cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25442/hku.26143156.v1
title: Supporting data for "Differential effect of saturated and unsaturated fatty acids on γδ-T cell-mediated antitumor immunity"

description: huPBMCs were cultured with BSA, PA, OA, or PA+OA conditions for 14 days. Then BSA-, PA-, OA-, or PA+OA-treated Vγ9Vδ2-T cells were negatively isolated using the TCR γ/δ<sup>+</sup> T cell isolation reagent. Purified Vγ9Vδ2-T cells were co-cultured with target cancer cells for 6 hours. The supernatant was collected for further analyzing the secretions of their effector cytokines and lytic granules. The dead cancer cells were examined by flow cytometry. To explore the effect of PA or OA on the antitumor ability of Vγ9Vδ2-T cells in vivo, human lung cancer A549 cells were injected into Rag2<sup>–/–</sup>γc<sup>–/–</sup> mice conditioning different diets. To examine the changes of glycolysis and OXPHOS of BSA-, PA-, OA-, or PA+OA- Vγ9Vδ2-T cells, Vγ9Vδ2-T cells were isolated and the corresponding ECAR and OCR were detected using seahorse assay. To determine the role of pyroptosis on the impaired antitumor activity induced by PA, after treated Vγ9Vδ2-T cells with BSA, PA, OA, or PA+OA for 12 days, the inhibitor of pyroptosis DMF was used to treat Vγ9Vδ2-T cells overnight. Then the level of LDH release and the expression of pyroptosis markers were determined to verify the inhibitory effect of DMF on pyroptosis. To explore the mechanisms underlying distinct antitumor activity of PA and OA, purified PA or OA treated Vγ9Vδ2-T cells were performed proteomics analysis compared to BSA-treated Vγ9Vδ2-T cells. The Venn program was used to find the distinguished proteins and pathway analysis was used to find the top expressed pathway. After proteomics analysis, the critical pathways or molecules were verified in the BSA, PA, OA, or PA+OA-treated Vγ9Vδ2-T cells. To determine the effect of critical molecule IFNγ on pyroptosis in Vγ9Vδ2-T cells, anti-IFNγ Ab or recombinant IFNγ (rhIFNγ) was used to treat BSA, PA, OA, or PA+OA-treated Vγ9Vδ2-T cells. To determine the role of IFNγ in the antitumor activity of Vγ9Vδ2-T cells, PBMCs were cultured under BSA, PA, OA, or PA+OA conditions for 14 days. Then anti-IFNγ Ab or recombinant IFNγ (rhIFNγ) was used to establish the model of blockade or supplementation of IFNγ. Then the antitumor activity, the secretions of lytic granules, glycolysis, and OXPHOS were detected. We further verified the effect of IFNγ on the antitumor function of Vγ9Vδ2-T cells in vivo. Rag2<sup>–/–</sup>γc<sup>–/–</sup> mice were fed with LFD, palm oil HFD, or olive oil HFD for 30 days. Then GFP<sup>+</sup> A549 tumor cells were subcutaneously inoculated into these mice. On day 7, 12, 17, and 22 following A549 cells inoculation, human anti-IFNγ neutralizing mAb or rhIFNγ was injected into mice intraperitoneally. After 12 hours, the tumor-bearing mice were intravenously injected with BSA-, PA-, or OA-treated Vγ9Vδ2-T cells, respectively. The tumor weight, volume, and survival time were monitored during the experiment.
<br>
DOI: 10.15468/dl.28355m
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is A Bird Atlas of Kenya"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028529-240626123714530/datasets/export for details.
DOI: 10.25442/hku.26117803
title: Supporting data for “NOTHING ENDURES BUT CHANGE: HOW AND WHEN REGULATORY FOCUS CONVERGENCE INFLUENCES TEAM PERFORMANCE"

description: The "Study1_ABM" file contains the agent-based modeling codes for Study 1 in my thesis. Study 1 develops three agent-based models. Specifically, Study 1a is a convergence model that simulates how the interaction among agents influences the convergence of regulatory focus within a team. Study 1b consists of a model for promotion focus convergence and a model for prevention focus convergence. These two models examine the impact of promotion focus convergence and prevention focus convergence on agents. Please open the codes using GAMA Platform (https://gama-platform.org).The "Study2_EmployeeData" file contains employee data collected from an organization.The "Study3_StudentData" file contains student data collected from a university.
DOI: 10.25442/hku.26117803.v1
title: Supporting data for “NOTHING ENDURES BUT CHANGE: HOW AND WHEN REGULATORY FOCUS CONVERGENCE INFLUENCES TEAM PERFORMANCE"

description: The "Study1_ABM" file contains the agent-based modeling codes for Study 1 in my thesis. Study 1 develops three agent-based models. Specifically, Study 1a is a convergence model that simulates how the interaction among agents influences the convergence of regulatory focus within a team. Study 1b consists of a model for promotion focus convergence and a model for prevention focus convergence. These two models examine the impact of promotion focus convergence and prevention focus convergence on agents. Please open the codes using GAMA Platform (https://gama-platform.org).The "Study2_EmployeeData" file contains employee data collected from an organization.The "Study3_StudentData" file contains student data collected from a university.
DOI: 10.15468/dl.z9snyk
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Geometry POLYGON((-96.7666 17.00738,-96.66541 17.00738,-96.66541 17.10968,-96.7666 17.10968,-96.7666 17.00738))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Trochilidae"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028530-240626123714530/datasets/export for details.
DOI: 10.25442/hku.26143924
title: Support data for "Development of a bimetallic zeolite for caries management"

description: Dental caries is a globally prevalent oral disease. It is caused by cariogenic microorganisms, a cariogenic diet, susceptible tooth surfaces and time. Caries begins when cariogenic bacteria accumulate on tooth surfaces and metabolize sugars to produce lactic acid, which leads to tooth demineralization. Demineralization is the process of removing mineral ions (calcium and phosphate) from the hydroxyapatite crystals of the tooth's hard tissue. Therefore, dental materials that inhibit the growth of cariogenic microorganisms and stabilize the release of calcium ions over time are thought to have the potential to control dental caries. In Chapter 2 of my study, I provide a narrative review of the applications of zeolites and zeolite imidazolate frameworks (ZIFs) in various fields of dentistry such as restorative dentistry, endodontics, prosthodontics, implantology, periodontics, orthodontics, and oral surgery. Based on the great potential of zeolites in dentistry, in Chapter 3 of the study, we synthesized a novel zeolite focused on caries management. In Chapter 4 of the study, we developed a novel glass ionomer cement for caries management by adding calcium-silver zeolite to GIC.
DOI: 10.25442/hku.26143924.v1
title: Support data for "Development of a bimetallic zeolite for caries management"

description: Dental caries is a globally prevalent oral disease. It is caused by cariogenic microorganisms, a cariogenic diet, susceptible tooth surfaces and time. Caries begins when cariogenic bacteria accumulate on tooth surfaces and metabolize sugars to produce lactic acid, which leads to tooth demineralization. Demineralization is the process of removing mineral ions (calcium and phosphate) from the hydroxyapatite crystals of the tooth's hard tissue. Therefore, dental materials that inhibit the growth of cariogenic microorganisms and stabilize the release of calcium ions over time are thought to have the potential to control dental caries. In Chapter 2 of my study, I provide a narrative review of the applications of zeolites and zeolite imidazolate frameworks (ZIFs) in various fields of dentistry such as restorative dentistry, endodontics, prosthodontics, implantology, periodontics, orthodontics, and oral surgery. Based on the great potential of zeolites in dentistry, in Chapter 3 of the study, we synthesized a novel zeolite focused on caries management. In Chapter 4 of the study, we developed a novel glass ionomer cement for caries management by adding calcium-silver zeolite to GIC.
DOI: 10.15468/dl.tzyshg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Isopora crateriformis (Gardiner, 1898)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028531-240626123714530/datasets/export for details.
DOI: 10.15468/dl.p3m2fy
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "TaxonKey is Hedwigidium imberbe (Sm.) Bruch & Schimp."
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028532-240626123714530/datasets/export for details.
DOI: 10.25442/hku.26139469
title: Supporting data for "The Role of Planar Cell Polarity in Mammary Gland Development and Tumorigenesis"

description: Planar cell polarity (PCP) is a fundamental mechanism that provides directional information to ensure coordinated cellular behaviors in a group of cells. It plays a vital role in the development and function of a multitude of organs such as brain, inner ear, and skin. We found that the core PCP protein Vangl2 is abundantly expressed in mammary epithelial cells, exhibiting an asymmetric distribution. Our data reveals that the genetic ablation of Vangl2, along with its homologue Vangl1, results in a significant impairment of mammary gland morphogenesis, indicating their critical roles in this biological process. Notably, both Vangl1 and Vangl2 are highly expressed in mammary tumors and have been linked to a negative prognosis in breast cancer patients. Interestingly, we found that genetic ablation of Vangl1 and Vangl2 in cancer cells or in a spontaneous breast cancer PyMT mouse model does not influence the primary tumor growth, but markedly inhibits cancer metastasis. Prior research has shown that metastasis, a lethal factor in breast cancer progression, is strongly associated with the presence of circulating tumor cell (CTC) clusters in the bloodstream. However, the factors modulating the abundance of these CTC clusters remain largely unclear. Our results suggested that Vangl1 and Vangl2 play a significant role in promoting breast cancer metastasis by modulating the formation of CTC clusters within the bloodstream, by regulating the expression of laminin. Collectively, our findings unveil an important function of PCP in both mammary gland development and tumorigenesis.This dataset contains the raw data for the above project.
DOI: 10.25442/hku.26139469.v1
title: Supporting data for "The Role of Planar Cell Polarity in Mammary Gland Development and Tumorigenesis"

description: Planar cell polarity (PCP) is a fundamental mechanism that provides directional information to ensure coordinated cellular behaviors in a group of cells. It plays a vital role in the development and function of a multitude of organs such as brain, inner ear, and skin. We found that the core PCP protein Vangl2 is abundantly expressed in mammary epithelial cells, exhibiting an asymmetric distribution. Our data reveals that the genetic ablation of Vangl2, along with its homologue Vangl1, results in a significant impairment of mammary gland morphogenesis, indicating their critical roles in this biological process. Notably, both Vangl1 and Vangl2 are highly expressed in mammary tumors and have been linked to a negative prognosis in breast cancer patients. Interestingly, we found that genetic ablation of Vangl1 and Vangl2 in cancer cells or in a spontaneous breast cancer PyMT mouse model does not influence the primary tumor growth, but markedly inhibits cancer metastasis. Prior research has shown that metastasis, a lethal factor in breast cancer progression, is strongly associated with the presence of circulating tumor cell (CTC) clusters in the bloodstream. However, the factors modulating the abundance of these CTC clusters remain largely unclear. Our results suggested that Vangl1 and Vangl2 play a significant role in promoting breast cancer metastasis by modulating the formation of CTC clusters within the bloodstream, by regulating the expression of laminin. Collectively, our findings unveil an important function of PCP in both mammary gland development and tumorigenesis.This dataset contains the raw data for the above project.
DOI: 10.25442/hku.26132230
title: Supporting data for "Nidogen-1 modulates type 2 conventional dendritic cell infiltration and builds an immunosuppressive microenvironment in hepatocellular carcinoma"

description: These are supporting data for a Master of Philosophy thesis titled "Nidogen-1 modulates type 2 conventional dendritic cell infiltration and builds an immunosuppressive microenvironment in hepatocellular carcinoma". This repository contains raw data and a processed data file for analysis. This study investigated the role of nidogen-1 in regulating the tumor immune microenvironment in hepatocellular carcinoma. The association between tumor nidogen-1 expression, type 2 conventional dendritic cell infiltration, and tumor development has been unveiled in this study, highlighting the significance of the tolerogenic roles of nidogen-1 and the infiltrated type 2 conventional dendritic cells, which together promote tumor development. The findings of this study are expected to provide insights for further investigations into the specific mechanisms underlying the interaction between nidogen-1 and conventional dendritic cells in hepatocellular carcinoma and ultimately contribute to the development of novel immunotherapeutic approaches.
DOI: 10.25442/hku.26132230.v1
title: Supporting data for "Nidogen-1 modulates type 2 conventional dendritic cell infiltration and builds an immunosuppressive microenvironment in hepatocellular carcinoma"

description: These are supporting data for a Master of Philosophy thesis titled "Nidogen-1 modulates type 2 conventional dendritic cell infiltration and builds an immunosuppressive microenvironment in hepatocellular carcinoma". This repository contains raw data and a processed data file for analysis. This study investigated the role of nidogen-1 in regulating the tumor immune microenvironment in hepatocellular carcinoma. The association between tumor nidogen-1 expression, type 2 conventional dendritic cell infiltration, and tumor development has been unveiled in this study, highlighting the significance of the tolerogenic roles of nidogen-1 and the infiltrated type 2 conventional dendritic cells, which together promote tumor development. The findings of this study are expected to provide insights for further investigations into the specific mechanisms underlying the interaction between nidogen-1 and conventional dendritic cells in hepatocellular carcinoma and ultimately contribute to the development of novel immunotherapeutic approaches.
DOI: 10.25442/hku.26122501
title: Supporting data for "nonalternant nanographenes containing nitrogen-doped nonhexagonal pairs: synthesis, structural analysis and photophysical properties"

description: Under the guidance of Scholl reaction, various nanographenes containg N-doped pentagon-heptagon pairs were synthesized in recent years. Due to the unexpected rearrangements and tedious synthetic routes toward nanographenes containg N-doped pentagon-heptagon pairs during Scholl reaction, the facile methodology is highly desired. Here we reported a series of novel nanographenes bearing N-doped pentagon-heptagon pairs through a facile ring expansion strategy. The resultant physicochemical properties could be fine-tuned through the modifications of heptagon spacers. Furthermore, diverse N-doped nanographenes containing heptagon-octagon pairs obtained from this ring expansion strategy demonstrated the high efficiency of the proposed method.
DOI: 10.25442/hku.26122501.v1
title: Supporting data for "nonalternant nanographenes containing nitrogen-doped nonhexagonal pairs: synthesis, structural analysis and photophysical properties"

description: Under the guidance of Scholl reaction, various nanographenes containg N-doped pentagon-heptagon pairs were synthesized in recent years. Due to the unexpected rearrangements and tedious synthetic routes toward nanographenes containg N-doped pentagon-heptagon pairs during Scholl reaction, the facile methodology is highly desired. Here we reported a series of novel nanographenes bearing N-doped pentagon-heptagon pairs through a facile ring expansion strategy. The resultant physicochemical properties could be fine-tuned through the modifications of heptagon spacers. Furthermore, diverse N-doped nanographenes containing heptagon-octagon pairs obtained from this ring expansion strategy demonstrated the high efficiency of the proposed method.
DOI: 10.25442/hku.25981666
title: <b>Supporting data for "Effects of Bone Marrow-Derived Extracellular Vesicles </b><b>on Fracture Healing"</b>

description: Fracture healing is an orchestrated process involving intricate interactions between periosteal osteoprogenitor cells and bone marrow (BM) immune cells. However, the specific mechanisms through which cells in these distinct niches communicate remain unclear. In our study, we show that long bone fracture leads to the production of a considerable number of pro-regenerative extracellular vesicles (EVs) derived primarily from immune cells in BM. This dataset, compiled from multiple experiments, unveils a previously unknown mechanism for EVs-based direct communication between BM immune cells and periosteal bone-forming cells, which is crucial for fracture healing.
DOI: 10.25442/hku.25981666.v1
title: <b>Supporting data for "Effects of Bone Marrow-Derived Extracellular Vesicles </b><b>on Fracture Healing"</b>

description: Fracture healing is an orchestrated process involving intricate interactions between periosteal osteoprogenitor cells and bone marrow (BM) immune cells. However, the specific mechanisms through which cells in these distinct niches communicate remain unclear. In our study, we show that long bone fracture leads to the production of a considerable number of pro-regenerative extracellular vesicles (EVs) derived primarily from immune cells in BM. This dataset, compiled from multiple experiments, unveils a previously unknown mechanism for EVs-based direct communication between BM immune cells and periosteal bone-forming cells, which is crucial for fracture healing.
DOI: 10.5281/zenodo.12769899
title: MASTERING GRAMMAR WITH NON-NATIVE SPEAKERS: A COMPREHENSIVE GUIDE
DOI: 10.5281/zenodo.12769900
title: MASTERING GRAMMAR WITH NON-NATIVE SPEAKERS: A COMPREHENSIVE GUIDE
DOI: 10.15468/dl.myf5p3
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "TaxonKey is Herbertus acanthelius Spruce"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028535-240626123714530/datasets/export for details.
DOI: 10.15468/dl.tn8thh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Patosia Buchenau"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028536-240626123714530/datasets/export for details.
DOI: 10.15468/dl.dtbq36
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Vulpes vulpes (Linnaeus, 1758)",
 "Year 1970-2024"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028534-240626123714530/datasets/export for details.
DOI: 10.15468/dl.9xwkjf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "TaxonKey is Herbertus bivittatus Spruce"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028537-240626123714530/datasets/export for details.
DOI: 10.34740/kaggle/dsv/8979740
title: Sneaker 899-Classification total-50,000-Images
DOI: 10.15468/dl.ymvrhh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Zameioscirpus Dhooge & Goetgh."
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028538-240626123714530/datasets/export for details.
DOI: 10.15468/dl.h93uc7
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is South America",
 "TaxonKey is Herbertus grossispinus (Steph.) Fulford"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028539-240626123714530/datasets/export for details.
DOI: 10.15468/dl.8rkk5w
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Ecuador",
 "TaxonKey is Sphagneticola trilobata (L.) Pruski"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028540-240626123714530/datasets/export for details.
DOI: 10.15468/dl.n6cbca
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Bursaphelenchus xylophilus Steiner & Buhrer, 1934"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028541-240626123714530/datasets/export for details.
DOI: 10.15468/dl.6gdkbf
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Norwegian breeding bird monitoring scheme"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028533-240626123714530/datasets/export for details.
DOI: 10.5281/zenodo.12769971
title: HEART ARRHYTHMIA DISEASE AND ITS TREATMENT METHODS IN MODERN MEDICINE
DOI: 10.5281/zenodo.12769972
title: HEART ARRHYTHMIA DISEASE AND ITS TREATMENT METHODS IN MODERN MEDICINE
DOI: 10.5281/zenodo.12769254
title: Risk assessment (susceptibility) of thaw slumps and thermokarst lakes in the Yangtze River source region

description: Due to the influence of climate warming, the degradation of permafrost on the Qinghai-Tibet Plateau (QTP) has become evident. The formation of thermokarst hazards induced by the degradation of ice-rich permafrost has a significant impact on infrastructure construction and local ecology; therefore, it is necessary to assess its risk. In this study, a novel multiple thermokarst hazards risk assessment framework was proposed by combining stacking machine learning and potential environmental factors (vegetation factors, terrain factors, climate factors, and soil factors) to assess the risk of thermokarst hazards in the Yangtze River source region (YRSR). The results show the risk assessment (susceptibility) of thermokarst hazards in the YRSR from 2000 to 2016 at 500 m spatial resolution. This study divided the risk into 5 levels: very low (0.0-0.2), low (0.2-0.4), moderate (0.4-0.6), high (0.6-0.8), and very high (0.8-1.0)