cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12951466.v1
title: Fig. S3. muscleNS3 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.25592/dgs.corpus-1.0-type-31097
title: ABSCHNITT2C^ (MEINE DGS – annotiert. Öffentliches Korpus der Deutschen Gebärdensprache, 1. Release)
title: SEGMENT2C^ (MY DGS – annotated. Public Corpus of German Sign Language, 1st release)

description: Ein Type aus der Annotation von MEINEDGS mit allen seinen Tokens aus MEINEDGS: The Public DGS Corpus consists of more than 50 hours of video data from the DGS-Korpus project made available together with annotations for research purposes. In this project, data were collected all across Germany in the timeframe 2010-2012. The public corpus shows 330 informants in 4 different age groups (from 18 years on) from 13 different regions. All parts are conversations between two informants in German Sign Language (DGS). The majority of transcripts included cover discussions and reports on Deaf life and personal experiences, although there are examples of other tasks such as story retellings as well.<br>Transcripts are made available in iLex and ELAN format as well as in SRT subtitles format that can be imported in MaxQDA and other analysis tools, together with the mp4 video files in 360p50. Diese DOI identifiziert die Version 1.0 des Datensatzes.
description: A type from the annotation of MYDGS including all its tokens in MYDGS: Das Öffentliche DGS-Korpus besteht aus mehr als 50 Stunden Video aus dem Projekt DGS-Korpus, die zusammen mit Annotationen für Forschungszwecke zur Verfügung gestellt werden. Die Datenerhebung im Projekt fand im Zeitraum 2010-2012 in ganz Deutschland statt. Das öffentliche Korpus besteht aus Gesprächen jeweils zweier Informantinnen oder Informanten in Deutscher Gebärdensprache. Das Korpus umfasst 330 Informantinnen und Informanten in vier verschiedenen Altersgruppen (ab 18 Jahren) aus 13 verschiedenen Regionen. Der Schwerpunkt der Sammlung liegt auf Transkripten von Diskussionen und Berichten über das Leben Gehörloser sowie persönliche Erfahrungen, sie enthält aber auch Beispiele anderer Erhebungsformate wie Nacherzählungen.<br>Transkripte werden im iLex- und ELAN-Format sowie als SRT-Untertiteldateien (zum Import etwa in MaxQDA) zur Verfügung gestellt. Die zugehörigen MP4-Videodaten sind durchgängig im Format 360p50. This DOI identifies the version 1.0 of the dataset.
DOI: 10.6084/m9.figshare.12951463
title: Fig. S6. muscleNS6 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951466
title: Fig. S3. muscleNS3 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951460.v1
title: Table S3 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Clustering of all HLA-I and HLA-II epitopes
DOI: 10.6084/m9.figshare.12951469
title: Table S1 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: SARS-CoV2 Epitopes in common with previously studied SARS-CoV epitopes
DOI: 10.6084/m9.figshare.12951472
title: Fig. S4. muscleEnvelope from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951469.v1
title: Table S1 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: SARS-CoV2 Epitopes in common with previously studied SARS-CoV epitopes
DOI: 10.6084/m9.figshare.12951475.v1
title: Table S5 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Dataset of all HLA-I binding epitopes generated from NetCTLpan algorithm
DOI: 10.6084/m9.figshare.12951472.v1
title: Fig. S4. muscleEnvelope from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951481.v1
title: Fig. S2. muscleSpike from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951463.v1
title: Fig. S6. muscleNS6 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951478.v1
title: Fig. S8. muscleORF8 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951475
title: Table S5 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Dataset of all HLA-I binding epitopes generated from NetCTLpan algorithm
DOI: 10.6084/m9.figshare.12951478
title: Fig. S8. muscleORF8 from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.6084/m9.figshare.12951484.v1
title: Fig. S7. muscleORF7a from Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2

description: Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact <i>via</i> symptomatic and asymptomatic transmission. Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. Hence, work on developing a potential multi-subunit vaccine is the need of the hour. In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins as there is as yet, no clear information on the immunogenicity of these proteins. Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. Moreover, several useful insights were gleaned during these analyses. One of the most important insights is that all of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins, stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. These epitopes, after due validation <i>in vitro</i>, may thus need to be presented to the human body in that form of multi-subunit epitope-based vaccine that avoids such immunopathologies.
DOI: 10.25592/dgs.corpus-1.0-type-31120
title: FÄRBEN1^ (MEINE DGS – annotiert. Öffentliches Korpus der Deutschen Gebärdensprache, 1. Release)
title: TO-DYE1^ (MY DGS – annotated. Public Corpus of German Sign Language, 1st release)

description: Ein Type aus der Annotation von MEINEDGS mit allen seinen Tokens aus MEINEDGS: The Public DGS Corpus consists of more than 50 hours of video data from the DGS-Korpus project made available together with annotations for research purposes. In this project, data were collected all across Germany in the timeframe 2010-2012. The public corpus shows 330 informants in 4 different age groups (from 18 years on) from 13 different regions. All parts are conversations between two informants in German Sign Language (DGS). The majority of transcripts included cover discussions and reports on Deaf life and personal experiences, although there are examples of other tasks such as story retellings as well.<br>Transcripts are made available in iLex and ELAN format as well as in SRT subtitles format that can be imported in MaxQDA and other analysis tools, together with the mp4 video files in 360p50. Diese DOI identifiziert die Version 1.0 des Datensatzes.
description: A type from the annotation of MYDGS including all its tokens in MYDGS: Das Öffentliche DGS-Korpus besteht aus mehr als 50 Stunden Video aus dem Projekt DGS-Korpus, die zusammen mit Annotationen für Forschungszwecke zur Verfügung gestellt werden. Die Datenerhebung im Projekt fand im Zeitraum 2010-2012 in ganz Deutschland statt. Das öffentliche Korpus besteht aus Gesprächen jeweils zweier Informantinnen oder Informanten in Deutscher Gebärdensprache. Das Korpus umfasst 330 Informantinnen und Informanten in vier verschiedenen Altersgruppen (ab 18 Jahren) aus 13 verschiedenen Regionen. Der Schwerpunkt der Sammlung liegt auf Transkripten von Diskussionen und Berichten über das Leben Gehörloser sowie persönliche Erfahrungen, sie enthält aber auch Beispiele anderer Erhebungsformate wie Nacherzählungen.<br>Transkripte werden im iLex- und ELAN-Format sowie als SRT-Untertiteldateien (zum Import etwa in MaxQDA) zur Verfügung gestellt. Die zugehörigen MP4-Videodaten sind durchgängig im Format 360p50. This DOI identifies the version 1.0 of the dataset.