cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.13130/rd_unimi/cmir61/u8abg9
title: Agosto_1897_Pagina_004.jpg

description: Bulletin of 1897/08/01
DOI: 10.13130/rd_unimi/cmir61/gckjrc
title: Agosto_1897_Pagina_006.jpg

description: Bulletin of 1897/08/02
DOI: 10.13130/rd_unimi/cmir61/zpcahu
title: Agosto_1897_Pagina_005.jpg

description: Bulletin of 1897/08/02
DOI: 10.13130/rd_unimi/cmir61/imy1fe
title: Agosto_1897_Pagina_007.jpg

description: Bulletin of 1897/08/02
DOI: 10.13130/rd_unimi/cmir61/ocb8fc
title: Agosto_1897_Pagina_008.jpg

description: Bulletin of 1897/08/02
DOI: 10.13130/rd_unimi/cmir61/dvg7uu
title: Agosto_1897_Pagina_009.jpg

description: Bulletin of 1897/08/03
DOI: 10.13130/rd_unimi/cmir61/r3fu1h
title: Agosto_1897_Pagina_011.jpg

description: Bulletin of 1897/08/03
DOI: 10.13130/rd_unimi/cmir61/vu3zj1
title: Agosto_1897_Pagina_010.jpg

description: Bulletin of 1897/08/03
DOI: 10.13130/rd_unimi/cmir61/hwbl0x
title: Agosto_1897_Pagina_012.jpg

description: Bulletin of 1897/08/03
DOI: 10.13130/rd_unimi/cmir61/mki6tm
title: Agosto_1897_Pagina_013.jpg

description: Bulletin of 1897/08/04
DOI: 10.13130/rd_unimi/cmir61/pimdfe
title: Agosto_1897_Pagina_015.jpg

description: Bulletin of 1897/08/04
DOI: 10.13130/rd_unimi/cmir61/qqnsbq
title: Agosto_1897_Pagina_014.jpg

description: Bulletin of 1897/08/04
DOI: 10.13130/rd_unimi/cmir61/0n35ee
title: Agosto_1897_Pagina_016.jpg

description: Bulletin of 1897/08/04
DOI: 10.13130/rd_unimi/cmir61/vj02kp
title: Agosto_1897_Pagina_017.jpg

description: Bulletin of 1897/08/05
DOI: 10.13130/rd_unimi/cmir61/hvtik8
title: Agosto_1897_Pagina_018.jpg

description: Bulletin of 1897/08/05
DOI: 10.13130/rd_unimi/depg5t/ecjpcy
title: Agosto_1898_Pagina_001.jpg

description: Bulletin of 1898/08/01
DOI: 10.13130/rd_unimi/cmir61/kzqyqn
title: Agosto_1897_Pagina_019.jpg

description: Bulletin of 1897/08/05
DOI: 10.13130/rd_unimi/cmir61/pzy02q
title: Agosto_1897_Pagina_020.jpg

description: Bulletin of 1897/08/05
DOI: 10.13130/rd_unimi/depg5t/j0fyos
title: Agosto_1898_Pagina_002.jpg

description: Bulletin of 1898/08/01
DOI: 10.13130/rd_unimi/cmir61/r4q2sz
title: Agosto_1897_Pagina_021.jpg

description: Bulletin of 1897/08/06
DOI: 10.13130/rd_unimi/depg5t/2tgttc
title: Agosto_1898_Pagina_003.jpg

description: Bulletin of 1898/08/01
DOI: 10.13130/rd_unimi/cmir61/dyamzo
title: Agosto_1897_Pagina_022.jpg

description: Bulletin of 1897/08/06
DOI: 10.13130/rd_unimi/depg5t/0wl4g2
title: Agosto_1898_Pagina_004.jpg

description: Bulletin of 1898/08/01
DOI: 10.13130/rd_unimi/cmir61/gs8lzh
title: Agosto_1897_Pagina_023.jpg

description: Bulletin of 1897/08/06
DOI: 10.13130/rd_unimi/cmir61/rc6tnp
title: Agosto_1897_Pagina_024.jpg

description: Bulletin of 1897/08/06
DOI: 10.13130/rd_unimi/depg5t/0emytk
title: Agosto_1898_Pagina_005.jpg

description: Bulletin of 1898/08/02
DOI: 10.13130/rd_unimi/depg5t/oxcz5a
title: Agosto_1898_Pagina_006.jpg

description: Bulletin of 1898/08/02
DOI: 10.13130/rd_unimi/cmir61/i52lcb
title: Agosto_1897_Pagina_025.jpg

description: Bulletin of 1897/08/07
DOI: 10.13130/rd_unimi/depg5t/hr4tpm
title: Agosto_1898_Pagina_007.jpg

description: Bulletin of 1898/08/02
DOI: 10.13130/rd_unimi/cmir61/zfyyil
title: Agosto_1897_Pagina_026.jpg

description: Bulletin of 1897/08/07
DOI: 10.13130/rd_unimi/depg5t/apuxgo
title: Agosto_1898_Pagina_008.jpg

description: Bulletin of 1898/08/02
DOI: 10.13130/rd_unimi/cmir61/3yk7wq
title: Agosto_1897_Pagina_027.jpg

description: Bulletin of 1897/08/07
DOI: 10.13130/rd_unimi/cmir61/mgeml7
title: Agosto_1897_Pagina_028.jpg

description: Bulletin of 1897/08/07
DOI: 10.13130/rd_unimi/depg5t/2ol9ye
title: Agosto_1898_Pagina_009.jpg

description: Bulletin of 1898/08/03
DOI: 10.13130/rd_unimi/cmir61/ahevgx
title: Agosto_1897_Pagina_029.jpg

description: Bulletin of 1897/08/08
DOI: 10.13130/rd_unimi/depg5t/chjh3e
title: Agosto_1898_Pagina_010.jpg

description: Bulletin of 1898/08/03
DOI: 10.13130/rd_unimi/cmir61/ecnv8s
title: Agosto_1897_Pagina_030.jpg

description: Bulletin of 1897/08/08
DOI: 10.13130/rd_unimi/depg5t/man9gl
title: Agosto_1898_Pagina_011.jpg

description: Bulletin of 1898/08/03
DOI: 10.13130/rd_unimi/depg5t/o2rqxk
title: Agosto_1898_Pagina_012.jpg

description: Bulletin of 1898/08/03
DOI: 10.13130/rd_unimi/cmir61/djmrwl
title: Agosto_1897_Pagina_032.jpg

description: Bulletin of 1897/08/08
DOI: 10.13130/rd_unimi/cmir61/ldeztk
title: Agosto_1897_Pagina_031.jpg

description: Bulletin of 1897/08/08
DOI: 10.13130/rd_unimi/depg5t/zirqx0
title: Agosto_1898_Pagina_013.jpg

description: Bulletin of 1898/08/04
DOI: 10.13130/rd_unimi/cmir61/9cp2ey
title: Agosto_1897_Pagina_033.jpg

description: Bulletin of 1897/08/09
DOI: 10.13130/rd_unimi/depg5t/afzctb
title: Agosto_1898_Pagina_014.jpg

description: Bulletin of 1898/08/04
DOI: 10.13130/rd_unimi/cmir61/737ifw
title: Agosto_1897_Pagina_034.jpg

description: Bulletin of 1897/08/09
DOI: 10.13130/rd_unimi/depg5t/mo6etp
title: Agosto_1898_Pagina_015.jpg

description: Bulletin of 1898/08/04
DOI: 10.13130/rd_unimi/tdflym/txevcb
title: Agosto_1899_Pagina_001.jpg

description: Bulletin of 1899/08/01
DOI: 10.13130/rd_unimi/cmir61/noaqih
title: Agosto_1897_Pagina_035.jpg

description: Bulletin of 1897/08/09
DOI: 10.13130/rd_unimi/depg5t/emrvn5
title: Agosto_1898_Pagina_016.jpg

description: Bulletin of 1898/08/04
DOI: 10.13130/rd_unimi/tdflym/ejyyhv
title: Agosto_1899_Pagina_002.jpg

description: Bulletin of 1899/08/01
DOI: 10.13130/rd_unimi/cmir61/tu824b
title: Agosto_1897_Pagina_036.jpg

description: Bulletin of 1897/08/09
DOI: 10.13130/rd_unimi/depg5t/bavtn5
title: Agosto_1898_Pagina_017.jpg

description: Bulletin of 1898/08/05
DOI: 10.13130/rd_unimi/tdflym/h1xuvs
title: Agosto_1899_Pagina_003.jpg

description: Bulletin of 1899/08/01
DOI: 10.13130/rd_unimi/cmir61/rdwkuv
title: Agosto_1897_Pagina_037.jpg

description: Bulletin of 1897/08/10
DOI: 10.13130/rd_unimi/depg5t/betxvm
title: Agosto_1898_Pagina_018.jpg

description: Bulletin of 1898/08/05
DOI: 10.13130/rd_unimi/tdflym/o12tbv
title: Agosto_1899_Pagina_004.jpg

description: Bulletin of 1899/08/01
DOI: 10.13130/rd_unimi/cmir61/0zsic6
title: Agosto_1897_Pagina_038.jpg

description: Bulletin of 1897/08/10
DOI: 10.13130/rd_unimi/depg5t/hovv9b
title: Agosto_1898_Pagina_019.jpg

description: Bulletin of 1898/08/05
DOI: 10.13130/rd_unimi/tdflym/sccggj
title: Agosto_1899_Pagina_005.jpg

description: Bulletin of 1899/08/02
DOI: 10.13130/rd_unimi/cmir61/jzxncs
title: Agosto_1897_Pagina_039.jpg

description: Bulletin of 1897/08/10
DOI: 10.13130/rd_unimi/depg5t/5copyu
title: Agosto_1898_Pagina_020.jpg

description: Bulletin of 1898/08/05
DOI: 10.13130/rd_unimi/tdflym/gl9tpd
title: Agosto_1899_Pagina_006.jpg

description: Bulletin of 1899/08/02
DOI: 10.13130/rd_unimi/cmir61/o3v3io
title: Agosto_1897_Pagina_040.jpg

description: Bulletin of 1897/08/10
DOI: 10.13130/rd_unimi/depg5t/39cjp1
title: Agosto_1898_Pagina_021.jpg

description: Bulletin of 1898/08/06
DOI: 10.13130/rd_unimi/cmir61/dhxgrv
title: Agosto_1897_Pagina_041.jpg

description: Bulletin of 1897/08/11
DOI: 10.13130/rd_unimi/depg5t/qtgukd
title: Agosto_1898_Pagina_022.jpg

description: Bulletin of 1898/08/06
DOI: 10.13130/rd_unimi/tdflym/pmbtgd
title: Agosto_1899_Pagina_007.jpg

description: Bulletin of 1899/08/02
DOI: 10.13130/rd_unimi/cmir61/boemj7
title: Agosto_1897_Pagina_042.jpg

description: Bulletin of 1897/08/11
DOI: 10.13130/rd_unimi/depg5t/n0xjzz
title: Agosto_1898_Pagina_023.jpg

description: Bulletin of 1898/08/06
DOI: 10.13130/rd_unimi/tdflym/rniwvm
title: Agosto_1899_Pagina_008.jpg

description: Bulletin of 1899/08/02
DOI: 10.13130/rd_unimi/cmir61/b2yhtf
title: Agosto_1897_Pagina_043.jpg

description: Bulletin of 1897/08/11
DOI: 10.13130/rd_unimi/depg5t/yw2v7k
title: Agosto_1898_Pagina_024.jpg

description: Bulletin of 1898/08/06
DOI: 10.13130/rd_unimi/tdflym/ppwydd
title: Agosto_1899_Pagina_009.jpg

description: Bulletin of 1899/08/03
DOI: 10.13130/rd_unimi/cmir61/ahdq1x
title: Agosto_1897_Pagina_044.jpg

description: Bulletin of 1897/08/11
DOI: 10.13130/rd_unimi/depg5t/8mw75i
title: Agosto_1898_Pagina_025.jpg

description: Bulletin of 1898/08/07
DOI: 10.13130/rd_unimi/tdflym/telzvk
title: Agosto_1899_Pagina_010.jpg

description: Bulletin of 1899/08/03
DOI: 10.13130/rd_unimi/cmir61/lb9iof
title: Agosto_1897_Pagina_045.jpg

description: Bulletin of 1897/08/12
DOI: 10.13130/rd_unimi/depg5t/fkysqy
title: Agosto_1898_Pagina_026.jpg

description: Bulletin of 1898/08/07
DOI: 10.13130/rd_unimi/tdflym/s6gslz
title: Agosto_1899_Pagina_011.jpg

description: Bulletin of 1899/08/03
DOI: 10.13130/rd_unimi/depg5t/lfrug8
title: Agosto_1898_Pagina_027.jpg

description: Bulletin of 1898/08/07
DOI: 10.13130/rd_unimi/tdflym/rhwvis
title: Agosto_1899_Pagina_012.jpg

description: Bulletin of 1899/08/03
DOI: 10.13130/rd_unimi/cmir61/lfruhy
title: Agosto_1897_Pagina_046.jpg

description: Bulletin of 1897/08/12
DOI: 10.13130/rd_unimi/depg5t/zguwes
title: Agosto_1898_Pagina_028.jpg

description: Bulletin of 1898/08/07
DOI: 10.13130/rd_unimi/tdflym/xf1bmf
title: Agosto_1899_Pagina_013.jpg

description: Bulletin of 1899/08/04
DOI: 10.13130/rd_unimi/cmir61/kq2z6t
title: Agosto_1897_Pagina_047.jpg

description: Bulletin of 1897/08/12
DOI: 10.13130/rd_unimi/depg5t/garzio
title: Agosto_1898_Pagina_029.jpg

description: Bulletin of 1898/08/08
DOI: 10.13130/rd_unimi/cmir61/vv4oda
title: Agosto_1897_Pagina_048.jpg

description: Bulletin of 1897/08/12
DOI: 10.13130/rd_unimi/depg5t/xxmgos
title: Agosto_1898_Pagina_030.jpg

description: Bulletin of 1898/08/08
DOI: 10.13130/rd_unimi/tdflym/8vi9jy
title: Agosto_1899_Pagina_014.jpg

description: Bulletin of 1899/08/04
DOI: 10.13130/rd_unimi/cmir61/pshhwu
title: Agosto_1897_Pagina_049.jpg

description: Bulletin of 1897/08/13
DOI: 10.13130/rd_unimi/depg5t/4ctrh1
title: Agosto_1898_Pagina_031.jpg

description: Bulletin of 1898/08/08
DOI: 10.13130/rd_unimi/tdflym/4a1h8f
title: Agosto_1899_Pagina_015.jpg

description: Bulletin of 1899/08/04
DOI: 10.13130/rd_unimi/depg5t/mqf2vx
title: Agosto_1898_Pagina_032.jpg

description: Bulletin of 1898/08/08
DOI: 10.13130/rd_unimi/tdflym/jxdzik
title: Agosto_1899_Pagina_016.jpg

description: Bulletin of 1899/08/04
DOI: 10.13130/rd_unimi/cmir61/2egmwh
title: Agosto_1897_Pagina_050.jpg

description: Bulletin of 1897/08/13
DOI: 10.13130/rd_unimi/depg5t/sn0ljn
title: Agosto_1898_Pagina_033.jpg

description: Bulletin of 1898/08/09
DOI: 10.13130/rd_unimi/tdflym/dxjmw0
title: Agosto_1899_Pagina_017.jpg

description: Bulletin of 1899/08/05
DOI: 10.13130/rd_unimi/cmir61/smejlr
title: Agosto_1897_Pagina_051.jpg

description: Bulletin of 1897/08/13
DOI: 10.13130/rd_unimi/cmir61/pkxycn
title: Agosto_1897_Pagina_052.jpg

description: Bulletin of 1897/08/13
DOI: 10.13130/rd_unimi/depg5t/by3bjd
title: Agosto_1898_Pagina_034.jpg

description: Bulletin of 1898/08/09
DOI: 10.13130/rd_unimi/tdflym/5jg3ao
title: Agosto_1899_Pagina_018.jpg

description: Bulletin of 1899/08/05
DOI: 10.13130/rd_unimi/depg5t/nppuw5
title: Agosto_1898_Pagina_035.jpg

description: Bulletin of 1898/08/09
DOI: 10.13130/rd_unimi/tdflym/aeglzy
title: Agosto_1899_Pagina_019.jpg

description: Bulletin of 1899/08/05
DOI: 10.13130/rd_unimi/cmir61/fxhs43
title: Agosto_1897_Pagina_053.jpg

description: Bulletin of 1897/08/14
DOI: 10.13130/rd_unimi/tdflym/nylimu
title: Agosto_1899_Pagina_020.jpg

description: Bulletin of 1899/08/05
DOI: 10.13130/rd_unimi/depg5t/cmtanx
title: Agosto_1898_Pagina_036.jpg

description: Bulletin of 1898/08/09
DOI: 10.13130/rd_unimi/tdflym/b1rucz
title: Agosto_1899_Pagina_021.jpg

description: Bulletin of 1899/08/06
DOI: 10.13130/rd_unimi/cmir61/zdjly6
title: Agosto_1897_Pagina_054.jpg

description: Bulletin of 1897/08/14
DOI: 10.13130/rd_unimi/depg5t/wkrs1x
title: Agosto_1898_Pagina_037.jpg

description: Bulletin of 1898/08/10
DOI: 10.13130/rd_unimi/cmir61/ckxywx
title: Agosto_1897_Pagina_055.jpg

description: Bulletin of 1897/08/14
DOI: 10.13130/rd_unimi/depg5t/v7ppja
title: Agosto_1898_Pagina_038.jpg

description: Bulletin of 1898/08/10
DOI: 10.13130/rd_unimi/gwa1r1/inhyg6
title: Agosto_1901_Pagina_001.jpg

description: Bulletin of 1901/08/01
DOI: 10.13130/rd_unimi/tdflym/etydhy
title: Agosto_1899_Pagina_022.jpg

description: Bulletin of 1899/08/06
DOI: 10.15151/esrf-es-2234399420
title: The Iberian cryoEM community BAG (III)

description: The Iberian cryoEM BAG is a consortium of approximately 40 research groups from Portugal and Spain, focused on addressing critical biological questions. These include studies on membrane proteins, disease-related metabolic enzymes, antibiotic resistance, DNA replication and maintenance, protein synthesis, viral structure and replication mechanisms, and macromolecular complexes involved in key cellular processes such as protein folding and degradation. For these groups, electron cryo-microscopy is an indispensable tool, and access to ESRF resources is vital for advancing their research and achieving impactful results.
DOI: 10.13130/rd_unimi/gwa1r1/9dyycg
title: Agosto_1901_Pagina_002.jpg

description: Bulletin of 1901/08/01
DOI: 10.13130/rd_unimi/tdflym/tvybea
title: Agosto_1899_Pagina_023.jpg

description: Bulletin of 1899/08/06
DOI: 10.13130/rd_unimi/cmir61/ga3522
title: Agosto_1897_Pagina_056.jpg

description: Bulletin of 1897/08/14
DOI: 10.13130/rd_unimi/depg5t/fowekc
title: Agosto_1898_Pagina_039.jpg

description: Bulletin of 1898/08/10
DOI: 10.13130/rd_unimi/depg5t/ynzdbj
title: Agosto_1898_Pagina_040.jpg

description: Bulletin of 1898/08/10
DOI: 10.13130/rd_unimi/gwa1r1/mderqu
title: Agosto_1901_Pagina_003.jpg

description: Bulletin of 1901/08/01
DOI: 10.13130/rd_unimi/tdflym/u23ydb
title: Agosto_1899_Pagina_024.jpg

description: Bulletin of 1899/08/06
DOI: 10.13130/rd_unimi/cmir61/dbrmxd
title: Agosto_1897_Pagina_057.jpg

description: Bulletin of 1897/08/15
DOI: 10.13130/rd_unimi/cmir61/prjorn
title: Agosto_1897_Pagina_058.jpg

description: Bulletin of 1897/08/15
DOI: 10.13130/rd_unimi/depg5t/hxfdhq
title: Agosto_1898_Pagina_041.jpg

description: Bulletin of 1898/08/11
DOI: 10.13130/rd_unimi/gwa1r1/87u8zd
title: Agosto_1901_Pagina_004.jpg

description: Bulletin of 1901/08/01
DOI: 10.13130/rd_unimi/tdflym/gls3vc
title: Agosto_1899_Pagina_025.jpg

description: Bulletin of 1899/08/07
DOI: 10.13130/rd_unimi/depg5t/jamtag
title: Agosto_1898_Pagina_042.jpg

description: Bulletin of 1898/08/11
DOI: 10.13130/rd_unimi/gwa1r1/wrpdif
title: Agosto_1901_Pagina_005.jpg

description: Bulletin of 1901/08/02
DOI: 10.13130/rd_unimi/tdflym/citcpa
title: Agosto_1899_Pagina_026.jpg

description: Bulletin of 1899/08/07
DOI: 10.13130/rd_unimi/cmir61/jmnd8n
title: Agosto_1897_Pagina_059.jpg

description: Bulletin of 1897/08/15
DOI: 10.13130/rd_unimi/gwa1r1/6dzuti
title: Agosto_1901_Pagina_006.jpg

description: Bulletin of 1901/08/02
DOI: 10.6084/m9.figshare.30901509
title: Thymosin α 1 potentiates the release by CD8<sup>+</sup> cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection <i>in vitro</i>

description: <b><i>Background:</i></b> Thymosin α-1 (Tα1) exploits a specific action on lymphoid cells and is able to induce in peripheral blood mononuclear cells (PBMCs) a strong transcriptional response. CD8 antiviral factor activity plays a role in the control or prevention of HIV-1 infection by a non-cytolytic mechanism. The ability of Tα1 to modulate the release of antiretroviral soluble factors by CD8<sup>+</sup> cells was investigated. <b><i>Methods:</i></b> Supernatants from lipopolysaccharide (LPS) stimulated CD8<sup>+</sup>-isolated cells treated with Tα1 were screened on <i>in vitro</i> infection of human monocyte-derived macrophages (MDMs) and PBMCs with HIV-1, and of PBMCs with human T lymphotropic virus 1 (HTLV-1). In CD8<sup>+</sup> cells, as well as in PBMCs of healthy donors as from HIV<sup>+</sup> individuals, a microarray analysis to assess the transcriptional response after treatment was performed. <b><i>Results:</i></b> Tα1 potentiates the release, in LPS-stimulated CD8<sup>+</sup> cells, of soluble factors able to inhibit both <i>in vitro</i> HIV-1 infection of MDMs and PBMCs and <i>in vitro</i> HTLV-1 infection of PBMCs. A distinctive transcriptional profile was induced by Tα1 in PBMCs from HIV<sup>+</sup> donors. <b><i>Conclusions:</i></b> These findings suggest that Tα1 would represent a re-evaluated approach to antiretroviral therapy in combination with innovative treatments and with vaccine administration.
DOI: 10.13130/rd_unimi/depg5t/afv1zv
title: Agosto_1898_Pagina_043.jpg

description: Bulletin of 1898/08/11
DOI: 10.13130/rd_unimi/gwa1r1/alyoe7
title: Agosto_1901_Pagina_007.jpg

description: Bulletin of 1901/08/02
DOI: 10.13130/rd_unimi/tdflym/uqhiku
title: Agosto_1899_Pagina_027.jpg

description: Bulletin of 1899/08/07
DOI: 10.6084/m9.figshare.30901509.v1
title: Thymosin α 1 potentiates the release by CD8<sup>+</sup> cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection <i>in vitro</i>

description: <b><i>Background:</i></b> Thymosin α-1 (Tα1) exploits a specific action on lymphoid cells and is able to induce in peripheral blood mononuclear cells (PBMCs) a strong transcriptional response. CD8 antiviral factor activity plays a role in the control or prevention of HIV-1 infection by a non-cytolytic mechanism. The ability of Tα1 to modulate the release of antiretroviral soluble factors by CD8<sup>+</sup> cells was investigated. <b><i>Methods:</i></b> Supernatants from lipopolysaccharide (LPS) stimulated CD8<sup>+</sup>-isolated cells treated with Tα1 were screened on <i>in vitro</i> infection of human monocyte-derived macrophages (MDMs) and PBMCs with HIV-1, and of PBMCs with human T lymphotropic virus 1 (HTLV-1). In CD8<sup>+</sup> cells, as well as in PBMCs of healthy donors as from HIV<sup>+</sup> individuals, a microarray analysis to assess the transcriptional response after treatment was performed. <b><i>Results:</i></b> Tα1 potentiates the release, in LPS-stimulated CD8<sup>+</sup> cells, of soluble factors able to inhibit both <i>in vitro</i> HIV-1 infection of MDMs and PBMCs and <i>in vitro</i> HTLV-1 infection of PBMCs. A distinctive transcriptional profile was induced by Tα1 in PBMCs from HIV<sup>+</sup> donors. <b><i>Conclusions:</i></b> These findings suggest that Tα1 would represent a re-evaluated approach to antiretroviral therapy in combination with innovative treatments and with vaccine administration.
DOI: 10.13130/rd_unimi/cmir61/nz7pzw
title: Agosto_1897_Pagina_060.jpg

description: Bulletin of 1897/08/15
DOI: 10.13130/rd_unimi/depg5t/qufmjf
title: Agosto_1898_Pagina_044.jpg

description: Bulletin of 1898/08/11
DOI: 10.13130/rd_unimi/tdflym/zmkjic
title: Agosto_1899_Pagina_028.jpg

description: Bulletin of 1899/08/07
DOI: 10.13130/rd_unimi/cmir61/fcn0ud
title: Agosto_1897_Pagina_061.jpg

description: Bulletin of 1897/08/16
DOI: 10.13130/rd_unimi/gwa1r1/qfiie1
title: Agosto_1901_Pagina_008.jpg

description: Bulletin of 1901/08/02
DOI: 10.15151/esrf-es-2267526619
title: Direct Observation of Structural Dynamics in the Dimerization of DNA Base Pairs via Time-Resolved X-ray Solution Scattering

description: The UV-induced formation of lesions in DNA has intrigued scientists since its first observation in 1958. Thymine (T), cytosine (C), and uracil (U) undergo photodimerization upon UV irradiation, disrupting complementary bonds and damaging the double helix. While this process follows a [2+2] cycloaddition, its kinetics and mechanism remain debated. Here, we investigate the structural dynamics of UV-induced dimerization in solvated pyrimidine nucleobases using time-resolved X-ray liquidography (TRXL). As no structure-sensitive probe has directly captured this process, our study will offer unprecedented insights into nucleobase evolution before and during photodimerization, advancing our understanding of DNA lesion formation and repair.
DOI: 10.13130/rd_unimi/depg5t/cux9yo
title: Agosto_1898_Pagina_045.jpg

description: Bulletin of 1898/08/12
DOI: 10.13130/rd_unimi/tdflym/rqo9nh
title: Agosto_1899_Pagina_029.jpg

description: Bulletin of 1899/08/08
DOI: 10.13130/rd_unimi/cmir61/5jls6j
title: Agosto_1897_Pagina_062.jpg

description: Bulletin of 1897/08/16
DOI: 10.13130/rd_unimi/depg5t/wsv2fd
title: Agosto_1898_Pagina_046.jpg

description: Bulletin of 1898/08/12
DOI: 10.13130/rd_unimi/gwa1r1/cp5oel
title: Agosto_1901_Pagina_009.jpg

description: Bulletin of 1901/08/03
DOI: 10.13130/rd_unimi/tdflym/gdw7gh
title: Agosto_1899_Pagina_030.jpg

description: Bulletin of 1899/08/08
DOI: 10.6084/m9.figshare.30901626
title: Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages

description: <b><i>Background and aims:</i></b> The immunomodulatory activity of thymosin α1 (Tα1) on innate immunity has been extensively described, but its mechanism of action is not completely understood. We explored the possibility that Tα1-stimulation could affect the formation of podosomes, the highly dynamic, actin-rich, adhesion structures involved in macrophage adhesion/chemotaxis. <b><i>Methods:</i></b> The following methods were used: optical and scanning electron microscopy for analyzing morphology of human monocyte-derived macrophages (MDMs); time-lapse imaging for visualizing the time-dependent modifications induced at early times by Tα1 treatment; confocal microscopy and Western blot for analyzing localization and expression of podosome components; and Matrigel Migration Assay and zymography for testing MDM invasive ability and metalloproteinase secretion. <b><i>Results:</i></b> We obtained data to support that Tα1 could affect MDM motility, invasion and chemotaxis by promptly stimulating assembly and disassembly of podosomal structures. At very early times after its addition to cell culture medium and within 1 h of treatment, Tα1 induces modifications in MDM morphology and in podosomal components that are suggestive of increased podosome turnover. <b><i>Conclusions:</i></b> Since impairment of podosome formation leads to reduced innate immunity and is associated with several immunodeficiency disorders, we confirm the validity of Tα1 as a potent activator of innate immunity and suggest possible new clinical application of this thymic peptide.
DOI: 10.6084/m9.figshare.30901626.v1
title: Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages

description: <b><i>Background and aims:</i></b> The immunomodulatory activity of thymosin α1 (Tα1) on innate immunity has been extensively described, but its mechanism of action is not completely understood. We explored the possibility that Tα1-stimulation could affect the formation of podosomes, the highly dynamic, actin-rich, adhesion structures involved in macrophage adhesion/chemotaxis. <b><i>Methods:</i></b> The following methods were used: optical and scanning electron microscopy for analyzing morphology of human monocyte-derived macrophages (MDMs); time-lapse imaging for visualizing the time-dependent modifications induced at early times by Tα1 treatment; confocal microscopy and Western blot for analyzing localization and expression of podosome components; and Matrigel Migration Assay and zymography for testing MDM invasive ability and metalloproteinase secretion. <b><i>Results:</i></b> We obtained data to support that Tα1 could affect MDM motility, invasion and chemotaxis by promptly stimulating assembly and disassembly of podosomal structures. At very early times after its addition to cell culture medium and within 1 h of treatment, Tα1 induces modifications in MDM morphology and in podosomal components that are suggestive of increased podosome turnover. <b><i>Conclusions:</i></b> Since impairment of podosome formation leads to reduced innate immunity and is associated with several immunodeficiency disorders, we confirm the validity of Tα1 as a potent activator of innate immunity and suggest possible new clinical application of this thymic peptide.
DOI: 10.13130/rd_unimi/gwa1r1/tattyu
title: Agosto_1901_Pagina_010.jpg

description: Bulletin of 1901/08/03
DOI: 10.13130/rd_unimi/tdflym/botuip
title: Agosto_1899_Pagina_031.jpg

description: Bulletin of 1899/08/08
DOI: 10.13130/rd_unimi/cmir61/3asr2c
title: Agosto_1897_Pagina_063.jpg

description: Bulletin of 1897/08/16