cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6507029
title: Dataset for: Diltiazem improves contractile properties of skeletal muscle in dysferlin-deficient BLAJ mice, but does not reduce contraction-induced muscle damage

description: B6.A-<i>Dysf</i><i><sup>prmd</sup></i>/GeneJ (BLAJ) mice model human limb-girdle muscular dystrophy 2B (LGMD2B), which is linked to mutations in the dysferlin (DYSF) gene. We tested the hypothesis that, the calcium ion (Ca2+) channel blocker diltiazem (DTZ), reduces contraction-induced skeletal muscle damage, in BLAJ mice. We randomly assigned mice (N = 12; 3 - 4 m old males) to one of two groups – DTZ (N = 6) or vehicle (VEH, distilled water, N = 6). We conditioned mice with either DTZ or VEH for 1 wk, after which, their tibialis anterior (TA) muscles were tested for contractile torque and susceptibility to injury from forced eccentric contractions. We continued dosing with DTZ or VEH for 3 days following eccentric contractions, and then studied torque recovery and muscle damage. We analyzed contractile torque before eccentric contractions, immediately after eccentric contractions, and at 3 days after eccentric contractions; and counted damaged fibers in the injured and uninjured TA muscles. We found that DTZ improved contractile torque before and immediately after forced eccentric contractions, but did not reduce delayed-onset muscle damage that was observed at 3 days after eccentric contractions.
DOI: 10.6084/m9.figshare.6507029.v1
title: Dataset for: Diltiazem improves contractile properties of skeletal muscle in dysferlin-deficient BLAJ mice, but does not reduce contraction-induced muscle damage

description: B6.A-<i>Dysf</i><i><sup>prmd</sup></i>/GeneJ (BLAJ) mice model human limb-girdle muscular dystrophy 2B (LGMD2B), which is linked to mutations in the dysferlin (DYSF) gene. We tested the hypothesis that, the calcium ion (Ca2+) channel blocker diltiazem (DTZ), reduces contraction-induced skeletal muscle damage, in BLAJ mice. We randomly assigned mice (N = 12; 3 - 4 m old males) to one of two groups – DTZ (N = 6) or vehicle (VEH, distilled water, N = 6). We conditioned mice with either DTZ or VEH for 1 wk, after which, their tibialis anterior (TA) muscles were tested for contractile torque and susceptibility to injury from forced eccentric contractions. We continued dosing with DTZ or VEH for 3 days following eccentric contractions, and then studied torque recovery and muscle damage. We analyzed contractile torque before eccentric contractions, immediately after eccentric contractions, and at 3 days after eccentric contractions; and counted damaged fibers in the injured and uninjured TA muscles. We found that DTZ improved contractile torque before and immediately after forced eccentric contractions, but did not reduce delayed-onset muscle damage that was observed at 3 days after eccentric contractions.
DOI: 10.6084/m9.figshare.24031935
title: Coverage and mapping metrics summary

description: Sample coverage (section A). Section B summarizes mapping metrics for double stranded and single stranded libraries. The mapping metrics of preliminary sequencing of double stranded libraries on 1/8 of a lane on a HiSeq2500 is summarized on section C. The mapping metrics for the contemporary sample (2018) are shown on section D.
DOI: 10.6084/m9.figshare.24031935.v1
title: Coverage and mapping metrics summary

description: Sample coverage (section A). Section B summarizes mapping metrics for double stranded and single stranded libraries. The mapping metrics of preliminary sequencing of double stranded libraries on 1/8 of a lane on a HiSeq2500 is summarized on section C. The mapping metrics for the contemporary sample (2018) are shown on section D.
DOI: 10.57841/casdc.0001952
title: 微量第二润滑介质辅助的增强水润滑研究
DOI: 10.6084/m9.figshare.21229439
title: The potential of using biosynthetic metabolites of entomopathogenic bacteria in the mitigation of the amphibian disease chytridiomycosis

description: Chytridiomycosis, caused by the chytrid fungus <em>Batrachochytrium dendrobatidis</em> (Bd), has caused extreme losses in amphibian biodiversity. Finding bacteria that produce metabolites with antifungal properties for the purpose of disease mitigation may turn out to be invaluable in the fight against chytridiomycosis. The entomopathogenic bacteria, <em>Xenorhabdus szentirmaii</em> and <em>X. budapestensis</em> produce secondary metabolites that are effective against a wide range of fungal plant pathogens. To assess whether they may also be effective against Bd, we extracted cell-free culture media (CFCM) from liquid cultures of <em>X. szentirmaii</em> and <em>X. budapestensis</em> and tested their ability to inhibit Bd growth <em>in vitro</em>. As a second step, we experimentally infected juvenile common toads (<em>Bufo bufo</em>) with Bd and also tested the <em>in vivo</em> disinfecting efficacy of <em>X. szentirmaii</em> CFCM diluted to 2 and 10% (v/v), while also assessing possible malign side effects on amphibians. Minimal inhibitory dilutions by CFCMs of both <em>Xenorhabdus</em> species were between 0.78 and 1.58% (v/v). The <em>in vivo</em> experiment showed that treatment with CFCM of <em>X. szentirmaii</em> applied at a dilution of 10% resulted in infection intensities reduced by ca. 73% relative to controls and to juvenile toads treated with CFCM applied at a dilution of 2%. At the same time, we detected no negative side effects of treatment with CFCM on survival, body mass, and skin microbial community of juvenile toads. Our results clearly support the idea that <em>X. szentirmaii</em> metabolites may prove safe and highly useful in the fight against chytridiomycosis, and that future research following this promising avenue has high potential of resulting in an effective, safe, and cheap method of Bd disinfection.
DOI: 10.6084/m9.figshare.21229439.v1
title: The potential of using biosynthetic metabolites of entomopathogenic bacteria in the mitigation of the amphibian disease chytridiomycosis

description: Chytridiomycosis, caused by the chytrid fungus <em>Batrachochytrium dendrobatidis</em> (Bd), has caused extreme losses in amphibian biodiversity. Finding bacteria that produce metabolites with antifungal properties for the purpose of disease mitigation may turn out to be invaluable in the fight against chytridiomycosis. The entomopathogenic bacteria, <em>Xenorhabdus szentirmaii</em> and <em>X. budapestensis</em> produce secondary metabolites that are effective against a wide range of fungal plant pathogens. To assess whether they may also be effective against Bd, we extracted cell-free culture media (CFCM) from liquid cultures of <em>X. szentirmaii</em> and <em>X. budapestensis</em> and tested their ability to inhibit Bd growth <em>in vitro</em>. As a second step, we experimentally infected juvenile common toads (<em>Bufo bufo</em>) with Bd and also tested the <em>in vivo</em> disinfecting efficacy of <em>X. szentirmaii</em> CFCM diluted to 2 and 10% (v/v), while also assessing possible malign side effects on amphibians. Minimal inhibitory dilutions by CFCMs of both <em>Xenorhabdus</em> species were between 0.78 and 1.58% (v/v). The <em>in vivo</em> experiment showed that treatment with CFCM of <em>X. szentirmaii</em> applied at a dilution of 10% resulted in infection intensities reduced by ca. 73% relative to controls and to juvenile toads treated with CFCM applied at a dilution of 2%. At the same time, we detected no negative side effects of treatment with CFCM on survival, body mass, and skin microbial community of juvenile toads. Our results clearly support the idea that <em>X. szentirmaii</em> metabolites may prove safe and highly useful in the fight against chytridiomycosis, and that future research following this promising avenue has high potential of resulting in an effective, safe, and cheap method of Bd disinfection.
DOI: 10.5281/zenodo.8281102
title: Synthesis of National projects on Aviation noise gathered by ANIMA National Focal Points

description: This bundle gathers synthetic informations on more than hundred projects led at national level in EU countries and their neighbourhood (Switzeland, Ukraine, Serbia...) on aviation noise. This projects are partaking to the EU efforts to update the European Research Roadmap on such aviation noise issues. The bundle has been used for elaboration deliverable ANIMA D6.10 - National Focal Points projects
DOI: 10.5281/zenodo.8281129
title: Annotation of inverted repeats displaying features of pble STIR or IR in the hg38 genome model

description: Annotation of inverted repeats displaying features of pble STIR or IR in the hg38 genome model. The annotation of <em>pble</em>-like inner inverted repeats was done using Palindrome (EMBOSS package). The output file was then filtered using pal2gff (https://github.com/Leelouh/pal2gff/blob/main/pal2gff.py), using as parameters a repeat size between 5 and 15 nucleotides, a spacer between pairs of inverted repeats (IRs) of 2 to 10 nucleotides, and a number of mismatches within repeats ranging from 0 to 1. These parameters were chosen taking into account those of the inner IRs found at ends of invertebrate pbles.
DOI: 10.5281/zenodo.8281128
title: Annotation of inverted repeats displaying features of pble STIR or IR in the hg38 genome model

description: Annotation of inverted repeats displaying features of pble STIR or IR in the hg38 genome model. The annotation of <em>pble</em>-like inner inverted repeats was done using Palindrome (EMBOSS package). The output file was then filtered using pal2gff (https://github.com/Leelouh/pal2gff/blob/main/pal2gff.py), using as parameters a repeat size between 5 and 15 nucleotides, a spacer between pairs of inverted repeats (IRs) of 2 to 10 nucleotides, and a number of mismatches within repeats ranging from 0 to 1. These parameters were chosen taking into account those of the inner IRs found at ends of invertebrate pbles.
DOI: 10.57841/casdc.0001953
title: 对甲苯酚-AOT双组份超分子凝胶的制备及摩擦学性能研究
DOI: 10.6084/m9.figshare.24031929
title: metabolomics analysis of <i>Edwardsiella tarda</i>

description: According to metabolomic analysis, exogenous glutamate could change metabolism state of E.tarda
DOI: 10.6084/m9.figshare.24031929.v2
title: metabolomics analysis of <i>Edwardsiella tarda</i>

description: According to metabolomic analysis, exogenous glutamate could change metabolism state of E.tarda
DOI: 10.6084/m9.figshare.24031929.v1
title: metabolomics analysis of <i>Edwardsiella tarda</i>

description: According to metabolomic analysis, exogenous glutamate could change metabolism state of E.tarda
DOI: 10.5281/zenodo.8281170
title: MCT1 gene silencing enhances the immune effect of dendritic cells on cervical cancer cells

description: Statistics for Figure 1-6. <strong>Figure S1</strong> Cube maps for the levels of expression for DC markers after sLA exposure and LPS challenge. DCs were first infected with Ad-shCtrl and Ad-shMCT1 adenoviruses for 24 h, then co-cultured with 50 mM sLA or PBS for 48 h, and finally stimulated with 1 ug/mL LPS for 24 h. Flow cytometry was used to detect the expression of CD1a (A), CD80 (B), CD83 (C), CD86 (D) and MHCII (E) in DCs. The column height represents the average value, and the bar of the column is the standard deviation. P value was calculated by Tukey’s honestly significant difference (HSD) test following analysis of variance (ANOVA) testing between multiple groups or by Student's t test between (PBS vs sLA treatment Table S1. Statistics for Figure S1.
DOI: 10.5281/zenodo.8281169
title: MCT1 gene silencing enhances the immune effect of dendritic cells on cervical cancer cells

description: Statistics for Figure 1-6. <strong>Figure S1</strong> Cube maps for the levels of expression for DC markers after sLA exposure and LPS challenge. DCs were first infected with Ad-shCtrl and Ad-shMCT1 adenoviruses for 24 h, then co-cultured with 50 mM sLA or PBS for 48 h, and finally stimulated with 1 ug/mL LPS for 24 h. Flow cytometry was used to detect the expression of CD1a (A), CD80 (B), CD83 (C), CD86 (D) and MHCII (E) in DCs. The column height represents the average value, and the bar of the column is the standard deviation. P value was calculated by Tukey’s honestly significant difference (HSD) test following analysis of variance (ANOVA) testing between multiple groups or by Student's t test between (PBS vs sLA treatment Table S1. Statistics for Figure S1.
DOI: 10.57841/casdc.0001954
title: 羽状氮化碳水润滑剂对环氧树脂-不锈钢配副摩擦学性能的影响
DOI: 10.5281/zenodo.8281103
title: Synthesis of National projects on Aviation noise gathered by ANIMA National Focal Points

description: This bundle gathers synthetic informations on more than hundred projects led at national level in EU countries and their neighbourhood (Switzeland, Ukraine, Serbia...) on aviation noise. This projects are partaking to the EU efforts to update the European Research Roadmap on such aviation noise issues. The bundle has been used for elaboration deliverable ANIMA D6.10 - National Focal Points projects
DOI: 10.57841/casdc.0001955
title: 基于颗粒物质力学的铁粉末压制中摩擦特性对力链演化影响
DOI: 10.5281/zenodo.8276098
title: Electron microscopy data for Hopfion rings in a cubic chiral magnet

description: Raw data for Figures shown in the main text and Extended Data Figs 1-4 are provided here. Data is provided in *.dm4 format, which can be opened by Gatan Microscopy Suite (GMS) software 3.4.
DOI: 10.5281/zenodo.8276097
title: Electron microscopy data for Hopfion rings in a cubic chiral magnet

description: Raw data for Figures shown in the main text and Extended Data Figs 1-4 are provided here. Data is provided in *.dm4 format, which can be opened by Gatan Microscopy Suite (GMS) software 3.4.
DOI: 10.5281/zenodo.8281078
title: Electron microscopy data for Hopfion rings in a cubic chiral magnet

description: Raw data for Figures shown in the main text and Extended Data Figs 1-4 are provided here. Data is provided in *.dm4 format, which can be opened by Gatan Microscopy Suite (GMS) software 3.4.
DOI: 10.6084/m9.figshare.24032001
title: Untitled Item

description: Database for Ferroelectric-defined reconfigurable homojunctions for in-memory sensing and computing
DOI: 10.34740/kaggle/dsv/6362128
title: Kenya's Agricultural Production (1960-2022)
DOI: 10.5281/zenodo.8281116
title: Proteomic detection of COX-2 pathway-related factors in patients with adenomyosis

description: Peptide, protein, protein_merge_info and psm are part of mass spectrometry. HE and LE, only LE and only HE are part of bioinformatics analysis.
DOI: 10.5281/zenodo.8281115
title: Proteomic detection of COX-2 pathway-related factors in patients with adenomyosis

description: Peptide, protein, protein_merge_info and psm are part of mass spectrometry. HE and LE, only LE and only HE are part of bioinformatics analysis.
DOI: 10.57841/casdc.0001956
title: 石墨表面金属包覆处理对Cu基粉末冶金摩擦材料制动摩擦学行为的影响
DOI: 10.5517/ccdc.csd.cc21k3j8
title: CCDC 1893279: Experimental Crystal Structure Determination

description: Related Article: Debanjana Biswal, Nikhil Ranjan Pramanik, Michael G. B. Drew, Nancy Jangra, Mannar R. Maurya, Mousumi Kundu, Parames C. Sil, Syamal Chakrabarti|2019|New J.Chem.|43|17783|doi:10.1039/C9NJ02471A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc21zh1l
title: CCDC 1906129: Experimental Crystal Structure Determination

description: Related Article: Adriana Lugosan, Thomas Cundari, Kristin Fleming, Diane A. Dickie, Matthias Zeller, Jack Ghannam, Wei-Tsung Lee|2020|Dalton Trans.|49|1200|doi:10.1039/C9DT04544A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc21zh2m
title: CCDC 1906130: Experimental Crystal Structure Determination

description: Related Article: Adriana Lugosan, Thomas Cundari, Kristin Fleming, Diane A. Dickie, Matthias Zeller, Jack Ghannam, Wei-Tsung Lee|2020|Dalton Trans.|49|1200|doi:10.1039/C9DT04544A
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc23gb1z
title: CCDC 1950180: Experimental Crystal Structure Determination

description: Related Article: Saraswathi Kothandan, Krishnan Thirumoorthy, Antonio Rodriquez-Diequez, Angappan Sheela|2022|Bioinorg.Chem.Appl.|2022|8696420|doi:10.1155/2022/8696420
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2935m7
title: CCDC 2118218: Experimental Crystal Structure Determination

description: Related Article: Snehasish Debnath, Pabitra B. Chatterjee|2022|Chem.Commun.|58|9006|doi:10.1039/D2CC03392E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2935p9
title: CCDC 2118220: Experimental Crystal Structure Determination

description: Related Article: Snehasish Debnath, Pabitra B. Chatterjee|2022|Chem.Commun.|58|9006|doi:10.1039/D2CC03392E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c4vgv
title: CCDC 2179407: Experimental Crystal Structure Determination

description: Related Article: Snehasish Debnath, Pabitra B. Chatterjee|2022|Chem.Commun.|58|9006|doi:10.1039/D2CC03392E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2c4z0j
title: CCDC 2179517: Experimental Crystal Structure Determination

description: Related Article: Snehasish Debnath, Pabitra B. Chatterjee|2022|Chem.Commun.|58|9006|doi:10.1039/D2CC03392E
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5281/zenodo.7684899
title: Characterization of signal and transit peptides based on motif composition and taxon-specific patterns

description: These datasets contain supplementary information for the article entitled '<em>Characterization of signal and transit peptides based on motif composition and taxon-specific patterns</em>'. <strong>Abstract</strong> Targeting peptides or presequences are N-terminal extensions of proteins that encode information about their cellular localization. They include signal peptides (SP), which target proteins to the endoplasmic reticulum (ER), and transit peptides (TP) directing proteins to the organelles of endosymbiotic origin: chloroplasts and mitochondria. TPs were hypothesized to have evolved from antimicrobial peptides (AMPs), which are responsible for the host defence against microorganisms, including bacteria, fungi and viruses. In this study, we performed a comprehensive bioinformatic analyses of amino acid motifs of targeting peptides and AMPs using a curated set of experimentally verified proteins. We identified motifs frequently occurring in each type of presequence showing specific patterns associated with their amino acid composition, and investigated their position within the presequence. We also compared motif patterns among different taxonomic groups and identified taxon-specific features, providing some evolutionary insights. Considering the functional relevance and many practical applications of targeting peptides and AMPs, we believe that our analyses will prove useful for their design, and better understanding of protein import mechanism and presequence evolution.