cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.2909/905b4530-081d-4d9b-8601-268ea644cdf7
title: Reference Land Cover Change in Great Limpopo 2000-2015 (vector) - version 1, April 2019

description: This metadata refers to the Land Cover Change vector data generated over Limpopo (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. 
This area of interest is either mapped with the generic 8 classes dichotomus legend (SAF_02_lcc_a) or the detailed modular legend (SAF_02_lcc_b).

The mapped area of interest (AOI) represents a Key Landscape for Conservation area (KLC). The Great Limpopo trans frontier park involves three different parks: Kruger National Park (South Africa), Limpopo National Park (Mozambique) and Gonarezhou National Park (Zimbabwe). The memorandum of understanding for the creation of conservation area was signed on November 2000.
The floodplains of the Limpopo River are fertile and heavily populated. The southern hemisphere sees its rainy season, where precipitation exceeds 60 mm, roughly from October to March, and its dry one from around April to September. The area around the park is dense of villages and the agriculture is the primary activity.

Reference time: 2000 - 2015
DOI: 10.2909/328b3d4a-b778-4d63-9f34-8a5ea140c2ae
title: Reference Land Cover Change in Great Virunga 2000-2016 (vector) - version 1, Feb. 2019

description: This metadata refers to the Land Cover Change vector data generated over Virunga (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. This area of interest is either mapped with the generic 8 classes dichotomus legend (CAF_02_lcc_a) or the detailed modular legend (CAF_02_lcc_b).

The mapped area of interest (AOI) represents a Key Landscape for Conservation area (KLC). The KLC has a total size of about 4 million ha (40,000 km²) and is situated at the border between the Democratic Republic of Congo (DRC), Uganda and Rwanda. The main national park is represented by the Virunga National Park, with a total area of 7768.93 km². Several parks in Rwanda and Uganda are adjacent and connected to Virunga

Reference time: 2000 - 2016
DOI: 10.15468/dl.h5kasa
title: Occurrence Download

description: A dataset containing 774 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Symphytum asperum",
 "Country is Norway",
 "HasCoordinate is true"
 ]
}

 The dataset includes 774 records from 22 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028804-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.amgykc
title: Occurrence Download

description: A dataset containing 406 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Castanopsis jucunda"
 ]
}

 The dataset includes 406 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028803-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.2909/db8f7f70-77b2-43fc-bc39-7cc5b15dfc7a
title: Reference Land Cover Change in Great Virunga 2016-2019 (vector) - version 1, Feb. 2019

description: This metadata refers to the Land Cover Change vector data generated over Virunga (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. This area of interest is either mapped with the generic 8 classes dichotomus legend (CAF_02_lcc_a) or the detailed modular legend (CAF_02_lcc_b).

The mapped area of interest (AOI) represents a Key Landscape for Conservation area (KLC). The KLC has a total size of about 4 million ha (40,000 km²) and is situated at the border between the Democratic Republic of Congo (DRC), Uganda and Rwanda. The main national park is represented by the Virunga National Park, with a total area of 7768.93 km². Several parks in Rwanda and Uganda are adjacent and connected to Virunga

Reference time: 2016 - 2019
DOI: 10.15468/dl.vnfvmh
title: Occurrence Download

description: A dataset containing 71 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Symphytum asperum",
 "Country is United States of America",
 "HasCoordinate is true"
 ]
}

 The dataset includes 71 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028805-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.2909/0158d9e9-3cd4-4205-b955-18e89f479f35
title: Reference Land Cover Change in Kundelungu-Upemba 2000-2016 (vector) - version 1, Nov. 2019

description: This metadata refers to the Land Cover Change vector data generated over Kundelungu-Upemba (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. This area of interest is either mapped with the generic 8 classes dichotomus legend (CAF_11_lcc_a) or the detailed modular legend (CAF_11_lcc_b) .

The mapped area of interest (AOI) represents a key landscape for conservation area (KLC).

The KLC has a total size of 4,731,810 ha (47,318.1 km²) and is comprised by the Kundelungu Upemba National Parks complex. The Upemba National Park in the northern part of the KLC has a reported area of 1,367,365 ha (13,673.65 km²) while the Kundelungu National Park in the southern sector of the KLC has an area of 823,636 ha (8236.36 km²).

Reference time: 2000 - 2016
DOI: 10.5517/ccdc.csd.cc2mbsg7
title: CCDC 2423439: Experimental Crystal Structure Determination

description: Related Article: Li-bin Gao, Chun-peng Yang|2025|Polyhedron|279|117644|doi:10.1016/j.poly.2025.117644
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.17632/c2x8rynybg
title: Tomato Disease Dataset

description: This dataset comprises 1,026 images of tomato plants affected by viral diseases, gray mold, and bacterial wilt, with a total data volume of approximately 3.14 GB. The images were captured from multiple angles and distances to comprehensively reflect the multi-scale phenotypic characteristics of the diseases. Under the guidance of plant pathology experts, all images were manually annotated using the LabelImg tool, with labeled regions including leaves, fruits, and stems. Each image is accompanied by a corresponding XML-format annotation file. The dataset is well-suited for tasks such as disease classification, object detection, and plant phenotyping. It can support the training of deep learning models and holds promise for applications in cross-crop transfer learning.
DOI: 10.17632/c2x8rynybg.1
title: Tomato Disease Dataset

description: This dataset comprises 1,026 images of tomato plants affected by viral diseases, gray mold, and bacterial wilt, with a total data volume of approximately 3.14 GB. The images were captured from multiple angles and distances to comprehensively reflect the multi-scale phenotypic characteristics of the diseases. Under the guidance of plant pathology experts, all images were manually annotated using the LabelImg tool, with labeled regions including leaves, fruits, and stems. Each image is accompanied by a corresponding XML-format annotation file. The dataset is well-suited for tasks such as disease classification, object detection, and plant phenotyping. It can support the training of deep learning models and holds promise for applications in cross-crop transfer learning.
DOI: 10.15468/dl.7whc93
title: Occurrence Download

description: A dataset containing 300 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lobelia gregoriana",
 "HasCoordinate is true",
 "Geometry POLYGON ((-17.66889 -35.11691, 51.34702 -35.11691, 51.34702 37.62, -17.66889 37.62, -17.66889 -35.11691))"
 ]
}

 The dataset includes 300 records from 13 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028806-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.nedf7x
title: Occurrence Download

description: A dataset containing 346 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cirsium vulgare",
 "Country is Japan",
 "HasCoordinate is true"
 ]
}

 The dataset includes 346 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028808-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5517/ccdc.csd.cc2n3s9w
title: CCDC 2446498: Experimental Crystal Structure Determination

description: Related Article: Xian-Rui Zhang, Xiao-Han Zhang, Xian-Ying Xie, Jia-Yu Luo, Hui-Jun Chen, Lei Gao|2025|J.Mol.Struct.|1346|143196|doi:10.1016/j.molstruc.2025.143196
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.5517/ccdc.csd.cc2n3sbx
title: CCDC 2446499: Experimental Crystal Structure Determination

description: Related Article: Xian-Rui Zhang, Xiao-Han Zhang, Xian-Ying Xie, Jia-Yu Luo, Hui-Jun Chen, Lei Gao|2025|J.Mol.Struct.|1346|143196|doi:10.1016/j.molstruc.2025.143196
description: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
DOI: 10.15468/dl.muxwra
title: Occurrence Download

description: A dataset containing 63975 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 "BasisOfRecord is one of (Human Observation, Machine Observation, Occurrence evidence, Observation)",
 "TaxonKey is one of (Melierax canorus)",
 "Country is one of (Algeria, Angola, Benin, Botswana, British Indian Ocean Territory, Burkina Faso, Burundi, Cabo Verde, Cameroon, Central African Republic, Chad, Comoros, Congo, Congo, Democratic Republic of the, Côte d’Ivoire, Djibouti, Egypt, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, French Southern Territories, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Lesotho, Liberia, Libya, Madagascar, Malawi, Mali, Mauritania, Mauritius, Mayotte, Morocco, Mozambique, Namibia, Niger, Nigeria, Réunion, Rwanda, Saint Helena, Ascension and Tristan da Cunha, Sao Tome and Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Africa, South Sudan, Sudan, Tanzania, United Republic of, Togo, Tunisia, Uganda, Western Sahara, Zambia, Zimbabwe)"
 ]
}

 The dataset includes 63975 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028780-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.2909/57b094f8-2a83-4e4a-9c9f-537c5238ef45
title: Reference Land Cover Change in Kundelungu-Upemba 2016-2019 (vector) - version 1, Nov. 2019

description: This metadata refers to the Land Cover Change vector data generated over Kundelungu-Upemba (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. This area of interest is either mapped with the generic 8 classes dichotomus legend (CAF_11_lcc_a) or the detailed modular legend (CAF_11_lcc_b) .

The mapped area of interest (AOI) represents a key landscape for conservation area (KLC).

The KLC has a total size of 4,731,810 ha (47,318.1 km²) and is comprised by the Kundelungu Upemba National Parks complex. The Upemba National Park in the northern part of the KLC has a reported area of 1,367,365 ha (13,673.65 km²) while the Kundelungu National Park in the southern sector of the KLC has an area of 823,636 ha (8236.36 km²).

Reference time: 2016 - 2019
DOI: 10.6084/m9.figshare.29618639
title: Table 1: Summary of Previous Research on AI in Nigerian Business Sectors

description: Table 1: Summary of Previous Research on AI in Nigerian Business Sectors
DOI: 10.6084/m9.figshare.29618639.v1
title: Table 1: Summary of Previous Research on AI in Nigerian Business Sectors

description: Table 1: Summary of Previous Research on AI in Nigerian Business Sectors
DOI: 10.2909/e6f85d78-80ce-4971-bd71-bc29b0349d7f
title: Reference Land Cover Change in Lomami 2000-2015 (vector) - version 1, Sep. 2019

description: This metadata refers to the Land Cover Change vector data generated over Lomami (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. This area of interest is either mapped with the generic 8 classes dichotomus legend (CAF_15_lcc_a) or the detailed modular legend (CAF_15_lcc_b).

The mapped area of interest (AOI) represents a Key Landscape for Conservation area (KLC). It is situated in the central part of the Democratic Republic of Congo (DRC). The KLC has a total size of about 3.1 million ha (31,000 km²), while the Lomami National Park within the KLC has a total area of 8,873 km².
The Lomami National Park is the most recent established park in DRC, created in 2016. The park lies in the mostly undiscovered Lomami rainforest basin with very little human settlements and activities. Tropical lowland forest, savannah islands and riverine forest characterise the area. The park is rich in wildlife including large national endemic mammals such as okapi, the Congolese bonobo and a newly discovered monkey species named lesula (cercopithecus lomamiensis). Prior to park establishment the outer forests were mostly depleted of large animals by the commercial bushmeat trade (causing the nearly local extinction of the forest elephant in the southern part of the park). (https://www.congonationalparks.com/places/lomami-national-park/).

Reference time: 2000 - 2015
DOI: 10.15468/dl.hhufyh
title: Occurrence Download

description: A dataset containing 11624 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Lepus saxatilis, Aliger gigas)"
 ]
}

 The dataset includes 11624 records from 176 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028807-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.2909/f3fb027c-f8d0-426f-be7a-dcc8ae94c24a
title: Reference Land Cover Change in Luangwa 2000-2015 (vector) - version 1, March 2018

description: This metadata refers to the Land Cover Change vector data generated over Luangwa (Africa) in the framework of the Copernicus Global Land Hot Spot Mapping (C-GL-HSM) contract under the coordination of JRC. This area of interest is either mapped with the generic 8 classes dichotomus legend (SAF_14_15_lcc_a).

The mapped area of interest (AOI) represents a Key Landscape for Conservation area (KLC). The KLC has a total size of 3,5 million ha (35,000 km²) and is located in the eastern part of Zambia, at the end of the Great African Rift Valley System. The two National Parks have been established in 1971 and have a combined reported area of 1,368,600 ha (13,686 km²), 905,000 ha for South Luangwa and 463,600 ha for North Luangwa. The parks are within the central Zambezian and southern Miombo woodlands and Zambezian and Mopane woodlands and are characterized by the Luangwa River in the east and the Muchinga Escarpment in the west.

Reference time: 2000 - 2015
DOI: 10.15468/dl.x6kueh
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rattus norvegicus",
 "Country is Iceland",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028810-250717081556266/datasets/export for details.
DOI: 10.15468/dl.jycqr3
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Carthamus tinctorius",
 "Country is Argentina",
 "HasCoordinate is true"
 ]
}

 The dataset includes 27 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028811-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mvbsy8
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Rattus norvegicus",
 "Country is Guyana",
 "HasCoordinate is true"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0028809-250717081556266/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5281/zenodo.16322736
title: Dataset on multiattribute decision-making supporting secondary data analysis.
DOI: 10.5281/zenodo.16322737
title: Dataset on multiattribute decision-making supporting secondary data analysis.
DOI: 10.17632/5x624hg88m
title: Inhibitory effect of Wogonin on hepatocellular carcinoma through modulation of lactate metabolism and suppression of regulatory T cell differentiation[]

description: Abstract
Background: Wogonin, an active flavonoid derived from the traditional Chinese medicinal (TCM) herb Scutellaria baicalensis, has been reported to regulate cellular metabolism. Increasing evidence indicates that wogonin may inhibit regulatory T cell (Treg) differentiation and modulate immune responses both in vivo and in vitro. However, the specific molecular mechanisms remain unclear. Our previous findings demonstrated that lactic acid, a metabolic byproduct of glycolysis in hepatocellular carcinoma (HCC) cells, promotes differentiation of naïve CD4+ T cells into Tregs.
Objective: To investigate the molecular mechanisms underlying the anti-HCC effects of wogonin, particularly its impact on lactate metabolism and Treg differentiation.
Methods: The effects of wogonin (1.25, 5, and 20 μg/mL) on naïve CD4+ T-cell differentiation were assessed in the presence of lactic acid. Treg proportions were measured using flow cytometry, while protein and mRNA expression levels of TGF-β, p-Smad2, p-Smad3, LDHA, p-mTOR, HIF-1α, ATP5B, and FOXP3 were analyzed by Western blotting and RT-PCR. Levels of IL-10, α-KG, and 2HG were quantified using ELISA. To further assess in vivo efficacy, a mouse hepatoma transplantation model was established via subcutaneous injection of H22 cells. After 7 days, mice received wogonin treatments (12.5 or 25 mg/kg). Three weeks later, mice were euthanized, tumors were histologically analyzed using HE is staining, CD4+ and CD8+ T-cell populations were assessed by immunohistochemistry and flow cytometry, LDHA enzyme activity and intra- and extracellular lactate and glucose concentrations were determined by ELISA, and Foxp3 and IL-10 mRNA levels were measured by RT-PCR.
Results: Upon cytokine stimulation (anti-CD3, anti-CD28, and TGF-β) with supplemental lactic acid, the proportion of Treg cells was significantly elevated. Conversely, treatment with wogonin significantly and dose-dependently decreased Treg differentiation and simultaneously inhibited LDHA expression. Through inhibitor screening, c-Myc was identified as a crucial molecular target of wogonin. Mechanistically, wogonin suppressed c-Myc activity, thereby downregulating LDHA expression and activity, reducing abnormal accumulation of 2HG, normalizing the 2HG/α-KG ratio, and ultimately attenuating the expression of the Treg-specific transcription factor Foxp3 and cytokine IL-10.
Conclusion: Wogonin suppresses Treg cell differentiation and exhibits anti-HCC effects by inhibiting c-Myc-mediated LDHA expression and disrupting the 2HG/ATP5B/mTOR/HIF-1α signaling pathway. Given its potential to reshape the immunosuppressive tumor microenvironment, we propose further investigation into the synergistic therapeutic effects of wogonin in combination with PD-1/PD-L1 inhibitors.
DOI: 10.17632/5x624hg88m.1
title: Inhibitory effect of Wogonin on hepatocellular carcinoma through modulation of lactate metabolism and suppression of regulatory T cell differentiation[]

description: Abstract
Background: Wogonin, an active flavonoid derived from the traditional Chinese medicinal (TCM) herb Scutellaria baicalensis, has been reported to regulate cellular metabolism. Increasing evidence indicates that wogonin may inhibit regulatory T cell (Treg) differentiation and modulate immune responses both in vivo and in vitro. However, the specific molecular mechanisms remain unclear. Our previous findings demonstrated that lactic acid, a metabolic byproduct of glycolysis in hepatocellular carcinoma (HCC) cells, promotes differentiation of naïve CD4+ T cells into Tregs.
Objective: To investigate the molecular mechanisms underlying the anti-HCC effects of wogonin, particularly its impact on lactate metabolism and Treg differentiation.
Methods: The effects of wogonin (1.25, 5, and 20 μg/mL) on naïve CD4+ T-cell differentiation were assessed in the presence of lactic acid. Treg proportions were measured using flow cytometry, while protein and mRNA expression levels of TGF-β, p-Smad2, p-Smad3, LDHA, p-mTOR, HIF-1α, ATP5B, and FOXP3 were analyzed by Western blotting and RT-PCR. Levels of IL-10, α-KG, and 2HG were quantified using ELISA. To further assess in vivo efficacy, a mouse hepatoma transplantation model was established via subcutaneous injection of H22 cells. After 7 days, mice received wogonin treatments (12.5 or 25 mg/kg). Three weeks later, mice were euthanized, tumors were histologically analyzed using HE is staining, CD4+ and CD8+ T-cell populations were assessed by immunohistochemistry and flow cytometry, LDHA enzyme activity and intra- and extracellular lactate and glucose concentrations were determined by ELISA, and Foxp3 and IL-10 mRNA levels were measured by RT-PCR.
Results: Upon cytokine stimulation (anti-CD3, anti-CD28, and TGF-β) with supplemental lactic acid, the proportion of Treg cells was significantly elevated. Conversely, treatment with wogonin significantly and dose-dependently decreased Treg differentiation and simultaneously inhibited LDHA expression. Through inhibitor screening, c-Myc was identified as a crucial molecular target of wogonin. Mechanistically, wogonin suppressed c-Myc activity, thereby downregulating LDHA expression and activity, reducing abnormal accumulation of 2HG, normalizing the 2HG/α-KG ratio, and ultimately attenuating the expression of the Treg-specific transcription factor Foxp3 and cytokine IL-10.
Conclusion: Wogonin suppresses Treg cell differentiation and exhibits anti-HCC effects by inhibiting c-Myc-mediated LDHA expression and disrupting the 2HG/ATP5B/mTOR/HIF-1α signaling pathway. Given its potential to reshape the immunosuppressive tumor microenvironment, we propose further investigation into the synergistic therapeutic effects of wogonin in combination with PD-1/PD-L1 inhibitors.