cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.18431349
title: Drinking Water Access Deprivation Modelled Dataset in Kano, Nigeria

description: Produced as part of the IDEAMAPS Data Ecosystem project, this dataset maps relative levels of difficulty in accessing safe and reliable drinking water across urban areas. It provides a spatial representation of access constraints by combining physical accessibility, service reliability, and demand pressures at the neighbourhood level. Model focus and indicators were prioritised through community engagement and validation exercises, ensuring that the representation of access deprivation reflects lived experiences and locally relevant conditions in the study areas.The model explicitly incorporates a gender lens by recognising that, while both men and women may participate in water collection, women remain primarily responsible for household water use and management. As a result, women are disproportionately exposed to time burdens, queuing, and service reliability failures. Despite carrying the bulk of water-related labour, women are often underrepresented in decision-making regarding drinking water at both household and community levels. This imbalance between responsibility and authority means that drinking water access is analysed not only as an infrastructural challenge, but as a factor with direct implications for women’s empowerment, particularly in terms of agency, participation, and control over resources.
DOI: 10.17632/phw7g694kr
title: Metabolomics-Based Investigation of PFOS-Induced Molecular Perturbations Across Multiple Rat Organs.

description: This study aimed to investigate the perfluorooctane sulfonic acid (PFOS)-induced metabolic alterations in several organs and establish the potential mechanisms underlying the organ toxicity. A nuclear magnetic resonance-based metabolomics approach was employed to analyze metabolic alterations in multiple organs and serum of male rats exposed to varying doses of PFOS. We observed significant alterations in metabolites associated with inflammation (e.g., uridine diphosphate glucose), energy metabolism (e.g., adenosine monophosphate and adenosine triphosphate), amino acid (e.g., branched-chain amino acids), carbohydrate metabolism, and oxidative stress modulation (e.g., glutathione and taurine) in several organs. These alterations could be linked to inflammation, fibrosis, mitochondrial dysfunction, insulin resistance, and oxidative stress. Succinate accumulation was observed in the heart and liver, suggesting the susceptibility of these organs to mitochondrial dysfunction. Overall, our findings revealed potential key molecular events triggered by PFOS exposure, contributing to a deeper understanding of the possible adverse effects on multiple organs.
DOI: 10.5281/zenodo.18431348
title: Drinking Water Access Deprivation Modelled Dataset in Kano, Nigeria

description: Produced as part of the IDEAMAPS Data Ecosystem project, this dataset maps relative levels of difficulty in accessing safe and reliable drinking water across urban areas. It provides a spatial representation of access constraints by combining physical accessibility, service reliability, and demand pressures at the neighbourhood level. Model focus and indicators were prioritised through community engagement and validation exercises, ensuring that the representation of access deprivation reflects lived experiences and locally relevant conditions in the study areas.The model explicitly incorporates a gender lens by recognising that, while both men and women may participate in water collection, women remain primarily responsible for household water use and management. As a result, women are disproportionately exposed to time burdens, queuing, and service reliability failures. Despite carrying the bulk of water-related labour, women are often underrepresented in decision-making regarding drinking water at both household and community levels. This imbalance between responsibility and authority means that drinking water access is analysed not only as an infrastructural challenge, but as a factor with direct implications for women’s empowerment, particularly in terms of agency, participation, and control over resources.
DOI: 10.17632/phw7g694kr.2
title: Metabolomics-Based Investigation of PFOS-Induced Molecular Perturbations Across Multiple Rat Organs.

description: This study aimed to investigate the perfluorooctane sulfonic acid (PFOS)-induced metabolic alterations in several organs and establish the potential mechanisms underlying the organ toxicity. A nuclear magnetic resonance-based metabolomics approach was employed to analyze metabolic alterations in multiple organs and serum of male rats exposed to varying doses of PFOS. We observed significant alterations in metabolites associated with inflammation (e.g., uridine diphosphate glucose), energy metabolism (e.g., adenosine monophosphate and adenosine triphosphate), amino acid (e.g., branched-chain amino acids), carbohydrate metabolism, and oxidative stress modulation (e.g., glutathione and taurine) in several organs. These alterations could be linked to inflammation, fibrosis, mitochondrial dysfunction, insulin resistance, and oxidative stress. Succinate accumulation was observed in the heart and liver, suggesting the susceptibility of these organs to mitochondrial dysfunction. Overall, our findings revealed potential key molecular events triggered by PFOS exposure, contributing to a deeper understanding of the possible adverse effects on multiple organs.
DOI: 10.17632/5jjds7csy3
title: Identification of a Csf2rb-dependent yolk sac developmental pathway generating distinct liver-resident Itga4+ macrophages

description: The functional diversity of tissue-resident macrophages (RTMs) is shaped by both their developmental origins, including the yolk sac, fetal liver, and bone marrow, as well as the local tissue microenvironment. However, the heterogeneity of embryonic-derived RTMs remains poorly characterized. In this study, we integrated single-cell transcriptomic data of human and mouse embryos to establish a cross-species framework for defining human yolk sac-derived RTMs. We identified three evolutionarily conserved erythro-myeloid progenitor (EMP) populations in the yolk sac and uncovered two distinct developmental trajectories defined by lysozyme expression: Lyz2-negative and Lyz2-positive lineages. Lyz2-CD117+CD45-CD93- early-EMPs differentiate into mature macrophages through Lyz2-CD117+CD45+CD93- intermediate-EMPs in a Csf2rb-dependent Lyz2-negative manner. This Csf2rb-dependent Lyz2-negative EMP lineage generates a unique Itga4+ macrophage population in the liver. These Lyz2-negative liver-resident macrophages exhibit distinct transcriptional profiles and promote tumorigenesis during early hepatocellular carcinoma, in contrast to liver-resident macrophages derived from the Lyz2-positive EMP lineage. Moreover, the balance between these functionally divergent macrophage lineages regulates the tumor susceptibility of the tissue microenvironment. Our findings underscores that developmental origin critically contributes to the substantial heterogeneity observed in RTMs.
DOI: 10.17632/5jjds7csy3.1
title: Identification of a Csf2rb-dependent yolk sac developmental pathway generating distinct liver-resident Itga4+ macrophages

description: The functional diversity of tissue-resident macrophages (RTMs) is shaped by both their developmental origins, including the yolk sac, fetal liver, and bone marrow, as well as the local tissue microenvironment. However, the heterogeneity of embryonic-derived RTMs remains poorly characterized. In this study, we integrated single-cell transcriptomic data of human and mouse embryos to establish a cross-species framework for defining human yolk sac-derived RTMs. We identified three evolutionarily conserved erythro-myeloid progenitor (EMP) populations in the yolk sac and uncovered two distinct developmental trajectories defined by lysozyme expression: Lyz2-negative and Lyz2-positive lineages. Lyz2-CD117+CD45-CD93- early-EMPs differentiate into mature macrophages through Lyz2-CD117+CD45+CD93- intermediate-EMPs in a Csf2rb-dependent Lyz2-negative manner. This Csf2rb-dependent Lyz2-negative EMP lineage generates a unique Itga4+ macrophage population in the liver. These Lyz2-negative liver-resident macrophages exhibit distinct transcriptional profiles and promote tumorigenesis during early hepatocellular carcinoma, in contrast to liver-resident macrophages derived from the Lyz2-positive EMP lineage. Moreover, the balance between these functionally divergent macrophage lineages regulates the tumor susceptibility of the tissue microenvironment. Our findings underscores that developmental origin critically contributes to the substantial heterogeneity observed in RTMs.
DOI: 10.17632/wg5j24yhkm
title: Supplementary Simulation Code and Anonymized Topology Data for Port Resilience Analysis

description: Dataset Description:
This repository contains the source code and necessary datasets to reproduce the simulation results presented in the manuscript regarding port system recovery dynamics.

Contents:

Code (/src): Python implementations of the differential equations for resource mobilization and the heuristic allocation algorithm.
Data (/data):
topology_matrix.csv: Anonymized adjacency matrix representing the port operational network.
parameters.json: Configuration files for simulation scenarios (including weight settings derived from expert elicitation).
Scripts: main.py is provided to execute the comparative analysis between Closed-loop and Open-loop control strategies.
Environment:
Code is compatible with Python 3.8+. See requirements.txt for dependencies.
DOI: 10.17632/wg5j24yhkm.1
title: Supplementary Simulation Code and Anonymized Topology Data for Port Resilience Analysis

description: Dataset Description:
This repository contains the source code and necessary datasets to reproduce the simulation results presented in the manuscript regarding port system recovery dynamics.

Contents:

Code (/src): Python implementations of the differential equations for resource mobilization and the heuristic allocation algorithm.
Data (/data):
topology_matrix.csv: Anonymized adjacency matrix representing the port operational network.
parameters.json: Configuration files for simulation scenarios (including weight settings derived from expert elicitation).
Scripts: main.py is provided to execute the comparative analysis between Closed-loop and Open-loop control strategies.
Environment:
Code is compatible with Python 3.8+. See requirements.txt for dependencies.
DOI: 10.17632/stzmr3h37c
title: Impact of Obstructive Sleep Apnea on Cardiovascular Events After Ischemic Stroke

description: Dataset for Impact of Obstructive Sleep Apnea on Cardiovascular Events After Ischemic Stroke
DOI: 10.17632/stzmr3h37c.1
title: Impact of Obstructive Sleep Apnea on Cardiovascular Events After Ischemic Stroke

description: Dataset for Impact of Obstructive Sleep Apnea on Cardiovascular Events After Ischemic Stroke
DOI: 10.15468/dl.bw275c
title: Occurrence Download

description: A dataset containing 772 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Blakea multiflora",
 "HasCoordinate is true",
 "BasisOfRecord is one of (Specimen)"
 ]
}

 The dataset includes 772 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007815-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/j8jrrn4t9k
title: Anti-SLC7A11 monoclonal antibody Inhibits Tumor Progression through a Janus-faced Effect on CD4+ and CD8+ T Cells in Colorectal Cancer

description: While chimeric antigen receptor T cell therapy has demonstrated significant efficacy in treating hematological malignancies, its application in solid tumors remains challenging. A primary factor contributing to the limited efficacy of CAR-T cells in solid tumors is the dysfunction of CD8+ T cells, which is often a result of exhaustion. However, emerging evidence suggests that modulating cellular metabolism holds promise for enhancing the functionality of CD8+ T cells. An experimental model of CD8⁺ T cell exhaustion was established, followed by RNA sequencing to profile the expression of SLC family genes, which are implicated in metabolic regulation and CD8⁺ T cell differentiation. Monoclonal antibodies were generated using hybridoma technology and subsequently humanized. The effects of antibody treatment on CD8⁺ T cell differentiation and exhaustion were assessed via flow cytometry and western blotting. To evaluate therapeutic efficacy, cell-derived xenograft models of colorectal and breast cancer were established, and the combined effect of the antibody with CAR-T cells was examined. Furthermore, CRISPR/Cas9-mediated gene-edited mouse models were generated, and single-cell sequencing was performed to monitor changes in tumor burden and the differentiation status of tumor-infiltrating CD8⁺ T cells. RNA sequencing analysis revealed that SLC7A11 was significantly upregulated in exhausted CD8⁺ T cells. A monoclonal antibody specifically targeting SLC7A11 was generated, and its binding affinity was rigorously validated. Functional studies demonstrated that inhibition of SLC7A11 promoted the expansion of CD8⁺ T stem cell memory cells and attenuated the exhausted phenotype. In vivo studies further showed that anti-SLC7A11 treatment enhanced the antitumor efficacy of CAR-T cells. The effects were mediated through the suppression of cystine uptake via SLC7A11 inhibition, thereby modulating the GCN2-eIF2α-SLC1A5 signaling axis. Restricting cystine uptake enhances the efficacy of CD8+ CAR-T cells and alleviates tumor burden.
DOI: 10.17632/j8jrrn4t9k.1
title: Anti-SLC7A11 monoclonal antibody Inhibits Tumor Progression through a Janus-faced Effect on CD4+ and CD8+ T Cells in Colorectal Cancer

description: While chimeric antigen receptor T cell therapy has demonstrated significant efficacy in treating hematological malignancies, its application in solid tumors remains challenging. A primary factor contributing to the limited efficacy of CAR-T cells in solid tumors is the dysfunction of CD8+ T cells, which is often a result of exhaustion. However, emerging evidence suggests that modulating cellular metabolism holds promise for enhancing the functionality of CD8+ T cells. An experimental model of CD8⁺ T cell exhaustion was established, followed by RNA sequencing to profile the expression of SLC family genes, which are implicated in metabolic regulation and CD8⁺ T cell differentiation. Monoclonal antibodies were generated using hybridoma technology and subsequently humanized. The effects of antibody treatment on CD8⁺ T cell differentiation and exhaustion were assessed via flow cytometry and western blotting. To evaluate therapeutic efficacy, cell-derived xenograft models of colorectal and breast cancer were established, and the combined effect of the antibody with CAR-T cells was examined. Furthermore, CRISPR/Cas9-mediated gene-edited mouse models were generated, and single-cell sequencing was performed to monitor changes in tumor burden and the differentiation status of tumor-infiltrating CD8⁺ T cells. RNA sequencing analysis revealed that SLC7A11 was significantly upregulated in exhausted CD8⁺ T cells. A monoclonal antibody specifically targeting SLC7A11 was generated, and its binding affinity was rigorously validated. Functional studies demonstrated that inhibition of SLC7A11 promoted the expansion of CD8⁺ T stem cell memory cells and attenuated the exhausted phenotype. In vivo studies further showed that anti-SLC7A11 treatment enhanced the antitumor efficacy of CAR-T cells. The effects were mediated through the suppression of cystine uptake via SLC7A11 inhibition, thereby modulating the GCN2-eIF2α-SLC1A5 signaling axis. Restricting cystine uptake enhances the efficacy of CD8+ CAR-T cells and alleviates tumor burden.
DOI: 10.17632/gt3nzyz8hf.1
title: ER-25-20491 research data

description: Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Data for Molecular Composition of Dissolved Organic Matter
DOI: 10.15468/dl.k5jkfn
title: Occurrence Download

description: A dataset containing 92 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Senecio otophorus"
 ]
}

 The dataset includes 92 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007816-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.357msa
title: Occurrence Download

description: A dataset containing 1352 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Coronilla vaginalis, Coronilla vaginalis)",
 "Year is greater than or equal to 1900",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 1352 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007817-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qk7kf6
title: Occurrence Download

description: A dataset containing 2637 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Corynephorus canescens, Weingaertneria canescens)",
 "Year is greater than or equal to 1900",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 2637 records from 14 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007819-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dwbfjp
title: Occurrence Download

description: A dataset containing 29539 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Coronilla varia, Securigera varia)",
 "Year is greater than or equal to 1900",
 "Geometry POLYGON ((8.643 46.99, 14.1 46.92, 14.43 50.75, 8.534 50.83, 8.643 46.99))",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Observation, Human Observation, Machine Observation, Material sample)"
 ]
}

 The dataset includes 29539 records from 48 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007818-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/wd55vcryt9.2
title: Reproducibility package (code + published tables only; no redistributed cohort data) for: Climatic instability, functional ageing, and mortality in older adults in China: a dual-cohort longitudinal study

description: This dataset contains a reproducibility package (analysis code and published summary result tables) for the study:

“Climatic instability, functional ageing, and mortality in older adults in China: a dual-cohort longitudinal study”.

The analyses use two national cohort studies in China (CHARLS and CLHLS). No restricted or licensed cohort microdata are redistributed in this upload. In particular, this upload does not include any downloaded CHARLS/CLHLS datasets (in whole or in part), nor any participant-level records or identifiers. The original cohort data must be obtained directly from the official data providers under their application procedures and data-use agreements.

The package includes: (i) curated analysis scripts, (ii) documentation/manifests for file integrity, and (iii) small numeric tables that correspond to values already shown in the manuscript/appendix.
DOI: 10.15468/dl.grqxrv
title: Occurrence Download

description: A dataset containing 39352 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Tadarida brasiliensis"
 ]
}

 The dataset includes 39352 records from 263 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007820-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tsz82q
title: Occurrence Download

description: A dataset containing 18287 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "TaxonKey is Scorzonera laciniata"
 ]
}

 The dataset includes 18287 records from 397 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0049937-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/12822997
title: Peer-to-Peer Boliviano (BOB) Exchange Data
DOI: 10.3886/e231549
title: Replication data for: Unmeasured Investment and the Puzzling US Boom in the 1990s

description: For the 1990s, the basic neoclassical growth model predicts a depressed economy, when in fact the US economy boomed. We extend the base model by introducing intangible investment and non-neutral technology change with respect to producing intangible investment goods and find that the 1990s are not puzzling in light of this new theory. There is microeconomic and macroeconomic evidence motivating our extension, and the theory's predictions are in conformity with US national accounts and capital gains. We compare accounting measures with corresponding measures for our model economy and find that standard accounting measures greatly understate the 1990s boom. (JEL E22, E23, O33, O47)
DOI: 10.3886/e231549v1
title: Replication data for: Unmeasured Investment and the Puzzling US Boom in the 1990s

description: For the 1990s, the basic neoclassical growth model predicts a depressed economy, when in fact the US economy boomed. We extend the base model by introducing intangible investment and non-neutral technology change with respect to producing intangible investment goods and find that the 1990s are not puzzling in light of this new theory. There is microeconomic and macroeconomic evidence motivating our extension, and the theory's predictions are in conformity with US national accounts and capital gains. We compare accounting measures with corresponding measures for our model economy and find that standard accounting measures greatly understate the 1990s boom. (JEL E22, E23, O33, O47)