cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.21992059
title: Study on the correlation between maternal serum uric acid and foetal birth weight in Naqu, Tibet

description: In high-altitude regions, low birth weight is mainly caused by hypoxia. We aimed to determine whether maternal serum uric acid (SUC) level was associated with decreased foetal birth weight. The relevant data of individual pregnant women who delivered between 37 and 40 weeks in the People’s Hospital of Naqu City, Tibet were retrospectively collected. The correlation between maternal SUC and birth weight was examined using multivariate linear regression analysis and subgroup analysis. The results showed that there was a significant negative correlation between SUC and birth weight in pregnant women with proteinuria, female foetuses, and primiparas. Fitting smoothing curve analysis showed that there was a negative linear correlation between SUC and birth weight in primiparas and female foetuses. Maternal SUC is negatively associated with foetal birth weight in a single pregnancy with proteinuria, primipara, or female foetuses in the Naqu region of Tibet, China.IMPACT STATEMENT<b>What is already known on this subject?</b> Preeclampsia associated with hyperuricaemia can affect foetal birth weight, foetal birth weight in plains area is negatively correlated with maternal hyperuricaemia.<b>What do the results of this study add?</b> Maternal SUC was negatively correlated with foetal birth weight, especially in primipara, mothers with proteinuria, and pregnant girls.<b>What are the implications of these findings for clinical practice and/or further research?</b> The results suggest that attention should be paid to SUC in pregnant women, especially in primipara, mothers with proteinuria, and pregnant girls, in the prevention of low birth weight infants in Naqu Plateau area of Tibet. <b>What is already known on this subject?</b> Preeclampsia associated with hyperuricaemia can affect foetal birth weight, foetal birth weight in plains area is negatively correlated with maternal hyperuricaemia. <b>What do the results of this study add?</b> Maternal SUC was negatively correlated with foetal birth weight, especially in primipara, mothers with proteinuria, and pregnant girls. <b>What are the implications of these findings for clinical practice and/or further research?</b> The results suggest that attention should be paid to SUC in pregnant women, especially in primipara, mothers with proteinuria, and pregnant girls, in the prevention of low birth weight infants in Naqu Plateau area of Tibet.
DOI: 10.6084/m9.figshare.21992059.v1
title: Study on the correlation between maternal serum uric acid and foetal birth weight in Naqu, Tibet

description: In high-altitude regions, low birth weight is mainly caused by hypoxia. We aimed to determine whether maternal serum uric acid (SUC) level was associated with decreased foetal birth weight. The relevant data of individual pregnant women who delivered between 37 and 40 weeks in the People’s Hospital of Naqu City, Tibet were retrospectively collected. The correlation between maternal SUC and birth weight was examined using multivariate linear regression analysis and subgroup analysis. The results showed that there was a significant negative correlation between SUC and birth weight in pregnant women with proteinuria, female foetuses, and primiparas. Fitting smoothing curve analysis showed that there was a negative linear correlation between SUC and birth weight in primiparas and female foetuses. Maternal SUC is negatively associated with foetal birth weight in a single pregnancy with proteinuria, primipara, or female foetuses in the Naqu region of Tibet, China.IMPACT STATEMENT<b>What is already known on this subject?</b> Preeclampsia associated with hyperuricaemia can affect foetal birth weight, foetal birth weight in plains area is negatively correlated with maternal hyperuricaemia.<b>What do the results of this study add?</b> Maternal SUC was negatively correlated with foetal birth weight, especially in primipara, mothers with proteinuria, and pregnant girls.<b>What are the implications of these findings for clinical practice and/or further research?</b> The results suggest that attention should be paid to SUC in pregnant women, especially in primipara, mothers with proteinuria, and pregnant girls, in the prevention of low birth weight infants in Naqu Plateau area of Tibet. <b>What is already known on this subject?</b> Preeclampsia associated with hyperuricaemia can affect foetal birth weight, foetal birth weight in plains area is negatively correlated with maternal hyperuricaemia. <b>What do the results of this study add?</b> Maternal SUC was negatively correlated with foetal birth weight, especially in primipara, mothers with proteinuria, and pregnant girls. <b>What are the implications of these findings for clinical practice and/or further research?</b> The results suggest that attention should be paid to SUC in pregnant women, especially in primipara, mothers with proteinuria, and pregnant girls, in the prevention of low birth weight infants in Naqu Plateau area of Tibet.
DOI: 10.6084/m9.figshare.21696601
title: Analysis of prognostic factors for cervical mucinous adenocarcinoma and establishment and validation a nomogram: a SEER-based study

description: Up to now, there are no relevant studies on prognostic factors of cervical mucinous adenocarcinoma. Therefore, we explored the prognostic factors for cervical mucinous adenocarcinoma, and established and validated the prognostic model using the SEER database. We selected the independent factors through univariate and multivariate analyses. LASSO regression analysis was conducted to identify potential risk factors. In conjunction with LASSO and multivariate analysis, the nomogram incorporated three variables, including age, tumour size, and AJCC stage for OS. The c-index was 0.794 and 0.831 in development and validated cohorts, indicating that this prediction model showed adequate discriminative ability in the development cohort. Besides, calibration curves showed good concordance for the development cohort, as well as the validation cohort. We constructed a first-of-its-kind nomogram to predict cervical mucinous adenocarcinomas OS and it showed better performance than AJCC and FIGO stages. Patients with cervical mucinous adenocarcinoma might benefit from using this model to develop tailored treatments.IMPACT STATEMENT<b>What is already known on this subject?</b> Cervical cancer has a variety of pathological types. The biological behaviour of each type is different, and the prognosis is quite different.<b>What do the results of this study add?</b> We analysed and explored the relevant factors affecting the prognosis of cervical mucinous adenocarcinoma.<b>What are the implications of these findings for clinical practice and/or further research?</b> Through the analysis of the SEER dataset, the prognostic factors affecting cervical mucinous adenocarcinoma were identified, and the first predictive model was created to predict the prognosis to help doctors develop individualised treatment plans and follow-up plans. <b>What is already known on this subject?</b> Cervical cancer has a variety of pathological types. The biological behaviour of each type is different, and the prognosis is quite different. <b>What do the results of this study add?</b> We analysed and explored the relevant factors affecting the prognosis of cervical mucinous adenocarcinoma. <b>What are the implications of these findings for clinical practice and/or further research?</b> Through the analysis of the SEER dataset, the prognostic factors affecting cervical mucinous adenocarcinoma were identified, and the first predictive model was created to predict the prognosis to help doctors develop individualised treatment plans and follow-up plans.
DOI: 10.6084/m9.figshare.21696601.v1
title: Analysis of prognostic factors for cervical mucinous adenocarcinoma and establishment and validation a nomogram: a SEER-based study

description: Up to now, there are no relevant studies on prognostic factors of cervical mucinous adenocarcinoma. Therefore, we explored the prognostic factors for cervical mucinous adenocarcinoma, and established and validated the prognostic model using the SEER database. We selected the independent factors through univariate and multivariate analyses. LASSO regression analysis was conducted to identify potential risk factors. In conjunction with LASSO and multivariate analysis, the nomogram incorporated three variables, including age, tumour size, and AJCC stage for OS. The c-index was 0.794 and 0.831 in development and validated cohorts, indicating that this prediction model showed adequate discriminative ability in the development cohort. Besides, calibration curves showed good concordance for the development cohort, as well as the validation cohort. We constructed a first-of-its-kind nomogram to predict cervical mucinous adenocarcinomas OS and it showed better performance than AJCC and FIGO stages. Patients with cervical mucinous adenocarcinoma might benefit from using this model to develop tailored treatments.IMPACT STATEMENT<b>What is already known on this subject?</b> Cervical cancer has a variety of pathological types. The biological behaviour of each type is different, and the prognosis is quite different.<b>What do the results of this study add?</b> We analysed and explored the relevant factors affecting the prognosis of cervical mucinous adenocarcinoma.<b>What are the implications of these findings for clinical practice and/or further research?</b> Through the analysis of the SEER dataset, the prognostic factors affecting cervical mucinous adenocarcinoma were identified, and the first predictive model was created to predict the prognosis to help doctors develop individualised treatment plans and follow-up plans. <b>What is already known on this subject?</b> Cervical cancer has a variety of pathological types. The biological behaviour of each type is different, and the prognosis is quite different. <b>What do the results of this study add?</b> We analysed and explored the relevant factors affecting the prognosis of cervical mucinous adenocarcinoma. <b>What are the implications of these findings for clinical practice and/or further research?</b> Through the analysis of the SEER dataset, the prognostic factors affecting cervical mucinous adenocarcinoma were identified, and the first predictive model was created to predict the prognosis to help doctors develop individualised treatment plans and follow-up plans.
DOI: 10.6084/m9.figshare.22341484
title: HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes

description: This study investigated the role of LncRNA HOTAIR knockdown in the biological impacts on cervical cancer cells. The HOTAIR gene in two human cervical cancer cell lines was silenced with small interfering (si) RNA siHOTAIR. Proliferation, apoptosis, migration and invasion of cells were assessed following the knockdown. The expressions of Notch1, EpCAM, E-cadherin, vimentin and STAT3 were assessed using qRT-PCR and Western blotting analysis. Compared with controls, HOTAIR levels were reduced significantly, the OD values of cells were significantly decreased in proliferation assays, cell apoptosis was significantly increased, cell migration and invasion were significantly reduced after HOTAIR knockdown. Molecular analysis showed that Notch1, EpCAM, vimentin and STAT3 expressions were decreased significantly, while the expression of E-cadherin was significantly increased after HOTAIR knockdown. Rescue experiments further confirmed that Notch1 and STAT3 were involved in siHOTAIR-mediated reduction of migration and invasion of cervical cancer cells.IMPACT STATEMENT<b>What is already known on this subject?</b> Long non-coding RNAs including HOTAIR, is implicated in occurrence and development of cancer and have been explored to develop new therapeutic options for cancer.<b>What do the results of this study add?</b> HOTAIR silencing significantly reduces the viability and migration ability of cells and induces cell apoptosis, adding experimental data supporting the potential use of HOTAIR specific-siRNA as a therapeutic avenue for the cancer.<b>What are the implications of these findings for clinical practice and/or further research?</b> The finding from this study would help develop clinically applicable therapeutic avenues for the cancer and identify new treatment targets in the relevant pathways leading to new drugs or treatments. <b>What is already known on this subject?</b> Long non-coding RNAs including HOTAIR, is implicated in occurrence and development of cancer and have been explored to develop new therapeutic options for cancer. <b>What do the results of this study add?</b> HOTAIR silencing significantly reduces the viability and migration ability of cells and induces cell apoptosis, adding experimental data supporting the potential use of HOTAIR specific-siRNA as a therapeutic avenue for the cancer. <b>What are the implications of these findings for clinical practice and/or further research?</b> The finding from this study would help develop clinically applicable therapeutic avenues for the cancer and identify new treatment targets in the relevant pathways leading to new drugs or treatments.
DOI: 10.6084/m9.figshare.22341484.v1
title: HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes

description: This study investigated the role of LncRNA HOTAIR knockdown in the biological impacts on cervical cancer cells. The HOTAIR gene in two human cervical cancer cell lines was silenced with small interfering (si) RNA siHOTAIR. Proliferation, apoptosis, migration and invasion of cells were assessed following the knockdown. The expressions of Notch1, EpCAM, E-cadherin, vimentin and STAT3 were assessed using qRT-PCR and Western blotting analysis. Compared with controls, HOTAIR levels were reduced significantly, the OD values of cells were significantly decreased in proliferation assays, cell apoptosis was significantly increased, cell migration and invasion were significantly reduced after HOTAIR knockdown. Molecular analysis showed that Notch1, EpCAM, vimentin and STAT3 expressions were decreased significantly, while the expression of E-cadherin was significantly increased after HOTAIR knockdown. Rescue experiments further confirmed that Notch1 and STAT3 were involved in siHOTAIR-mediated reduction of migration and invasion of cervical cancer cells.IMPACT STATEMENT<b>What is already known on this subject?</b> Long non-coding RNAs including HOTAIR, is implicated in occurrence and development of cancer and have been explored to develop new therapeutic options for cancer.<b>What do the results of this study add?</b> HOTAIR silencing significantly reduces the viability and migration ability of cells and induces cell apoptosis, adding experimental data supporting the potential use of HOTAIR specific-siRNA as a therapeutic avenue for the cancer.<b>What are the implications of these findings for clinical practice and/or further research?</b> The finding from this study would help develop clinically applicable therapeutic avenues for the cancer and identify new treatment targets in the relevant pathways leading to new drugs or treatments. <b>What is already known on this subject?</b> Long non-coding RNAs including HOTAIR, is implicated in occurrence and development of cancer and have been explored to develop new therapeutic options for cancer. <b>What do the results of this study add?</b> HOTAIR silencing significantly reduces the viability and migration ability of cells and induces cell apoptosis, adding experimental data supporting the potential use of HOTAIR specific-siRNA as a therapeutic avenue for the cancer. <b>What are the implications of these findings for clinical practice and/or further research?</b> The finding from this study would help develop clinically applicable therapeutic avenues for the cancer and identify new treatment targets in the relevant pathways leading to new drugs or treatments.
DOI: 10.5066/p13667mu
title: Public-supply and industrial water withdrawals from the Sparta aquifer by parish in Louisiana, 2023

description: Since 1975, annual water use for Louisiana has been published on a 5-year basis and is used for a variety of purposes. As the Sparta aquifer is a heavily used aquifer, is the sole source of groundwater for many parishes in Louisiana, and recent withdrawals have exceeded the Sparta’s natural recharge, a more frequent compilation of water usage for the Sparta aquifer in Louisiana is needed to inform State conservation groups and efforts, private and public entities, and to feed groundwater models.

This data release contains water withdrawn for public supply, thermoelectric, and industrial use from the Sparta aquifer in 2023, tabulated by parish and water-use category. The estimated public-supply withdrawals in 2023 from the Sparta aquifer in Louisiana were 34 million gallons per day (Mgal/d) and industrial water was 21 Mgal/d, totaling to approximately 55 Mgal/d. There were no withdrawals for power generation.
DOI: 10.6084/m9.figshare.22303097.v1
title: Vaginal microecological changes of different degrees of cervical lesions in Hakka women in Meizhou City

description: Research shows an association between vaginal microbiota and the development of cervical cancer, but the role of altered microbiota in cancer development remains controversial. In this study, we attempted to reveal the vaginal microecological changes in cervical lesions by 16S rRNA gene sequencing. Vaginal secretions were collected from Hakka women in Meizhou City, Guangdong Province, China. The diversity, composition and the correlations among species of the vaginal microbiota were determined by sequencing the bacterial 16S rRNA gene. The microbial functional abundance was detected via KEGG and COG (Clusters of Orthologous Groups). The results showed that the Cancer group was characterised by evident changes in the composition of the vaginal microbiota, increased alpha diversity, and altered community structure distribution and microbial interaction network. Linear discriminant analysis (LDA) effect size showed that 21 bacterial species were abundant in the Cancer group. In addition, the loss of <i>Lactobacillus</i> stimulated other flora proliferation, resulting in a microecological disturbance. KEGG and COG analysis indicated the cancer group is mainly concentrated in energy metabolism. In short, the vaginal microecology of Hakka women in Meizhou City presents with different degrees of cervical lesions, and the flora imbalance is an important factor in the development of cervical cancer.IMPACT STATEMENT<b>What is already known on this subject?</b> Cervical cancer is one of the most common gynecological malignancies worldwide and has become a prominent public health problem.<b>What the results of this study add?</b> Our study showed that the type of vaginal community status of Hakka women in Meizhou area was characterised by L. Iners predominates, and the gradual loss of Lactobacillus dominance in vaginal bacteria is key to microecological imbalance.<b>What the implications are of these findings for clinical practice and/or further research?</b> Disturbances in vaginal microecology can stimulate energy metabolism and lipid metabolism to induce cervical cancer development. <b>What is already known on this subject?</b> Cervical cancer is one of the most common gynecological malignancies worldwide and has become a prominent public health problem. <b>What the results of this study add?</b> Our study showed that the type of vaginal community status of Hakka women in Meizhou area was characterised by L. Iners predominates, and the gradual loss of Lactobacillus dominance in vaginal bacteria is key to microecological imbalance. <b>What the implications are of these findings for clinical practice and/or further research?</b> Disturbances in vaginal microecology can stimulate energy metabolism and lipid metabolism to induce cervical cancer development.
DOI: 10.6084/m9.figshare.22303097
title: Vaginal microecological changes of different degrees of cervical lesions in Hakka women in Meizhou City

description: Research shows an association between vaginal microbiota and the development of cervical cancer, but the role of altered microbiota in cancer development remains controversial. In this study, we attempted to reveal the vaginal microecological changes in cervical lesions by 16S rRNA gene sequencing. Vaginal secretions were collected from Hakka women in Meizhou City, Guangdong Province, China. The diversity, composition and the correlations among species of the vaginal microbiota were determined by sequencing the bacterial 16S rRNA gene. The microbial functional abundance was detected via KEGG and COG (Clusters of Orthologous Groups). The results showed that the Cancer group was characterised by evident changes in the composition of the vaginal microbiota, increased alpha diversity, and altered community structure distribution and microbial interaction network. Linear discriminant analysis (LDA) effect size showed that 21 bacterial species were abundant in the Cancer group. In addition, the loss of <i>Lactobacillus</i> stimulated other flora proliferation, resulting in a microecological disturbance. KEGG and COG analysis indicated the cancer group is mainly concentrated in energy metabolism. In short, the vaginal microecology of Hakka women in Meizhou City presents with different degrees of cervical lesions, and the flora imbalance is an important factor in the development of cervical cancer.IMPACT STATEMENT<b>What is already known on this subject?</b> Cervical cancer is one of the most common gynecological malignancies worldwide and has become a prominent public health problem.<b>What the results of this study add?</b> Our study showed that the type of vaginal community status of Hakka women in Meizhou area was characterised by L. Iners predominates, and the gradual loss of Lactobacillus dominance in vaginal bacteria is key to microecological imbalance.<b>What the implications are of these findings for clinical practice and/or further research?</b> Disturbances in vaginal microecology can stimulate energy metabolism and lipid metabolism to induce cervical cancer development. <b>What is already known on this subject?</b> Cervical cancer is one of the most common gynecological malignancies worldwide and has become a prominent public health problem. <b>What the results of this study add?</b> Our study showed that the type of vaginal community status of Hakka women in Meizhou area was characterised by L. Iners predominates, and the gradual loss of Lactobacillus dominance in vaginal bacteria is key to microecological imbalance. <b>What the implications are of these findings for clinical practice and/or further research?</b> Disturbances in vaginal microecology can stimulate energy metabolism and lipid metabolism to induce cervical cancer development.
DOI: 10.5281/zenodo.16541480
title: Modeling Human Cognitive Biases in GPT-Based Conversational Agents
DOI: 10.5281/zenodo.16541481
title: Modeling Human Cognitive Biases in GPT-Based Conversational Agents
DOI: 10.15468/dl.4cr6a8
title: Occurrence Download

description: A dataset containing 15 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Romania",
 "OccurrenceStatus is Present",
 "TaxonKey is Myocastor coypus"
 ]
}

 The dataset includes 15 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0055988-250827131500795/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.