cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.25402/bio.21299499.v1
title: Application of a new volumetric microsampling device for quantitative bioanalysis of immunosuppression: Supplementary material

description: Background: Volumetric absorptive microsampling may reduce the blood collection burden associated
with therapeutic drug monitoring of immunosuppression to prevent organ transplant rejection. This
work describes the development of a laboratory and analytical technique for quantifying tacrolimus and
mycophenolic acid (MPA) from the Tasso-M20™ in human whole blood using bead-based impact-assisted
extraction. Results: The sampled blood volume was accurate with estimated volumes within &lt;2% of the
expected 20 μl. Recovery using impact-assisted extraction was 73–87% for MPA and 100% for tacrolimus
and was hematocrit-independent for both analytes. The LC-MS/MS assay is precise and accurate within
the acceptance criteria of 15%. Conclusion: The sampling and extraction procedures allowed for accurate
quantification of tacrolimus and MPA. Exploration of abuse scenarios identified important education
points for patients conducting home-based sample collections in the future.
DOI: 10.25402/bio.21684851
title: Development and validation of an LC–MS/MS method to quantify kynurenic acid in human plasma: supplementary data

description: Background: Monitoring levels of endogenous biomarkers has become an alternative approach to
assess transporter-mediated drug–drug interactions in clinical trials. Among the biomarkers of interest,
kynurenic acid is effective for the human organic anion transporters OAT1 and OAT3. Here, a simple
and robust bioanalytical method was developed using LC–MS/MS to quantify kynurenic acid in human
plasma. Results: This method achieved a LLOQ of 10 nm with acceptable signal-to-noise ratio (S/N &gt;5).
In addition, an interfering agent, tryptophan, was identified and separated chromatographically. A full
method validation was performed in the spirit of GLP. Conclusion: This method can serve as a tool readily
available to assess potential drug–drug interactions mediated by inhibition of OAT1 and OAT3 activities.
DOI: 10.25402/bio.21915408.v1
title: Bioanalysis of tucatinib and metabolite, and a five-way cross-validation to support clinical pharmacokinetic analysis: Supplementary data

description: Tucatinib, a tyrosine kinase inhibitor of HER2, is approved in multiple regions for metastatic breast
cancer and is being evaluated in metastatic colorectal and gastric cancers. During clinical development,
quantification of tucatinib plasma concentrations for pharmacokinetic analysis was performed using
MS/MS analysis by three laboratories using five different methods. Cross-validation was required to
confirm data across laboratories were comparable. A five-way cross-validation procedure was developed
where bioanalysis performed by one laboratory and method was used as a ‘base’ against which the other
methods were validated. This cross-validation method provides an alternative to multiple head-to-head
comparisons between two methods, and enabled combination of data from multiple tucatinib clinical
trials for a single population pharmacokinetic analysis.
DOI: 10.25402/bio.21684851.v1
title: Development and validation of an LC–MS/MS method to quantify kynurenic acid in human plasma: supplementary data

description: Background: Monitoring levels of endogenous biomarkers has become an alternative approach to
assess transporter-mediated drug–drug interactions in clinical trials. Among the biomarkers of interest,
kynurenic acid is effective for the human organic anion transporters OAT1 and OAT3. Here, a simple
and robust bioanalytical method was developed using LC–MS/MS to quantify kynurenic acid in human
plasma. Results: This method achieved a LLOQ of 10 nm with acceptable signal-to-noise ratio (S/N &gt;5).
In addition, an interfering agent, tryptophan, was identified and separated chromatographically. A full
method validation was performed in the spirit of GLP. Conclusion: This method can serve as a tool readily
available to assess potential drug–drug interactions mediated by inhibition of OAT1 and OAT3 activities.
DOI: 10.25402/bio.22332799
title: Multi-laboratory evaluation of immunoaffinity LC–MS-based glucagon-like peptide-1 assay: Supplementary data

description: Background: Although the fit-for-purpose approach has been proposed for biomarker assay validation,
practical data should be compiled to facilitate the predetermination of acceptance criteria. Methods:
Immunoaffinity LC–MS was used to analyze glucagon-like peptide-1 as a model biomarker in six
laboratories. Calibration curve, carryover, parallelism, precision, relative accuracy and processed sample
stability were evaluated, and their robustness among laboratories was assessed. The rat glucagon-like
peptide-1 concentrations in four blinded samples were also compared. Results: The obtained results and
determined concentrations in the blinded samples at all laboratories were similar, with a few exceptions,
and robust, despite the difference in optimization techniques among laboratories. Conclusion: The
results provide insights into the predefinition of the acceptance criteria of immunoaffinity LC–MS-based
biomarker assays.
DOI: 10.15468/dl.rkedxw
title: Occurrence Download

description: A dataset containing 7702 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is United States of America",
 "DatasetKey is iNaturalist Research-grade Observations",
 "TaxonKey is Asclepias speciosa Torr.",
 "Year 2020-2024"
 ]
}

 The dataset includes 7702 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020860-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.25402/bio.22726262.v1
title: Development of Fe3O4/reduced graphene oxide nanocomposite-based dispersive solid-phase extraction for the quantification of five steroid hormones: supplementary materials

description: Aim: An accurate and sensitive analytical method was proposed to detect some steroid hormones
in biological samples. Materials & methods: An Fe3O4/reduced graphene oxide nanocomposite-based
dispersive solid-phase extraction was developed for the effective and simple preconcentration of steroid
hormones from human serum samples. Results & conclusion: The nanocomposite was firstly used as
adsorbent to simultaneously extract the selected hormones. Limit of detection values for the selected
hormones were calculated between 5.5 and 39.2 ng/kg (mass based). An artificial serum sample was used
to test the applicability and accuracy of the developedmethod; percentage recovery results obtained from
two different spiked concentrations were found to be in the range of 80.5–99.9%.
DOI: 10.25402/bio.22726280.v1
title: Stability of nonsteroidal anti-inflammatory drugs in urine and solution: effects of degradation on analytical assessment: supplementary materials

description: Aims: Knowledge of optimal storage conditions of drugs is crucial for properly interpreting analytical
assessments. Materials & methods: The current study aimed to investigate the stability of some
nonsteroidal anti-inflammatory drugs using a validated method by gas chromatography (GC)–MS. For this
propose, long-term, short-term and solution stability were investigated. Results: The analytes remained
stable in the sample, similar to the working solution. The most affected substance over time in both
matrix and working solution was phenylbutazone. The freeze–thaw cycle affected flunixin and carprofen,
but diclofenac and vedaprofen changed only in the third cycle. In short-term stability, high-temperature
conditions changed carprofen. Conclusion: The present study is a comprehensive assay for nonsteroidal
anti-inflammatory drug stability and can be used as a reference for results assessment.
DOI: 10.15468/dl.7jw7ye
title: Occurrence Download

description: A dataset containing 278698 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is one of (Ulmus minor Mill.)"
 ]
}

 The dataset includes 278698 records from 2351 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0020858-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qxgs9e
title: Occurrence Download

description: A dataset containing 2841 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Delphinium glaucum S.Watson"
 ]
}

 The dataset includes 2841 records from 117 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0165120-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.so8hyb
title: Occurrence Download

description: A dataset containing 840 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Perumytilus purpuratus (Lamarck, 1819)"
 ]
}

 The dataset includes 840 records from 37 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013801-181108115102211/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.krwvwn
title: Occurrence Download

description: A dataset containing 15284 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Anolis carolinensis Voigt, 1832"
 ]
}

 The dataset includes 15284 records from 79 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-160822134323880/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.rspzn5
title: Occurrence Download

description: A dataset containing 16004 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cissus verticillata (L.) Nicolson & C.E.Jarvis"
 ]
}

 The dataset includes 16004 records from 415 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012442-240202131308920/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qq9ew0
title: Occurrence Download

description: A dataset containing 2340 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Cookeina Kuntze"
 ]
}

 The dataset includes 2340 records from 80 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030360-190918142434337/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4uq7i1
title: Occurrence Download

description: A dataset containing 10 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Elaeis guineensis Jacq.",
 "Country is Colombia",
 "Geometry POLYGON((-180 -82,-180 82,180 82,180 -82,-180 -82))"
 ]
}

 The dataset includes 10 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150316153013904/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jnnark
title: Occurrence Download

description: A dataset containing 16708 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is BIOMASS 1980-1985"
 ]
}

 The dataset includes 16708 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000973-240216155721649/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c3s6sn
title: Occurrence Download

description: A dataset listing the 124 species recorded in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Chinese Taipei)",
 "TaxonKey is Hymenophyllum J.E.Sm."
 ]
}

 The dataset's 124 records were derived from 61 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0025400-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6anmnq
title: Occurrence Download

description: A dataset containing 818 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Trigona hyalinata (Lepeletier, 1836)"
 ]
}

 The dataset includes 818 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150410134957023/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ajfejb
title: Occurrence Download

description: A dataset containing 823 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Argentina",
 "TaxonKey is Solanum argentinum Bitter & Lillo"
 ]
}

 The dataset includes 823 records from 42 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0165117-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bhw2yd
title: Occurrence Download

description: A dataset containing 13929 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Phanerogamic Botanical Collections (S)",
 "Country is Australia"
 ]
}

 The dataset includes 13929 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0328381-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.fjjlvb
title: Occurrence Download

description: A dataset containing 248 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sorex veraepacis Alston, 1877",
 "HasGeospatialIssue is false",
 "HasCoordinate is true"
 ]
}

 The dataset includes 248 records from 19 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150504100648427/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wcawhq
title: Occurrence Download

description: A dataset containing 160 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Botryosphaeria dothidea (Moug.) Ces. & De Not."
 ]
}

 The dataset includes 160 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0165089-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xbqja3
title: Occurrence Download

description: A dataset containing 13555 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is Malacology Collection at the Academy of Natural Sciences of Philadelphia",
 "Country is Australia"
 ]
}

 The dataset includes 13555 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0328367-200613084148143/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pbpuf5
title: Occurrence Download

description: A dataset containing 1550029 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Arthropoda",
 "Country is Austria"
 ]
}

 The dataset includes 1550029 records from 199 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150512124619364/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.qvzzjc
title: Occurrence Download

description: A dataset containing 329957 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Human Observation, Occurrence evidence, Living Specimen, Observation, Material citation, Machine Observation)",
 "Continent is one of (North America, South America)",
 "TaxonKey is Elasmobranchii"
 ]
}

 The dataset includes 329957 records from 299 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0165095-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xa8pby
title: Occurrence Download

description: A dataset containing 58 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Cuniculidae",
 "Country is Brazil"
 ]
}

 The dataset includes 58 records from 9 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150615163101818/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.gbca9b
title: Occurrence Download

description: A dataset containing 38 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Ponthieva pauciflora (Sw.) Fawc. & Rendle"
 ]
}

 The dataset includes 38 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0188284-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xekw6g
title: Occurrence Download

description: A dataset containing 22 species occurrences available in GBIF matching the query:
{
 "and" : [
 "GadmGid is COD",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Mondia whitei (Hook.fil.) Skeels"
 ]
}

 The dataset includes 22 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009361-230828120925497/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.h4qsjt
title: Occurrence Download

description: A dataset containing 165 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Hipposideros vittatus (Peters, 1852)"
 ]
}

 The dataset includes 165 records from 11 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150912100344238/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hhv3us
title: Occurrence Download

description: A dataset containing 135326 species occurrences available in GBIF matching the query:
{
 "DatasetKey" : [
 "is Natural History Museum Rotterdam - Observations"
 ]
}

 The dataset includes 135326 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030363-190918142434337/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.vt7u38
title: Occurrence Download

description: A dataset containing 239 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Delphinium geraniifolium Rydb."
 ]
}

 The dataset includes 239 records from 31 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0165097-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ffh1fh
title: Occurrence Download

description: A dataset containing 6618 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Spain",
 {
 "or" : [
 "TaxonKey is Sorbus aria (L.) Crantz",
 {
 "and" : [
 "TaxonKey is Sventenia bupleuroides Font Quer",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 {
 "and" : [
 "TaxonKey is Teline pallida subsp. pallida",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 "TaxonKey is Teline pallida subsp. gomerae (P.E.Gibbs & Dingwall) M.del Arco Aguilar",
 "TaxonKey is Teline rosmarinifolia",
 {
 "and" : [
 "TaxonKey is Tolpis crassiuscula Svent.",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 {
 "and" : [
 "TaxonKey is Viola anagae Gilli",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 "TaxonKey is Withania frutescens (L.) Pauquy",
 {
 "and" : [
 "TaxonKey is Asplenium terorense G.Kunkel",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 "TaxonKey is Asteriscus schultzii (Bolle) Pit. & Proust",
 "TaxonKey is Bystropogon wildpretii La Serna",
 "TaxonKey is Echium triste Svent.",
 "TaxonKey is Herniaria canariensis Chaudhri",
 {
 "and" : [
 "TaxonKey is Mesembryanthemum theurkauffii (Maire) Maire",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 "TaxonKey is Plantago asphodeloides Svent.",
 "TaxonKey is Pulicaria canariensis Bolle",
 "TaxonKey is Sarcocornia perennis (Mill.) A.J.Scott",
 "TaxonKey is Vicia filicaulis Webb & Berthel.",
 "TaxonKey is Vicia nataliae U.Reifenb. & A.Reifenb.",
 {
 "and" : [
 "TaxonKey is Delphinium pentagynum subsp. formenteranum N.Torres, L.Sáez, Rosselló & C.Blanché",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 "TaxonKey is Biscutella ebusitana Rosselló, N.Torres & L.Sáez",
 "TaxonKey is Thapsia garganica L.",
 {
 "and" : [
 "TaxonKey is Agrostis barceloi L.Sáez & Rosselló",
 "LastInterpreted is greater than 2015-04-16"
 ]
 },
 "TaxonKey is Helianthemum marifolium subsp. origanifolium (Lam.) G.López",
 "TaxonKey is Ligusticum huteri Porta"
 ]
 }
 ]
}

 The dataset includes 6618 records from 77 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0001273-150922153815467/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.o3rc7b
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "ScientificName is Rana_temporaria",
 "HasCoordinate is TRUE"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0030368-190918142434337/datasets/export for details.
DOI: 10.15468/dl.bum2xn
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Restrepia seketii Luer & R.Escobar"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0188288-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.hj9uhw
title: Occurrence Download

description: A dataset listing the 99 species recorded in GBIF matching the query:
{
 "and" : [
 "DatasetKey is iNaturalist Research-grade Observations",
 "Geometry POLYGON((-126.45352 46.78848,-121.00444 46.78848,-121.00444 50.67585,-126.45352 50.67585,-126.45352 46.78848))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "TaxonKey is Nudibranchia"
 ]
}

 The dataset's 99 records were derived from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006678-230918134249559/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.dfyyke
title: Occurrence Download

description: A dataset containing 1 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Platystele sancristobalensis Archila"
 ]
}

 The dataset includes 1 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0188289-240321170329656/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.