cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.17882/105485
title: MOBILIS surveys : Field observations in Lebris Bay - Houailou (New Caledonia - North Province)

description: Following a massive fish kill (January 2022), Lebris Bay located in Houailou on the east coast of New Caledonia has been instrumented over a period of 4 months (from December 2022 to April 2023) in order to characterize its hydrodynamics functioning. Six sensors have been moored to measure and quantify water circulation and exchanges between bay, lagoon and ocean (current, temperature, salinity and pressure).
DOI: 10.6084/m9.figshare.24564672
title: Cost-effectiveness of high-dose quadrivalent influenza vaccine versus standard-dose quadrivalent influenza vaccine for older people in a country with high influenza vaccination rate

description: The highdose quadrivalent influenza vaccine (QIVHD) has shown improved protection against influenza and its complications in older adults. We aimed to evaluate the costeffectiveness of QIVHD compared with QIVSD among Korean adults aged ≥ 65 years in reducing influenzarelated disease burden. We evaluated the 2016/2017 and 2017/2018 seasons and their average values using a static decision tree model. The difference in efficacy between standard-dose (SD) and high-dose (HD) was calculated based on the results of a clinical trial comparing Fluzone® High-Dose Vaccine and Fluzone® Vaccine in older adults. Incremental cost-effectiveness ratios (ICERs) were assessed from the healthcare system perspective. A discount rate of 4.5% was applied to life-year-gained (LYG) values and utilities. We performed deterministic and probabilistic sensitivity analyses to account for both epidemiological and economic sources of uncertainty. In the analysis of the 2017/2018 season, the QIV-HD strategy generated an excess of 0.00182 life-years (Lys)/person and 0.003953 quality-adjusted life-years (QALYs)/person compared with QIV-SD. The ICER was 6,467.56 United States Dollars (USD)/QALY. In the analysis from the 2016/2017 season, QIV-HD caused a surplus of 0.00117 Lys/person and 0.003272 QALYs/person compared with QIV-SD. ICER was 7,902.46 USD /QALY. From the average data of the 2016/2017 and 2017/2018 seasons, an excess of 0.00147 Lys/person and 0.003561 QALYs/person were generated using QIV-HD compared with QIV-SD, while the ICER was 7,190.44 USD /QALY. From the healthcare system perspective, QIV-HD was a more cost-effective vaccination option in reducing influenza-related disease burden and healthcare costs in Koreans aged ≥ 65 years compared with QIV-SD.
DOI: 10.6084/m9.figshare.24564672.v2
title: Cost-effectiveness of high-dose quadrivalent influenza vaccine versus standard-dose quadrivalent influenza vaccine for older people in a country with high influenza vaccination rate

description: The highdose quadrivalent influenza vaccine (QIVHD) has shown improved protection against influenza and its complications in older adults. We aimed to evaluate the costeffectiveness of QIVHD compared with QIVSD among Korean adults aged ≥ 65 years in reducing influenzarelated disease burden. We evaluated the 2016/2017 and 2017/2018 seasons and their average values using a static decision tree model. The difference in efficacy between standard-dose (SD) and high-dose (HD) was calculated based on the results of a clinical trial comparing Fluzone® High-Dose Vaccine and Fluzone® Vaccine in older adults. Incremental cost-effectiveness ratios (ICERs) were assessed from the healthcare system perspective. A discount rate of 4.5% was applied to life-year-gained (LYG) values and utilities. We performed deterministic and probabilistic sensitivity analyses to account for both epidemiological and economic sources of uncertainty. In the analysis of the 2017/2018 season, the QIV-HD strategy generated an excess of 0.00182 life-years (Lys)/person and 0.003953 quality-adjusted life-years (QALYs)/person compared with QIV-SD. The ICER was 6,467.56 United States Dollars (USD)/QALY. In the analysis from the 2016/2017 season, QIV-HD caused a surplus of 0.00117 Lys/person and 0.003272 QALYs/person compared with QIV-SD. ICER was 7,902.46 USD /QALY. From the average data of the 2016/2017 and 2017/2018 seasons, an excess of 0.00147 Lys/person and 0.003561 QALYs/person were generated using QIV-HD compared with QIV-SD, while the ICER was 7,190.44 USD /QALY. From the healthcare system perspective, QIV-HD was a more cost-effective vaccination option in reducing influenza-related disease burden and healthcare costs in Koreans aged ≥ 65 years compared with QIV-SD.
DOI: 10.6084/m9.figshare.24864635
title: Mothers’ intention to vaccinate their daughters against human papillomavirus in NorthWest Ethiopia, using the theory of planned behavior

description: Human papillomavirus (HPV) is the second most common cause of cancer worldwide among females. HPV vaccination is highly protective against HPV infection and can reduce 56% of HPV infections. Therefore, the study aims to assess mothers’ intention to vaccinate their daughters aged 9–14 years old against human papillomavirus in Debre Tabor town, Northwest Ethiopia, using the theory of planned behavior. A community-based cross-sectional study design was employed using the theory of planned behavior from November 1 to 30, 2022, in Northwest Ethiopia. A total sample of 449 study participants was enrolled. The study participants were selected using a multi-stage random sampling technique. Data was collected using an interview-administered questionnaire. The data was entered into EPI data version 4.6 and then, exported to SPSS version 23 for analysis. Those variables with a p-value &lt;.05 with 95% CI were considered significant predictors. Mothers’ positive intention to vaccinate their daughters aged 9–14 years against HPV was 67.5%. Attitude, perceived behavioral control, and subjective norm were significant predictors with (AOR = 10.09, 95% CI = 6.23–16.32), (AOR = 4.12, 95% CI = 2.71–6.26), and (AOR = 16.397, 95% CI = 9.69–27.748), respectively. Only two-thirds of mothers have a positive intention to vaccinate their daughters against human papillomavirus. Attitude, perceived behavioral control, and subjective norm were predictors. Therefore, it is better to do community mobilization toward the advantage of HPV vaccination.
DOI: 10.6084/m9.figshare.24864635.v1
title: Mothers’ intention to vaccinate their daughters against human papillomavirus in NorthWest Ethiopia, using the theory of planned behavior

description: Human papillomavirus (HPV) is the second most common cause of cancer worldwide among females. HPV vaccination is highly protective against HPV infection and can reduce 56% of HPV infections. Therefore, the study aims to assess mothers’ intention to vaccinate their daughters aged 9–14 years old against human papillomavirus in Debre Tabor town, Northwest Ethiopia, using the theory of planned behavior. A community-based cross-sectional study design was employed using the theory of planned behavior from November 1 to 30, 2022, in Northwest Ethiopia. A total sample of 449 study participants was enrolled. The study participants were selected using a multi-stage random sampling technique. Data was collected using an interview-administered questionnaire. The data was entered into EPI data version 4.6 and then, exported to SPSS version 23 for analysis. Those variables with a p-value &lt;.05 with 95% CI were considered significant predictors. Mothers’ positive intention to vaccinate their daughters aged 9–14 years against HPV was 67.5%. Attitude, perceived behavioral control, and subjective norm were significant predictors with (AOR = 10.09, 95% CI = 6.23–16.32), (AOR = 4.12, 95% CI = 2.71–6.26), and (AOR = 16.397, 95% CI = 9.69–27.748), respectively. Only two-thirds of mothers have a positive intention to vaccinate their daughters against human papillomavirus. Attitude, perceived behavioral control, and subjective norm were predictors. Therefore, it is better to do community mobilization toward the advantage of HPV vaccination.
DOI: 10.17882/105883
title: Capelinhos edifice (Lucky Srike Hydrothermal Field, Mid Atlantic Ridge) 2023: 3D textured model and imagery

description: The Capelinhos hydrothermal vent site is a large edifice of 588 m² from its base. Located off axis, 1.5 km east of the central lava lake of the main Lucky Strike Hydrothermal Vent Field (mLSHVF), it is characterised by distinct geochemical and thermal conditions from the others mLSHVF edifices, with notably high iron concentrations compared to sites around the lava lake. The edifice has been surveyed with the remotely operated vehicle Victor6000 for inter-annual monitoring during the 2023 Momarsat cruise. Video transects were collected during dive 844-6 with a forward-looking camera and video sequences were used to build 3D models of the edifice using structure-from-motion techniques. A first dataset includes 2971 images extracted every 2 seconds from the videos.  The images are time-stamped and linked to a navigation file, which is generated by interpolating navigation data at the corresponding timestamps. A second dataset includes a 3D textured model of the site (obj format) together with the a kml file for georeferencing. The ROV navigation file (.txt) is provided separately.
Point :   37.28948183 (lat) -32.26413676 (long) -1663.487 (depth)
DOI: 10.6084/m9.figshare.24559246.v1
title: Association between sex hormones and anti-S/RBD antibody responses to COVID-19 vaccines in healthcare workers

description: Healthcare workers (HCWs) are the target population for vaccination against coronavirus disease (COVID-19) as they are at a high risk of exposure and transmission of pathogens to patients. Neutralizing antibodies developed after COVID-19 vaccination decline within few months of vaccination. Several factors, including age and sex, can affect the intensity, efficacy, and duration of immune response to vaccines. However, sex-specific analyses of humoral responses to COVID-19 vaccines are lacking. This study aimed to evaluate sex-based differences in anti-S/RBD (Receptor Binding Domain) responses at three different time points after the second dose of mRNA COVID-19 vaccine in HCWs in relation to age, and to investigate the role of sex hormones as potential markers of response. Anti-S/RBD levels after two doses of the mRNA vaccine were collected from 521 HCWs naïve to COVID-19, working at two Italian Clinical Centers. Multiple regression analysis was applied to evaluate the association between anti-S levels and sex, age, and plasma levels of sex hormones. Significantly higher anti-S/RBD response to the COVID-19 vaccination was found in female HCWs, and a significant and more abrupt decline in response with time was observed in women than that in men. A novel, positive association of testosterone plasma levels and higher anti-S levels in male HCWs was found, suggesting its potential role as sex specific marker in males. In conclusion, understanding the sex-based differences in humoral immune responses to vaccines may potentially improve vaccination strategies and optimize surveillance programs for HCWs.
DOI: 10.17882/105884
title: Sintra edifice (Lucky Srike Hydrothermal Field, Mid Atlantic Ridge) 2023: 3D textured model and imagery

description: The Sintra hydrothermal vent site reconstructed in this dataset is 311.82 m². It is located in the North east of the main Lucky Strike Hydrothermal Vent Field (LSHF). The edifice has been surveyed with the remotely operated vehicle Victor6000 for inter-annual monitoring during the 2023 Momarsat cruise. Video transects were collected during dive 844-6 with a forward-looking camera and video sequences were used to build a 3D model of the edifice using structure-from-motion techniques. A first dataset includes 1561 images extracted every 2 seconds from the videos.  The images are time-stamped and linked to a navigation file, which is generated by interpolating navigation data at the corresponding timestamps. A second dataset includes a 3D textured model of the site (obj format) together with the a kml file for georeferencing. The ROV navigation file (.txt) is provided separately.
Point :   37.2921244612 (lat) -32.2750499167 (long) -1612.34 (depth)
DOI: 10.6084/m9.figshare.24559246
title: Association between sex hormones and anti-S/RBD antibody responses to COVID-19 vaccines in healthcare workers

description: Healthcare workers (HCWs) are the target population for vaccination against coronavirus disease (COVID-19) as they are at a high risk of exposure and transmission of pathogens to patients. Neutralizing antibodies developed after COVID-19 vaccination decline within few months of vaccination. Several factors, including age and sex, can affect the intensity, efficacy, and duration of immune response to vaccines. However, sex-specific analyses of humoral responses to COVID-19 vaccines are lacking. This study aimed to evaluate sex-based differences in anti-S/RBD (Receptor Binding Domain) responses at three different time points after the second dose of mRNA COVID-19 vaccine in HCWs in relation to age, and to investigate the role of sex hormones as potential markers of response. Anti-S/RBD levels after two doses of the mRNA vaccine were collected from 521 HCWs naïve to COVID-19, working at two Italian Clinical Centers. Multiple regression analysis was applied to evaluate the association between anti-S levels and sex, age, and plasma levels of sex hormones. Significantly higher anti-S/RBD response to the COVID-19 vaccination was found in female HCWs, and a significant and more abrupt decline in response with time was observed in women than that in men. A novel, positive association of testosterone plasma levels and higher anti-S levels in male HCWs was found, suggesting its potential role as sex specific marker in males. In conclusion, understanding the sex-based differences in humoral immune responses to vaccines may potentially improve vaccination strategies and optimize surveillance programs for HCWs.
DOI: 10.17882/105903
title: Multibeam bathymetry and VHR seismic data acquired on the Lansdowne Bank, New Caledonia (SW Pacific)

description: This dataset comprises multibeam bathymetry and very high resolution seismic data acquired over the Lansdowne Bank (New Caledonia, SW Pacific), during the SEDLAB cruise. The latter was a 29 day research cruise on the French national fleet ship R/V ALIS that took place in April and May 2018. The main aim was to characterise the sedimentary dynamics and the stratigraphic architecture of the Lansdowne Bank, a partly drowned, isolated rimmed carbonate platform of around 4000 km2 located offshore New Caledonia in the SW Pacific. More than 2000 km2 of new multibeam data, 7 single-channel SPARKER seismic profiles, along with 15 rock dredges and 8 sediment gravity cores were acquired on the bank top and adjacent slopes. These data reveal that the bank is typified by an almost continuous 4 km wide reef rim located in ca. 50 m water depth, showing typical “spurs and grooves” patterns. This outer rim surrounds a paleolagoon that gently deepens towards the inner platform, reaching up to 100 m water depth. Pinnacle reefs, up to 20 m high, are common close to the external reef rim, but are also scattered within the inner platform. Surprisingly, no obvious transfer axes across the reef rims, internal channels, tidal shoals or any clear current-related bedforms were imaged on the bank top. The bank is bordered by very steep slopes showing numerous bypass features such as canyons, channels and gullies. Additionally, spectacular bank margin collapses were identified. They are evidenced by up to 10 km wide intraslope and bank edge failure scarps, resulting in a scalloped geometry of the bank margin. Scarps are associated with km-sized blocks at the base-of-slope. Integration of all surface and subsurface data, together with post-cruise sedimentological, biostratigraphic and radiometric analyses on rock and sediment samples will hopefully bring new insight into the onset, aggradation and drowning history of the platform in relation to past sea-level changes and vertical tectonic movements. We believe that such results are relevant for the understanding of carbonate slope processes as well as platform-to-basin sediment budgets.
DOI: 10.6084/m9.figshare.24458914.v1
title: Characteristics and economic burden of hospitalized patients with herpes zoster in China, before vaccination

description: Herpes zoster (HZ) brings a significant economic burden. The HZ vaccine was introduced in China for the first time in 2020, and there is a lack of up-to-date information on the hospitalization costs and characteristics prior to vaccination. This study aimed to describe the characteristics and economic burden of HZ inpatients in Hunan Province, China, and analyze the factors influencing the length of stay (LOS) and costs. This was a retrospective study and we extracted information from the Chinese National Health Statistics Network Reporting System on HZ inpatients in Hunan Province, China from 2017 to 2019. Spatial join tools and Global or Local Moran’s Index were used for the geographic analysis of hospitalized HZ incidence. Multivariate linear regression models were used to analyze the factors influencing LOS and costs. There were 44,311 HZ inpatients included in this study, incurring a total of $31,857,734 medical costs. These patients had a median LOS of 8 days and a median expenditure of $573.47. Older age, more comorbidities, and the presence of complications with nervous system involved were all significantly associated with longer LOS and higher costs. HZ infection resulted in a large direct medical cost and heavy disease burden, especially in patients with advanced age or underlying medical conditions. The HZ vaccine has the potential to effectively reduce the disease burden and should be widely popularized especially among high-risk groups.
DOI: 10.17882/106048
title: Dataset from a mesocosm experiment assessing the effects of a simulated terrestrial runoff on the plankton food web in a Mediterranean lagoon

description: Due to climate change, the frequency and intensity of extreme rainfall events are increasing in the Mediterranean region. As a result, terrestrial runoffs are expected to occur more frequently in the future, potentially impacting coastal aquatic ecosystems. The aim of this study was to assess the effects of a simulated terrestrial runoff on all components of the planktonic food web.
In May 2021, an in situ mesocosm experiment was conducted in the Mediterranean Thau Lagoon. To simulate terrestrial runoff within the mesocosms, a mixture of forest soil (collected from the Puéchabon state forest; 43°44’29’’N, 3°35’45’’E) and river water (from the La Vène River; 43°30'56.4"N, 3°41'33.5"E) was added.
For 18 consecutive days, we monitored planktonic communities in both control and runoff-simulated mesocosms to determine their responses. The dataset resulting from this experiment include:
 - chlorophyll-a concentrations measured by HPLC,
 - cytometric populations (viruses, bacteria, cyanobacteria, picophytoplankton, nanophytoplankton, and heterotrophic nanoflagellates),
 - taxonomic composition and abundances of phytoplankton and protozooplankton identified using an inverted microscope,
 - taxonomic abundances of metazooplankton assessed using a macroscope.
DOI: 10.6084/m9.figshare.24458914
title: Characteristics and economic burden of hospitalized patients with herpes zoster in China, before vaccination

description: Herpes zoster (HZ) brings a significant economic burden. The HZ vaccine was introduced in China for the first time in 2020, and there is a lack of up-to-date information on the hospitalization costs and characteristics prior to vaccination. This study aimed to describe the characteristics and economic burden of HZ inpatients in Hunan Province, China, and analyze the factors influencing the length of stay (LOS) and costs. This was a retrospective study and we extracted information from the Chinese National Health Statistics Network Reporting System on HZ inpatients in Hunan Province, China from 2017 to 2019. Spatial join tools and Global or Local Moran’s Index were used for the geographic analysis of hospitalized HZ incidence. Multivariate linear regression models were used to analyze the factors influencing LOS and costs. There were 44,311 HZ inpatients included in this study, incurring a total of $31,857,734 medical costs. These patients had a median LOS of 8 days and a median expenditure of $573.47. Older age, more comorbidities, and the presence of complications with nervous system involved were all significantly associated with longer LOS and higher costs. HZ infection resulted in a large direct medical cost and heavy disease burden, especially in patients with advanced age or underlying medical conditions. The HZ vaccine has the potential to effectively reduce the disease burden and should be widely popularized especially among high-risk groups.
DOI: 10.6084/m9.figshare.24886337
title: Long-lasting complete response to SHR-1701 plus famitinib in refractory advanced gallbladder cancer: A case report

description: Biliary tract cancer (BTC) is an aggressive malignancy with few options for advanced-stage treatment. The combination of PD-1/PD-L1 inhibitors with famitinib, a receptor tyrosine kinase (RTK) inhibitor, has demonstrated improved clinical outcomes in several clinical trials. We herein reported a case of a gallbladder cancer (GBC) patient with liver metastases, previously resistant to traditional chemotherapy. Remarkably, the patient achieved a complete response (CR) with a long-lasting survival benefit exceeding 3 years. This was achieved using a novel regimen combining SHR-1701, an anti-PD-L1/TGF-βR fusion protein, and famitinib, even though the patient had proficient mismatch repair (pMMR) and tested negative for PD-L1. Adverse events were limited and manageable. This is the first report of such a treatment regimen being applied in a clinical setting, suggesting that the SHR-1701 and famitinib combination may be a promising immunotherapeutic approach for patients with refractory advanced GBC.
DOI: 10.6084/m9.figshare.24886337.v1
title: Long-lasting complete response to SHR-1701 plus famitinib in refractory advanced gallbladder cancer: A case report

description: Biliary tract cancer (BTC) is an aggressive malignancy with few options for advanced-stage treatment. The combination of PD-1/PD-L1 inhibitors with famitinib, a receptor tyrosine kinase (RTK) inhibitor, has demonstrated improved clinical outcomes in several clinical trials. We herein reported a case of a gallbladder cancer (GBC) patient with liver metastases, previously resistant to traditional chemotherapy. Remarkably, the patient achieved a complete response (CR) with a long-lasting survival benefit exceeding 3 years. This was achieved using a novel regimen combining SHR-1701, an anti-PD-L1/TGF-βR fusion protein, and famitinib, even though the patient had proficient mismatch repair (pMMR) and tested negative for PD-L1. Adverse events were limited and manageable. This is the first report of such a treatment regimen being applied in a clinical setting, suggesting that the SHR-1701 and famitinib combination may be a promising immunotherapeutic approach for patients with refractory advanced GBC.