cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5064/f6vanjl8/nlxftw
title: Silan-Ciruelas_FRA_Opt1_22A_Hector_LGBT_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/0k4bpg
title: Silan-Ciruelas_PHL_Opt2_1A_Nica_1_Low_Low-Median.pdf
DOI: 10.5064/f6vanjl8/tlsm3q
title: Silan-Ciruelas_USA_Opt2_20B_Marina_20_High_Median-High.pdf
DOI: 10.5061/dryad.b9k42
title: Data from: Control of relative timing and stoichiometry by a master regulator

description: Developmental processes in cells require a series of complex steps. Often
 only a single master regulator activates genes in these different steps.
 This poses several challenges: some targets need to be ordered temporally,
 while co-functional targets may need to be synchronized in both time and
 expression level. Here we study in single cells the dynamic activation
 patterns of early meiosis genes in budding yeast, targets of the meiosis
 master regulator Ime1. We quantify the individual roles of the promoter
 and protein levels in expression pattern control, as well as the roles of
 individual promoter elements. We find a consistent expression pattern
 difference between a non-cofunctional pair of genes, and a highly
 synchronized activation of a co-functional pair. We show that dynamic
 control leading to these patterns is distributed between promoter, gene
 and external regions. Through specific reciprocal changes to the promoters
 of pairs of genes, we show that different genes can use different promoter
 elements to reach near identical activation patterns.
description: stat_files.tarQuantitative data for each of the experiments represented in Fig1 - Fig4 and FigS3. For each experiment, the data is generated by an image analysis pipeline run over the YFP,CFP and DIC image series, and presented in a matlab object, whose fields are described in the attached README file.abs_maxc_annotatedSource data for Fig. 4b, CFP part. The fields are described in the attached README file.abs_maxy_annotatedSource data for Fig. 4b, YFP part.
DOI: 10.5064/f6vanjl8/d7u3a7
title: Silan-Ciruelas_FRA_Opt1_24A_LGBT_High_Median-High.pdf
DOI: 10.5064/f6vanjl8/ovcowx
title: Silan-Ciruelas_USA_Opt1_6B_Jon_1-5_High_Low-Median.pdf
DOI: 10.5061/dryad.078nc
title: Data from: On the origin of mongrels: evolutionary history of free-breeding dogs in Eurasia

description: Although a large part of the global domestic dog population is
 free-ranging and free-breeding, knowledge of genetic diversity in these
 free-breeding dogs (FBDs) and their ancestry relations to pure-breed dogs
 is limited, and the indigenous status of FBDs in Asia is still uncertain.
 We analyse genome-wide SNP variability of FBDs across Eurasia, and show
 that they display weak genetic structure and are genetically distinct from
 pure-breed dogs rather than constituting an admixture of breeds. Our
 results suggest that modern European breeds originated locally from
 European FBDs. East Asian and Arctic breeds show closest affinity to East
 Asian FBDs, and they both represent the earliest branching lineages in the
 phylogeny of extant Eurasian dogs. Our biogeographic reconstruction of
 ancestral distributions indicates a gradual westward expansion of East
 Asian indigenous dogs to the Middle East and Europe through Central and
 West Asia, providing evidence for a major expansion that shaped the
 patterns of genetic differentiation in modern dogs. This expansion was
 probably secondary and could have led to the replacement of earlier
 resident populations in Western Eurasia. This could explain why earlier
 studies based on modern DNA suggest East Asia as the region of dog origin,
 while ancient DNA and archaeological data point to Western Eurasia.
description: SNP Database for Asian
 wolvesDatabase of SNP
 genotypes in PLINK format of 79 wolves sampled across
 AsiaAsian_wolves.pedA Map for Asian wolvesAsian_wolves.mapSNP Database for free-breeding and purebred dogsDatabase of SNP genotypes in PLINK of free-breeding and purebred dogs (plus 4 wolves from Nagorno-Karabakh)FBD_UK_database.pedA Map for free-breeding and purebred dogsFBD_UK_database.mapSample list for free-breeding and purebred dogsSample list.xlsx
DOI: 10.5064/f6vanjl8/z8xnmq
title: Silan-Ciruelas_USA_Opt2_22B_Marina_LGBTQ+AnyLength_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/wxjtul
title: Silan-Ciruelas_FRA_Opt1_15A_10-20_Low_Median-High.pdf
DOI: 10.5061/dryad.bm4nd
title: Data from: Genomic heterogeneity of historical gene flow between two species of newts inferred from transcriptome data

description: The role of gene flow in species formation is a major unresolved issue in
 speciation biology. Progress in this area requires information on the
 long-term patterns of gene flow between diverging species. Here, we used
 thousands of single-nucleotide polymorphisms derived from transcriptome
 resequencing and a method modeling the joint frequency spectrum of these
 polymorphisms to reconstruct patterns of historical gene flow between two
 Lissotriton newts: L. vulgaris (Lv) and L. montandoni (Lm). We tested
 several models of divergence including complete isolation and various
 scenarios of historical gene flow. The model of secondary contact received
 the highest support. According to this model, the species split from their
 common ancestor ca. 5.5 million years (MY) ago, evolved in isolation for
 ca. 2 MY, and have been exchanging genes for the last 3.5 MY Demographic
 changes have been inferred in both species, with the current effective
 population size of ca. 0.7 million in Lv and 0.2 million in Lm. The
 postdivergence gene flow resulted in two-directional introgression which
 affected the genomes of both species, but was more pronounced from Lv to
 Lm. Interestingly, we found evidence for genomic heterogeneity of
 interspecific gene flow. This study demonstrates the complexity of
 long-term gene flow between distinct but incompletely reproductively
 isolated taxa which divergence was initiated millions of years ago.
description: transcriptome-­based
 gene models (LmTGM)Transcriptome-­based
 gene models for Lissotriton montandoniLmTGM.fasta.gzL. vulgaris & L. montandoni SNPs (VCF format)Variant (SNP) data obtained by mapping (with bowtie2) 6 samples of Lissotriton montandoni (Lm) and 6 samples of Lissotriton vulgaris (Lv) to transcriptome-based gene models of Lm, and next by SNP calling process in Samtools. Data are in Variant Call Format (VCF).Lm_Lv.vcf.gz
DOI: 10.5064/f6vanjl8/ykmgyh
title: Silan-Ciruelas_BRA_Opt1_6B_Fernando_1-5_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/hkoagw
title: Silan-Ciruelas_PHL_Opt1_10B_Donn_5-10_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/p9nvi2
title: Silan-Ciruelas_TUR_Opt2_25B_Anil_Non-Monogamous.pdf
DOI: 10.5064/f6vanjl8/ikfod5
title: Silan-Ciruelas_FRA_Opt1_10B_5-10_Low_Low-Median.pdf
DOI: 10.5064/f6vanjl8/7whnxc
title: Silan-Ciruelas_PHL_Opt2-21A-Christelle_LGBTAnyLength_Low_Low-Median.pdf
DOI: 10.5061/dryad.138cg
title: Data from: Tracking marine mammals in 3D using electronic tag data

description: 1. Information about at-depth behaviour of marine mammals is fundamental
 yet very hard to obtain from direct visual observation. Animal-borne
 multisensor electronic tags provide a unique window of observation into
 such behaviours. 2. Electronic tag sensors allow the estimation of the
 animal's 3-dimensional (3D) orientation, depth and speed. Using tag
 flow noise level to provide an estimate of animal speed, we extend
 existing approaches of 3D track reconstruction by allowing the direction
 of movement to differ from that of the animal's longitudinal axis. 3.
 Data are processed by a hierarchical Bayesian model that allows processing
 of multisource data, accounting for measurement errors and testing
 hypotheses about animal movement by comparing models. 4. We illustrate the
 approach by reconstructing the 3D track of a 52-min deep dive of a
 Blainville's beaked whale Mesoplodon densirostris adult male fit with
 a digital tag (DTAG) in the Bahamas. At depth, the whale alternated
 regular movements at large speed (&gt;1·5 m s -1) and more complex
 movements at lower speed (&lt;1·5m s-1) with differences between
 movement and longitudinal axis directions of up to 28inline image. The
 reconstructed 3D track agrees closely with independent acoustic-based
 localizations. 5. The approach is potentially applicable to study the
 underwater behaviour (e.g. response to anthropogenic disturbances) of a
 wide variety of species of marine mammals fitted with triaxial
 magnetometer and accelerometer tags.
description: DTAG data (depth,
 accelerometer, magnetometer)DTAG data of a
 Blainville's beaked whale (Mesoplodon densirostris) deep dive, adult
 male tagged on the 5th September 2007 (tag on position: 24.3839 N, 77.5615
 W). Columns are time (in second), depth (in m), 3-axis accelerometer
 values (no unit), 3-axis magnetometer values (no unit). Accelerometer and
 magnetometer values are in the tag frame and were normalized with respect
 to the norm of the Earth gravitational and magnetic fields at the tag
 location. Data provided are at 5 Hz, the recording lasts 51'20, time
 in the table starts at tag-on (t=460 s; t=0 s in the
 paper).md07248b_depth_magnetometer_accelerometer_5Hz_from460to3540.csvDTAG data (acoustics)Acoustic DTAG data of a Blainville's beaked whale (Mesoplodon densirostris) deep dive, adult male tagged on the 5th September 2007 (tag on position: 24.3839 N, 77.5615 W). Data provided were downsampled at 24 kHz, mono, the recording lasts 51'20.md07248b_acoustics_mono_24kHz_from460to3540.wav
DOI: 10.5064/f6vanjl8/jpgsdf
title: Silan-Ciruelas_PHL_Opt1_5B_Christelle_1-5_Low_Low-Median.pdf
DOI: 10.5064/f6vanjl8/kwlr7r
title: Silan-Ciruelas_PHL_Opt2-7A-Christelle_1-5_Low_Median-High.pdf
DOI: 10.5064/f6vanjl8/8hre9u
title: Silan-Ciruelas_USA_Opt2_12A_Haley_5-10_High_Median-High.pdf
DOI: 10.5064/f6vanjl8/xue1wc
title: Silan-Ciruelas_PHL_Opt2-21B-Christelle_LGBTAnyLength_Low_Low-Median.pdf
DOI: 10.5061/dryad.vr57b
title: Data from: Spatiotemporal spike coding of behavioral adaptation in the dorsal anterior cingulate cortex

description: The frontal cortex controls behavioral adaptation in environments governed
 by complex rules. Many studies have established the relevance of firing
 rate modulation after informative events signaling whether and how to
 update the behavioral policy. However, whether the spatiotemporal features
 of these neuronal activities contribute to encoding imminent behavioral
 updates remains unclear. We investigated this issue in the dorsal anterior
 cingulate cortex (dACC) of monkeys while they adapted their behavior based
 on their memory of feedback from past choices. We analyzed spike trains of
 both single units and pairs of simultaneously recorded neurons using an
 algorithm that emulates different biologically plausible decoding
 circuits. This method permits the assessment of the performance of both
 spike-count and spike-timing sensitive decoders. In response to the
 feedback, single neurons emitted stereotypical spike trains whose temporal
 structure identified informative events with higher accuracy than mere
 spike count. The optimal decoding time scale was in the range of 70–200
 ms, which is significantly shorter than the memory time scale required by
 the behavioral task. Importantly, the temporal spiking patterns of single
 units were predictive of the monkeys’ behavioral response time.
 Furthermore, some features of these spiking patterns often varied between
 jointly recorded neurons. All together, our results suggest that dACC
 drives behavioral adaptation through complex spatiotemporal spike coding.
 They also indicate that downstream networks, which decode dACC feedback
 signals, are unlikely to act as mere neural integrators.
description: Spike sorted neuronal
 activity in relation to behavioral eventsMatlab data files. The
 description is in the main README file for the whole data
 Package.SpikingData.tarMatlab script for computing the normalized spike train distanceThe function takes as an input the spike times of the two spike trains and the Victor and Purpura cost, and returns the normalized distance (that we developed for the analysis linking neuronal activity to behavior).compute_normalized_dist.mEye position (in X and Y) for monkey M in the available sessionsFor monkey M, during the sessions for which they were recorded, the X and Y position of the eye in relation to the behavioral task. The description of the file is in the main README file.EOGData.tarREADMEDetailed explanation for all the files provided.
DOI: 10.5064/f6vanjl8/5scyxa
title: Silan-Ciruelas_FRA_Opt1_4B_Hector_1_5_High_Median-High.pdf
DOI: 10.5064/f6vanjl8/dwvyrv
title: Silan-Ciruelas_FRA_Opt1_12B_5-10_High_Median-High.pdf
DOI: 10.5064/f6vanjl8/cknpbp
title: Silan-Ciruelas_FRA_Opt1_7B_1_5_Low_Median_High.pdf
DOI: 10.5064/f6vanjl8/mlbgeb
title: Silan-Ciruelas_BRA_Opt2_8B_Fernando_1-5_High_Median-High.pdf
DOI: 10.5064/f6vanjl8/odlgdq
title: Silan-Ciruelas_PHL_Opt2_25B_Rozel_NonMonogamous_Any.pdf
DOI: 10.5064/f6vanjl8/wdypks
title: Silan-Ciruelas_USA_Opt2_5A_AnaliliaReglaGutierrez_1-5_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/oatfl6
title: Silan-Ciruelas_Opt1_Therapist1.pdf
DOI: 10.5064/f6vanjl8/nx0w1t
title: Silan-Ciruelas_USA_Opt2_14B_Haley_5-10_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/qlq4xj
title: Silan-Ciruelas_USA_Opt2_3B_Silky_1_Low_Median-High.pdf
DOI: 10.5061/dryad.1k7d35q
title: Data from: Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP)

description: Objective: To characterize peri-ictal apnea and post-ictal asystole in
 generalized convulsive seizures (GCS) of intractable epilepsy. Methods:
 Prospective, multi-center epilepsy monitoring study of autonomic and
 breathing biomarkers of SUDEP in patient’s ≥18 years old with intractable
 epilepsy and monitored GCS. Video EEG, thoraco-abdominal excursions, nasal
 airflow, capillary oxygen saturation and electrocardiography were
 analyzed. Results: We studied 148 GCS in 87 patients. Nineteen patients
 had generalized epilepsy, 65 had focal, one had both and in two, the
 epileptogenic zone was unknown. Ictal central apnea (ICA) preceded GCS in
 49/121 (40.4%) seizures in 23 patients, all with focal epilepsy.
 Post-convulsive central apnea (PCCA) occurred in 31/140 (22.1%) seizures
 in 22 patients, with generalized, focal or unknown epileptogenic zones. In
 two patients, PCCA occurred concurrently with asystole (near-SUDEP), with
 an incidence rate of 10.2/1000 patient-years. One PCCA patient died of
 probable SUDEP during follow up, suggesting a SUDEP incidence rate 5.1 per
 1000 patient-years. No cases of laryngospasm were detected. Rhythmical
 muscle artifact synchronous with breathing was present in 75/147 seizures,
 and related to stertorous breathing (OR 3.856, 95%CI 1.395-10.663,
 p=0.009). Conclusions: PCCA occurred in both focal and generalized
 epilepsies, suggesting a different pathophysiology from ICA, which only
 occurred in focal epilepsy. PCCA was seen in two near-SUDEP and one
 probable SUDEP case, suggesting that this phenomenon may serve as a
 clinical biomarker of SUDEP. Larger studies are needed to validate this
 observation. Rhythmical post-ictal muscle artifact is suggestive of
 post-GCS breathing effort, rather than a specific biomarker of
 laryngospasm.
description: Supplementary
 materialSupplementary tables (E-
 tables 1, 2, 3)Near-SUDEP Event in
 Patient 1Video
 1Video
 1.mp4Near-SUDEP Event in
 Patient 2Video
 2.mp4Legend for the
 videosDescription of videos 1
 and 2
DOI: 10.5064/f6vanjl8/fquvjk
title: Silan-Ciruelas_BRA_Opt2_6A_Fernando_1-5_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/j63hg0
title: Silan-Ciruelas_ManyQuali_Collaborators.xlsx
DOI: 10.5061/dryad.cq183
title: Data from: A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa

description: One in three people has been infected with Mycobacterium tuberculosis
 (MTB), and the risk for MTB infection in HIV-infected individuals is even
 higher. We hypothesized that HIV-positive individuals living in
 tuberculosis-endemic regions who do not get infected by Mycobacterium
 tuberculosis are genetically resistant. Using an "experiment of
 nature" design that proved successful in our previous work, we
 performed a genome-wide association study of tuberculin skin test
 positivity using 469 HIV-positive patients from prospective study cohorts
 of tuberculosis from Tanzania and Uganda to identify genetic loci
 associated with MTB infection in the context of HIV-infection. Among these
 individuals, 244 tested were tuberculin skin test (TST) positive either at
 enrollment or during the &gt;8 year follow up, while 225 were not. We
 identified a genome-wide significant association between the dominant
 model of rs877356 and binary TST status in the combined cohort (OR=0.2671,
 p=1.22x10-8). Association was replicated with similar significance when
 examining TST induration as a continuous trait. The variant lies in the
 5q31.1 region, 57kb downstream from IL9. Two-locus analyses of association
 of variants near rs877356 showed a haplotype comprised of rs877356 and an
 IL9 missense variant rs2069885 had the most significant association
 (p=1.59x10-12). We also replicated previously linked loci on chromosomes
 2, 5, and 11. IL9 is a cytokine produced by mast cells and T¬H2 cells
 during inflammatory responses, providing a possible link between airway
 inflammation and protection from MTB infection. Our results indicate that
 studying uninfected participants with extensive exposure increases the
 power to detect associations in complex infectious disease.
description: Key to
 filesDescription of all files
 for this paperLegend for summary
 statistic filesCombined TZ UG dominant
 model MAF above 05Summary results for all
 analyzed SNPs in combined analysesTZ dominant model MAF
 above 05Tanzania summary
 resultsUG dominant model MAF
 above 05Summary statistics for
 Uganda samplestanzanian map
 filetanzanian ped
 file
DOI: 10.5064/f6vanjl8/gjhrgj
title: Silan-Ciruelas_DemographicDetails.tab
DOI: 10.5064/f6vanjl8/pqctrx
title: Silan-Ciruelas_BRA_Opt2_15A_10_20_Low_Median-High.pdf
DOI: 10.5061/dryad.2tp56
title: Data from: High-frequency resonance in the gerbil medial superior olive

description: A high-frequency, subthreshold resonance in the guinea pig medial superior
 olive (MSO) was recently linked to the efficient extraction of spatial
 cues from the fine structure of acoustic stimuli. We report here that MSO
 neurons in gerbil also have resonant properties and, based on our
 whole-cell recordings and computational modeling, that a low-voltage-gated
 potassium current, IKLT, underlies the resonance. We show that resonance
 was lost following dynamic clamp replacement of IKLT with a leak
 conductance and in the model when voltage-gating of IKLT was suppressed.
 Resonance was characterized using small amplitude sinusoidal stimuli to
 generate impedance curves as typically done for linear systems analysis.
 Extending our study into the nonlinear, voltage-dependent regime, we
 increased stimulus amplitude and found, experimentally and in simulations,
 that the subthreshold resonant frequency (242Hz for weak stimuli)
 increased continuously to the resonant frequency for spiking (285Hz). The
 spike resonance of these phasic-firing (type III excitable) MSO neurons
 and of the model is of particular interest also because previous studies
 of resonance typically involved neurons/models (type II excitable, such as
 the standard Hodgkin-Huxley model) that can fire tonically for steady
 inputs. To probe more directly how these resonances relate to MSO neurons
 as slope-detectors, we presented periodic trains of brief, fast-rising
 excitatory post-synaptic potentials (EPSCs) to the model. While weak
 subthreshold EPSC trains were essentially low-pass filtered, resonance
 emerged as EPSC amplitude increased. Interestingly, for spike-evoking EPSC
 trains, the threshold amplitude at spike resonant frequency (317Hz) was
 lower than the single ESPC threshold. Our finding of a frequency-dependent
 threshold for repetitive brief EPSC stimuli and preferred frequency for
 spiking calls for further consideration of both subthreshold and
 suprathreshold resonance to fast and precise temporal processing in the
 MSO.
description: drive-download-20161008T232841ZAugust - December 2014drive-download-20161008T233312ZJanuary - April 2015
DOI: 10.5064/f6vanjl8/cqzls0
title: Silan-Ciruelas_TUR_Opt1_2B_Sinem_1_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/dnulgu
title: Silan-Ciruelas_TUR_Opt2_17B_Kerem_Over20_Low_Low-Median.pdf
DOI: 10.5064/f6vanjl8/o79vyi
title: Silan-Ciruelas_FRA_Opt1_18A_20+_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/3vixia
title: Silan-Ciruelas_Opt2_Therapist18.pdf
DOI: 10.5064/f6vanjl8/q7ojpd
title: Silan-Ciruelas_USA_Opt1_16A_Jon_10-20_High_Median-High.pdf
DOI: 10.5061/dryad.78ng1
title: Data from: Development of genomic tools in a widespread tropical tree, Symphonia globulifera L.f.: a new low-coverage draft genome, SNP and SSR markers

description: Population genetic studies in tropical plants are often challenging
 because of limited information on taxonomy, phylogenetic relationships and
 distribution ranges, scarce genomic information and logistic challenges in
 sampling. We describe a strategy to develop robust and widely applicable
 genetic markers based on a modest development of genomic resources in the
 ancient tropical tree species Symphonia globulifera L.f. (Clusiaceae), a
 keystone species in African and Neotropical rainforests. We provide the
 first low-coverage (11X) fragmented draft genome sequenced on an
 individual from Cameroon, covering 1.027 Gbp or 67.5% of the estimated
 genome size. Annotation of 565 scaffolds (7.57 Mbp) resulted in the
 prediction of 1046 putative genes (231 of them containing a complete open
 reading frame) and 1523 exact simple sequence repeats (SSRs,
 microsatellites). Aligning a published transcriptome of a French Guiana
 population against this draft genome produced 923 high-quality single
 nucleotide polymorphisms. We also preselected genic SSRs in silico that
 were conserved and polymorphic across a wide geographical range, thus
 reducing marker development tests on rare DNA samples. Of 23 SSRs tested,
 19 amplified and 18 were successfully genotyped in four S. globulifera
 populations from South America (Brazil and French Guiana) and Africa
 (Cameroon and São Tomé island, FST = 0.34). Most loci showed only
 population-specific deviations from Hardy–Weinberg proportions, pointing
 to local population effects (e.g. null alleles). The described genomic
 resources are valuable for evolutionary studies in Symphonia and for
 comparative studies in plants. The methods are especially interesting for
 widespread tropical or endangered taxa with limited DNA availability.
description: Symphonia globulifera 18
 SSRs in 4 populations, Spagedi formatSymphonia globulifera
 data at 18 SSR markers in four populations, in the format of Spagedi
 software (http://ebe.ulb.ac.be/ebe/SPAGeDi.html). Line 1: total number of
 individuals (125), number of populations (4), number of geographic
 coordinates (0), number of loci (18), number of digits per allele (3),
 ploidy (2). Line 2: number of distance classes (0). Line 3: column headers
 for rows below, including the sample identification (ID), population name
 (Place) and locus numbers. Following lines: ID of each sample, population
 of each sample (Itubera [Ituberá, Brazil], Nkong [Nkong Mekak, Cameroon],
 Sao_Tome [Sao Tomé island], Paracoug [morphotype S. globulifera in
 Paracou, French Guiana], Paracou1 [morphotype Symphonia sp.1 in Paracou,
 French Guiana]), SSR genotype at each locus coded by concatenation of the
 two alleles using 3 digits for each allele. Last line: END, to signal end
 of file.Sglo18+morphotypes.txtSymphonia globulifera genome draft in fasta format, zip compressedSymphonia globulifera L.f. genome draft in fasta format, zip compressed. Final contigs and scaffolds.symph_genome.zip
DOI: 10.5064/f6vanjl8/olu9gf
title: Silan-Ciruelas_PHL_Opt2_6A_Nica_1-5_High_Low-Median.pdf
DOI: 10.5064/f6vanjl8/zxov2r
title: Silan-Ciruelas_TUR_Opt2_11B_Sinem_5-10_Low_Median-High.pdf