cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28089167
title: Poloxamer 188 stabilized poly (ε-caprolactone) microspheres of voriconazole for targeting pulmonary aspergillosis

description: Voriconazole (VRZ) is highly effective in treating invasive pulmonary aspergillosis (IPA), in addition to hepatotoxicity. Therefore, the current study focuses on the development and characterization of voriconazole-loaded microspheres (VRZ@PCL MSPs) to augment pulmonary localization and antifungal efficacy. VRZ@PCL MSPs were fabricated by using the o/w emulsion method. The optimized F3VRZ@PCL MSPs were subjected to physicochemical characterization, in vitro release, hemocompatibility, antifungal efficacy as well as pharmacokinetic and biodistribution evaluation. The optimized F3VRZ@MSPs exhibited a particle size (10.90 ± 2.61 µm), entrapment efficiency (19.35 ± 2.47%), drug loading (3.22 ± 0.41%) with sustained release behavior up to 24 h and hemocompatibility upto 50 µg/mL. Results of antifungal testing indicated the superior antifungal potential of F3VRZ@PCL MSPs as compared to free VRZ and nystatin. In vivo pharmacokinetic evaluation in Sprague-Dawley rats displayed 12.5-fold and 4.5-fold increments, respectively, in t<sub>1/2</sub> and AUC<sub>0-t</sub> of F3VRZ@PCL MSPs as compared to free VRZ. Moreover, F3VRZ@PCL MSPs displayed relatively higher lung targeting with a drug targeting index (DTI) of 0.213 as compared to DTI of 0.037 of free VRZ. In conclusion, F3VRZ@PCL MSPs offer a promising approach for sustained and targeted delivery of VRZ and hold the potential to offer high therapeutic efficacy in the treatment of IPA.
DOI: 10.6084/m9.figshare.28089167.v1
title: Poloxamer 188 stabilized poly (ε-caprolactone) microspheres of voriconazole for targeting pulmonary aspergillosis

description: Voriconazole (VRZ) is highly effective in treating invasive pulmonary aspergillosis (IPA), in addition to hepatotoxicity. Therefore, the current study focuses on the development and characterization of voriconazole-loaded microspheres (VRZ@PCL MSPs) to augment pulmonary localization and antifungal efficacy. VRZ@PCL MSPs were fabricated by using the o/w emulsion method. The optimized F3VRZ@PCL MSPs were subjected to physicochemical characterization, in vitro release, hemocompatibility, antifungal efficacy as well as pharmacokinetic and biodistribution evaluation. The optimized F3VRZ@MSPs exhibited a particle size (10.90 ± 2.61 µm), entrapment efficiency (19.35 ± 2.47%), drug loading (3.22 ± 0.41%) with sustained release behavior up to 24 h and hemocompatibility upto 50 µg/mL. Results of antifungal testing indicated the superior antifungal potential of F3VRZ@PCL MSPs as compared to free VRZ and nystatin. In vivo pharmacokinetic evaluation in Sprague-Dawley rats displayed 12.5-fold and 4.5-fold increments, respectively, in t<sub>1/2</sub> and AUC<sub>0-t</sub> of F3VRZ@PCL MSPs as compared to free VRZ. Moreover, F3VRZ@PCL MSPs displayed relatively higher lung targeting with a drug targeting index (DTI) of 0.213 as compared to DTI of 0.037 of free VRZ. In conclusion, F3VRZ@PCL MSPs offer a promising approach for sustained and targeted delivery of VRZ and hold the potential to offer high therapeutic efficacy in the treatment of IPA.
DOI: 10.6084/m9.figshare.28302698
title: Development and optimization of raloxifene hydrochloride loaded lipid nanocapsule based hydrogel for transdermal delivery

description: Development and optimization of raloxifene hydrochloride loaded lipid nanocapsule hydrogel for transdermal delivery. A 3<sup>3</sup> Box-Behnken Design and numerical optimization was performed to obtain the optimized formulation. Subsequently, the optimized raloxifene hydrochloride loaded lipid nanocapsule was developed using phase inversion temperature and characterized for physicochemical properties. Furthermore, the optimized lipid nanocapsule was loaded into a hydrogel and evaluated for rheology, spreadability, ex-vivo skin permeation, deposition and irritation. The numerical optimization suggested an optimal formula with desirability value of 0.852 and low prediction errors. The optimized formulation showed good % drug entrapment efficiency (79.56 ± 2.34%), nanometer size (56.68 ± 1.2 nm), monodisperse nature (PDI = 0.176 ± 0.2), spherical morphology and good drug-excipient compatibility. The raloxifene hydrochloride loaded lipid nanocapsule hydrogel showed shear thinning properties, sustained drug delivery, dermal compatibility and significantly higher permeability (2-fold), retention (3.37) for raloxifene hydrochloride compared to the control. The present study showed a successful development of raloxifene hydrochloride loaded lipid nanocapsule hydrogel with improved skin permeation, retention, and good topical compatibility. This formulation may overcome the challenges associated with raloxifene hydrochloride oral delivery including low bioavailability. Raloxifene hydrochloride is used for the treatment of osteoporosis in women who have undergone menopause. It is available in market as a tablet. However, currently available tablets are only able to deliver a small quantity of the drug into the parts of the body where it is needed, reducing the effects of the medication. This occurs due to the low solubility of Raloxifene hydrochloride in the water and extensive metabolism by the liver before reaching to the systemic circulation. The authors in this study prepared a new gel for skin application. They anticipated that the drug from this gel would slowly and efficiently reach to the site of action from the skin. This will reduce the incidences of unwanted effects and improve the condition of osteoporosis in postmenopausal women. The authors evaluated the drug release behavior, skin absorption, deposition, and safety of the developed gel in rats. They found that the prepared gel slowly and efficiently releases the drug across the skin with no signs of irritation.
DOI: 10.6084/m9.figshare.28302698.v1
title: Development and optimization of raloxifene hydrochloride loaded lipid nanocapsule based hydrogel for transdermal delivery

description: Development and optimization of raloxifene hydrochloride loaded lipid nanocapsule hydrogel for transdermal delivery. A 3<sup>3</sup> Box-Behnken Design and numerical optimization was performed to obtain the optimized formulation. Subsequently, the optimized raloxifene hydrochloride loaded lipid nanocapsule was developed using phase inversion temperature and characterized for physicochemical properties. Furthermore, the optimized lipid nanocapsule was loaded into a hydrogel and evaluated for rheology, spreadability, ex-vivo skin permeation, deposition and irritation. The numerical optimization suggested an optimal formula with desirability value of 0.852 and low prediction errors. The optimized formulation showed good % drug entrapment efficiency (79.56 ± 2.34%), nanometer size (56.68 ± 1.2 nm), monodisperse nature (PDI = 0.176 ± 0.2), spherical morphology and good drug-excipient compatibility. The raloxifene hydrochloride loaded lipid nanocapsule hydrogel showed shear thinning properties, sustained drug delivery, dermal compatibility and significantly higher permeability (2-fold), retention (3.37) for raloxifene hydrochloride compared to the control. The present study showed a successful development of raloxifene hydrochloride loaded lipid nanocapsule hydrogel with improved skin permeation, retention, and good topical compatibility. This formulation may overcome the challenges associated with raloxifene hydrochloride oral delivery including low bioavailability. Raloxifene hydrochloride is used for the treatment of osteoporosis in women who have undergone menopause. It is available in market as a tablet. However, currently available tablets are only able to deliver a small quantity of the drug into the parts of the body where it is needed, reducing the effects of the medication. This occurs due to the low solubility of Raloxifene hydrochloride in the water and extensive metabolism by the liver before reaching to the systemic circulation. The authors in this study prepared a new gel for skin application. They anticipated that the drug from this gel would slowly and efficiently reach to the site of action from the skin. This will reduce the incidences of unwanted effects and improve the condition of osteoporosis in postmenopausal women. The authors evaluated the drug release behavior, skin absorption, deposition, and safety of the developed gel in rats. They found that the prepared gel slowly and efficiently releases the drug across the skin with no signs of irritation.
DOI: 10.18150/awos5q
title: Replication data for: Monolayers of amino acid-synthesized gold nanoparticles as SERS substrates for trace chemical sensing

description: These data refer to studies on developing, characterizing, and testing SERS substrates in the form of monolayers of amino acid-synthesized gold nanoparticles on glass and silicon platforms. The provided are input data for SERS spectra and XPS spectra presented in the article and supporting information.
DOI: 10.6084/m9.figshare.28457405
title: PEMFC_HELP_MARTIN.rar

description: problem with PEMFC Ansys Fluent - fluid or solid membrane
DOI: 10.6084/m9.figshare.28457405.v1
title: PEMFC_HELP_MARTIN.rar

description: problem with PEMFC Ansys Fluent - fluid or solid membrane
DOI: 10.15128/r1nz805z75v
title: Processed Construction Task Data for Multi-Objective Optimization of Construction Scheduling Based on Grey Wolf Optimization Algorithm [dataset]

description: This dataset is structured to support research in construction scheduling, task optimization, and resource allocation. It includes task dependencies, material requirements, and productivity rates.
description: This study proposes a data-supported multi-objective optimization model for construction scheduling, integrating structured task-resource datasets to improve decision-making. Using Grey Wolf Optimization (GWO), the model aims to minimize project duration while maximizing resource utilization, addressing challenges in scheduling feasibility. Comparative experiments with Particle Swarm Optimization (PSO) and Sparrow Search Algorithm (SSA) demonstrate that GWO achieves better optimization stability and constraint handling, reducing premature convergence and improving solution feasibility. Although the current model relies on static datasets, future research could enhance adaptability by incorporating real-time project data and machine learning-driven scheduling predictions.
description: This dataset was compiled from multiple academic sources on construction scheduling. The raw data was manually extracted, cleaned, and structured into an Excel format. The processing steps included standardizing time units, defining task dependencies, and structuring productivity data. The dataset is suitable for use in construction scheduling optimization and multi-objective decision analysis.
DOI: 10.15468/dl.jbq2g7
title: Occurrence Download

description: A dataset containing 141194 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (Bugbase, Lepidopterological Society, Artportalen, Suffolk Biodiversity Information Service (SBIS) Dataset, Observatoire de la Biodiversité des Jardins (OBJ)-Données Observatoire des Papillons des Jardins, NABU|naturgucker, UK Butterfly Monitoring Scheme (UKBMS), Natural History Museum Rotterdam - Observations, Macro-moth distribution records for the UK from Butterfly Conservation, up to 2019)",
 "TaxonKey is Tyria jacobaeae Linnaeus, 1758"
 ]
}

 The dataset includes 141194 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000052-250221090833381/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nn86sc
title: Occurrence Download

description: A dataset listing the 1 species recorded in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Pemphis acidula J.R.Forst. & G.Forst."
 ]
}

 The dataset's 1 records were derived from 90 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000053-250221090833381/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tvjcpk
title: Occurrence Download

description: A dataset containing 462931 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Asio flammeus (Pontoppidan, 1763)"
 ]
}

 The dataset includes 462931 records from 944 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000044-250221090833381/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3wfjth
title: Occurrence Download

description: A dataset listing the 56247 species recorded in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aves"
 ]
}

 The dataset's 56247 records were derived from 15587 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017798-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.z8cwgm
title: Occurrence Download

description: A dataset containing 90 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pollia subumbellata C.B.Clarke"
 ]
}

 The dataset includes 90 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0089818-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u6r9qh
title: Occurrence Download

description: A dataset containing 32149 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is EOD – eBird Observation Dataset",
 "Geometry POLYGON((-74.98739 10.90609,-74.74297 10.90609,-74.74297 11.12407,-74.98739 11.12407,-74.98739 10.90609))"
 ]
}

 The dataset includes 32149 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0099369-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u2zvyw
title: Occurrence Download

description: A dataset containing 297 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Schinia lucens Morrison, 1875"
 ]
}

 The dataset includes 297 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0074547-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.yjj2s9
title: Occurrence Download

description: A dataset containing 245 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Limopsis multistriata (Forsskål, 1775)"
 ]
}

 The dataset includes 245 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0106941-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4ssn22
title: Occurrence Download

description: A dataset containing 2243 species occurrences available in GBIF matching the query:
{
 "and" : [
 "VerbatimScientificName is Alipiopsitta xanthops",
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Year 2011-2021",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Specimen, Material citation, Material sample)"
 ]
 }
 }
 ]
}

 The dataset includes 2243 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0089817-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gebgvq
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Pakistan, Afghanistan, Uzbekistan, Tajikistan, Turkmenistan, Kazakhstan, Kyrgyzstan)",
 "TaxonKey is Meles meles (Linnaeus, 1758)"
 ]
}

 The dataset includes 2 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0106940-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.kqtv8f
title: Occurrence Download

description: A dataset containing 331 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ilex cassine L.",
 {
 "not" : {
 "Country" : [
 "is United States of America"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is unknown or invalid"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is United States"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is United States of America"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is Canada"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is Canada"
 ]
 }
 },
 {
 "not" : {
 "Continent" : [
 "is North America"
 ]
 }
 }
 ]
}

 The dataset includes 331 records from 48 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045885-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pcskt4
title: Occurrence Download

description: A dataset containing 63 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Moschus berezovskii Flerov, 1929"
 ]
}

 The dataset includes 63 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0106946-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.u4cuzn
title: Occurrence Download

description: A dataset containing 281 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Itea virginica L.",
 {
 "not" : {
 "Country" : [
 "is United States of America"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is unknown or invalid"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is United States"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is United States of America"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is Canada"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is Canada"
 ]
 }
 },
 {
 "not" : {
 "Continent" : [
 "is North America"
 ]
 }
 }
 ]
}

 The dataset includes 281 records from 46 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045896-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.tn42px
title: Occurrence Download

description: A dataset containing 455 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-118.0459386999999936 34.1141602000000006, -118.0459386999999936 34.1165092600000008, -118.0459386999999936 34.1188583200000011, -118.0459386999999936 34.1204733000000004, -118.0459386999999936 34.1242905300000032, -118.0459386999999936 34.1273736699999972, -118.0459386999999936 34.1294291000000030, -118.0440222499999976 34.1294291000000030, -118.0413687100000004 34.1294291000000030, -118.0378306500000036 34.1294291000000030, -118.0351771100000065 34.1294291000000030, -118.0311968000000036 34.1294291000000030, -118.0311968000000036 34.1254650600000033, -118.0311968000000036 34.1234096299999976, -118.0311968000000036 34.1203264899999965, -118.0311968000000036 34.1178306099999986, -118.0311968000000036 34.1141602000000006, -118.0347348600000004 34.1141602000000006, -118.0376832400000069 34.1141602000000006, -118.0410738700000053 34.1141602000000006, -118.0429903200000012 34.1141602000000006, -118.0459386999999936 34.1141602000000006))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 455 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075334-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4r6ecm
title: Occurrence Download

description: A dataset containing 708 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Ilex verticillata (L.) A.Gray",
 {
 "not" : {
 "Country" : [
 "is United States of America"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is unknown or invalid"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is United States"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is United States of America"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is Canada"
 ]
 }
 },
 {
 "not" : {
 "Country" : [
 "is Canada"
 ]
 }
 },
 {
 "not" : {
 "Continent" : [
 "is North America"
 ]
 }
 }
 ]
}

 The dataset includes 708 records from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0045892-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9wrgvx
title: Occurrence Download

description: A dataset containing 3313 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-117.7254956999999962 34.0981671999999989, -117.7254956999999962 34.0990725099999992, -117.7254956999999962 34.1010641900000024, -117.7254956999999962 34.1023316300000019, -117.7254956999999962 34.1037801200000033, -117.7254956999999962 34.1060433999999972, -117.7254956999999962 34.1072203000000016, -117.7224137900000045 34.1072203000000016, -117.7205101899999988 34.1072203000000016, -117.7189691800000020 34.1072203000000016, -117.7173375200000009 34.1072203000000016, -117.7149808000000064 34.1072203000000016, -117.7149808000000064 34.1056812699999981, -117.7149808000000064 34.1038706499999975, -117.7149808000000064 34.1026032199999989, -117.7149808000000064 34.1008831299999997, -117.7149808000000064 34.0993441000000033, -117.7149808000000064 34.0981671999999989, -117.7178814100000039 34.0981671999999989, -117.7206008400000030 34.0981671999999989, -117.7219605599999994 34.0981671999999989, -117.7241360999999955 34.0981671999999989, -117.7254956999999962 34.0981671999999989))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 3313 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0075347-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vc8b9g
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Splendrillia basilirata Sysoev, 1990"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0099380-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.