cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.10032815.v3
title: HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

description: A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic cellular and biological behaviors. In this study, we found that the expression level of HIF-1α in keloid tissue was significantly higher than that in the normal skin tissue. Hypoxia-induced HIF-1α expression significantly inhibited cellular apoptosis and promoted cellular proliferation in keloid fibroblasts but not in normal fibroblasts. Specifically, HIF-1α activated the TGF-β/Smad and TLR4/MyD88/NF-κB pathways, and the interaction of these two pathways may promote the development of keloids. Moreover, <i>in vivo</i> experiments showed that the inhibition of HIF-1α significantly reduced the growth of keloids.
DOI: 10.6084/m9.figshare.22615585.v1
title: Additional file 15 of Dynamics of rice microbiomes reveal core vertically transmitted seed endophytes

description: Additional file 15: Supplementary Table 6. Hub nodes revealed by ASV's Zi and Pi based on microhabitat variation.
DOI: 10.6084/m9.figshare.8984192.v1
title: Indocyanine Green Angiography for Continuously Monitoring Blood Flow Changes and Predicting Perfusion of Deep Inferior Epigastric Perforator Flap in Rats

description: Deep inferior epigastric perforator (DIEP) flap approach has excellent outcomes and low morbidity. However, it is associated with high rates of perfusion-related complications. To observe the blood flow changes and the stages of the flap perfusion, as well as the necrosis formation, we used indocyanine green (ICG) to monitor its perforators before and after DIEP flap harvesting. <i>Methods</i>: Abdominal perforator flaps supplied by the right superior abdominal perforating arteries were generated from seven SD rats. Laser-assisted ICG angiography was applied for dynamical and continuous observation of changes in the blood flow and courses of flap perfusion. Areas of flap perfusion were quantitatively analyzed using ImageJ. <i>Results</i>: The average perfusion area of the seven flaps after surgery and at days 1, 2, and 3 after surgery were 23.06 ± 2.47, 22.48 ± 2.04, 28.34 ± 1.14, and 28.97 ± 2.44 cm<sup>2</sup>, respectively. Compared to values after surgery, no significant difference was observed on day one (<i>p</i> &gt; 0.05); however, the flaps had significantly improved perfusion areas on day 2 (mean value of 5.28 ± 1.83 cm<sup>2</sup>, <i>p</i> &lt; 0.01) and day 3 (mean value of 5.91 ± 2.60 cm<sup>2</sup>, <i>p</i> &lt; 0.01) postsurgery. In addition, there were no significant differences between days 2 and 3 (<i>p</i> &gt; 0.05). The blood flow changes in both arteries and veins, the stages of flap perfusion, and the development of necrosis at the distal end of the flap were also observed. <i>Conclusion</i>: We gained valuable knowledge on the dynamic of blood flow changes and the course of flap perfusion inside the DIEP flap. Dynamic and continuous observation with ICG angiography through an SPY system is a powerful method for monitoring of blood supply in flaps that can be used to predict flap perfusion with a strong positive predictive significance.
DOI: 10.6084/m9.figshare.23664314.v1
title: Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers

description: West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis. A better understanding of the physiopathology associated with disease progression is mandatory to find biomarkers and effective therapies. In this scenario, blood derivatives (plasma and serum) constitute the more commonly used biofluids due to its ease of collection and high value for diagnostic purposes. Therefore, the potential impact of this virus in the circulating lipidome was addressed combining the analysis of samples from experimentally infected mice and naturally WND patients. Our results unveil dynamic alterations in the lipidome that define specific metabolic fingerprints of different infection stages. Concomitant with neuroinvasion in mice, the lipid landscape was dominated by a metabolic reprograming that resulted in significant elevations of circulating sphingolipids (ceramides, dihydroceramides, and dihydrosphingomyelins), phosphatidylethanolamines and triacylglycerols. Remarkably, patients suffering from WND also displayed an elevation of ceramides, dihydroceramides, lactosylceramides, and monoacylglycerols in their sera. The dysregulation of sphingolipid metabolism by WNV may provide new therapeutic opportunities and supports the potential of certain lipids as novel peripheral biomarkers of WND progression.
DOI: 10.6084/m9.figshare.6363002.v1
title: Additional file 7: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: Significantly differentially expressed miRNAs in pubescent and prepubescent goat pituitary. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6362957.v1
title: Additional file 5: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: Reads mapped to the goat reference genome in pubescent and prepubescent goat pituitary libraries. (XLS 75 kb)
DOI: 10.6084/m9.figshare.22615721
title: Additional file 2 of Barriers and facilitators to physical activity for young adult women: a systematic review and thematic synthesis of qualitative literature

description: Additional file 2.
DOI: 10.6084/m9.figshare.8984264.v1
title: Does successful surgical correction of childhood large angle exotropia in adults make any difference to binocularity and quality of life?

description: <b><i>Background/Aim</i></b>: Strabismus surgery could achieve motor alignment and improve health-related quality of life (HRQOL) in adults with large angle exotropia, but whether it could improve binocularity and whether the binocularity is associated with HRQOL are unknown. The aim of this study is to evaluate the binocularity and HRQOL following successful surgical correction of childhood large angle exotropia in adults. <b><i>Methods</i></b>: Consecutive adults with childhood large angle exotropia (≥90 prism diopters) who underwent strabismus surgery in the Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University were enrolled. Static and dynamic stereopsis tests were performed before surgery and 1 month after surgery. At the same time, Adult Strabismus-20 (AS-20), and Amblyopia and Strabismus questionnaire (A&SQ) were investigated. <b><i>Results</i></b>: A total of 29 adults achieved successful alignment: 18 intermittent exotropes (IXT) and 11 constant exotropes (CXT). One month after surgery, stereopsis was demonstrated better in all types of tests (<i>p</i> &lt; .05 for all comparisons). Twelve patients gained normal stereopsis. More patients in IXT group gained normal stereopsis than in CXT group (<i>x</i><sup>2</sup> = 7.62 <i>p</i> = .008). All HRQOL scores showed statistically significant improvement after surgery (<i>p</i> &lt; .05 for all comparisons). IXT group had more changes of the composite score (<i>t</i> = 2.24, <i>p</i> = .03) and the functional score (<i>t</i> = 2.92, <i>p</i> = .007) of AS-20, and the functional score (<i>t</i> = 3.06, <i>p</i>= .005) of A&SQ than CXT group. Only the change of the functional score of A&SQ was demonstrated a statistically significant correlation with the normal stereopsis (<i>t</i> = 2.67, <i>p</i> = .02). <b><i>Conclusions</i></b>: The stereopsis and HRQOL in adults with childhood large angle exotropia can be improved after successful surgical correction. More patients in IXT group gained normal stereopsis correlated with better functional aspects of HRQOL.
DOI: 10.5281/zenodo.10631396
title: Dataset related to article:COMBINING MULTI-SHELL DIFFUSION WITH CONVENTIONAL MRI IMPROVES MOLECULAR DIAGNOSIS OF DIFFUSE GLIOMAS WITH DEEP LEARNING

description: These are the Raw data of the test set results for the IDH mutation status (see Table 5 in the paper) and for the Subtype (see Table 6) classification performances in adult-type gliomas. These results were calculated in the outer loop of the nested cross-validation procedure for the deep learning model developed in this study. The results are reported for the model based only on conventional magnetic resonance (MR) images, only on multi-shell diffusion MR images, and based on the combination of conventional and multi-shell diffusion MR images.
DOI: 10.5281/zenodo.10631397
title: Dataset related to article:COMBINING MULTI-SHELL DIFFUSION WITH CONVENTIONAL MRI IMPROVES MOLECULAR DIAGNOSIS OF DIFFUSE GLIOMAS WITH DEEP LEARNING

description: These are the Raw data of the test set results for the IDH mutation status (see Table 5 in the paper) and for the Subtype (see Table 6) classification performances in adult-type gliomas. These results were calculated in the outer loop of the nested cross-validation procedure for the deep learning model developed in this study. The results are reported for the model based only on conventional magnetic resonance (MR) images, only on multi-shell diffusion MR images, and based on the combination of conventional and multi-shell diffusion MR images.
DOI: 10.6084/m9.figshare.6363002
title: Additional file 7: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: Significantly differentially expressed miRNAs in pubescent and prepubescent goat pituitary. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.22615585
title: Additional file 15 of Dynamics of rice microbiomes reveal core vertically transmitted seed endophytes

description: Additional file 15: Supplementary Table 6. Hub nodes revealed by ASV's Zi and Pi based on microhabitat variation.
DOI: 10.6084/m9.figshare.22607620
title: Additional file 5 of Parvimonas micra activates the Ras/ERK/c-Fos pathway by upregulating miR-218-5p to promote colorectal cancer progression

description: Additional file 5.
DOI: 10.6084/m9.figshare.22607623.v1
title: Additional file 6 of Parvimonas micra activates the Ras/ERK/c-Fos pathway by upregulating miR-218-5p to promote colorectal cancer progression

description: Additional file 6.
DOI: 10.6084/m9.figshare.22615591
title: Additional file 17 of Dynamics of rice microbiomes reveal core vertically transmitted seed endophytes

description: Additional file 17: Supplementary Table 8. Genomic characteristics of Pantoea and Xanthomonas isolates.
DOI: 10.6084/m9.figshare.20508638
title: Additional file 3 of Loss of glucosylceramide synthase impairs the growth and virulence of Fusarium oxysporum f. sp. cubense

description: Additional file 3: Table S3. Detailed information of differentially expressed genes.
DOI: 10.6084/m9.figshare.20508494.v1
title: Additional file 6 of The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA

description: Additional file 6: Table S6. List of NAT10-binding transcripts identified in NAT10 RIP-seq analysis.
DOI: 10.6084/m9.figshare.6362918.v1
title: Additional file 2: of Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep

description: Table S2. Summary of predicted of off-targets and de novo variants. (XLSX 587Â kb)
DOI: 10.6084/m9.figshare.23664314
title: Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers

description: West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis. A better understanding of the physiopathology associated with disease progression is mandatory to find biomarkers and effective therapies. In this scenario, blood derivatives (plasma and serum) constitute the more commonly used biofluids due to its ease of collection and high value for diagnostic purposes. Therefore, the potential impact of this virus in the circulating lipidome was addressed combining the analysis of samples from experimentally infected mice and naturally WND patients. Our results unveil dynamic alterations in the lipidome that define specific metabolic fingerprints of different infection stages. Concomitant with neuroinvasion in mice, the lipid landscape was dominated by a metabolic reprograming that resulted in significant elevations of circulating sphingolipids (ceramides, dihydroceramides, and dihydrosphingomyelins), phosphatidylethanolamines and triacylglycerols. Remarkably, patients suffering from WND also displayed an elevation of ceramides, dihydroceramides, lactosylceramides, and monoacylglycerols in their sera. The dysregulation of sphingolipid metabolism by WNV may provide new therapeutic opportunities and supports the potential of certain lipids as novel peripheral biomarkers of WND progression.
DOI: 10.6084/m9.figshare.6362957
title: Additional file 5: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: Reads mapped to the goat reference genome in pubescent and prepubescent goat pituitary libraries. (XLS 75 kb)
DOI: 10.6084/m9.figshare.6362978
title: Additional file 6: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: Unique sequences from the pituitary libraries of pubescent and prepubescent goat pituitary. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.8984264
title: Does successful surgical correction of childhood large angle exotropia in adults make any difference to binocularity and quality of life?

description: <b><i>Background/Aim</i></b>: Strabismus surgery could achieve motor alignment and improve health-related quality of life (HRQOL) in adults with large angle exotropia, but whether it could improve binocularity and whether the binocularity is associated with HRQOL are unknown. The aim of this study is to evaluate the binocularity and HRQOL following successful surgical correction of childhood large angle exotropia in adults. <b><i>Methods</i></b>: Consecutive adults with childhood large angle exotropia (≥90 prism diopters) who underwent strabismus surgery in the Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University were enrolled. Static and dynamic stereopsis tests were performed before surgery and 1 month after surgery. At the same time, Adult Strabismus-20 (AS-20), and Amblyopia and Strabismus questionnaire (A&SQ) were investigated. <b><i>Results</i></b>: A total of 29 adults achieved successful alignment: 18 intermittent exotropes (IXT) and 11 constant exotropes (CXT). One month after surgery, stereopsis was demonstrated better in all types of tests (<i>p</i> &lt; .05 for all comparisons). Twelve patients gained normal stereopsis. More patients in IXT group gained normal stereopsis than in CXT group (<i>x</i><sup>2</sup> = 7.62 <i>p</i> = .008). All HRQOL scores showed statistically significant improvement after surgery (<i>p</i> &lt; .05 for all comparisons). IXT group had more changes of the composite score (<i>t</i> = 2.24, <i>p</i> = .03) and the functional score (<i>t</i> = 2.92, <i>p</i> = .007) of AS-20, and the functional score (<i>t</i> = 3.06, <i>p</i>= .005) of A&SQ than CXT group. Only the change of the functional score of A&SQ was demonstrated a statistically significant correlation with the normal stereopsis (<i>t</i> = 2.67, <i>p</i> = .02). <b><i>Conclusions</i></b>: The stereopsis and HRQOL in adults with childhood large angle exotropia can be improved after successful surgical correction. More patients in IXT group gained normal stereopsis correlated with better functional aspects of HRQOL.
DOI: 10.6084/m9.figshare.6362978.v1
title: Additional file 6: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: Unique sequences from the pituitary libraries of pubescent and prepubescent goat pituitary. (XLSX 10 kb)
DOI: 10.6084/m9.figshare.6363020
title: Additional file 8: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: 73 novel miRNAs identified from pubescent and prepubescent goat pituitary. (XLS 30 kb)
DOI: 10.6084/m9.figshare.6362876
title: Additional file 1: of HPV-16, HPV-58, and HPV-33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix

description: Table S1. Original data of final diagnoses and quantitative PCR identification. (XLS 902 kb)
DOI: 10.6084/m9.figshare.6363113.v1
title: MOESM4 of Systems analysis of phosphate-limitation-induced lipid accumulation by the oleaginous yeast Rhodosporidium toruloides

description: Additional file 4: Table S4. Differentially expressed proteins between “P0” and “F3”.
DOI: 10.6084/m9.figshare.22615738
title: Additional file 5 of Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen–glucose deprivation conditions

description: Additional file 5: Table S4. Differentially Expressed Transcripts.
DOI: 10.6084/m9.figshare.22615729.v1
title: Additional file 2 of Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen–glucose deprivation conditions

description: Additional file 2: Table S1. Classification of DEGs.
DOI: 10.6084/m9.figshare.22615790
title: Additional file 8 of Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

description: Additional file 8: Table S2. Data of the compound screening.
DOI: 10.6084/m9.figshare.22615790.v1
title: Additional file 8 of Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

description: Additional file 8: Table S2. Data of the compound screening.
DOI: 10.6084/m9.figshare.22615787
title: Additional file 7 of Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

description: Additional file 7: Table S1. Primers for real-time PCR.
DOI: 10.6084/m9.figshare.22615787.v1
title: Additional file 7 of Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

description: Additional file 7: Table S1. Primers for real-time PCR.
DOI: 10.6084/m9.figshare.6362876.v1
title: Additional file 1: of HPV-16, HPV-58, and HPV-33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix

description: Table S1. Original data of final diagnoses and quantitative PCR identification. (XLS 902 kb)
DOI: 10.6084/m9.figshare.22615945.v1
title: Additional file 2 of Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction: a multicenter retrospective study of two large public databases

description: Additional file 2.
DOI: 10.6084/m9.figshare.22615945
title: Additional file 2 of Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction: a multicenter retrospective study of two large public databases

description: Additional file 2.
DOI: 10.6084/m9.figshare.22615948
title: Additional file 3 of Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction: a multicenter retrospective study of two large public databases

description: Additional file 3.
DOI: 10.6084/m9.figshare.22615948.v1
title: Additional file 3 of Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction: a multicenter retrospective study of two large public databases

description: Additional file 3.
DOI: 10.6084/m9.figshare.6362918
title: Additional file 2: of Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep

description: Table S2. Summary of predicted of off-targets and de novo variants. (XLSX 587Â kb)
DOI: 10.6084/m9.figshare.6363020.v1
title: Additional file 8: of Identification and characterization of microRNAs in the pituitary of pubescent goats

description: 73 novel miRNAs identified from pubescent and prepubescent goat pituitary. (XLS 30 kb)
DOI: 10.6084/m9.figshare.22615942
title: Additional file 1 of Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction: a multicenter retrospective study of two large public databases

description: Additional file 1.
DOI: 10.6084/m9.figshare.22615870
title: Additional file 2 of Transcriptomics reveals the molecular mechanisms of flesh colour differences in eggplant (Solanum melongena)

description: Additional file 2: Table S1. Data qualities statistics of RNA-seq in eggplant flesh.
DOI: 10.6084/m9.figshare.22615873.v1
title: Additional file 3 of Transcriptomics reveals the molecular mechanisms of flesh colour differences in eggplant (Solanum melongena)

description: Additional file 3: Table S2. DEGs between NC7 and BL.
DOI: 10.6084/m9.figshare.22615876.v1
title: Additional file 4 of Transcriptomics reveals the molecular mechanisms of flesh colour differences in eggplant (Solanum melongena)

description: Additional file 4: Table S3. Primers used in the q-PCR analysis.
DOI: 10.6084/m9.figshare.22607570
title: Additional file 3 of Prediction of protein solubility based on sequence physicochemical patterns and distributed representation information with DeepSoluE

description: Additional file 3: Table S4. Performance comparison of DeepSoluE and 11 conventional machine learning methods.
DOI: 10.6084/m9.figshare.22607570.v1
title: Additional file 3 of Prediction of protein solubility based on sequence physicochemical patterns and distributed representation information with DeepSoluE

description: Additional file 3: Table S4. Performance comparison of DeepSoluE and 11 conventional machine learning methods.
DOI: 10.6084/m9.figshare.22607707
title: Additional file 2 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes

description: Additional file 2.
DOI: 10.6084/m9.figshare.6363098
title: MOESM3 of Systems analysis of phosphate-limitation-induced lipid accumulation by the oleaginous yeast Rhodosporidium toruloides

description: Additional file 3: Table S3. Differentially expressed genes between “P0” and “F3”.
DOI: 10.6084/m9.figshare.22607710.v1
title: Additional file 3 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes

description: Additional file 3.
DOI: 10.6084/m9.figshare.22615906.v1
title: Additional file 1 of Influential factors and transcriptome analyses of immature diploid embryo anthocyanin accumulation in maize

description: Additional file 1: Supplementary Table S1. Annotation of DEGs identified in light vs dark.
DOI: 10.6084/m9.figshare.6363098.v1
title: MOESM3 of Systems analysis of phosphate-limitation-induced lipid accumulation by the oleaginous yeast Rhodosporidium toruloides

description: Additional file 3: Table S3. Differentially expressed genes between “P0” and “F3”.
DOI: 10.6084/m9.figshare.22615909
title: Additional file 2 of Influential factors and transcriptome analyses of immature diploid embryo anthocyanin accumulation in maize

description: Additional file 2: Supplementary Table S2. GO pathway analysis of DEGs under light.
DOI: 10.6084/m9.figshare.22615909.v1
title: Additional file 2 of Influential factors and transcriptome analyses of immature diploid embryo anthocyanin accumulation in maize

description: Additional file 2: Supplementary Table S2. GO pathway analysis of DEGs under light.