cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.29900177.v1
title: Supplementary Material for: Safety and Efficacy of Givinostat for patients with Muscular dystrophy: A Systematic review

description: Introduction: Muscular dystrophy(MD) refers to a group of genetic disorders leading to progressive weakness and degeneration of skeletal muscle. Among them, Duchenne muscular dystrophy(DMD) and Becker muscular dystrophy(BMD) are the most common types. Histone deacetylase(HDAC) inhibitors(i.e. Givinostat) are a recently approved therapy for DMD. In this systematic review, we aim to evaluate Givinostat in MD patients regarding safety and efficacy.
Methods: A systematic review was performed according to the PRISMA guidelines by searching through Medline, Embase, Cochrane Library and Web of Science. Only RCT comparing Givinostat vs placebo or other therapies are included. The primary outcomes were motor function alteration and histopathologic muscle changes and the secondary outcomes were the adverse reactions.
Results: A total of 188 records were identified, and after screening, two clinical trials met the inclusion criteria. In DMD patients, Givinostat significantly slowed disease progression, improving four stair-climb times (p=0.037) and reducing muscle fat infiltration. In BMD patients, fibrosis progression was not significantly different (p=0.8282), but MRI showed reduced muscle fat replacement. Common adverse events included diarrhea, thrombocytopenia, and hypertriglyceridemia, leading to dose reductions, though no new safety signals or treatment-related deaths were observed.
Discussion: Givinostat seems to be effective in slowing disease progression in DMD but has little benefit in BMD. Its safety profile requires rigorous monitoring. Efficacy difference might be explained by the pathophysiology of the disease and the progression rate. Larger and longer follow-up trials are warranted to confirm longer term benefits and to optimize dosing strategies.
Conclusion: Givinostat offers potential as a disease-modifying therapy for DMD but requires further investigation to establish its role in BMD.
DOI: 10.3535/1gn-r38-xf9
title: Eobania vermiculata (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/p4w-nz9-rlp
title: Arianta arbustorum (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4f9-d0m-gz1
title: Lamarcka ventricosa (Lamarck, 1819)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5vt-e6b-rqz
title: Lamarcka avellana (Lamarck, 1819)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5xd-t06-ddx
title: Lissachatina fulica (Bowdich, 1822)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vs6-zvn-20e
title: Codakia tigerina (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g1t-ym4-lc5
title: Unionidae Rafinesque, 1820

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/885-nww-tme
title: Annachlamys flabellata (Lamarck, 1819)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/vhn-vtt-9mm
title: Spondylus nicobaricus Schreibers, 1793

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fwr-b7v-ez8
title: Malleus malleus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kpl-23h-7tt
title: Modiolus modiolus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/al4-nvg-ejs
title: Spondylus squamosus Schreibers, 1793

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4zc-wa7-49x
title: Xesta citrina (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/kdv-r5d-ccp
title: Calocochlea zonifera (L. Pfeiffer, 1842)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/8g5-qz2-n8t
title: Eucobresia diaphana (Draparnaud, 1805)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/9cf-rwd-0y0
title: Miradiscops H. B. Baker, 1925

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/4wc-0gx-ty6
title: Utterbackia imbecillis (Say, 1829)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qlw-exp-vcy
title: Unionidae Rafinesque, 1820

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/zwm-ra7-9j5
title: Amphidromus inversus andamensis (L. Pfeiffer, 1871)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/c1y-sqe-m0a
title: Conus ebraeus Linnaeus, 1758

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/fsg-zjr-bsv
title: Euomphalia strigella (Draparnaud, 1801)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g8p-xe4-7rq
title: Argopecten gibbus (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g0s-8t6-lw7
title: Eobania vermiculata (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/p0s-bqx-3zr
title: Conus distans Hwass, 1792

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.fzpcw9
title: Occurrence Download

description: A dataset containing 5452 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Nymphaea marliacea"
 ]
}

 The dataset includes 5452 records from 47 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004919-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/77x-1t5-t3y
title: Obba reeveana (L. Pfeiffer, 1846)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rda-afr-a9w
title: Zonitidae Mörch, 1864

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/qjz-wkd-786
title: Theba pisana (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/5cz-xbn-9vb
title: Cepaea nemoralis (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/rct-fmv-dqd
title: Barbatia domingensis (Lamarck, 1819)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.15468/dl.m9vprg
title: Occurrence Download

description: A dataset containing 8507 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Coracias garrulus",
 "MediaType is Image"
 ]
}

 The dataset includes 8507 records from 35 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0004918-250811113504898/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/0xr-yc0-j1y
title: Cochlicella acuta (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/wqt-v04-53v
title: Helicigona lapicida (Linnaeus, 1758)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/b7p-2q8-b9s
title: Theba pisana (O. F. Müller, 1774)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/g0j-azt-zhb
title: Vitrinula bocki (E. A. Smith, 1887)

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/lsl-n8z-ljk
title: Xesta Albers, 1850

description: Digital Specimen for the physical specimen hosted at Naturalis Biodiversity Center.
DOI: 10.3535/01q-bv2-qgk
title: Ramalina

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/f3f-95m-z2l
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/a1s-1x5-k0t
title: Ramalina

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/mc4-3rd-lh8
title: Isoglossa perplexa (T. F. Daniel, Letsara & Martín-Bravo) I. Darbysh. & Kiel

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/cax-fbk-yyn
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bwg-44t-ss6
title: Ramalina

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/pm0-bmf-lc9
title: Taraxacum Weber

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/sgw-sx0-vg8
title: Ramalina

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/sws-a75-9gw
title: Ramalina fraxinea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/5ax-11s-15j
title: Ramalina

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.3wdnru
title: Occurrence Download

description: A dataset containing 8 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Tetropium velutinum LeConte, 1869",
 "Year is less than or equal to 2024"
 ]
}

 The dataset includes 8 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112676-250525065834625/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.3535/cqk-qpk-647
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/njz-rjp-n0j
title: Pseuderanthemum campylosiphon Mildbr.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/h8g-t7n-rlj
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/saj-1w5-z4z
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/awq-qvl-q4z
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/fhr-t3z-e50
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/52t-wbm-mh0
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ye8-f2h-jsv
title: Carpesium abrotanoides L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/j87-4r1-1mq
title: Libinhania sphaerocephala (Balf. fil.) N. Kilian, Galbany, Oberpr. & A. G. Mill.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/0p9-k6p-wev
title: Erysimum kurdicum Boiss. & Hausskn.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/r9l-97r-jql
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/56j-xmx-1r4
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hx1-d0a-nbz
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/78l-er5-7fr
title: Poa sinaica Steud.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/89v-lax-81h
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/w6c-9rm-8pw
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/bdt-ewk-cmr
title: Helichrysum somalense Baker fil.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/qsj-s85-hhv
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/76m-pxj-wns
title: Ramalina calicaris (L.) Röhl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/jr8-7cj-yq7
title: Zephyranthes laeta (Phil.) Nic.García

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/959-3bd-mjl
title: Ramalina calicaris (L.) Röhl.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/tkr-l5k-7vl
title: Campanula lyrata Lam.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/3tz-l6b-dyf
title: Myrsine coriacea subsp. coriacea

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hjw-1pl-eqe
title: Anthemis pedunculata subsp. pedunculata

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/hvf-vnw-gx9
title: Ramalina farinacea (L.) Ach.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/5tf-wqy-al7
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/a48-hvj-ky4
title: Poa maroccana Nannf.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/38s-y27-b8n
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/h4r-g8h-fbg
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15468/dl.239e7h
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Casuarina glauca Sieber",
 "Country is Bahamas",
 "HasCoordinate is true"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0112677-250525065834625/datasets/export for details.
DOI: 10.3535/bxc-0ct-w2f
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/ene-0ay-mg8
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/vy6-nl4-hw8
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/6d7-q46-cw7
title: Libinhania nivea A. G. Mill., Sommerer & N. Kilian

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/fxp-k7g-7n8
title: Nigella damascena L.

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/b0v-fp2-zr7
title: Senega lancifolia (A. St.-Hil. & Moq.) J. F. B. Pastore

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/86d-efd-lha
title: Taraxacum fragosum Sonck

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.3535/tbv-yyb-nl5
title: Pinus uncinata subsp. uncinata

description: Digital Specimen for the physical specimen hosted at Botanic Garden and Botanical Museum Berlin.
DOI: 10.15156/bio/sh0167257.10fu
title: SH0167257.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0167258.10fu
title: SH0167258.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0167259.10fu
title: SH0167259.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0167260.10fu
title: SH0167260.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
DOI: 10.15156/bio/sh0167261.10fu
title: SH0167261.10FU

description: UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.