cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.28295207.v1
title: Supplementary Material for: CC genotype at TCF7L2 diabetes risk locus rs7903146 directs a coordinated fatty acid response to a Mediterranean diet intervention: a randomized controlled trial

description: Introduction. Previous studies identified genetic links between the TCF7L2 C/T variant rs7903146, type 2 diabetes (T2D), and obesity. We wished to deepen our understanding of how specific diets interact with this variant to affect blood metabolites, an aspect not previously investigated. Hence, we conducted a controlled study where individuals with different genotypes followed a Mediterranean (Med) or low-fat (LF) diet for one week.
Methods. Participants were recruited from the Boston, MA (USA) area. Anthropometric and clinical measures were taken. Genotypes at rs7903146 were ascertained, with homozygous carriers of the more common and protective CC or risk TT genotype invited to participate. Participants followed both diets (LF or Med) for one week with ~10 days’ washout between diets. Blood samples taken at the beginning and end of each diet period underwent metabolomics analysis using nuclear magnetic resonance spectroscopy. We evaluated how the diet affected different metabolites based on genetic profile.
Results. The cohort of 35 persons was 43% female, aged 18 to 70 y, with BMI between 26.4 to 33.9 kg/m2. Focusing on fatty acids (FAs) and other lipid metabolic factors (n = 23), we observed a greater number and stronger correlations among these factors in the CC genotype-Med diet group than the other three genotype-diet combinations. An aggregate of 11 factors, each negatively correlating with delta saturated fatty acids (SFA), showed a significant genotype-Med diet interaction on delta-SFA in CC individuals on the Med diet (p = 0.0046). A similar genotype-Med diet interaction was observed for delta-monounsaturated fatty acids (MUFA) (p = 0.0078). These interactions were not statistically significant at the end of the LF intervention.
Conclusion. Our findings suggest that the Mediterranean diet has stronger influence on regulating lipid factors in individuals with the CC genotype at TCF7L2 variant rs7903146. This diet-genotype interaction may have significant implications for understanding the inter-individual variation of metabolic response on specific dietary regimens.
DOI: 10.6084/m9.figshare.22325833.v1
title: Late remdesivir treatment initiation partially protects African green monkeys from lethal Nipah virus infection

description: Remdesivir is a nucleotide prodrug with preclinical efficacy against lethal Nipah virus infection in African green monkeys when administered 1 day post inoculation (dpi). Here, we determined whether remdesivir treatment was still effective when treatment administration initiation was delayed until 3 dpi. Three groups of six African green monkeys were inoculated with a lethal dose of Nipah virus, Bangladesh. On 3 dpi, one group received a loading dose of 10mg/kg remdesivir followed by daily dosing with 5mg/kg for 11 days, one group received 10mg/kg on 12 consecutive days, and the remaining group received an equivalent volume of vehicle solution. Remdesivir treatment initiation on 3 dpi provided partial protection from severe Nipah virus disease that was dose dependent, with 67% of animals in the high dose group surviving the challenge. However, remdesivir treatment did not prevent clinical disease, and surviving animals showed histologic lesions in the brain. Thus, early administration seems critical for effective remdesivir treatment during Nipah virus infection.
DOI: 10.6084/m9.figshare.7913816.v1
title: gVCF_HG03646

description: 1000 Genomes gVCF mapped to hs37d5 for HG03646. Complete collection: https://doi.org/10.6084/m9.figshare.c.4414307
DOI: 10.6084/m9.figshare.22640197.v1
title: Experimental data.xlsx

description: Data set for the manuscript of The sorption behaviors of barium during reinjection of gas field produced water into sandstone reservoir: An experimental water-rock interaction study
DOI: 10.6084/m9.figshare.24103443.v1
title: XRD j constant.xlsx

description: the data describe the relation between the wavelength and the intensity of light
DOI: 10.6084/m9.figshare.28887449.v1
title: LTL331_scRNA_seq_Metadata

description: Neuroendocrine transdifferentiation (NEtD) of prostate adenocarcinoma (PRAD) leads to aggressive neuroendocrine prostate cancer (NEPC). The LTL331 patient-derived xenograft (PDX) model consistently progresses to NEPC following castration, mimicking clinical responses to androgen-deprivation therapy. Here we tracked NEtD using longitudinal single-cell RNA sequencing (scRNA-seq) across eight time points in LTL331 from pre- to post-castration. Castration led to the loss of AR-high PRAD cells, expansion of AR-low populations, and emergence of an AR- and NE-negative (AR-/NE-) intermediate state that transitioned into NEPC. We delineate a model in which pre-EMT cells enriched in ciliogenesis and cell-adhesion pathways differentiate into EMT-like populations before branching into distinct ASCL1+ and ASCL1− NEPC states. The EMTenriched intermediate, marked by progenitor and neural crest stem-cell genes, acts as a transition bridge, suggesting EMT-associated stemness underlies lineage plasticity. A terminal ASCL1- NEPC state also suggests that ASCL1 is not essential for NEPC maintenance. Gene regulatory analysis highlighted key regulators driving NEtD, including MSX1 and ASCL1 in early EMT-like and NEPC states, respectively. These transcriptional states were validated in both patient-derived bulk and scRNA-seq data. Our findings offer insights into intervention strategies to delay or prevent NEtD with the potential of identifying novel prognostic and therapeutic targets
DOI: 10.17632/pbv8pdv3mj
title: Supplemental Tables

description: Supplemental Tables for "Characterizing Low-Dose Oral Minoxidil-Induced Peripheral Edema in Alopecia Patients" in JAAD.
DOI: 10.17632/swx8wtfj44
title: Data for: Swelling Pressure of Montmorillonite with Multiple Water Layers at Elevated Temperatures and Water Pressures: A Molecular Dynamics Study

description: This file includes swelling pressure data shown in Figure 2-4.
DOI: 10.6084/m9.figshare.19508752.v1
title: Contrasting modes of macro- and micro-synteny evolution in a eukaryotic subphylum

description: 120 budding yeast genome assemblies and annotations, synteny analysis, phylogenetic trees, network analysis, additional figures and tables, scripts used in this study are available on the Figshare data repository
DOI: 10.6084/m9.figshare.1124217.v2
title: Response to Castellani - Raw data- ClinicalTrials.gov records- Completed - Interventional Studies - United States - Phase 3 - received from 01-01-2002 to 01-01-2014

description: Response to Castellani - Raw data- ClinicalTrials.gov records- Completed - Interventional Studies - United States - Phase 3 - received from 01-01-2002 to 01-01-2014 This database complies with the terms and conditions of ClinicalTrials.gov: http://clinicaltrials.gov/ct2/about-site/terms-conditions ----- "an ounce of data is worth a thousand pounds of opinion." (1) 1. Unpublished US phase 3 trials. Infographics: Raw data: 2. About the 8 novel drugs approved by the FDA in 2013 3. It's relatively easy to disclose anonymized patient level raw data of a clinical trial. 4. About patient privacy concerns: could anyone identify at least one patient recruited in this clinical trial? References 1. Ashish Jha. An Ounce of Evidence. Health Policy Blog. Harvard University.<br>URL: http://blogs.sph.harvard.edu/ashish-jha/<br>Date accessed: Aug 13, 2014 2. Ramirez JH, Arce R, Contreras A, et al. Periodontal therapy does not improve cardiovascular disease biomarkers: results of a randomized clinical trial. figshare.<br>http://dx.doi.org/10.6084/m9.figshare.1098548
DOI: 10.6084/m9.figshare.23628450.v1
title: Air-writing digits.zip

description: Air-writing digits based on FMCW radar
DOI: 10.6084/m9.figshare.28450643.v1
title: Urban and Periurban Forests of Italy: Structure, Tree-related Microhabitats, and Deadwood

description: The dataset consists of a total of 180 plots, sampled across three Italian urban areas: Firenze, Roma, and Campobasso. Within each urban area, four distinct locations were selected, with 15 in-situ plots sampled at each site. The plots were arranged along a gradient from urban to peri-urban environments, as follows:<b>Firenze</b>: Giardino di Boboli, Parco delle Cascine, Villa Medicea della Petraia, Villa Demidoff - Parco Mediceo di Pratolino;<b>Roma</b>: Villa Borghese, Villa Ada Savoia, Villa Doria Pamphilj, Riserva Naturale di Decima Malafede;<b>Campobasso</b>: Villa De Capoa, Rocca Monforte, Parco dello Scarafone, Monte Vairano.Per each plot, information regarding (i) forest structure, (ii) tree-related microhabitats, and (iii) deadwood characteristics were collected.
DOI: 10.6084/m9.figshare.12129303.v11
title: Source code for: Estimation of waste outflows for multiple product types in China from 2010-2050

description: In order to ensure the replicability and reproducibility of our dataset, we share here all codes that were developed for producing this dataset excel. The dataset will be updated regularly in the future.This collection includes: (1) D1-D3: Statistics of domestic production for EEE, vehicle, and wiring & cable in China(2) D4: Statistics of three types of product importation and exportation in China(3) D5: Weights of each product and those data distributions(4) F1 Regression simulation equation for consumption (5) D6-D8: Product consumption amount in 1990-2050(6) D9: Parameters of Weibull lifespan distribution and the regulated maximum lifetime(7) D10: WEEE generation inventory in 2010-2050(8) D11: ELV generation inventory in 2010-2050(9) D12: WWC weight generation inventory in 2010-2050
DOI: 10.6084/m9.figshare.14572665.v1
title: Supplementary Material for: Platelet Transfusion and Outcomes of Preterm Infants: A Cross-Sectional Study

description: <b><i>Background:</i></b> Prophylactic platelet transfusion has been adopted as a ubiquitous practice in management of thrombocytopenia in preterm infants to reduce the risk of bleeding. <b><i>Objectives:</i></b> The objectives of this study were to report the prevalence of platelet transfusion among preterm infants with thrombocytopenia and to assess the association of platelet transfusion with mortality and morbidity in this population. <b><i>Methods:</i></b> A cross-sectional study that utilized National Inpatient Sample for the years 2000–2017 was conducted. All preterm infants delivered nationally with birth weight (BW) &lt;1,500 g or gestational age &lt;32 weeks were included. Analyses were repeated after stratifying the population into 2 BW subcategories &lt;1,000 g and 1,000–1,499 g. Logistic regression analysis was performed to adjust for confounding variables. <b><i>Results:</i></b> The study included 1,780,299 infants; of them, 22,609 (1.27%) were diagnosed with thrombocytopenia and 5,134 (22.7%) received platelet transfusion. Platelet transfusion was associated with significant increase in mortality (24.8 vs. 13.8%), retinopathy of prematurity (22.3 vs. 19.2%), severe intraventricular hemorrhage (18.3 vs. 10.1%), median length of hospital stays (51 vs. 47 days), and cost of hospitalization (USD 298,204 vs. USD 219,760). Increased mortality was noted in &lt;1,000-g infants (aOR = 1.96, CI: 1.76–2.18, <i>p</i> &lt; 0.001) and 1,000–1,499-g infants (aOR = 2.02, CI: 1.62–2.53, <i>p</i> &lt; 0.001). Platelet transfusion increased over the years in infants with BW &lt;1,000 g (<i>p</i> = 0.001) and in infants with BW 1,000–1,499 g (<i>p</i> &lt; 0.001). <b><i>Conclusions:</i></b> Platelet transfusion is associated with increased mortality and comorbidities in premature infants. There is a trend for increased utilization of platelet transfusions over the study period.
DOI: 10.6084/m9.figshare.14825784.v3
title: Data for nontoxic Microcystis on Daphnia defense

description: data for nontoxic Microcystis on Daphnia defense
DOI: 10.6084/m9.figshare.3775821.v1
title: Publications linking biodiversity and ecosystem services 2001-2014

description: Dataset of 585 papers published between 2001 and 2014 that relate biodiversity and ecosystem services.<br>These data support Ricketts et al. 2016. <i>Nature Communications.</i> DOI 10.1038/NCOMMS13106. Search criteria to assemble the dataset and coding rules used to code attributes of each paper are described in that paper.
DOI: 10.6084/m9.figshare.24077871.v2
title: Genome assembly and annotation results

description: Genome assembly and annotation results
DOI: 10.6084/m9.figshare.20575902.v2
title: Letter of Credence from King George III to Emperor Qianlong (1793)

description: In the <em>Letter of Credence from King George III to Emperor Qianlong</em> (1793), the British king appealed to the Chinese emperor to expand the trade between Britain and China, establish a permanent embassy to the imperial court, and cede a small island for British residence. This letter has two translated Chinese versions. One is the Qing court version, translated by European missionaries serving in the Qing court and collected in <em>Majiaerni fanghua shiliao huibian</em> 马戛尔尼访华史料汇编 [Archives of Lord Macartney’s Embassy to China] (1996, 172-175); the other is the embassy version translated by Catholic priests (H. Wang, 2013b) and kept in the British National Archives (FO 1048/1) (H. Wang, 2020, p. 13).
DOI: 10.6084/m9.figshare.14445582.v2
title: Structural and Electrical Resistivity Tomography datasets from "Volcano-tectonic setting of the Pisciarelli Fumarole Field, Campi Flegrei caldera, southern Italy: insights into fluid circulation patterns and hazard scenarios"

description: This dataset includes structural and electrical resistivity tomography (ERT) data collected in the Pisciarelli area (Campi Flegrei) and used for the research paper “Volcano-tectonic setting of the Pisciarelli Fumarole Field, Campi Flegrei caldera, southern Italy: insights into fluid circulation patterns and hazard scenarios” by R. Isaia, M.G. Di Giuseppe, J. Natale, F.D.A. Tramparulo, A. Troiano, S. Vitale, in review to Tectonics.<br>The dataset is organized into 2 files:1)ERT dataset contains the field data resistance (V/I) of three electrical resistivity profiles (A, B and C) and configuration information (the electrode ID's for each of the four quadrupole electrodes).2) Structural dataset contains the analyzed structural features, including orientation and spatial position of: mesoscale S1 and S2 faults system and the fractures measured in the study area
DOI: 10.6084/m9.figshare.28435262.v1
title: John Cormican Thesis Supplementary Material

description: This contains supplementary files relevant to my thesis submission.
DOI: 10.6084/m9.figshare.9643010.v1
title: fMRI data for 23 subjects with conversion from MCI to Dementia

description: fMRI data for 23 subjects with conversion from MCI to Dementia. The data is used in the real data analysis of the paper "Paired Test of Matrix Graphs and Brain Connectivity Analysis."
DOI: 10.6084/m9.figshare.22566592.v1
title: Table 1.tif

description: <strong>the profit functions of three pre-sale strategies</strong>
DOI: 10.17632/882hhft2pf
title: Data Note of Parenting Stress, Resilience, Religiosity, and Emotional Competence in Caregivers of Children with Special Needs

description: The title of research is Parenting Stress, Resilience, Religiosity, and Emotional Competence in Caregivers of Children with Special Needs. This study was based on cross sectional study with a correlational quantitative approach. This data noted explains in detail the data used in the research, which includes collecting participant data, as well as the results of validity and reliability tests for each variable, and all of results measurement.
DOI: 10.6084/m9.figshare.16715578.v1
title: Laboratory measurement of wave-current ripple development

description: Large-scale flume experiments were conducted in the Total Environment Simulator at the University of Hull in order to study ripple dynamics in mixed sand–clay substrates under combined flows. This dataset provides detailed information of wave-current ripple development, recording by Ultrasonic Range System (URS), from beds with the initial clay content between 0% and 12.3%. In addition, the results of grain size analysis, using Malvern Mastersizer 2000, from sediment cores collected during the experiments are included, showing vertical change in clay content with ripple evolution. Moreover, hydrodynamic data including near-bed flow velocities monitored by Vectrino Profilers and water surface elevation recorded by acoustic water level sensors are also in the present dataset.
DOI: 10.17632/7vzs2gtgbj
title: Data for: Role of User’s Socio-Economic and Travel Characteristics in Mode Choice Between City Bus and Informal Transit Services: Lessons from Household Surveys in Visakhapatnam, India

description: The attached data set includes socio economic and travel characteristics data of formal public transport and paratransit users in Visakhapatnam, India
DOI: 10.6084/m9.figshare.20017477.v1
title: Determinant factors of efficiency when the Counter Movement Jump is performed in acute fatigue

description: This work analysed the changes that occur in kinetic-temporal parameters and the electromyographic activity of lower limb muscles during the performance of maximum Counter Movement Jumps (CMJ) done with and without muscular fatigue, to explain the changes in performance in both situations. The vertical strength of fifty jumps performed by ten male sportsmen before and after a fatigue protocol was registered. Records of surface electromyography were obtained for six lower limb muscles; in addition, activation level and intermuscular coordination were analysed. For analysis purposes, negative and positive mechanic working times were considered separately. In both conditions, the temporal course of strength distribution is more important for the performance than any other instantaneous parameter. The negative external working time was significantly lower in fatigue conditions. The electromyographic analysis showed an increase in the activation level of all muscles studied and significant changes in the activation sequence. The specific kinetic-temporal variables were not good predictors of jump height. When CMJ is performed without muscle fatigue, a high value of active state favours the positive work. During fatigue, there could be a partial compensation of the performance due to the increasing activity of the contractile elements, although the activation sequence undergoes significant changes. Thus, the changes in performance would be mainly associated with the decrease in the capacity to transmit power in the proximal-distal direction.
DOI: 10.17632/nhzr85fts6
title: IL-10-producing regulatory cells impact on Celiac Disease evolution

description: In the manuscript "IL-10-producing regulatory cells impact on celiac disease evolution" (doi: 10.1016/j.clim.2024.109923), we showed that IL-10-producing cells are fundamental in controlling pathological T-cell responses to gluten. In brief, our major findings are:
1) Gluten ingestion induces systemic inflammation in CD patients;
2) Gliadin-specific IFN-g+ T cells are present in patients regardless of tissue damage;
3) The presence of DC-10 in mucosal infiltrates is a hallmark of potential CD patients;
4) In potential CD, DC-10 maintain mucosal homeostasis and protect the gut from damage.
The datasets here loaded contain all the clinical and immunological data, supporting our conclusions, that have been used to build the manuscript.
An additional file (raw_data_description) contains the main guidelines to correctly associate the raw data with the corresponding figure/table in the manuscript.
DOI: 10.6084/m9.figshare.27281550.v1
title: Supplementary Material for: Development of an Artificial Intelligence System for Distinguishing Malignant from Benign Soft Tissue Tumors Using Contrast-Enhanced MR Images

description: Introduction: The integration of artificial intelligence (AI) into orthopedics has enhanced the diagnosis of various conditions; however, its use in diagnosing soft-tissue tumors remains limited owing to its complexity. This study aimed to develop and assess an AI-driven diagnostic support system for magnetic resonance imaging (MRI)-based soft-tissue tumor diagnosis, potentially improving accuracy and aiding radiologists and orthopedic surgeons.
Methods: Experienced orthopedic oncologists and radiologists annotated 720 images from 77 cases (41 benign and 36 malignant soft-tissue tumors). Eleven tumor subtypes were identified and classified into benign and malignant groups based on histological diagnosis. Utilizing the standard machine learning classifier pipeline, we examined and down-selected imaging protocols and their predominant radiomic features within the tumor's three-dimensional region to differentiate between benign and malignant tumors. Among the scan protocols, contrast-enhanced T1 weighted fat-suppressed images showed the most accurate classification based on radiomics features. We focused on the two-dimensional features from the largest tumor boundary surface and its neighboring slices, leveraging texture-based radiomic and deep convolutional neural network features from a pretrained VGG19 model.
Results: The test data comprised 44 contrast-enhanced images (22 benign and 22 malignant soft-tissue tumors) containing six malignant and five benign subtypes distinct from the training data. We compared expert and non-expert human performances against AI by assessing malignancy detection and the time required for classification. The AI model showed comparable accuracy (AUC 0.91) to that of radiologists (AUC 0.83) and orthopedic surgeons (AUC 0.73). Notably, the AI model processed data approximately 400 times faster than its human counterparts, showcasing its capacity to significantly boost diagnostic efficiency.
Conclusion: We developed an AI-driven diagnostic support system for MRI-based soft-tissue tumor diagnosis. While additional refinement is necessary for clinical applications, our system has exhibited promising potential in differentiating between benign and malignant soft-tissue tumors based on MRI.
DOI: 10.6084/m9.figshare.6453110.v2
title: An investigation of APA citation style skills of international students studying at Unitec Institute of Technology

description: Many university and polytechnic students in New Zealand are asked to use APA citation style in theirwriting assignments. However, a literature review on major works published in the last 10 years foundno studies examining how well New Zealand students handle APA style. Moreover, in my daily work inan academic library, I have noticed many of our students have difficulties in formatting papers usingAPA style.Taking a different approach, this research used a specifically designed test to probe for the mostcommon problems students face with formatting APA reference list and in-text citation. This approachwas based on the following considerations: (a) to facilitate a quantitative comparison and analysis ofeach APA element; (2) to verify this research approach, which was hardly used before. Special attentionwas paid to digital resources (e.g., blog post, video stream, etc.) to reflect a growing digital academicand research environment. Furthermore, this test has a strong focus on information resourcesrelevant to New Zealand.The research findings show that students’ APA style skills remained at the basic level. They had someideas about the rules, but did not comply with many of them. One significant finding is that theylacked the skills to judge the nature of information sources. Students generally performed well withthose information resources with which they are familiar. The research findings provide a snapshot onhow a sample of international students performed regarding APA style, and may inform the design ofa future APA style training session.