cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5285134.v3
title: Raw data: Mercury leaching ratio (μg/g) from Tibetan medicine Zuotai,β-HgS and α-HgS in pure water and artificial gastrointestinal juices containing Cys(or GSH) or not.

description: <i>Zuotai</i>, a known Tibetan
medicinal mixture containing insoluble cubic mercuric sulfide (β-HgS), has been
used to treat diseases with long history. The mercury leaching ratio from <i>Zuotai </i>in
gastrointestinal environment is one determinant factor for its bioavailability
and biological effect. However, the information is still scarce now. Therefore,
the study was designed to investigate the effect of sulfhydryl biomolecules
[L-cysteine (Cys) and glutathione (GSH)] on mercury leaching from <i>Zuotai</i>,
β-HgS, and α-HgS in artificial gastrointestinal juices or pure water.

The artificial gastric juice and artificial intestinal juice were prepared
according to the methods described in <i>Chinese Pharmacopoeia </i>(2010
version). The following solutions were prepared: Cys in pure water (5.21
g/L), GSH in pure water (13.21 g/L), Cys in artificial gastric juice (5.21
g/L), GSH in artificial gastric juice (13.21 g/L), Cys in artificial intestinal
juice (5.21 g/L), and GSH in artificial intestinal juice (13.21 g/L). The moles
of Cys and GSH in this study were 0.215 mmol—the same as that of β-HgS and
α-HgS. A solid-liquid ratio of 1:100 was adopted in all leaching experiments.
Digestion, peristalsis and emptying of drug in the gastrointestinal tract were
simulated <i>in vitro</i>. We detected the mercury released in solutions
using Automatic Direct Mercury Analyzer. Leaching Ratio of Mercury
(μg/g)=[Total Weight of Mercury Released (μg)]/[Total Weight of Substance
Tested (g)]

The results showed the following trend for
the mercury leaching ratio of<i> Zuotai</i>: artificial gastric juice &gt;
artificial intestinal juice &gt; pure water, whereas the trend for β-HgS and
α-HgS was as follows: artificial intestinal fluid &gt; artificial gastric fluid
&gt; pure water. The mercury leaching ratios of <i>Zuota</i>i, β-HgS, and
α-HgS significantly increased in artificial intestinal juice containing L-Cys
or GSH compared to that without sulfhydryl biomolecules in the juice. However,
in pure water and artificial gastric juice with Cys or GSH, the mercury
leaching ratio of <i>Zuotai </i>reduced remarkably, in contrast to
the results observed for β-HgS and α-HgS.
DOI: 10.6084/m9.figshare.5285152
title: Raw data: Leaching ratio (μg/g) of mercury from Tibetan medicine Zuotai,β-HgS and α-HgS in different pH solutions

description: <i>Zuotai</i>, a known Tibetan medicinal mixture
containing insoluble cubic mercuric sulfide (β-HgS), has been used to treat
diseases with long history. The mercury leaching ratio from <i>Zuotai </i>in gastrointestinal pH environment
is one determinant factor for its bioavailability and biological effect.
However, the information is still scarce now. Therefore, the study was designed
to investigate the mercury leaching from <i>Zuotai</i>,
β-HgS, and α-HgS in different pH solutionsSolutions
with different pH values (1–13) were prepared from pure water, HCl solution,
and NaOH solution; the pH was monitored using a pH meter. The solutions were as
follows: HCl solution with pH = 1, HCl solution with pH = 3, HCl solution with
pH = 5, NaOH solution with pH =
7, NaOH solution with pH = 9, NaOH solution with pH = 11, and NaOH solution
with pH = 13. A solid-liquid ratio of 1:100 was adopted in all leaching
experiments. Digestion, peristalsis and emptying of drug in the
gastrointestinal tract were simulated <i>in
vitro</i>. We detected the mercury released in solutions using Automatic Direct
Mercury Analyzer. Leaching Ratio of Mercury (μg/g)=[Total Weight of Mercury
Released (μg)]/[Total Weight of Substance Tested (g)]The results
showed that the mercury leaching
ratios of <i>Zuotai </i>at pH 1 and pH 13 were
significantly higher than those at each point within pH 3–11; the mercury leaching ratio of <i>Zuotai</i> at pH 1 was higher than that at pH 13. The mercury leaching ratio of β-HgS slightly decreased from pH 1 to pH 3
and significantly increased from pH 3 to pH 13. The mercury leaching ratio of
β-HgS at pH 13 was far higher than that at pH 1. For α-HgS,
the mercury leaching ratio also slightly decreased from pH 1 to pH 3 and then
gradually increased from pH 3 to pH 13. The mercury leaching ratio of α-HgS at
pH 1 was lower than that at pH 13.





Taken
together, strong acidic or strong alkaline environments would promote the
dissociation of mercury from <i>Zuotai</i>,
β-HgS, and α-HgS.
DOI: 10.6084/m9.figshare.5285152.v1
title: Raw data: Leaching ratio (μg/g) of mercury from Zuotai,β-HgS and α-HgS in different pH solutions

description: <i>Zuotai</i>, a known Tibetan medicinal mixture
containing insoluble cubic mercuric sulfide (β-HgS), has been used to treat
diseases with long history. The mercury leaching ratio from <i>Zuotai </i>in gastrointestinal pH environment
is one determinant factor for its bioavailability and biological effect.
However, the information is still scarce now. Therefore, the study was designed
to investigate the mercury leaching from <i>Zuotai</i>,
β-HgS, and α-HgS in different pH solutionsSolutions
with different pH values (1–13) were prepared from pure water, HCl solution,
and NaOH solution; the pH was monitored using a pH meter. The solutions were as
follows: HCl solution with pH = 1, HCl solution with pH = 3, HCl solution with
pH = 5, NaOH solution with pH =
7, NaOH solution with pH = 9, NaOH solution with pH = 11, and NaOH solution
with pH = 13. A solid-liquid ratio of 1:100 was adopted in all leaching
experiments. Digestion, peristalsis and emptying of drug in the
gastrointestinal tract were simulated <i>in
vitro</i>. We detected the mercury released in solutions using Automatic Direct
Mercury Analyzer. Leaching Ratio of Mercury (μg/g)=[Total Weight of Mercury
Released (μg)]/[Total Weight of Substance Tested (g)]The results
showed that the mercury leaching
ratios of <i>Zuotai </i>at pH 1 and pH 13 were
significantly higher than those at each point within pH 3–11; the mercury leaching ratio of <i>Zuotai</i> at pH 1 was higher than that at pH 13. The mercury leaching ratio of β-HgS slightly decreased from pH 1 to pH 3
and significantly increased from pH 3 to pH 13. The mercury leaching ratio of
β-HgS at pH 13 was far higher than that at pH 1. For α-HgS,
the mercury leaching ratio also slightly decreased from pH 1 to pH 3 and then
gradually increased from pH 3 to pH 13. The mercury leaching ratio of α-HgS at
pH 1 was lower than that at pH 13.





Taken
together, strong acidic or strong alkaline environments would promote the
dissociation of mercury from <i>Zuotai</i>,
β-HgS, and α-HgS.
DOI: 10.6084/m9.figshare.5285152.v2
title: Raw data: Leaching ratio (μg/g) of mercury from Tibetan medicine Zuotai,β-HgS and α-HgS in different pH solutions

description: <i>Zuotai</i>, a known Tibetan medicinal mixture
containing insoluble cubic mercuric sulfide (β-HgS), has been used to treat
diseases with long history. The mercury leaching ratio from <i>Zuotai </i>in gastrointestinal pH environment
is one determinant factor for its bioavailability and biological effect.
However, the information is still scarce now. Therefore, the study was designed
to investigate the mercury leaching from <i>Zuotai</i>,
β-HgS, and α-HgS in different pH solutionsSolutions
with different pH values (1–13) were prepared from pure water, HCl solution,
and NaOH solution; the pH was monitored using a pH meter. The solutions were as
follows: HCl solution with pH = 1, HCl solution with pH = 3, HCl solution with
pH = 5, NaOH solution with pH =
7, NaOH solution with pH = 9, NaOH solution with pH = 11, and NaOH solution
with pH = 13. A solid-liquid ratio of 1:100 was adopted in all leaching
experiments. Digestion, peristalsis and emptying of drug in the
gastrointestinal tract were simulated <i>in
vitro</i>. We detected the mercury released in solutions using Automatic Direct
Mercury Analyzer. Leaching Ratio of Mercury (μg/g)=[Total Weight of Mercury
Released (μg)]/[Total Weight of Substance Tested (g)]The results
showed that the mercury leaching
ratios of <i>Zuotai </i>at pH 1 and pH 13 were
significantly higher than those at each point within pH 3–11; the mercury leaching ratio of <i>Zuotai</i> at pH 1 was higher than that at pH 13. The mercury leaching ratio of β-HgS slightly decreased from pH 1 to pH 3
and significantly increased from pH 3 to pH 13. The mercury leaching ratio of
β-HgS at pH 13 was far higher than that at pH 1. For α-HgS,
the mercury leaching ratio also slightly decreased from pH 1 to pH 3 and then
gradually increased from pH 3 to pH 13. The mercury leaching ratio of α-HgS at
pH 1 was lower than that at pH 13.





Taken
together, strong acidic or strong alkaline environments would promote the
dissociation of mercury from <i>Zuotai</i>,
β-HgS, and α-HgS.
DOI: 10.6084/m9.figshare.5287708
title: Suijing18 short-read sequencing data part 1 based on Illumina 800bp library

description: The 800bp- libraries with peak insert size at at ~800 bp was prepared using aan Illumina Truseq DNA library protocol (Illumina Kit FC-121-4001; Illumina Inc., San Diego, CA, USA). The qualities of libraries were checked by using the a standard protocol involved in Agilent 2100 Bioanalyzer High Sensitivity Kit. After library profile analysis, the library was sequenced with by using pair-end 150 bp pair-end strategies on with the Illumina HiSeq X10 platform (Illumina Inc.). This is the part 1 of the 35.4Gb data from 800bp library with coverage of 88X for Suijing 18.
DOI: 10.6084/m9.figshare.5287708.v1
title: Suijing18 short-read sequencing data part 1 based on Illumina 800bp library

description: The 800bp- libraries with peak insert size at at ~800 bp was prepared using aan Illumina Truseq DNA library protocol (Illumina Kit FC-121-4001; Illumina Inc., San Diego, CA, USA). The qualities of libraries were checked by using the a standard protocol involved in Agilent 2100 Bioanalyzer High Sensitivity Kit. After library profile analysis, the library was sequenced with by using pair-end 150 bp pair-end strategies on with the Illumina HiSeq X10 platform (Illumina Inc.). This is the part 1 of the 35.4Gb data from 800bp library with coverage of 88X for Suijing 18.
DOI: 10.6084/m9.figshare.5287711
title: Suijing18 short-read sequencing data part 2 based on Illumina 800bp library

description: The 800bp- libraries with peak insert size at at ~800 bp was prepared using aan Illumina Truseq DNA library protocol (Illumina Kit FC-121-4001; Illumina Inc., San Diego, CA, USA). The qualities of libraries were checked by using the a standard protocol involved in Agilent 2100 Bioanalyzer High Sensitivity Kit. After library profile analysis, the library was sequenced with by using pair-end 150 bp pair-end strategies on with the Illumina HiSeq X10 platform (Illumina Inc.). This is the part 2 of the 35.4Gb data from 800bp library with coverage of 88X for Suijing 18.
DOI: 10.6084/m9.figshare.5287711.v1
title: Suijing18 short-read sequencing data part 2 based on Illumina 800bp library

description: The 800bp- libraries with peak insert size at at ~800 bp was prepared using aan Illumina Truseq DNA library protocol (Illumina Kit FC-121-4001; Illumina Inc., San Diego, CA, USA). The qualities of libraries were checked by using the a standard protocol involved in Agilent 2100 Bioanalyzer High Sensitivity Kit. After library profile analysis, the library was sequenced with by using pair-end 150 bp pair-end strategies on with the Illumina HiSeq X10 platform (Illumina Inc.). This is the part 2 of the 35.4Gb data from 800bp library with coverage of 88X for Suijing 18.
DOI: 10.6084/m9.figshare.5296270
title: ClustalW alignment for phylogenetic analysis of HT-58-2Cyano

description: Philip formatted output of ClustalW aligned 16S rRNA of HT-58-2Cyano and other cyanobacteria. Supporting data for the manuscript AEM01068-17 submitted to Applied and Environmental Microbiology.
DOI: 10.6084/m9.figshare.5296270.v1
title: ClustalW alignment for phylogenetic analysis of HT-58-2Cyano

description: Philip formatted output of ClustalW aligned 16S rRNA of HT-58-2Cyano and other cyanobacteria. Supporting data for the manuscript AEM01068-17 submitted to Applied and Environmental Microbiology.
DOI: 10.6084/m9.figshare.5297464.v1
title: Lack of association between the P413L variant of <i>chromogranin B</i> and ALS risk or age at onset: a meta-analysis

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is thought to result from interaction of genetic and environmental risk factors. Whether the potentially functional exonic P413L variant in the <i>chromogranin B</i> gene influences ALS risk and age at onset is controversial. <i>Method</i>: We meta-analysed or other studies assessing the association between the P413L variant and ALS risk or age at ALS onset indexed in Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases. <i>Results</i>: Five case-control studies were analysed, involving 2639 patients with sporadic ALS, 201 with familial ALS and 3381 controls. No association was detected between risk of either ALS type and the CT + TT genotype or T-allele of the P413L variant. Age at ALS onset was similar between carriers and non-carriers of the T-allele. <i>Conclusion</i>: The available evidence suggests that the P413L variant of <i>chromogranin B</i> is not associated with ALS risk or age at ALS onset. These results should be validated in large, well-designed studies.
DOI: 10.6084/m9.figshare.5297464
title: Lack of association between the P413L variant of <i>chromogranin B</i> and ALS risk or age at onset: a meta-analysis

description: <i>Background</i>: Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is thought to result from interaction of genetic and environmental risk factors. Whether the potentially functional exonic P413L variant in the <i>chromogranin B</i> gene influences ALS risk and age at onset is controversial. <i>Method</i>: We meta-analysed or other studies assessing the association between the P413L variant and ALS risk or age at ALS onset indexed in Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases. <i>Results</i>: Five case-control studies were analysed, involving 2639 patients with sporadic ALS, 201 with familial ALS and 3381 controls. No association was detected between risk of either ALS type and the CT + TT genotype or T-allele of the P413L variant. Age at ALS onset was similar between carriers and non-carriers of the T-allele. <i>Conclusion</i>: The available evidence suggests that the P413L variant of <i>chromogranin B</i> is not associated with ALS risk or age at ALS onset. These results should be validated in large, well-designed studies.
DOI: 10.6084/m9.figshare.5297608
title: Hu Li_tables_ESM.xlsx from Mitochondrial phylogenomics of Hemiptera reveals adaptive innovations driving the diversification of true bugs

description: Tables S1-S7
DOI: 10.6084/m9.figshare.5297608.v1
title: Hu Li_tables_ESM.xlsx from Mitochondrial phylogenomics of Hemiptera reveals adaptive innovations driving the diversification of true bugs

description: Tables S1-S7
DOI: 10.6084/m9.figshare.5306497
title: Data for: "Evolutionary history of Coleoptera revealed by extensive sampling of genes and species"

description: The raw sequences, concatenated datasets and phylogenetic results generated from the study "Zhang ert al. (2017) Evolutionary history of Coleoptera revealed by extensive sampling of genes and species"
DOI: 10.6084/m9.figshare.5306497.v1
title: Data for: "Evolutionary history of Coleoptera revealed by extensive sampling of genes and species"

description: The raw sequences, concatenated datasets and phylogenetic results generated from the study "Zhang ert al. (2017) Evolutionary history of Coleoptera revealed by extensive sampling of genes and species"
DOI: 10.6084/m9.figshare.5306671
title: Lake Catchment Set

description: A freely available data set of inflow lakes’ catchments including lakes, location, shape, area, perimeter, etc. over the Qiangtang Plateau which is a main part of the Tibetan Plateau. The data set is derived from Landset8 images, Google Earth and DEM. It will provide important basic information for researchers to study the changes of meteorology, hydrology and environment and its mechanism in Qinghai-Tibet Plateau.
DOI: 10.6084/m9.figshare.5306671.v1
title: Lake Catchment Set

description: A freely available data set of inflow lakes’ catchments including lakes, location, shape, area, perimeter, etc. over the Qiangtang Plateau which is a main part of the Tibetan Plateau. The data set is derived from Landset8 images, Google Earth and DEM. It will provide important basic information for researchers to study the changes of meteorology, hydrology and environment and its mechanism in Qinghai-Tibet Plateau.
DOI: 10.6084/m9.figshare.5307100
title: Petrogenesis of an early Eocene gabbro–granite complex in Kachang (SW Yunnan) and its implications for Eocene magmatism in the Tengchong terrane of SW China

description: Major and trace element, zircon U–Pb and Hf-isotope data are reported for mafic intrusions and host granite from the Kachang pluton (North Yingjiang of SW Yunnan) in the Tengchong Terrane, in order to investigate their sources, petrogenesis and tectonic implications. The zircon U–Pb age of the mafic rocks (~55 Ma) is identical to that of the host granite (56.7 ± 0.6 Ma). The mafic rocks have high MgO concentrations (up to 13.43 wt.%) at low SiO<sub>2</sub> contents (low to 42.73 wt.%) and slight negative to positive <i>ε</i>Hf(<i>t</i>) values (−2.26 to +0.59). They are enriched in LILE and LREEs and depleted in HFSEs, which can be explained as melts derived from a enriched mantle, with some crustal contamination. The host granite have high SiO<sub>2</sub> contents (69.18–72.65 wt.%), highly negative <i>ε</i>Hf(<i>t</i>) values (−9.08 to −5.14), suggesting mainly derived from an ancient crustal source. Field observations, geochronology, geochemistry and zircon Hf isotopic compositions point to a complex petrogenesis, where enriched mantle- and crust-derived magma mixing was coupled with crystal fractionation, thus explaining the genetic link between mafic and felsic magmas, result of mafic magma upwelling triggered by the subduction rollback of the Neotethyan slab. Our new data, along with the data reported (especially zircon U–Pb dating and Lu–Hf isotope data) in the Tengchong Terrane, indicate that the spatial and temporal variations and changing magmatic compositions over time in the Tengchong Terrane closely resemble those of the Lhasa Terrane in southern and central Tibet.
DOI: 10.6084/m9.figshare.5307100.v1
title: Petrogenesis of an early Eocene gabbro–granite complex in Kachang (SW Yunnan) and its implications for Eocene magmatism in the Tengchong terrane of SW China

description: Major and trace element, zircon U–Pb and Hf-isotope data are reported for mafic intrusions and host granite from the Kachang pluton (North Yingjiang of SW Yunnan) in the Tengchong Terrane, in order to investigate their sources, petrogenesis and tectonic implications. The zircon U–Pb age of the mafic rocks (~55 Ma) is identical to that of the host granite (56.7 ± 0.6 Ma). The mafic rocks have high MgO concentrations (up to 13.43 wt.%) at low SiO<sub>2</sub> contents (low to 42.73 wt.%) and slight negative to positive <i>ε</i>Hf(<i>t</i>) values (−2.26 to +0.59). They are enriched in LILE and LREEs and depleted in HFSEs, which can be explained as melts derived from a enriched mantle, with some crustal contamination. The host granite have high SiO<sub>2</sub> contents (69.18–72.65 wt.%), highly negative <i>ε</i>Hf(<i>t</i>) values (−9.08 to −5.14), suggesting mainly derived from an ancient crustal source. Field observations, geochronology, geochemistry and zircon Hf isotopic compositions point to a complex petrogenesis, where enriched mantle- and crust-derived magma mixing was coupled with crystal fractionation, thus explaining the genetic link between mafic and felsic magmas, result of mafic magma upwelling triggered by the subduction rollback of the Neotethyan slab. Our new data, along with the data reported (especially zircon U–Pb dating and Lu–Hf isotope data) in the Tengchong Terrane, indicate that the spatial and temporal variations and changing magmatic compositions over time in the Tengchong Terrane closely resemble those of the Lhasa Terrane in southern and central Tibet.
DOI: 10.6084/m9.figshare.5309725
title: Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification

description: Accumulation of intracellular misfolded or damaged proteins is associated with both normal aging and late-onset degenerative diseases. Two cellular clearance mechanisms, the ubiquitin-proteasome system (UPS) and the macroautophagy/autophagy-lysosomal pathway, work in concert to degrade harmful protein aggregates and maintain protein homeostasis. Here we show that Mask, an Ankyrin-repeat and KH-domain containing protein, plays a key role in promoting autophagy flux and mitigating degeneration caused by protein aggregation or impaired UPS function. In <i>Drosophila</i> eye models of human tauopathy or amyotrophic lateral sclerosis diseases, loss of Mask function enhanced, while gain of Mask function mitigated, eye degenerations induced by eye-specific expression of human pathogenic MAPT/TAU or FUS proteins. The fly larval muscle, a more accessible tissue, was then used to study the underlying molecular mechanisms in vivo. We found that Mask modulates the global abundance of K48- and K63-ubiquitinated proteins by regulating autophagy-lysosome-mediated degradation, but not UPS function. Indeed, upregulation of Mask compensated the partial loss of UPS function. We further demonstrate that Mask promotes autophagic flux by enhancing lysosomal function, and that Mask is necessary and sufficient for promoting the expression levels of the proton-pumping vacuolar (V)-type ATPases in a TFEB-independent manner. Moreover, the beneficial effects conferred by Mask expression on the UPS dysfunction and neurodegenerative models depend on intact autophagy-lysosomal pathway. Our findings highlight the importance of lysosome acidification in cellular surveillance mechanisms and establish a model for exploring strategies to mitigate neurodegeneration by boosting lysosomal function.