cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/nh3cvm3m3p.1
title: A novel form of macropinocytosis mediates ultra-rapid transfer of pathological alpha-synuclein to lysosomes

description: A key question in PD research relates to the mechanism by which alpha-synuclein (α-syn) fibrils enter cells. It is generally thought that α-syn preformed fibrils (PFF), a toxic form of α-syn, are trafficked to lysosomes through the endosomal system over the course of hours, although many conflicting results exist in the literature. We believe that some of the conflicting evidence arises from examining α-syn internalization at longer time courses and not immediately after its addition to cells. We also believe that dynamin inhibition, employed in many studies to inhibit PFF internalization, should not be treated as synonymous with inhibition of clathrin-mediated endocytosis (CME), as the role of dynamin spans beyond CME and is involved in multiple endocytic pathways and actin polymerization. We thus sought to examine PFF endocytosis immediately after its addition to cells. Remarkably, PFF are internalized rapidly and appear in lysosomes within 2 min, completely bypassing conventional endosomal trafficking pathways. We confirmed this result in multiple cell lines, primary human cells, and neurons derived from human induced pluripotent stem cells (hiPSC). The internalization is not dependent on clathrin but instead utilizes macropinocytosis.

All the raw data collected in our manuscript, has been organized and included in the .xlsx file attached. Additionally, the statistical calculations computed, with the use of Prism (graphpad.com) have also been included.
DOI: 10.17632/2rpcmmmx53.2
title: Cortical responses under threat in victms of urban violence: EEG dataset acquired during a choice reaction time task.

description: Dataset of brazilian participants (University Students), victms of urban violence. The sample consist of 38 participants [32 women; age, Mean (M)= 20.46 years; Standard Deviation (SD)= 2.06 years] who were divided into a high PTSD symptom severity group (high PTSS; who scored 44 or above on the PCL-C; M PTSS = 55.05; n = 17, 16 women), and a low PTSD symptoms severity group (low PTSS; who scored below 44; M PTSS = 28.14; n = 21, 16 women). The PTSS scores ranged from 17 to 77 (M PTSS = 40.18, SD = 16.37). 
The study investigated motor cortical activity triggered by a discrimination task. Participants were instructed to compare the orientation of two peripheral bars and to respond by pressing a key with their left or right hand while ignoring a central distractive picture. The picture could depict either a scene with mutilated bodies or a neutral scene.
Electrophysiological data were recorded from the scalp using a 23-channel EEG system (BrainNet BNT-36; EMSA Equipamentos Médicos Ltd., Rio de Janeiro, Brazil) that was positioned according to the electrode sites from the 10–20 system. We performed event-related potential and time frequency analyses to obtain the  the lateralized readiness potential (LRP) and the motor-related amplitude asymmetry (MRAA) in the alpha frequency range. 
The dataset contain: 
1) A .xls table containing infomation about the participants, such as gender, PTSS scores,  behavioral (reaction time)  and processed EEG data (MRAA amplitude and LRP latency). 
2) the preprocessed EEG data of the participants (.set files from EEGlab).
DOI: 10.17632/mg38whggpj.1
title: Immunohistochemical results of keloid

description:  Keloid. Immunohistochemical staining was carried out using CD4 antibody, CD68 antibody, IL-1β antibody, IL-6 antibody, E-selectin antibody, VCAM-1 antibody and visualized by a standard streptavidin biotin horseradish peroxidase technique. Scale bar:100 μm.
DOI: 10.6084/m9.figshare.7840889.v1
title: Supplementary table 1.pdf

description: Detailed conflicts of interest for JLS
DOI: 10.6084/m9.figshare.7840793
title: Biomarkers Marathon

description: marathon, ultramarathon, biomarkers
DOI: 10.6084/m9.figshare.7840760
title: IL1b_UrineProteomics_SupplementalTables

description: Supplemental Tables S1 (BCA protein normalization assay) and S2 (proteomic results) from the publication:<br><i>Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling</i><br><i></i>
DOI: 10.6084/m9.figshare.7838156
title: HT-smFRET datasets and analysis files

description: Single-molecule FRET datasets and analysis files associated with the article "High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins" by M. Segal et al.
DOI: 10.6084/m9.figshare.7837964
title: Supplementary Material 5 The expression changes of the 84 new transcripts in the two stages (unfertilized egg and prim-5).xlsx

description: The expression changes of the 84 new transcripts in the two stages (unfertilized egg and prim-5).
DOI: 10.6084/m9.figshare.7837973
title: Supplementary Material 6 The 38 transcripts that were matched to the datasets obtained by Nudelman et al. (Nudelman et al. 2018).xlsx

description: The 38 transcripts that were matched to the datasets obtained by Nudelman et al. (Nudelman et al. 2018).
DOI: 10.6084/m9.figshare.7838156.v1
title: HT-smFRET datasets and analysis files

description: Single-molecule FRET datasets and analysis files associated with the article "High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins" by M. Segal et al.
DOI: 10.6084/m9.figshare.7837952
title: Supplementary Material 4 The protein-coding potentials of the 84 new transcripts.xlsx

description: The protein-coding potentials of the 84 new transcripts.
DOI: 10.6084/m9.figshare.7837973.v2
title: Supplementary Material 6 The 38 transcripts that were matched to the datasets obtained by Nudelman et al. (Nudelman et al. 2018).xlsx

description: The 38 transcripts that were matched to the datasets obtained by Nudelman et al. (Nudelman et al. 2018).
DOI: 10.6084/m9.figshare.7837952.v2
title: Supplementary Material 4 The protein-coding potentials of the 84 new transcripts.xlsx

description: The protein-coding potentials of the 84 new transcripts.
DOI: 10.6084/m9.figshare.7837973.v1
title: Supplementary Material 6 The 38 transcripts that were matched to the datasets obtained by Nudelman et al. (Nudelman et al. 2018).

description: The 38 transcripts that were matched to the datasets obtained by Nudelman et al. (Nudelman et al. 2018).
DOI: 10.6084/m9.figshare.7837946
title: Supplementary Material 3 The annotations of the 84 new transcript.xlsx

description: The annotations of the 84 new transcript.
DOI: 10.6084/m9.figshare.7837952.v1
title: Supplementary Material 4 The protein-coding potentials of the 84 new transcripts.

description: The protein-coding potentials of the 84 new transcripts.
DOI: 10.6084/m9.figshare.7840760.v1
title: IL1b_UrineProteomics_SupplementalTables

description: Supplemental Tables S1 (proteomic results) and S2 (BCA protein normalization assay) from the publication:<br><i>Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling</i><br><i></i>
DOI: 10.17028/rd.lboro.7837940
title: The DEFACTO Field Trial: Methodology and Data Sets

description: The DEFACTO Field Trial was undertaken as part of a 6-year EPSRC-funded research project (grant EP/K00249X/1) from 1 November 2012 to 31 October 2018, aimed at measuring the energy saving capability of so-called ‘smart’ heating controls when used with gas-fired, low-pressure hot water central heating systems. This report describes the conduct of the field trial, the methodology adopted for its execution, the data that were collected and the cleaning of those data. Materials used in the field trial are presented in Appendix A (Pilot Study) and Appendix B (Main Study) to this report.
DOI: 10.6084/m9.figshare.7837964.v1
title: Supplementary Material 5 The expression changes of the 84 new transcripts in the two stages (unfertilized egg and prim-5).

description: The expression changes of the 84 new transcripts in the two stages (unfertilized egg and prim-5).
DOI: 10.6084/m9.figshare.7837931
title: Supplementary Material 2 The sequences of the 84 new transcripts.fa

description: The sequences of the 84 new transcripts.
DOI: 10.6084/m9.figshare.7837946.v2
title: Supplementary Material 3 The annotations of the 84 new transcript.xlsx

description: The annotations of the 84 new transcript.
DOI: 10.6084/m9.figshare.7840760.v4
title: IL1b_UrineProteomics_SupplementalTables

description: Supplemental Tables S1 (BCA protein normalization assay) and S2 (proteomic results) from the publication:<br><i>Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling</i><br><i></i>
DOI: 10.6084/m9.figshare.7837946.v1
title: Supplementary Material 3 The annotations of the 84 new transcript

description: The annotations of the 84 new transcript.
DOI: 10.6084/m9.figshare.7840760.v3
title: IL1b_UrineProteomics_SupplementalTables

description: Supplemental Tables S1 (proteomic results) and S2 (BCA protein normalization assay) from the publication:<br><i>Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling</i><br><i></i>
DOI: 10.6084/m9.figshare.7837865
title: Supplementary Material 1 The specific primer pairs of the 84 new transcripts.xlsx

description: The specific primer pairs of the 84 new transcripts.
DOI: 10.6084/m9.figshare.7837796
title: VAMS combine with molex-Flu to measure the influenza virus specific antibodies

description: Recently, volumetric absorptive microsampling (VAMS) has been used for peripheral blood sampling and analyses in several fields. VAMS ensures accurate sampling by collecting a fixed blood volume (10 or 20 $\mu$L) on a volumetric swab in blood spot format, and allows for long-term sample storage. The mPlex-Flu assay is a novel, multidimensional assay that measures the concentration of antibodies against multiple influenza virus simultaneously strains with a small volume of serum (less than 5 $\mu$L). Here we describe combining these two methods to measure multidimensional influenza antibody activity using a finger-stick and VAMS. In this study, we compared influenza antibody profiles measured from capillary blood obtained with a finger-stick, and venous whole blood collected by traditional phlebotomy from 20 subjects using the mPlex-Flu assay. We found that results with the two sampling methods were virtually identical across all influenza strains within the same subject (mean of $R^2$ =0.9470), and that antibodies remained stable over three weeks when VAMS samples were stored at room temperature and transported using a variety of shipping methods. Additionally, VAMS sampling is an easy and highly reproducible process; when volunteers performed finger stick VAMS at home by themselves, the comparison results of anti-HA antibody concentrations showed that they are highly consistent with sampling performed by study personnel on-site ($R^2$ =0.9496). This novel approach provides advantages for clinical influenza vaccine studies, including ease of sampling, low cost, and high accuracy. We conclude that these methods could provide an accurate and low-cost means for monitoring the influenza virus antibody responses in large population studies.
DOI: 10.6084/m9.figshare.7837748
title: Scale up supply of experimental Ebola drugs

description: The supplementary information and excel-based calculator tool to accompany the Nature Worldview titled "Scale up the supply of experimental Ebola drugs".
DOI: 10.6084/m9.figshare.7837748.v1
title: Scale up supply of experimental Ebola drugs

description: The supplementary information and excel-based calculator tool to accompany the Nature Worldview titled "Scale up the supply of experimental Ebola drugs".
DOI: 10.6084/m9.figshare.7837796.v1
title: VAMS combine with molex-Flu to measure the influenza virus specific antibodies

description: Recently, volumetric absorptive microsampling (VAMS) has been used for peripheral blood sampling and analyses in several fields. VAMS ensures accurate sampling by collecting a fixed blood volume (10 or 20 $\mu$L) on a volumetric swab in blood spot format, and allows for long-term sample storage. The mPlex-Flu assay is a novel, multidimensional assay that measures the concentration of antibodies against multiple influenza virus simultaneously strains with a small volume of serum (less than 5 $\mu$L). Here we describe combining these two methods to measure multidimensional influenza antibody activity using a finger-stick and VAMS. In this study, we compared influenza antibody profiles measured from capillary blood obtained with a finger-stick, and venous whole blood collected by traditional phlebotomy from 20 subjects using the mPlex-Flu assay. We found that results with the two sampling methods were virtually identical across all influenza strains within the same subject (mean of $R^2$ =0.9470), and that antibodies remained stable over three weeks when VAMS samples were stored at room temperature and transported using a variety of shipping methods. Additionally, VAMS sampling is an easy and highly reproducible process; when volunteers performed finger stick VAMS at home by themselves, the comparison results of anti-HA antibody concentrations showed that they are highly consistent with sampling performed by study personnel on-site ($R^2$ =0.9496). This novel approach provides advantages for clinical influenza vaccine studies, including ease of sampling, low cost, and high accuracy. We conclude that these methods could provide an accurate and low-cost means for monitoring the influenza virus antibody responses in large population studies.
DOI: 10.25375/uct.7837673
title: The role of selection in shaping the cranio-mandibular morphology of Paranthropus

description: This dataset contains 95th percentile values from frequency distributions of Mahalanobis’ distances (D2) calculated from extant hominoid models for each analysis used in the study. These values are used to evaluate the significance of the D2 values between fossil specimens. If D2 values are greater than the values presented in this table, then it is classified as statistically significant. Bolded red values indicate distances that are statistically significant compared to all of the 95% values from frequency distributions of Mahalanobis' distances calculated between extant hominoid models. Non-bolded red values indicate distances that are significant for at least one model.
DOI: 10.6084/m9.figshare.7837694
title: Liolaemus Cristiani eating a Vanessa Carye

description: Liolaemus Cristiani was described by Nuñez et al. [1] in 1991. It is endemic of the Andean Mountains, in the center area of Chile. There are records of it in the Región de O'Higgins and the Región del Maule, between the 2,000 and 2,500 meters above sea level. In this archive item, we provide multimedia records of a specimen eating a butterfly (a Vannessa Carey). These records are especially relevant because, according to Demangel [2], Liolemus Cristiani is presumed omnivorous; it has only been observed eating<br>shoots of plants, although the consumption of insects is likely. Thus, this record confirms the hypothesis that Liolemus Cristiani is omnivorous.<br>We took these records, near to Laguna de las Animas, in the first kilometer walking to the Termas del Azufre, at noon, on February 21, 2017. The exact point is around coordinates 35.484052, -70.837544 (see red mark in the attached map). As is depicted by the map, there is a small water stream from the point we take the records to Laguna las Animas. In the edges of the stream, plants and insects grow; as it is now confirmed, they serve as the Liolaemus Cristiani food.<br><br>According to Demangel [2], there are records of the Liolaemus Cristiani in the Laguna de las Animas. However, to the best of our knowledge, there is no much information about its occurrences in the streams flowing into the lagoon. We can also observe other flows in the map; we presume that Liolaemus Cristiani also lives in there. An open question is if there are specimens of Liolaemus Cristiani, in additional water sources as Laguna Mondaca, around eight kilometers to the east of Laguna de las Animas; an thus, if Liolaemus Cristiani crosses to Argentina.<br><br><b>References</b><br><br>[1] H. Nuñez., J. Navarro, and J. Loyola. "Liolaemus maldonadae y Liolaemus cristiani, dos especies nuevas de lagartijas para Chile (Reptilia, Squamata)." Boletín del Museo Nacional de Historia Natural, Chile 42 (1991): 79-88.<br>[2] D. Demangel, "Guía de Campo Reptiles del centro sur de Chile." Corporación Chilena de la Madera (2016). Concepción, Chile 187 pp.
DOI: 10.6084/m9.figshare.7837694.v1
title: Liolaemus Cristiani eating a Vanessa Carye

description: Liolaemus Cristiani was described by Nuñez et al. [1] in 1991. It is endemic of the Andean Mountains, in the center area of Chile. There are records of it in the Región de O'Higgins and the Región del Maule, between the 2,000 and 2,500 meters above sea level. In this archive item, we provide multimedia records of a specimen eating a butterfly (a Vannessa Carey). These records are especially relevant because, according to Demangel [2], Liolemus Cristiani is presumed omnivorous; it has only been observed eating<br>shoots of plants, although the consumption of insects is likely. Thus, this record confirms the hypothesis that Liolemus Cristiani is omnivorous.<br>We took these records, near to Laguna de las Animas, in the first kilometer walking to the Termas del Azufre, at noon, on February 21, 2017. The exact point is around coordinates 35.484052, -70.837544 (see red mark in the attached map). As is depicted by the map, there is a small water stream from the point we take the records to Laguna las Animas. In the edges of the stream, plants and insects grow; as it is now confirmed, they serve as the Liolaemus Cristiani food.<br><br>According to Demangel [2], there are records of the Liolaemus Cristiani in the Laguna de las Animas. However, to the best of our knowledge, there is no much information about its occurrences in the streams flowing into the lagoon. We can also observe other flows in the map; we presume that Liolaemus Cristiani also lives in there. An open question is if there are specimens of Liolaemus Cristiani, in additional water sources as Laguna Mondaca, around eight kilometers to the east of Laguna de las Animas; an thus, if Liolaemus Cristiani crosses to Argentina.<br><br><b>References</b><br><br>[1] H. Nuñez., J. Navarro, and J. Loyola. "Liolaemus maldonadae y Liolaemus cristiani, dos especies nuevas de lagartijas para Chile (Reptilia, Squamata)." Boletín del Museo Nacional de Historia Natural, Chile 42 (1991): 79-88.<br>[2] D. Demangel, "Guía de Campo Reptiles del centro sur de Chile." Corporación Chilena de la Madera (2016). Concepción, Chile 187 pp.
DOI: 10.6084/m9.figshare.7837796.v2
title: VAMS combine with molex-Flu to measure the influenza virus specific antibodies

description: Recently, volumetric absorptive microsampling (VAMS) has been used for peripheral blood sampling and analyses in several fields. VAMS ensures accurate sampling by collecting a fixed blood volume (10 or 20 $\mu$L) on a volumetric swab in blood spot format, and allows for long-term sample storage. The mPlex-Flu assay is a novel, multidimensional assay that measures the concentration of antibodies against multiple influenza virus simultaneously strains with a small volume of serum (less than 5 $\mu$L). Here we describe combining these two methods to measure multidimensional influenza antibody activity using a finger-stick and VAMS. In this study, we compared influenza antibody profiles measured from capillary blood obtained with a finger-stick, and venous whole blood collected by traditional phlebotomy from 20 subjects using the mPlex-Flu assay. We found that results with the two sampling methods were virtually identical across all influenza strains within the same subject (mean of $R^2$ =0.9470), and that antibodies remained stable over three weeks when VAMS samples were stored at room temperature and transported using a variety of shipping methods. Additionally, VAMS sampling is an easy and highly reproducible process; when volunteers performed finger stick VAMS at home by themselves, the comparison results of anti-HA antibody concentrations showed that they are highly consistent with sampling performed by study personnel on-site ($R^2$ =0.9496). This novel approach provides advantages for clinical influenza vaccine studies, including ease of sampling, low cost, and high accuracy. We conclude that these methods could provide an accurate and low-cost means for monitoring the influenza virus antibody responses in large population studies.
DOI: 10.6084/m9.figshare.7837796.v4
title: VAMS combine with molex-Flu to measure the influenza virus specific antibodies

description: Recently, volumetric absorptive microsampling (VAMS) has been used for peripheral blood sampling and analyses in several fields. VAMS ensures accurate sampling by collecting a fixed blood volume (10 or 20 $\mu$L) on a volumetric swab in blood spot format, and allows for long-term sample storage. The mPlex-Flu assay is a novel, multidimensional assay that measures the concentration of antibodies against multiple influenza virus simultaneously strains with a small volume of serum (less than 5 $\mu$L). Here we describe combining these two methods to measure multidimensional influenza antibody activity using a finger-stick and VAMS. In this study, we compared influenza antibody profiles measured from capillary blood obtained with a finger-stick, and venous whole blood collected by traditional phlebotomy from 20 subjects using the mPlex-Flu assay. We found that results with the two sampling methods were virtually identical across all influenza strains within the same subject (mean of $R^2$ =0.9470), and that antibodies remained stable over three weeks when VAMS samples were stored at room temperature and transported using a variety of shipping methods. Additionally, VAMS sampling is an easy and highly reproducible process; when volunteers performed finger stick VAMS at home by themselves, the comparison results of anti-HA antibody concentrations showed that they are highly consistent with sampling performed by study personnel on-site ($R^2$ =0.9496). This novel approach provides advantages for clinical influenza vaccine studies, including ease of sampling, low cost, and high accuracy. We conclude that these methods could provide an accurate and low-cost means for monitoring the influenza virus antibody responses in large population studies.
DOI: 10.25375/uct.7837673.v1
title: The role of selection in shaping the cranio-mandibular morphology of Paranthropus

description: This dataset contains 95th percentile values from frequency distributions of Mahalanobis’ distances (D2) calculated from extant hominoid models for each analysis used in the study. These values are used to evaluate the significance of the D2 values between fossil specimens. If D2 values are greater than the values presented in this table, then it is classified as statistically significant. Bolded red values indicate distances that are statistically significant compared to all of the 95% values from frequency distributions of Mahalanobis' distances calculated between extant hominoid models. Non-bolded red values indicate distances that are significant for at least one model.
DOI: 10.6084/m9.figshare.7837625
title: Model Outputs Obradors-Prats et al (2019).xlsx

description: Output of simulations from Obradors-Prats et al., (2019): A diagenesis model for geomechanical simulations: formulation and implications for pore pressure and development of geological structures