cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.kt5nq/3
title: TimeSeries_GerminationCohort_ArrayGenotype

description: Raw microarray genotyping data derived by the Agilent feature extraction software, with built-in rank invariant normalization. Data from the manufacturer-supplied quality-control probes are not included. Cohorts (early, medium, late, and all germinants) are genotyped in two biologcal replicates (rep1 and rep2), and with dye-swap hybridization replicates (Cy3 and Cy5).
DOI: 10.6084/m9.figshare.7878827
title: Additional file 8: of Genome-wide analysis of three histone marks and gene expression in Paulownia fortunei with phytoplasma infection

description: Table S6. List of genes involved in phenylpropanoid biosynthesis from ChIP-Seq analysis (XLSX 20 kb)
DOI: 10.6084/m9.figshare.21510276
title: Additional file 3 of Functional structure analysis and genome-wide identification of CNX gene family in cotton

description: Additional file 3. Table S3: Primer pairs required for the qRT-PCR.
DOI: 10.6084/m9.figshare.21510276.v1
title: Additional file 3 of Functional structure analysis and genome-wide identification of CNX gene family in cotton

description: Additional file 3. Table S3: Primer pairs required for the qRT-PCR.
DOI: 10.6084/m9.figshare.7878827.v1
title: Additional file 8: of Genome-wide analysis of three histone marks and gene expression in Paulownia fortunei with phytoplasma infection

description: Table S6. List of genes involved in phenylpropanoid biosynthesis from ChIP-Seq analysis (XLSX 20 kb)
DOI: 10.6084/m9.figshare.21510309
title: Additional file 2 of Analysis of risk factors related to extremely and very preterm birth: a retrospective study

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.21510306
title: Additional file 1 of Analysis of risk factors related to extremely and very preterm birth: a retrospective study

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21510306.v1
title: Additional file 1 of Analysis of risk factors related to extremely and very preterm birth: a retrospective study

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21510309.v1
title: Additional file 2 of Analysis of risk factors related to extremely and very preterm birth: a retrospective study

description: Supplementary Material 2
DOI: 10.6084/m9.figshare.7878851
title: Additional file 1: of Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu

description: Figure S1. Particle size/relative intensity 3D plot of exosomes by using nanosight technology, relative to Fig. 2C. Figure S2. Image of primary HUVEC, relative to Fig. 2D. Figure S3. Representative photos of the HUVEC uptake of PKH26-labeled exosomes (10 μg/ml, 5 μg/ml, 2.5 μg/ml) at 3 h, 6 h, 12 h, and 21 h. Bar = 10 μm, relative to Fig. 2E. (ZIP 2100 KB)
DOI: 10.6084/m9.figshare.7878851.v1
title: Additional file 1: of Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu

description: Figure S1. Particle size/relative intensity 3D plot of exosomes by using nanosight technology, relative to Fig. 2C. Figure S2. Image of primary HUVEC, relative to Fig. 2D. Figure S3. Representative photos of the HUVEC uptake of PKH26-labeled exosomes (10 μg/ml, 5 μg/ml, 2.5 μg/ml) at 3 h, 6 h, 12 h, and 21 h. Bar = 10 μm, relative to Fig. 2E. (ZIP 2100 KB)
DOI: 10.6084/m9.figshare.21510373
title: Additional file 1 of Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease

description: Additional file 1. RoB-2 evaluation.
DOI: 10.6084/m9.figshare.21510373.v1
title: Additional file 1 of Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease

description: Additional file 1. RoB-2 evaluation.
DOI: 10.6084/m9.figshare.21510352.v1
title: Additional file 4 of Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

description: Additional file 4: Table S2. The names of the 8 cuproptosis-related lncRNAsin the model.
DOI: 10.6084/m9.figshare.21510376
title: Additional file 2 of Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease

description: Additional file 2. Publication bias.
DOI: 10.6084/m9.figshare.21510352
title: Additional file 4 of Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

description: Additional file 4: Table S2. The names of the 8 cuproptosis-related lncRNAsin the model.
DOI: 10.6084/m9.figshare.21510355
title: Additional file 5 of Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

description: Additional file 5: Table S3. Theclinical features between the entire set, training set and the testing set inthe risk model.
DOI: 10.6084/m9.figshare.21510355.v1
title: Additional file 5 of Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

description: Additional file 5: Table S3. Theclinical features between the entire set, training set and the testing set inthe risk model.
DOI: 10.6084/m9.figshare.21510376.v1
title: Additional file 2 of Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease

description: Additional file 2. Publication bias.
DOI: 10.6084/m9.figshare.19413225
title: Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation

description: Forkhead box O1 (FoxO1) is a critical molecule in modulating cell growth, differentiation and metabolism, acting as a vital transcription factor. This study explored the role of FoxO1 in chronic constriction injury (CCI)-induced neuropathic pain (NP). Microglial and astrocyte activation was achieved with lipopolysaccharide (LPS, 100 ng/mL) to establish an <i>in-vitro</i> NP model. Morphological alterations in LPS-induced microglia and astrocytes were assayed by light microscopy. The levels of inflammatory cytokines and proteins in microglia and astrocytes were gauged by enzyme-linked immunosorbent assay (ELISA), and Western blot (WB). The CCI-induced NP rat model was constructed for investigating the FoxO1-AQP5 axis in NP. LPS markedly expanded the expression of inflammatory factors and boosted the expression of FoxO1 and AQP5 in microglia and astrocytes. Inhibition of FoxO1 or AQP5 dramatically decreased the LPS-induced inflammation in microglia and astrocytes. <i>In vivo</i>, CCI exacerbated the inflammatory response and NP symptoms and substantially raised the contents of FoxO1 and AQP5 in rats’ spinal cord tissues. Intrathecal administration of the Sirt1 agonist Resveratrol abated CCI-induced activation of FoxO1 and AQP5, abrogated CCI-induced mechanical hyperalgesia and thermal hyperalgesia, depressed microglial and astrocyte activation, and declined the generation of pro-inflammatory mediators in spinal cord tissues. Mechanistically, blocking the FoxO1-AQP5 pathway inactivated the ERK and p38 MAPK pathways. Suppressing the FoxO1-AQP5 axis alleviated CCI-induced NP and inflammatory responses by modulating the ERK and p38 MAPK signaling pathways.
DOI: 10.6084/m9.figshare.19413225.v1
title: Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation

description: Forkhead box O1 (FoxO1) is a critical molecule in modulating cell growth, differentiation and metabolism, acting as a vital transcription factor. This study explored the role of FoxO1 in chronic constriction injury (CCI)-induced neuropathic pain (NP). Microglial and astrocyte activation was achieved with lipopolysaccharide (LPS, 100 ng/mL) to establish an <i>in-vitro</i> NP model. Morphological alterations in LPS-induced microglia and astrocytes were assayed by light microscopy. The levels of inflammatory cytokines and proteins in microglia and astrocytes were gauged by enzyme-linked immunosorbent assay (ELISA), and Western blot (WB). The CCI-induced NP rat model was constructed for investigating the FoxO1-AQP5 axis in NP. LPS markedly expanded the expression of inflammatory factors and boosted the expression of FoxO1 and AQP5 in microglia and astrocytes. Inhibition of FoxO1 or AQP5 dramatically decreased the LPS-induced inflammation in microglia and astrocytes. <i>In vivo</i>, CCI exacerbated the inflammatory response and NP symptoms and substantially raised the contents of FoxO1 and AQP5 in rats’ spinal cord tissues. Intrathecal administration of the Sirt1 agonist Resveratrol abated CCI-induced activation of FoxO1 and AQP5, abrogated CCI-induced mechanical hyperalgesia and thermal hyperalgesia, depressed microglial and astrocyte activation, and declined the generation of pro-inflammatory mediators in spinal cord tissues. Mechanistically, blocking the FoxO1-AQP5 pathway inactivated the ERK and p38 MAPK pathways. Suppressing the FoxO1-AQP5 axis alleviated CCI-induced NP and inflammatory responses by modulating the ERK and p38 MAPK signaling pathways.
DOI: 10.6084/m9.figshare.21510349
title: Additional file 3 of Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

description: Additional file 3: Table S1. Thegene names of the 19 cuproptosis-related genes.
DOI: 10.6084/m9.figshare.21510349.v1
title: Additional file 3 of Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

description: Additional file 3: Table S1. Thegene names of the 19 cuproptosis-related genes.
DOI: 10.6084/m9.figshare.24131850
title: The presence of baseline HBsAb-Specific B cells can predict HBsAg or HBeAg seroconversion of chronic hepatitis B on treatment

description: Indices for predicting HBsAg or HBeAg seroconversion in patients with chronic hepatitis B virus (HBV) infection during antiviral therapy remain elusive. We aimed to investigate if the presence of HBsAb-specific B cells at baseline can predict HBsAg or HBeAg seroconversion. In this study, 134 treatment-naive patients with chronic HBV were enrolled. A baseline HBsAb-specific B cell ELISpot assay was performed for all the patients that enrolled. Serum samples were collected at 12, 24, and 48 weeks for patients treated with Peg-IFN-α, or at 1 year, 3 years, and 5 years for patients treated with NAs. Laboratory testing of HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HBV DNA, ALT, and AST was done. We observed a significantly lower frequency of HBsAb-specific B cells in patients with chronic HBV than in healthy individuals . In the Peg-IFN-α-treated group, 41.2% of patients with baseline HBsAb-specific B cells achieved HBsAg seroconversion, while only 13.6% of patients without baseline HBsAb-specific B cells achieved HBsAg seroconversion (<i>p</i> = 0.006). By logistic regression analysis, patients with baseline HBsAb-specific B cells and HBsAg ≤ 1500 had higher HBsAg clearance at the end of treatment (<i>p</i> &lt; 0.05). In the NA-treated group, 58.3% of patients with baseline HBsAb-specific B cells achieved HBeAg seroconversion, whereas only 30.0% of patients without baseline HBsAb-specific B cells achieved HBeAg seroconversion (<i>p</i> = 0.114). Our result revealed that baseline HBsAb-specific B cells by ELISpot assay might be a valuable predictive biomarker of HBsAg or HBeAg seroconversion in patients with chronic HBV on treatment.
DOI: 10.6084/m9.figshare.24131850.v2
title: The presence of baseline HBsAb-Specific B cells can predict HBsAg or HBeAg seroconversion of chronic hepatitis B on treatment

description: Indices for predicting HBsAg or HBeAg seroconversion in patients with chronic hepatitis B virus (HBV) infection during antiviral therapy remain elusive. We aimed to investigate if the presence of HBsAb-specific B cells at baseline can predict HBsAg or HBeAg seroconversion. In this study, 134 treatment-naive patients with chronic HBV were enrolled. A baseline HBsAb-specific B cell ELISpot assay was performed for all the patients that enrolled. Serum samples were collected at 12, 24, and 48 weeks for patients treated with Peg-IFN-α, or at 1 year, 3 years, and 5 years for patients treated with NAs. Laboratory testing of HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HBV DNA, ALT, and AST was done. We observed a significantly lower frequency of HBsAb-specific B cells in patients with chronic HBV than in healthy individuals . In the Peg-IFN-α-treated group, 41.2% of patients with baseline HBsAb-specific B cells achieved HBsAg seroconversion, while only 13.6% of patients without baseline HBsAb-specific B cells achieved HBsAg seroconversion (<i>p</i> = 0.006). By logistic regression analysis, patients with baseline HBsAb-specific B cells and HBsAg ≤ 1500 had higher HBsAg clearance at the end of treatment (<i>p</i> &lt; 0.05). In the NA-treated group, 58.3% of patients with baseline HBsAb-specific B cells achieved HBeAg seroconversion, whereas only 30.0% of patients without baseline HBsAb-specific B cells achieved HBeAg seroconversion (<i>p</i> = 0.114). Our result revealed that baseline HBsAb-specific B cells by ELISpot assay might be a valuable predictive biomarker of HBsAg or HBeAg seroconversion in patients with chronic HBV on treatment.
DOI: 10.6084/m9.figshare.21510391
title: Additional file 1 of Direct anterior versus posteriorlateral approachs for clinical outcomes after total hip arthroplasty in the treatment of severe DDH

description: Additional file 1 .
DOI: 10.6084/m9.figshare.21510391.v1
title: Additional file 1 of Direct anterior versus posteriorlateral approachs for clinical outcomes after total hip arthroplasty in the treatment of severe DDH

description: Additional file 1 .
DOI: 10.6084/m9.figshare.21510511
title: Additional file 12 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 12: Table S7. Functional enrichment of genes harboring at least 15 DMCs.
DOI: 10.6084/m9.figshare.21510517.v1
title: Additional file 14 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 14: Table S9. The list of differentially expressed (DE) genes and their functional enrichment.
DOI: 10.6084/m9.figshare.21510529
title: Additional file 18 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 18: Table S13. The correlation between discriminant candidate biomarkers.
DOI: 10.6084/m9.figshare.21510529.v1
title: Additional file 18 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 18: Table S13. The correlation between discriminant candidate biomarkers.
DOI: 10.6084/m9.figshare.21510550
title: Additional file 7 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 7: Table S2. Read mapping statistics of whole-genome bisulfite sequencing data and RNA sequencing data of six cows.
DOI: 10.6084/m9.figshare.21510514
title: Additional file 13 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 13: Table S8. The list of differentially methylated haplotype blocks (dMHBs) and functional enrichment for hyper dMHBs.
DOI: 10.6084/m9.figshare.21510550.v1
title: Additional file 7 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 7: Table S2. Read mapping statistics of whole-genome bisulfite sequencing data and RNA sequencing data of six cows.
DOI: 10.6084/m9.figshare.21510508
title: Additional file 11 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 11: Table S6. The list of genes harboring DMCs or overlapping with DMRs.
DOI: 10.6084/m9.figshare.14694948
title: Association between AKT2 gene polymorphism and polycystic ovary syndrome: a case-control study

description: This study was conducted to understand the association between the AKT2 (AKT serine/threonine kinase 2) gene polymorphism (rs2304186) and PCOS. In total, 1287 participants were included. Six genotype models (Dominant model: TT + TG vs. GG; Recessive model: TT vs. TG + GG; Over-dominant model: TT + GG vs. TG; Co-dominant model: TT vs. TG; Co-dominant TT vs. GG; Allele analysis: T vs. G) were applied in the analysis. According to the races and obesity, subgroup analyses were also performed. No significant association between rs2304186 and PCOS was identified in the whole sample or the Han groups, even after multi-adjustments. Only in the Zhuang groups was it suggested that rs2304186 might promote the risk of PCOS to some extent (Unadjusted: Over-dominant TT + GG vs. TG, OR = 1.522, 95%CI = 1.076–2.152, <i>p</i> = .018; Age-adjusted: Over-dominant TT + GG vs. TG, OR = 1.543, 95%CI = 1.069–2.228, <i>p</i> = .021; Multi-adjusted: OR = 1.497, 95%CI = 1.024–2.188, <i>p</i> = .037). The risk effect was also detected in the non-obesity group (BMI &lt;24.0 kg/m<sup>2</sup>) for the Co-dominant model (TT vs. TG: OR = 1.355, 95%CI = 1.001–1.835, <i>p</i> = .050). In summary, we first discovered that rs2304186 might significantly elevate the PCOS risk, especially in the Chinese Zhuang population and the non-obesity group. Further studies are needed to confirm these results.
DOI: 10.6084/m9.figshare.21510526
title: Additional file 17 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 17: Table S12. The cluster of functional annotations enriched by differential methylated and expressed genes (MetGDE genes).
DOI: 10.6084/m9.figshare.21510505
title: Additional file 10 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 10: Table S5. The list of DMRs and annotation.
DOI: 10.6084/m9.figshare.21510505.v1
title: Additional file 10 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 10: Table S5. The list of DMRs and annotation.
DOI: 10.6084/m9.figshare.21510508.v1
title: Additional file 11 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

description: Additional file 11: Table S6. The list of genes harboring DMCs or overlapping with DMRs.
DOI: 10.15156/bio/sh076535.07fu
title: SH076535.07FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh076536.07fu
title: SH076536.07FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh076537.07fu
title: SH076537.07FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.