cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24145290.v1
title: Supplementary Material for: Disease burden and epidemiological trends of chronic kidney disease at the global, regional, national levels from 1990 to 2019

description: Background: Chronic kidney disease (CKD) is a serious public health issue worldwide, but the disease burden of CKD caused by different etiologies and changing trends have not been fully examined. Methods: We collected data from Global Burden of Disease Study 2019 (GBD 2019), including incident cases, age-standardized incidence rate (ASIR), disability-adjusted life years (DALYs), and age-standardized DALY rate between 1990 and 2019 by region, etiology, age, and sex, and calculated the estimated annual percentage change (EAPC) of the rate to evaluate the epidemiological trends. Results: Globally, incident cases of CKD increased from 7.80 million in 1990 to 18.99 million in 2019, and DALYs increased from 21.50 million to 41.54 million. ASIR increased with an EAPC of 0.69 (95% UI 0.49-0.89) and reached 233.65 per 100,000 in 2019, while the age-standardized DALY rate increased with an EAPC of 0.30 (95% UI 0.17-0.43) and reached 514.86 per 100,000. North Africa and Middle East, central Latin America and North America had the highest ASIR in 2019. Central Latin America had the highest age-standardized DALY rate meanwhile. Almost all countries experienced an increase in ASIR, and over 50% of countries had an increasing trend in age-standardized DALY rate from 1990 to 2019. CKD due to diabetes mellitus type 2 and hypertension accounted for the largest disease burden with 85% incident cases and 66% DALYs in 2019 of known causes, with the highest growth in age-standardized DALY rate and a similar geographic pattern to that of total CKD. Besides, the highest incidence rate of total and four specific CKDs were identified in people aged 70-plus years, who also had the highest DALY rate with a stable trend after 2010. Females had a higher ASIR, while males had a higher age-standardized DALY rate, the gap of which was most distinctive in CKD due to hypertension. Conclusion: The disease burden of CKD remains substantial and continues to grow globally. From 1990 to 2019, global incident cases of CKD have more than doubled and DALYs have almost doubled and surpassed 40 million years. CKD due to diabetes mellitus type 2 and hypertension contribute nearly 2/3 DALYs in 2019 of known causes, and had witnessed the highest growth in age-standardized DALY rate. Etiology-specific prevention strategies should be placed a high priority on the goal of precise control of CKD.
DOI: 10.5281/zenodo.8347427
title: Put Your Money Where Your Mouth Is: Analysis and Characterization of Real World Habit Building Attempts

description: Data and code for double blind review of submission titled "Put Your Money Where Your Mouth Is: Analysis and Characterization of Real World Habit Building Attempts"
DOI: 10.5281/zenodo.8347426
title: Put Your Money Where Your Mouth Is: Analysis and Characterization of Real World Habit Building Attempts

description: Data and code for double blind review of submission titled "Put Your Money Where Your Mouth Is: Analysis and Characterization of Real World Habit Building Attempts"
DOI: 10.6084/m9.figshare.24145128.v1
title: Example data used for SACNet.

description: This is the example data used for SACNet at https://github.com/RicardoZiTseng/SACNet/tree/main.
DOI: 10.6084/m9.figshare.24145128
title: Example data used for SACNet.

description: This is the example data used for SACNet at https://github.com/RicardoZiTseng/SACNet/tree/main.
DOI: 10.57967/hf/1115
title: crawl-theedgemalaysia
DOI: 10.5281/zenodo.8347663
title: Radiocarbon dates from Houses of Fosie Type

description: Radiocarbon dates from Houses of Fosie Type
DOI: 10.5281/zenodo.8347662
title: Radiocarbon dates from Houses of Fosie Type

description: Radiocarbon dates from Houses of Fosie Type
DOI: 10.6084/m9.figshare.24145383
title: Supplementary Material for: Impact of 14 days of bed rest in older adults and an exercise countermeasure on body composition, muscle strength and cardiovascular function: Canadian Space Agency standard measures

description: Introduction: Head-down bed rest (HDBR) has long been used as an analog to microgravity and it also enables studying the changes occurring with aging. Exercise is the most effective countermeasure for the deleterious effects of inactivity. The aim of this study was to investigate the efficacy of an exercise countermeasure in healthy older participants on attenuating musculoskeletal deconditioning, cardiovascular fitness level and muscle strength during l4 days of HDBR as part of the standard measures of the Canadian Space Agency. Methods: Twenty-three participants (12 males and 11 females), aged 55-65 years, were admitted for a 26-day inpatient stay at the McGill University Health Centre. After 5 days of baseline assessment tests, they underwent 14 days of continuous HDBR followed by 7 days of recovery with repeated tests. Participants were randomized to passive physiotherapy or an exercise countermeasure during the HDBR period consisting in 3 sessions per day of either high-intensity interval training (HIIT) or low-intensity cycling or strength exercises for the lower and upper body. Peak aerobic power (V̇O2peak) was determined using indirect calorimetry. Body composition was assessed by dual-energy X-ray absorptiometry (DXA) and several muscle group strengths were evaluated using an adjustable chair dynamometer. A vertical jump was used to assess whole-body power output and a tilt test to measure cardiovascular and orthostatic challenge. Additionally, changes in various blood parameters were measured as well as the effects of exercise countermeasure on these measurements. Results: There were no differences at baseline in main characteristics between the control and exercise groups. The exercise group maintained V̇O2peak levels similar to baseline whereas it decreased in the control group following 14 days of HDBR. Body weight significantly decreased in both groups. Total and leg lean masses decreased in both groups. However, total body fat mass decreased only in the exercise group. Isometric and isokinetic knee extension muscle strength was significantly reduced in both groups. Peak velocity, flight height and flight time were significantly reduced in both groups with HDBR. Conclusion: In this first Canadian HDBR study in older adults, an exercise countermeasure helped maintain aerobic fitness and lean body mass without affecting the reduction of knee extension strength. However, it was ineffective in protecting against orthostatic intolerance. These results support HIIT as a promising approach to preserve astronaut health and functioning during space missions, and to prevent deconditioning as a result of hospitalization in older adults.
DOI: 10.5281/zenodo.8347377
title: Overtrust 3D dataset - Part II

description: Overtrust 3D dataset - Part II
DOI: 10.5281/zenodo.8347376
title: Overtrust 3D dataset - Part II

description: Overtrust 3D dataset - Part II
DOI: 10.5281/zenodo.8347487
title: Data to reproduce analysis in Convergent evolution of extrachromosomal DNA in mCRPC paper

description: Targeted cancer therapies can prolong the lives of men with metastatic castration resistant prostate cancer (mCRPC). However, these treatments also selectively favor the growth of tumor cells that harbor therapy resistance, and mCRPC is currently lethal. It has been challenging to study factors influencing how therapy resistance develops in this setting because few autopsy studies of have been performed in the settings of DNA-repair deficient mCRPC. Here, we assessed how resistance to targeted cancer therapies evolved in an autopsy cohort of 53 mCRPC tumors from six such men using deep whole genome and transcriptome analysis, validating our observations in an independent cohort of 135 mCRPC tumors. We identified intra-patient heterogeneity in clinically actionable DNA repair deficiencies and transcriptionally-defined tumor subtypes. Identical polygenic DNA repair resistance mutations were present in physically distinct tumors within the same individual, suggesting that these mutations pre-exist selection by later targeted therapy. Extra-chromosomal DNA (ecDNA) was present in more than half of mCRPC biopsies and frequently amplified the androgen receptor (<em>AR</em>) and enhancers of <em>AR</em> and <em>MYC</em>. Individual ecDNA amplicons included multiple driver genes on different chromosomes, and arose multiple times within distinct tumors in a single patient. The presence of ecDNA was significantly associated with whole genome doubling, chromothripsis, and with inactivating <em>TP53</em> alterations. We conclude that ecDNA amplification is a major contributor to therapy resistance in mCRPC and that late-stage mCRPC develops intra-patient heterogeneity in response to targeted therapy.
DOI: 10.5281/zenodo.8347486
title: Data to reproduce analysis in Convergent evolution of extrachromosomal DNA in mCRPC paper

description: Targeted cancer therapies can prolong the lives of men with metastatic castration resistant prostate cancer (mCRPC). However, these treatments also selectively favor the growth of tumor cells that harbor therapy resistance, and mCRPC is currently lethal. It has been challenging to study factors influencing how therapy resistance develops in this setting because few autopsy studies of have been performed in the settings of DNA-repair deficient mCRPC. Here, we assessed how resistance to targeted cancer therapies evolved in an autopsy cohort of 53 mCRPC tumors from six such men using deep whole genome and transcriptome analysis, validating our observations in an independent cohort of 135 mCRPC tumors. We identified intra-patient heterogeneity in clinically actionable DNA repair deficiencies and transcriptionally-defined tumor subtypes. Identical polygenic DNA repair resistance mutations were present in physically distinct tumors within the same individual, suggesting that these mutations pre-exist selection by later targeted therapy. Extra-chromosomal DNA (ecDNA) was present in more than half of mCRPC biopsies and frequently amplified the androgen receptor (<em>AR</em>) and enhancers of <em>AR</em> and <em>MYC</em>. Individual ecDNA amplicons included multiple driver genes on different chromosomes, and arose multiple times within distinct tumors in a single patient. The presence of ecDNA was significantly associated with whole genome doubling, chromothripsis, and with inactivating <em>TP53</em> alterations. We conclude that ecDNA amplification is a major contributor to therapy resistance in mCRPC and that late-stage mCRPC develops intra-patient heterogeneity in response to targeted therapy.
DOI: 10.6084/m9.figshare.24145392
title: ELIFE pan-cancer data

description: Metadata of dataset for ELIFE paper about pan-cancer early detection using SPOT-MAS testProcessed data of 8630 features used in this paper
DOI: 10.25345/c5pk07c2c
title: MassIVE MSV000092865 - The Dataset of sesquiterpenes from the daphne genus -TEST-230915
title: The dataset of the sesquiterpenes isolated from the plants of dapnhe genus is built for the further researches about the phytochemical studies on the genus.
DOI: 10.6084/m9.figshare.24145416
title: Data Heinze et al. Stress Biology.xlsx

description: Data associated with Heinze et al. 2023 Stress Biology
DOI: 10.6084/m9.figshare.24145416.v1
title: Data Heinze et al. Stress Biology.xlsx

description: Data associated with Heinze et al. 2023 Stress Biology
DOI: 10.25345/c5js9hj82
title: MassIVE MSV000092866 - GNPS_dataset_WangYuLe-NEG-20230915-Sample1
title: Traditional Chinese medicine, with a history spanning over thousands of years, is based on the principles of holistic healthcare and natural healing.
DOI: 10.5519/qd.0otxwcyc
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (1 records)
DOI: 10.5281/zenodo.8336016
title: ERK activity in migrating MDA-MB-231 cells (clover-ERK-KTR + sir-DNA)

description: MDA-MB-231 or U2OS cells stably expressing clover-ERK-KTR were seeded on fibronectin-coated (1 µg /ml) Ibidi 8-well slides (Ibidi) 1 day before imaging. Four hours before imaging, the medium was supplemented with 250 nM sir-DNA (Cytoskeleton) and 25 mM HEPES (Sigma). Cells were then imaged live (37 °C, 5% CO<sub>2</sub>) using a Nikon Eclipse Ti2-E microscope (Nikon) equipped with an sCMOS Orca Flash4.0 camera (Hamamatsu) and controlled by the NIS-Elements software (Nikon, v 5.11.01). MDA-MB-231 cells were imaged using a 20× Nikon CFI Plan Apo Lambda objective (NA 0.75), either 1 frame per minute for 2 hours or 1 frame every 5 minutes for 17 hours. In these experiments, a camera binning of 2 × 2 was used. This dataset consists of 20 videos.
DOI: 10.5281/zenodo.8336015
title: ERK activity in migrating MDA-MB-231 cells (clover-ERK-KTR + sir-DNA)

description: MDA-MB-231 or U2OS cells stably expressing clover-ERK-KTR were seeded on fibronectin-coated (1 µg /ml) Ibidi 8-well slides (Ibidi) 1 day before imaging. Four hours before imaging, the medium was supplemented with 250 nM sir-DNA (Cytoskeleton) and 25 mM HEPES (Sigma). Cells were then imaged live (37 °C, 5% CO<sub>2</sub>) using a Nikon Eclipse Ti2-E microscope (Nikon) equipped with an sCMOS Orca Flash4.0 camera (Hamamatsu) and controlled by the NIS-Elements software (Nikon, v 5.11.01). MDA-MB-231 cells were imaged using a 20× Nikon CFI Plan Apo Lambda objective (NA 0.75), either 1 frame per minute for 2 hours or 1 frame every 5 minutes for 17 hours. In these experiments, a camera binning of 2 × 2 was used. This dataset consists of 20 videos.
DOI: 10.5281/zenodo.8347775
title: ERK activity in migrating MDA-MB-231 cells (clover-ERK-KTR + sir-DNA)

description: MDA-MB-231 or U2OS cells stably expressing clover-ERK-KTR were seeded on fibronectin-coated (1 µg /ml) Ibidi 8-well slides (Ibidi) 1 day before imaging. Four hours before imaging, the medium was supplemented with 250 nM sir-DNA (Cytoskeleton) and 25 mM HEPES (Sigma). Cells were then imaged live (37 °C, 5% CO<sub>2</sub>) using a Nikon Eclipse Ti2-E microscope (Nikon) equipped with an sCMOS Orca Flash4.0 camera (Hamamatsu) and controlled by the NIS-Elements software (Nikon, v 5.11.01). MDA-MB-231 cells were imaged using a 20× Nikon CFI Plan Apo Lambda objective (NA 0.75), either 1 frame per minute for 2 hours or 1 frame every 5 minutes for 17 hours. In these experiments, a camera binning of 2 × 2 was used. This dataset consists of 20 videos.
DOI: 10.34740/kaggle/dsv/6476611
title: WB_WoB-ReID dataset for person reidentification
DOI: 10.14457/rmutk.the.2023.2
title: ปัจจัยที่มีอิทธิพลต่อการตัดสินใจยอมรับการใช้สกุลเงินดิจิทัล

description: งานวิจัยครั้งนี้มีวัตถุประสงค์ 1) เพื่อศึกษาระดับความคิดเห็นของปัจจัยด้านความไว้วางใจด้านอิทธิพลทางสังคม ด้านความคาดหวังในประสิทธิภาพ ด้านความคาดหวังในความพยายามด้านสภาพสิ่งอำนวยความสะดวก ด้านมูลค่าตามราคา และการตัดสินใจยอมรับการใช้สกุลเงินดิจิทัล 2) เพื่อวิเคราะห์อิทธิพลของปัจจัยที่มีต่อการตัดสินใจยอมรับการใช้สกุลเงินดิจิทัล เก็บรวบรวมข้อมูล ด้วยแบบสอบถามออนไลน์ผ่าน Google From กลุ่มตัวอย่างคือผู้ที่มีประสบการณ์ สนใจการใช้ สกุลเงินดิจิทัล จากกลุ่มผู้ใช้งานออนไลน์ จำนวน 400 ตัวอย่าง ด้วยการสุ่มตัวอย่างแบบชั้นภูมิ จาก กลุ่มที่สนใจสกุลเงินดิจิทัล วิเคราะห์ข้อมูลด้วยค่าร้อยละ ค่าเฉลี่ย ค่าเบี่ยงเบนมาตรฐาน และ การวิเคราะห์ถดถอยเชิงเส้นพหุ ผลการวิจัยพบว่า (1) ระดับความคิดเห็นของปัจจัยด้านความไว้วางใจ ปัจจัยด้านอิทธิพลทางสังคม ปัจจัยด้านความคาดหวังในประสิทธิภาพ ปัจจัยด้านความคาดหวังในความพยายาม ปัจจัยด้านสภาพสิ่งอำนวยความสะดวก ปัจจัยด้านมูลค่าตามราคา และการตัดสินใจยอมรับการใช้สกุลเงินดิจิทัลมีระดับเห็นด้วยมาก (Z = 3.72 - 4.05) (2) ปัจจัยด้านความไว้วางใจ ปัจจัยด้านอิทธิพลทางสังคม ปัจจัยด้านความคาดหวังในประสิทธิภาพ ปัจจัยด้านความคาดหวังในความพยายาม ปัจจัยด้านสภาพ สิ่งอำนวยความสะดวก และปัจจัยด้านมูลค่าตามราคา ส่งผลต่อการตัดสินใจยอมรับการใช้สกุลเงินดิจิทัล อย่างมีนัยสำคัญทางสถิติ มีค่าสัมประสิทธิ์สหสัมพันธ์พหุคูณ อยู่ในระดับมากที่สุด (R = 0.953) มีอำนาจในการพยากรณ์ร้อยละ 90.8 และมีความคลาดเคลื่อนมาตรฐานของการพยากรณ์เท่ากับ0.30755 (SEE 0.30755) ปัจจัยที่มีอิทธิพลต่อการตัดสินใจยอมรับการใช้สกุลเงินดิจิทัลมากที่สุดคือ ปัจจัยด้านสภาพสิ่งอำนวยความสะดวก ปัจจัยด้านความคาดหวังในประสิทธิภาพ ปัจจัยด้านความคาดหวังในความพยายาม ปัจจัยด้านความไว้วางใจ ปัจจัยด้านมูลค่าตามราคา และปัจจัยด้านอิทธิพลทางสังคม มีค่าสัมประสิทธิ์การถดถอยเท่ากับ 0.329 0.158 0.156 0.123 0.119 และ 0.114
DOI: 10.48512/xcv8488767
title: Dataset for: Title: Visible Wealth in Past Societies: A Case Study of Domestic Architecture from the Hawaiian Islands

description: Dataset for: Title: Visible Wealth in Past Societies: A Case Study of Domestic Architecture from the Hawaiian Islands Authors: Mark D. McCoy, Joseph L. Panuska
DOI: 10.6084/m9.figshare.24145485
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24145491
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.
DOI: 10.6084/m9.figshare.24145491.v1
title: Supplementary Material for: Two distinct characteristics of immune microenvironment in human hepatocellular carcinoma with Wnt/β-catenin mutations

description: Introduction Immunotherapy is becoming a promising approach for unresectable-hepatocellular carcinoma (HCC); the anti-tumor response is affected by the tumor microenvironment (TME). Although Wnt/β-catenin mutations are reported to cause non-inflamed phenotype, their role on TME remains controversial. We aimed to clarify the heterogeneity of immunophenotype in HCC with Wnt/β-catenin mutations. Methods This study includes 152 resected HCCs; mutations in the catenin beta-1, adenomatous polyposis coli, or AXIN1, or AXIN2 genes were defined as Wnt/β-catenin mutations. With hierarchical cluster analyses, TME were classified into inflamed or non-inflamed classes based on the gene expressions associated with T-cell activation. Expression profiles of molecules related to cell differentiation and biliary-stem cell markers were compared between the TME classes to investigate whether differences in tumor traits were associated with TME. Results Forty of 152 (26.3%) HCCs carried the Wnt/β-catenin mutations. Of these, 33 were classified as non-inflamed (33/40, 82.5%) and 7 as inflamed (7/40, 17.5%). Non-inflamed class was characterized by low number of CD3+, CD4+, and CD8+ cells on immunostaining, and high mRNA expressions of AXIN2 and GLUL, which are involved in the canonical Wnt/β-catenin signaling and hepatocyte differentiation, respectively. Non-inflamed tumors showed higher enhancement on the hepatobiliary-phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) compared to inflamed tumors. HCCs classified as inflamed class are revealed to have high numbers of CD3+, CD4+, and CD8+ tumor infiltrating lymphocytes on immunostaining. This class is associated with increased expression of anti-epithelial cell adhesion molecule (EpCAM) and FOXM1 accompanied by upregulation of genes related to interferon-gamma signaling, dendritic cell migration, regulatory T cells and MDSC activation and recognized as low enhancement nodule on Gd-EOB-DTPA-enhanced MRI. Conclusion Heterogeneity of tumor traits and TME was observed in HCC with Wnt/β-catenin mutation. The potential was indicated that tumor traits and TME are determined not only by the activation of the HNF4A but also by FOXM1, both of which are downstream transcription factor of the Wnt/β-catenin signaling pathway.