cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/45r6ps4r68.2
title: Data for labor market concentration using Lightcast (formerly Burning Glass Technologies)

description: Using the job vacancy data from Lightcast from 2007Q1 to 2021Q2 (2008 and 2009 data are not available), we measure labor market concentration by using the Herfindahl Hirschman Index (HHI) in labor markets defined by the occupation (6-digit SOC), commuting zone, and quarterly level. The HHI is calculated based on the share of vacancies of all the firms that post vacancies in that market. It is the sum of vacancies by a given firm in a given market and year-quarter divided by the total vacancies of all firms posted on the website in that market and year-quarter. Data includes information on year-quarter, 6-digit SOC, commuting Zone, lower bound HHI, and higher bound HHI.
DOI: 10.17632/hph8nmzw6m.1
title: LINF_360007700

description: eukaryotic initiation factor 3 subunit L | eIF3L
Leishmania infantum (strain JPCM5)
DOI: 10.17632/x32vsrfnxz.1
title: LINF_360008300

description: dolicholphosphate-mannose synthase
Leishmania infantum (strain JPCM5)
DOI: 10.17632/pr9vxg94gd.3
title: Data for Sun et al. (2024) 'The Role of Acantharia in Southern Ocean Strontium Cycling and Carbon Export: Insights from Dissolved Strontium Concentrations and Seasonal Flux Patterns'

description: This record presents the strontium (Sr) data used in the paper 'The Role of Acantharia in Southern Ocean Strontium Cycling and Carbon Export: Insights from Dissolved Strontium Concentrations and Seasonal Flux Patterns', Sun et al. (2024). All methods for the dataset are thoroughly documented and cross-referenced in the paper. 

Introduction: The dataset examines how Acantharia, marine protists with celestite (SrSO4) skeletons, influence strontium (Sr) and carbon cycling in the Southern Ocean. Acantharia utilize surface Sr to build skeletons and release it upon death, significantly impacting Sr distribution. Their cysts, also celestite-based, act as effective ballast for particulate organic carbon (POC). Analysis of dissolved and particulate Sr concentrations indicates Acantharia's dominant role in Sr cycles, with seasonal flux variations, particularly intense in January/February, likely linked to increased productivity and ocean temperatures during that period.

Sampling Sites: Dissolved and particulate Sr samples were collected in the Australian sector of the Southern Ocean during R/V Investigator voyages IN2018_V01 and IN2020_V08. The IN2018_V01 voyage was conducted between 10 January and 22 February 2018, along the SR3 transect (44°S – 66°S, 140°E – 146°E). The IN2020_V08 voyage was carried out between 4 December 2020, and 15 January 2021, with sampling conducted at three primary sites. Samples were collected at three primary sites: the Southern Ocean Time Series (SOTS) site (47°S, 141°E), and two southern sites (SS1 and SS2) located within a polar bloom at approximately 55°S, 138°E, and 58°S, 141°E, respectively. Seasonal surface and deep ocean mooring samples are archived samples collected at the SOTS site from long-term SOTS moorings and measured for Sr from selected years.

Sampling Methodology: Dissolved Sr samples were collected using CTD rosettes at various depths. Particulate Sr samples were obtained using McLane pumps, focusing on subsurface waters to estimate the standing stock of Acantharia. Surface mooring samples were collected using a Remote Access Sampler (RAS-599, McLane Labs) and filtered through a 1mm plastic mesh on the sample inlet. The deep ocean mooring samples were collected from 1000 m sediment traps. The cups were buffered with SrCl2 prior to deployment to prevent the dissolution of Acantharia. After recovery, the cups were separated into &gt;1mm and &lt;1mm fractions. The &gt;1mm fraction was archived in buffered seawater, while the &lt;1mm fraction was dried and homogenized into powders.

Data Analysis: All the samples were digested and/or diluted in 2% HNO3 and measured on the ICP-OES for Sr concentrations. The results were normalized to a salinity of 35. Uncertainty in Sr measurements was assessed based on the average one standard deviation of triplicate measurements across the dataset.
DOI: 10.17632/gn73p8t9fb
title: Tectonic Setting and Evolution of the Kangguer Ocean: New Constraints from Structural and Geochemical Analyses of the Late Paleozoic Kangguer mélange Belt in Eastern Tianshan, NW China

description: Supporting Information for “Tectonic Setting and Evolution of the Kangguer Ocean: New Constraints from Structural and Geochemical Analyses of the Late Paleozoic Kangguer mélange Belt in Eastern Tianshan, NW China”
DOI: 10.17632/z8vrr5hk33.1
title: Exploring Factors Driving Customer Retention and Advocacy in Food Delivery Apps – Data from a Public University in Vietnam

description: The research period spanned from September 2022 to January 2023 and resulted in 346 usable responses. The findings offer fresh insights into the university students' use of FDAs, a transforming digital technology in the food and beverage industry. The data set holds value for service providers, SMEs, and sellers on these platforms to better understand their target audience and attract more users, particularly university students. Furthermore, the dataset provides a foundation for further comparative studies to be conducted at other universities or countries.
DOI: 10.17632/gn73p8t9fb.1
title: Tectonic Setting and Evolution of the Kangguer Ocean: New Constraints from Structural and Geochemical Analyses of the Late Paleozoic Kangguer mélange Belt in Eastern Tianshan, NW China

description: Supporting Information for “Tectonic Setting and Evolution of the Kangguer Ocean: New Constraints from Structural and Geochemical Analyses of the Late Paleozoic Kangguer mélange Belt in Eastern Tianshan, NW China”
DOI: 10.17632/xh2mkrg6cv.1
title: Metagenomic communities inhabiting Phragmites australis litter

description: In this study, the intermittent lake is taken up as a model for changes in water availability and how they affect the functional microbial communities decomposing Phragmites australis litter. The original material (source material) was exposed to decomposition at a predominately wet site (wet; 45°43'38.30" N, 14°24'16,59" E) or dry site (dry; 45°43'38.29" N, 14°24'16,72" E) for a duration of 45 days.
The overall aim of our study was to evaluate the effect of different conditions due to fluctuating water levels on the decomposition of P. australis litter. To predict litter decomposition dynamics in intermittent lakes, it is critical to understand how the functional microbial communities (present in the decomposing leaves) change under different habitat conditions. First, we hypothesized that functional communities from fresh leaves would change due to the start of the decomposition processes. Second, we hypothesized that the response of communities in different habitats would differ relative to the submergence level, showing differences in the metabolic processes. Our last hypothesis was that changes at the level of functional genes would be more pronounced in bacterial than in fungal functional communities. To evaluate our hypotheses, we analyzed functional microbial communities in fresh P. australis leaves and leaves decomposing in either wet or dry habitats that are characterized by different flooding patterns.
DOI: 10.15468/dl.jyjwgs
title: Occurrence Download

description: A dataset containing 228 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "RecordedBy is one of (stefanka, Salza Palpurina)",
 "TaxonKey is Lepidoptera"
 ]
}

 The dataset includes 228 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004400-250117142028555/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/f7dwpnk986.1
title: LINF_360009700

description: protein of unknown function - conserved
Leishmania infantum (strain JPCM5)
DOI: 10.17632/7nrw4dx79c.1
title: LINF_360008800

description: Integral membrane protein DUF106
Leishmania infantum (strain JPCM5)
DOI: 10.17632/bfs2h2zhgf.1
title: Nickel isotopes in olivine from magmatic Ni-Cu deposits

description: Nickel isotopic compositions in olivine, bulk sulfide, and sulfide minerals from the East Tianshan magmatic Ni-Cu sulfide deposits
DOI: 10.17632/49tbjg48dx
title: LDHU3_19.0590

description: Putative ribonuclease Inhibitor; Leishmania donovani (HU3 strain)
DOI: 10.17632/49tbjg48dx.1
title: LDHU3_19.0590

description: Putative ribonuclease Inhibitor; Leishmania donovani (HU3 strain)
DOI: 10.6084/m9.figshare.22700272.v1
title: Analysis of non-targeted serum metabolomics in patients with chronic kidney disease and hyperuricemia

description: Hyperuricemia (HUA) is a common complication of chronic kidney disease (CKD). Conversely, HUA can promote the disease progression of CKD. However, the molecular mechanism of HUA in CKD development remains unclear. In the present study, we applied ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze the serum metabolite profiling of 47 HUA patients, 41 non-hyperuricemic CKD (NUA-CKD) patients, and 51 CKD and HUA (HUA-CKD) patients, and then subjected to multivariate statistical analysis, metabolic pathway analysis and diagnostic performance evaluation. Metabolic profiling of serums showed that 40 differential metabolites (fold-change threshold (FC) &gt; 1.5 or&lt;2/3, variable importance in projection (VIP) &gt; 1, and <i>p</i> &lt; 0.05) were screened in HUA-CKD and HUA patients, and 24 differential metabolites (FC &gt; 1.2 or&lt;0.83, VIP&gt;1, and <i>p</i> &lt; 0.05) were screened in HUA-CKD and NUA-CKD patients. According to the analysis of metabolic pathways, significant changes existed in three metabolic pathways (compared with the HUA group) and two metabolic pathways (compared with the HUA-CKD group) in HUA-CKD patients. Glycerophospholipid metabolism was a significant pathway in HUA-CKD. Our findings show that the metabolic disorder in HUA-CKD patients was more serious than that in NUA-CKD or HUA patients. A theoretical basis is provided for HUA to accelerate CKD progress.
DOI: 10.17632/2zp3g59wzj
title: LDHU3_19.0580

description: Paraflagellar component 15 | PFC15; Leishmania donovani (HU3 strain)
DOI: 10.17632/2zp3g59wzj.1
title: LDHU3_19.0580

description: Paraflagellar component 15 | PFC15; Leishmania donovani (HU3 strain)
DOI: 10.6084/m9.figshare.21939473
title: 4-methylthiobutyl isothiocyanate synergize the antiproliferative and pro-apoptotic effects of paclitaxel in human breast cancer cells

description: Multidrug resistance (MDR) is considered as a major obstacle in achieving an effective treatment of breast cancer. Paclitaxel has been used to treat cancers of the cervical, breast, ovarian and brain but MDR limits its therapeutic potential. Phytochemicals have received much interest in recent decades especially in combination approaches to tackle MDR due to their negligible harm to healthy cells and synergistic potential. Considering this notion, the present study aimed at investigating the synergistic activity of 4-MTBITC and PTX against a panel of breast cancer cells. Our results revealed that the combination had a significant antiproliferative activity against <i>T</i>-47D cells. Mechanistic studies revealed that 4-MTBITC and PTX also promoted the production of reactive oxygen species (ROS) and reduced mitochondrial membrane potential. In the presence of 4-MTBITC- PTX, <i>T</i>-47D cells were found to be arrested in the G<sub>2</sub>/M phase which also confirmed the enhancement of late apoptotic cell population in the flow cytometer analysis. In western blot experiment, the combination had a significant decrease in Bcl-xl protein level, whereas a higher level of p53, cleaved caspase-3, and cleaved caspase-9 proteins compared to individual treatment in <i>T</i>-47D cells. The RT-qPCR analysis also showed that the combination had significant upregulation in the gene expression of p53, cytochrome-c, Apaf-1 and downregulation in the expression of Bcl-2 gene in T-47D cells. Hence, all the results showed that a combination of 4-MTBITC-PTX significantly enhanced the apoptosis pathway in the T-47D cell line which indicates its clinical application for the treatment of breast cancer. <b>Abbreviations:</b> Apaf-1: Apoptotic protease activating factor 1; AO/EB: Acridine orange/ethidium bromide; Bcl-2: B-cell lymphoma 2; CI: Combination Index; Cyt-c: Cytochrome c; CO<sub>2</sub>: Carbon dioxide; DCFH-DA 2,7-Dichloroflourescein diacetate; DMEM: Dulbecco’s modified Eagle’s medium; ELISA: Enzyme-linked immunosorbent assay; EA: Early apoptosis; EDTA: Ethylenediaminetetraacetic acid; L929: Normal mouse fibroblast cells; LA: Late apoptosis; L: Live; 4-MTBITC: 4-methylthiobutyl isothiocyanate; MCF-7: Human breast cancer cells; MDA-MB-231: Human triple negative breast cancer cells; MMP: Mitochondria membrane potential; MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide; NCCS: National Centre for Cell Science; N: Necrotic; PTX Paclitaxel; PVDF: Polyvinylidene fluoride; PAGE: Polyacrylamide gel electrophoresis; PBS: Phosphate-buffered saline; RPMI-1640: Roswell Park Memorial Institute Medium- 1640; RT-qPCR: Quantitative real-time polymerase chain reaction; ROS: Reactive oxygen species; Rh-123: Rhodamine123; g Relative centrifugal force; SDS: Sodium dodecyl sulphate; SEM: Scanning electron microscopy; <i>T</i>-47D: Human estrogen positive breast cancer cells; WB: Western blotting.
DOI: 10.6084/m9.figshare.21939473.v1
title: 4-methylthiobutyl isothiocyanate synergize the antiproliferative and pro-apoptotic effects of paclitaxel in human breast cancer cells

description: Multidrug resistance (MDR) is considered as a major obstacle in achieving an effective treatment of breast cancer. Paclitaxel has been used to treat cancers of the cervical, breast, ovarian and brain but MDR limits its therapeutic potential. Phytochemicals have received much interest in recent decades especially in combination approaches to tackle MDR due to their negligible harm to healthy cells and synergistic potential. Considering this notion, the present study aimed at investigating the synergistic activity of 4-MTBITC and PTX against a panel of breast cancer cells. Our results revealed that the combination had a significant antiproliferative activity against <i>T</i>-47D cells. Mechanistic studies revealed that 4-MTBITC and PTX also promoted the production of reactive oxygen species (ROS) and reduced mitochondrial membrane potential. In the presence of 4-MTBITC- PTX, <i>T</i>-47D cells were found to be arrested in the G<sub>2</sub>/M phase which also confirmed the enhancement of late apoptotic cell population in the flow cytometer analysis. In western blot experiment, the combination had a significant decrease in Bcl-xl protein level, whereas a higher level of p53, cleaved caspase-3, and cleaved caspase-9 proteins compared to individual treatment in <i>T</i>-47D cells. The RT-qPCR analysis also showed that the combination had significant upregulation in the gene expression of p53, cytochrome-c, Apaf-1 and downregulation in the expression of Bcl-2 gene in T-47D cells. Hence, all the results showed that a combination of 4-MTBITC-PTX significantly enhanced the apoptosis pathway in the T-47D cell line which indicates its clinical application for the treatment of breast cancer. <b>Abbreviations:</b> Apaf-1: Apoptotic protease activating factor 1; AO/EB: Acridine orange/ethidium bromide; Bcl-2: B-cell lymphoma 2; CI: Combination Index; Cyt-c: Cytochrome c; CO<sub>2</sub>: Carbon dioxide; DCFH-DA 2,7-Dichloroflourescein diacetate; DMEM: Dulbecco’s modified Eagle’s medium; ELISA: Enzyme-linked immunosorbent assay; EA: Early apoptosis; EDTA: Ethylenediaminetetraacetic acid; L929: Normal mouse fibroblast cells; LA: Late apoptosis; L: Live; 4-MTBITC: 4-methylthiobutyl isothiocyanate; MCF-7: Human breast cancer cells; MDA-MB-231: Human triple negative breast cancer cells; MMP: Mitochondria membrane potential; MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide; NCCS: National Centre for Cell Science; N: Necrotic; PTX Paclitaxel; PVDF: Polyvinylidene fluoride; PAGE: Polyacrylamide gel electrophoresis; PBS: Phosphate-buffered saline; RPMI-1640: Roswell Park Memorial Institute Medium- 1640; RT-qPCR: Quantitative real-time polymerase chain reaction; ROS: Reactive oxygen species; Rh-123: Rhodamine123; g Relative centrifugal force; SDS: Sodium dodecyl sulphate; SEM: Scanning electron microscopy; <i>T</i>-47D: Human estrogen positive breast cancer cells; WB: Western blotting.
DOI: 10.6084/m9.figshare.22700272
title: Analysis of non-targeted serum metabolomics in patients with chronic kidney disease and hyperuricemia

description: Hyperuricemia (HUA) is a common complication of chronic kidney disease (CKD). Conversely, HUA can promote the disease progression of CKD. However, the molecular mechanism of HUA in CKD development remains unclear. In the present study, we applied ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze the serum metabolite profiling of 47 HUA patients, 41 non-hyperuricemic CKD (NUA-CKD) patients, and 51 CKD and HUA (HUA-CKD) patients, and then subjected to multivariate statistical analysis, metabolic pathway analysis and diagnostic performance evaluation. Metabolic profiling of serums showed that 40 differential metabolites (fold-change threshold (FC) &gt; 1.5 or&lt;2/3, variable importance in projection (VIP) &gt; 1, and <i>p</i> &lt; 0.05) were screened in HUA-CKD and HUA patients, and 24 differential metabolites (FC &gt; 1.2 or&lt;0.83, VIP&gt;1, and <i>p</i> &lt; 0.05) were screened in HUA-CKD and NUA-CKD patients. According to the analysis of metabolic pathways, significant changes existed in three metabolic pathways (compared with the HUA group) and two metabolic pathways (compared with the HUA-CKD group) in HUA-CKD patients. Glycerophospholipid metabolism was a significant pathway in HUA-CKD. Our findings show that the metabolic disorder in HUA-CKD patients was more serious than that in NUA-CKD or HUA patients. A theoretical basis is provided for HUA to accelerate CKD progress.
DOI: 10.6084/m9.figshare.23101108
title: Causal relationships between autoimmune diseases and celiac disease: A Mendelian randomization analysis

description: The aim of this study was to investigate the causal relationship between autoimmune disorders and celiac disease (CeD) through Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) significantly associated with 13 autoimmune diseases were extracted from the summary statistics of European genome-wide association studies (GWAS), and their effects were examined by Inverse variance-weighted (IVW) in a large European GWAS on CeD. Finally, reverse MR was performed to investigate the causal effects of CeD on autoimmune traits. Following the application of Bonferroni correction for multiple testing, genetically determined seven autoimmune diseases are causally associated with CeD: Crohn’s disease (CD) (OR [95%CI] = 1.156 [1.106 ± 1.208], <i>P</i> = 1.27E–10), primary biliary cholangitis (PBC) (1.229 [1.143 ± 1.321], <i>P</i> = 2.53E–08), primary sclerosing cholangitis (PSC) (1.688 [1.466 ± 1.944], <i>P</i> = 3.56E–13), rheumatoid arthritis (RA) (1.231 [1.154 ± 1.313], <i>P</i> = 2.74E–10), systemic lupus erythematosus (SLE) (1.127 [1.081 ± 1.176], <i>P</i> = 2.59E–08), type 1 diabetes (T1D) (1.41 [1.238 ± 1.606], <i>P</i> = 2.24E–07), and asthma (1.414 [1.137 ± 1.758], <i>P</i> = 1.86E–03). The IVW analysis indicated that CeD increased the risk for seven diseases: CD (1.078 [1.044 ± 1.113], <i>P</i> = 3.71E–06), Graves’ disease (GD) (1.251 [1.127 ± 1.387], <i>P</i> = 2.34E–05), PSC (1.304 [1.227 ± 1.386], <i>P</i> = 8.56E–18), psoriasis (PsO) (1.12 [1.062 ± 1.182], <i>P</i> = 3.38E–05), SLE (1.301[1.22 ± 1.388], <i>P</i> = 1.25E–15), T1D (1.3[1.228 ± 1.376], <i>P</i> = 1.57E–19), and asthma (1.045 [1.024 ± 1.067], <i>P</i> = 1.82E–05). The sensitivity analyses deemed the results reliable without pleiotropy. There are positive genetic correlations between various autoimmune diseases and CeD, and the latter also affects the predisposition to multiple autoimmune disorders in the European population.
DOI: 10.6084/m9.figshare.23101108.v1
title: Causal relationships between autoimmune diseases and celiac disease: A Mendelian randomization analysis

description: The aim of this study was to investigate the causal relationship between autoimmune disorders and celiac disease (CeD) through Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) significantly associated with 13 autoimmune diseases were extracted from the summary statistics of European genome-wide association studies (GWAS), and their effects were examined by Inverse variance-weighted (IVW) in a large European GWAS on CeD. Finally, reverse MR was performed to investigate the causal effects of CeD on autoimmune traits. Following the application of Bonferroni correction for multiple testing, genetically determined seven autoimmune diseases are causally associated with CeD: Crohn’s disease (CD) (OR [95%CI] = 1.156 [1.106 ± 1.208], <i>P</i> = 1.27E–10), primary biliary cholangitis (PBC) (1.229 [1.143 ± 1.321], <i>P</i> = 2.53E–08), primary sclerosing cholangitis (PSC) (1.688 [1.466 ± 1.944], <i>P</i> = 3.56E–13), rheumatoid arthritis (RA) (1.231 [1.154 ± 1.313], <i>P</i> = 2.74E–10), systemic lupus erythematosus (SLE) (1.127 [1.081 ± 1.176], <i>P</i> = 2.59E–08), type 1 diabetes (T1D) (1.41 [1.238 ± 1.606], <i>P</i> = 2.24E–07), and asthma (1.414 [1.137 ± 1.758], <i>P</i> = 1.86E–03). The IVW analysis indicated that CeD increased the risk for seven diseases: CD (1.078 [1.044 ± 1.113], <i>P</i> = 3.71E–06), Graves’ disease (GD) (1.251 [1.127 ± 1.387], <i>P</i> = 2.34E–05), PSC (1.304 [1.227 ± 1.386], <i>P</i> = 8.56E–18), psoriasis (PsO) (1.12 [1.062 ± 1.182], <i>P</i> = 3.38E–05), SLE (1.301[1.22 ± 1.388], <i>P</i> = 1.25E–15), T1D (1.3[1.228 ± 1.376], <i>P</i> = 1.57E–19), and asthma (1.045 [1.024 ± 1.067], <i>P</i> = 1.82E–05). The sensitivity analyses deemed the results reliable without pleiotropy. There are positive genetic correlations between various autoimmune diseases and CeD, and the latter also affects the predisposition to multiple autoimmune disorders in the European population.
DOI: 10.6084/m9.figshare.22700275
title: Diagnosis and treatment of tuberculosis presenting as uveitis based on stochastic simulation in systems biology

description: Tuberculous uveitis can be a manifestation of extrapulmonary tuberculosis or an allergic reaction to tuberculosis infection. The clinical signs and symptoms of other uveitis causes are generic, making a false diagnosis simple. We present a brief introduction to theoretical modelling and simulation in systems biology and explore the consequences of TB uveitis if left untreated. Patients were admitted to our hospital with recurrent fever. They had a previous definitive diagnosis of binocular uveitis and a positive interferon gamma release assay (IGRA) test result. At the time, there was no antituberculosis medicine available, and immunosuppressive and glucocorticoid therapy did not work. After the admission, their pleural fluid tested positive for <i>Mycobacterium tuberculosis</i>. No other causes to explain the fever were found. A diagnosis of tuberculosis was made, and their body temperature normalized after antituberculosis treatment and closed chest drainage. Vigilance should be exercised to rule out tuberculous uveitis in cases of unexplained uveitis; this calls for IGRA screening, tuberculin skin testing, and cyst imaging. For patients with latent tuberculosis infections, it is recommended to administer antituberculosis treatment, after excluding other possible causes, and to avoid using glucocorticoids in isolation.