cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.10473097
title: Development, Optimization and In Vitro Evaluation of Buccal Tablet of Posaconazole

description: Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate Mucoadhesive buccal tablet using Posaconazole and compatible excipients, and to evaluate the product using quality control tests and in vitro tests. In the development of buccal tablet of antifungal drug Posaconazole to treat oral thrush locally and to improve the solubility and bioavailability of drug, simultaneously enhances the erosion rate of tablet Mucoadhesive dosage forms have long been employed to improve the bioavailability of drugs undergoing significant hepatic first-pass metabolism and control the release of drugs from hydrophilic matrices. Therefore, it is needed to develop suitable controlled release Mucoadhesive buccal tablets containing an antifungal agent, Posaconazole. The present study has been planned to formulate the Mucoadhesive buccal tablets of posaconazole by using xanthan gum and carbopol 940. This formulation used for the treatment of oral candidiasis. In vitro drug release results of all the formulations were conducted for 12 h which indicated that, tablet formulations, F1- F9 were found to be following non- fickian diffusion. The formulation F5 was taken as an optimized batch. Stability studies were conducted at 400C and 75 % RH as per ICH guidelines.
DOI: 10.5281/zenodo.10473098
title: Development, Optimization and In Vitro Evaluation of Buccal Tablet of Posaconazole

description: Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate Mucoadhesive buccal tablet using Posaconazole and compatible excipients, and to evaluate the product using quality control tests and in vitro tests. In the development of buccal tablet of antifungal drug Posaconazole to treat oral thrush locally and to improve the solubility and bioavailability of drug, simultaneously enhances the erosion rate of tablet Mucoadhesive dosage forms have long been employed to improve the bioavailability of drugs undergoing significant hepatic first-pass metabolism and control the release of drugs from hydrophilic matrices. Therefore, it is needed to develop suitable controlled release Mucoadhesive buccal tablets containing an antifungal agent, Posaconazole. The present study has been planned to formulate the Mucoadhesive buccal tablets of posaconazole by using xanthan gum and carbopol 940. This formulation used for the treatment of oral candidiasis. In vitro drug release results of all the formulations were conducted for 12 h which indicated that, tablet formulations, F1- F9 were found to be following non- fickian diffusion. The formulation F5 was taken as an optimized batch. Stability studies were conducted at 400C and 75 % RH as per ICH guidelines.
DOI: 10.5281/zenodo.10471348
title: Site Identification Analysis for AWE Devices. A case study in Germany

description: Airborne Wind Energy Systems (AWES) use kites and gliders to harvest renewable energy from high-altitude winds, offering a complimentary technology for achieving a Global Net Zero emissions targets. Implementation of these systems involves complexities and characteristics that cannot (necessarily) be generalized within studies of typical wind turbines. Therefore, it is important to adopt adequate approaches to conduct site selection studies that are suited for both pilot testing and operations at a commercial scale for the different devices currently under development. 

As part of the MegaAWE project (supported by Interreg North-Western Europe), a site identification analysis for AWE devices was carried out following a technology-agnostic approach, using Germany as a case study. Several technological, geographical, environmental, and political criteria were defined and a thorough analysis using GIS tools was carried out to identify the suitable areas for the deployment of this technology under different scenarios. Three case studies were applied to the width of the Risk Buffer (RB), the Operational Radius (OR) and the distance from the Ground station to Forests (F).

Understanding the potential capacity of AWEs is essential for assessing the feasibility and economic viability of deploying AWE technologies. 

The results of the identified deployment and operational areas for AWES in Germany are available in shapefile format. Name code:



Deployment Areas. Refers to the areas where the Ground Stations of each device can be deployed.

Operational Areas. Includes both the deployment areas and the zones where the devices would be actively flying. 

RBxxx. 'RB' stands for Risk Buffer and xxx for the width applied in each scenario.

ORxxx. 'OR' stands for Operational Radius, and xxx indicates the longitude applied.

Fxxx. 'F' stands for Forests and xxx indicates the distance from the ground station to Forests. 

3035. Indicates the layer projection (EPSG:3035 (ETRS89, LAEA)).


Additionally, this analysis allowed for the comparison with other established technologies (i.e., traditional wind turbines). Results can be found in the layers named "Deployment/Operational_Areas_Exclusive_AWE..."

Documentation on methods, input data and results analysis are available here - DOI: 10.5281/zenodo.10462306
DOI: 10.5281/zenodo.10471349
title: Site Identification Analysis for AWE Devices. A case study in Germany

description: Airborne Wind Energy Systems (AWES) use kites and gliders to harvest renewable energy from high-altitude winds, offering a complimentary technology for achieving a Global Net Zero emissions targets. Implementation of these systems involves complexities and characteristics that cannot (necessarily) be generalized within studies of typical wind turbines. Therefore, it is important to adopt adequate approaches to conduct site selection studies that are suited for both pilot testing and operations at a commercial scale for the different devices currently under development. 

As part of the MegaAWE project (supported by Interreg North-Western Europe), a site identification analysis for AWE devices was carried out following a technology-agnostic approach, using Germany as a case study. Several technological, geographical, environmental, and political criteria were defined and a thorough analysis using GIS tools was carried out to identify the suitable areas for the deployment of this technology under different scenarios. Three case studies were applied to the width of the Risk Buffer (RB), the Operational Radius (OR) and the distance from the Ground station to Forests (F).

Understanding the potential capacity of AWEs is essential for assessing the feasibility and economic viability of deploying AWE technologies. 

The results of the identified deployment and operational areas for AWES in Germany are available in shapefile format. Name code:



Deployment Areas. Refers to the areas where the Ground Stations of each device can be deployed.

Operational Areas. Includes both the deployment areas and the zones where the devices would be actively flying. 

RBxxx. 'RB' stands for Risk Buffer and xxx for the width applied in each scenario.

ORxxx. 'OR' stands for Operational Radius, and xxx indicates the longitude applied.

Fxxx. 'F' stands for Forests and xxx indicates the distance from the ground station to Forests. 

3035. Indicates the layer projection (EPSG:3035 (ETRS89, LAEA)).


Additionally, this analysis allowed for the comparison with other established technologies (i.e., traditional wind turbines). Results can be found in the layers named "Deployment/Operational_Areas_Exclusive_AWE..."

Documentation on methods, input data and results analysis are available here - DOI: 10.5281/zenodo.10462306
DOI: 10.6084/m9.figshare.21677687.v2
title: Version 2 of the global ocean diazotroph database

description: This is a second version of marine diazotroph database, including nitrogen fixation rates, cell-count-based abundance and <em>nifH</em>-based abundance.
DOI: 10.6084/m9.figshare.24966540
title: Supplementary Material for: Tuberculous Meningitis Presenting with Bilateral Optic Neuritis: A Case Report and Review of Literature

description: Introduction: Tuberculosis (TB) is a major global cause of morbidity and mortality. Tuberculous meningitis (TBM) is an implication of systemic dissemination of a primary TB infection that indicates a poorer disease prognosis with various long term neurological sequalae. Consequently, it is crucial to understand different clinical presentations and manifestations of such condition. In TBM, vision loss, which is one of the most devastating complications, may result from optic nerve inflammation and atrophy. Although unilateral optic neuritis as a primary presenting symptom of TBM has been broadly reported in the literature, there is paucity of information related to several other rare neuro-ophthalmic features, such as bilateral optic nerve involvement in TBM.
Case presentation: We herein present a case of a 37 years-old Indian male patient presenting with unilateral vision loss that subsequently progressed to bilateral vision loss and was hence diagnosed with bilateral optic neuritis. Additional thorough investigation yielded a diagnosis of TBM with underlying tuberculomas. The patient’s condition improved afterwards with anti-tuberculous therapy and steroids with a follow up magnetic resonance imaging indicating radiological resolution as well. 
Conclusion: The differential diagnosis of bilateral optic neuritis is broad but a rare, yet an overlooked one would be central nervous system TB in form of meningitis or tuberculoma. Hence, it is important to identify bilateral optic neuritis as a possible rare presenting symptom of an underlying central nervous system TB infection which could lead to a faster disease diagnosis and treatment to prevent its devastating complications.
DOI: 10.6084/m9.figshare.24966540.v1
title: Supplementary Material for: Tuberculous Meningitis Presenting with Bilateral Optic Neuritis: A Case Report and Review of Literature

description: Introduction: Tuberculosis (TB) is a major global cause of morbidity and mortality. Tuberculous meningitis (TBM) is an implication of systemic dissemination of a primary TB infection that indicates a poorer disease prognosis with various long term neurological sequalae. Consequently, it is crucial to understand different clinical presentations and manifestations of such condition. In TBM, vision loss, which is one of the most devastating complications, may result from optic nerve inflammation and atrophy. Although unilateral optic neuritis as a primary presenting symptom of TBM has been broadly reported in the literature, there is paucity of information related to several other rare neuro-ophthalmic features, such as bilateral optic nerve involvement in TBM.
Case presentation: We herein present a case of a 37 years-old Indian male patient presenting with unilateral vision loss that subsequently progressed to bilateral vision loss and was hence diagnosed with bilateral optic neuritis. Additional thorough investigation yielded a diagnosis of TBM with underlying tuberculomas. The patient’s condition improved afterwards with anti-tuberculous therapy and steroids with a follow up magnetic resonance imaging indicating radiological resolution as well. 
Conclusion: The differential diagnosis of bilateral optic neuritis is broad but a rare, yet an overlooked one would be central nervous system TB in form of meningitis or tuberculoma. Hence, it is important to identify bilateral optic neuritis as a possible rare presenting symptom of an underlying central nervous system TB infection which could lead to a faster disease diagnosis and treatment to prevent its devastating complications.
DOI: 10.6084/m9.figshare.24966903
title: English Transcript

description: This is the English translation for my interviews
DOI: 10.6084/m9.figshare.24966903.v1
title: English Transcript

description: This is the English translation for my interviews
DOI: 10.6084/m9.figshare.24155730.v1
title: Size spectra support a strong trophic amplification of marine biomass declines

description: Global meta-analysis of slopes of plankton size spectra: Data behind Figs1-5
DOI: 10.6084/m9.figshare.24155730
title: Size spectra support a strong trophic amplification of marine biomass declines

description: Global meta-analysis of slopes of plankton size spectra: Data behind Figs1-5
DOI: 10.6084/m9.figshare.22800245
title: Cycling life of the solid-state batteries

description: Long-term cycling performance of the SPAN|SPEs|Li at 0.3 C.
DOI: 10.4121/68377ee4-892d-40f0-a490-29f2601e6825
title: Coastgons: regional coastal characteristics along a global hexagonal coastline grid

description: This dataset contains the global coastgon grid, covering the Earth's coastline between -37 and 48 degrees latitude in a hexagonal cell grid. Each Coastgon (hexagonal coastal cell) has a diameter of around 50 km (although this varies with almost all Coastgon diameters between 45 and 55 km). Each coastgon is characterized by 22 coastal indicators derived from state-of-the-art global datasets, spanning hydrodynamic, atmospheric, geophysical, habitat, and human processes. For more details on the derivation and background of the data, the reader is refered to the accompanying publication:<br>Christiaanse, J.C., Antolínez, J.A.A., Luijendijk, A.P., Athanasiou, P., Duarte, C.M., and Aarninkhof, S. (2024). Distribution of global sea turtle nesting explained from regional-scale coastal characteristics. <em>Scientific Reports, 14(752)</em>. https://doi.org/10.1038/s41598-023-50239-5
DOI: 10.4121/68377ee4-892d-40f0-a490-29f2601e6825.v2
title: Coastgons: regional coastal characteristics along a global hexagonal coastline grid

description: This dataset contains the global coastgon grid, covering the Earth's coastline between -37 and 48 degrees latitude in a hexagonal cell grid. Each Coastgon (hexagonal coastal cell) has a diameter of around 50 km (although this varies with almost all Coastgon diameters between 45 and 55 km). Each coastgon is characterized by 22 coastal indicators derived from state-of-the-art global datasets, spanning hydrodynamic, atmospheric, geophysical, habitat, and human processes. For more details on the derivation and background of the data, the reader is refered to the accompanying publication:<br>Christiaanse, J.C., Antolínez, J.A.A., Luijendijk, A.P., Athanasiou, P., Duarte, C.M., and Aarninkhof, S. (2024). Distribution of global sea turtle nesting explained from regional-scale coastal characteristics. <em>Scientific Reports, 14(752)</em>. https://doi.org/10.1038/s41598-023-50239-5
DOI: 10.5281/zenodo.10071421
title: Martyr Dramas 15-1700

description: This is a catalogue of martyr dramas written and published between 1500 and 1700.

Minimal definition of martyr drama as a literary genre: A text written in the dramatic mode which represents the exemplary death of an individual who is considered holy by a Christian community.

Background of the Publication: This catalogue is an appendix to my PhD thesis "Between Calvary and Parnussus. A Literary History of the Early Modern Martyr Drama", handed in at the Department of Arts and Cultural Studies, University of Copenhagen, January 2024.

For further explanation of the catalogue, cf. the 'Explanation' sheet within the file.
DOI: 10.18112/openneuro.ds004907.v1.1.1
title: RestHoldMove
DOI: 10.6084/m9.figshare.23695644
title: Thermal biology of aquatic insects in alpine lakes: insights from diving beetles

description: Raw data of the laboratory experiments used for statistical analyses and modelling in the manuscript <em>Thermal biology of aquatic insects in alpine lakes: insights from diving beetles.</em>
DOI: 10.6084/m9.figshare.23695644.v1
title: Thermal biology of aquatic insects in alpine lakes: insights from diving beetles

description: Raw data of the laboratory experiments used for statistical analyses and modelling in the manuscript <em>Thermal biology of aquatic insects in alpine lakes: insights from diving beetles.</em>
DOI: 10.5281/zenodo.10071420
title: Martyr Dramas 15-1700

description: This is a catalogue of martyr dramas written and published between 1500 and 1700.

Minimal definition of martyr drama as a literary genre: A text written in the dramatic mode which represents the exemplary death of an individual who is considered holy by a Christian community.

Background of the Publication: This catalogue is an appendix to my PhD thesis "Between Calvary and Parnussus. A Literary History of the Early Modern Martyr Drama", handed in at the Department of Arts and Cultural Studies, University of Copenhagen, January 2024.

For further explanation of the catalogue, cf. the 'Explanation' sheet within the file.
DOI: 10.5281/zenodo.10473161
title: Efgartigimod: The Saviour for Autoimmune Condition

description: Efgartigimod (efgartigimodalfa-fcab, Vyvgart™) is a first-in-class neonatal Fc receptor antagonist being developed by argenx for the treatment of autoimmune diseases including myasthenia gravis. It used specifically in generalized myasthenia gravis (gMG) in adults who are anti-acetylcholine receptor (AChR) antibody positive. Efgartigimod binds to the FcRn and inhibits its interaction with IgG, thereby reducing IgG recycling and increasing degradation of IgG and pathological auto antibodies, without altering other immunoglobulins and albumin levels. This results in a reduction in overall levels of IgG, including the abnormal AChR antibodies that are present in gMG. Efgartigimod was approved by the FDA in December 2021, and is administered as a single-dose intravenous infusion. The most common side effects of efgartigimod include infusion reactions, headache, and upper respiratory tract infections. Efgartigimod is a promising new treatment for gMG, and has the potential to offer significant benefits to patients who have not responded to other treatments. Further studies are needed to assess the long-term safety and efficacy of efgartigimod.
DOI: 10.5281/zenodo.10473162
title: Efgartigimod: The Saviour for Autoimmune Condition

description: Efgartigimod (efgartigimodalfa-fcab, Vyvgart™) is a first-in-class neonatal Fc receptor antagonist being developed by argenx for the treatment of autoimmune diseases including myasthenia gravis. It used specifically in generalized myasthenia gravis (gMG) in adults who are anti-acetylcholine receptor (AChR) antibody positive. Efgartigimod binds to the FcRn and inhibits its interaction with IgG, thereby reducing IgG recycling and increasing degradation of IgG and pathological auto antibodies, without altering other immunoglobulins and albumin levels. This results in a reduction in overall levels of IgG, including the abnormal AChR antibodies that are present in gMG. Efgartigimod was approved by the FDA in December 2021, and is administered as a single-dose intravenous infusion. The most common side effects of efgartigimod include infusion reactions, headache, and upper respiratory tract infections. Efgartigimod is a promising new treatment for gMG, and has the potential to offer significant benefits to patients who have not responded to other treatments. Further studies are needed to assess the long-term safety and efficacy of efgartigimod.
DOI: 10.5281/zenodo.10473105
title: The environmental impact of energy consumption and carbon emissions in radiology departments: a systematic review

description: Objectives: Energy consumption and carbon emissions from medical equipment like CT/MRI scanners and workstations contribute to the environmental impact of healthcare facilities. The aim of this systematic review was to identify all strategies to reduce energy use and carbon emissions in radiology.

Methods: In June 2023, a systematic review (Medline/EMBASE/Web of Science) was performed to search original articles on environmental sustainability in radiology. The extracted data include environmental sustainability topics (e.g., energy consumption, carbon footprint) and radiological devices involved. Sustainable actions and environmental impact in radiology settings were analysed. Study quality was assessed using the QualSyst tool.

Results: From 918 retrieved articles, 16 met the inclusion criteria. Among them, main topics were energy consumption (10/16, 62.5%), life-cycle assessment (4/16, 25.0%), and carbon footprint (2/16, 12.5%). Eleven studies reported that 40−91% of the energy consumed by radiological devices can be defined as “nonproductive” (devices “on” but not working). Turning-off devices during idle periods 9/16 (56.2%) and implementing workflow informatic tools (2/16, 12.5%) were the sustainable actions identified. Energy-savings strategies were reported in 8/16 articles (50%), estimating annual savings of thousand kilowatt-hours (14,180−171,000 kWh). Cost-savings were identified in 7/16 (43.7%) articles, ranging from 9,225 to 14,328 US$ per device. Study quality was over or equal the 80% of high-quality level in 14/16 (87.5%) articles.

Conclusion: Energy consumption and environmental sustainability in radiology received attention in literature. Sustainable actions include turning-off radiological devices during idle periods, favoring the most energy-efficient imaging devices, and educating radiological staff on energy-saving practices, without compromising service quality.
DOI: 10.5281/zenodo.10473106
title: The environmental impact of energy consumption and carbon emissions in radiology departments: a systematic review

description: Objectives: Energy consumption and carbon emissions from medical equipment like CT/MRI scanners and workstations contribute to the environmental impact of healthcare facilities. The aim of this systematic review was to identify all strategies to reduce energy use and carbon emissions in radiology.

Methods: In June 2023, a systematic review (Medline/EMBASE/Web of Science) was performed to search original articles on environmental sustainability in radiology. The extracted data include environmental sustainability topics (e.g., energy consumption, carbon footprint) and radiological devices involved. Sustainable actions and environmental impact in radiology settings were analysed. Study quality was assessed using the QualSyst tool.

Results: From 918 retrieved articles, 16 met the inclusion criteria. Among them, main topics were energy consumption (10/16, 62.5%), life-cycle assessment (4/16, 25.0%), and carbon footprint (2/16, 12.5%). Eleven studies reported that 40−91% of the energy consumed by radiological devices can be defined as “nonproductive” (devices “on” but not working). Turning-off devices during idle periods 9/16 (56.2%) and implementing workflow informatic tools (2/16, 12.5%) were the sustainable actions identified. Energy-savings strategies were reported in 8/16 articles (50%), estimating annual savings of thousand kilowatt-hours (14,180−171,000 kWh). Cost-savings were identified in 7/16 (43.7%) articles, ranging from 9,225 to 14,328 US$ per device. Study quality was over or equal the 80% of high-quality level in 14/16 (87.5%) articles.

Conclusion: Energy consumption and environmental sustainability in radiology received attention in literature. Sustainable actions include turning-off radiological devices during idle periods, favoring the most energy-efficient imaging devices, and educating radiological staff on energy-saving practices, without compromising service quality.
DOI: 10.5281/zenodo.10042320
title: Data from: A long-standing T2R subtype unique to elasmobranchs: revisiting the origin of vertebrate bitter taste receptors

description: These files include supporting information of a paper entitled "A long-standing T2R subtype unique to elasmobranchs: revisiting the origin of vertebrate bitter taste receptors".
DOI: 10.5281/zenodo.10042321
title: Data from: A long-standing T2R subtype unique to elasmobranchs: revisiting the origin of vertebrate bitter taste receptors

description: These files include supporting information of a paper entitled "A long-standing T2R subtype unique to elasmobranchs: revisiting the origin of vertebrate bitter taste receptors".