cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2012.818
title: Flow pattern of liquid multiphase flow in microreactor with different guideline structures and surface modification

description: A parallel multiphase flow in microchannel offers simple phase separation at the exit and hence, reduces the post-treatment requirements. Guideline structure and surface modification by silanization was therefore, introduced to stabilize and maintain organic-aqueous two phase parallel flow in a glass microchannel. The effects of guideline structure and surface modification on water-toluene flow pattern were investigated using computational fluid dynamics (CFD). The CFD simulation can well predict the flow patterns observed from the experiment. In straight microchannel, with the presence of guideline structure, the interface became more stable with curve shape. The role of guideline structure on the flow development was analyzed. With surface modification, the stable interface was pinned near the center of the microchannel with guideline structure. The fluids required less time to reach the stable flow pattern and could be maintained in their corresponding paths since feeding. Flow rate and flow ratio were varied to investigate the flow behaviors. The instabilities were observed at higher and lower flow rates. At higher flow rate, the interface stability could be obtained by adjusting the flow rate ratio. The parallel-slug flow pattern transition, which occurs at low flow rate, could be altered by surface modification. The effects of channel width and curve radius were demonstrated. In curved microchannel, the guideline could not stabilize the interface at the simulation flow conditions. In contrast, the surface modification could fix the interface at the channel center and maintain the parallel flow pattern at high flow rate.
DOI: 10.14457/cu.the.2012.819
title: Characterization and expression of recombinant α-glucosidase i, ii and iii in the Thai honeybee Apis cerana indica

description: α-Glucosidase (HBGase) catalyzes the non-reducing end of a substrate to liberate α-D-glucose and can be classified into three types of HBGase I, II and III according to the substrate specificity. Recombinant HBGase I, II and III from A. cerana indica (rAciHBGase I, II and III) were focused in this research in order to find a new source of enzyme. Also, this bee species is native and economic to Thailand. Previously, it was reported that the full length ORF cDNA and predicted deduced amino acid of AciHBGase III was 1,704 bp and 567 residues. In this research, the full length ORF cDNA and predicted deduced amino acid of AciHBGase I (1,734 bp and 577 residues) and AciHBGase II (1,740 bp and 579 residues) were obtained by RT-PCR. Later, the full length cDNA of AciHBGase II and III were cloned into pPICZαA expression vector and were successfully expressed in Pichia pastoris GS115. The highest expression of rAciHBGase II and III was induced by 0.5% (v/v) methanol for 96 h and 1.0% (v/v) methanol for 144 h, respectively. However, the full length cDNA of AciHBGase I was cloned into pEcoli expression vector and was successfully expressed in E. coli Rosetta (DE3) after induced by 1 mM IPTG for 3 h. The purified rAciHBGase I, II and III showed an optimum pH of 3.5, 3.5, 5.0 and was stable in the pH range of 3.5-5.0, 5.0-7.0, 5.0-7.5, respectively. In addition, rAciHBGase I and II showed a thermal optimum at 40 and 45°C, respectively. Theirs activity still remained active in an acidic environment and was acid tolerant. Also, they could work well at the relatively high temperatures (35-50 and 45-55°C, respectively). In contrast, rAciHBGase III showed an optimum activity at 37°C with no thermo tolerance. Moreover, substrate specificity of rAciHBGase I and II were sucrose but of rAciHBGase III was maltose and PNPG. In conclusion, rAciHGAases are useful and can be a new source for further application.
DOI: 10.14457/cu.the.2012.820
title: Theoretical investigation of photoinduced electron transfer in flavodoxin from molecular dynamics simulation data

description: Photoinduced electron transfer (PET) in enzyme plays significant roles in many biological processes. In this work, PET in flavodoxin from Desulfobivrio vulgaris, strain Miyazaki F (FD-DvMF) and from Helicobacter pylori (FD-HP), in which both bind one molecule of FMN as a cofactor, were studied using several molecular modeling techniques. Four FD-DvMF structures (wild type, W59F, Y97F and W59F-Y97F) were generated by homology modeling while the wild type structure of FD-HP was taken from the protein data bank. Molecular dynamics (MD) simulations of all five systems were carried out to investigate FMN-enzyme binding interaction as well as their dynamic properties. The decomposition free energy calculations indicate that the 10-loop region has the highest contribution to the binding, which is due to the H-bonding between phosphate subsite and amino acids. Ensemble of conformations obtained from the MD simulations of the five systems was supplied into the Kakitani and Mataga theory to analyze the PET mechanisms by fitting with experimental fluorescence quenching data. It was found that the mean electron transfer rate from Trp59 to excited Iso (Iso*) in the wild type was the fastest among the four FD-DvMF and it is from Tyr92 to Iso* for the FD-HP. In addition, the net electrostatic energy and the standard free energy change of the reaction are the most influential factors for the ultrafast electron transfer rate. The charge transfer (CT) was further studied by using quantum chemistry method. The calculations reveal that the state is the locally excited state while the S₂ state shows CT state characteristic.
DOI: 10.14457/cu.the.2012.821
title: Solutions of elastic medium with surface stress effects

description: This dissertation presents a theoretical study of an isotropic elastic material with the consideration of surface stress effects by adopting complete Gurtin-Murdoch continuum theory of elastic material surfaces. The fundamental solutions of an isotropic elastic layer under different loading cases, and an elastic medium with dislocations and crack are presented. Fourier and Hankel integral transforms are used to solve appropriate boundary value problems involving non-classical boundary conditions associated with the surface stresses. The analytical solutions are expressed in terms of semi-infinite integrals that can be accurately computed by employing numerical quadrature scheme. Selected numerical results are presented to portray the influence of surface stresses on the bulk elastic field. It is found that surface stresses show a significant influence on elastic fields of an isotropic elastic material especially in the vicinity of the surface. In contrast to classical elasticity, extensive parametric studies observed in numerical results indicate that the response of the bulk material becomes size-dependent with the consideration of surface stresses. Numerical results presented in this study confirm the fact that the influence of surface stresses is significant in the analysis of problems involving nanoscale systems and soft elastic materials where the surface energy effects are not negligible. The fundamental solutions presented in this study can be used in the development of boundary integral equation and other methods to analyze complicated boundary value problems associated with nanoscale structures and soft elastic solids.
DOI: 10.14457/cu.the.2012.822
title: Synthesis of bipyridyl-porphyrins as dye-photosensitizers for solar cells

description: Bipyridylporphyrin derivatives were designed and synthesized for use as dye-sensitizer in dye-sensitized solar cells (DSSCs). Bipyridylporphyrin derivatives composed of Donor-Acceptor system (D-A) based on porphyrin moiety as the electron donor (D) and bipyridyl moiety as the electron-acceptor (A). All compounds were characterized and confirmed structures by NMR, IR, Mass spectroscopy and Elemental Analysis. From the experimental and the theoretical calculation, the HOMO and LUMO energy levels of all compounds are in range, which match well with the CB band of TiO₂ favoring electron injection from the exited dyes (s*) to TiO₂ and the redox potential of the I⁻/I₃⁻ electrolyte favoring electron injection from the electrolyte to the cationic dyes (S³). Upon the studies of the photovoltaic performance measurements, a overall solar-to-electric conversion efficiency under AM 1.5 irradiation and use 0.10 M LiI, 0.05 M I₂, 0.40 M pyridine and 0.60 M TPAI as electrolytic system of 0.05, 0.28, 0.38 and 0.05 % was achieved based on the bipyridylporphyrin dyes A5, A6, A7 and A8, respectively, which were lower than the efficiency (5.97%) obtained from the standard dye N719. From the short circuit photocurrent density of the bipyridylporphyrin dyes A5, A6, A7 and A8, showed lower than the standard dye N719, possibly due to poorer electron injection from bipyridylporphyrin dyes onto the TiO₂ surface. In addition, the efficiency of the dye was improved by adding chenodeoxycholic acid (CDCA) as the coadsorbant.
DOI: 10.14457/cu.the.2012.823
title: Preparation of Ni[subscript core] – Pt alloy[subscript shell] catalysts for pem fuel cell

description: The effort to develop the PEM fuel cell electrocatalyst by lowering the precious metal loading in the composition has been extensively addressed. The carbon supported core – shell structure catalyst structure is considered to be the interesting alternative for improving the catalyst properties and stability. In the preliminary stage of this work, the preparation of Ni[subscript core] – Pt[subscript shell]/C was studied. The results suggested that the synthesis method and type of stabilizer used in the synthesis process had an effect on the metal content in the composition, particle size and the EAS of the catalyst. For the synthesis of Ni[subscript core] – PtRu[subscript shell]/C catalyst with modified polyol method, the parameters concerning in the synthesis were investigated by FCC – 2⁴ experimental design. The results indicated that the atomic ratio of platinum to ruthenium, the mole ratio of Ni precursor to the PVP stabilizer, the reduction temperature for the PtRu alloy shell formation step and the interaction between the mole ratio of Ni precursor to the PVP stabilizer and the mole ratio of Ni precursor to the PVP stabilizer affected the EAS of the synthetic catalyst. In addition, heat treatment of the Ni core particle before adding PtRu alloy shell layer could improve the activity of the Ni[subscript core] – PtRu[subscript shell]/C. The durability study of the heat – treated Ni[subscript core] – PtRu[subscript shell]/C by potential cycling technique showed the higher stability compared to the commercial Pt/C.
DOI: 10.14457/cu.the.2012.824
title: Separation of synthetic wax components by Temperature Rising Elution Fractionation (TREF)

description: TREF (Temperature Rising Elution Fractionation) was applied to study the separation of wax components. Five long chain esters were synthesized from a fatty alcohol (stearyl alcohol) and fatty acids (decanoic acid, palmitic acid, stearic acid, oleic acid and linolaic acid). Thermal property, morphology and solubility of the esters were studied in order to select the suitable esters to make the synthetic wax for this separation technique. The mixture of equal amounts of stearyl oleate, stearyl palmitate and stearyl decanoate was used as the synthetic wax in this work. A number of factors affecting the separation by TREF technique including solvent (n-hexane, isopropanol and mixed hexane and isopropanol 1:1), inert support (510 µm, 710 µm and without inert support) and temperature profile were studied.The components of the synthetic wax were successfully separated by TREF using isopropanol as the solvent, 510 µm sand as the inert support at 10 °C, 30 °C and 50 °C
DOI: 10.14457/cu.the.2012.825
title: Assessment of antenatal care utilization and client satisfaction of women in rural and urban areas of Kathmandu District of Nepal

description: Background: Antenatal care is an important determinant of high maternal mortality rate and one of the basic components of maternal health care and is also a key strategy for reducing maternal mortality. In South East Asia Region, MMR is still higher in Nepal therefore SLTHP targets to increase in the percentage of pregnant women attending a minimum of four ANC visit to 80%. This study aimed to assess the antenatal care utilization and client satisfaction in rural and urban areas of Kathmandu district of Nepal.Methods: A Cross-sectional study was carried out in two randomly selected urban (Dhapasi VDC) and rural (Jhormahankal VDC) areas of Kathmandu district of Nepal. All delivered women (urban = 188 and rural = 104) with child less than 12 months of age was interviewed with pretested questionnaire to assess the ANC utilization and client satisfaction in both areas.Results: Overall ANC utilization was 84.6% (urban 83% and rural 87.5%) and Complete ANC utilization was 58% (urban 59.6% and rural 56%) and overall satisfaction was 43.7 % (urban 44.2% and rural 42.9%). Education, occupation, food security, income, facilitation, perception, information, distance (time factor), gender, availability of medicine had significant association with ANC utilization and client satisfaction (P &lt; 0.05). Age, ethnicity, parity and family type, Social support, social barriers, household barriers had significant association with ANC utilization and place of ANC visit also had significant association with client satisfaction (P &lt; 0.05).Conclusions: The study shows that socio-demographic characteristics, social support, family support, household barriers, gender, availability of medicine are the major influencing factors for ANC utilization and client satisfaction in urban and rural areas of Kathmandu district of Nepal. Therefore, improvement of socioeconomic status, education and awareness about pregnancy are required to increase antenatal care utilization and client satisfaction. The information regarding to the association with Antenatal care Utilization and Client Satisfaction are useful for further studies especially about the different aspects of social support and barriers of ANC utilization.
DOI: 10.5281/zenodo.3406601
title: Dataset related to article "Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy"

description: This record contains raw data related to article<br> "Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy" Colorectal cancer (CRC) represents one of the major leading causes of death from cancer. Aim of the present study was to analyze outcome of oligometastatic CRC patients treated with stereotactic body radiation therapy (SBRT), and to evaluate predictive factors of survival. MATERIALS AND METHODS: We included patients with maximum 5 metastases. Previous/concomitant systemic treatments were allowed. End points of the present study were the outcome in terms of Local control of treated metastases (LC), progression free survival (PFS), and overall survival (OS). RESULTS: 437 metastases were treated in 270 patients. Lung was site of metastases in 48.5% of cases, followed by liver (36.4%). Systemic treatment was administered before SBRT in 199 patients (73.7%). Median follow-up time was 23 months (3-98.7). Rates of LC at 1, 3 and 5 years were 95%, 73% and 73%, respectively. Time from diagnosis of metastases to SBRT was the only factor predictive of LC (HR 1.62, p = 0.023). Median PFS was 8.6 months. Rates of OS at 1, 3 and 5 years were 88.5%, 56.6%, and 37.2%, respectively. Lesion greater than 30 mm (HR 1.82, p = 0.030), presence of non-lung metastases (HR 1.67, p = 0.020), the use of systemic treatment before SBRT (HR 1.82, p = 0.023), and progression of treated metastases (HR 1.80, p = 0.007), were all predictive of worse OS. CONCLUSIONS: Stereotactic body radiation therapy represents an effective approach in the management of oligometastatic CRC. Control of treated oligometastases seems to be a strong positive predictive factor for both PFS and OS.
DOI: 10.5281/zenodo.3406602
title: Dataset related to article "Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy"

description: This record contains raw data related to article<br> "Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy" Colorectal cancer (CRC) represents one of the major leading causes of death from cancer. Aim of the present study was to analyze outcome of oligometastatic CRC patients treated with stereotactic body radiation therapy (SBRT), and to evaluate predictive factors of survival. MATERIALS AND METHODS: We included patients with maximum 5 metastases. Previous/concomitant systemic treatments were allowed. End points of the present study were the outcome in terms of Local control of treated metastases (LC), progression free survival (PFS), and overall survival (OS). RESULTS: 437 metastases were treated in 270 patients. Lung was site of metastases in 48.5% of cases, followed by liver (36.4%). Systemic treatment was administered before SBRT in 199 patients (73.7%). Median follow-up time was 23 months (3-98.7). Rates of LC at 1, 3 and 5 years were 95%, 73% and 73%, respectively. Time from diagnosis of metastases to SBRT was the only factor predictive of LC (HR 1.62, p = 0.023). Median PFS was 8.6 months. Rates of OS at 1, 3 and 5 years were 88.5%, 56.6%, and 37.2%, respectively. Lesion greater than 30 mm (HR 1.82, p = 0.030), presence of non-lung metastases (HR 1.67, p = 0.020), the use of systemic treatment before SBRT (HR 1.82, p = 0.023), and progression of treated metastases (HR 1.80, p = 0.007), were all predictive of worse OS. CONCLUSIONS: Stereotactic body radiation therapy represents an effective approach in the management of oligometastatic CRC. Control of treated oligometastases seems to be a strong positive predictive factor for both PFS and OS.
DOI: 10.5281/zenodo.3407394
title: Dataset related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"

description: This record contains raw data related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis" OBJECTIVE:: To evaluate hypofractionated radiation therapy (HFRT) given at therapeutic effective doses in a phase II study. Endpoints were progression-free survival (PFS) rate, overall survival (OS), and incidence of toxicity. METHODS:: Patients with newly diagnosed glioblastoma, age ⩾70 years, Karnofsky performance scale (KPS) score ⩽60, were enrolled. The total dose of HFRT was 52.5 Gy/15 fractions, corresponded to a biological effective dose to the tumor of 70.88 Gy. RESULTS:: Thirty patients were treated, with a median age of 75 years. Concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT) was administered in 7 (23.3%) and 11 (40.7%) patients received only adjuvant TMZ-CHT. The median, 6-month PFS, and 12-month PFS were 5.0 months, 43.3%, and 20%, respectively. The median, 6-month OS, and 12-month OS were 8 months, 90%, and 30%, respectively. At the last observation time, 26 patients (86.7%) were dead and 4 (13.3%) were alive. No increase in steroid drugs was required during radiotherapy treatment and a reduction was possible in 12 (40%). Patients with KPS=60, RPA V, MGMT methylated status, neurological status stable or improved after surgery and who underwent HFRT with concurrent and adjuvant CHT, had the better outcome. CONCLUSION:: HFRT has proven to be feasible and effective, with limited morbidity, for selected elderly and frail patients with newly diagnosed glioblastoma. The primary objective of this study was not reached in the whole cohort but only in selected patients, who need more aggressive treatment.
DOI: 10.5281/zenodo.3407395
title: Dataset related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"

description: This record contains raw data related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis" OBJECTIVE:: To evaluate hypofractionated radiation therapy (HFRT) given at therapeutic effective doses in a phase II study. Endpoints were progression-free survival (PFS) rate, overall survival (OS), and incidence of toxicity. METHODS:: Patients with newly diagnosed glioblastoma, age ⩾70 years, Karnofsky performance scale (KPS) score ⩽60, were enrolled. The total dose of HFRT was 52.5 Gy/15 fractions, corresponded to a biological effective dose to the tumor of 70.88 Gy. RESULTS:: Thirty patients were treated, with a median age of 75 years. Concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT) was administered in 7 (23.3%) and 11 (40.7%) patients received only adjuvant TMZ-CHT. The median, 6-month PFS, and 12-month PFS were 5.0 months, 43.3%, and 20%, respectively. The median, 6-month OS, and 12-month OS were 8 months, 90%, and 30%, respectively. At the last observation time, 26 patients (86.7%) were dead and 4 (13.3%) were alive. No increase in steroid drugs was required during radiotherapy treatment and a reduction was possible in 12 (40%). Patients with KPS=60, RPA V, MGMT methylated status, neurological status stable or improved after surgery and who underwent HFRT with concurrent and adjuvant CHT, had the better outcome. CONCLUSION:: HFRT has proven to be feasible and effective, with limited morbidity, for selected elderly and frail patients with newly diagnosed glioblastoma. The primary objective of this study was not reached in the whole cohort but only in selected patients, who need more aggressive treatment.
DOI: 10.14457/cu.the.2012.826
title: Symbology development for hazard communication in Thailand

description: The objectives of this research were to study the visual perception of symbology on existing hazard symbols and signs in Thailand and also to identify and redevelop hazard symbols and signs for more effective visual communication during the crucial decision making time. In additional, this research aimed to study the color, shapes and text effect on visual perception of symbology on existing hazard symbols and signs in Thailand and also to investigate on the impact of visual perception on hazard symbols and signs within effected sites. This research made used of two data collection methods of qualitative methodology, which is the focus group and the quantitative methodology or the survey.This research were used to study and redevelop hazard evacuation signs for Thailand, while the survey was conducted to collect data of demographic, symbolic influence and symbology view point through quantitative and quantitative methods from 406 samples who are living or traveling to the hazardous areas. The findings indicated that the colors, the shape and the context of hazard signs and symbols impact visual perception visual development on Thai people.