cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.60645/bdc-d340-52s3
title: Heart Failure Network Oral Iron Repletion Effects on Oxygen Uptake in Heart Failure (HFN IRONOUT-BioLINCC)

description: 
<u>Objectives</u><br>To test the hypothesis that, compared to placebo, oral iron repletion in heart failure patients with iron deficiency improves exercise capacity after 16 weeks of therapy.

<u>Background </u><br>Iron deficiency affects approximately one half of patients with symptomatic heart failure. The presence of iron deficiency in patients with heart failure is associated with reduced functional capacity, poorer quality of life, and increased mortality. 

Despite growing recognition of the significance of iron deficiency, randomized multicenter trials exploring the utility of oral iron supplementation, a therapy that is inexpensive, readily available, and safe, have not been performed in patients with heart failure. Moreover, patient characteristics and biochemical profiles that may influence responsiveness to oral iron in patients with heart failure have not been defined. Results of intravenous iron repletion trials have been favorable, but regularly treating patients with intravenous iron products is expensive and poses logistical challenges for outpatients. Therefore, the HFN-IRONOUT study was initiated to investigate the efficacy of oral iron in patients with heart failure with reduced ejection fraction (HFrEF). 

<u>Participants</u><br>A total of 225 participants were enrolled, 111 randomized to receive oral iron and 114 randomized to receive the placebo. 

<u>Design </u><br>The HFN-IRONOUT study was a phase 2, double-blind, placebo-controlled randomized clinical trial that enrolled participants at 23 sites in the United States. Participants were randomly assigned, in a 1:1 ratio, to receive either oral iron polysaccharide or placebo with the use of an automated web-based system. A permuted block randomization method (with 4 participants per block) was stratified by enrolling site and anemia status (defined as hemoglobin < 12 g/dL). Study drug was administered orally at 150 mg, twice daily for 16 weeks. 

At baseline, 8 weeks, and 16 weeks participants underwent studies including history and physical examination, cardiopulmonary exercise testing (CPET), Kansas City Cardiomyopathy Questionnaire (KCCQ), and 6-minute walk test. CPETs were performed using a 10 Watt/minute incremental ramp protocol and breath-by-breath measures of oxygen uptake were uniformly analyzed by the CPET Core Lab. Participants also underwent phlebotomy for biomarkers. Iron studies, including iron, total iron binding capacity, and ferritin, were measured at baseline and after 16 weeks to determine the extent to which oral iron led to iron repletion. 

The primary end point was the change in peak oxygen uptake (peak VO2) after 16 weeks of therapy. 

<u>Conclusions </u><br>Among participants with HFrEF with iron deficiency, high-dose oral iron did not improve exercise capacity over 16 weeks.
DOI: 10.60645/bdc-h080-koj3
title: Framingham Heart Study-Cohort (FHS-Cohort) - Imaging

description: 
The Framingham Heart Study (FHS) is a population-based, observational cohort study initiated in 1948 to prospectively investigate the determinants of cardiovascular disease to guide public health prevention. The FHS began by recruiting an Original Cohort of 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, who had not yet developed overt symptoms of cardiovascular disease or suffered a heart attack or stroke. The Original cohort Exam 1 took place between 1948 and 1953. Since that time the cohort has had a total of 32 biennial exams (ending in 2014) and event follow-up through 2022. 

In 1971, the FHS added the Offspring cohort, comprising 5124 children whose parents were enrolled in the Original cohort and the spouses of the children. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. The latest exam (10) was completed in 2022. 

In 2002, the transgenerational FHS design was facilitated with the recruitment of 4095 children of the Offspring cohort (Third Generation), and 103 spouses of the Offspring who were not previously enrolled in the study (New Offspring Spouses, NOS). These cohorts have completed 3 exams through 2019. 

To reflect the changing demographic characteristics of the greater Framingham community, the FHS additionally recruited and enrolled 2 cohorts comprising racial and ethnic minority groups, termed Omni-1 and Omni-2, (n = 506 and 410, respectively) in 1995 and 2002, respectively. These cohorts included individuals of African American, Hispanic, Asian, Indian, Native American, and Pacific Islander descent. The OMNI-1 cohort have completed 5 exams through 2022. The OMNI-2 cohort have completed 3 exams through 2019. 

Data available for request include Echocardiogram images, available from the following exams in each cohort. 

Original Cohort: exams 18-32; 

Offspring cohort: exams 3-10; 

Third Generation, NOS and OMNI-2 cohorts: exams 1-3; 

OMNI-1 cohort: exams 1-5. 

Summary level phenotypes for the Framingham Cohort study participants can be viewed at the top-level study page [phs000007](./study.cgi?study_id=phs000007) Framingham Cohort. Individual level phenotype data and molecular data for all Framingham top-level study and substudies are available by requesting Authorized Access to the Framingham Cohort study [phs000007](./study.cgi?study_id=phs000007).
DOI: 10.60645/bdc-356p-pt1k
title: Framingham Heart Study-Cohort (FHS-Cohort) - Imaging

description: 
The Framingham Heart Study (FHS) is a population-based, observational cohort study initiated in 1948 to prospectively investigate the determinants of cardiovascular disease to guide public health prevention. The FHS began by recruiting an Original Cohort of 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, who had not yet developed overt symptoms of cardiovascular disease or suffered a heart attack or stroke. The Original cohort Exam 1 took place between 1948 and 1953. Since that time the cohort has had a total of 32 biennial exams (ending in 2014) and event follow-up through 2022. 

In 1971, the FHS added the Offspring cohort, comprising 5124 children whose parents were enrolled in the Original cohort and the spouses of the children. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. The latest exam (10) was completed in 2022. 

In 2002, the transgenerational FHS design was facilitated with the recruitment of 4095 children of the Offspring cohort (Third Generation), and 103 spouses of the Offspring who were not previously enrolled in the study (New Offspring Spouses, NOS). These cohorts have completed 3 exams through 2019. 

To reflect the changing demographic characteristics of the greater Framingham community, the FHS additionally recruited and enrolled 2 cohorts comprising racial and ethnic minority groups, termed Omni-1 and Omni-2, (n = 506 and 410, respectively) in 1995 and 2002, respectively. These cohorts included individuals of African American, Hispanic, Asian, Indian, Native American, and Pacific Islander descent. The OMNI-1 cohort have completed 5 exams through 2022. The OMNI-2 cohort have completed 3 exams through 2019. 

Data available for request include Echocardiogram images, available from the following exams in each cohort. 

Original Cohort: exams 18-32; 

Offspring cohort: exams 3-10; 

Third Generation, NOS and OMNI-2 cohorts: exams 1-3; 

OMNI-1 cohort: exams 1-5. 

Summary level phenotypes for the Framingham Cohort study participants can be viewed at the top-level study page [phs000007](./study.cgi?study_id=phs000007) Framingham Cohort. Individual level phenotype data and molecular data for all Framingham top-level study and substudies are available by requesting Authorized Access to the Framingham Cohort study [phs000007](./study.cgi?study_id=phs000007).
DOI: 10.60645/bdc-s0o1-jk48
title: Framingham Heart Study-Cohort (FHS-Cohort) - Imaging

description: 
The Framingham Heart Study (FHS) is a population-based, observational cohort study initiated in 1948 to prospectively investigate the determinants of cardiovascular disease to guide public health prevention. The FHS began by recruiting an Original Cohort of 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, who had not yet developed overt symptoms of cardiovascular disease or suffered a heart attack or stroke. The Original cohort Exam 1 took place between 1948 and 1953. Since that time the cohort has had a total of 32 biennial exams (ending in 2014) and event follow-up through 2022. 

In 1971, the FHS added the Offspring cohort, comprising 5124 children whose parents were enrolled in the Original cohort and the spouses of the children. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. The latest exam (10) was completed in 2022. 

In 2002, the transgenerational FHS design was facilitated with the recruitment of 4095 children of the Offspring cohort (Third Generation), and 103 spouses of the Offspring who were not previously enrolled in the study (New Offspring Spouses, NOS). These cohorts have completed 3 exams through 2019. 

To reflect the changing demographic characteristics of the greater Framingham community, the FHS additionally recruited and enrolled 2 cohorts comprising racial and ethnic minority groups, termed Omni-1 and Omni-2, (n = 506 and 410, respectively) in 1995 and 2002, respectively. These cohorts included individuals of African American, Hispanic, Asian, Indian, Native American, and Pacific Islander descent. The OMNI-1 cohort have completed 5 exams through 2022. The OMNI-2 cohort have completed 3 exams through 2019. 

Data available for request include Echocardiogram images, available from the following exams in each cohort. 

Original Cohort: exams 18-32; 

Offspring cohort: exams 3-10; 

Third Generation, NOS and OMNI-2 cohorts: exams 1-3; 

OMNI-1 cohort: exams 1-5. 

Summary level phenotypes for the Framingham Cohort study participants can be viewed at the top-level study page [phs000007](./study.cgi?study_id=phs000007) Framingham Cohort. Individual level phenotype data and molecular data for all Framingham top-level study and substudies are available by requesting Authorized Access to the Framingham Cohort study [phs000007](./study.cgi?study_id=phs000007).
DOI: 10.60645/bdc-497y-xx6c
title: Framingham Heart Study-Cohort (FHS-Cohort) - Imaging

description: 
The Framingham Heart Study (FHS) is a population-based, observational cohort study initiated in 1948 to prospectively investigate the determinants of cardiovascular disease to guide public health prevention. The FHS began by recruiting an Original Cohort of 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, who had not yet developed overt symptoms of cardiovascular disease or suffered a heart attack or stroke. The Original cohort Exam 1 took place between 1948 and 1953. Since that time the cohort has had a total of 32 biennial exams (ending in 2014) and event follow-up through 2022. 

In 1971, the FHS added the Offspring cohort, comprising 5124 children whose parents were enrolled in the Original cohort and the spouses of the children. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. The latest exam (10) was completed in 2022. 

In 2002, the transgenerational FHS design was facilitated with the recruitment of 4095 children of the Offspring cohort (Third Generation), and 103 spouses of the Offspring who were not previously enrolled in the study (New Offspring Spouses, NOS). These cohorts have completed 3 exams through 2019. 

To reflect the changing demographic characteristics of the greater Framingham community, the FHS additionally recruited and enrolled 2 cohorts comprising racial and ethnic minority groups, termed Omni-1 and Omni-2, (n = 506 and 410, respectively) in 1995 and 2002, respectively. These cohorts included individuals of African American, Hispanic, Asian, Indian, Native American, and Pacific Islander descent. The OMNI-1 cohort have completed 5 exams through 2022. The OMNI-2 cohort have completed 3 exams through 2019. 

Data available for request include Echocardiogram images, available from the following exams in each cohort. 

Original Cohort: exams 18-32; 

Offspring cohort: exams 3-10; 

Third Generation, NOS and OMNI-2 cohorts: exams 1-3; 

OMNI-1 cohort: exams 1-5. 

Summary level phenotypes for the Framingham Cohort study participants can be viewed at the top-level study page [phs000007](./study.cgi?study_id=phs000007) Framingham Cohort. Individual level phenotype data and molecular data for all Framingham top-level study and substudies are available by requesting Authorized Access to the Framingham Cohort study [phs000007](./study.cgi?study_id=phs000007).
DOI: 10.15468/dl.wavqkd
title: Occurrence Download

description: A dataset listing the 159 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Inventaires Aéro Biodiversité - LFGI - Dijon Darois-Inventaires Aéro Biodiversité - LFGI - Observation opportuniste plateforme"
 ]
}

 The dataset's 159 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016308-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.15476048
title: Data on climate targets

description: Data on Climate Targets 

This dataset contains detailed, machine-readable data on climate (emissions-reduction) targets for the EU-27 for the years 1997-2026.

This dataset was developed by Aksornchan Chaianong and Puru Malhotra, from 2024 to January 2026. Aksornchan Chaianong led the work, with support from Ioannis Milioritsas, Silvia Weko, and Johan Lilliestam.

The data is published with CC BY-SA 4.0. Please cite it as:

Chaianong, A., Malhotra P., Milioritsas, I., Weko, S., and Lilliestam, J. (2026): Data on climate targets (Version 2, January 2026). Sustainability Transition Policy Group, Friedrich-Alexander-Universität Erlangen-Nürnberg. DOI: 10.5281/zenodo.18482359

The authors would like to thank the German Federal Government, the German State Governments, and the Joint Science Conference (GWK) for their funding and support as part of the NFDI4Energy consortium. The work was funded by the German Research Foundation (DFG) – 501865131 within the German National Research Data Infrastructure (NFDI, www.nfdi.de). Aksornchan Chaianong would also like to thank the Office for Equal Opportunities for Women in Science and the Arts at the School of Business, Economics, and Law at FAU Erlangen-Nürnberg for the Individual Career Development funding.

The data are, to the best of our knowledge, correct, but we assume no responsibility for any remaining data errors or publication errors. Should you find errors or have data to fill gaps, please contact climatepolicyatlas@nfdi4energy.org.

Note: the previous version of the dataset is V1, and is no longer up to date.
DOI: 10.5281/zenodo.18482359
title: Data on climate targets

description: Data on Climate Targets 

This dataset contains detailed, machine-readable data on climate (emissions-reduction) targets for the EU-27 for the years 1997-2026.

This dataset was developed by Aksornchan Chaianong and Puru Malhotra, from 2024 to January 2026. Aksornchan Chaianong led the work, with support from Ioannis Milioritsas, Silvia Weko, and Johan Lilliestam.

The data is published with CC BY-SA 4.0. Please cite it as:

Chaianong, A., Malhotra P., Milioritsas, I., Weko, S., and Lilliestam, J. (2026): Data on climate targets (Version 2, January 2026). Sustainability Transition Policy Group, Friedrich-Alexander-Universität Erlangen-Nürnberg. DOI: 10.5281/zenodo.18482359

The authors would like to thank the German Federal Government, the German State Governments, and the Joint Science Conference (GWK) for their funding and support as part of the NFDI4Energy consortium. The work was funded by the German Research Foundation (DFG) – 501865131 within the German National Research Data Infrastructure (NFDI, www.nfdi.de). Aksornchan Chaianong would also like to thank the Office for Equal Opportunities for Women in Science and the Arts at the School of Business, Economics, and Law at FAU Erlangen-Nürnberg for the Individual Career Development funding.

The data are, to the best of our knowledge, correct, but we assume no responsibility for any remaining data errors or publication errors. Should you find errors or have data to fill gaps, please contact climatepolicyatlas@nfdi4energy.org.

Note: the previous version of the dataset is V1, and is no longer up to date.
DOI: 10.15468/dl.wt3pme
title: Occurrence Download

description: A dataset listing the 149 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Inventaires Aéro Biodiversité - LFGI - Dijon Darois-Inventaires Aéro Biodiversité - LFGI - Observation opportuniste extérieur plateforme"
 ]
}

 The dataset's 149 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016310-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60645/bdc-2dqi-g421
title: Cardiovascular Health Study (CHS) - Imaging

description: 
The [Cardiovascular Health Study](https://www.nhlbi.nih.gov/science/cardiovascular-health-study-chs) (CHS) is a prospective study of risk factors for development and progression of coronary heart disease (CHD) and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 

Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 

Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication, and mortality.
DOI: 10.60645/bdc-3d5k-7365
title: Cardiovascular Health Study (CHS) - Imaging

description: 
The [Cardiovascular Health Study](https://www.nhlbi.nih.gov/science/cardiovascular-health-study-chs) (CHS) is a prospective study of risk factors for development and progression of coronary heart disease (CHD) and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 

Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 

Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication, and mortality.
DOI: 10.15468/dl.ee3ubk
title: Occurrence Download

description: A dataset containing 46 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Raphia farinifera",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 46 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0016315-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60645/bdc-4l4z-22fu
title: Cardiovascular Health Study (CHS) - Imaging

description: 
The [Cardiovascular Health Study](https://www.nhlbi.nih.gov/science/cardiovascular-health-study-chs) (CHS) is a prospective study of risk factors for development and progression of coronary heart disease (CHD) and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93. 

Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health. 

Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication, and mortality.