cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2f57yt
title: CCDC 2239376: Experimental Crystal Structure Determination

description: Related Article: Md. Mahbubur Rahman, Guangrong Meng, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Roman Szostak, Michal Szostak|2023|Chemical Science|14|5141|doi:10.1039/D3SC01006F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f57zv
title: CCDC 2239377: Experimental Crystal Structure Determination

description: Related Article: Md. Mahbubur Rahman, Guangrong Meng, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Roman Szostak, Michal Szostak|2023|Chemical Science|14|5141|doi:10.1039/D3SC01006F
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f5841
title: CCDC 2239382: Experimental Crystal Structure Determination

description: Related Article: Julijan Sarcevic, Tobias Heitkemper, Paul Niklas Ruth, Leonard Naß, Maximilian Kubis, Dietmar Stalke, Christian P. Sindlinger|2023|Chemical Science|14|5148|doi:10.1039/D3SC00808H
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fgs90
title: CCDC 2248532: Experimental Crystal Structure Determination

description: Related Article: Markus M. Katzenmayer, Felix Kracht, Cäcilia Maichle-Mössmer, Reiner Anwander|2023|Dalton Trans.|52|6273|doi:10.1039/D3DT00861D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fgsb1
title: CCDC 2248533: Experimental Crystal Structure Determination

description: Related Article: Markus M. Katzenmayer, Felix Kracht, Cäcilia Maichle-Mössmer, Reiner Anwander|2023|Dalton Trans.|52|6273|doi:10.1039/D3DT00861D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fgsc2
title: CCDC 2248534: Experimental Crystal Structure Determination

description: Related Article: Markus M. Katzenmayer, Felix Kracht, Cäcilia Maichle-Mössmer, Reiner Anwander|2023|Dalton Trans.|52|6273|doi:10.1039/D3DT00861D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2fgsg5
title: CCDC 2248537: Experimental Crystal Structure Determination

description: Related Article: Markus M. Katzenmayer, Felix Kracht, Cäcilia Maichle-Mössmer, Reiner Anwander|2023|Dalton Trans.|52|6273|doi:10.1039/D3DT00861D
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.21227/873c-v787
title: test agai

description: Duis sed urna nisi. Phasellus convallis aliquet cursus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Interdum et malesuada fames ac ante ipsum primis in faucibus. In sapien nisl, sodales at commodo ut, imperdiet at felis. Praesent sed suscipit lectus, in dapibus eros. Phasellus ex elit, gravida et orci sit amet, gravida fringilla turpis. In dui dolor, vehicula sit amet auctor id, volutpat vitae elit. Nulla rhoncus tortor odio, convallis fringilla risus euismod sit amet. Suspendisse enim odio, aliquam nec suscipit in, accumsan eu est. Aliquam fringilla imperdiet laoreet. Vivamus mattis varius felis sodales aliquam. Vivamus dapibus facilisis faucibus. Pellentesque pretium lectus nec nisl lacinia tempus. Morbi ac magna euismod, aliquet eros sit amet, vestibulum mauris. Vestibulum ligula sapien, blandit eu scelerisque in, sodales eget leo.
DOI: 10.7488/ds/7447
title: Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer

description: Nanostring nCounter targeted RNA Seq. data of CD4+ and CD8+ T cells isolated from human non-cancerous lung tissue and non-small cell lung cancer tumour tissue as shown in Koppensteiner et al. (in submission), "Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer". An improved mechanistic understanding of immunosuppressive pathways in NSCLC is important to develop novel diagnostic and therapeutic approaches. Here, we investigate the prognostic significance of the ectonucleotidases CD39 and CD73 in NSCLC. The expression and localisation of CD39, CD73 and CD103 was digitally quantified in a cohort of 162 early treatment naïve NSCLC patients using multiplex-immunofluorescence and related to patient outcome. Expression amongst different cell-populations was assessed via flow cytometry. Targeted RNA-Seq was performed on CD4+ and CD8+ T cells from digested NSCLC tumour tissue and single-cell RNA-Seq data was analysed to investigate the functional significance of CD39+ T cell populations. We demonstrate that flow cytometry of early untreated NSCLC patients shows an upregulation of CD39 expression in the tumour tissue amongst NK cells, fibroblasts and T cells. CD73 expression is mainly found amongst fibroblasts and Epcam+ cells in the tumour tissue. Multiplex Immunofluorescence in a cohort of 162 early untreated NSCLC patients demonstrates that CD39 expression is mainly localised in the tumour stroma while CD73 expression is equally distributed between tumour nest and stroma, and high expression of CD39 and CD73 in the tumour stroma is associated with poor RFS at 5 years. Additionally, we find that CD8+ T cells located in the tumour nest express CD103 and the density of CD39+CD103+CD8+ T cells in the tumour nest predicts improved RFS at 5 years. Targeted RNA-Seq shows that the TME of NSCLC upregulates regulatory pathways in CD4+ T cells and exhaustion in CD8+ T cells, and analysis of a single cell RNA sequencing dataset shows that CD39+CD4+ cells are enriched in Treg signature gene-sets, and CD39+CD103+ CTL show gene signatures indicative of an exhausted cytotoxic phenotype with upregulated expression of CXCL13. Knowledge of patterns of distribution and location are required to understand the prognostic impact of CD39+ T cell populations in NSCLC. This study provides an improved understanding of spatial and functional characteristics of CD39+ T cells and their significance to patient outcome.
DOI: 10.5281/zenodo.7948402
title: Italian and US news articles on COVID-19

description: Sample of Italian and US news 1/1/2020-20/10/2021obtqained searching: convalescent plasma, hydroxychloroquine, ivermectin, lockdown, mask, vaccine and vitamin D combined in a Boolean AND search with “covid AND (published OR publication OR journal)”. (In Italian,: plasma convalescenti, idrossiclorochina, ivermectina, lockdown, mascherine, vaccino, vitamina D AND “covid AND (ricerca OR pubblicato OR pubblicazione)
description: Dataset uploaded to be made available to reviewers and editors of a manuscript to be submitted (and, if accepted, to readers)
DOI: 10.5281/zenodo.7948401
title: Italian and US news articles on COVID-19

description: Sample of Italian and US news 1/1/2020-20/10/2021obtqained searching: convalescent plasma, hydroxychloroquine, ivermectin, lockdown, mask, vaccine and vitamin D combined in a Boolean AND search with “covid AND (published OR publication OR journal)”. (In Italian,: plasma convalescenti, idrossiclorochina, ivermectina, lockdown, mascherine, vaccino, vitamina D AND “covid AND (ricerca OR pubblicato OR pubblicazione)
description: Dataset uploaded to be made available to reviewers and editors of a manuscript to be submitted (and, if accepted, to readers)
DOI: 10.5519/qd.4spj6bam
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (822447 records)
DOI: 10.6084/m9.figshare.19106912
title: Locoregional lung ventilation distribution in girls with adolescent idiopathic scoliosis and healthy adolescents. The immediate effect of Schroth ‘derotational breathing’ exercise in a controlled-trial

description: Scoliosis curves present transverse plane deviations due to vertebral rotation. The Schroth method supports thoracic derotation by training patients to exert “derotational” breathing based on assumed enhanced ventilation in areas called “humps” in scoliosis and a patient’s ability to voluntarily direct ventilation in less ventilated areas called “flats.” To assess the asymmetric ventilation distribution and the ability of patients to direct their ventilation to perform derotational breathing. Twelve girls with adolescent idiopathic scoliosis and 12 healthy girls performed 3 × 3 min of rest, maximal, and derotational breathing. Electrical impedance tomography was used to record locoregional lung ventilation distribution (LLVD) within 4 thoracic regions of interest: anterior right (ROI 1), anterior left (ROI 2), posterior right (ROI 3), and posterior left (ROI 4) quadrants. Humps and flats were the sums of ROI ‘2 + 3’ and ROI ‘1 + 4,’ respectively. Overall, no difference in LLVD was observed in the flats and humps between groups. At rest, the LLVD in the humps was more elevated than that in the flats (51.5 ± 8.1% versus 43.6 ± 7.9%; p = .021) when considering both groups. Maximal and derotational breathing led to a more homogeneous LLVD between the humps and flats. The postulated derotational breathing effect was not confirmed.
DOI: 10.6084/m9.figshare.19106912.v1
title: Locoregional lung ventilation distribution in girls with adolescent idiopathic scoliosis and healthy adolescents. The immediate effect of Schroth ‘derotational breathing’ exercise in a controlled-trial

description: Scoliosis curves present transverse plane deviations due to vertebral rotation. The Schroth method supports thoracic derotation by training patients to exert “derotational” breathing based on assumed enhanced ventilation in areas called “humps” in scoliosis and a patient’s ability to voluntarily direct ventilation in less ventilated areas called “flats.” To assess the asymmetric ventilation distribution and the ability of patients to direct their ventilation to perform derotational breathing. Twelve girls with adolescent idiopathic scoliosis and 12 healthy girls performed 3 × 3 min of rest, maximal, and derotational breathing. Electrical impedance tomography was used to record locoregional lung ventilation distribution (LLVD) within 4 thoracic regions of interest: anterior right (ROI 1), anterior left (ROI 2), posterior right (ROI 3), and posterior left (ROI 4) quadrants. Humps and flats were the sums of ROI ‘2 + 3’ and ROI ‘1 + 4,’ respectively. Overall, no difference in LLVD was observed in the flats and humps between groups. At rest, the LLVD in the humps was more elevated than that in the flats (51.5 ± 8.1% versus 43.6 ± 7.9%; p = .021) when considering both groups. Maximal and derotational breathing led to a more homogeneous LLVD between the humps and flats. The postulated derotational breathing effect was not confirmed.
DOI: 10.5281/zenodo.7919249
title: Nucella lapillus

description: A dataset recording the physiological response of common dog whelk <em>Nucella lapillus</em> in response to varying environmental parameters.
DOI: 10.5281/zenodo.7919250
title: Nucella lapillus

description: A dataset recording the physiological response of common dog whelk <em>Nucella lapillus</em> in response to varying environmental parameters.
DOI: 10.5281/zenodo.7840850
title: BRCA1-specific machine learning model predicts variant pathogenicity with high accuracy - Supplementary material

description: Figure S1: Distribution of the reviewed 141 <em>BRCA1</em> missense variants; Figure S2: The Shapely values for the <em>BRCA1</em> XGBoost models; Figure S3: The Shapely values of the <em>BRCA1</em> XGBoost model used to predict the functional assays’ results for variants of uncertain significance; Table S1: The receiver operating characteristic (ROC) curve analysis for the different in silico predictions; Table S2: Cross validation of the BRCA1 model in 5 different random training and test samples; Table S3: Pathogenicity prediction and prioritization of the 31,058 unreviewed BRCA1 variants from the BRCA Exchange database.
DOI: 10.5281/zenodo.7840851
title: BRCA1-specific machine learning model predicts variant pathogenicity with high accuracy - Supplementary material

description: Figure S1: Distribution of the reviewed 141 <em>BRCA1</em> missense variants; Figure S2: The Shapely values for the <em>BRCA1</em> XGBoost models; Figure S3: The Shapely values of the <em>BRCA1</em> XGBoost model used to predict the functional assays’ results for variants of uncertain significance; Table S1: The receiver operating characteristic (ROC) curve analysis for the different in silico predictions; Table S2: Cross validation of the BRCA1 model in 5 different random training and test samples; Table S3: Pathogenicity prediction and prioritization of the 31,058 unreviewed BRCA1 variants from the BRCA Exchange database.
DOI: 10.5281/zenodo.7948436
title: BRCA1-specific machine learning model predicts variant pathogenicity with high accuracy - Supplementary material

description: Figure S1: Distribution of the reviewed 141 <em>BRCA1</em> missense variants; Figure S2: The Shapely values for the <em>BRCA1</em> XGBoost models; Figure S3: The Shapely values of the <em>BRCA1</em> XGBoost model used to predict the functional assays’ results for variants of uncertain significance; Table S1: The receiver operating characteristic (ROC) curve analysis for the different in silico predictions; Table S2: Cross validation of the BRCA1 model in 5 different random training and test samples; Table S3: Pathogenicity prediction and prioritization of the 31,058 unreviewed BRCA1 variants from the BRCA Exchange database.
DOI: 10.25403/upresearchdata.22082876
title: Children's understanding of child-wellbeing

description: This data is aimed at exploring children’s perspectives on their well-being as a pathway to a sustainable future within the South African context. A qualitative research approach was utilised which had an exploratory and descriptive purpose. The research design was an instrumental case study. The study sample was purposively selected and snowball sampling was used to recruit participants who composed of ten children between the ages of 8 and 12 residing in Region 7 of the City of Tshwane. Data collection was done through one-on-one semi-structured interviews using an interview schedule and visual communication cards. Data was analysed using Braun and Clark’s six step thematic data analysis model. Trustworthiness of data was enhanced by applying the criteria of credibility, transferability, dependably and confirmability.
DOI: 10.5281/zenodo.7948396
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- AHP method_ Module 1_Annex 4

description: This file will introduce the AHP method module 1 (Annex 4) in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.5281/zenodo.7948395
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- AHP method_ Module 1_Annex 4

description: This file will introduce the AHP method module 1 (Annex 4) in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.5281/zenodo.7948431
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- Regression Module 2 Annex 5

description: This file will introduce the Regression analysis module 2 (Annex 5) in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.5281/zenodo.7948430
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- Regression Module 2 Annex 5

description: This file will introduce the Regression analysis module 2 (Annex 5) in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.25934/pr00005199.3
title: Available IPD datapackage for study 'A Randomized, Double-blind, Comparative Study of Abiraterone Acetate Plus Low-Dose Prednisone Plus Androgen Deprivation Therapy (ADT) Versus ADT Alone in Newly Diagnosed Subjects With High-Risk, Metastatic Hormone-naive Prostate Cancer (mHNPC)'

description: The purpose of this study is to determine if newly diagnosed (within previous 3 months) participants with metastatic (spread of cancer cells from one part of the body to another ) hormone-naive prostate cancer (mHNPC) who have high-risk prognostic factors will benefit from the addition of abiraterone acetate and low-dose prednisone to androgen deprivation therapy (ADT; lutenizing hormone releasing hormone [LHRH] agonists or surgical castration).
DOI: 10.25934/pr00008722
title: Assessing the Androgen indifferent prostate cancer patients reponse to novel antiandrogen-based regimen or taxanes.

description: Androgens are hormones that are important for normal male sexual development. Androgen receptors allow the body to respond appropriately to these hormones. Testosterone is an androgen that promotes prostate cancer cell proliferation through the activation of androgen receptor. Both players are needed for cell proliferation in prostate cancer cells. For these reasons, testosterone and its receptor, namely, the Androgen Receptor (AR) have been targetted for impairing prostate cancer growth and progression. However, the recent development of novel anti-androgen therapies (ARTAs) has challenged the perception that prostate cancer proliferation and progression always depend on these two players alone. The diverse responses to these recently approved therapies with distinct mechanisms of action have exposed the biological heterogeneity/diversity of prostate cancer cells and illustrated the urgent need to apply our understanding of prostate cancer biology to clinical decision-making. 

To overcome this unmet need, some authors introduced the concept of Androgen indifferent prostate cancer (AIPC) variants to define those prostate cancer phenotypes (the set of observable characteristics or traits of an organism) that do not depend on testosterone and AR to proliferate and progress. The AIPC entity is an umbrella term that includes several clinical entities. Among these entities, the investigator will focus on the one called Aggressive Variant Prostate Cancer (AVPC). 

Since the ARTAs introduction and extensive use in prostate cancer, the androgen indifferent phenotype is becoming an increasingly common clinically meaningful entity. Among these clinical entities, the investigators will explore whether the clinical criteria for AVPC, truly identify patients not responding to novel anti-androgen therapies (ARTAs), their combinations, or androgen deprivation therapy alone. We will study AVPC as this is the most aggressive form of advanced prostate cancer, as its name suggests. The identification of the AVPC phenotype based on clinical criteria may potentially spare patients from potential side effects related to these therapies targeting androgen receptor, such as major cardiac events (MACES).

The results of our work may affect clinical trial inclusion criteria, sparing AIPC/AVPC patients from receiving AR targeting agents.
In case these clinical criteria fail to identify the refractory phenotypes, the analysis on the most informative intermediate clinical endpoint may expedite future clinical trial by shortening  the required follow-up of future studies.
DOI: 10.25934/pr00004855.2
title: Available IPD datapackage for study 'A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate (JNJ-212082) Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy'

description: The purpose of this study is to evaluate the safety and efficacy of abiraterone acetate when co-administered with prednisone in Asian patients with metastatic castration-resistant prostate cancer (mCRPC) who have failed docetaxel-based chemotherapy.
DOI: 10.34740/kaggle/dsv/5716670
title: NSE-Scripts-Data
DOI: 10.5281/zenodo.7948445
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- BN network and Bellman shortest path analysis_Module 3_Annex 6

description: This file will introduce the BN network and Bellman shortest path analysis Module 3 Annex 6 in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.5281/zenodo.7948444
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- BN network and Bellman shortest path analysis_Module 3_Annex 6

description: This file will introduce the BN network and Bellman shortest path analysis Module 3 Annex 6 in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.25747/7k9z-8m60
title: Representation of 25 records from the Portuguese National Archives in Archonto
DOI: 10.5281/zenodo.7948457
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- Anova Test Module 4 Annex 7

description: This file will introduce the ANOVA test Module 4 (Annex 7) in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.5281/zenodo.7948456
title: Deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT"- Anova Test Module 4 Annex 7

description: This file will introduce the ANOVA test Module 4 (Annex 7) in deliverable D6.2 "TOOL FOR PERFORMANCE ASSESSMENT".
DOI: 10.6084/m9.figshare.20220033
title: SciSciNet_PaperReferences

description: SciSciNet_PaperReferences
DOI: 10.6084/m9.figshare.20220033.v1
title: SciSciNet_PaperReferences

description: SciSciNet_PaperReferences
DOI: 10.6084/m9.figshare.20220039
title: SciSciNet_PaperDetails

description: SciSciNet_PaperDetails
DOI: 10.6084/m9.figshare.20220042
title: SciSciNet_Link_NobelLaureates

description: SciSciNet_Link_NobelLaureates
DOI: 10.6084/m9.figshare.20220045
title: SciSciNet_ConferenceSeries

description: SciSciNet_ConferenceSeries
DOI: 10.6084/m9.figshare.20220048
title: SciSciNet_Link_NSF

description: SciSciNet_Link_NSF
DOI: 10.6084/m9.figshare.20220048.v1
title: SciSciNet_Link_NSF

description: SciSciNet_Link_NSF
DOI: 10.6084/m9.figshare.20220051
title: SciSciNet_Link_ClinicalTrials

description: SciSciNet_Link_ClinicalTrials
DOI: 10.6084/m9.figshare.20220051.v1
title: SciSciNet_Link_ClinicalTrials

description: SciSciNet_Link_ClinicalTrials
DOI: 10.6084/m9.figshare.20220054
title: SciSciNet_Journals

description: SciSciNet_Journals
DOI: 10.6084/m9.figshare.20220057
title: SciSciNet_Affiliations

description: SciSciNet_Affiliations
DOI: 10.6084/m9.figshare.20220060
title: SciSciNet_Link_Newsfeed

description: SciSciNet_Link_Newsfeed
DOI: 10.6084/m9.figshare.20220063
title: SciSciNet_Link_NIH

description: SciSciNet_Link_NIH
DOI: 10.6084/m9.figshare.20220066
title: SciSciNet_Twitter_Metadata

description: SciSciNet_Twitter_Metadata
DOI: 10.6084/m9.figshare.20220072.v1
title: SciSciNet_Papers

description: SciSciNet_Papers