cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24303368
title: Additional file 1 of Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep

description: Additional file 1: Figure S1. Wool characteristics of ancestral-like coarse (ALC) and modern fine (MF) wool sheep at P120 and P180. (a) The phenotypic properties of ALC wool sheep at P120 and P180. (b) The phenotypic properties of MF wool sheep at P120 and P180. (c) Proportion of medullated and unmedullated wool fibers at different developmental stages in ALC sheep. (d) Proportion of medullated and unmedullated wool fibers at different developmental stages in MF sheep. Figure S2. Wool characteristics of ancestral-like coarse (ALC) and modern fine (MF) wool sheep at P120 and P180. (a) Phylogenetic tree showing the evolutionary relationships of Gtl2-sITSs in various species. (b) Percentage of heterozygotes and homozygotes between ALC wool and MF wool varieties. (c) A small fraction of sITS in different species. Figure S3. Pathway enrichment analysis performed using the significantly downregulated metabolites in ancestral-like coarse (ALC) lambskin tissue. Figure S4. IRF2BP2 genotypes of ALC and MF wool lambs in reciprocal cross families. The primers were listed in Table S5. Figure S5. Embryonic weight of Meg3-IG-DMR-KO mice and their siblings (negative control), **P &lt; 0.001. Figure S6. miRNAs in the Gtl2-miRNAs Locus inhibited multiple components of the PI3K-AKT Pathway. (a) The frequency of signaling pathways enriched by predicted target genes of up-regulated miRNAs in ALC group. (b) Schematic of the PI3K-mTOR pathway. (c) The up-regulated differentially expressed (DE) miRNAs at Gtl2-miRNAs locus and their predicted target genes in the PI3K-AKT pathway. Figure S7. Similar molecular mechanisms affect ALC wool traits and quality of lamb fur. a Curve graph of wool diameter distribution of Tan sheep. b Proportion of medullated and non-medullated wool of Tan sheep. c Integrated analysis of upregulated miRNAs and the functional annotation of their target genes between early developmental Tan and ALC lambs [38]. d Birth weight of ALC and MF wool lambs. e The skin ROS level of Coarse and Fine wool lambs were measured by H2-DCFDA, Coarse wool lambs: Ujimqin lambs (n = 30), Tan lambs (n = 10) and ALC wool lambs (n = 5). Fine wool lambs: Merino lambs (n = 60) and MF wool lambs (n = 5). f 8-OHdG immunostaining was perform in section of the Merino lamb skin. g The skin ROS level of adult Coarse/Fine wool sheep were measured by H2-DCFDA, Coarse wool sheep: Ujimqin sheep (n = 30), Tan sheep (n = 10) and ALC wool sheep (n = 5). Fine wool sheep: Merino sheep (n = 60) and MF wool sheep (n = 5). Figure S8. Interaction analysis of down-regulated DEPs in ALC group using online tool ( https://www.string-db.org/ ). Figure S9. Selective signal analysis of transcriptome data using different reference genomes. a The samples are obtained from half-siblings, genome version: GCA_000298735.2, Oar_V4.0. The blue dashed line: Fst = 0.6. b The samples are obtained from the reciprocal cross progeny, and the genome version is GCA_016772045.2. The blue dashed line: Fst = 0.8.
DOI: 10.6084/m9.figshare.24303368.v1
title: Additional file 1 of Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep

description: Additional file 1: Figure S1. Wool characteristics of ancestral-like coarse (ALC) and modern fine (MF) wool sheep at P120 and P180. (a) The phenotypic properties of ALC wool sheep at P120 and P180. (b) The phenotypic properties of MF wool sheep at P120 and P180. (c) Proportion of medullated and unmedullated wool fibers at different developmental stages in ALC sheep. (d) Proportion of medullated and unmedullated wool fibers at different developmental stages in MF sheep. Figure S2. Wool characteristics of ancestral-like coarse (ALC) and modern fine (MF) wool sheep at P120 and P180. (a) Phylogenetic tree showing the evolutionary relationships of Gtl2-sITSs in various species. (b) Percentage of heterozygotes and homozygotes between ALC wool and MF wool varieties. (c) A small fraction of sITS in different species. Figure S3. Pathway enrichment analysis performed using the significantly downregulated metabolites in ancestral-like coarse (ALC) lambskin tissue. Figure S4. IRF2BP2 genotypes of ALC and MF wool lambs in reciprocal cross families. The primers were listed in Table S5. Figure S5. Embryonic weight of Meg3-IG-DMR-KO mice and their siblings (negative control), **P &lt; 0.001. Figure S6. miRNAs in the Gtl2-miRNAs Locus inhibited multiple components of the PI3K-AKT Pathway. (a) The frequency of signaling pathways enriched by predicted target genes of up-regulated miRNAs in ALC group. (b) Schematic of the PI3K-mTOR pathway. (c) The up-regulated differentially expressed (DE) miRNAs at Gtl2-miRNAs locus and their predicted target genes in the PI3K-AKT pathway. Figure S7. Similar molecular mechanisms affect ALC wool traits and quality of lamb fur. a Curve graph of wool diameter distribution of Tan sheep. b Proportion of medullated and non-medullated wool of Tan sheep. c Integrated analysis of upregulated miRNAs and the functional annotation of their target genes between early developmental Tan and ALC lambs [38]. d Birth weight of ALC and MF wool lambs. e The skin ROS level of Coarse and Fine wool lambs were measured by H2-DCFDA, Coarse wool lambs: Ujimqin lambs (n = 30), Tan lambs (n = 10) and ALC wool lambs (n = 5). Fine wool lambs: Merino lambs (n = 60) and MF wool lambs (n = 5). f 8-OHdG immunostaining was perform in section of the Merino lamb skin. g The skin ROS level of adult Coarse/Fine wool sheep were measured by H2-DCFDA, Coarse wool sheep: Ujimqin sheep (n = 30), Tan sheep (n = 10) and ALC wool sheep (n = 5). Fine wool sheep: Merino sheep (n = 60) and MF wool sheep (n = 5). Figure S8. Interaction analysis of down-regulated DEPs in ALC group using online tool ( https://www.string-db.org/ ). Figure S9. Selective signal analysis of transcriptome data using different reference genomes. a The samples are obtained from half-siblings, genome version: GCA_000298735.2, Oar_V4.0. The blue dashed line: Fst = 0.6. b The samples are obtained from the reciprocal cross progeny, and the genome version is GCA_016772045.2. The blue dashed line: Fst = 0.8.
DOI: 10.6084/m9.figshare.24303371
title: Additional file 2 of Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep

description: Additional file 2: Table S1. The pedigree relationship between ALC and MF sheep in this study. Table S2. miRNAs in the Dlk-Gtl2 locus and their predicted target genes in the candidate pathway. Table S3. The predicted target genes of sITS-miRNA in the candidate pathway. Table S4. The separate enrichment analysis of the downregulated proteins in metabolic pathways of the ALC group. Table S5. Primers used in this study. Table S6. Guide RNA sequence information in Meg3 (IG-DMR)-KO mice.
DOI: 10.6084/m9.figshare.24303371.v1
title: Additional file 2 of Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep

description: Additional file 2: Table S1. The pedigree relationship between ALC and MF sheep in this study. Table S2. miRNAs in the Dlk-Gtl2 locus and their predicted target genes in the candidate pathway. Table S3. The predicted target genes of sITS-miRNA in the candidate pathway. Table S4. The separate enrichment analysis of the downregulated proteins in metabolic pathways of the ALC group. Table S5. Primers used in this study. Table S6. Guide RNA sequence information in Meg3 (IG-DMR)-KO mice.
DOI: 10.6084/m9.figshare.8045642.v1
title: Additional file 1: of Genome constitution and evolution of Elytrigia lolioides inferred from Acc1, EF-G, ITS, TrnL-F sequences and GISH

description: Table S1. The related species in Triticeae used in this study. (XLSX 21 kb)
DOI: 10.48677/7f56026d-56f5-4196-bae5-6e086256101c
title: Verwaltungsgrenzen (VGD) INSPIRE Stichtag 01.10.2023

description: Die Verwaltungsgrenzen Stichtag beinhalten die Grenzen der Verwaltungseinheiten Österreichs entsprechend der INSPIRE Richtlinie harmonisiert. 

Die Daten sind für folgende Grenzen vorhanden: 
1) Katastralgemeindegrenze
2) Gemeindegrenze
3) Bezirksgrenze
4) Bundesländergrenze
5) Staatsgrenze

Stichtag = Erstellungsdatum:
Die Daten sind zu diesem Tag der aktuellste Datenbestand des BEV.
Dies ist nicht ident mit dem Aufnahme- bzw. Vermessungsdatum.
DOI: 10.6084/m9.figshare.8045588
title: Additional file 1: of Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia

description: Table S1. Primers used for RT-qPCR. Table S2. The p value of two-way ANOVA analysis. Figure S1. Measurement of RVSP in different groups. Figure S2. The results of two-way ANOVA analysis. Figure S3. Hemodynamic studies, immunohistochemical evaluation, and gene expression of PAH-5w and Sil-5w groups. (ZIP 6575 kb)
DOI: 10.6084/m9.figshare.8045666
title: Additional file 4: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The association between EHD1 and vascular endothelial cell proliferation. (XLSX 25 kb)
DOI: 10.6084/m9.figshare.8045588.v1
title: Additional file 1: of Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia

description: Table S1. Primers used for RT-qPCR. Table S2. The p value of two-way ANOVA analysis. Figure S1. Measurement of RVSP in different groups. Figure S2. The results of two-way ANOVA analysis. Figure S3. Hemodynamic studies, immunohistochemical evaluation, and gene expression of PAH-5w and Sil-5w groups. (ZIP 6575 kb)
DOI: 10.6084/m9.figshare.8045669
title: Additional file 5: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The association between EHD1 and vascular endothelial cell migration. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.16439166
title: Supplementary Tables 2 and 3. The subantarctic lithospheric mantle

description: Major element compositions of olivine, clinopyroxene and spinbel and trace element contents of clinopyroxene
DOI: 10.6084/m9.figshare.16439166.v1
title: Supplementary Tables 2 and 3. The subantarctic lithospheric mantle

description: Major element compositions of olivine, clinopyroxene and spinbel and trace element contents of clinopyroxene
DOI: 10.6084/m9.figshare.19579958.v1
title: Additional file 1 of Identification and characterization of circular RNAs in association with the feed efficiency in Hu lambs

description: Additional file 1.
DOI: 10.6084/m9.figshare.14866335
title: Dolutegravir-based regimens in treatment-naive and treatment-experienced aging populations: analyses of 6 phase III clinical trials

description: <b>Background:</b> Older adults living with HIV (OALWH) are a growing population facing unique challenges to successful antiretroviral therapy. <b>Objective:</b> To assess efficacy and safety profiles of antiretroviral regimens, including those containing dolutegravir, in OALWH. <b>Methods:</b> Combined data from 6 phase III/IIIb trials in treatment-naive (ARIA, FLAMINGO, SINGLE, SPRING-2; <i>N</i> = 2634) and treatment-experienced (DAWNING, SAILING; <i>N</i> = 1339) participants receiving dolutegravir- or non–dolutegravir-based regimens were analyzed by age (&lt;50, ≥50 to &lt;65, and ≥65 years). Baseline data included comorbidities and numbers of concomitant medications. Week 48 efficacy outcomes included virologic response (HIV-1 RNA &lt;50 copies/mL) and CD4+ cell count change from baseline. Safety outcomes included incidence of adverse events (AEs), serious AEs, and AE-related withdrawals. <b>Results:</b> Use of ≥5 concomitant medications was more frequently reported among treatment-naive and treatment-experienced participants aged ≥50 to &lt;65 (30% [90/296] and 25% [57/227], respectively) and ≥65 years (43% [10/23] and 29% [4/14]) than among those aged &lt;50 years (13% [310/2315] and 11% [118/1098]). Comorbidities were more prevalent in the older age groups. For dolutegravir-based regimens, Week 48 rates of virologic response and change in CD4+ cell count were similar across age groups (treatment naive, 80–87% and 234–251 cells/mm<sup>3</sup>; treatment experienced, 70–100% and 105–156 cells/mm<sup>3</sup>, respectively). There were no major differences in safety outcomes in each age group. <b>Conclusions:</b> In these analyses of combined phase III/IIIb trial data, efficacy and safety of dolutegravir-based regimens were generally similar across age groups in treatment-naive or treatment-experienced participants. Polypharmacy and comorbidities were more common among OALWH than those aged &lt;50 years.
DOI: 10.6084/m9.figshare.20103942
title: Additional file 6 of Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis

description: Additional file 6.
DOI: 10.6084/m9.figshare.8045699
title: Additional file 9: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The overlap between Î˛2AR-dependent gene expression and EHD1-regulated gene expression. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.8045666.v1
title: Additional file 4: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The association between EHD1 and vascular endothelial cell proliferation. (XLSX 25 kb)
DOI: 10.6084/m9.figshare.8045642
title: Additional file 1: of Genome constitution and evolution of Elytrigia lolioides inferred from Acc1, EF-G, ITS, TrnL-F sequences and GISH

description: Table S1. The related species in Triticeae used in this study. (XLSX 21 kb)
DOI: 10.6084/m9.figshare.8045660
title: Additional file 3: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The association between EHD1 and tumor angiogenesis. (XLSX 59 kb)
DOI: 10.6084/m9.figshare.8045660.v1
title: Additional file 3: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The association between EHD1 and tumor angiogenesis. (XLSX 59 kb)
DOI: 10.6084/m9.figshare.8045669.v1
title: Additional file 5: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The association between EHD1 and vascular endothelial cell migration. (XLSX 26 kb)
DOI: 10.6084/m9.figshare.8045699.v1
title: Additional file 9: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

description: The overlap between Î˛2AR-dependent gene expression and EHD1-regulated gene expression. (XLSX 14 kb)
DOI: 10.6084/m9.figshare.19579958
title: Additional file 1 of Identification and characterization of circular RNAs in association with the feed efficiency in Hu lambs

description: Additional file 1.
DOI: 10.6084/m9.figshare.8050976
title: Additional file 1: of Identification of cucumber circular RNAs responsive to salt stress

description: Table S1. Physical position of unanchored scaffolds in merged ChrUn. (XLSX 17 kb)
DOI: 10.6084/m9.figshare.8050976.v1
title: Additional file 1: of Identification of cucumber circular RNAs responsive to salt stress

description: Table S1. Physical position of unanchored scaffolds in merged ChrUn. (XLSX 17 kb)
DOI: 10.6084/m9.figshare.8050985.v1
title: Additional file 3: of Identification of cucumber circular RNAs responsive to salt stress

description: Table S3. Primers used for circRNAs sequences validation. (XLSX 13 kb)
DOI: 10.6084/m9.figshare.20098763
title: Additional file 1 of A comparison of three bone graft struts for interbody fusion using a posterior approach for lower lumbar spinal tuberculosis in adults: a midterm follow-up study

description: Additional file 1. The datasets used and analyzed in this study.
DOI: 10.6084/m9.figshare.20098652.v1
title: Additional file 3 of De novo assembly provides new insights into the evolution of Elaeagnus angustifolia L.

description: Additional file 3: Table S16. 80 rapidly evolving genes in E. angustifolia.
DOI: 10.6084/m9.figshare.8051195
title: Fuzzy optimization model for electric vehicle routing problem with time windows and recharging stations

description: This is the experimental data of the manuscript entitled "fuzzy optimization model for electric vehicle routing problem with time windows and recharging stations". All data are saved in the file with txt format.
DOI: 10.7303/syn53502566.1
title: CI deficiency PD stratification
DOI: 10.6084/m9.figshare.16964656
title: China-LDRL: China’s surface water bodies, Large Dams, Reservoirs, and Lakes dataset

description: A dataset of China’s surface water bodies, Large Dams, Reservoirs, and Lakes (China-LDRL) by analyzing all available Landsat imagery in 2019 (19,338 images) in Google Earth Engine and very-high spatial resolution imagery in Google Earth.
DOI: 10.6084/m9.figshare.16964708
title: Monocyte-related gene biomarkers for latent and active tuberculosis

description: Monocytes are closely associated with tuberculosis (TB). Latent tuberculosis in some patients gradually develops into its active state. This study aimed to investigate the role of hub monocyte-associated genes in distinguishing latent TB infection (LTBI) from active TB. The gene expression profiles of 15 peripheral blood mononuclear cells (PBMCs) samples were downloaded from the gene expression omnibus (GEO) database, GSE54992. The monocyte abundance was high in active TB as evaluated by the Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm. The limma test and correlation analysis documented 165 differentially expressed monocyte-related genes (DEMonRGs) between latent TB and active TB. Functional annotation and enrichment analyses of the DEMonRGs using the database for annotation, visualization, and integration discovery (DAVID) tools showed enrichment of inflammatory response mechanisms and immune-related pathways. A protein-protein interaction network was constructed with a node degree ≥10. The expression levels of these hub DEMonRGs (<i>SERPINA1, FUCA2</i>, and <i>HP</i>) were evaluated and verified using several independent datasets and clinical settings. Finally, a single sample scoring method was used to establish a gene signature for the three DEMonRGs, distinguishing active TB from latent TB. The findings of the present study provide a better understanding of monocyte-related molecular fundamentals in TB progression and contribute to the identification of new potential biomarkers for the diagnosis of active TB.
DOI: 10.6084/m9.figshare.16958638.v1
title: Test of Weak Separability for Spatially Stationary Functional Field

description: For spatially dependent functional data, a generalized Karhunen-Loève expansion is commonly used to decompose data into an additive form of temporal components and spatially correlated coefficients. This structure provides a convenient model to investigate the space-time interactions, but may not hold for complex spatio-temporal processes. In this work, we introduce the concept of weak separability, and propose a formal test to examine its validity for non-replicated spatially stationary functional field. The asymptotic distribution of the test statistic that adapts to potentially diverging ranks is derived by constructing lag covariance estimation, which is easy to compute for practical implementation. We demonstrate the efficacy of the proposed test via simulations and illustrate its usefulness in two real examples: China PM 2.5 data and Harvard Forest data. Supplementary materials for this article are available online.
DOI: 10.5281/zenodo.10653041
title: Dataset related to article "Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features"

description: This record contains raw data related to article “Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features"

Abstract



Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis.
DOI: 10.5281/zenodo.10653042
title: Dataset related to article "Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features"

description: This record contains raw data related to article “Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features"

Abstract



Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis.