DOI: 10.7270/q2dj5kb8
title: BindingDB Entry 50012623: Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.

description: Small molecule binding data for protein ALK tyrosine kinase receptor, Activated CDC42 kinase 1, Angiopoietin-1 receptor, Aurora kinase A, Aurora kinase B, Aurora kinase C, BDNF/NT-3 growth factors receptor, Beta-adrenergic receptor kinase 1, Beta-adrenergic receptor kinase 2, Bone morphogenetic protein receptor type-2, CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7, Calcium/calmodulin-dependent protein kinase kinase 1, Calcium/calmodulin-dependent protein kinase kinase 2, Calcium/calmodulin-dependent protein kinase type 1, Calcium/calmodulin-dependent protein kinase type 1B, Calcium/calmodulin-dependent protein kinase type 1D, Calcium/calmodulin-dependent protein kinase type 1G, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Calcium/calmodulin-dependent protein kinase type II subunit beta, Calcium/calmodulin-dependent protein kinase type II subunit delta, Calcium/calmodulin-dependent protein kinase type II subunit gamma, Calcium/calmodulin-dependent protein kinase type IV, Casein kinase I isoform alpha, Casein kinase I isoform alpha-like, Casein kinase I isoform gamma-1, Casein kinase I isoform gamma-2, Casein kinase I isoform gamma-3, Casein kinase II subunit alpha', Cell division cycle 7-related protein kinase/Protein DBF4 homolog A, Citron Rho-interacting kinase, Cyclin-A1/Cyclin-dependent kinase 2, Cyclin-A2/Cyclin-dependent kinase 2, Cyclin-K, Cyclin-O, Cyclin-T1/Cyclin-dependent kinase 9, Cyclin-Y/Cyclin-dependent kinase 16, Cyclin-Y/Cyclin-dependent kinase 17, Cyclin-dependent kinase 18, Cyclin-dependent kinase 2/G1/S-specific cyclin-E1, Cyclin-dependent kinase 3/G1/S-specific cyclin-E1, Cyclin-dependent kinase 4/G1/S-specific cyclin-D3, Cyclin-dependent kinase 5 activator 1, Cyclin-dependent kinase 6/G1/S-specific cyclin-D1, Cyclin-dependent kinase 6/G1/S-specific cyclin-D3, Cyclin-dependent kinase/G1/S-specific cyclin- 1, Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, Cytoplasmic tyrosine-protein kinase BMX, Death-associated protein kinase 1, Death-associated protein kinase 2, Death-associated protein kinase 3, Discoidin domain-containing receptor 2, Dual serine/threonine and tyrosine protein kinase, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity mitogen-activated protein kinase kinase 5, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 7, Dual specificity protein kinase CLK1, Dual specificity protein kinase CLK2, Dual specificity protein kinase CLK3, Dual specificity protein kinase CLK4, Dual specificity testis-specific protein kinase 1, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dual specificity tyrosine-phosphorylation-regulated kinase 2, Dual specificity tyrosine-phosphorylation-regulated kinase 3, Ephrin type-A receptor 1, Ephrin type-A receptor 2, Ephrin type-A receptor 3, Ephrin type-A receptor 4, Ephrin type-A receptor 5, Ephrin type-A receptor 6, Ephrin type-A receptor 7, Ephrin type-A receptor 8, Ephrin type-B receptor 1, Ephrin type-B receptor 2, Ephrin type-B receptor 3, Ephrin type-B receptor 4, Epidermal growth factor receptor, Epithelial discoidin domain-containing receptor 1, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1, G protein-coupled receptor kinase 4, G protein-coupled receptor kinase 5, G protein-coupled receptor kinase 6, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, Hepatocyte growth factor receptor, Hexokinase-4, High affinity nerve growth factor receptor, Homeodomain-interacting protein kinase 2, Homeodomain-interacting protein kinase 3, Homeodomain-interacting protein kinase 4, Inactive tyrosine-protein kinase PEAK1, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Inhibitor of nuclear factor kappa-B kinase subunit beta, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Insulin receptor, Insulin receptor-related protein, Insulin-like growth factor 1 receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, Kinase suppressor of Ras 1, Kinase suppressor of Ras 2, LIM domain kinase 1, LIM domain kinase 2, Leucine-rich repeat serine/threonine-protein kinase 2, Leukocyte tyrosine kinase receptor, Lymphokine-activated killer T-cell-originated protein kinase, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 3, MAP kinase-activated protein kinase 5, MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase-interacting serine/threonine-protein kinase 2, MAP/microtubule affinity-regulating kinase 3, MAP/microtubule affinity-regulating kinase 4, Macrophage colony-stimulating factor 1 receptor, Macrophage-stimulating protein receptor, Mast/stem cell growth factor receptor Kit, Maternal embryonic leucine zipper kinase, Megakaryocyte-associated tyrosine-protein kinase, Misshapen-like kinase 1, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 12, Mitogen-activated protein kinase 13, Mitogen-activated protein kinase 15, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 7, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase 10, Mitogen-activated protein kinase kinase kinase 11, Mitogen-activated protein kinase kinase kinase 12, Mitogen-activated protein kinase kinase kinase 19, Mitogen-activated protein kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase 21, Mitogen-activated protein kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase 5, Mitogen-activated protein kinase kinase kinase 6, Mitogen-activated protein kinase kinase kinase 7, Mitogen-activated protein kinase kinase kinase 9, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Muscle, skeletal receptor tyrosine-protein kinase, Myosin light chain kinase 2, skeletal/cardiac muscle, Myosin light chain kinase 3, Myosin light chain kinase family member 4, Myosin light chain kinase, smooth muscle, Myosin-IIIa, Myosin-IIIb, Myotonin-protein kinase, NT-3 growth factor receptor, NUAK family SNF1-like kinase 1, NUAK family SNF1-like kinase 2, Non-receptor tyrosine-protein kinase TNK1, Non-receptor tyrosine-protein kinase TYK2, PAS domain-containing serine/threonine-protein kinase, Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor beta, Protein kinase C alpha type, Protein kinase C beta type, Protein kinase C delta type, Protein kinase C epsilon type, Protein kinase C eta type, Protein kinase C gamma type, Protein kinase C iota type, Protein kinase C theta type, Protein kinase C zeta type, Protein odd-skipped-related 1, Protein-tyrosine kinase 2-beta, Protein-tyrosine kinase 6, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret, RAC-alpha serine/threonine-protein kinase, RAC-beta serine/threonine-protein kinase, RAC-gamma serine/threonine-protein kinase, Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-4, Receptor-interacting serine/threonine-protein kinase 2, Receptor-type tyrosine-protein kinase FLT3, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rhodopsin kinase GRK1, Rhodopsin kinase GRK7, Ribosomal protein S6 kinase alpha-1, Ribosomal protein S6 kinase alpha-2, Ribosomal protein S6 kinase alpha-3, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Ribosomal protein S6 kinase alpha-6, Ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase beta-2, SNF-related serine/threonine-protein kinase, SRSF protein kinase 1, SRSF protein kinase 2, SRSF protein kinase 3, STE20-like serine/threonine-protein kinase, STE20/SPS1-related proline-alanine-rich protein kinase, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 16, Serine/threonine-protein kinase 17A, Serine/threonine-protein kinase 24, Serine/threonine-protein kinase 25, Serine/threonine-protein kinase 26, Serine/threonine-protein kinase 3, Serine/threonine-protein kinase 32B, Serine/threonine-protein kinase 32C, Serine/threonine-protein kinase 33, Serine/threonine-protein kinase 38, Serine/threonine-protein kinase 38-like, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase BRSK1, Serine/threonine-protein kinase BRSK2, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2, Serine/threonine-protein kinase D3, Serine/threonine-protein kinase DCLK1, Serine/threonine-protein kinase DCLK2, Serine/threonine-protein kinase ICK, Serine/threonine-protein kinase LATS1, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase MAK, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MARK2, Serine/threonine-protein kinase MRCK alpha, Serine/threonine-protein kinase MRCK beta, Serine/threonine-protein kinase MRCK gamma, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase N2, Serine/threonine-protein kinase N3, Serine/threonine-protein kinase NIM1, Serine/threonine-protein kinase NLK, Serine/threonine-protein kinase Nek1, Serine/threonine-protein kinase Nek11, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase Nek3, Serine/threonine-protein kinase Nek4, Serine/threonine-protein kinase Nek5, Serine/threonine-protein kinase Nek8, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 1, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase PAK 3, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 5, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase PLK2, Serine/threonine-protein kinase PLK3, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SBK1, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase STK11, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase Sgk2 [61-427], Serine/threonine-protein kinase Sgk3, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase TAO3, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase ULK2, Serine/threonine-protein kinase ULK3, Serine/threonine-protein kinase WNK1, Serine/threonine-protein kinase WNK2, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Serine/threonine-protein kinase pim-3, Serine/threonine-protein kinase tousled-like 1, Serine/threonine-protein kinase tousled-like 2, Serine/threonine-protein kinase/endoribonuclease IRE1, Serine/threonine-protein kinase/endoribonuclease IRE2, TRAF2 and NCK-interacting protein kinase, Testis-specific serine/threonine-protein kinase 1, Testis-specific serine/threonine-protein kinase 2, Testis-specific serine/threonine-protein kinase 3, Testis-specific serine/threonine-protein kinase 6, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase ABL2, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase FRK, Tyrosine-protein kinase Fer, Tyrosine-protein kinase Fes/Fps, Tyrosine-protein kinase Fgr, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Mer, Tyrosine-protein kinase SYK, Tyrosine-protein kinase Srms, Tyrosine-protein kinase TXK, Tyrosine-protein kinase Tec, Tyrosine-protein kinase Yes, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase receptor UFO, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, cAMP-dependent protein kinase catalytic subunit PRKX, cAMP-dependent protein kinase catalytic subunit beta, cAMP-dependent protein kinase catalytic subunit gamma, cGMP-dependent protein kinase 1, and cGMP-dependent protein kinase 2, Uniprot O00141, O00311, O00444, O00506, O14578, O14733, O14757, O14920, O14965, O15075, O15111, O15146, O15264, O43293, O43318, O43353, O43781, O60285, O60563, O60674, O75116, O75385, O75460, O75582, O75676, O75716, O75909, O75914, O94804, O94806, O95382, O95819, O95835, O96013, O96017, P00519, P00533, P04626, P04629, P05129, P05177, P05771, P06213, P06239, P06241, P06493, P07332, P07333, P07947, P07948, P07949, P08069, P08581, P08631, P08684, P08922, P09619, P09769, P10635, P10721, P11309, P11362, P11712, P11802, P12931, P14616, P14635, P15735, P16234, P16591, P17252, P17948, P19784, P20248, P20794, P21709, P21802, P22455, P22607, P22612, P22674, P22694, P23443, P23458, P24385, P24723, P24864, P24941, P25098, P27361, P27448, P28482, P29317, P29320, P29322, P29323, P29376, P29597, P30281, P30530, P31749, P31751, P32298, P33261, P34947, P35557, P35626, P35916, P35968, P36507, P36888, P41240, P41743, P42679, P42680, P42681, P42684, P42685, P43250, P43403, P43405, P45983, P45984, P45985, P46734, P48729, P49137, P49759, P49760, P49761, P49840, P49841, P50613, P50750, P51451, P51617, P51812, P51813, P51817, P51946, P51948, P51955, P51956, P51957, P52333, P52564, P53350, P53355, P53667, P53671, P53778, P54753, P54756, P54760, P54762, P54764, P57059, P78362, P78368, P78396, P80192, Q00526, Q00534, Q00535, Q00536, Q00537, Q02156, Q02750, Q02763, Q02779, Q04759, Q04912, Q05397, Q05513, Q05655, Q06187, Q06418, Q07002, Q07912, Q08345, Q08881, Q09013, Q12852, Q12866, Q13043, Q13153, Q13163, Q13164, Q13177, Q13188, Q13233, Q13237, Q13464, Q13470, Q13554, Q13555, Q13557, Q13627, Q13873, Q13882, Q13976, Q14012, Q14164, Q14289, Q14680, Q15078, Q15118, Q15139, Q15208, Q15303, Q15349, Q15375, Q15418, Q15569, Q15746, Q15831, Q15835, Q16288, Q16512, Q16513, Q16566, Q16584, Q16620, Q16644, Q16816, Q16832, Q32MK0, Q52WX2, Q56UN5, Q5S007, Q5TCX8, Q5VT25, Q6DT37, Q6P2M8, Q6P3R8, Q6P5Z2, Q6PHR2, Q6VAB6, Q6XUX3, Q76MJ5, Q7KZI7, Q7L7X3, Q86SG6, Q86UE8, Q86UX6, Q86V86, Q86YV6, Q8IU85, Q8IVH8, Q8IVT5, Q8IW41, Q8IWQ3, Q8IY84, Q8IYT8, Q8N4C8, Q8N568, Q8N5S9, Q8N752, Q8ND76, Q8NE63, Q8NEV4, Q8NG66, Q8TAX0, Q8TD08, Q8TD19, Q8TDC3, Q8TF76, Q8WTQ7, Q8WXR4, Q92630, Q96BR1, Q96GD4, Q96KB5, Q96L34, Q96NX5, Q96PF2, Q96PN8, Q96PY6, Q96RG2, Q96RR4, Q96SB4, Q99683, Q99759, Q9BUB5, Q9BXA6, Q9BXA7, Q9BYT3, Q9BZL6, Q9H093, Q9H0K1, Q9H1R3, Q9H2G2, Q9H2K8, Q9H2X6, Q9H3Y6, Q9H422, Q9H4A3, Q9H4B4, Q9H792, Q9HAZ1, Q9HBH9, Q9HBY8, Q9HCP0, Q9NQU5, Q9NRH2, Q9NRM7, Q9NWZ3, Q9NY57, Q9NYY3, Q9P0L2, Q9P1W9, Q9P286, Q9P289, Q9UBE8, Q9UBS0, Q9UBU7, Q9UEE5, Q9UEW8, Q9UF33, Q9UHD2, Q9UIK4, Q9UK32, Q9UKE5, Q9UKI8, Q9UL54, Q9UM73, Q9UPE1, Q9UPZ9, Q9UQB9, Q9UQM7, Q9Y243, Q9Y2H1, Q9Y2K2, Q9Y2U5, Q9Y3S1, Q9Y463, Q9Y4K4, Q9Y5S2, Q9Y6E0, and Q9Y6M4