cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.12852294.v1
title: A simple and improved score confidence interval for a single proportion

description: Confidence interval (CI) for a proportion has been a topic discussed repeatedly in the literature because of its omnipresence in applications. A wide variety of CIs have been proposed since the Wald CI for a proportion performs quite poorly. Among them, the Wilson score interval is widely recommended. However, the Wilson score method suffers from the so-called “downward spikes” when the proportion is close to 0 or 1. Except for the exact methods which ensure the coverage probability be at least the nominal size, the performances of existing proposed methods are similar to the Wilson score CI or its slightly improved version at the cost of increased interval width or computational complexity. In this study, we propose a simple CI which has very good performance in the coverage probability, confidence width, and the location. Especially when the proportion is &lt;20% or &gt;80% the CI proposed has a shorter confidence width than the Wilson score method. In combination our new method with the Newcombe’s hybrid way to construct CI for the difference of two independent proportions, we also get a better CI.
DOI: 10.6084/m9.figshare.12852513
title: Impact of environmental shocks on the preferred number of children of internal migrants: Evidence from China

description: Most research has used individual or group features to explain why migrants have different preferred number of children. However, these features can be identified and subdivided infinitely, with none of them broadly answering the question “why migrants desire more or less children”? This paper identified “environmental shocks”, which are a common experience for all migrants, as determinants of dissimilar preferred number of children across internal migrants in China. Environmental shocks refer to the uncertainty experienced by physical and sociocultural changes in the environment. Environmental shocks were treated as a variable rather than a constant in the analysis because shocks may differ between migrants. By sampling the 1667 internal migrants who participated in China’s 2015 General Social Survey, a quantitative analysis revealed that a farther migration distance (meaning greater environmental shocks) leads to lower preferred number of children for migrants. However, the mitigation of environmental shocks by the period at the current residence has no significant influence. Semi-structured interviews conducted with internal migrants in China revealed that the time since migration could mitigate environmental shocks and increase desired number of children, but the time since migration brings other challenges that may decrease preferred number of children. This study improves our understanding of the determinants of migrants’ childbearing willingness and suggests that the government need to help weaken the impact of environmental shocks and uncertainties on migrants to prevent their preferred number of children from decreasing.
DOI: 10.6084/m9.figshare.12852513.v1
title: Impact of environmental shocks on the preferred number of children of internal migrants: Evidence from China

description: Most research has used individual or group features to explain why migrants have different preferred number of children. However, these features can be identified and subdivided infinitely, with none of them broadly answering the question “why migrants desire more or less children”? This paper identified “environmental shocks”, which are a common experience for all migrants, as determinants of dissimilar preferred number of children across internal migrants in China. Environmental shocks refer to the uncertainty experienced by physical and sociocultural changes in the environment. Environmental shocks were treated as a variable rather than a constant in the analysis because shocks may differ between migrants. By sampling the 1667 internal migrants who participated in China’s 2015 General Social Survey, a quantitative analysis revealed that a farther migration distance (meaning greater environmental shocks) leads to lower preferred number of children for migrants. However, the mitigation of environmental shocks by the period at the current residence has no significant influence. Semi-structured interviews conducted with internal migrants in China revealed that the time since migration could mitigate environmental shocks and increase desired number of children, but the time since migration brings other challenges that may decrease preferred number of children. This study improves our understanding of the determinants of migrants’ childbearing willingness and suggests that the government need to help weaken the impact of environmental shocks and uncertainties on migrants to prevent their preferred number of children from decreasing.
DOI: 10.6084/m9.figshare.14746662
title: Additional file 1 of Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy

description: Additional file 1. ICP1: original data.
DOI: 10.6084/m9.figshare.14746662.v1
title: Additional file 1 of Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy

description: Additional file 1. ICP1: original data.
DOI: 10.6084/m9.figshare.14746677
title: Additional file 6 of Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy

description: Additional file 6. Hepatitis B virus: original data
DOI: 10.6084/m9.figshare.14746677.v1
title: Additional file 6 of Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy

description: Additional file 6. Hepatitis B virus: original data
DOI: 10.6084/m9.figshare.7243829
title: MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts

description: Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression levels of miR-221 in the different groups were measured by qRT-PCR. Then, miR-221 mimic and inhibitor were transfected into MC3T3-E1 cells, and cell viability and migration were measured using the CCK-8 assay and the Transwell migration assay. Additionally, the expression levels of differentiation-related factors (Runx2 and Ocn) and ZFPM2 were measured by qRT-PCR. Western blot was used to measure the expression of cell cycle-related proteins, epithelial-mesenchymal transition (EMT)-related proteins, ZFPM2, and Wnt/Notch, and Smad signaling pathway proteins. miR-221 was significantly up-regulated in the patients with lumbar compression fracture (LCM) and trochanteric fracture (TF). miR-221 promoted ALP, Runx2, and OPN expressions in MC3T3-E1 cells. miR-221 overexpression significantly increased cell proliferation, migration, differentiation, and matrix mineralization, whereas suppression of miR-221 reversed these effects. Additionally, the results displayed that ZFPM2 was a direct target gene of miR-221, and overexpression of ZFPM2 reversed the promoting effects of miR-221 overexpression on osteoblasts. Mechanistic study revealed that overexpression of miR-221 inactivated the Wnt/Notch and Smad signaling pathways by regulating ZFPM2 expression. We drew the conclusions that miR-221 overexpression promoted osteoblast proliferation, migration, and differentiation by regulation of ZFPM2 expression and deactivating the Wnt/Notch and Smad signaling pathways.
DOI: 10.6084/m9.figshare.7243829.v1
title: MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts

description: Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression levels of miR-221 in the different groups were measured by qRT-PCR. Then, miR-221 mimic and inhibitor were transfected into MC3T3-E1 cells, and cell viability and migration were measured using the CCK-8 assay and the Transwell migration assay. Additionally, the expression levels of differentiation-related factors (Runx2 and Ocn) and ZFPM2 were measured by qRT-PCR. Western blot was used to measure the expression of cell cycle-related proteins, epithelial-mesenchymal transition (EMT)-related proteins, ZFPM2, and Wnt/Notch, and Smad signaling pathway proteins. miR-221 was significantly up-regulated in the patients with lumbar compression fracture (LCM) and trochanteric fracture (TF). miR-221 promoted ALP, Runx2, and OPN expressions in MC3T3-E1 cells. miR-221 overexpression significantly increased cell proliferation, migration, differentiation, and matrix mineralization, whereas suppression of miR-221 reversed these effects. Additionally, the results displayed that ZFPM2 was a direct target gene of miR-221, and overexpression of ZFPM2 reversed the promoting effects of miR-221 overexpression on osteoblasts. Mechanistic study revealed that overexpression of miR-221 inactivated the Wnt/Notch and Smad signaling pathways by regulating ZFPM2 expression. We drew the conclusions that miR-221 overexpression promoted osteoblast proliferation, migration, and differentiation by regulation of ZFPM2 expression and deactivating the Wnt/Notch and Smad signaling pathways.
DOI: 10.6084/m9.figshare.6561110
title: MOESM6 of Disruption of gul-1 decreased the culture viscosity and improved protein secretion in the filamentous fungus Neurospora crassa

description: Additional file 6: Table S2. Gene list of the 246 genes differentially expressed in Î gul-1 as compared to WT on Avicel.
DOI: 10.6084/m9.figshare.6561110.v1
title: MOESM6 of Disruption of gul-1 decreased the culture viscosity and improved protein secretion in the filamentous fungus Neurospora crassa

description: Additional file 6: Table S2. Gene list of the 246 genes differentially expressed in Î gul-1 as compared to WT on Avicel.
DOI: 10.6084/m9.figshare.12852624
title: Factors influencing existing medium-sized commercial building energy retrofits to achieve the net zero energy goal in the United States

description: Despite the increased awareness of benefits and opportunities resulting from energy retrofits, there is a lack of information regarding the factors influencing the success of energy retrofits – especially deep energy retrofits – aiming to achieve a net zero energy goal. The aim of this study is to identify factors and variables that could contribute to the successful implementation of energy retrofit measures in buildings with the goal of achieving net zero energy. A database of 34 small- and medium-sized commercial building retrofit projects was developed for this analysis, which was derived from the New Buildings Institute’s Net Zero Energy Building Database. Five factor categories were investigated: physical, technical, environmental, economic, and policy. A total of 11 variables from the 5 categories were analysed. The results show that success stems from a combination of certain variables: the number of floors, the climate zone, and the building cost. In general, the results indicate a trend: compact buildings with a construction cost range between $19/m<sup>2</sup> and $42/m<sup>2</sup> in a mild climate have a higher likelihood of achieving a net zero energy goal. Also, the analysis provides new evidence toward the importance of understanding a building’s physical characteristics in an existing building energy retrofit.
DOI: 10.6084/m9.figshare.12852624.v1
title: Factors influencing existing medium-sized commercial building energy retrofits to achieve the net zero energy goal in the United States

description: Despite the increased awareness of benefits and opportunities resulting from energy retrofits, there is a lack of information regarding the factors influencing the success of energy retrofits – especially deep energy retrofits – aiming to achieve a net zero energy goal. The aim of this study is to identify factors and variables that could contribute to the successful implementation of energy retrofit measures in buildings with the goal of achieving net zero energy. A database of 34 small- and medium-sized commercial building retrofit projects was developed for this analysis, which was derived from the New Buildings Institute’s Net Zero Energy Building Database. Five factor categories were investigated: physical, technical, environmental, economic, and policy. A total of 11 variables from the 5 categories were analysed. The results show that success stems from a combination of certain variables: the number of floors, the climate zone, and the building cost. In general, the results indicate a trend: compact buildings with a construction cost range between $19/m<sup>2</sup> and $42/m<sup>2</sup> in a mild climate have a higher likelihood of achieving a net zero energy goal. Also, the analysis provides new evidence toward the importance of understanding a building’s physical characteristics in an existing building energy retrofit.
DOI: 10.3886/e193684v1-146221
title: Data and Code for: Why Did the Best Prepared Country in the World Fare So Poorly During COVID?

description: These files contain the programs and data for the journal article
“Why Did the Best Prepared Country in the World Fare So Poorly During COVID?”
description: NA
description: Response Rates: NA
description: NA
description: country-level. Smallest Geographic Unit: country-level
description: other;
DOI: 10.5281/zenodo.10663904
title: "Excited-state dynamics of isolated and (micro)solvated methyl sinapate: the bright and shady sides of a natural sunscreen" dataset
DOI: 10.5281/zenodo.10663905
title: "Excited-state dynamics of isolated and (micro)solvated methyl sinapate: the bright and shady sides of a natural sunscreen" dataset
DOI: 10.6084/m9.figshare.17047146
title: Additional file 1 of Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

description: Additional file 1: Table S1. The results of GO functional enrichment analysis of 9 modules.
DOI: 10.6084/m9.figshare.17047146.v1
title: Additional file 1 of Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

description: Additional file 1: Table S1. The results of GO functional enrichment analysis of 9 modules.
DOI: 10.6084/m9.figshare.17047149
title: Additional file 2 of Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

description: Additional file 2: Table S2. The results of pathway functional enrichment analysis of 9 modules.
DOI: 10.6084/m9.figshare.17047149.v1
title: Additional file 2 of Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

description: Additional file 2: Table S2. The results of pathway functional enrichment analysis of 9 modules.
DOI: 10.6084/m9.figshare.17047155
title: Additional file 3 of Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

description: Additional file 3: Table S3. The number of the primary interaction pairs of lncRNA-miRNA and the secondary interaction pairs of miRNA-gene.
DOI: 10.6084/m9.figshare.17047155.v1
title: Additional file 3 of Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

description: Additional file 3: Table S3. The number of the primary interaction pairs of lncRNA-miRNA and the secondary interaction pairs of miRNA-gene.
DOI: 10.6084/m9.figshare.17047178
title: Additional file 2 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 2.
DOI: 10.6084/m9.figshare.17047181
title: Additional file 3 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 3.
DOI: 10.6084/m9.figshare.17047181.v1
title: Additional file 3 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 3.
DOI: 10.6084/m9.figshare.17047187.v1
title: Additional file 5 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 5.
DOI: 10.6084/m9.figshare.17047178.v1
title: Additional file 2 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 2.
DOI: 10.6084/m9.figshare.17047184
title: Additional file 4 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 4.
DOI: 10.6084/m9.figshare.17047184.v1
title: Additional file 4 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 4.
DOI: 10.6084/m9.figshare.17047187
title: Additional file 5 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 5.
DOI: 10.6084/m9.figshare.17047190
title: Additional file 6 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 6.
DOI: 10.6084/m9.figshare.17047190.v1
title: Additional file 6 of The web-based multiplex PCR primer design software Ultiplex and the associated experimental workflow: up to 100- plex multiplicity

description: Additional file 6.
DOI: 10.6084/m9.figshare.11804328
title: Dynamic stress analysis of anisotropic gun barrel under coupled thermo-mechanical loads via finite element method

description: Abstract This work focused on the stress response of anisotropic 30SiMn2MoVA steel gun barrel under coupled thermo-mechanical loads, namely, the contact pressure and friction of projectile, thermal load and pressure of propellant gas. The effect of temperature on the mechanical properties of gun barrel was considered. Two thermal-displacement coupled finite element models (FEM) were built by ABAQUS software. The first was the interaction model of projectile and barrel which was to calculate the stress of barrel engraved by copper jacket and steel jacket projectile. The results of barrel in the interaction model, as an initial condition, were imported to the second FEM which was applied with thermal load and pressure of propellant gas. The results show that the rifling at chamber throat has the largest stress and circumferential stress under coupled loads. It gives a request that the gun barrel should have the better circumferential mechanical properties. The plastic deformation of the rifling at the chamber throat is observed which indicates that 30SiMn2MoVA gun barrel has a low service life due to the poor mechanical properties.
DOI: 10.6084/m9.figshare.11804328.v1
title: Dynamic stress analysis of anisotropic gun barrel under coupled thermo-mechanical loads via finite element method

description: Abstract This work focused on the stress response of anisotropic 30SiMn2MoVA steel gun barrel under coupled thermo-mechanical loads, namely, the contact pressure and friction of projectile, thermal load and pressure of propellant gas. The effect of temperature on the mechanical properties of gun barrel was considered. Two thermal-displacement coupled finite element models (FEM) were built by ABAQUS software. The first was the interaction model of projectile and barrel which was to calculate the stress of barrel engraved by copper jacket and steel jacket projectile. The results of barrel in the interaction model, as an initial condition, were imported to the second FEM which was applied with thermal load and pressure of propellant gas. The results show that the rifling at chamber throat has the largest stress and circumferential stress under coupled loads. It gives a request that the gun barrel should have the better circumferential mechanical properties. The plastic deformation of the rifling at the chamber throat is observed which indicates that 30SiMn2MoVA gun barrel has a low service life due to the poor mechanical properties.
DOI: 10.6084/m9.figshare.17047214
title: Additional file 10 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 10.
DOI: 10.6084/m9.figshare.17047214.v1
title: Additional file 10 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 10.
DOI: 10.6084/m9.figshare.17047217
title: Additional file 11 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 11.
DOI: 10.6084/m9.figshare.17047217.v1
title: Additional file 11 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 11.
DOI: 10.6084/m9.figshare.17047220
title: Additional file 12 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 12.
DOI: 10.6084/m9.figshare.17047220.v1
title: Additional file 12 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 12.
DOI: 10.6084/m9.figshare.17047232
title: Additional file 4 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 4.
DOI: 10.6084/m9.figshare.17047232.v1
title: Additional file 4 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 4.
DOI: 10.6084/m9.figshare.17047235
title: Additional file 5 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 5.
DOI: 10.6084/m9.figshare.17047235.v1
title: Additional file 5 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 5.
DOI: 10.6084/m9.figshare.17047238
title: Additional file 6 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 6.
DOI: 10.6084/m9.figshare.17047238.v1
title: Additional file 6 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 6.
DOI: 10.6084/m9.figshare.17047241
title: Additional file 7 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 7.
DOI: 10.6084/m9.figshare.17047241.v1
title: Additional file 7 of Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.)

description: Additional file 7.
DOI: 10.6084/m9.figshare.17047242
title: Additional file 3 of Explore association of genes in PDL1/PD1 pathway to radiotherapy survival benefit based on interaction model strategy

description: Additional file 3. Table S1: 73 genes in “PD-L1 expression and PD-1 checkpoint pathway in cancer”.