cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.14457/cu.the.2009.1657
title: Regulation of IL-6 expression by notch signaling in murine macrophages

description: Notch receptors and ligands are families of proteins involved in signal transduction of Notch signaling pathway. Interaction between Notch ligands and their receptors triggers cleavage of Notch receptor by gamma secretase which leads to signal transduction. Notch signaling plays important roles in development of metazoan cells, including immune cells. For signaling transduction, Notch receptors bind to CSL, a DNA- protein, in the nucleus and induce expression of target genes. In macrophages which are innate immune cells, Notch signaling regulates antigen presentation capacity and inflammatory responses such as secretion of pro-inflammatory cytokines including IL-6. IL-6 is a multifunctional cytokine secreted by various cell types, including macrophages. IL-6 functions in immune regulation and inflammation. Previous studies and our preliminary search identified the consensus CSL binding site in the promoter region of IL-6 and CSL was shown to negatively regulate IL-6 expression, but the role of Notch signaling in IL-6 expression in macrophages remained unresolved. Therefore, this study aimed at investigating the role of Notch signaling in regulation of IL-6 expression in murine macrophages. Our results showed that activated macrophages with LPS and interferon gamma induced IL-6 expression in correlation with the upregulation of Notch1 expression. Inhibition of the Notch signaling in macrophages using IL-CHO, a gamma secretase inhibitor, significantly decreased IL-6 expression. Macrophages transiently transfected with truncated constitutively active Notch1 resulted in dramatic increase in both IL-6 mRNA and secreted IL-6. When chromatin immunoprecipitation assay was used to prove whether Notch1 binds to the promoter of IL-6, only RNA polymerase II was found to bind to such promoter. The result for Notch1 binding was inconclusive because of the non-specific binding. Taken together, the results obtained in this study demonstrated that Notch signaling pathway plays an important role in IL-6 expression in macrophages. This finding may lead to a drug design targeting diseases with aberrant IL-6 secretion through Notch signaling.
DOI: 10.14457/cu.the.2009.1658
title: Process improvement for it data centre migration by it infrastructure library (ITIL) guideline

description: This thesis studies the process improvement for IT data centre migration by IT infrastructure (ITIL) guideline. The objective of this study is to create process guideline for improving IT data centre migration – new data centre allocation by using ITIL guideline. The Information Technology Infrastructure Library (ITIL) is a framework of best practices, which forms the basis of the British Standard for IT Service Management. It has been selected as it is rapidly becoming the internationally accepted standard, and provides a clear set of processes into which the IT Department and the prevailing internal service culture will integrate. The proposed thesis for implementation of this framework will prioritize and progressively address the outstanding issues experienced with inconsistent levels of service provided by IT and will enable the IT Department to provide a higher quality customer service given the current budgetary constrains. The primary and important objective of this work is trying to find and analyze common and typical incidents and problems of IT service especially in data centre application management field. Find and create process to be improved the service management. It is coming from the Service management perspective and approach. All major topics are covered within Service Management mindset. The problems will be examined and analyzed by application management part of ITIL. The conclusion of this study is to create a guideline for IT data centre migration.
DOI: 10.14457/cu.the.2009.1659
title: Formulation and Evaluation of O/W emultions containingsd Arabinoxylans from rice barn residues

description: In this study arabinoxylans was extracted from rice bran by warm water. The chemical structures were characterized by Fourier Transform-Infrared Resonance (FT-IR) and Nuclear Magnetic Resonance (NMR) Spectroscopy. The o/w emulsions containing arabinoxylans were formulated by varying the ratios of emulsifying agent, Brij 72 to Brij 721 of 1:4, 2:3, 1:1, 3:2 and 4:1. The in vivo efficacies were evaluated in 30 healthy female volunteers whose age in range 30-55 years using single blind trials for moisturizer, elasticity and wrinkle determination. The yield of extracted arabinoxylans was 0.29 %w/w. The selected o/w emulsions containing arabinoxylans consisted of 1% w/w of arabinoxylans and the ratio of Brij 72 to Brij 721 was 3:2, which gave the most satisfactory with physical appearances and the skin feeling and spread ability. Moreover, the o/w emulsions containing arabinoxylans was stable and passed 6 heating-cooling cycles. In vivo efficacies of o/w emulsion containing arabinoxylans were evaluated for moisture content and elasticity using Skin Diagnostic SD 27 and DermaLab® Elasticity probe instrument, respectively. These efficacy evaluations on the face (cheek and forehead) were investigated for 8 weeks. They show that the product increased the moisturizing property, reduced young’s modulus which resulted in increasing skin elasticity with significant difference in 1-8 weeks. The results were also observed by macroscopic photographs that show the reduction of wrinkle line on forehead. It is suggested that arabinoxylans extract may be a candidate for an efficient moisturizing agent.
DOI: 10.14457/cu.the.2009.1660
title: Factors affecting soft tissue recession around anterior maxillary single-tooth implants

description: Background: Peri-implant soft tissue recession is a major esthetic concern for the anterior implants. The aim of this study was to determine factors that affected the facial marginal recession and papillary recession around single-tooth implants in the anterior maxilla. Methods: Forty single-tooth implants in the anterior maxilla were studied. Variables possibly associated with soft tissue recession were obtained from clinical measurements, study models, peri-apical radiographs, and computerized tomograms. The Fisher’s exact test, analysis of variance, and binary logistic regression analysis were used to determine the influence of each factor on facial marginal recession and papillary recession. Results: The majority of the implants (75%) replaced the upper central incisors. The mean facial marginal recession was 0.5 ± 0.9 mm. Eighty-nine percents of the implants had more than half of papilla fill. Facial marginal recession was influenced by many factors. Increased risk of facial marginal recession was significantly associated with thin peri-implant biotype, proclined implant fixture angle, more apical level of facial bone crest, increased distance from contact point to bone crest, contact point to platform, and contact point to implant bone. Thin biotype was the most significant factor in determining the presence of facial marginal recession. Increased distance from contact point to bone crest was the only factor significantly associated with increased risk for papillary recession. Conclusions: Papillary recession around single-tooth implants in the anterior maxilla was mainly influenced by the interproximal bone crest level of the adjacent tooth. Facial marginal recession, on the other hand, was affected by multiple factors including, the peri-implant biotype, the facial bone crest level, the implant fixture angle, the interproximal bone crest level, the depth of implant platform, and the level of first bone to implant contact.
DOI: 10.14457/cu.the.2009.1661
title: The ideology of love in popular Thai tragic romance, 1997-2007

description: This research aims at sutdying the ideology of love in popular Thai tragic romance during 1997-2007 in order to see the persistence and change of ideology of love in Thai society, as a result of the interaction between ideology of love in Buddhism and Consumerism in Thai society. The research is qualitative research. The major data are ten tragic romance in a form of films; The Legend of Warlord, Nang Nak, Behind the Painting, Maebia, The Whistle, The Letter Monrak Transistor, Dear Dakanda, Me Myself, and Love of Siam, but other types of popular narrative, such as television series and popular songs during 1997-2007 will be included, to support the major data and major argument in this research. The research is divided into two parts. The firs part explains the relation between tragic romance and ideology of love. Tragic romance has a role in giving its audience an ethical education. The audience will learn the ideology of love through and from experiencing tragic romance in the film. The second part shows the interaction between ideology of love in Buddhism and Consumerism. There are two ideologies of romantic love in Buddhism; love is suffering and love is a consequence of previous association, Pubbhesannivasa. For Consumerism, there are two main ideologies of romantic love; love is a goal of life and 'a must' for life, which can be concluded as love is the most important thing in life. From the data, popular Thai tragic romance persuades its audience to believe in love, to love, and focus on love as a 'need' for life. Although, love will cause suffering at the end, but this suffering is appreciable as long as the audience realize that they do love or are loved. Suffering from love is not presented as a suffering (dhukka) in life, but it is happiness. Hence, popular Thai tragic romance encourages its rudience to cling to the person they love and to use their love as a motivation to continue their life. Moreover, Love becomes another kind of commodity for consumption. Furthermore, the research also found that the idea of previous association in Thai Buddhism has been questioned and rarely presented in tragic romance. The idea of destiny (Brahmalikit) is more popular and is mentioned more often than previous association, but it is also questioned and doubted by average Thai Buddhists. Contemporary Thai tragic romance propagates the individualism or free will in love over the idea of predestined. Love is not a will from the past or the will of the divine, but it is a free will to love or not to love someone. However, the research also found that there is an emergence of the concept of compassionate love influenced by Buddhism (metta and karuna) in the data. Living together with goodwill is more important than being attached to one another. This shows that the ideology of love in Buddhism still persists and has a significant role in Thai society
DOI: 10.14457/cu.the.2009.1662
title: Micro/nanospheres from polysilsesquioxane containing uva-absorbing group

description: In this research, we prepared polysilsesquioxane micro/nanospheres with UV absorption property through the polymerization process of hybrid monomer, triethoxysilylpropyl-4-methoxycinnamamide and triethoxysilylpropyl-2,4-dimethoxycinnamamide. It was found that the catalysis types and volume of solvent used during the particle formation, affected particle size and product yield. Particle size increased with the increased volume of solvent but the high volume of solvent inversely correlated with product yield. Moreover, polymerization at higher monomer concentration gave a lower yield. Encapsulation of 2-ethylhexyl-4-methoxycinnamate into poly[propyl-4-methoxycinnamamide silsesquioxane], PTES4C and poly[propyl-2,4-dimethoxycinnamamide silsesquioxane], PTES24C spherical particles could be carried out successfully at 61.54% encapsulation efficiency (20.86% loading) and 31.87% encapsulation efficiency (10.17% loading), respectively.
DOI: 10.14457/cu.the.2009.1663
title: Pretreatment of sugarcane leaves to enhance cellulase hydrolysis for ehanol fermentation by Saccharomyces cerevisiae

description: Sugarcane leaves pretreated by dilute sulfuric acid was more susceptible to cellulase than those pretreated by lime. Optimal condition for the dilute sulfuric acid pretreatment was 6% (w/v) substrate (20-40 mesh particle size) loading, 1.5% (w/v) H2SO4 at 121oC, 15 lb/in2, 30 min. Hydrolysis of the dilute sulfuric acid pretreated sugarcane leaves slurry by cellulase (10 FPU/g, dry weigh basis (DS): β-glucosidase 3.55 salicin Unit/ml) for 6h yield 0.057 glucose g/g DS. Hydrolysis of the dilute sulfuric acid pretreated sugarcane leaves by AcellulaseTM1000 at 160 FPU/g (DS) (β-glucosidase 400 pNPGU/g) for 6 h resulted in glucose 9.8 g/l. The glucose was further fermented to ethanol by Saccharomyces cerevisiae TISTR 5596 for 24 h. Ethanol yield was 4.71 g/l (0.48 g/g glucose) or 0.20 g/g cellulose (0.08 g ethanol/g (DS) sugarcane leaves). Pretreatment of sugarcane leaves by dilute sulfuric acid released xylose 0.11 g/g (DS) which was the same as glucose released after cellulase hydrolysis (0.12 g/g (DS)). So, both of xylose and glucose were fermented to ethanol by Pichia stipitis and S.cerevisiae TISTR 5596, respectively. Flask scale fermentation gave ethanol from xylose (3.12 g/l or 0.35 g/g xylose) at 96h, and from glucose (2.9 g/l or 0.46 g/g glucose) at 12h. Total ethanol yield in flask scale was 6.02 g or 0.10 g ethanol/g (DS) sugarcane leaves. Three liters scale fermentation in 5L fermenter gave ethanol from xylose (4.08 g/l or 0.47 g/g xylose) at 96h, and from glucose (3.05 g/l or 0.49 g/g glucose) at 12h. Total ethanol yield in 3L fermenter scale was 7.13 g or 0.12 g ethanol/ g (DS) sugarcane leaves.
DOI: 10.14457/cu.the.2009.1664
title: Bioactive compounds from marine fungi strains Nodulisprium sp., Aspergillus sp.and Penicillium citrinum

description: Bioactive compounds of the marine-derived fungi Nodulisporium sp., Aspergillus unguis and Penicillium citrinum were explored. The spong-derived fungus Nodulisporium sp. produced know natural products 1, 2 and 3, while Aspergillus unguis produced compound 4, niludin (5) and 6. Furthermore, O-methyl derivatives 7 and 8 were prepared. The marine-derived fungus, Penicillium citrinum produced 9, pinselin (10) and compound 11. All structures were elucidated by extensive spectroscopic analysis. In this study, some compounds exhibited cytotoxic activity against HuCCA-1, A549, HepG-2 and MOLT-3 cancer cell lines.
DOI: 10.14457/cu.the.2009.1665
title: Formulation of Silymarin Microemulsion for dermal delivery

description: Silymarin is a standardized extract from the seeds of Silybum marianum. Due to its antioxidant, anti-inflammatory, and immunomodulatory properties, silymarin may prevent UV-induced skin disorders including erythema, edema, sun burn cell formation, photoaging, and skin cancer. The objective of this study is to prepare silymarin-loaded microemulsions for dermal delivery and then evaluate its release properties, stabilities and permeability. Glyceryl monooleate, oleic acid, ethyl oleate, isopropyl myristate were selected as an oil phase, mixture of Tween 20® and HCO-40® (1:1), Labrasol® and HCO-40® (1:1) or Span 20® and HCO-40® (1:1) were selected as surfactants, and Transcutol® was used as a cosurfactant to construct the pseudo-ternary phase diagrams. From each pseudo-ternary phase diagram, o/w microemulsion with low surfactants/cosurfactant mixture (Smix) content was selected for dermal delivery of silymarin and to avoid skin irritation from surfactant and oil. Microemulsions containing 2% w/w silymarin showed a good physical stability; remained transparent and no phase separation or drug precipitation after 6 heating-cooling cycles. However, silybin, the main active component of silymarin, degraded during storage of microemulsions at 40C for 6 months. The percentages of silybin remainings were sequenced in the order of surfactants: Labrasol® &gt; Tween 20® &gt; Span 20® (as HCO-40® was used in every formulation). In vitro releases of silymarin microemulsions showed the prolong release when compared to its solution (40% ethanol in phosphate buffer saline pH 7.4). All silymarin release profiles showed the best fit with Higuchi kinetics and the release rate constants of silymarin from microemulsions were not significantly different. In vitro skin permeation study found that silybin could not be detected in the concentrated receiver fluid. The percentages of silybin remainings in skin extracts from silymarin microemulsions were not significantly different, except for the solution which significantly higher than microemulsions. However, alcohol solutions are still not suitable for skin delivery due to their skin irritation. For further studies, the permeation study in occlusive condition should be performed comparing to this non-occlusive condition, as well as in vivo studies of efficacy and skin irritation of silymarin microemulsions.
DOI: 10.14457/cu.the.2009.1666
title: Effects of gelatin conjugation and hydroxyapatite deposition on Thai silk fibroin scaffolds

description: This research aimed to investigate the effects of gelatin conjugation and hydroxyapatite deposition on the physical and biological properties of Thai silk fibroin scaffolds for bone tissue engineering. Thai silk fibroin scaffolds were prepared via salt-leaching method. The morphology of scaffolds showed smooth surface and interconnected porous network. Surface of silk fibroin scaffolds were modified by gelatin conjugation and hydroxyapatite deposition by alternate soaking in calcium chloride and disodium hydrogenphosphate solutions. The different concentration of gelatin solution was found to influence the amount of gelatin conjugated onto Thai silk fibroin scaffolds, the morphology of the scaffolds and the cell proliferation on the scaffolds. After alternate soaking, hydroxyapatite was observed on the pore surface of scaffolds leading to the rough surface of porous structure and less pore volume. The scaffolds obtained from 4 cycles of alternate soaking in calcium chloride and disodium hydrogenphosphate solutions alternately with the soaking time for 30 minutes in each solution showed suitably porous morphology and compressive modulus. The results on TGA indicated that hydroxyapatite deposited after four cycles of alternate soaking in the scaffolds were about 52%. The Ca/P ratio of hydroxyapatite/Thai silk fibroin and hydroxyapatite/ conjugated gelatin/Thai silk fibroin scaffolds prepared from 4 cycles of alternate soaking were 1.71 and 1.51, respectively. The results on in vitro culture using bone-marrow derived mesenchymal stem cells showed that conjugated gelatin/Thai silk fibroin scaffold prepared from 1.0wt% gelatin concentration effectively enhanced osteogenic differentiation similar to the scaffolds containing hydroxyapatite as evaluated by alkaline phosphatase activity, calcium content and the morphology of cultured cell on the scaffold surface. The results on the physical and biological properties of hydroxyapatite/conjugated gelatin/Thai silk fibroin scaffolds markedly indicated that the scaffolds had a high potential to be applied in tissue engineering.
DOI: 10.14457/cu.the.2009.1667
title: The effects of recombinant Oct4 and Sox2 proteins on pluripotent genes expression in mouse somatic cells

description: Mouse and human somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by reretroviral transducing genes encoding four transcription factors: Oct4, Sox2, Klf4 and c-Myc. This provided an opportunity to generate patient-specific pluripotent stem cells for human therapeutic and research application. However, a major limitation of this technology is the viral genome integration. In this study we demonstrated that recombinant protein Oct-4, one of the four key factors for reprogramming, containing protein transduction domain can pass through somatic cell membrane when added to the culture media. Treating mouse embryonic fibroblast with recombinant Oct-4 protein resulted in an activation of Nanog-luciferase reporter. Surprisingly, when using Tat-Oct4 protein combine with three retroviral vectors: Sox2, Klf4 and c-Myc, could be generated iPS colonies from primary mouse fibroblasts. These results suggest that the recombinant Oct-4 protein is active and may be used to substitute viral vector in iPS cell generation.
DOI: 10.14457/cu.the.2009.1668
title: Comparison and prediction of retention of disubstituted aromatic compounds in capillary electrokinetic chromatography

description: Retention index (I), rather than retention factor (k) was found to be a more reasonable parameter for comparison of the relative affinity of disubstituted benzenes in MEEKC and MEKC, due to independent of I with the SDS surfactant concentration. MEKC and MEEKC may give similar or different I values, depending on types of moieties. With known I and Kow for alkylbenzenes as references in MEKC and MEEKC, the values of log Kow for disubstituted benzenes can be estimated from the observed I values, where Kow is the octanol-water distribution constant. In addition, a group additive approach can be used to predict I for disubstituted benzenes with different moieties from the average observed I for the disubstituted benzenes with the same moieties. However, electronic effects and/or intramolecular interaction may result in the different observed I from prediction.
DOI: 10.14457/cu.the.2009.1669
title: Factors related to sexual abstinence among Thai female middle adolescents

description: To identify the predicting factors of sexual abstinence among Thai female middle adolescents. Pender’s Health Promotion Model guided to select the factors in the study. The participants in this study were 1,360 female students from high schools in Thailand. The participants completed 8 self–administered questionnaires. Independent variables were perceived benefits of sexual abstinence, perceived barriers to sexual abstinence, perceived sexual abstinence self–efficacy, parental influence, peer influence, and commitment to a plan of sexual abstinence. The dependent variable was sexual abstinence. Chi–square and multiple forward stepwise logistic regression analysis were conducted to analyze the data. The results showed that all independent variables had relation with sexual abstinence. Perceived sexual abstinence self–efficacy and peer influence were significantly positive predictors of sexual abstinence, at the .05 level (B = .149 and .048). Whereas, parental influence was significantly negative predictor of sexual abstinence, at the .05 level (B = -.064). The predictors could explain 29.3% of the variance and could correctly classify for 88.9%. The equation of logistic regression for explaining the variables of sexual abstinence was as follow: Sexual abstinence = -3.25 + .149 (Perceived sexual abstinence self-efficacy) + .048(Peer influence) - .064 (Parental influence).