cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17633/rd.brunel.23284226.v1
title: Impact of lower limb heating and exercise on leg blood flow in trained elderly and young humans

description: <em>The present study investigated the temperature, haemodynamic and tissue oxygenation responses to 90 min single-leg heating, single-leg dynamic knee-extensor exercise with heating, and control-leg (normothermic conditions) single-leg dynamic knee-extensor exercise in elderly and young participants. Dynamic knee-extensor exercise was performed at two workloads, 6W and 12W, continuously for 10 min (5 min for each workload). </em>
<br>
<em><strong>Sheet 1</strong></em> <em>outlines the data structure, abbreviations used and provides a useful schematic of the study protocol. </em>
<br>
<em><strong>Sheet 2</strong></em> <em>reports participant characteristics such as age, mass, height, sex, leg lean/non-lean volumes.</em>
<br>
<em><strong>Sheet 3</strong></em> <em>illustrates the core and skin temperature, central haemodynamic and tissue oxygenation responses during 90 min passive single-leg heating, single-leg heating and dynamic knee-extensor exercise, and control leg knee-extensor exercise.</em>
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<em><strong>Sheet 4</strong></em> <em>reports the leg haeomdynamic responses (blood velocity, arterial diameter, blood flow, shear rate and vascular conductance) in the common, superficial, profunda femoral arteries and popliteal artery during 90 min passive single-leg heating, single-leg heating and dynamic knee-extensor exercise, and control leg knee-extensor exercise.</em>
DOI: 10.5519/qd.esoe71iv
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (90 records)
DOI: 10.17633/rd.brunel.25061837
title: Temperature and blood flow coupling during thigh heating interventions

description: A positive relationship between local tissue temperature and perfusion exists, with isolated limb-segment hyperthermia stimulating hyperaemia in the heated region without affecting the adjacent, non-heated limb segment. However, whether partial-limb segment heating evokes a heightened tissue perfusion in the heated region without directly or reflexly affecting the non-heated tissues of the same limb segment remains unknown. This study investigated, in eleven healthy young adults, the lower limb temperature and haemodynamic responses to three levels of 1 h upper-leg heating, none of which alter core temperature: (1) whole-thigh (WTH; water-perfused garment), (2) quadriceps (QH; water-perfused garment), and (3) partial-quadriceps (PQH; pulsed shortwave diathermy) heating. It was hypothesised that perfusion will only increase in the heated regions. WTH, QH and PQH increased local heated tissue temperature by 2.9 ± 0.6, 2.0 ± 0.7 and 2.9 ± 1.3 ºC (p &lt; 0.0001), respectively, whilst remaining unchanged in the non-heated hamstrings and quadriceps tissues during QH and PQH. WTH induced a 2-fold increase in common femoral artery blood flow (p &lt; 0.0001) whereas QH and PQH evoked a similar ~1.4-fold elevation (p ≤ 0.0018). During QH and PQH, however, tissue oxygen saturation and laser-Doppler skin blood flow in the adjacent non-heated hamstrings or quadriceps tissues remained stable (p &gt; 0.5000). These findings in healthy young humans demonstrate a tight thermo-haemodynamic coupling during regional thigh heating, providing further evidence of the importance of local heat-activated mechanisms on the control of blood circulation.
DOI: 10.17633/rd.brunel.25061837.v1
title: Temperature and blood flow coupling during thigh heating interventions

description: A positive relationship between local tissue temperature and perfusion exists, with isolated limb-segment hyperthermia stimulating hyperaemia in the heated region without affecting the adjacent, non-heated limb segment. However, whether partial-limb segment heating evokes a heightened tissue perfusion in the heated region without directly or reflexly affecting the non-heated tissues of the same limb segment remains unknown. This study investigated, in eleven healthy young adults, the lower limb temperature and haemodynamic responses to three levels of 1 h upper-leg heating, none of which alter core temperature: (1) whole-thigh (WTH; water-perfused garment), (2) quadriceps (QH; water-perfused garment), and (3) partial-quadriceps (PQH; pulsed shortwave diathermy) heating. It was hypothesised that perfusion will only increase in the heated regions. WTH, QH and PQH increased local heated tissue temperature by 2.9 ± 0.6, 2.0 ± 0.7 and 2.9 ± 1.3 ºC (p &lt; 0.0001), respectively, whilst remaining unchanged in the non-heated hamstrings and quadriceps tissues during QH and PQH. WTH induced a 2-fold increase in common femoral artery blood flow (p &lt; 0.0001) whereas QH and PQH evoked a similar ~1.4-fold elevation (p ≤ 0.0018). During QH and PQH, however, tissue oxygen saturation and laser-Doppler skin blood flow in the adjacent non-heated hamstrings or quadriceps tissues remained stable (p &gt; 0.5000). These findings in healthy young humans demonstrate a tight thermo-haemodynamic coupling during regional thigh heating, providing further evidence of the importance of local heat-activated mechanisms on the control of blood circulation.
DOI: 10.6084/m9.figshare.25060199
title: Supplementary Material for: Neuropsychological Assessments of Cognitive Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis with Meta-Regression

description: <b><i>Introduction:</i></b> Cognitive dysfunction or deficits are common in patients with major depressive disorder (MDD). The current study systematically reviews and meta-analyzes multiple domains of cognitive impairment in patients with MDD. <b><i>Methods:</i></b> PubMed/MEDLINE, PsycINFO, Cochrane Library, Embase, Web of Science, and Google Scholar were searched from inception through May 17, 2023, with no language limits. Studies with the following inclusion criteria were included: (1) patients with a diagnosis of MDD using standardized diagnostic criteria; (2) healthy controls (i.e., those without MDD); (3) neuropsychological assessments of cognitive impairment using Cambridge Neuropsychological Test Automated Battery (CANTAB); and (4) reports of sufficient data to quantify standardized effect sizes. Hedges’ <i>g</i> standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were used to quantify effect sizes of cognitive impairments in MDD. SMDs were estimated using a fixed- or random-effects models. <b><i>Results:</i></b> Overall, 33 studies consisting of 2,596 subjects (<i>n</i> = 1,337 for patients with MDD and <i>n</i> = 1,259 for healthy controls) were included. Patients with MDD, when compared to healthy controls, had moderate cognitive deficits (SMD, −0.39 [95% CI, −0.47 to −0.31]). In our subgroup analyses, patients with treatment-resistant depression (SMD, −0.56 [95% CI, −0.78 to −0.34]) and older adults with MDD (SMD, −0.51 [95% CI, −0.66 to −0.36]) had greater cognitive deficits than healthy controls. The effect size was small among unmedicated patients with MDD (SMD, −0.19 [95% CI, −0.37 to −0.00]), and we did not find any statistical difference among children. Cognitive deficits were consistently found in all domains, except the reaction time. No publication bias was reported. <b><i>Conclusion:</i></b> Because cognitive impairment in MDD can persist in remission or increase the risk of major neurodegenerative disorders, remediation of cognitive impairment in addition to alleviation of depressive symptoms should be an important goal when treating patients with MDD.
DOI: 10.6084/m9.figshare.25060199.v1
title: Supplementary Material for: Neuropsychological Assessments of Cognitive Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis with Meta-Regression

description: <b><i>Introduction:</i></b> Cognitive dysfunction or deficits are common in patients with major depressive disorder (MDD). The current study systematically reviews and meta-analyzes multiple domains of cognitive impairment in patients with MDD. <b><i>Methods:</i></b> PubMed/MEDLINE, PsycINFO, Cochrane Library, Embase, Web of Science, and Google Scholar were searched from inception through May 17, 2023, with no language limits. Studies with the following inclusion criteria were included: (1) patients with a diagnosis of MDD using standardized diagnostic criteria; (2) healthy controls (i.e., those without MDD); (3) neuropsychological assessments of cognitive impairment using Cambridge Neuropsychological Test Automated Battery (CANTAB); and (4) reports of sufficient data to quantify standardized effect sizes. Hedges’ <i>g</i> standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were used to quantify effect sizes of cognitive impairments in MDD. SMDs were estimated using a fixed- or random-effects models. <b><i>Results:</i></b> Overall, 33 studies consisting of 2,596 subjects (<i>n</i> = 1,337 for patients with MDD and <i>n</i> = 1,259 for healthy controls) were included. Patients with MDD, when compared to healthy controls, had moderate cognitive deficits (SMD, −0.39 [95% CI, −0.47 to −0.31]). In our subgroup analyses, patients with treatment-resistant depression (SMD, −0.56 [95% CI, −0.78 to −0.34]) and older adults with MDD (SMD, −0.51 [95% CI, −0.66 to −0.36]) had greater cognitive deficits than healthy controls. The effect size was small among unmedicated patients with MDD (SMD, −0.19 [95% CI, −0.37 to −0.00]), and we did not find any statistical difference among children. Cognitive deficits were consistently found in all domains, except the reaction time. No publication bias was reported. <b><i>Conclusion:</i></b> Because cognitive impairment in MDD can persist in remission or increase the risk of major neurodegenerative disorders, remediation of cognitive impairment in addition to alleviation of depressive symptoms should be an important goal when treating patients with MDD.
DOI: 10.6084/m9.figshare.24971802
title: Supplementary Material for: Clinical and Molecular Characterization of Mucopolysaccharidosis Type 3A and 3B in a Turkish Series

description: Introduction: Sanfilippo syndrome or mucopolysaccharidosis type 3 (MPS-3) is a rare condition and its epidemiological data are still not defined. MPS-3 is linked to a deficiency in enzymes involved in heparan sulfate degradation. This biomolecule is neurotoxic and its accumulation underlies the severe central nervous system degeneration observed in this disease.
Methods: Here, we describe 15 Turkish patients with MPS-3A or MPS-3B subtypes. Clinical data upon the diagnosis and during the follow-up as well as molecular characterization are reported. 
Results: Two and ten distinct variants were identified in SGSH and NAGLU gene sequences, respectively. Six variants (NAGLU NM_000263.3:c.532-?_c.764+?del, NAGLU NM_000263.3: c.509G&gt;T, NAGLU NM_000263.3: c.700C&gt;G, NAGLU NM_000263.3:c.507_516 del, NAGLU NM dises_000263.3: c.1354 G&gt;A, NAGLU NM_000263.3: c.200T&gt;C) have been previously published and 6 are novel (SGSH NM_000199.4: c.80T&gt;G, SGSH NM_000199.4: c.7_16del, NAGLU NM_000263.3: c.224_235del, NAGLU NM_000263.3: c.904G&gt;T, NAGLU NM_000263.3: c.626C&gt;T, NAGLU NM_000263.3: c.1241A&gt;G). SGSH NM_000199.4:c.7_16del variation might be caused by a founder effect.
Conclusion: Due to the high rate of consanguinity in Turkey, the incidence of Sanfilippo Syndrome might be higher compared to other populations worldwide. Our results contribute to the characterization of rare diseases in Turkey and to improve our knowledge of the clinical, molecular and epidemiological aspects of MPS-3 disease.
DOI: 10.6084/m9.figshare.24971802.v1
title: Supplementary Material for: Clinical and Molecular Characterization of Mucopolysaccharidosis Type 3A and 3B in a Turkish Series

description: Introduction: Sanfilippo syndrome or mucopolysaccharidosis type 3 (MPS-3) is a rare condition and its epidemiological data are still not defined. MPS-3 is linked to a deficiency in enzymes involved in heparan sulfate degradation. This biomolecule is neurotoxic and its accumulation underlies the severe central nervous system degeneration observed in this disease.
Methods: Here, we describe 15 Turkish patients with MPS-3A or MPS-3B subtypes. Clinical data upon the diagnosis and during the follow-up as well as molecular characterization are reported. 
Results: Two and ten distinct variants were identified in SGSH and NAGLU gene sequences, respectively. Six variants (NAGLU NM_000263.3:c.532-?_c.764+?del, NAGLU NM_000263.3: c.509G&gt;T, NAGLU NM_000263.3: c.700C&gt;G, NAGLU NM_000263.3:c.507_516 del, NAGLU NM dises_000263.3: c.1354 G&gt;A, NAGLU NM_000263.3: c.200T&gt;C) have been previously published and 6 are novel (SGSH NM_000199.4: c.80T&gt;G, SGSH NM_000199.4: c.7_16del, NAGLU NM_000263.3: c.224_235del, NAGLU NM_000263.3: c.904G&gt;T, NAGLU NM_000263.3: c.626C&gt;T, NAGLU NM_000263.3: c.1241A&gt;G). SGSH NM_000199.4:c.7_16del variation might be caused by a founder effect.
Conclusion: Due to the high rate of consanguinity in Turkey, the incidence of Sanfilippo Syndrome might be higher compared to other populations worldwide. Our results contribute to the characterization of rare diseases in Turkey and to improve our knowledge of the clinical, molecular and epidemiological aspects of MPS-3 disease.
DOI: 10.5281/zenodo.10552513
title: Experimental process data from throughput tests

description: Excel spreadsheets containing numeric values from throughput tests with textual description.

Each file refers to one specific combination of screw and polymer grade.

The following process variables were recorded:



screw speed

barrel temperatures

mass throughput

torque

melt pressure at seven axial positions

melt temperature distribution at the screw tip
DOI: 10.7916/25tp-0k34
title:  Children’s Moral Evaluations of and Behaviors toward People Who are Curious about Religion and Science (Data)
DOI: 10.6084/m9.figshare.25062209
title: Data - CL DIPJ

description: Data base for submission
DOI: 10.5281/zenodo.8380173
title: Single-atom catalysis in space: Computational exploration of Fischer–Tropsch reactions in astrophysical environments

description: This supporting material contains:



	
Cartesian coordinates of the PBE optimized minima and transition states for the reactions under study, in XYZ format.
	
Inputs for the CP2K and Crystal17 packages.
	
Vibrational calculations with all the frequencies.
	
Inputs and outputs for the benchmark study performed with the Gaussian16 package.
DOI: 10.5281/zenodo.8380174
title: Single-atom catalysis in space: Computational exploration of Fischer–Tropsch reactions in astrophysical environments

description: This supporting material contains:



	
Cartesian coordinates of the PBE optimized minima and transition states for the reactions under study, in XYZ format.
	
Inputs for the CP2K and Crystal17 packages.
	
Vibrational calculations with all the frequencies.
	
Inputs and outputs for the benchmark study performed with the Gaussian16 package.
DOI: 10.5281/zenodo.10554600
title: Performance simulation of long term low GWP alternative refrigerants for the prototype of a low environmental impact HP

description: This dataset is generated by CNR-ITC in order to simulate and compare the thermodynamic performance of long-term low GWP alternative refrigerants in Heat Pump cycles at various operating conditions. The purpose of this dataset within the project is to select the most promising fluid for a low environmental impact HP developed by HIREF. The generated data are thermodynamic properties and performance, such as COP (Coefficient of Performance) and VHE (Volumetric Heating Efficiency) values, from simulation of thermodynamic HP cycles with homemade software developed in Matlab environment.
DOI: 10.5281/zenodo.10554601
title: Performance simulation of long term low GWP alternative refrigerants for the prototype of a low environmental impact HP

description: This dataset is generated by CNR-ITC in order to simulate and compare the thermodynamic performance of long-term low GWP alternative refrigerants in Heat Pump cycles at various operating conditions. The purpose of this dataset within the project is to select the most promising fluid for a low environmental impact HP developed by HIREF. The generated data are thermodynamic properties and performance, such as COP (Coefficient of Performance) and VHE (Volumetric Heating Efficiency) values, from simulation of thermodynamic HP cycles with homemade software developed in Matlab environment.
DOI: 10.6084/m9.figshare.25062233
title: 20240126_starrydata2

description: All data on Starrydata2, a database of experimental properties in the field of inorganic materials
DOI: 10.6084/m9.figshare.25062233.v1
title: 20240126_starrydata2

description: All data on Starrydata2, a database of experimental properties in the field of inorganic materials
DOI: 10.6084/m9.figshare.25060217
title: Pre-contact and post-colonial ecological legacies shape Surinamese rainforests

description: This dataset belongs to the <i>Ecology</i> manuscript (ECY23-0681) "Pre-contact and post-colonial ecological legacies shape Surinamese rainforests". <b>Table S1</b> contains radiocarbon dating results (uncalibrated and calibrated age ranges and 1 sigma errors). <br><b>Table S2 </b>contains the phytolith morphotypes used that were used in the data analyses and fig.2-3, their corresponding plant taxa and literature <br><b>Table S3</b> contains CROSS 1 sizes, the count of CROSS and bilobate morphotypes and its ratio. In bold are extended counts<br><b>Table S4 </b>shows the data used to create fig. 2, showing phytoliths in abundances (%) or as "present" and charcoal in volume (cm3/mm3)<br><b>Table S5 </b>shows the data used to create fig. 3, showing burned phytoliths (%), total arboreal phytoliths (%), the openess index, total palm abundances (%) and modern AGB estimates for surface samples (Avitabile et al., 2016; Hijmans et al., 2013).<br><b>Table S6</b> contains the raw phytolith data in abundances (%) or as noted as "present", when observed during an extended scan. <b>Abstract of the manuscript:</b><br>Disturbances in tropical forests can have long-lasting ecological impacts, but their manifestations (ecological legacies) in modern forests are uncertain. Many Amazonian forests bear the mark of past soil modifications, species enrichments and fire events, but the trajectories of ecological legacies from the pre-contact or post-colonial period remains relatively unexplored. We assessed the fire and vegetation history from 15 soil cores ranging from 0 to 10 km from a post-colonial Surinamese archaeological site. We show that: i) fires occurred from 96 BC to recent times and induced significant vegetation change, ii) persistent ecological legacies from pre-contact and post-colonial fire and deforestation practices were mainly within 1 km of the archaeological site, and iii) palm enrichment of <i>Attalea</i>, <i>Oenocarpus</i> and <i>Astrocaryum</i> occurrewithin 0 km, 1 km, and 8 km of the archaeological site, respectively. Our results challenge the notion of spatially extensive and persistent ecological legacies. Instead, our data indicate that the persistence and extent of ecological legacies is dependent on its timing, frequency, type, and intensity. Examining the mechanisms and manifestations of ecological legacies is crucial in assessing forest resilience and Indigenous and local land rights in the highly threatened Amazonian forests.
DOI: 10.6084/m9.figshare.25062230
title: combosciplex

description: Combosciplex subset of sciplex v3
DOI: 10.5281/zenodo.10552069
title: Screw simulation results related to the throughput tests

description: Excel spreadsheets containing numeric simulation results with textual description.

These simulation results are related to the throughput tests and were created using non-isothermal network analysis.

They comprise the average pressure and average temperature as function of the screw speed and axial position.
DOI: 10.25345/c5m902d7s
title: MassIVE MSV000093920 - N-3-Methylbutyl-Benzisoselenazol-3(2H)-One exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
title: In the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibi-tory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-re-sistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is note-worthy that the concentration of N-3mb-bs observed to inhibit fungal growth by 50% (18.2 uM) was similar to the concentration observed to inhibit the activity of the yeast plasma membrane H+-ATPase (Pma1p) by 50% (19.6 uM). We next implemented a mouse model of vulvovaginal candidi-asis (VVC) using the S1 strain and examined the mouse and yeast proteins present in the vaginal lavage fluid using proteomics. The yeast proteins detected were predominately glycolytic enzymes or virulence factors associated with C. albicans while the mouse proteins present in the lavage fluid included eosinophil peroxidase, desmocollin-1 and gasdermin-A. We then utilized the N-3mb-bs compound (12.5 mg/kg) in the mouse VVC model and observed that it significantly reduced the vaginal fungal burden, histopathological changes in vagina tissue, and expression of myeloperoxi-dase (MPO). All in all, the present work has identified a potentially promising drug candidate for VVC treatment.
DOI: 10.6073/pasta/dd45022c823a25e8e76b1d68362d5f24
title: Synthesis of Hemlock Removal Experiment at Harvard Forest 2003-2019

description: In 2023, we synthesized the data from 6 Harvard Forest Hemlock Removal Experiment datasets (HF054, HF106, HF107, HF125, HF126 and HF161) to discern differences between the girdling and logging treatments from 2004-2019.
 Forest insect outbreaks cause large changes in ecosystem structure, composition, and function. Humans often respond to insect outbreaks by conducting salvage logging, which can amplify the immediate effects, but it is unclear whether logging will result in lasting differences in forest structure and dynamics when compared with forests affected only by insect outbreak. We used 15 years of data from an experimental removal of Tsuga canadensis (L.) Carr. (Eastern hemlock), a foundation tree species within eastern North American forests, and contrasted the rate, magnitude, and persistence of response trajectories between girdling (emulating mortality from insect outbreak) and timber harvest treatments.
DOI: 10.5517/ccdc.csd.cc292w1b
title: CCDC 2117921: Experimental Crystal Structure Determination

description: Related Article: Martin Nieger|2021|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2972h4
title: CCDC 2121965: Experimental Crystal Structure Determination

description: Related Article: Yafei Shi|2021|CSD Communication|||
description: Related Article: Yafei Shi, Chenglong Li, Hongwei Ma, Zhao Cao, Kanglei Liu, Xiaodong Yin, Nan Wang, Pangkuan Chen|2022|Org.Lett.|24|5497|doi:10.1021/acs.orglett.2c02344
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.