DOI: 10.5061/dryad.0r4d0
title: Data from: The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogaster

description: Sex differences in ageing and lifespan are ubiquitous in nature. The
 "unguarded-X” hypothesis (UXh) suggests they may be partly due to the
 expression of recessive mutations in the hemizygous sex chromosomes of the
 heterogametic sex, which could help explain sex-specific ageing in a broad
 array of taxa. A prediction central to the UX hypothesis is that
 inbreeding will decrease the lifespan of the homogametic sex more than the
 heterogametic sex, because only in the former does inbreeding increase the
 expression of recessive deleterious mutations. In this study, we test this
 prediction by examining the effects of inbreeding on the lifespan and
 fitness of male and female Drosophila melanogaster across different social
 environments. We found that, across social environments, inbreeding
 resulted in a greater reduction of female than male lifespan, and that
 inbreeding effects on fitness did not seem to counterbalance sex-specific
 effects on lifespan, suggesting the former are maladaptative. Inter- and
 intra-sexual correlation analyses also allowed us to identify evidence of
 an underlying joint genetic architecture for inbreeding effects on
 lifespan. We discuss these results in light of the UXh and other
 alternative explanations, and suggest that more attention should be paid
 to the possibility that the “unguarded-X” may play an important role in
 the evolution of sex-specific lifespan.
description: Lifespan
 DataLifespan data for the
 manuscript accepted in Evolution titled as: "The “unguarded-X” and
 the genetic architecture of lifespan: Inbreeding results in a potentially
 maladaptive sex-specific reduction of female lifespan in Drosophila
 melanogaster". It also contains data from a previous experiment with
 the same design (Carazo P, Green J, Sepil I, Pizzari T, Wigby S (2016)
 Inbreeding removes sex differences in lifespan in a population of
 Drosophila melanogaster. Biology Letters 12(6): 20160337.). In the csv
 file the variables are as follows: ID (identification name for each
 isoline), LS (lifespan in days), IBR (inbreeding treatment), SE (social
 environment), SEX and finally EXP (name of the experiment, A is the one
 done by Carazo et al 2016 and B is the current
 experiment).data_lifespan_combined.csvFitness DataFitness data for the manuscript accepted in Evolution titled as: "The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogaster". In the csv file the variables are as follows: ID (identification name for each isoline), IBR (inbreeding treatment), SRS (standardized reproductive success) and Sex.data_fitness.csvLifespan Data (inbred and outbred)Inbred/Outbred lifespan data for the manuscript accepted in Evolution titled as: "The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogaster". It also contains data from a previous experiment with the same design (Carazo P, Green J, Sepil I, Pizzari T, Wigby S (2016) Inbreeding removes sex differences in lifespan in a population of Drosophila melanogaster. Biology Letters 12(6): 20160337.). In the csv file the variables are as follows: Experiment (as the name of the experiment, A is the one done by Carazo et al 2016 and B is the current experiment), ID (identification name for each isoline), Sex, LSib (inbred lifespan in days), LSob (outbred lifespan in days), SE (Social Environment)LF_inoutbred.csvLifespan Data (Male and Female)Male/Female lifespan data for the manuscript accepted in Evolution titled as: "The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogaster". It also contains data from a previous experiment with the same design (Carazo P, Green J, Sepil I, Pizzari T, Wigby S (2016) Inbreeding removes sex differences in lifespan in a population of Drosophila melanogaster. Biology Letters 12(6): 20160337.). In the csv file the variables are as follows: Experiment (as the name of the experiment, A is the one done by Carazo et al 2016 and B is the current experiment), ID (identification name for each isoline), Inbreeding (the inbreeding treatment, LSm (male lifespan in days), LSf (female lifespan in days), SE (Social Environment).LF_malefemale.csvID in lifespan dataInbreeding depression in lifespan data for the manuscript accepted in Evolution titled as: "The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogaster". It also contains data from a previous experiment with the same design (Carazo P, Green J, Sepil I, Pizzari T, Wigby S (2016) Inbreeding removes sex differences in lifespan in a population of Drosophila melanogaster. Biology Letters 12(6): 20160337.). In the csv file the variables are as follows: Experiment (as the name of the experiment, A is the one done by Carazo et al 2016 and B is the current experiment), ID (identification name for each isoline), SE (Social Environment), dLSf (decrease due to inbreeding for females), dLSm (decrease due to inbreeding for females).DeltaLF.csv