cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.7901972
title: Supplementary Material for: Modifying Effect of Statins on Fatal Outcomes in Chronic Kidney Disease Patients in the Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis

description: <b><i>Background:</i></b> Management of chronic kidney disease (CKD) patients includes efforts directed toward modifying traditional cardiovascular risk factors. Such efforts include optimal management of hypertension together with the initiation of statin therapy. <b><i>Methods:</i></b> In this observational study, we determine the modifying effect of statins on the relationship of systolic blood pressure (SBP) goal with mortality and other outcomes in patients with CKD participating in a clinical trial. At baseline, 2,646 CKD patients (estimated glomerular filtration rate &lt; 60 mL/min/1.73 m<sup>2</sup>) were randomized to an intensive SBP goal &lt; 120 mm Hg or standard SBP goal &lt;140 mm Hg. One thousand two hundred and seventy-three were not on statin, 1,354 were on a statin, and in 19 the use of statin was unknown. The 2 primary outcomes were all-cause mortality and cardiovascular disease (CVD) mortality. <b><i>Results:</i></b> The relationships of SBP goal with all-cause mortality (interaction <i>p</i> = 0.009) and cardiovascular (CV) mortality (interaction <i>p</i> = 0.021) were modified by the use of statin after adjusting for age, gender, race, CVD history, smoking, aspirin use, and blood pressure at baseline. In the statin group, targeting SBP to &lt; 120 mm Hg compared to SBP &lt; 140 mm Hg significantly reduced the risk of all-cause mortality (adjusted hazard ratio [aHR] 0.44 [0.28–0.71]; event rates 1.16 vs. 2.5 per 100 patient-years) and CV mortality (aHR 0.29 [0.12–0.74]; event rates 0.28 vs. 0.92 per 100 patient-years) after a median follow-up of 3.26 years. In the non-statin group, the risk of all-cause mortality (aHR 1.07 [0.69–1.66]; event rates 2.01 vs. 1.94 per 100 patient-years) and CV mortality (aHR 1.42 [0.56–3.59]; event rates 0.52 vs. 0.41 per 100 patient-years) were not significantly different in both SBP goal arms. <b><i>Conclusion:</i></b> The combination of statin therapy and intensive SBP management leads to improved survival in hypertensive patients with CKD.
DOI: 10.6084/m9.figshare.7902047.v1
title: Supplementary Material for: Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients

description: <b><i>Background:</i></b> Mortality in hemodialysis patients still remains unacceptably high. Enhanced arterial stiffness is a known cardiovascular risk factor, and pulse wave velocity (PWV) has proven to be a valid parameter to quantify risk. Recent studies showed controversial results regarding the prognostic significance of PWV for mortality in hemodialysis patients, which may be due to methodological issues, such as assessment of PWV in the office setting (Office-PWV). <b><i>Method:</i></b> This study cohort contains patients from the “Risk stratification in end-stage renal disease – the ISAR study,” a multicenter prospective longitudinal observatory cohort study. We examined and compared the predictive value of ambulatory 24-hour PWV (24 h-PWV) and Office-PWV on mortality in a total of 344 hemodialysis patients. The endpoints of the study were all-cause and cardiovascular mortality. Survival analysis included Kaplan-Meier estimates and Cox regression analysis. <b><i>Results:</i></b> During a follow-up of 36 months, a total of 89 patients died, 35 patients due to cardiovascular cause. Kaplan-Meier estimates for tertiles of 24 h-PWV and Office-PWV were similarly associated with mortality. In univariate Cox regression analysis, 24 h-PWV and Office-PWV were equivalent predictors for all-cause and cardiovascular mortality. After adjustment for common risk factors, only 24 h-PWV remained solely predictive for all-cause mortality (hazard ratio 2.51 [95% CI 1.31–4.81]; <i>p</i> = 0.004). <b><i>Conclusions:</i></b> Comparing both measurements, 24 h-PWV is an independent predictor for all-cause-mortality in hemodialysis patients beyond Office-PWV.
DOI: 10.6084/m9.figshare.7901972.v1
title: Supplementary Material for: Modifying Effect of Statins on Fatal Outcomes in Chronic Kidney Disease Patients in the Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis

description: <b><i>Background:</i></b> Management of chronic kidney disease (CKD) patients includes efforts directed toward modifying traditional cardiovascular risk factors. Such efforts include optimal management of hypertension together with the initiation of statin therapy. <b><i>Methods:</i></b> In this observational study, we determine the modifying effect of statins on the relationship of systolic blood pressure (SBP) goal with mortality and other outcomes in patients with CKD participating in a clinical trial. At baseline, 2,646 CKD patients (estimated glomerular filtration rate &lt; 60 mL/min/1.73 m<sup>2</sup>) were randomized to an intensive SBP goal &lt; 120 mm Hg or standard SBP goal &lt;140 mm Hg. One thousand two hundred and seventy-three were not on statin, 1,354 were on a statin, and in 19 the use of statin was unknown. The 2 primary outcomes were all-cause mortality and cardiovascular disease (CVD) mortality. <b><i>Results:</i></b> The relationships of SBP goal with all-cause mortality (interaction <i>p</i> = 0.009) and cardiovascular (CV) mortality (interaction <i>p</i> = 0.021) were modified by the use of statin after adjusting for age, gender, race, CVD history, smoking, aspirin use, and blood pressure at baseline. In the statin group, targeting SBP to &lt; 120 mm Hg compared to SBP &lt; 140 mm Hg significantly reduced the risk of all-cause mortality (adjusted hazard ratio [aHR] 0.44 [0.28–0.71]; event rates 1.16 vs. 2.5 per 100 patient-years) and CV mortality (aHR 0.29 [0.12–0.74]; event rates 0.28 vs. 0.92 per 100 patient-years) after a median follow-up of 3.26 years. In the non-statin group, the risk of all-cause mortality (aHR 1.07 [0.69–1.66]; event rates 2.01 vs. 1.94 per 100 patient-years) and CV mortality (aHR 1.42 [0.56–3.59]; event rates 0.52 vs. 0.41 per 100 patient-years) were not significantly different in both SBP goal arms. <b><i>Conclusion:</i></b> The combination of statin therapy and intensive SBP management leads to improved survival in hypertensive patients with CKD.
DOI: 10.6084/m9.figshare.7901840
title: Social Interaction test videos registered on day 3 in adult Japanese quail

description: Social Interaction test videos of the second day of testing. Japanese quail test birds were placed in a novel test environment and after an adaptation period were exposed to a photocastrated (non-aggressive) opponent. All birds were tested only once over a 5 day period. Video file names provide the ID of the animal testes. For description of test see Caliva et al. (2017) http://dx.doi.org/10.3382/ps/pex258
DOI: 10.6084/m9.figshare.7901846
title: Partial Mechanical Restraint video files of juvenile Japanese quail (second half)

description: Partial Mechanical Restraint was performed on juvenile Japanese quail (40 days of age). Test consisted in restricting the movement of the animal between two walls of a melamine box of 20 x 10 cm (height per width, respectively) with the characteristic that the front wall was made of glass, and the back wall was adjustable to induce immobility in such a way that the animal cannot open the wings, but can move the head and legs. The experimenters retreated out of the birds' sight, and the test was during 5 minutes recorded with a video camera place in front of the box. All the birds were tested in 31 batches of 4 animals each, where the birds had no visual or physical contact between each other. File name includes the ID number of the four birds tested.
DOI: 10.6084/m9.figshare.7901846.v1
title: Partial Mechanical Restraint video files of juvenile Japanese quail (second half)

description: Partial Mechanical Restraint was performed on juvenile Japanese quail (40 days of age). Test consisted in restricting the movement of the animal between two walls of a melamine box of 20 x 10 cm (height per width, respectively) with the characteristic that the front wall was made of glass, and the back wall was adjustable to induce immobility in such a way that the animal cannot open the wings, but can move the head and legs. The experimenters retreated out of the birds' sight, and the test was during 5 minutes recorded with a video camera place in front of the box. All the birds were tested in 31 batches of 4 animals each, where the birds had no visual or physical contact between each other. File name includes the ID number of the four birds tested.
DOI: 10.6084/m9.figshare.7901786
title: Poster for EGU 2019: Predicted statistics of coronal mass ejections observed by Parker Solar Probe and forward modeling of their in situ magnetic field

description: This poster was shown at EGU 2019.
DOI: 10.6084/m9.figshare.7901840.v1
title: Social Interaction test videos registered on day 3 in adult Japanese quail

description: Social Interaction test videos of the second day of testing. Japanese quail test birds were placed in a novel test environment and after an adaptation period were exposed to a photocastrated (non-aggressive) opponent. All birds were tested only once over a 5 day period. Video file names provide the ID of the animal testes. For description of test see Caliva et al. (2017) http://dx.doi.org/10.3382/ps/pex258
DOI: 10.6084/m9.figshare.7901768
title: IYK edit 020819 DHT AR Supplement Figures.pptx

description: Endocrinology journal supplement data set
DOI: 10.6084/m9.figshare.7901786.v2
title: Poster for EGU 2019: Predicted statistics of coronal mass ejections observed by Parker Solar Probe and forward modeling of their in situ magnetic field

description: This poster was shown at EGU 2019.
DOI: 10.6084/m9.figshare.7901768.v1
title: IYK edit 020819 DHT AR Supplement Figures.pptx

description: Endocrinology journal supplement data set
DOI: 10.6084/m9.figshare.7901594
title: Supplementary Material for: Feasibility and Acceptability of an Intervention Providing Computer-Generated Tailored Feedback to Target Alcohol Consumption and Depressive Symptoms in Proactively Recruited Health Care Patients and Reactively Recruited Media Volunteers: Results of a Pilot Study

description: <b><i>Background:</i></b> A pre-post pilot study was conducted to test the feasibility, acceptability, and potential effectiveness of a fully automatized computer-based intervention targeting hazardous drinking and depressiveness in proactively recruited health care patients (HCPs). To address the importance of the sample selection when testing interventions, HCPs were compared to media recruited volunteers (MVs). <b><i>Method:</i></b> In a multicenter screening program 2,773 HCPs were screened for hazardous drinking and depressive symptoms. MVs were recruited via media solicitation. Over a period of 6 months, study participants received 6 individualized counseling letters and weekly short messages. Pre-post data were analyzed for 30 participants (15 HCPs, 15 MVs). Intervention acceptability was assessed in post-intervention interviews conducted with 32 study participants. <b><i>Results:</i></b> MVs showed higher problem severity and motivation to change than HCPs. Over the course of the intervention both subsamples reduced regular binge drinking (HCPs: <i>p</i> = 0.016; MVs: <i>p</i> = 0.031) and depressiveness (HCPs: <i>p</i> = 0.020; MVs: <i>p</i> &lt; 0.001). MVs further reduced average daily alcohol consumption (<i>p</i> = 0.034). The intervention received positive ratings from both subsamples, the alcohol module was rated more favorably by MVs than by HCPs (<i>p</i> = 0.012). Subsamples further differed in terms of intervention usage (<i>p</i> = 0.013). <b><i>Conclusion:</i></b> The intervention was technically and logistically feasible, well accepted, and may have the potential to reduce hazardous drinking and depressive symptoms in different populations. Subsamples differed in terms of problem severity, motivation to change, intervention usage, pre-post changes, and attitudes toward the intervention, showing that intervention development should involve the intended target populations to avoid biased conclusions on intervention effectiveness and acceptability.
DOI: 10.6084/m9.figshare.7901594.v1
title: Supplementary Material for: Feasibility and Acceptability of an Intervention Providing Computer-Generated Tailored Feedback to Target Alcohol Consumption and Depressive Symptoms in Proactively Recruited Health Care Patients and Reactively Recruited Media Volunteers: Results of a Pilot Study

description: <b><i>Background:</i></b> A pre-post pilot study was conducted to test the feasibility, acceptability, and potential effectiveness of a fully automatized computer-based intervention targeting hazardous drinking and depressiveness in proactively recruited health care patients (HCPs). To address the importance of the sample selection when testing interventions, HCPs were compared to media recruited volunteers (MVs). <b><i>Method:</i></b> In a multicenter screening program 2,773 HCPs were screened for hazardous drinking and depressive symptoms. MVs were recruited via media solicitation. Over a period of 6 months, study participants received 6 individualized counseling letters and weekly short messages. Pre-post data were analyzed for 30 participants (15 HCPs, 15 MVs). Intervention acceptability was assessed in post-intervention interviews conducted with 32 study participants. <b><i>Results:</i></b> MVs showed higher problem severity and motivation to change than HCPs. Over the course of the intervention both subsamples reduced regular binge drinking (HCPs: <i>p</i> = 0.016; MVs: <i>p</i> = 0.031) and depressiveness (HCPs: <i>p</i> = 0.020; MVs: <i>p</i> &lt; 0.001). MVs further reduced average daily alcohol consumption (<i>p</i> = 0.034). The intervention received positive ratings from both subsamples, the alcohol module was rated more favorably by MVs than by HCPs (<i>p</i> = 0.012). Subsamples further differed in terms of intervention usage (<i>p</i> = 0.013). <b><i>Conclusion:</i></b> The intervention was technically and logistically feasible, well accepted, and may have the potential to reduce hazardous drinking and depressive symptoms in different populations. Subsamples differed in terms of problem severity, motivation to change, intervention usage, pre-post changes, and attitudes toward the intervention, showing that intervention development should involve the intended target populations to avoid biased conclusions on intervention effectiveness and acceptability.
DOI: 10.6084/m9.figshare.7901531
title: gVCF_HG01840

description: 1000 Genomes gVCF mapped to hs37d5 for HG01840. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901504
title: gVCF_HG03464

description: 1000 Genomes gVCF mapped to hs37d5 for HG03464. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901495
title: gVCF_HG01817

description: 1000 Genomes gVCF mapped to hs37d5 for HG01817. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901504.v1
title: gVCF_HG03464

description: 1000 Genomes gVCF mapped to hs37d5 for HG03464. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901531.v1
title: gVCF_HG01840

description: 1000 Genomes gVCF mapped to hs37d5 for HG01840. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901444
title: gVCF_HG03461

description: 1000 Genomes gVCF mapped to hs37d5 for HG03461. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901459
title: gVCF_HG01815

description: 1000 Genomes gVCF mapped to hs37d5 for HG01815. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901480
title: gVCF_HG01816

description: 1000 Genomes gVCF mapped to hs37d5 for HG01816. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901444.v1
title: gVCF_HG03461

description: 1000 Genomes gVCF mapped to hs37d5 for HG03461. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901459.v1
title: gVCF_HG01815

description: 1000 Genomes gVCF mapped to hs37d5 for HG01815. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901480.v1
title: gVCF_HG01816

description: 1000 Genomes gVCF mapped to hs37d5 for HG01816. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901432
title: gVCF_HG01813

description: 1000 Genomes gVCF mapped to hs37d5 for HG01813. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901435
title: Selected raw data of wave experiments Shkorpilovtsy2007 and Tainan2015

description: Selected raw data of wave experiments Shkorpilovtsy2007 and Tainan2015.Two wave records of wave measurements experiments. Tainan2015 - laboratory experiment, transformation of initial monochromatic wave on gentle slope 0.01.Shkorpilovtsy2007 - field experiment, transformation of irregular waves in coastal zone.
DOI: 10.6084/m9.figshare.7901426
title: gVCF_HG01812

description: 1000 Genomes gVCF mapped to hs37d5 for HG01812. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901432.v1
title: gVCF_HG01813

description: 1000 Genomes gVCF mapped to hs37d5 for HG01813. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901384
title: SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

description: The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC<sub>50</sub> values were found to be in the micromolar to submicromolar range. The <i>K<sub>i</sub></i> values of compound 16 were determined to be 0.047 and 0.020 μM for the inhibition of MAO-A and MAO-B, respectively. Dialysis of enzyme-inhibitor mixtures indicated a reversible competitive mode of inhibition. Most of the synthesized chalcone analogs showed a better selectivity toward MAO-B. However, introducing of 2,4,6-trimethoxy substituents on ring B shifted the selectivity toward MAO-A. In addition, we investigated the molecular mechanism of MAO-B inhibition by selected chalcone analogs. Our results revealed that these selected chalcone analogs increased dopamine levels in the rat hepatoma (H4IIE) cells and decreased the relative mRNA expression of the MAO-B enzyme.
DOI: 10.6084/m9.figshare.7901387
title: gVCF_HG01811

description: 1000 Genomes gVCF mapped to hs37d5 for HG01811. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901396
title: gVCF_HG03460

description: 1000 Genomes gVCF mapped to hs37d5 for HG03460. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901396.v1
title: gVCF_HG03460

description: 1000 Genomes gVCF mapped to hs37d5 for HG03460. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901435.v2
title: Selected raw data of wave experiments Shkorpilovtsy2007 and Tainan2015

description: Selected raw data of wave experiments Shkorpilovtsy2007 and Tainan2015.Two wave records of wave measurements experiments. Tainan2015 - laboratory experiment, transformation of initial monochromatic wave on gentle slope 0.01.Shkorpilovtsy2007 - field experiment, transformation of irregular waves in coastal zone.
DOI: 10.6084/m9.figshare.7901384.v1
title: SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

description: The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC<sub>50</sub> values were found to be in the micromolar to submicromolar range. The <i>K<sub>i</sub></i> values of compound 16 were determined to be 0.047 and 0.020 μM for the inhibition of MAO-A and MAO-B, respectively. Dialysis of enzyme-inhibitor mixtures indicated a reversible competitive mode of inhibition. Most of the synthesized chalcone analogs showed a better selectivity toward MAO-B. However, introducing of 2,4,6-trimethoxy substituents on ring B shifted the selectivity toward MAO-A. In addition, we investigated the molecular mechanism of MAO-B inhibition by selected chalcone analogs. Our results revealed that these selected chalcone analogs increased dopamine levels in the rat hepatoma (H4IIE) cells and decreased the relative mRNA expression of the MAO-B enzyme.
DOI: 10.6084/m9.figshare.7901435.v1
title: Selected raw data of wave experiments Shkorpilovtsy2007 and Tainan2015

description: Selected raw data of wave experiments Shkorpilovtsy2007 and Tainan2015.Two wave records of wave measurements experiments. Tainan2015 - laboratory experiment, transformation of initial monochromatic wave on gentle slope 0.01.Shkorpilovtsy2007 - field experiment, transformation of irregular waves in coastal zone.
DOI: 10.6084/m9.figshare.7901372
title: gVCF_HG01810

description: 1000 Genomes gVCF mapped to hs37d5 for HG01810. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901369
title: gVCF_HG03458

description: 1000 Genomes gVCF mapped to hs37d5 for HG03458. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901357
title: gVCF_HG03457

description: 1000 Genomes gVCF mapped to hs37d5 for HG03457. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901360
title: gVCF_HG01809

description: 1000 Genomes gVCF mapped to hs37d5 for HG01809. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901372.v1
title: gVCF_HG01810

description: 1000 Genomes gVCF mapped to hs37d5 for HG01810. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901360.v1
title: gVCF_HG01809

description: 1000 Genomes gVCF mapped to hs37d5 for HG01809. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901369.v1
title: gVCF_HG03458

description: 1000 Genomes gVCF mapped to hs37d5 for HG03458. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901348
title: gVCF_HG01807

description: 1000 Genomes gVCF mapped to hs37d5 for HG01807. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901348.v1
title: gVCF_HG01807

description: 1000 Genomes gVCF mapped to hs37d5 for HG01807. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901354
title: gVCF_HG01808

description: 1000 Genomes gVCF mapped to hs37d5 for HG01808. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901357.v1
title: gVCF_HG03457

description: 1000 Genomes gVCF mapped to hs37d5 for HG03457. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901339
title: gVCF_HG03452

description: 1000 Genomes gVCF mapped to hs37d5 for HG03452. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901342
title: gVCF_HG01806

description: 1000 Genomes gVCF mapped to hs37d5 for HG01806. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901345
title: gVCF_HG03455

description: 1000 Genomes gVCF mapped to hs37d5 for HG03455. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901354.v1
title: gVCF_HG01808

description: 1000 Genomes gVCF mapped to hs37d5 for HG01808. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.7901339.v1
title: gVCF_HG03452

description: 1000 Genomes gVCF mapped to hs37d5 for HG03452. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307