cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17141951
title: Supplementary Material for: Retrospective Database Analysis: Dose Escalation and Adherence in Patients Initiating Biologics for Ulcerative Colitis

description: Background: Biologic therapies are often used in patients with ulcerative colitis who are non-responsive to conventional treatments. However, non-response or loss of response to biologics often occurs, leading to dose escalation, combination therapy, and/or treatment switching. We investigated real-world treatment patterns of biologic therapies among patients with ulcerative colitis in the USA. Methods: This study analyzed data from the IBM® MarketScan® Commercial and Medicare Supplemental Databases (medical/pharmacy claims for &gt;250 million patients in the USA) to identify patients with ulcerative colitis initiating a biologic therapy (adalimumab, infliximab, golimumab, or vedolizumab) with 12 months of follow-up post-initiation. Key measures were patient baseline characteristics, dose escalation (average maintenance dose &gt;20% higher than label), adherence (proportion of days covered), and ulcerative colitis-related healthcare costs in the 12 months following biologic therapy initiation. Results: Of 2,331 patients included in the study (adalimumab [N=1,291], infliximab [N=810], golimumab [N=127], vedolizumab [N=103]), 28.1% used concomitant immunosuppressant therapy within 12 months post-initiation. Overall, 23.6% (adalimumab), 34.8% (infliximab), 9.9% (golimumab), and 39.2% (vedolizumab) of patients dose escalated within 12 months. Patients who dose escalated incurred $20,106 higher total ulcerative colitis-related healthcare costs over 12 months than those who did not. Adherence (covariate-adjusted proportion of days covered) ranged from 0.63 to 0.73, and 39.3% of patients discontinued within 12 months (median treatment duration=112 days). Conclusion: Dose escalation was common, and incurred higher costs, in patients with ulcerative colitis initiating biologic therapies. Sub-optimal adherence and/or discontinuation within 12 months of initiation occurred frequently, highlighting the challenges in managing these patients.
DOI: 10.6084/m9.figshare.17141951.v1
title: Supplementary Material for: Retrospective Database Analysis: Dose Escalation and Adherence in Patients Initiating Biologics for Ulcerative Colitis

description: Background: Biologic therapies are often used in patients with ulcerative colitis who are non-responsive to conventional treatments. However, non-response or loss of response to biologics often occurs, leading to dose escalation, combination therapy, and/or treatment switching. We investigated real-world treatment patterns of biologic therapies among patients with ulcerative colitis in the USA. Methods: This study analyzed data from the IBM® MarketScan® Commercial and Medicare Supplemental Databases (medical/pharmacy claims for &gt;250 million patients in the USA) to identify patients with ulcerative colitis initiating a biologic therapy (adalimumab, infliximab, golimumab, or vedolizumab) with 12 months of follow-up post-initiation. Key measures were patient baseline characteristics, dose escalation (average maintenance dose &gt;20% higher than label), adherence (proportion of days covered), and ulcerative colitis-related healthcare costs in the 12 months following biologic therapy initiation. Results: Of 2,331 patients included in the study (adalimumab [N=1,291], infliximab [N=810], golimumab [N=127], vedolizumab [N=103]), 28.1% used concomitant immunosuppressant therapy within 12 months post-initiation. Overall, 23.6% (adalimumab), 34.8% (infliximab), 9.9% (golimumab), and 39.2% (vedolizumab) of patients dose escalated within 12 months. Patients who dose escalated incurred $20,106 higher total ulcerative colitis-related healthcare costs over 12 months than those who did not. Adherence (covariate-adjusted proportion of days covered) ranged from 0.63 to 0.73, and 39.3% of patients discontinued within 12 months (median treatment duration=112 days). Conclusion: Dose escalation was common, and incurred higher costs, in patients with ulcerative colitis initiating biologic therapies. Sub-optimal adherence and/or discontinuation within 12 months of initiation occurred frequently, highlighting the challenges in managing these patients.
DOI: 10.48370/ofd/lgsiu7
title: Peniophora incarnata (Pers.) P. Karst, 1157

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.19070273
title: The transition from invariant to action-dependent visual object representation in human dorsal pathway

description: Experimental stimuli. fMRI data. analysis results.
DOI: 10.6084/m9.figshare.19070273.v2
title: The transition from invariant to action-dependent visual object representation in human dorsal pathway

description: Experimental stimuli. fMRI data. analysis results.
DOI: 10.14457/cu.the.2008.2139
title: ความต้องการล่ามในงานสาธารณสุขไทย : กรณีศึกษาโรงพยาบาลเอกชน 3 แห่งในเขตกรุงเทพมหานคร

description: สารนิพนธ์นี้มีจุดมุ่งหมายที่จะศึกษาถึงความต้องการล่าม ประเด็นปัญหาที่ล่ามประสบ ในขณะทำงานและการประเมินผลของล่ามในงานสาธารณสุขไทย โดยเลือกกรณีศึกษาใน โรงพยาบาลสามแห่ง อันได้แก่ โรงพยาบาลกรุงเทพ โรงพยาบาลพญาไท ๒ และโรงพยาบาลบำรุงราษฎร์ ผู้วิจัยได้ทำการสัมภาษณ์ผู้จ้างล่าม ๓ คนจากทั้ง ๓ โรงพยาบาลและสัมภาษณ์ล่าม ประจำในโรงพยาบาล ๘ คน จากทั้ง ๓ โรงพยาบาล ทั้งที่เป็นชาวไทยและชาวต่างประเทศ จากการศึกษาพบว่า ภาษาอารบิคเป็นภาษาที่มีความต้องการมากที่สุด ตามด้วย ภาษาญี่ปุ่น ภาษาอังกฤษ ภาษาจีนกลาง และภาษาพม่า ล่ามควรที่จะต้องมีความรู้พื้นฐานด้าน การรักษาพยาบาลบ้างเพื่อให้สะดวกต่อการทำงานทั้งของล่ามเองและของแพทย์ ปัญหาส่วน ใหญ่ที่ล่ามประสบคือ เรื่องของอารมณ์ที่ไม่คงที่ของผู้ป่วย ซึ่งล่ามจะต้องใจเย็นและอธิบายถึงสิ่งต่างๆให้แก่ผู้ป่วยและญาติได้เข้าใจ วัฒนธรรมก็เป็นอีกปัญหาหนึ่งที่ล่ามต้องระมัดระวังเพราะถือ เป็นเรื่องที่ละเอียดอ่อนมาก เช่น การพูดคุยกับเพศตรงข้ามในบางประเทศ หรือบางศาสนา ซึ่งล่ามจะต้องเรียนรู้และตามการพัฒนาของวัฒนธรรมให้ทันอยู่เสมอ ล่ามยังต้องคอยประเมินตนเองเพื่อพัฒนาการทำงานของตนเอง ทั้งในเรื่องของภาษาและเรื่องของการบริการผู้ป่วย
DOI: 10.6084/m9.figshare.19076852
title: NBPT保护剂（黑土）

description: black soil
DOI: 10.6084/m9.figshare.19076852.v2
title: NBPT保护剂（黑土）

description: black soil
DOI: 10.6084/m9.figshare.19076852.v1
title: NBPT保护剂（黑土）

description: black soil
DOI: 10.48370/ofd/llcrlr
title: Athelia decipiens (Hӧhn. Litsch.) J.Erikss., 3000

description: Fungarium Macromycetes
DOI: 10.48370/ofd/2v7ls8
title: Athelia decipiens (Hӧhn. Litsch.) J.Erikss., 3100

description: Fungarium Macromycetes
DOI: 10.15161/oar.it/74467
title: CovidStat project data

description: This record contains the daily updated data of the CovidStat project. CovidStat is a project carried out by the CovidStat Working Group at INFN, whose creation was promoted within the Italian National Institute of Nuclear Physics with the aim of making a statistical analysis of the data provided daily by the Civil Protection on the spread of the pandemic in Italy. CovidStat data can interactively be browsed at https://covid19.infn.it.
description: The software to process this Root TTree is in the related identifier. Be sure to use the right corresponding version, based on the data in which Root TTree was generated.
DOI: 10.5281/zenodo.5910288
title: Vascular access and clinical competency: Which elements matter? The development of three bottom-up and evidence-grounded self-assessment tools

description: Dataset from Rigo C, Grazioli M, Caravella G, Ursino F, Zerla P, Magon A, Dellafiore F, Caruso R. Vascular access and clinical competency: Which elements matter? The development of three bottom-up and evidence-grounded self-assessment tools. J Vasc Access. 2021 Jun 18:11297298211026447. doi: 10.1177/11297298211026447. Epub ahead of print. PMID: 34148385. Abstract <strong>Background: </strong>Assessing competency in the speciality of vascular access is still limited, and few valid and reliable tools are available. Therefore, this study aimed to develop and validate three different tools for assessing competency in managing the care of short peripheral cannulas (SPCs), midlines, peripherally inserted central catheters (PICCs), centrally inserted central catheters (CICCs), and arterial catheters (ACs) (tool one), placing SPCs (tool two), placing PICCs and midlines (tool three). <strong>Methods: </strong>A two-phase and multi-method design was adopted. Phase one was implemented to develop the initial pool of items for each tool, starting from a literature overview. Panel discussions were adopted for developing the items. In phase two, the developed items were tested for content and face validity, involving a panel of 10 experts. Once obtained adequate content validity, a cross-sectional data collection was implemented to enroll three samples of healthcare workers who had to assess their competency through the developed tools. Dimensionality was assessed by performing a principal component analysis (PCA) and assessing internal consistency (Cronbach's α). <strong>Results: </strong>Tool one had 26 items, and the dimensionality was given by placement, risk assessment, procedure conformity and traceability, and patient education to self-care. Tool two had 35 items; its principal components were: risk evaluation, identification, clinical assessment and orientation to self-care, placement, and procedure registration shaped the competency of placing SPCs. Tool three had 31 items; its principal components were: risk assessment, placement, conformity to standards and procedure traceability, education, and orientation to self-care were the essential elements for adequately placing midlines and PICCs. Cronbach's α values ranged between 0.806 and 0.959. <strong>Conclusions: </strong>The three developed tools reflected the core elements of competency in each application area, representing an initial framework that could be useful in future research and educational projects. Cross-national investigations are required to corroborate the described results.
DOI: 10.5281/zenodo.5910287
title: Vascular access and clinical competency: Which elements matter? The development of three bottom-up and evidence-grounded self-assessment tools

description: Dataset from Rigo C, Grazioli M, Caravella G, Ursino F, Zerla P, Magon A, Dellafiore F, Caruso R. Vascular access and clinical competency: Which elements matter? The development of three bottom-up and evidence-grounded self-assessment tools. J Vasc Access. 2021 Jun 18:11297298211026447. doi: 10.1177/11297298211026447. Epub ahead of print. PMID: 34148385. Abstract <strong>Background: </strong>Assessing competency in the speciality of vascular access is still limited, and few valid and reliable tools are available. Therefore, this study aimed to develop and validate three different tools for assessing competency in managing the care of short peripheral cannulas (SPCs), midlines, peripherally inserted central catheters (PICCs), centrally inserted central catheters (CICCs), and arterial catheters (ACs) (tool one), placing SPCs (tool two), placing PICCs and midlines (tool three). <strong>Methods: </strong>A two-phase and multi-method design was adopted. Phase one was implemented to develop the initial pool of items for each tool, starting from a literature overview. Panel discussions were adopted for developing the items. In phase two, the developed items were tested for content and face validity, involving a panel of 10 experts. Once obtained adequate content validity, a cross-sectional data collection was implemented to enroll three samples of healthcare workers who had to assess their competency through the developed tools. Dimensionality was assessed by performing a principal component analysis (PCA) and assessing internal consistency (Cronbach's α). <strong>Results: </strong>Tool one had 26 items, and the dimensionality was given by placement, risk assessment, procedure conformity and traceability, and patient education to self-care. Tool two had 35 items; its principal components were: risk evaluation, identification, clinical assessment and orientation to self-care, placement, and procedure registration shaped the competency of placing SPCs. Tool three had 31 items; its principal components were: risk assessment, placement, conformity to standards and procedure traceability, education, and orientation to self-care were the essential elements for adequately placing midlines and PICCs. Cronbach's α values ranged between 0.806 and 0.959. <strong>Conclusions: </strong>The three developed tools reflected the core elements of competency in each application area, representing an initial framework that could be useful in future research and educational projects. Cross-national investigations are required to corroborate the described results.
DOI: 10.5523/bris.3jrb4mejp9vfd2qb3s7dreymr1
title: IEA15MW_Bristol

description: This folder contains two YAML files corresponding to the two versions of the IEA15MW wind turbine, including updated blade models that are feasible and optimised.
DOI: 10.5281/zenodo.5910343
title: Uralic Typological database - UraTyp

description: Miina Norvik, Yingqi Jing, Michael Dunn, Robert Forkel, Terhi Honkola, Gerson Klumpp, Richard Kowalik, Helle Metslang, Karl Pajusalu, Minerva Piha, Eva Saar, Sirkka Saarinen and Outi Vesakoski (ms. 2021) Uralic typology in the light of new comprehensive data sets (submitted to Journal of Uralic Linguistics)The status of the manuscript will be updated here and at https://bedlan.net/.
DOI: 10.48370/ofd/hba39s
title: Peniophora incarnata (Pers.) P. Karst, 2045

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.19076927
title: Data of Potential of chemical stabilizers to prolong urease inhibition in the soil-plant system

description: 化学稳定剂在土壤-植物系统中延长脲酶抑制的潜力数据
DOI: 10.6084/m9.figshare.19076927.v1
title: Data of Potential of chemical stabilizers to prolong urease inhibition in the soil-plant system

description: 化学稳定剂在土壤-植物系统中延长脲酶抑制的潜力数据
DOI: 10.6084/m9.figshare.13235467
title: Human urine-based fertilizers: A review

description: Urine contains most of the nutrients excreted by humans. They are mainly released into the environment and contribute to the strong disruption of planetary biogeochemical cycles. These nutrients could be separated at source and used in agriculture. Once the urine is separated different treatments can be applied to stabilize nitrogen, reduce the volume, treat contaminants, or extract nutrients. These treatments and the resulting fertilizers have different characteristics and environmental impacts that must be assessed. We reviewed the characteristics of six treatments and the resulting fertilizers. The studied treatments were restricted to those that retain the most nutrients: storage, acidification, alkalinization, nitrification, and mixture with organic substrate. Phosphorus precipitation was also included, as it is one of the most developed treatments. Volume reduction posttreatments were also considered. We compared these treatments and the resulting fertilizers in terms of nutrient forms and concentrations, fertilizer efficiency, contaminant removal, energy, and chemical consumption. Although some parameters, such as fertilizer efficiency or pharmaceutical removal were in the same range, the nutrient concentrations and the energy and chemical consumption requested by fertilizer production varied widely. Holistic studies and pilot facilities implemented at a larger scale are needed in order to assess the whole value chain.
DOI: 10.6084/m9.figshare.13235467.v1
title: Human urine-based fertilizers: A review

description: Urine contains most of the nutrients excreted by humans. They are mainly released into the environment and contribute to the strong disruption of planetary biogeochemical cycles. These nutrients could be separated at source and used in agriculture. Once the urine is separated different treatments can be applied to stabilize nitrogen, reduce the volume, treat contaminants, or extract nutrients. These treatments and the resulting fertilizers have different characteristics and environmental impacts that must be assessed. We reviewed the characteristics of six treatments and the resulting fertilizers. The studied treatments were restricted to those that retain the most nutrients: storage, acidification, alkalinization, nitrification, and mixture with organic substrate. Phosphorus precipitation was also included, as it is one of the most developed treatments. Volume reduction posttreatments were also considered. We compared these treatments and the resulting fertilizers in terms of nutrient forms and concentrations, fertilizer efficiency, contaminant removal, energy, and chemical consumption. Although some parameters, such as fertilizer efficiency or pharmaceutical removal were in the same range, the nutrient concentrations and the energy and chemical consumption requested by fertilizer production varied widely. Holistic studies and pilot facilities implemented at a larger scale are needed in order to assess the whole value chain.
DOI: 10.6084/m9.figshare.18517874
title: Nontarget mass spectrometry and in silico molecular characterization of air pollution from the Indian subcontinent

description: <br>Supplementary Information, datasets, and source data (Figures 1-8) for the study<i> </i><b>Papazian <i>et al</i>., 2022</b><i>, Nontarget mass spectrometry and in silico molecular characterization of air pollution from the Indian subcontinent</i><i>,</i><i> </i>published in Communications Earth & Environment.<br>
DOI: 10.6084/m9.figshare.18517874.v1
title: Nontarget mass spectrometry and in silico molecular characterization of air pollution from the Indian subcontinent

description: <br>Supplementary Information, datasets, and source data (Figures 1-8) for the study<i> </i><b>Papazian <i>et al</i>., 2022</b><i>, Nontarget mass spectrometry and in silico molecular characterization of air pollution from the Indian subcontinent</i><i>,</i><i> </i>published in Communications Earth & Environment.<br>
DOI: 10.21227/ebqq-pf96
title: TIMIT

description: TIMIT dataset has 630 speakers containing 10 utterances for each speaker.
DOI: 10.6084/m9.figshare.19076921
title: Newspaper Columns.mx20

description: Corpus-assisted analysis of online newspaper columns<br>Rhetorical analysis of corpus Mixed-method apprach (Frequency and Chi-square analysis and qualitative analysis)
DOI: 10.48370/ofd/erxm2c
title: Peniophora incarnata (Pers.) P. Karst, 2212

description: Fungarium Makromycetes
DOI: 10.6084/m9.figshare.19076948
title: Supplementary Material for: Polymorphism in Thymidylate Synthase Gene Predicts Survival and Toxicity in North Indian Lung Cancer Patients Undergoing Platinum-Based Doublet Chemotherapy

description: Abstract Background: With an estimated 1.8 million deaths, lung cancer is one of the widely reported malignancies, with substantial morbidity and mortality rates. Thymidylate synthase (TS) is an important drug target for platinum-based doublet chemotherapy as it is the only de novo source of thymidylate production in the cell. TS polymorphisms in the 5'UTR of Thymidylate synthase enhancer region (TSER) 2R/3R and 3'- UTR 1494del6 are investigated in this study. Methods: A total of 700 lung cancer patients with platinum-based doublet chemotherapy were recruited in this study. TSER (2R/3R) and TS 1494del6 polymorphisms in North Indian lung cancer patients were examined, and statistical analysis was performed. Results: According to our findings, patients with the wild genotype (2R/2R) for the TSER polymorphism had a longer median survival time as compared to patients harboring the mutant type genotype (3R/3R) [MST=9.77 vs. 7.57 months; p=0.04]. On the contrary, patients with the mutant 14946del6 polymorphism (-6/-6) had a longer survival time than patients with the wild-type genotype (+6/+6) [MST=7.23 vs. 9 months]. Further, our findings elucidated that the patients with heterozygous genotype (2R3R) for TSER polymorphism had a 2.30-fold increased risk of developing leukopenia (AOR=2.30, 95% CI=0.96-5.52; p=0.05). A substantial risk of 5.14-fold constipation was found in heterozygous genotype (2R3R) when intermediate grade 2 toxicity was compared with low toxicity (grade 1) (p=0.007).An increased risk of nausea/vomiting was observed in patients with mutant genotype (-6/-6bp) for 1494 ins/del6 polymorphism compared to patients with wild-type genotype (+6/+6bp) (AOR= 2.77; 95%CI=1.10-6.96, p=0.03). Conclusion: According to our findings, TSER and the 1494del6 polymorphism may operate as a prognostic marker in lung cancer patients receiving platinum-based chemotherapy. Furthermore, TS polymorphisms may influence the onset of platinum-related toxicity, such as hematological and gastrointestinal toxicity. These findings might facilitate therapeutic decisions for individualized therapy in lung cancer patients. Keywords: Lung cancer, Thymidylate synthase, survival, platinum-based chemotherapy, polymorphism, toxicity
DOI: 10.5441/001/1.4h490c02/1
title: Partial migration in the Mediterranean storm petrel (BirdLife Malta)-light levels

description: Lago P, Austad M, Metzger B (2019) Partial migration in the Mediterranean storm petrel Hydrobates pelagicus melitensis. Marine Ornithology 47: 105–113.
description: Studying the migration routes and wintering areas of seabirds is crucial to understanding their ecology and to inform conservation efforts. Here we present results of a tracking study carried out on the little-known Mediterranean Storm Petrel Hydrobates pelagicus melitensis. During the 2016 breeding season, Global Location Sensor (GLS) tags were deployed on birds at the largest Mediterranean colony: the islet of Filfla in the Maltese Archipelago. The devices were retrieved the following season, revealing hitherto unknown movements and wintering areas of this species. Most individuals remained in the Mediterranean throughout the year, with birds shifting westwards or remaining in the central Mediterranean during winter. However, one bird left the Mediterranean through the Strait of Gibraltar and wintered in the North Atlantic. Our results from GLS tracking, which are supported by data from ringed and recovered birds, point toward a system of partial migration with high inter-individual variation. This highlights the importance of trans-boundary marine protection for the conservation of vulnerable seabirds.
DOI: 10.5441/001/1.4h490c02/2
title: Partial migration in the Mediterranean storm petrel (BirdLife Malta)-tracks

description: Lago P, Austad M, Metzger B (2019) Partial migration in the Mediterranean storm petrel Hydrobates pelagicus melitensis. Marine Ornithology 47: 105–113.
description: Studying the migration routes and wintering areas of seabirds is crucial to understanding their ecology and to inform conservation efforts. Here we present results of a tracking study carried out on the little-known Mediterranean Storm Petrel Hydrobates pelagicus melitensis. During the 2016 breeding season, Global Location Sensor (GLS) tags were deployed on birds at the largest Mediterranean colony: the islet of Filfla in the Maltese Archipelago. The devices were retrieved the following season, revealing hitherto unknown movements and wintering areas of this species. Most individuals remained in the Mediterranean throughout the year, with birds shifting westwards or remaining in the central Mediterranean during winter. However, one bird left the Mediterranean through the Strait of Gibraltar and wintered in the North Atlantic. Our results from GLS tracking, which are supported by data from ringed and recovered birds, point toward a system of partial migration with high inter-individual variation. This highlights the importance of trans-boundary marine protection for the conservation of vulnerable seabirds.
DOI: 10.48370/ofd/g2mpej
title: Peniophora incarnata (Pers.) P. Karst, 2346

description: Fungarium Makromycetes