cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21608186.v1
title: Chemotherapy plus panitumumab/cetuximab versus chemotherapy plus bevacizumab in wild-type KRAS/RAS metastatic colorectal cancer: a meta-analysis

description: It remains controversial which targeted monoclonal antibodies combined with chemotherapy can provide better efficacy in wild-type KRAS/RAS metastatic colorectal cancer (mCRC) patients. Therefore, we used this meta-analysis to assess the latest evidence of clinical outcomes. We systematically searched PubMed, Web of Science, Cochrane Library and Embase databases for eligible studies published from database inception to May 2022. RevMan 5.4 was used to conduct the meta-analysis. 11 RCTs involving a total of 3575 patients were included. Meta-analysis showed that EGFR inhibitors significantly prolonged the overall survival (OS) [HR = 0.83, 95%CI (0.73, 0.94), <i>P</i> = 0.003] and overall response rate (ORR) [RR = 1.11, 95%CI (1.05, 1.18), <i>P</i> = 0.0003] compared to VEGF inhibitors in wild-type KRAS/RAS mCRC patients, but no significant difference in progression-free survival (PFS) [HR = 0.96, 95%CI (0.87, 1.07), <i>P</i> = 0.50]. In subgroup analysis, the survival benefit of EGFR inhibitors was limited to first-line treatment. Our study showed that EGFR inhibitors were superior to VEGF inhibitors in wild-type KRAS/RAS mCRC patients, especially in patients with first-line treatment. However, subsequent large sample, multi-center RCTs are needed to further verify our conclusions.
DOI: 10.6084/m9.figshare.22132328.v1
title: Hybrid Transthoracic Periventricular Device Closure of Ventricular Septal Defects: Single-Center Experience

description: Abstract Objective: To evaluate the efficacy of hybrid transthoracic periventricular device closure of ventricular septal defects (VSDs) in a single center. Methods: All patients who underwent hybrid transthoracic periventricular device closure of VSDs between January 2018 and December 2019 were retrospectively analyzed. The preoperative, operative and postoperative findings and clinical follow-ups were reviewed. Results: A total of 59 patients underwent the procedure. Transesophageal echocardiographic guidance was used in all procedures. The procedure was successful in 57 procedures (97%). The procedures of two patients were changed to open-heart surgery during the same intervention due to severe aortic insufficiency (the device was not deployed) and significant residual shunt after device deployment. One major complication (1.7%) was observed after the procedure. The patient’s device was dislodged within 12 hours after the procedure, and this patient underwent device extraction and VSD patch closure due to significant residual shunt. Eight (14%) minor complications were observed after the procedure, and three of them persisted during follow-up. Three of these eight complications were incomplete right bundle branch block, one of which resolved during follow-up; two were mild residual shunts, one of which resolved during follow-up; two were mild new-onset tricuspid valve insufficiencies; and one was mild new-onset mitral valve insufficiency; all valvular insufficiencies were resolved during follow-up. Conclusions: Hybrid transthoracic periventricular device closure of VSD seems to be a good alternative approach due to its procedural success and low risk rates. The best advantage of the procedure is the possibility of switching to open-heart surgery, if necessary.
DOI: 10.6084/m9.figshare.14791693.v1
title: Genetic polymorphisms of 16 X-STR loci in the Hani population from Southwest China

description: X chromosomal short tandem repeats (X-STRs) have the characteristics of both autosomal and uniparental genetic markers and have been shown to be particularly useful in forensic casework. However, relevant research or reports have not focused on X-STRs in the Hani population. To investigate the genetic variation and forensic efficiency of 16 X-STR loci in the Hani ethnic minority, we calculated the allele frequencies and forensic parameters of 451 (116 males and 335 females) unrelated healthy Hani individuals from Yunnan Province, Southwest China. All these loci are highly polymorphic in Hani individuals in Yunnan Province except DXS6800. The combined power of discrimination in males (PD<sub>M</sub>) and power of discrimination in females (PD<sub>F</sub>) were found to be 0.999 999 998 433 993 and 0.999 999 999 999 998, respectively. Furthermore, a population genetic structure investigation between the Yunnan Hani population and another 18 populations was performed using a principal component analysis, multidimensional scaling plot and neighbouring-joining phylogenetic tree and the findings illustrated that neighbouring populations and different nationalities in the same area appeared to have a closer evolutionary relationship. This study provides the first batch of X chromosome genetic polymorphism data of the Hani population in Yunnan Province, Southwest China and enriches the reference database of the Chinese minority population. This is the first study of X-STR in the Hani population. We calculated the allele frequencies and forensic parameters of 451 unrelated healthy Hani individuals from Yunnan Province, Southwest China. All these loci are highly polymorphic in Hani individuals in Yunnan Province except DXS6800. The genetic relationship between the Hani and the other 18 nationalities was analyzed. This study provides the first batch of X chromosome genetic polymorphism data of the Hani population in Yunnan Province, Southwest China and enriches the reference database of the Chinese minority population.
DOI: 10.6084/m9.figshare.19510895.v1
title: Mitochondrial genome structure, phylogenetic analyses and substitution rate estimation of the Oedogoniales

description: The order Oedogoniales comprises three genera, <i>Oedogonium, Oedocladium</i> and <i>Bulbochaete</i>, which were classified based on traditional morphological criteria, and includes more than 600 described species. This group is economically important in astaxanthin production and the energy sector. However, only one mitochondrial genome (mitogenome) has been reported so far. This study determined the mitochondrial genomes of seven Oedogoniales species, including six <i>Oedogonium</i> species and <i>Oedocladium prescottii</i>. Comparative analyses between the newly determined mitogenomes and the previously reported <i>Bulbochaete rectangularis</i> var. <i>hiloensis</i> mitogenome showed that all eight mitogenomes comprised 12 protein-coding genes (PCGs) and two rRNAs; however, the mitogenomes differed in their genome sizes, GC content, tRNAs, non-coding regions and introns. Synteny analysis of the eight mitogenomes revealed a high degree of syntenic conservation in general, with some rearrangements and inversions. The average nucleotide identity (ANI) analysis of the eight mitogenomes indicated <i>Oedogonium dentireticulatum</i> showed high similarity with <i>Oedogonium</i> sp3 (ANI of 96.32%). Most of the PCGs of the eight mitogenomes presented the conventional start codon ATG and stop codon TAR (TAA/TAG/TGA), and the synonymous codon preferences were conserved. Phylogenetic results indicated that <i>Oedogonium</i> was polyphyletic, and species of <i>Oedocladium</i> clustered with <i>Oedogonium</i>, while the position of <i>B. rectangularis</i> var. <i>hiloensis</i> was uncertain for the incongruent phylogenetic results. Statistical analyses of substitution rates demonstrated no significant differences among the three genera, and the dN/dS ratios based on branch model showed that <i>cob, cox</i>1 and <i>nad</i>4 of <i>Oedocladium prescottii</i> and <i>B. rectangularis</i> var. <i>hiloensis</i> were putative fast-evolving genes. These findings suggested that the traditional taxonomy of Oedogoniales did not define natural groups, and that species of <i>Oedocladium</i> and <i>Bulbochaete</i> may have undergone rapid evolution.
DOI: 10.6084/m9.figshare.22132338.v1
title: Research Status of SARS-CoV-2 on Cardiovascular System Injury in Children

description: Abstract In December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began to break out in the Hubei Province of China. At present, the epidemic situation in the world continues and the number of confirmed cases is increasing every day. A recent review showed that children under the age of ten years make up about 1% of the infected population, which cannot be ignored. Studies have shown that after SARS-CoV-2 infection children can show clinical symptoms of cardiovascular system damage in addition to typical respiratory symptoms. This article mainly discusses the possible damage of SARS-CoV-2 to children's cardiovascular system and related mechanisms.
DOI: 10.6084/m9.figshare.7981559
title: Early Paleozoic granitoids from South China: implications for understanding the Wuyi-Yunkai orogen

description: The early Paleozoic Wuyi-Yunkai orogeny involves voluminous magmatism and represents the first major tectonothermal event in the South China block since the Neoproterozoic break-up of the Rodinia supercontinent. Here we investigate three representative granitic plutons in Guangxi province of southwest China with a view to understand the magmatic response of the Wuyi-Yunkai orogeny. We present the results of major and trace elements, Sr-Nd isotopes, zircon U-Pb ages and Hf isotope. LA-ICPMS zircon U-Pb geochronology reveals that these plutons emplaced during the early Silurian (441–432 Ma), overlapping with the reported ages of the early Paleozoic magmatism in this orogen. Among the three plutons investigated in this study, the Qinjia pluton is characterized by weakly to strongly peraluminous (A/CNK = 1.0–1.2) nature with SiO<sub>2</sub> content varing from 70.6 to 72.3 wt.%. Combined with the relatively high ε<sub>Nd</sub>(t) values (−4.9 to −4.2) and ε<sub>Hf</sub>(t) values (−2.9 to +6.1), the Qinjia pluton is thought to derive from partial melting of metasedimentary and metabasic rocks and there may exsit juvenile components in magma source. The Damingshan porphyritic granites (SiO<sub>2</sub> = 74.8–76.5 wt.%) and Yingqiao granites (SiO<sub>2</sub> = 76.5–76.6 wt.%) are strongly peraluminous (A/CNK = 1.1–1.6) and they have negative zircon ε<sub>Hf</sub>(t) values (−6.8 to −4.2, −12.8 to −6.1, respectively) and whole-rock ε<sub>Nd</sub>(t) values (−6.3 to −6.2, −8.4, respectively). These signatures indicate that the Damingshan and Yingqiao plutons were derived from partial melting of ancient metasedimentary rocks. Combining our data with those from previous studies on the magmatic, sedimentary and metamorphic records of this area, we suggest that the early Paleozoic magmatism is likely associated with lithospheric delamination and the Wuyi-Yunkai orogen is an intracontinental orogen linked to the far-field response to the assembly of the South China block with the Gondwana in the early Paleozoic.
DOI: 10.6084/m9.figshare.7981559.v1
title: Early Paleozoic granitoids from South China: implications for understanding the Wuyi-Yunkai orogen

description: The early Paleozoic Wuyi-Yunkai orogeny involves voluminous magmatism and represents the first major tectonothermal event in the South China block since the Neoproterozoic break-up of the Rodinia supercontinent. Here we investigate three representative granitic plutons in Guangxi province of southwest China with a view to understand the magmatic response of the Wuyi-Yunkai orogeny. We present the results of major and trace elements, Sr-Nd isotopes, zircon U-Pb ages and Hf isotope. LA-ICPMS zircon U-Pb geochronology reveals that these plutons emplaced during the early Silurian (441–432 Ma), overlapping with the reported ages of the early Paleozoic magmatism in this orogen. Among the three plutons investigated in this study, the Qinjia pluton is characterized by weakly to strongly peraluminous (A/CNK = 1.0–1.2) nature with SiO<sub>2</sub> content varing from 70.6 to 72.3 wt.%. Combined with the relatively high ε<sub>Nd</sub>(t) values (−4.9 to −4.2) and ε<sub>Hf</sub>(t) values (−2.9 to +6.1), the Qinjia pluton is thought to derive from partial melting of metasedimentary and metabasic rocks and there may exsit juvenile components in magma source. The Damingshan porphyritic granites (SiO<sub>2</sub> = 74.8–76.5 wt.%) and Yingqiao granites (SiO<sub>2</sub> = 76.5–76.6 wt.%) are strongly peraluminous (A/CNK = 1.1–1.6) and they have negative zircon ε<sub>Hf</sub>(t) values (−6.8 to −4.2, −12.8 to −6.1, respectively) and whole-rock ε<sub>Nd</sub>(t) values (−6.3 to −6.2, −8.4, respectively). These signatures indicate that the Damingshan and Yingqiao plutons were derived from partial melting of ancient metasedimentary rocks. Combining our data with those from previous studies on the magmatic, sedimentary and metamorphic records of this area, we suggest that the early Paleozoic magmatism is likely associated with lithospheric delamination and the Wuyi-Yunkai orogen is an intracontinental orogen linked to the far-field response to the assembly of the South China block with the Gondwana in the early Paleozoic.
DOI: 10.6084/m9.figshare.21088822
title: Additional supporting files.zip

description: Our research aims to identify CRT as a potential drug candidate for MN, and revealed that the treatment of CRT may effectively ameliorate renal dysfunction and reduce the podocyte injury via targeting the TNF-α-IL-6-JAK2/STAT3-MMP9 signaling axis, which may facilitate its clinical application in MN therapy. This dataset stores all the original data in this study.
DOI: 10.25403/upresearchdata.25187747.v1
title: Q-methodology and stated preferences data of stakeholder preferences for ecosystem services

description: The Q methodology study had data collected from 72 representative stakeholders who sorted 40 statements describing ESS into a predefined distribution. After introducing the research objectives, participants were asked to read statements presented on the 40 cards carefully, and then sort the cards into three stacks reflecting how they rank the statements as “important”, “neutral”, or “not important”. Then participants were requested to rank order the three stacks into the Q-board slots, which was 11-point quasi-normal (forced-choice) distribution on a Q-board ranging from −5 (not important at all) to +5 (extremely important). The by-person factor analysis was used to analyse the data.In the stated preferences study, choice data was collected from 450 respondents using face to face interviews. We then used a discrete choice experiment to elicit preferences for cultural and provisioning services.<br>
DOI: 10.6084/m9.figshare.7981934
title: Female-biased froghoppers (Hemiptera, Cercopoidea) from the Mesozoic of China and phylogenetic reconstruction of early Cercopoidea

description: Cercopoidea is a diverse insect group, but its early evolution, disparity and ecology remain unclear. <i>Juroala daohugouensis</i> Chen & Wang gen. et sp. nov., from the Middle–Upper Jurassic of north-eastern China, is established herein and described on the basis of 42 whole-bodied fossils, representing a new subfamily, Juroalinae subfam. nov. of the primitive family Sinoalidae. <i>Chengdecercopis</i> Hong, 1983 is transferred from Procercopidae to this new subfamily and <i>Stictocercopis</i> Fu & Huang, 2018 is also attributed to the new subfamily. Fangyuanini Chen & Wang trib. nov. is erected for <i>Fangyuania</i> Chen, Szwedo & Wang, 2018 from mid-Cretaceous Burmese amber. Our cladistic analyses recover the relationships within the Cercopoidea as follows: (Juroalinae + (Sinoalini + Fangyuanini)) + (Procercopidae + (Cercopionidae + five modern families)). The evolutionary history and morphological diversification in the Mesozoic is discussed based on our phylogenetic reconstruction. In addition, the abundant material in the present study not only indicates high intra-specific or even intra-individual variation caused by biological and/or taphonomic factors, but also reveals an extremely female-biased propensity, suggesting that the new taxon probably had adaptations to special palaeoenvironments in physiology, ecology and ethology (e.g. parthenogenesis and sociability). http://zoobank.org/urn:lsid:zoobank.org:pub:5EDD7D33-D509-4330-A01F-F41DF664E1C2
DOI: 10.6084/m9.figshare.7981934.v1
title: Female-biased froghoppers (Hemiptera, Cercopoidea) from the Mesozoic of China and phylogenetic reconstruction of early Cercopoidea

description: Cercopoidea is a diverse insect group, but its early evolution, disparity and ecology remain unclear. <i>Juroala daohugouensis</i> Chen & Wang gen. et sp. nov., from the Middle–Upper Jurassic of north-eastern China, is established herein and described on the basis of 42 whole-bodied fossils, representing a new subfamily, Juroalinae subfam. nov. of the primitive family Sinoalidae. <i>Chengdecercopis</i> Hong, 1983 is transferred from Procercopidae to this new subfamily and <i>Stictocercopis</i> Fu & Huang, 2018 is also attributed to the new subfamily. Fangyuanini Chen & Wang trib. nov. is erected for <i>Fangyuania</i> Chen, Szwedo & Wang, 2018 from mid-Cretaceous Burmese amber. Our cladistic analyses recover the relationships within the Cercopoidea as follows: (Juroalinae + (Sinoalini + Fangyuanini)) + (Procercopidae + (Cercopionidae + five modern families)). The evolutionary history and morphological diversification in the Mesozoic is discussed based on our phylogenetic reconstruction. In addition, the abundant material in the present study not only indicates high intra-specific or even intra-individual variation caused by biological and/or taphonomic factors, but also reveals an extremely female-biased propensity, suggesting that the new taxon probably had adaptations to special palaeoenvironments in physiology, ecology and ethology (e.g. parthenogenesis and sociability). http://zoobank.org/urn:lsid:zoobank.org:pub:5EDD7D33-D509-4330-A01F-F41DF664E1C2
DOI: 10.25378/janelia.13749154.v1
title: EASI-FISH enabled spatial analysis of molecular cell types in the lateral hypothalamus

description: Expansion-Assisted Iterative Fluorescence in situ hybridization (EASI-FISH) allows spatial analysis of molecular cell types in thick tissue volumes (300µm). We applied EASI-FISH to the mouse lateral hypothalamus (LHA), a brain region that has been studied for decades as an important motivational center regulating ingestive, social, arousal, and autonomic functions. Despite extensive functional investigation, the understanding of the LHA is limited by poor anatomical definition. Here, we performed EASI-FISH using 24 molecular cell type markers identified from scRNA-Seq and uncovered an unexpected parcellation of the LHA not previously described from cell density measurements. It also reveals morphological diversity of neuronal types in this region. 'EASI_FISH_gene_count.csv' contains spot count per cell for all marker genes probed. Marker genes, <i>Meis2</i> and <i>Th </i>were probed twice (R1 and R9) to evaluate the RNA stability of the samples. Columns are marker genes and rows are neuron IDs. Data collected from three animals (LHA1, LHA2 and LHA3).<br><br>'EASI_FISH_metadata.csv' contains metadata for each neuron. Rows are neuron IDs and columns are metadata, including neuronal position (z, y, x, after rigid alignment), soma volume (area), soma shape (aspect ratio and solidity), molecular cell type it belongs to (cell type), etc. All measurements presented here in pre-expansion units.
DOI: 10.25378/janelia.13749154.v3
title: EASI-FISH enabled spatial analysis of molecular cell types in the lateral hypothalamus

description: Expansion-Assisted Iterative Fluorescence in situ hybridization (EASI-FISH) allows spatial analysis of molecular cell types in thick tissue volumes (300µm). We applied EASI-FISH to the mouse lateral hypothalamus (LHA), a brain region that has been studied for decades as an important motivational center regulating ingestive, social, arousal, and autonomic functions. Despite extensive functional investigation, the understanding of the LHA is limited by poor anatomical definition. Here, we performed EASI-FISH using 24 molecular cell type markers identified from scRNA-Seq and uncovered an unexpected parcellation of the LHA not previously described from cell density measurements. It also reveals morphological diversity of neuronal types in this region. 'EASI_FISH_gene_count.csv' contains spot count per cell for all marker genes probed. Marker genes, <i>Meis2</i> and <i>Th </i>were probed twice (R1 and R9) to evaluate the RNA stability of the samples. Columns are marker genes and rows are neuron IDs. Data collected from three animals (LHA1, LHA2 and LHA3).<br><br>'EASI_FISH_metadata.csv' contains metadata for each neuron. Rows are neuron IDs and columns are metadata, including neuronal position (z, y, x, after rigid alignment), soma volume (area), soma shape (eccentricity and solidity), molecular cell type it belongs to (cell type), etc. All measurements presented here in pre-expansion units.
DOI: 10.25378/janelia.13749154.v2
title: EASI-FISH enabled spatial analysis of molecular cell types in the lateral hypothalamus

description: Expansion-Assisted Iterative Fluorescence in situ hybridization (EASI-FISH) allows spatial analysis of molecular cell types in thick tissue volumes (300µm). We applied EASI-FISH to the mouse lateral hypothalamus (LHA), a brain region that has been studied for decades as an important motivational center regulating ingestive, social, arousal, and autonomic functions. Despite extensive functional investigation, the understanding of the LHA is limited by poor anatomical definition. Here, we performed EASI-FISH using 24 molecular cell type markers identified from scRNA-Seq and uncovered an unexpected parcellation of the LHA not previously described from cell density measurements. It also reveals morphological diversity of neuronal types in this region. 'EASI_FISH_gene_count.csv' contains spot count per cell for all marker genes probed. Marker genes, <i>Meis2</i> and <i>Th </i>were probed twice (R1 and R9) to evaluate the RNA stability of the samples. Columns are marker genes and rows are neuron IDs. Data collected from three animals (LHA1, LHA2 and LHA3).<br><br>'EASI_FISH_metadata.csv' contains metadata for each neuron. Rows are neuron IDs and columns are metadata, including neuronal position (z, y, x, after rigid alignment), soma volume (area), soma shape (aspect ratio and solidity), molecular cell type it belongs to (cell type), etc. All measurements presented here in pre-expansion units.
DOI: 10.6084/m9.figshare.13219314
title: Additional file 10 of Integrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells

description: Additional file 10. KEGG of trans-target genes.
DOI: 10.6084/m9.figshare.13219335
title: Additional file 6 of Integrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells

description: Additional file 6. DE-lncRNA and their trans-target genes.
DOI: 10.6084/m9.figshare.22662136
title: Characterizing accumulation of aerosol particles on leaves of urban trees and their negative effects

description:  data for Figure 1, Figure 3, Figure 5, Figure6, Figure 7 and Figure 8
DOI: 10.6084/m9.figshare.13219338.v1
title: Additional file 7 of Integrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells

description: Additional file 7. GO terms, biological processes, cellular components and molecular function of cis-target genes.
DOI: 10.6084/m9.figshare.13219314.v1
title: Additional file 10 of Integrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells

description: Additional file 10. KEGG of trans-target genes.