cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25866799.v1
title: Supplementary Material for: Experience and Learning from the COVID-19 Pandemic in Portugal: Perceptions of Community Pharmacy Professionals

description: <b><i>Background:</i></b> During the COVID-19 pandemic, community pharmacy (CP) professionals were among those who experienced the greatest risk of contracting SARS-CoV-2, which forced major adaptations. <b><i>Objectives:</i></b> The objectives of the study were to describe the changes implemented in CP professionals during the pandemic, understand the perception of professionals about their experience, and explore changes to remain. <b><i>Methods:</i></b> An observational and cross-sectional study was conducted via an online questionnaire (June–September 2020). The target population was CP professionals working in Portugal for &gt;2 years and serving the public during the pandemic. <b><i>Results:</i></b> Of a total of 353 participants, 84% were female (mean age of 37.6 years), and 81% were pharmacists (mean professional experience of 12.9 years). In the management and organizational dimensions, the most mentioned changes were adaptation to legislative changes (90%), fluctuations in the treasury (82%), and reduction of working hours (46%). Only 2% resorted to simplified layoff. In the back office, there was a need to adapt stock management (93%) and purchase personal protective equipment (99%). In the front office, there was a change in service policies – wicket or conditional opening (92%), routes of the arrival of user requests (91%), and home delivery (82%). Physical changes occurred in 100% of pharmacies. The most frequently implemented procedures were the use of protection systems and PPE, articulation with hospital pharmacies for dispensing in proximity (75%), and training in this area (55%). Regarding interpersonal climate, improvements in the connection between team members are evident: increase in mutual help (57%), solidarity (54%), and group cohesion (50%); in the relationship with clients, the majority indicated the replacement of the usual user by third parties (71%), and changes in communication channels (increase in use of technological means 68%). <b><i>Conclusions:</i></b> Results illustrate the profound impact of the pandemic on CP professionals, both professionally and personally. It also highlights the importance of their roles in proximity and community support.
DOI: 10.17632/db2d7rfprz
title: Winter Rapeseed dataset 2024

description: This study proposes a remote sensing mapping Framework for Winter Rapeseed that integrates multi-temporal Optical and synthetic aperture radar (SAR) data - WROS (Winter Rapeseed Optical SAR Integration Framework). This framework is based on an in-depth analysis of the phenological characteristics of the rapeseed growing season, constructs a dynamic time window selection mechanism, and combines a multi-dimensional feature collaboration strategy to enhance the response ability to the dynamic changes of phenology. At the same time, it improves the robustness and regional adaptability of the model in complex environments and is suitable for large-scale winter rapeseed remote sensing mapping tasks. To improve the recognition accuracy, the research innovatively designed two feature indices: The optical Winter Crop Response Difference Index based on Sentinel-2 data and the Dynamic Rapeseed Detection Index based on Sentinel-1 data The DRDI effectively highlights the differences in optical and radar temporal responses between rapeseed and non-rapeseed crops.
DOI: 10.17632/7v26dvjhps
title: Toxic effects of DEHP and MEHP on gut-liver axis in rats via intestinal flora and metabolomics

description: The dateset of toxic effects on DEHP and MEHP
DOI: 10.17632/kc4c6vcdzb
title: Maps of Modeled Storm Surge Inundation for the State of Hawaii Maui County Coastal Roads Report

description: This database consists of a series of maps showing the modeled inundation of Maui County shorelines caused by hypothetical category 1, 2, 3, and 4 storm surges. Maps show inundation along Maui County roads and CRESI transect start points on the islands of Maui and Molokai, previously identified for their vulnerability to the effects of climate change as part of the State of Hawaii Maui County Coastal Road Report (Francis et al., 2024b).
 
Transects are identified by Francis et al. (2024a). Hawaii Department of Transportation (HDOT) state routes and Maui County roads datasets are acquired from HDOT (2023) and MC (2022). Storm surge maximum of maximum (MOM) inundation extents are determined by the NOAA National Hurricane Center Storm Surge Unit using the Sea, Lake, and Overland Surges from Hurricanes (SLOSH) model and are reported in Zachry et al. (2015).

Details of the data sources and methods can be found in the "Maps of Modeled Storm Surge Inundation-README.docx"

References cited in this description can be found in the "Description References-README.docx"
DOI: 10.6084/m9.figshare.13720531.v1
title: Supplementary Material for: Asbestos-Induced Lung Cancer-Associated SNP rs13383928 Regulates <b><i>PTH2R</i></b> Expression in Lung Tissue

description: <b><i>Background:</i></b> Lung cancer is one of the most common malignant tumors, and asbestos exposure was suggested to contribute to a proportion of lung cancer cases. Previous genome-wide gene-environment interaction analysis reported that rs13383928 was associated with asbestos-related lung cancer. However, the mechanism of this association was still unclear. <b><i>Methods:</i></b> In the present study, we retrieved the genotype data from the 1,000 Genomes Project on single-nucleotide polymorphisms (SNPs) surrounding rs13383928 and analyzed the linkage disequilibrium (LD) pattern of this region. Further functional genomics analyses were performed. <b><i>Results:</i></b> The result indicated that no other SNPs were in LD with rs13383928, suggesting that rs13383928 is the causal one. The following dual luciferase assay disclosed that the T allele of rs13383928 presented significantly higher enhancer activity than G in lung cells, thus verifying that this SNP was functional in the lung. Through chromosome conformation capture, the <i>PTH2R</i> (parathyroid hormone 2 receptor)<i></i>promoter was identified to interact with the segment surrounding rs13383928. By chromatin immunoprecipitation, it was observed that the region spanning rs13383928 could bind transcription factor FOXJ2 (forkhead box J2). <b><i>Conclusion:</i></b> Our functional genomics evidence supports a link between rs13383928 and asbestos-related lung cancer through regulating <i>PTH2R</i>.
DOI: 10.6084/m9.figshare.2077918
title: Provenance shifts in an evolving Eurekan foreland basin: the Tertiary Central Basin, Spitsbergen

description: Appendix A: LA–SF–ICP–MS operating and data acquisition parameters
DOI: 10.17632/ptpfztszrn
title: Dataset of Chiral Ligands derived from Amino Acids and Peptides for Metal catalysis

description: This dataset provides a list of amino acids and peptides reported in the literature proving to be effective ligands for metal centered catalysts. Several parameters were evaluated, including amino acid combination, metal atom, carboxyl and amino protecting groups, modification of natural amino acid, and mechanism of catalysis. Along with the analysis of physical-chemical properties, the SMILES representation for each amino acid and/or peptide was generated to provide an easy-to use means of training machine learning models. This offers an opportunity for the development of improved peptide ligands for enantioselective metal-centered catalysts. Being a reliable manually curated dataset, it enables the benchmark for comparison of new termini functional groups. Moreover, the dataset provides an insight in the structures of the more successful peptide ligands and can be used as the foundation for the development of next generation of peptide-based chiral ligands.
DOI: 10.17632/2y8ntzg3pm
title: Markers of seasonal pastoral campsites: results of an osteological study of present livestock enclosures in the valley of the Karagaily-Ayat River (Chelyabinsk Region, Russia)

description: Supplementary data for the paper ''Markers of seasonal pastoral campsites: results of an osteological study of present livestock enclosures in the valley of the Karagaily-Ayat River (Chelyabinsk Region, Russia)''. The dataset contains all tabular data, a description of the Karagaily-Ayat river valley, modern livestock farming systems and a description of livestock enclosures. Images of all collected bones that were chewed by cattle and ovicaprids in the valley of the Karagaily-Ayat river are also presented. At the end, images of the most common pathologies of the skeletal system of slaughtered cattle from the studied pens are shown.
DOI: 10.17632/jcmdrm5f5x
title: Datasets of the solar quiet (Sq) and solar disturbed (SD) variations of the geomagnetic field at a midlatitudinal station in Europe obtained by different methods

description: Here we present datasets of daily variation obtained from the geomagnetic field's raw observations recorded at the Coimbra Magnetic Observatory (COI, Portugal) between 01.01.2007 and 31.12.2017, covering almost the entire solar cycle 24. Two methods were used to extract daily variability from the raw geomagnetic hourly data. The first method uses the so-called “geomagnetically quiet days” to calculate S-type variations as daily means resulting in the data sub-set named “IQD Sq and SD”. The second method uses the principal component analysis (PCA) to decompose the original series into main variability modes. The first three modes produced by PCA and explaining up to 98% or the variability of the raw data are in the data sub-set named “PCA modes”. Both methods allow to extract regular geomagnetic field variations related to daily variations (S-type variations) in the ionospheric dynamo region and some magnetospheric currents (e.g., field aligned currents). The location of COI in middle latitudes near the latitude of the ionospheric Sq current vortex's focus allows studying its seasonal and decadal variability using the S-type regular variations of the geomagnetic field measured near the ground. The S-type variations for the X and Y components of the geomagnetic field obtained at the COI observatory can also be re-scaled and used to analyze geomagnetic field variations obtained at other European geomagnetic observatories at close latitudes. The S-type variations for the Z component of the geomagnetic field obtained at the COI observatory can be compared to similar variations observed at more continental regions to study the so-called “coastal effect” in the geomagnetic field variations. Institution: University of Coimbra, Geophysical and Astronomical Observatory, Coimbra Magnetic Observatory City: Coimbra Country: Portugal Latitude and longitude for collected data: 40º 13’ N, 8º 25.3’ W, 99 m a.s.l. Primary data sources: The raw geomagnetic field data can be downloaded from the World Data Centre for Geomagnetism, Geomagnetism Data Portal (http://www.wdc.bgs.ac.uk/dataportal/), station name: “Coimbra”, IAGA code: “COI”
DOI: 10.17632/vs2pgh8sb4
title: Data for: Characterization of three new viruses of the family Betaflexiviridae associated with camellia ringspot disease
DOI: 10.17632/xfjhkppykr
title: Scheduled Castes Federation of Pakistan:Basic Manifesto, Constitution and Program

description: شیڈیول_کاسٹ_فیڈریشن_آف_پاکستان Scheduled Castes Federation of Pakistan بنیادی منشور، دستور و پروگرام Basic Manifesto, and Constitution Program (Proposed Manifesto) ( مجوزہ_دستور) گنپت_راۓ Ganpat Rai پبلشر : شعبہ نشر و اشاعت، شیڈیول کاسٹ فیڈریشن آف پاکستان
DOI: 10.6084/m9.figshare.25155653.v1
title: Supplementary Tables -BioAge

description: Supplementary Tables from <b>Aging human abdominal subcutaneous white adipose tissue at single cell resolution.</b><br><b>Abstract</b>White adipose tissue (WAT) is a robust energy storage and endocrine organ critical for maintaining metabolic health as we age. Our aim was to identify cell-specific transcriptional aberrations that occur in WAT with aging. We leveraged full-length snRNA-Seq and histology to characterize the cellular landscape of human abdominal subcutaneous WAT in a prospective cohort of 10 younger (≤30 years) and 10 older individuals (≥65 years) balanced for sex and body mass index (BMI). The older group had greater cholesterol, very-low-density lipoprotein, triglycerides, thyroid stimulating hormone, and aspartate transaminase compared to the younger group (p&lt; 0.05). We highlight that aging WAT is associated with adipocyte hypertrophy, increased proportions of lipid-associated macrophages and mast cells, an upregulation of immune responses linked to fibrosis in pre-adipocyte, adipocyte, and vascular populations, and highlight CXCL14 as a biomarker of these processes. We show that older WAT has elevated levels of senescence marker p16 in adipocytes and identify the adipocyte subpopulation driving this senescence profile. We confirm that these transcriptional and phenotypical changes occur without overt fibrosis and in older individuals that have comparable WAT insulin sensitivity to the younger individuals.
DOI: 10.6084/m9.figshare.8019401.v1
title: Stage I-III colon cancer patients with tumor deposits.xlsx

description: Data set of patients with stage I-III colon cancer.<br>
DOI: 10.17632/58ktd2vxvf
title: Convergent Aedes and Drosophila CidB interactomes suggest cytoplasmic incompatibility targets are conserved.

description: Excel Sheet Description
i. Sheet a describes the constructs used for the pull-down bioassays

ii. Sheet b is the supplementary file for Table 1. It shows the compiled Aedes proteins enriched in CidB* interactome data from scaffold data. Data were first ranked by biological replicates of enrichment. Then, ranked by average Frequency score (F-score). 74 total proteins with at least 2 biological replicates. 58 proteins were enriched (i.e., with an average value of F &gt;= 1). Red boxes indicate where a technical replicate was inconsistent i.e., with zero peptides in one technical replicate but &gt;= 1 in another. We did not consider these hits reliable and marked them as inconsistencies. 

iii. Sheet c is the compiled triplicate of data in sheet b

iv. Sheet d is the supplementary file for Table 2. It shows the compiled Aedes proteins enriched in CidB* + CidA interactome data. Data were first ranked by biological replicates of enrichment. Then, ranked by average Frequency score (F-score). 48 proteins with at least 3 biological replicates. Only 28 enriched proteins (i.e., with an average F value &gt;= 1). Yellow boxes indicate where a peptide was not enriched (n=15) i.e., average F score &lt; 1. 

v. Sheet e is the compiled triplicate of data in sheet d

vi. Sheet f is the protein overlap in Aedes CidB* vs Aedes + CidB* + CidA

*Comprehensive data description can be found in the Data Description Word File
DOI: 10.6084/m9.figshare.22638382.v1
title: ARRIVE author checklist

description: ARRIVE guidelines checklist (author)
DOI: 10.17632/3dtxzyj9h6
title: Becker’s naevi are associated with neurological abnormalities - supplementary table

description: Phenotypic, histological and genotypic characterisation of the patient cohort. No patient had sufficient café-au lait macules to suggest a diagnosis of any germline condition such as neurofibromatosis, and no patient fulfilled the diagnostic criteria for either germline or mosaic neurofibromatosis. BN: Becker’s naevus SMH: Smooth Muscle Hamartoma
DOI: 10.17632/8vbnmnkcgt
title: Maturarbeit von Laurent Emmenegger Videos

description: Hier können sie die Videos finden, welche ich im Verlauf meiner Arbeit erhalten habe und die ich benutzt habe um meine Schlüsse zu erstellen. Es ist Jeweils das Video der Wildkamera und das Bild das die Kamerafalle erstellt hat nach Ereignis sortiert.
DOI: 10.17632/k87237wjk8
title: Data for: Engineering Human Ventricular Heart Tissues Based on Macroporous Iron Oxide Scaffolds

description: flow cytometry raw data for fig 2c
DOI: 10.17632/n5nst8f4fh
title: Conocimiento, creencias y aceptabilidad de la vacuna contra el Virus del Papiloma Humano en padres de Chihuahua, México 

description: Base de datos incluye datos socidemográficos, preguntas relacionadas con el  conocimiento, creencias y aceptabilidad de la vacuna contra el Virus del Papiloma Humano en padres
DOI: 10.6084/m9.figshare.26493724.v1
title: EVM_sequence_cds.fa

description: The freshwater aquaculture species <i>Cirrhinus mrigala</i>, commonly known as mrigal, holds significance in the carp-dominated aquaculture system globally. Despite constituting only 1.08% of the total freshwater aquaculture production, mrigal is the third most important Indian major carp. Thus, this study aims to address this gap by generation high quality genome assembly using PacBio long reads, Illumina short reads, and Hi-C scaffolding. The characterization of assembled highly contiguous genome, 1.057 Gb in size, includes repeats characterization and gene prediction, revealed 22,181 unique genes with functional annotations. The orthology analysis based on genes with single copy places <i>C. mrigala</i> in a distinct position within the Otophysi clade. Additionally, the study delves into Hox gene clusters, identifying 38 Hox genes distributed in seven clusters. The present genomic information offers potential applications for sustainable aquaculture management, including selection programs for economic traits.
DOI: 10.6084/m9.figshare.28620911.v1
title: 2022.1-2023.12 contrallateral group database(personal info hidden)

description: Background: Hip fractures are common in elderly patients, with some experiencing contralateral fractures. Even so, information on predictors of hip fractures in elderly adults is lacking. In this study, we investigated risk factors for contralateral hip fractures after surgical treatment of primary fractures. Methods: This was a prospective cohort study of 115 patients aged ≥65 years with low-energy hip fractures. The clinical parameters evaluated included age, sex, bone mineral density (BMD), T score, and hip flexor strength deficit. Patients were stratified into two groups: those with (n=12) and those without contralateral fractures (n=103). Results: Contralateral fractures occurred in 10.4% of the patients. Logistic regression revealed that age (OR=1.08), reduced BMD (OR=0.33), lower T score (OR=1.45), and hip flexor imbalance (OR=2.2) were significant predictors. Conclusion: A multimodal approach that integrates anti-osteoporosis therapy and targeted rehabilitation may reduce contralateral fracture risk in elderly patients.
DOI: 10.6084/m9.figshare.11435850.v1
title: 6-days breakfast skipping_data

description: core body temperature, expression of clock genes, heart rate variability, and melatonin
DOI: 10.6084/m9.figshare.13065326.v1
title: Supplementary Material for: Relationship between Aflibercept Efficacy and Genetic Variants of Genes Associated with Neovascular Age-Related Macular Degeneration: The BIOIMAGE Trial

description: <b><i>Purpose:</i></b> To identify the genetic variants of the vascular endothelial growth factor (VEGF) pathway genes and other genes associated with neovascular age-related macular degeneration (nAMD) as possible predictive biomarkers of a favorable treatment response to aflibercept. <b><i>Design:</i></b> A 52-week (with extension phase: 104-week), prospective, open-label, single-arm, multicenter, phase IV trial was conducted in Spain. <b><i>Participants:</i></b> Patients with nAMD were enrolled. <b><i>Methods:</i></b> Aflibercept was administered every 8 weeks until week 48 (after 1-monthly loading doses over 3 months). After week 48, the interval between visits for aflibercept administration was extended by 2 weeks per visit to a maximum of 12 weeks if no evidence of disease activity was observed. A total of 338 SNPs in 90 genes associated with nAMD were analyzed. <b><i>Main Outcome Measures:</i></b> Efficacy was evaluated mainly with best-corrected visual acuity (BCVA), and adverse events (AEs) were reported. Treatment efficacy was defined as an increase in BCVA ≥15 letters versus the baseline visit. Univariate and multivariate logistic regressions were used to associate single-nucleotide polymorphisms (SNPs) and treatment efficacy. <b><i>Results:</i></b> 194 nonconsecutive patients were enrolled, 170 completed the 52-week follow-up, and of the 85 patients who started the extension phase, 77 completed this phase. Mean BCVA increased from baseline to weeks 52 and 104 by 9 and 10 letters (<i>p</i> = 0.0001 for both), respectively. The percentages of patients gaining ≥15 letters in weeks 52 and 104 were 33 and 31%, respectively. Multivariate logistic regression showed significant associations of 6 SNPs (in 6 genes) with treatment efficacy: rs12366035 (<i>VEGFB</i>; TT; odds ratio [OR] 217), rs25681 (<i>C5</i>; AA/AG; OR 19.7/8.3), rs17793056 (<i>CX3CR1</i>; CT/CC; OR 8.1/6.2), rs1800775 (<i>CETP</i>; CC; OR 6.6), rs2069845 (<i>IL6</i>; GG/AA; OR 5.6/3.3), and rs13900 (<i>CCL2</i>; CT; OR 4.0). One percent of the patients reported arteriothrombolic events related to aflibercept (cerebrovascular accident) according to the Antiplatelet Trialist Collaboration, and 2% reported serious ocular (retinal pigment epithelial tear, retinal tear, and endophthalmitis) and systemic (cardiac failure, hypersensitivity, and transient ischemic attack) AEs related to aflibercept. <b><i>Conclusions:</i></b> Results suggest strong pharmacogenetic associations between one genetic variant of <i>VEGFB</i> (TT, rs12366035) and<i> C5</i> (AA, rs12366035) genes and the BCVA response after 52-week aflibercept treatment in patients with nAMD. Likewise, the results support the efficacy of aflibercept observed in phase III studies and a good safety profile.
DOI: 10.6084/m9.figshare.19739023.v5
title: DATA KEVIN SURVEY 3 AUGUST 2021

description: <br> This data is derived from a cross-sectional survey used to collect primary data from 211 randomly selected cage operators (98) and pond farmers (113) in Kenya's Siaya, Kisumu, and Homabay Counties between December 2020 and April 2021. It includes variables relating to the relationship between TAM constructs, namely Perceived Ease of Use (PEOU), Perceived Usefulness (PU), Attitude towards Use (ATT), and Behavioral Intention (BI) to use Black Soldier Fly Larvae in Aquaculture.
DOI: 10.6084/m9.figshare.22270141.v1
title: Supplementary Material for: Genomic Investigation of Remission and Relapse of Psychotic Depression Treated with Sertraline Plus Olanzapine: the STOP-PD II Study

description: Introduction: Little is known regarding genetic factors associated with treatment outcome of psychotic depression. We explored genomic associations of remission and relapse of psychotic depression treated with pharmacotherapy. Methods: Genomic analyses were performed in 171 men and women aged 18-85 years with an episode of psychotic depression who participated in the Study of the Pharmacotherapy of Psychotic Depression II (STOP-PD II). Participants were treated with open-label sertraline plus olanzapine for up to 12 weeks; those who achieved remission or near-remission and maintained it following 8 weeks of stabilization were eligible to participate in a 36-week randomized controlled trial that compared sertraline plus olanzapine with sertraline plus placebo in preventing relapse. Results: There were no genome-wide significant associations with either remission or relapse. However, at a suggestive threshold, SNP rs1026501 (31kb from SYNPO2) in the whole sample and rs6844137 (within the intronic region of SYNPO2) in the European-ancestry subsample were associated with a decreased likelihood of remission. In polygenic risk analyses, participants who had greater improvement after antidepressant treatment showed a higher likelihood of reaching remission. Those who achieved remission and had a higher polygenic risk for Alzheimer’s disease had a significantly decreased likelihood of relapse. Conclusion: Our analyses provide preliminary insights into the genetic architecture of remission and relapse in a well-characterized group of patients with psychotic depression.