cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.25195865
title: Supplementary Material for: Transient Myopia and Ciliochoroidal Effusion following Influenza Vaccination

description: <b><i>Introduction:</i></b> The aim of the study was to report a case of ocular adverse events following influenza vaccination which involved bilateral myopic shift, ciliochoroidal effusion, and fine retinal folds in a middle-aged woman. <b><i>Case Presentation:</i></b> A 42-year-old female presented with sudden-onset painless binocular decreased distance vision. She had received a quadrivalent influenza vaccine (Influvac Tetra) injection 10 days prior, a few days after which she experienced blurred vision. Her initial uncorrected visual acuity and refraction were 20/200 and −3.00/−1.00 × 180 in the right eye, 20/100 and −3.00/−0.50 × 50 in the left eye. Intraocular pressure was within normal limits bilaterally. Anterior segment examination was significant for bilateral shallow anterior chambers (AC) and narrow iridocorneal angles with no cells or flare. Fundus examination was notable for bilateral fine chorioretinal folds radiating from the macula and bilateral low-lying choroidal effusion in the far periphery. Ultrasound biomicroscopy confirmed bilateral ciliochoroidal effusions, shallow AC, and anterior rotation of the ciliary bodies. The patient was started on oral and topical corticosteroids plus atropine and timolol eye drops after which prompt improvement was observed. Restoration of visual acuity and complete resolution of the symptoms without any further complication were observed after 2 weeks. <b><i>Conclusion:</i></b> The temporal association between the onset of the patient’s symptoms and influenza vaccination, in the absence of any pertinent medical conditions or medications, significantly implicates causality. Future research and case reports can help in corroborating this ocular adverse event attributed to influenza vaccination.
DOI: 10.6084/m9.figshare.14715176.v1
title: Additional file 9 of Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

description: Additional file 9: Table S8. CBS germline and somatic genetic mutations in the gastric TCGA cohort.
DOI: 10.6084/m9.figshare.7421717.v1
title: Additional file 2: of Genomic identification and functional analysis of essential genes in Caenorhabditis elegans

description: Identifications of essential genes. Including information about the allele name, the strain name, the genetic mapping zones [33], location, predicted gene, allele mutation, RNAi support, alleles support, and MMP support of the essential genes. The asterisk (*) signify a stop codon. (XLS 43 kb)
DOI: 10.6084/m9.figshare.20038895
title: A simple and sensitive method for determination of Norfloxacin in pharmaceutical preparations

description: In this approach, a new voltammetric method for determination of norfloxacin was proposed with high sensitivity and wider detection linear range. The used voltammetric sensor was fabricated simply by coating a layer of graphene oxide (GO) and Nafion composited film on glassy carbon electrode. The advantage of proposed method was sensitive electrochemical response for norfloxacin, which was attributed to the excellent electrical conductivity of GO and the accumulating function of Nafion under optimum experimental conditions, the present method revealed a good linear response for determination of norfloxacin in the range of 1×10<sup>-8</sup>mol/L-7×10<sup>-6</sup> mol/L with a detection limit of 5×10<sup>-9</sup> mol/L. The proposed method was successfully applied in the determination of norfloxacin in capsules with satisfactory results.
DOI: 10.6084/m9.figshare.14266956.v1
title: Additional file 2 of Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

description: Additional file 2. The results of HTS.
DOI: 10.6084/m9.figshare.20038884
title: Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

description: The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the in vitro release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (p&gt; 0.05). Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient.
DOI: 10.6084/m9.figshare.20038884.v1
title: Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

description: The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the in vitro release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (p&gt; 0.05). Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient.
DOI: 10.6084/m9.figshare.20038922.v1
title: Effects of maternal enflurane exposure on NR2B expression in the hippocampus of their offspring

description: This work aims to study the pathogenesis of learning and memory impairment in offspring rats resulting from maternal enflurane anesthesia by focusing on the expression of the N-methyl-d-aspartic acid receptor subunit 2B (NR2B) in the hippocampus of the offspring. Thirty female Sprague-Dawley rats were randomly divided into three groups: control (C group), 4 h enflurane exposure (E1 group), and 8 h enflurane exposure (E2 group) groups. Eight to ten days after the initiation of pregnancy, rats from the E1 and E2 groups were allowed to inhale 1.7% enflurane in 2 L/min oxygen for 4 h and 8 h, respectively. Rats from the C group were allowed to inhale 2 L/min of oxygen only. The Morris water maze was used to assay the learning and memory function of the offspring on postnatal days 20 and 30. RT-PCR and immunohistochemistry assays were then used to measure the mRNA levels and protein expression of NR2B, respectively. Relative to offspring rats from the C group, those from the E1 and E2 groups exhibited longer escape latencies, lesser number of crossings over the platform, and less time spent in the target quadrant in the spatial exploration test (P &lt; 0.05). In addition, the mRNA and protein expression levels of NR2B in the hippocampus of offspring rats in the E1 and E2 groups were down-regulated (P &lt; 0.05). No significant differences between the E1 and E2 groups were observed (P &gt; 0.05) in terms of mRNA levels and protein expression of NR2B. The cognitive function of the offspring is impaired when maternal rats are exposed to enflurane during early pregnancy. A possible mechanism of this effect is related to the down-regulation of NR2B expression.
DOI: 10.6084/m9.figshare.14796043.v1
title: Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports

description: Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN. Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects due to immunosuppressants. Both patients received intensive fresh FMT conducted through transendoscopic enteral tubing (TET) regularly for 6–7 months, and were followed up for a further 6 months. Partial clinical remission was achieved in both patients, evidenced by a decrease in the 24-h urinary protein (24-hUP) to less than half of baseline during FMT treatment or follow-up, along with increased serum albumin (sAlb) and stable kidney function. The gut microbiota of both patients was distorted with lower biodiversity and altered composition, which was reversed following FMT. Phylum <i>Proteobacteria</i> decreased while genus <i>Prevotella</i> increased during and after FMT. The intensive fresh FMT was well-tolerated, and no severe adverse events occurred. Preliminary evidence of the safety and efficacy of FMT for treating refractory IgAN may provide a new direction by which to decipher the pathogenesis of IgAN.
DOI: 10.6084/m9.figshare.20038953.v1
title: Effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites in rats

description: abstract The aim of this study was to evaluate the effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites. Rats were intragastrically administered caffeine (30 mg·kg-1, once per day), tea polyphenol (400 mg·kg-1, once per day) or daidzein (13.5 mg·kg-1, once per day) for 14 days, followed by an intragastric administration of lansoprazole (8 mg·kg-1) on the 15th day. The plasma concentrations of lansoprazole and its two primary metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Tea polyphenol significantly elevated the Area Under the Curve (AUC) of lansoprazole from 680.29 ± 285.99 to 949.76 ± 155.18 μg/L.h and reduced that of lansoprazole sulfone from 268.82 ± 82.37 to 177.72 ± 29.73 μg/L.h. Daidzein increased the AUC of lansoprazole from 680.29 ± 285.99 to 1130.44 ± 97.6 μg/L.h and decreased that of lansoprazole sulfone from 268.82 ± 82.37 to 116.23 ± 40.14 μg/L.h. The pharmacokinetics of 5-hydroxylansoprazole remained intact in the presence of tea polyphenol or daidzein. Caffeine did not affect the pharmacokinetics of lansoprazole and its metabolites. The results imply that tea polyphenol and daidzein may inhibit the in vivo metabolism of lansoprazole by suppressing CYP3A.
DOI: 10.6084/m9.figshare.14266965
title: Additional file 5 of Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

description: Additional file 5. The indel frequency of the off-target sites.
DOI: 10.6084/m9.figshare.20038922
title: Effects of maternal enflurane exposure on NR2B expression in the hippocampus of their offspring

description: This work aims to study the pathogenesis of learning and memory impairment in offspring rats resulting from maternal enflurane anesthesia by focusing on the expression of the N-methyl-d-aspartic acid receptor subunit 2B (NR2B) in the hippocampus of the offspring. Thirty female Sprague-Dawley rats were randomly divided into three groups: control (C group), 4 h enflurane exposure (E1 group), and 8 h enflurane exposure (E2 group) groups. Eight to ten days after the initiation of pregnancy, rats from the E1 and E2 groups were allowed to inhale 1.7% enflurane in 2 L/min oxygen for 4 h and 8 h, respectively. Rats from the C group were allowed to inhale 2 L/min of oxygen only. The Morris water maze was used to assay the learning and memory function of the offspring on postnatal days 20 and 30. RT-PCR and immunohistochemistry assays were then used to measure the mRNA levels and protein expression of NR2B, respectively. Relative to offspring rats from the C group, those from the E1 and E2 groups exhibited longer escape latencies, lesser number of crossings over the platform, and less time spent in the target quadrant in the spatial exploration test (P &lt; 0.05). In addition, the mRNA and protein expression levels of NR2B in the hippocampus of offspring rats in the E1 and E2 groups were down-regulated (P &lt; 0.05). No significant differences between the E1 and E2 groups were observed (P &gt; 0.05) in terms of mRNA levels and protein expression of NR2B. The cognitive function of the offspring is impaired when maternal rats are exposed to enflurane during early pregnancy. A possible mechanism of this effect is related to the down-regulation of NR2B expression.
DOI: 10.6084/m9.figshare.5883139
title: Zircon U–Pb ages and Hf isotopic compositions of two types of supracrustal rocks in the Northeastern Sulu UHP terrane: constraints on the surface boundary between South China and North China

description: There are voluminous ultrahigh pressure-related orthogneisses and minor metamorphic supracrustal rocks in the northeastern Sulu UHP terrane (NSL), East China. The tectonic affinities of the supracrustal rocks are crucial for unravelling the deep continental subduction processes and locating the tectonic suture between the South China (SCB) and North China (NCB) blocks. In this contribution, we report new zircon U–Pb ages and Hf isotope data for the supracrustal rocks and metagabbros in the Zeku region of the NSL. In the Zeku region, the supracrustal rocks are spatially associated with granitic gneisses, metagabbros, and eclogites. Detrital zircon U–Pb analyses yield ages between 3.39 and 0.65 Ga that cluster as three major age populations including (1) 2.15–1.68 Ga with two subpeaks at ~1.83 Ga and~1.97 Ga, (2) 2.45–2.15 Ga with a peak at ~2.37 Ga, and (3) 0.79–0.65 Ga. In addition, there is a small age population between 3.39 and 2.61 Ga. The youngest age population of 0.79–0.65 Ga indicates that the Zeku supracrustal rocks must have been deposited after 650 Ma rather than during the Palaeoproterozoic as previously thought. The 210–190 Ma metamorphic ages suggest that the Zeku rocks were affected by Triassic collision–subduction and exhumation. Most of the Archaean-Palaeoproterozoic zircons have negative ε<sub>Hf</sub>(t) values and two-stage Hf model ages concentrating at 2.4–3.4 Ga (peak at ~2.9 Ga), indicating that source rocks of these zircons were mainly derived from recycling of ancient crustal material. These ages, together with the Hf isotopic compositions and rock assemblages, indicate that the Zeku supracrustal rocks were mainly derived from the Precambrian basement rocks of the northern Yangzte Block and have a tectonic affinity to the SCB, rather than the NCB. Our results, together with previously published data, suggest that there are two types of supracrustal rocks with different zircon U–Pb ages and tectonic affinities in the NSL. On the basis of new data, we suggest that the surface boundary between the SCB and NCB in the Jiaodong Peninsula is a complicated tectonic mélange zone rather than a single fault.
DOI: 10.6084/m9.figshare.14266968
title: Additional file 6 of Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

description: Additional file 6. Statistical analysis and P values for each experiment.
DOI: 10.6084/m9.figshare.14796043
title: Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports

description: Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN. Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects due to immunosuppressants. Both patients received intensive fresh FMT conducted through transendoscopic enteral tubing (TET) regularly for 6–7 months, and were followed up for a further 6 months. Partial clinical remission was achieved in both patients, evidenced by a decrease in the 24-h urinary protein (24-hUP) to less than half of baseline during FMT treatment or follow-up, along with increased serum albumin (sAlb) and stable kidney function. The gut microbiota of both patients was distorted with lower biodiversity and altered composition, which was reversed following FMT. Phylum <i>Proteobacteria</i> decreased while genus <i>Prevotella</i> increased during and after FMT. The intensive fresh FMT was well-tolerated, and no severe adverse events occurred. Preliminary evidence of the safety and efficacy of FMT for treating refractory IgAN may provide a new direction by which to decipher the pathogenesis of IgAN.
DOI: 10.6084/m9.figshare.20038953
title: Effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites in rats

description: abstract The aim of this study was to evaluate the effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites. Rats were intragastrically administered caffeine (30 mg·kg-1, once per day), tea polyphenol (400 mg·kg-1, once per day) or daidzein (13.5 mg·kg-1, once per day) for 14 days, followed by an intragastric administration of lansoprazole (8 mg·kg-1) on the 15th day. The plasma concentrations of lansoprazole and its two primary metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Tea polyphenol significantly elevated the Area Under the Curve (AUC) of lansoprazole from 680.29 ± 285.99 to 949.76 ± 155.18 μg/L.h and reduced that of lansoprazole sulfone from 268.82 ± 82.37 to 177.72 ± 29.73 μg/L.h. Daidzein increased the AUC of lansoprazole from 680.29 ± 285.99 to 1130.44 ± 97.6 μg/L.h and decreased that of lansoprazole sulfone from 268.82 ± 82.37 to 116.23 ± 40.14 μg/L.h. The pharmacokinetics of 5-hydroxylansoprazole remained intact in the presence of tea polyphenol or daidzein. Caffeine did not affect the pharmacokinetics of lansoprazole and its metabolites. The results imply that tea polyphenol and daidzein may inhibit the in vivo metabolism of lansoprazole by suppressing CYP3A.
DOI: 10.6084/m9.figshare.14266965.v1
title: Additional file 5 of Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

description: Additional file 5. The indel frequency of the off-target sites.
DOI: 10.5281/zenodo.10634526
title: CMIF Gibran Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10636042
title: CMIF Ǧibrān Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10527378
title: CMIF Gibran Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10636001
title: CMIF Gibran Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10636005
title: CMIF Ǧibrān Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10636132
title: CMIF Ǧibrān Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.
DOI: 10.5281/zenodo.10638873
title: CMIF Ǧibrān Love Letters

description: CMIF dataset based on:

Bushrui, Suheil und Salma H. al-Kuzbari (Hrsg.): "Gibran Love Letters", One World, Oxford, 1995.

The CMIF dataset was created by students in the Eins@FU Lernwerkstatt: "Briefkorrespondenzen zwischen der arabischen Welt und Europa digital erforschen" at Freie Universität Berlin, using the CMIF Creator.