cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.17129600.v1
title: Supplementary Material for: Radiologic response as a prognostic factor in advanced hepatocellular carcinoma with macroscopic vascular invasion after transarterial chemoembolization and radiotherapy

description: Introduction: We evaluated the radiologic response rate of combined transarterial chemoembolization (TACE) plus radiotherapy (RT) in treatment-naïve patients with liver-confined hepatocellular carcinoma (HCC) with macroscopic vascular invasion (MVI) and analyzed its clinical importance in overall survival (OS) outcomes. Methods: Patients who were treated with TACE plus RT as a first-line treatment for HCC with MVI between January 2010 and December 2015 were retrospectively reviewed. Radiologic response was assessed according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) at 2- and 4-months after completion of RT. Landmark analysis at 2- and 4-months and time-dependent Cox regression analysis using response as a time-dependent covariate were performed for univariable and multivariable analyses. Results: The 2-month landmark analysis included 427 patients, and the 4-month landmark analysis included 355 patients after excluding patients without imaging studies for response evaluation at 4 months. Radiologic responses were observed in 210 (49.2%) patients at 2 months and 181 (51.8%) at 4 months. In multivariable analyses, radiologic response was identified as an independent prognosticator for OS at 2 months (median OS: responders, 23.1 months vs. non-responders, 8.0 months; hazard ratio [HR], 3.194; P &lt; 0.001) and 4 months (median OS: responders, 26.5 months vs. non-responders, 9.3 months; HR, 4.534; P &lt; 0.001). Conclusion: Radiologic response assessed by mRECIST was a significant prognostic factor for OS in patients with advanced-stage HCC showing MVI treated with combined TACE plus RT.
DOI: 10.6084/m9.figshare.23543652.v1
title: Supplementary Material for: Disease Burden and Health Status among People with Severe Obesity Who Do Not Receive Bariatric Surgery: A Retrospective Study

description: <b><i>Introduction:</i></b> The aim of the study was to compare eligible individuals who were or were not treated with bariatric surgery and describe disease burden, treatment, and healthcare costs over 3 years in individuals who were not. <b><i>Methods:</i></b> Adults with obesity class II and comorbidities, or obesity class III, were identified in IQVIA Ambulatory EMR – US and PharMetrics<sup>®</sup> Plus administrative claims databases (January 1, 2007–December 31, 2017). Outcomes included demographics, BMI, comorbidities, and per patient per year (PPPY) healthcare costs. <b><i>Results:</i></b> Of 127,536 eligible individuals, 3,962 (3.1%) underwent surgery. The surgery group was younger, a greater proportion were women, and mean BMI and rates of some comorbidities (obstructive sleep apnea, gastroesophageal reflux disease, and depression) were higher than in the nonsurgery group. Mean healthcare costs PPPY in the baseline year were USD 13,981 in the surgery group and USD 12,024 in the nonsurgery group. In the nonsurgery group, incident comorbidities increased during follow-up. Mean total costs increased by 20.5% from baseline to year 3, mostly driven by an increase in pharmacy costs; however, fewer than 2% of these individuals initiated antiobesity medications. <b><i>Conclusions:</i></b> Individuals who did not undergo bariatric surgery showed a progressive worsening of health and increasing healthcare costs, indicating a large unmet need for access to clinically indicated obesity treatment.
DOI: 10.6084/m9.figshare.26364157.v1
title: Figure 6

description: Data from Figure 6
DOI: 10.6084/m9.figshare.28719125.v1
title: Trained SynLlama models, data for reconstruction algorithm, and reported results

description: Generative machine learning models for small molecule drug discovery have shown immense promise, but many molecules they generate are too difficult to synthesize, making them impractical for further investigation or development. In this work, we present a novel approach by fine-tuning Meta’s Llama3 large language models (LLMs) to create SynLlama, which generates full synthetic pathways made of commonly accessible building blocks and robust organic reaction templates. SynLlama explores a large synthesizable space using significantly less data compared to other state-of-the-art methods, and offers strong performance in bottom-up synthesis, synthesizable analog generation, and hit expansion, offering medicinal chemists a valuable tool for drug discovery developments. We find that SynLlama, even without training on external building blocks, can effectively generalize to unseen yet purchasable building blocks, meaning that its reconstruction capabilities extend to a broader synthesizable chemical space than the training data.
DOI: 10.6084/m9.figshare.22194646.v1
title: source data for manuscript entitled "cavity dehydration as a gating mechanism of potassium channels"

description: Source data for the manuscript entitled "cavity dehydration as a gating mechanism of potassium channels". The data for each Table and Figure are inclued in separated folders. Please see the readme file in each folder for the details.
DOI: 10.6084/m9.figshare.5306623.v1
title: Michigan Office of Civil Defense, blood type identification card No. 63 6 53528 (1938), L R Collings

description: Michigan Office of Civil Defense, blood type identification card No. 63 6 53528 (1938), L R Collings
DOI: 10.6084/m9.figshare.7285415.v1
title: Supplementary Material for: The Landscape of Non-Coding RNA in an Adult Pig Model of Intrauterine Growth Restriction

description: <b><i>Background/Aims:</i></b> Intrauterine growth restriction (IUGR) is a risk factor for adult metabolic syndrome, but how this disease is regulated by lncRNAs and circRNAs remains elusive. <b><i>Methods:</i></b> Here, we employed adult IUGR and normal pigs as models to evaluate the expression of various global lncRNAs and circRNAs in pig livers using RNA-seq. <b><i>Results:</i></b> In total, we obtained 1,162 million raw reads of approximately 104.54 Gb high quality data. After a strict five-step filtering process, 3,368 lncRNAs were identified, including 300 differentially expressed lncRNAs (<i>p</i> &lt; 0.05) in the IUGR group relative to the control group. The cis-regulatory analysis identified target genes that were enriched in specific GO terms and pathways (<i>p</i> &lt; 0.05), including amino acid metabolism, oxidoreductase activity, PPAR signaling pathway, and insulin signaling pathway. These are closely related to the observed phenotypes of increased gluconeogenesis and impaired mitochondrial oxidative phosphorylation in adulthood of the IUGR group. Additionally, we also identified 403 circRNAs, of which 44 were differentially expressed (<i>p</i> &lt; 0.05). Interestingly, our results identified ATF4-miR214-circRNA7964 and TCF7-miR22-3p-circRNA16347 as two competing endogenous networks, which were closely associated with the observed increase in hepatic gluconeogenesis in the IUGR group. <b><i>Conclusion:</i></b> Together, this study reveals a multitude of candidate lncRNAs and circRNAs involved in the development of IUGR pigs, which could facilitate further researches on the molecular mechanisms of metabolic syndrome.
DOI: 10.17632/mbnczn5rw3
title: COVID-19 Isl Dataset

description: In the dataset, lung CT images of 495 patients who were selected in accordance with the study criteria, had RT-PCR test results and had CT scans were accessed. In total, 361 of these patients were COVID-19 patients and 134 were non-COVID-19 patients. A total of 15584 lung CT slices were obtained, 8395 slices from 361 COVID-19 cases and 7189 slices from 134 non-COVID-19 cases. While the images were originally in DICOM format, they were converted to png format.
DOI: 10.17632/w2znrd28kp
title: RELCI: A program for relativistic configuration interaction calculations ☆

description: Abstract The set-up and diagonalization of (large) Hamiltonian matrices are two key elements in studying the structure and properties of many-electron atoms and ions. The efficiency in dealing with these tasks eventually determines for which atomic systems useful ab initio predictions can be made today and how accurate these predictions are. To facilitate further structure calculations, in particular for open-shell atoms and ions, here we present a new configuration interaction program in the framewor... Title of program: RELCI Catalogue Id: ADQH_v1_0 Nature of problem Approximate atomic wave functions are determined by diagonalizing the Hamiltonian matrix within an appropriate many-particle basis. Here, the construction of the configuration interaction (CI) basis follows the same principles as in the structure code GRASP92 [1] which is utilized to generate the configuration state functions (CSF) and the radial orbitals for all subshells of the given active space. Versions of this program held in the CPC repository in Mendeley Data ADQH_v1_0; RELCI; 10.1016/S0010-4655(02)00463-0 This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2019)
DOI: 10.6084/m9.figshare.7397477.v1
title: Data from: Moving microbes: the dynamics of transient microbial residence on human skin

description: These are the data files and analytical script files from: Vandegrift, Fahimipour, Muscarella, Bateman, Van Den Wymelenberg, and Bohannan. 2019. Moving microbes: the dynamics of transient microbial residence on human skin. <i>mSphere</i>.<br>
DOI: 10.6084/m9.figshare.16755214.v1
title: Figure1_ephys_data.mat

description: Dataset for figure 1 ephys
DOI: 10.17632/gnghrv3rhc
title: LINF_150018900

description: Protein of unknown function - conserved; Leishmania infantum (strain JPCM5)
DOI: 10.6084/m9.figshare.25097684.v1
title: <b>10m winter wheat harvested area and planted area distribution map of China for five years (2018-2022)</b>

description: ------ 1. Introductory information ------Title: Mapping 10-m harvested area in the major winter wheat-producing regions of China from 2018 to 2022Format: TIFNaming convention: " ChinaWheatMap10_P_2018.tif" means winter wheat planted area map of 2018, and “ChinaWheatMap10_H_2018.tif" means winter wheat harvested area map of 2018.Authors: Jinkang Hu, Dailiang Peng, Bing Zhang, Jianxi Huang, Wenjuan Zhang, Bin Zhao, Enhui Cheng, Zihang Lou, Shengwei Liu, Songlin Yang, Yunlong Tan, and Yulong LvKey Laboratory of Digital Earth Science, Aerospace Information Research Institute, Chinese Academy of SciencesCorresponding author: Bing ZhangContact Information: hujinkang21@mails.ucas.ac.cn (JK.H.); zhangbing@aircas.ac.cn (B.Z.)------ 2. Data specific information ------The dataset contains winter wheat maps of harvested area and planted area with 10m spatial resolution for five years (2018-2022) over eight provinces. In the datasets, the values equal to one means winter wheat.Software: ArcGIS, QGIS or ENVI are needed to read the dataset.
DOI: 10.17632/p4m3bpx8y6
title: Cultural ecosystem service supply-demand matching and cultural demand cluster distribution: A case study of hilly and mountainous areas in southern China

description: The location dataset of ecosystem service cultural needs was obtained from the points of interest (POIs) of China's open public platform, Gaode Map. The longitude, latitude, description, and comments of POIs were filtered based on keywords among all POIs in the study area using Python's public application programming interface (API) These datasets are publicly available, and information protected by user privacy was not captured. We pre-processed all the collected POIs with coordinate transformation and data cleaning. All POI points have been checked and we collect a total of 3614 valid poi for December 2015. Collect 7,615 valid POI points for December 2022.
DOI: 10.17632/rh5vx9cg8r
title: Texto y contexto en el análisis estilístico literario

description: Se explora la importancia del texto en el análisis estilístico literario. Se argumenta que la estilística de decodificación debe enfocarse en el texto íntegro como objeto de estudio, desglosándolo en componentes necesarios para cualquier investigación científica. Se cuestiona qué define un texto y cuáles son sus límites, sugiriendo que su tamaño y forma escrita no son determinantes. Se establece la relación entre el texto y otras unidades lingüísticas, y presenta una secuencia de niveles estilísticos, desde el gráfico hasta el textual. También se aborda cómo los diferentes niveles de análisis, incluyendo el gráfico, sonoro, léxico y sintáctico, contribuyen a la comprensión del texto. Además, destaca la analogía con el concepto matemático de multitud, donde la cantidad de elementos no afecta la definición del texto. Finalmente, se subraya la importancia del contexto en la interpretación estilística y cómo elementos como la repetición y las posiciones fuertes en el texto influyen en su coherencia y significado.
DOI: 10.6084/m9.figshare.22182904.v7
title: Supplementary Dataset, Supplementary tables 1-4, and Supplementary figure 1 for the paper: 'The “Trojan horse” strategy: seed fungal endophyte symbiosis helps to explain the invasion success of the grass Poa annua in Maritime Antarctica'

description: Supplementary dataset for the paper:<b>The “Trojan horse” strategy: seed fungal endophyte symbiosis helps to explain the invasion success of the grass </b><i><b>Poa annua</b></i><b> in Maritime Antarctica</b><b>Aim:</b><i>Poa annua </i>L. (annual bluegrass) is presently the sole invasive vascular plant species to have successfully established in Maritime Antarctica, where it poses a significant conservation threat to native plant species. However, the reasons for its success in the region have yet to be established. Here, we determined whether the invasiveness of <i>P. annua</i>, and its competitiveness with the native Antarctic hairgrass <i>Deschampsia antarctica</i>, is influenced by symbioses formed with seed fungal endophytes, and whether plants derived from seeds from four global regions differ in their performance.<b>Locations:</b>Four regions (Maritime Antarctica, sub-Antarctica, South America and Europe).<b>Methods:</b>Endophyte frequency was measured in <i>P. annua </i>seeds collected from the four regions. The germination, survival, biomass accumulation, flowering and competitiveness with <i>D. antarctica </i>of <i>P. annua </i>plants grown from endophyte-uncolonised and uncolonised seeds was determined in the laboratory. The effects of endophytes on <i>P. annua </i>seed germination and survival and seedling osmoprotection were also assessed in the Maritime Antarctic natural environment using locally-sourced seeds.<b>Results:</b>Endophytes were at least twice as frequent in seeds from Maritime Antarctica than in those from other regions. A higher proportion of endophyte-colonised seeds germinated and survived than did uncolonised seeds, but only when they originated from Maritime Antarctica.Seed endophytes increased the competitiveness of <i>P. annua </i>with <i>D. antarctica</i>, but only for plants grown from Maritime Antarctic seeds.In the field, endophyte-colonised seeds from Maritime Antarctica germinated and survived more frequently than uncolonised seeds, and osmoprotection was higher in seedlings grown from colonised seed.<b>Main conclusions:</b>The findings indicate beneficial effects of seed endophytes on invasion-related traits of <i>P. annua</i>, such as survival, germination success and flowering.Together with vegetative and reproductive traits facilitating the colonization process, the seed-fungal endophyte symbiosis can be invoked as an important factor explaining the invasiveness of <i>P. annua </i>in Maritime Antarctica.
DOI: 10.6084/m9.figshare.24223858.v1
title: Energy Simulation.zip

description: Três Marias power plant simulation
DOI: 10.6084/m9.figshare.25289308.v1
title: Data from: Recovery and degradation drive changes in the dispersal capacity of stream macroinvertebrate communities

description: Freshwater ecosystems face significant threats from various anthropogenic pressures, including pollution, habitat loss, invasive species, and climate change. To address these challenges, protective regulations and restoration efforts have been implemented at national and international levels, resulting in overall improvements in freshwater biodiversity. However, population recovery of macroinvertebrates at impacted or restored sites is greatly affected by the life-history traits and the dispersive abilities of species. This study focuses on understanding the complex relationship between the ecological quality of stream habitats and the dispersal capacity of macroinvertebrate communities in Europe. More specifically, we investigate the role of overall dispersal capacity metric, and specific dispersal traits, in shaping community recovery and degradation processes.Using a comprehensive dataset of 1,327 time series on macroinvertebrate communities ranging from 1968 to 2021 across 23 European countries, this research investigates how changes in ecological quality influence the dispersal capacity of these communities. The findings reveal that recovering sites with improving ecological quality tend to have more dispersive macroinvertebrate communities, characterized by species with more dispersive traits (e.g. active aquatic and aerial dispersers, species with frequent propensity to drift, insects with two similar-sized pair of wings or with larger wings). By contrast, degrading sites show a reduction in the proportion of strong dispersers. However, our results showed this response varied extensively among regions, and thus, some communities that have increased their ecological quality have not gained macroinvertebrates with higher dispersal capacity.This study emphasizes the importance of considering dispersal capacity when planning and implementing freshwater ecosystem restoration projects. Management strategies should focus on enhancing landscape connectivity to create accessible “source” areas and refugia for sensitive taxa, especially as climate change reshapes habitat suitability. Additionally, biodiversity initiatives must incorporate adaptive decision-making approaches that account for the site-specific responses of macroinvertebrate communities to changes in ecological quality.<br>
DOI: 10.17632/mpgwdxsm7t
title: Peripheral blood protein profiling in DLBCL

description: Quantification of 81 proteins in serum or plasma from 19 healthy blood donors and two cohorts of patients diagnosed with diffuse large B-cell lymphoma (DLBCL). The purpose of this study was to identify protein profiles associated with survival in DLBCL. The Oslo cohort comprises 51 patients, of which 18 were sampled both before and after treatment with Rituximab and chemotherapy, while the rest of the patients were only sampled before treatment. The St. Louis cohort comprises 60 patients, all of which were sampled before initiation of treatment. While EDTA plasma was sampled in the St. Louis cohort, the material obtained from healthy donors and patients in the Oslo cohort was serum. Because of this difference, data from the St. Louis cohort should not be directly compared to the data from healthy donors and Oslo cohort patients. The Normalized Protein eXpression (NPX) unit is used for all values. For this reason, values from different proteins cannot be compared. Please refer to the referenced published article for technical details, clinical information and interpretation. Data is supplied in Microsoft Excel format and as comma-separated values (CSV) files.
DOI: 10.17632/29df9nwkx4
title: Sediment-water fluxes of methane, dissolved inorganic carbon, ammonium and oxygen; sediment porosity and organic carbon content in Curonian, Vistula and Oder lagoons

description: The data file shows novel, previously unpublished data on:
- sediment-water fluxes of methane (CH4)
- sediment-water fluxes of dissolved inorganic carbon (DIC)
- sediment-water fluxes of ammonium (NH4+)
- sediment-water fluxes of oxygen (O2)
- sedimentary porosity
- sedimentary organic carbon content (Corg)
collected from three European lagoons (Curonian, Vistula and Oder) between 2021 and 2023.
DOI: 10.17632/dhh6mbjky5
title: Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP

description: Raw data files associated with:
Salmonella invasion of a cell is self limiting due to effector-driven activation of N-WASP.
Davidson et. al 2023, iScience
DOI: 10.17632/stxdn5cjhh
title: Psycho-spiritual challenges faced by palliative health care providers in Bangladesh: A multicenter-based descriptive cross-sectional study

description: Background: Palliative care providers play a crucial role in supporting patients with life-limiting illnesses by emphasizing the alleviation of suffering and enhancing quality of life. The intrinsic nature of palliative care, which often involves confronting death and dying, places considerable emotional and spiritual demands on caregivers. Psycho-spirituality, an integration of psychological well-being and spiritual dimensions, is vital for these providers to maintain their mental health and provide holistic care to their patients. Despite its importance, empirical studies focusing on the psycho-spiritual experiences of palliative care providers are limited. Method: This multicenter-based, descriptive cross-sectional study aims to explore the psycho-spiritual challenges faced by palliative care providers. Data was collected from 160 licensed healthcare providers, through face-to-face semi-structured interviews conducted from August to September 2022. Result: The results indicate that younger healthcare providers (aged 20-39) report higher psychological stress compared to their older counterparts (p = 0.029). Males exhibited slightly higher stress levels than females (p = 0.036), and divorced individuals reported the highest stress levels (p = 0.01). Educational qualification (p = 0.017), and income levels (p = 0.001) showed significant correlations with spiritual status with higher educational attainment and income associated with better spiritual well-being. Doctors experienced higher psychological stress (p = 0.004) but also reported higher spiritual status compared to nurses and other healthcare workers. Conclusion: The findings depict significant associations between sociodemographic factors and the psychospiritual well-being of healthcare providers. Understanding these associations is crucial for developing targeted interventions to support the well-being of palliative care providers, ultimately leading to better patient care outcomes. Future research should focus on expanding the scope.
DOI: 10.6084/m9.figshare.3201427.v2
title: acute pulmonary embolism database.xlsx

description: In the excel “1-NO;2-YES”, dataset used for the article “The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30-day mortality in patients with acute pulmonary embolism”
DOI: 10.17632/4bw3cs6h5n
title: Data for: Paleohydrological changes in southeastern China since 13 ka BP based on a multi-proxy peat record

description: Paleohydrological changes in southeastern China since 13 ka BP based on a multi-proxy peat record