cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4743499
title: Geometrical uncertainty of heart position in deep-inspiration breath-hold radiotherapy of left-sided breast cancer patients

description: <b>Background:</b> This study aimed to determine the geometrical uncertainty of the position of the heart with daily cone beam computed tomography (CBCT) during deep-inspiration breath-hold (DIBH) treatment of the left breast. <b>Material and methods:</b> A visually guided optical respiratory monitoring system was used in DIBH treatment of 15 breast cancer patients. Heart position was determined in relation to the planning target volume (PTV) in 225 fractions in which daily low-dose CBCT images were compared with planning CT images. In addition, the position of the left lung apex and diaphragm was measured to evaluate the success of the DIBH. <b>Results:</b> The median shift of the heart was 1 mm to the left, 1 mm superiorly and 0 mm in the anterior–posterior (AP) direction during the treatment course when compared to the PTV position in planning CT. Based on these movements, an AP margin of 4 mm, a lateral (LR) margin of 3 mm, and a superior–inferior (SI) margin of 5 mm should be added to the heart contour to ensure avoiding the heart when planning treatment. The distance between the left lung apex and diaphragm, applied as a surrogate for lung volume, was 2mm (median) smaller during the CBCT acquisitions than during the planning CT acquisition. The correlation coefficient between the surrogate of lung volume and the distance between the heart and PTV was <i>r</i> = .46 in the AP, <i>r</i> = .72 in the LR and <i>r</i> = .79 in the SI directions. <b>Conclusion:</b> Residual variation was observed in the position of the heart in comparison to PTV, even with a visually guided DIBH technique. These geometrical uncertainties should be taken into account when planning radiotherapy treatment. The success of DIBH may make a major contribution to the variation of the heart position during treatment.
DOI: 10.6084/m9.figshare.4743499.v1
title: Geometrical uncertainty of heart position in deep-inspiration breath-hold radiotherapy of left-sided breast cancer patients

description: <b>Background:</b> This study aimed to determine the geometrical uncertainty of the position of the heart with daily cone beam computed tomography (CBCT) during deep-inspiration breath-hold (DIBH) treatment of the left breast. <b>Material and methods:</b> A visually guided optical respiratory monitoring system was used in DIBH treatment of 15 breast cancer patients. Heart position was determined in relation to the planning target volume (PTV) in 225 fractions in which daily low-dose CBCT images were compared with planning CT images. In addition, the position of the left lung apex and diaphragm was measured to evaluate the success of the DIBH. <b>Results:</b> The median shift of the heart was 1 mm to the left, 1 mm superiorly and 0 mm in the anterior–posterior (AP) direction during the treatment course when compared to the PTV position in planning CT. Based on these movements, an AP margin of 4 mm, a lateral (LR) margin of 3 mm, and a superior–inferior (SI) margin of 5 mm should be added to the heart contour to ensure avoiding the heart when planning treatment. The distance between the left lung apex and diaphragm, applied as a surrogate for lung volume, was 2mm (median) smaller during the CBCT acquisitions than during the planning CT acquisition. The correlation coefficient between the surrogate of lung volume and the distance between the heart and PTV was <i>r</i> = .46 in the AP, <i>r</i> = .72 in the LR and <i>r</i> = .79 in the SI directions. <b>Conclusion:</b> Residual variation was observed in the position of the heart in comparison to PTV, even with a visually guided DIBH technique. These geometrical uncertainties should be taken into account when planning radiotherapy treatment. The success of DIBH may make a major contribution to the variation of the heart position during treatment.
DOI: 10.6084/m9.figshare.4743268
title: Competency milestones for medical students: Design, implementation, and analysis at one medical school

description: Competency-based assessment seeks to align measures of performance directly with desired learning outcomes based upon the needs of patients and the healthcare system. Recognizing that assessment methods profoundly influence student motivation and effort, it is critical to measure all desired aspects of performance throughout an individual’s medical training. The Accreditation Council for Graduate Medical Education (ACGME) defined domains of competency for residency; the subsequent Milestones Project seeks to describe each learner’s progress toward competence within each domain. Because the various clinical disciplines defined unique competencies and milestones within each domain, it is difficult for undergraduate medical education to adopt existing GME milestones language. This paper outlines the process undertaken by one medical school to design, implement and improve competency milestones for medical students. A team of assessment experts developed milestones for a set of focus competencies; these have now been monitored in medical students over two years. A unique digital dashboard enables individual, aggregate and longitudinal views of student progress by domain. Validation and continuous quality improvement cycles are based upon expert review, user feedback, and analysis of variation between students and between assessors. Experience to date indicates that milestone-based assessment has significant potential to guide the development of medical students.
DOI: 10.6084/m9.figshare.4743268.v1
title: Competency milestones for medical students: Design, implementation, and analysis at one medical school

description: Competency-based assessment seeks to align measures of performance directly with desired learning outcomes based upon the needs of patients and the healthcare system. Recognizing that assessment methods profoundly influence student motivation and effort, it is critical to measure all desired aspects of performance throughout an individual’s medical training. The Accreditation Council for Graduate Medical Education (ACGME) defined domains of competency for residency; the subsequent Milestones Project seeks to describe each learner’s progress toward competence within each domain. Because the various clinical disciplines defined unique competencies and milestones within each domain, it is difficult for undergraduate medical education to adopt existing GME milestones language. This paper outlines the process undertaken by one medical school to design, implement and improve competency milestones for medical students. A team of assessment experts developed milestones for a set of focus competencies; these have now been monitored in medical students over two years. A unique digital dashboard enables individual, aggregate and longitudinal views of student progress by domain. Validation and continuous quality improvement cycles are based upon expert review, user feedback, and analysis of variation between students and between assessors. Experience to date indicates that milestone-based assessment has significant potential to guide the development of medical students.
DOI: 10.6084/m9.figshare.4743061
title: Integrated control of wood destroying basidiomycetes.xlsx

description: Integrated control of wood destroying basidiomycetes<br>
DOI: 10.6084/m9.figshare.4743022
title: Supplementary Material for: The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics

description: Neurodegenerative diseases include a significant number of pathologies affecting the nervous system. Generally, the primary cause of each disease is specific; however, recently, it was shown that they may be correlated at molecular level. This aspect, together with the exhibition of similar symptoms, renders the diagnosis of these disorders difficult. Amyotrophic lateral sclerosis is one of these pathologies. Herein, we report several cases of amyotrophic lateral sclerosis misdiagnosed as a consequence of features that are common to several neurodegenerative diseases, such as Parkinson's, Huntington's and Alzheimer's disease, spinal muscular atrophy, progressive bulbar palsy, spastic paraplegia and frontotemporal dementia, and mostly with the lysosomal storage disorder GM2 gangliosidosis. Overall reports highlight that the differential diagnosis for amyotrophic lateral sclerosis should include correlated mechanisms.
DOI: 10.6084/m9.figshare.4743028
title: Supplementary Material for Procognitive Compounds Promote Neurite Outgrowth

description: <strong><em>Background/Aims:</em></strong> To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense investigations to develop disease-modifying drugs to suppress progressive neurodegeneration. <b><i>Methods:</i></b> In this study, a range of procognitive compounds are tested in a primary neuronal culture to determine their relative potential for promoting neuritogenesis. <b><i>Results:</i></b> We report that donepezil, memantine, dimebon, Pre-084 and 4-IBP are neuritogenic while tacrine, rosemarinic acid, memoquin and a BACE1 inhibitor suppress neurite outgrowth of neurons. <b><i>Conclusions:</i></b> The results of this study indicate that some procognitive compounds may possess a disease-modifying potential.
DOI: 10.6084/m9.figshare.4743061.v1
title: Determination of toxic values.xlsx

description: Integrated control of wood destroying basidiomycetes<br>
DOI: 10.6084/m9.figshare.4743022.v1
title: Supplementary Material for: The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics

description: Neurodegenerative diseases include a significant number of pathologies affecting the nervous system. Generally, the primary cause of each disease is specific; however, recently, it was shown that they may be correlated at molecular level. This aspect, together with the exhibition of similar symptoms, renders the diagnosis of these disorders difficult. Amyotrophic lateral sclerosis is one of these pathologies. Herein, we report several cases of amyotrophic lateral sclerosis misdiagnosed as a consequence of features that are common to several neurodegenerative diseases, such as Parkinson's, Huntington's and Alzheimer's disease, spinal muscular atrophy, progressive bulbar palsy, spastic paraplegia and frontotemporal dementia, and mostly with the lysosomal storage disorder GM2 gangliosidosis. Overall reports highlight that the differential diagnosis for amyotrophic lateral sclerosis should include correlated mechanisms.
DOI: 10.6084/m9.figshare.4743028.v1
title: Supplementary Material for Procognitive Compounds Promote Neurite Outgrowth

description: <strong><em>Background/Aims:</em></strong> To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense investigations to develop disease-modifying drugs to suppress progressive neurodegeneration. <b><i>Methods:</i></b> In this study, a range of procognitive compounds are tested in a primary neuronal culture to determine their relative potential for promoting neuritogenesis. <b><i>Results:</i></b> We report that donepezil, memantine, dimebon, Pre-084 and 4-IBP are neuritogenic while tacrine, rosemarinic acid, memoquin and a BACE1 inhibitor suppress neurite outgrowth of neurons. <b><i>Conclusions:</i></b> The results of this study indicate that some procognitive compounds may possess a disease-modifying potential.
DOI: 10.6084/m9.figshare.4742980
title: Supplementary Material for: An Intron 9 CYP19 Gene Variant (IVS9+5G&gt;A), Present in an Aromatase-Deficient Girl, Affects Normal Splicing and Is Also Present in Normal Human Steroidogenic Tissues

description: <strong><em>Background/Aims:</em></strong> Splicing CYP19 gene variants causing aromatase deficiency in 46,XX disorder of sexual development (DSD) patients have been reported in a few cases. A misbalance between normal and aberrant splicing variants was proposed to explain spontaneous pubertal breast development but an incomplete sex maturation progress. The aim of this study was to functionally characterize a novel <i>CYP19A1</i> intronic homozygote mutation (IVS9+5G&gt;A) in a 46,XX DSD girl presenting spontaneous breast development and primary amenorrhea, and to evaluate similar splicing variant expression in normal steroidogenic tissues. <b><i>Methods:</i></b> Genomic DNA analysis, splicing prediction programs, splicing assays, and in vitro protein expression and enzyme activity analyses were carried out. <i>CYP19A1 </i>mRNA expression in human steroidogenic tissues was also studied. <b><i>Results:</i></b> A novel IVS9+5G&gt;A homozygote mutation was found. In silico analysis predicts the disappearance of the splicing donor site in intron 9, confirmed by patient peripheral leukocyte cP450arom and in vitro studies. Protein analysis showed a shorter and inactive protein. The intron 9 transcript variant was also found in human steroidogenic tissues. <b><i>Conclusions:</i></b> The mutation IVS9+5G&gt;A generates a splicing variant that includes intron 9 which is also present in normal human steroidogenic tissues, suggesting that a misbalance between normal and aberrant splicing variants might occur in target tissues, explaining the clinical phenotype in the affected patient.
DOI: 10.6084/m9.figshare.4742980.v1
title: Supplementary Material for: An Intron 9 CYP19 Gene Variant (IVS9+5G&gt;A), Present in an Aromatase-Deficient Girl, Affects Normal Splicing and Is Also Present in Normal Human Steroidogenic Tissues

description: <strong><em>Background/Aims:</em></strong> Splicing CYP19 gene variants causing aromatase deficiency in 46,XX disorder of sexual development (DSD) patients have been reported in a few cases. A misbalance between normal and aberrant splicing variants was proposed to explain spontaneous pubertal breast development but an incomplete sex maturation progress. The aim of this study was to functionally characterize a novel <i>CYP19A1</i> intronic homozygote mutation (IVS9+5G&gt;A) in a 46,XX DSD girl presenting spontaneous breast development and primary amenorrhea, and to evaluate similar splicing variant expression in normal steroidogenic tissues. <b><i>Methods:</i></b> Genomic DNA analysis, splicing prediction programs, splicing assays, and in vitro protein expression and enzyme activity analyses were carried out. <i>CYP19A1 </i>mRNA expression in human steroidogenic tissues was also studied. <b><i>Results:</i></b> A novel IVS9+5G&gt;A homozygote mutation was found. In silico analysis predicts the disappearance of the splicing donor site in intron 9, confirmed by patient peripheral leukocyte cP450arom and in vitro studies. Protein analysis showed a shorter and inactive protein. The intron 9 transcript variant was also found in human steroidogenic tissues. <b><i>Conclusions:</i></b> The mutation IVS9+5G&gt;A generates a splicing variant that includes intron 9 which is also present in normal human steroidogenic tissues, suggesting that a misbalance between normal and aberrant splicing variants might occur in target tissues, explaining the clinical phenotype in the affected patient.
DOI: 10.6084/m9.figshare.4742968
title: Supplementary Material for: Are All Oscillators Created Equal? In vitro Performance Characteristics of Eight High-Frequency Oscillatory Ventilators

description: <strong><em>Background:</em></strong> The mode of waveform generation and circuit characteristics differ between high-frequency oscillators. It is unknown if this influences performance. <b><i>Objectives:</i></b> To describe the relationships between set and delivered pressure amplitude (ΔP), and the interaction with frequency and endotracheal tube (ETT) diameter, in eight high-frequency oscillators. <b><i>Methods:</i></b> Oscillators were evaluated using a 70-ml test lung at 1.0 and 2.0 ml/cm H<sub>2</sub>O compliance, with mean airway pressures (P<sub>AW</sub>) of 10 and 20 cm H<sub>2</sub>O, frequencies of 5, 10 and 15 Hz, and an ETT diameter of 2.5 and 3.5 mm. At each permutation of P<sub>AW</sub>, frequency and ETT, the set ΔP was sequentially increased from 15 to 50 cm H<sub>2</sub>O, or from 20 to 100% maximum amplitude (10% increments) depending on the oscillator design. The ΔP at the ventilator (ΔP<sub>VENT</sub>), airway opening (ΔP<sub>AO</sub>) and within the test lung (ΔP<sub>TRACH</sub>), and tidal volume (V<sub>T</sub>) at the airway opening were determined at each set ΔP. <b><i>Results:</i></b> In two oscillators the relationships between set and delivered ΔP were non-linear, with a plateau in ΔP thresholds noted at all frequencies (Dräger Babylog 8000) or ≥10 Hz (Dräger VN500). In all other devices there was a linear relationship between ΔP<sub>VENT</sub>, ΔP<sub>AO</sub> and ΔP<sub>TRACH</sub> (all r<sup>2</sup> &gt;0.93), with differing attenuation of the pressure wave. Delivered V<sub>T</sub> at the different settings tested varied between devices, with some unable to deliver V<sub>T</sub> &gt;3 ml at 15 Hz, and others generating V<sub>T</sub> &gt;20 ml at 5 Hz and a 1:1 inspiratory-to-expiratory time ratio. <b><i>Conclusions:</i></b> Clinicians should be aware that modern high-frequency oscillators exhibit important differences in the delivered ΔP and V<sub>T</sub>.
DOI: 10.6084/m9.figshare.4742968.v1
title: Supplementary Material for: Are All Oscillators Created Equal? In vitro Performance Characteristics of Eight High-Frequency Oscillatory Ventilators

description: <strong><em>Background:</em></strong> The mode of waveform generation and circuit characteristics differ between high-frequency oscillators. It is unknown if this influences performance. <b><i>Objectives:</i></b> To describe the relationships between set and delivered pressure amplitude (ΔP), and the interaction with frequency and endotracheal tube (ETT) diameter, in eight high-frequency oscillators. <b><i>Methods:</i></b> Oscillators were evaluated using a 70-ml test lung at 1.0 and 2.0 ml/cm H<sub>2</sub>O compliance, with mean airway pressures (P<sub>AW</sub>) of 10 and 20 cm H<sub>2</sub>O, frequencies of 5, 10 and 15 Hz, and an ETT diameter of 2.5 and 3.5 mm. At each permutation of P<sub>AW</sub>, frequency and ETT, the set ΔP was sequentially increased from 15 to 50 cm H<sub>2</sub>O, or from 20 to 100% maximum amplitude (10% increments) depending on the oscillator design. The ΔP at the ventilator (ΔP<sub>VENT</sub>), airway opening (ΔP<sub>AO</sub>) and within the test lung (ΔP<sub>TRACH</sub>), and tidal volume (V<sub>T</sub>) at the airway opening were determined at each set ΔP. <b><i>Results:</i></b> In two oscillators the relationships between set and delivered ΔP were non-linear, with a plateau in ΔP thresholds noted at all frequencies (Dräger Babylog 8000) or ≥10 Hz (Dräger VN500). In all other devices there was a linear relationship between ΔP<sub>VENT</sub>, ΔP<sub>AO</sub> and ΔP<sub>TRACH</sub> (all r<sup>2</sup> &gt;0.93), with differing attenuation of the pressure wave. Delivered V<sub>T</sub> at the different settings tested varied between devices, with some unable to deliver V<sub>T</sub> &gt;3 ml at 15 Hz, and others generating V<sub>T</sub> &gt;20 ml at 5 Hz and a 1:1 inspiratory-to-expiratory time ratio. <b><i>Conclusions:</i></b> Clinicians should be aware that modern high-frequency oscillators exhibit important differences in the delivered ΔP and V<sub>T</sub>.
DOI: 10.6084/m9.figshare.4742944
title: stuy1&2.sav

description: raw data study 1 regarding plos one publication entitled 'The (non-)replicability of regulatory resource depletion: A field report employing non-invasive brain stimulation'
DOI: 10.6084/m9.figshare.4742944.v1
title: stuy1.sav

description: raw data study 1 regarding plos one publication entitled 'The (non-)replicability of regulatory resource depletion: A field report employing non-invasive brain stimulation'
DOI: 10.6084/m9.figshare.4742887
title: Supplementary Material for: Men's Views on Depression: A Systematic Review and Metasynthesis of Qualitative Research

description: <b><i>Background:</i></b> According to the concept of “male depression,” depression among men might be underdiagnosed and undertreated because of gender differences in symptoms and coping. There is evidence that men experience atypical depressive symptoms including irritability, aggression, substance abuse, and increased risk behavior. To date, a substantial number of qualitative studies on men's views on depression has been conducted in the last few decades. <b><i>Methods:</i></b> Based on a systematic review and metasynthesis of qualitative studies on men's subjective perspectives on depression, we aim at a comprehensive understanding of men's subjective views on depression with a specific focus on masculinity constructions. <b><i>Results:</i></b> Based on 34 studies assessed as appropriate for the study, 2 overarching subthemes could be identified: normative expectations regarding masculinity ideals and men's subjective perspectives of depression as “weakness.” Men's strategies include denial of “weakness” and “closing up.” Further themes include suicide, masculinity ideals as a healthy resource, and alternative masculinities. <b><i>Discussion/Conclusions:</i></b> Traditional masculinity values might serve as barriers but also as facilitators to adaptive coping strategies in depressed men. More research is needed to study the dimensions and role of alternative masculinities in the context of depression.
DOI: 10.6084/m9.figshare.4742878
title: Supplementary Material for: Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function

description: <b><i>Background:</i></b> While elevated serum uric acid level (SUA) is a recognized risk factor for chronic kidney disease, it remains unclear whether change in SUA is independently associated with change in estimated glomerular filtration rate (eGFR) over time. Accordingly, we examined the longitudinal associations between change in SUA and change in eGFR over 5 years in a general Japanese population. <b><i>Methods:</i></b> This was a large, single-center, retrospective 5-year cohort study at St. Luke's International Hospital, Tokyo, Japan, between 2004 and 2009. We included 13,070 subjects (30-85 years) in our analyses whose data were available between 2004 and 2009. Of those, we excluded 492 subjects with eGFR &lt;60 mL/min/1.73 m<sup>2</sup> at baseline. In addition to examining the entire cohort (<i>n</i> = 12,578), we stratified our analyses by baseline eGFR groups: 60-90, 90-120, and ≥120 mL/min/1.73 m<sup>2</sup>. Linear and logistic regressions models were applied to examine the relationships between baseline and change in SUA, change in eGFR, and rapid eGFR decline (defined as the highest quartile of change in eGFR), adjusted for age, gender, body mass index, abdominal circumference, hypertension, dyslipidemia, and diabetes mellitus. <b><i>Results:</i></b> After multivariable adjustments including baseline eGFR, 1 mg/dL increase in baseline SUA was associated with greater odds of developing rapid eGFR decline (OR 1.27, 95% CI 1.17-1.38), and 1 mg/dL increase in SUA over 5 years was associated with 3.77-fold greater odds of rapid eGFR decline (OR 3.77, 95% CI 3.35-4.26). <b><i>Conclusions:</i></b> Elevated baseline SUA and increasing SUA over time were independent risk factors for rapid eGFR decline over 5 years.