cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6383117
title: Supplementary Material for: Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer’s Disease Mice

description: <b><i>Background/Aims:</i></b> Decreasing levels of aromatase and seladin-1 could be one of the molecular mechanisms of Alzheimer’s disease (AD). Aromatase is an enzyme that catalyzes estrogen biosynthesis from androgen precursors, and seladin-1 is an enzyme that converts desmosterol to cholesterol, which is the precursor of all hormones. Verifying the potential relationship between these proteins and accordingly determining new therapeutic targets constitute the aims of this study. <b><i>Methods:</i></b> Changes in protein levels were compared in vitro in aromatase and seladin-1 inhibitor-administered human neuroblastoma (SH-SY5Y) cells in vivo in intracerebroventricular (icv) aromatase or seladin-1 inhibitor-administered rats, as well as in transgenic AD mice in which the genes encoding these proteins were knocked out. <b><i>Results and Conclusions:</i></b> In the cell cultures, we observed that seladin-1 protein levels increased after aromatase enzyme inhibition. The hippocampal aromatase protein levels decreased following chronic seladin-1 inhibition in icv inhibitor-administered rats; however, the aromatase levels in the dentate gyrus of seladin-1 knockout (SelKO) AD male mice increased. These findings indicate a partial relationship between these proteins and their roles in AD pathology.
DOI: 10.6084/m9.figshare.6383117.v1
title: Supplementary Material for: Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer’s Disease Mice

description: <b><i>Background/Aims:</i></b> Decreasing levels of aromatase and seladin-1 could be one of the molecular mechanisms of Alzheimer’s disease (AD). Aromatase is an enzyme that catalyzes estrogen biosynthesis from androgen precursors, and seladin-1 is an enzyme that converts desmosterol to cholesterol, which is the precursor of all hormones. Verifying the potential relationship between these proteins and accordingly determining new therapeutic targets constitute the aims of this study. <b><i>Methods:</i></b> Changes in protein levels were compared in vitro in aromatase and seladin-1 inhibitor-administered human neuroblastoma (SH-SY5Y) cells in vivo in intracerebroventricular (icv) aromatase or seladin-1 inhibitor-administered rats, as well as in transgenic AD mice in which the genes encoding these proteins were knocked out. <b><i>Results and Conclusions:</i></b> In the cell cultures, we observed that seladin-1 protein levels increased after aromatase enzyme inhibition. The hippocampal aromatase protein levels decreased following chronic seladin-1 inhibition in icv inhibitor-administered rats; however, the aromatase levels in the dentate gyrus of seladin-1 knockout (SelKO) AD male mice increased. These findings indicate a partial relationship between these proteins and their roles in AD pathology.
DOI: 10.6084/m9.figshare.6383090
title: Supplementary Material for: Target Door-to-Needle Time for Tissue Plasminogen Activator Treatment with Magnetic Resonance Imaging Screening Can Be Reduced to 45 min

description: <b><i>Objective:</i></b> The purpose of this study was to demonstrate that the median door-to-needle (DTN) time for intravenous tissue plasminogen activator (tPA) treatment can be reduced to 45 min in a primary stroke centre with MRI-based screening for acute ischaemic stroke (AIS). <b><i>Methods:</i></b> From February 2015 to February 2017, the stroke unit of Perpignan general hospital, France, implemented a quality-improvement (QI) process. During this period, patients who received tPA within 4.5 h after AIS onset were included in the QI cohort. Their clinical characteristics and timing metrics were compared each semester and also with those of 135 consecutive patients with AIS treated by tPA during the 1-year pre-QI period (pre-QI cohort). <b><i>Results:</i></b> In the QI cohort, 274 patients (92.5%) underwent MRI screening. While the demographic and baseline characteristics were not significantly different between cohorts, the median DTN time was significantly lower in the QI than in the pre-QI cohort (52 vs. 84 min; <i>p</i> &lt; 0.00001). Within the QI cohort, the median DTN time for each semester decreased from 65 to 44 min (<i>p</i> &lt; 0.00001) and the proportion of treated patients with a DTN time ≤45 min increased from 25 to 58.9% (<i>p</i> &lt; 0.0001). Overall, DTN time improvement was associated with a better outcome at 3 months (patients with a modified Rankin Scale score between 0 and 2: 61.8% in the QI vs. 39.3% in the pre-QI cohort; <i>p</i> &lt; 0.0001). <b><i>Conclusions:</i></b> A QI process can reduce the DTN within 45 min with MRI as a screening tool.
DOI: 10.6084/m9.figshare.6383090.v1
title: Supplementary Material for: Target Door-to-Needle Time for Tissue Plasminogen Activator Treatment with Magnetic Resonance Imaging Screening Can Be Reduced to 45 min

description: <b><i>Objective:</i></b> The purpose of this study was to demonstrate that the median door-to-needle (DTN) time for intravenous tissue plasminogen activator (tPA) treatment can be reduced to 45 min in a primary stroke centre with MRI-based screening for acute ischaemic stroke (AIS). <b><i>Methods:</i></b> From February 2015 to February 2017, the stroke unit of Perpignan general hospital, France, implemented a quality-improvement (QI) process. During this period, patients who received tPA within 4.5 h after AIS onset were included in the QI cohort. Their clinical characteristics and timing metrics were compared each semester and also with those of 135 consecutive patients with AIS treated by tPA during the 1-year pre-QI period (pre-QI cohort). <b><i>Results:</i></b> In the QI cohort, 274 patients (92.5%) underwent MRI screening. While the demographic and baseline characteristics were not significantly different between cohorts, the median DTN time was significantly lower in the QI than in the pre-QI cohort (52 vs. 84 min; <i>p</i> &lt; 0.00001). Within the QI cohort, the median DTN time for each semester decreased from 65 to 44 min (<i>p</i> &lt; 0.00001) and the proportion of treated patients with a DTN time ≤45 min increased from 25 to 58.9% (<i>p</i> &lt; 0.0001). Overall, DTN time improvement was associated with a better outcome at 3 months (patients with a modified Rankin Scale score between 0 and 2: 61.8% in the QI vs. 39.3% in the pre-QI cohort; <i>p</i> &lt; 0.0001). <b><i>Conclusions:</i></b> A QI process can reduce the DTN within 45 min with MRI as a screening tool.
DOI: 10.6084/m9.figshare.6383042
title: The role of adaptive strategies in plant naturalization

description: 3004 species with information of Pierce et al. CSR scores, presence in the GloNAF database, GlonAF regions, etc.<br>Guo W-Y, van Kleunen M, Winter M, Weigelt P, Stein A, Pierce S, Pergl J Moser D, Maurel N, Lenzner B, Kreft H, Essl F, Dawson W & Pyšek P (2018) The role of adaptive strategies in plant naturalization. Ecology Letters, doi: 10.1111/ele.13104<br>
DOI: 10.6084/m9.figshare.6383042.v2
title: The role of adaptive strategies in plant naturalization

description: 3004 species with information of Pierce et al. CSR scores, presence in the GloNAF database, GlonAF regions, etc.<br>Guo W-Y, van Kleunen M, Winter M, Weigelt P, Stein A, Pierce S, Pergl J Moser D, Maurel N, Lenzner B, Kreft H, Essl F, Dawson W & Pyšek P (2018) The role of adaptive strategies in plant naturalization. Ecology Letters, doi: 10.1111/ele.13104<br>
DOI: 10.6084/m9.figshare.6383042.v1
title: The role of adaptive strategies in plant naturalization

description: 3004 species with information of Pierce et al. CSR scores, presence in the GloNAF database, GlonAF regions, etc.<br>Guo W-Y, van Kleunen M, Winter M, Weigelt P, Stein A, Pierce S, Pergl J Moser D, Maurel N, Lenzner B, Kreft H, Essl F, Dawson W & Pyšek P (2018) The role of adaptive strategies in plant naturalization. Ecology Letters, doi: 10.1111/ele.13104<br>
DOI: 10.6084/m9.figshare.6382709
title: A Relative Phase based Audio Integrity Protection Method-Model and Strategy

description: Some available data
DOI: 10.6084/m9.figshare.6382709.v1
title: A Relative Phase based Audio Integrity Protection Method-Model and Strategy

description: Some available data
DOI: 10.6084/m9.figshare.6382391
title: Not a powerful electoral issue yet: on the role of European integration in the 2017 German federal election

description: This article explores the role of European integration in affecting voting behaviour in the 2017 German federal election. Building on a theoretical analysis of EU issue voting, it demonstrates that despite a list of issues on the European agenda, EU-related issues did not play a prominent role in the campaign, nor were issues primarily addressed from a European perspective. Relying on survey data collected before and after the election, the analysis demonstrates that voters perceived parties to differ considerably on EU integration, but they did not care much about it. Attitudes towards European integration and financial aid to EU member states were only mildly related to vote choice in the 2017 election. European integration thus has not yet become a powerful political issue in Germany. The paper concludes by discussing implications for EU issue voting in future German elections.
DOI: 10.6084/m9.figshare.6382391.v1
title: Not a powerful electoral issue yet: on the role of European integration in the 2017 German federal election

description: This article explores the role of European integration in affecting voting behaviour in the 2017 German federal election. Building on a theoretical analysis of EU issue voting, it demonstrates that despite a list of issues on the European agenda, EU-related issues did not play a prominent role in the campaign, nor were issues primarily addressed from a European perspective. Relying on survey data collected before and after the election, the analysis demonstrates that voters perceived parties to differ considerably on EU integration, but they did not care much about it. Attitudes towards European integration and financial aid to EU member states were only mildly related to vote choice in the 2017 election. European integration thus has not yet become a powerful political issue in Germany. The paper concludes by discussing implications for EU issue voting in future German elections.
DOI: 10.6084/m9.figshare.6382370
title: Synthesis of 1,1′-(2,6-dihydroxy-2,6-dimethyl-3,7-dioxabicyclo [3.3.1]nonane-1,5-diyl)diethanone dihydrate: crystal structure and quantitative analysis of molecular interaction <i>via</i> molecular electrostatic potential and Hirshfeld surface analysis

description: A new bicyclononane derivative, 1,1′-(2,6-dihydroxy-2,6-dimethyl-3,7-dioxa-bicyclo[3.3.1]nonane-1,5-diyl) diethanone dihydrate (<b>1</b>), has been synthesized and structurally characterized by the single-crystal X-ray diffraction technique. In the solid-state structure of the compound, molecular units are interlinked <i>via</i> strong hydrogen bonds as well as non-classical weak hydrogen bonds leading to a three-dimensional supramolecular architecture. Solid-state DFT optimized geometry in (<b>1</b>) agrees closely with that obtained from the crystallographic analysis. The C(dioxa-bicyclononane)–H … O(hydroxy) hydrogen bond generates cyclic R22 (10) ring in (<b>1</b>) which are further connected through C–H … O and O–H … O hydrogen bonds into a three-dimensional framework in the title compound. Hirshfeld surface analysis of the title compound along with some related nonane derivatives retrieved from the Cambridge Structural Database shows that the most of the Hirshfeld surface area in this class of compounds is due to H … H and O … H interactions.
DOI: 10.6084/m9.figshare.6382370.v1
title: Synthesis of 1,1′-(2,6-dihydroxy-2,6-dimethyl-3,7-dioxabicyclo [3.3.1]nonane-1,5-diyl)diethanone dihydrate: crystal structure and quantitative analysis of molecular interaction <i>via</i> molecular electrostatic potential and Hirshfeld surface analysis

description: A new bicyclononane derivative, 1,1′-(2,6-dihydroxy-2,6-dimethyl-3,7-dioxa-bicyclo[3.3.1]nonane-1,5-diyl) diethanone dihydrate (<b>1</b>), has been synthesized and structurally characterized by the single-crystal X-ray diffraction technique. In the solid-state structure of the compound, molecular units are interlinked <i>via</i> strong hydrogen bonds as well as non-classical weak hydrogen bonds leading to a three-dimensional supramolecular architecture. Solid-state DFT optimized geometry in (<b>1</b>) agrees closely with that obtained from the crystallographic analysis. The C(dioxa-bicyclononane)–H … O(hydroxy) hydrogen bond generates cyclic R22 (10) ring in (<b>1</b>) which are further connected through C–H … O and O–H … O hydrogen bonds into a three-dimensional framework in the title compound. Hirshfeld surface analysis of the title compound along with some related nonane derivatives retrieved from the Cambridge Structural Database shows that the most of the Hirshfeld surface area in this class of compounds is due to H … H and O … H interactions.
DOI: 10.6084/m9.figshare.6382367
title: Data-related challenges and solutions in building China’s national carbon emissions trading scheme

description: China is now in the process of building its national carbon emissions trading scheme (ETS). Data are the foundation for the design and operation of an ETS. This paper presents a comparative analysis of the data requirements for China’s national ETS construction and the existing ETS-related data for enterprises in China. In doing so, it identifies the underlying data gap in building China’s national ETS in terms of data availability and data quality. Based on the experiences of international ETSs, and experiences at national and pilot levels in China, we propose two short-term strategies and four long-term solutions to meet the challenges from technical and management perspectives. <b>Key policy insights</b>The major data requirements for China’s national ETS can be categorized into six groups: production, emissions, technology, management, economy and policy data.The ETS-related data are generally available in China except for parts of data on emissions, such as energy carbon content and the oxidation factor.The data challenges that are faced by China’s national ETS include differences in corporate data availability and imperfect data quality.Short-term strategies to address the challenges include establishing data collection guidelines based on existing data and prioritizing major emissions or sectors with better data for inclusion under the ETS.Long-term solutions to address the challenges include introducing the concept of tiers, clarifying data sources and introducing a monitoring plan, conducting MRV capacity building and establishing a rigorous third-party verification system. The major data requirements for China’s national ETS can be categorized into six groups: production, emissions, technology, management, economy and policy data. The ETS-related data are generally available in China except for parts of data on emissions, such as energy carbon content and the oxidation factor. The data challenges that are faced by China’s national ETS include differences in corporate data availability and imperfect data quality. Short-term strategies to address the challenges include establishing data collection guidelines based on existing data and prioritizing major emissions or sectors with better data for inclusion under the ETS. Long-term solutions to address the challenges include introducing the concept of tiers, clarifying data sources and introducing a monitoring plan, conducting MRV capacity building and establishing a rigorous third-party verification system.
DOI: 10.6084/m9.figshare.6382367.v2
title: Data-related challenges and solutions in building China’s national carbon emissions trading scheme

description: China is now in the process of building its national carbon emissions trading scheme (ETS). Data are the foundation for the design and operation of an ETS. This paper presents a comparative analysis of the data requirements for China’s national ETS construction and the existing ETS-related data for enterprises in China. In doing so, it identifies the underlying data gap in building China’s national ETS in terms of data availability and data quality. Based on the experiences of international ETSs, and experiences at national and pilot levels in China, we propose two short-term strategies and four long-term solutions to meet the challenges from technical and management perspectives. <b>Key policy insights</b>The major data requirements for China’s national ETS can be categorized into six groups: production, emissions, technology, management, economy and policy data.The ETS-related data are generally available in China except for parts of data on emissions, such as energy carbon content and the oxidation factor.The data challenges that are faced by China’s national ETS include differences in corporate data availability and imperfect data quality.Short-term strategies to address the challenges include establishing data collection guidelines based on existing data and prioritizing major emissions or sectors with better data for inclusion under the ETS.Long-term solutions to address the challenges include introducing the concept of tiers, clarifying data sources and introducing a monitoring plan, conducting MRV capacity building and establishing a rigorous third-party verification system. The major data requirements for China’s national ETS can be categorized into six groups: production, emissions, technology, management, economy and policy data. The ETS-related data are generally available in China except for parts of data on emissions, such as energy carbon content and the oxidation factor. The data challenges that are faced by China’s national ETS include differences in corporate data availability and imperfect data quality. Short-term strategies to address the challenges include establishing data collection guidelines based on existing data and prioritizing major emissions or sectors with better data for inclusion under the ETS. Long-term solutions to address the challenges include introducing the concept of tiers, clarifying data sources and introducing a monitoring plan, conducting MRV capacity building and establishing a rigorous third-party verification system.
DOI: 10.6084/m9.figshare.6382367.v1
title: Data-related challenges and solutions in building China’s national carbon emissions trading scheme

description: China is now in the process of building its national carbon emissions trading scheme (ETS). Data are the foundation for the design and operation of an ETS. This paper presents a comparative analysis of the data requirements for China’s national ETS construction and the existing ETS-related data for enterprises in China. In doing so, it identifies the underlying data gap in building China’s national ETS in terms of data availability and data quality. Based on the experiences of international ETSs, and experiences at national and pilot levels in China, we propose two short-term strategies and four long-term solutions to meet the challenges from technical and management perspectives. <b>Key policy insights</b>The major data requirements for China’s national ETS can be categorized into six groups: production, emissions, technology, management, economy and policy data.The ETS-related data are generally available in China except for parts of data on emissions, such as energy carbon content and the oxidation factor.The data challenges that are faced by China’s national ETS include differences in corporate data availability and imperfect data quality.Short-term strategies to address the challenges include establishing data collection guidelines based on existing data and prioritizing major emissions or sectors with better data for inclusion under the ETS.Long-term solutions to address the challenges include introducing the concept of tiers, clarifying data sources and introducing a monitoring plan, conducting MRV capacity building and establishing a rigorous third-party verification system. The major data requirements for China’s national ETS can be categorized into six groups: production, emissions, technology, management, economy and policy data. The ETS-related data are generally available in China except for parts of data on emissions, such as energy carbon content and the oxidation factor. The data challenges that are faced by China’s national ETS include differences in corporate data availability and imperfect data quality. Short-term strategies to address the challenges include establishing data collection guidelines based on existing data and prioritizing major emissions or sectors with better data for inclusion under the ETS. Long-term solutions to address the challenges include introducing the concept of tiers, clarifying data sources and introducing a monitoring plan, conducting MRV capacity building and establishing a rigorous third-party verification system.
DOI: 10.6084/m9.figshare.6381860
title: MOESM6 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 6. Peak data from ChIP-Seq and MBD-Seq experiments. Peaks from H3K27ac ChIP-Seq and MBD-Seq are presented in BED format. Note that due to file restrictions, MBD-Seq data for CFU-MK is included across two workbooks.
DOI: 10.6084/m9.figshare.6381860.v1
title: MOESM6 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 6. Peak data from ChIP-Seq and MBD-Seq experiments. Peaks from H3K27ac ChIP-Seq and MBD-Seq are presented in BED format. Note that due to file restrictions, MBD-Seq data for CFU-MK is included across two workbooks.
DOI: 10.6084/m9.figshare.6381854
title: MOESM5 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 5. Peak data from ATAC-Seq experiments. The presence of ATAC-Seq peaks in each cell type is indicated by a 1 (present) or 0 (not present).
DOI: 10.6084/m9.figshare.6381854.v1
title: MOESM5 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 5. Peak data from ATAC-Seq experiments. The presence of ATAC-Seq peaks in each cell type is indicated by a 1 (present) or 0 (not present).
DOI: 10.6084/m9.figshare.6381836
title: MOESM4 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 4. RNA-Seq data with TPM calculations. Transcripts per million counts are included for each RNA-Seq replicate.
DOI: 10.6084/m9.figshare.6381836.v1
title: MOESM4 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 4. RNA-Seq data with TPM calculations. Transcripts per million counts are included for each RNA-Seq replicate.
DOI: 10.6084/m9.figshare.6381815
title: MOESM3 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 3. Enrichment scores of transcription factor binding sites in AREs. Unabridged list of enriched transcription factor binding sites in AREs. Scores are reported as q-values.
DOI: 10.6084/m9.figshare.6381815.v1
title: MOESM3 of Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

description: Additional file 3. Enrichment scores of transcription factor binding sites in AREs. Unabridged list of enriched transcription factor binding sites in AREs. Scores are reported as q-values.