cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.6009008.v1
title: Additional file 7: of Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander

description: Gene expression in representative immune pathways. Table S17. Gene expression level in the pathway “Hematopoietic cell lineage”. Table S18. Gene expression level in the pathway “Toll-like receptor signaling pathway”. Table S19. Gene expression level in the pathway “Complement and coagulation cascades”. Table S20. Gene expression level in the pathway “Antigen processing and presentation”. Table S21. Gene expression level in the pathway “Natural killer cell mediated cytotoxicity”. The log2(fold change) of each DEG assigned to corresponding pathway was shown. (ZIP 45 kb)
DOI: 10.6084/m9.figshare.6009026
title: Additional file 8: of Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander

description: Table S22. FPKM of all unigenes. (XLSX 14778Â kb)
DOI: 10.6084/m9.figshare.6009026.v1
title: Additional file 8: of Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander

description: Table S22. FPKM of all unigenes. (XLSX 14778Â kb)
DOI: 10.6084/m9.figshare.6011036
title: TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells

description: Store depletion has been shown to induce Ca<sup>2+</sup> entry by Na+/Ca+ exchange (NCX) 1 reversal in proliferative vascular smooth muscle cells (VSMCs). The study objective was to investigate the role of transient receptor potential canonical (TRPC) channels in store depletion and NCX1 reversal in proliferative VSMCs. In cultured VSMCs, expressing TRPC1, TRPC4, and TRPC6, the removal of extracellular Na<sup>+</sup> was followed by a significant increase of cytosolic Ca<sup>2+</sup> concentration that was inhibited by KBR, a selective NCX1 inhibitor. TRPC1 knockdown significantly suppressed store-operated, channel-mediated Ca<sup>2+</sup> entry, but TRPC4 knockdown and TRPC6 knockdown had no effect. Separate knockdown of TRPC1, TRPC4, or TRPC6 did not have a significant effect on thapsigargin-initiated Na<sup>+</sup> increase in the peripheral regions with KBR treatment, but knockdown of both TRPC4 and TRPC6 did. Stromal interaction molecule (STIM)1 knockdown significantly reduced TRPC4 and TRPC6 binding. The results demonstrated that TRPC4–TRPC6 heteromultimerization linked Ca<sup>2+</sup> store depletion and STIM1 accumulation with NCX reversal in proliferative VSMCs.
DOI: 10.6084/m9.figshare.6011036.v2
title: TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells

description: Store depletion has been shown to induce Ca<sup>2+</sup> entry by Na+/Ca+ exchange (NCX) 1 reversal in proliferative vascular smooth muscle cells (VSMCs). The study objective was to investigate the role of transient receptor potential canonical (TRPC) channels in store depletion and NCX1 reversal in proliferative VSMCs. In cultured VSMCs, expressing TRPC1, TRPC4, and TRPC6, the removal of extracellular Na<sup>+</sup> was followed by a significant increase of cytosolic Ca<sup>2+</sup> concentration that was inhibited by KBR, a selective NCX1 inhibitor. TRPC1 knockdown significantly suppressed store-operated, channel-mediated Ca<sup>2+</sup> entry, but TRPC4 knockdown and TRPC6 knockdown had no effect. Separate knockdown of TRPC1, TRPC4, or TRPC6 did not have a significant effect on thapsigargin-initiated Na<sup>+</sup> increase in the peripheral regions with KBR treatment, but knockdown of both TRPC4 and TRPC6 did. Stromal interaction molecule (STIM)1 knockdown significantly reduced TRPC4 and TRPC6 binding. The results demonstrated that TRPC4–TRPC6 heteromultimerization linked Ca<sup>2+</sup> store depletion and STIM1 accumulation with NCX reversal in proliferative VSMCs.
DOI: 10.6084/m9.figshare.6011036.v1
title: TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells.

description: Store depletion has been shown to induce Ca<sup>2+</sup> entry by Na+/Ca+ exchange (NCX) 1 reversal in proliferative vascular smooth muscle cells (VSMCs). The study objective was to investigate the role of transient receptor potential canonical (TRPC) channels in store depletion and NCX1 reversal in proliferative VSMCs. In cultured VSMCs, expressing TRPC1, TRPC4, and TRPC6, the removal of extracellular Na<sup>+</sup> was followed by a significant increase of cytosolic Ca<sup>2+</sup> concentration that was inhibited by KBR, a selective NCX1 inhibitor. TRPC1 knockdown significantly suppressed store-operated, channel-mediated Ca<sup>2+</sup> entry, but TRPC4 knockdown and TRPC6 knockdown had no effect. Separate knockdown of TRPC1, TRPC4, or TRPC6 did not have a significant effect on thapsigargin-initiated Na<sup>+</sup> increase in the peripheral regions with KBR treatment, but knockdown of both TRPC4 and TRPC6 did. Stromal interaction molecule (STIM)1 knockdown significantly reduced TRPC4 and TRPC6 binding. The results demonstrated that TRPC4–TRPC6 heteromultimerization linked Ca<sup>2+</sup> store depletion and STIM1 accumulation with NCX reversal in proliferative VSMCs.
DOI: 10.6084/m9.figshare.6014927
title: Additional file 1: of Experiences of ICU survivors in a low middle income country- a multicenter study

description: Data collection instrument. The data collection instrument contains the original questionnaire. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.6014927.v1
title: Additional file 1: of Experiences of ICU survivors in a low middle income country- a multicenter study

description: Data collection instrument. The data collection instrument contains the original questionnaire. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.6014930
title: Additional file 1: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S1. Summary of sequencing and de novo assembly of P. frutescens seed transcriptome. (XLS 21Â kb)
DOI: 10.6084/m9.figshare.6014930.v1
title: Additional file 1: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S1. Summary of sequencing and de novo assembly of P. frutescens seed transcriptome. (XLS 21Â kb)
DOI: 10.6084/m9.figshare.6014957
title: Additional file 11: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: Major genomic features of strains CR141 and CR147. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6014957.v1
title: Additional file 11: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: Major genomic features of strains CR141 and CR147. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6014960
title: Additional file 3: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S2. Summary of annotations for assembled unigenes in P. frutescens seed transcriptome. (XLS 21Â kb)
DOI: 10.6084/m9.figshare.6014960.v1
title: Additional file 3: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S2. Summary of annotations for assembled unigenes in P. frutescens seed transcriptome. (XLS 21Â kb)
DOI: 10.6084/m9.figshare.6014972
title: Additional file 12: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: Strain-specific CDSs determined by pairwise comparison. a The 40 CR141-specific CDSs as determined by comparison with CR147. b The 46 CR147-specific CDSs as determined by comparison with CR141. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.6014972.v1
title: Additional file 12: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: Strain-specific CDSs determined by pairwise comparison. a The 40 CR141-specific CDSs as determined by comparison with CR147. b The 46 CR147-specific CDSs as determined by comparison with CR141. (XLSX 12Â kb)
DOI: 10.6084/m9.figshare.6014987
title: Additional file 5: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S3. Differentially expressed genes involved in fatty acid biosynthesis and metabolism. (XLS 26Â kb)
DOI: 10.6084/m9.figshare.6014987.v1
title: Additional file 5: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S3. Differentially expressed genes involved in fatty acid biosynthesis and metabolism. (XLS 26Â kb)
DOI: 10.6084/m9.figshare.6014996
title: Additional file 6: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S4. KEGG pathway enrichment analysis of differentially expressed genes between 10 DAF and 5 DAF seeds. (XLS 58Â kb)
DOI: 10.6084/m9.figshare.6014996.v1
title: Additional file 6: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S4. KEGG pathway enrichment analysis of differentially expressed genes between 10 DAF and 5 DAF seeds. (XLS 58Â kb)
DOI: 10.6084/m9.figshare.6015014
title: Additional file 7: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S5. KEGG pathway enrichment analysis of differentially expressed genes between 20 DAF and 10 DAF seeds. (XLS 34Â kb)
DOI: 10.6084/m9.figshare.6015014.v1
title: Additional file 7: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S5. KEGG pathway enrichment analysis of differentially expressed genes between 20 DAF and 10 DAF seeds. (XLS 34Â kb)
DOI: 10.6084/m9.figshare.6015032
title: Additional file 8: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S7. List of differentially expressed TFs involved in fatty acid and TAG biosynthesis in Perilla seed. (XLS 13Â kb)
DOI: 10.6084/m9.figshare.6015032.v1
title: Additional file 8: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S7. List of differentially expressed TFs involved in fatty acid and TAG biosynthesis in Perilla seed. (XLS 13Â kb)
DOI: 10.6084/m9.figshare.6015044
title: Additional file 9: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S6. Gene-specific primers used in qRT-PCR. (XLS 31Â kb)
DOI: 10.6084/m9.figshare.6015044.v1
title: Additional file 9: of Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

description: Table S6. Gene-specific primers used in qRT-PCR. (XLS 31Â kb)
DOI: 10.6084/m9.figshare.6015047
title: Additional file 3: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: The taxonomy, co-abundance group and dynamics of the 50 key OTUs. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.6015047.v1
title: Additional file 3: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: The taxonomy, co-abundance group and dynamics of the 50 key OTUs. (XLSX 13Â kb)
DOI: 10.6084/m9.figshare.6015074
title: Additional file 5: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: Impact of calorie restriction on gut microbiota in the first 14Â days. a PerMANOVA test (9999 permutations) based on Bray-Curtis distances of samples. (XLSX 8Â kb)
DOI: 10.6084/m9.figshare.6015074.v1
title: Additional file 5: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: Impact of calorie restriction on gut microbiota in the first 14Â days. a PerMANOVA test (9999 permutations) based on Bray-Curtis distances of samples. (XLSX 8Â kb)
DOI: 10.6084/m9.figshare.6015104
title: Additional file 8: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: The 16S rRNA gene sequence similarity between the two strains of Lactobacillus spp. and their close relatives. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6015104.v1
title: Additional file 8: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: The 16S rRNA gene sequence similarity between the two strains of Lactobacillus spp. and their close relatives. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6015113
title: Additional file 9: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: ANI values between the two strains of Lactobacillus spp. and their phylogenetic relatives. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6015113.v1
title: Additional file 9: of Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

description: ANI values between the two strains of Lactobacillus spp. and their phylogenetic relatives. (XLSX 9Â kb)
DOI: 10.6084/m9.figshare.6020753
title: Additional file 1: of Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

description: Figure S1. Comparison of serum cytokines between AOSD and HC. Serum IL-1β (a), IL-1Rα (b), TNF-α (c), soluble tumor necrosis factor receptor (d), IL-6 (e), IL-18 (f), IL-17 (g), and IL-10 (h) protein levels among patients with AOSD with active and inactive disease activity (active [n = 41] versus inactive [n = 21]) as well as HC (n = 50) were determined by ELISA. Each symbol represents an individual patient with AOSD and an HC. Horizontal lines indicate median values. The data represent the mean ± SD. *** P &lt; 0.001 by Student’s t test. Figure S2. Comparison of serum IL-37 levels between patients with AOSD with different disease patterns. (a) The serum IL-37 levels in 59 patients with AOSD with a systemic course and 3 with an articular course. (b) The serum IL-37 levels in 39 patients with AOSD with a monophasic course, 20 with a polycyclic course and 3 with an articular course. Data are expressed as the mean ± SD. The Mann-Whitney U test was used to perform the statistical analysis. (ZIP 2677 kb)
DOI: 10.6084/m9.figshare.6020753.v1
title: Additional file 1: of Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

description: Figure S1. Comparison of serum cytokines between AOSD and HC. Serum IL-1β (a), IL-1Rα (b), TNF-α (c), soluble tumor necrosis factor receptor (d), IL-6 (e), IL-18 (f), IL-17 (g), and IL-10 (h) protein levels among patients with AOSD with active and inactive disease activity (active [n = 41] versus inactive [n = 21]) as well as HC (n = 50) were determined by ELISA. Each symbol represents an individual patient with AOSD and an HC. Horizontal lines indicate median values. The data represent the mean ± SD. *** P &lt; 0.001 by Student’s t test. Figure S2. Comparison of serum IL-37 levels between patients with AOSD with different disease patterns. (a) The serum IL-37 levels in 59 patients with AOSD with a systemic course and 3 with an articular course. (b) The serum IL-37 levels in 39 patients with AOSD with a monophasic course, 20 with a polycyclic course and 3 with an articular course. Data are expressed as the mean ± SD. The Mann-Whitney U test was used to perform the statistical analysis. (ZIP 2677 kb)
DOI: 10.6084/m9.figshare.6020810
title: Additional file 2: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S2. Effects of BRCA germline mutation and other prognostic factors (all covariates) on clinical end points by Cox proportional hazards analysis. The four clinical end points are: breast cancer (BC) recurrence or death, BC recurrence (locoregional or distant), distant recurrence, and death from any cause. Both univariate and multivariate analyses are shown. Statistically significant P-values (&lt;â 0.05) in the multivariate analyses are shown in bold. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.6020810.v1
title: Additional file 2: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S2. Effects of BRCA germline mutation and other prognostic factors (all covariates) on clinical end points by Cox proportional hazards analysis. The four clinical end points are: breast cancer (BC) recurrence or death, BC recurrence (locoregional or distant), distant recurrence, and death from any cause. Both univariate and multivariate analyses are shown. Statistically significant P-values (&lt;â 0.05) in the multivariate analyses are shown in bold. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.6020828
title: Additional file 5: of Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L.

description: Date S1. Significantly enriched GO terms of the DEGs. (XLSX 575Â kb)
DOI: 10.6084/m9.figshare.6020828.v1
title: Additional file 5: of Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L.

description: Date S1. Significantly enriched GO terms of the DEGs. (XLSX 575Â kb)
DOI: 10.6084/m9.figshare.6020831
title: Additional file 3: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S3. Correlation between clinical risk factors of hereditary breast cancer and having pathogenic germline mutations in different gene combinations: A. Correlation with all 20 genes; B. Correlation with BRCA1, BRCA2, PALB2, TP53 only; C. Correlation with BRCA1, BRCA2 only. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.6020831.v1
title: Additional file 3: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S3. Correlation between clinical risk factors of hereditary breast cancer and having pathogenic germline mutations in different gene combinations: A. Correlation with all 20 genes; B. Correlation with BRCA1, BRCA2, PALB2, TP53 only; C. Correlation with BRCA1, BRCA2 only. (XLSX 14Â kb)
DOI: 10.6084/m9.figshare.6020855
title: Additional file 4: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S1. Carriers of pathogenic mutations with their respective clinical risk factors for hereditary breast cancer, and ClinVar ( https://www.ncbi.nlm.nih.gov/clinvar/ ) accession numbers for novel pathogenic variants. (XLSX 15Â kb)
DOI: 10.6084/m9.figshare.6020855.v1
title: Additional file 4: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S1. Carriers of pathogenic mutations with their respective clinical risk factors for hereditary breast cancer, and ClinVar ( https://www.ncbi.nlm.nih.gov/clinvar/ ) accession numbers for novel pathogenic variants. (XLSX 15Â kb)
DOI: 10.6084/m9.figshare.6020879
title: Additional file 5: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S4. Clinical Dataset. Spreadsheet with code-book, containing pathogenic germline gene mutation, hereditary breast cancer risk factors, clinical characteristics, and outcomes in the cohort of breast cancer patients (Nâ =â 457). (XLSX 65Â kb)
DOI: 10.6084/m9.figshare.6020879.v1
title: Additional file 5: of Germline breast cancer susceptibility gene mutations and breast cancer outcomes

description: Table S4. Clinical Dataset. Spreadsheet with code-book, containing pathogenic germline gene mutation, hereditary breast cancer risk factors, clinical characteristics, and outcomes in the cohort of breast cancer patients (Nâ =â 457). (XLSX 65Â kb)
DOI: 10.6084/m9.figshare.6021083
title: Additional file 1: of High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production

description: 16S metadata and experiment raw data. (XLS 219Â kb)
DOI: 10.6084/m9.figshare.6021083.v1
title: Additional file 1: of High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production

description: 16S metadata and experiment raw data. (XLS 219Â kb)
DOI: 10.6084/m9.figshare.6021125
title: Additional file 3: of High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production

description: Nanostring raw counts. (XLS 108Â kb)
DOI: 10.6084/m9.figshare.6021125.v1
title: Additional file 3: of High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production

description: Nanostring raw counts. (XLS 108Â kb)
DOI: 10.6084/m9.figshare.6021140
title: Additional file 10: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: Conditional identified QTLs and consensus QTLs obtained for C18:0 in six environments. (XLS 52Â kb)
DOI: 10.6084/m9.figshare.6021140.v1
title: Additional file 10: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: Conditional identified QTLs and consensus QTLs obtained for C18:0 in six environments. (XLS 52Â kb)
DOI: 10.6084/m9.figshare.6021149
title: Additional file 11: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: QTL comparison between unconditional and conditional consensus QTLs for C18:0. (XLS 31Â kb)
DOI: 10.6084/m9.figshare.6021170
title: Additional file 12: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: Conditional identified QTLs and consensus QTLs obtained for C18:1 in six environments. (XLS 47Â kb)
DOI: 10.6084/m9.figshare.6021170.v1
title: Additional file 12: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: Conditional identified QTLs and consensus QTLs obtained for C18:1 in six environments. (XLS 47Â kb)
DOI: 10.6084/m9.figshare.6021185
title: Additional file 13: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: QTL comparison between unconditional and conditional consensus QTLs for C18:1. (XLS 32Â kb)
DOI: 10.6084/m9.figshare.6021185.v1
title: Additional file 13: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: QTL comparison between unconditional and conditional consensus QTLs for C18:1. (XLS 32Â kb)
DOI: 10.6084/m9.figshare.6021215
title: Additional file 14: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: Conditional identified QTLs and consensus QTLs obtained for C18:2 in six environments. (XLS 57Â kb)
DOI: 10.6084/m9.figshare.6021215.v1
title: Additional file 14: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: Conditional identified QTLs and consensus QTLs obtained for C18:2 in six environments. (XLS 57Â kb)
DOI: 10.6084/m9.figshare.6021227
title: Additional file 15: of Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.

description: QTL comparison between unconditional and conditional consensus QTLs for C18:2. (XLS 36Â kb)