cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7231343
title: Dataset for: Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase (CaMKK) Exacerbates Impairment of Endothelial Cell and Blood-Brain Barrier after Stroke

description: Brain microvascular endothelial cells play an essential role in maintaining blood-brain barrier (BBB) integrity, and disruption of the BBB aggravates the ischemic injury. CaMKK (α and β) is a major kinase activated by elevated intracellular calcium. Previously, we demonstrated that inhibition of CaMKK exacerbated outcomes, conversely, overexpression reduced brain injury after stroke in mice. Interestingly, CaMKK has been shown to activate a key endothelial protector, Sirtuin 1 (SIRT1). We hypothesized that CaMKK protects brain endothelial cells via SIRT1 activation after stroke. In this study, Oxygen-Glucose Deprivation (OGD) was performed in human brain microvascular endothelial cells. Stroke was induced by middle cerebral artery occlusion (MCAO) in male mice. Knockdown of CaMKK β using siRNA increased cell death following OGD. Inhibition of CaMKK β by STO-609 significantly and selectively down-regulated levels of phosphorylated SIRT1 after OGD. Changes in the downstream targets of SIRT1 were observed following STO-609 treatment. The effect of STO-609 on cell viability after OGD was absent when SIRT1 was concurrently inhibited. We also demonstrated that STO-609 increased endothelial expression of the pro-inflammatory proteins ICAM-1 and VCAM-1 and inhibition of CaMKK exacerbated OGD-induced leukocyte-endothelial adhesion. Finally, intracerebroventricular injection of STO-609 exacerbated endothelial apoptosis and reduced BBB integrity after 24-hour reperfusion following MCAO in vivo. Collectively, these results demonstrated that CaMKK inhibition reduced endothelial cell viability, exacerbated inflammatory responses and aggravated BBB impairment after ischemia. CaMKK activation may attenuate ischemic brain injury via protection of the microvascular system and a reduction in the infiltration of pro-inflammatory factors.
DOI: 10.6084/m9.figshare.7231340.v1
title: Dataset for: Pharmacological induction of Heat Shock Protein 70 by celastrol protects motoneurons from excitotoxicity in the rat spinal cord in vitro

description: The secondary phase of spinal cord injury arising after the primary lesion largely extends the damage severity with delayed negative consequences for sensory-motor pathways. It is, therefore, important to find out if enhancing intrinsic mechanisms of neuroprotection can spare motoneurons that are very vulnerable cells. This issue was investigated with an in vitro model of rat spinal cord excitotoxicity monitored for up to 24 h after the primary injury evoked by kainate. The present study sought to pharmacologically boost the expression of heat shock proteins (HSP) to protect spinal motoneurons using celastrol to investigate if the rat spinal cord can upregulate HSP as neuroprotective mechanism. Despite its narrow range of drug safety in vitro, celastrol was not toxic to the rat spinal cord at 0.75 M concentration and enhanced the expression of HSP70 by motoneurons. When celastrol was applied either before or after kainate, the number of dead motoneurons was significantly decreased and the nuclear localization of the cell death biomarker AIF strongly inhibited. Nevertheless, electrophysiological recording showed that protection of lumbar motor networks by celastrol was rather limited as reflex activity was impaired and fictive locomotion largely depressed, suggesting that functional deficit persisted, though the networks could express slow rhythmic oscillations. While our data do not exclude further recovery at later times beyond the experimental observations, the present results indicates that upregulated expression of HSP in the aftermath of acute injury may be an interesting avenue for early protection of spinal motoneurons.
DOI: 10.7284/123307
title: Meteorological Station data collected during research cruise SP1614 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231343.v1
title: Dataset for: Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase (CaMKK) Exacerbates Impairment of Endothelial Cell and Blood-Brain Barrier after Stroke

description: Brain microvascular endothelial cells play an essential role in maintaining blood-brain barrier (BBB) integrity, and disruption of the BBB aggravates the ischemic injury. CaMKK (α and β) is a major kinase activated by elevated intracellular calcium. Previously, we demonstrated that inhibition of CaMKK exacerbated outcomes, conversely, overexpression reduced brain injury after stroke in mice. Interestingly, CaMKK has been shown to activate a key endothelial protector, Sirtuin 1 (SIRT1). We hypothesized that CaMKK protects brain endothelial cells via SIRT1 activation after stroke. In this study, Oxygen-Glucose Deprivation (OGD) was performed in human brain microvascular endothelial cells. Stroke was induced by middle cerebral artery occlusion (MCAO) in male mice. Knockdown of CaMKK β using siRNA increased cell death following OGD. Inhibition of CaMKK β by STO-609 significantly and selectively down-regulated levels of phosphorylated SIRT1 after OGD. Changes in the downstream targets of SIRT1 were observed following STO-609 treatment. The effect of STO-609 on cell viability after OGD was absent when SIRT1 was concurrently inhibited. We also demonstrated that STO-609 increased endothelial expression of the pro-inflammatory proteins ICAM-1 and VCAM-1 and inhibition of CaMKK exacerbated OGD-induced leukocyte-endothelial adhesion. Finally, intracerebroventricular injection of STO-609 exacerbated endothelial apoptosis and reduced BBB integrity after 24-hour reperfusion following MCAO in vivo. Collectively, these results demonstrated that CaMKK inhibition reduced endothelial cell viability, exacerbated inflammatory responses and aggravated BBB impairment after ischemia. CaMKK activation may attenuate ischemic brain injury via protection of the microvascular system and a reduction in the infiltration of pro-inflammatory factors.
DOI: 10.6084/m9.figshare.7231307
title: 5 DO at the end of the experiment (experiment with ramets)

description: DO at the end of the experiment (experiment with ramets)
DOI: 10.6084/m9.figshare.7231310
title: 1 Soil ORP ( experiment with ramets )

description: Soil ORP ( experiment with ramets )
DOI: 10.7284/123306
title: Winch data collected during research cruise SP1614 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231307.v1
title: 5 DO at the end of the experiment (experiment with ramets)

description: DO at the end of the experiment (experiment with ramets)
DOI: 10.6084/m9.figshare.7231310.v1
title: 1 Soil ORP ( experiment with ramets )

description: Soil ORP ( experiment with ramets )
DOI: 10.6084/m9.figshare.7231298
title: 4 plant nitrogen concentration

description: plant nitrogen concentration
DOI: 10.6084/m9.figshare.7231301
title: 4 plant phosphorus concentration

description: plant phosphorus concentration
DOI: 10.7284/123321
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1616 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231292
title: 3 Specific root length

description: Specific root length
DOI: 10.6084/m9.figshare.7231289
title: 3 DO

description: DO (experiment with ramets)
DOI: 10.7284/123325
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1616 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231286
title: 2 the ratio of root biomass to above-ground biomass

description: the ratio of root biomass to above-ground biomass
DOI: 10.6084/m9.figshare.7231289.v1
title: 3 DO

description: DO (experiment with ramets)
DOI: 10.6084/m9.figshare.7231286.v1
title: 2 the ratio of root biomass to above-ground biomass

description: the ratio of root biomass to above-ground biomass
DOI: 10.7284/123326
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1616 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231259
title: 2 Relative growth rate

description: Relative growth rate
DOI: 10.6084/m9.figshare.7231280
title: 2 Root diameter

description: Root diameter
DOI: 10.6084/m9.figshare.7231259.v1
title: 2 Relative growth rate

description: Relative growth rate
DOI: 10.6084/m9.figshare.7231280.v2
title: 2 Root diameter

description: Root diameter
DOI: 10.6084/m9.figshare.7231250
title: 2 Biomass accumulation

description: Biomass accumulation
DOI: 10.6084/m9.figshare.7231253
title: 2 Mean root length

description: Mean root length
DOI: 10.6084/m9.figshare.7231280.v1
title: 2 Root diameter

description: Root diameter
DOI: 10.7284/123327
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1616 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231250.v1
title: 2 Biomass accumulation

description: Biomass accumulation
DOI: 10.6084/m9.figshare.7231253.v2
title: 2 Mean root length

description: Mean root length
DOI: 10.6084/m9.figshare.7231244

description: Soil ORP ( experiment with ramets )
DOI: 10.6084/m9.figshare.7231253.v1
title: 2 Mean root length

description: Mean root length
DOI: 10.7284/123328
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1616 using a Furuno GP-150 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231217
title: 0 Turbidity

description: Turbidity ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231217.v1
title: 0 Turbidity

description: Turbidity ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231244.v1
title: 1 Soil ORP

description: Soil ORP ( experiment with ramets )
DOI: 10.7284/123324
title: Gyrocompass data collected during research cruise SP1616 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231214
title: 0 Soil ORP

description: Soil ORP ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231208
title: 0 pH

description: pH ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231214.v2
title: 0 Soil ORP

description: Soil ORP ( experiment without ramets )
DOI: 10.7284/123323
title: Meteorological Station data collected during research cruise SP1616 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231214.v1
title: 0 Soil ORP

description: Soil ORP ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231205
title: 0 DO

description: DO ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231208.v1
title: 0 pH

description: pH ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231202
title: Citrine Thermal Conductivity Data

description: Thermal conductivity of 872 compounds measured experimentally and retrieved from Citrine database from various references. The reported values are measured at various temperatures of which 295 are at room temperature.<br>Available as Monty Encoder encoded JSON and as CSV. Recommended access method for these particular files is with the matminer Python package using the datasets module.<br><br>Note on citations: If you found this dataset useful and would like to cite it in your work, please be sure to cite Citrine Informatics and their citrination client rather than or in addition to this page.<br>
DOI: 10.7284/123322
title: Winch data collected during research cruise SP1616 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231205.v2
title: 0 DO

description: DO ( experiment without ramets )
DOI: 10.7284/123329
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1617 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231199
title: 0 DCD

description: DCD ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231205.v1
title: 0 DO

description: DO ( experiment without ramets )
DOI: 10.6084/m9.figshare.7231199.v1
title: 0 DCD

description: DCD ( experiment without ramets )
DOI: 10.7284/124439
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SP1617 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123334
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1617 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123335
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1617 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123336
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1617 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123337
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1617 using a Furuno GP-150 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123333
title: Gyrocompass data collected during research cruise SP1617 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123332
title: Meteorological Station data collected during research cruise SP1617 using a SIO MET-System instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123330
title: Singlebeam Echosounder data collected during research cruise SP1617 using a Knudsen 320B/R instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231031
title: Clock-Drawing_healthyaging_fMRIData

description: Functional MRI data for a healthy aging cohort completing the clock-drawing test
DOI: 10.7284/123331
title: Winch data collected during research cruise SP1617 using a Markey DEYSH-3 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7231031.v1
title: Clock-Drawing_healthyaging_fMRIData

description: Functional MRI data for a healthy aging cohort completing the clock-drawing test
DOI: 10.6084/m9.figshare.7231010
title: Effects of Neutering Across Breeds and Mixed Breeds

description: Datasets used to study the effects of neutering (including spaying) in increasing the incidence of joint disorders and cancers in Australian Cattle Dogs, Australian Shepherds, Beagles, Bernese Mountain Dogs, Border Collies, Boston Terriers, Boxers, Bulldogs, Cavalier King Charles Spaniels, Chihuahuas, Cocker Spaniels, Collies, Corgis, Dachshunds, Doberman Pinschers, English Springer Spaniels, German Shepherds, Golden Retrievers, Great Danes, Irish Wolfhounds, Jack Russell Terriers, Labrador Retrievers, Malteses, Miniature Schnauzers, Pomeranians, Poodles (3 varieties), Pugs, Rottweilers, Saint Bernards, Shetland Sheepdogs, Shih Tzus, West Highland White Terriers, Yorkshire Terriers, and 5 weight categories of mixed breed dogs: small (&lt;10kg), medium (10-19kg), standard (20-29kg), large (30-39kg), and giant (40+kg). Veterinary hospital records from the University of California, Davis were examined for dogs ranging from ages 1 to 11 for the effects of neutering during the specified age ranges: before 6 mo., and during 6-11 mo., during 1 year and in years 2 through 8. The diseases examined were hip dysplasia, CCL tear, elbow dysplasia, lymphosarcoma, mast cell tumor, hemangiosarcoma, osteosarcoma, mammary cancer, pyometra, and urinary incontinence.<br>
DOI: 10.7284/123338
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise SP1618 using a Hawaii UHDAS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/124440
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise SP1618 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123342
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1618 using a Garmin GPS-17HVS instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123343
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1618 using a Ashtech ADU2 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/123344
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1618 using a Furuno GP-90D instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7230824
title: Medicinal Plants used by indigenous population in Mexico for the treatment of Type II Diabetes Mellitus ( DM-T2 )

description: Data materialsMedicinal Plants used by indigenous population in Mexico for the treatment of Type II Diabetes Mellitus ( DM-T2 ) Aidé Avendaño Gómez, Gil Alfonso Magos Guerrero, Arciniegas Arciniegas Amira, Romo de Vivar Romo Alfonso. Includes: Catalog and herbarium information. Fidelity Index Table of 45 medicinal plants, Abstract pf bibliographical research. <b></b><i></i><sub></sub><sup></sup><br><sup><b></b><i></i><sub></sub><br></sup><b></b>
DOI: 10.6084/m9.figshare.7230827
title: Confusion in Code Reviews: Reasons, Impacts and Coping Strategies

description: This is the dataset accompanying the paper "Confusion in Code Reviews: Reasons, Impacts and Coping Strategies" to be published at The 26th IEEE International Conference on Software Analysis, Evolution, and Reengineering (SANER'2019).
DOI: 10.6084/m9.figshare.7230827.v1
title: Confusion in Code Reviews: Reasons, Impacts and Coping Strategies

description: This is the dataset accompanying the paper "Confusion in Code Reviews: Reasons, Impacts and Coping Strategies" to be published at The 26th IEEE International Conference on Software Analysis, Evolution, and Reengineering (SANER'2019).
DOI: 10.7284/123345
title: GNSS (Global Navigation Satellite System) data collected during research cruise SP1618 using a Furuno GP-150 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7230788
title: Glass Ternary Landolt Data

description: Metallic glass formation dataset for ternary alloys, collected from the "Nonequilibrium Phase Diagrams of Ternary Amorphous Alloys,’ a volume of the Landolt– Börnstein collection. This dataset contains experimental measurements of whether it is possible to form a glass using a variety of processing techniques at thousands of compositions from hundreds of ternary systems. The processing techniques are designated in the "processing" column.<br><br>There are originally 7191 experiments in this dataset, will be reduced to 6203 after deduplicated, and will be further reduced to 6118 if combining multiple data for one composition. There are originally 6780 melt-spinning experiments in this dataset, will be reduced to 5800 if deduplicated, and will be further reduced to 5736 if combining multiple experimental data for one composition.<br><br>Available as Monty Encoder encoded JSON and as CSV. Recommended access method for these particular files is with the matminer Python package using the datasets module.<br><br>Note on citations: If you found this dataset useful and would like to cite it in your work, please be sure to cite its original sources below rather than or in addition to this page.<br>Dataset sourced from: Y. Kawazoe, T. Masumoto, A.-P. Tsai, J.-Z. Yu, T. Aihara Jr. (1997) Y. Kawazoe, J.-Z. Yu, A.-P. Tsai, T. Masumoto (ed.) SpringerMaterials <strong>Nonequilibrium Phase Diagrams of Ternary Amorphous Alloys · 1 Introduction </strong> Landolt-Börnstein - Group III Condensed Matter 37A (Nonequilibrium Phase Diagrams of Ternary Amorphous Alloys) https://materials.springer.com/lb/docs/sm_lbs_978-3-540-47679-5_2 10.1007/10510374_2 (Springer-Verlag Berlin Heidelberg © 1997) Accessed: 20-10-2018 <br>Dataset provided for comparison to work in the following paper: <br><br>A general-purpose machine learning framework for predicting properties of inorganic materials Logan Ward, Ankit Agrawal, Alok Choudhary & Christopher Wolverton <i>npj Computational Materials</i> <b>volume 2</b>, Article number: 16028 (2016)<br>
DOI: 10.7284/123341
title: Gyrocompass data collected during research cruise SP1618 using a Furuno Furuno SC-30 instrument system onboard the platform RV Robert Gordon Sproul

description: Original (unprocessed) data collected during a Field_expedition