cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6049331.v2
title: Triethylenetetramine/hydroxyethyl cellulose-functionalized graphene oxide monoliths for the removal of copper and arsenate ions

description: Nitrogen-doped graphene oxide monoliths (GOMs) were readily constructed by crosslinking graphene oxide (GO) using triethylenetetramine (TETA) and hydroxyethyl cellulose (HEC). The addition of HEC was beneficial to the formation of a network structure compared to that in the absence of HEC. The generated monoliths have shown various morphologies with different d spacing, layer thickness, and micropore size. Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses provided evidences for the formation of covalent C–N bonds and some nitrogen-containing heterocyclic composition inside the graphene oxide sheet, indicating that the interaction of GO with the amine crosslinker involved the crosslinking reaction between GO epoxides and amine groups. HEC was also involved in the N-doping reaction via the partial reduction of oxygen in HEC molecules. Analysis of X-ray diffraction (XRD) results indicated that the lattice distance between GO sheets increased after TETA/HEC crosslinking. Thermogravimetric analysis (TGA) confirmed the successful incorporation of crosslinker moieties on the surface of GO sheets. The fabricated GOMs could be used to efficiently adsorb metal ions and arsenate by the introduced polar functional groups on GO sheets and porous structures based on hydrogen bonds, whose morphologies and compositions were confirmed via XRD, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS).
DOI: 10.6084/m9.figshare.6049289
title: Supplementary Material for: LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

description: <b><i>Background/Aims:</i></b> In the process of bone development and remodeling, the vasculature is regarded as the communicative network between the bone and neighboring tissues. Recently, it has been reported that the processes of angiogenesis and osteogenesis are coupled temporally and spatially. However, few studies reported the relationship and relevant mechanism between osteoclastogenesis and vasculogenesis. <b><i>Methods:</i></b> Arraystar Mouse lncRNA microarray V3.0 was firstly used to analyze the differentially expressed lncRNA genes in osteoclast different stages during osteoclastogenesis. Cell counting kit 8 (CCK-8) analysis, quantitative real-time polymerase chain reaction (qRT-PCR) analysis, migration and tube formation assays were used to detect impact of osteoclast different stages on the proliferation, differentiation, migration and tube formation of endothelial progenitor cells (EPCs), respectively. Finally, transfection of AK131850 shRNA, miR-93-5p mimic and miR-93-5p inhibitor, qRT-PCR, western blotting, enzyme-linked immunosorbent assay (ELISA), fluorescence in situ hybridization (FISH) and luciferase reporter assay were carried out to dissect molecular mechanisms. <b><i>Results:</i></b> In this study, we found that newborn OCs (N-OC) and mature OCs (M-OC) during osteoclastogenesis significantly promoted proliferation, differentiation, migration and tube formation of endothelial progenitor cells (EPCs). Through lncRNA microarray and GO&pathway analysis, we found that AK131850 and co-expressed gene, vascular endothelial growth factor a (VEGFa), were significantly up-regulated in N-OC and M-OC. After inhibition of AK131850 the promoting effect of N-OC and M-OC on EPCs was reversed. Furthermore, we found that AK131850 directly competed miR-93-5p in N-OC and M-OC through sponge, thereby increasing VEGFa transcription, expression and secretion through derepressing of miR-93-5p on VEGFa. <b><i>Conclusion:</i></b> Our results provided the first finding that lncRNA-AK131850 sponged miR-93-5p in N-OC and M-OC during osteoclastogenesis to enhance the secretion of VEGFa, thus promoting vasculogenesis of EPCs.
DOI: 10.6084/m9.figshare.6049289.v1
title: Supplementary Material for: LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

description: <b><i>Background/Aims:</i></b> In the process of bone development and remodeling, the vasculature is regarded as the communicative network between the bone and neighboring tissues. Recently, it has been reported that the processes of angiogenesis and osteogenesis are coupled temporally and spatially. However, few studies reported the relationship and relevant mechanism between osteoclastogenesis and vasculogenesis. <b><i>Methods:</i></b> Arraystar Mouse lncRNA microarray V3.0 was firstly used to analyze the differentially expressed lncRNA genes in osteoclast different stages during osteoclastogenesis. Cell counting kit 8 (CCK-8) analysis, quantitative real-time polymerase chain reaction (qRT-PCR) analysis, migration and tube formation assays were used to detect impact of osteoclast different stages on the proliferation, differentiation, migration and tube formation of endothelial progenitor cells (EPCs), respectively. Finally, transfection of AK131850 shRNA, miR-93-5p mimic and miR-93-5p inhibitor, qRT-PCR, western blotting, enzyme-linked immunosorbent assay (ELISA), fluorescence in situ hybridization (FISH) and luciferase reporter assay were carried out to dissect molecular mechanisms. <b><i>Results:</i></b> In this study, we found that newborn OCs (N-OC) and mature OCs (M-OC) during osteoclastogenesis significantly promoted proliferation, differentiation, migration and tube formation of endothelial progenitor cells (EPCs). Through lncRNA microarray and GO&pathway analysis, we found that AK131850 and co-expressed gene, vascular endothelial growth factor a (VEGFa), were significantly up-regulated in N-OC and M-OC. After inhibition of AK131850 the promoting effect of N-OC and M-OC on EPCs was reversed. Furthermore, we found that AK131850 directly competed miR-93-5p in N-OC and M-OC through sponge, thereby increasing VEGFa transcription, expression and secretion through derepressing of miR-93-5p on VEGFa. <b><i>Conclusion:</i></b> Our results provided the first finding that lncRNA-AK131850 sponged miR-93-5p in N-OC and M-OC during osteoclastogenesis to enhance the secretion of VEGFa, thus promoting vasculogenesis of EPCs.
DOI: 10.6084/m9.figshare.6049280.v2
title: Partial melting of subducted Southern Qiangtang crust in northern Tibet: evidence from the geochemistry and geochronology of the Riwanchaka granodiorite porphyry in Central Qiangtang

description: This article presents new zircon U–Pb geochronology, Hf isotopic, and whole-rock major- and trace-element geochemical data that provide insights into the petrogenesis and tectonic history of the Riwanchaka granodiorite porphyries of Central Qiangtang, Tibet. Zircon U–Pb ages of 236–230 Ma indicate an early Late Triassic age of emplacement of the porphyries, and zircon Hf isotopic data yield εHf(t) values of – 7.0 to – 1.5 and ancient zircon Hf crustal model ages (T<sub>DM</sub><sup>C</sup>) of 1524–1220 Ma. The granodiorite porphyries are characterized by low K<sub>2</sub>O contents, high Mg# values, and relatively high Cr and Ni contents. They are classified as I-type calc-alkaline granite and are considered to have formed through the anatexis of ancient mafic crustal rocks with contributions from mantle-derived components. The geochemistry and isotopic compositions of all samples are similar to those of magmatic rocks that originated in the South Qiangtang crust. However, field observations indicate that the pluton intrudes the North Qiangtang crust, and we propose that the granodiorite porphyries were derived by partial melting of subducted continental crust of the South Qiangtang terrane. These new data have been integrated with data from previous studies to construct a new model of slab rollback during northward subduction of the Southern Qiangtang continental crust at <i>ca</i>. 245–226 Ma, thereby improving our understanding of magmatic processes involved in continental subduction in collision settings.
DOI: 10.6084/m9.figshare.6049280.v1
title: Partial melting of subducted Southern Qiangtang crust in northern Tibet: evidence from the geochemistry and geochronology of the Riwanchaka granodiorite porphyry in Central Qiangtang

description: This article presents new zircon U–Pb geochronology, Hf isotopic, and whole-rock major- and trace-element geochemical data that provide insights into the petrogenesis and tectonic history of the Riwanchaka granodiorite porphyries of Central Qiangtang, Tibet. Zircon U–Pb ages of 236–230 Ma indicate an early Late Triassic age of emplacement of the porphyries, and zircon Hf isotopic data yield εHf(t) values of – 7.0 to – 1.5 and ancient zircon Hf crustal model ages (T<sub>DM</sub><sup>C</sup>) of 1524–1220 Ma. The granodiorite porphyries are characterized by low K<sub>2</sub>O contents, high Mg# values, and relatively high Cr and Ni contents. They are classified as I-type calc-alkaline granite and are considered to have formed through the anatexis of ancient mafic crustal rocks with contributions from mantle-derived components. The geochemistry and isotopic compositions of all samples are similar to those of magmatic rocks that originated in the South Qiangtang crust. However, field observations indicate that the pluton intrudes the North Qiangtang crust, and we propose that the granodiorite porphyries were derived by partial melting of subducted continental crust of the South Qiangtang terrane. These new data have been integrated with data from previous studies to construct a new model of slab rollback during northward subduction of the Southern Qiangtang continental crust at <i>ca</i>. 245–226 Ma, thereby improving our understanding of magmatic processes involved in continental subduction in collision settings.
DOI: 10.6084/m9.figshare.6049208
title: Is the prickly pear a ‘Tzabar’? Diversity and conservation of Israel’s migrant species: Supplementary Material

description: Human-assisted biotic migration is a hallmark of the Anthropocene. Populations introduced outside their native ranges (‘migrant species’) have commonly been viewed as a threat to be addressed with lethal control programs. Israel has a long history of anthropogenic changes, and conservation has typically focused on ameliorating direct human impacts rather than eradicating migrant species. However, this may be changing with the growing influence of invasion biology worldwide. We conducted a review of the diversity, conservation status, and academic attitudes toward Israel’s migrant species (IMS). We identified 199 plants and animals from 85 families that have immigrated into Israel from across the globe, and 122 species from 64 families considered native to Israel that have emigrated to every bioregion and to two oceans, although few species have become cosmopolitan. The conservation status of most immigrant (84.9%) and emigrant (55.7%) species has not been assessed, and even the native ranges of eleven immigrants (5.5%) remains unknown. Of those assessed, 27% of immigrants are threatened or decreasing in their native ranges, and 62% of emigrants are globally decreasing or locally threatened and extinct. After accounting for local extinctions, immigration has increased Israel’s plant and vertebrate richness by 104 species. Israel’s immigrants are increasingly being viewed from an invasion biology perspective, with 76% of studies published in the past decade, reaching over a quarter of local conservation publications. Incorporating principles of compassionate conservation could help foster a more socially acceptable and morally grounded approach to the immigrant wildlife of the Middle East.
DOI: 10.6084/m9.figshare.6049208.v1
title: Is the prickly pear a ‘Tzabar’? Diversity and conservation of Israel’s migrant species: Supplementary Material

description: Human-assisted biotic migration is a hallmark of the Anthropocene. Populations introduced outside their native ranges (‘migrant species’) have commonly been viewed as a threat to be addressed with lethal control programs. Israel has a long history of anthropogenic changes, and conservation has typically focused on ameliorating direct human impacts rather than eradicating migrant species. However, this may be changing with the growing influence of invasion biology worldwide. We conducted a review of the diversity, conservation status, and academic attitudes toward Israel’s migrant species (IMS). We identified 199 plants and animals from 85 families that have immigrated into Israel from across the globe, and 122 species from 64 families considered native to Israel that have emigrated to every bioregion and to two oceans, although few species have become cosmopolitan. The conservation status of most immigrant (84.9%) and emigrant (55.7%) species has not been assessed, and even the native ranges of eleven immigrants (5.5%) remains unknown. Of those assessed, 27% of immigrants are threatened or decreasing in their native ranges, and 62% of emigrants are globally decreasing or locally threatened and extinct. After accounting for local extinctions, immigration has increased Israel’s plant and vertebrate richness by 104 species. Israel’s immigrants are increasingly being viewed from an invasion biology perspective, with 76% of studies published in the past decade, reaching over a quarter of local conservation publications. Incorporating principles of compassionate conservation could help foster a more socially acceptable and morally grounded approach to the immigrant wildlife of the Middle East.
DOI: 10.6084/m9.figshare.6049043
title: STRESS AND AUTONOMIC RESPONSE TO SLEEP DEPRIVATION IN MEDICAL RESIDENTS v2

description: El objetivo de este estudio fue evaluar el estrés producido por las guardias de 24 h en médicos residentes usando un enfoque multidimensional. Participaron dos grupos de médicos residentes que fueron seleccionados según el turno de trabajo: un grupo con privación de sueño (<i>n </i>= 42) que participó en una guardia activa de 24 h y otro grupo de contraste (<i>n </i>= 18) que participó en una jornada laboral normal sin privación de sueño. Todos completaron pre-post test durante un ciclo de 24 h realizadas las dos veces a las 8 h a.m. Las medidas incluyeron HRV, cortisol, rendimiento cognitivo y estado de ánimo transitorio. Los resultados mostraron que el efecto de la interacción grupo x fase fue significativa para todas las variables analizadas, indicando que los médicos en turno de guardia mostraban un deterioro significativo en todos los indicadores fisiológicos, de rendimiento y estado de ánimo en comparación con los participantes del grupo sin guardia. Estos resultados sugieren que es necesario revisar los sistemas de guardias médicas para reducir la carga de estrés que incide directamente en las condiciones de trabajo.
DOI: 10.6084/m9.figshare.6048674
title: Supplementary Material for: <b><i>Euodia daniellii</i></b> Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes

description: Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on palmitate-induced lipid accumulation and apoptosis in mouse primary hepatocytes. Cells were cultured in a control media or the same media containing 150 or 300 µmol/L of albumin-bound palmitate for 24 h. BO concentrations used were 0, 0.1, 0.2, or 0.5%. Palmitate induced lipid accumulation and mRNA expression of lipogenic genes such as <i>SREBP1c</i> and <i>SCD1</i>. However, BO prevented these changes. Furthermore, palmitate stimulated caspase-3 activity and decreased cell viability in the absence of BO. BO reduced palmitate-induced activation of caspase-3 and cell death in a dose-dependent manner. AMP-activated protein kinase inhibitors abolished the effects of BO. Furthermore, BO suppressed palmitate-induced c-Jun N-terminal kinase (JNK) phosphorylation through the 5' adenosine monophosphate-activated protein kinase (AMPK)-dependent pathway. In conclusion, BO attenuated palmitate-induced hepatic steatosis and apoptosis through AMPK-mediated suppression of JNK signaling. These data suggest that BO is an important determinant of saturated fatty acid-induced lipid accumulation and apoptosis, and may be an effective therapeutic strategy for treatment of obesity-mediated liver diseases.
DOI: 10.6084/m9.figshare.6047897
title: A systematic review of epidemiologic studies of styrene and cancer

description: Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies published through 13 November 2013. Since then, additional relevant research has been published. No review has included meta-analyses. The current systematic review considered research published through June 2017; included meta-analyses of the relationship between any exposure to styrene and cancers identified as being of concern, including non-Hodgkin lymphoma (NHL), leukemia and cancers of the esophagus, pancreas, lung and kidney; and evaluated several other forms of cancer. Meta-relative risks for all studies were 1.14 (95% confidence interval (CI), 0.91–1.43) for NHL, 1.00 (95% CI, 0.80–1.26) for multiple myeloma, 0.98 (95% CI, 0.87–1.09) for all leukemia, 1.03 (95% CI, 0.92–1.15) for esophageal cancer, 1.02 (95% CI, 0.93–1.12) for pancreatic cancer, 1.09 (95% CI, 0.95–1.24) for lung cancer and 1.10 (95% CI, 0.99–1.22) for kidney cancer. Individual studies provided little evidence of exposure-response or induction time trends. Limitations of the available research and of the meta-analyses included reliance in most studies on mortality data rather than on incidence data, lack of quantitative estimates of styrene exposure for individual subjects and lack of information on lifestyle factors. Consideration of all pertinent data, including substantial recent research, indicates that the epidemiologic evidence on the potential carcinogenicity of styrene is inconclusive and does not establish that styrene causes any form of cancer in humans.
DOI: 10.6084/m9.figshare.6047897.v1
title: A systematic review of epidemiologic studies of styrene and cancer

description: Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies published through 13 November 2013. Since then, additional relevant research has been published. No review has included meta-analyses. The current systematic review considered research published through June 2017; included meta-analyses of the relationship between any exposure to styrene and cancers identified as being of concern, including non-Hodgkin lymphoma (NHL), leukemia and cancers of the esophagus, pancreas, lung and kidney; and evaluated several other forms of cancer. Meta-relative risks for all studies were 1.14 (95% confidence interval (CI), 0.91–1.43) for NHL, 1.00 (95% CI, 0.80–1.26) for multiple myeloma, 0.98 (95% CI, 0.87–1.09) for all leukemia, 1.03 (95% CI, 0.92–1.15) for esophageal cancer, 1.02 (95% CI, 0.93–1.12) for pancreatic cancer, 1.09 (95% CI, 0.95–1.24) for lung cancer and 1.10 (95% CI, 0.99–1.22) for kidney cancer. Individual studies provided little evidence of exposure-response or induction time trends. Limitations of the available research and of the meta-analyses included reliance in most studies on mortality data rather than on incidence data, lack of quantitative estimates of styrene exposure for individual subjects and lack of information on lifestyle factors. Consideration of all pertinent data, including substantial recent research, indicates that the epidemiologic evidence on the potential carcinogenicity of styrene is inconclusive and does not establish that styrene causes any form of cancer in humans.
DOI: 10.6084/m9.figshare.6047183
title: Data for paper entitled "VST as a reliable academic placement tool despite cognate inflation effects"

description: These files bring all the data utilised for all analyses in the paper.
DOI: 10.6084/m9.figshare.6047183.v1
title: Data for VST AVT academic vocabulary investigation

description: These files bring all the data utilised for all analyses in the paper.
DOI: 10.6084/m9.figshare.6047063
title: Figure files from Effects of Lewis number on the statistics of the invariants of velocity gradient tensor and local flow topologies in turbulent premixed flames

description: Matlab fig files containing data used to produce figures
DOI: 10.6084/m9.figshare.6047063.v1
title: Figure files from Effects of Lewis number on the statistics of the invariants of velocity gradient tensor and local flow topologies in turbulent premixed flames

description: Matlab fig files containing data used to produce figures
DOI: 10.6084/m9.figshare.6047060
title: Matlab files from Effects of Lewis number on the statistics of the invariants of velocity gradient tensor and local flow topologies in turbulent premixed flames

description: Matlab codes used to produce the figures
DOI: 10.6084/m9.figshare.6046922
title: Iron overdose epidemiology, clinical features and iron concentration-effect relationships: the UK experience 2008–2017

description: <b>Background:</b> Iron poisoning is potentially serious, but mortality has fallen worldwide since implementation of pack size and packaging restrictions, and changes in iron use during pregnancy. The management of individual cases of overdose remains problematic due to uncertainty about indications for antidote. We examine the epidemiology of iron overdose in hospital cases referred to the UK National Poisons Information Service (NPIS) and evaluate the toxicokinetics of iron in patients ingesting only iron preparations. <b>Methods:</b> Anonymized hospital referral patient data from the NPIS database were collated for the period 1 January 2008 to 31 July 2017. Information was extracted, where recorded, on type of ingestion [iron alone (single), or combined with other agents (mixed)], reported dose, iron salt, timed iron concentrations and symptoms. In single-agent ingestions, the relationships between reported elemental iron dose, early concentrations (4–6 h), and symptoms were evaluated in teenagers and adults (≥13 years) and children (≤12 years) using standard statistical techniques (correlation and unpaired nonparametric comparisons). In those patients with sufficient sample points (three or more), a simple kinetic analysis was conducted. <b>Results:</b> Of 2708 patients with iron overdoses referred by UK hospitals for advice during the 9.7 years study period, 1839 were single-agent ingestions. There were two peaks in age incidence in single-agent exposures; 539/1839 (28.4%) were &lt;6 years (54.1% males) while 675/1839 (36.7%) were between 13 and 20 years (91% females), the latter a substantial excess over the proportion in the totality of hospital referrals to the NPIS in the same period (13–20 years: 23,776/144,268 16.5%; 67.5% female) (<i>p</i> p <b>Conclusion:</b> Single-agent iron exposures reported from UK hospitals were most common in children &lt;5 years and young people aged 13–20 years. Poisoning with organ failure was not identified and there were no fatalities. No correlations were observed between reported iron doses and early concentrations, or between iron concentrations and symptoms in this cohort of mild-to-moderate poisoning.