cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.3886/e192864
title: Neurophysiological correlates of interpersonal discrepancy and social adjustment in an interactive decision-making task in dyads

description: The pursuit of convergence and the social behavioral adjustment of conformity are fundamental cooperative behaviors that help people adjust their mental frameworks to reach a common goal. However, while social psychology extensively studies conformity, there is still plenty to investigate about the neural mechanisms underlying this behavior. We proposed a paradigm with two phases, a pre-activation phase to enhance cooperative tendencies and, later, a social decision-making phase where conformity happens spontaneously and synchronously through the pursuit of convergence. Study 1 shows evidence from 80 participants that the pre-activation phase enhances convergence in dyads. In Study 2, we registered in phase 2 the electroencephalographical (EEG) activity of 36 participants in which dyads had to make a perceptual estimation in three consecutive trials and converge in their decisions without an explicit request or reward to do so. Event-related Potentials (ERP) revealed signal differences in response divergence in three intervals. Time-frequency analysis showed theta, alpha, and beta evidence related to cognitive control, attention, and reward processing associated with social convergence.
description: EEG was recorded using an ANT Neuro ASALab EEG amplifier at 1024 Hz using two different elastic caps from 27 scalp electrodes (Fp1/2, Fz, F3/4, F7/8, FC1/2, FC5/6, Cz, C3/4, Cp1/2, CP5/6, Pz, P3/4, P7/8, Poz, Oz, M1/2). Eye movements were registered with an electrode associated with the participant's dominant hand at the infraorbital ridge of the eye. The electrode impedance was kept below 5kΩ during the task. The electrophysiological signal was bandpass filtered, with cut-off frequencies of 0.1 Hz to 30Hz, and re-referenced to the activity of the two mastoids. Epoch events were extracted from -2 to 2 seconds after the stimuli showing the estimated position of each participant (feedback). Independent Component Analysis (ICA) (Makeig & Onton, 2011) was used to clean artifacts and, afterwards, epochs exceeding ± 100 μV from -100 ms to 1000 ms were automatically rejected. Time-frequency (TF) analysis was also computed by convolving single trials with 7 cycle complex Morlet wavelet for frequencies ranging from 1 to 30 Hz. Changes in power were computed by dividing power value by baseline (-400 ms to -100 ms) for each electrode, frequency, and condition. The ERP/TF analysis focused on three midline electrodes (Fz, Cz and Pz) and the different time ranges were based on visual inspection of the corresponding ERPs. Statistical analysis of time-frequency data was performed in theta (4-8Hz), alpha (8-12Hz) and beta (12-30Hz) bands.
DOI: 10.3886/e192864v2
title: Neurophysiological correlates of interpersonal discrepancy and social adjustment in an interactive decision-making task in dyads

description: The pursuit of convergence and the social behavioral adjustment of conformity are fundamental cooperative behaviors that help people adjust their mental frameworks to reach a common goal. However, while social psychology extensively studies conformity, there is still plenty to investigate about the neural mechanisms underlying this behavior. We proposed a paradigm with two phases, a pre-activation phase to enhance cooperative tendencies and, later, a social decision-making phase where conformity happens spontaneously and synchronously through the pursuit of convergence. Study 1 shows evidence from 80 participants that the pre-activation phase enhances convergence in dyads. In Study 2, we registered in phase 2 the electroencephalographical (EEG) activity of 36 participants in which dyads had to make a perceptual estimation in three consecutive trials and converge in their decisions without an explicit request or reward to do so. Event-related Potentials (ERP) revealed signal differences in response divergence in three intervals. Time-frequency analysis showed theta, alpha, and beta evidence related to cognitive control, attention, and reward processing associated with social convergence.
description: EEG was recorded using an ANT Neuro ASALab EEG amplifier at 1024 Hz using two different elastic caps from 27 scalp electrodes (Fp1/2, Fz, F3/4, F7/8, FC1/2, FC5/6, Cz, C3/4, Cp1/2, CP5/6, Pz, P3/4, P7/8, Poz, Oz, M1/2). Eye movements were registered with an electrode associated with the participant's dominant hand at the infraorbital ridge of the eye. The electrode impedance was kept below 5kΩ during the task. The electrophysiological signal was bandpass filtered, with cut-off frequencies of 0.1 Hz to 30Hz, and re-referenced to the activity of the two mastoids. Epoch events were extracted from -2 to 2 seconds after the stimuli showing the estimated position of each participant (feedback). Independent Component Analysis (ICA) (Makeig & Onton, 2011) was used to clean artifacts and, afterwards, epochs exceeding ± 100 μV from -100 ms to 1000 ms were automatically rejected. Time-frequency (TF) analysis was also computed by convolving single trials with 7 cycle complex Morlet wavelet for frequencies ranging from 1 to 30 Hz. Changes in power were computed by dividing power value by baseline (-400 ms to -100 ms) for each electrode, frequency, and condition. The ERP/TF analysis focused on three midline electrodes (Fz, Cz and Pz) and the different time ranges were based on visual inspection of the corresponding ERPs. Statistical analysis of time-frequency data was performed in theta (4-8Hz), alpha (8-12Hz) and beta (12-30Hz) bands.
DOI: 10.6084/m9.figshare.24249574
title: Supplementary Material for: The Fatty Liver Index, the Strongest Risk Factor for Low Testosterone Level

description: Introduction: The study aimed to determine if hepatic steatosis assessed by Fatty Liver Index (FLI) was an independent risk factor for male testosterone insufficiencylow testosterone level and whether the FLI was the strongest risk factor for testosterone insufficiencylow testosterone level in two different age groups. Methods: Two cross-sectional studies were performed. A total of 3443 male participants (aged 46-75) were recruited into study A (part of lONgitudinal study (REACTION)). Then a total of 267 male participants (aged 25-45) were recruited into study B. Serum TT and sex hormone-binding globulin (SHBG) levels, indicators for assessing hepatic steatosis were measured. The Pearson correlation and regression analysis were performed to investigate the risk factors for testosterone insufficiencylow testosterone level. Results: The FLI had the strongest negative correlation with serum testosterone in the study A (r=-0.436) and B (r=-0.542). Compared with patients with a FLI lower than 30, the risk for testosterone insufficiencylow testosterone level increased by 3.48–fold in subjects with a FLI higher than 60 adjusted for potential risk factors in study A. In study B, the OR of testosterone insufficiencylow testosterone level in patients with potential hepatic steatosis was 4.26 (1.57-11.60) after adjusted for age and HOMA-IR, and 0.59 (0.14-2.60) after adjusted for age, HOMA-IR, waist circumference, body mass index, and SHBG. Conclusions: FLI, was the strongest risk factor for male testosterone insufficiencylow testosterone level independent of insulin resistance in a male populations of different ages, however the association can be modulated by SHBG levels in the young.
DOI: 10.6084/m9.figshare.24249577
title: Supplementary Material for: The Fatty Liver Index, the Strongest Risk Factor for Low Testosterone Level

description: Introduction: The study aimed to determine if hepatic steatosis assessed by Fatty Liver Index (FLI) was an independent risk factor for male testosterone insufficiencylow testosterone level and whether the FLI was the strongest risk factor for testosterone insufficiencylow testosterone level in two different age groups. Methods: Two cross-sectional studies were performed. A total of 3443 male participants (aged 46-75) were recruited into study A (part of lONgitudinal study (REACTION)). Then a total of 267 male participants (aged 25-45) were recruited into study B. Serum TT and sex hormone-binding globulin (SHBG) levels, indicators for assessing hepatic steatosis were measured. The Pearson correlation and regression analysis were performed to investigate the risk factors for testosterone insufficiencylow testosterone level. Results: The FLI had the strongest negative correlation with serum testosterone in the study A (r=-0.436) and B (r=-0.542). Compared with patients with a FLI lower than 30, the risk for testosterone insufficiencylow testosterone level increased by 3.48–fold in subjects with a FLI higher than 60 adjusted for potential risk factors in study A. In study B, the OR of testosterone insufficiencylow testosterone level in patients with potential hepatic steatosis was 4.26 (1.57-11.60) after adjusted for age and HOMA-IR, and 0.59 (0.14-2.60) after adjusted for age, HOMA-IR, waist circumference, body mass index, and SHBG. Conclusions: FLI, was the strongest risk factor for male testosterone insufficiencylow testosterone level independent of insulin resistance in a male populations of different ages, however the association can be modulated by SHBG levels in the young.
DOI: 10.6084/m9.figshare.24249577.v1
title: Supplementary Material for: The Fatty Liver Index, the Strongest Risk Factor for Low Testosterone Level

description: Introduction: The study aimed to determine if hepatic steatosis assessed by Fatty Liver Index (FLI) was an independent risk factor for male testosterone insufficiencylow testosterone level and whether the FLI was the strongest risk factor for testosterone insufficiencylow testosterone level in two different age groups. Methods: Two cross-sectional studies were performed. A total of 3443 male participants (aged 46-75) were recruited into study A (part of lONgitudinal study (REACTION)). Then a total of 267 male participants (aged 25-45) were recruited into study B. Serum TT and sex hormone-binding globulin (SHBG) levels, indicators for assessing hepatic steatosis were measured. The Pearson correlation and regression analysis were performed to investigate the risk factors for testosterone insufficiencylow testosterone level. Results: The FLI had the strongest negative correlation with serum testosterone in the study A (r=-0.436) and B (r=-0.542). Compared with patients with a FLI lower than 30, the risk for testosterone insufficiencylow testosterone level increased by 3.48–fold in subjects with a FLI higher than 60 adjusted for potential risk factors in study A. In study B, the OR of testosterone insufficiencylow testosterone level in patients with potential hepatic steatosis was 4.26 (1.57-11.60) after adjusted for age and HOMA-IR, and 0.59 (0.14-2.60) after adjusted for age, HOMA-IR, waist circumference, body mass index, and SHBG. Conclusions: FLI, was the strongest risk factor for male testosterone insufficiencylow testosterone level independent of insulin resistance in a male populations of different ages, however the association can be modulated by SHBG levels in the young.
DOI: 10.5281/zenodo.8263053
title: sRNA_seq_clean_thrips_leafdiscs_timeseries

description: 2023-03 Timeseries experiment with clean thrips on leafdiscs of tomato MoneyMaker plants. srna and mrna were extracted with the kit 'NucleoSpin miRNA, Mini kit for miRNA and RNA purification'.<br> contains (see metadata file for more info): - 20x leafdiscs samples as controls (5 biological replicates/wells for 4 timepoints: 3h, 6h, 9h, 12h) - 20x leafdiscs samples with thrips (5 biological replicates/wells for 4 timepoints: 3h, 6h, 9h, 12h) - 5x whole thrips feeding on leafdiscs for 12h (same experiment, as leafdiscs) - 2x the heads of thrips feeding on tomato for 24h+, i.e. salivary glands enriched samples - 2x the eggs of thrips Barcoded Small RNA-Seq libraries were generated from the small RNA according to the manufacturers’ protocols using the Small RNA-Seq Library Prep Kit (Lexogen). The size distribution of the libraries with indexed adapters was assessed using a 2200 TapeStation System with Agilent D1000 ScreenTapes (Agilent Technologies). The libraries were quantified on a QuantStudio 3 Real-Time PCR System (Thermo Fisher Scientific) using the NEBNext Library Quant Kit for Illumina (New England BioLabs) according to the instructions of the manufacturer. The libraries were clustered and sequenced (75 bp) on a NextSeq 550 Sequencing System (Illumina) using a NextSeq 500/550 High Output Kit v2.5 (75 Cycles) (Illumina). Adapter: TGGAATTCTCGGGTGCCAAGGAACTCCAGTCAC
DOI: 10.5281/zenodo.8263052
title: sRNA_seq_clean_thrips_leafdiscs_timeseries

description: 2023-03 Timeseries experiment with clean thrips on leafdiscs of tomato MoneyMaker plants. srna and mrna were extracted with the kit 'NucleoSpin miRNA, Mini kit for miRNA and RNA purification'.<br> contains (see metadata file for more info): - 20x leafdiscs samples as controls (5 biological replicates/wells for 4 timepoints: 3h, 6h, 9h, 12h) - 20x leafdiscs samples with thrips (5 biological replicates/wells for 4 timepoints: 3h, 6h, 9h, 12h) - 5x whole thrips feeding on leafdiscs for 12h (same experiment, as leafdiscs) - 2x the heads of thrips feeding on tomato for 24h+, i.e. salivary glands enriched samples - 2x the eggs of thrips Barcoded Small RNA-Seq libraries were generated from the small RNA according to the manufacturers’ protocols using the Small RNA-Seq Library Prep Kit (Lexogen). The size distribution of the libraries with indexed adapters was assessed using a 2200 TapeStation System with Agilent D1000 ScreenTapes (Agilent Technologies). The libraries were quantified on a QuantStudio 3 Real-Time PCR System (Thermo Fisher Scientific) using the NEBNext Library Quant Kit for Illumina (New England BioLabs) according to the instructions of the manufacturer. The libraries were clustered and sequenced (75 bp) on a NextSeq 550 Sequencing System (Illumina) using a NextSeq 500/550 High Output Kit v2.5 (75 Cycles) (Illumina). Adapter: TGGAATTCTCGGGTGCCAAGGAACTCCAGTCAC
DOI: 10.34740/kaggle/dsv/6614806
title: Global Crypto Currency Price Database
DOI: 10.4121/032e8e4c-29ad-47c7-9513-ccab784b2e17
title: Flood Fatalities database in western Algeria and Calabria (south Italy)

description: Flood mortality is still a serious concern in both developed and developing countries, requiring a deeper understanding to identify hazardous factors and mitigate the life losses. with this database, we compared the flood fatalities occurred in the period 1990-2022 in two Mediterranean regions characterized by different natural and anthropogenic frameworks and located in western Algeria and southern Italy, respectively. The main goal is to detect, either common features controlling flood mortality or typical factors causing local differences among the two areas, in order to identify the drivers of flood mortality and suggest how alleviate their impact applying mitigation strategies customized to the detected failures. With these purposes we created the database containing information 242 flood fatalities occurred in the two regions in the 33-year study period, including time and place of fatal accidents, age and gender of the victims, death circumstances and victim’s behavior.
DOI: 10.4121/032e8e4c-29ad-47c7-9513-ccab784b2e17.v1
title: Flood Fatalities database in western Algeria and Calabria (south Italy)

description: Flood mortality is still a serious concern in both developed and developing countries, requiring a deeper understanding to identify hazardous factors and mitigate the life losses. with this database, we compared the flood fatalities occurred in the period 1990-2022 in two Mediterranean regions characterized by different natural and anthropogenic frameworks and located in western Algeria and southern Italy, respectively. The main goal is to detect, either common features controlling flood mortality or typical factors causing local differences among the two areas, in order to identify the drivers of flood mortality and suggest how alleviate their impact applying mitigation strategies customized to the detected failures. With these purposes we created the database containing information 242 flood fatalities occurred in the two regions in the 33-year study period, including time and place of fatal accidents, age and gender of the victims, death circumstances and victim’s behavior.
DOI: 10.5281/zenodo.8409921
title: Dataset of emotional game experience (User Study)

description: Collected dataset :User study on setting requirments for emotional experienfce in a game under development by software engineer
DOI: 10.5281/zenodo.8409920
title: Dataset of emotional game experience (User Study)

description: Collected dataset :User study on setting requirments for emotional experienfce in a game under development by software engineer
DOI: 10.5281/zenodo.8335000
title: Sexual dimorphism in the proventriculus of the buff-tailed bumblebee Bombus terrestris (L. 1758) (Hymenoptera: Apidae)

description: This data set shows the measurements of the proventriculi from male and female <em>Bombus terrestris </em>individuals
DOI: 10.5281/zenodo.8334999
title: Sexual dimorphism in the proventriculus of the buff-tailed bumblebee Bombus terrestris (L. 1758) (Hymenoptera: Apidae)

description: This data set shows the measurements of the proventriculi from male and female <em>Bombus terrestris </em>individuals
DOI: 10.6084/m9.figshare.24203481
title: A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate

description: 1. Dimethoate is an organophosphate insecticide that is converted <i>in vivo</i> to omethoate, the active toxic moiety. Omethoate inhibits acetylcholinesterase (AChE) in the brain and red blood cells (RBCs). This paper describes the development of rat and human physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) models for dimethoate. 2. The model simulates the absorption and distribution of dimethoate and omethoate, the conversion of dimethoate to omethoate and to other metabolites, the metabolism and excretion of omethoate, and the inhibition of RBC and brain AChE. An extensive data collection program to estimate metabolism and inhibition parameters is described. 3. The suite of models includes an adult rat, post-natal rat, and human model. The rat models were evaluated by comparing model predictions of dimethoate and omethoate to measured blood time course data, and with RBC and brain AChE inhibition estimates from an extensive database of <i>in vivo</i> AChE measurements. 4. After the demonstration of adequately fitted rat models that were robust to sensitivity analysis, the human model was applied for estimation of points-of-departure (PODs) for risk assessment using the human-specific parameters in the human PBPK/PD model. Thus, the standard interspecies uncertainty factor can be reduced from 10X to 1X.
DOI: 10.6084/m9.figshare.24203481.v1
title: A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate

description: 1. Dimethoate is an organophosphate insecticide that is converted <i>in vivo</i> to omethoate, the active toxic moiety. Omethoate inhibits acetylcholinesterase (AChE) in the brain and red blood cells (RBCs). This paper describes the development of rat and human physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) models for dimethoate. 2. The model simulates the absorption and distribution of dimethoate and omethoate, the conversion of dimethoate to omethoate and to other metabolites, the metabolism and excretion of omethoate, and the inhibition of RBC and brain AChE. An extensive data collection program to estimate metabolism and inhibition parameters is described. 3. The suite of models includes an adult rat, post-natal rat, and human model. The rat models were evaluated by comparing model predictions of dimethoate and omethoate to measured blood time course data, and with RBC and brain AChE inhibition estimates from an extensive database of <i>in vivo</i> AChE measurements. 4. After the demonstration of adequately fitted rat models that were robust to sensitivity analysis, the human model was applied for estimation of points-of-departure (PODs) for risk assessment using the human-specific parameters in the human PBPK/PD model. Thus, the standard interspecies uncertainty factor can be reduced from 10X to 1X.
DOI: 10.6084/m9.figshare.24014945
title: The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants <i>in vitro</i>

description: 1. Temperature is considered to affect the activity of drug-metabolizing enzymes; however, no previous studies have compared temperature dependency among cytochrome P450 genetic variants. This study aimed to analyse warfarin 7-hydroxylation by CYP2C9 variants; omeprazole 5-hydroxylation by CYP2C19 variants; and midazolam 1-hydroxylation by CYP3A4 variants at 34 °C, 37 °C, and 40 °C. 2. Compared with that seen at 37 °C, the intrinsic clearance rates (<i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) of CYP2C9.1 and .2 were decreased (76 ∼ 82%), while that of CYP2C9.3 was unchanged at 34 °C. At 40 °C, CYP2C9.1, .2, and .3 exhibited increased (121%), unchanged and decreased (87%) intrinsic clearance rates, respectively. At 34 °C, the clearance rates of CYP2C19.1A and .10 were decreased (71 ∼ 86%), that of CYP2C19.1B was unchanged, and those of CYP2C19.8 and .23 were increased (130 ∼ 134%). At 40 °C, the clearance rates of CYP2C19.1A, .1B, .10, and .23 remained unaffected, while that of CYP2C19.8 was decreased (74%). At 34 °C, the clearance rates of CYP3A4.1 and .16 were decreased (79 ∼ 84%), those of CYP3A4.2 and .7 were unchanged, and that of CYP3A4.18 was slightly increased (112%). At 40 °C, the clearance rate of CYP3A4.1 remained unaffected, while those of CYP3A4.2, .7, .16, and .18 were decreased (58 ∼ 82%). 3. These findings may be clinically useful for dose optimisation in patients with hypothermia or hyperthermia.
DOI: 10.6084/m9.figshare.24014945.v1
title: The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants <i>in vitro</i>

description: 1. Temperature is considered to affect the activity of drug-metabolizing enzymes; however, no previous studies have compared temperature dependency among cytochrome P450 genetic variants. This study aimed to analyse warfarin 7-hydroxylation by CYP2C9 variants; omeprazole 5-hydroxylation by CYP2C19 variants; and midazolam 1-hydroxylation by CYP3A4 variants at 34 °C, 37 °C, and 40 °C. 2. Compared with that seen at 37 °C, the intrinsic clearance rates (<i>V</i><sub>max</sub>/<i>K</i><sub>m</sub>) of CYP2C9.1 and .2 were decreased (76 ∼ 82%), while that of CYP2C9.3 was unchanged at 34 °C. At 40 °C, CYP2C9.1, .2, and .3 exhibited increased (121%), unchanged and decreased (87%) intrinsic clearance rates, respectively. At 34 °C, the clearance rates of CYP2C19.1A and .10 were decreased (71 ∼ 86%), that of CYP2C19.1B was unchanged, and those of CYP2C19.8 and .23 were increased (130 ∼ 134%). At 40 °C, the clearance rates of CYP2C19.1A, .1B, .10, and .23 remained unaffected, while that of CYP2C19.8 was decreased (74%). At 34 °C, the clearance rates of CYP3A4.1 and .16 were decreased (79 ∼ 84%), those of CYP3A4.2 and .7 were unchanged, and that of CYP3A4.18 was slightly increased (112%). At 40 °C, the clearance rate of CYP3A4.1 remained unaffected, while those of CYP3A4.2, .7, .16, and .18 were decreased (58 ∼ 82%). 3. These findings may be clinically useful for dose optimisation in patients with hypothermia or hyperthermia.