cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17639/nott.7213
title: Single cell metabolic profiling of macrophages using 3D OrbiSIMS: correlations with phenotype

description: ABSTRACT: Macrophages are important immune cells that respond to environmental cues acquiring a range of activation status represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their spectrum. Characterizing the metabolic signature (metabolic profiling) of different macrophage subsets is a powerful tool to understand the response of the human immune system to different stimuli. Here, the recently developed 3D OrbiSIMS instrument is applied to yield useful insight into the metabolome from individual cells after in-vitro differentiation of macrophages into naïve, M1 and M2 phenotypes using different cytokines. This analysis strategy not only requires more than 6 orders of magnitude less sample than traditional mass spectrometry approaches, but also allows the study of cell-to-cell variance. Characteristic metabolites in macrophage subsets are identified using a targeted lipid and data driven multivariate approached highlighting amino acids and other small molecules. The diamino acids alanylsparagine and lipid sphingomyelin, SM(d18/16:0) are uniquely found in M1 macrophages while pyridine and pyrimidine are observed at increased intensity in M2 macrophages, findings which link to known biological pathways. The first demonstration of this capability illustrates the great potential of direct cell analysis for in-situ metabolite profiling with the 3D OrbiSIMS to probe functional phenotype at the single cell level using molecular signatures and to understand the response of the human body to implanted devices and immune diseases.
DOI: 10.17639/nott.7237
title: Badger Liver Elemental Concentrations

description: This dataset contains the concentrations of 30 elements found in the livers of 448 badgers collected in the English Midlands in 2016 - 2017. All concentrations are in mg / kg dry weight.
DOI: 10.17639/nott.7245
title: Electron Transport in n-Type InSe Van Der Waals Crystals with Co Impurities

description: Electron Transport in n-Type InSe Van Der Waals Crystals with Co Impurities
DOI: 10.17639/nott.7194
title: Raw Data corresponding to the work: "Merging bioderived and artificial materials to create new composites for the bioprinting of bioelectronic cardio-3D-cellular constructs"

description: This data set corresponds to the work entitled "Merging bioderived and artificial materials to create new composites for the bioprinting of bioelectronic cardio-3D-cellular constructs" and contains documents regarding the material characterisation, bioprinting optimisation and cell characterisation
DOI: 10.17639/nott.7212
title: Raw data for new compounds described in the paper "Synthesis of New Morphinan Opioids by TBADT-Catalyzed Photochemical Functionalization at the Carbon Skeleton"

description: Raw data for new compounds described in the paper "Synthesis of New Morphinan Opioids by TBADT-Catalyzed Photochemical Functionalization at the Carbon Skeleton"
DOI: 10.17639/nott.7203
title: Biofilm disruption activity of absorbent sustained action alginate and iodine combined wound dressings
title: Proof of concept project "Biofilm disruption activity of absorbent sustained action alginate and iodine combined wound dressings" (03PoC20-150) data

description: Test new wound dressing formulations against clinically relevant polymicrobial biofilms
DOI: 10.17639/nott.7211
title: Does sex of the jockey influence racehorse physiology and performance

description: Two datasets to accompany PLoSone article
DOI: 10.17639/nott.6545
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 42882

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 42882 (III) Source: VDRC Name: Dscam4 (2) Full name: Down syndrome cell adhesion molecule 4 Also known as: Annotation symbol: CG42330 FlyBase ID: FBgn0263219 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.7239
title: Further evidence for the role of temporal contiguity as a determinant of overshadowing

description: Three experiments explored whether weakening temporal contiguity between auditory cues and an outcome attenuated cue-competition in an avoidance learning task with human participants. Overall, with strong temporal contiguity between auditory cues and the outcome during training (the offset of the predictive auditory signals concurred with the onset of the outcome), the target cue trained as part of a compound yielded less avoidance behaviour than the control cue trained alone, an instance of overshadowing. However, weakening temporal contiguity during training (inserting a 5s trace) attenuated overshadowing, resulting in similar avoidance behaviour in response to the control and the target cues. Moreover, as predicted by a recent modification of Pearce’s configural theory (Pearce, 1987; see Herrera et al., 2022), temporal contiguity was critical in determining cue competition.
DOI: 10.17639/nott.6548
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 19230

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 19230 (III) Source: VDRC Name: Dys Full name: Dystrophin Also known as: det, Dystrophin, DLP2, DLP1, DLP3 Annotation symbol: CG34157 FlyBase ID: FBgn0260003 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6544
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 25366

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 25366 (III) Source: VDRC Name: Dscam4 (1) Full name: Down syndrome cell adhesion molecule 4 Also known as: Annotation symbol: CG42330 FlyBase ID: FBgn0263219 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.6420
title: An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 31640R1

description: This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
description: Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 31640R1 (III) Source: NIG Name: CG34380 (1) Full name: smoke alarm Also known as: smal Annotation symbol: CG34380 FlyBase ID: FBgn0085409 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
DOI: 10.17639/nott.7180
title: Raw data of reactor performance testing using vermiculite-based composite

description: A small chamber was built for materials test/analysis. Composite (vermiculite with MgSO4 and CaCl2) was selected for the reactor performance test. Contains raw data of the air conditions at the inlet and outlet of the reactor.
DOI: 10.17639/nott.7250
title: TrustScapes transcripts: exploring young people's trust-related concerns about co-created online resources to promote mental health literacy

description: The objective of the present study was to explore young people’s trust-related concerns about and recommendations for the co-created mental health website by using TrustScapes. The findings was used to improve the trustworthiness of the website and to inform future creators of online mental health resources.
DOI: 10.17639/nott.7158
title: Evaluating the work-life balance framework, with insights from Denmark
title: Literature sources.

description: Sources on work-life balance in Denmark. Produced from a project funded by the British Academy/Leverhulme Trust Small Research Grant (reference SRG19\190498), supported by the Department for Business, Energy and Industrial Strategy.
DOI: 10.17639/nott.7246
title: Health motivations and perceived barriers are determinants of self-care behaviour for the prevention of hypertension in a Malaysian community
title: Hypertension self-care behaviour

description: Self-care behaviour is fundamental in preventing hypertension in the general population. According to the Health Belief Model, health beliefs and perceptions influence the success in adopting disease prevention strategies. This was a cross-sectional study conducted between 12 June 2020 to 26 July 2021. An online survey was administered via email and social media to Malaysians in the Selangor and Kuala Lumpur communities. Respondents were over 18 years old, without a formal diagnosis of hypertension. The survey evaluated hypertension knowledge, Health Belief Model constructs, self-care behaviour frequency, and motivators and barriers to self-care behaviour.
DOI: 10.17639/nott.7173
title: Raw data for new compounds described in the paper "Gold(I)-Catalyzed Nucleophilic Allylation of Azinium Ions with Allylboronates"

description: Raw data for new compounds described in the paper "Gold(I)-Catalyzed Nucleophilic Allylation of Azinium Ions with Allylboronates"
DOI: 10.17639/nott.7238
title: Data for "Optimal sampling of dynamical large deviations in two dimensions via tensor networks" by L. Causer, M.C. Banuls and J.P. Garrahan

description: Contains the data used in the figures in the paper "Optimal sampling of dynamical large deviations in two dimensions via tensor networks" by L. Causer, M.C. Banuls and J.P. Garrahan. Also contains movies which show trajectories from the monte carlo algorithm created in these works.
DOI: 10.17639/nott.7191
title: Metabolomics & gene expression microarray data

description: Metabolomic data (IDEOM file) based on liquid-chromatography mass spectrometry for two brain tumour cell lines (U373 and KNS42), under two cell culture conditions in vitro: lipoprotein-replete (indicated as 'FBS'); lipoprotein-deplete (indicated as 'LCS'). Gene expression microarray data (CEL files) based on liquid-chromatography mass spectrometry for two brain tumour cell lines (U373 and KNS42), under two cell culture conditions in vitro: lipoprotein-replete (indicated as 'FBS'); lipoprotein-deplete (indicated as 'LCS').
DOI: 10.17639/nott.7202
title: Molecular nanomachines for photoactivated biofilm disruption
title: Seed funding project "Molecular nanomachines for photoactivated biofilm disruption" (01Seed20-08) data

description: Data embargoed until publication of associated journal article
description: Study on the impact of molecular nanodrills on bacterial viability and biofilm formation
DOI: 10.17639/nott.7241
title: Electric field responsive nanotransducers for glioblastoma

description: Data set associated with the following manuscript - Electric field responsive nanotransducers for glioblastoma. Accepted for publication in Bioelectronic medicine.
DOI: 10.17639/nott.7236
title: RRI in industry case studies

description: This is the output of a meta-synthesis of published Responsible Research and Innovation in industry case studies. The file contains two tabs: publications - this lists publications identified as containing RRI industry case studies and whether they were selected for inclusion in an analysis of outcomes, and associated metadata. case studies - this lists the organisation case studies identified as a result of the literature review, and associated metadata.
DOI: 10.17639/nott.7230
title: Golden ratio - planetary orbits Python source code

description: Python code that simulates the planetary orbits showing the Golden Ratio nature of their conjunctions.
DOI: 10.17639/nott.7171
title: Spatial contiguity determines overshadowing between global-shape representations and stimulus-response associations in human navigation

description: Recent failures to observe cue competition in different preparations, together with the long-standing debate about competition phenomena in the spatial learning literature, have casted doubts on their generality. A recent study (Herrera et al., in press) suggested that strong goal-landmark contiguity might be a critical factor for competition to occur in human spatial navigation. This study aimed to extend those findings and evaluate the effect of goal-landmark contiguity together with variations in the starting-point locations, and the length of training trials. Participants were requested to find an invisible goal (a Wi-Fi hotspot) in a virtual T-Maze. Each group was trained with a landmark placed at different distances from the goal (Proximal, Middle, Distal and Control - no landmark). During test, participants were instructed to look the Wi-Fi signal outside of the arena, to assess if the landmark impaired or not its global representation. In Experiment 1, participants were released from a fixed location over 15 training trials, in Experiment 2 participants were released from multiple locations, and in Experiment 3 participants were released from a fixed arm but received 3 trials only. Overshadowing was found under strong contiguity (Proximal Group), but only when participants were consistently released from the same location and received extended training (Experiment 1), and no other cue competition effects were found across experiments. These results add further support to the increasing literature that shows strong contiguity is a key determinant of overshadowing in human spatial navigation, and we characterise the conditions under which this happens.
DOI: 10.17639/nott.7198
title: Data files for: Graphene FETs with high and low mobilities have universal temperature-dependent properties

description: Data files for: "Graphene FETs with high and low mobilities have universal temperature-dependent properties" research paper submitted in May 2022
DOI: 10.17639/nott.7195
title: Dataset of Ethnographic Study of Cooking - Interactions of CPGs and other items

description: Dataset of a fieldwork study on cooking investigating the preparation of familiar and unfamiliar meals. The .xlsx file contains annotations of the interaction between people and consumer packaged goods and other items involved in cooking.
DOI: 10.17639/nott.7183
title: Social overshadowing: revisiting cue-competition in social interactions

description: Understanding how we use the information surrounding us to extract patterns and guide our behavior has been of major interest in psychological research, in both social and nonsocial contexts. On the one hand, associative learning psychology has largely documented how human and nonhuman animals learn through trials to respond to rewarding stimuli, and avoid those that are not. On the other hand, researchers in social psychology have extensively investigated how our perception of and interactions with others dynamically evolve as a result of acquiring information about them. The present research adopts a domain-general approach of learning and explores whether the principles underlying associative learning also govern learning in social contexts. In particular, we examined whether overshadowing, a well-established cue-competition phenomenon, impacts learning of the cooperative behaviors of unfamiliar interaction partners. Across three experiments using an adaptation of the iterated Trust Game, we consistently observed a ‘social overshadowing’ effect, that is, a better learning about the cooperative tendencies of partners presented alone compared to those presented in a pair. This robust effect was not modulated by gender stereotypes or beliefs about the internal communication dynamics within a pair of partners. The implications of these results for both associative learning and social psychology are discussed.
DOI: 10.17639/nott.7176
title: The future of manufacturing: utopia or dystopia?

description: Utopic and Dystopic videos of the vision of what the future of Digital Manufacturing Technologies might look like. These videos were used for a research study presented in the paper: The Future of Manufacturing: Utopia or Dystopia?
DOI: 10.17639/nott.7164
title: Supporting people touched by cancer to attend parkrun. Exploring attendees’ experiences of the 5K Your Way, Move Against Cancer Initiative.

description: Purpose: 5KYW, Move Against Cancer (5KYW) is an unstudied UK-wide initiative that encourages individuals touched by cancer to engage in physical activity (PA). We explored attendees’ experiences of the initiative guided by the RE-AIM framework. Methods: 114 individuals completed a cross-sectional online questionnaire that included multiple-choice and free-text questions.
DOI: 10.17639/nott.7175
title: Force field parameter sets for 16 tetrahydroquinoline ligands

description: Force field parameter sets for free energy perturbation calculations of tetrahydroquinolines complexed to the first bromodomain of BRD4.
DOI: 10.17639/nott.7150
title: Supplementary Data for Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies

description: Showing single data points of small bowel water contents from 29 studies we collated in the paper "Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies". All studies are summarised in the first tab. A meta-analysis and analysis of postprandial drop are also presented.
DOI: 10.17639/nott.7187
title: Body sheets/ soma trajectories

description: In this file, there are body sheets and soma trajectories which were used during soma-informed workshops.
DOI: 10.17639/nott.7169
title: Registered Nurses’ experiences, perceptions and understanding and understanding of Computerised Decision Support Systems in a NHS hospital ward setting. Dissertation MA Research Methods (Health).

description: As this is qualitative data, it may identify the participant due to the rich nature of the data.
description: Purpose: To explore Registered Nurse’s experiences, understanding and perceptions of Computerised Decision Support Systems in the hospital ward setting. Primary Objectives: To explore how registered nurses use CDSS when decision making and the relationship between CDSS and clinical reasoning in clinical practice. Secondary Objectives: To understand how CDSS are introduced to Registered Nurses in a hospital ward setting. To explore barriers and facilitators to applying a CDSS to patient care in order to inform potential intervention(s). Research Protocol and Methods: This study has been designed as a pilot study. The findings of this study and the evaluation on the methods used for this study will inform a PhD Research Proposal for a larger study. A virtual, one to one, semi-structured interviews was used to explore the expectations, perceptions and experience of Registered Nurses using Computerised Decision Support Technologies. The findings were evaluated using thematic analysis. An inductive approach to data analysis was used (Braun and Clarke, 2006). This is anticipated to result in a rich understanding of the nurse’s experience of working with such technologies.