cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12173106.v1
title: Influence of diagnosis of venous thromboembolism on immature platelets, absolute platelet count and platelet aggregation over time

description: The extent of the involvement of platelets in venous thromboembolisms (VTE) is still not fully understood. Immature platelets are large, RNA-rich, prothrombotic platelets. They are involved in arterial thromboembolisms and are associated with adverse cardiovascular events. Their role in VTE has not been investigated before. The aim of this study was to assess different platelet parameters including immature platelet fraction (IPF), immature platelet count (IPC), absolute platelet count and platelet aggregation (PA) over time in patients with VTE at time of diagnosis, as well as at 3–10 days and at 90–110 days after diagnosis. 50 healthy volunteers similar in age and sex to patients served as controls at diagnosis. IPF was measured by the Sysmex XE-5000 analyzer, PA was assessed using the Multiplate analyzer. Diagnosis of VTE had no relevant effect on IPF and IPC whereas absolute platelet count and PA were significantly decreased compared to controls. In the course of VTE, IPF decreased significantly, whereas IPC, absolute platelet count and PA increased. In conclusion, VTE was associated with relevant changes of the absolute platelet count and PA at diagnosis, as well as changes in IPF and IPC over time reflecting a relevant and measurable platelet consumption in VTEs.
DOI: 10.6084/m9.figshare.11932581
title: Lymphatic blood filling in CLEC-2-deficient mouse models

description: C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventing lymphatic vessel blood filling in mice throughout life. In this study, this aspect of CLEC-2/podoplanin function is investigated in more detail using new and established mouse models of CLEC-2 and podoplanin deficiency, and models of acute and chronic vascular remodeling. We report that CLEC-2 expression on platelets is not required to maintain a barrier between the blood and lymphatic systems in unchallenged mice, post-development. However, under certain conditions of chronic vascular remodeling, such as during tumorigenesis, deficiency in CLEC-2 can lead to lymphatic vessel blood filling. These data provide a new understanding of the function of CLEC-2 in adult mice and confirm the essential nature of CLEC-2-driven platelet activation in vascular developmental programs. This work expands our understanding of how lymphatic blood filling is prevented by CLEC-2-dependent platelet function and provides a context for the development of safe targeting strategies for CLEC-2 and podoplanin.
DOI: 10.6084/m9.figshare.12173106
title: Influence of diagnosis of venous thromboembolism on immature platelets, absolute platelet count and platelet aggregation over time

description: The extent of the involvement of platelets in venous thromboembolisms (VTE) is still not fully understood. Immature platelets are large, RNA-rich, prothrombotic platelets. They are involved in arterial thromboembolisms and are associated with adverse cardiovascular events. Their role in VTE has not been investigated before. The aim of this study was to assess different platelet parameters including immature platelet fraction (IPF), immature platelet count (IPC), absolute platelet count and platelet aggregation (PA) over time in patients with VTE at time of diagnosis, as well as at 3–10 days and at 90–110 days after diagnosis. 50 healthy volunteers similar in age and sex to patients served as controls at diagnosis. IPF was measured by the Sysmex XE-5000 analyzer, PA was assessed using the Multiplate analyzer. Diagnosis of VTE had no relevant effect on IPF and IPC whereas absolute platelet count and PA were significantly decreased compared to controls. In the course of VTE, IPF decreased significantly, whereas IPC, absolute platelet count and PA increased. In conclusion, VTE was associated with relevant changes of the absolute platelet count and PA at diagnosis, as well as changes in IPF and IPC over time reflecting a relevant and measurable platelet consumption in VTEs.
DOI: 10.6084/m9.figshare.11932581.v1
title: Lymphatic blood filling in CLEC-2-deficient mouse models

description: C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventing lymphatic vessel blood filling in mice throughout life. In this study, this aspect of CLEC-2/podoplanin function is investigated in more detail using new and established mouse models of CLEC-2 and podoplanin deficiency, and models of acute and chronic vascular remodeling. We report that CLEC-2 expression on platelets is not required to maintain a barrier between the blood and lymphatic systems in unchallenged mice, post-development. However, under certain conditions of chronic vascular remodeling, such as during tumorigenesis, deficiency in CLEC-2 can lead to lymphatic vessel blood filling. These data provide a new understanding of the function of CLEC-2 in adult mice and confirm the essential nature of CLEC-2-driven platelet activation in vascular developmental programs. This work expands our understanding of how lymphatic blood filling is prevented by CLEC-2-dependent platelet function and provides a context for the development of safe targeting strategies for CLEC-2 and podoplanin.
DOI: 10.5281/zenodo.4597530
title: Data set for phase-field studies of crystal growth in single-seal syntaxial veins in limestone

description: The data sets corresponds to the research work which will undergo a peer-review process. Only the co-authors, the editor and the reviewers can have the access to this data set until publication. The data sets will be made open access once the associated research work is published.
DOI: 10.6084/m9.figshare.13084925
title: The role of selective imidazoline receptor agonists in modern hypertension management: an international real-world survey (STRAIGHT)

description: Multiple pharmacologic strategies are currently available to lower blood pressure (BP). Renin-angiotensin system (RAS)-inhibitors, calcium channel blockers and diuretics are widely recommended as first line therapies. Sympathetic activation is an important contributor to BP elevation but remains unopposed or is even increased by some of these drug classes. Selective imidazoline receptor agonists (SIRAs) reduce increased central sympathetic outflow and are considered as add-on therapy in most guidelines. We conducted an international survey to evaluate contemporary hypertension management strategies in countries with high prescription rates of SIRAs to better understand the rationale and practical indications for their use in a real-world setting. Physicians from seven countries (India, Jordan, Lebanon, Russia, Saudi Arabia, South Africa, United Arab Emirates) were asked to complete a web-based questionnaire and comment on clinical case scenarios to provide information on their current practice regarding antihypertension strategies, underlying rationale for their choices, and adherence to relevant guidelines. 281 physicians completed the questionnaire including mainly cardiologists (35%) and general practitioners (32%). 96% reported using European (60%) or local (56%) guidelines in their daily practices. The majority of responding physicians (83%) had knowledge of SIRAs and 70% prescribed SIRAs regularly typically as a third line antihypertensive strategy (63%). The preferred combination partners for SIRAs were RAS-inhibitors (72%). Contemporary hypertension management varies between countries and therapeutic approaches in a real-world setting are not always in line with recommendations from available guidelines. In the countries selected for this survey prescription of SIRAs was common and appeared to be guided predominantly by considerations relating to the underlying pathophysiologic mechanism of sympathetic inhibition.
DOI: 10.6084/m9.figshare.13084925.v2
title: The role of selective imidazoline receptor agonists in modern hypertension management: an international real-world survey (STRAIGHT)

description: Multiple pharmacologic strategies are currently available to lower blood pressure (BP). Renin-angiotensin system (RAS)-inhibitors, calcium channel blockers and diuretics are widely recommended as first line therapies. Sympathetic activation is an important contributor to BP elevation but remains unopposed or is even increased by some of these drug classes. Selective imidazoline receptor agonists (SIRAs) reduce increased central sympathetic outflow and are considered as add-on therapy in most guidelines. We conducted an international survey to evaluate contemporary hypertension management strategies in countries with high prescription rates of SIRAs to better understand the rationale and practical indications for their use in a real-world setting. Physicians from seven countries (India, Jordan, Lebanon, Russia, Saudi Arabia, South Africa, United Arab Emirates) were asked to complete a web-based questionnaire and comment on clinical case scenarios to provide information on their current practice regarding antihypertension strategies, underlying rationale for their choices, and adherence to relevant guidelines. 281 physicians completed the questionnaire including mainly cardiologists (35%) and general practitioners (32%). 96% reported using European (60%) or local (56%) guidelines in their daily practices. The majority of responding physicians (83%) had knowledge of SIRAs and 70% prescribed SIRAs regularly typically as a third line antihypertensive strategy (63%). The preferred combination partners for SIRAs were RAS-inhibitors (72%). Contemporary hypertension management varies between countries and therapeutic approaches in a real-world setting are not always in line with recommendations from available guidelines. In the countries selected for this survey prescription of SIRAs was common and appeared to be guided predominantly by considerations relating to the underlying pathophysiologic mechanism of sympathetic inhibition.
DOI: 10.6084/m9.figshare.13084925.v1
title: The role of selective imidazoline receptor agonists in modern hypertension management - an international real-world survey (STRAIGHT)

description: <b>Background</b>: Multiple pharmacologic strategies are currently available to lower blood pressure (BP). Renin-angiotensin system (RAS)-inhibitors, calcium channel blockers and diuretics are widely recommended as first line therapies. Sympathetic activation is an important contributor to BP elevation but remains unopposed or is even increased by some of these drug classes. Selective imidazoline receptor agonists (SIRAs) reduce increased central sympathetic outflow and are considered as add-on therapy in most guidelines. We conducted an international survey to evaluate contemporary hypertension management strategies in countries with high prescription rates of SIRAs to better understand the rationale and practical indications for their use in a real-world setting. <b>Methods:</b> Physicians from seven countries (India, Jordan, Lebanon, Russia, Saudi Arabia, South Africa, United Arab Emirates) were asked to complete a web-based questionnaire and comment on clinical case scenarios to provide information on their current practice regarding antihypertension strategies, underlying rationale for their choices, and adherence to relevant guidelines. <b>Results:</b> 281 physicians completed the questionnaire including mainly cardiologists (35%) and general practitioners (32%). 96% reported using European (60%) or local (56%) guidelines in their daily practices. The majority of responding physicians (83%) had knowledge of SIRAs and 70% prescribed SIRAs regularly typically as a third line antihypertensive strategy (63%). The preferred combination partners for SIRAs were RAS-inhibitors (72%). <b>Conclusions:</b> Contemporary hypertension management varies between countries and therapeutic approaches in a real-world setting are not always in line with recommendations from available guidelines. In the countries selected for this survey prescription of SIRAs was common and appeared to be guided predominantly by considerations relating to the underlying pathophysiologic mechanism of sympathetic inhibition.
DOI: 10.6084/m9.figshare.12901669
title: Computation of electrical responsive properties and global reactivity descriptors along the proton transfer co-ordinate of donor–acceptor substituted pyrazole derivatives

description: Ground and excited-state proton transfer and electrical responsive properties along the proton transfer co-ordinate of four donor–acceptor substituted pyrazole derivatives have been investigated using the density function-based range separated hybrid GGA functional <i>ω</i>B97XD with 6-311G(d) basis. Both intrinsic reaction coordinate (IRC) and distinguished co-ordinate (variation of O–H distance of the enol tautomer) have been chosen as a proton transfer co-ordinate of the titled compounds for comparison. Our study reveals that the various electrical responsive parameters like average polarizability (<i>α</i><sub>av</sub>), first hyperpolarizability (<i>β</i><sub>av</sub>) and global reactivity descriptors e.g., chemical hardness (<i>η</i>), electrophilicity index (<i>ω</i>) along the proton transfer co-ordinate are in conformity with the respective optimum principles. Maximum value of <i>β</i><sub>av</sub> is found in the case of nitro substituted pyrazole derivative. Variation of <i>β</i><sub>av</sub> along the proton transfer co-ordinate for all compounds have been correlated with the variation of Δ<i>µf</i><sub>0</sub>/(<i>S</i><sub>1</sub>-<i>S</i><sub>0</sub>)<sup>3</sup> using two-level approximation and electronic special extent (&lt;<i>R</i><sup>2</sup>&gt;) along the proton transfer coordinate.
DOI: 10.6084/m9.figshare.12901669.v2
title: Computation of electrical responsive properties and global reactivity descriptors along the proton transfer co-ordinate of donor–acceptor substituted pyrazole derivatives

description: Ground and excited-state proton transfer and electrical responsive properties along the proton transfer co-ordinate of four donor–acceptor substituted pyrazole derivatives have been investigated using the density function-based range separated hybrid GGA functional <i>ω</i>B97XD with 6-311G(d) basis. Both intrinsic reaction coordinate (IRC) and distinguished co-ordinate (variation of O–H distance of the enol tautomer) have been chosen as a proton transfer co-ordinate of the titled compounds for comparison. Our study reveals that the various electrical responsive parameters like average polarizability (<i>α</i><sub>av</sub>), first hyperpolarizability (<i>β</i><sub>av</sub>) and global reactivity descriptors e.g., chemical hardness (<i>η</i>), electrophilicity index (<i>ω</i>) along the proton transfer co-ordinate are in conformity with the respective optimum principles. Maximum value of <i>β</i><sub>av</sub> is found in the case of nitro substituted pyrazole derivative. Variation of <i>β</i><sub>av</sub> along the proton transfer co-ordinate for all compounds have been correlated with the variation of Δ<i>µf</i><sub>0</sub>/(<i>S</i><sub>1</sub>-<i>S</i><sub>0</sub>)<sup>3</sup> using two-level approximation and electronic special extent (&lt;<i>R</i><sup>2</sup>&gt;) along the proton transfer coordinate.
DOI: 10.6084/m9.figshare.12859744
title: Some <i>ab initio</i> thoughts on the bonding in O<sub>3</sub>H

description: We study the ground X~2A′′ state of O<sub>3</sub>H (= O<sub>a</sub>O<sub>b</sub>O<sub>c</sub>H) with single (RCCSD(T)) and multi (MRCI) reference correlation methods in order to shed some light on its bonding mechanism in connection with its low dissociation energy and rather long bond distance (O<sub>a</sub>O<sub>b</sub>−O<sub>c</sub>H). For such a task all three dissociation/formation paths were considered (O<sub>2 </sub>+ OH, O + O<sub>2</sub>H, and O<sub>3 </sub>+ H) and the associated nonadiabatic coupling matrix elements were examined. It appears that the excited states of the above asymptotic fragments participate in the equilibrium wavefunction of O<sub>3</sub>H in a way that results in a symmetry broken structure.
DOI: 10.6084/m9.figshare.12859744.v1
title: Some <i>ab initio</i> thoughts on the bonding in O<sub>3</sub>H

description: We study the ground X~2A′′ state of O<sub>3</sub>H (= O<sub>a</sub>O<sub>b</sub>O<sub>c</sub>H) with single (RCCSD(T)) and multi (MRCI) reference correlation methods in order to shed some light on its bonding mechanism in connection with its low dissociation energy and rather long bond distance (O<sub>a</sub>O<sub>b</sub>−O<sub>c</sub>H). For such a task all three dissociation/formation paths were considered (O<sub>2 </sub>+ OH, O + O<sub>2</sub>H, and O<sub>3 </sub>+ H) and the associated nonadiabatic coupling matrix elements were examined. It appears that the excited states of the above asymptotic fragments participate in the equilibrium wavefunction of O<sub>3</sub>H in a way that results in a symmetry broken structure.
DOI: 10.48483/lg/lnzr03
title: Jan 2021 Big Push Data

description: This data was used to award CHVs base on Big push Criteria
DOI: 10.25625/81mimi/odlwrp
title: code_dynamic_microtubule_analyze_growth_rate_and_catastrophe_frequency.m

description: analysis code for growth rate and catastrophe frequency of microtubules
DOI: 10.25625/81mimi
title: analysis code used to determine the growth rate and the catastrophe frequency of microtubules

description: analysis code used to determine the growth rate and the catastrophe frequency of microtubules
DOI: 10.25625/2hxsfj/5y94h6
title: code_dynamic_microtubule.py

description: simulation code used to model the dynamic microtubules
DOI: 10.25625/2hxsfj
title: simulation code for dynamic microtubules

description: simulation code used to model dynamic microtubules
DOI: 10.17870/bathspa.12287861.v1
title: A film about a city - 300-word Statement

description: <i>A film about a city</i> consists of a number of architecture models placed on tables, each recreating a partial narrative of an imaginary city, part autobiographical, part fictional, that reflected idiosyncrasies of city life and public space.<br><br>This item contains a 300-word statement about the project.
DOI: 10.17870/bathspa.12287861
title: A film about a city - 300-word Statement

description: <i>A film about a city</i> consists of a number of architecture models placed on tables, each recreating a partial narrative of an imaginary city, part autobiographical, part fictional, that reflected idiosyncrasies of city life and public space.<br><br>This item contains a 300-word statement about the project.
DOI: 10.17870/bathspa.12287864
title: A film about a city - Research Timeline and Research Questions

description: <i>A film about a city</i> consists of a number of architecture models placed on tables, each recreating a partial narrative of an imaginary city, part autobiographical, part fictional, that reflected idiosyncrasies of city life and public space.<br><br>This item contains a Research Timeline and Research Questions for the project.
DOI: 10.17870/bathspa.12287864.v1
title: A film about a city - Research Timeline and Research Questions

description: <i>A film about a city</i> consists of a number of architecture models placed on tables, each recreating a partial narrative of an imaginary city, part autobiographical, part fictional, that reflected idiosyncrasies of city life and public space.<br><br>This item contains a Research Timeline and Research Questions for the project.
DOI: 10.17870/bathspa.12264209
title: A film about a city - Exhibition Photophraphy

description: <i>A film about a city</i> consists of a number of architecture models placed on tables, each recreating a partial narrative of an imaginary city, part autobiographical, part fictional, that reflected idiosyncrasies of city life and public space.<br>This item contains images of the architecture models that make up<i> A film about a city</i>. The images were taken while <i>A film about a city</i> was being exhibited at Gallery Vera Cortes, Lisbon, Portugal in 2017.<br><br>Photographs by John Wood and Paul Harrison; used with permission.<br><br><b>This work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law.</b>
DOI: 10.17870/bathspa.12465524
title: A film about a city - Exhibitions

description: <i>A film about a city</i> consists of a number of architecture models placed on tables, each recreating a partial narrative of an imaginary city, part autobiographical, part fictional, that reflected idiosyncrasies of city life and public space.<br><br>This item contains information about exhibitions in which<i> A film about a city </i>was shown. These exhibitions were:<br><br><i>An almost identical copy</i> at Carroll/Fletcher, London, UK 24th April-30th May, 2015<br><br><i>Some Things are Undesigned</i> at von Bartha, Basel, Switzerland 7th November 2015 - 23rd January 2016<br><br><i>Other Plans</i> Gallery Vera Cortes, Lisbon, Portugal, 27th January - 11th March 2017<br>Used with permission.<br><b>The work is under copyright and may not be used without permission. Use of this repository acknowledges cooperation with its policies and relevant copyright law. </b><br>
DOI: 10.25625/72rp7e/yfhoqp
title: code_simulate_single_interactions.m

description: simulation code for filament-filament interactions
DOI: 10.25625/72rp7e
title: simulation code for filament-filament interactions

description: simulation code used to model the interactions between vimentin intermediate filaments and microtubules
DOI: 10.48483/lg/xfqxjf
title: Pregnancies Data Jan 2017- Jan 2021

description: This is the aggregate data of all the women of reproductive age who have ever gotten pregnant from Jan 2018 to date from all the 13 branches of LG's direct operations.
DOI: 10.25625/tjv3f8/vbkgzu
title: Source_Data_File_Supplementary_Information.xlsx

description: data used for the figures in the Supplementary Information
DOI: 10.25625/tjv3f8
title: Source Data File (Supplementary Information)

description: source data which support the results presented in the corresponding publication, Supplementary Information, as an Excel spreadsheet, one page per figure
DOI: 10.6084/m9.figshare.14260091
title: Xiao et al. The data of AoBP paper "Divergence of stem biomechanics and hydraulics between Bauhinia lianas and trees"

description: Liana abundance and biomass are increasing in neotropical and Asian tropical seasonal forests over the past decades. Stem mechanical properties and hydraulic traits influence the growth and survival of plants, yet the differences in stem mechanical and hydraulic performance between congeneric lianas and trees remain poorly understood. Here, we measured 11 stem mechanical and hydraulic traits for 10 liana species and 10 tree species from Bauhinia grown in a tropical common garden. Our results showed that Bauhinia lianas possessed lower stem mechanical strength as indicated by both modulus of elasticity and modulus of rupture, and higher stem potential hydraulic conductivity than congeneric trees. Such divergence was mainly attributed to the differentiation in liana and tree life forms. Whether the phylogenetic effect was considered or not, mechanical strength was positively correlated with wood density, vessel conduit wall reinforcement and sapwood content across species. Results of principle component analysis showed that traits related to mechanical safety and hydraulic efficiency were loaded in the opposite direction, suggesting a trade-off between biomechanics and hydraulics. Our results provide evidence for obvious differentiation in mechanical demand and hydraulic efficiency between congeneric lianas and trees.