cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.30985486
title: Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy pathways: macroautophagy and chaperone-mediated autophagy

description: Co-adaptation between viruses and autophagy has equipped viruses with diverse strategies to regulate host redox homeostasis, thereby facilitating viral replication. However, the mechanisms by which viruses manipulate PRDX1 (peroxiredoxin 1), a key antioxidative enzyme, via autophagy remain poorly understood. Here, we demonstrate that infection by Senecavirus A (SVA), an emerging picornavirus, induces PRDX1 degradation, and that PRDX1 negatively regulates viral replication. Decreased PRDX1 expression impairs cellular antioxidant defenses, leading to enhanced reactive oxygen species generation that facilitates SVA replication. Screening of viral proteins revealed that SVA VP1, VP2, and 3A induce PRDX1 degradation through vesicle formation-dependent macroautophagy. Notably, viral VP2 can also recruit HSPA8/HSC70 to specifically target PRDX1, directing it for degradation via LAMP2A-mediated chaperone-mediated autophagy (CMA). Collectively, these findings demonstrate that the SVA VP2 protein plays a central role in orchestrating both macroautophagy- and CMA-mediated PRDX1 degradation, establishing PRDX1 as a potential intervention target for countering SVA infection. <b>Abbreviations:</b> AKT/protein kinase B: AKT serine/threonine kinase; ATP: adenosine triphosphate; BHK-21: baby hamster kidney-21; CAT: catalase; CCCP: BMDMs: bone marrow-derived macrophages; CMA: chaperone-mediated autophagy; co-IP: co-immunoprecipitation; CCCP: carbonyl cyanide 3-chlorophenylhydrazone; CQ: chloroquine; DCFH-DA: 2‘,7’-dichlorodihydrofluorescein diacetate; DMSO: dimethyl sulfoxide; GFP: green fluorescent protein; GPX: glutathione peroxidase; GSH: glutathione; HEK-293T: human embryonic kidney 293T; hpi: hours post-infection; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; KO: knockout; LAMP2A: lysosomal associated membrane protein 2A; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; Mdivi-1: mitochondrial division inhibitor-1; mM: millimole; MMP: mitochondrial membrane potential; mPTP: mitochondrial permeability transition pore; MTOR: mechanistic target of rapamycin kinase; NAC: N-acetylcysteine; PI3K: phosphoinositide 3-kinase; PRDX1: peroxiredoxin 1; RT-qPCR: real-time quantitative reverse transcription polymerase chain reaction; ROS: reactive oxygen species; SD: standard deviation; SOD: superoxide dismutase; SQSTM1: sequestosome 1; SVA: Senecavirus A; TIMM23: translocase of inner mitochondrial membrane 23; TOMM20: translocase of outer mitochondrial membrane 20; WT: wild-type; μg: microgram; μm: micrometer; μM: micromolar.
DOI: 10.6084/m9.figshare.30985486.v1
title: Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy pathways: macroautophagy and chaperone-mediated autophagy

description: Co-adaptation between viruses and autophagy has equipped viruses with diverse strategies to regulate host redox homeostasis, thereby facilitating viral replication. However, the mechanisms by which viruses manipulate PRDX1 (peroxiredoxin 1), a key antioxidative enzyme, via autophagy remain poorly understood. Here, we demonstrate that infection by Senecavirus A (SVA), an emerging picornavirus, induces PRDX1 degradation, and that PRDX1 negatively regulates viral replication. Decreased PRDX1 expression impairs cellular antioxidant defenses, leading to enhanced reactive oxygen species generation that facilitates SVA replication. Screening of viral proteins revealed that SVA VP1, VP2, and 3A induce PRDX1 degradation through vesicle formation-dependent macroautophagy. Notably, viral VP2 can also recruit HSPA8/HSC70 to specifically target PRDX1, directing it for degradation via LAMP2A-mediated chaperone-mediated autophagy (CMA). Collectively, these findings demonstrate that the SVA VP2 protein plays a central role in orchestrating both macroautophagy- and CMA-mediated PRDX1 degradation, establishing PRDX1 as a potential intervention target for countering SVA infection. <b>Abbreviations:</b> AKT/protein kinase B: AKT serine/threonine kinase; ATP: adenosine triphosphate; BHK-21: baby hamster kidney-21; CAT: catalase; CCCP: BMDMs: bone marrow-derived macrophages; CMA: chaperone-mediated autophagy; co-IP: co-immunoprecipitation; CCCP: carbonyl cyanide 3-chlorophenylhydrazone; CQ: chloroquine; DCFH-DA: 2‘,7’-dichlorodihydrofluorescein diacetate; DMSO: dimethyl sulfoxide; GFP: green fluorescent protein; GPX: glutathione peroxidase; GSH: glutathione; HEK-293T: human embryonic kidney 293T; hpi: hours post-infection; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; KO: knockout; LAMP2A: lysosomal associated membrane protein 2A; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; Mdivi-1: mitochondrial division inhibitor-1; mM: millimole; MMP: mitochondrial membrane potential; mPTP: mitochondrial permeability transition pore; MTOR: mechanistic target of rapamycin kinase; NAC: N-acetylcysteine; PI3K: phosphoinositide 3-kinase; PRDX1: peroxiredoxin 1; RT-qPCR: real-time quantitative reverse transcription polymerase chain reaction; ROS: reactive oxygen species; SD: standard deviation; SOD: superoxide dismutase; SQSTM1: sequestosome 1; SVA: Senecavirus A; TIMM23: translocase of inner mitochondrial membrane 23; TOMM20: translocase of outer mitochondrial membrane 20; WT: wild-type; μg: microgram; μm: micrometer; μM: micromolar.
DOI: 10.5281/zenodo.18125455
title: Linked collectors and determiners for: Gaultheria (Ericaceae) of Myanmar: an updated species list for the country, a new species, and a new species combination.

description: Natural history specimen data linked to collectors and determiners held within, "Gaultheria (Ericaceae) of Myanmar: an updated species list for the country, a new species, and a new species combination". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/651bce3c-751a-47e3-956c-dc4a73574771 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/651bce3c-751a-47e3-956c-dc4a73574771. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125458
title: Linked collectors and determiners for: Revision of Alpheus euphrosyne De Man, 1897 and A. microrhynchus De Man, 1897, with description of three new species and taxonomic remarks on several other morphologically and ecologically similar snapping shrimps (Malacostraca: Decapoda: Alpheidae).

description: Natural history specimen data linked to collectors and determiners held within, "Revision of Alpheus euphrosyne De Man, 1897 and A. microrhynchus De Man, 1897, with description of three new species and taxonomic remarks on several other morphologically and ecologically similar snapping shrimps (Malacostraca: Decapoda: Alpheidae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7912c179-a542-47d7-9b44-6af1c9185a23 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7912c179-a542-47d7-9b44-6af1c9185a23. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125460
title: Linked collectors and determiners for: Transects performed at S. Tome Island - Project Flora Ameaçada.

description: Natural history specimen data linked to collectors and determiners held within, "Transects performed at S. Tome Island - Project Flora Ameaçada". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7e7d19d2-09dc-47f5-a9d5-4c2003df6e07 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7e7d19d2-09dc-47f5-a9d5-4c2003df6e07. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125461
title: Linked collectors and determiners for: Longwood University, Harvill-Stevens Herbarium.

description: Natural history specimen data linked to collectors and determiners held within, "Longwood University, Harvill-Stevens Herbarium". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7e97cc7b-929e-4ce3-be97-504328101673 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7e97cc7b-929e-4ce3-be97-504328101673. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125462
title: Linked collectors and determiners for: Review of Quedius (Coleoptera, Staphylinidae) described from the 1934 expedition by R. Malaise to Myanmar.

description: Natural history specimen data linked to collectors and determiners held within, "Review of Quedius (Coleoptera, Staphylinidae) described from the 1934 expedition by R. Malaise to Myanmar". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7f562ba5-17db-46bf-93e8-4d1ba49c2800 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7f562ba5-17db-46bf-93e8-4d1ba49c2800. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125468
title: Linked collectors and determiners for: Lacewings and allied insects records from Britain and Ireland to 1999.

description: Natural history specimen data linked to collectors and determiners held within, "Lacewings and allied insects records from Britain and Ireland to 1999". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/88159c93-b888-46df-9b97-a3f96c73b75f using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/88159c93-b888-46df-9b97-a3f96c73b75f. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.10510219
title: Linked collectors and determiners for: Lacewings and allied insects records from Britain and Ireland to 1999.

description: Natural history specimen data linked to collectors and determiners held within, "Lacewings and allied insects records from Britain and Ireland to 1999". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/88159c93-b888-46df-9b97-a3f96c73b75f using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/88159c93-b888-46df-9b97-a3f96c73b75f. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125467
title: Linked collectors and determiners for: Metabarcoding occurrences from Kenai National Wildlife Refuge Pollinator Surveys - 2022.

description: Natural history specimen data linked to collectors and determiners held within, "Metabarcoding occurrences from Kenai National Wildlife Refuge Pollinator Surveys - 2022". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/86875091-d166-4986-802a-343b341424c6 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/86875091-d166-4986-802a-343b341424c6. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125478
title: Linked collectors and determiners for: A taxonomic revision of the ecologically important Ochna holstii (Ochnaceae) complex using molecular and morphological data.

description: Natural history specimen data linked to collectors and determiners held within, "A taxonomic revision of the ecologically important Ochna holstii (Ochnaceae) complex using molecular and morphological data". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/954f96c0-684a-41ff-a23a-8287ce9f7e81 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/954f96c0-684a-41ff-a23a-8287ce9f7e81. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125477
title: Linked collectors and determiners for: Isopoda (Interim dataset).

description: Natural history specimen data linked to collectors and determiners held within, "Isopoda (Interim dataset)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/8a37280c-9310-4ce9-835c-5a14d35b84aa using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/8a37280c-9310-4ce9-835c-5a14d35b84aa. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.10510221
title: Linked collectors and determiners for: Isopoda (Interim dataset).

description: Natural history specimen data linked to collectors and determiners held within, "Isopoda (Interim dataset)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/8a37280c-9310-4ce9-835c-5a14d35b84aa using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/8a37280c-9310-4ce9-835c-5a14d35b84aa. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125484
title: Linked collectors and determiners for: Colección de plantas del Herbario Padre Luis Sodiro (QPLS).

description: Natural history specimen data linked to collectors and determiners held within, "Colección de plantas del Herbario Padre Luis Sodiro (QPLS)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/9f23be2d-ee86-4d72-892a-f8d0d4dc27e7 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/9f23be2d-ee86-4d72-892a-f8d0d4dc27e7. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125411
title: GSE20086 Expression Data

description: Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast.

Twenty-one genes (27 probe sets) were up-regulated in CAF, as compared with NF. Known functions of these genes relate to paracrine or intracellular signaling, transcriptional regulation, extracellular matrix and cell adhesion/migration. Ten genes (14 probe sets) were down-regulated in CAF, including the pluripotency transcription factor KLF4. Quantitative RT–PCR analysis of 10 genes validated the array results. Immunohistochemical staining for three gene products confirmed stromal expression in terms of location and relative quantity. Surprisingly, the variability of gene expression was slightly higher in NF than in CAF, suggesting inter-individual heterogeneity of normal stroma.
DOI: 10.5281/zenodo.18125412
title: GSE20086 Expression Data

description: Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast.

Twenty-one genes (27 probe sets) were up-regulated in CAF, as compared with NF. Known functions of these genes relate to paracrine or intracellular signaling, transcriptional regulation, extracellular matrix and cell adhesion/migration. Ten genes (14 probe sets) were down-regulated in CAF, including the pluripotency transcription factor KLF4. Quantitative RT–PCR analysis of 10 genes validated the array results. Immunohistochemical staining for three gene products confirmed stromal expression in terms of location and relative quantity. Surprisingly, the variability of gene expression was slightly higher in NF than in CAF, suggesting inter-individual heterogeneity of normal stroma.
DOI: 10.5281/zenodo.18125485
title: Linked collectors and determiners for: Santa Barbara Museum of Natural History - Invertebrate Zoology.

description: Natural history specimen data linked to collectors and determiners held within, "Santa Barbara Museum of Natural History - Invertebrate Zoology". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/a004778c-d113-479e-a77f-990041283a51 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/a004778c-d113-479e-a77f-990041283a51. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125486
title: Linked collectors and determiners for: Redux Sellow: revealing Sellow's collections from the Herbier Impérial du Brésil at the Paris Herbarium.

description: Natural history specimen data linked to collectors and determiners held within, "Redux Sellow: revealing Sellow's collections from the Herbier Impérial du Brésil at the Paris Herbarium". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/a06b61a9-ba0a-4c4a-83d9-cd520e657bc2 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/a06b61a9-ba0a-4c4a-83d9-cd520e657bc2. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125490
title: Linked collectors and determiners for: Two New Species of Aizoaceae (Ruschieae, Ruschoideae) from the Cape, South Africa..

description: Natural history specimen data linked to collectors and determiners held within, "Two New Species of Aizoaceae (Ruschieae, Ruschoideae) from the Cape, South Africa.". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/aaa7f60d-5843-4d25-80f9-8cf8c8126582 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/aaa7f60d-5843-4d25-80f9-8cf8c8126582. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.10510235
title: Linked collectors and determiners for: Millipede (Diplopoda) records for Britain and Ireland to 2005.

description: Natural history specimen data linked to collectors and determiners held within, "Millipede (Diplopoda) records for Britain and Ireland to 2005". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/b0a1b3d7-4383-4fa5-a5c9-ae2c1124297e using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/b0a1b3d7-4383-4fa5-a5c9-ae2c1124297e. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125492
title: Linked collectors and determiners for: Millipede (Diplopoda) records for Britain and Ireland to 2005.

description: Natural history specimen data linked to collectors and determiners held within, "Millipede (Diplopoda) records for Britain and Ireland to 2005". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/b0a1b3d7-4383-4fa5-a5c9-ae2c1124297e using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/b0a1b3d7-4383-4fa5-a5c9-ae2c1124297e. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125493
title: Linked collectors and determiners for: A review of the Oocyclus Sharp of Ecuador with description of 12 new species (Coleoptera: Hydrophilidae: Laccobiini).

description: Natural history specimen data linked to collectors and determiners held within, "A review of the Oocyclus Sharp of Ecuador with description of 12 new species (Coleoptera: Hydrophilidae: Laccobiini)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/ad5ba4d1-c2ec-42e3-a76d-a5c9b395a6da using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/ad5ba4d1-c2ec-42e3-a76d-a5c9b395a6da. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125498
title: Linked collectors and determiners for: University of Louisiana at Monroe Herbarium, R. Dale Thomas Collection.

description: Natural history specimen data linked to collectors and determiners held within, "University of Louisiana at Monroe Herbarium, R. Dale Thomas Collection". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/bb0366a9-2a7e-44f8-9c9a-e49c23dae2f8 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/bb0366a9-2a7e-44f8-9c9a-e49c23dae2f8. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125499
title: Linked collectors and determiners for: Combining target enrichment and Sanger sequencing data to clarify the systematics of the diverse Neotropical butterfly subtribe Euptychiina (Nymphalidae, Satyrinae).

description: Natural history specimen data linked to collectors and determiners held within, "Combining target enrichment and Sanger sequencing data to clarify the systematics of the diverse Neotropical butterfly subtribe Euptychiina (Nymphalidae, Satyrinae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/bfb878f3-8a74-46d3-a104-36485c32aaba using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/bfb878f3-8a74-46d3-a104-36485c32aaba. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125502
title: Linked collectors and determiners for: Coleção Científica de Mastozoologia da UFPR.

description: Natural history specimen data linked to collectors and determiners held within, "Coleção Científica de Mastozoologia da UFPR". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/c367f3bb-7db1-4cbb-962a-a13615c9b624 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/c367f3bb-7db1-4cbb-962a-a13615c9b624. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125505
title: Linked collectors and determiners for: University of Wisconsin - Eau Claire Herbarium.

description: Natural history specimen data linked to collectors and determiners held within, "University of Wisconsin - Eau Claire Herbarium". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/c924811b-a307-420b-974e-a5f2f24a8b99 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/c924811b-a307-420b-974e-a5f2f24a8b99. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125508
title: Linked collectors and determiners for: Review of Grotiusomyia Girault (Chalcidoidea: Eulophidae), an exclusively New World genus, including 17 new species.

description: Natural history specimen data linked to collectors and determiners held within, "Review of Grotiusomyia Girault (Chalcidoidea: Eulophidae), an exclusively New World genus, including 17 new species". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/cabaaf5e-455a-4c57-84ca-aed0c83106ec using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/cabaaf5e-455a-4c57-84ca-aed0c83106ec. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125509
title: Linked collectors and determiners for: The Australambrysus plax (La Rivers, 1967) species complex (Heteroptera: Naucoridae), with descriptions of three new species.

description: Natural history specimen data linked to collectors and determiners held within, "The Australambrysus plax (La Rivers, 1967) species complex (Heteroptera: Naucoridae), with descriptions of three new species". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/cfbb52ed-2386-48ed-a227-a6da03b83539 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/cfbb52ed-2386-48ed-a227-a6da03b83539. Formatted as a Frictionless Data package.
DOI: 10.5281/zenodo.18125273
title: A global dataset of net nitrogen mineralization rates under current and future climate scenarios

description: The file "Ecosystem_β_Nmin.tif" represents the spatial distribution of nitrogen mineralization rates in global ecosystems (cropland, grassland, and forest) under different climate models (SSP1-2.6, SSP2-4.5, SSP5-8.5). "cropland_β_Nmin.tif" represents the spatial distribution of cropland ecosystems across various SSPβ scenarios. "grassland_β_Nmin.tif" represents the spatial distribution of grassland ecosystems under different SSPβ scenarios. "forest_β_Nmin.tif" represents the spatial distribution of forest ecosystems across different SSPβ scenarios.