disease stage

description: Excel sheet with data generated through comparisons of gene expression of SEREX-defined antigens when comparing clinical features such as stage and grade using the GSE5206 dataset.
description: Data from GSE5206 was analysed to determine the level of expression of antigens identified by SEREX-studies in our group. The fold change in expression and p values for each comparison between normal vs tumour, cont letter, cont number, collection site, T stage, N stage, M stage, Dukes stage, Grade, AICC stage and recurrence type were examined.
description: {"references": ["Kaiser, S.; Park, Y.K.; Franklin, J.L.; Halberg, R.B.; Yu, M.; Jessen, W.J.; Freudenberg, J.; Chen, X.; Haigis, K.; Jegga, A.G., et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 2007, 8, R131, doi:10.1186/gb-2007-8-7-r131."]}
DOI: 10.6084/m9.figshare.14691324.v1
title: Tabla 3 Estadísticos descriptivos áreas e indicadores del DigComp-PED.docx

description: <b> Estadísticos descriptivos áreas e indicadores del DigComp-PED</b><br>
DOI: 10.6084/m9.figshare.14691324
title: Tabla 3 Estadísticos descriptivos áreas e indicadores del DigComp-PED.docx

description: <b> Estadísticos descriptivos áreas e indicadores del DigComp-PED</b><br>
DOI: 10.6084/m9.figshare.14691348
title: Tabla 4. Nivel de la CD según establecimiento de origen

description: Tabla 4. Nivel de la CD según establecimiento de origen<br>
DOI: 10.6084/m9.figshare.14691348.v1
title: Tabla 4. Nivel de la CD según establecimiento de origen

description: Tabla 4. Nivel de la CD según establecimiento de origen<br>
DOI: 10.6084/m9.figshare.14691354.v1
title: Tabla 5 Nivel de la CD según universidad de acceso

description: Tabla 5. Nivel de la CD según universidad de acceso<br>
DOI: 10.6084/m9.figshare.14691354
title: Tabla 5 Nivel de la CD según universidad de acceso

description: Tabla 5. Nivel de la CD según universidad de acceso<br>
DOI: 10.25919/h1cz-dw05
title: TSG files contain PLS-scalars applied to the Eucla Basement hyperspectral drill core data

description: GSWA collected hyperspectral reflectance spectra from drill holes intersecting the Eucla Basement (FOR004, FOR010, FOR011, MAD002, MAD014, HDDH001) using a HyLogger3 located at GSWA’s drill core library in Carlisle, WA. A PLS-based approach was used to model three geochemical indices, including the Magnesium number (“Mg#”; Mg/(Mg+Fe)), Silica Calcium Iron Magnesium number (“SCFM”; SiO2/(SiO2+CaO+FeOtot+MgO)), and Aluminium saturation index (“ASI”; Al2O3/(Na2O+K2O+CaO)) from the hyperspectral data. The accompanying CSIRO report EP184011 provides a detailed description of applied processing methods using The Spectral Geologist (TSG) software, including the feature extraction scripts (base and Multiple Feature Extraction Method (MFEM) scripts), and Partial Least Squares (PLS) modelling of geochemistry.
DOI: 10.17632/98z56yy639.1
title: Data for: Factors influencing the payment of costs of converting oil- to CNG-fuelled cars in a market dominated by used-cars

description: row data
DOI: 10.18112/openneuro.ds003453.v1.0.2
title: Protecting the Aging Brain, Bolus-Study
DOI: 10.25919/cmxh-rt23
title: Parkes observations for project P1041 semester 2021APRS_01

description: We propose to carry out a long-term timing campaign of millisecond pulsars (MSPs) discovered in the Globular Cluster Omega Centauri. So far, we have discovered seven MSPs and obtained coherent timing solutions for five of them. Monthly observations with the Parkes Ultra-Wideband Low (UWL) receiver system are requested to time known pulsars and search for new pulsars. Long-term timing and polarisation observations of these MSPs will provide us a new way to (1) study the dynamics of the core and constrain the existence of any intermediate-mass black holes; (2) reveal the origin of Gamma-ray emission from the core and put stringent constraints on dark matter parameters; (3) study Galactic ionised medium and magnetic fields on parsec scales.
DOI: 10.25919/s46h-h867
title: Parkes observations for project P885 semester 2021APRS_07

description: We propose to continue observing the magnetars 1E 1547.0-5408 and PSR J1622-4950 weekly, to track their rotation, flux density, and polarisation. The revolutionary UWL capabilities promise new opportunities to disentangle still mysterious radio emission mechanisms in magnetars. This promise is supported by the recent follow up of XTE J1810-197, again a radio magnetar after 10 years dormant, and of the hot-off-the-press magnetar Swift J1818.0-1607, for which our exciting recent results with UWL motivate an increased monitoring cadence to once weekly.
DOI: 10.25919/2g36-ze68
title: Parkes observations for project P885 semester 2021APRS_08

description: We propose to continue observing the magnetars 1E 1547.0-5408 and PSR J1622-4950 weekly, to track their rotation, flux density, and polarisation. The revolutionary UWL capabilities promise new opportunities to disentangle still mysterious radio emission mechanisms in magnetars. This promise is supported by the recent follow up of XTE J1810-197, again a radio magnetar after 10 years dormant, and of the hot-off-the-press magnetar Swift J1818.0-1607, for which our exciting recent results with UWL motivate an increased monitoring cadence to once weekly.
DOI: 10.25919/30n7-3t41
title: Parkes observations for project P960 semester 2021APRS_04

description: We aim to carry out receiver pointing and characterisation tests of Parkes receivers. Typically, these tests are carried out after the receiver package is installed, but time does not always allow for proper characterisation. Receivers for consideration include UWL, MARS, SX, K/KU-BAND and 13MM packages. In addition to cross-referencing C007 for flux calibration via pointing, we aim to conduct gain-elevation and system temperature experiments using the Moon, to ensure users of the Parkes Observatory have the most accurate information available for calibration purposes. We also wish to fully characterise the spectro-polarimetry response of the UWL, by determining the Mueller Matrix of the receiver.