cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6124634
title: Bioethical dilemmas in the medical care of pregnant teenagers

description: Abstract The aim of this study is to identify and to discuss some bioethical aspects involved in medical assistance to pregnant teenagers. Through Integrative Review, it was selected two articles tackling the same chosen theme, contained in the Biblioteca Virtual em Saúde (Virtual Health Library) and published between 2010 and 2015. Based on researches, there was a significant decrease in the number of births among adolescents in the last five years. However, the indices are still worrying. As a result, it was found two alternatives in the relationship between doctor and pregnant teenagers: medical ethics and induced abortion, it having the autonomy and not-malfeasance as bioethical dilemmas. The Bioethics provides systematic reflections in the sense of involving the professionals of health and education in sexual and reproductive health and providing assistance tothe young woman, in which preventive measures of an unwanted pregnancy avoid the Incidence of unsafe abortion and, consequently, avoid them to look for clandestine services.
DOI: 10.6084/m9.figshare.7507334
title: GEOGRAPHISMS AND POPULAR CULTURE

description: ABSTRACT The peripheries of cities and their inhabitants are represented by stigmas which are (re)produced as marks of an immutable stereotype, through derogatory values that blame them for the maladies of the city. However, it is important to investigate whether the culture of these populations is made up solely by poverty and violence as this single discourse about such communities would have us believe, in a type of geographical prejudice, geographism. From this point of view, this article examines the perspectives of the Rubem Berta neighborhood in Porto Alegre. This work uses the approach of Cultural and Humanistic Geography to investigate the concepts of geographism, speech, identity, place and landscape through local and non-local reports to comprehend the different meanings which social actors attribute to the place, by means of the Discourse Analysis method. The reports helped to recognize that in many cases topophilic experiences coexist with topophobic ones. This study allows an understanding of the Housing Estate not only as expressed by the single discourse, but rather as a locus of pluralities, cultural experiences, thoughts, ideas and ideals, evidencing heterogeneity in terms of place and landscape.
DOI: 10.6084/m9.figshare.7507334.v1
title: GEOGRAPHISMS AND POPULAR CULTURE

description: ABSTRACT The peripheries of cities and their inhabitants are represented by stigmas which are (re)produced as marks of an immutable stereotype, through derogatory values that blame them for the maladies of the city. However, it is important to investigate whether the culture of these populations is made up solely by poverty and violence as this single discourse about such communities would have us believe, in a type of geographical prejudice, geographism. From this point of view, this article examines the perspectives of the Rubem Berta neighborhood in Porto Alegre. This work uses the approach of Cultural and Humanistic Geography to investigate the concepts of geographism, speech, identity, place and landscape through local and non-local reports to comprehend the different meanings which social actors attribute to the place, by means of the Discourse Analysis method. The reports helped to recognize that in many cases topophilic experiences coexist with topophobic ones. This study allows an understanding of the Housing Estate not only as expressed by the single discourse, but rather as a locus of pluralities, cultural experiences, thoughts, ideas and ideals, evidencing heterogeneity in terms of place and landscape.
DOI: 10.6084/m9.figshare.7513643
title: Good Living (Sumak Kawsay): definitions, critique and implications for development planning in Ecuador

description: ABSTRACT While progressive governments are in transition in the region, in Ecuador the progressive government will continue. It is important to review some key aspects of the Ecuadorean context and its relation with the development model as a reflection of capital accumulation. This essay analyses Good Living/Sumak Kawsay as a civilization alternative and reviews National Development plans. Even though another way of living was proposed, little transformation was actually achieved; looking ten years back, we have a modern Ecuadorean state, a more humane capitalism. Despite Sumak Kawsay currently being empty of content, we suggest it is worthwhile to recover that dimension.
DOI: 10.6084/m9.figshare.7513643.v1
title: Good Living (Sumak Kawsay): definitions, critique and implications for development planning in Ecuador

description: ABSTRACT While progressive governments are in transition in the region, in Ecuador the progressive government will continue. It is important to review some key aspects of the Ecuadorean context and its relation with the development model as a reflection of capital accumulation. This essay analyses Good Living/Sumak Kawsay as a civilization alternative and reviews National Development plans. Even though another way of living was proposed, little transformation was actually achieved; looking ten years back, we have a modern Ecuadorean state, a more humane capitalism. Despite Sumak Kawsay currently being empty of content, we suggest it is worthwhile to recover that dimension.
DOI: 10.5281/zenodo.4630680
title: Data set related to the article "The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease"

description: This record contains row data related to the article "The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease". The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington's disease (HD), a neurodegenerative disorder caused by neural death due to expanded CAG repeats encoding a long polyglutamine tract in the huntingtin protein (Htt). Herein, we showed that striatal-derived cell lines with expanded Htt (STHdh Q<sup>111/111</sup>) expressed and secreted lower levels of BPIFB4, when compared with Htt expressing cells (STHdh Q<sup>7/7</sup>), which correlated with a defective stress response to proteasome inhibition. Overexpression of LAV-BPIFB4 in STHdh Q<sup>111/111</sup> cells was able to rescue both the BPIFB4 secretory profile and the proliferative/survival response. According to a well-established immunomodulatory role of LAV-BPIFB4, conditioned media from LAV-BPIFB4-overexpressing STHdh Q111<sup>/111</sup> cells were able to educate Immortalized Human Microglia-SV40 microglial cells. While STHdh Q<sup>111/111</sup> dying cells were ineffective to induce a CD163 + IL-10<sup>high</sup> pro-resolving microglia compared to normal STHdh Q<sup>7/7</sup>, LAV-BPIFB4 transduction promptly restored the central immune control through a mechanism involving the stromal cell-derived factor-1. In line with the in vitro results, adeno-associated viral-mediated administration of LAV-BPIFB4 exerted a CXCR4-dependent neuroprotective action in vivo in the R6/2 HD mouse model by preventing important hallmarks of the disease including motor dysfunction, body weight loss, and mutant huntingtin protein aggregation. In this view, LAV-BPIFB4, due to its pleiotropic ability in both immune compartment and cellular homeostasis, may represent a candidate for developing new treatment for HD.
DOI: 10.6084/m9.figshare.8031500.v1
title: Petrography and detrital zircon U-Pb geochronology of sedimentary rocks of the Campo Alegre Basin, Southern Brazil: implications for Gondwana assembly

description: Abstract The Campo Alegre Basin is a volcano-sedimentary sequence covering an area of about 500 km 2 , located at the northeast portion of Santa Catarina state (Brazil), and formed during the late stages of the Neoproterozoic era. Three main stratigraphic units compose this basin, the lowermost of which is the Bateias Formation, corresponding to the pre-volcanic stage. It is characterized by the fanglomeratic sediments at the basin’s northern boundary, which were deposited in a fluvial environment and progressively replaced by fluvial sandstones towards the south. Poorly sorted conglomerates and breccias compound the fanglomeratic facies, which comprises angular to subrounded fragments in a matrix ranging from sand fractions to fragments larger than gravel. The ubiquitous presence of volcanogenic and metamorphic fragments in the fanglomeratic facies strongly suggests that the Piên Magmatic Arc and a volcanic manifestation coeval with the earlier stages of the basin formation were important source areas, as well as the basin basement (the Luís Alves Terrane). In this sense, geological, petrographic, and detrital zircon geochronology data are combined in order to interpret the mechanisms that had acted during the deposition of these sedimentary rocks and to constraint the maximum depositional ages of Bateias Formation at ca. ~606 Ma.
DOI: 10.6084/m9.figshare.8031500
title: Petrography and detrital zircon U-Pb geochronology of sedimentary rocks of the Campo Alegre Basin, Southern Brazil: implications for Gondwana assembly

description: Abstract The Campo Alegre Basin is a volcano-sedimentary sequence covering an area of about 500 km 2 , located at the northeast portion of Santa Catarina state (Brazil), and formed during the late stages of the Neoproterozoic era. Three main stratigraphic units compose this basin, the lowermost of which is the Bateias Formation, corresponding to the pre-volcanic stage. It is characterized by the fanglomeratic sediments at the basin’s northern boundary, which were deposited in a fluvial environment and progressively replaced by fluvial sandstones towards the south. Poorly sorted conglomerates and breccias compound the fanglomeratic facies, which comprises angular to subrounded fragments in a matrix ranging from sand fractions to fragments larger than gravel. The ubiquitous presence of volcanogenic and metamorphic fragments in the fanglomeratic facies strongly suggests that the Piên Magmatic Arc and a volcanic manifestation coeval with the earlier stages of the basin formation were important source areas, as well as the basin basement (the Luís Alves Terrane). In this sense, geological, petrographic, and detrital zircon geochronology data are combined in order to interpret the mechanisms that had acted during the deposition of these sedimentary rocks and to constraint the maximum depositional ages of Bateias Formation at ca. ~606 Ma.
DOI: 10.6084/m9.figshare.14270314.v1
title: The reform of Primary Health Care and the use of outpatient services in the municipality of Rio de Janeiro (RJ), Brazil

description: ABSTRACT The municipality of Rio de Janeiro accomplished, from 2009, a reform of the health sector, focusing on Primary Health Care (PHC). This article aims to analyze the capacity of government of the municipality of Rio de Janeiro on common outpatient procedures and its retention in establishments guided by PHC, considering the use of outpatient services at the end of the first administrative reform cycle. The data suggest unintended effects of the policy, where the emphasis on the universalization of PHC strengthened the role of the municipality in outpatient care and, therefore, in the specialization of federal functions towards the precepts of the Brazilian Health Reform.
DOI: 10.6084/m9.figshare.14270314
title: The reform of Primary Health Care and the use of outpatient services in the municipality of Rio de Janeiro (RJ), Brazil

description: ABSTRACT The municipality of Rio de Janeiro accomplished, from 2009, a reform of the health sector, focusing on Primary Health Care (PHC). This article aims to analyze the capacity of government of the municipality of Rio de Janeiro on common outpatient procedures and its retention in establishments guided by PHC, considering the use of outpatient services at the end of the first administrative reform cycle. The data suggest unintended effects of the policy, where the emphasis on the universalization of PHC strengthened the role of the municipality in outpatient care and, therefore, in the specialization of federal functions towards the precepts of the Brazilian Health Reform.
DOI: 10.6084/m9.figshare.7517681
title: The challenges of integrated urban planning and management in Brazil: analysis of the Ministry of Cities experience

description: Abstract A sectoral logic has structured the actions of the Brazilian state and its inability to promote fair and balanced urban development is well known. As a result of maturity and social pressure, the Ministry of Cities was created to fulfill a gap regarding urban problems, partly solved by the development of the City Statute. Together, the Statute and the Ministry of Cities represent the first democratic Brazilian experience of urban land management, whereas the Ministry represents an intersectoral institutional effort never before conducted in the country. Although it has been 12 years since its creation, and despite numerous studies on its main funding programs, little is known regarding the intersectoral experience among their secretariats, how it builds bridges with other ministries and about its operations before local, regional and federative entities. Thus, using research methodology based on documentary analysis and interviews, this article seeks to identify the major advances in Urban Planning and Management deriving from the creation of the Ministry of Cities as well as to contribute to the understanding of its impact on the federal balance. Despite finding considerable advances in sectoral integration, the study found gaps in the articulation of the state scale with the others, as well as low participation of the state entity in the funding made available by the Ministry of Cities.
DOI: 10.6084/m9.figshare.7517681.v1
title: The challenges of integrated urban planning and management in Brazil: analysis of the Ministry of Cities experience

description: Abstract A sectoral logic has structured the actions of the Brazilian state and its inability to promote fair and balanced urban development is well known. As a result of maturity and social pressure, the Ministry of Cities was created to fulfill a gap regarding urban problems, partly solved by the development of the City Statute. Together, the Statute and the Ministry of Cities represent the first democratic Brazilian experience of urban land management, whereas the Ministry represents an intersectoral institutional effort never before conducted in the country. Although it has been 12 years since its creation, and despite numerous studies on its main funding programs, little is known regarding the intersectoral experience among their secretariats, how it builds bridges with other ministries and about its operations before local, regional and federative entities. Thus, using research methodology based on documentary analysis and interviews, this article seeks to identify the major advances in Urban Planning and Management deriving from the creation of the Ministry of Cities as well as to contribute to the understanding of its impact on the federal balance. Despite finding considerable advances in sectoral integration, the study found gaps in the articulation of the state scale with the others, as well as low participation of the state entity in the funding made available by the Ministry of Cities.
DOI: 10.6084/m9.figshare.6318599
title: The Timed Up and Go as a screening tool for fragility in physically active elderly

description: Abstract Objective This study aimed to evaluate the performance of the Timed Up and Go (TUG) as a screening tool for fragility in physically active elderly. Method This is a cross-sectional study with a Receiver Operating Characteristic (ROC) curve to evaluate the diagnostic adequacy of the test. Results The TUG showed adequate sensitivity (90.0%), specificity (35.5%), PPV (32.6%) and VPN (90.9%) for predicting fragility. The suggested cutoff point was TUG ≥7.21 seconds. Conclusion In addition to the easy applicability and low cost, the TUG is important for tracking and early identifying individuals with likely fragility, enabling planning interventions, preventing functional decline. Keywords: ROC curve; frail elderly; exercise.
DOI: 10.6084/m9.figshare.6318599.v1
title: The Timed Up and Go as a screening tool for fragility in physically active elderly

description: Abstract Objective This study aimed to evaluate the performance of the Timed Up and Go (TUG) as a screening tool for fragility in physically active elderly. Method This is a cross-sectional study with a Receiver Operating Characteristic (ROC) curve to evaluate the diagnostic adequacy of the test. Results The TUG showed adequate sensitivity (90.0%), specificity (35.5%), PPV (32.6%) and VPN (90.9%) for predicting fragility. The suggested cutoff point was TUG ≥7.21 seconds. Conclusion In addition to the easy applicability and low cost, the TUG is important for tracking and early identifying individuals with likely fragility, enabling planning interventions, preventing functional decline. Keywords: ROC curve; frail elderly; exercise.
DOI: 10.5281/zenodo.4630775
title: Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations

description: Dataset of the original data presented in the "Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag<sub>2</sub>S Nanothermometers and In Silico Simulations" paper published on Advanced Science.<br> <br> Abstract: Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag<sub>2</sub>S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag<sub>2</sub>S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.
DOI: 10.6084/m9.figshare.7518176
title: Planning and dissemination of research as a parameter of integrity in animal research

description: Abstract Integrity in animal research, coupled with scientific and social responsibility, demands rigor in the construction and execution of the protocol, commitment to the promotion of animal welfare and the dissemination of suitable data. Protocols for submitting projects to the Ethics Committee on Animal Use, editorial policies and dissemination of the methodology as tools to promote research integrity were analysed based on the questioning of the vulnerability of researchers not trained to fulfill this demand. The results supported the insertion of planning and dissemination of research as a parameter of integrity and adherence to the principle of 3R (Replacement, Reduction and Refinement) as a guide to the decision of how much and how and why to use animals in research. We verified the efficiency of the administrative and legal instrument as a promoter of reflection on technical, ethical, social and legal conception and society. These should be subsidized by the educational role of Bioethics, carried out by committees to mitigate vulnerabilities of the researcher.
DOI: 10.6084/m9.figshare.7518176.v1
title: Planning and dissemination of research as a parameter of integrity in animal research

description: Abstract Integrity in animal research, coupled with scientific and social responsibility, demands rigor in the construction and execution of the protocol, commitment to the promotion of animal welfare and the dissemination of suitable data. Protocols for submitting projects to the Ethics Committee on Animal Use, editorial policies and dissemination of the methodology as tools to promote research integrity were analysed based on the questioning of the vulnerability of researchers not trained to fulfill this demand. The results supported the insertion of planning and dissemination of research as a parameter of integrity and adherence to the principle of 3R (Replacement, Reduction and Refinement) as a guide to the decision of how much and how and why to use animals in research. We verified the efficiency of the administrative and legal instrument as a promoter of reflection on technical, ethical, social and legal conception and society. These should be subsidized by the educational role of Bioethics, carried out by committees to mitigate vulnerabilities of the researcher.
DOI: 10.6084/m9.figshare.9871586
title: Institutional aspects for the adoption of Interprofessional Education in nursing and medical training

description: ABSTRACT The theoretical-conceptual and methodological frameworks of Interprofessional Education in Health (IPE) have been widely recognized throughout the world as useful for the development of collaborative competences for effective teamwork. This article aims to explore the perceptions of nursing and medical students regarding the institutional factors that interfere in the adoption of IPE initiatives in their training contexts. It is a case study, which adopted the qualitative approach and the exploratory perspective. The research participants were nursing and medical students from two public universities from a Brazilian Northeastern state - one state and one federal. The focus group was chosen for data collection, and the categorical content analysis technique was used, observing the phases of pre-analysis, material exploration and treatment of results. Three thematic categories were built a posteriori: the importance of teamwork, the institutional contexts for the adoption of the IPE and challenges for the adoption of the IPE. Although the realities researched present advances in curricular changes, such as the approximation of teaching with the reality of services, the adoption of more active methods for the formation of critical and reflexive subjects, the gaps in the development of collaborative competences are still notorious.