cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21936643
title: Survival analysis of patients with subglottic squamous cell carcinoma based on the SEER database

description: Abstract Objective: This study aimed to investigate the demographic and clinicopathological characteristics, and survival outcomes of subglottic Squamous Cell Carcinoma (SCC) based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods: Demographic and clinicopathological information, including age, sex, race, tumor size, histologic grade, clinical/TNM stage, tumor invasion extent, Lymph Node Metastasis (LNM) extent, size of metastatic lymph nodes, LNM ratio and treatment data, of 842 subglottic SCC patients diagnosed between 1996 and 2016 were acquired. Kaplan-Meier survival analyses were performed to assess the effects of clinicopathological characteristics, treatment modalities, surgical procedures, and adjuvant therapies on overall survival and cancer-specific survival. Results: Subglottic SCC was more frequent among males aged 60-70 years, with low-grade but locally advanced lesions without local or distant metastases. Age and several primary tumor/LNM related variables were independent risk factors for overall survival and cancer specific survival. Advanced-stage and high-grade disease led to unfavorable prognosis. The most common treatment modality and surgical procedure were surgery plus radiotherapy and total laryngectomy, respectively. Surgery plus radiotherapy provided favorable 5-year survival outcomes, while total laryngectomy had the worst. Surgery plus adjuvant therapy showed better survival outcomes than surgery alone. Conclusion: This study confirmed the rarity of subglottic SCC. Patients with subglottic SCCs suffered poor prognosis especially for those with advanced-stage or high-grade lesions. The prognosis of subglottic SCC remained poor over the years, despite recent progress in cancer therapies. Surgery plus adjuvant therapy improved the survival outcome. Although larynx preservation surgery was beneficial for early-stage disease, total laryngectomy was favored for patients with advanced tumors. Level of evidence: Level 4.
DOI: 10.6084/m9.figshare.21936643.v1
title: Survival analysis of patients with subglottic squamous cell carcinoma based on the SEER database

description: Abstract Objective: This study aimed to investigate the demographic and clinicopathological characteristics, and survival outcomes of subglottic Squamous Cell Carcinoma (SCC) based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods: Demographic and clinicopathological information, including age, sex, race, tumor size, histologic grade, clinical/TNM stage, tumor invasion extent, Lymph Node Metastasis (LNM) extent, size of metastatic lymph nodes, LNM ratio and treatment data, of 842 subglottic SCC patients diagnosed between 1996 and 2016 were acquired. Kaplan-Meier survival analyses were performed to assess the effects of clinicopathological characteristics, treatment modalities, surgical procedures, and adjuvant therapies on overall survival and cancer-specific survival. Results: Subglottic SCC was more frequent among males aged 60-70 years, with low-grade but locally advanced lesions without local or distant metastases. Age and several primary tumor/LNM related variables were independent risk factors for overall survival and cancer specific survival. Advanced-stage and high-grade disease led to unfavorable prognosis. The most common treatment modality and surgical procedure were surgery plus radiotherapy and total laryngectomy, respectively. Surgery plus radiotherapy provided favorable 5-year survival outcomes, while total laryngectomy had the worst. Surgery plus adjuvant therapy showed better survival outcomes than surgery alone. Conclusion: This study confirmed the rarity of subglottic SCC. Patients with subglottic SCCs suffered poor prognosis especially for those with advanced-stage or high-grade lesions. The prognosis of subglottic SCC remained poor over the years, despite recent progress in cancer therapies. Surgery plus adjuvant therapy improved the survival outcome. Although larynx preservation surgery was beneficial for early-stage disease, total laryngectomy was favored for patients with advanced tumors. Level of evidence: Level 4.
DOI: 10.6084/m9.figshare.8305178
title: MOESM6 of Metatranscriptomics of the Hu sheep rumen microbiome reveals novel cellulases

description: Additional file 6: Table S4. Best hits of the identified cellulases when compared to the CAZy and NCBI nr databases.
DOI: 10.6084/m9.figshare.8305178.v1
title: MOESM6 of Metatranscriptomics of the Hu sheep rumen microbiome reveals novel cellulases

description: Additional file 6: Table S4. Best hits of the identified cellulases when compared to the CAZy and NCBI nr databases.
DOI: 10.6084/m9.figshare.8305181
title: MOESM7 of Metatranscriptomics of the Hu sheep rumen microbiome reveals novel cellulases

description: Additional file 7: Table S5. Taxonomic annotation of the unigenes encoding CAZymes.
DOI: 10.6084/m9.figshare.8305181.v1
title: MOESM7 of Metatranscriptomics of the Hu sheep rumen microbiome reveals novel cellulases

description: Additional file 7: Table S5. Taxonomic annotation of the unigenes encoding CAZymes.
DOI: 10.6084/m9.figshare.8305193
title: MOESM9 of Metatranscriptomics of the Hu sheep rumen microbiome reveals novel cellulases

description: Additional file 9: Table S7. The FPKM value of the putative ORFs assigned to the GH5 family.
DOI: 10.6084/m9.figshare.8305193.v1
title: MOESM9 of Metatranscriptomics of the Hu sheep rumen microbiome reveals novel cellulases

description: Additional file 9: Table S7. The FPKM value of the putative ORFs assigned to the GH5 family.
DOI: 10.6084/m9.figshare.21936706
title: Impact of radiotherapy for nasopharyngeal carcinoma on carotid stenosis risk: a meta-analysis

description: Abstract Objects: Radiotherapy (RT) serves as the most effective treatment for Nasopharyngeal Carcinoma (NPC) and can cause carotid stenosis. The aim of this study is to assess the impact of RT on carotid stenosis in NPC patients, as well as to explore the risk factors for significant carotid stenosis. Methods: Studies reporting the carotid stenosis in NPC patients who underwent RT were found on PubMed, Embase and Web of Science. Outcomes of our interest included incidence of overall/significant stenosis, Common Carotid Artery (CCA) stenosis, External Carotid Artery (ECA) stenosis, Internal Carotid Artery (ICA) stenosis, and risk factors for significant carotid stenosis. Results: Sixteen studies met the inclusion criteria and were included in this meta-analysis. Pooled estimate showed that RT was associated with a significantly higher incidence of overall stenosis (Risk Ratio [RR = 3.53], 95% CI: 2.32–5.37; p &lt; 0.001) and significant stenosis (RR = 7.06, 95% CI: 3.61–13.79; p &lt; 0.001) as compared with controls. Moreover, patients treated with RT had a significantly higher risk of stenosis in CCA (RR = 6.87, 95% CI: 4.08–11.58; p &lt; 0.001), ICA (RR = 3.43, 95% CI: 1.35–8.73; p= 0.010), ECA (RR = 9.37, 95% CI: 2.06–42.68; p = 0.004), and ECA/ICA (RR = 2.18, 95% CI: 1.52–3.13; p &lt; 0.001). Meta-analysis indicated that age (RR = 1.46, 95% CI: 1.05–2.04; p = 0.024), smoking habit (RR = 1.20, 95% CI: 1.02–2.78; p = 0.045) and time interval from radiotherapy (RR = 1.56, 95% CI: 1.07–2.28; p = 0.02) were independent predictors of significant carotid stenosis. Conclusion: Our results suggested that RT increased the risk of carotid stenosis in patients with NPC. Prevention and control measurements should be made for older NPC patients with longer interval from RT, especially those with smoking habit. Level of evidence: 3.
DOI: 10.6084/m9.figshare.21936706.v1
title: Impact of radiotherapy for nasopharyngeal carcinoma on carotid stenosis risk: a meta-analysis

description: Abstract Objects: Radiotherapy (RT) serves as the most effective treatment for Nasopharyngeal Carcinoma (NPC) and can cause carotid stenosis. The aim of this study is to assess the impact of RT on carotid stenosis in NPC patients, as well as to explore the risk factors for significant carotid stenosis. Methods: Studies reporting the carotid stenosis in NPC patients who underwent RT were found on PubMed, Embase and Web of Science. Outcomes of our interest included incidence of overall/significant stenosis, Common Carotid Artery (CCA) stenosis, External Carotid Artery (ECA) stenosis, Internal Carotid Artery (ICA) stenosis, and risk factors for significant carotid stenosis. Results: Sixteen studies met the inclusion criteria and were included in this meta-analysis. Pooled estimate showed that RT was associated with a significantly higher incidence of overall stenosis (Risk Ratio [RR = 3.53], 95% CI: 2.32–5.37; p &lt; 0.001) and significant stenosis (RR = 7.06, 95% CI: 3.61–13.79; p &lt; 0.001) as compared with controls. Moreover, patients treated with RT had a significantly higher risk of stenosis in CCA (RR = 6.87, 95% CI: 4.08–11.58; p &lt; 0.001), ICA (RR = 3.43, 95% CI: 1.35–8.73; p= 0.010), ECA (RR = 9.37, 95% CI: 2.06–42.68; p = 0.004), and ECA/ICA (RR = 2.18, 95% CI: 1.52–3.13; p &lt; 0.001). Meta-analysis indicated that age (RR = 1.46, 95% CI: 1.05–2.04; p = 0.024), smoking habit (RR = 1.20, 95% CI: 1.02–2.78; p = 0.045) and time interval from radiotherapy (RR = 1.56, 95% CI: 1.07–2.28; p = 0.02) were independent predictors of significant carotid stenosis. Conclusion: Our results suggested that RT increased the risk of carotid stenosis in patients with NPC. Prevention and control measurements should be made for older NPC patients with longer interval from RT, especially those with smoking habit. Level of evidence: 3.
DOI: 10.6084/m9.figshare.13023849
title: Additional file 14 of Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

description: Additional file 14: Material S5. Matching 3587 small molecules drugs by CMap database.
DOI: 10.6084/m9.figshare.13023849.v1
title: Additional file 14 of Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

description: Additional file 14: Material S5. Matching 3587 small molecules drugs by CMap database.
DOI: 10.6084/m9.figshare.13023852
title: Additional file 1 of Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

description: Additional file 1: Material S1. Clinical information data of 117 LSCC samples from TCGA database.
DOI: 10.6084/m9.figshare.13023852.v1
title: Additional file 1 of Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

description: Additional file 1: Material S1. Clinical information data of 117 LSCC samples from TCGA database.
DOI: 10.6084/m9.figshare.13023864
title: Additional file 5 of Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

description: Additional file 5: Material S4. Identification of 88 methylation-driven genes with Cor &lt;−0.3, |logFC| &gt; 0and P &lt; 0.05.
DOI: 10.6084/m9.figshare.13023864.v1
title: Additional file 5 of Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

description: Additional file 5: Material S4. Identification of 88 methylation-driven genes with Cor &lt;−0.3, |logFC| &gt; 0and P &lt; 0.05.
DOI: 10.6084/m9.figshare.21936760
title: Outcomes of endoscopic and open resection of sinonasal malignancies: a systematic review and meta-analysis

description: Abstract Objective: To compare the efficacy of endoscopic and open resection of sinonasal malignancies. Methods: The search was performed using PubMed (1950–2020), Embase (1974–2020), the Cochrane library, and the website clinicaltrials.gov. The hazard ratio, HR, 95% confidence interval, CI, of the rates of overall survival and disease-free survival and the demographic characteristics of the included studies were extracted and analyzed. Pooled analysis was conducted with the studies’ individual patient data, using log-rank test, Kaplan-Meier survival, and Cox regression analysis. Results: Of 1939 articles retrieved, 23 articles were included. Overall, 1373 cases were incorporated into the final analysis, 653 (47.56%) of which underwent the surgery through an endoscopic approach, whereas 720 (52.44%) cases utilized the open approach. The overall survival was comparable between endoscopic and open resection (HR = 0.84 [95% CI: 0.65–1.07], p = 0.16; random effects analysis). Pooled analysis with Cox regression revealed significant differences in overall survival (HR = 0.568 [95%CI:0.380-0.849], p = 0.006) and disease-free survival (HR = 0.628 [95%CI:0.424-0.929], p = 0.02) between endoscopic and open approaches. Conclusion: The aggregated evidence suggests the survival outcome of endoscopic resection is comparable or greater than that of open resection of sinonasal malignancies.
DOI: 10.6084/m9.figshare.21936760.v1
title: Outcomes of endoscopic and open resection of sinonasal malignancies: a systematic review and meta-analysis

description: Abstract Objective: To compare the efficacy of endoscopic and open resection of sinonasal malignancies. Methods: The search was performed using PubMed (1950–2020), Embase (1974–2020), the Cochrane library, and the website clinicaltrials.gov. The hazard ratio, HR, 95% confidence interval, CI, of the rates of overall survival and disease-free survival and the demographic characteristics of the included studies were extracted and analyzed. Pooled analysis was conducted with the studies’ individual patient data, using log-rank test, Kaplan-Meier survival, and Cox regression analysis. Results: Of 1939 articles retrieved, 23 articles were included. Overall, 1373 cases were incorporated into the final analysis, 653 (47.56%) of which underwent the surgery through an endoscopic approach, whereas 720 (52.44%) cases utilized the open approach. The overall survival was comparable between endoscopic and open resection (HR = 0.84 [95% CI: 0.65–1.07], p = 0.16; random effects analysis). Pooled analysis with Cox regression revealed significant differences in overall survival (HR = 0.568 [95%CI:0.380-0.849], p = 0.006) and disease-free survival (HR = 0.628 [95%CI:0.424-0.929], p = 0.02) between endoscopic and open approaches. Conclusion: The aggregated evidence suggests the survival outcome of endoscopic resection is comparable or greater than that of open resection of sinonasal malignancies.
DOI: 10.6084/m9.figshare.21936766
title: Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review

description: Abstract Objective: The aim of this study was to report 6 cases of sinonasal/basicranial myxofibrosarcoma and review demographic data, clinical symptoms, diagnostic methods, therapeutic methods, and prognosis on this subject in the literature. Methods: We conducted a retrospective analysis of six patients referred to our hospital during a 10-year period from 2010 to 2020. Results: In this series, there were four males and two females. The tumours originated from the maxillary sinus in all six cases. The symptoms were nonspecific, and all patients underwent endoscopic resection alone or combined with open resection. The postoperative period was uneventful. All patients were diagnosed with myxofibrosarcoma. After a median follow-up period of 36 (6–52) months, the recurrence rate of MFS was 66.7% (4/6), and the mortality rate was 50% (3/6). Conclusion: Sinonasal/basicranial MFS is a rare neoplasm, and the most common primary site is the maxillary sinus. When diagnosing MFS, osteolysis may help rule out benign lesions. So far surgery is the mainstay of treatment for sinonasal/basicranial MFS. Our surgical strategy using endoscopic resection or endoscopic resection combined with open resection to achieve a negative surgical margin and using re-excision operations to treat relapsed cases may be recommended to rhinologists who treat MFS. Prospective randomised trials are needed to study the role of chemotherapy, radiotherapy, and our surgical strategy for sinonasal/basicranial MFS. Diagnosing patients at an earlier stage and better patient compliance with follow-up plans may improve the prognosis of patients.
DOI: 10.6084/m9.figshare.21936766.v1
title: Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review

description: Abstract Objective: The aim of this study was to report 6 cases of sinonasal/basicranial myxofibrosarcoma and review demographic data, clinical symptoms, diagnostic methods, therapeutic methods, and prognosis on this subject in the literature. Methods: We conducted a retrospective analysis of six patients referred to our hospital during a 10-year period from 2010 to 2020. Results: In this series, there were four males and two females. The tumours originated from the maxillary sinus in all six cases. The symptoms were nonspecific, and all patients underwent endoscopic resection alone or combined with open resection. The postoperative period was uneventful. All patients were diagnosed with myxofibrosarcoma. After a median follow-up period of 36 (6–52) months, the recurrence rate of MFS was 66.7% (4/6), and the mortality rate was 50% (3/6). Conclusion: Sinonasal/basicranial MFS is a rare neoplasm, and the most common primary site is the maxillary sinus. When diagnosing MFS, osteolysis may help rule out benign lesions. So far surgery is the mainstay of treatment for sinonasal/basicranial MFS. Our surgical strategy using endoscopic resection or endoscopic resection combined with open resection to achieve a negative surgical margin and using re-excision operations to treat relapsed cases may be recommended to rhinologists who treat MFS. Prospective randomised trials are needed to study the role of chemotherapy, radiotherapy, and our surgical strategy for sinonasal/basicranial MFS. Diagnosing patients at an earlier stage and better patient compliance with follow-up plans may improve the prognosis of patients.
DOI: 10.15468/rjq95m
title: 2019_BIOTOPE_4

description: 2019_BIOTOPE_LeThoronet:BIOTOPE
DOI: 10.15468/zxsx4t
title: 2018_PROSERPINE_7

description: 2018_PROSERPINE_DE-PINHO:PROSERPINE
DOI: 10.15468/cxexxs
title: 2021 - Demande d'autorisation environnementale pour l'extension et le renouvellement de la carrière de la société Saviane Frères sur la commune de Beaunotte (21) de matériaux calcaires - Amphibiens inventoriés par ENCEM sur la carrière de Beaunotte en 2018

description: Amphibiens inventoriés au fil de deux soirées d'inventaires entre mars et juin 2018
DOI: 10.15468/sdphf5
title: 2020_Parc National de Port Cros_2

description: 2019_PNPC_Annelides:Parc National de Port Cros
DOI: 10.6084/m9.figshare.20363976
title: Additional file 2 of Seminal plasma extracellular vesicles tRF-Val-AAC-010 can serve as a predictive factor of successful microdissection testicular sperm extraction in patients with non-obstructive azoospermia

description: Additional file 2: Supplementary Table 1. The baseline clinical disease characteristics of NOA, OA, IO and control samples.
DOI: 10.6084/m9.figshare.20363976.v1
title: Additional file 2 of Seminal plasma extracellular vesicles tRF-Val-AAC-010 can serve as a predictive factor of successful microdissection testicular sperm extraction in patients with non-obstructive azoospermia

description: Additional file 2: Supplementary Table 1. The baseline clinical disease characteristics of NOA, OA, IO and control samples.
DOI: 10.6084/m9.figshare.20363994
title: Additional file 6 of Seminal plasma extracellular vesicles tRF-Val-AAC-010 can serve as a predictive factor of successful microdissection testicular sperm extraction in patients with non-obstructive azoospermia

description: Additional file 6: Supplementary Table 5. Target genes of tRF-Pro-AGG-003 and tRF-Val-AAC-010 enriched in the testis.
DOI: 10.6084/m9.figshare.20363994.v1
title: Additional file 6 of Seminal plasma extracellular vesicles tRF-Val-AAC-010 can serve as a predictive factor of successful microdissection testicular sperm extraction in patients with non-obstructive azoospermia

description: Additional file 6: Supplementary Table 5. Target genes of tRF-Pro-AGG-003 and tRF-Val-AAC-010 enriched in the testis.
DOI: 10.6084/m9.figshare.8305373
title: Additional file 5: of Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis

description: Table S2. Clinical summary of subjects studied. The table lists the subjects used in the study, their BMI, age, sex and 4-h gastric retention. ND-not determined. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.8305373.v1
title: Additional file 5: of Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis

description: Table S2. Clinical summary of subjects studied. The table lists the subjects used in the study, their BMI, age, sex and 4-h gastric retention. ND-not determined. (XLSX 37 kb)
DOI: 10.6084/m9.figshare.8305388
title: Additional file 8: of Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis

description: Table S5. List of genes in each segment of the Venn Diagram shown in Fig. 6. (XLS 63 kb)
DOI: 10.6084/m9.figshare.8305388.v1
title: Additional file 8: of Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis

description: Table S5. List of genes in each segment of the Venn Diagram shown in Fig. 6. (XLS 63 kb)
DOI: 10.6084/m9.figshare.21936881
title: Table S1 from Who will name new plant species? Temporal change in the origins of taxonomists in China

description: Details of species and taxonmists
DOI: 10.6084/m9.figshare.21936881.v1
title: Table S1 from Who will name new plant species? Temporal change in the origins of taxonomists in China

description: Details of species and taxonmists
DOI: 10.6084/m9.figshare.20364021
title: Additional file 4 of Transcriptome and co-expression network analyses of key genes and pathways associated with differential abscisic acid accumulation during maize seed maturation

description: Additional file 4: Table S4. Genes identified mediumpurple3 module.
DOI: 10.6084/m9.figshare.20364021.v1
title: Additional file 4 of Transcriptome and co-expression network analyses of key genes and pathways associated with differential abscisic acid accumulation during maize seed maturation

description: Additional file 4: Table S4. Genes identified mediumpurple3 module.
DOI: 10.6084/m9.figshare.20364005
title: Additional file 3 of Efficient management of the nitritation-anammox microbiome through intermittent aeration: absence of the NOB guild and expansion and diversity of the NOx reducing guild suggests a highly reticulated nitrogen cycle

description: Additional file 3: Table S2: Overview of the genetic content of the recovered metagenome-assembled genomes.
DOI: 10.6084/m9.figshare.20364005.v1
title: Additional file 3 of Efficient management of the nitritation-anammox microbiome through intermittent aeration: absence of the NOB guild and expansion and diversity of the NOx reducing guild suggests a highly reticulated nitrogen cycle

description: Additional file 3: Table S2: Overview of the genetic content of the recovered metagenome-assembled genomes.