cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29242364
title: Figure 2B

description: A-C. Fibroblasts (MRC-5 or HDF) and ARPE-19 were transduced with lentivirus expressing UL88 or vector and subjected to puromycin selection. Cells were harvested for either WB or RNA analysis. A. MRC-5 cells expressing either vector or UL88 were analysed by western blot and probed for MyD88, UL88, and tubulin. Graph shows MyD88 protein levels quantified by densitometry analysis from 4 independent experiments. Results are shown as mean ± SD. *p&lt;0.05. B. Cell lysates from HDFs expressing GFP vector, GFP-UL88, vector, or UL88, were analysed by western blot and probed for MyD88 and tubulin. C. Cell lysates from ARPE-19 cells expressing GFP vector or GFP-UL88 were analysed by western blot and probed for GFP, UL88, MyD88, and tubulin. D. Cells expressing either GFP-vector or GFP-UL88 were stimulated with IL-1β for 6 hours. Cells were fixed in PFA and stained for p65-NF-KB (red), GFP (green), and DAPI (blue). Cells were imaged on the confocal. E. At least ten different fields were images for each sample. The number of nuclei and NF-KB positive nuclei were counted. The percentage of NF-KB positive nuclei is graphed.
DOI: 10.6084/m9.figshare.29242364.v1
title: Figure 2B

description: A-C. Fibroblasts (MRC-5 or HDF) and ARPE-19 were transduced with lentivirus expressing UL88 or vector and subjected to puromycin selection. Cells were harvested for either WB or RNA analysis. A. MRC-5 cells expressing either vector or UL88 were analysed by western blot and probed for MyD88, UL88, and tubulin. Graph shows MyD88 protein levels quantified by densitometry analysis from 4 independent experiments. Results are shown as mean ± SD. *p&lt;0.05. B. Cell lysates from HDFs expressing GFP vector, GFP-UL88, vector, or UL88, were analysed by western blot and probed for MyD88 and tubulin. C. Cell lysates from ARPE-19 cells expressing GFP vector or GFP-UL88 were analysed by western blot and probed for GFP, UL88, MyD88, and tubulin. D. Cells expressing either GFP-vector or GFP-UL88 were stimulated with IL-1β for 6 hours. Cells were fixed in PFA and stained for p65-NF-KB (red), GFP (green), and DAPI (blue). Cells were imaged on the confocal. E. At least ten different fields were images for each sample. The number of nuclei and NF-KB positive nuclei were counted. The percentage of NF-KB positive nuclei is graphed.
DOI: 10.6084/m9.figshare.29242106
title: Figure 1H

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29242106.v1
title: Figure 1H

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29242367
title: Figure 2C

description: A-C. Fibroblasts (MRC-5 or HDF) and ARPE-19 were transduced with lentivirus expressing UL88 or vector and subjected to puromycin selection. Cells were harvested for either WB or RNA analysis. A. MRC-5 cells expressing either vector or UL88 were analysed by western blot and probed for MyD88, UL88, and tubulin. Graph shows MyD88 protein levels quantified by densitometry analysis from 4 independent experiments. Results are shown as mean ± SD. *p&lt;0.05. B. Cell lysates from HDFs expressing GFP vector, GFP-UL88, vector, or UL88, were analysed by western blot and probed for MyD88 and tubulin. C. Cell lysates from ARPE-19 cells expressing GFP vector or GFP-UL88 were analysed by western blot and probed for GFP, UL88, MyD88, and tubulin. D. Cells expressing either GFP-vector or GFP-UL88 were stimulated with IL-1β for 6 hours. Cells were fixed in PFA and stained for p65-NF-KB (red), GFP (green), and DAPI (blue). Cells were imaged on the confocal. E. At least ten different fields were images for each sample. The number of nuclei and NF-KB positive nuclei were counted. The percentage of NF-KB positive nuclei is graphed.
DOI: 10.6084/m9.figshare.29242367.v1
title: Figure 2C

description: A-C. Fibroblasts (MRC-5 or HDF) and ARPE-19 were transduced with lentivirus expressing UL88 or vector and subjected to puromycin selection. Cells were harvested for either WB or RNA analysis. A. MRC-5 cells expressing either vector or UL88 were analysed by western blot and probed for MyD88, UL88, and tubulin. Graph shows MyD88 protein levels quantified by densitometry analysis from 4 independent experiments. Results are shown as mean ± SD. *p&lt;0.05. B. Cell lysates from HDFs expressing GFP vector, GFP-UL88, vector, or UL88, were analysed by western blot and probed for MyD88 and tubulin. C. Cell lysates from ARPE-19 cells expressing GFP vector or GFP-UL88 were analysed by western blot and probed for GFP, UL88, MyD88, and tubulin. D. Cells expressing either GFP-vector or GFP-UL88 were stimulated with IL-1β for 6 hours. Cells were fixed in PFA and stained for p65-NF-KB (red), GFP (green), and DAPI (blue). Cells were imaged on the confocal. E. At least ten different fields were images for each sample. The number of nuclei and NF-KB positive nuclei were counted. The percentage of NF-KB positive nuclei is graphed.
DOI: 10.6084/m9.figshare.29242136
title: Figure 1I

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29242136.v1
title: Figure 1I

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29242346
title: Figure 1E

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29242346.v1
title: Figure 1E

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.25345/c5w669n1n
title: MassIVE MSV000098194 - IL17-producing gamma T cells modulate murine tissue fibrosis through stromal cell interactions
title: Tissue injury responses are governed by dynamic immune-stromal crosstalk that can promote productive tissue repair or drive dysregulated extracellular matrix (ECM) production and aberrant vascular remodeling, culminating in fibrosis. Here, we investigate how gamma T cells interact with stromal cells to shape tissue fibrosis using a preclinical model of the biomaterial foreign body response that induces a reproducible, dense fibrotic encapsulation. A mixed population of tissue-resident and migratory gamma delta T cells, consisting of type-1 (gamma delta IFN gamma) and multiple type-17 (gamma delta 17) effector subsets, accumulated at the biomaterial implantation site during the early inflammatory phase of wound healing. While the gamma delta IFN gamma later contracted as tissue fibrosis progressed, the activated gamma delta 17 persisted and served as a dominant source of interleukin (IL)-17. Aging and exposure to a high-fat diet, both factors associated with chronic inflammation and pathological fibrosis, further heightened the gamma delta 17 response. The gamma delta 17 secreted bioactive factors that stimulated fibroblast expression of pro-inflammatory and collagen genes in a Transwell co-culture assay. Computational inference of intercellular communication further linked cytokines and growth factors expressed by gamma delta T cells to the activation of fibroblast and endothelial cell transcription factors involved in ECM remodeling and vascular development, respectively. The elimination of gamma delta T cells with a TCR delta knockout strain resulted in differential expression of ECM and skeletal muscle components as well as altered blood vessel structure within the fibrotic matrix. Altogether, our results propose that signaling from gamma delta T cells can affect stromal cell phenotypes, ultimately influencing the composition and vascularity of fibrotic tissue.
DOI: 10.6084/m9.figshare.29241953
title: Figure 1F

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29241953.v1
title: Figure 1F

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05
DOI: 10.6084/m9.figshare.29241956.v1
title: Figure 1G

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05<br>
DOI: 10.6084/m9.figshare.29241956
title: Figure 1G

description: A. Protein lysates were harvested from fibroblasts infected with TB40/E wild type (WT), UL88-deficient, or UL88Rev HCMV at MOI of 3 at 96hpi. Blots were probed for viral proteins UL88, pp28, and tubulin as a loading control. Protein lysates from fibroblasts, either mock-infected or infected with wild type (WT) or UL88-STOP TB40/E strain of HCMV at a MOI of 0.05, were harvested at (B) 15 dpi or (C) 12dpi. The lysates were analysed by western blot (WB) and probed for MyD88, JAK1, NF-kB, IRF3, IRF1, p-STAT1, STAT1, EAA1, pp28, and tubulin. B-C. Graphs show densitometry analysis from 3 independent experiments for each set at 12 dpi. D. Protein lysates were harvested from fibroblasts infected with either UL88Revertant or UL88GalK virus at a low MOI of 0.05 and harvested at 12 dpi. Lysates were analysed by western blot and probed for MyD88 and tubulin (loading control). E. RNA was harvested at 12 dpi from fibroblasts infected with WT or UL88-STOP virus at low MOI of 0.05. MyD88 mRNA levels were analysed by RT-qPCR and normalized to GAPDH. Fold changes are shown from three independent experiments. Results are shown as mean ± SD. *p&lt;0.05<br>
DOI: 10.15468/dl.6pmg36
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Gomphonema truncatum Ehrenberg, 1832",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((30.0251 -31.3959,30.5701 -30.7329,30.5701 -28.5786,25.5395 -28.5786,25.5395 -32.9007,28.2048 -32.9007,28.5753 -32.6569,29.4902 -31.7517,30.0251 -31.3959))"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044522-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bxwunh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Crassula gemmifera Friedrich",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "BasisOfRecord is one of (Specimen, Living Specimen, Observation, Human Observation, Machine Observation, Material sample, Literature Occurrence, Material citation, Occurrence evidence)",
 "Geometry POLYGON ((20.2855 -34.7533,20.509 -34.5676,20.509 -32.9007,17.7723 -32.9007,17.8156 -33.0786,18.3471 -33.7176,18.3748 -33.8287,18.2181 -34.0492,18.3197 -34.3408,18.4452 -34.429,18.5435 -34.4213,18.5872 -34.3667,18.5363 -34.167,18.7345 -34.1508,18.7216 -34.3637,18.7808 -34.4521,19.0289 -34.4206,19.0831 -34.4835,19.2655 -34.5017,19.2032 -34.6157,19.2394 -34.6926,19.375 -34.6963,19.6091 -34.8524,19.8251 -34.8396,19.9798 -34.9064,20.1081 -34.8731,20.1517 -34.7847,20.2855 -34.7533))"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044523-250525065834625/datasets/export for details.
DOI: 10.15151/esrf-es-2183498757
title: PROTEINS RELATED TO PATHOGENESIS OF DISEASES, VIRAL PROTEINS, CELL DIVISION, SIGNALLING AND CHROMATIN PROCESSES

description: The outstanding research questions of our BAG (now expanded to 9 PIs) focus on proteins and their complexes involved in a variety of processes, ranging from cell homeostasis (from gene regulation to folding quality control, from energy metabolism to signal transduction) to communication and surface recognition (including trans-interactions between cell adhesion molecules, components of the extracellular matrix weaving, as well as antigen-antibody interactions for vaccine development and optimization). Key to several projects is the characterization of the mechanisms associated to enzyme function in various organisms, including bacteria, viruses, plants, animals and humans for downstream drug discovery campaigns. Emphasis is also given to research focusing on engineering protein and enzymes for future industrial applications, as well as to understand the impact of pathogenic mutations on protein structures, providing a genotype-to-molecular phenotype rationale to disease development.
DOI: 10.15468/dl.dk6tfm
title: Occurrence Download

description: A dataset containing 65585 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Genista scorpius (L.) DC.",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 65585 records from 318 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044513-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mgv3tx
title: Occurrence Download

description: A dataset containing 2 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "OccurrenceStatus is Present",
 "TaxonKey is Stenocercus scapularis (Boulenger, 1901)"
 ]
}

 The dataset includes 2 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044525-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.w9v7u5
title: Occurrence Download

description: A dataset containing 34929 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is Human Observation",
 "Continent is North America",
 "TaxonKey is Lythrum salicaria L."
 ]
}

 The dataset includes 34929 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0044524-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.