cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5514112.v1
title: Supplementary Material for: Discrepancies between Perceived and Measured Cognition in Kidney Transplant Recipients: Implications for Clinical Management

description: <b><i>Background:</i></b> Cognitive impairment is common in kidney transplant (KT) recipients and affects quality of life, graft survival, morbidity, and mortality. Failure to identify patients with cognitive impairment can withhold appropriate and timely intervention. This study determines whether measured cognition with standard screening tools offers any advantage over perceived cognition in screening transplant patients for cognitive impairment. <b><i>Methods:</i></b> Cognition was assessed in 157 KT recipients using the Montreal Cognitive Assessment (MoCA; measured cognition). In addition, transplant physicians and nurse coordinators were asked to rate transplant recipients' level of cognition after routine clinical interactions (perceived cognition). Physicians and nurses were blind to MoCA scores. Perceived cognition scores were compared to MoCA scores. <b><i>Results:</i></b> Perceived cognition scores fairly correlated with MOCA scores (γ = 0.24, <i>p</i> = 0.001 for physicians and γ = 0.33, <i>p</i> &lt; 0.0001 for nurses). Physician scores moderately correlated with nurses scores (κ = 0.44, <i>p</i> &lt; 0.0001). Clinical perception had a low accuracy for identifying patients with cognitive impairment (sensitivity 66% for physicians, 65% for nurses), and those without cognitive impairment (specificity 67% for physicians, 76% for nurses). <b><i>Conclusion:</i></b> Clinical perception is inaccurate at detecting cognitive impairment in KT recipients. Objective tests should be considered to screen KT recipients for cognitive impairment.
DOI: 10.6084/m9.figshare.5514016
title: Supplementary Material for: Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model

description: Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss. Our results revealed that treatment with cisplatin upregulated the expression of active caspase-12 in cochlear cells, which is indicative of cisplatin-induced activation of ER-specific apoptosis. Increased expression of C/EBP homologous protein (CHOP) and cleaved caspase-9 suggested a close relationship between severe ER stress and mitochondria-dependent apoptosis in the cochlear cells of cisplatin-treated rats. In addition, we found that tauroursodeoxycholic acid (TUDCA), a promoter of ER proteostasis, had a protective effect on cisplatin-induced hearing loss. These results demonstrate that ER stress is involved in the cisplatin-induced apoptosis of cochlear cells in vivo.
DOI: 10.6084/m9.figshare.5514058.v1
title: Bruchophagus robiniae community.pdf

description: The parasitoid community of B. robiniae, seed-predator of black locust (Robinia pseudoacacia): e) Mesopolobus robiniae, f) Bracon sp. g) Baryscapus sp., h) Aprostocetus venustus, i) Pediobius bruchicida, j) Eupelmus urozonus
DOI: 10.6084/m9.figshare.5514037.v1
title: Supplementary Material for: Expression of Angiogenic and Inflammatory Factors in Choroidal Neovascularisation-Derived Retinal Pigment Epithelium

description: <b><i>Purpose:</i></b> Anti-angiogenic treatment is well established in the management of exudative age-related macular degeneration (AMD), but not sufficient in all patients. The characterisation of factors driving this chronic disease could serve to identify additional treatment options. The purpose of this study was to assess gene expression patterns and distinct changes in cells derived from surgically extracted choroidal neovascularisation (CNV) membranes. <b><i>Materials and Methods:</i></b> The expression of &gt;11,000 genes was analysed by means of a microarray in cells cultured from 2 late-stage CNV membranes compared to primary human retinal pigment epithelium (RPE) and ARPE-19 cells. A pathway analysis was performed to identify gene expression patterns associated with exudative AMD. <b><i>Results:</i></b> The analysis revealed significant alterations in gene sets associated with inflammatory processes in CNV-derived cells, involving the upregulation of pro-inflammatory factors IL6, C3, and C5, and downregulation of anti-inflammatory complement factor B and complement factor I. Factors associated with angiogenesis, such as VEGFA or ANGPT2, were not significantly regulated in the 2 RPE-derived cell lines. <b><i>Conclusion:</i></b> In late-stage CNV membrane-derived RPE, gene expression was shifted towards a pro-inflammatory state. Angiogenesis-associated factors were regulated differently in the 2 CNV-derived RPE membranes. While inflammation seems to be continuously stimulated by RPE associated with late exudative AMD, this appears not to be the case with regard to angioregulatory mechanisms.
DOI: 10.21954/ou.rd.5513647
title: Death and Dying Seminar: Material legacies: death, design and the digital (May 2017)

description: Seminar presentation by Dr Stacey Pitsillidies (University of Greenwich) about her doctoral research on creative work and material legacies around death and bereavement. The presentation was given on 16th May 2017 as part of the OU Death and Dying Seminar Series.
DOI: 10.21954/ou.rd.5513641
title: Death and Dying Seminar: Palliative care in the 21st century (June 2017)

description: Seminar presentation by Professor Scott Murray (University of Edinburgh) about videos illustrating dying trajectories, including multi-dimensional approaches to considering dying. Professor Murray shared the videos for feedback on content, the aim is for the videos to promote public conversations and anticipatory planning for care. The presentation was given on 20th June 2017 as part of the OU Death and Dying Seminar Series.
DOI: 10.6084/m9.figshare.5513623
title: Supplementary Material for: Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome

description: <b><i>Background/Aims:</i></b> Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, and it is usually characterized by chronic inflammation, oxidative stress, and altered microRNA expression. The aim of this study is to investigate how the effects of iridoids with genipin stem nucleus inhibit PCOS complications. The interactions between iridoids were investigated, as well. <b><i>Methods:</i></b> The chronic inflammation cell model was induced using lipopolysaccharide (LPS) in the RAW 264.7 and KGN cell lines. Levels of mRNA and protein expression were quantified using real time-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. The target of the iridoids was identified using the drug affinity responsive target stability (DARTS) method. The ability to scavenge free radicals was evaluated using the DPPH radical scavenging method and the ultra oxygen anion (O<sub>2</sub><sup>-</sup>) radical scavenging method. <b><i>Results:</i></b> The cells recovered from the inflammatory conditions and showed significantly decreased levels of interleukins after treatment with iridoids. The iridoids were demonstrated to target NF-κB, inhibit the phosphorylation and degradation of IκB, inhibit the nuclear entry of NF-κB, and inhibit the expression of inflammatory factors. Though only genipin showed an efficient ability to scavenge O<sub>2</sub><sup>-</sup>, the iridoids, IκB inhibitor (BAY 11-7085), and NF-κB inhibitor (PDTC) could inhibit LPS-induced oxidative stress on the cells, indicating that the iridoids exert their anti-oxidant effects via the NF-κB pathway. The expression levels of microRNAs (miRNAs) were also altered by LPS, but the iridoids could scarcely rescue the abnormal condition. <b><i>Conclusion:</i></b> Chronic inflammation may be an important incentive for oxidative stress and abnormal microRNA expression in PCOS, and iridoids can protect patients from inflammatory damage by regulating the NF-κB pathway.
DOI: 10.6084/m9.figshare.5513620
title: How workforce migrates in China: A perspective from social media

description: Weibo Data Description:<br>Tweets of Weibo during the Spring Festival travel rush, from January 13 to February 21 in 2017 are thoroughly collected to establish the migration network of workforce at the granularity of city.<br>Basic Statistics:<br>Number of cities: 371Number of city pairs(directed): 120,361Number of city pairs(undirected): 61,759Number of all flux: 41,454,268 <br>Data Format:<br>Each line in the file(WorkforceMigrate.csv) demonstrates a 12-tuple (city1,city2,flux,gdp1,gdp2,ave_gdp1,ave_gdp2,population1,population2,geographical_distance,travel_time,travel_distance) defined to denote workforce movement from city1 to city2. Details can be found as follows.<br>1. city1: origin city id2. city2: destination city id3. flux: number of movements from city1 to city24. gdp1: GDP of city15. gdp2: GDP of city26. avg_gdp1: the per capita GDP of city17. avg_gdp2: the per capita GDP of city28. population1: the number of permanent residents in city19. population2: the number of permanent residents in city210. geographical_distance: geographical distance between city1 and city211. travel_distance: travel distance from city1 to city2 provided by Baidu Map API12. travel_time: travel time from city1 to city2 provided by Baidu Map API<br>Data Description:<br>The demographic and economic information in 2015 are collected at the granularity of province.<br><br>Province Data Format:<br>Each line in file(ProvinceInfo.csv) demonstrates a 8-tuple (province, gdp15, Information Technology Industry,Financial Industry,Real Estate Industry,Scientific Research and Technical Services Industry,income15,R&D) defined to denote the economci information of provinces. Details can be found as follows:<br>1. province: province id2. gdp15: GDP of province3. Information Technology Industry: ratio of practitioner in the information technology industry4. Financial Industry: ratio of practitioner in the Financial industry5. Real Estate Industry: ratio of practitioner in the real estate industry 6. Scientific Research and Technical Services Industry: ratio of practitioner in the scientific research and technical services industry 7. income15: per capita disposable income8. R&D: the fund investment for research and development<br>Train Data Desciption:<br>The national railway line data, including 5,878 trains in total from train schedule are collected to establish the train network at the granularity of city.<br>Basic Statistics:<br>Number of cities: 284 citiesNumber of citi pairs(undirected): 12381<br>Data Format:Each line in the file(Train.csv) demonstrate a triple (city1, city2, train_count) defined to denote trains that pass through city1 and city2. Details can be found as follows:<br>1. city1: city id2. city2: city id3. train_count: the number of trains that pass through city1 and city2<br>Any issues please feel free to contact jichang@buaa.edu.cn.
DOI: 10.6084/m9.figshare.5513623.v1
title: Supplementary Material for: Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome

description: <b><i>Background/Aims:</i></b> Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, and it is usually characterized by chronic inflammation, oxidative stress, and altered microRNA expression. The aim of this study is to investigate how the effects of iridoids with genipin stem nucleus inhibit PCOS complications. The interactions between iridoids were investigated, as well. <b><i>Methods:</i></b> The chronic inflammation cell model was induced using lipopolysaccharide (LPS) in the RAW 264.7 and KGN cell lines. Levels of mRNA and protein expression were quantified using real time-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. The target of the iridoids was identified using the drug affinity responsive target stability (DARTS) method. The ability to scavenge free radicals was evaluated using the DPPH radical scavenging method and the ultra oxygen anion (O<sub>2</sub><sup>-</sup>) radical scavenging method. <b><i>Results:</i></b> The cells recovered from the inflammatory conditions and showed significantly decreased levels of interleukins after treatment with iridoids. The iridoids were demonstrated to target NF-κB, inhibit the phosphorylation and degradation of IκB, inhibit the nuclear entry of NF-κB, and inhibit the expression of inflammatory factors. Though only genipin showed an efficient ability to scavenge O<sub>2</sub><sup>-</sup>, the iridoids, IκB inhibitor (BAY 11-7085), and NF-κB inhibitor (PDTC) could inhibit LPS-induced oxidative stress on the cells, indicating that the iridoids exert their anti-oxidant effects via the NF-κB pathway. The expression levels of microRNAs (miRNAs) were also altered by LPS, but the iridoids could scarcely rescue the abnormal condition. <b><i>Conclusion:</i></b> Chronic inflammation may be an important incentive for oxidative stress and abnormal microRNA expression in PCOS, and iridoids can protect patients from inflammatory damage by regulating the NF-κB pathway.
DOI: 10.21954/ou.rd.5513605
title: Death and Dying Seminar: The use of sedation in dying patients (March 2017)

description: Seminar presentation by Dr Milind Arolker (Heart of England NHS Trust) about ethnographic research on using sedation near the end of life. The presentation was given on the 21st March 2017 as part of the OU Death and Dying Seminar Series.
DOI: 10.6084/m9.figshare.5513620.v1
title: How workforce migrates in China: A perspective from social media

description: Data Description:<br>Tweets of Weibo during the Spring Festival travel rush, from January 13 to February 21 in 2017 are thoroughly collected to establish the migration network of workforce at the granularity of city.<br>Basic Statistics:<br>Number of cities: 371Number of city pairs(directed): 120,361Number of city pairs(undirected): 61,759Number of all flux: 41,454,268 <br>Data Format:<br>Each line in the file(WorkforceMigrate.csv) demonstrates a 12-tuple (city1,city2,flux,gdp1,gdp2,ave_gdp1,ave_gdp2,population1,population2,geographical_distance,travel_time,travel_distance) defined to denote workforce movement from city1 to city2. Details can be found as follows.<br>1. city1: origin city id2. city2: destination city id3. flux: number of movements from city1 to city24. gdp1: GDP of city15. gdp2: GDP of city26. avg_gdp1: the per capita GDP of city17. avg_gdp2: the per capita GDP of city28. population1: the number of permanent residents in city19. population2: the number of permanent residents in city210. geographical_distance: geographical distance between city1 and city211. travel_distance: travel distance from city1 to city2 provided by Baidu Map API12. travel_time: travel time from city1 to city2 provided by Baidu Map API<br>Any issues please feel free to contact jichang@buaa.edu.cn.
DOI: 10.21954/ou.rd.5513590
title: Death and Dying Seminar: Death towards the beginning of life: stillbirth (April 2017)

description: Seminar presentation by Dr Dimitrios Siassakos (University of Bristol) on clinical research developing a pathway for stillbirth care. The seminar presentation was given on 18th April 2017 as part of the OU Death and Dying Seminar Series.
DOI: 10.6084/m9.figshare.5513575
title: Supplementary Material for "Learning Timed Automata via Genetic Programming"

description: Content:<br>- GUI demonstrator implementing genetic programming of timed automata<br>- readme-file describing the demonstrator<br>- Graphviz dot-files of all timed automata used for the evaluation
DOI: 10.21954/ou.rd.5513569
title: Death and Dying Seminar: Common or multiple futures for end of life care interventions around the world (January 2017)

description: Seminar presentation by Dr Shahaduz Zaman (University of Glasgow) about social science research and theoretical insights on end of life care interventions in an international context. The seminar was given on 18th January 2017 as part of the OU Death and Dying Seminar Series.
DOI: 10.6084/m9.figshare.5513557
title: Physiological patient data relating to HIV-infection, Antiretroviral treatment, Metabolic Syndrome and Large Artery Stiffness

description: This dataset consists of a single Excel spreadsheet containing anonymised patient data relating to physiology (including large elastic artery stiffness) and treatment details for HIV-1 infected patients being treated by combinations of antiretroviral therapy (cART). Participants were recruited from the Kilimanjaro Christian Medical Center (KCMC) in the Infectious Diseases Clinic (IDC) in northern Tanzania.<br>Sheet 2 of the spreadsheet also contains further analysis of the raw data in the 'subjects' sheet, including graphs.<br><b>Background</b>The study sample comprised of 102 subjects free of cardiovascular disease and major risk factors divided into two groups based on HIV-1 infection, treatment, and MS status: HIV-1<sup>+</sup>/cART<sup>+</sup>/MS<sup>+</sup> (n=12); HIV-1<sup>+</sup>/cART<sup>-</sup>/MS<sup>+</sup> (n=16); HIV-1<sup>-</sup>/ MS<sup>+</sup> (n=10); HIV-1<sup>+</sup>/cART<sup>+</sup>/MS<sup>-</sup> (n=42); HIV-1<sup>+</sup>/cART<sup>-</sup>/MS<sup>-</sup> (n=32); HIV-1<sup>-</sup>/ MS<sup>-</sup> (n=39). MS was established according the International Diabetes Federation definition. Large artery stiffness was assessed using applanation tonometry to determine aortic pulse wave velocity (aPWV) and aortic augmentation index at heart rate of 75 bpm (AIx@HR75). cART included lamivudine/zidovudine and nevirapine or efavirenz. <br>The study was approved by the Kilimanjaro Christian Medical University College (KCMUCo) Research Ethics Committee vide Ethical Clearance Certificate number 382.<br>All participants signed the informed consent form after reading the information sheet before including them in the study. In addition, they were made aware of the risks of de-identification for any research to which they contributed.<br>Specific consent for publication was not requested from participants because no directly-identifiable individual participant's data in any form, such as images, voice recordings or videos, are included in this manuscript.<br><br>
DOI: 10.6084/m9.figshare.5513548
title: Additional data for involved analysis

description: The item contains necessary data to reproduce analytical results in the manuscript.
DOI: 10.6084/m9.figshare.5513557.v1
title: Physiological patient data relating to HIV-infection, Antiretroviral treatment, Metabolic Syndrome and Large Artery Stiffness

description: This dataset consists of a single Excel spreadsheet containing anonymised patient data relating to physiology (including large elastic artery stiffness) and treatment details for HIV-1 infected patients being treated by combinations of antiretroviral therapy (cART). Participants were recruited from the Kilimanjaro Christian Medical Center (KCMC) in the Infectious Diseases Clinic (IDC) in northern Tanzania.<br>Sheet 2 of the spreadsheet also contains further analysis of the raw data in the 'subjects' sheet, including graphs.<br><b>Background</b>The study sample comprised of 102 subjects free of cardiovascular disease and major risk factors divided into two groups based on HIV-1 infection, treatment, and MS status: HIV-1<sup>+</sup>/cART<sup>+</sup>/MS<sup>+</sup> (n=12); HIV-1<sup>+</sup>/cART<sup>-</sup>/MS<sup>+</sup> (n=16); HIV-1<sup>-</sup>/ MS<sup>+</sup> (n=10); HIV-1<sup>+</sup>/cART<sup>+</sup>/MS<sup>-</sup> (n=42); HIV-1<sup>+</sup>/cART<sup>-</sup>/MS<sup>-</sup> (n=32); HIV-1<sup>-</sup>/ MS<sup>-</sup> (n=39). MS was established according the International Diabetes Federation definition. Large artery stiffness was assessed using applanation tonometry to determine aortic pulse wave velocity (aPWV) and aortic augmentation index at heart rate of 75 bpm (AIx@HR75). cART included lamivudine/zidovudine and nevirapine or efavirenz. <br>The study was approved by the Kilimanjaro Christian Medical University College (KCMUCo) Research Ethics Committee vide Ethical Clearance Certificate number 382.<br>All participants signed the informed consent form after reading the information sheet before including them in the study. In addition, they were made aware of the risks of de-identification for any research to which they contributed.<br>Specific consent for publication was not requested from participants because no directly-identifiable individual participant's data in any form, such as images, voice recordings or videos, are included in this manuscript.<br><br>
DOI: 10.6084/m9.figshare.5513530
title: DOI.xlsx

description: Dataset belonging to PLOS article PONE-D-17-11060R2 Ecosystem Services in European Protected Areas: Ambiguity in the Views of Scientists and Managers?
DOI: 10.6084/m9.figshare.5513533
title: Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells

description: Metastases, responsible for most of the solid tumor associated deaths, require angiogenesis and changes in endothelial cells. In this work, the effect of the secretomes of three breast tumor cell lines (MCF-7, MDA-MB-231 and ZR-75-30) on human umbilical vein endothelial cells (HUVEC) morphology was investigated. HUVEC treated with secretomes from breast cells were analyzed by confocal and time-lapse microscopy. Secretomes from ZR-75-30 and MDA-MB-231 cells modify the morphology and adhesion of HUVEC. These changes may provoke the loss of endothelial monolayer integrity. In consequence, tumor cells could have an increased access to circulation, which would then enhance metastasis.
DOI: 10.6084/m9.figshare.5513530.v1
title: DOI.xlsx

description: Dataset belonging to PLOS article PONE-D-17-11060R2 Ecosystem Services in European Protected Areas: Ambiguity in the Views of Scientists and Managers?
DOI: 10.6084/m9.figshare.5513533.v1
title: Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells

description: Metastases, responsible for most of the solid tumor associated deaths, require angiogenesis and changes in endothelial cells. In this work, the effect of the secretomes of three breast tumor cell lines (MCF-7, MDA-MB-231 and ZR-75-30) on human umbilical vein endothelial cells (HUVEC) morphology was investigated. HUVEC treated with secretomes from breast cells were analyzed by confocal and time-lapse microscopy. Secretomes from ZR-75-30 and MDA-MB-231 cells modify the morphology and adhesion of HUVEC. These changes may provoke the loss of endothelial monolayer integrity. In consequence, tumor cells could have an increased access to circulation, which would then enhance metastasis.
DOI: 10.6084/m9.figshare.5513548.v1
title: Additional data for involved analysis

description: The item contains necessary data to reproduce analytical results in the manuscript.
DOI: 10.6084/m9.figshare.5513548.v2
title: Additional data for involved analysis

description: The item contains necessary data to reproduce analytical results in the manuscript.
DOI: 10.6084/m9.figshare.5513548.v3
title: Additional data for involved analysis

description: The item contains necessary data to reproduce analytical results in the manuscript.