cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.23728/b2share.5b077f6e3b664e19bedbb3311af2e8e7
title: Seroepidemiological assessment of the spread of SARS-CoV-2 among 25 and 28 year-old adult women in Finland between March 2020-June 2022

description: Serological surveys of the prevalence of SARS-CoV-2 are instrumental to understanding the course of the COVID-19 epidemic. We evaluate the seroprevalence of SARS-CoV-2 among young adult Finnish females residing in 25 communities all over Finland from 2020 until 2022.
Between 1st March 2020 and 30th June 2022, 3589 blood samples were collected from 3583 women born in 1992-95 when aged 25 or 28 years old attending the follow-up of an ongoing population-based trial of cervical screening strategies. The crude and population standardized SARS-CoV-2 seroprevalence was measured using nucleocapsid (induced by infection) and spike wild-type (WT) protein (induced both by infection and by vaccination) antigens over time and stratified by place of residence (inside or outside the Helsinki metropolitan region).
During 2020 (before vaccinations), spike-WT and nucleocapsid IgG antibodies followed each other closely, at very low levels (&lt;5%). Spike-WT seropositivity increased rapidly concomitant with mass vaccinations in 2021 and reached 96.3% in the 2nd quartile of 2022. Antibodies to nucleocapsid IgG remained relatively infrequent throughput 2020-2021, increasing rapidly in the 1st and 2nd quartiles of 2022 (to 19.7% and 56.6% respectively). The nucleocapsid IgG seropositivity increased more profoundly in participants residing in the Helsinki metropolitan region (4.5%, 8.4% and 43.9% in 2020, 2021 and 2022 respectively) compared to those residing in communities outside the capital region (4.5%, 4.3% and 34.7%).
Low SARS-CoV-2 infection-related seroprevalence during 2020-2021 suggest a comparatively successful infection control. Antibodies to the SARS-CoV-2 WT spike protein became extremely common among young women by the end of 2021, in line with the high uptake of SARS-CoV-2 vaccination. Finally, the rapid increase of seroprevalences to the SARS-CoV-2 nucleocapsid protein during the first and second quartile of 2022, imply a high incidence of infections with SARS-CoV-2 variants able to escape vaccine-induced protection.
DOI: 10.15468/dl.fbdaxn
title: Occurrence Download

description: A dataset containing 52 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Spain",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Bacopa monnieri (L.) Pennell"
 ]
}

 The dataset includes 52 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011510-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6qdr2h
title: Occurrence Download

description: A dataset containing 543171 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Leucanthemum vulgare Lam.)"
 ]
}

 The dataset includes 543171 records from 3014 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011509-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.7284/138281
title: GNSS (Global Navigation Satellite System) data collected during research cruise OCNSF19 using a Furuno GP-90 instrument system onboard the platform RV Oceanus

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.15468/dl.jlnhg4
title: Occurrence Download

description: A dataset containing 12946 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cytisophyllum sessilifolium (L.) O.Lang",
 "Country is France"
 ]
}

 The dataset includes 12946 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071695-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s35kq3
title: Occurrence Download

description: A dataset containing 273 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lebia marginata (Geoffroy, 1785)"
 ]
}

 The dataset includes 273 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004672-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m3wegf
title: Occurrence Download

description: A dataset containing 1342 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Ehretia microphylla Lam.)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1342 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0053564-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5umyge
title: Occurrence Download

description: A dataset containing 240 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Specimen",
 "Country is Colombia",
 "TaxonKey is Kinosternon leucostomum (Duméril, Bibron & Duméril, 1851)"
 ]
}

 The dataset includes 240 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0152344-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.43zwpd
title: Occurrence Download

description: A dataset containing 20195380 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Year 1000-1980",
 "TaxonKey is Aves"
 ]
}

 The dataset includes 20195380 records from 589 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011914-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g7yn5v
title: Occurrence Download

description: A dataset containing 428 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is North America",
 "Country is Mexico",
 "HasCoordinate is true",
 "TaxonKey is Delphinidae",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 428 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0071702-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yad5c8
title: Occurrence Download

description: A dataset containing 196 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "TaxonKey is Streptopelia turtur (Linnaeus, 1758)",
 "Year 2016-2016"
 ]
}

 The dataset includes 196 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0152386-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mhc9w3
title: Occurrence Download

description: A dataset containing 607470 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-32.3877 62.53418,-21.31348 59.37012,-12.34863 34.76074,8.9209 37.9248,22.2649 34.63368,25.26855 39.24316,27.36694 41.45142,36.16699 44.16504,41.96777 48.99902,32.91504 54.00879,29.83887 57.78809,31.68457 71.7627,-17.18262 71.14746,-24.64766 66.91871,-32.3877 62.53418))",
 "HasCoordinate is true",
 "TaxonKey is Cirsium arvense (L.) Scop.",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 607470 records from 850 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024016-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7q4qku
title: Occurrence Download

description: A dataset containing 19593 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fumana ericoides (Cav.) Gand."
 ]
}

 The dataset includes 19593 records from 214 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004524-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.a7v87r
title: Occurrence Download

description: A dataset containing 9438 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fumana laevipes (L.) Spach"
 ]
}

 The dataset includes 9438 records from 156 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004540-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.f5phnf
title: Occurrence Download

description: A dataset containing 1895 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fumana hispidula Loscos & J.Pardo"
 ]
}

 The dataset includes 1895 records from 34 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004535-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8j26n9
title: Occurrence Download

description: A dataset containing 44010 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fumana procumbens (Dunal) Gren. & Godr."
 ]
}

 The dataset includes 44010 records from 626 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004555-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mj7ekn
title: Occurrence Download

description: A dataset containing 24554 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Fumana thymifolia (L.) Spach ex Webb"
 ]
}

 The dataset includes 24554 records from 277 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004558-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t247dc
title: Occurrence Download

description: A dataset containing 607307 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Galium verum L."
 ]
}

 The dataset includes 607307 records from 2469 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004557-241007104925546/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/ifao.archives.161799
title: DENDARA - TEMPLE - Vol.II, pl. LXXXVIII._pv_2004_03782

description: Référence : pv_2004_03782<br />Site : Dendara<br />Secteur : Couloir mystérieux; Temple d'Hathor<br />Type : photographie<br />
DOI: 10.34816/ifao.archives.161800
title: DENDARA - TEMPLE - Vol.II, pl. LXXXVIII._pv_2004_03783

description: Référence : pv_2004_03783<br />Site : Dendara<br />Secteur : Couloir mystérieux; Temple d'Hathor<br />Type : photographie<br />
DOI: 10.15468/dl.77r7m7
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "GadmGid is one of (CHN.15_1, CHN.31_1, CHN.1_1, CHN.24_1)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Impatiens yilingiana X.F.Jin, Shu Z.Yang & L.Qian"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036339-231120084113126/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7a59xy
title: Occurrence Download

description: A dataset containing 171106 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Hedysarum hedysaroides (L.) Schinz & Thell., Helianthemum italicum (L.) Pers., Helianthemum nummularium (L.) Mill., Helianthemum canum (L.) Baumg.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 171106 records from 463 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0242019-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/ifao.archives.161801
title: DENDARA - TEMPLE - Vol.II, pl. LXXXVIII._pv_2004_03784

description: Référence : pv_2004_03784<br />Site : Dendara<br />Secteur : Couloir mystérieux; Temple d'Hathor<br />Type : photographie<br />
DOI: 10.15468/dl.h2yanh
title: Occurrence Download

description: A dataset containing 30480 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Asparagus asparagoides (L.) Druce"
 ]
}

 The dataset includes 30480 records from 170 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012341-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/ifao.archives.161802
title: DENDARA - TEMPLE - Vol.II, pl. LXXXVIII._pv_2004_03703

description: Référence : pv_2004_03703<br />Site : Dendara<br />Secteur : Couloir mystérieux; Temple d'Hathor<br />Type : photographie<br />
DOI: 10.15468/dl.msuemq
title: Occurrence Download

description: A dataset containing 171106 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Hedysarum hedysaroides (L.) Schinz & Thell., Helianthemum italicum (L.) Pers., Helianthemum nummularium (L.) Mill., Helianthemum canum (L.) Baumg.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 171106 records from 463 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0242017-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/ifao.archives.161803
title: DENDARA - TEMPLE - Vol.II, pl. LXXXVIII._pv_2004_03701

description: Référence : pv_2004_03701<br />Site : Dendara<br />Secteur : Couloir mystérieux; Temple d'Hathor<br />Type : photographie<br />
DOI: 10.15468/dl.fxkyxd
title: Occurrence Download

description: A dataset containing 38 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Porphyrospiza alaudina (Kittlitz, 1833)",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 38 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0118978-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34816/ifao.archives.161804
title: DENDARA - TEMPLE - Vol.II, pl. LXXXVIII._pv_2004_03702

description: Référence : pv_2004_03702<br />Site : Dendara<br />Secteur : Couloir mystérieux; Temple d'Hathor<br />Type : photographie<br />
DOI: 10.15468/dl.3hp887
title: Occurrence Download

description: A dataset containing 375788 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Charophyta"
 ]
}

 The dataset includes 375788 records from 952 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012353-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5fzhbm
title: Occurrence Download

description: A dataset containing 36 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Specimen, Human Observation, Material sample, Material citation, Living Specimen, Machine Observation)",
 "Country is one of (Pakistan, China)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is one of (Ursus arctos isabellinus, Panthera uncia)",
 "Year 2000-2025"
 ]
}

 The dataset includes 36 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011672-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3487h6
title: Occurrence Download

description: A dataset containing 57596 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Geoglossomycetes"
 ]
}

 The dataset includes 57596 records from 426 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011638-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5tkcru
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry MULTIPOLYGON(((13.19649 41.22494,13.72972 41.23206,13.72423 41.51365,13.1887 41.50646,13.19649 41.22494)))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Gliridae",
 "Year 1990-2025"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011673-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25824/redu/fzrrkc
title: NMR applied to the metabolomics of soybean cultivated in the absence and presence of silver nanoparticles

description: The dataset deposited here compiles all files generated during the experiment that investigated the effects of silver nanoparticles (AgNPs) and silver nitrate (AgNO₃) on the metabolism of transgenic soybean plants (RR and Intacta genotypes). The collection integrates different types of analytical data used for chemical characterization, metabolic profiling, and multivariate statistical interpretation. Purpose: The purpose of this dataset is to make available, in an organized and reproducible manner, all raw and processed files used in the metabolomics analyses of the study. These files allow replication of the statistical analyses, validation of the results, and future reprocessing using new computational approaches. Nature of the data: The data include: ¹H NMR spectra (zipped folders containing spectra from leaf, stem, and root samples), used for metabolite identification and relative quantification. LC–MS spreadsheets (negative mode) containing peak lists, intensities, and m/z values for leaf, stem, and root samples. Processed MetaboAnalyst files, including normalized tables, transformed data, and working matrices used for multivariate statistical analyses. Bucketed tables (AMIX) corresponding to NMR data employed in PCA and other chemometric evaluations. Spreadsheets of relative signal integration, generated after NMR spectral processing. Scope of the dataset: The dataset covers three plant tissues (leaf, stem, and root), enabling the assessment of metabolic differences between genotypes and treatments. It includes raw files as well as analysis-ready matrices, supporting studies in toxicity, ecophysiology, metabolomics, agricultural nanotechnology, and the complete reproducibility of the project’s findings.
DOI: 10.15468/dl.huujwm
title: Occurrence Download

description: A dataset listing the 1363 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "DatasetKey is EOD – eBird Observation Dataset"
 ]
}

 The dataset's 1363 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011661-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4wfavm
title: Occurrence Download

description: A dataset containing 155 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Annotated Checklist of Tingidae (Hemiptera: Heteroptera) in Turkey with new records for the faunas of Europe and Turkish Thrace"
 ]
}

 The dataset includes 155 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011677-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.4121/37b88a57-230e-4b04-ba9f-b1fb229181c7
title: Computational code underlying the publication “Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe”

description: Computational code to simulate the crosstalk between Bmp9 and Notch signaling in endothelial cells (and pericytes) within in vitro experiments or during sprouting angiogenesis. The objective of the research was to investigate the role that Bmp9-mediated upregulation of Lunatic Fringe expression plays in modulating the activity of Notch in cell culture and angiogenesis experiments. The results of the computational simulations were validated via in vitro and in vivo experiments.