cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30390991.v1
title: Supplementary Material for: Association of Monocyte-Lymphocyte Ratio with Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: A Prospective Cohort Study

description: Introduction
Elevated monocyte to lymphocyte ratio (MLR) represents a pro-inflammatory immune microenvironment and has been associated with poor clinical outcomes such as cardiovascular disease. However, little is known about its association with outcomes among patients on hemodialysis.
Methods
In a nationwide prospective cohort of 952 patients receiving maintenance hemodialysis from 2011-2013, we examined the association of baseline MLR with subsequent risk of cardiovascular events (cardiovascular-related hospitalization and cardiovascular death) and all-cause mortality, using multivariable Cox proportional hazards models with adjustment for potential confounders. We also examined the mediation effect of inflammatory markers on the association between MLR and cardiovascular events and all-cause mortality, respectively.
Results
Overall, patients were 60.1±13.4 years old; 53.3% were male; 39.7% were African American; and 56.9% were diabetic. The median dialysis vintage was 3.1 years. During a median follow-up of 2.1 years, 184 and 207 cases experienced cardiovascular events and all-cause death, respectively. A higher MLR was incrementally associated with higher risk of cardiovascular events and all-cause mortality. The multivariable-adjusted hazard ratios (95% confidence interval) of cardiovascular events and all-cause mortality for 0.1 unit increase in MLR were 1.22 (1.09-1.37) and 1.18 (1.07-1.30), respectively. There was a modest but significant mediation effect of plasma interleukin-6 (IL-6) on the association between MLR and cardiovascular events (28.2%) and all-cause mortality (24.1%).
Conclusion
A higher MLR was independently associated with higher risk of cardiovascular events and all-cause mortality in patients on hemodialysis. Our findings suggest the potential of MLR as a simple, cost-effective prognostic biomarker and support IL-6-targeted therapeutic interventions to improve clinical outcomes in patients with ESKD.
DOI: 10.3535/76f-hrw-msd
title: Callianassa chakratongae Sakai 2002

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/qty-r95-7dp
title: Upogebia yokoyai Makarov 1938

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/g4e-2zf-jvh
title: Callianassa plantei Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/j8d-pvy-r47
title: Gourretia nosybeensis Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/prl-a0a-dqe
title: Upogebia yokoyai Makarov 1938

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/hm6-9v4-hev
title: Callianassa plantei Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/j5y-sdd-gmq
title: Callianassa plantei n. sp.

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/wx8-fgk-lcn
title: Callianassa plantei n. sp.

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.6084/m9.figshare.30390994
title: Supplementary Material for: Exploring Neuroinflammation and Its Role in Postoperative Cognitive Dysfunction Following Spine Surgery

description: Abstract: Background: Progress in spine surgery has significantly improved the safety of proce-dures for older patients with disabling spine disease. However, postoperative cognitive dysfunction (POCD) remain a concern due to their link with poorer outcomes and higher long-term care risk. This study aimed to determine if pro-neuroinflammatory states accelerate neurodegeneration, contributing to POCD development, and explore whether specific biomarkers could predict POCD risk. Methods: Patients (aged ≥ 60 years) scheduled for elective spine surgery between February 2018 and March 2020 were enrolled. Biomarkers tested included IL-6, CRP, S100 calcium-binding protein β (S100β), Brain-derived neurotrophic factor (BDNF), Neurofilament light chain protein (sNFL), Gasdermin D, and soluble ectodomain of triggering receptor expressed on myeloid cells 2 (sTREM2), measured pre-operatively and postoperatively. Cognitive outcomes were assessed using the CERAD test battery at baseline and three months postoperatively. Results: Postoperative levels of sTREM2 and Gasdermin D were significantly associated with cognitive performance changes three months after surgery, particularly in memory function. Higher sTREM2 levels were associated with greater cognitive decline, with six out of twelve CERAD items showing an inverse association (e.g., overall β = -0.010, p = 0.0003). Similarly, higher postoperative Gasdermin D levels were linked to worse performance, particularly in recognition memory (e.g., word list recognition β = -0.615, p = 0.032). Additionally, higher preoperative sNFL levels were associated with poorer cog-nitive outcomes across multiple domains. Conclusions: This study highlights potential associations between neuroinflammation and cognitive decline following spine surgery. Targeting neuroin-flammatory pathways could be crucial in mitigating POCD in older patients. Biomarkers may help identify high-risk patients and guide the development of targeted interventions.
DOI: 10.3535/ab5-pt9-t3n
title: Callianassa plantei Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/wtt-rza-1g7
title: Callianassa sp.

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/xd4-d1e-kg6
title: Callianassa plantei Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.6084/m9.figshare.30390994.v1
title: Supplementary Material for: Exploring Neuroinflammation and Its Role in Postoperative Cognitive Dysfunction Following Spine Surgery

description: Abstract: Background: Progress in spine surgery has significantly improved the safety of proce-dures for older patients with disabling spine disease. However, postoperative cognitive dysfunction (POCD) remain a concern due to their link with poorer outcomes and higher long-term care risk. This study aimed to determine if pro-neuroinflammatory states accelerate neurodegeneration, contributing to POCD development, and explore whether specific biomarkers could predict POCD risk. Methods: Patients (aged ≥ 60 years) scheduled for elective spine surgery between February 2018 and March 2020 were enrolled. Biomarkers tested included IL-6, CRP, S100 calcium-binding protein β (S100β), Brain-derived neurotrophic factor (BDNF), Neurofilament light chain protein (sNFL), Gasdermin D, and soluble ectodomain of triggering receptor expressed on myeloid cells 2 (sTREM2), measured pre-operatively and postoperatively. Cognitive outcomes were assessed using the CERAD test battery at baseline and three months postoperatively. Results: Postoperative levels of sTREM2 and Gasdermin D were significantly associated with cognitive performance changes three months after surgery, particularly in memory function. Higher sTREM2 levels were associated with greater cognitive decline, with six out of twelve CERAD items showing an inverse association (e.g., overall β = -0.010, p = 0.0003). Similarly, higher postoperative Gasdermin D levels were linked to worse performance, particularly in recognition memory (e.g., word list recognition β = -0.615, p = 0.032). Additionally, higher preoperative sNFL levels were associated with poorer cog-nitive outcomes across multiple domains. Conclusions: This study highlights potential associations between neuroinflammation and cognitive decline following spine surgery. Targeting neuroin-flammatory pathways could be crucial in mitigating POCD in older patients. Biomarkers may help identify high-risk patients and guide the development of targeted interventions.
DOI: 10.3535/441-s5z-r5g
title: Crangon allmanni Kinahan 1857

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/at1-vl6-tjt
title: Trichoniscus pusillus Brandt 1833

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/nwb-2dd-dcm
title: Philoscia muscorum (Scopoli 1763)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/l93-g8x-ym5
title: Eriocheir sinensis H. Milne-Edwards 1853

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/lsr-252-wyr
title: Dilocarcinus pagei Stimpson 1861

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/ngb-wm8-b1f
title: Eriocheir sinensis H. Milne-Edwards 1853

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/09n-l5j-qlp
title: Valdivia serrata White 1874

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/f7y-vq8-qxb
title: Plesionika edwardsii (Brandt 1851)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.6084/m9.figshare.30390997
title: Supplementary Material for: Collagen I Derived Extracellular Matrix Motifs Alter Fibroblast Regenerative Response

description: Introduction
Damage-associated molecular patterns, or DAMPs, are molecules released in response to tissue or cellular damage to facilitate tissue regeneration. This inflammatory response can occur in sterile environments and is promoted by the release of damaged extracellular components such as the extracellular matrix. DAMPs have been implicated in various stages of wound healing but have yet to be explicitly utilized for regenerative medicine by leveraging selective modulation of the inflammatory response. With this in mind, we leverage inflammation to drive tissue regeneration by utilizing DAMPs collected from the native extracellular matrix, extracellular matrix motifs (mECM). 
Methods
Here, mECMs were derived from UV-damaged rat tail collagen I. Fibroblast response to various concentrations and presentation of mECMs was investigated by evaluating changes in viability, proliferation, cell phenotype, and cytokine secretion. 
Results
mEMCs had reduced intensity in collagen I associated bands, indicating successful fragmentation to lower molecular weights. Soluble free mECMs induced changes in fibroblast phenotype as indicated by a decrease in proliferation, decrease in nuclei area, and increase in percentage of elongated cells. In addition, free mECMs contributed to significant increases in cytokine secretion compared to insoluble bound mECMs. Across all experiments, bound mECMs exhibited effects on fibroblasts compared to the collagen control
Conclusion
Fibroblasts in vitro recognize mECMs, with significant differences observed based on the presentation of these proteins. This data indicates that cryptic regions that are recognized by fibroblasts may be exposed in the free version of the mECMs, which lead to a myofibroblast-like phenotype in fibroblasts. This work highlights the potential of DAMPs to serve as immunomodulatory therapeutics for tissue regeneration.
DOI: 10.6084/m9.figshare.30390997.v1
title: Supplementary Material for: Collagen I Derived Extracellular Matrix Motifs Alter Fibroblast Regenerative Response

description: Introduction
Damage-associated molecular patterns, or DAMPs, are molecules released in response to tissue or cellular damage to facilitate tissue regeneration. This inflammatory response can occur in sterile environments and is promoted by the release of damaged extracellular components such as the extracellular matrix. DAMPs have been implicated in various stages of wound healing but have yet to be explicitly utilized for regenerative medicine by leveraging selective modulation of the inflammatory response. With this in mind, we leverage inflammation to drive tissue regeneration by utilizing DAMPs collected from the native extracellular matrix, extracellular matrix motifs (mECM). 
Methods
Here, mECMs were derived from UV-damaged rat tail collagen I. Fibroblast response to various concentrations and presentation of mECMs was investigated by evaluating changes in viability, proliferation, cell phenotype, and cytokine secretion. 
Results
mEMCs had reduced intensity in collagen I associated bands, indicating successful fragmentation to lower molecular weights. Soluble free mECMs induced changes in fibroblast phenotype as indicated by a decrease in proliferation, decrease in nuclei area, and increase in percentage of elongated cells. In addition, free mECMs contributed to significant increases in cytokine secretion compared to insoluble bound mECMs. Across all experiments, bound mECMs exhibited effects on fibroblasts compared to the collagen control
Conclusion
Fibroblasts in vitro recognize mECMs, with significant differences observed based on the presentation of these proteins. This data indicates that cryptic regions that are recognized by fibroblasts may be exposed in the free version of the mECMs, which lead to a myofibroblast-like phenotype in fibroblasts. This work highlights the potential of DAMPs to serve as immunomodulatory therapeutics for tissue regeneration.
DOI: 10.3535/3rr-wnx-0gm
title: Kingsleya latifrons (Randall 1840)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/nr8-6zc-7nr
title: Eriocheir sinensis H. Milne-Edwards 1853

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/pk3-xbn-016
title: Philoscia muscorum (Scopoli 1763)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/hcw-att-tcg
title: Diogenes pugilator (Roux 1829)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/wgd-rwg-51j
title: Tachaea spongillicola Stebbing 1907

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/xcq-51j-f9m
title: Pisidia longicornis (Linnaeus 1767)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/9f8-6jy-285
title: Haplophthalmus montivagus Verhoeff 1941

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/bfj-qj3-taw
title: Stoliczia gapensis (Bott 1966)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/0h3-fgq-hnf
title: Callianassa plantei Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/34n-y6x-szc
title: Hyloniscus riparius (C. L. Koch 1838)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/ab4-61r-lmw
title: Diogenes pugilator (Roux 1829)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/vnp-rkg-5rm
title: Valdivia serrata White 1874

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.6084/m9.figshare.30391000
title: Supplementary Material for: Management of Recurrent Staphylococcus-related Marginal Keratitis with Chlorhexidine-Vancomycin Combination: A 1-Year Follow-Up Case Report

description: Staphylococcus-related marginal keratitis is an inflammation of the corneal periphery characterized by the presence of stromal infiltrates and blepharoconjunctivitis. Conventional treatment consists of antibiotics and corticosteroid eye drops, and recurrence is prevalent upon treatment cessation. In this case report, we present a one-year follow-up of the results of a novel therapeutic approach for recurrent marginal keratitis using a combination of Chlorhexidine and Vancomycin eye drops.

A 34-year-old male presented with an eight-year history of recurrent staphylococcus-related marginal keratitis in his right eye, consisting of 5 acute episodes, which under a conventional treatment regimen resolved within 10-14 days. During the follow-up of his right eye, an inflammation in his left eye developed as well. Treatment with a combination of Chlorhexidine at 0.02% and Vancomycin at 50 mg/mL eye drops brought rapid resolution of the acute inflammation with preservation of the effect for at least one year.

A combination of Chlorhexidine and Vancomycin eye drops may provide an effective treatment for marginal keratitis. It demonstrated rapid improvement and maintained long-term stability, with disease control observed throughout one year of follow-up.
DOI: 10.6084/m9.figshare.30391000.v1
title: Supplementary Material for: Management of Recurrent Staphylococcus-related Marginal Keratitis with Chlorhexidine-Vancomycin Combination: A 1-Year Follow-Up Case Report

description: Staphylococcus-related marginal keratitis is an inflammation of the corneal periphery characterized by the presence of stromal infiltrates and blepharoconjunctivitis. Conventional treatment consists of antibiotics and corticosteroid eye drops, and recurrence is prevalent upon treatment cessation. In this case report, we present a one-year follow-up of the results of a novel therapeutic approach for recurrent marginal keratitis using a combination of Chlorhexidine and Vancomycin eye drops.

A 34-year-old male presented with an eight-year history of recurrent staphylococcus-related marginal keratitis in his right eye, consisting of 5 acute episodes, which under a conventional treatment regimen resolved within 10-14 days. During the follow-up of his right eye, an inflammation in his left eye developed as well. Treatment with a combination of Chlorhexidine at 0.02% and Vancomycin at 50 mg/mL eye drops brought rapid resolution of the acute inflammation with preservation of the effect for at least one year.

A combination of Chlorhexidine and Vancomycin eye drops may provide an effective treatment for marginal keratitis. It demonstrated rapid improvement and maintained long-term stability, with disease control observed throughout one year of follow-up.
DOI: 10.3535/ery-j89-fsh
title: Elsalvadoria tomhaasi Bott 1970

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/k5a-wf2-3xt
title: Diogenes pugilator (Roux 1829)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/l2m-3df-tb8
title: Hyloniscus riparius (C. L. Koch 1838)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/72a-k80-z03
title: Porcellionides pruinosus (Brandt 1833)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/kvg-wcz-zln
title: Potamiscus phuluangensis (Bott 1970)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/e7b-m8j-fr7
title: Valdivia serrata White 1874

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/tec-sze-xr4
title: Eriocheir sinensis H. Milne-Edwards 1853

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/x71-tm6-9kz
title: Potamon (Eutelphusa) algeriense Bott 1967

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/0rp-pq1-1ed
title: Diogenes pugilator (Roux 1829)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/b7t-va6-3mg
title: Natatolana

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/dq2-q4z-0sh
title: Phronima sedentaria Forskal 1775

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/156-z8e-wh7
title: Diogenes pugilator (Roux 1829)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/spw-7sw-1ew
title: Liocarcinus corrugatus (Pennant 1777)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/44c-na9-47t
title: Trichoniscus pusillus Brandt 1833

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/mfm-wn5-edg
title: Callianassa plantei Sakai 2004

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/p0z-ke0-trf
title: Crangon allmanni Kinahan 1857

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/xkh-gys-ewe
title: Crangon allmanni Kinahan 1857

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/fbg-peh-d8h
title: Dilocarcinus pagei Stimpson 1861

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/x0w-0az-z7n
title: Chaceon maritae (Manning & Holthuis 1981)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/2d8-l2y-eel
title: Crangon allmanni Kinahan 1857

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/5xv-my7-2dc
title: Calliax sp.

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.
DOI: 10.3535/r2b-55e-mzq
title: Philoscia muscorum (Scopoli 1763)

description: Digital Specimen for the physical specimen hosted at Senckenberg Research Institute and Natural History Museum Frankfurt/M.