cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28714680
title: Physiotherapist- and peer-led physical activity counseling for people with spinal cord injury: a cross-sectional study of barriers and facilitators to implementation in the rehabilitation to community transition

description: A large decrease in physical activity (PA) is typically observed among people with spinal cord injury (SCI) upon discharge from in-hospital rehabilitation. Physiotherapists and SCI peers are well-positioned to intervene at this critical timepoint; however,the implementation of coordinated PA interventions between these two groups have yet to be studied. To identify barriers and facilitators that affect the implementation of coordinated PA counseling among physiotherapists and SCI peers during the transition from in-hospital rehabilitation to the community. Semi-structured interviews were conducted with nine physiotherapists and two SCI peer coaches, using an interview guide informed by the Theoretical Domains Framework (TDF). Interviews were transcribed and coded deductively onto the TDF with themes and subthemes generated by inductive content analysis. The most salient TDF domains were social influences, environmental context and resources, and skills. Specifically, participants identified challenges such as addressing patient barriers and continual staff onboarding. Facilitators included the availability of peer coaches with lived experience, support from champions of the PA counseling intervention, group training sessions for physiotherapists and SCI peer coaches, and an adaptable PA counseling form as a conversation guide. Successful coordination of services provided during the transition from in-hospital rehabilitation to the community may be strengthened by 1) providing resources and training that guide both content and delivery of PA counseling and 2) a referral system that leverages the strengths of both physiotherapists and peer support.
DOI: 10.6084/m9.figshare.28714680.v1
title: Physiotherapist- and peer-led physical activity counseling for people with spinal cord injury: a cross-sectional study of barriers and facilitators to implementation in the rehabilitation to community transition

description: A large decrease in physical activity (PA) is typically observed among people with spinal cord injury (SCI) upon discharge from in-hospital rehabilitation. Physiotherapists and SCI peers are well-positioned to intervene at this critical timepoint; however,the implementation of coordinated PA interventions between these two groups have yet to be studied. To identify barriers and facilitators that affect the implementation of coordinated PA counseling among physiotherapists and SCI peers during the transition from in-hospital rehabilitation to the community. Semi-structured interviews were conducted with nine physiotherapists and two SCI peer coaches, using an interview guide informed by the Theoretical Domains Framework (TDF). Interviews were transcribed and coded deductively onto the TDF with themes and subthemes generated by inductive content analysis. The most salient TDF domains were social influences, environmental context and resources, and skills. Specifically, participants identified challenges such as addressing patient barriers and continual staff onboarding. Facilitators included the availability of peer coaches with lived experience, support from champions of the PA counseling intervention, group training sessions for physiotherapists and SCI peer coaches, and an adaptable PA counseling form as a conversation guide. Successful coordination of services provided during the transition from in-hospital rehabilitation to the community may be strengthened by 1) providing resources and training that guide both content and delivery of PA counseling and 2) a referral system that leverages the strengths of both physiotherapists and peer support.
DOI: 10.6084/m9.figshare.28540727
title: Cost of manual therapy for musculoskeletal disorders: a systematic review of systematic reviews with methodological and reporting quality

description: The purpose of this systematic review of systematic reviews was to determine the cost-effectiveness of manual therapy in the management of patients with musculoskeletal disorders, with an assessment of methodological and reporting quality. To be included, publications needed to be systematic reviews including studies with participants with musculoskeletal conditions &gt; 18 years old; the experimental intervention was manual therapy; assessed the cost of manual therapy; and were published in English. Literature, narrative, and scoping reviews were excluded. An electronic search was conducted in May 2024 using CINAHL (EBSCO Host), Ovid MEDLINE® ALL, the Cochrane Library, and Embase. The methodological and reporting quality of systematic reviews was assessed using A MeaSurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020). Cost data was reported narratively. AMSTAR 2 and PRISMA compliancewas summarized narratively and graphically. Eleven systematic reviews were included. Approximately half of the reviews on spine pain concluded that manual therapy and acupuncture were cost-effective compared to usual care. A limited number of systematic reviews on peripheral joint pain concluded that manual therapy was cost-effective for shoulder pain, but was inconclusive for ankle fractures and knee osteoarthritis. Confidence in the results of the included reviews was low to critically low. Compliance with PRISMA guidelines was highly variable. Overall low to critically low methodological quality, variability in reporting quality, and heterogeneity of cost data makes it difficult to draw summative conclusions about the cost-effectiveness of manual therapy for patients with musculoskeletal conditions.
DOI: 10.6084/m9.figshare.28540727.v1
title: Cost of manual therapy for musculoskeletal disorders: a systematic review of systematic reviews with methodological and reporting quality

description: The purpose of this systematic review of systematic reviews was to determine the cost-effectiveness of manual therapy in the management of patients with musculoskeletal disorders, with an assessment of methodological and reporting quality. To be included, publications needed to be systematic reviews including studies with participants with musculoskeletal conditions &gt; 18 years old; the experimental intervention was manual therapy; assessed the cost of manual therapy; and were published in English. Literature, narrative, and scoping reviews were excluded. An electronic search was conducted in May 2024 using CINAHL (EBSCO Host), Ovid MEDLINE® ALL, the Cochrane Library, and Embase. The methodological and reporting quality of systematic reviews was assessed using A MeaSurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020). Cost data was reported narratively. AMSTAR 2 and PRISMA compliancewas summarized narratively and graphically. Eleven systematic reviews were included. Approximately half of the reviews on spine pain concluded that manual therapy and acupuncture were cost-effective compared to usual care. A limited number of systematic reviews on peripheral joint pain concluded that manual therapy was cost-effective for shoulder pain, but was inconclusive for ankle fractures and knee osteoarthritis. Confidence in the results of the included reviews was low to critically low. Compliance with PRISMA guidelines was highly variable. Overall low to critically low methodological quality, variability in reporting quality, and heterogeneity of cost data makes it difficult to draw summative conclusions about the cost-effectiveness of manual therapy for patients with musculoskeletal conditions.
DOI: 10.6084/m9.figshare.29204697
title: Dual synergetic approach for targeting dysfunctional cells based on rare-earth-doped forsterite nanoparticles

description: In recent years, forsterite (Fo, Mg₂SiO₄) has emerged as a promising biomaterial for bone tissue engineering scaffolds, demonstrating efficacy in inhibiting the growth of clinical bacterial isolates. In addition, rare-earth (RE) doped Fo exhibits excitation properties that match the near-infrared (NIR) biological transparency window (700–1800 nm), facilitating deep penetration into biological tissues. Despite these advantageous properties, data on the toxicity of RE-doped forsterite is lacking, and effects on damaged or dysfunctional cells, such as cancer cells, are not known. The aim of this study was to examine the toxicity of RE-doped forsterite nanoparticles (NPs) in cultures of healthy and tumor skin cells. Specifically, forsterite doped with Er<sup>3+</sup>, Yb<sup>3+</sup>, and a combination of Er<sup>3+</sup>/Yb<sup>3+</sup>, produced via reverse strike coprecipitation (RSC), was employed in cytotoxicity assays. The influence of solution pH on the toxicity response was also investigated. Data demonstrated that all NPs exhibited biocompatibility with HaCaT keratinocytes, while melanoma B16-F10 cells showed increased cell death. Photoluminescence (PL) analyses found that Fo:Yb displayed enhanced blue emission under 980 nm excitation, whereas Fo:Er/Yb exhibited green and red emissions. Data suggest that combining alkalinization effect of forsterite with the up-conversion (UC) photoactivity of NPs might serve as a dual-attack system for <i>in situ</i> oncological treatment.
DOI: 10.6084/m9.figshare.29204697.v1
title: Dual synergetic approach for targeting dysfunctional cells based on rare-earth-doped forsterite nanoparticles

description: In recent years, forsterite (Fo, Mg₂SiO₄) has emerged as a promising biomaterial for bone tissue engineering scaffolds, demonstrating efficacy in inhibiting the growth of clinical bacterial isolates. In addition, rare-earth (RE) doped Fo exhibits excitation properties that match the near-infrared (NIR) biological transparency window (700–1800 nm), facilitating deep penetration into biological tissues. Despite these advantageous properties, data on the toxicity of RE-doped forsterite is lacking, and effects on damaged or dysfunctional cells, such as cancer cells, are not known. The aim of this study was to examine the toxicity of RE-doped forsterite nanoparticles (NPs) in cultures of healthy and tumor skin cells. Specifically, forsterite doped with Er<sup>3+</sup>, Yb<sup>3+</sup>, and a combination of Er<sup>3+</sup>/Yb<sup>3+</sup>, produced via reverse strike coprecipitation (RSC), was employed in cytotoxicity assays. The influence of solution pH on the toxicity response was also investigated. Data demonstrated that all NPs exhibited biocompatibility with HaCaT keratinocytes, while melanoma B16-F10 cells showed increased cell death. Photoluminescence (PL) analyses found that Fo:Yb displayed enhanced blue emission under 980 nm excitation, whereas Fo:Er/Yb exhibited green and red emissions. Data suggest that combining alkalinization effect of forsterite with the up-conversion (UC) photoactivity of NPs might serve as a dual-attack system for <i>in situ</i> oncological treatment.
DOI: 10.6084/m9.figshare.29126986
title: Integrative assessment of the genotoxic effects of the neurotoxin saxitoxin produced by the freshwater cyanobacterium <i>Raphidiopsis raciborskii</i>

description: Saxitoxin (STX), a potent neurotoxin produced by cyanobacteria, has not been comprehensively investigated with respect to genotoxic potential, especially in freshwater environments. This study aimed to characterize the genotoxic potential of STX obtained from <i>Raphidiopsis</i>. <i>raciborskii</i> cultures using <i>in vitro</i> and <i>in silico</i> approaches. Mutagenic potential was determined through the Ames test with <i>Salmonella typhimurium</i> strains TA98, TA100, and TA102. DNA damage and chromosomal instability were assessed in human glioblastoma U87-MG cells using the comet and cytokinesis-block micronucleus cytome (CBMN-Cyt) assay, respectively. In addition, systems biology tools were applied to explore STX interactions with genes involved in DNA damage response pathways. Data demonstrated no marked mutagenic activity in the Ames test across tested concentrations (0.625–10 µg/L). However, significant DNA damage and increased micronucleus (MN) formation were observed at 2.5, 5, or 10 µg/L in U87-MG cells, without accompanying cytotoxicity. <i>In silico</i> analysis identified interactions between STX and key proteins, including P53, CDK5, and GSK3B, indicating pathways related to DNA damage, cell cycle regulation, and neurogenesis. These findings suggest that STX from freshwater cyanobacteria might induce genotoxic effects at environmentally relevant concentrations. The integration of <i>in vitro</i> and computational data supports the need for regulatory monitoring of STX in drinking water and emphasizes the relevance of neural cell-based models in assessing cyanotoxin-related adverse risks.
DOI: 10.6084/m9.figshare.29126986.v1
title: Integrative assessment of the genotoxic effects of the neurotoxin saxitoxin produced by the freshwater cyanobacterium <i>Raphidiopsis raciborskii</i>

description: Saxitoxin (STX), a potent neurotoxin produced by cyanobacteria, has not been comprehensively investigated with respect to genotoxic potential, especially in freshwater environments. This study aimed to characterize the genotoxic potential of STX obtained from <i>Raphidiopsis</i>. <i>raciborskii</i> cultures using <i>in vitro</i> and <i>in silico</i> approaches. Mutagenic potential was determined through the Ames test with <i>Salmonella typhimurium</i> strains TA98, TA100, and TA102. DNA damage and chromosomal instability were assessed in human glioblastoma U87-MG cells using the comet and cytokinesis-block micronucleus cytome (CBMN-Cyt) assay, respectively. In addition, systems biology tools were applied to explore STX interactions with genes involved in DNA damage response pathways. Data demonstrated no marked mutagenic activity in the Ames test across tested concentrations (0.625–10 µg/L). However, significant DNA damage and increased micronucleus (MN) formation were observed at 2.5, 5, or 10 µg/L in U87-MG cells, without accompanying cytotoxicity. <i>In silico</i> analysis identified interactions between STX and key proteins, including P53, CDK5, and GSK3B, indicating pathways related to DNA damage, cell cycle regulation, and neurogenesis. These findings suggest that STX from freshwater cyanobacteria might induce genotoxic effects at environmentally relevant concentrations. The integration of <i>in vitro</i> and computational data supports the need for regulatory monitoring of STX in drinking water and emphasizes the relevance of neural cell-based models in assessing cyanotoxin-related adverse risks.
DOI: 10.6084/m9.figshare.29039102
title: Long-term Quaternary weathering as a geomorphic agent in Alderney (Channel Islands, W Europe)

description: Alderney in the Channel Islands (W Europe) was never glaciated during the Quaternary but rather has been affected by long-term weathering of the underlying igneous and metamorphic rocks. This study investigates the evidence for weathering and sediment generation under mainly cold Quaternary climatic conditions, based on (1) surface geomorphology, (2) Schmidt hammer rebound values on bedrock outcrops, and (3) sediment stratigraphy along coastal sections where weathering-derived solifluction slope sediments are exposed by erosion. Results show the dominance of cold-climate features across the landscape, reflecting the role of late Quaternary periglacial weathering in producing and then mobilizing slope sediments. Both slope stratigraphy and evidence from Schmidt hammer data suggest several phases of weathering activity, but their precise timing is not yet known. Although changes in Quaternary climate (temperature, humidity) and sea level are the most likely drivers for both weathering and slope sediment supply, it is likely that this was not a simple relationship, for example, where there is progressive infilling of slope accommodation space over time. Investigating the relationships between weathering (sediment generation) and slope (sediment deposition) processes, constrained by radiometric dating, offers the best framework for understanding the development of non-glaciated landscapes in western Europe.
DOI: 10.6084/m9.figshare.29039102.v1
title: Long-term Quaternary weathering as a geomorphic agent in Alderney (Channel Islands, W Europe)

description: Alderney in the Channel Islands (W Europe) was never glaciated during the Quaternary but rather has been affected by long-term weathering of the underlying igneous and metamorphic rocks. This study investigates the evidence for weathering and sediment generation under mainly cold Quaternary climatic conditions, based on (1) surface geomorphology, (2) Schmidt hammer rebound values on bedrock outcrops, and (3) sediment stratigraphy along coastal sections where weathering-derived solifluction slope sediments are exposed by erosion. Results show the dominance of cold-climate features across the landscape, reflecting the role of late Quaternary periglacial weathering in producing and then mobilizing slope sediments. Both slope stratigraphy and evidence from Schmidt hammer data suggest several phases of weathering activity, but their precise timing is not yet known. Although changes in Quaternary climate (temperature, humidity) and sea level are the most likely drivers for both weathering and slope sediment supply, it is likely that this was not a simple relationship, for example, where there is progressive infilling of slope accommodation space over time. Investigating the relationships between weathering (sediment generation) and slope (sediment deposition) processes, constrained by radiometric dating, offers the best framework for understanding the development of non-glaciated landscapes in western Europe.
DOI: 10.6084/m9.figshare.28776328
title: The influence of initial lead implantation into niobium substrate on the adhesion of Pb layers obtained in cathodic arc and by magnetron sputtering

description: The procedure for preparing superconducting electron gun Nb-Pb photocathodes, composed of a lead layer deposited on the niobium surface should ensure their sufficient adhesion due to mandatory cleaning of the gun in ultrapure water under high pressure. It is a real challenge since Nb and Pb neither form solid solutions nor present good mutual wettability. So far adequate adhesion has not been achieved. We present a new approach to increase adhesion by preliminary lead implantation into niobium before depositing the final photoemissive Pb layers by magnetron sputtering and in a cathodic arc. The purpose of this study is to demonstrate the effectiveness of such a procedure. The scope of the article includes a description of experiments carried out on 10 trial Nb-Pb photocathodes, showing the impact of using pre-implanted niobium substrates on the adhesion strength of lead layers measured in scratch tests. The results of these tests are interpreted based on the nanoindentation of the transition zones between the layers and substrates. Increased adhesion was reached at a graded change in nanomechanical properties between film and substrate. The way to achieve such gradual transition is proposed for the future work. The presented results serve as a guideline in preparing superconducting Nb-Pb photocathodes.
DOI: 10.6084/m9.figshare.28776328.v1
title: The influence of initial lead implantation into niobium substrate on the adhesion of Pb layers obtained in cathodic arc and by magnetron sputtering

description: The procedure for preparing superconducting electron gun Nb-Pb photocathodes, composed of a lead layer deposited on the niobium surface should ensure their sufficient adhesion due to mandatory cleaning of the gun in ultrapure water under high pressure. It is a real challenge since Nb and Pb neither form solid solutions nor present good mutual wettability. So far adequate adhesion has not been achieved. We present a new approach to increase adhesion by preliminary lead implantation into niobium before depositing the final photoemissive Pb layers by magnetron sputtering and in a cathodic arc. The purpose of this study is to demonstrate the effectiveness of such a procedure. The scope of the article includes a description of experiments carried out on 10 trial Nb-Pb photocathodes, showing the impact of using pre-implanted niobium substrates on the adhesion strength of lead layers measured in scratch tests. The results of these tests are interpreted based on the nanoindentation of the transition zones between the layers and substrates. Increased adhesion was reached at a graded change in nanomechanical properties between film and substrate. The way to achieve such gradual transition is proposed for the future work. The presented results serve as a guideline in preparing superconducting Nb-Pb photocathodes.
DOI: 10.15468/dl.mjwvg2
title: Occurrence Download

description: A dataset containing 282 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Stachys menthifolia"
 ]
}

 The dataset includes 282 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015535-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s9tapd
title: Occurrence Download

description: A dataset containing 95 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Saussurea apus"
 ]
}

 The dataset includes 95 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0015536-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2jy19v
title: CCDC 2351607: Experimental Crystal Structure Determination

description: Related Article: Bhawna Joshi, Devesh Kumar Mishra, Amit Pratap Singh|2025|Inorg.Chem.Commun.|180|115037|doi:10.1016/j.inoche.2025.115037
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2k9mbv
title: CCDC 2362737: Experimental Crystal Structure Determination

description: Related Article: Hongyan Bi, Chaoren Shen, Sunewang R. Wang|2025|Angew.Chem.,Int.Ed.|64|e202415839|doi:10.1002/anie.202415839
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2k9mcw
title: CCDC 2362738: Experimental Crystal Structure Determination

description: Related Article: Hongyan Bi, Chaoren Shen, Sunewang R. Wang|2025|Angew.Chem.,Int.Ed.|64|e202415839|doi:10.1002/anie.202415839
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.