cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.4738021.v1
title: Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition

description: <b>Objective:</b> To evaluate the potential impact of adenomyosis on the pregnancy outcomes by retrospectively investigating adenomyosis-complicated pregnancy cases. <b>Methods:</b> We performed a retrospective case–control study. Forty-nine singleton pregnancy cases complicated with adenomyosis were included in this study. The controls (<i>n</i> = 245) were singleton pregnant women without adenomyosis and were frequency matched to adenomyosis cases by age, parity, and the need for assisted reproductive technology for this conception. The incidence of obstetrical complications and delivery and neonatal outcomes were examined. <b>Results:</b> Patients in the adenomyosis group were significantly more likely to have a second trimester miscarriage (12.2% versus 1.2%, odds ratio (OR): 11.2, 95% confidence interval (95% CI): 2.2–71.2), preeclampsia (18.3% versus 1.2%, OR: 21.0, 95% CI: 4.8–124.5), placental malposition (14.2% versus 3.2%, OR: 4.9, 95% CI: 1.4–16.3), and preterm delivery (24.4% versus 9.3%, OR: 3.1, 95% CI: 1.2–7.2), compared with the control group. <b>Conclusion:</b> Adenomyosis was associated not only with an increased incidence of preterm delivery, as previously reported, but also with an increased risk of second trimester miscarriage, preeclampsia, and placental malposition, which could lead to poor perinatal outcomes.
DOI: 10.6084/m9.figshare.4738027.v1
title: Quantum virial coefficients of molecular nitrogen

description: We report virial coefficients up to third order in density for molecular nitrogen, investigating 103 temperatures in the range (15 K, 3000 K). All calculations are based on an <i>ab initio</i>-based potential taken from the literature. Path-integral Monte Carlo (PIMC) is applied to account for nuclear quantum effects, and these results are compared to a more approximate but faster semiclassical treatment. Additionally, we examine a PIMC approach that employs semiclassical beads for the path-integral images, but find that it offers marginal advantage. A recently developed orientation sampling algorithm is used in conjunction with Mayer sampling to compute precise virial coefficients. We find that, within the precision of our calculations of the second-order coefficient (<i>B</i><sub>2</sub>), semiclassical methods are adequate for temperatures greater than 250 K, and are needed to correct classical behaviour for temperatures as high as 800 K. For the third-order coefficient (<i>B</i><sub>3</sub>), the semiclassical methods are adequate above 150 K, and are required up to the highest temperature examined (3000 K) in order to correct the classical treatment within the precision of the calculations. However, three-body contributions to the potential are much more significant than nuclear quantum effects for the evaluation of <i>B</i><sub>3</sub>.
DOI: 10.6084/m9.figshare.4738006
title: Simulation method for stochastic generation of domestic wastewater discharges and the effect of greywater reuse on gross solid transport

description: Together with significant water saving, due to lower wastewater discharges, greywater reuse (GWR) may also increase the impacts of faecal matter and other gross solids (GS) on sewer systems (sedimentation, blocking). Modelling and assessments of these effects require detailed descriptions of individual domestic wastewater streams. A novel stochastic methodology to generate such streams was developed and validated. The generator was developed while considering dependencies between in-house water-use events, and their varying degree of elasticity. These generated streams served as input to a sewer model, where scenarios of GWR were simulated and their effects on GS transport were examined. Extensive GWR decreases GS movement mostly in upstream links. Nevertheless, transient high flows, characterising these links, may move stationary GS and prevent blockages. The developed generator can be adopted to other sewer-related studies. Intelligent implementation of the results can assist in introducing GWR, or other water saving measures to the urban sector.
DOI: 10.6084/m9.figshare.4738003
title: Validation of 2D shock capturing flood models around a surcharging manhole

description: This work offers a detailed validation of finite volume (FV) flood models in the case where horizontal floodplain flow is affected by sewer surcharge flow via a manhole. The FV numerical solution of the 2D shallow water equations is considered based on two approximate Riemann solvers, HLLC and Roe, on both quadrilateral structured and triangular unstructured mesh-types. The models are validated against a high resolution experimental data-set obtained using a physical model of a sewer system linked to a floodplain via a manhole. It was verified that the sensitivity of the models is inversely proportional to the surcharged flow/surface inflow ratio, and therefore requires more calibration from the user especially when concerned with localised modelling of sewer-to-floodplain flow. Our findings provide novel evidence that shock capturing FV-based flood models are applicable to simulate localised sewer-to-floodplain flow interaction.
DOI: 10.6084/m9.figshare.4738006.v1
title: Simulation method for stochastic generation of domestic wastewater discharges and the effect of greywater reuse on gross solid transport

description: Together with significant water saving, due to lower wastewater discharges, greywater reuse (GWR) may also increase the impacts of faecal matter and other gross solids (GS) on sewer systems (sedimentation, blocking). Modelling and assessments of these effects require detailed descriptions of individual domestic wastewater streams. A novel stochastic methodology to generate such streams was developed and validated. The generator was developed while considering dependencies between in-house water-use events, and their varying degree of elasticity. These generated streams served as input to a sewer model, where scenarios of GWR were simulated and their effects on GS transport were examined. Extensive GWR decreases GS movement mostly in upstream links. Nevertheless, transient high flows, characterising these links, may move stationary GS and prevent blockages. The developed generator can be adopted to other sewer-related studies. Intelligent implementation of the results can assist in introducing GWR, or other water saving measures to the urban sector.
DOI: 10.6084/m9.figshare.4737991
title: Comparative transcriptome analysis between <i>Solanum lycopersicum</i> L. and <i>Lotus japonicus</i> L. during arbuscular mycorrhizal development

description: Arbuscular mycorrhizal (AM) fungi form symbiotic associations with diverse plant species. The AM fungi enhance mineral uptake from the soil, which benefits the growth of the host plants. Previous microarray and RNA-seq analyses have identified a large number of AM-responsive plant genes. However, little is known whether the gene expression profile of mycorrhiza is different among genetically distant plant species. The aim of this study was to assess the conservation and divergence of AM-responsive genes between two different hosts, <i>Solanum lycopersicum</i> L. and <i>Lotus japonicus</i> L., during AM development using RNA-seq data. In each host plant, gene expression was compared between AM roots and non-mycorrhizal (NM) roots. Potential orthologs of AM-responsible genes between <i>S. lycopersicum</i> and <i>L. japonicus</i> were identified with reciprocal BLAST searches. Only one quarter to one third of the AM-inducible genes in each plant species were co-upregulated in both species. The co-upregulated genes included those known to be essential for AM development and function. The co-upregulated genes exhibited a wide range of fold changes in the AM symbiosis, and the fold change value for individual co-upregulated genes was positively correlated between the two hosts. Most of the species-dependent upregulated genes exhibited low levels of induction. We also analyzed gene expression in AM fungi colonizing roots of <i>S. lycopersicum</i> and <i>L. japonicus</i>. Overall, the gene expression profiles of <i>Rhizophagus irregularis</i> were similar among the roots of the two different hosts, although hundreds of fungal genes were differentially expressed between the two hosts. In particular, genes related to the mitochondrial electron transport chain were highly expressed in AM fungi colonizing <i>L. japonicus</i> roots, indicating that adenosine triphosphate (ATP) production was enhanced in the <i>L. japonicus</i>–<i>R. irregularis</i> symbiosis. Overall, these results show that a certain proportion of AM-responsive genes is conserved across plant species. The species-dependent AM-responsive genes may be related to the physiological differences between AM and NM roots in each plant species.
DOI: 10.6084/m9.figshare.4738003.v1
title: Validation of 2D shock capturing flood models around a surcharging manhole

description: This work offers a detailed validation of finite volume (FV) flood models in the case where horizontal floodplain flow is affected by sewer surcharge flow via a manhole. The FV numerical solution of the 2D shallow water equations is considered based on two approximate Riemann solvers, HLLC and Roe, on both quadrilateral structured and triangular unstructured mesh-types. The models are validated against a high resolution experimental data-set obtained using a physical model of a sewer system linked to a floodplain via a manhole. It was verified that the sensitivity of the models is inversely proportional to the surcharged flow/surface inflow ratio, and therefore requires more calibration from the user especially when concerned with localised modelling of sewer-to-floodplain flow. Our findings provide novel evidence that shock capturing FV-based flood models are applicable to simulate localised sewer-to-floodplain flow interaction.
DOI: 10.6084/m9.figshare.4737976
title: Pulse profile and metal transfer in pulsed gas metal arc welding: droplet formation, detachment and velocity

description: The influence of current profile and pulse parameters on droplet formation and transfer was investigated. One profile has an exponential ramp up and down in the current pulse shape, while the second is nearly square shaped. High-speed photography, synchronised with a high-speed data acquisition system, was used to monitor the droplet formation and transfer. It was found that for long-tail current profile, most of droplet formation and detachment occurs before background current is reached. While, for the nearly square pulse, most of droplet formation and transfer occurs during background current, giving a stable and smooth metal transfer. The arc attachment position was found to vary for the different profiles. Droplet speed was measured, and it was found that it is proportional to the peak current and inversely proportional to background current. Dimensionless process parameters were defined and used to predict droplet speed using a neural networks algorithm.
DOI: 10.6084/m9.figshare.4737991.v1
title: Comparative transcriptome analysis between <i>Solanum lycopersicum</i> L. and <i>Lotus japonicus</i> L. during arbuscular mycorrhizal development

description: Arbuscular mycorrhizal (AM) fungi form symbiotic associations with diverse plant species. The AM fungi enhance mineral uptake from the soil, which benefits the growth of the host plants. Previous microarray and RNA-seq analyses have identified a large number of AM-responsive plant genes. However, little is known whether the gene expression profile of mycorrhiza is different among genetically distant plant species. The aim of this study was to assess the conservation and divergence of AM-responsive genes between two different hosts, <i>Solanum lycopersicum</i> L. and <i>Lotus japonicus</i> L., during AM development using RNA-seq data. In each host plant, gene expression was compared between AM roots and non-mycorrhizal (NM) roots. Potential orthologs of AM-responsible genes between <i>S. lycopersicum</i> and <i>L. japonicus</i> were identified with reciprocal BLAST searches. Only one quarter to one third of the AM-inducible genes in each plant species were co-upregulated in both species. The co-upregulated genes included those known to be essential for AM development and function. The co-upregulated genes exhibited a wide range of fold changes in the AM symbiosis, and the fold change value for individual co-upregulated genes was positively correlated between the two hosts. Most of the species-dependent upregulated genes exhibited low levels of induction. We also analyzed gene expression in AM fungi colonizing roots of <i>S. lycopersicum</i> and <i>L. japonicus</i>. Overall, the gene expression profiles of <i>Rhizophagus irregularis</i> were similar among the roots of the two different hosts, although hundreds of fungal genes were differentially expressed between the two hosts. In particular, genes related to the mitochondrial electron transport chain were highly expressed in AM fungi colonizing <i>L. japonicus</i> roots, indicating that adenosine triphosphate (ATP) production was enhanced in the <i>L. japonicus</i>–<i>R. irregularis</i> symbiosis. Overall, these results show that a certain proportion of AM-responsive genes is conserved across plant species. The species-dependent AM-responsive genes may be related to the physiological differences between AM and NM roots in each plant species.
DOI: 10.6084/m9.figshare.4737952
title: Commerce_draps_13e_siecle

description: Spatialité du commerce de la draperie au 13<sup>e</sup> s.
DOI: 10.6084/m9.figshare.4737976.v1
title: Pulse profile and metal transfer in pulsed gas metal arc welding: droplet formation, detachment and velocity

description: The influence of current profile and pulse parameters on droplet formation and transfer was investigated. One profile has an exponential ramp up and down in the current pulse shape, while the second is nearly square shaped. High-speed photography, synchronised with a high-speed data acquisition system, was used to monitor the droplet formation and transfer. It was found that for long-tail current profile, most of droplet formation and detachment occurs before background current is reached. While, for the nearly square pulse, most of droplet formation and transfer occurs during background current, giving a stable and smooth metal transfer. The arc attachment position was found to vary for the different profiles. Droplet speed was measured, and it was found that it is proportional to the peak current and inversely proportional to background current. Dimensionless process parameters were defined and used to predict droplet speed using a neural networks algorithm.
DOI: 10.6084/m9.figshare.4737937
title: Expression of cyclooxygenase-1 and cyclooxygenase-2, syndecan-1 and connective tissue growth factor in benign and malignant breast tissue from premenopausal women

description: Stromal factors have been identified as important for tumorigenesis and metastases of breast cancer. From 49 premenopausal women, samples were collected from benign or malignant tumors and the seemingly normal tissue adjacent to the tumor. The factors studied, with real-time polymerase chain reaction (PCR) and immunohistochemistry, were cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2), syndecan-1 (S-1) and connective tissue growth factor (CTGF). COX-1 and S-1 mRNA levels were higher in the malignant tumors than in normal and benign tissues. The COX-2 mRNA level was lower in the malignant tumor than in the normal tissue, while CTGF mRNA did not differ between the groups. COX-1 immunostaining was higher in stroma from malignant tumors than in benign tissues, whereas COX-2 immunostaining was higher in the malignant tissue. Glandular S-1 immunostaining was lower in malignant tumors compared to benign and normal tissues, and the opposite was found in stroma. Conclusively, mRNA levels of COX-1 and COX-2 were oppositely regulated, with COX-1 being increased in the malignant tumor while COX-2 was decreased. S-1 protein localization switched from glandular to stromal cells in malignant tissues. Thus, these markers are, in premenopausal women, localized and regulated differently in normal/benign breast tissue as compared to the malignant tumor.
DOI: 10.6084/m9.figshare.4737952.v1
title: Commerce_draps_13e_siecle

description: Spatialité du commerce de la draperie au 13<sup>e</sup> s.
DOI: 10.6084/m9.figshare.4737934
title: Gender-, age- and time-dependent dosing of growth hormone in adults – real-world data from a decade of clinical practice in Germany

description: We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003–2013) from 509 GH-treated patients (mean age: 48.9 years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0.25 [0.19] and males (0.24 [0.15]), but increased with treatment duration (at year 10, 0.55 [0.48] and 0.31 [0.09] in females and males, respectively), reflecting patient dose titration. GH dose increased more in females than males during treatment; this was statistically significant in years 2–6 (<i>p </i>&lt;<i> </i>0.05). Over the 10-year study period, a time trend of an overall estimated GH dose increase by 0.06 mg/day (females) and decrease by 0.07 mg/day (males) was shown; this interaction of gender and calendar year was significant (<i>p </i>&lt;<i> </i>0.0001). In both genders, overall GH dose decreased with increasing age (<i>p </i>&lt;<i> </i>0.0001). Our study confirms that females and younger patients require higher GH doses compared with males and older patients.
DOI: 10.6084/m9.figshare.4737937.v1
title: Expression of cyclooxygenase-1 and cyclooxygenase-2, syndecan-1 and connective tissue growth factor in benign and malignant breast tissue from premenopausal women

description: Stromal factors have been identified as important for tumorigenesis and metastases of breast cancer. From 49 premenopausal women, samples were collected from benign or malignant tumors and the seemingly normal tissue adjacent to the tumor. The factors studied, with real-time polymerase chain reaction (PCR) and immunohistochemistry, were cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2), syndecan-1 (S-1) and connective tissue growth factor (CTGF). COX-1 and S-1 mRNA levels were higher in the malignant tumors than in normal and benign tissues. The COX-2 mRNA level was lower in the malignant tumor than in the normal tissue, while CTGF mRNA did not differ between the groups. COX-1 immunostaining was higher in stroma from malignant tumors than in benign tissues, whereas COX-2 immunostaining was higher in the malignant tissue. Glandular S-1 immunostaining was lower in malignant tumors compared to benign and normal tissues, and the opposite was found in stroma. Conclusively, mRNA levels of COX-1 and COX-2 were oppositely regulated, with COX-1 being increased in the malignant tumor while COX-2 was decreased. S-1 protein localization switched from glandular to stromal cells in malignant tissues. Thus, these markers are, in premenopausal women, localized and regulated differently in normal/benign breast tissue as compared to the malignant tumor.
DOI: 10.6084/m9.figshare.4737934.v1
title: Gender-, age- and time-dependent dosing of growth hormone in adults – real-world data from a decade of clinical practice in Germany

description: We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003–2013) from 509 GH-treated patients (mean age: 48.9 years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0.25 [0.19] and males (0.24 [0.15]), but increased with treatment duration (at year 10, 0.55 [0.48] and 0.31 [0.09] in females and males, respectively), reflecting patient dose titration. GH dose increased more in females than males during treatment; this was statistically significant in years 2–6 (<i>p </i>&lt;<i> </i>0.05). Over the 10-year study period, a time trend of an overall estimated GH dose increase by 0.06 mg/day (females) and decrease by 0.07 mg/day (males) was shown; this interaction of gender and calendar year was significant (<i>p </i>&lt;<i> </i>0.0001). In both genders, overall GH dose decreased with increasing age (<i>p </i>&lt;<i> </i>0.0001). Our study confirms that females and younger patients require higher GH doses compared with males and older patients.
DOI: 10.6084/m9.figshare.4737913
title: Longitudinal evaluation of anhedonia as a mediator of fear of positive evaluation and other depressive symptoms

description: Fear of positive evaluation (FPE) is experiencing dread during real or potential praise. FPE is associated with social anxiety, but its relation to depressive symptoms is unclear. Anhedonia is a core symptom of depression related to symptoms of anxiety in cross-sectional research. The current study investigated the indirect effect of FPE on depressive symptoms via anhedonia over time. One-hundred ninety-six participants completed three waves of questionnaires over a total timespan of approximately four months via Amazon’s Mechanical Turk, including measures of FPE, depressive symptoms, and anticipatory and consummatory anhedonia. Findings indicated that anticipatory anhedonia at Time 2 mediated the relationship between FPE at Time 1 and depressive symptoms at Time 3. Consummatory anhedonia, however, did not. Each model was contextualised by accounting for prospective covarying relationships, such as depressive symptoms predicting the same symptoms at later waves. The constellation of findings is considered within a reward devaluation framework.
DOI: 10.6084/m9.figshare.4737913.v1
title: Longitudinal evaluation of anhedonia as a mediator of fear of positive evaluation and other depressive symptoms

description: Fear of positive evaluation (FPE) is experiencing dread during real or potential praise. FPE is associated with social anxiety, but its relation to depressive symptoms is unclear. Anhedonia is a core symptom of depression related to symptoms of anxiety in cross-sectional research. The current study investigated the indirect effect of FPE on depressive symptoms via anhedonia over time. One-hundred ninety-six participants completed three waves of questionnaires over a total timespan of approximately four months via Amazon’s Mechanical Turk, including measures of FPE, depressive symptoms, and anticipatory and consummatory anhedonia. Findings indicated that anticipatory anhedonia at Time 2 mediated the relationship between FPE at Time 1 and depressive symptoms at Time 3. Consummatory anhedonia, however, did not. Each model was contextualised by accounting for prospective covarying relationships, such as depressive symptoms predicting the same symptoms at later waves. The constellation of findings is considered within a reward devaluation framework.