cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6272885.v1
title: Immediate effects of temporary bite-raising with light-cured orthodontic band cement on the electromyographic response of masticatory muscles

description: Abstract Objective: To assess the immediate effects of temporary bite-raising using light-cured orthodontic band cement on the superficial masseter and anterior temporalis electromyography (EMG) activity in healthy adults. Materials and Methods: Surface EMG signals were recorded bilaterally from the superficial masseter and anterior temporalis muscles of 30 volunteers with a normal occlusion, before and after having temporary bite-raising. The bite-raising was done by adding light-cured orthodontic band cement (3x5x2 mm WxLxH) on the lingual cusps of both upper first molars. The measurements were recorded (i) at rest, (ii) while clenching in centric occluding position and (iii) while chewing on an artificial test food. The EMG activity at rest and during clenching, the maximum voltage, and the duration of the identified EMG signal burst while chewing the artificial test food before and after temporary bite-raising were statistically compared using the paired t-test or the Wilcoxon signed-rank test based on the normality of the variables. The significance level was set at 5%. Results: After temporary bite-raising, we found no significant change in integral EMG activity at rest position for the superficial masseter (mean difference (MD)=7.5 μVs) and for the anterior temporalis muscle (MD=36.8 μVs); however, the integral EMG activity during clenching was significantly reduced for the superficial masseter (MD=201.2 μVs) and for the anterior temporalis muscle (MD=151.8 μVs). During mastication, the maximum voltage of the identified burst was significantly reduced on the preferred chewing side of the superficial masseter and anterior temporalis muscles (MD=127.9 and 47.7 μV, respectively), while no significant change was found for the duration of the identified burst (MD=-34.1 and 3.4 ms, respectively) after temporary bite-raising. Conclusion: The results point to an altered neuromuscular behavior during clenching and chewing immediately after temporary bite-raising with light-cured orthodontic band cement. This information is relevant for orthodontists to inform their patients what will happen to their masticatory muscle activity when this bite-raising method is used.
DOI: 10.6084/m9.figshare.6272879
title: Analysis of multiple images for edge detection of Sobradinho Reservoir, in Bahia, Brazil

description: ABSTRACT Edge mapping tests of Sobradinho reservoir, Bahia, Brazil, were carried out on this work with TM Landsat-5 and MDE-SRTM images and SRTM-SWBD and ASTER-GDEM-VNIR edges. Mosaic of image segmentation band 4 TM sensor aided as comparative reference edge of the Sobradinho reservoir in relation to other images, and it was observed that the closest was the SRTM-SWBD edge of the NASA/NGA. Altimetry profiles were developed between MDE-SRTM edges, and also radiometric profiles, on the targeted band B4. It was found: low penetration of MDE-SRTM imaging in recessed edges of the reservoir, and discrepancies between the SRTM-SWBD edge (SWB) and the segmentation of the band 4.
DOI: 10.6084/m9.figshare.6272879.v1
title: Analysis of multiple images for edge detection of Sobradinho Reservoir, in Bahia, Brazil

description: ABSTRACT Edge mapping tests of Sobradinho reservoir, Bahia, Brazil, were carried out on this work with TM Landsat-5 and MDE-SRTM images and SRTM-SWBD and ASTER-GDEM-VNIR edges. Mosaic of image segmentation band 4 TM sensor aided as comparative reference edge of the Sobradinho reservoir in relation to other images, and it was observed that the closest was the SRTM-SWBD edge of the NASA/NGA. Altimetry profiles were developed between MDE-SRTM edges, and also radiometric profiles, on the targeted band B4. It was found: low penetration of MDE-SRTM imaging in recessed edges of the reservoir, and discrepancies between the SRTM-SWBD edge (SWB) and the segmentation of the band 4.
DOI: 10.6084/m9.figshare.6272876
title: Contradições na pesquisa e pós-graduação no Brasil

description: Abstract Scientific progress in Brazil has been subjected to a process of search and evaluation set by international targets and has achieved outstanding results. However, the same is not true for technological development or for school education. With notable exceptions, scientific progress has not translated into competence gains and improvements in the quality of life. The results achieved in science and technology and in the education of researchers are examined here to evaluate the hypothesis that severe contradictions exist between the education of researchers and scientific and technological results, which are in contrast with the needs of a society that strives to achieve tolerable standards, comparable to those of other nations. The discussion points to a strong trend to academicism, both in education and in research, that seeks to repeat results achieved by already developed societies. As a conclusion, greater effort from the scientific community is necessary in the new organizational environment to attain more effective and pragmatic results in research and in the development of researchers and teachers, as a means of making the society the largest beneficiary of knowledge.
DOI: 10.6084/m9.figshare.6272876.v1
title: Contradições na pesquisa e pós-graduação no Brasil

description: Abstract Scientific progress in Brazil has been subjected to a process of search and evaluation set by international targets and has achieved outstanding results. However, the same is not true for technological development or for school education. With notable exceptions, scientific progress has not translated into competence gains and improvements in the quality of life. The results achieved in science and technology and in the education of researchers are examined here to evaluate the hypothesis that severe contradictions exist between the education of researchers and scientific and technological results, which are in contrast with the needs of a society that strives to achieve tolerable standards, comparable to those of other nations. The discussion points to a strong trend to academicism, both in education and in research, that seeks to repeat results achieved by already developed societies. As a conclusion, greater effort from the scientific community is necessary in the new organizational environment to attain more effective and pragmatic results in research and in the development of researchers and teachers, as a means of making the society the largest beneficiary of knowledge.
DOI: 10.6084/m9.figshare.6272873
title: Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on treatment of gingival recession: a randomized, controlled clinical trial

description: Abstract Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG). Objective: The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure. Material and Methods: Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group. The plaque index (PI), gingival index (GI), probing depth (PD), keratinized tissue thickness (KTT), clinical attachment level (CAL), recession depth (RD), recession width (RW), and keratinized tissue height (KTH) measurements were performed at baseline and 1, 3, and 6 months after surgery. The post-operative discomfort of patients, assessed with the visual analog scale (VAS) and healing index (HI), was recorded after surgery. Results: PI, GI, and PD scores were similar for all patients at all times. RD and RW scores were similar for each patient at 1 month, but these values were significantly increased in the subsequent periods in test group-1. The increase in KTT was significantly higher in the control group compared with the test groups. Similar root coverage scores were obtained in the test group-2 and control groups, and these scores were significantly higher compared with test group-1. Conclusions: The PRF membrane+CAF technique may be an alternative to the CTG+CAF technique for postoperative patient comfort. However, PRF membranes should use as many layers as possible.
DOI: 10.6084/m9.figshare.6272873.v1
title: Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on treatment of gingival recession: a randomized, controlled clinical trial

description: Abstract Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG). Objective: The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure. Material and Methods: Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group. The plaque index (PI), gingival index (GI), probing depth (PD), keratinized tissue thickness (KTT), clinical attachment level (CAL), recession depth (RD), recession width (RW), and keratinized tissue height (KTH) measurements were performed at baseline and 1, 3, and 6 months after surgery. The post-operative discomfort of patients, assessed with the visual analog scale (VAS) and healing index (HI), was recorded after surgery. Results: PI, GI, and PD scores were similar for all patients at all times. RD and RW scores were similar for each patient at 1 month, but these values were significantly increased in the subsequent periods in test group-1. The increase in KTT was significantly higher in the control group compared with the test groups. Similar root coverage scores were obtained in the test group-2 and control groups, and these scores were significantly higher compared with test group-1. Conclusions: The PRF membrane+CAF technique may be an alternative to the CTG+CAF technique for postoperative patient comfort. However, PRF membranes should use as many layers as possible.
DOI: 10.6084/m9.figshare.6272870
title: Phospholipase immobilized in the hydrolysis of lipid fraction of the wastewater slaughterhouse swine: comparison with enzyme free

description: ABSTRACT This study intended to determine the best operating conditions for the hydrolysis of lipids present in wastewater of slaughterhouse swine comparing a free commercial phospholipase and an immobilized one, as well as the potential for reuse of the immobilized phospholipase in hydrolysis reactions and the maintenance of its lipolytic capacity in storage conditions. The influence of temperature, pH and concentration of phospholipase hydrolysis were analyzed, yielding optimal values such as 36ºC, 8.5 and 1.1% (w.v-1), respectively. The amounts of free fatty acids obtained for free and immobilized enzyme differed significantly (p&lt;0.05); the values were higher for the immobilized enzyme, with a maximum of 34 µmol.mL-1. There were performed 18 cycles of reuse in immobilized phospholipase hydrolysis reactions, and until the 17th reuse the relative activity was above 50%. The immobilized enzyme stored at refrigeration temperature remained the same fatty acids release until the 7th day of storage.
DOI: 10.6084/m9.figshare.6272870.v1
title: Phospholipase immobilized in the hydrolysis of lipid fraction of the wastewater slaughterhouse swine: comparison with enzyme free

description: ABSTRACT This study intended to determine the best operating conditions for the hydrolysis of lipids present in wastewater of slaughterhouse swine comparing a free commercial phospholipase and an immobilized one, as well as the potential for reuse of the immobilized phospholipase in hydrolysis reactions and the maintenance of its lipolytic capacity in storage conditions. The influence of temperature, pH and concentration of phospholipase hydrolysis were analyzed, yielding optimal values such as 36ºC, 8.5 and 1.1% (w.v-1), respectively. The amounts of free fatty acids obtained for free and immobilized enzyme differed significantly (p&lt;0.05); the values were higher for the immobilized enzyme, with a maximum of 34 µmol.mL-1. There were performed 18 cycles of reuse in immobilized phospholipase hydrolysis reactions, and until the 17th reuse the relative activity was above 50%. The immobilized enzyme stored at refrigeration temperature remained the same fatty acids release until the 7th day of storage.
DOI: 10.6084/m9.figshare.6272864
title: Pseudoaneurysms of the superficial temporal artery: three case reports

description: Abstract Pseudoaneurysms of the superficial temporal artery are rare events. They primarily occur in young men as a consequence of blunt head traumas. The majority of cases are asymptomatic, although there are sometimes vague symptoms. Ruptured pseudoaneurysms and development of neurological deficits are occasional complications. The authors describe three cases of pseudoaneurysm of the superficial temporal artery after blunt head trauma. Patients were successfully managed with ligature and resection of the pseudoaneurysms.
DOI: 10.6084/m9.figshare.6272864.v1
title: Pseudoaneurysms of the superficial temporal artery: three case reports

description: Abstract Pseudoaneurysms of the superficial temporal artery are rare events. They primarily occur in young men as a consequence of blunt head traumas. The majority of cases are asymptomatic, although there are sometimes vague symptoms. Ruptured pseudoaneurysms and development of neurological deficits are occasional complications. The authors describe three cases of pseudoaneurysm of the superficial temporal artery after blunt head trauma. Patients were successfully managed with ligature and resection of the pseudoaneurysms.
DOI: 10.6084/m9.figshare.6272858
title: Clinical and laboratory features of urinary tract infections in young infants

description: ABSTRACT Introduction: Urinary tract infection (UTI) is the most common serious bacterial infection in young infants. Signs and symptoms are often nonspecific. Objectives: To describe clinical, demographic and laboratory features of UTI in infants ≤ 3 months old. Methods: Cross-sectional study of infants ≤ 3 months old with UTI diagnosed in a pediatric emergency department, for the period 2010-2012. UTI was defined as ≥ 50,000 colony-forming units per milliliter of a single uropathogen isolated from bladder catheterization. Paired urinalysis and urine culture from group culture-positive and group culture-negative were used to determine the sensitivity and specificity of pyuria and nitrite tests in detecting UTI. Results: Of 519 urine cultures collected, UTI was diagnosed in 65 cases (prevalence: 12.5%); with male predominance (77%). The most common etiologies were Escherichia coli (56.9%), Klebsiella pneumoniae (18.5%) and Enterococcus faecalis (7.7%). Frequent clinical manifestations were fever (77.8%), irritability (41.4%) and vomiting (25.4%). The median temperature was 38.7°C. The sensitivity of the nitrite test was 30.8% (95%CI:19.9-43.4%), specificity of 100% (95%CI:99.2-100%). Pyuria ≥ 10,000/mL had a sensitivity of 87.7% (95%CI:77.2-94.5%), specificity of 74.9% (95%CI:70.6 -78.8%). The median peripheral white blood cell count was 13,150/mm3; C-reactive protein levels were normal in 30.5% of cases. Conclusions: The male: female ratio for urinary tract infection was 3.3:1. Non-Escherichia coli etiologies should be considered in empirical treatment. Fever was the main symptom. Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria ≥ 10,000/mL revealed good sensitivity, but low specificity. Peripheral white blood cell count and C-reactive protein concentration have limited usefulness to suggest UTI.
DOI: 10.6084/m9.figshare.6272858.v1
title: Clinical and laboratory features of urinary tract infections in young infants

description: ABSTRACT Introduction: Urinary tract infection (UTI) is the most common serious bacterial infection in young infants. Signs and symptoms are often nonspecific. Objectives: To describe clinical, demographic and laboratory features of UTI in infants ≤ 3 months old. Methods: Cross-sectional study of infants ≤ 3 months old with UTI diagnosed in a pediatric emergency department, for the period 2010-2012. UTI was defined as ≥ 50,000 colony-forming units per milliliter of a single uropathogen isolated from bladder catheterization. Paired urinalysis and urine culture from group culture-positive and group culture-negative were used to determine the sensitivity and specificity of pyuria and nitrite tests in detecting UTI. Results: Of 519 urine cultures collected, UTI was diagnosed in 65 cases (prevalence: 12.5%); with male predominance (77%). The most common etiologies were Escherichia coli (56.9%), Klebsiella pneumoniae (18.5%) and Enterococcus faecalis (7.7%). Frequent clinical manifestations were fever (77.8%), irritability (41.4%) and vomiting (25.4%). The median temperature was 38.7°C. The sensitivity of the nitrite test was 30.8% (95%CI:19.9-43.4%), specificity of 100% (95%CI:99.2-100%). Pyuria ≥ 10,000/mL had a sensitivity of 87.7% (95%CI:77.2-94.5%), specificity of 74.9% (95%CI:70.6 -78.8%). The median peripheral white blood cell count was 13,150/mm3; C-reactive protein levels were normal in 30.5% of cases. Conclusions: The male: female ratio for urinary tract infection was 3.3:1. Non-Escherichia coli etiologies should be considered in empirical treatment. Fever was the main symptom. Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria ≥ 10,000/mL revealed good sensitivity, but low specificity. Peripheral white blood cell count and C-reactive protein concentration have limited usefulness to suggest UTI.
DOI: 10.6084/m9.figshare.6272855
title: Preparation and Characterization of Nickel ferrite Nanoparticles via Co-precipitation Method

description: Nickel ferrite (NiFe2O4) nanoparticles were synthesized using co-precipitation method. The X-ray diffraction (XRD) pattern was used to determine the structure of NiFe2O4 nanoparticles. The presence of NiFe2O4 nanoparticles was confirmed by the FT-IR spectrum. The details of the surface morphology of NiFe2O4 nanoparticles were obtained by Scanning Electron Microscopic analysis. The particle size of the NiFe2O4 nanoparticles could be determined by means of Transmission Electron Microscopy. This work aimed at the investigation of the dielectric properties such as the dielectric loss and the dielectric constant of NiFe2O4 nanoparticles at varied frequencies and temperatures. In addition, the magnetic properties of the NiFe2O4 nanoparticles were studied.
DOI: 10.6084/m9.figshare.6272855.v1
title: Preparation and Characterization of Nickel ferrite Nanoparticles via Co-precipitation Method

description: Nickel ferrite (NiFe2O4) nanoparticles were synthesized using co-precipitation method. The X-ray diffraction (XRD) pattern was used to determine the structure of NiFe2O4 nanoparticles. The presence of NiFe2O4 nanoparticles was confirmed by the FT-IR spectrum. The details of the surface morphology of NiFe2O4 nanoparticles were obtained by Scanning Electron Microscopic analysis. The particle size of the NiFe2O4 nanoparticles could be determined by means of Transmission Electron Microscopy. This work aimed at the investigation of the dielectric properties such as the dielectric loss and the dielectric constant of NiFe2O4 nanoparticles at varied frequencies and temperatures. In addition, the magnetic properties of the NiFe2O4 nanoparticles were studied.
DOI: 10.6084/m9.figshare.6272846
title: Effect of vegetation on cutaneous leishmaniasis in Paraná, Brazil

description: BACKGROUND Cutaneous leishmaniasis (CL) is endemic in the state of Paraná, Brazil. OBJECTIVE This study aimed at analysing the influence of the remaining native vegetation on the prevalence of CL in Paraná. METHODS Global testing was used for spatial autocorrelation along with simultaneous autoregressive model (SAR). The regression was based on the CL coefficient (cases/100,000 inhabitants) as a function of the percentage of natural vegetation cover, altitude, total number of cases, and spatial density (SD) per km2; the location data of the Paraná state municipalities and the detection coefficient (DC) (cases/100,000 inhabitants) of autochthonous cases of CL were obtained from the SINAN in 2012 and 2016. Data on the remaining forests were collected from the Fundação SOS Mata Atlântica and Instituto Nacional de Pesquisas Espaciais. FINDINGS The spatial regression of DC revealed statistical significance for SD (Z = 24.1359, p &lt; 0.05, 2012-2013; Z = 24.0817, p &lt; 0.05, 2013-2014; Z = 33.4824, p &lt; 0.05, 2014-2015; and Z = 27.1515, p &lt; 0.05, 2015-2016. CONCLUSIONS CL cases are reported in areas with native vegetation, such as in riparian forests. However, vegetation is not the only variable that influences the incidence of CL.
DOI: 10.6084/m9.figshare.6272846.v1
title: Effect of vegetation on cutaneous leishmaniasis in Paraná, Brazil

description: BACKGROUND Cutaneous leishmaniasis (CL) is endemic in the state of Paraná, Brazil. OBJECTIVE This study aimed at analysing the influence of the remaining native vegetation on the prevalence of CL in Paraná. METHODS Global testing was used for spatial autocorrelation along with simultaneous autoregressive model (SAR). The regression was based on the CL coefficient (cases/100,000 inhabitants) as a function of the percentage of natural vegetation cover, altitude, total number of cases, and spatial density (SD) per km2; the location data of the Paraná state municipalities and the detection coefficient (DC) (cases/100,000 inhabitants) of autochthonous cases of CL were obtained from the SINAN in 2012 and 2016. Data on the remaining forests were collected from the Fundação SOS Mata Atlântica and Instituto Nacional de Pesquisas Espaciais. FINDINGS The spatial regression of DC revealed statistical significance for SD (Z = 24.1359, p &lt; 0.05, 2012-2013; Z = 24.0817, p &lt; 0.05, 2013-2014; Z = 33.4824, p &lt; 0.05, 2014-2015; and Z = 27.1515, p &lt; 0.05, 2015-2016. CONCLUSIONS CL cases are reported in areas with native vegetation, such as in riparian forests. However, vegetation is not the only variable that influences the incidence of CL.
DOI: 10.6084/m9.figshare.6272840
title: Recent Advances and Perspectives in Cancer Drug Design

description: ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and antibody-small molecule conjugates have emerged as a worthwhile approach to improve drug selectivity and reduce adverse effects, which are the main challenges in cancer drug discovery. This review will examine the current panorama of drug research and development (R&D) with emphasis on some of the major advances brought to clinical trials and to the market in the past five years. Breakthrough discoveries will be highlighted along with the medicinal chemistry strategies used throughout the discovery process. In addition, this review will provide perspectives and updates on the discovery of novel molecular targets as well as drugs with innovative mechanisms of action.