cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9699797.v1
title: Synthesis and Anti-inflammatory Evaluation of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-<i>a</i>]Pyrimidine, Imidazo[1,2-<i>b</i>]Pyrazole and Pyrazolo[5,1-<i>b</i>]Quinazoline Derivatives Containing Indane Moiety

description: A new series of pyrazole, pyrimidine, pyrazolo[1,5-<i>a</i>]pyrimidine, imidazo[1,2-<i>b</i>]pyrazole and pyrazolo[5,1-<i>b</i>]quinazoline derivatives containing indane moiety are prepared by using <i>N</i>-(2,3-dihydro-1<i>H</i>-inden-5-yl)carbonohydrazonoyl dicyanide (<b>2</b>) as starting material to synthetic different heterocyclic compounds (<b>3</b>–<b>11</b>) by the reaction with different bifuncation reagents. Moreover, 4-((2,3-dihydro-1<i>H</i>-inden-5-yl)diazenyl)-1<i>H-</i>pyrazole-3,5-diamine (<b>3</b>) was taken as a precursor to prepare different pyrazolo[1,5-<i>a</i>]pyrimidine derivatives (<b>12</b>–<b>20</b>). The structures of newly synthesized compounds were confirmed on the basis of their IR, 1H NMR, 13C NMR, and mass spectral data. All compounds were evaluated as anti-inflammatory activity by using carrageenan-induced rat paw edema test. In comparison to the standard drug diclofenac sodium, compounds <b>3</b>, <b>7</b>, <b>9</b>, and <b>11</b> exhibited potent activity than standard drug. The compounds <b>2</b> and <b>8</b> showed the most significant anti- anti-inflammatory with 64.83 and 63.95% inhibition of edema.
DOI: 10.6084/m9.figshare.9699275
title: Efficacy of <i>λ</i>-cyhalothrin, amitraz, and phoxim against the poultry red mite <i>Dermanyssus gallinae</i> De Geer, 1778 (Mesostigmata: Dermanyssidae): an eight-year survey

description: <i>Dermanyssus gallinae</i> (De Geer, 1778) is a major problem for the poultry industry worldwide, as it negatively affects virtually all kinds of rearing systems. Therefore, the control of infestation has become a routine process, and its economic cost is constantly increasing. Until now, most of the control strategies have relied on the use of synthetic chemical drugs, but their efficacy is often questioned by the emergence and diffusion of resistant mite populations. With this in mind, the efficacy of <i>λ</i>-cyhalothrin, amitraz, and phoxim has been verified by testing them against 86 mite populations collected from the same number of poultry farms in Italy from 2008 to 2015. Assays were performed according to the filter paper method using the recommended, half, quarter, double and quadruple doses. The results showed that phoxim and amitraz were the most effective acaricides (median efficacies 80.35% and 80.83%, respectively), but amitraz exhibited a sharp fall in its efficacy during 2011 and 2012, while phoxim maintained its high effectiveness up to 2015, when it dropped. The overall median efficacy of <i>λ</i>-cyhalothrin was 58.33%. The data also highlighted the importance of the use of the right concentration, as an increase in dosage was not always useful against resistant populations, while its reduction also diminished efficacy, simultaneously increasing the risk for the development of resistance.
DOI: 10.6084/m9.figshare.9699287
title: Supplementary Material for: Costs Attributable to Arteriovenous Fistula and Arteriovenous Graft Placements in Hemodialysis Patients with Medicare coverage

description: <b><i>Introduction:</i></b> Hemodialysis (HD) in end-stage renal disease (ESRD) patients requires vascular access (VA) through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter. While AVF or AVG is commonly used for HD, the economic implications of AVF versus AVG use have not been fully established. We describe the healthcare resource utilization and costs of AVF and AVG use for incident ESRD patients in the United States. <b><i>Methods:</i></b> This observational cohort study of AVF and AVG placements used data from the United States Renal Data System to identify and follow access placements. AVF and AVG placements after ESRD onset for incident patients from 2012 to 2014 with continuous Medicare primary coverage were included. All-cause and access-related Medicare costs were averaged over the placement lifetime and expressed as per dialysis-month costs. <b><i>Results:</i></b> The analysis included 38,035 AVF placements and 12,789 AVG placements. Total all-cause monthly costs for AVF averaged USD 8,508; mean monthly costs were USD 3,027 for inpatient (IP), USD 3,139 for outpatient (OP), USD 1,572 for physician services, and USD 770 for other care settings. Access-related monthly costs averaged USD 1,699 and represented 20% of all-cause charges for AVFs. Mean all-cause monthly costs for AVG were USD 9,605; by setting monthly costs were USD 3,811 for IP, USD 3,034 for OP, USD 1,881 for physician services and USD 879 for other care settings. Access-related monthly costs averaged USD 2,656 and represented 28% of all-cause charges for AVGs. <b><i>Discussion/Conclusions:</i></b> This study indicates that costs due to VA are a significant burden on Medicare budgets and on patients. The factors driving access-related utilization and costs merit attention in future research. Both optimizing process of care and discovery innovation may significantly accelerate better stewardship of available healthcare resources.
DOI: 10.6084/m9.figshare.9699275.v1
title: Efficacy of <i>λ</i>-cyhalothrin, amitraz, and phoxim against the poultry red mite <i>Dermanyssus gallinae</i> De Geer, 1778 (Mesostigmata: Dermanyssidae): an eight-year survey

description: <i>Dermanyssus gallinae</i> (De Geer, 1778) is a major problem for the poultry industry worldwide, as it negatively affects virtually all kinds of rearing systems. Therefore, the control of infestation has become a routine process, and its economic cost is constantly increasing. Until now, most of the control strategies have relied on the use of synthetic chemical drugs, but their efficacy is often questioned by the emergence and diffusion of resistant mite populations. With this in mind, the efficacy of <i>λ</i>-cyhalothrin, amitraz, and phoxim has been verified by testing them against 86 mite populations collected from the same number of poultry farms in Italy from 2008 to 2015. Assays were performed according to the filter paper method using the recommended, half, quarter, double and quadruple doses. The results showed that phoxim and amitraz were the most effective acaricides (median efficacies 80.35% and 80.83%, respectively), but amitraz exhibited a sharp fall in its efficacy during 2011 and 2012, while phoxim maintained its high effectiveness up to 2015, when it dropped. The overall median efficacy of <i>λ</i>-cyhalothrin was 58.33%. The data also highlighted the importance of the use of the right concentration, as an increase in dosage was not always useful against resistant populations, while its reduction also diminished efficacy, simultaneously increasing the risk for the development of resistance.
DOI: 10.6084/m9.figshare.9699287.v1
title: Supplementary Material for: Costs Attributable to Arteriovenous Fistula and Arteriovenous Graft Placements in Hemodialysis Patients with Medicare coverage

description: <b><i>Introduction:</i></b> Hemodialysis (HD) in end-stage renal disease (ESRD) patients requires vascular access (VA) through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter. While AVF or AVG is commonly used for HD, the economic implications of AVF versus AVG use have not been fully established. We describe the healthcare resource utilization and costs of AVF and AVG use for incident ESRD patients in the United States. <b><i>Methods:</i></b> This observational cohort study of AVF and AVG placements used data from the United States Renal Data System to identify and follow access placements. AVF and AVG placements after ESRD onset for incident patients from 2012 to 2014 with continuous Medicare primary coverage were included. All-cause and access-related Medicare costs were averaged over the placement lifetime and expressed as per dialysis-month costs. <b><i>Results:</i></b> The analysis included 38,035 AVF placements and 12,789 AVG placements. Total all-cause monthly costs for AVF averaged USD 8,508; mean monthly costs were USD 3,027 for inpatient (IP), USD 3,139 for outpatient (OP), USD 1,572 for physician services, and USD 770 for other care settings. Access-related monthly costs averaged USD 1,699 and represented 20% of all-cause charges for AVFs. Mean all-cause monthly costs for AVG were USD 9,605; by setting monthly costs were USD 3,811 for IP, USD 3,034 for OP, USD 1,881 for physician services and USD 879 for other care settings. Access-related monthly costs averaged USD 2,656 and represented 28% of all-cause charges for AVGs. <b><i>Discussion/Conclusions:</i></b> This study indicates that costs due to VA are a significant burden on Medicare budgets and on patients. The factors driving access-related utilization and costs merit attention in future research. Both optimizing process of care and discovery innovation may significantly accelerate better stewardship of available healthcare resources.
DOI: 10.6084/m9.figshare.9699143
title: Environmental DNA size sorting and degradation experiment indicates the state of Daphnia magna mitochondrial and nuclear eDNA is subcellular

description: Data for the titled publication including Time (day), Tank (replicate) and qunatification for the COI and 18S (qpcr copy numbers) and qubit (ng/ul) for the full experimental design
DOI: 10.6084/m9.figshare.9699143.v1
title: Environmental DNA size sorting and degradation experiment indicates the state of Daphnia magna mitochondrial and nuclear eDNA is subcellular

description: Data for the titled publication including Time (day), Tank (replicate) and qunatification for the COI and 18S (qpcr copy numbers) and qubit (ng/ul) for the full experimental design
DOI: 10.6084/m9.figshare.9699107
title: Trends in Community Temperature Index values for North Pacific and North Atlantic bottom trawl and plankton surveys for 2° latitude/longitude boxes from 1985 to 2014.

description: Values given are regression coefficients for trends in CTI plus covariates. Variables are described in the accompanying file.<br>Data supports: Burrows, M. T., A. E. Bates, M. J. Costello, M. Edwards, G. J. Edgar, C. J. Fox, B. S. Halpern, J. G. Hiddink, M. L. Pinsky, R. D. Batt, J. García Molinos, B. Payne, D. Schoeman, R. D. Stuart-Smith, and E. S. Poloczanska. 2018. Thermal affinities and vertical temperature gradients explain responses to warming in ocean communities. Nature Climate Change, in review.
DOI: 10.6084/m9.figshare.9699107.v1
title: Trends in Community Temperature Index values for North Pacific and North Atlantic bottom trawl and plankton surveys for 2° latitude/longitude boxes from 1985 to 2014.

description: Values given are regression coefficients for trends in CTI plus covariates. Variables are described in the accompanying file.<br>Data supports: Burrows, M. T., A. E. Bates, M. J. Costello, M. Edwards, G. J. Edgar, C. J. Fox, B. S. Halpern, J. G. Hiddink, M. L. Pinsky, R. D. Batt, J. García Molinos, B. Payne, D. Schoeman, R. D. Stuart-Smith, and E. S. Poloczanska. 2018. Thermal affinities and vertical temperature gradients explain responses to warming in ocean communities. Nature Climate Change, in review.
DOI: 10.6084/m9.figshare.9699068
title: Community Temperature Index values for North Pacific and North Atlantic bottom trawls and plankton in 2° latitude/longitude areas annually from 1985 to 2014

description: Data to support Burrows, M. T., A. E. Bates, M. J. Costello, M. Edwards, G. J. Edgar, C. J. Fox, B. S. Halpern, J. G. Hiddink, M. L. Pinsky, R. D. Batt, J. García Molinos, B. Payne, D. Schoeman, R. D. Stuart-Smith, and E. S. Poloczanska. 2018. Thermal affinities and vertical temperature gradients explain recent responses to warming in ocean communities. Nature Climate Change, in review.<br>
DOI: 10.6084/m9.figshare.9699071
title: Supplementary Material for: Changes in Cytokines, Haemodynamics and Microcirculation in Patients with Sepsis/Septic Shock Undergoing Continuous Renal Replacement Therapy and Blood Purification with CytoSorb

description: <b><i>Background:</i></b> Extracorporeal blood purification therapies have been proposed as a strategy to remove inflammatory mediators during sepsis, thus improving outcome. <b><i>Objectives:</i></b> We aimed to evaluate changes in cytokines, haemodynamics and microcirculation during blood purification with Cytosorb adsorber in septic patients. <b><i>Methods:</i></b> Prospective observational study on critically ill adult patients with sepsis/septic shock underwent renal replacement therapy (RRT) for acute renal failure and haemoadsorption with Cytosorb as adjunctive therapy for 24 h. Measurements were taken at baseline, after 6 and 24 h: haemodynamic parameters, arterial and central venous blood gases, plasma levels of tumour necrosis factor alpha, interleukin (IL) 1-beta, IL-6, IL-8 and IL-10. The sublingual microcirculation was assessed with sidestream dark field videomicroscopy to evaluate the perfused vessel density (PVD) and microvascular flow quality. Tissue oxygenation and microvascular reactivity were assessed with thenar near infrared spectroscopy (NIRS) with a vascular occlusion test. <b><i>Results:</i></b> Nine patients; plasma levels of IL-8 decreased at 24 h (<i>p</i> &lt; 0.05 versus 6 h); no significant variation was found for other cytokines. Haemodynamic remained stable throughout the observation. Microvascular perfusion improved over time, with an increase in PVDs at 6 and 24 h (from 13.9 [13.3–16.4] to 15.7 [15–17.3] and 17 [14.8–18.6] mm/mm<sup>2</sup> respectively, <i>p</i> = 0.003) and total vessel densities at 24 h (14.9 [13.9–16.9] vs. 17.9 [15.3–20], <i>p</i> = 0.0015). No significant variation was detected in NIRS-derived parameters. The Sequential Organ Failure Assessment score decreased from 12 ± 3 to 10 ± 1 at 24 h (<i>p</i> = 0.039). <b><i>Conclusions:</i></b> In septic patients undergoing RRT, haemoadsorption with Cytosorb seems to determine a decreasing in plasma levels of IL-8, although levels of other cytokines did not vary significantly, and an improvement of microcirculation despite no significant variation in macro-haemodynamics.
DOI: 10.6084/m9.figshare.9698978
title: Supplementary Table S1 from Spatio-temporal ecological niche modelling of multigenerational insect migrations

description: Breeding records dataset used for niche modelling
DOI: 10.6084/m9.figshare.9699131.v1
title: Data from: Plant physical and chemical traits associated to herbivory in situ and under a climate warming treatment.

description: <b>When using these datasets, please cite the following reference: </b>Descombes et al. (2019)... <br><br>Details on the data sampling are fully described in the aforementioned reference.<br>Data.txt: This dataset contains...
DOI: 10.6084/m9.figshare.9698978.v1
title: Supplementary Table S1 from Spatio-temporal ecological niche modelling of multigenerational insect migrations

description: Breeding records dataset used for niche modelling
DOI: 10.6084/m9.figshare.9699131.v2
title: Data from: Plant physical and chemical traits associated to herbivory in situ and under a warming treatment.

description: <b>When using these datasets, please cite the following reference: </b>Descombes et al. (2019)... <br><br>Details on the data sampling are fully described in the aforementioned reference.<br>Data.txt: This dataset contains...
DOI: 10.6084/m9.figshare.9699131.v3
title: Data from: Plant physical and chemical traits associated to herbivory in situ and under a warming treatment.

description: <b>===============================================</b><br><b>===============================================<br></b><b>===============================================<br></b><b><br></b><b>When using these datasets, please cite the following references: </b><br><br>Descombes, P., Kergunteuil, A., Glauser, G., Rasmann, S., & Pellissier, L. (2019). Plant physical and chemical traits associated with herbivory in situ and under a warming treatment. <i>Journal of Ecology</i>.<br>Descombes, P., Kergunteuil, A., Glauser, G., Rasmann, S. & Pellissier, L. (2019).Data from: Plant physical and chemical traits associated to herbivory in situ and under a warming treatment.<i> Figshare</i>, https://doi.org/10.6084/m9.figshare.9699131<br><b>===============================================<br></b><b>===============================================<br></b><b>===============================================<br></b><b><br></b><b>Datasets descriptions:<br></b><b><br></b>Details on the data sampling are fully described in the aforementioned references.<br>Data_Herbivory_Palatabilty.txt: This dataset contains the plant traits and plant palatability (by Spodoptera) assessed for the plant species occurring on 3 grasslands in the Alps. This dataset was used for modeling the herbivory by Spodoptera. <br><br> Data_Herbivory_Natural.txt: This dataset contains the plant traits and plant herbivory (by natural herbivores) assessed in plots for the plant species occurring on 3 grasslands in the Alps. This dataset was used for modeling the herbivory by natural herbivores.<br><br>Data_Warming.treatement.txt: This dataset contains the plant traits and plant palatability (by spodoptera) assessed for samples collected in plots under an ambiant control and a warming treatement. This dataset was used for modeling the changes in plant traits between the control and warming treatments, and for assessing changes in plant palatability (by Spodoptera) associated with changes in leaf traits. <br><br>Columns are described in the respective readme files.<br>
DOI: 10.5517/ccdc.csd.cc256wz8
title: CCDC 2002630: Experimental Crystal Structure Determination

description: Related Article: Chrisoula Kakoulidou, Panagiotis S. Gritzapis, Antonios G. Hatzidimitriou, Konstantina C. Fylaktakidou, George Psomas|2020|J.Inorg.Biochem.|211|111194|doi:10.1016/j.jinorgbio.2020.111194
DOI: 10.6084/m9.figshare.9698939
title: Supplementary Material for: Stroke Factors Associated with Thrombolysis Use in Hospitals in Singapore and US: A Cross-Registry Comparative Study

description: <b><i>Background and Objectives:</i></b> This paper aims to describe and compare the characteristics of 2 stroke populations in Singapore and in St. Louis, USA, and to document thrombolysis rates and contrast factors associated with its uptake in both populations. <b><i>Methods:</i></b> The stroke populations described were from the Singapore Stroke Registry (SSR) in ­Singapore and the Cognitive Rehabilitation Research Group Stroke Registry (CRRGSR) in St. Louis, MO, USA. The registries were compared in terms of demographics and stroke risk factor history. Logistic regression was used to determine factors associated with thrombolysis uptake. <b><i>Results:</i></b> A total of 39,323 and 8,106 episodes were recorded in SSR and CRRGSR, respectively, from 2005 to 2012. Compared to CRRGSR, patients in SSR were older, male, and from the ethnic majority. Thrombolysis rates in SSR and CRRGSR were 2.5 and 8.2%, respectively, for the study period. History of ischemic heart disease or atrial fibrillation was associated with increased uptake in both populations, while history of stroke was associated with lower uptake. For SSR, younger age and males were associated with increased uptake, while having a history of smoking or diabetes was associated with decreased uptake. For CRRGSR, ethnic minority status was associated with decreased uptake. <b><i>Conclusions:</i></b> The comparison of stroke populations in Singapore and St Louis revealed distinct differences in clinicodemographics of the 2 groups. Thrombolysis uptake was driven by nonethnicity demographics in Singapore. Ethnicity was the only demographic driver of uptake in the CRRGSR population, highlighting the need to target ethnic minorities in increasing access to thrombolysis.
DOI: 10.6084/m9.figshare.9698939.v1
title: Supplementary Material for: Stroke Factors Associated with Thrombolysis Use in Hospitals in Singapore and US: A Cross-Registry Comparative Study

description: <b><i>Background and Objectives:</i></b> This paper aims to describe and compare the characteristics of 2 stroke populations in Singapore and in St. Louis, USA, and to document thrombolysis rates and contrast factors associated with its uptake in both populations. <b><i>Methods:</i></b> The stroke populations described were from the Singapore Stroke Registry (SSR) in ­Singapore and the Cognitive Rehabilitation Research Group Stroke Registry (CRRGSR) in St. Louis, MO, USA. The registries were compared in terms of demographics and stroke risk factor history. Logistic regression was used to determine factors associated with thrombolysis uptake. <b><i>Results:</i></b> A total of 39,323 and 8,106 episodes were recorded in SSR and CRRGSR, respectively, from 2005 to 2012. Compared to CRRGSR, patients in SSR were older, male, and from the ethnic majority. Thrombolysis rates in SSR and CRRGSR were 2.5 and 8.2%, respectively, for the study period. History of ischemic heart disease or atrial fibrillation was associated with increased uptake in both populations, while history of stroke was associated with lower uptake. For SSR, younger age and males were associated with increased uptake, while having a history of smoking or diabetes was associated with decreased uptake. For CRRGSR, ethnic minority status was associated with decreased uptake. <b><i>Conclusions:</i></b> The comparison of stroke populations in Singapore and St Louis revealed distinct differences in clinicodemographics of the 2 groups. Thrombolysis uptake was driven by nonethnicity demographics in Singapore. Ethnicity was the only demographic driver of uptake in the CRRGSR population, highlighting the need to target ethnic minorities in increasing access to thrombolysis.
DOI: 10.6084/m9.figshare.9698771
title: Supplementary Mathematica File from A sheep in wolf’s clothing: levels of deceit and detection in the evolution of cue-mimicry

description: Detailed calculations, analysis, and code for generating the figures
DOI: 10.5517/ccdc.csd.cc257jcb
title: CCDC 2003231: Experimental Crystal Structure Determination

description: Related Article: Valentina Milašinović, Anna Krawczuk, Krešimir Molčanov, Biserka Kojić-Prodić|2020|Cryst.Growth Des.|20|5435|doi:10.1021/acs.cgd.0c00658
DOI: 10.6084/m9.figshare.9698771.v1
title: Supplementary Mathematica File from A sheep in wolf’s clothing: levels of deceit and detection in the evolution of cue-mimicry

description: Detailed calculations, analysis, and code for generating the figures
DOI: 10.5517/ccdc.csd.cc1pjt01
title: CCDC 1565283: Experimental Crystal Structure Determination

description: Related Article: Samia Benmansour, Antonio Hernández-Paredes, Arpan Mondal, Gustavo López Martínez, Josep Canet-Ferrer, Sanjit Konar, Carlos J. Gómez-García|2020|Chem.Commun.|56|9862|doi:10.1039/D0CC03964K
DOI: 10.5517/ccdc.csd.cc259ljm
title: CCDC 2005220: Experimental Crystal Structure Determination

description: Related Article: Samia Benmansour, Antonio Hernández-Paredes, Arpan Mondal, Gustavo López Martínez, Josep Canet-Ferrer, Sanjit Konar, Carlos J. Gómez-García|2020|Chem.Commun.|56|9862|doi:10.1039/D0CC03964K
DOI: 10.6084/m9.figshare.9698756
title: Data: Telemetry data of juvenile little owls from Experimentally disentangling intrinsic and extrinsic drivers of natal dispersal in a nocturnal raptor

description: Telemetry data of juvenile little owls
DOI: 10.6084/m9.figshare.9698759
title: Data: Dispersal variables of juvenile little owls from Experimentally disentangling intrinsic and extrinsic drivers of natal dispersal in a nocturnal raptor

description: Dispersal variables of juvenile little owls
DOI: 10.5517/ccdc.csd.cc25byr7
title: CCDC 2006529: Experimental Crystal Structure Determination

description: Related Article: Markus F. K. Trautnitz, Tobias Haas, Hartmut Schubert, Michael Seitz|2020|Chem.Commun.|56|9874|doi:10.1039/D0CC04050A
DOI: 10.5517/ccdc.csd.cc25bys8
title: CCDC 2006530: Experimental Crystal Structure Determination

description: Related Article: Markus F. K. Trautnitz, Tobias Haas, Hartmut Schubert, Michael Seitz|2020|Chem.Commun.|56|9874|doi:10.1039/D0CC04050A