cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2014.235
title: PLANNING TARGET VOLUME MARGIN DETERMINATION IN VMAT PROSTATE REGION USING CONE BEAM CT

description: In advanced radiation therapy technique, the determination of adequate clinical target volume (CTV) to planning target volume (PTV) margin is mandatory to reduce dose and side effect to normal tissues meanwhile increasing the dose to the tumor. The purpose of this study is to determine PTV margins for prostate region in volumetric modulated arc therapy (VMAT) based on inter and intra-fraction motion using cone beam computed tomography (CBCT) images. The 15 prostate patients who treated with TrueBeam linear accelerator were acquired weekly CBCT image before and after treatment and the CBCT images were registered to CT-simulator images with bony anatomy and natural calcium matching. The position deviations from standard image in X, Y and Z directions were recorded. The CTV to PTV margins were calculated using Van Herk’s equation according to random and systematic errors approach. The quality assurance of the image system showed that the mechanical test of couch movement was very accurate within 0.2 mm error. The image quality of CBCT with pelvis protocol was good enough for IGRT due to passing all of the Varian criteria needed. The software for image registration was also in good agreement between known shifted values and calculated from the program with the maximum error of 0.6 mm. For clinical application, patient setup variations as inter-fraction motion were more effect than patient movement during treatment as intra-fraction motion because of the patient fixation used and short time in VMAT treatment. The higher values in random error than systematic error were demonstrated because the high accuracy of machine itself with good IGRT system can reduce the systematic error; in contrast, the random error was unavoidable, especially from the effect of bladder-rectum filling. From 8 mm margin in our routine protocol at King Chulalongkorn Memorial Hospital. The calculated PTV margins in the lateral (X), longitudinal (Y), vertical (Z) directions reduce to 6.38, 5.24 and 6.33 mm, respectively. The Y direction is less effect from bladder and rectum filling and body change compared to other directions. From our calculated margins, it is possible to reduce the dose to bladder and rectum and improve the target coverage of prostate cancer patients who treated with VMAT technique.
DOI: 10.14457/cu.the.2014.236
title: The radiation dose to staff and patient from intraoperative O-ARM system in Percutaneous Transforaminal Lumbar Interbody Fusion (TLIF) surgery

description: The O-Arm system has the capability of combined two-dimensional fluoroscopy and three-dimensional computed tomography for intraoperative procedure. The increasing use of this system raises the concern of radiation exposure to staff and patients. The purpose of this study is to estimate the radiation dose delivered to staff and patient during Percutaneous TLIF surgery in 2D and 3D modes when using o-arm system. The data from one hundred patients underwent percutaneous TLIF surgery in 2D and 3D modes using O-Arm system were recorded from PACS (Picture Archiving and Communication System) and calculated for the patient radiation dose. For staff radiation dose, the scattered dose around the O-Arm gantry were measured using CT phantom to represent patient and scan with the maximum exposure parameters. The results showed that the average patient age was 59 (25-91) years. In 2D; the average exposure time was 15.09 (5.63-42.57) sec. The effective dose was 1.3 (0.34-4.63) mSv. In 3D; the average exposure time was 10.05 (7.80-15.64) sec. The effective dose was 10.38 (4.32-27.02) mSv. The number of scan was 2 times (53 cases), 3 times (37 cases) and 4 times (10 cases). The average effective dose from 2, 3 and 4 times scan were 8.14 mSv, 11.72 mSv and 16.97 mSv, respectively. In 2D, small size protocol was not selected. Medium size protocol was selected for 95 cases and the average effective dose was 1.27 (0.34-4.63) mSv. Large size protocol was selected for 5 cases and the average effective dose was 1.92 (1.4-3.15) mSv. In 3D, the ST3D protocol, small size protocol was not selected, medium size was selected for 63 cases and the average effective dose was 8.15 (4.32-19.59) mSv. The large size protocol was 34 cases and the average effective dose was 13.65 (10.79-21.61) mSv. In 3D, the HD3D protocol, the large size protocol selected was 3 cases and the average effective dose was 20.26 (13.51-27.02) mSv. The radiological technologist received scattered dose per month from patient in 2D and 3D of 49 and 32 μSv/month at 200 cm from patient. Other staff did not receive the scattered radiation as they were not in operating room during exposure. As the occupational dose limit is 4000 μSv/month, the radiologic technologist was safe working with O-Arm system. Cumulative dose to staff can be reduced by decreasing exposure time in 2D, reduce number of scan in 3D and stay behide the control panel during exposure. In addition the staff must wear the lead apron or using the protective barrier.
DOI: 10.14457/cu.the.2014.237
title: OPTIMIZATION OF RADIATION DOSE AND IMAGE QUALITY IN CHEST RADIOGRAPHY USING DIGITAL MOBILE X-RAY SYSTEM AT KING CHULALONGKORN MEMORIAL HOSPITAL

description: Digital Radiography (DR) has become an important imaging modality at Department of Radiology, King Chulalongkorn Memorial Hospital. In September 2013, the digital mobile x-ray system has been in service on the patient ward for patients who could not move to the Department of Radiology. Chest radiography is the most common examination performed on the patient ward. Some patient was exposed several times during treatment, result in increasing the radiation dose. As the DR produces less patient radiation dose than the CR and conventional radiograph, the exposure parameters use for DR must be determined. The purpose of this study is to optimize the radiation dose and image quality for digital mobile chest radiography. Lung Phantom was firstly used to study the appropriate exposure parameters to optimize the radiation dose at surface of the phantom and image quality based on the Commission of European Communities (CEC) and the qualitative noise evaluated by three observers. The exposure parameters obtained will be further used for patients. The proper exposure parameter for chest radiography was kVp 90 and mAs 0.63 for the patient chest thickness equal to or less than 23 cm. 50 patients were exposed by optimal parameters, then the patient dose had been calculated and the image quality has been assessed by three observers. The average patient dose was 0.076 mGy and the average of patient chest thickness was 19.70 cm. 88% of the images showed the image criteria score equal to or more than 3 where the acceptable score range from 3 to 6, 70% and 30% of the images showed the qualitative noise scores was 2 and 3 respectively where the acceptable score range from 2 to 3. The patient dose for routine chest study was 0.192 mGy. Therefore, the patient dose using optimal protocol was 60% less than routine study and also lower than the International Atomic Energy Agency dose reference level of 0.4 mGy for chest radiography.
DOI: 10.5281/zenodo.3340568
title: finals_2019_07_161

description: Log and boot files of game 161
DOI: 10.5281/zenodo.3340569
title: finals_2019_07_161

description: Log and boot files of game 161
DOI: 10.5281/zenodo.3340572
title: finals_2019_07_162

description: Log and boot files of game 162
DOI: 10.5281/zenodo.3340573
title: finals_2019_07_162

description: Log and boot files of game 162
DOI: 10.5281/zenodo.3340574
title: finals_2019_07_163

description: Log and boot files of game 163
DOI: 10.5281/zenodo.3340575
title: finals_2019_07_163

description: Log and boot files of game 163
DOI: 10.5281/zenodo.3340576
title: finals_2019_07_164

description: Log and boot files of game 164
DOI: 10.5281/zenodo.3340577
title: finals_2019_07_164

description: Log and boot files of game 164
DOI: 10.14457/cu.the.2014.238
title: Independent software for dose verification in cervical cancer brachytherapy

description: An independent software is used to verify the radiation dose of Oncentra software at point doses in high-dose–rate (HDR) brachytherapy. MuCheck is a software tool to validate the dose from the treatment planning calculation, performed by AAPM TG-43 algorithm with the same equation as Oncentra treatment planning system. The purpose of this study is to verify the dose at the reference points in HDR brachytherapy for the cervical cancer patients calculated by Oncentra treatment planning system with the MuCheck independent software. Source calibration was performed with the well chamber. The result showed 0.2% error from the source certification with less than 5% dose criteria. Furthermore, software verification was implemented with EBT2 film that showed -2.69±4.45% and -2.37±4.65% dose difference from Oncentra and MuCheck, respectively. According to the 253 cervical cancer treatment plans, the results revealed that the dose difference between Oncentra and MuCheck depended slightly on the applicator types. The MR compatible Flecther applicator remained the dose discrepancy that was 0.18±0.91%, -0.24±0.97%, 0.49±0.52%, 0.44±0.86% at point A, point B, bladder and rectum, respectively. The needles combined with Utrecht applicator resulted in 0.34±0.58%, 0.37±0.25%, 0.62±0.54%, 0.75±0.91% of the dose difference at point A, point B, bladder and rectum, respectively. The vaginal cylinder applicator showed the dose difference that was 0.52±0.76%, 0.25±0.51%, 0.55±0.43%, 0.58±0.44% at point A, point B, bladder and rectum, respectively. The needles presented the highest discrepancy due to more complex plans. Another factor for the dose varying was the position of the mark points. Additionally for 253 cases, the % frequency that obtained the dose difference within 1% were 81.82%, 87.74%, 90.12%, and 82.21% at point A, point B, bladder and rectum, respectively. Point A showed lower %pass at 1% compared with point B because it located in the high dose gradient point. The maximum percent dose difference was within 3% according to AAPM TG-59. Thus, MuCheck is an accuracy and precision independent approach, which is suitable to perform the patient specific quality assurance for HDR brachytherapy promptly and expediently.
DOI: 10.14457/cu.the.2014.239
title: STANDARDIZED UPTAKE VALUE OF 99mTc-SESTAMIBI IN MYOCARDIAL PERFUSION SPECT/CT

description: The standardized uptake value (SUV) of 99mTc SESTAMIBI in myocardial perfusion imaging is the measured activity normalized for surface area and injected dose. As a reference, if the dose were uniformly distributed over the entire body, the value everywhere would be one. The purpose of this study is to determine the standardized uptake value in myocardial perfusion imaging patients using quantitative SPECT/ CT protocol. The materials in this study include SPECT/CT system, 99mTc SESTAMIBI, one hollow cylindrical phantom, two anthropomorphic phantoms with inserts, twenty patients with normal myocardial perfusion scan and twenty-seven abnormal patients who underwent coronary angiogram. Conversion Factor and recovery coefficient were calculated using the above phantoms and then applied to the patients. The average conversion factor and recovery coefficient were 4875 CPM/MBq and 0.565 respectively. In using the e-soft reconstruction algorithm, the SUV for mean and SD in normal myocardial perfusion scan for rest and stress studies were 8.15±1.21 and 8.00±1.5 respectively. Using Image J software method, the average SUV for three vessels of the heart, LAD, LCX and RCA, in normal myocardial perfusion imaging were 7.70±1.2, 8.15±1.1, 7.61±1.3 in rest scan and 7.67±1.2, 8.04±1.5, 7.56±1.2 in stress scan. By comparing the two methods with T-test, the SUV for normal patients were not significantly different. For abnormal scan, z scoring method is used to define the cut off score between normal SUV and abnormal SUV from image J segmentation method. Coronary angiography result was used as a gold standard to define diagnostic index. The score result on each segment of left ventricle had been compared with MPI retrospective report. The results showed that SUV had higher negative predictive value for eliminating perfusion defects. Specificity of 74%, sensitivity of 58% and accuracy of 67% of SUV study for the heart were higher than conventional myocardial perfusion imaging (51%,52%,51%), respectively. The severity of defect can be observed by looking at the negative score level. The benefit of this study is to obtain absolute quantification for myocardium perfusion measurement in SUV values.
DOI: 10.14457/cu.the.2014.240
title: Surface dose comparison between Acuros XB and Anisotropic Analytical Algorithmfor breast cancer radiotherapy

description: A new algorithm for photon dose calculation, Acuros XB, has been recently introduced in the new version of Eclipse treatment planning, it employs a sophisticated Linear Boltzmann transport equation (LBTE) to account for the effects of heterogeneities in patient dose calculation. The purpose of this research is to compare the surface dose between AAA and the new algorithm Acuros XB in breast cancer radiotherapy techniques. The study was performed for surface dose verification in the homogenous solid water phantom and non-homogeneous CIRS thorax phantom. Moreover, the surface doses of 12 breast conserving surgery cases were investigated with 8 treatment planning techniques, i.e. open field, standard wedged tangent (SWT), electronic compensator (E Comp), field-in-field (FF), tangential intensity modulated radiation therapy (T IMRT), coplanar intensity modulated radiation therapy (CP IMRT), non-coplanar intensity modulated radiation therapy (NCP IMRT) and volumetric modulated arc therapy (VMAT) in Eclipse treatment planning system (TPS) using AAA and Acuros XB. The surface point doses were recorded at tip, medial and lateral sides of the breast at the surface, 4mm, 6mm depth and compared in both algorithms. The surface dose verification in homogeneous phantom showed AAA and Acuros XB calculation were higher than film measurement of 33.32% and 12.31%, respectively. The verification in CIRS phantom illustrated that AAA and Acuros XB were 28.96% and 14.31%, respectively, underestimated dose than film measurement at the surface. For the patient analysis, the tip of the breast showed the highest differences for surface between two algorithms, especially CP IMRT and VMAT techniques. The surface dose differences of the lateral side was much higher than the medial side of the breast. At the deeper depth start from 6mm, both calculation algorithms showed the good agreement approximately 6% for all techniques, which agreed with Akino et al study. It is concluded that the treatment planning system cannot give the accurate dose for surface dose calculation, as verified with the EBT2 film on homogeneous slab phantom and non-homogeneous CIRS thorax IMRT phantom. Acuros XB contributes very high dose differences to the AAA at the surface, especially CP IMRT and VMAT, but comparable at the deeper depth starting from 6 mm. The surface dose for breast radiotherapy depends on the geometry of the structure and treatment techniques used.
DOI: 10.14457/cu.the.2014.241
title: Safety of Phenylephrine in Antihypotensive Treatment during Spinal Anesthesia for Cesarean Section

description: Objective: In Thailand, hypotension after spinal anesthesia for cesarean section is routinely treated by ephedrine. As incidence of fetal acidosis reportedly increases resulting from placental transfer, phenylephrine, an α1 agonist with less lipid solubility, becomes an alternative. However, the potential development of serious bradycardia is a concern. The objectives were to investigate the incidence of serious bradycardia, identify associated risk factors and other side effects of phenylephrine. Materials & Methods: This descriptive cross-sectional study was conducted from July 1, 2014 to March 15, 2015 on 509 parturients undergoing cesarean section under spinal anesthesia. Predelivery hypotension was treated by intravenous (IV) phenylephrine 100 mcg and pretherapeutic heart rate (pHR) was recorded. If serious bradycardia (HR &lt; 60 bpm and hypotension or HR &lt; 45 bpm) developed, atropine 0.6 mg was administered IV. Data were analyzed using multivariable logistic regression. Results & Discussion: Incidence of serious bradycardia was 11% (95% CI: 8.0-14.0). A one bpm increment increase in pHR reduced this incidence by 4% (adjusted OR: 0.96; 95% CI: 0.94-0.98, p&lt;0.001; AuROC: 0.76). As compared to a pHR &gt; 80 bpm, a pHR of 61-80 and ≤ 60 bpm increased the risk by 3.55 times and 12.81 times, respectively. Other risk factors were height, baseline DBP, and anesthetic level at 1st minute. Benign and temporary abnormal ECG readings were also found. Conclusion: Phenylephrine is an alternative vasopressor for antihypotensive treatment during spinal anesthesia for cesarean section. It may induce benign bradycardia which spontaneously recover. The incidence of therapeutic required bradycardia was higher in the parturient who had lower heart rate. However, this can be effectively managed by intravenous atropine. No abnormality of APGAR Scores which is associated with phenylephrine was shown.
DOI: 10.14457/cu.the.2014.242
title: Distribution of porcine circovirus type 2 (PCV2) antigens and pathological changes in testes, seminal vesicles, and prepuce of culled boars

description: Porcine circovirus type 2 (PCV2) is a swine pathogen causing porcine circovirus associated disease (PCVAD). The interaction between PCV2 and boar’s reproductive organs is of interest. It has been shown that PCV2 could be shedded via semen and the virus might use the boar’s reproductive organs as reservoir. Moreover, PCV2 could induce in reproductive organ is not known. In the present study, we determined the prevalence of PCV2 in boar’s reproductive organs. The antigen distribution in boar’s reproductive organs was also characterized. Testes, seminal vesicles, and prepuces were collected from 59 culled. Thirteen boars contained PCV2 DNA in the reproductive organs. PCV2 antigen distribution study revealed that the prevalence of PCV2 antigen was highest in the testis (76.9%), followed by the prepuce (38.5%), and then the seminal vesicle (30.8%). The testis showed significantly higher prevalence than the seminal vesicle (p &lt; 0.05). Various cell types, including Leydig cells, Sertoli cells, and germinal epithelial cells, showed positive signal of PCV2 antigen. However, these findings were not related with testicular degeneration. In the seminal vesicles, the antigen was found only in the glandular epithelial cells. In the prepuces, the antigen was detected in lymphocytes in the mucosal lymphoid follicles with lymphoid depletion. This is the first time that PCV2 antigen was identified in boar’s prepuces. Our study provided knowledge of PCV2 antigen distribution in boar’s reproductive organs indicating an impact of these organs for PCV2 spreading via semen.
DOI: 10.14457/cu.the.2014.243
title: COMPARATIVE STUDY ON ANTI-INFLAMMATORY PROPOTIES OFPCSO-524 AND SPECIFIC COX 2 NON-STEROIDALANTI-INFLAMMATORY DRUG (NSAID) IN DOG UNDERGOING MEDIAL PATELLAR LUXATION REPAIR.

description: Thirty client-owned Pomeranians, 1 - 7 year- old with medial patellar luxation grade 3 and no other diseases are enrolled in this experiment. All dogs received physical examination, orthopedic examination, clinical scoring system, force platform gait analysis and blood collection by the same veterinarian before surgery and at day 1, 5 and 14 after surgery. After surgery of correction of medial patellar luxation, they are divided into 3 groups by random sampling. The first group received only Firocoxib (5 mg/kg once daily). The second group received only PCSO-524 (10 mg/kg, twice daily). The third group received Firocoxib (5 mg/kg, once daily) combining with PCSO-524 (10 mg/kg, twice daily). Treatment was finished at the end of the 2nd week. IL-1β and IL-6 concentration in serum are determined by commercially available canine ELISA kit. In conclusion, PCSO-524 can improve clinical signs in Pomeranian dogs after surgical correction of medial patellar luxation. The dogs in all groups of treatments had weight-bearing scores and gait data similar to standard score of normal dog in day 14 after surgery. However, PCSO-524 alone could not reduce blood level of inflammatory mediators when compared with NSAID, indicating that PCSO-524 did not have anti-inflammatory effect as good as NSAID in case of post-operative care of patellar luxation’s surgery.
DOI: 10.14457/cu.the.2014.244
title: Reproductive Performances of Three Group Breeders of Replacement Gilts for Backyard Pig Farms in Thailand

description: Most of pig production in countryside of Thailand is backyard farm. Almost all of farmers manage it as the second source of their income. As a result, the production costs are quite low. The production in each farm has been emanated from insufficient costs to cover all management. Especially, an essential basis of reproductive management; for instance, almost all of owners have been using female fatteners as replacement gilts. Both factors contribute to low litter size. Therefore, all of the problems are conduced to this study. The replacement gilts were classified by mating strategies and were divided into 3 groups: group 1 (Gr1: 30 crossbred gilts; produced by crossbred boar (Landrace (L) x Yorkshire (Y): LY 50/50) and crossbred sow (LY 50/50)), group 2 (Gr2: 30 crossbred gilts; produced by purebred boar (Yorkshire) and purebred sow (Landrace)) and group 3 (Gr3: 30 hybrid gilts; (Landrace x Yorkshire x Duroc: 25/25/50)). The average age at first observed estrus of replacement gilts in all 3 groups was 229.94±15.77 days of age and the gilts were mated at age 253.84±15.62 days of age. An average age at first farrowing was 368±15.57 days of age. There was not different between each group. Body weight at first service was 121.06±9.16 kg. In addition, backfat thickness at first observed estrus and at first service was approximately 13 and 18 mm respectively, in all groups. There was no significant difference (P&gt;0.05) in all traits. TB, BA and mean birth weight of piglets in group 2 was the highest mean that equaled 12.73±3.13, 11.63±2.79 (piglets/litter) and 1.56±1.22 kg, respectively. There were significantly different between each of three groups (P&lt;0.05) in average numbers of piglets in both total and alive sections. There was no significant difference (P&gt;0.05) in average birth weight between group 1 and 2. According to the results of this observation, mean of weaning weight of piglets in group 1 was the highest (6.83±0.93 kg). There was significant difference (P&lt;0.05) between group 1 and the other two groups. Percentage of pre-weaning mortality in group 1 was the lowest (2.90%). There was significantly different (P&lt;0.05) of this amount between group 1 and group 2. The result of health condition screening of replacement found that three kinds of parasite eggs were found in feces samples including Strongyle, Ascaris suum and Trichuris suis. The results of serum antibodies to PRRS and PPV were reported that all serum samples were negative for PRRSV antibody; PPV antibody present in all serum samples. The average of feces P4 metabolite concentration on day 1 was the lowest and the highest on day 12 after standing heat. In conclusion, overall results suggested that the crossbred (LY) provides a higher reproductive performance than fattener female breeder. The appropriate model of gilt replacement can be successfully developed in order to produce the good production in backyard farm.