cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28238723
title: Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment

description: This study aimed to develop a prognostic model based on extracellular trap-related genes (NETRGs) for patients with cALL. Data from the TARGET-ALL-P2 and TARGET-ALL-P3 cohorts in the Genomic Data Commons database, the transcriptome dataset GSE26713, the single-cell transcriptome dataset GSE130116 from the Gene Expression Omnibus database and 306 NETRGs identified were analysed. Differentially expressed genes (DEGs) were identified from GSE26713 and differentially expressed NETRGs (DE-NETRGs) were obtained by overlapping DEGs with NETRGs. Functional analyses were conducted. Key feature genes were identified through univariate and least absolute shrinkage and selection operator (LASSO) regression. Prognostic genes were determined via multivariate Cox regression analysis, followed by the construction and validation of a risk model and nomogram. Additional analyses included immune profiling, drug sensitivity, functional differences, cell-type-specific expression, enrichment analysis and RT-qPCR. A total of 1,270 DEGs were identified in GSE26713, of which 74 overlapped with NETRGs. Seven prognostic genes were identified using univariate, LASSO and multivariate Cox regression analyses. Survival analysis revealed lower survival rates in the high-risk group. Independent prognostic analysis identified risk scores and primary diagnosis as independent predictors of prognosis. Immune cell profiling showed significant differences in cell populations such as aDCs, eosinophils and Th2 cells between risk groups. Six cell subtypes were annotated, with prognostic genes predominantly expressed in myeloid cells. RT-qPCR revealed that PTAFR, FCGR2A, RETN and CAT were significantly downregulated, while TLR2 and S100A12 were upregulated in cALL. TLR2, PTAFR, FCGR2A, RETN, S100A12 and CAT may serve as potential therapeutic targets.
DOI: 10.6084/m9.figshare.28238723.v1
title: Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment

description: This study aimed to develop a prognostic model based on extracellular trap-related genes (NETRGs) for patients with cALL. Data from the TARGET-ALL-P2 and TARGET-ALL-P3 cohorts in the Genomic Data Commons database, the transcriptome dataset GSE26713, the single-cell transcriptome dataset GSE130116 from the Gene Expression Omnibus database and 306 NETRGs identified were analysed. Differentially expressed genes (DEGs) were identified from GSE26713 and differentially expressed NETRGs (DE-NETRGs) were obtained by overlapping DEGs with NETRGs. Functional analyses were conducted. Key feature genes were identified through univariate and least absolute shrinkage and selection operator (LASSO) regression. Prognostic genes were determined via multivariate Cox regression analysis, followed by the construction and validation of a risk model and nomogram. Additional analyses included immune profiling, drug sensitivity, functional differences, cell-type-specific expression, enrichment analysis and RT-qPCR. A total of 1,270 DEGs were identified in GSE26713, of which 74 overlapped with NETRGs. Seven prognostic genes were identified using univariate, LASSO and multivariate Cox regression analyses. Survival analysis revealed lower survival rates in the high-risk group. Independent prognostic analysis identified risk scores and primary diagnosis as independent predictors of prognosis. Immune cell profiling showed significant differences in cell populations such as aDCs, eosinophils and Th2 cells between risk groups. Six cell subtypes were annotated, with prognostic genes predominantly expressed in myeloid cells. RT-qPCR revealed that PTAFR, FCGR2A, RETN and CAT were significantly downregulated, while TLR2 and S100A12 were upregulated in cALL. TLR2, PTAFR, FCGR2A, RETN, S100A12 and CAT may serve as potential therapeutic targets.
DOI: 10.6084/m9.figshare.29796120.v1
title: Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study

description: Objective: Current research links cytokines to cancer occurrence and development. This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. Methods: We analyzed 91 circulating cytokines as exposures and MDS genome-wide association study (GWAS) summary statistics as outcomes using a two-sample MR approach, with primary results derived from the IVW method. Robustness was assessed through heterogeneity, horizontal pleiotropy, and leave-one-out analyses. Results: In this study, T-cell surface glycoprotein CD6 isoform (OR = 1.247, 95% CI: 1.020-1.524, <i>p</i> = 0.031) and interleukin-24 (OR = 1.679, 95% CI: 1.056-2.669, <i>p</i> = 0.029) were positively associated with MDS risk, while cystatin D (OR = 0.778, 95% CI: 0.642-0.943, <i>p</i> = 0.010) and SIR2-like protein 2 (OR = 0.614, 95% CI: 0.385-0.979, <i>p</i> = 0.041) were negatively associated. These findings were stable in the sensitivity analysis. Conclusions: This MR study provides preliminary evidence that the genetically predicted levels of four circulating cytokines may influence the risk of developing MDS. The specific mechanisms require further exploration.
DOI: 10.6084/m9.figshare.29796120
title: Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study

description: Objective: Current research links cytokines to cancer occurrence and development. This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. Methods: We analyzed 91 circulating cytokines as exposures and MDS genome-wide association study (GWAS) summary statistics as outcomes using a two-sample MR approach, with primary results derived from the IVW method. Robustness was assessed through heterogeneity, horizontal pleiotropy, and leave-one-out analyses. Results: In this study, T-cell surface glycoprotein CD6 isoform (OR = 1.247, 95% CI: 1.020-1.524, <i>p</i> = 0.031) and interleukin-24 (OR = 1.679, 95% CI: 1.056-2.669, <i>p</i> = 0.029) were positively associated with MDS risk, while cystatin D (OR = 0.778, 95% CI: 0.642-0.943, <i>p</i> = 0.010) and SIR2-like protein 2 (OR = 0.614, 95% CI: 0.385-0.979, <i>p</i> = 0.041) were negatively associated. These findings were stable in the sensitivity analysis. Conclusions: This MR study provides preliminary evidence that the genetically predicted levels of four circulating cytokines may influence the risk of developing MDS. The specific mechanisms require further exploration.
DOI: 10.6084/m9.figshare.28059814
title: Identification of t(X;1)(q28;q21) generating a novel GATAD2B::MTCP1 gene fusion in CMML and its persistence during progression to AML

description: Hematological malignancies often involve chromosomal translocations and fusion genes that drive disease progression. While <i>MTCP1</i> is well-known in T-cell prolymphocytic leukemia (T-PLL), its role in myeloid neoplasms is less understood. This report presents the first identification of the t(X;1)(q28;q21) translocation leading to the <i>GATAD2B::MTCP1</i> fusion in acute myeloid leukemia (AML) transformed from chronic myelomonocytic leukemia (CMML). The karyotypes were described according to the International System for Human Cytogenetic Nomenclature 2009. We performed targeted next-generation sequencing (NGS) on a panel of 172 genes commonly mutated in hematological malignancies (Supplemental Table 1), using an Illumina platform. RNA sequencing was conducted on total RNA extracted from bone marrow, also using the Illumina platform. The <i>GATAD2B::MTCP1</i> fusion gene was confirmed by reverse transcription-polymerase chain reaction (RT–PCR) and Sanger sequencing, with specific primers for the fusion transcript (<i>GATAD2B</i>-F: CCTCTTTTTTTCGACGCC; <i>MTCP1</i>-R: ACTGAGCACAACACTTACGC). The <i>GATAD2B::MTCP1</i> fusion results from a breakpoint on 1q21 within <i>GATAD2B</i> exon 1 and Xq28 within <i>MTCP1</i> exon 2. The patient with the <i>GATAD2B::MTCP1</i> fusion exhibited disease progression from CMML to AML. Despite achieving initial remission with venetoclax-based therapy and allo-HSCT, the patient relapsed and died. We propose that the <i>GATAD2B::MTCP1</i> fusion upregulates <i>MTCP1</i> expression rather than generating a fusion protein, thereby contributing to transformation and relapse in AML. Further investigations are needed to elucidate the precise role of this fusion event in myeloid malignancies.
DOI: 10.6084/m9.figshare.28059814.v1
title: Identification of t(X;1)(q28;q21) generating a novel GATAD2B::MTCP1 gene fusion in CMML and its persistence during progression to AML

description: Hematological malignancies often involve chromosomal translocations and fusion genes that drive disease progression. While <i>MTCP1</i> is well-known in T-cell prolymphocytic leukemia (T-PLL), its role in myeloid neoplasms is less understood. This report presents the first identification of the t(X;1)(q28;q21) translocation leading to the <i>GATAD2B::MTCP1</i> fusion in acute myeloid leukemia (AML) transformed from chronic myelomonocytic leukemia (CMML). The karyotypes were described according to the International System for Human Cytogenetic Nomenclature 2009. We performed targeted next-generation sequencing (NGS) on a panel of 172 genes commonly mutated in hematological malignancies (Supplemental Table 1), using an Illumina platform. RNA sequencing was conducted on total RNA extracted from bone marrow, also using the Illumina platform. The <i>GATAD2B::MTCP1</i> fusion gene was confirmed by reverse transcription-polymerase chain reaction (RT–PCR) and Sanger sequencing, with specific primers for the fusion transcript (<i>GATAD2B</i>-F: CCTCTTTTTTTCGACGCC; <i>MTCP1</i>-R: ACTGAGCACAACACTTACGC). The <i>GATAD2B::MTCP1</i> fusion results from a breakpoint on 1q21 within <i>GATAD2B</i> exon 1 and Xq28 within <i>MTCP1</i> exon 2. The patient with the <i>GATAD2B::MTCP1</i> fusion exhibited disease progression from CMML to AML. Despite achieving initial remission with venetoclax-based therapy and allo-HSCT, the patient relapsed and died. We propose that the <i>GATAD2B::MTCP1</i> fusion upregulates <i>MTCP1</i> expression rather than generating a fusion protein, thereby contributing to transformation and relapse in AML. Further investigations are needed to elucidate the precise role of this fusion event in myeloid malignancies.
DOI: 10.6084/m9.figshare.28370250
title: Expression and clinical significance of histamine receptors in pediatric AML

description: This study investigates the expression and clinical significance of the histamine receptor family (HRs) in the bone marrow of children with newly diagnosed acute myeloid leukemia (AML). RNA sequencing was performed to assess the expression levels of HR family members (HRH1, HRH2, HRH3, and HRH4) in the bone marrow of 140 pediatric AML patients prior to chemotherapy. We compared the expression levels across various risk categories and assessed their relationship with prognosis using ROC curve analysis to evaluate predictive capabilities for outcomes. Among the 140 AML patients in our center, those with different FAB subtypes showed varying overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS). Specifically, the M2 and M4 subtypes showed better OS, EFS, and RFS, whereas the M5 subtype had poorer outcomes. Among patients with different fusion genes, those with AML1/ETO had superior OS, EFS, and RFS compared to other subtypes. Additionally, patients with CEBPA mutations demonstrated relatively favorable outcomes, whereas those with FLT3 mutations had poorer survival metrics. HRH1 expression was significantly higher in AML patients than in normal controls (<i>P</i> &lt; 0.05). Patients in the high HRH1 expression group had significantly better EFS and RFS than those in the low expression group (<i>P </i>&lt; 0.05). Furthermore, HRH1 expression was significantly higher in the low-risk (LR) group than in the intermediate and high-risk (IR & HR) groups (<i>P</i> &lt; 0.05). This finding suggests that HRH1 may serve as an early predictor of risk, EFS, and RFS. The clinical significance of HR family members varies in pediatric AML, with HRH1 identified as a valuable predictor of relapse in children with AML.
DOI: 10.6084/m9.figshare.28370250.v1
title: Expression and clinical significance of histamine receptors in pediatric AML

description: This study investigates the expression and clinical significance of the histamine receptor family (HRs) in the bone marrow of children with newly diagnosed acute myeloid leukemia (AML). RNA sequencing was performed to assess the expression levels of HR family members (HRH1, HRH2, HRH3, and HRH4) in the bone marrow of 140 pediatric AML patients prior to chemotherapy. We compared the expression levels across various risk categories and assessed their relationship with prognosis using ROC curve analysis to evaluate predictive capabilities for outcomes. Among the 140 AML patients in our center, those with different FAB subtypes showed varying overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS). Specifically, the M2 and M4 subtypes showed better OS, EFS, and RFS, whereas the M5 subtype had poorer outcomes. Among patients with different fusion genes, those with AML1/ETO had superior OS, EFS, and RFS compared to other subtypes. Additionally, patients with CEBPA mutations demonstrated relatively favorable outcomes, whereas those with FLT3 mutations had poorer survival metrics. HRH1 expression was significantly higher in AML patients than in normal controls (<i>P</i> &lt; 0.05). Patients in the high HRH1 expression group had significantly better EFS and RFS than those in the low expression group (<i>P </i>&lt; 0.05). Furthermore, HRH1 expression was significantly higher in the low-risk (LR) group than in the intermediate and high-risk (IR & HR) groups (<i>P</i> &lt; 0.05). This finding suggests that HRH1 may serve as an early predictor of risk, EFS, and RFS. The clinical significance of HR family members varies in pediatric AML, with HRH1 identified as a valuable predictor of relapse in children with AML.
DOI: 10.15468/dl.kqkgg3
title: Occurrence Download

description: A dataset containing 30743 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is Vespa velutina",
 "Year is one of (2024, 2025)",
 "HasCoordinate is true",
 "Geometry POLYGON((3.5 43.5, 12.5 43.5, 12.5 50.5, 3.5 50.5, 3.5 43.5))"
 ]
}

 The dataset includes 30743 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037177-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.7bez2s
title: Occurrence Download

description: A dataset containing 30743 species occurrences available in GBIF matching the query:
{
 "and" : [
 "SpeciesKey is Vespa velutina",
 "Year is one of (2024, 2025)",
 "HasCoordinate is true",
 "Geometry POLYGON((3.5 43.5, 12.5 43.5, 12.5 50.5, 3.5 50.5, 3.5 43.5))"
 ]
}

 The dataset includes 30743 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037176-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4uxax8
title: Occurrence Download

description: A dataset containing 436 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sapajus libidinosus",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 436 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037178-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.17840622
title: Digital Footprint and Its Impact on Improving Customer Experience: An Exploratory Study of a Sample of Internet Companies in Nineveh Governorate
DOI: 10.15468/dl.acru66
title: Occurrence Download

description: A dataset listing the 102 species recorded in GBIF matching the query:
{
 "DatasetKey" : [
 "is Pollinator diversity in traffic-related urban green spaces in Finland"
 ]
}

 The dataset's 102 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037160-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.eas9jh
title: Occurrence Download

description: A dataset containing 7029386 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Orthoptera"
 ]
}

 The dataset includes 7029386 records from 7045 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0037110-251120083545085/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8su1fs
title: Occurrence Download

description: A dataset containing 49546 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eudyptes Vieillot, 1816"
 ]
}

 The dataset includes 49546 records from 101 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030232-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.okll1n
title: Occurrence Download

description: A dataset containing 172098 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is G. S. Torrey Herbarium at the University of Connecticut (CONN)"
 ]
}

 The dataset includes 172098 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007141-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vw65y7
title: Occurrence Download

description: A dataset containing 73 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Lachesis acrochorda (Garcia, 1896)"
 ]
}

 The dataset includes 73 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010559-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ajn5nt
title: Occurrence Download

description: A dataset containing 368 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lonicera morrowii A.Gray",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 368 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030235-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3luaun
title: Occurrence Download

description: A dataset containing 17 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ctenomys dorsalis Thomas, 1900",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 17 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007141-180508205500799/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.deftc7
title: Occurrence Download

description: A dataset containing 19094 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Allium carinatum L."
 ]
}

 The dataset includes 19094 records from 271 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002425-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.otxdqc
title: Occurrence Download

description: A dataset containing 211 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Fallopia ×bohemica (Chrtek & Chrtková) J.P.Bailey",
 "Geometry POLYGON((-4.13 44.23,-4.13 55.47,23.42 55.47,23.42 44.23,-4.13 44.23))",
 "HasGeospatialIssue is false",
 "Year 1900-2020"
 ]
}

 The dataset includes 211 records from 15 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030236-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kjqrzw
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aloe adigratana Reynolds"
 ]
}

 The dataset includes 22 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002393-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ln1w6z
title: Occurrence Download

description: A dataset containing 1664 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pinus edulis Engelm."
 ]
}

 The dataset includes 1664 records from 69 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0007141-180730143533302/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3ndgkx
title: Occurrence Download

description: A dataset containing 2006 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Loxodonta africana (Blumenbach, 1797)"
 ]
}

 The dataset includes 2006 records from 72 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030237-160910150852091/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x1sjf8
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Vireo cassinii",
 "Country is Mexico",
 "HasCoordinate is true",
 "Geometry POLYGON((-99.184570 21.688057,-99.788818 21.616579,-100.909423 20.704738,-100.140380 19.870059,-98.865966 21.207458,-99.184570 21.688057))"
 ]
}

 The dataset includes 13 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0002270-150831095807960/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qqjmb2
title: Occurrence Download

description: A dataset containing 549697 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-31.565747 32.097476, 2.479608666666667 32.097476, 2.479608666666667 49.184106666666665, -31.565747 49.184106666666665, -31.565747 32.097476))",
 "EventDate is 2020-01-01,2020-01-31"
 ]
}

 The dataset includes 549697 records from 367 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020572-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.