cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28675790
title: Supplementary Material for: Management of Metastatic Colorectal Cancer in Pregnancy - A Systematic Review of a Multidisciplinary Challenge

description: The global incidence of early-onset colorectal cancer (EO-CRC) has increased significantly, with CRC projected to be the leading cause of cancer-related deaths among individuals aged 20-49 by 2030. Concurrently, a trend towards later age at first childbirth has been observed in industrialized countries, indicating a potential rise in CRC diagnoses during pregnancy. However, reports on managing metastatic CRC during pregnancy are limited. Bioethical concerns and the rarity of this condition contribute to the lack of clinical studies and evidence-based guidelines. This literature review, complemented by an illustrative case from our institution, aims to summarize existing knowledge and discuss optimal therapeutic approaches for this complex clinical scenario.

Methods
A comprehensive literature review was conducted using PubMed, MEDLINE, and Embase to identify studies and case reports on metastatic CRC during pregnancy, focusing on therapeutic interventions and clinical outcomes. Articles published between 1990 and 2024 were screened, excluding studies where treatment was initiated postpartum. Data on patient characteristics, treatment, and outcomes were extracted and synthesized narratively due to heterogeneity in study designs. An anonymized illustrative case was constructed through a retrospective analysis of patient records.

Results
We identified 26 cases of metastatic CRC during pregnancy in the literature. Primary symptoms at diagnosis included abdominal pain, constipation, and rectal bleeding. Most cases involved hepatic metastases, with additional pulmonary, peritoneal, or ovarian spread noted in some. Chemotherapy regimens like FOLFOX and FOLFIRI were administered in many cases during pregnancy, with varying outcomes. Some reports documented normal child development and maternal survival, while others noted adverse outcomes such as stillbirth, small-for-gestational-age infants, and maternal mortality. Surgical interventions were performed selectively, with maternal and fetal outcomes differing based on the clinical context.

Conclusion
Despite limited data on metastatic CRC treatment during pregnancy, a multidisciplinary approach that includes chemotherapy, radiotherapy, and surgical interventions, when appropriate, appears feasible. Guideline-based therapy adapted to individual clinical scenarios is crucial. Treatment in such complex cases should be managed in specialized centers equipped to address the unique challenges, ensuring optimal outcomes for both the mother and the child, even in advanced disease stages.
DOI: 10.15468/dl.gtmh8c
title: Occurrence Download

description: A dataset containing 1088 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brunei Darussalam",
 "Geometry POLYGON((114.90551 6.93211,109.74684 4.16137,108.19104 -2.13951,121.785 -7.75937,125.306 -6.29657,128.09005 -0.41366,129.28316 3.83545,114.90551 6.93211))",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "Year 2013-2013"
 ]
}

 The dataset includes 1088 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003646-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.veeywn
title: Occurrence Download

description: A dataset containing 594 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Ambrosia tomentosa Nutt."
 ]
}

 The dataset includes 594 records from 78 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003649-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15095395
title: Global Medical Education Market 2025 To 2034

description: Medical Education Market Size, Trends and Insights By Delivery Mode (Classroom-based Training, E-learning Solutions, Online Learning, Simulation-based Learning, AR/VR-based Training, AI-powered Learning), By End User Type (Medical Schools and Universities, Hospitals and Healthcare Organizations, Independent Training Institutes), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2025 – 2034.

Reports Description

Global Medical Education Market size was valued at USD 40.03 Billion in 2025 and expected to reach USD 72.35 Billion by 2034, at CAGR of 6.8% during the forecast period 2025 – 2034.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=68198
DOI: 10.5281/zenodo.15095396
title: Global Medical Education Market 2025 To 2034

description: Medical Education Market Size, Trends and Insights By Delivery Mode (Classroom-based Training, E-learning Solutions, Online Learning, Simulation-based Learning, AR/VR-based Training, AI-powered Learning), By End User Type (Medical Schools and Universities, Hospitals and Healthcare Organizations, Independent Training Institutes), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2025 – 2034.

Reports Description

Global Medical Education Market size was valued at USD 40.03 Billion in 2025 and expected to reach USD 72.35 Billion by 2034, at CAGR of 6.8% during the forecast period 2025 – 2034.

For more information, DOWNLOAD FREE SAMPLE Now at https://www.custommarketinsights.com/request-for-free-sample/?reportid=68198
DOI: 10.6084/m9.figshare.28674134
title: 原始data.zip

description: 非洲猪瘟 （ASF） 由非洲猪瘟病毒 （ASFV） 引起，是一种传染性很强的出血性疾病，对全球养猪业造成严重的社会经济影响。尽管为开发有效的控制策略做出了巨大努力，但 缺乏有效的体外模型仍然是一个关键障碍。一个关键挑战在于 ASFV 的趋向性受限;它强烈感染原代猪肺泡巨噬细胞 （PAM），并且在大多数传代细胞系中表现出较差的复制效果，阻碍了机制研究和抗病毒开发。为了解决这一限制，我们对感染早期 ASFV 感染的 PAM （原代细胞） 和 ZMAC-4 细胞 （传代巨噬细胞系） 进行了比较转录组学分析。我们的研究结果揭示了两种细胞类型之间病毒易感性和宿主反应的显着差异。转录组分析确定了关键途径的不同激活： ZMAC-4 细胞主要上调氧化应激相关途径，而 PAMs 表现出强大的细胞因子信号传导和免疫激活。通过敲低和过表达实验对差异表达基因 （DEGs） 的进一步分析表明，junctophilin-4 （JPH4） 和细胞色素 P450 1A1 （CYP1A1） 是两个潜在的宿主限制因子。本研究描述了 ASFV 允许细胞与半允许细胞中的早期宿主病毒动力学，提供了对趋向性的机制见解，并强调 JPH4/CYP1A1 是抗病毒策略的新靶点。这些发现为合理设计抗病毒策略和改进疫苗平台奠定了基础，从而解决了非洲猪瘟研究中的关键空白。
DOI: 10.15468/dl.qakcna
title: Occurrence Download

description: A dataset containing 683 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhyacotriton cascadae Good & Wake, 1992",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 683 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003650-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.29wdum
title: Occurrence Download

description: A dataset containing 1434 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Thrips palmi Karny, 1925"
 ]
}

 The dataset includes 1434 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003652-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7fbgux
title: Occurrence Download

description: A dataset containing 2850 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (Tropicos MO Specimen Data, NMNH Extant Specimen Records (USNM, US), Tropicos Specimens Non-MO, Naturalis Biodiversity Center (NL) - Botany, Royal Botanic Gardens, Kew - Herbarium Specimens, The vascular plants collection (P) at the Herbarium of the Muséum national d'Histoire Naturelle (MNHN - Paris), Digitalización y Sistematización de las Colecciones Biológicas Nacionales del Instituto de Biología, UNAM (Plantas vasculares), Field Museum of Natural History (Botany) Seed Plant Collection)",
 "TaxonKey is Genipa americana L."
 ]
}

 The dataset includes 2850 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003653-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jgeegh
title: Occurrence Download

description: A dataset containing 44 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((71.94904 52.92291,72.94111 52.95863,72.85852 53.48976,71.94153 53.51103,71.94904 52.92291))",
 "HasCoordinate is true"
 ]
}

 The dataset includes 44 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003654-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6was34
title: Occurrence Download

description: A dataset containing 703 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhyacotriton kezeri Good & Wake, 1992",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 703 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003655-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48579/pro/xyaslg
title: Extant Ethiopian Cercopithecids

description: This dataset contains dental microwear surfaces (on both crushing and shearing molar facets) of extant wild-sampled specimens of 4 species cercopithecids from Ethiopia and stored in different institutions. details are given in Read.me file. See also "Template" and "List of specimens"?
DOI: 10.15468/dl.jxt8wp
title: Occurrence Download

description: A dataset containing 87747 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Atlas of the Breeding Birds in Bulgaria"
 ]
}

 The dataset includes 87747 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003644-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gu5gfm
title: Occurrence Download

description: A dataset containing 62 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Ambrosia velutina O.E.Schulz"
 ]
}

 The dataset includes 62 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003658-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.27959616
title: Dataset from Systematic Review of Pharmacogenomic Markers Associated with Drug-Induced QT Prolongation

description: Standardised genetic variant annotation from our systematic review of pharmacogenomic markers associated with drug-induced QT prolongation.The dataset contains information on: Gene nameVariant mapped to GRCh38 (chromosome, base position, reference allele, alternative allele)HGVS or star allele: amino acid sequence or star allele (for CYP enzymes)rs ID or PharmVar code for CYP haplotypes.SPDI nomenclature MAF information (MAF allele, MAF population for reported MAF)Ancestry: of the invidual(s) where the variant was identified/reportedDrugs: associated individual drugs and drugs assigned to drug classes by 3rd level ATC code. Gene group: either (pharmaco-) kinetic or dynamic effect.Source: type of study/studies where the variant was reported
DOI: 10.6084/m9.figshare.27959616.v1
title: Dataset from Systematic Review of Pharmacogenomic Markers Associated with Drug-Induced QT Prolongation

description: Standardised genetic variant annotation from our systematic review of pharmacogenomic markers associated with drug-induced QT prolongation.The dataset contains information on: Gene nameVariant mapped to GRCh38 (chromosome, base position, reference allele, alternative allele)HGVS or star allele: amino acid sequence or star allele (for CYP enzymes)rs ID or PharmVar code for CYP haplotypes.SPDI nomenclature MAF information (MAF allele, MAF population for reported MAF)Ancestry: of the invidual(s) where the variant was identified/reportedDrugs: associated individual drugs and drugs assigned to drug classes by 3rd level ATC code. Gene group: either (pharmaco-) kinetic or dynamic effect.Source: type of study/studies where the variant was reported
DOI: 10.15468/dl.4w3fte
title: Occurrence Download

description: A dataset containing 1049 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhyacotriton olympicus (Gaige, 1917)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1049 records from 24 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003659-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.28675802
title: PLOS Digital Health Data Set

description: This dataset is related to the following paper:
DOI: 10.6084/m9.figshare.28675802.v1
title: PLOS Digital Health Data Set

description: This dataset is related to the following paper:
DOI: 10.15468/dl.d4apuy
title: Occurrence Download

description: A dataset containing 143518 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Lucanus cervus (Linnaeus, 1758))",
 "Year is not null",
 "Year is one of (2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023)",
 "HasCoordinate is TRUE",
 "DecimalLatitude is greater than or equal to 44.95782311925129",
 "DecimalLatitude is less than or equal to 58.30331634439415",
 "DecimalLongitude is greater than or equal to -10.001896207643075",
 "DecimalLongitude is less than or equal to 30.31691447027875",
 "OccurrenceStatus is Present",
 "HasGeospatialIssue is FALSE"
 ]
}

 The dataset includes 143518 records from 957 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003642-250325103851331/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15149986
title: MAKTABGACHA TA'LIMDA RAHBARLIK VA LIDERLIK FAZILATLARI
DOI: 10.5281/zenodo.15149987
title: MAKTABGACHA TA'LIMDA RAHBARLIK VA LIDERLIK FAZILATLARI
DOI: 10.15468/dl.upm3ax
title: Occurrence Download

description: A dataset containing 1637 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gobius cobitis Pallas, 1814",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Specimen, Material sample)"
 ]
 }
 },
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 10000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 1637 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004445-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7463z4
title: Occurrence Download

description: A dataset containing 341956 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Machine Observation, Human Observation, Material sample, Material citation, Specimen, Occurrence evidence)",
 "Country is Mexico",
 "TaxonKey is one of (Arachnida, Branchiopoda, Chilopoda, Copepoda, Malacostraca, Maxillopoda, Merostomata, Ostracoda, Pycnogonida, Neolepadidae, Cephalocarida, Remipedia, Tantulocarida, Hansenocarididae)",
 "Year 1925-2025"
 ]
}

 The dataset includes 341956 records from 325 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004405-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.13145/bacdive146580.20251217.10
title: Achromobacter spanius

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive146581.20241212.9.2
title: Arthrobacter sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0134697.10fu
title: SH0134697.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive146581.20251217.10
title: Arthrobacter sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive146582.20241212.9.2
title: Sphingomonas sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0134698.10fu
title: SH0134698.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive146582.20251217.10
title: Sphingomonas sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0134699.10fu
title: SH0134699.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive146583.20241212.9.2
title: Rhodococcus erythropolis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive146583.20251217.10
title: Rhodococcus erythropolis

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0134700.10fu
title: SH0134700.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive146584.20241212.9.2
title: Listeria monocytogenes

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive146584.20251217.10
title: Listeria monocytogenes

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.15156/bio/sh0134701.10fu
title: SH0134701.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.13145/bacdive146585.20241212.9.2
title: Sphingomonas sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.