cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.3710389
title: Dataset related to article "Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation."

description: BACKGROUND: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little insight exists on other immune subsets involved in the cardiotoxic response. METHODS: Here, we used single-cell RNA sequencing to map the cardiac immune composition in the standard murine nonischemic, pressure-overload heart failure model. By focusing our analysis on CD45<sup>+</sup> cells, we obtained a higher resolution identification of the immune cell subsets in the heart, at early and late stages of disease and in controls. We then integrated our findings using multiparameter flow cytometry, immunohistochemistry, and tissue clarification immunofluorescence in mouse and human. RESULTS: We found that most major immune cell subpopulations, including macrophages, B cells, T cells and regulatory T cells, dendritic cells, Natural Killer cells, neutrophils, and mast cells are present in both healthy and diseased hearts. Most cell subsets are found within the myocardium, whereas mast cells are found also in the epicardium. Upon induction of pressure overload, immune activation occurs across the entire range of immune cell types. Activation led to upregulation of key subset-specific molecules, such as oncostatin M in proinflammatory macrophages and PD-1 in regulatory T cells, that may help explain clinical findings such as the refractivity of patients with heart failure to anti-tumor necrosis factor therapy and cardiac toxicity during anti-PD-1 cancer immunotherapy, respectively. CONCLUSIONS: Despite the absence of infectious agents or an autoimmune trigger, induction of disease leads to immune activation that involves far more cell types than previously thought, including neutrophils, B cells, Natural Killer cells, and mast cells. This opens up the field of cardioimmunology to further investigation by using toolkits that have already been developed to study the aforementioned immune subsets. The subset-specific molecules that mediate their activation may thus become useful targets for the diagnostics or therapy of heart failure. This dataset is created in .ets form, we attach a pdf with the information about.
DOI: 10.5281/zenodo.3710388
title: Dataset related to article "Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation."

description: BACKGROUND: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little insight exists on other immune subsets involved in the cardiotoxic response. METHODS: Here, we used single-cell RNA sequencing to map the cardiac immune composition in the standard murine nonischemic, pressure-overload heart failure model. By focusing our analysis on CD45<sup>+</sup> cells, we obtained a higher resolution identification of the immune cell subsets in the heart, at early and late stages of disease and in controls. We then integrated our findings using multiparameter flow cytometry, immunohistochemistry, and tissue clarification immunofluorescence in mouse and human. RESULTS: We found that most major immune cell subpopulations, including macrophages, B cells, T cells and regulatory T cells, dendritic cells, Natural Killer cells, neutrophils, and mast cells are present in both healthy and diseased hearts. Most cell subsets are found within the myocardium, whereas mast cells are found also in the epicardium. Upon induction of pressure overload, immune activation occurs across the entire range of immune cell types. Activation led to upregulation of key subset-specific molecules, such as oncostatin M in proinflammatory macrophages and PD-1 in regulatory T cells, that may help explain clinical findings such as the refractivity of patients with heart failure to anti-tumor necrosis factor therapy and cardiac toxicity during anti-PD-1 cancer immunotherapy, respectively. CONCLUSIONS: Despite the absence of infectious agents or an autoimmune trigger, induction of disease leads to immune activation that involves far more cell types than previously thought, including neutrophils, B cells, Natural Killer cells, and mast cells. This opens up the field of cardioimmunology to further investigation by using toolkits that have already been developed to study the aforementioned immune subsets. The subset-specific molecules that mediate their activation may thus become useful targets for the diagnostics or therapy of heart failure. This dataset is created in .ets form, we attach a pdf with the information about.
DOI: 10.25919/5e6c45a886bc7
title: Parkes observations for project P1032 semester 2019OCTS_14

description: We propose timing observations of southern double neutron star (DNS) systems to obtain precise estimates of the component masses and thus increase the statistics of neutron star mass distribution. The improved sensitivity of the Ultra Wideband Low (UWL) receiver will provide a 3X increase in the precision of the time of arrivals (ToAs) of the pulses compared to the multibeam data. This has the potential to perform quick measurements of masses for a number of binary systems in the next 1-2 years. We will also use MeerKAT observations at crucial orbital phases to increase our chances of mass measurements. Increase in the number of measured NS masses has significant implications for understanding NS internal structure and for stellar and binary evolution physics.
DOI: 10.5281/zenodo.3710473
title: Deleted

description: Deleted
DOI: 10.5281/zenodo.3710472
title: Deleted

description: Deleted
DOI: 10.17632/pzrj6rn5hm.1
title: Data for: Repeated Resurgence with and without a Context Change

description: Data are organized by three consecutive phases that are repeated. Reinforcement schedules used are variable ratio and variable interval, separated by tabs. Target and alternative responding, as well as obtained reinforcer rates, are also in separate tabs. Each reinforcement-schedule type had two groups, AAA-AAA and AAA-BBB.
DOI: 10.21227/dxh0-hn41
title: Enterprise Master Data Hub Architecture

description: Master data has played a significant role in improving operational efficiencies and has attracted the attention of many large businesses over the decade. Recent professional searches have also proved a significant growth in the practice and research of managing these master data assets.Master data governance and management are technology-enabled practices for data quality, data management, business process management, and risk management through which businesses oversee master data assets and ensure the accuracy and accountability of the enterprise’s shared data. Enterprise MDM calls for the use of centralized governance and collaboration, also called the master data HUB system. Focusing on solutions to conceptual and real-world obstacles and enhancing the management process can contribute to deepening its applications and creating secure and profitable entrepreneurial communities.
DOI: 10.21227/t19g-ng43
title: Enterprise Master Data Hub Architecture

description: Master data has played a significant role in improving operational efficiencies and has attracted the attention of many large businesses over the decade. Recent professional searches have also proved a significant growth in the practice and research of managing these master data assets.Master data governance and management are technology-enabled practices for data quality, data management, business process management, and risk management through which businesses oversee master data assets and ensure the accuracy and accountability of the enterprise’s shared data. Enterprise MDM calls for the use of centralized governance and collaboration, also called the master data HUB system. Focusing on solutions to conceptual and real-world obstacles and enhancing the management process can contribute to deepening its applications and creating secure and profitable entrepreneurial communities.
DOI: 10.25919/5e6c4a8482b0e
title: Parkes observations for project P958 semester 2019OCTS_70

description: Fast radio bursts (FRBs) continue to raise more questions than they answer. Until last year, only one burst – the only one known to repeat - had been localized to a bright radio nebula (either a young supernova remnant or pulsar wind nebulae) in a distant dwarf galaxy. Over the last two year searches with the Australian Square Kilometre Array Pathfinder (ASKAP) have detected 31 bursts, five of which have been localised to host galaxies at redshifts ranging from 0.1 to 0.5. These bursts and their hosts are very unlike the repeater, suggesting there may be a dichotomy in the population. However one of the arcminute-localised ASKAP FRBs has recently been found to repeat. Here we propose to search and study repetitions in this FRB population. Our comprehensive sample and a dense monitoring campaign of well localised bursts, at a fluence limit more than 60 times lower than that of their detections to characterise the fraction of bursts that repeat. For bursts that repeat the unique wide bandwidth observations will be used to test leading models of burst emission.
DOI: 10.5281/zenodo.3710517
title: SAGE II version 7.0 ozone data (NetCDF)

description: SAGE II ozone and line-of-sight optical depth data. This is a subset of the SAGE II version 7.0 data set available from https://eosweb.larc.nasa.gov/project/sage2/sage2_v7_table in NetCDF format. Note that no screening of the data has been performed.
description: The full data set of SAGE II version 7.0 data are publicly available at https://eosweb.larc.nasa.gov/project/sage2/sage2_v7_table, doi:10.5067/ERBS/SAGEII/SOLAR_BINARY_L2-V7.0.
description: {"references": ["SAGE II Science Team (2012), SAGE II Version 7.00 Data, Hampton, VA, USA: NASA Atmospheric Science Data Center (ASDC), Accessed Jan 2019 at doi: 10.5067/ERBS/SAGEII/SOLAR_BINARY_L2-V7.0", "Damadeo, R. P., Zawodny, J. M., Thomason, L. W., and Iyer, N.: SAGE version 7.0 algorithm: application to SAGE II, Atmospheric Measurement Techniques, 6, 3539\u20133561, https://doi.org/10.5194/amt-6-3539-2013, 2013."]}
DOI: 10.21227/9kbq-1753
title: Corona Virus (COVID-19) Tweets Dataset

description: Tweets Counter: 9.1 Million plus (collecting since Feb 1, 2020)Each database (*.db) contain three columns.First column: date and time of the tweetSecond column: tweetThird column: sentiment score for the particular tweet within the range [-1,1] with -1 being the most negative, 0 being the neutral and +1 being the most positive sentiment.The tweets have been collected by the LSTM model deployed here at sentiment.live.To make it easy for the NLP researchers to get access to the sentiment analysis of each collected tweet, the sentiment score out of TextBlob [2] has been appended as the last column. New databases will be added to this dataset every week. Bookmark this page for further updates. [1] https://sentiment.live/ [2] https://textblob.readthedocs.io/en/dev/
DOI: 10.21227/dbx9-wk57
title: Corona Virus (COVID-19) Tweets Dataset

description: Tweets Counter: 3.8 Million plus (collecting since Feb 1, 2020)Each database (*.db) contain three columns.First column: date and time of the tweetSecond column: tweetThird column: sentiment score for the particular tweet within the range [-1,1] with -1 being the most negative, 0 being the neutral and +1 being the most positive sentiment.The tweets have been collected by the LSTM model deployed here at sentiment.live.To make it easy for the NLP researchers to get access to the sentiment analysis of each collected tweet, the sentiment score out of TextBlob [2] has been appended as the last column. New databases will be added to this dataset every week. Bookmark this page for further updates. [1] https://sentiment.live/ [2] https://textblob.readthedocs.io/en/dev/
DOI: 10.21227/rgfp-bq52
title: Corona Virus (COVID-19) Tweets Dataset

description: Tweets Counter: 3.8 Million plus (collecting since Feb 1, 2020)Each database (*.db) contain three columns.First column: date and time of the tweetSecond column: tweetThird column: sentiment score for the particular tweet within the range [-1,1] with -1 being the most negative, 0 being the neutral and +1 being the most positive sentiment.The tweets have been collected by the LSTM model deployed here at sentiment.live.To make it easy for the NLP researchers to get access to the sentiment analysis of each collected tweet, the sentiment score out of TextBlob [2] has been appended as the last column. New databases will be added to this dataset every week. Bookmark this page for further updates. [1] https://sentiment.live/ [2] https://textblob.readthedocs.io/en/dev/
DOI: 10.5519/qd.tttfvdag
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1222 records)
DOI: 10.5281/zenodo.3710700
title: Dataset related to the article "S-ICD is effective in preventing sudden death in arrhythmogenic cardiomyopathy athletes during exercise"

description: This record contains raw data related to the article “S-ICD is effective in preventing sudden death in arrhythmogenic cardiomyopathy athletes during exercise”. Abstract Here, we describe the cases of two elite athletes, with a diagnosis of arrhythmogenic cardiomyopathy (ACM), in which a subcutaneous implantable cardioverter defibrillator (S-ICD) has been implanted. Both patients experienced a ventricular tachycardia during exercise and received effective S-ICD shocks that interrupted arrhythmias. This report reveals for the first time that the S-ICD is effective in reverting arrhythmias in ACM patients, even during exercise. Moreover, these cases may confirm that competition/physical activity is associated with ICD shocks.
DOI: 10.5281/zenodo.3710701
title: Dataset related to the article "S-ICD is effective in preventing sudden death in arrhythmogenic cardiomyopathy athletes during exercise"

description: This record contains raw data related to the article “S-ICD is effective in preventing sudden death in arrhythmogenic cardiomyopathy athletes during exercise”. Abstract Here, we describe the cases of two elite athletes, with a diagnosis of arrhythmogenic cardiomyopathy (ACM), in which a subcutaneous implantable cardioverter defibrillator (S-ICD) has been implanted. Both patients experienced a ventricular tachycardia during exercise and received effective S-ICD shocks that interrupted arrhythmias. This report reveals for the first time that the S-ICD is effective in reverting arrhythmias in ACM patients, even during exercise. Moreover, these cases may confirm that competition/physical activity is associated with ICD shocks.
DOI: 10.5281/zenodo.3710690
title: The Unified Phenotype Ontology (uPheno) - Version 2, Alpha release

description: This is the Alpha release of the re-designed Unified Phenotype Ontology (uPheno), referred to internally as uPheno 2. The effort responsible for the content of uPheno 2 is the Phenotype Reconciliation Effort. The pipeline that generates uPheno 2 can be found here: https://github.com/obophenotype/upheno-dev.
description: This work was funded by an NIH grant to the Monarch Initiative (https://monarchinitiative.org/).
DOI: 10.5281/zenodo.3710689
title: The Unified Phenotype Ontology (uPheno) - Version 2, Alpha release

description: This is the Alpha release of the re-designed Unified Phenotype Ontology (uPheno), referred to internally as uPheno 2. The effort responsible for the content of uPheno 2 is the Phenotype Reconciliation Effort. The pipeline that generates uPheno 2 can be found here: https://github.com/obophenotype/upheno-dev.
description: This work was funded by an NIH grant to the Monarch Initiative (https://monarchinitiative.org/).
DOI: 10.5281/zenodo.3710721
title: Dataset related to the article "Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid"

description: This record contains raw data related to the article “Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid" <strong>Abstract</strong> Given to its ability to irreversibly acetylate the platelet cyclooxygenase-1 enzyme, acetylsalicylic acid (ASA) is successfully employed for the prevention of cardiovascular disease. Recently, an antitumoral effect of ASA in colorectal cancer has been increasingly documented. However, the molecular and metabolic mechanisms by which ASA exerts such effect is largely unknown. Using a new, untargeted liquid chromatography-mass spectrometry approach, we have analyzed urine samples from seven healthy participants that each ingested 100 mg of ASA once daily for 1 week. Of the 2007 features detected, 25 metabolites differing after ASA ingestion (nominal <em>p</em> &lt; 0.05 and variable importance in projection (VIP) score &gt; 1) were identified, and pathway analysis revealed low levels of glutamine and of metabolites involved in histidine and purine metabolisms. Likewise, consistent with an altered fatty acid <em>β</em>-oxidation process, a decrease in several short- and medium-chain acyl-carnitines was observed. An abnormal <em>β</em>-oxidation and a lower than normal glutamine availability suggests reduced synthesis of acetyl-Co-A, as they are events linked to one another and experimentally related to ASA antiproliferative effects. While giving an example of how untargeted metabolomics allows us to explore new clinical applications of drugs, the present data provide a direction to be pursued to test the therapeutic effects of ASA-e.g., the antitumoral effect-beyond cardiovascular protection.
description: This research was funded by Italian Ministry of Health (grant number RC-2015 BIO05 id2617742)
DOI: 10.5281/zenodo.3710720
title: Dataset related to the article "Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid"

description: This record contains raw data related to the article “Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid" <strong>Abstract</strong> Given to its ability to irreversibly acetylate the platelet cyclooxygenase-1 enzyme, acetylsalicylic acid (ASA) is successfully employed for the prevention of cardiovascular disease. Recently, an antitumoral effect of ASA in colorectal cancer has been increasingly documented. However, the molecular and metabolic mechanisms by which ASA exerts such effect is largely unknown. Using a new, untargeted liquid chromatography-mass spectrometry approach, we have analyzed urine samples from seven healthy participants that each ingested 100 mg of ASA once daily for 1 week. Of the 2007 features detected, 25 metabolites differing after ASA ingestion (nominal <em>p</em> &lt; 0.05 and variable importance in projection (VIP) score &gt; 1) were identified, and pathway analysis revealed low levels of glutamine and of metabolites involved in histidine and purine metabolisms. Likewise, consistent with an altered fatty acid <em>β</em>-oxidation process, a decrease in several short- and medium-chain acyl-carnitines was observed. An abnormal <em>β</em>-oxidation and a lower than normal glutamine availability suggests reduced synthesis of acetyl-Co-A, as they are events linked to one another and experimentally related to ASA antiproliferative effects. While giving an example of how untargeted metabolomics allows us to explore new clinical applications of drugs, the present data provide a direction to be pursued to test the therapeutic effects of ASA-e.g., the antitumoral effect-beyond cardiovascular protection.
description: This research was funded by Italian Ministry of Health (grant number RC-2015 BIO05 id2617742)
DOI: 10.5281/zenodo.3710716
title: Dataset related to the article "Characterization of aspirin esterase activity in health and disease: in vitro and ex vivo studies"

description: This record contains raw data related to the article “Characterization of aspirin esterase activity in health and disease: In vitro and ex vivo studies" ABSTRACT Due to its ability to irreversibly inactivate platelet cyclooxygenase, low-dose aspirin (ASA) is the most widely used antithrombotic agent. Although, studies in specific types of patients with cardiovascular disease (CVD) have shown an incomplete inhibition of platelet’s cyclooxygenase, which may increase the variability in drug response. Some aspects of ASA pharmacokinetics (PK) still need further investigation. In this study, we aimed to characterise the contribution of esterase enzymes to ASA hydrolysis in the peripheral blood and to assess their activity in 36 healthy subjects (Ctrl) and 77 CVD patients. To this aim, an in vitro assay testing esterase activity in parallel to a liquid chromatography-tandem mass spectrometry method simultaneously detecting ASA and its main metabolites salicylic (SA) and gentisic acids, have been developed. Michaelis-Menten constant (Km) calculation, ASA esterase isoforms characterisation, and ASA PK study were then achieved. The calculated Km identified plasma esterases as the enzymes with the higher affinity for the substrate compared to the RBC ones. Both rivastigmine and 4-bis-nitrophenyl phosphate inhibited plasma esterase activities, suggesting that acetylcholinesterase and carboxylesterase largely contribute to ASA hydrolysis. The feasibility of the method here developed has been explored in Ctrl and CVD patients. The effect of ASA treatment on enzyme activity was further evaluated on an age, sex and BMI matched subgroup of patients and Ctrl (n = 10 for each subgroup, on and off ASA). No overall variations were evidenced in both CVD and Ctrl groups, even when the effect of ASA treatment was tested. This result suggests the absence of any influence of disease state, drug treatments, and comorbidities on plasma esterase and the inability of ASA intake to induce esterase function. In conclusion, the method here developed allows a better characterisation of ASA esterase activity and could be helpful to define the PK-related determinants of ASA responsiveness in order to personalise regimen in specific pathological conditions.
description: This work was supported by the Italian Ministry of Health, Rome, Italy (Ricerca Corrente 2013 BIO 05 n° 2600896; 2014 BIO 05 n°2607490; 2015 BIO 05 n° 2617742)