cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5281/zenodo.5500215
title: HELIX: Data-driven characterization of Brazilian land snails

description: The Subulinidae family of Brazilian land snails includes similar species with particular morphometrical characteristics. We surveyed the metro area of the Juiz de Fora/MG city and collected snails from a representative private property with centered at 21º42'31''S, 43º21'26'', alt. 795m, with red-yellow oxisol, 8.5 pH, and Cwa climate. We performed monthly collections in a ecosystem with <em>Pennisetum purpureum</em>, <em>Brachiaria mutica</em>, <em>Paspalum notatum</em>, <em>Bidens pilosa</em>, <em>Leucena leucocephala</em>, and <em>Ricinus communis</em> plants near a river flow in the 2008/Sep - 2009/Aug timespan. There, we defined an equally spaced transect of 200m with ten collection points and gathered 50 x 50 cm, 500 g litter-falls. Samples were sieved by 2.0 mm meshs, and living specimens were cleaned and fixed in a Railliet-Henry liquid, their shells removed, dried, and separated. Finally, we label the species and create the Helix dataset. We measured each shell <em>Height</em>, <em>Diameter</em>, <em>Spire height</em>, and <em>Aperture width</em> and <em>height</em> with a pachymeter. The dataset includes 518 instances labeled as <em><strong>Beckianum beckianum</strong></em> (28.8%), <em><strong>Dysopeas muibum</strong></em> (21.2%), <em><strong>Allopeas gracilis</strong></em> (9.7%), <em><strong>Leptinaria unilamellata </strong></em>(12%), and <em><strong>Subulina octona</strong></em> (28.3%).
description: http://arxiv.org/abs/2109.04903
DOI: 10.5281/zenodo.5500214
title: HELIX: Data-driven characterization of Brazilian land snails

description: The Subulinidae family of Brazilian land snails includes similar species with particular morphometrical characteristics. We surveyed the metro area of the Juiz de Fora/MG city and collected snails from a representative private property with centered at 21º42'31''S, 43º21'26'', alt. 795m, with red-yellow oxisol, 8.5 pH, and Cwa climate. We performed monthly collections in a ecosystem with <em>Pennisetum purpureum</em>, <em>Brachiaria mutica</em>, <em>Paspalum notatum</em>, <em>Bidens pilosa</em>, <em>Leucena leucocephala</em>, and <em>Ricinus communis</em> plants near a river flow in the 2008/Sep - 2009/Aug timespan. There, we defined an equally spaced transect of 200m with ten collection points and gathered 50 x 50 cm, 500 g litter-falls. Samples were sieved by 2.0 mm meshs, and living specimens were cleaned and fixed in a Railliet-Henry liquid, their shells removed, dried, and separated. Finally, we label the species and create the Helix dataset. We measured each shell <em>Height</em>, <em>Diameter</em>, <em>Spire height</em>, and <em>Aperture width</em> and <em>height</em> with a pachymeter. The dataset includes 518 instances labeled as <em><strong>Beckianum beckianum</strong></em> (28.8%), <em><strong>Dysopeas muibum</strong></em> (21.2%), <em><strong>Allopeas gracilis</strong></em> (9.7%), <em><strong>Leptinaria unilamellata </strong></em>(12%), and <em><strong>Subulina octona</strong></em> (28.3%).
description: http://arxiv.org/abs/2109.04903
DOI: 10.6084/m9.figshare.15000003.v1
title: AML employees Job satisfaction -Raw Data

description: This is a primary data obtained from bank employees of an Anti-Money laundering department in Malaysia based on Job diagnostics survey.<br>
DOI: 10.6084/m9.figshare.15000003
title: AML employees Job satisfaction -Raw Data

description: This is a primary data obtained from bank employees of an Anti-Money laundering department in Malaysia based on Job diagnostics survey.<br>
DOI: 10.6084/m9.figshare.15000003.v2
title: AML employees Job satisfaction -Raw Data

description: This is a primary data obtained from bank employees of an Anti-Money laundering department in Malaysia based on Job diagnostics survey.<br>
DOI: 10.5281/zenodo.5508683
title: Japanese Visual Media Graph - AnimeClick Ontology

description: This group of files represents the RDF ontology used in the Japanese Visual Media Graph for AnimeClick. Included in the upload are an explanatory PDF, the ontology in the Turtle serialization, and an HTML visualization of the ontology.
description: This work has been funded by Deutsche Forschungsgemeinschaft (German Research Foundation) with a grant from the funding program "e-Research Technologies".
DOI: 10.5281/zenodo.5036480
title: Japanese Visual Media Graph - AnimeClick Ontology

description: This group of files represents the RDF ontology used in the Japanese Visual Media Graph for AnimeClick. Included in the upload are an explanatory PDF, the ontology in the Turtle serialization, and an HTML visualization of the ontology.
description: This work has been funded by Deutsche Forschungsgemeinschaft (German Research Foundation) with a grant from the funding program "e-Research Technologies".
DOI: 10.25442/hku.16432935
title: Supporting data for "highly-accelerated multi-shot diffusion-weighted imaging and multi-echo functional magnetic resonance imaging"

description: The supporting data is the diffusion and functional dataset from healthy subjects involved in the results of thesis entitled "highly-accelerated multi-shot diffusion-weighted imaging and multi-echo functional magnetic resonance imaging". The datasets are comprised of three folders, which contains data for the study described in chapter 3 (IVIM), chapter 4 (DTI) and chapter 5 (ME-fMRI). The diffusion data were acquired on a 1.5T GE scanner and the functional data were acquired on a 3T GE scanner. The IVIM data were acquired using 4-shot EPI with 17 b-values and the DTI data were acquired using 4-shot EPI with 64 directions. The diffusion data are k-space data and can be read using MATLAB. The functional data were multi-echo fMRI images (nifti format) reconstructed from three reconstruction algorithms, including SENSE and two proposed novel reconstruction frameworks based on parametric POCSMUSE and MUSE.
DOI: 10.25442/hku.16435659
title: Supporting data for “Predictive Factors for Radiographic Outcomes and Cage Subsidence After Oblique Lateral Interbody Fusion“

description: Supporting data for chapter 4 in thesis named "Predictive Factors for Radiographic Outcomes and Cage Subsidence After Oblique Lateral Interbody Fusion" submitted by Hao Wu.<br>This dataset contains preoperative and early postoperative clinical parameters measured from MRI images from patients who underwent oblique lateral interbody fusion (OLIF).<br>From February 2015 to December 2019, 103 consecutive patients (206 levels) who underwent OLIF with or without posterior instrumentation fulfilled study inclusion criteria and were retrospectively studied. Radiographic variables measured pre- and postoperatively included (1) disc height, (2) segmental lordosis, (3) foraminal height and area, (4) the diameter of the bulging disc, (5) spinal canal diameter and area, (6) dural sac diameter and area, (7) left and right axial subarticular diameter, (8) left and right ligamentum flavum (LF) thickness, and (9) ligamentum flavum area.<br><br>
DOI: 10.25442/hku.16435659.v1
title: Supporting data for “Predictive Factors for Radiographic Outcomes and Cage Subsidence After Oblique Lateral Interbody Fusion“

description: Supporting data for chapter 4 in thesis named "Predictive Factors for Radiographic Outcomes and Cage Subsidence After Oblique Lateral Interbody Fusion" submitted by Hao Wu.<br>This dataset contains preoperative and early postoperative clinical parameters measured from MRI images from patients who underwent oblique lateral interbody fusion (OLIF).<br>From February 2015 to December 2019, 103 consecutive patients (206 levels) who underwent OLIF with or without posterior instrumentation fulfilled study inclusion criteria and were retrospectively studied. Radiographic variables measured pre- and postoperatively included (1) disc height, (2) segmental lordosis, (3) foraminal height and area, (4) the diameter of the bulging disc, (5) spinal canal diameter and area, (6) dural sac diameter and area, (7) left and right axial subarticular diameter, (8) left and right ligamentum flavum (LF) thickness, and (9) ligamentum flavum area.<br><br>
DOI: 10.5281/zenodo.5508686
title: Japanese Visual Media Graph - Anime Characters Database Ontology

description: This group of files represents the RDF ontology used in the Japanese Visual Media Graph for the Anime Characters Database. Included in the upload are an explanatory PDF, the ontology in the Turtle serialization, and an HTML visualization of the ontology.
description: This work has been funded by Deutsche Forschungsgemeinschaft (German Research Foundation) with a grant from the funding program "e-Research Technologies".
DOI: 10.6084/m9.figshare.13147324.v11
title: QMOF Database

description: This repository hosts the Quantum MOF (QMOF) database as described in: https://doi.org/10.1016/j.matt.2021.02.015.<br>IMPORTANT NOTE: Please check out the QMOF GitHub repository for a description of the files hosted here, supplemental scripts, and other related information:https://github.com/arosen93/QMOF. Additional tabulated and raw data can be accessed via the GitHub page!<br>This work was supported in part by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences through the Nanoporous Materials Genome Center under Award Number DE-FG02-17ER16362.
DOI: 10.25442/hku.16436100
title: Supporting data for "Neural Correlates of Contextually Modulated Depth Perception in Humans"

description: Dataset consists of data obtained from 3 experiments, organised in 3 separate folders. The first folder (Chapter 2) contains behavioural thresholds and neural responses obtained in depth tasks. Data are organised according to subtasks. The second folder (Chapter 3) contains behavioural thresholds and accuracies obtained during transcranial magnetic stimulation, data organised according to subtasks. The last folder (Chapter 4) contains behavioural thresholds and accuracies obtained in depth tasks, data organised accordingly.
DOI: 10.25442/hku.16431567
title: Supporting data for Time-integrated zircon trace element compositions as proxies for tracking crustal evolution

description: This dataset contains zircon U-Th-Pb isotopic and trace elements data analyzed by Ablation-Inductively Coupled Plasma Mass Spectrometry in both China and United States. Research region includes Mariana arc (Guam and Saipan), Indonesia (Bali), Thailand. Zircon were collected from modern sediments such as the river sands or beach sands, and the ancient sedimentary rocks to track the regional and global continental evolution.
DOI: 10.25442/hku.16431567.v1
title: Supporting data for Time-integrated zircon trace element compositions as proxies for tracking crustal evolution

description: This dataset contains zircon U-Th-Pb isotopic and trace elements data analyzed by Ablation-Inductively Coupled Plasma Mass Spectrometry in both China and United States. Research region includes Mariana arc (Guam and Saipan), Indonesia (Bali), Thailand. Zircon were collected from modern sediments such as the river sands or beach sands, and the ancient sedimentary rocks to track the regional and global continental evolution.
DOI: 10.25442/hku.16435578
title: Supporting data for "High throughput profiling of PA amino acid substitutions in an A(H1N1) pdm09 influenza virus that confers resistance to baloxavir in vitro"

description: All raw NGS data had been stored in an external location (Cloud Station Drive). This metadata record was generated to backup analyzed NGS data including: 1. relative fitness score of high confident mutants in single round passage and serial passage assay, 2. analysis result of mutations emerged in serial passage via full-length PA sequencing; 3, Mutant viruses sequencing results (including C1 and C2).
DOI: 10.25442/hku.16435578.v1
title: Supporting data for "High throughput profiling of PA amino acid substitutions in an A(H1N1) pdm09 influenza virus that confers resistance to baloxavir in vitro"

description: All raw NGS data had been stored in an external location (Cloud Station Drive). This metadata record was generated to backup analyzed NGS data including: 1. relative fitness score of high confident mutants in single round passage and serial passage assay, 2. analysis result of mutations emerged in serial passage via full-length PA sequencing; 3, Mutant viruses sequencing results (including C1 and C2).
DOI: 10.5517/ccdc.csd.cc24gn3d
title: CCDC 1980283: Experimental Crystal Structure Determination

description: Related Article: Pondchanok Chinapang, Hikaru Iwami, Takafumi Enomoto, Takuya Akai, Mio Kondo, Shigeyuki Masaoka|2021|Inorg.Chem.|60|12634|doi:10.1021/acs.inorgchem.1c01279
DOI: 10.5517/ccdc.csd.cc24gn4f
title: CCDC 1980284: Experimental Crystal Structure Determination

description: Related Article: Pondchanok Chinapang, Hikaru Iwami, Takafumi Enomoto, Takuya Akai, Mio Kondo, Shigeyuki Masaoka|2021|Inorg.Chem.|60|12634|doi:10.1021/acs.inorgchem.1c01279
DOI: 10.25442/hku.16437921
title: Supporting data for " Design and synthesis of α-aminoxy acid dipeptides as cation transporters and their applications as anti-bacterial agents "

description: Herein we attached the supporting data including the synthesis, chemical characterisation and the experiments regarding the antibacterial mechanism of novel aminoxy dipeptides. These aminoxy dipepides are active against <i>S. aureus</i> persister and biofilm by disrupting the ion homeostasis of the them.
DOI: 10.25442/hku.16437921.v1
title: Supporting data for " Design and synthesis of α-aminoxy acid dipeptides as cation transporters and their applications as anti-bacterial agents "

description: Herein we attached the supporting data including the synthesis, chemical characterisation and the experiments regarding the antibacterial mechanism of novel aminoxy dipeptides. These aminoxy dipepides are active against <i>S. aureus</i> persister and biofilm by disrupting the ion homeostasis of the them.
DOI: 10.25442/hku.16438650
title: Supporting data for "The role of B cells in the development of Sjögren's syndrome"

description: This study aims to identify the pathogenic B cell subset in ESS mice and pSS patients. Different methods including flow cytometric analysis, immunofluorescent staining, H&E staining, RNA-seq; ELISA; ELISpot are used. The dataset contains the required data of the results part in my thesis, which is ordered according to the chapter numbers: from chapter 3 to chapter 7. Moreover, the data of each section in the chapter with different types can be easily found since it has been well labeled.
DOI: 10.25442/hku.16438650.v1
title: Supporting data for "The role of B cells in the development of Sjögren's syndrome"

description: This study aims to identify the pathogenic B cell subset in ESS mice and pSS patients. Different methods including flow cytometric analysis, immunofluorescent staining, H&E staining, RNA-seq; ELISA; ELISpot are used. The dataset contains the required data of the results part in my thesis, which is ordered according to the chapter numbers: from chapter 3 to chapter 7. Moreover, the data of each section in the chapter with different types can be easily found since it has been well labeled.
DOI: 10.5281/zenodo.5508697
title: Japanese Visual Media Graph - Anime Characters Database Ontology

description: This group of files represents the RDF ontology used in the Japanese Visual Media Graph for the Anime Characters Database. Included in the upload are an explanatory PDF, the ontology in the Turtle serialization, and an HTML visualization of the ontology.
description: This work has been funded by Deutsche Forschungsgemeinschaft (German Research Foundation) with a grant from the funding program "e-Research Technologies".
DOI: 10.25442/hku.16441815
title: Supporting data for "Metagenomic Sequencing of Gut Microbiome and Antibiotic Resistance Genes after Antibiotics Therapy for Helicobacter pylori"

description: This dataset includes four folder: ARG dataset, virus dataset, fungi dataset, RPG presentations Folder1 includes datasets of ARGs, microbiota, ARG mechanism, metadata, and codes for statistical analysis and figure generation. Folder2 includes datasets of viruses, microbiota, metadata, and codes for statistical analysis and figure generation. Folder3 includes datasets of fungi, microbiota, metadata, and codes for statistical analysis and figure generation. Folder4 includes all the presentations in the department and international conference.
DOI: 10.25442/hku.16441815.v1
title: Supporting data for "Metagenomic Sequencing of Gut Microbiome and Antibiotic Resistance Genes after Antibiotics Therapy for Helicobacter pylori"

description: This dataset includes four folder: ARG dataset, virus dataset, fungi dataset, RPG presentations Folder1 includes datasets of ARGs, microbiota, ARG mechanism, metadata, and codes for statistical analysis and figure generation. Folder2 includes datasets of viruses, microbiota, metadata, and codes for statistical analysis and figure generation. Folder3 includes datasets of fungi, microbiota, metadata, and codes for statistical analysis and figure generation. Folder4 includes all the presentations in the department and international conference.
DOI: 10.5281/zenodo.5508699
title: Japanese Visual Media Graph - Anime Characters Database Ontology

description: This group of files represents the RDF ontology used in the Japanese Visual Media Graph for the Anime Characters Database. Included in the upload are an explanatory PDF, the ontology in the Turtle serialization, and an HTML visualization of the ontology.
description: This work has been funded by Deutsche Forschungsgemeinschaft (German Research Foundation) with a grant from the funding program "e-Research Technologies".
DOI: 10.25442/hku.16443876
title: Supporting data for “Greenhouse gas dynamics of the Pokfulam Reservoir catchment in Hong Kong”

description: This is the supporting data for the thesis “Greenhouse gas dynamics of the Pokfulam Reservoir catchment in Hong Kong”. This study focused on two major greenhouse gases (GHG), namely carbon dioxide and methane. <br> The folder consists of two files, which are the hydrochemical, GHG, and meteorological data of the Pokfulam Reservoir catchment and its headwater stream fed by groundwater collected on a monthly basis between 2020 and 2021 during the field campaign.
DOI: 10.25442/hku.16443876.v1
title: Supporting data for “Greenhouse gas dynamics of the Pokfulam Reservoir catchment in Hong Kong”

description: This is the supporting data for the thesis “Greenhouse gas dynamics of the Pokfulam Reservoir catchment in Hong Kong”. This study focused on two major greenhouse gases (GHG), namely carbon dioxide and methane. <br> The folder consists of two files, which are the hydrochemical, GHG, and meteorological data of the Pokfulam Reservoir catchment and its headwater stream fed by groundwater collected on a monthly basis between 2020 and 2021 during the field campaign.
DOI: 10.14457/cu.the.2019.109
title: ผลของการบริบาลเภสัชกรรมต่อการควบคุมระดับกลูโคสในเลือดของผู้ป่วยสูงอายุโรคเบาหวานชนิดที่ 2 ก่อนและหลังจำหน่ายออกจากโรงพยาบาล

description: วัตถุประสงค์: ศึกษาผลของการให้บริบาลเภสัชกรรมต่อการควบคุมระดับน้ำตาลในเลือด ผลลัพธ์ทางคลินิกและการลดปัญหาจากการใช้ยาในผู้ป่วยสูงอายุโรคเบาหวานชนิดที่ 2 วิธีการวิจัย: การวิจัยเชิงทดลองแบบสุ่มที่มีกลุ่มควบคุม กลุ่มตัวอย่างคือผู้ป่วยสูงอายุโรคเบาหวานชนิดที่ 2 แบ่งเป็นสองกลุ่มคือกลุ่มศึกษาและกลุ่มควบคุม กลุ่มละ 90 คน โดยจะติดตามและประเมินผู้ป่วยตั้งแต่เข้ารับการรักษาตัวในหอผู้ป่วยใน จนกระทั่งจำหน่ายออกจากโรงพยาบาลและมาติดตามการรักษา ณ แผนกผู้ป่วยนอก เป็นระยะเวลา 3 เดือน ผลลัพธ์ที่ติดตาม ได้แก่ การควบคุมระดับน้ำตาลในเลือด ผลลัพธ์ทางคลินิก สัดส่วนจำนวนคนที่พบปัญหาจากการใช้ยา และจำนวนปัญหาจากการใช้ยา ผลการวิจัย: เมื่อสิ้นสุดการศึกษาพบว่าผู้ป่วยกลุ่มศึกษามีค่าเฉลี่ย FPG ค่าเฉลี่ย HbA1C และค่าเฉลี่ยโลหิตลดลงเมื่อเทียบกับก่อนศึกษาและแตกต่างกับกลุ่มควบคุมอย่างมีนัยสำคัญทางสถิติ แต่ไม่มีผลต่อค่าระดับไขมันในเลือด ส่วนปัญหาการใช้ยาพบความชุกจำนวนคนที่พบปัญหาจากการใช้ยาสูงถึงร้อยละ 95 พบว่ากลุ่มที่ได้รับการบริบาลเภสัชกรรมมีการลดลงของสัดส่วนจำนวนคนที่พบปัญหาจากการใช้ยาและลดจำนวนปัญหาจากการใช้ยาได้อย่างมีนัยสำคัญทางสถิติ เมื่อเปรียบเทียบระหว่างกลุ่มศึกษาและกลุ่มควบคุมและสัดส่วนผู้ป่วยที่มีคะแนนพฤติกรรมการใช้ยามีแนวโน้มที่ดีขึ้นมีความสัมพันธ์กับการอยู่ในกลุ่มศึกษาอย่างมีนัยสำคัญทางสถิติ สรุปผลการวิจัย: จากผลการศึกษาจะเห็นว่าการบริบาลเภสัชกรรมมีส่วนช่วยให้ผู้ป่วยมีผลลัพธ์ทางคลินิกที่ดีขึ้นลดปัญหาจากการใช้ยาในผู้ป่วย และยังช่วยเพิ่มความร่วมมือในการใช้ยาของผู้ป่วยอีกด้วย
DOI: 10.14457/cu.the.2019.110
title: ความปลอดภัยของการบำบัดด้วยยาต้านเกล็ดเลือดสองชนิดร่วมกับยากลุ่มโปรตอนปั๊มอินฮิบิเตอร์ในผู้ป่วยกลุ่มอาการหลอดเลือดหัวใจตีบเฉียบพลันชาวไทย

description: ภาวะแทรกซ้อนต่อระบบทางเดินอาหาร เป็นอาการไม่พึงประสงค์ที่พบมากที่สุดจากการรักษาด้วยยาต้านเกล็ดเลือดร่วมกันสองชนิด (dual antiplatelet therapy; DAPT) จึงมีคำแนะนำการใช้ยายับยั้งการหลั่งกรดกลุ่ม proton pump inhibitors (PPIs) ร่วมด้วย เพื่อลดความเสี่ยงของการเกิดเหตุการณ์ไม่พึงประสงค์ต่อระบบทางเดินอาหารโดยเฉพาะอย่างยิ่งภาวะเลือดออกในทางเดินอาหาร อย่างไรก็ตามข้อมูลด้านความปลอดภัยและประสิทธิผลของการบำบัดด้วย DAPT ร่วมกับยายับยั้งการหลั่งกรดกลุ่ม PPIs ในผู้ป่วยชาวไทยยังมีไม่มาก การวิจัยนี้เป็นการวิจัยเชิงวิเคราะห์แบบเก็บข้อมูลย้อนหลัง เพื่อเปรียบเทียบความปลอดภัยและประสิทธิผลของการใช้ยาต้านเกล็ดเลือดสองชนิดร่วมกัน ระหว่างผู้ป่วยกลุ่มที่ได้รับ DAPT ร่วมกับยายับยั้งการหลั่งกรดกลุ่ม PPIs และกลุ่มที่ได้รับ DAPT เพียงอย่างเดียว ในผู้ป่วยภาวะหลอดเลือดหัวใจตีบเฉียบพลันและผู้ป่วยที่ได้รับการขยายหลอดเลือดหัวใจโคโรนารีโดยการสอดสายสวนผ่านทางผิวหนัง ณ สถาบันโรคทรวงอก ระหว่างเดือนมกราคม พ.ศ. 2559 ถึงเดือนธันวาคม พ.ศ. 2560 จำนวน 900 ราย ผลการศึกษาพบว่า ที่ระยะเวลา 24 เดือน ความเสี่ยงของการเกิดภาวะเลือดออกทางเดินอาหารของผู้ป่วยกลุ่มที่ได้รับ DAPT ร่วมกับยายับยั้งการหลั่งกรดกลุ่ม PPIs ลดลงร้อยละ 70 เมื่อเทียบกับผู้ป่วยกลุ่มที่ได้รับ DAPT เพียงอย่างเดียว (HR 0.30; 95% CI, 0.12 - 0.74; P=0.006) สำหรับอัตราการเกิดเหตุการณ์ไม่พึงประสงค์ต่อหัวใจและหลอดเลือดพบว่า ผู้ป่วยทั้งสองกลุ่มไม่มีความแตกต่างกันอย่างมีนัยสำคัญทางสถิติ โดยพบอุบัติการณ์การรักษาโดยการใส่ขดลวดขยายหลอดเลือดหัวใจซ้ำที่เส้นเดิม ในผู้ป่วยกลุ่มที่ได้รับ DAPT ร่วมกับยายับยั้งการหลั่งกรดกลุ่ม PPIs ร้อยละ 0.95 (P=0.214) แต่ไม่พบในกลุ่มที่ได้รับ DAPT เพียงอย่างเดียว ผลการวิจัยแสดงให้เห็นว่าการบำบัดด้วยยาต้านเกล็ดเลือดสองชนิดร่วมกับยายับยั้งการหลั่งกรดกลุ่ม PPIs สามารถลดอัตราการเกิดภาวะเลือดออกในระบบทางเดินอาหารได้ โดยการเกิดเหตุการณ์ไม่พึงประสงค์ทางหัวใจและหลอดเลือดไม่แตกต่างกัน โดยเฉพาะอย่างยิ่งในผู้ป่วยที่มีความเสี่ยงสูงต่อการเกิดภาวะเลือดออกในทางเดินอาหาร
DOI: 10.14457/cu.the.2018.469
title: Effect of ercc1, xrcc1 and gstp1 polymorphisms on clinical response and adverse events of platinum-based chemotherapy in epithelial ovarian cancer patients

description: Platinum-based chemotherapy is the first line chemotherapy regimen for epithelial ovarian cancer (EOC). Pharmacogenomics is one factor that might affect its efficacy and toxicity. This cohort study was aimed to investigate the association between ERCC1, XRCC1 and GSTP1 polymorphisms on clinical responses and adverse events related to platinum-based chemotherapy in Thai EOC patients. Fifty-two patients with advanced EOC were enrolled in this cohort study. The mean age was 55.7 years old. Genotyping analysis of ERCC1 (C&gt;A, rs3212986), XRCC1 (A&gt;G, rs25487) and GSTP (A&gt;G, rs1695) were performed which allele frequencies were found at 35.6%, 28.9% and 10.6%, respectively. Neither of them associated with clinical responses. However, patients with homozygous variant type (A/A) of ERCC1 C8092A had higher risk of platinum-resistance (75% vs 16.7%, P = 0.046). In addition, the significant association of GSTP1 polymorphism and grade 2 anemia was found. Patients with A/G genotype of GSTP1 had higher rate of grade 2 anemia than those with wild type (81.8% vs 46.3%, P = 0.036). Genetic polymorphisms of ERCC1 and GSTP1 might be advantageous biomarkers to predicting clinical response and toxicity of platinum-based chemotherapy in Thai EOC patients.