cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/nnm.24793365
title: B cell-targeted polylactic acid nanoparticles as platform for encapsulating jakinibs: potential therapeutic strategy for systemic lupus erythematosus supplementary materials

description: <b>Background: </b>B cells are pivotal in systemic lupus erythematosus and autoimmune disease pathogenesis. <b>Materials & methods: </b>To address this, Nile Red-labeled polylactic acid nanoparticles (NR-PLA NPs) loaded with the JAK inhibitor baricitinib (BARI), specifically targeting JAK1 and JAK2 in B cells, were developed. <b>Results: </b>Physicochemical characterization confirmed NP stability over 30 days. NR-PLA NPs were selectively bound and internalized by CD19<b>+ </b>B cells, sparing other leukocytes. In contrast to NR-PLA NPs, BARI-NRPLA NPs significantly dampened B-cell activation, proliferation and plasma cell differentiation in healthy controls. They also inhibited key cytokine production. These effects often surpassed those of equimolar free BARI. <b>Conclusion: </b>This study underscores the potential of PLA NPs to regulate autoreactive B cells, offering a novel therapeutic avenue for autoimmune diseases.<b>Plain language summary: </b>In this study, a new approach to treating autoimmune diseases, particularly systemic lupus erythematosus, was investigated by focusing on a type of immune cell called B cells. Special nanoparticles (NPs) labeled with Nile Red (NR) and made from polylactic acid (PLA) were created. These NPs were loaded with a drug called baricitinib (BARI), which targets specific proteins (JAK1 and JAK2) in B cells. This was done to determine if these NPs could help control the behavior of B cells, which are important in autoimmune diseases. First, these NPs remained stable for a long time (30 days). The NRlabeled PLA NPs (NR-PLA NPs) were also good at attaching to and entering a specific type of B cell called CD19<b>+ </b>B cells while leaving other types of immune cells alone. The use of NR-PLA NPs loaded with BARI produced exciting results. These NPs were better at reducing the activity, growth and transformation of B cells into plasma cells compared with the drug BARI by itself. They also stopped the production of certain immune system signals called cytokines, which are usually overactive in autoimmune diseases. This work suggests that PLA NPs could be a promising way to control overactive B cells that contribute to autoimmune diseases like systemic lupus erythematosus. This could open a new and exciting path for developing treatments for these conditions.
DOI: 10.25402/nnm.24793365.v1
title: B cell-targeted polylactic acid nanoparticles as platform for encapsulating jakinibs: potential therapeutic strategy for systemic lupus erythematosus supplementary materials

description: <b>Background: </b>B cells are pivotal in systemic lupus erythematosus and autoimmune disease pathogenesis. <b>Materials & methods: </b>To address this, Nile Red-labeled polylactic acid nanoparticles (NR-PLA NPs) loaded with the JAK inhibitor baricitinib (BARI), specifically targeting JAK1 and JAK2 in B cells, were developed. <b>Results: </b>Physicochemical characterization confirmed NP stability over 30 days. NR-PLA NPs were selectively bound and internalized by CD19<b>+ </b>B cells, sparing other leukocytes. In contrast to NR-PLA NPs, BARI-NRPLA NPs significantly dampened B-cell activation, proliferation and plasma cell differentiation in healthy controls. They also inhibited key cytokine production. These effects often surpassed those of equimolar free BARI. <b>Conclusion: </b>This study underscores the potential of PLA NPs to regulate autoreactive B cells, offering a novel therapeutic avenue for autoimmune diseases.<b>Plain language summary: </b>In this study, a new approach to treating autoimmune diseases, particularly systemic lupus erythematosus, was investigated by focusing on a type of immune cell called B cells. Special nanoparticles (NPs) labeled with Nile Red (NR) and made from polylactic acid (PLA) were created. These NPs were loaded with a drug called baricitinib (BARI), which targets specific proteins (JAK1 and JAK2) in B cells. This was done to determine if these NPs could help control the behavior of B cells, which are important in autoimmune diseases. First, these NPs remained stable for a long time (30 days). The NRlabeled PLA NPs (NR-PLA NPs) were also good at attaching to and entering a specific type of B cell called CD19<b>+ </b>B cells while leaving other types of immune cells alone. The use of NR-PLA NPs loaded with BARI produced exciting results. These NPs were better at reducing the activity, growth and transformation of B cells into plasma cells compared with the drug BARI by itself. They also stopped the production of certain immune system signals called cytokines, which are usually overactive in autoimmune diseases. This work suggests that PLA NPs could be a promising way to control overactive B cells that contribute to autoimmune diseases like systemic lupus erythematosus. This could open a new and exciting path for developing treatments for these conditions.
DOI: 10.25549/examiner-c44-72728
title: Santa Fe train wreck at scene of wreck, 1956

description: 22 images. Santa Fe train wreck at scene of wreck, 23 January 1956. Blood donations given at scene of wreck; Holsey Williams (machinist); general views of train and remains after wreck; Mrs. Peggy Roloff (being prepared for blood transfusion); Ruby Mann (nurse); Sue Mauro (nurse); Patty Jordan (getting blood transfusion); Dick Priddy (custodian carring [sic] blood donated); John McGrath (giving blood). (Sleeve reads: A-11701-019).; Caption slip reads: "Photographer: Mack. Date: 1956-01-23. Reporter: Adler. Assignment: Train wreck -- blood sidebar. 9/10: lineup of men from Battery B, 77th AAA Bn, Fort MacArthur, to give blood at Red Cross HQ -- first in line is Patty Jordan, 18. 3/4: general views of blood donation being given at Red Cross HQ with Mrs. Eva Puckett closest to camera. 1/2: l to r Custodian Dick Friddy carries pints of donated blood to cooler while John McGrath gets fixed up by Nurse Ruby Mann after giving blood. 25/26: two Santa Fe cars in wreck parked in roundhouse, with lead car on left. 33/34: seats taken out of wrecked cars piled up alongside of lead car in roundhouse. 27/28: Machinist Holsey Williams looks at torn rear end of first car in wreck, in roundhouse -- roped off with 'Keep Out' sign. 80/81/51: Mrs. Peggy Roloff being prepared by Nurse Ruby Mann for giving blood at Red Cross. *note [...] making sweater in foreground on table. 50: Nurse Sue Mauro in foreground holding up test tube with blood while others are donating in background. General overall picture of wreck scene -- train was coming into the picture on far left tracks, turned on its side to the right; in far leftbackground [sic] is Olympic boulevard -- on far right is the Los Angeles River. Closeup view of wreck scene. Closeup view of wreck scene with Santa Fe Diesel moving along on same tracks in same direction as wrecked train. Inside shot of car No. 1 showing disrupted seats".
DOI: 10.25402/nnm.24865674
title: Radiofrequency driving antitumor effect of graphene oxide-based nanocomposites: a Hill model analysis - supplementary information

description: <b>Aim: </b>This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. <b>Materials & methods: </b>A nanocomposite was synthesized (graphene oxide–polyethyleneimine–gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. <b>Results: </b>Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. <b>Conclusion: </b>This result points to prospective studies with the tested cell lines using tumor animal models.
DOI: 10.25402/nnm.24865674.v1
title: Radiofrequency driving antitumor effect of graphene oxide-based nanocomposites: a Hill model analysis - supplementary information

description: <b>Aim: </b>This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. <b>Materials & methods: </b>A nanocomposite was synthesized (graphene oxide–polyethyleneimine–gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. <b>Results: </b>Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. <b>Conclusion: </b>This result points to prospective studies with the tested cell lines using tumor animal models.
DOI: 10.25549/examiner-c44-109363
title: Senate Un-American Committee hearing, 1954

description: 9 images. Senate Un-American Committee hearing, 26 July 1954. Albert Lewis -- 65 years (Producer from N.Y.); Jesse Lasky, Junior -- 43 years (Screen writer); Senator Hugh M. Burns (Committee Chairman and "D" Fresno); Howard Estabrook (Screen writer); William Kozlenko -- 47 years (Screen writer and TV writer); Art Arthur (Executive Secretary of Motion Picture Industry Council, Inc.). ; Caption slip reads: "Photographer: Olmo. Reporter: Devlin. Assignment: Senate Un-American Committee. 55: Arthur Lewis, 65, Producer fr. NY. 53: Jesse L. Lasky, Jr., 43, screen writer. 56. Committee Chairman Senator Hugh M. Burns, D-Fresno, Howard Estabrook, screen writer & Academy award winner for 'Cimarron'. 57. Wm. Kozlenko, 47, screen & TV writer. 59. Art Arthur, Executive Secty. of Motion Picture Industry Council, Inc. 23/24, L to R: Sen. Hugh M. Burns, Howard Estabrook."
DOI: 10.15468/dl.a3cps6
title: Occurrence Download

description: A dataset containing 663 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Angelonia angustifolia Benth.)"
 ]
}

 The dataset includes 663 records from 98 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017273-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/examiner-c44-109450
title: French girl hitchhikers, 1954

description: 2 images. French girl hitchhikers, 27 July 1954. Christiane de Beauchaine -- 27 years; Christiane Magontier -- 21 years, of Paris. ; Caption slip reads: "Photographer: Mack. Date: 1954-07-27. Reporter: Massard. Assignment: Grenchgirl hitchhikers. 3/4, left to right: Christiane de Beauchaine, 27, and Christiane Magontier, 21, of Paris."
DOI: 10.25402/nnm.24893613
title: Hyperbranched polyamidoamine–RGD peptide/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis

description: Suppl figures and tables
DOI: 10.25549/examiner-c44-109541
title: Finals (Hair Style Show at Ambassador), 1954

description: 4 images. Finals (Hair Style Show at Ambassador), 11 October 1954. Marlene Kohler -- 20 years; Charles Slough -- 30 years; Barbara Darrow -- 22 years. ; Caption slip reads: "Photographer: Forbes. Date: 10-11. Reporter: Davis. Assignment: Finals -- Hair style show at Ambassador. 21-22-37-38, L to R: Marlene Kohler, 20, of San Diego, who modeled winning hairdo; Charles Slough, 30, of San Diego, winner of grand trophy and creator of best coiffure; and Barbara Darrow, 22, RKO starlet, show's theme girl who presented trophy to Slough."
DOI: 10.25402/nnm.24893613.v1
title: Hyperbranched polyamidoamine–RGD peptide/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis

description: Suppl figures and tables
DOI: 10.25549/examiner-c44-18352
title: Los Angeles City College gymnastics, 1948

description: 10 images. Los Angeles City College gymnastics, 15 December 1948. Richard Beckner; John Beckner; Mark Gilden; Bill Roy.
DOI: 10.25402/nnm.24948639
title: Age-dependent assessment of selenium nanoparticles: biodistribution and toxicity study in young and adult rats supplementary data

description: <b>Aim: </b>To study the biodistribution and toxicology of selenium nanoparticles (SeNPs) versus their bulk counterpart in young and adult male rats in a 28-day study. <b>Methods: </b>SeNPs were synthesized and conjugated with indocyanine green to assess comparative biodistribution by <i>in vivo </i>imaging and further characterized by transmission electron microscopy, Fourier transform infrared, scanning electron microscopy <b>/ </b>energy dispersive x-ray spectroscopy, UV and <b>ζ</b>-analysis. The toxicity of bulk selenium was evaluated relative to its nano form by hematology indices, redox, inflammatory markers and histopathology. <b>Results: </b>Indocyanine green-conjugated nanoparticles showed preferential accumulation in the liver, followed by testis and kidney. The protective effect of SeNPs was more significantly observed in young livers than in adults compared with the bulk counterpart. <b>Conclusion: </b>Age-dependent monitoring and diagnosis of toxicity may need different biomarkers of selenium and may also provide better understanding of SeNPs as therapeutics.<b>Plain language summary: </b>Selenium is an essential element in the body. Its bioactive properties can protect against neurological conditions, diabetes, cancer and other chronic disorders. However, selenium in various biological forms (bulk) can be toxic. Selenium nanoparticles (SeNPs) have unique properties which might prevent this toxicity, providing a potential alternative for selenium supplementation and therapy. However, more studies are needed to see where SeNPs localize in the body, as well as comparing their toxicology with conventional forms of selenium in different age groups. We synthesized and characterized SeNPs of 70–90 nm, then injected them into young and adult rats to see where they distributed in the body. This was compared with rats injected with bulk selenium. SeNPs showed preferential accumulation in the liver, followed by the testes and kidneys. Next, the toxicity profiles of SeNPs and bulk selenium were established by measuring a series of health markers in the liver. It was found that the protection against toxicity provided by SeNPs was more significant in younger rats. Our results demonstrate that the same dose may behave differently in different age groups and that bulk selenium induces different toxicities in young and adult rats compared with SeNPs, highlighting the importance of different indicators of health for the monitoring of selenium-related toxicity when designing selenium-based therapeutics.
DOI: 10.25402/nnm.24948639.v1
title: Age-dependent assessment of selenium nanoparticles: biodistribution and toxicity study in young and adult rats supplementary data

description: <b>Aim: </b>To study the biodistribution and toxicology of selenium nanoparticles (SeNPs) versus their bulk counterpart in young and adult male rats in a 28-day study. <b>Methods: </b>SeNPs were synthesized and conjugated with indocyanine green to assess comparative biodistribution by <i>in vivo </i>imaging and further characterized by transmission electron microscopy, Fourier transform infrared, scanning electron microscopy <b>/ </b>energy dispersive x-ray spectroscopy, UV and <b>ζ</b>-analysis. The toxicity of bulk selenium was evaluated relative to its nano form by hematology indices, redox, inflammatory markers and histopathology. <b>Results: </b>Indocyanine green-conjugated nanoparticles showed preferential accumulation in the liver, followed by testis and kidney. The protective effect of SeNPs was more significantly observed in young livers than in adults compared with the bulk counterpart. <b>Conclusion: </b>Age-dependent monitoring and diagnosis of toxicity may need different biomarkers of selenium and may also provide better understanding of SeNPs as therapeutics.<b>Plain language summary: </b>Selenium is an essential element in the body. Its bioactive properties can protect against neurological conditions, diabetes, cancer and other chronic disorders. However, selenium in various biological forms (bulk) can be toxic. Selenium nanoparticles (SeNPs) have unique properties which might prevent this toxicity, providing a potential alternative for selenium supplementation and therapy. However, more studies are needed to see where SeNPs localize in the body, as well as comparing their toxicology with conventional forms of selenium in different age groups. We synthesized and characterized SeNPs of 70–90 nm, then injected them into young and adult rats to see where they distributed in the body. This was compared with rats injected with bulk selenium. SeNPs showed preferential accumulation in the liver, followed by the testes and kidneys. Next, the toxicity profiles of SeNPs and bulk selenium were established by measuring a series of health markers in the liver. It was found that the protection against toxicity provided by SeNPs was more significant in younger rats. Our results demonstrate that the same dose may behave differently in different age groups and that bulk selenium induces different toxicities in young and adult rats compared with SeNPs, highlighting the importance of different indicators of health for the monitoring of selenium-related toxicity when designing selenium-based therapeutics.
DOI: 10.25549/examiner-c44-16830
title: Kid swimmers, 1951

description: 15 images. Kid swimmers, 22 June 1951. Gwen Pierce, 6; Tina Robbertson, 7; Scott Blow, 7; Tommy Solomon, 6; Donna Fine, 2; Raymond Robinson, 2; Kent and Louise Mans, twins, 3; Tiffany Middleton, 3; Lou Ellen Koehler, 3; Advanced baby class, 2 and 3; Intermediate class, 3, 4 and 5.
DOI: 10.25549/examiner-c44-16752
title: University of Southern California football coach, 1951

description: 3 images. University of Southern California football coach, 31 August 1951. Jess Hill.
DOI: 10.25402/nnm.24973149
title: Phospholipids impact the protective effects of HDL-mimetic nanodiscs against lipopolysaccharide-induced inflammation - supplementary dataset

description: <b>Aim: </b>The impacts of synthetic high-density lipoprotein (sHDL) phospholipid components on anti-sepsis effects were investigated. <b>Methods: </b>sHDL composed with ApoA-I mimetic peptide (22A) and different phosphatidylcholines were prepared and characterized. Anti-inflammatory effects were investigated <i>in vitro </i>and <i>in vivo </i>on lipopolysaccharide (LPS)-induced inflammation models. <b>Results: </b>sHDLs composed with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (22A-DMPC) most effectively neutralizes LPS, inhibits toll-like receptor 4 recruitment into lipid rafts, suppresses nuclear factor <b>κ</b>B signaling and promotes activating transcription factor 3 activating. The lethal endotoxemia animal model showed the protective effects of 22A-DMPC. <b>Conclusion: </b>Phospholipid components affect the stability and fluidity of nanodiscs, impacting the anti-septic efficacy of sHDLs. 22A-DMPC presents the strongest LPS binding and anti-inflammatory effects <i>in vitro </i>and <i>in vivo</i>, suggesting a potential sepsis treatment.<b>Plain language summary: </b>Sepsis is triggered by endotoxins released by bacteria. These endotoxins trigger an exaggerated inflammatory response, leading to widespread inflammation and organ damage. Synthetic high-density lipoprotein (sHDL) is a potential treatment of sepsis by neutralizing endotoxins and regulating inflammatory responses. The phospholipid components of sHDL may affect the effectiveness of sHDL against sepsis. In this study, we prepared sHDLs with different phospholipids and compared their anti-septic effects on cells and in animal models. We found that sHDL made from DMPC presented the best anti-septic effects, possibly because DMPC-sHDL had the best fluidity at body temperature.
DOI: 10.25402/nnm.24973149.v1
title: Phospholipids impact the protective effects of HDL-mimetic nanodiscs against lipopolysaccharide-induced inflammation - supplementary dataset

description: <b>Aim: </b>The impacts of synthetic high-density lipoprotein (sHDL) phospholipid components on anti-sepsis effects were investigated. <b>Methods: </b>sHDL composed with ApoA-I mimetic peptide (22A) and different phosphatidylcholines were prepared and characterized. Anti-inflammatory effects were investigated <i>in vitro </i>and <i>in vivo </i>on lipopolysaccharide (LPS)-induced inflammation models. <b>Results: </b>sHDLs composed with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (22A-DMPC) most effectively neutralizes LPS, inhibits toll-like receptor 4 recruitment into lipid rafts, suppresses nuclear factor <b>κ</b>B signaling and promotes activating transcription factor 3 activating. The lethal endotoxemia animal model showed the protective effects of 22A-DMPC. <b>Conclusion: </b>Phospholipid components affect the stability and fluidity of nanodiscs, impacting the anti-septic efficacy of sHDLs. 22A-DMPC presents the strongest LPS binding and anti-inflammatory effects <i>in vitro </i>and <i>in vivo</i>, suggesting a potential sepsis treatment.<b>Plain language summary: </b>Sepsis is triggered by endotoxins released by bacteria. These endotoxins trigger an exaggerated inflammatory response, leading to widespread inflammation and organ damage. Synthetic high-density lipoprotein (sHDL) is a potential treatment of sepsis by neutralizing endotoxins and regulating inflammatory responses. The phospholipid components of sHDL may affect the effectiveness of sHDL against sepsis. In this study, we prepared sHDLs with different phospholipids and compared their anti-septic effects on cells and in animal models. We found that sHDL made from DMPC presented the best anti-septic effects, possibly because DMPC-sHDL had the best fluidity at body temperature.
DOI: 10.25549/examiner-c44-54718
title: City Council installation, 1953

description: 13 images. City Council installation, 01 July 1953. John S. Gibson, Junior; L.E. Timberlake; John C. Holland; Edward E. Roybal; Harold A. Henry; Everett Burkhalter; Gordon Hahn; Rosalind Weiner; Ernest E. Debs; Harold Harby; Charles Navarro; Arthur Morris; Earle D. Baker; Don A. Allen; Robert M. Wilkinson; Reverend William Meyer; Walter C. Peterson (City Clerk); Roger Arnebergh (City Attorney); Norris Poulson; Dan O. Hoye (controller).; Caption slip reads: "Photographer: Brunk & Rustan. Date: 1953-07-01. Reporter: Reay & Stevens. Assignment: City installation. 4/5/6: Back row - John S. Gibson, Jr.; L.E. Timberlake; John C. Holland; Edward R. Roybal; Harold A. Henry; Everett Burkhalter. Front row - Gordon hahn; Rosalind Weiner; Ernest E. Debs; Harold Harby; Clarles Navarro; Arthur Morris; Earle D. Baker; Don A. Allen; Robert M./ Wilkinson. In far rear: The Rev. William Meyer; Walter C. Peterson, City Clerk.7/8: Roger Arnebergh. 9/10: Harold Henry; Walter C. Peterson, City Clerk. 1: Rosalind Weiner. 2: Edward R. Roybal; Rosalind Weiner. 11/12: Norris Poulson; Harold A. Henry. 13: Norris Poulson".
DOI: 10.15468/dl.f49cbe
title: Occurrence Download

description: A dataset containing 1086 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Echinops polyceras Boiss.)"
 ]
}

 The dataset includes 1086 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0017274-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25549/examiner-c44-9372
title: Disaster drill (Red Cross), 1951

description: 17 images. Disaster drill (Red Cross), May 1, 1951.