cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21592747
title: Additional file 10 of A novel small molecule glycolysis inhibitor WZ35 exerts anti-cancer effect via metabolic reprogramming

description: Additional file 10: Table S1 The table listing about the 1348 upregulated genes in HCC patients. Table S2. The table listing the upregulated genes based on YAP-related subgroup analysis of HCC patients.
DOI: 10.6084/m9.figshare.7961435.v1
title: Additional file 8: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

description: Figure S3. A: Heatmaps of dysregulated mRNAs expression between sh-control and sh-URRCC groups in the treated A498 cells. B: Volcano plots of the differentially expressed mRNAs. Green and red spots represent p value less than 0.05. Red spots represent fold change more than 2.0. Green spots represent fold change less than 0.5. C: JMY mRNA level in ccRCC tissues compared with normal renal tissues from TCGA KIRC dataset. D: Kaplan–Meier analyses of the correlations between URRCC expression and overall survival of 530 ccRCC patients from TCGA KIRC dataset. Log-rank test was used to calculate p values. E: Correlation between URRCC and EGFL7 in mRNA level in cell lines. F: mRNA level of EGFL7 in different treatment groups. G and H: ChIP analyses of A498 and OSRC-2 cells treated with sh-control, sh-URRCC or sh-URRCC+TSA(100 nM) were conducted on the EGFL7 promoter regions using anti-acetyl-histone H3 and anti-acetyl-histone H4. Enrichment was determined relative to input controls. I: Representative Ki67 IHC staining of xenograft tumors from sh-control, sh-URRCC, mock, and oe-URRCC groups (200×, 400×). (ZIP 220 kb)
DOI: 10.6084/m9.figshare.12680037
title: Additional file 1 of Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony

description: Additional file 1: Table S1. Sample information for each horse (86 individuals) used in this study. Table S2. Number of SNPs for each breed. Table S3. Positively selected genes (top %1) identified by Fst method. Table S4. Overrepresented GO categories among genes showing high Fst values in DBP. Table S5. Positively selected genes identified by top 1% highest log2 (θπ·DBP/θπ·THB). Table S6. Gene functional enrichment categories showing high log2(θπ·DBP/θπ·THB) values in DBP. Table S7. Positively selected genes identified (top%1) by XP-CLR method. Table S8. Gene functional enrichment categories showing high XP-CLR values.
DOI: 10.6084/m9.figshare.6388448.v1
title: PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension

description: Pregnancy-induced hypertension (PIH) causes significant maternal and fetal morbidity and mortality. A decreased number of regulatory T (Treg) cells is associated with the pathogenesis of PIH. The programmed cell death-1 (PD-1)/PD-ligand 1 (PD-L1) pathway is critical to normal pregnancy (NP) by promoting Treg cell development. However, the relationship between PD-1/PD-L1 and Treg differentiation in PIH has not been fully elucidated. In this study, venous blood was obtained from 20 NP and 58 PIH patients. Peripheral blood mononuclear cells (PBMCs) were isolated from venous blood. The levels of Treg-related cytokines (TGF-β, IL-10, and IL-35) in serum and PBMCs were measured by ELISA. The percentage of Treg cells in PBMCs was assessed by flow cytometry. The mRNA levels of Treg-specific transcription factor Foxp3 in PBMCs, and PD-1 and PD-L1 in Treg cells were detected by qRT-PCR. The protein levels of PD-1 and PD-L1 in Treg cells were evaluated by western blot. The serum levels of TGF-β, IL-10, IL-35, and Foxp3 mRNA expression and CD4+CD25+ Treg cell percentage in PBMCs were decreased in PIH. Furthermore, a significant increase of PD-1 in Treg cells was found in PIH compared with NP. In addition, PD-L1 Fc, an activator of PD-1/PD-L1 pathway, increased Treg cell percentage, enhanced Foxp3 mRNA expression, and elevated levels of TGF-β, IL-10, and IL-35 in PBMCs. However, anti-PD-L1 mAb exerted a reverse effect. These findings revealed that PD-L1 Fc had a favorable effect on Treg cell differentiation, indicating a potential therapeutic value of PD-1/PD-L1 pathway for PIH treatment.
DOI: 10.6084/m9.figshare.7961360
title: Additional file 13: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

description: Figure S4. A: Bioinformatics analysis of potential FOXO3 binding site on URRCC promoter by online software RegRNA 2.0. B: Correlation between URRCC and FOXO3 in mRNA level in cell lines. C and D: The mRNA level of URRCC and EGFL7 were detected by qRT-PCR in A498 and OSRC-2 cells after transfection with si-NC or si-FOXO3. E and F: The mRNA level of URRCC and EGFL7 were detected by qRT-PCR in A498 and OSRC-2 cells after transfection with NC or oe-FOXO3. G and H: Cell apoptosis assays by flow cytometry in A498 cell lines.Â (ZIP 209 kb)
DOI: 10.6084/m9.figshare.6388466
title: Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population

description: Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
DOI: 10.6084/m9.figshare.7961333.v1
title: Additional file 10: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

description: Table S7. JMY expression in ccRCC and normal renal samples from TCGA KIRC dataset. (XLS 27 kb)
DOI: 10.7488/ds/7680
title: p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003

description: Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to 85 different sites, and there is increasing interest in whether tau phosphorylation at specific epitopes, by specific kinases, plays an important role in disease progression. The AMP-activated protein kinase (AMPK)-related enzyme NUAK1 has been identified as a potential mediator of tau pathology, whereby NUAK1-mediated phosphorylation of tau at Ser356 prevents the degradation of tau by the proteasome, further exacerbating tau hyperphosphorylation and accumulation. This study provides a detailed characterisation of the association of p-tau Ser356 with progression of Alzheimer’s disease pathology, identifying a Braak stage-dependent increase in p-tau Ser356 protein levels and an almost ubiquitous presence in neurofibrillary tangles. We also demonstrate, using sub-diffraction-limit resolution array tomography imaging, that p-tau Ser356 co-localises with synapses in AD postmortem brain tissue, increasing evidence that this form of tau may play important roles in AD progression. To assess the potential impacts of pharmacological NUAK inhibition in an ex vivo system that retains multiple cell types and brain-relevant neuronal architecture, we treated postnatal mouse organotypic brain slice cultures from wildtype or APP/PS1 littermates with the commercially available NUAK1/2 inhibitor WZ4003. Whilst there were no genotype-specific effects, we found that WZ4003 results in a culture-phase-dependent loss of total tau and p-tau Ser356, which corresponds with a reduction in neuronal and synaptic proteins. By contrast, application of WZ4003 to live human brain slice cultures results in a specific lowering of p-tau Ser356, alongside increased neuronal tubulin protein. This work identifies differential responses of postnatal mouse organotypic brain slice cultures and adult human brain slice cultures to NUAK1 inhibition that will be important to consider in future work developing tau-targeting therapeutics for human disease. This dataset refers to the publication ( https://doi.org/10.1007/s00401-023-02667-w ).
DOI: 10.6084/m9.figshare.22637941.v1
title: Additional file 4 of Functional gene-guided enrichment plus in situ microsphere cultivation enables isolation of new crucial ureolytic bacteria from the rumen of cattle

description: Additional file 4: Supplementary Table 4. The similarity of UreC amino acid sequences of the isolates with urease gene cluster type I.
DOI: 10.6084/m9.figshare.7961558.v1
title: Additional file 8: of The effects of yoga compared to active and inactive controls on physical function and health related quality of life in older adults- systematic review and meta-analysis of randomised controlled trials

description: (i)Â Risk of bias details for physical function outcomes. (ii)Â Risk of bias details for HRQoL outcomes. This excel file has two tabs with the risk of bias details for physical function and HRQoL outcomes. (XLSX 25 kb)
DOI: 10.6084/m9.figshare.22637932
title: Additional file 1 of Functional gene-guided enrichment plus in situ microsphere cultivation enables isolation of new crucial ureolytic bacteria from the rumen of cattle

description: Additional file 1: Supplementary Table 1. Summary of genome features of the ureolytic bacterial isolates.
DOI: 10.6084/m9.figshare.21592795
title: Additional file 2 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 2: Table S1. Differentially upregulated genes in DBS group at 16 h compared with 4 h following oviposition.
DOI: 10.6084/m9.figshare.22637944.v1
title: Additional file 5 of Functional gene-guided enrichment plus in situ microsphere cultivation enables isolation of new crucial ureolytic bacteria from the rumen of cattle

description: Additional file 5: Supplementary Table 5. The ureolytic bacteria whose genome were used for pan-genome analysis.
DOI: 10.6084/m9.figshare.21592819
title: Additional file 9 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 9: Table S8. Differential metabolites between LBS and DBS groups at 22 h following oviposition in uterine fluid.
DOI: 10.6084/m9.figshare.7961354.v1
title: Additional file 12: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

description: Table S9. EGFL7 expression in ccRCC and normal renal samples from TCGA KIRC dataset. (XLS 26 kb)
DOI: 10.6084/m9.figshare.7961492
title: Additional file 10: of The effects of yoga compared to active and inactive controls on physical function and health related quality of life in older adults- systematic review and meta-analysis of randomised controlled trials

description: Frequency and duration of yoga sessions from studies included in the systematic review. This is a cross-tab of frequency and duration of yoga interventions from studies included in the meta-analysis. (XLSX 9 kb)
DOI: 10.5281/zenodo.10636438
title: melanotaenia_catherinae_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.5281/zenodo.10636439
title: melanotaenia_catherinae_decontaminated_FSCR.fasta.gz

description: .
DOI: 10.6084/m9.figshare.13129037.v5
title: Arctic COSMO-CLM hindcast 1992

description: COSMO-CLM Russian Arctic climate dataset
DOI: 10.6084/m9.figshare.21592795.v1
title: Additional file 2 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 2: Table S1. Differentially upregulated genes in DBS group at 16 h compared with 4 h following oviposition.
DOI: 10.6084/m9.figshare.21592801.v1
title: Additional file 3 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 3: Table S2. Differentially upregulated genes in DBS group at 22 h compared with 4 h following oviposition.
DOI: 10.6084/m9.figshare.21592804.v1
title: Additional file 4 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 4: Table S3. Differentially upregulated genes in DBS group compared with WS group at 16 h following oviposition.
DOI: 10.6084/m9.figshare.21592804
title: Additional file 4 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 4: Table S3. Differentially upregulated genes in DBS group compared with WS group at 16 h following oviposition.
DOI: 10.6084/m9.figshare.21592810
title: Additional file 6 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 6: Table S5. Differential metabolites between LBS and DBS groups at 6 h following oviposition in shell glands.
DOI: 10.6084/m9.figshare.21592807.v1
title: Additional file 5 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 5: Table S4. Differentially upregulated genes in DBS group compared with WS group at 22 h following oviposition.
DOI: 10.6084/m9.figshare.21592816
title: Additional file 8 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 8: Table S7. Differential metabolites between LBS and DBS groups at 6 h following oviposition in uterine fluid.
DOI: 10.6084/m9.figshare.7961687.v1
title: Additional file 1: of Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy

description: Table S1. Information of the qRT-PCR primer, siRNA and shRNA sequence. (XLSX 174 kb)
DOI: 10.6084/m9.figshare.21592819.v1
title: Additional file 9 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

description: Additional file 9: Table S8. Differential metabolites between LBS and DBS groups at 22 h following oviposition in uterine fluid.
DOI: 10.6084/m9.figshare.7961345.v1
title: Additional file 11: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

description: Table S8. JMY expression and paitientsâ survival time from TCGA KIRC dataset. (XLS 19 kb)
DOI: 10.6084/m9.figshare.21592805
title: Additional file 5 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

description: Additional file 5: Table S5. Immunity genes with differential promoter coverage in all trisomic pregnant women.
DOI: 10.6084/m9.figshare.21592793.v1
title: Additional file 2 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

description: Additional file 2: Table S2. Differential promoter coverage genes and GO, KEGG enrichment analysis results of differential genes for pregnant women with trisomy 21.
DOI: 10.6084/m9.figshare.21592799.v1
title: Additional file 3 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

description: Additional file 3: Table S3. Differential promoter coverage genes and GO, KEGG enrichment analysis results of differential genes for pregnant women with trisomy 18.
DOI: 10.6084/m9.figshare.21592790.v1
title: Additional file 1 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

description: Additional file 1: Table S1. Differential promoter coverage genes and GO, KEGG enrichment analysis results of differential genes for all pregnant women with trisomy.
DOI: 10.6084/m9.figshare.21592799
title: Additional file 3 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

description: Additional file 3: Table S3. Differential promoter coverage genes and GO, KEGG enrichment analysis results of differential genes for pregnant women with trisomy 18.
DOI: 10.6084/m9.figshare.7961354
title: Additional file 12: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

description: Table S9. EGFL7 expression in ccRCC and normal renal samples from TCGA KIRC dataset. (XLS 26 kb)
DOI: 10.15468/dl.qnk6kk
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Machine Observation",
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Material sample",
 "BasisOfRecord is Specimen"
 ]
 },
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Ananthidium Urban, 1991",
 "Year 1960-2021"
 ]
}

 The dataset includes 21 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0293527-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.539wbw
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is USA.41_1",
 "TaxonKey is Pieris virginiensis Edwards, 1870"
 ]
}

 The dataset includes 4 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0318080-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pdf6cj
title: Occurrence Download

description: A dataset containing 1521 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Kenya",
 "Geometry POLYGON((35.50827 2.46048,36.2114 2.46048,36.2114 3.1636,35.50827 3.1636,35.50827 2.46048))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 1521 records from 28 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008928-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6gamsl
title: Occurrence Download

description: A dataset containing 3175663 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((26.7542939189847 1.2186193716968,36.9991642472184 13.6345880476356,41.544901412726 10.038706409249,37.5419388341447 2.16847489881781,35.84576825 -7.80500813595271,36.2528491901947 -16.0144737632128,34.2174444892211 -16.5572483501391,27.5006089760084 -8.95840413317107,26.7542939189847 1.2186193716968))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3175663 records from 701 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034945-200221144449610/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8g62we
title: Occurrence Download

description: A dataset containing 1354 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Boana lanciformis (Cope, 1871)"
 ]
}

 The dataset includes 1354 records from 56 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002410-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6c35n8
title: Occurrence Download

description: A dataset containing 33259 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Scutelleridae)",
 "HasCoordinate is true"
 ]
}

 The dataset includes 33259 records from 306 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0036069-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mhbczw
title: Occurrence Download

description: A dataset containing 20595 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((28.746 -28.425,30.6 -28.425,30.6 -26.462,28.746 -26.462,28.746 -28.425))",
 "HasCoordinate is true",
 "TaxonKey is Plantae",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 20595 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0008928-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wjofbu
title: Occurrence Download

description: A dataset containing 93 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Lasius neglectus Van Loon, Boomsma & Andrasfalvy, 1990"
 ]
}

 The dataset includes 93 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0003093-180412121330197/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6cgnnr
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Bassaricyon neblina Helgen, Pinto, Kays, Helgen, Tsuchiya, Quinn, Wilson & Maldonado, 2013"
 ]
}

 The dataset includes 58 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002426-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.n2hmz6
title: Occurrence Download

description: A dataset containing 12138 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Puma concolor (Linnaeus, 1771)"
 ]
}

 The dataset includes 12138 records from 236 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0067718-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8g22x3
title: Occurrence Download

description: A dataset containing 646 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Mariposas de la expedición al Río Apaporis - Proyecto Colombia BIO"
 ]
}

 The dataset includes 646 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0365676-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.