DOI: 10.5061/dryad.vq83bk3sf
title: Subjective sleep quality and sleep architecture in patients with migraine: a meta-analysis

description: Sleep disturbance is often associated with migraine. However, there is a
 paucity of research investigating objective and subjective measures of
 sleep in migraine patients. This meta-analysis aims to determine whether
 there are differences in subjective sleep quality measured using the
 Pittsburgh Sleep Quality Index (PSQI), and objective sleep physiology
 measured using polysomnography between adult and pediatric patients, and
 healthy controls. This review was pre-registered on PROSPERO
 (CRD42020209325). A systematic search of five databases (Embase, MEDLINE®,
 Global Health, APA PsycINFO, APA PsycArticles, last searched: 12/17/2020)
 was conducted to find case-controlled studies that measured
 polysomnography and/or PSQI in patients with migraine. Pregnant
 participants and those with other headache disorders were excluded. Effect
 sizes (Hedges’ g) were entered into a random effects model meta-analysis.
 Study quality was evaluated with the Newcastle Ottawa Scale and
 publication bias with Egger’s regression test. 32 studies were
 eligible, of which 21 measured PSQI and/or MIDAS in adults, 6 measured PSG
 in adults, and 5 in children. The overall mean study quality score was
 5/9, and this did not moderate any of the results, and there was no risk
 of publication bias. Overall, adults with migraine had higher PSQI scores
 than healthy controls (g=0.75, p &lt; .001, 95% confidence interval
 [95% CI]: 0.54 - 0.96). This effect was larger in those with chronic
 rather than episodic conditions (g=1.03, p &lt; .001, 95% CI: 0.37 -
 1.01, g = 0.63, p &lt; .001, 95% CI: 0.38 - 0.88
 respectively). For polysomnographic studies, adults and children with
 migraine displayed a lower percentage of REM sleep (g=-0.22, p = 0.017,
 95% CI: -0.41 - -0.04, g = -0.71, p = 0.025, 95% CI: -1.34 -
 -0.10 respectively) than controls. Pediatric patients displayed less total
 sleep time (g=-1.37, p = 0.039, 95% CI: -2.66 - -0.10), more wake (g=0.52,
 p &lt; .001, 95% CI: 0.08 – 0.79) and shorter sleep onset latency
 (g=-0.37, p &lt; .001, 95% CI: -0.54 - -0.21) than
 controls. People with migraines have significantly poorer
 subjective sleep quality and altered sleep physiology compared to healthy
 individuals. Further longitudinal empirical studies are required to
 enhance our understanding of this relationship.
description: This dataset includes the means and standard deviations from
 adult and paediatric migraine patients and healthy controls for global
 Pittsburgh Sleep Quality Index scores, and polysomnography parameters
 (REM, N1, N2, N3, wake percentages, total sleep time, and sleep onset
 latency in minutes) as well as the <em>n</em> for each group
 taken directly from published journal articles. The dataset also includes
 other information such as the original article's authors, title of
 the article, country of publication, abstract, year published, journal
 published in, the measures of sleep that the study collected, risk of
 bias/study quality assessment scores, and other information that could be
 potential moderating variables.
description: # Subjective sleep quality and sleep architecture in patients with
 migraine: a meta-analysis
 [https://doi.org/10.5061/dryad.vq83bk3sf](https://doi.org/10.5061/dryad.vq83bk3sf) There is an additional README file within the RStudio software project that explains how to run the necessary analysis scripts. Data are stored in .csv format. Each file contains a different sleep measure (PSQI, PSG, MIDAS & PSQI) for migraine patients and controls. In each file, there are the following columns: * 1\) Authors_year - detailing the authors and year of the published journal article. * 2\) Country of publication - the country the article was published in. * 3\) Publication Type - what type of publication it is * 4\) Year - the year the article was published * 5\) Journal - the peer-reviewed journal that the article was published in * 6\) M_n = this indicates the sample size (n) for that respective parameter for the migraine group (M) * 7\) M_M = this indicates the mean of the migraine group (M) for that particular sleep parameter * 8\) M_sd = this indicates the standard deviation for the migraine group for that particular sleep parameter * 9\) C_n = this indicates the sample size (n) for that respective parameter for the control group (C) * 10\) C_M = this indicates the mean of the control group (C) for that particular sleep parameter * 11\) C_sd = this indicates the standard deviation for the healthy control group (C) for that particular sleep parameter * 12\) migraine_frequency = this indicates the frequency of migraine which that article studies/includes * 13\) drug_control = this indicates whether the study in question excluded patients on medication/drugs which would affect the sleep cycle or not * 14\) sleep_disorders = this indicates whether or not the study in question excluded participants with sleep disorders * 15\) matched_controls = this indicates whether or not the study in question matched their control population to their migraine population based on sex and age * 16\) ROB_score = this indicates the risk of bias score or study quality score out of 6 for each study which is based on the Newcastle Ottawa Scale.