cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6235100
title: Amitriptyline and intraoral devices for migraine prevention: a randomized comparative trial

description: ABSTRACT Objectives: Nonpharmacological treatments, such as the Nociceptive Trigeminal Inhibition Tension Suppression System (NTI-tss), are approved for migraine prophylaxis. We aimed at evaluating the effectiveness of the NTI-tss and to compare its efficacy with amitriptyline and with a sham intraoral device in the preventive treatment of migraine. Methods: Consecutive patients with migraine were randomized to receive 25 mg of amitriptyline/day (n = 34), NTI-tss (n = 33) and a non-occlusal splint (n = 30). The headache frequency was evaluated at six and 12 weeks. Results: The amitriptyline group showed, respectively, 60% and 64% reduction in attack frequency at six and 12 weeks (P = 0.000). In the NTI-tss and non-occlusal splint groups, reduction was 39% and 30%, respectively, at six weeks and 48% for both groups at 12 weeks. Conclusions: Amitriptyline proved superior to the NTI-tss and the non-occlusal splint. Despite its approval by the United States Food and Drug Administration, the NTI-tss was not superior to a sham device.
DOI: 10.6084/m9.figshare.6235100.v1
title: Amitriptyline and intraoral devices for migraine prevention: a randomized comparative trial

description: ABSTRACT Objectives: Nonpharmacological treatments, such as the Nociceptive Trigeminal Inhibition Tension Suppression System (NTI-tss), are approved for migraine prophylaxis. We aimed at evaluating the effectiveness of the NTI-tss and to compare its efficacy with amitriptyline and with a sham intraoral device in the preventive treatment of migraine. Methods: Consecutive patients with migraine were randomized to receive 25 mg of amitriptyline/day (n = 34), NTI-tss (n = 33) and a non-occlusal splint (n = 30). The headache frequency was evaluated at six and 12 weeks. Results: The amitriptyline group showed, respectively, 60% and 64% reduction in attack frequency at six and 12 weeks (P = 0.000). In the NTI-tss and non-occlusal splint groups, reduction was 39% and 30%, respectively, at six weeks and 48% for both groups at 12 weeks. Conclusions: Amitriptyline proved superior to the NTI-tss and the non-occlusal splint. Despite its approval by the United States Food and Drug Administration, the NTI-tss was not superior to a sham device.
DOI: 10.6084/m9.figshare.6235097
title: Textile biological sludge treatability and biogas production in UASB reactor under different temperatures

description: ABSTRACT The aim of this work was to evaluate the behavior of a laboratory-scale UASB reactor (16 L) in the treatment of textile biological sludge with biogas production, operating at different temperatures - 35 (mesophilic), 45 and 55ºC (thermophilic) -, with constant hydraulic retention time of 24 h. The UASB reactor was able to treat the textile sludge, being positively influenced by increasing temperature, with greater removals in thermophilic temperatures and high removal rates of all monitored physical and chemical parameters: chemical oxygen demand (COD) (97% at 45 and 55ºC), biochemical oxygen demand (BOD) (95% at 45ºC and 94% at 55ºC), total phosphorus (P-total) (95% at 45 and 55ºC) and total nitrogen (N-total) (94% at 45 and 55ºC). As for biogas production and methane concentration, the highest values were observed at 45ºC. Based on the results, textile sludge treatability and biogas production in UASB are confirmed, with best performance at 45ºC.
DOI: 10.6084/m9.figshare.6235097.v1
title: Textile biological sludge treatability and biogas production in UASB reactor under different temperatures

description: ABSTRACT The aim of this work was to evaluate the behavior of a laboratory-scale UASB reactor (16 L) in the treatment of textile biological sludge with biogas production, operating at different temperatures - 35 (mesophilic), 45 and 55ºC (thermophilic) -, with constant hydraulic retention time of 24 h. The UASB reactor was able to treat the textile sludge, being positively influenced by increasing temperature, with greater removals in thermophilic temperatures and high removal rates of all monitored physical and chemical parameters: chemical oxygen demand (COD) (97% at 45 and 55ºC), biochemical oxygen demand (BOD) (95% at 45ºC and 94% at 55ºC), total phosphorus (P-total) (95% at 45 and 55ºC) and total nitrogen (N-total) (94% at 45 and 55ºC). As for biogas production and methane concentration, the highest values were observed at 45ºC. Based on the results, textile sludge treatability and biogas production in UASB are confirmed, with best performance at 45ºC.
DOI: 10.6084/m9.figshare.6235091
title: The effect of different nasal irrigation solutions following septoplasty and concha radiofrequency: a prospective randomized study

description: Abstract Introduction Nasal irrigation solutions are widely used following endonasal surgery. These irrigation solutions remove infective debris and crusts, reducing the probability of synechia formation, and accelerate mucosal healing. Objective The aim of the present study was to compare the effects of nasal irrigation solutions with different contents following septoplasty and concha radiofrequency. Methods The present study was a prospective, randomized, controlled simple blind study of 120 patients who underwent septoplasty and bilateral concha radiofrequency. Patients were divided into four groups according to the nasal irrigation solution used: tap water, buffered isotonic saline, saline with xylitol, and hypertonic sea water. Patients were examined on the 7th and 15th postoperative days. A saccharine test was applied to determine mucociliary activity preoperatively and on the 7th and 15th postoperative days. Patients were asked about drying and obstruction using a 10 cm visual analog scale. In addition, patients were examined to determine the crusting score. Results There was no significant difference found in the preoperative and 7th and 15th postoperative days' mucociliary clearance times among the four groups. The crusting score was found to be significantly lower in the hypertonic sea water group (p &lt; 0.001). Drying and obstruction on the 7th and 15th postoperative days were found to be significantly more comfortable in the hypertonic sea water group (p &lt; 0.001). Conclusion Hypertonic sea water is the recommended irrigation solution, as it is associated with less crusting, drying, and obstruction in the nose for the postoperative period following septoplasty and concha radiofrequency.
DOI: 10.6084/m9.figshare.6235091.v1
title: The effect of different nasal irrigation solutions following septoplasty and concha radiofrequency: a prospective randomized study

description: Abstract Introduction Nasal irrigation solutions are widely used following endonasal surgery. These irrigation solutions remove infective debris and crusts, reducing the probability of synechia formation, and accelerate mucosal healing. Objective The aim of the present study was to compare the effects of nasal irrigation solutions with different contents following septoplasty and concha radiofrequency. Methods The present study was a prospective, randomized, controlled simple blind study of 120 patients who underwent septoplasty and bilateral concha radiofrequency. Patients were divided into four groups according to the nasal irrigation solution used: tap water, buffered isotonic saline, saline with xylitol, and hypertonic sea water. Patients were examined on the 7th and 15th postoperative days. A saccharine test was applied to determine mucociliary activity preoperatively and on the 7th and 15th postoperative days. Patients were asked about drying and obstruction using a 10 cm visual analog scale. In addition, patients were examined to determine the crusting score. Results There was no significant difference found in the preoperative and 7th and 15th postoperative days' mucociliary clearance times among the four groups. The crusting score was found to be significantly lower in the hypertonic sea water group (p &lt; 0.001). Drying and obstruction on the 7th and 15th postoperative days were found to be significantly more comfortable in the hypertonic sea water group (p &lt; 0.001). Conclusion Hypertonic sea water is the recommended irrigation solution, as it is associated with less crusting, drying, and obstruction in the nose for the postoperative period following septoplasty and concha radiofrequency.
DOI: 10.6084/m9.figshare.6235085
title: Dual-Port Dual-Wideband Annular Slot Antenna with Stable Unidirectional Pattern

description: Abstract This article describes the design of a dual-wideband annular slot antenna. The proposed structure has been optimized to operate in the typical bands of mobile communication systems (0.824-0.960 GHz and 1.710-2.165 GHz). The antenna is designed considering two independent ports with high isolation, one for each operation band, yielding an antenna that exhibits diplexing feature. The final measured results show that the designed antenna exhibits stable radiation pattern over the frequency in both desired bands. The designed antenna has been used to compose a dual-band linear array. Simulation results indicate good performance in both bands for mobile communication systems.
DOI: 10.6084/m9.figshare.6235085.v1
title: Dual-Port Dual-Wideband Annular Slot Antenna with Stable Unidirectional Pattern

description: Abstract This article describes the design of a dual-wideband annular slot antenna. The proposed structure has been optimized to operate in the typical bands of mobile communication systems (0.824-0.960 GHz and 1.710-2.165 GHz). The antenna is designed considering two independent ports with high isolation, one for each operation band, yielding an antenna that exhibits diplexing feature. The final measured results show that the designed antenna exhibits stable radiation pattern over the frequency in both desired bands. The designed antenna has been used to compose a dual-band linear array. Simulation results indicate good performance in both bands for mobile communication systems.
DOI: 10.6084/m9.figshare.6235082
title: Nanopharmaceuticals and Their Applications in Bladder Cancer Therapy: a Mini Review

description: The primary treatment for high-grade non-muscle invasive bladder cancer (NMIBC) is based on surgery by transurethral resection of bladder tumor (TURBT), followed by intravesical immunotherapy with Bacillus Calmette-Guerin (BCG) to prevent recurrence and to reduce the tumor progression. However, BCG therapy shows several undesirable effects. The current treatment on NMIBC is doxorubicin (DOX), but with high toxicity. Our nanotechnology strategy was done through scaffolds for the NMIBC treatment: graphene oxide (GO) and a nanostructured lipid carrier (NLC). A GO hybrid for administration of DOX and small interfering RNA (siRNA) was developed. This hybrids administered in vivo against NMIBC in rats gave absence of lesions. NLC was prepared by using a mixture of two lipids stabilized by a surfactant and DOX by high homogenization pressure technique. In this case showed a 20% of the animals exhibited benign lesions (papillary hyperplasia), however, in the presence of siRNA reached 40% of rats with benignant lesions. These two scaffolds are potential new drugs for DOX for bladder cancer treatment without any cardiotoxicity problems.
DOI: 10.6084/m9.figshare.6235082.v1
title: Nanopharmaceuticals and Their Applications in Bladder Cancer Therapy: a Mini Review

description: The primary treatment for high-grade non-muscle invasive bladder cancer (NMIBC) is based on surgery by transurethral resection of bladder tumor (TURBT), followed by intravesical immunotherapy with Bacillus Calmette-Guerin (BCG) to prevent recurrence and to reduce the tumor progression. However, BCG therapy shows several undesirable effects. The current treatment on NMIBC is doxorubicin (DOX), but with high toxicity. Our nanotechnology strategy was done through scaffolds for the NMIBC treatment: graphene oxide (GO) and a nanostructured lipid carrier (NLC). A GO hybrid for administration of DOX and small interfering RNA (siRNA) was developed. This hybrids administered in vivo against NMIBC in rats gave absence of lesions. NLC was prepared by using a mixture of two lipids stabilized by a surfactant and DOX by high homogenization pressure technique. In this case showed a 20% of the animals exhibited benign lesions (papillary hyperplasia), however, in the presence of siRNA reached 40% of rats with benignant lesions. These two scaffolds are potential new drugs for DOX for bladder cancer treatment without any cardiotoxicity problems.
DOI: 10.6084/m9.figshare.6235076
title: The maturation state of the auditory nerve and brainstem in rats exposed to lead acetate and supplemented with ferrous sulfate

description: Abstract Introduction The literature has reported the association between lead and auditory effects, based on clinical and experimental studies. However, there is no consensus regarding the effects of lead in the auditory system, or its correlation with the concentration of the metal in the blood. Objective To investigate the maturation state of the auditory system, specifically the auditory nerve and brainstem, in rats exposed to lead acetate and supplemented with ferrous sulfate. Methods 30 weanling male rats (Rattus norvegicus, Wistar) were distributed into six groups of five animals each and exposed to one of two concentrations of lead acetate (100 or 400 mg/L) and supplemented with ferrous sulfate (20 mg/kg). The maturation state of the auditory nerve and brainstem was analyzed using Brainstem Auditory Evoked Potential before and after lead exposure. The concentration of lead in blood and brainstem was analyzed using Inductively Coupled Plasma-Mass Spectrometry. Results We verified that the concentration of Pb in blood and in brainstem presented a high correlation (r = 0.951; p &lt; 0.0001). Both concentrations of lead acetate affected the maturation state of the auditory system, being the maturation slower in the regions corresponding to portion of the auditory nerve (wave I) and cochlear nuclei (wave II). The ferrous sulfate supplementation reduced significantly the concentration of lead in blood and brainstem for the group exposed to the lowest concentration of lead (100 mg/L), but not for the group exposed to the higher concentration (400 mg/L). Conclusion This study indicate that the lead acetate can have deleterious effects on the maturation of the auditory nerve and brainstem (cochlear nucleus region), as detected by the Brainstem Auditory Evoked Potentials, and the ferrous sulphate can partially amend this effect.
DOI: 10.6084/m9.figshare.6235076.v1
title: The maturation state of the auditory nerve and brainstem in rats exposed to lead acetate and supplemented with ferrous sulfate

description: Abstract Introduction The literature has reported the association between lead and auditory effects, based on clinical and experimental studies. However, there is no consensus regarding the effects of lead in the auditory system, or its correlation with the concentration of the metal in the blood. Objective To investigate the maturation state of the auditory system, specifically the auditory nerve and brainstem, in rats exposed to lead acetate and supplemented with ferrous sulfate. Methods 30 weanling male rats (Rattus norvegicus, Wistar) were distributed into six groups of five animals each and exposed to one of two concentrations of lead acetate (100 or 400 mg/L) and supplemented with ferrous sulfate (20 mg/kg). The maturation state of the auditory nerve and brainstem was analyzed using Brainstem Auditory Evoked Potential before and after lead exposure. The concentration of lead in blood and brainstem was analyzed using Inductively Coupled Plasma-Mass Spectrometry. Results We verified that the concentration of Pb in blood and in brainstem presented a high correlation (r = 0.951; p &lt; 0.0001). Both concentrations of lead acetate affected the maturation state of the auditory system, being the maturation slower in the regions corresponding to portion of the auditory nerve (wave I) and cochlear nuclei (wave II). The ferrous sulfate supplementation reduced significantly the concentration of lead in blood and brainstem for the group exposed to the lowest concentration of lead (100 mg/L), but not for the group exposed to the higher concentration (400 mg/L). Conclusion This study indicate that the lead acetate can have deleterious effects on the maturation of the auditory nerve and brainstem (cochlear nucleus region), as detected by the Brainstem Auditory Evoked Potentials, and the ferrous sulphate can partially amend this effect.
DOI: 10.6084/m9.figshare.6235067
title: Social representations in intercultural context: the daily life of three Brazilian subsidiaries of multinational companies

description: Abstract The acceleration and development of global business have increased the degree of cultural diversity among professionals in organizations, as well as increased concern about teamwork and multicultural teams, as shown by researchers such as Zhou and Shi (2011)and Chevrier and Viegas-Pires (2013). This article identified and analyzed the social representations built by members of multicultural teams through their intercultural interactions and how these affect the organizational daily life in three subsidiaries of multinational companies in Brazil. Qualitative approach and case study methods were used to collect data using documental research and 33 semi-structured interviews with Brazilian and foreign members of work teams. Using the Theory of Social Representations (TSR) of Moscovici (2004), we identified the main social representations in the context of these Brazilian subsidiaries. The results show commonalities of the three subsidiaries such as: the transnationalization strategies of conciliating global guidelines with local demands, building organizational culture with global elements; the incentive to transform some of the professionals in key positions in global professionals; the understanding that cultural diversity is a capital that can bring many positive results for organizations; and the development of intercultural competencies to facilitate the processes of international mobility. In contrast, there are many communication problems and a lack of concern with the process of intercultural learning and assimilation of knowledge and experience acquired. The conclusions show that despite the problems and challenges, the multicultural teams contribute, through daily interaction, with organizational learning, development and consolidation of culture and global routines in organizations. This article demonstrates that using TSR to analyze the intercultural context can provide a dynamic vision of the interaction and construction of an intercultural routine in multinational companies. In addition, this research demonstrates how common traits can be found in organizational culture of multinational companies with multicultural teams.
DOI: 10.6084/m9.figshare.6235067.v1
title: Social representations in intercultural context: the daily life of three Brazilian subsidiaries of multinational companies

description: Abstract The acceleration and development of global business have increased the degree of cultural diversity among professionals in organizations, as well as increased concern about teamwork and multicultural teams, as shown by researchers such as Zhou and Shi (2011)and Chevrier and Viegas-Pires (2013). This article identified and analyzed the social representations built by members of multicultural teams through their intercultural interactions and how these affect the organizational daily life in three subsidiaries of multinational companies in Brazil. Qualitative approach and case study methods were used to collect data using documental research and 33 semi-structured interviews with Brazilian and foreign members of work teams. Using the Theory of Social Representations (TSR) of Moscovici (2004), we identified the main social representations in the context of these Brazilian subsidiaries. The results show commonalities of the three subsidiaries such as: the transnationalization strategies of conciliating global guidelines with local demands, building organizational culture with global elements; the incentive to transform some of the professionals in key positions in global professionals; the understanding that cultural diversity is a capital that can bring many positive results for organizations; and the development of intercultural competencies to facilitate the processes of international mobility. In contrast, there are many communication problems and a lack of concern with the process of intercultural learning and assimilation of knowledge and experience acquired. The conclusions show that despite the problems and challenges, the multicultural teams contribute, through daily interaction, with organizational learning, development and consolidation of culture and global routines in organizations. This article demonstrates that using TSR to analyze the intercultural context can provide a dynamic vision of the interaction and construction of an intercultural routine in multinational companies. In addition, this research demonstrates how common traits can be found in organizational culture of multinational companies with multicultural teams.
DOI: 10.6084/m9.figshare.6235064
title: Variation in the isotopic composition of striped weakfish Cynoscion guatucupa of the Southwest Atlantic Ocean in response to dietary shifts

description: Abstract The aim of this study was to analyze the isotopic composition in muscle of striped weakfish Cynoscion guatucupa from Southwest Atlantic Ocean in order to evaluate a possible variation in δ13C and δ15N in response to dietary shifts that occur as animals grow. We also explored for isotopic evidence of differences between sample locations. The results showed an agreement between isotope analysis and previous conventional studies. Differences in the isotope composition between sampling location were not observed. A positive relation exists between isotope values and total body length of the animals. The Cluster analysis defined three groups of size classes, validated by the MDS. Differences in the relative consumption of prey species in each size class were also observed performing isotope mixing models (SIAR). Variation in δ15N among size classes would be associated with the consumption of a different type of prey as animals grow. Small striped weakfish feed on small crustaceans and progressively increase their consumption of fish (anchovy, Engraulis anchoita), increasing by this way their isotope values. On the other hand, differences in δ13C values seemed to be related to age-class specific spatial distribution patterns. Therefore, large and small striped weakfish remain specialized but feeding on different prey at different trophic levels. These results contribute to the study of the diet of striped weakfish, improve the isotopic ecology models and highlight on the importance of accounting for variation in the isotopic composition in response to dietary shifts with the size of one of the most important fishery resources in the region.