cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.7284/114470
title: Multiplexed data collected during research cruise KN219 using a WHOI Calliope instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114467
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise KN219 using a Hawaii UHDAS instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114468
title: CTD (Conductivity, Temperature, Depth) data collected during research cruise KN219 using a Sea-Bird SBE-911+ instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114472
title: Fluorometer data collected during research cruise KN219 using a WET Labs WETStar instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114471
title: GNSS (Global Navigation Satellite System) data collected during research cruise KN219 using a C&C C-Nav 2000 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114469
title: Meteorological Station data collected during research cruise KN219 using a Vaisala WXT520 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114474
title: Meteorological Station data collected during research cruise KN219 using a Vaisala WXT520 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114475
title: Radiometer data collected during research cruise KN219 using a Eppley PIR instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114476
title: Radiometer data collected during research cruise KN219 using a Eppley PSP instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114477
title: Water Temperature data collected during research cruise KN219 using a Sea-Bird SBE-48 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114473
title: TSG (Thermosalinograph) data collected during research cruise KN219 using a Sea-Bird SBE-45 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114480
title: Multiplexed data collected during research cruise KN220-01 using a WHOI Calliope instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498835
title: Data for Plos One.xlsx

description: Raw data from each of the tested specimens.
DOI: 10.7284/114478
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise KN220-01 using a Hawaii UHDAS instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114482
title: Fluorometer data collected during research cruise KN220-01 using a WET Labs WETStar instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114481
title: GNSS (Global Navigation Satellite System) data collected during research cruise KN220-01 using a C&C C-Nav 2000 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114479
title: Meteorological Station data collected during research cruise KN220-01 using a Vaisala WXT520 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114484
title: Meteorological Station data collected during research cruise KN220-01 using a Vaisala WXT520 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114485
title: Radiometer data collected during research cruise KN220-01 using a Eppley PIR instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114486
title: Radiometer data collected during research cruise KN220-01 using a Eppley PSP instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114487
title: Water Temperature data collected during research cruise KN220-01 using a Sea-Bird SBE-48 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114483
title: TSG (Thermosalinograph) data collected during research cruise KN220-01 using a Sea-Bird SBE-45 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498169
title: Meihui_Li_et_al. Alternative treatments of compensatory base changes on an ITS2 phylogeny of Corydalis (Papaveraceae)-supplemental_data.rar

description: Li et al. "<b>Alternative treatments of compensatory base changes on an ITS2 phylogeny of <i>Corydalis</i> (Papaveraceae)"supplemental file, including (1)DNA model vs RNA model tree; (2) MP-ML-BI-DNA tree; (3) DNA vs RNA model test; (4) MCMC-phase results</b>
DOI: 10.6084/m9.figshare.7498175
title: LINE-1 and <i>EPAS1</i> DNA methylation associations with high-altitude exposure

description: Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variation in altitude-adaptive phenotypes. Current and past environments may also play a role, and one way to determine the effect of the environment is through the epigenome. To characterize if Andean adaptive responses to high altitude have an epigenetic component, we analyzed DNA methylation of the promoter region of <i>EPAS1</i> and LINE-1 repetitive element among 572 Quechua individuals from high- (4,388 m) and low-altitude (0 m) in Peru. Participants recruited at high altitude had lower <i>EPAS1</i> DNA methylation and higher LINE-1 methylation. Altitude of birth was associated with higher LINE-1 methylation, not with <i>EPAS1</i> methylation. The number of years lived at high altitude was negatively associated with <i>EPAS1</i> methylation and positively associated with LINE-1 methylation. We found four one-carbon metabolism SNPs (<i>MTHFD1</i> rs2236225, <i>TYMS</i> rs502396, <i>FOLH1</i> rs202676, <i>GLDC</i> rs10975681) that cumulatively explained 11.29% of the variation in average LINE-1 methylation. And identified an association between LINE-1 methylation and genome-wide SNP principal component 1 that distinguishes European from Indigenous American ancestry suggesting that European admixture decreases LINE-1 methylation. Our results indicate that both current and lifetime exposure to high-altitude hypoxia have an effect on <i>EPAS1</i> and LINE-1 methylation among Andean Quechua, suggesting that epigenetic modifications may play a role in high-altitude adaptation.
DOI: 10.6084/m9.figshare.7498178
title: Identification and epigenetic analysis of divergent long non-coding RNAs in multilineage differentiation of human Neural Progenitor Cells

description: Long non-coding RNAs have emerged as an important regulatory layer in biological systems. Of the various types of lncRNAs, one class (designated as divergent RNAs/XH), which is in head-to-head overlap with the coding genes, has emerged as a critical biotype that regulates development and cellular differentiation. This work aimed to analyze previously published data on differential expression, epigenetic and network analysis in order to demonstrate the association of divergent lncRNAs, a specific biotype with the differentiation of human neural progenitor cells (hNPCs). We have analyzed various available RNAseq databases that address the neuronal and astrocytic differentiation of hNPCs and identified differentially expressed lncRNAs (DELs) during cell-fate determination. Key DELs identified from the databases were experimentally verified by us in our <i>in-vitro</i> hNPC differentiation system. We also analyzed the change in promoter activity using ChIP-seq datasets of the histone markers H3K4me3 (activation) and H3K27me3 (inactivation) of these DELs. Additionally, we explored the change in the euchromatinization state of DELs (by analyzing DNase-seq data) during lineage-specific differentiation of hNPCs and performed their network analysis. We were able to identify differences between neuronal and astrocytic differentiation of hNPCs at the level of divergent DELs epigenetic markers, DNAase hypersensitive sites and gene expression network. Divergent lncRNAs are more involved in neuronal rather than astrocytic differentiation, while the sense downstream lncRNA biotype appears to be more involved in astrocytic differentiation. By studying the lncRNA involvement of distinct biotypes, we have been able to indicate the preferential role of a particular biotype during lineage-specific differentiation.
DOI: 10.7284/114490
title: Multiplexed data collected during research cruise KN220-02 using a WHOI Calliope instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498178.v1
title: Identification and epigenetic analysis of divergent long non-coding RNAs in multilineage differentiation of human Neural Progenitor Cells

description: Long non-coding RNAs have emerged as an important regulatory layer in biological systems. Of the various types of lncRNAs, one class (designated as divergent RNAs/XH), which is in head-to-head overlap with the coding genes, has emerged as a critical biotype that regulates development and cellular differentiation. This work aimed to analyze previously published data on differential expression, epigenetic and network analysis in order to demonstrate the association of divergent lncRNAs, a specific biotype with the differentiation of human neural progenitor cells (hNPCs). We have analyzed various available RNAseq databases that address the neuronal and astrocytic differentiation of hNPCs and identified differentially expressed lncRNAs (DELs) during cell-fate determination. Key DELs identified from the databases were experimentally verified by us in our <i>in-vitro</i> hNPC differentiation system. We also analyzed the change in promoter activity using ChIP-seq datasets of the histone markers H3K4me3 (activation) and H3K27me3 (inactivation) of these DELs. Additionally, we explored the change in the euchromatinization state of DELs (by analyzing DNase-seq data) during lineage-specific differentiation of hNPCs and performed their network analysis. We were able to identify differences between neuronal and astrocytic differentiation of hNPCs at the level of divergent DELs epigenetic markers, DNAase hypersensitive sites and gene expression network. Divergent lncRNAs are more involved in neuronal rather than astrocytic differentiation, while the sense downstream lncRNA biotype appears to be more involved in astrocytic differentiation. By studying the lncRNA involvement of distinct biotypes, we have been able to indicate the preferential role of a particular biotype during lineage-specific differentiation.
DOI: 10.6084/m9.figshare.7498166
title: Accompanying Tables for 'Representing Women, Women Representing' Article

description: Tables accompanying the European Journal of Politics & Gender article 'Representing Women, Women Representing: Backbenchers' Questions during Prime Minister's Questions, 1979-2010' by Stephen Bates (Birmingham) & Alison Sealey (Lancaster).<br>
DOI: 10.6084/m9.figshare.7498169.v1
title: Meihui_Li_et_al. Alternative treatments of compensatory base changes on an ITS2 phylogeny of Corydalis (Papaveraceae)-supplemental_data.rar

description: Li et al. "<b>Alternative treatments of compensatory base changes on an ITS2 phylogeny of <i>Corydalis</i> (Papaveraceae)"supplemental file, including (1)DNA model vs RNA model tree; (2) MP-ML-BI-DNA tree; (3) DNA vs RNA model test; (4) MCMC-phase results</b>
DOI: 10.6084/m9.figshare.7498175.v2
title: LINE-1 and <i>EPAS1</i> DNA methylation associations with high-altitude exposure

description: Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variation in altitude-adaptive phenotypes. Current and past environments may also play a role, and one way to determine the effect of the environment is through the epigenome. To characterize if Andean adaptive responses to high altitude have an epigenetic component, we analyzed DNA methylation of the promoter region of <i>EPAS1</i> and LINE-1 repetitive element among 572 Quechua individuals from high- (4,388 m) and low-altitude (0 m) in Peru. Participants recruited at high altitude had lower <i>EPAS1</i> DNA methylation and higher LINE-1 methylation. Altitude of birth was associated with higher LINE-1 methylation, not with <i>EPAS1</i> methylation. The number of years lived at high altitude was negatively associated with <i>EPAS1</i> methylation and positively associated with LINE-1 methylation. We found four one-carbon metabolism SNPs (<i>MTHFD1</i> rs2236225, <i>TYMS</i> rs502396, <i>FOLH1</i> rs202676, <i>GLDC</i> rs10975681) that cumulatively explained 11.29% of the variation in average LINE-1 methylation. And identified an association between LINE-1 methylation and genome-wide SNP principal component 1 that distinguishes European from Indigenous American ancestry suggesting that European admixture decreases LINE-1 methylation. Our results indicate that both current and lifetime exposure to high-altitude hypoxia have an effect on <i>EPAS1</i> and LINE-1 methylation among Andean Quechua, suggesting that epigenetic modifications may play a role in high-altitude adaptation.
DOI: 10.7284/114488
title: ADCP (Acoustic Doppler Current Profiler) data collected during research cruise KN220-02 using a Hawaii UHDAS instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498145
title: Supplementary Material for: Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

description: Both high-fat diets (HFD) and bisphenol A (BPA), an environmental endocrine disruptor, are prevalent in industrialized societies. Previous studies have detected separate effects of BPA and HFD; however, none have assessed possible interactive effects. Here, pregnant dams consumed 0, 40, or 400 µg BPA/kg/day and were fed either a control (CON; 15.8% kcal fat) or HFD (45% kcal fat) from gestational day 2 through parturition. The pups were individually dosed with BPA from postnatal days (P) 1–10, while the dams continued to consume one of the two diets. Maternal behavior increased with the HFD while the offspring’s periadolescent social play decreased with BPA, but no interactive effects were observed. Neither HFD nor BPA exposure changed performance on a social recognition task, and only BPA had an effect on the elevated plus maze. BPA increased several cytokines in the medial prefrontal cortex (mPFC) of P10 males but not females. Expression of several genes related to hormone synthesis and receptors, inflammation, oxidative stress, and apoptosis in the mPFC on P10 and P90 were altered due to BPA and/or HFD exposure with rare interactive effects. BPA resulted in an increase in the gene expression of <i>Esr1</i> in the mPFC of females on both P10 and P90. Epigenetic analysis on P90 did not show a change in methylation<i></i> or in the levels of pre-mRNA or microRNA. Thus, perinatal BPA and HFD have separate effects but rarely interact.
DOI: 10.6084/m9.figshare.7498175.v1
title: LINE-1 and <i>EPAS1</i> DNA Methylation Associations with High-Altitude Exposure

description: Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variation in altitude-adaptive phenotypes. Current and past environments may also play a role, and one way to determine the effect of the environment is through the epigenome. To characterize if Andean adaptive responses to high altitude have an epigenetic component, we analyzed DNA methylation of the promoter region of <i>EPAS1</i> and LINE-1 repetitive element among 572 Quechua individuals from high- (4,388 m) and low-altitude (0 m) in Peru. Participants recruited at high altitude had lower <i>EPAS1</i> DNA methylation and higher LINE-1 methylation. Altitude of birth was associated with higher LINE-1 methylation, not with <i>EPAS1</i> methylation. The number of years lived at high altitude was negatively associated with <i>EPAS1</i> methylation and positively associated with LINE-1 methylation. We found four one-carbon metabolism SNPs (<i>MTHFD1</i> rs2236225, <i>TYMS</i> rs502396, <i>FOLH1</i> rs202676, <i>GLDC</i> rs10975681) that cumulatively explained 11.29% of the variation in average LINE-1 methylation. And identified an association between LINE-1 methylation and genome-wide SNP principal component 1 that distinguishes European from Indigenous American ancestry suggesting that European admixture decreases LINE-1 methylation. Our results indicate that both current and lifetime exposure to high-altitude hypoxia have an effect on <i>EPAS1</i> and LINE-1 methylation among Andean Quechua, suggesting that epigenetic modifications may play a role in high-altitude adaptation.
DOI: 10.7284/114492
title: Fluorometer data collected during research cruise KN220-02 using a WET Labs WETStar instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498166.v2
title: Accompanying Tables for 'Representing Women, Women Representing' Article

description: Tables accompanying the European Journal of Politics & Gender article 'Representing Women, Women Representing: Backbenchers' Questions during Prime Minister's Questions, 1979-2010' by Stephen Bates (Birmingham) & Alison Sealey (Lancaster).<br>
DOI: 10.7284/114491
title: GNSS (Global Navigation Satellite System) data collected during research cruise KN220-02 using a C&C C-Nav 2000 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498166.v4
title: Accompanying Tables for 'Representing Women, Women Representing' Article

description: Tables accompanying the European Journal of Politics & Gender article 'Representing Women, Women Representing: Backbenchers' Questions during Prime Minister's Questions, 1979-2010' by Stephen Bates (Birmingham) & Alison Sealey (Lancaster).<br>
DOI: 10.6084/m9.figshare.7498103
title: Supplementary Material for: Common and Dissociable Contributions of Alexithymia and Autism to Domain-Specific Interoceptive Dysregulations: A Dimensional Neuroimaging Approach

description: Medicine
DOI: 10.6084/m9.figshare.7498166.v3
title: Accompanying Tables for 'Representing Women, Women Representing' Article

description: Tables accompanying the European Journal of Politics & Gender article 'Representing Women, Women Representing: Backbenchers' Questions during Prime Minister's Questions, 1979-2010' by Stephen Bates (Birmingham) & Alison Sealey (Lancaster).<br>
DOI: 10.7284/114489
title: Meteorological Station data collected during research cruise KN220-02 using a Vaisala WXT520 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7498103.v1
title: Supplementary Material for: Common and Dissociable Contributions of Alexithymia and Autism to Domain-Specific Interoceptive Dysregulations: A Dimensional Neuroimaging Approach

description: Medicine
DOI: 10.7284/114494
title: Meteorological Station data collected during research cruise KN220-02 using a Vaisala WXT520 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7497977
title: Analyse_Factorielle_Discriminante (AFD) + AFC.xlsx

description: température, pH, DBO , turbidité; salinité moyens avec des taux de d'oxygène, de phosphore, nitrite, nitrate moyennement élevé
DOI: 10.6084/m9.figshare.7497977.v1
title: Analyse_Factorielle_Discriminante (AFD) + AFC.xlsx

description: température, pH, DBO , turbidité; salinité moyens avec des taux de d'oxygène, de phosphore, nitrite, nitrate moyennement élevé
DOI: 10.7284/114495
title: Radiometer data collected during research cruise KN220-02 using a Eppley PIR instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114496
title: Radiometer data collected during research cruise KN220-02 using a Eppley PSP instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.7284/114497
title: Water Temperature data collected during research cruise KN220-02 using a Sea-Bird SBE-48 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7497968.v1
title: ApRES_displacement_14a_Depth.csv

description: ApRES_displacement_14a_Depth.csv: Daily time series of ApRES-measured depth of internal layer reflectors for Deployment 14a (08 May 2014 to 16 July 2014).
DOI: 10.7284/114493
title: TSG (Thermosalinograph) data collected during research cruise KN220-02 using a Sea-Bird SBE-45 instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition
DOI: 10.6084/m9.figshare.7497848
title: Supplementary Material for: Jagged1 is Clinically Prognostic and Promotes Invasion of Glioma-Initiating Cells by Activating NF-κB(p65) Signaling

description: <b><i>Background/Aims:</i></b> Jagged1 is the ligands of the Notch signaling and has been shown to promote glioma-initiating cells (GICs) in glioblastoma. The role of Jagged1 in GICs invasion and underlying molecular mechanisms remain unclear. <b><i>Methods:</i></b> Survival data from R2 genomics analysis, the Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA) and visualization platform database were used to evaluate the effects of Jagged1 on overall patient survival. we investigated Jagged1 induced the GICs cells’ invasion by matrix degradation assays and Transwell cell invasion assays <i>in vitro</i>, then we further explored the underlying molecular mechanisms using Co-immunoprecipitation (co-IP) analysis. <b><i>Results:</i></b> High expression of Jagged1 in human glioma was associated with poor survival. Clinical data analysis showed that the Jagged1 was positively correlated with NF-κB(p65). Jagged1-induced invasion of GICs cells through activation of NF-κB(p65) pathway. <i>In vivo</i>, knockdown of Jagged1 could suppress the tumorigenicity of GICs cells through NF-κB(p65) signaling. <b><i>Conclusion:</i></b> Insights gained from these findings suggest that Jagged1 plays an important oncogenic role in GICs malignancy by activation of NF-κB(p65) signaling, and Jagged1 could be employed as an effective therapeutic target for GICs.
DOI: 10.7284/115089
title: Multiplexed data collected during research cruise KN221-01 using a WHOI Calliope instrument system onboard the platform RV Knorr

description: Original (unprocessed) data collected during a Field_expedition