cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24754047.v1
title: Supplementary Material for: Clinical characteristics of pathogenic ACAN variants and 3-year response to growth hormone treatment: real-world data

description: Introduction Heterozygous variants in the ACAN gene may underlie disproportionate short stature with characteristically accelerated bone age (BA) maturation and/or early-onset osteoarthritis (OA). Methods To describe phenotype, analyze genotype-phenotype correlations and assess the response of growth hormone (GH) treatment in children with a heterozygous ACAN variant. Thirty-six subjects (23 boys, 13 girls) with ACAN-deficiency and treated for ≥1 year with GH were identified in the Dutch National Registry of GH treatment in children. Results We identified 25 different heterozygous ACAN variants in 36 subjects. Median (IQR) height SDS at start of GH was -2.6 SDS (-3.2 to -2.2). Characteristic features such as disproportion, advanced BA, early-onset OA and dysmorphic features like midface hypoplasia and brachydactyly were present in the majority of children, but in ~20% no specific features were reported. Subjects with a truncating ACAN variant had a shorter height SDS compared to subjects with a non-truncating variant (-2.8 SDS and -2.1 SDS respectively, P=0.002). After 3 years of GH, height gain SDS in prepubertal children was 1.0 SDS (0.9 to 1.4). In pubertal children, height SDS remained relatively stable. Conclusion The phenotype of subjects with pathogenic heterozygous ACAN variants is highly variable and genetic testing for ACAN-deficiency should be considered in any child with significant short stature, even in the absence of disproportion, specific dysmorphic features or bone-age advancement. Furthermore, children with ACAN-deficiency may benefit from GH with a modest but significant response, which is sustained during 3 years of treatment.
DOI: 10.15468/dl.z9gfe5
title: Occurrence Download

description: A dataset containing 228 species occurrences available in GBIF matching the query:
{
 "and" : [
 "HasGeospatialIssue is false",
 "HasCoordinate is true",
 "OccurrenceStatus is Present",
 {
 "not" : {
 "BasisOfRecord" : [
 "is one of (Observation, Human Observation, Machine Observation, Living Specimen)"
 ]
 }
 },
 "TaxonKey is Epinotia demarniana (Fischer von Röslerstamm, 1839)"
 ]
}

 The dataset includes 228 records from 26 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009444-250426092105405/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.6084/m9.figshare.5311153.v1
title: Osteology of the Middle Triassic stem-turtle <i>Pappochelys rosinae</i> and the early evolution of the turtle skeleton

description: <i>Pappochelys</i> extends the fossil record of Triassic stem-turtles back by some 20 million years, and provides important new insights into how and in what sequence the key features of turtles arose. It shares various derived features with the early Late Triassic stem-turtle <i>Odontochelys</i>, such as T-shaped ribs, a short trunk, and features of the girdles and limbs. At the same time, it is more plesiomorphic in retaining a fully diapsid skull and in lacking both neurals and a plastron with plate-like elements. <i>Pappochelys</i> provides important new evidence that the carapace and plastron of turtles are distinct moieties that evolved independently from each other. The skull of <i>Pappochelys</i> is more or less triangular in plan view. The marginal dentition comprises peg-like teeth with subthecodont implantation. Whereas the upper temporal fenestra is relatively small and rounded, the lower temporal opening is large and ventrally open. The slender vomers are fused. The vertebral column of <i>Pappochelys</i> comprises probably eight cervical, probably nine dorsal, two sacral, and more than 24 caudal vertebrae. The dorsal ribs have asymmetrical anterior and posterior flanges and their external surfaces are heavily ornamented. The gastralia form pairs of robust elements, one per vertebral segment. The scapula has a slender dorsal shaft and a rounded ‘acromial’ flange. The humerus has a slightly dorsally raised proximal head and a gently sigmoidal curvature. The pubis closely resembles that of <i>Odontochelys</i> in overall shape and has a well-developed lateral process. We performed a phylogenetic analysis using a modified character-taxon matrix (272 characters, 50 taxa) from a recent study to assess the placement of <i>Pappochelys</i> among amniotes. <i>Pappochelys</i> was found to nest among Pantestudines with <i>Eunotosaurus</i> and the more derived <i>Odontochelys</i> and <i>Proganochelys</i>. The diapsid affinities of turtles are well supported but it is still unresolved whether turtles are saurians or only related to the latter.
DOI: 10.6084/m9.figshare.27925419.v2
title: Space-Time Optical Diffraction from Synthetic Motion

description: Space-time diffraction efficiency as a function of pump-probe delay (Fig.2b)Probe pulse duration and spectral width as a function of 4f slit aperture width (Fig.S2b)
DOI: 10.6084/m9.figshare.4800895.v1
title: Supplementary Data for 'Rape: is there an app for that? An empirical analysis of the features of anti-rape apps'

description: This table contains a list of all of the mobile phone applications (apps) investigated, along with the name of the developer, URL(s), and any additional notes.
DOI: 10.6084/m9.figshare.15167181.v1
title: Imaris Imaging Data

description: All HLB positions used to compute intensity and volumes from each individual microscopy channel
DOI: 10.6084/m9.figshare.28449953.v1
title: Aridity_Grazing_plant_arthropod data J Arid Environ

description: Data from the aridity-dependent grazing effects on plant communities (plant species richness and community-weighted mean of plant height) and ground-dwelling arthropod communites (the abundance of herbivore, detritivore and omnivore) in Mongolian grasslands.
DOI: 10.17632/8ftcj8bp2g.1
title: CFTR modulator therapy impacts neutrophil CD39 expression in cystic fibrosis - Supplemental Data and Methodology

description: Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Levels of eATP are tightly regulated through direct hydrolysis via the action of cell surface ectonucleotidases including CD39, however, a role for CD39 as an influencer of inflammation in CF is underexplored. 
In the present study we sought to evaluate the impact of CFTR modulator therapy on eATP levels and CD39 expression. Detailed protocols of this study are outlined in the online Supplementary Methodology File. A flow chart of patients' samples processed and experiments analysed is presented in Supplementary Data File (Supplemental Figure 1). 
To understand the basis for increased eATP release by CF neutrophils, we assessed membrane CD39 levels. 
Prompted by results suggesting cleavage of membrane CD39 from CF neutrophils, we investigated the protease involved in CD39 release. In light of previous published findings of increased release of neutrophil elastase (NE) by CF neutrophils, we hypothesized that NE may cleave CD39, an effect potentially abated by inclusion of the NE inhibitor, alpha-1 antitrypsin (AAT). In support of this theory, recombinant NE cleaved CD39 from healthy control cells in vitro (Supplemental Figure 2). 
This study concludes by stating that extracellular nucleotides were previously detected in sputum and BAL fluid of patients with CF, and in the current study correlated with sputum neutrophil counts. In the current study apparent proteolytic cleavage decreased membrane expression of CD39. Accordingly, sCD39 was detected in CF airway and plasma samples.
DOI: 10.21942/uva.16844500.v1
title: Ahead Brain 122017 - Original stains

description: A multimodal 3D reconstruction of the whole human brain at a 200 micrometer scale created by fusing ultra-high field MRI and light microscopy.<br>This repository includes the original microscopy stains at the 1200dpi resolution. For convenience, large stacks are subdivided into frontal, medial, and occipital groupings. 2D mappings between stains and the blockface image are also included.
DOI: 10.6084/m9.figshare.14270663.v1
title: Raw_data_Goes_et_al_2021.xlsx

description: All scored behaviors obtained, studied and discussed in Goes et al. 2021. Access to all treatment and controls responses, in all the exposures.
DOI: 10.6084/m9.figshare.21214460.v1
title: SFS-based admixture history reconstruction

description: Zipped folder containing all input files, site frequency spectra and accessory scripts for admixture history reconstruction using fastsimcoal2 in Nouhaud et al. (https://doi.org/10.1101/2022.01.16.476493). See README files for more information on the content of each folder.
DOI: 10.6084/m9.figshare.3520961.v1
title: Appendix C. ANCOVA results for the association between quantitative measures of grazing intensity and community composition.

description: ANCOVA results for the association between quantitative measures of grazing intensity and community composition.
DOI: 10.6084/m9.figshare.8094515.v3
title: Model files for CTseg

description: These are the model files for the CTseg toolbox of SPM12, used to segment computed tomography (CT) scans. The toolbox is available at: https://github.com/WCHN/CTseg<br>
DOI: 10.6084/m9.figshare.15167022.v4
title: Predictor retinopaty in T2DM patients

description: <b>Background and aims</b>: Diabetic retinopathy is a long-term complication of diabetes that is the most common complication of diabetes which is the leading cause of vision loss. The objective of this study is to discover retinopathy predictors, early detection of risk factors, and improved problem management in patients with type 2 diabetes in Medan.<strong>Method:</strong> <strong>This analytic cross-sectional study included 89 patients (60 non-retinopathy and 29 retinopathy patients). An indirect funduscopic revealed the presence of DR. Blood analysis was used to assess blood Glucose level, HbA1C, Alipoprotein-A1 (Apo-A1), Total Cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglyceride, and Vitamin D levels. Urine analysis was used to determine albuminuria using the albumin creatinine ratio (ACR). Each predictor's link with DR was determined using bivariate analysis, the Independent t-test, and the Mann–Whitney U test. The logistic regression test was used for multivariate analysis (p&lt;0.05).</strong><b></b><strong>Result:</strong> The retinopathy predictive model revealed that BGL, TC, and ACR were strong predictors, whereas hypertension, LDL-C, and Triglycerides were weak predictors.<strong>Conclusion</strong>: Increased BGL, total cholesterol, and ACR are solid markers for the occurrence of DR complications, in that type 2 DM patients should be aware of these predictors. Education efforts and increasing patient independence need to be carried out continuously to prevent other advanced chronic complications.<b> </b>
DOI: 10.6084/m9.figshare.21220949.v1
title: Dataset Cumulative CO2 Emissions of International Transport

description: This dataset considers the year 1783, when the first steamship was built, as the first year of the international transport CO2 emissions. The global cumulative CO2 emissions including international transport are converted to the 1875 baseline, similar to the Global Warming baseline (1850-1900).
DOI: 10.6084/m9.figshare.22362385.v2
title: Global Land ET by CR method Version 2.0

description: This is the global land surface evapotranspiration dataset (Version 2.0) produced by the calibration-free Complementary Relationship (CR) method. The dataset now covers the period of 2000-2022 with spatial and temporal resolutions of 0.25-degree and monthly, respectively. Note that it could not be combined with the Version 1.0 for a longer temporal period since Version 2.0 was driven by different forcings and by different parameter values. For users who are interested in ET during the post-2000 period, the Version 2.0 is highly suggested. Please read the "README_V2.0" file for details.
DOI: 10.6084/m9.figshare.26247131.v1
title: Supplementary Material for: Yoga as a complementary therapy for cancer patients: from clinical observations to biochemical mechanisms

description: Background: Integrative oncology combines conventional and complementary, or integrative, therapies for a holistic treatment of cancer patients. Yoga is increasingly used as a complementary therapy for cancer patients, but there is no direct evidence for its effect on cancer pathophysiology like tumor response, or patient outcome like overall survival. 
Summary: In this narrative review, we present in detail published studies from randomized clinical trials on complementary yoga therapy for cancer patients, including details about the biochemical mechanisms involved. Medicinal hatha yoga with breathing, postures, meditation, and relaxation enhances the quality of life of cancer patients by providing both psychological and physiological health benefits, highlighting the interconnectedness of mind and body. Yoga therapy reduces stress levels improving heart rate variability, leading to changes in hormonal regulation (e.g. cortisol), reduced oxidative stress and improved immune function with reduced inflammation. Still, the biochemical effects of yoga on the cancer disease itself are unrevealed.
Key messages: More clinical and basic research is needed for further establishment of yoga as complementary therapy in oncology.
DOI: 10.6084/m9.figshare.20465688.v1
title: Lebreton_DutchPopulation_No12

description: Data used for Vulnerability
DOI: 10.17632/k4yrmr5j6k.1
title: Models, topographic profiles, and data for 'Geometric forward modeling of thrust systems underlying shortening landforms on Mercury.'

description: This zip file contains within it the 55 geometric forward models of the underlying structure of thrust fault related landforms across Mercury's surface and all of their relevant data as described in the manuscript 'Geometric forward modeling of thrust systems underlying shortening landforms on Mercury.' This dataset contains a .csv file with the final compilation of the parameters collected across all of the geometric models created by the MOVE software from Petroleum Experts. This dataset also contains a folder directory labeled 'Fault Models' which contain folders to all of the models created with the MOVE software. Each subsequent folder titled 'Fault #' contains the .move model file, the required .movd relevant model data, and the .csv file of the topographic profile used to construct the respective model. Each Fault number (#) corresponds to the same fault number in the fault map shapefile and data table in our dataset with measurements of morphologic parameters of thrust fault-related landforms. This previous dataset was published as Loveless et al., 2024 ‘Code and Data for 'A statistical evaluation of the morphological variability of shortening landforms on Mercury.', Revised’ (doi: 10.17632/8968vkgpds.2; https://data.mendeley.com/datasets/8968vkgpds/2) and is discussed and analyzed in Loveless, et al. (2024). A statistical evaluation of the morphological variability of shortening landforms on Mercury. Icarus 416, 116106. https://doi.org/10.1016/j.icarus.2024.116106.
DOI: 10.6084/m9.figshare.19499132.v1
title: patches and local annotations, slide 190, zoom 248x248 um2

description: patches and local annotations: data for slide with ID of the last 3 characters of the file name: local annotations in csv format and a folder with patches at zoom level indicated at the 6th character of the file name
DOI: 10.17632/k4yrmr5j6k.2
title: Models, topographic profiles, and data for 'Geometric forward modeling of thrust systems underlying shortening landforms on Mercury.'

description: This zip file contains within it the 55 geometric forward models of the underlying structure of thrust fault related landforms across Mercury's surface and all of their relevant data as described in the manuscript 'Geometric forward modeling of thrust systems underlying shortening landforms on Mercury.' This dataset contains a .csv file with the final compilation of the parameters collected across all of the geometric models created by the MOVE software from Petroleum Experts. This dataset also contains a folder directory labeled 'Fault Models' which contain folders to all of the models created with the MOVE software. Each subsequent folder titled 'Fault #' contains the .move model file, the required .movd relevant model data, and the .csv file of the topographic profile used to construct the respective model. Each Fault number (#) corresponds to the same fault number in the fault map shapefile and data table in our dataset with measurements of morphologic parameters of thrust fault-related landforms. This previous dataset was published as Loveless et al., 2024 ‘Code and Data for 'A statistical evaluation of the morphological variability of shortening landforms on Mercury.', Revised’ (doi: 10.17632/8968vkgpds.2; https://data.mendeley.com/datasets/8968vkgpds/2) and is discussed and analyzed in Loveless, et al. (2024). A statistical evaluation of the morphological variability of shortening landforms on Mercury. Icarus 416, 116106. https://doi.org/10.1016/j.icarus.2024.116106.
DOI: 10.6084/m9.figshare.3084517.v1
title: perforation.xls

description: colorectal perforation dataset for publication in BMC
DOI: 10.6084/m9.figshare.21862554.v1
title: bilirubin

description: Su tuong hop giua 2 phuong phap bieu do Bland Altmann
DOI: 10.6084/m9.figshare.8845832.v1
title: Data for: Synergistic and antagonistic effects of land use and non-native species on community responses to climate change

description: This is the dataset for the following publication: <br>Auffret, A.G., Thomas, C.D. 2019, Synergistic and antagonistic effects of land use and non-native species on community responses to climate change,<i> Global Change Biology</i>. https://doi.org/10.1111/gcb.14765<br>The dataset comprises data for the analysis of change in (plant) community climate indices (temperature and precipitation) in 996 Swedish landscapes during the 20th century, and the effects of changes in climate, land use and the proportions of non-native species in driving community change.<br>We also publish species temperature and precipitation indices for 3053 Swedish plant species. <br><br>Please consult the readme and the published article for further details. Feel free to get in touch.<br>Alistair Auffret - alistair.auffret@slu.se.<br><br><br>
DOI: 10.11583/dtu.24460090.v1
title: IEA-15MW-RWT HAWC2-Monopile Response Database

description: The IEA-15MW-RWT-Monopile HAWC2 Response Database contains simulated aeroelastic response data for the IEA 15 MW Reference Wind Turbine with monopile foundation]. The purpose of the database is to provide open access to realistic wind turbine response data, environmental data, and operational data that researchers across different institutions can use freely for whatever purpose they see fit. The content of the database and its background are described in the document IEA-15MW-RWT-Monopile HAWC2 Response Database.pdf, found in this dataset.This dataset contains the following files:<br>- readme.txt<br>- IEA-15MW-RWT-Monopile HAWC2 Response Database.pdf<br>- HAWC2.zip<br>- DLC12_wavedir-22_LAT.zip<br>- DLC12_wavedir000_LAT.zip<br>- DLC12_wavedir022_LAT.zip<br>- DLC12_wavedir-22_MSL.zip<br>- DLC12_wavedir000_MSL.zip<br>- DLC12_wavedir022_MSL.zip<br>- DLC12_wavedir-22_HAT.zip<br>- DLC12_wavedir000_HAT.zip<br>- DLC12_wavedir022_HAT.zip<br>- DLC24.zip<br>- DLC31.zip<br>- DLC41.zip<br>- DLC64_LAT.zip<br>- DLC64_MSL.zip<br>- DLC64_HAT.zip<br>- DLC72_LAT_lockedrotor00.zip<br>- DLC72_LAT_lockedrotor30.zip<br>- DLC72_LAT_lockedrotor60.zip<br>- DLC72_LAT_lockedrotor90.zip<br>- DLC72_MSL_lockedrotor00.zip<br>- DLC72_MSL_lockedrotor30.zip<br>- DLC72_MSL_lockedrotor60.zip<br>- DLC72_MSL_lockedrotor90.zip<br>- DLC72_HAT_lockedrotor00.zip<br>- DLC72_HAT_lockedrotor30.zip<br>- DLC72_HAT_lockedrotor60.zip<br>- DLC72_HAT_lockedrotor90.zip
DOI: 10.6084/m9.figshare.19106867.v1
title: Supplementary Material for: miR-126-5p Targets SP1 to Inhibit the Progression of Parkinson’s Disease

description: <b><i>Background:</i></b> At present, symptomatic treatment may improve the life quality of Parkinson’s disease (PD) patients to a certain extent but cannot completely cure PD. Therefore, it is urgent medical problem to be solved for improving the efficacy and safety of PD treatment. <b><i>Methods:</i></b> SH-SY5Y and SK-N-SH cells were treated with 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>) to establish PD model cells. miR-126-5p and specific protein-1 (SP1) expression levels were detected by quantitative Real-Time PCR (qRT-PCR). Western blot was applied to measure protein levels of SP1, Bax, and Bcl-2. The viabilities and apoptosis rates of treated cells were measured using cell counting kit-8 assay and flow cytometry analysis. Enzyme-linked immunosorbent assay was performed to measure TNF-α and IL-1β releases. Interaction between miR-126-5p and SP1 was examined by dual-luciferase reporter assay. <b><i>Results:</i></b> MPP<sup>+</sup> treatment greatly downregulated miR-126-5p expression while upregulated SP1 expression in SH-SY5Y and SK-N-SH cells in a time- and does-dependent manner. Overexpression of miR-126-5p facilitated cell viability, while reduced cell apoptosis and inflammatory responses induced by MPP<sup>+</sup> treatment. Moreover, SP1 was a target of miR-126-5p and could be negatively regulated by miR-126-5p. Overexpression of SP1 could reverse the effects of miR-126-5p on MPP<sup>+</sup>-administrated cells. <b><i>Conclusion:</i></b> Our results suggested that miR-126-5p attenuated the neurotoxicity induced by MPP<sup>+</sup> in vitro through targeting SP1 (Graphical abstract), which further enhanced our understanding of the pathological mechanism of PD.
DOI: 10.6084/m9.figshare.14327979.v1
title: MACRONUTRIENT RATES AND MULTIFUNCTIONAL MICROORGANISMS IN A TROPICAL FLOODED RICE CROP

description: ABSTRACT Tropical flooded rice production systems require a high input of fertilizers and chemical defensive. The use of plant growth-promoting rhizobacteria (PGPR), a sustainable component of this system, can increase nutrient-use efficiency and lead to significant increases in the grain yield of tropical flooded rice crop. This study aimed to determine the effect of the microorganism BRM 32110 (Bacillus thuringiensis) in combination with nitrogen (N), phosphorus (P) and potassium (K) application rates on the physiological and agronomic performance of tropical flooded rice plants. Trials were performed in the 2016/2017 growing season in Formoso do Araguaia, a city in Tocantins state, Brazil. Three independent experiments (E1, E2, and E3) were performed in a randomized block design in a 4 x 2 factorial scheme with three replications. E1 comprised four N application rates (0, 40, 80 and 120 kg N ha-1) with and without the addition of BRM 32110, E2 comprised four P2O5 application rates (0, 40, 80 and 120 kg P2O5 ha-1) with or without BRM 32110, and E3 comprised four K2O application rates (0, 20, 40 and 60 kg K2O ha-1) with and without BRM 32110. In fertile soil, there were no interactions between the rhizobacterium BRM 32110 and the N, P or K application rates. BRM 32110 improved nutrient uptake and, on average, increased shoot dry matter by 8%, photosynthesis rate by 14% and grain yield by 11% in the flooded rice plants. Our results suggest that the use of multifunctional microorganisms is a good strategy for improving flooded rice grain yield sustainably.