cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11610117.v1
title: Integrative Approach Based on Leaf Spray Mass Spectrometry, HPLC-DAD-MS/MS, and NMR for Comprehensive Characterization of Isoquinoline-Derived Alkaloids in Leaves of Onychopetalum amazonicum R. E. Fr.

description: Onychopetalum is an Amazonian botanical genus close-related with Bocageopsis and Unonopsis, whose species are used in traditional medicine. Although these genera are widely investigated from the phytochemical viewpoint, the knowledge about Onychopetalum remains almost unexplored. In order to perform a comprehensive characterization of isoquinoline-derived alkaloids from Onychopetalum amazonicum, an integrative approach based on the alkaloid profile analysis by leaf spray mass spectrometry (LS-MS), followed by a robust dereplication through high-performance liquid chromatography coupled with diode array detector and atmospheric pressure chemical ionization tandem mass spectrometry, (HPLC-DAD-APCI-MS/MS) and nuclear magnetic resonance (NMR) analysis was adopted. LS-MS allowed the tentative identification of reticuline, norjuziphine, nornuciferine, O-methylisopiline, nuciferine, N-methyl-O-methylisopiline, anonaine, and N-methylanonaine. HPLC-DAD-MS/MS analysis supported the tentative identification of N-methylasimilobine, asimilobine, norushinsunine, N-methylisopiline, isopiline, liriodenine, and lysicamine. Moreover, the integration of MS and NMR data allowed the additional identification of stepholidine and isocorypalmine. The applied integrative approach proposed herein enabled a comprehensive analysis of the alkaloid content from the O. amazonicum, showing to be a useful strategy for the dereplication of isoquinoline-derived alkaloids.
DOI: 10.6084/m9.figshare.11610048
title: Applications of the Dixon technique in the evaluation of the musculoskeletal system

description: Abstract The acquisition of images with suppression of the fat signal is very useful in clinical practice and can be achieved in a variety of sequences. The Dixon technique, unlike other fat suppression techniques, allows the signal of fat to be suppressed in the postprocessing rather than during acquisition, as well as allowing the visualization of maps showing the distribution of water and fat. This review of the Dixon technique aims to illustrate the basic physical principles, to compare the technique with other magnetic resonance imaging sequences for fat suppression or fat quantification, and to describe its applications in the study of diseases of the musculoskeletal system. Many variants of the Dixon technique have been developed, providing more consistent separation of the fat and water signals, as well as allowing correction for many confounding factors. It allows homogeneous fat suppression, being able to be acquired in combination with several other sequences, as well as with different weightings. The technique also makes it possible to obtain images with and without fat suppression from a single acquisition. In addition, the Dixon technique can be used as a quantitative method, allowing the proportion of tissue fat to be determined, and, in more updated versions, can quantify tissue iron.
DOI: 10.6084/m9.figshare.11610054
title: Effect of Suture on Mechanical Properties of Stitched Thermal Protection Sandwich

description: This paper investigates the tensile properties and bending performances of stitched thermal protection structure in engineering, and the effect of stitching density on mechanical properties, via a model of ceramic-aerogel stitched sandwich. With the help of ANSYS, titanium alloy bottom plate was added to the bottom surface of the thermal protection structure, which was regarded as the protected body, and the two were synergistically deformed. The validity of the entire model was verified. The distribution of stress field inside the structure was determined by substructure precise analysis method and the law of the finite element solution was given. The results show that interlaminar performance of the stitched sandwich is improved by 30% on average under tensile or four-point bending conditions.
DOI: 10.6084/m9.figshare.11610048.v1
title: Applications of the Dixon technique in the evaluation of the musculoskeletal system

description: Abstract The acquisition of images with suppression of the fat signal is very useful in clinical practice and can be achieved in a variety of sequences. The Dixon technique, unlike other fat suppression techniques, allows the signal of fat to be suppressed in the postprocessing rather than during acquisition, as well as allowing the visualization of maps showing the distribution of water and fat. This review of the Dixon technique aims to illustrate the basic physical principles, to compare the technique with other magnetic resonance imaging sequences for fat suppression or fat quantification, and to describe its applications in the study of diseases of the musculoskeletal system. Many variants of the Dixon technique have been developed, providing more consistent separation of the fat and water signals, as well as allowing correction for many confounding factors. It allows homogeneous fat suppression, being able to be acquired in combination with several other sequences, as well as with different weightings. The technique also makes it possible to obtain images with and without fat suppression from a single acquisition. In addition, the Dixon technique can be used as a quantitative method, allowing the proportion of tissue fat to be determined, and, in more updated versions, can quantify tissue iron.
DOI: 10.6084/m9.figshare.11610054.v1
title: Effect of Suture on Mechanical Properties of Stitched Thermal Protection Sandwich

description: This paper investigates the tensile properties and bending performances of stitched thermal protection structure in engineering, and the effect of stitching density on mechanical properties, via a model of ceramic-aerogel stitched sandwich. With the help of ANSYS, titanium alloy bottom plate was added to the bottom surface of the thermal protection structure, which was regarded as the protected body, and the two were synergistically deformed. The validity of the entire model was verified. The distribution of stress field inside the structure was determined by substructure precise analysis method and the law of the finite element solution was given. The results show that interlaminar performance of the stitched sandwich is improved by 30% on average under tensile or four-point bending conditions.
DOI: 10.6084/m9.figshare.11610042
title: New Proposal for Sugarcane Vinasse Treatment by Hydrothermal Carbonization: An Evaluation of Solid and Liquid Products

description: Vinasse is a residue of ethanol production from sugarcane. In view of the problems associated with its disposal, this study aimed to propose a treatment for vinasse by hydrothermal carbonization. The influence of temperature (100 to 200 ºC), acidity (1.7 to 8.3%) and reaction time (12 to 48 h) on the hydrothermal treatment was evaluated, as well the characteristics of the solid (hydrochar) and liquid (process water) products. For the solid product, two hydrothermal carbonization conditions stood out as leading to higher carbonization and yields. These conditions were 200 ºC, 8.3% acidity and times of 12 and 48 h. For the process water, the carbonization reaction at 200 ºC, 8.3% acidity and 48 h produced the highest discoloration and 77% reduction of total organic carbon. Thus, hydrothermal carbonization proved to be an efficient method to treat vinasse, and the hydrochar presents potential for use as fertilizers / soil conditioners, and also the process water after pre-treatment.
DOI: 10.6084/m9.figshare.11610039
title: Building Spaces of Social Interaction from Coworking Relationships and Practices

description: ABSTRACT Coworking spaces are work environments that have spread quickly in recent years and might be seen as a new work model. The purpose of this article was to analyze coworking practices and relationships in order to better understand how they occur and how they contribute to building spaces of social interaction. To explore this question, a unique and in-depth case study was conducted. Data were collected using techniques of ethnographic inspiration, including intense participant observation, semi-structured interviews and documentary analysis. The field study lasted 25 days and 40 associates were interviewed. The results show three levels of relationship that support a workspace that goes beyond ‘sharing’. At each level, practices to construct a space of social interaction were identified: self-management practices, cooperative business practices and community practices. Finally, we call for a reflection of a better understanding on what a social space within a coworking really means.
DOI: 10.6084/m9.figshare.11610039.v1
title: Building Spaces of Social Interaction from Coworking Relationships and Practices

description: ABSTRACT Coworking spaces are work environments that have spread quickly in recent years and might be seen as a new work model. The purpose of this article was to analyze coworking practices and relationships in order to better understand how they occur and how they contribute to building spaces of social interaction. To explore this question, a unique and in-depth case study was conducted. Data were collected using techniques of ethnographic inspiration, including intense participant observation, semi-structured interviews and documentary analysis. The field study lasted 25 days and 40 associates were interviewed. The results show three levels of relationship that support a workspace that goes beyond ‘sharing’. At each level, practices to construct a space of social interaction were identified: self-management practices, cooperative business practices and community practices. Finally, we call for a reflection of a better understanding on what a social space within a coworking really means.
DOI: 10.6084/m9.figshare.11610042.v1
title: New Proposal for Sugarcane Vinasse Treatment by Hydrothermal Carbonization: An Evaluation of Solid and Liquid Products

description: Vinasse is a residue of ethanol production from sugarcane. In view of the problems associated with its disposal, this study aimed to propose a treatment for vinasse by hydrothermal carbonization. The influence of temperature (100 to 200 ºC), acidity (1.7 to 8.3%) and reaction time (12 to 48 h) on the hydrothermal treatment was evaluated, as well the characteristics of the solid (hydrochar) and liquid (process water) products. For the solid product, two hydrothermal carbonization conditions stood out as leading to higher carbonization and yields. These conditions were 200 ºC, 8.3% acidity and times of 12 and 48 h. For the process water, the carbonization reaction at 200 ºC, 8.3% acidity and 48 h produced the highest discoloration and 77% reduction of total organic carbon. Thus, hydrothermal carbonization proved to be an efficient method to treat vinasse, and the hydrochar presents potential for use as fertilizers / soil conditioners, and also the process water after pre-treatment.
DOI: 10.6084/m9.figshare.11610036
title: RNA editing in the chloroplast of Asian Palmyra palm (Borassus flabellifer)

description: Abstract We have identified 46 RNA editing sites located in 20 chloroplast (cp) genes of Borassus flabellifer (Asian Palmyra palm), family Arecaceae, and tested these genes for supporting phylogenetic study among the commelinids. Among the 46 sites, 43 sites were found to cause amino acid alterations, which were predicted to increase the hydrophobicity and transmembrane regions of the proteins, and one site was to cause a premature stop codon. Analysis of these editing sites with data obtained from seed plants showed that a number of shared-editing sites depend on the evolutionary relationship between plants. We reconstructed a deep phylogenetic relationship among the commelinids using seven RNA edited genes that are orthologous among monocots. This tree could represent the relationship among subfamilies of Arecaceae family, but was insufficient to represent the relationship among the orders of the commelinid. After adding eight gene sequences with high parsimony-informative characters (PICs), the tree topology was improved and could support the topology for the commelinid orders ((Arecales,Dasypogenaceae) (Zingiberales+Commelinales,Poales)). The result provides support for inherent RNA editing along the evolution of seed plants, and we provide an alternative set of loci for the phylogenetic tree reconstruction of Arecaceae’s subfamilies.
DOI: 10.6084/m9.figshare.11610018
title: MAXIMIZATION OF ESSENTIAL OIL ANTIOXIDANT CAPACITY VIA STAR ANISE HYDRODISTILLATION

description: Abstract Chinese star anise essential oil (EO) is prized for its pleasant aroma and mainly due to its antioxidant capacity (AC), which can combat cancer and treat neurodegenerative diseases. This study shows the innovative approach of optimizing not only EO yield, but also to therapeutic activity. The product obtained follows the principle of the Pure Food and Drug Act and of eco-friendly technology. Also, the best analytical control methodology of the active principle during industrial production was also defined. The AC was found to be dependent on the extraction conditions, and the best antioxidant performance was reported after 3h of hydrodistillation time, using 500 mL distilled water and 8% dry fruits whose granulometry was inferior to 425 μm. Although all four analytical methodologies used for assessing AC are precise, they cannot be correlated. The antioxidant potential was 59.6±1.1 mg GAE/g EO for TP; 14.3±0.5 mmol TEAC/g EO for FRAP; 25.7±0.8 mmol TEAC/g EO for ABTS and 23.5±0.3 mmol TEAC/g EO for DPPH. The EO exhibited better AC than the trans-anethole and D-limonene standards, suggesting a positive synergistic effect. The DPPH method exhibited a good coefficient of determination (R²=0.9311) and has the advantage of using a solvent compatible with the EO.
DOI: 10.6084/m9.figshare.11610036.v1
title: RNA editing in the chloroplast of Asian Palmyra palm (Borassus flabellifer)

description: Abstract We have identified 46 RNA editing sites located in 20 chloroplast (cp) genes of Borassus flabellifer (Asian Palmyra palm), family Arecaceae, and tested these genes for supporting phylogenetic study among the commelinids. Among the 46 sites, 43 sites were found to cause amino acid alterations, which were predicted to increase the hydrophobicity and transmembrane regions of the proteins, and one site was to cause a premature stop codon. Analysis of these editing sites with data obtained from seed plants showed that a number of shared-editing sites depend on the evolutionary relationship between plants. We reconstructed a deep phylogenetic relationship among the commelinids using seven RNA edited genes that are orthologous among monocots. This tree could represent the relationship among subfamilies of Arecaceae family, but was insufficient to represent the relationship among the orders of the commelinid. After adding eight gene sequences with high parsimony-informative characters (PICs), the tree topology was improved and could support the topology for the commelinid orders ((Arecales,Dasypogenaceae) (Zingiberales+Commelinales,Poales)). The result provides support for inherent RNA editing along the evolution of seed plants, and we provide an alternative set of loci for the phylogenetic tree reconstruction of Arecaceae’s subfamilies.
DOI: 10.6084/m9.figshare.11610018.v1
title: MAXIMIZATION OF ESSENTIAL OIL ANTIOXIDANT CAPACITY VIA STAR ANISE HYDRODISTILLATION

description: Abstract Chinese star anise essential oil (EO) is prized for its pleasant aroma and mainly due to its antioxidant capacity (AC), which can combat cancer and treat neurodegenerative diseases. This study shows the innovative approach of optimizing not only EO yield, but also to therapeutic activity. The product obtained follows the principle of the Pure Food and Drug Act and of eco-friendly technology. Also, the best analytical control methodology of the active principle during industrial production was also defined. The AC was found to be dependent on the extraction conditions, and the best antioxidant performance was reported after 3h of hydrodistillation time, using 500 mL distilled water and 8% dry fruits whose granulometry was inferior to 425 μm. Although all four analytical methodologies used for assessing AC are precise, they cannot be correlated. The antioxidant potential was 59.6±1.1 mg GAE/g EO for TP; 14.3±0.5 mmol TEAC/g EO for FRAP; 25.7±0.8 mmol TEAC/g EO for ABTS and 23.5±0.3 mmol TEAC/g EO for DPPH. The EO exhibited better AC than the trans-anethole and D-limonene standards, suggesting a positive synergistic effect. The DPPH method exhibited a good coefficient of determination (R²=0.9311) and has the advantage of using a solvent compatible with the EO.
DOI: 10.6084/m9.figshare.11610012
title: Low birth weight in a subnormal urban cluster under Family Health Strategy’s care

description: Abstract Objectives: to identify the prevalence and to analyze the factors associated with low birth weight in a subnormal urban cluster in Pernambuco under Family Health Strategy’s care. Methods: a cross-sectional study with a census sample carried out between July and October in 2015. The variables studied were age and years of maternal schooling, social status, housing, water supply, waste disposal, prenatal care, alcohol consumption and cigarette smoking during pregnancy, along with gender, birth weight and prematurity. Stata 12.1 was utilized in order to understand the factors associated with low birth weight through uni-and-multivariate Poisson analysis, adjusted and gross prevalence ratios, composing a final statistical model considering p value &lt;0.05 for statistical significance. Results: regarding the 294 children the LBW prevalence was 12.2% (CI95% = 8.7-16.5). Children whose mothers reported drinking during pregnancy were 2.78 times more at risk of being born with low birth weight (p&lt;0.001) when compared with children whose mothers did not report this practice in gestation. Conclusions: the study evidenced the relevance maternal habits bears in the newborns’ health.
DOI: 10.6084/m9.figshare.11610003
title: Non-random distribution of microsatellite motifs and (TTAGGG)n repeats in the monkey frog Pithecopus rusticus (Anura, Phyllomedusidae) karyotype

description: Abstract The monkey frog, Pithecopus rusticus (Anura, Phyllomedusidae) is endemic to the grasslands of the Araucarias Plateau, southern Brazil. This species is known only from a small population found at the type locality. Here, we analyzed for the first time the chromosomal organization of the repetitive sequences, including seven microsatellite repeats and telomeric sequences (TTAGGG)n in the karyotype of the species by Fluorescence in situ Hybridization. The dinucleotide motifs had a pattern of distribution clearly distinct from those of the tri- and tetranucleotides. The dinucleotide motifs are abundant and widely distributed in the chromosomes, located primarily in the subterminal regions. The tri- and tetranucleotides, by contrast, tend to be clustered, with signals being observed together in the secondary constriction of the homologs of pair 9, which are associated with the nucleolus organizer region. As expected, the (TTAGGG)n probe was hybridized in all the telomeres, with hybridization signals being detected in the interstitial regions of some chromosome pairs. We demonstrated the variation in the abundance and distribution of the different microsatellite motifs and revealed their non-random distribution in the karyotype of P. rusticus. These data contribute to understand the role of repetitive sequences in the karyotype diversification and evolution of this taxon.
DOI: 10.6084/m9.figshare.11610012.v1
title: Low birth weight in a subnormal urban cluster under Family Health Strategy’s care

description: Abstract Objectives: to identify the prevalence and to analyze the factors associated with low birth weight in a subnormal urban cluster in Pernambuco under Family Health Strategy’s care. Methods: a cross-sectional study with a census sample carried out between July and October in 2015. The variables studied were age and years of maternal schooling, social status, housing, water supply, waste disposal, prenatal care, alcohol consumption and cigarette smoking during pregnancy, along with gender, birth weight and prematurity. Stata 12.1 was utilized in order to understand the factors associated with low birth weight through uni-and-multivariate Poisson analysis, adjusted and gross prevalence ratios, composing a final statistical model considering p value &lt;0.05 for statistical significance. Results: regarding the 294 children the LBW prevalence was 12.2% (CI95% = 8.7-16.5). Children whose mothers reported drinking during pregnancy were 2.78 times more at risk of being born with low birth weight (p&lt;0.001) when compared with children whose mothers did not report this practice in gestation. Conclusions: the study evidenced the relevance maternal habits bears in the newborns’ health.
DOI: 10.6084/m9.figshare.11610003.v1
title: Non-random distribution of microsatellite motifs and (TTAGGG)n repeats in the monkey frog Pithecopus rusticus (Anura, Phyllomedusidae) karyotype

description: Abstract The monkey frog, Pithecopus rusticus (Anura, Phyllomedusidae) is endemic to the grasslands of the Araucarias Plateau, southern Brazil. This species is known only from a small population found at the type locality. Here, we analyzed for the first time the chromosomal organization of the repetitive sequences, including seven microsatellite repeats and telomeric sequences (TTAGGG)n in the karyotype of the species by Fluorescence in situ Hybridization. The dinucleotide motifs had a pattern of distribution clearly distinct from those of the tri- and tetranucleotides. The dinucleotide motifs are abundant and widely distributed in the chromosomes, located primarily in the subterminal regions. The tri- and tetranucleotides, by contrast, tend to be clustered, with signals being observed together in the secondary constriction of the homologs of pair 9, which are associated with the nucleolus organizer region. As expected, the (TTAGGG)n probe was hybridized in all the telomeres, with hybridization signals being detected in the interstitial regions of some chromosome pairs. We demonstrated the variation in the abundance and distribution of the different microsatellite motifs and revealed their non-random distribution in the karyotype of P. rusticus. These data contribute to understand the role of repetitive sequences in the karyotype diversification and evolution of this taxon.
DOI: 10.6084/m9.figshare.12864580.v1
title: Additional file 1 of The CanMoRe trial – evaluating the effects of an exercise intervention after robotic-assisted radical cystectomy for urinary bladder cancer: the study protocol of a randomised controlled trial

description: Additional file 1. Exercise programme.
DOI: 10.6084/m9.figshare.11609994
title: Communication of bad news in palliative care within pediatric oncology

description: Abstract The study aims to understand the process of communicating bad news experienced by families of patients in hospice care from the pediatric oncology reference center in Fortaleza, Ceará, Brazil. This is a qualitative descriptive study using structured interviews with families of children and adolescents in palliative care and guided by thematic and categorical content analysis. It was observed that, in the view of family members, communication brings ambivalent reactions, involving the need to know and the suffering caused by the prospect of the child’s death. Humanizing factors, such as an empathic stance, welcoming attitude and affection related to the others’ suffering experience, resonate in the good relationship between professionals and family members. It is concluded that the communication in palliative care is an imperative in everyday pediatric oncology and causes suffering that requires mental health care. Thus, professional practice needs constant improvement in order to qualify the services of palliative care.