cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.5285/19c70cf4-6972-42e6-8474-1322b220104f
title: Wide diversity in the environmental stress response

description: Three species of Antarctic marine invertebrate: Nacella concinna (limpet), Paraceradocus miersi (crustacean) and Sterechinus neumayeri (urchin) were subjected to three different rates of warming and a two month acclimation trial at 2 degrees Celsius. The rates of warming were 1 degree Celsius per hour, 1 degree Celsius per day and 1 degree Celsius per 3 days. Animals were evaluated to determine whether there was a universal stress response at the cellular level. Funding was provided from the BAS Core Funding, the UKRI Natural Environment Research Council (NERC).
description: Three species of Antarctic marine invertebrate: Nacella concinna (limpet), Paraceradocus miersi (crustacean) and Sterechinus neumayeri (urchin) were collected at 8-15m depth from South Cove near Rothera Research Station, Adelaide Island, Antarctic Peninsula (67° 4' 07" S, 68° 07' 30" W). Size metrics were taken for all animals in this study (length, height and width of shell for Nacella concinna, wet weight for Paraceradocus miersi and test diameter for Sterechinus neumayeri). In the acclimation experiment animals were transferred to aquaria at either control temperature or to aquaria with heaters in to raise the temperature to +2°C. Tank temperatures were recorded daily. The Upper Thermal Limits (UTLs) of a set of control animals at time point 0 were evaluated. This was performed by transferring the animals to a 60 L jacketed tank with aerated sea water at the same temperature as the ambient sea water (0°C) and connected to a thermocirculator (Grant Instruments Ltd, Cambridge, UK). The temperature was raised at 1°C per hour with the temperature limit of each animal noted when they no longer responded to tactile stimuli. This UTL test was repeated at the end of the 2 month period, using the same methodology described above with animals which had been kept at 0°C (control) temperatures for 2 months and also animals which had been kept at 2°C. In the case of the latter, the UTL start temperature was 2°C. In the thermal ramping experiments animals were transferred to a 60 L jacketed tank with aerated sea water at the same temperature as the ambient sea water (0°C) and connected to a thermocirculator (Grant Instruments Ltd, Cambridge, UK). The temperature was raised at either 1°C per hour, 1°C per day or 1°C per 3 days and the animals sampled at a temperature 10% lower than their previously evaluated UTLs at that particular rate of change. For the longer term experiments (1°C per day or 1°C per 3 days), control animals were sampled at time point 0 and at the end of the experiment. For the 1°C per hour, only one set of controls was needed.
DOI: 10.6084/m9.figshare.7149464
title: Semantic and psychometric validation of the Brazilian Portuguese version (PASE-P) of the Psoriatic Arthritis Screening and Evaluation questionnaire

description: Data bank with the data obtained at each university with the information of sex, age, time of dermatological disease in years, type of psoriasis diagnosed, disease activity index of psoriasis, ongoing psoriasis treatment, if there was diagnosis of psoriatic arthritis, symptomatic or traditional psoriatic arthritis drugs, whether there were comorbidities, whether the condition was more peripheral or axial, and the sum of the outcome of the study questionnaire after the patients' response.
DOI: 10.7284/109439
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS1217 using a Raytheon 300 WAAS instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7149455
title: Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin

description: <b>Context:</b> Quercetin exerts antiproliferative effects on gastric cancer. However, its mechanisms of action on gastric cancer have not been comprehensively revealed. <b>Objective:</b> We investigated the mechanisms of action of quercetin against gastric cancer cells. <b>Materials and methods:</b> Human NCI-N87 gastric cancer cells were treated with 15 μM quercetin or dimethyl sulfoxide (as a control) for 48 h. DNA isolated from cells was sequenced on a HiSeq 2500, and the data were used to identify differentially expressed genes (DEGs) between groups. Then, enrichment analyses were performed for DEGs and a protein–protein interaction (PPI) network was constructed. Finally, the transcription factors (TFs)-DEGs regulatory network was visualized by Cytoscape software. <b>Results:</b> A total of 121 DEGs were identified in the quercetin group. In the PPI network, Fos proto-oncogene (FOS, degree = 12), aryl hydrocarbon receptor (AHR, degree = 12), Jun proto-oncogene (JUN, degree = 11), and cytochrome P450 family 1 subfamily A member 1 (CYP1A1, degree = 11) with higher degrees highly interconnected with other proteins. Of the 5 TF-DEGs, early growth response 1 (<i>EGR1)</i>, FOS like 1 (<i>FOSL1</i>), <i>FOS</i>, and <i>JUN</i> were upregulated, while <i>AHR</i> was downregulated. Moreover, <i>FOSL1</i>, <i>JUN</i>, and Wnt family member 7B (<i>WNT7B</i>) were enriched in the Wnt signaling pathway. <b>Discussion and conclusions:</b> CYP1A1 highly interconnected with AHR in the PPI network. Therefore, <i>FOS</i>, <i>AHR</i>, <i>JUN</i>, <i>CYP1A1</i>, <i>EGR1</i>, <i>FOSL1</i>, and <i>WNT7B</i> might be targets of quercetin in gastric cancer.
DOI: 10.6084/m9.figshare.7149455.v1
title: Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin

description: <b>Context:</b> Quercetin exerts antiproliferative effects on gastric cancer. However, its mechanisms of action on gastric cancer have not been comprehensively revealed. <b>Objective:</b> We investigated the mechanisms of action of quercetin against gastric cancer cells. <b>Materials and methods:</b> Human NCI-N87 gastric cancer cells were treated with 15 μM quercetin or dimethyl sulfoxide (as a control) for 48 h. DNA isolated from cells was sequenced on a HiSeq 2500, and the data were used to identify differentially expressed genes (DEGs) between groups. Then, enrichment analyses were performed for DEGs and a protein–protein interaction (PPI) network was constructed. Finally, the transcription factors (TFs)-DEGs regulatory network was visualized by Cytoscape software. <b>Results:</b> A total of 121 DEGs were identified in the quercetin group. In the PPI network, Fos proto-oncogene (FOS, degree = 12), aryl hydrocarbon receptor (AHR, degree = 12), Jun proto-oncogene (JUN, degree = 11), and cytochrome P450 family 1 subfamily A member 1 (CYP1A1, degree = 11) with higher degrees highly interconnected with other proteins. Of the 5 TF-DEGs, early growth response 1 (<i>EGR1)</i>, FOS like 1 (<i>FOSL1</i>), <i>FOS</i>, and <i>JUN</i> were upregulated, while <i>AHR</i> was downregulated. Moreover, <i>FOSL1</i>, <i>JUN</i>, and Wnt family member 7B (<i>WNT7B</i>) were enriched in the Wnt signaling pathway. <b>Discussion and conclusions:</b> CYP1A1 highly interconnected with AHR in the PPI network. Therefore, <i>FOS</i>, <i>AHR</i>, <i>JUN</i>, <i>CYP1A1</i>, <i>EGR1</i>, <i>FOSL1</i>, and <i>WNT7B</i> might be targets of quercetin in gastric cancer.
DOI: 10.6084/m9.figshare.7149173
title: Bidirectional Collaborations in an Intervention Randomized Controlled Trial Performed in the Swedish Early Childhood Education Context

description: Within the field of developmental science, there is a general agreement of the need to work together across academic disciplinary boundaries in order to advance the understandings of how to optimize child development and learning. However, experience also shows that such collaborations may be challenging. This paper reports on the experiences of bidirectional collaboration between researchers in a multidisciplinary research team and between researchers and stakeholders, in the first randomized controlled trial in Swedish preschool. The objective of the trial was to investigate the effects of two pedagogical learning strategies evaluating language, communication, attention, executive functions and early math. The interdisciplinary team includes researchers from early childhood education, linguistics, developmental psychology and cognitive neuro science. Educational researchers and theorists within the field of early childhood education in Sweden have during the last two decades mainly undertaken small-scale qualitative praxis-oriented and participative research. There is a widespread skepticism with regards to some of the core principles in controlled intervention methodologies, including a strong resistance towards individual testing of children. Consequently unanticipated disagreements and conflicts arose within the research team, as RCT methodology requires the measurement of effects pre and post the intervention. The aim of this article is to discuss the conditions for bidirectional collaboration both between researchers and stakeholders and between researchers in the research team. The findings illustrate strategies and negotiations that emerged in order to address ontological and epistemological controversies and disagreements. These include (a) the negotiation of research ethics, (b) making divergences visible and learning from each other, (c) using a multi-epistemological and methodological approach as a complement to the RCT design and (d) the negotiation of research problems that are shared between educators and researchers.
DOI: 10.6084/m9.figshare.7149173.v2
title: Bidirectional Collaborations in an Intervention Randomized Controlled Trial Performed in the Swedish Early Childhood Education Context

description: Within the field of developmental science, there is a general agreement of the need to work together across academic disciplinary boundaries in order to advance the understandings of how to optimize child development and learning. However, experience also shows that such collaborations may be challenging. This paper reports on the experiences of bidirectional collaboration between researchers in a multidisciplinary research team and between researchers and stakeholders, in the first randomized controlled trial in Swedish preschool. The objective of the trial was to investigate the effects of two pedagogical learning strategies evaluating language, communication, attention, executive functions and early math. The interdisciplinary team includes researchers from early childhood education, linguistics, developmental psychology and cognitive neuro science. Educational researchers and theorists within the field of early childhood education in Sweden have during the last two decades mainly undertaken small-scale qualitative praxis-oriented and participative research. There is a widespread skepticism with regards to some of the core principles in controlled intervention methodologies, including a strong resistance towards individual testing of children. Consequently unanticipated disagreements and conflicts arose within the research team, as RCT methodology requires the measurement of effects pre and post the intervention. The aim of this article is to discuss the conditions for bidirectional collaboration both between researchers and stakeholders and between researchers in the research team. The findings illustrate strategies and negotiations that emerged in order to address ontological and epistemological controversies and disagreements. These include (a) the negotiation of research ethics, (b) making divergences visible and learning from each other, (c) using a multi-epistemological and methodological approach as a complement to the RCT design and (d) the negotiation of research problems that are shared between educators and researchers.
DOI: 10.7284/109440
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS1217 using a Raytheon 320 WAAS instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7149173.v1
title: Bidirectional collaborations in an intervention randomized controlled trial performed in the Swedish early childhood education context

description: Within the field of developmental science, there is a general agreement of the need to work together across academic disciplinary boundaries in order to advance the understandings of how to optimize child development and learning. However, experience also shows that such collaborations may be challenging. This paper reports on the experiences of bidirectional collaboration between researchers in a multidisciplinary research team and between researchers and stakeholders, in the first randomized controlled trial in Swedish preschool. The objective of the trial was to investigate the effects of two pedagogical learning strategies evaluating language, communication, attention, executive functions and early math. The interdisciplinary team includes researchers from early childhood education, linguistics, developmental psychology and cognitive neuro science. Educational researchers and theorists within the field of early childhood education in Sweden have during the last two decades mainly undertaken small-scale qualitative praxis-oriented and participative research. There is a widespread skepticism with regards to some of the core principles in controlled intervention methodologies, including a strong resistance towards individual testing of children. Consequently unanticipated disagreements and conflicts arose within the research team, as RCT methodology requires the measurement of effects pre and post the intervention. The aim of this article is to discuss the conditions for bidirectional collaboration both between researchers and stakeholders and between researchers in the research team. The findings illustrate strategies and negotiations that emerged in order to address ontological and epistemological controversies and disagreements. These include (a) the negotiation of research ethics, (b) making divergences visible and learning from each other, (c) using a multi-epistemological and methodological approach as a complement to the RCT design and (d) the negotiation of research problems that are shared between educators and researchers.
DOI: 10.6084/m9.figshare.7149167
title: Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, a close relative of the major human fungal pathogen Aspergillus fumigatus

description: <i>Aspergillus fischeri </i>is a close evolutionary relative of the major cause of invasive mold infections, <i>Aspergillus fumigatus</i>. In contrast to <i>A. fumigatus</i>, <i>A. fischeri </i>rarely causes invasive disease even though it is commonly found in diverse environments, including hospitals. Thus, it remains unclear why <i>A. fischeri </i>causes less human disease. To begin addressing this question, we characterized the pathogenic, genomic, and secondary metabolic similarities and differences between <i>A. fischeri </i>and <i>A. fumigatus</i>. We observed multiple differences between the two species for phenotypes related to pathogenesis, including that <i>A. fischeri </i>is less virulent than <i>A. fumigatus </i>in multiple murine models of invasive disease, exhibits slower growth in low oxygen environments, and is more sensitive to oxidative stress. In contrast, the genomic similarity between the two species is high; ~90% of the <i>A. fumigatus </i>proteome is conserved in <i>A. fischeri</i>, including 48 / 49 genes known to be involved in <i>A. fumigatus </i>virulence. However, only 10 / 33 <i>A. fumigatus </i>biosynthetic gene clusters (BGCs) likely involved in the production of secondary metabolites are conserved in <i>A. fischeri </i>and only 13 / 48 <i>A. fischeri </i>BGCs are conserved in <i>A. fumigatus</i>. Detailed chemical characterization of <i>A. fischeri </i>cultures grown on multiple substrates identified multiple secondary metabolites, including two new compounds and one never before isolated as a natural product. Interestingly, an <i>A. fischeri </i>deletion mutant of <i>laeA</i>, a master regulator of secondary metabolism, produced fewer secondary metabolites and in lower quantities, suggesting that regulation of secondary metabolism is at least partially conserved between the two species. These results suggest that the non-pathogenic <i>A. fischeri </i>possesses many of the genes important for <i>A. fumigatus </i>pathogenicity but is divergent with respect to its ability to thrive under host-relevant conditions and its secondary metabolism. <br>
DOI: 10.6084/m9.figshare.7149383.v2
title: Harnessing Transmedia Learning: How to Optimize Your Productivity with Learning Science, Media, and Technology

description: A long-time goal of educators, developers, researchers, and policy-makers alike is that ecosystems of learning applications will someday provide adaptive, personalized learning that is facilitated by data shared among technologies. However, until the technical promise is fully realized, learners are still largely on their own to make sense of increasing amounts of information from disparate, unconnected sources. Learners generally lack the strategic support to learn across devices and engage in connected learning anytime, anywhere, with anyone. We can disrupt this cycle when we use learning science strategies, tailored media choices, and our favorite technologies to incentivize rich, connected transmedia learning experiences. Applying learning science strategies for self-paced, transmedia learning “in the wild” can augment professional courses. Using several use cases as examples, this tutorial will demonstrate how learners can develop their own personalized transmedia learning frameworks (TLF) for self-directed learning when engaging with massively open online courses (MOOC), podcasts, social media, videos, and more.
DOI: 10.7284/109441
title: Gyrocompass data collected during research cruise WS1217 using a SGB Meridian instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/109448
title: INS (Inertial Navigation System) data collected during research cruise WS1217 using a Applanix POS/MV-320 V2 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7149167.v1
title: Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, the closest sequenced relative of the major human fungal pathogen Aspergillus fumigatus

description: <i>Aspergillus fumigatus </i>
DOI: 10.7284/109442
title: Radiometer data collected during research cruise WS1217 using a Eppley PSP instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7149134
title: Supplementary File 3 - gene counts and metadata.tar.gz

description: <b>Gene counts, gene metadata, and sample metadata from 6 dengue patients and 4 healthy controls.</b>
DOI: 10.6084/m9.figshare.7149104
title: Testing Fragility Data - ESEM

description: Dataset about code churn in a set of GitHub Android projects tested with GUI Automation Frameworks. Part of manuscript entitled "Scripted GUI Testing of Android Open-Source Apps: Evolution of Test Code and Fragility Causes".
DOI: 10.6084/m9.figshare.7149104.v1
title: Testing Fragility Data - ESEM

description: Dataset about code churn in a set of GitHub Android projects tested with GUI Automation Frameworks. Part of manuscript entitled "Scripted GUI Testing of Android Open-Source Apps: Evolution of Test Code and Fragility Causes".
DOI: 10.7284/109443
title: Radiometer data collected during research cruise WS1217 using a Eppley TUV instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/109447
title: Radiometer data collected during research cruise WS1217 using a Eppley PIR instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/109446
title: Rain Gauge data collected during research cruise WS1217 using a OSI ORG-815 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7148855
title: Indicators for monitoring maternal and neonatal quality care: a systematic review. Appendix A. Database of all indicators

description: This database contains the whole amount of indicators retrieved by systematic search as well as the total of indicators that were analyzed, including information on applied appraisal criteria.
DOI: 10.7284/109444
title: Water Temperature data collected during research cruise WS1217 using a Sea-Bird SBE-38 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/109445
title: TSG (Thermosalinograph) data collected during research cruise WS1217 using a Sea-Bird SBE-45 instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/109449
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS1218 using a Raytheon 300 WAAS instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7148855.v1
title: Indicators for monitoring maternal and neonatal quality care: a systematic review. Appendix A. Database of all indicators

description: This database contains the whole amount of indicators retrieved by systematic search as well as the total of indicators that were analyzed, including information on applied appraisal criteria.
DOI: 10.6084/m9.figshare.7148651
title: Dataset Dairy Heat Stress Gunn et al. 2018 PLOS ONE part 1

description: This dataset includes raw downscaled climate projections (1950-2100) for multiple locations across the U.S. with estimations of temperature humidity index, heat stress frequency, dry matter intake and milk production loss with or without heat abatement. This is the first set of data
DOI: 10.6084/m9.figshare.7148855.v2
title: Indicators for monitoring maternal and neonatal quality care: a systematic review. Appendix A. Database of all indicators

description: This database contains the whole amount of indicators retrieved by systematic search as well as the total of indicators that were analyzed, including information on applied appraisal criteria.
DOI: 10.7284/109450
title: GNSS (Global Navigation Satellite System) data collected during research cruise WS1218 using a Raytheon 320 WAAS instrument system onboard the platform RV F.G. Walton Smith

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7148081
title: 5-year dataset: single concept deviations

description: The single concept means and standard deviations of annual prevalence from the 5-year data set. File format: tab-delimited table; carriage return & newline terminated. Columns: concept id - Unique numeric code identifying the concept; mean - The mean of the annual prevalence (1.0 = 100%); std - The standard deviation of the annual prevalence. The rows are arranged in ascending order by concept id.
DOI: 10.6084/m9.figshare.7148084
title: Lifetime dataset: paired-concept deviations

description: The paired-concept means and standard deviations of annual co-occurrence rates from the lifetime data set. File format: tab-delimited table; carriage return & newline terminated. Columns: concept id1 - Unique numeric code identifying the first of the paired concepts; concept id2 - Unique numeric code identifying the second of the paired concepts; mean - The mean of the annual co-occurrence rates (1.0 = 100%); std - The standard deviation of the annual co-occurrence rates. The rows are arranged in ascending order by concept_id1, concept_id2.