cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28103561.v1
title: Effects of gonadotropin-releasing hormone antagonist (GnRH-ant) cessation on trigger day in a GnRH-ant protocol: a meta-analysis

description: The gonadotropin-releasing hormone antagonist (GnRH-ant) protocol is associated with few oocytes retrieved, few mature oocytes and poor endometrial receptivity. Omission of GnRH-ants on trigger day seems unlikely to induce preovulation and may improve outcomes in the GnRH-ant protocol. This study aimed to systematically evaluate the effects of GnRH-ant cessation on trigger day on in vitro fertilisation outcomes following the GnRH-ant protocol. We searched PubMed, Ovid/MEDLINE, Wanfang, VIP, CNKI and ClinicalTrials.gov databases. The last search was conducted on 10 December 2023 in English or Chinese, without time limitations on the collection of studies from the databases. The references in these articles were manually searched. Randomised controlled trials (RCTs) and cohort studies aimed at assessing the effects of GnRH-ant cessation on trigger day using the GnRH-ant protocol were included. The eligible studies included at least one of the main outcomes: number of oocytes retrieved, proportion of mature oocytes, implantation rate or clinical pregnancy rate. Three studies with 1449 cycles were included. Cessation of GnRH-ant on trigger day improved the proportion of mature oocytes (odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.09–1.45, <i>I</i><sup>2</sup> = 0%) but did not affect the number of oocytes retrieved (mean difference [MD] = 0.50, 95% CI = −0.07 to 1.07, <i>I</i><sup>2</sup> = 47%), implantation rate (OR = 0.95, 95% CI = 0.69–1.30, <i>I</i><sup>2</sup> = 0%), clinical pregnancy rate (OR = 1.06, 95% CI = 0.71–1.58, <i>I</i><sup>2</sup> = 0%), endometrial thickness (MD = −0.09, 95% CI = −0.27 to 0.10, <i>I</i><sup>2</sup> = 0%) or cycle cancellation rate (OR = 0.64, 95% CI = 0.15–2.74, I<sup>2</sup> = 0%). Cessation of GnRH-ant on trigger day of the GnRH-ant protocol is suggested because it could improve the proportion of mature oocytes. However, further RCTs are required. The gonadotropin-releasing hormone antagonist (GnRH-ant) protocol is widely used to treat patients undergoing in vitro fertilisation. However, this protocol is associated with fewer oocytes retrieved, fewer mature oocytes and poorer endometrial receptivity than the depot gonadotropin-releasing hormone agonist protocol. The omission of GnRH-ants on trigger day seems unlikely to induce preovulation and may improve outcomes in the GnRH-ant protocol. This meta-analysis was performed to systematically evaluate the effects of cessation of GnRH-ants on trigger day in in vitro fertilisation outcomes following the GnRH-ant protocol. The cessation of GnRH-ants on trigger day improved the proportion of mature oocytes. It does not compromise the number of oocytes retrieved, implantation rate, clinical pregnancy rate or induction of preovulation. GnRH-ants should be omitted on trigger day of the GnRH-ant protocol during controlled ovarian hyperstimulation.
DOI: 10.48597/9k6z-7zkj
title: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)

description: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)
DOI: 10.48597/bemf-52ds
title: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)

description: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)
DOI: 10.6084/m9.figshare.29205876
title: What is currently known about female genital mutilation and incontinence: a narrative literature review

description: An estimated 230 million girls and women are living with female genital mutilation (FGM) which causes ongoing physical and psychological harm. This review aims to explore what is known about FGM and incontinence, including the underexamined implications for women’s health, and identify gaps in the literature. A comprehensive database search was conducted using MEDLINE, CINAHL Plus, APA Psych Info, AMED, Child Development and Adolescent Studies, and PubMed. To gather all relevant complications of FGM, no restrictions were imposed on date or study type. Themes were identified by organising the 20 eligible articles by symptom type. The findings indicate that urological symptoms such as dribbling incontinence, slow micturition, urgency, stress incontinence and overactive bladder are prevalent among women who have undergone FGM. Additional complications include fistulas, pelvic organ prolapse, somatic symptoms, and urinary tract infections. The impact of FGM and incontinence on quality of life and daily activities remains under-explored, with the lived experiences of affected women largely unreported. FGM has multiple urogynaecological consequences, with more severe forms causing increased symptoms and associated complications. This review highlights the need for further research into the biopsychosocial impacts of FGM and incontinence to provide evidence-based support for affected women. Female genital mutilation affects around 230 million girls and women worldwide and causes serious physical and psychological harm. This review looks at the connection between female genital mutilation and incontinence, how this affects women’s health, and finds areas that need more research. Multiple medical databases were searched for relevant studies; 20 were found. These studies showed that women with female genital mutilation often have urinary problems like leaking urine, slow urination, urgency, stress incontinence and over-active bladder. Other issues include fistulas, pelvic organ prolapse, psychological symptoms like post-traumatic stress disorder, and higher risk of urinary tract infections. Treatment includes repairing injured areas with plastic surgery, teaching techniques to recognise when the bladder is full or empty, and talking therapy. These treatments were found to be effective straight after surgery, or within a few months for non-surgical options. The impact of female genital mutilation and incontinence on daily life and quality of life is not well-studied. More research is needed to understand these effects and to provide better support for women with female genital mutilation.
DOI: 10.6084/m9.figshare.29205876.v1
title: What is currently known about female genital mutilation and incontinence: a narrative literature review

description: An estimated 230 million girls and women are living with female genital mutilation (FGM) which causes ongoing physical and psychological harm. This review aims to explore what is known about FGM and incontinence, including the underexamined implications for women’s health, and identify gaps in the literature. A comprehensive database search was conducted using MEDLINE, CINAHL Plus, APA Psych Info, AMED, Child Development and Adolescent Studies, and PubMed. To gather all relevant complications of FGM, no restrictions were imposed on date or study type. Themes were identified by organising the 20 eligible articles by symptom type. The findings indicate that urological symptoms such as dribbling incontinence, slow micturition, urgency, stress incontinence and overactive bladder are prevalent among women who have undergone FGM. Additional complications include fistulas, pelvic organ prolapse, somatic symptoms, and urinary tract infections. The impact of FGM and incontinence on quality of life and daily activities remains under-explored, with the lived experiences of affected women largely unreported. FGM has multiple urogynaecological consequences, with more severe forms causing increased symptoms and associated complications. This review highlights the need for further research into the biopsychosocial impacts of FGM and incontinence to provide evidence-based support for affected women. Female genital mutilation affects around 230 million girls and women worldwide and causes serious physical and psychological harm. This review looks at the connection between female genital mutilation and incontinence, how this affects women’s health, and finds areas that need more research. Multiple medical databases were searched for relevant studies; 20 were found. These studies showed that women with female genital mutilation often have urinary problems like leaking urine, slow urination, urgency, stress incontinence and over-active bladder. Other issues include fistulas, pelvic organ prolapse, psychological symptoms like post-traumatic stress disorder, and higher risk of urinary tract infections. Treatment includes repairing injured areas with plastic surgery, teaching techniques to recognise when the bladder is full or empty, and talking therapy. These treatments were found to be effective straight after surgery, or within a few months for non-surgical options. The impact of female genital mutilation and incontinence on daily life and quality of life is not well-studied. More research is needed to understand these effects and to provide better support for women with female genital mutilation.
DOI: 10.6084/m9.figshare.29424567
title: Menstrual management using hormonal medications in adolescents and young adults with developmental disability: a systematic review and a meta-analysis

description: Adolescents with developmental disability (DD) may experience similar menstrual disorders as their peers, as well as unique challenges associated with their underlying conditions. They have access to the same hormonal medications as the general population, but little is known about the effects of menstrual management in adolescents with DD. The aim of this study was to assess the efficacy, satisfaction with, side effects and complications of hormonal medications that are used for menstrual management in adolescents and young adults with DD. A systematic review was performed in Medline, Embase, Cochrane library and PsycNet, using keywords related to menstrual management, hormonal medications, adolescents and disability. Meta-analyses of proportions were conducted for outcomes that could be combined across studies. Of the 2088 articles identified, 20 studies were included. The total number of participants was 3317 and varied significantly across studies (from 14 to 1560 individuals). Menstrual management was associated with a reduction in bleeding and high rates of amenorrhoea. We found that 45.4% (95% CI, 32.1–59%) of levonorgestrel-intrauterine device users experienced amenorrhoea. Satisfaction was high with all methods and correlated with the reduction in bleeding. Breakthrough bleeding was the most common side effect and the primary reason for ceasing or switching medication. No case of venous thromboembolism was reported. Menstrual management was associated with improvement in menstrual symptoms and high levels of satisfaction in adolescents with DD. Side effects and complication rates were low in this population. This should support the use of menstrual management in adolescents with DD, who deserve similar access to menstrual health care as their peers. Menstrual management means using hormonal medications to reduce menstrual symptoms and, sometimes, completely stop periods. Little is known about the effects of menstrual management in adolescents with disability. The aim of this study was to assess the efficacy, satisfaction with, side effects and complications of medications that are used for menstrual management in adolescents with disability. We searched several databases and found 20 important studies. Menstrual management was associated with improvement in menstrual symptoms, and many patients had their periods stop completely. Patients were very satisfied with these medications, mainly because they reduced the amount of bleeding. Side effects and complication were rare in this population. These findings support the use of hormonal medications for menstrual management in adolescents with disability, who deserve similar access to menstrual health care as their peers.
DOI: 10.6084/m9.figshare.29424567.v1
title: Menstrual management using hormonal medications in adolescents and young adults with developmental disability: a systematic review and a meta-analysis

description: Adolescents with developmental disability (DD) may experience similar menstrual disorders as their peers, as well as unique challenges associated with their underlying conditions. They have access to the same hormonal medications as the general population, but little is known about the effects of menstrual management in adolescents with DD. The aim of this study was to assess the efficacy, satisfaction with, side effects and complications of hormonal medications that are used for menstrual management in adolescents and young adults with DD. A systematic review was performed in Medline, Embase, Cochrane library and PsycNet, using keywords related to menstrual management, hormonal medications, adolescents and disability. Meta-analyses of proportions were conducted for outcomes that could be combined across studies. Of the 2088 articles identified, 20 studies were included. The total number of participants was 3317 and varied significantly across studies (from 14 to 1560 individuals). Menstrual management was associated with a reduction in bleeding and high rates of amenorrhoea. We found that 45.4% (95% CI, 32.1–59%) of levonorgestrel-intrauterine device users experienced amenorrhoea. Satisfaction was high with all methods and correlated with the reduction in bleeding. Breakthrough bleeding was the most common side effect and the primary reason for ceasing or switching medication. No case of venous thromboembolism was reported. Menstrual management was associated with improvement in menstrual symptoms and high levels of satisfaction in adolescents with DD. Side effects and complication rates were low in this population. This should support the use of menstrual management in adolescents with DD, who deserve similar access to menstrual health care as their peers. Menstrual management means using hormonal medications to reduce menstrual symptoms and, sometimes, completely stop periods. Little is known about the effects of menstrual management in adolescents with disability. The aim of this study was to assess the efficacy, satisfaction with, side effects and complications of medications that are used for menstrual management in adolescents with disability. We searched several databases and found 20 important studies. Menstrual management was associated with improvement in menstrual symptoms, and many patients had their periods stop completely. Patients were very satisfied with these medications, mainly because they reduced the amount of bleeding. Side effects and complication were rare in this population. These findings support the use of hormonal medications for menstrual management in adolescents with disability, who deserve similar access to menstrual health care as their peers.
DOI: 10.48597/bttv-9eqz
title: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)

description: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)
DOI: 10.6084/m9.figshare.30601546
title: Uterocervical angle as a predictor for spontaneous singleton preterm birth: a prospective observational study

description: The use of cervical length (CL) to predict spontaneous preterm birth (sPTB) is limited in performance due to the low prevalence of a short cervix in the Thai population. Therefore, this study aims to evaluate the diagnostic performance of the uterocervical angle (UCA) in comparison with CL, and the integration of these parameters alongside cervical wedging to predict sPTB. This prospective cohort study was designed to assess the diagnostic performance of UCA, CL, and cervical wedging for sPTB in singleton pregnancies, between gestational ages of 16 and 24 weeks, using transvaginal ultrasonography. The primary outcome was the diagnostic performance of the UCA, along with the integration of UCA with other parameters in women who delivered before 37 and 34 weeks. A total of 261 participants were included in the analysis. The optimal cut-off value for predicting sPTB before 37 weeks was 85 degrees for UCA, with a sensitivity of 44.8%, specificity of 46.6%, and a diagnostic odds ratio (DOR) of 0.71. For predicting sPTB before 34 weeks, the optimal cut-off for UCA was found to be 95 degrees, with a sensitivity of 71.4%, specificity of 59.8%, and a DOR of 3.73. The integration of UCA with CL or cervical wedging did not yield superior results compared to CL alone. The area under the receiver operating characteristic curve showed that UCA over 85 degrees was not as effective as CL under 33 mm for predicting sPTB before 37 weeks (0.54 vs. 0.51, respectively). However, CL under 30 mm was better than UCA over 95 degrees at predicting sPTB before 34 weeks (0.71 vs. 0.66, respectively). A wider UCA is associated with an increased risk of sPTB. However, while UCA alone does not have as high diagnostic performance as CL or cervical wedging alone in predicting sPTB. A reliable predictor of preterm birth is crucial for reducing foetal mortality. While a short cervix has high specificity for predicting preterm birth, its prevalence in the Thai population is only 1.1–1.75%. This has led to the search for alternative ultrasonographic parameters, such as the uterocervical angle and cervical wedging. This study evaluated the diagnostic performance of the uterocervical angle, cervical length, and cervical wedging, following up on preterm birth before 37 and 34 weeks in singleton Thai women. Furthermore, this study assessed the integration of uterocervical angle with these parameters to improve diagnostic performance. The results indicated that uterocervical angle does not have as high diagnostic performance as CL or cervical wedging alone in predicting preterm birth before 37 and 34 weeks. Meanwhile, cervical wedging and the integration of cervical parameters showed poor diagnostic performance.
DOI: 10.6084/m9.figshare.30601546.v1
title: Uterocervical angle as a predictor for spontaneous singleton preterm birth: a prospective observational study

description: The use of cervical length (CL) to predict spontaneous preterm birth (sPTB) is limited in performance due to the low prevalence of a short cervix in the Thai population. Therefore, this study aims to evaluate the diagnostic performance of the uterocervical angle (UCA) in comparison with CL, and the integration of these parameters alongside cervical wedging to predict sPTB. This prospective cohort study was designed to assess the diagnostic performance of UCA, CL, and cervical wedging for sPTB in singleton pregnancies, between gestational ages of 16 and 24 weeks, using transvaginal ultrasonography. The primary outcome was the diagnostic performance of the UCA, along with the integration of UCA with other parameters in women who delivered before 37 and 34 weeks. A total of 261 participants were included in the analysis. The optimal cut-off value for predicting sPTB before 37 weeks was 85 degrees for UCA, with a sensitivity of 44.8%, specificity of 46.6%, and a diagnostic odds ratio (DOR) of 0.71. For predicting sPTB before 34 weeks, the optimal cut-off for UCA was found to be 95 degrees, with a sensitivity of 71.4%, specificity of 59.8%, and a DOR of 3.73. The integration of UCA with CL or cervical wedging did not yield superior results compared to CL alone. The area under the receiver operating characteristic curve showed that UCA over 85 degrees was not as effective as CL under 33 mm for predicting sPTB before 37 weeks (0.54 vs. 0.51, respectively). However, CL under 30 mm was better than UCA over 95 degrees at predicting sPTB before 34 weeks (0.71 vs. 0.66, respectively). A wider UCA is associated with an increased risk of sPTB. However, while UCA alone does not have as high diagnostic performance as CL or cervical wedging alone in predicting sPTB. A reliable predictor of preterm birth is crucial for reducing foetal mortality. While a short cervix has high specificity for predicting preterm birth, its prevalence in the Thai population is only 1.1–1.75%. This has led to the search for alternative ultrasonographic parameters, such as the uterocervical angle and cervical wedging. This study evaluated the diagnostic performance of the uterocervical angle, cervical length, and cervical wedging, following up on preterm birth before 37 and 34 weeks in singleton Thai women. Furthermore, this study assessed the integration of uterocervical angle with these parameters to improve diagnostic performance. The results indicated that uterocervical angle does not have as high diagnostic performance as CL or cervical wedging alone in predicting preterm birth before 37 and 34 weeks. Meanwhile, cervical wedging and the integration of cervical parameters showed poor diagnostic performance.
DOI: 10.48597/636b-4pqx
title: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)

description: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)
DOI: 10.48597/uzn2-xq5d
title: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)

description: Measurement of HCH (hexachlorocyclohexanes) at Pallas (Matorova)
DOI: 10.6084/m9.figshare.28367569
title: Fetuin-B and oxidative stress disrupt placental trophoblasts during maternal undernourishment

description: Insufficient nutrition during pregnancy can lead to negative health outcomes for both mother and foetus. Maternal undernourishment (MUN) can be due to many factors like hyperemesis gravidarum or poor access to nutrition. Just as MUN can affect the mother and foetus, it can adversely affect the vital placental interface between the two. We suspect an observed increase in fetuin-B and oxidative stress in MUN placentas could be major players responsible for the placental insufficiency often seen with MUN. To establish a model of MUN during pregnancy, a reduced protein chow was fed to pregnant dams at a caloric deficit. We examined the MUN placentas and the downstream effects of fetuin-B and oxidative stress at the whole organ and trophoblast levels. We examined fetuin-B’s role in trophoblast pathology by measuring apoptosis, proliferation, TLR4 activation, expression of NF-ΚB p65, oxidative stress, and mitochondrial superoxide production. The effects of MUN and fetuin-B on mitochondrial superoxide production, antioxidant levels, metabolism, and electron transport chain complex activity were compared directly. Pharmaceutical interventions were utilised to narrow down specific pathways involved. Studies indicated that MUN and oxidative stress upregulated fetuin-B in the placenta. This relationship displayed a positive feedback loop as fetuin-B, in turn, promoted oxidative stress through activation of TLR4. Consequently, MUN, fetuin-B, and oxidative stress promoted apoptosis and reduced proliferative expansion of trophoblast, thereby reducing their quantity. MUN and fetuin-B reduced mitochondrial metabolism and function, promoting mitochondrial dysregulation and superoxide generation in MUN trophoblasts. Our study sheds light on the mechanisms responsible for MUN-induced placental insufficiency while identifying therapeutic agents as possible add-on interventions. Inadequate nutrition during pregnancy increases the risk of poor health outcomes and complications. This can be linked to the hindered development of the placenta, a gestational organ responsible for nutrient and waste exchange between a mother and foetus. Primary cells obtained from an established animal model were used to examine the effects of maternal undernourishment (MUN) on placental development. A commercial human cell line was also employed to investigate how fetuin-B upregulation may play a role in placental insufficiency observed during MUN. MUN was found to increase oxidative stress and fetuin-B in the placenta, which in turn reduced placental stem cell pools and promoted mitochondrial dysfunction. Our study sheds light on the mechanisms responsible for MUN-induced placental insufficiency while identifying therapeutic agents as possible add-on interventions.
DOI: 10.17026/ar/enpahz
title: PAN-00163638 - terra sigillata kom type Drag. 37 (EG)

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00163638&lt;/p&gt;
description: Modified: 2025-10-22T16:13:13+02:00