cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.23578713
title: Supplementary Material for: CureGN-Diabetes Study: Rationale, Design, and Methods of a Prospective Observational Study of Glomerular Disease Patients with Diabetes

description: Glomerular diseases (GDs) represent the third leading cause of end stage kidney disease (ESKD) in the U.S.. Diabetes was excluded from the CureGN Study, an NIH/NIDDK-sponsored observational cohort study of four leading primary GDs: IgA nephropathy (IgAN), membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), and minimal change disease (MCD). CureGN-Diabetes, an ancillary study to CureGN, seeks to understand how diabetes influences the diagnosis, treatment, and outcomes of GD. It is a multicenter, prospective cohort study, targeting an enrollment of 300 adults with prevalent type 1 or type 2 diabetes and MCD, FSGS, MN, or IgAN, with first kidney biopsy obtained within 5 years of enrollment in 80% (20% allowed if biopsy after 2010). CureGN and Transformative Research In DiabEtic NephropaThy (TRIDENT) provide comparator cohorts. Retrospective and prospective clinical data and patient reported outcomes are obtained. Blood and urine specimens are collected at study visits annually. Kidney biopsy reports and digital images are obtained, and standardized pathologic evaluations performed. Light microscopy images are uploaded to the NIH pathology repository. Outcomes include relapse and remission rates, changes in proteinuria and estimated glomerular filtration rate, infections, cardiovascular events, malignancy, ESKD and death. Multiple analytical approaches will be used leveraging the baseline and longitudinal data to compare disease presentation and progression across subgroups of interest. With 300 patients and an average of 3 years of follow-up, the study has 80% power to detect a HR of 1.4-1.8 for time to complete remission of proteinuria, a rate ratio for hospitalizations of 1.18-1.56 and difference in eGFR slope of 6.0-8.6 ml/min/year between two groups of 300 participants each. CureGN-Diabetes will enhance our understanding of diabetes as a modifying factor of the pathology and outcomes of glomerular diseases and support studies to identify disease mechanisms and improve patient outcomes in this understudied patient population.
DOI: 10.6084/m9.figshare.23905143
title: Supplementary Material for: Geometric versus hemodynamic indexes for rupture-destined aneurysms: a retrospective cohort and a repeated-measures study

description: Introduction: A proper stratification of intracranial aneurysms is critical in identifying rupture-destined aneurysms and unruptured intracranial aneurysms. We aimed to determine the utility of geometric and hemodynamic indexes in differentiating two types of aneurysms, and to examine the characteristics of natural evolutionary changes of unruptured aneurysms. Methods: Rupture-destined aneurysm refers to an aneurysm that undergoes subsequent aneurysmal subarachnoid hemorrhage (SAH). On the other hand, an unruptured intracranial aneurysm is characterized by an aneurysm that does not experience rupture during serial time-of-flight magnetic resonance angiography (TOF-MRA). In addition to geometric indexes, signal intensity gradient (SIG), an in-vivo approximated wall shear stress from TOF-MRA, was measured in aneurysms. The difference between the maximum and minimum values of SIG in an aneurysm compared to parent arterial values was designated as the delta-SIG ratio. Results: This study analyzed 20 rupture-destined aneurysms in 20 patients and 45 unruptured intracranial aneurysms in 41 patients with follow-up TOF-MRA. While geometric indexes did not show differences between the two groups, the delta-SIG ratio was higher in the rupture-destined aneurysms (1.5±0.6 vs. 1.1±0.3, P=0.032). The delta-SIG ratio showed a higher area under the receiver operating characteristics curve for SAH than the size ratio (0.72 [95% CI, 0.58–0.87] vs. 0.56 [95% CI, 0.41–0.72], P=0.033). The longitudinal re-examination of TOF-MRA in the unruptured intracranial aneurysms revealed evidence of aneurysmal growth, while concurrently exhibiting hemodynamic stability. Discussion/Conclusion: The delta-SIG ratio showed higher discriminatory results between the two groups compared to geometric indexes. Aneurysmal rupture risk should be assessed by considering both geometric and hemodynamic information. This study was registered on ClinicalTrials.gov (NCT05450939).
DOI: 10.6084/m9.figshare.24125436
title: Supplementary Material for: DNA methylation pattern in somatotroph pituitary neuroendocrine tumors

description: Introduction. Growth hormone secretion by sporadic somatotroph neuroendocrine pituitary tumors (PitNETs) is major cause of acromegaly. These tumors are relatively heterogenous in terms of histopathological and molecular features. Our previous transcriptomic profiling of somatotroph tumors revealed three distinct molecular subtypes. This study was aimed to investigate difference in DNA methylation pattern in subtypes of somatotroph PitNETs and its role in distinctive gene expression. Methods. Genome-wide DNA methylation was investigated in 48 somatotroph PitNETs with EPIC microarrays. Gene expression was assessed with RNAseq. Bisulfite pyrosequencing and qRT-PCR were used for verifying results of DNA methylation and gene expression. Results. Clustering tumor samples based on methylation data reflected the transcriptome-related classification. Subtype 1 tumors are densely granulated without GNAS mutation, characterized by high expression of NR5A1 (SF-1) and GIPR. The expression of both genes is correlated with specific methylation of gene body and promoter. This subtype has lower methylation level of 5’ gene regions and CpG islands than the remaining tumors. Subtype 2 PitNETs are densely granulated, frequently GNAS-mutated while those in subtype 3 are mainly sparsely granulated. Methylation/expression analysis indicates that ~50% genes located in differentially methylated regions are those differentially expressed between tumor subtypes. Correlation analysis revealed DNA methylation-controlled genes including CDKN1B, CCND2, EBF3, CDH4, CDH12, MGMT, STAT5A, PLXND1, PTPRE, MMP16 and genes encoding ion channels and semaphorins. Conclusion. DNA methylation profiling confirmed the existence of three molecular subtypes of somatotroph PitNETs. High expression of NR5A1 and GIPR in subtype 1 tumors is correlated with specific methylation of both genes.
DOI: 10.6084/m9.figshare.24155145
title: Supplementary Material for: Protease-activated receptor 2 controls vascular smooth muscle cell proliferation in cyclic AMP-dependent protein kinase/mitogen-activated protein kinase kinase 1/2-dependent manner

description: Introduction: Cardiovascular disorders are characterized by vascular smooth muscle (VSM) transition from a contractile to proliferative state. Protease-activated receptor 2 (PAR2) involvement in this phenotypic conversion remains unclear. We hypothesized that PAR2 controls VSM cell proliferation in phenotype-dependent manner and through specific protein kinases. Methods: Rat clonal low (PLo; P3-P6) and high passage (PHi; P10-P15) VSM cells were established as respective models of quiescent and proliferative cells, based on reduced PKG-1 and VASP. Western blotting determined expression of cytoskeletal/contractile proteins, PAR2, and select protein kinases. DNA synthesis and cell proliferation were measured 24-72 hours following PAR2 agonism (SLIGRL; 100nM-10μM) with/without PKA (PKI; 10μM), MEK1/2 (PD98059; 10μM), and PI3K (LY294002; 1μM) blockade. Results: PKG-1, VASP, SM22α, calponin, cofilin, and PAR2 were reduced in PHi versus PLo cells. Following PAR2 agonism, DNA synthesis and cell proliferation increased in PLo cells but decreased in PHi cells. Western analyses showed reduced PKA, MEK1/2, and PI3K in PHi versus PLo cells, and kinase blockade revealed PAR2 controls VSM cell proliferation through PKA/MEK1/2. Discussion: Findings highlight PAR2 and PAR2-driven PKA/MEK1/2 in control of VSM cell growth and provide evidence for continued investigation of PAR2 in VSM pathology.
DOI: 10.7925/drs1.duchas_5111285
title: More Local Cures

description: Story collected by a student at Woodpole school (Woodpole, Co. Meath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Siobhán, Bean Uí Chonaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130391
title: Weather-Lore

description: Story collected by Maria Clarke, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133449
title: Severe Weather

description: Story collected by James Gahan, a student at Boulavogue school (Boleyvogue, Co. Wexford) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Énrí Tréinfhear.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938790
title: Homemade Toys

description: Story collected by Anthony Neeson, a student at Tulach Chromán school (Tullycroman, Co. Monaghan) from informant Mr Philip Neeson.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Mrs. Brennan.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111286
title: Valley of the Black Pig

description: Story collected by Kathleen Smyth, a student at Moynalty (C.) school (Moynalty, Co. Meath) from informant G. O' Connor.
description: Teacher name missing.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher #missing.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130394
title: Potato Crop

description: Story collected by Delia Harrington, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133450
title: Famine

description: Story collected by Bridie Doyle, a student at Kilmyshal school (Kilmyshall, Co. Wexford) from informant Mogue Doyle.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher E. Mac Niocláis.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111287
title: Big Moat in Clonabraney

description: Story collected by D.F. O' Sullivan, a student at Ballinlough school (Ballinlough Big, Co. Meath) from informant Tom Keogan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher P. Mac Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938791
title: Homemade Toys

description: Story collected by Teresa Mc Ardle, a student at Tulach Chromán school (Tullycroman, Co. Monaghan) from informant Mrs Mc Ardle.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Mrs. Brennan.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133451
title: Leprechaun

description: Story collected by a student at Marshalstown school (Marshalstown, Co. Wexford) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Seosamh Ó Macháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111290
title: Site of Old Church

description: Story collected by D.F. O' Sullivan, a student at Ballinlough school (Ballinlough Big, Co. Meath) from informant Tom Keogan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher P. Mac Domhnaill.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130396
title: Weather-Lore

description: Story collected by Aggie Gavin, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938793
title: Homemade Toys

description: Story collected by Eileen Dinkin, a student at Tulach Chromán school (Tullycroman, Co. Monaghan) from informant Pat Dinkin.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Mrs. Brennan.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133452
title: Severe Weather

description: Story collected by a student at Marshalstown school (Marshalstown, Co. Wexford) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Seosamh Ó Macháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111292
title: Carrick Dexter

description: Story collected by Charles Murray, a student at Flower Hill school (Flower Hill, Co. Meath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Isabel Mc Quade.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130397
title: Proverbs

description: Story collected by Vera Smith, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938794
title: Homemade Toys

description: Story collected by Dympna Magee, a student at Tulach Chromán school (Tullycroman, Co. Monaghan) from informant Mrs Brigid Magee.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Mrs. Brennan.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133453
title: Local Roads

description: Story collected by a student at Marshalstown school (Marshalstown, Co. Wexford) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Seosamh Ó Macháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938795
title: Homemade Toys

description: Story collected by Leo Magee, a student at Tulach Chromán school (Tullycroman, Co. Monaghan) from informant Mrs Brigid Magee.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Mrs. Brennan.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130399
title: Proverbs

description: Story collected by Mary Jordan, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111293
title: Another Story of Hidden Treasure

description: Story collected by Kathleen Smyth, a student at Moynalty (C.) school (Moynalty, Co. Meath) from informant G. O' Connor.
description: Teacher name missing.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher #missing.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133454
title: Old Schools

description: Story collected by James Gahan, a student at Boulavogue school (Boleyvogue, Co. Wexford) from informant Mr Michael Gahan.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Énrí Tréinfhear.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111295
title: Another Story of Hidden Treasure

description: Story collected by a student at Moynalty (C.) school (Moynalty, Co. Meath) from informant Peter Smyth.
description: Teacher name missing.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher #missing.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938797
title: Candle-Making

description: Story collected by Mary Mac Manus, a student at Losad school (Losset, Co. Monaghan) from informant Patrick Mac Manus.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Herbert Taylor.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130400
title: Proverbs

description: Story collected by Una Clarke, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5111298
title: Herbs Found in the District

description: Story collected by a student at Moynalty (C.) school (Moynalty, Co. Meath) (no informant identified).
description: Teacher name missing.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher #missing.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5130402
title: Riddles

description: Story collected by Esther Mahon, a student at Ballymore (C.) school (Ballymore, Co. Westmeath) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher K. -- Kearney, Mrs Kavanagh.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133455
title: Famine

description: Story collected by Maggie Byrne, a student at Kilmyshal school (Kilmyshall, Co. Wexford) from informant Hugh Byrne.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher E. Mac Niocláis.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_4938798
title: Local Heroes

description: Story collected by Peig Ní Loingsig, a student at Corracharra school (Corracharra, Co. Monaghan) from informant Tomás Ó Dubhthaigh.
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Brian Mac Aodha.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
DOI: 10.7925/drs1.duchas_5133456
title: Herbs

description: Story collected by Nancy Murphy, a student at Marshalstown school (Marshalstown, Co. Wexford) (no informant identified).
description: Collected as part of the Schools' Folklore scheme, 1937-1938, under the supervision of teacher Seosamh Ó Macháin.
description: Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.