cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.11839794
title: Overcoming the challenges to offer quality training in psychiatric nursing

description: ABSTRACT Objective: to report the experience of the Psychiatric Nursing professors of the Nursing Undergraduate Course of the Nursing School, Universidade Federal de Minas Gerais (UFMG) and the challenges faced to offer quality training. Method: This is an experience report about the experience of Psychiatric Nursing professors of the Nursing Undergraduate Course of the Nursing School, UFMG. Results: After losing the workload of 120 hours in the Psychiatric Nursing Undergraduate Course, the area developed elective disciplines with a total of 330-hour load, in addition to extension and research projects. Final considerations: the precariousness of the area of Nursing training after curricular restructuring in a higher education institution, whether in relation to hour load or in the allocation of teaching vacancies, is in line with advances of the Brazilian Psychiatric Reform and epidemiological data of psychic illness and drug use.
DOI: 10.6084/m9.figshare.11839797.v1
title: Plays and games of Pantanal children: a study in an “escola das águas””

description: Abstract In the city of Corumbá, Pantanal, there is a group of schools called “Schools of Water,” so called because they are in regions difficult to access and are influenced by the water cycle of Pantanal. The present article discusses the results of a doctoral study that analyzed the ludic culture of the children in one of these schools. The study was carried out with 33 children, in a school context, and involved observations, interviews, and drawings about games produced by children at the researcher’s request. The data were submitted to content analysis and categorized into two thematic axes: 1. Type of game; 2. Media in the ludic culture. The results indicate strong similarities between the play culture of Pantanal children and that of children from other regions of Brazil, and little presence of Pantanal culture in the ludic activities developed by the children in the school.
DOI: 10.6084/m9.figshare.11839800.v1
title: Research in nursing and modification of the knowledge tree in CNPq: contribution to science

description: ABSTRACT Objective: to identify funding demands in the light of CNPq’s knowledge subareas, as well as data on researchers and research groups, their distribution in the regions and their approximation with health research priorities of the Ministry of Health and the new knowledge tree framework of the area. Method: a descriptive study developed with data from 2009 to 2014 about researchers, funding and research areas provided by the Diretoria de Ciências Agrárias Biológicas e Saúde (Department of Agriculture, Biology and Health Sciences). Results: there is a concentration of researchers and research groups in the Southeast region. The research priorities in the health field most frequently addressed were: Noncommunicable Diseases, Child and Adolescent Health, Women’s Health and Communicable diseases. The grants could be classified in the current framework of knowledge areas. Final considerations: this analysis enabled visualizing subarea demands and relevance of changing the nomenclature of the classification of knowledge framework in order to represent the scientific production generated in the nursing area.
DOI: 10.6084/m9.figshare.11839788
title: Abortion and health in Brazil: challenges to research within a context of illegality

description: Abortion research faces great challenges, even more so in contexts in which it is illegal. Women tend to omit the voluntary termination of pregnancy or to declare having miscarried, which results in an underestimation of abortions. Research on this subject is indispensable because it enables us to estimate the incidence of abortion and its complications, and to identify unmet demands and more vulnerable groups so as to subsidize health actions and policies. In this article, we seek to describe the main challenges faced by researchers through a review of original studies on abortion and our reflections based on empirical studies we have conducted. We discuss the difficulties in obtaining information, strategies and techniques used to increase accuracy and reliability and their limits and advantages, and strategies for estimating the occurrence of abortion and its complications, using direct (interviews and data from medical charts) and indirect (secondary data on mortality and morbidity) methods. When investigating abortion complications, we address studies on mortality and morbidity, emphasizing the specificities of abortion among obstetric causes. We discuss the main indicators used by researchers and methodological aspects of their construction. We make recommendations for overcoming methodological problems and conducting new studies. In the conclusion, we reiterate the relevance of research on abortion and the need for approaches that contemplate its complexity.
DOI: 10.6084/m9.figshare.11839791
title: Crystallographic Texture Evolution of Aluminum Alloy 3104 in the Drawn and Wall Ironing (DWI) Process

description: Aluminum beverage cans should have very specific crystallographic textures to increase productivity, reduce losses and reduce the amount of material. The present work seeks to add information on the crystallographic texture of aluminum alloy 3104 H-19 during the different manufacturing steps, which undergoes a flat sheet of metal for a cylindrical body. The work scope encompasses from the cup drawing to the final ironing operation and its objective is to add information on the texture evolution of the aluminum alloy undergoes in the intermediary steps. Crystallographic texture continues to change from the drawn cup through the ironing stages. This rotation is assumed to be a grain alignment with the plastic flow of the material.
DOI: 10.6084/m9.figshare.11839794.v1
title: Overcoming the challenges to offer quality training in psychiatric nursing

description: ABSTRACT Objective: to report the experience of the Psychiatric Nursing professors of the Nursing Undergraduate Course of the Nursing School, Universidade Federal de Minas Gerais (UFMG) and the challenges faced to offer quality training. Method: This is an experience report about the experience of Psychiatric Nursing professors of the Nursing Undergraduate Course of the Nursing School, UFMG. Results: After losing the workload of 120 hours in the Psychiatric Nursing Undergraduate Course, the area developed elective disciplines with a total of 330-hour load, in addition to extension and research projects. Final considerations: the precariousness of the area of Nursing training after curricular restructuring in a higher education institution, whether in relation to hour load or in the allocation of teaching vacancies, is in line with advances of the Brazilian Psychiatric Reform and epidemiological data of psychic illness and drug use.
DOI: 10.6084/m9.figshare.11839785
title: Non-mosaic partial duplication 12p in a patient with dysmorphic characteristics and developmental delay

description: Abstract Duplication of the short arm of chromosome 12 is a rare chromosomal abnormality that may arise de novo or result from malsegregation of a balanced parental translocation. This study comprises the clinical description, cytogenetic and cytogenomic analyses and genotype-phenotype correlation in a patient with facial dysmorphism, developmental delay and intellectual impairment caused by non-mosaic partial duplication and a paracentric inversion 12p. The patient’s GTG-banded karyotype was 46,XX,invdup(12)(pter → p13.32::p11.1 → p13.31::p13.31 → qter). A genetic gain of approximately 28 Mb was detected in the chromosomal region arr[GRCh37]12p13.31-p11.1(6914072_34756209)x3. The chromosomal alteration seen in our patient is described as “pure” partial duplication 12p. In most cases, duplication 12p phenotype is characterized by dysmorphic features, multiple congenital anomalies and intellectual disability. A small number of cases in literature have described genes associated with neurodevelopmental disease, such as ING4, CHD4, MFAP5, GRIN2B, SOX5, SCN8A and PIANP. In our patient the duplication 12p was de novo. This study should contribute to the genotype-phenotype correlation in partial duplication 12p cases.
DOI: 10.6084/m9.figshare.11839788.v1
title: Abortion and health in Brazil: challenges to research within a context of illegality

description: Abortion research faces great challenges, even more so in contexts in which it is illegal. Women tend to omit the voluntary termination of pregnancy or to declare having miscarried, which results in an underestimation of abortions. Research on this subject is indispensable because it enables us to estimate the incidence of abortion and its complications, and to identify unmet demands and more vulnerable groups so as to subsidize health actions and policies. In this article, we seek to describe the main challenges faced by researchers through a review of original studies on abortion and our reflections based on empirical studies we have conducted. We discuss the difficulties in obtaining information, strategies and techniques used to increase accuracy and reliability and their limits and advantages, and strategies for estimating the occurrence of abortion and its complications, using direct (interviews and data from medical charts) and indirect (secondary data on mortality and morbidity) methods. When investigating abortion complications, we address studies on mortality and morbidity, emphasizing the specificities of abortion among obstetric causes. We discuss the main indicators used by researchers and methodological aspects of their construction. We make recommendations for overcoming methodological problems and conducting new studies. In the conclusion, we reiterate the relevance of research on abortion and the need for approaches that contemplate its complexity.
DOI: 10.6084/m9.figshare.11839791.v1
title: Crystallographic Texture Evolution of Aluminum Alloy 3104 in the Drawn and Wall Ironing (DWI) Process

description: Aluminum beverage cans should have very specific crystallographic textures to increase productivity, reduce losses and reduce the amount of material. The present work seeks to add information on the crystallographic texture of aluminum alloy 3104 H-19 during the different manufacturing steps, which undergoes a flat sheet of metal for a cylindrical body. The work scope encompasses from the cup drawing to the final ironing operation and its objective is to add information on the texture evolution of the aluminum alloy undergoes in the intermediary steps. Crystallographic texture continues to change from the drawn cup through the ironing stages. This rotation is assumed to be a grain alignment with the plastic flow of the material.
DOI: 10.6084/m9.figshare.11839782
title: The theme of violence in nursing theses from the view of technological toolboxes

description: ABSTRACT Objective: To characterize the data gathering technological tools used in nursing theses on violence from the view of “technological toolboxes”. Method: It is a descriptive and documental study, with a qualitative approach, based on Thesis available in the last ten volumes of the Catalogue of Theses and Dissertations of the Center of Nursing Studies and Research (CEPEn). Documents presenting technological tools during the data gathering of its studies were selected, and then classified using “technological toolboxes” according to Merhy. Results: 30 theses were selected, data gathering tools were classified in “technological toolboxes” as lightweight, light-hard, and hard technologies, with uniformity in most researches (23; 76.6%). Conclusion: Given it is a multifaced phenomenon, violence demands a deeper view, using the most diverse tools for its proper understanding and classification.
DOI: 10.6084/m9.figshare.11839785.v1
title: Non-mosaic partial duplication 12p in a patient with dysmorphic characteristics and developmental delay

description: Abstract Duplication of the short arm of chromosome 12 is a rare chromosomal abnormality that may arise de novo or result from malsegregation of a balanced parental translocation. This study comprises the clinical description, cytogenetic and cytogenomic analyses and genotype-phenotype correlation in a patient with facial dysmorphism, developmental delay and intellectual impairment caused by non-mosaic partial duplication and a paracentric inversion 12p. The patient’s GTG-banded karyotype was 46,XX,invdup(12)(pter → p13.32::p11.1 → p13.31::p13.31 → qter). A genetic gain of approximately 28 Mb was detected in the chromosomal region arr[GRCh37]12p13.31-p11.1(6914072_34756209)x3. The chromosomal alteration seen in our patient is described as “pure” partial duplication 12p. In most cases, duplication 12p phenotype is characterized by dysmorphic features, multiple congenital anomalies and intellectual disability. A small number of cases in literature have described genes associated with neurodevelopmental disease, such as ING4, CHD4, MFAP5, GRIN2B, SOX5, SCN8A and PIANP. In our patient the duplication 12p was de novo. This study should contribute to the genotype-phenotype correlation in partial duplication 12p cases.
DOI: 10.6084/m9.figshare.11839779
title: Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges

description: Abstract Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that regulates the gene expression of several target genes. These factors are activated by the binding of cytokines and growth factors with STAT-3 specific receptors on cell membrane. Few years ago, STAT-3 was considered an acute phase response element having several cellular functions such as inflammation, cell survival, invasion, metastasis and proliferation, genetic alteration, and angiogenesis. STAT-3 is activated by several types of inflammatory cytokines, carcinogens, viruses, growth factors, and oncogenes. Thus, the STAT3 pathway is a potential target for cancer therapeutics. Abnormal STAT-3 activity in tumor development and cellular transformation can be targeted by several genomic and pharmacological methodologies. An extensive review of the literature has been conducted to emphasize the role of STAT-3 as a unique cancer drug target. This review article discusses in detail the wide range of STAT-3 inhibitors that show antitumor effects both in vitro and in vivo. Thus, targeting constitutive STAT-3 signaling is a remarkable therapeutic methodology for tumor progression. Finally, current limitations, trials and future perspectives of STAT-3 inhibitors are also critically discussed.
DOI: 10.6084/m9.figshare.11839782.v1
title: The theme of violence in nursing theses from the view of technological toolboxes

description: ABSTRACT Objective: To characterize the data gathering technological tools used in nursing theses on violence from the view of “technological toolboxes”. Method: It is a descriptive and documental study, with a qualitative approach, based on Thesis available in the last ten volumes of the Catalogue of Theses and Dissertations of the Center of Nursing Studies and Research (CEPEn). Documents presenting technological tools during the data gathering of its studies were selected, and then classified using “technological toolboxes” according to Merhy. Results: 30 theses were selected, data gathering tools were classified in “technological toolboxes” as lightweight, light-hard, and hard technologies, with uniformity in most researches (23; 76.6%). Conclusion: Given it is a multifaced phenomenon, violence demands a deeper view, using the most diverse tools for its proper understanding and classification.
DOI: 10.6084/m9.figshare.11839779.v1
title: Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges

description: Abstract Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that regulates the gene expression of several target genes. These factors are activated by the binding of cytokines and growth factors with STAT-3 specific receptors on cell membrane. Few years ago, STAT-3 was considered an acute phase response element having several cellular functions such as inflammation, cell survival, invasion, metastasis and proliferation, genetic alteration, and angiogenesis. STAT-3 is activated by several types of inflammatory cytokines, carcinogens, viruses, growth factors, and oncogenes. Thus, the STAT3 pathway is a potential target for cancer therapeutics. Abnormal STAT-3 activity in tumor development and cellular transformation can be targeted by several genomic and pharmacological methodologies. An extensive review of the literature has been conducted to emphasize the role of STAT-3 as a unique cancer drug target. This review article discusses in detail the wide range of STAT-3 inhibitors that show antitumor effects both in vitro and in vivo. Thus, targeting constitutive STAT-3 signaling is a remarkable therapeutic methodology for tumor progression. Finally, current limitations, trials and future perspectives of STAT-3 inhibitors are also critically discussed.
DOI: 10.6084/m9.figshare.11839770
title: Evaluation of bone availability for grafts in different donor sites, through computed tomography

description: Abstract Objective To quantify the bone volume that can be safely withdrawn from 3 donor sites: (1) the mandibular symphysis, (2) the oblique mandibular line and (3) the skullcap. Methodology For the symphysis, 200 tomographic exams were evaluated by the extension of the anterior loop of mental foramen, by the nerve, by the distance of the foramens, by the distance between the vestibular cortical and the lingual plates and by the distance between the apexes, or lower anterior teeth, and the mandibular base, using the “distance” tool of the I-CAT Vision, in the panoramic and parasagittal reformations. For the oblique line, 70 TCFC exams were analyzed retrospectively in panoramic and parasagittal reformations, evaluating the thickness of the vestibular cortical and the distance between the cortical and the mandibular canal. For the cranial bone, a hexagonal donor site located in parietal area was considered. Results The average dimensions of the bone blocks that can be safely removed from the region of the mandibular symphysis are: 32.27 mm in length, 4.87 mm in height and 4 mm in thickness, providing a volume of 628.61 mm3 available for grafting. In the oblique line, the available bone volume for grafting was 859.61 mm3. In the region of the cranial vault, multiplying the average bone thickness by the area of the hexagon, an average volume of 2,499 mm3 was obtained. Conclusions Comparing the donor sites, the bone availability in the cranial vault is 3 times greater than in the mandibular posterior region, and at least 2 times greater than in the mandibular symphysis.
DOI: 10.6084/m9.figshare.11839773
title: Biodegradable Compounds of Poly (Ɛ-Caprolactone)/Montmorillonite Clays

description: Biodegradable Poly (ɛ-caprolactone) (PCL) was compounded with Brasgel PA (MMT) and Cloisite Na (CLNa), and compatibilized with maleic anhydride grafted poly(ɛ-caprolactone) (PCL-g-MA). No evidence of degradation was verified during processing, as well as particle aggregates were absent as displayed through scanning electron microscopy (SEM) images. Compatibilized compounds upon clay addition achieved higher thermal stability as visualized by thermogravimetry (TG). Montmorillonite clays acted as nucleant agent during PCL melt crystallization as evidenced by differential scanning calorimetry (DSC). Mechanical behavior of PCL was preserved, and all compounds presented Elongation higher than 350% meanwhile the heat distortion temperature (HDT) was increased by 20% in PCL compounds, which may have wider range of application and better performance.
DOI: 10.6084/m9.figshare.11839773.v1
title: Biodegradable Compounds of Poly (Ɛ-Caprolactone)/Montmorillonite Clays

description: Biodegradable Poly (ɛ-caprolactone) (PCL) was compounded with Brasgel PA (MMT) and Cloisite Na (CLNa), and compatibilized with maleic anhydride grafted poly(ɛ-caprolactone) (PCL-g-MA). No evidence of degradation was verified during processing, as well as particle aggregates were absent as displayed through scanning electron microscopy (SEM) images. Compatibilized compounds upon clay addition achieved higher thermal stability as visualized by thermogravimetry (TG). Montmorillonite clays acted as nucleant agent during PCL melt crystallization as evidenced by differential scanning calorimetry (DSC). Mechanical behavior of PCL was preserved, and all compounds presented Elongation higher than 350% meanwhile the heat distortion temperature (HDT) was increased by 20% in PCL compounds, which may have wider range of application and better performance.
DOI: 10.6084/m9.figshare.11839767
title: Risk Factors for In-Hospital Mortality in Infective Endocarditis

description: Abstract Background: Infective endocarditis (IE) is associated with severe complications and high mortality. The assessment of mortality rates and predictors for fatal events is important to identify modifiable factors related to the pattern of treatment, in order to improve outcomes. Objectives: We sought to evaluate clinical outcomes of patients with IE and to determine predictors of in-hospital mortality. Methods: Retrospective single-center study including patients with IE admitted during a 10-year period (2006-2015). Data on comorbidities, clinical presentation, microbiology and clinical outcomes during hospitalization were evaluated. Risk factors of in-hospital death were analyzed. A p-value &lt; 0.05 was considered significant. Results: A total of 134 cases were included (73% males, mean age of 61 ± 16 years-old). Half of them had previous valvular heart disease. Healthcare-associated IE and negative blood-cultures occurred in 22% and prosthetic IE in 25%. The aortic valve was the one most often affected by infection. Staphylococcus aureus was the most commonly isolated microorganism. Forty-four (32.8%) patients underwent cardiac surgery. The in-hospital mortality rate was 31.3% (42 patients). The identified risk factors for in-hospital mortality were Staphylococcus aureus etiology (OR 6.47; 95% CI: 1.07-39.01; p = 0.042), negative blood-cultures (OR 9.14; 95% CI: 1.42-58.77; p = 0.02), evidence of valve obstruction in echocardiography (OR 8.57; 95% CI: 1.11-66.25; p = 0.039), clinical evolution with heart failure (OR 4.98; 95%CI: 1.31-18.92; p = 0.018) or septic shock (OR 20.26; 95% CI: 4.04-101.74; p &lt; 0.001). Cardiac surgery was a protective factor of mortality (OR 0.14; 95% CI 0.03-0.65; p = 0.012). Conclusion: The risk factors for in-hospital mortality were clinical (heart failure, septic shock), evidence of valve obstruction in echocardiography, Staphylococcus aureus etiology or negative blood cultures. Invasive treatment by surgery significantly decreased the mortality risk.
DOI: 10.6084/m9.figshare.11839764
title: Therapeutic follow-up and network intervention as a strategy in psychosocial care

description: ABSTRACT Objective: to analyze Therapeutic Follow-Up (TF) and Network Intervention (NI) as devices for social network/Psychosocial Care Center (CAPS - Centro de Atenção Psicossocial) user staff construction. Method: an ethnographic study. Data collection instruments were participant observation, field diary, semi-structured interviews and Sluzki’s Minimal Map of Relationships. The research site was at a CAPS II of the city of São Paulo. Participants were CAPS user, their family network, professionals and other users. Data analysis took place through Minayo’s thematic content analysis framework and Sluzki’s personal maps. Results: TF and NI led to greater social participation, autonomy and reorganization of family roles and treatment in CAPS. Conclusion: the TF associated with NI was potent in strengthening the user’s personal/social network and in including them in community activities.