cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9938333.v1
title: Fluorogenic biosensor immobilisation within surface modified fluoropolymer microdevices for rapid smartphone antibiotic susceptibility testing

description: This dataset is for data analysis associated with the article 'Exploiting Open Source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology'. It contains the raw images and Excel analysis of microtitre plates (MTP) and microcapillary film (MCF) for milk matrix experiments, POLIR quantification, and first experiment testing fluorescence on POLIR.
DOI: 10.6084/m9.figshare.9938333.v3
title: Data associated with the paper 'Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology'

description: This dataset is for data analysis associated with the article 'Exploiting Open Source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology'. It contains the raw images and Excel analysis of microtitre plates (MTP) and microcapillary film (MCF) for milk matrix experiments, POLIR quantification, and first experiment testing fluorescence on POLIR.
DOI: 10.6084/m9.figshare.9938333.v2
title: Fluorogenic biosensor immobilisation within surface modified fluoropolymer microdevices for rapid smartphone antibiotic susceptibility testing

description: This dataset is for data analysis associated with the article 'Exploiting Open Source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology'. It contains the raw images and Excel analysis of microtitre plates (MTP) and microcapillary film (MCF) for milk matrix experiments, POLIR quantification, and first experiment testing fluorescence on POLIR.
DOI: 10.6084/m9.figshare.9938279
title: Molecular docking and molecular dynamics simulation studies to identify potent AURKA inhibitors: assessing the performance of density functional theory, MM-GBSA and mass action kinetics calculations

description: Molecular docking and molecular dynamics simulation studies to identify potent AURKA inhibitors: assessing the performance of density functional theory, MM-GBSA and mass action kinetics calculations
DOI: 10.6084/m9.figshare.9938279.v2
title: Molecular docking and molecular dynamics simulation studies to identify potent AURKA inhibitors: assessing the performance of density functional theory, MM-GBSA and mass action kinetics calculations

description: Molecular docking and molecular dynamics simulation studies to identify potent AURKA inhibitors: assessing the performance of density functional theory, MM-GBSA and mass action kinetics calculations
DOI: 10.6084/m9.figshare.9938264
title: Brain targeting of resveratrol through intranasal lipid vesicles labelled with gold nanoparticles: <i>in vivo</i> evaluation and bioaccumulation investigation using computed tomography and histopathological examination

description: Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were developed and labelled with gold nanoparticles (GNPs). The water maze test was utilised to identify the effect on spatial memory recovery. The treated rats were examined for cellular uptake and bioaccumulation of drug in the brain using computed tomography (CT) and histopathological examination utilising GNPs as a biomarker. Compared with nanoemulsions, transferosomes displayed higher permeation of up to 81.29 ± 2.64% and higher fluorescence intensity with <i>p</i>
DOI: 10.6084/m9.figshare.9938264.v1
title: Brain targeting of resveratrol through intranasal lipid vesicles labelled with gold nanoparticles: <i>in vivo</i> evaluation and bioaccumulation investigation using computed tomography and histopathological examination

description: Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were developed and labelled with gold nanoparticles (GNPs). The water maze test was utilised to identify the effect on spatial memory recovery. The treated rats were examined for cellular uptake and bioaccumulation of drug in the brain using computed tomography (CT) and histopathological examination utilising GNPs as a biomarker. Compared with nanoemulsions, transferosomes displayed higher permeation of up to 81.29 ± 2.64% and higher fluorescence intensity with <i>p</i>
DOI: 10.25392/leicester.data.9938228
title: Eye Movements and the Perceptual Span in Mongolian Reading

description: This folder contains a data file and analysis script for an experiment examining reading times by native Mongolian readers. In this experiment, text in vertical and horizontal orientations was presented either entirely as normal or in a gaze-contingent moving window paradigm in which text was presented normally within a only a narrow region around fixation. Five windows were used: small symmetrical windows extending 0.5 degrees each side of fixation, small and large asymmetric windows extending further in the direction of reading (0.5 degrees counter to the direction of reading and either 1.5 or 2.5 degrees in the direction of reading), and small and large asymmetrical windows extending further counter to the direction of reading (extended 0.5 degrees in the direction or reading and either 1.5 or 2.5 degrees counter to the direction of reading).
DOI: 10.6084/m9.figshare.9938252
title: Metadata record for: A dataset on human perception of and response to wildfire smoke

description: This dataset contains key characteristics about the data described in the Data Descriptor A dataset on human perception of and response to wildfire smoke. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format<br><br>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.25392/leicester.data.9938228.v1
title: Eye Movements and the Perceptual Span in Mongolian Reading

description: This folder contains a data file and analysis script for an experiment examining reading times by native Mongolian readers. In this experiment, text in vertical and horizontal orientations was presented either entirely as normal or in a gaze-contingent moving window paradigm in which text was presented normally within a only a narrow region around fixation. Five windows were used: small symmetrical windows extending 0.5 degrees each side of fixation, small and large asymmetric windows extending further in the direction of reading (0.5 degrees counter to the direction of reading and either 1.5 or 2.5 degrees in the direction of reading), and small and large asymmetrical windows extending further counter to the direction of reading (extended 0.5 degrees in the direction or reading and either 1.5 or 2.5 degrees counter to the direction of reading).
DOI: 10.6084/m9.figshare.9938252.v2
title: Metadata record for: A dataset on human perception of and response to wildfire smoke

description: This dataset contains key characteristics about the data described in the Data Descriptor A dataset on human perception of and response to wildfire smoke. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format<br><br>Versioning Note:Version 2 was generated when the metadata format was updated from JSON to JSON-LD. This was an automatic process that changed only the format, not the contents, of the metadata.<br>
DOI: 10.6084/m9.figshare.9938252.v1
title: Metadata record for: A dataset on human perception of and response to wildfire smoke

description: This dataset contains key characteristics about the data described in the Data Descriptor A dataset on human perception of and response to wildfire smoke. <br> Contents: <br> 1. human readable metadata summary table in CSV format 2. machine readable metadata file in JSON format
DOI: 10.6084/m9.figshare.9938171
title: PubChem All Unique Molecular Formulae October 2019

description: PubChem All Unique Molecular Formulae October 2019 generated by downloading all compounds in PubChem (96million compounds), stripping salts with CDK and then calculating their molecular formula. List was then grouped by molecular formulae to give only Unique formulae. All work performed in Knime. File contains about 3million unique molecular formulae.<br>File is a simple text file with each unique formula on a new row.
DOI: 10.6084/m9.figshare.9938144
title: Supplementary Material for: How to Increase Adherence and Compliance in Acne Treatment? A Combined Strategy of SMS and Visual Instruction Leaflet

description: <b><i>Introduction:</i></b> Acne is a common skin disease with important psychosocial impact. Often inadequate compliance affects the efficacy of the therapy. Because of emerging use of mobile and electronic health technology, the recent literature evaluated the helpfulness of the tools in medication adherence. The first goal of our study was to evaluate the adherence to therapy with topical adapalene 0.3%/benzoyl peroxide (A-BPO) 2.5% in different groups of patients who received explicative information supported by different strategies. The second goal was to evaluate the patient’s quality of life and skin parameters. <b><i>Materials and Methods:</i></b> We enrolled 126 subjects with mild to severe acne vulgaris. They were randomized into 3 groups of 42 patients each and applied daily topical A-BPO (0.3%, 2.5%) for 12 weeks. The first group (G1) was trained on the gel application by an explicative leaflet. The second group (G2) received the same instructions as group 1 and a daily SMS to remind them of the application of the product. The third group (G3) only received standard instructions. Evaluations were performed at the beginning of treatment (T0) and after 12 weeks (T1): assessment of acne severity using the Investigator’s Global Assessment (IGA) Scale for Acne Severity, quality of life by the Cardiff Acne Disability Index (CADI) and the Patient-Doctor Relationship Depth-of-Relationship Scale (PDRDS), skin pH, grade of hydration and adherence to treatment with a 7-day recall calendar were also measured. <b><i>Results:</i></b> After 12 weeks of therapy, we observed a reduction in IGA in all groups confirming the clinical efficacy of the product. In the multiple comparison analysis of IGA score reduction, a significant difference was found in G2 versus G1 and G2 versus G3, while the G1 versus G3 comparison was not statistically significant. However, the leaflet group (G1) showed better results compared to the no-leaflet group (G3). Supporting these data, we observed that adherence days correlated positively with the improvement of the single parameters. Moreover, we observed that SMS and leaflet groups had a greater improvement in quality of life evaluated by CADI and PDRDS scores. <b><i>Conclusions:</i></b> According to our data, this experimental setup based on text message service and leaflet service is inexpensive and easy to use. Physicians could consider using these items in their practice to enhance patient adherence and satisfaction as well as treatment outcome.
DOI: 10.6084/m9.figshare.9938171.v1
title: PubChem All Unique Molecular Formulae October 2019

description: PubChem All Unique Molecular Formulae October 2019 generated by downloading all compounds in PubChem (96million compounds), stripping salts with CDK and then calculating their molecular formula. List was then grouped by molecular formulae to give only Unique formulae. All work performed in Knime. File contains about 3million unique molecular formulae.<br>File is a simple text file with each unique formula on a new row.
DOI: 10.6084/m9.figshare.9938144.v1
title: Supplementary Material for: How to Increase Adherence and Compliance in Acne Treatment? A Combined Strategy of SMS and Visual Instruction Leaflet

description: <b><i>Introduction:</i></b> Acne is a common skin disease with important psychosocial impact. Often inadequate compliance affects the efficacy of the therapy. Because of emerging use of mobile and electronic health technology, the recent literature evaluated the helpfulness of the tools in medication adherence. The first goal of our study was to evaluate the adherence to therapy with topical adapalene 0.3%/benzoyl peroxide (A-BPO) 2.5% in different groups of patients who received explicative information supported by different strategies. The second goal was to evaluate the patient’s quality of life and skin parameters. <b><i>Materials and Methods:</i></b> We enrolled 126 subjects with mild to severe acne vulgaris. They were randomized into 3 groups of 42 patients each and applied daily topical A-BPO (0.3%, 2.5%) for 12 weeks. The first group (G1) was trained on the gel application by an explicative leaflet. The second group (G2) received the same instructions as group 1 and a daily SMS to remind them of the application of the product. The third group (G3) only received standard instructions. Evaluations were performed at the beginning of treatment (T0) and after 12 weeks (T1): assessment of acne severity using the Investigator’s Global Assessment (IGA) Scale for Acne Severity, quality of life by the Cardiff Acne Disability Index (CADI) and the Patient-Doctor Relationship Depth-of-Relationship Scale (PDRDS), skin pH, grade of hydration and adherence to treatment with a 7-day recall calendar were also measured. <b><i>Results:</i></b> After 12 weeks of therapy, we observed a reduction in IGA in all groups confirming the clinical efficacy of the product. In the multiple comparison analysis of IGA score reduction, a significant difference was found in G2 versus G1 and G2 versus G3, while the G1 versus G3 comparison was not statistically significant. However, the leaflet group (G1) showed better results compared to the no-leaflet group (G3). Supporting these data, we observed that adherence days correlated positively with the improvement of the single parameters. Moreover, we observed that SMS and leaflet groups had a greater improvement in quality of life evaluated by CADI and PDRDS scores. <b><i>Conclusions:</i></b> According to our data, this experimental setup based on text message service and leaflet service is inexpensive and easy to use. Physicians could consider using these items in their practice to enhance patient adherence and satisfaction as well as treatment outcome.
DOI: 10.6084/m9.figshare.9938114
title: Supplementary Material for: Southeast Asian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives

description: Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate the implementation process of PGx into routine clinical practice. Part of these efforts include the formation of PGx working groups working on PGx research, synthesis, and dissemination of PGx data and creation of PGx implementation strategies. In Asia, the Southeast Asian Pharmacogenomics Research Network (SEAPharm) is established to enable and strengthen PGx research among the various PGx communities within but not limited to countries in SEA; with the ultimate goal to support PGx implementation in the region. From the perspective of SEAPharm member countries, there are several key elements essential for PGx implementation at the national level. They include pharmacovigilance database, PGx research, health economics research, dedicated laboratory to support PGx testing for both research and clinical use, structured PGx education, and supportive national health policy. The status of these essential elements is presented here to provide a broad picture of the readiness for PGx implementation among the SEAPharm member countries, and to strengthen the PGx research network and practice in this region.
DOI: 10.6084/m9.figshare.9938138
title: Supplementary Material for: Clinical and Spectrophotometric Evaluation of Skin Photoadaptation in Vitiligo Patients after a Short Cycle of NB-UVB Phototherapy

description: <b><i>Background:</i></b> The phenomenon of photoadaptation to narrow-band ultraviolet B (NB-UVB) radiation has been previously described in vitiligo and has usually been clinically measured by the assessment of the minimal erythema dose (MED) after phototesting. <b><i>Objectives:</i></b> To assess the photoadaptive response in vitiligo and healthy skin after NB-UVB phototherapy not only clinically, but also by spectrophotometry. <b><i>Materials and Methods:</i></b> Fourteen patients affected by generalized vitiligo underwent NB-UVB phototherapy twice weekly for 12 weeks. Before and after phototherapy, a phototesting procedure was administered on vitiligo patches and adjacent healthy skin with a solar simulated radiation (SSR). Visual assessment of the MED took place after 24 h. A spectrophotometer was used to assess the a* value and the melanin index (MI*), as signs of skin erythema and pigmentation. The photoadaptation factor (MED-PF) and the a* photoadaptation factor (a*-PF) were calculated. <b><i>Results:</i></b> After NB-UVB phototherapy, both vitiligo and healthy skin showed an increase in MED and MI* values and a reduction of skin erythema compared to baseline (<i>p</i> &lt; 0.05). MED-PF data showed a photoadaptation in 10 (71.4%) vitiligo lesions and in 12 (85.7%) healthy skin areas. The assessment of the a*-PF showed a negative mean percentage value in all affected and unaffected skin areas. <b><i>Conclusions:</i></b> A short cycle of NB-UVB phototherapy can induce photoadaptation in vitiligo by increasing the MED and reducing skin erythema after stimulation with SSR. This is most likely due to the physical filter function induced by ultraviolet radiation.
DOI: 10.6084/m9.figshare.9938141
title: TOR inhibition interrupts the metabolic homeostasis by shifting the carbon–nitrogen balance in <i>Chlamydomonas reinhardtii</i>

description: The allocation of nutrient resources to growth and metabolism is an essential function for controlling biomass accumulation in photoautotrophic organisms. One essential protein complex involved in this process is the target of rapamycin (TOR) kinase. It has been shown that the inhibition of TOR leads to a considerable upsurge in the amino acid levels. This molecular phenotype relies mainly on the availability of light, carbon (C) and nitrogen (N). To validate the time-resolved response of C and N metabolites, we used a targeted gas chromatography mass spectrometery (GC-MS)-based metabolomic approach, where we examined the response of <i>Chlamydomonas reinhardtii</i> upon TOR inhibition under C-limited condition, namely extended darkness. Contrary to C-supplemented conditions, the rapid increase in the amino acid levels is suppressed almost completely 4 h after TOR inhibition, confirming that C supply is essential to raise the amino acid levels mediated by their <i>de novo</i> synthesis. An exception to this observation was the levels of aspartate, which is presumably synthesized via the anaplerotic pathway. In agreement with previous reports, TOR repression, under these C-limited conditions, leads to a significant reduction in the C/N ratio, corroborating with the crucial role of the pathway in maintaining the metabolic balance of the cells and consequently propelling growth.
DOI: 10.6084/m9.figshare.9938141.v1
title: TOR inhibition interrupts the metabolic homeostasis by shifting the carbon–nitrogen balance in <i>Chlamydomonas reinhardtii</i>

description: The allocation of nutrient resources to growth and metabolism is an essential function for controlling biomass accumulation in photoautotrophic organisms. One essential protein complex involved in this process is the target of rapamycin (TOR) kinase. It has been shown that the inhibition of TOR leads to a considerable upsurge in the amino acid levels. This molecular phenotype relies mainly on the availability of light, carbon (C) and nitrogen (N). To validate the time-resolved response of C and N metabolites, we used a targeted gas chromatography mass spectrometery (GC-MS)-based metabolomic approach, where we examined the response of <i>Chlamydomonas reinhardtii</i> upon TOR inhibition under C-limited condition, namely extended darkness. Contrary to C-supplemented conditions, the rapid increase in the amino acid levels is suppressed almost completely 4 h after TOR inhibition, confirming that C supply is essential to raise the amino acid levels mediated by their <i>de novo</i> synthesis. An exception to this observation was the levels of aspartate, which is presumably synthesized via the anaplerotic pathway. In agreement with previous reports, TOR repression, under these C-limited conditions, leads to a significant reduction in the C/N ratio, corroborating with the crucial role of the pathway in maintaining the metabolic balance of the cells and consequently propelling growth.
DOI: 10.25392/leicester.data.9937988
title: Customer survey questions

description: These are the questions from the survey Beyond the Gaze completed with customers resulting in 1323 responses. Findings can be found in the briefing and in the book 2020 Paying for Sex in a Digital Age: UK and US Perspectives (Sanders, Brents and Wakefield).
DOI: 10.25392/leicester.data.9937988.v1
title: Customer survey questions

description: These are the questions from the survey Beyond the Gaze completed with customers resulting in 1323 responses. Findings can be found in the briefing and in the book 2020 Paying for Sex in a Digital Age: UK and US Perspectives (Sanders, Brents and Wakefield).
DOI: 10.6084/m9.figshare.9937967
title: Supplementary Material for: Prevalence of Skin Disease in Urban Haiti: A Cross-Sectional Study

description: The prevalence of skin disease varies with geographic location and may be affected by cultural factors. In Haiti, the combination of poor health care access, infrastructure lack, and natural disasters may affect the prevalence of skin conditions. Unfortunately, little epidemiological information has been obtained on the prevalence of skin diseases in Haiti. The objective of this study is to describe data on the prevalence of dermatological conditions in urban areas of Haiti. Univariate, bivariate, and χ<sup>2</sup> analyses were used to evaluate associations. During February 2016, we documented 137 patients. The mean age was 27.7 years; most of the subjects were women (61.3%) in a cohort mostly adult (67.1%). The infectious and inflammatory dermatoses were the most prevalent (74.2%). Infectious skin diseases were more prevalent in men and in adults in general (<i>p</i> &lt; 0.01). Inflammatory conditions were also more common in adults (<i>p</i> &lt; 0.05). Additionally, alopecia and dyschromia were limited to women (<i>p</i> &lt; 0.01). Infectious skin diseases, in particular fungal infections, were amongst the most common diagnoses in the urban area of Haiti. Therefore, improved access to antimicrobial and anti-inflammatory medications would likely benefit Haitian patients with dermatological conditions. These findings may help local public health officials and future dermatological expeditions better serve this population.
DOI: 10.6084/m9.figshare.9937928
title: Salibu Effect

description: This is the raw data of a paper "Evaluation of cropping method for perennial ratoon rice (SALIBU)"