cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.6084/m9.figshare.24901584
title: <b>Frontal midline theta transcranial alternating current stimulation </b><b>enhances early consolidation of episodic memory</b>

description: Evidence implicating theta rhythms in declarative memory encoding and retrieval, together with the notion that both retrieval and consolidation involve memory reinstatement or replay, suggests that post-learning theta rhythm modulation can promote early consolidation of newly formed memories. Building on earlier work employing theta neurofeedback, we examined whether theta-frequency transcranial alternating stimulation (tACS) can engender effective consolidation of newly formed episodic memories, compared with beta frequency stimulation or sham control conditions. We compared midline frontal and posterior parietal theta stimulation montages, and examined whether benefits to memory of theta upregulation are attributable to consolidation rather than to retrieval processes by using a washout period to eliminate tACS after-effects between stimulation and memory assessment. Four groups of participants viewed object pictures followed by a free recall test during three study-test cycles. They then engaged in tACS (frontal theta montage / parietal theta montage / frontal beta montage / sham) for a period of 20 minutes, followed by a 2-hour break. Free recall assessments were conducted after the break, 24 hours later, and 7 days later. Frontal midline theta-tACS induced significant off-line retrieval gains at all assessment time points, relative to all other conditions. This indicates that theta upregulation provides optimal conditions for consolidation of episodic memory, independent of mental-state strategies.
DOI: 10.6084/m9.figshare.24901584.v6
title: <b>Frontal midline theta transcranial alternating current stimulation </b><b>enhances early consolidation of episodic memory</b>

description: Evidence implicating theta rhythms in declarative memory encoding and retrieval, together with the notion that both retrieval and consolidation involve memory reinstatement or replay, suggests that post-learning theta rhythm modulation can promote early consolidation of newly formed memories. Building on earlier work employing theta neurofeedback, we examined whether theta-frequency transcranial alternating stimulation (tACS) can engender effective consolidation of newly formed episodic memories, compared with beta frequency stimulation or sham control conditions. We compared midline frontal and posterior parietal theta stimulation montages, and examined whether benefits to memory of theta upregulation are attributable to consolidation rather than to retrieval processes by using a washout period to eliminate tACS after-effects between stimulation and memory assessment. Four groups of participants viewed object pictures followed by a free recall test during three study-test cycles. They then engaged in tACS (frontal theta montage / parietal theta montage / frontal beta montage / sham) for a period of 20 minutes, followed by a 2-hour break. Free recall assessments were conducted after the break, 24 hours later, and 7 days later. Frontal midline theta-tACS induced significant off-line retrieval gains at all assessment time points, relative to all other conditions. This indicates that theta upregulation provides optimal conditions for consolidation of episodic memory, independent of mental-state strategies.
DOI: 10.6084/m9.figshare.24897266
title: A Unified Nonparametric Fiducial Approach to Interval-Censored Data

description: Censored data, where the event time is partially observed, are challenging for survival probability estimation. In this article, we introduce a novel nonparametric fiducial approach to interval-censored data, including right-censored, current status, case II censored, and mixed case censored data. The proposed approach leveraging a simple Gibbs sampler has a useful property of being “one size fits all,” that is, the proposed approach automatically adapts to all types of noninformative censoring mechanisms. As shown in the extensive simulations, the proposed fiducial confidence intervals significantly outperform existing methods in terms of both coverage and length. In addition, the proposed fiducial point estimator has much smaller estimation errors than the nonparametric maximum likelihood estimator. Furthermore, we apply the proposed method to Austrian rubella data and a study of hemophiliacs infected with the human immunodeficiency virus. The strength of the proposed fiducial approach is not only estimation and uncertainty quantification but also its automatic adaptation to a variety of censoring mechanisms. Supplementary materials for this article are available online.
DOI: 10.6084/m9.figshare.24897266.v1
title: A Unified Nonparametric Fiducial Approach to Interval-Censored Data

description: Censored data, where the event time is partially observed, are challenging for survival probability estimation. In this article, we introduce a novel nonparametric fiducial approach to interval-censored data, including right-censored, current status, case II censored, and mixed case censored data. The proposed approach leveraging a simple Gibbs sampler has a useful property of being “one size fits all,” that is, the proposed approach automatically adapts to all types of noninformative censoring mechanisms. As shown in the extensive simulations, the proposed fiducial confidence intervals significantly outperform existing methods in terms of both coverage and length. In addition, the proposed fiducial point estimator has much smaller estimation errors than the nonparametric maximum likelihood estimator. Furthermore, we apply the proposed method to Austrian rubella data and a study of hemophiliacs infected with the human immunodeficiency virus. The strength of the proposed fiducial approach is not only estimation and uncertainty quantification but also its automatic adaptation to a variety of censoring mechanisms. Supplementary materials for this article are available online.
DOI: 10.5281/zenodo.10610789
title: aquilaria_malaccensis_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.10610790
title: aquilaria_malaccensis_spades_01.fasta.gz

description: .
DOI: 10.5281/zenodo.10610770
title: Late Ordovician (440 Ma; Hirnantian) climatic simulation conducted using the general circulation model FOAM.

description: Climatic simulation conducted using the general circulation model FOAM for the Late Ordovician (440 Ma; Hirnantian); using the same model setup as [10.1038/s41467-023-41685-w], notably the continental reconstructions of [10.1016/j.epsl.2022.117717].
DOI: 10.5281/zenodo.10610771
title: Late Ordovician (440 Ma; Hirnantian) climatic simulation conducted using the general circulation model FOAM.

description: Climatic simulation conducted using the general circulation model FOAM for the Late Ordovician (440 Ma; Hirnantian); using the same model setup as [10.1038/s41467-023-41685-w], notably the continental reconstructions of [10.1016/j.epsl.2022.117717].
DOI: 10.17615/aa24-fd93
title: Animal CL1

description: Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.  
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes in BAT vasculature during adrenergic stimulation of non-shivering thermogenesis by norepinephrine, a vasoconstrictor known to mediate brown fat heat production, and by CL 316 243, a specific β3-adrenergic agonist also known to elicit BAT thermogenesis in rodents.
We found that while CL 316 243 causes local vasodilation in BAT, with little impact on the rest of the vasculature throughout the body, norepinephrine leads to local vasodilation in addition to peripheral vasoconstriction. As a result, a significantly greater relative increase in BAT perfusion is observed following the injection of NE compared to CL. 
This study demonstrates the use of in vivo CT angiography as an effective tool in assessing vascular reactivity in BAT both qualitatively and quantitatively in preclinical studies.
DOI: 10.17615/ybd7-ps80
title: Animal CL2

description: Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.  
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes in BAT vasculature during adrenergic stimulation of non-shivering thermogenesis by norepinephrine, a vasoconstrictor known to mediate brown fat heat production, and by CL 316 243, a specific β3-adrenergic agonist also known to elicit BAT thermogenesis in rodents.
We found that while CL 316 243 causes local vasodilation in BAT, with little impact on the rest of the vasculature throughout the body, norepinephrine leads to local vasodilation in addition to peripheral vasoconstriction. As a result, a significantly greater relative increase in BAT perfusion is observed following the injection of NE compared to CL. 
This study demonstrates the use of in vivo CT angiography as an effective tool in assessing vascular reactivity in BAT both qualitatively and quantitatively in preclinical studies.
DOI: 10.17615/4j0j-0p17
title: Animal CL3

description: Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.  
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes in BAT vasculature during adrenergic stimulation of non-shivering thermogenesis by norepinephrine, a vasoconstrictor known to mediate brown fat heat production, and by CL 316 243, a specific β3-adrenergic agonist also known to elicit BAT thermogenesis in rodents.
We found that while CL 316 243 causes local vasodilation in BAT, with little impact on the rest of the vasculature throughout the body, norepinephrine leads to local vasodilation in addition to peripheral vasoconstriction. As a result, a significantly greater relative increase in BAT perfusion is observed following the injection of NE compared to CL. 
This study demonstrates the use of in vivo CT angiography as an effective tool in assessing vascular reactivity in BAT both qualitatively and quantitatively in preclinical studies.
DOI: 10.17615/0k95-3793
title: Animal NE1

description: Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.  
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes in BAT vasculature during adrenergic stimulation of non-shivering thermogenesis by norepinephrine, a vasoconstrictor known to mediate brown fat heat production, and by CL 316 243, a specific β3-adrenergic agonist also known to elicit BAT thermogenesis in rodents.
We found that while CL 316 243 causes local vasodilation in BAT, with little impact on the rest of the vasculature throughout the body, norepinephrine leads to local vasodilation in addition to peripheral vasoconstriction. As a result, a significantly greater relative increase in BAT perfusion is observed following the injection of NE compared to CL. 
This study demonstrates the use of in vivo CT angiography as an effective tool in assessing vascular reactivity in BAT both qualitatively and quantitatively in preclinical studies.
DOI: 10.17615/a7yr-5k40
title: Animal NE2

description: Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.  
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes in BAT vasculature during adrenergic stimulation of non-shivering thermogenesis by norepinephrine, a vasoconstrictor known to mediate brown fat heat production, and by CL 316 243, a specific β3-adrenergic agonist also known to elicit BAT thermogenesis in rodents.
We found that while CL 316 243 causes local vasodilation in BAT, with little impact on the rest of the vasculature throughout the body, norepinephrine leads to local vasodilation in addition to peripheral vasoconstriction. As a result, a significantly greater relative increase in BAT perfusion is observed following the injection of NE compared to CL. 
This study demonstrates the use of in vivo CT angiography as an effective tool in assessing vascular reactivity in BAT both qualitatively and quantitatively in preclinical studies.
DOI: 10.17615/14be-4t30
title: Animal NE3

description: Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.  
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes in BAT vasculature during adrenergic stimulation of non-shivering thermogenesis by norepinephrine, a vasoconstrictor known to mediate brown fat heat production, and by CL 316 243, a specific β3-adrenergic agonist also known to elicit BAT thermogenesis in rodents.
We found that while CL 316 243 causes local vasodilation in BAT, with little impact on the rest of the vasculature throughout the body, norepinephrine leads to local vasodilation in addition to peripheral vasoconstriction. As a result, a significantly greater relative increase in BAT perfusion is observed following the injection of NE compared to CL. 
This study demonstrates the use of in vivo CT angiography as an effective tool in assessing vascular reactivity in BAT both qualitatively and quantitatively in preclinical studies.
DOI: 10.17615/4jht-3b63
title: Low knowledge about hepatitis B prevention among pregnant women in Kinshasa, Democratic Republic of Congo

description: Infants infected perinatally with hepatitis B (HBV) are at the highest risk of developing chronic hepatitis and associated sequelae. Prevention of mother-to-child transmission (PMTCT) of HBV requires improved screening and awareness of the disease. This study evaluated existing HBV knowledge among pregnant mothers (n = 280) enrolled in two HBV studies in urban maternity centers in Kinshasa, Democratic Republic of the Congo. All mothers responded to three knowledge questions upon study enrollment. Baseline levels of knowledge related to HBV transmission, treatment, prevention, and symptoms were low across all participants: 68.8% did not know how HBV was transmitted, 70.7% did not know how to prevent or treat HBV MTCT, and 79.6% did not know signs and symptoms of HBV. Over half of participants responded “I don’t know” to all questions. HBV-positive women who participated in both studies (n= 46) were asked the same questions during both studies and showed improved knowledge after screening and treatment, despite no formal educational component in either study (p < 0.001). These findings highlight the need for intensified education initiatives in highly endemic areas to improve PMTCT efforts.
DOI: 10.5281/zenodo.7953509
title: The CodeSparks Framework - Augmenting Source Code with Glyph-based Visualizations

description: Supplemental material to: The CodeSparks Framework - Augmenting Source Code with Glyph-based Visualizations<br> Revision: Replaced the survey (quantitative) with focus group interviews (qualitative).
DOI: 10.5281/zenodo.10473079
title: In-Situ Thread Visualization - Programming Framework, Visual Design, and Empirical Studies

description: Supplementary material to the dissertation entitled: In-Situ Thread Visualization - Programming Framework, Visual Design, and Empirical Studies
DOI: 10.5281/zenodo.10473080
title: In-Situ Thread Visualization - Programming Framework, Visual Design, and Empirical Studies

description: Supplementary material to the dissertation entitled: In-Situ Thread Visualization - Programming Framework, Visual Design, and Empirical Studies
DOI: 10.6084/m9.figshare.25134614
title: <b>The wake of a large wind turbine in stable atmospheric boundary layer flow, simulated in the EnFlo stratified-flow wind tunnel</b>

description: The EnFlo stratified-flow wind tunnel is described, and the parametrization of stable atmospheric boundary layers in the context of wind turbines and stability classification is given, as are the scaling constraints for stratified-flow wind-tunnel experiments. Wake measurements of mean velocity, Reynolds stresses and turbulent heat flux were made for three mild stable states including overlying inversion, and the neutral state. The depth of the atmospheric boundary layer was kept constant, and so the results show the effect of change of stability alone, without the change of scale that would also arise in full scale measurements, an advantage provided by wind tunnel experiments. The simulated boundary-layer wind-speed profile is the same in each case, its height slightly exceeding the blade-tip top height, and the velocity deficit at the turbine is also the same in each, implying a constant thrust coefficient. In the near wake the momentum deficit rises more rapidly in the stable cases, and stays higher further downstream where it is subsequently reduced by turbulent mixing. The wake grows less rapidly in the vertical direction in the stable cases, both above and below hub height, the height above growing still less rapidly with in imposed inversion, while the height below is unaffected by the inversion. The wake width is largely unaffected by stability. Stability reduces the Reynolds stresses in the wake over and above the reduction in the undisturbed flow; there is not a simple superposition. In the lower part of the wake the stresses are not affected by the inversion, while they are in the upper part. Turbulent heat flux is increased in the bulk of the wake, more so with an inversion, but is reduced to the surface and unaffected by an inversion. The paper that this data set relates to was submitted to Journal of Renewable and Sustainable Energy, 2023.
DOI: 10.6084/m9.figshare.25134614.v1
title: <b>The wake of a large wind turbine in stable atmospheric boundary layer flow, simulated in the EnFlo stratified-flow wind tunnel</b>

description: The EnFlo stratified-flow wind tunnel is described, and the parametrization of stable atmospheric boundary layers in the context of wind turbines and stability classification is given, as are the scaling constraints for stratified-flow wind-tunnel experiments. Wake measurements of mean velocity, Reynolds stresses and turbulent heat flux were made for three mild stable states including overlying inversion, and the neutral state. The depth of the atmospheric boundary layer was kept constant, and so the results show the effect of change of stability alone, without the change of scale that would also arise in full scale measurements, an advantage provided by wind tunnel experiments. The simulated boundary-layer wind-speed profile is the same in each case, its height slightly exceeding the blade-tip top height, and the velocity deficit at the turbine is also the same in each, implying a constant thrust coefficient. In the near wake the momentum deficit rises more rapidly in the stable cases, and stays higher further downstream where it is subsequently reduced by turbulent mixing. The wake grows less rapidly in the vertical direction in the stable cases, both above and below hub height, the height above growing still less rapidly with in imposed inversion, while the height below is unaffected by the inversion. The wake width is largely unaffected by stability. Stability reduces the Reynolds stresses in the wake over and above the reduction in the undisturbed flow; there is not a simple superposition. In the lower part of the wake the stresses are not affected by the inversion, while they are in the upper part. Turbulent heat flux is increased in the bulk of the wake, more so with an inversion, but is reduced to the surface and unaffected by an inversion. The paper that this data set relates to was submitted to Journal of Renewable and Sustainable Energy, 2023.
DOI: 10.5281/zenodo.10610871
title: Dataset related to article: Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples

description: The database contains raw data from each validation experiment for the lc-ms/ms quantification method of levodopa, levodopa methyl-ester (melevodopa) and carbidopa in human plasma. Preliminar data regarding benserazide are also shown, but they were not included in the publication due to low reproducibility. the method was also applied to an anonymized patient, which was administered different levodopa formulations.
DOI: 10.5281/zenodo.10610872
title: Dataset related to article: Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples

description: The database contains raw data from each validation experiment for the lc-ms/ms quantification method of levodopa, levodopa methyl-ester (melevodopa) and carbidopa in human plasma. Preliminar data regarding benserazide are also shown, but they were not included in the publication due to low reproducibility. the method was also applied to an anonymized patient, which was administered different levodopa formulations.