cometadata/datacite-titles-descriptions-related-identifiers huggingface dataset:
DOI: 10.21430/m39seum79k
title: Asthma Phenotypes in the Inner City (APIC/ICAC-19)

description: This study looks to define the phenotypic characteristics of Difficult-to-Treat asthma, among 650 children between the ages of 6 to 17 years, receiving one year of guidelines-based therapy for asthma and rhinitis/rhinosinusitis.
DOI: 10.21430/m39tacciaj
title: MS3 peptide detection

description: MS3 peptide detection
DOI: 10.21430/m3a6gyd5l0
title: Immunologic and genomic signatures of influenza vaccine response - 2014

description: Project 1: Immunologic and genomic signatures of influenza vaccine response - year5 2014
DOI: 10.21430/m3ac1wmbdo
title: DC transcriptomics in response to vaccines

description: We measured the transcriptional responses of four human APC subsets to microbial vaccine challenge in vitro. We identified common and specific signatures, highlighting subset-specific responses to vaccines.
DOI: 10.21430/m3afz310ee
title: ADRN Influenza Vaccine Pilot (ADRN-03)

description: A new flu vaccine which is injected into the skin instead of into the muscle has recently been approved by the Food and Drug Administration for vaccination of the general population including patients with atopic dermatitis (AD). This new vaccine has been shown to work as well as the vaccine which is injected into muscle when tested in people without atopic dermatitis. The primary endpoint of the study is to estimate the variance of the log fold change from baseline in HAI antibody titers for non-atopic controls and participants with atopic dermatitis without a history of eczema herpeticum (ADEH-), following administration of a single dose of the seasonal 2011-2012 Fluzone Intradermal vaccine.
DOI: 10.21430/m3ag2c6125
title: Observational Study of Alloimmunity in Cardiac Transplant Recipients (CTOT-05)

description: The purpose of this study is to identify a single test or a combination of noninvasive tests currently used for heart transplant monitoring that correlate to long-term graft survival.
DOI: 10.21430/m3am8g2i2q
title: Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth

description: This study investigated the association between maternal height and fetal growth measurement
DOI: 10.21430/m3apbca91h
title: A Study To Test An Anti-Rejection Therapy After Kidney Transplantation (IN01/OLN-359)

description: Kidney transplantation is often successful. However, despite aggressive anti-rejection drug therapy, some patients will reject their new kidney. This study is designed to test two anti-rejection approaches. Two medications in this study are currently used in children, but there is no information regarding which drug is safer or more effective. Survival rates in renal transplantation are unacceptably low. Therefore, there is a need for an improved post-transplant treatment, such as the induction therapy used in this study.
DOI: 10.21430/m3az2nq0xp
title: RNAseq of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for NF1 Glioma Growth

description: The molecular mechanism of microglial associated optic glioma is still unknown. To identify potential tumor-associated microglial factors, global RNAseq gene expression experiment was conducted in the mouse glioma models. After validating of prioritized potential secreted or membrane-bound proteins, chemokine (C-C motif) ligand 5 (Ccl5) was identified as a chemokine highly expressed in genetically engineered Nf1 mouse optic gliomas relative to nonneoplastic optic nerves. Some positive effects of targeted Ccl5 in vito and vivo experiments establish Ccl5 as a relevant stroma-targeted low-grade brain tumor treatment marker
DOI: 10.21430/m3bk0ytx2j
title: GPAC ITN025AD: Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children

description: The purpose of this study is to determine whether early childhood exposure to common allergens (substances that can trigger allergies and asthma) can prevent the development of asthma in children at high risk for developing the disease.
DOI: 10.21430/m3c546vf92
title: Project 3 - Optimization experiments DCs DV2 and DV4 - MBAA

description: Ex vivo infections of DCs DENV2 and DENV4 - MBAA
DOI: 10.21430/m3crd72e92
title: IL2-RAPA ITN018AI: Proleukin and Rapamune in Type 1 Diabetes Mellitus

description: This study will evaluate whether treatment of type 1 diabetes patients with Proleukin and Rapamune can halt the destruction of beta cells.
DOI: 10.21430/m3cs60jpjj
title: STAyCIS ITN020AI: Atorvastatin (Lipitor) Therapy in Patients with Clinically Isolated Syndrome (CIS) at Risk for Multiple Sclerosis

description: Patients who have been diagnosed with clinically isolated syndrome (CIS) often develop problems related to the central nervous system, which controls the nerves in the body. Some of these patients may later be diagnosed with multiple sclerosis (MS), a progressive disease of the nervous system. The purpose of this study is to determine if the drug atorvastatin is helpful to CIS patients. Study hypothesis: Early intervention with atorvastatin in patients with CIS will result in a state of immunological tolerance.
DOI: 10.21430/m3d02nosvh
title: Human Immune Signature of Mycobacterium Tuberculosis infection. (See SDY1324 for sorted cell gene expression data)

description: T cell immune signature associated with latent TB infection as well as BCG vaccination was studied
DOI: 10.21430/m3d491lgdt
title: Exploring the human maternal microbiome and its contribution to preterm birth

description: This study will characterize the human maternal microbiome and host response profiles associated with term and preterm births and identify features of each that are predicitive of preterm labor and delivery
DOI: 10.21430/m3d8cs7ily
title: Characterization of the human maternal immune response 6 months or greater post delivery via cytometry Time-of-Flight(CyTOF).

description: This study will characterize the human maternal immune system and identify immune markers potentially associated with pre-term birth events.
DOI: 10.21430/m3d8e1d6z8
title: A Mouse Model of Chronic West Nile Virus

description: Using the Collaborative Cross, a population of recombinant inbred mouse strains with high levels of standing genetic variation, we have identified a mouse model of persistent WNV disease, with persistence of viral loads within the brain.
DOI: 10.21430/m3dlu018lb
title: MaHPIC: Host M. mulatta infected with P. cynomolgi

description: MaHPIC Experiment 04: Immunological measures of Macaca mulatta infected with Plasmodium cynomolgi B strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses
DOI: 10.21430/m3e3voedy2
title: Humoral responses to Influenza vaccination in aged populations - Year 3 2013 (See companion studies SDY272 2011, SDY622 2012, SDY739 2014, SDY819 2015)

description: The purpose of this study was to measure the B celland T cell responses to the Trivalent Inactivated influenza Vaccine(TIV) in young and aged subjects, and measure their different B cell subsets.
DOI: 10.21430/m3e3zntj56
title: Innate Immune Pathways in Elderly and Immunosuppressed Populations 2012

description: Innate Immune Pathways in Elderly and Immunosuppressed Populations
DOI: 10.21430/m3eel6ilmk
title: Mayo Clinic Smallpox Vaccine Immunogenetics Replication Study

description: Smallpox Vaccine Immunogenetics
DOI: 10.21430/m3enn2d3sz
title: Investigating Alterations to the Nasal Microbiome after Vaccination with LAIV

description: Microbiome alteration in response to influenza vaccine
DOI: 10.21430/m3esfsl9va
title: Key Role of T cell Defects in Age-Related Vulnerability to West Nile Virus

description: In a mouse model of age-related vulnerability to WNV, we demonstrate that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV. Specific age-related defects in T cell responses against dominant WNV epitopes were detected at the level of cytokine and lytic granule production, each of which are essential for resistance against WNV, and in the ability to generate multifunctional anti-WNV effector T cells, which are believed to be critical for robust antiviral immunity. In contrast, at the peak of the response, old and adult T cells exhibited superimposable peptide sensitivity. Most importantly, although the adult CD4 or CD8 T cells readily protected immunodeficient mice upon adoptive transfer, old T cells of either subset were unable to provide WNV-specific protection. Consistent with a profound qualitative and quantitative defect in T cell immunity, old brains contained at least 12x fewer total effector CD8 T cells compared with adult mice at the peak of brain infection. These findings identify potential targets for immunomodulation and treatment to combat lethal WNV infection in the elderly
DOI: 10.21430/m3ewwo0ere
title: Histology post influenza

description: Lung immunohistology post influenza infection
DOI: 10.21430/m3f0jeoksx
title: Dendritic cells and TH2 differentiation in vivo

description: TH2 cell differentiation was investigated by measuring IL-4 output after OVA plus papain challenge in normal and dendritic-cell depleted mice. The role of migrating dermal dendritic cells in OVA plus papain challenge by blocking migration and depleting dendritic cell subtypes.
DOI: 10.21430/m3f345zl81
title: Genetic Associations with Gestational Duration and Spontaneous Preterm Birth

description: This study identified four loci involved in gestational duration and three with preterm birth through a genome-wide association screen performed on a discovery data set and confirmed with a replication data set.
DOI: 10.21430/m3f6n2wgko
title: Effect of tissue-specific PPARg deficiency in bacterial loads

description: In this study WT, CD4 cre+ and LysMcre- mice were infected with H. pylori strain SS1 for six months.
DOI: 10.21430/m3f6zx0trg
title: T1DAL ITN045AI: Inducing Remission in New Onset Type 1 Diabetes Mellitus with Alefacept(Amevive)

description: The purpose of this trial is to test whether a drug called alefacept will slow or halt destruction of the beta cells in the pancreas. If the destruction of the beta cells is stopped, the patients might be able to produce insulin on their own longer, which could stop or slow the progression of their type 1 diabetes.
DOI: 10.21430/m3funsczck
title: Immune Responses to Seasonal Influenza Vaccination in Mouse model

description: Seasonal influenza vaccine study with Murine subject
DOI: 10.21430/m3fz2bazsa
title: Age-related alterations in innate immune responses (See companion study SDY736)

description: Aging leads to dysregulation of multiple components of the immune system that result in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented but the effect of aging on innate immunity remains incompletely understood. Using a heterogeneous population of peripheral blood mononuclear cells (PBMCs), we first undertook transcriptional profiling and found that PBMCs isolated from old individuals (&gt;= 65 yrs) exhibited a delayed and altered response to stimulation with TLR4, TLR7/8, and RIG-I agonists compared to cells obtained from adults (&lt;= 40 yrs). This delayed response to innate immune agonists resulted in the reduced production of pro-inflammatory and antiviral cytokines and chemokines including TNFa, IL-6, IL-1b, IFNg, IFNa, CCL2 and CCL7. While the major monocyte and dendritic cell subsets did not change numerically with aging, activation of specific cell types was altered. PBMCs from old subjects also had a lower frequency of CD40+ monocytes, impaired up-regulation of PD-L1 on monocytes and T cells and increased expression of PD-L2 and B7-H4 on B cells. The defective immune response to innate agonists adversely affected adaptive immunity as TLR-stimulated PBMCs (minus CD3 T cells) from old subjects elicited significantly lower levels of adult T cell proliferation than those from adult subjects in an allogeneic mixed lymphocyte reaction (MLR). Collectively, these age-associated changes in cytokine, chemokine and interferon production, as well as co-stimulatory protein expression could contribute to the blunted memory B and T cell immune responses to vaccines and infections.
DOI: 10.21430/m3g230oyom
title: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2009 (See companion studies SDY315 2012 / SDY314 2008 / SDY311 2010 / SDY112 2011)

description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
DOI: 10.21430/m3g6qjn9d5
title: Host responses to Enteroaggregative Escherichia coli (EAEC) infection

description: Enteroaggregative Escherichia coli (EAEC) is increasingly recognized as a major cause of diarrheal disease globally. In the current study, we investigated the impact of zinc deficiency on the host and pathogenesis of EAEC. Mouse model of enteroaggregative E. coli infection in mice that are fed one of four different diets: Control diet (20% protein) Control diet - Zn (20% protein, no zinc) RBD (7% protein) RBD/ZD (7% protein, no zinc)
DOI: 10.21430/m3g6vgudeh
title: Use of Rituximab for Sjogren's Syndrome (ASJ01)

description: Twelve adults will be enrolled in this study to evaluate the safety of using rituximab (Rituxan), a monoclonal antibody, for the treatment of Sjogren's syndrome. Participants will receive 2 intravenous doses of rituximab over a 2-week period and be monitored periodically for 1 year to evaluate for possible side effects and changes in the signs and symptoms and laboratory manifestations of disease. Studies are also planned to evaluate the mechanisms of the treatment effects, including changes in the properties of immune cells and the characteristics of the salivary gland tissue.
DOI: 10.21430/m3glg1r2ny
title: Molecular Profiling of Donor and Recipient Proinflammatory and Allograft Response (CTOT-03)

description: A prospective observational cohort study designed to test the association of proinflammatory pathways of injury in thoracic (lung and heart) and abdominal (kidney and liver) donor organs, with immediate and short term allograft function as well as subsequent alloimmune response.
DOI: 10.21430/m3gwqrc8dt
title: Immunologic and genomic signatures of influenza vaccine response - 2011 (see companion studies SDY63, SDY400, SDY520)

description: Project 1: Immunologic and genomic signatures of influenza vaccine response - year2 2011
DOI: 10.21430/m3hc3f4a8x
title: A targetable CD109-Janus kinase-Stat axis in metastatic lung cancer.

description: By coupling the systematic genomic analysis of purified cancer cells in distinct malignant states from mouse models with extensive human validation, we uncovered several key regulators of metastatic ability, including an actionable pro-metastatic CD109 Jak Stat3 axis.
DOI: 10.21430/m3hia408zr
title: IL-21 expression during H. pylori infection

description: The development of gastritis during Helicobacter pylori infection is dependent on an activated adaptive immune response orchestrated by T helper cells. The relative contributions of T helper 1 (Th1) and T helper 17 (Th17) subsets to gastritis and control of infection are still under investigation. Expression of IL-21, which may be produced by a number of T cell subsets, has been reported to increase during H. pylori infection. To investigate the role of IL-21 in the gastric mucosa during H. pylori infection, we combined mathematical modeling of CD4+ T cell differentiation with in vivo studies to elucidate the impact of IL-21 on H. pylori infection. Our computational modeling efforts predict that IL-21 activates the production of IFN gamma and IL17, the expression of Tbet and RORgamma t, the phosphorylation of STAT3, and suggest a potential role of IL-21 in the modulation of IL-10. To elucidate the role IL-21 in vivo, we infected IL-21 deficient mice and wild-type littermates with H. pylori strain SS1, and assessed colonization, gastric inflammation, cellular infiltration, and cytokine profiles in the gastric tissue.
DOI: 10.21430/m3huhjspbp
title: A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data

description: The authors applied high-throughput sequencing of blood-based B-cell DNA from healthy control and multiple sclerosis patients and used a computational method, the Haystack Heuristic, to query and analyze data for B-cell related disease biomarkers
DOI: 10.21430/m3hv9nrs67
title: Systems Biology Analysis of the response to Licensed Hepatitis B Vaccine (HEPLISAV) in specific cell subsets (see companion studies SDY299 and SDY690)

description: Out of 10 Donors, PBMC and 7 sort fractions were processed for 5 Donors(HEPLISAV-001,HEPLISAV-010,HEPLISAV-011,HEPLISAV-017,HEPLISAV-025) to assess for Microarray for all 9 time points. Further PBMC and 7 sort fractions were processed for 5 additional donors (HEPLISAV-002,HEPLISAV-005,HEPLISAV-019,HEPLISAV-024,HEPLISAV-026) to assess for Microarray for timepoint (days 0,1,7 and 35).
DOI: 10.21430/m3hzzos3y5
title: Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations (PROSE/ICAC-20)

description: A three-armed prospective randomized double-blind placebo-controlled trial investigating the efficacy of standard care plus 4-5 months of treatment with (a) a boost of inhaled corticosteroid therapy Flovent Diskus (fluticasone) versus (b) Xolair(omalizumab) or (c) placebo Xolair (omalizumab) and placebo Flovent Diskus (fluticasone) in reducing the exacerbations during the fall season.
DOI: 10.21430/m3i7tjb7l2
title: Temporal Response to seasonal and pandemic H1N1 infection in human DCs

description: Purpose: mRNA expression analysis of DC response to influenza viruses. Experiment variables (brief description of biological sample treatments and time points): human mDCs are infected with H1N1 influenza viruses (IAV) Brevig/1918, California/09, New Caledonia/99 and Texas/91 for 2, 2.4, 3.2, 4, 5, 6, 7 and 8 hours. RNA is isolated and hybridized to gene expression microarrays
DOI: 10.21430/m3i8w54c3m
title: 2013 Murine Vaccine with Adjuvant Study

description: Study of Influenza vaccine coupled with adjuvant in Murine model
DOI: 10.21430/m3jdeixf26
title: Project 3 - Optimization experiments DCs DV2 and DV4 - CyTOF

description: Ex vivo infections of DCs DENV2 and DENV4
DOI: 10.21430/m3jx1jsolb
title: An Interactive Reference Framework for Modeling a Dynamic Immune System

description: We leveraged mass cytometry, a platform that allows measurement of multiple parameters simultaneously at the single-cell level, to initiate a reference map of the immune system. By combining the throughput of flow cytometry with the resolution of mass spectrometry, this hybrid technology enables the simultaneous quantification of 40 parameters in single cells. Use of mass cytometry allows fluorophore reporters to be replaced with isotopically-pure, stable heavy metal ions conjugated to antibodies or affinity reagents. These reporter ions are then quantified by time-of-flight mass spectrometry to provide single-cell measurements, enabling a more detailed characterization of complex cellular systems for a robust reference map.
DOI: 10.21430/m3ktj8sa7a
title: Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis (YF08)

description: The purpose of this study is to determine the immune response to a yellow fever vaccine in adults with Atopic Dermatitis.
DOI: 10.21430/m3kvvhm735
title: Immunologic and genomic signatures of influenza vaccine response - 2013 (see companion studies SDY63, SDY404, SDY400)

description: Project 1: Immunologic and genomic signatures of influenza vaccine response - year4 2013
DOI: 10.21430/m3l410efmq
title: Systemic Immunity for Cancer Immunotherapy

description: A systems approach reveals that engagement of systemic immunity is critical to the process of tumor rejection following immunotherapy. Using a spontaneous model of triple-negative breast cancer, we assessed immune cell dynamics across the organism during tumor rejection
DOI: 10.21430/m3l7jsjolt
title: Assessing the role of NLRX1 during mucosal immune responses to H. pylori in mice

description: This study examines the role of NLRX1 in modulating immune responses to H. pylori infection.
DOI: 10.21430/m3lj1coixp
title: An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency

description: 1) High ARNTL2 is a top predictor of lung adenocarcinoma patient outcome,2) Arntl2 is required for metastatic ability in vivo and clonal growth in cell culture,3) An Arntl2-driven pro-metastatic secretome controls metastatic self-sufficiency,4) Smoc2 is an Arntl2/Clock-dependent pro-metastatic secreted factor
DOI: 10.21430/m3lo7mv28o
title: Mouse Study of X31 Influenza Infection

description: Influenza primary infection study with murine subject
DOI: 10.21430/m3lu5ysbyo
title: Anti-TNF Agents in RA (ARA06)

description: The primary purpose of this study is to determine the effectiveness of two TNF inhibitors, etanercept and adalimumab, on memory B lymphocytes (B-cells) in the peripheral blood of participants with RA.
DOI: 10.21430/m3lvufrqoa
title: Biomarkers of Cockroach Sublingual Immunotherapy 2 (BioCSI 2/ICAC-17)

description: This study looks to compare two doses of glycerinated German cockroach allergenic extract versus placebo administered via the sublingual route in 99 children ages 5 to 17 years with perennial allergic rhinitis, asthma, or both. It is designed to study biomarkers of the immune response to allergen immunotherapy as well as the safety of this therapy.
DOI: 10.21430/m3lvyi9uli
title: Mouse recombination path counting on a gpu

description: Goal is to test convergent recombinaiton as a predicor of TCRb production efficiency.
DOI: 10.21430/m3m6badc48
title: Monozygotic and Dizygotic Twin Pair T-Cell Responses to Influenza Vaccination 2009

description: Evaluate the variation in immune response between individuals and assess whether it changes as a function of age and similarity in genetic and environmental background (by comparing differences between monozygotic and dizygotic twin pairs of different ages).
DOI: 10.21430/m3m92y22fg
title: Anti-CD20 in SLE (AC002)

description: The purpose of this study is to determine the safety and effectiveness of rituximab (anti-CD20) in treating systemic lupus erythematosus (SLE). White blood cells in the body called B cells give off substances that are active in promoting SLE disease. Researchers have found that anti-CD20 can block production of these substances in another disease. This study explores whether anti-CD20 will also be safe in people with SLE and whether it may be effective in treating SLE.
DOI: 10.21430/m3miplu7zu
title: CMV CD8 T Cells

description: An analysis of human cytomegalovirus (CMV)-specific T cell responses and CMV persistence in multiple anatomic sites including blood, lymphoid, mucosal and secretory tissues of CMV-seropositive donors.
DOI: 10.21430/m3n3rfl2e5
title: Phosphorylation profiles of ERK, p38, MAPKs in DCs in response to different pathogenic stimuli

description: 2 different stimuli were used to activated DCs LPS and Curdlan. A time course experiment was conducted for 2 hr to measure the phosphorylation profiles of MAPKs, ERK1/2 and p38.