cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.26384070
title: Molecular docking, MD simulation, and MMGBSA-binding free energy estimation study identify antibiotic analogs as potential antimalarials targeting housekeeping proteins of <i>Plasmodium falciparum</i> apicoplast

description: <i>Plasmodium falciparum</i> exclusively harbours a non-photosynthetic plastid-like organelle called ‘apicoplast,’ crucial for survival. The apicoplast genome resembles chloroplasts, albeit much reduced at 35 kb. The housekeeping functions of the apicoplast are similar to prokaryotes, and several antibiotics have been reported to kill the malaria parasite by targeting its housekeeping functions. However, a significant structural difference between bacterial and apicoplast housekeeping proteins promotes the discovery of antibiotic analogs specifically targeting apicoplast proteins. In this study, we used a high-throughput virtual screening approach to analyze 80% of structurally similar antibiotic analog libraries against five protein targets, including histone-like protein (PfHU), gyrase A subunit (PfGyrA), RNA polymerase β subunit (PfRpoβ), elongation factor G (PfEF-G), and elongation factor Tu (PfEF-Tu) involved in different housekeeping functions of the apicoplast. This computational screening identified molecules with better binding affinities than those antibiotics shown to have antimalarial activities, suggesting they may be more potent antimalarial compounds. The molecular dynamics simulations study revealed stable conformational changes with strong hydrogen bonds between the protein–ligand complexes. The top-hit antibiotic analogs exhibit favourable drug-like characteristics, making them promising candidates for future clinical studies. We propose further biochemical and phenotypic testing of these antibiotic analogs to develop more effective apicoplast-targeting antimalarials.
DOI: 10.6084/m9.figshare.26384070.v1
title: Molecular docking, MD simulation, and MMGBSA-binding free energy estimation study identify antibiotic analogs as potential antimalarials targeting housekeeping proteins of <i>Plasmodium falciparum</i> apicoplast

description: <i>Plasmodium falciparum</i> exclusively harbours a non-photosynthetic plastid-like organelle called ‘apicoplast,’ crucial for survival. The apicoplast genome resembles chloroplasts, albeit much reduced at 35 kb. The housekeeping functions of the apicoplast are similar to prokaryotes, and several antibiotics have been reported to kill the malaria parasite by targeting its housekeeping functions. However, a significant structural difference between bacterial and apicoplast housekeeping proteins promotes the discovery of antibiotic analogs specifically targeting apicoplast proteins. In this study, we used a high-throughput virtual screening approach to analyze 80% of structurally similar antibiotic analog libraries against five protein targets, including histone-like protein (PfHU), gyrase A subunit (PfGyrA), RNA polymerase β subunit (PfRpoβ), elongation factor G (PfEF-G), and elongation factor Tu (PfEF-Tu) involved in different housekeeping functions of the apicoplast. This computational screening identified molecules with better binding affinities than those antibiotics shown to have antimalarial activities, suggesting they may be more potent antimalarial compounds. The molecular dynamics simulations study revealed stable conformational changes with strong hydrogen bonds between the protein–ligand complexes. The top-hit antibiotic analogs exhibit favourable drug-like characteristics, making them promising candidates for future clinical studies. We propose further biochemical and phenotypic testing of these antibiotic analogs to develop more effective apicoplast-targeting antimalarials.
DOI: 10.15468/dl.s9rebb
title: Occurrence Download

description: A dataset containing 34 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (China, Hong Kong, Macao)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Solanum rostratum Dunal"
 ]
}

 The dataset includes 34 records from 5 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013039-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xngg9s
title: Occurrence Download

description: A dataset containing 422 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is Chile",
 "TaxonKey is Nycticryphes semicollaris (Vieillot, 1816)"
 ]
}

 The dataset includes 422 records from 20 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013040-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.6dsnj2
title: Occurrence Download

description: A dataset containing 195 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is one of (Mongolia, Russian Federation, China)",
 "TaxonKey is one of (Saussurea dorogostaiskii Palib., Saussurea orgaadayi Khanm. & Krasnob., Saussurea involucrata (Kar. & Kir.) Sch.Bip., Saussurea bogedaensis Yu J.Wang & J.Chen)"
 ]
}

 The dataset includes 195 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013041-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pmn8en
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Acipenseriformes",
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 {
 "and" : [
 "Country is China",
 "Country is Hong Kong",
 "Country is Chinese Taipei",
 "Country is Macao"
 ]
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013042-240906103802322/datasets/export for details.
DOI: 10.5281/zenodo.13752800
title: QCA-2024-SCC-FJ03428 R&D data

description: Project Code: QCA-2024-SCC-FJ03428.This project is classified as CONFIDENTIAL. All information, data, and results associated with this project are strictly restricted to authorized personnel only. Any dissemination, distribution, or copying of the project details is strictly prohibited without prior approval from the project lead and the university's Office of Research Compliance.
DOI: 10.5281/zenodo.13752801
title: QCA-2024-SCC-FJ03428 R&D data

description: Project Code: QCA-2024-SCC-FJ03428.This project is classified as CONFIDENTIAL. All information, data, and results associated with this project are strictly restricted to authorized personnel only. Any dissemination, distribution, or copying of the project details is strictly prohibited without prior approval from the project lead and the university's Office of Research Compliance.
DOI: 10.17909/61c6-ah42
title: SY Cha observations used for 2nd JWST paper
DOI: 10.5519/qd.yuclndmi
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (154 records)
DOI: 10.15468/dl.hvfapq
title: Occurrence Download

description: A dataset containing 214726 species occurrences available in GBIF matching the query:
{
 "and" : [
 "BasisOfRecord is one of (Observation, Human Observation, Material sample, Material citation, Specimen, Occurrence evidence)",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "OccurrenceStatus is Present",
 "TaxonKey is Zygophyllaceae"
 ]
}

 The dataset includes 214726 records from 941 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013033-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.a9665j
title: Occurrence Download

description: A dataset containing 344 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Allium pruinatum Link ex Spreng."
 ]
}

 The dataset includes 344 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013043-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.zdpasg
title: Occurrence Download

description: A dataset containing 0 records in GBIF matching the query:
SELECT PRINTF('%04d-%02d', "year", "month") AS yearMonth, decimalLatitude AS lat, decimalLongitude AS lon, family, familyKey, genus, genusKey, species, speciesKey, iucnRedListCategory, basisOfRecord FROM occurrence WHERE iucnRedListCategory IN ('NT','VU','EN','CR','EW','EX','LC') AND occurrenceStatus = 'PRESENT' AND countryCode = '{{country}}' AND "year" &gt;= 1980 AND classKey = 359 AND hasCoordinate = TRUE AND (coordinateUncertaintyInMeters &lt;= 1000 OR coordinateUncertaintyInMeters IS NULL) AND speciesKey IS NOT NULL AND NOT ARRAY_CONTAINS(issue, 'ZERO_COORDINATE') AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_OUT_OF_RANGE') AND NOT ARRAY_CONTAINS(issue, 'COORDINATE_INVALID') AND NOT ARRAY_CONTAINS(issue, 'COUNTRY_COORDINATE_MISMATCH') AND "month" IS NOT NULL AND basisOfRecord IN ('HUMAN_OBSERVATION','MACHINE_OBSERVATION','MATERIAL_CITATION','OBSERVATION','OCCURRENCE') GROUP BY yearMonth, lat, lon, familyKey, family, genusKey, genus, speciesKey, species, iucnRedListCategory, basisOfRecord

 The dataset's 0 records were derived from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013023-240906103802322/datasets/export for details.
DOI: 10.4121/4567b5a9-f869-4cc5-af08-39f02feb5bed
title: I.AM. Archive containing experiments of a UR10 with suction gripper holding a Variable Inertia Object for suction cup stiffness identification

description: I.AM. dataset as part of the Impact-Aware Robotics Database. This dataset contains recordings of experiments with a robotic arm (UR10), holding a Variable Inertia Object with different inertias via a suction cup under vacuum. The purpose of these experiments is to identify the model parameters of a newly developed 6D suction cup model and validate this model under different circumstances. The involved contact is between the robot end-effector and the object.
DOI: 10.4121/4567b5a9-f869-4cc5-af08-39f02feb5bed.v1
title: I.AM. Archive containing experiments of a UR10 with suction gripper holding a Variable Inertia Object for suction cup stiffness identification

description: I.AM. dataset as part of the Impact-Aware Robotics Database. This dataset contains recordings of experiments with a robotic arm (UR10), holding a Variable Inertia Object with different inertias via a suction cup under vacuum. The purpose of these experiments is to identify the model parameters of a newly developed 6D suction cup model and validate this model under different circumstances. The involved contact is between the robot end-effector and the object.
DOI: 10.15468/dl.6hj4v9
title: Occurrence Download

description: A dataset containing 113 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Acipenseriformes",
 {
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Fossil, Living Specimen)"
 ]
 }
 }
 ]
 },
 {
 "or" : [
 "Country is China",
 "Country is Hong Kong",
 "Country is Chinese Taipei",
 "Country is Macao"
 ]
 }
 ]
}

 The dataset includes 113 records from 12 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013044-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5519/qd.tcocbboi
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (64 records)
DOI: 10.15468/dl.fk9ktx
title: Occurrence Download

description: A dataset containing 237 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Centaurea exarata Boiss. ex Coss."
 ]
}

 The dataset includes 237 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013045-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.5519/qd.34gefbio
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (285 records)
DOI: 10.5519/qd.cik9ztqd
title: Query on the Natural History Museum Data Portal (data.nhm.ac.uk) (13 records)
DOI: 10.5281/zenodo.10457932
title: TEI-XML-Datenset der Tagebücher, Briefe, Dokumente, Forschungsbeiträge, Chronologieeinträge und Register der edition humboldt digital

description: Das Datenset enthält alle edierten Texte (Tagebücher, Briefe und weitere Dokumente) sowie Paratexte (Forschungsbeiträge, Einträge der Chronologie zu Alexander von Humboldts Leben, Register und Glossar) der Version 8 der edition humboldt digital, die am 11. Mai 2022 erschienen ist.
DOI: 10.5281/zenodo.13752752
title: TEI-XML-Datenset der Tagebücher, Briefe, Dokumente, Forschungsbeiträge, Chronologieeinträge und Register der edition humboldt digital

description: Das Datenset enthält alle edierten Texte (Tagebücher, Briefe und weitere Dokumente) sowie Paratexte (Forschungsbeiträge, Einträge der Chronologie zu Alexander von Humboldts Leben, Register und Glossar) der Version 9 der edition humboldt digital, die am 4. Juli 2023 erschienen ist.
DOI: 10.5281/zenodo.13752841
title: TEI-XML-Datenset der Tagebücher, Briefe, Dokumente, Forschungsbeiträge, Chronologieeinträge und Register der edition humboldt digital

description: Das Datenset enthält alle edierten Texte (Tagebücher, Briefe und weitere Dokumente) sowie Paratexte (Forschungsbeiträge, Einträge der Chronologie zu Alexander von Humboldts Leben, Register und Glossar) der Version 10 der edition humboldt digital, die am 2. Juli 2024 erschienen ist.

Die Editionsrichtlinien stehen auf edition-humboldt.de zur Vefügung. Das Datenmodell ist in drei verschiedene ODDs aufgeteilt (für edierte Texte, Registereinträge und Forschungsbeiträge). Dem Datenset liegen die drei RNG-Schemata bei, die ODD-Ursprungsdateien sind im GitHub-Repository ediarum.AVHR.data-model zu finden. Beachten Sie bitte, dass es für das Pflanzenregister derzeit noch kein Schema gibt, da dieses aus dem Tagging automatisch erstellt wird.

Weitere Hinweise zur digitalen Methodik finden sich in Dumont 2024 und zum Editionsvorhaben im Allgemeinen in Kraft/Dumont 2020.

Dieses Datenset ist auch auf GitHub zugänglich.
DOI: 10.15468/dl.kpyysg
title: Occurrence Download

description: A dataset containing 63517 species occurrences available in GBIF matching the query:
{
 "GadmGid" : [
 "is UKR.6_1"
 ]
}

 The dataset includes 63517 records from 178 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0013046-240906103802322/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.4121/a0243e74-0f53-41f4-8b93-45067d1f37f3
title: I.AM. Archive containing experiments of a UR10 with vacuum gripper flipping and stacking boxes in a container for sequence 3

description: I.AM. dataset as part of the Impact-Aware Robotics Database. This dataset contains recordings of experiments with a robotic arm (UR10) that is manipulating various objects that arrive at a conveyor belt and places them into a container. This is also known as the Bin-Packing-Problem. The purpose of these experiments is to validate the modeling framework that includes the robot, gripper with suction cup, and the interaction with the objects and the surroundings. Therefore, these experiment support the validation of simulations run in a simulator based on these models, for which we use Algoryx Dynamics. In total, five different sequences are executed with different boxes arriving at the conveyor and this dataset contains one of these sequences. The whole experiment is executed 3 times. Besides these experiments, the dataset contains a calibration experiment used to calibrate the Force/Torque sensor placed between the robot and the gripper. This datasets concerns Sequence 3.
DOI: 10.4121/a0243e74-0f53-41f4-8b93-45067d1f37f3.v1
title: I.AM. Archive containing experiments of a UR10 with vacuum gripper flipping and stacking boxes in a container for sequence 3

description: I.AM. dataset as part of the Impact-Aware Robotics Database. This dataset contains recordings of experiments with a robotic arm (UR10) that is manipulating various objects that arrive at a conveyor belt and places them into a container. This is also known as the Bin-Packing-Problem. The purpose of these experiments is to validate the modeling framework that includes the robot, gripper with suction cup, and the interaction with the objects and the surroundings. Therefore, these experiment support the validation of simulations run in a simulator based on these models, for which we use Algoryx Dynamics. In total, five different sequences are executed with different boxes arriving at the conveyor and this dataset contains one of these sequences. The whole experiment is executed 3 times. Besides these experiments, the dataset contains a calibration experiment used to calibrate the Force/Torque sensor placed between the robot and the gripper. This datasets concerns Sequence 3.
DOI: 10.6084/m9.figshare.27003118
title: Dryneedling or magnesium injections for Myofascial Pain Syndrom

description: This is a randomized controlled study comparing DryNeedling to magnesium injections in patients with myofascial pain syndrome. <b>Objective:</b> This study aimed to compare the effectiveness of dry needling (DN) versus magnesium (Mg) infiltration in treating myofascial pain syndrome (MPS) with respect to pain reduction, quality of life (QOL), and symptoms of anxiety and depression.<b>Methods:</b> A randomized controlled trial (RCT) was conducted involving 45 patients with MPS. Participants were randomly assigned to Group A (dry needling) or Group B (magnesium infiltration). Both interventions were applied, and outcomes were assessed at baseline, one month, three months, and six months. Primary outcomes included pain intensity measured by the Visual Analog Scale (VAS), while secondary outcomes encompassed mental and physical health assessed via the SF-12 Mental and Physical Health Scales, and depression and anxiety levels measured by the Hospital Anxiety and Depression Scale (HAD).<b>Results:</b> Both interventions led to significant improvements in pain intensity, mental health, physical health, and reductions in depression and anxiety at one and three months. However, by six months, the differences in outcomes between the two groups were no longer significant. The mean changes in VAS scores, SF-12 scores, and HAD scores showed no significant differences between Group A and Group B at any follow-up time point.<b>Conclusion:</b> Dry needling and magnesium infiltration were both effective in the short to medium term for reducing pain and improving quality of life in patients with MPS. Despite significant improvements within each group, no superior effectiveness was observed between the two treatments. Both methods offer viable options for managing MPS, though additional long-term studies are needed to determine their sustained effectiveness and optimal use in clinical practice.<br>
DOI: 10.6084/m9.figshare.27003118.v1
title: Dryneedling or magnesium injections for Myofascial Pain Syndrom

description: This is a randomized controlled study comparing DryNeedling to magnesium injections in patients with myofascial pain syndrome. <b>Objective:</b> This study aimed to compare the effectiveness of dry needling (DN) versus magnesium (Mg) infiltration in treating myofascial pain syndrome (MPS) with respect to pain reduction, quality of life (QOL), and symptoms of anxiety and depression.<b>Methods:</b> A randomized controlled trial (RCT) was conducted involving 45 patients with MPS. Participants were randomly assigned to Group A (dry needling) or Group B (magnesium infiltration). Both interventions were applied, and outcomes were assessed at baseline, one month, three months, and six months. Primary outcomes included pain intensity measured by the Visual Analog Scale (VAS), while secondary outcomes encompassed mental and physical health assessed via the SF-12 Mental and Physical Health Scales, and depression and anxiety levels measured by the Hospital Anxiety and Depression Scale (HAD).<b>Results:</b> Both interventions led to significant improvements in pain intensity, mental health, physical health, and reductions in depression and anxiety at one and three months. However, by six months, the differences in outcomes between the two groups were no longer significant. The mean changes in VAS scores, SF-12 scores, and HAD scores showed no significant differences between Group A and Group B at any follow-up time point.<b>Conclusion:</b> Dry needling and magnesium infiltration were both effective in the short to medium term for reducing pain and improving quality of life in patients with MPS. Despite significant improvements within each group, no superior effectiveness was observed between the two treatments. Both methods offer viable options for managing MPS, though additional long-term studies are needed to determine their sustained effectiveness and optimal use in clinical practice.<br>
DOI: 10.6084/m9.figshare.27003160
title: HCV NS5B Sequences for Phylogenetic and Bayesian Evolutionary Analysis from Huazhou County

description: This file contains HCV NS5B sequences formatted for use in the BEAST software package for Bayesian evolutionary analysis. The sequences were used to estimate the substitution rate, the time to the most recent common ancestor (TMRCA), and other evolutionary parameters.
DOI: 10.6084/m9.figshare.27003160.v1
title: HCV NS5B Sequences for Phylogenetic and Bayesian Evolutionary Analysis from Huazhou County

description: This file contains HCV NS5B sequences formatted for use in the BEAST software package for Bayesian evolutionary analysis. The sequences were used to estimate the substitution rate, the time to the most recent common ancestor (TMRCA), and other evolutionary parameters.
DOI: 10.5281/zenodo.13744779
title: QCA-2024-SCC-001 R&D data

description: Project Code: QCA-2024-SCC-001

This project is classified as CONFIDENTIAL. All information, data, and results associated with this project are strictly restricted to authorized personnel only. Any dissemination, distribution, or copying of the project details is strictly prohibited without prior approval from the project lead and the university's Office of Research Compliance.
DOI: 10.5281/zenodo.13744780
title: QCA-2024-SCC-001 R&D data

description: Project Code: QCA-2024-SCC-001

This project is classified as CONFIDENTIAL. All information, data, and results associated with this project are strictly restricted to authorized personnel only. Any dissemination, distribution, or copying of the project details is strictly prohibited without prior approval from the project lead and the university's Office of Research Compliance.