cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29329493
title: Genetic Association of Lipid-Lowering Drug Target Genes with Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study

description: The role of lipid-lowering drugs in chronic obstructive pulmonary disease (COPD) is controversial in clinical studies. This study aimed to explore the causal relationship between lipid-lowering drugs and COPD from a genetic perspective, and to evaluate the potential effects of this relationship. Four hundred and thirty-one lipid-related phenotypes and two COPD datasets were obtained from Genome-Wide Association Studies (GWAS) and analysed together using Mendelian randomization (MR). Genetic variants associated with genes encoding targets of lipid-lowering drugs were extracted from the Global Lipid Genetics Consortium. Expression quantitative trait loci data in relevant tissues were adopted to validate lipid-lowering drug targets that reached significance. We found that four lipid abnormalities were associated with COPD risk. Genetically proxied inhibition of HMG-CoA reductase (HMGCR) and PCSK9 is associated with an increased risk of COPD. And there is a significant MR correlation between increased whole blood HMGCR expression and COPD. HMGCR and PCSK9 inhibitors are associated with onset of COPD, lung function, and COPD-associated infections. Mediation analyses were performed to explore potential mediators of how genetically proxied inhibition of HMGCR and PCSK9 influences the risk of COPD through different immune cell phenotypes and inflammatory factor levels. Our findings indicate a potential link between the use of HMGCR and PCSK9 inhibitors and increased risk of COPD and exacerbation of COPD phenotypes. This suggests effects beyond LDL-C modulation, potentially involving immune cell function and inflammatory factors.
DOI: 10.6084/m9.figshare.29329493.v1
title: Genetic Association of Lipid-Lowering Drug Target Genes with Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study

description: The role of lipid-lowering drugs in chronic obstructive pulmonary disease (COPD) is controversial in clinical studies. This study aimed to explore the causal relationship between lipid-lowering drugs and COPD from a genetic perspective, and to evaluate the potential effects of this relationship. Four hundred and thirty-one lipid-related phenotypes and two COPD datasets were obtained from Genome-Wide Association Studies (GWAS) and analysed together using Mendelian randomization (MR). Genetic variants associated with genes encoding targets of lipid-lowering drugs were extracted from the Global Lipid Genetics Consortium. Expression quantitative trait loci data in relevant tissues were adopted to validate lipid-lowering drug targets that reached significance. We found that four lipid abnormalities were associated with COPD risk. Genetically proxied inhibition of HMG-CoA reductase (HMGCR) and PCSK9 is associated with an increased risk of COPD. And there is a significant MR correlation between increased whole blood HMGCR expression and COPD. HMGCR and PCSK9 inhibitors are associated with onset of COPD, lung function, and COPD-associated infections. Mediation analyses were performed to explore potential mediators of how genetically proxied inhibition of HMGCR and PCSK9 influences the risk of COPD through different immune cell phenotypes and inflammatory factor levels. Our findings indicate a potential link between the use of HMGCR and PCSK9 inhibitors and increased risk of COPD and exacerbation of COPD phenotypes. This suggests effects beyond LDL-C modulation, potentially involving immune cell function and inflammatory factors.
DOI: 10.6084/m9.figshare.30530831
title: Impact of Lung Function and COPD on the Prevalence and Mortality of CKM Syndrome: Evidence from a Cross-Sectional Study

description: Chronic obstructive pulmonary disease (COPD) and cardiovascular-kidney-metabolic (CKM) syndrome are major public health concerns, yet their interrelationship remains under-explored. This study investigates the impact of lung function and COPD on the prevalence and mortality of CKM syndrome using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2012. A cross-sectional analysis of 5569 adults was conducted, defining CKM stages per the 2023 American Heart Association framework. Lung function was assessed <i>via</i> prebronchodilator spirometry, with COPD classified using GOLD criteria. Advanced CKM syndrome (stages 3–4) was the primary outcome. Associations were evaluated using survey-weighted logistic regression, restricted cubic splines (RCS), and cox proportional hazards models. Among participants, 10.7% had advanced CKM syndrome. COPD was significantly associated with advanced CKM(adjusted OR = 1.52 [1.11, 2.09]), with escalating risks across GOLD stages (GOLD stage II: OR = 2.13 [1.21, 3.74]; GOLD stage III–IV: OR = 4.38 [1.06, 18.02]). Pre-COPD conditions, including preserved ratio impaired spirometry (PRISm) (OR = 2.62 [1.66, 4.14]) and chronic bronchitis (OR = 2.60 [1.50, 4.53]), also showed significant associations. COPD increased all-cause mortality (HR = 1.40 [1.04, 1.89]) and cardiovascular-related mortality (HR = 1.81 [1.04, 3.14]) in individuals aged ≥50 with advanced CKM. COPD is strongly associated with advanced CKM syndrome and increased mortality. These findings highlight the systemic impact of lung health on CKM progression and outcomes, emphasizing the need for integrated screening and management strategies targeting both pulmonary and cardiometabolic health, especially in older adults.
DOI: 10.6084/m9.figshare.30530831.v1
title: Impact of Lung Function and COPD on the Prevalence and Mortality of CKM Syndrome: Evidence from a Cross-Sectional Study

description: Chronic obstructive pulmonary disease (COPD) and cardiovascular-kidney-metabolic (CKM) syndrome are major public health concerns, yet their interrelationship remains under-explored. This study investigates the impact of lung function and COPD on the prevalence and mortality of CKM syndrome using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2012. A cross-sectional analysis of 5569 adults was conducted, defining CKM stages per the 2023 American Heart Association framework. Lung function was assessed <i>via</i> prebronchodilator spirometry, with COPD classified using GOLD criteria. Advanced CKM syndrome (stages 3–4) was the primary outcome. Associations were evaluated using survey-weighted logistic regression, restricted cubic splines (RCS), and cox proportional hazards models. Among participants, 10.7% had advanced CKM syndrome. COPD was significantly associated with advanced CKM(adjusted OR = 1.52 [1.11, 2.09]), with escalating risks across GOLD stages (GOLD stage II: OR = 2.13 [1.21, 3.74]; GOLD stage III–IV: OR = 4.38 [1.06, 18.02]). Pre-COPD conditions, including preserved ratio impaired spirometry (PRISm) (OR = 2.62 [1.66, 4.14]) and chronic bronchitis (OR = 2.60 [1.50, 4.53]), also showed significant associations. COPD increased all-cause mortality (HR = 1.40 [1.04, 1.89]) and cardiovascular-related mortality (HR = 1.81 [1.04, 3.14]) in individuals aged ≥50 with advanced CKM. COPD is strongly associated with advanced CKM syndrome and increased mortality. These findings highlight the systemic impact of lung health on CKM progression and outcomes, emphasizing the need for integrated screening and management strategies targeting both pulmonary and cardiometabolic health, especially in older adults.
DOI: 10.6084/m9.figshare.28902189
title: Roles of ABCA1 in Chronic Obstructive Pulmonary Disease

description: Chronic obstructive pulmonary disease (COPD) is one of the common chronic respiratory diseases, which causes a heavy burden to patients and society. Increasing studies suggest that ABCA1 plays an important role in COPD. ABCA1 belongs to a large class of ATP-binding (ABC) transporters. It is not only involved in the reverse transport of cholesterol, but also in the regulation of apoptosis, pyroptosis, cellular inflammation and cellular immunity. Meanwhile, ABCA1 is involved in several signaling pathways, such as SREBP pathway, LXR pathway, MAPK pathway, p62/mTOR pathway, CTRP1 pathway and so on. In addition, the ABCA1 participates in the disorder of lipid metabolism in COPD by regulating the formation of RCT and HDL, regulates the inflammation of COPD by removing excess cholesterol in macrophages, and promotes the differentiation of COPD phenotype into emphysema type. Accordingly, the ABCA1 may be a therapeutic target for COPD.
DOI: 10.6084/m9.figshare.28902189.v1
title: Roles of ABCA1 in Chronic Obstructive Pulmonary Disease

description: Chronic obstructive pulmonary disease (COPD) is one of the common chronic respiratory diseases, which causes a heavy burden to patients and society. Increasing studies suggest that ABCA1 plays an important role in COPD. ABCA1 belongs to a large class of ATP-binding (ABC) transporters. It is not only involved in the reverse transport of cholesterol, but also in the regulation of apoptosis, pyroptosis, cellular inflammation and cellular immunity. Meanwhile, ABCA1 is involved in several signaling pathways, such as SREBP pathway, LXR pathway, MAPK pathway, p62/mTOR pathway, CTRP1 pathway and so on. In addition, the ABCA1 participates in the disorder of lipid metabolism in COPD by regulating the formation of RCT and HDL, regulates the inflammation of COPD by removing excess cholesterol in macrophages, and promotes the differentiation of COPD phenotype into emphysema type. Accordingly, the ABCA1 may be a therapeutic target for COPD.
DOI: 10.17632/8kjkd6g2jj
title: Yottasan et al. paper

description: Raw data for Yottasan et al.
DOI: 10.17632/8kjkd6g2jj.1
title: Yottasan et al. paper

description: Raw data for Yottasan et al.
DOI: 10.25574/18905
title: Chandra X-ray Observatory ObsId 18905

description: X-raying the Bones of the Milky Way
DOI: 10.25574/18906
title: Chandra X-ray Observatory ObsId 18906

description: X-raying the Bones of the Milky Way
DOI: 10.25574/18907
title: Chandra X-ray Observatory ObsId 18907

description: X-raying the Bones of the Milky Way
DOI: 10.25574/18908
title: Chandra X-ray Observatory ObsId 18908

description: X-raying the Bones of the Milky Way
DOI: 10.25574/18909
title: Chandra X-ray Observatory ObsId 18909

description: X-raying the Bones of the Milky Way
DOI: 10.25574/18910
title: Chandra X-ray Observatory ObsId 18910

description: X-raying the Bones of the Milky Way
DOI: 10.25574/18912
title: Chandra X-ray Observatory ObsId 18912

description: Cracking the Conundrum of F Supergiant Coronae
DOI: 10.25574/18913
title: Chandra X-ray Observatory ObsId 18913

description: Cracking the Conundrum of F Supergiant Coronae
DOI: 10.25574/18914
title: Chandra X-ray Observatory ObsId 18914

description: Cracking the Conundrum of F Supergiant Coronae
DOI: 10.25574/18915
title: Chandra X-ray Observatory ObsId 18915

description: The HL Tau Jet and X-ray Irradiated Protoplanetary Disk
DOI: 10.25574/18916
title: Chandra X-ray Observatory ObsId 18916

description: An X-ray Census of the Young Stellar Population in a Massive Forming Cluster
DOI: 10.25574/18917
title: Chandra X-ray Observatory ObsId 18917

description: Direct Detection of Accreting White Dwarf Pollutants
DOI: 10.17026/ar/uunsgu
title: PAN-00131976 - iron leaf-shaped spear-/lance head

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00131976&lt;/p&gt;
description: Modified: 2025-09-23T12:49:31+02:00
DOI: 10.25574/18918
title: Chandra X-ray Observatory ObsId 18918

description: Direct Detection of Accreting White Dwarf Pollutants
DOI: 10.25574/18919
title: Chandra X-ray Observatory ObsId 18919

description: Direct Detection of Accreting White Dwarf Pollutants
DOI: 10.25574/18920
title: Chandra X-ray Observatory ObsId 18920

description: Direct Detection of Accreting White Dwarf Pollutants
DOI: 10.25574/18921
title: Chandra X-ray Observatory ObsId 18921

description: An X-ray Census of YSOs in Infrared Dark Clouds. II. Star Cluster Formation from a Massive Filament
DOI: 10.25574/18925
title: Chandra X-ray Observatory ObsId 18925

description: The stellar radio pulsar CU Vir
DOI: 10.25574/18926
title: Chandra X-ray Observatory ObsId 18926

description: PFTO 8-8695b: The youngest exoplanet or a stellar feature?
DOI: 10.25574/18927
title: Chandra X-ray Observatory ObsId 18927

description: Definitive X-Ray Detection of the Class 0 Protostar HOPS 383
DOI: 10.25574/18928
title: Chandra X-ray Observatory ObsId 18928

description: Cepheids: The first rung on the cosmic distance ladder: Part II: Polaris
DOI: 10.25574/18929
title: Chandra X-ray Observatory ObsId 18929

description: Using the sharp Chandra's eyes to find a neutron star lurking in the wind of WR124
DOI: 10.25574/18930
title: Chandra X-ray Observatory ObsId 18930

description: What is the hottest cool star?
DOI: 10.25574/18931
title: Chandra X-ray Observatory ObsId 18931

description: What is the hottest cool star?
DOI: 10.25574/18932
title: Chandra X-ray Observatory ObsId 18932

description: What is the hottest cool star?
DOI: 10.25574/18933
title: Chandra X-ray Observatory ObsId 18933

description: What is the hottest cool star?
DOI: 10.25574/18934
title: Chandra X-ray Observatory ObsId 18934

description: Chandra/ACIS-I observations of W3-AFGL333: Studying Feedback from Massive stars on Circumstellar Disk Evolution
DOI: 10.25574/18935
title: Chandra X-ray Observatory ObsId 18935

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18936
title: Chandra X-ray Observatory ObsId 18936

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18937
title: Chandra X-ray Observatory ObsId 18937

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18938
title: Chandra X-ray Observatory ObsId 18938

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18939
title: Chandra X-ray Observatory ObsId 18939

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18940
title: Chandra X-ray Observatory ObsId 18940

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.15468/dl.qn38ux
title: Occurrence Download

description: A dataset containing 318 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Calliactis tricolor",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 {
 "or" : [
 "CoordinateUncertaintyInMeters is less than 10000",
 "CoordinateUncertaintyInMeters is null"
 ]
 }
 ]
}

 The dataset includes 318 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055536-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.14498608
title: Size at metamorphosis

description: We measured size at metamorphosis of Bufo japonicus in the field. We then examined evolutionary response by employing a common garden experiment.

Field survey

During the metamorphosing season (between April and September) of 2023 and 2024, we visited multiple locations with water bodies in Kanto region, Japan. Individuals that had recently undergone metamorphosis, specifically those with fully absorbed tails (Gosner’s stage 46; Gosner 1960) and found at the water's edge, were captured. We removed moisture from the specimens with paper towels and immediately weighed each individual on a handy scale (MS-50, CUSTOM, Japan) to the nearest 1 mg as size at metamorphosis. Following the completion of measurements, the individuals were promptly released back to their original locations.

Common garden experiment

We wrote about common garden method  in this file.
DOI: 10.25574/18941
title: Chandra X-ray Observatory ObsId 18941

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.5281/zenodo.15111704
title: Size at metamorphosis

description: We measured size at metamorphosis of Bufo japonicus in the field. We then examined evolutionary response by employing a common garden experiment.

Field survey

During the metamorphosing season (between April and September) of 2023 and 2024, we visited multiple locations with water bodies in Kanto region, Japan. Individuals that had recently undergone metamorphosis, specifically those with fully absorbed tails (Gosner’s stage 46; Gosner 1960) and found at the water's edge, were captured. We removed moisture from the specimens with paper towels and immediately weighed each individual on a handy scale (MS-50, CUSTOM, Japan) to the nearest 1 mg as size at metamorphosis. Following the completion of measurements, the individuals were promptly released back to their original locations.

Common garden experiment

We wrote about common garden method  in this file.
DOI: 10.5281/zenodo.15175611
title: Telomere-to-telomere genome assembly of Malus sieversii unveils structural and deleterious variations underlying apple domestication
DOI: 10.5281/zenodo.16245815
title: Telomere-to-telomere genome assembly of Malus sieversii unveils structural and deleterious variations underlying apple domestication
DOI: 10.25574/18942
title: Chandra X-ray Observatory ObsId 18942

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18943
title: Chandra X-ray Observatory ObsId 18943

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18944
title: Chandra X-ray Observatory ObsId 18944

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18945
title: Chandra X-ray Observatory ObsId 18945

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18946
title: Chandra X-ray Observatory ObsId 18946

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18947
title: Chandra X-ray Observatory ObsId 18947

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18948
title: Chandra X-ray Observatory ObsId 18948

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.6084/m9.figshare.30389452.v1
title: Data for figures, Santero et al 2026. "Electrifying light vehicles in the United States shows emission reduction potential for all vehicle types and powertrains". Communications Sustainability.

description: This dataset provides all the underlying data required to reproduce the figures reported in the article "Electrifying light vehicles in the United States shows emission reduction potential for all vehicle types and powertrains"
DOI: 10.25574/18949
title: Chandra X-ray Observatory ObsId 18949

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18950
title: Chandra X-ray Observatory ObsId 18950

description: Probing the Dynamo Mechanism in Fully Convective Stars
DOI: 10.25574/18952
title: Chandra X-ray Observatory ObsId 18952

description: Understanding Dust Production in Supergiant X-ray Binaries
DOI: 10.25574/18953
title: Chandra X-ray Observatory ObsId 18953

description: Understanding Dust Production in Supergiant X-ray Binaries
DOI: 10.25574/18954
title: Chandra X-ray Observatory ObsId 18954

description: Understanding Dust Production in Supergiant X-ray Binaries
DOI: 10.25574/18955
title: Chandra X-ray Observatory ObsId 18955

description: Tracking the Evolution of an X-ray Counterpart to a Gravitational Wave Event
DOI: 10.25574/18960
title: Chandra X-ray Observatory ObsId 18960

description: Precise Localization of Transient Low-Mass X-ray Binaries
DOI: 10.25574/18969
title: Chandra X-ray Observatory ObsId 18969

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18970
title: Chandra X-ray Observatory ObsId 18970

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.17026/ar/3xrtos
title: PAN-00099960 - coin/coin-related, Marcus Aurelius (161-180), voor Faustina II, sestertius

description: &lt;p&gt;This find is registered at Portable Antiquities of the Netherlands with number PAN-00099960&lt;/p&gt;
description: Modified: 2025-07-29T08:53:20+02:00
DOI: 10.25574/18971
title: Chandra X-ray Observatory ObsId 18971

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18972
title: Chandra X-ray Observatory ObsId 18972

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18973
title: Chandra X-ray Observatory ObsId 18973

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18974
title: Chandra X-ray Observatory ObsId 18974

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18975
title: Chandra X-ray Observatory ObsId 18975

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18976
title: Chandra X-ray Observatory ObsId 18976

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18977
title: Chandra X-ray Observatory ObsId 18977

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18978
title: Chandra X-ray Observatory ObsId 18978

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18979
title: Chandra X-ray Observatory ObsId 18979

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18980
title: Chandra X-ray Observatory ObsId 18980

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18981
title: Chandra X-ray Observatory ObsId 18981

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.16904/envidat.411
title: Avalanche accidents in Switzerland since 1970/71

description: **When using this data, please consider and adhere to the associated [Terms of Use](https://www.slf.ch/en/services-and-products/data-and-monitoring/slf-data-service.html)**.
Consider the newest version with the highest version number.
This data collection contains information concerning all known accidents by snow avalanches in Switzerland with at least one person involved (caught). The data set commences on 01/10/1970. After the completion of a hydrological year, the new data is added.
The following information is provided:
 * avalanche identifier 
 * date of the accident 
 * accuracy of the date in range of days before and after 
 * canton 
 * municipality 
 * start zone point latitude
 * start zone point longitude
 * start zone point accuracy (in meters)
 * start zone point elevation (in meteres above sea level) 
 * slope aspect (main orientation of start zone) 
 * slope inclination (in degree, steepest point within start zone) 
 * forecasted avalanche danger level 1 (first danger) 
 * forecasted avalanche danger level 2 (second danger)
 * accident within the core zone (most dangerous aspect and elevation as mentioned in the forecast) 
 * number of dead persons 
 * number of caught persons 
 * number of fully buried persons 
 * activity/location of the accident party at the time of the incident
description: Resource Title: avalanche_accidents_all_switzerland_since_1970.csv
 Size: 639529 bytes
 Format: application/vnd.ms-excel
 URL: https://www.envidat.ch/dataset/aa035efb-630a-4b7f-a406-f7a579a74de9/resource/9c1015af-0145-4ee8-968e-075158bc2228/download/avalanche_accidents_all_switzerland_since_1970.csv
 Description: avalanche_accidents_all_switzerland_since_1970.csv
description: Resource Title: version2_avalanche_accidents_all_switzerland_since_1970.csv
 Size: 614072 bytes
 Format: text/csv
 URL: https://www.envidat.ch/dataset/aa035efb-630a-4b7f-a406-f7a579a74de9/resource/944beac1-11d1-4c84-9bd9-683d12a3c581/download/version2_avalanche_accidents_all_switzerland_since_1970.csv
 Description:
DOI: 10.25574/18982
title: Chandra X-ray Observatory ObsId 18982

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18983
title: Chandra X-ray Observatory ObsId 18983

description: The Nature of INTEGRAL Sources in the Galactic Plane
DOI: 10.25574/18984
title: Chandra X-ray Observatory ObsId 18984

description: New progress in understanding the crusts of neutron stars