cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22785433
title: Bioactivity evaluation of least explored traditionally acclaimed medicinally potent herb Nanorrhinum ramosissimum(Wall.) Betsche

description: Abstract Present study analysed the therapeutic potential of traditionally acclaimed medicinal herb Nanorrhinum ramosissimum, using plant parts extracted with different solvents (10 mg/mL). Shoot extracts exhibited comparatively better antimicrobial properties, in comparison to root extracts. Total phenolic content was estimated, to ascertain its dependency on antioxidant properties of plant extracts. Antioxidant assay revealed promising results in comparison to IC50 value of standard ascorbic acid (52.2±0.07 µg/mL), for methanolic extracts of shoot (61.07±0.53 µg/mL and 64.33±0.33 µg/mL) and root (76.705±0.12 µg/mL and 89.73±0.28 µg/ mL) for in vivo and in vitro regenerants respectively. Correlation coefficient R2 values ranged between 0.90-0.95, indicating a positive correlation between phenolic contents and antioxidant activity. Plant extracts were also able to inhibit DNA oxidative damage again indicating their antioxidative potential. Antidiabetic potential was confirmed by alpha amylase inhibition assay where shoot methanolic extracts (invivo, in vitro) exhibited the best IC50 values (54.42±0.16 µg/mL, 66.09±0.12 µg/mL) in comparison to standard metformin (41.92±0.08 µg/mL). Ethanolic extracts of roots (in vitro, invivo) exhibited the relative IC50 values (88.97±0.32µg/mL,96.63±0.44 µg/mL) indicating that shoot parts had a better alpha amylase inhibition property; thus proving the herb’s bioactive potential and its prospective therapeutic source for curing various ailments.
DOI: 10.6084/m9.figshare.22785433.v1
title: Bioactivity evaluation of least explored traditionally acclaimed medicinally potent herb Nanorrhinum ramosissimum(Wall.) Betsche

description: Abstract Present study analysed the therapeutic potential of traditionally acclaimed medicinal herb Nanorrhinum ramosissimum, using plant parts extracted with different solvents (10 mg/mL). Shoot extracts exhibited comparatively better antimicrobial properties, in comparison to root extracts. Total phenolic content was estimated, to ascertain its dependency on antioxidant properties of plant extracts. Antioxidant assay revealed promising results in comparison to IC50 value of standard ascorbic acid (52.2±0.07 µg/mL), for methanolic extracts of shoot (61.07±0.53 µg/mL and 64.33±0.33 µg/mL) and root (76.705±0.12 µg/mL and 89.73±0.28 µg/ mL) for in vivo and in vitro regenerants respectively. Correlation coefficient R2 values ranged between 0.90-0.95, indicating a positive correlation between phenolic contents and antioxidant activity. Plant extracts were also able to inhibit DNA oxidative damage again indicating their antioxidative potential. Antidiabetic potential was confirmed by alpha amylase inhibition assay where shoot methanolic extracts (invivo, in vitro) exhibited the best IC50 values (54.42±0.16 µg/mL, 66.09±0.12 µg/mL) in comparison to standard metformin (41.92±0.08 µg/mL). Ethanolic extracts of roots (in vitro, invivo) exhibited the relative IC50 values (88.97±0.32µg/mL,96.63±0.44 µg/mL) indicating that shoot parts had a better alpha amylase inhibition property; thus proving the herb’s bioactive potential and its prospective therapeutic source for curing various ailments.
DOI: 10.6084/m9.figshare.22188007
title: Cardiovascular Statistics from the Good Practices in Cardiology Program – Data from a Brazilian Tertiary Public Hospital

description: Abstract Background The Good Practices in Cardiology Program is an initiative created by the Brazilian Society of Cardiology (SBC) to improve the quality of care of cardiovascular disease patients in Brazilian public hospitals. Objectives To characterize patients admitted to a tertiary public hospital with diagnosis of acute coronary syndrome (ACS) or heart failure (HF) and to evaluate performance indicators in both ACS and HF arms, with a pre-established target of 85% adherence to the SBC recommendations. Methods This was a descriptive cross-sectional study through data collection of patients hospitalized between May 2016 and September 2019. Results A total of 1,036 patients were included, 273 in the HF arm and 763 in the ACS arm. Mean age was 59.8 ± 12.0 years in the ACS and 57.0 ± 14.1 years in the HF, with a predominance of male patients in both groups. More than half of patients had some primary education and more than 90% reported a monthly income of less than five minimum wages. In ACS, the diagnosis of ACS with ST segment elevation was predominant (66.3%), and 2.9% of patients died. In HF, the most common etiology was Chagas disease (25.8%), and 17.9% died. Analysis of the performance indicators revealed an adherence rate higher than 85% to nine of the 12 indicators. Conclusion Quality programs are essential for improvement of quality of care. Performance indicators pointed to a good adherence to the SBC guidelines, mainly in the ACS arm.
DOI: 10.6084/m9.figshare.22188007.v1
title: Cardiovascular Statistics from the Good Practices in Cardiology Program – Data from a Brazilian Tertiary Public Hospital

description: Abstract Background The Good Practices in Cardiology Program is an initiative created by the Brazilian Society of Cardiology (SBC) to improve the quality of care of cardiovascular disease patients in Brazilian public hospitals. Objectives To characterize patients admitted to a tertiary public hospital with diagnosis of acute coronary syndrome (ACS) or heart failure (HF) and to evaluate performance indicators in both ACS and HF arms, with a pre-established target of 85% adherence to the SBC recommendations. Methods This was a descriptive cross-sectional study through data collection of patients hospitalized between May 2016 and September 2019. Results A total of 1,036 patients were included, 273 in the HF arm and 763 in the ACS arm. Mean age was 59.8 ± 12.0 years in the ACS and 57.0 ± 14.1 years in the HF, with a predominance of male patients in both groups. More than half of patients had some primary education and more than 90% reported a monthly income of less than five minimum wages. In ACS, the diagnosis of ACS with ST segment elevation was predominant (66.3%), and 2.9% of patients died. In HF, the most common etiology was Chagas disease (25.8%), and 17.9% died. Analysis of the performance indicators revealed an adherence rate higher than 85% to nine of the 12 indicators. Conclusion Quality programs are essential for improvement of quality of care. Performance indicators pointed to a good adherence to the SBC guidelines, mainly in the ACS arm.
DOI: 10.6084/m9.figshare.22785438
title: Antiproliferative effects of 13α/β-steroids on triple-negative MDA-MB-231 breast cancer cells: unraveling intracellular signaling without ERα

description: Abstract This study aimed to investigate the activities of novel 20(R)-3,20-dihydroxy-19-norpregn-1,3,5(10)-trienes (kuz7 and kuz8b) of natural 13β- and epimeric 13α-series against triple-negative MDA-MB-231 breast cancer cells. High antiproliferative activity of synthesized compounds kuz8b and kuz7 against MDA-MB-231 triple-negative cancer cells was revealed. The steroid kuz7 of natural 13β-configuration was more active against MDA-MB-231 cells than the 13α-steroid kuz8b. Cell cycle analysis revealed common patterns for the action of both tested compounds. The number of cells in the subG1 phase increased in a dose-dependent manner, indicating induction of apoptosis, which was also verified by PARP cleavage. In contrast, the number of cells in the G0/G1 phase decreases with increasing compound concentration. Steroid kuz7 at micromolar concentrations reduced the expression of GLUT1, a glucose transporter. High efficacy of the combination of kuz7 with biguanide metformin was shown, and synergistic effects on MDA-MB-231 cell growth and expression of the anti-apoptotic protein Bcl-2 were revealed. According to the obtained results, including the high activity of kuz7 against triple-negative cancer cells, the detected induction of apoptosis, and the decrease in GLUT1 expression, 13β-steroid kuz7 is of interest for further preclinical studies both alone and in combination with the metabolic drug metformin.
DOI: 10.6084/m9.figshare.22785438.v1
title: Antiproliferative effects of 13α/β-steroids on triple-negative MDA-MB-231 breast cancer cells: unraveling intracellular signaling without ERα

description: Abstract This study aimed to investigate the activities of novel 20(R)-3,20-dihydroxy-19-norpregn-1,3,5(10)-trienes (kuz7 and kuz8b) of natural 13β- and epimeric 13α-series against triple-negative MDA-MB-231 breast cancer cells. High antiproliferative activity of synthesized compounds kuz8b and kuz7 against MDA-MB-231 triple-negative cancer cells was revealed. The steroid kuz7 of natural 13β-configuration was more active against MDA-MB-231 cells than the 13α-steroid kuz8b. Cell cycle analysis revealed common patterns for the action of both tested compounds. The number of cells in the subG1 phase increased in a dose-dependent manner, indicating induction of apoptosis, which was also verified by PARP cleavage. In contrast, the number of cells in the G0/G1 phase decreases with increasing compound concentration. Steroid kuz7 at micromolar concentrations reduced the expression of GLUT1, a glucose transporter. High efficacy of the combination of kuz7 with biguanide metformin was shown, and synergistic effects on MDA-MB-231 cell growth and expression of the anti-apoptotic protein Bcl-2 were revealed. According to the obtained results, including the high activity of kuz7 against triple-negative cancer cells, the detected induction of apoptosis, and the decrease in GLUT1 expression, 13β-steroid kuz7 is of interest for further preclinical studies both alone and in combination with the metabolic drug metformin.
DOI: 10.6084/m9.figshare.22785441
title: Construction and validation of educational videos for adolescents with Down Syndrome based on health literacy – LISA Down Program

description: Abstract Objectives: to construct and validate educational videos as part of the LISA Down Program – Literacy and Innovation in Health for Adolescents with Down Syndrome. Methods: this is a methodological study of construction and validation of educational videos based on health literacy designed for adolescents with Down syndrome, assisted by an Associação de Pais e Amigos dos Excepcionais (APAE) (Association of Parents and Friends of the Exceptional) located in the Northeast of Brazil. The stages of construction and validation of the vídeos were: pre-production, production and post-production. The storyboards were prepared according to the fundamentals of health literacy and validated by seven expert judges. Subsequently, the storyboards were transformed into videos (production) and these were evaluated by 13 adolescents with Down Syndrome (postproduction). Results: the storyboards totaled 248 scenes, ranging from 39 to 67 scenes each, were approved by the judges with percentages of agreement ranging from 94% to 100%. The vídeos recorded were approved by adolescentes with Down syndrome, in agreement of percentages ranging from 79.17% to 83.33%. Conclusion: the educational vídeos were validated and well evaluated and, therefore, can be used among adolescents in social spaces in which the focus of attention is adolescentes with Down syndrome.
DOI: 10.6084/m9.figshare.22785441.v1
title: Construction and validation of educational videos for adolescents with Down Syndrome based on health literacy – LISA Down Program

description: Abstract Objectives: to construct and validate educational videos as part of the LISA Down Program – Literacy and Innovation in Health for Adolescents with Down Syndrome. Methods: this is a methodological study of construction and validation of educational videos based on health literacy designed for adolescents with Down syndrome, assisted by an Associação de Pais e Amigos dos Excepcionais (APAE) (Association of Parents and Friends of the Exceptional) located in the Northeast of Brazil. The stages of construction and validation of the vídeos were: pre-production, production and post-production. The storyboards were prepared according to the fundamentals of health literacy and validated by seven expert judges. Subsequently, the storyboards were transformed into videos (production) and these were evaluated by 13 adolescents with Down Syndrome (postproduction). Results: the storyboards totaled 248 scenes, ranging from 39 to 67 scenes each, were approved by the judges with percentages of agreement ranging from 94% to 100%. The vídeos recorded were approved by adolescentes with Down syndrome, in agreement of percentages ranging from 79.17% to 83.33%. Conclusion: the educational vídeos were validated and well evaluated and, therefore, can be used among adolescents in social spaces in which the focus of attention is adolescentes with Down syndrome.
DOI: 10.6084/m9.figshare.22785439
title: Change in oleoresin productivity between harvests and variable drillings of a Copaifera reticulata natural population in the Amazon

description: ABSTRACT Background: Many gaps in the copaifera oleoresin yield remain unfulfilled, preventing the sustainable management of this valuable non-timber forest product. This work aimed to characterize a natural Copaifera reticulata population in the Amazon rainforest, test different positions and depths in the trees to flow oleoresin, and analyze changes in the productiveness between two harvests ten months-spaced. The study was conducted in a Brazilian rainforest area at the Jari Ecological Station (ESEC) in 2017 and 2018, including 26 trees. Results: The diametric and height distributions evidenced light-demanding and mostly medium-class-diameter trees. The annual increment (0.45 ± 0.003 cm/year) was average, while the occurrence was rare. The area hosts yielding and unyielding trees, providing an average oleoresin production of 603.60 mL/tree. Oleoresin only flowed by reaching the inner heartwood or the pith. Oleoresin was not fully replenished after ten months, but the first drilling stimulated some unyielding trees to deliver it later. Collecting should focus on medium-diameter trees. Conclusion: The growth and distribution behaviors may challenge Copaifera’s sustainable management, which depends on the individual tree mechanisms to provide and replenish the oleoresin.
DOI: 10.6084/m9.figshare.22785439.v1
title: Change in oleoresin productivity between harvests and variable drillings of a Copaifera reticulata natural population in the Amazon

description: ABSTRACT Background: Many gaps in the copaifera oleoresin yield remain unfulfilled, preventing the sustainable management of this valuable non-timber forest product. This work aimed to characterize a natural Copaifera reticulata population in the Amazon rainforest, test different positions and depths in the trees to flow oleoresin, and analyze changes in the productiveness between two harvests ten months-spaced. The study was conducted in a Brazilian rainforest area at the Jari Ecological Station (ESEC) in 2017 and 2018, including 26 trees. Results: The diametric and height distributions evidenced light-demanding and mostly medium-class-diameter trees. The annual increment (0.45 ± 0.003 cm/year) was average, while the occurrence was rare. The area hosts yielding and unyielding trees, providing an average oleoresin production of 603.60 mL/tree. Oleoresin only flowed by reaching the inner heartwood or the pith. Oleoresin was not fully replenished after ten months, but the first drilling stimulated some unyielding trees to deliver it later. Collecting should focus on medium-diameter trees. Conclusion: The growth and distribution behaviors may challenge Copaifera’s sustainable management, which depends on the individual tree mechanisms to provide and replenish the oleoresin.
DOI: 10.6084/m9.figshare.22785445
title: Risk Factors of Thrombocytopenia After Cardiac Surgery with Cardiopulmonary Bypass

description: ABSTRACT Introduction: Postoperative thrombocytopenia is common in cardiac surgery with cardiopulmonary bypass, and its risk factors are unclear. Methods: This retrospective study enrolled 3,175 adult patients undergoing valve surgeries with cardiopulmonary bypass from January 1, 2017 to December 30, 2018 in our institute. Postoperative thrombocytopenia was defined as the first postoperative platelet count below the 10th quantile in all the enrolled patients. Outcomes between patients with and without postoperative thrombocytopenia were compared. The primary outcome was in-hospital mortality. Risk factors of postoperative thrombocytopenia were assessed by logistic regression analysis. Results: The 10th quantile of all enrolled patients (75×109/L) was defined as the threshold for postoperative thrombocytopenia. In-hospital mortality was comparable between thrombocytopenia and non-thrombocytopenia groups (0.9% vs. 0.6%, P=0.434). Patients in the thrombocytopenia group had higher rate of postoperative blood transfusion (5.9% vs. 3.2%, P=0.014), more chest drainage volume (735 [550-1080] vs. 560 [430-730] ml, P&lt;0.001), and higher incidence of acute kidney injury (12.3% vs. 4.2%, P&lt;0.001). Age &gt; 60 years (odds ratio [OR] 2.25, 95% confidence interval [CI] 1.345-3.765, P=0.002], preoperative thrombocytopenia (OR 18.671, 95% CI 13.649-25.542, P&lt;0.001), and cardiopulmonary bypass time (OR 1.088, 95% CI 1.059-1.117, P&lt;0.001) were positively independently associated with postoperative thrombocytopenia. Body surface area (BSA) (OR 0.247, 95% CI 0.114-0.538, P&lt;0.001) and isolated mitral valve surgery (OR 0.475, 95% CI 0.294-0.77) were negatively independently associated with postoperative thrombocytopenia. Conclusion: Positive predictors for thrombocytopenia after valve surgery included age &gt; 60 years, small BSA, preoperative thrombocytopenia, and cardiopulmonary bypass time. BSA and isolated mitral valve surgery were negative predictors.
DOI: 10.6084/m9.figshare.22785445.v1
title: Risk Factors of Thrombocytopenia After Cardiac Surgery with Cardiopulmonary Bypass

description: ABSTRACT Introduction: Postoperative thrombocytopenia is common in cardiac surgery with cardiopulmonary bypass, and its risk factors are unclear. Methods: This retrospective study enrolled 3,175 adult patients undergoing valve surgeries with cardiopulmonary bypass from January 1, 2017 to December 30, 2018 in our institute. Postoperative thrombocytopenia was defined as the first postoperative platelet count below the 10th quantile in all the enrolled patients. Outcomes between patients with and without postoperative thrombocytopenia were compared. The primary outcome was in-hospital mortality. Risk factors of postoperative thrombocytopenia were assessed by logistic regression analysis. Results: The 10th quantile of all enrolled patients (75×109/L) was defined as the threshold for postoperative thrombocytopenia. In-hospital mortality was comparable between thrombocytopenia and non-thrombocytopenia groups (0.9% vs. 0.6%, P=0.434). Patients in the thrombocytopenia group had higher rate of postoperative blood transfusion (5.9% vs. 3.2%, P=0.014), more chest drainage volume (735 [550-1080] vs. 560 [430-730] ml, P&lt;0.001), and higher incidence of acute kidney injury (12.3% vs. 4.2%, P&lt;0.001). Age &gt; 60 years (odds ratio [OR] 2.25, 95% confidence interval [CI] 1.345-3.765, P=0.002], preoperative thrombocytopenia (OR 18.671, 95% CI 13.649-25.542, P&lt;0.001), and cardiopulmonary bypass time (OR 1.088, 95% CI 1.059-1.117, P&lt;0.001) were positively independently associated with postoperative thrombocytopenia. Body surface area (BSA) (OR 0.247, 95% CI 0.114-0.538, P&lt;0.001) and isolated mitral valve surgery (OR 0.475, 95% CI 0.294-0.77) were negatively independently associated with postoperative thrombocytopenia. Conclusion: Positive predictors for thrombocytopenia after valve surgery included age &gt; 60 years, small BSA, preoperative thrombocytopenia, and cardiopulmonary bypass time. BSA and isolated mitral valve surgery were negative predictors.
DOI: 10.6084/m9.figshare.22785447
title: Dimensions of the use of technology and Artificial Intelligence (AI) in Recruitment and Selection (R&S): benefits, trends, and resistance

description: Abstract This study investigates the dimensions of the use of technological devices, including Artificial Intelligence (AI) in Recruitment and Selection (R&S) processes, from the perspective of recruiters from pharmaceutical companies located in the state of São Paulo. A qualitative research was carried out, through a semi-structured interviews with 12 people with experience in R&S before and after the advent of technology. The benefits, trends, and resistance regarding the use of technology and AI in R&S processes were verified. One benefit is the role of technology and AI in reducing the bureaucracy of HR, leaving it with a more strategic and consultative focus, by reducing time and cost in screening CVs and selecting candidates. A trend was that the pandemic brought a paradigm shift in the use of technologies in the R&S process, which should be used, either fully or partially, for a greater range of vacancies. Resistance was found in the skepticism about the assertiveness in candidate selection from the use of technology and AI due to the reduction of human contact. The ambiguous questions about the implications of the use of technology and AI on business diversity were also discussed. Suggestions for future research and research limitations were also presented.
DOI: 10.6084/m9.figshare.22785447.v1
title: Dimensions of the use of technology and Artificial Intelligence (AI) in Recruitment and Selection (R&S): benefits, trends, and resistance

description: Abstract This study investigates the dimensions of the use of technological devices, including Artificial Intelligence (AI) in Recruitment and Selection (R&S) processes, from the perspective of recruiters from pharmaceutical companies located in the state of São Paulo. A qualitative research was carried out, through a semi-structured interviews with 12 people with experience in R&S before and after the advent of technology. The benefits, trends, and resistance regarding the use of technology and AI in R&S processes were verified. One benefit is the role of technology and AI in reducing the bureaucracy of HR, leaving it with a more strategic and consultative focus, by reducing time and cost in screening CVs and selecting candidates. A trend was that the pandemic brought a paradigm shift in the use of technologies in the R&S process, which should be used, either fully or partially, for a greater range of vacancies. Resistance was found in the skepticism about the assertiveness in candidate selection from the use of technology and AI due to the reduction of human contact. The ambiguous questions about the implications of the use of technology and AI on business diversity were also discussed. Suggestions for future research and research limitations were also presented.
DOI: 10.6084/m9.figshare.22785450
title: CHEMISTRY IN PRIMO LEVI’S LITERATURE: PHILOSOPHICAL ASPECTS ON EXPERIMENTATION, MATTER AND THE PROFESSION OF CHEMISTRY

description: The Italian chemist Primo Levi (1919-1987) published a testimonial literature about the period he was captive in Auschwitz, later exploring other literary genres. In his work as a whole, the science-art relationship takes place both in terms of content (when chemistry and scientific knowledge are themes) and form (when the author appropriates the language and logic of science to communicate his experiences, especially those lived in the concentration camp). Three themes related to the chemical universe are present in Levi’s writings: experiments, man’s relationship with matter and chemistry as a work. In this article, we bring these topics closer to current discussions in the field of philosophy of chemistry. The philosophical discussion and Primo Levi’s literature converge on the understanding that experiments assumes a particular role in chemistry, that matter is a central category for this science and that the chemical profession raises ethical questions, such as those related to impacts of the incessant production of new substances.