cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5286/isis.e.rb2520418-1
title: mRNA-lipid nanoparticle surfaces, endocytosis, and endosomal escape: a structure-activity relationship

description: mRNA vaccines against infectious disease and cancer require encapsulation in lipid nanoparticles (LNPs) to improve stability and cell entry. Polyethylene glycol (PEG) lipids are used to stabilise the LNP surface. However PEG impairs endocytic cellular uptake and escape from endosomes, likely by reducing bilayer interactions. These are 2 key cellular barriers to mRNA-LNP efficacy. Moreover, increasing allergic response to PEG in patients who receive mRNA-LNP vaccines limits the safety and efficacy of mRNA-LNPs. I have synthesised alternative polymer-lipids that improve mRNA-LNP efficacy by 100-fold in vitro and 3-fold in vivo compared to formulations containing PEG. However, the mechanism behind this improved efficacy is unclear.
This project aims to uncover the mechanism by which LNP surface chemistry impacts cellular endocytosis and endosomal escape by using neutron reflectometry (NR) to resolve molecular interactions between model lipid bilayers and 4 LNPs with unique surfaces (no polymer, PEG, a commercial PEG alternative, and my leading novel PEG alternative) at physiological and endosomal pH (7.4, 5.5 respectively). NR will provide unreported biophysical insights unachievable via other techniques. These data will be complemented by in vitro microscopy and in silico molecular dynamic simulations to build a structure-activity relationship between LNP surface chemistry, endocytosis, and endosomal escape that will inform the design of future mRNA-LNPs with enhanced potency.
DOI: 10.5286/isis.e.rb2520418
title: mRNA-lipid nanoparticle surfaces, endocytosis, and endosomal escape: a structure-activity relationship

description: mRNA vaccines against infectious disease and cancer require encapsulation in lipid nanoparticles (LNPs) to improve stability and cell entry. Polyethylene glycol (PEG) lipids are used to stabilise the LNP surface. However PEG impairs endocytic cellular uptake and escape from endosomes, likely by reducing bilayer interactions. These are 2 key cellular barriers to mRNA-LNP efficacy. Moreover, increasing allergic response to PEG in patients who receive mRNA-LNP vaccines limits the safety and efficacy of mRNA-LNPs. I have synthesised alternative polymer-lipids that improve mRNA-LNP efficacy by 100-fold in vitro and 3-fold in vivo compared to formulations containing PEG. However, the mechanism behind this improved efficacy is unclear.
This project aims to uncover the mechanism by which LNP surface chemistry impacts cellular endocytosis and endosomal escape by using neutron reflectometry (NR) to resolve molecular interactions between model lipid bilayers and 4 LNPs with unique surfaces (no polymer, PEG, a commercial PEG alternative, and my leading novel PEG alternative) at physiological and endosomal pH (7.4, 5.5 respectively). NR will provide unreported biophysical insights unachievable via other techniques. These data will be complemented by in vitro microscopy and in silico molecular dynamic simulations to build a structure-activity relationship between LNP surface chemistry, endocytosis, and endosomal escape that will inform the design of future mRNA-LNPs with enhanced potency.
DOI: 10.26023/1bzj-z6hz-630w
title: START08: UCATS 2-Channel Gas Chromatograph. Version 1.0

description: This dataset contains txt files of data from the Unmanned Aircraft Systems (UAS) Chromatograph for Atmospheric Trace Species (UCATS) 2-channel gas chromatograph (GC). Data were collected during START08 flights of the NCAR GV.
DOI: 10.25921/rnt3-6g61
title: Effects of food supply on northern bay scallops (Argopecten irradians) reared under two pCO2 conditions from 2021-09-14 to 2021-10-26 (NCEI Accession 0289954)

description: The effects of food supply on bivalves under long-term ocean acidification exposure remains incompletely understood. In this study, juvenile northern bay scallops (50 days post fertilization), Argopecten irradians, that had been reared since 4 hours post-fertilization under one of two ocean acidification conditions (~500-600 or ~750-850 µatm pCO2; ~1.37-1.5 or ~1.0-1.2 Ωaragonite), were subjected to two food levels for 42-days (low food = ~400 and high food = ~1,400 chlorophyll cells mL-1). Standard metabolic rate (SMR) and clearance rate (CR) were measured at day 0 and standard metabolic rate, clearance rate, growth, and survivorship were measured at 14 and 42 days of exposure to two food levels for each of the ocean acidification treatments. This data archive contains (i) seawater carbonate chemistry and discrete seawater chemistry records throughout the experiment (ii) standard metabolic rates, (iii) clearance rates, (iv) survival, (v) shell length, (vi) shell and tissue dry weights ,(vii) and experiment metadata.
DOI: 10.25921/fawy-5g12
title: Surface underway measurements of partial pressure of carbon dioxide (pCO2), water temperature, salinity, barometric pressure and other variables during the CCGS Hudson Atlantic Zone Offshore Monitoring Program (AZOMP) cruises in Labrador Sea, Scotian Shelf, Newfoundland Shelf and North Atlantic Ocean in 2016 (NCEI Accession 0290072)

description: This dataset includes surface underway measurements of partial pressure of carbon dioxide (pCO2), water temperature, salinity, barometric pressure and other variables during the CCGS Hudson Atlantic Zone Offshore Monitoring Program (AZOMP) cruises in Labrador Sea, Scotian Shelf, Newfoundland Shelf and North Atlantic Ocean from 2016-04-28 to 2016-05-23.
DOI: 10.25921/yery-jf24
title: Surface underway measurements of partial pressure of carbon dioxide (pCO2), water temperature, salinity, barometric pressure and other variables during the CCGS Hudson Atlantic Zone Monitoring Program (AZMP) cruises in Gulf of Maine, Labrador Sea, Scotian Shelf, Newfoundland Shelf and North Atlantic Ocean in 2018 (NCEI Accession 0290118)

description: This dataset includes surface underway measurements of partial pressure of carbon dioxide (pCO2), water temperature, salinity, barometric pressure and other variables during the CCGS Hudson Atlantic Zone Monitoring Program (AZMP) cruises in Gulf of Maine, Labrador Sea, Scotian Shelf, Newfoundland Shelf and North Atlantic Ocean from 2018-04-04 to 2018-10-05. This dataset is U.S. State Department MSR U2018-009 as part of the World Data Service for Oceanography.
DOI: 10.25921/2kxq-8t60
title: Surface underway measurements of partial pressure of carbon dioxide (pCO2), water temperature, salinity, barometric pressure and other variables during R/V Endeavor Atlantic Zone Monitoring Program (AZMP) cruises in Gulf of Maine, Scotian Shelf, Newfoundland Shelf and North Atlantic Ocean in 2017 (NCEI Accession 0290125)

description: This dataset includes surface underway measurements of partial pressure of carbon dioxide (pCO2), water temperature, salinity, barometric pressure and other variables during R/V Endeavor Atlantic Zone Monitoring Program (AZMP) cruises in Gulf of Maine, Scotian Shelf, Newfoundland Shelf and North Atlantic Ocean from 2017-11-24 to 2017-12-16.
DOI: 10.5281/zenodo.17257504
title: Dati meteorologici presso la stazione meteorologica di Oppido Mamertina ARSAC dal 2000 al 2025
DOI: 10.5281/zenodo.17257505
title: Dati meteorologici presso la stazione meteorologica di Oppido Mamertina ARSAC dal 2000 al 2025
DOI: 10.15468/dl.s4xj5h
title: Occurrence Download

description: A dataset containing 197889 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Colombia",
 "TaxonKey is one of (Pitcairnia, Tillandsia)"
 ]
}

 The dataset includes 197889 records from 334 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043209-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7dupru
title: Occurrence Download

description: A dataset containing 24300 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Geometry POLYGON((7.90495 49.11253,9.11128 43.62923,14.64942 43.51956,21.11971 38.42009,32.08632 43.30023,30.44133 51.08652,17.88457 51.90901,7.90495 49.11253))",
 "OccurrenceStatus is Present",
 "TaxonKey is Ardeola ralloides"
 ]
}

 The dataset includes 24300 records from 32 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043222-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25921/9hhb-d547
title: Surface observations of partial pressure (or fugacity) of carbon dioxide and water temperature collected from Fixed Ocean Time Series Mooring Östergarnsholm in the Baltic Sea from 2022-10-31 to 2024-11-11 (NCEI Accession 0292119)

description: This dataset includes Surface observations of partial pressure (or fugacity) of carbon dioxide and water temperature collected from Fixed Ocean Time Series Mooring Östergarnsholm in the Baltic Sea from 2022-10-31 to 2024-11-11. Fixed buoy in the Baltic Sea at 5m depth is part of ICOS (Integrated Carbon Observation System).
DOI: 10.25921/wwqk-fq06
title: Fugacity of carbon dioxide (fCO2), temperature, salinity and other variables collected from surface underway observations using shower head equilibrator, carbon dioxide gas detector and other instruments from R/V Thomas G. Thompson cruises in the Pacific Ocean in 2023 (NCEI Accession 0292121)

description: This dataset consists of surface underway ocean measurements of fugacity of carbon dioxide (fCO2), salinity, and sea surface temperature collected during R/V Thomas G. Thompson cruises in the Pacific Ocean from 2023-01-22 to 2024-01-10. The measurements were collected to evaluate the spatial distribution of air-sea CO2 flux. These measurements were collected with support from NOAA's Global Ocean Monitoring and Observing (GOMO) Program.
DOI: 10.25921/xk2x-hw26
title: Fugacity of carbon dioxide (fCO2), temperature, salinity and other variables collected from surface underway observations during the NOAA Ship Bell M. Shimada cruises on the continental shelf of the US West Coast in 2023 (NCEI Accession 0292123)

description: This dataset contains surface underway measurements of fugacity of carbon dioxide (fCO2), sea surface salinity, sea surface temperature, and other parameters collected during NOAA Ship Bell M. Shimada cruises on the continental shelf of the US West Coast in 2023. This effort was conducted in support of the coastal monitoring and research objectives of the NOAA Ocean Acidification Program (OAP).
DOI: 10.15468/dl.7qybt8
title: Occurrence Download

description: A dataset containing 1122132 records in GBIF matching the query:
SELECT
 occurrenceid,
 organismid,
 scientificname,
 classkey,
 eventdate,
 decimallatitude,
 decimallongitude,
 datasetkey,
 publisher
FROM
 occurrence
WHERE
 GBIF_STRINGARRAYCONTAINS(occurrence.networkkey, 'ab013f3a-3c00-42cb-9fdb-cb5f4ba20a4b', FALSE)
 AND occurrence."year" = 2020
 AND occurrence.occurrencestatus = 'PRESENT'
 AND occurrence.basisofrecord = 'MACHINE_OBSERVATION'

 The dataset's 1122132 records were derived from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043213-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2nwqdp
title: CCDC 2469503: Experimental Crystal Structure Determination

description: Related Article: Hao Li, Yanan Xu, Shiyue Zhang, Pengliang Gu, Qing Hu, Yu Zhang, Wenkai Wang, Zhan Shi, Xinyi Fu, Hongbin Du|2025|Dalton Trans.|54|13775|doi:10.1039/d5dt01561h
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2nx16v
title: CCDC 2469807: Experimental Crystal Structure Determination

description: Related Article: Hao Li, Yanan Xu, Shiyue Zhang, Pengliang Gu, Qing Hu, Yu Zhang, Wenkai Wang, Zhan Shi, Xinyi Fu, Hongbin Du|2025|Dalton Trans.|54|13775|doi:10.1039/d5dt01561h
description: Related Article: Li Hao|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.25921/j991-4469
title: Parrotfish surveys and paired coral and parrotfish coral predation surveys conducted in the Caribbean Sea and Florida Keys National Marine Sanctuary from 2013-07-02 to 2019-09-11 (NCEI Accession 0293333)

description: Data associated with the publication 'Ecological drivers of parrotfish coral predation vary across spatial scales', comparing parrotfish coral predation intensity as it relates to parrotfish density/biomass, coral cover, and other ecological variables from the scale of individual coral colonies to reefs spanning four regions of the Greater Caribbean. This dataset includes several datasets:

1) regional_coral_scar_data.csv: Surveys of coral colonies (with and without parrotfish predation scars) across all regions.

2) processed_coral_scar_data_colony_level.csv: Processed data from the file above filtered to only include coral taxa commonly predated by parrotfishes (determined as coral taxa for which at least 3 colonies across the entire dataset had 3 recent parrotfish predation scars). This includes the calculated coral colony surface area and the estimated total/sum recent scar area per coral colony.

3) regional_fish_data.csv: Parrotfish abundance and size for individuals greater than or equal to 15 cm fork length. This data includes estimated fish weight and related length-weight conversion values used to calculate these values.

4) site_coordinates.csv: Metadata of the latitude and longitude of all study sites.
DOI: 10.26023/88w7-d5b2-zs0x
title: START08: UCATS Dual-beam Ozone Photometer. Version 1.0

description: This dataset contains txt file data from the Unmanned Aircraft Systems (UCAS) Chromatograph for Atmospheric Trace Species (UCATS) Dual-beam ozone photometer (OZ). Data were collected for the START08 experiment on the NCAR GV aircraft.
DOI: 10.5281/zenodo.17257509
title: Intensivkapazitäten und COVID-19-Intensivbettenbelegung in Deutschland

description: Der Datensatz "Intensivkapazitäten und COVID-19-Intensivbettenbelegung in Deutschland" des Robert Koch-Instituts dokumentiert die tägliche intensivmedizinische Versorgungslage seit der COVID-19-Pandemie. Basierend auf Meldungen aller intensivbettenführenden Krankenhäuser in Deutschland erfasst das DIVI-Intensivregister Echtzeitdaten zu belegten und freien Intensivbetten. Die Erhebung differenziert nach Altersgruppen, Regionen und Versorgungsstufen. COVID-19-Fälle auf Intensivstationen werden gesondert ausgewiesen. Die Daten stehen aggregiert auf Bundes-, Landes- und Kreisebene zur Verfügung. Damit bildet der Datensatz eine Grundlage für die Überwachung von Kapazitäten, die Koordination von Behandlungskapazitäten und politische Entscheidungsprozesse während der Pandemie und darüber hinaus.
DOI: 10.15468/dl.p4rukb
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Leucanthemum ircutianum",
 "Country is Denmark",
 "HasCoordinate is true"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043224-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25921/z66e-rq30
title: Timeseries of temperature, salinity, ADCP velocity with ice track, nitrate, fluorescence, turbidity, dissolved oxygen collected from Bering Strait Moorings A2, A3, A4 in Bering Strait from 2022-09-11 to 2023-07-13 (NCEI Accession 0297059)

description: Bering Strait Moorings 2022-2023

This is an archive of data from moorings deployed in Bering Strait from summer 2022 and to summer 2023.

Mooring deployments were funded by the NSF-Arctic Observing Network award PLR-2153942 (PIs: Woodgate and Peralta-Ferriz).

The mooring work required 2 dedicated cruises:
- in 2022 (8th-19th September), a ~ 12 day cruise on the US vessel Norseman2 deployed the moorings. Some CTD sections were run on this cruise, and those data are archived separately.
- in 2023 (4th-14th July), a ~ 11 day cruise on the US vessel Norseman2 recovered the moorings. Some CTD sections were run on this cruise, and those data are archived separately.

In 2022, a total of three moorings were deployed:
- two moorings (A2 and A4) in the US channel of the strait,
- one mooring (A3) at a site just north of the strait.
In what follows, mooring names include a two digit suffix to represent year of deployment. In 2023, all three moorings were successfully recovered.

Sites A2, and A3 were established in 1990. A2 and A3 have been occupied almost continuously (all years except 96-97) since then. Site A4 was established in 2001. Mooring location A2 is in the middle of the eastern (Alaskan side) channel. Mooring location A3 is just north of the strait, immediately east of the Russian-US EEZ (Exclusive Economic Zone) line. Experience has shown that site A3 samples both eastern and western channel water. Mooring location A4 is close to the Alaskan coast and allows measurement of the Alaskan Coastal Current.
DOI: 10.25921/v2w7-6s48
title: Oceanographic profile temperature and salinity data collected by instrumented marine mammals in the Southern Ocean, South Atlantic and other locations for the Marine Mammals Exploring the Oceans Pole to Pole (MEOP) project from 2004-01-27 to 2024-02-22 (NCEI Accession 0297525)

description: Temperature and salinity CTD data from the Marine Mammals Exploring the Ocean Pole to Pole (MEOP) program. This dataset largely samples high northern and southern latitudes using instrumented (CTD) animals (elephant seals). There are several hundred thousand profiles in this data set which runs from 2004 to 2024. Data are in NetCDF. Downloaded from the MEOP database on 2024/08/12.
DOI: 10.15468/dl.8n9n3x
title: Occurrence Download

description: A dataset containing 3712488 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Plantae",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 2016",
 "Year is less than or equal to 2021",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Country is United Kingdom of Great Britain and Northern Ireland",
 {
 "or" : [
 {
 "not" : {
 "EstablishmentMeans" : [
 "is one of (MANAGED, INTRODUCED)"
 ]
 }
 },
 "EstablishmentMeans is null"
 ]
 },
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 1000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 3712488 records from 185 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043193-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g56hed
title: Occurrence Download

description: A dataset containing 38827 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Machine Observation, Observation)",
 "Country is Estonia",
 "GadmGid is EST.1.20_1",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Month is one of (January, May, June, July, April, August, September)",
 "OccurrenceStatus is Present",
 "TaxonKey is Aves",
 "Year 2020-2024"
 ]
}

 The dataset includes 38827 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043225-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.26023/tqrz-vee8-cj0c
title: START08: UCATS Tunable Diode Laser (TDL) Spectrometer for Water Vapor. Version 1.0

description: This dataset contains txt file data from the Unmanned Aircraft Systems (UCAS) Chromatograph for Atmospheric Trace Species (UCATS) Tunable Diode Laser (TDL) Spectrometer for water Vapor. Data were collected for the START08 experiment on the NCAR GV aircraft.
DOI: 10.15468/dl.zgu9y2
title: Occurrence Download

description: A dataset containing 474 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lindsaea agatii"
 ]
}

 The dataset includes 474 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043226-250920141307145/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25921/b0hj-ww50
title: Water temperature, salinity, pressure taken by CTD attached to marine mammals for the Marine Mammals Exploring the Oceans Pole to Pole (MEOP) project in the Indian, S. Atlantic, and S. Pacific Oceans from 2014-10-20 to 2019-01-23 (NCEI Accession 0300708)

description: This dataset is a copy of MEOP-SMS Database (submesoscale sampling of the ocean). It contains Water temperature, salinity, pressure taken by CTD attached to marine mammals for the Marine Mammals Exploring the Oceans Pole to Pole (MEOP) project in the Indian, S. Atlantic, and S. Pacific Oceans.

The MEOP-SMS database is a collection of CTD data gathered with CTD-SRDLs attached to elephant seals. The CTD-SRDLs were set in continuous recording mode, and could be retrieved, enabling retrieval of the entire CTD archive at the sampling frequency (0.5 Hz) for periods of several months. Instruments were deployed at the Kerguelen Islands and at Peninsula Valdes (Argentina) as part of the SO-MEMO program led by Christophe Guinet (CEBC/CNRS, France).

Data are provided in the form of profiles (format ncARGO). A description of the dataset and the post-processing can be found in Siegelman et al., 2019 (see the Documentation).
DOI: 10.25921/hp26-vh80
title: Cetacean visual observations and environmental parameters collected by CTD and other instruments onboard the NOAA Ship Gordon Gunter (GU) in the Gulf of America, for the Trophic Interactions and Habitat Requirements of Gulf of America Rice’s Whales project (RESTORE survey GU1806) from 2018-11-11 to 2018-12-03 (NCEI Accession 0301293)

description: As part of a Resources and Ecosystems Sustainability, Tourist Opportunities, and Revived Economies (RESTORE) Science Program project, the Southeast Fisheries Science Center (SEFSC), in collaboration with Scripps Institution of Oceanography (SIO) and Florida International University (FIU), conducted a shipboard survey in the northeastern Gulf of America from 2018-11-11 to 2018-12-03. Operations occurred in waters where Rice’s whales (Balaenoptera ricei) were previously sighted, between the 180 m and 400 m isobaths from the Florida panhandle to Tampa. The survey was designed with a focus on baleen whales, although sightings of other species were opportunistically recorded. A sighting constituted a single or group of marine mammals (whales and dolphins) seen at the same location and time. This dataset includes marine mammal visual observation data and effort points with surveying conditions, opportunistic marine mammal photographs, and non-marine mammal sightings (a.k.a. occurrences) such as sea turtles. Raw files from conductivity, temperature and depth (CTD) casts performed on a daily basis during the survey are also available.
DOI: 10.5281/zenodo.17257511
title: Set of Contracts, Scripts, and benchmarking for Jophiel Arevalo's Thesis
DOI: 10.5281/zenodo.17257512
title: Set of Contracts, Scripts, and benchmarking for Jophiel Arevalo's Thesis