cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.24373/pdsp-127
title: Peripheral Neuropathy

description: This concept set is inteded to identify patients with a diagnosis of peripheral neuropathy.
description: Health Services and Clinical Characteristics that Precede Diagnosis of Primary Hyperoxaluria Type 1 (Alnylam)
DOI: 10.24373/pdsp-86
title: Mental Health Clusters

description: This concept set contains diagnosis codes related to mental health along with more specific classification clusters including: Neglect, Anxiety disorder, OCD, Emotional Abuse, Physical Abuse, Sexual Abuse, Somatoform Disorder, Stress Disorder, Conduct Disorder, Impulse Control Disorder, Avoidant/Restrictive Food Intake, Other Eating and Feeding Disorder, Encopresis, Enuresis, Gender Dysphoria, Paraphilia, Sexual Dysfunction, Parasuicidality, Suicidality, Bipolar Disorder, Major Depression, Minor Depression, Catatonia, Delirium, Encephalopathy, Academic Developmental Disorder, ADHD, Autism Spectrum Disorder, Communication/Motor Disorder, Intellectual Disability, Personality Disorder, Psychotic Disorder, Schizoaffective Disorder, Schizophrenia, Hypersomnia, Insomnia, Parasomnias, Anger/Aggression, Anxiety Symptoms, Attention Symptoms, Depressive Symptoms, Hallucinations, Alcohol, Opioid Related, Other Substances, THC, Tobacco, Tic Disorder. This concept set was developed as the CHeQ typology. It is described in the paper titled "Electronic health records identify timely trends in childhood mental health conditions" (https://doi.org/10.1186/s13034-023-00650-7). Technical note: This concept set does not include a concept_id column to be utilized in the PEDSnet data model. It only contains ICD10 codes, but would need to be joined to the concept table on the icd10_code column to get the corresponding concept_ids.
description: This concept set contains diagnosis codes related to mental health and specific classification clusters.
description: This concept set was utilized in this study to identify mental health conditions in pediatric PASC patients.
DOI: 10.24373/pdsp-150
title: Myalgia

description: This concept set is inteded to identify patients with a diagnosis of myalgia.
description: The Researching COVID to Enhance Recovery (RECOVER) Post-Acute Sequelae of SARS-CoV-2 (PASC) Electronic Health Record (EHR) Cohort Study
DOI: 10.6084/m9.figshare.30546617
title: Identification of Latent Subgroups for Time-Varying Panel Data Models

description: This article introduces a time-varying panel data model that incorporates latent group structures, designed to tackle both individual heterogeneity and smooth structural changes over time. We develop an innovative center-augmented K-power means (KPM) methodology that promotes convergence of subjects toward their respective cluster centers, enabling the identification of latent group structures without requiring prior knowledge of group composition. This approach delivers both superior precision and computational efficiency. We provide rigorous theoretical foundations, demonstrating estimation consistency, accurate subgroup identification, and consistent selection of the number of groups. The efficacy of the proposed KPM method in accurately identifying the latent group structures in panel data is demonstrated through comprehensive numerical analysis, including simulation studies and two real-world applications.
DOI: 10.6084/m9.figshare.30546617.v1
title: Identification of Latent Subgroups for Time-varying Panel Data Models

description: This paper introduces a time-varying panel data model that incorporates latent group structures, designed to tackle both individual heterogeneity and smooth structural changes over time. We develop an innovative centre-augmented K-power means (KPM) methodology that promotes convergence of subjects toward their respective cluster centers, enabling the identification of latent group structures without requiring prior knowledge of group composition. This approach delivers both superior precision and computational efficiency. We provide rigorous theoretical foundations, demonstrating estimation consistency, accurate subgroup identification, and consistent selection of the number of groups. The efficacy of the proposed KPM method in accurately identifying the latent group structures in panel data is demonstrated through comprehensive numerical analysis, including simulation studies and two real-world applications.
DOI: 10.6084/m9.figshare.30546617.v2
title: Identification of Latent Subgroups for Time-Varying Panel Data Models

description: This article introduces a time-varying panel data model that incorporates latent group structures, designed to tackle both individual heterogeneity and smooth structural changes over time. We develop an innovative center-augmented K-power means (KPM) methodology that promotes convergence of subjects toward their respective cluster centers, enabling the identification of latent group structures without requiring prior knowledge of group composition. This approach delivers both superior precision and computational efficiency. We provide rigorous theoretical foundations, demonstrating estimation consistency, accurate subgroup identification, and consistent selection of the number of groups. The efficacy of the proposed KPM method in accurately identifying the latent group structures in panel data is demonstrated through comprehensive numerical analysis, including simulation studies and two real-world applications.
DOI: 10.15468/dl.frrzjh
title: Occurrence Download

description: A dataset containing 9 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cetopsorhamdia phantasia",
 "DecimalLatitude is not null",
 "DecimalLongitude is not null"
 ]
}

 The dataset includes 9 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009941-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y6kjzx
title: Occurrence Download

description: A dataset containing 583 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Mimosa camporum",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 583 records from 96 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009942-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.29286738
title: Different mechanisms of electroacupuncture and pregabalin in neuropathic pain-induced ultrastructure damage in a rat model of brachial plexus neuralgia

description: Brachial plexus neuralgia (BPN) can result from injury, trauma, or cancer, and it significantly impacts the patient’s quality of life. This study investigated electroacupuncture (EA) vs. pregabalin on the structural changes in the peripheral nervous system (PNS) and central nervous system (CNS) in rats with BPN. Male Sprague-Dawley rats were randomized to the sham-operated (Con), BPN (using cobra venom), BPN+EA (EA), and BPN+pregabalin (PGB) groups (<i>n</i> = 8/group). EA or pregabalin was given from postoperative day (POD)14 to POD35. Structural alterations were determined by transmission electron microscopy in the primary sensory cortex, forelimb region (S1FL), anterior cingulate cortex (ACC), hippocampus, thalamus, cervical, thoracic, and lumbar spinal cords on POD40, and in the bilateral brachial plexus and dorsal root ganglions (DRG) at the cervical, thoracic and lumbar levels. Compared with the CON group, BPN rats exhibited significant changes in mechanical withdrawal threshold (MWT) (<i>p</i> &lt; 0.05). The MWT showed a significant increase compared with the BNP group after EA or pregabalin (<i>p</i> &lt; 0.05), but the long-term analgesic effects of EA appeared superior to pregabalin (<i>p</i> &lt; 0.05). Furthermore, EA alleviated myelin sheath damage at the spinal cord levels. Damage, including demyelination, was limited to the ipsilateral DRG at the corresponding segment and bilateral CNS. Neuropathic pain-induced damage is limited to the ipsilateral DRG at corresponding segment and bilateral CNS pain centers. EA and pregabalin each partially attenuate neuropathic pain and alleviate neuronal damage in BPN, but EA has a longer-term analgesic effect.
DOI: 10.6084/m9.figshare.29286738.v1
title: Different mechanisms of electroacupuncture and pregabalin in neuropathic pain-induced ultrastructure damage in a rat model of brachial plexus neuralgia

description: Brachial plexus neuralgia (BPN) can result from injury, trauma, or cancer, and it significantly impacts the patient’s quality of life. This study investigated electroacupuncture (EA) vs. pregabalin on the structural changes in the peripheral nervous system (PNS) and central nervous system (CNS) in rats with BPN. Male Sprague-Dawley rats were randomized to the sham-operated (Con), BPN (using cobra venom), BPN+EA (EA), and BPN+pregabalin (PGB) groups (<i>n</i> = 8/group). EA or pregabalin was given from postoperative day (POD)14 to POD35. Structural alterations were determined by transmission electron microscopy in the primary sensory cortex, forelimb region (S1FL), anterior cingulate cortex (ACC), hippocampus, thalamus, cervical, thoracic, and lumbar spinal cords on POD40, and in the bilateral brachial plexus and dorsal root ganglions (DRG) at the cervical, thoracic and lumbar levels. Compared with the CON group, BPN rats exhibited significant changes in mechanical withdrawal threshold (MWT) (<i>p</i> &lt; 0.05). The MWT showed a significant increase compared with the BNP group after EA or pregabalin (<i>p</i> &lt; 0.05), but the long-term analgesic effects of EA appeared superior to pregabalin (<i>p</i> &lt; 0.05). Furthermore, EA alleviated myelin sheath damage at the spinal cord levels. Damage, including demyelination, was limited to the ipsilateral DRG at the corresponding segment and bilateral CNS. Neuropathic pain-induced damage is limited to the ipsilateral DRG at corresponding segment and bilateral CNS pain centers. EA and pregabalin each partially attenuate neuropathic pain and alleviate neuronal damage in BPN, but EA has a longer-term analgesic effect.
DOI: 10.6084/m9.figshare.29314565.v1
title: Brain metastases’ radiologic phenotypes: correlation between tumor’s consistency, extent of edema, histologic features and vascular territory affected

description: Morbidity and mortality related to brain metastases (BM) are affected by their intracranial distribution, consistency (solid vs. cystic), and extent of peritumoral brain edema. We have hypothesized that the vascular properties of the different vascular territories of the brain may influence differences in BM’s radiologic morphologies. This is a retrospective study of all adult patients (age ≥18 years) with histopathological confirmed BM. Based on radiologic features, the patients were divided into 3 groups: solid, cystic-necrotic, and purely cystic. Data on different variables were extracted for eligible cases and used for statistical-based comparisons between groups. Following categorization according to radiologic phenotype, 61 (32.3%), 85 (45%), and 43 (22.7%) cases were considered solid, cystic-necrotic, and purely cystic, respectively. On univariate analysis, the purely cystic phenotype was significantly associated with male gender, posterior cerebral circulation, lung cancer (vs. breast cancer), neuroendocrine tumor, and older age. On multivariate analysis, posterior circulation (OR = 8.782, <i>p</i> &lt; 0.001), neuroendocrine tumor (OR = 4.539, <i>p</i> = 0.046) and older age (OR = 1.075, <i>p</i> = 0.021) remained significant. In addition, on multivariate analysis, severe edema was significantly associated with the solid phenotype, anterior circulation and age &lt; 55 years cases. The two cerebral circulations are significantly associated with different BM radiologic phenotypes as well as with differences in the extent of peri-lesional brain edema. Furthermore, several epidemiological, histological and molecular variables are also associated with these important radiologic features. As our data on factors associated with BM radiologic morphologies grows, so our understanding of the relevant pathophysiology will expand, leading to practical implications affecting morbidity and prognosis.
DOI: 10.6084/m9.figshare.29314565
title: Brain metastases’ radiologic phenotypes: correlation between tumor’s consistency, extent of edema, histologic features and vascular territory affected

description: Morbidity and mortality related to brain metastases (BM) are affected by their intracranial distribution, consistency (solid vs. cystic), and extent of peritumoral brain edema. We have hypothesized that the vascular properties of the different vascular territories of the brain may influence differences in BM’s radiologic morphologies. This is a retrospective study of all adult patients (age ≥18 years) with histopathological confirmed BM. Based on radiologic features, the patients were divided into 3 groups: solid, cystic-necrotic, and purely cystic. Data on different variables were extracted for eligible cases and used for statistical-based comparisons between groups. Following categorization according to radiologic phenotype, 61 (32.3%), 85 (45%), and 43 (22.7%) cases were considered solid, cystic-necrotic, and purely cystic, respectively. On univariate analysis, the purely cystic phenotype was significantly associated with male gender, posterior cerebral circulation, lung cancer (vs. breast cancer), neuroendocrine tumor, and older age. On multivariate analysis, posterior circulation (OR = 8.782, <i>p</i> &lt; 0.001), neuroendocrine tumor (OR = 4.539, <i>p</i> = 0.046) and older age (OR = 1.075, <i>p</i> = 0.021) remained significant. In addition, on multivariate analysis, severe edema was significantly associated with the solid phenotype, anterior circulation and age &lt; 55 years cases. The two cerebral circulations are significantly associated with different BM radiologic phenotypes as well as with differences in the extent of peri-lesional brain edema. Furthermore, several epidemiological, histological and molecular variables are also associated with these important radiologic features. As our data on factors associated with BM radiologic morphologies grows, so our understanding of the relevant pathophysiology will expand, leading to practical implications affecting morbidity and prognosis.
DOI: 10.6084/m9.figshare.31321039
title: Edge-Covariate Differential Privacy for Covariate-Assisted Networks

description: Differential privacy has become a crucial tool for protecting sensitive information. In network data, both the existence of edges and their associated covariates may reveal private details, making their unprotected release a serious privacy concern. However, most existing approaches to edge privacy fail to account for the protection of edge-specific covariates. In this paper, we address this gap by proposing a unified framework for safeguarding both edges and edge-wise covariates in covariate-assisted network models. We introduce edge-covariate differential privacy, a privacy notion designed to simultaneously protect the presence of edges and their associated covariates. To assess its impact on network modeling, we investigate the fundamental privacy–utility tradeoff of parameter estimation under a joint latent space model. Our approach employs a mixed privatization mechanism that combines randomized response for edges with a Laplace mechanism for covariates. We establish asymptotic consistency and minimax optimality, up to logarithmic factors, for parameter estimation under this privacy constraint. Extensive simulation studies and an application to a real-world citation network demonstrate that our method achieves a favorable balance between strong privacy guarantees and estimation accuracy.
DOI: 10.6084/m9.figshare.31321039.v1
title: Edge-Covariate Differential Privacy for Covariate-Assisted Networks

description: Differential privacy has become a crucial tool for protecting sensitive information. In network data, both the existence of edges and their associated covariates may reveal private details, making their unprotected release a serious privacy concern. However, most existing approaches to edge privacy fail to account for the protection of edge-specific covariates. In this paper, we address this gap by proposing a unified framework for safeguarding both edges and edge-wise covariates in covariate-assisted network models. We introduce edge-covariate differential privacy, a privacy notion designed to simultaneously protect the presence of edges and their associated covariates. To assess its impact on network modeling, we investigate the fundamental privacy–utility tradeoff of parameter estimation under a joint latent space model. Our approach employs a mixed privatization mechanism that combines randomized response for edges with a Laplace mechanism for covariates. We establish asymptotic consistency and minimax optimality, up to logarithmic factors, for parameter estimation under this privacy constraint. Extensive simulation studies and an application to a real-world citation network demonstrate that our method achieves a favorable balance between strong privacy guarantees and estimation accuracy.
DOI: 10.6084/m9.figshare.31321029.v1
title: Martingale Posterior Distributions for Log-concave Density Functions

description: The family of log-concave density functions is an important class and contains various well known probability distributions, including the normal. Due to the shape restriction, it is possible to find a nonparametric estimate of the density; the nonparametric maximum likelihood estimator (NPMLE). However, uncertainty quantification about the NPMLE via confidence bounds is less well developed. Bayesian methods are also largely absent, though it is possible to construct constrained density functions and to use Markov chain Monte Carlo (MCMC) to sample from the posterior. In this paper, we start with the NPMLE and use a version of the martingale posterior distribution to determine uncertainty. The algorithm can be implemented in parallel and hence is fast. We prove existence of the posterior using suitable convergence of a submartingale. We also present illustrations and comparisons with alternative approaches which include real data.
DOI: 10.34740/kaggle/ds/8935874
title: food-ingred-dataset
DOI: 10.6084/m9.figshare.31321047
title: Exosomes derived from AHR-overexpressing human umbilical cord mesenchymal stem cells attenuate H/R injury via AHR/NLRP3 pathway

description: Myocardial hypoxia-reoxygenation (H/R) injury is a frequently observed pathological event in various cardiovascular conditions. Despite the therapeutic promise of human umbilical cord mesenchymal stem cells (hUC-MSCs) in alleviating myocardial damage, their clinical use faces obstacles such as limited implantation efficiency, poor retention, and reduced post-transplantation viability. Exosomes secreted by hUC-MSCs have emerged as a viable alternative, potentially addressing these challenges. Nonetheless, the underlying mechanisms through which these exosomes confer cardioprotection have yet to be fully elucidated. This study aims to explore the protective effect of hUC-MSCs exosomes on myocardial H/R injury via the aryl hydrocarbon receptor (AHR)/NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway and to assess their impact on immune cell phenotype conversion. hUC-MSCs exosomes significantly upregulated AHR expression, inhibited NLRP3-related inflammatory protein expression, enhanced myocardial cell survival, and reduced apoptosis. The protective effect of hUC-MSCs exosomes was abolished following AHR knockdown. Additionally, exosomes from AHR-overexpressing hUC-MSCs promoted the conversion of macrophages, dendritic cells (DCs), and T cells to an anti-inflammatory phenotype, thereby further enhancing myocardial protection. These findings indicted that exosomes from AHR-overexpressing hUC-MSCs protect myocardium via AHR/NLRP3 signaling, improving immune microenvironment and offering new therapeutic potential.
DOI: 10.6084/m9.figshare.31321021
title: The efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: A meta-analysis and reconstructed individual patient data analysis

description: Some immune checkpoint inhibitors (ICI) has been used for men with specific metastatic castration-resistant prostate cancer (mCRPC). However, inconsistent results of ICI for unselected mCRPC population raise concerns. The primary outcomes were overall survival (OS) and radiographic progression-free survival (PFS), and the secondary outcomes included objective response rate (ORR). Individual patient data (IPD) were reconstructed from reported survival curve, and Kaplan–Meier method was used to evaluate the efficacy. Data of 1580 patients from 21 clinical trials were analyzed without biomarker-selected indications. The pooled 1-y and 2-y OS were 63% and 39%, while pooled 6-month and 12-month PFS were 41% and 17%. ICI plus other agent showed more OS and PFS benefits comparing with mono or dual ICI therapy (All P &lt; .05). Combination therapy with ICI showed encouraging but preliminary signs in mCRPC. Future large trials focusing on combination regimens of ICI are needed. <b>Registration:</b> PROSPERO (CRD420251087847).
DOI: 10.6084/m9.figshare.31321021.v1
title: The efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: A meta-analysis and reconstructed individual patient data analysis

description: Some immune checkpoint inhibitors (ICI) has been used for men with specific metastatic castration-resistant prostate cancer (mCRPC). However, inconsistent results of ICI for unselected mCRPC population raise concerns. The primary outcomes were overall survival (OS) and radiographic progression-free survival (PFS), and the secondary outcomes included objective response rate (ORR). Individual patient data (IPD) were reconstructed from reported survival curve, and Kaplan–Meier method was used to evaluate the efficacy. Data of 1580 patients from 21 clinical trials were analyzed without biomarker-selected indications. The pooled 1-y and 2-y OS were 63% and 39%, while pooled 6-month and 12-month PFS were 41% and 17%. ICI plus other agent showed more OS and PFS benefits comparing with mono or dual ICI therapy (All P &lt; .05). Combination therapy with ICI showed encouraging but preliminary signs in mCRPC. Future large trials focusing on combination regimens of ICI are needed. <b>Registration:</b> PROSPERO (CRD420251087847).