cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/y2wm6yxrc3
title: Effects of the CYP3A inhibitors, voriconazole, itraconazole, and fluconazole on the pharmacokinetics of osimertinib in rats

description: Osimertinib, as third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment approved to treat advanced T790M mutation-positive tumors. Triazole antifungals are therapeutic drugs for patients with cancer to reduce the risk of opportunistic fungal infections. In this study, we investigated whether three triazole antifungals (voriconazole, itraconazole, and fluconazole) could affect the pharmacokinetics of osimertinib in rats. We reported that when co-administered with voriconazole and fluconazole, the Cmax of osimertinib increased by 58.04% and 53.45%, respectively; the AUC0–t of osimertinib increased by 62.56% and 100.98%, respectively. However, when co-administered with itraconazole, the Cmax and AUC0–t of osimertinib increased by 13.91% and 34.80%, respectively. Our results revealed that voriconazole and fluconazole could significantly influence the pharmacokinetic profiles of osimertinib in rats, whereas the strong inhibitor CYP3A itraconazole did not; co-administration of osimertinib and voriconazole or fluconazole is not recommended in ongoing clinical practice.
DOI: 10.17632/3zgzkddrjd
title: Supplementary data Ruiz-Monachesi&Martínez

description: Supplementary data from Ruiz-Monachesi&Martínez 
Table S1 shows lizards species studied and references from we obtain data of secretory glands and reproductive mode
Supplemetary S2 shows separate behavioural types analyses (Activity, Aggressiveness, Boldness, Exploration, Sociability)
DOI: 10.17632/4py4vmzx29
title: LDHU3_09.1190

description: Elongation factor-1 gamma (EF1G); Leishmania donovani (HU3 strain)
DOI: 10.17632/54kvbm29dc
title: Cvmb

description: Cvmb: a quantitative analysis software of pitch mesophase carbon microspheres based on OpenCV image processing technology
Double-click cvmb.exe after downloading to use it.
The software needs to be installed in an all-English directory, and requires that no special symbols be included in the name of the image entered.
If you encounter problems with the runtime, please run the develop version first.The develop version comes with a console to check for problems when the software is not running properly.
When encountering problems that cannot be solved, please contact the e-mail address：956963139@qq.com or wbq12334@gmail.com
DOI: 10.17632/cfwy3y76jb
title: Synthetic Parabolic Trajectories Dataset in Hexapod Robots

description: Parabolic trajectories constitute the primary motion of a robotic leg. Therefore, the data used to train models requires variations to the ideal (proposed) trajectories. Thus, it is essential to generate random sequences based on parabolic trajectories in each degree of freedom so that, collectively, they create a random three-dimensional step. The database comprises three classes of planar movements—two parabolic and one sigmoidal—representing one degree of freedom. Its structure consists of 200 timesteps, indicating the discretization of the continuous trajectory range into 1000 uniformly distributed trajectories across the three classes of movements in each degree of freedom.
DOI: 10.17632/h53bg5pvyx
title: A study of "Targeting anaplastic lymphoma kinase ameliorates glioblastoma by inducing autophagic cell death". Lili Feng et al.

description: This dataset was for "Targeting anaplastic lymphoma kinase ameliorates glioblastoma by inducing autophagic cell death".
DOI: 10.17632/jymtst88jm
title: The effect of Holder pasteurization on the lipid and metabolite composition of human milk

description: The data set includes MS and MSMS data collected from the analysis of 39 human milk (HM) samples using targeted dynamic iterated DDA of (pre)annotated metabolic features using a reference database (HMDB) and untargeted iterated DDA split into several m/z intervals. 15 HM samples (labelled as "LM") were raw milk samples from mothers of preterm infants and 12 HM samples (labelled as "LMD") were from the Human Milk Bank and were analyzed before ("Pre") and after ("Post") Holder pasteurization.
MS data sets: 2 blanks and a set of QCs (5 and 4 in ESI(+) and ESI(-), respectively) were injected at the beginning of the sequence for system conditioning and MS2 data acquisition. Then, the sample batch including 39 milk samples, 10 QCs (1 QC every 6 samples and 2 at the beginning and at the end of the samples) and 2 blanks (end of sample batch) were analyzed (B_Synergi_pos_and_neg*). In addition, after the sample batch, MS2 spectra were also acquired in consecutive QC replicates using untargeted iterated DDA in the [70-200], [200-300], [300-400], [400-500], [500-6000], [600-700], [700-800], [800-900], [900-1200] and [1200-1500] Da ranges (i-DDA). For the ESI(-), the acquisition in the m/z interval [1200-1500] failed and hence data was not available.
Peak table generation was carried out using XCMS software. The centWave method was used for peak detection with the following parameters: mass accuracy, 15 ppm; peak width, (5,20); snthresh, 6; prefilter, (3,100); noise, 0; minimum difference for overlapping peaks: 0.01 Da; intensity weighted m/z values of each feature were calculated using the wMean function; Peak limits used for integration: Mexican hat filtered data. RT correction was carried out using the “obiwarp” method. Peak grouping was carried out using the “density” method using mzwid = 0.015, bw = 5 and minFraction = 0.5. Missing data points were filled by reintegrating the raw data files in the regions of the missing peaks using the fillPeaks method. The CAMERA package was used for the identification of pseudospectra based on peak shape analysis, isotopic information and intensity correlation across samples. 
Raw MSMS data (.D) was converted into .ms2 and .mgf format using ProteoWizard. ms2 data was directly imported into MATLAB (Synergi_ms2_data_pos_and_neg data structures).

*Contains dataset objects and PLS-Toolbox (Eigenvector Research Inc.) for their inspection is required.
Funding Sources
This work was supported by the Instituto de Salud Carlos III, Spain [grant numbers CD19/00176  and CP16/00034 ]; the Ministry of Science and Innovation, Spain [grant number IJC2018-036209-I ], Generalitat Valenciana [project number GV/2021/186 ], and the European Union's Horizon 2020 Research and Innovation Programme through the Nutrishield project (https://nutrishield-project.eu/) [Grant Agreement No 818110 ].
DOI: 10.17632/mxv2c47j8t
title: R_Estágio

description: Relatório de estágio
DOI: 10.17632/ndvh4whc6n
title: LINF_260024500

description: TLC domain containing protein; Leishmania infantum (strain JPCM5)
DOI: 10.17632/xs8kjgc56d
title: Yangmuchuan

description: Four representative samples were collected from syntectonic leucogranitic dykes, in order to constrain the geochronological framework of Yangmuchuan gneiss dome. Zircon U-Pb isotopes were measured by LA-ICP-MS. In combination with previous research results, it also provides a reliable geochronological basis for the study of the orogenesis of the Jiao-Liao-Ji orogenic belt.
DOI: 10.17632/xvk3p67wjz
title: LINF_320023800

description: SMN
Leishmania infantum (strain JPCM5)
DOI: 10.17632/2s69d2gn7h
title: Mobile Mixed Reality for Critical Thinking in Healthcare Education

description: This dataset is linked to a submission to Elsevier titled: "Exploring mobile mixed reality for critical thinking in nursing and healthcare education: a systematic review".
Background: Mixed reality has increasingly been utilised in nursing and healthcare higher education as the ubiquity of mobile devices improves to access virtual environments (i.e., mobile mixed reality). However, the pedagogical consideration of how mobile mixed reality facilitates critical thinking skills is yet to be explored. 
Objective: This systematic review investigated the state of the art of how mobile mixed reality facilitates critical thinking skills in healthcare higher education. 
Methods: The review followed the PRISMA protocol and was registered prospectively with PROSPERO. A search in seven databases (MEDLINE, PsychINFO, AMED, ERIC, Scopus, Cochrane, and Web of Science) was conducted with 3488 titles and abstracts screened according to pre-determined inclusion and exclusion criteria, resulting in 12 included studies. The quality of included studies was evaluated using the Mixed Methods Assessment Tool (MMAT). 
Results: The breadth of healthcare disciplines was limited to dentistry, medicine, nursing, midwifery, and paramedicine who mainly utilised bespoke scenarios on head mounted displays. Most scenarios were emergency or critical response by nature, with limited time provided for pre-brief, debrief, or overall user time. Only two studies directly measured critical thinking, with others indirectly referring to development of ‘decision making’ by experience of diagnosis, interpretation, analysis, and evaluation of healthcare scenarios in a mixed reality environment. Affordances and design principles for future development of mobile mixed reality for critical thinking in nursing and healthcare higher education are identified. 
Conclusion: While some pedagogical affordances of mobile mixed reality can be identified in a narrow number of healthcare disciplines; there remains to be limited valid measure of critical thinking skills used to quantify effectiveness. Future studies would benefit to consider scenarios beyond emergency and critical responses, include longitudinal studies that reflect development of critical thinking over time, and exploration of co-designed scenarios with and by nursing and allied healthcare students. 
Registration: PROSPERO (ID: CRD42021286931).
DOI: 10.17632/324h8jhdm2
title: Microscale normal compression behaviors of clay aggregates: A coarse-grained molecular dynamics study

description: Supplementary data for "Microscale normal compression behaviors of clay aggregates: A coarse-grained molecular dynamics study".
DOI: 10.17632/dp43ny2xj5
title: Clam shrimp from the Lower Cretaceous Lishugou Formation in eastern Liaoning, northeastern China

description: Abundant clam shrimp were recovered from the Lower Cretaceous Lishugou Formation near Xiaowenzhigou village, northwestern Huanren Manchu Autonomous County, Benxi City, eastern Liaoning Province, which belong to a Yanjiestheria Fauna. In total twelve complete and fragemented specimens were documented in this dataset. A fossil locality map and columnar section have also been included in this dataset.
DOI: 10.17632/jwg3mpzpyy
title: Total magnetic intensity map of the Charity Shoal structure, northeastern Lake Ontario

description: Magnetic survey data over the Charity Shoal Structure in northern lake Ontario Canada. Data shows large anomaly over suspected impact structure. Grid provided is the grid used to create the models of Charity Shoal
DOI: 10.17632/mp2s5pd7dt
title: Microencapsulation preparation data

description: The microencapsulated inhibitors were experimentally prepared and the inhibition effect and inhibition mechanism of the inhibitors were investigated by temperature programmed experiments, thermogravimetric experiments, infrared spectroscopy experiments and quantum chemical simulations.Preparation and experimental data on microencapsulated inhibitors and other correlations.
DOI: 10.17632/ttjsh9prgp
title: LINF_050016900

description: protein of unknown function - conserved
Leishmania infantum (strain JPCM5)
DOI: 10.17632/5mnpzn87y5
title: LINF_160021000

description: protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/62c5n9fw6g
title: Molecular Dynamics Simulation of Graphene/n-Octadecane Composite Phase Change Material on Cu Nano-surface

description: In this work, Cu surface and amorphous n-octadecane composite system and Cu surface and graphene/n-octadecane composite system were constructed. By performing MD simulation, the microscopic behavior and interaction mechanism of alkane molecules in the system will be examined. The results may provide a microscopic mechanism explanation for the enhancement of thermal conductivity of CPCM by carbon nanomaterials and metal nanomaterials.
DOI: 10.17632/dz283xnfp3
title: AA Tofacitinib Supplementary Table 1

description: Alopecia areata recurrence patterns in children and young adults while on systemic tofacitinib therapy
DOI: 10.17632/r2w4kj32pv
title: Data for: Gender and Peer Effects on Performance in Social Networks

description: Our zip file contains the data set used in our paper and the codes Stata and R that we used to estimate the models from the data set.
DOI: 10.17632/tbdzbt3vrs
title: LDHU3_11.0370

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/v227dv69wx
title: LDHU3_17.0660

description: Protein of unknown function - conserved; Leishmania donovani (HU3 strain)
DOI: 10.17632/zyk5m599rw
title: LINF_250011100

description: protein of unknown function - conserved
Leishmania infantum (strain JPCM5)
DOI: 10.17632/3wmm84sfgb
title: LINF_310015700

description: Hypothetical protein - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/626pg2bnsy
title: Gopher Tortoise Social and Spatial Structure, Boyd Hill Nature Preserve

description: Social interaction and location data for gopher tortoises in the Boyd Hill Nature Preserve, located in Pinellas County, Florida, USA and the R code needed to perform spatial and social network analysis of the data.  The social interaction data was manually extracted from time-lapse videos taken by camera traps located at the entrance of tortoise burrows.  Location data was collected using radio telemetry.
DOI: 10.17632/7c3rr2pg9n
title: LINF_310021100

description: pentamidine resistance protein 1 | PRP1 | ABCC7
Leishmania infantum (strain JPCM5)
DOI: 10.17632/kz29z9n3jc
title: Bryson_MOLECULAR-CELL-D-22-00555_Figure_2C

description: A giant virus genome is densely packaged by stable nucleosomes within virions.
The two doublet histones of Marseillevirus are distantly related to the four eukaryotic core histones and wrap 121 basepairs of DNA to form remarkably similar nucleosomes. By permeabilizing Marseillevirus virions and performing genome-wide nuclease digestion, chemical cleavage and mass spectrometry assays, we find that the higher-order organization of Marseillevirus chromatin fundamentally differs from that of eukaryotes. Marseillevirus nucleosomes fully protect DNA within virions as closely abutted 121-bp DNA wrapped cores without linker DNA or phasing along genes. Likewise, we observed that nucleosomes reconstituted onto multi-copy tandem repeats of a nucleosome positioning sequence are tightly packed. Dense promiscuous packing of fully wrapped nucleosomes rather than “beads-on-a-string” with genic punctuation represents a new mode of DNA packaging by histones. We suggest that doublet histones have evolved for viral genome protection and may resemble an early stage of histone differentiation leading to the eukaryotic octameric nucleosome.
Variant assembly analyses of viral chromatin. Tapestation gel profiles of nucleosome assembly reactions containing Hz-He andHδ-Hγ tetramers and a 3-copy Widom 601 array with 40-bp linkers at histone:DNA ratios in lanes labeled: 0.25, 0.5, 1, 1.5, 2 and 2.5 after 5 min MNase treatment and DNA purification. Hz-He,Hδ-Hγ  and Xenopus laevis (X.l.) assemblies are shown as controls.
DOI: 10.17632/vpf2n8c7ty
title: THE SOCIAL AND POLITICAL STATUS OF ENGLISH IN PAKISTAN

description: The research explores English's social and political status in Pakistan and discusses English's role in the political and social class of Pakistani Society. English is being used in Pakistan as a golden key for highly paid jobs. This paper explores the influence of English on native languages. English is the official and second language of Pakistan, but Pakistan's ordinary peoples can rarely understand and speak. Thirty-four participants included university students, teachers, lecturers, doctors, and businessmen from the public and private sectors were chosen as a research sample. Data was collected through questionnaire constructs on Google form. Data analysis with the help of state formulas himself. Results show that English is affecting over Urdu and native languages. Results show the social and political status of English in Pakistan. This research recommended that educators and policymakers make English language teaching policies balanced in first and second languages.
DOI: 10.17632/w6fvw68gpx
title: Generic reporting form disinsection

description: Example of data recording form and calculations for draft revised guidelines
DOI: 10.17632/z3wwjmzrzd
title: LINF_120007900

description: ornithine decarboxylase (ODC); Leishmania infantum
DOI: 10.17632/zj9bg6ktjb
title: LDHU3_08.0170

description: hypothetical protein - conserved
Leishmania donovani (HU3 strain)
DOI: 10.17632/8t2vcgsjvw
title: Financial Toxicity in Northwest Syria

description: Supplementary documents, including ethical approval, questionnaires, anonymized row data, data analysis documents, and consent form
DOI: 10.17632/bk9s769t3t
title: Agent-based models predict emergent behavior of heterogeneous cell populations in dynamic microenvironments: POPULATION HETEROGENEITY (1/5)

description: Data and results for `POPULATION HETEROGENEITY` simulations. Simulations of all possible combinations of four populations (X, A, B, C) under colony and tissue context with different levels of parameter heterogeneity (0, 0.1, 0.2, 0.3, 0.4, and 0.5). For tissue context, the healthy cell populations also varies parameter heterogeneity independent of the cancerous cell populations. Each condition is run for 15 days (21600 ticks) with 20 replicates (random seeds 0 - 19). Cells are introduced to the center of the constant source environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The data.param folder contains .tar.xz compressed replicate sets for .PARAM output. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[populations]_[population heterogeneity]_[background heterogeneity] - [context] - C = colony context, cancerous cell populations only - CH = tissue context, cancerous cell populations and healthy cells - [populations] - X = cancerous cell population with basal parameters - A = cancerous cell population with max_height x 1.5 - B = cancerous cell population with meta_pref x 1.5 - C = cancerous cell population with migra_threshold x 0.5 - [population heterogeneity] - ## = heterogeneity value for cancerous cell populations (##/10) - [background heterogeneity] - ## = heterogeneity value for healthy cell population (##/10) Additional data and results for this simulation set available at: - doi: 10.17632/mjpcm5my8z - doi: 10.17632/hskf9mxbpw - doi: 10.17632/ynzsfdswjz - doi: 10.17632/p46dwfyvzg
DOI: 10.17632/dy8kpzwb65
title: LINF_350010800

description: protein of unknown function - conserved
Leishmania infantum (strain JPCM5)
DOI: 10.17632/f5wcpk3k86
title: Historical ferrous slag induces modern environmental problems in the Moravian Karst (Czech Republic)

description: Ferrous slag produced by a historic smelter is washed from the heap and transported by a creek through the cave system. There is concern that the slag fills cave spaces, abrades cave walls / calcite speleothems, and contaminates the aquatic environment with heavy metals and other toxic components. The study objectives were to better characterize the slag in its deposition site, map its transport through the cave system, characterize the effect of slag transport, and to judge the risks to both cave and aqueous environments. The study was based on methods of chemical and phase analysis supported laboratory experiments and geochemical modeling. The slag in the heap was dominated by amorphous glass phase (66 to 99 wt%) with mean composition of 49.8±2.8 wt% SiO2, 29.9±1.6 wt% CaO, 13.4±1.2 wt% Al2O3., 2.7±0.3 wt% K2O and 1.2±0.1 wt% MgO. Minerals such as melilite, plagioclase, anorthite, and wollastonite / pseudowollastonite with smaller amounts of quartz, cristobalite, and calcite were detected. Slag trace elements formally enrich the cave environment with Se, As, W, Y, U, Be, Cs, Sc, Cd, Hf, Ba, Th, Cr, Zr, Zn, and V. However, only Zr, V, Co, and As exceed specified limits for soils (US EPA and EU limits). The life of a 1 mm3 volume of slag was estimated to be 27,000 years. The mean residence time of the slag in the cave defined by the flood frequency was 47 years. The main conclusion was that the extent of slag weathering is small and that the slag does not contaminate the cave aqueous environment under given conditions. However, the slag enriched in U / Th can increase radon production as a result of alpha decay. The slag has an abrasive effect on surrounding rocks and disintegrated slag can contaminate calcite speleothems.
DOI: 10.17632/h9fybyjzfm
title: Coding agenda

description: Coding agenda for MeLA data
DOI: 10.17632/kx3n64gdbh
title: Data set-Risk and Main Contributing Factors for Constipation in Patients with Gastrointestinal Cancer: A Multicenter Cross-Sectional Study in China

description: SPSS dataset for paper named "Risk and Main Contributing Factors for Constipation in Patients with Gastrointestinal Cancer: A Multicenter Cross-Sectional Study in China"
DOI: 10.17632/27xfxhw5x4
title: LINF_340011700

description: enoyl-[acyl-carrier-protein] reductase
Leishmania infantum (strain JPCM5)
DOI: 10.17632/7pdfy5y67d
title: Supplementary file table S4_DUPISWITCH

description: Supplementary file table S4_DUPISWITCH
DOI: 10.17632/944sscwnfs
title: Cutaneous squamous cell carcinoma as a late and underrecognized manifestation of Incontinentia Pigmenti: a systematic review

description: Supplemental material.
DOI: 10.17632/pxhny3yjd9
title: February 2023 Tweets containing Atiku Abubakar

description: This dataset contains all the tweets posted between February 1st and 24th 2023 where Atiku Abubakar was mentioned.
DOI: 10.17632/sp36ghdx9k
title: Winter wheat FHB 2017-2019

description: Data on resistance of winter wheat breeding lines to FHB and toxin accumulation from three experimental years 2017 - 2019 and two loacations (Poznań, Radzików).
DOI: 10.17632/z5g82bjm95
title: Data for: Woody plant functional traits and phylogenetic signals correlate with urbanization in remnant forest patches

description: This data set contains all data used for analyzing woody plant functional traits and phylogenetic signals correlate with urbanization in remnant forest patches. It has three parts: (1) Accession number that the study includes data from NCBI; (2) Phylogenetic tree files and (3) Functional trait data of recorded plants.
DOI: 10.17632/grwf69pf3c
title: LINF_180008800

description: Hypothetical protein - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.17632/n6w2b6j2vg
title: Code for next generation sequencing data analysis of the Gene Expression Omnibus dataset GSE210779

description: This only contains the original code used to analyze the NGS data for the dataset. The associated manuscript will be published in Cell Reports.
DOI: 10.17632/tc6kssp9df
title: LINF_350032600

description: acyl-CoA dehydrogenase
Leishmania infantum (strain JPCM5)
DOI: 10.17632/tms6xgwbbx
title: A 5-year retrospective cohort study of basal cell carcinomas on the head and neck: anatomic location as a predictor of subclinical tumor extension

description: Supplementary Table 1, Supplementary Figures 1 - 5,
DOI: 10.17632/vfcg8ph44d
title: A learnable dynamic evolutionary optimization algorithm

description: Explanation for data folder: 
1. The Input folder contains the different coagulation bath environments in the ten test cases.
2. The Output folder contains performance data for each algorithm.
DOI: 10.17632/xbx7ckff96
title: LINF_350055600

description: mitogen-activated protein kinase | MPK13
Leishmania infantum (strain JPCM5)