cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23751788
title: Additional file 3 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 3: Table S2. Associated Genes.
DOI: 10.6084/m9.figshare.6455858.v1
title: Multivariate analysis for forensic characterization, discrimination, and classification of marker pen inks

description: The multivariate analysis methods have recently gained high popularity within the field of forensic sciences because of their high accuracy and precision. The accurate and unbiased results are the preliminary need for a forensic investigation. The aim of the present work is to examine the marker pen inks which are widely used in various places like documentation in parcels, for photograph attestation, and also as a study material in the classroom. This research is focused on the three important aspects; first is to characterize the marker inks, second, to discriminate permanent marker and whiteboard marker inks using destructive (extracting of ink samples from paper substrate) and nondestructive (without ink extraction) techniques of ultraviolet–visible absorbance combined with peak identification examination as well as chemometric methods, and the third is to build a classification model for permanent and whiteboard marker inks. It is concluded that the chemometric method, that is, principal component analysis provides better discrimination power as compared to visual examination. However, destructive and nondestructive approaches give almost similar discriminating power. The classification model developed using linear discriminant analysis provides 87.5% of correct classification of marker ink samples. The method can further be used to formulate a statistical model for the determination of class/group of the other forensic exhibits.
DOI: 10.6084/m9.figshare.23751797.v1
title: Additional file 6 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 6: Table S5. SNPs Per GWAS.
DOI: 10.6084/m9.figshare.5931661.v1
title: Design and Analysis of a Novel Spacecraft for Mitigating Global Warming

description: ABSTRACT: A device called Huge Space Shield (HSS) has been put forward for mitigating global warming. This is a space tethers system, which use cables to connect a shielding surface and a mechanism control. In this study, orbital analysis was carried out to choose the best orbit for getting the best effect. Simulation studies were employed to understand the HSS at the beginning of entering the orbit, which were based on completely and semi-simplified model. Therefore, the force analysis gives rise to the system would not fail in the period of running on the orbit. All the results show that the HSS is stable at launch and operation, which can help ease global warming.
DOI: 10.6084/m9.figshare.7504106
title: Additional file 6: of Comparative transcriptomics identifies patterns of selection in roses

description: Table S5. List of the Rosaceae-common single-copy transcripts. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.23751796.v1
title: Additional file 4 of The determination of peanut (Arachis hypogaea L.) pod-sizes during the rapid-growth stage by phytohormones

description: Additional file 4: Table S2. Logistic growth function.
DOI: 10.6084/m9.figshare.23751800.v1
title: Additional file 7 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 7: Table S6. Result SNEEP Per GWAS.
DOI: 10.6084/m9.figshare.7504127
title: Additional file 1: of Choice of fluids in critically ill patients

description: Output of the systematic search. Description of data: Excel table reporting the output of the systematic search (XLSX 485 kb)
DOI: 10.6084/m9.figshare.14320471
title: Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish

description: Abstract Coronary heart disease (CHD) is a leading cause of death worldwide, and angiogenesis plays important roles in CHD. Thus, in the present study, the angiogenic efficacy of four common cardiovascular medicines (aspirin, pravastatin, metoprolol and isosorbide mononitrate (ISMN)) was determined by the number and length of zebrafish intersegmental vessels (ISVs) after immersing zebrafish embryos in different medicines. Results showed that ISMN significantly increased the length and number of ISVs. ISMN is a long-acting nitrate ester drug. It has been used as a vasodilator to dilate arteries and veins to reduce the cardiac preload and postload. However, the effect of ISMN on angiogenesis remains unclear. Thus, by in vitro experiments, the angiogenic mechanism of ISMN was evaluated through detecting the viability and proliferation of human umbilical vein endothelial cells (HUVECs) and the expression of angiogenesis-related genes and miRNAs. Results indicated that ISMN could increase the viability and proliferation of HUVECs by decreasing apoptosis, and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Furthermore, the expressions of miR-126, miR-130a and miR-210 were also regulated in ISMN-treated HUVECs. In conclusion, ISMN could promote angiogenesis in zebrafish embryos and HUVECs, implying ISMN may be a potential therapeutic in treating angiogenesis-related diseases.
DOI: 10.6084/m9.figshare.16941032.v1
title: Abdominal obesity increases the risk of reflux esophagitis: a systematic review and meta-analysis

description: The association between abdominal obesity and reflux esophagitis (RE) has been extensively evaluated, but the current findings are mixed and more convincing epidemiological evidence urgently needs to be established. To thoroughly explore this relationship, we summarized the latest studies, performed an updated meta-analysis, and examined the dose–response relationship. We performed a systematic search of PubMed, Web of Science, and Embase up to 28 March 2021, using prespecified terms to identify studies investigating the association between abdominal obesity and RE. Odds ratios (ORs) with 95% confidence intervals (CIs), mean differences (MDs) or standardized mean differences (SMDs) with 95% CIs were taken as effect-size estimates. Forty-two observational studies, including 11 cohort studies, were meta-analyzed. Overall, a statistically significant association was observed between abdominal obesity and RE, by both the pooled OR (adjusted OR = 1.51, 95% CI: 1.37–1.66, <i>p</i> &lt; .001) and the pooled SMD (SMD = 0.36, 95% CI: 0.30–0.42, <i>p</i> &lt; .001). Moreover, this significant relationship persisted with subgroup stratification. In subgroup analyses, we found that study design, abdominal obesity measurement, adjustment for covariates and sex were possible sources of between-study heterogeneity. For the dose–response analyses, the risk of RE increased with the degree of abdominal obesity, and the increasing trend accelerated when waist circumference (WC) reached 87.0 cm. This meta-analysis indicated a significant association between abdominal obesity and RE, and the risk of RE increased with abdominal obesity especially when the WC was over 87.0 cm.
DOI: 10.6084/m9.figshare.23751802
title: Additional file 6 of The determination of peanut (Arachis hypogaea L.) pod-sizes during the rapid-growth stage by phytohormones

description: Additional file 6: Table S4. Enrichment analysis of overlapping DEGs.
DOI: 10.6084/m9.figshare.14320485.v1
title: A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs

description: Abstract Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the two major subtypes of non–small-cell lung cancer (NSCLC). This study aimed to compare mRNA and circRNA expression patterns between LUSC and LUAD. Cancer tissues from 8 LUSC patients and 12 LUAD patients were collected to obtain mRNA and circRNA expression profiles. The differentially expressed mRNAs (DEmRNAs) and circRNAs (DE-circRNAs) between LUSC and LUAD were screened. Afterwards, miRNA–DEcircRNA pairs and miRNA–DEmRNA pairs were predicted to construct a competing endogenous RNAs (ceRNAs) network, followed by functional enrichment analysis and survival analysis. In total, 635 DEmRNAs and 245 DEcircRNAs were obtained. The ceRNA analysis revealed that genes, such as EPHA2, EPHA7, NTRK2, CDK6, hsa_circ_027570, hsa_circ_006089, and hsa-circ_035997, had distinct expression patterns between LUSC and LUAD. Also, functional enrichment analysis indicated that DEmRNAs were mainly enriched in ERK1 and ERK2 cascade. Survival analyses suggested that STXBP1 and PMEPA1 were associated the prognosis of with both LUAD and LUSC, whereas EPHA2 and CDK6 might serve as prognostic factors for LUSC and LUAD, respectively. In conclusion, genes such as EPHA2, EPHA7, NTRK2, and CDK6 had different patterns in the two major histological subtypes of NSCLC. Notably, EPHA2 and CDK6 might be considered as potential therapeutic targets for LUSC and LUAD, respectively.
DOI: 10.6084/m9.figshare.23751785.v1
title: Additional file 2 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 2: Table S1. Disease Enrichment Protein Coding.
DOI: 10.6084/m9.figshare.23751794
title: Additional file 5 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 5: Table S4. Tested Noncoding RNAs.
DOI: 10.6084/m9.figshare.14320485
title: A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs

description: Abstract Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the two major subtypes of non–small-cell lung cancer (NSCLC). This study aimed to compare mRNA and circRNA expression patterns between LUSC and LUAD. Cancer tissues from 8 LUSC patients and 12 LUAD patients were collected to obtain mRNA and circRNA expression profiles. The differentially expressed mRNAs (DEmRNAs) and circRNAs (DE-circRNAs) between LUSC and LUAD were screened. Afterwards, miRNA–DEcircRNA pairs and miRNA–DEmRNA pairs were predicted to construct a competing endogenous RNAs (ceRNAs) network, followed by functional enrichment analysis and survival analysis. In total, 635 DEmRNAs and 245 DEcircRNAs were obtained. The ceRNA analysis revealed that genes, such as EPHA2, EPHA7, NTRK2, CDK6, hsa_circ_027570, hsa_circ_006089, and hsa-circ_035997, had distinct expression patterns between LUSC and LUAD. Also, functional enrichment analysis indicated that DEmRNAs were mainly enriched in ERK1 and ERK2 cascade. Survival analyses suggested that STXBP1 and PMEPA1 were associated the prognosis of with both LUAD and LUSC, whereas EPHA2 and CDK6 might serve as prognostic factors for LUSC and LUAD, respectively. In conclusion, genes such as EPHA2, EPHA7, NTRK2, and CDK6 had different patterns in the two major histological subtypes of NSCLC. Notably, EPHA2 and CDK6 might be considered as potential therapeutic targets for LUSC and LUAD, respectively.
DOI: 10.6084/m9.figshare.14320491
title: Overexpression of miR-451a in sepsis and septic shock patients is involved in the regulation of sepsis-associated cardiac dysfunction and inflammation

description: Abstract The purpose of this study was to investigate the expression and clinical value of microRNA-451a (miR-451a) in septic patients and analyze its effect on sepsis-associated cardiac dysfunction and inflammation response. A rat model of sepsis was constructed by cecal ligation and puncture. The expression of miR-451a was measured by quantitative real-time PCR. Receiver operating characteristic (ROC) analysis was used to assess the diagnostic value of serum miR-451a. The cardiac function and inflammatory responses in septic rats were measured to explore the functional role of miR-451a. Serum expression of miR-451a was increased in septic patients compared with healthy controls, and had the ability to distinguish septic patients from healthy volunteers with a sensitivity and specificity of 87.8% and 81.5%, respectively. Elevated serum miR-451a was associated with sepsis severity, as evidenced by the increased expression of miR-451a in septic shock patients and its correlation with key clinical indicators. Significantly upregulated expression of miR-451a was found in septic patients with cardiac dysfunction, and the knockdown of miR-451a in sepsis rats improved cardiac function and inhibited inflammatory responses. All the data revealed that serum miR-451a serves as a candidate diagnostic biomarker of sepsis and a potential parameter to indicate disease severity. The reduction of miR-451a may mitigate sepsis-induced cardiac dysfunction and inflammatory responses.
DOI: 10.6084/m9.figshare.23751800
title: Additional file 7 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 7: Table S6. Result SNEEP Per GWAS.
DOI: 10.6084/m9.figshare.6455858
title: Multivariate analysis for forensic characterization, discrimination, and classification of marker pen inks

description: The multivariate analysis methods have recently gained high popularity within the field of forensic sciences because of their high accuracy and precision. The accurate and unbiased results are the preliminary need for a forensic investigation. The aim of the present work is to examine the marker pen inks which are widely used in various places like documentation in parcels, for photograph attestation, and also as a study material in the classroom. This research is focused on the three important aspects; first is to characterize the marker inks, second, to discriminate permanent marker and whiteboard marker inks using destructive (extracting of ink samples from paper substrate) and nondestructive (without ink extraction) techniques of ultraviolet–visible absorbance combined with peak identification examination as well as chemometric methods, and the third is to build a classification model for permanent and whiteboard marker inks. It is concluded that the chemometric method, that is, principal component analysis provides better discrimination power as compared to visual examination. However, destructive and nondestructive approaches give almost similar discriminating power. The classification model developed using linear discriminant analysis provides 87.5% of correct classification of marker ink samples. The method can further be used to formulate a statistical model for the determination of class/group of the other forensic exhibits.
DOI: 10.6084/m9.figshare.6456218
title: Diversity of nitrate, oxalate, vitamin C and carotenoid contents in different spinach accessions and their correlation with various morphological traits

description: Spinach (<i>Spinacia oleracea</i> L.) accumulates high amounts of carotenoids, vitamin C, nitrate and oxalate. Breeding to reduce nitrate and oxalate levels and increase vitamin C and carotenoid levels is a major target in spinach nutritional quality improvement. Here we investigate natural variations in the levels of nitrate, oxalate, vitamin C, and total carotenoid in 98 spinach accessions, and correlations among these four nutritional components and 12 important morphological traits. Our results showed that the concentrations of nitrate, oxalate, vitamin C, and total carotenoid ranged from 0.21–3.83, 2.38–34.72, 0.51–1.30, and 0.18–0.58 mg g<sup>−1</sup> fresh weight (FW), respectively. Moderate positive correlations were observed between the levels of oxalate and vitamin C, and between vitamin C and total carotenoid, whereas the levels of nitrate were correlated weakly and negatively with those of vitamin C and total carotenoid. The nitrate contents of crinkle-leaf accessions were significant higher than those of smooth-leaf accessions, and the smooth-leaf accessions had significantly higher concentrations of oxalate and vitamin C than crinkle-leaf accessions. Furthermore, hierarchical clustering analysis identified eight spinach accessions that could be served as starting materials for breeding new spinach cultivars with increased levels of vitamin C and carotenoids and simultaneously decreased accumulation of nitrate and oxalate.
DOI: 10.6084/m9.figshare.14320503.v1
title: Characterization of three new mitochondrial genomes of Coraciiformes (Megaceryle lugubris, Alcedo atthis, Halcyon smyrnensis) and insights into their phylogenetics

description: Abstract Coraciiformes contains more than 200 species with great differences on external morphology and life-style. The evolutionary relationships within Coraciiformes and the phylogenetic placement of Coraciiformes in Aves are still questioned. Mitochondrial genome (mitogenome) sequences are popular markers in molecular phylogenetic studies of birds. This study presented the genome characteristics of three new mitogenomes in Coraciiformes and explored the phylogenetic relationships among Coraciiformes and other five related orders with mitogenome data of 30 species. The sizes of three mitogenomes were 17,383 bp (Alcedo atthis), 17,892 bp (Halcyon smyrnensis) and 17,223 bp (Megaceryle lugubris). Each mitogenome contained one control region and 37 genes that were common in vertebrate mitogenomes. The organization of three mitogenomes was identical to the putative ancestral gene order in Aves. Among 13 available Coraciiform mitogenomes, 12 protein coding genes showed indications of negative selection, while the MT-ND6 presented sign of positive selection or relaxed purifying selection. The phylogenetic results supported that Upupidae and Bucerotidae should be separated from Coraciiformes, and that Coraciiformes is more closely related to Piciformes than to Strigiformes, Trogoniformes and Cuculiformes. Our study provide valuable data for further phylogenetic investigation of Coraciiformes.
DOI: 10.6084/m9.figshare.23751803
title: Additional file 8 of CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

description: Additional file 8: Table S7. Co-expressed PCG.
DOI: 10.6084/m9.figshare.23751802.v1
title: Additional file 6 of The determination of peanut (Arachis hypogaea L.) pod-sizes during the rapid-growth stage by phytohormones

description: Additional file 6: Table S4. Enrichment analysis of overlapping DEGs.
DOI: 10.6084/m9.figshare.13271580
title: Transcriptome-wide identification of WRKY family genes and their expression profiling toward salicylic acid in Camellia japonica

description: The ornamental plant <i>Camellia japonica</i> is widely distributed worldwide and is susceptible to various environmental stresses. The WRKY transcription factor (TF) is an important node of plant tolerance. However, WRKY TFs from <i>C. japonica</i> have not been reported yet. In this study, 48 <i>CjWRKYs</i>, namely, <i>CjWRKY1</i> to <i>CjWRKY48</i>, were identified. Protein structure analysis revealed that CjWRKY proteins contain a highly conserved motif (WRKYGQK) and two variant motifs (WRKYGKK and WRKYGRK). Phylogenetic analysis indicated that the 48 CjWRKYs can be divided into three groups, which are further classified into six subgroups, namely, I-C, II-a, II-b, II-c, II-e, and III, which contain 10, 6, 8, 13, 7, and 4 members, respectively. The expression patterns of 15 <i>CjWRKYs</i> under salicylic acid (SA) treatment were investigated by real-time quantitative PCR (qRT-PCR). Results showed that the 15 <i>CjWRKYs</i> could be induced by SA treatment. This study is the first to screen <i>CjWRKYs</i> and identify the expression profile of <i>CjWRKYs</i> under SA treatment and provides a theoretical basis for analyzing the function of <i>CjWRKY</i> genes to SA stress tolerance in <i>C. japonica</i>.
DOI: 10.6084/m9.figshare.13271580.v1
title: Transcriptome-wide identification of WRKY family genes and their expression profiling toward salicylic acid in Camellia japonica

description: The ornamental plant <i>Camellia japonica</i> is widely distributed worldwide and is susceptible to various environmental stresses. The WRKY transcription factor (TF) is an important node of plant tolerance. However, WRKY TFs from <i>C. japonica</i> have not been reported yet. In this study, 48 <i>CjWRKYs</i>, namely, <i>CjWRKY1</i> to <i>CjWRKY48</i>, were identified. Protein structure analysis revealed that CjWRKY proteins contain a highly conserved motif (WRKYGQK) and two variant motifs (WRKYGKK and WRKYGRK). Phylogenetic analysis indicated that the 48 CjWRKYs can be divided into three groups, which are further classified into six subgroups, namely, I-C, II-a, II-b, II-c, II-e, and III, which contain 10, 6, 8, 13, 7, and 4 members, respectively. The expression patterns of 15 <i>CjWRKYs</i> under salicylic acid (SA) treatment were investigated by real-time quantitative PCR (qRT-PCR). Results showed that the 15 <i>CjWRKYs</i> could be induced by SA treatment. This study is the first to screen <i>CjWRKYs</i> and identify the expression profile of <i>CjWRKYs</i> under SA treatment and provides a theoretical basis for analyzing the function of <i>CjWRKY</i> genes to SA stress tolerance in <i>C. japonica</i>.
DOI: 10.6084/m9.figshare.7504094.v1
title: Additional file 4: of Comparative transcriptomics identifies patterns of selection in roses

description: Table S3. KEGG and GO enrichment analysis for coreset1 transcripts. Note that each transcript could be mapped to several GO terms and KEGG categories. (XLSX 306 kb)
DOI: 10.6084/m9.figshare.7504106.v1
title: Additional file 6: of Comparative transcriptomics identifies patterns of selection in roses

description: Table S5. List of the Rosaceae-common single-copy transcripts. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.7504121.v1
title: Additional file 9: of Comparative transcriptomics identifies patterns of selection in roses

description: Table S7. GO annotation for the 409 positively selected genes. (XLSX 22 kb)
DOI: 10.6084/m9.figshare.6979883
title: Amino acid alignment of spore killer resistance gene (rsk) in Neurospora.

description: The fungus <i>Neurospora</i> intermedia harbours two meiotic drive elements known as <i>Spore killer 2</i> (<i>Sk-2</i>) and <i>Spore killer 3</i> (<i>Sk-3</i>). Different alleles at the <i>rsk</i> locus confers resistance against these.<br>This dataset contains a trimmed amino acid alignment of the <i>rsk</i> gene from 98 strains of <i>Neurospora</i>.<br>This dataset was deposited as part of the paper Svedberg et al. (In press) "Convergent evolution of complex 
genomic rearrangements in two fungal meiotic drive elements". See paper for further details: https://www.nature.com/articles/s41467-018-06562-x 
(DOI:10.1038/s41467-018-06562-x)<br>For more details on <i>rsk</i>, see: Hammond et al. (2012). Molecular dissection of Neurospora Spore killer meiotic drive elements. Proc. Natl. Acad. Sci. U.S.A. <i>109</i>, 12093–12098.
DOI: 10.25934/pr00004699.1
title: Available IPD datapackage for study 'A Placebo-Controlled, Double-Blinded, Randomized Clinical Trial of Anti-TNF Chimeric Monoclonal Antibody (cA2) in Patients With Active Rheumatoid Arthritis Despite Methotrexate Treatment'

description: The purpose of this study is to evaluate the safety and effectiveness of infliximab (an anti-TNF chimeric monoclonal antibody [cA2]) in patients with active Rheumatoid Arthritis, despite methotrexate treatment.
DOI: 10.6084/m9.figshare.16417432.v1
title: Additional file 2 of Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

description: Additional file 2: Table S1. The profiles of the ecDNAs.
DOI: 10.15468/dl.zjdg7w
title: Occurrence Download

description: A dataset containing 76 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Austria",
 "TaxonKey is Sempervivum pittonii Schott, Nyman & Kotschy"
 ]
}

 The dataset includes 76 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008436-181003121212138/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.