cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17632/kvv2jpjpz7
title: We need our bones: a pH-responsive drug delivery system for perspective microenvironment-driven therapy of osteoporosis

description: In this study, we report the development of a pH-responsive drug delivery system based on waste-derived zeolite X, functionalised with chitosan as a pH-sensitive linker and loaded with risedronate. Zeolite X was prepared in three ionic forms (Na⁺, Ca²⁺, and Ca²⁺/Mg²⁺) to investigate the influence of cation composition on drug loading, release behaviour, and biological response. Release studies demonstrated a pronounced pH-dependent behaviour, with rapid drug release under acidic conditions (pH 4.0) mimicking osteoclast-mediated bone resorption, and minimal release at physiological pH (7.4). Kinetic analysis indicated diffusion-dominated release in acidic environments, while desorption-controlled behaviour prevailed at neutral pH. The in vitro cytotoxicity assessment confirmed the biological safety of the Na⁺ and Ca²⁺/Mg²⁺ systems. Overall, this work demonstrates a sustainable and tuneable platform for microenvironment-driven, localised osteoporosis therapy.

Abbreviation of the samples: NaX/CaX/Ca/MgX - zeolite X in the the Na, Ca, Ca/Mg forms, CH- chitosan, RIS- risedronate.

BET/
Contains raw BET surface area and porosity analysis reports for all investigated materials (csv or xlsx). Files include adsorption–desorption isotherms and calculated textural parameters.

Cytotoxicity/
Raw biological evaluation data obtained using MC3T3-E1 preosteoblast cells (csv or xlsx).
Live/Dead staining – fluorescence microscopy images used to assess cell viability (tiff).
MTT assay – spreadsheet with absorbance values and calculated cell viability percentages (csv or xlsx).

FTIR_PAS/
Raw FTIR spectra recorded in PAS mode (OMNIC format) for all materials, including:
pristine zeolite-based systems,
chitosan-modified samples,
risedronate-loaded systems.

Release/
Contains the raw spreadsheet file with drug release data used for all kinetic analyses. The file includes time-resolved absorbance values measured under different pH conditions (csv or xlsx).

SEM_EDS/
Raw SEM–EDS mapping data for selected materials. Subfolders correspond to individual samples:
NaXCHRIS
CaXCHRIS
CaMgXCHRIS
Each folder contains:
reference SEM images,
elemental EDS maps (counts) for individual elements (e.g., Na, Ca, Mg, Si, Al, O, P).
All files are provided in original tiff format.

XRD/
Raw X-ray diffraction data for all analyzed samples. For each material, two file types are provided:
text-based diffraction intensity data (for plotting and analysis),
native instrument XRD data files (xrdml and csv).

XRF/
Raw XRF elemental composition results provided as a spreadsheet file. The data were used to determine bulk chemical composition and cation exchange efficiency (xlsx).

General notes
All data are presented without normalization, smoothing, or baseline correction, unless stated otherwise in the manuscript.
File names correspond directly to sample codes used in the publication.
The raw data provided here fully support the figures, tables, and analyses reported in the article.
DOI: 10.25625/5vepgm/qoimgq
title: 02.csv

description: :unav
DOI: 10.25625/5vepgm/ddcugi
title: Form.css

description: :unav
DOI: 10.17632/kvv2jpjpz7.1
title: We need our bones: a pH-responsive drug delivery system for perspective microenvironment-driven therapy of osteoporosis

description: In this study, we report the development of a pH-responsive drug delivery system based on waste-derived zeolite X, functionalised with chitosan as a pH-sensitive linker and loaded with risedronate. Zeolite X was prepared in three ionic forms (Na⁺, Ca²⁺, and Ca²⁺/Mg²⁺) to investigate the influence of cation composition on drug loading, release behaviour, and biological response. Release studies demonstrated a pronounced pH-dependent behaviour, with rapid drug release under acidic conditions (pH 4.0) mimicking osteoclast-mediated bone resorption, and minimal release at physiological pH (7.4). Kinetic analysis indicated diffusion-dominated release in acidic environments, while desorption-controlled behaviour prevailed at neutral pH. The in vitro cytotoxicity assessment confirmed the biological safety of the Na⁺ and Ca²⁺/Mg²⁺ systems. Overall, this work demonstrates a sustainable and tuneable platform for microenvironment-driven, localised osteoporosis therapy.

Abbreviation of the samples: NaX/CaX/Ca/MgX - zeolite X in the the Na, Ca, Ca/Mg forms, CH- chitosan, RIS- risedronate.

BET/
Contains raw BET surface area and porosity analysis reports for all investigated materials (csv or xlsx). Files include adsorption–desorption isotherms and calculated textural parameters.

Cytotoxicity/
Raw biological evaluation data obtained using MC3T3-E1 preosteoblast cells (csv or xlsx).
Live/Dead staining – fluorescence microscopy images used to assess cell viability (tiff).
MTT assay – spreadsheet with absorbance values and calculated cell viability percentages (csv or xlsx).

FTIR_PAS/
Raw FTIR spectra recorded in PAS mode (OMNIC format) for all materials, including:
pristine zeolite-based systems,
chitosan-modified samples,
risedronate-loaded systems.

Release/
Contains the raw spreadsheet file with drug release data used for all kinetic analyses. The file includes time-resolved absorbance values measured under different pH conditions (csv or xlsx).

SEM_EDS/
Raw SEM–EDS mapping data for selected materials. Subfolders correspond to individual samples:
NaXCHRIS
CaXCHRIS
CaMgXCHRIS
Each folder contains:
reference SEM images,
elemental EDS maps (counts) for individual elements (e.g., Na, Ca, Mg, Si, Al, O, P).
All files are provided in original tiff format.

XRD/
Raw X-ray diffraction data for all analyzed samples. For each material, two file types are provided:
text-based diffraction intensity data (for plotting and analysis),
native instrument XRD data files (xrdml and csv).

XRF/
Raw XRF elemental composition results provided as a spreadsheet file. The data were used to determine bulk chemical composition and cation exchange efficiency (xlsx).

General notes
All data are presented without normalization, smoothing, or baseline correction, unless stated otherwise in the manuscript.
File names correspond directly to sample codes used in the publication.
The raw data provided here fully support the figures, tables, and analyses reported in the article.
DOI: 10.25625/5vepgm/i84rg6
title: Separator.css

description: :unav
DOI: 10.25625/5vepgm/pcrgfd
title: rand_11.tab

description: :unav
DOI: 10.25625/5vepgm/rxrhu3
title: subex_8.tab

description: :unav
DOI: 10.25625/5vepgm/chki0n
title: 04.csv

description: :unav
DOI: 10.25625/5vepgm/ejscfu
title: 01.csv

description: :unav
DOI: 10.25625/5vepgm/mewewj
title: Message.css

description: :unav
DOI: 10.25625/5vepgm/mxgv29
title: VBox.js

description: :unav
DOI: 10.15468/dl.ggsp9r
title: Occurrence Download

description: A dataset containing 122447 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Perca fluviatilis",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2004"
 ]
}

 The dataset includes 122447 records from 139 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000018-260129131611470/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17632/mm8g9d7c2b
title: Replication package for the article "Effects of Market Competition and Labour Flexibility on Technical Efficiency: Evidence from Indian Manufacturing Plants"

description: The replication package contains data, codes and instructions (ReadMe.pdf) to replicate all the results (tables and figures) presented in the main text, appendix and supplementary file of the article "Effects of Market Competition and Labour Flexibility on Technical Efficiency: Evidence from Indian Manufacturing Plants".
DOI: 10.25625/5vepgm/lvvv2o
title: rand_5.tab

description: :unav
DOI: 10.25625/5vepgm/sjvc8w
title: 10.csv

description: :unav
DOI: 10.25625/5vepgm/feugji
title: 06.csv

description: :unav
DOI: 10.17632/mm8g9d7c2b.1
title: Replication package for the article "Effects of Market Competition and Labour Flexibility on Technical Efficiency: Evidence from Indian Manufacturing Plants"

description: The replication package contains data, codes and instructions (ReadMe.pdf) to replicate all the results (tables and figures) presented in the main text, appendix and supplementary file of the article "Effects of Market Competition and Labour Flexibility on Technical Efficiency: Evidence from Indian Manufacturing Plants".
DOI: 10.25625/5vepgm/oyvrip
title: PennController.js

description: :unav
DOI: 10.25625/5vepgm/t0ubmc
title: subex_4.tab

description: :unav
DOI: 10.25625/5vepgm/e4m4e3
title: DashedAcceptabilityJudgment.js

description: :unav
DOI: 10.25625/5vepgm/ulyisg
title: rand_9.tab

description: :unav
DOI: 10.25625/5vepgm/i6gpjb
title: FlashSentence.css

description: :unav
DOI: 10.25625/5vepgm/xcfcdk
title: 07.csv

description: :unav
DOI: 10.25625/5vepgm/pwxudk
title: subex_7.tab

description: :unav
DOI: 10.17632/xdtb6v3n8h.2
title: Biogeochemical Data from ODP Site 721A: Climatic Variability and Its Influence on the Indian Ocean Monsoon and on the NW Arabian Sea Oxygen Minimum Zone

description: This dataset supports the research article titledClimatic Variability and Its Influence on the Indian Ocean Monsoon and on the NW Arabian Sea Oxygen Minimum Zone, which investigates the influence of abrupt climatic shifts, specifically Dansgaard–Oeschger (DO) events 11 to 9, on the Indian Ocean Monsoon system and the oxygen minimum zone (OMZ) in the northwestern Arabian Sea.
The data were generated from 11 samples collected from Ocean Drilling Program (ODP) Site 721A and include:
Total Organic Carbon (TOC) concentrations
Carbon/Nitrogen (C/N) ratios
Stable isotope compositions (δ¹³C_bulk, δ¹⁵N_bulk) of bulk sediments
Relative abundances of planktonic foraminifera G. bulloides and G. ruber
Shell-based stable isotope data (δ¹³C and δ¹⁸O) for G. ruber (partially available)
Radiocarbon dates (AMS ¹⁴C) and calibrated age model information
These proxies were used to reconstruct changes in productivity, OMZ intensity, and monsoonal variability during rapid climate transitions. The data are intended for reuse by the paleoclimate and oceanography research communities and may support future regional or global comparisons of monsoon–OMZ dynamics.
DOI: 10.25625/5vepgm/ic2li1
title: rand_16.tab

description: :unav
DOI: 10.25625/5vepgm/hgtgb2
title: Question.js

description: :unav
DOI: 10.25625/5vepgm/hq7k1c
title: 09.csv

description: :unav
DOI: 10.25625/5vepgm/utz81u
title: DashedSentence.css

description: :unav
DOI: 10.17632/x262ykm7vg
title: Emergency Escape Ramp Scene Dataset

description: Our dataset comprises 500 RGB-D images, where the depth maps were generated using the AdelaiDepth (LeReS) framework. AdelaiDepth employs a relative depth learning strategy, focusing on encoding the ordinal relationships between pixels. It also applies scale and shift normalization to align the depth values, thereby mitigating depth-scale ambiguity. All images are resized to 512×512 pixels. The dataset contains nine classes: background, emergency escape ramp, escape ramp sign, road surface, emergency lane, guardrail, no parking sign, and person. Out of the total dataset, 450 images are allocated for training, while the remaining 50 are reserved for testing.
DOI: 10.25625/5vepgm/d8q6in
title: rand_3.tab

description: :unav
DOI: 10.25625/5vepgm/bf4cwg
title: Form.js

description: :unav
DOI: 10.25625/5vepgm/tmppdb
title: rand_2.tab

description: :unav
DOI: 10.17632/x262ykm7vg.1
title: Emergency Escape Ramp Scene Dataset

description: Our dataset comprises 500 RGB-D images, where the depth maps were generated using the AdelaiDepth (LeReS) framework. AdelaiDepth employs a relative depth learning strategy, focusing on encoding the ordinal relationships between pixels. It also applies scale and shift normalization to align the depth values, thereby mitigating depth-scale ambiguity. All images are resized to 512×512 pixels. The dataset contains nine classes: background, emergency escape ramp, escape ramp sign, road surface, emergency lane, guardrail, no parking sign, and person. Out of the total dataset, 450 images are allocated for training, while the remaining 50 are reserved for testing.
DOI: 10.25625/5vepgm/vvncoj
title: Scale.css

description: :unav
DOI: 10.25625/5vepgm/dpzcfl
title: subex_2.tab

description: :unav
DOI: 10.25625/5vepgm/erjdbx
title: 08.csv

description: :unav
DOI: 10.25625/5vepgm/w51nsg
title: rand_1.tab

description: :unav
DOI: 10.17632/vy22m8dmcb
title: Body Image and Emotional Distress in Non-binary and Genderqueer Adults and Matched Peers

description: Data consisting of NBGQ participants (n=12) and their matched peers (n=12), with data from the BAT-scale and the DASS-21.
DOI: 10.25625/5vepgm/fap2rc
title: rand_7.tab

description: :unav
DOI: 10.25625/5vepgm/wqyzlr
title: 15.csv

description: :unav
DOI: 10.17632/vy22m8dmcb.2
title: Body Image and Emotional Distress in Non-binary and Genderqueer Adults and Matched Peers

description: Data consisting of NBGQ participants (n=12) and their matched peers (n=12), with data from the BAT-scale and the DASS-21.
DOI: 10.25625/5vepgm/n1tplq
title: rand_6.tab

description: :unav
DOI: 10.25625/5vepgm/bbcw7y
title: 14.csv

description: :unav
DOI: 10.25625/5vepgm/it97hi
title: rand_13.tab

description: :unav
DOI: 10.25625/5vepgm/7rxbaf
title: subex_5.tab

description: :unav
DOI: 10.17632/t5czpbpcjz
title: AVALIAÇÃO CLÍNICA DO RISCO CARDIOVASCULAR E FATORES ASSOCIADOS À ADESÃO TERAPÊUTICA DE PESSOAS HIPERTENSAS EM FAMÍLIAS QUILOMBOLAS

description: Em síntese, os dados mostram que pessoas hipertensas em famílias quilombolas apresentam risco cardiovascular relevante, frequentemente associado a baixa adesão terapêutica e fatores socioeconômicos de vulnerabilidade.
O estudo reforça a importância de intervenções integradas e equitativas, reconhecendo o contexto social e cultural dessas comunidades como elemento essencial para melhorar o controle da hipertensão e prevenir complicações cardiovasculares.
DOI: 10.25625/5vepgm/mntbrl
title: Separator.js

description: :unav
DOI: 10.25625/5vepgm/yyoad5
title: consent.html

description: :unav
DOI: 10.17632/t5czpbpcjz.1
title: AVALIAÇÃO CLÍNICA DO RISCO CARDIOVASCULAR E FATORES ASSOCIADOS À ADESÃO TERAPÊUTICA DE PESSOAS HIPERTENSAS EM FAMÍLIAS QUILOMBOLAS

description: Em síntese, os dados mostram que pessoas hipertensas em famílias quilombolas apresentam risco cardiovascular relevante, frequentemente associado a baixa adesão terapêutica e fatores socioeconômicos de vulnerabilidade.
O estudo reforça a importância de intervenções integradas e equitativas, reconhecendo o contexto social e cultural dessas comunidades como elemento essencial para melhorar o controle da hipertensão e prevenir complicações cardiovasculares.
DOI: 10.25625/5vepgm/yt5ocs
title: rand_10.tab

description: :unav
DOI: 10.25625/5vepgm/3ibzgx
title: subex_3.tab

description: :unav
DOI: 10.25625/5vepgm/ijbrx1
title: 03.csv

description: :unav
DOI: 10.25625/5vepgm/xyg4ii
title: Message.js

description: :unav
DOI: 10.25625/5vepgm/vnemle
title: Question.css

description: :unav
DOI: 10.25625/5vepgm/hmiis6
title: 16.csv

description: :unav
DOI: 10.25625/5vepgm/hsfid1
title: rand_8.tab

description: :unav
DOI: 10.17632/2yc77xm6mv
title: General Information and Graphical Data Visualizations of the Leaf Endomicrobiome of Garden Sage (Salvia officinalis L.)

description: This dataset provides nucleic acid sequence information derived from the leaf endomicrobiome of Garden Sage (Salvia officinalis L.). Microbial diversity is visualised using Krona charts, while the core endomicrobiome is illustrated through Sankey plot analysis. 

Note: R1/S1, R2/S2, and R3/S3 represent biological replicates/samples of leaf tissue collected from healthy Salvia officinalis plants.
DOI: 10.25625/5vepgm/cjejz8
title: DashedSentence.js

description: :unav
DOI: 10.25625/5vepgm/d5mt7a
title: 13.csv

description: :unav
DOI: 10.17632/2yc77xm6mv.1
title: General Information and Graphical Data Visualizations of the Leaf Endomicrobiome of Garden Sage (Salvia officinalis L.)

description: This dataset provides nucleic acid sequence information derived from the leaf endomicrobiome of Garden Sage (Salvia officinalis L.). Microbial diversity is visualised using Krona charts, while the core endomicrobiome is illustrated through Sankey plot analysis. 

Note: R1/S1, R2/S2, and R3/S3 represent biological replicates/samples of leaf tissue collected from healthy Salvia officinalis plants.
DOI: 10.25625/5vepgm/mae6ul
title: paymentroutine.js

description: :unav
DOI: 10.25625/5vepgm/2j79yz
title: main.js

description: :unav
DOI: 10.25625/5vepgm/mwksgx
title: 01_Auswertung.pdf

description: :unav
DOI: 10.25625/5vepgm/uptiz2
title: subex_1.tab

description: :unav
DOI: 10.17632/mw2nkfv7yt
title: Dataset 'The Role of Technology Acceptance in the Implementation of Social Customer Relationship Management in Brazilian Micro and Small Enterprises'"

description: The data were used in an article that aimed to investigate the extent to which Perceived Usefulness (PU) and Perceived Ease of Use (PEOU) predict the intensity of Social Customer Relationship Management (SCRM) usage. A quantitative study was conducted using a survey questionnaire (N = 121). The data were analyzed through Structural Equation Modeling using Partial Least Squares (PLS-SEM). The dataset contains the scores of each participant for each item corresponding to its respective construct. Data related to sociodemographic characteristics were not disclosed in order to preserve participant anonymity, in accordance with the ethical procedures adopted in the study.

The study tested three hypotheses:
H1(+): Higher levels of PEOU in micro and small enterprises (MSEs) are associated with higher levels of PU.
H2(+): Higher levels of PEOU in MSEs are associated with greater use of SCRM processes.
H3(+): Higher levels of PU in MSEs are associated with greater use of SCRM processes.

The results indicate that PEOU positively influences SCRM usage and that greater use of SCRM is associated with superior performance in MSEs, highlighting its strategic value. However, limited managerial familiarity with these tools may constrain effective implementation.
DOI: 10.25625/5vepgm/9lxfib
title: rand_15.tab

description: :unav
DOI: 10.17632/mw2nkfv7yt.1
title: Dataset 'The Role of Technology Acceptance in the Implementation of Social Customer Relationship Management in Brazilian Micro and Small Enterprises'"

description: The data were used in an article that aimed to investigate the extent to which Perceived Usefulness (PU) and Perceived Ease of Use (PEOU) predict the intensity of Social Customer Relationship Management (SCRM) usage. A quantitative study was conducted using a survey questionnaire (N = 121). The data were analyzed through Structural Equation Modeling using Partial Least Squares (PLS-SEM). The dataset contains the scores of each participant for each item corresponding to its respective construct. Data related to sociodemographic characteristics were not disclosed in order to preserve participant anonymity, in accordance with the ethical procedures adopted in the study.

The study tested three hypotheses:
H1(+): Higher levels of PEOU in micro and small enterprises (MSEs) are associated with higher levels of PU.
H2(+): Higher levels of PEOU in MSEs are associated with greater use of SCRM processes.
H3(+): Higher levels of PU in MSEs are associated with greater use of SCRM processes.

The results indicate that PEOU positively influences SCRM usage and that greater use of SCRM is associated with superior performance in MSEs, highlighting its strategic value. However, limited managerial familiarity with these tools may constrain effective implementation.
DOI: 10.25625/5vepgm/4pi9f1
title: Scale.js

description: :unav
DOI: 10.25625/5vepgm/v0sojf
title: gesamt_data.tab

description: :unav
DOI: 10.25625/5vepgm/zxyeef
title: global_main.css

description: :unav
DOI: 10.25625/5vepgm/kldynb
title: rand_12.tab

description: :unav
DOI: 10.25625/5vepgm/cqjfyj
title: readme.txt

description: readme Datei mit Erläuterungen
DOI: 10.25625/5vepgm/xu8xlo
title: subex_9.tab

description: :unav
DOI: 10.25625/5vepgm/bmgm7a
title: 11.csv

description: :unav
DOI: 10.25625/5vepgm/5pthwh
title: global_z.css

description: :unav
DOI: 10.25625/5vepgm/iuwhvi
title: rand_4.tab

description: :unav
DOI: 10.5281/zenodo.15698335
title: Accompanying files for "A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites"

description: This upload contains files documented in a preprint.

Preprint: https://doi.org/10.1101/2025.07.25.666630

The files uploaded here are:

Structures:



Alphafold3 (1) predictions for PfVPS13L1 (split in 2 pieces: 1-3600; 3281-5988), PfVPS13L2 (split in 3 pieces: 1-2822; 2140-5096; 4401-7594), PfVPS13L5 (split in 2 pieces: 1-4805; 3668-6769), PfVPS13L16 (split in 2 pieces: 1-4916; 3868-5415) and PgVPS13L6 used for the domain cartoons presented in Fig. 3D and Extended Data Fig. 4. Five confidence-ranked structures are presented for each protein sequence. The annotated full length structure of PfVPS13L1 (presented in Fig. 4B-D) was aligned on PyMOL (2) and is also included in the PfVPS13L1 zip as a .pse file. The domain colored structures of PfVPS13L2, 5 and 6  and PgVPS13L6 (presented in Extended Data Fig. 4b) are included in the corresponding zip files as .pse files.

Alphafold3 (1) interaction prediction of PfVPS13L1 N-term (a.a. 1-2976) and PfVAP (presented in Extended Data Fig. 6F).

Alphafold3 (1) interaction prediciton of the C-terminal PH domain of PfVPS13L1 (a.a. 5864-5988) and the C-terminal HEPN-L domain of PfAegerolysin presented in Fig. 5 (a.a. 681-827) (presented in Fig. 5f and Extended Data Fig. 8h). Sequences and alignments used for conservation coloring in Fig. 5f are also included in the .zip file. 


Plasmids:



All partially annotated sequences for all transfected plasmids in the study, organized into 4 categories.


Code:



Python codes for identifying FFAT motifs in a given fasta file using the scoring matrix from Slee et al. (3) or the one proposed for Plasmodium in this article (the latter was removed from the second version of the article). The code was partially written by ChatGPT (OpenAI, 2025).


 

References

1. Abramson, J et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature (2024).

2. The PyMOL Molecular Graphics System, Version 2.0. Schrödinger LLC.

3. Slee, J.A. & Levine, T.P. Systematic prediction of FFAT motifs across eukaryote proteomes identifies nucleolar and eisosome proteins with the predicted capacity to form bridges to the endoplasmic reticulum. Contact (Thousand Oaks) (2019).