cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7510787.v1
title: Clinical impact of thyroglobulin (Tg) and Tg autoantibody (TgAb) measurements in needle washouts of neck lymph node biopsies in the management of patients with papillary thyroid carcinoma

description: ABSTRACT Objectives The presence of thyroglobulin (Tg) in needle washouts of fine needle aspiration biopsy (Tg-FNAB) in neck lymph nodes (LNs) suspected of metastasis has become a cornerstone in the follow-up of patients with papillary thyroid carcinoma (PTC). However, there are limited data regarding the measurement of anti-Tg antibodies in these washouts (TgAb-FNAB), and it is not clear whether these antibodies interfere with the assessment of Tg-FNAB or whether there are other factors that would more consistently justify the finding of low Tg-FNAB in metastatic LNs. Materials and methods We investigated 232 FNAB samples obtained from suspicious neck LNs of 144 PTC patients. These samples were divided according to the patient’s serum TgAb status: sTgAb- (n = 203 samples) and sTgAb+ (n = 29). The TgAb-FNAB levels were measured using two different assays. Tg-FNAB was also measured using two assays when low levels (&lt; 10 ng/mL) were identified in the first assay of the metastatic LNs from the sTgAb+ samples. Results The TgAb-FNAB results were negative in both assays in all samples. Low levels of Tg-FNAB were identified in 11/16 of the metastatic LNs of the sTgAb+ patients and 16/63 of the sTgAb- patients (p &lt; 0.05) using assay 1. The measurement of the Tg-FNAB levels using assay 2 indicated additional metastases in 5 LNs of the sTgAb+ patients. Conclusions Factors other than the presence of TgAb-FNAB may contribute to the higher number of metastatic LNs with undetectable Tg-FNAB in the sTgAb+ group. In addition, the measurement of Tg-FNAB using different assays was useful to enhance the diagnosis of metastatic LNs, particularly when cytological and Tg-FNAB results are discordant.
DOI: 10.6084/m9.figshare.14272637
title: Dental surgeons' work in the identification of child and adolescent abuse in primary health care

description: We analyzed the role of the dental surgeon in identifying child and adolescent maltreatment in primary care and associated factors. A cross-sectional study of 212 dentist-surgeons in 85 municipalities of Ceará. A questionnaire containing socio-demographic variables and information on knowledge, identification, and notification of maltreatment was sent to participants by the municipal manager. Bivariate and multivariate logistic regression analyses were performed. Few professionals identified maltreatment, indicating the difficulties of this practice. Analysis showed that having a post-graduation degree and knowing the notification form increased the chances of identifying maltreatment.
DOI: 10.6084/m9.figshare.7507688.v1
title: Analysis of reverse heat transfer for conventional and optimized lubri-cooling methods during tangential surface grinding of ABNT 1020 steel

description: Abstract A numerical thermal model was developed to evaluate the heat flux which is conducted to a rectangular workpiece of steel plate ABNT 1020, thus making it possible to compute the maximum temperature in the grinding surface, taking into account the rectangular distribution of heat flux, the thermal properties of the grinding wheel conventional Al2O3, the piece to be machined and the lubri-refrigerating fluid. The finite volume method was employed for the discretization of the direct thermal problem from the heat diffusion equation associated with the two-dimensional problem of heat conduction in transient regime. The inverse thermal problem was solved by the Golden Section technique. The thermal flux, when compared to the conventional technique of method of application fluid, was reduced by 84.0% in the practices performed with cutting depth of 30µm, at 74.0% in practices with cutting depth of 45µm and 61.2% in the aggressive practices of 60µm, thus demonstrating the applicability of the optimized method for fluid application.
DOI: 10.6084/m9.figshare.8127944
title: POST-HARVEST QUALITY OF OZONATED MACAUBA FRUITS FOR BIODIESEL PRODUCTION

description: ABSTRACT The presence of microorganisms, especially during storage, can lead to the rapid deterioration of macauba fruits (Acrocomia aculeata) and reduce the quality of extracted oil for biodiesel production. An alternative to ensure the quality of the oil is the use of ozone gas, a oxidizing agent that has high antimicrobial and sanitizing power. The objective of this study was to evaluate the influence of high concentrations of ozone gas on macaúba fruit and its effect on the quality of the oil throughout storage for the production of biodiesel. Ozonation was performed 20 days after harvest using fruits with and without the epicarp. Ozone was applied at a concentration of 18.0 mg L-1 and a flow of 1.5 L min-1 for 10 h. After ozonation, the fruits were stored for different periods, and the physical-chemical parameters of the oil were evaluated. The ozonation of fruits without the epicarp visually reduced microorganism attack. In general, the ozonation process of macauba fruits maintained the visual characteristics of the fruits and the physical-chemical characteristics of the oil for biodiesel production compared to untreated fruits. The average acidity values of the oil were lower in the treatments with the ozone gas. Removal of the epicarp tends to facilitate the ozonation process, potentially by improving gas penetration into the fruit.
DOI: 10.6084/m9.figshare.7678346
title: The oral health policy in a municipality of Bahia: the agents of state bureaucracy

description: ABSTRACT This study aimed to characterize Oral Health Coordinators (OHC) involved in the implantation of the Brazilian Oral Health Policy (BOHP) in a municipality of Bahia, exemplary case, between 1997-2015. A qualitative approach case study was carried out, based on the Bourdieu theoretical, through in-depth interviews with six OHC, with an average of 45 years of age. Their professional trajectories were analyzed from the following categories: social origin, professional training, professional trajectory and insertion, and trajectory in the bureaucratic field. The majority of them graduated from public institutions and presented an upward trajectory in the bureaucratic field. The insertion in management was influenced by dispositions, network relations, and professional performance in Family Health Strategy (FHS). Professional qualification seems to be a differentiating aspect. Post-graduation in public health represented a greater possibility of insertion in the FHS. The management team maintained clinical practice. The support of municipal management and health was highlighted by almost all interviewees. The BOHP contributed to the expansion of the oral health network, however, the main propositions were implanted previously. The importance of management in the BOHP implementation is evident and it is recommended to carry out similar analysis of other cases to identify regularities that contribute to the explanation of the different degrees of BOHP implementation.
DOI: 10.6084/m9.figshare.7678346.v1
title: The oral health policy in a municipality of Bahia: the agents of state bureaucracy

description: ABSTRACT This study aimed to characterize Oral Health Coordinators (OHC) involved in the implantation of the Brazilian Oral Health Policy (BOHP) in a municipality of Bahia, exemplary case, between 1997-2015. A qualitative approach case study was carried out, based on the Bourdieu theoretical, through in-depth interviews with six OHC, with an average of 45 years of age. Their professional trajectories were analyzed from the following categories: social origin, professional training, professional trajectory and insertion, and trajectory in the bureaucratic field. The majority of them graduated from public institutions and presented an upward trajectory in the bureaucratic field. The insertion in management was influenced by dispositions, network relations, and professional performance in Family Health Strategy (FHS). Professional qualification seems to be a differentiating aspect. Post-graduation in public health represented a greater possibility of insertion in the FHS. The management team maintained clinical practice. The support of municipal management and health was highlighted by almost all interviewees. The BOHP contributed to the expansion of the oral health network, however, the main propositions were implanted previously. The importance of management in the BOHP implementation is evident and it is recommended to carry out similar analysis of other cases to identify regularities that contribute to the explanation of the different degrees of BOHP implementation.
DOI: 10.6084/m9.figshare.8127944.v1
title: POST-HARVEST QUALITY OF OZONATED MACAUBA FRUITS FOR BIODIESEL PRODUCTION

description: ABSTRACT The presence of microorganisms, especially during storage, can lead to the rapid deterioration of macauba fruits (Acrocomia aculeata) and reduce the quality of extracted oil for biodiesel production. An alternative to ensure the quality of the oil is the use of ozone gas, a oxidizing agent that has high antimicrobial and sanitizing power. The objective of this study was to evaluate the influence of high concentrations of ozone gas on macaúba fruit and its effect on the quality of the oil throughout storage for the production of biodiesel. Ozonation was performed 20 days after harvest using fruits with and without the epicarp. Ozone was applied at a concentration of 18.0 mg L-1 and a flow of 1.5 L min-1 for 10 h. After ozonation, the fruits were stored for different periods, and the physical-chemical parameters of the oil were evaluated. The ozonation of fruits without the epicarp visually reduced microorganism attack. In general, the ozonation process of macauba fruits maintained the visual characteristics of the fruits and the physical-chemical characteristics of the oil for biodiesel production compared to untreated fruits. The average acidity values of the oil were lower in the treatments with the ozone gas. Removal of the epicarp tends to facilitate the ozonation process, potentially by improving gas penetration into the fruit.
DOI: 10.6084/m9.figshare.7519409
title: Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome

description: ABSTRACT Objective The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses. Materials and methods HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. One group (9 Wistar rats) with HF received 1.0 µg of T4/100 g of body weight for five consecutive days (HFS/T4); the other group (9 Wistar rats) received isotonic saline solution (HFS/S). The animals were sacrificed after this treatment and examined for signs of HF. Samples from the left ventricles of these animals were analyzed by RT-qPCR for the expression of Serca2 and Ryr2 genes. Results Rats with HF developed euthyroid sick syndrome (ESS) and treatment with T4 restored the T3 values to the Sham level and increased Serca2 and Ryr2 gene expression, thereby demonstrating a possible benefit of T4 treatment for heart function in ESS associated with HF. Conclusion The T4 treatment can potentially normalize the levels of T3 as well elevated Serca2 and Ryr2 gene expression in the myocardium in heart failure rats with euthyroid sick syndrome.
DOI: 10.6084/m9.figshare.7519409.v1
title: Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome

description: ABSTRACT Objective The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses. Materials and methods HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. One group (9 Wistar rats) with HF received 1.0 µg of T4/100 g of body weight for five consecutive days (HFS/T4); the other group (9 Wistar rats) received isotonic saline solution (HFS/S). The animals were sacrificed after this treatment and examined for signs of HF. Samples from the left ventricles of these animals were analyzed by RT-qPCR for the expression of Serca2 and Ryr2 genes. Results Rats with HF developed euthyroid sick syndrome (ESS) and treatment with T4 restored the T3 values to the Sham level and increased Serca2 and Ryr2 gene expression, thereby demonstrating a possible benefit of T4 treatment for heart function in ESS associated with HF. Conclusion The T4 treatment can potentially normalize the levels of T3 as well elevated Serca2 and Ryr2 gene expression in the myocardium in heart failure rats with euthyroid sick syndrome.
DOI: 10.6084/m9.figshare.9986537
title: Descriptive analysis of spending on hospitalizations due to ambulatory care sensitive conditions

description: Abstract Background Funding is a problem present throughout the history of the Brazilian Unified Health System (SUS). Health spending in Brazil have always been insufficient to ensure the principles of SUS. Objective To analyze spending on hospitalizations due to ambulatory care for sensitive conditions (HACSC) and their impact on health expenditures. Method This study analyzed spending on health in São Leopoldo, RS, between 2003 and 2012. It is an ecological study using data available from the Informatics Department of Brazil’s National Unified Health System through the Hospital Information System and the Information System of Public Health Budget. Results São Leopoldo’s total health expenditure increased 70.91% in the period, growing 58.52% in per capita spending, and only 21.75% in expenses for primary health care (PHC). Spending on HACSC increased 16.30% and total spending with hospitalization decreased 3.54%. Compared to total health expenditure, the spending on HACSC represented 2.57%, in 2003, and 1.75%, in 2012. Comparing to expenses for PHC, the average spending on HACSC represented 19.43% of expenses on PHC. Conclusion There was an increase in per capita spending on health, but still insufficient. The amounts spent on the ICSAP could represent a significant savings to the health system.
DOI: 10.6084/m9.figshare.9986537.v1
title: Descriptive analysis of spending on hospitalizations due to ambulatory care sensitive conditions

description: Abstract Background Funding is a problem present throughout the history of the Brazilian Unified Health System (SUS). Health spending in Brazil have always been insufficient to ensure the principles of SUS. Objective To analyze spending on hospitalizations due to ambulatory care for sensitive conditions (HACSC) and their impact on health expenditures. Method This study analyzed spending on health in São Leopoldo, RS, between 2003 and 2012. It is an ecological study using data available from the Informatics Department of Brazil’s National Unified Health System through the Hospital Information System and the Information System of Public Health Budget. Results São Leopoldo’s total health expenditure increased 70.91% in the period, growing 58.52% in per capita spending, and only 21.75% in expenses for primary health care (PHC). Spending on HACSC increased 16.30% and total spending with hospitalization decreased 3.54%. Compared to total health expenditure, the spending on HACSC represented 2.57%, in 2003, and 1.75%, in 2012. Comparing to expenses for PHC, the average spending on HACSC represented 19.43% of expenses on PHC. Conclusion There was an increase in per capita spending on health, but still insufficient. The amounts spent on the ICSAP could represent a significant savings to the health system.
DOI: 10.6084/m9.figshare.14272637.v1
title: Dental surgeons' work in the identification of child and adolescent abuse in primary health care

description: We analyzed the role of the dental surgeon in identifying child and adolescent maltreatment in primary care and associated factors. A cross-sectional study of 212 dentist-surgeons in 85 municipalities of Ceará. A questionnaire containing socio-demographic variables and information on knowledge, identification, and notification of maltreatment was sent to participants by the municipal manager. Bivariate and multivariate logistic regression analyses were performed. Few professionals identified maltreatment, indicating the difficulties of this practice. Analysis showed that having a post-graduation degree and knowing the notification form increased the chances of identifying maltreatment.
DOI: 10.6084/m9.figshare.14272639
title: Conceptions of economic development and the understanding of the role of tourism in poverty reduction

description: Abstract This paper aims to highlight the context that made possible the formation of a view that assigns to tourism the ability to reduce poverty, widely used by major multilateral international development agencies (World Bank, ILO, UNWTO, UN-UNDP). To this end, this research sought answers in understanding economic development through two main analytical lines of thought: the neoliberal current and its counterpoint, the "critical" current of development. Using the main features of both perspectives, we attempted to discuss the contribution of each line of thought to understand positive and negative aspects of the current that associates tourism with the ability to fight poverty. At the same time, it was briefly presented how each agency understands poverty, its causes, and the role of tourism in reducing it. The objective of the research was therefore to confer critical content on the subject and raise discussions in a current scenario of great relevance to the epistemological and empirical field of tourism.
DOI: 10.6084/m9.figshare.7512914.v1
title: Analysis of urban solid waste costs determinants in Brazilian state capitals

description: Abstract This article aims to analyze and discuss factors that directly influence the per capita cost of urban solid waste in the Brazilian capitals. Information was collected on the costs of solid waste and specified a multivariate econometric model to understand its determinants. It was concluded that the waste costs depend on the management method elected (existence of selective collection), but are strongly influenced by the municipality management. Contrary to what the neoclassical microeconomic literature says, in the case of solid waste, in Brazilians capitals, the existence of the private sector in the service operation tends to bring increased pressure from higher services costs offered when operated by the government or mixed form.
DOI: 10.6084/m9.figshare.7519412
title: Interactions between prolactin and kisspeptin to control reproduction

description: ABSTRACT Prolactin is best known for its effects of stimulating mammary gland development and lactogenesis. However, prolactin is a pleiotropic hormone that is able to affect several physiological functions, including fertility. Prolactin receptors (PRLRs) are widely expressed in several tissues, including several brain regions and reproductive tract organs. Upon activation, PRLRs may exert prolactin’s functions through several signaling pathways, although the recruitment of the signal transducer and activator of transcription 5 causes most of the known effects of prolactin. Pathological hyperprolactinemia is mainly due to the presence of a prolactinoma or pharmacological effects induced by drugs that interact with the dopamine system. Notably, hyperprolactinemia is a frequent cause of reproductive dysfunction and may lead to infertility in males and females. Recently, several studies have indicated that prolactin may modulate the reproductive axis by acting on specific populations of hypothalamic neurons that express the Kiss1 gene. The Kiss1 gene encodes neuropeptides known as kisspeptins, which are powerful activators of gonadotropin-releasing hormone neurons. In the present review, we will summarize the current knowledge about prolactin’s actions on reproduction. Among other aspects, we will discuss whether the interaction between prolactin and the Kiss1-expressing neurons can affect reproduction and how kisspeptins may become a novel therapeutic approach to treat prolactin-induced infertility.
DOI: 10.6084/m9.figshare.7519412.v1
title: Interactions between prolactin and kisspeptin to control reproduction

description: ABSTRACT Prolactin is best known for its effects of stimulating mammary gland development and lactogenesis. However, prolactin is a pleiotropic hormone that is able to affect several physiological functions, including fertility. Prolactin receptors (PRLRs) are widely expressed in several tissues, including several brain regions and reproductive tract organs. Upon activation, PRLRs may exert prolactin’s functions through several signaling pathways, although the recruitment of the signal transducer and activator of transcription 5 causes most of the known effects of prolactin. Pathological hyperprolactinemia is mainly due to the presence of a prolactinoma or pharmacological effects induced by drugs that interact with the dopamine system. Notably, hyperprolactinemia is a frequent cause of reproductive dysfunction and may lead to infertility in males and females. Recently, several studies have indicated that prolactin may modulate the reproductive axis by acting on specific populations of hypothalamic neurons that express the Kiss1 gene. The Kiss1 gene encodes neuropeptides known as kisspeptins, which are powerful activators of gonadotropin-releasing hormone neurons. In the present review, we will summarize the current knowledge about prolactin’s actions on reproduction. Among other aspects, we will discuss whether the interaction between prolactin and the Kiss1-expressing neurons can affect reproduction and how kisspeptins may become a novel therapeutic approach to treat prolactin-induced infertility.
DOI: 10.6084/m9.figshare.5885617
title: Growth Dynamics of Araucaria after Management Interventions in Natural Forest

description: ABSTRACT The objective of this study was to evaluate the effect of selective logging on the growth dynamics of Araucaria angustifolia in a natural forest of Rio Grande do Sul state, Brazil. Treatments were based on percentage reduction of the basal area per DBH class, namely, T0 (control) = 0%; T1 (light selective logging) = reduction of 20-30%; T2 (moderate selective logging) = reduction of 40-50%. Data were obtained prior to the management interventions and four, eight and 13 years after selective logging. Changes between treatments were assessed using the following parameters: absolute density, absolute dominance, importance value index, and growth rates. Results show that population reduction and canopy opening provided greater recruitment and higher growth rates for araucaria in the management treatments (T1 and T2) compared with those of the control treatment (T0). These results reinforce that management practices are necessary for the continuous development of araucaria in this forest formation.