cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21340161.v2
title: Integrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors

description: Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from being fully defined. Therefore, more studies are needed to improve the current clinicopathological classification system, and advanced treatment strategies such as targeted therapy and immunotherapy are yet to be explored. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date for a cohort of 200 PitNET patients. Genomics data indicate that <em>GNAS</em> copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage. Proteomics-based classification of PitNETs identified 7 clusters, among which, tumors overexpressing epithelial-mesenchymal transition (EMT) markers clustered into a more invasive subgroup. Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion, and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration. These identified molecular markers and alternations in various clusters/subtypes were further confirmed in an independent cohort of 750 PitNET patients. This proteogenomic analysis across traditional histological boundaries improves our current understanding of PitNET pathophysiology and suggests novel therapeutic targets and strategies.
DOI: 10.5281/zenodo.7200082
title: Intermediate files for dRep / inStrain tutorial

description: Intermediate files for dRep / inStrain tutorial
DOI: 10.5281/zenodo.7200081
title: Intermediate files for dRep / inStrain tutorial

description: Intermediate files for dRep / inStrain tutorial
DOI: 10.34740/kaggle/dsv/4329921
title: OntoUML/UFO Catalog
DOI: 10.6084/m9.figshare.21340161
title: Integrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors

description: Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from being fully defined. Therefore, more studies are needed to improve the current clinicopathological classification system, and advanced treatment strategies such as targeted therapy and immunotherapy are yet to be explored. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date for a cohort of 200 PitNET patients. Genomics data indicate that <em>GNAS</em> copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage. Proteomics-based classification of PitNETs identified 7 clusters, among which, tumors overexpressing epithelial-mesenchymal transition (EMT) markers clustered into a more invasive subgroup. Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion, and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration. These identified molecular markers and alternations in various clusters/subtypes were further confirmed in an independent cohort of 750 PitNET patients. This proteogenomic analysis across traditional histological boundaries improves our current understanding of PitNET pathophysiology and suggests novel therapeutic targets and strategies.
DOI: 10.6084/m9.figshare.21340161.v3
title: Integrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors

description: Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from being fully defined. Therefore, more studies are needed to improve the current clinicopathological classification system, and advanced treatment strategies such as targeted therapy and immunotherapy are yet to be explored. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date for a cohort of 200 PitNET patients. Genomics data indicate that <em>GNAS</em> copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage. Proteomics-based classification of PitNETs identified 7 clusters, among which, tumors overexpressing epithelial-mesenchymal transition (EMT) markers clustered into a more invasive subgroup. Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion, and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration. These identified molecular markers and alternations in various clusters/subtypes were further confirmed in an independent cohort of 750 PitNET patients. This proteogenomic analysis across traditional histological boundaries improves our current understanding of PitNET pathophysiology and suggests novel therapeutic targets and strategies.
DOI: 10.34740/kaggle/dsv/4329997
title: BBC News
DOI: 10.15468/ev31zc
title: MNA CIBAN Italian Antarctic Bacterial Culture Collection

description: The Italian Collection of Antarctic Bacteria (Collezione Italiana Batteri Antarctici; CIBAN) was established in 1989 at the Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina. CIBAN is one of the few collections in the world dedicated to Antarctic bacteria and, since its inception, it has grown to include 515 cold-adapted strains belonging to 69 Genera. Many of these strains derive from the Terra Nova Bay marine area and hav been extracted from seawater, sediment, and benthic organisms. CIBAN also hosts bacterial isolates from the continent.
DOI: 10.6084/m9.figshare.21340269
title: Nighttime light data

description: It's the nighttime light data of Dezhou City.
DOI: 10.7910/dvn/3ptm2m
title: Apartment Rental Data Of University Students

description: The dataset contains Rental Data of Tenants
DOI: 10.6084/m9.figshare.21340361
title: Additional file 1 of Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21340361.v1
title: Additional file 1 of Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21340367
title: Additional file 3 of Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.21340367.v1
title: Additional file 3 of Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.21340402
title: Additional file 4 of Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020

description: Supplementary Material 4
DOI: 10.6084/m9.figshare.21340402.v1
title: Additional file 4 of Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020

description: Supplementary Material 4
DOI: 10.6084/m9.figshare.21340429
title: Additional file 1 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21340429.v1
title: Additional file 1 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 1
DOI: 10.6084/m9.figshare.21340435
title: Additional file 3 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.21340435.v1
title: Additional file 3 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.21340438.v1
title: Additional file 4 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 4
DOI: 10.6084/m9.figshare.21340438
title: Additional file 4 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 4
DOI: 10.6084/m9.figshare.21340441
title: Additional file 5 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 5
DOI: 10.6084/m9.figshare.21340441.v1
title: Additional file 5 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 5
DOI: 10.6084/m9.figshare.21340444
title: Additional file 6 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 6
DOI: 10.6084/m9.figshare.21340444.v1
title: Additional file 6 of Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

description: Supplementary Material 6
DOI: 10.6084/m9.figshare.21340453
title: Additional file 1 of Incorporating a gender lens into nutrition and health-related policies in Fiji: analysis of policies and stakeholder perspectives

description: Additional file 1: Supplementary table 1. Policy content analysis and WHO gender analysis, data extraction.
DOI: 10.6084/m9.figshare.21340453.v1
title: Additional file 1 of Incorporating a gender lens into nutrition and health-related policies in Fiji: analysis of policies and stakeholder perspectives

description: Additional file 1: Supplementary table 1. Policy content analysis and WHO gender analysis, data extraction.
DOI: 10.6084/m9.figshare.21340516
title: Additional file 3 of Creating an online educational intervention to improve knowledge about systematic reviews among healthcare workers: mixed-methods pilot study

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.21340516.v1
title: Additional file 3 of Creating an online educational intervention to improve knowledge about systematic reviews among healthcare workers: mixed-methods pilot study

description: Supplementary Material 3
DOI: 10.6084/m9.figshare.19935152
title: A New Uncertain Remanufacturing Scheduling Model with Rework Risk Using Hybrid Optimization Algorithm

description: 111111
DOI: 10.6084/m9.figshare.19935152.v2
title: A New Uncertain Remanufacturing Scheduling Model with Rework Risk Using Hybrid Optimization Algorithm

description: 111111
DOI: 10.6084/m9.figshare.19935152.v1
title: A New Uncertain Remanufacturing Scheduling Model with Rework Risk Using Hybrid Optimization Algorithm

description: As a resource-conserving and environmental-friendly manufacturing paradigm, remanufacturing with the potential to realize sustainability in production has been extensively investigated. Scheduling plays a significant role in achieving the remanufacturing benefits. However, the remanufacturing process involves intricate uncertainties because it takes end-of-life products with different qualities as workblanks, which increases the risk of rework and complicates remanufacturing scheduling. Though the traditional stochastic optimization methods or fuzzy theory have been employed to address uncertainties in the remanufacturing scheduling problem, they are constrained with the limited historical data which renders it difficult to describe uncertainties accurately and intuitively. Therefore, a new uncertain remanufacturing scheduling model with rework risk is proposed, in which, the interval grey numbers are applied to describe the uncertainty clearly and consider the rework risk in remanufacturing process. To solve this model, a hybrid optimization algorithm that combines differential evolution and particle swarm optimization algorithms through an efficient representation scheme is proposed. Besides, this algorithm integrates multiple improvements to maintain the diversity of the population and enhance its performance. Simulation experiments are given, demonstrating that the proposed algorithm provides a better optimal solution than other baseline algorithms for solving the remanufacturing scheduling problem.
DOI: 10.34620/dadosipb/1aiy2x
title: Replication Data for: A review of Europe's circular economy in the building sector

description: Support database for the review paper: A review of Europe's circular economy in the building sector
DOI: 10.34620/dadosipb/qxhm0n
title: News_Classification_Table

description: Excel file of the compiled news on the disposal of wind turbine blades with the sorting criteria that the authors applied.
DOI: 10.34740/kaggle/dsv/4330087
title: Ukraine Conflict Twitter Dataset (53.44M tweets)
DOI: 10.5281/zenodo.7203066
title: PERTEMUAN 5, 17 OKTOBER 2022, PUSAT LABA, STIESIA SURABAYA

description: <strong>Capaian Pembelajaran Mata Kuliah (CPMK)</strong> Setelah menempuh mata kulian ini mahasiswa mampu <strong>menganalisis</strong> lingkungan pengendalian manajemen, proses pengendalain manajemen dan variasi dalam pengendalain manajemen dan mampu <strong>mendesain </strong>serta mampu <strong>memanfaatkan</strong> secara optimal sistem pengendalian manajemen untuk mendukung fungsi Controller. Mahasiswa mampu memahami pusat laba, pengukuran pusat laba dan pusat laba lainnya Indikator Pembelajaran 1. Menjelaskan wewenang dan pengukuran pusat laba 2. Mengidentifikasi konsep-konsep laba yang dipakai sebagai pengukuran pusat laba
description: PERTEMUAN 5, 17 OKTOBER 2022, PUSAT LABA, STIESIA SURABAYA
DOI: 10.5281/zenodo.7203065
title: PERTEMUAN 5, 17 OKTOBER 2022, PUSAT LABA, STIESIA SURABAYA

description: <strong>Capaian Pembelajaran Mata Kuliah (CPMK)</strong> Setelah menempuh mata kulian ini mahasiswa mampu <strong>menganalisis</strong> lingkungan pengendalian manajemen, proses pengendalain manajemen dan variasi dalam pengendalain manajemen dan mampu <strong>mendesain </strong>serta mampu <strong>memanfaatkan</strong> secara optimal sistem pengendalian manajemen untuk mendukung fungsi Controller. Mahasiswa mampu memahami pusat laba, pengukuran pusat laba dan pusat laba lainnya Indikator Pembelajaran 1. Menjelaskan wewenang dan pengukuran pusat laba 2. Mengidentifikasi konsep-konsep laba yang dipakai sebagai pengukuran pusat laba
description: PERTEMUAN 5, 17 OKTOBER 2022, PUSAT LABA, STIESIA SURABAYA
DOI: 10.6084/m9.figshare.17006551.v2
title: 22222

description: 111111111
DOI: 10.6084/m9.figshare.17006551
title: 22222

description: 111111111
DOI: 10.6084/m9.figshare.17006551.v1
title: A New Remanufacturing System Scheduling Model with Diversified Reprocessing Routes Using a Hybrid Meta-heuristic Algorithm

description: This is the experimental data of the manuscript entitled "A New Remanufacturing System Scheduling Model with Diversified Reprocessing Routes Using a Hybrid Meta-heuristic Algorithm". All data are generated through computer simulation and saved in the file with csv format. The data are the simulation of the real-world case. There are seventeen instances for these experiments with various scales. The information of the datasets are shown in the csv document, including the category of end-of-life products, the number of end-of-life products, the type of damage to product components, the number of components of each type of damage and the routes they choose, the operations contained in each routes, and disassembly, reassembly, and the time spent in reprocessing each operation.
DOI: 10.5281/zenodo.7203384
title: Samoan Passage Bathymetry Data Archive

description: Samoan Passage Bathymetry Data Archive. Please note that the copy here on zenodo contains only the GitHub repository, data are stored elsewhere. Head to https://github.com/gunnarvoet/sp-data-archive-bathy for instructions on how to clone the full dataset or download data files manually at https://osf.io/7anhw/.
DOI: 10.5281/zenodo.7203383
title: Samoan Passage Bathymetry Data Archive

description: Samoan Passage Bathymetry Data Archive. Please note that the copy here on zenodo contains only the GitHub repository, data are stored elsewhere. Head to https://github.com/gunnarvoet/sp-data-archive-bathy for instructions on how to clone the full dataset or download data files manually at https://osf.io/7anhw/.
DOI: 10.6084/m9.figshare.15049410
title: Unused links

description: Unused links
DOI: 10.6084/m9.figshare.15049410.v2
title: Unused links

description: Unused links
DOI: 10.6084/m9.figshare.15049410.v1
title: Individualized requirement-driven multi-task scheduling in cloud manufacturing using an extended multifactorial evolutionary algorithm

description: This is the experimental data of the manuscript entitled "Individualized requirement-driven multi-task scheduling in cloud manufacturing using an extended multifactorial evolutionary algorithm". All data are generated through computer simulation and saved in the file with csv format. The data are the simulation of the real-world case. There are nine instances for these experiments, which cover multiple scales. Three attributes including time, cost, and reliability of servies for achieving corresponding subtasks are shown in datasets.
DOI: 10.34740/kaggle/ds/2550197
title: Apartment Rental Database of University Students
DOI: 10.24342/a3fb20a0-5fcb-4e5e-9f97-0ec4de3f0518
title: Open-source Workflow for Parameterized Electrical Machine Finite Element Computation with Elmer

description: Automatization software to solve electromagnetic problems with Elmer software. The case study involved a large amount of parameter studies related to finding the best design choices for the machine details such as the slot number, slot shapes, winding layers, rotor bar number, and rotor bar shapes. In order to solve the problems in an efficient manner, an automatized design workflow was established. The workflow presented consists of a number of existing open-source software and a new software developed to control the workflow. Software created as a part of Mäntylä's Master Thesis.
DOI: 10.6084/m9.figshare.20456790
title: Direct oral anticoagulants toxicity in children: an overview and practical guide

description: By increasing use of direct oral anticoagulants (DOACs) in adults and children, gradual increase in the number of intentional or unintentional DOAC poisonings among children is suspected in the near future. Hence, clinicians and pharmacists need to be familiar with the clinical features and management of DOAC-toxicity among pediatric population. This article provides an overview and practical guide to DOAC-toxicity in pediatrics according to the available clinical evidence. Based on limited available data, accidental pediatric ingestion of DOACs can be managed by supportive care in most cases. However, serious toxicity may occur following massive overdose, in presence of underlying disorders (renal or hepatic dysfunction) and concurrent anticoagulant therapy. Activated charcoal is recommended for known recent ingestion of DOACs (within 2–4 hours) to reduce the gastrointestinal absorption. Supportive interventions including local hemostatic measures and volume resuscitation are the cornerstone of management of bleeding. Vitamin K and fresh frozen plasma are ineffective for DOAC reversal and thus are not recommended. Currently, safety and efficacy data regarding the use of specific reversal agents (including idarucizumab and andexanet alfa) and 3-factor or 4-factor prothrombin complex concentrate (PCC) or activated PCC (aPCC) among children with DOAC-associated bleeding are lacking.
DOI: 10.6084/m9.figshare.20456790.v1
title: Direct oral anticoagulants toxicity in children: an overview and practical guide

description: By increasing use of direct oral anticoagulants (DOACs) in adults and children, gradual increase in the number of intentional or unintentional DOAC poisonings among children is suspected in the near future. Hence, clinicians and pharmacists need to be familiar with the clinical features and management of DOAC-toxicity among pediatric population. This article provides an overview and practical guide to DOAC-toxicity in pediatrics according to the available clinical evidence. Based on limited available data, accidental pediatric ingestion of DOACs can be managed by supportive care in most cases. However, serious toxicity may occur following massive overdose, in presence of underlying disorders (renal or hepatic dysfunction) and concurrent anticoagulant therapy. Activated charcoal is recommended for known recent ingestion of DOACs (within 2–4 hours) to reduce the gastrointestinal absorption. Supportive interventions including local hemostatic measures and volume resuscitation are the cornerstone of management of bleeding. Vitamin K and fresh frozen plasma are ineffective for DOAC reversal and thus are not recommended. Currently, safety and efficacy data regarding the use of specific reversal agents (including idarucizumab and andexanet alfa) and 3-factor or 4-factor prothrombin complex concentrate (PCC) or activated PCC (aPCC) among children with DOAC-associated bleeding are lacking.
DOI: 10.6084/m9.figshare.21340605
title: Untitled Item

description: sssssssssss
DOI: 10.6084/m9.figshare.21340605.v1
title: Untitled Item

description: sssssssssss
DOI: 10.6084/m9.figshare.20524941.v1
title: The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay

description: Main figures, Extended Data figures, and supplementary information
DOI: 10.6084/m9.figshare.20524941
title: The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay

description: Main figures, Extended Data figures, and supplementary information