cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.16565155.v1
title: Folic acid deficiency damages male reproduction via endoplasmic reticulum stress-associated PERK pathway induced by Caveolin-1 in mice

description: Folic acid is critical to maintaining normal male reproductive function. Endoplasmic reticulum (ER) stress plays a crucial role in folic acid deficiency. Studies have shown that Caveolin-1 (Cav-1) is involved in ER stress, but the specific mechanism in male reproduction is still unclear. This study aimed to investigate the effects of folic acid deficiency on spermatogenesis and elucidate the underlying mechanisms. C57BL/6 mice fed with folic acid deficiency induced diet(0.3 mg/kg) were used. A significant decrease in the sperm concentration in the folic acid deficiency group was observed. Meanwhile, folic acid deficiency decreased Cav-1 expression in the testis tissue and increased endoplasmic reticulum stress-related PERK, eIF2α, ATF4, CHOP gene expression. Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFα-ATF4-CHOP pathway. <b>Abbreviations</b>: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2α: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling
DOI: 10.6084/m9.figshare.19710934
title: Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury

description: Cerebral ischemia-reperfusion damages local brain tissue and impairs brain function, but its specific pathogenesis is still uncertain. Recent studies have clarified circPUM1 is aberrantly elevated in cerebral ischemia-reperfusion injury; however, circPUM1ʹs function in cerebral ischemia-reperfusion-induced neuronal injury remains ambiguous. The results illustrated circPUM1 and DEAD-box helicase 5 were decreased, but microRNA-340-5p was elevated in transient middle cerebral artery occlusion mice and oxygen glucose deprivation/reoxygenation-treated SH-SY5Y cells. Knockdown of circPUM1 aggravated the neuronal injury in transient middle cerebral artery occlusion mice and motivated glial cell activation, neuronal apoptosis and inflammation. Enhancing circPUM1 restrained oxygen glucose deprivation/reoxygenation-induced SH-SY5Y cell apoptosis, the release of lactate dehydrogenase and inflammatory factors, and activation of nuclear factor-kappaB pathway, while elevating microRNA-340-5p aggravated oxygen glucose deprivation/reoxygenation-induced cell damage. Functional rescue experiments exhibited that the impacts of knockdown or enhancement of circPUM1 were turned around by microRNA-340-5p downregulation and DEAD-box helicase 5 silencing, respectively. Moreover, it was demonstrated that circPUM1 competitively adsorbed microRNA-340-5p to mediate DEAD-box helicase 5. All in all, this study clarifies that circPUM1 mitigates cerebral ischemia-reperfusion-induced neuronal injury by targeting the microRNA-340-5p/DEAD-box helicase 5 axis.
DOI: 10.6084/m9.figshare.19710934.v1
title: Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury

description: Cerebral ischemia-reperfusion damages local brain tissue and impairs brain function, but its specific pathogenesis is still uncertain. Recent studies have clarified circPUM1 is aberrantly elevated in cerebral ischemia-reperfusion injury; however, circPUM1ʹs function in cerebral ischemia-reperfusion-induced neuronal injury remains ambiguous. The results illustrated circPUM1 and DEAD-box helicase 5 were decreased, but microRNA-340-5p was elevated in transient middle cerebral artery occlusion mice and oxygen glucose deprivation/reoxygenation-treated SH-SY5Y cells. Knockdown of circPUM1 aggravated the neuronal injury in transient middle cerebral artery occlusion mice and motivated glial cell activation, neuronal apoptosis and inflammation. Enhancing circPUM1 restrained oxygen glucose deprivation/reoxygenation-induced SH-SY5Y cell apoptosis, the release of lactate dehydrogenase and inflammatory factors, and activation of nuclear factor-kappaB pathway, while elevating microRNA-340-5p aggravated oxygen glucose deprivation/reoxygenation-induced cell damage. Functional rescue experiments exhibited that the impacts of knockdown or enhancement of circPUM1 were turned around by microRNA-340-5p downregulation and DEAD-box helicase 5 silencing, respectively. Moreover, it was demonstrated that circPUM1 competitively adsorbed microRNA-340-5p to mediate DEAD-box helicase 5. All in all, this study clarifies that circPUM1 mitigates cerebral ischemia-reperfusion-induced neuronal injury by targeting the microRNA-340-5p/DEAD-box helicase 5 axis.
DOI: 10.6084/m9.figshare.11846658
title: Additional file 10 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 10: Table S8. FPKM values of the additional 4 prochloraz-responsive unigenes in the present comparisons.
DOI: 10.6084/m9.figshare.11846658.v1
title: Additional file 10 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 10: Table S8. FPKM values of the additional 4 prochloraz-responsive unigenes in the present comparisons.
DOI: 10.6084/m9.figshare.11846673
title: Additional file 13 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 13: Table S9. Comparative analysis of prochloraz-responsive gene expression profiles between the P. italicum and P. digitatum transcriptomes.
DOI: 10.6084/m9.figshare.11846673.v1
title: Additional file 13 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 13: Table S9. Comparative analysis of prochloraz-responsive gene expression profiles between the P. italicum and P. digitatum transcriptomes.
DOI: 10.6084/m9.figshare.11846685
title: Additional file 2 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 2: Table S1. EC50 values of Pi-R and Pi-S against the fungicides belonging to DMI, benzimidazole and phenylpyrrole classes.
DOI: 10.6084/m9.figshare.11846685.v1
title: Additional file 2 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 2: Table S1. EC50 values of Pi-R and Pi-S against the fungicides belonging to DMI, benzimidazole and phenylpyrrole classes.
DOI: 10.6084/m9.figshare.11846691
title: Additional file 3 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 3: Table S2. Primers used in the present qRT-PCR validation.
DOI: 10.6084/m9.figshare.11846691.v1
title: Additional file 3 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 3: Table S2. Primers used in the present qRT-PCR validation.
DOI: 10.6084/m9.figshare.19711007.v1
title: Additional file 1 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 1: Supplementary Table S1: List and brief introduction of 2108 rice accessions used in this study.
DOI: 10.6084/m9.figshare.19711010
title: Additional file 2 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 2: Supplementary Table S2: Summary of SNPs associated significantly with glutinous detected in full population, indica and japonica by GWAS mapping.
DOI: 10.6084/m9.figshare.19711013.v1
title: Additional file 3 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 3: Supplementary Table S3: Thirty two candidate genes ovelapped in full population, indica, and japonica
DOI: 10.6084/m9.figshare.19711007
title: Additional file 1 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 1: Supplementary Table S1: List and brief introduction of 2108 rice accessions used in this study.
DOI: 10.6084/m9.figshare.19711010.v1
title: Additional file 2 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 2: Supplementary Table S2: Summary of SNPs associated significantly with glutinous detected in full population, indica and japonica by GWAS mapping.
DOI: 10.6084/m9.figshare.19711013
title: Additional file 3 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 3: Supplementary Table S3: Thirty two candidate genes ovelapped in full population, indica, and japonica
DOI: 10.6084/m9.figshare.19711016
title: Additional file 4 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 4: Supplementary Table S4: Expression analysis of candidate genes in full population, indica and japonica.
DOI: 10.6084/m9.figshare.19711016.v1
title: Additional file 4 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 4: Supplementary Table S4: Expression analysis of candidate genes in full population, indica and japonica.
DOI: 10.6084/m9.figshare.19711019
title: Additional file 5 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 5: Supplementary Table S5: SNPs used for haplotype analysis in three key genes.
DOI: 10.6084/m9.figshare.19711019.v1
title: Additional file 5 of Genome wide association study on development and evolution of glutinous rice

description: Additional file 5: Supplementary Table S5: SNPs used for haplotype analysis in three key genes.
DOI: 10.6084/m9.figshare.11846703
title: Additional file 5 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 5: Table S3. Summary of DEGs in the comparison between prochloraz-induced and no-induced Pi-R strains.
DOI: 10.6084/m9.figshare.11846703.v1
title: Additional file 5 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 5: Table S3. Summary of DEGs in the comparison between prochloraz-induced and no-induced Pi-R strains.
DOI: 10.6084/m9.figshare.11846706
title: Additional file 6 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 6: Table S4. Summary of DEGs in the comparison between prochloraz-induced and no-induced Pi-S strains.
DOI: 10.6084/m9.figshare.11846706.v1
title: Additional file 6 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 6: Table S4. Summary of DEGs in the comparison between prochloraz-induced and no-induced Pi-S strains.
DOI: 10.6084/m9.figshare.11846709
title: Additional file 7 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 7: Table S5. Summary of DEGs in the comparison between Pi-R and Pi-S strains under prochloraz-induced conditions.
DOI: 10.6084/m9.figshare.11846709.v1
title: Additional file 7 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 7: Table S5. Summary of DEGs in the comparison between Pi-R and Pi-S strains under prochloraz-induced conditions.
DOI: 10.6084/m9.figshare.11846715
title: Additional file 8 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 8: Table S6. Summary of DEGs in the comparison between Pi-R and Pi-S strains without prochloraz induction.
DOI: 10.6084/m9.figshare.11846715.v1
title: Additional file 8 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 8: Table S6. Summary of DEGs in the comparison between Pi-R and Pi-S strains without prochloraz induction.
DOI: 10.6084/m9.figshare.11846721
title: Additional file 9 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 9: Table S7. Summary of distribution (hit records) of 19 selected DEGs towards GO enrichments in the present 4 comparisons.
DOI: 10.6084/m9.figshare.11846721.v1
title: Additional file 9 of Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz

description: Additional file 9: Table S7. Summary of distribution (hit records) of 19 selected DEGs towards GO enrichments in the present 4 comparisons.
DOI: 10.6084/m9.figshare.19711046
title: Additional file 15 of EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway

description: Additional file 15.
DOI: 10.6084/m9.figshare.19711046.v1
title: Additional file 15 of EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway

description: Additional file 15.
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n.1
title: propargylbenzene
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: This is a physical chemical entity[CHEBI_24431] associated with a molecule[CHEBI_25367].
 The molecule[CHEBI_25367] can be described by the following structural desciptors[cheminf_000085]:
 InChI descriptor[cheminf_000113]: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2, and canonical SMILES descriptor[cheminf_000007]: C#CCc1ccccc1, and by the IUPAC name[cheminf_000107]: prop-2-ynylbenzene.
 
 The physical chemical entity[CHEBI_24431] has a component solvent[CHEBI_46787] which is described by the canonical SMILES descriptor[cheminf_000007]:
 
 The physical chemical entity[CHEBI_24431] has the following Sample ID as registered in the research data repository chemotion (www.chemotion-repository.net, https://doi.org/10.25504/FAIRsharing.iagXcR): CRS-38772

 The physical chemical entity[CHEBI_24431] can be described by the physical descriptors [CHEMINF_000025]:
 Melting point descriptor[CHEMINF_000256]: 
 Boiling point descriptor[CHEMINF_000257]: 
 Refractive index descriptor[CHEMINF_000253]:

 The physical chemical entity[CHEBI_24431] can be further described by the following assays[OBI:0000070][CHMO:0001133]:
 
 CHMO:0001146 | 1H--13C heteronuclear single quantum coherence (1H-13C HSQC)
 
 CHMO:0001148 | 1H--13C heteronuclear multiple bond coherence (13C-1H HMBC)
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 CHMO:0001150 | 1H--1H correlation spectroscopy (1H-1H COSY)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000595 | 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 CHMO:0000593 | 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 The physical chemical entity[CHEBI_24431] was deposited to the Molecule Archive of the Karlsruhe Insitute of Technology (KIT) with the following Sample ID: 

 Used ontologies:
 CHEBI - Chemical Entities of Biological Interest
 CHEMINF - chemical information ontology (information entities about chemical entities)
 CHMO - Chemical Methods Ontology
 OBI - Ontology for Biomedical Investigations
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0001146
title: 1H--13C heteronuclear single quantum coherence (1H-13C HSQC) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 1H--13C heteronuclear single quantum coherence (1H-13C HSQC)
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0000593
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, Chloroform-d [7.26 ppm], ppm) δ = 7.37–7.31 (m, 4H), 7.25–7.23 (m, 1H), 3.62 (d, J = 2.3 Hz, 2H), 2.19 (t, J = 2.6 Hz, 1H).
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0000593.1
title: 1H nuclear magnetic resonance spectroscopy (1H NMR) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 1H nuclear magnetic resonance spectroscopy (1H NMR)
 
 1H NMR (400 MHz, DMSO-d6 [2.50 ppm], ppm) δ = 7.34–7.32 (m, 4H), 7.27–7.22 (m, 1H), 3.62 (d, J = 2.7 Hz, 2H), 3.05 (t, J = 2.8 Hz, 1H).
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0001150
title: 1H--1H correlation spectroscopy (1H-1H COSY) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 1H--1H correlation spectroscopy (1H-1H COSY)
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0000595.1
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, DMSO-d6 [39.5 ppm], ppm) δ = 136.3, 128.4 (2C), 127.7 (2C), 126.5, 82.4, 73.0, 23.8.
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0000595
title: 13C nuclear magnetic resonance spectroscopy (13C NMR) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 13C nuclear magnetic resonance spectroscopy (13C NMR)
 
 13C NMR (100 MHz, Chloroform-d [77.2 ppm], ppm) δ = 136.2, 128.7 (2C), 128.0 (2C), 126.9, 82.1, 70.6, 25.0.
DOI: 10.14272/ngkskvywpingli-uhfffaoysa-n/chmo0001148
title: 1H--13C heteronuclear multiple bond coherence (13C-1H HMBC) (prop-2-ynylbenzene)
title: InChI=1S/C9H8/c1-2-6-9-7-4-3-5-8-9/h1,3-5,7-8H,6H2

description: dataset for 1H--13C heteronuclear multiple bond coherence (13C-1H HMBC)
DOI: 10.6084/m9.figshare.19711114
title: Additional file 5 of SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner

description: Additional file 5: Table S5. The DEGs between 17 human CRC tissue sample data sets and 17 normal tissue sample data sets in the Gene Expression Omnibus (GEO) database.
DOI: 10.6084/m9.figshare.19711114.v1
title: Additional file 5 of SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner

description: Additional file 5: Table S5. The DEGs between 17 human CRC tissue sample data sets and 17 normal tissue sample data sets in the Gene Expression Omnibus (GEO) database.
DOI: 10.6084/m9.figshare.12895428
title: Contrast-enhanced ultrasound-guided feeding artery ablation as add-on to percutaneous radiofrequency ablation for hypervascular hepatocellular carcinoma with a modified ablative technique and tumor perfusion evaluation

description: To establish a modified strategy of the feeding artery ablation (FAA) procedure as an add-on to percutaneous radiofrequency ablation (RFA) for patients with hypervascular hepatocellular carcinoma (HCC), and to evaluate the outcomes. For this prospective, single-arm study, from June 2014 to August 2016, twenty-five patients with hypervascular HCC, 2–5 cm in diameter were treated by contrast-enhanced ultrasound (CEUS)-guided FAA before conventional RFA. Technical success of FAA and subsequent perfusion change of the tumor were evaluated by CEUS. Technical efficacy and ablation sizes were evaluated by CT/MRI at 1 month. Therapeutic outcomes, including local tumor progression (LTP), overall survival (OS), and recurrence-free survival (RFS) were evaluated using the Kaplan–Meier method. One or two target feeding arteries were visible on CEUS for 52.6% (61/116) of the hypervascular HCCs 2–5 cm in diameter. The technical success rate of the FAA was 100%; 13/25 (52.0%) target tumors were evaluated as complete perfusion response, while 12/25 (48.0%) were evaluated as partial perfusion response. The ablation volume was 41.9 ± 17.5 cm<sup>3</sup> (14.9–78.2 cm<sup>3</sup>) and the ablative safety margin was 8.2 ± 1.9 mm (4–12 mm) at the 1-month evaluation. These parameters did not differ significantly between the complete and partial subgroups. The cumulative rates of LTP at 1-, 2-, and 3-year follow-ups were 0.0%, 4.2% and 4.2%, respectively. The 3-year OS and RFS were 70.3% vs. 59.8%, respectively. There were no treatment-related deaths. Major complications occurred in one patient (4.0%). As an add-on to conventional percutaneous RFA, tailored CEUS-guided FAA can reduce tumor perfusion and provide good local control of HCC.