cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10610237
title: HyperVein: A Dataset for Human Vein Detection from Hyperspectral Images

description: This folder contains a subset of hyperspectral images from the "HyperVein: A Dataset for Human Vein Detection from Hyperspectral Images" dataset, which originally consists of 200 images.

This folder includes:

1. A hyperspectral image dataset containing 10 hyperspectral images representing the left and right hand image capture of 5 volunteer participants. The images named with 'a' (e.g. 1a.bil) are left-hand images and those named with 'b' (e.g. 1b.bil) are right-hand images. Both the image file in band interleaved format (.bil) and the header (.hdr) file have been provided for each image. 

2. A dataset containing the ground truth for each of the hyperspectral images. The ground truths are of dimensions 1024 by 1024 representing the selected ROI used for the vein detection experiment. This region can be mapped out using dimensions: row = 291:1314, column = 360:1383. A folder containing the ground truth images scaled to 0 and 255 for visualization purposes is also included.

3. An example MATLAB file for reading and displaying the hyperspectral images named 'Read_HS_Image'. Make sure to download and install the Hyperspectral Image Processing Toolbox on MATLAB first before running codes.
DOI: 10.5281/zenodo.10610238
title: HyperVein: A Dataset for Human Vein Detection from Hyperspectral Images

description: This folder contains a subset of hyperspectral images from the "HyperVein: A Dataset for Human Vein Detection from Hyperspectral Images" dataset, which originally consists of 200 images.

This folder includes:

1. A hyperspectral image dataset containing 10 hyperspectral images representing the left and right hand image capture of 5 volunteer participants. The images named with 'a' (e.g. 1a.bil) are left-hand images and those named with 'b' (e.g. 1b.bil) are right-hand images. Both the image file in band interleaved format (.bil) and the header (.hdr) file have been provided for each image. 

2. A dataset containing the ground truth for each of the hyperspectral images. The ground truths are of dimensions 1024 by 1024 representing the selected ROI used for the vein detection experiment. This region can be mapped out using dimensions: row = 291:1314, column = 360:1383. A folder containing the ground truth images scaled to 0 and 255 for visualization purposes is also included.

3. An example MATLAB file for reading and displaying the hyperspectral images named 'Read_HS_Image'. Make sure to download and install the Hyperspectral Image Processing Toolbox on MATLAB first before running codes.
DOI: 10.5281/zenodo.10610550
title: Dataset: Surfactant production of Pseudomonas spp. causes co-swarming of Pantoea eucalypti 299R

description: Raw and processed data include in vitro and in planta experiments of competition and swarming assays for Pantoea eucalypti 299R (Pe299R) and Pseudomonas sp. FF1 (PFF1) wild type or viscB mutant. 

In vitro:



Plate reader - competition assay between Pe299R and PFF1 (wt or viscB mutant)

Plate reader scan matrix - swarming assays


In planta:



CFU data

CUSPER fluorescence data
DOI: 10.5281/zenodo.10610551
title: Dataset: Surfactant production of Pseudomonas spp. causes co-swarming of Pantoea eucalypti 299R

description: Raw and processed data include in vitro and in planta experiments of competition and swarming assays for Pantoea eucalypti 299R (Pe299R) and Pseudomonas sp. FF1 (PFF1) wild type or viscB mutant. 

In vitro:



Plate reader - competition assay between Pe299R and PFF1 (wt or viscB mutant)

Plate reader scan matrix - swarming assays


In planta:



CFU data

CUSPER fluorescence data
DOI: 10.5281/zenodo.10610638
title: Efficacy of lanadelumab in angioedema due to acquired C1 inhibitor deficiency

description: Suffritti C, Sartorio S, Berra S, Janu VP, Caccia S, Zanichelli A. Efficacy of lanadelumab in angioedema due to acquired C1 inhibitor deficiency. J Allergy Clin Immunol Pract. 2023 Mar;11(3):963-965.e1. doi: 10.1016/j.jaip.2022.10.041. Epub 2022 Nov 13. PMID: 36379410.
DOI: 10.5281/zenodo.10610637
title: Efficacy of lanadelumab in angioedema due to acquired C1 inhibitor deficiency

description: Suffritti C, Sartorio S, Berra S, Janu VP, Caccia S, Zanichelli A. Efficacy of lanadelumab in angioedema due to acquired C1 inhibitor deficiency. J Allergy Clin Immunol Pract. 2023 Mar;11(3):963-965.e1. doi: 10.1016/j.jaip.2022.10.041. Epub 2022 Nov 13. PMID: 36379410.
DOI: 10.15139/s3159m
title: Kuo 2014 genetics data sets
DOI: 10.17615/c6mw23
title: 3-D Attenuation Model of Sierra Negra Volcano, Galapagos
DOI: 10.17615/c66p42
title: Data Supplement to "Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease"
DOI: 10.17615/c6794k
title: Metabolite data of mouse hearts in the early stages of the cardiac fuel switch
DOI: 10.17615/8dqf-e678
title: Supplementary Tables to "Modeling clinical phenotypes with protein function to explain the disease spectrum in patients with CHIP mutations"

description: Monogenetic disorders that cause cerebellar ataxia are characterized by defects in gait and atrophy of the cerebellum, however, patients often suffer from a spectrum of disease, complicating treatment options. Spinocerebellar autosomal recessive 16 (SCAR16) is caused by coding mutations in \textit{STUB1}, a gene that encodes the multi-functional enyzme CHIP (C-terminus of HSC70-interacting protein). The spectrum of disease found in SCAR16 patients includes a wide range in the age of disease onset, cognitive dysfunction, increased tendon reflex, and hypogonadism. Although SCAR16 mutations span the multiple functional domains of CHIP, it is unclear if the location of the mutation contributes to the clinical spectrum of SCAR16 or with changes in the biochemical properties of CHIP. In this study, we examined the associations and relationships between the clinical phenotypes of SCAR16 patients and how they relate to changes in the biophysical, biochemical, and functional properties of the corresponding mutated protein. We found that the severity of ataxia did not correlate with age of onset; however, cognitive dysfunction, increased tendon reflex, and ancestry were able to predict 54\% of the variation in ataxia severity. We further identified domain-specific relationships between biochemical changes in CHIP and clinical phenotypes, and specific biochemical activities that associate selectively to either increased tendon reflex or cognitive dysfunction, suggesting that specific changes to CHIP-HSC70 dynamics contributes to the clinical spectrum of SCAR16. Finally, using linear models of SCAR16 and Monte Carlo simulations, our data support the hypothesis that further inhibiting mutant CHIP activity lessens the severity of SCAR16. Table S1 contains clinical variables. Table S2 contains the biochemical data. Table S3 contains the adjusted P values of the multiple comparisons made in this study.
DOI: 10.15472/9ixuud
title: Listado de las especies de Meloidae (Coleoptera: Tenebrionoidea) de Colombia

description: Este recurso presenta el listado de las especies de la familia Meloidae (Coleoptera: Tenebrionoidea) con ocurrencia conocida para el territorio colombiano. Se listan cuatro subfamilias, ocho tribus, once géneros y 30 especies. 16 especies son consideradas endémicas, pues su distribución solo se indica en Colombia. El listado ha sido compilado a partir de información disponible en los principales catálogos que tratan el grupo y en literatura reciente. Se incluyen las referencias de todas las descripciones originales y de los trabajos de revisión taxonómica.
DOI: 10.6084/m9.figshare.20448540
title: Metabarcoding libraries (fungi; 5.8S-Fun, ITS4-Fun primers) from olive tree leaf samples

description: Fungal pair-end metabarcoding libraries from the paper "Characterization of the olive endophytic community in genotypes displaying a contrasting response to <i>Xylella fastidiosa</i>".<br><b><i>Classification (Ctrl = controls):</i></b><b>SX25 </b>FLD0097.FS3105PR01_fungi<br>SX25 Ctrl FLD0105.FS3105PR01Ctrl_fungi<br><b>SX27 </b>FLD0113.AM2507SN02_fungi<br>SX27 Ctrl FLD0121.AM2507SN02Ctrl_fungi<br><b>SX29 </b>FLD0129.AM2507SN03_fungi<br>SX29 Ctrl FLD0137.AM2507SN03Ctrl_fungi<br><b>SX30 </b>FLD0145.FS1709PA02_fungi<br>SX30 Ctrl FLD0153.FS1709PA02Ctrl_fungi<br><b>SX31</b> FLD0161.FS2407ML01_fungi<br>SX31 Ctrl FLD0169.FS2407ML01Ctrl_fungi<br><b>SX32 </b>FLD0177.LP2011ML01_fungi<br>SX32 Ctrl FLD0185.LP2011ML01Ctrl_fungi<br><b>SX61 </b>FLD0098.FG1505SP02_fungi<br>SX61 Ctrl FLD0106.FG1505SP02Ctrl_fungi<br><b>SX63 </b>FLD0114.FG1905UG01_fungi<br>SX63 Ctrl FLD0122.FG1905UG01Ctrl_fungi<br><b>SX65 </b>FLD0130.FG1905SP01_fungi<br>SX65 Ctrl FLD0138.FG1905SP01Ctrl_fungi<br><b>SX67 </b>FLD0146.FG10502BA01_fungi<br>SX67 Ctrl FLD0154.FG1502BA01Ctrl_fungi<br><b>SX69 </b>FLD0162.FG1905RU01_fungi<br>SX69 Ctrl FLD0170.FG1905RU01Ctrl_fungi<br><b>SX71</b> FLD0178.FG1001BA02_fungi<br>SX71 Ctrl FLD0186.FG1001BA02Ctrl_fungi<br><b>SX73 </b>FLD0099.GL0103CO09_fungi<br>SX73 Ctrl FLD0107.GL0103CO09Ctrl_fungi<br><b>SX75 </b>FLD0115.GL0705CO13_fungi<br>SX75 Ctrl FLD0123.GL0705CO13Ctrl_fungi<br><b>SX77</b> FLD0131.GL08050C16_fungi<br>SX77 Ctrl FLD0139.GL08050C16Ctrl_fungi<br><b>SX79 </b>FLD0147.GL08050C17_fungi<br>SX79 Ctrl FLD0155.GL08050C17Ctrl_fungi<br><b>SX81 </b>FLD0163.GL1912LV14_fungi<br>SX81 Ctrl FLD0171.GL1912LV14Ctrl_fungi<br><b>SX83</b> FLD0179.GL1705LV20_fungi<br>SX83 Ctrl FLD0187.GL1705LV20Ctrl_fungi<br><b>SX85</b> FLD0100.GL2902LQ01_fungi<br>SX85 Ctrl FLD0108.GL2902LQ01Ctrl_fungi<br><b>SX87</b> FLD0116.GL0705CO10_fungi<br>SX87 Ctrl FLD0124.GLO705CO10Ctrl_fungi<br><b>SX89 </b>FLD0132.LP1606GA01_fungi<br>SX89 Ctrl FLD0140.LP1606GA01Ctrl_fungi<br>
DOI: 10.6084/m9.figshare.20448513
title: Metabarcoding libraries (bacteria; CS1, CS2 primers) from olive tree leaf samples

description: Bacterial pair-end metabarcoding libraries from the paper "Characterization of the olive endophytic community in genotypes displaying a contrasting response to <i>Xylella fastidiosa</i>".<br><b><i>Classification (Ctrl = controls):</i></b><b>SX25</b> FLD0097.FS3105PR01<br>SX25 Ctrl FLD0105.FS3105PR01Ctrl<br><b>SX27</b> FLD0113.AM2507SN02<br>SX27 Ctrl FLD0121.AM2507SN02Ctrl<br><b>SX29 </b>FLD0129.AM2507SN03<br>SX29 Ctrl FLD0137.AM2507SN03Ctrl<br><b>SX30 </b>FLD0145.FS1709PA02<br>SX30 Ctrl FLD0153.FS1709PA02Ctrl<br><b>SX31 </b>FLD0161.FS2407ML01<br>SX31 Ctrl FLD0169.FS2407ML01Ctrl<br><b>SX32 </b>FLD0177.LP2011ML01<br>SX32 Ctrl FLD0185.LP2011ML01Ctrl<br><b>SX61 </b>FLD0098.FG1505SP02<br>SX61 Ctrl FLD0106.FG1505SP02Ctrl<br><b>SX63 </b>FLD0114.FG1905UG01<br>SX63 Ctrl FLD0122.FG1905UG01Ctrl<br><b>SX65 </b>FLD0130.FG1905SP01<br>SX65 Ctrl FLD0138.FG1905SP01Ctrl<br><b>SX67 </b>FLD0146.FG10502BA01<br>SX67 Ctrl FLD0154.FG1502BA01Ctrl<br><b>SX69 </b>FLD0162.FG1905RU01<br>SX69 Ctrl FLD0170.FG1905RU01Ctrl<br><b>SX71 </b>FLD0178.FG1001BA02<br>SX71 Ctrl FLD0186.FG1001BA02Ctrl<br><b>SX73 </b>FLD0099.GL0103CO09<br>SX73 Ctrl FLD0107.GL0103CO09Ctrl<br><b>SX75 </b>FLD0115.GL0705CO13<br>SX75 Ctrl FLD0123.GL0705CO13Ctrl<br><b>SX77 </b>FLD0131.GL08050C16<br>SX77 Ctrl FLD0139.GL08050C16Ctrl<br><b>SX79 </b>FLD0147.GL08050C17<br>SX79 Ctrl FLD0155.GL08050C17Ctrl<br><b>SX81 </b>FLD0163.GL1912LV14<br>SX81 Ctrl FLD0171.GL1912LV14Ctrl<br><b>SX83 </b>FLD0179.GL1705LV20<br>SX83 Ctrl FLD0187.GL1705LV20Ctrl<br><b>SX85 </b>FLD0100.GL2902LQ01<br>SX85 Ctrl FLD0108.GL2902LQ01Ctrl<br><b>SX87 </b>FLD0116.GL0705CO10<br>SX87 Ctrl FLD0124.GLO705CO10Ctrl<br><b>SX89</b> FLD0132.LP1606GA01<br>SX89 Ctrl FLD0140.LP1606GA01Ctrl<br><br>
DOI: 10.6084/m9.figshare.25134542
title: RSL - Qualidade no jornalismo - Resultado do teste de confiabilidade

description: Este arquivo apresenta os resultados do teste de confiabilidade aplicado à codificação de trabalhos científicos sobre qualidade no jornalismo.
DOI: 10.6084/m9.figshare.25134542.v2
title: RSL - Qualidade no jornalismo - Resultado do teste de confiabilidade

description: Este arquivo apresenta os resultados do teste de confiabilidade aplicado à codificação de trabalhos científicos sobre qualidade no jornalismo.
DOI: 10.6084/m9.figshare.25134542.v1
title: RSL - Qualidade no jornalismo - Resultado do teste de confiabilidade

description: Este arquivo apresenta os resultados do teste de confiabilidade aplicado à codificação de trabalhos científicos sobre qualidade no jornalismo.
DOI: 10.5281/zenodo.10610719
title: asparagus_racemosus_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.10610720
title: asparagus_racemosus_spades_01.fasta.gz

description: .
DOI: 10.15151/esrf-es-1430229755
title: Investigation of the nematic phase of FeSe by resonant X-ray diffraction

description: We propose to study the nematic phase transition of FeSe by measuring Resonant Elastic X-ray Scattering (REXS) at selected “forbidden” reflections at the Fe K edge. This nematic phase transition is not accompanied by magnetic ordering, unlike in most other Fe-based superconductors, which makes this crystal an excellent opportunity to study the former without the latter and to deepen our understanding of nematic phase transitions in the vast class of Fe-based superconductors. The hk0 forbidden reflections should be extremely sensitive to any change of the local environment of the Fe atoms, due to the high symmetry of the crystallographic sites of Fe. In addition, we will pay attention to other anomalies reported in the physical properties at other temperatures, and we will look for possible intra-unit-cell magnetism at low temperature.
DOI: 10.34740/kaggle/ds/4384044
title: Famous Data Science & Knowledge Channels Comments
DOI: 10.5281/zenodo.10610755
title: acacia_concinna_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.10610756
title: acacia_concinna_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.10610772
title: DuplexModel+MEP

description: The dataset contains four IFC files of duplex house representing the following domains:



Architecutre

Heating & Cooling

Piping

Ventilation
DOI: 10.5281/zenodo.10610773
title: DuplexModel+MEP

description: The dataset contains four IFC files of duplex house representing the following domains:



Architecutre

Heating & Cooling

Piping

Ventilation
DOI: 10.5281/zenodo.10514187
title: Subspace MESE datasets

description: This a a raw dataset acquired on a mouse with brain metastasis which can be used to validate the subspace reconstruction  pipeline available here : https://github.com/aTrotier/PAPER_subspace_MESE

The sequence used is a homemade 3D MESE + CS with a variable density poisson distribution along the ky-kz direction and also varying along the echo times.

This was developped at the CRMSB, UMR 5536, CNRS/University of Bordeaux
DOI: 10.5281/zenodo.10514186
title: Subspace MESE datasets

description: This a a raw dataset acquired on a mouse with brain metastasis which can be used to validate the subspace reconstruction  pipeline available here : https://github.com/aTrotier/PAPER_subspace_MESE

The sequence used is a homemade 3D MESE + CS with a variable density poisson distribution along the ky-kz direction and also varying along the echo times.

This was developped at the CRMSB, UMR 5536, CNRS/University of Bordeaux
DOI: 10.5281/zenodo.10610639
title: Subspace MESE datasets

description: This a a raw dataset acquired on a mouse with brain metastasis which can be used to validate the subspace reconstruction  pipeline available here : https://github.com/aTrotier/PAPER_subspace_MESE

The sequence used is a homemade 3D MESE + CS with a variable density poisson distribution along the ky-kz direction and also varying along the echo times.

This was developped at the CRMSB, UMR 5536, CNRS/University of Bordeaux
DOI: 10.6084/m9.figshare.25134635
title: 20240203_starrydata2

description: All data on Starrydata2, a database of experimental properties in the field of inorganic materials
DOI: 10.6084/m9.figshare.25134635.v1
title: 20240203_starrydata2

description: All data on Starrydata2, a database of experimental properties in the field of inorganic materials
DOI: 10.6073/pasta/5b35f07c8f4c77dd05897907c6f77765
title: Inventory of High-resolution phylogenetic profiles of the planktonic microbial communities (via 16S and 18S rRNA gene amplicons) from Shark River Slough and Taylor Slough, Everglades National Park (FCE LTER), Florida, USA, 2017 - ongoing

description: Planktonic microbial communities mediate many vital biogeochemical processes in wetland ecosystems, yet compared to other aquatic ecosystems, like oceans, lakes, rivers, or estuaries, they remain relatively underexplored. Our study site, the Florida Everglades (USA)—a vast iconic wetland consisting of a slow-moving system of shallow rivers connecting freshwater marshes with coastal mangrove forests and seagrass meadows—is a highly threatened model ecosystem for studying salinity and nutrient gradients, as well as the effects of sea level rise and saltwater intrusion. This dataset provides the first high-resolution phylogenetic profiles of planktonic bacterial and eukaryotic microbial communities (using 16S and 18S rRNA gene amplicons) from these environments. The dataset contains 16S and 18S rRNA data from 2017, and contains 16S rRNA data for monthly (2019) and quarterly water samples (2020-ongoing). The 2017 data are published in Laas et al. 2022. A detailed list of sequence data and their accession numbers in GenBank is provided and will be updated as more data are published.
 
 This data package is an inventory of sequence read archive (SRA) entries available through GenBank BioProject PRJNA525456 (at https://www.ncbi.nlm.nih.gov/bioproject/PRJNA525456) and BioProject PRJNA1018945 (at https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1018945).
 This data package is associated with the following publication:
 Laas, P., Ugarelli, K., Travieso, R., Stumpf, S., Gaiser, E. E., Kominoski, J. S., & Stingl, U. (2022). Water column microbial communities vary along salinity gradients in the Florida Coastal Everglades wetlands. Microorganisms, 10(2), 215. https://doi.org/10.3390/microorganisms10020215
 Instead of citing this package, which is an inventory, please cite the original GenBank data or journal article, as appropriate. Citation guidance for the journal article is available on the respective publisher's website.
DOI: 10.5281/zenodo.10610678
title: Mars Odyssey THEMIS surface spectra from feldspathic terrains

description: These are the surface emissivity spectra published in:

Figure 2 of Rogers, AD, and H Nekvasil (2015), Feldspathic rocks on Mars: Compositional constraints from infrared spectroscopy and possible formation mechanisms. Geophys. Res. Lett., 42, 2619–2626. doi: 10.1002/2015GL063501. 

Figure 1 of Rogers, A. D. and W. H. Farrand (2022), Spectral evidence for alkaline rocks and compositional diversity among feldspathic light-toned terrains on Mars, Icarus, 376, 114883, https://doi.org/10.1016/j.icarus.2022.114883.

If you use these spectra, please cite the above publications. Thank you.
DOI: 10.5281/zenodo.10610679
title: Mars Odyssey THEMIS surface spectra from feldspathic terrains

description: These are the surface emissivity spectra published in:

Figure 2 of Rogers, AD, and H Nekvasil (2015), Feldspathic rocks on Mars: Compositional constraints from infrared spectroscopy and possible formation mechanisms. Geophys. Res. Lett., 42, 2619–2626. doi: 10.1002/2015GL063501. 

Figure 1 of Rogers, A. D. and W. H. Farrand (2022), Spectral evidence for alkaline rocks and compositional diversity among feldspathic light-toned terrains on Mars, Icarus, 376, 114883, https://doi.org/10.1016/j.icarus.2022.114883.

If you use these spectra, please cite the above publications. Thank you.
DOI: 10.25345/c5m03z799
title: MassIVE MSV000093982 - Delineating Bovine Milk Derived Microvesicles from Exosomes Using Proteomics
title: This is a dataset for a publication in revision for the Journal of Proteome Research titled "Delineating Bovine Milk Derived Microvesicles from Exosomes Using Proteomics". The paper explores the extracellular vesicle proteomics of bovine milk treated with a serial ultracentrifugation method that partially separates differently sized particles. We used a clustering method to group proteins with corresponding categories of particles.
DOI: 10.34740/kaggle/dsv/7540506
title: Mahanagar Yatayat Transport Dataset
DOI: 10.34740/kaggle/dsv/7540522
title: MoviesDatasets
DOI: 10.34740/kaggle/ds/4390663
title: 2024 Best-Selling Sunglasses on Amazon 🕶️
DOI: 10.5519/qd.pqdfprlx
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (96 records)
DOI: 10.25829/idiv.3552-phf544
title: Climate regulation processes are linked to the functional composition of the plant community in European forests, shrublands and grasslands
DOI: 10.17615/8d6g-1167
title: Makerspaces in U.S. State Colleges and Universities

description: This is a census of makerspaces in U.S. state colleges and institutions.
DOI: 10.17615/sed5-hr27
title: Langa 18-39y Diet Survey: Taxed and Untaxed Beverages Replication Dataset
DOI: 10.17615/3697-3v58
title: EC50 Dataset for Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

description: EC50 values were determined for a subset of the selected virus cultures against a panel of protease inhibitors.  The highest level of resistance recorded was 100 µM.  Using a novel method described in the methods, these values were then pooled using several different parameters as described in the figure legends.  EC50 inhibition values are shown in Figure 1 and 5.  The Mann-Whitney rank-sum test was used to assess differences in EC50 values.    Around 10% of the curves had one point where the value was >125% infectivity of the first point.  Anomalous values were excluded from curve fitting.  4 curves did not record data.
DOI: 10.17615/rb7r-tx62
title: Km and Ki Dataset for Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

description: Ki values were determined against all UMASS inhibitors (Table 1). Brackets above the bars represent significant p-values between the two groups using the unpaired t-test. Data were pooled in different ways for the following analyses: A) The Ki values against the inhibitors with the larger R1-2 moiety (n=34) were more potent against resistant proteases compared to the inhibitors with the smaller R1-1 moiety (n=35)  B) Ki values for the inhibitors with the R2-2 group (n=10) showed a trend toward being more potent against the highly mutated proteases compared to the other R2 groups (n=40). C) Ki values for enzymes with the I50V mutation (n=33) showed greater resistance to the inhibitors compared to enzymes with the I84V mutation (n=22).  D) The R1-2 moiety provided increased potency to enzymes with the I84V mutation (n=20) but not the I50V mutation (n=20). E) The R2-2 moiety was more potent against the enzymes with I84V mutation (n=10) compared to the enzymes with the I50V mutation (n=10). The unpaired t-test was used to assess differences in Ki values.