cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.5693410
title: MS data for Huang et al. NCB paper

description: To identify cofactors of IGF2BPs, we ectopically expressed FLAG-IGF2BP2 in HEK293T cells, pulled down the IGF2BP2 complexes using FLAG antibody and conducted mass spectrometry analysis. Immunoprecipitaion with IgG control and the subsequent mass spectrometry analysis were perform in parallel as a negative control. Proteins identified with 4 or more unique peptides each at 99% confidence are listed in the "Processed data.xlsx" file.
DOI: 10.6084/m9.figshare.5693290
title: Leishmania guyanensis LgCL085 genome FASTA file

description: Leishmania guyanensis LgCL085 genome FASTA file
DOI: 10.6084/m9.figshare.5693284
title: Leishmania guyanensis LgCL085 genome annotation files

description: Leishmania guyanensis LgCL085 genome annotation files
DOI: 10.6084/m9.figshare.5693284.v1
title: Leishmania guyanensis LgCL085 genome annotation files

description: Leishmania guyanensis LgCL085 genome annotation files
DOI: 10.6084/m9.figshare.5693278
title: Leishmania naiffi LnCL223 genome annotation files

description: Leishmania naiffi LnCL223 genome annotation files
DOI: 10.6084/m9.figshare.5693278.v1
title: Leishmania naiffi LnCL223 genome annotation files

description: Leishmania naiffi LnCL223 genome annotation files
DOI: 10.6084/m9.figshare.5693272
title: Leishmania naiffi LnCL223 genome FASTA file

description: Leishmania naiffi LnCL223 genome FASTA file
DOI: 10.6084/m9.figshare.5693272.v1
title: Leishmania naiffi LnCL223 genome FASTA file

description: Leishmania naiffi LnCL223 genome FASTA file
DOI: 10.6084/m9.figshare.5693254
title: Flood risk assessment using multi-criteria analysis: a case study from Kopili River Basin, Assam, India

description: A multi-criteria analysis (MCA) approach to describe the effective utilization of geospatial techniques for disaster risk reduction at village level in Kopili River Basin (KRB) of Assam State, India is presented. The KRB is chronically flood affected due to seasonal monsoon and rise in water levels of Kopili River. Based on the MCA approach using flood hazard layer derived from the spatio-multi-temporal historic satellite data-sets (comprising of sensors from RISAT-1 SAR, Radarsat SAR and IRS AWiFS), socio-economic data (based on five census variables), infrastructure (road network) and land use vulnerabilities (cropped and uncropped areas), flood risk zones are derived. Our study elucidates that 24,837 ha of crop area spread across 95 villages in the KRB falls in high risk zone, about 39,209 ha distributed in 150 villages falls under moderate-high risk zones and remaining area spread over 162 villages is more or less unaffected. The proposed approach can be applied elsewhere in other river basins to estimate the flood risk so as to mitigate the disaster risk posed by the floods.
DOI: 10.6084/m9.figshare.5693254.v1
title: Flood risk assessment using multi-criteria analysis: a case study from Kopili River Basin, Assam, India

description: A multi-criteria analysis (MCA) approach to describe the effective utilization of geospatial techniques for disaster risk reduction at village level in Kopili River Basin (KRB) of Assam State, India is presented. The KRB is chronically flood affected due to seasonal monsoon and rise in water levels of Kopili River. Based on the MCA approach using flood hazard layer derived from the spatio-multi-temporal historic satellite data-sets (comprising of sensors from RISAT-1 SAR, Radarsat SAR and IRS AWiFS), socio-economic data (based on five census variables), infrastructure (road network) and land use vulnerabilities (cropped and uncropped areas), flood risk zones are derived. Our study elucidates that 24,837 ha of crop area spread across 95 villages in the KRB falls in high risk zone, about 39,209 ha distributed in 150 villages falls under moderate-high risk zones and remaining area spread over 162 villages is more or less unaffected. The proposed approach can be applied elsewhere in other river basins to estimate the flood risk so as to mitigate the disaster risk posed by the floods.
DOI: 10.6084/m9.figshare.5693200
title: N-cadherin knockdown leads to disruption of trophoblastic and endothelial cell interaction in a 3D cell culture model – New insights in trophoblast invasion failure

description: <i>Introduction</i>: Trophoblast homing to maternal spiral arteries is mandatory for successful placentation. Cell-cell adhesion molecules regulate this process and adhesion molecule expression is altered in impaired placentation. We hypothesize that, similar to immune cell recruitment, trophoblast cell adherence and rolling are primarily mediated by adhesion molecules like, cadherins, immunoglobulins, selectins and their partnering ligands. Here, the interdependence of adhesion molecule expression in trophoblastic cell lines of diverse origin was investigated in relation to their interaction with endothelial cell networks on Matrigel® co-cultures and the effect of specific adhesion molecule knockdown analyzed. <i>Methods</i>: Trophoblastic cells were labeled in red and co-cultured with green HUVEC networks on Matrigel®. Association was quantified after collection of fluorescence microscopy pictures using Wimasis® internet platform and software. Expression of adhesion molecules was analyzed by PCR and Western blot, immuno-fluorescence and flow cytometry. The impact of adhesion molecules on trophoblast-endothelial-cell interaction was investigated using siRNA technique. <i>Results</i>: N-cadherin and CD162 were specifically expressed in the trophoblast cell line HTR-8/SVneo, which closely adhere to and actively migrate toward HUVEC networks on Matrigel®. Suppression of N-cadherin led to a significant alteration in trophoblast-endothelial cell interaction. Expression of VE-cadherin in closely interacting trophoblast cells was not confirmed <i>in vitro. Discussion</i>: We identified N-cadherin to mediate specific interaction between HUVEC and the migrating trophoblast cells HTR-8/SVneo in a Matrigel® co-culture model. VE-cadherin contribution could not be confirmed <i>in vitro</i>. Our results support the hypothesis that impaired N-cadherin but not VE-cadherin expression is involved in trophoblast recruitment to the maternal endothelium.
DOI: 10.6084/m9.figshare.5693200.v1
title: N-cadherin knockdown leads to disruption of trophoblastic and endothelial cell interaction in a 3D cell culture model – New insights in trophoblast invasion failure

description: <i>Introduction</i>: Trophoblast homing to maternal spiral arteries is mandatory for successful placentation. Cell-cell adhesion molecules regulate this process and adhesion molecule expression is altered in impaired placentation. We hypothesize that, similar to immune cell recruitment, trophoblast cell adherence and rolling are primarily mediated by adhesion molecules like, cadherins, immunoglobulins, selectins and their partnering ligands. Here, the interdependence of adhesion molecule expression in trophoblastic cell lines of diverse origin was investigated in relation to their interaction with endothelial cell networks on Matrigel® co-cultures and the effect of specific adhesion molecule knockdown analyzed. <i>Methods</i>: Trophoblastic cells were labeled in red and co-cultured with green HUVEC networks on Matrigel®. Association was quantified after collection of fluorescence microscopy pictures using Wimasis® internet platform and software. Expression of adhesion molecules was analyzed by PCR and Western blot, immuno-fluorescence and flow cytometry. The impact of adhesion molecules on trophoblast-endothelial-cell interaction was investigated using siRNA technique. <i>Results</i>: N-cadherin and CD162 were specifically expressed in the trophoblast cell line HTR-8/SVneo, which closely adhere to and actively migrate toward HUVEC networks on Matrigel®. Suppression of N-cadherin led to a significant alteration in trophoblast-endothelial cell interaction. Expression of VE-cadherin in closely interacting trophoblast cells was not confirmed <i>in vitro. Discussion</i>: We identified N-cadherin to mediate specific interaction between HUVEC and the migrating trophoblast cells HTR-8/SVneo in a Matrigel® co-culture model. VE-cadherin contribution could not be confirmed <i>in vitro</i>. Our results support the hypothesis that impaired N-cadherin but not VE-cadherin expression is involved in trophoblast recruitment to the maternal endothelium.
DOI: 10.6084/m9.figshare.5693182
title: The IMLS National Digital Platform: Principles, Librarianship, and Digital Infrastructures

description: Fall 2017 CNI presentation, Washington DC.Based on soon-to-be-released ACRL Book Chapter:ACRL BOOK: Applying Library Values to Emerging Technology: Tips and Techniques for Advancing within Your Mission BOOK CHAPTER: Digital Infrastructures that Embody Library Principles: The IMLS national digital platform as a framework for digital library tools and services BOOK CHAPTER AUTHORS: Trevor Owens, Ashley E. Sands, Emily Reynolds, James Neal, Stephen Mayeaux, Maura Marx
DOI: 10.6084/m9.figshare.5693182.v2
title: The IMLS National Digital Platform: Principles, Librarianship, and Digital Infrastructures

description: Fall 2017 CNI presentation, Washington DC.Based on soon-to-be-released ACRL Book Chapter:ACRL BOOK: Applying Library Values to Emerging Technology: Tips and Techniques for Advancing within Your Mission BOOK CHAPTER: Digital Infrastructures that Embody Library Principles: The IMLS national digital platform as a framework for digital library tools and services BOOK CHAPTER AUTHORS: Trevor Owens, Ashley E. Sands, Emily Reynolds, James Neal, Stephen Mayeaux, Maura Marx
DOI: 10.6084/m9.figshare.5693107.v1
title: Senegal_medical_CT_complete_nest.raw

description: The raw file contains 3D X-ray tomographic image of a termite nest constructed by <i>Trinervitermes trinervoides</i> termites. The nest was collected from Nguekokh, Senegal during early October 2010. The nest was in Savanna type vegetation, and was exposed to the sun.<br>The file size is 512, 512 and 369 pixels, with pixel size 0.55, 0.55 and 0.6 mm in X, Y and Z direction respectively. The file format is 8-bit .raw, and can be loaded on any imaging software including the open source software 'ImageJ'.<br><br>
DOI: 10.6084/m9.figshare.5693107.v2
title: Senegal_medical_CT_complete_nest

description: The raw file contains 3D X-ray tomographic image of a termite nest constructed by <i>Trinervitermes trinervoides</i> termites. The nest was collected from Nguekokh, Senegal during early October 2010. The nest was in Savanna type vegetation, and was exposed to the sun.<br>The file size is 512, 512 and 369 pixels, with pixel size 0.55, 0.55 and 0.6 mm in X, Y and Z direction respectively. The file format is 8-bit .raw, and can be loaded on any imaging software including the open source software 'ImageJ'. The binary image contains 0 as pores and 1 as solid phase.<br>
DOI: 10.6084/m9.figshare.5693107.v3
title: Senegal_termite_nest_complete_Xray_medical_CT

description: The raw file contains 3D X-ray tomographic image of a termite nest constructed by <i>Trinervitermes trinervoides</i> termites. The nest was collected from Nguekokh, Senegal during early October 2010. The nest was in Savanna type vegetation, and was exposed to the sun.<br>The file size is 512, 512 and 369 pixels, with pixel size 0.55, 0.55 and 0.6 mm in X, Y and Z direction respectively. The file format is 8-bit .raw, and can be loaded on any imaging software including the open source software 'ImageJ'. The binary image contains 0 as pores and 1 as solid phase.<br>
DOI: 10.6084/m9.figshare.5693107.v6
title: Termite Image

description: Image<br>
DOI: 10.6084/m9.figshare.5693107.v7
title: Image

description: Image<br>
DOI: 10.6084/m9.figshare.5693095
title: A Cross-Sectional Study on the Spectrum of HIV-Related Stigma and Disclosure Concerns among People Living with HIV/AIDS (PLWHA) in Abeokuta, Nigeria,

description: This research data was a cross-sectional study that involved assessing HIV-related stigma among people living with HIV/AIDS in Abeokuta, South-West Nigeria. The Berger stigma scale was used and the scores calculated as such. Ethical Approval was obtained from Federal Medical Centre, Abeokuta, Nigeria and University of Roehampton, Uk before commencement of study.
DOI: 10.6084/m9.figshare.5693095.v1
title: A Cross-Sectional Study on the Spectrum of HIV-Related Stigma and Disclosure Concerns among People Living with HIV/AIDS (PLWHA) in Abeokuta, Nigeria,

description: This research data was a cross-sectional study that involved assessing HIV-related stigma among people living with HIV/AIDS in Abeokuta, South-West Nigeria. The Berger stigma scale was used and the scores calculated as such. Ethical Approval was obtained from Federal Medical Centre, Abeokuta, Nigeria and University of Roehampton, Uk before commencement of study.
DOI: 10.6084/m9.figshare.5693089
title: Leopard SECR

description: Detection data for leopard in NE Iran<br>
DOI: 10.6084/m9.figshare.5693053
title: Post-marketing withdrawal of analgesic medications because of adverse drug reactions: a systematic review

description: <b>Introduction</b>: Many analgesics have been withdrawn from the market because of adverse drug reactions. Controversy still surrounds the use of some approved analgesics for pain management. However, the trends and reasons for withdrawal of analgesics when harms are attributed to their use have not been systematically assessed. <b>Areas covered</b>: We conducted searches in PubMed; Embase; Google Scholar; clinicaltrials.gov; WHO databases of withdrawn products; websites of the European Medicines Agency, the US Food and Drug Administration, the UK Medicines and Healthcare products Regulatory Agency; Meyler’s <i>Side Effects of Drugs; Stephens’ Detection of New Adverse Drug Reactions</i>; the <i>Pharmaceutical Manufacturing Encyclopedia</i>; and the <i>Merck Index</i>. We included licensed analgesics that were withdrawn after marketing because of adverse reactions between 1950 and March 2017. We excluded herbal products, non-human medicines, and non-prescription medicines. We used the Oxford Centre for Evidence Based Medicine criteria to document the levels of evidence, and chi-squared tests to compare withdrawal patterns across geographical regions. <b>Expert opinion</b>: Pharmacovigilance systems in low-resource settings should be strengthened. Greater co-ordination across regulatory authorities in assessing and interpreting the benefit-harm balance of new analgesics should be encouraged. Future reporting of harms in clinical trials of analgesics should follow standardized guidelines.
DOI: 10.6084/m9.figshare.5693053.v1
title: Post-marketing withdrawal of analgesic medications because of adverse drug reactions: a systematic review

description: <b>Introduction</b>: Many analgesics have been withdrawn from the market because of adverse drug reactions. Controversy still surrounds the use of some approved analgesics for pain management. However, the trends and reasons for withdrawal of analgesics when harms are attributed to their use have not been systematically assessed. <b>Areas covered</b>: We conducted searches in PubMed; Embase; Google Scholar; clinicaltrials.gov; WHO databases of withdrawn products; websites of the European Medicines Agency, the US Food and Drug Administration, the UK Medicines and Healthcare products Regulatory Agency; Meyler’s <i>Side Effects of Drugs; Stephens’ Detection of New Adverse Drug Reactions</i>; the <i>Pharmaceutical Manufacturing Encyclopedia</i>; and the <i>Merck Index</i>. We included licensed analgesics that were withdrawn after marketing because of adverse reactions between 1950 and March 2017. We excluded herbal products, non-human medicines, and non-prescription medicines. We used the Oxford Centre for Evidence Based Medicine criteria to document the levels of evidence, and chi-squared tests to compare withdrawal patterns across geographical regions. <b>Expert opinion</b>: Pharmacovigilance systems in low-resource settings should be strengthened. Greater co-ordination across regulatory authorities in assessing and interpreting the benefit-harm balance of new analgesics should be encouraged. Future reporting of harms in clinical trials of analgesics should follow standardized guidelines.
DOI: 10.6084/m9.figshare.5692957
title: Supplementary Material for: Predicting Trajectories of Functional Decline in 60- to 70-Year-Old People

description: <b><i>Background:</i></b> Early identification of people at risk of functional decline is essential for delivering targeted preventive interventions. <b><i>Objective:</i></b> The aim of this study is to identify and predict trajectories of functional decline over 9 years in males and females aged 60-70 years. <b><i>Methods:</i></b> We included 403 community-dwelling participants from the InCHIANTI study and 395 from the LASA study aged 60-70 years at baseline, of whom the majority reported no functional decline at baseline (median 0, interquartile range 0-1). Participants were included if they reported data on ≥2 measurements of functional ability during a 9-year follow-up. Functional ability was scored with 6 self-reported items on activities of daily living. We performed latent class growth analysis to identify trajectories of functional decline and applied multinomial regression models to develop prediction models of identified trajectories. Analyses were stratified for sex. <b><i>Results:</i></b> Three distinct trajectories were identified: no/little decline (219 males, 241 females), intermediate decline (114 males, 158 females), and severe decline (36 males, 30 females). Higher gait speed showed decreased risk of functional limitations in males (intermediate limitations, odds ratio [OR] 0.74, 95% CI 0.57-0.97; severe limitations, OR 0.42, 95% CI 0.26-0.66). The final model in males further included the predictors fear of falling and alcohol intake (no/little decline, area under the receiver operating curve [AUC] 0.68, 95% CI 0.62-0.73; intermediate decline, AUC 0.63, 95% CI 0.56-0.69; severe decline, AUC 0.79, 95% CI 0.71-0.87). In females, higher gait speed showed a decreased risk of intermediate limitations (OR 0.51, 95% CI 0.38-0.68) and severe limitations (OR 0.18, 95% CI 0.07-0.44). Other predictors in females were age, living alone, economic satisfaction, balance, physical activity, BMI, and cardiovascular disease (no/little decline, AUC 0.80, 95% CI 0.75-0.85; intermediate decline, AUC 0.74, 95% CI 0.69-0.79; severe decline, AUC 0.95, 95% CI 0.91-0.99). <b><i>Conclusion:</i></b> Already in people aged 60-70 years, 3 distinct trajectories of functional decline were identified in these cohorts over a 9-year follow-up. Predictors of trajectories differed between males and females, except for gait speed. Identification of people at risk is the basis for targeting interventions.
DOI: 10.6084/m9.figshare.5692945
title: Supplementary Material for: Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies

description: <b><i>Background:</i></b> Psoriasis is an immune-mediated, inflammatory disease. Adipokines contribute to the regulation of immune-mediated processes and inflammation. <b><i>Objective:</i></b> The aim of our study was to systematically review the literature for studies that have evaluated the circulating concentrations of adipokines in patients with psoriasis and controls and to meta-analyze the best evidence available. <b><i>Methods:</i></b> Eligible were studies that have assessed leptin, resistin, or adiponectin concentrations in psoriatic patients and a reference group. The study was conducted in adherence with the PRISMA standards. <b><i>Results:</i></b> Psoriatic patients had higher leptin concentrations compared to controls (random effects model, mean difference, MD = 5.64 ng/mL, 95% CI: 3.00-8.29, <i>p</i> &lt; 0.0001). Heterogeneity among studies was high (<i>I</i><sup>2</sup> = 95.9%). Psoriatic patients had higher resistin concentrations compared to controls (MD = 4.66 ng/mL, 95% CI: 2.62-6.69, <i>p</i> &lt; 0.0001). Heterogeneity was high (<i>I</i><sup>2</sup> = 99.2%). Finally, psoriatic patients had lower adiponectin concentrations compared to controls (MD = -1.87 μg/mL, 95% CI: -2.76 to -0.98, <i>p</i> &lt; 0.0001). Heterogeneity was high (<i>I</i><sup>2</sup> = 95.9%). <b><i>Conclusion:</i></b> The study supported the hypothesis that leptin and resistin concentrations are higher and adiponectin concentrations are lower in patients with psoriasis compared to controls. Hereby, the suggested pathogenic link between psoriasis and metabolic syndrome/obesity is reinforced and the role of comorbidities in psoriasis is highlighted.
DOI: 10.6084/m9.figshare.5692933
title: Intrinsic ankle stiffness during standing increases with ankle torque and passive stretch of the Achilles tendon _ Study 1 dataset

description: Dataset used for study 1 (ankle torque). <br><br>pXX__normal / vertical / lean = trials recorded with perturbations to measure stiffness<br><br>pXX__topplingtorque = trials recorded for toppling torque per unit angle estimation, in which participants were swaying backwards/forwards very gently<br><br>pXX_standing_normal / vertical / lean = trials recorded without perturbations, in which participants were standing quietly at preferred forward leaning position<br><br>Data recordings are distributed as:<br> <br>pos=calibrate(Dataset(:,2),potCF); % footplate angular rotation<br>LTq=calibrate(Dataset(:,4),ltqCF); % left torque<br>acc=Dataset(:,3); acc=calibrate(acc,accCF); % acceleration<br>laser1=calibrate(Dataset(:,6),laser1CF); <br>shinpos=atan(laser1./laserH1); % calculate angular rotation with atan of tan=linear displacement/laser height <br>anklepos=pos+shinpos; % ankle angular rotation<br>laser2=calibrate(Dataset(:,7),laser2CF); boardpos=atan(laser2./laserH2); <br>bodypos=pos+boardpos; % body angular rotation <br>EMG1=abs(Dataset(:,8)); % channel 7 EMG1 (left tibialis anterior)<br>EMG2=abs(Dataset(:,9)); % channel 8 EMG2 (left medial gastrocnemius)<br>EMG3=abs(Dataset(:,10)); % channel 9 EMG3 (right tibialis anterior)<br>EMG4=abs(Dataset(:,11)); % channel 10 EMG4 (right medial gastrocnemius)<br><br>Calibration: <br> Motor: 0,6 <br>Potentiometer (rad): 0,0253 <br>Potentiometer (deg): 1,45 <br>Left load cell: -9,88 <br>Right load cell: -20,6 <br>Accelerometer: -127,681 <br>Laser #1: 0,01 <br>Laser #2: 0,02
DOI: 10.6084/m9.figshare.5692933.v1
title: Intrinsic ankle stiffness during standing increases with ankle torque and passive stretch of the Achilles tendon _ Study 1 dataset

description: Dataset used for study 1 (ankle torque). <br><br>pXX__normal / vertical / lean = trials recorded with perturbations to measure stiffness<br><br>pXX__topplingtorque = trials recorded for toppling torque per unit angle estimation, in which participants were swaying backwards/forwards very gently<br><br>pXX_standing_normal / vertical / lean = trials recorded without perturbations, in which participants were standing quietly at preferred forward leaning position<br><br>Data recordings are distributed as:<br> <br>pos=calibrate(Dataset(:,2),potCF); % footplate angular rotation<br>LTq=calibrate(Dataset(:,4),ltqCF); % left torque<br>acc=Dataset(:,3); acc=calibrate(acc,accCF); % acceleration<br>laser1=calibrate(Dataset(:,6),laser1CF); <br>shinpos=atan(laser1./laserH1); % calculate angular rotation with atan of tan=linear displacement/laser height <br>anklepos=pos+shinpos; % ankle angular rotation<br>laser2=calibrate(Dataset(:,7),laser2CF); boardpos=atan(laser2./laserH2); <br>bodypos=pos+boardpos; % body angular rotation <br>EMG1=abs(Dataset(:,8)); % channel 7 EMG1 (left tibialis anterior)<br>EMG2=abs(Dataset(:,9)); % channel 8 EMG2 (left medial gastrocnemius)<br>EMG3=abs(Dataset(:,10)); % channel 9 EMG3 (right tibialis anterior)<br>EMG4=abs(Dataset(:,11)); % channel 10 EMG4 (right medial gastrocnemius)<br><br>Calibration: <br> Motor: 0,6 <br>Potentiometer (rad): 0,0253 <br>Potentiometer (deg): 1,45 <br>Left load cell: -9,88 <br>Right load cell: -20,6 <br>Accelerometer: -127,681 <br>Laser #1: 0,01 <br>Laser #2: 0,02