cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11708283
title: An IAEA survey of radiotherapy practice including quality assurance extent and depth

description: <b>Background:</b> The IAEA recommends a quality assurance program in radiotherapy to ensure safe and effective treatments. In this study, radiotherapy departments were surveyed on their current practice including the extent and depth of quality assurance activities. <b>Methods:</b> Radiotherapy departments were voluntarily surveyed in three stages, firstly, in basic facility information, secondly, in quality assurance activities and treatment techniques, and thirdly, in a snapshot of quality assurance, departmental and treatment activities. <b>Results:</b> The IAEA received completed surveys from 381 radiotherapy departments throughout the world with 100 radiotherapy departments completing all three surveys. Dominant patterns were found in linac-based radiotherapy with access to treatment planning systems for 3D-CRT and 3D imaging. Staffing levels for major staff groups were on average in the range recommended by the IAEA. The modal patient workload per EBRT unit was as expected in the range of 21–30 patients per day, however significant instances of high workload (more than 50 patients per day per treatment unit) were reported. Staffing levels were found to correlate with amount of treatment equipment and patient workload. In a self-assessment of quality assurance performance, most radiotherapy departments reported that they would perform at least 60% of the quality assurance activities itemized in the second survey, with particular strength in equipment quality control. In a snapshot survey of quality assurance performance, again equipment quality control practice was well developed, particularly for the treatment equipment. <b>Conclusions:</b> The IAEA surveys provide a snapshot of current radiotherapy practice including quality assurance activities.
DOI: 10.6084/m9.figshare.11708280
title: Supplementary Material for: Renal Function Assessment Gap in Clinical Practice: An Awkward Truth

description: <b><i>Introduction:</i></b> An accurate assessment of renal function is needed in the majority of clinical settings. Unfortunately, the most used estimated glomerular filtration rate (eGFR) formulas are affected by significant errors in comparison to gold standards methods of measured GFR (mGFR). <b><i>Objective:</i></b> The objective of the study is to determine the extent of the error of eGFR formulas compared to the mGFR in different specific clinical settings. <b><i>Methods:</i></b> A total retrospectively consecutive cohort of 1,320 patients (pts) enrolled in 2 different European Hospitals (Center 1: 470 pts; Center 2: 850 pts) was collected in order to compare the most common eGFR formulas used by physicians with the most widespread mGFR methods in daily clinical practice (Iohexol Plasma Clearance -Center 1 [mGFR-iox] and Renal Scintigraphy -Center 2 [mGFR-scnt]). The study cohort was composed by urological, oncological, and nephrological pts. The agreement between eGFR and mGFR was evaluated using bias (as median of difference), precision (as interquartile range of difference) accuracy (as P<sub>30</sub>), and total deviation index. <b><i>Results:</i></b> The most accurate eGFR formula in the comparison with gold standard method (Iohexol plasma clearance) in Center 1 was represented by s-creatinine and cystatin C combined Chronic Kidney Disease-Epidemiology Collaboration-cr-cy, even though the P<sub>30</sub> is reduced (84%) under the threshold of 60 mL/min/1.73 m<sup>2</sup>. Similar results were found in Center 2, with a wider discrepancy between mGFR-scnt and eGFR formulas due to the minor accuracy of the nuclear tool in respect to the mGFR-iox. <b><i>Conclusions:</i></b> The loss of accuracy observed for the formulas at lower values of GFR suggests the mandatory use of gold standards methods as Iohexol Plasma Clearance to assess the correct status of renal function for critical cases. The center 2 showed lower levels of agreement between mGFR and eGFR suggesting that the errors are partially accounted for the Renal Scintigraphy technique too. In particular, we suggest the use of mGFR-iox in oncological urological and nephrological pts with an eGFR lower than 60 mL/min/1.73 m<sup>2</sup>.
DOI: 10.6084/m9.figshare.11708283.v1
title: An IAEA survey of radiotherapy practice including quality assurance extent and depth

description: <b>Background:</b> The IAEA recommends a quality assurance program in radiotherapy to ensure safe and effective treatments. In this study, radiotherapy departments were surveyed on their current practice including the extent and depth of quality assurance activities. <b>Methods:</b> Radiotherapy departments were voluntarily surveyed in three stages, firstly, in basic facility information, secondly, in quality assurance activities and treatment techniques, and thirdly, in a snapshot of quality assurance, departmental and treatment activities. <b>Results:</b> The IAEA received completed surveys from 381 radiotherapy departments throughout the world with 100 radiotherapy departments completing all three surveys. Dominant patterns were found in linac-based radiotherapy with access to treatment planning systems for 3D-CRT and 3D imaging. Staffing levels for major staff groups were on average in the range recommended by the IAEA. The modal patient workload per EBRT unit was as expected in the range of 21–30 patients per day, however significant instances of high workload (more than 50 patients per day per treatment unit) were reported. Staffing levels were found to correlate with amount of treatment equipment and patient workload. In a self-assessment of quality assurance performance, most radiotherapy departments reported that they would perform at least 60% of the quality assurance activities itemized in the second survey, with particular strength in equipment quality control. In a snapshot survey of quality assurance performance, again equipment quality control practice was well developed, particularly for the treatment equipment. <b>Conclusions:</b> The IAEA surveys provide a snapshot of current radiotherapy practice including quality assurance activities.
DOI: 10.6084/m9.figshare.11708280.v1
title: Supplementary Material for: Renal Function Assessment Gap in Clinical Practice: An Awkward Truth

description: <b><i>Introduction:</i></b> An accurate assessment of renal function is needed in the majority of clinical settings. Unfortunately, the most used estimated glomerular filtration rate (eGFR) formulas are affected by significant errors in comparison to gold standards methods of measured GFR (mGFR). <b><i>Objective:</i></b> The objective of the study is to determine the extent of the error of eGFR formulas compared to the mGFR in different specific clinical settings. <b><i>Methods:</i></b> A total retrospectively consecutive cohort of 1,320 patients (pts) enrolled in 2 different European Hospitals (Center 1: 470 pts; Center 2: 850 pts) was collected in order to compare the most common eGFR formulas used by physicians with the most widespread mGFR methods in daily clinical practice (Iohexol Plasma Clearance -Center 1 [mGFR-iox] and Renal Scintigraphy -Center 2 [mGFR-scnt]). The study cohort was composed by urological, oncological, and nephrological pts. The agreement between eGFR and mGFR was evaluated using bias (as median of difference), precision (as interquartile range of difference) accuracy (as P<sub>30</sub>), and total deviation index. <b><i>Results:</i></b> The most accurate eGFR formula in the comparison with gold standard method (Iohexol plasma clearance) in Center 1 was represented by s-creatinine and cystatin C combined Chronic Kidney Disease-Epidemiology Collaboration-cr-cy, even though the P<sub>30</sub> is reduced (84%) under the threshold of 60 mL/min/1.73 m<sup>2</sup>. Similar results were found in Center 2, with a wider discrepancy between mGFR-scnt and eGFR formulas due to the minor accuracy of the nuclear tool in respect to the mGFR-iox. <b><i>Conclusions:</i></b> The loss of accuracy observed for the formulas at lower values of GFR suggests the mandatory use of gold standards methods as Iohexol Plasma Clearance to assess the correct status of renal function for critical cases. The center 2 showed lower levels of agreement between mGFR and eGFR suggesting that the errors are partially accounted for the Renal Scintigraphy technique too. In particular, we suggest the use of mGFR-iox in oncological urological and nephrological pts with an eGFR lower than 60 mL/min/1.73 m<sup>2</sup>.
DOI: 10.6084/m9.figshare.11708277.v1
title: Data and script for "Functional diversity metrics using kernel density n-dimensional hypervolumes"

description: Database and script to generate the example of functional diversity analysis based on n-dimensional hypervolumes with BAT.<br>Cardoso, P., Mammola, S., Rigal, F., & Carvalho, J. C. (2020). BAT: Biodiversity Assessment Tools. Retrieved from https://cran.r-project.org/package=BAT<br>Mammola, S., Cardoso, P. (2020) Functional diversity metrics using kernel density n-dimensional hypervolumes. bioRxiv, https://doi.org/10.1101/2020.01.25.919373<br>The example is based on the study:<br><br>Piano, E., Giuliano, D., & Isaia, M. (2020). Islands in cities: urbanization and fragmentation drive taxonomic and functional variation in ground arthropods. <i>Basic and Applied Ecology</i>.<br><br>
DOI: 10.6084/m9.figshare.11708277.v2
title: Data and script for "Functional diversity metrics using kernel density n-dimensional hypervolumes"

description: Database and script to generate the example of functional diversity analysis based on n-dimensional hypervolumes with BAT.<br>Cardoso, P., Mammola, S., Rigal, F., & Carvalho, J. C. (2020). BAT: Biodiversity Assessment Tools. Retrieved from https://cran.r-project.org/package=BAT<br>Mammola, S., Cardoso, P. (2020) Functional diversity metrics using kernel density n-dimensional hypervolumes. bioRxiv, https://doi.org/10.1101/2020.01.25.919373<br>The example is based on the study:<br><br>Piano, E., Giuliano, D., & Isaia, M. (2020). Islands in cities: urbanization and fragmentation drive taxonomic and functional variation in ground arthropods. <i>Basic and Applied Ecology, </i>43:86-98. https://doi.org/10.1016/j.baae.2020.02.001<br>
DOI: 10.6084/m9.figshare.11708244
title: Supplementary Material for: Characterizing Health Outcomes in Idiopathic Pulmonary Fibrosis using US Health Claims Data

description: <b><i>Background:</i></b> Idiopathic pulmonary fibrosis (IPF) is a life-threatening interstitial lung disease (ILD). Characterizing health outcomes of IPF patients is challenging due to disease rarity. <b><i>Objective:</i></b> This study aimed to identify the burden of disease in patients newly diagnosed with IPF. <b><i>Methods:</i></b> Patients with ≥1 claim with an IPF diagnosis were identified from a United States healthcare insurer’s database (2000–2013). Patients with other known causes of ILD or aged &lt;40 years were excluded. Subgroups were compared based on the 2011 change in International Classification of Diseases, 9th Revision (ICD-9) definition of IPF and occurrence of IPF testing. The prevalence and incidence of preselected health conditions of clinical interest were estimated. <b><i>Results:</i></b> Median age of newly diagnosed patients (<i>n</i> = 7,298) was 62 years (54.0% male). Restricting to patients with IPF diagnostic testing did not substantially affect cohort characteristics, nor did ICD-9 IPF coding change. Mean follow-up was 1.7 years; 16.8% of patients died; and a substantial proportion of patients were censored due to end of health plan enrollment (50.7%) and other causes of ILD (19.6%). The incidence of pulmonary hypertension, lung cancer, and claims-based algorithm proxy for acute respiratory worsening of unknown cause was 22.5, 17.6, and 12.6 per 1,000 person-years, respectively. <b><i>Conclusions:</i></b> Patients with IPF had a high disease burden with a variety of health outcomes observed, including a high rate of mortality. Database censoring due to changes in enrollment or other ILD diagnoses limited follow-up. Altering cohort entry definitions, including IPF testing or ICD-9 IPF coding change, had little impact on cohort baseline characteristics.
DOI: 10.6084/m9.figshare.11708244.v1
title: Supplementary Material for: Characterizing Health Outcomes in Idiopathic Pulmonary Fibrosis using US Health Claims Data

description: <b><i>Background:</i></b> Idiopathic pulmonary fibrosis (IPF) is a life-threatening interstitial lung disease (ILD). Characterizing health outcomes of IPF patients is challenging due to disease rarity. <b><i>Objective:</i></b> This study aimed to identify the burden of disease in patients newly diagnosed with IPF. <b><i>Methods:</i></b> Patients with ≥1 claim with an IPF diagnosis were identified from a United States healthcare insurer’s database (2000–2013). Patients with other known causes of ILD or aged &lt;40 years were excluded. Subgroups were compared based on the 2011 change in International Classification of Diseases, 9th Revision (ICD-9) definition of IPF and occurrence of IPF testing. The prevalence and incidence of preselected health conditions of clinical interest were estimated. <b><i>Results:</i></b> Median age of newly diagnosed patients (<i>n</i> = 7,298) was 62 years (54.0% male). Restricting to patients with IPF diagnostic testing did not substantially affect cohort characteristics, nor did ICD-9 IPF coding change. Mean follow-up was 1.7 years; 16.8% of patients died; and a substantial proportion of patients were censored due to end of health plan enrollment (50.7%) and other causes of ILD (19.6%). The incidence of pulmonary hypertension, lung cancer, and claims-based algorithm proxy for acute respiratory worsening of unknown cause was 22.5, 17.6, and 12.6 per 1,000 person-years, respectively. <b><i>Conclusions:</i></b> Patients with IPF had a high disease burden with a variety of health outcomes observed, including a high rate of mortality. Database censoring due to changes in enrollment or other ILD diagnoses limited follow-up. Altering cohort entry definitions, including IPF testing or ICD-9 IPF coding change, had little impact on cohort baseline characteristics.
DOI: 10.6084/m9.figshare.11708277.v3
title: Data and script for "Functional diversity metrics using kernel density n-dimensional hypervolumes"

description: Database and script to generate the example of functional diversity analysis based on n-dimensional hypervolumes with BAT (v. 2.0.1).<br>Cardoso, P., Mammola, S., Rigal, F., & Carvalho, J. C. (2020). BAT: Biodiversity Assessment Tools. Retrieved from https://cran.r-project.org/package=BAT<br>Full details and description is found in:<br>Mammola, S., Cardoso, P. (2020) Functional diversity metrics using kernel density n-dimensional hypervolumes. bioRxiv, https://doi.org/10.1101/2020.01.25.919373<br>The dataset used is based on the study:<br><br>Piano, E., Giuliano, D., & Isaia, M. (2020). Islands in cities: urbanization and fragmentation drive taxonomic and functional variation in ground arthropods. <i>Basic and Applied Ecology, </i>43:86-98. https://doi.org/10.1016/j.baae.2020.02.001<br>
DOI: 10.6084/m9.figshare.11708277.v4
title: Data and script for "Functional diversity metrics using kernel density n-dimensional hypervolumes"

description: Database and script to generate the example of functional diversity analysis based on n-dimensional hypervolumes with BAT (v. 2.0.1).<br>Cardoso, P., Mammola, S., Rigal, F., & Carvalho, J. C. (2020). BAT: Biodiversity Assessment Tools. Retrieved from https://cran.r-project.org/package=BAT<br>Full details and description is found in:<br>Mammola, S., Cardoso, P. (2020) Functional diversity metrics using kernel density n-dimensional hypervolumes. bioRxiv, https://doi.org/10.1101/2020.01.25.919373<br>The dataset used is based on the study:<br><br>Piano, E., Giuliano, D., & Isaia, M. (2020). Islands in cities: urbanization and fragmentation drive taxonomic and functional variation in ground arthropods. <i>Basic and Applied Ecology, </i>43:86-98. https://doi.org/10.1016/j.baae.2020.02.001<br>
DOI: 10.6084/m9.figshare.11708220
title: Experimental Data from Disentangling non-specific and specific transgenerational immune priming components in host–parasite interactions

description: Data of the infection status of offspring Daphnia in the control, and the three exposed treatment groups
DOI: 10.6084/m9.figshare.11708220.v1
title: Experimental Data from Disentangling non-specific and specific transgenerational immune priming components in host–parasite interactions

description: Data of the infection status of offspring Daphnia in the control, and the three exposed treatment groups
DOI: 10.6084/m9.figshare.11708205
title: R code from Long-term memory for a learned behaviour in a wild bird

description: Contains the code used for the analyses.
DOI: 10.6084/m9.figshare.11708205.v1
title: R code from Long-term memory for a learned behaviour in a wild bird

description: Contains the code used for the analyses.
DOI: 10.6084/m9.figshare.11708199
title: Dataset from Long-term memory for a learned behaviour in a wild bird

description: Contains the data supporting this article.
DOI: 10.6084/m9.figshare.11708184
title: Almedin Ljajic Basics of C# programming Certificate

description: Almedin Ljajic Basics of C# programming Certificate"Autumn Coding School 2019"<br>
DOI: 10.6084/m9.figshare.11708169
title: Supplementary Material for: Synergistic Effects of the 308-nm Excimer Light and Topical Calcipotriol for the Treatment of Chronic Hand Eczema: A Randomized Controlled Study

description: <b><i>Background:</i></b> Though topical corticosteroid is a standard treatment for chronic hand eczema (CHE), it can cause many adverse effects. Topical calcipotriol and monochromatic 308-nm excimer light (MEL) are new alternative therapies for several dermatoses, including CHE. <b><i>Objective:</i></b> This study aims to compare the efficacy of the combination of MEL and topical calcipotriol versus topical calcipotriol alone. <b><i>Methods:</i></b> One hand of the participants was randomly assigned to be irradiated with MEL twice weekly and topical calcipotriol applied twice daily while the other hand was assigned to receive only topical calcipotriol twice daily for 8 weeks. Then, only petrolatum ointment was applied during the 4-week follow-up period. Hand Eczema Severity Index (HECSI) and modified Total Lesion Symptom Score were assessed by a blinded investigator, and a visual analogue scale score of itching symptoms was graded by the participants. <b><i>Results:</i></b> In total, 36 hands from 18 subjects completed the protocol. On the combination-treated sides, the mean HECSI score was significantly reduced by 25% (<i>p</i> = 0.015) from the 4th week. Then, it was gradually decreased to 57 and 65% (<i>p</i> &lt; 0.001) at the 8th week and at the follow-up visit, respectively. For the monotherapy-treated sides, the mean HECSI score was reduced to 41% (<i>p</i> = 0.001) and 49% (<i>p</i> &lt; 0.001) at the 8th and 12th week, accordingly. At the end of the treatment period, itching scores were significantly decreased by around 64% (<i>p</i> &lt; 0.001) and 51% (<i>p</i> = 0.002) on the combination-treated and the monotherapy-treated sides. No serious and persistent adverse reactions were found. <b><i>Conclusion:</i></b> The combined MEL and topical calcipotriol may be considered as an alternatively effective treatment for CHE.
DOI: 10.6084/m9.figshare.11708139
title: Patient 7 for Tony

description: Patient 7 3T MRI datasets
DOI: 10.6084/m9.figshare.11708139.v1
title: Patient 7 for Tony

description: Patient 7 3T MRI datasets
DOI: 10.6084/m9.figshare.11708076
title: Supplementary Data from Modular footwear that partially offsets downhill or uphill grades minimizes the metabolic cost of human walking

description: Walking on different grades becomes challenging on energetic and muscular levels compared to level walking. While it is not possible to eliminate the cost of raising or lowering the centre of mass (COM), it could be possible to minimize the cost of distal joints with shoes that offset downhill or uphill grades. We investigated the effects of shoe outsole geometry in 10 participants walking at 1 m s<sup>−1</sup> on downhill, level and uphill grades. Level shoes minimized metabolic rate during level walking (<i>P</i><sub>second-order effect</sub> P<sub>interaction effect</sub> = 0.023). Shoe inclination influenced (distal) ankle joint parameters, including soleus muscle activity, ankle moment and work rate, whereas treadmill grade influenced (whole-body) ground reaction force and COM work rate as well as (distal) ankle joint parameters including tibialis anterior and plantarflexor muscle activity, ankle moment and work rate. Similar modular footwear could be used to minimize joint loads or assist with walking on rolling terrain.
DOI: 10.6084/m9.figshare.11707932
title: CIS_FINAL_data.csv

description: This data was collected for an online social network experiment, using a subject pool from Amazon Turk.
DOI: 10.6084/m9.figshare.11708076.v1
title: Supplementary Data from Modular footwear that partially offsets downhill or uphill grades minimizes the metabolic cost of human walking

description: Walking on different grades becomes challenging on energetic and muscular levels compared to level walking. While it is not possible to eliminate the cost of raising or lowering the centre of mass (COM), it could be possible to minimize the cost of distal joints with shoes that offset downhill or uphill grades. We investigated the effects of shoe outsole geometry in 10 participants walking at 1 m s<sup>−1</sup> on downhill, level and uphill grades. Level shoes minimized metabolic rate during level walking (<i>P</i><sub>second-order effect</sub> P<sub>interaction effect</sub> = 0.023). Shoe inclination influenced (distal) ankle joint parameters, including soleus muscle activity, ankle moment and work rate, whereas treadmill grade influenced (whole-body) ground reaction force and COM work rate as well as (distal) ankle joint parameters including tibialis anterior and plantarflexor muscle activity, ankle moment and work rate. Similar modular footwear could be used to minimize joint loads or assist with walking on rolling terrain.
DOI: 10.6084/m9.figshare.11707932.v1
title: CIS_FINAL_data.csv

description: This data was collected for an online social network experiment, using a subject pool from Amazon Turk.
DOI: 10.6084/m9.figshare.11707293
title: MOESM3 of A rapid quality control test to foster the development of the sterile insect technique against Anopheles arabiensis

description: Additional file 3. Temperature experiments raw data.
DOI: 10.6084/m9.figshare.11707293.v1
title: MOESM3 of A rapid quality control test to foster the development of the sterile insect technique against Anopheles arabiensis

description: Additional file 3. Temperature experiments raw data.
DOI: 10.6084/m9.figshare.11707281
title: MOESM2 of A rapid quality control test to foster the development of the sterile insect technique against Anopheles arabiensis

description: Additional file 2. Irradiation experiments raw data.
DOI: 10.6084/m9.figshare.11707281.v1
title: MOESM2 of A rapid quality control test to foster the development of the sterile insect technique against Anopheles arabiensis

description: Additional file 2. Irradiation experiments raw data.
DOI: 10.6084/m9.figshare.11707278
title: MOESM1 of A rapid quality control test to foster the development of the sterile insect technique against Anopheles arabiensis

description: Additional file 1. Compaction experiments raw data.
DOI: 10.6084/m9.figshare.11707278.v1
title: MOESM1 of A rapid quality control test to foster the development of the sterile insect technique against Anopheles arabiensis

description: Additional file 1. Compaction experiments raw data.