cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.8858894.v1
title: A health risk for consumers: the presence of adulterated food supplements in the Netherlands

description: The use of food supplements is increasing. They are marketed as beneficial for health, well-being, physical or mental condition and performance, or to prevent diseases. Producers add synthetic compounds or illicit herbal material to food supplements to claim desired effects. Claims made to support marketing without scientific evidence are, however, illegal. Intake of adulterated food supplements may lead to serious adverse effects. The aim of this paper is to report the results of analyses of (adulterated) food supplements conducted by the Netherlands Food and Consumer Product Safety Authority between October 2013 and October 2018. In total, 416 supplements were analysed of which 264 (64%) contained one or more pharmacological active substances or plant toxins, such as caffeine, synephrine, sildenafil, icariin, sibutramine, higenamine, hordenine, phenethylamine, methylsynephrine, DMAA, phenolphthalein, octopamine and ephedrine. When compared to dose levels that are considered safe, daily doses of the substances in the food supplements were sometimes much higher, causing a risk for consumers who are unaware of the presence of these pharmacologically active substances. In many cases, neither food nor medicines legislation (easily) enables enforcement actions. This means that some products containing pharmacologically active substances (i.e. synthetic medicines and their illicit analogues), stay available on the market. An undesirable situation because for many of these substances no detailed toxicity data are available.
DOI: 10.6084/m9.figshare.8859152.v3
title: ITdataset

description: Dataset for "Inflation targeting in low-income countries: Does IT work?" (ITdataset_1, ITdataset_2, and ITdataset_3), published at Review of Development Economics
DOI: 10.6084/m9.figshare.8858888.v1
title: Figure 3 - data

description: Raw data for immunocytochemistry quantification of OCT4/RGECO staining in hiPSCs and cardiac alpha actining/RGECO staining in hiPSC-CMs
DOI: 10.6084/m9.figshare.8858330
title: Title

description: Description
DOI: 10.6084/m9.figshare.8858129
title: Supplementary Material for: <b><i>Trichophyton violaceum</i></b>: An Emerging Pathogen in Southern Switzerland

description: <b><i>Background:</i></b> <i>Trichophyton violaceum</i>is an anthropophilic dermatophyte, endemic in Africa and recently an emerging pathogen in Europe. <b><i>Objective:</i></b> To perform a retrospective analysis of dermatophytoses due to <i>T. violaceum</i> between 2007 and 2018, in order to evaluate epidemiological trends in Southern Switzerland (Ticino). <b><i>Methods:</i></b> We reviewed all medical records of patients affected by dermatophytosis due to <i>T. violaceum</i> between January 2007 and December 2018 in Bellinzona (Ticino, Switzerland). <b><i>Results:</i></b> Dermatophytoses due to <i>T. violaceum</i>was diagnosed in 44 patients, 33 of which were in the last 4 years. The most affected sex was female (25/44) and the most frequent diagnosis was tinea capitis (30/44). The majority of tinea capitis patients were children younger than 13 years of age (27/30). The main source of contagion were people from endemic areas, especially from Eritrea. <b><i>Conclusion:</i></b> In Southern Switzerland <i>T. violaceum</i>has been rarely diagnosed before 2014. Its increased occurrence seems linked to increased migratory flows from Eritrea. Since it is responsible mainly for tinea capitis, with most of the time no clearly defined alopecia patches, it is important to consider it as a possible diagnosis when facing scalp scaling. Tinea capitis due to<i> T. violaceum</i> is a benign affection, but if left untreated it can spread epidemically, especially among children in schools and kindergartens. Mycological examination is then required, not only for a correct diagnosis and epidemiological data, but also for planning the appropriate treatment.
DOI: 10.6084/m9.figshare.8858093
title: INDIANA-D4

description: INDIANA-D4
DOI: 10.6084/m9.figshare.8858105
title: Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD

description: <b>Background:</b> IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. The pathogenesis of this disease is not clear. Transcriptome analysis was performed to identify genes over- and under-expressed in patients with IgG4-RD. <b>Method:</b> DNA microarray analysis was performed using RNA from peripheral blood mononuclear cells of two patients with IgG4-RD and four healthy individuals. Genes showing a greater than threefold change in expression in IgG4-RD patients following steroid therapy were identified. Four genes related to innate immunity such as transcobalamin I (TCN1), secretory leukocyte peptidase inhibitor (SLPI), bactericidal/permeability-increasing protein (BPI) and lactotransferrin (LTF) were assessed by real-time PCR in 15 IgG4-RD patients and 13 healthy individuals. <b>Result:</b> DNA microarray analysis identified 30 genes showing a greater than threefold change in expression in IgG4-RD patients following steroid therapy. Real-time RT-PCR showed that the levels of mRNAs encoding TCNI and SLPI, except for BPI and LTF, were significantly lower in patients with IgG4-RD than in healthy people. The levels of all four mRNAs in patients with IgG4-RD were significantly increased after steroid treatment. <b>Conclusion:</b> These results indicate that reduction in expression of innate immunity-related genes may participate in the pathogenesis of IgG4-RD that steroid treatment may rectify impaired innate immunity as well as acquired immunity.
DOI: 10.6084/m9.figshare.8858114
title: Childhood war exposure and financial risk taking

description: Do-files, final dataset, and original SHARE datasets used for the analyses of the paper "<i>Childhood exposure to the Second World War and financial risk taking in adult life</i>"
DOI: 10.6084/m9.figshare.8858105.v1
title: Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD

description: <b>Background:</b> IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. The pathogenesis of this disease is not clear. Transcriptome analysis was performed to identify genes over- and under-expressed in patients with IgG4-RD. <b>Method:</b> DNA microarray analysis was performed using RNA from peripheral blood mononuclear cells of two patients with IgG4-RD and four healthy individuals. Genes showing a greater than threefold change in expression in IgG4-RD patients following steroid therapy were identified. Four genes related to innate immunity such as transcobalamin I (TCN1), secretory leukocyte peptidase inhibitor (SLPI), bactericidal/permeability-increasing protein (BPI) and lactotransferrin (LTF) were assessed by real-time PCR in 15 IgG4-RD patients and 13 healthy individuals. <b>Result:</b> DNA microarray analysis identified 30 genes showing a greater than threefold change in expression in IgG4-RD patients following steroid therapy. Real-time RT-PCR showed that the levels of mRNAs encoding TCNI and SLPI, except for BPI and LTF, were significantly lower in patients with IgG4-RD than in healthy people. The levels of all four mRNAs in patients with IgG4-RD were significantly increased after steroid treatment. <b>Conclusion:</b> These results indicate that reduction in expression of innate immunity-related genes may participate in the pathogenesis of IgG4-RD that steroid treatment may rectify impaired innate immunity as well as acquired immunity.
DOI: 10.6084/m9.figshare.8858114.v1
title: Childhood war exposure and financial risk taking

description: Do-files, final dataset, and original SHARE datasets used for the analyses of the paper "<i>Childhood exposure to the Second World War and financial risk taking in adult life</i>"
DOI: 10.6084/m9.figshare.8858093.v1
title: INDIANA-D4

description: INDIANA-D4
DOI: 10.6084/m9.figshare.8858024
title: Development of a regulatable low-temperature protein expression system using the psychrotrophic bacterium, <i>Shewanella livingstonensis</i> Ac10, as the host

description: A low-temperature protein expression system is useful for the production of thermolabile proteins. We previously developed a system that enables constitutive protein production at low temperatures, using the psychrotrophic bacterium <i>Shewanella livingstonensis</i> Ac10 as the host. To increase the utility of this system, in the present study, we introduced a repressible promoter of the <i>trp</i> operon of this bacterium into the system. When ß-lactamase was produced under the control of this promoter at 18°C and 4°C, the yields were 75 and 33 mg/L-culture, respectively, in the absence of L-Trp, and the yields were decreased by 72% and 77%, respectively, in the presence of L-Trp. We also found that 3-indoleacrylic acid, a competitive inhibitor of the <i>Escherichia coli trp</i> repressor, increased the expression of the reporter gene. This repressible gene expression system would be useful for regulatable recombinant protein production at low temperatures. A regulatable low-temperature protein expression system was constructed by using a cold-adapted bacterium as the host and its trp operon promoter.
DOI: 10.6084/m9.figshare.8858018
title: Helmstedt-Leipzig VD16+VD17+VD18 RDF dataset

description: This dataset contains Helmstedt and Leipzig data extracted from VD16, VD17, VD18 datasets in RDF format.
DOI: 10.6084/m9.figshare.8858024.v1
title: Development of a regulatable low-temperature protein expression system using the psychrotrophic bacterium, <i>Shewanella livingstonensis</i> Ac10, as the host

description: A low-temperature protein expression system is useful for the production of thermolabile proteins. We previously developed a system that enables constitutive protein production at low temperatures, using the psychrotrophic bacterium <i>Shewanella livingstonensis</i> Ac10 as the host. To increase the utility of this system, in the present study, we introduced a repressible promoter of the <i>trp</i> operon of this bacterium into the system. When ß-lactamase was produced under the control of this promoter at 18°C and 4°C, the yields were 75 and 33 mg/L-culture, respectively, in the absence of L-Trp, and the yields were decreased by 72% and 77%, respectively, in the presence of L-Trp. We also found that 3-indoleacrylic acid, a competitive inhibitor of the <i>Escherichia coli trp</i> repressor, increased the expression of the reporter gene. This repressible gene expression system would be useful for regulatable recombinant protein production at low temperatures. A regulatable low-temperature protein expression system was constructed by using a cold-adapted bacterium as the host and its trp operon promoter.
DOI: 10.6084/m9.figshare.8858003
title: Aranguren-GassisM_EcoLetters.zip

description: Original data for plots and figures on the paper Aranguren-Gassis, et al. 2019 Ecology Letters. The files include daily biomass estimations for the thermal performance curves (TPCs) assays at ~100 and ~200 generations, growth rates for the 34ºC challenge at ~200 generations, C:N ratios for the ~200 generations TPC assay and growth rates during the evolution experiment at 31ºC.
DOI: 10.6084/m9.figshare.8858012
title: Hybrid vigour for thermal tolerance in hybrids between the allopatric kelps <i>Laminaria digitata</i> and <i>L. pallida</i> (Laminariales, Phaeophyceae) with contrasting thermal affinities

description: Kelps are globally important bioengineering species with high ecological and economic value, but are increasingly threatened by climate-driven geographic range shifts. The inheritance of economically important traits from parents to offspring is poorly understood in kelps but it is of utmost interest to seaweed farmers wishing to select strains with superior performance and resilience to environmental change. For two allopatric kelp species (N-Atlantic <i>Laminaria digitata</i> and S-Atlantic <i>L. pallida</i>), we compared the speed of gametogenesis and reproductive success in parental gametophytes, and produced intraspecific and reciprocal interspecific crosses of female × male gametophyte parents isolated from the two species. We then compared the upper thermal resilience of microscopic and macroscopic sibling sporophytes in an exposure experiment over two weeks. The upper thermal limit of the sporophytes resulting from intraspecific crosses of the two species deviated by 1°C. In contrast, sporophytes from both interspecific hybrid crosses had a 2–3°C higher upper thermal tolerance than single species sporophytes, indicating heterosis for thermal tolerance. This phenotypic response appears partially sex-dependent in our study, with female parents being more important in determining the thermal-response phenotype than male parents. The presence of male gametophytes generally enhanced female reproductive success. Both gametogenesis rate and reproductive success differed among the types of reciprocal crosses. Although the interspecific crosses were artificial in an ecological sense, they may provide a tool for understanding the molecular basis of heterosis and thermal tolerance in kelps (e.g. by investigating species-specific gene expression), or for aquaculture breeding programmes against a background of rapid environmental change.
DOI: 10.6084/m9.figshare.8858003.v1
title: Aranguren-GassisM_EcoLetters.zip

description: Original data for plots and figures on the paper Aranguren-Gassis, et al. 2019 Ecology Letters. The files include daily biomass estimations for the thermal performance curves (TPCs) assays at ~100 and ~200 generations, growth rates for the 34ºC challenge at ~200 generations, C:N ratios for the ~200 generations TPC assay and growth rates during the evolution experiment at 31ºC.
DOI: 10.6084/m9.figshare.8857997
title: Additional file 9: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Sequences used for the phylogenetic analysis of the EP receptors in Fig. 2. (FASTA 41 kb)
DOI: 10.6084/m9.figshare.8858012.v2
title: Hybrid vigour for thermal tolerance in hybrids between the allopatric kelps <i>Laminaria digitata</i> and <i>L. pallida</i> (Laminariales, Phaeophyceae) with contrasting thermal affinities

description: Kelps are globally important bioengineering species with high ecological and economic value, but are increasingly threatened by climate-driven geographic range shifts. The inheritance of economically important traits from parents to offspring is poorly understood in kelps but it is of utmost interest to seaweed farmers wishing to select strains with superior performance and resilience to environmental change. For two allopatric kelp species (N-Atlantic <i>Laminaria digitata</i> and S-Atlantic <i>L. pallida</i>), we compared the speed of gametogenesis and reproductive success in parental gametophytes, and produced intraspecific and reciprocal interspecific crosses of female × male gametophyte parents isolated from the two species. We then compared the upper thermal resilience of microscopic and macroscopic sibling sporophytes in an exposure experiment over two weeks. The upper thermal limit of the sporophytes resulting from intraspecific crosses of the two species deviated by 1°C. In contrast, sporophytes from both interspecific hybrid crosses had a 2–3°C higher upper thermal tolerance than single species sporophytes, indicating heterosis for thermal tolerance. This phenotypic response appears partially sex-dependent in our study, with female parents being more important in determining the thermal-response phenotype than male parents. The presence of male gametophytes generally enhanced female reproductive success. Both gametogenesis rate and reproductive success differed among the types of reciprocal crosses. Although the interspecific crosses were artificial in an ecological sense, they may provide a tool for understanding the molecular basis of heterosis and thermal tolerance in kelps (e.g. by investigating species-specific gene expression), or for aquaculture breeding programmes against a background of rapid environmental change.
DOI: 10.6084/m9.figshare.8858018.v1
title: Helmstedt-Leipzig VD16+VD17+VD18 RDF dataset

description: This dataset contains Helmstedt and Leipzig data extracted from VD16, VD17, VD18 datasets in RDF format.
DOI: 10.6084/m9.figshare.8857997.v1
title: Additional file 9: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Sequences used for the phylogenetic analysis of the EP receptors in Fig. 2. (FASTA 41 kb)
DOI: 10.6084/m9.figshare.8858012.v1
title: Hybrid vigour for thermal tolerance in hybrids between the allopatric kelps <i>Laminaria digitata</i> and <i>L. pallida</i> (Laminariales, Phaeophyceae) with contrasting thermal affinities

description: Kelps are globally important bioengineering species with high ecological and economic value, but are increasingly threatened by climate-driven geographic range shifts. The inheritance of economically important traits from parents to offspring is poorly understood in kelps but it is of utmost interest to seaweed farmers wishing to select strains with superior performance and resilience to environmental change. For two allopatric kelp species (N-Atlantic <i>Laminaria digitata</i> and S-Atlantic <i>L. pallida</i>), we compared the speed of gametogenesis and reproductive success in parental gametophytes, and produced intraspecific and reciprocal interspecific crosses of female × male gametophyte parents isolated from the two species. We then compared the upper thermal resilience of microscopic and macroscopic sibling sporophytes in an exposure experiment over two weeks. The upper thermal limit of the sporophytes resulting from intraspecific crosses of the two species deviated by 1°C. In contrast, sporophytes from both interspecific hybrid crosses had a 2–3°C higher upper thermal tolerance than single species sporophytes, indicating heterosis for thermal tolerance. This phenotypic response appears partially sex-dependent in our study, with female parents being more important in determining the thermal-response phenotype than male parents. The presence of male gametophytes generally enhanced female reproductive success. Both gametogenesis rate and reproductive success differed among the types of reciprocal crosses. Although the interspecific crosses were artificial in an ecological sense, they may provide a tool for understanding the molecular basis of heterosis and thermal tolerance in kelps (e.g. by investigating species-specific gene expression), or for aquaculture breeding programmes against a background of rapid environmental change.
DOI: 10.6084/m9.figshare.8857991
title: Additional file 1: of The Herts and Minds study: feasibility of a randomised controlled trial of Mentalization-Based Treatment versus usual care to support the wellbeing of children in foster care

description: Results of additional measures. (ODT 12 kb)
DOI: 10.6084/m9.figshare.8858018.v2
title: Helmstedt-Leipzig VD16+VD17+VD18 RDF dataset

description: This dataset contains Helmstedt and Leipzig data extracted from VD16, VD17, VD18 datasets in RDF format.
DOI: 10.6084/m9.figshare.8857991.v1
title: Additional file 1: of The Herts and Minds study: feasibility of a randomised controlled trial of Mentalization-Based Treatment versus usual care to support the wellbeing of children in foster care

description: Results of additional measures. (ODT 12 kb)
DOI: 10.6084/m9.figshare.8858018.v4
title: Helmstedt-Leipzig VD16+VD17+VD18 RDF dataset

description: This dataset contains Helmstedt and Leipzig data extracted from VD16, VD17, VD18 datasets in RDF format.
DOI: 10.6084/m9.figshare.8857976
title: Additional file 5: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Table with ciliary beat frequency measurements of individual larvae used for Fig. 5. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8858018.v3
title: Helmstedt-Leipzig VD16+VD17+VD18 RDF dataset

description: This dataset contains Helmstedt and Leipzig data extracted from VD16, VD17, VD18 datasets in RDF format.
DOI: 10.6084/m9.figshare.8857973
title: Additional file 4: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: KS test results of the vertical distributions shown in Fig. 4. (TXT 10 kb)
DOI: 10.6084/m9.figshare.8857976.v1
title: Additional file 5: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Table with ciliary beat frequency measurements of individual larvae used for Fig. 5. (XLSX 11 kb)
DOI: 10.6084/m9.figshare.8857964
title: Additional file 3: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Individual measurements for the vertical distribution shown in Fig. 4. (XLSX 112 kb)
DOI: 10.6084/m9.figshare.8857973.v1
title: Additional file 4: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: KS test results of the vertical distributions shown in Fig. 4. (TXT 10 kb)
DOI: 10.6084/m9.figshare.8857964.v1
title: Additional file 3: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Individual measurements for the vertical distribution shown in Fig. 4. (XLSX 112 kb)
DOI: 10.6084/m9.figshare.8857943
title: Additional file 11: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Fasttree output file of the phylogenetic analysis of the EP receptors (Fig. 2). (TXT 7 kb)
DOI: 10.6084/m9.figshare.8857934
title: Additional file 10: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Alignment used for the phylogenetic analysis of the EP receptors in Fig. 2. (FASTA 31 kb)
DOI: 10.6084/m9.figshare.8857943.v1
title: Additional file 11: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Fasttree output file of the phylogenetic analysis of the EP receptors (Fig. 2). (TXT 7 kb)
DOI: 10.6084/m9.figshare.8857934.v1
title: Additional file 10: of A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus

description: Alignment used for the phylogenetic analysis of the EP receptors in Fig. 2. (FASTA 31 kb)
DOI: 10.6084/m9.figshare.8857889
title: Additional file 5: of The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce

description: Legend to lane numbers in Additional file 4. For each lane, accession name, code, and PCR result are provided. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8857889.v1
title: Additional file 5: of The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce

description: Legend to lane numbers in Additional file 4. For each lane, accession name, code, and PCR result are provided. (XLSX 12 kb)
DOI: 10.6084/m9.figshare.8857871
title: Additional file 2: of The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce

description: LsVe alleles found in this study. Provided are names of contigs or scaffolds, identical representatives included in Fig. 4, and completeness of sequencing coverage. (XLSX 15 kb)
DOI: 10.6084/m9.figshare.8857871.v1
title: Additional file 2: of The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce

description: LsVe alleles found in this study. Provided are names of contigs or scaffolds, identical representatives included in Fig. 4, and completeness of sequencing coverage. (XLSX 15 kb)