DOI: 10.6084/m9.figshare.25040459.v1
title: Machine learning predicts electrospray particle size: Dataset

description: Dataset used in ML-EHD manuscriptThis data was manually curated from other online publications. It included electrosprayed PLGA particle size and the corresponding processing parameters.Pre-trained ModelPlease find our pre-trained model for prediction on https://github.com/FrankWanger/ML_EHDCitationPlease cite the following paper for reference:Wang, F. et al. Machine learning predicts electrospray particle size. Materials & Design 219, 110735 (2022). https://doi.org/10.1016/j.matdes.2022.110735<br>ReferencesThe original data was sourced from the following publications:<br>1. Morais, A. Í. S. et al. Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters. Journal of Functional Biomaterials 11, 4 (2020).<br>2. Narváez-Muñoz, C., Ryzhakov, P. & Pons-Prats, J. Determination of the Operational Parameters for the Manufacturing of Spherical PVP Particles via Electrospray. Polymers 13, 529 (2021).<br>3. 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Lu, J., Hou, R., Yang, Z. & Tang, Z. Development and characterization of drug-loaded biodegradable PLA microcarriers prepared by the electrospraying technique. International Journal of Molecular Medicine 36, 249–254 (2015).<br>9. Chen, J.-M., Liu, K.-C., Yeh, W.-L., Chen, J.-C. & Liu, S.-J. Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies. Int J Mol Sci 21, 1093 (2020).<br>10. Bohr, A., Kristensen, J., Stride, E., Dyas, M. & Edirisinghe, M. Preparation of microspheres containing low solubility drug compound by electrohydrodynamic spraying. International Journal of Pharmaceutics 412, 59–67 (2011).<br>11. Nath, S. D., Son, S., Sadiasa, A., Min, Y. K. & Lee, B. T. Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration. International Journal of Pharmaceutics 443, 87–94 (2013).<br>12. Zarrabi, A., Vossoughi, M., Alemzadeh, I. & Chitsazi, M. R. Monodispersed Polymeric Nanoparticles Fabrication by Electrospray Atomization. International Journal of Polymeric Materials and Polymeric Biomaterials 61, 611–626 (2012).<br>13. Zhao, W. et al. Fabrication and characterization of dual drug-loaded poly (lactic-co-glycolic acid) fiber-microsphere composite scaffolds. International Journal of Polymeric Materials and Polymeric Biomaterials 68, 375–383 (2019).<br>14. Anda, D. A. R. de, Ohannesian, N., Martirosyan, K. S. & Chew, S. A. Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide-loaded PLGA microparticles for the treatment of glioblastoma. Journal of Biomedical Materials Research Part B: Applied Biomaterials 107, 2317–2324 (2019).<br>15. Almería, B., Deng, W., Fahmy, T. M. & Gomez, A. Controlling the morphology of electrospray-generated PLGA microparticles for drug delivery. Journal of Colloid and Interface Science 343, 125–133 (2010).<br>16. Almería, B. & Gomez, A. Electrospray synthesis of monodisperse polymer particles in a broad (60nm–2μm) diameter range: guiding principles and formulation recipes. Journal of Colloid and Interface Science 417, 121–130 (2014).<br>17. Aragón, J., Salerno, S., De Bartolo, L., Irusta, S. & Mendoza, G. Polymeric electrospun scaffolds for bone morphogenetic protein 2 delivery in bone tissue engineering. Journal of Colloid and Interface Science 531, 126–137 (2018).<br>18. Xie, J., Lim, L. K., Phua, Y., Hua, J. & Wang, C.-H. Electrohydrodynamic atomization for biodegradable polymeric particle production. Journal of Colloid and Interface Science 302, 103–112 (2006).<br>19. Ding, L., Lee, T. & Wang, C.-H. Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization. Journal of Controlled Release 102, 395–413 (2005).<br>20. Bohr, A. et al. Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics. J Mater Sci: Mater Med 26, 61 (2015).<br>21. Bohr, A., Kristensen, J., Dyas, M., Edirisinghe, M. & Stride, E. Release profile and characteristics of electrosprayed particles for oral delivery of a practically insoluble drug. J R Soc Interface 9, 2437–2449 (2012).<br>22. Enayati, M., Ahmad, Z., Stride, E. & Edirisinghe, M. Size mapping of electric field-assisted production of polycaprolactone particles. J R Soc Interface 7, S393–S402 (2010).<br>23. Shams, T. et al. Electrosprayed microparticles for intestinal delivery of prednisolone. Journal of The Royal Society Interface 15, 20180491 (2018).<br>24. Hong, Y., Li, Y., Yin, Y., Li, D. & Zou, G. Electrohydrodynamic atomization of quasi-monodisperse drug-loaded spherical/wrinkled microparticles. Journal of Aerosol Science 39, 525–536 (2008).<br>25. Bae, J., Lee, J. & Kim, S. H. Effects of polymer properties on jetting performance of electrohydrodynamic printing. Journal of Applied Polymer Science 134, 45044 (2017).<br>26. Imanparast, F. et al. Preparation, optimization, and characterization of simvastatin nanoparticles by electrospraying: An artificial neural networks study. Journal of Applied Polymer Science 133, (2016).<br>27. Park, C. H. & Lee, J. Electrosprayed polymer particles: Effect of the solvent properties. Journal of Applied Polymer Science 114, 430–437 (2009).<br>28. Wang, L., Zhang, Q., Wang, X., Liu, J. & Yang, J. The preparation and forming mechanism of the red blood cell-shaped microspheres via electrospraying. Journal of Applied Polymer Science 122, 2552–2556 (2011).<br>29. Nguyen, T. T. & Jeong, J. Development of a single-jet electrospray method for producing quercetin-loaded poly (lactic-co-glycolic acid) microspheres with prolonged-release patterns. Journal of Drug Delivery Science and Technology 47, 268–274 (2018).<br>30. Pan, X., Liu, X., Zhuang, X., Liu, Y. & Li, S. Co-delivery of dexamethasone and melatonin by drugs laden PLGA nanoparticles for the treatment of glaucoma. Journal of Drug Delivery Science and Technology 60, 102086 (2020).<br>31. Si, S., Li, H. & Han, X. Sustained release olmesartan medoxomil loaded PLGA nanoparticles with improved oral bioavailability to treat hypertension. Journal of Drug Delivery Science and Technology 55, 101422 (2020).<br>32. Roine, J., Murtomaa, M. & Salonen, J. Influence of parallel nozzle electroencapsulation parameters on microcapsule properties – A case study using the Taguchi robust design method. Journal of Electrostatics 90, 91–105 (2017).