cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.9927872.v1
title: LIPIDS AS COMPETITIVE INHIBITORS OF SUBTILISIN CARLSBERG IN THE ENZYMATIC HYDROLYSIS OF PROTEINS IN RED TILAPIA (Oreochromis sp.) VISCERA: INSIGHTS FROM KINETIC MODELS AND A MOLECULAR DOCKING STUDY

description: Abstract Protein hydrolysis can improve food’s nutritional, techno-functional and biological properties, which can increase the possibilities of application in industry. The objective of this research article was to study the effect of lipids on the enzymatic kinetics of red tilapia viscera (RTV) hydrolysis with subtilisin Carlsberg. The RTV were hydrolyzed in an enzyme/substrate ratio of 0.153 (U/g), at 53° C, at a pH of 9.5, initial concentrations of lipids of 1, 19 and 50 g/L, and different initial substrate concentrations for each initial lipid concentration. To explain the lipid action mechanism, we evaluated a Michaelis-Menten model and another semi-physical model based on kinetic expressions and mass balances. Additionally, a molecular docking analysis was performed between subtilisin Carlsberg and the main fatty acid in RTV (palmitic acid). For both models, the results suggest a strong competitive inhibition by lipids, with an inhibition constant of 2.36 and 3.01 g/L for the first and second models, respectively. On the other hand, docking suggested that palmitic acid could form van der Waals interactions and hydrogen bonds with the residues of the active site of subtilisin Carlsberg and occupy part of the substrate binding site, thus acting as an effective competitive inhibitor.
DOI: 10.6084/m9.figshare.9927875.v1
title: SYNTHESIS AND CHARACTERIZATION OF FRUCTOSYLTRANSFERASE FROM Aspergillus oryzae IPT-301 FOR HIGH FRUCTOOLIGOSACCHARIDES PRODUCTION

description: Abstract Fructooligosaccharides (FOS) are mainly produced by microbial fructosyltransferases (FTase, E.C.2.4.1.9), and Aspergillus oryzae IPT-301 has shown high fructosyl transferring and low hydrolytic activities, which leads to high FOS production yields, but the main operating parameters for its best performance have been scarcely studied. Thus, this work aimed to evaluate the cellular growth, production and characterization of mycelial and extracellular FTases by Aspergillus oryzae IPT-301. Experimental design showed that the extracellular FTase performance was optimized (high transfructosylation activity and low hydrolytic activity) for reaction pH 5.5 - 6.75 and temperature of 45-50 °C and was fitted by the Michaelis-Menten model, while the mycelial FTase showed better performance at pH below 6.5 and temperature above 46 °C and was better fitted by the Hill model. The results obtained showed that the fungus represents a promising source for FOS production on a laboratorial scale.
DOI: 10.6084/m9.figshare.9927866
title: Progesterone’s Serum Level and a New Ultrasonographic Parameter in the First Trimester Pregnancy - Prognostic Factors for Embryonic Demise

description: Abstract Objective The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (40%). The purpose of the present study is to evaluate the correlation between a serum biomarker, progesterone, and an ultrasonographic parameter, the distance between yolk sac and embryo (DYSE) in assessing the prognosis of pregnancy outcome in the 1st trimester. Methods The present study is a prospective case-control analysis that includes 2 groups of patients: 81 patients with first-trimester normal evolutive pregnancy and 89 patients with embryonic demise, all of the patients having between 6 and 11 weeks of amenorrhea. Endovaginal ultrasonographic exploration was performed to evaluate the distance between the lower pole of the embryo and the yolk sac. From each subject enrolled in the study, 20ml of blood was collected for progesterone serum level measurement. Results Regarding the DYSE in the case group, lower values were observed compared with the control group, the difference being statistically significant. In the statistical analysis of serum progesterone values, statistically significant differences were observed between the 2 groups (p&lt;0.05). Conclusion The DYSE has a high positive predictive value in identifying pregnancies with potentially reserved outcome, with the present study demonstrating that a DYSE&lt;3mm causes an unfavorable evolution of the pregnancy. Low serum levels of progesterone are associated with an increased rate of nonviable embryos. The correlation between these two parameters increases the effectiveness of screening methods in prenatal monitoring and improves the diagnostic methods for the firsttrimester pregnancies whose outcome potential can be reserved.
DOI: 10.6084/m9.figshare.9927869
title: Oral health care for people with visual impairment

description: Abstract Background approximately 285 million people are visually impaired, oral health care to people with visual impairment differs due to the conditions’ limitations, which may affect the individuals’ dental care. Objective to evaluate the access and satisfaction of people with visual impairment to oral health services and their relationship with the economic condition. Method this is a cross-sectional quantitative study involving people with visual impairment of an Institute for the Blind. A semi-structured questionnaire was used to obtain data, where variables were: access to oral health services, satisfaction and socioeconomic status. After the data collection, the data were tabulated by Epi Info 7.2. Results of the total number of respondents (n = 72), 65.28% were males, with a mean age of 34.6 years. Regarding access to oral health services, 56.9% of the interviewees reported that the last visit to the dentist was less than one year, and the majority (84.3%) classified the treatment of the last consultation with good or very good. Access to oral health services occurred in both the public and private systems, regardless of the economic class of the respondent (p = 0.174). Conclusion in spite of the positive results, access and dental care for people with visual impairment requires the creation and expansion of inclusion and accessibility policies.
DOI: 10.6084/m9.figshare.9927860
title: Association between the habit of reading food labels and health-related factors in elderly individuals of the community

description: ABSTRACT Objective To investigate the association between the habit of reading food labels and health related factors in elderly individuals who are members of social groups in the city of Governador Valadares, in the state of Minas Gerais, Brazil. Methods This cross-sectional study interviewed 141 individuals, members of elderly social groups. The socioeconomic and health profile was defined based on sex, age, marital status, educational level, disease occurrence, use of medication, physical exercise and self-perception of health. The habit of reading the food labels was assessed through the question: “Do you read the food label before purchasing or consuming the product?”. In case of an affirmative answer, researchers asked which items from the labels were observed by the individual. Weekly food intake was assessed through a food frequency questionnaire and classified in scores. The anthropometric evaluation was based on the calculation and classification of the Body Mass Index. A multinomial logistic regression was used to determine factors associated with the habit of reading the labels, and it was considered significant when p&lt;0.025. Results The habit of reading labels was reported by 72.3% of the participants, whom predominantly verified the product’s expiration date (90.2%), followed by the amount of fat (18.4%) and sodium (16.7%) in it. This behavior was independently associated with a lower mean consumption of medicines, a lower per capita household consumption of sugar and a higher weekly frequency of per capita whole grain consumption. Conclusion The habit of reading the food labels is associated with a better health condition and with a healthier eating behavior among elderly individuals and it should be considered as an important nutritional strategy in this age group.
DOI: 10.6084/m9.figshare.9927857
title: Prevalence of Sexual Dysfunctions and their Associated Factors in Pregnant Women in an Outpatient Prenatal Care Clinic

description: Abstract Objective To determine the prevalence of sexual dysfunction and its associated factors in pregnant women. Methods A descriptive, cross-sectional study including 262 pregnant women aged 18 years or older with gestational age between 10 and 35 weeks. Women with urinary tract infections and conditions of gestational risk were excluded. The Pregnancy Sexual Response Inventory (PSRI) questionnaire was used. We performed a univariate descriptive analysis, and comparisons between the mean values of the sexual function domains were made using the Student t-test. The chi-squared test was used to determine the association between the independent and dependent variables. The prevalence ratios, with their respective 95% confidence intervals, were also estimated, and a multivariate analysis was performed. Results A total of 64.9% of women reported a decrease in the frequency of sexual activity during pregnancy. Slightly more than half of the women (50.8%) were satisfied, and arousal was reported as excellent/good by 30.5% of them. The frequency of sexual difficulties/dysfunctions increased with pregnancy, rising from 5.7% to 58.8%, and pain during sexual intercourse was reported by 45.8% of them. Having higher education degree decreased the chance of being sexually dissatisfied by 50%. The total PSRI score showed a significant decrease from the prepregnancy period (mean score = 89.8, “excellent”) to the pregnancy period (mean score = 59.2, “good”). Conclusion The mean sexual function score during pregnancy was classified as good, although most pregnant women reported at least one type of alteration in the sexual function domains, and the report of dissatisfaction was more frequent in women with lower schooling.
DOI: 10.6084/m9.figshare.9927863
title: The prescription of psychotropic medication and the knowledge of brazilian regulatory legislation by dental surgeons

description: Abstract Background The use of psychotropics by dental surgeons is permitted by law in Brazil for specific clinical cases. There are few studies on its use in dentistry. Objective This study investigated the prescription of psychotropics drugs by dentists enrolled in the Regional Council of Minas Gerais and their knowledge about regulatory ordinance 344/1998. Method An electronic questionnaire with 13 questions addressing the prescription of psychotropic drugs was sent to 15250 dental surgeons and 969 questionnaires were answered. It was considered the time of graduation, type of undergraduate institution, type of postgraduate course, more frequent prescribed medication, knowledge about ordinance 344/1998 and more frequent public that receives the prescription. Results Two hundred and fifty-seven professionals prescribe psychotropic drugs and 223 know the law, and a worrying percentage of professionals who prescribe these drugs does not know the content of the Ordinance 344/1998. Opioid analgesics are the most prescribed psychotropic medications. Specialists are the ones who prescribe psychotropic drugs (p=0.015) and those professionals who prescribe anxiolytics know the legislation more frequently (p=0.003). The maxillofacial surgeons (p=0.02) and experts in disorders of the temporomandibular jaw joint (0.03) are the ones who know the law and prescribe psychotropic medication. Strong pain and fear are the two main reasons for prescribing psychotropic drugs. Conclusion Being a specialist and knowing the ordinance 344/1998 are factors associated with the prescription of psychotropic medications among dentists.
DOI: 10.6084/m9.figshare.9927866.v1
title: Progesterone’s Serum Level and a New Ultrasonographic Parameter in the First Trimester Pregnancy - Prognostic Factors for Embryonic Demise

description: Abstract Objective The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (40%). The purpose of the present study is to evaluate the correlation between a serum biomarker, progesterone, and an ultrasonographic parameter, the distance between yolk sac and embryo (DYSE) in assessing the prognosis of pregnancy outcome in the 1st trimester. Methods The present study is a prospective case-control analysis that includes 2 groups of patients: 81 patients with first-trimester normal evolutive pregnancy and 89 patients with embryonic demise, all of the patients having between 6 and 11 weeks of amenorrhea. Endovaginal ultrasonographic exploration was performed to evaluate the distance between the lower pole of the embryo and the yolk sac. From each subject enrolled in the study, 20ml of blood was collected for progesterone serum level measurement. Results Regarding the DYSE in the case group, lower values were observed compared with the control group, the difference being statistically significant. In the statistical analysis of serum progesterone values, statistically significant differences were observed between the 2 groups (p&lt;0.05). Conclusion The DYSE has a high positive predictive value in identifying pregnancies with potentially reserved outcome, with the present study demonstrating that a DYSE&lt;3mm causes an unfavorable evolution of the pregnancy. Low serum levels of progesterone are associated with an increased rate of nonviable embryos. The correlation between these two parameters increases the effectiveness of screening methods in prenatal monitoring and improves the diagnostic methods for the firsttrimester pregnancies whose outcome potential can be reserved.
DOI: 10.6084/m9.figshare.9927869.v1
title: Oral health care for people with visual impairment

description: Abstract Background approximately 285 million people are visually impaired, oral health care to people with visual impairment differs due to the conditions’ limitations, which may affect the individuals’ dental care. Objective to evaluate the access and satisfaction of people with visual impairment to oral health services and their relationship with the economic condition. Method this is a cross-sectional quantitative study involving people with visual impairment of an Institute for the Blind. A semi-structured questionnaire was used to obtain data, where variables were: access to oral health services, satisfaction and socioeconomic status. After the data collection, the data were tabulated by Epi Info 7.2. Results of the total number of respondents (n = 72), 65.28% were males, with a mean age of 34.6 years. Regarding access to oral health services, 56.9% of the interviewees reported that the last visit to the dentist was less than one year, and the majority (84.3%) classified the treatment of the last consultation with good or very good. Access to oral health services occurred in both the public and private systems, regardless of the economic class of the respondent (p = 0.174). Conclusion in spite of the positive results, access and dental care for people with visual impairment requires the creation and expansion of inclusion and accessibility policies.
DOI: 10.6084/m9.figshare.9927854
title: Prevalence of disabilities and associated aspects in women with cervical cancer, Rio de Janeiro, Brazil

description: Abstract Background Cervical cancer is the third most common cancer among women worldwide. Its incidence is considerably higher in low and middle-income countries. Objective To verify the prevalence of disability in women with cervical cancer (CC) using the International Classification of Functioning, Disability, and Health (ICF) as a reference. Method This is a cross-sectional observational study conducted with women with CC under treatment at a referral hospital in Rio de Janeiro. The ICF Checklist and a specific Quality of Life Assessment Tool (FACT - Cx, Cervix Cancer) were applied. Results A total of 116 women were included in the study. Most of them were diagnosed at stage IB, and more than half of them received chemotherapy combined with radiotherapy. The highest prevalence of disability was found for deficiency of reproductive system structures (96.6%), followed by problems with energy and impulse functions (70.3%), emotional functions (70.7%) and limitation for load and transport objects (67.2%). The domain of emotional well-being was the most compromised in the analysis by FACT-Cx. Conclusion The prevalence of disability in women with CC was high for all ICF components, reflecting the impact of both the disease and its treatment on functionality. The biopsychosocial approach should be incorporated into cancer care planning routines for women with cervical cancer.
DOI: 10.6084/m9.figshare.9927860.v1
title: Association between the habit of reading food labels and health-related factors in elderly individuals of the community

description: ABSTRACT Objective To investigate the association between the habit of reading food labels and health related factors in elderly individuals who are members of social groups in the city of Governador Valadares, in the state of Minas Gerais, Brazil. Methods This cross-sectional study interviewed 141 individuals, members of elderly social groups. The socioeconomic and health profile was defined based on sex, age, marital status, educational level, disease occurrence, use of medication, physical exercise and self-perception of health. The habit of reading the food labels was assessed through the question: “Do you read the food label before purchasing or consuming the product?”. In case of an affirmative answer, researchers asked which items from the labels were observed by the individual. Weekly food intake was assessed through a food frequency questionnaire and classified in scores. The anthropometric evaluation was based on the calculation and classification of the Body Mass Index. A multinomial logistic regression was used to determine factors associated with the habit of reading the labels, and it was considered significant when p&lt;0.025. Results The habit of reading labels was reported by 72.3% of the participants, whom predominantly verified the product’s expiration date (90.2%), followed by the amount of fat (18.4%) and sodium (16.7%) in it. This behavior was independently associated with a lower mean consumption of medicines, a lower per capita household consumption of sugar and a higher weekly frequency of per capita whole grain consumption. Conclusion The habit of reading the food labels is associated with a better health condition and with a healthier eating behavior among elderly individuals and it should be considered as an important nutritional strategy in this age group.
DOI: 10.6084/m9.figshare.9927863.v1
title: The prescription of psychotropic medication and the knowledge of brazilian regulatory legislation by dental surgeons

description: Abstract Background The use of psychotropics by dental surgeons is permitted by law in Brazil for specific clinical cases. There are few studies on its use in dentistry. Objective This study investigated the prescription of psychotropics drugs by dentists enrolled in the Regional Council of Minas Gerais and their knowledge about regulatory ordinance 344/1998. Method An electronic questionnaire with 13 questions addressing the prescription of psychotropic drugs was sent to 15250 dental surgeons and 969 questionnaires were answered. It was considered the time of graduation, type of undergraduate institution, type of postgraduate course, more frequent prescribed medication, knowledge about ordinance 344/1998 and more frequent public that receives the prescription. Results Two hundred and fifty-seven professionals prescribe psychotropic drugs and 223 know the law, and a worrying percentage of professionals who prescribe these drugs does not know the content of the Ordinance 344/1998. Opioid analgesics are the most prescribed psychotropic medications. Specialists are the ones who prescribe psychotropic drugs (p=0.015) and those professionals who prescribe anxiolytics know the legislation more frequently (p=0.003). The maxillofacial surgeons (p=0.02) and experts in disorders of the temporomandibular jaw joint (0.03) are the ones who know the law and prescribe psychotropic medication. Strong pain and fear are the two main reasons for prescribing psychotropic drugs. Conclusion Being a specialist and knowing the ordinance 344/1998 are factors associated with the prescription of psychotropic medications among dentists.
DOI: 10.6084/m9.figshare.9927848
title: Vulnerability of ecosystems with Guadua angustifolia in Ecuador in light of climate changes1

description: ABSTRACT Guadua angustifolia bamboo is historically used by an important percentage of the rural and peri-urban population of Ecuador, especially in the construction of bridges, when events like El Niño and its consequential flooding occur. This study aimed to determine, in light of some climate change scenarios, the vulnerability rate of ecosystems where the G. angustifolia bamboo species occurs, in the coastal region of continental Ecuador. The analysis methodology, with focus on the sampled units, was based on vulnerability assessment tools for climate adaptation recommended by the Intergovernmental Panel on Climate Change.Temperature presented the highest correlation coefficient with the vulnerability rate of the ecosystems, followed by the increase in the sea level, winds and landslides. It was concluded that as the exposure and sensitivity variables increase, the adaptive capacity of ecosystems with occurence of this species decreases, and isolated plants and monoculture plantations are the most vulnerable to climate changes.
DOI: 10.6084/m9.figshare.9927854.v1
title: Prevalence of disabilities and associated aspects in women with cervical cancer, Rio de Janeiro, Brazil

description: Abstract Background Cervical cancer is the third most common cancer among women worldwide. Its incidence is considerably higher in low and middle-income countries. Objective To verify the prevalence of disability in women with cervical cancer (CC) using the International Classification of Functioning, Disability, and Health (ICF) as a reference. Method This is a cross-sectional observational study conducted with women with CC under treatment at a referral hospital in Rio de Janeiro. The ICF Checklist and a specific Quality of Life Assessment Tool (FACT - Cx, Cervix Cancer) were applied. Results A total of 116 women were included in the study. Most of them were diagnosed at stage IB, and more than half of them received chemotherapy combined with radiotherapy. The highest prevalence of disability was found for deficiency of reproductive system structures (96.6%), followed by problems with energy and impulse functions (70.3%), emotional functions (70.7%) and limitation for load and transport objects (67.2%). The domain of emotional well-being was the most compromised in the analysis by FACT-Cx. Conclusion The prevalence of disability in women with CC was high for all ICF components, reflecting the impact of both the disease and its treatment on functionality. The biopsychosocial approach should be incorporated into cancer care planning routines for women with cervical cancer.