cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.15468/dl.z4quak
title: Occurrence Download

description: A dataset containing 2654 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Carissa bispinosa (L.) Desf. ex Brenan"
 ]
}

 The dataset includes 2654 records from 79 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0087302-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.pwqkek
title: Occurrence Download

description: A dataset listing the 2013 species recorded in GBIF matching the query:
{
 "and" : [
 {
 "or" : [
 "Country is Colombia",
 "Country is Panama",
 "Country is Costa Rica",
 "Country is Honduras",
 "Country is Mexico",
 "Country is Nicaragua",
 "Country is Venezuela (Bolivarian Republic of)",
 "Country is Argentina",
 "Country is Ecuador"
 ]
 },
 "TaxonKey is Basiliscus basiliscus (Linnaeus, 1758)"
 ]
}

 The dataset's 2013 records were derived from 60 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018354-190415153152247/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.17605/osf.io/em5ac
title: Incorporation of complex narratives into dreaming
DOI: 10.6084/m9.figshare.30073450
title: Supplementary Material for: Circulating Tumor DNA Profiling Identifies Actionable Mutations as Prognostic Markers in Advanced Neuroendocrine Tumors

description: Introduction
Neuroendocrine tumors (NETs) are a rare and heterogeneous group of neoplasms with both clinical and genetic diversity. The clinical applicability of molecular profiling using liquid biopsy for identifying actionable drug targets and prognostic indicators in patients with advanced NETs remains unclear.
Methods
In this study, we utilized a custom-made 37 genes panel of circulating tumor DNA (ctDNA) based on next-generation sequencing (NGS) in 47 patients with advanced NETs. 
Results
A total of 223 non-synonymous mutations were identified, with the highest frequencies found in TSC2, JAG2, NOTCH3, KMT2C, and SETD2. NETs originating from the stomach exhibited the highest average mutation frequency, while paragangliomas had the lowest. TERT mutations were associated with significantly higher hazard ratios for both progression-free survival (PFS) and overall survival (OS). Higher blood tumor mutational burden (bTMB) was linked to poor prognosis in Octreotide LAR-treated patients and correlated with higher Ki-67 levels, and alterations in the TM, mTOR, and Notch pathways. Treatment responders had higher bTMB, chromatin remodeling signaling mutation burden, and maximum somatic allele frequency (MSAF). Patients with high MSAF demonstrated better PFS, whereas those with low MSAF had better OS. A strong positive correlation was observed between MSAF levels and mutational burden. Co-occurring mutations in the TM, mTOR, and NOTCH pathways suggested future therapeutic strategies.
Conclusions
We constructed an overview of mutations in 37 genes, linking ctDNA to survival in advanced NETs. TERT mutations, bTMB, and MSAF predict PFS or OS. Co-occurring TM, mTOR, and NOTCH pathway alterations highlight ctDNA's potential in guiding precision medicine.
DOI: 10.6084/m9.figshare.30073450.v1
title: Supplementary Material for: Circulating Tumor DNA Profiling Identifies Actionable Mutations as Prognostic Markers in Advanced Neuroendocrine Tumors

description: Introduction
Neuroendocrine tumors (NETs) are a rare and heterogeneous group of neoplasms with both clinical and genetic diversity. The clinical applicability of molecular profiling using liquid biopsy for identifying actionable drug targets and prognostic indicators in patients with advanced NETs remains unclear.
Methods
In this study, we utilized a custom-made 37 genes panel of circulating tumor DNA (ctDNA) based on next-generation sequencing (NGS) in 47 patients with advanced NETs. 
Results
A total of 223 non-synonymous mutations were identified, with the highest frequencies found in TSC2, JAG2, NOTCH3, KMT2C, and SETD2. NETs originating from the stomach exhibited the highest average mutation frequency, while paragangliomas had the lowest. TERT mutations were associated with significantly higher hazard ratios for both progression-free survival (PFS) and overall survival (OS). Higher blood tumor mutational burden (bTMB) was linked to poor prognosis in Octreotide LAR-treated patients and correlated with higher Ki-67 levels, and alterations in the TM, mTOR, and Notch pathways. Treatment responders had higher bTMB, chromatin remodeling signaling mutation burden, and maximum somatic allele frequency (MSAF). Patients with high MSAF demonstrated better PFS, whereas those with low MSAF had better OS. A strong positive correlation was observed between MSAF levels and mutational burden. Co-occurring mutations in the TM, mTOR, and NOTCH pathways suggested future therapeutic strategies.
Conclusions
We constructed an overview of mutations in 37 genes, linking ctDNA to survival in advanced NETs. TERT mutations, bTMB, and MSAF predict PFS or OS. Co-occurring TM, mTOR, and NOTCH pathway alterations highlight ctDNA's potential in guiding precision medicine.
DOI: 10.6084/m9.figshare.30073453
title: Supplementary Material for: Expanded Targeted-Exome Sequencing and Functional Validation Improve Molecular Diagnosis and Refine Genotype-Phenotype Correlations in Congenital Hypogonadotropic Hypogonadism

description: Introduction: Congenital Hypogonadotropic Hypogonadism (CHH) arises from defects in the synthesis, secretion, or action of gonadotropin-releasing hormone (GnRH), resulting in incomplete or absent pubertal development and various non-reproductive features. CHH is genetically heterogeneous, with over 50 genes implicated in its pathogenesis. This study aimed to elucidate the genetic variants of CHH in a cohort of patients from a single-center endocrinology unit. 
Methods:We used a targeted next-generation sequencing panel to analyze 52 CHH-related genes in 35 patients. Functional studies validated two of the identified variants.
Results: Molecular etiology was identified in 20 of 35 patients (57%). Among these, 12 (39%) had variants in multiple CHH-related genes, with oligogenic inheritance confirmed in two cases. Novel pathogenic variants (both SNVs and CNVs) were identified, including ANOS1 p.Gln238* and c.318+2T&gt;C, CHD7 p.Ser734Ilefs5 and p.Gln592Serfs16, FGFR1 p.Ala36Profs67, c.1663+5G&gt;A, and p.Tyr210*, DMXL2 deletion (83.1 Kb), and SOX2 deletion (1.1 Mb). In total, 21 pathogenic or likely pathogenic variants across 15 CHH-related genes were detected, including ANOS1, CHD7, FGFR1, PROKR2, and others. A functional study confirmed the loss of function in the KISS1R p.Ala203Asp variant.
Conclusion: Our findings demonstrate the utility of a NGS panel in diagnosing genetically complex conditions like CHH and underscore the role of oligogenic inheritance in its phenotypic diversity. The inclusion of genes previously associated with syndromic CHH forms such as CHARGE in the exome panel may highlight possible shared mechanisms with neurodevelopmental disorders, aiding early diagnosis, genetic counseling, and treatment.
DOI: 10.6084/m9.figshare.30073453.v1
title: Supplementary Material for: Expanded Targeted-Exome Sequencing and Functional Validation Improve Molecular Diagnosis and Refine Genotype-Phenotype Correlations in Congenital Hypogonadotropic Hypogonadism

description: Introduction: Congenital Hypogonadotropic Hypogonadism (CHH) arises from defects in the synthesis, secretion, or action of gonadotropin-releasing hormone (GnRH), resulting in incomplete or absent pubertal development and various non-reproductive features. CHH is genetically heterogeneous, with over 50 genes implicated in its pathogenesis. This study aimed to elucidate the genetic variants of CHH in a cohort of patients from a single-center endocrinology unit. 
Methods:We used a targeted next-generation sequencing panel to analyze 52 CHH-related genes in 35 patients. Functional studies validated two of the identified variants.
Results: Molecular etiology was identified in 20 of 35 patients (57%). Among these, 12 (39%) had variants in multiple CHH-related genes, with oligogenic inheritance confirmed in two cases. Novel pathogenic variants (both SNVs and CNVs) were identified, including ANOS1 p.Gln238* and c.318+2T&gt;C, CHD7 p.Ser734Ilefs5 and p.Gln592Serfs16, FGFR1 p.Ala36Profs67, c.1663+5G&gt;A, and p.Tyr210*, DMXL2 deletion (83.1 Kb), and SOX2 deletion (1.1 Mb). In total, 21 pathogenic or likely pathogenic variants across 15 CHH-related genes were detected, including ANOS1, CHD7, FGFR1, PROKR2, and others. A functional study confirmed the loss of function in the KISS1R p.Ala203Asp variant.
Conclusion: Our findings demonstrate the utility of a NGS panel in diagnosing genetically complex conditions like CHH and underscore the role of oligogenic inheritance in its phenotypic diversity. The inclusion of genes previously associated with syndromic CHH forms such as CHARGE in the exome panel may highlight possible shared mechanisms with neurodevelopmental disorders, aiding early diagnosis, genetic counseling, and treatment.
DOI: 10.6084/m9.figshare.30073456
title: Supplementary Material for: A Rare Case of Lymphoepithelioma-like Carcinoma of the Skin on the Chest: A Case Report

description: Introduction: We present a case of lymphoepithelioma-like carcinoma of the skin (LELCS) of the chest identified in an elderly white male. We discuss the management and various treatment options for this rare type of cutaneous malignancy and highlight treatment uncertainty for this uncommon skin cancer, and the need to balance the best patient outcomes with minimal treatment morbidity.
Case Presentation: Our patient presented with a waxing and waning erythematous rash on his chest for two years. After a shave biopsy revealed lymphoepithelioma-like carcinoma, the patient underwent wide local excision and six weeks of radiation therapy due to the identification of adverse pathologic features. 
Conclusion: Overall, this case shows the diverse range of LELCS presentations and available treatment options and highlights areas of clinical treatment uncertainty and areas for future therapeutic development.
DOI: 10.6084/m9.figshare.30073456.v1
title: Supplementary Material for: A Rare Case of Lymphoepithelioma-like Carcinoma of the Skin on the Chest: A Case Report

description: Introduction: We present a case of lymphoepithelioma-like carcinoma of the skin (LELCS) of the chest identified in an elderly white male. We discuss the management and various treatment options for this rare type of cutaneous malignancy and highlight treatment uncertainty for this uncommon skin cancer, and the need to balance the best patient outcomes with minimal treatment morbidity.
Case Presentation: Our patient presented with a waxing and waning erythematous rash on his chest for two years. After a shave biopsy revealed lymphoepithelioma-like carcinoma, the patient underwent wide local excision and six weeks of radiation therapy due to the identification of adverse pathologic features. 
Conclusion: Overall, this case shows the diverse range of LELCS presentations and available treatment options and highlights areas of clinical treatment uncertainty and areas for future therapeutic development.
DOI: 10.15468/dl.at25bn
title: Occurrence Download

description: A dataset containing 1223 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Falco alopex (Heuglin, 1861)"
 ]
}

 The dataset includes 1223 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0372425-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5asc5f
title: Occurrence Download

description: A dataset containing 5 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Saussurea hultenii Lipsch."
 ]
}

 The dataset includes 5 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0114944-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.2b8ja8
title: Occurrence Download

description: A dataset containing 7761 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Linum alpinum Jacq., Linum perenne L., Linum striatum Walter)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 7761 records from 141 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0244542-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.bcj6p3
title: Occurrence Download

description: A dataset containing 27 species occurrences available in GBIF matching the query:
{
 "and" : [
 "Country is China",
 "TaxonKey is Soliva anthemifolia R.Br."
 ]
}

 The dataset includes 27 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0131853-230530130749713/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.jze42y
title: Occurrence Download

description: A dataset containing 7 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Calamus boniensis Becc. ex K.Heyne"
 ]
}

 The dataset includes 7 records from 2 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0078339-240229165702484/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.y79zw7
title: Occurrence Download

description: A dataset containing 10828 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Falco chicquera Daudin, 1800"
 ]
}

 The dataset includes 10828 records from 68 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0372430-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ut348h
title: Occurrence Download

description: A dataset containing 46 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Taraxacum luridum G.E.Haglund"
 ]
}

 The dataset includes 46 records from 18 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005443-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.em2z28
title: Occurrence Download

description: A dataset containing 486 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Myrina silenus (Fabricius, 1775)"
 ]
}

 The dataset includes 486 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0184836-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.k6bjxj
title: Occurrence Download

description: A dataset containing 19885 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Esacus magnirostris (Vieillot, 1818)"
 ]
}

 The dataset includes 19885 records from 75 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0387989-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.uhuh9x
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Taraxacum bachczisaraicum Tzvelev"
 ]
}

 The dataset includes 4 records from 1 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005440-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.3tt738
title: Occurrence Download

description: A dataset containing 5150 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Culcita macrocarpa C.Presl"
 ]
}

 The dataset includes 5150 records from 82 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0174792-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ap9eg4
title: Occurrence Download

description: A dataset containing 3614 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Lobelia angulata G.Forst.",
 "HasCoordinate is true"
 ]
}

 The dataset includes 3614 records from 44 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066792-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.wtexpb
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Taraxacum badiocinnamomeum Kirschner & Stepánek"
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005445-230810091245214/datasets/export for details.
DOI: 10.15468/dl.4qtj8y
title: Occurrence Download

description: A dataset containing 65 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Aethionema schistosum Boiss. & Kotschy"
 ]
}

 The dataset includes 65 records from 16 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0038229-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.t2g6w5
title: Occurrence Download

description: A dataset containing 5679 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Champia parvula (C.Agardh) Harv."
 ]
}

 The dataset includes 5679 records from 176 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0005447-230810091245214/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.5w3rfs
title: Occurrence Download

description: A dataset containing 4 species occurrences available in GBIF matching the query:
{
 "TaxonKey" : [
 "is Anatolanthias apiomycter Anderson, Parin & Randall, 1990"
 ]
}

 The dataset includes 4 records from 4 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0066802-220831081235567/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.mspp9c
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Sphaeropsis glandulosa Cooke",
 {
 "not" : {
 "DatasetKey" : [
 "is Global database of alien macrofungi"
 ]
 }
 },
 {
 "or" : [
 "Country is Poland",
 "Country is Poland"
 ]
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0395223-210914110416597/datasets/export for details.
DOI: 10.15468/dl.vv7kue
title: Occurrence Download

description: A dataset containing 0 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is Acaudaleyrodes rachipora (Singh, 1931)",
 {
 "or" : [
 "Country is United States of America",
 "Country is United States",
 "Country is United States of America",
 "Country is Canada",
 "Continent is North America"
 ]
 }
 ]
}

 The dataset includes 0 records from 0 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0132076-210914110416597/datasets/export for details.
DOI: 10.15468/dl.94ab9z
title: Occurrence Download

description: A dataset containing 51403 species occurrences available in GBIF matching the query:
{
 "and" : [
 "TaxonKey is one of (Lindtneria trachyspora (Bourdot & Galzin) Pilát, Linnaea borealis L.)",
 "Geometry POLYGON((-9.36035 44.71551,-10.59082 42.81152,-11.82129 36.80928,-7.69043 36.17336,-3.38379 35.88905,3.12012 38.13456,9.18457 38.20366,11.7334 37.16032,12.78809 34.74161,17.09473 33.79741, 23.15918 34.23451,30.10254 32.62087,33.2666 32.99024,35.72754 35.03,33.00293 35.53223,28.69629 35.17381,28.34473 36.31513,25.7959 37.50973,24.91699 39.90974,28.78418 40.6473,30.71777 41.17865,36.87012 45.213,38.18848 46.98025,38.71582 47.7541,39.94629 47.93107,40.20996 49.61071,37.0459 50.34546,35.72754 50.40152,33.79395 52.26816,31.68457 51.94426,31.4209 53.27835,32.56348 53.43572,30.98145 54.77535,30.89355 55.52863,28.43262 56.02295,27.20215 57.65716,27.37793 58.30949,27.90527 59.17593,29.66309 59.88894,27.6416 60.58697,31.50879 62.75473,28.78418 69.83962,30.89355 70.28912,29.22363 71.55274,21.75293 71.30079,14.28223 70.14036,11.38184 67.47492,4.87793 63.66576,-5.53711 71.52491,-10.63477 71.69129,-21.5332 67.74276,-28.56445 65.36684,-24.3457 61.35461,-9.36035 44.71551))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false",
 "Year is greater than or equal to 1980",
 "Year is less than or equal to 2021"
 ]
}

 The dataset includes 51403 records from 125 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0244540-210914110416597/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.
DOI: 10.15468/dl.ar59cg
title: Occurrence Download

description: A dataset containing 19923 species occurrences available in GBIF matching the query:
{
 "and" : [
 "DatasetKey is one of (EOD – eBird Observation Dataset, iNaturalist Research-grade Observations, Registros de aves del Valle de Aburrá asociados al estudio del análisis de la conectividad ecológica funcional y estructural en el Área Metropolitana del Valle de Aburrá, Tropicos MO Specimen Data, Biodiversidad asociada al proyecto Expansión y Confiabilidad Subestación Caldas 110 kV, Museo Entomológico Francisco Luis Gallego UNAL-MED, ICN - Universidad Nacional de Colombia)",
 "Geometry POLYGON((-75.57397 6.13268,-75.58287 6.11871,-75.59834 6.11079,-75.61521 6.11265,-75.63067 6.11498,-75.6391 6.09401,-75.63114 6.06559,-75.57397 6.04602,-75.54726 6.04882,-75.53274 6.07631,-75.52899 6.09728,-75.53274 6.10939,-75.5482 6.13408,-75.57397 6.13268))",
 "HasCoordinate is true",
 "HasGeospatialIssue is false"
 ]
}

 The dataset includes 19923 records from 7 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0091009-230224095556074/datasets/export for details.
 
Data from some individual datasets included in this download may be licensed under less restrictive terms.