cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5517/ccdc.csd.cc2mnvlr
title: CCDC 2433115: Experimental Crystal Structure Determination

description: Related Article: Jaroslaw Mazurek|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/l6x-t6g-kpl
title: Fumana arabica (L.) Spach

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/n06-15p-lsg
title: Fumana arabica (L.) Spach

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5517/ccdc.csd.cc2mpdnd
title: CCDC 2433644: Experimental Crystal Structure Determination

description: Related Article: Asit kumar pradhan|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/rzh-eac-as4
title: Bromus arvensis L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/zqw-9zk-csl
title: Erodium malacoides (L.) L'Hér.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5517/ccdc.csd.cc2mpdpf
title: CCDC 2433645: Experimental Crystal Structure Determination

description: Related Article: Asit kumar pradhan|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2mpdtk
title: CCDC 2433649: Experimental Crystal Structure Determination

description: Related Article: Dongjing Hong|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.29459999
title: Causal associations between neuroinflammation-related genes and intracerebral hemorrhage: an integrated study of Mendelian Randomization and gene functional analysis

description: Intracerebral hemorrhage (ICH) is a life-threatening stroke subtype where neuroinflammation plays a crucial role. However, the genetic basis for neuroinflammation in ICH remains unclear. This study used Mendelian Randomization (MR) to investigate the causal impact of neuroinflammation-related genes on ICH risk. A two-sample MR analysis was conducted using genetic variants from large-scale genome-wide association studies (GWAS). The primary analytical methods included the inverse variance weighted (IVW) approach, supplemented by MR-Egger regression and the weighted median method. Protein-protein interaction (PPI) network analysis, Gene Ontology (GO) enrichment analysis, and Gene Set Enrichment Analysis (GSEA) were employed to explore the biological mechanisms underlying these associations. Elevated expression of the CHUK gene was significantly associated with increased ICH risk (OR = 1.17, 95% CI 1.02–1.35, <i>p</i> = 0.0245 in the Ebi-ICH dataset; OR = 1.25, 95% CI 1.03–1.52, <i>p</i> = 0.0252 in the Finn-ICH dataset). Similarly, the CTLA4 gene showed a strong association with ICH (OR = 1.29, 95% CI 1.10–1.52, <i>p</i> &lt; 0.01 in the Ebi-ICH dataset; OR = 1.23, 95% CI 1.02–1.47, <i>p</i> = 0.0264 in the Finn-ICH dataset). These results suggest that these genes contribute to ICH through mechanisms involving the NF-κB signaling pathway and immune regulation. The findings reveal a significant genetic influence of CHUK and CTLA4 on ICH risk, provide potential targets for future therapeutic interventions, which could lead to the development of more effective treatment strategies for ICH. This study integrates Mendelian randomization analysis with gene functional characterization to identify causal links between neuroinflammation-related genes and intracerebral hemorrhage (ICH). CHUK and CTLA4 were highlighted as key risk genes, influencing ICH through immune regulation and the NF-κB signaling pathway. These findings offer potential therapeutic targets for mitigating neuroinflammation in ICH.
DOI: 10.3535/5ma-7bv-3cb
title: Erodium malacoides (L.) L'Hér.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ymc-7ys-95w
title: Descurainia sophia (L.) Webb ex Prantl

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.6084/m9.figshare.29459999.v2
title: Causal associations between neuroinflammation-related genes and intracerebral hemorrhage: an integrated study of Mendelian Randomization and gene functional analysis

description: Intracerebral hemorrhage (ICH) is a life-threatening stroke subtype where neuroinflammation plays a crucial role. However, the genetic basis for neuroinflammation in ICH remains unclear. This study used Mendelian Randomization (MR) to investigate the causal impact of neuroinflammation-related genes on ICH risk. A two-sample MR analysis was conducted using genetic variants from large-scale genome-wide association studies (GWAS). The primary analytical methods included the inverse variance weighted (IVW) approach, supplemented by MR-Egger regression and the weighted median method. Protein-protein interaction (PPI) network analysis, Gene Ontology (GO) enrichment analysis, and Gene Set Enrichment Analysis (GSEA) were employed to explore the biological mechanisms underlying these associations. Elevated expression of the CHUK gene was significantly associated with increased ICH risk (OR = 1.17, 95% CI 1.02–1.35, <i>p</i> = 0.0245 in the Ebi-ICH dataset; OR = 1.25, 95% CI 1.03–1.52, <i>p</i> = 0.0252 in the Finn-ICH dataset). Similarly, the CTLA4 gene showed a strong association with ICH (OR = 1.29, 95% CI 1.10–1.52, <i>p</i> &lt; 0.01 in the Ebi-ICH dataset; OR = 1.23, 95% CI 1.02–1.47, <i>p</i> = 0.0264 in the Finn-ICH dataset). These results suggest that these genes contribute to ICH through mechanisms involving the NF-κB signaling pathway and immune regulation. The findings reveal a significant genetic influence of CHUK and CTLA4 on ICH risk, provide potential targets for future therapeutic interventions, which could lead to the development of more effective treatment strategies for ICH. This study integrates Mendelian randomization analysis with gene functional characterization to identify causal links between neuroinflammation-related genes and intracerebral hemorrhage (ICH). CHUK and CTLA4 were highlighted as key risk genes, influencing ICH through immune regulation and the NF-κB signaling pathway. These findings offer potential therapeutic targets for mitigating neuroinflammation in ICH.
DOI: 10.6084/m9.figshare.29468186
title: Transcriptomics insight into occupational exposure to engineered nanoparticles

description: To investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years). Whole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring. Following PM0.1 exposure, a significant decrease in the expression of <i>DDIT4</i> and <i>FKBP5</i>, genes involved in the stress response, was detected in exposed workers. In the Machining group, the <i>DDIT4</i> expression correlated with the exposure dose. Increased levels of miR30-d-5p and miR-3613-5p (both involved in carcinogenesis) in welders were associated with the NP exposure dose, highlighting their potential suitability as inhalation exposure markers. The results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended. This is a follow-up study to our previous research that examined the acute effects of occupational inhalation exposure to nanoparticles (NPs) in females without a previous exposure history. This time, we reexamined the impacts of acute exposure in a group of 18 male workers, including welders and nanocomposite machinists with a long-term previous exposure history at the transcriptomic level. Whole genome transcriptomics studies the complete set of RNA molecules, or transcripts, produced in a cell or organism at a specific time. The analysis allows us to understand which genes are active/inactive, how they are regulated, and how they contribute to various biological processes or diseases. We looked at changes in mRNA and miRNA (types of RNA) from blood samples taken before and after workers were exposed to dust and fumes during machining and welding. We also monitored the exposure doses. The results suggest that inhaled NPs may present an occupational hazard to human health. The transcriptomic analysis shows that exposure to welding fumes and nanocomposite dust from machining affects the immune system and alters cancer-related pathways. Our research helps to understand NP exposure effects and may contribute to minimizing the negative health consequences of their inhalation.
DOI: 10.6084/m9.figshare.29468186.v1
title: Transcriptomics insight into occupational exposure to engineered nanoparticles

description: To investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years). Whole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring. Following PM0.1 exposure, a significant decrease in the expression of <i>DDIT4</i> and <i>FKBP5</i>, genes involved in the stress response, was detected in exposed workers. In the Machining group, the <i>DDIT4</i> expression correlated with the exposure dose. Increased levels of miR30-d-5p and miR-3613-5p (both involved in carcinogenesis) in welders were associated with the NP exposure dose, highlighting their potential suitability as inhalation exposure markers. The results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended. This is a follow-up study to our previous research that examined the acute effects of occupational inhalation exposure to nanoparticles (NPs) in females without a previous exposure history. This time, we reexamined the impacts of acute exposure in a group of 18 male workers, including welders and nanocomposite machinists with a long-term previous exposure history at the transcriptomic level. Whole genome transcriptomics studies the complete set of RNA molecules, or transcripts, produced in a cell or organism at a specific time. The analysis allows us to understand which genes are active/inactive, how they are regulated, and how they contribute to various biological processes or diseases. We looked at changes in mRNA and miRNA (types of RNA) from blood samples taken before and after workers were exposed to dust and fumes during machining and welding. We also monitored the exposure doses. The results suggest that inhaled NPs may present an occupational hazard to human health. The transcriptomic analysis shows that exposure to welding fumes and nanocomposite dust from machining affects the immune system and alters cancer-related pathways. Our research helps to understand NP exposure effects and may contribute to minimizing the negative health consequences of their inhalation.
DOI: 10.6084/m9.figshare.29468271
title: Near-infrared II nanomaterials for hypoxic TME diagnosis and therapy

description: Hypoxic tumor microenvironments (TME) drive cancer aggression and therapy resistance, necessitating precise diagnostic and therapeutic strategies. Near-Infrared II (NIR-II) nanomaterials have emerged as transformative tools for addressing hypoxic TME challenges, leveraging deeper tissue penetration, minimal scattering, and reduced autofluorescence. This review systematically summarizes the recent advancements in NIR-II nanomaterials, focusing on their applications in imaging and therapy for hypoxic tumors. NIR-II-based imaging techniques, including fluorescence, photoacoustic, and multimodal imaging, provide high sensitivity and resolution for detecting hypoxic regions, aiding in early diagnosis and personalized treatment planning. In therapeutic applications, NIR-II materials enhance the efficacy of photothermal therapy, photodynamic therapy, and photo-Fenton therapy, all of which overcome the limitations of traditional therapies in hypoxic areas. The combination of NIR-II materials with other treatment modalities holds promise for more effective cancer treatments. This review also discusses the challenges in the current research landscape, including the preparation, scalability, and clinical translation of NIR-II materials. It highlights the need for continued innovation to optimize these materials for broader clinical applications. Overall, NIR-II nanomaterials represent a significant step forward in addressing the challenges posed by hypoxic tumors, with the potential to revolutionize cancer diagnosis and therapy. NIR-II nanomaterials offer breakthrough potential in hypoxic tumor diagnosis and therapy. With deep tissue imaging, reduced scattering, and hypoxia-targeted treatments (photothermal, photodynamic, photo-Fenton), they combat treatment resistance. Promising for precision medicine!
DOI: 10.6084/m9.figshare.29468271.v1
title: Near-infrared II nanomaterials for hypoxic TME diagnosis and therapy

description: Hypoxic tumor microenvironments (TME) drive cancer aggression and therapy resistance, necessitating precise diagnostic and therapeutic strategies. Near-Infrared II (NIR-II) nanomaterials have emerged as transformative tools for addressing hypoxic TME challenges, leveraging deeper tissue penetration, minimal scattering, and reduced autofluorescence. This review systematically summarizes the recent advancements in NIR-II nanomaterials, focusing on their applications in imaging and therapy for hypoxic tumors. NIR-II-based imaging techniques, including fluorescence, photoacoustic, and multimodal imaging, provide high sensitivity and resolution for detecting hypoxic regions, aiding in early diagnosis and personalized treatment planning. In therapeutic applications, NIR-II materials enhance the efficacy of photothermal therapy, photodynamic therapy, and photo-Fenton therapy, all of which overcome the limitations of traditional therapies in hypoxic areas. The combination of NIR-II materials with other treatment modalities holds promise for more effective cancer treatments. This review also discusses the challenges in the current research landscape, including the preparation, scalability, and clinical translation of NIR-II materials. It highlights the need for continued innovation to optimize these materials for broader clinical applications. Overall, NIR-II nanomaterials represent a significant step forward in addressing the challenges posed by hypoxic tumors, with the potential to revolutionize cancer diagnosis and therapy. NIR-II nanomaterials offer breakthrough potential in hypoxic tumor diagnosis and therapy. With deep tissue imaging, reduced scattering, and hypoxia-targeted treatments (photothermal, photodynamic, photo-Fenton), they combat treatment resistance. Promising for precision medicine!
DOI: 10.3535/5a9-hzr-dbm
title: Lotus hirsutus L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/c5z-9ql-3pq
title: Erodium malacoides (L.) L'Hér.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5517/ccdc.csd.cc2mpcxm
title: CCDC 2433621: Experimental Crystal Structure Determination

description: Related Article: L Li|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.29459999.v1
title: Causal Associations Between Neuroinflammation-Related Genes and Intracerebral Hemorrhage: An Integrated Study of Mendelian Randomization and Gene Functional Analysis

description: Intracerebral hemorrhage (ICH) is a life-threatening stroke subtype where neuroinflammation plays a crucial role. However, the genetic basis for neuroinflammation in ICH remains unclear. This study used Mendelian Randomization (MR) to investigate the causal impact of neuroinflammation-related genes on ICH risk. A two-sample MR analysis was conducted using genetic variants from large-scale genome-wide association studies (GWAS). The primary analytical methods included the inverse variance weighted (IVW) approach, supplemented by MR-Egger regression and the weighted median method. Protein-protein interaction (PPI) network analysis, Gene Ontology (GO) enrichment analysis, and Gene Set Enrichment Analysis (GSEA) were employed to explore the biological mechanisms underlying these associations. Elevated expression of the CHUK gene was significantly associated with increased ICH risk (OR = 1.17, 95% CI 1.02–1.35, p = 0.0245 in the Ebi-ICH dataset; OR = 1.25, 95% CI 1.03–1.52, p = 0.0252 in the Finn-ICH dataset). Similarly, the CTLA4 gene showed a strong association with ICH (OR = 1.29, 95% CI 1.10–1.52, p &lt; 0.01 in the Ebi-ICH dataset; OR = 1.23, 95% CI 1.02–1.47, p = 0.0264 in the Finn-ICH dataset). These results suggest that these genes contribute to ICH through mechanisms involving the NF-κB signaling pathway and immune regulation. The findings reveal a significant genetic influence of CHUK and CTLA4 on ICH risk, provide potential targets for future therapeutic interventions, which could lead to the development of more effective treatment strategies for ICH.
DOI: 10.6084/m9.figshare.29484005
title: Harnessing multifunctional HBc virus-like particles for safe and effective delivery of melittin in cancer therapy

description: To overcome the clinical limitations of melittin, a potent anticancer host defense peptide, by developing a multifunctional, virus-like particle (VLP)-based delivery system that enhances tumor targeting, immune activation, and therapeutic safety. A nanoplatform based on hepatitis B core virus-like particles (HBc VLPs) was engineered to encapsulate melittin. The design incorporated RGD peptides for improved tumor specificity, Tuftsin to promote phagocytosis, and M2pep to selectively target immunosuppressive M2 macrophages. An MMP-2-cleavable linker enabled tumor-specific activation, allowing controlled release of RGD-melittin and immune-stimulating peptides. Antitumor efficacy was evaluated in subcutaneous melanoma and lung metastasis mouse models. The multifunctional HBc VLP platform effectively protected melittin from enzymatic degradation, reduced off-target cytotoxicity, and improved tumor selectivity. It demonstrated significant tumor suppression and immune modulation in both melanoma and lung metastasis models, outperforming free melittin treatment. This study presents a versatile, multifunctional VLP-based nanoplatform for the safe and effective delivery of melittin, offering enhanced tumor targeting and immune activation. The findings support its potential for clinical translation as a novel cancer immunotherapy strategy.
DOI: 10.6084/m9.figshare.29484005.v1
title: Harnessing multifunctional HBc virus-like particles for safe and effective delivery of melittin in cancer therapy

description: To overcome the clinical limitations of melittin, a potent anticancer host defense peptide, by developing a multifunctional, virus-like particle (VLP)-based delivery system that enhances tumor targeting, immune activation, and therapeutic safety. A nanoplatform based on hepatitis B core virus-like particles (HBc VLPs) was engineered to encapsulate melittin. The design incorporated RGD peptides for improved tumor specificity, Tuftsin to promote phagocytosis, and M2pep to selectively target immunosuppressive M2 macrophages. An MMP-2-cleavable linker enabled tumor-specific activation, allowing controlled release of RGD-melittin and immune-stimulating peptides. Antitumor efficacy was evaluated in subcutaneous melanoma and lung metastasis mouse models. The multifunctional HBc VLP platform effectively protected melittin from enzymatic degradation, reduced off-target cytotoxicity, and improved tumor selectivity. It demonstrated significant tumor suppression and immune modulation in both melanoma and lung metastasis models, outperforming free melittin treatment. This study presents a versatile, multifunctional VLP-based nanoplatform for the safe and effective delivery of melittin, offering enhanced tumor targeting and immune activation. The findings support its potential for clinical translation as a novel cancer immunotherapy strategy.
DOI: 10.3535/9d2-wdw-12t
title: Geranium molle L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/zzd-jtg-sxe
title: Erodium malacoides (L.) L'Hér.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5517/ccdc.csd.cc2mpqln
title: CCDC 2433952: Experimental Crystal Structure Determination

description: Related Article: Tianyu Zhu|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/el4-thb-3bb
title: Geranium molle L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.5517/ccdc.csd.cc2mptrx
title: CCDC 2434050: Experimental Crystal Structure Determination

description: Related Article: Liu Peng|2025|CSD Communication|||
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.3535/8bk-2eg-p4b
title: Erodium absinthoides Willd.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.