cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5061/dryad.d4485db
title: Data from: Functional differences of BaPDS1 and BaPDS2 genes in Chinese kale

description: This study presents a systematic analysis of the functional differences
 between two genes that encode phytoene desaturase (PDS) in Chinese kale.
 The promoter sequences of both BaPDS1 and BaPDS2 were amplified and
 cloned, and their lengths were 2005 bp and 2000 bp, respectively. Mining
 of cis-acting elements in the promoters showed that the two BaPDS genes
 are mainly associated with light and phytohormone responsiveness. Light
 quality, light intensity, and plant hormone treatments were conducted in
 seedlings of Chinese kale, and the results indicated that the response of
 the two genes to different factors differed. Among them, BaPDSs
 collectively respond to the treatment with salicylic acid and abscisic
 acid. With regard to response differences, BaPDS1 is sensitive to red and
 blue light, blue light, and strong light, while BaPDS2 responds to blue
 light, weak light, darkness, gibberellin, and methyl jasmonate. In
 addition, both BaPDS1 and BaPDS2 are likely targeted to could both be
 targeted to the chloroplast. Furthermore, single and double mutants of
 BaPDSs were generated via CRISPR/Cas9 technology. Phenotypic analysis
 showed that the double mutant with edited PDS1 and PDS2 was a pure albino,
 while the single mutants with edited PDS1 or PDS2 were partly whitened. In
 summary, BaPDS1 and BaPDS2 genes played different and indispensable roles
 in Chinese kale, and their functions were partially complementary.
description: RSOS-190260--Raw
 DataTable 1 Gene expression
 levels of BaPDS1 and BaPDS2 under light and phytohormone
 treatmentsRSOS-19--Raw
 Data.xlsx
DOI: 10.5061/dryad.4c80mn5
title: Data from: Distinct roles of striatal direct and indirect pathways in value-based decision making

description: The striatum is critically involved in value-based decision making.
 However, it is unclear how striatal direct and indirect pathways work
 together to make optimal choices in a dynamic and uncertain environment.
 Here, we examined the effects of selectively inactivating D1 receptor
 (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons
 (corresponding to direct- and indirect-pathway neurons, respectively) on
 mouse choice behavior in a reversal task with progressively increasing
 reversal frequency and a dynamic two-armed bandit task. Inactivation of
 either D1R- or D2R-expressing striatal neurons impaired performance in
 both tasks, but the pattern of altered choice behavior differed between
 the two animal groups. A reinforcement learning model-based analysis
 indicated that inactivation of D1R- and D2R-expressing striatal neurons
 selectively impairs value-dependent action selection and value learning,
 respectively. Our results suggest differential contributions of striatal
 direct and indirect pathways to two distinct steps in value-based decision
 making.
description: data_all
DOI: 10.5061/dryad.bd4486s
title: Data from: Low-latitude zooplankton pigmentation plasticity in response to multiple threats

description: Crustacean copepods in high-latitude lakes frequently alter their
 pigmentation facultatively to defend themselves against prevailing
 threats, such as solar ultraviolet radiation (UVR) and visually-oriented
 predators. Strong seasonality in those environments promotes phenotypic
 plasticity. To date, no one has investigated whether low-latitude
 copepods, experiencing continuous stress from UVR and predation threats,
 exhibit similar inducible defences. We here investigated the pigmentation
 levels of Bahamian ‘blue hole’ copepods, addressing this deficit.
 Examining several populations varying in predation risk, we found the
 lowest levels of pigmentation in the population experiencing the highest
 predation pressure. In a laboratory experiment, we found that, in contrast
 to our predictions, copepods from these relatively constant environments
 did show some changes in pigmentation subsequent to removal of UVR;
 however, exposure to water from different predation regimes induced minor
 and idiosyncratic pigmentation changes. Our findings suggest low-latitude
 zooplankton in inland environments may exhibit reduced, but non-zero,
 levels of phenotypic plasticity compared to their high-latitude
 counterparts.
description: Data files and
 scriptData files required to
 run analyses and produce figures. Script includedPhotosPhotos of copepods from
 various blue holes on Andros Island. Pigmentation information was
 extracted from these photos.Turbidity
 dataRaw data and the script
 to determine how similar the UV threat will be across the three selected
 blue holes.Turbidity.zip
DOI: 10.5061/dryad.98bb788
title: Data from: Smooth muscle regional contribution to vaginal wall function

description: Pelvic organ prolapse is characterized as the descent of the pelvic organs
 into the vaginal canal. In the USA, there is a 12% lifetime risk for
 requiring surgical intervention. Although vaginal childbirth is a
 well-established risk factor for prolapse, the underlying mechanisms are
 not fully understood. Decreased smooth muscle organization, composition
 and maximum muscle tone are characteristics of prolapsed vaginal tissue.
 Maximum muscle tone of the vaginal wall was previously investigated in the
 circumferential or axial direction under uniaxial loading; however, the
 vaginal wall is subjected to multiaxial loads. Further, the contribution
 of vaginal smooth muscle basal (resting) tone to mechanical function
 remains undetermined. The objectives of this study were to determine the
 contribution of smooth muscle basal and maximum tone to the regional
 biaxial mechanical behaviour of the murine vagina. Vaginal tissue from
 C57BL/6 mice was subjected to extension–inflation protocols (n = 10) with
 and without basal smooth muscle tone. Maximum tone was induced with KCl
 under various circumferential (n = 5) and axial (n = 5) loading
 conditions. The microstructure was visualized with multiphoton microscopy
 (n = 1), multiaxial histology (n = 4) and multiaxial immunohistochemistry
 (n = 4). Smooth muscle basal tone decreased material stiffness and
 increased anisotropy. In addition, maximum vaginal tone was decreased with
 increasing intraluminal pressures. This study demonstrated that vaginal
 muscle tone contributed to the biaxial mechanical response of murine
 vaginal tissue. This may be important in further elucidating the
 underlying mechanisms of prolapse, in order to improve current
 preventative and treatment strategies.
description: Biaxial Mechanical Test
 DataExperimental data from
 pressure-diameter and force-length test. Pressure, diameter, axial force,
 and length data combined for eight loading protocols. The unloaded
 dimensions (outer diameter, thickness, and length) for each vaginal tissue
 are provided for the proximal and distal region.Biaxial Contractility
 DataExperimental data from
 biaxial contractile test under isobaric-axially isometric protocols.
 Pressure, diameter, axial force, and length data for each loading
 protocols. The relaxed or passive, unloaded dimensions (outer diameter,
 thickness, and length) for each vaginal tissue are provided for the
 proximal and distal regions.
DOI: 10.7488/ds/8071
title: Comparison of human metapneumovirus and respiratory syncytial virus-associated health burden in adults living with chronic underlying health conditions: a systematic review and meta-analysis

description: Background: We aimed to systematically compare the health burden associated with hMPV and RSV respiratory tract infections in adults with chronic illnesses. Methods: We searched MEDLINE, EMBASE, Global Health, CINAHL, Web of Science, and Global Index Medicus on 18/08/2025 and 12/01/2026. We included observational and interventional studies conducted from 2001 onwards, reporting laboratory-confirmed hMPV and RSV infections in adults with chronic illnesses. Quality assessment was conducted using the Joanna Briggs Institute critical appraisal tools. We developed an overall estimate, using a generalised linear mixed-effects model with a binomial distribution and logit link, including a study-level random intercept and fixed effects for virus, setting, and their interaction. Predicted probabilities and population-average odds ratios (OR) comparing RSV and hMPV were calculated. Incidence and disease severity outcomes were synthesised narratively due to heterogeneous and limited data. The protocol was registered on Open Science Framework [doi:10.17605/OSF.IO/EPB3X]. Results: Fifty studies were included, reporting on hMPV and RSV test positivity (n=44; 29,603 laboratory tests), incidence (n=3), and disease severity outcomes (n=7). The OR of RSV test positivity versus hMPV in adults with at least one chronic illness was 1.88 (95% CI: 1.61–2.19) in inpatient settings and 1.65 (1.43–1.91) across all settings in studies relying on annual data. Significant differences in RSV versus hMPV test positivity were found for chronic respiratory disease (annual and seasonal analyses), cardiovascular (seasonal), immunocompromised (annual), and haematologic (annual) conditions, but not among solid organ transplant recipients (annual). Incidence and severity data demonstrated inconsistent patterns. Conclusions: RSV occurs more frequently than hMPV in adults living with chronic illnesses. However, evidence gaps remain regarding comparative disease severity and data from low- and middle-income countries. Funding: AstraZeneca plc.
DOI: 10.5061/dryad.9hb966d
title: Data from: A population genomics insight by 2b-RAD reveals populations’ uniqueness along the Italian coastline in Leptopsammia pruvoti (Scleractinia, Dendrophylliidae).

description: Aim: Marine bioconstructions such as coralligenous formations are hot spot
 of biodiversity and play a relevant ecological role in the preservation of
 biodiversity by providing carbon regulation, protection and nursery areas
 for several marine species. For this reason, the European Union Habitat
 Directive included them among priority habitats to be preserved. Despite
 their ecological role is well-established, connectivity patterns are still
 poorly investigated, representing a limit in conservation planning. The
 present study pioneers a novel approach for the analysis of connectivity
 in marine bioconstructor species, which often lack suitable genetic
 markers, by taking advantage of next generation sequencing techniques. We
 assess the geographical patterns of genomic variation of the sunset cup
 coral Leptopsammia pruvoti Lacaze-Duthiers, 1897, an ahermatypic,
 non-zooxanthellate and solitary scleractinian coral species common in
 coralligenous habitats and distributed across the Mediterranean Sea.
 Location: The Italian coastline (Western and Central Mediterranean).
 Methods: We applied the restriction site associated 2b-RAD approach to
 genotype over 1,000 high quality and filtered Single Nucleotide
 Polymorphisms in 10 population samples. Results: The results revealed the
 existence of a strongly supported genetic structure, with highly
 significant pairwise FST values between all the population samples,
 including those collected about 5 kilometers apart from each other.
 Moreover, genomic data indicates that the strongest barriers to gene flow
 are between the western (Ligurian-Tyrrhenian Sea) and the eastern side
 (Adriatic Sea) of the Italian peninsula. Main conclusions: The strong
 differentiation found in L. pruvoti, is similar to that found in other
 species of marine bioconstructors investigated in this area, but it
 strongly contrasts with the small differences found in many fish and
 invertebrates at the same geographic scale. All in one, our results
 highlight the importance of assessing connectivity in species belonging to
 coralligenous habitats as, due to their limited dispersal ability, they
 might require specific spatial conservation measures.
description: 212samples_1386markers_genepopText file (genepop input format) containing the genotypes used for population genomics analysis. The file contains the genotypes of 1386 SNPs typed in 212 individuals, from 10 population samples. The population order is TGN (Tegnùe, Chioggia), TR (Tremiti islands), OT (Otranto), TP (Trapani), CSP (Capo Spartivento), TAV (Tavolara), GNS (Giannutri South), GNN (Giannutri North), PTF (Portofino) and GA (Gallinara).
DOI: 10.5061/dryad.1rd4hc7
title: Data from: Vamorolone trial in Duchenne muscular dystrophy shows dose-related improvement of muscle function

description: Objective: We carried out first-in-patient studies of vamorolone, a
 first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne
 muscular dystrophy. Methods: An open-label, multiple-ascending dose study
 of vamorolone was conducted in 48 boys with Duchenne muscular dystrophy (4
 to &lt;7 years, steroid-naïve). Dose levels were 0.25, 0.75, 2.0 and
 6.0 mg/kg/day using an oral suspension formulation (12 boys/dose level;
 1/3rd to 10x glucocorticoid dose in DMD). Results: Over a 24-week
 treatment period, oral administration of vamorolone at all doses tested
 was safe and well-tolerated. The 2.0 mg/kg/day dose group met the primary
 efficacy outcome of improved muscle function (time to stand; 24 weeks
 vamorolone treatment versus natural history controls), without evidence of
 most adverse effects of glucocorticoids. Significant dose-responsive
 improvements in 10 meter run/walk, and six-minute walk test were observed
 for 2.0 and 6.0 mg/kg/day dose groups. The morbidity of most concern to
 many chronic glucocorticoid users, bone loss, was not seen with vamorolone
 at any dose, as evidenced by serum osteocalcin. Biomarker outcomes for
 adrenal suppression and insulin resistance were also less impacted in
 vamorolone-treated DMD patients, relative to published studies of
 glucocorticoid therapy. Conclusions: Vamorolone demonstrated both efficacy
 and a reduction in adverse effects in DMD patients compared to traditional
 glucocorticoids in a 24-week, open-label study. Vamorolone has potential
 to replace chronic glucocorticoids in many disorders where side effects
 detract from patient quality of life. Classification of Evidence: This
 study provides Class II evidence that certain dosages of vamorolone are
 well tolerated and effective in improving muscle function in DMD.
description: Supplemental
 TablesSupplemental_Figure_1_and_Supplemental_Tables_1_to_13.docx
DOI: 10.5061/dryad.23c646q
title: Data from: Longitudinal characterization of local perfusion of the rat placenta using contrast-enhanced ultrasound imaging

description: The placenta provides a wide range of physiologic functions critical for
 development. Insufficient placental perfusion resulting from improper
 vascular remodeling is linked to many pregnancy-related diseases including
 intrauterine growth restriction and preeclampsia. Here, we use
 contrast-enhanced ultrasound (CEUS) to assess longitudinal, in vivo
 placental perfusion through a pixel-wise time-intensity curve (TIC)
 analysis. CEUS images were acquired of the placenta of pregnant Sprague
 Dawley rats on gestational days (GD) 14, 16, and 18 after a bolus
 injection of gas-filled microbubble contrast agents. Conventionally,
 perfusion can be quantified using a TIC of contrast enhancement in an
 averaged region of interest. However, the placenta has a complex structure
 and flow profile, which is insufficiently described using the conventional
 technique. In this work, we apply curve fitting in each pixel of the CEUS
 image series in order to quantify hemodynamic parameters in the placenta
 and surrounding tissue. We observed an increase in mean placental blood
 volume and relative blood flow from GD14 to 18, while mean transit time of
 the microbubbles decreased, demonstrating an overall rise in placental
 perfusion during gestation. The variance of all three parameters increased
 during gestation showing the regional differences in perfusion observable
 using a pixel-wise TIC approach. Future work will use targeted microbubble
 contrast agents to vascular remodeling in the placenta during pathologies
 of pregnancy.
description: READMEGD14_rawExperimental data of contrast-enhanced ultrasound and b-mode ultrasound cine loops from a normal pregnant Sprague Dawley rat placenta on gestational day 14.GD18_rawExperimental data of contrast-enhanced ultrasound and b-mode ultrasound cine loops of a normal pregnant Sprague Dawley rat placenta on gestational day 18.Interface_preprocessingMatlab script for pre-processing of CEUS images prior to TIC fitInterface_TIC_fitMatlab script for TIC fit and parametric image displayGD16_rawExperimental data of contrast-enhanced ultrasound and b-mode ultrasound cine loops of a normal pregnant Sprague Dawley rat placenta on gestational day 16.
DOI: 10.5061/dryad.56r18rv
title: Data from: Soft-surface grasping: radular opening in Aplysia californica

description: Grasping soft, irregular material is challenging both for animals and
 robots. The feeding systems of many animals have adapted to this
 challenge. In particular, the feeding system of the marine mollusk,
 Aplysia californica, a generalist herbivore, allows it to grasp and ingest
 seaweeds of varying shapes, textures and toughness. On the surface of
 Aplysia's grasper is a structure known as the radula, a thin flexible
 cartilaginous sheet with fine teeth. Previous in vitro studies suggested
 that an intrinsic muscle, I7, is responsible for opening the radula.
 Lesioning I7 in vivo does reduce opening width, but does not prevent
 animals from grasping and ingesting food. New in vitro studies demonstrate
 that a set of fine muscle fibers on the ventral surface of the radula, the
 subradular fibers (SRFs), mediate opening movements even if the I7 muscles
 are absent. Both in vitro and in vivo lesions demonstrate that removing
 the subradular fibers leads to profound deficits in radular opening, and
 significantly reduces feeding efficiency. A theoretical biomechanical
 analysis of the actions of the subradular fibers suggests that they induce
 the radular surface to open around a central crease in the radular surface
 and to arch the radular surface, allowing it to softly conform to
 irregular material. A three-dimensional model of the radular surface,
 based on in vivo observations and magnetic resonance imaging of intact
 animals, provides support for the biomechanical analysis. These results
 suggest how a soft grasper can work during feeding, and suggest novel
 designs for artificial soft graspers.
description: Kehl_Double_Lesion_Open_Ridge_measurementsMeasurements of ridge opening after both I7 and sub-radular fiber lesionsKehl_I7Lesion_Open_Ridge_measurementsEffects of I7 lesions on ridge openingKehl_in_vitro_opening_magnitudesIn vitro opening magnitudes in response to all lesionsKehl_Model_Open_Ridge_measurementsMeasurement of ridge opening in modelKehl_Open_Ridge_MeasurementsRidge measurements in response to multiple lesion conditionsKehl_Sham_Open_Ridge_measurementsMeasurements of ridge in sham lesion animalsKehl_SubRadular_Fiber_Open_Ridge_measurementsMeasurement of ridge in animals subjected to a subradular fiber lesionFeedingEfficiencyDataMeasurements of feeding efficiency after different lesion conditionsOpeningDataMeasurements of opening in response to different lesion conditionsMeasurementsNewModelMeasurements of normalized opening width and of ridge formation from the revised kinetic model of the radular surfaceKehl SRFL Model Measurements.xlsx
DOI: 10.5281/zenodo.18391193
title: NOVAC_BRAND7_150F_4_23C_0k_EDLC_single

description: MetSuperCap Project Dataset 150F SC sample 4 Novac - EDLC Single - Brand7Part of the Constant Temperature DataBase
DOI: 10.82294/dvnwdqfgt
title: Entrevistas semiestructuradas. Territorio: Caquetá. Sector: Cultura. Año: 2024

description: A partir de un proceso de acompañamiento situado, se recopilaron testimonios por medio de entrevistas semiestructuradas durante el año 2024, las cuales indagaron sobre 4 categorías que describían la práctica en educación artística de docentes, cultores, sabedores de la enseñanza del arte, que hacían parte de los programas de formación en educación artística y cultural del sector Cultura (educación informal) en el departamento de Caquetá.
DOI: 10.5281/zenodo.18391192
title: NOVAC_BRAND7_150F_4_23C_0k_EDLC_single

description: MetSuperCap Project Dataset 150F SC sample 4 Novac - EDLC Single - Brand7Part of the Constant Temperature DataBase
DOI: 10.5061/dryad.qk54fq6
title: Data from: Pearls & Oy-sters: Adolescent-onset adrenomyeloneuropathy and arrested cerebral adrenoleukodystrophy

description: Pearls: Defects in peroxisomal transport interferes with β-oxidation of
 very long chain fatty acids (VLCFAs). Subsequent VLCFA accumulation
 triggers a cascade of events that eventually leads to adrenoleukodystrophy
 (ALD). Attention-deficit/hyperactivity disorder (ADHD) can be one of the
 early manifestations of childhood cerebral ALD (CCALD). Patients with
 adrenomyeloneuropathy (AMN) may have signs of occult self-halted CCALD on
 MRI, which can help point to a diagnosis of AMN. Oy-sters: AMN can present
 in adolescence, although it typically presents in adult men between 20 and
 40 years of age, and at older age in women. MRI findings in the spinal
 cord could be normal or show minimal white matter involvement with
 significant bilateral spastic paraparesis. Blood pressure, glucose, and
 electrolytes can be normal in patients with adrenal insufficiency.
description: Appendix
 2
DOI: 10.5061/dryad.56m57q8
title: Data from: Site specific distribution of oak rhizosphere associated oomycetes revealed by cytochrome c oxidase subunit II metabarcoding

description: The phylum Oomycota comprises important tree pathogens like Phytophthora
 quercina, involved in central European oak decline, and P. cinnamomi shown
 to affect holm oaks among many other hosts. Despite the importance to
 study the distribution, dispersal and niche partitioning of this phylum,
 metabarcoding surveys and studies considering environmental factors that
 could explain oomycete community patterns are still rare. We investigated
 oomycetes in the rhizosphere of evergreen oaks in a Spanish oak woodland
 using metabarcoding based on Illumina sequencing of the taxonomic marker
 cytochrome c oxidase subunit II (cox2). We developed an approach
 amplifying a 333 bp long fragment using the forward primer Hud-F
 (Hudspeth, Nadler, & Hudspeth, 2000) and a reverse primer found
 using DegePrime (Hugerth et al., 2014). Factors reflecting topo-edaphic
 conditions and tree health were linked to oomycete community patterns. The
 majority of detected OTUs belonged to the Peronosporales. Most taxa were
 relatives of the Pythiaceae, but relatives of the Peronosporaceae and
 members of the Saprolegniales were also found. The most abundant OTUs were
 related to Globisporangium irregulare and Phytophthora cinnamomi, both
 displaying strong site specific patterns. Oomycete communities were
 strongly correlated with the environmental factors: altitude, crown
 foliation, slope and soil skeleton and soil nitrogen. Our findings
 illustrate the significance of small scale variation in habitat conditions
 for the distribution of oomycetes and highlights the importance to study
 oomycete communities in relation to such ecological patterns.
description: Cytochrome c oxidase
 subunit II (cox2) sequences of oomycota for uparseReference sequence
 database of oomycete cox2 sequences and decoi sequences of fungi and
 Viridiplantae for analysis of metabarcoding data using
 uparsecox2_oomycete_refDB_uparse_v10_Sappetal.txt