cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16877147
title: Evaluation of the analgesic potential and safety of <i>Cinnamomum camphora</i> chvar. <i>Borneol</i> essential oil

description: <i>Cinnamomum camphora</i> chvar. <i>Borneol</i> essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn’s method and the Draize test revealed a gender difference in mice regarding acute oral LD<sub>50</sub>, i.e., low-toxicity to female mice (2749 mg/kg), but practically nontoxic to male mice (5081 mg/kg). There was no acute and skin or eye irritation when BEO was applied directly, if the BEO concentration was less than 50%. The analgesic effect of BEO was evaluated by the glacial acetic acid-induced writhing pain model. Continuous topical application of BEO to the abdomen of mice for 6 d, significantly reduced observed writhing in mice (<i>p</i> &lt; 0.001) with a strong dose-response relationship (r = −0.9006). Concomitantly, the levels of the serum pain-related mediators, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and transient receptor potential melastatin-8 (TRPM8) were significantly reduced (<i>p</i> &lt; 0.001), and the latter showed a strong dose-response relationship (r = −0.9427). Therefore, BEO had similar analgesic functions to borneol and was demonstrated to be safe for medicinal use.
DOI: 10.25582/data.2023-01.2722558/2291535
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.16877147.v1
title: Evaluation of the analgesic potential and safety of <i>Cinnamomum camphora</i> chvar. <i>Borneol</i> essential oil

description: <i>Cinnamomum camphora</i> chvar. <i>Borneol</i> essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn’s method and the Draize test revealed a gender difference in mice regarding acute oral LD<sub>50</sub>, i.e., low-toxicity to female mice (2749 mg/kg), but practically nontoxic to male mice (5081 mg/kg). There was no acute and skin or eye irritation when BEO was applied directly, if the BEO concentration was less than 50%. The analgesic effect of BEO was evaluated by the glacial acetic acid-induced writhing pain model. Continuous topical application of BEO to the abdomen of mice for 6 d, significantly reduced observed writhing in mice (<i>p</i> &lt; 0.001) with a strong dose-response relationship (r = −0.9006). Concomitantly, the levels of the serum pain-related mediators, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and transient receptor potential melastatin-8 (TRPM8) were significantly reduced (<i>p</i> &lt; 0.001), and the latter showed a strong dose-response relationship (r = −0.9427). Therefore, BEO had similar analgesic functions to borneol and was demonstrated to be safe for medicinal use.
DOI: 10.6084/m9.figshare.7439966
title: Additional file 5: of Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7â cM and refined a region for late leaf spot resistance traits to 0.38â cM on linkage group A05 in peanut (Arachis hypogaea L.)

description: Table S3. MQTLs for yield and disease resistance identified by meta-analysis. (XLSX 17â kb)
DOI: 10.6084/m9.figshare.7439966.v1
title: Additional file 5: of Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7â cM and refined a region for late leaf spot resistance traits to 0.38â cM on linkage group A05 in peanut (Arachis hypogaea L.)

description: Table S3. MQTLs for yield and disease resistance identified by meta-analysis. (XLSX 17â kb)
DOI: 10.25582/data.2023-02.2732050/2291536
title: Data for EMSL Project 51287 from February 2023
DOI: 10.6084/m9.figshare.19498591
title: Additional file 8 of CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway

description: Additional file 8: Table S1. Primer sequences for indicated genes tested by qRT-PCR.
DOI: 10.6084/m9.figshare.19498591.v1
title: Additional file 8 of CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway

description: Additional file 8: Table S1. Primer sequences for indicated genes tested by qRT-PCR.
DOI: 10.25549/usctheses-ouc11288078
title: REMLAND-P-EDITED
DOI: 10.25582/data.2023-01.2722599/2291537
title: Data for EMSL Project 51287 from January 2023
DOI: 10.25582/data.2023-02.2726465/2291538
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-02.2731544/2291539
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-02.2731761/2291540
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-01.2718327/2291541
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.13207150
title: Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies

description: Early developmental environment can influence long-term health through reprogramming of the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such as blood, to assess the effects of environment on disease-relevant but inaccessible target tissues. However, the extent to which environment-induced epigenetic changes are conserved between these tissues is unclear. A better understanding of this conservation is imperative for effective design and interpretation of human environmental epigenetics studies. The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET II) consortium was established by the National Institute of Environmental Health Sciences to address the utility of surrogate tissues as proxies for toxicant-induced epigenetic changes in target tissues. We and others have recently reported that perinatal exposure to lead (Pb) is associated with adverse metabolic outcomes. Here, we investigated the sex-specific effects of perinatal exposure to a human environmentally relevant level of Pb on DNA methylation in paired liver and blood samples from adult mice using enhanced reduced-representation bisulphite sequencing. Although Pb exposure ceased at 3 weeks of age, we observed thousands of sex-specific differentially methylated cytosines in the blood and liver of Pb-exposed animals at 5 months of age, including 44 genomically imprinted loci. We observed significant tissue overlap in the genes mapping to differentially methylated cytosines. A small but significant subset of Pb-altered genes exhibit basal sex differences in gene expression in the mouse liver. Collectively, these data identify potential molecular targets for Pb-induced metabolic diseases, and inform the design of more robust human environmental epigenomics studies.
DOI: 10.25582/data.2023-01.2716620/2291542
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.13207150.v2
title: Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies

description: Early developmental environment can influence long-term health through reprogramming of the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such as blood, to assess the effects of environment on disease-relevant but inaccessible target tissues. However, the extent to which environment-induced epigenetic changes are conserved between these tissues is unclear. A better understanding of this conservation is imperative for effective design and interpretation of human environmental epigenetics studies. The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET II) consortium was established by the National Institute of Environmental Health Sciences to address the utility of surrogate tissues as proxies for toxicant-induced epigenetic changes in target tissues. We and others have recently reported that perinatal exposure to lead (Pb) is associated with adverse metabolic outcomes. Here, we investigated the sex-specific effects of perinatal exposure to a human environmentally relevant level of Pb on DNA methylation in paired liver and blood samples from adult mice using enhanced reduced-representation bisulphite sequencing. Although Pb exposure ceased at 3 weeks of age, we observed thousands of sex-specific differentially methylated cytosines in the blood and liver of Pb-exposed animals at 5 months of age, including 44 genomically imprinted loci. We observed significant tissue overlap in the genes mapping to differentially methylated cytosines. A small but significant subset of Pb-altered genes exhibit basal sex differences in gene expression in the mouse liver. Collectively, these data identify potential molecular targets for Pb-induced metabolic diseases, and inform the design of more robust human environmental epigenomics studies.
DOI: 10.6084/m9.figshare.13207150.v1
title: Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies

description: Early developmental environment can influence long-term health through reprogramming of the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such as blood, to assess the effects of environment on disease-relevant but inaccessible target tissues. However, the extent to which environment-induced epigenetic changes are conserved between these tissues is unclear. A better understanding of this conservation is imperative for effective design and interpretation of human environmental epigenetics studies. The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET II) consortium was established by the National Institute of Environmental Health Sciences to address the utility of surrogate tissues as proxies for toxicant-induced epigenetic changes in target tissues. We and others have recently reported that perinatal exposure to lead (Pb) is associated with adverse metabolic outcomes. Here, we investigated the sex-specific effects of perinatal exposure to a human environmentally relevant level of Pb on DNA methylation in paired liver and blood samples from adult mice using enhanced reduced-representation bisulphite sequencing. Although Pb exposure ceased at 3 weeks of age, we observed thousands of sex-specific differentially methylated cytosines in the blood and liver of Pb-exposed animals at 5 months of age, including 44 genomically imprinted loci. We observed significant tissue overlap in the genes mapping to differentially methylated cytosines. A small but significant subset of Pb-altered genes exhibit basal sex differences in gene expression in the mouse liver. Collectively, these data identify potential molecular targets for Pb-induced metabolic diseases, and inform the design of more robust human environmental epigenomics studies.
DOI: 10.6084/m9.figshare.7439984
title: Additional file 6: of Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7â cM and refined a region for late leaf spot resistance traits to 0.38â cM on linkage group A05 in peanut (Arachis hypogaea L.)

description: Table S4. Summary of MQTL hotspots on linkage group A05. (XLSX 14â kb)
DOI: 10.25582/data.2023-01.2718360/2291543
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.7439984.v1
title: Additional file 6: of Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7â cM and refined a region for late leaf spot resistance traits to 0.38â cM on linkage group A05 in peanut (Arachis hypogaea L.)

description: Table S4. Summary of MQTL hotspots on linkage group A05. (XLSX 14â kb)
DOI: 10.25582/data.2023-02.2731868/2291544
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-02.2731988/2291545
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-01.2713534/2291546
title: Data for EMSL Project 51287 from January 2023
DOI: 10.25582/data.2023-01.2718165/2291547
title: Data for EMSL Project 51287 from January 2023
DOI: 10.25582/data.2023-01.2711883/2291548
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.7439999
title: Additional file 7: of Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7â cM and refined a region for late leaf spot resistance traits to 0.38â cM on linkage group A05 in peanut (Arachis hypogaea L.)

description: Table S5. Summary of 38 candidate genes of cluster CMQTL7 for yield related traits. (XLSX 16â kb)
DOI: 10.6084/m9.figshare.7439999.v1
title: Additional file 7: of Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7â cM and refined a region for late leaf spot resistance traits to 0.38â cM on linkage group A05 in peanut (Arachis hypogaea L.)

description: Table S5. Summary of 38 candidate genes of cluster CMQTL7 for yield related traits. (XLSX 16â kb)
DOI: 10.25582/data.2023-01.2720823/2291549
title: Data for EMSL Project 51287 from January 2023
DOI: 10.25582/data.2023-02.2731718/2291550
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-01.2720702/2291551
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.7964306
title: Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA

description: Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWI proteins for transposon silencing via DNA methylation and are highly expressed and extensively studied in the germline. Mature germline piRNAs typically consist of 24–32 nucleotides, with a strong preference for a 5ʹ uridine signature, an adenosine signature at position 10, and a 2ʹ-O-methylation signature at the 3ʹ end. piRNA presence in somatic tissues, however, is not well characterized and requires further systematic evaluation. In the current study, we identified piRNAs and associated machinery from mouse somatic tissues representing the three germ layers. piRNA specificity was improved by combining small RNA size selection, sodium periodate treatment enrichment for piRNA over other small RNA, and small RNA next-generation sequencing. We identify <i>PIWIL1, PIWIL2</i>, and <i>PIWIL4</i> expression in brain, liver, kidney, and heart. Of note, somatic piRNAs are shorter in length and tissue-specific, with increased occurrence of unique piRNAs in hippocampus and liver, compared to the germline. Hippocampus contains 5,494 piRNA-like peaks, the highest expression among all tested somatic tissues, followed by cortex (1,963), kidney (580), and liver (406). The study identifies 26 piRNA sequence species and 40 piRNA locations exclusive to all examined somatic tissues. Although piRNA expression has long been considered exclusive to the germline, our results support that piRNAs are expressed in several somatic tissues that may influence piRNA functions in the soma. Once confirmed, the PIWI/piRNA system may serve as a potential tool for future research in epigenome editing to improve human health by manipulating DNA methylation.
DOI: 10.6084/m9.figshare.19498594
title: Additional file 1 of Prediction of low Apgar score at five minutes following labor induction intervention in vaginal deliveries: machine learning approach for imbalanced data at a tertiary hospital in North Tanzania

description: Additional file 1.
DOI: 10.6084/m9.figshare.19498594.v1
title: Additional file 1 of Prediction of low Apgar score at five minutes following labor induction intervention in vaginal deliveries: machine learning approach for imbalanced data at a tertiary hospital in North Tanzania

description: Additional file 1.
DOI: 10.6084/m9.figshare.7964306.v1
title: Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA

description: Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWI proteins for transposon silencing via DNA methylation and are highly expressed and extensively studied in the germline. Mature germline piRNAs typically consist of 24–32 nucleotides, with a strong preference for a 5ʹ uridine signature, an adenosine signature at position 10, and a 2ʹ-O-methylation signature at the 3ʹ end. piRNA presence in somatic tissues, however, is not well characterized and requires further systematic evaluation. In the current study, we identified piRNAs and associated machinery from mouse somatic tissues representing the three germ layers. piRNA specificity was improved by combining small RNA size selection, sodium periodate treatment enrichment for piRNA over other small RNA, and small RNA next-generation sequencing. We identify <i>PIWIL1, PIWIL2</i>, and <i>PIWIL4</i> expression in brain, liver, kidney, and heart. Of note, somatic piRNAs are shorter in length and tissue-specific, with increased occurrence of unique piRNAs in hippocampus and liver, compared to the germline. Hippocampus contains 5,494 piRNA-like peaks, the highest expression among all tested somatic tissues, followed by cortex (1,963), kidney (580), and liver (406). The study identifies 26 piRNA sequence species and 40 piRNA locations exclusive to all examined somatic tissues. Although piRNA expression has long been considered exclusive to the germline, our results support that piRNAs are expressed in several somatic tissues that may influence piRNA functions in the soma. Once confirmed, the PIWI/piRNA system may serve as a potential tool for future research in epigenome editing to improve human health by manipulating DNA methylation.
DOI: 10.25582/data.2023-01.2720939/2291552
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.23692910
title: Additional file 1 of A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

description: Additional file 1. Prioritization of functional SNPs and predication of allele-dependent TF binding
DOI: 10.6084/m9.figshare.23692910.v1
title: Additional file 1 of A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

description: Additional file 1. Prioritization of functional SNPs and predication of allele-dependent TF binding
DOI: 10.25582/data.2023-02.2731717/2291553
title: Data for EMSL Project 51287 from February 2023
DOI: 10.25582/data.2023-01.2711898/2291554
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.23692913
title: Additional file 2 of A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

description: Additional file 2. Human AGTR2 expression analysis.
DOI: 10.25582/data.2023-01.2716624/2291555
title: Data for EMSL Project 51287 from January 2023
DOI: 10.6084/m9.figshare.16877213
title: Analysis and verification of <i>N</i><sup>6</sup>-methyladenosine-modified genes as novel biomarkers for clear cell renal cell carcinoma

description: <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) has been involved in diverse biological processes in cancer, but its function and clinical value in clear cell renal cell carcinoma (ccRCC) remain largely unknown. In this study, we found that 1453 m<sup>6</sup>A-modified differentially expressed genes (DEGs) of ccRCC were mainly enriched in cell cycle, PI3K-AKT, and p53 signaling pathways. Then we constructed a co-expression network of the 1453 m<sup>6</sup>A-modified DEGs and identified a most clinically relevant module, where NUF2, CDCA3, CKAP2L, KIF14, and ASPM were hub genes. NUF2, CDCA3, and KIF14 could combine with a major RNA m<sup>6</sup>A methyltransferase METTL14, serving as biomarkers for ccRCC. Real-time quantitative PCR assay confirmed that NUF2, CDCA3, and KIF14 were highly expressed in ccRCC cell lines and ccRCC tissues. Furthermore, these three genes were modified by m<sup>6</sup>A and negatively regulated by METTL14. This study revealed that NUF2, CDCA3, and KIF14 were m<sup>6</sup>A-modified biomarkers, representing a potential diagnostic, prognostic, and therapeutic target for ccRCC. <b>Abbreviations:</b> m<sup>6</sup>A: <i>N</i><sup>6</sup>-methyladenosine; ccRCC: clear cell renal cell carcinoma; DEGs: differentially expressed genes; NUF2: NUF2 component of NDC80 kinetochore complex; CDCA3: cell division cycle associated 3; CKAP2L: cytoskeleton associated protein 2 like; KIF14: kinesin family member 14; ASPM: assembly factor for spindle microtubules; METTL14: methyltransferase 14; OS: overall survival; FPKM: fragments per kilobase million; GEO: gene expression omnibus; TCGA: the Cancer Genome Atlas; RMA: robust multi-array average expression measure; WGCNA: weighted gene co-expression network analysis; GO: gene ontology; KEGG: kyoto encyclopedia of genes and genomes; ROC: receiver operating characteristic curve; AUC: area under the curve; RIP: RNA immunoprecipitation; qPCR: real-time quantitative PCR.
DOI: 10.6084/m9.figshare.23692913.v1
title: Additional file 2 of A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

description: Additional file 2. Human AGTR2 expression analysis.
DOI: 10.15468/dl.5yr24u
title: Occurrence Download

description: A dataset containing 151 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ozoroa mucronata (Bernh. ex Krauss) R.Fern. & A.Fern."
 ]
}

 The dataset includes 151 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065386-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.s3dkqq
title: Occurrence Download

description: A dataset containing 54 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Panicum humbertii A.Camus"
 ]
}

 The dataset includes 54 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065385-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xg3te6
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Othonna purpurascens Harv."
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065387-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vv8yma
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Paronychia pontica (Borhidi) Chaudhri"
 ]
}

 The dataset includes 4 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065388-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.chqa6g
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Osbeckia lanata Alston"
 ]
}

 The dataset includes 71 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065390-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.76yhs9
title: Occurrence Download

description: A dataset containing 76 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Othonna quercifolia DC."
 ]
}

 The dataset includes 76 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065393-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.