cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4750666.v1
title: Supplementary Material for: Expression Pattern of Smad4/GATA3 as a Predictor of Survival in Invasive Ductal Carcinoma of the Breast

description: <i>Background:</i> Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. <i>Methods:</i> The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. <i>Results:</i> Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. <i>Conclusion:</i> Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer.
DOI: 10.6084/m9.figshare.5127043.v1
title: Supplementary Material for: Use of Transarterial Chemoembolization (TACE) and Sorafenib in Patients with Unresectable Hepatocellular Carcinoma: US Regional Analysis of the GIDEON Registry

description: <b><i>Background: </i></b>Global Investigation of Therapeutic Decisions in Hepatocellular Carcinoma and of Treatment with Sorafenib (GIDEON) is a worldwide, prospective, non-interventional study to evaluate the safety of sorafenib in a variety of patient subsets. <b><i>Methods: </i></b>Eligible patients had unresectable hepatocellular carcinoma for whom the decision had been made to treat with sorafenib. Treatment strategies were instituted at the physician's discretion. Patient and disease characteristics, treatment practices, incidences of adverse events (AEs), and overall survival were collected. <b><i>Results: </i></b>In the United States, 563 patients were evaluable for safety. Subgroup analysis was performed for patients who underwent transarterial chemoembolization (TACE) prior to the initiation of sorafenib (group A, n=158), after the initiation of sorafenib only (group B, n=29), both (group C, n=38), or did not undergo TACE (n=318). Patient demographics were similar across the groups. In group A, 29% had Child-Pugh score B or C at diagnosis, and 19% had Barcelona Clinic Liver Cancer tumor stage C or D. In group B, 48% had Child-Pugh score B or C at study entry, and 31% had BCLC stage C or D. The majority of patients in all groups initially received full-dose sorafenib. Incidences of grade ≥3 drug-related AEs were 30%, 17%, and 16% in groups A, B, and C, respectively, and 22% in patients who did not undergo TACE. No new safety signals emerged. <b><i>Conclusions: </i></b>The results from GIDEON reaffirm that sorafenib can be safely used in the context of TACE.
DOI: 10.6084/m9.figshare.c.3937714_d4.v1
title: Additional file 13: of Genome analysis of the foxtail millet pathogen Sclerospora graminicola reveals the complex effector repertoire of graminicolous downy mildews

description: Jacalin-like domain protein genes predicted in genome of Sclerospora graminicola and their expression levels during infection. (XLSX 49 kb)
DOI: 10.60893/figshare.jap.25196738.v1
title: Supplement Number 1

description: Supplementary Information
for
Observation of Novel In-Gap States on Alkali Metal Dosed Ti2O3 film
DOI: 10.17632/dv4m9bbn9y
title: Central Spitsbergen Snow Avalanche Activity 2016-2020

description: These data include all individual snow avalanches and the associated daily avalanche activity index for all avalanches observed in Nordenskiöld Land on Spitsbergen, Svalbard, uploaded to the regObs database, and analyzed as a portion of a study investigating the synoptic controls on avalanche activity in this location (reference forthcoming). Data in this dataset were originally obtained from the regObs.no database (www.regobs.no). RegObs is the Norwegian Water Resources and Energy Directorate's system for acquiring, storing, and visualizing natural hazards observations in Norway. The data in this dataset were retrieved from regObs using methods contained in the now-deprecated Github repository at https://github.com/ragnarekker/varsomdata, and then manually checked and processed as described in the referenced publication. This dataset was developed and analyzed in a research paper examining the role of synoptic-scale atmospheric circulation patterns in the Nordenskiöld Land region of central Spitsbergen, the largest island in the Svalbard archipelago (reference forthcoming). This work found synoptic conditions leading to increased precipitation, stronger winds, and increased air temperatures were associated with more observed avalanche activity. The dataset includes avalanches observed during the winter months (December-May) from 1 December 2016 to 31 May 2020. Data are organized in two files. The first, "individual_avalanches.csv") includes the 632 individual avalanches identified in the regObs observations. Data from each avalanche identified is contained in a separate record (632 records). The second, "Daily_activity.csv", includes the daily avalanche activity considered in aggregate for all 729 winter days analyzed in this work. Each winter day is represented by a record (729 records). In addition, the “Daily_activity.csv” file contains the data related to the synoptic type derived from the Niedźwiedź Classification. This is a well-established subjective classification of atmospheric circulation types in the Svalbard region. The full description of the classification provided by Tadeusz Niedźwiedź from University of Silesia in Katowice (Poland) is found in: Niedźwiedź, T.: The atmospheric circulation, in: Climate and Climate Change at Hornsund, Svalbard, edited by: Marsz, A. A., and Styszyńska, A., Gdynia Maritime Univsersity, Gdynia, Poland, 57-74, 2013. These data are a unique dataset included in the analyses of the following publication: Hancock, H., Hendrikx, J., Eckerstorfer, M., and Wickström, S.: Synoptic control on snow avalanche activity in central Spitsbergen, The Cryosphere Discuss., 2021, 1-35, doi:10.5194/tc-2021-48, 2021.
DOI: 10.6084/m9.figshare.28284776.v1
title: Base de datos-Nursing students' attitudes towards climate change and sustainability: Across-sectional multisite study

description: Education is a social tipping intervention necessary for stabilising the earth's climate by 2050.Integrating sustainable healthcare into healthcare professionals' curricula is key to raising awareness.Objectives: This study aimed to: i) investigate nursing students' attitudes towards and awareness of climate changeand sustainability issues and their inclusion in nurse education, ii) explore differences across a range of countries,and iii) compare attitudes in 2019 with those of a similar sample in 2014.Design: A cross-sectional multicentre study. Data were collected through the Sustainability Attitudes in NursingSurvey (SANS_2) questionnaire.Settings: Seven different universities and schools of nursing in five countries (UK, Spain, Germany, Sweden, andAustralia).Participants: A convenience sample of first-year undergraduate nursing students.Methods: The SANS_2 questionnaire was self-administered by nursing students at the seven participating universitiesat the start of their undergraduate degree, between September 2019 and February 2020.Results: Participants from all seven universities (N = 846) consistently showed awareness and held positive attitudestowards the inclusion of climate change and sustainability issues in the nursing curriculum (M = 5.472;SD: 1.05; min-max 1–6). The highest-scored items were the relevance of climate change and sustainability to nursing. Esslingen-Tübingen students scored the highest in the ‘inclusion of climate change and sustainability in thenursing curricula’. Students at all universities applied the principles of sustainability to a significant extent athome. Nursing students' attitudes towards climate change and sustainability showed significantly higher valuesin 2019 (Universities of Plymouth, Brighton, Esslingen-Tübingen, Jaen, Murcia, Dalarna, and Queensland) thanin 2014 (universities of Plymouth, Jaen, Esslingen, and Switzerland).Conclusions: Nursing students have increasingly positive attitudes towards the inclusion of sustainability andclimate change in their nursing curriculum. They also recognise the importance of education regarding sustainabilityand the impact of climate change on health, supporting formal preparation for environmental literacy.It is time to act on this positive trend in nursing students' attitudes by integrating these competencies into nursingcurricula.
DOI: 10.6084/m9.figshare.28355237.v1
title: Freedom of information Decision for Psilocybin and MDMA Special Access-B Approvals in Australia from 2018 to 2022

description: This document is the <b>official notice of decision</b> from the <b>Therapeutic Goods Administration (TGA), Australian Government Department of Health and Aged Care</b>, regarding <b>Freedom of Information (FOI) request 4104</b>. The FOI request provides <b>historical regulatory data</b> on all <b>Special Access Scheme-B (SAS-B) applications</b> for <b>Psilocybin and MDMA</b> submitted between <b>January 1, 2018, and November 21, 2022</b>.The document details:The <b>number of applications lodged</b> under SAS-B for psilocybin and MDMA.The <b>outcomes of these applications</b>, including approvals, rejections, and pending cases.The <b>regulatory context</b> in which these applications were assessed.This FOI release is a <b>significant regulatory record</b>, offering <b>transparency into the TGA’s decision-making process</b> for psychedelic substances before their rescheduling in <b>July 2023</b>. It serves as a <b>key administrative law document</b> in understanding the evolution of psychedelic access in Australia and was one of the <b>main legal bases cited in the rescheduling process.</b>This dataset is a valuable resource for <b>researchers, policymakers, and legal professionals</b> examining the development of psychedelic medicine regulation in Australia.
DOI: 10.6084/m9.figshare.28355384.v1
title: General.Data. Proyect Glycerol.csv

description: <b>Objective</b>Endurance athletes face significant water loss during exercise, which can impact performance and increase the risk of dehydration. Glycerol hyperhydration has been explored as a strategy to improve hydration status before competition, especially when hydration opportunities are limited. The aim of this study was to evaluate the effects of glycerol hyperhydration on running economy (RE) in trained runners.<br><b>Methods</b>A clinical trial was conducted with 30 runners (15 men, 15 women) across three sessions. The first session involved determining VO<sub>2peak</sub> and setting running speeds for sessions 2 and 3. In the second session, participants performed a running test in a euhydrated state under fluid restriction, and in the third session, they received glycerol supplementation (22 ml/kg sports drink + 1.2 g/kg glycerol). Variables such as caloric cost unit (CCU), oxygen cost unit (OCU), heart rate (HR), body temperature (BT), and rating of perceived exertion (RPE) were assessed. Effect size computed as standardized mean differences (Cohen’s d).<br><b>Results</b>Glycerol supplementation significantly improved running economy, reducing CCU (<i>p</i> = 0.025, <i>d</i> = 0.43), OCU (<i>p</i> = 0.011, <i>r</i> = 0.46), HR (<i>p</i> = 0.029, <i>d</i> = 0.42), and RPE (<i>p</i> = 0.003, <i>d</i> = 0.60). Additionally, although BT slightly decreased (<i>p</i> = 0.053, <i>d</i> = 0.37), it did not reach statistical significance, suggesting a trend toward lower body temperature, potentially reflecting enhanced thermoregulation.<b>Conclusions</b>These findings suggest that glycerol supplementation improves the metabolic variables associated with running economy, such as the CCU and OCU, as well as cardiovascular responses and the RPE in trained runners.<br>
DOI: 10.6084/m9.figshare.28850783.v1
title: Skin metabolomics (100 Subjects - elbow crease)

description: Skin metabolomics (selected amino acid) measure at elbow crease among 100 individuals.
DOI: 10.17632/3h873vkhzy
title: Field survey data on the effectiveness of agrometeorological services for smallholder farmers in Niger

description: The dataset contains the answers of smallholder farmers to a semi-structured field survey and the 2020 yield plot measurements conducted in 8 municipalities of the Dosso and Tillabéri   regions in Niger. It is a systematic sampling of about 320 questionnaires and 192 yield plot samples equally distributed in eight municipalities of intervention. The dataset contains several pieces of information about the uptake and the impacts of a tailored climate service (CS) produced by the National Meteorological Service (NMS) and disseminated through a network that involves Ministry of Agriculture extension services at the municipal level developed in the context of the AdaptatioN Au changement Climatique, prévention des catastrophes et Développement agrIcole pour la sécurité Alimentaire du Niger (ANADIA) Project. The material gathered by the survey gives a picture of the preferences of local farmers in the broadcasting of climate services information and their consequent strategical and tactical decisions in farm practices. Moreover, the survey investigates the preferences regarding the information that farmers would like to receive during the cropping season. Furthermore, the measurement of yield and its relation to the farmers’ access to climate information and participation in training initiatives gives an indication of the impact of the CS on agricultural production in these regions.
The dataset could benefit further studies and investigations about CSs for smallholder farmers in semi-arid regions.

This article is a co-submission of the article: “Effectiveness of agrometeorological services for smallholder farmers: the case study in the regions of Dosso and Tillabéri in Niger” submitted to the journal Climate Services. https://doi.org/10.1016/j.cliser.2023.100360
DOI: 10.17632/d4c94r9254
title: fwXmachina example: Missing transverse energy regression

description: Dataset used in the MET estimation problem of https://arxiv.org/abs/2207.05602. Different algorithms were used to calculate missing transverse energy of QCD multijet background, VBF Higgs decaying to invisible particles, and ttbar. For each event, all the MET estimates and rho energy density values are reported here. Details of the algorithms and the variable descriptions can be found in our paper.
DOI: 10.17632/dn95n2drbx
title: Data for: Source Apportionment of Water-Soluble Brown Carbon in Aerosols over the Northern South China Sea: Influence from Land Outflow, SOA Formation and Marine Emission

description: ds01: the Concentrations of WSOC and Optical Parameters; ds02: Input Data of Positive Matrix Factorization (PMF) Model; ds03: Outputs of PMF; ds04: Multiple Linear Regression Analysis Data; ds05: Input Data of Potential Source Contribution Function (PSCF) Model.
DOI: 10.6084/m9.figshare.21314835.v1
title: Optimal_Tilt_USA_Alhamer_Grigsby_Mulford.xlsx

description: This dataset describes the optimal PV tilt angle for every county in the United States of America. The full description of this data is available in the open access literature. <br> Alhamer, E.; Grigsby, A.; Mulford, R. The Influence of <br> Seasonal Cloud Cover, Ambient Temperature and Seasonal Variations in Daylight Hours on the <br> Optimal PV Panel Tilt Angle in the United States. <em>Energies </em><strong>2022</strong>, <em>15</em>
DOI: 10.6084/m9.figshare.5432152.v1
title: VHFPT 2.0.zip

description: images to run the study in your own software, as well as livecode app
DOI: 10.6084/m9.figshare.7660268.v1
title: Supplementary Material for: End-Stage Kidney Diseases in Immigrant Groups: A Nationwide Cohort Study in Sweden

description: <b><i>Background:</i></b> Our aim was to study the association between the country of birth and incident end-stage kidney disease (ESKD) in several immigrant groups in Sweden, using individuals born in Sweden or with Swedish-born parents as referents. <b><i>Methods:</i></b> A cohort study of first- and second-generation immigrants residing in Sweden between January 1, 1998 and December 31, 2012 was performed. Outcomes were defined as having at least one registered diagnosis of ESKD in the National Patient Register. The incidence of ESKD in different immigrant groups was used in the Cox regression models to estimate hazard ratios (HRs) and 95% CIs. All models were stratified by sex and adjusted for age, geographical residence, educational level, marital status, and neighbourhood socioeconomic status. <b><i>Results:</i></b> Compared to their referents, higher incidence rates and HRs of ESKD (HR; 95% CI) were observed in general among foreign-born men (1.10; 1.04–1.16) and women (1.12; 1.04–1.21) but not among second-generation immigrants (persons born in Sweden with foreign-born parents). A particularly high ­incidence was noted among men and women from ­East-European countries, as well as from non-European regions. A lower incidence of ESKD was noted among men from Finland. <b><i>Conclusions:</i></b> We observed substantial differences in incidence of ESKD between immigrant groups and the Swedish-born population, which may be clinically relevant when monitoring preventive measures in patient subgroups with a higher risk of deteriorating kidney disease, and suggest higher attention to hypertension and diabetes control in immigrants. Mechanisms attributable to the migration process or ethnic differences may lead to an increased risk of ESKD.
DOI: 10.6084/m9.figshare.8095166.v1
title: Supplementary Material for: Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology

description: <b><i>Background:</i></b> Few data are available on associations of antiphospholipid (aPL) antibodies with cognitive and motor decline in aging, and cerebrovascular disease on in vivo neuroimaging and postmortem neuropathology. <b><i>Methods:</i></b> This longitudinal, clinical-pathologic study (aPL antibodies, brain infarcts, and cognitive and motor decline in aging), was derived from 2 ongoing community-based cohort studies. A panel of 3 aPL antibodies was assayed in serum from 956 older individuals (mean age = 81.1 years; 72% women). Serum was also tested in a subset for markers of inflammation (C-reactive protein [CRP]) and blood-brain barrier breakdown (matrix metalloproteinases, MMPs). Annual clinical evaluations documented cognitive (17 neuropsychological tests) and motor function including parkinsonism. Cerebrovascular disease data were derived from in vivo neuroimaging and postmortem neuropathologic evaluations (699 individuals). We examined associations of aPL with cognitive and motor decline, other serum markers, neuroimaging, and neuropathology. <b><i>Results:</i></b> Of 956 individuals, 197 (20.6%) had aPL positivity, defined as positivity on any of the assays, at the time of first measurement. During a mean follow-up of 6.6 years (SD 4), overall aPL positivity was not associated with change in global cognition (estimate = –0.005, SE 0.011; <i>p</i> = 0.622) or parkinsonian signs (estimate = –0.003, SE 0.017; <i>p</i> = 0.860). aPL were not associated with serum CRP or MMPs (both <i>p</i> &gt; 0.268). aPL were not associated with in vivo brain magnetic resonance imaging white matter hyperintensities or infarcts (both <i>p</i> &gt; 0.376). Among those autopsied, aPL were not associated with pathologically confirmed brain infarcts, or cerebral atherosclerosis or arteriolosclerosis (all <i>p</i>≥ 0.447). <b><i>Conclusions:</i></b> In older individuals followed longitudinally, aPL do not relate to cognitive or motor decline, inflammation, or cerebrovascular disease on in vivo neuroimaging or postmortem neuropathology.
DOI: 10.6084/m9.figshare.21067291.v1
title: Breast Cancer Screening Data Final.xlsx

description: This dataset represents a retrospective review of diagnostic and therapeutic measures of breat cancer care among white non-hispanic patients versus minority patients. We retrospectively examined 100 women in five categories of breast cancer care between 1/2017 - 12/2020 – (1) Screening to Diagnostic Imaging, (2) Screening to Biopsy, (3) Biopsy to Cancer Specialist Office Visit, (4) Biopsy to Treatment Initiation, and (5) Cancer Specialist Office Visit to Treatment Initiation. <br>
DOI: 10.6084/m9.figshare.21922554.v1
title: Supplementary Material for: The Clinical and Mutational Spectrum of 69 Turkish Children with Autosomal Recessive or Autosomal Dominant Polycystic Kidney Disease: A Multicenter Retrospective Cohort Study

description: <b><i>Introduction:</i></b> Autosomal recessive polycystic kidney disease (ARPKD) is associated with pathogenic variants in the <i>PKHD1</i> gene. Autosomal dominant polycystic kidney disease (ADPKD) is mainly associated with pathogenic variants in <i>PKD1</i> or <i>PKD2</i>. The present study aimed to identify the clinical and genetic features of Turkish pediatric ARPKD and ADPKD patients. <b><i>Methods:</i></b> This multicenter, retrospective cohort study included 21 genetically confirmed ARPKD and 48 genetically confirmed ADPKD patients from 7 pediatric nephrology centers. Demographic features, clinical, and laboratory findings at presentation and during 12-month intervals were recorded. <b><i>Results:</i></b> The median age of the ARPKD patients at diagnosis was lower than the median age of ADPKD patients (10.5 months [range: 0–15 years] vs. 5.2 years [range: 0.1–16 years], respectively, [<i>p</i> = 0.014]). At the time of diagnosis, the median eGFR in the ARPKD patients was lower compared to that of ADPKD patients (81.6 [IQR: 28.7–110.5] mL/min/1.73 m<sup>2</sup> and 118 [IQR: 91.2–139.8] mL/min/1.73 m<sup>2</sup>, respectively, [<i>p</i> = 0.0001]). In total, 11 (52.4%) ARPKD patients had malnutrition; 7 (33.3%) patients had growth retardation at presentation; and 4 (19%) patients had both malnutrition and growth retardation. At diagnosis, 8 (16.7%) of the ADPKD patients had malnutrition, and 5 (10.4%) patients had growth retardation. The malnutrition, growth retardation, and hypertension rates at diagnosis were higher in the ARPKD patients than the ADPKD patients (<i>p</i> = 0.002, <i>p</i> = 0.02, and <i>p</i> = 0.0001, respectively). ARPKD patients with malnutrition and growth retardation had worse renal survival compared to the patients without (<i>p</i> = 0.03 and <i>p</i> = 0.01). Similarly, ADPKD patients with malnutrition had worse renal survival compared to the patients without (<i>p</i> = 0.002). ARPKD patients with truncating variants had poorer 3- and 6-year renal outcome than those carrying non-truncating variants (<i>p</i> = 0.017). <b><i>Conclusion:</i></b> Based on renal survival analysis, type of genetic variant, growth retardation, and/or malnutrition at presentation were observed to be factors associated with progression to chronic kidney disease (CKD). Differentiation of ARPKD and ADPKD, and identification of the predictors of the development of CKD are vital for optimal management of patients with ARPKD or ADPKD.