cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24261385.v5
title: Lili-Mip trajectories and results.zip

description: The unique viviparous Pacific Beetle cockroaches provide nutrition to their<br>embryo by secreting milk proteins Lili-Mip, which is a lipid-binding glycoprotein that crys-<br>tallizes in vivo. The resolved in vivo crystal structure of variably glycosylated Lili-Mip<br>shows a classical Lipocalin fold with an eight-stranded antiparallel beta-barrel enclosing a<br>fatty acid. The availability of physiologically unaltered glycoprotein structure makes Lili-<br>Mip a very attractive model system to investigate the role of glycans on protein structure,<br>dynamics, and function. Towards that end, we have employed all-atom molecular dynamics<br>simulations on various glycosylated stages of a bound and free Lili-Mip protein and charac-<br>terized the impact of glycans and the bound lipid on the dynamics of this glycoconjugate.<br>Our work provides important molecular-level mechanistic insights into the role of glycans in<br>the nutrient storage function of the Lili-Mip protein. Our analyses show that the glycans<br>locally stabilize spatially proximal residues and regulate the low amplitude opening motions<br>of the residues at the entrance of the binding pocket. Glycans, which are located at the<br>portal end of the barrel, also restrict the distal barrel depth and allosterically modulate<br>the lipid dynamics in the barrel. A simple but effective distance-based network analysis<br>of the protein also reveals the role of glycans in the subtle rewiring of residues crucial for<br>determining the barrel depth and lipid orientation
DOI: 10.5281/zenodo.10065785
title: Supplementary material to `Accelerating Lagrangian transport simulations on graphics processing units: performance optimizations of MPTRAC v2.6'

description: This repository contains the supplementary material to the following paper: Hoffmann, L., Haghighi Mood, K., Herten, A., Hrywniak, M., Kraus, J., Clemens, J., and Liu, M., Accelerating Lagrangian transport simulations on graphics processing units: performance optimizations of MPTRAC v2.6, Geoscientific Model Development, submitted, 2023.
DOI: 10.5281/zenodo.10065784
title: Supplementary material to `Accelerating Lagrangian transport simulations on graphics processing units: performance optimizations of MPTRAC v2.6'

description: This repository contains the supplementary material to the following paper: Hoffmann, L., Haghighi Mood, K., Herten, A., Hrywniak, M., Kraus, J., Clemens, J., and Liu, M., Accelerating Lagrangian transport simulations on graphics processing units: performance optimizations of MPTRAC v2.6, Geoscientific Model Development, submitted, 2023.
DOI: 10.6084/m9.figshare.24473116
title: Particle Size Analyzer (PSA) of Tithonia diversifolia

description: This image contain the particle analzyer of Tithonia diversifolia
DOI: 10.6084/m9.figshare.24473116.v1
title: Particle Size Analyzer (PSA) of Tithonia diversifolia

description: This image contain the particle analzyer of Tithonia diversifolia
DOI: 10.5281/zenodo.10065838
title: Cropped News Article from University of Potsdam News Site

description: This data was cropped from the University of Potsdam news website. The annotated labels are made by the writers of the articles.
DOI: 10.5281/zenodo.10065837
title: Cropped News Article from University of Potsdam News Site

description: This data was cropped from the University of Potsdam news website. The annotated labels are made by the writers of the articles.
DOI: 10.6084/m9.figshare.24420757
title: Supplementary Material for: Rare case of advanced gastric cancer complicated with fibrinogen storage disease treated with chemotherapy plus immune checkpoint inhibitor: A case report

description: The administration of chemotherapy to cancer patients with organ dysfunction raises concerns regarding its safety. The safety profile of patients with organ dysfunction due to rare diseases treated with chemotherapy plus immune checkpoint inhibitor is limited. Fibrinogen storage disease (FSD) is a rare disease that causes liver dysfunction by endoplasmic reticulum stress response due to abnormal accumulation of fibrinogen in the endoplasmic reticulum of hepatocytes. Although chemotherapy plus nivolumab is recommended as a standard first-line treatment for patients with advanced gastric cancer (AGC), its safety profile for patients with FSD is rarely available. In this study, an 80-year-old male with gastric cancer with positive lavage cytology was scheduled to receive palliative chemotherapy. This case had liver dysfunction of unknown cause, and a liver biopsy was performed. Histopathological findings revealed a diagnosis of Type II/III fibrinogen inclusion based on morphology and immunohistochemistry. Liver function was recovered by administering ursodeoxycholic acid (UDCA). Therefore, the combination chemotherapy of S-1, oxaliplatin, with nivolumab as palliative chemotherapy was initiated. The case responded well to chemotherapy and achieved conversion surgery without worsening of liver function. We report a case of advanced gastric cancer with fibrinogen inclusion complication where chemotherapy was safely administered with a good outcome. The combination therapy of cytotoxic drugs and immune checkpoint inhibitors may be safely and effectively administered to such patients.
DOI: 10.6084/m9.figshare.24420757.v1
title: Supplementary Material for: Rare case of advanced gastric cancer complicated with fibrinogen storage disease treated with chemotherapy plus immune checkpoint inhibitor: A case report

description: The administration of chemotherapy to cancer patients with organ dysfunction raises concerns regarding its safety. The safety profile of patients with organ dysfunction due to rare diseases treated with chemotherapy plus immune checkpoint inhibitor is limited. Fibrinogen storage disease (FSD) is a rare disease that causes liver dysfunction by endoplasmic reticulum stress response due to abnormal accumulation of fibrinogen in the endoplasmic reticulum of hepatocytes. Although chemotherapy plus nivolumab is recommended as a standard first-line treatment for patients with advanced gastric cancer (AGC), its safety profile for patients with FSD is rarely available. In this study, an 80-year-old male with gastric cancer with positive lavage cytology was scheduled to receive palliative chemotherapy. This case had liver dysfunction of unknown cause, and a liver biopsy was performed. Histopathological findings revealed a diagnosis of Type II/III fibrinogen inclusion based on morphology and immunohistochemistry. Liver function was recovered by administering ursodeoxycholic acid (UDCA). Therefore, the combination chemotherapy of S-1, oxaliplatin, with nivolumab as palliative chemotherapy was initiated. The case responded well to chemotherapy and achieved conversion surgery without worsening of liver function. We report a case of advanced gastric cancer with fibrinogen inclusion complication where chemotherapy was safely administered with a good outcome. The combination therapy of cytotoxic drugs and immune checkpoint inhibitors may be safely and effectively administered to such patients.
DOI: 10.6084/m9.figshare.24465973.v1
title: Supplementary Material for: Successful MRI-guided focused ultrasound thalamotomy after ipsilateral Gamma Knife radiosurgery for essential tremor: a case report with video

description: We report the case of a 67-year-old left-handed female patient with disabling medically-refractory essential tremor who underwent successful right-sided Magnetic Resonance-guided focused ultrasound (MRgFUS) of the ventral intermediate (VIM) nucleus after ipsilateral Gamma Knife radiosurgery (GKRS) thalamotomy performed three years earlier. The GKRS had a partial effect on her postural tremor without side effects, but there was no reduction of her kinetic tremor, nor improvement in her quality of life (QoL). The patient subsequently underwent a MRgFUS thalamotomy, which induced an immediate and marked reduction in both the postural and kinetic tremor components, with minor complications (left upper lip hypoesthesia, dysmetria in her left hand, and slight gait ataxia). The MRgFUS-induced lesion was centered more medially than the GKRS-induced lesion and extended more posteriorly and inferiorly. The MRgFUS-induced lesion interrupted remaining fibres of the dentatorubrothalamic tract (DRTT). The functional improvement one-year post-MRgFUS was significant due to a marked reduction of the patient’s kinetic tremor. The QoL score (QUEST) improved by 88% and her CRST left hand score by 62%. The side effects persisted but were minor, with no impact on her QoL. The explanation for the superior efficacy of MRgFUS compared to GKRS in our patient could be due to either a poor response to the GKRS or to a better localisation of the MRgFUS lesion with a more extensive interruption of DRTT fibers. In conclusion, MRgFUS can be a valuable therapeutic option after unsatisfactory GKRS especially because MRgFUS has immediate clinical effectiveness, allowing intra-procedural test lesions and possible readjustment of the target if necessary.
DOI: 10.6084/m9.figshare.24465973
title: Supplementary Material for: Successful MRI-guided focused ultrasound thalamotomy after ipsilateral Gamma Knife radiosurgery for essential tremor: a case report with video

description: We report the case of a 67-year-old left-handed female patient with disabling medically-refractory essential tremor who underwent successful right-sided Magnetic Resonance-guided focused ultrasound (MRgFUS) of the ventral intermediate (VIM) nucleus after ipsilateral Gamma Knife radiosurgery (GKRS) thalamotomy performed three years earlier. The GKRS had a partial effect on her postural tremor without side effects, but there was no reduction of her kinetic tremor, nor improvement in her quality of life (QoL). The patient subsequently underwent a MRgFUS thalamotomy, which induced an immediate and marked reduction in both the postural and kinetic tremor components, with minor complications (left upper lip hypoesthesia, dysmetria in her left hand, and slight gait ataxia). The MRgFUS-induced lesion was centered more medially than the GKRS-induced lesion and extended more posteriorly and inferiorly. The MRgFUS-induced lesion interrupted remaining fibres of the dentatorubrothalamic tract (DRTT). The functional improvement one-year post-MRgFUS was significant due to a marked reduction of the patient’s kinetic tremor. The QoL score (QUEST) improved by 88% and her CRST left hand score by 62%. The side effects persisted but were minor, with no impact on her QoL. The explanation for the superior efficacy of MRgFUS compared to GKRS in our patient could be due to either a poor response to the GKRS or to a better localisation of the MRgFUS lesion with a more extensive interruption of DRTT fibers. In conclusion, MRgFUS can be a valuable therapeutic option after unsatisfactory GKRS especially because MRgFUS has immediate clinical effectiveness, allowing intra-procedural test lesions and possible readjustment of the target if necessary.
DOI: 10.5281/zenodo.10065821
title: Using Artificial Intelligence in Research: Academic Staff of Ukrainian HEIs

description: The survey was conducted by the researchers of the Institute of Higher Education of NAES of Ukraine (https://ihed.org.ua/). Empirical data was collected from March 21 to April 3, 2023. The Register of Education Institutions of the Unified State Electronic Database on Education (https://registry.edbo.gov.ua/) was the source for the targeted sample.
DOI: 10.5281/zenodo.10065933
title: Data from the paper "RFI flagging in solar and space weather low frequency radio observations' by Zhang et al. 2023

description: Data from the paper "RFI flagging in solar and space weather low frequency radio observations' by Zhang et al. 2023
DOI: 10.5281/zenodo.10065932
title: Data from the paper "RFI flagging in solar and space weather low frequency radio observations' by Zhang et al. 2023

description: Data from the paper "RFI flagging in solar and space weather low frequency radio observations' by Zhang et al. 2023
DOI: 10.6084/m9.figshare.24486385
title: Household saving and its determinants dataset in selected CEE countries (seasonally and calendar adjusted data)

description: This database can be used for econometric models that examine the determinants of household savings.
DOI: 10.6084/m9.figshare.24486325.v1
title: Data.xlsx

description: The data for this study originated from the online forum “Underperforming Arguments” within Douban (https://www.douban.com/group/634971/), a Chinese social network and cultural community. Data scraping was then performed using the Google Chrome extension Web Scraper, resulting in a total of 819 posts that formed the initial dataset. The rigorous preprocessing resulted in a final dataset of 606 posts that met the specified criteria.
DOI: 10.23729/a978d68e-a57e-4ad4-9916-1d3fbbd52fd4
title: Carbonate Breccia preview

description: Two samples from a carbonate-rich breccia filling a shear zone encountered when drilling in the vicinity of Kiruna deposit. Samples were scanned to see if there were any shear indications to see if the fault had moved after the breccia was emplaced and if so, in what direction. The breccia turned out to be unfoliated. Preview of PAS-dataset https://doi.org/10.23729/3da0707f-1fee-4737-8135-6ee4ecaf1cee
DOI: 10.15131/shef.data.24460351.v1
title: Truss bridge under static loading: a dataset containing the reaction of a laboratory-scale truss bridge to static loading

description: This dataset is designed to identify the loads transmitted through the struts of a laboratory-scale truss bridge when the bridge is loaded. Various loading scenarios are included, and the effect of damage to the bridge is also tested.
DOI: 10.15131/shef.data.24460351
title: Truss bridge under static loading: a dataset containing the reaction of a laboratory-scale truss bridge to static loading

description: This dataset is designed to identify the loads transmitted through the struts of a laboratory-scale truss bridge when the bridge is loaded. Various loading scenarios are included, and the effect of damage to the bridge is also tested.
DOI: 10.5281/zenodo.10066003
title: Mapa de los pueblos y despoblados que tienen final en -ain

description: Mapa de los pueblos y despoblados que tienen final en -ain.
DOI: 10.5281/zenodo.6637771
title: Mapa de los pueblos y despoblados que tienen final en -ain

description: Mapa de los pueblos y despoblados que tienen final en -ain.
DOI: 10.5281/zenodo.6637772
title: Mapa de los pueblos y despoblados que tienen final en -ain

description: Mapa de los pueblos y despoblados que tienen final en <em>-ain</em>.
DOI: 10.18715/ipgp.2023.ldbm60lm
title: Experimental data from analog models investigating upper-plate shortening and Andean-type mountain-building in the context of mantle-driven oceanic subduction

description: This dataset includes videos and photographs depicting the evolution in top and lateral views of 5 analogue experiments of subduction to better understand upper-plate shortening and Andean-type mountain-building in the context of mantle-driven oceanic subduction. For details on the experimental set-up, monitoring techniques and interpretation of the results, please refer to Habel et al. (2023) to which these data are supplementary material. Reference: T. Habel, A. Replumaz, B. Guillaume, M. Simoes, T. Geffroy, J.-J. Kermarrec and R. Lacassin (2023): Upper-plate shortening and mountain-building in the context of mantle-driven oceanic subduction., Tektonika, 1 (2), doi:10.55575/tektonika2023.1.2.39.
DOI: 10.5281/zenodo.10066013
title: Gameful experience and student engagement: A Comparative Study of Role-Playing and Puzzle Games in Higher Education
DOI: 10.5281/zenodo.10066012
title: Gameful experience and student engagement: A Comparative Study of Role-Playing and Puzzle Games in Higher Education
DOI: 10.6084/m9.figshare.24486418
title: Strong crustal heterogeneity of the Xianshuihe-Anninghe-Zemuhe fault system and its vicinity revealed by velocity and azimuthal anisotropy structures

description: The Xianshuihe-Anninghe-Zemuhe (XAZ) fault system acts as the western boundary of the Chuan-Dian Block, and it separates the Chuan-Dian Block from the Songpan-Ganzi Block (SGB) and the Yangtze Block. Due to the SE-ward expansion of the Tibetan Plateau, strong crustal deformation has occurred in the XAZ fault system and its vicinity. Although many studies on the crustal deformation have been conducted in the past twenty years, some key issues remain poorly resolved. To further investigate the crustal deformation, we perform P-wave anisotropy tomography using an eikonal equation-based tomography method, and obtain high resolution 3D P-wave velocity and azimuthal anisotropy images beneath the XAZ fault system and its vicinity. Our tomographic results show two separate strong low-velocity bodies in the mid-lower crust of the XAZ fault system. In addition, our results do not present a consistent anisotropy pattern with fast velocity directions parallel to the strike of the XAZ fault system. Based on these features, we conclude that mid-lower crustal flow, which is employed to explain the expansion of the Tibetan Plateau, is not occurring along the XAZ fault system. Furthermore, our tomographic results display a high-velocity body in the upper crust below the SGB, and the high-velocity body connects with the high-velocity anomaly beneath the Sichuan Basin (SCB). According to these features, we suggest that the Yangtze crystalline basement penetrates into the eastern Tibetan Plateau across the Longmenshan fault.
DOI: 10.6084/m9.figshare.24486415
title: Representation of Women as Commissioners of the Aceh Province Electiob Supervisory Body

description: This data is the result of research processed by the author
DOI: 10.6084/m9.figshare.24486415.v1
title: Representation of Women as Commissioners of the Aceh Province Electiob Supervisory Body

description: This data is the result of research processed by the author
DOI: 10.6084/m9.figshare.24468277
title: RMDsignatures_exposures_k=13_nFact13_n=4221.csv

description: Regional mutation density (RMD) signatures obtained after appling NMF into a matrix of mutation density across 1Mb windows along the genome for 4221 tumor samples. The values provided (NMF exposures) represent the number of mutations that comes from each specific signature in each sample. The exposures are not normalized.
DOI: 10.6084/m9.figshare.24468277.v2
title: RMDsignatures_exposures_k=13_nFact13_n=4221.csv

description: Regional mutation density (RMD) signatures obtained after appling NMF into a matrix of mutation density across 1Mb windows along the genome for 4221 tumor samples. The values provided (NMF exposures) represent the number of mutations that comes from each specific signature in each sample. The exposures are not normalized.
DOI: 10.6084/m9.figshare.24468277.v1
title: RMDsignatures_exposures_k=13_nFact13_n=4221.csv

description: Regional mutation density (RMD) signatures obtained after appling NMF into a matrix of mutation density across 1Mb windows along the genome for 4221 tumor samples. The values provided (NMF exposures) represent the number of mutations that comes from each specific signature in each sample. The exposures are not normalized.
DOI: 10.6084/m9.figshare.24476962
title: epi_data.csv

description: Table to facilitate describing the csv format. NOT REAL DATA.
DOI: 10.6084/m9.figshare.24476962.v1
title: epi_data.csv

description: Table to facilitate describing the csv format. NOT REAL DATA.
DOI: 10.6084/m9.figshare.24486481
title: PCA_chrom_RT.zip

description: To quantify the systematic variation of epigenomic features at the domain level, we performed PCAs on the megabase-window signal of the H3K9me3 and H3K27me3 heterochromatin marks, RT, DHS, and Hi-C compartments. Here, we provide the PC rotation matrix (window weigths across the 1 Mb windows) and the PC matrix (exposures across the different samples) for each of these epigenomic features.<br>
DOI: 10.6084/m9.figshare.24486481.v1
title: PCA_chrom_RT.zip

description: To quantify the systematic variation of epigenomic features at the domain level, we performed PCAs on the megabase-window signal of the H3K9me3 and H3K27me3 heterochromatin marks, RT, DHS, and Hi-C compartments. Here, we provide the PC rotation matrix (window weigths across the 1 Mb windows) and the PC matrix (exposures across the different samples) for each of these epigenomic features.<br>
DOI: 10.6084/m9.figshare.24466228
title: Supplementary Material for: Retroperitoneal Hematoma as an Atypical Presentation of Choriocarcinoma: Case Report

description: A 38-year-old female with an etonogestrel implant in place and history of previous ectopic pregnancy presented with acute abdominal pain and vaginal bleeding. She was found to have a beta-Hcg of &gt;12,000 mIU/mL and free fluid noted on a focused assessment with sonography in trauma (FAST) exam. She underwent an emergent diagnostic laparoscopy due to the suspicion of a ruptured ectopic pregnancy. Findings at the time of surgery included normal appearing uterus and left fallopian tube, a surgically absent right fallopian tube and large volume hemoperitoneum with a rapidly expanding left retroperitoneal hematoma. A post-operative computed tomography (CT) angiogram suggested active bleeding from a pseudoaneurysm of the left renal artery which was successfully embolized by interventional radiology (IR). Biopsy confirmed gestational trophoblastic neoplasia (GTN) after metastases to the brain. In this report, we describe the details of this case of GTN with an atypical presentation.
DOI: 10.6084/m9.figshare.24467053
title: Supplementary Material for: Exceptional response to pembrolizumab in a mismatch-repair deficient aggressive prostate cancer with somatic EPCAM, MSH2 and MSH6 co-deletion: a case report

description: Mismatch repair deficient (dMMR) prostate cancer (PCa) is a rare (1-5%) but highly actionable molecular subgroup of PCa, vulnerable to immune checkpoint inhibitors. Our case of sporadic dMMR PCa due to large monoallelic co-deletion of EPCAM, MSH2 and MSH6, features a clinically aggressive disease presentation and a major response to pembrolizumab. We report a 65-year-old patient with primary metastatic PCa, Gleason score 5+5=10, with penile and lymph node metastases at diagnosis. Patient showed rapid progression on first-line ADT and enzalutamide. Tumor next-generation sequencing (NGS) revealed microsatellite instability and a tumor mutational burden of 40.8 mutations/megabase. Immunohistochemistry showed co-loss of MSH2 and MSH6. Review of NGS row data confirmed large monoallelic deletion in chromosome 2p, including EPCAM, MSH2 and MSH6. No germline alterations in mismatch repair genes were detected. Patient showed excellent response to pembrolizumab, which is still ongoing. We conclude that early molecular tumor profiling is essential to enable personalized management of advanced prostate cancer, especially in patients with aggressive or atypical disease course.