cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25403/upresearchdata.22094498
title: Nanoparticle cytotoxicity, lysosomal membrane permeabilisation and autophagy induction in kidney cells in vitro

description: Data collected in completion of a Masters of Science degree in Human Physiology.The datasets were aimed to investigate polyethylene glycol carboxyl gold nanoparticles (PEG-COOH AuNPs) uptake, cytotoxicity and possible autophagy induction in human embryonic kidney (HEK-293) cells in vitro. PEG-COOH AuNPs were firstly characterised in terms of their physicochemical properties when suspended in cell culture media and milli-Q water using transmission electron microscopy (TEM), absorbance spectroscopy, zeta potential meter and a pH meter. HEK 293 cells were then exposed to PEG-COOH AuNPs (0.5 nM -10 nM) for 24 hours and cytotoxicity was assessed using the xCELLigence real-time cell analyser (RTCA). Cellular uptake of PEG-COOH AuNPs (0.13 nM) was assessed using CytoViva dark-field microscopy. The internalisation of PEG-COOH AuNPs into vesicles was visualised using TEM. Analytical interference of the PEG?COOH AuNPs with the LysoTracker green staining dye and the Western blot protein quantification assay kit was assessed prior to employing these techniques. Lysosomal membrane permeabilsation (LMP) was investigated using LysoTracker green staining by flow cytometry and Western blotting of microtubule-associated protein 1 light chain 3 (LC3) was quantified to assess autophagy induction. PEG-COOH AuNPs caused cytotoxicity in HEK 293 cells with an IC50 of 1 nM. PEG-COOH AuNPs were internalised by the HEK 293 cells and an increased number of vacuoles were observed. PEG-COOH AuNPs did not induce LMP despite the accumulation of the PEG-COOH AuNPs in vacuoles. No conversion of LC3I-LC3II was observed. However, LysoTracker green staining with flow cytometry is not an optimal assay as the auto-fluorescent properties of PEG-COOH AuNPs caused analytical interference. No interference of the PEG-COOH AuNPs with the Western blot protein quantification assay kit was observed. Investigation into the potential systemic effects of these particles is warranted due to their toxicity.
DOI: 10.25403/upresearchdata.22094498.v1
title: Nanoparticle cytotoxicity, lysosomal membrane permeabilisation and autophagy induction in kidney cells in vitro

description: Data collected in completion of a Masters of Science degree in Human Physiology.The datasets were aimed to investigate polyethylene glycol carboxyl gold nanoparticles (PEG-COOH AuNPs) uptake, cytotoxicity and possible autophagy induction in human embryonic kidney (HEK-293) cells in vitro. PEG-COOH AuNPs were firstly characterised in terms of their physicochemical properties when suspended in cell culture media and milli-Q water using transmission electron microscopy (TEM), absorbance spectroscopy, zeta potential meter and a pH meter. HEK 293 cells were then exposed to PEG-COOH AuNPs (0.5 nM -10 nM) for 24 hours and cytotoxicity was assessed using the xCELLigence real-time cell analyser (RTCA). Cellular uptake of PEG-COOH AuNPs (0.13 nM) was assessed using CytoViva dark-field microscopy. The internalisation of PEG-COOH AuNPs into vesicles was visualised using TEM. Analytical interference of the PEG?COOH AuNPs with the LysoTracker green staining dye and the Western blot protein quantification assay kit was assessed prior to employing these techniques. Lysosomal membrane permeabilsation (LMP) was investigated using LysoTracker green staining by flow cytometry and Western blotting of microtubule-associated protein 1 light chain 3 (LC3) was quantified to assess autophagy induction. PEG-COOH AuNPs caused cytotoxicity in HEK 293 cells with an IC50 of 1 nM. PEG-COOH AuNPs were internalised by the HEK 293 cells and an increased number of vacuoles were observed. PEG-COOH AuNPs did not induce LMP despite the accumulation of the PEG-COOH AuNPs in vacuoles. No conversion of LC3I-LC3II was observed. However, LysoTracker green staining with flow cytometry is not an optimal assay as the auto-fluorescent properties of PEG-COOH AuNPs caused analytical interference. No interference of the PEG-COOH AuNPs with the Western blot protein quantification assay kit was observed. Investigation into the potential systemic effects of these particles is warranted due to their toxicity.
DOI: 10.21410/7e4/gx9dsw
title: La conversion écologique des Français: Contradictions et clivages, Puf, 2023 (Annexes de l'ouvrage)

description: Ce fichier contient les annexes de l'ouvrage" La conversion écologique des français", Puf, 2023, classées par chapitre - Graphiques et tableaux statistiques. Après quelques données de cadrage, internationales et historique, les données présentées sont issues de l'enquête SVEN 2017 "Styles de vie et Environnement" (ELIPSS/CDSP). Un sommaire est disponible sur le premier onglet.
DOI: 10.5281/zenodo.7656949
title: Analysis of symptoms and quality of life of people with prolonged diagnosis of COVID-19, and the efficacy of an intervention in primary care using ICT

description: This is a ranzomized clinical study called: “Analysis of symptoms and quality of life of people with prolonged diagnosis of COVID-19, and the efficacy of an intervention in primary care using ICT”, approved in mid-2020, with reference number ISRCTN91104012. The main objetive is to analyse the overall effectiveness and cost-efficiency of a mobile application (APP) as a community health asset (HA) with recommendations and recovery exercises created bearing in mind the main symptoms presented by Long COVID patients in order to improve their quality of life, as well as other secondary variables, such as the number and severity of ongoing symptoms, physical and cognitive functions, affective state, and sleep quality. The first step was to design and develop the technologic community resource, the APP, following the steps involved in the process of recommending health assets (RHA). After this, a protocol of a randomised clinical trial for analysing its effectiveness and cost-efficiency as a HA was developed. The participants will be assigned to: (1st) usual treatment by the primary care practitioner (TAU), as a control group; and (2nd) TAU + use of the APP as a HA and adjuvant treatment in their recovery + three motivational interviews (MI), as an interventional group. An evaluation will be carried out at baseline with further assessments three and six months following the end of the intervention.
DOI: 10.5281/zenodo.7656948
title: Analysis of symptoms and quality of life of people with prolonged diagnosis of COVID-19, and the efficacy of an intervention in primary care using ICT

description: This is a ranzomized clinical study called: “Analysis of symptoms and quality of life of people with prolonged diagnosis of COVID-19, and the efficacy of an intervention in primary care using ICT”, approved in mid-2020, with reference number ISRCTN91104012. The main objetive is to analyse the overall effectiveness and cost-efficiency of a mobile application (APP) as a community health asset (HA) with recommendations and recovery exercises created bearing in mind the main symptoms presented by Long COVID patients in order to improve their quality of life, as well as other secondary variables, such as the number and severity of ongoing symptoms, physical and cognitive functions, affective state, and sleep quality. The first step was to design and develop the technologic community resource, the APP, following the steps involved in the process of recommending health assets (RHA). After this, a protocol of a randomised clinical trial for analysing its effectiveness and cost-efficiency as a HA was developed. The participants will be assigned to: (1st) usual treatment by the primary care practitioner (TAU), as a control group; and (2nd) TAU + use of the APP as a HA and adjuvant treatment in their recovery + three motivational interviews (MI), as an interventional group. An evaluation will be carried out at baseline with further assessments three and six months following the end of the intervention.
DOI: 10.6084/m9.figshare.22010822.v1
title: Macroinvertebrate functional trait database of South Korean stream

description: Functional traits are the result of evolution and adaptation, providing important ecological insights into how organisms interact with their environment. Aquatic macroinvertebrates, in particular, have garnered attention as biomonitoring indicators for freshwater ecosystems. This study presents a functional trait database for benthic aquatic macroinvertebrates, comprising 440 genera from five phyla (Annelida, Arthropoda, Mollusca, Nematomorpha, and Platyhelmenthes), categorized into nine traits related to life history, morphology, and habit. To account for variation in available trait information, we assigned confidence levels to each taxon and functional trait based on the level of evidence using fuzzy coding. Our database provides a comprehensive resource for understanding the ecology of benthic macroinvertebrates, serving as a valuable baseline dataset for studying their biodiversity, conservation, and biomonitoring in freshwater ecosystems.
DOI: 10.18112/openneuro.ds004507.v1.0.0
title: PMJ BIDS Dataset
DOI: 10.57745/q74v3y
title: nostril_laterality.tab

description: :unav
DOI: 10.57745/tmrqdb
title: sniffing_duration.tab

description: :unav
DOI: 10.57745/ahoaqq
title: statistical analysis code.R

description: :unav
DOI: 10.6084/m9.figshare.22128797.v1
title: Untitled Item

description: Data of a cross environemnt experiment performed in the field
DOI: 10.6084/m9.figshare.19251758.v2
title: Swartz et al_2022_Bird functional traits and ecosystem services

description: Datasets and code necessary to reproduce analyses described in Swartz et al (2022).
DOI: 10.17632/sv846jk39p.1
title: raw data - A Complex Radiomic Signature in Luminal Breast Cancer from a Weighted Statistical Framework: A Pilot Study

description: Scientific research for publishing the article
DOI: 10.17632/btc7dzhz7v.1
title: The visual encoding of graspable unfamiliar objects

description: Scientific research for publishing the article
DOI: 10.17632/j6493yp8jd.1
title: Raw data-Prognostic Value of Coronary Calcium Score in Asymptomatic Individuals: A Systematic Review

description: Scientific research for publishing the article
DOI: 10.17632/8cyp2jz7c8.1
title: Clinical role of PRAME expression in melanocytic tumors: A single-center real-world retrospective study

description: Supplementary material: Demographic Features
DOI: 10.17632/dh25jzwxf8.1
title: Helicobacter pylori

description: Background and objectives: Peptic ulcer disease, chronic gastritis, and stomach cancer are all caused by H.
pylori. The most notable drug for the treatment is the antibiotic clarithromycin, which is currently the
drug of choice. H. pylori clarithromycin resistance has been associated with point mutations in
23srRNA, the most prominent of which are A2143 and A2144G. In H. pylori bacteria, methylase synthesis,
macrolide-inactivating enzyme activity, and active efflux have all been found to be resistance mechanisms. The goal of the study is to determine how resistant H. pylori is to clarithromycin and what the minimum inhibitory concentration is for various antimicrobials. Furthermore, gastro-endoscopy will be
performed on Iraqi patients to detect the presence of A2143G and A2144G point mutations in
Helicobacter pylori infections, as diagnosed from the pyloric region and other anatomical regions.
Methods: One hundred fifteen samples were collected from patients strongly suspected of H. pylori infection presented for upper gastrointestinal endoscopy at Ramadi Teaching Hospitals and Private Clinics for
the period from January 2020 until February 2021. Specimens were cultured on brain heart infusion agar
containing various antibiotics and were incubated at 37 C under microaerophilic conditions. For identification of H. pylori, isolates of the biochemical tests and RT-PCR assay were applied. The Epsilometer test
was used in the antibiotic susceptibility testing as dependent on the CLSI standard. The Restriction
Fragment Length Polymorphism technique was used to determine point mutations.
Results: In total, 55 (47.8%) Helicobacter pylori isolates were cultured from the 115 biopsy specimens,
among which 16 (29.1%), 38 (69.1%), 20 (36.4%), and 40 (72.7%) revealed some degree of resistance to
levofloxacin, clarithromycin, ciprofloxacin, and metronidazole, respectively. The frequency of A2144G
and A2143 point mutations were 23 (60.5%) and 19 (50%), respectively.
Conclusions: According to our results, Helicobacter pylori showed high resistance to clarithromycin. Our
results demonstrate the requirement for antibiotic susceptibility testing and molecular methods in
selecting drug regimens.
DOI: 10.17632/dh25jzwxf8.2
title: Helicobacter pylori

description: Background and objectives: Peptic ulcer disease, chronic gastritis, and stomach cancer are all caused by H.
pylori. The most notable drug for the treatment is the antibiotic clarithromycin, which is currently the
drug of choice. H. pylori clarithromycin resistance has been associated with point mutations in
23srRNA, the most prominent of which are A2143 and A2144G. In H. pylori bacteria, methylase synthesis,
macrolide-inactivating enzyme activity, and active efflux have all been found to be resistance mechanisms. The goal of the study is to determine how resistant H. pylori is to clarithromycin and what the minimum inhibitory concentration is for various antimicrobials. Furthermore, gastro-endoscopy will be
performed on Iraqi patients to detect the presence of A2143G and A2144G point mutations in
Helicobacter pylori infections, as diagnosed from the pyloric region and other anatomical regions.
Methods: One hundred fifteen samples were collected from patients strongly suspected of H. pylori infection presented for upper gastrointestinal endoscopy at Ramadi Teaching Hospitals and Private Clinics for
the period from January 2020 until February 2021. Specimens were cultured on brain heart infusion agar
containing various antibiotics and were incubated at 37 C under microaerophilic conditions. For identification of H. pylori, isolates of the biochemical tests and RT-PCR assay were applied. The Epsilometer test
was used in the antibiotic susceptibility testing as dependent on the CLSI standard. The Restriction
Fragment Length Polymorphism technique was used to determine point mutations.
Results: In total, 55 (47.8%) Helicobacter pylori isolates were cultured from the 115 biopsy specimens,
among which 16 (29.1%), 38 (69.1%), 20 (36.4%), and 40 (72.7%) revealed some degree of resistance to
levofloxacin, clarithromycin, ciprofloxacin, and metronidazole, respectively. The frequency of A2144G
and A2143 point mutations were 23 (60.5%) and 19 (50%), respectively.
Conclusions: According to our results, Helicobacter pylori showed high resistance to clarithromycin. Our
results demonstrate the requirement for antibiotic susceptibility testing and molecular methods in
selecting drug regimens.
DOI: 10.17632/5mzjjj556t.1
title: A Systematic Review of the Current Status and Quality of Radiomics for Glioma Differential Diagnosis

description: Scientific research for publishing the article
DOI: 10.5517/ccdc.csd.cc26hsdx
title: CCDC 2040959: Experimental Crystal Structure Determination

description: Related Article: Alakbar Huseynzada, Christian Jelsch, Haji Vahid Akhundzada, Sarra Soudani, Cherif Ben Nasr, Koray Sayin, Mustafa Demiralp, Ulviyya Hasanova, Goncha Eyvazova, Zarema Gakhramanova, Vagif Abbasov|2023|J.Iran.Chem.Soc.|20|109|doi:10.1007/s13738-022-02659-9
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc26hx0n
title: CCDC 2041071: Experimental Crystal Structure Determination

description: Related Article: Alakbar Huseynzada, Christian Jelsch, Haji Vahid Akhundzada, Sarra Soudani, Cherif Ben Nasr, Koray Sayin, Mustafa Demiralp, Ulviyya Hasanova, Goncha Eyvazova, Zarema Gakhramanova, Vagif Abbasov|2023|J.Iran.Chem.Soc.|20|109|doi:10.1007/s13738-022-02659-9
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.34740/kaggle/dsv/5033186
title: Cristiano Ronaldo | All Club Goals
DOI: 10.6084/m9.figshare.16832686
title: Inputs (.csv spreadsheets) for 'Conservation implications of a mismatch between data availability and demographic impact'

description: This dataset contains estimates of the following vital rates (as required to parameterise matrix population models), for the common eider (<em>Somateria mollissima</em>): 1st year survival (measured either from hatching, or from fledging, to 1 year old); 2nd year survival; adult annual survival; first breeding (both age-specific recruitment probability, and breeding propensity across potential recruitment ages); breeding propensity of established female breeders; clutch size; hatching success; and fledging success. These estimates are drawn from 134 studies, across the scientific and grey literature – including three previously inaccessible datasets on clutch size that were contributed in response to a call for data through the IUCN Species Survival Commission’s Duck Specialist Group (IDs 127, A and B). This is a relational database, linking estimates and associated metadata to the relevant study (or unique unpublished combination thereof) by a unique ID number in the 'MASTER' sheet. The files in this dataset closely correspond to those in the Dryad datatset linked below, with minor edits to facilitate their use in meta-analysis (see details in the README here). For further information, refer to the Dryad database (linked below), the Ecological Solutions and Evidence publication associated with that database (https://doi.org/10.1002/2688-8319.12108), or the pre-print entitled 'Conservation implications of a mismatch between data availability and demographic impact' (DOI: 10.22541/au.165337565.54669681/v1), which uses these inputs. There is also a 'probability matrix' .csv file, used for the background of pre-print Figure 4 (to be read into the output code), and equivalent plots for pre-print Appendix D (to be read into the comparative code). <br> ** 2023/02/20 edits - to MASTER, hs, and README - reflect minor corrections to the underlying Dryad database **
DOI: 10.6084/m9.figshare.16832686.v1
title: Inputs (.csv spreadsheets) for 'Conservation implications of a mismatch between data availability and demographic impact'

description: This dataset contains estimates of the following vital rates (as required to parameterise matrix population models), for the common eider (<em>Somateria mollissima</em>): 1st year survival (measured either from hatching, or from fledging, to 1 year old); 2nd year survival; adult annual survival; first breeding (both age-specific recruitment probability, and breeding propensity across potential recruitment ages); breeding propensity of established female breeders; clutch size; hatching success; and fledging success. These estimates are drawn from 134 studies, across the scientific and grey literature – including three previously inaccessible datasets on clutch size that were contributed in response to a call for data through the IUCN Species Survival Commission’s Duck Specialist Group (IDs 127, A and B). This is a relational database, linking estimates and associated metadata to the relevant study (or unique unpublished combination thereof) by a unique ID number in the 'MASTER' sheet. The files in this dataset closely correspond to those in the Dryad datatset linked below, with minor edits to facilitate their use in meta-analysis (see details in the README here). For further information, refer to the Dryad database (linked below), the Ecological Solutions and Evidence publication associated with that database (https://doi.org/10.1002/2688-8319.12108), or the pre-print entitled 'Conservation implications of a mismatch between data availability and demographic impact' (DOI: 10.22541/au.165337565.54669681/v1), which uses these inputs. There is also a 'probability matrix' .csv file, used for the background of pre-print Figure 4 (to be read into the output code), and equivalent plots for pre-print Appendix D (to be read into the comparative code).
DOI: 10.14459/2022mp1694147
title: Data for "Storage of mechanical energy in DNA nanorobotics using molecular torsion springs"

description: Data for the paper “Storage of mechanical energy in DNA nanorobotics using molecular torsion springs”. The data is structured by figure. The hdf5 files can be opened with the “Picasso” software package ( https://github.com/jungmannlab/picasso). The localizations in the hdf5 files show the tip position of the picked DNA robotic arms in each video frame with the “group” column representing the particle number. Accepted particles used for the analysis are specified in accompanying txt files. Frame times of the camera acquisition are written in the metadata txt file.
DOI: 10.5519/qd.gmw8zg7c
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (30102 records)
DOI: 10.17632/t83vnc635m.1
title: An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial

description: Scientific research for publishing the article
DOI: 10.25345/c5z02zk05
title: MassIVE MSV000091328 - Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role Of Hepatoma Derived Growth Factor, HIV, and Ethanol
title: Liver disease is one of the leading comorbidities in HIV infection. The risk of liver fibrosis development is potentiated by alcohol abuse. In our previous studies, we reported that hepatocytes exposed to HIV and acetaldehyde undergo significant apoptosis, and the engulfment of apoptotic bodies (ABs) by hepatic stellate cells (HSC) potentiates their pro-fibrotic activation. However, in addition to hepatocytes, under the same conditions, ABs can be generated from liver- infiltrating immune cells. The goal of this study is to explore whether lymphocyte-derived ABs trigger HSC profibrotic activation as strongly as hepatocyte-derived ABs. ABs were generated from Huh7.5-CYP2E1 (RLW) cells and Jurkat cells treated with HIV+acetaldehyde and co-culture with HSC to induce their pro-fibrotic activation. ABs cargo was analysed by proteomics. ABs generated from RLW, but not from Jurkat cells activated fibrogenic genes in HSC. This was driven by the expression of hepatocyte-specific proteins in ABs cargo. One of these proteins is Hepatocyte Derived Growth Factor, which suppression attenuates pro-fibrotic activation of HSC. In mice humanized with only immune cells but not human hepatocytes, infected with HIV and fed ethanol, liver fibrosis was not observed. We conclude that ABs of hepatocyte origin promote HSC activation and liver fibrosis development.
DOI: 10.5281/zenodo.7657656
title: GraalVM Compiler Benchmark Results Dataset 2019

description: This is the 2019 fragment of the GraalVM Compiler Benchmark Results Dataset. Check the other objects in this collection for documentation and scripting support.
DOI: 10.5281/zenodo.7657655
title: GraalVM Compiler Benchmark Results Dataset 2019

description: This is the 2019 fragment of the GraalVM Compiler Benchmark Results Dataset. Check the other objects in this collection for documentation and scripting support.