cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.16729664
title: Entropy-Resistant Folding Motifs as a Potential Strategy for Cancer Therapy

description: **Abstract:**

This preprint explores a speculative but structured idea in cancer biology: the introduction of entropy-resistant protein motifs as a therapeutic strategy. The concept is inspired by thermophilic proteins, repetitive folding units, and the stability of certain glycine-proline-rich sequences under high entropic stress. While untested, the proposal is grounded in molecular folding logic and seeks to open a path toward synthetic folding environments that disrupt or outcompete oncogenic protein behaviors.

 

---

 

**Introduction:**

Cancer cells thrive in highly dynamic and chaotic environments. Their proteomes must fold, refold, and misfold constantly under oxidative stress, DNA damage, metabolic shifts, and inflammatory signals. Yet, they persist — suggesting some form of robustness to entropy.

 

Rather than attacking tumors via toxicity or gene expression interference, this idea suggests a third option: introducing highly ordered protein motifs that are difficult to unfold or misfold. If properly designed, such motifs could act as "anchors" of order, disrupting the folding entropy landscape inside tumor cells.

 

This is not a therapy — it is a theoretical concept that has not been tested in vitro or in vivo.

 

---

 

**Main Concept:**

We define an *entropy-resistant motif* as a small synthetic folding unit that:

 

* Has a strong native state,

* Resists denaturation under intracellular thermal fluctuation,

* Can be produced in cells via gene delivery or peptide injection,

* Does not rely on lock-and-key active binding, but rather exerts passive thermodynamic pressure.

 

This is inspired by repeat-protein domains (like ankyrins), designed beta-hairpins, and proline-glycine helices in extremophile organisms.

 

In cancer, where misfolded proteins trigger adaptive survival mechanisms, a sudden excess of over-stable structures might impair the cell’s ability to maintain folding homeostasis — leading to selective stress.

 

---

 

**Potential Implications:**

 

* May function as a *thermodynamic sink* in protein folding environments

* Could interfere with chaperone regulation (e.g. HSP90)

* Might compete for translation or folding machinery resources

* Could be modified to target specific tumor cell types

 

---

 

**Next Steps / Future Directions:**

 

* Computational modeling of folding persistence under stress

* Screening for naturally occurring motifs with high folding resistance

* Experimental testing in yeast or bacterial systems before mammalian models

* Collaboration with structural biologists to design custom sequences

 

---

 

**Disclaimer:**

This is a conceptual exploration. No experiments have been performed. The preprint is shared with the hope of inspiring theoretical and practical feedback from the scientific community.
DOI: 10.15468/dl.2wvpcp
title: Occurrence Download

description: A dataset containing 232 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Elsholtzia ciliata",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 232 records from 33 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000018-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.16729663
title: Entropy-Resistant Folding Motifs as a Potential Strategy for Cancer Therapy

description: **Abstract:**

This preprint explores a speculative but structured idea in cancer biology: the introduction of entropy-resistant protein motifs as a therapeutic strategy. The concept is inspired by thermophilic proteins, repetitive folding units, and the stability of certain glycine-proline-rich sequences under high entropic stress. While untested, the proposal is grounded in molecular folding logic and seeks to open a path toward synthetic folding environments that disrupt or outcompete oncogenic protein behaviors.

 

---

 

**Introduction:**

Cancer cells thrive in highly dynamic and chaotic environments. Their proteomes must fold, refold, and misfold constantly under oxidative stress, DNA damage, metabolic shifts, and inflammatory signals. Yet, they persist — suggesting some form of robustness to entropy.

 

Rather than attacking tumors via toxicity or gene expression interference, this idea suggests a third option: introducing highly ordered protein motifs that are difficult to unfold or misfold. If properly designed, such motifs could act as "anchors" of order, disrupting the folding entropy landscape inside tumor cells.

 

This is not a therapy — it is a theoretical concept that has not been tested in vitro or in vivo.

 

---

 

**Main Concept:**

We define an *entropy-resistant motif* as a small synthetic folding unit that:

 

* Has a strong native state,

* Resists denaturation under intracellular thermal fluctuation,

* Can be produced in cells via gene delivery or peptide injection,

* Does not rely on lock-and-key active binding, but rather exerts passive thermodynamic pressure.

 

This is inspired by repeat-protein domains (like ankyrins), designed beta-hairpins, and proline-glycine helices in extremophile organisms.

 

In cancer, where misfolded proteins trigger adaptive survival mechanisms, a sudden excess of over-stable structures might impair the cell’s ability to maintain folding homeostasis — leading to selective stress.

 

---

 

**Potential Implications:**

 

* May function as a *thermodynamic sink* in protein folding environments

* Could interfere with chaperone regulation (e.g. HSP90)

* Might compete for translation or folding machinery resources

* Could be modified to target specific tumor cell types

 

---

 

**Next Steps / Future Directions:**

 

* Computational modeling of folding persistence under stress

* Screening for naturally occurring motifs with high folding resistance

* Experimental testing in yeast or bacterial systems before mammalian models

* Collaboration with structural biologists to design custom sequences

 

---

 

**Disclaimer:**

This is a conceptual exploration. No experiments have been performed. The preprint is shared with the hope of inspiring theoretical and practical feedback from the scientific community.
DOI: 10.15468/dl.kteqvm
title: Occurrence Download

description: A dataset containing 26495 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Epinecrophylla fulviventris)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "License is one of (CC-BY 4.0, CC0 1.0)"
 ]
}

 The dataset includes 26495 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000020-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.regqya
title: Occurrence Download

description: A dataset containing 9603 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Aves)",
 "HasCoordinate is one of (true)",
 "Geometry POLYGON((-80.4930402739628 -0.635507070601221,-80.2635857128794 -0.635507070601221,-80.2635857128794 -0.24786186985294,-80.4930402739628 -0.24786186985294,-80.4930402739628 -0.635507070601221))"
 ]
}

 The dataset includes 9603 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000019-250802193616735/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pg4nwy
title: Occurrence Download

description: A dataset containing 241979 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Amanita muscaria"
 ]
}

 The dataset includes 241979 records from 468 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0093594-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4fe6jg
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Phaethontiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-60 20,-50 20,-50 30,-60 30,-60 20))"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022394-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.cnws9j
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Phaethontiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-50 20,-40 20,-40 30,-50 30,-50 20))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022392-251009101135966/datasets/export for details.
DOI: 10.15468/dl.23hptq
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Cuculiformes)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((-20 -70,-10 -70,-10 -60,-20 -60,-20 -70))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022393-251009101135966/datasets/export for details.
DOI: 10.15468/dl.qxbbqy
title: Occurrence Download

description: A dataset containing 3253 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ophioglossum petiolatum"
 ]
}

 The dataset includes 3253 records from 175 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022396-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h79wu8
title: Occurrence Download

description: A dataset containing 137 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Salsola tragus",
 "Country is Sweden",
 "HasCoordinate is true"
 ]
}

 The dataset includes 137 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0022395-251009101135966/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/cc92g2w
title: CCDC 270477: Experimental Crystal Structure Determination

description: Related Article: H.M.Ali, S.N.A.Halim, W.J.Basirun, S.W.Ng|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o916|doi:10.1107/S1600536805006628
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc92g3x
title: CCDC 270478: Experimental Crystal Structure Determination

description: Related Article: H.M.Ali, S.N.A.Halim, W.J.Basirun, S.W.Ng|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o1093|doi:10.1107/S160053680500663X
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc92g4y
title: CCDC 270479: Experimental Crystal Structure Determination

description: Related Article: V.Stacy, G.Crundwell, J.B.Updegraff III, M.Zeller, A.D.Hunter|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o904|doi:10.1107/S1600536805006793
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc92g5z
title: CCDC 270480: Experimental Crystal Structure Determination

description: Related Article: J.A.Schachner, C.L.Lund, J.W.Quail, J.Muller|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|m682|doi:10.1107/S1600536805007695
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc91mzx
title: CCDC 269699: Experimental Crystal Structure Determination

description: Related Article: Ye Gao, S.W.Arritt, B.Twamley, J.M.Shreeve|2005|Inorg.Chem.|44|1704|doi:10.1021/ic048513k
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc534hw
title: CCDC 151977: Experimental Crystal Structure Determination

description: Related Article: H.R.Memarian, M.Dehghani, G.Henkel, D.Dopp|2004|Monatsh.Chem.|135|425|doi:10.1007/s00706-003-0115-0
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc91n0z
title: CCDC 269700: Experimental Crystal Structure Determination

description: Related Article: A.Lemire, D.Beaudoin, M.Grenon, A.B.Charette|2005|J.Org.Chem.|70|2368|doi:10.1021/jo048216x
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc534jx
title: CCDC 151978: Experimental Crystal Structure Determination

description: Related Article: H.R.Memarian, M.Dehghani, G.Henkel, D.Dopp|2004|Monatsh.Chem.|135|425|doi:10.1007/s00706-003-0115-0
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7k2d7
title: CCDC 224948: Experimental Crystal Structure Determination

description: Related Article: Ibrahim El-Sayed|2004|Monatsh.Chem.|135|879|doi:10.1007/s00706-004-0165-y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc76r7d
title: CCDC 215023: Experimental Crystal Structure Determination

description: Related Article: Usama El-Ayaan|2004|Monatsh.Chem.|135|919|doi:10.1007/s00706-004-0181-y
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc77dvp
title: CCDC 215662: Experimental Crystal Structure Determination

description: Related Article: S.Mahboobi, A.Sellmer, T.Burgemeister, A.Lyssenko, D.Schollmeyer|2004|Monatsh.Chem.|135|333|doi:10.1007/s00706-003-0085-2
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7738t
title: CCDC 215365: Experimental Crystal Structure Determination

description: Related Article: M.Schaefer, C.Nather, W.Bensch|2004|Monatsh.Chem.|135|461|doi:10.1007/s00706-003-0140-z
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7g00p
title: CCDC 221991: Experimental Crystal Structure Determination

description: Related Article: S.Kirsch, O.Ackermann, K.Harms, T.Bach|2004|Monatsh.Chem.|135|713|doi:10.1007/s00706-003-0153-7
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7gc34
title: CCDC 222335: Experimental Crystal Structure Determination

description: Related Article: B.Dugovic, L.Fisera, C.Hametner, M.K.Cyranski, N.Pronayova|2004|Monatsh.Chem.|135|685|doi:10.1007/s00706-003-0144-8
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7mtl7
title: CCDC 227589: Experimental Crystal Structure Determination

description: Related Article: B.Ghosh, V.J.Catalano, D.A.Lightner|2004|Monatsh.Chem.|135|1305|doi:10.1007/s00706-004-0216-4
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7mtm8
title: CCDC 227590: Experimental Crystal Structure Determination

description: Related Article: B.Ghosh, V.J.Catalano, D.A.Lightner|2004|Monatsh.Chem.|135|1305|doi:10.1007/s00706-004-0216-4
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7fx4p
title: CCDC 221902: Experimental Crystal Structure Determination

description: Related Article: R.Mazurkiewicz, A.Kuznik, M.Grymel, N.Kuznik|2004|Monatsh.Chem.|135|807|doi:10.1007/s00706-003-0167-1
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc7fx3n
title: CCDC 221901: Experimental Crystal Structure Determination

description: Related Article: R.Mazurkiewicz, A.Kuznik, M.Grymel, N.Kuznik|2004|Monatsh.Chem.|135|807|doi:10.1007/s00706-003-0167-1
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc91n76
title: CCDC 269707: Experimental Crystal Structure Determination

description: Related Article: Yang Cai, A.Ellern, J.H.Espenson|2005|Inorg.Chem.|44|2560|doi:10.1021/ic048598p
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc99h13
title: CCDC 277234: Experimental Crystal Structure Determination

description: Related Article: M.Barys, Z.Ciunik|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o1967|doi:10.1107/S1600536805016922
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/cc99h24
title: CCDC 277235: Experimental Crystal Structure Determination

description: Related Article: Hui Zhang, Liang Fang, Runzhang Yuan|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|m1391|doi:10.1107/S1600536805019069
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.