cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.2067402.v1
title: Revisiting doxycycline in pregnancy and early childhood – time to rebuild its reputation?

description: <b><i>Introduction:</i></b> Doxycycline is highly effective, inexpensive with a broad therapeutic spectrum and exceptional bioavailability. However these benefits have been overshadowed by its classification alongside the tetracyclines – class D drugs, contraindicated in pregnancy and in children under 8 years of age. Doxycycline-treatable diseases are emerging as leading causes of undifferentiated febrile illness in Southeast Asia. For example scrub typhus and murine typhus have an unusually severe impact on pregnancy outcomes, and current mortality rates for scrub typhus reach 12-13% in India and Thailand. The emerging evidence for these important doxycycline-treatable diseases prompted us to revisit doxycycline usage in pregnancy and childhood. <b><i>Areas Covered:</i></b> A systematic review of the available literature on doxycycline use in pregnant women and children revealed a safety profile of doxycycline that differed significantly from that of tetracycline; no correlation between the use of doxycycline and teratogenic effects during pregnancy or dental staining in children was found. <b><i>Expert Opinion:</i></b> The change of the US FDA pregnancy classification scheme to an evidence-based approach will enable adequate evaluation of doxycycline in common tropical illnesses and in vulnerable populations in clinical treatment trials, dosage-optimization pharmacokinetic studies and for the empirical treatment of undifferentiated febrile illnesses, especially in pregnant women and children.
DOI: 10.6084/m9.figshare.2067363
title: Cuestionario alumnos 15-16

description: Cuestionarios a los alumnos de la asignatura "Tecnología digital II" para conocer la opinión sobre el desarrollo de la misma.
DOI: 10.6084/m9.figshare.2067360
title: elf3_pif4_project_data_code

description: data and code pertinent to submitted manuscript.
DOI: 10.6084/m9.figshare.2067387.v1
title: “Glycosidic exclusion” does not include the Oh or Bombay Type

description: The molecular biological relationship between human fertility and the ABO(H) blood group phenotype formation becomes visible through special cell surface structures and immunoglobulin M specificities arising in people with the rare Oh or <i>Bombay</i> blood type, whom Charles Darwin would, by the history of his own family, the “<i>Darwin/Wedgewood Dynasty”</i>, have analyzed to result from reduced fertility in consanguinities. The classical type is characterized by the lack of expression of any ABO(H) epitope and instead shows the development of high isoagglutinin levels, additionally exerting strong binding of complement to anti-H agglutinin. The red cell surface presents with the naked structure Gal-β1-R, which has not been completed for the H-receptor (Fuc-α1-2-Gal-β1-R), thereby representing the structural fundament for ABOH epitopes. In its native form, the <i>Bombay</i> type occurs in individuals with the extremely rare genotype (h/h;se/se). This molecular biological phenomenon is explained by point mutations at the H- and Se genes on chromosome 19 such that the fucosyltransferases FUT1 and FUT2 are not encoded. FUT1 and FUT2 are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and fucosyl residues provide the functional-structural basis of the formation of any ABOH phenotype on the cell surface or in secretions and plasma proteins. Moreover, through developmental varying of the positions of the fucosyl residues between the cell surfaces and the heavy chains of immunoglobulins, they appear to augment or reduce antibody-mediated cellular cytotoxicity. This involves the regulation of growth processes and control over physiological autoreactivity in embryonic stem cell to germ cell transformation, where the predominantly <i>O</i>-glycosylations become in <i>Bombay type</i> individuals consequently exposed to metabolic competition with multiple glycosidic sites of extremely glycan depleted immunoglobulins.
DOI: 10.6084/m9.figshare.2067363.v1
title: Cuestionario alumnos 15-16

description: Cuestionarios a los alumnos de la asignatura "Tecnología digital II" para conocer la opinión sobre el desarrollo de la misma.
DOI: 10.6084/m9.figshare.2067360.v1
title: elf3_pif4_project_data_code

description: data and code pertinent to submitted manuscript.
DOI: 10.6084/m9.figshare.2067387.v2
title: “Glycosidic exclusion” does not include the Oh or Bombay Type

description: The molecular biological relationship between human fertility and the ABO(H) blood group phenotype formation becomes visible through special cell surface structures and immunoglobulin M specificities arising in people with the rare Oh or <i>Bombay</i> blood type, whom Charles Darwin would, by the history of his own family, the “<i>Darwin/Wedgewood Dynasty”</i>, have analyzed to result from reduced fertility in consanguinities. The classical type is characterized by the lack of expression of any ABO(H) epitope and instead shows the development of high isoagglutinin levels, additionally exerting strong binding of complement to anti-H agglutinin. The red cell surface presents with the naked structure Gal-β1-R, which has not been completed for the H-receptor (Fuc-α1-2-Gal-β1-R), thereby representing the structural fundament for ABOH epitopes. In its native form, the <i>Bombay</i> type occurs in individuals with the extremely rare genotype (h/h;se/se). This molecular biological phenomenon is explained by point mutations at the H- and Se genes on chromosome 19 such that the fucosyltransferases FUT1 and FUT2 are not encoded. FUT1 and FUT2 are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and fucosyl residues provide the functional-structural basis of the formation of any ABOH phenotype on the cell surface or in secretions and plasma proteins. Moreover, through developmental varying of the positions of the fucosyl residues between the cell surfaces and the heavy chains of immunoglobulins, they appear to augment or reduce antibody-mediated cellular cytotoxicity. This involves the regulation of growth processes and control over physiological autoreactivity in embryonic stem cell to germ cell transformation, where the predominantly <i>O</i>-glycosylations become in <i>Bombay type</i> individuals consequently exposed to metabolic competition with multiple glycosidic sites of extremely glycan depleted immunoglobulins.
DOI: 10.6084/m9.figshare.2067387.v3
title: “Glycosidic exclusion” does not include the "Oh" or Bombay Type

description: The classical <i>Bombay type</i> is characterized by the lack of expression of any ABO(H) epitope and instead shows the development of high isoagglutinin levels, additionally exerting strong binding of complement to anti-H agglutinin. The red cell surface presents with the naked structure Gal-β1-R, which has not been completed for the H-receptor (Fuc-α1-2-Gal-β1-R), thereby representing the structural fundament for ABOH epitopes. In its native form, the <i>Bombay</i> type occurs in individuals with the extremely rare genotype (h/h;se/se). This molecular biological phenomenon is explained by point mutations at the H- and Se genes on chromosome 19 such that the fucosyltransferases FUT1 and FUT2 are not encoded. FUT1 and FUT2 are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and fucosyl residues provide the functional-structural basis of the formation of any ABOH phenotype on the cell surface or in secretions and plasma proteins. Moreover, through developmental varying of the positions of the fucosyl residues between the cell surfaces and the heavy chains of immunoglobulins, they appear to augment or reduce antibody-mediated cellular cytotoxicity. This involves the regulation of growth processes and control over physiological autoreactivity in embryonic stem cell to germ cell transformation, where the predominantly <i>O</i>-glycosylations become in <i>Bombay type</i> individuals consequently exposed to metabolic competition with multiple glycosidic sites of extremely glycan depleted immunoglobulins.
DOI: 10.6084/m9.figshare.2067267
title: Predictors of cardiac morbidity in diabetic, new-onset diabetic and non-diabetic high-risk hypertensive patients: The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial

description: Diabetic and new-onset diabetic patients with hypertension have higher cardiac morbidity than patients without diabetes. We aimed to investigate whether baseline predictors of cardiac morbidity, the major constituent of the primary endpoint in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial, were different in patients with diabetes and new-onset diabetes compared to patients without diabetes. In total, 15,245 high-risk hypertensive patients in the VALUE trial were followed for an average of 4.2 years. At baseline, 5250 patients were diabetic by the 1999 World Health Organization criteria, 1298 patients developed new-onset diabetes and 8697 patients stayed non-diabetic during follow-up. Cardiac morbidity was defined as a composite of myocardial infarction and heart failure requiring hospitalization, and baseline predictors were identified by univariate and multivariate stepwise Cox regression analyses. History of coronary heart disease (CHD) and age were the most important predictors of cardiac morbidity in both diabetic and non-diabetic patients. History of CHD, history of stroke and age were the only significant predictors of cardiac morbidity in patients with new-onset diabetes. Predictors of cardiac morbidity, in particular history of CHD and age, were essentially the same in high-risk hypertensive patients with diabetes, new-onset diabetes and without diabetes who participated in the VALUE trial.
DOI: 10.6084/m9.figshare.2067267.v1
title: Predictors of cardiac morbidity in diabetic, new-onset diabetic and non-diabetic high-risk hypertensive patients: The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial

description: Diabetic and new-onset diabetic patients with hypertension have higher cardiac morbidity than patients without diabetes. We aimed to investigate whether baseline predictors of cardiac morbidity, the major constituent of the primary endpoint in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial, were different in patients with diabetes and new-onset diabetes compared to patients without diabetes. In total, 15,245 high-risk hypertensive patients in the VALUE trial were followed for an average of 4.2 years. At baseline, 5250 patients were diabetic by the 1999 World Health Organization criteria, 1298 patients developed new-onset diabetes and 8697 patients stayed non-diabetic during follow-up. Cardiac morbidity was defined as a composite of myocardial infarction and heart failure requiring hospitalization, and baseline predictors were identified by univariate and multivariate stepwise Cox regression analyses. History of coronary heart disease (CHD) and age were the most important predictors of cardiac morbidity in both diabetic and non-diabetic patients. History of CHD, history of stroke and age were the only significant predictors of cardiac morbidity in patients with new-onset diabetes. Predictors of cardiac morbidity, in particular history of CHD and age, were essentially the same in high-risk hypertensive patients with diabetes, new-onset diabetes and without diabetes who participated in the VALUE trial.
DOI: 10.6084/m9.figshare.2067249
title: A multi FASTA alignment of Salmonella Typhi genomes, mapped to CT18 from the Nature genetics paper - Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

description: A multi FASTA alignment of Salmonella Typhi genomes, mapped to CT18 ( AL513382) with repeat regions and mobile elements filtered out. It is an intermediate result from the Nature Genetics paper "Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events" by Vanessa Wong. This dataset is used as part of another paper on the SNP-sites software.
DOI: 10.6084/m9.figshare.2067264
title: Chimp1 reference and simulated long/short reads

description: Files for long vs short de-novo assembly tutorial.
DOI: 10.6084/m9.figshare.2067264.v1
title: Chimp1 reference and simulated long/short reads

description: Files for long vs short de-novo assembly tutorial.
DOI: 10.6084/m9.figshare.2067387.v4
title: „Glycosidic exclusion“ does not include the „Oh“ or Bombay Type

description: The classical <i>Bombay type</i> is characterized by the lack of expression of any ABO(H) epitope and instead shows the development of high isoagglutinin levels, additionally exerting strong binding of complement to anti-H agglutinin. The red cell surface presents with the naked structure Gal-β1-R, which has not been completed for the H-receptor (Fuc-α1-2-Gal-β1-R), thereby representing the structural fundament for ABOH epitopes. In its native form, the <i>Bombay</i> type occurs in individuals with the extremely rare genotype (h/h;se/se). This molecular biological phenomenon is explained by point mutations at the H- and Se genes on chromosome 19 such that the fucosyltransferases FUT1 and FUT2 are not encoded. FUT1 and FUT2 are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and fucosyl residues provide the functional-structural basis of the formation of any ABOH phenotype on the cell surface or in secretions and plasma proteins. Moreover, through developmental varying of the positions of the fucosyl residues between the cell surfaces and the heavy chains of immunoglobulins, they appear to augment or reduce antibody-mediated cellular cytotoxicity. This involves the regulation of growth processes and control over physiological autoreactivity in embryonic stem cell to germ cell transformation, where the predominantly <i>O</i>-glycosylations become in <i>Bombay type</i> individuals consequently exposed to metabolic competition with multiple glycosidic sites of extremely glycan depleted immunoglobulins.
DOI: 10.6084/m9.figshare.2067183
title: Tag Recommendation Datasets

description: Associative Tag Recommendation Exploiting Multiple Textual FeaturesFabiano Belem, Eder Martins, Jussara M. Almeida Marcos Goncalves <br>In Proceedings of the 34th international ACM SIGIR conference on Research and development in Information Retrieval, July. 2011AbstractThis work addresses the task of recommending relevant tags to a target object by jointly exploiting three dimen- sions of the problem: (i) term co-occurrence with tags preassigned to the target object, (ii) terms extracted from mul- tiple textual features, and (iii) several metrics of tag relevance. In particular, we propose several new heuristic meth- ods, which extend previous, highly effective and efficient, state-of-the-art strategies by including new metrics that try to capture how accurately a candidate term describes the object’s content. We also exploit two learning to rank techniques, namely RankSVM and Genetic Programming, for the task of generating ranking functions that combine multiple metrics to accurately estimate the relevance of a tag to a given object. We evaluate all proposed methods in various scenarios for three popular Web 2.0 applications, namely, LastFM, YouTube and YahooVideo. We found that our new heuristics greatly outperform the methods on which they are based, producing gains in precision of up to 181%, as well as another state-of-the-art technique, with improvements in precision of up to 40% over the best baseline in any scenario. Some further improvements can also be achieved, in some scenarios, with the new learning-to-rank based strategies, which have the additional advantage of being quite flexible and easily extensible to exploit other aspects of the tag recommendation problem.<br>Bibtex Citation<pre>@inproceedings{belem@sigir11, author = {Fabiano Bel\'em and Eder Martins and Jussara Almeida and Marcos Gon\c{c}alves}, title = {Associative Tag Recommendation Exploiting Multiple Textual Features}, booktitle = {{Proceedings of the 34th international ACM SIGIR conference on Research and development in Information Retrieval (SIGIR'11)}}, month = {{July}}, year = {2011} }</pre>
DOI: 10.6084/m9.figshare.2067387.v5
title: „Glycosidic exclusion“ does not include the „Oh“ or Bombay Type

description: The classical <i>Bombay type</i> is characterized by the lack of expression of any ABO(H) epitope and instead shows the development of high isoagglutinin levels, additionally exerting strong binding of complement to anti-H agglutinin. The red cell surface presents with the naked structure Gal-β1-R, which has not been completed for the H-receptor (Fuc-α1-2-Gal-β1-R), thereby representing the structural fundament for ABOH epitopes. In its native form, the <i>Bombay</i> type occurs in individuals with the extremely rare genotype (h/h;se/se). This molecular biological phenomenon is explained by point mutations at the H- and Se genes on chromosome 19 such that the fucosyltransferases FUT1 and FUT2 are not encoded. FUT1 and FUT2 are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and fucosyl residues provide the functional-structural basis of the formation of any ABOH phenotype on the cell surface or in secretions and plasma proteins. Moreover, through developmental varying of the positions of the fucosyl residues between the cell surfaces and the heavy chains of immunoglobulins, they appear to augment or reduce antibody-mediated cellular cytotoxicity. This involves the regulation of growth processes and control over physiological autoreactivity in embryonic stem cell to germ cell transformation, where the predominantly <i>O</i>-glycosylations become in <i>Bombay type</i> individuals consequently exposed to metabolic competition with multiple glycosidic sites of extremely glycan depleted immunoglobulins.
DOI: 10.6084/m9.figshare.2067174
title: No evidence for surface organization in Kanizsa configurations during continuous flash suppression

description: This fileset contains all data reported in: <br>Moors, P., Wagemans, J., van Ee, R., de-Wit, L. (2015). No evidence for surface organization in Kanizsa configurations during continuous flash suppression. Attention, Perception, & Psychophyics. <br>The Explanation_Dataset file provides an explanation of all variables.
DOI: 10.6084/m9.figshare.2067174.v1
title: No evidence for surface organization in Kanizsa configurations during continuous flash suppression

description: This fileset contains all data reported in: <br>Moors, P., Wagemans, J., van Ee, R., de-Wit, L. (2015). No evidence for surface organization in Kanizsa configurations during continuous flash suppression. Attention, Perception, & Psychophyics. <br>The Explanation_Dataset file provides an explanation of all variables.
DOI: 10.6084/m9.figshare.2067387.v6
title: „Glycosidic exclusion“ not protecting the „Oh“ or Bombay Type

description: The classical <i>Bombay type</i> is characterized by the lack of expression of any ABO(H) epitope and instead shows the development of high isoagglutinin levels, additionally exerting strong binding of complement to anti-H agglutinin. The red cell surface presents with the naked structure Gal-β1-R, which has not been completed for the H-receptor (Fuc-α1-2-Gal-β1-R), thereby representing the structural fundament for ABOH epitopes. In its native form, the <i>Bombay</i> type occurs in individuals with the extremely rare genotype (h/h;se/se). This molecular biological phenomenon is explained by point mutations at the H- and Se genes on chromosome 19 such that the fucosyltransferases FUT1 and FUT2 are not encoded. FUT1 and FUT2 are epistatically connected with the A and B allelic glycotransferase functions encoded on chromosome 9, and fucosyl residues provide the functional-structural basis of the formation of any ABOH phenotype on the cell surface or in secretions and plasma proteins. Moreover, through developmental varying of the positions of the fucosyl residues between the cell surfaces and the heavy chains of immunoglobulins, they appear to augment or reduce antibody-mediated cellular cytotoxicity. This involves the regulation of growth processes and control over physiological autoreactivity in embryonic stem cell to germ cell transformation, where the predominantly <i>O</i>-glycosylations become in <i>Bombay type</i> individuals consequently exposed to metabolic competition with multiple glycosidic sites of extremely glycan-depleted immunoglobulins.
DOI: 10.6084/m9.figshare.2067183.v1
title: data.tar.gz

description: Associative Tag Recommendation Exploiting Multiple Textual FeaturesFabiano Belem, Eder Martins, Jussara M. Almeida Marcos Goncalves <br>In Proceedings of the 34th international ACM SIGIR conference on Research and development in Information Retrieval, July. 2011AbstractThis work addresses the task of recommending relevant tags to a target object by jointly exploiting three dimen- sions of the problem: (i) term co-occurrence with tags preassigned to the target object, (ii) terms extracted from mul- tiple textual features, and (iii) several metrics of tag relevance. In particular, we propose several new heuristic meth- ods, which extend previous, highly effective and efficient, state-of-the-art strategies by including new metrics that try to capture how accurately a candidate term describes the object’s content. We also exploit two learning to rank techniques, namely RankSVM and Genetic Programming, for the task of generating ranking functions that combine multiple metrics to accurately estimate the relevance of a tag to a given object. We evaluate all proposed methods in various scenarios for three popular Web 2.0 applications, namely, LastFM, YouTube and YahooVideo. We found that our new heuristics greatly outperform the methods on which they are based, producing gains in precision of up to 181%, as well as another state-of-the-art technique, with improvements in precision of up to 40% over the best baseline in any scenario. Some further improvements can also be achieved, in some scenarios, with the new learning-to-rank based strategies, which have the additional advantage of being quite flexible and easily extensible to exploit other aspects of the tag recommendation problem.<br>Bibtex Citation<pre>@inproceedings{belem@sigir11, author = {Fabiano Bel\'em and Eder Martins and Jussara Almeida and Marcos Gon\c{c}alves}, title = {Associative Tag Recommendation Exploiting Multiple Textual Features}, booktitle = {{Proceedings of the 34th international ACM SIGIR conference on Research and development in Information Retrieval (SIGIR'11)}}, month = {{July}}, year = {2011} }</pre>
DOI: 10.6084/m9.figshare.2067156
title: Frocos2016's paper, modal specifications verification experimental results and data-sets

description: Frocos 2016<br>Modal specifications verification, data-sets and results