cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31253405.v1
title: Fall Risk Assessments for Individuals with Visual Impairment: A Scoping Review of Questionnaire-Based Tools

description: Individuals with visual impairment are at high risk of falls due to sensory, functional, and environmental challenges. Existing fall risk assessment tools rarely address vision-related challenges. This scoping review identified and summarized questionnaire-based tools used to assess fall risk in individuals with visual impairment to map the literature, highlight research gaps, and inform preventive strategies. Adhering to Joanna Briggs Institute Scoping Review methodology and PRISMA-ScR guidelines, 19 studies met inclusion criteria, yielding 11 vision-specific questionnaires. Findings highlight gaps in evidence and indicate the need for future research examining measurement properties and developing approaches.
DOI: 10.6084/m9.figshare.31055371
title: Formononetin-derived quantum dots suppress colon cancer growth by triggering mitochondrial apoptosis

description: Formononetin (FMN) is an extracted component of traditional Chinese medicine with anticancer effects, but its poor water solubility and low bioavailability have limited further research and application. Therefore, based on FMN that is the natural antitumor agent, we synthesized a formononetin quantum dots (FMNQDs) for colon cancer therapy, which has the advantages of outstanding water solubility, homogeneous particle size (2.03 ± 1.0 nm), exceptional stability and good intracellular fluorescence imaging effect. The results show that FMNQD exhibits good antitumor activity by inducing mitochondrial-mediated apoptosis, characterized by elevated intracellular reactive oxygen species (ROS) levels, decreased mitochondrial membrane potential (MMP), and modulated expression of Bax and Bcl-2. In <i>vivo</i> validation confirmed FMNQD’s significant tumor growth inhibition. The tumor inhibition rate in the 8 mg/kg dose group was as high as 60.06 ± 6.22%. Moreover, blood biochemical analysis suggested a favorable safety profile. This study establishes FMNQDs as a potential therapeutic agent for colon cancer, providing preclinical evidence to support further development of formononetin-based nanomedicines.
DOI: 10.6084/m9.figshare.31055371.v1
title: Formononetin-derived quantum dots suppress colon cancer growth by triggering mitochondrial apoptosis

description: Formononetin (FMN) is an extracted component of traditional Chinese medicine with anticancer effects, but its poor water solubility and low bioavailability have limited further research and application. Therefore, based on FMN that is the natural antitumor agent, we synthesized a formononetin quantum dots (FMNQDs) for colon cancer therapy, which has the advantages of outstanding water solubility, homogeneous particle size (2.03 ± 1.0 nm), exceptional stability and good intracellular fluorescence imaging effect. The results show that FMNQD exhibits good antitumor activity by inducing mitochondrial-mediated apoptosis, characterized by elevated intracellular reactive oxygen species (ROS) levels, decreased mitochondrial membrane potential (MMP), and modulated expression of Bax and Bcl-2. In <i>vivo</i> validation confirmed FMNQD’s significant tumor growth inhibition. The tumor inhibition rate in the 8 mg/kg dose group was as high as 60.06 ± 6.22%. Moreover, blood biochemical analysis suggested a favorable safety profile. This study establishes FMNQDs as a potential therapeutic agent for colon cancer, providing preclinical evidence to support further development of formononetin-based nanomedicines.
DOI: 10.6084/m9.figshare.31057327
title: Hydrogels for acne treatment: a systematic review and meta-analysis of clinical trials

description: Hydrogels are three-dimensional, water-rich polymer networks that enhance drug delivery, hydration, and tolerability in topical acne therapy. This systematic review and meta-analysis evaluated the efficacy and safety of hydrogel-based formulations for acne treatment. Systematic search of PubMed, Embase, Scopus, and Cochrane Library (inception – September 2025) was performed following PRISMA guidelines. Eligible clinical trials assessed hydrogel-based therapies for acne reporting quantitative lesion outcomes. Random-effects meta-analysis was conducted using standardized mean difference (SMD) as the effect estimate. Risk of bias (RoB 2, ROBINS-I), heterogeneity (I<sup>2</sup>), and publication bias (funnel plot, Egger’s test) were assessed. (PROSPERO: CRD420251140597). Thirteen studies (n = 3,654) met inclusion criteria, with seven (n = 2,986) included in the meta-analysis. Hydrogel-based formulations demonstrated favorable outcomes over comparators. Eight studies reported significant improvements in acne severity or lesion reduction (p &lt; 0.05), while five showed non-significant but positive trends. Pooled meta-analysis confirmed significant benefit for hydrogels (SMD =  −0.47, 95% CI − 0.78 to −0.16; p = 0.003). Despite high heterogeneity among meta-analyzed studies (I<sup>2</sup> = 86%), all showed consistent direction of effect favoring hydrogels. No serious events reported. Topical hydrogels effectively reduce acne lesions with excellent safety and tolerability. Larger, well-designed RCTs are warranted to confirm long-term outcomes.
DOI: 10.6084/m9.figshare.31057327.v1
title: Hydrogels for acne treatment: a systematic review and meta-analysis of clinical trials

description: Hydrogels are three-dimensional, water-rich polymer networks that enhance drug delivery, hydration, and tolerability in topical acne therapy. This systematic review and meta-analysis evaluated the efficacy and safety of hydrogel-based formulations for acne treatment. Systematic search of PubMed, Embase, Scopus, and Cochrane Library (inception – September 2025) was performed following PRISMA guidelines. Eligible clinical trials assessed hydrogel-based therapies for acne reporting quantitative lesion outcomes. Random-effects meta-analysis was conducted using standardized mean difference (SMD) as the effect estimate. Risk of bias (RoB 2, ROBINS-I), heterogeneity (I<sup>2</sup>), and publication bias (funnel plot, Egger’s test) were assessed. (PROSPERO: CRD420251140597). Thirteen studies (n = 3,654) met inclusion criteria, with seven (n = 2,986) included in the meta-analysis. Hydrogel-based formulations demonstrated favorable outcomes over comparators. Eight studies reported significant improvements in acne severity or lesion reduction (p &lt; 0.05), while five showed non-significant but positive trends. Pooled meta-analysis confirmed significant benefit for hydrogels (SMD =  −0.47, 95% CI − 0.78 to −0.16; p = 0.003). Despite high heterogeneity among meta-analyzed studies (I<sup>2</sup> = 86%), all showed consistent direction of effect favoring hydrogels. No serious events reported. Topical hydrogels effectively reduce acne lesions with excellent safety and tolerability. Larger, well-designed RCTs are warranted to confirm long-term outcomes.
DOI: 10.6084/m9.figshare.31113511
title: Anti-apoptotic effects of ruthenium nanozyme-augmented adipose stem cells accelerate cutaneous wound healing

description: The failure of conventional therapies for diabetic wounds, including those relying solely on stem cells or antioxidants, stems from an inability to simultaneously overcome the hostile microenvironment characterized by chronic inflammation, excessive apoptosis, and impaired regeneration. We developed a novel combinatorial platform, Ru@SVF, by integrating ruthenium nanozymes (RuNC) with a stromal vascular fraction gel (SVF-GEL). This design moves beyond simple material addition, aiming for synergy: RuNC provides potent reactive oxygen species (ROS) scavenging and anti-apoptotic signaling, while SVF-GEL ensures sustained release of pro-regenerative growth factors (VEGF, EGF, bFGF). After thorough physicochemical characterization and biocompatibility assessment, its mechanism and efficacy were evaluated in vitro and in a diabetic rat model. Ru@SVF exhibited excellent biocompatibility and superior functionality. In vitro, it not only robustly suppressed inflammation and mitochondrial apoptosis (via Bax/Bcl-2/Caspase-3,9 regulation) in HUVECs but also enhanced the secretion of key growth factors. In vivo, Ru@SVF treatment led to significantly accelerated wound closure, which was accompanied by reduced apoptosis, diminished inflammatory infiltration, and promoted angiogenesis, outperforming treatments with either RuNC or SVF-gel alone. The Ru@SVF composite represents a significant advance by synergistically integrating catalytic nano-therapy with functional cell delivery. Its capacity to concurrently resolve inflammation, prevent apoptosis, and activate reparative signaling within a single platform addresses the multifaceted pathology of diabetic wounds more effectively than single-target strategies, offering a novel and promising therapeutic paradigm.
DOI: 10.6084/m9.figshare.31113511.v1
title: Anti-apoptotic effects of ruthenium nanozyme-augmented adipose stem cells accelerate cutaneous wound healing

description: The failure of conventional therapies for diabetic wounds, including those relying solely on stem cells or antioxidants, stems from an inability to simultaneously overcome the hostile microenvironment characterized by chronic inflammation, excessive apoptosis, and impaired regeneration. We developed a novel combinatorial platform, Ru@SVF, by integrating ruthenium nanozymes (RuNC) with a stromal vascular fraction gel (SVF-GEL). This design moves beyond simple material addition, aiming for synergy: RuNC provides potent reactive oxygen species (ROS) scavenging and anti-apoptotic signaling, while SVF-GEL ensures sustained release of pro-regenerative growth factors (VEGF, EGF, bFGF). After thorough physicochemical characterization and biocompatibility assessment, its mechanism and efficacy were evaluated in vitro and in a diabetic rat model. Ru@SVF exhibited excellent biocompatibility and superior functionality. In vitro, it not only robustly suppressed inflammation and mitochondrial apoptosis (via Bax/Bcl-2/Caspase-3,9 regulation) in HUVECs but also enhanced the secretion of key growth factors. In vivo, Ru@SVF treatment led to significantly accelerated wound closure, which was accompanied by reduced apoptosis, diminished inflammatory infiltration, and promoted angiogenesis, outperforming treatments with either RuNC or SVF-gel alone. The Ru@SVF composite represents a significant advance by synergistically integrating catalytic nano-therapy with functional cell delivery. Its capacity to concurrently resolve inflammation, prevent apoptosis, and activate reparative signaling within a single platform addresses the multifaceted pathology of diabetic wounds more effectively than single-target strategies, offering a novel and promising therapeutic paradigm.
DOI: 10.5281/zenodo.18484468
title: A Latin American Initiative to Understand Disorders of Gut-Brain Interaction in Schoolchildren and Adolescents with Autism DataSet
DOI: 10.6084/m9.figshare.28765613
title: Optical multi-beam steering and communication using integrated acousto-optics arrays

description: Source data and processing code for plotting figures for paper entitled "Optical multi-beam steering and communication using integrated acousto-optics arrays"
DOI: 10.15468/dl.gc8gha
title: Occurrence Download

description: A dataset containing 328986 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Digitalis purpurea L.)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Living Specimen, Machine Observation, Literature Occurrence)",
 "Geometry POLYGON((-180 -90,180 -90,180 90,-180 90,-180 -90))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1945"
 ]
}

 The dataset includes 328986 records from 1529 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0014275-250402121839773/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zcr5jq
title: Occurrence Download

description: A dataset containing 5390 species occurrences available in GBIF matching the query:
{
 "Geometry" : [
 "POLYGON((-97.5 17.7,-97.3 17.7,-97.3 18,-97.5 18,-97.5 17.7))"
 ]
}

 The dataset includes 5390 records from 122 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0290774-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4dp3tm
title: Occurrence Download

description: A dataset containing 30752 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "TaxonKey is Ginkgo biloba L."
 ]
}

 The dataset includes 30752 records from 101 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0011938-210819072339941/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vwukxv
title: Occurrence Download

description: A dataset containing 331 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phylloscartes lanyoni G.R.Graves, 1988"
 ]
}

 The dataset includes 331 records from 10 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010844-190320150433242/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jdbh4v
title: Occurrence Download

description: A dataset containing 576410 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-180 0,180 0,180 90,-180 90,-180 0))",
 "OccurrenceStatus is Present",
 "TaxonKey is Dactylorhiza Neck. ex Nevski",
 "Year 1950-2021"
 ]
}

 The dataset includes 576410 records from 617 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0299889-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8x2jp3
title: Occurrence Download

description: A dataset containing 54235 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aedes aegypti (Linnaeus, 1762)"
 ]
}

 The dataset includes 54235 records from 62 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0257359-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wv1tqj
title: Occurrence Download

description: A dataset containing 35510 species occurrences available in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "BasisOfRecord is Literature Occurrence",
 "BasisOfRecord is Specimen",
 "BasisOfRecord is Human Observation",
 "BasisOfRecord is Observation"
 ]
 },
 "HasCoordinate is true",
 "TaxonKey is Sematophyllaceae",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 35510 records from 142 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0010845-180131172636756/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.86wdtz
title: Occurrence Download

description: A dataset containing 13 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-83.1775547999999958 42.3514842000000016, -83.1775547999999958 42.3525965999999983, -83.1775547999999958 42.3541857399999984, -83.1775547999999958 42.3552186800000001, -83.1775547999999958 42.3568872800000022, -83.1775547999999958 42.3581585900000022, -83.1775547999999958 42.3594299000000021, -83.1759669599999967 42.3594299000000021, -83.1742204199999975 42.3594299000000021, -83.1731883700000054 42.3594299000000021, -83.1716006000000050 42.3594299000000021, -83.1700922200000008 42.3594299000000021, -83.1676311800000008 42.3594299000000021, -83.1659640200000041 42.3594299000000021, -83.1636617599999965 42.3594299000000021, -83.1615976599999982 42.3594299000000021, -83.1604068299999994 42.3594299000000021, -83.1588984499999953 42.3594299000000021, -83.1578664000000032 42.3594299000000021, -83.1563580199999990 42.3594299000000021, -83.1551671999999940 42.3594299000000021, -83.1529443200000031 42.3594299000000021, -83.1513565500000027 42.3594299000000021, -83.1503244999999964 42.3594299000000021, -83.1484985000000023 42.3594299000000021, -83.1484985000000023 42.3584764200000023, -83.1484985000000023 42.3568078200000002, -83.1484985000000023 42.3558543299999997, -83.1484985000000023 42.3544241099999965, -83.1484985000000023 42.3532322499999978, -83.1484985000000023 42.3514842000000016, -83.1496893900000060 42.3514842000000016, -83.1510389999999973 42.3514842000000016, -83.1523092099999985 42.3514842000000016, -83.1542145399999981 42.3514842000000016, -83.1558023000000048 42.3514842000000016, -83.1579457899999994 42.3514842000000016, -83.1600098899999978 42.3514842000000016, -83.1617564400000049 42.3514842000000016, -83.1635823700000003 42.3514842000000016, -83.1646144200000066 42.3514842000000016, -83.1662021900000070 42.3514842000000016, -83.1685838399999966 42.3514842000000016, -83.1707273300000054 42.3514842000000016, -83.1723944799999941 42.3514842000000016, -83.1737440899999996 42.3514842000000016, -83.1757288000000017 42.3514842000000016, -83.1775547999999958 42.3514842000000016))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 13 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0090894-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.thjegp
title: Occurrence Download

description: A dataset containing 136 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-94.5234413000000018 39.0847721000000021, -94.5234413000000018 39.0873062200000021, -94.5234413000000018 39.0923744700000029, -94.5234413000000018 39.0960604599999968, -94.5234413000000018 39.1011287099999976, -94.5234413000000018 39.1055058299999985, -94.5234413000000018 39.1085007000000004, -94.5197613299999944 39.1085007000000004, -94.5151613700000013 39.1085007000000004, -94.5096414199999941 39.1085007000000004, -94.5059614500000009 39.1085007000000004, -94.5004414999999938 39.1085007000000004, -94.5004414999999938 39.1059665800000005, -94.5004414999999938 39.1011287099999976, -94.5004414999999938 39.0981338400000027, -94.5004414999999938 39.0935263399999968, -94.5004414999999938 39.0891492200000030, -94.5004414999999938 39.0847721000000021, -94.5064214500000048 39.0847721000000021, -94.5107914099999959 39.0847721000000021, -94.5165413600000051 39.0847721000000021, -94.5234413000000018 39.0847721000000021))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 136 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0094502-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.m3zbna
title: Occurrence Download

description: A dataset containing 1513456 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Psittacula krameri (Scopoli, 1769)"
 ]
}

 The dataset includes 1513456 records from 1209 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066007-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qmvuza
title: Occurrence Download

description: A dataset containing 30 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-80.3503340000000037 40.9799122000000011, -80.3503340000000037 40.9833437899999993, -80.3503340000000037 40.9855400200000020, -80.3503340000000037 40.9874617099999980, -80.3503340000000037 40.9904815100000022, -80.3503340000000037 40.9936385800000025, -80.3503340000000037 40.9958347999999972, -80.3486808899999971 40.9958347999999972, -80.3457879500000018 40.9958347999999972, -80.3435838099999984 40.9958347999999972, -80.3402775899999995 40.9958347999999972, -80.3365581000000049 40.9958347999999972, -80.3365581000000049 40.9926777299999969, -80.3365581000000049 40.9903442499999997, -80.3365581000000049 40.9867753899999983, -80.3365581000000049 40.9841673800000024, -80.3365581000000049 40.9811475699999974, -80.3365581000000049 40.9799122000000011, -80.3411041500000067 40.9799122000000011, -80.3431705299999948 40.9799122000000011, -80.3457879500000018 40.9799122000000011, -80.3481298600000002 40.9799122000000011, -80.3503340000000037 40.9799122000000011))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 30 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0097498-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.83p5gn
title: Occurrence Download

description: A dataset containing 857 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Draba pauciflora R.Br."
 ]
}

 The dataset includes 857 records from 38 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0156925-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gu76yr
title: Occurrence Download

description: A dataset containing 61 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON ((-94.6503378000000026 39.1154738999999978, -94.6503378000000026 39.1198394899999968, -94.6503378000000026 39.1238082100000000, -94.6503378000000026 39.1263878800000029, -94.6503378000000026 39.1303565999999989, -94.6503378000000026 39.1353174999999993, -94.6455649600000015 39.1353174999999993, -94.6395983500000000 39.1353174999999993, -94.6336317300000047 39.1353174999999993, -94.6300517600000006 39.1353174999999993, -94.6274662299999960 39.1353174999999993, -94.6226929399999932 39.1353174999999993, -94.6197096300000027 39.1353174999999993, -94.6163289999999932 39.1353174999999993, -94.6163289999999932 39.1317456499999992, -94.6163289999999932 39.1295628600000001, -94.6163289999999932 39.1265863200000013, -94.6163289999999932 39.1240066499999983, -94.6163289999999932 39.1198394899999968, -94.6163289999999932 39.1154738999999978, -94.6205051799999950 39.1154738999999978, -94.6232896000000068 39.1154738999999978, -94.6274662299999960 39.1154738999999978, -94.6304495400000008 39.1154738999999978, -94.6344272799999970 39.1154738999999978, -94.6405927800000057 39.1154738999999978, -94.6433772000000033 39.1154738999999978, -94.6473549399999996 39.1154738999999978, -94.6503378000000026 39.1154738999999978))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1932",
 "BasisOfRecord is one of (Human Observation, Living Specimen, Observation, Specimen, Machine Observation)"
 ]
}

 The dataset includes 61 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0094514-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.