cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28099938.v1
title: Development of Immediate Release Tablet Formulations of Lornoxicam with Hot Melt Extrusion Based Three-Dimensional Printing Technology

description: This study aims to develop immediate release tablet formulations of lornoxicam (LRX) using hot melt extrusion (HME)-based fused deposition modelling (FDM) focusing on the adjustment of drug release by arranging infill densities and evaluating microcrystalline cellulose II (MCC II) as a disintegrating agent for HME-FDM purposes. LRX is a poorly soluble drug that exhibits pH-dependent solubility with a high thermal degradation temperature. These characteristics make it an ideal model drug for the HME-based FDM technique. Various filament formulations were extruded using an extruder, and suitable filaments were used to produce 3D-printed tablets. Filaments and tablets were characterized. Dissolution studies were performed on tablets with different infill densities. DSC, FTIR, XRD, and SEM analyses were conducted. Although the solubility of LRX increases with pH, disintegrating agents such as MCC II had a more significant effect on the dissolution of LRX than sodium bicarbonate, which was used as the alkalinizing pore-forming agent. Dissolution studies revealed that the dissolution of LRX was enhanced by tablet erosion. Tablet erosion increased as the infill density decreased, and an immediate release profile was reached with tablets having 25% infill density. Despite the availability of conventional immediate release LRX tablets, this newly developed formulation offers the potential to be modulated for personalized theraphy via the 3D printing technique. This study demonstrates the feasibility of HME-based FDM printing technology for producing immediate-release LRX tablets with consistent quality, highlighting the utilization of MCC II as a disintegrating agent that enhances LRX dissolution in this process.
DOI: 10.5517/ccdc.csd.cc21zrg8
title: CCDC 1906390: Experimental Crystal Structure Determination

description: Related Article: Oleksandra Veselska, Ahmad Abdallah, Alexis Giraudon, Chloé Andrade, Saly Hawila, Nathalie Guillou, Erwann Jeanneau, Miguel Monge, Adel Mesbah, Alexandra Fateeva, Stéphane Pailhès, Gilles Ledoux, Florent Perret, Aude Demessence|2025|Chem.Commun.|61|977|doi:10.1039/D4CC06171C
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.6084/m9.figshare.28071778
title: A novel inhibitory strategy of <i>Leishmania major</i> using <i>Kluyveromyces lactis</i> and <i>Saccharomyces cerevisiae</i> killer toxins

description: Leishmaniasis is a globally prevalent parasitic disease that has drawn significant attention. Killer yeasts offer a novel biological control method, presenting a potential alternative for treating leishmaniasis. This study evaluates the antileishmanial activity of <i>Kluyveromyces lactis</i> and <i>Saccharomyces cerevisiae</i> killer toxins against <i>Leishmania major</i>. Killer yeasts were isolated using the Well method. The genes encoding K2 and K.L killer toxins were identified by PCR, and the toxins were purified via SDS-PAGE. Antileishmanial and cytotoxic effects on <i>L. major</i> promastigotes and amastigotes were evaluated using the MTT assay. The first killer isolate was identified as <i>Saccharomyces cerevisiae</i> ZBAM (GenBank accession: OQ376749.1) and the second as <i>Kluyveromyces lactis</i> ZBAM (GenBank accession: OQ401036.1). IC50 values of K2 and K.L toxins against <i>L. major</i> promastigotes were significantly lower than Glucantime and Amphotericin B. The EC50 values at 24 hours for Glucantime, K2, and K.L were 11.83 ± 0.02 μg/ml, 2.35 ± 0.01 μg/ml, and 3.23 ± 0.03 μg/ml, respectively. The EC50 values for K2 and K.L against <i>L. major</i> amastigotes were also lower than Glucantime. This is the first report of the antileishmanial effects of K2 and K.L toxins against <i>L. major</i>, suggesting these yeasts as promising candidates for biological leishmaniasis treatment.
DOI: 10.6084/m9.figshare.28071778.v1
title: A novel inhibitory strategy of <i>Leishmania major</i> using <i>Kluyveromyces lactis</i> and <i>Saccharomyces cerevisiae</i> killer toxins

description: Leishmaniasis is a globally prevalent parasitic disease that has drawn significant attention. Killer yeasts offer a novel biological control method, presenting a potential alternative for treating leishmaniasis. This study evaluates the antileishmanial activity of <i>Kluyveromyces lactis</i> and <i>Saccharomyces cerevisiae</i> killer toxins against <i>Leishmania major</i>. Killer yeasts were isolated using the Well method. The genes encoding K2 and K.L killer toxins were identified by PCR, and the toxins were purified via SDS-PAGE. Antileishmanial and cytotoxic effects on <i>L. major</i> promastigotes and amastigotes were evaluated using the MTT assay. The first killer isolate was identified as <i>Saccharomyces cerevisiae</i> ZBAM (GenBank accession: OQ376749.1) and the second as <i>Kluyveromyces lactis</i> ZBAM (GenBank accession: OQ401036.1). IC50 values of K2 and K.L toxins against <i>L. major</i> promastigotes were significantly lower than Glucantime and Amphotericin B. The EC50 values at 24 hours for Glucantime, K2, and K.L were 11.83 ± 0.02 μg/ml, 2.35 ± 0.01 μg/ml, and 3.23 ± 0.03 μg/ml, respectively. The EC50 values for K2 and K.L against <i>L. major</i> amastigotes were also lower than Glucantime. This is the first report of the antileishmanial effects of K2 and K.L toxins against <i>L. major</i>, suggesting these yeasts as promising candidates for biological leishmaniasis treatment.
DOI: 10.6084/m9.figshare.28081544
title: Activity of extracts and isolated compounds <i>Trichilia catigua</i> against clinically relevant <i>candida</i> species

description: To evaluate the <i>in</i> <i>vitro</i> antifungal activity of extracts and compounds from <i>Trichilia catigua</i> against clinically relevant <i>Candida</i> species, notably <i>Candida glabrata</i>, and investigate possible mechanisms of action using electron microscopy and <i>in silico</i> techniques. Extracts and fractions of <i>T.</i> <i>catigua</i> were obtained through turboextraction and partitioning, while the isolated compounds were previously purified. The ethyl acetate fraction (EAF) was characterized by HPLC. Antifungal activity against <i>C.</i> <i>glabrata</i> was evaluated through MIC tests, synergism was assessed via checkerboard assays, and structural changes were analyzed via electron microscopy. Molecular docking was performed to identify potential targets of action. The EAF and isolated compounds (cinchonains and procyanidin B2) exhibited significant activity against <i>C.</i> <i>glabrata</i>, with MICs of 9.76 µg/mL (EAF) and 3.9 µg/mL (cinchonains Ia and Ib). Cinchonain Ib combined with epicatechin or procyanidin B2 displayed synergistic effects, particularly with amphotericin B. Microscopy analysis revealed cell membrane damage, and reverse docking analysis suggested that the compounds may target an enzyme essential to the metabolic processes of <i>C.</i> <i>glabrata</i>. The findings suggest that compounds isolated from <i>T.</i> <i>catigua</i> hold considerable potential for developing new antifungal agents against <i>Candida</i> species, particularly <i>C.</i> <i>glabrata</i>, with promising safety and synergistic profiles. We wanted to see if a tree from Brazil, called “catuaba,” could help stop the fungus <i>Candida</i>. This fungus can make people very sick, especially in hospitals. Some medicines don’t work against <i>Candida</i> anymore, so we investigated catuaba extracts as an alternative treatment. We tested the bark from the catuaba tree to see if it could stop the fungus. We found that parts of the tree can stop the fungus from growing. When mixed these tree parts with established medicines, it worked even better and killed the fungus faster. We also found out that “catuaba” does not hurt healthy cells. Our findings suggest promise of these extracts to be used in future medicines.
DOI: 10.6084/m9.figshare.28081544.v1
title: Activity of extracts and isolated compounds <i>Trichilia catigua</i> against clinically relevant <i>candida</i> species

description: To evaluate the <i>in</i> <i>vitro</i> antifungal activity of extracts and compounds from <i>Trichilia catigua</i> against clinically relevant <i>Candida</i> species, notably <i>Candida glabrata</i>, and investigate possible mechanisms of action using electron microscopy and <i>in silico</i> techniques. Extracts and fractions of <i>T.</i> <i>catigua</i> were obtained through turboextraction and partitioning, while the isolated compounds were previously purified. The ethyl acetate fraction (EAF) was characterized by HPLC. Antifungal activity against <i>C.</i> <i>glabrata</i> was evaluated through MIC tests, synergism was assessed via checkerboard assays, and structural changes were analyzed via electron microscopy. Molecular docking was performed to identify potential targets of action. The EAF and isolated compounds (cinchonains and procyanidin B2) exhibited significant activity against <i>C.</i> <i>glabrata</i>, with MICs of 9.76 µg/mL (EAF) and 3.9 µg/mL (cinchonains Ia and Ib). Cinchonain Ib combined with epicatechin or procyanidin B2 displayed synergistic effects, particularly with amphotericin B. Microscopy analysis revealed cell membrane damage, and reverse docking analysis suggested that the compounds may target an enzyme essential to the metabolic processes of <i>C.</i> <i>glabrata</i>. The findings suggest that compounds isolated from <i>T.</i> <i>catigua</i> hold considerable potential for developing new antifungal agents against <i>Candida</i> species, particularly <i>C.</i> <i>glabrata</i>, with promising safety and synergistic profiles. We wanted to see if a tree from Brazil, called “catuaba,” could help stop the fungus <i>Candida</i>. This fungus can make people very sick, especially in hospitals. Some medicines don’t work against <i>Candida</i> anymore, so we investigated catuaba extracts as an alternative treatment. We tested the bark from the catuaba tree to see if it could stop the fungus. We found that parts of the tree can stop the fungus from growing. When mixed these tree parts with established medicines, it worked even better and killed the fungus faster. We also found out that “catuaba” does not hurt healthy cells. Our findings suggest promise of these extracts to be used in future medicines.
DOI: 10.5517/ccdc.csd.cc2f9bgk
title: CCDC 2243298: Experimental Crystal Structure Determination

description: Related Article: Ramavath Vinodkumar, Ashwini K. Nakate, Gamidi Rama Krishna, Ravindar Kontham|2025|Chem.Commun.|61|973|doi:10.1039/D4CC05546B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f9bhl
title: CCDC 2243299: Experimental Crystal Structure Determination

description: Related Article: Ramavath Vinodkumar, Ashwini K. Nakate, Gamidi Rama Krishna, Ravindar Kontham|2025|Chem.Commun.|61|973|doi:10.1039/D4CC05546B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2f9bjm
title: CCDC 2243300: Experimental Crystal Structure Determination

description: Related Article: Ramavath Vinodkumar, Ashwini K. Nakate, Gamidi Rama Krishna, Ravindar Kontham|2025|Chem.Commun.|61|973|doi:10.1039/D4CC05546B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.hqdbpm
title: Occurrence Download

description: A dataset containing 31 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Agrostemma githago L., Agrostemma githago f. exilis Bolzon, Agrostemma githago f. nicaeensis (Roth) Hegi, Agrostemma githago var. alba H.Mart., Agrostemma githago var. killiasii Brügger, Agrostemma githago var. linicola (Terechov) K.Hammer, Agrostemma githago var. macrospermum (Levina) K.Hammer, Agrostemma githago var. microcalyx Döll, Agrostemma githago var. minor Cout., Agrostemma githago var. minor Zapal., Agrostemma githago var. nanum Hartm., Agrostemma githago var. nicaeense Willd., Agrostemma githago var. nicaeensis (Pers.) Rouy & Foucaud, Agrostemma gitthago Retz., Agrostemma hirsutum Gilib., Agrostemma hirsutum Stokes, Agrostemma infestum Salisb., Agrostemma linicola Terechov, Agrostemma macrospermum Levina, Agrostemma nicaeense Pers., Agrostemma nicaeensis Pers., Agrostemma nicaeensis Roth, Githago nicaeensis (Roth) Link, Githago segetalis St.-Lag., Githago segetum Link, Githago segetum var. nanum Lunell, Lychnis agrostemma Ledeb., Lychnis githago (L.) Scop., Lychnis githago var. nicaeensis Willd., Lychnis githago var. nicaensis DC., Lychnis nicaeensis (Roth) G.Don, Lychnis segetalis St.-Lag., Lychnis segetum Lam., Silene githago (L.) Clairv., Silene githago (L.) E.H.L.Krause)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen, Machine Observation)"
 ]
 }
 },
 "Geometry POLYGON((16.26355 48.15358,16.48014 48.15358,16.48014 48.27418,16.26355 48.27418,16.26355 48.15358))",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2024",
 "Month is greater than or equal to January",
 "Month is less than or equal to September"
 ]
}

 The dataset includes 31 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019315-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2f9bkn
title: CCDC 2243301: Experimental Crystal Structure Determination

description: Related Article: Ramavath Vinodkumar, Ashwini K. Nakate, Gamidi Rama Krishna, Ravindar Kontham|2025|Chem.Commun.|61|973|doi:10.1039/D4CC05546B
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.18419/darus-4345
title: Data for: A systematic DNS approach to isolate wall-curvature effects in spatially developing boundary layers

description: Spanwise [z] and temporal [t] averaged turbulent fields of four direct numerical simulations (DNS) of a turbulent boundary layer (TBL) calculated using the code NS3D. Datasets ZPG-C & ZPG-F both have approximately zero pressure gradient along the wall boundary, whereas PG-C & PG-F have a nearly identical non-zero pressure gradient. Both ZPG-C and PG-C have the same curved (C) wall shape and ZPG-F and PG-F are flat (F) plate TBLs. See publication for a full description of the study design. The data are stored in HDF5 containers in which 2D and 1D datasets are present, along with grid coordinates and characteristic freestream conditions of the cases.
description: More detailed information about the data can be found in the readme.md
DOI: 10.18419/darus-4345/1
title: ztmd_zpgf.xmf2

description: ParaView XML companion file for ztmd_zpgf.h5
DOI: 10.18419/darus-4345/14
title: readme.md

description: README in markdown format with HDF5 file contents description
DOI: 10.18419/darus-4345/15
title: readme.pdf

description: Markdown readme.md exported as .pdf
DOI: 10.18419/darus-4345/2
title: ztmd_zpgc.h5

description: HDF5 data file for case ZPG-C
DOI: 10.18419/darus-4345/3
title: ztmd_pgf.xmf2

description: ParaView XML companion file for ztmd_pgf.h5
DOI: 10.18419/darus-4345/4
title: ztmd_pgc.h5

description: HDF5 data file for case PG-C
DOI: 10.18419/darus-4345/5
title: ztmd_zpgf.h5

description: HDF5 data file for case ZPG-F
DOI: 10.18419/darus-4345/6
title: ztmd_pgc.xmf2

description: ParaView XML companion file for ztmd_pgc.h5
DOI: 10.18419/darus-4345/7
title: ztmd_zpgc.xmf2

description: ParaView XML companion file for ztmd_zpgc.h5
DOI: 10.18419/darus-4345/8
title: example_access_data_h5py.py

description: Example script for how to access data in python using h5py API
DOI: 10.18419/darus-4345/9
title: ztmd_pgf.h5

description: HDF5 data file for case PG-F
DOI: 10.15468/dl.dj5wmw
title: Occurrence Download

description: A dataset containing 28 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Phakellia hirondellei Topsent, 1890"
 ]
}

 The dataset includes 28 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019317-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8ja5r8
title: Occurrence Download

description: A dataset containing 2398 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Machine Observation, Human Observation)",
 "Continent is one of (North America, South America)",
 "Country is one of (Brazil, Mexico, Colombia, Ecuador, Bolivia (Plurinational State of), Guatemala, Peru, Costa Rica, Belize, Argentina)",
 "DatasetKey is iNaturalist Research-grade Observations",
 "OccurrenceStatus is Present",
 "TaxonKey is Panthera onca (Linnaeus, 1758)"
 ]
}

 The dataset includes 2398 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019316-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nnauwt
title: Occurrence Download

description: A dataset containing 6860 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Pan troglodytes (Blumenbach, 1775)"
 ]
}

 The dataset includes 6860 records from 107 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019318-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x75kep
title: Occurrence Download

description: A dataset containing 36836 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Australia",
 "OccurrenceStatus is Present",
 "TaxonKey is Rhinella marina (Linnaeus, 1758)"
 ]
}

 The dataset includes 36836 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019319-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.8g2gzh
title: Occurrence Download

description: A dataset containing 905 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rhizostoma octopus (Gmelin, 1791)",
 "Year 2020-2025"
 ]
}

 The dataset includes 905 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019320-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h23qq8
title: Occurrence Download

description: A dataset containing 534 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Brazil",
 "TaxonKey is Sweetia fruticosa Spreng."
 ]
}

 The dataset includes 534 records from 101 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019321-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.9t8cvg
title: Occurrence Download

description: A dataset containing 154690 species occurrences available in GBIF matching the query:
{
 "and" : [
 "FamilyKey is Lauraceae",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is Specimen",
 "Continent is Asia"
 ]
}

 The dataset includes 154690 records from 189 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019293-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.34740/kaggle/dsv/10685246
title: The Proton Smash-Up Data⚛️⚛️⚛️
DOI: 10.15468/dl.srzweb
title: Occurrence Download

description: A dataset containing 123242 species occurrences available in GBIF matching the query:
{
 "and" : [
 "FamilyKey is Fagaceae",
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is Specimen",
 "Continent is Asia"
 ]
}

 The dataset includes 123242 records from 227 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019299-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pgkedb
title: Occurrence Download

description: A dataset containing 65080 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Thunnus albacares (Bonnaterre, 1788)",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "Year is greater than or equal to 2000",
 "Year is less than or equal to 2025"
 ]
}

 The dataset includes 65080 records from 78 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019322-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4uwmq5
title: Occurrence Download

description: A dataset containing 36836 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Australia",
 "OccurrenceStatus is Present",
 "TaxonKey is Rhinella marina (Linnaeus, 1758)"
 ]
}

 The dataset includes 36836 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019324-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.g48t4v
title: Occurrence Download

description: A dataset containing 18611 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Desmophyllum pertusum (Linnaeus, 1758)"
 ]
}

 The dataset includes 18611 records from 77 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019325-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ckxk6c
title: Occurrence Download

description: A dataset containing 572300 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Annonaceae)"
 ]
}

 The dataset includes 572300 records from 1625 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0019289-250127130748423/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.