cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7591382.v1
title: Mammographic over-screening: evaluation based on probabilistic linkage of records databases from the Breast Cancer Information System (SISMAMA)

description: Abstract: The Brazilian Ministry of Health recommends biennial mammographic screening for women aged between 50 and 69 years. Since screening is opportunistic in the country, the actual periodicity varies. This study sought to test a methodology for estimating over-screening due to excessive periodicity, defined as a smaller than recommended interval between exams, and its association with socio-demographic characteristics. A cohort of women who underwent mammography in 2010, and whose result was normal, was assembled through probabilistic linkage SISMAMA records based on a set of personal identifiers. We used data from women living in the micro health region of Juiz de Fora/Lima Duarte/Bom Jardim, Minas Gerais State, Brazil, who were followed in the System until the end of 2012. The rate of over-screening was 150/1,000 women/year (95%CI: 144.9-155.9), affecting 21% of women. Over-screening increased by 24% during Pink October campaigns (adjusted HR = 1.24; 95%CI: 1.15-1.35). The shorter the time passed since the last mammogram, the greater the odds of over-screening. Compared with women who had never had a mammogram prior to 2010, women who had had one in the previous 2 years were two times more likely to be over-screened (adjusted HR = 2.01; 95%CI: 1.74-2.31) whilst those who had had a mammogram ≤ 1 year previously were three times more likely to be over-screened (adjusted HR = 3.27; 95%CI: 2.87-3.73). Over-screening was substantial in this population, excessively exposing women to the risks of screening with no additional benefits and overestimating mammogram coverage. The methodology proved to be successful and should be applied to representative populations in order to guide breast cancer control policies.
DOI: 10.6084/m9.figshare.7591370
title: Knowledge about the Medical Residency among students of the Centro Universitário do Estado do Pará

description: ABSTRACT Medical residency (MR) is a postgraduate course in which learning is based mainly on practice focused on a particular medical specialty. Once the medical student decides to become a specialist, it is important to understand how the selection process works, the number of vacancies available, the steps they need to go through, whether they need to enroll in a preparatory course for the residency, which specialties exist in each service, and the negative and positive aspects of each one, among other inherent aspects. This study aims to identify the knowledge of MR among medical students of the Centro Universitário do Estado do Pará (CESUPA), the main sources of information available on the subject, and their gaps in this knowledge. An observational cross-sectional, exploratory, descriptive, analytical study was carried out with 259 students of the Cesupa medical school. It was observed that 99.6% of the participants hoped to enroll in a medical residency, with the majority stating that they have low and medium knowledge about the subject (49% and 42% respectively). More than 60% had already done some research on the topic, the Internet being the most used source of information. Only 6.6% of participants correctly knew the number of mandatory steps in the selection process, and 89.6% considered it necessary to take a preparatory course. It is concluded there are still gaps in medical students’ knowledge about medical residency programs, and this subject should be further explored in the academic environment, through interventions that will broaden students’ horizons, enabling them to become more apt and critical when it comes to deciding where to take the MR, and how to prepare for it.
DOI: 10.6084/m9.figshare.7591373.v1
title: Synthesis and Cytotoxicity Evaluation of a Series of 3-Alkenyl-2-Hydroxy-1,4-Naphthoquinones Obtained by an Efficient Knoevenagel Condensation

description: A modified and efficient Knoevenagel condensation procedure was developed to synthesize the title compounds using β-alanine and acetic acid as catalysts, showing good to excellent yields. We used lawsone with suitable aliphatic aldehydes including isobutyraldehyde, 3-methyl-butyraldehyde, 2-ethylbutyraldehyde, phenylacetaldehyde, 2-phenyl-propionaldehyde, among others. These compounds were submitted to cytotoxic screening against three tumor cell lines presenting good to excellent cytotoxic profiles.
DOI: 10.7284/121423
title: TSG (Thermosalinograph) data collected during research cruise FK140418 using a Sea-Bird SBE-45 instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591370.v1
title: Knowledge about the Medical Residency among students of the Centro Universitário do Estado do Pará

description: ABSTRACT Medical residency (MR) is a postgraduate course in which learning is based mainly on practice focused on a particular medical specialty. Once the medical student decides to become a specialist, it is important to understand how the selection process works, the number of vacancies available, the steps they need to go through, whether they need to enroll in a preparatory course for the residency, which specialties exist in each service, and the negative and positive aspects of each one, among other inherent aspects. This study aims to identify the knowledge of MR among medical students of the Centro Universitário do Estado do Pará (CESUPA), the main sources of information available on the subject, and their gaps in this knowledge. An observational cross-sectional, exploratory, descriptive, analytical study was carried out with 259 students of the Cesupa medical school. It was observed that 99.6% of the participants hoped to enroll in a medical residency, with the majority stating that they have low and medium knowledge about the subject (49% and 42% respectively). More than 60% had already done some research on the topic, the Internet being the most used source of information. Only 6.6% of participants correctly knew the number of mandatory steps in the selection process, and 89.6% considered it necessary to take a preparatory course. It is concluded there are still gaps in medical students’ knowledge about medical residency programs, and this subject should be further explored in the academic environment, through interventions that will broaden students’ horizons, enabling them to become more apt and critical when it comes to deciding where to take the MR, and how to prepare for it.
DOI: 10.6084/m9.figshare.7591361
title: The new definition of the kilogram in terms of Planck's constant

description: Abstract In 2019, the unity of mass of the International System of Units (SI), the kilogram, will have its definition modified. It will not be anymore the metallic artifact kept in the BIPM building, in the neighborhood of Paris, to be based on Planck's constant (h). What is the need for this change? And how the measurements will be done? These are some of the questions that will be answered at this communication, where we describe the operation of the experiment named Watt Balance used in the new way to realize the unity of mass. Besides that, we will describe how we assembled a Balance for teaching purposes, used in talks about the theme. The topic interests everybody, but in special students that take physics courses in any area.
DOI: 10.6084/m9.figshare.7591364
title: Occurrence of Pesticides and PPCPs in Surface and Drinking Water in Southern Brazil: Data on 4-Year Monitoring

description: This study evaluated the environmental occurrence of fifty-one pesticides, pharmaceuticals and personal care products (PPCPs) in surface and drinking water samples collected in southern Brazil over a 4-year period. The method used involved a stage based on solid-phase extraction, followed by liquid chromatography tandem mass spectrometry. Thirty compounds were detected (22 different pesticides and 8 PPCPs) and at least four compounds were identified in more than 50% of the samples. Atrazine was the most frequently detected pesticide and it was found at concentrations between 5 and 49 ng L-1. From PPCPs, glibenclamide, methylparaben and nimesulide were the most commonly detected in both drinking water and surface water samples. Results showed the extent to which traces of pesticides and PPCPs were present in water samples from this region.
DOI: 10.6084/m9.figshare.7591358
title: Investigation of correlation between cytological and histological findings in suspected carcinoma of thyroid

description: ABSTRACT Introduction: The thyroid cytopathologic classification based on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) standardized results derived from fine-needle aspiration (FNA). It has facilitated communication among clinicians, seems to reduce the number of unnecessary thyroidectomies and also improves the quality of malignancy detection. Objective: To evaluate the correlation between cytopathological samples classified according to TBSRTC and their histological finding after specimen examination following surgical procedure. Methods: Cytopathological samples classified according to TBSRTC were correlated with the respective anatomopathological finding after thyroidectomy. There were retrospectively included all cases of thyroidectomy with previous FNA in the same lateral position of the organ that occurred within two years. Results: The 200 cases of thyroid FNA analyzed were distributed in 25 nondiagnostic or unsatisfactory cases (I; 12.5%), 45 benign cases (II; 22.5%), 48 atypia or follicular lesions of undetermined significance [(AUS/FLUS), III; 24%], 23 suspected cases for follicular neoplasia or follicular neoplasias [(SFN/FN), IV; 11.5%], 40 cases suspected for malignancy (V; 20%), and 19 malignant cases (VI; 9.5%). The malignancy rates observed for categories I to VI were 12%, 13.3%, 29.2%, 43.5%, 85%, and 100%, respectively. Conclusion: The prevalence of Bethesda II category was lower than predicted by TBSRTC (60%-70%), as well as Bethesda III was higher than recommended (7%). Nevertheless, the corresponding malignancy rates were within the expected ranges.
DOI: 10.6084/m9.figshare.7591361.v1
title: The new definition of the kilogram in terms of Planck's constant

description: Abstract In 2019, the unity of mass of the International System of Units (SI), the kilogram, will have its definition modified. It will not be anymore the metallic artifact kept in the BIPM building, in the neighborhood of Paris, to be based on Planck's constant (h). What is the need for this change? And how the measurements will be done? These are some of the questions that will be answered at this communication, where we describe the operation of the experiment named Watt Balance used in the new way to realize the unity of mass. Besides that, we will describe how we assembled a Balance for teaching purposes, used in talks about the theme. The topic interests everybody, but in special students that take physics courses in any area.
DOI: 10.6084/m9.figshare.7591364.v1
title: Occurrence of Pesticides and PPCPs in Surface and Drinking Water in Southern Brazil: Data on 4-Year Monitoring

description: This study evaluated the environmental occurrence of fifty-one pesticides, pharmaceuticals and personal care products (PPCPs) in surface and drinking water samples collected in southern Brazil over a 4-year period. The method used involved a stage based on solid-phase extraction, followed by liquid chromatography tandem mass spectrometry. Thirty compounds were detected (22 different pesticides and 8 PPCPs) and at least four compounds were identified in more than 50% of the samples. Atrazine was the most frequently detected pesticide and it was found at concentrations between 5 and 49 ng L-1. From PPCPs, glibenclamide, methylparaben and nimesulide were the most commonly detected in both drinking water and surface water samples. Results showed the extent to which traces of pesticides and PPCPs were present in water samples from this region.
DOI: 10.7284/115579
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise FK140420 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Falkor

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7591355
title: Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report

description: ABSTRACT Takayasu arteritis (TA) is a chronic granulomatous inflammatory condition of unknown cause that involves large vessels - particularly the aorta and its branches - such as the carotid, coronary, pulmonary, and renal arteries. The left subclavian artery is the most frequently involved vessel. Stenosis of the renal artery has been reported in 23-31% of the cases and may result in malignant hypertension, ischemic renal disease, decompensated heart failure, and premature death. Involvement of both renal arteries is uncommon. Early onset anuria and acute kidney injury are rare and have been reported only in a few cases in the literature. This report describes the case of a 15-year-old female with constitutional symptoms evolving for a year, combined with headache, nausea, and vomiting, in addition to frequent visits to emergency services and insufficient clinical examination. The patient worsened significantly six months after the onset of symptoms and developed acute pulmonary edema, oliguria, acute kidney injury, and difficult-to-control hypertension, at which point she was admitted for intensive care and hemodialysis. Initial ultrasound examination showed she had normal kidneys and stenosis-free renal arteries. The patient was still anuric after 30 days of hospitalization. A biopsy was performed and revealed her kidneys were normal. Computed tomography angiography scans of the abdominal aorta presented evidence of occlusion of both renal arteries. The patient met the diagnostic criteria for Takayasu arteritis and had a severe complication rarely described in the literature: stenosis of the two renal arteries during the acute stage of ischemic renal disease.
DOI: 10.6084/m9.figshare.7591355.v1
title: Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report

description: ABSTRACT Takayasu arteritis (TA) is a chronic granulomatous inflammatory condition of unknown cause that involves large vessels - particularly the aorta and its branches - such as the carotid, coronary, pulmonary, and renal arteries. The left subclavian artery is the most frequently involved vessel. Stenosis of the renal artery has been reported in 23-31% of the cases and may result in malignant hypertension, ischemic renal disease, decompensated heart failure, and premature death. Involvement of both renal arteries is uncommon. Early onset anuria and acute kidney injury are rare and have been reported only in a few cases in the literature. This report describes the case of a 15-year-old female with constitutional symptoms evolving for a year, combined with headache, nausea, and vomiting, in addition to frequent visits to emergency services and insufficient clinical examination. The patient worsened significantly six months after the onset of symptoms and developed acute pulmonary edema, oliguria, acute kidney injury, and difficult-to-control hypertension, at which point she was admitted for intensive care and hemodialysis. Initial ultrasound examination showed she had normal kidneys and stenosis-free renal arteries. The patient was still anuric after 30 days of hospitalization. A biopsy was performed and revealed her kidneys were normal. Computed tomography angiography scans of the abdominal aorta presented evidence of occlusion of both renal arteries. The patient met the diagnostic criteria for Takayasu arteritis and had a severe complication rarely described in the literature: stenosis of the two renal arteries during the acute stage of ischemic renal disease.
DOI: 10.6084/m9.figshare.7591358.v1
title: Investigation of correlation between cytological and histological findings in suspected carcinoma of thyroid

description: ABSTRACT Introduction: The thyroid cytopathologic classification based on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) standardized results derived from fine-needle aspiration (FNA). It has facilitated communication among clinicians, seems to reduce the number of unnecessary thyroidectomies and also improves the quality of malignancy detection. Objective: To evaluate the correlation between cytopathological samples classified according to TBSRTC and their histological finding after specimen examination following surgical procedure. Methods: Cytopathological samples classified according to TBSRTC were correlated with the respective anatomopathological finding after thyroidectomy. There were retrospectively included all cases of thyroidectomy with previous FNA in the same lateral position of the organ that occurred within two years. Results: The 200 cases of thyroid FNA analyzed were distributed in 25 nondiagnostic or unsatisfactory cases (I; 12.5%), 45 benign cases (II; 22.5%), 48 atypia or follicular lesions of undetermined significance [(AUS/FLUS), III; 24%], 23 suspected cases for follicular neoplasia or follicular neoplasias [(SFN/FN), IV; 11.5%], 40 cases suspected for malignancy (V; 20%), and 19 malignant cases (VI; 9.5%). The malignancy rates observed for categories I to VI were 12%, 13.3%, 29.2%, 43.5%, 85%, and 100%, respectively. Conclusion: The prevalence of Bethesda II category was lower than predicted by TBSRTC (60%-70%), as well as Bethesda III was higher than recommended (7%). Nevertheless, the corresponding malignancy rates were within the expected ranges.
DOI: 10.6084/m9.figshare.7591349
title: Analysis of Quality and Lifestyle among Medical Students of an Institution in the North of Paraná

description: ABSTRACT The purpose of this research was to evaluate the lifestyle and estimate the prevalence of consumption of alcohol, tobacco and other drugs among medical students of an institution in Maringá, Paraná. It is a cross-sectional, exploratory, descriptive study, with undergraduates from the first to sixth years of medical school. The data collection was carried out from June to August 2017, using a self-administered instrument called the “Fantastic Lifestyle Checklist”, which is composed of 25 objective questions, that consider the individual’s behavior in the last month. The results of the questionnaire are used to determine the association between lifestyle and health. Totalling all the points gives a total score that classifies individuals into one of five categories: “Excellent”, “Very Good”, “Good”, “Fair” and “Needs improvement”. It is desirable for individuals to achieve a “Good” rating. The lower the score, the greater the need for change. The exclusion criteria adopted were: students under 18 years old, and those not present on the day of the data collection. Next, the data were transferred to spreadsheet, then analyzed using descriptive statistics. 576 medical students participated in the research, the majority aged between 21 and 25 years old, female, White, single, had studied at a private high school, and living alone. Regarding the parents’ level of education, the data showed that 73.61% of the fathers and 83.68% of the mothers had studied for 12 or more years. Less than half of the students reported a diagnosis of depression or other chronic mental health condition. Most of the students did not sleep well and did not feel rested. There was a high prevalence of students who are satisfied with their respective jobs or positions. In addition, most reported that they had not smoked in the last year and had never used drugs such as marijuana and cocaine, while 81% reported an average alcohol intake per week of 0 to 7 units. The predominant classification among the students in the Fantastic Lifestyle Questionnaire was “Good”. It is therefore concluded that students should be given guidance on how to adopt a healthier lifestyle while engaged in academic activities.
DOI: 10.6084/m9.figshare.7591352
title: Academic Leagues and Medical Training: An Exploratory Study in a Traditional School of Medicine

description: ABSTRACT The rising number of students leagues in the Escola Paulista de Medicina of the Universidade Federal de São Paulo (EPM–Unifesp) leads to questions about their meaning to students and their role in medical training, as well as concerns about learning distortions, early specialization, social relevance, and insertion in the Brazilian national health system, called the Sistema Único de Saúde (SUS). In order to try and clarify these questions, this qualitative study analyzes the statues of the leagues, and the statements of tutors and students, gathered by means of four focal groups with students and two interviews with the tutors. We found 45 leagues currently running at the EPM–Unifesp, most of them associated with a medical specialty. The main motivators for joining in a league were: the search for practical activities, the desire to gain more experience of a particular specialty, the desire for more knowledge, and the need to be recognized as a responsible adult. Of the leagues studied, few conducted research or university extension activities, focusing on treatment and theoretical classes, supervised by professors, non-teacher physicians, resident doctors, or more senior students. The tutors are in charge of the organizational aspects. The leagues can reproduce graduation models, such as an overburdoning with activities and poor expository classes. Concerning insertion in the SUS, the leagues could be a means of training future SUS professionals. Although students claim that they intend to specialize in the league’s field, the tutors disagree that they lead to early specialization. We consider that while leagues fill gaps in the learning and expectations of the course, they are limited in regards to the impact of their activities on medical training and their social relevance. They can subvert the curricular structure and favor early specialization. We recommend that universities pay closer attention to students leagues, observing their number, selection process, activities, tutors involved and explicit objectives, with the purpose of evaluating their roles in the curriculum and medical training.