cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.22785420.v1
title: Crohn’s disease: review and standardization of nomenclature

description: Abstract Crohn’s disease is an inflammatory bowel disease that can affect any segment of the gastrointestinal tract. It has a variable clinical course, with alternating periods of disease activity and remission. Because the incidence and prevalence of Crohn’s disease have been increasing, evaluation by imaging methods has become more important. The most widely used methods are computed tomography enterography, magnetic resonance enterography (as an elective examination), and contrast-enhanced computed tomography (in the context of emergency). Computed tomography enterography and magnetic resonance enterography are useful for diagnosis, follow-up, evaluation of complications, and prognosis. Both can be used in order to evaluate the small bowel loops and the associated mesenteric findings, as well as to evaluate other abdominal organs. They both also can detect signs of disease activity, fibrosis, penetrating disease, and complications. The interpretation of such changes is essential to the multidisciplinary approach, as is the standardization of the nomenclature employed in the reports. In this paper, we review and illustrate the imaging findings of Crohn’s disease, using the standardized nomenclature proposed in the multidisciplinary consensus statement issued by the Society of Abdominal Radiology, the Society of Pediatric Radiology, and the American Gastroenterology Association, with recommendations for descriptions, interpretations, and impressions related to those findings.
DOI: 10.6084/m9.figshare.22778903
title: Data from: Legume effects in a native community invaded by alien Asteraceae in a multi-species comparison

description: The data files “Ferenc_et_al_2023_Data1.csv”, “Ferenc_et_al_2023_Data2.csv”, “Ferenc_et_al_2023_Data3.csv”, “Ferenc_et_al_2023_Data4.csv” contain data which was collected from a common garden experiment at a field station of the University of Hohenheim (48°42’45.2”N, 9°11’23.6”E) in Stuttgart, Germany, during the growing season 2016.
DOI: 10.6084/m9.figshare.22778903.v2
title: Data from: Legume effects in a native community invaded by alien Asteraceae in a multi-species comparison

description: The data files “Ferenc_et_al_2023_Data1.csv”, “Ferenc_et_al_2023_Data2.csv”, “Ferenc_et_al_2023_Data3.csv”, “Ferenc_et_al_2023_Data4.csv” contain data which was collected from a common garden experiment at a field station of the University of Hohenheim (48°42’45.2”N, 9°11’23.6”E) in Stuttgart, Germany, during the growing season 2016.
DOI: 10.6084/m9.figshare.22778903.v1
title: Data from: Legume effects in a native community invaded by alien Asteraceae in a multi-species comparison

description: The data files “Ferenc_et_al_2023_Data1.csv”, “Ferenc_et_al_2023_Data2.csv”, “Ferenc_et_al_2023_Data3.csv”, “Ferenc_et_al_2023_Data4.csv” contain data which was collected from a common garden experiment at a field station of the University of Hohenheim (48°42’45.2”N, 9°11’23.6”E) in Stuttgart, Germany, during the growing season 2016.
DOI: 10.6084/m9.figshare.22785421
title: Cytotoxicity evaluation of haloperidol, clozapine and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells

description: Abstract Schizophrenia is an illness that affects 26 million people worldwide. However, conventional antipsychotics present side effects and toxicity, highlighting the need for new antipsychotics. We aimed to evaluate the cytotoxicity of haloperidol (HAL), clozapine (CLO), and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells. The neutral red uptake assay and the MTT assay were performed to evaluate cell viability and mitochondrial activity, morphological changes were assessed, and intracellular reactive oxygen species (ROS) detection was performed. HAL and CLO (0.1 μM) showed a decrease in cell viability in the neutral red uptake assay and in the MTT assay. In addition, cell detachment, content decrease, rounding and cell death were also observed at 0.1 μM for both antipsychotics. An increase in ROS was observed for HAL (0.001, 0.01 and 1 μM) and CLO (0.01 and 1 μM). PT-31 did not alter cell viability in any of the assays, although it increased ROS at 0.01 and 1 μM. HAL and CLO present cytotoxicity at 0.1 μM, possibly through apoptosis and necrosis. In contrast, PT-31 does not present cytotoxicity to NIH-3T3 cells. Further studies must be performed for a better understanding of these mechanisms and the potential risk of conventional antipsychotics.
DOI: 10.6084/m9.figshare.22785421.v1
title: Cytotoxicity evaluation of haloperidol, clozapine and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells

description: Abstract Schizophrenia is an illness that affects 26 million people worldwide. However, conventional antipsychotics present side effects and toxicity, highlighting the need for new antipsychotics. We aimed to evaluate the cytotoxicity of haloperidol (HAL), clozapine (CLO), and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells. The neutral red uptake assay and the MTT assay were performed to evaluate cell viability and mitochondrial activity, morphological changes were assessed, and intracellular reactive oxygen species (ROS) detection was performed. HAL and CLO (0.1 μM) showed a decrease in cell viability in the neutral red uptake assay and in the MTT assay. In addition, cell detachment, content decrease, rounding and cell death were also observed at 0.1 μM for both antipsychotics. An increase in ROS was observed for HAL (0.001, 0.01 and 1 μM) and CLO (0.01 and 1 μM). PT-31 did not alter cell viability in any of the assays, although it increased ROS at 0.01 and 1 μM. HAL and CLO present cytotoxicity at 0.1 μM, possibly through apoptosis and necrosis. In contrast, PT-31 does not present cytotoxicity to NIH-3T3 cells. Further studies must be performed for a better understanding of these mechanisms and the potential risk of conventional antipsychotics.
DOI: 10.6084/m9.figshare.22785423
title: Optimizing stiffness and lightweight design of composite monocoque sandwich structure for electric heavy quadricycle

description: Abstract The lightweight design of electric heavy quadricycle (L7e) vehicles has contributed to energy savings and sustainable mobility. This study proposes an optimization methodology to design a monocoque sandwich structure under operating conditions for an L7e using a finite element model via HyperWorks. Woven fiberglass fabrics and high-density PVC foam are assigned as the face and core to construct the sandwich structure, respectively. Free-size optimization based on weight minimization is applied to obtain the suitable initial thickness of face and core structures in all components. Multi-objective size optimization is then performed by minimizing both mass and material cost to determine the optimal thickness of each layer. Finally, shuffle optimization is used to modify the stacking sequence for each component to maximize structural stiffness. The results indicate that the core thickness in the passenger compartment is sufficient to maintain stiffness while maintaining the structure's lightweight. However, shuffle optimization is insignificant for the current monocoque model, as the structural stiffness is only marginally improved after the process. Additionally, this study examines the optimized models for structural stiffness and discusses suitable procedures for designing a lightweight and safe electric vehicle.
DOI: 10.6084/m9.figshare.22785423.v1
title: Optimizing stiffness and lightweight design of composite monocoque sandwich structure for electric heavy quadricycle

description: Abstract The lightweight design of electric heavy quadricycle (L7e) vehicles has contributed to energy savings and sustainable mobility. This study proposes an optimization methodology to design a monocoque sandwich structure under operating conditions for an L7e using a finite element model via HyperWorks. Woven fiberglass fabrics and high-density PVC foam are assigned as the face and core to construct the sandwich structure, respectively. Free-size optimization based on weight minimization is applied to obtain the suitable initial thickness of face and core structures in all components. Multi-objective size optimization is then performed by minimizing both mass and material cost to determine the optimal thickness of each layer. Finally, shuffle optimization is used to modify the stacking sequence for each component to maximize structural stiffness. The results indicate that the core thickness in the passenger compartment is sufficient to maintain stiffness while maintaining the structure's lightweight. However, shuffle optimization is insignificant for the current monocoque model, as the structural stiffness is only marginally improved after the process. Additionally, this study examines the optimized models for structural stiffness and discusses suitable procedures for designing a lightweight and safe electric vehicle.
DOI: 10.6084/m9.figshare.22785426
title: Determining indicator plant species of Pinus brutia Ten. Site index classes using interspecific correlation analysis in Antalya (Turkey)

description: ABSTRACT Background: We performed a vegetation study in Antalya, where the Mediterranean climate prevails, in order to determine the indicator plant species of red pine (Pinus brutia Ten.). Red pine can be widely distributed from sea level to 1200 meters. Its main distribution is in the main Mediterranean vegetation zone between 500-1000 meters. However, the variation of the habitat factors may be low in this range. Therefore, the productivity relationships of species such as red pine, whose sustainable use is important, cannot be directly explained by environmental variables. In such cases, it is important to determine the indicator plant species. For this reason, indicator plant species of red pine productivity (site index class I) were determined by using interspecific correlation analysis (ICA) in the study. Then, using principal components analysis, the relationship of indicator plant species with the variables of elevation, slope, aspect and soil depth was revealed. In the principal components analysis, the plant species that were determined as an indicator were also added to the graph as a class variable, and the effects of the variables on the indicator plant species were also investigated. Results: The results of the ICA showed that Dryopteris flix-mas (L.) Schott, Abies cilicica (Antoine & Kotschy) Carrière, Cedrus libani A. RICH and Colutea cilicica Boiss. & Bal. species were negative indicators of red pine productivity. On the other hand, Cistus creticus L. and Smilax aspera L. species were positive indicators of productivity Conclusions: Interspecific correlation analysis is a useful tool to determine the ecological properties of species that have a local distribution or a vertical distribution in a narrow altitude range. It also offers practical and effective results, especially for species with high commercial value such as red pine.
DOI: 10.6084/m9.figshare.22785426.v1
title: Determining indicator plant species of Pinus brutia Ten. Site index classes using interspecific correlation analysis in Antalya (Turkey)

description: ABSTRACT Background: We performed a vegetation study in Antalya, where the Mediterranean climate prevails, in order to determine the indicator plant species of red pine (Pinus brutia Ten.). Red pine can be widely distributed from sea level to 1200 meters. Its main distribution is in the main Mediterranean vegetation zone between 500-1000 meters. However, the variation of the habitat factors may be low in this range. Therefore, the productivity relationships of species such as red pine, whose sustainable use is important, cannot be directly explained by environmental variables. In such cases, it is important to determine the indicator plant species. For this reason, indicator plant species of red pine productivity (site index class I) were determined by using interspecific correlation analysis (ICA) in the study. Then, using principal components analysis, the relationship of indicator plant species with the variables of elevation, slope, aspect and soil depth was revealed. In the principal components analysis, the plant species that were determined as an indicator were also added to the graph as a class variable, and the effects of the variables on the indicator plant species were also investigated. Results: The results of the ICA showed that Dryopteris flix-mas (L.) Schott, Abies cilicica (Antoine & Kotschy) Carrière, Cedrus libani A. RICH and Colutea cilicica Boiss. & Bal. species were negative indicators of red pine productivity. On the other hand, Cistus creticus L. and Smilax aspera L. species were positive indicators of productivity Conclusions: Interspecific correlation analysis is a useful tool to determine the ecological properties of species that have a local distribution or a vertical distribution in a narrow altitude range. It also offers practical and effective results, especially for species with high commercial value such as red pine.
DOI: 10.6084/m9.figshare.22785430
title: Interactive gerontechnology for fall prevention in the elderly: a descriptive study

description: ABSTRACT Objectives: to develop interactive gerontechnology for the prevention of falls in the elderly at home. Methods: an exploratory and descriptive study that consisted of gerontechnology development and evaluation by experts and the target audience. For evaluation, researchers used the Agreement Index (AI), considering values greater than 80%. Results: the three-dimensional virtual scale model was elaborated through the SketchUp program, with the distribution of rooms and floors, constituting Prototype 1 (P1). Fifty-four judges evaluated the P1, and all presented agreement above the established, with a minimum AI of 88% and a maximum of 100%, producing Prototype 2 (P2). Thirty elderly participants from a philanthropic institution evaluated Prototype 2. On all items, AI ranged from 83% a 100%, resulting in the final version. Conclusions: the product of this research reveals itself as an innovative and scientifically based tool aimed at preventing falls in the elderly.
DOI: 10.6084/m9.figshare.22785430.v1
title: Interactive gerontechnology for fall prevention in the elderly: a descriptive study

description: ABSTRACT Objectives: to develop interactive gerontechnology for the prevention of falls in the elderly at home. Methods: an exploratory and descriptive study that consisted of gerontechnology development and evaluation by experts and the target audience. For evaluation, researchers used the Agreement Index (AI), considering values greater than 80%. Results: the three-dimensional virtual scale model was elaborated through the SketchUp program, with the distribution of rooms and floors, constituting Prototype 1 (P1). Fifty-four judges evaluated the P1, and all presented agreement above the established, with a minimum AI of 88% and a maximum of 100%, producing Prototype 2 (P2). Thirty elderly participants from a philanthropic institution evaluated Prototype 2. On all items, AI ranged from 83% a 100%, resulting in the final version. Conclusions: the product of this research reveals itself as an innovative and scientifically based tool aimed at preventing falls in the elderly.
DOI: 10.5281/zenodo.7554914
title: orthosData

description: `<strong>orthosData</strong>` is the companion database to the `<strong>orthos</strong>` software for mechanistic studies using differential gene expression experiments. It currently encompasses data for over 100,000 differential gene expression mouse and human experiments distilled and compiled from the ARCHS4 database* as well as associated pre-trained variational models. Together with `<strong>orthos</strong>` it was developed to provide a better understanding of the effects of experimental treatments on gene expression and to help map treatments to mechanisms of action.
description: *Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Wang L, Silverstein MC, Ma'ayan A. Massive mining of publicly available RNA-seq data from human and mouse. Nature Communications 9. Article number: 1366 (2018), doi:10.1038/s41467-018-03751-6
DOI: 10.5281/zenodo.7554915
title: orthosData

description: `<strong>orthosData</strong>` is the companion database to the `<strong>orthos</strong>` software for mechanistic studies using differential gene expression experiments. It currently encompasses data for over 100,000 differential gene expression mouse and human experiments distilled and compiled from the ARCHS4 database* as well as associated pre-trained variational models. Together with `<strong>orthos</strong>` it was developed to provide a better understanding of the effects of experimental treatments on gene expression and to help map treatments to mechanisms of action.
description: *Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Wang L, Silverstein MC, Ma'ayan A. Massive mining of publicly available RNA-seq data from human and mouse. Nature Communications 9. Article number: 1366 (2018), doi:10.1038/s41467-018-03751-6
DOI: 10.5281/zenodo.7908269
title: orthosData

description: `<strong>orthosData</strong>` is the companion database to the `<strong>orthos</strong>` software for mechanistic studies using differential gene expression experiments. It currently encompasses data for over 100,000 differential gene expression mouse and human experiments distilled and compiled from the ARCHS4 database* as well as associated pre-trained variational models. Together with `<strong>orthos</strong>` it was developed to provide a better understanding of the effects of experimental treatments on gene expression and to help map treatments to mechanisms of action.
description: *Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Wang L, Silverstein MC, Ma'ayan A. Massive mining of publicly available RNA-seq data from human and mouse. Nature Communications 9. Article number: 1366 (2018), doi:10.1038/s41467-018-03751-6
DOI: 10.6084/m9.figshare.22785432
title: A proposed new frame score system for Nellore cattle

description: Abstract A new frame score system was developed for Nellore cattle, based upon ideal slaughter weights to achieve desired degrees of carcass fat cover. Data consisting of 688 complete records including sex, age, weight, hip height, and subcutaneous fat on growing Nellore cattle (190 males and 498 females) were obtained from the National Association of Breeders and Researchers (ANCP), Ribeirão Preto – SP, Brazil. Weight data were regressed on sex, age, hip height, and fat cover as covariates. Age was then fixed at 550 days and fat cover was set to 6 mm, and new equations for frame scores (1 to 11) in Nellore cattle were developed: FrameNellore (males) = -42.43 + 0.04919 × Age + 0.3368 × Height – 0.0003369 × Age × Height and FrameNellore (females) = -41.76 + 0.04919 × Age + 0.3368 × Height – 0.0003369 × Age × Height (Age and Height in days and cm, respectively). The Nellore equations resulted in average frame of 5.3, ranging from 2.3 to 7.7. Values were similar for males (5.4) and females (5.3). By contrast, previous equations gave higher values, that were very different between males and females. The new Nellore frame scores appear reasonable, particularly regarding body composition.
DOI: 10.6084/m9.figshare.22785432.v1
title: A proposed new frame score system for Nellore cattle

description: Abstract A new frame score system was developed for Nellore cattle, based upon ideal slaughter weights to achieve desired degrees of carcass fat cover. Data consisting of 688 complete records including sex, age, weight, hip height, and subcutaneous fat on growing Nellore cattle (190 males and 498 females) were obtained from the National Association of Breeders and Researchers (ANCP), Ribeirão Preto – SP, Brazil. Weight data were regressed on sex, age, hip height, and fat cover as covariates. Age was then fixed at 550 days and fat cover was set to 6 mm, and new equations for frame scores (1 to 11) in Nellore cattle were developed: FrameNellore (males) = -42.43 + 0.04919 × Age + 0.3368 × Height – 0.0003369 × Age × Height and FrameNellore (females) = -41.76 + 0.04919 × Age + 0.3368 × Height – 0.0003369 × Age × Height (Age and Height in days and cm, respectively). The Nellore equations resulted in average frame of 5.3, ranging from 2.3 to 7.7. Values were similar for males (5.4) and females (5.3). By contrast, previous equations gave higher values, that were very different between males and females. The new Nellore frame scores appear reasonable, particularly regarding body composition.
DOI: 10.6084/m9.figshare.22785435
title: Administrative law of innovation and experimentalism: the bold move between risks, controls, and collaboration

description: Abstract: Innovation refers to the phenomenon of creation, introduction of novelties, and recombinations. It is linked to radical changes or incremental reformulations of something already existing. The term has gained significant space in economics studies, but as time has progressed it has inevitably reached the field of law. In this context, this research focuses on delineating an adequate notion of innovation for the Brazilian Public Administration, elaborating its own experimental flow and addressing the perspectives of innovation for public management. It seeks, primarily, to present innovation, experimentalism and its challenges for an innovative management model. Methodologically, the research has a deductive approach, based on bibliographic and documental research techniques. The conclusion is that innovation, for the Public Administration, means creating or recombining services and goods with the aim of conforming to the public interest, observing an adequate experimental flow. The consolidation of an innovative administration also depends on the change of culture in the management and in the control bodies. Finally, there must be investment in research, science and technology, and digital literacy for the collaborative model of management that is demanded by innovation.
DOI: 10.6084/m9.figshare.22785435.v1
title: Administrative law of innovation and experimentalism: the bold move between risks, controls, and collaboration

description: Abstract: Innovation refers to the phenomenon of creation, introduction of novelties, and recombinations. It is linked to radical changes or incremental reformulations of something already existing. The term has gained significant space in economics studies, but as time has progressed it has inevitably reached the field of law. In this context, this research focuses on delineating an adequate notion of innovation for the Brazilian Public Administration, elaborating its own experimental flow and addressing the perspectives of innovation for public management. It seeks, primarily, to present innovation, experimentalism and its challenges for an innovative management model. Methodologically, the research has a deductive approach, based on bibliographic and documental research techniques. The conclusion is that innovation, for the Public Administration, means creating or recombining services and goods with the aim of conforming to the public interest, observing an adequate experimental flow. The consolidation of an innovative administration also depends on the change of culture in the management and in the control bodies. Finally, there must be investment in research, science and technology, and digital literacy for the collaborative model of management that is demanded by innovation.