cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5255/ukda-sn-857059
title: Anti-Fracking Protest Events in England, 2011-2019

description: This data contains information about the number of ‘conventional’ and ‘non-conventional’ protest events during the anti-fracking campaigns in England, by year and county. Years cover the campaign period from its beginning in 2011 until the nationwide moratorium announced by the UK Government in 2019, with protest events from October 2011 until March 2019 captured. The counties represent three different contexts in which community-based mobilisation against fracking was seen; namely, Lancashire alongside North and South Yorkshire. Numerous other variables are provided, including socio-economic and industry-specific data. UK-level data is also included and the variables represent a mix of data forms, especially of a binary nature.

The data provides an important window into the English anti-fracking campaigns that were community-led, inclusive of surrounding contextual factors. It is of interest for studies of this timeframe, industry and mobilisation both as a standalone dataset and for complementary use alongside other datasets. The dataset lends itself to comparative, time-series cross-sectional analyses at the intersection between local socio-political and economic contexts, and community-based anti-fracking mobilisation.
DOI: 10.57967/hf/1947
title: dreambooth-cell-images
DOI: 10.6084/m9.figshare.24942245
title: Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice

description: The activation of the NLRP3 inflammasome has been implicated in male infertility. Our study aimed to investigate the therapeutic role of Thiolutin (THL), an inhibitor of the NLRP3 inflammasome, on oligoasthenospermia (OA) and to elucidate its mechanisms. Semen from 50 OA and 20 healthy males were analyzed to assess the sperm quality and levels of inflammatory markers. Their correlation was determined using Pearson’s correlation coefficient. The BALB/c mice were intraperitoneal injected by cyclophosphamide at 60 mg/kg/day for five days to induce OA, followed by a two-week treatment with THL or L-carnitine. Reproductive organ size and H&E staining were determined to observe the organ and seminiferous tubule morphology. ELISA and western blotting were utilized to measure sex hormone levels, inflammatory markers, and NLRP3 inflammasome levels. Furthermore, male and female mice were co-housed to observe pregnancy success rates. OA patients exhibited a decrease in sperm density and motility compared to healthy individuals, along with elevated levels of IL-1β, IL-18 and NLRP3 inflammasome. <i>In vivo</i>, THL ameliorated OA-induced atrophy of reproductive organs, hormonal imbalance, and improved sperm density, motility, spermatogenesis and pregnancy success rates with negligible adverse effects on weight or liver-kidney function. THL also demonstrated to be able to inhibit the activation of NLRP3 inflammasome and associated proteins in OA mice. THL can improve sperm quality and hormonal balance in OA mice through the inhibition of NLRP3 inflammasome activation. Thus, THL holds promising potential as a therapeutic agent for OA.
DOI: 10.6084/m9.figshare.24942245.v1
title: Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice

description: The activation of the NLRP3 inflammasome has been implicated in male infertility. Our study aimed to investigate the therapeutic role of Thiolutin (THL), an inhibitor of the NLRP3 inflammasome, on oligoasthenospermia (OA) and to elucidate its mechanisms. Semen from 50 OA and 20 healthy males were analyzed to assess the sperm quality and levels of inflammatory markers. Their correlation was determined using Pearson’s correlation coefficient. The BALB/c mice were intraperitoneal injected by cyclophosphamide at 60 mg/kg/day for five days to induce OA, followed by a two-week treatment with THL or L-carnitine. Reproductive organ size and H&E staining were determined to observe the organ and seminiferous tubule morphology. ELISA and western blotting were utilized to measure sex hormone levels, inflammatory markers, and NLRP3 inflammasome levels. Furthermore, male and female mice were co-housed to observe pregnancy success rates. OA patients exhibited a decrease in sperm density and motility compared to healthy individuals, along with elevated levels of IL-1β, IL-18 and NLRP3 inflammasome. <i>In vivo</i>, THL ameliorated OA-induced atrophy of reproductive organs, hormonal imbalance, and improved sperm density, motility, spermatogenesis and pregnancy success rates with negligible adverse effects on weight or liver-kidney function. THL also demonstrated to be able to inhibit the activation of NLRP3 inflammasome and associated proteins in OA mice. THL can improve sperm quality and hormonal balance in OA mice through the inhibition of NLRP3 inflammasome activation. Thus, THL holds promising potential as a therapeutic agent for OA.
DOI: 10.6084/m9.figshare.25026775
title: Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis

description: Ulcerative colitis (UC) is an inflammatory intestine disease characterized by dysfunction of the intestinal mucosal barrier, ferroptosis, and apoptosis. Previous researches suggest that celecoxib, a nonsteroidal anti-inflammatory drug, holds promise in alleviating inflammation in UC. Therefore, this study aims to investigate the effects and mechanisms of celecoxib in UC. To identify ferroptosis-related drugs and genes associated with UC, we utilized the Gene Expression Omnibus (GEO), FerrDb databases, and DGIdb database. Subsequently, we established a 2.5% DSS (Dextran sulfate sodium)-induced colitis model in mice and treated them with 10 mg/kg of celecoxib to validate the bioinformatics results. We evaluated histological pathologies, inflammatory response, intestinal barrier function, ferroptosis markers, and apoptosis regulators. Celecoxib treatment significantly ameliorated DSS-induced UC in mice, as evidenced by the body weight change curve, colon length change curve, disease activity index (DAI) score, and histological index score. Celecoxib treatment reduced the level of pro-inflammatory factors and promoted the expressions of intestinal tight junction proteins such as Claudin-1 and Occludin, thereby restoring the integrity of the intestinal mucosal barrier. Furthermore, celecoxib treatment reversed the ferroptosis characteristics in DSS-induced mice by increasing glutathione (GSH), decreasing malondialdehyde (MDA), and increasing the expression of GPX-4 and xCT. Additionally, apoptosis was induced in mice with UC, as evidenced by increased Caspase3, BAD, P53, BAX, Caspase9 and Aifm1 production, and decreased expression of BCL-XL and BCL2. Celecoxib treatment significantly reversed the apoptotic changes in DSS-induced mice. Our findings suggest that celecoxib effectively treats DSS-induced UC in mice by inhibiting ferroptosis and apoptosis. Celecoxib enhancing intestinal barrier functionCelecoxib alleviates ferroptosis in DSS-induces ulcerative colitisCelecoxib effectively alleviates apoptosis signaling pathway Celecoxib enhancing intestinal barrier function Celecoxib alleviates ferroptosis in DSS-induces ulcerative colitis Celecoxib effectively alleviates apoptosis signaling pathway
DOI: 10.6084/m9.figshare.25026775.v1
title: Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis

description: Ulcerative colitis (UC) is an inflammatory intestine disease characterized by dysfunction of the intestinal mucosal barrier, ferroptosis, and apoptosis. Previous researches suggest that celecoxib, a nonsteroidal anti-inflammatory drug, holds promise in alleviating inflammation in UC. Therefore, this study aims to investigate the effects and mechanisms of celecoxib in UC. To identify ferroptosis-related drugs and genes associated with UC, we utilized the Gene Expression Omnibus (GEO), FerrDb databases, and DGIdb database. Subsequently, we established a 2.5% DSS (Dextran sulfate sodium)-induced colitis model in mice and treated them with 10 mg/kg of celecoxib to validate the bioinformatics results. We evaluated histological pathologies, inflammatory response, intestinal barrier function, ferroptosis markers, and apoptosis regulators. Celecoxib treatment significantly ameliorated DSS-induced UC in mice, as evidenced by the body weight change curve, colon length change curve, disease activity index (DAI) score, and histological index score. Celecoxib treatment reduced the level of pro-inflammatory factors and promoted the expressions of intestinal tight junction proteins such as Claudin-1 and Occludin, thereby restoring the integrity of the intestinal mucosal barrier. Furthermore, celecoxib treatment reversed the ferroptosis characteristics in DSS-induced mice by increasing glutathione (GSH), decreasing malondialdehyde (MDA), and increasing the expression of GPX-4 and xCT. Additionally, apoptosis was induced in mice with UC, as evidenced by increased Caspase3, BAD, P53, BAX, Caspase9 and Aifm1 production, and decreased expression of BCL-XL and BCL2. Celecoxib treatment significantly reversed the apoptotic changes in DSS-induced mice. Our findings suggest that celecoxib effectively treats DSS-induced UC in mice by inhibiting ferroptosis and apoptosis. Celecoxib enhancing intestinal barrier functionCelecoxib alleviates ferroptosis in DSS-induces ulcerative colitisCelecoxib effectively alleviates apoptosis signaling pathway Celecoxib enhancing intestinal barrier function Celecoxib alleviates ferroptosis in DSS-induces ulcerative colitis Celecoxib effectively alleviates apoptosis signaling pathway
DOI: 10.5255/ukda-sn-857052
title: Focus Group Discussion Data for Evaluating the Sustainability and Transferability of the Delegated Management Model of Urban Water Services in Kenya, Kisumu, 2023

description: This qualitative data set comprises transcripts from focus group discussions (FGDs) with small-scale water service providers and their customers in Kisumu, Kenya. The study aims to assess the long-term sustainability, transferability and potential for scale-up of Kisumu’s Delegated Management Model (DMM) of water service delivery. DMM devolves responsibility for localized water service delivery from a utility to micro-enterprises or community-based organisations, known as Master Operators. This qualitative study was part of a sequential explanatory mixed methods study, particularly seeking explanations for patterns in water interruptions and pricing identified via an earlier questionnaire survey in the same communities. FGDs were conducted with two groups each of kiosk operators and water consumers in both DMM areas and matching control areas. Additionally, in DMM areas only, FGDs were also conducted with Master Operators. In total, this gave ten FGDs with an average of ten participants in each one. FGDs consisted of a series of open-ended questions that examined potential barriers to sustainability and scale-up, possible drivers of issues such as water pricing and supply interruptions, as well as the scheme’s potential to be applied to delivery of other services, such as wastewater or solid waste collection. FGDs were audio-recorded, then transcribed, translated in some parts from Dholuo or Kiswahili into English, and anonymized prior to being made available as this data set.
DOI: 10.5519/qd.1j7uvbio
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (5800606 records)
DOI: 10.4121/3a5eb5a8-bbae-4dd9-9a8d-d621bc1e36d2
title: Data accompanying the doctoral thesis "Advancing non-rigid 3D/4D human mesh registration for ultra personalization"

description: This dataset includes all the data and codes used in the doctoral thesis "Advancing non-rigid 3D/4D human mesh registration for ultra personalization", which contains six sections corresponding to each technical chapter (6 chapters in total from chapter 2 to chapter 7). Sections 1, and 2, discuss 3D non-rigid registration methods including datasets of human feet, full human body, and the human spine. Section 3 presents a volumetric detailed human body spine. Section 4 introduces a MATLAB code for designing an optimal scanner using Intel Realsense depth cameras. Sections 5 and 6 include a 4D dataset of walking human complete feet.
DOI: 10.4121/3a5eb5a8-bbae-4dd9-9a8d-d621bc1e36d2.v1
title: Data accompanying the doctoral thesis "Advancing non-rigid 3D/4D human mesh registration for ultra personalization"

description: This dataset includes all the data and codes used in the doctoral thesis "Advancing non-rigid 3D/4D human mesh registration for ultra personalization", which contains six sections corresponding to each technical chapter (6 chapters in total from chapter 2 to chapter 7). Sections 1, and 2, discuss 3D non-rigid registration methods including datasets of human feet, full human body, and the human spine. Section 3 presents a volumetric detailed human body spine. Section 4 introduces a MATLAB code for designing an optimal scanner using Intel Realsense depth cameras. Sections 5 and 6 include a 4D dataset of walking human complete feet.
DOI: 10.5281/zenodo.10853120
title: Dataset for "Speciation of Lanthanide Metal Ion Dopants in Microcrystalline All-Inorganic Halide Perovskite CsPbCl3"

description: Raw solid-state NMR and XRD data for "Speciation of Lanthanide Metal Ion Dopants in Microcrystalline All-Inorganic Halide Perovskite CsPbCl3"
DOI: 10.5281/zenodo.10853121
title: Dataset for "Speciation of Lanthanide Metal Ion Dopants in Microcrystalline All-Inorganic Halide Perovskite CsPbCl3"

description: Raw solid-state NMR and XRD data for "Speciation of Lanthanide Metal Ion Dopants in Microcrystalline All-Inorganic Halide Perovskite CsPbCl3"
DOI: 10.6084/m9.figshare.25449847
title: An empirical test of scale-dependence of β-diversity in a large temperate forest region

description: Data and code from: "An empirical test of scale-dependence of β-diversity in a large temperate forest region".
DOI: 10.6084/m9.figshare.25449847.v1
title: Scale-dependence of β-diversity patterns in a large temperate forest region

description: Data and code from: "Scale-dependence of β-diversity patterns in a large temperate forest region".
DOI: 10.5517/ccrtk03
title: CCDC 709745: Experimental Crystal Structure Determination

description: Related Article: Hong-Yan Lin, Hai-Liang Hu, Bao-Kuan Chen, Jin Li|2009|Guangpu Shiyanshi|26|803|
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.25459972
title: LSS vs DS Data.xlsx

description: This study aimed to examine the vertebral body shape characteristics and spondylopelvic alignment in L4 degenerative spondylolisthesis (DS) as well as the risk factors for the development of DS.The study protocol was approved by our institutional review board (IRB) for clinical investigations and was conducted in accordance with the Declaration of Helsinki and the Health Insurance Portability and Accountability Act. Written informed consent was obtained from all participants and their parents. All study participants were recruited from the Division of Orthopaedic Surgery of our hospital. Our IRB approved this retrospective review of the patient data (approval number:2021-11-R-06). On February 20, 2022, access was obtained from a database containing records of spinal surgeries conducted at the hospital, and patient data were collected.<br>
DOI: 10.6084/m9.figshare.25459972.v1
title: LSS vs DS Data.xlsx

description: This study aimed to examine the vertebral body shape characteristics and spondylopelvic alignment in L4 degenerative spondylolisthesis (DS) as well as the risk factors for the development of DS.The study protocol was approved by our institutional review board (IRB) for clinical investigations and was conducted in accordance with the Declaration of Helsinki and the Health Insurance Portability and Accountability Act. Written informed consent was obtained from all participants and their parents. All study participants were recruited from the Division of Orthopaedic Surgery of our hospital. Our IRB approved this retrospective review of the patient data (approval number:2021-11-R-06). On February 20, 2022, access was obtained from a database containing records of spinal surgeries conducted at the hospital, and patient data were collected.<br>
DOI: 10.15468/aycpsg
title: Danish 19th Century Regional Floras

description: This dataset consists of records and regional occupancy values of all native and naturalized taxa of land plants (species, subspecies, forma, and varieties), in some cases vascular plants only, as reported by eleven regional floras, which were compiled – and all except one published – in the period 1857-1881. Each flora mainly reports occurrences recorded by the author, but some floras do report older published and unpublished records from their study area. The regional occupancy is typically rendered on a verbatim, semi-quantitative ordinal scale from very rare to very common, but for rarer taxa given as a number of occurrence sites or one or more named occurrence localities. Analysis of patterns of plant richness change based on the data is found in Finderup Nielsen et al. (2019).
DOI: 10.7488/ds/7700
title: Causes of Variation in Malaria Infection Dynamics: Insights from Theory and Data

description: Abstract Parasite strategies for exploiting host resources are key determinants of disease severity (i.e., virulence) and infectiousness (i.e., transmission between hosts). By iterating the development of theory and empirical tests, we investigated whether variation in parasite traits across two genetically distinct clones of the rodent malaria parasite, Plasmodium chabaudi, explains differences in within-host infection dynamics and virulence. First, we experimentally tested key predictions of our earlier modeling work. As predicted, the more virulent genotype produced more progeny parasites per infected cell (burst size), but in contrast to predictions, invasion rates of red blood cells (RBCs) did not differ between the genotypes studied. Second, we further developed theory by confronting our earlier model with these new data, testing a new set of models that incorporate more biological realism, and developing novel theoretical tools for identifying differences between parasite genotypes. Overall, we found robust evidence that differences in burst sizes contribute to variation in dynamics and that differential interactions between parasites and host immune responses also play a role. In contrast to previous work, our model predicts that RBC age structure is not important for explaining dynamics. Integrating theory and empirical tests is a potentially powerful way of progressing understanding of disease biology. Dataset: Measures of red blood cell and parasite densities for full experiment, manipulating immunity and resources in fully factorial design (not all data is presented in published paper)
description: Readme documentation including descriptions: README_Mideo2011AmNat.docx Dataset: Data_Mideo2011AmNat.csv
DOI: 10.5255/ukda-sn-856559
title: Interviews With Observers of and Participants in Dutch and UK Heat Transition Governance, 2021-2022

description: Going Dutch? was a 2-year research project, led from the University of Sussex and funded by the UK Energy Research Centre, comparing governance arrangements for heat decarbonisation and natural gas phase-out in the UK and the Netherlands and investigating how these arrangements have been shaped by different political and institutional context. The UK and the Netherlands share a similar starting point for heat decarbonisation in that they are the countries most dependent on natural gas for heating in Europe and the OECD. However, they have taken different approaches to their heat transitions so far, with the Netherlands giving a much more central role to local government (municipalities). There are also differences within the UK, with Scotland adopting a governance approach that is closer to the Netherlands than England, where heat transition governance remains highly centralised. The project aimed to understand how wider political, administrative and economic institutions have shaped these different governance approaches, what the experience of the Dutch approach has been to date, and what lessons there might be for the UK. The topics of study included: the nature of climate governance; the roles and capacities of local government; the structure of multi-level governance; mechanisms for knowledge-sharing and learning; allocation of resources; organisation of technical support and knowledge, and public engagement and participation. The collection includes anonymised interviews with 16 observers of and participants in attempts to decarbonise residential heating in the Netherlands and the UK. The interviews were conducted between December 2021 and September 2022, and the focus of the research was on the governance arrangements for heat decarbonisation.
DOI: 10.34658/rdb.qd2heb/nkxquy
title: 0V_FINAL.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/jdygsp
title: 1_25V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/ricwcd
title: 02V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/sgiqqg
title: 1_15V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/pbqfv7
title: 1_4V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/cqfqnu
title: 10V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/tzqube
title: 2_05V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/jnf9df
title: 2_0V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/pnqnw2
title: 12V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/u6m92g
title: 0_6V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/mfwxbs
title: 0V_PO12V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/2msxoz
title: 1_3V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/hwuxez
title: 08V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/gqktur
title: 1_05V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/sgu9hy
title: 14V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/oue5j4
title: 1_85V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/jz0l29
title: 1_4V_PO.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/sxyhz2
title: 2_15V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/w6eqwk
title: 0V_INIT.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/pdi7rg
title: 1_75V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/usodqj
title: 0V_PO175.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/zf71ul
title: 0_1V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/lvxluu
title: 0_4V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/anmt0n
title: 1_2V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/bs4hi5
title: 11V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/85zmye
title: 10V_INIT.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/85eho9
title: 1_75_PO.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/dtibe8
title: 1_9V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/dhbjuf
title: 12V_INIT.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/hwhefi
title: 0V_PO1_4.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/olci36
title: 1_1V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/xvfanh
title: 1_6V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/hihjeb
title: 1_45_PO.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/wwn9hw
title: 1_7V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/c0onah
title: 1_0V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/uf5xwi
title: 1_4WTF.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/cmreci
title: 0V_10MIN.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/5i8buj
title: 0V_PO1V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/w18bzl
title: 1_35V.WAV

description: :unav
DOI: 10.34658/rdb.qd2heb/3qy5wg
title: 0_2V.WAV

description: :unav