cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21997616
title: Cystic Fibrosis Transmembrane Conductance Regulator Attenuates Oxidative Stress-Induced Injury in Diabetic Retinopathy Rats

description: To investigate the effects of cystic fibrosis transmembrane conductance regulator (CFTR) on oxidative stress-induced injury of diabetic retinopathy (DR) rats. DR rat model was constructed treated with Ad-CFTR. Hematoxylin and Eosin (HE) staining was applied for testing the thickness of each layer of retinal tissues. Enzyme-linked immunosorbent assay (ELISA) was used to determine levels of serum inflammatory cytokines and contents of oxidative stress related genes in rats. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) staining was used to detect retinal cell apoptosis, and western blotting to measure the expression of MAPK/NF-κB pathway-related proteins in retinal tissues. Our experiment revealed the remarkable decrease of CFTR protein in retinal tissues of DR rats. DR rats had decreased body weight and increased blood glucose level, with decreased thickness of total retinal thickness (TRT), outer nuclear layer and outer plexiform layer (ONL + OPL), inner nuclear layer (INL), and inner plexiform layer (IPL). Besides, DR rats were apparently up-regulated in the expression of pro-inflammatory cytokines, with increased malondial dehyde (MDA), p-ERK1/2/ERK1/2 and p-JNK1/2/JNK1/2 expressions, decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in retinal tissues, as well as up-regulated p65 protein in nucleus and down-regulated p65 protein in cytoplasm. DR rats treated with Ad-CFTR were effectively improved regarding the above parameters except body weight and blood glucose. CFTR can inhibit MAPK/NF-κB signaling pathway to ameliorate inflammatory response and oxidative stress-induced injury of DR rats, thereby reducing retinal cell apoptosis and playing a protective role in retina.
DOI: 10.48597/xkbc-9c55
title: Particle_number_size_distribution at Hohenpeissenberg

description: Measurement of Particle_number_size_distribution at Hohenpeissenberg
DOI: 10.48597/xrx2-qhtv
title: Particle_number_size_distribution at Hohenpeissenberg

description: Measurement of Particle_number_size_distribution at Hohenpeissenberg
DOI: 10.48597/xxr8-6ecj
title: Particle_number_size_distribution at Hohenpeissenberg

description: Measurement of Particle_number_size_distribution at Hohenpeissenberg
DOI: 10.48597/yv8p-kx5y
title: Particle_number_size_distribution at Hohenpeissenberg

description: Measurement of Particle_number_size_distribution at Hohenpeissenberg
DOI: 10.48597/yvqy-e3r6
title: Particle_number_size_distribution at Hohenpeissenberg

description: Measurement of Particle_number_size_distribution at Hohenpeissenberg
DOI: 10.48597/zz8h-zte8
title: Particle_number_size_distribution at Hohenpeissenberg

description: Measurement of Particle_number_size_distribution at Hohenpeissenberg
DOI: 10.48597/25v5-5xry
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/2h49-wsqz
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/2ktg-kjnh
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/3am7-qwbg
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/3m7f-hemf
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/4pf2-zmkq
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/55cp-np4a
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/695v-wy9c
title: Measurement of Ozone at Voss

description: Measurement of Ozone at Voss
DOI: 10.48597/6qm2-q5f6
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.6084/m9.figshare.21997616.v1
title: Cystic Fibrosis Transmembrane Conductance Regulator Attenuates Oxidative Stress-Induced Injury in Diabetic Retinopathy Rats

description: To investigate the effects of cystic fibrosis transmembrane conductance regulator (CFTR) on oxidative stress-induced injury of diabetic retinopathy (DR) rats. DR rat model was constructed treated with Ad-CFTR. Hematoxylin and Eosin (HE) staining was applied for testing the thickness of each layer of retinal tissues. Enzyme-linked immunosorbent assay (ELISA) was used to determine levels of serum inflammatory cytokines and contents of oxidative stress related genes in rats. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) staining was used to detect retinal cell apoptosis, and western blotting to measure the expression of MAPK/NF-κB pathway-related proteins in retinal tissues. Our experiment revealed the remarkable decrease of CFTR protein in retinal tissues of DR rats. DR rats had decreased body weight and increased blood glucose level, with decreased thickness of total retinal thickness (TRT), outer nuclear layer and outer plexiform layer (ONL + OPL), inner nuclear layer (INL), and inner plexiform layer (IPL). Besides, DR rats were apparently up-regulated in the expression of pro-inflammatory cytokines, with increased malondial dehyde (MDA), p-ERK1/2/ERK1/2 and p-JNK1/2/JNK1/2 expressions, decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in retinal tissues, as well as up-regulated p65 protein in nucleus and down-regulated p65 protein in cytoplasm. DR rats treated with Ad-CFTR were effectively improved regarding the above parameters except body weight and blood glucose. CFTR can inhibit MAPK/NF-κB signaling pathway to ameliorate inflammatory response and oxidative stress-induced injury of DR rats, thereby reducing retinal cell apoptosis and playing a protective role in retina.
DOI: 10.48597/6qwn-xc6w
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/6zvr-mbhy
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.6084/m9.figshare.20424779
title: Dysregulated MAPK signaling pathway in acute myeloid leukemia with RUNX1 mutations

description: Acute myeloid leukemia (AML) is a hematologic malignancy with genetic alterations. RUNX1, which is an essential transcription factor for hematopoiesis, is frequently mutated in AML. Loss-of-function mutation of RUNX1 is correlated with poor prognosis of AML patients. It is urgent to reveal the underlying mechanism. TCGA AML, GSE106291, GSE142700, and GSE67609 datasets were used. R package was used to define differentially expressed miRNAs, miRNA target genes, RUNX1-related gene, RUNX directly regulating genes, and so on. The relationship of gene expression with overall survival was analyzed by Cox regression. KEGG and GO analyses were applied to the above-mentioned genesets and overlapped genes. Alteration and importance of MAPK pathway were validated in K562 cells by Western blotting and apoptosis assay in vitro. RUNX1 regulated MAPK pathway indirectly and directly. MAPK pathway was altered in K562-cell-induced mutated RUNX1, and these cells were more sensitive to AraC after p38 was inhibited. RUNX1 could modulate MAPK pathway, which may provide a potential therapeutic target for AML patients with RUNX1 mutations.
DOI: 10.48597/743e-m4dq
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.6084/m9.figshare.20424779.v1
title: Dysregulated MAPK signaling pathway in acute myeloid leukemia with RUNX1 mutations

description: Acute myeloid leukemia (AML) is a hematologic malignancy with genetic alterations. RUNX1, which is an essential transcription factor for hematopoiesis, is frequently mutated in AML. Loss-of-function mutation of RUNX1 is correlated with poor prognosis of AML patients. It is urgent to reveal the underlying mechanism. TCGA AML, GSE106291, GSE142700, and GSE67609 datasets were used. R package was used to define differentially expressed miRNAs, miRNA target genes, RUNX1-related gene, RUNX directly regulating genes, and so on. The relationship of gene expression with overall survival was analyzed by Cox regression. KEGG and GO analyses were applied to the above-mentioned genesets and overlapped genes. Alteration and importance of MAPK pathway were validated in K562 cells by Western blotting and apoptosis assay in vitro. RUNX1 regulated MAPK pathway indirectly and directly. MAPK pathway was altered in K562-cell-induced mutated RUNX1, and these cells were more sensitive to AraC after p38 was inhibited. RUNX1 could modulate MAPK pathway, which may provide a potential therapeutic target for AML patients with RUNX1 mutations.
DOI: 10.48597/83hm-aatc
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/856x-r66k
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/87b3-vzf9
title: Measurement of Ozone at Voss

description: Measurement of Ozone at Voss
DOI: 10.48597/8zp3-dw82
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/9w5a-79q9
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/ahra-xxa4
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/ajss-7emq
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/bkzs-cd8r
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/bqc5-ckrn
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/c6za-nv9u
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/c7pu-skhs
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/ce6x-j3ca
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/cnr8-a79f
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/d6yy-yrj4
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/ddxj-yesr
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/dgr2-4dm6
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/dyn4-mxz9
title: Measurement of Ozone at Voss

description: Measurement of Ozone at Voss
DOI: 10.48597/ebzd-7fuj
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.6084/m9.figshare.12560495
title: Additional file 1 of Identification of four hub genes as promising biomarkers to evaluate the prognosis of ovarian cancer in silico

description: Additional file 1: Table S1. GO and KEGG pathway enrichment analysis (all terms with statistical difference).
DOI: 10.48597/f4ae-rmn5
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.6084/m9.figshare.12560495.v1
title: Additional file 1 of Identification of four hub genes as promising biomarkers to evaluate the prognosis of ovarian cancer in silico

description: Additional file 1: Table S1. GO and KEGG pathway enrichment analysis (all terms with statistical difference).
DOI: 10.48597/fjvp-fxtp
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/g498-72xj
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/g8vy-zwbk
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/gmpj-mbsm
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/h73n-fpag
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/h8xw-jzvv
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/h9c4-44sq
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/hnvd-kz3r
title: Measurement of Ozone at Voss

description: Measurement of Ozone at Voss
DOI: 10.48597/hxax-2bbc
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/j4hj-pdzf
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/j4zd-dkpe
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/j56s-cvuu
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/j6ym-zx5d
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/jhbe-mwh5
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/jqcf-ysqz
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/jrmt-69es
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/kbtx-27r5
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/krsw-mmr4
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.48597/kxgu-rbnc
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/kycy-qcdh
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/madw-jmqa
title: Measurement of Ozone at Voss

description: Measurement of Ozone at Voss
DOI: 10.48597/ntbd-wwsj
title: Measurement of Ozone at Klyve

description: Measurement of Ozone at Klyve
DOI: 10.48597/p29a-t9y3
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/p37k-vkab
title: Measurement of Ozone at Hurdal

description: Measurement of Ozone at Hurdal
DOI: 10.48597/p3xd-jg8t
title: Measurement of Ozone at Karasjok

description: Measurement of Ozone at Karasjok
DOI: 10.48597/p6ev-pqg4
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.5281/zenodo.10222922
title: Ambitious Efforts on Residual Emissions can Reduce CO2 Removal and Lower Peak Temperatures in a Net-Zero Future

description: Carbon dioxide removal (CDR) is expected to play a critical role in reaching net zero CO2 and especially net zero GHG emissions. However, the extent to which the role of CDR in counterbalancing residual emissions can be reduced has not yet been fully quantified. Here, we use a state-of-the-art integrated assessment model to develop a “Maximum Sectoral Effort” scenario which features global emissions policies alongside ambitious effort across sectors to reduce their gross GHG emissions and thereby the CDR required for offsets. We find that these efforts can reduce CDR by over 50% globally, increase both the relative and absolute role of the land sink in storing carbon, and more evenly distribute CDR contributions and associated side-effects across regions compared to CO2 pricing alone. Furthermore, the lower cumulative CO2 and nonCO2 emissions leads to earlier and lower peak temperatures. Emphasizing reductions in gross, in addition to net emissions while disallowing the substitution of less durable CDR for offsets can therefore reduce both physical and transition risks associated with high CDR deployment and temperature overshoot.
DOI: 10.48597/qdzt-uqa6
title: Measurement of Ozone at Voss

description: Measurement of Ozone at Voss
DOI: 10.48597/rgbn-dzwc
title: Measurement of Ozone at Langesund

description: Measurement of Ozone at Langesund
DOI: 10.6084/m9.figshare.19376329
title: Drug-induced Stevens-Johnson syndrome: a disproportionality analysis from the pharmacovigilance database of the World Health Organization

description: Stevens-Johnson syndrome is a rare but serious skin condition, which can lead to death. Stevens-Johnson syndrome is usually attributed to drug-induced reactions, thus making it vital for clinicians to prevent its occurrence by knowing the trigger drugs. The objective of this study was to comprehensively and systematically excavate the drugs that cause SJS to provide references for clinician. This is an observational, retrospective study, conducting a disproportionality analysis. Where the Information Component (IC) method and Reporting odds ratio (ROR) are used to mine the drugs that cause SJS. A total of 17,787,905 reports were extracted from VigiBase database, of which 25,051 reports were related to SJS. The 18–44 age group had the largest number of cases (N=7,973, 31.83%). A total of 295 drugs was detected as signals. Allopurinol (IC025/ROR025=5.86/69.84), phenytoin (IC025/ROR025=5.60/57.65) and carbamazepine (IC025/ROR025=5.25/43.88) were the top 3 strongest signals. Our study only considered the possibility of SJS caused by a single drug.         Allopurinol, phenytoin and carbamazepine were three strongest signals. Garenoxaci, carbocisteine and dimetindene were strong signals, but there are no relevant cases reported on PubMed or specific SJS in labels, which need further study to verify.
DOI: 10.5281/zenodo.10276838
title: Cervical whole slide images and annotations for automated reporting of cervical biopsies using artificial intelligence

description: The dataset comprises 2540 whole slide images of cervical cancer biopsies scanned using a Phillips Ultra Fast Scanner (UFS) with resolution equivalent to 40x or more specifically 0.25 microns/pixel, and stored in the isyntax file format. The dataset also contains detailed annotations for each slide specifying areas as malignant, high grade, low grade or normal/inflammation. Finally there is an index of slides, with the overall classification and sub -classifications for each slide and if they are part of training, validation or testing sets.
description: This study uses archived samples from the NHS Greater Glasgow and Clyde Biorepository and Pathology Tissue Resource. Patients gave informed consent for surplus tissue to be stored and used for medical research, this consent was recorded in an electronic Surplus Tissue Authorisation form. All data was de-identified within the biorepository and as provided is fully anonymized.

Ethics approval for the study was granted by NHS Greater Glasgow and Clyde Biorepository and Pathology Tissue Resource (REC reference 16/WS/0207) on 4th April 2019.
Biorepository approval was obtained (application number 511)
DOI: 10.5281/zenodo.10276837
title: Cervical whole slide images and annotations for automated reporting of cervical biopsies using artificial intelligence

description: The dataset comprises 2540 whole slide images of cervical cancer biopsies scanned using a Phillips Ultra Fast Scanner (UFS) with resolution equivalent to 40x or more specifically 0.25 microns/pixel, and stored in the isyntax file format. The dataset also contains detailed annotations for each slide specifying areas as malignant, high grade, low grade or normal/inflammation. Finally there is an index of slides, with the overall classification and sub -classifications for each slide and if they are part of training, validation or testing sets.
description: This study uses archived samples from the NHS Greater Glasgow and Clyde Biorepository and Pathology Tissue Resource. Patients gave informed consent for surplus tissue to be stored and used for medical research, this consent was recorded in an electronic Surplus Tissue Authorisation form. All data was de-identified within the biorepository and as provided is fully anonymized.

Ethics approval for the study was granted by NHS Greater Glasgow and Clyde Biorepository and Pathology Tissue Resource (REC reference 16/WS/0207) on 4th April 2019.
Biorepository approval was obtained (application number 511)
DOI: 10.6084/m9.figshare.20423696.v1
title: Additional file 1 of The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex

description: Additional file 1: Table S1. List of high-confidence proteins pulled down with ZFP57-AviTag in E14 ESCs and identified by nano-LC–MS/MS. Table S1b. List of shared proteins pulled down with streptavidin in E14 BirA (controls) and E14 BirA+ZFP57_Avitag (samples). Table S2a. MSH2 peaks identified by Bio-ChIP-seq in E14 ESCs. Replicate 1. Table S2b. MSH2 peaks identified by Bio-ChIP-seq in E14 ESCs. Replicate 2. Table S3. Coordinates of the imprinted gDMRs in mouse ESCs*. Table S4. Primer sequences.
DOI: 10.6084/m9.figshare.20423713
title: Additional file 2 of BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer

description: Additional file 2. Supplementary table 6
DOI: 10.6084/m9.figshare.20423713.v1
title: Additional file 2 of BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer

description: Additional file 2. Supplementary table 6
DOI: 10.6084/m9.figshare.12560606
title: Additional file 10 of Transcriptome profiling of venom gland from wasp species: de novo assembly, functional annotation, and discovery of molecular markers

description: Additional file 10 The GO enrichment of unigenes specific to the venom gland of V. velutina.
DOI: 10.6084/m9.figshare.12560606.v1
title: Additional file 10 of Transcriptome profiling of venom gland from wasp species: de novo assembly, functional annotation, and discovery of molecular markers

description: Additional file 10 The GO enrichment of unigenes specific to the venom gland of V. velutina.
DOI: 10.6084/m9.figshare.20424077
title: Additional file 1 of Involvement of MdWRKY40 in the defense of mycorrhizal apple against fusarium solani

description: Additional file 1: Supplementary Table S1. Sequencing data quality statistics.
DOI: 10.6084/m9.figshare.12560615
title: Additional file 11 of Transcriptome profiling of venom gland from wasp species: de novo assembly, functional annotation, and discovery of molecular markers

description: Additional file 11 The GO enrichment of unigenes specific to the venom gland of V. mandarinia smith.
DOI: 10.6084/m9.figshare.20423908
title: Additional file 5 of Discovery of cold-resistance genes in Vitis amurensis using bud-based quantitative trait locus mapping and RNA-seq

description: Additional file 5. The expression levels of 28 selected genes.
DOI: 10.6084/m9.figshare.20423908.v1
title: Additional file 5 of Discovery of cold-resistance genes in Vitis amurensis using bud-based quantitative trait locus mapping and RNA-seq

description: Additional file 5. The expression levels of 28 selected genes.
DOI: 10.15468/dl.is5qfw
title: Occurrence Download

description: A dataset containing 475 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Artemisia annua Pall."
 ]
}

 The dataset includes 475 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006813-171025204727650/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4zzwgz
title: Occurrence Download

description: A dataset containing 144 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Occurrence evidence, Living Specimen, Material sample, Human Observation, Machine Observation, Observation, Material citation)",
 "Country is United Kingdom of Great Britain and Northern Ireland",
 "OccurrenceStatus is Present",
 "TaxonKey is Alytes obstetricans (Laurenti, 1768)"
 ]
}

 The dataset includes 144 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019876-231002084531237/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.