cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.1594/pangaea.977459
title: Moisture and density (MAD) from IODP Hole 386-M0089A

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.1594/pangaea.977563
title: X-ray CT images of IODP Hole 386-M0083D

description: Collection of X-ray Computed Tomography (CT) images from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). The offshore phase of this expedition took place between 2021-04-13 and 2021-06-01 onboard Japanese R/V Kaimei from and to Yokosuka, Japan. This was followed by an onshore phase onboard D/V Chikyu between 2022-02-14 – 2022-03-15. X-ray CT scanning was performed on whole-round sections on board D/V Chikyu in July 2021, after the offshore phase and prior to the onshore phase, using a Discovery CT 750HD (GE Medical Systems) that produces 32 0.625 mm thick slice images every 0.4 s. Data generated for each core consist of core-axis-normal planes of X-ray attenuation values that are 512 × 512 pixels in size. Data were stored on the server as DICOM formatted files. The DICOM files were restructured to create 3-D images for further investigation. For publication purposes JPG files of each scanned section were produced imaging the plane representative of the split core surface.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/5w3-p8q-d7l
title: Proboscidea Illiger, 1811

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/eeq-yqs-mqg
title: Mammalia Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.6084/m9.figshare.30415034
title: Dual action of novel 5-nitroguaiacol-based hydrazones: Targeting aldolase-a and inducing apoptosis in lung cancer

description: Building upon previous research on hydrazone-bearing aryloxyacetic acid derivatives, a novel series of 5-nitroguaiacol-based hydrazones (<b>3a–l</b>) was synthesized and characterized spectroscopically. Their <i>in vitro</i> cytotoxic effects were evaluated against human non-small cell lung cancer (A549) and normal bronchial epithelial cell lines (BEAS-2B) using the MTT assay. Compounds <b>3d</b> and <b>3k</b> exhibited selective and potent cytotoxicity (IC<sub>50</sub> = 10.24 µM and 4.99 µM, respectively) and strong aldolase A (ALDOA) inhibition at 10 µM (89.89% and 75.19%). Further mechanistic studies revealed that both compounds decreased HIF-1α expression and modulated apoptotic pathways by upregulating Bax and downregulating Bcl-2 protein levels. Molecular docking studies supported the experimental findings, demonstrating significant interactions of <b>3d</b> and <b>3k</b> with key residues in ALDOA, Bax, and Bcl-2, suggesting a dual mechanism involving glycolysis inhibition and apoptosis induction. These results indicate that <b>3d</b> and <b>3k</b> are promising lead compounds for targeted lung cancer therapy.
DOI: 10.6084/m9.figshare.30415034.v1
title: Dual action of novel 5-nitroguaiacol-based hydrazones: Targeting aldolase-a and inducing apoptosis in lung cancer

description: Building upon previous research on hydrazone-bearing aryloxyacetic acid derivatives, a novel series of 5-nitroguaiacol-based hydrazones (<b>3a–l</b>) was synthesized and characterized spectroscopically. Their <i>in vitro</i> cytotoxic effects were evaluated against human non-small cell lung cancer (A549) and normal bronchial epithelial cell lines (BEAS-2B) using the MTT assay. Compounds <b>3d</b> and <b>3k</b> exhibited selective and potent cytotoxicity (IC<sub>50</sub> = 10.24 µM and 4.99 µM, respectively) and strong aldolase A (ALDOA) inhibition at 10 µM (89.89% and 75.19%). Further mechanistic studies revealed that both compounds decreased HIF-1α expression and modulated apoptotic pathways by upregulating Bax and downregulating Bcl-2 protein levels. Molecular docking studies supported the experimental findings, demonstrating significant interactions of <b>3d</b> and <b>3k</b> with key residues in ALDOA, Bax, and Bcl-2, suggesting a dual mechanism involving glycolysis inhibition and apoptosis induction. These results indicate that <b>3d</b> and <b>3k</b> are promising lead compounds for targeted lung cancer therapy.
DOI: 10.1594/pangaea.977472
title: Moisture and density (MAD) from IODP Hole 386-M0092B

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/77a-adz-b55
title: Equidae Gray, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/cbw-tsq-gzs
title: Ursus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977460
title: Moisture and density (MAD) from IODP Hole 386-M0089B

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.1594/pangaea.977461
title: Moisture and density (MAD) from IODP Hole 386-M0089C

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/9lz-dbd-wfj
title: Hydrochoerus hydrochaeris (Linnaeus, 1766)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lxm-13c-vee
title: Crinoidea Miller, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977444
title: Moisture and density (MAD) from IODP Hole 386-M0084F

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/zm6-5a5-56t
title: Rhinocerotidae Gray, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977473
title: Moisture and density (MAD) from IODP Hole 386-M0092C

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.1594/pangaea.977567
title: X-ray CT images of IODP Hole 386-M0084B

description: Collection of X-ray Computed Tomography (CT) images from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). The offshore phase of this expedition took place between 2021-04-13 and 2021-06-01 onboard Japanese R/V Kaimei from and to Yokosuka, Japan. This was followed by an onshore phase onboard D/V Chikyu between 2022-02-14 – 2022-03-15. X-ray CT scanning was performed on whole-round sections on board D/V Chikyu in July 2021, after the offshore phase and prior to the onshore phase, using a Discovery CT 750HD (GE Medical Systems) that produces 32 0.625 mm thick slice images every 0.4 s. Data generated for each core consist of core-axis-normal planes of X-ray attenuation values that are 512 × 512 pixels in size. Data were stored on the server as DICOM formatted files. The DICOM files were restructured to create 3-D images for further investigation. For publication purposes JPG files of each scanned section were produced imaging the plane representative of the split core surface.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/4dq-k1a-m2e
title: Bryozoa

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vl7-8zr-a9k
title: Cervidae Goldfuss, 1820

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977564
title: X-ray CT images of IODP Hole 386-M0083E

description: Collection of X-ray Computed Tomography (CT) images from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). The offshore phase of this expedition took place between 2021-04-13 and 2021-06-01 onboard Japanese R/V Kaimei from and to Yokosuka, Japan. This was followed by an onshore phase onboard D/V Chikyu between 2022-02-14 – 2022-03-15. X-ray CT scanning was performed on whole-round sections on board D/V Chikyu in July 2021, after the offshore phase and prior to the onshore phase, using a Discovery CT 750HD (GE Medical Systems) that produces 32 0.625 mm thick slice images every 0.4 s. Data generated for each core consist of core-axis-normal planes of X-ray attenuation values that are 512 × 512 pixels in size. Data were stored on the server as DICOM formatted files. The DICOM files were restructured to create 3-D images for further investigation. For publication purposes JPG files of each scanned section were produced imaging the plane representative of the split core surface.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/wyn-m3p-6xp
title: Echinolampas Gray, 1825

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zks-45f-fe1
title: Crinoidea Miller, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977445
title: Moisture and density (MAD) from IODP Hole 386-M0085A

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.1594/pangaea.977462
title: Moisture and density (MAD) from IODP Hole 386-M0089D

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/2ty-dss-psd
title: Elephantidae Gray, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/hqx-789-hpj
title: Rhinocerotidae Gray, 1821

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977446
title: Moisture and density (MAD) from IODP Hole 386-M0085B

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.3535/f9q-fbk-d0f
title: Artiodactyla Owen, 1848

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rgf-78p-2td
title: Artiodactyla Owen, 1848

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.1594/pangaea.977447
title: Moisture and density (MAD) from IODP Hole 386-M0085C

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).
DOI: 10.1594/pangaea.977474
title: Moisture and density (MAD) from IODP Hole 386-M0092D

description: Moisture and density (MAD) data from discrete samples from the above given hole of International Ocean Discovery Program (IODP) Expedition 386 (Japan Trench Paleoseismology). During the onshore phase of expedition 386, which took place between 2022-02-14 – 2022-03-15 onboard D/V Chikyu, discrete samples for MAD measurements (bulk density, dry density, grain density, water content, porosity, and void ratio) were taken from the work halves using 10 cubic centimetre syringes at an approx. down-core resolution of every 2 meters. Sampling depths were adapted and slightly modified for layers of special interest, such as tephras. Samples were processed and measured directly after sampling onboard Chikyu. For the measurements themselves samples were transferred to glass beakers of known weight and volume.For further methodological information see methods chapter in Strasser, M. et al., 2023 https://doi.org/10.14379/iodp.proc.386.102.2023
description: Data was submitted and proofread by Vera Barbara Bender, MARUM - Center for Marine Environmental Sciences (University Bremen) on behalf of ECORD Science Operator Data Management (https://www.ecord.org).