cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7910/dvn/v1rjpf/8qq0sn
title: snk20170228_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859113.v1
title: Supplementary Material for: A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility

description: Breast cancer (BC) predisposition in populations arises from both genetic and nongenetic risk factors. Structural variations such as copy number variations (CNVs) are heritable determinants for disease susceptibility. The primary objectives of this study are (1) to identify CNVs associated with sporadic BC using a genome-wide association study (GWAS) design; (2) to utilize 2 distinct CNV calling algorithms to identify concordant CNVs as a strategy to reduce false positive associations in the hypothesis-generating GWAS discovery phase, and (3) to identify potential candidate CNVs for follow-up replication studies. We used Affymetrix SNP Array 6.0 data profiled on Caucasian subjects (422 cases/348 controls) to call CNVs using algorithms implemented in Nexus Copy Number and Partek Genomics Suite software. Nexus algorithm identified CNVs associated with BC (731 autosomal CNVs with &gt;5% frequency in the total sample and Q &lt; 0.05). Thirteen CNVs were identified when Partek algorithm-called CNVs were overlapped with Nexus-identified CNVs; these CNVs showed concordances for frequency, effect size, and direction. Coding genes present within BC-associated CNVs were known to play a role in disease etiology and prognosis. Long noncoding RNAs identified within CNVs showed tissue-specific expression, indicating potential functional relevance of the findings. The identified candidate CNVs warrant independent replication.
DOI: 10.7910/dvn/v1rjpf/4clgeb
title: snk20170302_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859077
title: Supplementary Material for: Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity

description: Iron deficiency (ID), with and without anemia, affects an estimated 2 billion people worldwide. ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits in hippocampus-mediated learning and memory. Neonatal rats with fetal/neonatal ID anemia (IDA) have shorter hippocampal CA1 apical dendrites with disorganized branching. ID-induced dendritic structural abnormalities persist into adulthood despite normalization of the iron status. However, the specific developmental effects of neuronal iron loss on hippocampal neuron dendrite growth and branching are unknown. Embryonic hippocampal neuron cultures were chronically treated with deferoxamine (DFO, an iron chelator) beginning at 3 days in vitro (DIV). Levels of mRNA for <i>Tfr1</i> and <i>Slc11a2,</i>iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models. DFO treatment decreased mRNA levels for genes indexing dendritic and synaptic development (i.e. <i>BdnfVI,</i><i>Camk2a,</i><i>Vamp1,</i><i>Psd95,</i><i>Cfl1, Pfn1,</i><i>Pfn2, and Gda</i>) and mitochondrial function (i.e. <i>Ucp2,</i><i>Pink1,</i> and <i>Cox6a1</i>). At 18DIV, DFO reduced key aspects of energy metabolism including basal respiration, maximal respiration, spare respiratory capacity, ATP production, and glycolytic rate, capacity, and reserve. Sholl analysis revealed a significant decrease in distal dendritic complexity in DFO-treated neurons at both 11DIV and 18DIV. At 11DIV, the length of primary dendrites and the number and length of branches in DFO-treated neurons were reduced. By 18DIV, partial recovery of the dendritic branch number in DFO-treated neurons was counteracted by a significant reduction in the number and length of primary dendrites and the length of branches. Our findings suggest that early neuronal iron loss, at least partially driven through altered mitochondrial function and neuronal energy metabolism, is responsible for the effects of fetal/neonatal ID and IDA on hippocampal neuron dendritic and synaptic maturation. Impairments in these neurodevelopmental processes likely underlie the negative impact of early life ID and IDA on hippocampus-mediated learning and memory.
DOI: 10.7910/dvn/v1rjpf/z9xo7n
title: snk20170927_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859077.v1
title: Supplementary Material for: Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity

description: Iron deficiency (ID), with and without anemia, affects an estimated 2 billion people worldwide. ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits in hippocampus-mediated learning and memory. Neonatal rats with fetal/neonatal ID anemia (IDA) have shorter hippocampal CA1 apical dendrites with disorganized branching. ID-induced dendritic structural abnormalities persist into adulthood despite normalization of the iron status. However, the specific developmental effects of neuronal iron loss on hippocampal neuron dendrite growth and branching are unknown. Embryonic hippocampal neuron cultures were chronically treated with deferoxamine (DFO, an iron chelator) beginning at 3 days in vitro (DIV). Levels of mRNA for <i>Tfr1</i> and <i>Slc11a2,</i>iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models. DFO treatment decreased mRNA levels for genes indexing dendritic and synaptic development (i.e. <i>BdnfVI,</i><i>Camk2a,</i><i>Vamp1,</i><i>Psd95,</i><i>Cfl1, Pfn1,</i><i>Pfn2, and Gda</i>) and mitochondrial function (i.e. <i>Ucp2,</i><i>Pink1,</i> and <i>Cox6a1</i>). At 18DIV, DFO reduced key aspects of energy metabolism including basal respiration, maximal respiration, spare respiratory capacity, ATP production, and glycolytic rate, capacity, and reserve. Sholl analysis revealed a significant decrease in distal dendritic complexity in DFO-treated neurons at both 11DIV and 18DIV. At 11DIV, the length of primary dendrites and the number and length of branches in DFO-treated neurons were reduced. By 18DIV, partial recovery of the dendritic branch number in DFO-treated neurons was counteracted by a significant reduction in the number and length of primary dendrites and the length of branches. Our findings suggest that early neuronal iron loss, at least partially driven through altered mitochondrial function and neuronal energy metabolism, is responsible for the effects of fetal/neonatal ID and IDA on hippocampal neuron dendritic and synaptic maturation. Impairments in these neurodevelopmental processes likely underlie the negative impact of early life ID and IDA on hippocampus-mediated learning and memory.
DOI: 10.7910/dvn/v1rjpf/xzxtnf
title: snk20171111_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/nwcxy2
title: snk20170803_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/gypu6q
title: mea20160415_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859083.v3
title: Supplemental Figures for Longitudinal Evaluation of Anhedonia as a Mediator of Fear of Positive Evaluation and Other Depressive Symptoms

description: Supplemental figures as part of a manuscript entitled "Longitudinal Evaluation of Anhedonia as a Mediator of Fear of Positive Evaluation and Other Depressive Symptoms."
DOI: 10.7910/dvn/v1rjpf/rrnwvt
title: mea20160506_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ogmyqw
title: mea20150515_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/djdvl8
title: mea20161020_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ynslob
title: mea20160402_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/3qtx1n
title: mea20160416_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859053
title: Associations of plasma lipidomic profile with insulin sensitivity indices-supplemental material

description: Supplemental material to article “Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology” by Kopprasch et al., which includes: S1 Table: Description of insulin sensitivity and resistance indices S2 Table: Internal standards used for lipidomics of blood plasma lipids. Description of names and Abbreviations of lipid classes S3 Table: Overview of statistical test results revealing distinct plasma concentrations of lipid species in NGT, IGT, and T2D individuals S4 Table: Overview of correlations of lipid species with different insulin sensitivity indices
DOI: 10.7910/dvn/v1rjpf/d1rjtq
title: mea20160616_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/cwheik
title: mea20150222_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859053.v1
title: Supplemental Tables

description: Supplemental material to article “Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology” by Kopprasch et al., which includes: S1 Table: Description of insulin sensitivity and resistance indices S2 Table: Internal standards used for lipidomics of blood plasma lipids. Description of names and Abbreviations of lipid classes S3 Table: Overview of statistical test results revealing distinct plasma concentrations of lipid species in NGT, IGT, and T2D individuals S4 Table: Overview of correlations of lipid species with different insulin sensitivity indices
DOI: 10.7910/dvn/v1rjpf/kce1il
title: mea20150412_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859023
title: Northumbria University RCUK OA Year 3

description: Northumbria University's report on usage of the RCUK Open Access block grant, and compliance with the RCUK Open Access policy.<br>Publication data was gathered from Northumbria Research Link, the University's Open Access research repository. Information about article processing charges is recorded through the year in the Jisc APC template. Further information on research funding was obtained through reports extracted from the Agresso finance system.
DOI: 10.7910/dvn/v1rjpf/zlupxm
title: mea20150104_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859023.v1
title: Northumbria University RCUK OA Year 3

description: Northumbria University's report on usage of the RCUK Open Access block grant, and compliance with the RCUK Open Access policy.<br>Publication data was gathered from Northumbria Research Link, the University's Open Access research repository. Information about article processing charges is recorded through the year in the Jisc APC template. Further information on research funding was obtained through reports extracted from the Agresso finance system.
DOI: 10.7910/dvn/v1rjpf/uqfw2c
title: mea20151112_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859017
title: Petrogenesis and metallogenic potential of the Jurassic porphyries in the northwest Zhejiang Province, South China: insights from SHRIMP zircon geochronology, geochemistry, and Sr–Nd–Hf isotopes of the Huangbaikeng ore-bearing porphyries

description: The northwest Zhejiang Province is a key domain for providing deep insight into the crust–mantle interaction and tectonic evolution of the South China block. In this paper, we collect geochemical, geochronological, and isotopic data of the Jurassic porphyries in this region, and investigated the Huangbaikeng ore-bearing porphyry in the Tongcun Mo–Cu deposit, using it as an example to uncover the porphyry petrogenesis and evaluate their metallogenic potential. Two varieties of the Huangbaikeng porphyry were distinguished: the medium- to coarse-grained type and medium- to fine-grained type. Zircon Sensitive High-Resolution Ion Microprobe U–Pb dating indicates that they were emplaced at 161.8 ± 2.8 and 162.7 ± 3.5 Ma, respectively, which are consistent with the molybdenite Re–Os ages of 163.9–161.8 Ma. The inherited zircons age spectrum significantly recorded a series of geological events, for example, assembly and breakup of the Columbia and Rodinia supercontinent, and the Triassic collision of Yangtze and North China blocks. Whole rock Sr–Nd and Jurassic zircon Hf isotopic data yield mostly negative <i>ε</i><sub>Hf</sub>(<i>t</i>) values (0.5 to −8.4) and <i>ε</i><sub>Nd</sub>(<i>t</i>) values (−0.79 to −4.82). Besides the Huangbaikeng porphyry, all the Jurassic porphyries in the northwest Zhejiang Province have a wide range of SiO<sub>2</sub> contents (76.78–60.91 wt.%). They do not contain typical aluminous minerals (e.g. cordierite and garnet), and are mainly metaluminous to weakly peraluminous with high Na<sub>2</sub>O, low FeO<sup>T</sup>/MgO, and Zr + Nb + Ce + Y concentrations in composition. They thus fit the I-type granite definition. Some major and trace elements show strong correlations with SiO<sub>2</sub>, possibly indicating extensive fractional crystallization during their magma evolution. Tectonic discriminations imply that these plutons were likely formed in a volcanic arc regime possibly related to subduction of the Palaeo-Pacific plate. Sr–Nd–Hf isotopic data suggest a mixed source of the Mesoproterozoic crust and 30–50% mantle components. Compared with the adjacent Dexing Cu-bearing porphyies, which have more positive <i>ε</i><sub>Hf</sub>(<i>t</i>) and <i>ε</i><sub>Nd</sub>(<i>t</i>) values with more significant mantle components (55–70%), the Jurassic porphyries in the northwest Zhejiang Province probably lack metallogenic potential to form a giant porphyry copper deposit as Dexing.
DOI: 10.7910/dvn/v1rjpf/hllq1r
title: mea20160117_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3859017.v1
title: Petrogenesis and metallogenic potential of the Jurassic porphyries in the northwest Zhejiang Province, South China: insights from SHRIMP zircon geochronology, geochemistry, and Sr–Nd–Hf isotopes of the Huangbaikeng ore-bearing porphyries

description: The northwest Zhejiang Province is a key domain for providing deep insight into the crust–mantle interaction and tectonic evolution of the South China block. In this paper, we collect geochemical, geochronological, and isotopic data of the Jurassic porphyries in this region, and investigated the Huangbaikeng ore-bearing porphyry in the Tongcun Mo–Cu deposit, using it as an example to uncover the porphyry petrogenesis and evaluate their metallogenic potential. Two varieties of the Huangbaikeng porphyry were distinguished: the medium- to coarse-grained type and medium- to fine-grained type. Zircon Sensitive High-Resolution Ion Microprobe U–Pb dating indicates that they were emplaced at 161.8 ± 2.8 and 162.7 ± 3.5 Ma, respectively, which are consistent with the molybdenite Re–Os ages of 163.9–161.8 Ma. The inherited zircons age spectrum significantly recorded a series of geological events, for example, assembly and breakup of the Columbia and Rodinia supercontinent, and the Triassic collision of Yangtze and North China blocks. Whole rock Sr–Nd and Jurassic zircon Hf isotopic data yield mostly negative <i>ε</i><sub>Hf</sub>(<i>t</i>) values (0.5 to −8.4) and <i>ε</i><sub>Nd</sub>(<i>t</i>) values (−0.79 to −4.82). Besides the Huangbaikeng porphyry, all the Jurassic porphyries in the northwest Zhejiang Province have a wide range of SiO<sub>2</sub> contents (76.78–60.91 wt.%). They do not contain typical aluminous minerals (e.g. cordierite and garnet), and are mainly metaluminous to weakly peraluminous with high Na<sub>2</sub>O, low FeO<sup>T</sup>/MgO, and Zr + Nb + Ce + Y concentrations in composition. They thus fit the I-type granite definition. Some major and trace elements show strong correlations with SiO<sub>2</sub>, possibly indicating extensive fractional crystallization during their magma evolution. Tectonic discriminations imply that these plutons were likely formed in a volcanic arc regime possibly related to subduction of the Palaeo-Pacific plate. Sr–Nd–Hf isotopic data suggest a mixed source of the Mesoproterozoic crust and 30–50% mantle components. Compared with the adjacent Dexing Cu-bearing porphyies, which have more positive <i>ε</i><sub>Hf</sub>(<i>t</i>) and <i>ε</i><sub>Nd</sub>(<i>t</i>) values with more significant mantle components (55–70%), the Jurassic porphyries in the northwest Zhejiang Province probably lack metallogenic potential to form a giant porphyry copper deposit as Dexing.
DOI: 10.7910/dvn/v1rjpf/r9jyqv
title: mea20151114_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/92cskw
title: mea20161225_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/oc37gu
title: mea20150720_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858894
title: data

description: trajectories
DOI: 10.7910/dvn/v1rjpf/cvlwwj
title: mea20151212_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858894.v1
title: data

description: trajectories
DOI: 10.6084/m9.figshare.3858873
title: Cognitive Work Analysis of Two Data Codification Domains

description: Online supplemental material for Cognitive Work Analysis of data codification domains.
DOI: 10.6084/m9.figshare.3858876
title: Associations of plasma lipidomic profile with insulin sensitivity indices-data used for figures 1-3

description: Supplemental material to article “Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology” by Kopprasch et al., which includes data used for figures 1-3.
DOI: 10.7910/dvn/v1rjpf/vxsqn8
title: mea20160512_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/kjmrsy
title: mea20160702_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/tirex3
title: mea20150426_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858873.v1
title: CWA of Data Codification Domains

description: Online supplemental material for Cognitive Work Analysis of data codification domains.
DOI: 10.7910/dvn/v1rjpf/o9umeo
title: mea20160721_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/l5hnrh
title: mea20150625_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/ivw3vy
title: mea20150401_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/vcduvs
title: mea20160115_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/xed0by
title: mea20150503_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858804
title: The role of mobility in Saharan archaeological research (1960-present)

description: Mobility is a key theme in Saharan archaeology. From early human dispersal to the spread of the ‘Neolithic’ up to trade in the historical period, the Saharan regions have been crossed throughout the ages by people, artefacts and ideas on a uniquely large scale. In this area, archaeological research has evolved over time, but climatic and environmental variability has played a major role in the interpretation of past Saharan mobility. This article offers a review of papers on the mobility issue in African archaeology, comparing data from the Sahara and the rest of Africa from 1960 to the present. The main aim is to analyse the development of research on mobility in the Sahara, highlighting its main characteristics and peculiarities and suggesting the adoption of more nuanced approaches to the study of past mobility that may pave the way for ‘alternative’— or simply more refined — reconstructions of cultural trajectories.
DOI: 10.6084/m9.figshare.3858804.v1
title: The role of mobility in Saharan archaeological research (1960-present)

description: Mobility is a key theme in Saharan archaeology. From early human dispersal to the spread of the ‘Neolithic’ up to trade in the historical period, the Saharan regions have been crossed throughout the ages by people, artefacts and ideas on a uniquely large scale. In this area, archaeological research has evolved over time, but climatic and environmental variability has played a major role in the interpretation of past Saharan mobility. This article offers a review of papers on the mobility issue in African archaeology, comparing data from the Sahara and the rest of Africa from 1960 to the present. The main aim is to analyse the development of research on mobility in the Sahara, highlighting its main characteristics and peculiarities and suggesting the adoption of more nuanced approaches to the study of past mobility that may pave the way for ‘alternative’— or simply more refined — reconstructions of cultural trajectories.
DOI: 10.7910/dvn/v1rjpf/ur4psw
title: mea20160328_03.txt.gz

description: :unav
DOI: 10.7910/dvn/v1rjpf/fgsyiw
title: mea20160902_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858795
title: OCC dataset of all the resource embodiments, as of September 24, 2016

description: This archive contains the dump of the OpenCitation Corpus (OCC, http://opencitations.net) dataset about resource embodiments, created regularly every month.<br><br>After unzipping the archive, Disk ARchive (DAR, http://dar.linux.free.fr/, a multi-platform archive tool for managing huge amount of data) is needed for recreating the whole structure. For extracting the DAR archive, please run the command<br><br>dar -x [archive-name]<br><br>Where "[archive-name"] is the name of the DAR file without final package number and extension. E.g.:<br><br>dar -x 2016-09-23-corpus_re<br><br>For further questions, comments, and suggestions please don't hesitate to contact Silvio Peroni at essepuntato@opencitations.net.<br>
DOI: 10.7910/dvn/v1rjpf/torqme
title: mea20151130_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858795.v1
title: OCC dataset of all the resource embodiments, as of September 24, 2016

description: This archive contains the dump of the OpenCitation Corpus (OCC, http://opencitations.net) dataset about resource embodiments, created regularly every month.<br><br>After unzipping the archive, Disk ARchive (DAR, http://dar.linux.free.fr/, a multi-platform archive tool for managing huge amount of data) is needed for recreating the whole structure. For extracting the DAR archive, please run the command<br><br>dar -x [archive-name]<br><br>Where "[archive-name"] is the name of the DAR file without final package number and extension. E.g.:<br><br>dar -x 2016-09-23-corpus_re<br><br>For further questions, comments, and suggestions please don't hesitate to contact Silvio Peroni at essepuntato@opencitations.net.<br>
DOI: 10.6084/m9.figshare.3858789
title: OCC provenance data of all the resource embodiments, as of September 24, 2016

description: This archive contains the dump of the OpenCitation Corpus (OCC, http://opencitations.net) provenance data about resource embodiments, created regularly every month.<br><br>After unzipping the archive, Disk ARchive (DAR, http://dar.linux.free.fr/, a multi-platform archive tool for managing huge amount of data) is needed for recreating the whole structure. For extracting the DAR archive, please run the command<br><br>dar -x [archive-name]<br><br>Where "[archive-name"] is the name of the DAR file without final package number and extension. E.g.:<br><br>dar -x 2016-09-23-corpus_re<br><br>For further questions, comments, and suggestions please don't hesitate to contact Silvio Peroni at essepuntato@opencitations.net.
DOI: 10.7910/dvn/v1rjpf/vjcmhh
title: mea20151210_03.txt.gz

description: :unav
DOI: 10.6084/m9.figshare.3858786
title: OCC dataset of all the responsible agents, as of September 24, 2016

description: This archive contains the dump of the OpenCitation Corpus (OCC, http://opencitations.net) dataset about responsible agents, created regularly every month.<br><br>After unzipping the archive, Disk ARchive (DAR, http://dar.linux.free.fr/, a multi-platform archive tool for managing huge amount of data) is needed for recreating the whole structure. For extracting the DAR archive, please run the command<br><br>dar -x [archive-name]<br><br>Where "[archive-name"] is the name of the DAR file without final package number and extension. E.g.:<br><br>dar -x 2016-09-23-corpus_re<br><br>For further questions, comments, and suggestions please don't hesitate to contact Silvio Peroni at essepuntato@opencitations.net.