cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/121958
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise EN551 using a Hawaii UHDAS instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618628.v1
title: Facilitators and barriers to supporting individuals with spinal cord injury in the community: experiences of family caregivers and care recipients

description: <b>Purpose</b><b>:</b> Family members make an important contribution to informal and formal care, as well as the overall health and wellbeing of individuals with spinal cord injury. Caregiving often results in negative outcomes which, if not addressed, threaten the sustainability of these critical supports. We sought to explore the perceptions of individuals with spinal cord injury and their family caregivers regarding the facilitators and barriers to undertaking and sustaining the caregiving role in the community. <b>Methods:</b> A qualitative descriptive approach with semi-structured interviews. Thematic analysis was employed to determine key themes arising from individuals with spinal cord injury (<i>n</i> = 19) and their family members’ (<i>n</i> = 16) experiences. <b>Results:</b> The following four facilitators to caregiving were identified: access to community support services, positive coping in relationship, social support, and mastery of caregiving roles. Conversely, the following six barriers to caregiving were identified: lack of access to community resources, lack of knowledge about resources and formal training, fragmented continuity of care, negative coping in relationship, role strain, and caregiver injury or illness. <b>Conclusions:</b> The current study demonstrated that positive coping, social support, skills training, access to community services and continuity of care contribute significantly to the sustainability of the spinal cord injury family caregiving role. As such, the development of future caregiver interventions should consider these facilitators.Implications for RehabilitationFamily caregivers make an important contribution to the care processes and overall quality of life of individuals with spinal cord injury post-discharge into the community.The potential negative effects of caregiving could threaten the sustainability of these critical supports.Positive coping, social support, skills training, access to community services, and continuity of care contribute significantly to the sustainability of the spinal cord injury family caregiving role.This study shows the need for better integration of family members during the rehabilitation and discharge process to better prepare them for the caregiving role. Family caregivers make an important contribution to the care processes and overall quality of life of individuals with spinal cord injury post-discharge into the community. The potential negative effects of caregiving could threaten the sustainability of these critical supports. Positive coping, social support, skills training, access to community services, and continuity of care contribute significantly to the sustainability of the spinal cord injury family caregiving role. This study shows the need for better integration of family members during the rehabilitation and discharge process to better prepare them for the caregiving role.
DOI: 10.6084/m9.figshare.7618601
title: Ocean mesoscale structure–induced air–sea interaction in a high-resolution coupled model

description: Using the Community Earth System Model framework, the authors build a very-high-resolution quasi-global coupled model by coupling an eddy-resolving quasi-global ocean model with a high-resolution atmospheric model. The model is successfully run for six years under present climate conditions, and the simulations are evaluated against observational and reanalysis data. The model is capable of simulating large-scale oceanic and atmospheric circulation patterns, sea surface temperature (SST) fronts, oceanic eddy kinetic energy, and fine-scale structures of surface winds. The ocean mesoscale structure–induced air–sea interaction characteristics are explored in detail. The model can effectively reproduce positive correlations between SST and surface wind stress induced by mesoscale structures through comparison with observations. The positive correlation is particularly significant over regions with strong oceanic fronts and eddies. However, the responses of wind stress to eddy-induced SST are weaker in the simulation than in the observations, although different magnitudes exist in different areas. Associated with weak wind responses, surface sensible heat flux responses to eddy-induced SST are underestimated slightly, while surface latent heat flux responses are overestimated because of the drier atmospheric boundary layers in the model. Both momentum mixing and pressure adjustment mechanisms play important roles in surface wind changes over oceanic fronts and eddies in the high-resolution model.
DOI: 10.7284/121957
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise EN551 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618574
title: Supplementary Material for: Age- and Sex-Related Percentiles of Skinfold Thickness, Waist and Hip Circumference, Waist-to-Hip Ratio and Waist-to-Height Ratio: Results from a Population-Based Pediatric Cohort in Germany (LIFE Child)

description: <b><i>Background:</i></b> Skinfold thickness (ST), waist circumference (WC) and hip circumference (HC) measurements are simple methods for assessing fat tissue at defined body parts. We examined these parameters in a cohort of healthy children and adolescents in Leipzig. Our study provides current percentile curves for biceps, triceps, subscapular and iliac crest ST, plus WC, HC, waist-to-hip ratio and waist-to-height ratio. <b><i>Methods:</i></b> 6,344 visits were recorded involving 2,363 individuals from 3 to 16 years in age. Continuous age- and gender-related percentiles (3rd, 10th, median, 90th, 97th percentiles) were estimated using Cole’s LMS method. <b><i>Results:</i></b> For biceps and triceps ST, boys show a peak at the beginning of adolescence with a subsequent decrease, while percentile values among girls rise across the age range. Subscapular and iliac crest percentiles also show increasing curves with disproportionately high values for P90 and P97. Boys show higher values of WC, girls have higher levels of HC. WC and HC median percentiles constantly increase in both sexes with a plateau at the age of 16 for girls. <b><i>Conclusion:</i></b> Trends for all parameters of body fat are in line with other national and international studies. Unlike the KiGGS study, our study provides circumference data across the whole of our age range, i.e. from 3 to 16 years.
DOI: 10.7284/121955
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN551 using a Furuno GP-90D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618568
title: Nitrogen addition relatively accelerate nitrogen cycle in a young subtropical Cunninghamia lanceolata (Lamb.) plantation

description: The raw data include soil inorganic N, soil N mineralization rate, DON in soil solution, leaf N and root N concentrations, δ15N enrichment factor, intrinsic water utilization efficiency, and Chemical properties of the soil<br>
DOI: 10.6084/m9.figshare.7618574.v1
title: Supplementary Material for: Age- and Sex-Related Percentiles of Skinfold Thickness, Waist and Hip Circumference, Waist-to-Hip Ratio and Waist-to-Height Ratio: Results from a Population-Based Pediatric Cohort in Germany (LIFE Child)

description: <b><i>Background:</i></b> Skinfold thickness (ST), waist circumference (WC) and hip circumference (HC) measurements are simple methods for assessing fat tissue at defined body parts. We examined these parameters in a cohort of healthy children and adolescents in Leipzig. Our study provides current percentile curves for biceps, triceps, subscapular and iliac crest ST, plus WC, HC, waist-to-hip ratio and waist-to-height ratio. <b><i>Methods:</i></b> 6,344 visits were recorded involving 2,363 individuals from 3 to 16 years in age. Continuous age- and gender-related percentiles (3rd, 10th, median, 90th, 97th percentiles) were estimated using Cole’s LMS method. <b><i>Results:</i></b> For biceps and triceps ST, boys show a peak at the beginning of adolescence with a subsequent decrease, while percentile values among girls rise across the age range. Subscapular and iliac crest percentiles also show increasing curves with disproportionately high values for P90 and P97. Boys show higher values of WC, girls have higher levels of HC. WC and HC median percentiles constantly increase in both sexes with a plateau at the age of 16 for girls. <b><i>Conclusion:</i></b> Trends for all parameters of body fat are in line with other national and international studies. Unlike the KiGGS study, our study provides circumference data across the whole of our age range, i.e. from 3 to 16 years.
DOI: 10.7284/121956
title: GNSS (Global Navigation Satellite System) data collected during research cruise EN551 using a Northstar 952 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618568.v1
title: Nitrogen addition relatively accelerate nitrogen cycle in a young subtropical Cunninghamia lanceolata (Lamb.) plantation

description: The raw data include soil inorganic N, soil N mineralization rate, DON in soil solution, leaf N and root N concentrations, δ15N enrichment factor, intrinsic water utilization efficiency, and Chemical properties of the soil<br>
DOI: 10.6084/m9.figshare.7618544
title: The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

description: Mutations in <i>C9orf72</i> leading to hexanucleotide expansions are the most common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A phenotype resembling ALS and FTD is seen in transgenic mice overexpressing the hexanucleotide expansions, but is absent in <i>C9orf72</i>-deficient mice. Thus, the exact function of C9orf72 in neurons and how loss of <i>C9orf72</i> may contribute to neuronal dysfunction remains to be clearly defined. Here, we showed that primary hippocampal neurons cultured from <i>c9orf72</i> knockout mice have reduced dendritic arborization and spine density. Quantitative proteomic analysis identified C9orf72 as a component of the macroautophagy/autophagy initiation complex composed of ULK1-RB1CC1-ATG13-ATG101. The association was mediated through the direct interaction with ATG13 via the isoform-specific carboxyl-terminal DENN and dDENN domain of C9orf72. Furthermore, <i>c9orf72</i> knockout neurons showed reduced LC3-II puncta accompanied by reduced ULK1 levels, suggesting that loss of <i>C9orf72</i> impairs basal autophagy. Conversely, wild-type neurons treated with a ULK1 kinase inhibitor showed a dose-dependent reduction of dendritic arborization and spine density. Furthermore, expression of the long isoform of human C9orf72 that interacts with the ULK1 complex, but not the short isoform, rescues autophagy and the dendritic arborization phenotypes of <i>c9orf72</i> knockout neurons. Taken together, our data suggests that <i>C9orf72</i> has a cell-autonomous role in neuronal and dendritic morphogenesis through promotion of ULK1-mediated autophagy.
DOI: 10.6084/m9.figshare.7618553
title: Supplementary Material for: The Moderating Role of Social Neighbourhood Factors in the Association between Features of the Physical Neighbourhood Environment and Weight Status

description: <b><i>Background:</i></b> This paper investigated the independent and joint associations between aspects of the physical neighbourhood environment and social neighbourhood factors with BMI and overweight status in European adults. <b><i>Methods:</i></b> Data from 5,199 participants in the SPOTLIGHT survey were analysed. Participants reported on their height, weight and perceptions of the neighbourhood. Objectively measured aspects of the physical neighbourhood environment included: presence of recreational facilities, features of the active transportation environment, neighbourhood aesthetics and presence of different types of food outlets. Social factors included the self-reported variables social network, social cohesion, social trust and perceived crime and the census variable neighbourhood socioeconomic status. Outcome measures were BMI and overweight status. Main associations between physical and social factors and BMI/overweight status were analysed using multilevel regression analyses adjusted for confounders. Moderation analysis was conducted by adding the interaction terms between physical and social neighbourhood factors one by one to the multivariable models. Significant interaction terms were then stratified. <b><i>Results:</i></b> Significant associations with BMI/overweight status were found for features of the active transportation environment and all social factors, except perceived crime. Several significant interaction terms were detected, but no significant associations between the physical neighbourhood environment and BMI/overweight status were found after stratification. <b><i>Conclusion:</i></b> We did not find consistent interactions between physical and social neighbourhood factors to explain BMI and overweight status.
DOI: 10.7284/121959
title: Gyrocompass data collected during research cruise EN551 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618544.v1
title: The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

description: Mutations in <i>C9orf72</i> leading to hexanucleotide expansions are the most common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A phenotype resembling ALS and FTD is seen in transgenic mice overexpressing the hexanucleotide expansions, but is absent in <i>C9orf72</i>-deficient mice. Thus, the exact function of C9orf72 in neurons and how loss of <i>C9orf72</i> may contribute to neuronal dysfunction remains to be clearly defined. Here, we showed that primary hippocampal neurons cultured from <i>c9orf72</i> knockout mice have reduced dendritic arborization and spine density. Quantitative proteomic analysis identified C9orf72 as a component of the macroautophagy/autophagy initiation complex composed of ULK1-RB1CC1-ATG13-ATG101. The association was mediated through the direct interaction with ATG13 via the isoform-specific carboxyl-terminal DENN and dDENN domain of C9orf72. Furthermore, <i>c9orf72</i> knockout neurons showed reduced LC3-II puncta accompanied by reduced ULK1 levels, suggesting that loss of <i>C9orf72</i> impairs basal autophagy. Conversely, wild-type neurons treated with a ULK1 kinase inhibitor showed a dose-dependent reduction of dendritic arborization and spine density. Furthermore, expression of the long isoform of human C9orf72 that interacts with the ULK1 complex, but not the short isoform, rescues autophagy and the dendritic arborization phenotypes of <i>c9orf72</i> knockout neurons. Taken together, our data suggests that <i>C9orf72</i> has a cell-autonomous role in neuronal and dendritic morphogenesis through promotion of ULK1-mediated autophagy.
DOI: 10.6084/m9.figshare.7618553.v1
title: Supplementary Material for: The Moderating Role of Social Neighbourhood Factors in the Association between Features of the Physical Neighbourhood Environment and Weight Status

description: <b><i>Background:</i></b> This paper investigated the independent and joint associations between aspects of the physical neighbourhood environment and social neighbourhood factors with BMI and overweight status in European adults. <b><i>Methods:</i></b> Data from 5,199 participants in the SPOTLIGHT survey were analysed. Participants reported on their height, weight and perceptions of the neighbourhood. Objectively measured aspects of the physical neighbourhood environment included: presence of recreational facilities, features of the active transportation environment, neighbourhood aesthetics and presence of different types of food outlets. Social factors included the self-reported variables social network, social cohesion, social trust and perceived crime and the census variable neighbourhood socioeconomic status. Outcome measures were BMI and overweight status. Main associations between physical and social factors and BMI/overweight status were analysed using multilevel regression analyses adjusted for confounders. Moderation analysis was conducted by adding the interaction terms between physical and social neighbourhood factors one by one to the multivariable models. Significant interaction terms were then stratified. <b><i>Results:</i></b> Significant associations with BMI/overweight status were found for features of the active transportation environment and all social factors, except perceived crime. Several significant interaction terms were detected, but no significant associations between the physical neighbourhood environment and BMI/overweight status were found after stratification. <b><i>Conclusion:</i></b> We did not find consistent interactions between physical and social neighbourhood factors to explain BMI and overweight status.
DOI: 10.25375/uct.7618532
title: Clinical Variables for the Adolescent Cohort Study in the Worcester region of South Africa

description: The studies described in the referenced papers collected clinical and demographic data from adolescents aged 12-18 years from high schools in the area of Worcester, South Africa. This data item contains the clinical and demographic data collected.<br><br>clinical_data.csv, clinical_data.xlsx and clinical_data.rds contain the actual clinical data. They are identical except that the first is a CSV file, the second an XLSX file and the third an RDS file. The RDS file is useful because it can be read into R using `readRDS('clinical_data.rds')` and then retains the original variable types for each of the columns. clinical_data-column_descriptions.txt describes what each of the columns are and contain. <br>
DOI: 10.6084/m9.figshare.7618541
title: Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

description: HSPB1 (heat shock protein family B [small] member 1) is a ubiquitously expressed molecular chaperone. Most mutations in <i>HSPB1</i> cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy. In this study we show that mutations in <i>HSPB1</i> lead to impairment of macroautophagic/autophagic flux. In <i>HSPB1</i> knockout cells, we demonstrate that HSPB1 is necessary for autophagosome formation, which was rescued upon re-expression of HSPB1. Employing a label-free LC-MS/MS analysis on the various HSPB1 variants (wild type and mutants), we identified autophagy-specific interactors. We reveal that the wild-type HSPB1 protein binds to the autophagy receptor SQSTM1/p62 and that the PB1 domain of SQSTM1 is essential for this interaction. Mutations in <i>HSPB1</i> lead to a decrease in the formation of SQSTM1/p62 bodies, and subsequent impairment of phagophore formation, suggesting a regulatory role for HSPB1 in autophagy via interaction with SQSTM1. Remarkably, autophagy deficits could also be confirmed in patient-derived motor neurons thereby indicating that the impairment of autophagy might be one of the pathomechanisms by which mutations in <i>HSPB1</i> lead to peripheral neuropathy. <b>Abbreviations:</b> ACD: alpha-crystallin domain; ALS: amyotrophic lateral sclerosis; ATG14: autophagy related 14; BAG1/3: BCL2 associated athanogene 1/3; CMT: Charcot-Marie-Tooth; dHMN: distal hereditary motor neuropathy; GFP: green fluorescent protein; HSPA8: heat shock protein family A (Hsp70) member 8; HSPB1/6/8: heat shock protein family B (small) member 1/6/8; LIR: LC3-interacting region; LC3B: microtubule associated protein 1 light chain 3 beta; PB1: Phox and Bem1; SQSTM1: sequestosome 1; STUB1/CHIP: STIP1 homology and U-box containing protein 1; UBA: ubiquitin-associated; WIPI1: WD repeat domain, phosphoinositide interacting 1; WT: wild-type
DOI: 10.6084/m9.figshare.7618541.v1
title: Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

description: HSPB1 (heat shock protein family B [small] member 1) is a ubiquitously expressed molecular chaperone. Most mutations in <i>HSPB1</i> cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy. In this study we show that mutations in <i>HSPB1</i> lead to impairment of macroautophagic/autophagic flux. In <i>HSPB1</i> knockout cells, we demonstrate that HSPB1 is necessary for autophagosome formation, which was rescued upon re-expression of HSPB1. Employing a label-free LC-MS/MS analysis on the various HSPB1 variants (wild type and mutants), we identified autophagy-specific interactors. We reveal that the wild-type HSPB1 protein binds to the autophagy receptor SQSTM1/p62 and that the PB1 domain of SQSTM1 is essential for this interaction. Mutations in <i>HSPB1</i> lead to a decrease in the formation of SQSTM1/p62 bodies, and subsequent impairment of phagophore formation, suggesting a regulatory role for HSPB1 in autophagy via interaction with SQSTM1. Remarkably, autophagy deficits could also be confirmed in patient-derived motor neurons thereby indicating that the impairment of autophagy might be one of the pathomechanisms by which mutations in <i>HSPB1</i> lead to peripheral neuropathy. <b>Abbreviations:</b> ACD: alpha-crystallin domain; ALS: amyotrophic lateral sclerosis; ATG14: autophagy related 14; BAG1/3: BCL2 associated athanogene 1/3; CMT: Charcot-Marie-Tooth; dHMN: distal hereditary motor neuropathy; GFP: green fluorescent protein; HSPA8: heat shock protein family A (Hsp70) member 8; HSPB1/6/8: heat shock protein family B (small) member 1/6/8; LIR: LC3-interacting region; LC3B: microtubule associated protein 1 light chain 3 beta; PB1: Phox and Bem1; SQSTM1: sequestosome 1; STUB1/CHIP: STIP1 homology and U-box containing protein 1; UBA: ubiquitin-associated; WIPI1: WD repeat domain, phosphoinositide interacting 1; WT: wild-type
DOI: 10.7284/121960
title: Gyrocompass data collected during research cruise EN551 using a Sperry MK-37 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618538.v1
title: GEUVADIS gene expression values

description: Corresponding gene expression dataset from the GEUVADIS project<br>
DOI: 10.7284/121961
title: Speedlog data collected during research cruise EN551 using a EDO MRQ-4015D instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7618538
title: Expression Data: GEUVADIS gene expression values (First 1000 entries and names adjusted)

description: Corresponding gene expression dataset from the GEUVADIS project. This dataset was not produced by me, it is just used as an example dataset in the corresponding manuscript, that can be found here:<br><br>The original dataset can be found here:https://www.ebi.ac.uk/arrayexpress/files/E-GEUV-1/<br>
DOI: 10.6084/m9.figshare.7618538.v2
title: GEUVADIS gene expression values

description: Corresponding gene expression dataset from the GEUVADIS project<br>
DOI: 10.7284/121963
title: TSG (Thermosalinograph) data collected during research cruise EN551 using a Sea-Bird SBE-21 instrument system onboard the platform RV Endeavor

description: Original (unprocessed) data collected during a Field_expedition