cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30607064
title: Supplementary Material for: Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex Following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model

description: Introduction: The combination of Prenatal Alcohol Exposure (PAE) and Placental Insufficiency (PI) places infants at an increased risk for preterm birth and may worsen brain injury and neurobehavioral outcomes. In this preclinical study, the effect of PAE+PI on lateral, medial, and ventral prefrontal cortex (PFC), striatum and corpus callosum microstructure were investigated using diffusion tensor imaging (DTI). These brain regions are important for executive and higher cognitive functions, like cognitive flexibility.
Methods: Pregnant Long-Evans rat dams voluntarily drank 5% ethanol in saccharin water or plain saccharin water until embryonic day 18 (E18) to mimic moderate PAE. On E19, an open laparotomy was completed, and the uterine arteries were transiently occluded for one hour. The dams in the sham group underwent the same procedure, but without uterine arteries occlusion. Offspring delivered normally on E22 and matured with their dams. At postnatal day 35 (P35), tissue was collected from male and female rat offspring from all four prenatal treatment groups (Sham, PAE, PI, and PAE+PI). Fixed brain tissue was then scanned ex vivo on a Bruker 11.7 T MRI. Fractional anisotropy (FA) and directional diffusion were measured in regions of interest (ROI). Two-way ANOVA with Tukey’s correction was used, with p&lt;0.05 significant.
Results: Diffusion Tensor Imaging (DTI) analyses of the PFC (n=14-30/group) revealed a significant impact of the prenatal exposure/insult on the FA (p&lt;0.05), with sham having the lowest FA (0.24 ± 0.01) and PI having the highest FA (0.28 ± 0.02). The lateral PFC was significantly impacted by prenatal exposure/insult with sham having the highest radial diffusivity (RD; 4.97x10-4 ± 2.20x10-5 mm2/s; p&lt;0.05) and mean diffusivity (MD; 4.41x10-4 ± 2.10x10-5 mm2/s; p&lt;0.05) compared to the other groups. The striatum was sensitive to the prenatal exposure/insult, with the axial diffusivity (AD), RD, and MD all significantly increased in the PAE group and decreased in the PI group (p&lt;0.05). In the corpus callosum, the prenatal exposure/insult significantly decreased the AD (p&lt;0.05; PAE+PI AD: 5.00x10-4 ± 4.60x10-5 mm2/s). 
Conclusion: While all areas analyzed were impacted by the prenatal insults, the striatum, which consists primarily of efferent pathways, appears more vulnerable to injury compared to the PFC. Additional studies are needed to characterize the impact this may have on function related to these critical brain regions.
DOI: 10.6084/m9.figshare.30607064.v1
title: Supplementary Material for: Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex Following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model

description: Introduction: The combination of Prenatal Alcohol Exposure (PAE) and Placental Insufficiency (PI) places infants at an increased risk for preterm birth and may worsen brain injury and neurobehavioral outcomes. In this preclinical study, the effect of PAE+PI on lateral, medial, and ventral prefrontal cortex (PFC), striatum and corpus callosum microstructure were investigated using diffusion tensor imaging (DTI). These brain regions are important for executive and higher cognitive functions, like cognitive flexibility.
Methods: Pregnant Long-Evans rat dams voluntarily drank 5% ethanol in saccharin water or plain saccharin water until embryonic day 18 (E18) to mimic moderate PAE. On E19, an open laparotomy was completed, and the uterine arteries were transiently occluded for one hour. The dams in the sham group underwent the same procedure, but without uterine arteries occlusion. Offspring delivered normally on E22 and matured with their dams. At postnatal day 35 (P35), tissue was collected from male and female rat offspring from all four prenatal treatment groups (Sham, PAE, PI, and PAE+PI). Fixed brain tissue was then scanned ex vivo on a Bruker 11.7 T MRI. Fractional anisotropy (FA) and directional diffusion were measured in regions of interest (ROI). Two-way ANOVA with Tukey’s correction was used, with p&lt;0.05 significant.
Results: Diffusion Tensor Imaging (DTI) analyses of the PFC (n=14-30/group) revealed a significant impact of the prenatal exposure/insult on the FA (p&lt;0.05), with sham having the lowest FA (0.24 ± 0.01) and PI having the highest FA (0.28 ± 0.02). The lateral PFC was significantly impacted by prenatal exposure/insult with sham having the highest radial diffusivity (RD; 4.97x10-4 ± 2.20x10-5 mm2/s; p&lt;0.05) and mean diffusivity (MD; 4.41x10-4 ± 2.10x10-5 mm2/s; p&lt;0.05) compared to the other groups. The striatum was sensitive to the prenatal exposure/insult, with the axial diffusivity (AD), RD, and MD all significantly increased in the PAE group and decreased in the PI group (p&lt;0.05). In the corpus callosum, the prenatal exposure/insult significantly decreased the AD (p&lt;0.05; PAE+PI AD: 5.00x10-4 ± 4.60x10-5 mm2/s). 
Conclusion: While all areas analyzed were impacted by the prenatal insults, the striatum, which consists primarily of efferent pathways, appears more vulnerable to injury compared to the PFC. Additional studies are needed to characterize the impact this may have on function related to these critical brain regions.
DOI: 10.6084/m9.figshare.30607060
title: Additional file 3 of Metformin protects against cyclophosphamide-induced ovarian fibrosis by MIF/CD74-mediated macrophage polarization

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.30607060.v1
title: Additional file 3 of Metformin protects against cyclophosphamide-induced ovarian fibrosis by MIF/CD74-mediated macrophage polarization

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.30607070
title: Supplementary Material for: Multiple risk factors controlled and mortality risks in chronic kidney disease

description: Abstract 
Introduction: Chronic kidney disease (CKD) is associated with elevated mortality risk. The study aimed to investigate the extent to which multiple risk factors controlled could attenuate CKD-related excess mortality. 
Methods: The study included 2,394 CKD patients and 15,962 non-CKD individuals from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Seven modifiable risk factors included blood pressure, body mass index, hemoglobin A1c, non-high-density lipoprotein cholesterol, smoking, physical activity, and diet. CKD patients were categorized by the number of controlled risk factors. Cox models were used to estimate associations between risk factors controlled and risks of all-cause and cause-specific mortality. 
Results: Among CKD patients, each additional risk factor control was significantly associated with a 19% lower risk of all-cause mortality (HR [hazard ratio]: 0.81; 95%CI [confidence interval]: 0.71-0.93), with the optimal control of 6-7 risk factors associated with a 59% lower risk of all-cause mortality (HR: 0.41; 95%CI: 0.19-0.90). Furthermore, compared with non-CKD individuals (death rate per 1000 person-years: 2.69 [95%CI: 1.77-4.09]), CKD patients with 6-7 risk factors controlled had no significantly different risks of all-cause mortality (absolute rate difference per 1000 person-years: 0.79 [95%CI: -2.65, 6.63]; HR: 1.29 [95%CI: 0.62-2.66]), cardiovascular disease mortality (absolute rate difference: 0.27 [95%CI: -0.80, 3.00]; HR: 1.51 [95%CI: 0.43-5.34]), and cancer mortality (absolute rate difference: 0.27 [95%CI: -0.80, 3.00]; HR: 1.06 [95%CI: 0.28-3.96]). 
Conclusions: Multiple risk factors controlled were associated with reduced CKD-related excess mortality. Optimal control of 6-7 factors was associated with the elimination of increased mortality risks relative to non-CKD individuals. These findings highlight the need for integrated management strategies targeting biological and lifestyle risk factors in CKD populations.
DOI: 10.6084/m9.figshare.30607070.v1
title: Supplementary Material for: Multiple risk factors controlled and mortality risks in chronic kidney disease

description: Abstract 
Introduction: Chronic kidney disease (CKD) is associated with elevated mortality risk. The study aimed to investigate the extent to which multiple risk factors controlled could attenuate CKD-related excess mortality. 
Methods: The study included 2,394 CKD patients and 15,962 non-CKD individuals from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Seven modifiable risk factors included blood pressure, body mass index, hemoglobin A1c, non-high-density lipoprotein cholesterol, smoking, physical activity, and diet. CKD patients were categorized by the number of controlled risk factors. Cox models were used to estimate associations between risk factors controlled and risks of all-cause and cause-specific mortality. 
Results: Among CKD patients, each additional risk factor control was significantly associated with a 19% lower risk of all-cause mortality (HR [hazard ratio]: 0.81; 95%CI [confidence interval]: 0.71-0.93), with the optimal control of 6-7 risk factors associated with a 59% lower risk of all-cause mortality (HR: 0.41; 95%CI: 0.19-0.90). Furthermore, compared with non-CKD individuals (death rate per 1000 person-years: 2.69 [95%CI: 1.77-4.09]), CKD patients with 6-7 risk factors controlled had no significantly different risks of all-cause mortality (absolute rate difference per 1000 person-years: 0.79 [95%CI: -2.65, 6.63]; HR: 1.29 [95%CI: 0.62-2.66]), cardiovascular disease mortality (absolute rate difference: 0.27 [95%CI: -0.80, 3.00]; HR: 1.51 [95%CI: 0.43-5.34]), and cancer mortality (absolute rate difference: 0.27 [95%CI: -0.80, 3.00]; HR: 1.06 [95%CI: 0.28-3.96]). 
Conclusions: Multiple risk factors controlled were associated with reduced CKD-related excess mortality. Optimal control of 6-7 factors was associated with the elimination of increased mortality risks relative to non-CKD individuals. These findings highlight the need for integrated management strategies targeting biological and lifestyle risk factors in CKD populations.
DOI: 10.6084/m9.figshare.30607073
title: Supplementary Material for: Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy

description: Abstract
Introduction
Early-onset obesity increases the risk of developing comorbidities and decreases life expectancy with many variables such as age of onset, severity, and duration of obesity each having an individual influence. Here, we present findings from a model that aims to assess the impact of early-onset obesity.
Methods 
The Early-Onset Obesity Model (EOObesity Model) was built by integrating data from clinical studies with demographic information. It categorizes information into four primary groups: prevalence, morbidity risk, mortality risk, and impact of obesity duration. Type 2 diabetes, cardiovascular events (fatal and non-fatal events, cardiovascular disease, and coronary heart disease), metabolic dysfunction-associated steatotic liver disease, asthma, obstructive sleep apnea, and cancer were evaluated over a range of age and body mass index (BMI) z-scores.
Results 
The EOObesity Model provides a systematic approach for estimating the impact of early-onset obesity on risk of comorbidities and on life expectancy by considering individual patient weight trajectories. We test different scenarios to illustrate the potential impact of age of onset and severity of obesity on the risk of various comorbidities, on life expectancy, and on disability-adjusted life years. The model indicates that severe early-onset obesity has a high impact on life expectancy with, for example, up to 42 years of life lost if a patient has a BMI z-score of 4 by the age of 4 years.
Discussion
The model and these scenarios underscore the predicted substantially detrimental effects of early-onset and prolonged obesity on life expectancy, and the increased risks of obesity-related comorbidities. They suggest that morbidity and mortality risks increase with obesity duration and severity in a nonlinear manner, thereby supporting the view that early weight loss intervention and obesity prevention strategies may reduce long-term health risks substantially.
DOI: 10.6084/m9.figshare.30607073.v1
title: Supplementary Material for: Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy

description: Abstract
Introduction
Early-onset obesity increases the risk of developing comorbidities and decreases life expectancy with many variables such as age of onset, severity, and duration of obesity each having an individual influence. Here, we present findings from a model that aims to assess the impact of early-onset obesity.
Methods 
The Early-Onset Obesity Model (EOObesity Model) was built by integrating data from clinical studies with demographic information. It categorizes information into four primary groups: prevalence, morbidity risk, mortality risk, and impact of obesity duration. Type 2 diabetes, cardiovascular events (fatal and non-fatal events, cardiovascular disease, and coronary heart disease), metabolic dysfunction-associated steatotic liver disease, asthma, obstructive sleep apnea, and cancer were evaluated over a range of age and body mass index (BMI) z-scores.
Results 
The EOObesity Model provides a systematic approach for estimating the impact of early-onset obesity on risk of comorbidities and on life expectancy by considering individual patient weight trajectories. We test different scenarios to illustrate the potential impact of age of onset and severity of obesity on the risk of various comorbidities, on life expectancy, and on disability-adjusted life years. The model indicates that severe early-onset obesity has a high impact on life expectancy with, for example, up to 42 years of life lost if a patient has a BMI z-score of 4 by the age of 4 years.
Discussion
The model and these scenarios underscore the predicted substantially detrimental effects of early-onset and prolonged obesity on life expectancy, and the increased risks of obesity-related comorbidities. They suggest that morbidity and mortality risks increase with obesity duration and severity in a nonlinear manner, thereby supporting the view that early weight loss intervention and obesity prevention strategies may reduce long-term health risks substantially.
DOI: 10.6084/m9.figshare.30507108
title: Additional file 1 of Electrical vestibular stimulation to improve balance in older adults: a pilot randomized controlled trial

description: Supplementary Material 1: Table. Mean ± (SD) Phybrata power values for each group across sessions and conditions. This table reports mean ± standard deviation (SD) values of normalized Phybrata power for the Stimulation and Sham groups across four balance conditions: Floor Eyes Open (EO), Floor Eyes Closed (EC), Foam EO, and Foam EC. Data are shown for Sessions 1 through 18, as well as at 3-month (3 M) and 6-month (6 M) follow-ups. Session 1 values were normalized to 1.00; values for subsequent sessions reflect changes in performance relative to baseline. Lower values (i.e., negative deviations) indicate improved balance performance. Sample size (N) reflects the total number of participants per condition. The number of valid data points after outlier removal is indicated by n. All comparisons were conducted after removing extreme values defined by standard criteria. Significance was determined at the α = 0.05 level
DOI: 10.6084/m9.figshare.30507108.v1
title: Additional file 1 of Electrical vestibular stimulation to improve balance in older adults: a pilot randomized controlled trial

description: Supplementary Material 1: Table. Mean ± (SD) Phybrata power values for each group across sessions and conditions. This table reports mean ± standard deviation (SD) values of normalized Phybrata power for the Stimulation and Sham groups across four balance conditions: Floor Eyes Open (EO), Floor Eyes Closed (EC), Foam EO, and Foam EC. Data are shown for Sessions 1 through 18, as well as at 3-month (3 M) and 6-month (6 M) follow-ups. Session 1 values were normalized to 1.00; values for subsequent sessions reflect changes in performance relative to baseline. Lower values (i.e., negative deviations) indicate improved balance performance. Sample size (N) reflects the total number of participants per condition. The number of valid data points after outlier removal is indicated by n. All comparisons were conducted after removing extreme values defined by standard criteria. Significance was determined at the α = 0.05 level
DOI: 10.6084/m9.figshare.30607104
title: Additional file 1 of Basket trials in rare diseases: a systematic review of current practices, methodological challenges, and future directions

description: Supplementary Material 1.
DOI: 10.6084/m9.figshare.30607104.v1
title: Additional file 1 of Basket trials in rare diseases: a systematic review of current practices, methodological challenges, and future directions

description: Supplementary Material 1.
DOI: 10.15468/dl.hvefh7
title: Occurrence Download

description: A dataset containing 21 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Bursera lunanii",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present"
 ]
}

 The dataset includes 21 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030121-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.66np3k
title: Occurrence Download

description: A dataset containing 4902 species occurrences available in GBIF matching the query:
{
 "and" : [
 "OccurrenceStatus is Present",
 "TaxonKey is Taxodium mucronatum"
 ]
}

 The dataset includes 4902 records from 215 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030122-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.48723/vany-1s63
title: Codes and data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"
title: Kod och data för "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"

description: This dataset consists of code for reproducing the figures and statistical analyses from "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis" and its input data. The code (scripts.zip) is openly available. The files in the "data" folder contain personal data and can only be accessed after completing an assessment process. There are 12 R script files in scripts.zip, and the input data for these scripts are contained within the "data" folder. The input data are stored in text, Newick, or RDS format. The "data" contains 65 files of approximately 247MB total. The file size and path of each file in "data" can be found in the Data_file_list.txt file. For details on each file and instructions on running the code, please refer to README.pdf.
description: Denna datauppsättning består av kod för att reproducera siffrorna och statistiska analyserna från "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis" och dess indata. Koden (scripts.zip) är öppet tillgänglig. Filerna i mappen "data" innehåller personuppgifter och kan endast nås efter att en bedömningsprocess har slutförts. Det finns 12 R-skriptfiler i scripts.zip, och indata för dessa skript finns i mappen "data". Indata lagras i text-, Newick- eller RDS-format. "Data" innehåller 65 filer på totalt cirka 247 MB. Filstorleken och sökvägen för varje fil i "data" finns i filen Data_file_list.txt. För information om varje fil och instruktioner om hur du kör koden, se README.pdf.
DOI: 10.48723/cken-ea76
title: Codes and data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"
title: Kod och data för "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"

description: This dataset consists of code for reproducing the figures and statistical analyses from "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis" and its input data. The code (scripts.zip) is openly available. The files in the "data" folder contain personal data and can only be accessed after completing an assessment process. There are 12 R script files in scripts.zip, and the input data for these scripts are contained within the "data" folder. The input data are stored in text, Newick, or RDS format. The "data" contains 65 files of approximately 247MB total. The file size and path of each file in "data" can be found in the Data_file_list.txt file. For details on each file and instructions on running the code, please refer to README.pdf.
description: Denna datauppsättning består av kod för att reproducera siffrorna och statistiska analyserna från "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis" och dess indata. Koden (scripts.zip) är öppet tillgänglig. Filerna i mappen "data" innehåller personuppgifter och kan endast nås efter att en bedömningsprocess har slutförts. Det finns 12 R-skriptfiler i scripts.zip, och indata för dessa skript finns i mappen "data". Indata lagras i text-, Newick- eller RDS-format. "Data" innehåller 65 filer på totalt cirka 247 MB. Filstorleken och sökvägen för varje fil i "data" finns i filen Data_file_list.txt. För information om varje fil och instruktioner om hur du kör koden, se README.pdf.
DOI: 10.15468/dl.wtgrha
title: Occurrence Download

description: A dataset containing 120 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is CHN",
 "OccurrenceStatus is Present",
 "TaxonKey is Didymodon ditrichoides"
 ]
}

 The dataset includes 120 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030123-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zyqxjz
title: Occurrence Download

description: A dataset containing 3583444 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Dasiphora davurica, Eucalyptus fibrosa, Ipomoea triloba, Juglans cinerea, Juglans regia, Juglans sigillata, Knoxia roxburghii, Scleromitrion diffusum, Argentina anserina, Prunus mahaleb, Prunus salicina, Quercus rex, Stevia rebaudiana, Bertholletia excelsa, Pseudocydonia sinensis, Eremocitrus glauca, Crataegus pinnatifida, Eucalyptus virginea, Euphorbia pulcherrima, Ficus benjamina, Gossypium trilobum, Gynandropsis gynandra, Gynostemma pentaphyllum, Hibiscus yunnanensis, Lycium barbarum, Malus coronaria, Pyrus ussuriensis, Veratrum dahuricum, Kalanchoe daigremontiana, Scutellaria galericulata, Typha latifolia, Alnus glutinosa, Citrus limon, Citrus aurantium, Cynodon dactylon, Ebenus cretica, Eucalyptus camaldulensis, Reynoutria multiflora, Frangula alnus, Gossypium gossypioides, Hibiscus cannabinus, Hippophae salicifolia, Prunus cerasifera, Salsola tragus, Sparganium angustifolium, Stephania cephalantha, Digitaria exilis, Gossypium longicalyx, Hydrangea macrophylla, Magnolia amoena)",
 "BasisOfRecord is one of (Specimen, Human Observation, Observation, Machine Observation)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 3583444 records from 5523 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030102-251025141854904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.18112/openneuro.ds005925.v1.0.0
title: Synthetic dataset for inclusion in BIDS-examples