cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6189041.v3
title: A systematic quality review of high-tech AAC interventions as an evidence-based practice

description: Although high-tech augmentative and alternative communication (AAC) is commonly used to teach social-communication skills to people with autism spectrum disorder or intellectual disabilities who have complex communication needs, there is a critical need to evaluate the efficacy of this approach. The aim of this systematic review was to evaluate the quality of single-case experimental design research on the use of high-tech AAC to teach social-communication skills to individuals with autism spectrum disorder or intellectual disabilities who have complex communication needs, to determine if this intervention approach meets the criteria for evidence-based practices as outlined by the What Works Clearinghouse. Additionally, information on the following extended methodological standards is reported on all included studies: participant description, description of setting and materials, interventionist description, baseline and intervention description, maintenance, generalization, procedural integrity, and social validity. The results from 18 multiple-baseline or multiple-probe experiments across 17 studies indicate that using high-tech AAC to teach social-communication skills to individuals with autism spectrum disorder or intellectual disabilities and complex communication needs can be considered an evidence-based practice, although the review of comparison (i.e., alternating treatment) design studies did not indicate that high-tech AAC is significantly better than low-tech AAC.
DOI: 10.6084/m9.figshare.6189041.v2
title: A systematic quality review of high-tech AAC interventions as an evidence-based practice

description: Although high-tech augmentative and alternative communication (AAC) is commonly used to teach social-communication skills to people with autism spectrum disorder or intellectual disabilities who have complex communication needs, there is a critical need to evaluate the efficacy of this approach. The aim of this systematic review was to evaluate the quality of single-case experimental design research on the use of high-tech AAC to teach social-communication skills to individuals with autism spectrum disorder or intellectual disabilities who have complex communication needs, to determine if this intervention approach meets the criteria for evidence-based practices as outlined by the What Works Clearinghouse. Additionally, information on the following extended methodological standards is reported on all included studies: participant description, description of setting and materials, interventionist description, baseline and intervention description, maintenance, generalization, procedural integrity, and social validity. The results from 18 multiple-baseline or multiple-probe experiments across 17 studies indicate that using high-tech AAC to teach social-communication skills to individuals with autism spectrum disorder or intellectual disabilities and complex communication needs can be considered an evidence-based practice, although the review of comparison (i.e., alternating treatment) design studies did not indicate that high-tech AAC is significantly better than low-tech AAC.
DOI: 10.6084/m9.figshare.6188918
title: Supplementary Material for: Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy

description: <b><i>Background:</i></b> Currently, there is an urgent need to find ways of identifying primary membranous nephropathy (PMN) patients who are likely to benefit from calcineurin inhibitors (CNI) or who are resistant to them. In this study, we employed nano-HPLC-MS/MS analysis to identify serum biomarkers that predict the clinical response to CNI therapy in PMN patients. <b><i>Methods:</i></b> The endpoint was complete remission (CR) after CNI treatment. PMN patients were grouped into no-remission (NR) or CR groups to screen predictive candidates using the nano-HPLC-MS/MS analysis. <b><i>Results:</i></b> Compared with NR patients, 3 upregulated proteins and 5 downregulated proteins were found to present a twofold change in CR patients’ serum. Serum amyloid A1 protein (SAA1) was further validated by ELISA; it was decreased in patients in the NR group compared with patients in the CR group, but SAA1 in patients in these groups was lower than in healthy controls and minimal change disease patients. The area under the receiver operating characteristic (ROC) curve of SAA1 was used to distinguish PMN NR patients from those in remission and was 0.901, with a sensitivity of 78.3% and specificity of 86.8%, similar to that of the phospholipase A2 receptor (PLA2R) antibody. Combining SAA1 with the PLA2R antibody, the area under the ROC curve was 0.956, which was higher than that of SAA1 or the PLA2R antibody alone. <b><i>Conclusions:</i></b> Serum SAA1 may be a candidate PMN biomarker that can be used to discriminate CNI NR cases from remission patients. The combination of SAA1 and the PLA2R antibody increases the accuracy of diagnosis.
DOI: 10.6084/m9.figshare.6188918.v1
title: Supplementary Material for: Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy

description: <b><i>Background:</i></b> Currently, there is an urgent need to find ways of identifying primary membranous nephropathy (PMN) patients who are likely to benefit from calcineurin inhibitors (CNI) or who are resistant to them. In this study, we employed nano-HPLC-MS/MS analysis to identify serum biomarkers that predict the clinical response to CNI therapy in PMN patients. <b><i>Methods:</i></b> The endpoint was complete remission (CR) after CNI treatment. PMN patients were grouped into no-remission (NR) or CR groups to screen predictive candidates using the nano-HPLC-MS/MS analysis. <b><i>Results:</i></b> Compared with NR patients, 3 upregulated proteins and 5 downregulated proteins were found to present a twofold change in CR patients’ serum. Serum amyloid A1 protein (SAA1) was further validated by ELISA; it was decreased in patients in the NR group compared with patients in the CR group, but SAA1 in patients in these groups was lower than in healthy controls and minimal change disease patients. The area under the receiver operating characteristic (ROC) curve of SAA1 was used to distinguish PMN NR patients from those in remission and was 0.901, with a sensitivity of 78.3% and specificity of 86.8%, similar to that of the phospholipase A2 receptor (PLA2R) antibody. Combining SAA1 with the PLA2R antibody, the area under the ROC curve was 0.956, which was higher than that of SAA1 or the PLA2R antibody alone. <b><i>Conclusions:</i></b> Serum SAA1 may be a candidate PMN biomarker that can be used to discriminate CNI NR cases from remission patients. The combination of SAA1 and the PLA2R antibody increases the accuracy of diagnosis.
DOI: 10.6084/m9.figshare.6188849
title: Supplementary Material for: The Novel Biomarker of Germ Cell Tumours, Micro-RNA-371a-3p, Has a Very Rapid Decay in Patients with Clinical Stage 1

description: <b><i>Background:</i></b> Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker of testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity of decline of serum levels in response to treatment. <b><i>Patients and Methods:</i></b> Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively and repeatedly on the following 3 days. Three had additional tests done within 24 h after surgery. Measurement results were analysed using descriptive statistical methods. <b><i>Results:</i></b> Serum levels dropped to 2.62, 1.27, and 0.47% of the preoperative level within 1, 2, and 3 days, respectively. The computed half-life amounts to 3.7–7 h. The velocity of decay is significantly associated with tumour size. <b><i>Conclusions:</i></b> Serum-levels of miR-371a-3p have a short half-life of less than 12 h. The rapid decay after treatment represents a valuable feature confirming the usefulness of miR-371a-3p as a valuable serum biomarker of GCT.
DOI: 10.6084/m9.figshare.6188849.v1
title: Supplementary Material for: The Novel Biomarker of Germ Cell Tumours, Micro-RNA-371a-3p, Has a Very Rapid Decay in Patients with Clinical Stage 1

description: <b><i>Background:</i></b> Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker of testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity of decline of serum levels in response to treatment. <b><i>Patients and Methods:</i></b> Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively and repeatedly on the following 3 days. Three had additional tests done within 24 h after surgery. Measurement results were analysed using descriptive statistical methods. <b><i>Results:</i></b> Serum levels dropped to 2.62, 1.27, and 0.47% of the preoperative level within 1, 2, and 3 days, respectively. The computed half-life amounts to 3.7–7 h. The velocity of decay is significantly associated with tumour size. <b><i>Conclusions:</i></b> Serum-levels of miR-371a-3p have a short half-life of less than 12 h. The rapid decay after treatment represents a valuable feature confirming the usefulness of miR-371a-3p as a valuable serum biomarker of GCT.
DOI: 10.6084/m9.figshare.6188843.v1
title: Research Front Detection and Topic Evolution Based on Topological Structure and PageRank Algorithm

description: this is the raw data used in my article "research fron detection and topic evolution based on topological structure and PageRank algorithm". The data contains raw documents downloaded from Web of Science, similarity between different documents, and similarity between different clustering
DOI: 10.6084/m9.figshare.6188843.v2
title: Research Front Detection and Topic Evolution Based on Topological Structure and PageRank Algorithm

description: this is the raw data used in my article "research fron detection and topic evolution based on topological structure and PageRank algorithm". The data contains raw documents downloaded from Web of Science, similarity between different documents, and similarity between different clustering
DOI: 10.6084/m9.figshare.6188843.v3
title: Research Front Detection and Topic Evolution Based on Topological Structure and PageRank Algorithm

description: this is the data used in my article "research front detection and topic evolution based on topological structure and PageRank algorithm". The data include the scientific documents in Dataset I (D1.txt), the scientific documents in Dataset II (D2.txt), the scientific documents in Dataset I without isolated document (D3.txt), and the scientific documents in Dataset II without isolated document (D4.txt), the unique number of scientific documents (D5.txt), the similarity between scientific documents for document clustering (D6.txt), and the similarity between clusters for topic evolution (D7.txt).
DOI: 10.6084/m9.figshare.6188804
title: Supplementary Material for: Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function

description: <b><i>Background and Aim:</i></b> Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. <b><i>Methods:</i></b> We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. <b><i>Results:</i></b> The diagnoses of the patients were as follows: normal esophageal motility (<i>n</i> = 25), ineffective esophageal motility (<i>n</i> = 5), esophagogastric junction outflow obstruction (EGJOO; <i>n</i> = 10), distal esophageal spasm (<i>n</i> = 5), achalasia (<i>n</i> = 10), absent contractility (<i>n</i> = 1), and jackhammer esophagus (<i>n</i> = 1). The expression of tumor necrosis factor (TNF)-α in the esophagogastric junction (EGJ) was significantly higher in EGJOO (14.6, 14.0–15.8, <i>n</i> = 10) than in normal esophageal motility (13.3, 12.8–14.1, <i>n</i> = 25); however, there was no difference in the expression of TNF-α between achalasia (13.4, 13.0–14.1, <i>n</i> = 10) and normal esophageal motility (13.3, 12.8–14.1, <i>n</i> = 25). EGJOO was discriminated from achalasia/normal by a linear discriminant analysis (AUC = 0.917). A multivariable regression analysis revealed that interleukin (IL)-13 and IL-23A were predictive of the distal contractile integral, whereas TNF-α and IL-6 were predictive of the basal EGJ pressure. <b><i>Conclusions:</i></b> The esophageal motility was associated with mucosally expressed cytokines in humans; these cytokines could be useful targets for the diagnosis and treatment of EMDs.
DOI: 10.6084/m9.figshare.6188720
title: Public-private partnerships: A multi-disciplinary meta-review of the research

description: The spreadsheets provide 1) details of 1,354 papers on Public-Private Partnerships (PPPs) from 605 journals extracted from the Scopus database; 2) an initial ranking of 547 journals by 11 citation-based metrics such as a journal impact factor; and 3) a final ranking of 91 journals publishing 732 papers on PPPs.
DOI: 10.6084/m9.figshare.6188714
title: Appendix A.tiff

description: <b>BACKGROUND</b> This prospective study evaluates outcomes and reoperation rates for unicompartmental knee arthroplasty (UKA) from a single non-designer surgeon using relatively extended criteria of degenerative changes of grade 2 or above in either or both non-operated compartments. <b>METHODS</b> 187 consecutive medial mobile bearing UKA implants were included after history, clinical assessment and radiological evaluation. 91 patients had extended clinical outcomes. Post-operative assessment included functional scoring with the Oxford Knee Score (OKS) and radiographic review. Survivorship curves were constructed using the life-table method, with 95% confidence intervals calculated using Rothman`s equation. Separate endpoints were examined: revision for any reason and revision for confirmed loosening. <b>RESULTS</b> The mean follow-up was 3.5 years. The pre-operative OKS improved from a mean of 21.2 to 38.9 (Mann-Whitney U Test, p=&lt;0.001). Twelve Patients required further operations including 9 revisions. No patients developed deep infection and no surviving implants were loose radiographically. Survivorship at 7 years with endpoints of re-operation, revision and aseptic loosening at surgery or radiographically was 88.4% (95% CI 79.6-93.7), 93.1% (95% CI 85.5-96.9) and 97.3% (95% CI 91.2-99.2) respectively. The presence of pre-operative mild contralateral tibiofemoral or any extent of patellofemoral joint degeneration was of no consequence. <b>DISCUSSION</b> This study shows comparable clinical outcomes of UKA for extended indications from a high volume, high-usage non-designer unit.<b> </b>
DOI: 10.6084/m9.figshare.6188714.v1
title: Appendix A.tiff

description: <b>BACKGROUND</b> This prospective study evaluates outcomes and reoperation rates for unicompartmental knee arthroplasty (UKA) from a single non-designer surgeon using relatively extended criteria of degenerative changes of grade 2 or above in either or both non-operated compartments. <b>METHODS</b> 187 consecutive medial mobile bearing UKA implants were included after history, clinical assessment and radiological evaluation. 91 patients had extended clinical outcomes. Post-operative assessment included functional scoring with the Oxford Knee Score (OKS) and radiographic review. Survivorship curves were constructed using the life-table method, with 95% confidence intervals calculated using Rothman`s equation. Separate endpoints were examined: revision for any reason and revision for confirmed loosening. <b>RESULTS</b> The mean follow-up was 3.5 years. The pre-operative OKS improved from a mean of 21.2 to 38.9 (Mann-Whitney U Test, p=&lt;0.001). Twelve Patients required further operations including 9 revisions. No patients developed deep infection and no surviving implants were loose radiographically. Survivorship at 7 years with endpoints of re-operation, revision and aseptic loosening at surgery or radiographically was 88.4% (95% CI 79.6-93.7), 93.1% (95% CI 85.5-96.9) and 97.3% (95% CI 91.2-99.2) respectively. The presence of pre-operative mild contralateral tibiofemoral or any extent of patellofemoral joint degeneration was of no consequence. <b>DISCUSSION</b> This study shows comparable clinical outcomes of UKA for extended indications from a high volume, high-usage non-designer unit.<b> </b>
DOI: 10.6084/m9.figshare.6188711
title: SupplementaryData.zip

description: Data analyzed and generated in submitted paper "Evolutionary adaptability linked to length variation in short genic tandem Repeats". View in context of scripts available on https://github.com/uio-cels/TandemRepeats/tree/master/scripts.<br>Preprint available on bioRxiv: https://doi.org/10.1101/310045<br>1001 genomes SNP data was downloaded from the 1001 Genomes Consortium Data Center (http://1001genomes.org/data/GMI-MPI/releases/).<br>The RNA-seq dataset: GSE80744_ath1001_tx_norm_2016-04-21-UQ_gNorm_normCounts_k4.tsv.gz<br>was downloaded from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE80744<br>Originally produced in:Kawakatsu T, Huang SC, Jupe F, Sasaki E et al. Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions. Cell 2016 Jul 14;166(2):492-505. PMID: 27419873<br><br>
DOI: 10.6084/m9.figshare.6188711.v1
title: SupplementaryData.zip

description: Data analyzed and generated in submitted paper "Evolutionary adaptability linked to length variation in short genic tandem Repeats". View in context of scripts available on https://github.com/uio-cels/TandemRepeats/tree/master/scripts.<br>Preprint available on bioRxiv: https://doi.org/10.1101/310045
DOI: 10.6084/m9.figshare.6188711.v2
title: SupplementaryData.zip

description: Data analyzed and generated in submitted paper "Evolutionary adaptability linked to length variation in short genic tandem Repeats". View in context of scripts available on https://github.com/uio-cels/TandemRepeats/tree/master/scripts.<br>Preprint available on bioRxiv: https://doi.org/10.1101/310045<br>1001 genomes SNP data was downloaded from the 1001 Genomes Consortium Data Center (http://1001genomes.org/data/GMI-MPI/releases/).<br>The RNA-seq dataset: GSE80744_ath1001_tx_norm_2016-04-21-UQ_gNorm_normCounts_k4.tsv.gz<br>was downloaded from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE80744<br>Originally produced in:Kawakatsu T, Huang SC, Jupe F, Sasaki E et al. Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions. Cell 2016 Jul 14;166(2):492-505. PMID: 27419873<br><br>
DOI: 10.6084/m9.figshare.6188672.v1
title: Public-private partnerships: A multi-disciplinary meta-review of the research

description: The spreadsheets provide 1) details of 1,354 papers on Public-Private Partnerships (PPPs) from 605 journals extracted from the Scopus database; 2) an initial ranking of 547 journals by 11 citation-based metrics such as a journal impact factor; and 3) a final ranking of 91 journals publishing 732 papers on PPPs.
DOI: 10.6084/m9.figshare.6188570
title: Supplementary Material for: Long-Term Hearing Outcomes following Stapedotomy in Patients with Otosclerosis and Preoperative Small Air-Bone Gap

description: <b><i>Objectives:</i></b> To assess the long-term effectiveness of stapedotomies performed on patients with otosclerosis and preoperative small air-bone gaps (ABGs). <b><i>Methods:</i></b> Retrospective study comparing the 10-year postoperative hearing outcomes after primary stapedotomies in patients with small (≤20 dB) and large ABGs (&gt; 20 dB). Ninety out of 175 stapedotomies (22 and 68 in the small and large ABG groups, respectively) were monitored with long-term follow-ups. <b><i>Results:</i></b> Ten years after the operation, hearing measurements were similar for both groups, although a significant decline of bone conduction thresholds was evident (<i>p</i> = 0.007 and <i>p</i> &lt; 0.001, respectively). An improvement of ≥10 dB in the postoperative ABG (clinical improvement) was achieved only in the large ABG group. <b><i>Conclusions:</i></b> Even though long-term hearing levels will evolve similarly in patients with ≤20 and &gt; 20 dB preoperative ABGs, the lack of clinical improvement found in the small ABG group is not in favor of an early surgery.
DOI: 10.6084/m9.figshare.6188516
title: Supplementary Material for: Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in <b><i>Fez1</i></b>-Deficient Mice

description: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that, while prevalent, has a stagnant track record for advances in treatment. The limited availability of animal models with appropriate face and predictive validities has hampered progress in developing novel neurobiological hypotheses and testing new therapeutic options for this condition. Here, we report that mice deficient in <i>Fez1</i>, a gene specifically expressed in the nervous system with documented functions in neurodevelopment, show hyperactivity and impulsivity phenotypes, which are ameliorated by administering methylphenidate (MPH) or guanfacine (GFC), two pharmacological agents used for ADHD treatment. <i>Fez1</i>-knockout (KO) mice show reduced expression of tyrosine hydroxylase in the midbrain and the brain stem and have reduced levels of dopamine, norepinephrine, or their metabolites in both the nucleus accumbens and the prefrontal cortex. These neurochemical changes in <i>Fez1</i>-KO mice were normalized by MPH or GFC. We propose that <i>Fez1</i>-KO mice can be used as a model to evaluate the role of altered neurodevelopment in the manifestation of ADHD-like behavioral phenotypes, as well as to investigate the neurobiological mechanisms of existing and new pharmacotherapeutic agents for ADHD.
DOI: 10.4225/22/5ae174ca6b132
title: Audiology and Spiritual Care

description: <strong>Fisher Smiley, D., Smiley, H.T., </strong><strong>McCormick Richberg, C.</strong><strong>(2018). Audiology and Spiritual Care. In: Carey, L.B. & Mathisen, B.A. <i>Spiritual Care for Allied Health Practice: A Person-Centered Approach </i>(Chapter 3: pp: 55-65). London: Jessica Kingsley Publishers [ISBN 9781785922206]. DOI</strong><strong>10.4225/22/5ae174ca6b132</strong><br><strong>Summary:</strong> This chapter reviews the current state of spirituality and spiritual care in the practice of audiology. The evidence for a more holistic approach to hearing healthcare is presented, along with case examples to illustrate ways that audiologists can address the spiritual and religious needs of the client. Rationales for the inclusion and exclusion of spiritual care by the audiologist are also presented.<br><br>