cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.31329109
title: Proximity Mapping of the ER Proteome Reveals Metastasis-Specific Candidate Biomarkers in Breast Cancer Cell lines

description: Breast cancer is the most frequently diagnosed cancer among women and a leading cause of cancer-related mortality worldwide. Biomarkers play a pivotal role in early detection, prognosis and therapeutic targeting; however, current biomarkers lack sufficient specificity and sensitivity, highlighting the need for novel, robust candidates. The endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, post-translational modification and lipid metabolism. Alterations in the ER proteome are closely associated with tumor progression, invasion and metastasis. We performed a comparative analysis of the ER proteome in non-invasive MCF-7 and invasive, metastatic MDA-MB-231 breast cancer cell lines using an ER-targeted TurboID proximity-labelling approach. This strategy enabled efficient and specific biotinylation of ER proteins, overcoming limitations of conventional methods. LC–MS/MS analyses identified a total of 2079 proteins, including 1378 ER-associated proteins. To ensure reliability, proteins with at least two unique peptides were considered, yielding 403 ER-resident and 771 ER-associated proteins. Comparative analysis revealed 185 ER-resident proteins that were upregulated and 28 that were downregulated in invasive MDA-MB-231 cells, of which 116 upregulated and 12 downregulated proteins were associated with invasion and metastasis, highlighting key molecular differences underlying the aggressive phenotype. Among more than four hundred regulated proteins, upregulated ones were associated with cellular localization, protein folding, ER stress, vesicle transport, migration, adhesion, hydrolase activity and extracellular matrix organization, reflecting aggressive tumor behaviour, whereas downregulated proteins were primarily involved in aerobic respiration, indicating altered metabolic activity. Additionally, with this study, many candidate biomarkers for breast cancer through transcriptomic and bioinformatic analyses were examined at the protein level and demonstrating their relevance to breast cancer Notably, 36 ER proteins were identified as novel candidate proteins that had not previously been linked to breast cancer. These findings provide the first protein-level evidence of ER proteome remodelling during breast cancer invasion and metastasis. Overall, ER-targeted proximity labelling offers a powerful strategy to uncover functionally relevant proteomic alterations and identify novel biomarkers with clinical potential.
DOI: 10.6084/m9.figshare.31329109.v1
title: Proximity Mapping of the ER Proteome Reveals Metastasis-Specific Candidate Biomarkers in Breast Cancer Cell lines

description: Breast cancer is the most frequently diagnosed cancer among women and a leading cause of cancer-related mortality worldwide. Biomarkers play a pivotal role in early detection, prognosis and therapeutic targeting; however, current biomarkers lack sufficient specificity and sensitivity, highlighting the need for novel, robust candidates. The endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, post-translational modification and lipid metabolism. Alterations in the ER proteome are closely associated with tumor progression, invasion and metastasis. We performed a comparative analysis of the ER proteome in non-invasive MCF-7 and invasive, metastatic MDA-MB-231 breast cancer cell lines using an ER-targeted TurboID proximity-labelling approach. This strategy enabled efficient and specific biotinylation of ER proteins, overcoming limitations of conventional methods. LC–MS/MS analyses identified a total of 2079 proteins, including 1378 ER-associated proteins. To ensure reliability, proteins with at least two unique peptides were considered, yielding 403 ER-resident and 771 ER-associated proteins. Comparative analysis revealed 185 ER-resident proteins that were upregulated and 28 that were downregulated in invasive MDA-MB-231 cells, of which 116 upregulated and 12 downregulated proteins were associated with invasion and metastasis, highlighting key molecular differences underlying the aggressive phenotype. Among more than four hundred regulated proteins, upregulated ones were associated with cellular localization, protein folding, ER stress, vesicle transport, migration, adhesion, hydrolase activity and extracellular matrix organization, reflecting aggressive tumor behaviour, whereas downregulated proteins were primarily involved in aerobic respiration, indicating altered metabolic activity. Additionally, with this study, many candidate biomarkers for breast cancer through transcriptomic and bioinformatic analyses were examined at the protein level and demonstrating their relevance to breast cancer Notably, 36 ER proteins were identified as novel candidate proteins that had not previously been linked to breast cancer. These findings provide the first protein-level evidence of ER proteome remodelling during breast cancer invasion and metastasis. Overall, ER-targeted proximity labelling offers a powerful strategy to uncover functionally relevant proteomic alterations and identify novel biomarkers with clinical potential.
DOI: 10.15468/dl.rn5fkb
title: Occurrence Download

description: A dataset containing 1976 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Peltophorum dubium",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is Fossil"
 ]
 }
 }
 ]
}

 The dataset includes 1976 records from 173 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0012401-260208012135463/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.4scduy
title: Occurrence Download

description: A dataset containing 16500 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Torgos tracheliotos (J.R.Forster, 1796)"
 ]
}

 The dataset includes 16500 records from 23 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0172206-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.c6fcvf
title: Occurrence Download

description: A dataset containing 3413 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Belenois creona severina (Stoll, 1781)"
 ]
}

 The dataset includes 3413 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0254231-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ueagj3
title: Occurrence Download

description: A dataset containing 1045 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Rhododendron arboreum Sm."
 ]
}

 The dataset includes 1045 records from 81 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0263874-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.xjjnwg
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Calliandra emarginata (Humb. & Bonpl. ex Willd.) Benth.",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0196191-220831081235567/datasets/export for details.
DOI: 10.15468/dl.tmdnbp
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Annona atemoya Mabb.",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0196198-220831081235567/datasets/export for details.
DOI: 10.15468/dl.sc2b3r
title: Occurrence Download

description: A dataset containing 757 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Eronia leda (Boisduval, 1847)"
 ]
}

 The dataset includes 757 records from 29 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0254247-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.x9ah68
title: Occurrence Download

description: A dataset containing 208 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Hynobius tsuensis Abé, 1922",
 "HasCoordinate is true",
 "Country is Japan",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 208 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0185826-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id327857.1
title: StrainInfo SI-ID 327857.1

description: StrainInfo dataset 327857 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327732.1
title: StrainInfo SI-ID 327732.1

description: StrainInfo dataset 327732 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327733.1
title: StrainInfo SI-ID 327733.1

description: StrainInfo dataset 327733 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327734.1
title: StrainInfo SI-ID 327734.1

description: StrainInfo dataset 327734 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327735.1
title: StrainInfo SI-ID 327735.1

description: StrainInfo dataset 327735 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327779.1
title: StrainInfo SI-ID 327779.1

description: StrainInfo dataset 327779 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327780.1
title: StrainInfo SI-ID 327780.1

description: StrainInfo dataset 327780 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327781.1
title: StrainInfo SI-ID 327781.1

description: StrainInfo dataset 327781 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327858.1
title: StrainInfo SI-ID 327858.1

description: StrainInfo dataset 327858 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327859.1
title: StrainInfo SI-ID 327859.1

description: StrainInfo dataset 327859 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327860.1
title: StrainInfo SI-ID 327860.1

description: StrainInfo dataset 327860 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327736.1
title: StrainInfo SI-ID 327736.1

description: StrainInfo dataset 327736 about a strain of Neurospora intermedia. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327737.1
title: StrainInfo SI-ID 327737.1

description: StrainInfo dataset 327737 about a strain of Neurospora sitophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327738.1
title: StrainInfo SI-ID 327738.1

description: StrainInfo dataset 327738 about a strain of Neurospora sitophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327782.1
title: StrainInfo SI-ID 327782.1

description: StrainInfo dataset 327782 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327783.1
title: StrainInfo SI-ID 327783.1

description: StrainInfo dataset 327783 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327784.1
title: StrainInfo SI-ID 327784.1

description: StrainInfo dataset 327784 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327785.1
title: StrainInfo SI-ID 327785.1

description: StrainInfo dataset 327785 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327861.1
title: StrainInfo SI-ID 327861.1

description: StrainInfo dataset 327861 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327862.1
title: StrainInfo SI-ID 327862.1

description: StrainInfo dataset 327862 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327863.1
title: StrainInfo SI-ID 327863.1

description: StrainInfo dataset 327863 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327864.1
title: StrainInfo SI-ID 327864.1

description: StrainInfo dataset 327864 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.15468/dl.ybnw35
title: Occurrence Download

description: A dataset containing 3144 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Continent is Europe",
 "License is CC-BY-NC 4.0",
 "TaxonKey is Pinicola enucleator (Linnaeus, 1758)"
 ]
}

 The dataset includes 3144 records from 27 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0085446-240506114902167/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.60712/si-id327739.1
title: StrainInfo SI-ID 327739.1

description: StrainInfo dataset 327739 about a strain of Neurospora sitophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327740.1
title: StrainInfo SI-ID 327740.1

description: StrainInfo dataset 327740 about a strain of Neurospora sitophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327741.1
title: StrainInfo SI-ID 327741.1

description: StrainInfo dataset 327741 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327742.1
title: StrainInfo SI-ID 327742.1

description: StrainInfo dataset 327742 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327786.1
title: StrainInfo SI-ID 327786.1

description: StrainInfo dataset 327786 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327787.1
title: StrainInfo SI-ID 327787.1

description: StrainInfo dataset 327787 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327788.1
title: StrainInfo SI-ID 327788.1

description: StrainInfo dataset 327788 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327789.1
title: StrainInfo SI-ID 327789.1

description: StrainInfo dataset 327789 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327865.1
title: StrainInfo SI-ID 327865.1

description: StrainInfo dataset 327865 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327866.1
title: StrainInfo SI-ID 327866.1

description: StrainInfo dataset 327866 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327867.1
title: StrainInfo SI-ID 327867.1

description: StrainInfo dataset 327867 about a strain of Neurospora sitophila. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327868.1
title: StrainInfo SI-ID 327868.1

description: StrainInfo dataset 327868 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327743.1
title: StrainInfo SI-ID 327743.1

description: StrainInfo dataset 327743 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327744.1
title: StrainInfo SI-ID 327744.1

description: StrainInfo dataset 327744 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327745.1
title: StrainInfo SI-ID 327745.1

description: StrainInfo dataset 327745 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327790.1
title: StrainInfo SI-ID 327790.1

description: StrainInfo dataset 327790 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327791.1
title: StrainInfo SI-ID 327791.1

description: StrainInfo dataset 327791 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
DOI: 10.60712/si-id327792.1
title: StrainInfo SI-ID 327792.1

description: StrainInfo dataset 327792 about a strain of Neurospora crassa. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.