cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12884798
title: Supporting information for the book: Word Association Thematic Analysis: A Social Media Text Exploration Strategy

description: This spreadsheet is used in the book: Word Association Thematic Analysis: A Social Media Text Exploration Strategy.
DOI: 10.6084/m9.figshare.12884798.v1
title: Supporting information for the book: Word Association Thematic Analysis: A Social Media Text Exploration Strategy

description: This spreadsheet is used in the book: Word Association Thematic Analysis: A Social Media Text Exploration Strategy.
DOI: 10.6084/m9.figshare.7731629
title: Bug Analysis Report

description: The full set of bug reports that were analyzed in the paper "How Bad Can a Bug Get? An Empirical analysis of software failures in the OpenStack cloud computing platform" (ESEC/FSE '19)<br><br>Please, cite the following paper if you use the dataset:<br><pre>@inproceedings{cotroneo2019bad,</pre><pre>title={How bad can a bug get? an empirical analysis of software failures in the OpenStack cloud computing platform},</pre><pre>author={Cotroneo, Domenico and De Simone, Luigi and Liguori, Pietro and Natella, Roberto and Bidokhti, Nematollah},</pre><pre>booktitle={Proceedings of the 2019 27th ACM Joint Meeting on European Software Engineering Conference and Symposium on the Foundations of Software Engineering},</pre><pre>pages={200--211},</pre><pre>year={2019} }</pre>
DOI: 10.7284/127382
title: Fluorometer data collected during research cruise AR23-01 using a WET Labs WETStar instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7731629.v1
title: Bug Analysis Report

description: The full set of bug reports that were analyzed in the paper "How Bad Can a Bug Get? An Empirical analysis of software failures in the OpenStack cloud computing platform" (ESEC/FSE '19)<br><br>Please, cite the following paper if you use the dataset:<br><pre>@inproceedings{cotroneo2019bad,</pre><pre>title={How bad can a bug get? an empirical analysis of software failures in the OpenStack cloud computing platform},</pre><pre>author={Cotroneo, Domenico and De Simone, Luigi and Liguori, Pietro and Natella, Roberto and Bidokhti, Nematollah},</pre><pre>booktitle={Proceedings of the 2019 27th ACM Joint Meeting on European Software Engineering Conference and Symposium on the Foundations of Software Engineering},</pre><pre>pages={200--211},</pre><pre>year={2019} }</pre>
DOI: 10.7284/127399
title: GNSS (Global Navigation Satellite System) data collected during research cruise AR23-01 using a C&C C-Nav 3050 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/127411
title: Gravimeter data collected during research cruise AR23-01 using a Bell BGM-3 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/127383
title: Gyrocompass data collected during research cruise AR23-01 using a Sperry NAVIGAT X MK 1 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/127394
title: Multibeam Echosounder data collected during research cruise AR23-01 using a Kongsberg EM122 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7731560
title: Antivenom effect on lymphatic absorption and pharmacokinetics of coral snake venom using a large animal model

description: <b>Context:</b> Historically, administration and dosing of antivenom (AV) have been guided primarily by physician judgment because of incomplete understanding of the envenomation process. As demonstrated previously, lymphatic absorption plays a major role in the availability and pharmacokinetics (PK) of coral snake venom injected subcutaneously, which suggests that absorption from subcutaneous tissue is the limiting step for venom bioavailability, supporting the notion that the bite site is an ongoing venom depot. This feature may underlie the recurrence phenomena reported in viperid envenomation that appear to result from a mismatch between venom and AV PK. The role of lymphatic absorption in neutralization of venom by AV administered intravenously remains unclear. <b>Methods:</b> The effect of AV on systemic bioavailability and neutralization of <i>Micrurus fulvius</i> venom was assessed using a central lymph-cannulated sheep model. Venom was administered by subcutaneous injection in eight sheep, four with and four without thoracic duct cannulation and drainage. Two hours after venom injection, AV was administered intravenously. Venom and AV concentrations in serum and lymph were determined by ELISA assay from samples collected over a 6-h period and in tissues harvested post-mortem. <b>Results:</b> After AV injection, venom levels in serum fell immediately to undetectable with a subsequent increase in concentration attributable to non-toxic venom proteins. In lymph, AV became detectable 6 min after treatment; venom levels dropped concurrently but remained detectable 4 h later. Post-mortem samples from the venom injection site confirmed the presence of venom near the point of injection. Neither venom nor AV was detected at significant concentrations in major organs or contralateral skin. <b>Conclusions:</b> Intravenous AV immediately neutralizes venom in the bloodstream and can extravasate to neutralize venom absorbed by lymph but this neutralization seems to be slow and incomplete. Residual venom in the inoculation site demonstrates that this site functions as a depot where it is not neutralized by AV, which allows the venom to remain active with slow delivery to the bloodstream for ongoing systemic distribution.
DOI: 10.6084/m9.figshare.7731563
title: Beach Hand Ball.sav

description: Spss data beach handball skin lesions, habits and knoweledge<br>
DOI: 10.7284/127398
title: Multibeam Echosounder data collected during research cruise AR23-01 using a Kongsberg EM710 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/127392
title: Radiometer data collected during research cruise AR23-01 using a Biospherical QSR-2150 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17028/rd.lboro.7731524
title: Supplementary information file for article: 'Verbal count sequence knowledge underpins numeral order processing in children'

description: Supplementary information file for article: 'Verbal count sequence knowledge underpins numeral order processing in children'. Abstract: This dataset is from a study of children's basic numerical skills. Children (aged 6 to 8 years) completed tasks to measure: (1) count sequence knowledge; (2) numeral order processing; (3) Rapid Automatized Naming; and (4) arithmetic. (Article under review.)
DOI: 10.6084/m9.figshare.7731509
title: Carboxylic acids accelerate acidic environment-mediated nanoceria dissolution

description: Ligands that accelerate nanoceria dissolution may greatly affect its fate and effects. This project assessed the carboxylic acid contribution to nanoceria dissolution in aqueous, acidic environments. Nanoceria has commercial and potential therapeutic and energy storage applications. It biotransforms <i>in vivo</i>. Citric acid stabilizes nanoceria during synthesis and in aqueous dispersions. In this study, citrate-stabilized nanoceria dispersions (∼4 nm average primary particle size) were loaded into dialysis cassettes whose membranes passed cerium salts but not nanoceria particles. The cassettes were immersed in iso-osmotic baths containing carboxylic acids at pH 4.5 and 37 °C, or other select agents. Cerium atom material balances were conducted for the cassette and bath by sampling of each chamber and cerium quantitation by ICP-MS. Samples were collected from the cassette for high-resolution transmission electron microscopy observation of nanoceria size. In carboxylic acid solutions, nanoceria dissolution increased bath cerium concentration to &gt;96% of the cerium introduced as nanoceria into the cassette and decreased nanoceria primary particle size in the cassette. In solutions of citric, malic, and lactic acids and the ammonium ion ∼15 nm, ceria agglomerates persisted. In solutions of other carboxylic acids, some select nanoceria agglomerates grew to ∼1 micron. In carboxylic acid solutions, dissolution half-lives were 800–4000 h; in water and horseradish peroxidase they were ≥55,000 h. Extending these findings to <i>in vivo</i> and environmental systems, one expects acidic environments containing carboxylic acids to degrade nanoceria by dissolution; two examples would be phagolysosomes and in the plant rhizosphere.
DOI: 10.6084/m9.figshare.7731536.v1
title: bug_analysis_public.xlsx

description: The full set of bug reports.
DOI: 10.7284/127393
title: Radiometer data collected during research cruise AR23-01 using a Eppley RAD instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.17028/rd.lboro.7731524.v1
title: Supplementary information file for article: 'Verbal count sequence knowledge underpins numeral order processing in children'

description: Supplementary information file for article: 'Verbal count sequence knowledge underpins numeral order processing in children'. Abstract: This dataset is from a study of children's basic numerical skills. Children (aged 6 to 8 years) completed tasks to measure: (1) count sequence knowledge; (2) numeral order processing; (3) Rapid Automatized Naming; and (4) arithmetic. (Article under review.)
DOI: 10.6084/m9.figshare.7731509.v1
title: Carboxylic acids accelerate acidic environment-mediated nanoceria dissolution

description: Ligands that accelerate nanoceria dissolution may greatly affect its fate and effects. This project assessed the carboxylic acid contribution to nanoceria dissolution in aqueous, acidic environments. Nanoceria has commercial and potential therapeutic and energy storage applications. It biotransforms <i>in vivo</i>. Citric acid stabilizes nanoceria during synthesis and in aqueous dispersions. In this study, citrate-stabilized nanoceria dispersions (∼4 nm average primary particle size) were loaded into dialysis cassettes whose membranes passed cerium salts but not nanoceria particles. The cassettes were immersed in iso-osmotic baths containing carboxylic acids at pH 4.5 and 37 °C, or other select agents. Cerium atom material balances were conducted for the cassette and bath by sampling of each chamber and cerium quantitation by ICP-MS. Samples were collected from the cassette for high-resolution transmission electron microscopy observation of nanoceria size. In carboxylic acid solutions, nanoceria dissolution increased bath cerium concentration to &gt;96% of the cerium introduced as nanoceria into the cassette and decreased nanoceria primary particle size in the cassette. In solutions of citric, malic, and lactic acids and the ammonium ion ∼15 nm, ceria agglomerates persisted. In solutions of other carboxylic acids, some select nanoceria agglomerates grew to ∼1 micron. In carboxylic acid solutions, dissolution half-lives were 800–4000 h; in water and horseradish peroxidase they were ≥55,000 h. Extending these findings to <i>in vivo</i> and environmental systems, one expects acidic environments containing carboxylic acids to degrade nanoceria by dissolution; two examples would be phagolysosomes and in the plant rhizosphere.
DOI: 10.6084/m9.figshare.7731470
title: An evaluation of metabolite profiling of six drugs using dried blood spot

description: Dry blood spot (DBS) analysis has been extensively used for the quantitative analysis of drugs by mass spectrometry; however, utilization of DBS for qualitative metabolite profiling has been very limited.In the present study, we investigated the use of DBS for metabolite profiling of genistein, carbamazepine, losartan, sunitinib, sildenafil and zoniporide representing a range of Phase I and Phase II biotransformations following oral and intravenous dosing to rats. Plasma and DBS were collected for PK and metabolite profiling. Analyte extraction recovery from DBS was optimized using the parent compound and metabolite standard. Rat DBS metabolite profiles from all six compounds were similar to plasma metabolite profiles, however Phase II metabolites appeared to be extracted less efficiently from DBS compared to plasma, and compounds that were unstable in blood showed different metabolite profiles.In summary, this study showed that in addition to PK bioanalytical analysis, DBS samples may also be utilized for metabolite profiling and a comparison of plasma and DBS metabolite profiling can also provide partitioning/association of major circulating metabolites compared to the parent drug even in the absence of a metabolite standard. Dry blood spot (DBS) analysis has been extensively used for the quantitative analysis of drugs by mass spectrometry; however, utilization of DBS for qualitative metabolite profiling has been very limited. In the present study, we investigated the use of DBS for metabolite profiling of genistein, carbamazepine, losartan, sunitinib, sildenafil and zoniporide representing a range of Phase I and Phase II biotransformations following oral and intravenous dosing to rats. Plasma and DBS were collected for PK and metabolite profiling. Analyte extraction recovery from DBS was optimized using the parent compound and metabolite standard. Rat DBS metabolite profiles from all six compounds were similar to plasma metabolite profiles, however Phase II metabolites appeared to be extracted less efficiently from DBS compared to plasma, and compounds that were unstable in blood showed different metabolite profiles. In summary, this study showed that in addition to PK bioanalytical analysis, DBS samples may also be utilized for metabolite profiling and a comparison of plasma and DBS metabolite profiling can also provide partitioning/association of major circulating metabolites compared to the parent drug even in the absence of a metabolite standard.
DOI: 10.6084/m9.figshare.7731470.v1
title: An evaluation of metabolite profiling of six drugs using dried blood spot

description: Dry blood spot (DBS) analysis has been extensively used for the quantitative analysis of drugs by mass spectrometry; however, utilization of DBS for qualitative metabolite profiling has been very limited.In the present study, we investigated the use of DBS for metabolite profiling of genistein, carbamazepine, losartan, sunitinib, sildenafil and zoniporide representing a range of Phase I and Phase II biotransformations following oral and intravenous dosing to rats. Plasma and DBS were collected for PK and metabolite profiling. Analyte extraction recovery from DBS was optimized using the parent compound and metabolite standard. Rat DBS metabolite profiles from all six compounds were similar to plasma metabolite profiles, however Phase II metabolites appeared to be extracted less efficiently from DBS compared to plasma, and compounds that were unstable in blood showed different metabolite profiles.In summary, this study showed that in addition to PK bioanalytical analysis, DBS samples may also be utilized for metabolite profiling and a comparison of plasma and DBS metabolite profiling can also provide partitioning/association of major circulating metabolites compared to the parent drug even in the absence of a metabolite standard. Dry blood spot (DBS) analysis has been extensively used for the quantitative analysis of drugs by mass spectrometry; however, utilization of DBS for qualitative metabolite profiling has been very limited. In the present study, we investigated the use of DBS for metabolite profiling of genistein, carbamazepine, losartan, sunitinib, sildenafil and zoniporide representing a range of Phase I and Phase II biotransformations following oral and intravenous dosing to rats. Plasma and DBS were collected for PK and metabolite profiling. Analyte extraction recovery from DBS was optimized using the parent compound and metabolite standard. Rat DBS metabolite profiles from all six compounds were similar to plasma metabolite profiles, however Phase II metabolites appeared to be extracted less efficiently from DBS compared to plasma, and compounds that were unstable in blood showed different metabolite profiles. In summary, this study showed that in addition to PK bioanalytical analysis, DBS samples may also be utilized for metabolite profiling and a comparison of plasma and DBS metabolite profiling can also provide partitioning/association of major circulating metabolites compared to the parent drug even in the absence of a metabolite standard.
DOI: 10.7284/127389
title: Singlebeam Echosounder data collected during research cruise AR23-01 using a Knudsen 3260 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/127381
title: Speedlog data collected during research cruise AR23-01 using a JRC JLN-550 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/127388
title: SSV (Sound Speed Velocimeter) data collected during research cruise AR23-01 using a AML SmartX P1S2 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7731317
title: Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

description: The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWCNTs delivered to the lungs of p53 heterozygous (p53<sup>+/−</sup>) mice has not been investigated. We hypothesized that p53<sup>+/−</sup> mice would be susceptible to lung tumor development after exposure to either tangled (t-) or rod-like (r-) MWCNTs. Wild-type (p53<sup>+/+</sup>) or p53<sup>+/−</sup> mice were exposed to MWCNTs (1 mg/kg) via oropharyngeal aspiration weekly over four consecutive weeks and evaluated for cellular and pathologic outcomes 11-months post-initial exposure. No lung or pleural tumors were observed in p53<sup>+/+</sup> or p53<sup>+/−</sup> mice exposed to either t- or rMWCNTs. In comparison to tMWCNTs, the rMWCNTs induced the formation of larger granulomas, a greater number of lymphoid aggregates and greater epithelial cell hyperplasia in terminal bronchioles in both p53<sup>+/−</sup> and p53<sup>+/+</sup> mice. A constitutively larger area of CD45R<sup>+</sup>/CD3<sup>+</sup> lymphoid tissue was observed in p53<sup>+/−</sup> mice compared to p53<sup>+/+</sup> mice. Importantly, p53<sup>+/−</sup> mice had larger granulomas induced by rMWCNTs as compared to p53<sup>+/+</sup> mice. These findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation.
DOI: 10.7284/127380
title: Water Temperature data collected during research cruise AR23-01 using a Sea-Bird SBE-48 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7731317.v1
title: Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

description: The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWCNTs delivered to the lungs of p53 heterozygous (p53<sup>+/−</sup>) mice has not been investigated. We hypothesized that p53<sup>+/−</sup> mice would be susceptible to lung tumor development after exposure to either tangled (t-) or rod-like (r-) MWCNTs. Wild-type (p53<sup>+/+</sup>) or p53<sup>+/−</sup> mice were exposed to MWCNTs (1 mg/kg) via oropharyngeal aspiration weekly over four consecutive weeks and evaluated for cellular and pathologic outcomes 11-months post-initial exposure. No lung or pleural tumors were observed in p53<sup>+/+</sup> or p53<sup>+/−</sup> mice exposed to either t- or rMWCNTs. In comparison to tMWCNTs, the rMWCNTs induced the formation of larger granulomas, a greater number of lymphoid aggregates and greater epithelial cell hyperplasia in terminal bronchioles in both p53<sup>+/−</sup> and p53<sup>+/+</sup> mice. A constitutively larger area of CD45R<sup>+</sup>/CD3<sup>+</sup> lymphoid tissue was observed in p53<sup>+/−</sup> mice compared to p53<sup>+/+</sup> mice. Importantly, p53<sup>+/−</sup> mice had larger granulomas induced by rMWCNTs as compared to p53<sup>+/+</sup> mice. These findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation.
DOI: 10.7284/127377
title: TSG (Thermosalinograph) data collected during research cruise AR23-01 using a Sea-Bird SBE-45 instrument system onboard the platform RV Neil Armstrong

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7731236
title: Diagnostic value of the urine TB-LAM assay in ambulatory HIV-positive patients with CD4 below 200 cells/µL in two low-resource settings: a prospective observational study.

description: Dataset from a prospective study that aimed to evaluate the diagnostic yield of including LAM in the TB diagnostic algorithms in HIV-positive ambulatory patients with CD4&lt;200 cells/µL in two low-resource settings. The study also assessed the risk of mortality in LAM-positive patients who were not diagnosed using other diagnostic tools and not treated for TB. <br>