cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/nnm.22698853
title: Therapeutic outcome of quercetin nanoparticles on Cerastes cerastes venom-induced hepatorenal toxicity: a preclinical study - supplementary table

description: Aim: The objective of this study was to investigate the therapeutic potential of quercetin (QT) and
QT-loaded poly(lactic-co-glycolic acid) nanoparticles (QT-NPs) on Cerastes cerastes venom-mediated
inflammation, redox imbalance, hepatorenal tissue damage and local hemorrhage. Methods: The
developed QT-NPs were first submitted to physicochemical characterization and then evaluated in the
‘challenge then treat’ and ‘preincubation’ models of envenoming. Results: QT-NPs efficiently alleviated
hepatorenal toxicity, inflammation and redox imbalance and significantly attenuated venom-induced
local hemorrhage. Interestingly, QT-NPs were significantly more efficient than free QT at 24 h postenvenoming,
pointing to the efficacy of this drug-delivery system. Conclusion: These findings highlight
the therapeutic potential of QT-NPs on venom-induced toxicity and open up the avenue for their use in
the management of snakebite envenoming.
DOI: 10.25549/examiner-c44-18703
title: Crystal Lake fishing, 1950

description: 10 images. Crystal Lake fishing, 29 April 1950. Melissa Wessels; Kenneth Kirsop; Charles Rudolph; Clarence Neece.
DOI: 10.25402/nnm.22761587
title: Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS1000-functionalized nanoemulsion - supplementary data

description: Background: The present research was designed to develop a nanoemulsion (NE) of triphenylphosphine-
D-α-tocopheryl-polyethylene glycol succinate (TPP-TPGS1000) and paclitaxel (PTX) to effectively deliver
PTX to improve breast cancer therapy. Materials & methods: A quality-by-design approach was applied
for optimization and in vitro and in vivo characterization were performed. Results: The TPP-TPGS1000-
PTX-NE enhanced cellular uptake, mitochondrial membrane depolarization and G2M cell cycle arrest
compared with free-PTX treatment. In addition, pharmacokinetics, biodistribution and in vivo live
imaging studies in tumor-bearing mice showed that TPP-TPGS1000-PTX-NE had superior performance
compared with free-PTX treatment. Histological and survival investigations ascertained the nontoxicity
of the nanoformulation, suggesting new opportunities and potential to treat breast cancer. Conclusion:
TPP-TPGS1000-PTX-NE improved the efficacy of breast cancer treatment by enhancing its effectiveness and
decreasing drug toxicity.
DOI: 10.25549/examiner-c44-11290
title: Forger and blind victim, 1951

description: 4 images. Forger and blind victim, 25 July 1951. Miss Marjory Steward (victim); Karl Edwards.
DOI: 10.25402/nnm.22801202
title: Towards epigenetic regulation of triple-negative breast cancer via ligand-mediated nanoparticles - supplementary material

description: Aims: Develop and analyze triple-negative breast cancer targeted nanoparticles loaded with the
demethylating agent decitabine. Materials & methods: The polymers were synthesized by ring-opening
polymerization of D,l-lactide and formulated into nanoparticles via emulsion-evaporation method. The
nanoparticles were characterized by physicochemical analysis as well as in vitro using breast cancer
cell lineages. Results & conclusion: The targeted nanoparticles exhibited a hydrodynamic diameter of
75 ± 12 nm, zeta potential -6.3 ± 0.2 mV and spherical morphology, and displayed greater in vitro
accumulation into MDA-MB-231 (triple-negative breast cancer cell-line) compared with MCF7 and HB4A
cell lineages as verified by fluorescence confocal microscopy and significant demethylating effects via
ADAM33 screening by PCR.
DOI: 10.25402/nnm.22801400
title: The antidiabetic effect of superparamagnetic iron oxide nanoparticles highlights the role of WNT/AMPK/mTOR/FOXO1/mitochondrial DNA in muscle and kidney - supplementary materials

description: Aim: To explore the antidiabetic effect of superparamagnetic iron oxide nanoparticles (SPIONs)-PEG-550
and its related metabolic pathways in muscles and kidney. Materials & methods: Diabetes was induced in
5-day neonatal rats; after confirming diabetes, treatment with SPIONs-PEG-550 started at different doses
for 4 weeks. Routine analysis of glucose, insulin, adipocytokines, urea and creatinine was performed. The
expression of several genes involved in metabolic pathways and the corresponding protein levels were
examined. Results & conclusion: SPIONs-PEG-550 normalized the disturbed glucose homeostasis, reversed
insulin resistance, adjusted the serum level of adipocytokines, and improved several disturbed downstream
effectors of the insulin signaling and WNT pathway in both tissues. Histological examination of the muscle
and pancreas has shown almost normal functional characteristics without remarkable adverse effects on
the kidney.
DOI: 10.25402/nnm.22802498
title: The significance of quercetin-loaded advanced nanoformulations for the management of diabetic wounds - supplementary table

description: Quercetin is a well-known plant flavanol that exhibits multiple biological activities, including antioxidant,
anti-inflammatory and anticancer activities. The role of quercetin in wound healing has been widely
explored by a range of researchers in different models. However, the physicochemical properties, such
as solubility and permeability, of this compound are low, which ultimately limits its bioavailability on the
target site. To overcome these limitations for successful therapy, scientists have developed a range of
nanoformulations that provide effective therapeutic potential. In this review, the broad mechanism of
quercetin for acute and chronic wounds is covered. A compilation of recent advances on the horizon of
wound healing via quercetin is incorporated with several advanced nanoformulations.
DOI: 10.25549/examiner-c44-17551
title: Marines gypped, 1951

description: 2 images. Marines gypped, 2 September 1951. S.L. McClary; Vernon Kilpatrick; Corporal Gale Eyer; Corporal Robert Monaghan; Corporal Ralph Clark; Sergeant John McMillan; Sergeant Robert Rainey; Private First Class Robert Milloy.
DOI: 10.25402/nnm.22925051
title: Plasmonic nanoparticle-based surface-enhanced Raman spectroscopy-guided photothermal therapy: emerging cancer theranostics supplementary file

description: Optical imaging modalities have emerged as a keystone in oncological research, capable of providing
molecular and cellular information on cancer with the advantage of being minimally invasive toward
healthy tissues. Photothermal therapy (PTT) has shown great potential, with the exceptional advantages
of high specificity and noninvasiveness. Combining surface-enhanced Raman spectroscopy (SERS)-
based optical imaging with PTT has shown tremendous potential in cancer theranostics (therapeutics
+ diagnosis). This comprehensive review article provides up-to-date information by exploring recent
works focused mainly on the development of plasmonic nanoparticles formedical applications using SERSguided
PTT, including the fundamental principles behind SERS and the plasmon heating effect for PTT.
DOI: 10.25549/examiner-c44-109420
title: Navy pilot in China fight, 1954

description: 3 images. Navy pilot in China fight, 27 July 1954. Ensign Richard R. Crooks (at Corpus Christi) (copy). ; Caption slip reads: "Photographer: Mack. Date: 1954-07-27. Reporter: Dunn. Assignment: Navy pilot in China fight. 9/10: Copy of pix [sic] showing unnamed Admiral pinning wings on Ens. Richard R. Crooks at Corpus Christi. 19/20: Copy of pix [sic] showing full face of Ens. Richard R. Crooks of 171 North Fuller Avenue, Los Angeles."
DOI: 10.25402/nnm.23267066
title: Gold-, silver- and magnesium-doped zinc oxide nanoparticles prevents the formation of and eradicates bacterial biofilms - supplementary tables

description: Aim: This work aimed to synthesize magnesium-doped zinc oxide, silver and gold nanoparticles (Nps) and
to evaluate their potential to prevent and eradicate Escherichia coli, Proteus mirabilis, Staphylococcus
aureus, Acinetobacter baumannii and Pseudomonas aeruginosa biofilms. Materials & methods: The Nps
were synthesized by precipitation and metallic reduction techniques. Physicochemical and biological
characterization of Nps was performed. Results: All the Nps tested were able to inhibit the formation of E.
coli, P. mirabilis, S. aureus and A. baumannii biofilms. The effects on the eradication of preformed biofilms
were variable, although all the Nps tested were able to eradicate A. baumannii biofilms. Conclusion: The
observed effects make the Nps suitable for coating surfaces and/or antibiotic carriers with medical interest.
DOI: 10.25402/nnm.23267066.v1
title: Gold-, silver- and magnesium-doped zinc oxide nanoparticles prevents the formation of and eradicates bacterial biofilms - supplementary tables

description: Aim: This work aimed to synthesize magnesium-doped zinc oxide, silver and gold nanoparticles (Nps) and
to evaluate their potential to prevent and eradicate Escherichia coli, Proteus mirabilis, Staphylococcus
aureus, Acinetobacter baumannii and Pseudomonas aeruginosa biofilms. Materials & methods: The Nps
were synthesized by precipitation and metallic reduction techniques. Physicochemical and biological
characterization of Nps was performed. Results: All the Nps tested were able to inhibit the formation of E.
coli, P. mirabilis, S. aureus and A. baumannii biofilms. The effects on the eradication of preformed biofilms
were variable, although all the Nps tested were able to eradicate A. baumannii biofilms. Conclusion: The
observed effects make the Nps suitable for coating surfaces and/or antibiotic carriers with medical interest.
DOI: 10.25402/nnm.23283800
title: Nanoparticles for combined photo- and chemodynamic therapy of cancer cells involving endogenous glutathione depletion suppplementary data

description: Background: Reactive oxygen species (ROS) are powerful weapons for various anticancer therapies.
However, high glutathione (GSH) levels in cancer cells can significantly reduce the efficacy of such
therapies. Methods: In this study, pH-responsive fluorescein-encapsulated zeolitic imidazolate framework-
8 nanoparticles were synthesized for ROS-mediated combination therapy. Results: Upon blue light
activation, fluorescein displayed a high singlet oxygen photogeneration ability for photodynamic therapy.
Concurrently, accumulated Zn2+ from degraded zeolitic imidazolate framework-8 stimulated simultaneous
ROS generation and GSH depletion, thereby successfully inducing chemodynamic therapy. This triggered
a cascade of photo–physical and chemical processes culminating in the localized generation of ROS,
ultimately breaking the intracellular redox equilibrium. Conclusion: This nanoformulation can potentially
be used for light-activated ROS-mediated therapy for the management of superficial tumors.
DOI: 10.25402/nnm.23283800.v1
title: Nanoparticles for combined photo- and chemodynamic therapy of cancer cells involving endogenous glutathione depletion suppplementary data

description: Background: Reactive oxygen species (ROS) are powerful weapons for various anticancer therapies.
However, high glutathione (GSH) levels in cancer cells can significantly reduce the efficacy of such
therapies. Methods: In this study, pH-responsive fluorescein-encapsulated zeolitic imidazolate framework-
8 nanoparticles were synthesized for ROS-mediated combination therapy. Results: Upon blue light
activation, fluorescein displayed a high singlet oxygen photogeneration ability for photodynamic therapy.
Concurrently, accumulated Zn2+ from degraded zeolitic imidazolate framework-8 stimulated simultaneous
ROS generation and GSH depletion, thereby successfully inducing chemodynamic therapy. This triggered
a cascade of photo–physical and chemical processes culminating in the localized generation of ROS,
ultimately breaking the intracellular redox equilibrium. Conclusion: This nanoformulation can potentially
be used for light-activated ROS-mediated therapy for the management of superficial tumors.
DOI: 10.25549/examiner-c44-16871
title: Olympic fights, 1951

description: 6 images. Olympic fights, 17 July 1951. Jackie Graves versus Manuel Ortiz.
DOI: 10.25402/nnm.23501103
title: Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy - supporting information

description: Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates
tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl
alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs
were synthesized and intravenously injected into tumor-bearingmice for BNCT. Results: The in vitro boron
uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful
BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically
used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective
therapeutic results for oral cancer treatments in BNCT.
DOI: 10.25402/nnm.23501103.v1
title: Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy - supporting information

description: Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates
tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl
alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs
were synthesized and intravenously injected into tumor-bearingmice for BNCT. Results: The in vitro boron
uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful
BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically
used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective
therapeutic results for oral cancer treatments in BNCT.
DOI: 10.25549/examiner-c44-17719
title: Ensenada Yacht Race, [n.d.]

description: 6 images. Ensenada Yacht Race, [n.d.].
DOI: 10.25549/examiner-c44-54621
title: City Council, 1953

description: 5 images. City Council, 30 June 1953. Arthur Morris (Minutes clerk); Harold Harby; John C. Holland; Gordon Hahn; Ray Chesbro (City Attorney); George Cronk.; Caption slip reads: "Photographer: Brunk. Date: 06-30. Assignment: Council. B50: City Attorney Ray Chesbro explains to George Cronk that nothing legally apply to the present situation".
DOI: 10.15468/dl.zqhp8p
title: Occurrence Download

description: A dataset containing 26047 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Echinocystis lobata (Michx.) Torr. & A.Gray)"
 ]
}

 The dataset includes 26047 records from 307 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017271-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/examiner-c44-73280
title: Lake Hughes fire, 1953

description: 17 images. Lake Hughes fire, 24 August 1953. General views of brush fire at Lake Hughes.; Caption slip reads: "Photographer: Olmo. Date: 1953-08-24. Reporter: Adler. Assignment: Lake Hughes fire. Brush fire near Lake Hughes. Firemen & boys trying to keep flames from jumping firebreak; County Fire Chief Keith Klinger".
DOI: 10.25549/examiner-c44-102149
title: Hearst Regatta, 1952

description: 26 images. Hearst Regatta, 27 July 1952.; Supplementary material reads: "Trophy pix. Eddie Maroney, winner. Little Valentine".
DOI: 10.15131/shef.data.25800409
title: Code and data for 'Individual bacterial cells can use spatial sensing of chemical gradients to direct chemotaxis on surfaces'

description: This repository contains code and data for our manuscript 'Wheeler JHR, Foster KR, Durham WM: <i>Individual bacterial cells can use spatial sensing of chemical gradients to direct chemotaxis on surfaces</i>. Nat. Micro 2024'. There is a 'Readme' document within the parent folder that details the entire contents of the repository and explains how our code and data were used to generate each of the figures in our manuscript. Please direct any queries to the corresponding authors.
DOI: 10.15131/shef.data.25800409.v1
title: Code and data for 'Individual bacterial cells can use spatial sensing of chemical gradients to direct chemotaxis on surfaces'

description: This repository contains code and data for our manuscript 'Wheeler JHR, Foster KR, Durham WM: <i>Individual bacterial cells can use spatial sensing of chemical gradients to direct chemotaxis on surfaces</i>. Nat. Micro 2024'. There is a 'Readme' document within the parent folder that details the entire contents of the repository and explains how our code and data were used to generate each of the figures in our manuscript. Please direct any queries to the corresponding authors.
DOI: 10.25402/nnm.23798865
title: Curcumin-reduced gold nanoparticles facilitate IL-12 delivery to a cervical cancer <i>in </i><i>vitro</i> cell model - supplementary data

description: Aim: To synthesize curcumin-reduced gold nanoparticles (AuNPs) for the efficient delivery to and expression of the IL-12 gene in cervical cancer (HeLa) cells in vitro. Methods: Curcumin-reduced AuNPs were synthesized, stabilized with poly-L-lysine and PEG, conjugated to IL-12 DNA and physicochemically characterized. Cytotoxicity and IL-12 expression were accessed in vitro. Results & discussion: Stable, spherical AuNPs effectively compacted and protected the IL-12 DNA and tolerated well in vitro. Realtime quantitative PCR and ELISA confirmed the successful delivery and expression of the IL-12 gene in HeLa cells. Conclusion: The favorable attributes of this AuNP-delivery system and the significant IL-12 expression obtained augur well for cytokine-based therapy or immunotherapy in cervical cancer.
DOI: 10.25402/nnm.23798865.v1
title: Curcumin-reduced gold nanoparticles facilitate IL-12 delivery to a cervical cancer <i>in </i><i>vitro</i> cell model - supplementary data

description: Aim: To synthesize curcumin-reduced gold nanoparticles (AuNPs) for the efficient delivery to and expression of the IL-12 gene in cervical cancer (HeLa) cells in vitro. Methods: Curcumin-reduced AuNPs were synthesized, stabilized with poly-L-lysine and PEG, conjugated to IL-12 DNA and physicochemically characterized. Cytotoxicity and IL-12 expression were accessed in vitro. Results & discussion: Stable, spherical AuNPs effectively compacted and protected the IL-12 DNA and tolerated well in vitro. Realtime quantitative PCR and ELISA confirmed the successful delivery and expression of the IL-12 gene in HeLa cells. Conclusion: The favorable attributes of this AuNP-delivery system and the significant IL-12 expression obtained augur well for cytokine-based therapy or immunotherapy in cervical cancer.
DOI: 10.25549/examiner-c44-73264
title: Rim-of-the-World fire (Lake Arrowhead), 1953

description: 12 images. Rim-of-the-World fire (Lake Arrowhead), 27 August 1953. Vernet Poupitch (moves furniture from his house); Deputy Sheriff Duane Mellinger; Dave Leamon (Lake Arrowhead Forest Service).; Caption slip reads: "Photographer: Paegel. Date: 1953-08-27. Reporter: Harmon. Assignment: Arrowhead Fire. 15-16-17-18: Views looking East of Arrowhead Highlands -- Crest Forest Fire Equipment in foreground standing by".; Additional caption slip reads: "Photographer: Forbes. Date: 1953-08-27. Assignment: Fire. 1: Flames jump Rim of World Road. 146: Indians from Arizona rest & eat. 145-138: Cutting tree with power saw. 27: Vernet Poupitch moves furniture from his place at Rim Forest. 137: Dep Sher Duane Mellinger tells people to move. 135-136-304: Dave Leamon, Lake Arrowhead Forestry Service off Blue Jay Daily Canyon. 137: Dep Sher Duane Mellinger telling people to move".
DOI: 10.25402/nnm.23798868
title: Quality-by-design-based development of ultradeformable nanovesiculartransgelosome of standardized <i>Piper longum</i> extract for melanoma - supplementary data

description: Background: Melanoma is the most aggressive and deadly form of skin cancer. The stratum corneum of the skin is a major obstacle to dermal and transdermal drug delivery. Ultradeformable nanovesicular transferosome has the capacity for deeper skin penetration and its incorporation into hydrogel forms a transgelosome that has better skin permeability and patient compliance. Method: Here, the quality-by-design-based development and optimization of nanovesicular transgelosome of standardized <i>Piper </i><i>longum</i> fruit ethanolic extract (PLFEE) for melanoma therapy are reported. Results: Compared with standardized PLFEE-loaded plain gel, the transgelosome displayed optimal pharmaceutical properties and improved ex vivo skin permeability and in vivo tumor regression in B16F10 melanoma-bearing C57BL/6 mice. Conclusion: The results reflect the potential of transgelosome for melanoma therapy.
DOI: 10.25402/nnm.23798868.v1
title: Quality-by-design-based development of ultradeformable nanovesiculartransgelosome of standardized <i>Piper longum</i> extract for melanoma - supplementary data

description: Background: Melanoma is the most aggressive and deadly form of skin cancer. The stratum corneum of the skin is a major obstacle to dermal and transdermal drug delivery. Ultradeformable nanovesicular transferosome has the capacity for deeper skin penetration and its incorporation into hydrogel forms a transgelosome that has better skin permeability and patient compliance. Method: Here, the quality-by-design-based development and optimization of nanovesicular transgelosome of standardized <i>Piper </i><i>longum</i> fruit ethanolic extract (PLFEE) for melanoma therapy are reported. Results: Compared with standardized PLFEE-loaded plain gel, the transgelosome displayed optimal pharmaceutical properties and improved ex vivo skin permeability and in vivo tumor regression in B16F10 melanoma-bearing C57BL/6 mice. Conclusion: The results reflect the potential of transgelosome for melanoma therapy.