cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11416779
title: Supplementary Material for: Clinical Predictors Implicated in the Incidence of Acute Pyelonephritis during the Antepartum Period: A Population-Based Cohort Study

description: <b><i>Introduction:</i></b> Acute pyelonephritis (APN) is a common infection during pregnancy that increases the risk of unfavorable maternal and fetal outcomes. However, it has not been clearly elucidated which demographic and clinical characteristics are associated with the incidence of APN during pregnancy. <b><i>Objective:</i></b> This population-based cohort study aimed to determine the risk factors for APN during pregnancy. <b><i>Methods:</i></b> Using the database of the Health Insurance Review and Assessment Service of South Korea, we enrolled Korean women who delivered infants between 2010 and 2014 in Korea and had complete health examination records within 1 year of pregnancy. We performed multivariate logistic regression analysis to evaluate the risk factors for APN during pregnancy. <b><i>Results:</i></b> Of 370,248 women, 2,526 (0.7% of the total participants) were treated for APN while in hospitalization during pregnancy. Younger age, history of previous APN within 1 year of pregnancy, and abnormal results of health examination before pregnancy, such as high fasting glucose level (&gt;100 mg/dL) and proteinuria, were associated with an increased risk of APN during pregnancy. <b><i>Conclusion:</i></b> Certain maternal demographic and clinical characteristics were associated with the incidence of APN during pregnancy, and these should be monitored closely during antenatal care.
DOI: 10.6084/m9.figshare.11416779.v1
title: Supplementary Material for: Clinical Predictors Implicated in the Incidence of Acute Pyelonephritis during the Antepartum Period: A Population-Based Cohort Study

description: <b><i>Introduction:</i></b> Acute pyelonephritis (APN) is a common infection during pregnancy that increases the risk of unfavorable maternal and fetal outcomes. However, it has not been clearly elucidated which demographic and clinical characteristics are associated with the incidence of APN during pregnancy. <b><i>Objective:</i></b> This population-based cohort study aimed to determine the risk factors for APN during pregnancy. <b><i>Methods:</i></b> Using the database of the Health Insurance Review and Assessment Service of South Korea, we enrolled Korean women who delivered infants between 2010 and 2014 in Korea and had complete health examination records within 1 year of pregnancy. We performed multivariate logistic regression analysis to evaluate the risk factors for APN during pregnancy. <b><i>Results:</i></b> Of 370,248 women, 2,526 (0.7% of the total participants) were treated for APN while in hospitalization during pregnancy. Younger age, history of previous APN within 1 year of pregnancy, and abnormal results of health examination before pregnancy, such as high fasting glucose level (&gt;100 mg/dL) and proteinuria, were associated with an increased risk of APN during pregnancy. <b><i>Conclusion:</i></b> Certain maternal demographic and clinical characteristics were associated with the incidence of APN during pregnancy, and these should be monitored closely during antenatal care.
DOI: 10.6084/m9.figshare.11416776
title: Supplementary Table S1

description: SCFA levels in the different conditions. Treatments were diluted 5 fold in DMEM before adding to the enterohepatic model.
DOI: 10.6084/m9.figshare.11416776.v1
title: Supplementary Table S1

description: SCFA levels in the different conditions. Treatments were diluted 5 fold in DMEM before adding to the enterohepatic model.
DOI: 10.6084/m9.figshare.11416695
title: students dataset for study 'segmentation of experts' knowledge'

description: Data set used in the example 'student data set' (read the .txt file)
DOI: 10.6084/m9.figshare.11416695.v1
title: students data set

description: Data set used in the example 'student data set' (read the .txt file)
DOI: 10.6084/m9.figshare.11416575
title: Supplementary Material for: Germline Missense Mutation of Deleted in Malignant Brain Tumor 1 (<b><i>DMBT1</i></b>) in Familial Mediastinal Neuroendocrine Cancer and in vitro Effects in Thyroid Cancer Cells

description: <b><i>Background:</i></b> Neuroendocrine tumors (NETs) rarely occur in the mediastinum and their etiology and pathogenesis are still unclear. <b><i>Objectives:</i></b> This study assessed inherited or de novo mutations in familial mediastinal NETs. <b><i>Method:</i></b> DNA samples from 4 patients were subjected to the whole-exome sequencing, and Sanger sequencing was used to identify Deleted in malignant brain tumor 1 (<i>DMBT1</i>) mutations in all 45 family members. <b><i>Results:</i></b> All patients showed a germline <i>DMBT1</i> mutation at 4971C. Sanger sequencing data showed that 4 NETs and 2 carriers in the first patient’s family and 2 NETs and 4 carriers in the second patient’s family, respectively, had this<i> DMBT1</i> mutation. The in vitro data showed that the ectopic expression of DMBT1 reduced tumor cell viability and migration by arresting the G1/S phase of the cell cycle. <b><i>Conclusions:</i></b> We identified a germline missense mutation in DMBT1<sup>D1657E</sup> as a susceptibility gene for familial mediastinal NETs.
DOI: 10.6084/m9.figshare.11416575.v1
title: Supplementary Material for: Germline Missense Mutation of Deleted in Malignant Brain Tumor 1 (<b><i>DMBT1</i></b>) in Familial Mediastinal Neuroendocrine Cancer and in vitro Effects in Thyroid Cancer Cells

description: <b><i>Background:</i></b> Neuroendocrine tumors (NETs) rarely occur in the mediastinum and their etiology and pathogenesis are still unclear. <b><i>Objectives:</i></b> This study assessed inherited or de novo mutations in familial mediastinal NETs. <b><i>Method:</i></b> DNA samples from 4 patients were subjected to the whole-exome sequencing, and Sanger sequencing was used to identify Deleted in malignant brain tumor 1 (<i>DMBT1</i>) mutations in all 45 family members. <b><i>Results:</i></b> All patients showed a germline <i>DMBT1</i> mutation at 4971C. Sanger sequencing data showed that 4 NETs and 2 carriers in the first patient’s family and 2 NETs and 4 carriers in the second patient’s family, respectively, had this<i> DMBT1</i> mutation. The in vitro data showed that the ectopic expression of DMBT1 reduced tumor cell viability and migration by arresting the G1/S phase of the cell cycle. <b><i>Conclusions:</i></b> We identified a germline missense mutation in DMBT1<sup>D1657E</sup> as a susceptibility gene for familial mediastinal NETs.
DOI: 10.6084/m9.figshare.11416395
title: The RNA binding protein Quaking represses host interferon response by downregulating MAVS

description: Quaking (QKI) is an RNA-binding protein (RBP) involved in multiple aspects of RNA metabolism and many biological processes. Despite a known immune function in regulating monocyte differentiation and inflammatory responses, the degree to which QKI regulates the host interferon (IFN) response remains poorly characterized. Here we show that QKI ablation enhances poly(I:C) and viral infection-induced IFNΒ transcription. Characterization of IFN-related signaling cascades reveals that QKI knockout results in higher levels of IRF3 phosphorylation. Interestingly, complementation with QKI-5 isoform alone is sufficient to rescue this phenotype and reduces IRF3 phosphorylation. Further analysis shows that MAVS, but not RIG-I or MDA5, is robustly upregulated in the absence of QKI, suggesting that QKI downregulates MAVS and thus represses the host IFN response. As expected, MAVS depletion reduces IFNΒ activation and knockout of MAVS in the QKI knockout cells completely abolishes IFNΒ induction. Consistently, ectopic expression of RIG-I activates stronger IFNΒ induction via MAVS-IRF3 pathway in the absence of QKI. Collectively, these findings demonstrate a novel role for QKI in negatively regulating host IFN response by reducing MAVS levels.
DOI: 10.6084/m9.figshare.11416392
title: Supplementary Material for: Accelerated Dose Escalation with Three Injections of an Aluminum Hydroxide-Adsorbed Allergoid Preparation of Six Grasses Is Safe for Patients with Moderate to Severe Allergic Rhinitis

description: Only few data on safety during high-dose, accelerated escalation schedules during subcutaneous allergen immunotherapy (AIT) are available. The aim of this study was to assess the safety and tolerability of an accelerated dose escalation schedule of AIT in adult patients with moderate to severe seasonal rhinoconjunctivitis in a multicenter, open-label, randomized phase II trial. The dose escalation scheme for patients in Group I (1 strength) included 3 injections with 1 strength, B (10,000 TU/mL), whereas the dose escalation scheme for Group II (standard) included 7 injections with 2 strengths, A (1,000 TU/mL) and B (10,000 TU/mL), of an aluminum hydroxide-adsorbed allergoid grass pollen preparation. Overall, 72 of 87 randomized patients (83.7%) reported at least 1 treatment-emergent adverse event (TEAE; 82.2 [Group I] vs. 85.4% [Group II]); 58.8% of all reported TEAEs were assessed as being related to AIT (60.0 vs. 48.8%). The most frequently reported AIT-related TEAEs were swelling (46.7 vs. 34.1%), erythema (28.9 vs. 36.6%), and pruritus (31.1 vs. 17.1%) at the site of the injection. Systemic allergic reactions occurred in 5 (5.8%) patients overall, with more being reported in the 1-strength group (4 [8.9%] vs. 1 [2.4%]). All systemic allergic reactions were classified as World Allergy Organization (WAO) Grade 1 or Grade 2 reactions. Accelerated high-dose escalation with an aluminum hydroxide-adsorbed grass pollen allergoid can be initiated with a safety and tolerability profile comparable to the standard dose escalation schedule in patients with allergic rhinitis with or without asthma.
DOI: 10.6084/m9.figshare.11416395.v1
title: The RNA binding protein Quaking represses host interferon response by downregulating MAVS

description: Quaking (QKI) is an RNA-binding protein (RBP) involved in multiple aspects of RNA metabolism and many biological processes. Despite a known immune function in regulating monocyte differentiation and inflammatory responses, the degree to which QKI regulates the host interferon (IFN) response remains poorly characterized. Here we show that QKI ablation enhances poly(I:C) and viral infection-induced IFNΒ transcription. Characterization of IFN-related signaling cascades reveals that QKI knockout results in higher levels of IRF3 phosphorylation. Interestingly, complementation with QKI-5 isoform alone is sufficient to rescue this phenotype and reduces IRF3 phosphorylation. Further analysis shows that MAVS, but not RIG-I or MDA5, is robustly upregulated in the absence of QKI, suggesting that QKI downregulates MAVS and thus represses the host IFN response. As expected, MAVS depletion reduces IFNΒ activation and knockout of MAVS in the QKI knockout cells completely abolishes IFNΒ induction. Consistently, ectopic expression of RIG-I activates stronger IFNΒ induction via MAVS-IRF3 pathway in the absence of QKI. Collectively, these findings demonstrate a novel role for QKI in negatively regulating host IFN response by reducing MAVS levels.
DOI: 10.6084/m9.figshare.11416317
title: Data for Lakshmi et al. (2020) “ Entrainment driven summer monsoon chlorophyll bloom off Somalia coast ".

description: MOM5.1 – TOPAZ model output for Lakshmi et al. (2020), “ Entrainment driven summer monsoon chlorophyll bloom off Somalia coast”. Monthly climatological data prepared from 17 years of interannual simulations used for the analysis are available. The data sets are seggregated as three different netcdf files , one consisting all the variables for Somali box, other for whole Arabian Sea and the third file consists all the surface variables used in this study. Also uploaded a text file which include the information of the transect used for the study. The details of the data are provided in a README file.
DOI: 10.6084/m9.figshare.11416317.v1
title: Data for Lakshmi et al. (2020) “ Entrainment driven summer monsoon chlorophyll bloom off Somalia coast ".

description: MOM5.1 – TOPAZ model output for Lakshmi et al. (2020), “ Entrainment driven summer monsoon chlorophyll bloom off Somalia coast”. Monthly climatological data prepared from 17 years of interannual simulations used for the analysis are available. The data sets are seggregated as three different netcdf files , one consisting all the variables for Somali box, other for whole Arabian Sea and the third file consists all the surface variables used in this study. Also uploaded a text file which include the information of the transect used for the study. The details of the data are provided in a README file.
DOI: 10.6084/m9.figshare.11416227
title: MOESM1 of DUF3669, a “domain of unknown function” within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression

description: Additional file 1. Compilation of DUF3669-KRAB-ZNF proteins from amniotes. Individual sheets for the ortholog groups based on the human members, an “unassigned” group and a table with a group count.
DOI: 10.6084/m9.figshare.11416227.v1
title: MOESM1 of DUF3669, a “domain of unknown function” within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression

description: Additional file 1. Compilation of DUF3669-KRAB-ZNF proteins from amniotes. Individual sheets for the ortholog groups based on the human members, an “unassigned” group and a table with a group count.
DOI: 10.6084/m9.figshare.11416206
title: MOESM3 of Direct comparison of Arabidopsis gene expression reveals different responses to melatonin versus auxin

description: Additional file 3: Table S5: GO functional annotation and additional details of genes regulated by melatonin (100 Î¼M) as comapred to the solvent control (0.1% v/v ethanol).
DOI: 10.6084/m9.figshare.11416206.v1
title: MOESM3 of Direct comparison of Arabidopsis gene expression reveals different responses to melatonin versus auxin

description: Additional file 3: Table S5: GO functional annotation and additional details of genes regulated by melatonin (100 Î¼M) as comapred to the solvent control (0.1% v/v ethanol).
DOI: 10.6084/m9.figshare.11416197
title: MOESM2 of Direct comparison of Arabidopsis gene expression reveals different responses to melatonin versus auxin

description: Additional file 2: Table S4. DEGs regulated by NAA as compared to the solvent control (0.1% v/v ethanol).
DOI: 10.6084/m9.figshare.11416197.v1
title: MOESM2 of Direct comparison of Arabidopsis gene expression reveals different responses to melatonin versus auxin

description: Additional file 2: Table S4. DEGs regulated by NAA as compared to the solvent control (0.1% v/v ethanol).
DOI: 10.6084/m9.figshare.11416128
title: MOESM7 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

description: Additional file 7. Microarray data.
DOI: 10.6084/m9.figshare.11416128.v1
title: MOESM7 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

description: Additional file 7. Microarray data.
DOI: 10.6084/m9.figshare.11416101
title: MOESM3 of Validation of an equine serum amyloid A assay with an unusually broad working range

description: Additional file 3. Overview of healthy horses used for calculating reference interval.
DOI: 10.6084/m9.figshare.11416101.v1
title: MOESM3 of Validation of an equine serum amyloid A assay with an unusually broad working range

description: Additional file 3. Overview of healthy horses used for calculating reference interval.
DOI: 10.6084/m9.figshare.11416098
title: MOESM2 of Validation of an equine serum amyloid A assay with an unusually broad working range

description: Additional file 2. Overview of diagnoses/reason for hospitalization in the three groups of horses used to assess overlap performance.
DOI: 10.6084/m9.figshare.11416098.v1
title: MOESM2 of Validation of an equine serum amyloid A assay with an unusually broad working range

description: Additional file 2. Overview of diagnoses/reason for hospitalization in the three groups of horses used to assess overlap performance.
DOI: 10.6084/m9.figshare.11416083
title: MOESM8 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 8: Table S7. DP clusters.
DOI: 10.6084/m9.figshare.11416083.v1
title: MOESM8 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 8: Table S7. DP clusters.
DOI: 10.6084/m9.figshare.11416074
title: MOESM7 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 7: Table S6. DE clusters.
DOI: 10.6084/m9.figshare.11416074.v1
title: MOESM7 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 7: Table S6. DE clusters.
DOI: 10.6084/m9.figshare.12865547
title: Extreme and variable environmental temperatures are linked to reduction of social network cohesiveness in a highly social passerine - DATA

description: Panting and association data (Obs-Focal)Social network data (Networkbasedmetrics)Climate data (IBobs_with session...)
DOI: 10.6084/m9.figshare.12865547.v1
title: Extreme and variable environmental temperatures are linked to reduction of social network cohesiveness in a highly social passerine - DATA

description: Panting and association data (Obs-Focal)Social network data (Networkbasedmetrics)Climate data (IBobs_with session...)
DOI: 10.6084/m9.figshare.11416062
title: MOESM6 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 6: Table S5. DEG clusters.
DOI: 10.6084/m9.figshare.11416062.v1
title: MOESM6 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 6: Table S5. DEG clusters.
DOI: 10.6084/m9.figshare.11416053
title: MOESM5 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 5: Table S4. GWAS and enhancer sites.
DOI: 10.6084/m9.figshare.11416053.v1
title: MOESM5 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 5: Table S4. GWAS and enhancer sites.
DOI: 10.6084/m9.figshare.11416044
title: MOESM5 of Genome-wide analysis and characterization of F-box gene family in Gossypium hirsutum L

description: Additional file 5: Table S1. Detailed information of FBOX members from Upland cotton. Table S2. Detailed information of F-box members from G. raimondii. Table S3. Detailed information of F-box members from G.arboreum. Table S4. Upland cotton F-box gene numbers for different modes of gene duplication. Table S5. Organ-specific expression patterns of F-box genes. Table S6. Optimal numbers of clusters (K) as determined by ‘k-means’ clustering. Table S7. F-box gene as the SCF complexes involved in hormone signal transduction based on the homologous gene in Arabidopsis. Table S8. real-time PCR primers.
DOI: 10.6084/m9.figshare.11416044.v1
title: MOESM5 of Genome-wide analysis and characterization of F-box gene family in Gossypium hirsutum L

description: Additional file 5: Table S1. Detailed information of FBOX members from Upland cotton. Table S2. Detailed information of F-box members from G. raimondii. Table S3. Detailed information of F-box members from G.arboreum. Table S4. Upland cotton F-box gene numbers for different modes of gene duplication. Table S5. Organ-specific expression patterns of F-box genes. Table S6. Optimal numbers of clusters (K) as determined by ‘k-means’ clustering. Table S7. F-box gene as the SCF complexes involved in hormone signal transduction based on the homologous gene in Arabidopsis. Table S8. real-time PCR primers.
DOI: 10.6084/m9.figshare.11416041
title: MOESM4 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 4: Table S3. EC enhancer sites.
DOI: 10.6084/m9.figshare.11416041.v1
title: MOESM4 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 4: Table S3. EC enhancer sites.
DOI: 10.6084/m9.figshare.11416023
title: MOESM4 of A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays

description: Additional file 4. Excel spreadsheet of raw fluorescence data, plus graphs; and fluorescence-to-molarity calibration curves using different concentrations of oxidised probes.
DOI: 10.6084/m9.figshare.11416020
title: MOESM2 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 2: Table S2. Quality values of ChIP-seq and RNA-seq data.
DOI: 10.6084/m9.figshare.11416023.v1
title: MOESM4 of A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays

description: Additional file 4. Excel spreadsheet of raw fluorescence data, plus graphs; and fluorescence-to-molarity calibration curves using different concentrations of oxidised probes.
DOI: 10.6084/m9.figshare.11416020.v1
title: MOESM2 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 2: Table S2. Quality values of ChIP-seq and RNA-seq data.
DOI: 10.6084/m9.figshare.11416011
title: MOESM1 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 1: Table S1. EC sample list.
DOI: 10.6084/m9.figshare.11416011.v1
title: MOESM1 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

description: Additional file 1: Table S1. EC sample list.
DOI: 10.6084/m9.figshare.11415903
title: MOESM2 of Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway

description: Additional file 2: Table S3. Raw data of [Ca2+]i (Fura-FF f340/f380 fluorescence) measurements.
DOI: 10.6084/m9.figshare.11415903.v1
title: MOESM2 of Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway

description: Additional file 2: Table S3. Raw data of [Ca2+]i (Fura-FF f340/f380 fluorescence) measurements.
DOI: 10.6084/m9.figshare.11415885
title: MOESM9 of Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer

description: Additional file 9: Logistic regression analysis between stratified clinical, response and treatment parameters and normalized continuous biomarkers, showing the p-value, Odd ratio and the 95% confidence interval for this Odd ratio. Univariate and multivariate analysis. Table containing information regarding the interactions between biomarkers, as continuous variables, and different clinical parameters and treatment received by the patient.
DOI: 10.6084/m9.figshare.11415885.v1
title: MOESM9 of Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer

description: Additional file 9: Logistic regression analysis between stratified clinical, response and treatment parameters and normalized continuous biomarkers, showing the p-value, Odd ratio and the 95% confidence interval for this Odd ratio. Univariate and multivariate analysis. Table containing information regarding the interactions between biomarkers, as continuous variables, and different clinical parameters and treatment received by the patient.