cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.1219207
title: Characterizing Nsd3 Amplification In Lung Cancer

description: <strong>SGC Open Notebook Project to Characterize the HMTase NSD3</strong>

<strong>Exp020 Objective: </strong>NSD3 (WHSC1L1) is amplified in ~5% of Non-Small Cell Lung Cancer patients( cBioPortal : Cerami et<br>
al. Cancer Discov. 2012 and Gao et al. Sci. Signal. 2013). However, the implications of this event on the<br>
formation and progression of the disease are unclear. While NSD3 may be a driver of lung cancer, it is also<br>
plausible that this locus is simply amplified at a higher frequency in the context of cancer-associated genomic<br>
instability. To dive deeper into this question I will use The Cancer Genome Atlas (TCGA) lung cancer<br>
data-sets to look for associations between NSD3 amplification and mutational status as well as gene expression<br>
profiles. This data has been generated by the TCGA Research Network: http://cancergenome.nih.gov/. I<br>
hypothesize that if NSD3 amplification is a driving force in a subset of lung tumors, these samples will share<br>
similar gene expression profiles and exhibit higher expression levels of NSD3. Here, I am using FirebrowserR<br>
(Deng M., et al. Database. 2017 - PMID:28062517), an R client for Broad Institute’s Firehose Web API,<br>
which allows TCGA data processed by the Firehose Pipeline to be directly imported into R for analysis.
description: Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
DOI: 10.5281/zenodo.1219208
title: Characterizing Nsd3 Amplification In Lung Cancer

description: <strong>SGC Open Notebook Project to Characterize the HMTase NSD3</strong>

<strong>Exp020 Objective: </strong>NSD3 (WHSC1L1) is amplified in ~5% of Non-Small Cell Lung Cancer patients( cBioPortal : Cerami et<br>
al. Cancer Discov. 2012 and Gao et al. Sci. Signal. 2013). However, the implications of this event on the<br>
formation and progression of the disease are unclear. While NSD3 may be a driver of lung cancer, it is also<br>
plausible that this locus is simply amplified at a higher frequency in the context of cancer-associated genomic<br>
instability. To dive deeper into this question I will use The Cancer Genome Atlas (TCGA) lung cancer<br>
data-sets to look for associations between NSD3 amplification and mutational status as well as gene expression<br>
profiles. This data has been generated by the TCGA Research Network: http://cancergenome.nih.gov/. I<br>
hypothesize that if NSD3 amplification is a driving force in a subset of lung tumors, these samples will share<br>
similar gene expression profiles and exhibit higher expression levels of NSD3. Here, I am using FirebrowserR<br>
(Deng M., et al. Database. 2017 - PMID:28062517), an R client for Broad Institute’s Firehose Web API,<br>
which allows TCGA data processed by the Firehose Pipeline to be directly imported into R for analysis.
description: Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
DOI: 10.15139/s3/b9jxj4
title: Monmouth University National Poll, Number 141
DOI: 10.5281/zenodo.1209170
title: Pleckstrin Homology Domain Interacting Protein (Phip); A Target Enabling Package

description: SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
description: The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].
DOI: 10.5281/zenodo.1209171
title: Pleckstrin Homology Domain Interacting Protein (Phip); A Target Enabling Package

description: SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
description: The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].
DOI: 10.5284/1047198
title: 13 Gilbury Close, Swaythling, Southampton, Hampshire. Archaeological Evaluation (SOU1717) (OASIS ID: wessexar1-257617)

description: Wessex Archaeology was commissioned by Radian Group - Eastleigh to carry out an archaeological evaluation on land at 13 Gilbury Close, Swaythling, Southampton, Hampshire (NGR 483834 105348). The fieldwork was carried out on the 13th of July 2016. A total of two trial trenches were excavated, a 5% sample of the proposed development area, in order to investigate the archaeological potential of the site. Trench 5 was targeted on a potential out building of a post-medieval farm complex identified through maps of the area, although no evidence for this feature was identified.
DOI: 10.5523/bris.2fceiuzvtolvl2jd1ll285tzrz
title: Data from Negative Electron Affinity arising from Aluminium on the Diamond (100) Surface

description: This is the data repository for the paper 'Negative Electron Affinity arising from Aluminium on the Diamond (100) Surface: A Theoretical Study' by Michael C. James, Alex Croot, Paul W. May and Neil L. Allan.  J. Phys. Cond. Matter (2018)
DOI: 10.5281/zenodo.1215526
title: Human Histone Deacetylase 6 (Hdac6); A Target Enabling Package

description: HDAC6 is a cytosolic deacetylase with diverse roles in cellular trafficking, autophagy and cell signalling. Specifically targeting the unique zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 may be an attractive strategy in myeloma and lymphoma but no inhibitor has been reported to date. Presented here are 4 co-crystal structures of HDAC6 ZnF-UBD in complex with different compounds, and associated SPR, ITC and FP assays.
description: This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
DOI: 10.5281/zenodo.1215530
title: Human Set Domain Bifurcated 1 (Setdb1), Tudor Domain; A Target Enabling Package

description: SETDB1 is a H3K9 methyltransferase involved in transcriptional silencing with a catalytic SET domain and a triple Tudor domain containing a methyl-lysine binding site. SGC Toronto previously solved the apo structure of the Tudor domain (PDB code 3DLM). Amplification of SETDB1 in over 15% lung adenocarcinoma correlates with high mRNA and protein levels and its depletion in SETDB1-amplified cells reduces cancer growth in cell culture and nude mice models, whereas its overexpression increases tumour invasiveness (Rodriguez-Paredes et al. Oncogene 2014, Shah et al. Epigenetic Chromatin 2014). Several histone methyltransferases are known to have non-catalytic functions that might be alternative targeting strategies. For instance, recognition of H3K9 methylation by the ankyrin repeat of the methyltransferase GLP is required for efficient establishment of H3K9 methylation (Liu et al. Genes Dev. 2015). No catalytic domain inhibitor of SETDB1 has been reported to date. The goal of this TEP is to enable the discovery of potent, selective compounds targeting the Tudor domain of SETDB1.
description: This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
DOI: 10.5281/zenodo.1219621
title: A Canadian French Emotional Speech Dataset

description: The Canadian French Emotional (CaFE) speech dataset contains six different sentences, pronounced by six male and six female actors, in six basic emotions plus one neutral emotion. The six basic emotions are acted in two different intensities.

This dataset is freely available under a Creative Commons license (CC BY-NC-SA 4.0).

The dataset was digitally recorded at a high-resolution (192 kHz sampling rate, 24 bits per sample).

CaFE_192k_1.zip - CaFE Speech Dataset (Part 1)<br>
CaFE_192k_2.zip - CaFE Speech Dataset (Part 2)

A filtered and downsampled version at a lower resolution (48 kHz sampling rate, 16 bits per sample) is also available here:

CaFE_48k.zip - CaFE Speech Dataset at 48 kHz

This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

To view a copy of this license, visit Creative Commons

The dataset can also be downloaded from the Universite de Sherbrooke website

<strong>Note: This version 1.0 is now obsolete.</strong>
DOI: 10.5281/zenodo.1215529
title: Plasmodium Bromodomain Pfbdp4; A Target Enabling Package

description: There are 8 bromodomain-containing proteins in each annotated Plasmodium genome, with only one containing dual bromodomains (BRDs) – i.e. a total of 9 BRDs. In collaboration with SGC Oxford, we have expressed, purified and crystallized the BRDs in PfBDP1, PfBDP3, PfBDP4 (namely PfBDP4B) and PfGCN5. By screening all four against a focused BRD inhibitor library (SGC Oxford) using the DSF assay, we identified a small number of hits that were subsequently validated and quantitatively assessed using ITC. Two similar compounds with the dihydropteridinone scaffold, namely BI2536 and BI6727, stood out as potent inhibitors of PfBDP4B (both with Kd below 200 nM). We further collaborated with U of Melbourne to test them against Pf3D7 and found them capable of inhibiting blood stage development at sub-micromolar concentrations. Analysis of the co-structure of PfBDP4B+BI2536 suggests the possibility of increasing the potency and selectivity of inhibition.
description: This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
DOI: 10.5517/ccdc.csd.cc1pvq08
title: CCDC 1574800: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pvq19
title: CCDC 1574801: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pvq2b
title: CCDC 1574802: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pvq3c
title: CCDC 1574803: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pvq4d
title: CCDC 1574804: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pvq5f
title: CCDC 1574805: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1pvq6g
title: CCDC 1574806: Experimental Crystal Structure Determination

description: Related Article: Gonzalo Campillo-Alvarado, Eva C. Vargas-Olvera, Herbert Höpfl, Angel D. Herrera-España, Obdulia Sánchez-Guadarrama, Hugo Morales-Rojas, Leonard R. MacGillivray, Braulio Rodríguez-Molina, Norberto Farfán|2018|Cryst.Growth Des.|18|2726|doi:10.1021/acs.cgd.7b01368
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1yw0d7
title: CCDC 1813419: Experimental Crystal Structure Determination

description: Related Article: Zhuang Tian, Jiaojiao Xu, Bingxin Liu, Qitao Tan, Bin Xu|2018|Org.Lett.|20|2603|doi:10.1021/acs.orglett.8b00798
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1ndg8s
title: CCDC 1531315: Experimental Crystal Structure Determination

description: Related Article: Virginia San Nacianceno, Lourdes Ibarlucea, Claudio Mendicute-Fierro, Antonio Rodríguez-Diéguez, José M. Seco, Antonio J. Mota, María A. Garralda|2018|Inorg.Chem.|57|5307|doi:10.1021/acs.inorgchem.8b00320
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z05tz
title: CCDC 1817431: Experimental Crystal Structure Determination

description: Related Article: Hui Jiang, Ana Bellomo, Mengnan Zhang, Patrick J. Carroll, Brian C. Manor, Tiezheng Jia, Patrick J. Walsh|2018|Org.Lett.|20|2522|doi:10.1021/acs.orglett.8b00599
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z05v0
title: CCDC 1817432: Experimental Crystal Structure Determination

description: Related Article: Hui Jiang, Ana Bellomo, Mengnan Zhang, Patrick J. Carroll, Brian C. Manor, Tiezheng Jia, Patrick J. Walsh|2018|Org.Lett.|20|2522|doi:10.1021/acs.orglett.8b00599
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z1lf1
title: CCDC 1818783: Experimental Crystal Structure Determination

description: Related Article: Yonghong Guo, Yuhan Zhang, Mingxing Xiao, Zhixiang Xie|2018|Org.Lett.|20|2509|doi:10.1021/acs.orglett.8b00238
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1z1sd6
title: CCDC 1818968: Experimental Crystal Structure Determination

description: Related Article: Christopher M. Glinkerman, Dale L. Boger|2018|Org.Lett.|20|2628|doi:10.1021/acs.orglett.8b00825
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1znxn6
title: CCDC 1837359: Experimental Crystal Structure Determination

description: Related Article: Ekaterina M. Feklicheva, Victor B. Rybakov, Eugene V. Babaev|2018|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1zny4q
title: CCDC 1837374: Experimental Crystal Structure Determination

description: Related Article: Ekaterina M. Feklicheva, Victor B. Rybakov, Eugene V. Babaev|2018|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1znzn8
title: CCDC 1837421: Experimental Crystal Structure Determination

description: Related Article: Ekaterina M. Feklicheva, Victor    B. Rybakov, Eugene    V. Babaev|2018|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc1zp0f3
title: CCDC 1837445: Experimental Crystal Structure Determination

description: Related Article: Brian W. Skelton, Murray V. Baker, Rosenani A. Haque|2018|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.1219672
title: Argrelation

description: the dataset used in the paper "Argument Relation Classification Using a Joint Inference Model", Yufang Hou and Charles Jochim, the 4th argMining workshop@EMNLP 2017
DOI: 10.5281/zenodo.1219673
title: Argrelation

description: the dataset used in the paper "Argument Relation Classification Using a Joint Inference Model", Yufang Hou and Charles Jochim, the 4th argMining workshop@EMNLP 2017