cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.17612412
title: Multi-omics qualification of an organ-on-a-chip model of osteolytic bone metastasis

description: This study developed a unique organ-on-a-chip model to simulate osteolytic bone metastasis and utilised a multiomics approach for characterisation/qualification and validation against in vivo data.

Using the Emulate S1 platform, we co-cultured murine osteocytes and osteoclasts to recreate the bone microenvironment and combined with breast cancer cells in a separate channel separated by a porous membrane. Using RNA sequencing, cytokine profiling, and fluorescence staining, we demonstrated the importance of the complete tri-culture model in replicating in vivo biology, and uncovered critical pathways involved in metastasis. A synergistic effect was observed in the tri-culture organ-chip model, leading to increased cancer cell migration and the upregulation of pro-metastatic and pro-inflammatory pathways that promote bone degradation and cancer progression.

This study validates an organ-chip model of osteolytic breast cancer bone metastasis as a scalable alternative to traditional animal models. Furthermore, we show how multi-omics and bioinformatics may be used for qualification and validation of organ-chip models; for unpicking the relative contribution of the different cell types; and to identify signalling pathways and therapeutic targets.





Organ-on-a-chip models of osteolytic breast cancer metastasis to bone (Bulk RNAseq of Chips 1-6)
DOI: 10.5281/zenodo.17612413
title: Multi-omics qualification of an organ-on-a-chip model of osteolytic bone metastasis

description: This study developed a unique organ-on-a-chip model to simulate osteolytic bone metastasis and utilised a multiomics approach for characterisation/qualification and validation against in vivo data.

Using the Emulate S1 platform, we co-cultured murine osteocytes and osteoclasts to recreate the bone microenvironment and combined with breast cancer cells in a separate channel separated by a porous membrane. Using RNA sequencing, cytokine profiling, and fluorescence staining, we demonstrated the importance of the complete tri-culture model in replicating in vivo biology, and uncovered critical pathways involved in metastasis. A synergistic effect was observed in the tri-culture organ-chip model, leading to increased cancer cell migration and the upregulation of pro-metastatic and pro-inflammatory pathways that promote bone degradation and cancer progression.

This study validates an organ-chip model of osteolytic breast cancer bone metastasis as a scalable alternative to traditional animal models. Furthermore, we show how multi-omics and bioinformatics may be used for qualification and validation of organ-chip models; for unpicking the relative contribution of the different cell types; and to identify signalling pathways and therapeutic targets.





Organ-on-a-chip models of osteolytic breast cancer metastasis to bone (Bulk RNAseq of Chips 1-6)
DOI: 10.15468/dl.9rtfdg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Opsariichthys bidens",
 "HasCoordinate is true",
 "Geometry POLYGON((-78 12, -73 12, -73 0, -78 0, -78 12))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035576-251025141854904/datasets/export for details.
DOI: 10.15468/dl.t4tvdy
title: Occurrence Download

description: A dataset containing 240 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-108.8688 25.34913, -108.7188 25.34913, -108.7188 25.49913, -108.8688 25.49913, -108.8688 25.34913))"
 ]
}

 The dataset includes 240 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035577-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.78zhap
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Opsariichthys uncirostris",
 "HasCoordinate is true",
 "Geometry POLYGON((-78 12, -73 12, -73 0, -78 0, -78 12))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035579-251025141854904/datasets/export for details.
DOI: 10.15468/dl.gyacqk
title: Occurrence Download

description: A dataset containing 19186 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cupressus sempervirens"
 ]
}

 The dataset includes 19186 records from 581 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035580-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qcx85j
title: Occurrence Download

description: A dataset containing 258 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-108.7188 25.34913, -108.5688 25.34913, -108.5688 25.49913, -108.7188 25.49913, -108.7188 25.34913))"
 ]
}

 The dataset includes 258 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035581-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.44927a
title: Occurrence Download

description: A dataset containing 126860 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pseudorasbora parva"
 ]
}

 The dataset includes 126860 records from 330 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035528-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zn5jwr
title: Occurrence Download

description: A dataset containing 136 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Continent is Asia",
 "Country is China",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Solidago canadensis",
 "Year 1980-2025"
 ]
}

 The dataset includes 136 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035582-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m5nuee
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Oreochromis andersonii",
 "HasCoordinate is true",
 "Geometry POLYGON((-78 12, -73 12, -73 0, -78 0, -78 12))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035583-251025141854904/datasets/export for details.
DOI: 10.15468/dl.4k3ruc
title: Occurrence Download

description: A dataset containing 1492 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON ((-111.2688 25.49913, -111.1188 25.49913, -111.1188 25.64913, -111.2688 25.64913, -111.2688 25.49913))"
 ]
}

 The dataset includes 1492 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035584-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.30627578
title: <b>Unscheduled plumage replacement in passerines: identification and implications for molt regulation</b>

description: R script and datasets to create figure 2 of manuscript
DOI: 10.6084/m9.figshare.30627578.v1
title: <b>Unscheduled plumage replacement in passerines: identification and implications for molt regulation</b>

description: R script and datasets to create figure 2 of manuscript
DOI: 10.5281/zenodo.17617640
title: Evolution of combined air pollution and heat stress extremes (CAPHSE)-attributable health and economic burdens and its inequality across global subregions

description: These uploaded datasets document the mean, maximum, and minimum estimates of near-surface temperature (T, in Kelvin), air pressure (p, in Pascal), specific humidity (SpH, unitless), and ambient PM2.5 concentration (in µgm-3) across the 21 global burden of disease (GBD)-defined global subregions for the baseline period (2005-14), and its projected estimates for mid-century (2041-50) and far-future (2071-80) under climate change scenarios.
DOI: 10.5281/zenodo.17617639
title: Evolution of combined air pollution and heat stress extremes (CAPHSE)-attributable health and economic burdens and its inequality across global subregions

description: These uploaded datasets document the mean, maximum, and minimum estimates of near-surface temperature (T, in Kelvin), air pressure (p, in Pascal), specific humidity (SpH, unitless), and ambient PM2.5 concentration (in µgm-3) across the 21 global burden of disease (GBD)-defined global subregions for the baseline period (2005-14), and its projected estimates for mid-century (2041-50) and far-future (2071-80) under climate change scenarios.
DOI: 10.15468/dl.rcwv5b
title: Occurrence Download

description: A dataset containing 121345 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Mikania"
 ]
}

 The dataset includes 121345 records from 878 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035496-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.18237677
title: Didymochlaena truncatula (Sw.) J.Sm. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:33
DOI: 10.5281/zenodo.18237678
title: Didymochlaena truncatula (Sw.) J.Sm. In: Marchesi E., Mailhos A. & Bonifacino J.M. (Eds.). Flora Uruguaya: Flora Vascular del Uruguay. ISSN 3121-2050, V. 1.0.

description: Citable snapshot. Includes PDF and CSV of collections. Date: January 13th, 2026 at 16:33
DOI: 10.15468/dl.g3ndy8
title: Occurrence Download

description: A dataset containing 184129 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is France",
 "DatasetKey is EOD – eBird Observation Dataset",
 "Geometry POLYGON((-1.71885 42.63291,0.80334 42.63291,0.80334 43.58413,-0.98514 43.87613,-1.71885 43.58413,-1.83447 43.37586,-1.71885 42.63291))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Aves",
 "Year 1980-2025"
 ]
}

 The dataset includes 184129 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028840-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yuskwf
title: Occurrence Download

description: A dataset containing 927 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Colección de la Clase Mammalia (Orden Rodentia) del Museo de Zoología de la Universidad de Concepción UCCC_MZUC_MAM"
 ]
}

 The dataset includes 927 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002505-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7ag96e
title: Occurrence Download

description: A dataset containing 277 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Amazona aestiva (Linnaeus, 1758)",
 "HasCoordinate is true",
 "Year is greater than 1989",
 "Year is less than 2026",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is Absent"
 ]
 }
 },
 "CoordinateUncertaintyInMeters is less than or equal to 1000"
 ]
}

 The dataset includes 277 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002506-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7859eq
title: Occurrence Download

description: A dataset containing 1982 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Condylura cristata (Linnaeus, 1758)",
 "Year is greater than or equal to 1950",
 {
 "or" : [
 "GadmGid is USA",
 "GadmGid is CAN",
 "GadmGid is MEX"
 ]
 }
 ]
}

 The dataset includes 1982 records from 49 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002508-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.828yqt
title: Occurrence Download

description: A dataset containing 13391 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry MULTIPOLYGON(((-79.89945 -4.17567,-79.56897 -4.17514,-79.56943 -3.91782,-79.8998 -3.91832,-79.89945 -4.17567)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Chordata"
 ]
}

 The dataset includes 13391 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002507-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wwrecv
title: Occurrence Download

description: A dataset containing 875 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Heterostemon Desf."
 ]
}

 The dataset includes 875 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002509-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.99acjn
title: Occurrence Download

description: A dataset containing 538 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Amazona oratrix Ridgway, 1887",
 "HasCoordinate is true",
 "Year is greater than 1989",
 "Year is less than 2026",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is Absent"
 ]
 }
 },
 "CoordinateUncertaintyInMeters is less than or equal to 1000"
 ]
}

 The dataset includes 538 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002510-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2mbcw7
title: CCDC 2423049: Experimental Crystal Structure Determination

description: Related Article: Claudia Rabijasz, Stefan Weber, Berthold Stöger, Karl Kirchner|2025|Organometallics|44|1006|doi:10.1021/acs.organomet.5c00095
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mcvtp
title: CCDC 2424473: Experimental Crystal Structure Determination

description: Related Article: Dominic Shiels, Adriana C. Berlfein, Barbara M. T. C. Peluzo, Lauren M. Lopez, Andrew W. Mitchell, William W. Brennessel, Matthias Zeller, Matthew R. Crawley, Suzanne C. Bart, Michael T. Ruggiero, Ellen M. Matson|2025|Inorg.Chem.|64|9180|doi:10.1021/acs.inorgchem.5c00780
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mcvvq
title: CCDC 2424474: Experimental Crystal Structure Determination

description: Related Article: Dominic Shiels, Adriana C. Berlfein, Barbara M. T. C. Peluzo, Lauren M. Lopez, Andrew W. Mitchell, William W. Brennessel, Matthias Zeller, Matthew R. Crawley, Suzanne C. Bart, Michael T. Ruggiero, Ellen M. Matson|2025|Inorg.Chem.|64|9180|doi:10.1021/acs.inorgchem.5c00780
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mcw63
title: CCDC 2424485: Experimental Crystal Structure Determination

description: Related Article: Dominic Shiels, Adriana C. Berlfein, Barbara M. T. C. Peluzo, Lauren M. Lopez, Andrew W. Mitchell, William W. Brennessel, Matthias Zeller, Matthew R. Crawley, Suzanne C. Bart, Michael T. Ruggiero, Ellen M. Matson|2025|Inorg.Chem.|64|9180|doi:10.1021/acs.inorgchem.5c00780
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mnk51
title: CCDC 2432823: Experimental Crystal Structure Determination

description: Related Article: Daniil A. Knyazev, Malini George, Daniel B. Werz|2025|Chemical Science|16|8588|doi:10.1039/D5SC00125K
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.7g9f48
title: Occurrence Download

description: A dataset containing 1754 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Sorex hoyi Baird, 1857",
 "Year is greater than or equal to 1950",
 {
 "or" : [
 "GadmGid is USA",
 "GadmGid is CAN",
 "GadmGid is MEX"
 ]
 }
 ]
}

 The dataset includes 1754 records from 48 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002511-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wct7vu
title: Occurrence Download

description: A dataset containing 28187 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Heuchera L."
 ]
}

 The dataset includes 28187 records from 345 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002512-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.77jgwm
title: Occurrence Download

description: A dataset containing 2690 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ammomanes deserti (Lichtenstein, 1823)",
 "HasCoordinate is true",
 "Year is greater than 1989",
 "Year is less than 2026",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is Absent"
 ]
 }
 },
 "CoordinateUncertaintyInMeters is less than or equal to 1000"
 ]
}

 The dataset includes 2690 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002513-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15446617
title: neoalsomitra_pilosa_zanfona_1.fasta.gz
DOI: 10.5281/zenodo.15446618
title: neoalsomitra_pilosa_zanfona_1.fasta.gz
DOI: 10.15468/dl.ukkgu9
title: Occurrence Download

description: A dataset containing 2875 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 "TaxonKey is Peromyscus polionotus (Wagner, 1843)",
 "Year is greater than or equal to 1950",
 {
 "or" : [
 "GadmGid is USA",
 "GadmGid is CAN",
 "GadmGid is MEX"
 ]
 }
 ]
}

 The dataset includes 2875 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002514-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.esrrbu
title: Occurrence Download

description: A dataset containing 6812 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Hevea Aubl."
 ]
}

 The dataset includes 6812 records from 267 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002515-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.38pkas
title: Occurrence Download

description: A dataset containing 173 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ammoperdix griseogularis (J.F.Brandt, 1843)",
 "HasCoordinate is true",
 "Year is greater than 1989",
 "Year is less than 2026",
 {
 "not" : {
 "OccurrenceStatus" : [
 "is Absent"
 ]
 }
 },
 "CoordinateUncertaintyInMeters is less than or equal to 1000"
 ]
}

 The dataset includes 173 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002516-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4u3psp
title: Occurrence Download

description: A dataset containing 2890 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Hexalobus A.DC."
 ]
}

 The dataset includes 2890 records from 107 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002519-250515123054153/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.