cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26019282
title: Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages

description: Our research aimed to investigate the therapeutic effects of Tubastatin-A, a glucocorticoid receptor (GR) mitochondrial translocation inhibitor, and mitoquinone (MitoQ), an antioxidant, on attenuating dexamethasone (DEX)-induced macrophage apoptosis. We treated RAW264.7 macrophages with different combinations of DEX and either Tubastatin-A or MitoQ. Parameters such as mitochondrial GR translocation, mitochondrial reactive oxygen species levels, mitochondrial membrane potential, mitochondrial permeability transition pore opening, cytochrome C efflux to the cytosol, and apoptosis were subsequently evaluated in the different treatment groups <i>via</i> qRT–PCR, western blotting, and immunofluorescence assays. DEX intervention increased the translocation of GRs into the mitochondria, while reducing the expression of the mitochondrial gene MT-CO1 and the activity of mitochondrial respiratory chain complex IV in macrophages. In addition, DEX administration increased mtROS levels, mitochondrial permeability transition pore opening, and mitochondrial cytochrome C release in macrophages, which promoted their apoptosis. We found that Tubastatin-A inhibited mitochondrial GR translocation and reversed the DEX-induced increase in GR levels within the mitochondria. Furthermore, Tubastatin-A mitigated various mitochondrial changes induced by DEX, including reducing the efflux of mitochondrial cytochrome C and inhibiting macrophage apoptosis. Similarly, MitoQ exerted its effects on macrophage apoptosis by reducing mtROS levels through the mitochondrial pathway. The DEX-mediated translocation of GR into mitochondria disrupts the mitochondrial function of macrophages, which induces their apoptosis. By inhibiting mitochondrial translocation of GR and reducing mtROS levels, Tubastatin-A and MitoQ can effectively attenuate macrophage apoptosis, which has clinical implications for reducing the notable side effects associated with glucocorticoid use.
DOI: 10.6084/m9.figshare.26019282.v2
title: Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages

description: Our research aimed to investigate the therapeutic effects of Tubastatin-A, a glucocorticoid receptor (GR) mitochondrial translocation inhibitor, and mitoquinone (MitoQ), an antioxidant, on attenuating dexamethasone (DEX)-induced macrophage apoptosis. We treated RAW264.7 macrophages with different combinations of DEX and either Tubastatin-A or MitoQ. Parameters such as mitochondrial GR translocation, mitochondrial reactive oxygen species levels, mitochondrial membrane potential, mitochondrial permeability transition pore opening, cytochrome C efflux to the cytosol, and apoptosis were subsequently evaluated in the different treatment groups <i>via</i> qRT–PCR, western blotting, and immunofluorescence assays. DEX intervention increased the translocation of GRs into the mitochondria, while reducing the expression of the mitochondrial gene MT-CO1 and the activity of mitochondrial respiratory chain complex IV in macrophages. In addition, DEX administration increased mtROS levels, mitochondrial permeability transition pore opening, and mitochondrial cytochrome C release in macrophages, which promoted their apoptosis. We found that Tubastatin-A inhibited mitochondrial GR translocation and reversed the DEX-induced increase in GR levels within the mitochondria. Furthermore, Tubastatin-A mitigated various mitochondrial changes induced by DEX, including reducing the efflux of mitochondrial cytochrome C and inhibiting macrophage apoptosis. Similarly, MitoQ exerted its effects on macrophage apoptosis by reducing mtROS levels through the mitochondrial pathway. The DEX-mediated translocation of GR into mitochondria disrupts the mitochondrial function of macrophages, which induces their apoptosis. By inhibiting mitochondrial translocation of GR and reducing mtROS levels, Tubastatin-A and MitoQ can effectively attenuate macrophage apoptosis, which has clinical implications for reducing the notable side effects associated with glucocorticoid use.
DOI: 10.15468/dl.6ryjys
title: Occurrence Download

description: A dataset containing 745191 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Xeno-canto - Bird sounds from around the world"
 ]
}

 The dataset includes 745191 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043066-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.26410852
title: Supplementary Material for: Giant cell temporal arteritis followed by severe encephalopathy induced by immunotherapy in a patient with metastatic renal cell carcinoma achieving durable partial response: A case report

description: Introduction: Combined immune-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, they are often accompanied with a wide spectrum of immune-related adverse effects (irAEs). Case Presentation: We describe a case of rare irAEs manifested as giant cell temporal arteritis (GCA) followed by severe encephalopathy occurring after continuing immunotherapy in a 66-year-old man with mRCC receiving combination of ipilimumab and nivolumab in the first line of systemic therapy. GCA occurred four months after the initiation of IO and responded promptly to the low-dose prednisone therapy. Four months after continuation of nivolumab maintenance, the patient was hospitalized due to severe irAE encephalopathy which presented as psycho-behavioral abnormalities and progressive cognitive decline. He was treated with high-dose methylprednisolone which led to complete resolution of the symptoms and IO was permanently discontinued. The patient achieved a durable partial response. Conclusion: Both GCA and the subsequent encephalopathy in our patient responded well to the corticosteroid therapy, leading to the complete resolution of the symptoms and the patient achieved durable partial response. Although, the risk of severe neurologic irAEs affecting central nervous system induced by IO re-administration, following previous discontinuation due to irAE, is not well-defined because of their rarity, this case highlights the need for caution, particularly in cases with a history of previous irAE-associated GCA.
DOI: 10.6084/m9.figshare.26410852.v1
title: Supplementary Material for: Giant cell temporal arteritis followed by severe encephalopathy induced by immunotherapy in a patient with metastatic renal cell carcinoma achieving durable partial response: A case report

description: Introduction: Combined immune-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, they are often accompanied with a wide spectrum of immune-related adverse effects (irAEs). Case Presentation: We describe a case of rare irAEs manifested as giant cell temporal arteritis (GCA) followed by severe encephalopathy occurring after continuing immunotherapy in a 66-year-old man with mRCC receiving combination of ipilimumab and nivolumab in the first line of systemic therapy. GCA occurred four months after the initiation of IO and responded promptly to the low-dose prednisone therapy. Four months after continuation of nivolumab maintenance, the patient was hospitalized due to severe irAE encephalopathy which presented as psycho-behavioral abnormalities and progressive cognitive decline. He was treated with high-dose methylprednisolone which led to complete resolution of the symptoms and IO was permanently discontinued. The patient achieved a durable partial response. Conclusion: Both GCA and the subsequent encephalopathy in our patient responded well to the corticosteroid therapy, leading to the complete resolution of the symptoms and the patient achieved durable partial response. Although, the risk of severe neurologic irAEs affecting central nervous system induced by IO re-administration, following previous discontinuation due to irAE, is not well-defined because of their rarity, this case highlights the need for caution, particularly in cases with a history of previous irAE-associated GCA.
DOI: 10.34740/kaggle/dsv/9071781
title: Egypt Gold Prices | Daily Updated
DOI: 10.15468/dl.kvad8c
title: Occurrence Download

description: A dataset containing 705987 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hypericum perforatum L."
 ]
}

 The dataset includes 705987 records from 3935 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0043068-240626123714530/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/4fp-0cf-yc4
title: Beta vulgaris subsp. vulgaris L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/fbj-wd1-9vs
title: Glyceria fluitans (L.) R. Br.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/t5q-10h-bks
title: Cardaminopsis arenosa (L.) Hayek

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/bxr-zba-pnz
title: Scutellaria galericulata L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/c8d-5cf-ak0
title: Salix viminalis L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/4rk-vbn-zbp
title: Clematis integrifolia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/a0p-27g-r6c
title: Salix eleagnos Scop.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/c8w-7xf-891
title: Cerastium brachypetalum Desp. ex Pers.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/922-gws-2pe
title: Bromus japonicus Thunb. ex Murray

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/m1r-zk8-0mj
title: Poa badensis Haenke ex Willd.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/trj-fvk-87n
title: Poa palustris L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/cx5-5d0-jd9
title: Herniaria glabra subsp. rotundifolia (Vis.) Trpin

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/gp4-ysa-2el
title: Campanula barbata L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/znt4bh
title: Données naturalistes opportunistes issues de la plateforme INaturalist-Données naturalistes opportunistes "dragonfyre"

description: Données naturalistes opportunistes saisies sur iNaturalist à partir du compte "dragonfyre"
DOI: 10.3535/7ve-tyq-hnn
title: Deschampsia cespitosa (L.) P. Beauv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/fka-grm-bb8
title: Sorghum halepense (L.) Pers.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/jyl-m31-pms
title: Viola stagnina Kit. ex Schult.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/k5e-p9h-4gr
title: Salix aurita L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/0ff-dm8-zj7
title: Scutellaria hastifolia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ela-d84-1lp
title: Vulpia myuros (L.) C. C. Gmel.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/fkq-7b5-4d5
title: Arenaria serpyllifolia var. serpyllifolia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/b0e-xva-0vg
title: Valerianella turgida (Steven) Betcke

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/emh-jrp-8ma
title: Amelanchier ovalis Medik.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/llh-ggf-ntg
title: Corynephorus canescens (L.) P. Beauv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/5hs-dk1-735
title: Koeleria pyramidata subsp. pyramidata (Lam.) P. Beauv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/r5c-0m7-f0k
title: Poa hybrida Gaudin

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/6tm-d74-vty
title: Primula veris subsp. veris L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/heg-0ly-l0p
title: Pyrola minor L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/khz-33a-rcq
title: Salix breviserrata Flod.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/152-7m6-zqw
title: Malva sylvestris var. mauritiana (L.) Boiss.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/74k-0y4-fts
title: Castilleja coccinea (L.) Spreng.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9mv-zvb-5kv
title: Danthonia decumbens (L.) DC.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/3xa-qhq-4hk
title: Cruciata laevipes Opiz

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/7nn-a5d-42d
title: Poa hybrida Gaudin

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/gt1-bw8-sny
title: Salix viminalis L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/khb-5b2-zdz
title: Bromus arvensis L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/qrh-r1m-mkj
title: Helictotrichon adsurgens subsp. adsurgens (Schur ex Simonk.) Conert

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/44q-ba6-hy1
title: Moehringia trinervia (L.) Clairv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/mem-ll4-lj6
title: Cicuta virosa L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/tcx-jnm-h0n
title: Suaeda maritima (L.) Dumort.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/x1h-0pq-4f2
title: Bromus japonicus Thunb. ex Murray

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/63v-et4-nbl
title: Bromus hordeaceus L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/vfg-jjy-mjy
title: Festuca rupicola Heuff.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/6c2-zn8-xx3
title: Salix eleagnos Scop.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/rrp-4s4-18j
title: Calamagrostis canescens (Weber) Roth

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/xjt-j82-w7v
title: Arabis turrita L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/22l-jf1-dhf
title: Atriplex prostrata Boucher ex DC.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/8aw-n62-21z
title: Salix triandra subsp. amygdalina (L.) Schübl. & G. Martens

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/mpq-06h-sa7
title: Arabis turrita L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/4wm-bjs-5ma
title: Danthonia decumbens (L.) DC.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/80x-2p2-ajk
title: Atriplex prostrata Boucher ex DC.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/qf5-7a1-cq2
title: Arenaria serpyllifolia var. serpyllifolia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/3qb-ntp-lge
title: Centaurea jacea subsp. macroptilon (Borbás) Hayek

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/qal-cgw-qpn
title: Veronica austriaca subsp. jacquinii (Baumg.) K. Malý

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/z02-ta9-nx2
title: Panicum dichotomiflorum Michx.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ak7-vsz-abr
title: Sambucus racemosa L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/d6c-yc4-tdm
title: Portulaca oleracea subsp. granulatostellulata (Poelln.) Danin & H. G. Baker

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/6tv-wqz-zrb
title: Lilium martagon L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/n8s-1mp-h51
title: Salix glabra Scop.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/tv8-wsq-6ec
title: Stellaria montana Pierrat

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/aqq-lqx-vh9
title: Panicum capillare L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/qva-81d-43m
title: Festuca versicolor subsp. brachystachys (Hack.) Markgr.-Dann.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/wb6-y19-khy
title: Salix waldsteiniana Willd.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ke0-2gs-7hy
title: Allium schoenoprasum L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/s6p-pz4-ftm
title: Atriplex prostrata Boucher ex DC.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/z0y-jje-asj
title: Salix waldsteiniana Willd.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/2jm-p2r-xew
title: Dianthus sylvestris subsp. sylvestris Wulfen

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/k3v-psz-g7a
title: Festuca diffusa Dumort.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/vaq-v02-j54
title: Brachypodium sylvaticum (Huds.) P. Beauv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/39x-jas-9nx
title: Aesculus hippocastanum L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/8xd-yze-d2l
title: Stellaria media subsp. media (L.) Vill.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/gcj-dcd-18s
title: Setaria faberi R. A. W. Herrm.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ba5-e3l-w40
title: Trisetum distichophyllum (Vill.) P. Beauv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/pwt-9le-ym6
title: Mentha longifolia (L.) L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/687-8nj-l35
title: Avenula versicolor (Vill.) M. Laínz

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/pxs-gam-b0m
title: Panicum miliaceum subsp. agricola H. Scholz & Mikoláš

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/q5n-2y3-9l8
title: Camphorosma monspeliaca L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/1sn-peh-aql
title: Aconitum lycoctonum subsp. vulparia (Rchb.) Ces. x Aconitum lycoctonum subsp. ranunculifolium (Rchb. ex Spreng.) Schinz & Thel.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/a63-a94-axg
title: Persicaria lapathifolia subsp. lapathifolia (L.) Delarbre

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/zvk-3zl-6rm
title: Apera interrupta (L.) P. Beauv.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/43f-9fs-hpb
title: Viola pumila Chaix

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9dv-3m1-cgr
title: Digitaria ischaemum (Schreb.) Muhl.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/m31-7c5-677
title: Salix cinerea L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/nhwjbt
title: Données naturalistes opportunistes issues de la plateforme INaturalist-Données naturalistes opportunistes "nirinabe"

description: Données naturalistes opportunistes saisies sur iNaturalist à partir du compte "nirinabe"
DOI: 10.3535/2dt-vsm-0xa
title: Setaria faberi R. A. W. Herrm.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/6de-jes-hcc
title: Arenaria serpyllifolia var. viscida (Haller f. ex Loisel.) Halácsy

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/k2n-33j-g23
title: Dactylis glomerata L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.15468/dl.ugcqf3
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Aves)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 },
 "Geometry POLYGON((157.5 82.5,165 82.5,165 90,157.5 90,157.5 82.5))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034606-251009101135966/datasets/export for details.
DOI: 10.3535/715-v6t-xdk
title: Salix eleagnos Scop.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/b26-me7-gv2
title: Panicum schinzii Hack.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/h27-ztz-4v6
title: Poa alpina L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9d5-ksm-qb0
title: Trifolium stellatum L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/ns7-df3-5p3
title: Cardamine trifolia L.

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/rzj-fmw-k1l
title: Portulaca oleracea subsp. granulatostellulata (Poelln.) Danin & H. G. Baker

description: Digital Specimen for the physical specimen hosted at University of Graz.
DOI: 10.3535/9ak-2av-f7a
title: Populus tremula L.

description: Digital Specimen for the physical specimen hosted at University of Graz.