cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21916008
title: Supplementary Material for: Metformin’s Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review

description: <b><i>Introduction:</i></b> Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA). LA often requires intensive-care-unit (ICU) treatment, and mortality rates are high. Here, we investigate the impact of renal dysfunction and renal replacement therapy (RRT) on the outcomes of critically ill patients with metformin-associated LA (MALA). Furthermore, we assessed associations between mortality and metformin dose, metformin plasma/serum concentrations, lactate level, and arterial pH. Finally, we investigated whether the recommended classification in MALA, metformin-unrelated LA, metformin-induced LA, and LA in metformin therapy appears useful in this regard. <b><i>Methods:</i></b> We performed a retrospective analysis based on a systematic PubMed search for publications on hyperlactatemia/LA in metformin-treated ICU patients from January 1995 to February 2020. Case-level data including demographics and clinical conditions were extracted, and logistic regression analyses were performed. <b><i>Results:</i></b> A total of 92 ICU patients were reported. Two of these patients had no comorbidities interfering with lactate metabolism. In the overall group, arterial pH, lactate levels, and metformin plasma/serum concentrations were similar in survivors versus non-survivors. Ingested daily metformin doses and plasma/serum creatinine levels were significantly higher in survivors versus non-survivors (<i>p</i> = 0.007 vs. <i>p</i> = 0.024, respectively). Higher plasma/serum creatinine levels, higher lactate levels, and lower arterial pH were all associated with patients receiving RRT (all <i>p</i> &lt; 0.05). Overall mortality was 22% (20 out of 92 patients) and did not differ between the RRT and non-RRT groups. <b><i>Conclusion:</i></b> Mortality is high in ICU patients with metformin-associated hyperlactatemia/LA. Unexpectedly, higher ingested metformin dose and plasma/serum creatinine were associated with a better outcome. Survival was similar in patients with or without need for RRT.
DOI: 10.6084/m9.figshare.21695876
title: Supplementary Material for: Up-regulated microRNA-185-3p inhibits the development of hyperlipidemia in rats

description: Introduction: MicroRNA (miR)-185-3p functions in multiple cancers, while the underlying function of miR-185-3p in hyperlipidemia remained obscure. This research was conducted to unravel its function in hyperlipidemia development via modulating mastermind-like 1 (MAML1). Methods: The hyperlipidemia rat model was established by feeding with high fat diet. MiR-185-3p and MAML1 levels in hyperlipidemia rats were detected. Adenoviral vectors altering miR-185-3p and MAML1 levels were injected into hyperlipidemia rats to examine the levels of serum lipids, oxidative stress, inflammatory cytokine, lipid accumulation and cellular morphology in liver tissues of hyperlipidemia rats. The targeting relation between miR-185-3p and MAML1 was manifested. Results: MiR-185-3p expressed at a low level while MAML1 expressed at high level in hyperlipidemia rats. MiR-185-3p overexpression or MAML1 silencing reduced levels of serum lipids, mitigated oxidative stress and inflammatory response, relieved lipid accumulation and pathological morphology in liver tissues in hyperlipidemia rats; while up-regulated MAML1 reversed the effects of augmented miR-185-3p in hyperlipidemia rats. Mechanically, miR-185-3p targeted MAML1. Conclusion: Up-regulated miR-185-3p represses hyperlipidemia development via modulating MAML1 expression. This research provides novel therapeutic candidates for the treatment of hyperlipidemia.
DOI: 10.2905/938f628a-5d2c-408a-b2b9-6e84871665b0
title: Datasets for a multidimensional analysis connecting clean energy access and social development in Sub-Saharan Africa

description: The datasets presented are used for the construction of a composite indicator, the Social Clean Energy Access (Social CEA) Index. The Social CEA Index is created in order to identify the most suitable countries for funding and implementing decentralized renewable energy systems in Sub-Saharan Africa. The Social CEA datasets include 24 indicators capturing the status of the social dimensions related to electricity access for 35 sub-Saharan Africa countries
DOI: 10.6084/m9.figshare.21916020.v1
title: Supplementary Material for: Reactive Neutrophilic Dermatoses in Adult-Onset Immunodeficiency due to Interferon-Gamma Autoantibody and Their Associated Factors

description: <b><i>Background:</i></b> Adult-onset immunodeficiency (AOID) due to interferon-gamma autoantibody is a rare, acquired immunodeficiency disease. Reactive neutrophilic dermatoses (RND), predominantly Sweet syndrome (SS), and generalized pustular eruption have been reported repeatedly. <b><i>Objectives:</i></b> The aims of this study were to describe the cutaneous manifestations in AOID patients and determine the incidence of RND and associated factors using a larger population size than have been previously reported. <b><i>Methods:</i></b> A retrospective chart review of all confirmed AOID cases in Chiang Mai University Hospital from January 2006 to June 2020 was conducted. The demographics and characteristics of RND including type, onset, and laboratory information in every episode of cutaneous manifestations were collected. Generalized estimating equations of binary logistic regression were used to determine the indicators of RND. <b><i>Results:</i></b> A total of 146 patients with confirmed AOID were identified. Of these, 57 cases (39%) developed at least one episode of RND. Thirteen cases (23%) of the patients experienced RND twice during the follow-up period. All recurrence of RND displayed the same cutaneous phenotype, with the exception of 2 cases who had both SS and generalized pustular eruption. Finally, 49 episodes of SS and 22 episodes of generalized pustular eruption were included in the analysis. All patients with RND had concomitant active opportunistic infections, of which most were non-tuberculous mycobacterium (NTM) infection. NTM infection (prevalence odds ratio [POR] 2.87), lymphadenopathy (POR 3.30) as well as lower serum alkaline phosphatase (ALP) level (POR 0.71 for every 100-unit increment in ALP) were found to be significantly associated with RND occurrence. <b><i>Conclusions:</i></b> 39% of our AOID patients experienced RND once during the course of the disease. Notable factors associated with RND occurrence were concomitant NTM infection, lymphadenopathy, and lower level of ALP.
DOI: 10.6084/m9.figshare.21896973
title: Appendix A: Analysis conditions for EPMA analyses.

description: Analytical conditions for EPMA analyses, including standards used, mapping conditions, and spectrometer setup.
DOI: 10.6084/m9.figshare.21896973.v1
title: Appendix A: Analysis conditions for EPMA analyses.

description: Analytical conditions for EPMA analyses, including standards used, mapping conditions, and spectrometer setup.
DOI: 10.6084/m9.figshare.21896577
title: Appendix B. EPMA WDS maps: data extraction

description: Locations of areas extracted from quantitative wavelength dispersive spectroscopy (WDS) maps obtained by electron microprobe analysis. Each area is an inidividual analyses of a mineral grain. Analyses are of minerals in chondrules and associated silica-rich igneous rims in CR chondrites.
DOI: 10.6084/m9.figshare.21816246
title: Appendix D. Mineral compositions in silica-rich igneous rims and chondrules from CR chondrites

description: Mineral compositions in chondrules and associated silica-rich igneous rims (SIRs) from CR chondrites. Electron microprobe data obtained by wavelength-dispersive spectroscopy (WDS) X-ray mapping.
DOI: 10.6084/m9.figshare.21816246.v1
title: Appendix D. Mineral compositions in silica-rich igneous rims and chondrules from CR chondrites

description: Mineral compositions in chondrules and associated silica-rich igneous rims (SIRs) from CR chondrites. Electron microprobe data obtained by wavelength-dispersive spectroscopy (WDS) X-ray mapping.
DOI: 10.5519/qd.yt68og86
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (252396 records)
DOI: 10.5281/zenodo.7220303
title: DR1_full

description: Attempt to make my PhD data <strong>open-access</strong> and processed interactively with a <strong>binder</strong> environment
DOI: 10.5281/zenodo.7220302
title: DR1_full

description: Attempt to make my PhD data <strong>open-access</strong> and processed interactively with a <strong>binder</strong> environment
DOI: 10.5281/zenodo.7547661
title: DR1_full

description: Attempt to make my PhD data <strong>open-access</strong> and processed interactively with a <strong>binder</strong> environment
DOI: 10.34740/kaggle/dsv/4868241
title: COVID Vaccination in World (updated daily)
DOI: 10.5281/zenodo.7499518
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7504135
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7525398
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7499517
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7527339
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7547227
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7547691
title: PIDGINv5

description: Retrained PIDGIN (https://github.com/BenderGroup/PIDGINv4) models using PIDGINv5 written in Python3 and completely refactored.
DOI: 10.5281/zenodo.7547658
title: Early Triassic Thermal Maximum and its ecological impact on conodonts

description: Supporting Information for <strong>Early Triassic Thermal Maximum and its ecological impact on conodonts</strong>
DOI: 10.5281/zenodo.7547657
title: Early Triassic Thermal Maximum and its ecological impact on conodonts

description: Supporting Information for <strong>Early Triassic Thermal Maximum and its ecological impact on conodonts</strong>
DOI: 10.6084/m9.figshare.21084829.v14
title: List of native-alien populations in South Africa.csv

description: Native-alien population is defined as a population that is within a country to which the species is native and founded by individuals moved by direct human agency (or substantial indirect human agency) over a biogeographical barrier to an area beyond the species’ native range (Nelufule et al. 2022). <br> Reference Nelufule T, Robertson MP, Wilson JRU, Faulkner KT (2022) Native-alien populations—an apparent oxymoron that requires specific conservation attention. <em>NeoBiota</em> 74: 57–74, https://doi.org/10.3897/neobiota.74.81671
DOI: 10.5281/zenodo.7520203
title: Multiplexed histology of COVID-19 post-mortem lung samples - PROLONGED CASE 2 FOV1

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (PROLONGED CASE 2 FOV1)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7520202
title: Multiplexed histology of COVID-19 post-mortem lung samples - PROLONGED CASE 2 FOV1

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (PROLONGED CASE 2 FOV1)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7525754
title: Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV2

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV2)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7525753
title: Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV2

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV2)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7524345
title: Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV1

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV1)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7525847
title: Multiplexed histology of COVID-19 post-mortem lung samples - CONROL CASE 2 FOV1

description: <strong>Image-based data set of a post-mortem lung sample from a non-COVID-19-related pneumonia donor (CONTROL CASE 2 FOV1)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7524344
title: Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV1

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV1)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7525846
title: Multiplexed histology of COVID-19 post-mortem lung samples - CONROL CASE 2 FOV1

description: <strong>Image-based data set of a post-mortem lung sample from a non-COVID-19-related pneumonia donor (CONTROL CASE 2 FOV1)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7533898
title: Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV2

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV2)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7533897
title: Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV2

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV2)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}
DOI: 10.5281/zenodo.7520241
title: Multiplexed histology of COVID-19 post-mortem lung samples - PROLONGED CASE 2 FOV2

description: <strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (PROLONGED CASE 2 FOV2)</strong> Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.
description: Funding: Deutsche Forschungsgemeinschaft HA5354/10-1, SPP1937 (HA5354/8-2) and TRR130 P17 and C01 (to Anja Hauser)
description: {"references": ["Mothes, R. and Pascual-Reguant, A. et al. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19. medRxiv 2022.03.24.22272768 (2022) doi:10.1101/2022.03.24.22272768."]}