cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13145/bacdive105150.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105151.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105152.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105153.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105154.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105155.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105156.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105157.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105158.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105159.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105160.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105161.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.13145/bacdive105162.20191129.4.1
title: Gordonia sp.

description: The range of data encompasses taxonomy, morphology, physiology, sampling and concomitant environmental conditions as well as molecular biology.
DOI: 10.6084/m9.figshare.17010244.v1
title: Additional file 14 of A systems genetics approach reveals PbrNSC as a regulator of lignin and cellulose biosynthesis in stone cells of pear fruit

description: Additional file 14. List of selected stone cell-related genes in previously reported GWAS and QTL regions.
DOI: 10.6084/m9.figshare.23907651
title: <b>Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses</b>

description: These files contain the validation data for the development of the PainFace software, an automated mouse grimace platform.
DOI: 10.6084/m9.figshare.18071032.v1
title: Additional file 1 of LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway

description: Additional file 1. Untrimmed whole western blots for Figure 4B.
DOI: 10.5281/zenodo.10659117
title: craterocephalus_fluviatilis_zanfona_1.fasta.gz

description: .
DOI: 10.5281/zenodo.10659118
title: craterocephalus_fluviatilis_zanfona_1.fasta.gz

description: .
DOI: 10.6084/m9.figshare.18071032
title: Additional file 1 of LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway

description: Additional file 1. Untrimmed whole western blots for Figure 4B.
DOI: 10.6084/m9.figshare.14401165
title: PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals

description: Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily from migratory ducks) and Charadriiformes (primarily from shorebirds). However, little attention has been given to the transmission ability of H3N8 avian influenza viruses among mammals. Here, we study the potential human health threat and the molecular basis of mammalian transmissibility of H3N8 avian influenza viruses isolated from wild bird reservoirs. We classified eight H3N8 viruses into seven different genotypes based on genomic diversity. Six of eight H3N8 viruses isolated naturally from wild birds have acquired the ability to bind to the human-type receptor. However, the affinity for α-2,6-linked SAs was lower than that for α-2,3-linked SAs. Experiments on guinea pigs demonstrated that three viruses transmitted efficiently to direct-contact guinea pigs without prior adaptation. Notably, one virus transmitted efficiently via respiratory droplets in guinea pigs but not in ferrets. We further found that the PB1 S524G mutation conferred T222 virus airborne transmissibility between ferrets. We also determined that the 524G mutant increased viral pathogenicity slightly in mice compared with the WT (wild type). Based on these results, we elucidated the potential human health threat and molecular basis of mammalian transmissibility of H3N8 influenza viruses. We emphasized the need for continued surveillance of the H3N8 influenza viruses circulating in birds.
DOI: 10.17028/rd.lboro.14401295
title: Supporting Information files for In-situ Synthesis of Cross-linked Imidazolium Functionalized Poly(styrene-b-isobutylene-b-styrene) for Anion Exchange Membranes

description: Supporting Information files for In-situ Synthesis of Cross-linked Imidazolium Functionalized Poly(styrene-b-isobutylene-b-styrene) for Anion Exchange Membranes <br>The cross-linked imidazolium functionalized anion-exchange membranes is in-situ prepared via reaction of chloromethylated poly(styrene-b-isobutylene-b-styrene) with 1,1’-(1,6-hexanediyl)bisimidazole and N-methylimidazole. The composite membranes of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) with a small amount of modified graphene oxide grafted with octadecyl and propyl phenyl imidazolium could be further prepared. These membranes exhibit significantly high chemical stability and ionic conductivity (σ), marked by low methanol permeability, together with improved dynamic mechanical properties. The ionic conductivity of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) reaches 2.09 × 10−2 S cm−1 at 80 °C by introduction of 0.5 wt% loading of modified graphene oxide. This membrane also behaves an excellent chemical stability and σ can remain ca. 82% of the original value after immerged in strong alkaline medium (2 M NaOH) at 60 °C for 500 h, which is almost the same as that (ca. 82%) of commercial Nafion 115 in acid medium (2 M H2SO4) at 60 °C for 500 h. The cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) is characterized as a promising anion exchange membrane materials in fuel cell for its high ionic conductivity, chemical stability and low methanol permeability.<br>
DOI: 10.17028/rd.lboro.14401295.v1
title: Supporting Information files for In-situ Synthesis of Cross-linked Imidazolium Functionalized Poly(styrene-b-isobutylene-b-styrene) for Anion Exchange Membranes

description: Supporting Information files for In-situ Synthesis of Cross-linked Imidazolium Functionalized Poly(styrene-b-isobutylene-b-styrene) for Anion Exchange Membranes <br>The cross-linked imidazolium functionalized anion-exchange membranes is in-situ prepared via reaction of chloromethylated poly(styrene-b-isobutylene-b-styrene) with 1,1’-(1,6-hexanediyl)bisimidazole and N-methylimidazole. The composite membranes of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) with a small amount of modified graphene oxide grafted with octadecyl and propyl phenyl imidazolium could be further prepared. These membranes exhibit significantly high chemical stability and ionic conductivity (σ), marked by low methanol permeability, together with improved dynamic mechanical properties. The ionic conductivity of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) reaches 2.09 × 10−2 S cm−1 at 80 °C by introduction of 0.5 wt% loading of modified graphene oxide. This membrane also behaves an excellent chemical stability and σ can remain ca. 82% of the original value after immerged in strong alkaline medium (2 M NaOH) at 60 °C for 500 h, which is almost the same as that (ca. 82%) of commercial Nafion 115 in acid medium (2 M H2SO4) at 60 °C for 500 h. The cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) is characterized as a promising anion exchange membrane materials in fuel cell for its high ionic conductivity, chemical stability and low methanol permeability.<br>
DOI: 10.6084/m9.figshare.17010232.v1
title: Additional file 10 of A systems genetics approach reveals PbrNSC as a regulator of lignin and cellulose biosynthesis in stone cells of pear fruit

description: Additional file 10. The reported distant eQTL for genes in stone cell modules.
DOI: 10.6084/m9.figshare.5488588
title: EgoNet identifies differential ego-modules and pathways related to prednisolone resistance in childhood acute lymphoblastic leukemia

description: <b>Purpose:</b> To extract feature ego-modules and pathways in childhood acute lymphoblastic leukemia (ALL) resistant to prednisolone treatment, and further to explore the mechanisms behind prednisolone resistance. <b>Materials and methods:</b> EgoNet algorithm was used to identify candidate ego-network modules, mainly via constructing differential co-expression network (DCN); selecting ego genes; collecting ego-network modules; refining candidate modules. Afterwards, statistical significance was calculated for these candidate modules. Biological functions of differential ego-network modules were identified using Reactome database. To verify this proposed method can lead to truly positive findings in clinical settings, support vector machine (SVM) was utilized to compute the AUC values for each significant pathway using 3-fold cross-validation method. To predict the reliability of our findings, another established method (attract) was used to identify the differential attractor modules using the same microarray profile. <b>Results:</b> After eliminating the modules with classification accuracy &lt; 0.9 and node number &lt; 15, only ego-network module 30 was eligible. After significance calculation, module 30 was significant. Module 30 was enriched in APC/C-mediated degradation of cell cycle proteins. The AUC for the significant pathway of APC/C-mediated degradation of cell cycle proteins was 0.915. Although the attract method obtained more modules, the module identified by our proposed method owned more gene nodes, and had more classification ability (AUC = 0.915). <b>Conclusion:</b> One differential ego-network module identified in childhood ALL resistance to prednisolone based on DCN and EgoNet, might be helpful to reveal the mechanisms underlying prednisolone resistance in childhood ALL.
DOI: 10.6084/m9.figshare.19120312
title: Additional file 10 of Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

description: Additional file 10. 823-RNA-seq GSEA gene list.
DOI: 10.6084/m9.figshare.17022769.v1
title: Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway

description: Osteosarcoma is one of the common primary malignant tumors of bone in adolescents. Human umbilical vein endothelial cells (HUVECs) derived exosomes are associated with osteosarcoma cell stemness. Little is known about the function of HUVECs-exosomes in osteosarcoma cell stemness. This work aimed to investigate the mechanism of action of HUVECs-exosomes in regulating stem cell-like phenotype of osteosarcoma cells. HUVECs were treated with GW4869 (exosome inhibitor). Human osteosarcoma cells (U2OS and 143B) were treated with HUVECs supernatant, HUVECs-exosomes with or without RO4929097 (γ secretase inhibitor, used to block Notch signaling pathway). We found that HUVECs supernatant and HUVECs-exosomes enhanced the proportions of STRO-1<sup>+</sup>CD117<sup>+</sup> cells and the expression of stem cell-related proteins Oct4 and Sox2. Both HUVECs supernatant and HUVECs-exosomes promoted the sarcosphere formation efficiency of U2OS and 143B cells. These stem-like phenotypes of U2OS and 143B cells conferred by HUVECs-exosomes were repressed by GW4869. Moreover, HUVECs-exosomes promoted the expression of Notch1, Hes1 and Hey1 in the U2OS and 143B cells. RO4929097 treatment reversed the impact of HUVECs-exosomes on Notch1, Hes1 and Hey1 expression by inhibiting Notch1 signaling pathway. In conclusion, this work demonstrated that HUVECs-exosomes promoted cell stemness in osteosarcoma through activating Notch signaling pathway. Thus, our data reveals the mechanism of HUVECs-exosomes in regulating cell stemness of osteosarcoma, and provides a theoretical basis for osteosarcoma treatment by exosomes.
DOI: 10.6084/m9.figshare.14401654.v1
title: LncRNA lnc_13814 promotes the cells apoptosis in granulosa cells of duck by acting as apla-miR-145-4 sponge

description: Follicle development is a vital factor which determines the reproductive performance of poultry. Long noncoding RNAs (lncRNAs) have been reported to maintain animal reproductive function and play key roles in ovarian development and hormone secretion. But the regulatory mechanism of lncRNAs in duck follicle development has seldom been reported. In this study, to better explore the molecular mechanism of follicle development in ducks, the follicular lncRNA was sequenced and analyzed. A total of 9,551 lncRNAs were predicted in the duck follicles. Four hundred and forty-five lncRNAs were differentially expressed between the white follicles and yellow follicles. The results of our studies showed that lnc_13814 promoted cell apoptosis in duck GCs. Furthermore, the bioinformatics analysis results demonstrated that lnc_13814 was involved in a lncRNA-miRNA-mRNA coexpression network and it was observed to sponge two follicle-related miRNAs by a luciferase activity assay. Moreover, we found that overexpression of lnc_13814 significantly increased DNA damage inducible transcript 3 (DDIT3) expression and downregulated GCs apoptosis. Finally, we found that lnc_13814 directly binds to and inhibits apla-mir-145-4; then, lnc_13814 increases the expression of DDIT3 and up-regulates GCs apoptosis. Taken together, our findings demonstrate that lncRNAs have potential effects on duck ovarian follicles and lncRNAs may represent a new approach to understand follicular development.
DOI: 10.6084/m9.figshare.12291728.v1
title: Additional file 2 of ICGEC: a comparative method for measuring epigenetic conservation of genes via the integrated signal from multiple histone modifications between cell types

description: Additional file 2: Table S1. The download links to the histone modification data used in this study. Table S2. The download links to the RNA sequencing data used in this study.
DOI: 10.6084/m9.figshare.19120312.v1
title: Additional file 10 of Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

description: Additional file 10. 823-RNA-seq GSEA gene list.
DOI: 10.6084/m9.figshare.20168915.v1
title: Additional file 8 of Oxidoreduction potential controlling for increasing the fermentability of enzymatically hydrolyzed steam-exploded corn stover for butanol production

description: Additional file 8. Simulation of metabolic flux of the ATP generation/consumption reaction of C. acetobutylicum ATCC 824 strain under the different conditions.
DOI: 10.6084/m9.figshare.20168307
title: Additional file 5 of Differential proteomics of placentas reveals metabolic disturbance and oxidative damage participate yak spontaneous miscarriage during late pregnancy

description: Additional file 5. Down-regulated differentially expressed proteins and their annotation information.
DOI: 10.6084/m9.figshare.20168301
title: Additional file 3 of Differential proteomics of placentas reveals metabolic disturbance and oxidative damage participate yak spontaneous miscarriage during late pregnancy

description: Additional file 3. Trusted proteins and their annotation information.
DOI: 10.6084/m9.figshare.20168310
title: Additional file 6 of Differential proteomics of placentas reveals metabolic disturbance and oxidative damage participate yak spontaneous miscarriage during late pregnancy

description: Additional file 6. Gene ontology enrichment results for the up-regulated differentially expressed proteins.
DOI: 10.6084/m9.figshare.20168909
title: Additional file 6 of Oxidoreduction potential controlling for increasing the fermentability of enzymatically hydrolyzed steam-exploded corn stover for butanol production

description: Additional file 6. Details of compounds in the model.
DOI: 10.6084/m9.figshare.20168912
title: Additional file 7 of Oxidoreduction potential controlling for increasing the fermentability of enzymatically hydrolyzed steam-exploded corn stover for butanol production

description: Additional file 7. The flux of each reaction at different times under different conditions.
DOI: 10.6084/m9.figshare.19120339.v1
title: Additional file 9 of Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

description: Additional file 9. 823-RNA-seq Gene_differential_expression.
DOI: 10.6084/m9.figshare.14401654
title: LncRNA lnc_13814 promotes the cells apoptosis in granulosa cells of duck by acting as apla-miR-145-4 sponge

description: Follicle development is a vital factor which determines the reproductive performance of poultry. Long noncoding RNAs (lncRNAs) have been reported to maintain animal reproductive function and play key roles in ovarian development and hormone secretion. But the regulatory mechanism of lncRNAs in duck follicle development has seldom been reported. In this study, to better explore the molecular mechanism of follicle development in ducks, the follicular lncRNA was sequenced and analyzed. A total of 9,551 lncRNAs were predicted in the duck follicles. Four hundred and forty-five lncRNAs were differentially expressed between the white follicles and yellow follicles. The results of our studies showed that lnc_13814 promoted cell apoptosis in duck GCs. Furthermore, the bioinformatics analysis results demonstrated that lnc_13814 was involved in a lncRNA-miRNA-mRNA coexpression network and it was observed to sponge two follicle-related miRNAs by a luciferase activity assay. Moreover, we found that overexpression of lnc_13814 significantly increased DNA damage inducible transcript 3 (DDIT3) expression and downregulated GCs apoptosis. Finally, we found that lnc_13814 directly binds to and inhibits apla-mir-145-4; then, lnc_13814 increases the expression of DDIT3 and up-regulates GCs apoptosis. Taken together, our findings demonstrate that lncRNAs have potential effects on duck ovarian follicles and lncRNAs may represent a new approach to understand follicular development.
DOI: 10.6084/m9.figshare.19120339
title: Additional file 9 of Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

description: Additional file 9. 823-RNA-seq Gene_differential_expression.
DOI: 10.6084/m9.figshare.20168319
title: Additional file 9 of Differential proteomics of placentas reveals metabolic disturbance and oxidative damage participate yak spontaneous miscarriage during late pregnancy

description: Additional file 9. Kyoto encyclopaedia of genes and genomes enrichment results for the down-regulated differentially expressed proteins.
DOI: 10.6084/m9.figshare.20168915
title: Additional file 8 of Oxidoreduction potential controlling for increasing the fermentability of enzymatically hydrolyzed steam-exploded corn stover for butanol production

description: Additional file 8. Simulation of metabolic flux of the ATP generation/consumption reaction of C. acetobutylicum ATCC 824 strain under the different conditions.
DOI: 10.6084/m9.figshare.14913471.v1
title: Additional file 5 of Bioinformatics integrated analysis to investigate candidate biomarkers and associated metabolites in osteosarcoma

description: Additional file 5: Table S3. The five KEGG metabolites ID corresponding to these 10 compounds.
DOI: 10.6084/m9.figshare.14913465
title: Additional file 3 of Bioinformatics integrated analysis to investigate candidate biomarkers and associated metabolites in osteosarcoma

description: Additional file 3: Table S1. Survival data and results for survival analysis of all feature genes.
DOI: 10.6084/m9.figshare.24085107.v3
title: Cross-tolerance evolution driven by selection on heat tolerance in <i>Drosophila subobscura</i>

description: Evolution of heat tolerance is a crucial mechanism for the adaptive response to global warming, but it depends on the genetic variance harbored by populations and the thermal stress intensity in nature. Selection experiments on heat tolerance have been key to understanding the heat tolerance evolution but the effect of variable heat stress intensity on the correlated responses of resistance traits has not been explored. Here, the effects of heat intensity selection (fast and slow ramping temperatures) for increasing knockdown temperature in <i>Drosophila subobscura</i> were evaluated on the knockdown time at different stressful temperatures (35, 36, 37, and 38 ºC), the thermal-death-time curves (TDT curves), the desiccation and starvation resistance. Correlated evolution was found for these four resistance traits in <i>D. subobscura</i>, which demonstrates that the evolutionary response to tolerate higher temperatures also confers the capacity to tolerate other stress such as desiccation and starvation. However, these correlated responses depended on the intensity of thermal selection and sex, which could limit our capacities to transfer these findings to natural scenarios. Nevertheless, this study reaffirms the value of the experimental evolutionary approach to explore and understand the adaptive responses of natural populations to global warming.
DOI: 10.25345/c5930p596
title: MassIVE MSV000094086 - Lacritin N-104 affinity purification of P. aeruginosa surface proteins
title: The precleared whole cell P. aeruginosa PA14 lysates underwent an overnight incubation with bead-immobilized N-104 peptide (or C-95 as a negative control peptide) under physiological conditions. Subsequent steps included washes and a gradual step-gradient elution ranging from 50 to 500 mM KCl. The eluate obtained at 500 mM KCl was then analyzed using tandem mass spectrometry to identify PA14 proteins that bind to N-104.
DOI: 10.6084/m9.figshare.22790314
title: Additional file 1 of The irreplaceable role of medical massive open online courses in China during the COVID-19 pandemic

description: Additional file 1.
DOI: 10.6084/m9.figshare.19120301.v1
title: Additional file 2 of RNA-Seq with a novel glabrous-ZM24fl reveals some key lncRNAs and the associated targets in fiber initiation of cotton

description: Additional file 2. List of lncRNAs identified from ovules of two lines during fiber initiation stage.
DOI: 10.6084/m9.figshare.20168909.v1
title: Additional file 6 of Oxidoreduction potential controlling for increasing the fermentability of enzymatically hydrolyzed steam-exploded corn stover for butanol production

description: Additional file 6. Details of compounds in the model.
DOI: 10.6084/m9.figshare.19120301
title: Additional file 2 of RNA-Seq with a novel glabrous-ZM24fl reveals some key lncRNAs and the associated targets in fiber initiation of cotton

description: Additional file 2. List of lncRNAs identified from ovules of two lines during fiber initiation stage.