cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.20846691
title: Paramedian forehead flap in the treatment of nasal, non-melanoma skin cancer: a cross-sectional study

description: ABSTRACT Introduction: nose is the central point of the face and vulnerable to the occurence of non-melanoma skin cancer (NMSC), impacting on appearance. The paramedian forehead flap (PMFF) is considered the best option to treat extensive nasal defects. The objective of this study is to present the experience on PMFF for nasal reconstruction in the treatment of NMSC of a cancer referral center. Methods: retrospective study was carried out through data from medical records of patients who underwent nasal reconstruction with PMFF due to NMSC at the Cancer Institute of the State of São Paulo (ICESP). Results: 111 patients were identified, mostly ederly, with comorbidities and on initial tumors (T1 and T2). Basal cell carcinoma (BCC) was the predominant histological type. Dorsum and tip were the most affected subunitis. In addition to skin coverage, reconstruction of the lining and structural framework was also performed in half of the cases. Second intention healing was the technique of choice in closing the donor area. Pedicle division ocurred predominantly in the second operation and the median time to complete reconstruction was 6 months. There were low complication rates. Conclusions: the PMFF is safe and effective to treat nose NMSC, even in cases of high complexity. Since the treatment time can be prolonged and impact on quality of life, it is essential to emphasize and discuss this aspect with the patients before surgery.
DOI: 10.6084/m9.figshare.20846691.v1
title: Paramedian forehead flap in the treatment of nasal, non-melanoma skin cancer: a cross-sectional study

description: ABSTRACT Introduction: nose is the central point of the face and vulnerable to the occurence of non-melanoma skin cancer (NMSC), impacting on appearance. The paramedian forehead flap (PMFF) is considered the best option to treat extensive nasal defects. The objective of this study is to present the experience on PMFF for nasal reconstruction in the treatment of NMSC of a cancer referral center. Methods: retrospective study was carried out through data from medical records of patients who underwent nasal reconstruction with PMFF due to NMSC at the Cancer Institute of the State of São Paulo (ICESP). Results: 111 patients were identified, mostly ederly, with comorbidities and on initial tumors (T1 and T2). Basal cell carcinoma (BCC) was the predominant histological type. Dorsum and tip were the most affected subunitis. In addition to skin coverage, reconstruction of the lining and structural framework was also performed in half of the cases. Second intention healing was the technique of choice in closing the donor area. Pedicle division ocurred predominantly in the second operation and the median time to complete reconstruction was 6 months. There were low complication rates. Conclusions: the PMFF is safe and effective to treat nose NMSC, even in cases of high complexity. Since the treatment time can be prolonged and impact on quality of life, it is essential to emphasize and discuss this aspect with the patients before surgery.
DOI: 10.6084/m9.figshare.20846698
title: Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery

description: Abstract The study is aimed at investigating the functional physicochemical and solid state characteristics of food-grade Tetracarpidium conophorum (T. conophorum) oil for possible application in the pharmaceutical industry for drug delivery. The oil was obtained by cold hexane extraction and its physicochemical properties including viscosity, pH, peroxide, acid, and thiobarbituric acid values, nutrient content, and fatty acid profile were determined. Admixtures of the oil with Softisan®154, a hydrogenated solid lipid from palm oil, were prepared to obtain matrices which were evaluated by differential scanning calorimetry, fourier-transform infrared spectroscopy, and x-ray diffractometry. Data from the study showed that T. conophorum oil had Newtonian flow behaviour, acidic pH, insignificant presence of hyperperoxides and malondialdehyde, contains minerals including calcium, magnesium, zinc, copper, manganese, iron, selenium, and potassium, vitamins including niacin (B3), thiamine (B1), cyanocobalamine (B12), ascorbic acid (C), and tocopherol (E), and long-chain saturated and unsaturated fatty acids including n-hexadecanoic acid, 9(Z)-octadecenoic acid, and cis-13-octadecenoic acid. The lipid matrices had low crystallinity and enthalpy values with increased amorphicity, and showed no destructive intermolecular interaction or incompatibility between T. conophorum oil and Softisan® 154. In conclusion, the results have shown that, in addition to T. conophorum oil being useful as food, it will also be an important excipient for the development of novel, safe, and effective lipid-based drug delivery systems.
DOI: 10.6084/m9.figshare.20846698.v1
title: Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery

description: Abstract The study is aimed at investigating the functional physicochemical and solid state characteristics of food-grade Tetracarpidium conophorum (T. conophorum) oil for possible application in the pharmaceutical industry for drug delivery. The oil was obtained by cold hexane extraction and its physicochemical properties including viscosity, pH, peroxide, acid, and thiobarbituric acid values, nutrient content, and fatty acid profile were determined. Admixtures of the oil with Softisan®154, a hydrogenated solid lipid from palm oil, were prepared to obtain matrices which were evaluated by differential scanning calorimetry, fourier-transform infrared spectroscopy, and x-ray diffractometry. Data from the study showed that T. conophorum oil had Newtonian flow behaviour, acidic pH, insignificant presence of hyperperoxides and malondialdehyde, contains minerals including calcium, magnesium, zinc, copper, manganese, iron, selenium, and potassium, vitamins including niacin (B3), thiamine (B1), cyanocobalamine (B12), ascorbic acid (C), and tocopherol (E), and long-chain saturated and unsaturated fatty acids including n-hexadecanoic acid, 9(Z)-octadecenoic acid, and cis-13-octadecenoic acid. The lipid matrices had low crystallinity and enthalpy values with increased amorphicity, and showed no destructive intermolecular interaction or incompatibility between T. conophorum oil and Softisan® 154. In conclusion, the results have shown that, in addition to T. conophorum oil being useful as food, it will also be an important excipient for the development of novel, safe, and effective lipid-based drug delivery systems.
DOI: 10.6084/m9.figshare.20846715
title: Water-use efficiency and onion quality in future climate scenarios

description: ABSTRACT Considering that changes in climatic parameters directly interfere in crop yields, this study aimed to evaluate the impact of changes in carbon dioxide concentrations, temperature and soil water availability on production, water-use efficiency and onion (Allium cepa L. cv. IPA 11) quality. Four levels of soil water availability (40, 60, 80 and 100 %) and two concentrations of atmospheric CO2 (770 and 390 ppm) were evaluated in three experiments with different temperature regimes (18-24-30, 22-28-34 and 26-32-38 ºC), in Phytotron growth chambers. The water-use efficiency, bulb diameter and weight, shoot dry weight, pulp frmness, soluble solids content, pH and titratable acidity were also evaluated. The increase in temperature reduces the production, and a higher soil water availability increases the production of IPA 11 onion bulbs. The temperature regime of 18-24-30 ºC and the water availability of 76.72 % provide the best water-use efficiency for the onion crop.
DOI: 10.6084/m9.figshare.20846715.v1
title: Water-use efficiency and onion quality in future climate scenarios

description: ABSTRACT Considering that changes in climatic parameters directly interfere in crop yields, this study aimed to evaluate the impact of changes in carbon dioxide concentrations, temperature and soil water availability on production, water-use efficiency and onion (Allium cepa L. cv. IPA 11) quality. Four levels of soil water availability (40, 60, 80 and 100 %) and two concentrations of atmospheric CO2 (770 and 390 ppm) were evaluated in three experiments with different temperature regimes (18-24-30, 22-28-34 and 26-32-38 ºC), in Phytotron growth chambers. The water-use efficiency, bulb diameter and weight, shoot dry weight, pulp frmness, soluble solids content, pH and titratable acidity were also evaluated. The increase in temperature reduces the production, and a higher soil water availability increases the production of IPA 11 onion bulbs. The temperature regime of 18-24-30 ºC and the water availability of 76.72 % provide the best water-use efficiency for the onion crop.
DOI: 10.6084/m9.figshare.20846719
title: Behavioral Biases and the Decision-Making in Entrepreneurs and Managers

description: ABSTRACT Objective: the present research aims to understand the role of behavioral biases present in the investment decision in entrepreneurs and managers, in the light of the behavioral finance. Theoretical approach: Considering that non-financial aspects influence the decision making of investments in real assets, the present research focuses on how individual characteristics, notably behavioral biases, can affect these investment decisions, from the perspective of Behavioral Finance. Method: a qualitative research was developed. Interviews were held with eight managers or entrepreneurs who usually make investment decisions in real assets within their organizations. Interviews were transcribed and content analysis was used to analyze the data. Results: findings suggest the presence of behavioral biases in the decision-making presented by the interviewees, specifically the optimism and overconfidence, loss aversion, self-attribution, sunk cost, endowment effect, regret, conservatism, and external agent effect. Optimism, overconfidence, and loss aversion were present in all the interviewees’ speeches. Regret and external agent effect emerged in entrepreneurs’ speech while conservatism bias emerged in the speech of managers. Conclusions: entrepreneurs and managers indistinctly presented behavioral biases; however, the triggers for those biases are diverse. When it refers to insecurity in deciding, entrepreneurs allow themselves to question their own decision-making ability, by either regret or consulting an external agent, while managers hold themselves in conservative decisions.
DOI: 10.6084/m9.figshare.20846719.v1
title: Behavioral Biases and the Decision-Making in Entrepreneurs and Managers

description: ABSTRACT Objective: the present research aims to understand the role of behavioral biases present in the investment decision in entrepreneurs and managers, in the light of the behavioral finance. Theoretical approach: Considering that non-financial aspects influence the decision making of investments in real assets, the present research focuses on how individual characteristics, notably behavioral biases, can affect these investment decisions, from the perspective of Behavioral Finance. Method: a qualitative research was developed. Interviews were held with eight managers or entrepreneurs who usually make investment decisions in real assets within their organizations. Interviews were transcribed and content analysis was used to analyze the data. Results: findings suggest the presence of behavioral biases in the decision-making presented by the interviewees, specifically the optimism and overconfidence, loss aversion, self-attribution, sunk cost, endowment effect, regret, conservatism, and external agent effect. Optimism, overconfidence, and loss aversion were present in all the interviewees’ speeches. Regret and external agent effect emerged in entrepreneurs’ speech while conservatism bias emerged in the speech of managers. Conclusions: entrepreneurs and managers indistinctly presented behavioral biases; however, the triggers for those biases are diverse. When it refers to insecurity in deciding, entrepreneurs allow themselves to question their own decision-making ability, by either regret or consulting an external agent, while managers hold themselves in conservative decisions.
DOI: 10.6084/m9.figshare.20846737
title: Patients’ medication reconciliation in a university hospital

description: Abstract Medication reconciliation is a strategy to minimize medication errors at the transition points of care. This study aimed to demonstrate the effectiveness of medication reconciliation in identifying and resolving drug discrepancies in the admission of adult patients to a university hospital. The study was carried out in a 300-bed large general public hospital, in which a reconciled list was created between drugs prescribed at admission and those used at pre-admission, adapting prescriptions from the pharmacotherapeutic guidelines of the hospital studied and the patients’ clinical conditions. One hundred seven patients were included, of which 67,3% were women, with a mean age of 56 years. Two hundred twenty-nine discrepancies were found in 92 patients; of these, 21.4% were unintentional in 31.8% of patients. The pharmacist performed 49 interventions, and 47 were accepted. Medication omission was the highest occurrence (63.2%), followed by a different dose (24.5%). Thirteen (26.5%) of the 49 unintentional discrepancies included high-alert medications according to ISMP Brazil classification. Medication reconciliation emerges as an important opportunity for the review of pharmacotherapy at transition points of care, based on the high number of unintentional discrepancies identified and resolved. During the drug reconciliation process, the interventions prevented the drugs from being misused or omitted during the patient’s hospitalization and possibly after discharge.
DOI: 10.6084/m9.figshare.20846737.v1
title: Patients’ medication reconciliation in a university hospital

description: Abstract Medication reconciliation is a strategy to minimize medication errors at the transition points of care. This study aimed to demonstrate the effectiveness of medication reconciliation in identifying and resolving drug discrepancies in the admission of adult patients to a university hospital. The study was carried out in a 300-bed large general public hospital, in which a reconciled list was created between drugs prescribed at admission and those used at pre-admission, adapting prescriptions from the pharmacotherapeutic guidelines of the hospital studied and the patients’ clinical conditions. One hundred seven patients were included, of which 67,3% were women, with a mean age of 56 years. Two hundred twenty-nine discrepancies were found in 92 patients; of these, 21.4% were unintentional in 31.8% of patients. The pharmacist performed 49 interventions, and 47 were accepted. Medication omission was the highest occurrence (63.2%), followed by a different dose (24.5%). Thirteen (26.5%) of the 49 unintentional discrepancies included high-alert medications according to ISMP Brazil classification. Medication reconciliation emerges as an important opportunity for the review of pharmacotherapy at transition points of care, based on the high number of unintentional discrepancies identified and resolved. During the drug reconciliation process, the interventions prevented the drugs from being misused or omitted during the patient’s hospitalization and possibly after discharge.
DOI: 10.6084/m9.figshare.20846746
title: The Formation of Questions by Teachers to Encourage the Participation of University Students

description: Abstract This research aimed to explore the types of questions that several teachers of English Literature, using English as a medium of instruction, asked their students, during their lessons, at a university in northern Mexico. It was a qualitative study in which the transcripts of the lessons of four teachers were analyzed. As a result, a distinction was observed between questions of a basic and complex cognitive level: the former promoted student participation and led them to rely on textual and cultural references to answer, and the latter guided the student to argue and clarify their answers. The results suggest that teachers can use basic cognitive level questions as scaffolds, if they are accompanied by some form of feedback that helps students build learning processes.
DOI: 10.6084/m9.figshare.20846746.v1
title: The Formation of Questions by Teachers to Encourage the Participation of University Students

description: Abstract This research aimed to explore the types of questions that several teachers of English Literature, using English as a medium of instruction, asked their students, during their lessons, at a university in northern Mexico. It was a qualitative study in which the transcripts of the lessons of four teachers were analyzed. As a result, a distinction was observed between questions of a basic and complex cognitive level: the former promoted student participation and led them to rely on textual and cultural references to answer, and the latter guided the student to argue and clarify their answers. The results suggest that teachers can use basic cognitive level questions as scaffolds, if they are accompanied by some form of feedback that helps students build learning processes.
DOI: 10.6084/m9.figshare.20846754
title: Dilemmas about Aging and Retirement in the Film ‘Going in Style’

description: ABSTRACT This teaching case portrays the routine of Willie, Joe, and Albert, three retired elderly people who lose their pension acquired after many years of work at the Wechsler factory. The company is ending its activities in the United States and the bank of which Joe is a client will be managing its liabilities. Living a modest life, the characters will face problems arising from the new context of the post-retirement period. To solve their problems, they decide to rob a bank. The objective of the case is to discuss the aging process and the dilemmas involving the elderly in the retirement period. As far as the data source is concerned, the case is fictitious, built from the movie Going in style, directed by Zach Braff and starring Morgan Freeman (Willie), Michael Caine (Joe), and Alan Arkin (Albert). The case uses as a didactic resource the description of scenes and subsequent preparation of teaching notes, which allows teachers and undergraduate and graduate students (both lato and stricto sensu) to analyze and critically discuss the dilemmas faced by elderly people in the retirement period. The case can be applied in disciplines such as People Management, Human Resource Management, Work and Society, Diversity in Organizations, and Labor Relations.
DOI: 10.6084/m9.figshare.20846767
title: Adaptations to the drought season and impacts on the yield of ‘Híbrido de Timor’ coffee tree in the Minas Gerais State Cerrado (Brazilian Savanna)

description: ABSTRACT Climate change threatens the survival of commercial crops due to their narrow genetic base. One of the alternatives is the identification of plants with potential for abiotic stress tolerance. This study aimed to verify the physiological and anatomical adaptations to the drought period and the impacts on the yield of ‘Híbrido de Timor’ coffee tree accessions. The experimental design was randomized blocks, in a 7 x 2 factorial arrangement, being seven genotypes (UFV 377-21, UFV 377-21, UFV 442-42, BE 5 Wush-Wush x UFV 366-08, UFV 428-02, UFV 376-31 and UFV 427-55) and two seasonal periods (dry and rainy), with two replications. The stomatal conductance; predawn water potential; levels of hydrogen peroxide and malondialdehyde; activity of the enzymes catalase, superoxide dismutase and ascorbate oxidase; ascorbate content; cuticle thickness of the adaxial surface and leaf lamina; stomatal density; ratio between polar and equatorial diameter; phloem area; area, diameter and frequency of xylem vessels; relative hydraulic conductivity; vulnerability index; and yield were evaluated. The results showed acclimatization of the accessions to the dry period, with some of them maintaining higher water potential values in the predawn; induction of the antioxidant system with the increase in the activity of the superoxide dismutase enzyme and ascorbate levels; increase in the cuticle and leaf lamina thickness; and a higher ratio between polar and equatorial diameters. Most of the evaluated accessions showed a good productive performance, especially the ‘UFV 377-21’, ‘UFV 442-42’ and ‘UFV 376-31’, with adaptations to the dry period and yield potential.
DOI: 10.6084/m9.figshare.20846767.v1
title: Adaptations to the drought season and impacts on the yield of ‘Híbrido de Timor’ coffee tree in the Minas Gerais State Cerrado (Brazilian Savanna)

description: ABSTRACT Climate change threatens the survival of commercial crops due to their narrow genetic base. One of the alternatives is the identification of plants with potential for abiotic stress tolerance. This study aimed to verify the physiological and anatomical adaptations to the drought period and the impacts on the yield of ‘Híbrido de Timor’ coffee tree accessions. The experimental design was randomized blocks, in a 7 x 2 factorial arrangement, being seven genotypes (UFV 377-21, UFV 377-21, UFV 442-42, BE 5 Wush-Wush x UFV 366-08, UFV 428-02, UFV 376-31 and UFV 427-55) and two seasonal periods (dry and rainy), with two replications. The stomatal conductance; predawn water potential; levels of hydrogen peroxide and malondialdehyde; activity of the enzymes catalase, superoxide dismutase and ascorbate oxidase; ascorbate content; cuticle thickness of the adaxial surface and leaf lamina; stomatal density; ratio between polar and equatorial diameter; phloem area; area, diameter and frequency of xylem vessels; relative hydraulic conductivity; vulnerability index; and yield were evaluated. The results showed acclimatization of the accessions to the dry period, with some of them maintaining higher water potential values in the predawn; induction of the antioxidant system with the increase in the activity of the superoxide dismutase enzyme and ascorbate levels; increase in the cuticle and leaf lamina thickness; and a higher ratio between polar and equatorial diameters. Most of the evaluated accessions showed a good productive performance, especially the ‘UFV 377-21’, ‘UFV 442-42’ and ‘UFV 376-31’, with adaptations to the dry period and yield potential.
DOI: 10.6084/m9.figshare.20846779
title: The effects of methanol extract of Galium verum L on cardiac redox state in hypertensive rats

description: Abstract The aim of this study was to assess the effects of methanol extract of G. verum on redox status of isolated heart of spontaneously hypertensive rats after ischemia. Twenty-four Wistar albino rats were divided into three groups: untreated control rats and rats that received 125 and 250 mg/kg G. verum extract for 4 weeks per os. Index of lipid peroxidation (measured as TBARS) and parameters of antioxidative defence system such as level of reduced glutathione (GSH) and activities of catalase (CAT) and superoxide dismutase (SOD) were spectrophotometrically determined in heart homogenate. The index of lipid peroxidation in heart tissue was lower in both treated groups compared to the control group. On the other hand, the activity of SOD was significantly higher after consumption of both doses, while the activity of CAT was significantly higher only after treatment with a higher dose of extract. Based on our results we might conclude that 4-week treatment with methanol extracts of G. verum has the potential to modulate myocardial redox signaling after ischemia, thus significantly alleviating cardiac oxidative stress and exerting dose-dependent antioxidant properties. Future studies are certainly necessary to fully clarify the role of this plant species in myocardial I-R injury.